Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
OpenAIRE Advancing Open Scholarship (OpenAIRE-Advance)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: e-Infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Uruguay,Iceland,Austria,Germany,Germany,Germany,Estonia,Ireland,Italy,Israel,Spain,Italy,Cyprus,Malta,Switzerland,Norway,Serbia,Türkiye,Belgium,Finland,Greece,Greece,Hungary,Lithuania,Poland,Slovenia,Greece,Norway,Slovakia,Sweden,Switzerland,Bulgaria,Greece,Croatia,Romania,Latvia,France,Czechia,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,Portugal,Denmark,United Kingdom,United Kingdom,Luxembourg,Portugal
Call: Data and Distributed Computing e-infrastructures for Open Science (H2020-EINFRA-2017, 2017)
Start date: 2018-01-01
End date: 2021-02-28
Duration (months): 38.0
Total project cost (EUR): 9999997.5
EU funding (EUR): 9999997.5
Participants: 55
Project status: CLOSED

OpenAIRE-Advance continues the mission of OpenAIRE to support the Open Access/Open Data mandatesinEurope. By sustaining the current successful infrastructure, comprised of a human network and robust technical services, it consolidates its achievements while working to shift the momentum among its communities to Open Science, aiming to be a trusted e-Infrastructurewithin the realms of the European Open Science Cloud.In this next phase, OpenAIRE-Advance strives to empower its National Open Access Desks (NOADs) so they become a pivotal part within their own national data infrastructures, positioningOA and open science onto national agendas. The capacity building activities bring together experts ontopical task groups in thematic areas(open policies, RDM, legal issues, TDM), promoting a train the trainer approach, strengthening and expanding the pan-European Helpdesk with support and training toolkits, training resources and workshops.It examines key elements of scholarly communication, i.e., co-operative OA publishing and next generation repositories, to develop essential building blocks of the scholarly commons.On the technical level OpenAIRE-Advance focuses on the operation and maintenance of the OpenAIRE technical TRL8/9 services,and radically improvesthe OpenAIRE services on offer by: a) optimizing their performance and scalability, b) refining their functionality based on end-user feedback, c) repackagingthem into products, taking a professional marketing approach with well-defined KPIs, d)consolidating the range of services/products into a common e-Infra catalogue to enable a wider uptake.OpenAIRE-Advancesteps up its outreach activities with concrete pilots with three major RIs,citizen science initiatives, and innovators via a rigorous Open Innovation programme. Finally, viaits partnership with COAR, OpenAIRE-Advance consolidatesOpenAIRE’s global roleextending its collaborations with Latin America, US, Japan, Canada, and Africa.

Keywords: open access infrastructure,open science,open scholarship,open research data,research information system,open access monitor,open science observatory,european open science cloud,eosc
Autonomous Cable assembly Enabler (ACE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cables are at the heart of electronic equipment that serves the medical, marine, aerospace, communications and automotive industries. The assembly of electrical cables is primarily based on human workmanship - however, manual assembly of cables is a delicate art that increases product cost, reduces quality as well as increases supply chain lines and cost. As a means to increase profitability, cable manufacturers from Europe have relocated their production facilities to low cost labour regions like North Africa, Mexico and China. Because of technological advances and statutory regulations as defined by IPC/WHMA-A-620 standards, it no longer viable to continue with manual assembly. There is an imminent need to develop machines that allow to automate the assembly to meet the standards requirements. As Frisimos, we have developed a evolutionary automated robotic assembly machines that will disrupt the electric cable assembly industry. The project idea is composed of three modules that can work as standalone machines or together forming a process line. The Layer Removal machine that enables cutting of metal with almost no heat, and to separately cut each layer with precise profile, is based on Laser ablation process, which uses specific wavelength and additional parameters. The Wire Sort machine that allows sorting cable wires according to their color or lettering, is based on a machine vision based algorithm. The Wire soldering machine welds the cable by laser, using a laser beam, which allows controlling the soldered spot size and the power, so creating the most optimal soldering. We will specifically concentrate on the automotive and communications market segments. The targeted market potential for our solution will grow from €12.29b in 2017 to €19b by 2022. We anticipate that ACE will help grow our turnover to €35.45m with a cumulative profit of €50m within the first 5-years of commercialisation.

