Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The roles of innate lymphoid cells and rhinovirus in asthma exacerbations (ASTHMAVIR)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: Netherlands
Call:  (ERC-2013-ADG, 2013)
Start date: 2014-03-01
End date: 2019-02-28
Duration (months): 60.0
Total project cost (EUR): 2499593.0
EU funding (EUR): 2499593.0
Participants: 1
Project status: CLOSED

Asthma exacerbations represent a high unmet medical need in particular in young children. Human Rhinoviruses (HRV) are the main triggers of these exacerbations. Till now Th2 cells were considered the main initiating effector cell type in asthma in general and asthma exacerbations in particular. However, exaggerated Th2 cell activities alone do not explain all aspects of asthma and exacerbations. Building on our recent discovery of type 2 human innate lymphoid cells (ILC2) capable of promptly producing high amounts of IL-5, IL-9 and IL-13 upon activation and on mouse data pointing to an essential role of these cells in asthma and asthma exacerbations, ILC2 may be the main initiating cells in asthma exacerbations in humans. Thus we hypothesize that HRV directly or indirectly stimulate ILC2s to produce cytokines driving the effector functions leading to the end organ effects that characterize this debilitating disease. Targeting ILC2 and HRV in parallel will provide a highly attractive therapeutic option for the treatment of asthma exacerbations. In depth study of the mechanisms of ILC2 differentiation and function will lead to the design effective drugs targeting these cells; thus the first two objectives of this project are: 1) To unravel the lineage relationship of ILC populations and to decipher the signal transduction pathways that regulate the function of ILCs, 2) to test the functions of lung-residing human ILCs and the effects of compounds that affect these functions in mice which harbour a human immune system and human lung epithelium under homeostatic conditions and after infections with respiratory viruses. The third objective of this project is developing reagents that target HRV; to this end we will develop broadly reacting highly neutralizing human monoclonal antibodies that can be used for prophylaxis and therapy of patients at high risk for developing severe asthma exacerbations.
Understanding the roles of kainate receptors in the hippocampus (HIPPOKAR)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: United Kingdom
Call:  (ERC-2013-ADG, 2013)
Start date: 2014-02-01
End date: 2019-01-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Kainate receptors (KARs) are often regarded as the last frontier of glutamate receptor research, since much less is known about their physiological roles compared with that of the other glutamate receptor subtypes. This field of research is very important not just because of the unique role that KARs play in neuronal function, including specific forms of synaptic plasticity, but because of the increasing evidence that KARs are involved in a plethora of brain diseases and that KAR antagonists are promising novel therapeutic targets. I propose to lead a highly multidisciplinary approach, in collaboration with colleagues at Bristol and strategic collaborators worldwide, to develop novel pharmacological and genetic tools, which will be rapidly disseminated to the neuroscience community. These tools will be used here to test hypotheses regarding functions of KARs in granule cells (GCs) in the dentate gyrus of the hippocampal formation, with a focus on mossy fibre long-term potentiation (LTP). We propose four interrelated objectives: (i) to develop potent and selective antagonists for the GluK2 subunit of KARs, (ii) to generate GC specific knockouts of the five KAR subunits, by floxing GluK1-5 and crossing with a GC-specific Cre recombinase mouse line, (iii) to use these and existing tools in a combined pharmacological and genetic approach, to understand the functions of KARs at mossy fibre synapses in acute and organotypic hippocampal slices. A new development will be to record simultaneously from synaptically coupled GC-CA3 neuronal pairs and to image Ca2+ from participating mossy fibre boutons, (iv) to extend these investigations to the study of mossy fibre function, in particular LTP, in anaesthetised animals and to establish the function of mossy fibre LTP in hippocampus-dependent learning and memory. Although highly ambitious, the proposal is based on a long track record of KAR research by the PI and his collaborators plus a substantial amount of preliminary data.

