Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Search for a new light scalar particle in the K+→π+χ decay at the NA62 experiment at CERN (NewLightScalar)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-07-03
End date: 2019-07-02
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The Higgs boson was discovered at CERN in 2012 putting the last missing brick into the Standard Model that successfully describes phenomena up to the TeV energies. However, the Standard Model is incomplete offering no explanation for a range of phenomena, which motivates the development of various extensions. Some of these extensions predict the existence of new particles at low energy scale, and can be therefore tested in meson decays. The main aim of this project is to observe physics beyond the Standard Model in kaon decays through the search for a new light scalar particle χ in the decay K+→π+χ, χ→μ+μ- at the NA62 experiment at CERN.

Keywords: kaon decays,physics beyond standard model,light scalar,inflaton,na62
RNAfate- revealing regulation of cellular “noise”. (RNAfate)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

RNA is an essential element in the flow of genetic information in the cell. Recent development of genome-wide techniques reveal multiple novel RNA transcripts, mostly non-coding (nc) for protein. Their significance for the cell is still poorly understood and at first they were considered as “noise”. During the recent decade research has revealed growing evidence for the importance of ncRNAs in cell development and disease. Further elaboration of their functions remains a pressing need in the field. To address this gap in knowledge we will focus on clarifying their regulation. One of key processes modulating levels of RNA in the cell is degradation. Xrn1 is a highly conserved 5’-3’ exoribonuclease that plays an important role in RNA decay. At the Institut Curie the Morillon’s group has discovered that a class of long non-coding (lnc)RNAs is highly sensitive to Xrn1-decay in yeast. The XRN1 sequence is well-conserved from yeast to human, but very little is known about human (h)Xrn1 targets other than mRNAs. Recent studies have revealed involvement of human lncRNAs in cancerogenesis or viral infection. Moreover, studies of Hepatitis C virus (HCV) have shown that viral infection change ncRNA levels. Others have reported that viral structured (sf)RNA can inhibit hXrn1. But how this sfRNA affect ncRNA-om was not yet determined. Importantly, Xrn1 can localize to cytoplasmic foci called P-bodies which are dynamic reservoirs of multiple RNAs and proteins involved in processes such RNA silencing or RNA decay. It has been demonstrated that P-bodies are altered in multiple human diseases and upon viral infection. There are three objectives for this project: 1) identifying novel members of the hXrn1-sensitive coding and noncoding transcriptome, 2) understanding, on a genome-wide scale, how the impairment of hXrn1 by viral sfRNA can change ncRNA stability, as well as their potential role in infection 3) defining the effect of hXrn1 impairment on P-body formation and composition.

Keywords: rna degradation,xrn1,5 3 exoribonuclease,long non coding rna,p bodies
Locomotive bOgie Condition mAinTEnance (LOCATE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Spain,France,France,United Kingdom,Portugal,Portugal
Call: Condition-based and preventive maintenance for locomotive bogie (H2020-S2RJU-OC-2019, 2019)
Start date: 2019-11-01
End date: 2022-04-30
Duration (months): 30.0
Total project cost (EUR): 1499072.5
EU funding (EUR): 1499072.5
Participants: 6
Project status: SIGNED

The LOCATE project will develop a set of tools to access the condition of freight locomotive bogies to imple-ment a condition based maintenance program. It is the goal of LOCATE to contribute to an optimization of the availability of rolling stock, the quality of service, maintenance costs and return of investment. The LOCATE project consortium is composed by 6 entities from 4 different countries, namely: - EVOLEO Technologies: SME dedicated to the development of critical electronic systems; - IST Instituto Superior Técnico: University and Research Centre - University of Huddersfield: University and Research Centre - FGC Ferrocarrils de la Generalitat de Catalunya: Railway Operator, Railway Infrastructure Manager, Railway Entity in charge of Maintenance, Research - UIC International Union of Railways: International Association of Railways Operators and Infrastruc-ture Managers - VIBRATEC: SME dedicated to sensing technologies.

