Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative Business Models for Market Uptake of Renewable Electricity unlocking the potential for flexibility in the Industrial Electricity Use (IndustRE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Spain,Germany,Italy,Italy,Belgium,United Kingdom,United Kingdom
Call: Market uptake of existing and emerging renewable electricity, heating and cooling technologies (H2020-LCE-2014-3, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 1897227.5
EU funding (EUR): 1897227.5
Participants: 9
Project status: CLOSED

The flexibility of the industrial electricity demand has been identified as a potential that through innovative business models can facilitate further growth of variable renewable energy, while reducing the industrial electricity costs and contributing to the European energy policy goals. In this project the large industry is working with the renewable energy community to identify and implement business models for supplying variable renewable electricity to industrial users with flexibility in their demand, creating win-win situations. Several variations of the business models will be described covering different options like on and off-site renewable energy production. The business models will be adapted to 5 industrial sectors (Chemicals, non-ferrous metals, cold storage, steel, and water treatment) and 6 target countries (Belgium, France, Germany, Italy, Spain and UK). Tools will be developed to facilitate adoption of the business models: Model contracts adapted to the target countries and the different business models and a methodology that assesses the flexibility in industrial units and its value within the business models. The methodology will be transferred to third parties and will be applied in 6 case studies covering all target sectors and countries. Recommendations for improvements in the regulatory and market framework will be formulated and promoted. A top-down and a bottom-up methodology will be used to quantify the potential for further cost-effective grid integration of variable renewable electricity by the exploitation of the industrial electricity demand flexibility. The use of a sophisticated power system model and detailed analysis will provide reliable data on the impact the policy recommendations could have. An ambitious campaign will be carried out for engaging the target groups in direct action implementing the business models and informing the interested actors about the project activities and results.

Keywords: industrial electricity demand,flexibility,variable renewable energy,grid integration,cost of industrial electricity
Molecular-genetic mechanisms of extreme adaptation in a polyphagous agricultural pest (POLYADAPT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-06-01
End date: 2023-11-30
Duration (months): 66.0
Total project cost (EUR): 1926250.0
EU funding (EUR): 1926250.0
Participants: 1
Project status: SIGNED

Generalist (polyphagous) herbivores can feed and reproduce on many different plant species and include some of the most pesticide resistant and notorious pests in agriculture. An evolutionary link between host plant range and the development of pesticide resistance has been suggested. Although crucial for devising efficient crop protection strategies, the mechanisms underlying rapid adaptation are not well understood, especially in generalists. The spider mite Tetranychus urticae is a global pest known to feed on 1,100 different hosts from 140 plant families, including most major crops. With experimental advances and new tools developed for T. urticae, we are now poised for fundamental advances in understanding the molecular genetic make-up of adaption in generalist pests. We will generate a large collection of fully inbred and resistant mite strains and describe the sampled genomic variation in the context of selection and adaptation. We will study gene regulation mechanisms and quantify cis versus trans regulation of gene expression on a genome wide scale. We will then create a unique population resource that will allow us to map master regulators of gene expression and construct a gene-regulatory network of adaptation responsive genes. In a highly replicated experimental evolution study, combined with Bulk Segregant Analysis (BSA), we will uncover, without a prior hypothesis, the genomic loci that underlie complex cases of resistance and plant adaptation. A core set of adaptation genes will be validated by functional expression and high-throughput interaction assays. Further validation will come from the development of genome editing tools. In summary, POLYADAPT will exploit the genomic tools now available for spider mites to elucidate regulatory and causal variants underlying the extreme adaptation potential of polyphagous pests. This will in the long term lead to innovative methods of pest management.

