Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cryo analytical microscopy of cell-mediated mineralization in models of bone disease (BoneImaging)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

The bone mineralization process is crucial in maintaining the mechanical integrity of bone, from the time of its development to its constant remodeling throughout life. The process of pathologic mineralization and bone remodeling and how cells control these processes, is very poorly understood in vivo. By characterizing unique animal models of bone pathologies, spanning both lack and increase of bone, this project will elucidate the process of cell-regulated mineralization during endochondral ossification, the mineralization process that occurs during growth of long bones, and also during adult remodeling. We will also investigate how a defect in mineralization affects the mineral content, composition and organization of the collagen fibrils and mineral in pathological bones. We will first map healthy (wildtype) mineralization, focusing on the cell regulated mineralization, mineral composition and structure in bone and calcified cartilage. We will then investigate how the cell regulated mineralization alters in hypomineralized bone models, which have been reported as abnormalities of skeletal development. Finally, we will study the bone remodeling in under and over producing bones in leukemia and parathyroid hormone (PTH) treated animal models. To address these problems, this work will combine multiscale, state of the art imaging and analysis techniques from dynamic live animal imaging (cellular level) to spatially resolved nanoscale (mineral and collagen fibrils) analytical techniques to characterize the processes by which bone mineralizes, remodels and also any alterations in these processes between healthy and pathologic tissues. Insight into skeletal cellular mineralization mechanisms in pathologic tissues could guide tissue engineering approaches for restoring bone and help to identify targeted treatments.

Keywords: bone mineralization,bone pathology,analytical electron microscopy,intravital microscopy,cryo,electron microscopy
Conversational Human-Aware Technology for Optimisation (CHAT-Opt)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1893125.0
EU funding (EUR): 1893125.0
Participants: 1
Project status: SIGNED

Industry and society are increasingly automating processes, which requires solving constrained optimisation problems. This includes vehicle routing problems in transportation, scheduling of tasks in electricity demand-response programs, rostering of personnel and more. However, the solutions found by state-of-the-art constraint programming solvers are often found to not match user expectations. Solutions are regularly critiqued by domain experts as impractical, frustrating for people involved or creating unfair situations that a human planner would never propose. As a result, the technology is not accepted or workarounds like manual processing is done which reduces its potential. This project is based on the idea that we must shift away from the concept of the optimal solution, and must move to that of the desired solution. To make the solutions more humane, we must make the solution process more human-aware. The key to this is to integrate techniques from machine learning that can learn about the context of the environment and user. This can move the problem formulation process from a one-shot model + solve paradigm to a dialogue-based conversation paradigm between the end-user and the solver. The focus here is not on the use of natural language, but rather on making the constrained programming technology ready for such interactions. This project aims to fundamentally advance it on three fronts: 1) to learn from the environment and integrate the learning and the predictive models into the optimisation; 2) to learn the implicit preferences form the user by letting her/him interact with the solutions; and ultimately 3) to develop a conversational constraint solver that can answer unambiguous questions of the users in terms of explanations and alternatives. The end goal is a system that lets the user co-create a solution that she/he desires, and that system can adapt to changing needs and preferences over time.

Keywords: combinatorial optimisation,machine learning,constraint solving
TRA VISIONS 2022 (TRA VISIONS 2022)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Germany,Italy,Belgium,Greece,Sweden,Belgium,Netherlands,Portugal,United Kingdom,Portugal
Call: Improving impact and broadening stakeholder engagement in support of transport research and innovation (H2020-MG-2020-SingleStage-INEA, 2020)
Start date: 2020-11-01
End date: 2023-03-31
Duration (months): 29.0
Total project cost (EUR): 700000.0
EU funding (EUR): 700000.0
Participants: 12
Project status: SIGNED

The scope of this proposal, as requested by the call, is to organise two competitions for transport research awards to be announced at the TRA conference in 2022: - a young researcher competition with the goal of stimulating the interest in the field of sustainable transport among young researchers and students. - a competition for senior researchers in the field of innovative transport concepts based on results only from EU-funded projects.