Keywords: synaptic plasticity,glutamate receptor
Blood regeneration: de novo development of human hematopoietic stem cells (DENOVOHSC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: United Kingdom
Call:  (ERC-2013-ADG, 2013)
Start date: 2015-01-01
End date: 2019-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Hematopoietic stem cells (HSC) are used in clinical therapies for leukemia and blood-related genetic disorders. Whereas the number of patients requiring treatment continues to increase, HSC transplantations are limited due to insufficient patient-matched donor HSCs. The current challenge is to create more matched HSCs. As evidenced by the Nobel Prize award this year, reprogramming of somatic cells to pluripotent stem cells (iPS) is one of the most important breakthroughs of recent times. This innovative advance contributes to our ability to reprogram patient-specific cells not only to pluripotency, but also to directly program them to other desired cell lineages. The study of healthy and diseased patient cells in this context will have huge impact on the development of new drug and cell-based treatments. My research is uniquely positioned at the interface of fundamental and translational research at the University of Edinburgh Centre for Inflammation Research and Centre for Regenerative Medicine. Through more than a decade of HSC developmental research, my group has shown that HSCs arise from endothelial cells in a natural reprogramming event. We are one of the few groups worldwide that can isolate these special endothelial cells and show that they yield robust transplantable HSCs (the gold-standard for clinically relevant HSCs). Using our unique expertise I aim to foster new translational strategies to de novo generate human HSCs from patient somatic cells. My aims are to 1) mark and manipulate the program for HSC generation during the endothelial to HSC transition (EHT); 2) define extrinsic molecules affecting EHT and engineer novel niches; 3) reprogram human somatic cells or endothelial derived iPS cells directly to HSCs. These aims will be realized through novel multi-color reporter mouse and ES/iPS lines indicating EHT in real-time, allowing for the isolation and functional validation of de novo HSC generation. These novel models and cultures will significantly advance research and technology, to have major impact on the field.

Keywords: blood stem cells,leukemia,transplantation
Rediscovering the hidden structure. A new appreciation of Juristic texts and Patterns of thought in Late Antiquity. (REDHIS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: The study of the human past
Countries involved: Italy
Call:  (ERC-2013-ADG, 2013)
Start date: 2014-02-01
End date: 2020-01-31
Duration (months): 72.0
Total project cost (EUR): 1396980.0
EU funding (EUR): 1396980.0
Participants: 1
Project status: CLOSED

The aim of REDHIS is to write a new history of the Roman legal culture in Late Antiquity. The project will focus on the elements which display the persistence of a legal culture of high level. Two are the main aspects that will be researched. First, a comprehensive understanding of legal culture has to include the study of the legal texts’ manuscript transmission. Although in Late Antiquity few works were composed anew, the books of the main classical jurists of previous centuries were copied, read and studied in the school and in the courts. A full appreciation of the remains of such copies in papyri and parchment – which has been neglected here so far – will explain how the lawyers of the 4th and 5th centuries AD kept in touch with the achievements of previous jurists. Secondly, Late Antiquity is considered to be the epoch of the emperors’ legislation, in opposition to the previous epoch dominated by private jurists. Nevertheless, a thorough analysis of the motivations of the emperors’ decisions will show the mental proceeding of the lawgivers and, at the same time, will show a deep relationship with the works of the roman jurists. The project will be developed, under the direction of the PI, by three research teams, with a strong cross-disciplinary composition. A wide collection of papyri and parchments will be edited, as a basis for a new interpretation, which will be the second part of the project. REDHIS will organize a series of workshops with the participation of scholars from different European countries. A final international conference on the legal culture in Late Antiquity will disseminate into the scientific community the results of the research. Four publications will be produced: a collection of the jurists' writings that have come down to us in direct tradition, i.e. outside the Digest; a monograph on the history and geography of Late Antique legal literature; a book on Justinian as a lawgiver; the proceedings of the international conference.

Keywords: roman law,history of roman legal science,late antiquity,papyrology,history of book,justinian.
The role of consciousness in adaptive behavior: A combined empirical, computational and robot based approach (CDAC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: The Human Mind and its complexity
Countries involved: Spain
Call:  (ERC-2013-ADG, 2013)
Start date: 2014-02-01
End date: 2019-01-31
Duration (months): 60.0
Total project cost (EUR): 2469268.0
EU funding (EUR): 2469268.0
Participants: 2
Project status: CLOSED

