Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sustainable Transformation Of Rural Communities via Technical, social and Organizational innovations (STORCITO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Resilient, inclusive, healthy and green rural, coastal and urban communities
Action type: Innovation actions
Countries involved: Spain,Norway,Germany,Greece,Netherlands
Call: Innovating for climate-neutral rural communities by 2050 (HORIZON-CL6-2024-COMMUNITIES-02, 2024)
Start date: 2025-05-01
End date: 2028-04-30
Duration (months): 36.0
Total project cost (EUR): 5198310.21
EU funding (EUR): 4862797.7
Participants: 11
Project status: SIGNED

The sustainability challenges faced by rural communities in the European Union (EU) are multi-faceted, and empowering these communities to address them is crucial to achieve climate neutrality by 2050, since one-third of the EU population resides in rural areas and these areas house critical ecosystems and natural resources. STORCITO is a 36-month project that will focus on fostering innovation in three key areas and major challenges of rural areas in Europe: (1) sustainable management of resources and wildfire prevention, (2) transition of citizens to sustainable energy systems and (3) achievement of an inclusive climate-neutral mobility. To enable successful customized innovations for each challenge, different rural ecosystems have been selected as representative scenarios in the four main pedo-climatic zones in Europe (Atlantic, Mediterranean, Continental and Boreal), matching selected rural communities with the biggest challenges in the area. By the end of the project, STORCITO will provide the following technical, social and organizational innovative solutions: (1) new tailor-made nature-based solutions (NBS) to avert wildfires, (2) new digital dashboard with updated fire indexes; (3) new on-demand climate-neutral mobility app for rural users; (4) new organizational support manual to enhance community-energy systems; (5) new CCUS informative app; (6) tailored training and educational materials for stakeholders and general public, (7) guidelines for reproducibility and (8) policy recommendations to local administrations and other relevant rural stakeholders. These innovations will be co-created with rural stakeholders to respond to their needs and examined for their feasibility and/or drawbacks in different biogeographical regions. STORCITO will create a holistic and sustainable framework for rural development to not only address immediate challenges but also foster long-term resilience.

Keywords: wildfire prevention,nature based solutions,carbon capture,use and storage,community energy systems,climate neutral shared mobility,demand responsive transport,green and digital transition
Unleashing the flavour potential of plant-based foods via fermentation (FlavourFerm)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Innovation actions
Countries involved: Denmark,Austria,Spain,Sweden,Belgium,Poland,Italy,United Kingdom,Finland
Call: Microbiome for flavour and texture in the organoleptic dietary shift (HORIZON-CL6-2024-FARM2FORK-01, 2024)
Start date: 2024-11-01
End date: 2028-04-30
Duration (months): 42.0
Total project cost (EUR): 4619972.75
EU funding (EUR): 4484546.98
Participants: 17
Project status: SIGNED

FLAVOURFERM aims to optimize, demonstrate, and deploy fermentation technologies to unlock the flavor potential of plant-based foods and respond to consumer demand for tasty, nutritious, and healthy plant-based products. Precision fermentation, biomass fermentation, and traditional fermentation techniques will be optimized to improve the sensory properties (flavor and texture) as well as the protein content and bioavailability in plant-based foods. Innovative fermented foods will be developed by incorporating ingredients from the optimized fermentation techniques into food products. The production will involve animal-free recombinant casein obtained by precision fermentation, as well as fungal mycelia obtained from legume fermentation, to produce an array of novel food products in three business cases: plant-based cheese, plant-based meat, and plant-based milk. All novel ingredients and final products will be scaled-up and produced at pilot and pre-commercial scale in collaboration with industrial partners, which include both innovative SMEs and established manufacturers from different EU regions.

