Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Combined AI and Data Solutions for Large Scale Resource Optimization with Green Deal Impact (COSMIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Belgium,Austria,Portugal,Spain,Germany,Poland,Finland,Sweden,France,Ireland
Call: Industrial leadership in AI, Data and Robotics boosting competitiveness and the green transition (AI Data and Robotics Partnership) (IA)[[https://www.europarl.europa.eu/RegData/etudes/STUD/2021/662906/IPOL_STU(2021)662906_EN.pdf]] (HORIZON-CL4-2024-DIGITAL-EMERGING-01, 2024)
Start date: 2024-12-01
End date: 2027-11-30
Duration (months): 36.0
Total project cost (EUR): 10801484.46
EU funding (EUR): 9999846.75
Participants: 24
Project status: SIGNED

With the objectives of the Green Deal in mind, COSMIC aims to provide IT systems that address large-scale energy resource optimization challenges by leveraging AI and data solutions. It will foster collaboration between small and large companies to create industrial ecosystems, focused on key applications with the potential for substantial and escalable impact. COSMIC´s ecosystems are composed by 1) large-industries - facilitating big datasets and large-scale pilots, 2) core technical partners - providing transversal-to-sector technical solutions, 3) SMEs and start-ups – bringing specific data/AI based assets through open calls. The project will offer a set of data/AI based platforms, solutions and modules as transversal core infrastructures able to accommodate external IT assets. Third Parties, mainly SMEs and start-ups, will bring these assets in the form of data/AI based services and solutions, that are specific-to an energy resources optimization key applications. The integration of these core and application-oriented technologies will result in a set of Integrated AI Systems (IAIS) for Key Energy Resource Optimization Applications capable to scale-up to cover more key applications. COSMIC will test these systems in 14 large-scale pilots in 5 countries: Spain, Belgium, Portugal, France and Finland, and at European level, together with the validation of end-user and final beneficiaries' acceptance of social-science methods. To foster replicability, a package will be offer including the lessons learned and recommendations for future adoption, including suggestions for feasible win-win industrial partnerships, and guidance on ecosystems sustainability. These ambitious objectives will be realized by a consortium of experienced and highly complementary partners from both research institutions, industrial partners, public authorities and NGOs from eight European countries.

Keywords: industrial ecosystems,ai based services for the green deal,industry key applications,replicable sustainable industry
Unravelling the formation of Mesozoic bonebeds using rare earth element geochemistry of bioapatites integrated with in-situ dating (MORBID)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-03
End date: 2027-11-02
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Fossil bonebeds are unique windows into ancient ecosystems and the biology of extinct vertebrate species. However, most existing datasets from bonebeds are collected in a qualitative manner and cannot differentiate efficiently between the various biological and geological processes responsible for bonebed formation. MORBID aims to solve this conundrum, by developing a cutting-edge geochemical toolkit focusing on determining the concentrations of rare earth elements within well-preserved bone and tooth material from Mesozoic bonebeds. This rapid in-situ workflow combines non-destructive micro-X-ray fluorescence element mapping with quantitative Laser Ablation ICP-MS profiling at a micrometer level spatial resolution. Bonebed material is selected based on varying geological age and palaeoenvironment and the presence of outstanding taphonomic and paleobiological questions. Once fossilized, bone and teeth retain a geochemical fingerprint of their early diagenetic conditions. This information will be used in MORBID to differentiate between a rapid burial or a reworked bone assemblage, to characterize the depositional environment, and to provenance fossils of unknown location and stratigraphy. In addition, innovative in-situ uranium-lead geochronology is applied on well-preserved bioapatite material to obtain minimum depositional ages of poorly age-constrained fossil strata. MORBID will be based at the Natural History Museum in London and will benefit from the ample experience in-house in dinosaur palaeontology and rare earth element applications, combined with the access to a world-class fossil reptile collection and state-of-the-art laser ablation ICP-MS facilities. This excellent working environment will lead to the development of an independent tool to disentangle post-mortem alteration effects versus potential behavioural components of fossil vertebrates in a critical period of their evolution.

