Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Scientific Large-scale Infrastructure for Computing/Communication Experimental Studies - Design Study (SLICES-DS)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Cyprus,Greece,Switzerland,Belgium,Poland,France,France,France,France,Netherlands
Call: Design Studies (H2020-INFRADEV-2019-3, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 2914175.0
EU funding (EUR): 2914175.0
Participants: 13
Project status: CLOSED

Digital Infrastructures as the future Internet, constitutes the cornerstone of the digital transformation of our society. As such, Innovation in this domain represents an industrial need, a sovereignty concern and a security threat. Without Digital Infrastructure, none of the advanced services envisaged for our society is feasible. They are both highly sophisticated and diverse physical systems but at the same time, they form even more complex, evolving and massive virtual systems. Their design, deployment and operation are critical. In order to research and master Digital infrastructures, the research community needs to address significant challenges regarding their efficiency, trust, availability, reliability, range, end-to-end latency, security and privacy. Although some important work has been done on these topics, the stringent need for a scientific instrument, a test platform to support the research in this domain is an urgent concern. SLICES ambitions to provide a European-wide test-platform, providing advanced compute, storage and network components, interconnected by dedicated high-speed links. This will be the main experimental collaborative instrument for researchers at the European level, to explore and push further, the envelope of the future Internet. A strong, although fragmented expertise, exists in Europe and could be leveraged to build it. SLICES is our answer to this need. It is ambitious, practical but overall timely and necessary. The main objective of SLICES-DS is to adequately design SLICES in order to strengthen research excellence and innovation capacity of European researchers and scientists in the design and operation of Digital Infrastructures. The SLICES Design study will build upon the experience of the existing core group of partners, to prepare in details the conceptual and technical design of the new leading edge SLICES-RI for the next phases of the RI's lifecycle.

Keywords: digital infrastructure,future internet,wireless,cloud,research infrastructures,experimentation,european research excellence in digital sciences
Interdisciplinary concepts for one-step CATalytic hydrodeoxygenation of crude Glycerol-To-bioPropylene (CatGTP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-03
End date: 2023-05-02
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 2
Project status: SIGNED

The CatGTP project aims at valorising crude glycerol, which is a by-product of world-scale biodiesel industry. I will develop an innovative one-step catalytic hydrodeoxygenation (HDO) route for upgrading crude glycerol-to-biopropylene (GTP), thus contributing to overcome the challenge of olefins feedstock shortage and diversification in EU. At the University of Lille-ULille (France), I will focus the first part of project on better understanding the surface functions of MoCx≤1@OMS catalysts to assess and tune their HDO properties using a rational design approach backed-up by time-resolved spectroscopy (in situ µRaman and operando NAP-XPS techniques). This part will involve a secondment at the Max Planck Society-MPS (Germany) for elucidating the C-O catalytically active-sites and GTP pathways under near-practice HDO conditions. The second part of project will comprise high-throughput experimentations for quickly determining the main parameters affecting GTP catalytic efficiency (activity, selectivity and long-term stability), and thus, setting the optimisation-intensification bases for the GTP process. The CatGTP’s training objectives are to develop all skills necessary to get established as a full independent scientist within the area of in situ/Operando analyses of catalysed reactions and their optimisation/intensification, and further grow a fruitful collaboration with industry and between these EU labs. Combining the high-level labs-facilities and host/partner supports, I will carry out synergic multi-tasks for successfully achieving the research and training objectives set, thereby, enhancing my professional career prospects in European Union (EU). The exploitation and dissemination of the as-obtained results expect to generate great benefits for the European research Area and industries, as well as, high socio-economical and environmental impacts on the EU society.

