Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Making Books Talk: The Material Evidence of Manuscripts of the Kitab al-Shifa by Qadi Iyad (d.1149) for the Reception of an Andalusian Biography of the Prophet between 1100 and 1900 (MASHQI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-01
End date: 2019-01-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

This project will examine the manuscripts of a biography of the Prophet Muhammad (d. ca. 632), written by the Maliki jurist Qadi ‘Iyad (d. 1149), in order to elucidate the historical context of the work’s enduring popularity with Muslim readers. The Kitab al-shifa’ fi ta‘rif huquq al-Mustafa (The book of healing concerning the recognition of the true facts about the chosen one) circulated widely both inside and outside the Islamic West. A large number of manuscripts, written between the 13th and the early 20th century, are known to be extant, but no autograph has been preserved. The project will approach the work’s manuscripts as material evidence for how readers engaged with the text and for how their interpretation evolved over time. Drawing on the methodologies of codicology and critical bibliography, as developed by literary critics and cultural historians for research on Medieval and Renaissance Europe, the manuscript analysis will document changing modes of production, transmission and reading. In order to advance the integration of Digital Humanities into Middle Eastern and Islamic Studies, Open Source tools will be employed to map the circulation of al-Shifa’ copies. Since Qadi ‘Iyad is one of the authorities of Maliki Islam in North Africa, the research will be conducted at the Consejo Superior de Investigaciones Cientificas (CSIC) in Madrid under the supervision of Prof. Maribel Fierro, an international authority of the history of the Islamic West. The results will be published as an interpretative study, accompanied by a database of al-Shifa’ copies and a visualization of their circulation; the three parts will be available Open Access on the CSIC website. Analyzing the material evidence preserved by al-Shifa’ copies will provide major new insights into Muslim approaches to the veneration of the Prophet Muhammad since the Middle Ages, thereby refocusing the discussion of whether in Islam religious education stands in the way of progress and modernization.

Keywords: iberia,al andalus,north africa,sunni islam,malikism,sufism,prophet muhammad,sirat al nabi,hagiography,hadith,islamic manuscript,codicology,book history,reception studies,arabic
Infant Theory of Mind (INTOM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Croatia
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2024-02-01
Duration (months): 24.0
Total project cost (EUR): 170010.0
EU funding (EUR): 170010.0
Participants: 2
Project status: SIGNED

The project aims to advance knowledge of the development of Theory of Mind - the ability to reason about other’s beliefs. Specifically, the project will combine brain imaging techniques with adaptations to typical Theory of Mind tasks that will allow major theoretical advances in the understanding of infant social cognition. The use of brain imaging techniques to study the development of Theory of Mind is an upcoming research strategy made possible by recent advances in lower-cost infant appropriate techniques such as function Near Infrared Spectroscopy and places this project at the cutting edge of the field. Previously the experienced researcher has sought to evaluate the mechanisms underpinning corvid’s and children’s social behaviours and the Supervisor has independently sought to evaluate the mechanisms underpinning responses to complex social stimuli. The current project uses their joint backgrounds to facilitate the development of innovative behavioural paradigms that, in combination with the use of imaging techniques pioneered by a collaborating research lab, will allow the team to address key questions in infant Theory of Mind research. In addition to the research aspects of the proposal the project will allow the experienced researcher to learn to use imaging techniques on infants and will involve the dissemination of research through publications and conference talks. Furthermore, both the experienced researcher and Supervisor will continue their commitment to undertaking public engagement programs and are excited about exploring the new opportunities for exploiting their research that the project ensues.

Keywords: theory of mind,developmental psychology
Origen on Gender. The feminine as an intellectual category in the works of Origen of Alexandria. (OriGen)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2024-03-30
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: SIGNED

My project aims to investigates to what extent Origen of Alexandria used the feminine as an intellectual category, that is, as a rhetorical and literary code for expressing theological doctrines. The majority of studies on women and gender have only marginally discussed the works of such a renown third century theologian, since Origen does not fit the dichotomous paradigm of research in this field, traditionally divided between “gender studies” and “women’s studies”. Rather, he employed the feminine as a philosophical and theological category to express his trinitarian, anthropological and ecclesiological doctrines. My project will be conducted in three following steps, each one focused on a specific objective. First, I will identify and list all the occurrences in which the feminine is employed as an intellectual category in Origen’s literary production. Secondly, I will contextualise these passages within Origen’s overall theology. Thirdly, I will identify antecedent traditions which held similar beliefs about the feminine and from which Origen could have drawn. I am well suited for this task, as I am trained in historical theological methods of investigation and have already conducted research on feminine imagery in early Christianity. Moreover, my project is innovative in the field as there are only a handful of studies which considers the feminine as an intellectual category, and none of them concerns Origen of Alexandria. Aarhus University is the perfect match to my project, as my proposed supervisor (Prof. Anders-Christian Jacobsen) is an expert on Origen of Alexandria and the other members of staff are experts in Origen’s reception history and trained in literary analysis of early Christian texts.