Understanding the nature of consciousness is one of the grand outstanding scientific challenges and two of its features stand out: consciousness is defined as the construction of one coherent scene but this scene is experienced with a delay relative to the action of the agent and not necessarily the cause of actions and thoughts. Did evolution render solutions to the challenge of survival that includes epiphenomenal processes? The Conscious Distributed Adaptive Control (CDAC) project aims at resolving this paradox by using a multi-disciplinary approach to show the functional role of consciousness in adaptive behaviour, to identify its underlying neuronal principles and to construct a neuromorphic robot based real-time conscious architecture. CDAC proposes that the shift from surviving in a physical world to one that is dominated by intentional agents requires radically different control architectures combining parallel and distributed control loops to assure real-time operation together with a second level of control that assures coherence through sequential coherent representation of self and the task domain, i.e. consciousness. This conscious scene is driving dedicated credit assignment and planning beyond the immediately given information. CDAC advances a comprehensive framework progressing beyond the state of the art and will be realized using system level models of a conscious architecture, detailed computational studies of its underlying neuronal substrate focusing, empirical validation with a humanoid robot and stroke patients and the advancement of beyond state of the art tools appropriate to the complexity of its objectives. The CDAC project directly addresses one of the main outstanding questions in science: the function and genesis of consciousness and will advance our understanding of mind and brain, provide radically new neurorehabilitation technologies and contribute to realizing a new generation of robots with advanced social competence.

Keywords: brain,consciousness,computational neuroscience,physiology,brain architecture,dual process theory,awareness,thalamus,neo cortex,cerebellum,hippocampus,forward models,sensori motor contingencies
A new paradigm in modelling flow and transport in porous media: revisiting foundations of porous media science (SCIPORE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Earth system science
Countries involved: Netherlands
Call:  (ERC-2013-ADG, 2013)
Start date: 2013-09-01
End date: 2019-08-31
Duration (months): 72.0
Total project cost (EUR): 2237200.0
EU funding (EUR): 2237200.0
Participants: 1
Project status: CLOSED

Our models of fluid-filled porous media are based on ad-hoc extensions of relatively simple equations. But, in almost all cases, they have failed to provide acceptable descriptions of complex porous media. In petroleum engineering, we are not able to predict the true reservoir behaviour; our predictions must be continuously revised through “history matching”. In soil physics, we find that persistent pesticides do reach deep groundwater resources contrary to our model predictions. Almost all models fail to predict the outcome of soil and groundwater remediation operations. Predictions of performance of industrial systems such as fuel cells and fluid absorbents are poor at the best. We are confronted with major challenges related to the prediction of performance and safety of subsurface CO2 sequestration, and questions related to threats and opportunities associated with methane gas hydrates under the oceans. One major shortcoming of our porous media models is the lack of consideration for the fact that fluids can fill up the pores in many different configurations, even for the same degree of fluid saturations. Each configuration results in different rates of fluids flow and in different mass and heat transport behaviours. Another major defect is the fact that our current models apply to continuous phases. But, in many applications, we have discontinuous fluid phases. The general aim of the proposed research is to establish a new paradigm for modelling flow and transport in porous media. We shall perform integrated experimental and computational research in order to establish advanced physically-based theories for description of porous media processes. We shall construct a host of micromodels for physical experiments on flow and transport and perform sandbox experiments on multiphase flow to study processes that occur in gas hydrates and fuel cells. In the course of this project, a first-class integrated experimental/computational laboratory will be established.

Keywords: multiphase flow and transport in porous media
Support to Policies - Set Up of a Bioeconomy Observatory (BISO project: Bioeconomy Information System and Observatory) (BISO)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Food, Agriculture and Fisheries, and Biotechnology
Action type: Coordination and support actions
Countries involved: European organisations area
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2013-03-01
End date: 2016-02-29
Duration (months): 36.0
Total project cost (EUR): 1641080.8
EU funding (EUR): 1490380.0
Participants: 1
Project status: CLOSED

On 13 February 2012, the European Commission adopted a strategy for "Innovating for Sustainable Growth: a bioeconomy for Europe" (COM(2012)60). The Communication presents a Bioeconomy Strategy and Action Plan whose goal is to emphasise the importance of the bioeconomy for Europe. Item 6 in the Bioeconomy Action Plan foresees the establishment of a Bioeconomy Observatory as follows: "Establish a Bioeconomy Observatory in close collaboration with existing information systems that allows the Commission to regularly assess the progress and impact of the bioeconomy and develop forward-looking and modelling tools." Indeed today there is not yet an integrated monitoring tool that would embrace the bioeconomy in all its dimensions and would be able to analyse the complex relationships across the various bioeconomy sectors (as well as with the "non-bioeconomy" sectors). The design of such a monitoring tool should allow addressing the whole bioeconomy across its sectors, their functioning, their interaction as well as the dynamics of their development. The present proposal aims to create such a monitoring tool through the set up of the Bioeconomy Observatory mentioned in the Bioeconomy Action Plan (observatory described in the text below as the Bioeconomy Information System and Observatory: BISO). This Information System will bring together and align data, indicators, modelling and forward-looking tools to regularly assess the progress and impact of the bioeconomy. The mission of the Bioeconomy Observatory will be to function as an integrated information source on the bioeconomy, providing a solid decision-making basis for policy development. The Bioeconomy Observatory will provide regular data and analysis for policy makers and stakeholders to monitor the development of the bioeconomy in order to support the implementation of the bioeconomy Strategy.

