Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Shaping the Mechano-Pharmacological properties of Microparticles and Extracellular Vesicles for the Treatment of Osteoarthritis (MEPHOS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Israel,Italy,United States,Portugal
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-04-01
End date: 2025-09-30
Duration (months): 66.0
Total project cost (EUR): 952200.0
EU funding (EUR): 864800.0
Participants: 8
Project status: SIGNED

Osteoarthritis (OA) is a chronic disease involving the degeneration of articular cartilage and subchondral bone. It represents the single most common cause of disability in older adults. Being aging, obesity, trauma and gender risk factors for OA, its societal burden is rapidly rising. Across EU, over 40 million people are affected by OA. Current treatment options aim at modulating the symptoms rather than curing this chronic disease. Consequently, joint replacement continues to be ultimately the sole option. In this context, MEPHOS aims at realizing an integrated strategy for OA treatment based on the intra-articular deposition of hydrogel, polymeric microplates (uPLs) that could simultaneously provide a long-term pharmacological action and mechanical support. To this end, the uPL geometry and mechanical properties will be rationally selected to match the viscoelastic behaviour of cartilage and synovial fluid. Over the course of several weeks, uPLs will sustainably release clinically-approved molecules for pain management and novel small molecules and biologicals; including chemokine and metalloproteinase inhibitors to halt tissue degeneration; glycoproteins, growth factors and stem cell-derived extracellular vesicles to favour tissue regeneration. MEPHOS involves three EU Academic Institutions and a SME for uPL fabrication, and four US Academic Institutions for uPL biological and preclinical characterization. Through interdisciplinary and intersectoral secondments, this project will support the training of EU scientists on sophisticated in-vitro assays and three different preclinical OA models; foster the rational development of uPLs; and instil a translational research culture to bridge preclinical-clinical boundaries. The inclusion of a SME and the Stanford SPARK Translation program documents MEPHOS ambition to develop technologies that could hit the clinic and an industrial market, which is predicted to growth from $1.6 billion in 2016 to $3.5 billion by 2026.

Keywords: nanomedicine,drug delivery,musculoskeletal disease,aging
Low Temperature Ceramics Applications (LTCeramics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Finland
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-01-01
End date: 2016-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

In this ERC PoC project, materials and methods developed in “Printed Electroceramics with Ultimate Compositions” will be utilised to demonstrate the feasibility of dielectric ultra-low temperature ceramics as basic electrical components realised on polymer, metal foil and paper substrates. The aims are to realise a set of capacitors and microwave antennae utilising high permittivity ceramic coatings as integral structures (without gluing, adhesives, etc. of discrete components) of aforementioned 3D substrates. In addition, the IPR strategy will be created and potential markets analysed for these components..

Keywords: ceramics,ultra low sintering,capacitor,antenna,printable electronics
High Efficiency wiReless CMOS transceiver boosted by artificial intelligencE for 6G bandS and beyond (HERMES)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Austria,Belgium,Greece,Lithuania,France,France
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 3271457.5
EU funding (EUR): 3271457.5
Participants: 7
Project status: SIGNED

The future of wireless communications will go beyond connecting people or things to connecting smart robots or unmanned vehicles without human intervention. Only sub-THz frequencies can offer the spectrum to achieve unprecedented communication throughput. Yet current technologies suffer from barriers that prevent mass-market operations, such as high cost, limited bandwidth or power-hungry hardware not compatible with autonomous systems. HERMES proposes the fusion of Artificial Intelligence (AI) and deep sub-micron CMOS technology to open a new generation of wireless transceivers. The project will focus on sub-THz frequencies between 140 and 160GHz, and will break new ground in the conversion of information from digital to THz using European CMOS technology to develop a highly integrated transceiver. For the first time, HERMES will deliver to the telecommunications industry a disruptive way of designing transceivers, with impact on production of billions of units that can be implemented in any autonomous system to communicate. This new wireless link will be a springboard for an innovation leap in the robotics and the security industry. Our ambitious and risky approach goes significantly beyond the SoA: we will demonstrate that the power of AI developed by computer sciences research and associated with an original electronics signal processing technique can push CMOS technology to release outstanding performances. The project will produce a chipset of a low-cost radio that exchanges tens of Gbps and will test it in use cases of unmanned vehicles applied to maritime border surveillance operated by civil authorities. The HERMES consortium brings together 6 partners from 5 European countries bridging the full value chain of academic research, technology transfer and industry.

