Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
childrEn and Adults heaRing in noise: individual Differences in the Neurophysiology of Audition (EAR-DNA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Over 5% of the world population suffers from at least a moderate hearing loss (thresholds between 40-70 dB), which has pervasive effects on children’s academic performance or working adults’ professional life. Despite recent progress in hearing aid devices restoring speech intelligibility in quiet, understanding speech in noise remains a challenge for hearing-impaired (HI) individuals. Therefore, the present project aims to improve speech perception in noise in HI listeners by paving the way towards the development of neuro-steered hearing aids. To do so, we will use electroencephalography to investigate the neural correlates of three key factors underlying speech perception in noise: stream segregation, auditory attention and listening effort. They will be approached by means of neural entrainment, neural gain, and alpha oscillations, respectively. Although it is technically possible to simultaneously record the three measures, which would provide a comprehensive view on the neural processes underlying HI listeners’ difficulties in noise, it has not been done so far. Here, we will (i) first evaluate the effect of mild to moderate hearing impairment on stream segregation, auditory attention and listening effort in HI and normally-hearing (NH) young adults. Because hearing loss affects the development of auditory processing throughout childhood, this project will also aim to (ii) determine how neural processing of speech in noise develop in HI children. Last, based on the findings from (i) adults’ processing of speech in noise, we will explore the possibility to use neurofeedback (iii) to improve NH and HI listeners’ perception of speech in noise. The proposed project uses an innovative multidisciplinary perspective to tackle a remaining challenge in the field of auditory cognitive neuroscience. It will have significant impacts on general health (i.e. auditory rehabilitation) and language education (i.e. speech perception in noise in children).

Keywords: neurophysiology,hearing loss,developmental science
Twinning coordination action for spreading excellence in Aerial Robotics (AeRoTwin)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Spain,Croatia,United Kingdom
Call: Twinning (H2020-WIDESPREAD-05-2017-Twinning, 2017)
Start date: 2018-09-01
End date: 2022-02-28
Duration (months): 42.0
Total project cost (EUR): 997897.5
EU funding (EUR): 997897.5
Participants: 5
Project status: CLOSED

AeRoTwin is twinning coordination action for spreading excellence in Aerial Robotics. The overall goal of AeRoTwin is to decrease networking gaps and deficiencies between UNIZG-FER and internationally leading counterparts in EU, by significantly enhancing S&T capacity of the Laboratory for Robotics and Intelligent Control Systems (LARICS) at UNIZG-FER. The project objectives are i) increase UNIZG-FER research excellence and innovation capacity in the field of aerial robotics, in the following Strategic Research Domains (SRDs): SRD1) cooperative robotic missions, SRD2) aerial robot navigation, and SRD3) aerial robot configurability by S&T knowledge transfer that will implement expert visits, short-term visits, joint summer schools and co-supervising PhD students and by hands-on experience that will implement on-site trainings, ii) enhance UNIZG-FER networking capacity and scientific visibility by strengthening links to aerial robotics research community by conference attendance, special sessions organization, workshops and tutorials attendance, participation in joint EU and international projects and publication of joint journal papers and by dissemination and outreach activities planned for a general public and school students, and iii) improve UNIZG-FER quality of innovation management and technology transfer, by strengthening links to aerial robotics industry by participation at industry fairs and by collaboration agreements with businesses, by strengthening links to aerial robotics end users by implementation of end-user oriented workshops, and by innovation management knowledge transfer by organization of innovation management trainings and technology transfer workshops. AeRoTwin will create the basis for a common framework for aerial robotics community involving EU and international leaders of the field. The activities of the project will contribute to the consolidation of the community and will create the assets to go beyond the end of the 3-year twinning.

