Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Contributions of Prosodic and Lexical Cues to the Decoding of Phonetic Information from Speech (DecodPhones)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 2
Project status: SIGNED

A core aspect of language comprehension is the extraction of phonetic information from speech. This process is non-trivial due to the transient nature of phonetic segments and their overlapping presence in the acoustic signal. We aim to gain a deeper understanding of this complex process in the context of dyslexia. Individuals with this reading impairment have been found to process two aspects of speech differently from typical readers: they have difficulty extracting individual phonemes from words, and they show signs of imprecise cortical tracking of the speech envelope, an important correlate of speech prosody. However, it is unclear how exactly imprecise tracking of speech leads to phoneme-level deficits. Moreover, despite these deficits, natural speech comprehension in dyslexia remains intact, suggesting that compensation may take place. We address these gaps by applying state-of-the-art phonetic decoding analyses in dyslexia for the first time while varying prosodic and lexical cues within the speech signal. A novel analytical approach will reveal how listeners with and without dyslexia track phonetic segments over time, retain their correct order, and decode them into distinct phonetic representations. Cortical responses to phonetic segments will be tracked in natural speech, in synthesised speech with impoverished prosodic cues, and in meaningless pseudospeech (Jabberwocky) while MEG data are recorded. Comparing the neural dynamics of phonetic decoding in natural speech to speech with impoverished prosodic information will show to what extent prosodic cues facilitate decoding of fine-grained phonetic information. Comparing natural speech to pseudospeech will reveal whether poor phonetic decoding can be compensated with top-down information. The project will provide a better understanding of how phonetic information is extracted from speech and how this may relate to the persistent deficits in dyslexia, with important implications for theory and remediation.

Keywords: speech processing,phonetic decoding,dyslexia,phonology,prosody,meg
High-throughput discovery of degrons encoded by posttranslational modifications (Degron Miner)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 328835.31
EU funding (EUR): 230184.72
Participants: 1
Project status: SIGNED

The proteins of a cell are constantly turned over to adapt to changing environments or to eliminate damaged protein species. 80% of protein degradation is mediated via the ubiquitin-proteasome system (UPS). Specificity of the UPS is conveyed by E3 ubiquitin ligases (E3s), which transfer ubiquitin chains onto substrates to mark them for proteasomal degradation. E3s recognize their substrates via motifs termed degrons. Identifying degrons of all E3s would boost our understanding of proteostasis and would help designing pharmacologic strategies to modulate E3 activity. However, the “degron logic” of most of the >600 E3s encoded in the human genome remains elusive. This gap in our understanding of E3-degron relationships is related to the fact that degrons can be encoded by chemical modifications/posttranslational modifications (PTMs), which are not amenable to previously developed high-throughput degron discovery approaches via functional genomics. Here, we propose the Degron Miner platform as a high-throughput approach to systematically investigate the impact of PTMs on target protein stability. To this end, we will generate a 9000-member DegTag library consisting of modified peptides linked to a ligand that binds a nano-luciferase-tagged target protein. This library can be screened in a high-throughput fashion in live cells to select DegTags that efficiently degrade the target protein. To unravel the underlying mechanism and match E3s to the identified PTM-degron, I will employ FACS-based CRISPR/Cas9-KO screens and proteomics-based interactomics approaches. Further, I will leverage the identified PTM-degrons in chemical biology and FACS-based CRISPR/Cas9-KO screens to identify the endogenous substrates of E3s and the mechanisms leading to PTM deposition. Ultimately, the Degron Miner platform will deorphanize E3-substrate relationships and biological pathways involved in the regulation of protein degradation and will additionally provide tools to modulate E3s.

