Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Large-scale pilots for collaborative OpenCourseWare authoring, multiplatform delivery and Learning Analytics (SlideWiki)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Italy,Germany,Germany,Spain,Spain,Spain,Germany,Germany,Germany,Greece,Serbia,Greece,Greece,Netherlands,United Kingdom,United Kingdom,Brazil
Call: Technologies for better human learning and teaching (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 7051240.0
EU funding (EUR): 6879040.0
Participants: 18
Project status: CLOSED

A major obstacle to increase the efficiency, effectiveness and quality of education in Europe is the lack of widely available, accessible, multilingual, timely, engaging and high-quality educational material (i.e. OpenCourseWare). The creation of comprehensive OpenCourseWare (OCW) is tedious, time-consuming and expensive, with the effect, that often courseware employed by teachers, instructors and professors is incomplete, outdated, inaccessible to those with disabilities and dull. With the open-source SlideWiki platform (available at SlideWiki.org) the effort of the creation, translation and evolution of highly-structured remixable OCW can be widely shared (i.e. crowdsourced). Similarly to Wikipedia for encyclopaedic content, SlideWiki allows (1) to collaboratively create comprehensive OCW (curricula, slide presentations, self-assessment tests, illustrations etc.) online in a crowdsourcing manner, (2) to semi-automatically translate this content into more than 50 different languages and to improve the translations in a collaborative manner and (3) to support engagement and social networking of educators and learners around that content. SlideWiki is already used by hundreds of educators, thousands of learners. Several hundred comprehensive course materials are available in SlideWiki in dozens of languages. In this large-scale trial project, we will further mature the SlideWiki technology platform, integrate it with a state-of-the-art MOOC delivery platform and perform four large-scale trials in (1) secondary education, (2) vocational and professional training, (3) higher education and (4) community-driven open-education. Each of these large-scale trials will be performed with hundreds of educators and thousands of learners in countries all over Europe. A particular focus of the technology development and testing in the trials will be the suitability for academics, teachers and learners with disabilities.

Keywords: opencourseware,linked data,collaborative authoring,crowdsourcing,multilinguality,vocational training,higher education,inclusion and accessibility
Global dynamics of topoisomerase-induced DNA breaks (TOPOmics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-11-01
End date: 2021-12-31
Duration (months): 74.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 259090.94
Participants: 2
Project status: CLOSED

DNA topoisomerases are conserved nuclear enzymes that regulate DNA topology by transiently cleaving and resealing the DNA molecule, fulfilling a fundamental role in virtually every aspect of chromosome metabolism. Nevertheless, erroneous or abortive topoisomerase activity can result in persistent DNA strand breaks with the enzyme covalently attached to 3’ or 5’ DNA ends by a phosphotyrosyl bond, an anomalous structure that can compromise cell survival and/or genome integrity with the consequent implications in tumourigenesis. This peculiarity of topoisomerase catalysis also underlies the anticancer efficacy of topoisomerase poisons, which inhibit the re-ligation step of the reaction inducing the formation of DNA breaks that preferentially target highly proliferating and/or repair defective tumour cells. In addition to this link with cancer therapy, defects in the repair of topoisomerase-induced DNA damage have been linked to neurological disease. Understanding the cellular response to topoisomerase-induced breaks is therefore key for important aspects of human health, with possible implications in the development of novel diagnostic, prognostic and therapeutic tools. This project aims at acquiring a comprehensive picture of the dynamics of topoisomerase-induced DNA breaks: from their occurrence and repair to the consequences for genome expression and integrity. We rely on the development of completely novel assays to detect and isolate the different intermediates of topoisomerase-induced break repair, and which overcome major traditional limitations in the field. These tools are subsequently used to integrate the time-dependent and genome-wide distribution of the different steps and final outcomes of the process of topoisomerase-induced DNA break repair. Furthermore, we outline original proteomic and genetic screenings to identify novel factors and pathways specifically involved the cellular response to this important type of DNA lesion.