Keywords: cables assembling,automation,laser soldering,machine vision based algorithm
Enabling high performance and cost-efficient Point-of-Care diagnostics using a new innovative synthetic lateral flow substrate (SyntheticPaper)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Mercene Labs is a Swedish SME with expertise in material design for adhesion and surface control developing products that benefit quality of life worldwide through creating unique solutions based on our proprietary Ostemer™ polymer platform. Our newest product Synthetic Paper comes from an urgent industry need to increase the performance of point-of-care (PoC) medical diagnostic tests by finding better alternatives to the traditional paper-based lateral flow products currently in use. Improvements in the performance of lateral flow assays could lead to more rapid clinical decision making and timely interventions with appropriate treatments as well as more personalized healthcare benefiting millions of patients worldwide. Synthetic Paper provides superior material properties in terms of repeatability in geometry and surface energy while being able to directly replace nitrocellulose strips in current readers while utilizing the existing POC readers and infrastructure. Currently Mercene Labs is able to provide Synthetic Paper in A4 sheets with a native (untreated) surface, as well as surfaces modified for specific liquid flow speed. However, manufacturers of PoC tests are used to purchasing test strip material that is ready for antibody bonding. The feasibility study, performed under this SME Phase 1 project, will focus adding to the product offering by modifying the surface to offer customers a higher value product. Additionally, the feasibility study will focus on developing a pricing strategy and a business model for Synthetic paper.

Keywords: point of care testing,polymer technology,polymer based substrates
100% Renewable Energies for Energy Intensive Industries (RE4Industry)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Spain,Austria,Germany,Spain,Belgium,Greece,Greece,Netherlands,Netherlands
Call: Market Uptake support (H2020-LC-SC3-2020-RES-IA-CSA, 2020)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 2999500.0
EU funding (EUR): 2999500.0
Participants: 11
Project status: SIGNED

The EU has started a progressive decarbonisation with the aim to become carbon neutral by 2050. Energy Intensive Industries (EII) are expected to play an important role in this transition as they represent 24% of the final energy consumption, but a clear long-term vision and strategy is required in order to remain competitive while contributing to the decarbonization targets of the EU. RE4Industry has been conceived under this framework with a twofold objective: to support EII in the identification and integration of renewable energy (RE) solutions together with the definition of Action Plans for decarbonisation, and to transform the EU industrial landscape into a large market niche for the uptake of RE while defining the appropriate framework conditions for short- and long-term scenarios. To this end, RE4Industry will set up and empower a comprehensive network of stakeholders and market actors who will identify feasible RE technologies and their market barriers and will interact with industry representatives to gather their needs, expectations, drivers and barriers towards the implementation of these technologies. Such an approach will be accomplished through a strong engagement strategy and the creation of RE4Industry Collaborative Network, who will receive from the project partners knowledge transfer material such as success cases, best practices, policy recommendations and technological roadmaps for promoting RE adoption. In parallel to the networking activities, RE4Industry will develop a baseline methodology for the design of Action Plans for decarbonisation in EIIs that will be developed and validated together with 3 representative industrial use cases from the steel, aluminium and chemical sectors. RE4Industry solid replication strategy will enable the roll out of this methodology in at least 8 additional use cases of different sectors within the project lifespan and the initiation of cross-border knowledge transfer activities to a total of 12 EU countries.

