Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Climate Positive Drying System for Coffee Industries using a highly disruptive Pyrolysis Technology (PYROTECH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

PYROTECH is based on a highly disruptive pyrolysis technology as a heating source for drying coffee cherries and makes it possible to produce biochar (a fertilizer used in coffee agriculture). It will displace the market’s “dry methods” for processing coffee, which involves sun drying or the use of heat coming from a conventional burner, which produces heavy smoke, environmental pollution, and lung diseases as well as negatively affecting the quality of coffee cherries quality and resulting in black colouring. PYROTECH is four to ten times cheaper than other pyrolysis systems. It will generate more than 6,5 million euros of additional income for European coffee companies and will eliminate more than 18.000 tonnes of C02 emissions in the first three years due to the carbon sequestration potential of coffee husk used and biochar produced. Currently, more than 9,5 million tonnes of green coffee beans are processed annually, from which 4,8 million tonnes are produced using the dry method. Taking into account the market size, market distribution and current interest of our potential clients, PYROTECH will cover after five years of commercialization, 18% of the total amount of pyrolysis machines needed to dry the coffee cherries. Coffee buyers will require farmers to use PYROTECH as a result of the increased quality of the product, the decrease in the selling price and the improved health and safety conditions.

Keywords: coffee drying,biochar,pyrolisis,circular economy
Brain metastases: Deciphering tumor-stroma interactions in three dimensions for the rational design of nanomedicines (3DBrainStrom)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Israel
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-04-01
End date: 2025-03-31
Duration (months): 72.0
Total project cost (EUR): 2353125.0
EU funding (EUR): 2353125.0
Participants: 1
Project status: SIGNED

Brain metastases represent a major therapeutic challenge. Despite significant breakthroughs in targeted therapies, survival rates of patients with brain metastases remain poor. Nowadays, discovery, development and evaluation of new therapies are performed on human cancer cells grown in 2D on rigid plastic plates followed by in vivo testing in immunodeficient mice. These experimental settings are lacking and constitute a fundamental hurdle for the translation of preclinical discoveries into clinical practice. We propose to establish 3D-printed models of brain metastases (Aim 1), which include brain extracellular matrix, stroma and serum containing immune cells flowing in functional tumor vessels. Our unique models better capture the clinical physio-mechanical tissue properties, signaling pathways, hemodynamics and drug responsiveness. Using our 3D-printed models, we aim to develop two new fronts for identifying novel clinically-relevant molecular drivers (Aim 2) followed by the development of precision nanomedicines (Aim 3). We will exploit our vast experience in anticancer nanomedicines to design three therapeutic approaches that target various cellular compartments involved in brain metastases: 1) Prevention of brain metastatic colonization using targeted nano-vaccines, which elicit antitumor immune response; 2) Intervention of tumor-brain stroma cells crosstalk when brain micrometastases establish; 3) Regression of macrometastatic disease by selectively targeting tumor cells. These approaches will materialize using our libraries of polymeric nanocarriers that selectively accumulate in tumors. This project will result in a paradigm shift by generating new preclinical cancer models that will bridge the translational gap in cancer therapeutics. The insights and tumor-stroma-targeted nanomedicines developed here will pave the way for prediction of patient outcome, revolutionizing our perception of tumor modelling and consequently the way we prevent and treat cancer.

Keywords: 3d bio printing,brain metastases,melanoma,breast cancer,lung cancer,tumor microenvironment,nanomedicines
Drug-Free Antibacterial Hybrid Biopolymers for Medical Applications (HyMedPoly)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Italy,Germany,Ireland,United Kingdom,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EID) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3918054.96
EU funding (EUR): 3918054.96
Participants: 8
Project status: CLOSED