Keywords: predictive maintenance,condition based maintenance,freight railway,bogie,locomotive,rams
Business Opportunities in Biotech: Innovation Associate to leverage cell-free synthetic biology (BOB)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany
Call: European SME innovation Associate - pilot (H2020-INNOSUP-2019-02, 2019)
Start date: 2019-09-15
End date: 2020-09-14
Duration (months): 12.0
Total project cost (EUR): 121050.0
EU funding (EUR): 121050.0
Participants: 1
Project status: CLOSED

The main objective of BOB is to hire and integrate a highly-committed candidate to build up an innovation strategy at c-LEcta to valorize its unique technology platform by developing an innovation project according to the company strategy to become a food ingredient producer. The envisaged innovation will help to solve the industrial problem of natural product synthesis, which is today hampered by yield limits, inefficiencies in chemical synthesis, or side-effects. The functional potential of numerous natural products can only be fully exploited if the commercial production at low cost is possible. Synthetic biology is expected to achieve a break-through for increased or cheaper production. c-LEcta has conceptualized a unique technology platform, already demonstrated the concept’s feasibility, and is targeting new molecules for further growth. However, the innovation team currently lacks of a candidate that comprises excellent technology knowledge in industrial biotechnology and/or food science and innovation management or business administration skills for assessing market values at an early development stage. The German job market is currently marked by a lack of expert personnel, and c-LEcta is experiencing difficulties in receiving high-quality responses to such a position, as it is not visible enough to job-seekers. This will be overcome by a targeted international publication of the vacancy on EURAXESS and beyond. After acquisition of a suitable candidate according to the defined profile, the specific objectives of BOB are: 1) to train the Associate according to a dedicated initiation and advanced training plan (according to the specific needs of the candidate); 2) to identify and assess new target products; and 3) to turn this assessment into an innovation idea and a strategy, deriving at least 1 innovation project. Finally, the Innovation Associate is expected to stay with the company and to strengthen the Innovation and Business development team.

Keywords: synthetic cell free biology,natural products
Cell-cell interactions critical to ILC3 function in the human gut (GutILC3)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

Inflammatory bowel disease (IBD), conferring a dramatically increased risk for development of colorectal cancer (CRC), results from an inappropriate inflammatory response to intestinal microbes in a genetically susceptible host. However, the exact etiology of IBD is unknown. Building up on high impact papers from the host group reporting on the recently discovered innate lymphoid cells (ILCs) as key players in mucosal inflammation, I now aim to unravel the role for ILCs in IBD and CRC. Interestingly, while the IL-22 producing ILC3 seem to be crucial in maintaining intestinal homeostasis, the IL-17 and IFN-gamma-producing ILCs can cause inflammation in a mouse model of colitis and are present in human IBD. Furthermore, ILCs were recently described to be involved in modulating immune responses, by interacting with CD4+ T cells and mononuclear phagocytes in the mouse intestine. I aim to identify critical pathways in the crosstalk of ILC3 with other immune cells in the human intestine. The ultimate purpose is to assess how these interactions affect immune homeostasis and disease progression in IBD and CRC. We will pinpoint crucial interaction molecules and cellular processes that can be used for monitoring current therapies as well as finding new therapy targets for IBD and CRC. This truly translational proposal utilizes, in an optimal manner, unique state-of-the-art techniques and patient materials to provide novel insights into the etiology of IBD and CRC. The excellent track record of the hosting group, the highly suitable infrastructure provided by the host institution and my own extensive research experience ensures a high degree of feasibility. Furthermore, this project provides excellent training opportunities, skill advancement possibilities and career prospects for me and its results are expected to have a direct impact on the European society.

