Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
VIA-TARIQ: Analysing the long-term change and persistency of the Roman road system in the Levant (VIA-TARIQ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

The ‘VIA-TARIQ’ is an interdisciplinary project that aims to explore key topic among the archaeologists and historians of the Near East: what is the level of persistency/discontinuity of the Roman road system in the longue durée and what influences it had on the social and economic developments in the Medieval and modern period. The project will approach these issues through analysis of large aggregated archaeological datasets and advanced spatial modelling methods, enabled through training in these methods at the host institution. The project will significantly add to our understanding of the centuries-long change and development of the road and transport networks in the Levant. It will illuminate the long-term effects of the Roman road infrastructure on the economic developments in the Medieval and Ottoman periods. The training and research offered by the project will position the applicant as an expert in archaeological computational modelling for the study of the past and will enable him to influence paradigms and inform debates in the history and archaeology of the Near East.

Keywords: historical roads,persistence,transport networks,spatial analysis,gis
BioBone: Bioactive Hydrogel-based Implants to Induce Bone Regeneration (BioBone)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel,Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-03-01
End date: 2025-08-31
Duration (months): 18.0
Total project cost (EUR): 162857.14
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

Osteosarcoma and Ewing sarcoma are the most common types of cancer in patients younger than 30 years. The gold standard treatment is bone tumor resection followed by reconstruction of the tissue, thereby allowing the salvage of the limb. Titanium and its alloys are mostly used in such orthopedic surgeries due to their biocompatibility and excellent mechanical properties. A novel, cutting-edge technology of patient-specific implants, 3-dimensional (3D) printed porous titanium implants, was recently introduced to clinical use. Yet, even several years after surgery, the resected section is not fully reconstructed, leading to further medical complications often requiring re-operations. A promising solution is the combination of titanium porous implants with bioactive scaffolds to support bone regeneration following tumor resection. Here, we aim to fabricate a 3D-printed porous titanium implant incorporated with patent-protected bioactive materials we have developed in the scope of the PersonalBone ERC-StG project to provide an optimal microenvironment for stimulating bone regeneration following bone tumor resection. For this purpose, we will optimize the formulation as well as the method of incorporation into 3D-printed titanium implants. The incorporated implants will be tested for biocompatibility and osteointegration in critical-size bone defect models in vivo. As we recently demonstrated for the novel materials, we will examine several success criteria, which will be refined according to input from orthopedic oncology surgeons who routinely perform tumor resections. This novel technology is envisioned to significantly advance the current treatments offered following bone resection, thereby considerably reducing the risk of further complications and offering a major improvement in the quality of life of patients recovering from bone cancer.
Wind Hybrid Evolution for Low-Carbon Solutions (WHEEL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Spain,Netherlands,Germany,Belgium,Switzerland,United Kingdom,Norway
Call: Innovation on floating wind energy deployment optimized for deep waters and different sea basins (Mediterranean Sea, Black Sea, Baltic Sea, North-east Atlantic Ocean) (HORIZON-CL5-2021-D3-03, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 25358675.34
EU funding (EUR): 16663950.5
Participants: 17
Project status: SIGNED

The overall objective of the WHEEL project is to fully demonstrate and bring to a precommercial Technology Readiness Level (TRL) a revolutionary floating wind technology excellently suited for deep water locations, effective industrialization strategies, breakthrough cost reduction and minimized carbon footprint. This shall enable a radical step forward for LCoE reduction, whilst also addressing scalability, harbour infrastructure suitability and availability, and the sustainability & circularity of floating offshore wind. Development and demonstration needed to reach the pursued TRL will be achieved through the design, installation, certification and testing of a fully operative 6MW Pilot unit, which will showcase and demonstrate the breakthrough advantages that the WHEEL technology can deliver to the floating wind industry. It will be installed in a deep-water location in the PLOCAN testing area (Canary Islands, Spain), where it shall be thoroughly monitored along a period sufficient to underpin the commercialization and bankability of the technology. The WHEEL project pulls together a Consortium of renowned European companies and research institutions with extensive experience and a spearhead position in the renewables and marine industry. This multidisciplinary team joins forces to complete the full demonstration of such a disruptive technology by integrating complementary expertise fields and capabilities which effectively cover all key areas of floating wind systems in pursuit of the ambitious objectives of the project.

