Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reliability and effectiveness of integrated alternative water resources management for regional climate change adaptation (RECREATE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Innovation actions
Countries involved: Spain,Germany,Netherlands,Greece,Denmark
Call: Improve the reliability and effectiveness of alternative water resources supply systems and technologies (HORIZON-CL6-2023-CLIMATE-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 3437782.5
EU funding (EUR): 3392557.5
Participants: 11
Project status: SIGNED

RECREATE aims to improve the resilience of water supplies and protect the status of natural water resources by facilitating the assessment and inclusion of Alternative Water Resources (AWR) in water management planning for water scarce regions, and to increase awareness and acceptance of and trust in the fundamental role of AWR in climate change adaptation. RECREATE will produce an open access repository compiling knowledge and data on the cost-efficiency, environmental and health impact of different technological and water management alternatives. This repository will be encoded as an independent module into a Digital Decision Support Framework (RECREATE_WT) that, together with 3 additional modules covering climate change impact predictions, adaptation strategies to local context and a decision matrix will be used for co-creating adaptative pathways for water management. RECREATE_WT will compile and assess information on water availability and demand for a given region and organise knowledge on the performance of innovative treatment technologies. It will explicitly consider human health risks associated to potable use, local context (regulatory, cultural, spatial and socio-economical aspects) and water management strategies under different stress scenarios. The tool will provide a decision matrix for pathways creation,thus RECREATE_WT will act as a knowledge orchestrator and a decision theatre environment for co-designing water resource planning pathways RECREATE_WT will be demonstrated in 4 regional case studies (CS) covering different bio-regions (Mediterranean, Continental and Atlantic), and water contexts. CS will focus on the digitalization of the water cycle for integrated water management while demonstrating the cost-effectiveness reliability and safety of the use of new AWR. Full-scale or already available pilots from previous or already on-going projects will be used for RECREATE, optimizing the efforts and maximizing the impact reached.

Keywords: decision framework,knowledge orchestrator,co creation,adaptation pathways,alternative water resources,integrated water management
Enabling Fermionic Quantum Processing for Chemistry (FermiChem)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-03-01
End date: 2026-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The determination of ground states of many interacting fermions is a key application for future quantum computers with significant implications for the design of new materials and the prediction of reaction pathways in chemistry. Recently, we put forward the proposal Simulating Chemistry with Fermionic Optical Superlattices, establishing ultracold fermions in optical lattices as a promising computational platform for this task. This approach uses the hard-wired fermionic symmetries of ultracold atoms to potentially outperform spin-based quantum computers. The project FermiChem will turn this theoretical proposal into application and enable the first experimental demonstration of fermionic quantum processing with ultracold atoms. We will pursue three aims: (1) To generate fermionic quantum circuits for measuring arbitrary correlation functions for condensed matter; (2) To provide computer code to connect our UniRand fermionic quantum simulator to high-level programming languages and to execute such fermionic circuits in hardware; (3) To validate the design of a new type of tweezer architecture with dramatically enhanced motional coherence properties. Together, these innovations will establish a full stack for fermionic computing and translate our proposal for computation with fermionic circuits in superlattices into experiments with real-world applications. Our work will be embedded in a network of collaborations with academic and industry partners in order to guide the development of soft- and hardware towards fermionic quantum computation. FermiChem will point the way towards using fermionic quantum systems for industry-relevant problems in chemistry and material science.
INsect Clock Initial Training Experience (INCITE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia,Germany,Spain,Poland,Netherlands,Israel,France,Italy,Bulgaria,United Kingdom
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 3877120.8
EU funding (EUR): 3877120.8
Participants: 20
Project status: SIGNED

