Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Creation and promotion of Forest and Agriculture Networks to boost Bio-Based Technologies adoption and Value Chain development (BBioNets)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Ireland,Italy,Poland,Spain,Greece,Czechia
Call: Broaden EIP Operational Group outcomes across borders by means of thematic networks to compile and share knowledge ready for practice (HORIZON-CL6-2023-GOVERNANCE-01, 2023)
Start date: 2023-11-01
End date: 2026-10-31
Duration (months): 36.0
Total project cost (EUR): 2157716.0
EU funding (EUR): 1998636.2
Participants: 9
Project status: SIGNED

In response to the increasing need for grassroots initiatives and knowledge sharing to address major challenges such as climate resilience and increased mitigation of GHG emissions, while supporting zero waste and circular economy with biomass reuse, BBioNets will constitute a thematic network that will rely on, promote, and further advance the work carried out by EIP AGRI Operational Groups (OGs) with respect to management and/or processing of agricultural and forest biomass with Bio-Based Technologies (BBTs). Applying the quintuple helix model and a multi-actor approach both within the consortium itself and on the ground activities, BBioNets will set up 6 regional Forest and Agriculture Networks - FANs (IE, ES, IT, GR, PL, CZ) that will ensure balanced representation of all AKIS stakeholders. FANs will identify local needs and, through co-creation and joint actions, prioritise specific BBTs, benefit from and validate knowledge material developed by the consortium building on previous OG and EU-funded project results. They will assist BBioNets in sharing BBT knowledge ready for practice to farmers and foresters, boosting the (re)definition of value chains, stimulating cross-fertilisation beyond borders, and bringing Europe to the forefront of farming, forestry, and bioeconomy with economically viable and sustainable practices. BBioNets’s solid foundation and strength lies in its partners’ a) wide networks covering the Agriculture, Forestry and Bioeconomy world, b) long-established collaborations with OGs, c) extensive knowledge of bio-based technologies and solutions and d) long experience in awareness raising, knowledge transfer, capacity building, networking and value chain creation services.

Keywords: bioeconomy,bio based technologies,education,training,farmers,foresters,eip agri,operational groups,
Switching-Cell-Array-based Power Electronics conversion for future electric vehicles (SCAPE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Partnership: 2ZERO (co-programmed)
Countries involved: Spain,Italy,Türkiye,Germany,France
Call: Nextgen EV components: Integration of advanced power electronics and associated controls (2ZERO) (HORIZON-CL5-2021-D5-01, 2021)
Start date: 2022-07-01
End date: 2026-06-30
Duration (months): 48.0
Total project cost (EUR): 5999750.0
EU funding (EUR): 5999750.0
Participants: 10
Project status: SIGNED

In power electronics, the traditional design approach of power converters involves a range of power semiconductor devices with different ratings, optimized to operate at different conditions, where different suitable ancillary circuitry and power circuit topologies are also required. This dispersion in power devices and circuits leads to significant engineering efforts, the inability to take full advantage from scale economies to reduce costs, and the inability to concentrate efforts to improve performance. In the electric vehicle (EV) market, this is translated to a lack of standardization on the EV power conversion system designs across the different models and types of vehicles available, meaning that nowadays EV OEMs invest billions of euros to develop their own solutions. SCAPE aims at achieving three main objectives: i) propose a standardisable, modular, and scalable approach, based on multilevel technology, for the design of the EV power conversion systems ii) develop highly-compact and integrated building-block implementation. iii) propose intelligent modulation and control strategies, online diagnosis, and digital twin for predictive maintenance with machine learning. Reaching these objectives will enable reducing the cost of the EV power electronics thanks to scale economies, improving its performance features (reliability, efficiency, power density, etc.), and enabling advanced functionalities. This will allow satisfying the user’s needs, increase the acceptance and affordability of zero-emission vehicles, reduce green-house gasses emission, and enable a full-market penetration of the EV. Having this approach adopted by EU automotive manufacturers will allow creating a cost-efficient production chain in the EU based on economies of scale and advanced integration technologies, as a competitive advantage against other manufacturers.