Keywords: floating,wind energy,atlantic,circular economy,sustainability
Soft function Simulation and Evaluation of Real and Virtual Emissions for Non-GLobal observables (SoftSERVE-NGL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-04-15
End date: 2026-04-14
Duration (months): 24.0
Total project cost (EUR): 183600.96
EU funding (EUR): 183600.96
Participants: 1
Project status: SIGNED

To facilitate the resummation of non-global logarithms and thereby enhancing theoretical predictions for collider phenomenology, I propose a project to calculate NNLO (order alpha_s^2) soft functions for non-global observables in Soft-Collinear Effective Theory (SCET), using semi-numerical methods. The proposed framework consists of two steps: First, the universal structure of soft and collinear divergences in Quantum Chromodynamics (QCD) is analysed to isolate singularities in an observable-independent fashion, after which the remaining phase space integrations are performed numerically. The objectives of the project are the release of a public software package for use by phenomenologists, and the use of the universal divergence structure to relate different classes of observables and shed light on properties of QCD factorisation (with the equivalence of virtuality and rapidity anomalous dimensions as a concrete example). The project is structured into six work packages: WP1: application to SCET-1 ("energy-type") observables without clustering effects, WP2: SCET-1 with clustering effects, WP3: SCET-2 ("transverse momentum-type") observables, WP4: development of a software package, and WP5: Exploitation, WP6: communication, dissemination, and training. The project is inspired by previous efforts directed at the much simpler "global" observables. As non-global observables are less investigated yet ubiquitous in collider physics (e.g. jet observables), and resummation calculations for them are only regularly performed in the large Nc limit and at low logarithmic accuracy, a framework to calculate soft functions for wide swathes of observables can be of tremendous service to the community. The systematic separation of observable-dependent features from universal structures can also help shed light on fundamental properties of QCD factorisation, via e.g. an observable-independent analysis of Glauber modes and their impact on factorisation.

Keywords: resummation,effective field theories,soft collinear effective theory,quantum chromodynamics,collider phenomenology,semi numerical calculations
Maritime Methanol: Adaptable, Renewable and Environmentally-friendly (M2ARE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Germany,Greece,Italy,France,Netherlands
Call: Demonstration of synthetic renewable fuel for aviation and/or shipping (HORIZON-CL5-2023-D3-01, 2023)
Start date: 2023-12-01
End date: 2027-05-31
Duration (months): 42.0
Total project cost (EUR): 9347605.25
EU funding (EUR): 7559885.68
Participants: 9
Project status: SIGNED

The M²ARE project develops and demonstrates a novel process for “Maritime Methanol”, a new grade of low-cost green methanol based on biogenic CO2 and renewable H2, to support the needs of the global shipping sector to reduce their CO2 emission. The highlights of the M²ARE project: Assessment and qualification of bio-CO2 from different sources (biogas, bioethanol, pulp & paper, combustion, …) for its feasibility in the methanol synthesis, thus increasing the feedstock base for Maritime Methanol. An improved methanol process using a new reactor system based on process intensification and a simplified methanol purification will be demonstrated. The new process is uniquely suited to convert bio-CO2 compositions with fluctuating H2 supply to flexible grades of Maritime Methanol which will be further optimised in its composition and validated through a series of engine tests. A digital model of the whole value chain from CO2/H2 to the maritime fuel will be developed to de-risk the technology and boost its scale-up by assessing and optimizing different geographical scenarios as basis for the deployment roadmap. M²ARE is committed to deliver by mid 2027 a European “Maritime Methanol” process (at TRL 7) providing >80% CO2 emission reduction compared to fossil maritime fuels and >10% TCO savings compared to state-of-the art green methanol technologies. M²ARE consists of a powerful and capable consortium with diverse expertises around the value chain: Air Liquide as world-leader in methanol technology, MAN as world leader for methanol-fueled maritime engines and Maersk as the world’s largest shipping company will provide industrial perspectives, while academic partners from Greece (CERTH), Italy (SSSA Pisa), France (LRPG) and The Netherlands (TU Delft) will contribute with unrivaled scientific expertise in catalyst testing, digital tools, reactor simulation and Life Cycle Assessment. Finally, ETA Florence will guarantee top-level dissemination of the project results.

