Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SUstainable and Resilient agriculture for food and non-food systems (FACCE SURPLUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: ERA-NET Cofund
Partnership: FACCE SURPLUS (ERA-NET)
Countries involved: Germany,Estonia,Italy,Spain,Germany,Cyprus,Norway,Belgium,Finland,Poland,Romania,France,France,Netherlands,Denmark,Denmark,United Kingdom
Call: Sustainable and resilient agriculture for food and non-food systems (H2020-ISIB-2014-1, 2014)
Start date: 2015-03-01
End date: 2020-02-29
Duration (months): 60.0
Total project cost (EUR): 15151515.1
EU funding (EUR): 5000000.0
Participants: 26
Project status: CLOSED

The objective of FACCE SURPLUS is to strengthen the European Research Area in support of different integrated food and non-food biomass production and transformation systems, especially by organising, implementing and cofunding with the EU a joint call for transnational research projects on the topic of sustainable and resilient agriculture. As this topic falls within the scope of the Strategic Research Agenda (SRA) of the Joint Programming Initiative on Agriculture, Food Security and Climate Change (FACCE–JPI), this ERA-NET Cofund will contribute substantially to the delivery of the FACCE–JPI SRA. It will thereby also contribute to the overall EU objective of building the European Research Area through enhanced cooperation, coordination and alignment of national research programmes. The action FACCE SURPLUS also aims at implementing other joint activities such as organizing workshops, scientific events, clustering of research platforms and infrastructures in the field of food and non-food biomass production and transformation systems, and also additional joint calls without EU cofunding. Launching such joint calls on a regular basis would pave the way to the long term objective of FACCE SURPLUS to establish a self-sustaining joint programme for FACCE-JPI. This will include establishing links with ongoing FACCE-JPI actions as well as related EU and international initiatives. FACCE SURPLUS will also support innovation and value creation from biomass in a sustainable way. The ERA-NET Cofund instrument is appropriate for FACCE-JPI, since it provides additional incentive to participating countries to engage financially on the field of sustainable and resilient agriculture, but also includes the flexibility to implement further activities to contribute to the establishment of a renewable bioeconomy in the ERA.

Keywords: environmentally sustainable growth and intensification of agriculture,biomass,food,non food,feed,fibre,biorefinery
Understanding the Mediterranean Salinity Crisis (SALTGIANT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Spain,Italy,Italy,Israel,Germany,Spain,Iceland,Spain,Italy,Sweden,Norway,Bosnia and Herzegovina,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-02-01
End date: 2022-07-31
Duration (months): 54.0
Total project cost (EUR): 3893087.88
EU funding (EUR): 3893087.88
Participants: 39
Project status: CLOSED

As society moves into an era where environmental change has an ever-growing place in the political agenda, the demand for a new generation of scientists working at the interface between the natural and social sciences is growing. SALTGIANT contributes to satisfy this demand within a rare cross-disciplinary network of natural and social scientists dedicated to understanding the formation of the Mediterranean Salt Giant, one of the largest salt deposits on Earth, and its implications for sub-seafloor microbial life, risk assessment in the oil industry, geo-economics of the Mediterranean region and the history of oceanography. SALTGIANT will bring together 22 academic organizations (11 beneficiaries, 11 partners), 2 private sector Oil&Gas companies and 1 specialist in transferable skills training from 8 European countries to stimulate interdisciplinary and intersectorial knowledge exchange between geologists, geophysicists, geochemists, microbiologist, geographers and historians in a network with PhD students at its core. SALTGIANT combines (i) geological and geochemical field work, (ii) laboratory measurements and experiments, (iii) numerical modeling at a wide range of spatial and temporal scales and (iv) empirical social sciences data collection and analysis, guaranteeing exposure of the research fellows to state-of-the-art scientific knowledge and hands-on practical training in a field rich in applications of both intellectual and societal relevance. Through its innovative blend of training and research activities, SALTGIANT will boost the employability of its research fellows in academia and in the private sector, particularly the energy sector, including Oil & Gas and geothermal, resource management, geological storage and numerical modeling, as well as in governmental agencies (Ministries of the Environment, Sustainable Development and Energy), international organizations (European Environment Agency, EEA; United Nations Environmental Program, UNEP) and NGOs.