Keywords: education and public outreach
New Mining Concept for Extracting Metals from Deep Ore Deposits using Biotechnology (BioMOre)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Spain,Germany,South Africa,Austria,Germany,Finland,Poland,Poland,Finland,Poland,Sweden,Poland,France,France,France,United Kingdom,United Kingdom,United Kingdom
Call: Mining of small and complex deposits and alternative mining (H2020-SC5-2014-one-stage, 2014)
Start date: 2015-02-01
End date: 2018-07-31
Duration (months): 42.0
Total project cost (EUR): 8564961.75
EU funding (EUR): 8564961.75
Participants: 27
Project status: CLOSED

BioMOre describes a “New Mining Concept for Extracting Metals from Deep Ore Deposits using Biotechnology”. The concept is to use hydrofracturing for stimulation and bioleaching for winning of ores. The final process will consist of a so-called doublet, which is two deviated and parallel wells. In order to avoid high costs for drilling from the surface, the BioMOre approach is divided into two phases. Phase 1 will be research on the intended bioleaching process whereas phase 2 will aim at a pilot installation to demonstrate the applicability of the process in large scale including hydro-fracturing and access of the deposit from surface. The first phase should cover the intended work of the current BioMOre approach without drilling from surface. The BioMOre project aims at extracting metals from deep mineralized zones in Europe (Poland-Germany, Kupferschiefer deposit as a test case) by coupling solution mining and bioleaching. Selected sustainability indicators based on regulatory requirements of the European Commission will be applied for feasibility considerations. The main objective of the BioMOre first phase is to design and build an underground test facility for testing the concept of combined hydro-fracturing and bioleaching. The test facility will comprise a 100 m² ore block, where boreholes will be drilled horizontally using standard equipment. All necessary equipment for testing different parameters of the intended bioleaching process will be established underground. The intention is to test the bioleaching process in high detail in an in-situ environment at the same time avoiding time consuming and risky permission procedures. On the other hand, the application for the permission of underground test operation must contain detailed information about monitoring of tests and all material controls. No harmful substances will remain in the mine after the tests are completed. Further to that, predictive numerical modelling of a pilot installation should be done.

Keywords: biotechnology,hydrofracturing,bioleaching,in situ mining,solution mining,in situ leaching
Perioperative infection prediction (PERISCOPE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Some 50M people need to undergo inpatient surgery per year in Europe Yet, despite intensive research efforts, around 25% of surgical patients will experience a complicated recovery with some type of infection on their path: pneumonia, urinary tract infections, wound infections, abdominal infections and bacteremia. Of course, the risk varies depending on the patient and the procedure, but despite efforts like biomarkers, risk scores or devices for early warning/detection, and preventive methods like ‘Enhanced Recovery After Surgery’ (ERAS), the overall risk still leaves almost one in four patients to get an infection within 30-days after surgery. If we look beyond the personal suffering of patients and relatives, the cost of an infectious complication is estimated at around €10,000 per patient. Hence, total cost in only the Netherlands alone can be calculated at up to €3.5B per year, as approximately 350,000 Dutch patients go through an infection after surgery yearly. Total EU costs are even more shocking at an estimated €125B per year. Healthplus.ai R&D BV is currently developing an advanced machine-learning (ML) algorithm (TRL level 4) to predict post-operative infections 5 days prior to the average medical team diagnosis, currently already achieving an accuracy of 80%. Through increasing the dataset and taking on more types of data, the ultimate goal is to ultimately achieve >90% accuracy at 5 days before the infectious symptoms on average are actually detected within the patient. In this proposal, we seek how to go beyond the proven technical feasibility and assess channels to deliver the tool in a safe, affordable and scalable way through third-party vendors with a sustainable business model and plan with the right partnerships and intensify these relationships. Also, potential legal and regulatory issues with EU expansion will be identified, investigated and suitable measures outlined.