Keywords: methanol,maritime fuel,renewable,shipping,
INNOVATIVE DELTA QUALIFICATION APPROACH FOR ELECTRIC PROPULSION SYSTEMS (INVICTUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: France,Germany,Italy,Poland
Call: Space technologies for European non-dependence and competitiveness (HORIZON-CL4-2023-SPACE-01, 2023)
Start date: 2023-12-01
End date: 2026-07-31
Duration (months): 32.0
Total project cost (EUR): 4273418.93
EU funding (EUR): 2991393.25
Participants: 6
Project status: SIGNED

The current medium power PPS®5000 thruster unit which equips several satellites uses xenon as its propellant. However due to a sharp rise in costs and an emerging shortage of xenon, significant impacts on the economics of certain future mission profiles such as those planned for the replacement of current geostationary (GEO) telecommunication satellites are expected. It is thus necessary to seek alternative more abundant and cheaper propellant alternatives such as krypton. However, today there is no European thruster available on the market in the range 2.5 to 5 kW qualified to be used with krypton. The replacement of xenon by krypton would normally require a full qualification comprising many hours years of ground testing to be performed prior to obtain the ‘ready for flight’ status as required by the current ECSS standards. This full qualification serves to provide a high level of confidence in the thrusters operational abilities but it is a timely and costly process. INVICTUS proposes to implement a delta-qualification approach to extend the qualification status of an established electrical propulsion system. The successful acceptance of this approach by the satellite integrator and operators, will be an important stepping stone to help future programs towards a clear evolution in the ECSS standards. It will also be possible to generalize this approach to changes not only limited to propellant or cathode emitter material, but will help address other future potential modifications driven by innovation such as changes in discharge chamber wall material or electro-magnet coils settings. By the end of project, the PPS ®5000 will be ready for flight (TRL8) using krypton, a worldwide first-of-a-kind based on two delta qualifications exercises (xenon to krypton with the necessary adaptations to the fluidic regulator and PPU NG2, and a change from an Asian to an EU supplier for the Cathode emitter) allowing the deployment of these thruster units by 2026.

Keywords: electric propulsion system,ecss,krypton,cathode emitter,communication satellites,endurance tests,coupling tests,ppu,failure analysis,system modelling,delta qualification,methodology
Science, technology and research for ethical engagement translated in society (S.T.R.E.E.T.S.)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Italy
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-04-21
End date: 2026-04-20
Duration (months): 24.0
Total project cost (EUR): 486607.14
EU funding (EUR): 456875.0
Participants: 13
Project status: SIGNED

The present version of the project S.T.R.E.E.T.S. (Science, Technology, and Research for Ethical Engagement Translated into Society) 2024-2025 marks a significant shift from the previous proposal: the most evident change is the shift of our focus from the streets to the squares as the focal point for the initiatives. This transition, defined as "S.T.R.E.E.T.S. to (the) square", also represents an elevation to the next level of engagement and an enhancement of the results of the previous project. The objectives remain consistent, emphasizing in all the initiatives the promotion of scientific understanding, opposing to misinformation, engaging the public, fostering public participation, advocacy for ethical research, and promoting innovation and social development. The project will continue to engage the entire Campania region and southern Lazio, potentially encompassing approximately 10% of Italy's population. The collaboration among all the prominent public universities of the Campania region, the network of more than 26 CNR Institutes, private companies, and various new third parties is confirmed. This result gives an idea of the positive impact of the first two years of implementation. Furthermore, the project addresses key themes on Europe's developmental agenda notably through the EU Missions. A specific attention is dedicated to the relationship with schools: researchers will engage with teachers, educators and pupils on challenges related, for instance, to climate change, sustainable development, health. Schools' initiative will also promote gender balance, diversity and inclusiveness in science in terms of planned activities and researchers involved. In this dynamic, the transition to squares as a meeting point represents a dynamic response to the evolving needs of society, ensuring that the project remains at the forefront of fostering a symbiotic relationship between science, technology, research, and society for the common good.