Organisms that inhabit the surface of the Earth have evolved an endogenous 24 hour clock that infiltrates every level of biological organisation from the molecular to the ecological. This biological timer is a critical adaptation to living on a rotating planet with predictable daily and seasonal cycles of light and dark, warmth and cold. The fruitfly Drosophila melanogaster has provided the model system by which the highly conserved genetic and molecular basis of animal rhythmicity was initially dissected, winning a Nobel Prize in 2017 to its discoverers. Our network INCITE (INsect Clock Initial Training Experience) will provide state-of-the-art doctoral training to doctoral candidates (DCs) in insect molecular chronobiology using a comparative approach in which the circadian clock will be studied from a variety of perspectives. These will include the recruitment of the clock for i) insect seasonal ‘hibernation’ or diapause, a critical life-history feature that has important implications for range expansion under global warming, ii) in pollination, ii) in pest control, iv) in optimising the development of insects mass-reared as a protein source for human/animal consumption – asustainable model for agriculture and vi) in fundamental circadian biology of the model insect, D. melanogaster. In addition to their research projects, DCs will be seconded to partners both academic and industrial within the network and be further exposed to a variety of successful well-defined and time-tested courses that supplement those already offered at their local institutions, and will enhance and develop their scientific, entrepreneurial and transferable skills. INCITE will generate highly-trained, mobile and employable graduates that will be welcomed both in academia and industry.

Keywords: circadian seasonal insects behaviour sleep metabolism food security protein mass production pests diapause sustainability climate change
Koopman-Operator-based Reinforcement Learning Control of Partial Differential Equations (KoOpeRaDE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499000.0
EU funding (EUR): 1499000.0
Participants: 1
Project status: SIGNED

An unprecedented energy crisis is looming over us. In order to transition to a greener and more energy-efficient society, existing technologies need to be improved and novel techniques such as nuclear fusion developed. This requires the stabilization of aerodynamics, heat transfer or combustion and fusion processes and thus, the development of efficient control strategies for large-scale dynamical systems. In recent years, reinforcement learning (RL) has emerged as a highly promising data-driven technique. Unfortunately, we cannot trust RL to handle our most important and complex systems, since the resulting controllers do not possess performance guarantees. Certifiable RL approaches such as linear or kernel methods tend to scale poorly, such that their applicability is limited to toy examples. In contrast to other application areas, this is a complete show-stopper for safety-critical engineering. Moreover, the training is extremely data hungry and costly, due to which RL itself contributes to the energy crisis. The vision of this project is to develop new foundational methods to equip RL controllers for large-scale engineering systems with performance guarantees by exploiting system knowledge and systematically reducing the complexity. To achieve this, I will target three major breakthroughs, consisting of (A) global linearization of the dynamics via the Koopman operator framework, (B) the extension of certified Q-learning to continuous action spaces via control quantization, and (C) the detection and exploitation of symmetries in the system dynamics. The project requires significant joint advancements in several challenging areas such as control, approximation theory and machine learning. In the case of success, the resulting controllers will provide a massive advancement of RL towards safety-critical engineering applications and significantly contribute to the challenge of meeting the future energy demands of our society.

Keywords: reinforcement learning,koopman operator,partial differential equations
Disrupted Reproduction of Riparian Predators in Polluted Environments (PIPER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Slovenia,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-12
End date: 2028-01-11
Duration (months): 24.0
Total project cost (EUR): 198557.52
EU funding (EUR): 198557.52
Participants: 2
Project status: SIGNED

The global decline of arthropod populations threatens biodiversity, ecosystem services, and food webs, with pesticides as a major driver. Arthropods are crucial for pollination, decomposition, and as prey for vertebrates. This decline, linked to intensive agriculture, affects over 74% of the world’s agricultural land with pesticide contamination. Despite EU regulations, pesticide pollution impacts aquatic and terrestrial ecosystems. Current risk assessments focus on survival, overlooking sub-lethal effects that can disrupt physiology and behavior affecting fitness and population viability. This project investigates the sub-lethal effects of pesticide exposure on the fitness of riparian Tetragnatha spiders, which are key predators in riparian ecosystems. These spiders feed on aquatic insects and thereby transfer pesticides to terrestrial environments. Despite their ecological importance, the impact of pesticides on their reproduction remains poorly understood. I will evaluate how sub-lethal pesticide exposure affects fitness-related traits, including sperm quality, oocyte development, and reproductive behavior, addressing gaps in ecotoxicological assessments. I hypothesize that pesticide exposure will reduce sperm quantity and quality, cause DNA fragmentation, impair oocyte development, and disrupt mating behavior, leading to reduced fitness and population viability. The project combines laboratory and field experiments along the Mura River in Slovenia, an area with documented pesticide contamination. Field data will inform laboratory experiments where spiders are exposed to various pesticide concentrations through contaminated prey. We will assess reproductive parameters and behavioral changes to understand the broader implications of pesticide exposure. This interdisciplinary research will advance evolutionary ecotoxicology, enhance understanding of pesticide impacts on reproduction, and inform conservation strategies, aligning with EU environmental objectives.

