Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Multi-hazard low-carbon resilient technologies and multi-scale digital services for a future-proof, sustainable & user-centred built environment (MULTICARE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Partnership: B4P (co-programmed)
Countries involved: Netherlands,Germany,Ireland,Romania,Italy,Poland
Call: Designs, materials and solutions to improve resilience, preparedness & responsiveness of the built environment for climate adaptation (Built4People) (HORIZON-CL5-2022-D4-02, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 9298465.22
EU funding (EUR): 7497153.28
Participants: 21
Project status: SIGNED

The built environment is ill-prepared for more frequent and increasingly intense climate-related extreme events. These cause severe socio-economic losses and adversely affects public health. Recent scientific and technological advances in the construction industry provide timely solutions for improving the resilience of buildings for specific hazards, but these are often not cost effective or eco-friendly. There is a lack of frameworks for assessing the climate resilience, making it challenging to develop optimal solutions for multi-hazard scenarios. MULTICARE will address this challenge by developing innovative multi-criteria decision-support frameworks and providing plug & play low-carbon resilient technologies for improving the multi-hazard resilience of our built environment in a cost-effective, reliable and sustainable manner. A suite of multi-disciplinary digital services and tools will be developed for multi-hazard resilience assessment, design, operation and management across multiple scales (material, component, building, neighbourhood/district). This will enable stakeholders to make more informed decisions to select materials/solutions and build resilient supply chains, even in case of cultural heritage buildings. We will demonstrate our results in large-scale pilots (3 buildings, 4 neighbourhoods/cities) in different countries with diverse conditions. A user-centred, inclusive and participatory approach will be consistently implemented at all stages of the project for citizens engagement and for extending the durability of MULTICARE impact. To achieve the project goals, MULTICARE combines 21 partners covering the whole technical value chain required for solutions in resilient and sustainable buildings. The Consortium includes experience in social sciences, user engagement and training. The Consortium will support clustering activities with other projects aimed at sharing knowledge, experience, and raising public awareness of climate resilience.

Keywords: resilience,multi hazard,low carbon,low damage,resource efficient,facades,multi criteria decision making,digital services,interoperability,user centred
Pan-European Food Systems Science Network (FoSSNet)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: Denmark,Netherlands,Belgium,Germany,France,Portugal,Poland,United Kingdom,Italy,Sweden,Latvia,Spain
Call: Developing an interdisciplinary and inclusive pan-European academic network for food system science (HORIZON-CL6-2023-GOVERNANCE-01, 2023)
Start date: 2024-02-01
End date: 2028-01-31
Duration (months): 48.0
Total project cost (EUR): 5521185.0
EU funding (EUR): 5521184.25
Participants: 15
Project status: SIGNED

The vision of FoSSNet is a strengthened and deepened academic network to support a new Knowledge and Innovation governance structure for Europe’s food system. A new structure is needed as the current Knowledge and Innovation system in the European Research Area is insufficient to address the emerging challenges of nourishing the European food system in a healthy, sustainable and fair way. The aim of FoSSNet is twofold, on one hand to establish a permanent pan-European network for Food System Science and on the other hand to advance inter- and transdisciplinary Food System Science and education. This will contribute directly to the farm to fork objectives and FOOD2030 priorities. Developing the network and advancing Food Systems Science and education will be underpinned by an inclusive approach to ensure engagement of all relevant disciplines, researchers and non-academic actors in advancing Food System Science. In order to reach the vision and aim, FoSSNet will 1) develop a conceptual framework and a process for developing food system transformation pathways to create a common language and understanding among food system thinkers, 2) establish, mobilise and consolidate an inclusive inter- and transdisciplinary pan-European academic network for food systems science to bring European food systems scientists and the science institutions together, 3) enhance inclusivity of the Knowledge and Innovation system for a sustainability transformation of EU food systems by addressing sensitivities to power relations and inequities that pervade food systems and contested transformation processes, 4) co-produce research for sustainable food system transformation to remove existing barriers to interdisciplinarity in food system science, 5) build food systems capability through an academy and curricula to ensure the impact of future food system thinkers and 6) create scientific, economic and societal impact by ensuring sustainability of the network.

