Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
An integrated framework to investigate the genetics of changing environments (CHENGEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

An important scientific challenge this century is to understand how biodiversity responds and adapts to global environmental change so we can predict and prepare for the effects of major conservation threats. Future climate change will produce a range of new selection pressures on populations due to increased temperatures, droughts and extreme events, while continuing anthropogenic habitat loss is likely to exacerbate pressures and limit future range shifts. The ‘CHENGEN’ project aims to establish a novel multidisciplinary framework for understanding and predicting the responses of biodiversity to environmental change by integrating genomic tools with ecological, spatial, demographic and mathematical modelling. Societal impacts are at the heart of this project, and its main aim is to provide the evidence base for protecting and sustainably managing biodiversity. The project focuses on threatened European forest bats as indicators of biodiversity responses to environmental change. Project objectives are to initiate cross-European collaborations to evaluate the effect of environmental changes on species’ ranges, generate genomic resources to study evolutionary adaptations, develop novel modelling tools to assess survival prospects and landscape barriers to range shifts, and provide conservation management solutions. Objectives will be achieved through predictive distribution modelling for all European forest bats (WP1) and a population genomics study of an endemic Iberian forest bat, Myotis escalerai (WP2-3). Beyond enabling European research mobility, the project will provide training in state-of-the-art research skills by world leading experts within the host institution’s multidisciplinary research environment. Knowledge transfer will strengthen genomic research in the host institution and bring a new evolutionary perspective to the study of environmental change, paving the way towards future collaborations and the applicant’s independent research career.

Keywords: global change,genetic adaptations,landscape genomics,ecological modelling,geographic information systems,land use changes,range shifts,population viability analysis
R-loops as a major modulator of transcription-associated recombination and chromatin dynamics (TARLOOP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-12-01
End date: 2021-11-30
Duration (months): 72.0
Total project cost (EUR): 2312500.0
EU funding (EUR): 2312500.0
Participants: 1
Project status: CLOSED

Understanding the causes of genome instability, a condition linked to cancer and cancer-prone genetic diseases, is a major question in Molecular Biology and Biomedicine. Probably the most important natural cause of genome instability is transcription, which is known to induce both mutation and recombination from bacteria to human cells. Different studies suggest that transcription-associated recombination (TAR) is in large part due to collisions between transcription and replication, but increasing evidence indicate that R-loops, formed by a DNA-RNA hybrid and a displaced single-stranded DNA, may be a major determinant of genome instability. This is of particular relevance, provided our recent observation that tumor suppressor BRCA2 gene is involved in R-loop prevention/resolution and that, therefore, R-loops may represent a major potential source of tumorigenesis. The goal of this project is to understand the mechanisms of R-loop dynamics by identifying the functions and elements acting in cis and trans, that is, the DNA sequences and genes controlling R-loop formation and removal. The project will be based on a multidisciplinary approach using Saccharomyces cerevisiae and human cell lines. We plan: a) to identify the proteins and mechanism that actively works in the formation and prevention of intermediates responsible for R-loop-mediated TAR; b) to define the histone residues linked to R-loop formation and its role in chromatin dynamics, and c) to establish how the different trans and cis elements control genome-wide R-loop–mediated genome instability whether or not in association with replication fork impairment, double-strand break accumulation, chromatin structure and mRNP biogenesis and export. The functional relevance of selected conserved genes will be validated in Caenorhabditis elegans as a model organism. The long-term objective of the proposal is to decipher the mechanisms by which R-loops modulate chromatin dynamics and genome instability.

