Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hodgkin Lymphoma: Insights from genomic studies of mutations in coding and non-coding regions (HodgkINsights)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-07-08
End date: 2025-07-07
Duration (months): 36.0
Total project cost (EUR): 275209.92
EU funding (EUR): 275209.92
Participants: 1
Project status: SIGNED

Classical Hodgkin Lymphoma (cHL) is one of the most common cancers in young adults. While chemo-radiotherapy is effective, many patients continue to die of cHL or to suffer long-term treatment toxicities, such that more effective and less toxic drugs are needed. Studying the mechanisms underlying the puzzling biology of cHL (the only B cell-derived lymphoma loosing its B-cell identity) should illuminate its pathogenesis and possibly aid in developing better therapeutic strategies. In this project, I will study the function of mutations in the DNA binding domain of the STAT6 transcription factor, which the host laboratory identified as one of the most frequent genetic lesions in cHL. I will perform genome-wide ChIP- and RNA-seq studies to uncover aberrant gene expression regulation and occupancy by mutant versus wild-type STAT6 in cHL versus non-Hodgkin lymphoma (NHL) cell lines, and investigate their functional consequences at the cellular level. I will then express mutant STAT6 in germinal center (GC) B cells, the cHL cell of origin, to evaluate their role in early lymphomagenesis. Because genes mutated in cHL greatly overlap with those altered in NHLs, from which cHL is strikingly different, I will also explore whether unidentified mutations in non-coding regulatory regions may underlie the peculiar cHL pathogenesis. Recurrent somatic non-coding mutations will be identified through whole-genome sequencing of primary cases and will be annotated to the non-coding elements specifically active in cHL cell lines, which I will identify through RNA- and ChIP-seq for key histone marks. Finally, I will use appropriate techniques (e.g., genome topology and CRISPR editing) to assess how such mutations may alter regulatory networks important for cHL biology and identity. The project will also expand my expertise in genomic regulation in lymphomas, boost my research productivity after a career break, and support my transition to an independent investigator.

Keywords: hodgkin lymphoma,stat6 mutations,non coding functional mutations
Desalination technology for the water challenge of the 21st century (SonixED)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-06-01
End date: 2023-11-30
Duration (months): 30.0
Total project cost (EUR): 3277250.0
EU funding (EUR): 2294075.0
Participants: 1
Project status: SIGNED

Hydrovolta has created SonixED the first equipment combining traditional Reversal Electrodialysis (EDR) technology and ultrasound, which has the capacity to replace conventional desalination with a 60% higher efficiency, while reducing the environmental impact in CO2, Chemical use, and plastic waste. There is a growing need for access to freshwater, as water demand is predicted to increase significantly over the coming decades, accelerated by Earth’s global warming. Because only 2.5% of the water resources on our planet consist of freshwater, desalination technologies will become a vital part of the water treatment landscape. There is a market need to increase the total existing desalination capacity in the world, by a third in the next 10 years. Current desalination technologies exist for centuries and have strong drawbacks which do not make them viable for meeting the worlds water demand of the future. SonixED has a drastically higher efficiency thanks to the integration of ultrasound technologies, preventing fouling and optimizing the efficiency of the membrane. SonixED is a €20bn market opportunity. We want to provide two types of containers for Seawater and Brackish water applications. We will assemble simple modules into skids that will be the central part of the equipment sold and can be scaled easily, the system will also include remote monitoring. After a positive pilot phase, we will organize 3 field trials during this EIC pilot, supported by prospects in the two use cases. In parallel, we will prepare our industrialization by adapting the design of our modules, skids, and containers to be produced and assembled through industrial processes. We will also prepare our manufacturing and logistic capabilities and develop marketing and commercial strength. The SonixED will be commercialized as soon as possible over a global network of distributors, utilizing the existing network of the founding members.

