Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Can blue economy interventions mitigate rural poverty and outmigration in land-drying eastern Africa? (BLUE-AFRICA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 2497250.0
EU funding (EUR): 2497250.0
Participants: 1
Project status: SIGNED

Coastal and rural villages in Eastern Africa are more likely to have mitigated or even avoided poverty and outmigration during the last three decades of land desertification and natural disasters when developing a sustainable blue economy providing alternative resources and livelihoods. To test this core hypothesis, we will rely on a long-term causal inference framework combining satellite imagery, artificial intelligence algorithms, and spatial matching statistical methods, but also multidisciplinary field surveys. More precisely, BLUE-AFRICA has the ambition to quantitatively and causally assess on the long term whether (i) maintaining productive coral reefs through the establishment of fisheries management, (ii) investing in mariculture, or (iii) developing nature-based tourism can be potential transformation pathways on the eastern African coast to improve wealth assets and prevent outmigration when arable land and terrestrial resources are vanishing under climate change. Four main objectives will be reached: 1. Mapping and characterizing all rural socio-ecological systems (RSES) on the coasts of Madagascar, Mozambique, and Tanzania, but also blue economy activities. 2. Building, testing and validating artificial intelligence algorithms accurately predicting the level of human poverty and outmigration across space and time in Africa from satellite imagery and auxiliary covariates. 3. Testing the causal link between the establishment of a blue economy activity and the level of poverty and outmigration in the drying rural eastern Africa over a long time period (up to 30 years) using a spatial matching method between control and treated RSES and then fitting several response curve models. 4. Identifying, visiting and understanding the ‘bright’ vs. the ‘dark’ spots, i.e., the RSES with the highest vs. lowest level of economic development and net migration using a deviance approach from model expectations, in-depth field surveys and statistical comparisons.

Keywords: food insecurity,outmigration,satellite imagery,artificial intelligence,spatial matching,bright spots,asset wealth,marine protected areas,mariculture,tourism,natural disasters
eMISsion-free HV and MV transmiSION switchgear for AC and DC (MISSION)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Norway,Germany,Italy,France,Spain,Ireland,Portugal,Switzerland,United Kingdom
Call: Development of MVDC, HVDC and High-Power Transmission systems and components for a resilient grid (HORIZON-CL5-2023-D3-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 13673290.48
EU funding (EUR): 10398632.46
Participants: 12
Project status: SIGNED

The use of fossil fuels and the emission of greenhouse gases (GHG) into the atmosphere must be minimised as fast as possible to reach a climate-neutral society by 2050. A vital prerequisite of the de-carbonisation is the rapid growth of renewables. In 2050 more than 60 % of electrical power is expected to come from wind and solar, both significantly more remote located than traditional thermal power generation. To achieve this, efficient grid-integration of renewables across Europe and globally requires the development of high-power transmission systems and components, and more specifically Medium Voltage DC (MVDC) and High Voltage DC (HVDC) switchgear. In existing grids MVAC and HVAC switchgear is filled with the insulation gas SF6, the world's most potent GHG with a global warming potential (GWP) of 24 300. SF6-emissions due to leakages during gas handling or defective sealings / compartments represents a significant part of the grid owners' total GHG emissions. MISSION project will develop and demonstrate three SF6-free products as key-levers for climate neutral power transmission based on the requirements defined by TSOs, filling critical gaps in future hybrid ACDC grids: 1. SF6-free HVAC circuit breaker will be developed and type tested by Siemens Energy and installed and demonstrated by Statnett in Norway and RTE in France reaching TRL 8, 2. SF6-free HVDC GIS will be developed and type tested by Siemens Energy in Germany reaching TRL 8, 3. MVDC circuit breaker will be developed and tested in relevant environment by G&W reaching TRL 6. In addition, MISSION will determine technical properties of different SF6-alternatives for application in AC and DC switchgear for high and medium voltage operation. MISSION will contribute to enable emission-free energy transmission and switchgear technology transition for a resilient and sustainable future electric grid.

Keywords: sf6 free,switchgear,circuit breaker,high voltage,medium voltage,alternating current,direct current
Optical Entanglement of Nuclear Spins in Silicon (OpENSpinS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1984375.0
EU funding (EUR): 1984375.0
Participants: 1
Project status: SIGNED

A major breakthrough in quantum information processing is expected once “qubits”, carriers of quantum information, can be reliably integrated and controlled in silicon – the basis of today’s advanced classical information technology. Previous qubit realizations used the electronic spin of quantum dots or dopants, i.e. atoms of a different species replacing silicon in the lattice. However, this approach has only allowed for the entanglement of qubits in immediate proximity, which has hindered increasing the size of silicon-based quantum information processing systems. In OpENSpinS, these limitations will be overcome by using the nuclear spins of erbium dopants as qubits. These are initialized, read-out and controllably entangled using photons in the minimal-loss band of existing fiber-optical infrastructure. To demonstrate the unique potential of this approach, the specific objectives of the proposal are: I) The fabrication of nanophotonic resonators with unprecedented Purcell enhancement to enable coherent spin-photon coupling, II) the direct optical addressing and control of nuclear spin qubits with long coherence, and III) the implementation of optically-controlled two-qubit quantum gates and entanglement, both within a node and over distance. The proposed system combines the advantages of two leading platforms for quantum information processing: the bandwidth and long-distance connectivity of photons at telecommunications wavelength with the robust control and hour-long qubit storage achievable with nuclear spins in silicon. As the proposed chip-integrated resonators can be manufactured using established processes of the semiconductor industry, the novel hardware platform implemented in OpENSpinS offers unique prospects for future up-scaling of quantum information processing systems and quantum networks.

