Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Electrophilic Indoles for the Enantioselective Synthesis of Benzofuroindolines related to Diazonamide A (ELECTROINDOLE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2015-02-19
End date: 2017-02-18
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

The objectives of this project are the development of A new and efficient asymmetric oxidative coupling reaction between phenols and indoles for the synthesis of benzofuroindolines analogs of diazonamide A and the biological evaluation of a library of this family of compounds. The benzofuroindoline core is a unique motif found in the natural products diazonamide A, a very potent anti-cancer agent (<5 nM against various cell lines) which may have clinical utility for cancer therapy since it is as active as widespread used antimitotic drugs without their overt toxicity. Unfortunately, the known synthetic methods for the generation of the benzofuroindoline scaffold are not short, high yielding and enantioselective at the same time. Therefore, we aim to study and develop direct and general methods for the synthesis of this important pharmacophore. We desire to use as starting materials phenols and indoles that are the postulated biosynthetic precursors of the natural benzofuroindolines. To meet this goal, we propose an innovative strategy based on the scarsely known electrophilic character of the indole nucleus. We will particularly aim at the development of enantioselective catalytic reactions. After the development of suitable reactions for the synthesis of benzofuroindolines, we intend to create a library of analogs of diazonamide A that will be evaluated against different tumoral cell lines in order to discover simplified analogs which would be synthesized in few steps with retention of the clinical potential of diazonamide A. The research will be conducted at the Institut de Chimie Moléculaire et des Matériaux d’Orsay (ICMMO), Université Paris-Sud 11 by Raj Kumar Nandi under the responsability of Guillaume Vincent.

Keywords: diazonamide,benzofuroindoline,indole,electrophile,phenol,cross-coupling,iron trichloride,heterocycles,asymmetric synthesis,multistep synthesis,antitumoral
Photonic-plasmonic hybrid for optical switching and biosensing application (PHOTON-PLASMONHYB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

The main objective of this proposal is on exploring the synergy of the two cores of nanophotonics technologies, i.e., silicon photonics and plasmonics, which have been identified as one of the key competitiveness of European research and economic sectors. [The Leverage Effect of Photonics Technologies: the European Perspective. By European Commission] The project addresses hybrid structure composing of a silicon microring (MR) or microdonut (MD) resonator coupled with a plasmonic nanoantenna. The presence of the nanoantenna, with its controllable and enhanced local electromagnetic fields, will allow controlling the optical properties of MR or MD via near-field coupling, but which is achievable through far-field excitation. Many degrees of control over the optical property of the MR or MD are achievable via the polarisation state of the far-field source, and size, shape, orientation and placement of the nanoantenna with respect to the MR or MD. The underlying physics behind the photon-plasmon coupling will be investigated with an aim of achieving design rules for photonic-plasmonic hybrid structure. Furthermore, the proposed hybrid structure will be demonstrated for use as an optical switch and a biosensor. The generated research outcomes will be relevant to the EU in two main respects: first, they will help advance the fundamental knowledge concerning the physics behind the coupling between silicon photonic structure and plasmonic nanoantenna, which will strengthen the position of EU as the world’s leader in the field, towards making it the hub of scientific research and, second, the design has potential for intellectual property protection, thus, enhance EU’s industrial competitiveness by giving its an edge in the marketplace.

Keywords: che,plasmonics,nanoantenna,silicon photonics,microring resonator,microfluidic,optical switch,biosensor,chemical sensor
Cost and Energy Efficient Optical Access and Local Area Networks (CEEOALAN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 168794.4
EU funding (EUR): 168794.4
Participants: 1
Project status: CLOSED

The continuous growth of Internet traffic pushes hard for a cost and energy efficient upgrade of the bit rates in short reach Ethernet, next generation passive optical networks and inter data center links. The goal of this project is to identify and demonstrate cost and power efficient modulation formats for these scenarios. Preferred candidates are formats with high spectral efficiency, intensity modulation, and direct detection. The proposal looks into carrierless amplitude and phase (CAP) modulation, partial response signaling, and optical orthogonal frequency division multiplexing (OFDM). Optical OFDM leveraging advanced digital signal processing has shown great resilience to linear system effects such as fiber dispersion. CAP and partial response are emerging formats that potentially have lower cost and lower power consumption due to an analogue implementation, but have not yet been investigated for optical transmission in very great detail. The major objectives of this project include a theoretical analysis and fair comparison of the different formats on aspects of optical power budget, cost, and power dissipation to identify the optimum formats for the relevant applications; the digital implementation of one or two variants and measurements in the relevant scenarios, and the analogue implementation of CAP and/or partial response optical links. The theoretical work will be based on numerical simulation with input on the component costs from the host. The experimental work is based on the high speed digital/analogue equipment, the test setup, and related hands-on training provided by the host - ADVA Optical Networking. The project is strongly exposed to industry and involves inter-sector mobility, which enables the fellow to generate impact to a wide scope by implementing a number of world first high speed optical links with great commercialization potential, as well as to develop new skills/competencies through flexible training offered by the host.

