Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Bioelectrochemical Sensing of Sexually Transmitted Diseases (BSSTD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-15
End date: 2018-09-14
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The detection of sexually transmitted diseases (STDs) has become a serious medical concern around the globe, as the number of reported cases increases every year, particularly in the United Kingdom. Infection with STDs, such as Gonorrhea and Chlamydia can result in long term health issues, such as infertility, reproductive tract cancer, and poor perinatal outcome. The successful treatment of these diseases depends on a quick and reliable method of diagnosis, which will be the topic of this proposal. The overall goal of the proposed research is to develop a detection method for bacteria, associated with STDs, based on bioelectrochemical techniques. Specific objectives of the proposed research consist of the identification of a redox couple functioning as electron donor for bacterial oxidases, the specific binding of bacteria to a macroelectrode, the electrochemical recognition of immobilized bacteria at the macroelectrode, testing for false-positive and false-negative results, the varying of target cultures to extend the scope of the proposed research, and finally, the assembly of a biosensing device using disposable screen printed electrodes. The proposed technique will make use of a biochemical test for aerobic bacteria, the oxidase test, by adapting it for electrochemical detection. In doing so, high selectivity will be achieved by targeted binding of living bacteria to immobilized antibodies on an electrode, whereas sensitivity will be strongly increased through the localized electrochemical detection of the oxidase test product. To demonstrate the usefulness and applicability to medical diagnostics, an approach is proposed to transfer the presented proof of concept to portable screen printed electrodes, which will permit the routine use of this concept in a bioelectrochemical handheld device. The proposed research answers the European Commission’s call for the development of new technologies in the health sector and an urgent need in public health monitoring.

Keywords: biosensors,bioelectrochemistry,disease detection,stds
Confidentiality-preserving Security Assurance (CASCAde)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-11-01
End date: 2023-05-31
Duration (months): 67.0
Total project cost (EUR): 1485642.5
EU funding (EUR): 1485642.5
Participants: 1
Project status: SIGNED

This proposal aims to create a new generation of security assurance. It investigates whether one can certify an inter-connected dynamically changing system in such a way that one can prove its security properties without disclosing sensitive information about the system's blueprint. This has several compelling advantages. First, the security of large-scale dynamically changing systems will be significantly improved. Second, we can prove properties of topologies, hosts and users who participate in transactions in one go, while keeping sensitive information confidential. Third, we can prove the integrity of graph data structures to others, while maintaining their their confidentiality. This will benefit EU governments and citizens through the increased security of critical systems. The proposal pursues the main research hypothesis that usable confidentiality-preserving security assurance will trigger a paradigm shift in security and dependability. It will pursue this objective by the creation of new cryptographic techniques to certify and prove properties of graph data structures. A preliminary investigation in 2015 showed that graph signature schemes are indeed feasible. The essence of this solution can be traced back to my earlier research on highly efficient attribute encodings for anonymous credential schemes in 2008. However, the invention of graph signature schemes only clears one obstacle in a long journey to create a new generation of security assurance systems. There are still many complex obstacles, first and foremost, assuring "soundness" in the sense that integrity proofs a verifier accepts translate to the state of the system at that time. The work program involves six WPs: 1) to develop graph signatures and new cryptographic primitives; 2) to establish cross-system soundness; 3) to handle scale and change; 4) to establish human trust and usability; 5) to create new architectures; and 6) to test prototypes in practice.

Keywords: security assurance,attestation,topology,graph signature scheme,anonymous credential scheme,evolving dependable system,system of systems
Enterprise Europe Network innovation management specific services in the two new regions of Eastern France (EEN EF4INNO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: France,France,France
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 187598.75
EU funding (EUR): 187598.75
Participants: 3
Project status: CLOSED

EEN EASTERN FRANCE 4 INNO (EEN EF4INNO) aims to deliver innovation management services in the two new regions of Eastern France namely Bourgogne - Franche-Comte and Alsace - Champagne-Ardenne - Lorraine. These services consists in the Key Account Management of SME Instrument beneficiaries in the region assisting them throughout the project to receive proper coaching on the one hand as well as Enhanced Innovation management capacity services to SMEs with a potential to internationalize on the other hand. These services are delivered by the experts of the Enterprise Europe Network team of EEN EASTERN FRANCE

