Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Genetic study of Common Hereditary Bowel Cancers in Hispania and the Americas (CHIBCHA)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: United Kingdom,Colombia,Mexico,Brazil,Spain,Spain,Portugal,Uruguay,Argentina,United Kingdom
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-06-01
End date: 2013-05-31
Duration (months): 48.0
Total project cost (EUR): 3956917.74
EU funding (EUR): 2974288.0
Participants: 10
Project status: CLOSED

Colorectal cancer (CRC) is common in both sexes, has relatively poor outcome and has no major avoidable risk factor. Recent studies have shown that common inherited single nucleotide polymorphisms (SNPs) can increase cancer risk. We have shown CRC risk to be associated with SNPs on chromosomes 8q24.21, 15q14 and 8q21. These variants account for <5% of the genetic risk of CRC, but will be very important when their effects are added to those of other, as-yet undetected CRC SNPs. A few genome-wide association studies (GWASs) based on populations of European descent are trying to identify the remaining common CRC genes. Evidence suggests that these studies will not be large enough on their own to detect all CRC SNPs, as: relative risks associated with most SNPs are modest; some disease alleles are rare, at least in Europe; and many variants may lie outside conventional gene boundaries or haplotype blocks. The admixed LA population provides an exciting opportunity to identify new CRC genes that are more tractable to detection in LA, or have been missed by chance in European studies. We shall undertake a combined GWAS and admixture mapping study for CRC predisposition genes in 6,000 LA cases and 6,000 controls. We shall test the disease-associated variants in 3,500 cases and 3,500 controls from Europe. We aim primarily to detect SNPs with effects in both LA and Europe, but also SNPs with effects specific to LA. Eventually, we aim to develop a polymorphism panel for predicting the risk of CRC in the general population, so that those at increased risk can be offered effective measures to prevent cancer. CRC is increasing in frequency in LA and prognosis is poorer than in Europe. We shall use our project as a focus for education about CRC, especially in LA. The study will also provide training for young LA researchers. Our work will provide a direct benefit to medical science and the populations of LA and Europe.

Keywords: colorectal cancer genetics inherited predisposition common polymorphisms high-throughput genotyping targeting screening cancer education training in laboratory gneetics
Pan-European network for the study and clinical management of drug resistant tuberculosis (TB PAN-NET)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Italy,United Kingdom,Germany,Italy,Switzerland,Sweden,Denmark,Croatia,Estonia,Lithuania,Norway,Slovenia,Belgium,Romania,France,Finland,Belgium,Poland,Latvia,United States,Germany,Romania
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-01-01
End date: 2014-06-30
Duration (months): 66.0
Total project cost (EUR): 14115409.8
EU funding (EUR): 10998270.0
Participants: 32
Project status: CLOSED

This proposal will establish an integrated and synergistic network to address the challenge of multiple drug resistant tuberculosis (MDR-TB) facing the EU. The objective will be attained through the establishment of a European consortium of expert partners with extensive experience in the conduct of basic and clinical research relating to MDR-TB, TB control and epidemiology. This Consortium will achieve this by: • Conducting an extensive and focused programme of basic/clinical research to improve the diagnosis and management of MDR-TB • Develop a broad training curriculum leading to the creation of a new generation of scientists and clinicians expert in the management of drug resistant TB • Create field sites across the EU with the capacity for evaluating new diagnostic systems and novel drug therapies on behalf of European industry and government • Establish a unified and robust quality assurance mechanism for the accurate and rapid diagnosis of drug resistance and develop appropriate safety standard for European health care workers • Improving our understanding of the transmission of MDR-TB at the molecular level and host-related risk factors for its development, • The Consortium will disseminate its findings and analyses widely to the benefit of specialists, general health care staff, EU governments, NGOs and health policy makers. This will provide researchers and clinicians with appropriate knowledge and improved tools to fight MDR-TB, and assist European industry in the development of new diagnostics and treatments. Consortium outputs will assist governments in the development and implementation of appropriate health and social policies to limit and control the spread of MDR-TB within the member states of the EU. Internationally, these objectives will assist countries bordering the EU and international agencies such as the WHO and ECDC in reducing the impact of drug resistance.

