Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Fostering a Transition towards Responsible Research and Innovation Systems (FoTRRIS)

Framework: Horizon 2020 — Science with and for Society
Programme: Develop the governance for the advancement of responsible research and innovation by all stakeholders, which is sensitive to society needs and demands and promote an ethics framework for research and innovation
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Austria,Belgium,Hungary,Belgium,France
Call: Fostering RRI uptake in current research and innovations systems (H2020-GARRI-2014-1, 2014)
Start date: 2015-10-01
End date: 2018-03-31
Duration (months): 30.0
Total project cost (EUR): 1674500.0
EU funding (EUR): 1674500.0
Participants: 7
Project status: CLOSED

Fostering a Transition towards Responsible Research and Innovation Systems The main objective of FoTRRIS is to develop and introduce new governance practices to foster Responsible Research and Innovation (RRI) policies and methods in research and innovation systems. Since research and innovation systems and practices in different European MS and within different research performing organisations vary, FoTRRIS will consider the implementation of new governance practices in five different MS In order to stress that responsible research and innovation is a collaborative activity from the very beginning—collaboration starts ‘upstream’, from the definition of the problem or challenge, continues with the analysis of the problem, the projection of potential solutions, the design of a research and innovation project that aims at realising a solution, and goes on during its performance and monitoring—FoTRRIS adds the prefix ‘co’ to the acronym RRI. Moreover, because important present-day challenges are (at least partially) of a global nature, but manifest themselves in ways that are influenced by local conditions, FoTRRIS focusses on ‘glocal’ challenges, i.e. local/regional manifestations of global challenges and on ‘local’ opportunities for solving them. FoTRRIS will perform a transition experiment, i.e. an experiment to support the transformation of present-day research and innovation strategies into co-RRI-strategies. It will design, test and validate the organisation, operation and funding of a co-RRI-hub. This hub is conceived as a small organisational unit, that will function as a local one-stop innovation platform that encourages various knowledge actors from science, policy, industry and civil society to co-design, -perform, and –monitor co-RRI-projects that are attuned to local manifestations of global sustainability challenges. The transition experiments performed in 5 member states will be evaluated and policy recommendations to implement co-RRI derived.

Keywords: innovation governance stakeholder involvement grand social challenges sustainable transition societal experiment
Development of high-field DNP-enhanced MAS NMR techniques for structure determination of viral capsids (virus-DNP-NMR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

The atomic-level characterization of large viral particles is one of the greatest challenges of modern structural biology, as well as a fundamental step for the design of effective antiviral treatments. In viruses, the viral genome (double- or single-stranded RNA or DNA) is associated to multiple copies of a capsid protein, forming predominantly icosahedral or helical architectures. These complex superstructures are often studied by X-ray crystallography and electron microscopy (EM). However, only information at low resolution is usually available from EM, and extended and flexible architectures do not provide single crystals amenable to diffraction studies. Over the last years, solid-state NMR (ssNMR) has developed into a powerful structural tool for studying structure and dynamics of solid biological samples at atomic resolution and is now uniquely positioned to complement diffraction-based techniques for the characterization of large functional assemblies. However, proteins of large size or that are available in limited amounts are still inaccessible to site-specific NMR studies. Exploiting a unique equipment available in the host institution, the project aims to remove the current bottlenecks and develop improved dynamic nuclear polarization (DNP)-enhanced ssNMR methodology to push forward the limits of applicability of this technique to macromolecular assemblies, opening new avenues to ssNMR in structural biology. Innovative experimental approaches will be developed to overcome the resolution barriers that currently limit the application of high-field DNP, and new spectroscopic tools will be introduced to allow the structure determination of biomolecules under DNP conditions. The effectiveness and versatility of the newly developed methods will be tested on two viral nucleocapsids of different architectures, the icosahedral capsid of non-tailed bacteriophage AP205 and the filamentous, helical nucleocapsid of Measles virus.

