Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Real-time nanoscale manipulation of structure and environment to understand light-harvesting regulation in photosynthesis (MARIONETTE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 2174716.0
EU funding (EUR): 2174716.0
Participants: 1
Project status: SIGNED

Sunlight is a source of life for plants but also of photodamage. To harvest solar energy “safely”, plants have developed a nanoscale mechanism controlled by small proteins which bind pigments, called light-harvesting complexes (LHCs). At low light intensities, the LHCs harvest and transport solar energy to the sites of photochemistry. Under intense light, LHCs switch function to dissipate excess energy as heat. Through this photoprotective switch, the LHCs efficiently protect plants from photodamage. Yet, how do plants activate the LHC photoprotective switch? Current models assume that the switch is driven by protein conformational changes of the LHCs, regulated by the environment through pH changes and interactions with protein and cofactors. However, no experimental tool implemented in the field of photosynthesis allows to identify the conformational changes responsible of photoprotection and to determine how the environment controls them – limiting our mechanistic understanding of light-harvesting regulation in plants. I will tackle this challenge by: 1) Pioneering the study of LHC nanomechanics via single-molecule optical tweezers, resolved in force and fluorescence, to track LHC conformational changes at single-residue level and identify those driving the photoprotective switch. 2) Leveraging a novel ultrafast multipulse spectroscopic tool — just developed by my group — to rapidly control environmental changes and determine the intermediate steps in the photoprotective switch of the LHCs. 3) Integrating ad hoc molecular dynamics simulations to map how external physiological factors tune the conformational landscape of the LHCs. By implementing a novel optical and computational toolkit, I will advance our understanding of how plants regulate light harvesting at the nanoscale, while establishing a new framework in photosynthesis and photobiology to determine how structure and environment control the function of photosensory proteins across all life domains.

Keywords: plant photoprotection light harvesting complex quenching ultrafast spectroscopy molecular dynamics single molecule optical tweezers
Organic's genesis on Mars (ORIGIM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,United States,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2029-02-28
Duration (months): 42.0
Total project cost (EUR): 473445.36
EU funding (EUR): 473445.36
Participants: 4
Project status: SIGNED

What is the origin of the organic molecules recently found on Mars? And the organics and dark rims of iron and phosphorus recently found by Perseverance? Could they have a biological origin? Are we closer to finding life beyond the Earth? These challenging questions form the basis of the ORganIc GenesIs on Mars (ORIGIM) project. Inspired by the exciting and recent discoveries of organic compounds and phosphorus on Mars and asteroids Benu and Ryugu, ORIGIM aims to constrain the geological and biological processes behind the different mineral and chemical signatures detected, which may hold the key to understanding the possibility of life beyond our planet. The ORIGIM project is interdisciplinary research between the NASA Goddard Space Flight Centre (GSFC, USA) and the Centre for Astrobiology (CAB, Spain). Fieldwork, geochemical and cosmochemical simulations, and real-time monitoring of NASA's Mars Science Laboratory and Mars2020 missions will involve leading biologists, geologists, chemists, physicists and engineers. ORIGIM aligns with the growing interest in detecting life beyond Earth, led by NASA and JAXA (Japan), and the upcoming ESA ExoMars and NASA-ESA Mars Sample Return (MSR) missions, which will position the European Union prominently in the space exploration arena. The ORIGIM project is timely and novel, as it will contribute to the challenging task of identifying biological vs non-biological signatures in extraterrestrial materials, ultimately addressing the long-standing question of whether life has ever existed beyond Earth. Dr. Cañadas will lead the project with a strong focus on international and interdisciplinary collaboration. The fellowship provides a unique opportunity for her to develop leadership skills in dynamic scientific environments, enhancing her geochemical expertise with new methodologies and personal growth. This will position her as a highly visible and independent EU scientist in the rapidly expanding field of Astrobiology

