Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Partnership for New Energy Leadership 2050 (PANEL 2050)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Estonia,Austria,Bulgaria,Hungary,Romania,Slovenia,Poland,Lithuania,North Macedonia,Latvia,Czechia
Call: Empowering stakeholders to assist public authorities in the definition and implementation of sustainable energy policies and measures (H2020-EE-2015-3-MarketUptake, 2015)
Start date: 2016-03-01
End date: 2019-02-28
Duration (months): 36.0
Total project cost (EUR): 1790500.0
EU funding (EUR): 1790500.0
Participants: 13
Project status: CLOSED

The aim of PANEL 2050 project is to create durable and replicable sustainable energy networks at local (municipality/community) level, where relevant local stakeholders collaborate for the creation of a local energy visions, strategies and action plans for the transition towards low carbon communities in 2050. The PANEL 2050 project will focus on the creation of these sustainable local energy networks in CEE countries, where this type of networks at local level is almost completely absent and therefore additional support is needed for the creation of the first successful local energy networks that have the potential to set an example and a new standard for local energy road mapping in other local communities in the CEE region. Furthermore, the PANEL 2050 project will not choose a specific focus on a certain type of stakeholder, but will try to work at the local level and assemble all relevant and available stakeholders related to sustainable energy. The number and type of stakeholders will vary very much in different local settings and the ambition of this project is to create sustainable energy networks at local level that will connect and involve all relevant stakeholders that are present at local level into the local policy development and implementation. At present, the involvement of local shareholders in local policy development in any field in CEE countries is very limited and the aim of this project is to create durable sustainable energy networks in a number of local communities in different CEE countries that will also be a replicable example that can be spread to other communities in CEE countries. Introducing stakeholder concept to energy planning will help generate sustainable energy policies and create more sustainable future for Europe.

Keywords: stakeholder involvement,public engagement,sustainable energy,energy roadmap 2050
Scalable Software Defined Network Architectures for Cooperative Live Media Production exploiting Virtualised Production Resources and 5G Wireless Acquisition (VIRTUOSA)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Israel,Germany,Germany,Poland,Norway,United Kingdom
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2019)
Start date: 2019-09-01
End date: 2022-02-28
Duration (months): 30.0
Total project cost (EUR): 2788930.42
EU funding (EUR): 1995500.0
Participants: 6
Project status: CLOSED

VIRTUOSA addresses the needs of the Media & Entertainment (M&E) industry to increase efficiency and reduce cost for media production to meet the growing consumer demand for more content on more channels and more devices and for more live content. Live content is of cultural and social interest for all citizen in Europe and globally; these are sport or music events, daily news, governmental speeches or historical events. The market for Live content is huge and predicted to reach globally USD 545 bn with the clear majority (66%) coming from broadcast Live TV. VIRTUOSA will revolutionise live media production through Virtualisation of network and production resources. It is a new generation of media networks based on cutting-edge IP technology, Software-Defined Networking (SDN) technology, High Performance Computing, and Cloud Computing. Virtualisation is the key to make live media production more efficient, easy scalable and cost-efficient. It enables sharing production facilities, equipment, resources, and talents across locations with >1000 km in distance . Live media production costs will be reduced by 30-40%, and more Live content can be easily produced in parallel. Objective of the VIRTUOSA project is to demonstrate and validate our new VIRTUOSA product in operational environment and to complete commercial and production preparations for product launch within this 24-month project. Our VIRTUOSA product consists of three core elements: 1) A tailor-made Software Defined Network Architecture solution for SDN-based LAN & WAN and 5G acquisition, 2) High performance SDN-based Media Server and Ethernet/IP switches, and 3) a Software for Media Network Management and self-Service Orchestration. According to the need of our end-users – broadcasters, content producers, media service providers – we design tailor-made solutions for installation at their facilities with and without the connection to remote locations (remote studio, stadium, event).