Keywords: quantum networks,distributed quantum information processing,single emitters,nuclear spin qubits
Memory, Beliefs, and Economic Decisions (MemDec)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1936400.0
EU funding (EUR): 1936400.0
Participants: 1
Project status: SIGNED

This project builds on the psychology of memory to study how selective retrieval affects economic decisions by shaping beliefs and preferences. The general approach is one in which a person’s past experiences (both domain relevant and domain irrelevant) determine her “core” beliefs and preferences, but changing cues in the environment ignite selective retrieval of specific pieces of information, causing instability in beliefs and preferences. In this way, selective memory acts as a source of framing effects. One project studies belief formation, which is based on sampling of information shaped by similarity to cues (which include the hypotheses being assessed and irrelevant context) and by interference. A second project applies this approach to preferences, studying choice under risk (whereby people selectively retrieve from memory and simulate potential lottery outcomes) and intertemporal choice (whereby people use memory to simulate future rewards). A third project will apply these ideas to the field. Domains of interest are: i) survey measurement of how past domain relevant as well as domain irrelevant experiences shape the perception of new risks i) socio-economic identity and its effect on political opinions, ii) similarity in financial markets, beliefs and asset prices, iv) advertising, and v) instability of fairness norms.

Keywords: memory,beliefs,intertemporal choice,valuation,political opinions
AXILES Bionics: Solaris Project (Solaris Project)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Belgium
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-07-01
End date: 2026-02-28
Duration (months): 32.0
Total project cost (EUR): 3798295.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Lower-limb amputees face physical and psychological pains that marketed prostheses are unable to relieve. Axiles Bionics aims to fill the clear world-wide market gap with next-generation bionic prostheses combining advanced robotics & AI, ensuring complete adaptation to amputee’s lifestyle. By virtue of its features, our technology creates a revolutionary cost-effective market concept “Prosthetics-as-a-Service” (PraaS) with our Solaris design. Our PraaS model ensures component-to-component maintenance, daily data gathering & monitoring system, predictive maintenance, and continuous upgrades. The fitness to the job-to-be-done of our solution has been already proven by in-house studies, where more than 85% of tested subjects expressed their astonishment and defined it as a must-have. Data from these studies show significant increase natural gait, less peripheral pains (knees/hips/back) and restoring of physical and mental balance, clear proof of the superior added value of our solution.

Keywords: prosthesis,cloud computing,artificial intelligence,bionics
Stabilizing CROP yield under unfavourable conditions by molecular PRIM(E)ing (CropPrime)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Bulgaria,Belgium,Czechia,Ireland,South Africa,Argentina,Spain,United Kingdom
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 1054057.14
EU funding (EUR): 1002800.0
Participants: 12
Project status: SIGNED

Modern agriculture is expected to provide ever-increasing amounts of food and feed under uncertain climate scenarios and significant pressure from consumers and regulators for environmentally friendly solutions to combat abiotic and biotic stress associated yield losses. Biostimulants that can improve crop productivity in a sustainable way offer a plausible alternative to the heavily criticized synthetic agrochemicals. To achieve their full potential a science-based understanding of their beneficial effects and avenues for fine-tuning of their bioactivities are of utmost importance. The proposed project will bring together expertise in plant systems biology, chemical biology, as well as biostimulant preparation and characterization, to discover new and optimize existing biostimulants by tapping into innovative sources of natural compounds and integrative biology approaches for elucidating molecular mechanisms underlying stress priming. A global network of leading plant scientists in abiotic and biotic stress signaling from Europe, Africa, and South America, facilitated by an industrial partner specializing in biostimulants production and marketing, will channel their efforts to bring sustainable solutions for crop protection to the farmer. An extensive mobility program will facilitate optimal knowledge-sharing within the network, maximize the research outputs and ultimately lead to increasing the human capacity of the partners.
Development of a scalable respiratory diagnostic platform (SmartRespDx)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Spain
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-04-30
Duration (months): 10.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Chronic respiratory diseases affect 10% of people and are the third cause of death worldwide. They cause significant disability and social exclusion. A key problem is the large under and misdiagnosis of such diseases. Late diagnosis of the diseases leads to lack of treatment and a rapid decline of the disease causing severe exacerbation, frequent hospitalization and high mortality with huge costs to the healthcare systems. Through design thinking and lean methodology we discovered a market opportunity. The current tools in primary care are not suited for non-specialists to tackle lung disease diagnosis. They require difficult breathing procedures from the patients, leading to inaccurate tests and incorrect diagnosis. It also creates mistrust in the technologies leading to underdiagnosis through lack of testing. Our solution is a quick, easy and accurate tool that doesn't require patient effort. It can be used in any clinical setting, but is particularly suited for non-specialists in primary care for disease diagnosis and monitoring. The output is trained on the lung experts' decisions, providing a diagnostic support tool for quick and effective decision-making where it is needed most. Early diagnosis and follow-up allows clinicians to intervene and educate the patient when treatment can still have a positive effect on their lung function and reduces the huge burden to the healthcare system due to avoidance of the severe stages of the disease, saving an estimated 5 BN € in the EU from hospitalizations alone. The WomenTechEU program provides the unique opportunity to test our technology in the clinical setting to reach a TRL5/6 from current TRL4 and protect our intellectual property. It also means we can strengthen our gender and diversity hiring processes and develop our leadership skills. The project achieves a major milestone and creates the required evidence to add significant value to our company and attract private seed investment to move us closer to market.

