Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Control mechanisms and robustness of multicellular symmetry breaking (BREAKDANCE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,France,Spain,Austria
Call: ERC Synergy Grants (ERC-2022-SYG, 2022)
Start date: 2024-01-01
End date: 2029-12-31
Duration (months): 72.0
Total project cost (EUR): 10259926.0
EU funding (EUR): 10259926.0
Participants: 4
Project status: SIGNED

Understanding the establishment of an animal body plan is an important challenge of modern biology. Progress has been mainly limited by (1) a separation of research fields studying genetic and biophysical mechanisms, and (2) a lack of approaches to mimic multicellular tissue organization from first principles. In a cross- disciplinary effort, we will focus on the earliest stages of animal development, when first steps of cell differentiation define the primary body axis through spatial symmetry breaking, laying the foundation for the future body plan. Our goal is to identify the fundamental mechanisms controlling this symmetry breaking process. To this end, we will study in detail the interplay between global tissue geometry (shape, size, and dimension), physical boundary conditions, and mechano-chemical cell interactions. Therefore, we address the following questions: (i) How do global shape and size control local cellular states and interactions? (ii) How do local cellular states and interactions induce robust symmetry breaking at the tissue level? (iii) To which extent can geometry control cell fate specification in a species-independent manner? To overcome previous limitations, we will establish a comprehensive methodological toolbox of synthetic bottom-up approaches and functional ex-vivo assays. We use as model systems mouse, zebrafish, and later also human embryonic stem cells. This will be combined with advanced biophysical techniques and theoretical modeling in order to systematically dissect the mutual couplings between genetic patterning mechanisms and morphogenetic processes, thereby revealing the multicellular dance underlying tissue symmetry breaking. Our results will shed new light on the long-standing question of how complex biological forms are robustly built from a single fertilized egg, impacting on our understanding of organism development and maintenance, and opening new directions for the controlled design of artificial tissues and organs.

Keywords: biological self organization,tissue patterning,quantitative approaches to mechano chemical signalling,cell and tissue mechanics,size and shape in biology
Decentralised Direct Air Capture The most sustainable, affordable and scalable way to produce clean CO2 on demand (DDAC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 3545125.0
EU funding (EUR): 2481587.5
Participants: 1
Project status: SIGNED

Finalist of the 2021 KVK innovatie Top 100, with the Solar Impulse Efficient Solution label, finalist at Connect22, winner at Japan's Plug & Play 2023 and spun off from the European Space Agency, Skytree is a Climate Tech company developing small-scale carbon capture solutions to produce clean CO2 directly where it is needed. The unique size of our decentralised direct air capture (DDAC) units opens up new multi-million opportunities in sectors where fossil fuels-based CO2 supply is increasingly expensive and uncertain, e.g. greenhouse farming (our beachhead market), CO2 feedstock, and many more. The modular architecture of our DDAC units allows the deployment of easily scalable 100% custom plug-and-play CO2 production systems, while waste heat integration will allow reducing energy consumption and OPEX. Our ambition is to drive the use of clean CO2 to boost crop yield while ending reliance on fossil fuels, thus guaranteeing more resilient, sovereign and sustainable greenhouse farming.

Keywords: carbon capture,decentralised direct air capture,food sovereignty,resilient agriculture
Barents Sea Arctic Cenozoic Evolution and Paleogeographical Reconstructions (BRAVO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway,Australia
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 306232.8
EU funding (EUR): 306232.8
Participants: 2
Project status: SIGNED

