Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A new CCU composite structure with a novel demountable connection towards CO2 sequestration and material recyclability. (CCU Structure)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Finland,Hong Kong
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 2
Project status: SIGNED

Carbon Capture and Utilization (CCU) is receiving increasing interest due to the continuously increasing CO2 emission, where one pathway is to mineralize carbon in concrete building material. Compared with Portland cement, reactive magnesia cement (RMC) has the potential advantage of higher CO2 sequestration during early age curing and its service life. Still, the inadequate carbonation depth limits its application. Another approach to reducing carbon emissions is recycling and reusing components in construction. The key to realizing component reuse and concrete material recycling is the proper demountable connection. However, the sudden slippage and labor-consuming problems of bolts were reported and might hinder the popularity of reusable structures. Therefore, this project will introduce hollow natural fibers (HNFs) with large lumens to enhance CO2 penetration and overcome the carbonation depth limitation. The participants will co-develop a mix design of HNF-reinforced RMC-based concrete that achieves a compressive strength of 50 MPa and a one-way carbonation depth of 60 mm. Besides, a novel demountable bolt-wedge system for dowel-based connectors will be proposed to realize excellent mechanical behavior and efficient construction of CCU composite structures. The shear behavior of the demountable connectors with the bolt-wedge system will be investigated by conducting push-out tests and finite element modelling. For the scientific community, the mix design will provide a solution for CCU structures, and the bolt-wedge system may initiate new research on prefabricated and reusable structures. Regarding societal and economic impacts, the proposed CCU composite structure could reduce emissions by CO2 sequestration and lower the net costs of reducing emissions due to the enormous scale of infrastructure. Reusing structural elements after their first design can decrease construction time and material costs. This project is in line with the "European Green Deal" goals.

Keywords: composite structures carbon capture and utilization reuse and recycle shear connectors demountable connection
Symbolic artificial intelligence for hidden topological orders in quantum physics (SymPhysAI)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Poland
Call: ERA Fellowships (HORIZON-WIDERA-2023-TALENTS-02, 2023)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 139953.6
EU funding (EUR): 139953.6
Participants: 1
Project status: SIGNED

Artificial intelligence (AI) offers novel methodologies to unravel complex physical phenomena. However, most machine learning models lack transparency in their decision-making processes. In this proposal, we aim to develop a symbolic AI as a tool to reveal hidden topological orders in quantum physics. To this end, an AI-assisted symbolic regression method will be studied. We focus on three main objectives: (i) machine learning topological phases with experimental data; (ii) uncovering hidden non-local symmetry-protected topological orders; and (iii) searching for quantized topological invariants in an unsupervised fashion. The interplay between symbolic AI and quantum physics is envisioned to bring new insights into topological phases. Moreover, the project will scrutinize the explainability and the robustness of machine learning models. The investigations will provide concrete guidelines for accompanying theoretical and experimental studies at MagTop. The outcomes of the project will pave the way to discover novel features of topological materials in a reliable and explainable way, as well as provide great opportunities for me to reach a position of professional excellence and independence.

Keywords: symbolic regression topological orders quantum machine learning
A breakthrough electrochemical climate technology for removing atmospheric CO2 at gigatonne-scale by harnessing the vast potential of the oceans (SeaO2)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Climate change is an urgent and escalating threat, driven by increasing CO2 emissions. In 2023, the global average atmospheric CO2 reached a record high of 419.3 parts per million (ppm), with a concerning increase of 2.8 ppm between 2022 and 2023. As emissions continue to rise, the window for preventing dangerous global warming is closing rapidly. To prevent 1.5°C of warming, GHG emissions must be reduced to about 31 Gt/year by 2030—a nearly 50% reduction in just eight years. Achieving this solely through emission reductions is unrealistic, making Carbon Dioxide Removal (CDR) essential for reaching Net Zero. Our innovative approach to CDR leverages the ocean's natural capacity to absorb CO2 through our patent-pending Direct Ocean Capture (DOC) technology. Oceans, which absorb 33% of all CO2 emissions and contain 150 times the carbon concentration of air, offer a more efficient and scalable solution compared to existing methods like Direct Air Capture (DAC). Our DOC technology, which requires only seawater and electricity, significantly reduces operational costs and energy consumption, facilitating large-scale implementation. Unlike DAC, it integrates seamlessly with existing infrastructure, such as abandoned oil and gas platforms, and can be powered by intermittent renewable energy sources like wind and solar. By producing high-quality carbon credits and supplying green CO2 for industrial applications, our solution addresses the urgent need for effective carbon removal and supports the decarbonisation of hard-to-abate sectors. We are committed to removing 1 gigatonne (Gt) of CO2 from the atmosphere by 2045, a crucial milestone for becoming a global leader in the carbon capture market and for the world to start removing 10 GtCO2 annually by 2050 to reach Net Zero.