There is a general consensus that biomedical polymers of natural and synthetic origin should and will play a very important role in the development of new therapeutic strategies to treat diseases. Due to resistance of bacteria to drugs, infection has become one of the toughest problems in the medical world as there are hardly any effective antibiotics left in the fight against many pathogens. This project aims to develop new therapies through a new combination of technology (a) development of new hybrid polymers with antibacterial functionality,(b) introduction of inhibitors that can permanently deactivate bacteriological proteases and (c) new formulations of bioactive ceramics and glasses that have specific charge potential to prevent bacterial growth. The challenge is to develop new medical polymers that have an intrinsic antibacterial functionality to achieve clinical effectiveness in the field. To develop the challenge to practical medical solutions, a new generation of industrial professionals is needed. They should have a solid multidisciplinary background complemented by the required academic and industrial experiences. The objective of this network is to train young PhD researchers to fill this demand in the strategic area of drug-free antibacterial hybrid biomedical polymers. This EID programme will achieve this by a joint training programme of world class academic and industrial institutes who will provide hands-on training in state of the art research projects related to key fundamental issues that determine the future new therapies of antibacterial biomaterials. The goal is to develop professionals that will play a pivotal role in pushing forward this challenging and knowledge-intense field for the coming decades to benefit the European economy, bring state-of-the-art technology to industry with advanced products for hospitals and personal health care and contribute to the development of therapeutic strategies to improve the quality of life.

Keywords: polyurethanes,polylactide,polyglycolide,polyhydroxyalkanoatesm polyglocide,antibacteria,bioceramic,bioactive glass,hybrid polymers
Cost-effective high speed Production for Fasteners in Titanium for the automotive industry (PROFIT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-07-01
End date: 2018-10-31
Duration (months): 28.0
Total project cost (EUR): 2567500.0
EU funding (EUR): 1797250.0
Participants: 1
Project status: CLOSED

Starting originally in 1950 with the manufacturing of titanium components for motorsports, we, POGGIPOLINI became official suppliers for the Formula One (Ferrari and McLaren) in the 80s, the aerospace industry in the 90s (Agusta helicopters) and finally the automotive industry in 2004 (Ferrari, Lamborghini, Bugatti, McLaren, Porsche and Fiat). Following a change in F1 technical regulations in 2009 limiting our production, we decided to reorient our strategy towards the aerospace and automotive industries. Today, we have become a recognized specialist in technical weight reduction solutions, critical components and structural fastening systems. With over 60 years of experience with titanium, aluminium, special alloys and composite, our full service capabilities range from engineering, R&D to system integration and final turnkey packaging using the most technological equipment and processes available. Currently, aerospace represent 40% of our business (total 2015 turnover > €11.6 million). Regarding automotive, thanks to the close relationship between the industries of motorsport and automotive, we have been able to develop a robust customer base for high end products and limited series. Nonetheless, this segment occupies only 26% of our total business. With the ProFiT project and its revolutionary manufacturing process for titanium bolts, POGGIPOLINI will move from a semi-manual production (200,000 units / €13.5 production cost) towards a mass production process (potential up to 30 million units / < €5 production cost): the subsequent price reduction (> 60%) of the titanium bolts will allow us to expand our automotive market to general cars and by doing so increase our turnover by +€27 million by 2021.

Keywords: titanium,bolt,fastener,hot forging,alloy,automotive,aerospace
Escaping from the Franck-Condon region : a theoretical approach to describe molecular STructural ReorganIzation for reversible EnerGy and information storage at the Excited State (STRIGES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-11-01
End date: 2021-04-30
Duration (months): 66.0
Total project cost (EUR): 1202500.0
EU funding (EUR): 1202500.0
Participants: 1
Project status: CLOSED

STRIGES is a theoretical project aimed at developing new computational approaches and descriptors essentially rooted on Density Functional Theory enabling to design new single molecule architectures able to undergo to significant light induced electronic and structural reorganization. In this respect the present project concerns beside fundamental goals, such as the development of new theoretical approaches for the description of photochemical and photophysical processes in molecular systems, the description and prediction of photoinduced phenomena which is indeed of fundamental importance also in many research fields of technological relevance, ranging from artificial photosynthesis to molecular electronics. To this end, we will develop, implement and apply suitable theoretical tools enabling the accurate description of potential energy surfaces of the lowest lying excited states not exclusively within the Franck-Condon region. From the application point of view, the end point of this project is the in-silico design and optimization of two new classes of photomolecular devices.
Magnetic alignment for high precision 3D assembly (MAGALIGN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-01-01
End date: 2022-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

