Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Generation of new zebrafish models for the study of the pathogenesis of Huntington´s disease and for the identification of new therapeutic targets. (HUNTINFISH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Huntington´s disease (HD) is one of the nine neurodegenerative diseases (ND) caused by (CAG)n trinucleotide tract expansions that encode abnormally long polyglutamine (polyQ) tracts. The common features shared by many ND are the misfolding and aggregation of toxic proteins. Thus, HD recapitulates features of other, more complicated ND. As HD is an autosomal dominant disorder, modeling this disease in vitro and in vivo is straightforward. Unfortunately, HD is, to date, incurable and there are no drugs or therapies that are known to slow or prevent the disease. Thus, the strategies proposed in this project, taking advantage of the unique characteristics of the zebrafish as model organism to study human diseases, will allow me to gain a deeper understanding of its pathogenesis, and to generate tools to accelerate the development of new therapies. Moreover, my findings may have relevance to other ND. First, I propose to generate new zebrafish transgenic lines expressing different forms of human huntingtin (htt) (wild-type/mutant, full-length/exon1) fused to the photoconvertible fluorescent protein Dendra in whole body, neurons or glial cells using the UAS-GAL4 system. Next, I will validate the construct integration in the fish genome and characterize the transgenic lines. After that, I will use these new generated models to study the life cycles of the previously mentioned forms of htt in vivo, and I will examine their clearance kinetics in vivo in different tissues in the context of inhibition/stimulation of autophagy or ubiquitin-proteasome pathways. Moreover, I will assess the role played by the inflammasome in the context of the neuroinflammation present in HD. Finally, I will use these new zebrafish lines to test novel therapeutic targets recently identified in the host lab, in order to develop new treatments for HD.

Keywords: zebrafish,huntington s disease,neurodegenerative diseases,autophagy,ubiqutitin proteasome pathway
Impact of air pollutants on cutaneous responses in both healthy and compromised skin barrier, and innovative solutions to protect skin against urban pollution (CITYCARE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Switzerland,Belgium,United States
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2017-09-01
End date: 2021-08-31
Duration (months): 48.0
Total project cost (EUR): 773848.08
EU funding (EUR): 773848.0800000001
Participants: 4
Project status: CLOSED

Nowadays, our skin is increasingly more assaulted, as a result of the increasingly complexity of our living environment. Because of its critical location, the skin is continuously exposed not only to natural environmental stress factors, such as UV radiation, ozone and extreme weather conditions associated with climatic changes, but also to pollutants/aggressors of anthropic origin, such as cigarette smoke and diesel/gasoline fuel exhaust. By combining the complementary expertise of the three partners involved in the present consortium, i.e. polymer technology and formulation expertise (DCE), skin barrier understanding and biochemistry/molecular biology (UoF), and impact of diesel/gasoline exhaust on cellular responses (UNIFR), this project will aim (i) at better understanding the consequences of air pollutants on both skin integrity and function, (ii) at investigating the synergistic effects of air pollutants such as ozone, cigarette smoke and diesel exhaust with UV radiation, (iii) at discovering innovative solutions to protect skin against those environmental stressors using both a curative approach based on the optimization of the delivery and efficacy of antioxidant compounds, and a preventive approach, based on the formation of a polymeric barrier film at the skin surface, (iv) at studying the impact of air pollutants on both healthy skin and compromised, damaged skin since the number of individuals suffering from skin diseases such as atopic dermatitis and psoriasis continuously increases with the increasingly level of air pollution and air-conditioning systems. The variety of training offered under this EID proposal will enable three early-stage researchers to build strong S&T background as well as to develop numerous transferable skills for their future career. The present training program will allow the researchers to expand their knowledge to new domains and applications, while also providing good networking opportunities.

