Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Flexible polymer-based biophotovoltaic devices for green hydrogen production (BioH2Gen)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 207183.12
EU funding (EUR): 207183.12
Participants: 1
Project status: SIGNED

In view of the urgent need to mitigate the environmental effects caused by the large amounts of CO2 released into the atmosphere, alternative strategies for energy production using renewable sources (water, wind, biomass, sunlight) have been deployed. Green hydrogen (H2) is an alternative to fossil fuels due to its clean and high energy density combustion, but still limited the low efficiency of production and high cost. To respond to these limitations, BioH2Gen proposes an alternative strategy for green H2 production through biophotovoltaic (BPV) devices, taking advantage of photosynthetic microorganisms to generate H2 through sunlight capture. More specifically, this project proposes the development of new nanostructured photoelectrodes based on flexible polymeric scaffolds prepared by electrospinning modified with semiconducting conjugated polymers aiming at the construction of BPV devices through the interfacing with photosynthetic microbes (biophotoanode) and hydrogenase (biophotocathode). BioH2Gen addresses recent progress in the field and tackles this topic by deploying a multidisciplinary approach to develop an innovative solar powered H2 production platform. The structure, charge transfer kinetics, and band-gap design of new flexible photoelectrodes will improve biotic-abiotic interactions for charge transfer. Finally, a tandem BPV assembly and its incorporation into a photoelectrochemical cell architecture will be carried out, aiming at high solar-to-hydrogen efficiencies. The successful implementation of the research methodology will culminate in a sustainable alternative in BPV device development due to the lightweight, low-cost, and low-environmental impact of the materials employed in their construction.

Keywords: bioelectrochemistry,electrochemistry
Multifunctional Flat Quantum Sources (MultiFlaQS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 2417170.0
EU funding (EUR): 2417170.0
Participants: 2
Project status: SIGNED

MultiFlaQS aims to develop efficient multifunctional sources of quantum light, namely entangled photon pairs and triplets, and squeezed states, based on ‘flat’ platforms, i.e., ultrathin layers and metasurfaces. The advantages of flat quantum sources (FlaQS) include: (i) small footprint and integrability; (ii) ultrabroadband and ultrafast operation; (iii) the possibility to combine several functionalities in the same device. Unlike linear and nonlinear ‘flat’ optics, which were developing for almost two decades, FlaQS appeared only recently, and mainly included single-photon sources. A few years ago, also FlaQS of entangled photons emerged; however, their efficiency is low and the advantages of the ‘flat’ geometry are not fully used. Generation of multiphoton quantum states, such as squeezed or graph states, is still a challenge. Most importantly, multifunctional operation has not been demonstrated. MultiFlaQS will make a decisive new step in developing FlaQS, one of paramount importance for quantum photonic technology. The following objectives are set: - Efficient generation of two-photon states and squeezed states, and their use in quantum sensing; - First-time generation of three-photon states through a direct decay of one photon into three; - Implementation of multiple functionalities: generation of quantum states, their frequency conversion and quantum operations on them. To meet them, the applicant will combine her quantum optics and quantum information expertise, including pioneering steps in developing FlaQS, with recent ideas in nanofabrication design. As a result, engineering of quantum states of light will be brought to a principally new level. Apart from the compactness, integrability, and broadband operation, FlaQS will be multifunctional and combine generation of quantum states of light with their transformation and frequency conversion. They will enable quantum sensing with subwavelength spatial resolution and subcycle temporal resolution.

Keywords: entangled photons,squeezed light,spontaneous parametric down conversion,metasurfaces,subwavelength nonlinear layers,flat optics,liquid crystal
Radical and Radical-Polar Crossover Logic in Terpenoid Synthesis (RadCrossSyn)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-05-01
End date: 2027-04-30
Duration (months): 60.0
Total project cost (EUR): 1987059.0
EU funding (EUR): 1987059.0
Participants: 1
Project status: SIGNED