Keywords: water recycling,water desalination,water reuse,reverse osmosis,electrodialysis reversal
Establishing services enhancing the innovation management capacity of SMEs by the Enterprise Europe Network in North Rhine-Westphalia, Germany, in 2019 (Innovation.NRW_1)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Germany,Germany
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 280901.25
EU funding (EUR): 280901.25
Participants: 3
Project status: CLOSED

Innovations and thus also the management of innovations are of great significance for the competitiveness of the European Union, its Member States and their regions. Innovative individuals or enterprises do something which cannot be expected from the state of the art. They put innovations into practice – generally in the face of considerable resistance – and take financial, technical as well as social risks. Only in this way, however, can new technologies, processes, products or services assert themselves and future markets evolve. Employment, prosperity and the general quality of life and of the environment are directly dependent on the innovation capacity of regions and enterprises. Due to this interrelationship, the European Commission has promoted the Enterprise Europe Network since 2008 in order to provide local support above all to SMEs in the areas of internationalization, technology transfer and generally in the realization of innovations. One of the Network’s tasks is to raise the effectiveness and efficiency of innovation management in SMEs in order to accelerate the implementation of economically impactful innovations. Supporting SMEs in the area of innovation is a core task and the mission of ZENIT, coordinator of NRW.Europa, the Enterprise Europe Network node in North Rhine-Westphalia. Whilst innovations naturally cannot be forecasted, they can, however, evolve under the right conditions and be successfully managed. Our understanding of innovation and innovation management is oriented at business opportunities. As a consequence, ZENIT is pursuing the following objectives in the Innovation.NRW project: • To maintain and expand the innovation capacity and competitiveness of the participating SMEs • To help the key SME beneficiaries so that their full innovation potential can be exploited

Keywords: eimc,innovation,management,zenit,client journey,spoke,impact,network,nrw europa
Automating what is not automatable Automated defect diagnosis and Machining system for manufactured parts. (SCR4.0)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

ASAI is a Spanish SME bringing quality industrial automation to our clients in the automotive and other diverse industries. We have broad technical knowledge in scanning, robotics, software and automation and strong, management, industry knowledge, and supplier links for completion of the SCAN-CAM-ROBOT 4.0 (SCR4.0) project. Our aim with the SCR4.0 is complete automation of the final quality control and machining process. The current process requires measurement of the manufactured part, comparison with required geometry and machining of the part. 3 separate activities linked by human operators using software and equipment. These solutions are slow, costly, and inefficient. For example, in the aluminium injection casting industry machining costs are 20 to 50% of average completed part and cause time delays of up to 75% for a part and material wastage of up to 15%. The SCR4.0 will automate the entire process, in one smart integrated manufacturing cell that is compatible with Industry 4.0 for full factory and supply chain automation. Leading to Increased productivity (up to 33%) and lower costs (up to 50%) in just the first 3 years including payoff. Selective machining by the SCR4.0 will be possible by inline 3D scanning of all parts achieves extra energy and material savings (up to 20%). Industry 4.0 (factories of the future) is growing, expected to reach €139 Billion by 2024. Our target material, Aluminium, is increasing in the automotive industry for light-weighting for emissions reduction, expected to reach 20% of material by 2026; with an increase in required complex machining for mechanical parts. Metal injection moulding (our customers primary activity) is to grow from €2.3 Billion in 2017 to € 3.35 Billion by 2022. With an additional €2.3M investment, we can bring the SCR4.0 to this growing market through our global customer network and new links with aluminium parts manufacturers. Given the demonstrated savings they will be keen to implement the SCR4.0.

Keywords: 3d scanning,artificial vision,automated optical metrology,computer aided manufacturing,cognitive intelligence,aluminium injection moulding,composite materials,machine learning
Robotic Production of EPS Formwork for cost-effective Concrete Stairs (SMARTSTAIR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-03-01
End date: 2023-06-30
Duration (months): 40.0
Total project cost (EUR): 1354245.0
EU funding (EUR): 947971.5
Participants: 1
Project status: SIGNED

