Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding the Effect of Non-natural Fluid Environments on Enzyme Stability (FLUIZYME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Denmark
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2352846.0
EU funding (EUR): 2352846.0
Participants: 1
Project status: SIGNED

Enzymes are the protein-based catalysts found throughout nature and are of immense scientific importance, and of great practical value in medicine, chemistry and biotechnology. In most practical applications (such as industrial biocatalysis), enzymes are exposed to non-natural conditions, resulting in a loss of stability. Our understanding of what leads to a loss in enzyme stability under these conditions is very poor and therefore the aim of this project is to obtain such understanding. Current studies on enzyme stability mostly measure thermodynamic stability, and in some more limited cases operational stability, after exposure to different conditions (such as different temperatures and pH values). However, they overlook the effect of mixing, exposure to high concentrations of reactant and product as well as to dynamic fluid-fluid interfaces, all of which are common in a most practical applications. This project aims to understand the effect on enzyme stability of exposure to such non-natural conditions, using designed experiments in novel apparatus (mimicking industrial conditions), complemented by a suite of analytical characterization tools. The result of such studies will firstly enable the re-design of suitable equipment for industrial biocatalysis, which is of increasing interest as an alternative catalytic method for the synthesis and production of a vast array of valuable products. Secondly, the knowledge gained will be of great importance for protein engineering, providing the basis for pre-screening of enzymes on the basis of stability. Finally, the results will also have implications for other areas of bioprocessing, including microbial fermentation for the extracellular to produce enzymes and cell culture to produce therapeutic proteins.

Keywords: biocatalysis,bioprocessing,proteins,enzymes,stability,mixing,static interfaces,dynamic interfaces,cycling
Nitrogen-enriched plasma activated water, an unparalleled plant feeding system (Plan2fix)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-09-01
End date: 2021-12-31
Duration (months): 28.0
Total project cost (EUR): 2025605.0
EU funding (EUR): 1417923.5
Participants: 1
Project status: CLOSED

Horticultural producers fertilise their crops with Nitrogen (N) to ensure healthy and abundant yields that meet the needs of an increasing population. EU greenhouse farmers spend € 808 M yearly in synthetic N-fertilisers, which are energy-intensive to produce, heavily dependent on fossil fuels and very pollutant. Moreover, the supply chain of synthetic N-fertilisers entails a great amount of GHG emissions, with costs estimated at €14 B/yr. Fertilisation with synthetic fertilisers is unsustainable particularly in EU as the price of N is highly dependent on changes in the price of natural gas. VitalFluid brings to market a sustainable and non-polluting alternative to current synthetic N-fertilisers. Our PLAsma Nitrogen FIXation technology provides an on-the-spot production of liquid N-fertiliser that makes the current supply chain of fertilisers redundant. Only with air, water and electricity from renewable sources, our innovative patented plasma activation technology extracts N directly from the air and dissolve it into Plasma Activated Water (PAW) which is nitrate-enriched water ready to be supplied to crops. PLAN2FIX will provide the agriculture sector and society with lower cultivation costs and third parties’ dependency, ensured availability of fertilisers and a drastic reduction of GHG emissions. With 500,000 Ha of greenhouses in the world and 210,000 Ha in EU, our short-term target customers are professional greenhouse horticulture growers which require more fertilisers per hectare due to intensive cultivation practice. We aim at entering leading countries in the greenhouse and advanced farming: Netherlands, Germany, Spain, France, Italy, Poland & UK in the first 5 years. We will sell directly in NL while will rely on a distribution network outside NL. From 2022 until 2026, we expect 450 units sold, €44.5 M of cumulated revenue, EBITDA of € 22M and a ROI(5Y) of 5.53. The payback of the investment is less than 2 years and we will create 22 new job positions.