Keywords: insecticide resistance,detoxification,xenobiotic metabolism,tetranychus urticae,mode of action,adaptation,molecular acarology,target site resistance,over expression
High Cycle Fatigue Prediction Methodology for Fibre Reinforced Laminates for Aircraft Structures in CROR Environment – Development and Validation (HEGEL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Netherlands,Netherlands,United Kingdom,United Kingdom
Call: High cycle fatigue prediction methodology for fiber reinforced laminates for aircraft structures in CROR environment – development and validation (H2020-CS2-CFP03-2016-01, 2016)
Start date: 2017-02-01
End date: 2020-01-31
Duration (months): 36.0
Total project cost (EUR): 399842.5
EU funding (EUR): 399842.5
Participants: 4
Project status: CLOSED

The aim is to develop high cycle fatigue (HCF) testing capabilities for composite materials to study the long-term fatigue life of composite laminates used in new structural architectures subjected to high sound pressure loading in CROR environment. The achievement of the overall project aim will be tackled through the accomplishment of two technical objectives: developing a sound source and amplification system representative of the high sound pressure generated by the CROR; developing and validating an enhanced accelerated fatigue prediction methodology framework to HCF life prediction of CFRP laminates used in the new aero-structures configurations in CROR environment. Concepts for the sound source and amplification system will be designed according to the specifications. The best concept will be demonstrated and validated and successively the system will be manufactured and delivered to Fraunhofer IBP. The development of the methodology framework for HCF prediction of CFRP materials will be achieved through extensive experimental testing, physical analysis and numerical FE modelling activities. Following on from existing approaches, the final outcome of the project will be an expanded methodology framework for HCF prediction of CFRP laminates able to take into account the influence of environmental conditions as well as the presence of frequency dependent phenomena (e.g self heating). The framework will consist of fatigue models based on fatigue master curves and shift as well as FE predictive models that can be used as virtual assessment tools for HCF performance of CFRP materials. The immediate impact of the project will be providing the IADP’s Partners and the aerospace community with advanced testing capabilities to facilitate the design process and the structural integrity assessment of the new aero-structure configurations as result of the CROR integration in order to meet safety and certification requirements.

Keywords: accelerate fatigue prediction,sound source,amplification system,cror sound pressure,high cycle fatigue,high frequency,high cycle fatigue numerical modelling
A uniQue platform enabling faster development of treatments for Rare Diseases (QRD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Netherlands
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Patient availability is one of the key elements associated with the successful execution of rare disease drug trials, and at the same time a major bottleneck that increases drug development time and cost. Patient recruitment is responsible for 25-30% of the total costs of a clinical trial, for adding substantially to the duration of a trial, and for the failure of 1 in 3 Phase 3 clinical trials. Decodeon aims to transform this bottleneck into a major node in the value chain by developing and deploying structured and efficient patient registries for pharma companies and Contract Research Organisations (CROs). In doing so, Decodeon aims to overhaul this major inefficiency in clinical trial management, while tapping into an unexplored market worth €2.5 billion. Currently, big pharma tenders clinical trials to CROs, who perform a trial for e.g. a lump sum. Decodeon will provide CROs with rare disease patients who have pre-consented with inclusion in a clinical trial, filtered based on the specific inclusion/exclusion criteria of the trial, and at the required numbers. As a consequence, CRO efficiency will increase, through lowering the time required for patient recruitment and the associated costs. Support for our novel platform is demonstrated through letters of support, annexed to this proposal.

Keywords: rare disease,patient registry,patient recruitment,clinical trial management
Histone modifying enzymes as direct regulators of metabolic reprogramming: Towards a New Paradigm (MetabolACE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Cyprus
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 145941.12
EU funding (EUR): 145941.12
Participants: 1
Project status: CLOSED

Accumulating evidence in recent years has highlighted strong regulatory interactions between epigenetic mechanisms and metabolic transformations, mainly through transcriptional control of key metabolic genes. However, what has been overlooked is the direct effect of histone modifying enzymes on cellular metabolism as they are large consumers of sentinel metabolites. Therefore, I hypothesize that histone modifying enzymes and their mediated post-translation modifications (PTMs) on histones directly drive metabolic rewiring which subsequently impacts various cellular processes including gene expression. Specifically, this fellowship will focus on histone acetyltransferases (HATs) that use acetyl coenzyme A (Acetyl-CoA) as their sole substrate. Using interdisciplinary, state-of-the-art approaches that integrate subcellular metabolomics and high-throughput epigenomic techniques I will interrogate how the activity of HATs controls the abundance of acetyl-CoA and, in turn, defines the metabolic status of a cell leading to a subsequent reciprocal effect on the epigenetic landscape and genome regulation. Firm preliminary data, that I have recently generated, support the proposed project hypothesis and demonstrate that the experimental design is credible. During this project, my in-depth knowledge of metabolism and mass spectrometry skills will be combined with the expertise of epigenetics and histone biology that I will acquire at the host lab to reveal a new pathway through which histone PTMs function. This work will unveil a new fundamental link between epigenetics and metabolism and will be the commencing point for important future work in health and disease. Importantly, this fellowship will propel my academic career and help me become a scientific leader at the interface of epigenetics and metabolism since it will act as a stepping stone towards securing new research funding and acquiring a tenure track position.