Keywords: future media production infrastructure,sdn software defined networks,nfv network functions virtualization,hpc based media server,media network and resource orchestration software
Targeting stromal cells to modify tumor mechanical microenvironment and optimize drug delivery (STROMAMECH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Cyprus
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 151648.8
EU funding (EUR): 151648.8
Participants: 1
Project status: CLOSED

Current chemotherapeutic agents are potent enough to kill cancer cells. Nonetheless, failure of standard chemotherapies for many cancer types (e.g., pancreatic and breast cancers) is primarily attributed to these agents never reaching cancer cells in amounts sufficient for complete cure. In solid tumours, blood vessels are often compressed, drastically reducing perfusion, thus resulting in insufficient drug delivery. Vessel compression is a consequence of mechanical stresses accumulated within the tumour during progression. Alleviation of these stresses has the potential to reopen compressed vessels and improve tumour perfusion. Here, the applicant proposes to test the hypothesis that judicious depletion of stromal cells, namely the cancer-associated fibroblasts (CAFs), has the potential to alleviate stress levels in highly desmoplastic and hypoperfused tumours and, thus, enhance chemotherapy. To explore this hypothesis, a combination of cutting-edge computational and experimental techniques will be employed. Specifically, a structure-based biomechanical model will be developed to analyse the contribution of CAFs to the generation and transmission of forces within a tumour. Subsequently, in vivo studies will be performed in mice to validate model predictions and identify the degree of CAF depletion that optimizes the efficacy of treatment. Successful completion of the proposed research will reveal the role of CAFs on the biomechanical behaviour of tumours and contribute to developing a therapeutic strategy for treatment of hypovascular tumours. Therefore, the proposal negotiates a subject of considerable importance for European society and beyond. Furthermore, the proposed research and training will establish a bidirectional transfer of skills where the applicant’s expertise in cell mechanics will be complemented by the Host’s in cancer biophysics, thus enhancing the applicant’s scientific potential and professional maturity, and promoting European research.

Keywords: biomechanics,cancer treatment,drug delivery,mathematical modeling,animal studies
Devices, engines and circuits: quantum engineering with cold atoms (DECCA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2022-07-31
Duration (months): 66.0
Total project cost (EUR): 1454258.0
EU funding (EUR): 1454258.0
Participants: 1
Project status: CLOSED

Over the last decade, cold atomic gases have become one of the best controlled quantum system. This novel, synthetic material can be shaped at the microscopic level to mimic a wide range of models, and simulate the universal physics that these models describe. This project pioneers a new approach to quantum simulations, jumping from cold atoms materials into the realm of devices: systems carved out of cold gases, separated by interfaces, connected to each other and allowing for a controlled driving. At the heart of this approach is the study of transport of atoms at the quantum level. Our devices will allow for the measurement of the universal conductance of quantum critical systems or other many-body states. They will feature interfaces and contacts where new types of localized states emerge, such as the one proposed to explain the long-standing question of the “0.7 anomaly” in quantum point contacts. They will also allow for a new type of engineering, where currents of particles, spin or entropy can be controlled and directed in order to perform operations such as cooling. This research will be possible thanks to the development of a new apparatus, capable of detecting in a non-destructive way tiny atomic currents, such as the one driven through single mode quantum conductors. It will combine an optical cavity for high efficiency optical detection, and high optical resolution optics allowing for manipulations and patterning at the scale of the wave function of individual particles.

Keywords: strongly interacting fermions,quantum transport
Single-molecule visualisation of eukaryotic DNA replication termination to uncover novel mechanisms of replication stress (SinMolTermination)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-11
End date: 2021-04-15
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Replication-stress is a key driving force of cancer development, neurodegeneration and ageing. Many sources of replication stress associated with the initiation and elongation phases of DNA replication have been discovered. In contrast, little is known about the mechanisms of replication termination and termination-associated replication stress. Recent breakthroughs identified the first elements of a mechanism of replication termination that involved ubiquitination of the Mcm7 subunit of the CMG helicase. However, we do not know how terminating replisomes signal themselves for ubiquitination, nor how this is regulated both temporally and spatially along chromatin. By combining sophisticated single-molecule imaging techniques with the ability of Xenopus extracts to replicate DNA in a physiological manner, we will for the first time, be able to watch individual replication forks terminate. Importantly, our multidisciplinary and single-molecule approach will allow us to bypass the constraints posed by ensemble techniques that have hindered progress in this field. Specifically, we will define the spatial and temporal conditions upon which Mcm7 becomes ubiquitinated and how this is connected to the fate of the CMG helicase during termination. These observations will enable us to determine a complete mechanistic understanding of vertebrate replication termination for the first time. We will also discover how failed DNA replication termination triggers replication stress. Revealing these novel mechanisms of replication stress allows for new therapeutic targets to be identified and potentially facilitates new disease prevention strategies to be recognised.