Keywords: solid state nmr,magic angle spinning,dynamic nuclear polarization,structure,dynamics,protein function,virus capsid
Energy and Resource Efficient, Highly Innovative Solution Integrating Punching and Laser Coil Technology for Metal Manufacturing Industry (Efficoil)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The innovative system will be able to interact on a single machine the processes of: (1) punching and forming sheet metal using mechanical tool, and (2) the cutting of sheet metal parts by means of a laser source with fiber of high brilliance. The metal plate being machined on the machine is being fed from coil, which is also loaded on a specific equipment, which composes the plant and allows the end user to work continuously in the sheet metal strip. A mechatronic actuator uses only power required to work to do, no positioning moves made at full power and therefore no waste of energy that becomes heat dissipated into the environment. Also, there are not liquid pollutants such us hydraulic oil or lubrication. - Performance improved for each industrial process High energy savings- up to 50% to standard punching technologies.

Keywords: metal forming,fibre laser,electric punching,metal cutting,resource efficiency,energy saving,coil feeding,process integration,co2 emissions,raw materials
Accelerating Water Circularity in Food and Beverage Industrial Areas around Europe (AccelWater)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Spain,Italy,Iceland,Spain,Iceland,Italy,Germany,Greece,Greece,Greece
Call: Preserving fresh water: recycling industrial waters industry (H2020-LCCI-2020-EASME-singlestage, 2020)
Start date: 2020-11-01
End date: 2025-04-30
Duration (months): 54.0
Total project cost (EUR): 9351000.82
EU funding (EUR): 8115787.38
Participants: 18
Project status: SIGNED

The food and drink industry is the EU's biggest manufacturing. However, this industry is one of the most water and energy intensive industries worldwide while the companies belong to that sector produce a lot of waste. Specifically, the food and beverage industry consumes 56% of the available water for industrial and urban use. Additionally, food processing embeds 28% of the total energy used for production, while the total direct energy consumed by the European food industry amounted to 28.4 Mt oil equivalent, while 30.6 Mt of food waste are produced in this industry. Although, huge steps have been made in increasing the water use efficiency through the use of modern technologies and methods, there is limited effort from the food and beverages industry to minimize freshwater use during the raw material processing. In addition, high water consumption in industrial areas lead to increased production costs due to the fact that the tariffs for public wastewater treatment can be very high in European cities as well as the industrial electricity prices can also be very high. Currently, solutions for wastewater treatment in industries include the use of clarification, membrane filtration, reverse osmosis, process water polishing, disinfection with water treatment chemicals and UV, and biological treatment technologies. However, the use of these technologies under a water-waste-energy nexus is very limited. AccelWater’s project main objective is to optimize freshwater water consumption in the food and beverage industry under a water-waste-energy nexus by introducing beyond state-of-the-art water reclaiming, reusing and Artificial Intelligence enabled monitoring and control technologies will permit the use of reclaimed water in the manufacturing processes of food and beverages and on the same time will allow waste and energy reclamation, optimization and management, and consequently will result to environmental and socioeconomic sustainability.

Keywords: energy recovery,waste valorization,artificial intelligence based seasonal demand and offer prediction,food and beverage industry
Clock Network Services - Design Study (CLONETS-DS)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Germany,Italy,Germany,Poland,Poland,France,France,France,Czechia,Czechia,Netherlands,United Kingdom
Call: Design Studies (H2020-INFRADEV-2019-3, 2019)
Start date: 2020-10-01
End date: 2023-03-31
Duration (months): 30.0
Total project cost (EUR): 2963148.75
EU funding (EUR): 2963148.75
Participants: 20
Project status: SIGNED

