Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MIcroelectronics RELiability driven by Artificial Intelligence (MIRELAI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria,Italy,Germany,Netherlands,Belgium,Switzerland,United Kingdom
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-10-01
End date: 2027-02-28
Duration (months): 53.0
Total project cost (EUR): 3705678.51
EU funding (EUR): 3075944.4
Participants: 21
Project status: SIGNED

The European microelectronics (ME) industry has a direct impact on approximately 20% of the European GDP and employs over 250,000 people, with more than 64,000 job vacancies. The main technological challenges are 1) to increase both the reliability of the manufactured electronic components and systems (ECS) and sustainability to meet the requirements of the new EU directive Right to Repair, and 2) to reduce the huge product verification effort (70% of total product development time) that represents a substantial burden on costs and resources. To compete with China and North America, the European ME industry is in critical need of cross-discipline experts in electronic manufacturing and digital innovations: software, data and artificial intelligence. The main goal of the MIRELAI industrial doctorate programme is to train the next generation of engineers and scientists for the next generation of reliable and repairable ECS developed within a trustworthy European value chain. The scientific approach is based on three pillars: 1) physics of degradation, 2) multi-scale modeling and 3) AI-based reliability which in sum will add up to a reinvention and new level of efficiency for the ‘design for repair and reliability’ for ECS. Our unique industry-academia partnership of 8 industries, 4 SMEs and 9 research organisations and academic institutions from 7 European countries has all the expertise, experience and capacity along the electronics system value chain to deliver this ambitious research and training programme. Shared hosting and joint supervision by industry and academia of each of the 13 doctoral candidates ensures optimal knowledge transfer. Together, we will pave the way for sustainable, repairable and energy efficient electronic system designs and resource-friendly smart electronics applications. MIRELAI is thus perfectly aligned with the European research agenda and the EU Pact for Skills, a shared engagement model for skills development in Europe.

Keywords: microelectronics reliability,physics of degradation,digital twin,design for reliability,physics informed machine learning,multi scale and multi physics modelling,material characterization
Agricultural-climatic interactions on the control of stream dissolved organic matter trends (COSTREAM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-05-01
End date: 2024-04-30
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: CLOSED

The rising trends in terrestrial dissolved organic matter (DOM) concentrations in streams have become a serious environmental issue in many catchments of the northern hemisphere. Indeed, DOM impairs water quality and affects the biogeochemical and ecological functioning of aquatic ecosystems. Knowledge gaps in drivers controlling seasonal and interannual variations of stream DOM limit our ability to provide measures that may be implemented by decision makers in order to mitigate the continuing trends. In rural landscapes, agricultural practices interact with climatic drivers to affect biogeochemical cycles, however these interactions and their impacts on stream DOM dynamics over different timescales have not been considered so far. The ambition of COSTREAM is to provide a better understanding of the linkages between management actions and stream DOM variability both spatially and temporally in order to enhance science-based management and restoration solutions. The project will combine field and experimental studies in a well-equipped agricultural catchment with data mining of long-term records collected in the French Brittany region. The main objectives are 1) to investigate the impact of nitrogen mineral fertilizer on the production of terrestrial DOM at the seasonal scale, and 2) to determine how land use management plans during the last decades have interacted with shifts in climatic drivers to regulate stream DOM patterns at the regional scale. The COSTREAM project has potentially strong impacts on both scientific and societal perspectives. Thanks to this project, the experienced researcher will receive a unique multidisciplinary scientific training by INRAE that will reinforce significantly his expertise for future research activities and open new perspectives for both academic and non-academic careers.

Keywords: dissolved organic matter long term trends headwater catchments transfer seasonality
Cellular crosstalk driving Tertiary Lymphoid Structure formation across tissues (TissueLymphOmics)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 2
Project status: SIGNED