Keywords: aerial robotics,cooperative robotic missions,aerial robot navigation,aerial robot configurability
Engineering T cells and B cells for Immunotherapy using V(D)J recombination (VDJtargeting)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Israel
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-10-01
End date: 2022-09-30
Duration (months): 60.0
Total project cost (EUR): 1496875.0
EU funding (EUR): 1496875.0
Participants: 1
Project status: CLOSED

T cell engineering has shown clinical success mainly in haematological cancers, but scaling up is challenging due to reliance on ex vivo manipulations. In addition, B cell engineering has not shown therapeutic efficacy to date. Here, we propose a novel immunotherapy approach, allowing safe and efficient engineering of B cells and T cells, both ex vivo and in vivo. We will use adeno associated vectors (AAV) to integrate chimeric antigen receptor (CAR) or T cell receptor (TCR) genes into loci coding TCR chains and to integrate antibody (Ab) genes into loci coding Ab chains. Previously, we used AAV facilitated gene targeting in vivo to ameliorate genetic diseases in mice. For lymphocytes we develop “VDJ targeting”: A promoterless receptor/Ab gene flanked by recognition signal sequences (RSS) will be inserted into the endogenous locus by the recombination activating gene (RAG) complex during V(D)J recombination. Only developing lymphocytes, expressing RAG, will incorporate the receptor/Ab gene, which will thus be expressed in potent naïve cells from the strong endogenous promoter. Targeted developing cells are subjected to negative selection, thus reducing risk of adverse autoimmunity. Lack of promoter reduces spurious expression and oncogenic risk upon rare off-target integration. Targeting endogenous loci may allow allelic exclusion. In B cells it may allow utilizing the endogenous constant region to express a B cell receptor and, upon activation, a secreted Ab. Activation may be accompanied by proliferation and affinity maturation, including somatic hypermutation and class switching, to allow a potent immune response, memory retention and diminished antigenic escape. Where controlled autoimmunity is desired, we will engineer B cells to inducibly secret an auto-Ab. We will demonstrate efficacy in cancer and autoimmune disease models implanted with lymphocytes that we engineered while ex vivo differentiated and in mice injected with vectors for in vivo VDJ targeting.

Keywords: gene therapy,immunotherapy,gene editing,cancer,autoimmune
Targeting Purinergic Pathway in drug-resistant epilepsy using human Neurons and Glia. (TaPPiNG-EPI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 196590.72
EU funding (EUR): 196590.72
Participants: 1
Project status: CLOSED

Epilepsy is a neurological disorder characterized by recurrent seizures affecting 65 million people worldwide of which 6 million live in Europe alone with around 30% of patients not responding to currently available treatment. The ATP-gated P2X7 receptor (P2X7R) has recently emerged as a promising target for epilepsy, showing anticonvulsant and disease-modifying properties in animal models. However, to develop P2X7R-based therapeutics the cell types involved in pathological P2X7R activation must be determined, and whether results from rodent models can be replicated in human tissue must be tested. Using human induced pluripotent stem cell-derived neurons and glia and resected brain tissue from epileptic patients, TaPPiNG-EPI proposes to investigate the cell-specific alterations and pathological contribution in the P2X7R pathway and pharmacological targeting of hyperexcitability using P2X7R antagonists. These studies will be complemented by the investigation on the alterations in P2X7R pathway in GFP-P2X7 reporter mice available in the host institution (RCSI). Through international secondments and intersectoral collaborations TaPPiNG-EPI brings together experts in purinergic signalling, industrial partners, epilepsy clinicians as well as leading European academic labs with diverse expertise. The interdisciplinary and intersectoral components of TaPPiNG-EPI combined with international collaborations and secondments in academia, the excellent training record of the supervisor and RCSI and the outstanding resources for learning and development available at RCSI will give me the tools necessary to achieve research independence and my transition to a highly employable future neuroscientist with a focus on epilepsy.

Keywords: p2x7 receptors,epilepsy,ipsc derived neurons and glia,electrophysiology,pharmacology
All-Atlantic R&I for a Sustainable Ocean: High-level & Stakeholders Conference (All-Atlantic2021)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: Coordination and support actions
Countries involved: Portugal,Portugal,Portugal
Call: Conference on Marine Resources under the Portuguese Presidency (H2020-SC2-IBA-ALLATLANTIC-2020, 2020)
Start date: 2021-01-01
End date: 2021-09-30
Duration (months): 9.0
Total project cost (EUR): 216511.25
EU funding (EUR): 100000.0
Participants: 4
Project status: CLOSED