Keywords: skin science,environmental insults,ozone,cigarette smoke,diesel,gasoline exhaust,free radicals,skin biomechanics,antioxidants,polymer chemistry,silicone chemistry,atopic skin,psoriasis
Smart Photovoltaic Façades for Self-Powered Buildings (PowerBrise)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Buildings are responsible for 40% of energy consumption and 36 % of CO2 emissions and are an important field of action in the EU. Europe counts with a vast potential volume of 600000 non-residential buildings and more than 70% of the global photovoltaic market, forecasted to reach more than 2.05 billion € annually. PowerBrise comes as a smart solution both to significantly improve the energy self-consumption of large non-residential buildings and to increase their energy efficiency. Synthesis s.r.l. goes a step further in the current state of the art by developing an novel photovoltaic solution for building Façades which integrates for the first time the benefits of : (1) Brise soleil (or louver system), (2) Photovoltaic power and (3) Building Automation Systems (BAS). PowerBrise uses sun radiation to generate power but at the same time lets in some sun light through the semi-transparent cells. Brise soleil by its own increases the comfort inside the building and reduces up to 25% its energy consumption; the integration of photovoltaic cells inside the glass of brise soleil and the smart motorization to automatically follow the sun direction, makes PowerBrise is able to save up 40% of the building energy costs, supplying by means of renewable energy, up to 25% of the energy consumed by the building. We expect that the deployment of PowerBrise in the EU and international markets will allow Synthesis for the exploitation of a business opportunity in new and retrofit installations that will bring cumulative revenues of 30 M€ by 2025, with a ROI of 4.7 and the creation of 37 direct jobs by 2025. This Phase 1 will allow us to ensure that PowerBrise is feasible from a technical and economic point of view, and that its implementation will be a commercial success

Keywords: smart photovoltaics,renewable energy,energy efficiency,motorized brise soleil,architecture,building cladding,building integrated photovoltaics,bipv,shading,intelligent pv module
ASSESSMENT ON ALTERNATIVE AVIATION FUELS DEVELOPMENT (ALTERNATE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Spain,Austria,Spain,Belgium,France,France,France,United Kingdom
Call: Aviation operations impact on climate change (InCo flagship) (H2020-MG-2019-SingleStage-INEA, 2019)
Start date: 2020-01-01
End date: 2022-12-31
Duration (months): 36.0
Total project cost (EUR): 2600387.13
EU funding (EUR): 2600387.13
Participants: 10
Project status: CLOSED

It is widely accepted that the use of sustainable fuels, with a Life-cycle carbon footprint substantially smaller than the present fossil-origin kerosene, is the most promising and probably the only short-medium time measure allowing the aviation industry to reduce its emissions, helping to reach 2015 Paris Agreement targets. During the last 10 years, many tests have been done with different drop-in organic products with high level of success. Present commercial aircraft engines are certified for using a mix of up to 50% of some of these new products. More additional research is still going on the convenience of developing new feedstocks and on their potential climate change impact. The International Civil Aviation Organization (ICAO) is now discussing the best way to standardise the Life-cycle Analysis (LCA) of the most readily available products and what is the best certification procedures. This process is needed in order to apply CORSIA (Carbon Offsetting and Reduction Scheme for International Aviation), approved in October 2016, intending to stabilize international aviation carbon dioxide (CO2) emissions at 2020 levels. However, none of those new organic-origin fuels has proved the means to be produced in an economically competitive way versus fossil kerosene. It is generally accepted that some type of incentive mechanism needs to be implemented to make sustainable fuel attractive for the airlines in addition to the CORSIA and European Trading System provisions. As the result of this Chinese and European cooperation proposal, some possibilities appear for a wider aviation sustainable fuel utilisation, considering both technical and economic areas, including the possible use of more feedstocks and production pathways than the existing ones. New fuel candidates will be evaluated in this project according to improved modelling methods, considering LCA optimization, climate change effects and technical and economic consequences of their use.

Keywords: alternative jet fuel pathways,life cycle analysis,air pollutant emissions
Network of Functional Molecular Containers with Controlled Switchable Abilities (NOAH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Spain,Spain,Germany,Italy,Germany,Spain,Switzerland,Poland,France,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-04-01
End date: 2022-09-30
Duration (months): 54.0
Total project cost (EUR): 2525640.84
EU funding (EUR): 2525640.84
Participants: 13
Project status: CLOSED

NOAH deals with the education of early-stage researchers (ESRs) in a multidisciplinary chemical research program within the area of functional molecular containers, encapsulation processes and their applications with the possibility to end up with a PhD degree. The proposed training network aims to bring in a great variety of scientific attributes to 10 selected ESRs, ranging from the experimental organic and inorganic synthesis to computational chemistry. Photo- and electro-chemistry, MS/gas-phase chemistry, X-ray diffraction and optical spectroscopy techniques will be also included in the scientific formation and development of the recruited ESRs. The trainees will also receive education in complementary and transferable skills through attendance to local and network-wide dedicated training seminars (e.g. dissemination, communication, organization, governance, ethics…). The training program includes the exposure of the ESRs to chemical research carried out in the non-academic sector or in a technological centre by means of full recruitment or short stage secondments in one of the three chemical European companies or the technological centre operating at very different levels: one large company, Covestro, two SMEs, Mind the Byte and Biolitec and one technological centre Leitat. ESRs will also gain insight in the transfer process of knowledge from academia to industry and other complementary soft-skills. The proposed ETN constitutes an ideal framework to acquaint ESRs, in a modest amount of time (3 years), with a great variety of scientific skills, experimental techniques, soft-skills and technologies. Ten ESRs will be incorporated in a multidisciplinary team formed by 7 research groups of multiple nationalities that are focused on a common goal and with high involvement of 3 non-academic partners and one technological centre. All PIs are internationally recognized scientists and the scholar scientists have wide experience as tutors and mentors of ESRs.