Formation of Tertiary Lymphoid Structures (TLS) is a recurring consequence of chronic tissue inflammation and autoimmunity, as well as several solid tumours. TLS originate in various tissues from infiltrating cells attracted by local signalling cascades. These structures can enhance local immune response by, similarly to Secondary Lymphoid Organs (SLO), functioning as spots for lymphocyte activation upon antigen recognition. However, the cellular interactions driving TLS emergence and function across tissues are not fully known. This proposal aims to unravel and characterise the cell-cell interactions involved in the formation and maintenance of TLS, in particular their tissue specificity and relationship to autoimmune diseases. A comprehensive understanding of intercellular interactions will be obtained from publicly available and newly generated single-cell RNA-sequencing (scRNA-seq) datasets from TLS-containing tissues of autoimmunity patients. Molecules involved in key signalling interactions will be spatially resolved by assessing their tissue expression using spatial transcriptomics. Then, using mouse models where TLS triggering can be controlled, scRNA-seq data will be obtained to outline a time course of TLS formation in different tissues, revealing the temporal role of the discovered interactions and their specific function in each tissue and when compared with SLOs. Finally, regulation and downstream effects of ligands and receptors will be unraveled with multiome (RNA+open chromatin) sequencing using human tonsil organoids. The observed effects will be generalised to other tissues using machine learning and deep learning models, resulting in a tissue-specific reference of signalling and regulatory genes controlling TLS biogenesis. Overall, this project aspires to provide a detailed look into TLS biology, while defining the bases for their therapy-oriented manipulation.

Keywords: tertiary lymphoid structures,tissue specifity,scrna seq,cell cell communication,autoimmunity
Ecological Sentinel (EcoSentinel)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Italy,Netherlands,France
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2024-12-01
End date: 2027-12-31
Duration (months): 37.0
Total project cost (EUR): 2909251.25
EU funding (EUR): 2909251.25
Participants: 6
Project status: SIGNED

The EcoSentinel project envisions a groundbreaking transformation in our relationship with nature to address pressing global sustainability challenges as biosphere integrity degradation, fostering a harmonious coexistence between technological innovation and environmental conservation; culminating in a community of Ecological Sentinels (EcoSentinel). Specifically, EcoSentinel leverages the biological processes and the resilient nature of living plants to give them the necessary means (i.e., energy harvesting and electromagnetic signal propagation) to become self-sustained digital nodes of a network able to autonomously monitor themselves. This revolutionary approach aims to enhance our capacity to safeguard forests and other ecosystems. The EcoSentinel technology will introduce a carbon-negative wireless communication system, powered by the ecosystem itself, enabling environmental monitoring to prevent and mitigate critical events such as wildfires and biodiversity loss. The EcoSentinel project proposes a new form of plant-plant interaction by elevating it to a digital level. By enhancing plants’ interconnection through cybernetical implants, we embark on a path to digitally transform the greenery. This unprecedented approach aims to establish a novel wireless plant-based communication system, using plants as natural antennas, uniquely powered by the integration of plant-microbial electricity generation seamlessly blended into the vegetation.

Keywords: plant based communication system plant as antenna booster plant energy harvesting
The role of intestinal antigen-presenting cells in generating T cell-mediated antifungal immunity (Candida immunity)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: SIGNED

Intestinal fungi are an important component of the microbiome and their homeostasis/dysbiosis constantly shapes the immune responses. The human commensal fungus Candida albicans colonizes the gut of 40-80% of individuals. However, life-threatening infections caused by this fungus are relatively rare since the unwinding of its pathogenic potential is kept in check by the immune system. In line with this, immunodeficient patients suffer often from Candidiasis, which is typically difficult to treat. Candida albicans induce strong Th17 response which is the main protective mechanism against pathogenic fungi. Candida-induced Th17 cells can protect the host not only against other fungal but also against extracellular pathogens. Besides the positive effects of Th17 in defence against pathogens, recent studies connect fungi-elicited Th17 response with local and gut-distal pathologies such as asthma, multiple sclerosis, Crohn’s disease, or rheumatoid arthritis. Despite that the role of Th17 is relatively well studied, the early events at the initiation of innate and adaptive immune responses against intestinal fungi are much less known. Various mutations in the adaptive immune system are clearly associated with impaired antifungal immunity. The proposed project will fill this knowledge gap by systematic studies of antigen-presenting cells involved in initiating Th17 response upon Candida colonization. We propose to use single-cell RNA sequencing techniques to determine Candida responsive populations followed by deletion of MHCII on selected APCs populations to prove that the effect is mediated via antigen presentation. We will further study the bidirectional interaction between Candida and APCs in these mice. This study will lead to the understanding of events at the beginning of antifungal response via the identification of cell type(s) responsible for Th17 induction as well as the regulation of fungal homeostasis and control of Candida virulence.