Keywords: mars,life,carbon,phosphorus
Multiomic DNA Chip Technology for Blood Cancer Profiling (MULTI-C)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-10-01
End date: 2027-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Blood cancers remain challenging to diagnose and monitor due to the standard of care requirement for bone marrow biopsies and limitations in current biomarker detection technologies. DNA modifications, specifically 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)—are powerful epigenetic regulators in blood cancer development, providing valuable diagnostic and prognostic information. Despite their clinical importance, current technologies fail to simultaneously detect both 5mC and 5hmC with precision and efficiency, creating a significant barrier to clinical implementation of these epigenetic marks. This proposal introduces an innovative microarray platform that overcomes these limitations by enabling simultaneous profiling of both 5mC and 5hmC modifications from blood samples within a single, cost-effective assay. Unlike current methods that struggle with modification differentiation, sample degradation, and complex workflows, our technology offers a streamlined approach that preserves sample integrity while delivering superior diagnostic accuracy. Our innovation lies in the ability to distinguish different cytosine modifications (MULTI-C), which provides significantly enhanced diagnostic accuracy compared to single-marker approaches. The platform's remarkable sensitivity allows detection from minimal DNA inputs, making it ideally suited for minimally-invasive liquid biopsy applications—a critical advancement for patient monitoring and precision medicine in hematological malignancies. This research has the potential to transform how blood cancers are diagnosed, monitored, and treated by addressing a fundamental technological gap in epigenetic profiling and reducing the need for bone marrow biopsies.
Role of Extracellular Polymeric Substances (EPS) in the prevalence and resilience of Lotmaria passim (ROLEPS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2026-04-30
Duration (months): 28.0
Total project cost (EUR): 169822.91
EU funding (EUR): 169822.91
Participants: 2
Project status: SIGNED

Lotmaria passim is a trypanosomatid parasite of bees, highly prevalent in honeybee colonies, considered a major factor in colony loss. Yet, the molecular mechanisms it uses to survive both inside and outside its host are unknown. Preliminary studies showed that L.passim secretes extracellular polymeric substances (EPS) and differentiates into surface attached colonies mimicking the mechanism of bacterial biofilm formation. EPS provides environmental resistance to changing and extreme physicochemical conditions (e.g. in bacteria). Thus, I hypothesise that EPS confers resistance to L.passim and have an active role in the bee gut. In ROLEPS I aim to explore the role of EPS secretion and the mechanisms of biofilm formation in the prevalence and resilience of L.passim chasing three objectives: i) study the response of L.passim biofilms to biotic and abiotic stressors, ii) identify the genes involved in EPS secretion and the developmental differentiation into biofilms using CRISPR/Cas9, and iii) explore the function of EPS in honey bee health. ROLEPS will be developed at the University of Granada (Spain), within the Biochemistry and Molecular Parasitology group lead by Prof. de Pablos, who has developed a protocol to isolate trypanosomatid strains from field isolates, optimized the isolation of the secretome of trypanosomatids and settled all the facilities for genetic engineering assays. A secondment is planned at the Centro de Investigación Apícola y Agroambiental (CIAPA) in Marchamalo (Spain), supervised by Dr. Higes, expert on bee health. ROLEPS is an innovative project as it will analyse for the first time the role of EPS and biofilms in a trypanosomatid parasite of bees, it will integrate genetic engineering in the field of bee parasitology and test parasite-secreting substances as protection against contaminants in bees. ROLEPS is fully achievable due to the easy handling of the model organisms. Thus, I expect ROLEPS has important repercussions in bee health.