Keywords: food systems,food systems science,transition,sustainability,inclusivity,fokis,knowledge and innovation systems
Multilingual Acquisition and Processing: Heritage Russian in Spain (MAP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway,Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 2
Project status: SIGNED

Recent research highlights a need of deeper understanding of the nature of language competence and the development of this competence under heritage language bi- and multilingualism. Heritage speakers (HSs) is a population highly diverse in terms of their linguistic competence and its development. Multilingual Acquisition and Processing (MAP): Heritage Russian in Spain will provide an examination of Russian Heritage Language (HL) grammar in a previously unstudied socio-linguistic context focusing in particular on the patterns of cross-linguistic interaction at early and most unstable stages of multilingual language development. The overall research objective is to discover the patterns of language acquisition and language processing in order to find out how multilingual minds deploy their developing grammatical knowledge and how they detect and access the linguistic (morpho-syntactic) mechanisms from their two co-existing languages in real-time. The proposed empirical study will investigate the effects of linguistic proximity, individual experiential factors and the developmental patterns of cross-linguistic influence in child bilingualism. Heritage Russian in Spain will be studied with a focus on 3-7-year-old children in order to examine developmental trajectories in both languages. On the theoretical level, MAP will significantly contribute to the development of a model of heritage language grammar and add to a sub-field of multilingualism studies, Heritage Language Acquisition, by showing the patterns of cross-linguistic interaction at early stages of multilingual Russian-Spanish development. On a societal and education level, project findings will be relevant for policy makers, teachers, school principals and HSs communities in European countries. To date, most heritage language studies have focused exclusively on the minority language, MAP will fill an important gap by focusing on both languages.

Keywords: multilingualism,heritage language acquisition,cross linguistic influence,comprehension,production,online processing,russian,spanish
Machine learning algorithm pipeline for endothelial damage detection and adverse outcome prediction. (MACLEA-ENDO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

Endothelial cells form the lining of the blood vessels of the entire vascular system, from the heart to the smallest capillary, regulating vascular tone, immune response and exchange of materials in and out the blood stream among others. Endothelial damage has been observed in the early stages of most cardiovascular diseases, atherosclerosis or in patients with iflammatory and infectious diseases (e.g. COVID-19, septic shock). Typically endothelial damage is measured by means of blood test analysis and provocative tests either invasive, performed by using pharmacological agents, or non-invasive, such as flow mediated dilation that on the other hand, suffer from high operator-independency and no-automatization. This proposal revolves around the design, development and validation of a supervised machine learning algorithm (ML) to evaluate endothelial damage and predict adverse outcome in critically ill patients in the ICU. The ML pipeline will use as input data the one from the Horizon 2020 project VASCOVID clinical validation. These data comprises of physiologically relevant variables that can be measured non-invasively with a completely automatized platform. This smart platform combines diffuse optics and an automatized tourniquet for performing a reactive test on peripheral muscle (thenar muscle). By means of this device it is possible to access in an accurate and robust way information about early impairment in perfusion, metabolic rate of oxygen consumption, and microvascular functionality and tissue capability of locally regulate the blood flow. These variables bring an important physiological insight concerning the interpretability of machine learning algorithm from the clinical community who does not fully trust this approaches.