Keywords: multi drug-resistant tuberculosis,extensively drug-resistant tuberculosis,molecular diagnosis,markers of resistance
No Pain during infancy by adapting off-patent medicines (NEOOPIOID)

Framework: FP7 — Cooperation
Programme: Health
Destination: Other Actions across the Health Theme
Action type: Collaborative project
Countries involved: Sweden,Sweden,Sweden,Sweden,Netherlands,Finland,United Kingdom,France,Belgium,Germany,United Kingdom,Belgium
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2008-10-01
End date: 2013-09-30
Duration (months): 60.0
Total project cost (EUR): 2881489.14
EU funding (EUR): 2299164.0
Participants: 13
Project status: CLOSED

Preterm and newborn infant may suffer from pain in the same way as adults. They are even more sensitive to pain due to immaturity of endogenous modulation. Thus, they should have the same human right to be alleviated from pain. The overall aim of this project is to assess effects and safety of opioid treatment in very preterm up to full term newborn infants in relation to pharmacokinetics predisposition. Furthermore, a major goal is to develop a PUMA for safe administration of opioid analgesic treatment in newborn infant. Both morphine and fentanyl are off-labelled (EMEA) drugs. Several studies have shown that opioid treatment in newborn reduce pain and stress responses. However, these drugs also have side-effects related to plasma concentrations of the drugs and their metabolites. The new approach in the current project is to obtain a more personalized drug therapy to the newborn infant, and to consider individual differences in pharmacokinetics, as well as gender effects. We will perform a multinational European survey of practices regarding sedation and analgesia in neonatal units. Clinical multicenter trial evaluating safety aspects of morphine and fentanyl will be performed. The responses (evaluated with validated pain scales) will be related to pharmacokinetics predisposition. A ”child friendly” formulation adapted for use in neonates will be developed by the SME partner in the NeoOpioid project. The results will be disseminated by scientific and popular articles, the web, videos and special pain courses for physicians and nurses etc. The NeoOpioid project will lead to a considerable improvement of the strategy to alleviate newborn pain.

Keywords: newborn,preterm,pain,analgesia morpjine,pharmacokinetics
Towards a common e-Science infrastrcucture for the European and Asian Grids (EUASIAGRID)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to policy development and Programme implementation
Action type: Coordination and support actions
Countries involved: Italy,Czechia,United Kingdom,France,Philippines,Australia,Taiwan, Province of China,Indonesia,Thailand,Malaysia,Singapore,Viet Nam
Call:  (FP7-INFRASTRUCTURES-2007-2, 2007)
Start date: 2008-04-01
End date: 2010-06-30
Duration (months): 27.0
Total project cost (EUR): 1315025.0
EU funding (EUR): 920000.0
Participants: 17
Project status: CLOSED

The EUAsiaGrid proposal contributes to the aims of the EU Research Infrastructures FP7 Programme by “promoting international interoperation between similar infrastructures with the aim of reinforcing the global relevance and impact of European e-Infrastructures”. The project’s main goal will be to pave the way towards an Asian e-Science Grid Infrastructure, in synergy with the other European Grid initiatives in Asia, namely EGEE-III via its Asia Federation, and both the EUChinaGRID and EU-IndiaGRID projects and their eventual follow on efforts. Taking advantage of the existing global Grid technologies, with the specific emphasis on the European experience with the gLite middleware and applications running on top of it, the project plans to encourage federating approaches across scientific disciplines and communities. EUAsiaGrid will act as a support action, aiming to define and implement a policy to promote the gLite middleware developed within the EU EGEE project across Asian countries. Its main actions will be to spread dissemination, provide training, support scientific applications and monitor the results.

Keywords: grid,e-science,egee,training,dissemination,grid applications,e-infrastructure use
A Pan-European Species-directories Infrastructure (PESI)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to policy development and Programme implementation
Action type: Coordination and support actions
Countries involved: Netherlands,Denmark,Türkiye,United Kingdom,Germany,Belgium,France,United Kingdom,Ireland,Finland,Italy,Spain,Slovakia,Greece,Netherlands,Lithuania,Sweden,Norway,Poland,Georgia,Spain,Slovenia,Bulgaria,Latvia,Israel,Poland,Ukraine,United Kingdom,France,Ireland,Italy,Switzerland,Romania,Russian Federation
Call:  (FP7-INFRASTRUCTURES-2007-2, 2007)
Start date: 2008-05-01
End date: 2011-04-30
Duration (months): 36.0
Total project cost (EUR): 4057628.0
EU funding (EUR): 2640000.0
Participants: 41
Project status: CLOSED

