Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
FAST and efficient international disaster victim IDentification (FASTID)

Framework: FP7 — Cooperation
Programme: Security
Destination: Restoring security and safety in case of crisis
Action type: Collaborative project
Countries involved: France,Germany,United Kingdom,Germany,United Kingdom,Denmark
Call:  (FP7-SEC-2009-1, 2009)
Start date: 2010-04-01
End date: 2013-03-31
Duration (months): 36.0
Total project cost (EUR): 2990190.24
EU funding (EUR): 2270476.0
Participants: 6
Project status: CLOSED

An information management and decision support system for improved disaster victim identification (DVI) will be developed for crisis management. The system will speed up the correct identification of the injured and dead following disasters with multi-national victims Training methods for optimal DVI with the system will also be developed. The computer supported methodology will consist of a system to be used world wide which will provide automatic matching between missing persons and those discovered injured or dead. An expert will however still make the final confirmation given the seriousness of this task. The system and training methods will incorporate full consideration of different national, religious and cultural considerations of how to deal with the injured and dead as well as how best to name different identifiers used to match missing and found persons to optimise international cooperation. The system will support information sharing and cooperative planning across organisations and nations, also dynamically in an ongoing crisis. It will provide improvement with respect to performance, reliability, speed and cost. The project has been initiated by INTERPOL and the BKA (German Federal Criminal Police Office) after identifying PLASSDATA software as a good basis to start development. PLASSDATA will develop the core DVI system, two Fraunhofer Institutes and the University of Dundee will develop identification methods based on image retrieval and body modifications. Dundee will also lead the development of international operational commonality. Crabbe Consulting Ltd will support overall management and coordination. The results will be used by INTERPOL and as many of its 187 national member countries as possible. PLASSDATA foresees a return on its investment through the sales of DVI software and also products in other markets based on the knowledge it will develop in the project for the DVI system incl. Rich Internet Application (RIA) software.

Keywords: "information management and decision support","disaster victim identification","crisis management and cooperative planning" "crisis management and training"
Integrated System for Interoperable sensors & Information sources for Common abnormal vessel behaviour detection & Collaborative identification of threat (I2C)

Framework: FP7 — Cooperation
Programme: Security
Destination: Intelligent surveillance and enhancing border security
Action type: Collaborative project
Countries involved: France,France,Luxembourg,Norway,France,France,France,European organisations area,Finland,Belgium,Germany,Spain,Belgium
Call:  (FP7-SEC-2009-1, 2009)
Start date: 2010-10-01
End date: 2014-09-30
Duration (months): 48.0
Total project cost (EUR): 15962707.2
EU funding (EUR): 9869621.55
Participants: 20
Project status: CLOSED

The I2C integration project proposes for 2015 a new generation of innovative sea border surveillance system implementing key existing and in development capacities to track all vessel movements to early identify and report on threats associated to detected suspicious events. These key capacities are: *Shore based sensors platform grouping new sensor technologies; long range HFSW radar, FMCW radar to track small crafts (both prototypes are in experimentations), AIS stations and conventional coastal radar. This platform performs permanent all weather traffic surveillance over wide maritime zone up to 200 nautical miles. *Deployable sensors platforms to perform local node observation campaigns to complete shore based surveillance. Four equipped platforms are deployed; aircraft and vessel patrols, USV and Zeppelin, which offers absolute quiet flight with no vibration for high resolution observation quality and a payload of 2 tons for sensors and communication devices. *Capacity for common operational traffic picture to correlate vessels tracks from shore based and deployable sensors plots. *Capacity for common intelligent operational traffic picture appending to vessel tracks information on performed activities, flags, sea state conditions, regulations, etc. *Capacity to detect abnormal vessel behaviours and issue automatically alarms to operator for validation. Detection is based on multi-parameters rules and detection engines. *Capacity to understand suspicious event, early identify threat and issue periodically interpretation files to authorities for decision. *Capacity to transfer useful data sets through communication network based on Distributed Systems intercommunication Protocol (DSiP) and VSAT/Digital Video Broadcast technologies. The consortium is restricted to the only partners owning above capacities and an European User&amp;Steering Committee is maintained during the I2C project lifetime to express user needs to be verified in the 1.5 year system exploitation.

