Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Vortex enhanced liquid chromatography for HbA1c monitoring based diabetes management in a globalized setting (VortexLC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Belgium,Greece,Austria,France
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-03-01
End date: 2026-02-28
Duration (months): 48.0
Total project cost (EUR): 3014375.75
EU funding (EUR): 3014375.5
Participants: 4
Project status: SIGNED

Diabetes is one of the main health risks today with near pandemic dimension, causing blindness, kidney failures, stroke, heart attack, giving rise to very high health care costs (25% in the US) and reducing the quality of life of around 500 million people worldwide. The level of hemoglobin A1c (HbA1c) is used to assess long-term glycemic control and is the best predictor for the risk of developing chronic complication of diabetes and appropriate follow up of the patients. The golden standard is an expert laboratory HPLC method focusing on HbA1c quantification, which has limitations when other relevant hemoglobin variants are to be detected. For approximately 7 % of the world’s population which are carriers of such hemoglobin variants current methods lead to under-, over- or non-estimation of the HbA1c fraction. VortexLC will not only improve the quality of the analysis to give an instant full picture of the health status of diabetes patients, it will also produce a cheap point of care device. The use of vortex flows renders the approach compatible with mass manufacturing of plastic pillar array columns, that are not only much cheaper than commonly used packed bed columns, but wherein also higher separation performances can be obtained. The polymer columns will be fabricated using UV-nanoimprint lithography, plasma technology to make them porous and add a chromatographic coating, and lamination to close the column, all processes that can be scaled to roll-to-roll industrial manufacturing. The columns will be embedded in an instrument that allows for integrated sample preparation and miniaturized UV absorption and SERS detection, allowing for both quantification and identification of analytes. In the project a low footprint demonstrator of the novel system and columns will be built and tested with first synthetic, next human blood samples to quantify Hb1Ac and its genetic variants.

Keywords: microfluidics vortex nanoimprinting plasma porous coating chromatography hplc diabetes hb1ac
ROBUST Crisis Governance in Turbulent Times – Mindset, Evidence, Strategies (ROBUST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Denmark,Estonia,Italy,Belgium,Netherlands,Norway,Spain,Hungary,Czechia
Call: Politics and governance in a post-pandemic world (HORIZON-CL2-2021-DEMOCRACY-01, 2021)
Start date: 2022-10-01
End date: 2026-03-31
Duration (months): 42.0
Total project cost (EUR): 2995026.25
EU funding (EUR): 2995026.25
Participants: 10
Project status: SIGNED

The focus of European post-pandemic politics is currently on enhancing system capacities for ‘bouncing back’ from crisis to normalcy. These efforts draw on resilience research, which has become the dominant paradigm in crisis management. However, there are broad governance challenges that the resilience approach fails to consider. Centrally, how can European societies harness flexible adaptation and proactive innovation to deliver effective crisis responses in situations, where going back to the way things were is neither possible nor desirable? And how can democratic institutions uphold core values such as democracy, the rule of law, and fundamental rights in the face of crisis-induced turbulence? To address these challenges, the ROBUST project aims to set in motion a paradigm shift from ‘resilience’ (‘bouncing back’) to ‘robustness’ (‘building back better’) as the central principle of future crisis governance. The project breaks new ground by operationalizing the concept of robust crisis governance and investigating such responses empirically. We combine historical and comparative analysis at EU, national and local levels to gather a multi-dimensional data set out of which we identify the configurations of factors that drive (or block) robustness in crisis governance. The project studies responses by EU institutions and eight European countries to three recent crises (the financial, refugee and COVID-19 crises) to understand general patterns in system-level crises response, while we also conduct in-depth studies of localized COVID-19 responses ‘on the streets’ of 16 European localities to understand how EU, national and local crisis responses interact and are experienced by citizens. On this basis, the project delivers the elements of a new mindset along with policy recommendations for enabling the robust crisis governance of the future, all anchored in a learning hub that will serve as the social engine of the paradigm shift envisioned by the project.

