Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Effects of sleep deprivation and adrenergic inhibition on glymphatic flow in humans (Human Glymphatics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-09-23
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Sufficient sleep is a key determinant of health, and sleep loss is associated with severe health risks. Nevertheless, the reason for why we sleep is not yet understood. Recently, a molecular function of sleep was described in rodents. The ‘glymphatic system’ (GS) is a sleep dependent macroscopic pathway of the brain that facilitates the removal of metabolites, including amyloid-beta. This project will for the first time reveal a sleep-driven human GS and show whether glymphatic flow (GF) can be linked to cognitive impairments associated with sleep loss. Secondly, I will promote GF with the adrenergic antagonist Carvedilol. This manipulation of glymphatic clearance may define new approaches for treating sleep-disorders and Alzheimer’s disease, or reduce or delay our need for sleep. I will investigate the human GS by applying state of the art, 5-10 Hz, ultra-fast MR sequences across sleep and wakefulness. Preliminary data show that these sequences enable the detection of cardiac, respiration, and slow pulsations, previously considered noise in fMRI imaging and distorted by aliasing effects. These pulsations are now believed to drive GF. The project will be a major step forward for sleep and neuroscience research, but also provide a key step in my career, demonstrating independent work and allowing me to learn advanced data-analysis skills and develop a novel imaging method, which I can apply in future studies. The chosen host institution is perfectly situated for the project, as they have established expertise and an exceptional skill-set in analyzing novel neuroimaging data including ultra-fast MRI. Secondly, my host provides unique infrastructure that allows for completion of the study, with key personnel in neuropsychology and data-analysis, as well as the world leading experts in glymphatic mechanisms. The project forms a foundation for a more general approach to integrate imaging of sleep-regulation and glymphatic mechanisms with patient or trait specific data.

Keywords: glymphatic system,ultra fast mri,sleep homeostasis,adrenaline,carvedilol
INCALO: Internal black carbon loading: validation of a novel biomarker (INCALO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-05-01
End date: 2020-10-31
Duration (months): 18.0
Total project cost (EUR): 149170.0
EU funding (EUR): 149170.0
Participants: 1
Project status: CLOSED

Ambient air pollution, including black carbon, entails a serious public health risk because of its carcinogenic potential and as climate pollutant. Inhalation of fossil fuel-derived particulate matter (PM) is associated with a wide range of non-pulmonary health effects. Based on the WHO report of 2015 the European health annual costs of air pollution have been estimated to US$ 1.6 trillion. Although recent studies strongly suggest that particle translocation in biological systems is biologically plausible, they do not prove that ambient fossil fuel-derived carbonaceous nanoparticles enter the human systemic circulation in real-life conditions. We developed a novel method to detect carbonaceous nanoparticles in the urine of healthy children. The ERC funded ENVIRONAGE project already made a strong case for promoting urinary carbon detection to practice by demonstrating its usefulness as individual long-term exposure marker. Taking advantage of white-light generation by carbonaceous nanoparticles under femtosecond pulsed laser illumination, we demonstrated the presence of these particles in urine and its relation with the external environmental air pollution (Saenen et al. Am J Respir & Crit Care Med, in press). This pioneering study is of innovative value, as it paved the way for a non-invasive assessment of long-term individual exposure to one of the most toxic air pollutants, black carbon, and will be useful in epidemiological investigations, biomonitoring studies as well as in occupational settings. The aim of the INCALO (INternal black CArbon LOading) project is to promote the output of the ENVIRONAGE project towards a process for facilitation and commercialization of internal markers of exposure to black carbon.

Keywords: biomonitoring,environmental epidemiology,exposomics,ambient air pollution
Connecting Ad-Impressions with Purchase. The new advanced Advertisement at the point of sales. (CyreenApplication)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Based on these principles, we developed our first marketing solution C.A.P. (Connecting Ad-Impressions with Purchase): A novel digital marketing channel installed in grocery stores. The intelligent system ensures that shoppers see relevant content during their purchase decisions. C.A.P. connects the seen content with a shopper’s transactional data, enabling unique big data analyses to measure the advertising effectiveness. After several years of development, C.A.P. was launched mid-2018 in Germany and since then, the system’s market demand (profitability), technical functionality and advertising effect hass been continuously monitored. 100% of the store managers want to keep the system. Various brands have run a campaign on C.A.P. and are enthusiastic about its impact and respective analytical insights – therefore our customers were willing to pay prices which are several times higher than average TV advertising. This highlights the importance to quickly build up reach.