Keywords: system for intelligent sea border traffic picture up to identify threats from suspicious vessels
Selective Antibodies Limited Immuno Assay Novel Technology (SALIANT)

Framework: FP7 — Cooperation
Programme: Security
Destination: Increasing the Security of citizens
Action type: Collaborative project
Countries involved: United Kingdom,France,Ireland,Slovakia,Netherlands,Netherlands,United Kingdom,Finland,Netherlands
Call:  (FP7-SEC-2009-1, 2009)
Start date: 2010-09-01
End date: 2013-12-31
Duration (months): 40.0
Total project cost (EUR): 4472718.11
EU funding (EUR): 3362598.6
Participants: 11
Project status: CLOSED

SALIANT aims to develop a hand-held device for real-time analysis of trace levels of explosives, chemicals and drugs. The key innovation is a positive detection lateral-flow test for small molecules that is highly sensitive and simple to use making it ideally suited to deployment by First Responders at crime scenes and terrorist incidents. Lateral flow immunodiagnostics has long offered the promise of fast, high quality testing for substances of low molecular weight. There have however been very real challenges to bringing the full power of such technology to bear in this area. The problem is simply size. Large analytes can support the simultaneous binding of both capture and detector antibodies, allowing typical excess-reagent sandwich immunoassays to be formatted in which increasing analyte concentration provides an increase of observable signal over a very low zero background. Small molecules are simply not large enough to support such simultaneous binding. Alternative systems in effect measure how much analyte is not present. This causes major problems in terms of precision, sensitivity and read-out where, classically, increasing concentration of analyte reduces the signal produced, making point-of-need devices often difficult to read. What is required is a robust system in which there is no observable signal in the absence of analyte, and even low level samples give an obvious observable signal over this zero background. SALIANT offers a system based on a small bindable moiety that is first conjugated close to the binding site of a primary antibody against the analyte such that when analyte binds the antibody, the moiety can still be bound by a labelled secondary antibody. A large reagent-analogue of the analyte is also introduced, binding analyte-unbound primary antibody, and thereby blocking binding of the secondary antibody to the moiety. Thus the more analyte present, the more binding of secondary antibody occurs and the more signal is produced.

Keywords: detection,forensic,explosives
CRitical Incident management training System using an Interactive Simulation environment (CRISIS)

Framework: FP7 — Cooperation
Programme: Security
Destination: Restoring security and safety in case of crisis
Action type: Collaborative project
Countries involved: United Kingdom,Netherlands,United Kingdom,Belgium,Sweden,Iceland,Portugal,Netherlands,United Kingdom,Denmark
Call:  (FP7-SEC-2009-1, 2009)
Start date: 2010-05-01
End date: 2013-10-31
Duration (months): 42.0
Total project cost (EUR): 4590310.18
EU funding (EUR): 3495612.0
Participants: 13
Project status: CLOSED

CRISIS is a 42 month project to research and develop an advanced critical incident management, interactive simulation environment for training security and emergency personnel in airport operational security. The prototype to be delivered will be distributed, scalable, collaborative interactive simulation environment that will enable training of crisis managers and their staff at airports, at different levels of the organization. The prototype system will avoid the simulation paradigm where the trainee selects one of a number of pre-set drill oriented choices at a predictable decision point. Instead, using an interactive games paradigm, the trainees will be able to practice situation and cue assessment, problem diagnosis, decision making and action coordination, in real-time in response to a critical incident. Currently, one key problem hindering the maintenance of a high level of preparedness in operational security organizations at airports is the long 2-year wait between major exercises. In CRISIS, we will enable organizations and individuals to train-on-demand, and as frequently as needed due to the innovations, such as end-user re-configurability of training scenarios. This will allow staff to train individually &apos;playing&apos; against the system, as a team within an organization, across organizations, and at different levels of the command hierarchy. CRISIS will adopt a 3-stage development strategy, integrating, testing and iteratively evaluating user performance at each step of the way. The CRISIS consortium brings together a powerful combination of expertise in User modeling and requirements engineering, Games and simulation, Software engineering, distributed systems, and security, Decision sciences and technology, User performance evaluation, to deliver capability for training and improving operational security preparedness at airports.