Keywords: crispr cas9,trypanosomatids,biofilm,eps,honey bees,beekeeping,animal health
Chemical Engineering of Natural Killer Cells for Cancer Immunotherapy (CHEMCELL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Czechia
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2022-09-01
End date: 2024-02-29
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Our immune system evolved to protect our bodies from different invaders and to fight against infections and diseases. Immune cells use sophisticated ways to detect and destroy abnormal cells, while sparing our own cells. Unluckily, cancer cells often develop sneaky tricks enabling them to evade this protecting machinery and to survive and proliferate. Immunotherapy, an emerging concept of treatment, aims to employ the power of immune system to fight cancer by boosting or reeducation of immune cells. One of the approaches, the adoptive cell transfer therapy, especially in the form of chimeric antigen receptor (CAR) cells, has shown an unprecedented success in the treatment of certain types of cancer. CAR cells are genetically modified immune cells engineered to recognize and kill cells with specific cancer antigen. Unfortunately, production of genetically modified CARs is problematic, inefficient, time consuming and therefore, associated with high costs. New approaches enabling production of modified immune cells more effectively, faster and cheaper could therefore change the way the therapy is used. Within this proposal, we will explore the potential of an innovative approach for production of chemically engineered immune cells and their application in immunotherapy. In particular, we will employ our technology based on combination of metabolic engineering and subsequent biocompatible chemical labeling to produce an antibody modified natural killer (NK) cells that we will investigate in cancer killing experiments. We will perform a side-by-side comparison of our technology with the ‘traditional’ CAR-NK cells both, in vitro and in vivo, to evaluate the pros and cons of both approaches. Finally, in collaboration with our Tech Transfer Office, we will present the technology to potential stakeholders to bring it to the next step in the form of patent licensing or eventually, develop the technology further within spin-out company.
Advancing Technological Leap in the Area of floating offshore wind turbines Needed for a Transition to Innovative Clusters of green energy (ATLANTIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: France,Netherlands,Sweden,Germany,Norway,Greece
Call: Demonstrations of innovative floating wind concepts (HORIZON-CL5-2024-D3-02, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 20131184.75
EU funding (EUR): 14999582.38
Participants: 13
Project status: SIGNED

Floating wind is essential to reach climate neutrality and cement Europe’s leadership in renewables globally. While floating wind technology has been proven technically feasible through prototypes commissioned in the past few years, its industrialisation and competitiveness still need to be demonstrated. A key limitation of current floating wind projects is the lack of integrated optimisation between turbines and floats, which leads to higher CAPEX and hinders commercial viability. Additionally, the absence of a European industrialisation framework for large-scale production and deployment of floating offshore wind turbines presents a challenge. Standardising manufacturing processes and optimising logistics are critical to avoid bottlenecks by 2030. In this context, ATLANTIC aims to drive a breakthrough in the sector by providing a holistic design solution, addressing both technology and European supply chains. The project will demonstrate a disruptive 5 MW floating unit with a pyramidal design, connected to the grid at Le Croisic, France. It will create a pathway to reach a Levelised Cost of Energy (LCOE) of 85€/MWh by 2030 (and 57€/MWh beyond 2035) with a carbon footprint <16 gCO2eq/kWh. Over two years, extensive data monitoring from the pilot will allow for future optimisation of industry-scale commissioning, addressing performance, environmental considerations, and future harbour logistics. It will also lay the ground for establishing a European supply chain to enable the large-scale production of floating offshore wind farms and enhance EU sovereignty. To achieve this ambitious objective, the industry-driven consortium of ATLANTIC gathers 13 entities from 6 different countries, including 4 industries and SMEs, 1 public-interest foundation, 6 research centres, 1 university and 1 regional organisation.

Keywords: floating offshore wind turbine fowt,energy security,eu sovereignty,supply chain
Modernist Occupations: Time in the Work of Literary Imagination (TimeWorks)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 284179.68
EU funding (EUR): 284179.68
Participants: 3
Project status: SIGNED

TimeWorks explores the temporality of work in British and American modernist writing. Few scholars as yet have found it worthwhile to study representations of labor in modernism, assumed to be absorbed in subjectivity and form. At the same time, modernism’s formal inventions continue to inspire reflection on temporality. Temporal forms, Timeworks argues, present a key to the problem of work in modernism as work relates fundamentally to the social organization of time. Modernist preoccupation with the writer’s occupation, in quest of liberated ways of living time, offers a critical lens on the socio-temporality of work at a moment of historic transformation in social divisions of labor. This action proposes the first sustained study of modernist work and time, examining modernist treatments of the writer’s time with due attention to dimensions of class, gender, and race. This goal calls for a new approach to social time, shifting focus from the diachronic axis of past-present-future to the interplay of synchronous temporal forms. Modernist temporal experiments thereby inspire study of the socio-temporalities of work in literature and culture more broadly: a new humanities-based approach to the socio-economic question of labor shows how aesthetic engagements can illuminate the role of work in organizing social time. The MSCA positions the researcher at the leading edge of emergent research on modernist work, with the aim of leading larger projects on the socio-temporality of work in literature and culture. Training vital to this career path is enabled by the “Temporal Experiments” group at the University of Oslo, specializing in the aesthetic study of temporal forms, and the leading modernist milieu at the University of Pennsylvania home to many scholars working on economic topics in literature and culture. Secondment to Bard College offers further expert supervision and the unique chance to contribute editorially to the field’s foremost journal Modernism/modernity.