Keywords: energy intensive industries,descarbonisation,renewable enertgy technologies,market support
Glioblastoma Subtype Avatar models for Target Discovery and Biology (iGBMavatars)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-07-01
End date: 2023-06-30
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The Glioblastoma Multiforme (GBM) is the most common primary brain tumor and it is incurable. Two major challenges affect GBM clinical management: its heterogeneity (which treatment will best fit this very patient?) and its resistance to available treatments (will the patient benefit in any way from the chosen therapy?). Here we approach these questions with a personalized entry point. First, we aim to create “humanized” experimental models of GBM accurately reflecting patients at molecular level. These GBM Subtype Avatars models (GSA) will be exploited as “targeted patients” in personalized biology and intervention studies. Since GBM exists as molecular subtypes with similar histopathology but mutually exclusive genetic lesions and molecular features, we will generate GSA by targeting mutations recurrently associated with Proneural, Classical or Mesenchymal GBM subtypes into adult human neural stem cells (NSC). Evidence supports that these cells can give rise to high-grade gliomas when engineered with the appropriate genetic lesions. Next, engineered NSC will be orthotopically implanted into immunocompromised rats and the resulting tumors profiled for gene expression, DNA methylation and copy number aberrations. These profiles will be compared to those generated in patient-derived xenografts and biopsies. Second, to identify drug targets favoring patients’ response to the current standard of care, we will exploit GSA for state-of-art genetic screens in vivo. Specifically, we will seek for synthetic lethal interactions between DNA damaging agents and the GSA transcriptome using an in vivo CRISPRi screening approach. Third, to investigate the molecular basis of GBM heterogeneity in GSA models, we will combine genetic and immunophenotypic tracing with gene expression and epigenomic profiling. Identifying tumor-specific vulnerabilities in a dismal disease urging for effective therapies and its molecular fingerprinting convey conceivably rapid Translation in Oncology.

Keywords: avatar tumor models adult neural stem cells,in vivo crispri screens,epigenetics and gene regulation,mechanisms of resistance
Road to Friday of Science 2.0 (ReFocuS 2.0)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Serbia,Serbia,Serbia
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-06-01
End date: 2020-01-31
Duration (months): 20.0
Total project cost (EUR): 198100.0
EU funding (EUR): 190000.0
Participants: 4
Project status: CLOSED

The aim of Road to Friday of Science (ReFocuS 2.0) project is to refocus and promote the value of cultural heritage and natural resources to society and highlight the important role that communities play in preserving and managing their cultural heritage and natural environment. The potential that cultural heritage offers is enormous, and beneficial to everyone. Following the EU and UNESCO tendencies and guidelines which recognize the importance of cultural and natural heritage as an indicator and facilitator of the social development, we refocus public attention to synergy of education, cultural and natural heritage, and sustainable development. The other aim of the project is to pay more attention to: academics to share their knowledge and work with broader public and this way to provide effective heritage education, young people to keep the national treasures and protect national heritage, and general audience to be aware of cultural diversity as a fundamental component of sustainable development. The ReFocuS project named “Past means Future” consists of two parts: Night 2018 will be focused on “Past”, while Night 2019 will be focused on “Future”. Cultural heritage and natural resources are based on aspects of our past that we cherish, want to keep and pass on to future generations and outside world. Researchers will participate in a wide range of activities developed for and aimed at young people and adults. The activities will take place in venues such as old streets and houses, museums, archaeological sites, fortress, science clubs, and libraries in twelve Serbian cities with the aim of showing the relevance of their work to our everyday lives as well as engaging ordinary people with research and bringing research to unusual places. Workshops, lectures, exhibitions, conversations and film screening about the cultural and natural heritage of Serbia will be organized within the local Science Clubs.

Keywords: past,future,cultural and natural heritage
Tracing of pulmonary neuro-immune networks (TOPNIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-03-14
End date: 2020-04-07
Duration (months): 24.0
Total project cost (EUR): 160635.6
EU funding (EUR): 160635.6
Participants: 1
Project status: CLOSED

Group 2 innate lymphoid cells (ILC2) are strategically positioned at mucosal surfaces, regulating mucosal defense, tissue homeostasis and inflammation. ILC2 contribute to the pathogenesis of allergic airway diseases, and pulmonary neurons have been also implicated in allergic conditions, such as asthma. Interestingly, recent studies demonstrated that ILC2 exert their function in the context of neuro-immune cell units that respond to environmental signals, steering mucosal immunity and repair. Nevertheless, the identity of the neuronal circuits innervating neuro-immune cell units and the nature of the bidirectional neuron-immune signals steering mucosal physiology remain elusive. Here, we hypothesize that pulmonary neuronal circuits provide and receive signals from ILC2, which steer immune responses in airway inflammation and infection. Initially we will use transgenic animals, engineered rabies virus and advanced imaging techniques to functionally map the innervation of neuron-ILC2 units. Sequentially, we will employ a combination of genetic, cellular and molecular approaches to determine how efferent neuronal activity controls pulmonary ILC2 biology and how ILC2-mediated effects impact on neuronal activity to maintain tissue homeostasis in the context of allergy and infection. Under this fellowship, we aim to establish how the interplay between neurons and immune cells steers tissue homeostasis. By identifying these new pathways, this action will contribute to the development of new therapeutic strategies in mucosal diseases that affect millions of people worldwide. Simultaneously, the fellowship will importantly strengthen the experienced researcher’s knowledge, skills and network to allow him to establish himself as an independent researcher.