Keywords: palaeontology,taphonomy,geochemistry,bonebed,dinosaurs,bioapatite,fossil bone,fossil teeth,ree,u pb dating,la icp ms,xrf,mesozoic,triassic,jurassic,cretaceous
Single-Cell Metabolomics for Drug Discovery and Development (METADRUG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2022-11-01
End date: 2024-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Despite the major efforts in the modern drug discovery and development, the field is still in its crisis with the productivity increasingly declining. A major source of drug development failure is the toxicity where the adverse drug reaction is often caused by off-target effects of drug candidates that can be revealed only late in the drug development process. Metabolomics was proposed as an emerging promising approach to monitor off-targets effects on metabolic enzymes or transporters thus providing mechanistic understanding of drug toxicity. However, there are multiple challenges in applying metabolomics in this context including the inability to resolve the drug metabolic response on the single-cell level. In this PoC project, we propose to commercialize the technology of single-cell metabolomics developed in the ERC CoG project METACELL. Specifically, we propose using our single-cell metabolomics technology in conjunction with the data-driven metabolic modulation approach for revealing single-cell metabolic response and metabolic mode of action of drugs and drug candidates.
Reconstructing Scribal Vernacular Practices. Coptic Correspondence and Vernacular Scribal Practices in Late Antique and Early Islamic Egypt. (RSVP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-05-01
End date: 2031-04-30
Duration (months): 60.0
Total project cost (EUR): 1499945.0
EU funding (EUR): 1499945.0
Participants: 1
Project status: SIGNED

RSVP aims at reassembling the rich world of scribal practices in Coptic letter writing between the 4th and 11th centuries CE. It offers an ambitious reconstruction of epistolographers’ habits, networks, and cultural identities when Coptic was the vernacular Egyptian language employed alongside official idioms (Greek and Arabic). Using a multidisciplinary approach combining paleography, digital humanities, and sociolinguistic analysis, RSVP will analyze for the first time a corpus of over 5000 Coptic letters along four axes: 1) Challenge established views on vernacular practices through expanded Coptic letter analysis. 2) Investigate literacy, paleography, and writing practices in relation to cultural and linguistic shifts. 3) Identify dialectal variation and code switching through linguistic analysis, illuminating the period’s complex linguistic landscape. 4) Assess published Coptic letters’ impact on social cohesion and power dynamics on a diachronic and countrywide scale. RSVP will contribute to papyrology, Coptology, and digital humanities, by reassessing writing culture, multilingualism, and epistolary étiquette, while applying digital approaches for large-scale analysis of ancient documents and open-linked data (e.g. OCR for semi-automatic text encoding and digital paleography for handwriting identification). Social historians of Antiquity and early medieval times will also have access to a nuanced understanding of cultural continuity and change during a crucial period of political and cultural transition between Byzantium and Islam, enhancing understanding of provincial life, local elites, villagers, and women’s roles. By reconstructing letter-writing practices in Coptic, RSVP will refocus scholarship on overlooked historical sources, shedding new light on epistolographers’ daily matters, cultural identities, and social networks, while providing a view from below. It will amplify long-silenced and forgotten voices.

Keywords: coptic letters,papyrology,ancient literacy,multilingualism,epistolary practices,vernacular language
Streamlining Clinical Applicability of Ultrasound Localization Microscopy via Advanced Reconstruction Models (ULMARM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-02
End date: 2027-06-01
Duration (months): 24.0
Total project cost (EUR): 217076.16
EU funding (EUR): 217076.16
Participants: 2
Project status: SIGNED

The ULMARM, or Ultrasound Localization Microscopy with Advanced Reconstruction Models, seeks to improve ultrasound imaging by addressing key challenges in Ultrasound Localization Microscopy (ULM). Traditional ULM methods require long acquisition times and ultra high frame rates to track microbubbles (MBs) accurately, stretching the capabilities of current clinical ultrasound systems. ULMARM aims to solve these challenges by developing advanced reconstruction techniques and integrating deep learning (DL) models. The goal is to relax frame rate demands while maintaining high-quality super-resolved imaging and accurate motion tracking, making ULM more feasible for clinical applications. In ULMARM, I propose recasting ULM as a mathematical inverse problem to achieve super-resolution in both space and time jointly. By treating the relationship between MB movement and ultrasound frames as a generative forward model, I will infer the most probable MB trajectories from observations using a Bayesian posterior maximization approach. To tackle inherent challenges, I will utilize advanced deep generative models and strong data-driven priors to streamline the inference process. The ULMARM project is organized into six work packages (WPs). WP1 focuses on new sparse coding methods to relax frame rate while preserving image quality. WP2 develops mathematical models for direct reconstruction, including motion compensation for improved accuracy. WP3 uses DL to reconstruct missing data, improving both spatial and temporal resolution. WP4 extends these methods to 3D ULM, tackling challenges like high volume rates and out-of-plane motion. WP5 focuses on evaluating these techniques with experimental and clinical datasets. WP6 handles project management and training. The MSCA Fellowship will provide crucial resources and collaboration opportunities, helping me advance my research in ULMARM, establish innovative techniques to improve ULM’s clinical use, and career development.