Keywords: metabolism,lipid metabolism,chromatin dynamics,histone modifications,epigenetics
The Making and Awaking of the European Far Right: A Qualitative Analysis of Far Right Supporters In Denmark and Poland (AWAKE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2025-07-16
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: SIGNED

This project will study the rise of far right parties and movements in Poland and Denmark. First, I will investigate the extent to which the far right’s growing support stems from some individuals adopting far right-wing ideologies (the making of new supporters), and from existing sympathizers becoming active in their support (the awakening of existing supporters). To do this, I will conduct in-depth interviews with far right supporters who voted for a far right party, whether right-wing populist or radical right, in either 2015, 2019, or both. An analysis of the informants’ life histories—specifically how their perceptions, values and behaviours fit into broader socio-political contexts—will improve contemporary understandings of the nature and causes of growing far right support. Second, I will examine how religion, gender and political opportunity structures contribute to the making or awakening of far right supporters. Specifically, by comparing the life histories, perceptions, values, and behaviour of far right supporters in two disparate settings—Denmark and Poland—I will examine how (1) the degree of national secularism/religiosity, and the structure of religious institutions to which religious supporters belong, (2) the strength of left-wing political alternatives, and the position of far right parties (majority/minority) in government, and (3) hegemonic conceptions of gender roles and norms, shape why and how far right supporters come to adopt far right ideologies, and why and when they choose to act on those ideals. Third, this project will provide important new evidence about the growth of far right support in a Central-Eastern European context, which has remained relatively understudied despite a significant rise of the far right.
Development, engineering, production and life-cycle management of improved FIBRE-based material solutions for structure and functional components of large offshore wind enerGY and tidal power platform (FIBREGY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Germany,Spain,Ireland,Germany,Spain,Spain,Norway,France,France,Denmark,Portugal
Call: Materials for off shore energy (IA) (H2020-NMBP-ST-IND-2020-twostage, 2020)
Start date: 2021-01-01
End date: 2024-04-30
Duration (months): 40.0
Total project cost (EUR): 8056482.5
EU funding (EUR): 6499589.75
Participants: 14
Project status: SIGNED

There is no doubt that the offshore renewable energy exploitation has a great potential to grow, and it will greatly help reach climate goals and CO2 reduction levels and are likely to secure Europe’s technical and economic competitiveness. However, the open sea is a very aggressive environment with may largely affect the maintenance costs of the installations and therefore the overall cost of offshore energy generation. The owners of offshore assets are well aware of that and are paying a steep price. A massive amount of steel goes into those assets, and all this metal is subject to degradation, which explains why corrosion accounts for approximately 60% of offshore maintenance cost. Preventive maintenance is not just expensive but also reduces the operating life of the assets. Despite the convenient immunity to corrosion of Fibre Reinforced Polymers (FRP), the use of those materials for large marine structures is limited to secondary components. The main objective of the FIBREGY project is to enable the extensive use of FRP materials in the structure of the next generation of large Renewable Energy Offshore Platforms (REOPs) by overcoming the above mentioned challenges. In order to achieve this objective, the project will develop, qualify and audit innovative FRP materials for offshore applications, elaborate new design procedures and guidelines, generate efficient production, inspection and monitoring methodologies, and validate and demonstrate advanced software analysis tools. Clear performance indicators will be designed and applied in the evaluation of two existing REOPs concepts to be re-engineered in FRP in the project. Finally, the different technologies generated in FIBREGY will be demonstrated by using advanced simulation techniques and building a real-scale prototype to validate the materials, tools, solutions, procedures and guidelines to be developed in FIBREGY.