Keywords: neuro immune interaction,mucosal immunity,group 2 innate lymphoid cells,asthma
FAKE NEWS AND REAL PEOPLE – USING BIG DATA TO UNDERSTAND HUMAN BEHAVIOUR (FARE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Portugal
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1499844.0
EU funding (EUR): 1499844.0
Participants: 1
Project status: SIGNED

Recent events, from the anti-vaccination movement, to Brexit and even to mob killings, have raised serious concerns about the influence of the so-called fake news (FN). False information is not new in human history, but the recent surge in online activity, coupled with poor digital literacy, consumer profiling, and large profits from ad revenues, created a perfect storm for the FN epidemic, with still unimaginable consequences. This challenge is interdisciplinary and requires academic research to guide current calls for action issued by academics, governmental and non-governmental agencies, and the social network platforms themselves. FARE will enrich current efforts, which mostly confront FN spreading from an applied perspective, by offering a theoretical framework that allows to make testable predictions. FARE argues that sharing of FN is a deviation from pure rationality and brings together 1) state of the art knowledge in behavioural psychology, to assess the role that cognitive biases play in susceptibility to FN, and 2) current models in network science and epidemiology, to test whether FN spread more like simple or complex contagions. Finally, fully recognizing that these novel big-data approaches carry great risks, FARE will develop a new strategy, mostly based on distributed computing, and guidelines to the ethical handling of human-related big-data. Together, FARE will offer a comprehensive model to ask questions such as: 1) What role(s) cognitive biases play in FN spreading? 2) How does network architecture affect FNs spread? 3) How do biases and position on networks build on each other to impact propagation? 4) What monitoring and mitigation interventions are likely to be more efficient? Moreover, the study of FN from such a conceptual perspective has the potential to profoundly increase our knowledge on human behaviour and information spread, beyond specific problems, with implications for communication (science, political), economics, and psychology.

Keywords: cognitive biases,information spread,fake news,contagion,ethics,big data,data analytics
Epigenetic fine-tuning of T cells for improved adoptive cell therapy (EpiTune)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 1489725.0
EU funding (EUR): 1489725.0
Participants: 1
Project status: SIGNED

Adoptive T cell therapy is a promising approach in various clinical settings, from target-specific immune reconstitution fighting cancer and chronic infections to combating undesired immune reactivity during auto-immunity and after organ transplantation. However, its clinical application is currently hampered by: 1) the acquisition of senescence during the required in vitro expansion phase of T cells which limits their survival and fitness after infusion into the patient, and 2) the functional plasticity of T cells, which is sensitive to the inflammatory environment they encounter after transfusion and which might result in a functional switch from the desired effect (e.g. immunosuppressive) to the opposite one (pro-inflammatory). I want to tackle these obstacles from a new molecular angle, utilizing the profound impact of epigenetic mechanisms on the senescence process as well as on the functional imprinting of T lymphocytes. Epigenetic players such as DNA methylation essentially contribute to T cell differentiation and harbor the unique prospect to imprint a stable developmental and functional state in the genomic structure of a cell, as we could recently show in our basic immune-epigenetic studies. Therefore, I here propose to equip T lymphocytes with the required properties for their successful and safe therapeutic application, including their functional fine-tuning according to the clinical need by directed modifications of the epigenome ('Epi-tuning'). To reach these goals I want: 1) to reveal strategies for the directed manipulation of the epigenetically-driven mechanism of cellular senescence and 2) to apply state-of-the-art CRISPR/Cas9-mediated epigenetic editing approaches for the imprinting of a desired functional state of therapeutic T cell products. These innovative epigenetic "one-shot" manipulations during the in vitro expansion phase should advance T cell therapy towards improved efficiency, stability as well as safety.

Keywords: epigenetics,epigenetic editing,adoptive t cell therapy,t cell immunology,precision medicine