Keywords: origen of alexandria,early christian studies,patristics,historical theology
EXPLORING NEW HALO-AUTOTROPHIC PATHWAYS FOR THE DEVELOPMENT OF A NOVEL COST-EFFECTIVE DUAL METHANE AND CARBON DIOXIDE ELIMINATION TECHNOLOGY (ENHANCEMENT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

Nowadays, CH4 and CO2 emissions represent approximately 90% of the total greenhouse gas (GHG) inventory worldwide, and their share is expected to increase due to their industrial and organic-based nature as well as the increasing world population. The European Union, due to the urgent need to maintain global average temperatures 2ºC below pre-industrial levels, has developed clear targets in the Horizon H2020 climate actions based on building a low-carbon, climate resilient future as well as greening the economy. This situation requires intensive research on novel, cost-effective, and environmentally friendly bio-technological strategies for GHGs treatment focused on creating a climate-neutral scenario and a green economy. In this context, the ENHANCEMENT project fulfill these requirements with the simultaneous bioconversion of both CH4 and CO2 into the most expensive compound produced by microorganisms – ectoine (14,000 $ kg-1) – using halophilic ectoine producers from the genus Halomonas. This is the first and only technology that can abate both GHGs simultaneously, resulting only in water, cells, and resting metabolites with a high market value. However, the market uptake of this biotechnology requires: 1) unravelling the metabolic pathways that allow the members of the Hallomonas genus to transform CH4 and CO2 simultaneously into ectoine, and 2) testing the biotechnological potential of this new platform capable of creating value out of GHG mitigation through its implementation under discontinuous and continuous operation in high mass transfer bioreactors. In this context, the ENHANCEMENT project represents a multi- and inter-disciplinary investigation focused on achieving the Horizon H2020 goals through developing a sustainable GHG bioeconomy. Moreover, it will also strengthen the applicant’s curriculum and provide her with the soft skills required to take the next step of her scientific career towards becoming an R3 – Experienced Researcher.

Keywords: halomonas,climate change mitigation,dual ch4 and co2 treatment,biotechnology,ghgs bioconversion,ectoines production,green economy
Investigating the impact of meditation training on mental health and wellbeing in the ageing population (MEDIT-AGEING)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Switzerland,Belgium,France,France,France,France,United Kingdom,United Kingdom,United Kingdom
Call: Promoting mental wellbeing in the ageing population (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2022-03-31
Duration (months): 75.0
Total project cost (EUR): 7087230.46
EU funding (EUR): 6134756.25
Participants: 14
Project status: CLOSED

As the number of older people in Europe grows, increasing healthy life years is a priority. Cognitive decline, dementia (e.g. Alzheimer’s disease, AD), sleep disturbances and depression, all related to psychological distress and anxiety, are significant drivers of reduced quality of life in older adults. This project builds on evidence that lifestyle factors and meditation practice have the potential to downregulate these adverse factors and positively impact mental and neurological conditions including AD. Our main objectives are i) to improve early AD detection and understanding of physiopathological mechanisms; and to investigate ii) the impact of internal/external (e.g. genetic and lifestyle) determinants and iii) the effect and mechanisms of action of meditation training, on mental health and wellbeing in older people. This will be achieved by using pre-existing databases from European partners and conducting two randomized controlled trials (Studies 1 and 2B) and one observational study (2A). STUDY 1 will assess the short-term effects of an 8-week meditation intervention (versus cognitive training) in patients with subjective cognitive decline at risk for AD on behavioural measures including anxiety and wellbeing. STUDY 2A will assess senior expert meditators to identify neural signatures of different meditation practices on attention and emotion regulation tasks. STUDY 2B will assess long-term effects of an 18-month meditation intervention (versus an active control) on behavioural and biological markers of mental health and wellbeing in cognitively intact elderly. The cognitive and affective regulatory mechanisms underlying these effects will be investigated using the neural signatures identified in the expert meditators. High public health relevance is likely: the proposed intervention targets the most common mental and neurological conditions in the elderly and it can be scaled up within preventive programmes at a population level.

Keywords: meditation,ageing,alzheimer s disease,neuroimaging,lifestyle,wellbeing,emotion,cognition,attention,biomarkers,mental health,sleep,dementia,prevention
Crystal Engineering the New Generation of Sustainable, Biocompatible and Stimuli Responsive Formulations for the Delivery of Active Ingredients (CryForm)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy,United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1963562.0
EU funding (EUR): 1963562.0
Participants: 2
Project status: SIGNED

