Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Petro-Ambiguity: Oil, Environment and National Identity in the Bruneian Imaginary (Petro-Ambiguity)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 226751.04
EU funding (EUR): 226751.04
Participants: 1
Project status: CLOSED

Petro-Ambiguity: Oil, Environment and National Identity in the Bruneian Imaginary will uncover diverse new narratives of the Anthropocene beyond the Global North. In close collaboration with my supervisor, Prof. Sissel Furuseth, head of the Critical Petroaesthetics research group (CP) into which I will be integrated, I will investigate the stories of oil in Brunei, whose oil-based economy has allowed for the preservation of its rainforest and a generous citizen welfare system. Its story is distinct to those that currently dominate the energy humanities, characterized by economic instability, environmental injustice and political violence. Through vital training and interactions with my supervisor and CP researchers, I will develop a synthesized approach informed by material ecocriticism, scale reading and intersectionality to analyse contemporary cultural forms in the Bruneian petroculture. I will introduce petro-ambiguity as a ground-breaking concept that resists universalizing oil encounters by articulating the intra-actions between individual, socio-cultural, national and global perceptions of oil. By moving beyond the Global North, this project addresses inequities within local and global energy-climate discourses, an urgent and crucial undertaking for a just energy transition for all. This project will engage in high-impact dissemination activities to enhance understanding of sociocultural factors behind climate (in)action. Petro-Ambiguity will be bolstered by feedback from renowned energy-climate experts on my advisory board, Prof. Stephanie LeMenager (University of Oregon), Prof. Adeline Johns-Putra (Xi'an Jiaotong-Liverpool University) and Prof. Indra Øverland (Norwegian Institute of International Affairs). The Oslo School of Environmental Humanities based at the University of Oslo will create the perfect environment as host for cutting-edge research groups on energy and environment to which Petro-Ambiguity will add an essential non-European angle.

Keywords: petroculture ecocriticism energy humanities environmental humanities climate and literature
A game changer for the treatment of osteoarthritis: a cost effective combined advanced therapy to treat knee osteoarthritis (SINPAIN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Spain,France,Germany,Portugal,Italy,Switzerland,United Kingdom,Iceland,United States
Call: Next generation advanced therapies to treat highly prevalent and high burden diseases with unmet medical needs (HORIZON-HLTH-2021-TOOL-06, 2021)
Start date: 2022-05-01
End date: 2026-10-31
Duration (months): 54.0
Total project cost (EUR): 5387558.0
EU funding (EUR): 5387557.0
Participants: 13
Project status: SIGNED

According to the WHO Osteoarthritis (OA) is one major course of years lived with disability in the elderly and considered a high burden disease, which makes it a research priority in Europe. There is no cure for OA and SoA treatments need to be reconsidered. Current pharmacological interventions consist of analgesic, anti-inflammatory drugs as well as intraarticular steroids and hyaluronic acid (IA-HA) with moderate efficacy and associated long-term side effects. New medications are thus needed both to alleviate pain and slow down disease progression. Taking advantage of the explosion of RNA technologies in the last years, SINPAIN aims to develop a pipeline of siRNA-based therapy built on the combination of current technologies (dyanmic IA-HA and nanocarriers) that will be designed step-by-step in order to reach a successful management of inflammation and innervation therapy for the treatment of early (grade 0-1) and later stages (grade 3-4) of knee osteoarthritis (OA). To do so, a nanoformulation composed of functional IA-HA that can be loaded with vectors, for the delivery of siRNA targeting IL1? and NGF, and nanocarriers will be developed. In parallel, large effort will focus on understanding the pathological mechanisms of OA. To validate efficacy in relevant potency assays, 3D coculture models will be developed with human cells and tested in unique bioreactors mimicking joint environment and biomechanics. With the identified cell targets, IA-HA will be modified with immunomodulator peptide which will activate the adaptive immune response, responsible for OA regeneration. The 4 pipeline products of SINPAIN will be validated in vivo in a relevant OA model with SoA techniques that will demonstrate the reduced inflammation and pain, as well as the cartilage regeneration for the last product. Taking advantage of all the data obtained during the project, a decision-making tool based on machine learning will be validated to offer patients a personalized therapy.