PESI provides standardised and authoritative taxonomic information by integrating and securing Europe’s taxonomically authoritative species name registers and nomenclators (name databases) that underpin the management of biodiversity in Europe. PESI defines and coordinates strategies to enhance the quality and reliability of European biodiversity information by integrating the infrastructural components of four major community networks on taxonomic indexing into a joint work programme. This will result in functional knowledge networks of taxonomic experts and regional focal points, which will collaborate on the establishment of standardised and authoritative taxonomic (meta-) data. In addition PESI will coordinate the integration and synchronisation of the European taxonomic information systems into a joint e-infrastructure and the set up of a common user-interface disseminating the pan-European checklists and associated user-services results The organisation of national and regional focal point networks as projected not only assures the efficient access to local expertise, but is also important for the synergistic promotion of taxonomic standards throughout Europe, for instance to liaison with national governmental bodies on the implementation of European biodiversity legislations. In addition PESI will start with the geographic expansion of the European expertise networks to eventually cover the entire Palaearctic biogeographic region. PESI supports international efforts on the development of a 'Global Names Architecture' by building a common intelligent name-matching device in consultation with the principal initiatives (GBIF, TDWG, EoL, SpeciesBase). PESI contributes the development of a unified cross-reference system and provides of high quality taxonomic standards. PESI will further involve the Europe-based nomenclatural services and link the planned joint European taxonomic e-infrastructures middle-layer to the global e-gateway.

Keywords: biodiversity informatics,biodiversity information standards,e-taxonomy,taxonomic standards,e-science,national focal points,nomenclator,fauna europaea,erms,euro+med plantbase,edit,marbef
Advancing ICT for DRM in Africa (AÏDA)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: ICT for mobility, environmental sustainability and energy efficiency
Action type: Coordination and support actions
Countries involved: Belgium,Tanzania, United Republic of,South Africa,Germany,Nigeria,Mali,Netherlands,France,Luxembourg,Switzerland
Call:  (FP7-ICT-2007-2, 2007)
Start date: 2008-06-01
End date: 2010-05-31
Duration (months): 24.0
Total project cost (EUR): 1267504.0
EU funding (EUR): 869000.0
Participants: 11
Project status: CLOSED

The AÏDA project aims at acquiring and sharing knowledge about affordable ICT (Information and Communication Technologies) solutions in Africa with the ambition to reduce the risk of natural disasters and to improve the capacity to respond to disasters. Many Developing Countries in Africa are exposed to serious natural disaster risks and their need for an adequate ICT infrastructure supporting DRM is high. Unfortunately, access to ICT knowledge and affordable ICT systems is often lacking. The AÏDA project will 1. assess the natural hazards, the vulnerability of the communities and the disaster risks in Africa; and 2. assess the role of ICT based systems in each hazard category; and 3. explore the ICT trends and needs for the future; and 4. test the usefulness of GEONETCast as an alert system; and 5. share this information with all DRM stakeholders in Africa (by workshops and other); and 6. prepare 3 showcases of operational African DRM systems for demo on these workshops; and 7. promote and support the take-up of this technology for use in other disasters; and 8. liaise with any new project in DRM with a significant involvement of African partners. AÏDA will test whether the existing GEONETCast infrastructure can be reused as a component of an alert or emergency system. AÏDA sets up a testcase in South-Africa where the Forest Fire Association in Nelspruit, South-Africa will use the wildfire-alarms from CSIR within their operational activities to fight wildfires. If successful, many DRM systems can benefit from this technology. The project is envisioned to have a big impact with a limited budget, by close cooperation with the AARSE and EUMETSAT conferences and within the UNeDRA network. This effort will support authorities in Developing Countries in setting up their National Disaster Action Plans (as required by the Hyogo agreements) by offering knowledge about working ICT solutions and help them to better manage their disaster risks.

Keywords: africa,disaster,hazards,vulnerability,risk drm (disaster risk management),early warning system,alert systems,emergency systems,ict (information and communication technology).
Control for coordination of distributed systems (CON4COORD)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Components, systems, engineering
Action type: Collaborative project
Countries involved: Netherlands,Netherlands,Netherlands,Cyprus,Belgium,Portugal,Greece,Italy,Belgium,Netherlands
Call:  (FP7-ICT-2007-2, 2007)
Start date: 2008-05-01
End date: 2011-08-31
Duration (months): 40.0
Total project cost (EUR): 3994585.0
EU funding (EUR): 2900000.0
Participants: 13
Project status: CLOSED

Control for coordination of distributed systems is motivated by the case studies of control for underwater vehicles, for aerial vehicles, for a road control and communication network, for automated guided vehicles, and for complex machines. The research thrust is in control design and control synthesis. In particular,control synthesis of a global coordinator of a distributed system, in communication for control, in informatics for control, and in tools for control design. Control design for the case studies based on the research thrust will form the main effort of the project and will be disseminated to the user partners. The contribution to the European Commission Work Program are in control of large-scale complex distributed systems (ICT-2007.3.7.(c)). The expected impacts are in: (1) enabling low cost monitoring for the environment and natural resources by underwater and aerial vehicles, (2) new services and applications for new markets in particular for automated guided vehicles at container terminals, control and communication networks on motorway networks; and (3) improved performance of distributed systems for control and communication on motorway networks, of complex machines, and of underwater and aerial vehicles. The consortium consists of five user partners and eight academic partners which combined have a very wide and very deep expertise in the many topics required for the proposed project.