CryForm aims at progressing our fundamental knowledge in organic materials crystallization and crystal engineering by: (1) gleaning a mechanistic understanding of the relationship between crystal structure and surface properties; (2) uncovering the thermodynamic and kinetic mechanisms of crystal nucleation and growth at liquid/liquid and liquid/gas interfaces; (3) understanding the role of large biomolecules in the modification of crystal growth and nucleation kinetics. This knowledge will enable the design of novel sustainable, biocompatible and stimuli responsive multiphase formulations (e.g., emulsions, foams) for the encapsulation and controlled release of active ingredients. Developing formulations with enhanced dissolution rate and bioavailability is critical for many industrial sectors: about 40% of the active pharmaceutical ingredients on the market and 60% of the ones in development are poorly soluble or scarcely bioavailable. Agrochemicals and food nutraceuticals present similar problems. Currently, synthetic excipients, surfactants and specialty polymers are used to create formulations with enhanced properties. However, these compounds are derived from non-renewable resources through some of the most greenhouse gas-intensive manufacturing processes. The production and incineration of polymeric materials will produce, in 2019, more than 850 million metric tons of greenhouse gases. Furthermore, the chemical synthesis of many polymers involves highly toxic, flammable and polluting reagents such as ethylene oxide, responsible for the 2004 explosion at Sterigenics International in California. It is clearly necessary to move away from polymer-based formulations and find more sustainable and safer alternatives. CryForm proposes a unique approach whereby synthetic additives will be replaced with natural crystals specifically engineered to enable controlled release of active ingredients via a unique mechanism based on stimuli-triggered solid form transformations.

Keywords: crystal engineering,formulation science,drug delivery
Reconstitution of the basic molecular mechanism of phagocytosis – a bottom-up synthetic biology approach (minimal-phagocyte)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The ability of cells to engulf large objects, such as invading microorganisms or apoptotic cells, is crucial to innate immunity and tissue remodelling. The molecular basis of this process - phagocytosis - is complex, involving numerous receptors and signalling pathways. Nevertheless, the biophysical process is always the same: the cell membrane deforms and reshapes to wrap around the particle, and upon closure and abscission of the resultant cup, the particle is internalised. Although the key molecular players in individual phagocytic pathways have been identified, we still know very little about the basic biophysics common to all phagocytic pathways. I propose to fill this gap in our knowledge by creating a “minimal phagocyte”: I aim to reconstitute a minimal, dynamic actin cytoskeleton and artificial phagocytic receptors in giant unilamellar vesicles (GUVs), thereby identifying the molecular components that are not only necessary but also sufficient for phagocytosis. Using synthetic biology to build a bottom-up model of phagocytosis should answer many open questions, including: are spatial cues resulting from particle binding required for membrane wrapping around the particle? Is directed initiation of actin polymerisation sufficient to render GUVs capable of phagocytosis? What is the role of the membrane-supporting actin cortex and how does the affinity of the receptors affect the engulfment process? Beyond phagocytosis, the minimal-model approach I propose will also be useful to study other cellular functions requiring actin-driven membrane reorganisation, such as cell mobility. In line with the objectives set by ERA-NET ERASynBio and the Horizon 2020 work programme (which identified synthetic biology as one of the “cutting-edge biotechnologies as future innovation drivers”), the creation of “protocells” will not only enhance our understanding of biology, but ultimately also result in novel biotechnological applications, such as improved drug delivery systems.

Keywords: membrane biophysics,biomimetics,in vitro reconstitution,synthetic biology,phagocytosis
NeMo : Hyper-Network for electroMobility (NeMo)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Germany,Italy,Italy,Italy,Austria,Germany,Germany,Germany,Spain,Spain,Italy,Italy,Italy,Italy,Belgium,Greece,Poland,Romania,Hungary,Slovakia,Greece,France,Netherlands
Call: Electric vehicles’ enhanced performance and integration into the transport system and the grid (H2020-GV-2015, 2015)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 7836827.04
EU funding (EUR): 7836827.04
Participants: 39
Project status: CLOSED

Electromobility is a major factor towards transport decarbonisation. However a number of challenges (limited charging options, lack of interoperability, absence of a unified identification/payment process, energy grid overload, expensive charging tariffs) limit the potential for interoperable and seamless electromobility services to a wider of actors and geographic area, hindering electromobility adoption. These challenges stem from lack of standardisation in electromobility data and services. NeMo addresses all issues through a pan-European eRoaming Hyper-Network that allows seamless and interoperable use of electromobility services throughout Europe. In addition it provides an Open Cloud Marketplace, where third parties can provide services (B2B2C) aiming to increase EV attractiveness. The NeMo Hyper-Network is a distributed environment with open architecture based on standardised interfaces, in which all electromobility actors, physical (i.e. CPs, grids, EVs) or digital (i.e. CPOs, DSOs, etc.), can connect and interact seamlessly, exchange data and provide more elaborate electromobility ICT services in a fully integrated and interoperable way both B2B and B2C. The connection will be based on dynamic translation of data and services interfaces according to needs of the specific scenarios and involved stakeholders. NeMo is not just another proprietary platform for electromobility but a full open eco-system allowing continuous and uninterrupted provision of data and services. NeMo will raise awareness, liaise with standardisation bodies and contribute to the evolution of protocols and standards by developing public Common Information Models which incorporate all existing electromobility related standards and constantly update them to reflect standards evolution. NeMo will also propose sustainable business models for all electromobility actors opening new opportunities for SMEs and EU Industry.

Keywords: b2b b2c ict services,electromobility interoperability,common information model,pan european eroaming,open cloud marketplace,ev energy cycle management,battery management system,smart grid