Keywords: advertising,retailers,publicity,measurable impact on sales
Digital Environment for Cognitive Inclusion (DECI)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Innovation actions
Countries involved: Italy,Italy,Spain,Israel,Sweden,Netherlands
Call: Advancing active and healthy ageing with ICT: ICT solutions for independent living with cognitive impairment (H2020-PHC-2014-single-stage, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 3184975.71
EU funding (EUR): 2921577.0
Participants: 9
Project status: CLOSED

The average human lifespan increase has significant impacts on healthcare organizations and on every aspect of citizens’ wellbeing. One of the main areas of intervention focuses on elderly people affected by Cognitive Impairment (CI). These people, especially when living alone, are significantly exposed to undeniable risks that can affect their health (falling, malnutrition, hygiene issues, etc.). Limitations regarding CI can also translate into social and physical limitations during daily activities (cooking, showering, ect.). The DECI project aims to improve a healthy lifestyle for elderly people effected by CI, passing through a system monitoring vital signs, treating and managing diseases and, in general, supporting the adoption of a healthy and independent lifestyle. To achieve this, the project will revolve around the definition of a business model to supply assistance services (in-house for the elderly and with a remote-based approach supporting autonomy), allowing independent living for elderly people affected by CI, granting high levels of quality of life. The proposed business model will include an up-to-date organizational model, both modular, flexible and scalable, meant for regulators and service suppliers, and the support of an IT platform based on innovative and easy-to-replicate technologies. In order to validate the business model inside real-life environments, four pilot projects will be kicked-off, by involving patients in four different countries: Israel, Italy, Spain and Sweden. Every pilot project will pass through the implementation of the organizational model and the IT solution defined as part of the DECI initiative, therefore allowing tuning of the model and of all implemented devices. Business plan and economic models (in private/ public sectors and in different countries) will be adopted in order to address cost coverage issues related to the implementation of new procedures and technological solutions inside real healthcare environments.

Keywords: ict solution,cognitive impairment,digital environment,social inclusion,socio care,healthcare,organization model,elderly people
Rationalising Full Compensation of Non-Pecuniary Damages to Reconcile Equal Treatment and Personalisation (FullCompensation)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-01
End date: 2023-09-30
Duration (months): 18.0
Total project cost (EUR): 131679.36
EU funding (EUR): 131679.36
Participants: 1
Project status: SIGNED

In the EU, full compensation of non-pecuniary damages remains fragmented and subjective, leading to unequal outcomes within jurisdictions. This is despite numerous attempts to reduce variability, e.g. barèmes and tables. The project aims to develop evidence-based guidelines for decision-makers to award damages, reconciling equal treatment and personalisation. Such guidelines will be developed into a model legislative proposal for Member States to foster rationalisation in this sector. The goal is to reduce bias, uncertainty, subjectivity and unequal treatment in the assessment of non-pecuniary damages, minimising the social and individual costs of awarding such damages, while at the same time investigating the actual perception of full compensation by victims. To this end, the project will (1) explore damages awarding mechanisms in the EU and the legal aids to assess compensation; (2) investigate, through online and laboratory behavioural experiments, the actual perception of fair and full compensation by adjudicators, identifying their mechanisms of psychic satisfaction and their cognitive reaction to different legal aids; (3) based on the collected experimental results, develop tools to assess compensation and assist decision-making processes.

