Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Structure determination of human and chimpanzee HAR1F RNA by NMR (HAR1MC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-07-01
End date: 2012-06-30
Duration (months): 24.0
Total project cost (EUR): 168969.0
EU funding (EUR): 168969.0
Participants: 1
Project status: CLOSED

The 118-nt long human accelerated region 1 of humans (hHAR1F) possesses the largest genetic drift of all 49 so far identified HARs with an estimated 18 substitutions in comparison to the homologous sequence from the chimpanzee (cHAR1F). In order to understand the unknown function of these non-coding RNAs in the development of human consciousness it is essential to elucidate their secondary and tertiary structures of the HAR RNA with atomic resolution. We will design RNA constructs which will mimic sub-domains of the whole cHAR1F and hHAR1F regions. Afterwards we will biochemically prepare these RNA constructs. On the basis of NMR spectroscopic investigations of these RNAs (resonance assignment, measurement of RDC data, 13C-relaxation and relaxation dispersion) we will determine models for the tertiary structures and study their dynamics. Individual mutations of the cHAR1F sequence toward the human sequence will give information, which of the 18 substitutions triggers the change in conformation found in hHAR1F RNA. The knowledge of the functions of the cHAR1F and hHAR1F RNA could give an explanation about the cerebral cortex development of humans in comparison to that of the chimpanzee and make a contribution to understanding which determinants are characteristic for the humans.

Keywords: brain development,human accelerated region 1 rna,non-coding rna,rna structure,nmr,structural chemistry,organic chemistry,molecular chemistry
“Getting energy from Russia to Europe : Domestic political conditions in the energy-poor transit states of the former USSR and risks to energy transit to the European Union" (GETTING ENERGY TO EU)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2010-05-15
End date: 2011-09-14
Duration (months): 16.0
Total project cost (EUR): 159861.33
EU funding (EUR): 159861.33
Participants: 1
Project status: CLOSED

The objective of this project is to develop the synergies between the applicant’s unique expertise on the energy-poor transit states of the Former Soviet Union (FSU), the intellectual and organizational resources of the Aleksanteri Institute as a rising center for Russian and Eastern European energy research, and the applicant’s extensive international academic network with the goal of creating new knowledge on the domestic politics of the energy-poor transit states of the FSU and their effects on EU energy security. To reach EU markets, oil and gas from Russia must transit through countries such as Ukraine and Belarus, whose unstable relationship with Russia has created risks for Europe’s energy security. These countries are also highly dependent on Russian energy, and states where energy and politics have been strongly intertwined. Yet we lack detailed knowledge about the ways in which domestic political factors affect their energy policies and energy transit relationship with Russia. This project seeks to fill this gap by analyzing the domestic political determinants of energy and transit policies in four energy-poor states, each also playing a role in the direct or indirect transit of Russian energy to the EU: Ukraine, Belarus, Lithuania and Moldova. The project complements the strengths of the Aleksanteri Institute’s Eurasia Energy Group (which focuses mainly on the energy-rich FSU states such as Russia and Azerbaijan) by adding to it in-depth expertise on the energy-poor transit states. Central to the project is knowledge transfer to and from, and extensive discussions with, the Aleksanteri Institute and its academic networks in Finland and beyond, bringing added value to the European Research Area. Deliverables consist of a set of closely-related publications on the domestic political conditionants of energy policy in the energy-poor transit states, and a set of outreach activities aimed at European academic researchers, as well as policy-makers.

Keywords: political sciences,international relations,energy policy,energy transit,russia,ukraine,belarus,lithuania,moldova,eastern partnership,energy-poor states,security of energy supply
Control, Dynamics and Stochastics (CONDYS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2011-01-31
End date: 2013-01-30
Duration (months): 24.0
Total project cost (EUR): 225227.2
EU funding (EUR): 225227.2
Participants: 1
Project status: CLOSED

This proposal addresses the fundamental development of the analysis of control and random dynamical systems from a deterministic dynamical systems point of view. We are interested in developing three directions: 1. The theory of set-valued dynamical systems as a unified framework to analyse control and random dynamical systems. 2. Developing tools to analyse random dynamical systems. The first problem is to define and classify bifurcations for random dynamical systems using control-theoretic tools. A second problem is to prove ergodicity for infinite-dimensional random dynamical systems. 3. Analysing and controlling systems with structure and symmetries.