In microelectronics, 3D integration and assembly definitely appears as a very efficient option to achieve highly integrated chips. It offers major benefits such as combining heterogeneous technologies, combining high-performance and low-power chips, increasing data transfer bandwidth in memory above logic circuits, etc. 3D assembly is realized by bonding two wafers or chips face to face on a wafer. In this bonding process, the number of interchips interconnects is limited by the accuracy of the alignment process. Presently, alignment methods rely on optical alignment techniques which offer ±0.2m resolution for wafer-to-wafer bonding or only ±1m resolution for die-to-wafer bonding. This is relatively poor and limit the density of interconnects and therefore the bandwidth of interchip communication. In this ERC PoC project, we intend to establish the viability of a novel magnetic alignment approach based on nanomagnetism and spin electronics which could yield unprecedented accuracy in alignment during wafer bonding. The goals of MAGALIGN are i) to make a proof of concept of this novel alignment method, ii) optimize it and develop the design tools to exploit it, iii) Develop industrialization strategy.

Keywords: 3d integration,3d assembly,wafer to wafer bonding,chip to wafer bonding,magnetic field sensors,stt mram,co interconnects,magnetic alignment,optical alignment
Research into enhanced tracks, switches and structures (IN2TRACK)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Spain,Austria,Austria,Austria,Austria,Spain,Spain,Austria,Sweden,Sweden,Switzerland,Türkiye,Slovenia,Finland,Sweden,France,France,France,France,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal
Call: Research into enhanced track and switch and crossing system (H2020-S2RJU-CFM-2016-01-1, 2016)
Start date: 2016-09-01
End date: 2019-04-30
Duration (months): 32.0
Total project cost (EUR): 2799993.0
EU funding (EUR): 2799993.0
Participants: 33
Project status: CLOSED

Research into Enhanced Track, Switches and Structure The railway of the future needs to meet the predicted growth in societal demand in terms of capacity and service, address the environmental challenges of the 21st century, and enable the political objectives of the European Union. IN2TRACK is to set the foundations for a resilient, consistent, cost-efficient, high capacity European network by delivering important building blocks that unlock the innovation potential that have been identified as part of the Shift2Rail Innovation Programme 3. Overall objectives of IN2TRACK are divided into three parts; Enhancing and optimising the switch & crossings and track systems in order to ensure the optimal line usage and capacity; Investigating novel ways of extending the life of bridges and tunnel assets through new approaches to maintaining, repairing and upgrading these structures; Development and adoption of a holistic, whole system-approach. A whole-system approach ,which is defined as the system boundaries extending from dynamic wheel-rail interaction (loading input) through to degradation of the S&C system, sub-systems, individual components, and underlying track foundation, will also be at the heart of IN2TRACK on how to reach the objectives. This IN2TRACK proposal addresses each of the areas identified in the H2020-S2RJU-2016-01 call. IN2TRACK is fully aligned with Shift2Rail IP3 in its objectives, approach, and ambition; addressing early enhancements and innovation opportunities.

Keywords: tracks,switches and crossings,bridges and tunnels
Spatiotemporal dynamics of subcellular energy metabolism in astrocytes (AstroSignals)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The functional significance of subcellular compartmentalization in signal transduction has emerged in recent years, a development that is gaining momentum due to significant advances in optical microscopy and genetically encoded biosensors. However, much less attention has been given to the spatial architecture of the metabolic networks that provide energetic support for intracellular processes. This project will investigate spatiotemporal organization of energy metabolism in astrocytes, focusing on two hypotheses: • I propose that within astrocytes, signalling microdomains are energetically supported by local delivery of ATP. I will employ confocal and total internal reflection fluorescence (TIRF) microscopy, using biosensors for ATP, glucose and Ca2+ that can be targeted to subcellular locations. My initial focus is on cultured human astrocytes and the provision of ATP for Ca2+ signalling. Do the five cellular sources of astrocytic ATP support different ATP pools? Which pools are needed for the many ATP-requiring steps that link cell-surface receptors to Ca2+ signals? • I suggest that the ER lumen may provide a glucose reservoir that allows rapid intracellular transfer of glucose to meet local energy needs. The ER of astrocytes contains luminal glucose-6-phosphatase-β (G-6-Pase-β) and a glucose-6-phosphate transporter, which together can generate an ER luminal pool of glucose. The source of glucose-6-phosphate transported into the ER and the function of luminal glucose are unknown. Using cytosolic and ER-targeted glucose sensors, immunocytochemistry and siRNA knockdown of glucose G-6-Pase-β, I will determine the source of the glucose pool and whether it contributes to metabolic support of Ca2+ signals. Combining state-of-the-art techniques and expertise in the fields of cell signalling and metabolism, this project will enhance our understanding of metabolic regulation of signal transduction, opening new possibilities for targeted treatments of brain diseases.