Keywords: civil liability,tort law,full compensation,non pecuniary damages,pain and suffering,harmonisation,empirical legal studies,behavioural and economic analysis of law
Medical Genomics and Epigenomics Network (MEDGENET)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Sweden,Greece,Czechia
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 1016531.25
EU funding (EUR): 974529.25
Participants: 4
Project status: CLOSED

The main goal of MEDGENET consortium is to use synergies and existing expertise in EU leading institutions such as EMBL, Uppsala University and CERTH to reinforce the productivity and competitiveness of the CEITEC in the field of medical genomics and epigenomics. We propose clear strategy based on combination of unique complementary skills present in partner institutions that will transform CEITEC into a key leader in the field. ERA Chair who recently joint CEITEC already initiated the transformational change of the institute and TWINNING framework will further support sharing her international contacts with other CEITEC researchers. MEDGENET aims to create well-educated taskforce of biomedical researchers, who will notably contribute to the development of new genomics and bioinformatics tools and their application in clinical practice. Proposed project will enable to establish the best practices for performing innovative and high-quality biomedical research and to strengthen CEITEC´s competence to translate the research results into high value-added clinical applications. Stimulation of knowledge exchange, implementation of cutting edge technologies and mastery of modern genomics and bioinformatics methodologies will have a direct impact on the overall research and innovation potential of CEITEC and will increase its visibility in the international scientific community.

Keywords: medical genomics,rna processing,microrna,prognostic biomarkers,targeted therapy,bioinformatics,genome instability,immune cell profiling
Breakthroughs in Quantitative Magnetic resonance ImagiNg for improved DEtection of brain Diseases (B-Q MINDED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Sweden,Belgium,Belgium,Belgium,Sweden,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-01-01
End date: 2022-03-31
Duration (months): 51.0
Total project cost (EUR): 3861067.32
EU funding (EUR): 3861067.3200000003
Participants: 14
Project status: CLOSED

Magnetic resonance imaging (MRI) is one of the most useful and rapidly growing neuroimaging tools. Unfortunately, signal intensities in conventional MRI images are expressed in relative units that depend on scanner hardware and acquisition protocols. While this does not hinder visual inspection of anatomy, it hampers quantitative comparison of tissue properties within a scan, between successive scans, and between subjects. In contrast, advanced quantitative MRI (Q-MRI) methods like MR relaxometry or diffusion MRI do enable absolute quantification of biophysical tissue characteristics. Evidence is growing that Q-MRI techniques detect subtle microscopic damage, enabling more accurate and early diagnosis of neurodegenerative diseases. However, due to the long scan time required for Q-MRI, causing discomfort for patients and limiting the throughput, Q-MRI methods have not entered clinical practice yet. B-Q MINDED aims to overcome the current barriers by developing widely-applicable post-processing breakthroughs for accelerating Q-MRI. The originality of B-Q MINDED lies in its ambition to replace the conventional rigid multi-step processing pipeline with an integrated single-step parameter estimation framework. This approach will unlock a wealth of options for optimization of Q-MRI. To accomplish this goal, B-Q MINDED proposes a collaborative cross-disciplinary approach (from basic MR physics to clinical applications) with strong involvement of industry (2 MRI vendors and 3 MRI-software SMEs). B-Q MINDED proposes a unique training platform that enables young European researchers to develop a holistic view on Q-MRI research and development. The fellows enrolled in B-Q MINDED will have access to a variety of network-wide training events and will gain essential transferable skills that will positively affect their employability in academia and industry. By combining research, innovation, and education, B-Q MINDED will pave the way for introducing Q-MRI into the clinic.

Keywords: quantiative mri,diffusion mri,mr relaxometry
Innovative biotechnology using mycorrhizal fungi to restore and remediate damaged soils (MYRES)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2019-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

MYRES provides the soil remediation industry with a biotechnology that has been largely tested in laboratory. Our company INOQ is ready to apply its expertise on mycorrhizal fungi to provide an innovative bioremediation technology to treat contaminated and degraded soils in Europe (and worldwide in subsequent phases). Mycorrhiza is the symbiotic association between fungi and roots of vascular plants. It increases the plant’s ability to resist diseases and is able to detoxify pollutants. We will identify and select the most accurate mycorrhizal fungi species to restore soil properties, as well as treat organic and inorganic contaminants. MYRES offers a complement and/or alternative to current remediation Ex situ and In situ techniques. Its characteristics includes: 100% natural, non-GMO, compatible with other techniques (accelerates phytoremediation), applicable for both residential and agricultural purposes, cost-effective method. To date there are no commercial applications of mycorrhizal fungi on soil remediation in Europe. Therefore, we identify our competitive advantage given our technical and commercial experience with similar applications. Our know-how and infrastructure include a culture collection and stock of more than 50 strains, hosting plant species, laboratories, nursing areas and green houses. Our technology is ranged between TRL 6 and TRL 7. Our aim is to be leader provider of Mycorrhiza based bioremediation technology. Our target leads are segmented in 3 groups: Soil remediation firms; Contractor firms managing remediation or land reclamation projects; and Firms with remediation activities as part of their operations (i.e. construction and Mining). European Union’s estimations include 490,000 contaminated sites with an average remediation cost of €180.000/site. Our estimated annual turnover will increase from €770.000 within the first three years to 2,3 Million within the next 8 years after phase 2 with continuous growth rate of at least 25%.