Founded in 2012, Odico A/S is an international pioneer in the emerging field of ro¬botics for the construction industry. In 2014, Odico became the first company in the world to produce form¬work (i.e. molds for concrete casting) with robotic hotwire cutting and Expanded Polystyrene (EPS) blocks for a commercial project – the iconic Fjordenhus in Vejle (Denmark) designed by the world-famous artist Olafur Eliasson. We have completed over 250 robot manufacturing projects in 6 countries, in¬cluding several high-profile construction projects, such as the Opus Dubai building. Today, producing formworks (i.e. molds) for a typical concrete staircase takes up to 4 person-days. Our SmartStair innovation will do this in under 30 minutes; 64x faster than existing technology. SmartStair is a containerized, full-feature robot production system developed by Odico and currently patent-pending. It replaces non- value-added manual work and enables concrete manufacturers to slash formwork manufacturing costs by up to 88%. The system comprises a) an industrial robot with b) a proprietary wire-cutting tool, c) groundbreaking robot control software developed by Odico, and, d) all assembled in a containerized Internet-of-Things (IoT) platform. With the easy-to-use SmartStair App for iPad, the concrete pre-manufacturer designs the formwork according to project specifications, in just a few minutes. SmartStair addresses our customers’ severe pain points: building formworks for staircases is expensive, time-intensive and generates +100M tons of timber waste annually in Europe alone. The market opportunity is massive. Our Total Addressable Market is €2.13Bn and will reach €2.48Bn by 2026 at a CAGR of 5%. We aim to rapidly penetrate this market by introducing a far superior technology. Through our hardware + software licensing business model, we expect a market share of 1.8% (of Serviceable Available Market), a turnover of €23.5M, EBITDA of €6.5M and headcount of 87 people by 2025.

Keywords: sustainable construction,digital construction,transportable robotic formwork production system
Dielectric MicroSpacer Technology (DMS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Italy
Call: FET Innovation Launchpad (H2020-FETOPEN-4-2016-2017, 2016)
Start date: 2017-04-01
End date: 2018-09-30
Duration (months): 18.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

Several technological applications need tools for keeping a stable micrometric distance between two surfaces. The requirements are more stringent if electrical insulation has to be guaranteed between the surfaces and even more if also thermal insulation has to be satisfied. The dielectric microspacers (DMSs) here described represent a microtechnology able to meet all these requirements. DMSs were developed in the ProME3ThE2US2 FET project to separate two electrodes of an innovative high-temperature solar cell prototype. Since that device is part of the wider set of thermionic energy converters (TECs), DMS technology can be successfully applied to them, thus solving a technical problem only mitigated by palliative solutions during the last 50 years. The potentials connected to DMS technological innovation are scalability, robustness, high resolution, fabrication on large areas, thermal resistance and stability, very high electric and thermal resistivity, uniformity of physical properties, versatility of arrangement, and very accurate control of the separation gap. As mentioned, the immediate application is in TECs, initially for nuclear and aerospace applications and subsequently for allowing their introduction in the enormously increasing sector of industrial waste heat recovery. Application is expected also in fabrication of electronic devices. However, since new devices require effective and performing tools, in the same way as new tools open new perspectives for hi-tech devices, novel applications can be imagined. With this aim, DMS project starts with a critical study on possible complementary applications as well as on technical limitations and improvements. This activity will be preparatory for protecting the intellectual property in the widest possible application domain. A second phase will focus on technology transfer by qualifying and quantifying the possible market(s) and actors, aimed at defining an effective exploitation plan and promotion strategy.

Keywords: hi tech,microtechnology,energy conversion,micromachining,patenting,technology transfer
The emergence of Modern Hebrew as a case-study of linguistic discontinuity (EMODHEBREW)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Israel
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2020-12-31
Duration (months): 39.0
Total project cost (EUR): 1037669.08
EU funding (EUR): 1037669.08
Participants: 1
Project status: CLOSED

The pioneering enterprise I propose is the study of a particular type of linguistic discontinuity – language revival – inspired by the revival of Hebrew at the end of the 19th century. The historical and sociocultural dimensions the revival have been studied before, but not its linguistic dimensions. My main aim is to construct a model of the linguistic factors which have shaped the revival of Hebrew. I expect this model to provide clues for the understanding of the process of language revival in general. For a language to be revived, a new grammar must be created by its native speakers. I hypothesize that the new grammar is formed by some of the general principles which also govern other better known cases of linguistic discontinuity (creoles, mixed languages, emergent sign languages etc.). The model I will develop will lay the foundation for a new subfield within the study of discontinuity – the study of language revival. I will start with careful work of documenting the development of the grammar of Modern Hebrew, in particular its syntax, something which has not been done systematically before. One product of the project will be a linguistic application for the documentation and annotation of the novel syntactic constructions of Modern Hebrew, their sources in previous stages of Hebrew and in the languages with which Modern Hebrew was in contact at the time of the revival, and the development of these constructions since the beginning of the revival until the present time. The linguistic application will be made available on the web for other linguists to use and to contribute to. The institution of an expanding data-base of the syntactic innovations of Modern Hebrew which comprises both documentation/ annotation and theoretical modeling which could be applied to other languages makes this an extremely ambitious proposal with potentially wide-reaching ramifications for the revival and revitalization of the languages of ethno-linguistic minorities world wide.

