Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Multi-leg precision calculations and advanced phenomenology in the LHC era. (MULTI-LEG@LHC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 226548.4
EU funding (EUR): 226548.4
Participants: 1
Project status: CLOSED

The Large Hadron Collider (LHC) running actually at CERN, Geneva, is the most powerful man made high energy particle collider. It will enable us to observe or exclude the Standard Model Higgs boson, to clarify the nature of the electroweak symmetry breaking (EWSB) and to find possible signals of physics beyond the Standard Model (SM). Search for new physics signals at the CERN LHC frequently involves multi-particle final states, consisting of jets, leptons, photons and missing energy. Meaningful searches for these signatures require not only a very good knowledge of the expected signal, but also of all the SM backgrounds yielding identical final state signatures. Since leading-order calculations are affected by large uncertainties, next-to-leading (NLO) order corrections are necessary. For a long time, these corrections were available only for at most three final state particles. The current frontier of complexity are NLO calculations of 2 -> 4 reactions. The aim of this project is to carry out, on the one hand, several phenomenological studies of relevant processes for Higgs discovery and new physics searches at the LHC for 2 -> 4 processes at the one loop level. We will perform novel NLO QCD calculation of several multi-leg processes involving vector bosons and the top quark. On the other hand, we propose a novel technique to compute diboson production channels at approximated NNLO accuracy. The timeless and relevance of the project is given by the running of the LHC. We will release all the calculations as a Monte Carlo program to be used by the experimentalist to analyse data. The project will be performed at IFIC, a world leader centre for theoretical and experimental research in particle physics.

Keywords: physical sciences,quantum field theory,lhc phenomenology,multi-leg nlo qcd,vector bosons,photons,monte carlo tools for experimentalist,automatation
Evolution of plasmid-mediated resistance in Pseudomonas aeruginosa (PLASREVO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-10-01
End date: 2014-09-30
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

Antimicrobial resistance in bacteria is currently one of the most concerning threats for public health. Up to 400,000 patients suffer from infections resistant to multiple antibiotics in Europe annually, giving rise to more than 18,000 deaths every year. Hence, a better control of the rise and spread of antimicrobial resistance in pathogenic bacteria is crucial to improve the health of European citizens. Bacteria acquire resistance to antibiotics through two principal routes, (i) chromosomal mutations and (ii) plasmid acquisition. Plasmids are extrachromosomal DNA elements responsible for the spread of antimicrobial resistance determinants among bacteria, as they can disseminate by horizontal gene transfer (conjugation and/or transformation). Previous works have shown that aspects as the mechanistic basis of drug resistance and the antibiotic treatment regimes are crucial for understanding the evolution of population genetics of chromosomal-mediated resistance. Here, we would like to determine the key population genetic parameters that influence the rising and the spread of plasmid-mediated resistance. Specifically, we will determine for both (a) plasmid and (b) chromosomal-mediated resistance: (i) The rate of acquisition of resistance. (ii) The fitness costs and benefits of resistance. (iii) The potential for compensatory adaptation to ameliorate the cost of resistance. We will quantify these parameters using in vivo and in vitro experimental evolution experiments with the pathogenic bacterium Pseudomonas aeruginosa. This work will help us to understand and prevent the concerning phenomenon of antimicrobial resistance spread among pathogenic bacteria, and will provide information of biological and clinical relevance to make predictions about how innovative therapeutic approaches could impact plasmid-mediated resistance dynamics.

Keywords: health sciences. microbiology. antimicrobial resistance. horizontal gene transfer. plasmid biology. evolution. genomics and general genetics.
New chemical platforms for targeted radiopharmaceuticals based on generator-produced metal isotopes (RADIOPHARM METAL ISO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 209033.4
EU funding (EUR): 209033.4
Participants: 1
Project status: CLOSED

