Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Spatiotemporal organisation of bacterial outer membrane proteins (OMPorg)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 2235815.0
EU funding (EUR): 2235815.0
Participants: 1
Project status: SIGNED

The outer membrane (OM) of Gram-negative bacteria protects against environmental insult and is central to pathogenesis hence finding ways to disrupt its integrity is a route towards new antibiotics. However, our understanding of OM biology is limited. In particular, how the OM is organised is largely unknown. My laboratory recently discovered spatiotemporal Outer Membrane Protein organisation (OMPorg) in Escherichia coli, a new organising principle that explains how OMPs are turned over. We found that OMPs cluster into islands that can be mimicked in supported bilayers using purified proteins. As cells grow, OMP islands are displaced to the poles by new islands, leading to binary partitioning of old OMPs in repository cells following septation. Another poorly understood aspect of OM biology is how protein bridges that connect the OM to the inner membrane (IM) mediate functions across the periplasm. We have discovered that the characteristic immobility of OMPs in vivo, caused by OMP clustering, becomes imposed on IM proteins (IMPs) when OMPs and IMPs become connected by protein bridges. These exciting new findings underpin OMPorg. I will focus on two species, E. coli and P. aeruginosa, and exploit the tools I have developed to ask four interrelated questions: 1. What is the molecular basis of OMP island formation? 2. Do OMPs influence IMP functionality via protein bridges? 3. Do repository cells endow bacterial populations with ‘OMP memory’? 4. Do OMP islands coordinate OM processes? I will address these questions through an interdisciplinary research programme incorporating protein chemistry and proteomics, ensemble and single molecule microscopy on live cells and in supported bilayers and molecular dynamics simulations. OMPorg will answer major outstanding questions concerning organisation in the bacterial OM and how this impacts the biology of the cell envelope, which will have ramifications for biomedicine and biotechnology.

Keywords: outer membrane protein,organization,bacteria
Communities Under Siege: Everyday Challenges in the Divided City of Jerusalem (Divided communities)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Israel
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 182509.2
EU funding (EUR): 182509.2
Participants: 1
Project status: CLOSED

Social (in)justice is a key issue in today’s cities, which are characterized by growing socio-economic inequalities. Divided cities—such as Jerusalem and Nicosia—experience further tensions in light of their unstable geopolitical condition. While divided cities have been studied from a number of angles, little is known of the daily challenges that divided communities experience at the neighbourhood scale. This research proposes to study divided communities in East Jerusalem to examine the pressures that they experience and to elucidate the strategies they employ to better off their lives. Situated in the realm of urban planning, the study focuses on four key issues: a) governance, b) local leadership), c) housing, and d) municipal services, infrastructure and public space. The project utilizes diverse methods including interviews, focus groups, on-site visits, and mental maps to study the dynamics of integration and exclusion in three Palestinian and Israeli-Palestinian East Jerusalem neighbourhoods. This project involves an Advisory Board composed of experts in the fields of urban studies and political science, providing scholarly expertise and access to the research area. The project will be disseminated through scholarly publications and conference presentations. Moreover, a public outreach programme has also been designed to communicate the findings to local communities, NGOs, and policy makers. In addition, local Palestinian students will be participate in research activities. The project will advance the training of the Fellow, enabling her to reach a position of independence through learning new methods, mentoring students, and leading the planning and execution of the project. Findings from the research would extend beyond the particular status of divided cities, contributing to a more inclusionary planning theorization and practice by applying lessons from the experience of marginalized communities in Jerusalem to marginalized communities elsewhere.

Keywords: divided cities,community mobilization,urban planning,social justice,jerusalem
enhancing Innovation and Key Account Management by sme2EU (I-KAM2EU)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Italy,Italy,Italy,Italy,Italy
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 210559.0
EU funding (EUR): 210559.0
Participants: 9
Project status: CLOSED