Keywords: control,coordination,distributed systems,hybrid systems.
Nano Data Centers (NANODATACENTERS)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Pervasive and Trustworthy network and service infrastructures
Action type: Collaborative project
Countries involved: France,Spain,Germany,France,Greece,Switzerland,France,Australia,Israel
Call:  (FP7-ICT-2007-2, 2007)
Start date: 2008-05-01
End date: 2011-04-30
Duration (months): 36.0
Total project cost (EUR): 4903851.0
EU funding (EUR): 3010000.0
Participants: 10
Project status: CLOSED

The project proposes a radical solution to data hosting and delivery for the Internet of the future. The current data delivery architecture is “network centric”, with content stored in data centers connected directly to Internet backbones. This approach has multiple drawbacks among which complexity of deploying data centers, power consumption, and lack of scalability are the most critical. The ECHOS project takes a totally innovative and orthogonal approach to traditional data centers, through what we call “nano” data centers, which are deployed in boxes at the edge of the network (i.e. in home gateways, set-top-boxes, etc.) and accessed using a new peer-to-peer communication infrastructure. This disruptive evolution solves most of the inconveniences of current data center based solutions, and allows for the deployment of next generation interactive applications. However, this creates a number of challenges as data has to be accessed and assembled dynamically “on-demand”, in real-time. ECHOS will design and develop the nano-data center communication architecture with security and incentive mechanisms. We will demonstrate that ECHOS is a cheap and scalable alternative to the current data hosting and delivery model. The full ECHOS architecture will be implemented (i.e. an ECHOS box will be fully specified and implemented). Virtualization will be used to partition and manage box resources efficiently. Two interactive applications – multiplayer games and VoD – will be designed as a proof of concept. A large scale testbed will be deployed to evaluate the benefits and performance of ECHOS. We will contribute the ECHOS architecture to the relevant standardization bodies and to discussion groups on the design of the Internet of the Future. The project is in line with the Strategic Research Agenda (SRA) of the NEM initiative. The project is expected to lead to the commercialization of the ECHOS box. This will result in a competitive advantage for European industry and SMEs.

Keywords: future internet,data hosting and delivery,managed peer-to-peer (p2p),broadband access,tripleplay,video-on-demand (vod),distributed content management,multi-player games
Hierarchical and Distributed Model Predictive Control of Large-Scale Systems (HD-MPC)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Components, systems, engineering
Action type: Collaborative project
Countries involved: Netherlands,France,Belgium,Italy,Germany,Spain,Colombia,France,Spain
Call:  (FP7-ICT-2007-2, 2007)
Start date: 2008-09-01
End date: 2011-08-31
Duration (months): 40.0
Total project cost (EUR): 2768861.0
EU funding (EUR): 2000000.0
Participants: 9
Project status: CLOSED

Manufacturing systems, power networks, transportation systems, road traffic networks, process plants, and other large-scale networked systems are often composed of multiple subsystems, with many embedded sensors and actuators, and characterised by complex dynamics and mutual influences such that local control decisions have long-range effects throughout the system. This results in a huge number of problems that must be tackled for the design of an overall control system in order to achieve a safe, efficient, and robust operation. Otherwise, serious disasters and malfunctions could occur (such as the breakdown of the power grid in North America and in Italy in 2003). To deal with these problems and to cope with the complexity of the control task, we propose to use a hierarchical control set-up in which the control tasks are distributed over time and space. In such a set-up, systems of supervisory and strategic functionality reside at higher levels, while at lower levels the single units, or local agents, must guarantee specific operational objectives. At any level, the local agents must negotiate their outcomes and requirements with lower and higher levels. We will develop methods for designing controllers for complex large-scale systems based on such a hierarchical control framework. In particular, we propose to use Model Predictive Control (MPC), which has already proven its usefulness for control of small-scale systems, but which cannot yet be applied to large-scale systems due to computational, coordination, and communication problems. We will solve these issues and develop new MPC methods for large-scale networked systems, both under normal operation conditions, and in the presence of uncertainty and disturbances. We will perform both fundamental research and more application-oriented research in which the methods developed in the project are applied to case studies and benchmarks provided by the partners from industry.

Keywords: predictive control,distributed control,large-scale systems,control of networked systems