Targeted radiopharmaceuticals for diagnosis and therapy are important in the development of a personalised medicinal approach in oncology. The radiometal isotopes, Ga-68, Tc-99m and Re-188 are particularly useful as they are sourced from a generator and their decay properties are amenable to PET diagnosis, SPECT diagnosis and radiotherapy respectively. This project aims to develop new radiochemical platforms for these isotopes, expanding their utility in nuclear medicine. For Tc-99m and Re-188, multivalent bifunctional chelators will be synthesised, which will be conjugated to the bone cancer targeting group, bisphosphonate, or an analogue of the melanoma targeted peptide, alpha-melanocyte stimulating hormone (aMSH). The new radiolabeled tetravalent compounds will be assessed for targeting efficacy using in vitro and in vivo models. Furthermore, in vivo experiments will determine whether any enhanced tumour accumulation for aMSH-derived multivalent tracers radiotracers (relative to analogues of lower valency) is truly a multivalent effect or a result of prolonged bioavailability. In the case of Ga-68, a novel pretargeting, “reverse-multivalent” approach will be developed, with the aim of decreasing radiation present in non-target organs. This requires multiple copies of a chelating group to be attached to a targeting agent, in this case, an aMSH analogue. This unlabelled agent will bind to the target receptor in vivo prior to injection of a Ga-68 formulation. Complexation of the radiometal at the in vivo target site will be achieved through incorporation of a chelating group that demonstrates high affinity and rapid binding for Ga3+. These new radiochemical platforms for generator-produced isotopes will be developed with a view to clinical translation in the multidisciplinary environment at the Division of Imaging Sciences, King’s College London.

Keywords: nuclear medicine,technetium,gallium,rhenium,spect imaging,pet imaging,radiotherapy,molecular imaging,melanoma,amsh,bisphosphonate,multivalent,bone metastates,peptide conjugation
Prophylactic and therapeutic use of recombinant lymphocytic choriomeningitis virus against melanoma (LCMVACC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-04-01
End date: 2014-03-31
Duration (months): 24.0
Total project cost (EUR): 192622.2
EU funding (EUR): 192622.2
Participants: 1
Project status: CLOSED

Cancer is one of the most common reasons for death of people living in the developed countries. There were an estimated 3.2 million new cases of cancer and 1.7 million deaths in the year 2008 in Europe. Melanoma is a form of skin cancer caused by mutation of melanocytes in the skin. Common cancer therapy is not effective in treatment of metastatic melanoma. The survival rate of patients with this form of the disease is very low, indicating the need for development of new therapeutic options. The proposed research aims towards developing vaccination strategies that can be used for prevention or therapy of melanoma. Recent work in the field of cancer vaccination indicates high potential to improve and prolong the life of the patients. In the proposed research, the use of a new and very safe vaccine vector based on the modified lymphocytic choriomeningitis virus (rLCMV) for fight against cancer will be elucidated. The roll of immune cells to break the normal tolerance of the organism to tumour cells will be investigated and characterised. By conducting this research, not only cancer vaccination will be brought closer to application in patients, but additional insight into the mechanisms underlying immune tolerance against cancer will be gained. Cancer vaccination is a very timely scientific field and progress in this area will be noticed by the general public worldwide. The research will be conducted in the Dermatology Department at the University Hospital of Lausanne, Switzerland. The researcher is from Germany and has been working in the Department of Virology at the Bernhard-Nocht-Institute for Tropical Medicine in Hamburg. By performing the proposed research, the applicant will get additional interdisciplinary training on immunological methods and vaccination strategies. By adding these competencies, he will afterwards be able to establish his own work group focussing on viral pathogenesis and vaccination at a European research institute or university.

Keywords: anticancer therapy,dermatology,vaccines,recombinant virus,melanoma
Relativistic electron beams and radiation sources using high power laser produced plasmas (REBRADLAP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-09-01
End date: 2013-08-31
Duration (months): 12.0
Total project cost (EUR): 134548.2
EU funding (EUR): 134548.2
Participants: 1
Project status: CLOSED

