Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Tree-based Ridge Extractor for image analysis (T-REx)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Accurate and reliable analyses of medical images have become a key step to determine the presence or severity of diseases, directly impacting the clinical care for patients. Among the numerous and various biomedical image analysis, the identification of blood vessels and the associated vascular trees is one of the most central topics for diagnosis of the coronary, lungs, liver, or retina, which require detection methods to assist physicians. Many such methods show intrinsic limitations due to the required pre-processing of the images, to the approach used, e.g. limited training databases, etc. Complex filamentary patterns, such as the vascular trees, are common and widely observed in geology, astrophysics, etc. In astrophysics, elongated structures made of the alignment of galaxies, called filaments of the cosmic web (CW), reveal the nature of matter in the Universe and the way it assembles over the ~14 billion years’ history of the cosmos. For these reasons, detecting CW filaments and studying them is an increasingly important topic in astrophysics and is one of the aims of the ERC-Advanced project ByoPiC (Baryon Picture of the Cosmos). This proposal is a direct offspring of ByoPiC. It is the first step of a multi-step technology transfer strategy which aims at transferring an innovative algorithm to detect filaments in the distribution of galaxies to the analysis of biomedical images, laying the ground for applications in scores of other domains, e.g., satellite imagery, geophysical tomographic data, engineering, etc.
SHAPE. Deciphering sarcoplasmic reticulum shaping in heart function (SHAPE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

Cardiovascular diseases (CDs) are the main cause of death in the European Union (EU) and they cost the EU €210 billion a year. Expanding the molecular knowledge on CDs is a key factor in the struggle against them. The sarcoplasmic reticulum (SR) is one of the chief organelles involved in proper cardiomyocyte function due to its implication in calcium handling, and because of that, one of the principal therapeutic targets. SR comprises at least two different regions whose function is well known, however the molecular actors that profile it and how the correct arrangement of them is obtained remain unknown. In contrast, endoplasmic reticulum (ER) shaping and how changes in its shape affects ER function have been recently described. Due to this shape/function relationship and considering the similarities between ER and SR, it is likely that SR shape modulators are fundamental also in maintaining proper SR function. In this scenario, it is tempting to speculate that ER shape alteration is involved in the development of CDs. The aim of this project is to study how the SR shape affects its function. This ambitious goal will be achieved by bringing together my expertise in cardiac physiology with the know-how of my supervisor in ER shape/function and my co-supervisor knowledge on calcium signalling, by using the powerful genetic model Drosophila melanogaster. The results of the project will impact the cardiac function knowledge and could provide possible new therapeutic targets against CDs. Moreover, the results of the project could impact other fields of research, as well as muscular research, by expanding the understanding of SR shape/function relationship.

Keywords: heart,calcium,drosophila melanogaster,sarcoplasmic reticulum,endoplasmic reticulum
It takes two to tango: a synergistic approach to human-machine decision making (TANGO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Italy,Germany,Belgium,Spain,Serbia,United Kingdom,France,Ireland,Sweden
Call: AI for human empowerment (AI, Data and Robotics Partnership) (RIA) (HORIZON-CL4-2022-HUMAN-02, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 7008798.75
EU funding (EUR): 7008798.75
Participants: 25
Project status: SIGNED

Artificial Intelligence (AI) holds enormous potential for enhancing human decisions, improving cognitive overload and lowering bias in high-stakes scenarios. Adoption of AI-based support systems in such applications is however minimal, chiefly due to the difficulty of assessing their assumptions, limitations and intentions. In order to realise the promise of AI for individuals, society and economy, people should feel they can trust AIs in terms of reliability, capacity to understand the human’s needs, and guarantees that they are genuinely aiming at helping them. TANGO will develop the theoretical basis and computational framework for hybrid decision support systems (HDSS) in which humans and machines are aligned in terms of values and goals, know their respective strengths, and work together to reach an optimal decision. To this end, TANGO will develop: 1) A cognitive theory of mutual understanding and hybrid decision making, of intuitive vs deliberative approaches to decision making and of how they affect our trust in human and AI teammates. 2) Cognition-aware explainable AIs implementing synergistic human-machine interaction, enabling machines to determine what information a specific decision maker (e.g., layperson vs expert) needs, or does not need, to reach an informed decision. 3) A “Human-in-the-loop” co-evolution of human decision making and machine learning models building on bi-directional, explanation-augmented interlocution. The TANGO framework will be evaluated on four high impact use cases, namely supporting: i) women during pregnancy and postpartum, ii) surgical teams in intraoperative decision making, iii) loan officers and applicants in credit lending decision processes, and iv) public policy makers in designing incentives and allocating funds. Success in these case studies will establish TANGO as the framework of reference for developing a new generation of synergistic AI systems, and will strengthen the leadership of Europe in human-centric AI.