Keywords: autonomous dynamical systems,random dynamical systems,control systems,bifurcations
Integrative water sampling for the detection and identification of antiandrogenic contaminants in European rivers. (EDCSANTIANDROGENS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-04-12
End date: 2012-04-11
Duration (months): 24.0
Total project cost (EUR): 172240.8
EU funding (EUR): 172240.8
Participants: 1
Project status: CLOSED

Endocrine disrupting chemicals (EDCs) are environmental contaminants which have the potential to disrupt the normal functioning of the neuroendocrine system in animals and so result in physiological dysfunction. The effects of EDCs on wildlife and their potential effects on human health are a major concern to the scientific community and public. In Europe, EDCs with estrogenic activity are prevalent in effluents from wastewater treatment works (WwTWs), and may result in feminization of male fish in downstream waters reducing their fertility. Most recently, studies have shown that WwTWs effluents contain high concentrations of antiandrogenic activity, but unlike estrogenic chemicals, the identity of the antiandrogenic contaminants is currently unknown. This project aims to identify the antiandrogenic contaminants in WwTWs effluents using passive sampling techniques to obtain an integrative extract of contaminated waters over time. Antiandrogens in effluent extracts will be identified by bioassay-directed fractionation using a combination of in vitro androgen receptor assays and mass spectrometry analyses. Once identified, the range of concentrations of key antiandrogenic chemicals in river waters will be determined using integrative passive sampling of sites upstream and downstream of effluent discharges. This project will provide a more informed knowledge of the range of EDCs in river waters. The work will contribute to environmental impact assessments of these new and emerging environmental chemicals and have importance in the regulation of discharges, and thus is of very wide interest to the government regulatory bodies, environment protection groups, industry and the wider public in Europe. The project will bring Dr Liscio to work with Dr Hill, and allow her to benefit from a number of scientific and complementary training activities which will prepare the fellow for an independent research career in environmental science.

Keywords: analytical chemistry,endocrine disrupting compounds (edcs),antiandrogens,passive sampling,yeast recombinant screen,lc-ms-ms
Development of Virtual Screening Algorithms: Exploring Multiple Ligand Binding Modes Using Spherical Harmonic Consensus Clustering (DOVSA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-07-19
End date: 2012-07-18
Duration (months): 24.0
Total project cost (EUR): 166462.4
EU funding (EUR): 166462.4
Participants: 1
Project status: CLOSED

This project will advance the state of the art in virtual drug screening by developing novel spherical harmonic-based consensus clustering algorithms. The main disease that will be targeted in this project is the acquired immune deficiency syndrome (AIDS), caused by the human immuno-deficiency virus (HIV). However, the approach will be quite generic and will be broadly applicable to many other diseases. The approach will be tested and validated using 40 well-known drug targets from the DUD dataset. It will then be used to screen the French Chimiothèque Nationale library of some 36000 compounds for novel ligands which will bind the CCR5 co-receptor and hence block HIV infection. A small list of candidate entry-blocking compounds will be sent to Barcelona for experimental testing. By extending the SH-based consensus clustering technique, this project will provide a generic tool to help deal with cases where multiple ligands may be associated with multiple pocket sub-sites or which may bind multiple targets, and it will help to find new HIV entry-blocking compounds.

Keywords: computational chemistry,chemoinformatics,virtual drug screening,protein-ligand docking,hiv,ccr5,spherical harmonics.
Orbital Free Density Functional Theory: insights from quantum chemistry and atomic physics. (OF-DFT/MCHF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-10-01
End date: 2012-10-31
Duration (months): 25.0
Total project cost (EUR): 172903.2
EU funding (EUR): 172903.2
Participants: 1
Project status: CLOSED