Keywords: crisis governance robust governance multi level governance hybrid democracy societal intelligence network governance
Harnessing snap-through transition waves in multistable metamaterials for fluid-transport applications (SnaPump)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 2
Project status: SIGNED

In the last decade, flexible mechanical metamaterials have demonstrated their great scientific potential. By exploiting mechanical instabilities in such structures, researchers have observed the propagation of transition waves yielding both fundamental implications (analog material to understand ferroelectric phase transitions, dislocation motion in crystals) and engineering applications (elective signal transmission, acoustic insulators). Most studies focus on the properties of the waves at the metamaterial level, without analyzing the details of the transition at the building block level. As a result, the mechanisms that govern the propagation of these waves remain poorly understood, which greatly limits their range of application. In this research project I propose a bottom-up approach to investigate this class of phenomena. Specifically, I will experimentally and numerically study the overlooked mechanisms of the snap-through instability of a single bistable arch. This will allow me to design a 1D array of such arches connected via rotating hinges in which an elastic snap-through wave can propagate. I will then put to test this new knowledge in the rarely explored domain of fluid-structure interaction with mechanical metamaterials. Specifically, I propose to exploit these elastic waves for fluid transport applications via peristaltic pumping. This project will yield general rules to design structures that propagate controlled transition waves, and will open new avenues for their use in interaction with fluids.

Keywords: elastic instability,fluid structure interactions,non linear waves
Artificial Intelligence for Institutionalised, Multimodal, Gamified, Mass Democratic Deliberations (AI4Deliberation)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Greece,Netherlands,Italy,Switzerland,Germany,Ireland,United Kingdom,Slovenia
Call: Digital democracy (HORIZON-CL2-2024-DEMOCRACY-01, 2024)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 2999500.0
EU funding (EUR): 2999500.0
Participants: 13
Project status: SIGNED

Democracy is facing challenges including loss of trust in EU institutions, disillusionment and declining interest among citizens, increasing political polarisation, online disinformation and politically manipulated information, and a growing distance between citizens and elected representatives. We believe this can change if proper deliberative processes and tools are institutionalised that exploit the rapid advances in Artificial Intelligence and citizens’ post-Covid competences. We envision the next generation of digital deliberations as: grounded on solid democracy theory, multimodal (video, audio, text), usable and accessible, gamified (e.g. using skill points, scoreboards, missions, and avatars), mass, enabled by novel but also legal and ethical AI features (e.g., summarisation, moderation, fact checking, hate speech and toxicity detection) and easily adopted and institutionalized. In this context, the aim of AI4Deliberation project is to provide robust, ethical AI tools and comprehensive guidance to assist governments in institutionalising, using and evaluating multimodal, gamified, mass deliberations. The vision of the project is to equip governments with a theoretically solid and empirically tested set of AI-enabled deliberative processes, a comprehensive framework with practical guidelines, and an AI toolkit that will enable them to design, institutionalise, operate and evaluate transparent, ethical, inclusive, multimodal, gamified, mass citizens deliberations resulting in more active and inclusive citizenship and increased trust to rule-of-law based institutions by citizens. To achieve these ambitious objectives, the consortium brings together a team of world leaders in deliberative democracy, AI and LLMs (incl. vid-LLMs), argumentation mining, law and ethics, deliberation platforms (including video-based) while four large scale pilots will be conducted from city level to international discussing topics that include climate change and long Covid.