With Portugal holding the Presidency of the EU Council during the first semester of 2021, it provides an excellent opportunity to strengthen and promote the main EC priorities, including the European Green Deal and A Europe fit for the digital age. The "All-Atlantic R&I for a Sustainable Ocean: High-level & Stakeholders Conference" contributes to the implementation of these priorities based on strengthening R&I Cooperation across and along the Atlantic Ocean, from “pole to pole”. This conference will bring together high-level representatives and marine R&I stakeholders, from along and across the Atlantic Ocean, in a dialogue that will contribute to enhancing the science diplomacy efforts that began in 2011 at the European level, with the launching of the Atlantic Strategy and its 1st. Action Plan (2013) and the signing of the Galway and Belém Statements (respectively in 2013 and 2017). The event will be a step forward in the All-Atlantic Cooperation; it will be the opportunity to discuss the progress made so far, endorse a vision for the next years and launch a Pledging Platform as a new approach to the existing cooperation. This Platform will provide an understanding of the Atlantic marine R&I cooperation, enhancing stakeholder participation to co-design future actions and to monitor the progress enlarging the cooperative efforts. Discussions on the need for upscaled cooperation and new methodologies for ocean observation linked to digitalization processes represent an important innovative look forward to the integration of the Ocean-Space-Climate Nexus contributing to the topic of Ocean Sustainability. The conference’s Ministerial dimension linked to the stakeholders dynamic participation and side events will ensure the adequate involvement of the “All-Atlantic'' States and players and contributing to taking this All-Atlantic R&I Cooperation by two main legacy outputs, the Azores PPEU Conference Declaration and the All-Atlantic Pledging Platform.

Keywords: all atlantic ocean research alliance,galway statement,bel m statement,atlantic cooperation,marine resources,ocean observation,digital ocean,sustainable solutions,green deal,science diplomacy
Geographies of asylum justice: the lived realities and spaces of the Danish asylum procedure (JustAsylum)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

This proposed research examines the ways in which Western states’ receding commitment to refugee protection is re-shaping the current asylum system. As a result of ongoing global refugee crises, the institution of asylum is coming under great pressure. Countries across the world are growing increasingly reluctant to provide asylum to people in need. While asylum remains in force in national and international laws, it is being subverted in practice through a complex web of border enforcement and bureaucratic interventions. By analysing the lived realities of the asylum procedure, this research project will assess how these changes materialize and shape the provision of asylum as a legal right. More specifically, this research will develop a feminist geographical approach in order to trace the ways that this legal process of deciding who obtains asylum is carried out in practice and experienced by the actors involved. To do this, the researcher – Dr Malene H. Jacobsen – will relocate from Ireland to Newcastle University in the United Kingdom in order to undertake an in-depth qualitative study of the asylum procedure in Denmark, a country that has long been at the forefront of reducing the EU’s commitment to asylum and refugee protection. This research project will significantly advance scholarship on asylum determination, refugee protection, and processes of juridical border work, contributing to the fields of political geography and legal geography as well as broader interdisciplinary debates across border studies, refugee studies, and socio-legal studies. Findings from this research will further inform European public and policy debates about asylum through engagement with key stakeholders and targeted audiences. Dr Jacobsen will gain research expertise in social geography, feminist theory, and creative qualitative methodologies, and expand her European networks among scholars, policy communities, and the nongovernmental sector.

Keywords: space,borders,feminist geopolitics,asylum determination,social justice,intersectionality,identity,denmark
Enhancing INNovation management capacity of CATalan small and medium enterprises (INNCAT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-07-01
End date: 2014-12-31
Duration (months): 6.0
Total project cost (EUR): 80500.0
EU funding (EUR): 64400.0
Participants: 1
Project status: CLOSED

Horizon 2020 call “Enhancing the innovation management of SMEs” proposes the offering of mentoring and coaching services to SMEs with the objective of increasing and accelerating the economic returns from innovation. The current proposal describes in detail the services focused on enhancing innovation management capacities of SMEs and proves ACCIÓ’s capacity to successfully deliver such services. The service will be provided to two specific groups of companies: beneficiaries of the SME instrument and, SMEs with significant innovation activities and a high potential for internationalisation. The minimum number of 7-day packages to be delivered are 20, although depending on the number of beneficiaries of the SME instrument up to 32 7-day packages could be developed. As coordinator of the Catalan node of the Enterprise Europe Network, ACCIÓ offers a wide range of innovation services to SMEs. ACCIÓ is specialised in promoting innovation and internationalisation among SMEs and has implemented several successful programmes over the last 20 years. In 2013 ACCIÓ's innovation advisors visited 100 SMEs for the first time, managed more than 4.000 expression of interest for technology transfer or partner search and reached more than 3.000 people through its monthly newsletter “EU R&D&I opportunities”. The proposed INNCAT team is fully committed in the delivery of the project, is trained in IMP3rove methodology and have a broad and extensive expertise in innovation and business support and management.