This proposal aims to put me at the forefront of research in two related domains: quantum chemistry and atomic physics. These domains have the same origin in finding solutions to the Schrödinger equation. Although the methods in both domains stem from the same ab initio approach, they departed from their common ground and developed methods specific to their problems. A few decades ago a revolutionary method came to quantum chemistry: Density Functional Theory (DFT). In this theory the electronic density function replaces the traditional, more complicated wave function to describe the electronic structure of molecules. The implications for computational chemistry have been astounding. The successful development of density functionals to evaluate a system&apos;s energy, has made DFT a powerful tool, with applications from bio-chemistry to chemical reactivity. It has become the most popular quantum chemical tool. Today&apos;s calculations typically use the Kohn-Sham method which implies the introduction of orbitals, departing from the original spirit of the density-only theory. Motivated by their computational attractiveness (linear scaling, no orthonormalization,no Brillouin zone sampling) researchers have taken up the challenge to design orbital free functionals. This project aims towards the construction and evaluation of such orbital free functionals. Since DFT approaches, remarkably, never found their way to atomic physics, where their potential is evident and since ab initio methods from atomic physics still provide the highest quality density functions (corresponding to an eigenstate), the objectives in this project propose a synergy of concepts, methods and fundamental aspects in both fields. For the successful execution of this interdisciplinary proposal, milestones have been identified which, with the appropriate training, based on the experience and knowledge on functional development of Professor Tozer, is expected to lead to high quality publications.

Keywords: quantum chemistry,atomic physics,computational physics,computational chemistry,chemical physics
Theory and methods for evidence based perinatal health care and policy in cross-national studies (PERINATAL HEALTHCARE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2010-04-01
End date: 2012-09-30
Duration (months): 30.0
Total project cost (EUR): 269905.9
EU funding (EUR): 269905.9
Participants: 1
Project status: CLOSED

Improving the organisation of healthcare services is one way to contribute to better maternal and infant health. Over the past 10 years, my research at the Epidemiological Research Unit on Perinatal Health and Mother’s and Children’s Health, INSERM U953, has focused on assessing the impact of the organisation of care on the health of babies born very preterm (<32 weeks of gestational age) in France and other European countries and on the effects of the restructuring of obstetric and paediatric health services on access to care for pregnant women and newborns My aim for this fellowship is to strengthen my research capacities by integrating knowledge from the field of health services research. This fellowship with the Department of Health Evidence and Policy at Mount Sinai Medical Center in New York City, co-chaired by my outgoing fellowship supervisor, Professor Annetine Gelijns, offers me the opportunity to work in close collaboration with scientists who have expertise in evidence-based evaluation of health care and policy. My specific objectives are to (1) acquire knowledge about theory and methods in health services research (2) develop methods for the study of the comparative organisation of perinatal care (3) understand the organisation of health services research in the United States (4) develop a network of contacts with health services researchers. Expected outputs are two scientific publications, a validated protocol for the study of organisation of care and policy characteristics in neonatal and obstetrics units and materials for a workshop on health services research and a course at the doctoral level to be offered on my return to France. In the return phase, I plan to work actively with my research unit as well as other research units within the new Institute of Public Health at INSERM, directed by my scientific supervisor, Professor Gérard Bréart, to develop research that would apply methods from both epidemiology and health services research.

Keywords: health sciences,perinatal epidemiology,health services research,organisation of health care,maternal child health,neonatal intensive care
Creating conditions for persistence of biodiversity in the face of climate change (ECOCHANGE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-01-10
End date: 2013-01-09
Duration (months): 24.0
Total project cost (EUR): 173403.2
EU funding (EUR): 173403.2
Participants: 1
Project status: CLOSED

Recent models have been developed predicting climate change-induced habitat losses and extinction of many plants and animals. Their coarse scale may have over-estimated extinction threats due to their inability to capture small-scale habitat heterogeneity. Plus, they are difficult to validate. Proposed validations use current data as calibration and past data as verification. The Quaternary fossil record is thus essential to understand the mechanisms that have allowed past species persistence, and to improve our forecasting ability regarding their future performance. But data on species past distribution and dynamics has too been affected by coarse-scale issues. For example, evidence for woody taxa populations north of the classical pollen-based southern refugia during the last glacial maximum (LGM) has recently come from DNA and macrofossil studies. LGM refugia existed as habitat islands in a matrix of unsuitable landscapes, from which populations expanded in the Holocene. Such small populations – cryptic refugia – are indistinguishable in the pollen record and coarse-scale bioclimatic envelope models don’t detect them. Persistence of many species in future climates may, as it has in the past, depend on the preservation of cryptic refugia, and defining their physical environment is of great importance. However, cryptic refugia have been described in general terms. This study aims at defining the physical characteristics – topographical and geomorphological – of cryptic refugia for 3 Northern Eurasian tree taxa and integrate the resulting relevant physical parameters to local species-envelope models to improve our understanding of the role of cryptic refugia on species persistence during past climate changes, and so to better forecast biotic response to future climate changes. The study will use remote sensing data and a new continental plant macrofossil dataset that offers the opportunity to independently validate hindcast results from the species-envelope models.

