Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Roads to memory: Studying the regulation of lymphocyte stemness by fate mapping of single T and NK cells (SCIMAP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 1499236.0
EU funding (EUR): 1499236.0
Participants: 1
Project status: SIGNED

Almost two decades ago it was first proposed that immunological memory may depend on stem cell-like mechanisms, enabling individual antigen-specific T and B cells to generate progeny that contains short-lived effectors as well as long-lived memory cells. To test this capacity, I have in the past developed a stringent set of single cell-based approaches, which allowed me to show that single CD8+ and CD4+ T central memory cells harbour the capacity to self-renew and generate a diverse offspring of effector cells, but also, show immense variation in executing these essential functions upon activation. Thus, even physiological immune responses to infection appear not to harness the full protective potential available in every antigen-specific lymphocyte. To better understand the regulatory principles underlying this single-cell derived variation, in the context of classical T-cell memory, T-cell exhaustion and memory-like NK cell responses, I developed novel fate mapping technologies such as ‘single-cell colour barcoding’ and ‘single-cell RNA barcoding’. I will now integrate these approaches with single-cell RNA sequencing, genetic reporter systems and continuous live-cell imaging, to answer three fundamental questions in immunobiology: 1) Do exhausted T-cell responses to chronic infection and adaptive-like immune responses of NK cells also rely on the stem cell-like potential of individual cells? 2) Do single-cell-derived T and NK cell families enter the memory or memory-like exhausted compartment on a direct road or through de-differentiation, after passing through an early effector state? And 3) how is the development of these T and NK cell families influenced by their founding members’ fundamental cellular properties, such as asymmetric cell-division, quorum sensing and cell-cycle speed? Answering these questions will help to identify new molecular targets and therapeutic strategies to enhance or reinvigorate protective immunity against infection or malignancy.

Keywords: t cell memory,nk cell memory,t cell exhaustion,stemness,single cell fate mapping,single cell rna sequencing,rna velocity,lcmv,mcmv
Integrated Arctic observation system (INTAROS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Developing comprehensive and sustained global environmental observation and information systems
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Ireland,Germany,Germany,Germany,Spain,Italy,Belgium,Norway,Norway,Finland,Poland,Sweden,Norway,Sweden,Norway,Poland,Poland,China,Korea, Republic of,Russian Federation,France,France,United States,Portugal,Denmark,Denmark,United Kingdom,United Kingdom,United Kingdom,Canada,Denmark,Greenland,Japan
Call: An integrated Arctic observation system (H2020-BG-2016-1, 2016)
Start date: 2016-12-01
End date: 2022-02-28
Duration (months): 63.0
Total project cost (EUR): 15490066.78
EU funding (EUR): 15490066.78
Participants: 51
Project status: CLOSED

The overall objective of INTAROS is to develop an integrated Arctic Observation System (iAOS) by extending, improving and unifying existing systems in the different regions of the Arctic. INTAROS will have a strong multidisciplinary focus, with tools for integration of data from atmosphere, ocean, cryosphere and terrestrial sciences, provided by institutions in Europe, North America and Asia. Satellite earth observation data plays an increasingly important role in such observing systems, because the amount of EO data for observing the global climate and environment grows year by year. In situ observing systems are much more limited due to logistical constraints and cost limitations. The sparseness of in situ data is therefore the largest gap in the overall observing system. INTAROS will assess strengths and weaknesses of existing observing systems and contribute with innovative solutions to fill some of the critical gaps in the in situ observing network. INTAROS will develop a platform, iAOS, to search for and access data from distributed databases. The evolution into a sustainable Arctic observing system requires coordination, mobilization and cooperation between the existing European and international infrastructures (in-situ and remote including space-based), the modeling communities and relevant stakeholder groups. INTAROS will include development of community-based observing systems, where local knowledge is merged with scientific data. An integrated Arctic Observation System will enable better-informed decisions and better-documented processes within key sectors (e.g. local communities, shipping, tourism, fisheries), in order to strengthen the societal and economic role of the Arctic region and support the EU strategy for the Arctic and related maritime and environmental policies.