Keywords: bioinformatics gut microbiome health gastronomy sensory science
Universality Phenomena in Geometry and Dynamics of Moduli spaces (UniGeoDyM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 1609028.0
EU funding (EUR): 1609028.0
Participants: 1
Project status: SIGNED

Geometry and dynamics in the moduli spaces proved to be extremely efficient in the study of surface foliations, billiards in polygons and in mathematical models of statistical and solid state physics like Ehrenfest billiards or Novikov's problem on electron transport. Ideas of study of surface dynamics through geometry of moduli spaces originate in works of Thurston, Masur and Veech. The area is flourishing ever since. Contributions of Avila, Eskin, McMullen, Mirzakhani, Kontsevich, Okounkov, Yoccoz, to mention only Fields Medal and Breakthrough Prize winners, made geometry and dynamics in the moduli spaces one of the most active areas of modern mathematics. Moduli spaces of Riemann surfaces and related moduli spaces of Abelian differentials are parametrized by a genus g of the surface. Considering all associated hyperbolic (respectively flat) metrics at once, one observes more and more sophisticated diversity of geometric properties when genus grows. However, most of metrics, on the contrary, progressively share certain similarity. Here the notion of “most of” has explicit quantitative meaning, for example, in terms of the Weil-Petersson measure. Global characteristics of the moduli spaces, like Weil-Petersson and Masur-Veech volumes, Siegel-Veech constants, intersection numbers of ψ-classes were traditionally studied through algebra-geometric tools, where all formulae are exact, but difficult to manipulate in large genus. Most of these quantities admit simple uniform large genus approximate asymptotic formulae. The project aims to study large genus asymptotic geometry and dynamics of moduli spaces and of related objects from probabilistic and asymptotic perspectives. This will provide important applications to enumerative geometry, combinatorics and dynamics, including count of meanders in all genera, solution of Arnold’s problem on statistics of random interval exchange permutations, asymptotics of Lyapunov exponents and of diffusion rates of Ehrenfest billiards.

Keywords: random square tiled surfaces,lyapunov exponents,moduli spaces of abelian and quadratic differentials,masur veech volumes,meandric systems,billiards in rational polygons,asymptotics of intersection numbers
A completely biological and human tissue-engineered mesh produced from Cell-Assembled extracellular Matrix (CAM) in vitro for the treatment of Pelvic Organ Prolapse (POP) (POPTex)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-02-01
End date: 2024-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Pelvic Organ Prolapse (POP) is a major medical issue for women. It is estimated that 1 in 10 women will undergo a surgery to treat POP during her lifetime. To provide mechanical support to the slipping organ, strong and stiff synthetic meshes have been used. Transvaginal meshes are now withdrawn from the market in many countries due to high complication rates. Hence, there is a strong medical and societal need for breakthrough innovations. We propose a new paradigm targeting the fundamental problem of synthetic meshes, i.e., the foreign body reaction, by providing a completely biological, tissue-engineered mesh to treat POP. Our strategy is based on a unique, biological material: the Cell-Assembled extracellular Matrix (CAM) produced by cells in vitro. Robust CAM sheets are cut to produce yarn subsequently knitted into a mesh. In 12 months, this proof of concept (PoC) aims to deliver unambiguous experimental evidence that a CAM-based tissue-engineered mesh has the potential to become a relevant alternative surgical solution to treat POP. This project is divided in 2 main tasks: 1) Production and mechanical characterization of a human CAM mesh, and of an equivalent ovine mesh, with properties justifying a preclinical test. 2) In vivo validation of an allogenic CAM mesh in a female sheep model at 2 and 6 month. This PoC will provide: 1) Proof that a human CAM-based knitted mesh can have clinically relevant mechanical properties; 2) Demonstration that an ovine CAM mesh can be successfully implanted to treat POP in a clinically relevant, allogeneic, large animal model; 3) Direct comparison between the biointegration of an ovine CAM mesh setting and the inflammatory response to a synthetic mesh. Overall, this PoC will increase the technology readiness level of our product from 1-2 to 3-4 by validating the functionality and safety of CAM meshes in a relevant in vivo environment. These outcomes will lead us closer to clinical trials and support a commercial endeavor.
Transcription Factor-mediated Induction of Cardiomoycyte proliferation. (TraFICa)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-16
End date: 2025-05-15
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