The proposed project aims to establish a pan-European time and frequency reference system as a European Research Infrastructure to serve the European science community. It is based on transmitting ultra precise time and frequency information via optical fiber. The proposed project builds on several joint European projects and its direct precursor project CLONETS. We now go far beyond previous efforts by designing a sustainable, pan-European, ultra-precise time-and-frequency reference-system available to the European research community. This Research Infrastructure considers user needs, designs the required architecture, engineering models and roadmaps, and develops a sustainability model for the future service, thus strengthening the European research area. The specific objectives of this project are as follows: 1 Elaborating the needs of the scientific community for ultraprecise timing and frequencies in various fields of research leading to the definition of user requirements the envisaged system has to address in its service at selected points of presence. 2 Defining an architecture that supports this service at the highest, most advanced level of stability and accuracy. 3 Designing an engineering model and strategies to implement a sustainable research infrastructure including the creation of a common data platform. 4 Defining roadmaps and a deployment strategy that assure interoperability of already existing implementations in Europe and possible future extensions. 5 Strengthening the European research area by elaborating plans for the integrations of the necessary environment into the European landscape. In a parallel effort we are planning to list this project in upcoming revisions of the ESFRI roadmap of the EU. This research infrastructure will enable first class research previously not even conceivable, foster the collaboration between time and frequency stakeholders across Europe and will thereby put Europe’s research community into a leading position.

Keywords: time and frequency,optical fiber,optical clocks,fundamental physics,delay stabilization,fiber optics,frequency transfer,time transfer,time and frequency distribution,atomic clocks comparison
attojoule Cryogenic Communication (aCryComm)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Switzerland,Finland,Sweden,Finland,Netherlands
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 3016372.5
EU funding (EUR): 3016372.5
Participants: 7
Project status: SIGNED

The end of Moore’s law has led to unsustainable growth in data centre and high-performance computing (HPC) power consumption. Within the post-CMOS technologies addressing this energy crisis, those based on superconductivity are among the most promising ones. Superconducting classical computing based on single flux quantum (SFQ) pulses is a technology enabling clock speeds exceeding 100 GHz, at extreme power efficiency. Rather than compete with CMOS head on, our vision is that SFQ cores should act as coprocessors in existing HPC architectures, much like GPUs do today. Superconducting circuits are also a leading candidate for implementations of quantum computing (QC), which promises to solve certain classically intractable problems. There, SFQ logic offers a natural solution for tight integration of the signal processing required for control and readout of large-scale error-corrected superconducting quantum processors. In both HPC and QC, expanding to large scale is essential for practical impact, and thus, high-bandwidth data transfer to the cryogenic coprocessor is a key bottleneck. In aCryComm we combine top-level European expertise in HPC, superconducting electronics, quantum computing, and photonics to create an optical data bus between conventional HPC and cryogenic SFQ circuits. We expect the optical data link to outperform conventional electrical connections in bandwidth, energy consumption, thermal loading, and physical footprint. To this end, we will develop opto-electric and electro-optic interfaces, culminating in demonstrators that quantitatively characterize the data bus performance. Thanks to the inter-disciplinary composition of the consortium, we are also able to produce and promote a plan for the long-term exploitation of the cryogenic data bus in HPC and QC. We also suggest paths to commercializing our technologies, taking advantage of the unique possibility the consortium offers for transferring R&D to production in the same European facilities.
SIngle Molecule DEtection and Quantification (SIMDEQ): A new platform for genetic and epigenetic analysis (SIMDEQ)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2014-11-01
End date: 2016-04-30
Duration (months): 18.0
Total project cost (EUR): 148500.0
EU funding (EUR): 148500.0
Participants: 1
Project status: CLOSED

The purpose of the proposed project is to investigate the commercialisation potential of an innovative technology that has been developed in my lab with ERC funding. For over 15 years, our laboratory at the Ecole Normale Supérieure of the Centre Nationale de la Recherche Scientifique (CNRS) has been developing an instrument called a ‘magnetic trap’. Initially developed in order to study the mechanisms of DNA replication and repair, we have discovered in the past few years that this instrument can also be used to extract both genetic and epigenetic information from single molecules of DNA. The highly novel approach we have developed is called SIMDEQTM (short for ‘SIngle-molecule Magnetic DEtection and Quantification’). We have shown that it can be used to rapidly identify, map, quantify, and fully sequence DNA fragments present in a genetic sample. In addition, a unique feature of the technology is that it can detect and locate the naturally-occurring biochemical modifications to DNA’s four bases (e.g. methylation). There is substantial commercial interest in reading these ‘epigenetic’ modifications as they are important in areas such as developmental biology, cancer, and microbial virulence. The SIMDEQTM approach to genetic analysis is simple, elegant, and combines the DNA mapping and sequencing abilities of current instruments with the revolutionary ability to directly detect a wide range of DNA modifications at single base resolution. We believe SIMDEQTM could be a disruptive technology across a wide range of research and diagnostics sectors, but recognize that this is a dynamic field with many competitors and specialized niches. We therefore hope to investigate the market potential of this technology and identify the most promising applications through the work described in this proposal.