Keywords: observation system,in situ,arctic,integrated,ocean,atmosphere,terrestrial,ecosystems,communities
Optimizing Industrial Applications for Heterogeneous HPC systems (OPTIMA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Innovation actions
Partnership: EuroHPC (Art-187)
Countries involved: Germany,Germany,Spain,Italy,Italy,Greece,Switzerland,Greece,Greece,Netherlands
Call: Industrial software codes for extreme scale computing environments and applications (H2020-JTI-EuroHPC-2019-1, 2019)
Start date: 2021-03-01
End date: 2023-11-30
Duration (months): 33.0
Total project cost (EUR): 4138287.5
EU funding (EUR): 1742477.5
Participants: 11
Project status: SIGNED

In order to support the expanding demands for processing power from emerging HPC applications, within a pragmatic energy envelope, the future HPC systems will incorporate accelerators. One promising approach, towards this end, is the utilization of FPGAs; the main advantage of those devices is that, since they can be reconfigured at any time so as to implement tailor-made application accelerators, their energy efficiency and/or performance, in most of the cases, is much higher than that of CPUs and GPUs. OPTIMA is an SME-driven project aiming to port and optimize a number of industrial applications as well as a set of open-source libraries, utilized in at least 3 different application domains, to two novel FPGA-populated HPC systems, utilizing several innovative programming environments. It is expected that the applications and the libraries will be executed, in those heterogeneous HPC systems at significantly higher energy-efficiency as described by the Energy Delay Product metric (EDP); in particular, the EDP of the OPTIMA applications and libraries when executed on the targeted FPGA-based HPC systems, is expected to be more than 10x higher than that triggered by CPU-based systems and more than 3x higher than the GPU-based ones. The main outcomes of OPTIMA will be that: a) the participating SMEs will gain a significant advantage since they will be able to execute their applications much more efficiently than the competition, b) it will be further proved that Europe is at the forefront of developing efficient FPGA-populated HPC systems and application/libraries taking advantage of them, c) the open-source libraries as well as the open-source applications developed within OPTIMA will allow third parties to easily target FPGA-based HPC systems for their application developments, d) there will be an open-to-use HPC infrastructure supported by a specially formed sustainability body.

Keywords: heterogeneous hpc systems,fpgas,accelerators,industrial hpc applications,open source libraries
The potential of Sharing Resources for mitigating carbon emissions and other environmental impacts (ShaRe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2024-09-07
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Household sizes in countries of the European Union have been declining steadily, and this trend is set to continue in the future. This is likely to ‘slow down’ reductions of per capita carbon emissions because it reduces economies of scale within households. It is important to understand these ‘reduction offsets’ in order to design effective carbon reduction policies. This project will examine the role of declining household sizes for trends in per capita carbon emissions and other environmental impacts, using longitudinal and cross-sectional household expenditure datasets for EU countries, and input-output data on emissions and other environmental impacts. Qualitative expert interviews will be carried out to formulate policy recommendations, taking underlying sociological and demographic trends into account. This project therefore seeks to make an original empirical and theoretical contribution to understanding the ways in which consumption-based emissions and environmental impacts are embedded within broader socio-cultural trends. Its policy recommendations will help to design more effective carbon reduction policies. This fellowship will facilitate a unique two-way transfer of knowledge between the host, Dr Buchs, at the University of Leeds Sustainability Research Institute, and the ER, Dr Ivanova, from the Norwegian University of Technology and Science. Dr Ivanova, a trained economist, will contribute her skills in input-output carbon footprinting modelling and econometric analysis. She will gain new knowledge and skills in the sociological and mixed methods analysis of underlying trends of household emissions and environmental impacts, as advised by Dr Buchs who is an environmental social scientist. The fellowship will equip Dr Ivanova with new knowledge, research and project management skills, enabling her to establish herself as an internationally recognised academic in this field and a connector between research, policy and civil society.