Keywords: osteoarthritis,crosstalk cellular interaction,rna based therapy,inflammmation,pain,subchondral bone,regeneration,adaptive immune reaction,decision making tool,machine learning
BlueMissionMed - Supporting the Mediterranean Sea Basin for the implementation of the EU Mission Restore Our Ocean and Waters (BlueMissionMed)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Coordination and support actions
Countries involved: Italy,France,Greece,Spain,Türkiye,Tunisia,Malta
Call: Mediterranean sea basin lighthouse – coordination activities (HORIZON-MISS-2021-OCEAN-03, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 3000097.51
EU funding (EUR): 3000097.25
Participants: 17
Project status: SIGNED

The Mission Restore our Oceans and Waters by 2030 provides a holistic and coherent framework for developing a systemic approach to the depollution and regeneration of the basin hydrosphere, which is a striking need in the Mediterranean Sea (MED). In the BlueMissionMed proposal, a multi-actor, trans-sectorial and multidisciplinary consortium, consisting of 6 R&I public institutions, 6 NGOs, 2 industrial associations, 1 private enterprise and 1 SME from 5 MS and 2 AC of the MED, proposes to set up, structure and empower a MED Lighthouse supporting the development and deployment of transformative innovative technological, social, business and governance solutions for ensuring a 30-50% reduction of pollution of the basin hydrosphere by 2030. It will be an interactive multi-actors digital platform able to offer to all MED Countries/Regions and stakeholders to access the necessary knowledge and tools. It will build on, connect and structure existing initiatives and activities, including the 9 Pilot BLUEMED on plastics free healthy MED and will exploit the R&I and policy knowledge generated by the funded projects/initiatives on the MED decontamination and restoration, ultimately promoting basin-wide cooperation, commitment and deployment of solutions addressing the Mission objectives. The Lighthouse will also ensure i) coherence, alignment and monitoring of EU, national and local policies, initiatives and actions ongoing the MED basin; ii) an effective provision of technical services, governance and business models to support and guarantee a sustainable socio-economic development of the basin; iii) a well-functioning basin scale innovation ecosystem attractive towards investors and businesses, iv) the required engagement of the society at large, thanks to a robust awareness raising and citizen science approach in its implementation in the sea basin and beyond, and, thus, v) the effective deployment of Mission Implementation Charter and piloting of the Mission objectives for the MED by 2025.
Methyltransferase inhibitors for treatment of COVID19 (MeTIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-06-01
End date: 2023-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Our IP secured drug DZNep is effective in treating SARS-CoV-2 infections in preclinical disease models and uniquely suppresses virus growth, triggers the innate immunity and facilitates tissue regeneration. The ERC-PoC will enable the transition from preclinical to clinical research.
Preliminary demonstration and valorization of therapeutic rewiring of severed spinal cord (SPINETRACER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-06-01
End date: 2026-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: SIGNED

SPINETRACER aims to restore the lost functions of patients suffering from spinal cord injury (SCI) by providing a conductive scaffolding implant for the growth of severed nerve fibres. Not thicker than an inch, the spinal cord has no way to heal when severed. Our creative idea is to provide an artificial support that can mimic and stimulate neuronal electrical connections. This scaffold can bridge the gap created by SCI and enable the return of motor and sensitive function. We have previously demonstrated that carbon nanotube (CNT) implants in rats lead to the recovery of motor activity in very short times after an otherwise paralyzing lesion to the spinal cord. For the first time it was possible to observe the regrowth of nerve fibres leading to restoration of motor function (published on PNAS 2020, 117, 25212). In this innovative approach, it was also possible to show that the scaffolds, when inserted in the lesion, became filled with newly sprouted nerve fibres. The long-term objective of SPINETRACER is to take to clinical practice our novel solution for the restoration of motor functions in patients suffering from SCI. To this end, we will combine our proprietary technology, based on CNT-containing hydrogels, and our recently developed neuroanatomical magnetic resonance imaging tracer based on carbon nanodots, for precise in vivo imaging of the progression of the spinal cord regeneration, to complete our preclinical studies. We expect to take further steps into the demonstration of technical and economic viability of this initiative by improving implant design and production processes, restoring motor function in small mammals and designing an appealing business model to exploit the asset. By the end of this Proof of Concept we expect to have acquired all the necessary data to move into the next stage of the road towards clinical implementation of the solution.
Morphogenesis meets Cell Fate: Dissecting how Mechanical Forces coordinate Development (MechanoFate)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