Keywords: the issues are theoretical in the fields of historical syntax and contact linguistics,and do not require knowledge or expertise in hebrew there are no examples in hebrew within the proposal
polyValent mEsopoRous nanosystem for bone DIseases (VERDI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Finding simple solutions to complex problems has been a challenge for humankind for decades. VERDI aims at designing a multifunctional nanosystem to heal complex bone diseases. This is an engineering challenge that will be tackled through the use of building blocks designed on the basis of cutting-edge technology. These building blocks will be assembled into a versatile multifunctional nanosystem that can be adapted through slight variations for the treatment of three diseases of clinical relevance: bone infection, bone cancer and osteoporosis. The novelty of this proposal is the design of a nanosystem that may address several diseases using a unique, versatile and scalable strategy. Mesoporous silica nanoparticles are selected as the main component of the nanoplatform because of their biocompatibility, robustness, loading capacity and versatile surface modification. The nanosystem will be modified by rational selection of building blocks, with targeting and/or therapeutic abilities, to tackle either one or a combination of pathologies. These features will enable us to deliver a library of nanomedicines using a toolbox of building blocks, customizing a specific nanosystem depending on the disease to be treated. The risks associated to VERDI are numerous, such as the great complexity of producing completely asymmetrical nanoparticles (NPs), the risk that modifying a drug or therapeutic peptide will affect its therapeutic efficacy, and the difficulty of achieving effective in vivo bone targeted NPs. A contingency plan for each risk has been elaborated. The expertise and capacities of my research group guarantees successful results, which we expect to lead to a revolution in the therapy of bone cancer, bone infection and osteoporosis. Additionally, the application of a single technology for the treatment of three different but frequently associated diseases will favour industrial scale-up process, thereby promoting the transition of nanomedicine from bench to bedside.

Keywords: mesoporous silica nanosystems,nanoplatform,bone infection,bone cancer,osteoporosis
Enhancing water quality by developing novel materials for organic pollutant removal in tertiary water treatments (MAT4TREAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Italy,Argentina,South Africa,Greece,Denmark,Canada,Denmark
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 630000.0
EU funding (EUR): 630000.0
Participants: 10
Project status: CLOSED

The MAT4TREAT project consists in a consortium of 8 Universities, 5 of them European (UNITO, AAU, POLITO, UPV and UOI), and the other three from outside the EU (UNLP, McGill, SU), as well as two non academic institutions (ACEA and LQT). These groups are committed to work in the development of novel materials to be used in innovative integrated water tertiary treatments (to remove, for instance, Emerging Pollutants). This ambitious goal will be achieved by world leading research groups in the following fields: (i) graphene-based and other carbon-related materials, (ii) polymeric materials, (iii) oxidic ceramic materials, and (iv) hybrid inorganic-polymeric materials. The new materials will be used as adsorbents, as photocatalysts and as active layers for the fabrication of membranes, and thus tested for the pollutant removal from model aqueous solutions as well as from real water samples. Furthermore, approaches combining different materials and pollutant abatement technologies will be proposed and a demonstrative lab-bench apparatus for the integrated treatment of wastewaters will be built-up with the support of two European non academic institutions, which will directly participate to the project. Chemometric approach will be followed to optimize both materials production and experimental conditions for analytical purposes. Life Cycle Assessment of new materials and proposed technologies will be performed in order to evaluate their economic and environmental sustainability. For the implementation of the program secondments of ESRs and ERs are scheduled (95 secondments for 142 person-months) together with a diffusion plan to report on the obtained results, not only to the scientific community, but also to stakeholders and non-specialized audience.

Keywords: novel materials,material synthesis,material characterization,adsorption,photocatalysis,filtration,biocatalysis,hybrid materials,life cycle assessment,chemometrics,pollutants abatement