This proposal describes a program of research to be carried out by Prof. Karl Krushelnick of the University of Michigan during a 12 month visit to ENSTA-LOA in Paris. He will join the world-leading laser plasma acceleration group of Dr. Victor Malka at LOA. This research involves the use of the highest power, shortest pulse laser systems available for producing relativistic plasma waves capable of accelerating electron beams to GeV range energies. This is a rapidly growing field of research and Prof. Krushelnick has significant experience in diagnostic development and experimental design for short pulse laser interaction experiments. During this visit he will be involved in development of new techniques for increasing the energy and charge of the electron beams produced in the experiments as well as studying the plasma physics of the beam generation. This will involve the use of new diagnostic systems (such as XUV spectroscopy, particle probing, and spectrally resolved imaging techniques) developed at Michigan. In addition such compact relativistic beams are potentially excellent sources of high energy radiation for many applications, and during his visit he will be involved in the development of new techniques for enhancing the properties of these sources, including improvements in the flux and reduction of the pulse duration. Measurements to understand the physics of the radiation process by detailed measurement of the spectrum produced will also be undertaken.

Keywords: physical sciences,applied optics,radiation physics,experimental physics
Mind the Gap: Mechanism and Impact of Ceramide Trafficking at the ER-Mitochondrial Interface (MECETERMITI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-06-01
End date: 2015-07-31
Duration (months): 24.0
Total project cost (EUR): 174475.2
EU funding (EUR): 174475.2
Participants: 1
Project status: CLOSED

A principal cause of failure in the treatment of cancer is that cancer cells develop resistance to chemo- and radiotherapy, leading to recurrence of the disease or even death. Sphingolipid molecules can modulate the ability of malignant cells to grow and resist anticancer regimens, with some molecules promoting tumorigenesis and others acting as tumor-suppressors. The tumor-suppressor activity of ceramides has prompted development of different formulations of synthetic ceramides in anticancer therapies, but the poor solubility of these compounds restricts their biocompatibility. Therefore, attention is increasingly focused on possibilities to manipulate cellular sphingolipid balances from within. The recent discovery of a ceramide sensor that protects cells against ceramide-induced cell death marks an important breakthrough. Disrupting sensor function causes accumulation of ceramides in the endoplasmic reticulum (ER) and their flow into mitochondria, triggering a mitochondrial pathway of apoptosis. While these results define the transfer of ER ceramides to mitochondria as a key determinant of cell fate, the molecular principles that govern ceramide trafficking at the ER-mitochondrial interface remain to be established. In this project, I aim to unravel the transport mechanism by which ER ceramides can reach mitochondria to initiate apoptosis. I will conduct a chemical screen employing photoactivatable and clickable ceramide analogues to identify ceramide-binding proteins operating at the ER-mitochondrial interface. As complementary approach, I will conduct a functional screen to search for proteins required for delivering ER ceramides to mitochondria. This screen is based on the principal that blocking expression of such proteins would prevent cells with a disrupted ceramide sensor from committing suicide. Finally, I will evaluate newly-identified components of the ceramide trafficking machinery as targets for modulating drug-induced apoptosis in tumors.

Keywords: cytology,sphingolipid signalling,lipid transfer protein,ceramide sensor,bifunctional lipid,membrane contact sites,mitochondrial apoptosis,cancer biology
Optimizing Research tools for Cetaceans in Archaeology (ORCA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-09-10
End date: 2014-09-09
Duration (months): 24.0
Total project cost (EUR): 209033.4
EU funding (EUR): 209033.4
Participants: 1
Project status: CLOSED

Whale hunting has been practiced by a variety of cultures worldwide for millennia, and played a key economic and sociological role. Today, whales are one of the most threatened groups of mammals, almost exclusively due to recent industrial hunting practices. Archaeological investigations into the history of whaling are vital for understanding the long-term exploitation of these important marine mammals, and also because they provide essential ecological baseline data on whale populations prior to industrial overhunting. Previous investigations both into the pre-history and contemporary impacts of whaling have been hampered by difficulties in accurately identifying fragmentary archaeological whale bones. Innovative new biomolecular approaches, however, can provide accurate information on the distribution, diversity and population sizes of whale populations through time. By pairing the ancient DNA and archaeological expertise of the applicant with the state-of-the-art facilities and specialists at BioArCh, York, this proposal seeks to a) develop and compare two rapid, low-cost, and highly-accessible cetacean identification techniques using proteins (ZooMS) and ancient DNA analysis; and b) apply these methods to explore whale exploitation patterns over the last 4000 years. Through the identification of over 1,000 geographically and chronologically documented archaeological whale remains, ORCA will: 1) investigate the taxonomic abundance and distribution of whale species through time and space; 2) explore how accurate species identification affects current hypotheses on the prehistory of whale hunting and exploitation in the NE Atlantic and NE Pacific, and; 3) document the distinct demographic histories of Atlantic and Pacific gray whale. ORCA will address both archaeological and conservation biology issues by revealing the long history of whale hunting, while providing invaluable baseline data immediately applicable to modern whale conservation and management.