Keywords: social embeddedness of carbon emission trajectories,sustainable consumption,changes in household size and formation,sharing economy,mixed methods research,mitigation potential
INTEGRATED EU STRATEGY, SERVICES AND INTERNATIONAL COORDINATION ACTIVITIES FOR THE PROMOTION OF COMPETITIVE AND SUSTAINABLE NANOFABRICATION INDUSTRY (SUSNANOFAB)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Coordination and support actions
Countries involved: Austria,Ireland,Italy,Spain,Spain,Italy,Belgium,Sweden,France,France,United States,Portugal
Call: Sustainable Nano-Fabrication (CSA) (H2020-NMBP-TO-IND-CSA-2019, 2019)
Start date: 2020-03-01
End date: 2023-02-28
Duration (months): 36.0
Total project cost (EUR): 2038978.75
EU funding (EUR): 1999918.75
Participants: 16
Project status: CLOSED

Nanofabrication has the potential to make a significant impact in a multitude of diverse areas and to tackle major socio-economic challenges for an ever improving yet affordable health care, higher standards of living and quality consumer goods, cleaner energy and transport. Given the above mentioned potential of nanofabrication, the present project SUSNANOFAB tackles all nanofabrication technological and non-technological issues of the nanofabrication value chain, facilitating interactions among stakeholders. The global target of SUSNANOFAB project is to put in place an integrated concerted action on nanofabrication sustainable in the long term. At strategic level the project will find a common strategy to enable all pre-competitive conditions for successful market uptake of nanofabricated products and solutions. This will be reached using a structured roadmapping methodology and involving external experts in Coordination Groups. At operational and end-users’ level, the project will provide affordable services and easy access point to infrastructures and knowledge to EU stakeholders, and in particular to SMEs. This will be reached using different integrated methodologies such as the organisation of a large set of training and brokerage workshops and services and the development of a Digital Platform, which will perform in an interoperable manner with ongoing platforms and initiatives (e.g. the European Network for Pilot Production Facilities and Innovation Hubs, the European Material Modelling Council etc.). To promote international cooperation SUSNANOFAB Consortium includes 3 US partners not requesting EU funding. To involve high number of key actors, the project has already achieved the support of several companies, research and education establishments, European Technology Platforms, clusters and industrial associations, national, regional and international nanofabrication related entities. 34 support letters were received and are included.

Keywords: nanofabrication,manufacturing upscale,roadmap,training,brokerage services,interoperable digital platform,network,international cooperation
Desing of a Virtual Blood Rheometer for Thrombotic Process Characterization (ViBRheo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

Early-stage diagnosis and continuous non-invasive monitoring of coagulopathies is a challenging problem that has been exacerbated by the COVID-19 pandemic. In this context, viscoelastic characterisation of the whole blood and plasma represents an excellent diagnosis approach, incorporating implicitly several molecular factors. However, a careful interpretation of coagulation abnormalities and adaptation of the techniques to the new disease is needed. ViBRheo aims to construct a novel computational multiscale framework able to detect alterations in blood rheology during clot formations. The framework will account for variations of viscometric properties at clinically-relevant conditions, whereas incorporating large memory effects related to coagulation kinetics from the microscales. Our goal is to translate research models into clinical applications. Thus, facilitating the virtual calibration and the design of microfluidic devices to extract microstructural features of blood undergoing clotting. Additionally, ViBRheo will potentially lead to the definition of mechanistic biomarkers for early detection and easier monitoring of acute coagulopathy on COVID-19 patients. ViBRheo will count on the support of an interdisciplinary team, with broad expertise on medicine, modelling, engineering, physics, and applied mathematics. Furthermore, it will promote theoretical/experimental exchange on hemorheological results. The development of a computational tool is in line with the 2030 UN Sustainable Development Goals. It facilitates early response to unprecedented diseases with broad applicability in coagulation disorders, beyond the current COVID19-related coagulopathies.

