Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
System for vehicle-infrastructure Interaction Assets health status monitoring (SIA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Innovation actions
Countries involved: Austria,Spain,Spain,Germany,Spain,Spain,France,United Kingdom
Call: EGNSS Transport applications (H2020-GALILEO-GSA-2017-1, 2017)
Start date: 2018-03-01
End date: 2021-08-31
Duration (months): 42.0
Total project cost (EUR): 3395036.25
EU funding (EUR): 2901948.76
Participants: 10
Project status: CLOSED

SIA has the objective of developing 4 ready-to-use new services (iWheelMon, iRailMon, iPantMon and iCatMon) to provide prognostic information about the health status of the railway’s most demanding assets in terms of maintenance costs (wheel, rail, pantograph and catenary). These new services will help to reduce the 15% of railway maintenance costs, 25% of maintenance unscheduled events and 15% of derailments associated to the rail-wheel interface. These new end-to-end services are supported by a system that will adapt and integrate existing products (TR9) and technologies (TRL5-TRL7) as STEREO®, WINDSepe® and ERSAT_CPS® among others, brought by the consortium. The features of the services rely on an accurate and available positioning that will be achieved thanks to the distinguished characteristics for the railway environment of the EGNOS and Galileo multi-frequency multi-constellation signals (e.g. E5 wideband signal with Altboc modulation has high code range precision through reduced code noise and multipath). SIA will build on existing EGNSS based pilot projects such as H2020-ERSAT EAV and H2020-FR8RAIL within the context of Shift2Rail. SIA will also build on standards and best practice guides (e.g. GEGN8578, IEC613735-2-6, RailTopoModel among others), which will foster EGNSS adoption in the railway environment. Complementary, and with the same importance level to the technical development, SIA has the objective of paving the way for the market uptake of the new services. With this regard, 4 pilot projects has been planned to validate the performance of the new services in fully operational scenarios and to be used as a commercial platform for potential end-users. The preliminary business plans reveals a very promising business potential with a ROI of 126%, an accumulated turn-over of 34M€ in 5 years and acquired income rights of another 58M€ for the 5th year. Three high-tech SMEs are leading the project representing approximately 40% of the project effort.

Keywords: prognostic health monitoring system,wheel,rail,pantograph and catenary,component degradation models,railway maintenance optimization,reduction of derailments,big data visualization platform
Advancing beyond the adaptive radiation paradigm: uncovering the contributions of adaptive and non-adaptive processes to a rapid plant radiation (RadiPhyte)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2022-03-02
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

Understanding why some lineages rapidly generate exceptionally high species diversity (undergo rapid radiation) lies at the heart of our understanding of biodiversity and is a key question in biology. Adaptation to different ecological niches together with rise of phenotypic diversity is considered to trigger rapid radiations. However, existing studies fail to test the alternative (or null) hypothesis, namely that a rapid radiation is driven by non-adaptive processes mediated by geographic isolation of lineages with similar ecological niches. In order to uncover the contributions of adaptive and non-adaptive processes to a rapid radiation, I will focus on the radiation of Dianthus in Eurasia, the most rapid plant radiation known. RadiPhyte aims at developing a novel, integrative perspective on evolutionary radiations, beyond the narrow focus on adaptive radiations, to unravel the driving forces in this plant radiation. RadiPhyte will focus on three key aspects: phylogenomics, ecological niche modelling, and phenotypic trait evolution, and will encompass species from the biodiversity hotspots across the Mediterranean mountains and from the semi-arid/arid mountains of Irano-Anatolia, Caucasus and Central Asia which are not only highly biodiverse but severely understudied and threatened by climate change. RadiPhyte combines the strengths of the host in ecological genomics of adaptive processes in Dianthus, with those of the applicant in phylogenetics, ecological niche modelling, and geometric morphometrics. RadiPhyte will thus promote a two-way transfer of knowledge between the host and the applicant and create important synergies. RadiPhyte comprises a comprehensive dissemination strategy, and is in line with the “climate change action in developing countries with fragile mountainous ecosystems from a sub-regional perspective” of the EU with the aim to integrate the knowledge gained in the continental arid regions with those available within Europe.