Keywords: fibre reinforced polymers,offshore technology,immunity to corrosion,improved durability,lightweight structures,reduction of life cycle costs
Ethical Technology Adoption in Public Administration Services (ETAPAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Italy,Italy,Belgium,Sweden,Greece,Norway,Greece,Norway,France,France,Denmark
Call: Transformative impact of disruptive technologies in public services (H2020-SC6-TRANSFORMATIONS-2020, 2020)
Start date: 2020-11-01
End date: 2023-10-31
Duration (months): 36.0
Total project cost (EUR): 3292936.25
EU funding (EUR): 3292936.25
Participants: 15
Project status: SIGNED

Disruptive Technologies (DTs) have a great yet untapped potential to boost the developing of new and more efficient Public Services. Reasons entail resource shortage in terms of competences and infrastructures, but also resistance to and lack of trust in technology. Although a recent uptake of the topic of ethical, social and legal issues related to DTs, practical guidelines to fully assess the risks of adopting DTs in Public Administrations are still missing. The ETAPAS project aims at introducing a practical framework, supported by a prototypical software platform, to offer a first-time assessment methodology capable of measuring and mitigating ethical, societal and legal risks. The project will co-design with Public Bodies a framework consisting of ethical principles, a set of measurable indicators and a legal construct for the responsible adoption of DTs. The framework will be tested and validated on four use cases in which DTs are applied to face the challenges of the Italian Ministry of Finance, Don Gnocchi Foundation, and local municipalities in Norway and Greece. Use cases’ development, as well as exploitation and dissemination activities, will be strengthened by the engagement of two Digital Innovation Hubs and their network. This will ensure ETAPAS framework wide applicability to the European Public Sector and will prove in practice how DTs can support the realisation of responsible innovative solutions of Public Services. Lessons learnt and PAs’ feedback will feed into ETAPAS final output: a governance model to allow other public organisations to replicate the methodology and adopt innovative solutions while assessing, monitoring and mitigating associated risks. ETAPAS project aims at accelerating a responsible adoption of disruptive technologies in the delivery of Public Service so that Public Administrations can reduce management costs, improve service efficiency, securely manage data assets, and foster greater citizen trust and engagement.

Keywords: ethics of technology,risks of disruptive technologies,digital innovation in public services,digital governance,social impact of technologies,artificial intelligence,robotics,digital democracy
Division of labour and the origin of multicellularity (MULTICELL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2019-08-30
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Understanding the evolution of multicellularity and cellular differentiation/ complexity is one of the greatest challenges in biology. Of particular interest is to determine the evolutionary processes (selective causes) and mechanisms underlying the evolutionary transition from single cells to multicellular organisms. This project will use cyanobacteria as a model system to determine whether cellular differentiation is a cause or consequence of multicellularity. A novel theory will be tested, which predicts that the division of labour/ differentiation among cells drives the transition to a multicellular state. This will be contrasted with the classical view, where cellular specialization originates only at a much later state during the transition. The proposed project will adopt an interdisciplinary approach by combining experimental evolution (WP1) with phylogenomics (WP2). More specifically, populations of unicellular cyanobacteria will be subjected to long-term experimental evolution under two different regimes that favour either the specialization of cells into performing different physiologically incompatible processes, or the formation of non-differentiated aggregates (WP1). By linking the phenotype to the underlying genotype and to gene expression patterns, the critical steps for the transition to multicellularity will be established at the genome level. This evolutionary sequence will be directly compared to the one inferred from the cyanobacterial phylogeny (WP2). Here, whole genomes will be used to reconstruct the gain and loss events for the main ‘multicellular traits’, such as filament formation and cellular differentiation. The findings will not only provide insight into the key events during the transition to multicellularity but will also be the first study that directly relates a transition that was achieved under artificial conditions in the laboratory to one that actually happened more than 3 billion years ago in this phylum.

Keywords: experimental evolution,multicellularity,evolutionary transitions,division of labour,cyanobacteria,phylogenomics