Keywords: salt,petroleum,tectonics,drilling hazards,deep life,geoeconomics,science history,modeling
Airspace User Support to Arrival Management (Airline Team xStream)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Ireland,Germany,Switzerland,France,France,France,United Kingdom,United Kingdom
Call: Arrival Management Extended to En-route airspace (H2020-SESAR-2016-2, 2016)
Start date: 2018-02-01
End date: 2020-01-31
Duration (months): 24.0
Total project cost (EUR): 2572803.75
EU funding (EUR): 1800962.6400000001
Participants: 8
Project status: CLOSED

The SESAR work programme is in the Airline TEAM 2020 consortiums’ understanding an integrated Programme, involving all relevant stakeholders, where SESAR Solutions are matured for integration into the European ATM network in order to enhance its operational and economic efficiency, safety, security and capacity. It further develops and delivers the necessary operational and technical materials (specifications, procedures, prototypes, validation reports, etc.) for the progressive industrialisation, deployment and operation of a new ATM system. The consortium expects that SESAR 2020 will bring new ideas to the market and increase the pace of change in ATM, being part of the technology pillar of the European Union’s Single European Sky (SES). Ultimately, this means greater mobility and choice for our passengers in Europe; a more collaborative and better performing network. SESAR 2020 is also addressing the technology improvements as virtualisation and ATC contingency readiness, needed for better air traffic management in case of strikes and disruptions Aviation is a global industry and interoperability together with global harmonisation are key for its safe and sustained growth. The consortium will operationally support by this offer a project which will demonstrate the benefits for Airspace User (AU) in the operation of cross-border Arrival Management systems (AMAN) with an extended horizon in accordance with the Pilot Common Project (PCP) First Air Traffic Management (ATM) Functionality (AF#1), as well as the demonstration of AU involvement in the operation of two AMAN-related advanced concepts: the Target Time (TT) management concept and the Arrival Flexibility (A-FLEX) concept, which connect the Extended AMAN concept to the PCP Fourth ATM Functionality (AF#4). The consortium will ensure the required operational capabilities of European airspace users to contribute to the overall project objectives of SESAR 2020 PJ 25.

Keywords: arrival management en route airspae
ProVee CE Mark and EU commercialisation plan (ProVee)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 3750635.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

ProVerum Limited, an innovative Dublin based SME focused on the development of novel minimally invasive technologies to treat Benign Prostatic Hyperplasia, a common condition in older men causing difficulty with urination with a profound deterioration in quality of life. The company’s first product (called ‘ProVee’) is a self-expanding implant that alleviates the symptoms caused by BPH. Benign Prostatic Hyperplasia is an enlargement of the prostate gland which causes impingement upon the urethra, the tube which eliminates urine from the bladder. Sufferers present with Lower Urinary Tract Symptoms (LUTS), including difficulty in urinating and urinary retention causing a frequent urge to urinate day and night and having a profound effect on quality of life. BPH is extremely common in men and is the number 1 reason men visit their urologist both in the US and Europe, with 19M men treated for BPH each year in Europe and 12M men treated for BPH each year in the US. ProVee offers the patient relief from BPH symptoms through a simple, minimally invasive, 5-minute, outpatient procedure to implant the ProVee device under local anaesthetic. Once implanted, the ProVee addresses urinary problems, is well tolerated and early data suggests has an excellent safety profile Following this H2020 EIC Accelerator project, the technology will be at TRL 8, with clinical evidence from a 50 Patient CE Trial, CE Mark approval and further commercialisation will enable the treatment of 70,000 patients in Year 4 post project.

Keywords: benign prostatic hyperplasia bph,lower urinary tract symptoms luts,enlarged prostate
Dexterous Transradial Osseointegrated Prosthesis with neural control and sensory feedback (DeTOP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Italy,Italy,Italy,Sweden,Sweden,Switzerland,United Kingdom
Call: Robotics (H2020-ICT-2015, 2015)
Start date: 2016-03-01
End date: 2021-08-31
Duration (months): 66.0
Total project cost (EUR): 5165158.75
EU funding (EUR): 4260521.25
Participants: 10
Project status: CLOSED

