Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The European Nanotechnology Community Informatics Platform: Bridging data and disciplinary gaps for industry and regulators (NanoCommons) (NanoCommons)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Austria,Ireland,Austria,Germany,Spain,Germany,Germany,Cyprus,Greece,Switzerland,Slovenia,Netherlands,United States,United Kingdom,United Kingdom,United Kingdom
Call: Integrating Activities for Starting Communities (H2020-INFRAIA-2017-1-two-stage, 2017)
Start date: 2018-01-01
End date: 2022-06-30
Duration (months): 54.0
Total project cost (EUR): 5586000.46
EU funding (EUR): 5400000.0
Participants: 17
Project status: CLOSED

Nanotechnologies and the resulting novel and emerging materials (NEMs) represent major areas of investment and growth for the European economy. Recent advances have enabled confidence in the understanding of what constitutes toxicity of NEMs in relation to health and environmental hazards. However, the nanotechnology and nanosafety communities remain disparate and unconnected, whilst knowledge and data remain fragmented and inaccessible, such that from a data integrating and mining perspective it is clearly a “starting community”. The field, and indeed the European open knowledge economy, requires conversion of these scientific discoveries into legislative frameworks and industrial applications, which can only be achieved through concerted efforts to integrate, consolidate, annotate and facilitate access to the disparate datasets. NanoCommons brings together academia, industry and regulators to facilitate pooling and harmonising of methods and data for modelling, safe-by-design product development and regulatory approval purposes, thereby driving best practice and ensuring maximum access to data and tools. Networking Activities span community needs assessment through development of demonstration case studies (e.g. exemplar regulatory dossiers). Joint Research Activities will integrate existing resources and organise efficient curation, preservation and facilitate access to data/models. Transnational Access will focus on standardisation of data generation workflows across the disparate communities and establishment of a common access procedure for transnational and/or virtual access to the data, and modelling and risk prediction/management tools developed and integrated. Given the extremely rapid pace of development of nanoinformatics, NanoCommons’s detailed workplan will be prescribed for the first 18 months, beyond which it will be co-developed with stakeholders on a rolling call basis to ensure maximum responsiveness to community needs.

Keywords: nanosafety,nanoregulation,nanoinformatics,key enabling technology
Improving cold chain logistics with a temperature monitoring label (Svalinn)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Germany,Norway,Norway,United Kingdom
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2020)
Start date: 2021-02-01
End date: 2024-01-31
Duration (months): 36.0
Total project cost (EUR): 3490653.75
EU funding (EUR): 2443457.63
Participants: 4
Project status: SIGNED

The pharma and food logistics sectors lose sector lose €31.2bn and €27.6bn a year respectively through poor temperature control in the while in transport. Excessive heat or cold during transit can degrade pharmaceuticals or render them useless, and make highly perishable foods inedible or potentially hazardous for consumers. Logistics companies invest €33bn each year in IoT technologies for temperature monitoring. But current solutions still use costly and cumbersome data logging technologies, with limited or no data analytics capacity, low automation and irregular RFID communication. Svalinn is a automatic temperature logger for land, sea and air logistics. It gives a full temperature and geolocation log on each package or shipment from the start to the end of the transit, with programmable intervals and temperature alert thresholds.

Keywords: cold chain monitoring,multimodal logistics,iot technologies,cellular networks,printable temperature logger,food safety,pharma safety,automatic,customisable
dUTPase Signalling: from Phage to Eukaryotes (DUT-signal)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-12-01
End date: 2022-11-30
Duration (months): 84.0
Total project cost (EUR): 2246192.0
EU funding (EUR): 210000.0
Participants: 2
Project status: SIGNED