Keywords: archaeology,biodiversity indicators,genomics,proteomics,molecular genetics,aquatic ecology,conservation biology,habitat and species restoration and rehabilitation
Authentication of meat products using ambient surface mass spectrometry (AUTHENTIMEAT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-06-11
End date: 2014-06-10
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

The research objective of the project is authentication of meat products using ambient surface mass spectrometry : desorption electrospray ionization (DESI) and plasma-assisted desorption/ionization (PADI) mass spectrometry. In recent years, authentication of meat products has been gaining in practical importance throughout the world due to economical reasons, religious and moral objections. Adulteration can be also hazardous due to occurrence of food allergies to meat proteins. Implementation of effective techniques such as DESI and PADI that could be applied without preliminary sample preparation will be a breakthrough in meat products authentication. This will result in a novel, fast, innovative method that will allow analysis of complex meat products (e.g. sausages, canned products). For this purpose a multidisciplinary team spanning researchers with different backgrounds was build: Prof. Barret (scientist in charge) has expertise in analytical bioscience, Prof. Alexander in characterising organic surfaces, Prof. Tucker in molecular biology and food authentication, the applicant has experience in food science and proteomics. The School of Pharmacy at the University of Nottingham has an international reputation for its research in surface analysis and expertise in state-of-the-art biochemical analytical technologies. The collaboration will result in integration of the applicant into a highly competitive international research group. The resulting training will enhance the applicant individual competence diversification and will deliver high quality career development in attaining a leading independent position in education with wide applicability across the EU. The project will contribute to improving food safety and to reduce cases of adulteration. The results will have a positive impact on the EU citizens as well as increase research and innovation potential in Europe through leadership in ambient mass spectrometry and its application to fraud detection.

Keywords: natural sciences,life sciences,food safety,meat products authenticity,skeletal muscles,proteins,ambient surface mass spectrometry,desi,padi
How do groundwater-surface water interactions control recharge from ephemeral streams? (EPHEMERAL GSI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2012-11-01
End date: 2015-10-31
Duration (months): 36.0
Total project cost (EUR): 294929.7
EU funding (EUR): 294929.7
Participants: 1
Project status: CLOSED

The aim of this Fellowship is to develop the first detailed process understanding for how groundwater-surface water interactions (GSI) control indirect recharge in ephemeral stream catchments. Such research is urgently needed to underpin sustainable water resources management in the context of global change. A multidisciplinary approach will be taken to integrate innovative and detailed field monitoring and analysis of a study catchment in New South Wales (NSW), Australia, with state-of-the-art numerical modelling techniques to derive process understandings transferable to other catchments. The sensitivity of groundwater recharge to future scenarios of changing landuse, climate and groundwater abstraction will be assessed. The Fellow, Dr Mark Cuthbert, shows exceptional promise in becoming a leading scholar demonstrated by a wide range of publications in highly ranked journals, involvement in collaborative research projects, and strong leadership and project management skills. He will be based for the first 2 years of the Fellowship at the University of NSW, focusing mainly on field aspects of the research and training. He will benefit from working with internationally leading scholars in GSI research and have access to a unique range of world-class equipment, catchment infrastructure and technical expertise. Returning to the EU to work with the University of Birmingham, modelling components of the research will be developed, supported by the facilities and groundwater-surface water expertise within the internationally excellent Water Sciences research group. In addition to the fundamental scientific research, the Fellow will receive training in a range of field, analytical and modelling techniques as well as complementary research skills. The Fellowship will enable him to fulfil his goal of becoming a leading researcher in near-surface hydrogeology, based within an EU university and strengthen European competiveness in this area.

Keywords: hydrology (water science),integrated management of water,water system modelling,hydrogeology (geophysics)