Keywords: bioremediation,sustainable soil remediation,land reclamation,mycoremediation
Digital Forensics in the Historical Humanities: Hanif Kureishi, The Mass Observation Archive, Glyn Moody (DFitHH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2019-08-31
Duration (months): 12.0
Total project cost (EUR): 91727.4
EU funding (EUR): 91727.4
Participants: 1
Project status: CLOSED

The use of personal computers has fundamentally changed the historical record. “Born digital” documents – private digital archives, legal and public digital repositories, websites and social media content, digital art – have entered the historical record and become part of our shared cultural heritage. Yet few scholars in the historical humanities can preserve, process and analyse these primary sources with the digital forensic methodologies required to maintain evidential integrity, fixity, and authenticity, to recover data, and to draw historically valid conclusions from the digital materiality of the evidence and its preserved technological context. There is a clear need for this situation to change. My project will make that happen. To effect change I will draw on my expertise in born-digital philology and digital forensics to undertake exemplary analysis of born-digital corpora in three distinct UK-based archives that have not been subjected to digital forensic analysis: the archive of the celebrated author Hanif Kureishi at the British Library (BL), the internationally renowned Mass Observation Project Archive (MOPA) based at the University of Sussex (UoS), and the private digital archive of the technology writer and journalist Glyn Moody. Working across these three archives will demonstrate the innovative potential of digital forensic methodologies in the historical humanities and set forensic standards for future research using born-digital archives. This fellowship is, therefore, timely. It will effect real and long lasting change in the historical humanities. It will evolve the state of the art in archive science, philology and historical scholarship. It will create a significant change in engagement with the digital historical record in the historical humanities, ensuring that humanities continue to be able to answer the important political, social, and cultural questions of our times.

Keywords: digital forensics,archival science,born digital archiving,digital humanities,literary criticism,history,material history,analytical bibliography,philology
An online digital logbook to protect and prove authorship, and to share scientific results (ResearchProof)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Italy
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2017-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The scientific publishing sector is facing significant challenges related to authorship and dissemination of research outputs. Currently, authorship acknowledgement is provided only upon final publication of a paper, which can be a lengthy process. As a result, sharing of unpublished results is rare, leaving the potential of the early dissemination of scientific work unexploited and ultimately slowing down the pace of research worldwide. Innovaetica has developed ResearchProof, an open access (OA) online platform for depositing, pre-publishing and sharing scientific work from any discipline and at any stage of the research cycle. Its core feature is a digital logbook where researchers can store any kind of (intermediate) research artefacts, obtaining a legally valid proof of authorship thanks to timestamping technology. The innovative use of blockchain cryptography makes for a particularly safe environment that relies on a distributed, decentralized database architecture. ResearchProof overcomes the limitations of conventional publishing by offering speedy publication without editorial bias or lengthy pre-publication peer review as well as instant intellectual property protection for scientific data even for intermediate research outputs. Thanks to the pre-publication and sharing functionality, scientists can make such findings immediately available to the scientific community, receiving proper credit and boosting their chances of gaining access to new collaborations, publications and grants. The ResearchProof project contributes to enabling broader access to scientific publications and data, in line with the ideas of a global knowledge society and of the European Research Area. The phase 1 feasibility study will focus on validating the business model and commercialization strategy, planning of all activities for further product development and pilot test with end-users, and elaborating the business scale up and marketing plan.

Keywords: open access,scientific publishing,research,authorship protection,timestamping,blockchain,publication,scientific paper