Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Directing the immune response through designed nanomaterials (DIRNANO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Spain,Italy,Italy,Switzerland,Norway,Netherlands,United Kingdom,United Kingdom,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 4007724.48
EU funding (EUR): 4007724.48
Participants: 12
Project status: SIGNED

DIRNANO provides a highly integrated and interdisciplinary training of next-generation Early Stage Researchers (ESRs) at the interface of nanopharmaceutical bioengineering and its translation on preclinical and human immunology. DIRNANO will develop biocompatible nanopharmaceuticals with either “super”-stealth or immune-specific behavior for cancer immunotherapy and vaccination by mapping nanoparticle-immune interactions through two core approaches: 1) inception of novel surface engineering approaches, based on new organic polymers, zwitterionic lipids and conjugation chemistry strategies, 2) engineering of host or microbial-derived modulators of innate immunity (e.g. complement system). DIRNANO team comprises internationally renowned scientists and industrialists at the forefront of nanoengineering, pharmaceutical sciences, molecular biosciences, commerce and business, thereby generating a unique pan-European macro-environment for interdisciplinary training of ESRs at the highest international level. Through participation of industrial partners, we will furnish ESRs with in-demand industrial and business skills, including process manufacturing, reproducibility and regulatory challenges, intellectual property and commercialization strategies. DIRNANO will lead to rational engineering of broader libraries of NPs with tunable immune-modulating functions. The combinatorial analysis of new nanomaterial core-coat scaffolds will improve temporal and spatial understanding of biomaterial-innate immune interactions at the molecular level, thereby filling the void in overcoming adverse reactions to nanopharmaceuticals injection. DIRNANO will drive future development of small molecules and biologics-based nanopharmaceuticals through a “low-risk-high gain” perspective and within the context of personalized therapies and precision medicine. As such, DIRNANO, will extensively contribute to European science, education and socioeconomics value, skill retention and brain-gain.

Keywords: nanomedicine nanobiotechnology,innate immunity complement system,core shell nanoparticle design,stealth nps,polymer lipid np coats,apc targetting,tumor therapy,tumor vaccination
ASSIST - Support Network for Household Energy Saving (ASSIST)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Italy,Italy,Spain,Spain,Belgium,Poland,Belgium,Belgium,Finland,United Kingdom
Call: Engaging private consumers towards sustainable energy (H2020-EE-2016-CSA, 2016)
Start date: 2017-05-01
End date: 2020-06-30
Duration (months): 38.0
Total project cost (EUR): 1649370.0
EU funding (EUR): 1649370.0
Participants: 12
Project status: CLOSED

ASSIST is a 38 month European ‘market activation - policy orientation’ project to tackle fuel poverty and support vulnerable consumers. It answers the call requirements to actively engage consumers in the energy market and positively change behaviour in relation to energy consumption and to influence design of policy at all levels to tackle fuel poverty issues. Based on the conclusion of the “Energy Citizens’ Forum”, it combines activities that address both energy and social issues as fuel poverty is not only an energy issue nor can it be tackled in isolation of the bigger issue of poverty, it will: Broaden understanding on European fuel poverty incidence and how energy support services are effectively tackling the issue, identify best practice and needs but also provide a baseline against which the activity can be compared to demonstrate its effectiveness and to inform work towards policy orientation. Create an European network and build this by ensuring quality knowledge and skills of the Vulnerable Consumer Energy Advisors (VCEA) with a supportive infrastructure for professional development and experiencing sharing. The VCEA will be in positions of direct contact with the target group in order to help mainstream energy services and, increase access and uptake for the fuel poor. The creation of the VCEA network will also encompass the recruitment of persons with direct experience of vulnerability/fuel poverty, training them to increase their employability skills but, moreover, to maximise on the peer to peer benefits that they can offer in provision of advice . With specialist VCEA and advisory strategic steering committees each nation will undertake target actions to address the specific issue. In this way the action utilises the powerful effect of target group ownership of action + bespoke solutions designed in collaboration with the target groups/end users to deliver important lessons learned for dissemination and policy influence.