Keywords: e3 ubiquitin ligase protacs molecular glues posttranslational modifications ptms
Bioelectricity and gene regulation interplay in embryonic development (ELECTROGENDEV)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

Turning a single cell into a complex organism is a key biological process usually studied through molecular signals that guide cell specialization and tissue development. Although chemical gradients and transcription factors have been extensively studied, recent research highlights the critical role that bioelectric signals play in embryonic patterning and gene regulation. These bioelectric signals are produced when charged ions flow through certain proteins, such ion channels and pumps, and pass through the cell membrane. Unfortunately, because these two disciplines are frequently investigated independently, the precise interaction between bioelectric signals and gene control throughout embryonic development remains substantially unknown. The objective of the ELECTROGENDEV project is to unite these two fields and present an exhaustive explanation of how gene regulation and bioelectricity work together to govern embryonic development in the ascidian Ciona intestinalis. Due to its quick growth and simple body plan, this marine invertebrate has become an invaluable model organism for researching the molecular underpinnings of early embryonic development. In this project, I will map the bioelectric landscape during ascidian embryogenesis using genetically encoded voltage indicators and ion sensors. Parallelly, I will study a variety of ion channels, which are responsible for establishing that bioelectric landscape, and determine which ones are co-expressed with important developmental genes. Integrating these findings will pinpoint important regulatory nodes in the development of embryos, which I will then modify pharmacologically or genetically to create a full model of how bioelectric signals interact with the genetic program during embryo development. The findings have the potential to lead to new uses of bioelectric signaling, allowing us to address crucial issues in developmental diseases, regenerative medicine, and cancer reprogramming.

Keywords: bioelectricity,ascidian,ciona,membrane potential,ion channel
eXploring futurE humaN thermal bIoclimate pAthways (XENIA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 217965.12
EU funding (EUR): 217965.12
Participants: 1
Project status: CLOSED

Xenia refers to the ancient Greek concept of hospitality. It is a traditionally established host-guest relationship rooted in reciprocity. Earth (the host) has served this institutionalized notion for millions of years providing inhabitable conditions to humans (the guests), and thus, allowing them to thrive. However, the human activities of recent centuries have violated the Xenia rules leading to the disruption of the Earth’s climate. As a consequence, the planet is becoming less hospitable. The global warming and the consequent intensification of weather and climate extremes induce severe impacts to humans, including losses of millions of lives. The most important threat is related to the thermal environment. Extreme heat in particular, is responsible for more premature deaths than any other natural disaster, especially in cities due to the urban overheating. Exposure to incompatible with human life heat conditions is expected to increase in the future as climate change escalates. Yet, there is a critical lack of robustness concerning the projections of future heat-health outcomes. This is primarily driven by the fact that both thermo-physiological and behavioral adaptation of humans to local climates is ignored. In order to address this significant gap in future climate impact assessments, the current project will eXplore futurE humaN thermal bIoclimate pAthways (XENIA), considering the physiological and behavioral responses of different groups of people with particular focus on the most vulnerable.

Keywords: human biometeorology extreme heat human thermal bioclimate human health diverse populations autonomous adaptation environmental epidemiology
Université Paris-Saclay Scientific Training And Research programme for the next generation of Physicists (UPSaclaySTAR-Phy)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: France,Spain,Germany,Portugal,Hungary,Denmark
Call: MSCA COFUND 2024 (HORIZON-MSCA-2024-COFUND-01, 2024)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 4624800.0
EU funding (EUR): 4624800.0
Participants: 27
Project status: SIGNED

We propose to set up an attractive postdoctoral programme - UPSaclaySTAR-Φ - incorporating a meticulously crafted mix of advanced, transferable scientific training and soft skills. Through two calls and a transparent, merit-based and fair selection process, we will recruit 41 postdoctoral fellows to join Université Paris-Saclay in France and its collaborating partners. The scope of the programme spans the full spectrum of the diverse physics research carried out at Université Paris-Saclay, from fundamental to applied. It includes theory, modelling, simulation, and instrumentation, from lab experiments to investigations on large-scale infrastructures or in space. Organised around 3 key areas: Physics of Waves & Matter, Physics of the 2 Infinities, and Astrophysics, the programme also addresses socio-economic issues at the core of European priorities like energy, health, the environment, and climate. Fellows will benefit from an outstanding instrumental scientific milieu, spanning from large-scale facilities to smaller platforms, with privileged access to major international physics infrastructures. Technological and applied activities, and interdisciplinary interfaces with broad societal impact, leverage a vast network of industrial collaborations. This is reinforced by the university strategic location within the Paris-Saclay public-private innovation hub, France’s largest, gathering 15% of French public and private R&D. Fellows will acquire new scientific and technical knowledge in a cutting-edge research programme, under excellent working conditions and exposure to recognised teams in academia or industry. Supervision, industrial mentoring, and training activities in research management, entrepreneurship, and for the acquisition of new soft skills will empower them to gain autonomy, skills, and recognition. They will be in a position to benefit in the longer term from a wide range of career opportunities in research and innovation backed by a robust network.