Keywords: direct ocean capture doc,co2 removal cdr,electrochemical capture and conversion of co2,negative emission technologies nets
Reskube: A resilient foundation for edge computing - A simple, scalable and remotely managed device ensuring power, internet and computing stability for diversified organisations (Reskube Hub)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 18.0
Total project cost (EUR): 804229.0
EU funding (EUR): 804229.0
Participants: 1
Project status: SIGNED

Reskube Hub is revolutionary infrastructure technology designed to cater to broad commercial and social use cases enabling the benefit of advances in AI, 5G and IoT by acting as a solid foundation for the growth of distributed computing at the edge of networks (Edge Computing). Guaranteeing uninterrupted operations, Reskube Hub will serve as a platform for network optimisation and applications, bringing data processing and content delivery closer to end users, which improves performance and reduces latency. Simple to deploy and to remotely manage, this innovative system will provide easily distributed reliable power and connectivity infrastructure giving organisations confidence that the critical systems the deploy to the edge will continue to deliver their considerable value even when power, internet or devices fail. Reskube Hub will also integrate a computer platform capable of hosting virtualised network and application functions, including AI, making it more advanced than its predecessors and its competitors. With these capabilities all in one, Reskube Hub in effect delivers a Nano-Datacenter, removing the need for multi-device deployments with their associated challenges, complexities and costs. This simplicity streamlines operational delivery reducing the TCO of distributed systems and ensures continuous operation, visibility and control so improving the Return in Investment.

Keywords: reskube,edge computing,uninterruptible power supply ups,remote management,power storage,internet stability,innovation,network infrastructure,sustainable development goals sdgs,resilience
Mapping the axolotl brain and its regeneration (AxoBrain)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Switzerland,Germany,Austria
Call: ERC Synergy Grants (ERC-2023-SyG, 2023)
Start date: 2024-04-01
End date: 2030-03-31
Duration (months): 72.0
Total project cost (EUR): 8940901.0
EU funding (EUR): 8940901.0
Participants: 3
Project status: SIGNED

The Axolotl is an extraordinary model system to study regeneration in tetrapods. Remarkably, the axolotl is able to regenerate parts of the brain after major injury, however the molecular mechanisms that orchestrate regeneration are unclear, and the completeness of functional circuit and behavioral recovery is unknown. Our vision is to develop the axolotl model system to rigorously study central nervous system regeneration, and use discoveries from the axolotl to design novel strategies for regenerating mammalian tissues. The mapping of brain cell types and connections in the axolotl will also have a profound impact on the understanding of vertebrate brain organization and evolution. In AxoBrain, we will integrate scale-crossing technologies to map the axolotl brain at molecular, cellular and circuit resolution, and establish assays to understand how brain cells respond to damage and behavioral circuits regenerate. Our project will be achieved through the following objectives: 1) We will generate a spatiotemporal multiomic atlas of the axolotl brain at single cell resolution. 2) We will generate a connectome of the axolotl retino-tectal-hindbrain circuit and develop behavioral and circuit functional assays in response to visual stimulation. 3) We will establish injury assays and assess regeneration through behavioral, connectomic and single-cell multiomic analysis. 4) Finally, we will apply CRISPR perturbation screens with single-cell genomic readout in vivo and in vitro to identify modulators of regeneration. AxoBrain utilizes quantitative and state-of-the-art methods to explore how the axolotl can regenerate neural circuitry after injury. We have assembled a team with synergistic skill sets that will be required to achieve our vision. This project is a groundbreaking starting point to rigorously investigate how mammals have lost regeneration capabilities over evolution, and will serve as a springboard to design novel strategies for regenerating

