Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Growing bone fast and cost-effective (CHARME)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Netherlands
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 2630845.0
EU funding (EUR): 1841591.0
Participants: 1
Project status: CLOSED

XPAND Biotechnology BV has developed a new generation of orthopaedic materials: the EpitaxOs bone regeneration material. EpitaxOs (TRL 6) is unique: a) it seduces the body to form bone b) is as effective as the golden standard autograft without its disadvantages (extra operative procedure, pain, limited quantity available) c) it is superior to other synthetic bone graft materials, allograft, growth factors and cell-based technologies d) it is available in abundant quantities e) it increases the quality of life for patients as the use of EpitaxOs has no adverse effects on the patient. The innovative property of EpitaxOs is its patented surface nano-structure, which induces the formation of bone by attracting the patient’s own stem cells to the defect site and stimulate them to make autologous bone (in situ bone tissue regeneration). Similar to autograft and growth factors and unlike other synthetic materials, EpitaxOs is a true bone inducing material, but generates bone much faster EpitaxOs is targeted at the €4 billion spinal market and the €200 million dental market. The exceptional bone inducing properties of EpitaxOs put it in a unique position to replace autograft, (processed) allograft and growth factors. The CHARME project aims at bringing EpitaxOs from technological maturity level TRL6 to a successful commercial/ production launch at level TRL 8/9 (in 2017). The objectives are: 1. Development of a commercial scale production infrastructure 2. Regulatory submission of EpitaxOs in key markets 3. Providing evidence-based data to demonstrate product superiority and facilitate product launch & market acceptance 4. Establishment of a marketing channel and development of a strategy for commercialisation of EpitaxOs The endpoints of the CHARME project will be EpitaxO, a commercial scale infrastructure, to manufacture EpitaxOs, regulatory submission, approval in Europe, clinically relevant study data, a marketing channel, plan for the commercialisation

Keywords: osteoinductive,bone growth,replacing golden standard autograft
Next Steps in Cosmology with CMB Spectral Distortions (CMBSPEC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 1965170.98
EU funding (EUR): 1965170.98
Participants: 1
Project status: SIGNED

The average spectrum of the cosmic microwave background (CMB) has long been known to be extremely close to a perfect blackbody. Yet, several processes, standard and non-standard, exist that may cause deviations from a blackbody spectrum, commonly referred to as CMB spectral distortions. Classical distortion shapes are known as Compton-y and chemical potential (µ-type) distortions; however, recently it has been shown that more general distortions can be created at redshifts 10^4 < z < 3×10^5. This makes spectral distortions a unique and powerful probe of different early-universe processes. The immense potential of CMB spectral distortion measurements and their synergies with upcoming CMB anisotropy studies (Litebird, COrE+, Stage-IV CMB) has identified them as an important future target, with several innovative experimental concepts (e.g., PIXIE, APSERa) being actively discussed by the cosmology community. This proposal has one main goal: to transform the emerging field of CMB spectral distortions into a mature scientific discipline. The team will significantly expand and strengthen the spectral distortion science case with particular emphasis on novel time-dependent information from the recombination era (10^3 < z < 10^4) and various photon injection processes. By combining all available information, we will investigate what spectral distortions could teach us about early-universe physics and the cosmological ionization history. Novel foreground parameterizations and experimental setups will be studied and simulation pipelines will be developed. Our work could deliver new tests for inflation, reionization and particle physics as well as extend our ability to distinguish sources of different distortion signals in the presence of foregrounds. We will identify novel spectral distortion science goals that will drive the experimental designs of future CMB spectroscopy experiments, pioneering and facilitating spectral distortion activities in Europe and worldwide.

