Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Evolutionary history and ecological adaptations of ammonia oxidizing Thaumarchaeota. (THAUMECOPHYL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 178156.8
EU funding (EUR): 178156.8
Participants: 1
Project status: CLOSED

Ammonia oxidizing archaea (AOA), a clade of the Thaumarchaeota phylum, diversified in a variety of marine and terrestrial environments. Due to their abundance, AOA are deemed major players in the global cycle of nitrogen. They also produce greenhouse gasses. Despite their ecological importance, the nature and origin of ammonia oxidizing metabolism and the reasons for the ecological success of AOA are still unknown. This project aims at performing the first comprehensive evolutionary and comparative genomic analysis of Thaumarchaeota to identify crucial metabolic and genomic features. Prof. Schleper is a leading scientist in Thaumarchaeota cultivation, genomics and physiology. Metagenomic data produced in her laboratory give now access to genomes of crucial taxa for this project. I will complete these genomes, and analyse all available AOA genomes with a sophisticated model of genome evolution to reconstruct the species tree of Thaumarchaeota and the events (gene duplications, transfers and losses) that occurred along their evolution. The genome of the AOA’s ancestor will be inferred, and the minimal gene set required for ammonia oxidation identified. The sets of evolutionary events and the ancestral genome will be linked to metabolic and ecological transitions to obtain the scenario of ammonia oxidation emergence and of the adaptation of AOA to various environments, thus addressing key questions in the fields of ecology, evolution, and archaea biology. This interdisciplinary project is only possible through the unique combination of my expertise in comparative genomics and molecular phylogeny with the expertise of Prof. Schleper's group, which will result in two-ways transfers of knowledge and skills. Beyond scientific training, I will be trained to project management and project design with experimental biologists. This is crucial for my career, as I plan to start a group at the edge of bioinformatics and experimental biology to study how complex systems evolve.

Keywords: archaea,genome evolution,ecological adaptation,phylogenomics,metagenomics,genome assembly,ammonia oxidation,nitrification,nitrogen cycle
Novel Bone Regeneration Drug Osteogrow: Therapeutic Solution for Lumbar Back Pain (OSTEOproSPINE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Austria,Austria,Austria,Austria,Germany,Croatia,Croatia,Croatia,Poland,Slovenia,United Kingdom
Call: Clinical research on regenerative medicine (H2020-SC1-2017-Single-Stage-RTD, 2017)
Start date: 2018-01-01
End date: 2023-06-30
Duration (months): 66.0
Total project cost (EUR): 6004152.5
EU funding (EUR): 6004152.5
Participants: 15
Project status: SIGNED

We propose a clinical program for the evaluation of a novel bone-regeneration product OSTEOproSPINE as a treatment for intractable chronic back pain. OSTEOproSPINE is a novel bone regeneration therapy composed of OSTEOGROW (recombinant human bone morphogenetic protein 6 [rhBMP6] delivered in autologous peripheral blood coagulum) reinforced with allograft (a compression resistant matrix). OSTEOproSPINE is designed to guide the formation of new bone at extra-skeletal site and replace autograft harvested from patient’s iliac crest for the fusion of lumbar vertebrae. By generating new bone, OSTEOproSPINE will restore the spine’s weight bearing function, reduce the severity of back pain and improve the success rate of posterolateral spinal fusion surgery. The program consortium of 12 partners from 5 EU member states has been assembled to conduct a Phase II, randomized, patient- and evaluator-blinded clinical trial of OSTEOproSPINE. Four clinical centers will enroll 143 patients suffering from degenerative disc disease to assess OSTEOproSPINE efficacy and safety in comparison with Standard of care (autograft) and Osteogrow. The Ethics Committee of the leading clinical site in Vienna has already granted a conditional approval for this trial. As the coordinating institution of the FP7 HEALTH project Osteogrow (Grant No. 279239), we have evaluated Osteogrow in Phase I/II clinical trials for distal radius fracture and high tibial osteotomy. Osteogrow exhibited excellent safety profile in these trials, supporting OSTEOproSPINE safety for administration in humans. A positive outcome of proposed trial will confirm OSTEOproSPINE potential to form a functioning new bone in human and by this restore the spine’s function and improve the quality of life in patients with degenerative disc disorders using the ground principle of regenerative medicine: “provide the correct molecular signals to a population of presumptive cells in a permissive microenvironment”.

