Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Missing Link of Episodic Memory Decline in Aging: The Role of Inefficient Systems Consolidation (AgeConsolidate)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Norway
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-05-01
End date: 2023-04-30
Duration (months): 72.0
Total project cost (EUR): 1999481.75
EU funding (EUR): 1999481.75
Participants: 1
Project status: SIGNED

Which brain mechanisms are responsible for the faith of the memories we make with age, whether they wither or stay, and in what form? Episodic memory function does decline with age. While this decline can have multiple causes, research has focused almost entirely on encoding and retrieval processes, largely ignoring a third critical process– consolidation. The objective of AgeConsolidate is to provide this missing link, by combining novel experimental cognitive paradigms with neuroimaging in a longitudinal large-scale attempt to directly test how age-related changes in consolidation processes in the brain impact episodic memory decline. The ambitious aims of the present proposal are two-fold: (1) Use recent advances in memory consolidation theory to achieve an elaborate model of episodic memory deficits in aging (2) Use aging as a model to uncover how structural and functional brain changes affect episodic memory consolidation in general The novelty of the project lies in the synthesis of recent methodological advances and theoretical models for episodic memory consolidation to explain age-related decline, by employing a unique combination of a range of different techniques and approaches. This is ground-breaking, in that it aims at taking our understanding of the brain processes underlying episodic memory decline in aging to a new level, while at the same time advancing our theoretical understanding of how episodic memories are consolidated in the human brain. To obtain this outcome, I will test the main hypothesis of the project: Brain processes of episodic memory consolidation are less effective in older adults, and this can account for a significant portion of the episodic memory decline in aging. This will be answered by six secondary hypotheses, with 1-3 experiments or tasks designated to address each hypothesis, focusing on functional and structural MRI, positron emission tomography data and sleep experiments to target consolidation from different angles.

Keywords: neuroimaging,magnetic resonnance imaging,aging,episodic memory,memory consolidation
Cooled Fast-Response Wall Pressure Taps for Combustion Chamber Measurements (FAST TAPS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Belgium
Call: Unsteady pressure sensor for high pressure and hot environment (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-11-05
End date: 2022-08-04
Duration (months): 45.0
Total project cost (EUR): 297566.25
EU funding (EUR): 297533.25
Participants: 1
Project status: CLOSED

FAST TAPS aims at designing, validating and put in operation 8 cooled fast-response wall pressure taps for combustion chamber measurements. The project is based upon a three steps approach, the three technical work packages of the project, with two distinct iterative design and validation loops. In the first step, the measurement devices will be designed according to the desired measurement performance (i.e. the required bandwidth), the environmental conditions (high-temperature and high-pressure flow) and the structural and mechanical constraints. The design candidates will undergo an internal experimental and numerical validation process prior to the submission to the topic leader. In the second step, prototypes will be built according to the final design candidate and tested in engine-representative conditions. The analysis of the results will either provide the final approval for the machining of the final measurement devices or highlight some modifications to be further implemented. The third step deals with the final manufacturing of the cooled fast-response wall pressure taps and their qualification tests (static and dynamic calibrations). From a scientific point of view, FAST TAPS targets the definition of a new, complete and robust design methodology for fast-response pressure probes. Such knowledge is doomed to be made available to the scientific community through the FAST TAPS dissemination activities.

Keywords: fast response,wall pressure taps,cooled,combustion chamber
Metrology Advances for Digitized ECS industry 4.0 (MADEin4)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Italy,Austria,Germany,Germany,Germany,Germany,Germany,Italy,Israel,Germany,Italy,Germany,Romania,Belgium,Hungary,Sweden,France,France,France,France,France,France,France,France,France,Netherlands,Netherlands,Netherlands,Netherlands
Call: ECSEL-2018-1-IA (H2020-ECSEL-2018-1-IA-two-stage, 2018)
Start date: 2019-04-01
End date: 2022-09-30
Duration (months): 42.0
Total project cost (EUR): 126895421.62
EU funding (EUR): 29382452.24
Participants: 50
Project status: SIGNED

