Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Assembly-based discovery of uncharacterized human microbiome members and their tracking across individuals and time (DiMeTrack)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-12-01
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

In this proposal we aim to expose and characterize members of the human-associated microbial dark matter and exploit the novel information to dramatically enhance the resolution of metagenomic profiling and develop accurate predictive/diagnostic tools. As a first step we will discover currently uncharacterized human microbiome members from metagenomic data through novel application of assembly-based approaches on a large compendium of newly generated and available shotgun metagenomes (Aim 1). The new identified genomes will be phylogenetically and taxonomically characterized and investigated to track strain-level individual and temporal genetic variability (Aim 2). The new genomes will be then used to develop a next generation host condition prediction approach through a genome-level machine learning tool (Aim 3). The three main objectives of the proposal are functional to the characterization of microbial dark matter from human microbiome and its use for strain-level microbiology tasks and metagenomic prediction/association tools. DiMeTrack focuses specifically on shotgun metagenomics and tracking across time and individual on many samples from publicly available databases and generated at the host laboratory. By discovering previously uncharacterized microorganisms and unravelling their roles in specific biological phenomena (e.g., mother-to-neonate transmission) and association with disease states, we fulfil the Horizon 2020 policies in supporting research and innovation that improve our understanding of the causes and mechanisms underlying healthy and diseased people and improve our ability to monitor and detect diseases. The profile and the future research plan of the applicant fits well with these research areas. In addition, after working in United States for a few years, he wants to be reintegrated in a research position in EU.

Keywords: assembly,human microbiome,machine learning,microbial dark matter,shotgun metagenomics
Multidevice software platform for caring elderly patients at home (KWIDO_TELECARE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-03-01
End date: 2017-07-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Eldercare services at home have been pointed as a promising field with great potential to generate new business opportunities for the ICT industry. European health and telecare services already cover basic needs and are really well-ranked but, will Europe be ready for the demographic explosion of these needs at patients’ home? How will ICT technology help Europe to keep the health and telecare systems sustainable?. The final goal is that elderly people or patients can be cared at home preventing all emergency situations that end in hospital admissions and making telecare services sustainable for an increasing number of end users. Unfortunately, up to now the achievement of these objectives have been hampered by the limited functionalities of the ICT solutions and the high price of advances technical devices used by the eldercare service providers. Ideable has developed Kwido, an accessible and user friendly platform for elderly users and utilities focused on their needs and their caregivers’ demands, being the most accessible and usable solution for the growing eldercare market. Currently available Kwido platform is designed for being used mainly by carers at daily centres or in nursing homes. KWIDO@TELECARE, an advanced version of Kwido with new key features, will be the most complete, flexible and revolutionary platform for caring for elderly patients at home, focused on the telecare service providers and their clients (public and private institutions) as customers. It will have a direct impact not only in the global economy, but also in the society, and at the same time will lead Ideable to consolidate itself as a worldwide reference provider of software based telecare and prevention ICT solutions for the elderly. Ideable has already developed all novel features for KWIDO@TELECARE for pilot purposes, but additional effort is needed to fully develop them in large scale and define the business model to successfully exploit it.