Keywords: innate lymphoid cells,intestinal homeostasis,intestinal inflammation,interaction molecules
Quantitative analysis of variability and robustness in spatial pattern formation (SPACEVAR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 1499883.0
EU funding (EUR): 1499883.0
Participants: 1
Project status: CLOSED

During embryonic development a single cell turns into a complex organism. This process is characterized by an antagonism between variation and stability. On the one hand, development is a tightly controlled process; tissues need to be specified at the right time, at the correct spatial position, and with a defined size. On the other hand, regulation should not be too rigid, since embryos need to adjust to environmental perturbations and correct errors caused by noisy gene expression. We will study variation and stability during pattern formation in the zebrafish heart. We seek to understand the origin of embryo-to-embryo variability as well as robustness against perturbation. The zebrafish heart is a powerful model system for studying variability, since heart positioning is inverted along the left/right axis in 5-10% of wildtype embryos. We aim to identify the mechanism underlying variability in heart positioning and understand its function. To this end, we will combine two innovative approaches: Tomo-seq, a novel method for spatially-resolved transcriptomics developed by the applicant; and single-molecule FISH, a technique that allows absolute quantification of gene expression in single cells. To expand our study of embryo-to-embryo variability beyond gene expression analysis, we will optimize a method for massively parallel single-cell lineage tracing based on CRISPR-Cas. This novel approach will allow us to study embryo-to-embryo variability in developmental lineage specification on the single cell level. We will use this strategy to systematically explore the corrective capacity of the zebrafish heart upon perturbation of progenitor cell pools, and to determine which mechanisms for error correction are activated in the embryo. These quantitative experiments will provide unprecedented insight into variability and robustness during development. The concepts developed here will also be relevant for improving our understanding of variable outcomes in human disease.

Keywords: zebrafish,heart development,quantitative developmental biology,variability and robustness,single cell biology
Hybrid UAV-UGV for Efficient Relocation of Vessels (HUUVER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Innovation actions
Countries involved: Spain,Austria,Austria,Finland,Poland,Poland,Czechia
Call: EGNSS applications fostering digitisation (H2020-SPACE-EGNSS-2019, 2019)
Start date: 2019-12-01
End date: 2022-01-31
Duration (months): 26.0
Total project cost (EUR): 1622987.5
EU funding (EUR): 1197216.25
Participants: 7
Project status: CLOSED

The project HUUVER - Hybrid UAV-UGV for Efficient Relocation of Vessels will result with a prototype UAV-UGV platform that combines two types of propulsion systems. This patented technical solution will activate flying and driving capabilities in one compact and highly integrated autonomous drone. The HUUVER drone will be the first fully integrated with the Galileo navigation system that provides the authentication service and precise navigation and will be fundamental in the navigation system. The positioning accuracy shall be achieved with the sensor fusion system based on multi-constellation satellite navigation system, inertial data and ranging information. The dual-frequency Galileo signals on the E1 and E5b bands will be used for correction of the ionospheric error, will also protect against malitious attacs. The credibility of the provided Galileo positioning will be assured by the new Open Service Navigation Message Authentication. The motivation of the presented product takes its origin directly from the user perspective and expectations, where the flexibility, reliability, extended range are among the most mentioned. Completing for interfacing with an end-user, the HUUVER system will also include a core management system with features like mission planning navigation, guidance and control. A complementary part of the system will be an end-user mobile application enabling mission demand, launch control. The HUUVER platform is expected to be successful in professional missions for search & rescue, patroling & monitoring and industrial logistics. The solution will be tested by end users during the project realization.

Keywords: gnss,galileo,egnos,drivingandflying drone
WEaning practices in ANcient ITaly: from Neolithic farmers to the first cities (WEAN-IT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-04-01
End date: 2022-09-07
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Weaning age directly reflects the way infants are cared for within a human society. It is linked to female fertility, maternal and non-maternal care strategies, social stratification, infant growth and even adult heath. Yet, we know almost nothing about the way weaning age developed during recent human evolution. This project focuses on a critical period in human evolution in Italy that led to major socio-economic changes as Neolithic farming economies gave way to the first cities. The goal in this project is to reconstruct weaning age in extensive collections of human skeletons that span these periods of transitions. I will integrate microstructural, histological and chemical signals of weaning in bones and teeth. Using recently developed cutting edge methodology I will determine for the first time if weaning age differed between the sexes. I will use this information to re-assess existing ideas and hypotheses about the biocultural consequences accompanying the Neolithic revolution and the origins of urbanism to bring a new understanding to this debate. This project adds value and competitiveness to the bioarchaeological research landscape in Europe, thanks to its innovative multi-methodological approach. Not only will my project be of interest to a broad range of academics within the social sciences but it can inform present day public health policy as I will directly measure the effect of weaning on bone growth. Results will be published in high-impact scientific journals and presented at international conferences. Particular attention will be dedicated to dissemination through the media to reach a broader non-academic audience.