The metrology domain (which could be considered as the ‘eyes and ears’ for both R&D&I and production) is a key enabler for productivity enhancements in many industries across the electronic components and system (ECS) value chain and have to be an integral part of any Cyber Physical Systems (CPS) which consist of metrology equipment, virtual metrology or Industrial internet of things (IIoT) sensors, edge and high-performance computing (HPC). The requirements from the metrology is to support ALL process steps toward the final product. However, for any given ECS technology, there is a significant trade-off between the metrology sensitivity, precision and accuracy to its productivity. MADEin4 address this deficiency by focusing on two productivity boosters which are independent from the sensitivity, precision and accuracy requirements: • Productivity booster 1: High throughput, next generation metrology and inspection tools development for the nanoelectronics industry (all nodes down to 5nm). This booster will be developed by the metrology equipment’s manufacturers and demonstrated in an industry 4.0 pilot line at imec and address the ECS equipment, materials and manufacturing major challenges (MASP Chapter 15, major challenges 1 – 3). • Productivity booster 2: CPS development which combines Machine Learning (ML) of design (EDA) and metrology data for predictive diagnostics of the process and tools performances predictive diagnostics of the process and tools performances (predictive yield and tools performance). This booster will be developed and demonstrated in an industry 4.0 pilot line at imec, for the 5nm node, by the EDA, computing and metrology partners (MASP Chapter 15, major challenge 4). The same CPS concept will be demonstrated for the ‘digital industries’ two major challenges of the nanoelectronics (all nodes down to 5nm) and automotive end user’s partners (MASP Chapter 9, major challenges 1and 3).

Keywords: metrology,inspection,holistic,artificial,intelligence,common,platform,equipment,manufacturing,process,control,cyber,physical,system,edge,statistic,multi,variants
Drug combinations for rewriting trajectories of renal pathologies in type II diabetes (DC-ren) (DC-ren)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Israel,Germany,Austria,Netherlands,Denmark
Call: Systems approaches for the discovery of combinatorial therapies for complex disorders (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 5968480.0
EU funding (EUR): 5968480.0
Participants: 8
Project status: SIGNED

Diabetic Kidney Disease (DKD) is highly prevalent in type 2 diabetes, with major impact on patients and healthcare systems. The complex disorder, further modulated by cardiovascular comorbidities, presents as an accumulation of risk factors, which we treat with drug combinations. While the overall benefit of this approach is evident on a cohort level, individual patients show remarkable heterogeneity in drug response, and lack of guidance on personalized medication results in suboptimal control of the disorder. For resolving variability, we propose a new concept for personalization of drug combinations beyond the cohort-centric perspective. We improve patient stratification based on equivalence relations of clinical presentation, disease pathophysiology and drug combinations. The approach is derived from dynamical systems theory, aimed at reducing probabilistic assignment of patient-specific disease evolution and matching drug combinations. The availability of a large European repository holding DKD patients in routine care with diverse drug combinations, complemented by high-throughput screening for improving patient phenotyping, and molecular network modelling of pathology, embedded risk factor combinations and consequence of drug effect allows a systems representation of patient groups. Integrating clinical presentation and molecular architecture in a novel computational framework will establish a decision support software prototype. We will validate this tool for predicting optimized personalized drug combinations in a study using given clinical trial repositories. Demonstration will expand to other available drugs, which in combination with approved drugs promise benefit for groups of DKD patients. With a clear route toward uptake in the clinical setting, and generalization capacity of our approach to other complex disorders we foster next steps in personalization, anticipate major patient benefit, and see novel translation and business opportunities.