Heart failure is a major global public health problem affecting over 23 million patients worldwide. There are no effective therapies for heart failure that regenerate the damaged heart muscle following injury such as a myocardial infarction. The adult mammalian heart has an extremely limited intrinsic capacity for regeneration due to the fact that mature cardiomyocytes are unable to proliferate. To date, attempts to re-induce proliferation in mature cardiomyocytes of the adult heart have not yet been translated into the human clinical context. Much remains to be learned about molecular mechanisms controlling cardiomyocyte proliferation in humans if the therapeutic potential for cardiac regeneration is to be realised. With my extensive training and expertise in molecular and stem cell biology I plan to generate and exploit an innovative live cell cycle reporter-based screening platform to identify Transcription Factors (TFs) that can be induce cardiomyocyte proliferation. The three major objectives of this research proposal are: 1. Develop a high-content screening system to monitor cardiomyocyte proliferation in 3D human cardiac organoids, which will then be used to: 2. Identify (combinations of) TFs that drive the human cardiomyocyte cell cycle. 3. Assess the therapeutic potential of TF activation for cardiac regeneration in a pre-clinical human cardiac model system. I will receive extensive training in the ex vivo cardiac tissue culture system (objective 3), which will complement my proven expertise in the generation of (genetically modified) 3D cardiac organoids and knowledge on cell cycle regulation (objective 1 & 2). Altogether, the tool development, results and training obtained during this project will put me in the forefront of the cardiac regenerative field.

Keywords: stem cells,3d cardiac organoids,cardiomyocytes,proliferation,cell cycle
Prehistoric & colonial landscapes across the Mediterranean (ACROSS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 3
Project status: CLOSED

Previous research on palaeolandscapes has overlooked a main driver of landscape change: the mobility of human societies. When groups move they take with them their technology and ideas, but also plants, or land-uses which merge with native environments and practices to give birth to transported landscapes. This can lead to significant and long-lasting landscape changes -i.e. deforestation, introduction of exotic plants, erosion- that can be traced back through the use of combined palaeoenvironmental and archaeological techniques. However, the study of transported landscapes and their environmental impact has only rarely been addressed so far, and it is especially needed in Mediterranean coastal areas where migratory and colonial processes have had a particularly active role in the modelling of landscapes for millennia. ACROSS will fill this existing gap in current research by analysing two areas at the two sides of the Mediterranean Basin: Abdera (Thrace) and Emporion (Catalonia). They account for a long history of prehistoric peopling, and have ancient colonial relationships with the foundation of the Greek colonies of Abdera and of Emporion by same cultural group, the Ionian tribe. An innovative approach combining multi-proxy palaeoecological analyses (pollen, non-pollen palynomorphs, plant macroremains, high-temporal fire reconstructions), and Landscape Archaeology datasets will be applied in both areas to reconstruct changes in vegetation, land-uses and landscapes following prehistoric migratory processes and colonial settling between the 6th millennia cal BC and the 4th century AD. A particular focus will be put in reconstructing landscape changes following Graeco-Roman colonial settling to assess 1) common and diverging trends in land-use and landscape shaping in culturally similar colonial landscapes over long distances, and 2) the interaction, integration and resilience of autochthonous and colonial practices and landscapes across the Mediterranean.

Keywords: palaeoenvironment,landscape archaeology,transported landscapes,human migrations,ancient colonization,palynology,fire history,mediterranean,greece,spain
Photonic chip based high-throughput, multi-modal and scalable optical nanoscopy platform (NanoVision)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Norway,Germany,Sweden
Call: EIC Transition Open 2021 (HORIZON-EIC-2021-TRANSITIONOPEN-01, 2021)
Start date: 2022-06-01
End date: 2025-05-31
Duration (months): 36.0
Total project cost (EUR): 2489571.25
EU funding (EUR): 2489571.0
Participants: 4
Project status: SIGNED

The invention of super-resolution optical microscopy (nanoscopy) has given us a glimpse of its impact in all fields of science and medical care. Imagine the new scientific discoveries that can be realized if every research and clinical laboratory is equipped with an optical nanoscope that can deliver super-resolution imaging enabling researchers a window to nanoscale biology. However, several pain points of the available solutions currently hinder wide scale penetration of optical nanoscopy, such as cost, complexity, small throughput and limited flexibility in terms of choice of resolution and field-of-view (FOV). NanoVision will fill this pressing gap in the market with an affordable, compact, multi-modal and high-throughput photonic-chip based optical nanoscopy. Present day nanoscope uses a simple glass slide to hold the sample and a complex and bulky microscope set-up to illuminate and image. We change the current paradigm to a mass-producible photonic-chip to hold and illuminate the sample and a simple and compact optical microscope to image it. Our radical idea is thus to take out laser light steering and delivery from the microscope and transfer it to a photonic-chip. Photonic-chip based nanoscopy improves the throughput by a factor of 100x, reduces the cost by a factor of 2x and provide flexibility in terms of resolution and FOV. These key differentiator of NanoVision will not only extend the present market of nanoscopy but could also open new market opportunities. Founded on two patent families, it has been brought up to TRL 4. A spin-off, Chip NanoImaging, CNI, has been incorporated. NanoVision will propel the technology to TRL 6 by developing a user-friendly prototype and validating its impact during year-long user tests. The business and market development activities will enable us to attract investments of Euro2M by 2024 with an estimated revenue of Euro60M by 2029.