Keywords: vulnerable consumers,energy poverty,domestic energy consumption,energy reduction,behavioral change
Origins of a new Economic Union (7th to 12th centuries): resources, landscapes and political strategies in a Mediterranean region (nEU-Med)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Italy
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-10-01
End date: 2021-05-31
Duration (months): 68.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Medieval archaeology over the past thirty years has challenged the canonic history of the rise of Western Europe. First, the collapse of the Roman world in Italy by the 7th century was more profound than had been previously envisaged by historians, leaving rural society, in particular, maintaining comparatively primitive conditions. Secondly, in complete contrast, north-west Europe by stages between the 7th and 9th centuries developed an integrated economic union. Central to this was agricultural intensification coupled with strategic deployment of a silver currency. Thirdly, between the 9th and 12th centuries certain regions of Italy, drawing simultaneously upon connections to the north as well as the Mediterranean, became the economic and political motor of the new Medieval Europe, paving the way for the Renaissance. This project aims to make a paradigmatic shift in understanding the archaeology of resource management and commerce in the revival of the Medieval Mediterranean. The investigation will define how an inter-connected micro-territorial system occupying a classic riverine corridor in an area of Tuscany, first entered the west European post-Roman economic arena, and then, by steps over time, how these contributed to the emergence of major urban communes such as Pisa in 12th-century Tuscany. Drawing upon twenty-five years of multi-disciplinary research by different teams from the University of Siena, the new project, based in Siena, supported by a group of expert researchers, post-doc and PhD students, aims to examine these questions by undertaking a co-ordinated programme of research based upon survey archaeology, science-based archaeology, new archival research and environmental science. These data will provide a model for the integration of this region into the wider European economic union and the micro- and macro-political strategies involved.
Microbial Uptakes for Sustainable management of major bananA pests and diseases (MUSA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Spain,Ethiopia,Spain,Italy,Cuba,Belgium,Costa Rica,United Kingdom,Kenya,Nigeria
Call: Challenges for disease management: Perennial crops in the tropics and sub-tropics (H2020-SFS-2016-2, 2016)
Start date: 2017-06-01
End date: 2021-11-30
Duration (months): 54.0
Total project cost (EUR): 3987403.75
EU funding (EUR): 3987403.75
Participants: 14
Project status: CLOSED

Nematodes and weevils of banana with Panama disease globally affect food security, causing yearly crop losses for many billion € in Canary Islands, Caribbean and Africa. These threats concomitantly affect crops in tropical and sub-tropical systems. In regions such as Sub Saharan Africa (SSA) millions of farmers rely on cooking banana, plantain and ensete as starch staple food crops and for income. Pesticides no longer represent a sustainable option for control, and many have been progressively withdrawn from use in the EU or are highly restricted, due to harmful effects on the environment and toxic residues. In SSA, where phytosanitary policies and regulations are often less effective, such pesticides are still being (mis)used, posing a significant threat to vulnerable farmers and consumers. In the absence of long term strategies or suitable control methods, and under the influence of changing climates in tropical and subtropical regions, the banana crops are becoming ever more exposed to pathogens and pests due to higher multiplication rates and prevalence induced by temperatures and rainfall patterns. The principal outcome of this project will be to achieve sustainable intensification of Musa spp. and ensete crops, through identification, development and implementation of IPM based on beneficial microorganisms. MUSA proposes, in a holistic view, IPM methods based on microbial consortia and banana germplasm, studying the plant reactions (phenotypic and molecular) to different biotic stresses. This will be achieved by screening, testing and evaluating in the field, selected banana lines, in an attempt to identify (via transcriptomic analyses) the principal genes involved in driving a resistant/succumbent response, and the interaction with beneficial microorganisms. The latter include endophytes and biocontrol agents (EBCAs) integrated with plant germplasm to develop information-based IPM strategies through field trials.

Keywords: banana,biocontrol,endophyte,fusarium,gene expression,insect,nematodes,resistance,weevil
BLACANDI can improve life quality and cut cost of diagnosing and managing bladder cancer in half (BLACANDI)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Denmark
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The BLACANDI project aims to dramatically improve the diagnosis and management of bladder cancer patients by substituting a highly invasive and expensive test with a non-invasive and inexpensive test. Bladder cancer is the 6th most common cancer with an estimated 357,000 new cases worldwide every year, of which 180,000 are European. This type of cancer has the highest lifetime treatment costs per patient (pp) of all cancers. This high incidence, coupled with it’s relapsing nature, means that bladder cancer poses an enormous burden on health care systems. Current diagnostics and recurrence routine tests are performed through highly invasive and expensive procedures, such as cystoscopy. The Danish SME Genomic Expression Aps has licensed a technology composed of a patented filtration device that enhances the selection of tumor cells in urine, and aims at the clinical validation of a new combination of biomarkers. Our solution BLACANDI (Filtration Device in combination with selected biomarkers) is currently being tested in a small clinical trial in Denmark, in patients presenting with hematuria (blood in urine). Preliminary results indicate that the test can substitute cystoscopy identifying more than 90% of all bladder cancer patients. Substituting routine cystoscopy with the BLACANDI system could cut the cost of diagnosis and managing bladder cancer in half. In Europe the cost of diagnosing bladder cancer is €1.8 billion/year, thus we could save €900 million. Whereas the technology behind the filtration device and the selected biomarkers is already demonstrated, further maturation of the tests into fully commercial and operational solutions is hampered by the absence of a large clinical validation of the BLACANDI system. Furthermore, there is a need to corroborate our business strategy, since it requires customization to different health care systems. This phase 1 feasibility study provides us that opportunity.