Keywords: diabetes associated kidney disease,drug combination therapy,pathophysiology guided precision medicine
Host-virus chemical arms race during algal bloom in the ocean at a single cell resolution (Virocellsphere)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-11-01
End date: 2021-10-31
Duration (months): 60.0
Total project cost (EUR): 2749901.0
EU funding (EUR): 2749901.0
Participants: 1
Project status: CLOSED

Phytoplankton blooms are ephemeral events of exceptionally high primary productivity that regulate the flux of carbon across marine food webs. The cosmopolitan coccolithophore Emiliania huxleyi (Haptophyta) is a unicellular eukaryotic alga responsible for the largest oceanic algal blooms covering thousands of square kilometers. These annual blooms are frequently terminated by a specific large dsDNA E. huxleyi virus (EhV). Despite the huge ecological importance of host-virus interactions, the ability to assess their ecological impact is limited to current approaches, which focus mainly on quantification of viral abundance and diversity. On the molecular basis, a major challenge in the current understanding of host-virus interactions in the marine environment is the ability to decode the wealth of “omics” data and translate it into cellular mechanisms that mediate host susceptibility and resistance to viral infection. In the current proposal we intend to provide novel functional insights into molecular mechanisms that regulate host-virus interactions at the single-cell level by unravelling phenotypic heterogeneity within infected populations. By using physiological markers and single-cell transcriptomics, we propose to discern between host subpopulations and define their different “metabolic states”, in order to map them into different modes of susceptibility and resistance. By using advanced metabolomic approaches, we also aim to define the infochemical microenvironment generated during viral infection and examine how it can shape host phenotypic plasticity. Mapping the transcriptomic and metabolic footprints of viral infection will provide a meaningful tool to assess the dynamics of active viral infection during natural E. huxleyi blooms. Our novel approaches will pave the way for unprecedented quantification of the “viral shunt” that drives nutrient fluxes in marine food webs, from a single-cell level to a population and eventually ecosystem levels.

Keywords: algal blooms,phytoplankton,coccolithophores,marine viruses,phycodnaviridae,transcriptomics,single cell analysis,infochemicals,metabolomics,sphingolipids,cell signaling,stress response
“EPIgenetic impacts on early-stage SPECiation and adaptive radiation” (EpiSpec)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Phenotypic plasticity plays a key role at the onset of the speciation process, facilitating diversification though the induction of novel phenotypes in response to distinct environments. Via genetic accommodation and genetic assimilation, this influence may extend throughout the speciation process and beyond, into subsequent speciation events. While the epigenetic regulation of gene expression that mediates phenotypic plasticity has been extensively studied in lab-based model organisms, very little is known about epigenetic variation in natural populations. This project will be the first epigenetic study explicitly focused on the speciation process. Using cutting-edge techniques, the applicant will characterize DNA methylation variation within and among the sympatric species of a recently discovered endemic cichlid fish radiation in Lake Massoko, Tanzania. Specifically the applicant will test: if 1) newly formed species differ in the distributions of epigenetic marks across the genome, 2) genomic variants linked to phenotypic divergence among species are in genomic regions unusually high in DNA methylation, as expected under a hypothesis of epigenetic differences preceding fixed nucleotide differences during adaptive divergence, 3) genomic regions diverging in patterns of methylation among incipient species are also exhibiting high levels of methylation in populations of Astatotilapia calliptera, the ancestral, colonizing species. The results of this pioneering project will provide the first empirical evidence of the importance of epigenetic variation during the emergence of new species.
Support for the Intergovernmental Panel on Climate Change to facilitate the preparation of its Sixth Assessment Report (IPCCAR6)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Coordination and support actions
Countries involved: Switzerland
Call: IPCC secretariat (H2020-IBA-SC5-IPCC-2017, 2017)
Start date: 2017-10-01
End date: 2022-03-31
Duration (months): 54.0
Total project cost (EUR): 1100000.0
EU funding (EUR): 1100000.0
Participants: 1
Project status: CLOSED

The Intergovernmental Panel on Climate Change (IPCC) is the key global climate science-policy interface, underpinning international climate change policy-making an dis the leading global body responsible for the scientific assessment of climate change. In preparation of the IPCC Sixth Assessment Report (AR6), support will be provided to increase the participation of experts from developing countries and economies in transition, should their governments not be in a position to provide appropriate funding, consistent with IPCC standard operating procedures, to the IPCC process and enhance visibility of the IPCC products worldwide.