Keywords: crude glycerol to biopropylene,one step hdo reaction,rational catalyst design,time resolved spectroscopy,high throughput gtp optimisation,process intensification
European Social Catalyst Fund (ESCF)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Coordination and support actions
Countries involved: Germany,Ireland,Belgium
Call: A European Social Catalyst Fund to scale up high performing social innovations in the provision of social services (H2020-SC6-GOVERNANCE-2019, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 250000.0
EU funding (EUR): 250000.0
Participants: 3
Project status: CLOSED

As societies evolve and the challenges they face take on old and new form and expression, it is vital that governments and their partners find ways to best serve their citizens. As governments’ management of and impact on the most vulnerable in society is increasingly in the spotlight, innovation in social services delivery is critically needed. This brings into sharp focus why and how a European Social Catalyst Fund (ESCF) can be a key stimulus factor in the delivery of socially innovative initiatives that have the capacity to scale to make a real impact at national and international levels. This proposal intends to establish the ESCF and is based on practical social innovation experience garnered by the Consortium, working with philanthropy and government to bring about sustainable improvements for service users, across a range of social services. The ESCF is designed to bring together public and private resources in a range of collaborations that focuses on the role that philanthropy and social impact finance can play in working with governments to help re-focus public spending in a more cost-effective direction in the interest of EU citizens. Innovations in social services will be identified and supported through the ESCF to develop robust implementation plans to enable scaling. The implementation plans funded from the call will be transferrable across EU countries, subject to tailoring aspects to fit local cultural and operational environments. The Consortium has demonstrated experience of embracing the catalytic role that private finance can play in creating innovations and offers a highly viable route to achieving scale by the public sector. Learnings from this process will be utilised to design a further phase of the ESCF which will focus on supporting the implementation of scaling of innovations.

Keywords: social services,vulnerable people,social investment,philanthopy,social rights,disadvantaged,scaling,social impact,public private collaboration,citizen centred
Clarifying Optimal Sodium Intake Project (COSIP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Ireland
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-10-31
Duration (months): 66.0
Total project cost (EUR): 1499431.0
EU funding (EUR): 1499431.0
Participants: 1
Project status: CLOSED

Hypertension is a leading risk factor for cardiovascular disease (CVD) globally, accounting for 25-35% of the population-attributable fraction. Sodium (salt) intake is a key determinant of blood pressure, and reducing sodium intake has emerged as an important target for population-based interventions to prevent CVD. However, there is considerable uncertainty about the optimal level of sodium (salt) intake that is associated with lowest CVD risk, and whether optimal levels differ for different populations and individuals. In this proposal, we will answer key fundamental research questions about the association of sodium intake with blood pressure and CVD risk. Our research challenges current guideline recommendations of low-sodium intake for all populations. Specifically, we will: a) determine whether sustained (long-term) low sodium intake is associated with beneficial (or adverse) effects on established and novel CV biomarkers. b) explore whether inter-daily ‘pattern’ of sodium intake is an important determinant of 24-hour blood pressure pattern; c) determine whether the association between sodium intake and CVD varies by ethnicity, sex, age, other dietary factors (e.g. potassium intake), or other factors in 2 large international epidemiologic studies (PURE and INTERSTROKE; n>125,000 individuals). d) quantify the population-attributable fraction of excess sodium intake on global burden of CVD (stroke, myocardial infarction, heart failure and CV death), and model the potential impact of various population-based approaches to reducing sodium intake; e) determine whether sodium intake is associated with other vascular-related clinical conditions, namely including atrial fibrillation, cognitive impairment and falls (providing novel information); f) determine whether genetic variants associated with ‘salt sensitivity’ and hypertension are association with blood pressure and stroke, and whether these associations are modified by sodium intake.

Keywords: dietary intake
Super Exotic NUClear systems at the limit of stability: Core excitations in halo nuclei and few-nucleon emitters. (SENUC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

SENUC is a project aiming at improving our knowledge of the structure and dynamics of Super Exotic NUClear systems at the limit of stability, focusing on the properties of halo nuclei and few-nucleon emitters, through the development of innovative coupled-channel models including core excitations within both collective and microscopic approaches and their implementation in novel computer codes that will be made publicly available. This action will be developed by integrating the researcher in the renowned Nuclear Physics group of the University of Seville, with a strong interest on the theoretical interpretation of recent and new experiments at Radioactive Ion Beam (RIB) facilities in Europe and worldwide. The research objectives are focused on: 1) the description of core correlation effects in processes involving super exotic nuclear systems, and 2) bridging the gap between few-body collective models and the microscopic many-body structure of nuclei at the dripline boundaries and beyond. A proper knowledge of these topics is crucial to assess how shell evolution shapes the limits of the nuclear chart, with implications for open questions in Physics regarding the strong force and nucleon-nucleon correlations. Accordingly, SENUC will provide an innovative theoretical framework to support the most recent advances in RIB physics, describing processes induced by or involving the most exotic nuclear systems that are available or will be soon produced in next-generation facilities such as FAIR-GSI, FRIB-MSU or RIBF-RIKEN.

