Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
How epigenetic reprogramming modulates 3D chromatin organization in totipotent embryos (Epigenome_embryo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2024-01-05
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: CLOSED

One of the most intriguing questions in biology is how a single cell (zygote) is generated that has the potential to give rise to all cell types of an organism, known as totipotency. The overall purpose of this project is to gain mechanistic insights into the establishment of the totipotent state, in terms of 3D chromatin organization and zygotic genome activation (ZGA), summarized in two key aims: i)To test whether and how epigenetic reprogramming modulates the 3D chromatin structure in zygotes: The generation of a zygote is accompanied by Tet3-dependent active DNA demethylation of the paternal genome and asymmetry in histone modifications between the parental genomes. Whether this alters chromatin organization and promotes transcription is poorly understood. To test this, I will perturb Tet3 activity and perform single nucleus Hi-C (snHi-C) of zygotes to determine changes in genome architecture. In addition, I will study the effect of the absence of Kdm4a on the different histone marks and the consequent potential effect on chromatin architecture. This work will provide the first insights into how epigenetic reprogramming alters chromatin organization. ii) To study the mechanism of ZGA: The activation of embryonic transcription is crucial for the development of an organism. However, the essential activators of ZGA in mammals remain largely unidentified. Based on work in Drosophila, a leading hypothesis is that ZGA is triggered by pioneer transcription factors. To identify these, I will participate in a targeted knockdown screen in embryos to identify factors required for ZGA. I will focus on one potential candidate and generate transgenic mouse strains to study its function in early embryos. This high-risk high-gain aim has the potential to identify novel regulators of the mammalian ZGA.

Keywords: dna demethylation,histone modification,chromatin architecture,totipotency,zygotic genome activation,zygotic reprogramming
FArming Tools for external nutrient Inputs and water MAnagement (FATIMA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Italy,Germany,Spain,Italy,Spain,Greece,Türkiye,Greece,Türkiye,Bulgaria,Greece,Latvia,France,Czechia,Czechia,Netherlands,Portugal
Call: External nutrient inputs (H2020-SFS-2014-2, 2014)
Start date: 2015-03-01
End date: 2018-02-28
Duration (months): 36.0
Total project cost (EUR): 7966697.0
EU funding (EUR): 7966697.0
Participants: 22
Project status: CLOSED

FATIMA addresses effective and efficient monitoring and management of agricultural resources to achieve optimum crop yield and quality in a sustainable environment. It covers both ends of the scale relevant for food production, viz., precision farming and the perspective of a sustainable agriculture in the context of integrated agri-environment management. It aims at developing innovative and new farm capacities that help the intensive farm sector optimize their external input (nutrients, water) management and use, with the vision of bridging sustainable crop production with fair economic competitiveness. Our comprehensive strategy covers five interconnected levels: a modular technology package (based on the integration of Earth observation and wireless sensor networks into a webGIS), a field work package (exploring options of improving soil and input management), a toolset for multi-actor participatory processes, an integrated multi-scale economic analysis framework, and an umbrella policy analysis set based on indicator-, accounting- and footprint approach. FATIMA addresses and works with user communities (farmers, managers, decision makers in the farm and agribusiness sector) at scales ranging from farm, over irrigation scheme or aquifer, to river-basins. It will provide them with maps of fertilizer and water requirements (to feed into precision farming machinery), crop water consumption and a range of further products for sustainable cropping management supported with innovative water-energy footprint frameworks. All information will be integrated in leading-edge participatory spatial online decision-support systems. The innovative FATIMA service concept considers the economic, environmental, technical, social, and political dimensions in an integrated way. FATIMA will be implemented and demonstrated in 8 pilot areas representative of key European intensive crop production systems in Spain, Italy, Greece, Netherlands, Czech Republic, Austria, France, Turkey.

Keywords: farm advisory services,nutrient efficiency,irrigation management,agri environmental indicators,water and energy footprint,participatory multi actor
ModulAR Plug-in Mechatronic DeviceS for vibration suppression in manufacturing equipment (MARS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In today's competitive Manufacturing Equipment market, the requirement for products combining high performances, low Life Cycle Costs (LCC) and environmental sustainability is a driven criterion. Within this sector, CeSI-Centro Studi Industriali has assumed a key role at national and international level in the development of innovative products combining high performances, flexibility and quality. Strongly committed to innovation CeSI has built a solid network with European Universities and Research Organizations to provide its customers with forefront solutions to improve machining performances. In this framework CeSI is working to develop a novel solution to minimize vibrations, an issue that can seriously compromise the quality of the workpiece, currently addressed only with costly, custom-made solutions. In MARS project an innovative, flexible, modular, plug-and-play mechatronic device based on piezoelectric stack actuators is proposed: AViA (Active Vibration Absorber), able to reduce vibration up to 70% in the frequency range of 50-500Hz, and to: •Increase productivity by up to 20% (machine can work with more demanding parameters, reducing machining steps and cycle time) •Reduce LCC by up to 15% •Improve part finishing •Double tool lifetime, reducing its wear •Reduce scraps, and therefore environmental impact AViA will be sold as add-on kit, composed by: •Mechanical HW to be installed on the Machine Tool •Electronic HW and control SW •Application Program Interface to support the user-friendly configuration of the device Thanks to AViA, CeSI expects to increase its turnover up to +150% in 3 years after the beginning of commercialisation. The main objectives of MARS is to confirm this forecast, and to evaluate the technical feasibility of developing scalable modules, able to meet a wide range of requirements, investigating at the same time the market, examining the business opportunity and proposing a suitable commercialisation plan.