Keywords: cosmic microwave background,spectral distortions,cosmological recombination
A High-Sensitive Green Localization System for High-Speed Self-Driving Vehicles (GREENLOC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-01
End date: 2019-08-14
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

Among the main goals of Intelligent Transportation Systems are (i) safety: reducing threats encountered due to human impact, and (ii) efficiency: providing transportation opportunities in an ecologically and economically sustainable way. Self-driving vehicles (SDV) have the potential to achieve both goals, for which localization (i.e., the determination of the positon and velocity of the vehicle) is of key importance. Localization is challenging due to the variety of conditions (weather, clutter, obstructions) that may impede different sensors, as well as the strict latency requirements. Accurate and fast localization is a necessity for providing crash-safe high-speed SDVs. Furthermore, reducing energy costs introduced by the continuous localization process is required for reducing the frequency to charge an SDV. Current SDV localization technology is insufficient in meeting these three performance measures at the same time, requiring a different approach for high-speed SDVs. This project proposes a high-sensitive fast green relative localization system, called as GREENLOC, which obtains and shares the relative location of surrounding vehicles and road-side units by ultra-wideband cross-layer communications in a multi-hop vehicular ad-hoc network. GREENLOC is the first localization system, which enables crash-safe SDVs driving not only on highways close to speed limits, but also in congested low-speed traffic. Moreover, GREENLOC is the first localization method that works accurately even in difficult weather conditions. This project has the potential to shift Europe forward in the international competitive race of SDVs, making crash-safe high-speed SDVs possible, which in turn has the potential to solve the traffic congestion problem. Besides, this fellowship is an excellent opportunity for the experienced researcher, who is enthusiastic about realizing her idea in an international research environment after a long period of parental leave dedicated to her family.

Keywords: ultra wideband localization,self driving vehicles,vanet,routing protocol
Transmitting Contentious Cultural Heritages with the Arts: From Intervention to Co-Production (TRACES)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Austria,Austria,Switzerland,Norway,Poland,Romania,Slovenia,United Kingdom,United Kingdom
Call: Emergence and transmission of European cultural heritage and Europeanisation (H2020-REFLECTIVE-SOCIETY-2015, 2015)
Start date: 2016-03-01
End date: 2019-02-28
Duration (months): 36.0
Total project cost (EUR): 2711052.5
EU funding (EUR): 2303358.75
Participants: 11
Project status: CLOSED

Transmitting Contentious Cultural Heritages with the Arts: From Intervention to Co-Production (TRACES) aims to provide new directions for cultural heritage institutions to contribute productively to evolving European identity and reflexive Europeanization. To do so, it deploys an innovative ethnographic/artistic approach, focused on a wide range of types of ‘contentious heritage.’ Attention to contentious heritage is crucial as it is especially likely to raise barriers to inclusivity and convivial relations, as well as to be difficult to transmit to the public. Transmitted effectively, however, it is potentially especially productive in raising critical reflection and contributing to reflexive Europeanization, in which European identity is shaped by self-awareness and on-going critical reflection. Through rigorous and creative in-depth artistic/ethnographic research, TRACES will provide a systematic analysis of the challenges and opportunities raised by transmitting contentious, awkward and difficult pasts. It will do so by setting up Creative Co-Productions (CCPs) in which artists, researchers, heritage agencies and stakeholders work together in longer term engagements to collaboratively research selected cases of contentious heritage and develop new participatory public interfaces. These will be documented and analysed, including educational research. These interfaces, which include online as well as physical exhibitions and other formats, are part of the significant output planned for TRACES, along with academic publications and a novel reflective Contentious Heritage Manual that will synthesise results to provide directions for future practical reflexive transmission of cultural heritage in Europe. TRACES is a multi-disciplinary team, bringing together established and emerging scholars, and providing high-level expertise, relevant experience and creative energy, to provide a rigorous and innovative approach to the transmission of European cultural heritage.

Keywords: contentious heritage s,contentious collections,creative co production,art based research,contested identity,contested memory,social aesthetizaton,heritage transmission,everyday agency
Novel Smart Motorcycle helmet with integrated health monitoring system, accident detection and eCall compliance. (NZi-VITAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-05-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