During embryonic development, an unspecialized cell mass is transformed into complex tissues and organs through collective movements and cell interactions. The acquisition of such structural and functional diversity is powered by two main processes: morphogenesis, which sculpts cells into tissues and organs, and cell fate acquisition, which assigns specific identities to cells. Despite extensive research, the intricate coordination between these two processes remains elusive. Mechanical forces determine the shape and structure of tissues, and their impact on cell fate has been recently uncovered, emphasizing the significance of mechanics in regulating both morphogenesis and cell fate. However, understanding the relationship between these two processes is complex, as it requires the integration of cell shape, cell behavior, mechanics, and gene expression across the tissue over time. In this project, we will apply cutting-edge biophysical and data science methods to the mucociliary epithelium of Xenopus embryos to dissect the role of mechanics in both morphogenesis and cell fate acquisition in vivo. We will first determine how cells undergoing fate acquisition trigger local tissue rearrangements that lead to global morphogenetic movements. Next, we will investigate the impact of tissue mechanics on cell fate and transitions. Finally, we will combine cell behaviors, gene expression, and mechanics into a model to predict cell fate. By exploring the ways cells respond to and modify their mechanical surroundings and the circumstances in which external forces determine cell fate, we will uncover the basic principles of complex tissue formation. This research will give us a comprehensive understanding of how individual cells, as mechanical elements, interact to form a tissue structure that is more than just the sum of its parts. The findings will have a significant impact on other tissues, particularly the human airways, and advance our knowledge of embryonic development.

Keywords: biophysics,tissue mechanics,mechanics of cell fate,multiomics,scrnaseq,mechanical forces,xenopus,mucociliary epithelium,epithelial mechanics,embryonic development,mechanical probing,machine learning,quantitative imaging,live imaging,cellular behavior,tissue stretching,tissue rheology
Accurate quantification of neurologic disease over time (CHRONOS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Norway
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-06-01
End date: 2026-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

A research discovery has little relevance if it never makes an impact on its target users. A key challenge for radiology is that very few diagnostic innovations end up changing clinical practice. Most clinical decision-making processes follow the same hypothesis-driven approach where the association between a biomarker and disease status are assessed by trial-and-error. By forcing the patients’ data into traditional paradigms, we are inherently making poor use of the available information. Moreover, a new drug or change in treatment have little impact if the intervention is initiated at a late stage. For a patient with short life expectancy, this scenario is unacceptable. A new diagnostic paradigm is needed to catch disease status before it becomes symptomatic. Based on the work of an ERC Starting Grant, we introduce a new paradigm for clinical neuroimaging, coined synthetic biomaps, where artificial intelligence brings to life hidden information stored in diagnostic images. As an intelligent decision-support system, CHRONOS is a fully developed software prototype that enhance classical image analyses with synthetic biomaps to produce smarter and better diagnoses of disease. We showcase how a growing brain tumor change the entire architecture of the brain more than six months before these changes are observed by traditional means. This innovative step will allow the treating physician to make the correct clinical decisions at an unprecedented and early timepoint. We have integrated our invention in a hospital-approved digital framework that allows our clinical experts to validate the technology and demonstrate its clinical value. Our initial market analysis and a favorable search report show that a substantial commercial value can be realized by positioning CHRONOS at the center of a wider strategy of a new company to introduce sibling AI-imaging solutions. Τhis project aims to set the stage for an investor ready spinout company based on the CHRONOS technology.
IMaging PROstate cancer using ViscoElastic biomarkers and a novel transurethral viscoelastic elastography procedure (IMPROVE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,United Kingdom
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: SIGNED