Keywords: at home telecare,cognitive stimulation,dementia,alzheimer,social telecare,silver economy,m health,eldercare,healthcare,teleconsultation,social network,big data,wellbeing,aging
Targeting the Human Myocardial Remodeling Process Using Novel Magnetic Force-Based Human Heart Tissue (Magnetic HEART)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Cardiovascular diseases are responsible for the greatest proportion of deaths in people under the age of 70 and cost the EU €110 billion each year. A major cause of heart dysfunction following myocardial infarction is the extensive remodeling of the extracellular matrix (ECM), which leads to the formation of fibrotic scar and death of cardiomyocytes - a collective process known as myocardial remodeling. Diagnosis and treatment of this progressive pathological remodeling process are a top priority in modern healthcare. The project aims to develop novel 3-dimensional (3D) human Magnetic HEART tissue based on unique magnetic nanoparticles (MNPs), and includes two world firsts: (1) a model for long-term live monitoring of ECM remodeling and (2) a new generation of scaffold-free myocardial regeneration techniques. Innovative MNPs will be designed and synthesized to target and specifically label human cardiomyocytes and human cardiac fibroblasts. By applying an external magnetic field, the magnetically labeled heart cells will be accumulated to produce 3D human cardiac tissue, comprising its own biologically-produced ECM, which will offer a practical alternative to native human heart tissue. For the first time, live biochemical changes in cardiac ECM during physiological and pathological remodeling will be monitored using state-of-the-art Raman spectroscopy, which can reveal fundamental insights and improve the basic understanding of this process. This platform, which has not previously been reported, can be translated to treat the remodeled area in the heart by restoring structure and function to the damaged heart tissue, and marks a major breakthrough in magnetic targeting therapy for lesions localized deeper in the body. The outcome of this research has the potential to impact health and society and become a vital component in therapeutic approaches to cardiovascular diseases.

Keywords: myocardial remodeling,cardiac regenerative medicine,magnetite nanoparticles,extracellular matrix turnover,raman spectroscopy
Cybersecurity Threat Detection for Internet of Things Connected Devices (SecIoT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: United Kingdom
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 117843.75
EU funding (EUR): 117843.75
Participants: 1
Project status: CLOSED

Secure Secure Ltd was founded in 2015 and headquartered in the UK. The founding team brings extensive experience in the fields of cybersecurity, scalable software architecture, software company leadership and SME growth. Given the accelerating growth and importance of cybersecurity across many sectors of the economy and society, we have detected and aim to solve the lack of effective security provision in software engineering. Our system automates the vulnerability scanning of software assets and reduces the effort required for development teams to adopt security best practices. Further, our solution reduces costs by 80% compared to hiring consultants for like-for-like tasks. By enabling developers to scan their code before going to production, we can save firms between 3 to 30 times the cost of development, help firms build trust with end-users, empower and educate developers. The company aims to scale up the business towards the area of IoT security by implementing a disruptive innovative solution (taking advantage of the already developed technology) that will definitively allow Secure Secure to increase its competitiveness and internationalisation objectives. While the infrastructure to support the addition of an IoT security sub-product into the suite of Secure Secure’s offering already exists, significant research and development is required in order to realise opportunities for innovation and significant growth. With no similar products on the market the primary objective is to recruit a specialised associate during 12 months to identify and demonstrate the potential research and innovation project the team has detected. This is becoming especially relevant since predictions show a surge in the number of IoT devices, software services and applications that shall form a habitual part of our daily activities in the near and the long term.

Keywords: security,development,vulnerabilities,automation,cybersecurity,internet of things,standards,assesment,education,servers,applications,docker,coding
Clean Refinery Hydrogen for Europe II (REFHYNE II)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Germany,Belgium,Norway,France,United Kingdom,United Kingdom
Call: Develop and demonstrate a 100 MW electrolyser upscaling the link between renewables and commercial/industrial applications (H2020-LC-GD-2020-1, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 148956405.0
EU funding (EUR): 32431618.0
Participants: 11
Project status: SUSPENDED

REFHYNE II will install a 100MW PEM electrolyser at Rheinland refinery in Cologne, Germany, using renewable power to produce green hydrogen and oxygen, which will be fed-in to the existing refinery networks to decarbonise refinery operations. The electrolyser will be based on a state of the art 5MW PEM stack integrated into pre-engineered 20MW electrolyser trains, with factory assembled balance of plant to reduce the amount of bespoke work required to integrate electrolysers into new sites. The project will be delivered by the same team responsible for the REFHYNE project that has installed a 10MW PEM electrolyser at the same site, exploiting the experience of the consortium to deliver a timely and cost-effective project. REFHYNE II will achieve a viable business case for large-scale electrolysis at refineries by valorising the hydrogen and oxygen streams in the refinery and receiving RED credits for the hydrogen produced, while minimising the cost of hydrogen through improvements in efficiency and capital cost. A research task will explore the upgrading of waste heat to higher temperatures for use in the refinery, to further improve the business case. Power will be sourced through novel PPAs with named renewable plants. Emissions avoidance will be achieved by displacing the hydrogen currently produced on-site through SMR and adapting the refinery to allow the electrolyser to act as a flexible load and hence contract direct with renewable generators, to increase renewable penetration into the grid. Research work packages will support the deployment of 100MW+ scale electrolysers at refineries and industrial sites across Europe and enable GW-scale electrolysis systems to be implemented. Finally, a thorough dissemination work package will exploit the results of the project by delivering key messages to target audiences, and supporting three fast follower sites (of which at least two will be located in EU13 countries) to rapidly replicate the results of the project.