Keywords: incident management training,crisis management
RESILIENT INFRASTRUCTURE AND BUILDING SECURITY (RIBS)

Framework: FP7 — Cooperation
Programme: Security
Destination: Increasing the Security of infrastructures and utilities
Action type: Collaborative project
Countries involved: United Kingdom,Israel,Sweden,Denmark,Greece
Call:  (FP7-SEC-2009-1, 2009)
Start date: 2010-11-01
End date: 2013-10-31
Duration (months): 36.0
Total project cost (EUR): 4406966.8
EU funding (EUR): 3321957.8
Participants: 7
Project status: CLOSED

The RIBS-project supports the design of effective and viable integrated security measures aimed at protecting infrastructures without impacting on their business dynamics. In a global context where national interests are increasingly interrelated, the most vulnerable infrastructures in Europe, and particularly the most critical ones, are primary targets for terrorists. Attacks, carried out under a national, political, or religious banner, now strike regularly in our cities, causing deaths, damage and disruption on an unprecedented scale. In the past seven years alone, 1300 terrorist incidents have taken place on European soil. The RIBS project will deliver more effective and viable security measures by supporting a design process that integrates a broader understanding of the environment (and the contextual factors such as human elements) within which these measures are meant to be implemented. The particular objectives of the project include: • a set of functional and non-functional requirements that will drive an effective security system design process. • a set of protection measurement techniques that can be used to assess the level of protection offered by candidate security products proposed to be implemented in buildings and infrastructures. This work will be carried out for a range of security systems aimed at securing buildings against hostile reconnaissance, intruders and hazardous attack (including chemical, biological and explosive). The RIBS-project will derive a scientific method for security system engineering design that can be challenged and improved over the years, similarly to other areas of engineering and physical sciences. • Phase 1: Study of a &apos;live&apos; building and its ‘eco-system’, its protection measures, and threats; and integration of these elements into a single multi-layer model. • Phase 2: Identification of vulnerabilities through incident analysis and protection-measures analysis. • Phase 3: Development of design requirements.

Keywords: risk assessment threats integrated security system infrastructure cbrn intruder protection measures
Microfabrication-Based Rational Design of Transcriptional-Metabolic Intervention for the Treatment of Hepatitis C Virus (HCV) Infection (TMIHCV)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Applied life sciences and biotechnology
Countries involved: Israel
Call:  (ERC-2009-StG, 2009)
Start date: 2010-04-01
End date: 2015-03-31
Duration (months): 60.0
Total project cost (EUR): 1994395.0
EU funding (EUR): 1994395.0
Participants: 1
Project status: CLOSED

Hepatitis C Virus (HCV) infection affects over 3% of the world population and is the leading cause of chronic liver disease worldwide. Current treatments are effective in only 50% of the cases and associated with significant side effects. Therefore, there is a pressing need for the development of alternative treatments. Recently, our group and others demonstrated that the HCV lifecycle is critically dependent on host lipid metabolism. In this context, we demonstrated that the grapefruit flavonoid naringenin blocks HCV production through PPAR± and LXR±, transcriptional regulators of hepatic lipid metabolism. While these results are promising, our ability to rationally control metabolic pathways in infected cells is limited due to an incomplete understanding of the regulation of hepatic metabolism by its underlying transcriptional network. This project aims to develop a comprehensive model of hepatic metabolism by integrating metabolic fluxes with transcriptional regulation enabling the rational design of transcriptional-interventions which will minimize HCV replication and release. Our approach is to develop two microfabricated platforms that will enable high-throughput data acquisition and a human-relevant screening. One component is the Transcriptional Activity Array (TAA), a microdevice for the high-throughput temporal acquisition of transcriptional activity data. The second is the Portal Circulation Platform (PCP) which integrates intestinal absorption module with a liver metabolism compartment enabling the high-throughput human-relevant screening of treatments as a substitute to animal experiments. This work will lead to the development of novel drug combinations for the treatment of HCV infection and impact the treatment of diabetes, obesity, and dyslipidemia.

Keywords: tissue engineering,hepatitis c virus,liver,microfabrication
Travels of the Mind: Modes of brain functioning in complex dynamic environments (MINDTRAVEL)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: Italy
Call:  (ERC-2009-StG, 2009)
Start date: 2010-07-01
End date: 2015-06-30
Duration (months): 60.0
Total project cost (EUR): 1219597.0
EU funding (EUR): 1219597.0
Participants: 1
Project status: CLOSED

Subjective everyday experience entails a well-structured and continuous flow of sensory signals, actions, thoughts and emotions. How does the brain build such a coherent representation of space and time despite the vast amount and confusing nature of the input? Furthermore, what are the physiological constraints preventing simultaneous awareness of multiple spatial and temporal instances? Here I propose a novel approach (&quot;brain modes&quot;) to investigate these issues within life-like experimental settings. I will investigate how the brain selects and integrates relevant information using complex dynamic environments that includes space, time and multisensorial inputs. Combining model-free and model-driven analyses of functional imaging data I will examine: 1. How signals in different sensory modalities and same/different locations interact in complex environments; 2. How contextual information influences memory encoding and retrieval and the ability to integrate current sensory signals with events in the past. 3. How prospective goals and expectancies arising from the temporal dynamic of the context influence on-line processing. My expectation is that the results will reveal novel mechanisms underlying the ability to organise information in an orderly manner, on a time-line spanning the past, the present and the future; and how we can direct our thoughts along this time-line. My investigation will provide new evidence on the capacity limitations of this selection process and how integration and competition interact to form a representation of the external world that evolves as a coherent flow through space and time. Potential practical implications are foreseen for the design of brain-machine interfaces and for understanding the abnormal perceptions of mental illness.