Keywords: multiscale modeling,thrombus formation,rheology,covid19,heterogeneous multiscale,blood,sdpd
Nationalist State Transformation and Conflict (NASTAC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-11-01
End date: 2024-10-31
Duration (months): 72.0
Total project cost (EUR): 2631556.0
EU funding (EUR): 2631556.0
Participants: 1
Project status: SIGNED

Scholars studying contemporary conflict and development have increasingly turned to the historical roots of state formation. Going beyond Tilly’s classical theory of state formation, the NASTAC project creates a new theory of nationalist state transformation that will be evaluated with historical maps and archival data extracted through machine learning. While much has been written about state formation and nationalism, there is currently no empirically verified theory that shows how nationalism transformed and keeps transforming state internal and external properties, and how post-nationalist mechanisms counteract this influence. Without such a framework it is difficult to know under what conditions partition or power sharing should be used to pacify conflict-ridden multi-ethnic states. The project contains four work packages (WPs). WP1 will investigate whether state penetration and the evolution of the size and shapes of states have interacted with warfare according to Tilly’s expectations. WP2 will develop our theory of nationalist state transformation showing how nationalism affected internal state reach and how it triggered external change, such as secession, unification and irredentism, and, in turn, how these processes interacted with, and modified, patterns of conflict. WP3 will apply the theory of nationalist state transformation to the post-1945 world and will analyze how it interacts with post-nationalist mechanisms, such as power sharing. WP4 will develop innovative methods that draw on recent advances in machine learning techniques, such as deep learning, in order to transform historical maps and documents into disaggregated and spatially explicit datasets with extensive historical scope. Led by Lars-Erik Cederman, the NASTAC project will be hosted by the International Conflict Research group at ETH Zürich, which has published extensively in top outlets and has ample experience in managing large research projects.

Keywords: state formation,nationalism,ethnicity,conflict,state size,empires,colonialism,borders,secession,partition,unification,irredentism,machine learning,neural networks
self-assembled/healable Hybrid inorganic/Organic Polymer Electrolytes for sustainable electrochemical energy Storage (HOPES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-21
End date: 2024-03-20
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

Threatened by climate change, mankind is facing increasing demands for energy (generation, conversion, and storage) solutions to meet societal needs in a globalized economy. Energy and cost-efficient sustainable batteries will be instrumental in reaching climate-neutral (EU) continent by 2050 and UN SDG N°7 objectives by storing intermittent energy resources and enabling a green transport revolution. To address these grand challenges, the project HOPES targets safer-by-design self-healing All-Solid-State Alkali Metal Batteries (ASSAMBs), thus implementing a paradigm shift going beyond the ubiquitous Lithium-ion Battery (LiB) technology. Taking Lithium Metal Batteries (LMBs) as a post-LiB blueprint for ASSAMBs, Solid-State Hybrid Electrolytes (SSHEs) will be developed through a circular chemistry approach to enable LMBs, facilitating their inception onto the market. Within HOPES, we will i) develop mechanically, thermally, electrochemically tough self-healable and recyclable SSHEs through the colloidal self-assembly of nanosized building blocks consisting of inorganic core and end-group (vitrimer functionality)-functionalized Li+ conducting polycarbonate shell: Hairy NanoParticles (HNPs), and ii) establish multi-scale structure/property correlations with advanced characterization techniques at HNP, SSHE, and LMB levels, including synchrotron-based in situ and operando characterizations on operating LMBs. Depolymerization of HNP’s organic shell will trigger the disassembly of SSHEs, thereby authorizing the recovery & reuse of inorganic NP cores and (bio-based/sourced) cyclocarbonate monomers, but also the recycling & reuse of (NMC811) cathode and Li° anode to secure critical/strategic minerals and metals in EU. In line with roadmaps of the FET-Flagship Battery 2030+ initiative & EBA250, HOPES will act as a springboard to realize ambitions and objectives of the EU Green Deal, thus contributing to position EU as a major research player and battery manufacturer by 2030.

Keywords: functional soft matter,colloidal self assembly,circular chemistry,all solid state alkali metal anode batteries,multiscale in situ and operando characterizations,ionic transport,nanoionics