Keywords: brain regeneration,salamander,single cell genomics,spatial transcriptomics,single cell crispr perturbation screen,organoids,connectomics
Smart Textiles made from Agriculture and Natural Waste Materials (SMARTWASTE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Türkiye,United Kingdom,Netherlands,Poland,Italy,Germany
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 1013314.29
EU funding (EUR): 869400.0
Participants: 11
Project status: SIGNED

The main objective of the SMARTWASTE MSCA SE project is to form a world class international and inter-sectoral network of organizations, working on a joint research programme in the field of novel Sustainable Smart Textile Materials, by replacing conventional and high costs textile materials with sustainable, environmentally friendly, cheaper and novel materials such as cellulose fibres from tomato stems waste and creating nonwovens from unconventional poplar seed fibers. This can only be achieved by bringing together world-class experts in materials, polymers, environmentalists, chemists, software engineers, and designers with state-of-the-art innovations and processes in their respective fields of expertise. The participants will exchange skills and knowledge to create sustainable textile materials, strengthening collaborative research between different countries and sectors. SMARTWASTE will also refine and produce potential commercial market opportunities for non-academic participants in the project (WP7). Our goal is to train next generation of researchers and innovators in sustainable textiles through cross-sectoral and training modules. The staff members will develop new skills, be exposed to new research and innovation environments, international networks, new industrial processes and techniques whilst widening and enriching career development through cross-sectoral knowledge transfer and international mobility.

Keywords: tomato fibre,sustainability,metal coating,conductive textiles,
Codasip High-end processor IP and high-level design tools for RISC-V (Codasip RISC-V Solution for High-end Processor IP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Czechia
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-11-01
End date: 2025-07-31
Duration (months): 33.0
Total project cost (EUR): 21523750.0
EU funding (EUR): 2499999.0
Participants: 2
Project status: SIGNED

Codasip offers a unique combination of semiconductor processor IP based on the RISC-V open instruction set architecture (ISA) and high-level EDA tool Codasip Studio providing outstanding flexibility and 5x faster time to market. RISC-V ISA can be used for a wide variety of applications ranging from low power and low gate count embedded cores to advanced high frequency application cores. We are extending our portfolio of IP cores to include high-end high-performance compute area, complementing our cores that cover the power efficient embedded and mid range compute area: a new generation of advanced core with a 9-stage pipeline with out-of -order superscalar architecture called A90. The release of A90 will lead towards the A110 core with heavily speculative execution and an 11-stage pipeline. The design of these cores will simultaneously trigger a release of Codasip Studio processor design tool for high-end compute, including advanced features like support of out of order architectures.

Keywords: 5g,artificial intelligence,processor ip,risc v,microarchitecture,electronic design innovation,advanced computing,electronic design automation,internet of things,high performance computing
Single-molecule profiling of full-length Tau isoforms and phosphorylated proteoforms (SPoTIP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Abnormal post-translational modifications (PTMs) can lead to the aggregation of Tau proteins, which characterize a wide range of neurodegenerative diseases known as tauopathies. Some abnormal Tau proteins will be released into biological fluids, providing a chance for minimally- or non-invasive diagnosis. For Alzheimer's Disease (AD), site-specific phosphorylations and truncations are representative PTMs that have been proved as biomarkers for its early diagnosis and progression monitoring. To detect and quantify these abnormal Tau proteoforms, two methodologies—immunoassays and mass spectrometry (MS)—are frequently employed. However, both of them encounter significant challenges in clinical trials; immunoassays suffer from limited epitopes and false positive results, while MS involves a complicated and time-consuming workflow. Nanopore technology, distinguished by its capability of real-time single-molecule sensing, has shown great prospects in polypeptide analysis, potentially offering distinct advantages over the forementioned methods in clinical trials. Recent progress has been made to sense PTMs deep within full-length polypeptides. By leveraging the recent advances in nanopore technology and the development of numerous site-specific anti-Tau binders, this project aims to exploit a single-molecule toolkit for detecting Tau of varying lengths and clinically relevant phosphorylations across full-length Tau proteoforms. To achieve that, we will leverage engineered nanopores developed by the host lab to facilitate translocation of intact Tau proteoforms, alongside a binder-assisted strategy to amplify the signals of targeted truncations and phosphorylations while minimizing interference from non-target backgrounds. Should our goal accomplished, it could provide a sensitive and robust diagnostic tool for the assessment and monitoring of tauopathies, as well as contribute to the advancement of tauopathies research to single-molecular resolution.

