Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Photoelectrocatalytic device for SUN-driven CO2 conversion into green CHEMicals (SunCoChem)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Spain,Germany,Italy,Germany,Spain,Spain,Greece,Switzerland,France,France,United States,Netherlands
Call: Photocatalytic synthesis (RIA) (H2020-NMBP-ST-IND-2019, 2019)
Start date: 2020-05-01
End date: 2024-04-30
Duration (months): 48.0
Total project cost (EUR): 6810295.0
EU funding (EUR): 6617645.0
Participants: 18
Project status: SIGNED

SunCoChem will have an important impact in reduction of the dependence of the European Chemical Industry (ECI) on carbon feedstock by producing a competitive and integrated solution enabling the carbon-netural production of high valuable chemicals from solar energy, H20 and CO2. SunCoChem will provide a solution based on a competitive tandem photoelectrocatalytic reactor (TPER) to efficiently produce oxo-products from CO2, water and sunlight. This will be achieved by process intensification coupling a sun-driven carbon dioxide reduction to CO/water oxidation to O2 with C-C bond carbonylation reaction catalysed by novel multifunctional hybrid photoelectrocatalysts (PEcats) SunCoChem is focused on the production of 3 main oxo-products of interest for three important chemical industries in Europe: i) Glycolic Acid, used as polymers building block and of interest to AVANTIUM CHEMICALS BV; ii) Valeraldheyde, a flavor ingredient of interest to and produced by DOW CHEMICALS; and iii) LimoxalTM a fragrance ingredient of interest to and produced by IFF. The TPER will be demonstrated at a TRL5 scale of 1m2 and validated by a set of 3 case studies corresponding to the 3 selected products, representing real chemical industry needs from the 3 mentioned industrial partners. The sustainable and efficient technology for oxo-products production will be demonstrated by addressing the recycling CO2 flue gas and by-products from Dow Chemicals and IFF, with an improved chemical energy conversion efficiency (≥10%) and CO2 emissions reduction (≥50%). The advantages of the SunCoChem technology in terms of social and environment impact will be analyzed with respect to conventional production routes of the same target products. Maximum impact will be ensured through the involvement of the mentioned three industrial end users in the validation of the technology, a well-balanced dissemination, standardization, communication, stakeholders engagement and exploitation of the different results.

Keywords: sun light energy to chemicals,artificial photosynthesis,tandem photoelectrochemical reactor,photoelectrocatalysis,selective carbon dioxide reduction,oxygen evolution reaction,carbonylation
ONCOgenic Receptor Network of Excellence and Training (ONCORNET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Spain,Spain,Germany,Switzerland,Belgium,Belgium,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2019-05-31
Duration (months): 53.0
Total project cost (EUR): 3893983.37
EU funding (EUR): 3893983.37
Participants: 16
Project status: CLOSED

Cancer is a leading health concern. There is a need to fully understand the fundamental processes underlying development of cancer. There is increasing evidence that G protein-coupled receptors (GPCRs) and their associated signalling cascades are involved in both cancer progression and metastasis. As oncogenic GPCRs are likely to be amenable to manipulation via drugs they are ideal therapeutic targets. In ONCORNET (Oncogenic Receptor Network of Excellence and Training) we propose to target two oncogenic GPCRs; the chemokine receptors CXCR4 and CXCR7. These are highly expressed in a range of tumours and yet their role in cancer progression is not well understood. We will focus on unravelling how CXCR4 and CXCR7 are or can be modulated (small molecules, pepducins, nanodies) and investigate the effects on oncogenic responses. This represents crucial knowledge that we currently do not have and yet may well provide potential leads for drug development and commercialisation. ONCORNET will bring together the leading research scientists and labs in Europe with an interest in GPCRs and 15 early stage researchers. We will employ all the latest multidisciplinary research technologies to understand the role of these GPCRs in cancer and develop CXCR4 and CXCR7 tools for diagnostic and therapeutic purposes. Importantly, developed approaches can be extrapolated to other oncogenic GPCRs. The ONCORNET consortium will offer an extensive multidisciplinary training programme to the ESRs to ensure that they can operate in today’s drug discovery programmes. This will include both research (e.g. drug discovery, proteomics, imaging, modelling) and transferable (e.g. entrepreneurship, writing, media training) skill sets –that is rarely offered at PhD level. We will train ESRs to develop the next generation of multidisciplinary scientists with skills that are highly demanded by many of today’s employers in drug development industries.