Keywords: degenerative spinal diseases,degenerative disc disease,spinal fusion,recombinant protein as regenerative therapy,phase ii clinical trial
Neuroimmune activation as a novel therapeutic approach for IBD (NeurIMM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Portugal
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-09-01
End date: 2019-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

NeurIMM has been designed to investigate the commercial and technical viability of a novel, targeted therapy for Inflammatory Bowel Disease (IBD), based on a recently uncovered signaling axis between intestinal type 3 innate lymphoid cells (ILC3s) and enteric glial cells. This discovery by the team of Prof. Henrique Veiga-Fernandes in the ERC CoG grant 647274 ‘GliaInnateSensing’ was recently published in Nature (Ibiza et al, Nature 2016). NeurIMM proposes the use of a glial cell-derived immunomodulator to restore intestinal homeostasis, by inducing a tissue protective immune response. Importantly, this novel therapy will also promote tissue healing to reverse immune-cell mediated tissue damage, leading to improved outcomes for the patient. This could have major implications for patients suffering from IBD. In addition, this approach also has potential as an effective therapy against cancer, (pediatric) gastroenteritis, and other inflammatory disorders.

Keywords: glial cells,ilc3,therapy,gdnf,mucosal healing,intestinal homeostasis
The Implications of Selective Information Sampling for Individual and Collective Judgments (InfoSampCollectJgmt)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-05-01
End date: 2024-04-30
Duration (months): 72.0
Total project cost (EUR): 1158625.0
EU funding (EUR): 1158625.0
Participants: 1
Project status: SIGNED

Much research has shown that judgments are the products of imperfect information processing heuristics. Recently, an alternative theoretical perspective has been proposed. It emphasizes that people form judgments by observing information samples about the alternatives. Sampling-based theories can explain numerous judgment patterns such as risk aversion, overconfidence, illusory correlations, the in-group out-group bias, or social influence. The sampling approach has illustrated how these and other important patterns of human judgments can be parsimoniously explained by assuming a common source of bias. But at least two important questions remain: 1. How do sampling explanations for judgment biases can be integrated with explanations that focus on information-processing biases in order to explain judgment patterns in naturally occurring environments? 2. What are the implications of selective information sampling for collective judgments and the distribution of beliefs and attitudes over social networks? I set to answer these pressing questions by (1) developing integrative belief formation models that incorporate both sampling-based mechanisms and information processing-based mechanisms; (2) collecting and analyzing experimental and field data to test these integrative models and uncover how the two classes of mechanisms interact; (3) building on these insights to develop models that lead to testable predictions about collective judgments and test these predictions with field and experimental data; (4) running experiments to measure the extent to which social network driven information sampling can contribute to opinion polarization. The project will carry novel prescriptions to limit judgment biases such as the prevalence of negative stereotypes about socially distant others or the resistance to institutional change. It will also carry prescriptions to limit the emergence of collective illusions, and contain the polarization of opinions across social groups.

Keywords: judgment,collective judgment,wisdom of the crowd,judgment aggregation,learning,attitudes,illusions
Redefining the Agency: Post-1989 Crises of Czech and Former East German Theatre (Theatre ReDefined)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2022-01-01
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

"Redefining the Agency: Post-1989 Crises of Czech and Former East German Theatre" will introduce an innovative historiographical and theoretical approach to examining the inter-relation between theatre and the society. The process of the redefinition of theatre’s function during transformations of social and political discourses will be investigated within a case study which will give the first comparison of Czech and the former East German theatre after 1989. The research will focus on the period of genuine societal transformation between 1990 and 1995 and will proceed along the intersection of theatre studies, media studies, and political history. Within the interdisciplinary research, the notion of agency will be brought into discussion to explore its potential for theatre studies. Therefore, "Redefining the Agency" will apply an innovative methodology combining discourse analysis with performance analysis. The 2-year-project will result in a monograph written in English, which will introduce the theoretical framework and method, as well as the findings of the research to the broadest international audiences.