Keywords: fertiliser,fertilisation,nitrogen,nitrogen fixation,plasma,plasma activated water,nitrate,sustainability
Development of Relevant Approaches to Mathematically Model Increasingly Complex Microbially-driven Processes (DRAMATIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom,Canada
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-06-01
End date: 2020-05-31
Duration (months): 36.0
Total project cost (EUR): 255349.8
EU funding (EUR): 255349.8
Participants: 2
Project status: CLOSED

Mathematical modelling has played a central role in understanding the fundamental characteristics and behaviour of ecological systems for over a century. In microbial systems, modelling has attempted to reveal the dynamics and interactions of simple co-cultures of organisms in chemostats through to more complex systems with highly diverse functionality. In real-world processes, such as engineered biological systems, EBS, (activated sludge, anaerobic digestion), the former models are incomplete for characterisation of the functional microbial diversity, whereas the latter models are intractable to mathematical analysis, rendering them as inadequate. The Fellowship will investigate the suitability of current mechanistic approaches to modelling for EBS using chemostat theory, but also exploring the analysis of higher dimensional models. The fellow will undertake their outgoing phase at McMaster University to develop their skills in dynamical system theory, applied to real-world systems and observed microbial ecological behaviour in various forms. This will include the use of both analytical and numerical methods to understand system stability and the detection of emergent properties. Recent advances in the understanding of the limits of classical Monod-type growth functions has given rise to new approaches including stochastic and diffusion-based models. However, mathematical investigation of these alternative concepts is not yet fully realised. The fellow will bridge the gap between microbial ecological theory, modelling and mathematical theory to understand the practical possibilities and predictive capabilities that can be exposed when rigorous analysis is achieved. As part of the return phase, he will spend a period at INRA, France, to investigate the validation and application of the models to real systems. This will be continued at Newcastle University, where dissemination of the outputs, including a dedicated software tool will be also be carried out.

Keywords: engineered biology,emergent behaviour,software development,microbial ecology
Conceptual study for the reconversion of LUFORT: Diversification towards high added value UHPFRC products for face internationalization (IDIFOR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

LUFORT is a precast concrete company that a year ago started to work with T-CON, a group born at the Universitat Politècnica de València, with 5 years of I+D+i experience, reaching TLR6 in UHPFRC technology. This material has two main advantages: much higher strength than ordinary concrete, leading to much lighter and thus exportable elements; and extreme durability even in aggressive environments. LUFORT is committed to introduce new innovative products made of UHPFRC for market diversification and to provide higher value to clients, repositioning the company products in new emerging market niches. LUFORT is initially focused on two products: manhole covers, as the steel-made are stolen and generate fatalities; and platforms for oyster and seafood cultivation, as the current elements are wood-made, with low durability and high environmental impact. LUFORT is planning to develop at medium term other competitive products identified. The customers of the platforms are companies that perform this activity; and manhole covers clients can be the contractor of the works, the public authorities or distributors, for complex markets. Feasibility assessment will be distributed in three parts: • Initial strategy: Contains studies of the main markets, a strategic analysis for each sector in Europe and a preliminary analysis of the most adequate regions. • Feasibility study: The technical, economical, legal, operational and scheduling feasibility will be performed. • Internationalization plan: As the company will base its income in foreign markets, the modes of entry will be defined, with a marketing and economic plan. The 2º Phase is required for the optimization of production systems, development of moulds and casting systems, certifications, full scale tests to prove strength or durability and prospection of new products. Market prospection, promotional documentation, web design, and other parts of the marketing plan will require also budget to identify and convince clients.