This project "Barents Sea Arctic Cenozoic Evolution and Paleogeographical Reconstructions (BRAVO)" aims to reconstruct the Barents Sea Gateway since the Cenozoic (the last 66 Myr). To do so, BRAVO’s objectives are to 1) reveal the effect of sediment loading–unloading, lithospheric strength, and surface-mantle processes on shaping the Cenozoic paleobathymetry-topography of Barents Sea, to 2) constrain the timing of the formation of the BSG, to 3) identify the interplay between climate dynamics and tectonics in erosion and deposition of sediments in the paleo-Barents Sea, and (4) compare the development of the BSG and Fram Strait, as well as the regional to global consequences of the Arctic-Atlantic shallow water connection. BRAVO will achieve these objectives by numerical modelling (inc. finite element and volumetric methods) using open-source platforms of pyGPlates, pyBadlands and high-resolution 2D–3D seismic, well, gravity and magnetic data analyses. BRAVO’s results will be self-consistent 4D Earth models (space and time) of paleobathymetry-topography of Barents Sea Gateway and corresponding sedimentary pathways and accumulation. BRAVO’s ambition is to provide the most reliable paleobathymetric-topographic reconstruction of the Barents Sea Gateway for the Cenozoic. BRAVO will quantify the role of Barents Sea Gateway in exchanging Atlantic–Arctic water, highlight the significance of erosion–deposition of sediments in shaping the gateway, and form the basis for updated global oceanographic and climatic simulations. BRAVO’s pioneering model of the complete Cenozoic source-to-sink analysis for the regional Barents Sea will be a breakthrough for Arctic seabed characterization for offshore wind turbines and mapping slope failure geohazards.

Keywords: arctic,seismic,stratigraphy,geosciences
MSCA Presidency Conference 2025: Attracting and retaining talent in Europe (ART)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Coordination and support actions
Countries involved: Denmark
Call: Presidency event: MSCA Conference under Danish Presidency 2025 (HORIZON-MSCA-2025-DNK-IBA, 2025)
Start date: 2025-05-01
End date: 2025-12-31
Duration (months): 8.0
Total project cost (EUR): 149999.5
EU funding (EUR): 149999.5
Participants: 1
Project status: SIGNED

Denmark will assume the presidency of the Council of the EU in the second half of 2025. The Technical University of Denmark (DTU), as requested by the Danish Ministry of Higher Education and Science, will organise the annual Marie Sklodowska-Curie Actions (MSCA) Presidency Conference. The event will be held 18-19 September 2025, at DTU Campus in Lyngby, just north of Copenhagen. Project and conference organisation will be managed by the DTU under the umbrella of the Danish Presidency, which oversees all high-level research and innovation conferences organised during the presidency semester. With the title MSCA Attracting and Retaining Talent in Europe (ART), the conference has the overall aim of fostering human-centred discussions on purposefulness, motivation, expectations and demands from current and future generations of researchers in their working-life – and how we can attract and retain an excellent workforce in research in Europe. The conference will give specific emphasis to purposefulness, motivation, and means to foster a diverse and inclusive work culture, including well-being. As the academic landscape continues to evolve, the conference aims to examine how universities can adapt to meet the expectations of early-career researchers (ECR), including Millennials and Gen Z, who seek balance between professional growth and personal well-being. By bringing together key stakeholders, the conference will explore the purpose-driven motivation of future generations and share insights on promoting academic fairness, diversity, and equality. Contributing to the competitiveness and attractiveness of European universities, in collaboration with industry and public bodies, to future generations of top talent, this discussion will support the continued excellence of European research and innovation.

Keywords: ecrs,academic work culture and working life,coara,intersectoral mobility
Preparation of a joint action plan to support the emergence and growth of silver ECOnomy European ECOsystems and strengthening their efficiency, capacity, interconNECTivity and inclusivity. (Senior Eco-Nect)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: France,Ireland,Spain,Belgium,Slovenia
Call: Preparatory action for setting up joint programmes among innovation ecosystems actors (HORIZON-EIE-2021-CONNECT-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 497325.0
EU funding (EUR): 497325.0
Participants: 6
Project status: CLOSED