Keywords: supervised machine learning,diffuse optics,endothelial damage,sepsis,covid 19,endothelial therapies
Redox-driven Switches and Motors (RedSwiMot)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

Artificial molecular machines can not only exploit rotary or linear molecular motion to perform useful functions, but can also elucidate the operational principles of Nature´s biomolecular analogues, which underpin a myriad of crucial biochemical processes. Electrochemically controlling these systems is a particularly promising approach to achieve a high degree of (spatial) control, reusability, sustainability and ease of interfacing with existing electrical (nano)technologies and can furthermore be utilised in solid materials or gels. In spite of these advantages, they remain considerably underexplored. In this MSCA-PF action, we aim to address this challenge in developing redox-driven conformational switches based on the overcrowded alkene bisthioxanthylidine (BTX). As a result of their synthetic adaptability, and versatile multistate switching properties, redox-driven BTX rotors are ideally suited to complement, or even surpass, the ubiquitous light-driven overcrowded alkene motors, particularly in opaque and interfacial environments. In order to develop this capability we propose the first systematic investigation into both the fundamental redox-switching properties of BTX derivatives and also, for the first time, demonstrate their utility in various proof-of-principle applications, including switchable ion-recognition and stimuli-responsive interfaces. This work will furthermore lay the foundation for the development of the first, true unidirectional-redox driven overcrowded alkene motors, a long sought-after, but thus far elusive, goal. These pioneering efforts will not only provide invaluable insights into the operational principles of redox switches, and molecular machines in general, but will also pave the way towards their exploitation in numerous industrial, biomedical and environmental applications, especially where light-driven systems are not applicable.

Keywords: electrochemistry,surface modification,artificial molecular machines,redox switches,overcrowded alkenes,bisthioxanthylidenes,monolayers,ion recognition,wettability
EARLY DETECTION AND INTERVENTION IN SMOLDERING MULTIPLE MYELOMA: POPULATION-BASED SCREENING AND TREATMENT (Edit-SMM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Iceland
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 1998145.0
EU funding (EUR): 1998145.0
Participants: 1
Project status: SIGNED

Multiple myeloma (MM) is a bone marrow malignancy that is always preceded by asymptomatic precursor conditions, monoclonal gammopathy of undetermined significance (MGUS) or smoldering MM (SMM). SMM is a more advanced precursor and is associated with a high risk of progression to MM. More than 94% of MM cases are diagnosed when already at the stage of full-blown malignancy and therefore do not benefit from the impact of early treatment. Recent studies indicate a benefit of early treatment but all prior SMM studies are based on patients diagnosed due to other medical issues and are therefore biased. There are important and urgent questions on the role of screening and early treatment in SMM. There is also an unmet need to develop a risk score for progression that considers the biology and genetics of the disease. In Edit-SMM we plan to build on the success from the Iceland Screens, Treats, or Prevents MM (iStopMM) study, where remarkably over 54% of the population (N=80,759) consented to a nationwide screening for MM precursors. It includes clinical evaluation and follow-up, biobanking, cross linking to central health data registries, repeated questionnaires on patient reported outcomes, groundbreaking methods of detection of SMM, and in-depth genetics. Edit-SMM will identify all patients with SMM diagnosed in iStopMM. These will be followed and treated with the global objective of inducing a paradigm shift by improving diagnostics, disease classification, and population implementation of early intervention in MM by detecting and treating MM at a precursor state, hopefully leading to improved quality of life and potentially a cure. The main objectives are to gather knowledge on the epidemiological, clinical, and patient reported outcomes of SMM, perform a unique nationwide early treatment trial, and leverage this unparalleled collection of samples to make major new discoveries on the biology and evolution of SMM.