Keywords: adaptation,biogeography,conservation,evolutionary radiation,geometric morphometrics,macroevolution,mountain biodiversity,niche evolution,niche conservatism,phylogenomics
Mitochondrial membrane-targeted compounds for cancer therapy (mitozippers)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-07-01
End date: 2019-12-31
Duration (months): 18.0
Total project cost (EUR): 149700.0
EU funding (EUR): 149700.0
Participants: 1
Project status: CLOSED

Cancer is one of the leading causes of death in Europe. The economic impact of cancer in Europe has been quantified with a total cost of 126 billion €, including healthcare costs and productivity losses. Although many efforts have been devoted to eradicate cancer, the current treatments are associated with severe side effects and high toxicity. Alternatively, the next generation of cancer treatments targets only malignant cells, which exhibit unique biochemical hallmarks different from their normal counterparts. For example, cancer cell mitochondria are structurally and functionally different from healthy cells. As mitochondria are the waterline of cellular viability, they represent a more effective therapeutic target as compared to current protein targeted therapies. Here, we propose a novel approach whereby the control of cell proliferation and survival is achieved by means of regulation of the membrane properties of the cancer cell mitochondria by means of a lipophilic cationic drug, which efficiently accumulates in mitochondria. Our approach meets the requirements of developing, protecting and commercializing alternative therapies leading to an improvement of life quality and survival rate of cancer patients as well as an improvement in economic terms.

Keywords: targeted cancer therapy,mitochodrial membranes,membrane biophysics,drug delivery
Crack-Defined Nanogap Electrodes for High-Throughput Decoding of DNA (MaMs3)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Sweden
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-11-01
End date: 2020-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Within the ERC Starting Grant project M&M´s we have developed several innovative fabrication and integration technologies for nanoelectromechanical systems (NEMS). In one of these research activities, our ERC team has invented and demonstrated a new methodology for parallel fabrication of electrically conductive electrode pairs separated by sub-2 nm wide gaps, enabling unprecedented fabrication of millions of such nanogap electrodes. To the best of our knowledge, there is no alternative technology available with comparable capabilities. We have identified next generation DNA sequencing using electron tunneling detection as a high-impact application that could be enabled by our nanogap electrode fabrication methodology. Sequencing of the genome of individual patients is vital to realize the potential of truly personalized medicine. However, current DNA sequencing technologies are still too slow and expensive for sequencing genomes for healthcare practice on a large scale. There is, therefore a critical need for a new sequencing platform that has the potential to sequence the full human genome within 1 hour for less than €100. DNA sequencing based on electron tunneling detection (quantum sequencing) is one of the most promising next-generation sequencing technologies that could reach this target. However, there currently is no technology available to fabricate, in a scalable fashion, large numbers of electrode pairs with 1-2 nm wide gaps that are integrated in nanopores. As a possible solution to this problem, our nanogap electrode methodology is addressing a potential multi-billion € market. In this ERC-PoC project we will develop business and IPR strategies for commercial exploitation of our nanogap electrode methodology. Furthermore, we will develop initial proof-of-concept demonstrations of DNA detection events using nanogap electrode devices, which will be important for attracting interest from industry and possible investors.

Keywords: nanogap electrodes,electron tunneling detection,dna sequencing,nanopore sequencing
A MOBILE SUPER HIGH FREQUENCY EQUIPMENT TO PRODUCE HIGHLY DISPERSED NANOSORBENT IN REAL TIME BASED ON THERMALLY EXPANDED GRAPHITE FOR LIQUIDATION OF NATURAL AND MAN-MADE ACCIDENTS (OILCS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ukraine
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-07-01
End date: 2018-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The Oil Catchpot System (OilCS) – an innovative mobile solution for Thermally Expended Graphite based on nanosorbents production directly on or near the site of oil spills. It provides: Quick localization of oil spot, Quick binding of oil products, Convenient collection of bound oil products, Return of oil products, Absence of wastes, Universal application, Environmentally friendliness of exploitation, Efficiency of application – volumes of sorbent during its storage and transportation are reduced in 80 times.It is characterized by the very long-term storage of raw materials, circular use of resources (recovery of spilled oil up to 90%, use of spent sorbent as secondary raw materials), reduction to "0" financial costs associated with the payment of compensation for caused damage and restoration of contaminated areas. This solution brings to the oil spill management market new, innovative, environmentally safe and cost-effective integrated system for the on-the-spot collection of oil spill generated by different anthropogenic accidents. As a result of bringing the technology to the market, end users will get: - an actual cost-effective solution for the liquidation of oil spills; - prevention of environmental pollution; - this system does not require drastic changes in oil spill management, as it easily complements existing technologies and is easy to operate. Given equipment use doesn’t change processes of spills management, but it completes and improves it. INECO`s further intentions are: to proceed with OILCS as a mobile clean up unit for soils (coastal and seashore lines) remediation, and to clean oil settling from the water bodies bottom, to develop for potentially dangerous objects of infrastructures Contrameasure Plans based on the use of OILCS. Using OILCS companies will not depend on natural, climatic, engineering conditions and long distance of site from the coastal supply bases. It will allow them to reduce delivery time of means&mechanisms for spills.