Keywords: climate change,physical science,impacts,vulnerability,adaptation,mitigation,oceans,cryosphere,global warming
A Programming Platform for Reactive Data-intensive Applications (REScala)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Ubiquitous connectivity of digital and physical worlds enabled by the convergence of edge (IoT, mobile), in-network and cloud computing plus algorithmic advances in artificial intelligence (AI) promise breakthroughs in next-generation Distributed Data-driven Reactive Applications (DRAs), which promise to radically innovate the economy and induce society-scale impact on production, mobility, energy, health, etc. But, such next-generation DRAs are not only expensive and difficult to develop, deploy, and maintain; it is also extremely hard to reason about and to ensure their quality. The goal of this Proof of Concept proposal is to build a business strategy for the implementation and provisioning of enterprise-level programming and methodological support for DRAs. The comprehensive REScala package provides necessary programming tools to support the cost-effective and quality-ensuring implementation of next-generation DRAs across application domains (mobility, energy, health, environment, etc.), involving and combining intelligent user interfaces and computations running on distributed computing platforms with decentralised state. Summarizing, REScala holds great promise to be an important enabler of next-generation DRAs. We expect the innovation potential of this PoC project to be comparable to that unleashed by the invention of smartphone platforms, which unified a myriad of separated silo technologies that emerged on top of mobile communication technology. With REScala’s distributed and decentralised computing model, developers can plug-in their DRAs similar to installing new apps.

Keywords: reactive data intensive applications,programming platform
Single Molecule Imaging-based design of HIV-1 vaccines (FUSION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-04-01
End date: 2026-03-31
Duration (months): 72.0
Total project cost (EUR): 2280390.0
EU funding (EUR): 2280390.0
Participants: 1
Project status: SIGNED

The HIV-1 vaccine research has re-emerged in the last few years due to the identification of antibodies that neutralize most HIV-1 circulating strains. A deeper understanding of the mechanistic mode of target recognition for these antibodies represents a big hope in the field. This project aims at understanding and characterizing polyclonal antibody responses to aid rational vaccine design via radically new technologies on light microscopy. The molecular mechanism of time-resolved HIV-1 fusion will be visualized and quantified on the surface of living cells by combining real-time single virus tracking, fluorescence fluctuation spectroscopy and 3D single molecule localization microscopy (SMLM) imaging. The implementation of a new technology that allows three-dimensional nanometre localization of single particles will allow us to multiplex single molecule experiments with functional readouts for single-virus HIV-1 fusion simultaneously. Here, I will systematically establish the mechanism of action of different families of neutralizing antibodies and how they disrupt the three-step HIV fusion reaction, conserved among different HIV tropism, recently discovered by our group. I will unveil the molecular insights on the precise Env-induced, time-resolved stoichiometry of CD4 and co-receptors (CCR5 or CXCR4) in the presence and absence of different combinations of bNAbs and study their impact on HIV transmission. FUSION will open new avenues to design putative drugs that target host-specific receptor and co-receptor oligomeric states to block HIV-1 fusion. This project systematically applies cutting-edge time-resolved imaging approaches as a gold standard to ascertain how different combinations of bNAbs perturb the HIV fusion mechanism in CD4+ T cells and macrophages. I will establish a world-class laboratory in HIV-1 and single molecule microscopy. I will decipher several key virus–host cell interactions at molecular level and contribute to rational vaccine and drug desig

Keywords: single molecule fluorescence,number and brightness,single virus tracking,super resolution light microscopy,hiv 1 fusion,membrane fusion mechanism,broadly neutralizing antibodies,live cell imaging