dUTPases (DUTs) are enzymes that regulate cellular dUTP levels to prevent the misincorporation of uracil into DNA. Recently however, DUTs have been involved in the control of relevant cellular processes. How these regulatory functions are controlled remains unsolved. The recent elucidation of the mechanistic role of DUTs in the transfer of staphylococcal pathogenicity islands (SaPIs) by our group has revealed an entirely novel and surprising strategy involving DUTs in signalling. Namely, we have demonstrated that in addition to the 5 classical domains present in all the trimeric DUTs, staphylococcal phage-encoded DUT proteins possess an extra region (Motif VI) involved in SaPI de-repression by binding to the SaPI-encoded repressor (Stl). Although this domain is necessary, it does not suffice to induce the SaPI cycle. Unexpectedly, the strongly conserved DUT motif V is also inherently involved in mediating de-repression. Crystallographic and mutagenic analyses have demonstrated that binding to dUTP orders the C-terminal motif V of phage-encoded DUTs, potentially rendering these proteins in the conformation required for SaPI de-repression. In contrast, conversion into the apo state conformation by the hydrolysis of the bound dUTP disorders motif V and generates a protein that is unable to induce the SaPI cycle. Analogously, previous work demonstrated that the trimeric rat DUT interacts with the transcriptional factor PPARα, an interaction that depends on an “extra” N-terminal motif VI present in the DUT protein and requires the C-terminal domain contribution, strongly supporting in general the mechanism involving DUTs in signalling. In summary, our results suggest that DUTs define a widespread family of signalling molecules that acts analogously to eukaryotic G-proteins. This project stems from this ground-breaking result, and will investigate the biological role of DUTs as signalling molecules, opening up the possibility to establish dUTP as a new second messenger.

Keywords: dutpase,signalling,dutp,bacteriophage,staphylococcus aureus,enterococcus,toxoplasma,plasmodium
A New Generation of Small Electric Motors: More Powerful, Smaller, Greener (FlexCoil)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Micromotors are small high-performance electric motors that fit in the palm of a hand. There are many applications that depend on micromotors: prosthetic arms, surgical robots or medical power tools. However, the micromotors currently in use were invented 40 years ago without any real innovation since then. This is about to change with the launch of the FlexCoil technology by Mirmex Motor. The core innovation consists of printing the motor winding (the part generating the magnetic force that creates the rotation) on a flexible PCB (printed circuit board) instead of manufacturing it out of copper wire. Once rolled tubularly, it enables novel winding geometries, currently impossible with conventional technology. This improves the performance of the micromotors in terms of compactness or efficiency. Mirmex Motor is a spin-off from the UCL (Université Catholique de Louvain) with an exclusive exploitation license on the technology. After 7 years of research, the IP is protected by 2 patent applications, the inventors being part of the company founding team. Discussions with important sectorial end-users have indicated a strong interest in high added-value industries such as the medical, aeronautical, aerospace and robotics sectors, representing a market potential over €1 billion. An illustrative example of the positive impact of FlexCoil on EU citizens is the development of better active prostheses that could change the lives of those who need them. Their weight and their autonomy drastically depend on the motor performance. This is a problem that we can solve! With this Phase 1 SME grant request, Mirmex Motor plans to further validate key hypothesis regarding the market size, the willingness to pay from the customers, and the manufacturing ramp-up requirements. The company should reach +€20M in revenues by 2024 based on the sales of windings (€5-€150) to system manufacturers and complete motors (€100-€600) to system integrators.

Keywords: micromotor,coil,flexible electronics,printed electronics
Personalized commercial practices and digital market manipulation: enhancing fairness in consumer protection (FairPersonalization)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2022-07-31
Duration (months): 18.0
Total project cost (EUR): 131679.36
EU funding (EUR): 131679.36
Participants: 1
Project status: CLOSED

