Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Regeneration and Optimisation of Cultural heritage in creative and Knowledge cities (ROCK)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Cultural heritage
Action type: Innovation actions
Countries involved: Spain,Italy,Italy,Italy,Italy,Spain,Germany,Spain,Belgium,Romania,North Macedonia,Greece,Lithuania,Switzerland,Romania,France,Netherlands,United Kingdom,Portugal,United Kingdom,United Kingdom
Call: Cultural heritage as a driver for sustainable growth (H2020-SC5-2016-TwoStage, 2016)
Start date: 2017-05-01
End date: 2020-12-31
Duration (months): 44.0
Total project cost (EUR): 10629453.26
EU funding (EUR): 9873585.870000001
Participants: 38
Project status: CLOSED

ROCK aims to develop an innovative, collaborative and circular systemic approach for regeneration and adaptive reuse of historic city centres. Implementing a repertoire of successful heritage-led regeneration initiatives, it will test the replicability of the spatial approach and of successful models addressing the specific needs of historic city centres. ROCK will transfer the Role Models blueprint to the Replicators, adopting a cross-disciplinary mentoring process and defining common protocols and implementation guidelines. ROCK will deliver new ways to access and experience Cultural Heritage [CH] ensuring environmental sound solutions, city branding, bottom-up participation via living labs, while increasing liveability and safety in the involved areas. ICT sensors and tools will support the concrete application of the ROCK principles and the interoperable platform will enable new ways to collect and exchange data to facilitate networking and synergies. The added value is the combination of sustainable models, integrated management plans and associated funding mechanisms based on successful financial schemes and promoting the creation of industry-driven stakeholders’ ecosystems. A monitoring tool is set up from the beginning, running during two additional years after the project lifetime. Main expected impacts deal with the achievement of effective and shared policies able to: accelerate heritage led regeneration, improve accessibility and social cohesion, increase awareness and participation in local decision making process and wider civic engagement, foster businesses and new employment opportunities. Involving 10 cities, 7 Universities, 3 networks of enterprises, 2 networks of cities and several companies and development agencies, a foundation and a charity, ROCK is able to catalyse challenges and innovative pathways across EU and beyond, addressing CH as a production and competitiveness factor and a driver for sustainable growth.

Keywords: sustainable historic city centre,creative and knowledge cities,heritage as common good,green transition,social inclusion,co design,ch accessibility
Nanopores for New Molecular Nitrogen Chemistry (NANOCHEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-06-01
End date: 2022-11-30
Duration (months): 66.0
Total project cost (EUR): 2498645.0
EU funding (EUR): 2498645.0
Participants: 1
Project status: CLOSED

We will study the adsorption, binding, transport and reactivity of N-containing substrates within the nanopores of functionalized and doped metal-organic framework (MOF) materials. A range of important target molecules (e.g., NH3, N2H4, N2O, NO, NO2 and N2O4) will be studied in this project, which aims to re-define the molecular chemistry for these energetic N-compounds in confined space, and to develop selective catalytic reduction (SCR) of NOx in the presence of NH3, urea and hydrocarbons. The PI has extensive experience in the field of coordination chemistry and hybrid materials, and seeks to change research direction to develop new gas phase catalysts and to gain fundamental understanding of molecular interactions, properties and function of specific energy, environmentally-related substrates within MOFs. Research objectives include the: • Design and synthesis of new porous MOFs with emphasis on the decoration of their pore environment and improvement of their structural stability and function; • Characterisation of host and substrate-loaded materials by state-of-the-art in situ structural, dynamic and spectroscopic methods for the construction of structure-function relationships, supported by computational analysis and modelling; • Adsorption, binding, release and separation of NH3, N2H4, N2O, NO, NO2 and N2O4 via both static and dynamic experiments; • Tests of degradation and selective catalytic reduction (SCR) of captured NOx molecules with NH3, urea and hydrocarbons under mild conditions using nanoporous MOFs as host catalysts; • Assembly of a MOF-based (i) catalytic deNOx reactor and (ii) NH3 storage system for potential portable applications. This project will deliver new functional materials as high capacity portable NH3 stores, efficient capture medium for NOx, and new catalysts for reduction and mitigation of NOx to deliver significant impacts to academia, industry and society of direct relevance to clean energy and sustainable environment.

Keywords: metal organic framework materials,catalysis
Market Design for a Decentralized Integrated European Energy Transformation (NRGcitizens)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: SIGNED

The European Commission, with its "Clean Energy for all Europeans" package, calls for stronger participation of residential electricity consumers—individually or through communities—in the energy value chain, that is, production and sharing as well as flexible and responsive demand. While European legislation is promoting the end user of electricity (and therewith, both, the consumer and so-called prosumer) as a key player in the future market, national regulation is often not proceeding fast enough in this transition process. While pilot projects in many countries have shown the technical and economic feasibility of energy communities in Europe and around the world, the impact of widespread implementation on existing markets remains unclear. In theory, these local electricity markets could form a bridge between decentralized electricity production and wholesale electricity exchanges as well as driving investments in distributed energy resources without governmental subsidies. Yet, research on local market designs and associated features developed on the basis of pilot projects is still in an early stage, especially in regard to regulatory and economic frameworks. Subsequently, there is a mismatch between developed market designs and their feasibility in the current regulatory framework. The project NRGcitizen will therefore address the following research questions: What are advantages and disadvantages of a decentralized energy transformation from a system perspective? How could organizational models be designed and what business models arise in energy communities? What are possible market designs for a 100% renewable energy transformation, integrating the heating and transportation sectors? Techno-economic modeling will be used to quantitatively assess those designs. The project will enlarge policymakers’ toolbox for the analysis of energy markets to assess the value of decentralized small-scale production and flexibility, thereby making it highly policy-relevant.