Keywords: english literature,modernism,british and american modernism,time temporality,representations of work labor
SECURE AND SUSTAINABLE SUPPLY OF RAW MATERIALS FOR EU INDUSTRY (S34I)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Portugal,Italy,Spain,Romania,Germany,Belgium,Finland,Austria,Slovenia,Ireland,Greece
Call: Earth observation technologies for the mining life cycle in support of EU autonomy and transition to a climate-neutral economy (RIA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2023-01-01
End date: 2025-06-30
Duration (months): 30.0
Total project cost (EUR): 4498607.75
EU funding (EUR): 4498607.75
Participants: 20
Project status: CLOSED

S34I will research and innovate new data-driven methods to analyse Earth Observation (EO) data, supporting systematic mineral exploration and continuous monitoring of extraction, closure and post-closure activities with the aim to increase European knowledge and autonomy on raw materials resources. S34I uses EO not only for the management of technical and environmental issues for a green transition but also to support mining's social acceptance (SLO) and better legislation. Innovative EO-based products/services will provide new or more accurate RM mineral mapping/exploration, environmental and mine monitoring and mine safety, at different phases of the mine life cycle. S34I will exploit Copernicus and other satellite sensors (optical and radar), while other platforms as airborne, low-altitude platforms, ground-based, in-situ techniques/methods, and fieldwork will serve either for calibration, validation or to complement Copernicus data especially at the very high scale spatial or spectral resolution. S34I will provide 6 new open high added value datasets, 14 new methods to analyze EO data using Artificial Intelligence being utilized at different phases of the mining life cycle, 3 new prototyped EO based services for mining stakeholders, 1 research and innovation agenda on EO for mining, a set of recommendations for better policy, and guidelines for EO uptake by the mining industry. S34I results will be validated at six different locations in different phases of the mining life-cycle: (i) land exploration in Spain; (ii) coastal exploration at the Iberian Peninsula Atlantic coast; iii) extraction phase in Austria and; iv) closure/post-closure phase in Finland and Germany. S34I is an EU wide interdisciplinary and complementary team embracing partners from 11 countries and with a 50/50 balance between industrial and research profiles. S34I mining stakeholders will lead the path towards mining de-carbonization while creating social and economic impact through EO uptake.

Keywords: ree,cobalt,land and coastal exploration,extraction,closure post closure,eo,raw materials secure and autonomous supply,sustainable mining,digital and green transformation,responsible ai,slo
Signalling of Minor Pocket Agonists at CXCR4 (SMiPAX4)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2025-02-28
Duration (months): 30.0
Total project cost (EUR): 244893.6
EU funding (EUR): 244893.6
Participants: 3
Project status: CLOSED

The following project, SMiPAX4, conducted in the academic group of Jean-Philippe Herbeuval (Univeristy of Paris, France), is at the cross section of immunology and pharmacology. Moreover, due to its direct application potential and the subsequent industrial placement to deepen the acquired knowledge at Sanofi it is also cross sectional between academia and industry. The main objective of the project is to understand the mode of action of small molecules, functionally causing a reduction of immune response, binding into the minor binding pocket of the G protein coupled receptor CXCR4. The signalling cascade as well as the implication of different expression levels of the target CXCR4 will be explored through different biochemical techniques. Protein-protein interactions will be identified using Bioluminescence energy transfer (BRET) techniques, increase or decrease of second messenger molecules will be identified using biosensors, and phosphorylation states, up- or downregulation of (signalling) proteins will be measured using flow cytometry or western blotting. Inflammation of cells when controlling the impact of silencing certain signalling molecules will be controlled by measuring the levels of inflammation markers. Due to the projects implication in (auto)immune and other inflammation diseases it is relevant for cluster 1, Health, of the Horizon Europe programme. The project shows great potential in the area of impact due to its unique target potentially helping people that do not respond well to already approved medication. Both, the dissemination of results producing multiple publications in peer reviewed journals, talks and posters at scientific meetings as well as the potential of creating market within the EU are very probable with completion of this project.

Keywords: gpcr g protein coupled receptor,bret bioluminescence resonance energy transfer