Keywords: artificial intelligence deliberative processes vid llms deliberation platform
Advancing Transcatheter Mitral Valve Repair (The Angelvalve Project AVVie)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Austria
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-02-01
End date: 2025-01-31
Duration (months): 24.0
Total project cost (EUR): 8748750.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

The Mitral butterfly implant is a posterior leaflet augmentation device which functions to prevent excessive posterior leaflet motion. The implant comprises a)a Nitinol frame designed to sit comfortably within the anatomy of the heart and to provide the overall structure of the implant,b)an artificial leaflet, in the form of a flexible mesh which serves to restrict the prolapsing leaflet and provide a surface for adequate coaptation, and c)a method of anchoring. The implant can be folded into a catheter to facilitate delivery and be deployed in the target region with minimal actuation. The shape memory capabilities of nitinol allow the implant to self-expand when released, and the design of the frame ensures the correct orientation within the valve, consequently, the procedure involves minimal actuated steps with the main mechanical complexity arising from the anchorage. The anchorage itself is achieved with a secondary self-expanding nitinol mechanism.
Beyond the breadline: Charitable food provision and survival strategies of the urban poor in a comparative perspective (FOOD CHARITIES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499144.0
EU funding (EUR): 1499144.0
Participants: 1
Project status: SIGNED

Food charities have become essential pillars in assisting the urban poor, offering a crucial buffer between food insecurity and hunger. Their significance, particularly after the Great Recession, is underscored by two pivotal shifts: one towards the sustainable utilisation of food surplus and waste reduction, and the other reflecting societal changes with diminishing welfare benefit provision. While considerable research addresses food insecurity and support, the literature lacks a robust framework to understand and compare Charitable Food Provision (CFP) across countries and cities. Despite the almost universal occurrence of such transitions, existing studies have not yet contextualised this phenomenon within the diverse arrangements of welfare and civil society regimes, and the influence of transitions in agri-food sustainability on CFP. Accordingly, this proposal aims to: 1. Use event sequence analysis to chart the historical trajectory of CFP in Italy, Japan, and the Netherlands, examining the emergence and consolidation of professionalised CFP sectors in diverse institutional settings. 2. Adopt mixed-methods social network analysis to examine current CFP dynamics in Palermo, Kyoto, and Rotterdam, focusing on providers interrelationships, operational modes, and their ties with both state and non-state authorities. 3. Harness urban ethnography to investigate the interdependence between food insecurity and support to understand how CFP becomes part of poor people’s survival strategies. Additionally, it introduces an innovative tool, tailored for city workshops, to facilitate real-time data collection on (CFP) urban dynamics. Hence, it combines the findings obtained by crafting an overarching framework to extend CFP comparison to other countries and cities. The research will create new knowledge across urban, sustainability, organisation, food, and social policy studies, offering an innovative, comparative insight into food support and insecurity.

Keywords: ethnography field theory food insecurity food support mixed methods social network analysis urban poverty
Selective induction of PYROptosis in acute myeloid leukemia cells with VECTORized DPP9 inhibitors (PyroVector)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: SIGNED

DPP9 (dipeptidyl peptidase 9) is a cytosolic serine protease. It recognizes and cleaves N-terminal dipeptides containing proline at the penultimate position. The enzyme is currently receiving strong international attention after it was reported that DPP9 inhibition induces inflammatory cell death (pyroptosis) in Acute Myeloid Leukemia (AML) cells. Pyroptosis is a lytic form of cell death that also causes a pronounced, local upregulation of the innate immune system. This is of particular interest to leukemia treatment because the immune response to leukemic cells is strongly suppressed. Very recently, however, reports have been published that identify other, non-cancerous cell types that also undergo pyroptosis upon DPP9 inhibition. This raises questions on how selective and safe DPP9 inhibition can be as a therapeutic strategy in AML. The host reported the first selective, nanomolar DPP9 inhibitors in 2023 and also discovered the first DPP9-degrading PROTACs (unpublished data). PyroVector’s mission is to selectively unleash these molecules’ pyroptosis induction potential against AML cells, by delivering them towards these cells with vector approaches. Given the general lack of knowledge on how to optimally target small molecules to AML cells, three molecules that recognize AML cells will be compared as vectors for DPP9 inhibitors: a monoclonal antibody, an AML cell-penetrating peptide, and a sialic acid analog. DPP9 inhibitors that are covalently linked to these 3 ligands, will be investigated in terms of internalization and pyroptosis induction in cells. Furthermore, AML selectivity and therapeutic potential in vivo will be characterized with the ultimate aim of validating the approach as a safe and effective therapeutic strategy for AML. Overall we are strongly convinced that this project can be an essential step toward a patient-friendly application of DPP9 inhibition or degradation in AML.