The proposal aims at improving the innovation management capacity of SMEs to enhance their growth, competitiveness and cross-border partnerships. I-KAM2EU is the proposal by SME2EU (the Enterprise Europe Network consortium for the three Italian regions Marche, Tuscany and Umbria) to provide in its area in 2017-2018 the two services: 1) Key Account Management (KAM) for SME Instrument beneficiaries 2) Enhancing SME’s Innovation Management Capacity (EIMC) for innovating SMEs, continuing the ongoing positive experience in the biennium 2015-2016. The KAM service is reserved to Horizon 2020 SME Instrument Phase 1 or Phase 2 beneficiaries located in the three Italian regions covered by the proposal. I-KAM2EU will provide 36 KAM services in 2017-2018. I-KAM2EU expects to delivery 36 KAM services in 2017-2018, but the exact number will be determined by the amount (less or greater than the estimate) of the beneficiaries in the three regions for 2017-2018. The consortium will active a pool of 9 people to assess the SME’s needs, to support the choice of a right coach and to moderating the coach-client relationship, ensuring that beneficiary receives the most appropriate support services which enhance the probability of a successful and sustainable exploitation of its innovation project. The EIMC service is targeted to SMEs with significant innovation activities and with concrete potential for international growth, about product, process, service or business model innovation. I-KAM2EU will provide 50 EIMC services in 2017-2018 to SMEs selected through a structured procedure. The consortium will active a pool of 9 people, able to use IMPR3rove (for most structured SMEs) and/or Innovation Health Check (for less structured SMEs) tools to assess the SME’s current status of the innovation management system, to make a gap analysis, to define an action plan, to monitor it and to check the improvements.

Keywords: assessment,improvement,sustainable growth,ts 16555,sme instrument,eimc,enterprise europe network
PERSONALIZED ENGINE FOR CANCER INTEGRATIVE STUDY AND EVALUATION (PrECISE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Austria,Switzerland,Hungary,France,United States
Call: Understanding disease: systems medicine (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 5695712.5
EU funding (EUR): 3090312.5
Participants: 10
Project status: CLOSED

Despite of their great promise, high-throughput technologies in cancer research have often failed to translate to major therapeutic advances in the clinic. One challenge has been tumour heterogeneity, where multiple competing subclones coexist within a single tumour. Genomic heterogeneity renders it difficult to identify all driving molecular alterations, and thus results in therapies that only target subsets of aggressive tumour cells. Another challenge lies in the integration of multiple types of molecular data into mathematical disease models that can make actionable clinical statements. We aim to develop predictive computational technology that can exploit molecular and clinical data to improve our understanding of disease mechanisms and to inform clinicians about optimized strategies for therapeutic intervention. We propose to focus on prostate cancer, a leading cause of cancer death amongst men in Europe, but also prone to over-treatment. Our approach combines the exploitation of genomic, transcriptomic, proteomic, and clinical data in primary and metastatic tumours, prospective cohorts of well characterized prostate cancer patients, drug screenings in cell lines, and the use of the Watson technology, a last generation cognitive computer developed at IBM. The translational objective of this study is to develop technology for identifying disease mechanisms and produce treatment recommendations for individual patients based on a therapeutic biomarker panel. The proposed software framework will be accessible through a graphical interface that will facilitate its dissemination and use by researchers, clinicians, and biomedical industries. The framework will provide intuitive tools to deposit, share, analyze, and visualize molecular and clinical data; as well as to infer prognosis, elucidate implicated mechanisms and recommend therapy accordingly. This software framework will serve as a proof of concept for future development by industrial partners in Europe.

Keywords: systems medicine,network biology,prostate cancer,cancer diagnostics
What drives human behavior regarding global coastal migration and adaptation in response to sea level rise and extreme flood events? (COASTMOVE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2026-06-30
Duration (months): 66.0
Total project cost (EUR): 2499608.75
EU funding (EUR): 2499608.75
Participants: 1
Project status: SIGNED