Keywords: biogeography,palaeobotany,topography,bioclimatology,boreal forests (climate change),climate modelling (climate change),geomorphology,land use management (climate change)
A View from Heaven. Exploring the Potential of Remote Sensing Techniques to Study Spatial Patterns of Monastic Habitation on the East Bank of the Nile in Middle Egypt. (VIEWFROMHEAVEN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-09-15
End date: 2013-08-14
Duration (months): 35.0
Total project cost (EUR): 220500.0
EU funding (EUR): 220500.0
Participants: 1
Project status: CLOSED

Early Egyptian monasticism played a defining role in the establishment of monastic life in Europe. However, our understanding of the history of the formation and organization of monastic life in Egypt itself is incomplete. Whereas monastic centres in northern and southern Egypt are being extensively studied, the important region of Middle Egypt has scarcely received scholarly attention. From AD 300-800, this area had a thriving Christian life and a large number of monastic settlements. On the east bank of the Nile, monks settled mainly in Pharaonic tombs and quarries in the chain of hills hugging the river. They adapted the spaces to their needs and established communities. Most of these dwellings are still relatively intact. Since written documentation is scarce, this archaeological material presents a unique opportunity to complete our picture of the formation and organization of early Egyptian monasticism. A comprehensive study is necessary to understand how and when this monastic landscape took shape. Why did it assume its specific spatial pattern and how did it function, locally and in a wider sense? To answer this composite question, I intend to acquire skills in the interpretation of satellite imagery for the localization of sites and Geographic Information Systems (GIS) for integrated spatial data processing. An innovative interdisciplinary approach is essential to establish the intra- and intersite patterns of these monastic habitations. In conjunction with historical research and field survey, a view from heaven through satellite remote sensing (RS) will draw a map of the monastic landscape as a starting point for innovative site location modelling analyses using GIS techniques. Known historical data will be projected upon this new contextual backcloth to generate a new understanding of the development of monasticism in Egypt.

Keywords: spatial archaeology,satellite remote sensing,late antique egypt,early monasticism
BIOMETRICS AT A DISTANCE (BIO-DISTANCE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-07-01
End date: 2013-06-30
Duration (months): 24.0
Total project cost (EUR): 173469.4
EU funding (EUR): 173469.4
Participants: 1
Project status: CLOSED

Despite the practical importance and the advantages of biometric solutions to the task of verifying personal identity, their adoption has proved to be slower that predicted. The current market pull, mainly driven by the introduction of governmental applications, is still in its early stage. While technological aspects will still play an important role, demands for more consumer convenience will drive innovation in biometrics, with user-centered research actions focused on its transparent use, facilitating the ease of interaction with the system. Biometrics “on the move” is a hottest research topic aimed to acquire biometric data “at a distance” as a person walks by detection equipment. This drastically reduces the need of user’s cooperation, achieving low intrusiveness and thus, high acceptance and transparency. Its applications are very diverse, enhancing the customer experience where large number of people moves through a bottleneck (security checkpoints in airports, access control). It will also make a vast amount of surveillance cameras in non-cooperative or uncontrolled environments suitable for recognition purposes (e.g. placed in hallways or outdoors). The main objective of this proposal is to investigate a number of activities aimed to make biometric technologies applicable to data acquired at a distance and on the move. We propose the use of face and iris as the reference modalities, being the two traits that are attracting more efforts thanks to the possibility of their simultaneous acquisition. This aim is an important technological challenge, since the major limitation of current face and iris commercial systems is the degree of control and cooperation required during the acquisition. This project is an integrated approach that covers the whole structure of a biometric system, including basic research and algorithm development for the different stages of the system, as well as practical results through case studies implementation and evaluation.

Keywords: electrical engineering,security systems,biometrics,signal processing,image processing,computer vision,pattern recognition