Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Commercialization of 3D histopathological evaluation of osteoarthritis – new tools for therapy monitoring from preclinical testing to hospitals (MUOTO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Finland
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Osteoarthritis (OA) is the most common musculoskeletal disease. OA has significant socio-economic impact as it severely affects the quality of life, reduces productivity and carries higher risk of mortality. However, the development of new treatments for OA is painstakingly long and very challenging. There are many clinical OA drug trials that have ended in a failure. In my ERC-StG project, we have developed 3D histopathological evaluation method of OA from micro-computed tomography (μCT). It allows detecting narrow cracks and surface irregularities that are associated with very early OA. Importantly, with our novel method deterioration and degradation of joint surfaces can be analysed much earlier than with any other non-invasive imaging solution. The key is in pinpointing the most important histological changes with the highest reliability while retaining the anatomical information, lost in the conventional histology. This is expected to decrease the number of histological evaluations by 20-fold, saving substantial amount of time, and consequently, money. We will significantly add value to pharmaceutical industry developing new therapies for OA. Eventually, our solution speeds up the time-to-market for new and more effective OA drugs, while saving in R&D costs. Later on, we can offer inexpensive, effective and accurate diagnosis and prognosis tool for OA patients. Gradually, we will gather a big data repository of various compounds and their effects on OA. From this data, and with the help of Artificial Intelligence engine, we can visually show the predicted compound efficacy, or suggest a drug combination never imagined earlier. In this PoC, the commercialization planning is carried out with a focal point on Software as a Service (SaaS) business model. We will also improve the adoptability of our innovation (e.g. visualisation of the OA severity, positioning in the value chain) and plan the big data business strategy.

Keywords: osteoarthritis,histopathology,preclinical models,articular cartilage degeneration,software as a service
Toward a Digital Twin ECS and thermal management architecture models: Improvement of MODELICA libraries and usage of Deep Learning technics (TWINECS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Spain,Belgium
Call: Toward a Digital Twin ECS and thermal management architecture models : Improvement of MODELICA libraries and usage of Deep Learning technics (H2020-CS2-CFP10-2019-01, 2019)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 589945.0
EU funding (EUR): 589945.0
Participants: 3
Project status: SIGNED

The project global goal is to develop an efficient, robust, and accurate model to simulate e-ECS under the Dymola/Modelica framework based on libraries provided by the Topic Manager. The central focus is placed on the major challenges underlined in the Clean Sky 2 MALET project which include the efficient simulation of the Vapor Compression System (VCS), the VCS heat exchangers, and the electrical components. The project modelling approach is twofold as both physical and surrogate models must be developed and integrated into the Dymola/Modelica framework. The TwinECS specific objectives are summarized as follows: • Development of thermo-fluid models: VCS heat exchangers and their successful integration in assembled VCS models. • Development of electrical models for: motor, power inverter, ATRU, IGBT and MOSFET. • Development of surrogate models of the aforementioned thermo-fluid and electrical components based on data analytics technics. • Simulation of a complete thermo-fluid-electrical VCS model using both the standard and the surrogate models.

Keywords: environmental control system,thermo fluid system modelling,electrical system modelling,dymola,modelica,surrogate modelling
Gradual and abrupt environmental change: connecting physiology, evolution and community composition (Gradual_Change)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2023-09-30
Duration (months): 84.0
Total project cost (EUR): 2390598.0
EU funding (EUR): 2390598.0
Participants: 1
Project status: SIGNED