Keywords: arachnology,ecotoxicology,sperm parameters,animal behaviour,environmental chemistry,reproductive biology
Enhancing Copernicus Security Services - EU governmental crisis management hub for forced population displacement (THEIA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Greece,Spain,Germany,Luxembourg,Slovenia,Austria,Poland,Cyprus,Belgium
Call: Copernicus for Security (HORIZON-CL4-2024-SPACE-01, 2024)
Start date: 2024-12-01
End date: 2027-05-31
Duration (months): 30.0
Total project cost (EUR): 5243505.85
EU funding (EUR): 3997608.45
Participants: 12
Project status: SIGNED

Addressing critical challenges such as population displacement due to conflicts, exacerbated by factors like climate change, extreme weather events, food shortages, and poverty, remains paramount. The implementation of THEIA, integrating data fusion, processing, and analysis, particularly leveraging Geospatial Artificial Intelligence (GeoAI) and Machine Learning, is poised to enhance the efficacy of existing services significantly. Through the amalgamation of multi-temporal data and diverse datasets, THEIA empowers better decision-making and adapts to evolving policy and user needs. This technological advancement, bolstered by GeoAI, augments detection capabilities and ensures timely access to crucial information, bridging the gap between capabilities and stringent security demands. By integrating non-space data and end-user intelligence, THEIA’s supply chains add value not only at the operational level but also at regional and local levels, facilitating improved coordination. Furthermore, THEIA catalyzes fostering EU-independent capabilities and technologies, thereby bolstering the European space ecosystem's consolidation and ensuring the sustainable coexistence of legacy and New-Space solutions. Its services cater to a wide array of end-users, including EU entities such as SatCen and Frontex, Member State Ministries of Defence, Intelligence Agencies, Police Forces, NATO, and potentially Extra-EU National and Supranational Entities such as the United Nations.

Keywords: copernicus security services css,forced population displacement,very high resolution vhr,radio frequency rf,machine learning ml,platform
Imaging fear of painful touch: unraveling relationships between neural correlates of pain-related fear, somatosensory neuroplasticity, and sensory impairments in the context of chronic pain. (FABrIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-07-01
End date: 2026-04-30
Duration (months): 34.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

Chronic pain affects > 20% of people worldwide leading to enormous personal suffering and economic burden. A key factor contributing to chronic pain disability that thus far has been neglected is fear of painful touch - a core symptom in people with complex regional pain syndrome (CRPS). FABrIC (FeAr of painful touch in the BraIn in Chronic pain) is a functional Magnetic Resonance Imaging (fMRI) study using a novel tactile fear conditioning paradigm. I will examine the neural correlates of acquisition, generalization and extinction of fear of painful touch and interrelationships with somatosensory neuroplasticity, and sensory impairments in individuals with CRPS compared to healthy controls. Also, I will investigate how individual differences in vulnerability and resilience factors can modulate fear learning and how they affect pain-related outcomes. This MSCA project is groundbreaking and can yield novel insights in hypothesized intertwined underlying neural mechanisms of pain-related fear and relations with symptoms. I will uniquely and necessarily bridge the gap between different disciplines and pain researchers from physiotherapy, neuroscience, and psychology fields studying the same complex chronic pain disorder. Persons with CRPS endorsed the relevance of this project, which provides opportunities to alleviate the CRPS stigma and improve treatments based on newly gained insights. Maastricht University and the interdisciplinary outstanding research groups are ideal to perform this fellowship. The host developed and pioneered the tactile fear conditioning paradigm. This fellowship will provide the exceptional chance to synergistically combine my expertise of chronic pain and quantitative sensory testing with neuroscientific, neuroimaging, and threat-safety-learning expertise at the host, thereby crucially contributing to the establishment of my own independent chronic pain-brain research line, my career development and sustainable scientific collaborations.