Keywords: medical imaging,ultrasound,ultrasound localization microscopy,super resolution,bayesian framework,inverse problem solving,generative ai,frame rate,interpolation
Mass spectrometry assisted sustainable green approaches for food safety and authenticity (PlasMOF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: CLOSED

The agri-food chain from the original product to its commercialization has thorough controls. Authenticity and food safety are highly supported by protocols and are legislated by different organizations. PlasMOF aims to propose novel cutting-edge solutions based on state-of-the-art mass spectrometry (MS) and novel design materials. The use of novel ionization methods based on dielectric barrier ionization (DBDI) and green sample preparation techniques enhanced by using Metal-Organic Frameworks (MOFs) may provide unprecedented advantages in solving relevant food quality and safety. This project proposes novel approaches based on the synergic use of advanced materials and ambient mass spectrometry for some of the challenges that need to be addressed in the agri-food sector related to their quality, authenticity and safety. PlasMOF proposed the synthesis, characterization and application of Metal-Organic Frameworks (MOFs) as novel sorbent materials in miniaturized solid-phase schemes (µSPE). In a second stage, the elaboration of novel devices based on MOFs and their combination with DBD-based ambient ionization methods for relevant societal applications. Different DBD-based tools configurations will be tested as ionization methods in food authenticity (including two-ring electrode DBDI, flexible microtube plasma (FµTP), active capillary sampling plasma source (ACaPI) and low-temperature plasma (LTP)). These novel technologies will be implemented for the assessment of virgin olive oil VOO authenticity and to detect frauds in VOO and in other food products such as wine.

Keywords: dielectric barrier discharge metal organic frameworks agri food
Clonal dynamics and mitochondrial dysfunction in hematopoiesis following chemotherapy (CYNAMIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-12-01
End date: 2026-11-30
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

Chemotherapy can cause significant damage to healthy tissues, especially in the hematopoietic system. As a result, cancer survivors may experience bone marrow damage manifested as cytopenias, which increase the risk of infections and bleeding. Despite this, there has not been a thorough examination of these events, including the clonal dynamics of hematopoiesis after chemotherapy exposure, due to a lack of methodologies to perform lineage tracing in humans in vivo. To address this, I will study the effects of chemotherapy on the clonal dynamics of hematopoiesis, mitochondrial dysfunction and genetic integrity in young cancer survivors. I will analyze samples obtained before, during, and after treatment using emerging single-cell multi-omic approaches to effectively capture mitochondrial DNA (mtDNA) genetic variation for inferences of clonal dynamics and studies of mtDNA damage. By combining mtDNA-based clonal inferences with whole-genome sequencing (WGS)-based detection of somatic nuclear DNA mutations, I will provide deep phylogenies with scalable single-cell resolved clonal measurements of perturbed hematopoiesis following chemotherapy. Moreover, orthogonal analysis of DNA methylation and chromatin accessibility data will yield new molecular insights into chemotherapy-induced accelerated aging and mitochondrial dysfunction (a hallmark of aging). This project sets out to gain quantitative and fundamental insights into the long-term molecular defects of chemotherapy in young cancer survivors, potentially paving the way for new interventions to improve the quality of life of this emergent population.