Keywords: dna damage and repair,dna breaks,dna topoisomerases,genome instability
The role of RNA in centromere biology and genome integrity (cenRNA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-07-01
End date: 2022-06-30
Duration (months): 72.0
Total project cost (EUR): 1896250.0
EU funding (EUR): 0.0
Participants: 2
Project status: CLOSED

One of the most astonishing processes in the life of a cell is the division into two daughter cells. Such a highly organized process would presumably be regulated tightly by the underlying centromeric DNA sequence; however, the sites of chromosome attachment to the microtubule spindle are regulated by epigenetic mechanisms. The best-characterized epigenetic mark for centromeres is the histone H3-variant CENP-A, which replaces H3 in some of the nucleosomes within centromeric chromatin. Centromeres are embedded in pericentromeric heterochromatin and it has become apparent in recent years that heterochromatin is transcribed into non-coding RNAs. We have recently shown that a long non-coding RNA from pericentromeric heterochromatin of the X chromosome (SATIII) in Drosophila melanogaster localizes in trans to centromeres of all other chromosomes and is an essential component for correct loading and maintenance of CENP-A and, therefore, genome stability. Additional RNAs in Drosophila and RNAs from other species have been linked to centromeric chromatin, but their function is not understood. We propose that a complex, RNA-based epigenetic mechanism regulates centromere establishment and function. This proposal is designed to the precise function of SATIII RNA by identifying the associated protein complexes as well as structural and post-transcriptional features of SATIII. We will evaluate the mechanisms by which SATIII functions as a heritable mark of centromeres through generations, during the developing germ line, and species separation. In parallel, we will systematically identify and characterize centromere-associated RNAs (cenRNAs) in Drosophila and human cells. We will elucidate their function in centromere biology and chromosome segregation, essentially as we have done and propose to do for SATIII. These experiments are designed to provide a detailed understanding of the essential, RNA-based epigenetic regulation of centromeres.

Keywords: centromeres,non coding rna,heterochromatin
A direct, multi-faceted approach to investigate plant hormones spatial regulation: the case of gibberellins (GAtransport)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Israel
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-02-01
End date: 2022-01-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Plants evolved a unique molecular mechanism that spatially regulate auxin, forming finely tuned gradients and local maxima of auxin that inform and direct developmental patterning and adaptive growth processes. Recent findings call into question the uniqueness of polar auxin transport in the sense that more plant hormones seem to be actively transported. Although still lacking many mechanistic details, as well as comprehensive functional connotations, these findings warrant a more thorough investigation into the prospect of a broader scope for plants spatial regulation capacity in the context of additional hormones. Critically, we lack an effective set of tools to directly investigate and dissect the particulars of plant hormones mobility at the molecular level. My long-term goal is to provide a molecular and mechanistic understanding of plant hormones dynamics that will augment our evolving model of how they are regulated and how they convey information. Here, I hypothesize that GA mobility in plants is controlled and directed by an active transport mechanism to form distinct distribution patterns that affect signaling. I will test my hypothesis with a multi-faceted and multi-disciplinary approach, combining: fluorescent labeling of key gibberellins to map their accumulation sites in whole plants and at the sub-cellular level; chemical-biology strategies that facilitate manipulation of GA “origin point” in planta to map and quantify GA flow pathways; probe-based genetic screens and un-biased photo-affinity labeling to identify proteins affecting GA mobility; and genetic and molecular biology techniques to characterize identified proteins’ functions. I expect to offer an exceptional, detailed view into the inner workings of gibberellins dynamics in planta and into the mechanisms driving it. I further anticipate that the strategies developed here to specifically address gibberellins could be straightforwardly re-tailored to investigate additional plant hormones.

Keywords: plant hormone,phytohormone,gibberellin,transport,transporter,fluorescence,fluorescent probe,imaging,photochemistry,caging,proteins isolation
Photonics Solutions at Pilot Scale for Accelerated Medical Device Development (MedPhab)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Ireland,Austria,Ireland,Ireland,Austria,Austria,Finland,Switzerland,Belgium,Belgium,Finland,France,France,Czechia,Netherlands,Netherlands
Call: Photonics Manufacturing Pilot Lines for Photonic Components and Devices (H2020-ICT-2019-2, 2019)
Start date: 2020-01-01
End date: 2024-09-30
Duration (months): 57.0
Total project cost (EUR): 17381960.99
EU funding (EUR): 14995444.63
Participants: 22
Project status: SIGNED