Keywords: g protein coupled receptor,chemokine,oncogenesis,beta arrestin
Children’s Liver Tumour European Research Network (ChiLTERN)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Germany,Germany,Germany,Spain,Ireland,Austria,Spain,Spain,Italy,Italy,Israel,Germany,Switzerland,Belgium,Norway,Poland,Sweden,Finland,France,France,Czechia,Netherlands,United Kingdom,United Kingdom
Call: Establishing effectiveness of health care interventions in the paediatric population (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2021-12-31
Duration (months): 72.0
Total project cost (EUR): 8191665.0
EU funding (EUR): 7941665.0
Participants: 31
Project status: CLOSED

Liver cancer in the paediatric population is rare with an incidence approximately 1-1.5 per million population. The commonest tumour seen in the childhood population is hepatoblastoma (HB), usually seen in young children and infants. Much rarer (about 10% of paediatric liver cancers) is hepatocellular carcinoma (HCC), usually seen in the teenage population and sometimes associated with underlying cirrhotic liver diseases. The ChiLTERN project relates to topic PHC 18 ‘establishing effectiveness of health care interventions in the paediatric population’. The ChiLTERN project builds on a unique opportunity to undertake a comprehensive research programme linked to an ambitious global partnership which will see the single largest clinical trial (the Paediatric Hepatic International Tumour Trial - PHITT) ever undertaken in this population of patients, with several randomised questions in six subgroups of patients. ChiLTERN will allow us to move towards an era of personalised therapy in which each patient will receive the correct amount of chemotherapy and will undergo has the best surgical operation (surgical resection or liver transplant). By using both clinical and biological information, we can assign patients more accurately to risk groups based on their survival. Using genetic tests and biomarkers, we will determine those children who may be at risk of developing long term side effects (deafness, heart failure, kidney damage). In addition, biomarkers will allow us to monitor during therapy and detect toxicities early before serious damage is done so that we can adapt treatment and prevent these problems. Finally, we will be using imaging technology tools which will help our surgeons plan liver operations more safely and effectively. Ultimately ChiLTERN will allow us to cure more children with liver cancer, expose fewer children to toxic chemotherapy and ensure their surgery is both effective and safe.

Keywords: hepatoblastoma,risk stratification,chemotoxicity,biomarker,molecular biology,personalized medicine
Deciphering cell-cell and cell-microbiome interactions of innate lymphoid cells at the single cell level (ILCSIGNALLING)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Israel
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 170509.2
EU funding (EUR): 170509.2
Participants: 1
Project status: CLOSED

Battling acute and chronic enteric disease is a priority in Europe and worldwide, especially now at the age of widespread antibiotic resistance. A network of gut immune and epithelial cells tolerates commensal microbes, while retaining its ability to initiate a potent response upon pathogenic infection. Whether and how commensal gut microbes affect the capacity of immune system to fight enteric infection remains largely unknown. This project aims to reveal how the microbiome modulates immune system focusing on recently discovered, but poorly understood innate lymphoid cells (ILCs). The Researcher will use her expertise in single cell transcriptomics to profile dozens of cell populations from the gut, coupled with computational signalling network reconstruction, to identify and characterise the cell-to-cell interactions of ILCs during infection. Microbial transplants into germ free mice and antibiotic treatments will reveal how microbiome shapes immune response, in particular how it affects inter-cellular communication. This novel systems-level approach will enable major advances in three areas of study: (I) the elucidation of cell-to-cell communication circuits; (II) the integration of ILCs into the network of intestinal immune responses; and (III) the understanding how the resident microbiota impact the host response to infection. Furthermore, this study will contribute with open-access extensive resource of cellular phenotypes and interactions during early anti-pathogen response and will provide a new computational method illustrating how to capitalise on the bounty of single-cell RNAseq data. The project will allow combining the Researcher’s expertise in single cell RNA sequencing with expertise of Elinav lab in the gut host-microbiome interactions, that will lead to bidirectional transfer of knowledge and will help the Researcher to achieve scientific independence needed to assume principle investigator position in the future.