Keywords: trustworthy hybrid decision support,synergistic human machine learning,cognition aware ai
Earth laughs in flowers: Research training in horticultural precision breeding addressing flower colour as established model (COLORnamental)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-04-01
End date: 2026-05-31
Duration (months): 38.0
Total project cost (EUR): 249301.2
EU funding (EUR): 249301.2
Participants: 3
Project status: SIGNED

The COLORnamental team comprises a promising Experienced Researcher (ER) in the field of horticulture and molecular breeding and her future supervising team, i.e. an academic beneficiary in Austria, an associated partner from the commercial horticultural industry in Germany and an academic associated partner in Germany hosting a 6 month secondment. Together they have defined an innovative and challenging research project that offers a well-balanced mixture of research at the interface of fundamental and applied research addressing promising opportunities in the non-academic sector and scientific hot-spots in plant research simultaneously. An innovative breeding approach will exploit flower colour as an established model to implement for the first time the use of MAD7 nucleases in ornamental breeding, and protoplast transformation to modify the bract colour of poinsettia. The genome editing approach addresses the substrate specificity of dihydrolflavonol 4-reductase (DFR) and will promote the accumulation of orange pelargonidin based pigments. Flavonoids, including the colourful anthocyanins, are the most important secondary metabolites, contributing a broad range of physiological functions in plants and humans, the latter when consumed as plant derived food. This makes them an attractive topic for industry and academia across many research fields. The pathway has always served as an important model to establish fundamental scientific knowledge of enzymes, gene regulation in plants and a variety of evolutionary processes. This will allow the ER to augment her expertise with knowledge that is seen as the future of food security, while herself imparting a new perspective to her hosts. A tailor-made training plan, composed of scientific key transferable skills elements for public and private sector employment (research management, presentation and language skills) was designed to empower the ER to move up the career ladder.

Keywords: ornamental plants,flower colour,breeding genome editing,protoplasts,anthocyanin,poinsettia,bracts,crispr,endonuclease,dihydroflavonol 4 reductase,flavonoid 3 hydroxylase,pelargonidin
The Cultural Vanguard of Workers’ Movements: A Social History of East Central European Avant-Garde between the Two Wars (ProletGard)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Hungary
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1465135.0
EU funding (EUR): 1465135.0
Participants: 1
Project status: SIGNED

This project investigates the interaction between workers’ movements and the transnational scene of modern art. The avant-garde forever transformed the relationship between art and everyday life. This project argues that this shift not only dynamized the art world but also extended well beyond the confines of the cultural sphere, transforming the working-class communities in the successor states of the Austro–Hungarian Empire as well, where avant-garde art played a pivotal role in creating a workers’ movement counterculture. The project postulates that the transnational avant-garde scene, and especially the related network of periodicals, enabled reciprocal interactions. The amalgamation of pre-existing working-class practices in the region with avant-garde techniques also had an impact on global modernisms. To explore these interactions, the project assembles an interdisciplinary team of seven researchers to analyze how working-class and avant-garde publications were circulated, received, and produced in this region between the two wars. The project comprises three thematic components, examining: 1) how related periodicals transcended administrative and linguistic boundaries of newly established nation-states; 2) novel reading and performative practices; 3) the extent to which these publications served as arenas of conflict and negotiation among various cultural trends within the heterogeneous milieu of workers’ movements. By examining avant-garde journal production and their everyday use in East Central Europe, the project not only seeks to readjust the Western-centric viewpoint on modern art networks but also establishes the basis for a comprehensive exploration of the cultural history of working-class groups in the region and beyond. By rewriting the history of interwar avant-garde press from below, the project analyzes East Central European modernisms on two scales, as inextricably linked both to local workers’ movements and the transnational avant-garde press.