Keywords: public engagement citizen science science for sustainability technology and people research for the future participatory science outreach,collaboration,and dissemination
Photocatalyzed enantiodivergent synthesis of homoallylic and carboxylic acids featuring heterodiaryl quaternary carbon stereocenters (PEACE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: CLOSED

The synthesis of heterodiaryl-based quaternary stereocenters is a very challenging task in organic synthesis, especially in the creation of highly functional scaffolds. Tetrahedral, congested carbons centers bearing two different aryl moieties have great importance for structure−activity relationship (SAR) studies in pharmaceutical discovery programs. Their presence in biological active natural products makes them fundamental for the future development of new bioactive molecules. Up to now, their synthesis requires unsustainable methodologies that involve high cost, unfavourable step-economy and a negative waste profile features and need highly reactive compounds that only permit low functional groups tolerance. Moreover, the enantioselective synthesis of both product enantiomer requires the use of both catalyst enantiomers raising the cost of the process. Therefore, it is fundamental to develop a simple, scalable and environmentally friendly approach for the enantioselective synthesis of compounds comprising heterodiaryl-quaternary stereocenters and functionalized derivatives. The PEACE project aims to develop a novel photocatalyzed, enantiodivergent synthesis process leading to such heterodiarylated all-carbon stereocenters. The designed dual catalytic cycle of the PEACE project merges Pd and photoredox catalysis to promote the enantioselective construction of new sp3-sp2 carbon-carbon bonds resulting into products featuring a quaternary carbon stereocenter. The enantiodivergent strategy is based on a judicious choice of structurally modular reaction partners with switchable aryl groups. The combination of VCCs (vinyl,aryl-substituted cyclic carbonates) and a new aryl radical precursor offers an innovative enantiodivergent reaction pathway leading to challenging quaternary stereocenters creating impetus in the area of organic synthetic chemistry, and revolutionizing similar synthetic designs in the pharmaceutical industry.

Keywords: allylic chemistry,heterocyclic synthesis,radical chemistry,palladium chemistry,quaternary carbon stereocenters
Integrative characterisation of Novel adenovirus VECtors aimed at Therapeutic Applications (INVECTA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Croatia,United Kingdom,Spain,Netherlands
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 197800.0
EU funding (EUR): 197800.0
Participants: 6
Project status: SIGNED

Adenovirus based vectors have potential translational and commercial values and are studied as vectors for gene transfer and vaccination . Low seroprevalence adenoviruses are efficacious platforms for vector design, warranting their thorough investigation. Therefore, the main objective of INVECTA is to establish a collaborative effort for the study of scientific problems related to development of novel low seroprevalence adenovirus based vectors aimed at their therapeutic usage, with an emphasis on training both experienced and early stage researchers in adenovirus research, as well as establishing foundation for long term collaboration. As the use of adenoviral based platforms becomes widespread there is a pressing need to develop protocols and methodologies to define the full complement of adenovirus-host interactions, the “adenoviral interactome”, that may limit efficacy and compromise safety. Within INVECTA we aim to increase our understanding of novel low seroprevalence adenovirus vectors with respect to infectivity, structure, stability, receptor usage, tropism, and the interaction with the blood and immune system. This knowledge will allow us to evaluate novel low seroprevalence vectors at the pre-clinical level in areas of unmet clinical need, namely cancer gene therapy and vaccination. INVECTA presents an interdisciplinary and intersectoral network in basic and translational adenovirus research which will foster transfer of knowledge, skills and technology, as well as enable training in the field of basic and applicative adenovirus biology. To maximize knowledge sharing, INVECTA will second researchers within consortium, organize internal workshops and training sessions, and strongly encourage participation in specialized workshops, schools and conferences according to the open science model.

Keywords: adenovirus vector aimed at gene therapy and vaccination