Keywords: genome instability,double strand break repair
Market uptake of Solar Thermal Electricity through Cooperation (MUSTEC)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Austria,Spain,Germany,Germany,Belgium,Switzerland,Greece
Call: Market uptake of renewable energy technologies (H2020-LCE-2017-RES-CSA, 2017)
Start date: 2017-10-01
End date: 2021-03-31
Duration (months): 42.0
Total project cost (EUR): 2396526.13
EU funding (EUR): 2396526.13
Participants: 10
Project status: CLOSED

IIn the light of the EU 2030 Climate and Energy framework, MUSTEC aims to explore and propose concrete solutions to overcome the various factors that hinder the deployment of concentrated solar power (CSP) projects in Southern Europe capable of supplying renewable electricity on demand to Central and Northern European countries. To do so, the project will analyze the drivers and barriers to CSP deployment and renewable energy (RE) cooperation in Europe, identify future CSP cooperation opportunities and will propose a set of concrete measures to unlock the existing potential. To achieve these objectives, MUSTEC will build on the experience and knowledge generated around the cooperation mechanisms and CSP industry developments building on concrete CSP case studies. Thereby we will consider the present and future European energy market design and policies as well as the value of CSP at electricity markets and related economic and environmental benefits. In this respect, MUSTEC combines a dedicated, comprehensive and multi-disciplinary analysis of past, present and future CSP cooperation opportunities with a constant engagement and consultation with policy makers and market participants. This will be achieved through an intense and continuous stakeholder dialogue and by establishing a tailor-made knowledge sharing network. The MUSTEC consortium consists of nine renowned institutions from six European countries and includes many of the most prolific researchers in the European energy policy community, with very long track records of research in European and nationally funded energy policy research projects.

Keywords: renewable regional cooperation
Advanced Theranostic Nanomedicines for Oncology. Development of new combinatorial therapies for primary and metastatic Breast Cancer. (ONCOTHERANOSTICS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-03-01
End date: 2022-02-28
Duration (months): 36.0
Total project cost (EUR): 257191.2
EU funding (EUR): 257191.2
Participants: 2
Project status: CLOSED

Despite significant advances in recent years, cancer remains the 2nd cause of death globally. Immunotherapy is an exciting new therapeutic approach that triggers natural immune response against cancer cells. Theranostics is an emerging therapeutic intervention, that uses dual (or multiple) purpose nanomedine, combining diagnostic and therapeutic effects within a single multifaceted formulation. ONCOTHERANOSTICS proposes the use of a novel theranostic agent to target key tumoral genes by siRNA and monitor the impact of the downregulation non-invasively in vivo. Specific aims include understanding the interplay between choline kinase and tumor escaping natural immune surveillance, and to develop new combinatorial therapies in a model of primary and metastatic triple negative breast cancer. We anticipate that successful completion of the project will result in significant advances in personalized tumor treatments, rendering safer strategies to treat cancer with a dual effect; boosting natural immune response and knocking down one of the main mechanisms of malignancy. Dr. Pacheco is an organic chemist with expertise in MRI who will be trained (outgoing) in nanoparticle synthesis, non-MRI imaging techniques and advanced molecular biology/genetic approaches. Training will be transferred to the host European institution (incoming) by the establishment of a new research line in the emerging field of Theranostics. ONCOTHERANOSTICS seeks to improve our understanding of cancer and how to personalize treatments, fostering the development of nanomedicine targeting specific genes in a way that can be assessed non-invasively. ONCOTHERANOSTICS provides a multidisciplinary environment for cancer treatment, involving multifaceted nanomedicine, multimodal molecular imaging and molecular biology/genetic approaches. The proposal directly addresses the cross cutting priority of personalizing health and care established by H2020, reinforcing European competitiveness in cancer research.

Keywords: cancer,gene silencing,image guided drug delivery,immune checkpoints,molecular imaging,metabolism,nanomedicines,small interfering rna sirna,theranostics
RESPONSIBLE RESEARCH AND INNOVATION APPROACH FOR TRANSITIONING THE TRADITIONAL INDUSTRY REGIONS INTO DIGITALISED INDUSTRY TERRITORIES. (DigiTeRRI)

Framework: Horizon 2020 — Science with and for Society
Programme: Integrate society in science and innovation issues, policies and activities in order to integrate citizens' interests and values and to increase the quality, relevance, social acceptability and sustainability of research and innovation outcomes in various fields of activity from social innovation to areas such as biotechnology and nanotechnology
Action type: Coordination and support actions
Countries involved: Austria,Spain,Austria,Sweden,Norway,France,France,France
Call: Supporting the development of territorial Responsible Research and Innovation (H2020-SwafS-2019-1, 2019)
Start date: 2020-01-01
End date: 2022-12-31
Duration (months): 36.0
Total project cost (EUR): 2004037.5
EU funding (EUR): 2004037.5
Participants: 12
Project status: CLOSED