A major goal in ecology is to predict how environmental changes, including drivers of global change, affect communities and ecosystem functioning, with society demanding answers to these pressing questions. A key limitation of virtually all experimental approaches addressing such questions is that treatments are delivered abruptly, while many changes occurring in nature are gradual. Here I propose to comprehensively study consequences of environmental change when delivered abruptly vs. gradually. In order to understand and model effects of gradual vs. abrupt changes, we need to simultaneously consider physiological effects (e.g. acclimation), evolutionary changes (e.g. adaptation) and changes in community composition and functioning. Even though changes at these levels likely interact, there is no study in which physiology, evolutionary changes and community shifts have been studied in response to a changing environmental factor. This research program thus enters unchartered territory of empirical environmental research in proposing work at this nexus of physiology, environmental change and community composition/ function. I focus on soil fungi, key players in terrestrial ecosystems, testing a range of gradually vs. abruptly changing environmental factors, in a range of soils, in the field and in microcosms. We connect differential responses to species traits, apply modeling and employ data syntheses across all biomes and organisms to achieve high external validity. We carry out a set of core experiments that will afford unprecedented insight into the nature of change in a community context in response to warming, focusing on soil fungi. In these we follow evolutionary change (phenotype and genotype), test physiological shifts by re-isolation of fungi and monitor community changes. This work will have transformative character in providing not only new mechanistic insights into effects of environmental change, but will also represent a step change in fungal ecology.

Keywords: global change
Easily diStributed Personal RapId Transit (ESPRIT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Germany,Spain,Italy,Germany,Italy,France,France,France,France,France,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Luxembourg
Call: Electric two-wheelers and new ultra-light vehicle concepts (H2020-GV-2014, 2014)
Start date: 2015-05-01
End date: 2018-10-31
Duration (months): 42.0
Total project cost (EUR): 7996591.25
EU funding (EUR): 7996591.25
Participants: 21
Project status: CLOSED

Today, transportation both to/from city-centres and within peri-urban areas, is unsatisfactory in terms of congestion, environmental and societal aspects. To answer identified needs, the Easily diStributed Personal RapId Transit (ESPRIT) project aims to develop a purpose-built, light weight L6 category electric vehicle that can be stacked together to gain space. Thanks to pioneering coupling systems, up to 8 ESPRIT vehicles can be nested together in a road train, 7 being towed for an efficient redistribution of fleets and a smartly-balanced and cost efficient transport system. Within the project, 2 user scenarios are foreseen: a one-way carsharing system within city centres and a last-kilometre personal mobility system to existing public transport infrastructures in peri-urban areas. These will be tested through 3 different geographical use cases (Glasgow, Lyon and L’ L’Hospitalet de LLobregat near Barcelona). This innovative transport system concept will be demonstrated to TRL5 though state-of-the-art developments of diverse technological bricks (including vehicle and road train architecture, coupling and guiding systems, kinetic and dynamic behaviour management systems, efficient energy supply and rapid charge battery strategies). To prove the ESPRIT concept, the project will also work on modelling and simulation tools to predict, once ESPRIT vehicles are deployed, the economic, social and environmental benefits as well as key operating strategies. This concept will incite citizens to use public transport and carsharing solutions rather than their private vehicles leading to seamless intermodal transport, decongestion, significant reduction of noise and air pollution. To reach all stakeholders, the ESPRIT project will not only rely on its technical expertise but also on the knowledge and network of its end user community represented by several partners as well as the Advisor Board which includes carsharing organisations, public authorities and transport operators.

Keywords: carsharing,electric vehicle,public transport,last kilometer,road train,zero emission vehicle,lightweight vehicle,stackable vehicle,trackless,electrically linked vehicles,seamless transport
Ultrasound Cavitation in Soft Materials (UCOM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Germany,Switzerland,Switzerland,China,France,France,Netherlands,United States,United Kingdom,United Kingdom,Japan,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2018-10-01
End date: 2023-05-31
Duration (months): 56.0
Total project cost (EUR): 4191688.6
EU funding (EUR): 4191688.6
Participants: 17
Project status: SIGNED