Keywords: uhpc,uhpfrc,new materials,precast,concrete
Innovative treatment process for biogenic waste and residual materials to manufacture compacted fuels as pellets or briquettes (Res2Pel)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Germany
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In times of declining fossil fuels and increasing problems caused by climate change, it is important to find alternative fuels to ensure an efficient and sustainable energy supply in the future. The use of wood or other energy crops especially the utilization of biomass residues is at the center of research because of the large application potential in the manufacturing of CO2-neutral biomass fuels. So, this proposal relates to the topic SIE 1 – 2014/2015. The H.J.X.W. Holding GmbH, a medium-sized Munich based company, developed the innovative treatment process “florafuel” to convert wet biomass streams into high-grade biomass fuel pellets or briquettes. The positive impact on the fuel quality is the reduction of the water content and of harmful substances such as chlorine and potassium in the biomass fractions. Moreover, mineral particles such as stones, sand, soil and metals are removed during the process which has been realized during the national project “RESPEL” into a prototype and shown very promising results. Several biomass streams such as grass and foliage have been successfully converted into fuels with a heating value of ca. 18 MJ/kg and all other properties require from the DIN EN 1496-6 in a cost-effective process. The Technology Readiness Level of the developed innovative treatment plant is assigned to level 6. Potential customers are users with organic residues up to 20,000 tons per year, like farmers, composting and biogas plant operators and municipalities. In project phase 1 a feasibility study will reveal the technical feasibility and the optimal way to reduce the manufacturing costs fostering its market uptake and show how the improved plant can be technically and economically marketable. A business plan will be developed for an optimal commercialization. These two deliverables will serve as a basis for the construction of an improved plant and its commercialization which will be conducted in project phase 2.

Keywords: bioenergy,biomass,residual materials,waste materials,landscpaing materials,innovative treatment,pellets,briquettes,biomass fuels,mixed biomass fuels
Synthesis and Performance Optimization of a Switching Nano-crossbar Computer (NANOxCOMP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Italy,Greece,Türkiye,France,United States
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2015-12-01
End date: 2019-11-30
Duration (months): 48.0
Total project cost (EUR): 577035.0
EU funding (EUR): 577035.0
Participants: 9
Project status: CLOSED

The main goal of this project is developing a complete synthesis and optimization methodology for switching nano-crossbar arrays that leads to the design and construction of an emerging nanocomputer. New computing models for diode, FET, and four-terminal switch based nanoarrays are developed. The proposed methodology implements both arithmetic and memory elements, necessitated by achieving a computer, by considering performance parameters such as area, delay, power dissipation, and reliability. With combination of arithmetic and memory elements a synchronous state machine (SSM), representation of a computer, is realized. The proposed methodology targets variety of emerging technologies including nanowire/nanotube crossbar arrays, magnetic switch-based structures, and crossbar memories. The results of this project will be a foundation of nano-crossbar based circuit design techniques and greatly contribute to the construction of emerging computers beyond CMOS. The topic of this project can be considered under the research area of “Emerging Computing Models” or “Computational Nanoelectronics”, more specifically the design, modeling, and simulation of new nanoscale switches beyond CMOS. The topic is well addressed and fit in H2020 work programmes FET (Future and Emerging Technologies) and ICT-25 (Generic Micro- and Nano-electronic Technologies).

Keywords: emerging computing models,circuit performance optimization,logic synthesis,switching,nanoarrays
Inclusive Cultural Heritage in Europe through 3D semantic modelling (INCEPTION)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Reflective societies - cultural heritage and European identity
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Germany,Italy,Cyprus,Greece,Croatia,Slovenia,Bulgaria,France,Netherlands
Call: Advanced 3D modelling for accessing and understanding European cultural assets (H2020-REFLECTIVE-7-2014, 2014)
Start date: 2015-06-01
End date: 2019-05-31
Duration (months): 48.0
Total project cost (EUR): 3990205.0
EU funding (EUR): 3990205.0
Participants: 14
Project status: CLOSED