Keywords: bladder,cancer,diagnostic,recurrence,medical device,methylation,non invasive,cost reduction,early detection
SpacePharma Microgravity Miniature Pump (SPuMP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Israel
Call: SME Instrument (H2020-SMEINST-2-2015, 2015)
Start date: 2016-02-01
End date: 2017-07-31
Duration (months): 18.0
Total project cost (EUR): 1294500.0
EU funding (EUR): 906150.0
Participants: 1
Project status: CLOSED

SPuMP is a proposal for developing the SpacePharma Microgravity Miniature Pump (SPuMP), with on reservoir temperature control to a technical readiness level of six for use in space based micro-/millifluidic experiments. SPuMP is unique in that it will have pulsation free flow, highly accurate flow control, and on reservoir temperature control for reagent stability. When used in conjunction with the SpacePharma advanced lab, complex, remote controlled, end-to-end fluidic based experiments can be performed in a variety of microgravity platforms, most notably on nano-satellites. The pulsation free flow enables a new set of experiments, such as direct droplet based macro-molecular crystallization, to be performed in the microgravity environment. Enabling temperature control on the reservoir itself, enables reagent stability that is unprecedented. With the use of a battery reagents can be stored at 4 degrees celcius and then warmed up to their useable temperature before beginning an experiment. SPump, while being developed to initially take 5% of the estimated 1000 experiments based on micro-/millifluidic in the microgravity research market each year, also has a wide range of uses in the portable micro-/millifluidic system market, such as with point of care devices, due to its compact size, smooth flow, and ease of filling when already integrated into a closed system. SPuMP allows SpacePharma to open up new avenues to our customers by allowing never before done experiments to be done in the microgravity environment. It also attracts new customers to the European space market who have not previously considered microgravity based research due to the numerous limitations of the currently available pumps on the market for microgravity based research.

Keywords: syringe pump,microfluidics,millifluidics
INTEGRATED PERSONALIZED CARE FOR PATIENTS WITH ADVANCED CHRONIC DISEASES TO IMPROVE HEALTH AND QUALITY OF LIFE (ADLIFE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Innovation actions
Countries involved: Germany,Spain,Israel,Spain,Germany,Spain,Poland,Sweden,Belgium,Türkiye,United Kingdom,United Kingdom,United Kingdom,Denmark
Call: Large Scale pilots of personalised & outcome based integrated care (H2020-SC1-DTH-2019, 2019)
Start date: 2020-01-01
End date: 2024-06-30
Duration (months): 54.0
Total project cost (EUR): 7372526.4
EU funding (EUR): 6379670.88
Participants: 17
Project status: SIGNED

Due to population ageing and advances in medical science, people with chronic diseases –including advanced severe life-threatening chronic diseases- live longer. Challenges are how to sustain quality independent living for the patient; support caregivers facing an increasing burden; create sustainable healthcare and social care systems with limited resources. ADLIFE aims to provide a solution for the integration of therapies and approaches targeting early detection and assessment of deterioration, advanced and well-coordinated care planning and integrated supportive care to enhance quality of life, reduce suffering and accelerate recovery for these patients and their families. It will deploy developed and validated personalised digital solutions for integrated supportive care based on H2020 projects C3-Cloud and Power2DM, previously tested in two health systems. The ADLIFE Toolbox solutions include: a Personalised Care Plan Management Platform, Clinical Decision Support Services; Interoperability Solutions and Patient Empowerment Platform with Just-In Time Adaptive Intervention Delivery Engine. The ADLIFE system will be deployed through large-scale pilots in 7 countries and Health Systems, involve 577 healthcare professionals from 75 hospitals, clinics and primary care services. It will prove that intelligent, collaborative digital solutions can enable care teams, patients and caregivers to improve or better maintain health in patients with advanced chronic disease (over 200,000 in the participating regions). It will test its effectiveness in 882 patients and 1243 caregivers. ADLIFE will demonstrate significant outcomes-based efficiency gains in health and care delivery enhancing seamless care coordination, avoiding gaps and overlaps in care. The ADLIFE ICT Toolbox and the evidence behind this digitally-enabled approach from the 7 reference sites will be strongly disseminated to multiple stakeholders and decision makers in Europe both online and in-person actions

