Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SECRETED FACTORS IN CARDIAC REMODELING PROVOKE TUMORIGENESIS AND END ORGAN DAMAGE IN HEART FAILURE (SECRETE-HF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands,Netherlands
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-07-01
End date: 2025-03-31
Duration (months): 69.0
Total project cost (EUR): 1999861.0
EU funding (EUR): 432748.06
Participants: 2
Project status: SIGNED

The objective of SECRETE-HF is to demonstrate the effects of secreted factors from failing hearts to explain the etiology of multimorbidity in heart failure (HF). The project focuses on two co-morbid patterns: 1) the emerging susceptibility of HF patients for incident cancer, 2) the more established co-morbid conditions of renal, liver and pulmonary disease in HF. The rationale is: • HF treatment has improved, yet morbidity and mortality remain high, which can be attributed to co-morbid conditions rather than pump failure alone. • HF treatment is heart-oriented, neglecting the systemic effects that come with HF, and the associated morbidity and mortality. • Using innovative experimental approaches such as organ transplant models, target finding, and deep phenotyping of clinical databases I will dissect HF-derived effects on tumor growth and organ damage. OBJECTIVES 1. To establish the effects of HF, due to different etiologies, using the state-of-the-art heart transplantation murine model with (spontaneous) formation of colon and renal tumors, and phenotype tumor growth, as well as the main HF-affected organs: kidney, liver and lungs. 2. Identification of the cardiac secretome using unbiased approaches. 3. Integrate the results and identify overlapping and diverse factors from different HF forms, and their consequences for tumor growth and kidney/liver/lung remodeling. 4. Validate discoveries in human cohorts with data on incident HF, cancer and organ function. 5. Create clinical algorithms to detect, monitor and act on extra-cardiac disease. WORKPACKAGES WP 1: Create HF, murine heart transplantation models; phenotype tumor growth and organ involvement. WP 2: Explore the proteomic, metabolomic and extracellular vesicle profiles from HF subforms. WP 3: Validate secreted factors in vitro and in vivo. WP 4: Validate human relevance in large population-based cohorts with unique phenotyping. WP 5: Describe added value of novel markers and design clinical

Keywords: aetiology,diagnosis and treatment,epidemiology,cross disciplinary
First-of-its-kind, large-scale, lowest-cost, zero-waste biorefinery for the production of proteins for food and feed application from low cost sustainable feedstocks. (PLENITUDE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Innovation actions
Partnership: BBI (Art-187)
Countries involved: Italy,Belgium,Belgium,France,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Large-scale production of proteins for food and feed applications from alternative, sustainable sources (H2020-BBI-JTI-2018, 2018)
Start date: 2019-10-01
End date: 2025-12-31
Duration (months): 75.0
Total project cost (EUR): 29029301.68
EU funding (EUR): 16937253.61
Participants: 13
Project status: SIGNED

PLENITUDE will build a bio-based value chain based around a unique highly efficient zero-waste process that produces sustainable protein by integrating an aerobic fermentation plant with a conventional first generation biorefinery. PLENITUDE will increase the availability of sustainable, safe, food-grade protein by building and operating a large-scale, first-of-its-kind bio-based value chain producing food-grade protein sourced from sustainable sources such as wheat using an integrated biorefinery setup. PLENITUDE directly addresses the topic “BBI.2018.SO3.F2” through enabling food-grade mycoprotein production within an integrated bioethanol refinery. The output protein will contribute to meeting the rapidly growing global protein demand identified in the specific challenge of the topic. PLENITUDE will create initial output capacity of 16k tonnes per annum and based on the predicted outputs, the consortium aim to extend this capacity post project to produce a cumulative 1M tonnes of protein by 2030, which as a like for like replacement for meat from livestock equates to a reduction of >5M tonnes of carbon emissions. The consortium has a strong industrial base led by Alcogroup, coordinated by 3F BIO, and supported by partners covering the entire value chain for the creation of both new bio-based food products and new value chains across both B2B and B2C markets.