Keywords: microbiome,mucosal immunity,single cell rna sequencing,enteric infection
European Packaging, Assembly and Test Pilot for Manufacturing of Advanced System-in-Package (EuroPAT-MASIP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Austria,Austria,Germany,Germany,Germany,Ireland,Germany,Germany,Germany,Germany,Finland,Finland,Hungary,Finland,Sweden,France,France,France,France,Netherlands,Portugal
Call: ECSEL Key Applications and Essential Technologies (IA) (H2020-ECSEL-2016-2-IA-two-stage, 2016)
Start date: 2017-04-01
End date: 2021-06-30
Duration (months): 51.0
Total project cost (EUR): 29734972.5
EU funding (EUR): 7203644.58
Participants: 28
Project status: CLOSED

na

Keywords: packaging,fowlp,ewlb
Developing CRISPR adaptation platforms for basic and applied research (CRISPRsition)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-12-01
End date: 2025-11-30
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The CRISPR-Cas system has been extensively studied for its ability to cleave DNA. In contrast, studies of the ability of the system to acquire and integrate new DNA from invaders as a form of prokaryotic adaptive immunity, have lagged behind. This delay reflects the extreme enthusiasm surrounding the potential of using the system’s cleavage capabilities as a genome editing tool. However, the enormous potential of the adaptation process can and should arouse a similar degree of enthusiasm. My lab has pioneered studies on the CRISPR adaptation process by establishing new methodologies, and applying them to demonstrate the essential role of the proteins and DNA elements, as well as the molecular mechanisms, operating in this process. In this project, I will establish novel platforms for studying adaptation and develop them into biotechnological applications and research tools. These tools will allow me to identify the first natural and synthetic inhibitors of the adaptation process. This, in turn, will provide genetic tools to control adaptation, as well as advance the understanding of the arms race between bacteria and their invaders. I will also harness the adaptation process as a platform for diversifying genetic elements for phage display, and for extending phage recognition of a wide range of hosts. Lastly, I will provide the first evidence for an association between the CRISPR adaptation system and gene repression. This linkage will form the basis of a molecular scanner and recorder platform that I will develop and that can be used to identify crucial genetic elements in phage genomes as well as novel regulatory circuits in the bacterial genome. Together, my findings will represent a considerable leap in the understanding of CRISPR adaptation with respect to the process, potential applications, and the intriguing evolutionary significance.

Keywords: crispr acquisition,crispr adaptation,molecular recording,bacteria,bacteriophage,directed evolution
innovative solutions for USER centric CHarging Infrastructure (USER-CHI)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Germany,Spain,Germany,Germany,Spain,Italy,Spain,Italy,Spain,Belgium,Finland,Hungary
Call: User centric charging infrastructure (H2020-LC-GV-2019, 2019)
Start date: 2020-02-01
End date: 2024-01-31
Duration (months): 48.0
Total project cost (EUR): 17471618.43
EU funding (EUR): 14263188.38
Participants: 26
Project status: SIGNED

USER-CHI aims at unlocking the massive potential of electromobility in Europe. This will be achieved by (1) integrating different innovative charging technologies with a holistic perspective, (2) putting the user at the centre and empowering it, (3) exploiting the synergies between electromobility and the process of greening and smartification of the grid which is taking place to achieve the energy transition in Europe, (4) integrating the technological tools, business models and regulatory measures which will transform the elements cited above into an actual, working ecosystem which improves the user experience of EV drivers beyond the current levels of ICE vehicles drivers, whilst at the same time makes financially attractive for the relevant private and public actors the large scale deployment of Europe’s required user centric charging infrastructure. USER-CHI will boost a large-scale e-mobility market take up in Europe, by means of developing integrated smart solutions, novel business models and new regulatory framework conditions, which will be demonstrated and validated in 5 urban areas all along the European territory: Barcelona metropolitan area (Spain), Rome (Italy), Berlin (Germany), Budapest (Hungary), and Turku (Finland). These 5 sites act as connecting nodes of the key Mediterranean and Scandinavian-Mediterranean TEN-T corridors, while their different sizes, complementary contexts and e-mobility maturity level offer a holistic view of e-mobility in Europe, facilitating the scalability and replicability of the demonstrated solutions. Since large scale replication and transferability of USER-CHI results is one of the cornerstones of the project, a replication city has been included in each of the TEN-T corridors involved in the project: Murcia (Spain) in Mediterranean corridor and Florence (Italy) in Scandinavian-Mediterranean corridor. This, together with the involvement of EUROCITIES will maximise the project impact even after its completion.