Keywords: optical microscopy,optical waveguides,bio imaging,nanoscopy,super resolution microscopy,photonic chip
Networking for advancing excellence and capacity in light-weight castings for Foundry 4.0 in Poland - NetCastPL4.0 (NetCastPL4.0)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Information Science and Engineering
Countries involved: Poland,Italy,Finland
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-05-01
End date: 2027-04-30
Duration (months): 36.0
Total project cost (EUR): 1483993.75
EU funding (EUR): 1483993.75
Participants: 3
Project status: SIGNED

NetCastPL4.0 aims to enhance excellence and innovation capacity at AGH in the field of sustainable lightweight castings and to engage the country in pan-European collaborative efforts on this topic twinning with the Consiglio Nazionale delle Ricerche (Italy) and AALTO University (Finland). This will be achieved through an elaborate work plan and a comprehensive set of activities including knowledge transfer, exchange of best practices, the sharing of their research infrastructure, activation of stronger international mobility in research to counteract “brain drain” from Poland, the outreach to foundries of green castings solutions. The knowledge transfer will be achieved through in person training, staff/PhD student exchanges, webinars, thematic workshops, and scientific schools. To demonstrate the value of the twinning exercise, an exploratory research project will also take place to fabricate green lightweight castings components with enhanced mechanical performance and reduced CO2 footprint. In addition, the project will strengthen the research management and administrative skills of AGH staff in order to improve and make more sustainable its research ecosystem. Through the involvement of foundries and relevant lightweight castings industry, NetCastPL4.0 is also expected to help link innovative research with real foundries and industrial needs and therefore lead to the creation of new business opportunities. The knowledge and technology capacity gained through the networking activities in the RDs will be the driving force for create the assets to go beyond the end of the 3-year twinning establishing the Networking Pole for Lightweight Castings Sustainability, to foster the development and uptake of green lightweight castings products and processes innovation in Poland, increase the production and exploitation of intellectual property, grow the opportunities for collaborations with the foundry and industry.

Keywords: light weight castings,molding,networking foundries,sustainability,green processes
Multi-Material Design using 3D Printing (MADE-3D)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Germany,Greece,Italy,Latvia,Sweden,Austria,France,Czechia,Switzerland,United Kingdom
Call: Functional multi-material components and structures (RIA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 5483257.5
EU funding (EUR): 5482007.25
Participants: 14
Project status: SIGNED

Additive manufacturing (AM) has the economic potential to complement conventional manufacturing processes, especially in the production of complex, multi-material (MM) components. To exploit the full benefits of optimized lightweight structures, it is usually required to use multi-materials with different physical properties. Still, multi-material combinations from conventional processes are not transferable to AM, due to residual stresses, cracks or thermal expansion rates of the different materials. Furthermore, geometric shape and position tolerances, as well as recycling strategies for powder waste, post-processed waste and the component itself are not yet defined. Based on the 3D printing processes PBF-LB and DED, this project aims at the concurrent engineering of designing processable multi-material optimized alloys, development of design concepts for multi-material structures with specific simulations for load cases and topology optimizations, and an extensive process adaption. Alloy and process development will be aided by advanced integrated computational material engineering approaches that combine thermodynamics, microstructure, and process simulations through machine-/active learning, resulting in shorter material development cycles. For bulk and powder materials, recycling of multi-material components via innovative concepts will promote the sustainability of multi-material additive manufacturing. This adaption will lead to increased process reliability and speed, enabling the dissemination of MM manufacturing in AM for the entire industry. The consortium brings a wide range of international expertise to the table, from materials research and digitization to the manufacture of multi-material components. It consists of startups, research institutions and market leaders in additive manufacturing. Industrial end-users cover automotive, aerospace and aeronautic applications with specific use cases.

Keywords: multi materials,additive manufacturing,am,slm,pbf lb,ded