Keywords: single molecule,dna replication,xenopus,tirf microscopy,fluorescence,verterbrate,biochemistry,molecular biology
One box to measure all the most important air pollutants and greenhouse gases (Lazaero)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Lazaero will radically disrupt the €4.2 billion air quality monitoring market as we know it with the very first all-in-one solution to measure the most important air pollutants (CO, O3, SO2, NO, NO2, NH3) and 4 greenhouse gases (H2O, CO2, CH4 and N2O) continuously, simultaneously and precisely. This is a huge jump from current technologies which monitor each gas separately via a mess of expensive, fixed instruments, each of which must be carefully calibrated by expert technical staff and can suffer from cross-sensitivities with other gases. Our technology applies the latest in direct laser absorption spectroscopy, with three novel dual-colour quantum cascade lasers (CQL), custom design electronics and software to create a plug & play, mobile, compact (20kg, 2.025 cm3) easy to use device that saves space and reduce costs. Lazaero doesn’t need a server or to be calibrated, so it can be operated without special training for 75% less operational and 40% lower startup costs compared to existing devices. Furthermore, Lazaero will widely expand its potential use by moving it to different locations to get a more targeted measurement of air pollution. A more precise measurement of air contamination will help industry, authorities and research institutions implement strategies to improve air quality and avoid multi-million-euro fines from the EC, 71,000 deaths, €52 billion in medical costs in the EU. With our immediate launch into air quality monitoring network for polluting industries and universities in Europe and then expanding into public monitoring networks and into U.S. and Asia at later stage will make Miro a leader in air monitoring field. Investment by the EC will help us to decrease our prices as we scale up production to reduce our average unit price from €94.000 to just €50.000 by 2023 and reach break-even during year two on the market (2023). We estimate that the ROI after three years will be 4.46 with an accumulative profit of €7.59M.

Keywords: gas analysis,quantum cascade,pollution,measurement
Selective Electrochemical Reduction of CO2 to High Value Chemicals (SELECTCO2)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Switzerland,France,Netherlands,United States,United Kingdom,Denmark
Call: Developing the next generation of renewable energy technologies (H2020-LC-SC3-2019-RES-TwoStages, 2019)
Start date: 2020-01-01
End date: 2023-03-31
Duration (months): 39.0
Total project cost (EUR): 3971832.5
EU funding (EUR): 3772265.0
Participants: 9
Project status: SIGNED

This proposal will develop enhanced electrolysis devices enabling CO2 to be converted into high value chemicals. Specifically this project will improve selectivity, efficiency and durability of electrochemical CO2 conversion into either carbon monoxide, ethanol or ethylene. The immediate focus will be on the highly economically attractive chemicals industry, with the long term goal of using this as a stepping stone towards the fuels industry. New catalysts, gas diffusion layers, and membranes will all be developed to improve performance in commercially scalable type devices. Single site catalyst will be used to create high selectivity towards carbon monoxide production, whereas a dual catalyst approach will be used to produce ethanol. Variations in morphology and surface structuring will be the key to eliminating side reaction in ethylene production The greatest novelty of this project will be to use modifications in the reaction environment to effect reaction selectivity. The hydrophobicity and pore size will be varied in the gas diffusion layer and anion exchange membranes and ionomers will be developed to improve performance. The entire device will be comprehensively modeled from the quantum regime all the way to the complete device to relate macroscopic changes with catalytic improvements. Developments in both improved catalysts as well as optimization of reaction environment will allow for high CO2 conversion selectivity, (CO 90%, ethanol 80%, ethylene 90%) at high energy efficiencies (> 40%) and at high rates (> 200 mA/cm2). A life cycle analysis will focus on electrical power and CO2 inputs as well as the specific products to discover the most effective market opportunities for this technology moving forward. In addition social acceptance issues will be investigated to ensure this technology is developed in a manner that optimizes this aspect as well.