Senior Eco-Nect project will prepare a joint action plan to support the emergence and the development of European ecosystems dedicated to silver economy as well as ensuring the inclusivity and interconnectivity between all the key innovation stakeholders of the sector and cross-sectors. The specific objectives of Senior Eco-Nect are the followings: O.1 – Support the emergence, growth, efficiency, and interconnection of at least 4 European ecosystems dedicated to silver economy. O.2 – Unlock the full potential of silver economy sector by integrating key transversal areas targeting the ageing population beyond the scope of health and care. O.3 – Ensure inclusiveness and interconnectivity between the key innovation players from across the quadruple helix around the sector of silver economy at the local, regional, national, and European level and beyond O.4 – Increase the efficiency and innovation potential of silver economy innovators and projects by addressing key challenges and exploiting the opportunities offered by silver economy O.5 – Encouraging synergies and complementarities between Senior Eco-Nect Joint Action Plan and the innovation programmes of public authorities Six partners representing innovation ecosystems and sectoral networks will join forces and strategies toward the strenghthening of european innovation ecosystem in silver economy: Eurasanté in France, Munster Technological University in Ireland, Slovenian Innovation Hub in Slovenia, Cluster Saude de Galicia in Spain, the European Platform for Sports and Innovation, and the European Network for Accessible Tourism. Their effort will be supported by the engagement of 32 associated partners representing key innovation ecosystems members of the quadruple helix (industry, academia, public authorities and civil society across Europe.

Keywords: joint action plan efficiency capacity interconnectivity inclusivity peer learning analysis strategy building silver economy seniors ageing innovation ecosystems quadruple helix
The role of area-based conservation measures in reducing impact from agriculture, conserving biodiversity, and supporting local communities’ livelihood (ProtectedTrade)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: TERMINATED

Pressures on natural landscapes due to soybean and cattle ranching have been increasing in Brazil over the last decades. This is largely driven by exports, including to the European Union, making these commodities some of the most important threats to biodiversity and non-timber forest products. Some of these products can be used for medicinal and food security purposes by local communities, and often are managed either by women or men differently. Area-based conservation measures are an important global conservation strategy and include the newly defined “other effective area-based conservation measures” (OECMs). OECMs can play a larger role in nature conservation in areas managed by local communities, yet it remains unclear to what extent they are contributing to conservation. This project will evaluate the impact of soybean and cattle expansion in Brazil on biological and cultural diversity and gender, and the contribution of OECMs on their conservation. Specifically, I will (i) identify species used by local communities and assess their conservation status as well as potential gender-differences in their uses; (ii) analyze the impact of soybean and cattle ranching expansion on biocultural diversity and the potential gender-biased consequences; and (iii) evaluate the contribution of different OECM-types to the conservation of cultural and biological diversity. To do that, this action will combine methods and techniques across disciplines (literature review on the relationship between species and gender) and geoprocessing and statistical analysis (land-use change and matching analysis). Expected results include three scientific publications and outreach activities to amplify societal awareness about the impact of agriculture on culture and nature and provide evidence of how OECMs can support both biodiversity and the livelihood of women and men, being considered as a promising conservation tool in the next decade.

Keywords: biocultural diversity,commodity trade,land use change,area based measures,amazon,cerrado,effectiveness,oecm
A combined photoelectrochemical and fluorescence imaging system for investigating nanoparticle-cell interactions (NANO-PEFIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-02
End date: 2026-09-01
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: SIGNED

Nanoparticles (NPs) have become increasingly attractive for biomedical applications such as targeted drug delivery, cancer therapy, and bioimaging due to their excellent properties. The investigation of NP-cell interactions (cellular uptake and cytotoxicity) is crucial to the development of safe and effective use of NP in living organisms. However, current methods for studying NP-cell interactions rely on fluorescence microscopy, and complementary methods need to be done separately. Therefore, we propose to develop a novel imaging system that can conduct label-free photoelectrochemical imaging and fluorescence imaging simultaneously so that electrical signals from the basal side of cells and fluorescence signals can be obtained in tandem. A laser with a suitable wavelength will be used as the excitation source for both fluorescence and photocurrent. This imaging system will be validated by monitoring cell viability with fluorescence assay and photocurrent imaging, and by monitoring the cellular uptake of model NPs to correlate the physicochemical properties of NPs to their uptake efficiency and toxicity. These validation experiments will be compared with established techniques. This system will be used to study neuron-NP interactions to reveal the mechanism of NPs’ functional effects in neuronal activities. The combined imaging system will help us gain a deeper understanding of NP-cell interactions and will offer a label-free method for assessing the toxicity of NPs in the biomedicine field. Therefore, this project will facilitate the rapid development of safe and effective nanomedicines and nano-delivery systems that allow site-specific, target-oriented delivery of precise medicines to treat and prevent various diseases. This will significantly increase the impact of nanomedicines in the clinic, increase the quality of life for an ageing population and help us respond to public health emergencies effectively.