Keywords: user centered design,healthcare innovation
Deciphering Gene Regulatory Networks governing Mammalian Sex Determination (EnhanceSex)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-04-01
End date: 2027-03-31
Duration (months): 60.0
Total project cost (EUR): 1651868.0
EU funding (EUR): 1651868.0
Participants: 1
Project status: SIGNED

During mammalian sex determination, the bipotential embryonic gonad adopts either testicular or ovarian cell fates. This process highly relies on precise expression of several pro-male versus pro-female factors, most of which are transcription factors (TFs) and signalling pathway components. Yet, we still do not understand the interplay and hierarchy among these factors, their direct target genes, the regulatory elements they bind to, nor do we have an in vitro system to address these questions. We recently explored the complex gene expression regulation of Sox9, a key pro-male factor, and identified several active testis-specific enhancers. Remarkably, deletion of one of these led to XY male-to-female sex reversal in mice. The presence of several functional enhancers highlights the complex gene expression regulation present during sex determination, which we aim to address here in a systematic manner. Furthermore, we recently developed a system to generate mouse and human gonadal progenitors from embryonic stem cells. Building on our exciting results, we seek to decipher the gene regulatory networks governing mammalian sex determination using in vivo and in vitro approaches. This proposal will pursue three complementary aims: (i) Identify target genes of the key factors controlling gonad formation; (ii) Map the regulatory elements bound by these factors; (iii) Develop an in vitro organoid system to model testis development. Using cutting edge techniques as CUT&RUN ChIP-Seq, ATAC-Seq, Promoter Capture Hi-C, CRISPR genome editing, organoid culture and 3D scaffolding development, we will address the complex gene expression regulation governing sex determination. Insights gained from this basic research will shed light on cell fate decisions in general, allow better diagnosis of many patients with Disorders of Sex Development, and offer an in vitro system to study gonad development and function with implications for understanding and treating infertility.

Keywords: mammalian sex determination,gene regulation,cell fate decisions,gene regulatory networks,enhancers,testis,sertoli cells,stem cells,organoids
Graph Signal Processing Models for Neurovascular Decoupling. (GRASPING NERVE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-02
End date: 2026-02-01
Duration (months): 28.0
Total project cost (EUR): 212295.04
EU funding (EUR): 212295.04
Participants: 1
Project status: SIGNED

Blood Oxygenation Level Dependent (BOLD) signal is a widespread functional Magnetic Resonance Imaging (fMRI) technique to non-invasively study brain activity, and it relies on the mechanism of Neurovascular Coupling (NC), i.e. changes in cerebral blood flow driven by neuronal activity. However, there are various confounding factors for NC, such as homoeostatic physiological changes, or NC uncoupling driven by certain pathologies. Currently, there is no method to disentangle the information associated with neuronal activity from the vascular response. This is an important issue in both physiological imaging and brain activity investigation, as the two signal sources act as competing confounding factors. Furthermore, although vessels are the main blood distribution system, they are mostly ignored when taking into account BOLD analyses. In this project, I will first create a graph model of cerebral vessels to assess “cerebrovascular connectivity”. I will then use graph signal processing, a novel signal processing technique based on graphs, to embed BOLD signal fluctuations into the vascular and the more traditional tractography-based graphs to disentangle the propagation of neuronal activity and blood flow in these two pathways. This technique will allow disentangling the components of NC non-invasively, offering new insight on brain activity and neurovascular coupling, and allowing further studies on pathological NC uncoupling, such as pre-surgical imaging for tumour. I will apply this model at the macro- (whole-brain) and meso- (grey-matter- layers) scale, connecting the properties of NC in functional imaging between them. The application will be validated in high (3 Tesla) and ultra-high (7 Tesla) MRI fields to address its feasibility for both research and clinical application. Finally, BOLD will be compared with non-BOLD functional techniques, such as Arterial Spin Labelling and Vascular Space Occupancy, to shed light into the imaging of NC and brain activity.