Keywords: theatre,agency,the political,crisis,performance analysis,discourse analysis,history
Next REnewable multi-GENeration technology enabled by TWO-phase fluids machines (REGEN-BY-2)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Spain,Germany,Italy,Italy,Italy,Belgium,Greece,France,France,France
Call: Developing the next generation of renewable energy technologies (H2020-LC-SC3-2019-RES-TwoStages, 2019)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 5419327.5
EU funding (EUR): 4905748.75
Participants: 14
Project status: SUSPENDED

REGEN-BY-2 will research, design, construct and experiment a first-of-its-kind lab-scale prototype of a recent near-worldwide patented thermodynamic cycle and related plant for the conversion of thermal sources in energy vectors, i.e. electric, heating and-or cooling powers. The start-up TIFEO, which was founded in 2018 by the team leading this proposal and is the exclusive licensee of the patent driving REGEN-BY-2, is a potential European Unicorn. REGEN-BY-2 can convert (from small to large-scale) any typology of renewable thermal source from low to high-temperature (e.g. solar, aerothermal, geothermal, hydrothermal) including additional thermal sources (e.g. waste heat). REGEN-BY-2 is enabled by machines capable to work with two-phase fluids, i.e. constituted by both liquid and vapor phases. The patented thermodynamic cycle is highly efficient as it is constituted by a proper combination of Carnot cycles operating with two-phase fluid circulating in novel two-phase expanders and two-phase compressors. To be successful, these two-phase machines will have to be designed, prototyped and integrated in the REGEN-BY-2 lab-scale prototype. Moreover, the patented technology has large flexibility due to the control of many process parameters, allowing chasing and satisfying the end-users energy demands in a predictable and dispatchable way. By the exploitation of renewable thermal sources from small to large-scale, by converting them more efficiently and with more flexibility into electric, heating and-or cooling energy vectors, REGEN-BY-2 will induce greater demand for and increasing use of renewable thermal sources. REGEN-BY-2 is a breakthrough in our energy infrastructure as it can be used in wide energy sectors (e.g. District Heating&Cooling systems and Distributed Renewable Flexible Energy systems). The research is low-TRL and high risk. For this, a full value international chain is assembled (Universities, RTOs, SMEs, Large Enterprises, a Standards Organization).

Keywords: flexible multi generation,combined cooling heating and power,two phase fluid expanders,two phase fluid compressors,patent realization,high potential startup unicorn
Lightning protection of wind turbine blades with carbon fibre composite materials (SPARCARB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,United States,Denmark,United Kingdom,Denmark,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EID) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 1093151.52
EU funding (EUR): 1093151.52
Participants: 8
Project status: CLOSED

The consortium behind SPARCARB – Global Lightning Protection Services A/S (GLPS, non-academic beneficiary), Denmark, together with the University of Southampon (SOTON, academic beneficiary entitled to award doctoral degrees), UK, and six Partner organizations – aims at providing an innovative international, interdisciplinary and intersectoral training network for four Early-Stage Researcher (ESRs), which will integrate in a single project (1) Science-based Training in material and electrical engineering; (2) Transferable Skills-based Training in carbon fibre, wind turbines, lightning protection technologies, business and innovation, and other competences; (3) and Research-based Training designed around cutting-edge challenges for the Wind Power Industry, which has identified the need for continuous research on lightning protection of large wind turbines with blades incorporating CFC structural components. The SPARCARB project aims at addressing the strong lack of doctoral-level trained human resources to push forward the research base in the field of lightning protection of CFC structures, building the proper environment for shifting paradigms in the Wind Power Industry. Specifically, the project will address scientific and technological challenges related to an effective protection of CFC wind turbine blades from lightning-induced damages, enabling the reliable use of very large and more efficient wind turbines. The goal is to train four ESRs to be familiar with both Industry (15 months at GLPS and secondments to industrial partner organizations for 3 months) and Academia (18 months at SOTON The doctoral training programme will be carried out according to SOTON’s criteria from which all four ESRs will obtain doctoral degrees. The envisaged training will provide a range of skills to all ESRs making them high-potential candidates to be employed at GLPS and other wind power industry players.