The synthesis of complex natural products has shaped the field of organic chemistry, with translational applications spreading further into medicinal, agrochemical, and material sciences. As the largest class of natural products, terpenoids play a variety of roles in mediating antagonistic and beneficial interactions macroscopically, i.e., among organisms, and microscopically, i.e., on a (sub)cellular level. They defend many species of plants, animals, and microorganisms against predators, pathogens, and competitors, and they are involved in conveying messages within these organisms. Facilitating and streamlining the access to the most complex terpenoids, heavily rearranged and highly oxidized triterpenoids, requires an understanding of Nature’s ways to biosynthesize these structures, i.e., of their biogenesis. Biomimetic synthesis can only then provide routes which outrival classical retrosynthetic planning. In the absence of a plausible biogenesis proposal, this strategy is not accessible, though. So far, biogenesis proposals have, in lieu of validated intermediates and enzymes, followed the paradigm of polar mechanisms and evoked standard textbook reactions involving ionic intermediates to account for skeletal rearrangements. The aim of this project is to disprove this paradigm and cross this perceived limit of reactivity. Thus, we will here provide chemical proof that terpenoid biogenesis is not sufficiently explained by polar mechanisms, but rather is an intricate interplay of radical and polar reactivity. The border we attempt to cross is the one between two very different chemical entities: radicals and ions. Development of radical-polar crossover logic will evolve robust and selective routes to access drugable triterpenoid natural products modulating the immune system, targeting cancer, and combating pathogens. Added value comes from the involvement of modern photoredox catalysis strategies to initiate radical-polar crossover cascades in sustainable fashion.

Keywords: natural product synthesis,biomimetic synthesis
3D topological states in solid and soft ferroelectric materials (3D-TOPO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France,Slovenia,Spain,Argentina,United States
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2026-02-01
End date: 2030-01-31
Duration (months): 48.0
Total project cost (EUR): 1117230.0
EU funding (EUR): 1117230.0
Participants: 5
Project status: SIGNED

The 3D-TOPO project uncovers novel topological states in solid and soft ferroelectric materials, exploring their intricate polarization structures and interactions in confined geometries. By combining advanced experimental techniques with cutting-edge theoretical models, the project seeks to create a complete 3D map of these topological states at the micro- and nanoscale. Focusing on ferroelectric nanoparticles, nanodots, nanorods, and twisted bilayers, as well as confined nematic ferroelectric liquid crystals, 3D-TOPO examines topological states like vortices, helicoidal structures, and Hopfions, revealing the innovative manipulation methods by them. A key innovation of this project lies in its groundbreaking integration of solid and soft ferroelectrics to investigate topological excitations. This approach has not been previously explored in this context. The project employs a novel methodology for 3D reconstruction of polarization topology, allowing for a more comprehensive understanding of these materials. The project pioneers the technology of switchable chirality in ferroelectric nanostructures, offering great potential for applications in fields such as optoelectronics and nanophotonics. This initiative will foster a deeper understanding of fundamental material science through interdisciplinary collaboration while opening pathways for technological advancements in fields ranging from non-binary computing circuits to optoelectronics and bio-medicine. The consortium includes recognized institutions, the University of Picardie (UPJV, France), the Institute of Catalan Nanoscience and Nanotechnology (ICN2, Spain), the Jožef Stefan Institute (JSI, Slovenia), the National Scientific and Technical Research Council of Argentina (CONICET, Argentina), Kent State University (KSU, USA), ensuring a robust international and interdisciplinary approach.

Keywords: ferroelectrics,liquid crystals,topological states
Identifying Atherosclerotic Plaques at Risk: A Microstructure-based Biomechanistic Approach (MicroMechAthero)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 1879625.0
EU funding (EUR): 1879625.0
Participants: 1
Project status: SIGNED

Atherosclerotic plaque rupture in arteries is the primary cause of cardiovascular events such as heart infarct and stroke, which are responsible for 45% of deaths in Europe. Plaque rupture is a mechanical event, where the collagenous plaque tissue fails to withstand blood pressure loading. Identifying plaques at high risk of rupture is the key to prevent these fatal events. However, the current risk assessment strategy fails to achieve this as it lacks mechanistic insights into tissue failure. To address this unmet, urgent clinical need, I propose a paradigm shift to a biomechanistic risk assessment concept. I will achieve this with MicroMechAthero project, by revealing plaque failure mechanisms and developing a clinically applicable computational risk assessment framework. MicroMechAthero will combine ex-vivo, in-silico, and in-vivo research. Ex-vivo mechanical failure tests on post-mortem human plaque samples will involve tissue's collagen architecture imaging with recently developed polarization-sensitive optical coherence tomography and full-field, local, 3D tissue deformation measurements with digital volume correlation technique. This frontier opto-mechanical approach will revolutionize soft tissue testing and coupled with the virtual fields method, will provide unprecedented data for local, heterogeneous (hyper)elastic and failure properties of fibrous plaque tissue, linked to the underlying collagen network. Furthermore, a microstructure-based, in-silico tissue failure framework will be developed, using eXtended Finite Element Modeling technique, for plaque-specific risk prediction. This computational framework will be validated and tested for its clinical potential in an in-vivo patient study. Overall, MicroMechAthero will provide a ground-breaking advance in our understanding of plaque rupture and develop a biomechanistic in-silico framework for patient-specific in-vivo risk analysis, leading to revolutionary changes in cardiovascular medicine.