Keywords: space,time,multisensory,attention,fmri
Regulatory Genomics in Drosophila (REGULATORY GENOMICS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Genetics,Genomics,Bioinformatics and Systems Biology
Countries involved: Austria
Call:  (ERC-2009-StG, 2009)
Start date: 2010-04-01
End date: 2015-03-31
Duration (months): 60.0
Total project cost (EUR): 1794400.0
EU funding (EUR): 1794400.0
Participants: 1
Project status: CLOSED

A major goal of biology is to explain how gene regulatory information is encoded by the genome. To date, we cannot decipher this regulatory code, despite the cells ability to read it in natural and artificial sequence contexts, and in contrast to our detailed understanding of the genetic code, which allows us to seamlessly translate DNA into protein sequences. Here, I propose a regulatory genomics approach in Drosophila with three specific objectives: First, we will determine the sequence basis of how individual Hox transcription factors (Scr, Antp, Ubx, abd-A, Abd-B) and factors downstream of signalling pathways (Sd, pan, ci, Su(H), pnt, Stat93E, Mad, Smox, CrebA) regulate different genes in different tissues. We will perform tissue-specific ChIP-Seq and measure gene expression in mesoderm/muscle, epidermis, and neurons, and explain common and tissue-specific targets by their sequences. Second, we will determine requirements for enhancer function in several different cell-types, by performing an exhaustive and unbiased enhancer screen and computationally analyzing the sequences. Third, we will build a computational model to extract general rules from objectives 1 &amp; 2, learn the regulatory codes, and make specific predictions. We will validate our model using cross-validation and predictions with unrelated sequence (e.g. from yeast), and will finally use it to design enhancers that are active in specific cell-types or combinations of cell-types. Our combination of experimental and computational methods makes us confident that we will make major contributions to the understanding of gene regulation in the fly. We anticipate that we will learn general principles, which will hold across tissues and animals, and might ultimately lead to the general regulatory code.

Keywords: gene regulation,transcriptional regulation,regulatory genomics,regulatory code,enhancer function,transcription factors
Revealing the molecular architecture of integrin mediated cell adhesion (INCEL)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: Switzerland,Israel
Call:  (ERC-2009-StG, 2009)
Start date: 2009-11-01
End date: 2015-10-31
Duration (months): 72.0
Total project cost (EUR): 1294000.0
EU funding (EUR): 1294000.0
Participants: 2
Project status: CLOSED

Cell adhesions play an important role in the organization, growth, maturation, and function of living cells. Interaction of cells with the extracellular matrix (ECM) plays an essential role in a variety of disease states , inflammation, and repair of damaged tissues. At the cellular level, many of the biological responses to external stimuli originate at adhesion loci, such as focal adhesions (FA), which link cells to the ECM . Cell adhesion is mediated by receptor proteins such as cadherins and integrins. The precise molecular composition, dynamics and signalling activity of these adhesion assemblies determine the specificity of adhesion-induced signals and their effects on the cell. However, characterization of the molecular architecture of FAs is highly challenging, and it thus remains unclear how these molecules function together, how they are recruited to the adhesion site, how they are turned over, and how they function in vivo. In this project, I aim to conduct an interdisciplinary study that will provide a quantum step forward in the understanding of the functional organization of FAs. We will analyze, for the first time, the three-dimensional structure of FAs in wild-type cells and in cells deficient in the specific proteins involved in the cell-adhesion machinery. We will study the effect of specific geometries on the functional architecture of focal adhesions in 3D. A combination of state-of-the-art technologies, such cryo-electron tomography of intact cells, gold cluster chemistry for in situ labeling, and modulation of the underlying matrix using micro- and nano-patterned adhesive surfaces, together with correlative light, atomic force and electron microscopy, will provide a hybrid approach for dissecting out the complex process of cell adhesion.In summary, this project addresses the properties of FAs across a wide range of complexities and dimensions, from macroscopic cellular phenomena to the physical nature of these molecular assemblies

Keywords: cryo-electron tomography,cell adhesion,coloidal chemistry