Keywords: molecular capsules
Instrumented engine Cradle for the TUrboprop demonstrator ground teSt (ICTUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France
Call: Advanced Instrumented Engine cradle of the Turboprop demonstrator (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-02-01
End date: 2020-07-31
Duration (months): 30.0
Total project cost (EUR): 389156.25
EU funding (EUR): 272409.38
Participants: 1
Project status: CLOSED

ICTUS - Instrumented engine Cradle for the TUrboprop demonstrator ground teSt In the framework of the development of a new turboprop engine demonstrator (WP3 of the ENGine ITD JTP), a full Integrated Power plant System (IPPS) will be ground tested. The objectives of the ICTUS Project are: - To benchmark current turboprop engine installation : the benchmark aims to deliver recommendations/suggestions for an optimize engine installation configurations in line with the ENG ITD objectives (weight savings and performance); - To design the engine cradle for ground tests: a virtual prototype of the engine cradle is developed to predict the static and dynamic behaviour of the cradle in operational conditions; design is conducted to be compliant with CS23 regulation rules; - To manufacture, to instrument and to qualify by test the engine cradle: a tubular structure is manufactured; an instrumentation setup is proposed and installed on the cradle; the relevant position of the sensors for monitoring purpose is set-up based on SAFRAN HE specifications; engine cradle will be testes in the VIBRATEC laboratory to qualify the structure and the instrumentation; - To characterize the engine compartment ventilation system: CFD analysis are conducted to verify the temperature and the air flow exhausted by the engine. The ICTUS consortium is made of the VIBRATEC Company, a French SME, leader in vibration and mechanical analysis. With a double skills in simulation and test, VIBRATEC covers the scope of the technical programs. In design phase, the project will address the dynamic behavior of the engine cradle to mitigate the structural resonance risks and to focus on vibration isolation system. Among others, the ICTUS project will allow to test new kind of sensors based on the Fiber Bragg Grating technologies, a family of optical fiber strain sensor that resists to sever environment especially towards electromagnetic field.

Keywords: turboprop,ground test,cradle design,dynamic loads,vibration damping,fbg sensors
A Holistic Fire Management Ecosystem for Prevention, Detection and Restoration of Environmental Disasters (TREEADS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Innovation actions
Countries involved: Spain,Germany,Spain,Spain,Italy,Germany,Spain,Spain,Italy,Italy,Austria,Austria,Spain,Austria,Germany,Spain,Spain,Taiwan, Province of China,Cyprus,Romania,Romania,Greece,Norway,Greece,Greece,Greece,Greece,Lithuania,Sweden,Norway,Belgium,Bulgaria,Norway,France,Denmark,Denmark,United Kingdom
Call: Preventing and fighting extreme wildfires with the integration and demonstration of innovative means (H2020-LC-GD-2020-3, 2020)
Start date: 2021-12-01
End date: 2025-05-31
Duration (months): 42.0
Total project cost (EUR): 22788345.99
EU funding (EUR): 19258995.18
Participants: 53
Project status: SIGNED

Considering the socio-ecological transition of Europe 2030, and towards a more resilient and informed community, focusing on the forests that are near wildfire risk, TREEADS aims to build upon state-of-the-art high TRL products and unite them in a holistic Fire Management platform that optimize and reuse per phase the available Socio-technological Resources in all three main phases of Wildfires. For the prevention and preparedness TREEADS propose the use of a real-time risk evaluation tool that can receive multiple classification inputs and work with a new proposed neural network-powered Risk factor indicator. To create a model of Fire adapted communities (FAC) in parallel to insurance incentives, TREEADS will use alkali activated construction materials (AAM) integrating post-wildfires wood ashes (PWA) for fire-resilient buildings and infrastructure. TREEADS also uses a variety of technological solutions such as the Copernicus infrastructure, and a swarm of small drones customized for accurate forest supervision. In the area of Detection TREEADS propose a variety of toolsets that will accommodate most needs. Stemming from Virtual reality for the training, wearables for the protective equipment of the emergency responders. to UAV (drones), UAG and airships for improving capacity in temporal and spatial analysis as well as to increase the inspected area coverage.. Last, TREEADS will build a new land and field-based restoration initiative that will use all modern techniques such as agroforestry, drones for seed spread, Internet of things sensors that will be able to adapt the seeding process based on the ground needs and on the same time with the help of AI to determine post-fire risks factors. TREEADS solution will be demonstrated and validated under real operating conditions. Demonstration will involve Eight complex pilot implementations executed in seven EU countries and in Taiwan.