Keywords: anti fungal immunity,antigen presenting cells,th17 cells,candida albicans,candida colonization,single cell rna seq
multI-discipliNary, multi-Sectoral and multi-national trainIng network on Digital biomarkErs for supraventricular arrHythmia charactErizAtion and Risk assessmenT (INSIDE-HEART)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Sweden,Spain,Israel,Finland,Netherlands,France
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-11-01
End date: 2027-10-31
Duration (months): 48.0
Total project cost (EUR): 3231972.0
EU funding (EUR): 2667693.6
Participants: 16
Project status: SIGNED

INSIDE-HEART brings together universities, companies and hospitals from countries (Italy, Finland, France, Israel, Netherlands, Spain, and Sweden) with the main scope of establishing a multi-disciplinary network to tackle the design and the early-phase validation of digital biomarkers, specifically targeting the diagnosis of supraventricular arrhythmias (SVAs) and their associated potential for adverse risk assessment, via the joint combination of signal processing, artificial intelligence and non-clinical devices. This will be achieved by performing excellent research through a unique doctoral training “without walls” among field-expert academic, industrial and clinical entities. The composite nature of the INSIDE-HEART network ensures a highly qualified training and research infrastructure for the specific goal, which aims to generate a new profile of researcher with multi-sectoral expertise able to fill the existing gap, i.e., the absence of digital biomarkers for SVAs reliably estimated with non-clinical devices, taking into account basic research, clinical needs and business interests. Research and training are designed to consider relevant aspects such as public concern of private data management, gender and ethics related to SVAs, all according to Responsible Research & Innovation principles and Open Science practices. All activities in INSIDE-HEART are designed to pursue innovation in three domains: i) Educational domain – by implementing a new multi-sectoral paradigm of PhD training to shape modern professional researchers with cross-competencies in the field, and able to accelerate the translation from basic science to market and clinics; ii) Basic science domain - by producing new knowledge about digital biomarkers by means of a multi-sectoral approach to explore the complex aspects related to SVAs; and iii) Technological domain – by developing new data-driven and model-based methodologies to compute digital biomarkers and support the clinical decision.

Keywords: digital biomarkers,artificial intelligence in medicine,cardiovascular risk quantification,supra ventricular arrhythmias,clinical and industrial translation
Technological Innovations in Costume Practice (TICP): Enabling the adoption of new manufacturing technologies by live performance costume professionals (TICP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-15
End date: 2025-12-14
Duration (months): 13.0
Total project cost (EUR): 116747.8
EU funding (EUR): 116747.8
Participants: 1
Project status: SIGNED

The production of stage costumes relies on the talents and expertise of diverse costume professionals. These practitioners employ a range of tools and technologies as they collaboratively work to convert an idea or 2D sketch into a 3D garment custom-made for that character and show. Industry 4.0 manufacturing technologies, such as virtual patternmaking and 3D printing, offer substantial productivity, financial, sustainability and creativity benefits to costume construction, but the adoption of such technologies is haphazard and obstructed by a perception that costume practice is not technically innovative. This perception is informed by systematic gender biases that limit investment in, and recognition of, the skills and creativity of costume professionals, who are predominantly female. Technological Innovations in Costume Practice (TICP) is a research justice project that investigates the integration of technological innovations with the aim of facilitating their adoption and application in the work of costume makers. This will elevate the field of costume production and strengthen the future employability of professional costumers. The central research question driving the project is: As costume practitioners implement new manufacturing technologies in their workflow, what are the structural and attitudinal factors that constrain and facilitate their adoption? Through a groundbreaking cross-disciplinary approach that applies theories about sociotechnical change to data from practitioner interviews and digital ethnography, the project will develop a model of technological adoption for costume that responds to the very specific context of the live performance industry. Such a model will enable practitioners to be more deliberate, effective and empowered when engaging with new manufacturing technologies. The project results will centre the feminised area of costume at the cutting edge of a currently very male-gendered technical production research discourse.