INCEPTION realises innovation in 3D modelling of cultural heritage through an inclusive approach for time-dynamic 3D reconstruction of artefacts, built and social environments. It enriches the European identity through understanding of how European cultural heritage continuously evolves over long periods of time. INCEPTION’s Inclusive approach comprises: time dynamics of 3D reconstruction (‘forever’); addresses scientists, engineers, authorities and citizens (‘for everybody’); and provides methods and tools applicable across Europe (‘from everywhere’). INCEPTION solves the shortcomings of state-of-the-art 3D reconstruction by significantly enhancing the functionalities, capabilities and cost-effectiveness of instruments and deployment procedures for 3D laser survey, data acquisition and processing. It solves the accuracy and efficiency of 3D capturing by integrating Geospatial Information, Global and Indoor Positioning Systems (GIS, GPS, IPS) both through hardware interfaces as well as software algorithms. INCEPTION methods and tools will result in 3D models that are easily accessible for all user groups and interoperable for use by different hardware and software. It develops an open-standard Semantic Web platform for Building Information Models for Cultural Heritage (HBIM) to be implemented in user-friendly Augmented Reality (VR and AR) operable on mobile devices. INCEPTION collaborative research and demonstration involves all disciplines (both social and technical sciences), technologies and sectors essential for creation and use of 3D models of cultural heritage. SMEs are the thrust of INCEPTION consortium that will bring the innovation into creative industries of design, manufacturing and ICT. The Consortium is fully supported by a Stakeholder Panel that represents an international organisation (UNESCO), European and national public institutions, and NGOs in all fields of cultural heritage.

Keywords: building information model,advanced 3d modelling,digital documentation,interoperability,semantic models,integrated informative systems,3d survey,accessibility,user oriented apps
Enginomics in food quality design: the case of shelf-stable fruit-, vegetable- and legume-based foods (FOODENGINE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Germany,Belgium,Belgium,Belgium,France,Netherlands,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-01-01
End date: 2021-12-31
Duration (months): 48.0
Total project cost (EUR): 3437311.68
EU funding (EUR): 3437311.6799999997
Participants: 9
Project status: CLOSED

The overarching objective of FOODENGINE is to provide, for the first time, a research-based training programme to a new generation of young food scientists and technologists by introducing an enginomics approach in food quality design. It connects an omics approach to instrumentally quantify food quality with an advanced engineering approach using multi-response kinetics to model food quality changes during processing and storage. At the same time, FOODENGINE will develop models linking the enginomics-based instrumental food quality design with sensory properties, consumer acceptability and consumer preferences to create new products appealing to consumers. FOODENGINE provides unique interdisciplinary, international and intersectoral training opportunities to 13 ESRs, each for 36 months. This extensive international (5 countries), intersectoral (2 universities, 1 research institute and 6 food (ingredient) companies) and interdisciplinary (food engineering, food chemistry, food nutrition and sensory/consumer research) training should lead for all ESRs to a PhD degree. FOODENGINE will boost the career perspectives of the FOODENGINE fellows to the top level. In addition, it has the ambition to become a best-practise example for structuring PhD research training in food science and technology at the European level. Although FOODENGINE specifically focusses on sustainable commodities which are essential parts of a healthy lifestyle (fruit-, vegetable-, legume-based food ingredients and foods), the skills and new ways of thinking the fellows will acquire are generic and can be extrapolated beyond the specific application area (diverse range of food systems or food processes) in their future careers.

Keywords: food technology
Sustainable, affordable and code compliant 3D printed houses (OVO Habitat)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

3D printing has already revolutionized several industries and achieved unprecedented speed of delivery, quality and cost reduction. It has experienced a remarkable technological development in the last few years, being possible to find applications in various sectors, especially in the automotive, healthcare, aerospace or machines and tooling. 3D printing technology is therefore considered mature in high value products, although it has not yet been successfully transferred to the construction business. This is where A3D is positioning itself. A3D builds homes at fraction of the traditional cost, using sustainable materials and done on-site, reducing transportation costs, pollution, and waste. A3D has developed novel lightweight concrete formulations and 3D printing system able to build on site code compliant, sustainable and affordable houses. Our groundbreaking solution has been recognized by urban developers who are seeking to provide affordable and sustainable homes. Now, successful commercialization requires demonstrated field results. Through the feasibility study phase, we will establish the roadmap to build a full scale OVO Habitat (our first optimized design) ready to be commercialized.