Keywords: mycoprotein,biorefinery,sustainability,zero waste
International leagues of art for creative people (MUNDOARTI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The cultural sector turnover was around 300 billion € (5.3%) and 6.3 million Europeans were working in this sector in 2014 (2.9%). Despite these figures representing a considerable volume, the cultural sector is still unprofessional and there is a high young unemployment. In response to the current problems that those in European society face, Mundoarti has designed an initiMundoArti is a global cultural company focused on improving the ways people develop, share and promote their creativity. Among its projects, it is worth highlighting the reinvention of the way in which people present themselves to cultural competitions, improving efficiency and transparency. This European project, International leagues of art for creative people" is an innovative type of professional competition that tries to evolve cultural contest into a more dynamic context. Our value proposition is to create a new way of competing, creating art leagues. This concept is based on the success of photography leagues as a union of the scores of several contests, but MundoArti applies new video game techniques, such as e-sports, to allow scalability and gamification. This new innovative technology will allow us to generate countless art leagues at different regional levels. Unlike our competitors, MundoArti algorithm is the only one available in the market that improves the selecting process to deliberate thousands of creative works in the most convenient, transparent and cost-effective way by using professional jury. That is key to the sustainability of competitions in the future. Within three years, our scope is to be the first platform to participate in cultural competitions and we will create different leagues at different levels (country, European and international levels) and for different artistic disciplines: photographers, writers, designers, musicians, filmmakers, etc. The ultimate goal in a post-Phase 2 scenario is to revive the ART OLYMPIC GAMES, which last edition was in 1948.

Keywords: cultural and creative economy,innovation process,cultural heritage,recruitment system,competitions and contests
Cyclic Peptide Platform as an Approach to Target Validation (CPTarget)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2241271.0
EU funding (EUR): 2241271.0
Participants: 1
Project status: SIGNED

The current ‘genomics’ era is an exciting time for drug target discovery with considerable opportunities for therapeutic intervention. Whilst classical small molecules remain the reagents of choice as chemical probes for target validation, not all targets are tractable with small molecules. There is thus an urgent need to develop methods for more efficient target validation, not only of individual proteins but also of protein-protein and other complexes. Natural product like cyclic peptides have enormous potential as a chemical platform for target validation. Recent technological advances have enabled the efficient production and screening of large libraries containing non-proteinogenic residues. De novo cyclic peptides with high affinity and selectivity for target proteins can be readily generated, even for protein-protein interaction targets perceived as challenging. Development of this technology and their innovative applications as outlined in our proposal will provide a step-change in methodology, and transform the current approach for studying the biological function of the target / pathways, enabling new ways to investigate potential targets. We aim to develop innovative chemical and molecular techniques to explore the applications of natural product-like cyclic peptides in target validation for very challenging targets. Ultimately the work aims to enable the development of new therapeutic agents targeting multiple diseases.

Keywords: cyclic peptides,screening technology,chemical probes,affinity probes,epigenetics,histone modifications
Market Design: Theory and Applications in Development (Market Design)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-08-01
End date: 2022-07-31
Duration (months): 72.0
Total project cost (EUR): 1516287.5
EU funding (EUR): 1516287.5
Participants: 1
Project status: CLOSED

There are two components to my research plan. First is the study of dynamic markets for real and financial assets in which traders might have asymmetric information. In particular I aim to understand how different characteristics of the market such as frequency of trade and transparency affect the efficiency with which these markets operate. This is a stepping stone to then be able to understand how these markets can be designed or regulated to improve their efficiency. Allowing for competition among market places can also indicate if the best way to intervene in these markets is by fostering competition or if direct government intervention is called for. Second, market imperfections are exacerbated in developing countries due to the poor rule of law and poor institutional framework. Thus, important welfare gains can potentially be achieved by mitigating these imperfections and fostering the development of markets. I plan to work on these issues by combining theoretical analysis with controlled randomized trials to validate the theoretical insights in the field. For example there are many durable goods such as solar lights that would greatly enhance the welfare of poor rural households. These markets have been very slow to develop due to the lack of credit of final consumers and uncertainty about product quality. By properly designing the self-enforcing agreements between the producers of these goods and the retailers we can ensure retailers get access to financing from the producers. In turn this would allow retailers to extend financing to final consumers. Work on the field will surely uncover other frictions which we can study theoretically how to overcome and again test in the field with further controlled randomized trials.