Keywords: quantum and soft matter physics,nanophysics,nuclear particle and astroparticle physics,astrophysics,cosmology,advanced technologies and instrumentation,physics of energy,health,and the environment
Building Outstanding Opportunities for Science and Talent (BOOST)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Bulgaria,Cyprus,Greece,Belgium,Italy,Bosnia and Herzegovina,Portugal,Romania,Spain
Call: ERA Talents (HORIZON-WIDERA-2024-TALENTS-03, 2024)
Start date: 2025-06-01
End date: 2028-11-30
Duration (months): 42.0
Total project cost (EUR): 2873750.0
EU funding (EUR): 2873750.0
Participants: 16
Project status: SIGNED

The BOOST project addresses the significant disparities in innovation capacity among the EU Widening Countries, primarily in Eastern Europe. Although these nations excel in academic research, they struggle to translate their achievements into commercially viable products and services. This gap negatively affects the social, financial, and environmental sustainability of these regions, limits economic growth, and exacerbates issues like brain drain and low career opportunities for researchers and innovators. BOOST aims to strengthen the R&I capabilities of Widening Countries by fostering collaboration between academic and non-academic sectors. It focuses on enhancing career opportunities and entrepreneurship by providing researchers with the skills needed to succeed in both academic and industrial settings. A key element is the creation of the BOOST Learning Environment, which will facilitate knowledge exchange and collaboration among organizations across Europe, giving access to a rich database of tools, resources, and learning modules. Central to the project is the implementation of the BOOST ERA Talents Scheme, which provides 12-month mobility opportunities for 60 researchers, improving their practical skills through placements in industry settings. The scheme also includes five tailored learning modules, and each participant will receive a Personal Career Development Plan to support long-term career advancement. The project ensures that at least 30% of mobility participants will be women or individuals from underrepresented groups, addressing the imbalance that persists in R&I fields. BOOST provides broad sectoral expertise through its consortium partners. By focusing on skill development, practical training, and cross-sector collaboration, the project will create a sustainable impact that extends beyond its duration, helping Widening Countries improve their R&I capabilities and compete on the global stage.
A Health Technology Assessment of a breakthrough technology in the early diagnosis of Osteoporosis and other bone related diseases. (NonInvasive Cortical Bone Microstructure Analysis)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-02-01
End date: 2026-05-31
Duration (months): 40.0
Total project cost (EUR): 3755018.75
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Osteoporosis accounts for more days in the hospital than breast cancer, heart attack, and diabetes, leading to huge healthcare costs. Despite this, bone mineral density (BMD), the current gold standard for diagnosis of osteoporosis is insufficient, and fails to detect 80% of people at risk of a fragility fracture. The Porous solution aims to replace BMD as the standard for osteoporosis diagnosis. Using mobile and harmless quantitative ultrasound technology with our patented intelligent algorithms, we can for the first time measure the cortical bone quality down to the microscopic pore level. This gives a multifactorial analysis of fracture risk that overcomes the weaknesses of BMD. Due to the use of mobile ultrasound systems, this solution can be used anywhere in or outside the hospital, such as primary care facilities. It creates the ability to use the technology for prevention via screening, and opens unprecedented possibilities for the early diagnosis of osteoporosis.