Keywords: weaning,neolithic transition,urbanism,diet and growth,dental histology,bone histology,enamel elemental composition
VISION for RETAIL (V4RETAIL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Türkiye
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

One of the major pain points in retail is the lack of speed and precision in information from the selling floor. Acquiring accurate and real-time feedback on inventory distortions, such as out-of-stock, overstock and misplaced items is of paramount importance for all retail operations. This has been pinpointed as an $800 billion global problem for wholesalers, market researchers and retailers. The current practice of supermarket shelf monitoring and auditing relies on the visual inspection of supermarket shelves by a human auditor. This visual inspection mainly involves recognizing packaged products displayed on the shelf and producing an approximate shelf share value for each. The main concept of our innovative solution is to transfer this visual recognition task performed by the auditor to our computer vision based visual recognition software service, which can produce much more accurate and much more detailed counts using a few digital pictures of the supermarket shelf. We think such a service will ease many of the labour intensive problems in retail auditing and consequently be extremely beneficial for our target customers consisting of wholesalers, market research companies and retailers. We have already developed a prototype system for computer vision based automated supermarket shelf monitoring and has tested this prototype in a pilot study carried out jointly with an international market research company. We have therefore shown the technical feasibility of the innovation. At the current stage, we aim at carrying out a feasibility study with two-fold objectives: (1) An extensive analysis of the target markets, (2) A concurrent scalability analysis of the solution in terms of operational and financial aspects. These two objectives will lead to an elaborate business plan for scaling the innovation.

Keywords: retail analytics,retail auditing,stock monitoring,shelf monitoring,inventory tracking,computer vision,pattern recognition,data mining
Wind Energy Generator Onshore and Offshore Inspector (WEGOOI)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-05-01
End date: 2021-01-31
Duration (months): 45.0
Total project cost (EUR): 1104550.0
EU funding (EUR): 773185.0
Participants: 1
Project status: CLOSED

Alerion Technologies commercialises turnkey data solutions for extreme environments through proprietary RPAS that are autonomous and intelligent. After a Feasibility Study, Alerion has decided to focus on windmill inspection market, due to its high barrier of entry, and geographical proximity to important customers that can accelerate international growth. According to the EWEA windmill operations and maintenance represents 30% of the cost of windpark project, and NREL (U.S. Department of Energy) estimates cost of windmill inspections €22K/ MW for onshore and €67K/ MW offshore. Nowadays, most windmill inspection tasks are performed using high-rise equipment and specially trained altitude workers. These solutions are expensive, time consuming, and inefficient for most cases, while effective autonomous and automatic damage identification tool such as an RPAS is a highly desirable solution across the industry. Alerion has estimated that the potential market for autonomous windmill inspection with RPAS is currently €830M annually, with expected growth to €2.6B by 2025. The WEGOOI systems developed by Alerion Technologies will allow customers to drastically reduce windmill infrastructure inspection costs, increase damage assessment effectiveness, and eliminate health risks. This platform is especially suited for structures of difficult access such as windmills, and the company will adapt its technology to fit the exact needs of this market. Alerion has been testing its technological developments in windparks maintained by a multinational company and service provider, and it has already validated Alerion’s prototype RPAS, for its windmill inspections. The prototype version of WEGOOI is at TRL6, capable of inspecting one blade at a time and analysing images in a ground computer. The main goal of WEGOOI is to adapt the existing platform to inspect three blades in one flight and analyse images on-board in real time, and industrialise and commercialise the solution.

Keywords: rpas,windmill,inspection,maintenance,wind energy,automatisation,image processing,artificial intelligence,autonomous navigation