Keywords: tau,single molecule,truncation,phosphorylation,nanopore,binder
Two-dimensional Dipolar Quantum Gases: Fluctuations and Orders. (2DDip)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-02-01
End date: 2027-01-31
Duration (months): 60.0
Total project cost (EUR): 1498500.0
EU funding (EUR): 1498500.0
Participants: 1
Project status: SIGNED

Ordering in two-dimensional (2D) worlds is fundamentally different from what we know in 3D: Thermal fluctuations preclude conventional long-range order. An unconventional ordering mechanism based on topological defects may occur. The resulting order is topological, remains fluctuating, and intimately depends on the interparticle interactions. Many systems, including frustrated magnets, superconductors, colloids, and quantum gases, exhibit such orders. Their topological origin confers them exotic properties, of high technological interest, yet still partly enigmatic. In ultracold Bose gases of magnetic atoms, short-range and long-range anisotropic dipolar interactions compete. Recently, such gases were observed to stabilize despite attractive mean interactions, through the effect of quantum fluctuations. This fueled the discovery of several new phases of matter in such 3D gases, a prominent example being supersolids, which show simultaneous superfluid and crystal orders. Building on my expertise in both fields, I propose to expand the rich physics of magnetic-gas orders to the exotic and yet unexplored 2D universe, in a new experimental setup. Due to the unique variety of orders featured in magnetic quantum gases – superfluid, crystal, plus their anisotropic features (orientational orders) – and their remarkable intertwining, an unprecedented playground for 2D topological ordering will be at hand. By exploring the phase diagram, I will aim to bring a deep understanding of ordering and reveal new quantum phases. First, I will focus on the repulsive regime and characterize the interplay between long-range anisotropic interactions and topological superfluidity. I will then explore the fluctuation-stabilized attractive regime. Here, I will map the novel variety of orders that 2D worlds provide. Focusing on their ordering mechanism will reveal unprecedented phenomena, such as topological supersolidity and (superfluid) liquid-crystals, opening new research avenues.

Keywords: many body quantum phenomena,quantum bose gases,dipole dipole interactions,phase transitions,two dimensional physics,topological order,topological defects,dysprosium
Breaking Barriers: Peripheral Immune Mechanisms in Early Parkinson's Disease (PRIME-PD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499921.0
EU funding (EUR): 1499921.0
Participants: 1
Project status: SIGNED

Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized by alpha-synuclein (α-Syn) aggregation. Despite being the fastest-growing neurodegenerative condition in terms of patients affected, there are currently no disease-modifying treatments and diagnosis typically occurs after significant neurodegeneration has already taken place. Intervening in the prodromal phase remains the critical challenge, and gaining a deeper understanding of the underlying pathophysiology is essential. Compelling evidence suggests that α-Syn might aggregate early in the enteric nervous system, spreading to the brain via the vagus nerve and triggering immune cell migration into the brain, where they contribute to disease progression. This project aims to address three key questions: 1) How are peripheral immune cells recruited to the brain in early α-Syn pathology? 2) How do peripheral immune cells interact with brain-resident cells to modulate the spread of α-Syn and neurodegeneration? 3) How do immune profile changes in the blood of high-risk prodromal PD patients relate to disease progression? To answer these questions, I will investigate the entry of peripheral immune cells to the brain using cutting-edge proximity and enzymatic labelling strategies; determine the immune interactome underlying α-Syn pathology and spread by combining α-Syn aggregation assays with in-situ spatial sequencing; and characterize circulating immune cells in prodromal PD patients by employing a humanized engraftment model to link peripheral immune phenotypes to disease progression in patients. By integrating these innovative techniques, this research aims to uncover how peripheral immune cells contribute to the onset and progression of PD, potentially identifying new biomarkers and therapeutic targets for early intervention. Modifying immune cells in the blood to modulate the brain's immune environment represents a major shift in treating PD as a multisystem neuroimmune disorder.

Keywords: parkinson s disease,myeloid cells