Keywords: photoelectrochemical imaging,fluorescence imaging,nanoparticles,cell nano interactions,cellular uptake of nanoparticles,neurotoxicity
REsponsive and REconfigurable value network for the manufacture of bulky parts (REED)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Spain,Luxembourg,Norway,Greece,Germany,Denmark,United Kingdom,Italy
Call: Manufacturing as a Service: Technologies for customised, flexible, and decentralised production on demand (Made in Europe Partnership) (RIA) (HORIZON-CL4-2024-TWIN-TRANSITION-01, 2024)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 6433095.72
EU funding (EUR): 5295168.13
Participants: 14
Project status: SIGNED

The demand of large and complex part manufacturing is growing rapidly in the capital goods sectors, such as energy generation, yellow goods or railway, due to increasingly required energy generation efficiency, larger infrastructures and cost effective means of transport, respectively. The manufacturing process of bulky parts usually involves high labour intensity workpiece handling and set up, as well as a final assembly stage. Many of these tasks are completed manually and this occasionally leads to low precision, low efficiency, poor stability, and high physical burden. Difficulties in the manufacturing of bulky parts result in a shortage of companies capable of producing components within the required standards, even when they have the production equipment to do so. The homologation process of subcontractors is very sensitive and it is usually based on a trust relationship between customer and supplier. Manufacturers' accessibility to auxiliary equipment for workpiece setup, handling and modelling is cumbersome and based on word of mouth, leading to rigid supply chains and a lack of flexibility to find alternative partners. This rigidity in the supply chain of bulky components contribute to the need to identify, monitor, and reconfigure traditional supply chains into more flexible and responsive value networks, in order to effectively address supply chain distresses. The main objective of REED project will be the development of a Manufacturing as a Service (MaaS) platform that will provide the enabling technologies, equipment and services for the manufacturing of bulky parts of the capital goods sector, assuring the quality of the produced components while maximising productivity and minimising environmental impact. The REED platform will redefine the B2B relationships through a networked digital productive model.

Keywords: maas servitisation of assets value chain optimisation bulky parts
Unraveling how evidence accumulation determines conscious experience using voltammetry (volta)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 1992959.0
EU funding (EUR): 1992959.0
Participants: 1
Project status: SIGNED

Consciousness entails the phenomenal experience we have of the world and ourselves. Although it is at the heart of major philosophical, scientific and ethical issues, our understanding of the neural mechanisms of consciousness remains limited. The study of consciousness is compartmentalised, with researchers focusing on isolated sub-aspects of the problem, via restrictive paradigms that ignore the temporal dynamics of conscious experience, its metacognitive component, or its dependence on levels of consciousness. Moreover, we know virtually nothing about the single-neuron and neurochemical basis for consciousness in humans. VOLTA will advance beyond these empirical and theoretical limitations by conducting a multidimensional and multiscale study of consciousness. The project builds on a computational framework I recently developed linking consciousness to evidence accumulation. It will utilise the clinical context of pharmaco-resistant epilepsy to collect unprecedented behavioural and neural data. Individuals with epilepsy will participate in novel behavioural paradigms quantifying multiple dimensions of conscious experience, including its temporal dynamics, metacognitive components, and existence under sleep and anaesthesia. These experiments will be combined with triple neural recordings that simultaneously characterise #1 the global activity of neural populations, #2 spiking activity of individual neurons, and #3 electrochemical activity by measuring neuromodulator release with voltammetry. These unprecedented recordings will provide a multiscale map of the neurobiological basis of consciousness. My team and I, assisted by international experts, will interpret this rich dataset in light of seven preregistered hypotheses derived from my computational framework. In summary, VOLTA will carry out a first-of-a-kind within-subject study to reveal the electrophysiological and electrochemical mechanisms of the multiple dimensions of consciousness.

Keywords: electrophysiology,metacognition,computational modelling