Keywords: workers movements,east central europe,avant garde,cultural transfers
Breakthrough Neoantigen-specific Tumor-Infiltrating Lymphocyte Therapies Through Novel Dendritic Cell Reprogramming (Repro-TIL)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden,Denmark
Call: Transition Open 2024 (HORIZON-EIC-2024-TRANSITION-01, 2024)
Start date: 2025-06-01
End date: 2028-05-31
Duration (months): 36.0
Total project cost (EUR): 3276149.46
EU funding (EUR): 2480367.37
Participants: 3
Project status: SIGNED

Solid tumors present a significant challenge in oncology due to the limited efficacy of current therapies and resistance to immunotherapies like checkpoint inhibitors. While adoptive cell transfer (ACT) using Tumor-Infiltrating Lymphocytes (TIL) has shown promise in immunogenic tumors like melanoma, broader success has been hindered by inefficient TIL expansion, T-cell exhaustion, and low tumor reactivity (<0.5% tumor-reactive clones in TIL products). These limitations result in inconsistent outcomes and slow clinical adoption. The Repro-TIL project aims to address these challenges by establishing a first-in-class platform designed to selectively expand neoantigen-specific, tumor-reactive TILs. The project builds on the ERC POC project 'NeoIDC,' which introduced a novel method for reprogramming cancer cells into antigen-presenting conventional type 1 dendritic cells (cDC1s), leading to tumor-reactive T cell priming. Repro-TIL approach enhances the production of highly tumor-specific TILs, offering a more effective immunotherapy for solid tumor patients. Repro-TIL will focus on completing preclinical validation and CTA-enabling studies to reach TRL6. The project will optimize the platform for TIL expansion, identify biomarkers of TIL potency, develop a GMP-compliant manufacturing process, and establish regulatory and commercial pathways for future clinical trials and market entry. The project’s multidisciplinary consortium brings together expertise in translational immunotherapy, ACT manufacturing, regulatory strategy, and business development. This combination ensures successful project implementation and lays the groundwork for commercialization. By its conclusion, Repro-TIL will be positioned as a superior ACT solution, with the potential to significantly improve treatment outcomes in melanoma and hard-to-treat solid tumors such as sarcoma and breast cancer. This scalable, cost-effective platform could set the stage for a new era of personalized cancer therapies.

Keywords: tumor infiltrating lymphocytes,dendritic cell reprograming,adoptive cell transfer,neoantigen,cancer immunotherapy,biomarker discovery,clinical scale manufacturing
Leveraging the impact of gut microbes to advance the efficacy of CAR-T cell immunotherapy. (PowerMiT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1999819.0
EU funding (EUR): 1999819.0
Participants: 1
Project status: SIGNED

T cell therapy with chimeric antigen receptor (CAR)-T cells is a curative-intent, transformative treatment aimed to boost antitumor abilities of host T cells against refractory/relapsed B cell malignancies and, recently, against refractory/relapsed myeloma. Major challenges of current CAR-T cell immunotherapies are the loss of long-term efficacy, the occurrence of toxicities including infections, and a lack of personalized patient strategies including biomarkers for response prediction and interventions to enhance CAR-T cell efficacy. This proposal builds on our first evidence for a major role of the gut microbiome in CAR-T cell therapy, and addresses these challenges by presenting a translational research strategy aimed to dissect and leverage the impact of gut microbes in its antitumor efficacy. In Aim 1, we will investigate the hypothesis that gut and intratumoral microbiome configurations and its metabolites are associated with clinical response of CD19-CAR-T cells in lymphoma, with immunophenotypes of these engineered T cells and the tumor immune microenvironment. We will examine the effects of nutrition and antimicrobial drugs on microbiome features to identify potential mechanisms and therapeutic levers. In Aim 2, we will address the biology of microbiome-CAR-T cell interactions through experimental gut microbiome modulations, and humanizing mice with patient-derived microbial ecologies and individual species and strains in preclinical research models. In Aim 3, we will assess potential therapeutic interventions to increase CAR-T efficacy by investigating the action of microbiome-derived metabolites on CAR-T cells and studying phage- and diet-based interventions to mitigate antibiotic-induced gut microbiome dysbiosis. Characterising the function of the microbiome and its products in CAR-T immunotherapy harbours an enormous potential to improve current and future T cell transfer therapies for numerous patients suffering from cancer.