Keywords: innovation management,sme instrument,coaching
SUSTAINABLE WATER TREATMENT FOR EUROPEAN INDUSTRY - ACHIEVING REGULATORY COMPLIANCE AND ENVIRONMENTAL PROTECTION (CleanHydro)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Sweden
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-11-01
End date: 2017-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Industry activities such as manufacturing, mining or construction have to deal with the management of their stormwater and industrial process wastewaters, with high contents of suspended and dissolved pollutants that need to be treated before discharge. Disposal of residual wastewaters from an industrial plant is a difficult and costly problem. However, today's technology is either not effective at treating larger volumes of water, too complex or too costly. As a result, companies struggle to comply with regulations affordably, effectively and safely. This situation can force companies and projects to shut down or relocate to areas with less strict environmental protection regulations in order to avoid fines. The management of industrial stormwater is also one of the biggest environmental problems today, impacting water quality all over Europe, human's health and ecosystems. Additionally, industries face pressure on scarce water resources. Reuse of water can help reduce pressure and protect European water resources as well as reduce charges for water disposal. However, the reuse of wastewater requires more advanced water treatment technology, which is currently limited and expensive. CleanHydro combines 2 effective bio chemical treatments for the removal of a wide array of particulate and disolved pollutants: chitosan and BioMedia. Chitosan has widely proven its success as waste water treatment in USA, however we have improved this technology to make it more efficient and introduce it into the European Market. BioMedia is a new treatment made of a blend of natural components. It is carbon-negative and eco-friendly, cost-efficient and has proven to be highly efficient. CleanHydro is the solution that will allow companies comply with the strict European environmental protection regulations affordably and effectively, and even improve their current industrial processes by managing water in a more sound and sustainable way and at a lower cost.

Keywords: chitosan,stormwater,industrial water,wastewater,biomedia,bio treatment
Continuous Variable Quantum Communications (CiViQ)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Tackling grand interdisciplinary science and technology challenges
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Germany,Germany,Israel,Austria,Spain,Spain,Italy,France,France,France,France,Czechia,Denmark,United Kingdom
Call: FET Flagship on Quantum Technologies (H2020-FETFLAG-2018-03, 2018)
Start date: 2018-10-01
End date: 2022-03-31
Duration (months): 42.0
Total project cost (EUR): 9974006.25
EU funding (EUR): 9974006.25
Participants: 25
Project status: CLOSED

The goal of the CiViQ project is to open a radically novel avenue towards flexible and cost-effective integration of quantum communication technologies, and in particular Continuous-Variable QKD, into emerging optical telecommunication networks. CiViQ aims at a broad technological impact based on a systematic analysis of telecom-defined user-requirements. To this end CiViQ unites for the first time a broad interdisciplinary community of 21 partners with unique breadth of experience, involving major telecoms, integrators and developers of QKD. The work targets advancing both the QKD technology itself and the emerging “software network” approach to lay the foundations of future seamless integration of both. The technological advantage will more specifically aim to: - Design architectures and implement protocol extensions of flexible “software based” networks for midterm country-wide QKD reach. - Drive CV-QKD systems and components up to TRL 6, derive standardized set of interfaces, also allowing a network-aware software defined functionality and open modular development, and pursue cost reduction by seamless integration of off-the-shelf components. - Push CV-QKD performance boundary forward by developing high-performance photonic integrated circuits (PIC) for CV-QKD, i.e. opening the way for ultra-low cost systems, and improve further the CV-QKD hallmark coexistence capability with standard WDM channels, i.e. reducing dramatically the barriers to optical network co-integration. - Prepare actively for next-generation networks by developing core enabling technologies and protocols aiming at quantum communication over global distances with minimal trust assumptions. CiViQ will culminate in a validation in true telecom network environment. Project-specific network integration and software development work will empower QKD to be used as a physical-layer-anchor securing critical infrastructures, with demonstration in QKD-extended software-defined networks.

Keywords: secure communication,quantum key distribution,photonic networks,photonic components and systems
Polymer brushes - a sustainable bonding technology for dissimilar materials (RadiBond)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 2112500.0
EU funding (EUR): 1478750.0
Participants: 1
Project status: CLOSED

Technological developments are moving ever faster in our modern society, and so are the pressure put on industries to produce safe and sustainable products within a circular economy perspective. Hybrid assemblies, joints of dissimilar materials, are key in modern product design and found everywhere - in your smartphone, car, TV, dishwasher, in planes and so on. However, in modern products we increasingly rely on engineering plastics and fiber-reinforced plastic composites, which is intrinsically hard to bond to other types of material - and using industrial glue you cannot easily recycle the plastic part. This has become a major challenge that hampers development of better, more durable, longer living, and sustainable products in key manufacturing industries such as automotive, aerospace, medical device, electronics, renewables, offshore, consumer goods, etc. A prime example is the slow adoption of the most potent lightweight materials, high-performance plastics and plastic composites (70% weight reduction potential), in the transportation industry due to lack of acceptable joining methods – severely limiting the CO2 reduction potential of new cars and planes. RadiSurf has developed the groundbreaking RadiBond technology, based on nanometer-thin coatings of polymer brushes, that provide sustainable, ultra-strong and ultra-tight hybrid joints that can easily be reversed at product end-of-life for disassembly and recycling of the bonded parts. RadiBond is a key enabling technology bringing outstanding bonding performance and easy integration into existing manufacturing assembly lines. As the pioneer in the industrial utilization of polymer brushes, Radisurf are now targeting full-scale market launch of RadiBond. However, to succeed in the transition from a small R&D provider to a manufacturing company, support from the EIC Accelerator Pilot program is crucial for demonstrating industrial implementation and scaling of the chemical production capacity.
High Dimensional Heterogeneous Data based Animation Techniques for Southeast Asian Intangible Cultural Heritage Digital Content (AniAge)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Australia,Hong Kong,Taiwan, Province of China,Malaysia,Thailand,France,France,United States,Viet Nam,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 1705500.0
EU funding (EUR): 1705500.0
Participants: 12
Project status: CLOSED