Keywords: carrierless amplitude and phase modulation,partial response,optical ofdm,cost and energy efficiency,next generation passive optical network,high speed ethernet,inter data center networks.
From the Sun to stars - Interplay between dynamo and corona (DYNACOR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 161968.8
EU funding (EUR): 161968.8
Participants: 1
Project status: CLOSED

Most stars show strong magnetic fields on their surfaces and sustain a hot outer atmosphere, the corona. Two of the fundamental problems in stellar astrophysics are how the stars generate their magnetic field, and how they manage to heat the corona to temperatures of two million K, well in excess of the surface. I will address these problems by performing local and global numerical simulations. These include the stellar interior and an overlaying corona, which are evolved self-consistently by solving the magnetohydrodynamic equations using high performance computing. First results of such novel simulations show that the dynamo benefits substantially from the presence of a corona leading to a stronger amplification of the magnetic field inside the star and that the dynamo can drive dynamic events in the corona. For a more complete understanding of the coupled dynamo-corona system, further steps towards more realistic models have to be taken. The overall goal of the proposed project can be subdivided into three major parts: (1) understand fundamental properties of stellar dynamos using accurate mean-field models of the direct numerical simulations, (2) investigate the influence of the coronal envelope on stellar dynamos and stellar interiors, (3) determine the role of stellar dynamos for the formation and evolution of coronal structures. This study will have a major impact on the fundamental understanding of solar and stellar activity cycles, which is pivotal for interpretation of stellar observations. In particular this concerns the description of the solar and stellar dynamo processes, the formation of space-weather events and the coronal heating mechanisms. Modeling the exact relation between stellar parameters, dynamos in the interior and coronal properties will for the first time provide a clear interpretation of observable atmospheric quantities for a large range of stars, for example the relation of rotation rate and stellar X-ray luminosity.

Keywords: astrophysics,sun,stars,magnetohydrodynamics,magnetic field generation,corona,activity cycles,plasma physics,numerical simulation,high-performance computing
Stemming the rising tide: The protective role of saltmarshes (STORM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

Sea level rise and the associated flooding of coastal regions are predicted to lead to severe impacts in many European countries. It is recognised that coastal habitats will play a vital role in mitigating the effects of sea level rise, through increasing sediment accretion rates and thus surface elevation. In Europe, saltmarshes are the primary vegetated coastal habitat and are widely distributed along the European coastline. Both geological evidence from the Holocene, when sea levels rose quickly and significantly and models of contemporary sea level rise suggest that saltmarshes are able to keep pace with sea level rise when sediment supply is sufficient, thus protecting inland habitats from inundation. Saltmarshes have also been shown to be very effective at attenuating wave energy during storm surges. Vertical accretion rates in vegetated coastal habitats are the result of complex interactions between geomorphological (e.g. geological subsidence, sedimentation rates) and biological processes (e.g. root growth and organic matter accumulation and thus require a multidisciplinary research approach. Salt marsh growth and physiology can be an important driver of change in vertical accretion but the lack of data on biological processes, especially belowground, has been identified as a confounding factor for salt marsh models. This project is academically innovative, as it will simultaneously determine the role of biological processes (both above and below ground) and geomorphological processes in the overall changes to vertical accretion under different global change scenarios and incorporate those into existing salt marsh evolution and surface elevation models that predict the vulnerability of coastal areas to sea level rise.

Keywords: climate change,coastal zone management,plant ecophysiology,coastal wetlands,shoreline stabilization,surface elevation,eutrophication,elevated co2,sea level rise
An investigation of the impact of multi-platform media coverage of the 2012 London Paralympic Games and the 2015 Toronto Parapan American Games upon perceptions of disability (LONTOR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 299558.4
EU funding (EUR): 299558.4
Participants: 1
Project status: CLOSED

There is a paucity of research on the social legacy impacts of sporting mega-events, particularly disability sport events such as the Paralympic Games and the Parapan American Games. This research will adopt a comparative case study approach by comparing the multi-platform media coverage of the London 2012 Paralympic Games and the Toronto 2015 Parapan American Games two Games as a way to assess their potential impacts upon attitudes towards, and perceptions of, people with disabilities within the host city and nation. Both host cities have/had the aim of using the Games to help change perceptions of people with disabilities within their respective countries. The aim of this project is to use the findings to inform the approaches of other cities who host major sporting or cultural events of new ways to use the media to help reframe the traditional stigmatized framing of disability. The overall objectives are, therefore, i; a current analysis of the diverse elements that impact on attitudes towards disability, and legacy in the context of large disability sport events, ii; new data on the implications of hosting major disability sporting events and their impact upon attitudes towards, and perceptions of, disability, and iii; an analysis of the use of different media by interview subjects (TV, Newspapers, Social Media etc.) and their impact upon attitudes towards disability and the Games.