Keywords: electricity market design,energy communities,local energy sharing,peer to peer trading,energy systems integration
The Brexit effect in media coverage: how the intra-party democracy counters the rise of European populism (POSTBREXIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Action type: Marie Skłodowska-Curie actions
Countries involved: United Kingdom
Call: MSCA Special Needs Allowance (H2020-IBA-MSCA-SNLS-2020, 2020)
Start date: 2021-01-01
End date: 2022-06-30
Duration (months): 18.0
Total project cost (EUR): 12905.0
EU funding (EUR): 12905.0
Participants: 1
Project status: CLOSED

Request of financial support to cover the additional costs that researchers/staff members with disabilities face due to the increased costs of their mobility and/or to ensure necessary assistance by third persons or for adapting their work environment.

Keywords: brexit,populism,euroscepticism,europe,intra party democracy
Simultaneous detection of carbon monoxide and viscosity changes in cells using bimetallic fluorogenic probes (COVISENSE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Despite its toxic reputation, carbon monoxide (CO) is also an important biological messenger molecule that regulates many vital cell processes, including the response to disease. Increased enzymatic generation of carbon monoxide plays a critical role in the resolution of inflammatory processes and alleviation of cardiovascular disorders. At the same time, altered viscosity levels have been associated with inflammation, including in cardiovascular disease. Since the diffusion-controlled movement of carbon monoxide is also affected by changes in the viscosity of the cellular environment, the two aspects are intimately connected. Therefore, the simultaneous measurement of both carbon monoxide and cellular viscosity would provide unprecedented information on the functioning of the cell and the state of inflammation and disease. We propose to achieve this through a new family of bimetallic ruthenium(II) molecular probes capable of monitoring both endogenous carbon monoxide (using fluorescence intensity) and the viscosity in the cellular environment (through fluorescence lifetime). These highly selective probes would show very low detection limits for CO and operate within the ‘biological window’ above 650 nm. At the same time, internal rotation of the BODIPY fluorophore would allow fluorescence lifetime imaging microscopy (FLIM) to be used to monitor the local viscosity. Through a collaboration with immune-oncologists, the probes will be used to expand the understanding of the role played by the enzyme, haem oxygenase (HO-1), that produces CO. This could help illuminate the association between HO-1 expression and poor prognosis in cancer patients. The project will combine ligand design, organometallic synthesis, fluorescence imaging and cell work, providing the opportunity to gain experience in a range of areas related to sensing in biological environments.

Keywords: metal complexes,sensing,carbon monoxide
Dynamic hormone diagnostics (ULTRADIAN)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Norway,Sweden,Sweden,Greece,United Kingdom,United Kingdom
Call: Development of new diagnostic tools and technologies: in vitro devices, assays and platforms (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-09-01
End date: 2020-02-29
Duration (months): 54.0
Total project cost (EUR): 5999381.25
EU funding (EUR): 5999381.0
Participants: 8
Project status: CLOSED

We propose to revolutionize current endocrine diagnostics by replacing conventional, time-consuming single-analyte hormone assays with ambulatory dynamic endocrine diagnostics. Disorders of the adrenal and pituitary endocrine systems are not only accompanied by changes in absolute hormone levels, but also secretion patterns. The rapid circadian (24 hour) and ultradian (< 24 hour) cycling of hormone levels poses diagnostic challenges since random measurements do not always detect abnormalities. Furthermore, monitoring of treatment of endocrine diseases are often severely limited by lack of multiple measurements at different time points, which is impractical in an out-patient setting. To overcome these hurdles academic and commercial partners propose to: • Develop a novel microdialysate sampling and analysis system for adrenal and pituitary hormonome profiling • Validate the method in healthy vs. six populations with endocrine disorders • Promote the system for demonstration in routine clinical practice by dissemination of results to relevant European stakeholders The portable fraction collector for subcutaneous microdialysate combined with state-or-the-art ultrasensitive assays by liquid chromatography tandem mass spectroscopy (LCMS/MS) and multiplex proximity extension assays (Proseek), will allow collection of 10 minute fractions for up to 72 hours while the person tends to daily life activities. LCMSMS and Proseek assays can generate a timeline of “hormonomes” covering the 24 hour cycle without losing sensitivity and specificity, producing not only hormone levels, but also secretion patterns for diagnostics and monitoring purposes. ULTRADIAN will deliver an ambulatory diagnostic system with unprecedented sensitivity and specificity for simplified diagnostics and monitoring of endocrine conditions, economisation of health care, and new products and markets for the European diagnostic sector.