Keywords: large scale deployment,personalized empowerment platforms,clinical decision support systems,advanced chronic diseases
On the maximum energy of particles accelerated in astrophysical jets (EMAXSHOCK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Astrophysical jets moving in an external medium produce shocks where particles can be accelerated via Diffusive Shock Acceleration (DSA). The main uncertainty is the maximum energy that particles can achieve, and this has important implications for different fields in astrophysics. In particular, one of the most exciting problems is the origin of the Ultra High Energy Cosmic Rays, and jets from Active Galactic Nuclei (AGN) have been proposed as candidates. At lower energies cosmic rays are likely galactic. With that respect, a large fraction of gamma-ray sources in the Galaxy remain unidentified, and protostellar jets are among candidates to be the hidden cosmic ray accelerators. It was very recently demonstrated that mildly relativistic shocks in the backflows in the lobes of AGN jets can accelerate particles up to the Hillas energy, offering a suitable environment for the acceleration of UHECRs. However, in order to account for the heavy composition of the UHECR spectrum, a jet mass loading mechanism is needed. At lower energies, acceleration of TeV particles in protostellar jets can be quenched by ion-neutral collisions, and therefore kinetic calculations are desirable in order to compute the maximum energy of particles in low velocity shocks and non-completely ionized plasmas. I will investigate the maximum energy that particles can achieve when they are accelerated via DSA in mildly-relativistic and low-velocity shocks, in AGN and protostellar jets, respectively. In the former case I will consider the shocks produced by the interaction of powerful stellar winds with the jets, whereas in the latter case we will consider the jet termination shocks. By performing unprecedented calculations with the a newly developed hybrid code, I aim to address the maximum energy and composition of the UHECR spectrum by modeling the backflows of jet/wind interactions. In addition, I aim to address if protostellar jets can accelerate TeV particles and emit gamma rays.

Keywords: particle acceleration,shocks,magnetic field amplification,gamma rays
Operationalising telecouplings for solving sustainability challenges related to land use (COUPLED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria,Austria,Germany,Spain,Germany,Germany,Switzerland,Belgium,Switzerland,Belgium,Sweden,Netherlands,United States,Netherlands,United Kingdom,Denmark,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-01-01
End date: 2022-06-30
Duration (months): 54.0
Total project cost (EUR): 3839615.98
EU funding (EUR): 3839615.98
Participants: 20
Project status: CLOSED

Society depends on land for food, feed, fibre and energy, but the detrimental outcomes of unsustainable land practices are becoming increasingly apparent. Ensuring sustainable land use is a key challenge, yet hard to achieve in today’s interconnected world where policies, consumer demands and environmental change in one region may affect far-away places. We face a significant knowledge gap regarding the processes related to land use that link distant places – or telecouplings – and how these processes could be governed towards sustainability. Companies, institutions and policy makers lack the expertise and tools to ensure sustainable land use in a globalised world. COUPLED will educate researchers and entrepreneurs in assessing and governing land use in a systemic way, accounting for the opportunities and threats arising from distal links between Europe and other regions. COUPLED builds on a strong interdisciplinary network to achieve its overall objective of operationalising the novel telecouplings concept in order to support sustainable governance of land systems and related supply chains under global change. COUPLED will deliver on training a new generation of professionals and entrepreneurs, developing rich analytic tools and new understandings to help private and public organisations to identify where and how they can intervene to make sustainable land use decisions, thereby avoiding unwanted outcomes. The consortiums unites scientifically excellent partners across the natural and social sciences to ensure excellence in research, institutional and technological innovation. Working closely with large companies, SMEs, NGOs, international organisations and administrative bodies, the ESRs will learn how to move between science and practice, become highly attractive to employers, and build successful careers in research, consulting, industry or governance. The action will thus contribute to Europe’s leading position for a transformation towards sustainable land use.

Keywords: land use change,sustainability science,telecouplings,globalisation,feedback flows,land system science,globalization,sustainable land management,sustainable supply chains