This project addresses the scientific, technological and clinical problem of recovery of hand function after amputation. Despite decades of research and development on artificial limbs and neural interfaces, amputees continue to use technology for powered prostheses developed over 40 years ago, namely myoelectric prostheses controlled via superficial electrodes. These devices do not purposely provide sensory feedback and are known for their poor functionality, controllability and sensory feedback, mainly due to the use of surface electrodes. The consortium has pioneered the use of osseointegration as a long-term stable solution for the direct skeletal attachment of limb prostheses. This technology aside from providing an efficient mechanical coupling, which on its own has shown to improve prosthesis functionality and the patient’s quality of life, can also be used as a bidirectional communication interface between implanted electrodes and the prosthetic arm. This is today the most advanced and unique technique for bidirectional neuromuscular interfacing, suited for the upper limb amputees, which was proven functional in the long term. The goal of the DeTOP project is to push the boundaries of this technology –made in Europe– to the next TRL and to make it clinically available to the largest population of upper limb amputees, namely transradial amputees. This objective will be targeted by developing a novel prosthetic hand with improved functionality, smart mechatronic devices for safe implantable technology, and by studying and assessing paradigms for natural control (action) and sensory feedback (perception) of the prosthesis through the implant. The novel technologies and findings will be assessed by three selected patients, implanted in a clinical centre. DeTOP bridges several currently disjointed scientific fields and is therefore critically dependent on the collaboration of engineers, neuroscientists and clinicians.

Keywords: upper limb prosthetics
Identifying RNA fate checkpoints by resolving the high-resolution spatiotemporal binding dynamics of CBC containing complexes (RNAfate)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

High-throughput transcriptomic analyses in human cell lines have found that >80% of the genome is transcriptionally active. A major part of this massive genomic output is derived from RNA polymerase II (RNAPII) activity; such as, mRNA, sn(o)RNA and long non-coding RNA. However, although these transcripts all contain 5’-m7G caps, which are common hallmarks of RNAPII-derived transcripts, their fates differ substantially as some are rapidly degraded while others remain stable and exercise diverse functions in the cell. What is the underlying mechanism? Transcript fate decisions are ultimately dictated by the proteins with which the nascent RNA associate. Central to this process is the cap-binding complex (CBC). Through its early association with the 5’-m7G cap, the CBC directs a plethora of nuclear RNA metabolic events by serving as a landing pad to recruit productive and/or destructive factors. Therefore, composition of the early RNA-protein particle plays an essential role in dictating RNA fate, and the CBC and its cofactors pose an interesting dichotomous system to study as a model for sorting mechanisms dictating RNA fate. In my project, I will delineate the spatiotemporal recruitment kinetics of selected RNA metabolic factors to identify when RNA fate decisions are made during transcription and how RNA/DNA elements contribute. To resolve the sequential loading of the CBC and its cofactors onto elongating transcripts, I will develop time course UV cross-linking and immunoprecipitation (CLIP) experiments, combining metabolic labelling of RNA, using the photoactivatable ribonucleoside analogue 4-sU, with a new and unprecedentedly high powered UV cross-linking technology employed at multiple short time increments. This will for the first time enable the study of in vivo RNA binding kinetics of RNA-binding proteins with a temporal resolution necessary to characterise co-transcriptional RNA fate decisions.

Keywords: rna fate,rna processing,rna decay,phax,next,clip,rna polymerase ii
Inflaming the microenvironment of glioblastoma tumors by ADAR1 inhibition: a two-hit approach for the treatment of brain cancer. (GlioTarget)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

The brain is our most precious organ. Not only does it orchestrate vital body functions but it also stores memories and experiences, ultimately defining the core of our human nature. Brain malignancies are particularly disheartening because they disrupt our ability to perform as individuals and hinder our social interactions. Glioblastomas (GBs) represent the most frequent and lethal form of primary brain tumors, with a median survival of 14.6 months and 15,000 newly diagnosed patients per year in Europe and the US. Current therapies invariably fail, likely due to the extreme genetic heterogeneity of GB and the presence of a highly immunosuppressive tumor microenvironment (TME). Here, I propose to exploit an innate immunity checkpoint to simultaneously target cancer cells and their supporting TME. Adenosine Deaminase Acting on RNA 1 (ADAR1) is a central component of the RNA sensing pathway. It edits endogenous self dsRNAs, which would otherwise be recognized as foreign and trigger an aberrant innate immune response. Sensing of foreign nucleic acids results in interferon production which leads to cell-growth arrest, inflammation and immune cell infiltration through the expression of interferon-stimulated genes (ISGs). ADAR1 has recently emerged as a promising immuno-oncology target, with evidence pointing towards ADAR1 loss representing a novel vulnerability of ISG-expressing cancer cells. Despite expressing ISGs, GB tumors have not been evaluated for sensitivity to ADAR1 inhibition to date. I will therefore combine genetic and pharmacologic approaches to inhibit ADAR1 in patient-derived cancer cell lines and pre-clinical mouse models of GB. My aims are: i) to understand the molecular outcomes of ADAR1 inhibition in GB cancer cells; ii) to functionally characterize the TME of GBs upon ADAR1 inhibition; iii) to evaluate the therapeutic potential of ADAR1 inhibition alone and in combination with standard of care therapy and TME-targeted immunotherapies.