Keywords: lightning protection,high voltage,carbon fibre composites,wind turbine blades
Consumer-oriented ICT Solutions for creative SMEs providing Art in Bespoke Fashion (iART)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Content technologies and information management: ICT for digital content, cultural and creative industries
Action type: Innovation actions
Countries involved: Ireland,Belgium,Poland,Netherlands
Call: Support the growth of ICT innovative Creative Industries SMEs (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2016-06-30
Duration (months): 18.0
Total project cost (EUR): 618129.21
EU funding (EUR): 491705.0
Participants: 5
Project status: CLOSED

The main objective of the iART project is to bring visual art into bespoke clothing so as to make apparel products more valuable compared to other garments in the market and to support artists to exploit their work. To reach this objective a set of innovative ICT solutions has to be developed first. This new approach will also change the business relationship along the conception and design phase in the clothing sector from B2B to B2C, where the artist and the consumer will connect through enabling platforms like iArt. iArt will be built upon an existing B2C webshop for bespoke shirts Bivolino.com. In particular, the specific ICT developments of the project are: 1. Upgrade the configuration toolkit from 2.5D to 2.5D/3D by including shadowing and rotating features without the need of plug-ins and ease the extension of the catalog to clothing accessories and nightwear fitting with the shirts. 2. Move to real-time online rendering (fabric draping), so as to speed up and increase the flexibility of the whole process from artist design over fabric creation to customized bespoke shirts and other garments (fabric rendering on 2.5D/3D clothing configurator). 3. Build a B2C platform enabling co-creation and user generated art content. Develop an Advanced Artist Interface (AAI) with artist cockpit. Implement an advanced user interface to allow easy 2.5D/3D viewing in many other platforms through open API. iART is expected to create extra revenues for Artist’s micro SMEs. The European Fashion and Clothing industry SMEs take up ICT enabling innovative supply-chains to generate more revenues through high-margin made-to-order collections which cannot be imported from mass production countries. Finally ICT providers are stimulated to offer innovative tools generating business and turnover. As this sustainable business model is supported by easily accessible advanced ICT tools (through open API’s) it will be replicable and so has the potential to create a wide impact.

Keywords: fashion,garments,artist,3 d configurator,3 d online visualisation,real time fabric rendering,advanced artist and user interface,coloured pattern placement,mobile solutions,fashion sme
Conquering Self-Representation: A Collaborative Approach to the Aesthetical-Political Dimension of Amazonian Contemporary Art (Amazonart)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

This project develops a novel theoretical and methodological approach to understand the work, trajectories and activism of indigenous Amazonian contemporary artists as they enter global art circuits and seeks to produce more suitable curatorial narratives. Over the last decade the field of contemporary art has expanded its boundaries through the integration of art practices from various parts of the globe including indigenous art. A significant scholarship has traced the practices and global articulations of Australian and North American indigenous artists, which have developed a strong circuit of art agents and stimulated readjustments in art historical narratives. Yet the global rise of other vibrant indigenous art practices requires immediate attention. This is the case of Amazonian contemporary art which is mobilising different aesthetics and agendas and proposing novel contributions to the arts and humanities at large. With a focus on Amazonian Peruvian artists, this project develops a novel approach to explore the work, trajectories and activism of indigenous Amazonian contemporary artists as they enter global art circuits. Its aim is to produce the first major study on Amazonian contemporary art that expands the current framework of analysis of art and shamanism to look at artists’ practices, agendas and mobility across the local, urban, national and global arenas and to propose more suitable vocabularies and curatorial narratives. It does this through an innovative collaborative methodology with Amazonian artists responding to their aim of self-representation. This MSCA action draws on my on-going collaborations with Amazonian artists and on my background in the fields of anthropology, museum studies and cultural policies. The participatory and interdisciplinary approach of this research seeks to contribute to dialogues amongst anthropology, art history and curatorial studies and benefit museum practices and policies in addressing indigenous art today.

Keywords: amazonian art,indigenous self representation,activism and mobility,anthropology of art,aesthetics and politics,collaborations,curatorial narratives,contemporary art,global art history