Keywords: bioeconomy,observatory,data,indicators,models,markets,research,policy,sustainability,forward looking analysis,monitoring,strategy,resource efficiency,horizon 2020
New systems, technologies and operation models based on ICTs for the management of energy positive and proactive neighbourhoods (E[PLUS])

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: ICT for a low carbon economy
Action type: Collaborative project
Countries involved: Spain,Spain,Netherlands,Belgium,Spain,Romania
Call:  (FP7-2012-NMP-ENV-ENERGY-ICT-EeB, 2012)
Start date: 2012-11-01
End date: 2014-04-30
Duration (months): 18.0
Total project cost (EUR): 5012167.0
EU funding (EUR): 3205329.0
Participants: 10
Project status: CLOSED

E+ aims to develop, implement and demonstrate a new energy management operation and business model based on ICTs, able to increase the energy efficiency at neighbourhood level, while achieving near zero emissions neighbourhoods. The new control system (E+) will be prepared to manage and control energy sources, stationary storage devices, street lighting, electric vehicles charging infrastructure, buildings loads, etc. Both, electrical and thermal (including geothermal) energy sources and consumption are considered in E+. Two demonstration sites are committed with E+: Málaga, in the South of Spain, and Mons, in Belgium. The results and conclusions coming from the demonstration activities will provide the basis for the elaboration of recommendations for energy positive urban planning. The consortium brings together relevant actors from three sectors: energy (KEMA), construction (ACCIONA, VSM) and ICTs (IBM, TEAMNET), working closely with research institutions (CIRCE, EIT, COMILLAS) and public authorities (MALAGA and IDEA). This multidisciplinary consortium has the required capabilities for bringing the E+ energy management system into the new market, exploiting this result in the frame of new and replicable operation and business models. In addition, the Spanish DSO ENDESA is fully committed with the project.

Keywords: energy management,districts,energy efficiency,neighbourhoods,icts,energy control,urban planning,interoperability,electric vehicle,renewable energy,emission reduction,cities
Energy Forecasting (NRG4CAST)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: ICT for a low carbon economy
Action type: Collaborative project
Countries involved: Slovenia,Italy,Italy,Greece,Germany
Call:  (FP7-2012-NMP-ENV-ENERGY-ICT-EeB, 2012)
Start date: 2012-12-01
End date: 2015-11-30
Duration (months): 36.0
Total project cost (EUR): 3751545.0
EU funding (EUR): 2313921.0
Participants: 8
Project status: CLOSED

NRG4Cast is developing real-time management, analytics and forecasting services for energy distribution networks in urban/rural communities. We are analysing information regarding network topology and devices, energy demand and consumption, environmental data and energy prices data. The services that will be integrated in a software module pipeline providing prediction and the decision support system based on network monitoring, anomaly detection, route cause analysis, trend detection, planning and optimisation. These services will be using advanced knowledge technologies in particular machine learning, data and text mining, stream mining, link analysis, information extraction, knowledge formalisation and reasoning. The platform will be tested in the two orthogonal case studies energy efficiency in municipalities and energy efficiency in city districts. The two case studies will be complemented with the additional energy networks operated by project partners; electric vehicles network, public lighting system and energy positive buildings. The proposal concentrates on electric power networks through the development of a generic framework that will be able to control, manage, analyse and predict behaviour in an extensible manner on other energy networks like gas distribution, heat water distribution and alternative energy distribution networks. For these reasons a generic toolkit with programmable data adapters will also be developed. Proposal gathers highly competent RTD organisations, developers, energy operators and case studies from four European countries. The project is led by JSI, has a consortium of 8 partners from 4 different countries and will run for 36 months.

Keywords: energy efficiency,data fusion,decision support system,environmental sustainability,infomobility