Keywords: hematopoiesis,clonal dynamics,chemotherapy,mitochondrial genetics,genomics
Terahertz high resolution spectroscopy using driven optical resonators (TRESOR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: SIGNED

Spectroscopy is an important tool to understand molecular and atomic phenomena. Dual comb spectroscopy DCS and asynchronous optical sampling AOSPS are prominent techniques in infrared and Terahertz range respectively. Both rely on dual frequency combs or dual (FC), and their limitations stem from the comb design, necessitating a trade-off between speed and resolution. The spectral resolution is limited by the repetition rate of the FC. The most common sources for FC are mode-locked lasers and electro-optic modulators. However, due to technical peculiarities, these techniques are not suited for low repetition rates, leading most spectroscopy systems in the 100 MHz-10GHz range. TRESOR (Terahertz high resolution spectroscopy using driven optical resonators) aims to showcase a novel optical platform based on ultrashort pulses in low repetition rate, high-Q resonator, to address the limitations inherent in FC based spectroscopy methods. On the fundamental front, I will investigate the generation of novel soliton formations, such as super cavity solitons SCS in high intrinsic loss resonator with large detuning. So far, SCS in low repetition rate resonators have not been experimentally explored, mainly because of the lack of a sufficiently precise perturbation. To use the FC based on SCS in the THz range, pulses need to be amplified. This will give rise to a new challenge related to sub-200fs pulse amplification. On the applied side, by using FC based on SCS, TRESOR can improve the resolution and speed of current spectroscopy methods and give rise to new nonlinear measurement techniques. Despite these fundamental and applied reasons, the experimental approach of TRESOR will overcome such challenges and enable the realization of high-resolution spectroscopy in the THz range with performance beyond the state of art. This project is a step forward in my career because it will act as a springboard towards a permanent research position and will allow me to lead a research group

Keywords: cavity solitons dual comb spectroscopy kerr resonators
A Disruptively New Approach to Weed Management Shaping the Future of Sustainable Agriculture (Agri-Think Robot)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 2429132.25
EU funding (EUR): 1700392.0
Participants: 1
Project status: CLOSED

Odd.bot is a technology start-up in the Netherlands creating the first 100% environmentally friendly, autonomous weed management robot in the world. The solar powered Agri-Think Robot is able to recognise weeds in various growth stages and remove them mechanically between crops. The cutting-edge AI computer vision and unique gripper technology developed by the team allow cost efficient operation with minimal impact to the environment as no pesticides are used. By 2023 Odd.bot will have further increased the precision and capacity of the robot, performing removal at 1 mm accuracy while driving 360 m/h. Farmers will have access to the Weeding-as-a-Service solution through strategic partners without need for capital investment. Soil and water pollution caused by herbicides is avoided, e.g. 10Ha of land will avoid using 240 litres of herbicides yearly. Operating autonomously, the solution is advantageous to both organic and conventional farmers, reducing the need for labour and chemicals.

Keywords: environmental and green technologies,precise agriculture,agri robotics,smart detection system
A Fibroblast-Targeting Advanced Lead Mitigating Inflammation and Fibrosis in IBD (FIBROLEAD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Greece
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-08-01
End date: 2027-01-31
Duration (months): 18.0
Total project cost (EUR): 214285.71
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Inflammatory bowel disease (IBD), which comprises Crohn's disease (CD) and ulcerative colitis (UC), is a growing global health challenge affecting over 6.8 million people. Characterized by chronic inflammation leading to intestinal fibrosis, IBD significantly reduces quality of life and increases the risk of severe complications, including colon cancer. Current treatments primarily target inflammation, and fail to address the persistent activation of inflammatory fibroblast phenotypes and the resulting fibrosis, contributing to frequent relapses and a heightened risk of disease progression. To address this gap, FIBROLEAD introduces a pioneering approach by targeting fibroblasts, key mediators of chronic inflammation and fibrosis in IBD. Our recent research identified VM-313 to effectively disrupt pathogenic fibroblast activation. We now have evidence that this compound has a strong potential in mitigating both inflammation and fibrosis in vitro, ex vivo and in a mouse model of lung fibrosis. Additionally, it exhibits a favourable safety/toxicity profile and drug-like properties that are equal or superior to currently available anti-fibrotic drugs. These findings position VM-313 as a promising candidate for expanding and improving therapeutic strategies for IBD and other fibrotic diseases. This PoC project aims to develop VM-313 as an advanced lead and validate its clinical and commercial potential. Our approach includes assessing its in vivo safety and efficacy in animal models of IBD and determining its mode of action via target identification and validation studies. In parallel, we will develop a comprehensive business case, engage with key stakeholders, and conduct a commercial assessment to evaluate market entry potential. By leveraging our unique targeting strategy and the advantages of a non-invasive oral therapy, VM-313 has the potential to transform IBD treatment, delivering significant benefits to patients.