Keywords: mechatronic system,vibration control
Scalable graphene-gated transistors (GR-GATE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Greece
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-03-01
End date: 2019-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

'The GR-GATE project proposes a novel negative quantum capacitance field effect transistor (NQCFET) with steep subthreshold characteristics which enables operation at low power supply voltages (Vdd). The technology can be combined with state of the art Si device architectures such as FDSOI or more mature steep slope switches such as the tunneling field effect transistor (TFET) functioning as technology booster to improve low power /high performance operation characteristics of transistors. The later can have an impact on energy efficient nanoelectronics. NQCFET has competitive advantages against rival emerging steep slope switch technologies and complements rather than competes with mainstream Si devices, therefore showing a high potential for non-disruptive innovation and a prospect for fast and smooth entry to large volume production. The GR-GATE project will produce prototype transistor arrays at TRL 4 to show that the NQCFET technology is scalable to larger area wafers with acceptable device yield having reduced gate lengths and lower gate dielectric thickness in compliance with scaling trends and technological requirements as adopted by the industry. This will demonstrate that the technology has a commercial value calling for IP protection through an international patent filing. In addition, technology valorisation is planned in order to assess the manufacturability and viability of the NQCFET technology and identify further advanced development steps that need to be taken in order to bring the technology to maturity (TRL 8-9). It is expected that large European technology development laboratories will have a crucial role in validating the technology but also promoting it to their industrial affiliates targeting a licence agreement with key chip manufacturers to enable volume production. '

Keywords: steep slope switching,low subthreshold slope,low power,energy efficient nanoelectronics,negative quantum capacitance field effect transistors,graphene based nanolectronic devices,the internet o
Enhance Aircraft Performance and Optimisation through utilisation of Artificial Intelligence (PERF-AI)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France
Call: Application of machine learning techniques to enableenhance aircraft performances database and facilitate mission optimization objectives (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 705125.0
EU funding (EUR): 568550.0
Participants: 2
Project status: CLOSED

PERF-AI will apply Machine Learning techniques on flight data (parametric & non-parametric approaches) to accurately measure actual aircraft performance throughout its lifecycle. Within current airline operations, both at flight preparation (on-ground) & at flight management (in-air) levels, the trajectory is first planned, then managed by the Flight Management System (FMS) using a single manufacturer’s performance model that is the same for every aircraft of the same type, & also on weather forecast that is computed long before the flight. It induces a lack of accuracy during the planning phase with a flight route pre-established at specific altitudes & speeds to optimize fuel burn, from take-off to landing using aircraft performances that are not those of the real aircraft. Also, the actual flight will usually shift from the original plan because of Air Traffic Control (ATC) constraints, adverse weather, wind changes & tactical re-routing, without possibility for the flight crew, either using the FMS or through connected services to tactically recompute the trajectory in order to continuously optimize the flight path. This is in particular due to the limitations of the performance databases that the current systems are using. Hence, PERF-AI is focusing on identifying adequate machine learning algorithms, testing their accuracy & capability to perform flight data statistical analysis & developing mathematical models to optimize real flight trajectories with respect to the actual aircraft performance, thus, minimizing fuel consumption throughout the flight. The consortium consists of Safety-Line (FR) & INRIA (FR), having full expertise at Aircraft Performance & Data Science, hence, able to fully propose, test & validate different statistical models that will allow to accurately solve some optimization challenges & implement them in an operational environment. PERF-AI total grant request to the CSJU is 568 550€ with total project duration of 24 months.

Keywords: machine learning algorithms,aircraft performance and optimisation,artificial intelligence,flight data statistical analysis
ID.Conference – New event management experience for regulated conferences (ID.Conference)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Slovenia
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

IDC is specialized in identification and RFID solutions, developed and tested in real environment a working prototype of event management platform ID.Conference, with yet unseen attendee tracking and business analytics capacities. In addition, we will, through introducing novel market place module, profoundly change the concept of the event management organization. With ID.Conference we will tap into the event management software market, a business opportunity where total addressable marekt (TAM) estimated at 43 Bn in 2020 and growing with CAGR 10.3% between 2017-2020. Comprehensive technology, ID.Conference, will respond to yet unmet challenge of event planning organizations to automate and control a complete event organization process by using a single ICT solution, driving down their operational costs, ensuring maximum engagement of the participants and thus demonstrate high return on investment to the event stakeholders. Market maturation and launching ID.Conference to the global market are main overall objectives of the proposed project which will result in high growth of our company.