The project develops a framework for a responsible transition of traditional industry regions into digitalised industry R&I ecosystems. The elaboration of this framework will be performed together with the impacted industries, the influential territorial authorities, and the affected citizens. The creation of strategies and a concept will be conducted for implementing resilient R&I ecosystems for digitalised industries in traditional industry territories. Resilient R&I ecosystems requires taking into account a high degree of openness, democratic accountability, and responsiveness to the needs of the addressed industries and society in the considered regions.

Keywords: self sustaining randi ecosystems,transitioning traditional regions into digitalised industrial territories,regional development,v rmland se,r gion grand est fr,styria at
Multimodal imaging in parkinsonisms: from the molecular synaptic pruning to the whole-brain connectomics (SYNPARK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 232497.6
EU funding (EUR): 232497.6
Participants: 2
Project status: CLOSED

Neurodegenerative diseases affect more than 6 million people in Europe, and its prevalence is growing as population ages, hence it is a timeliness health challenge we are facing as a society. Parkinsonism is the 2nd most prevalent neurodegenerative form, being Parkinson’s disease (PD) the most frequent, whereas 20% of the patients are diagnosed with atypical parkinsonisms (AP). Despite presenting some clinical overlap, AP tends to be more therapy-resistant and have faster degeneration rates than PD. SYNPARK is an interdisciplinary project that will investigate the discriminative power of different imaging markers’ modalities in parkinsonisms. Improving diagnostic accuracy is crucial as disease-modifying therapies are becoming available for PD. For this challenge, I propose a multidisciplinary approach: from the in-vivo synaptic molecular brain assessment (using positron emission tomography, PET), the whole-brain connectomics organisation (using magnetic resonance imaging, MRI) to the clinics. I will conduct the outgoing phase in one of the world’s PET leading centres in Toronto to test the clinical validity of a new generation PET tracer in AP/PD. My host return institution (Barcelona) has pioneered the research on machine learning (ML) techniques that are revolutionising the medical sciences field to improve parkinsonisms’ differential diagnosis at the single-patient level by means of whole-brain MRI connectomics information. My current expertise and the proposed ambitious training objectives will position me at the forefront of this exciting new avenue in medical sciences and will enhance my professional independence for research leadership. Overall, the synergies established between these two leading centres are expected to have a tremendous impact on the understanding of AP/PD brain pathophysiology and its diagnostic accuracy, and ultimately enhancing a revolution in personalised medicine, a futuristic therapy that is increasingly becoming a reality.

Keywords: structural mri connectivity,functional mri connectivity,positron emission tomography,atypical parkinsonism
calScreener® – an innovative device for Bacterial Analysis and Diagnostics through Growth and Energy-release in Real-time (BADGER)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Sweden
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-07-01
End date: 2016-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The overall objective of the project is to commercialize calScreener™ - the first multi-channel calorimetry system for Antimicrobial Susceptibility Testing (AST). The clinical importance of AST tests is increasing in line with the growing concerns over antimicrobial-resistant infections. De-spite the vast amount of research that has been done to improve AST testing standards globally, there are several clinical areas where the testing cannot be performed due to the lack of proper monitoring/assay technologies. An example is Biofilm Infections where no diagnostic standards exist. Through the project, SymCel will propose calScreener™ , a calorimetry based diagnostic tool, as a novel and viable approach to target unmet diagnostic needs. The key need of clinicians dealing with bacterial infections is an accurate and quick diagnostic test that will help to determine if and what type of antibiotic should be used in the patient. The test should be objective and actionable, i.e. providing information at the choice of therapy. calScreener™ will meet those needs by delivering detailed and correct information about the type of bacteria involved in the infection enabling quick choice of individualized patient therapy. In the Phase 1 project, SymCel will develop a business plan that will guide the upcoming validation and exploitation efforts. By validating and commercializing calScreener™ as a diagnostic tool, the BADGER project will make an important contribution to fighting anti-microbial resistance in Europe, and increase the level of Antibiotic Stewardship.