Photonics technologies have become a key enabler in the realization of modern medical devices with applications ranging from diagnostics to surgical tools and therapeutics. Characteristic nature of both photonics and application fields is high diversity. Consequently, the more widespread use of photonics technologies in scattered ecosystems presents major challenges for both end-user companies and manufacturers. In conjunction with highly regulated validation and production, the timespan from the concept phase to product launch takes years. Addressing these challenges, MedPhab will serve as Europe’s first Pilot Line dedicated to manufacturing, testing, validation and up-scaling of new photonics technologies for medical diagnostics enabling accelerated product launch with reduced R&D costs. MedPhab will bring the high-quality infrastructure and extensive know-how within easy reach of the SME’s and other European Industry. Globally unique feature of MedPhab is its operation in medical domain setting requirements to meet regulations. The competitive differentiation is the seamless operation between ISO13485 certified companies and RTOs when single-entry point can serve SMEs operating at different TRLs. Professional customer interface will be operated by staff with extensive experience in the field medical devices. The technology readiness and MedPhab operation process will be validated by: 1) Use Case Validation program, upscaling and demonstrating performance of 5 innovative medical diagnostics products; 2) Demo Case Open Calls program enabling early adoption of the technologies by external user, demonstrating the pilot line services and validating the open access business model.

Keywords: medical diagnostics
Mechanosensing and Mitral Valve Prolapse: from the Molecular Mechanisms to the Progression of the Disease (MechanoMVP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-10-30
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Mitral valve prolapse (MVP) is the most frequent form of degenerative mitral valve (MV) disease and is a major cause of cardiovascular morbidity and mortality. No medical therapy is currently available. Familial and population genetic studies have identified genes causally related to non-syndromic MVP, such as FLNA, encoding for Filamin A protein. These findings have paved the road to study mechanisms and signaling pathways involved in the development and progression of MVP that will then be useful to identify potential therapeutic targets. This relies on two complementary approaches: a comprehensive phenotyping of the FLNA-MVP patients and the implementation of experimental models. In the MechanoMVP project, I propose to study stress-related mechanisms and regulation of signaling pathways involved in the development and progression of MVP based on the comprehensive analysis of the unique knock-in rat model for FLNA-P637Q mutation, as well as the related-cellular models, recently developed at the host institution. The specific actions I will conduct through this project are the comprehensive phenotyping of the unique rat model using multimodality imaging and biochemical approaches coupled with the cellular and molecular analyses done on mutant and WT valvular cell models. Based on this integrative approach mixing genetics, pathophysiological and mechanistic experimentations, and a multimodality/gold standard imaging phenotyping, MechanoMVP will provide landmark data in the field of MVP. In the context of a frequent CV pathology increasing with age and the rapid aging of the population, MVP and its ensuing adverse CV events will exponentially grow in the coming next years. With the only use of surgery to “treat” MVP patients, this disease will considerably increase the health care and socio-economic burden. MechanoMVP will open new avenues for the development of therapeutic approaches.

Keywords: animal model,cellular and molecular mechanims,genetics,mitral valve prolapse
Development of a Method for the Exploration the Joint Geology-Geophysics Model-Space (GeoMos)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-23
End date: 2023-08-22
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

Subsurface modelling using geoscientific data is essential to understand the Earth and to sustainably manage natural resources. Geology and geophysics are two critical aspects of such modelling. Geological and geophysical models have different resolutions and are sensitive to different features. Considering only geological or geophysical aspects often leads to contradictions as creating an Earth model is a highly non-unique problem. In addition, the sensitivity of the data is limited and many objects cannot be differentiated by a single discipline. The only way to address this is solving the longstanding challenge of integrating of geological data and knowledge (orientation data, contacts and ontologies) and geophysical methods (physical fields). Recent techniques usually focus on features the data is sensitive to and merely use one discipline to falsify hypotheses from the other. Such approach prevents considering the full range of potential outcomes, and fails to exploit the sensitivity of both approaches. This project proposes a different philosophy to solve the challenge of connecting geological and geophysical modelling. It first involves the development of a novel method integrating the two model types in a single framework giving them equal importance. Geological and geophysical data will be modelled simultaneously through an implicit functional mapping one domain into the other by linking their respective models. This will allow the simultaneous recovery of compatible geological and geophysical models. Secondly, this project will use a new hybrid deterministic-stochastic optimisation technique to explore the range of subsurface scenarios to estimate the diversity of features that cannot be differentiated based on the available data. Thirdly, after proof-of-concept, the method will be applied to two cases: imaging of a mantle uplift in the Pyrenees Mountains (France/Spain), and study of potential new subsurface scenarios around the Kevitsa mine (Finland).