Keywords: sme instrument,innovation management,smes enterprise europe network,innovation capacity,key account management,horizon 2020,assessing innovation,imp3ove,business
Advertisement displays manufactured by hybrid in-mould integration (Optintegral)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: A new generation of components and systems: Engineering of advanced embedded and energy and resource efficient components and systems
Action type: Innovation actions
Countries involved: Spain,Spain,Bulgaria,Finland,Finland,Hungary,United Kingdom
Call: Advanced Thin, Organic and Large Area Electronics (TOLAE) technologies (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 5997562.5
EU funding (EUR): 5132737.5
Participants: 11
Project status: CLOSED

OptIntegral develops and demonstrates LED displays for advertisement manufactured by in-mould hybrid integration of TOLAE electronics and photonics components. The aim is to proof the flexibility and sustainability of the novel manufacturing process enabling a diversity of LED display products competitive with EU-labour cost. Three different large area displays: 3D glasses free, lightpipe and backlight, will be demonstrated by three SMEs. The novel manufacturing process combines Roll-to-Sheet and Roll-to-Roll of flexible electronics with In-mould hybrid integration of the optoelectronics with the optics. The novel displays harvest the intrinsic TOLAE benefits with thin, light weight, and bendable structures; and the specific in-mould integration benefits of a) automating the current manual assembly with high reproducibility and yield and b) enabling new optical design concepts that bring better display resolution, lower costs and energy savings. This differential value supports the effective market introduction of TOLAE based highly competitive products. OptIntegral enables a wide choice of materials and options in process design to put the technological advances at the service of the cost, performance and time-to-market requirements of the novel displays. The workplan sets and consolidates the value chain by the demonstration platform that links all actors, from LED suppliers to displays users. This allows to respond to market demands and to capture the user feedback on the effectiveness of the displays to communicate information and to meta-communicate attitudes towards the advertiser brand. Three display manufacturers that are currently manufacturing and selling LED displays in EU will enlarge their portfolio by setting up pilot manufacturing lines and co-developing demonstrators adapted to their customers’ needs. This is achieved during the project with the goal to be on the market 1 year after the end of the project as a result of OptIntegral business case.

Keywords: flexible electronics,injection moulding,plastic optics,display,advertisement
Light Night (Light Night)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: United Kingdom
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2015-04-01
End date: 2015-10-31
Duration (months): 7.0
Total project cost (EUR): 84410.0
EU funding (EUR): 84407.0
Participants: 3
Project status: CLOSED

The 20th Century was characterised by a tremendous growth in our capability to develop ever more sophisticated electronic devices, which have fundamentally transformed the way society functions. We now sit on the threshold of a similar revolution due to developments in photonics, which seeks to exploit the photon – the elementary particle of light – in the same way that electronics is ultimately concerned with controlling the electron. Photonics has been identified as a “Key Enabling Technology” by the European Commission. Within Europe there are over 5,000 photonics based small companies and the sector employs nearly 300,000 people. In addition to forming the backbone of the Internet, the technology is already starting to revolutionise manufacturing, healthcare, lighting, displays and sensing. This proposed Researcher Night – Light Night - will coincide with the UNESCO Year of Light 2015, it will bring together the Aston Institute of Photonics Technology (AIPT), Aston University, with the Library of Birmingham and Community Arts Group, the Flatpack Film Festival, to deliver an afternoon and evening of public engaging content, informed by EC funded research, to raise the enormous importance of photonics research to local schools, community groups and library visitors. Light Night is designed to engage adults and young people in a programme which enables them to identify the importance of light to their lives, and experiment in light based activities. The Night will end with a performance by international sound electronic music artist Pantha du Prince, who will perform his most recent album Elements of Light at the Birmingham Symphony Hall.

Keywords: photonics,public engagement,research