NZi-Vital is the first smart helmet for powered two wheelers integrating a vital sign monitoring and accident detection system capable of automatically contacting emergency services in the event of an accident, and providing accurate and valuable information (position, heart rate), without the need of human interaction. The eCall (emergency call) is performed through an APP previously installed in the user´s smartphone, which also warns the rider in case of bad health conditions. This APP allows real-time monitoring and post-ride analysis by the user. The system incorporates an audio communication module (headphones and microphone) to provide a direct voice channel with the emergency staff. So as to ensure a maximum reliability, it includes a wind power generator that, on average, generates enough energy for the whole system. 125c.c. and above motorcycle users comprise the target market of the NZi-VITAL helmet, since they will maximise the benefits of eCall (reduction of fatalities and severe injuries in roads) compared with more urban oriented vehicles. NZi-VITAL will promote the implementation of reliable eCall systems in powered two wheelers. eCall is estimated to achieve 7,5% fewer fatalities and 6% fewer hospitalisation of 1 or more days(1). This project will therefore support some EU initiatives adopted to reduce the number of deaths on Europe’s roads, such as the 2011 White Paper and the European Road Safety Policy Orientations 2011-2020. During this phase1, a comprehensive investor-ready feasibility study of the NZi-Vital will be drawn so as to guarantee the technical and commercial viability of the project and as well as building up the technical plan for phase2. Preliminary market projections shows a Return on Investment of 3.4 for the first five years of commercialization of the NZi-Vital helmet and revenues of €3 million. (1) According to Public Consultations Report: Deployment of In-Vehicle Emergency Call In EUROPE.

Keywords: enhanced ecall,embedded safety system,active safety for motorcycle riders,helmets,garments,health monitoring,automatic accident detection,automatic health hazards detection,off line ride data
Optical point of care system for heart failure mass screening (COSMOS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-04
End date: 2018-08-23
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Diseases of the heart and circulatory system are the main cause of death in Europe (over 4 million deaths each year). In particular, heart failure (HF) accounts for almost 1.1 million deaths each year. In early ’90 there was the formal recognition that inflammatory mediators are activated in the setting of HF by a sentinel description of inflammatory cytokines in patients with heart failure. After that, a growing interest in the role of biomarkers in regulating cardiac structure and function, particularly regarding their potential role in disease progression in heart failure, raised up. Nowadays, there are evidences on that. Generally, biomarkers are determined mostly in plasma or in blood, rather than in saliva. In fact, despite of that very few of them have been currently studied in saliva, saliva has to be considered as an important diagnostic and prognostic medium for minimally invasive tools. Indeed a great progress in disclosing the complete salivary proteome has carried to the identification of more than 3000 different proteins. Scope of this project is to develop a tool for HF-biomarkers detection through saliva. The idea is to combine the knowledge of the experienced researcher in microelectronics and CMOS imagers with the competences of the hosting laboratory on bioMEMs for biomarkers immobilization to develop an innovative point-of-care system for a fast and precise detection of HF-biomarkers. To this end the hosting institution and the experienced researcher complete each other and make the research and development on this cross related filed feasible. The proposed device will allow a mass screening for the prevention of HF and other pathologies related to the cardiovascular system. Within this project, the experienced researcher will be able both to enlarge her knowledge in the design of CMOS imagers by implementing innovative photon detection techniques and to approach a growing branch of microelectronics, such as the bioMEMs one.

Keywords: biomems,optial readout,point of care
Spatio-temporal Organization and Expression of the Genome (4D-GenEx)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-04-01
End date: 2025-03-31
Duration (months): 84.0
Total project cost (EUR): 1499750.0
EU funding (EUR): 1499750.0
Participants: 1
Project status: SIGNED