Keywords: multidisciplinary geoscientific integration
Designing high-reliability interconnection materials for accelerated modern electrification (SuperSolders)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-17
End date: 2024-01-16
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: TERMINATED

The accelerated electrification in different sectors raises higher requirements on the reliability of electronics, which stimulates the demand for novel electronic interconnection materials. This proposed training-through-research aims to design new electronic interconnection materials to tackle three emerging bottlenecks in electronics manufacturing, which are i) low process-temperature solders to reduce energy consumption and facilitate 3D integration in consumer electronics, ii) high-reliability solders for harsh environments in the automotive and aerospace sectors, and iii) novel die-attach materials to enable the use of wide-bandgap power semiconductors. Advanced experiments and simulation techniques will be used to design novel solder alloys, study solidification microstructures, and evaluate the reliability and understand the deformation/failure mechanisms of solder joints. Comprehensive understandings on composition-processing-microstructure-property relationships will be built-up to drive the development of the three novel electronic interconnection materials in this project: i) novel multi-compositional low-temperature solders with refined microstructure and excellent ductility and strength superior to conventional Sn-Bi solders, ii) advanced high-reliability solders strengthened by mechanisms from microstructures of different scales including not only solid solutions and secondary phases but also grain structures and orientations that have not been incorporated by current solders, and iii) novel transient liquid phase bonding (TLPB) materials that can significantly reduce the processing time and produce refined high entropy intermetallic bonds with mechanical properties overmatching current TLPBs. This inter-/multi-disciplinary project promises a tremendous positive impact on the European consumer electronics, power electronics, and automotive and aerospace sectors, contributing to the European excellence, competitiveness, and quality of manufacturing.

Keywords: pb free solders,solidification,intermetallic,microstructure,reliability
Bringing to market an open source CFD framework as a fully automated simulation service with high performance computing cloud-based access (Adaptive Simulations)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Sweden
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-02-28
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Computational Fluid Dynamics (CFD) uses numerical analysis and algorithms to predict flow with a computer. CFD analyses not only fluid flow behaviour, but also mass, phase change, chemical reactions, mechanical movement, the transfer of heat, and stress/deformation of related solid structures. Rapid progress over the past two decades in computational power, comprehensive physical models, and advances in numerical methods has made it possible for engineers to use CFD simulations routinely in a wide range of industrial, environmental and biomedical applications across various industries including aerospace, automotive, chemical engineering, healthcare, and more. It is increasingly used to complement or replace wind tunnel simulations in the automobile and aerospace sectors. The many applications for CFD all create great value in terms of increased product performance and time to market. However, CFD simulation requires specialized engineers performing manual preparation and post-production tasks, expensive CFD software licenses and intensive computing resources that small and medium size enterprises cannot afford. Likewise, many sectors that could benefit from CFD simulation to simulate heat and cooling airflow for energy optimization (like architecture and construction) find CFD costs prohibitive. Many large enterprises, like our client Thule, have to turn to expensive consulting services rather than investing in in-house CFD solutions. Adaptive Simulations has developed a breakthrough simulation-as-a-service solution which automates CFD simulation and drives costs down by 70%. Our innovation will democratise CFD for the Industry 4.0 revolution. This phase 1 project will validate the technical and commercial feasibility of fully automated flow simulations as a service, continuing our customer development to date. We will recruit organisations willing to trial the solution in phase 2 ahead of large-scale deployment across a range of sectors and users.

Keywords: simulation,engineering,computational fluid dynamics