Online commerce experienced a technological revolution, shifting towards automated, data-driven technologies for the allocation and display of offers and advertisings. Tailored and targeted commercial techniques constitute a heterogeneous phenomenon, incorporating ex multis semantics and data mining stemming from artificial intelligence, auction, social network, and neuroscience analyses, to reach different degrees of personalization. These innovations provide companies with new modes to gain market advantage and to offer their products: they have the possibility to study consumers and to personalize every aspect of their consumption experience. Consumers exposed to such potential situations could end up not being able to recognize the artificial reduction of their set of choices and, eventually, to oppose to it, being unaware of the way through which such messages utilize their habits, mental models and biases to influence their behaviours. The result of these and related trends is that firms can not only take advantage of a general understanding of cognitive limitations but also can uncover, and even trigger, consumer frailty at an individual level. I will a) investigate - by conducting online and laboratory experiments - how the use of online personalized and tailored offers affects the individual propensity to consume; b) redefine the normative thresholds and conditions under which tailored commercial practices should be qualified as unfair or manipulative under EU consumer law c) assess if, given the emergence of structural changes in consumption in the information society, it is still possible to hold up the idea that consumer protection can rely on its traditional theoretical notions and appraisal dynamics or if, on the contrary, these elements call for a substantial rethinking of the interplay between regulators, enterprises, and consumers.

Keywords: online commercial practices,personalization,tailored offers,consumer protection,behavioral and cognitive bias,unfair commercial practice directive
Imaging Functional Integration Of Newborn Neurons Into Neural Circuits Of The Axolotl Brain (Imagine)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-01
End date: 2024-02-29
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: SIGNED

Post embryonic growth and regeneration require new cells to integrate into the network of existing cells. In the case of the brain it is extremely important to maintain and restore circuit function, such that behaviors can be executed correctly. To study such processes a system that fulfills both post-embryonic growth as well as regeneration is needed. Furthermore, since neural circuit functions are highly dynamic the need for in vivo approaches is evident. In mammalian systems where neurogenesis occurs throughout life in restricted brain regions such approaches are technically challenging. Here, I propose to use the axolotl (Ambystoma mexicanum) brain to understand the dynamic remodeling of neural circuits through the addition of newborn neurons during post-embryonic growth and regeneration. I will establish a high resolution intra-vital in vivo imaging approach to address the dynamics of neurogenesis and remodeling of neural circuits in the telencephalon and the optic tectum. Using this setup in combination with genetically encoded calcium indicators I will generate activity maps of these regions in the presence or absence of defined stimuli and address their functional remodeling during growth and their restoration after injury. Furthermore, I will develop and adapt methods to visualize the functional connections of neurons in axolotl. Together, this work will provide fundamental insights into the functional maintenance and regeneration of neural circuits and the dynamics of how new neurons integrate in vivo which has not yet been achieved in any vertebrate system.

Keywords: regeneration,neurogenesis
The role of the virome in shaping the gut ecosystem during the first year of life (BabyVir)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2023-06-30
Duration (months): 75.0
Total project cost (EUR): 1499881.0
EU funding (EUR): 1499881.0
Participants: 1
Project status: SIGNED

The role of intestinal bacteria in human health and disease has been intensively studied; however the viral composition of the microbiome, the virome, remains largely unknown. As many of the viruses are bacteriophages, they are expected to be a major factor shaping the human microbiome. The dynamics of the virome during early life, its interaction with host and environmental factors, is likely to have profound effects on human physiology. Therefore it is extremely timely to study the virome in depth and on a wide scale. This ERC project aims at understanding how the gut virome develops during the first year of life and how that relates to the composition of the bacterial microbiome. In particular, we will determine which intrinsic and environmental factors, including genetics and the mother’s microbiome and diet, interact with the virome in shaping the early gut microbiome ecosystem. In a longitudinal study of 1,000 newborns followed at 7 time points from birth till age 12 months, I will investigate: (1) the composition and evolution of the virome and bacterial microbiome in the first year of life; (2) the role of factors coming from the mother and from the host genome on virome and bacterial microbiome development and their co-evolution; and (3) the role of environmental factors, like infectious diseases, vaccinations and diet habits, on establishing the virome and overall microbiome composition during the first year of life. This project will provide crucial knowledge about composition and maturation of the virome during the first year of life, and its symbiotic relation with the bacterial microbiome. This longitudinal dataset will be instrumental for identification of microbiome markers of diseases and for the follow up analysis of the long-term effect of microbiota maturation later in life. Knowledge of the role of viruses in shaping the microbiota may promote future directions for manipulating the human gut microbiota in health and disease.