Keywords: chronic pain,complex regional pain syndrome,functional magnetic resonance imaging,pain related fear,fear conditioning,associative learning,quantitative sensory testing
Exploiting Microbial Glycomimetics to Fight Antimicrobial Resistance (Glyco-Biotic)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Antimicrobial resistance (AMR) represents a significant health and economic challenge worldwide. Due to the fact that bacterial infections affect most people at some point in their lives, methods for specific recognition and targeting of bacteria are of key importance in developing approaches to counter the growth of AMR, where the discovery of novel antibiotics represents a global challenge in urinary tract infections (UTI). Progress in bioorganic synthesis has provided access to knowledge of the interactions between receptors (lectins) and specific carbohydrate on the outer membrane of bacteria. Cell surface carboAntimicrobial resistance (AMR) represents a significant health and economic challenge worldwide, where the discovery of novel antibiotics represents a global challenge in urinary tract infections (UTI). Progress in bioorganic synthesis has provided access to knowledge of the interactions between receptors (lectins) and specific carbohydrate on the outer membrane of bacteria. It is commonly accepted that this process requires an exquisite carbohydrate specificity of bacterial surface lectins and offer an opportunity to develop very selective probes that could target specific bacteria by the development of glycan mimics as potential drug candidates. Interestingly, some bacterial strains of E. coli are specific for galabiose. In order to design a drug candidate, it will be synthesized various glycomimetics with a common core of galabiose, which will be conjugated with a fluorescence probe to evaluate their binding affinity. Our hypothesis in this project resolves around the generation of a new class of antibiotics through the combination of known antibiotic drugs with the lead glycomimetics and allowing the drug delivery to the desired location. This project aims to test both aspects of the discovery of new antibiotics employing bioorganic approach based on the design, synthesis, diagnostic assays and drug delivery analysis of appropriate molecular models.

Keywords: carbohydrate chemistry,glycomimetics,multivalency,glyco probes,antimicrobial resistance
BIOdegradable delivery systems for plant pathogens control of horticultural crops through BIo-actiVE agents (BioBIVE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Spain,Norway,Netherlands,Italy,Germany,France
Call: Advanced (nano and bio-based) materials for sustainable agriculture (RIA) (HORIZON-CL4-2023-RESILIENCE-01-TWO-STAGE, 2023)
Start date: 2024-06-01
End date: 2028-05-31
Duration (months): 48.0
Total project cost (EUR): 6851903.0
EU funding (EUR): 6851903.0
Participants: 16
Project status: SIGNED

The BioBIVE Consortium is a multidisciplinary 16 members group of universities, research centres and SMEs from 6 different European countries aimed to achieve, as main objective: “the development of bio-based platforms to allow the controlled release of bio-active agents able to control the plant pathogens of horticultural crops helping to decrease the use of chemical pesticides”. The general objective is based on three different bio-based release platforms (bio-plastic mulch, biochar and sprayable mulch) and three bio-active agents (basic substances, microorganisms and marine phenolic compounds),which will be the starting point to achieve the final best formulation. The functionality of these bio-based delivery systems that use substances from natural sources against crop pathogens instead of chemical pesticides must be evaluated in laboratory, greenhouse and environmental conditions, using diverse cropping systems (e.g., carrots, strawberries, tomatoes) and techniques, which are part of the BioBIVE Partners expertise.

Keywords: mulch,biochar,basic substances,crop pathogens,sprayed mulch