Keywords: perioperative process,medical,surgery recovery,infections,health prediction,machine learning,deep learning,diagnostics,advanced algorithms,wearables,electronic health systems,hospitals
Evaluation of Novel Ultra-Fast selective III-V Epitaxy (ENUF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Switzerland,France
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 75000.0
Participants: 3
Project status: CLOSED

As the worldwide photonics market is increasing and optical and electronic devices based on III-V semiconductors are gaining market segment, the production of III-V semiconductor wafers including GaN has increased in volume and sizes have increased from 2” to 6”. However, this is still short of the 8”-12” common in Silicon CMOS technology. Furthermore, the integration of III-Vs on silicon or on-insulator, has been a long-standing goal for the past 50 years, in order to combine electronic and photonic applications, and to allow photonic technologies to take advantage of the highly developed silicon CMOS technology, thereby opening up for vast new application opportunities. The aim of ENUF is for the first time to attempt to combine two different growth methods to achieve a low-cost integration of large-area III-V on insulator on a silicon platform, and to establish this as a replacement technology for existing III-V wafer production or to enable low-cost integration of optically active material as enabling technology for silicon photonic applications. The method can also be adapted to GaN on Si or on insulator for low-cost high-volume production of high power electronics and light emitting devices.

Keywords: compound semiconductors,epitaxy,semiconductor wafer technology
Rare Earth Free e-Drives featuring low cost manufacturing (ReFreeDrive)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Italy,Italy,Italy,Italy,Germany,Italy,Spain,Belgium,France,United Kingdom,United Kingdom,United Kingdom
Call: Next generation electric drivetrains for fully electric vehicles, focusing on high efficiency and low cost (H2020-GV-2017, 2017)
Start date: 2017-10-01
End date: 2021-03-31
Duration (months): 42.0
Total project cost (EUR): 5999131.25
EU funding (EUR): 5999131.25
Participants: 13
Project status: CLOSED

The ReFreeDrive project is focused on contributing to avoid the use of rare earth magnets through the development of a next generation of electric drivetrains, ensuring the industrial feasibility for mass production while focusing on the low cost of the manufacturing technologies. This proposal intends to study and develop simultaneously two solutions for the power traction system of electrical vehicles. Both solutions are brushless AC electrical machines: induction machine with fabricated and copper die-cast rotor (IM) and synchronous reluctance (SynRel) machine. Through their configurations these machines not only are rare-earth magnet free, but also share common features that can be exploited during the design step, as well in the manufacturing process. These common features lead to a complex synergy between the two technologies, which justify the development of different topologies of electric machines in just one project. The design of the ReFreeDrive motors will take as a premise the reduction of use of materials, as more than half of the final price is formed by raw materials cost. Also, a minimization of manufacturing costs will be ensured by an early involvement of manufacturers, from the design stage. ReFreeDrive motor topologies have good room for cost reduction by off-setting permanent magnet use. However, it is not feasible to change the commodity prices for copper and steel. Therefore, one of the key avenues for cost reduction is the reduction of size through different techniques (outer rotor, higher rotational speed, compact winding…). An optimized use of copper on the project provides technical design with a higher efficiency due to lower losses regards other alternatives, and more efficient heat management. Beyond the motor design, ReFreeDrive also consider an integrated design of the power train that allows the optimization of the electric connections, the cooling systems and the housing.

Keywords: cost reduction,rare earth free,enhanced power electronic,innovative cooling system,induction motors,synchronous reluctance machines
Regulation of Single Hematopoietic Stem Cells by Intake of Vitamin A (VitASTEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-05-01
End date: 2024-04-30
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Quiescence preserves the self-renewal capacity and the long-term function of hematopoietic stem cells (HSCs). The regulators of this dormant state include intrinsic pathways and soluble components in the bone marrow niche. Dysregulation of this process is poorly defined and might cause aberrant hematopoiesis. In my previous work, we defined the molecular landscape of HSCs by applying state of the art DNA-methylome, RNA-seq and proteome analyses, and found vitamin A/retinoic acid (RA)-induced signaling predominantly enriched in HSCs (Cabezas-Wallscheid et al., Cell Stem Cell 2014). Intriguingly, we observed that mice fed with a vitamin A-free diet exhibited a robust loss of HSCs (Cabezas-Wallscheid et al., Cell 2017). Treatment of mice with a RA agonist preserved HSC quiescence in stress-activated conditions, indicating that the balance between HSC maintenance and differentiation is tightly regulated by vitamin A signaling. However, we are only beginning to understand the mechanisms how vitamin A regulates HSC fate. Since treatment of vitamin A deficiency currently shows extremely low therapeutic success, novel insights into the role of HSCs in the development of the disease will be of enormous therapeutic value.