Keywords: renewable power,grid balancing,pem electrolyser,refinery decarbonisation,electrolytic oxygen
Damage mechanism of High Frequency Mechanical Impact (HFMI) Treated Welded Structures under Service Loading to Increase the Fatigue Life for Lightweight Design (Hi-Life)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

The use of high-strength steel (HSS) grades leads to significant weight reduction and increased service life, especially in complex-welded structures. However, their implementation is limited in practice due to the fatigue issues at welds, welds which have the same fatigue life as those in lower strength steels. High-frequency mechanical impact (HFMI) treatment allows for important fatigue life improvement based on the induced compressive residual stress (RS), improved weld shape and cold-worked surface region. In current drafted guidelines, these factors were derived according to the weld toe failures obtained under constant amplitude loading (CAL) and also verified by a limited dataset under variable amplitude loading (VAL), the latter being more realistic of service loadings. Current knowledge on HFMI-improved welds has also shown that fatigue failures may also initiate at other regions, rather than weld toe. In spite of the fact that relaxation of induced RS state has been claimed to be the main reason of different damage mechanisms resulting in the failure location change, scientific questions such as: why, how and under what conditions this effect occurs or what damage mechanisms play a dominant role, remain unanswered. Based on the above context, the objective of this proposed project aims to solve the damage mechanisms of HFMI-treated welds under service loading by considering fatigue tests, investigating the microstructures and developing analytical approaches. The proposed scientific approach includes investigations on the development of grain structure size/orientation through the depth of HFMI groove by neutron scattering, and on the relation of grain-orientation-dependent RS state under service loading. This training will also allow transferring of the obtained knowledge obtained to the industrial partner for the implementation of this novel treatment technique by utilizing HSS in the shipyard.

Keywords: fatigue strength improvement,high frequency mechanical impact treatment,high strength steel,damage mechanism,lightweight design
Next level real-time characterisation of Li- and Na-ion batteries by – Automatic Tuning Matching Cycler (plus Goniometer) – ATMC(+G) in situ NMR (ATMCinsituNMR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-03-01
End date: 2017-02-28
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Concerns about finite energy resources and the need to decrease greenhouse gas emissions have increased the use of intermittent renewable energies on the electric grid. This is not without its challenges requiring more efficient ways to store electrical energy to balance demand with supply. Li-ion batteries (LIBs) are the most desirable form of energy storage (high energy / power densities) but an increasing demand of Li commodity chemicals combined with geographically-constrained reserves will drive up prices in the future. Due to the high abundance, low costs and very suitable redox potential, Na-ion batteries (NIBs) should open new avenues of research and engineering as complementary alternatives to LIBs. This shift has to be accompanied with a deeper understanding of the chemical reactions involving the multiple cell components. The proposed project focuses on a next step of in situ NMR spectroscopy, offering the unique possibility of non-invasive real-time studies of batteries under operating conditions – to track the formation of intermediate phases and investigate electrolyte decomposition during cycling of LIBs and NIBs. Significantly different shifts of the multi-component samples, resonance broadening as well as interferences of the NMR and external battery cycler (EBC) circuit impair the experiments. Hence, we will set up a novel NMR probe system allowing “on-the-fly” adjustment of the NMR circuit during the measurement and sample orientation changes via an automated goniometer. Moreover, an entirely new NMR-EBC-connection design will benefit the real-time experiments. This next level Automatic Tuning Matching Cycler (plus Goniometer) – ATMC(+G) – in situ NMR approach will be established in a comparative study on lithium vs. sodium iron phosphate cathodes in LIBs and NIBs, respectively, including the application of new electrolytes to improve battery safety and cost factors. The application to a wider range of systems will include Na-Sn anodes for NIBs.