Keywords: brain metabolism,subcellular compartments,atp microdomains,ca2 signalling,optical imaging
Server liquid cooling for Data Centres... done right! (serverChill)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Denmark
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 1558750.0
EU funding (EUR): 1091125.0
Participants: 1
Project status: CLOSED

With the accelerating increase of cloud-based services, the advent of the Internet of Things (IoT) and big data the IT sector is running into a fundamental bottleneck. Indeed, the demand for upscaling the computational power requires even denser server farms, whose thermal management of dissipated heat with conventional air-based cooling is both becoming technically unfeasible, environmentally questionable and economically unbearable. Thus, power/cooling is currently the #1 Data Centre (DC) design criteria. Asetek’s Direct-To-Chip liquid cooling solutions are based on the fact that water absorbs and conducts heat much more efficiently than air. This directly translates in computational performance gains, since the components can run at speed without overheating or undesired throttling thanks to efficient heat dissipation. Moreover, Asetek’s data centre-oriented liquid cooling solution – RackCDU D2C™, a disruptive server chassis with an integrated liquid piping that transfers heat from CPUs/GPUs and memory modules to flowing liquid through radiator interfaces – can even enable the dissipated heat to be recovered for building heating, thus reducing the cooling energy bill of data centres up to 70%. In addition, these significant savings are delivered while requiring only a 6% CAPEX increase for new DCs and having a <1 year investment payback time – thus providing a much stronger value proposition than direct competitors. The key market barrier to generate strong pull for RackCDU in the $5bn market of Data Centre cooling technologies is the very conservative and risk-averse mind-set of data centre managers. Thus, the core activities of the project primarily focus on large scale showcasing of RackCDU, which will enable Asetek to thoroughly anchor its communication around a fact-based strategy . This will propel our SME growth over the next decade, posing a potential business revenue stream allowing to graduate from its SME status within the first 5-years post-project.

Keywords: data centre thermal management,liquid cooling,computer room air conditioning,server cooling,server racks
An open, global, business directory with social networking tools for advanced leads discovery and online visibility in B2B digital marketing (twiner)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Digital marketing counts for half of the marketing budget of the average company, with email marketing and social media marketing coming on top of the preferred channels of communication, with an average of $400 spent monthly. However, when it comes to B2B activities, current tools do not fully satisfy the marketers’ needs. Getting email leads is based on somehow obsolete list broker services that offer paid access to -often local- business directories. Current social networks come equally short, as they are oriented to individuals, and companies have a static, merely expositional role with few or no real interactivity among them. Twiner is the outcome of our 15-year experience in email digital marketing and a natural continuation of Bancomail, our current list broker, which places us in a competitive position to transfer knowledge from the old way of conceiving B2B marketing (static business records) to a renewed approach (open directory + social network). Targeted to any SME, large corporation or NGO, looking to expand their B2B activities and gain visibility, it consists of an open, global business directory with a powerful search engine and social networking features. We use our 15M database to initially populate Twiner and the latest technology in data management and retrieval for fast DB access and best search matches. Compared to current alternatives, it offers free access to millions of business records, tools for connecting and interacting in a trusted environment, and various add-ons for centralizing all B2B activities like product showcasing, promotions, events etc. Thanks to this unique mixture, Twiner can increase by 90% the interaction within the company’s own network, and by 65% new relationships with companies of the sector. As it offers search trackers an openly accessible directory, it can increase by 30% web visibility. Following a “freemium” model, we will generate an accumulated profit of €69 million and ROI of 34,70 by the 5th year of launch.

Keywords: social network,email marketing