Keywords: antimicrobial susceptibility testing,calorimetry based clinical diagnostics,antibiotic stewardship
Quantum limited probing of many-body systems (QuProbe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: SIGNED

An efficient readout of the available information is the key ingredient for understanding many-body systems when performing quantum simulations. In quantum systems every extraction of information implies a backaction altering the system’s state. The main objective of this proposal is to develop and experimentally apply minimum disturbing and quantum limited probes for many-body quantum systems. We aim at understanding the influence of measurement backaction onto many-body systems. We will combine techniques known from the field of ultracold atoms, quantum optics, and biological imaging with our expertise on many-body quantum systems. Ultracold bosonic quantum gases in one-dimensional trapping potentials are used to study fundamental open problems in the realm of quantum many-body systems. The probing is performed in two ways: Interferometric schemes with off-resonant light are used to implement local weak measurements. Outcoupling of few atoms allows us to realize weak probing of the quantum system. Both methods will allow for local probing and spatially resolved readout. We will perform benchmarking measurements with many-body systems studying the quantum backaction. With the new methods at hand, we will investigate the role of controlled openness for isolated many-body quantum dynamics. Further, our methods will for the first time allow the measurement of a fluctuation-dissipation relation with ultracold atoms. The project is relevant for the Horizon 2020 program as it will offer new possibilities to study large quantum systems which are fundamentally important for future quantum technologies. The insights will be of importance beyond the ultracold atoms community and trigger and enable research also in different fields as for example biological imaging.
Protocols and Strategies for extending the useful Life of major capital investments and Large Industrial Equipment (LEVEL-UP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Innovation actions
Countries involved: Austria,Germany,Germany,Spain,Spain,Italy,Italy,Italy,Italy,Germany,Germany,Spain,Italy,Spain,Italy,Italy,Spain,Finland,Switzerland,Slovenia,Greece,Switzerland,Greece,France,Czechia,Czechia,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal
Call: Refurbishment and re-manufacturing of large industrial equipment (IA) (H2020-NMBP-FOF-2019, 2019)
Start date: 2019-10-01
End date: 2023-09-30
Duration (months): 48.0
Total project cost (EUR): 16904150.98
EU funding (EUR): 14027950.26
Participants: 45
Project status: SIGNED

Europe is still lacking an efficient systemic multi-level approach that enables a recursive, cost-effective, holistic and integrated application of circular principles to the digital uplifting of factory 4.0 capital investments; addressing issues at product, process, system as well as the entire value-chain levels, integrating best practices from emerging enabling digital technologies and avoid a two speed digital transformation across industries in different sectors. LEVEL-UP will offer a scalable platform covering the overall lifecycle, ranging from the digital twins setup, modernisation actions to diagnose and predict the operation of physical assets, to the refurbishment and remanufacturing activities towards end of life. In-situ repair technologies and the redesign for new upgraded components will be facilitated through virtual simulations for increased performance and lifetime. LEVEL-UP will therefore comprise new hardware and software components interfaced with the current facilities through IoT and data-management platforms, while being orchestrated through eight (8) scalable strategies at component, work-station and shopfloor level. The actions for modernising, upgrading, refurbishing, remanufacturing, and recycling will be structured and formalised into ten (10) special Protocols, linked with an Industrial Digital Thread weaving a seamless digital integration with all actors in the value chain for improved future iterations. LEVEL-UP will be demonstrated in 7 demo sites from different sectors. The impact of LEVEL-UP to the European manufacturing industry, but also the society itself, can be sum-marised in the following (with a horizon of 4 years after project ends): (i) increase of the material and re-source efficiency by 11.5%, (ii) increased reliability by 16% of the equipment in an extended lifetime by 20%, (iii) over 50% increase of the Return on Investment (ROI), (iv) about 810 new jobs created and (v) over 80M EUR ROI for the consortium.

Keywords: refurbishment,remanufacturing,cognitive manufacturing,digital thread,marketplace 4 0,factory 4 0,maintainability,extended lifetime of large equipment,virtual refurbishment,virtual twin