Keywords: biomechanics,cardiovascular,arteries,finite element modeling,experimental mechanics
She Sense: an accurate and non-invasive test that enables simpler, earlier and more cost-effective diagnosis of patients with endometriosis (Endosolve)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Ireland
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2499166.25
EU funding (EUR): 2499166.0
Participants: 1
Project status: SIGNED

Endometriosis is a chronic inflammatory disease defined as the presence of endometrium-like tissue outside the uterus. Establishment and growth of such endometriotic tissue is estrogen-dependent, thus it is mostly found in women of reproductive age. It is estimated that currently at least 190 million women and adolescent girls worldwide are affected by the disease during reproductive age although some women may suffer beyond menopause She Sense is an accurate and non-invasive test that enables simpler, earlier and more cost-effective diagnosis of patients with endometriosis Project scope: Experimental proof of principle for the novel digital biomarker has been demonstrated using early generation prototypes for research purposes in a pre-clinical model and exploratory human volunteer study. Sision Medical seeks to mature this technology and validate it’s use as a clinically acceptable diagnostic test. Therefore, the scope of this project will focus on the advancement of the She Sense test to investor readiness by; • Further refinement of the signal processing to optimise the digital biomarker performance • Validation of the biomarker in a clinical setting • Development of a sustainable business case and business model towards commercialisation The end point of the project is the compilation and evaluation of data obtained in a prospective clinical study. EIC funding will enable Sision Medical to enhance the technology efficacy and validation in a clinical setting. This will pave the path for larger studies which will demonstrate clinically acceptable sensitivity and specificity of the She Sense diagnostic test.

Keywords: endometriosis,diagnostic,digital biomarker,
Help Me Grow: Artificial Cognitive Development via Human-Agent Interactions Supported by New Interactive, Intrinsically Motivated Program Synthesis Methods. (INTERACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2026-08-31
Duration (months): 47.0
Total project cost (EUR): 276681.6
EU funding (EUR): 276681.6
Participants: 2
Project status: SIGNED

Building machines that interact with their world, discover interesting interactions and learn open-ended repertoires of skills is a long-standing goal in AI. This project aims at tackling the limits of current AI systems by building on three families of methods: Bayesian program induction, intrinsically motivated learning and human-machine linguistic interactions. It targets three objectives: 1) building autonomous agents that learn to generate programs to solve problems with occasional human guidance; 2) studying linguistic interactions between humans and machines via web-based experiments (e.g. properties of human guidance, its impact on learning, human subjective evaluations); and 3) scaling the approach to the generation of constructions in Minecraft, guided by real players. The researcher will collaborate with scientific pioneers and experts in the key fields and methods supporting the project. This includes supervisors Joshua Tenenbaum (program synthesis, MIT) and Pierre-Yves Oudeyer (autonomous learning, Inria); diverse collaborators, and an advisory board composed of an entrepreneur and leading scientists in developmental psychology and human-robot interactions. The 3rd objective will be pursued via a secondment with Thomas Wolf (CSO) at HuggingFace, a world-leading company in the open source development of natural language processing methods and their transfer to the industry. By enabling users to participate in the training of artificial agents, the project aims to open research avenues for more interpretable, performant and adaptive AI systems. This will result in scientific (e.g. interactive program synthesis approaches), societal (e.g. democratized AI training) and economic impacts (e.g. adaptive AI assistants). The dissemination, communication and exploitation plans support these objectives by targeting scientific (AI, cognitive science), industrial (video games, smart homes) and larger communities (gamers, software engineers, large public).
European Clinical Research Alliance on Infectious Diseases - PRIMary care adaptive platform trial for pandemics and Epidemics (ECRAID-Prime)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Other health destinations
Action type: Research and Innovation actions
Countries involved: United Kingdom,Belgium,France,Netherlands,Norway
Call: Cohorts united against COVID-19 variants of concern (HORIZON-HLTH-2021-CORONA-01, 2021)
Start date: 2021-12-01
End date: 2026-11-30
Duration (months): 60.0
Total project cost (EUR): 9998517.5
EU funding (EUR): 9998517.5
Participants: 6
Project status: SIGNED