Keywords: paralympic games,disability sport,parapan american games,london 2012,toronto 2015,perceptions,attitudes,media,social media
Investigation of the Structural Stability and Integrity of Steel Foam Sandwich Panels (INSIST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-01-12
End date: 2017-01-11
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

INSIST is an experimental investigation on the structural integrity and stability of novel steel foam sandwich panels under monotonic and cyclic loading. The response of single density and graded properties cores are studies and the differences in the observed failure modes quantified. Furthermore the project explores the response of welded end-plates in steel foam sandwich panels and testing the strength and tolerance of the connection under static load and fatigue. Also for the first time a pilot corrosion test will take place in order to observe the failure propagation in fatigue within a corrosive environment. These tests are essential and will pave the way for the use of SFSPs in structural engineering applications. Moreover, the project seeks to explore biomimetic optimized applications for steel foam sandwich panels in the offshore and marine sector that can perform more than one function, such as weight, vibration damping and even provide data for structural health monitoring purposes. The overarching aim of this project is the training of the researcher in the field of experimental structural stability and integrity specific to novel functionally optimized components pertinent to offshore and marine engineering, at Cranfield University’s Department of Offshore, Process and Energy Engineering Structural Integrity Lab. The purpose of this fellowship will be to equip the researcher with the necessary skills to pursue independent experimental and computational research in structural integrity of offshore structures and other safety critical structures pertinent to the Energy industry which is an emerging industry in the Eastern Mediterranean and Cyprus, where the researcher’s home institution is located (Cyprus University of Technology), as well as an industry of critical importance for Europe’s Energy Security.

Keywords: experimental structural integrity,localized buckling,steel foam sandwich panels,biomimicry,4-point testing,fatigue,corrosion,functionally graded materials
Improving prediction of the triggering of bipolar disorder episodes by childbirth (POSTPARTUM BID)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-09-01
End date: 2017-08-31
Duration (months): 36.0
Total project cost (EUR): 282109.2
EU funding (EUR): 282109.2
Participants: 1
Project status: CLOSED

Bipolar disorder is a leading cause of disability and death in women of childbearing age and episodes of bipolar disorder immediately following childbirth are common and clinically important. With its discrete, identifiable trigger, bipolar disorder triggered by childbirth represents a unique opportunity for risk prediction modeling in psychiatry. Genetic variants have been robustly implicated in the susceptibility to bipolar disorder. Comprehensive approaches that integrate information on genetic susceptibility with clinical risk factors have been successfully applied to prediction modeling of many disorders and are needed in psychiatry. In this fellowship I plan to bring these techniques to psychiatry and to apply them to the prediction of episodes of bipolar disorder following childbirth. My primary goal is to develop clinically useful predictive models for episodes of bipolar disorder triggered by childbirth. I anticipate that the predictive models will help in individualizing risk assessment, and thus improve the identification of women at risk and the clinical outcomes. In addition, by helping to inform understanding of the interplay of risk factors in pathogenesis the work will contribute towards more focused and effective clinical management. This fellowship will build in two important ways on my PhD research in which I studied postpartum episodes in the large Cardiff bipolar disorder clinical datasets available at the time (N=2,032). First, I will develop and externally validate multivariable prediction models for postpartum bipolar disorder using very large international collaborative samples of over 20,000 individuals. Second, I will receive training in new areas of research that will include multidisciplinary approaches to postpartum mood disorders (in Chapel Hill, North Carolina, USA), biostatistics and bioinformatics (in Cardiff, Wales and Chapel Hill).

Keywords: bipolar disorder,postpartum psychosis,psychiatric genetics,risk prediction models
Economies of Uncertainty: Epistemological Perspectives on the Reform of the Metric System (PRESUME)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-07-01
End date: 2016-06-30
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

Metrology, the science of measurement and standardization, is today almost completely ignored by philosophers of science, although its impact on basic science, commerce, industry and daily life can hardly be overstated. Metrologists are responsible for the standardization of physical measurement in accordance with the International System of units (SI), colloquially known as the ‘metric system’. In 2011, the International Bureau of Weights and Measures called for a fundamental reform of the metric system, to be implemented by 2018. This reform will see the current standard kilogram – a platinum–iridium cylinder kept at a vault near Paris – retire from service, and four of the basic metric units (the kilogram, ampere, mole and Kelvin) redefined in terms of four fundamental constants of nature. The impending reform of the metric system provides a valuable and timely opportunity for the philosophical study of the concepts, goals and methods of metrology, and for the development of a comprehensive epistemology of standardization. These goals will be achieved by combining the tools of conceptual analysis together with informal interviews held at Europe’s three leading national standardization institutes (in the UK, France and Germany). The resulting insights will be employed to enhance the visibility and appreciation of metrology among scientists, humanities scholars and the general public through the organization of a series of public and academic events.

Keywords: philosophy of science,epistemology,sociology of science,measurement,standardization,expertise,knowledge sharing