Keywords: electromobility,charging infrastructure,user centric,business models,smart grid,interoperability,ten t corridors
Gamut mapping technology based on vision models (GAMMAVISION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-08-01
End date: 2020-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The color gamut of a display is the set of colors that it can reproduce: screens with wider gamuts are capable of presenting more vivid, intense colors. Different display technologies have different gamuts, from the narrow gamut of TV sets to the wide gamut of cinema and the ultra-wide gamut of laser projectors. Gamut mapping is the process of adapting the colors of an image to the gamut of the display where it is shown, and it is an essential process at every step of the imaging chain: cameras perform automatic gamut reduction, in movie postproduction colorists perform gamut mapping manually, and emerging display technologies perform automatic gamut extension. There is a trade-off between speed and quality, and no method, be it automatic or manual, is exempt from issues. One of the research outcomes of the applicant’s ERC Starting Grant IP4EC is a vision-based gamut mapping method that is automatic, of extremely low computational complexity, and produces images and videos that look natural, without any halos, spurious colors or artifacts. The model has been validated confirming that it outperforms state of the art algorithms in terms of users’ preference. A European patent application has been filed. The core idea for this Proof of Concept proposal is to make a series of products that highlight the capabilities of our gamut mapping method on three distinct scenarios: image and video capture, professional post-production of photography and cinema, and image and video display. Specifically, this project will produce, in a B2C commercial approach, a free web application and commercial mobile apps for iOS and Android systems intended for the general public, plus commercial plug-ins for professional movie and photo post-production software. We will formulate a business plan around these products, that also show the potential of our model for other applications for which we intend to license our technology and provide services, in a B2B commercial approach.

Keywords: visual perception,vision models,color appearance,color enhancement,wide color gamut,image processing,image capture,image display,photography,movie post production
BASAJAUN - Building A SustainAble Joint between rurAl and UrbaN Areas Through Circular And Innovative Wood Construction Value Chains (BASAJAUN)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Innovation actions
Countries involved: Spain,Germany,Spain,Italy,Spain,Spain,Italy,Spain,Belgium,Sweden,Finland,Sweden,Finland,Poland,Finland,Hungary,Sweden,France,France,France,France,Netherlands,Chile,Portugal
Call: Sustainable wood value chains (H2020-RUR-2019-1, 2019)
Start date: 2019-10-01
End date: 2024-03-31
Duration (months): 54.0
Total project cost (EUR): 12287506.91
EU funding (EUR): 9997010.26
Participants: 37
Project status: SIGNED

European rural areas will boost when their natural resources constitute the basis of innovative and sustainable value chains with a high positive economic impact. In this sense, forests constitute an asset that provide not only ecosystems and biodiversity, but also a valuable and sustainable raw material, “wood”. Wood is consumed by various sectors, including one of the most “raw materials” demanding sector, the construction. The BASAJAUN project is a puzzle composed of 1st and 2nd transformation companies, research organizations, associations and public bodies that are focused on maximizing the forest value through its use in wood construction. Its main goal is to optimize the wood forest resources to enable the construction of a medium sized building (16 dwellings with 4 floors) with the lowest possible forest hectares – that will depend on the tree species and the forest local peculiarities (climate, surface, ...). The whole process will be optimised to maximize the consumption of wood products from the forest (solid wood, fibers, veneers, bark, sawdust, etc.). For this purpose, a) innovative wood-based construction materials (thermal insulation, composites, varnishes, SIPs) and systems (structure, facades, floors, walls, roof and fixings) will be developed and upscaled, b) one full-scale demo building (France) will be constructed and one experimental building (Spain) that use all developed products, c) digitalization of the whole construction value chain (from forest to building) will be done and d) the rural development impact will be studied at regional level. The environmental impact of the products of these value chains will be assessed as well. Besides, to assure a sustainable impact of the project a novel thematic platform to integrate the stakeholders of the wood region with urban areas will be developed. Besides, BASAJAUN leverages the previous results of successful projects where the innovative materials and systems were designed at laboratory and semi-industrial scale.

Keywords: rural development,wood construction,environmental assessment,circular economy,upscaling construction materials products,construction systems,demobuildings,digital transformation,open innovation