Keywords: power electronics,multilevel converters,board integration
BUILDING A SUSTAINABLE EUROPEAN INNOVATION PLATFORM TO ENHANCE THE REPURPOSING OF MEDICINES FOR ALL (REMEDi4ALL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Netherlands,Germany,Finland,France,Italy,Spain,United Kingdom,Belgium,Hungary,Sweden,Slovenia
Call: Building a European innovation platform for the repurposing of medicinal products (HORIZON-HLTH-2021-DISEASE-04, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 22561532.0
EU funding (EUR): 22561532.0
Participants: 28
Project status: SIGNED

REMEDi4ALL aims to establish Europe's leadership globally in the repurposing of medicines by creating a vibrant community of practice covering all relevant sectors and disciplines. REMEDi4ALL will establish and operate a permanent European research and innovation platform comprising the complete value chain for cutting edge, patient-focused repurposing, collaborating with users to execute high potential projects at any phase of development, upskilling all stakeholder groups through a comprehensive education and training portfolio, and advancing cross-sectoral policy dialogue with all relevant stakeholders and thought leaders. The tools and processes developed assembled in REMEDi4ALL will be validated in a portfolio of 4 ambitious preclinical and clinical phase demonstrators, representing high patient need in a variety of disease areas, including oncology, rare and infectious diseases. The REMEDi4ALL platform will operate a complete, harmonised and accessible value chain integrating the scientific, methodological, financial, legal, regulatory, and intellectual property aspects of the repurposing approach in a goal-oriented and patient-centric approach. Working closely together with research funders and the patient community, REMEDi4ALL will engage and support a substantial user base and concomitant investments through a permanently sustainable entity, working closely with the permanent European Infrastructures and partners. The community of practice comprises leading academic and clinical facilities and infrastructures, medicines regulators, health technology assessors, public agencies and funders, small and large industry, state-of-the-art artificial intelligence and in silico tools, and a global network of collaborators for optimal knowledge exchange. REMEDi4ALL will substantially increase Europe's capacity to develop high quality repurposed medicines and implement them into the market, through its complete value chain and consensus-based policy development mission.

Keywords: drug repurposing platform,medicines repositioning,patient centric randi,repurposing policy
Spatiotemporal coordination of microtubule-organizing centers in two evolutionary distant eukaryotes (MTOControl)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-15
End date: 2025-05-14
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Microtubule-organizing centers (MTOCs) are key eukaryotic structures for microtubule nucleation and organization. Many MTOCs contain centrioles, organelles with two critical functions. i) In mitosis, they localize to the pole of the mitotic spindle aiding its organization. ii) After cell division, centrioles are repurposed as basal bodies at the plasma membrane where they are essential for cilia/flagella formation. Defects in centriole/basal body (CBB) repurposing can have devastating consequences and lead e.g. to infertility in human sperm. CBB functions correlate with subcellular localization, but is the spatiotemporal control required for this organelle to fulfill two distinct functions? How did the ancestral CBB evolve these functions? And why are different MTOCs not present simultaneously in a cell? To tackle these questions, I will first analyze and compare CBB repurposing strategies during the cell cycle of the green alga Chlamydomonas rheinhardtii with those in the complex life cycle of the acellular slime mold Physarum polycephalum, two evolutionary distant eukaryotes. To do so, I will develop and apply a correlative microscopy workflow in which time-lapse imaging of cells is followed by cryo-fixation and expansion microscopy (Cryo-ExM) combined with Stimulated Emission Depletion (STED). Using transient overexpression and laser ablation, I will interfere with spatial and temporal control of CBB repurposing to elucidate the role of subcellular location of this bifunctional organelle. Further, I will study how cells cope with several different MTOCs at a time, likely competing for tubulin. This project will provide a novel, high-end correlative live-cell and super-resolution imaging pipeline, which can be easily adapted for various species and cellular structures. Understanding the different strategies of CBB repurposing that evolved will have broad implications as a basis to understand CBB defects in the human cell cycle and during spermatogenesis.