The pressures and temperatures developing during the interactions of shockwaves with cavitation bubbles and soft matter induce complex phenomena, both at physical and biochemical levels. These have a non- exhaustive range of relevant applications including ultrasound-based therapies, surface cleaning and food processing. Our aim is to explore these processes both in micro and macroscales using experiments and to develop new computational capabilities for their simulations. Measurements will include temperature/ species forming in collapsing bubbles, identifying chemical reactions and possible tissue interaction, such as protein denaturation and agglomeration; tissue cavitation threshold and its control using nanoparticles, allowing development of new cavitation-mimicking-tissue materials extrapolating to actual tissue properties that will be used for in-vitro testing of equipment with minimum collateral damages. Computations will be based on advanced multi-resolution methods coupling fluid flow, chemical reactions and deforming material mechanics solvers, with physically consistent thermodynamic closure models for the involved materials; pressure wave propagation, bubble nucleation and material damage effects will link microscale phenomena to macroscale. Uncertainty quantification techniques will link computations with experimental data. UCOM builds upon the strong foundations of the PIs and their teams in training researchers in computational and experimental methods on cavitation and their strong record to successfully integrate research and technical applications. The final goal of the research and training program is to explore the enormous potential of the new and experimentally validated computational tools to guide breakthrough innovations and high-impact, high-tech technologies ranging across different sectors that all eventually enhance their careers and will be serving the well-being.

Keywords: cavitation,ultrasound,simulation,cleaning,soft materials,bubble dynamics
Plytix Information Sharing Platform and Analytics (PISPA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain,Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 2031875.0
EU funding (EUR): 1422312.5
Participants: 2
Project status: CLOSED

The problem: Booming online trading activity has triggered an increasing interest for data analytics, which can largely boost online sales. With billions of clickstream and transactional data taking place every day on the internet, e-commerce is clearly a key domain for data mining and analytics. Supply chain management and the forecasting of online sales could immensely benefit from such data mining/analytics. However, today, brands only have access to data intelligence from e-tailers in terms of sales numbers, and most often, this data comes too late to be valuable. More importantly, currently marketed analytics tools are not able to track the performance of the brands’ products through 3rd party retailers. The solution: Plytix developed a breakthrough analytics tool – Plytix Analytics – that is expected to become a new standard in e-commerce. Unlike all other web analytics tools, Plytix tracks product performance (not sites) directly and across websites – thereby bringing more value/insights for each given product. Plytix Analytics enables users to extract valuable insights that allows them to: [i] optimize prices; [ii] make better marketing decisions and design better products; [iii] optimize inventory to prevent stock-out; [iv] prevents online parallel import, etc. The market: The total market size for Plytix in the targeted markets is above EUR 31.5 billion per year. The implementation of the innovation project will place Plytix.com ApS in a strong position to exploit an aggregated turnover exceeding € 41 million – five years after the project kick off.

Keywords: e commerce,web analytics,online marketing,platform business
Smart optical and ultrasound diagnostics of breast cancer (SOLUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Italy,Austria,Germany,Italy,France,France,France,United Kingdom
Call: Photonics KET 2016 (H2020-ICT-2016-1, 2016)
Start date: 2016-11-01
End date: 2021-10-31
Duration (months): 60.0
Total project cost (EUR): 3815260.0
EU funding (EUR): 3815260.0
Participants: 9
Project status: CLOSED

SOLUS is a trans-disciplinary 54-month project bringing together 9 partners: industries (4), academic and clinical institutions from 5 countries (engineers, physicists and radiologists) representing cutting-edge expertise in their fields, to develop an innovative non-invasive, point-of-care, low-cost, easy-to-operate, multi-modal imaging system (diffuse optics and ultrasounds/shear wave elastography) for high-specificity diagnosis of breast cancer, the most common female cancer in Europe. Mammographic screening is effective in reducing mortality, however the 10-year cumulative false-positive risk is 50-60%, leading to needless additional invasive procedures (e.g. biopsy). The project addresses the unmet clinical need for higher specificity in breast cancer imaging following screening by fully combining photonics with non-photonics techniques, developing and clinically validating innovative and previously unthinkable photonics concepts and components: time-domain small source-detector distance optical tomography, miniaturized picosecond pulsed laser sources, high-dynamic-range time-gated single-photons detectors to achieve unprecedented sensitivity and depth penetration. For the first time, this allows a comprehensive quantitative characterization of breast tissue including composition (water, lipids, collagen), functional blood parameters, morphologic information and mechanical parameters (stiffness). This innovative multi-parametric characterization will significantly improve the specificity of breast screening, with great impact on the quality of life of millions of European women every year, and huge savings for the healthcare systems. The strong involvement of leading industrial players at all levels in the value chain will push the European innovation process and make a significant contribution to ensuring Europe’s industrial leadership in the biophotonics healthcare market, while addressing one of the largest societal challenges in health and well-being.