Keywords: dna sequencing,epigenetic,single molecule,magnetic tweezers,hybridization sequencing
Regulation of Selective autophagy by sulfide through persulfidation of protein targets. (SSHelectPhagy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-15
End date: 2021-06-14
Duration (months): 24.0
Total project cost (EUR): 175099.2
EU funding (EUR): 175099.2
Participants: 2
Project status: CLOSED

The researcher will address the contribution of sulfide to regulation of selective autophagy in plants through persulfidation. This fellowship will be carried out at Iowa State University under the supervision of Prof. Bassham. The researcher will return to the European host, the University of Seville for 12 months under the supervision of Dr.Gotor at the Institute of Plant Biochemistry and Photosynthesis (IBVF). This project aims at understanding of selective autophagy regulation by sulfide in plants. Autophagy has conserved functions in development, cellular homeostasis, and stress responses from yeast to plants and mammals. In plants, autophagy is critically important in many aspects of plant life, including seedling establishment, plant development, stress resistance, metabolism and reproduction. It contributes to intracellular homeostasis in cells by selectively degrading aggregated proteins, damaged mitochondria, ribosomes, toxic macromolecules, and pathogens to prevent toxicity. This selective autophagy is mediated by the binding of adaptor proteins, which links a cargo targeted for degradation to the autophagosome machinery. An increasing number of targets for selective autophagy under different stress conditions have emerged in recent years, but the underlying mechanisms of their regulation are still so far unknown. Hydrogen sulfide (H2S) acts as an inhibitor of autophagy induced by nutrient deprivation and its mechanism has been proposed to be through persulfidation of specific targets. Several autophagy (ATG)-related proteins have been identified as modified by persulfidation in previous studies. The overall aim of this project is to shed light to the role of sulfide in the regulation of selective autophagy, mainly of mitochondria and ER, through persulfidation, and to broaden the range of plant targets for mitophagy and reticulophagy that are signaled by sulfide.

Keywords: posttranslational modifications,sulfide,persulfidation,autophagy
Theranostic molecular zipper based switchable nanomedicine for overcoming drug resistance (NinZA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-04-15
End date: 2019-04-14
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

This Fellowship will bring an outstanding researcher from Sweden to the UK to gain new scientific and career skills to position him to become a leading independent academic in the interface of chemistry and biology for translational Nanomedicine. The fellow will design a new class of biomimetic zipper nano-architecture, combining an MRI-enabled SPION scaffold with a zip-unzip, temperature and pH-responsive multi-arm polymer to defuse drug resistant cell functions. These approach could greatly benefit the current investigation of new and alternate therapeutic procedures to overcome drug resistance. The fellow will gain advanced training in translational designs of drugs for recognition and treatment of drug resistant system, and in state of the art techniques for studying such system. Combined with the fellow's knowledge of nanoparticles in medicine, he will have a formidable skill set suited to designing nano-architectures for developing target-specific nano-drugs to push back frontiers in the battle against cancer. His excellent track record is in consistent with last two years performance with 4 publications (with cumulative IF>28) with leading publishers including Nature group, Wiley, Cell press etc., 1 cover page and cover story, one Keynote lecture and 2 international research competition awards (FEBS Young scientist forum and Nano Today, Elsevier ST award). A series of complementary career skills trainings will enhance the fellow's research management, leadership, presentation and teaching skills and make him an impressive and exciting candidate for an independent EU academic position.

Keywords: durg resistance,molecular zipper,theranostic,drug delivery,off switchable system