IMPROVE aims to demonstrate the potentiality of Transurethral Shear Wave Viscoelastic Elastography (TUSWAVE) for ‘improving’ the diagnosis of Prostate Cancer (PCa) by identifying it through a new set of biomarkers based on the fractional viscoelastic properties of the prostate. TUSWAVE is a novel concept based on the transmission and reception of shear waves in the prostate through the urethra. Most prostatic tumours are stiffer than normal surrounding tissue, which perturbs the propagation of shear waves. The perturbed waves carry information about the location and changes in the viscoelastic properties of the tumours. IMPROVE aims to further study the correlation between diagnosis features of prostate cancer, such as grade, stage and vascularisation, with shear fractional viscoelastic properties of the prostate, i.e. the shear modulus, the shear viscosity and the fractional-order parameter. To achieve IMPROVE’s goal three main work packages are proposed. First, the development of a 3D anatomically realistic wave propagation model validated in ex vivo human prostate; second, the characterisation of the fractional viscoelastic properties of prostatic tissue under different pathological conditions using Shear Wave Elastography and validated against independent techniques; and finally, the development of a preliminary Artificial Intelligence-based image reconstruction method for TUSWAVE. A large database of prostate cancer clinical scenarios will be generated using the data from the characterisation study and the 3D wave propagation model. This database will be used to train and test the image reconstruction method. Prostate-like phantoms will be used to test the performance of the image reconstruction method. IMPROVE will take TUSWAVE towards a pre-clinical studies stage. IMPROVE is aligned with the mission area 'cancer' set on Horizon Europe.

Keywords: elastography prostate cancer viscoelasticity biomarker medical imaging reconstruction
Research Infrastructure Services for Renewable Energy (RISEnergy)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Services and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Austria,France,Spain,Italy,Cyprus,Portugal,Belgium,Netherlands,Ireland,Greece,Bulgaria,Denmark,United Kingdom,Norway,Türkiye,Czechia,Sweden,Romania
Call: Research infrastructure services to enable R&I addressing main challenges and EU priorities (HORIZON-INFRA-2023-SERV-01, 2023)
Start date: 2024-03-01
End date: 2028-08-31
Duration (months): 54.0
Total project cost (EUR): 14499997.6
EU funding (EUR): 14499997.59
Participants: 55
Project status: SIGNED

The European Green Deal aims to transform the EU into a modern, resource-efficient and competitive economy with zero net greenhouse gas emissions by 2050. To achieve more efficient, competitive and cost-effective energy systems and devices, RISEnergy fosters a European ecosystem of industry, research organizations and funding agencies aimed at developing novel energy technologies and concepts. RISEnergy brings together a consortium of 69 beneficiaries from 23 countries: ERIC institutions, technology institutes, universities and industrial partners, to jointly improve the economic performance of technologies. Members of the European Energy Research Alliance are establishing the core European ecosystem. The main objectives of RISEnergy are: 1.) enable research and innovation to increase energy efficiency and reduce the cost of energy technologies to foster wider use of renewables into energy systems through proactive innovation management having single entry point with tailor-made access roads for academics, industry, and SMEs, and advising RI providers, all acces Users, and policy makers on LCA, ICT development and networking issues; 2.) provide efficient transnational access (TNA) to facilities to support renewable energy technologies and systems: Provide more than 2,500 days of access to major European and international world-leading analytical facilities; 3.) reach out to all stakeholders performing research along the value chain, from materials and technology development to applications in the eight most relevant fields of PV, CSP/STE , hydrogen, biofuels, offshore wind, ocean energy, integrated grids, and energy storage, research infrastructure providers and policy makers; 4.) provide comprehensive services of unprecedented quality: new cross-RI services, a single entry point, tailor-made access roads for academia industry, and SMEs with a particular focus on scientists from research fields in which the use of research infrastructures is not yet established.

Keywords: renewable energy technologies,research infrastructures,ecosystem,energy efficiency,cost reduction,innovation chain,materials to devices,ict enabling,meta data,training,evidence based policy