Keywords: mechanism design,asymmetric information,dynamic incentives
Clinical study in Parkinson's disease with two unique goals: 1) Proof-of-concept of CDNF protein for disease modification; 2) Validation of clinically tested device for intracerebral drug delivery (TreatER)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Ireland,Belgium,Sweden,Finland,Sweden,United Kingdom,Denmark,United Kingdom
Call: New therapies for chronic diseases (H2020-SC1-2016-RTD, 2016)
Start date: 2017-01-01
End date: 2020-12-31
Duration (months): 48.0
Total project cost (EUR): 8705549.75
EU funding (EUR): 5971173.75
Participants: 14
Project status: CLOSED

The main focus of TreatER is conducting a randomized, placebo-controlled, first-in-human, proof-of-concept, safety and efficacy study of intracerebrally administered CDNF protein therapy in patients with Parkinson’s disease (PD), using a neurosurgically implanted Drug Delivery System (DDS), which will also be clinically validated in the study. Thus the TreatER project has two independent goals, either of which alone can have significant impact addressing unmet clinical needs in chronic diseases, and advancing innovative European technologies: 1) Proof-of-concept of CDNF protein therapy for disease modification in PD. The patented European innovation CDNF has further potential in other ER stress related indications. 2) Clinical validation of DDS, an already clinically tested approach for accurately targeted intracerebral infusions in PD. The patented European innovation DDS has also significant potential in other indications needing intracerebral infusions. The clinical study builds on extensive preclinical research and related data on CDNF, including completed acute and chronic toxicology studies in non-human primates supporting an excellent safety profile. Further, the clinical study builds on existing clinical experience on DDS and related neurosurgery. Both conventional and novel means for assessing the efficacy of the treatment will be utilized. This requires strong interdisciplinary expertise and knowledge available in the consortium, including: Regulatory expertise in drug and medical device development; neurological and neurosurgical expertise in PD; PET imaging expertise specific to PD; Scientific expertise in novel neurotrophic factors, in specific CDNF; and GMP manufacturing expertise of novel biological drug compounds. Clinical trial applications are currently being submitted in Finland and Sweden, in accordance with previously obtained scientific advice from regulatory authorities in those countries as well as from MHRA (UK) and EMA's ITF.

Keywords: parkinson s disease,er stress,endoplasmic reticulum stress,cdnf,intracerebral administration
The Global Sites of International Criminal Justice (JustSites)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 1497436.0
EU funding (EUR): 1497436.0
Participants: 1
Project status: SIGNED

JustSites studies the multitude of localities in which international criminal justice is produced, received and has impact. Building an innovative scientific vocabulary, the project understands these justice sites to be social topographies in which the political, legal and professional activities that collectively create international criminal justice are developed. The justice sites include locations in which forensic exhumations are carried out, NGO offices in conflict zones, foreign ministries, private law firms, media outlets, academic research centers, and the international criminal courts. These sites are closely related, and all depend on and compete with each other to define the direction of international criminal justice. With its analysis of justice sites, the project moves beyond the conventional focus on courts and their context to investigate instead the balances of authority and power that affect the relations between these topographies and thus drive the development of international criminal justice as a field of law. To investigate the relational topography of justice sites, the multidisciplinary project analyzes how these sites produce international criminal justice ideas and practices, and how such ideas and practices are received and have impact in other sites. By following the impact of ideas and practices as they move from one site to another, the relative and perceived authority and power of these sites will be identified and analyzed. Through their productive and receptive character, the justice sites also communicate the results of international criminal justice to broader audiences, labelling them in the process as a success or a failure. Therefore, contributing the first investigation of the topography of justice sites is not only of significant value as frontier research, but is crucial for understanding the wider societal, legal and political impact of this field of law.