This project investigates the two-way relationship between spatio-temporal genome organization and coordinated gene regulation, through an approach at the interface between physics, computer science and biology. In the nucleus, preferred positions are observed from chromosomes to single genes, in relation to normal and pathological cellular states. Evidence indicates a complex spatio-temporal coupling between co-regulated genes: e.g. certain genes cluster spatially when responding to similar factors and transcriptional noise patterns suggest domain-wide mechanisms. Yet, no individual experiment allows probing transcriptional coordination in 4 dimensions (FISH, live locus tracking, Hi-C...). Interpreting such data also critically requires theory (stochastic processes, statistical physics…). A lack of appropriate experimental/analytical approaches is impairing our understanding of the 4D genome. Our proposal combines cutting-edge single-molecule imaging, signal-theory data analysis and physical modeling to study how genes coordinate in space and time in a single nucleus. Our objectives are to understand (a) competition/recycling of shared resources between genes within subnuclear compartments, (b) how enhancers communicate with genes domain-wide, and (c) the role of local conformational dynamics and supercoiling in gene co-regulation. Our organizing hypothesis is that, by acting on their microenvironment, genes shape their co-expression with other genes. Building upon my expertise, we will use dual-color MS2/PP7 RNA labeling to visualize for the first time transcription and motion of pairs of hormone-responsive genes in real time. With our innovative signal analysis tools, we will extract spatio-temporal signatures of underlying processes, which we will investigate with stochastic modeling and validate through experimental perturbations. We expect to uncover how the functional organization of the linear genome relates to its physical properties and dynamics in 4D.

Keywords: nuclear compartments,chromatin conformation,enhancer,dna topology,gene regulation,transcriptional noise,single molecule microscopy,rna imaging,stochastic modeling,statistical physics
High Performance and Embedded Architecture and Compilation (HiPEAC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Germany,Italy,Spain,Spain,Sweden,Greece,Belgium,France,France,France,Netherlands,United Kingdom,United Kingdom
Call: Customised and low energy computing (including Low power processor technologies) (H2020-ICT-2017-1, 2017)
Start date: 2017-12-01
End date: 2020-02-29
Duration (months): 27.0
Total project cost (EUR): 2600000.0
EU funding (EUR): 2000000.0
Participants: 13
Project status: CLOSED

HiPEAC is a coordination and support action (CSA) that aims to structure and connect the European academic and industrial research and innovation communities in computing systems (i) by increasing the industrial membership, (ii) by integrating the European innovation community, (iii) by organising activities to connect the research and innovation communities, (iv) by stimulating collaborations, (v) by producing a vision document on the future of computing systems in Europe, and (vi) by professionally disseminating the research outcomes in and beyond the European computing systems community. The HiPEAC CSA is meant to be the continuation of four successful networks with the same name (HiPEAC1-4). HiPEAC will leverage the existing community, the expertise and the set of instruments that were developed since 2004 and work on the following objectives: structuring and connecting the European computing systems community, cross-sectorial industrial platform-building, constituency building and consultations, clustering of related research and innovation projects, and road-mapping for future research and innovation agendas. The overall approach of the HiPEAC CSA is that it wants to bring together all actors and stakeholders in the computing systems community in Europe – especially EU-funded projects, SMEs and the innovation community – in one well-managed structure where they can interact, disseminate/share information, transfer knowledge/technology, exchange human resources, think about future challenges, experiment with ideas to strengthen the community, etc. The HiPEAC CSA will support its members and projects with tasks that are too difficult/complex to carry out individually: vision building, professional communications, recruitment, event management at the European level. By offering such services, a burden is taken away from the projects and members. They can then focus on the content, and the impact of their efforts is amplified.

Keywords: cyber physical systems,computer architecture,system software
The role of genetic redundancy in adaptive evolution of efflux pumps (EGR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

In genetic redundancy, multiple genes in a genome perform the same or similar function. Although redundancy is widespread across the tree of life, its evolutionary origins are not entirely understood. Genetic redundancy may provide a fitness benefit during evolution by increasing gene dosage and protecting critical genes from deleterious mutations. These fitness effects have been confirmed experimentally, but their long-term consequences for evolution have not been tested. In this study, I will manipulate the genomic content of efflux pump genes in E. coli and test the effect of their redundancy using directed evolution of proteins. By evolving the multidrug efflux pump AcrAB at different levels of redundancy, I will determine how the presence of other genes with overlapping drug-efflux activities affects adaptive evolution. I will compare evolutionary trajectories using comprehensive sequence and fitness analysis of the evolved efflux pump variants. This approach will provide a unique opportunity to directly test the role of genetic redundancy in evolution and help to understand why genetic redundancy is maintained in a genome.

Keywords: genetic redundancy,efflux pumps,antimicrobial resistance,gene duplication,directed evolution of proteins