Keywords: virome,microbiome,microbiota,newborns,longitudinal study,gut health
BEaring Advanced Technologies for Turboprop engine Innovation (BEATTI)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France
Call: Advanced Bearings for Turboprop engine (H2020-CS2-CFP03-2016-01, 2016)
Start date: 2017-01-16
End date: 2021-08-15
Duration (months): 55.0
Total project cost (EUR): 712650.0
EU funding (EUR): 498855.0
Participants: 2
Project status: CLOSED

Turboprop engine is the key to contribute to the EU competitiveness growth as well as to tackle the important commitment of sustainable and green transport (SAGE programme). This innovation will be clearly addressed also by the bearings that are directly involved in power efficiency and reliability, highly crucial for the engine development itself. BEATTI project proposes advanced bearings (in term of material and design) with improved dynamic and thermal behaviours and resistance to harsh environment, such as corrosion, particle pollution and poor lubrication condition. To propose the best solution, it is crucial to, firstly, build up failure modes database based on field return functional analysis and testing outputs, and secondly to monitor the bearing usage condition and failure mode with advanced monitoring solution both on engine demonstrator and bearing testing rigs. By knowing real conditions it is possible to propose real solutions. In addition BEATTI will focus on the time to market for the introduction of new material: the ratio “time/resources” of new material introduction will be optimised by focusing on the best TRL level testing. The BEATTI project is thus “the development of advanced bearing solutions, enablers for the next generation of Turboprop engines that will overcome current bearing performances. An innovative approach will be applied coupling a better knowledge of usage conditions & failure modes (using advanced monitoring tools) with specific experimental demonstrations of material and design choices.”

Keywords: turboprop,turboshaft,advanced bearings,condition monitoring,mechatroncis,bearing failure mode,corrosion resistance steel
Focal volume Control Using Structured Illumination Sources (FOCUSIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-01
End date: 2023-02-28
Duration (months): 36.0
Total project cost (EUR): 245732.16
EU funding (EUR): 245732.16
Participants: 2
Project status: CLOSED

In optics, one of the important fundamental challenges is the quest for new methods to increase the spatial resolution over the natural diffraction limit of the optical system. Typically, in most of the laser-based micromachining techniques, the spatial resolution is improved by using high numerical aperture lenses in combination with short wavelengths, relying on multiphoton absorption, and working near to the modification threshold to decrease effectively the focal volume and therefore the minimum feature size. Thus, the control of the focal volume dimensions will strongly influence the limits of the system resolution, constituting a demanding and non-trivial task. Near-field optical methods presents promising approaches for this aim. The interest lies in the near-field properties; in this extremely small scale, the optical field is evanescent rather than propagating, so it is not subject of the same diffraction limit and can therefore be concentrated to smaller volumes. Considering this, the present proposal main objective will focus on the evaluation and implementation of the necessary conditions to modify and control the focal volume dimensions in an optical system combining the near-field phenomena induced with different illumination methods. The project will include the development of experiments and simulations for the understanding of the propagation of shaped beams in a particular optical system. The obtained results will be then applied for the nanoprocessing of materials with femtosecond laser pulses. This proposal emphasize in both the transfer of knowledge to the host institutions and the training of the candidate in well-stablished advanced techniques towards the development of the candidate’s career in optics. The multidisciplinary nature of this proposal will strengthen international cooperation, a key initiative of the Innovation Union. This kind of project design is in line with the European strategy for Research and Innovation.

Keywords: focal volume dimensions control,near field,structured laser illumination,bessel beams,optical,microbeads,ultrashort laser pulses