Keywords: microtubule organizing center,centriole,basal body,centrosome,flagella,cilia,cell cycle,division,open mitosis,closed mitosis
Arrowhead Flexible Production Value Networks (Arrowhead FPVN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: Sweden,Hungary,Portugal,Austria,Finland,Italy,Spain,Denmark,France,Romania,Norway
Call: General according to ECS-SRIA 2022 (IA) (HORIZON-KDT-JU-2022-1-IA, 2022)
Start date: 2023-06-01
End date: 2026-08-31
Duration (months): 39.0
Total project cost (EUR): 25518769.5
EU funding (EUR): 7011940.14
Participants: 46
Project status: SIGNED

The Ambition for Arrowhead fPVN project is Doubling of the European industrial productivity by applying transformative, autonomous and evolvable information interoperability for resilient and adaptive production value networks. Hence, the Arrowhead flexible Production Value Network (fPVN) project will provide autonomous and evolvable interoperability of information through machine-interpretable content for fPVN stakeholders. The resulting technology is projected to substantially impact manufacturing productivity and flexibility. Autonomous and evolvable interoperability will be achieved through common project technology based on three pillars: 1. Microservices paradigm, 2. Utilization of major industrially accepted data models, 3. Automatic translation between the data models. The common technology will be validated and verified in 11 use cases covering the production value networks in the following industrial production domains: • Semiconductor production, • Automotive services, • Aerospace services, • Green energy conversion, and • Process industry production. The results are expected to considerably impact the efficiency of both local and global production value networks thanks to substantial cost and time reduction for setting up, operating, and managing the interactions within production value.

Keywords: interoperability,autonomous translation,information models,micro services,semiconductor,automotive,aerospace,energy,process industry,productivity
Unraveling the link between microbial biogeochemical cycles and mercury transformations in oxygen-depleted submarine groundwater discharges (MIMOA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2026-06-30
Duration (months): 30.0
Total project cost (EUR): 206641.2
EU funding (EUR): 206641.2
Participants: 4
Project status: SIGNED

Coastal aquifers are sensitive land-ocean transitional zones receiving nutrient-rich water due mainly to fertilizing practices that may increase microbial activity and reduce oxygen (O2) availability. The diverse microbial communities inhabiting these systems may have a crucial role in biogeochemical cycles including metal transformations such as mercury (Hg). Yet, the factors determining the microbial Hg transformations in coastal aquifers is poorly understood. The increasing depletion of O2 in coastal waters from submarine groundwater discharges (SGDs) may modify the biogeochemical processes and hence modulates the Hg speciation and its export to the sea. To shed light on this, the MIMOA project aims at defining the role of nutrient-enriched SGDs in microbial Hg cycling of coastal areas by combining microbial, chemical, and educative dimensions. This project will rely on the synergy of my background in biogeochemical cycles and anoxic environments with extensive expertise in Hg biogeochemistry and metagenomics of the host (Dr. Bravo). This will be complemented by the essential expertise in biochemistry of low O2 zones and analytic/environmental chemistry of the two secondment supervisors (Dr. Garcia-Robledo and Dr. Amouroux). By getting trained in bioinformatic analyses, gene detection and chemistry, I will explore the effects of O2 depletion from SGDs on microbial Hg transformations in an eutrophication context and transfer this knowledge to the general audience through science outreach and education assisted by Plàncton company as a placement. MIMOA outcomes will significantly contribute to global Hg budget by revealing the importance of Hg export through depleted O2 SGDs, having long-term consequences on marine food web contamination and improve awareness of general audience on their anthropic footprint in coastal zone; boosting my career opportunities as a prominent researcher in microbial ecology and biogeochemistry, after my research period in Latin America.

Keywords: mercury,methylmercury,submarine groundwater discharge,oxygen depletion,microbial ecology,eutrophication,coastal conservation,environmental education,nitrogen,methane,sulfur,iron
Advanced High Pressure and Cost-Effective PEM Water Electrolysis Technology (ADVANCEPEM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Italy,France,Denmark,Germany,United Kingdom
Call: Development of low temperature water electrolysers for highly pressurised hydrogen production (HORIZON-JTI-CLEANH2-2022-1, 2022)
Start date: 2023-02-01
End date: 2027-01-31
Duration (months): 48.0
Total project cost (EUR): 1631066.56
EU funding (EUR): 1607330.0
Participants: 11
Project status: SIGNED