Keywords: sub thz communications,artificial intelligence,deep submicron cmos technology,walsh signal processing,rfic,wideband,smart robots
Identification of novel substrates for ubiquitin ligases involved in cell cycle and cell migration (LIGER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-10-09
Duration (months): 24.0
Total project cost (EUR): 154720.8
EU funding (EUR): 154720.8
Participants: 1
Project status: CLOSED

Cancer cells heavily rely on the proteasome-ubiquitin system mediated tuning of proteins stability and proteome composition. Proteasome and ubiquitin ligases targeting drugs are already in use against certain haematological cancers, and similar inhibitors are currently explored as a possibility for autoimmune diseases and parasite infestation treatment. E3 ubiquitin ligases are the ultimate target for these therapies as they determine specificity in substrate recognition. It is thus of utmost interest for both basic and translational research to find new ubiquitin ligases essential for cell proliferation, cell migration or cancer progression and couple them with their substrates. In the proposed LIGER project, we aspire to fuse cutting-edge methods to identify new ubiquitin ligase – substrate pairs. In particular, we will focus on E3 ubiquitin ligases involved in cancer progression and more specifically, in its two crucial aspects - cell growth and cell migration. To pre-select the ubiquitin ligases for further analysis, we will perform an unbiased screen for ubiquitin ligases that are involved in cell growth and cell migration. To achieve this goal, CRISPR library screening methodology will be employed. Consequentially, we will purify proteins associated with the selected ubiquitin ligases and identify their potential substrates. Standard biochemical and molecular biology methods will allow us to study in detail the protein interface between the ubiquitin ligases and their novel substrates and describe the biological function of their degradation. LIGER project will increase our understanding of ubiquitin pathway in physiological and pathological conditions and identify new potential targets for cancer therapy.

Keywords: cell cycle,therapeutic target,ubiquitin ligase,proteasome,substrate,cancer
Circular European Economy Innovative Training Network (CircEuit)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway,Sweden,Sweden,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2016-09-01
End date: 2020-08-31
Duration (months): 48.0
Total project cost (EUR): 3991638.8
EU funding (EUR): 3991638.8
Participants: 11
Project status: CLOSED

Circ€uit – the Circular European Economy Innovative Training Network - creates a cohort of future leaders in research, policy & business through its innovative training programme focused on the Circular Economy. Circular business models, based on leasing or providing functionality rather than products, often called Product Services Systems, are widely seen as a way how business can create sustainable jobs and growth. The Ellen MacArthur Foundation (EMF) and McKinsey calculated that circular business will create billions of value. This opportunity has become an important development area for researchers engaged in the sustainability, engineering and design and business fields. Seven top universities well embedded in the EIT KIC Raw materials, supported by the EMF, their CE100 network and various companies propose here a multi-disciplinary approach to ensure a range of research perspectives are included across the circular field. 5 main areas of research are relevant to understand how to create such business models. 1. Businesses and business models: how to stimulate circular provisioning? 2. Supply chains: how to organize supply and delivery chains for circularity? 3. Users: how to motivate stimulate circular consumption? 4. Design: how to design circular value propositions? 5. Systems: How to ensure economic and environmental benefits can support for change to circularity? We choose these areas as our main Work Packages, and appoint PhD students in each of these areas with as main goals: 1. Create new business model innovation across Europe that helps to support the economy while at the same time reduce ecological burden 2. Create a new, sustainable and cross-disciplinary network of trained experts who will have the skills, qualifications, and professional connections to drive future innovation. 3. Create new links between industry and academia in training ESRs to develop new approaches to PSS which will help orgs to compete, create growth and innovation.

Keywords: resource efficient economy,circular business models,product services systems pss,multi disciplinary approach
Identifying genes involved in microRNA turnover in Arabidopsis (miRTurnOver)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

MicroRNAs (miRNAs) are small non-coding RNA molecules regulating the expression of protein coding genes by targeting mRNAs. Since they play key roles in development and in responses to both biotic and abiotic stresses, it is important that miRNAs are expressed at the right time and place. Therefore there must be a mechanism to degrade miRNAs (miRNA turnover) and that mechanism itself must be carefully regulated to ensure that miRNAs are not present when their function is not required. However, we know very little about this mechanism and its regulation. I propose carry out a mutant screen and identify genes involved in miRNA turnover. The screen builds on previous work of the host laboratory where miR395, a sulfur starvation-induced miRNA, was characterised. The screening assay relies on a sensor, which is a phloem-expressed GFP transgene containing a miR395 target site, to monitor the level of miR395. Expression of miR395 will be induced by low level of sulfur to down-regulate GFP expression. After replenishing the media with sulfur, miR395 transcription is switched off and the existing miR395 molecules will be degraded, leading to green fluorescence recovery in the seedlings. The speed of this recovery is about three days in wild type plants and I will screen for lines exhibiting faster or slower recovery. After validation of the mutant phenotype I will identify the mutatnt genes by either next generation sequencing or classical map-based cloning. Identifying genes involved in miRNA turnover will open up a new fiekd in the RNA silencing area. Understanding the function of those genes and how miRNA turnover is regulated will impact on all aspect of plant biology but also on biomedicine as siRNAs are potential theraputics.