Keywords: dpp9,serine proteases,pyroptosis,adcs,drug delivery
Liquid Dosimetry via Electron Paramagnetic Resonance Spectroscopy (LIQUIDITY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-06-01
End date: 2025-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The problem: Lack of water-equivalent dosimeters for radiotherapy Cancer is a global public health problem. Radiotherapy is generally used as an essential method of cancer treatment. Measuring the absorbed dose of radiation to ensure that the radiation delivered to the patient is accurate, is paramount and critical to patient safety, since tumor control and side-effects are highly sensitive to the applied dose. For this purpose, in-vivo dosimetry (IVD) can be performed as a patient-specific measure of quality control and safety during radiotherapy. Clinical experience and dose prescriptions in radiotherapy have historically been based on the absorbed dose to water. However, when a calibrated dosimeter as for today, which is not water equivalent, is used under non-reference conditions, direct determination of the correct absorbed dose to water is not possible and many detectors show an over-response. Water equivalent dosimeters are not available but particularly desirable in clinical applications. The solution: A small, water-equivalent, non-toxic and liquid dosimeter with electron paramagnetic resonance spectroscopy readout This idea presents an innovative strategy for dose determination using a novel type of liquid, water-equivalent and non-toxic dosimeter with readout via electron paramagnetic resonance (EPR) spectroscopy. This novel liquid EPR dosimeter consists of a small (mm-dimensions) capsuled water-based liquid detector material that can be placed on the patient's skin or in body cavities to measure the delivered dose at relevant locations in clinical situations. The principle presented here is based on a dose-dependent EPR signal loss: Stable paramagnetic species dissolved in aqueous solution are transformed into diamagnetic products upon irradiation. The proposed solution is not an incremental improvement of an existing procedure but an innovative approach making IVD easier to use, cheaper, more accurate – and: water equivalent.
Multiple routes to memory for a second language: Individual and situational factors (MultiMemoryL2)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Learning a second language (L2) after early childhood is a challenge, and learners differ not only in how well they rise to this challenge, but presumably also in how they do it. For instance, a small minority of talented individuals is able to acquire a near-native accent in L2, despite the fact that the phonetic repertoire normally becomes dedicated to the native language within the first years of life. It seems thus plausible to assume that these learners have access to a different manner of phonetic learning. Different learning situations, e.g. learning a language in the classroom versus learning it by immersion, also seem likely to involve different acquisition mechanisms. However, we know almost nothing about such qualitative processing differences in L2 learning. Memory research, on the other hand, offers a number of dual-route or dual-system accounts that do describe different ways in which our brain stores and remembers information. The general dimension on which such routes differ is abstraction: New information may either be retained literally, or it could be abstracted to its most important features. The current project aims to use such theories and methods from memory research to investigate the hypotheses that there are several alternative routes to L2 learning, and that individuals, as well as situations, differ with respect to which of these routes is preferably taken. Both word / pronunciation and grammar learning will be examined, assessing in how far language domains differ concerning the variability of learning routes. Furthermore, the stage of L2 acquisition may play an important role. Hence, both the learning of an entirely new language and the processing of an already established second language (English) are included. Since the research fields of second language acquisition (how we learn a new language) and of memory (how we learn something in general) have so far taken entirely different paths, the project will be the first of its kind.

Keywords: individual differences situational differences l2 pronunciation talent episodic memory semantic memory complementary learning systems l2 word learning l2 grammar learning syntactic rule learning