Keywords: cushing s syndrome,acromegaly,cortisol,aldosterone,liquid chromatography,immunoassay
Create a business plan for implementing the data-analysis software DatenBerg Backpack in the manufacturing site in the rubber processing industry. (DBP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-07-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Started with the first place at the Audi Smart Factory Hackathon and Audi as a first customer, DatenBerg is entering the manufacturing market with its machine-learning software. DatenBerg is driven by its mission: Simplify complex production processes. DatenBerg means “Data Mountain” in German and that is exactly, what it is all about: analyzing “mountains” of data to create valuable input. The company provides a holistic scalable software solution for the manufacturing industry. The automated data-analysis software, called DatenBerg Backpack, enables the customers to identify hidden correlations in their production process. DatenBerg was founded in February 2018 and is today, mainly focusing on the rubber processing sector. The company is going to launch the beta version of DatenBerg Backpack in March 2019. The team consists of five team members with more than 50 years of experience in the manufacturing industry in total. During the feasibility study, the first implementations of Backpack in the rubber processing industry will be accompanied and the business plan for the implementation of the software will be further developed.

Keywords: industry 4 0,smart factory,predictive analytics,predictive quality
Epigenetic regulation of cell fate during early mammalian development (EpiCellLineage)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 2351249.0
EU funding (EUR): 2351249.0
Participants: 1
Project status: TERMINATED

Formation of the three primary germ layers during gastrulation is an essential step in the establishment of the vertebrate body plan. Single cell RNA-sequencing has identified major transcriptional changes associated with germ layer specification. Global epigenetic reprogramming accompanies these changes, but the role of the epigenome in regulating early cell fate choice is poorly understood. We are systematically charting this important developmental progression by single cell multi-omics, tracking simultaneously the transcriptome, DNA methylome and chromatin accessibility. We find that promoters or enhancers of lineage specific genes are epigenetically primed at early developmental stages to safeguard their future transcriptional activation. We have identified DNA binding proteins needed for multi-lineage priming of regulatory elements prior to gastrulation. Here, we will determine the molecular mechanisms of epigenetic priming, and the functional consequences of faulty priming in lineage and organ development. The first objective addresses how the DNA binding proteins DPPA2,4 target chromatin bivalency (H3K4me3 and H3K27me3) to developmental gene promoters, and the consequences of bivalency loss in vivo. The second objective characterises neuroectoderm enhancer priming which occurs already in the early epiblast, and identifies DNA binding proteins and chromatin complexes which prime these enhancers, preparing them for future gene activation. The third objective uses large-scale combinatorial epigenetic editing of promoters and enhancers in vitro and in vivo to determine their impact on cell fate decisions in gastrulation and early organogenesis. This ambitious programme of work will provide fundamental insights into how the epigenetic landscape in early development impacts cell differentiation. Our discoveries will inform strategies for ES or iPS cell based regenerative medicine, and improve our understanding of how developmental disorders arise in humans.

Keywords: epigenetics,epigenome,single cell multi omics,gastrulation,cell fate,enhancers,promoters,bivalency,transcription,dna methylation,epigenetic editing,early mammalian development,chromatin
At the epigenetics-cancer metabolism interface (EPICAMENTE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Spain
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-11-01
End date: 2025-10-31
Duration (months): 72.0
Total project cost (EUR): 1996904.0
EU funding (EUR): 1996904.0
Participants: 1
Project status: SIGNED

Epigenetic regulation and metabolism are of great interest in cancer research. However, physical and functional connections between these two areas remain largely unexplored. While it is commonly believed that metabolites can randomly distribute inside the cell, recent evidence rather favors the hypothesis that production of certain metabolites in specific subcellular compartments orchestrates different cellular processes. EPICAMENTE aims at exploring whether the localization of enzymatic activities on chromatin can integrate cancer metabolism with chromatin remodeling to control epigenetic regulation and tumor progression. First, I aim at providing a dataset of chromatin-bound metabolic enzymes in a comprehensive panel of cancer cell lines. By combining a chromatin fluorescent reporter cell line strategy with epigenomic approaches, I will define the epigenetic and transcriptional scenarios orchestrated by chromatin-bound metabolic enzymes, and investigate their relevance in cancer cell proliferation. Performing genetic screenings with the chromatin fluorescent reporter cell lines will allow the identification of genetic interactors mediating the epigenetic role of chromatin-bound metabolic enzymes. In parallel, I aim to screen for small molecules able to counteract the epigenetic states mediated by those metabolic enzymes. Finally, I will validate my results in in vivo cancer models, thus adding an important translational aspect to the project, and opening up new opportunities for cancer therapy. The success of this project can impact our fundamental understanding of cellular and cancer biology. In most cases, the belief is that intracellular materials reside inside steady-state membrane-based compartments, which limit the interactions between different molecular pathways. By describing the role of chromatin-bound metabolic enzymes and discovering direct connections between cancer metabolism and epigenetic regulation, I will scrutinize this belief.

Keywords: cancer metabolism,genetic screening,small molecule screening,drug repurposing