Keywords: event management,rfid uhf technology,advanced bi,decentralization,concept,new walue chains
Development of a prototype clinical photoacoustic scanner for use in plastic and reconstructive surgery (PHOTOPARS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-02-01
End date: 2021-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Plastic and reconstructive surgical procedures provide a means of reconstructing tissues following damage due to cancer, trauma, burns and infections. An important example is flap surgery which involves transferring skin and the underlying tissues from one part of the body to another; for example, in the DIEP flap breast reconstruction procedure, skin and tissue from the abdomen is removed and implanted in the breast. For a successful repair, it is essential that the transplanted tissue develops an adequate blood supply. Failure to do so results in tissue death (necrosis) which can lead to complications such as infection, delayed wound healing and disfigurement due to scarring with attendant psychological trauma. This proposal seeks to address this by developing and constructing a prototype clinical imaging instrument based on a novel photoacoustic technology which can provide highly detailed three-dimensional maps of blood vessels. This technology offers the prospect of reducing the number of complications and the need for repeat procedures with consequent benefits in terms of reduced patient trauma and lower healthcare provider costs.

Keywords: photoacoustic,medical imaging,plastic and reconstructive surgery
Addressing vaccine hesitancy in Europe (VAX-TRUST)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Belgium,Poland,Finland,Finland,Czechia,United Kingdom,Portugal
Call: Addressing low vaccine uptake (H2020-SC1-2020-Single-Stage-RTD, 2020)
Start date: 2021-03-01
End date: 2024-02-29
Duration (months): 36.0
Total project cost (EUR): 2971675.0
EU funding (EUR): 2971675.0
Participants: 10
Project status: SIGNED

Distrust of expertise represents a great challenge for modern societies. In particular, it creates difficulties for healthcare professionals, given that citizens are arriving at the consultancy room with ready-made diagnoses, internet misinformation and contested attitudes. Vaccine hesitancy epitomizes this contestation: some parents refuse to vaccinate their children which leads to low vaccine coverage and risks of disease outbreaks. VAX-TRUST will contribute to increasing vaccine uptake in Finland, Belgium, Poland, Czech Republic, Italy, Portugal, and the UK and Europe as a whole by: 1) equipping healthcare professionals with tailored up-to-date knowledge on vaccine hesitancy in their specific local region and nation in international perspective; this knowledge will be obtained through (a) critical review of previous research on vaccine hesitancy, (b) a quantitative study using existing Eurobarometer 91.2 data (n=27,524 in 28 countries), (c) a quantitative and qualitative media analysis during 2019-2021 and (d) qualitative observations and interviews with healthcare professionals and parents (n=60 per region) at local healthcare centres in specific Target Regions; 2) giving healthcare professionals tools, support and peer support to deal with vaccine hesitancy, taking into account that some professionals may themselves be vaccine hesitant. This will involve specific interventions tailored for the Target Regions and include 50-100 individuals. These interventions will be evaluated for usability and transferability; 3) distributing the intervention tools to future healthcare professionals in order to strengthen their knowledge about vaccine hesitancy and facilitate support to meet with vaccine hesitancy in their future career; exploitation events will aim at 50-100 medical and nursing students in each Target Region; 4) identifying and communicating targeted recommendations to Target Regions, the seven countries and European area based on the project activities.

Keywords: vaccine hesitancy,healthcare professionals,intervention,parents,distrust of expertise
Training on Laser Fabrication and Ion Implantation of Defects as Quantum Emitters (LasIonDef)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Italy,Italy,Italy,Belgium,Poland,France,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 3281943.0
EU funding (EUR): 3281943.0
Participants: 8
Project status: SIGNED

LasIonDef will establish an effective and innovative network delivering high level training in integrated quantum photonic and microfluidics platforms and helping to fulfil Europe’s necessity for expertise in applied quantum technologies. The project unites outstanding European academic and industry researchers with complementary theoretical and experimental background to develop tomorrow’s quantum technologies. Photonic quantum devices based on solid state quantum emitters represent one of the most promising approaches to realize quantum technologies such as quantum sensing, quantum communication and quantum computing. Quantum technologies are expected to mimic trends seen in semiconductor microelectronics, whereby sophisticated networks are composed of simpler building blocks, from a favoured group of advanced materials. LasIonDef will provide highly qualified young professionals skilled training on the design, theory, fabrication, characterisation, and integration of quantum devices in emerging quantum material platforms such as diamond, GaN, and hBN. To the industrial partners, the project will offer young and brilliant researchers, with relevant skills to prosper in an industrial environment, while delivering cutting-edge quantum photonic devices. LasIonDef will contribute to the teaching and dissemination of quantum physics and quantum technologies by producing open access educational material. LasIonDef will train 13 ESRs in the highly interdisciplinary field of quantum technologies, provide 3 years of training within the facilities of our research centers and industrial partners. In addition, LasIonDef will further strengthen Europe’s world leading position in research and development of quantum technologies.

Keywords: laser microfabrication,ion implanation,femtosecond laser,diamond,sensor