Keywords: holistic fire management system,ai for fire and forest management,restoration technologies
Very Efficient Deep Learning in IOT (VEDLIoT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Switzerland,Sweden,Poland,Portugal
Call: Next Generation Internet of Things (H2020-ICT-2020-1, 2020)
Start date: 2020-11-01
End date: 2024-01-31
Duration (months): 39.0
Total project cost (EUR): 7996646.25
EU funding (EUR): 7996646.25
Participants: 13
Project status: SIGNED

The ever increasing performance of computer systems in general and IoT systems, in particular, delivers the capability to solve increasingly challenging problems, pushing automation to improve the quality of our life. This triggers the need for a next-generation IoT architecture, satisfying the demand for key sectors like transportation (e.g. self-driving cars), industry (e.g. robotization or predictive maintenance), and our homes (e.g. assisted living). Such applications require building systems of enormous complexity, so that traditional approaches start to fail. The amount of data collected and processed is huge, the computational power required is very high, and the algorithms are too complex allowing for the computation of solutions within the tight time constraints. In addition, security, privacy, or robustness for such systems becomes a critical challenge. An enabler that aims at delivering the required keystone is VEDLIoT, a Very Efficient Deep Learning IoT platform. Instead of traditional algorithms, artificial intelligence (AI) and deep learning (DL) are used to handle the large complexity. Due to the distributed approach, VEDLIoT allows dividing the application into smaller and more efficient components and work together in large collaborative systems in the Internet of Things (IoT), enabling AI-based algorithms that are distributed over IoT devices from edge to cloud. In terms of hardware, VEDLIoT offers a platform, the Cognitive IoT platform, leveraging European technology, which can be easily configured to be placed at any level of the compute continuum starting from the sensor nodes and then edge to cloud. Driven by use cases in the key sectors of automotive, industrial, and smart homes, the platform is supported by cross-cutting aspects satisfying security and robustness. Overall, VEDLIoT offers a framework for the Next Generation Internet based on IoT devices required for collaboratively solving complex DL applications across a distributed system.

Keywords: distributed ai,heterogeneous computing,cognitive edge computing
Legal Identity for All? (CitizenGap)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-09-01
End date: 2027-08-31
Duration (months): 72.0
Total project cost (EUR): 1499996.0
EU funding (EUR): 1499996.0
Participants: 1
Project status: SIGNED

Although we often think of undocumented persons as migrants or non-citizens, about one in seven people across the globe lack documents such as birth certificates, ID cards or passports to prove their legal identity, and thus their status as citizens in their own country. This gap between citizens with and without state-recognized documents is just as consequential as the distinction between citizens and non-citizens. Existing approaches portray the citizenship gap – the difference between legal status and the ability of citizens to document their claim to this status – as the apolitical by-product of deficiencies in governance. The proposed research project – CitizenGap – aims to change how scholars and policy-makers think about achieving one of the key targets of the United Nations’ Sustainable Development Goals “By 2030, provide legal identity for all, including birth registration” by developing a novel political understanding. The project establishes the citizenship gap as a field of social scientific research, and pursues two main questions: (1) How and why do states invest in civil registration? (2) How and why do citizens decide to obtain documents? To understand why millions of citizens are undocumented, it is crucial to remember that citizenship is not only a legal status, but first and foremost a political relationship between states and the populations they govern. CitizenGap advances a strategic theory that seriously considers the incentives of states and citizens in the politics of civil registration. Empirically, the project contributes a comprehensive, cross-national measure that captures the number and characteristics of undocumented citizens, including those at risk of having their citizenship status questioned. The project analyzes the origins and nature of the citizenship gap in India and Mexico with a mixed methods design, combining demographic and spatial (GIS) datasets with fieldwork, archival sources, interviews and focus groups

Keywords: birth registration,civil registration,legal identity,sustainable development goals,state capacity,subnational comparative research