Keywords: hematopoietic stem cells,vitamin a,single cell,omics
ENHANCEMENT 2015-16 SERVICES TO ENHANCE THE INNOVATION MANAGEMENT CAPACITY OF GREEK SMEs (ENHANCEMENT 2015-16)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Greece,Greece,Greece,Greece,Greece,Greece,Greece,Greece
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 281208.2
EU funding (EUR): 281208.2
Participants: 12
Project status: CLOSED

The project aims to support the innovation management capacity of Greek SMEs as a mean for advancing competitiveness and ensuring growth. Four partners of the Enterprise Europe Network-Hellas will provide mentoring and coaching services on all stages of the innovation management system, including the innovation process from idea generation to innovation results, leadership, management skills and other enabling factors, such as collaboration with R&D partners, clients and suppliers. The service is of particular significance for Greek SMEs that have been seriously affected by the lasting financial recession and need support activities directly aiming at boosting their competitiveness and growth. The proposal addresses the specific objectives of the work programme, namely: a) Identification of bottlenecks in the innovation management process of SMEs benefitting from grants by Horizon 2020’s SME instrument and address these bottlenecks with the help of capable coaches, b) Increase the efficiency and effectiveness of innovation processes in SMEs with significant innovation activities that could potentially become beneficiaries of European support to research and innovation. The service will be delivered by nominated experts of the Enterprise Europe Network-Hellas consortium. 176 service packages (7-days each) are foreseen to be delivered by the end of December 2016, to: a) Beneficiaries of the SME Instrument, b) SMEs with significant be selected based on a multi-parametric process, incorporating both geographical and sectorial criteria. National priorities for research and innovation in Greece and priorities of the Smart Specialization Strategy of each region will be taken into consideration. Common high level quality standards and predefined procedures will be developed for all partners to maximize the efficiency of the service.

Keywords: innovation capacity,key account management,enhancing enterprise europe network,innovation management
modUlaR and flexible solutions for urBAN-sIzed Zero-Emissions last-mile Delivery and services vehicles (URBANIZED)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Germany,Spain,Italy,Spain,Belgium,Romania,Greece,Netherlands
Call: Next generation electrified vehicles for urban and suburban use (H2020-LC-GV-2020, 2020)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 6398681.08
EU funding (EUR): 5119239.6
Participants: 11
Project status: SIGNED

The steadily growing demand related to increasing urbanisation is turning the management of logistics flows in urban areas a more complex process, with higher demand for adaptability and flexibility for the new solutions to contribute to optimise the overall transport capacity, reducing operational costs and negative impacts (health, safety). URBANIZED develops and demonstrates the next generation of modular vehicle architectures for urban-sized commercial e-vehicles, satisfying design principles of optimisation and right-sizing vehicles for their mission, delivering outputs in 3 dimensions: 1) high-performance e-powertrain components and control architectures, through the use of advanced co-design approaches; 2) interchangeable, plug & play cargo modules for different urban freight transport use case scenarios and 3) integrated energy and fleet management strategies using data, connectivity and learning algorithms. URBANIZED follows a holistic design approach working at 3 levels (systems, vehicle, fleet) during the entire project: starting with the definition of specific mission profiles within 2 main pre-selected use cases (last-mile delivery of retail, e-commerce, courier and post; HoReCa and other urban on-demand services), during the optimisation loops of the design process, and until project demonstrations, to be performed both physical and in virtual environments, covering the specific requirements of operators. URBANIZED brings a complementary multi-disciplinary consortium of 9 partners from 6 EU countries, involving all relevant actors from the value chain, from academic, to industrial (TIER1, OEMs) and logistics operators. Aiming at broadening dissemination and impact, URBANIZED defines an extended partnership, involving 3 satellite cities (Groningen, Madrid and Bergen) committed to CO2-emissions free logistics in their city centres by 2030 and a high volume OEM (Ford) highly positioned in the LCV market, all interested in replicability of project results.

Keywords: modular and flexible ev platform,predictive ev energy and fleet management strategies,euro ncap safety rating for heavy quadricycles,sustainable urban freight transport,last mile delivery vehicles