Keywords: cortical bone,quantitative analysis,osteoporosis,quantitative ultrasound,software,patented,breakthrough
Real-world evidence for decisions in diabetes (REDDIE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Austria,United Kingdom,Denmark,Germany,Italy,Sweden,Netherlands,United States,Croatia
Call: New methods for the effective use of real-world data and/or synthetic data in regulatory decision-making and/or in health technology assessment (HORIZON-HLTH-2022-TOOL-11, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 4813833.75
EU funding (EUR): 4788833.75
Participants: 16
Project status: SIGNED

Randomised controlled trials are the cornerstone of evidence-based medicine. However, the digitisation of real-world data (RWD) including data from devices, wearables, and electronic health records in large national registries provides opportunities to demonstrate efficacy and safety of innovative technologies including drugs, devices, diagnostics, and digital health. These data are particularly relevant to long-term conditions such as diabetes mellitus, where drugs, lifestyle interventions, and digital technologies often work together. To better utilise RWD in diabetes for regulatory decision making, a development of standards, guidance, and an assessment of the efficacy to effectiveness gap is needed. REDDIE (Real-World Evidence for Decisions in Diabetes) aims to explore how RWD can complement RCTs to improve efficacy, safety, and value for money of technologies to prevent and treat diabetes. The overall aim of REDDIE is to support the use of RWD in diabetes and health-related research, which will maximise Europe’s scientific expertise and know-how to benefit people with diabetes, resulting in safer, more efficient, and cost-effective interventions. We thus aim to engage with stakeholders such as regulatory and HTA authorities and co-develop evidentiary standards for the collection, assessment, and acceptability of RWD. We will then develop and validate state-of-the art modelling techniques using synthetic data derived from large national registries to better assess outcomes of interventions using RWD. We will use data from four large national registries to elucidate the gap between outcomes in RCTs and RWD studies, and understand the factors that affect this gap. Finally, we will test the ability of machine learning to facilitate the better use of RWD. REDDIE will generate standards for RWD use for the evaluation of medicines and other interventions by regulatory authorities and HTA bodies.

Keywords: real world data,diabetes mellitus,methodological standards,health regulatory bodies,health technology assessment
NEXT GENERATION VACCINES AGAINST GASTROINTESTINAL MUCOSAL PATHOGENS, USING HELICOBACTER PYLORI AS MODEL PATHOGEN (Vax2Muc)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Germany,Denmark,Portugal,Ireland,Czechia,Belgium,United Kingdom,Spain
Call: Vaccines 2.0 - developing the next generation of vaccines (HORIZON-HLTH-2022-DISEASE-06-two-stage, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 8219842.5
EU funding (EUR): 8219842.5
Participants: 10
Project status: SIGNED

To overcome antimicrobial resistance (AMR) compromising global public health, novel strategies to develop next generation vaccines against AMR pathogens are required. However, the development of effective vaccines is challenging for bacterial infections occurring at mucosal sites, in particular in the gastrointestinal (GI) tract. In this context, H. pylori is listed as high priority AMR pathogen and the most common chronic bacterial infection affecting half of the world’s population with a high risk to progress into gastric cancer. Previous failures in H. pylori vaccine development approaches suggest that induction of mucosal immunity is required for protection. Thus, Vax2Muc will develop a rational prophylactic lead candidate against H. pylori in a straight-forward manner and directly evaluate this candidate for safety and immunogenicity in a phase I clinical trial, serving as proof-of-concept for novel vaccine technologies developed in Vax2Muc. To induce long-term protective mucosal immune responses sustained by tissue resident memory T cells, we will apply our previously identified vaccine antigens, combined with potent adjuvants for a systemic prime, and implemented in an innovative oro-mucosal film for a mucosal pull. Vax2Muc will further advance GMP manufacturing, and investigate and progress novel vaccine technologies and strategies tailored for mucosal application. We will evaluate our lead candidate and alternative approaches in pre-clinical mouse and pig models to define meaningful correlates of immunity and protection, which are still lacking for most of GI/AMR infections. Thus, Vax2Muc will deliver (i) a prophylactic vaccine candidate against H. pylori as PoC, and (ii) a wealth of knowledge and technologies that can be translated into the clinical development pipeline and are broadly applicable for various GI/AMR mucosal pathogens to significantly benefit the challenging field of mucosal vaccination and finally reduce disease burden from AMR/GI diseases.

Keywords: mucosal vaccination helicobacter pylori adjuvants correlates of protection mucosal immune response tissue resident memory t cells antigens sublingual formulation antimicrobial resistance