Keywords: energy storage,energy materials,lithium ion batteries,sodium ion batteries,in situ nmr,automating,paramagnetism,bms effect,lifepo4,nafepo4,naxsn
Uncovering the Mutual Shaping of Hydrological Extremes and Society (HydroSocialExtremes)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2023-03-31
Duration (months): 60.0
Total project cost (EUR): 1835361.25
EU funding (EUR): 1835361.0
Participants: 1
Project status: CLOSED

More than 100 million people per year are affected by hydrological extremes, i.e. floods and droughts. Hydrological studies have investigated human impacts on droughts and floods, while conversely social studies have explored human responses to hydrological extremes. Yet, the dynamics resulting from their interplay, i.e. both impacts and responses, have remained poorly understood. Thus, current risk assessment methods do not explicitly account for these dynamics. As a result, while risk reduction strategies built on these methods can work in the short-term, they often lead to unintended consequences in the long-term. As such, this project aims to unravel the mutual shaping of society and hydrological extremes. A combined theoretical and empirical approach will be developed to uncover how the occurrence of hydrological extremes influences society’s wealth, institutions and population distribution, while, at the same time, society in turn alters the frequency, magnitude and spatial distribution of hydrological extremes via structural measures of water management and disaster risk reduction. To explore the causal mechanisms underlying this mutual shaping, this project will propose explanatory models as competing hypotheses about the way in which humans drive and respond to droughts and floods. These alternative explanations will be developed and tested through: i) empirical analysis of case studies, and ii) global investigation of numerous sites, taking advantage of the current unprecedented proliferation of worldwide datasets. By combining these different methods, this project is expected to address the gap of fundamental knowledge about the dynamics of risk emerging from the interplay of hydrological extremes and society.
QUAntum nanophotonics in Rolled-Up Metamaterials (aQUARiUM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Finland
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 1499431.0
EU funding (EUR): 1499431.0
Participants: 2
Project status: SIGNED

Novel sophisticated technologies that exploit the laws of quantum physics form a cornerstone for the future well-being, economic growth and security of Europe. Here photonic devices have gained a prominent position because the absorption, emission, propagation or storage of a photon is a process that can be harnessed at a fundamental level and render more practical ways to use light for such applications. However, the interaction of light with single quantum systems under ambient conditions is typically very weak and difficult to control. Furthermore, there are quantum phenomena occurring in matter at nanometer length scales that are currently not well understood. These deficiencies have a direct and severe impact on creating a bridge between quantum physics and photonic device technologies. aQUARiUM, precisely address the issue of controlling and enhancing the interaction between few photons and rolled-up nanostructures with ability to be deployed in practical applications. With aQUARiUM, we will take epsilon (permittivity)-near-zero (ENZ) metamaterials into quantum nanophotonics. To this end, we will integrate quantum emitters with rolled-up waveguides, that act as ENZ metamaterial, to expand and redefine the range of light-matter interactions. We will explore the electromagnetic design freedom enabled by the extended modes of ENZ medium, which “stretches” the effective wavelength inside the structure. Specifically, aQUARiUM is built around the following two objectives: (i) Enhancing light-matter interactions with single emitters (Enhance) independent of emitter position. (ii) Enabling collective excitations in dense emitter ensembles (Collect) coherently connect emitters on nanophotonic devices to obtain coherent emission. aQUARiUM aims to create novel light-sources and long-term entanglement generation and beyond. The envisioned outcome of aQUARiUM is a wholly new photonic platform applicable across a diverse range of areas.

Keywords: metamaterials,epsilon near zero,quantum nanophotonics,rolled up structures,quantum dots