Keywords: costume live performance technological adoption and diffusion
ORCHID: Organic Reactions through Carbon addition to H2 on Interstellar Dust grains (ORCHID)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

The recent progress in astrochemical studies of the molecular makeup of the Interstellar Medium (ISM) has revolutionized our understanding of the early phases of star and planet formation. A significant gap, however, still exists and that involves the role of molecular hydrogen (H2)—the most abundant molecule in the universe—in interstellar ice chemistry. ORCHID aims to fill this gap by investigating the impact of H2 on the formation and evolution of complex organic molecules (iCOMs) in the ISM. Given the lack of existing literature detailing solid-state reaction pathways incorporating H2, ORCHID hypothesizes that H2 reactions with carbon atoms is instrumental in unexplored chemical pathways for iCOMs formation. To achieve its objectives, ORCHID uses state-of-the-art experimental setups to produce quantitative data that aligns with the latest observations of interstellar ices from the James Webb Space Telescope (JWST) and gas-phase observations from radio-telescopes like the Atacama Large Millimeter/submillimeter Array (ALMA). Specifically, the project: (1) explores iCOMs formation through previously overlooked pathways involving H2, completing and extending reaction networks in the ISM; (2) generates accurate parameters for astrochemical models, facilitating simulations that match observations of star- and planet-forming regions; (3) investigates the conditions under which iCOMs are released into the gas phase, especially at temperatures where thermal desorption is not feasible in the ISM. The insights and data generated by ORCHID will serve as a robust foundation for interpreting ongoing and future astronomical observations. Moreover, the project will enrich existing gas-grain kinetic models, effectively bridging the grain-gas gap and thereby advancing our understanding of how chemical processes in the ISM influence the composition of celestial bodies in star- and planet-forming regions.

Keywords: laboratory solid state interstellar ices interstellar complex organic molecules temperature programmed desorption infrared spectroscopy
Ferroelectric PHOtonics ENablIng novel functionalities and enhanced performance of neXt generating PICs (PHOENIX)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Partnership: Photonics (co-programmed)
Countries involved: Belgium,Spain,Israel,Switzerland,United Kingdom,Czechia
Call: Advanced Photonic Integrated Circuits (Photonics Partnership) (RIA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-09-01
End date: 2026-02-28
Duration (months): 42.0
Total project cost (EUR): 2820937.5
EU funding (EUR): 2820937.5
Participants: 8
Project status: SIGNED

In PHOENIX, we create the next generation of compact photonic integrated circuits (PIC) offering a continuous and efficient control over optical signals. A barium titanate (BTO) on silicon nitride (SiN) platform will be optimized to enable novel functionalities and produce enhanced PICs. The novel functionalities stem from a combination of materials having a metal-insulator transition with epitaxial ferroelectrics. Vanadium oxides (VOx) deliver a maximum contrast in absorption while Barium Titanate (BTO) offers an efficient and programmable control of the phase of an optical signal through Pockels and photorefractive effects. The developed technologies will be demonstrated in four uses cases in high-impact emerging applications: 1) fully homomorphic encryption, 2) 5G infrastructure, 3) inference of deep neural networks and 4) training of deep neural networks. The project has four main objectives: a) to provide novel photonic technologies with enhanced functionalities thanks to the integration of VOx and BTO, b) to provide a BTO/SiN waveguide platform for subsequent manufacturing of PICs and an upgraded version of such a platform integrating VOx with the potential to improve their performance and scalability, c) to build up the demonstrators, and d) to advance in the understanding, realization and upscaling of high-quality oxide thin-films by molecular beam epitaxy (MBE) on large area. The validation of the developed technology will be completed with an extrapolation to benchmark against representative existing systems and a roadmap for photonic-electronic integration. The project will perform a market analysis and a techno-economic evaluation in order to define business models and exploitation plans that ensure the sustainability of the PHOENIX platform to reduce innovation-to market-time and R&I costs for disruptive high-tech SMEs and maximize the impact of the 4 user cases demonstrators.

Keywords: batio3,bto,vo2,v2o3,vanadium oxide,photorefraction,pockels effect,metal insulator transition,fully homomorphic encryption,fhe,inference,training,neural networks,neuromorphic computing,5g