Keywords: oil spills,clean up techniques,nanosorbents,ecofriendly,zero waste production,resource efficiency technology
Supporting the Electric Vehicle REVOLUTION through maximising EV Range and End-of-Life Vehicle Recovery through optimisation of recycled plastics and advanced light materials (REVOLUTION)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Germany,Germany,Spain,Germany,Spain,Italy,Ireland,Türkiye,Thailand,Norway,Belgium,Finland,Türkiye,France,Netherlands
Call: Advanced light materials and their production processes for automotive applications (H2020-LC-GV-2020, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 5927475.0
EU funding (EUR): 4997912.63
Participants: 17
Project status: SIGNED

REVOLUTION focusses on overcoming the challenges hindering the use of recycled materials, but more broadly, restricting the widespread adoption of circular economy principles in the automotive industry. Forthcoming ELV directives are expected to recognise the potential for plastics to enable a circular flow of materials in the automotive sector. Implementing minimum post-consumer recyclate (PCR) targets in any new plastic components in vehicles are currently being discussed. These targets will disrupt the automotive industry. Currently PCR (closed-loop recycling) forms ~2% of the total plastics demanded across the automotive sector, and are not used in high-value or high-performing areas. REVOLUTION is proposing a disruptive innovation that will bring open-loop recycling to the forefront of automotive injection moulding. The variability of PCR causes a big problem for an industry where failure rates on 1 per million are accepted. REVOLUTION will use machine learning and artificial intelligence to optimise the input of recycled materials and injection moulding process to deliver high-quality parts. The AI-Platform will use data from three areas of the production process to predict part quality when using recycled materials. REVOLUTION will develop this platform, and develop a range of recycled formulations, including self-reinforced materials to deliver innovative components that offer light weighing, superior performance and distinctive end of life advantages for future EVs. REVOLUTION brings together leading organisations from European strong-hold industries such as automotive, chemicals and plastics. The automotive industry is represented by Fiat Chrysler Automobiles through Tofas, CRF and Tier 1s Farplas and MAIER. LyondellBasell, Clariant and Altuglas provide strong representation of the European excellence in plastics and chemicals. These are joined by leading research organisations and SMEs to bring a solution to market that addresses the entire value chain.

Keywords: circular economy,ecodesign,end of life,recycled pmma,recycled pp,cradle to cradle machine learning,elv directive,self reinforced polymers
European Doctoral programme on ENergy and Environment (EDENE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: France
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2019, 2019)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 4881600.0
EU funding (EUR): 2440800.0
Participants: 1
Project status: SIGNED

The European Doctoral Programme in Energy and Environment (EDENE) is a multidisciplinary, intersectoral and international ambitious project over a 5 years duration offering a quality training to 30 international and highly skilled PhD Fellows in the field of Energy and Environment. Since the University of Pau and Pays de l’Adour (UPPA) obtained in 2017 the excellent label I-site (competitive Initiative Science/Innovation/Territories/Economy by the French Programme Investments for the Future) for its project Energy & Environment Solutions (E2S), UPPA’s priority is to develop international collaborations with targeted universities, to attract new talents, and to develop the international courses offer, mainly in Energy and Environment areas. Using its comparative plus points in terms of location (Pyrenean cross-border France/Spain region), UPPA developed cross-border collaborations and sound partnerships with international companies located in the south west region of France. EDENE was born from these collaborations and gathers leading expertise from a strong consortium: two universities (UPPA, University of Zaragoza), international companies (TOTAL, Enedis, Bertin, Teréga) competitive clusters (POLE AVENIA) and Technology Transfer Office (Aquitaine Science Transfert - AST). EDENE intends to address two major European Societal Challenges SC3 “Secure, clean and efficient energy” and SC5 “Climate action, environment, resource efficiency and raw materials”, by enabling promising Early Stage Researchers to achieve excellent research applied to energy and environment areas in mathematics, engineering, geosciences, aquatic environments, computer sciences, land development, treatment of economic data, or physical-chemistry.