Keywords: nuclear structure,nuclear reactions,exotic nuclei,halo nuclei,few nucleon emitters,3body nuclei,core excitations,correlations and decay,collective and microscopic excitations,coupled channels
Control of T cell differentiation and plasticity through mitochondrial reprogramming (REPROGRAMIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Mitochondria participate during the metabolic reprogramming of naive T cells. However, the molecular mechanisms by which mitochondria regulate T cell differentiation remain elusive. The project aims at revealing the mechanisms behind mitochondrial function and lineage specification and maintenance. Combining high-throughput analysis of gene expression and chromatin epigenetic status with biochemical, metabolic, cellular, and in vivo and in vitro approaches, we want to assess how mitochondria coordinate the metabolic status of the cell to transcriptional and epigenetic changes to control T cell differentiation and function in distinct inflammatory environments. For that our challenges are; (Obj.1) To investigate the role of mitochondrial dynamics in the metabolic reprogramming of T cell differentiation, (Obj.2) To study how metabolic pathways shape the transcriptional and epigenetic networks of the T cell lineages, (Obj.3) To identify mitochondria-to-nucleus signaling pathways that regulate T cell differentiation through modification of the transcriptional and epigenetic landscape, and (Obj.4) To investigate the therapeutic potential of reprogramming mitochondrial function in T cell responses against infection and cancer. REPROGRAMMIT will unveil significant breakthrough on (1) how mitochondria regulate the metabolic profiles of the distinct T cell subsets, (2) the identification of molecular candidates that reverse or modify T cell transcriptional programs through regulation of mitochondrial function, (3) the understanding on how nutrient availability and metabolic intermediates shape T cell differentiation and plasticity. In sum, REPROGRAMIT puts forward an ambitious and multidisciplinary but feasible program with the wide purpose of identifying novel checkpoints based on the crosstalk between mitochondria and the epigenome, with the final goal to modulate T cell immune responses against infection and cancer by reprogramming mitochondrial function.

Keywords: immunometabolism,mitochondria,t cell differentiation,mitochondrial dynamics,oxphos,opa1,plasticity,mitochondria to nucleus signaling,metabolic reprogramming,metabolic competition
Automated computational design of site-targeted repertoires of camelid antibodies (AutoCAb)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 2337500.0
EU funding (EUR): 2337500.0
Participants: 1
Project status: SIGNED

We propose to develop the first high-throughput strategy to design, synthesize, and screen repertoires comprising millions of single-domain camelid antibodies (VHH) that target desired protein surfaces. Each VHH will be individually designed for high stability and target-site affinity. We will leverage recent methods developed by our lab for designing stable, specific, and accurate backbones at interfaces, the advent of massive and affordable custom-DNA oligo synthesis, and machine learning methods to accomplish the following aims: Aim 1: Establish a completely automated computational pipeline that uses Rosetta to design millions of VHHs targeting desired protein surfaces. The variable regions in each design will be encoded in DNA oligo pools, which will be assembled to generate the entire site-targeted repertoire. We will then use high-throughput binding screens followed by deep sequencing to characterize the designs’ target-site affinity and isolate high-affinity binders. Aim 2: Develop an epitope-focusing strategy that designs several variants of a target antigen, each of which encodes dozens of radical surface mutations outside the target site to disrupt potential off-target site binding. The designs will be used to isolate site-targeting binders from repertoires of Aim 1. Each high-throughput screen will provide unprecedented experimental data on target-site affinity in millions of individually designed VHHs. Aim 3: Use machine learning methods to infer combinations of molecular features that distinguish high-affinity binders from non binders. These will be encoded in subsequent designed repertoires, leading to a continuous “learning loop” of methods for high-affinity, site-targeted binding. AutoCAb’s interdisciplinary strategy will thus lead to deeper understanding of and new general methods for designing stable, high-affinity, site-targeted antibodies, potentially revolutionizing binder and inhibitor discovery in basic and applied biomedical research.