Direct production of highly pressurised hydrogen from electrolytic water splitting can allow saving relevant amounts of energy compared to down-stream gas compression. The aim of this project is to develop a novel polymer electrolyte membrane (PEM) electrolyser able to produce hydrogen at very high pressure (200 bar) thus reducing the post-compression energy consumption. Another goal is to develop a cost-effective technology allowing to achieve large-scale application of PEM electrolysers. A significant reduction of capital costs is achieved by critical raw materials minimisation, developing cheap coated bipolar plates and operating the electrolyser at a high production rate while assuring high efficiency (about 80% vs. HHV) and safe operation. ADVANCEPEM aims at developing a set of breakthrough solutions at materials, stack and system levels to increase hydrogen pressure to 200 bar and current density to 5 A cm-2 for the base load, while keeping the nominal energy consumption <50 kWh/kg H2. Reinforced Aquivion® polymer membranes with enhanced conductivity, high glass transition temperature and increased crystallinity, able to withstand high differential pressures, are developed for this application. The approach is to operate the innovative membrane at high temperature 90-120 °C under high pressure to allow increasing energy efficiency. To mitigate hydrogen permeation to the anode and related safety issues, efficient recombination catalysts are integrated both in the membrane and anode structure. The new technology is validated by demonstrating a high-pressure electrolyser of 50 kW nominal capacity with a production rate of about 24 kg H2/day in an industrial environment. The project will deliver a techno-economic analysis to assess reduction of the electrolyser CAPEX and OPEX. The consortium comprises an electrolyser manufacturer, membrane and catalyst supplier, an MEA developer and an end-user for demonstrating the system.

Keywords: hydrogen,electrolysis,high pressure,polymer electrolyte membrane,high current density,reinforced membrane
European Network Against Crime and Terrorism (ENACT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Strengthened Security Research and Innovation
Action type: Coordination and support actions
Countries involved: Portugal,Spain,Finland,France,Netherlands,Italy,Belgium,United Kingdom,Greece
Call: Knowledge Networks for security Research & Innovation (HORIZON-CL3-2022-SSRI-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 2021811.99
EU funding (EUR): 1912794.13
Participants: 12
Project status: SIGNED

The programming of Security R&I is a highly sensitive exercise which has grown in complexity during the past years. Moreover, the uptake of innovation stemming from EU-funded security R&I projects remains a challenge. The goal of ENACT is to set up a Knowledge Network for Security R&I in the Fighting Crime and Terrorism area capable of i) supporting the EU-funded FCT security R&I cycle and the overall community and market actors with actionable evidence, and ii) boosting the Innovation Uptake of the outcomes and results stemming from FCT Security funded R&I projects. ENACT brings together the most unique blend of knowledge, background, skills, resources and connections to: i) deliver a network-enabling service that facilitates the exchange of knowledge and value within the wider FCT community; ii) catalogue, aggregate and exploit the existing knowledge on the FCT area ensuring continuous availability of a structured knowledge base accessible to decision makers of the various R&I domains; iii) communicate project activities and disseminate & exploit project findings in a timely manner, ensuring continuous availability of updated actionable knowledge in each of the four domains addressed, namely capabilities, technology, market and SSH; iv) foster cooperation between FCT market actors in order to improve the market visibility and the uptake of innovation, and; v) ensure the sustainability of the “knowledge as a service” model and the enabled networking environment beyond the project duration. To operationalise these five pillars, ENACT will implement coordination and support measures to extract information from the FCT R&I Community making use of the project’s connections with specific Knowledge Hubs. It will also classify the information according to a recognisable taxonomy, define concrete metrics, derive results based on the exploitation of the acquired information and feed them back into the community, thus contributing to a more impactful EU FCT R&I effort.

Keywords: networking ceris observatory cooperation taxonomy eu security market innovation uptake organised crime terrorism and radicalisation cybercrime forensics ai policy feedback
Protein-RNA interaction stabilization using molecular glues (PRIGLUE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: SIGNED

Protein-RNA interactions play a key role in cell biology and there are limited tools for specific modulation. In this project we will look for molecules that act as glues by stabilizing the interaction between an RNA-binding protein and a specific RNA sequence which we call PRIGLUEs. The aims are to explore key concepts of how to develop screening methods to identify such PRIGLUEs and to determine what type of chemical matter is suitable for this approach. These novel molecular glues will be evaluated for their RNA selectivity and the mode of interaction stabilization. The methods we will develop to identify PRIGLUEs can be applied to any protein-RNA interaction, and we will use them to modulate the process of mRNA splicing to prove the concept. The glues will be applied to stabilize mutant splicing factor – RNA pairs to recover lost affinity and correct disease-causing splicing outcomes. PRIGLUEs will be applicable as novel tools for RNA biology studies but can eventually also lead to therapeutics with an unexplored mode of action.

Keywords: molecular glues,protein rna interactions,splicing