Keywords: car t cell therapy hematologic malignancy metabolome gnotobiotics
NATURESCAPES: NATURE-BASED SOLUTIONS FOR CLIMATE RESILIENT, NATURE POSITIVE AND SOCIALLY JUST COMMUNITIES IN DIVERSE LANDSCAPES (NATURESCAPES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Resilient, inclusive, healthy and green rural, coastal and urban communities
Action type: Research and Innovation actions
Countries involved: Netherlands,Austria,Germany,Sweden,Portugal,Ireland,Colombia,Switzerland,United States
Call: Assessing the socio-politics of nature-based solutions for more inclusive and resilient communities (HORIZON-CL6-2022-COMMUNITIES-01, 2022)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 7104946.75
EU funding (EUR): 7087446.0
Participants: 11
Project status: SIGNED

NATURESCAPES addresses the pressing challenge of realising the transformative potential of nature-based solutions (NBS) for climate change, biodiversity loss and social justice. Despite progress in the field, our knowledge of the synergies and trade-offs from implementing NBS at scale across diverse and interconnected landscapes is limited. At the same time, there remain challenges in designing the governance arrangements, finance and forms of citizen engagement are needed while the value NBS for diverse social actors is increasingly contested - especially where they seem to bring benefits to some and new forms of inequity and exclusion to others. Advancing the transformative potential of NBS requires that we address these underlying challenges together – ensuring they are both effective and just. NATURESCAPES will advance our understanding of how NBS across interconnected urban, rural and coastal landscapes generate benefits for diverse communities, particularly in areas of socio-economic disadvantage, inequity and risk. We will analyse the synergies/trade-offs emerging for climate, biodiversity and communities in 30 ‘naturescapes’ across Europe, Latin America and the Caribbean (LAC) and the USA, including 12 in-depth case-studies focusing on the dynamics of implementation, creating new insights and tools. In 7 of these cases we will co-design interventions with local collaborators that test transformative theories and practices of change and identify how these can be replicated. Led by Utrecht University, the NATURESCAPES consortium brings together expertise across the sciences, social sciences and humanities from five European Universities, The Nature Conservancy, WWF and Grupo Laera (a leading consultancy in NBS and ecosystem services in LAC), and an international collaboratory of stakeholders. Together, we will adopt a transdisciplinary approach to take forward the realisation of NBS that are transformative for climate change, biodiversity and communities.

Keywords: transformative change social justice climate change biodiversity conservation landscape transdisciplinarity
Dissecting the code for regulatory T cell entry into the tissues and differentiation into tissue-resident cells (TregCode)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: United Kingdom
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-04-01
End date: 2031-03-31
Duration (months): 60.0
Total project cost (EUR): 2499960.0
EU funding (EUR): 2499960.0
Participants: 1
Project status: SIGNED

Foxp3+ regulatory T cells (Tregs) are highly potent immunosuppressive cells. Most of our understanding of Tregs is based on the population present in lymphoid tissues, however to harness their anti-inflammatory power in the clinic we need to understand the tissue-resident population. Converting generic Tregs into expanded proto-tissue Tregs, capable of entering inflamed tissues, adapting to local conditions, and driving an anti-inflammatory pro-rejuvenation process would transform cell therapy. However to be able to encode a tissue-resident function into Tregs, we first need to decode the cellular induction signals that allow a Treg to become a tissue Treg, and decode the molecular processes of Treg tissue entry and reprogramming into the residential phenotype. This project seeks to dissect Treg tissue-residency at an unprecedented scale. The applicant’s team has developed and validated cutting-edge technology, “FlowCodes”, to enable massively-parallel functional testing of the tissue Treg repertoire and genetic control. The project will test the cellular behaviour of ~500 tissue Treg TCRs and ~500 gut Treg TCRs through retrogenic TCR analysis, across multiple organs, in health and disease, identifying the site of Treg induction and disease-responsiveness for each. The project will further test ~400 potential genetic cofactors (migration genes, transcription factors, metabolic adaptors), for contribution to tissue residency and potential to aid anti-inflammatory responses. Finally, the project will provide a proof-of-concept for re-encoding the identified residency features, and systematically test combinations of decoded TCR and genetic factors for the ability to augment tissue-residency and disease suppression in Tregs. The project therefore not only unravels the biological rules for Treg residency, it provides a pathway back to Treg cell therapy engineering.

Keywords: regulatory t cells treg,t cell receptor tcr,t cell differentiation,tissue entry