Keywords: electrochemistry,co2 reduction,chemicals,ethylene,ethanol,carbon monoxide,electrolyzer,catalysis
Knitting early modern Europe: materials, manufacture and meaning (KEME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

The development of knitting was a key technological innovation for which there is little published scientific evidence. There are more than 100 knitted caps from the early modern era in museum collections worldwide - an astonishing number given the paucity of extant garments from the period. Despite their diverse locations, they have remarkable similarities in their materials and manufacture which illustrate trade in knitted caps as consumer goods in the emerging early modern European marketplace, demonstrate how knitting created new fashions for men indicative of rank and status, and facilitate theory on the cultural significance of the hat as an essential male accessory. My preliminary study of the caps tracks clear patterns in the data: five typologies are identifiable and when contextualised with pictorial and documentary sources, their cultural significance as functional and fashionable men’s wear is clear. I believe the caps’ potential as indicators of the development and growth of knitting technology is valuable yet vulnerable. The caps are fragile and deteriorating, a process accelerated by each viewing, for which there is pressing and unsatisfied demand. I propose immediate rigorous scientific study (radiocarbon dating, microscopic examination, x-radiography, fibre and dye identification, and degradation analysis) and interdisciplinary research into contemporary sources to chart an economic map of early knitting, to define terminology for further scholarly work, and to develop theory about men’s headwear in the 16th century. An online database will make the data accessible to scholars, museum pedagogues and craftspeople, who demand access to the caps. Journal articles, practical workshops and social media will disseminate my conclusions and my development of theory. I will give voice to an eloquent body of evidence about early modern knitting technology, which threatens to be silenced forever if scientific analysis is delayed.

Keywords: archaeology,pedagogy
Open Philology: The Composition of Buddhist Scriptures (OpenPhilology)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 2498296.0
EU funding (EUR): 2498296.0
Participants: 1
Project status: CLOSED

Buddhist sūtras are fundamental sources for understanding the beliefs that once dominated, and largely continue to dominate, Asian societies. But classical philological approaches to these texts, assuming an Ur-text and linear development, misrepresent their nature and obscure their history. Like oral literature the sūtras are authorless and textually fluid, their content formulaic and modular, and the situation complicated by their huge volume and the linguistic diversity of their extant versions. Their fluidity and the absence of an Ur-text makes traditional stemmatic editing inappropriate. Other options are also unacceptable: eclectic editions conflate distinct sources, creating texts which never existed historically, while exclusive focus on a single version ignores the tradition’s true richness. Utilizing the tools of Digital Humanities, Open Philology offers a revolution in approaching the composition of these scriptures, and other literatures with common features, such as the Homeric corpus or Rabbinic literature. Given the vastness of the Buddhist canons, we will focus on a traditional subset of texts, and produce electronic editions which preserve their diachronic and synchronic fluidity, revealing the intertextuality inherent in their formulaic composition. Our editing environments will allow one to easily view the diversity of sources, in different versions of ‘the same text’ and in parallels in other texts, and permit one to view data at any level of granularity, according to one’s interests. The project will produce corpora of sūtras mutually aligned in their Chinese, Tibetan and, when available, Sanskrit versions, a map of formulaic content, annotated text editions and translations, a general study of the corpus, and a series of scholarly publications on methodological and content-oriented issues. The tools and results we produce will bring our historical understanding of Buddhism, the most formative influence on Asian cultures, to a new level.

Keywords: buddhism,scriptures,text critique