Keywords: international criminal justice,sociology of law,globalization of law
Copernicus CAL/VAL Solution (CCVS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Coordination and support actions
Countries involved: Estonia,Italy,Germany,Belgium,Norway,Belgium,France,France,France,Netherlands,United Kingdom,United Kingdom
Call: Copernicus evolution: new concept for an innovative and holistic solution for Sentinels calibration & validation (H2020-SPACE-2020, 2020)
Start date: 2020-12-01
End date: 2022-11-30
Duration (months): 24.0
Total project cost (EUR): 3053201.45
EU funding (EUR): 2999960.0
Participants: 15
Project status: SIGNED

The objective of the Copernicus Cal/Val Solution (CCVS) is to define a holistic solution for all Copernicus Sentinel missions (either operational or planned) to overcome current limitations of Calibration and Validation (Cal/Val) activities. Operational Cal/Val is required to ensure the quality of and build confidence in Copernicus data. However, these activities are currently limited by the following considerations: • The requirements and objectives need to be revisited to consider new usage of Copernicus products, inter-operability requirements, and to anticipate the needs of future Copernicus missions • Current Cal/Val activities are constrained by programmatic and budgetary requirements and do not necessarily follow scientific priorities • Cal/Val activities depend on the operational availability of high-quality Fiducial Reference Measurements (FRM) which are today mostly provided by external entities without strong commitment to the Copernicus program • Synergies within Copernicus and with other national and international programs are not systematically explored. To address these limitations CCVS will propose: • An updated specification of Cal/Val requirements for the Sentinel missions, taking into account inter-operability needs • An overview of existing Calibration and Validation sources and means • A gap analysis identifying missing elements and required developments in terms of technologies and instrumentation, Cal/Val methods, instrumented sites and dissemination service. • A comprehensive Copernicus Cal/Val Solution to organize the long-term provision of FRM for Sentinel missions • A roadmap documenting how the Cal/Val Solution can be implemented, highlighting responsibility, cost and schedule aspects. This plan will be elaborated in concertation with all stakeholders through four Working Groups gathering European Space Agencies, Copernicus Services, measurement networks and International partners.

Keywords: copernicus,earth observation,metrology
Probes of new physics and technological advancements from particle and gravitational wave physics experiments. A cooperative Europe - United States - Asia effort. (PROBES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Germany,Italy,Spain,Italy,Italy,Hong Kong,Switzerland,China,Switzerland,Switzerland,Poland,Georgia,France,France,United States,Netherlands,United Kingdom,United Kingdom,Japan
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2022-03-01
End date: 2026-02-28
Duration (months): 48.0
Total project cost (EUR): 2079200.0
EU funding (EUR): 2079200.0
Participants: 28
Project status: SIGNED

PROBES will explore elusive aspects of the Standard Model (SM) of particle physics and the Standard Model of Cosmology (SMC) and search for new physics exploiting particle accelerators and gravitational wave (GW) interferometers. Several low-energy aspects of quark-gluon interactions still remain a challenge, like the mechanism of color confinement, which accounts for 99% of the mass of standard matter of the Universe, and the equation of state (EoS) of ultradense matter, fundamental for the study of compact stars. Astrophysical observations and particle physics anomalies point towards the existence of Dark Matter (DM). Major efforts are dedicated to the search for galactic DM or hints at particle accelerators. The observation of neutrino oscillations established a picture consistent with the mixing of three neutrino flavours in three mass eigenstates and small mass differences. Experimental anomalies suggest the existence of sterile neutrino states participating in the mixing and not coupling to the SM gauge bosons. Lepton mixings and massive neutrinos offer a gateway to deviations from the SM in the lepton sector including Charged Lepton Flavour Violation. GWs provide alternative ways to study these phenomena. They could probe the existence of primordial black-holes as a possible DM candidate, test the SMC through new measurements of the Universe expansion rate, and the neutron star EoS through the “tidal” perturbations during a binary neutron star merger. Joint EM-GW-neutrino observations could probe astrophysical sources and constrain physics under extreme conditions of electromagnetic and gravitational fields. We are leading the development, commissioning and data analysis of cutting-edge experiments to answer these questions. This requires maximum knowledge sharing and technological advancements with applications also outside fundamental physics. The collaboration with world-class laboratories in US and Asia will open new career prospects for the participants.

Keywords: flavour physics,neutrino oscillations,charged lepton flavour violation,dark matter,nuclear structure,black holes,neutron stars,gravitational wave detectors,physics,particle accelerator physics