Keywords: protein design,antibody design,camelid antibodies,repertoire design,deep sequencing,stability design,diagnostics,inhibitors,affinity design,specificity design,rosetta design
Directed Evolution of Metalloenzymes through Electrochemical Droplet Microarrays (DEMED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-01
End date: 2023-05-19
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 2
Project status: CLOSED

The goal of this Marie Curie Individual fellowship proposal is to establish directed evolution of redox enzymes by means of electrochemical microarrays (DEMED) to enable the direct screening of the enzyme properties desired for their application in electrochemical devices. An O2 reducing metalloenzyme for implementation in biocathodes of H2/O2 enzymatic fuel cells will serve as model system to demonstrate that directed evolution of such redox enzymes screened by electrochemical droplet microarray is advantageous to specifically improve biofuel cell performances. The selected metalloenzyme is rubredoxin: oxygen oxidoreductase (ROO), which has never been applied to H2/O2 enzymatic fuel cells so far. First, ROO gene will be cloned and its random mutagenesis library will be synthesized. Second, the electrochemical droplet microarray will be adapted to enable the screening of the desired properties of the metalloenzyme. Third, electrochemical directed evolution of ROO will be carried out. Finally, the interface of ROO and electrode based on redox active polymers will be co-evolved with ROO to achieve high electron transfer rates to the enzyme and thus enable the fabrication of a high performance biocathode. It is expected that this project will have a groundbreaking on directed evolution of metalloenzymes for their practical implementation in electrochemical devices.

Keywords: directed evolution of enzymes,biofuel cells,oxygen reduction enzyme,electrochemical microarray
Beyond super-resolution: ultra-resolution imaging provides solutions for synapse physiology and brain pathology (ULTRARESOLUTION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Germany,United States
Call: ERC Synergy Grant (ERC-2020-SyG, 2020)
Start date: 2021-06-01
End date: 2027-05-31
Duration (months): 72.0
Total project cost (EUR): 11100221.0
EU funding (EUR): 11100221.0
Participants: 3
Project status: SIGNED

Neurons contain hundreds of specialized proteins, whose topology reflects activity, plasticity and disease. Present imaging techniques are unable to present this topology accurately, since even the best super-resolution tools are limited to at least 20-30 nm, many times the size of individual proteins (~3-7 nm). To solve this problem, our ground-breaking objective is to develop reliable ultra-resolution imaging, with true molecular resolution of 1-5 nm. We will combine optics-based super-resolution with a recent innovation, pioneered by our team – physical expansion of the samples. Our efforts will be aided by several imaging tools we have generated, from super-resolution modalities to nano-affinity probes, which, thanks to their power and ease-of-use, are already employed by hundreds of research groups. We will apply ultra-resolution to reveal the functional organization of key components of the synapse, in health and disease. We will also develop protocols for brain pathology samples, for future use in medical diagnostics. Finally, we will establish simple protocols that will enable the application of ultra-resolution in every biomedical laboratory. Our multidisciplinary group, composed of a synapse physiologist (Rizzoli), a single-molecule imaging chemist (Sauer), and a physics and bio-engineering specialist (Boyden), is optimally placed to address this challenge. All PIs are also super-resolution specialists, with extensive expertise in stimulated emission depletion (STED), direct stochastic optical reconstruction microscopy (dSTORM) and expansion microscopy (ExM), respectively. The vast expertise required by this project implies that none of our groups could pursue it alone, and that no other groups, world-wide, could attempt it. Its successful implementation will provide: 1) imaging technology far beyond the state-of-the-art, which will prove transformative in many branches of biology; 2) solutions to multiple questions on synaptic and brain function.

Keywords: synapse,neuron,imaging,synuclein,resolution,super resolution,expansion microscopy,sted,storm