Keywords: microrna,arabidopsis,mutagenesis
Exploring the biogeography of thermal acclimation in heterotrophic microbes (TRAIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Understanding the biological mechanisms governing carbon (C) exchanges between terrestrial and atmospheric C pools, and how these exchanges will respond, and feed back, to climate warming, are among the most urgent challenges for climate and ecosystem scientists. Heterotrophic microbes are dominant biochemical engineers in terrestrial ecosystems, governing the flux of C between terrestrial and atmospheric pools. Despite concerns that rising atmospheric temperatures will stimulate the respiratory release of C by heterotrophic microbes, recent work highlights the potential for thermal acclimation to partially ameliorate this positive feedback. The magnitude and efficiency of this physiological response is, however, highly variable, suggesting that the strength of climate-ecosystem C feedbacks will vary across landscapes. The proposed study uses a combination of trait-based and community-scale approaches to explore the relative importance of microbial community composition and climate conditions in governing patterns of acclimation potential across landscapes. Incorporating this microbial physiological information into Earth System Models (ESMs) is essential if we are to predict global patterns in biogeochemical cycling under current, and future climate scenarios. The proposed work incorporates aspects of microbial physiological biology, community ecology and ecosystem ecology to address a critical uncertainty in current climate models. This interdisciplinary project will allow me the opportunity to exchange knowledge with experts in the fields of microbial community ecology and terrestrial ecosystem ecology at NIOO-KNAW. I will also foster an international collaborative network, which will benefit my host organisation and myself. The proposed fellowship will allow me re-enter the European academic system and develop the skills required to initiate my own effective research group following the project.

Keywords: microbial community ecology microbial biogeography,trait based approach,climate ecosystem carbon feedbacks,respiration
Plasma Jet Pack (PJP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling advances in space technology
Action type: Research and Innovation actions
Countries involved: Germany,Sweden,France,France,Czechia,United Kingdom
Call: SRC – In-Space electrical propulsion and station keeping (H2020-SPACE-2019, 2019)
Start date: 2020-01-01
End date: 2023-04-30
Duration (months): 40.0
Total project cost (EUR): 1642146.25
EU funding (EUR): 1640646.25
Participants: 8
Project status: SIGNED

This project proposes to develop a new electric propulsion module technology. This technology is based on the vacuum arc physic. This concept presents the advantage to store propellant into solid metal. This storage solution allows to largely reduce the complexity of propulsion module and operations (on-ground and in-orbit) constraints. The removal of in-orbit constraints (small impulse bit, no preheating, large total impulse) will pave the way to new propulsion module applications, in addition to the classical ones, and consequently to new satellite missions such as in-flight formation, electric propulsion pointing, continuous accurate altitude control. The consortium aims at achieving the validation of this propulsion module technology in 3 years (QR level). The team consists in experts from space propulsion, space hardware development and vacuum arc physics. During this project, it is planned to develop and validate building blocks for a family of 3 products which will have increasing performances in thrust, total impulse and specific impulse : • Plasma Jet Pack 0-30W • Plasma Jet Pack 0-80W • Plasma Jet Pack 0-150W After requirements and potential impact analysis, the first part of the project will be dedicated to building blocks development and qualification : Arc Discharge Chamber (ADC), Plasma Generator Unit (PGU), Power Propulsion Supply and Control Unit (PPSCU). A second part of the project will be focus on the PJP0-30 with a full development through an Electrical Model and a Qualification Model. This development will largely rely on technology building blocks. The qualification model will be tested in order to be ready to start the commercialisation phase at the beginning of 2023. Moreover a validation flight is planned during this project at the mid of 2021.

Keywords: vacuum arc thruster,satellites constellation,metallic propellant,arc discharge chamber,plasma generator unit,power propulsion supply and control unit,electrical model,qualification model
Next generation framework for global glacier forecasting (FRAGILE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1499950.0
EU funding (EUR): 1499950.0
Participants: 1
Project status: SIGNED

Worldwide glacier retreat outside the two large ice sheets is increasingly tangible and the associated ice-loss has dominated the cryospheric contribution to sea-level change for many decades. This retreat has also become symbolic for the effects of the generally warming climate. Despite the anticipated importance for future sea-level rise, continuing glacier retreat will affect seasonal freshwater availability and might add to regional water-stress in this century. Here, I envision a novel self-consistent, ice-dynamic forecasting framework for global glacier evolution that will lift the confidence in forward projections for this century to new heights. For the first time, each glacier on Earth will be treated as a three-dimension body within its surrounding topography without using any form of geometric simplification. The heart of the framework is the systematic utilisation of the rapidly growing body of information from satellite remote sensing. For this purpose, I intend to pass on to ensemble assimilation techniques that transiently consider measurements as they become available. This will streamline and increase the total information flow into glacier models. In terms of climatic forcing, global products will be replaced by regional forecasts with high-resolution climate models. Moreover, a more realistic representation of the local energy balance at the glacier surface is pursued that ensures multi-decadal stability in the melt formulation. The envisaged 3D finite-element modelling framework also allows a direct integration of iceberg calving, which is, on global scales, an often-unconsidered dynamic ice-loss term. To this day, a key limitation of glacier projections is the poorly constrained ice volume and its distribution at present. Here, I put forward a promising remedy that builds on multi-temporal satellite information to calibrate a state-of-the-art reconstruction approach for mapping basin-wide ice thickness on virtually any glacier.

Keywords: glacier,modelling,ice dynamics,data assimilation,global