European citizens affected by COVID-19 have been well-served by landmark clinical trials in hospitals that have found treatments that save many lives. However, there are fewer opportunities for people in the community to contribute to the urgent mission of finding treatments that speed recovery, and reduce the need for hospital admission in the first place. Evidence-based therapeutics for use in primary care have the potential for considerable reach and impact on individual suffering and functioning, as well as on the sustainability of health services. ECRAID-Prime, a European Adaptive Platform Trial (APT) of therapeutics for patients with COVID-19 and potentially COVID-like illness in primary care will build on many years of EU investment in infrastructure for primary care trials and a mature primary care research network that has pioneered novel, efficient, platform clinical trial designs. In the winter of 2022/23, respiratory viruses will be co-circulating and disease aetiology can’t be distinguished solely on clinical grounds. Treatments with potentially broad antiviral activity will be most beneficial if started early in the disease trajectory. For those treatments patients with syndromic COVID-like-illness might be included. ECRAID-Prime, with a focus on early phase studies of safety and efficacy of exciting candidate treatments for COVID-19 and COVID-like illness will be rapidly set up. Its goal is to test at least four candidate treatments, identifying suitability for inclusion in the next phases of research, and so leading to critical additions to the primary care therapeutic armamentarium against COVID-19 and COVID-like illness. ECRAID-Prime will additionally help complete the vison for a lasting, integrated, comprehensive and sustainable European clinical research preparedness and response capacity, Ecraid, that will provide a full, integrated suite of international priority clinical trials in intensive care units, hospital wards, and now in primary care as well.

Keywords: adaptive platform trials,early phase trials,epidemic,pandemic,covid 19,primary care
Superconducting qubits with 1 second coherence time using rotation codes (Q-CIRC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-08-01
End date: 2027-07-31
Duration (months): 60.0
Total project cost (EUR): 2275797.5
EU funding (EUR): 2275797.5
Participants: 1
Project status: SIGNED

Quantum computers use highly entangled qubits to achieve their exceptional computational power. However, the qubits also easily entangle with their environment, leading to errors. Future quantum computers can be protected against such errors by encoding each logical qubit redundantly in thousands of physical qubits. This daunting overhead can be reduced exponentially by improving the quality of the physical qubits. We can also replace the two-level physical qubits with cavities, which are described by continuous variables. This built-in redundancy can further reduce the overhead for fault-tolerant quantum computation. In this proposal, I aim to develop a qubit based on superconducting cavities with a coherence time of 1 second - three orders of magnitude higher than the current state of the art. I will achieve this goal by tackling the problem of errors in quantum computers on three fronts. The first front is developing a qubit with suppressed intrinsic loss mechanisms by harnessing recent developments in cavities for particle accelerators. The second is using quantum control to mitigate the effect of dominant error mechanisms. In the final front, we will develop and implement bosonic rotation codes, a novel blueprint for quantum error correction tailored to the error structure of the cavity qubit. These codes are unique in that they treat photon loss errors and phase noise errors on equal footing. My proposal requires a radical rethinking of the cavity design, its interaction with quantum circuits, and how quantum information is encoded and manipulated. It combines advances in quantum information science, superconductivity, and materials science. Beyond providing a novel approach to quantum computing, the proposal will impact a broad range of fields ranging from quantum-enhanced sensing to the simulation of photochemical reactions.

Keywords: bosonic qubits,rotation codes,schrodinger cat code,quantum error correction,teleportation,superconducting circuits,decoherence,fault tolerance,superconducting resonators,bosonic codes,quantum computation,transmons,phase estimation,superconducting cavities,quantum optics,circuit qed