Keywords: glioblastoma,tumor microenvironment,innate immunity,nucleic acid sensing,interferon response,adar1
Enhancing INNovation managament capacity of CATalan small and medium enterprises 2020 – 2021 (INNCAT2021)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Spain
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 367893.75
EU funding (EUR): 367893.75
Participants: 3
Project status: CLOSED

INNCAT 2021 describes the services offered in the context of Horizon 2020 innovation support activities and the enhance European Innovation Council (EIC) pilot, with the objective of enhancing Catalan SMEs’ innovation management capacity. The current proposal fully describes these services and proves ACCIÓ’s capacity to successfully deliver them. The services will be provided to two specific groups of SMEs: beneficiaries of the EIC and SMEs with significant innovation activities and a high potential for internationalisation. As the current coordinator of the Catalan node of the EEN (also for 2020-2021), ACCIÓ is specialised in promoting innovation and internationalisation among SMEs and has implemented several successful programmes over the last 20 years. The experience obtained, especially since the implementation of the first INNCAT pilot in 2014, has given to our team of experts a deeper knowledge of these services. ACCIÓ proposes that a minimum of 110 services will be closed in the period of 2020-2021 for enhancing the innovation management capacity of SMEs. It is 42% more services than INNCAT1516. The proposed staff is fully committed to deliver the proposed services and is trained in the IMPR3ove methodology and Innovation Health Check (IHC) and have broad and extensive expertise in innovation and business support and, management. Moreover, 6 of the proposed 9 staff members have intervened in the implementation of INNCAT for the delivery of KAM and IMPR3ove services during 2014-2016. Therefore, they are fully capable to deliver the services described and successfully advise SMEs. For this period, the project will build on the experience acquired since 2014 to obtain more impact on cases.

Keywords: key account management,enhancing innovation management capacities,smeinstrument,accelerator services
Patterned microfluidic sheets for studies of root exudation profiles (RhizoSheet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-04
End date: 2023-10-03
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Modern plant varieties have been bred to grow and increase production under non limiting soil conditions and have consequently lost their ability to capture resources efficiently. Designing an efficient fertiliser requires optimising bioavailability and mobility of nutrients. Unfortunately, bio-availability and mobility are often antagonistic. Traditional fertilisers, which package soluble mineral elements into granules, are easily acquired by plant roots but have been linked to excessive loss to the environment and pollution. Slow release fertilisation has been proposed to slow down the diffusion of nutrients to the soil, including the use of nanotechnology, but slowing down the diffusion of nutrients excessively affects root uptake. Biological fertilisation is inspired from known mechanisms observed in soil, but maintaining efficient colonisation of the root by beneficial microbes is challenging. New approaches must be developed to better control the associations taking place between plants and beneficial microbes, since fundamental knowledge to achieve this target is nowadays lacking. Roots exude a huge diversity of biomolecules, and their role in maintaining adequate beneficial microbes are mostly unknown and rarely studied. The aim of the RhizoSheet project is to apply cutting-edge microfluidic techniques based on hybrid paper-polymer technology for device fabrication. Optical sensors and novel functional materials will be applied as biochemical sensors to gain knowledge on the location of compounds secreted by roots and on the response of roots over time, when interacting with soil microbes. The acquired knowledge will be highly beneficial for the scientific and agricultural community and finds the interest of the EU in soil and food safety, the RhizoSheet project meets the interest of the Horizon Europe - the next research and innovation framework programme in particular the natural resources in Pillar 1.

Keywords: microfluidics,lab on a chip,sensors,root exudate,root microbe interactions,tomato,bacillus subtilis,crop production