Keywords: energy,environment,mathematics,engineering,geosciences,computer sciences,physical chemistry,land development,economics
Chair/bedside diagnosis of oral and respiratory tract infections, and identification of antibiotic resistances for personalised monitoring and treatment (DIAGORAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Switzerland,Sweden,France,Czechia,Netherlands,Netherlands,United Kingdom
Call: Development of new diagnostic tools and technologies: in vitro devices, assays and platforms (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-06-01
End date: 2019-05-31
Duration (months): 48.0
Total project cost (EUR): 5588101.25
EU funding (EUR): 4721198.5
Participants: 11
Project status: CLOSED

The project aims at diagnosing oral and respiratory tract infections (RTIs) using a fully integrated, automated and user-friendly platform for physicians’ offices, schools, elderly care units, community settings, etc. Oral diseases (periodontitis, caries) will be detected via multiplexed, quantitative analysis of salivary markers (bacterial DNA and host response proteins) for early prevention and personalized monitoring. RTIs (e.g., tonsillitis, pharyngitis, rhinitis, sinusitis) will be diagnosed by means of DNA/RNA differentiation so as to identify their bacterial vs viral nature. Together with antibiotic resistance screening on the same platform, a more efficient treatment management is expected at the point-of-care. High impact is expected on socioeconomic level too, as the healthcare system is expected to benefit from: less crowded hospitals (patients find equally efficient chair-side diagnosis); less budget spent on excessive antibiotics and progressed-stage disease treatments; less insurance costs for oral diseases, which are largely age-related. At the heart of DIAGORAS lies a centrifugal microfluidic platform (LabDisk and associated reader) integrating all components and assays for a fully-automated analysis: interface of the collection tube with the disposable disc; on-disc sample preparation (nucleic acid extraction and purification with pre-stored buffers); amplification & detection (rapid PCR); protein isolation and detection (bead-based multiplexed immunoassays); microarray-based antibiotic screening. Low-cost disposable fabrication (microthermoforming of polymer foils) will render the platform batch-producible and affordable to end users. The entire setup will be validated at clinical settings and compared with gold standards (e.g., tissue extraction and culture methods). The modular nature of the platform, the non-invasive sampling, the rapid and multiplexed molecular-based detection, and the sample-to-answer analysis are DIAGORAS innovative features.

Keywords: antibiotic resistance,caries,centrifugal microfluidics,diagnostics,lab on a chip,multiplexing,periodontitis,point of care,quality control,respiratory tract infections,saliva
Ion-irradiation-induced Si Nanodot Self-Assembly for Hybrid SET-CMOS Technology (IONS4SET)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Germany,Finland,France
Call: Generic micro- and nano-electronic technologies (H2020-ICT-2015, 2015)
Start date: 2016-02-01
End date: 2020-07-31
Duration (months): 54.0
Total project cost (EUR): 3999205.0
EU funding (EUR): 3999205.0
Participants: 6
Project status: CLOSED

Billions of tiny computers that can sense and communicate from anywhere are coming online, creating the “Internet of Things” (IoT). As the IoT continues to expand, more and more devices need batteries and plugs. According to Gartner (www.gartner.com), there will be nearly 26 billion devices connected to the IoT by 2020. Therefore, together with improved batteries, advanced computation and communication must be delivered at extremely low-power consumption. It is well-known that Single Electron Transistors (SET) are extremely low-energy dissipation devices. CMOS and SETs are complementary: SET is the champion of low-power consumption while CMOS advantages like high-speed, driving etc. compensate exactly for SET's intrinsic drawbacks. Unrivalled integration with high performance is expected for hybrid SET-CMOS architectures.Manufacturability is the roadblock for large-scale use of hybrid SET-CMOS architectures. To assure room temperature (RT) operation, single dots of diameters below 5 nm have to be fabri-cated, exactly located between source and drain with tunnel distances of a few nm. A reliable CMOS compatible process of co-fabrication of RT-SETs and FETs is not yet available. IONS4SET will pave the way for fabrication of low-energy devices operating at RT using the discovery of a bottom-up self-assembly process. Lithography cannot deliver the feature sizes of 1…3 nm required for RT operation. IONS4SET will provide both, (i) controlled self-assembly of single ~ 2 nm Si dots and (ii) self-alignment of each nanodot with source and drain at tunneling distances of ~ 2 nm. The fabrication process of the Si nanodot involves (i) ion irradiation through a few tens of nm thin Si pillars with an embedded SiO2 layer and (ii) thermal activation of self-assembly. Dot self-assembly works for narrow pillars only, i.e. nanopillar fabrication is crucial for IONS4SET. Finally, a power saving hybrid SET/CMOS device with a vertical gate-all-around nanowire GAA-SET will be fabricated.

Keywords: low power electronics,self assembly,si quantum dots,single electron transistor set,hybrid set cmos technology