Although computer animation technology has been extensively used for films and games, it remains largely labour-intensive and expensive, with recent blockbuster films (e.g. Avatar, Gravity) costing around $1 million per minute of footage. A lot of research efforts and technological breakthroughs are therefore necessary if it is to be widely applied to many low-cost applications, such as archiving and reproducing style-preserved intangible cultural heritage (ICH) contents. The project “AniAge” is designed to answer this very challenge, using Southeast Asian ICH as the main application. Southeast Asian ICHs, e.g. local dances and puppetry, are visually and culturally rich, but are unfortunately disappearing due to the globalized modernization. The overall aim of "AniAge" is two-fold. The first is to develop novel techniques and tools to reduce the production costs and improve the level of automation without sacrificing the control of the artists, in order to preserve the performing art related ICHs of Southeast Asia. This involves capturing and processing versatile visual performance data, which are heterogeneous in nature and gigantic in quantity. Two areas of technological innovation are aimed to be made, which are novel algorithms for 3D computer animation; and visual asset management with data analytics and machine learning techniques. The second is to promote knowledge exchange and dissemination between EU and Southeast Asian partners, with a view to fostering researchers and spreading knowledge. This will be achieved by having researchers participating in the well-designed research projects, workshops, seminars and open lectures. This consortium consists of six partners, two from the EU and four from Southeast Asia. Four work packages are designed, three for technological developments (digitalizing traditional performing arts - "DigAge", digital asset management - "ManD" and stylized animation production - "AniX") and one for dissemination ("Dissem").

Keywords: performing arts related to intangible heritage
Exploring and exploiting the potential of extinct genome sequencing (Extinction Genomics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-04-01
End date: 2021-03-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

Palaeogenomics is the nascent discipline concerned with sequencing and analysis of genome-scale information from historic, ancient, and even extinct samples. While once inconceivable due to the challenges of DNA damage, contamination, and the technical limitations of PCR-based Sanger sequencing, following the dawn of the second-generation sequencing revolution, it has rapidly become a reality. Indeed, so much so, that popular perception has moved away from if extinct species’ genomes can be sequenced, to when it will happen - and even, when will the first extinct animals be regenerated. Unfortunately this view is naïve, and does not account for the financial and technical challenges that face such attempts. I propose an exploration of exactly what the limits on genome reconstruction from extinct or otherwise historic/ancient material are. This will be achieved through new laboratory and bioinformatic developments aimed at decreasing the cost, while concomitantly increasing the quality of genome reconstruction from poor quality materials. In doing so I aim to build a scientifically-grounded framework against which the possibilities and limitations of extinct genome reconstruction can be assessed. Subsequently genomic information will be generated from a range of extinct and near-extinct avian and mammalian species, in order to showcase the potential of reconstructed genomes across research questions spanning at least three different streams of research: De-extinction, Evolutionary Genomics, and Conservation Genomics. Ultimately, achievement of these goals requires formation of a dedicated, closely knit team, focusing on both the methodological challenges as well as their bigger picture application to high-risk high-gain ventures. With ERC funding this can become a reality, and enable palaeogenomics to be pushed to the limits possible under modern technology.

Keywords: paleogenomics,extinction,genome reconstruction,conservation genomics,de extinction
Transport and Receptor Mechanisms of Human Solute Carriers (TRECEPTORS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: France
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2023-09-30
Duration (months): 66.0
Total project cost (EUR): 2050125.0
EU funding (EUR): 1480180.0
Participants: 2
Project status: SIGNED

Human solute carriers (hSLC) form a superfamily of integral membrane proteins that transport small molecules and ions across membranes, and their transport functions are essential to processes ranging from synaptic transmission to apoptosis. Moreover, some hSLCs are the cellular receptors of human and pathogenic proteins, and play important roles in organogenesis, as well as infectious diseases. The hSLC transport and receptor functions are involved in a wide range of pathological conditions, which makes them important emerging drug targets in cancer, psychiatric disorders, and infectious diseases. Despite their paramount importance in human physiology and pathology, the current understanding of hSLCs molecular mechanisms of function and pharmacology still relies extensively on prokaryotic homologs that serve as structural and molecular models. However, due to the evolutionary divergence of these homologs, they fall short of uncovering the complexity of the hSLCs’ architectures and molecular mechanisms. Here, we aim to unravel novel transport, receptor and pharmacological mechanisms of medically important hSLCs using a multidisciplinary biophysical approach. To achieve this, we will determine the high-resolution structures of hSLCs and their macromolecular complexes with other membrane, as well as soluble proteins. Moreover, we will complement and challenge the structural data with functional approaches to probe the proteins dynamics and thermodynamics, as well as computational approaches to aid in drug discovery. Our research will expand our current molecular knowledge on the hSLCs, and aid understanding their cellular functions, as well as, uncovering their tremendous pharmacological potential.

Keywords: human solute carriers,membrane protein structure,membrane protein dynamics,macromolecualr complexes,viral receptor,cell fusion,virus cell entry inhibitors,cancer therapy