Keywords: breast cancer,non invasive diagnostics,oncology,ultrasonics,biomedical optics
Interactions of insect and soil microbial communities with insect pathogenic fungi (INMIfungi)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Entomopathogenic fungi belong to the most important antagonists of arthropods in soil. Due to their antagonistic function, entomopathogenic fungi have a great potential for us in biological control of insect and mite pests. However, knowledge on how abundance and diversity of these fungi is affected by environmental factors is limited. While a number of studies have assessed effects of abiotic factors, effects of biotic factors such as microbial and arthropod communities have remained largely unassessed. The goal of this project is to investigate the interactions of microbial and arthropod communities with the entomopathogenic fungal genera Metarhizium and Beauveria and how abundance and diversity of the two genera might be affected by the two biotic factors. Analyses will be performed in soils obtained from 30 sites representing three habitat types with different management intensities (crop, grassland, forest) in Switzerland. Multilocus SSR-marker genotyping and high-throughput amplicon sequencing will be used to assess genetic diversity of Metarhizium spp. and Beauveria spp. and microbial and arthropod diversity in the soil samples. Multivariate statistics will be applied to investigate correlations among different abiotic and biotic factors and Metarhizium and Beauveria abundance and diversity. The project will provide novel insight on how entomopathogenic fungal populations interact with soil biota and fill important knowledge gaps. It will provide basic data to further exploit their use for biological pest control, a significant factor for implementation of sustainable agriculture. Experiments planned will involve state-of-the-art NGS technology and require further adaptation of the technology for application in an area in which its use has been limited. In addition, the project has a strong training component for the applicant including acquisition of up-to-date methods and the opportunity to develop research leadership and professional maturity.

Keywords: insect pathogenic fungi,metarhizium,beauveria,soil biotic factors,next generation sequencing,soil microbial communities
Captive Customer Connection: Easy and Secure Sharing and Selling of Tickets - and Other Personal Rights (keyper)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-10-01
End date: 2019-12-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Mobile purchases via smartphone and online ticket sales have increased rapidly in recent years. However, in the field of mobile ticketing, very little has changed. Print@home tickets are becoming increasingly popular, and wallet alternatives such as Apple's Passbook are also finding more uses. However, the organizers' implementations are not user-friendly and do not cover the needs of ticket buyers and sellers. keyper is a SaaS toolset to specify rules for right transfer from, to and among customers. Our service is fast, easy, secure, mobile, with or without payment, and it generates more revenue. The first application is to solve the ticketing challenge as keyper allows transferring tickets to anyone at any time and the organizer knows who the person is that eventually attends the event. The keyper SDK technology can be white-labelled by event organizers and integrated into their existing ticketing solutions. Our technology can be extended to and combined with several internal or external sales boost solutions. Our innovation gives us access to the €55 billion event ticket total market and €5 billion European sports tickets market. Our goal is to be part of the 34 billion ticket transactions that will happen from 2018-22. We follow an SaaS-based subscription model with three different levels depending on the amount of ticket and support plan. Our suppliers are hosting and utility companies. Our clients are any companies that sell tickets such as event organizers and sport clubs. And just as it can be used for tickets, keyper can be used for any type of personal right assignment. keyper is disruptive as it enables handing out tickets, which is otherwise possible in only a few cases – keyper creates the market of reassigned tickets for a fee. If consumers buy a ticket from a company that uses keyper, they can hand on and even sell tickets without any hassle.

Keywords: personal rights transfer,personal rights assignment,ticketing