Keywords: smoldering multiple myeloma,mgus,multiple myeloma,screening,randomized clinical trial,patient reported outcomes,population based,flow cytometry,cancer,genetics,phase 2 trial,epidemiology
Approaching 20% emission efficiency in the NIR-II region with radical chromophores (ARCHIMEDES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Poland
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2499825.0
EU funding (EUR): 2499825.0
Participants: 1
Project status: SIGNED

The applications of light-based technologies in modern society cannot be underestimated. Some well-known examples of these include organic light-emitting diodes, fluorescent sensors, organic photovoltaics and fluorescence imaging. Emissive radicals have recently appeared as promising and entirely new building blocks for these technologies. This breakthrough is due to the fact that their electron spins at the lowest excited state and ground state are both doublets and the transition from the lowest excited state to the ground state is not hindered by being a spin-forbidden reaction which allows for higher operational efficiencies. Additionally, compared with both classical fluorescence microscopy and infrared imaging methods (750-900 nm), imaging in the second near-infrared window (NIR-II, 1000-1700 nm) allows for both deeper tissue penetration and a higher signal-to-noise ratio. The applicability of NIR-II emitters can be bolstered through combination with circularly polarized luminescence (CPL, the differential emission of left and right polarized light). The overarching goal of this project is to uncover a strategy to create radicals which at the same time: (a) strongly emit light in the NIR-II region; (b) are stable under ambient conditions; (c) strongly absorb light; (d) display large circularly polarized luminescence. The primary objective of ARCHIMEDES is to deliver breakthrough organic materials possessing large fluorescence quantum yields and stable radical structures in the integrated fields of molecular design, chromophore synthesis and fluorescence imaging of living cells. The realization of ARCHIMEDES will be based on both expanding the chemical space of stable, emissive C-centered radicals and on heretofore nonexisting emissive nitroxide radicals. The synergistic effects of increased brightness of NIR-II dyes and the higher sensitivity and resolution offered by CPL fluorophores will provide quality fluorescence imaging on a previously unthinkable level.

Keywords: synthesis,fluorescence,radicals,dyes,chirality,helicenes
EUCYS Leiden2022 (EUCYS2022)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Other ERA
Destination: Other ERA
Action type: Coordination and support actions
Countries involved: Netherlands
Call: European Union Contest for Young Scientists (EUCYS) 2022 (HORIZON-WIDERA-2021-EUCYS-IBA, 2021)
Start date: 2021-09-01
End date: 2023-02-28
Duration (months): 18.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

The main objective of this Proposal is the organisation of the Young Talents Programme which contains two separate events. The first is the European Union Contest for Young Scientists (EUCYS) 2022. The second is the development of a pilot for next stage researchers & early career researchers with the working title EU TALENTON. Both events will be organized and held in Leiden, the Netherlands. Stichting Leiden European City of Science 2022 (Leiden2022) will be responsible for the organisation of the Young Talents Programme. The primary aim of the EU Contest for Young Scientists is to stimulate exchanges between talented young scientists, ensure that young scientists get guidance from some of the most prominent scientists in Europe and eventually to highlight scientific student achievements and attract widespread media interest. In other words, providing additional stimulus to young people who have an already demonstrated interest in applying science to solve problems. In the 2022 edition, Leiden aims to innovate the existing EUCYS model in several ways. into a more attractive contest. Leiden2022 aims to innovate EUCYS2022 in the following ways: - Reviewing the EUCYS award system - Researching if the scope of EUCYS can be expanded towards components of the Humanities (from STEM to STEAM) - Embedding EUCYS into the public and scientific programme of Leiden European City of Science 2022 Furthermore Leiden2022 aims to reach a more mature target group that is entering the next level of their research career by organizing a pilot. With this pilots Leiden2022 will explore the possibilities for organizing the EU TALENTON, and as such create a (potential) blueprint for EU TALENTON editions to follow. Therefore, EUCYS2022 and the EU TALENTON 2022 have the potential to have long lasting impact on the future of the Young Talents Programme. With this new approach, a broader group of young people will be attracted to (academic) careers in STEM and/or STEAM fields. By giving special attention to future prospects of participants and competition winners both within and outside of academics, The Young Talents Programme is more than a scientific competition alone as it creates a broad career perspective for young students and next stage and early career researchers ranging in age between 14 and presumably 24. Therefore, the Young Talents Programme is an instrument to achieve broader impact on young talent and society beyond the competitions itself (and the events connected to it).