Future sea level rise (SLR), extreme flood events, and urbanization pressure will increase coastal flood risk, and in the absence of costly flood protection measures in numerous regions, millions of coastal residents will be forced to migrate to safer locations. This research addresses the significant challenge these trends pose to adaptation and migration policy: Which coastal areas will be protected, and in which regions will coastal migration become the inevitable adaptation option? To tackle this challenge, I propose focusing on the human adaptive and migration behavior of residents and other agents within one global framework by integrating (1) a global coastal flood risk model with (2) an agent-based model (ABM). Current global coastal risk assessment and migration methods do not address individuals’ dynamic decisions regarding SLR and extreme flood events, and instead assume their adaptive behavior remains constant. However, the drivers that motivate people to migrate and adapt vary over time and space, and to capture these drivers (3) empirical data will be collected across seven surveys to parametrize realistic ranges for the behavioral rules in the ABM. (4) Novel global databases on flood protection, demography and socio-economy will be developed to extrapolate behavioral rules from the cases to other coastal areas. (5) State-of-the-art big-data methods using Twitter, mobile phone and IRS tax-filing data will be used to calibrate and validate migration patterns simulated by the global framework. The framework offers several advantages: high resolution (1x1km2) global migration, adaptation, and risk projections (2020–2100); novel maps of future migration hotspots; an improved understanding of what drivers (environmental, socio-economic, demographic, etc.) and interactions between stakeholders influence adaptation and migration decisions; and groundbreaking big-data validation. The framework will be used to assess adaptation and migration policies.

Keywords: coastal flood risk,sea level rise,climate adaptation,socio hydrology,risk assessment,migration
Decoding ISGylation events in Macrophages (DIM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The protein interferon stimulated gene 15 (ISG15) is a highly conserved ubiquitin-like modifier important for innate immune responses in mammals. ISG15 is highly abundant in cell lysates and enriched on the phagosome of interferon-activated macrophages. In humans, lack of ISG15 leads to increased susceptibility to infection by mycobacterial pathogens that reside in the phagosome of macrophages. However, both ISGylation events and their role are poorly characterized. This is partly due to the lack of analytical tools for the identification of ISGylation sites in cells. Here, I propose to develop a proteomics strategy to enrich and identify ISG15 targets that will also allow characterizing the interplay of ISG15 with ubiquitin. I will apply this method to analyze how ISGylation changes in response to Salmonella infection in macrophages. In order to understand the mechanisms that lead to susceptibility to intracellular pathogens, I will further use these approaches to test how ISGylation affects phagosome biogenesis in macrophages. ISG15 substrates identified in my proteomics screens will be validated and further characterized using biochemical, cell biological and immunological tools. Altogether, this data will provide new functional insights how ISG15 regulates defense mechanisms against bacterial infections.

Keywords: isg15,isgylation,ubiquitin like modifiers,phagosome,macrophages,mycobacterium tuberculosis
Mixed Biotic and abiotic functionalysed electrodes for Plant Microbial Fuel Cells applications (HiBriCarbon)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-03
End date: 2020-09-02
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

Plant microbial fuel cells (PMFC) are promising electrochemical devices that can produce electricity generated by active microorganisms present in plant soil. The reactions at both anode and cathode of PMFCs can be catalysed by microbial biofilms capable of oxidising organic matter (anode) and catalysing oxygen reduction (ORR) (cathode) producing electrical power from renewable resources. However, PMFC power output to date remains low and often unpredictable due to the variability in activity achieved by the electrodes microbial biofilms. Their selection in both anode and cathode is a fundamental requirement to enhance catalytic activity and produce higher power densities. This proposal aims at developing a conceptually new approach towards PMFC catalysis though the introduction of novel nanocomposite carbon electrodes that will combine intrinsic and microbially-mediated catalytic activity. These functional materials will integrate moieties that promote bacterial recruitment to select suitable microbial consortia onto carbon based electrodes for both anodic and cathodic reactions. In the case of the cathode, the carbon material will be selected by using electrochemical methods ex situ (voltammetry) in simulated aqueous environment in the presence of fertilizers and soil to also display ORR catalytic activity. Anode and cathode topography will be investigated to identify nanostructures that promote biofilm colonisation and to control density and stability of active sites. The best electrode materials will be modified with carbohydrates and peptides that promote cell adhesion to only recruit electroactive bacterial consortia. This project combines my expertise in carbon synthesis and microbial fuel cell devices with expertise in biofilm control and carbon material characterization of the host laboratory. New training in characterization of electroactive biofilms will be provided by a secondment through a cross – European collaboration at University of Rennes1

Keywords: carbon surface chemistry,electroactive bacteria,surface functionalization,oxygen reduction reaction,wastewater treatment
DigitalHealthEurope: Support to a Digital Health and Care Innovation initiative in the context of Digital Single Market strategy (DigitalHealthEurope)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Coordination and support actions
Countries involved: Ireland,Italy,Germany,Spain,Germany,Belgium,Belgium,Slovenia,Sweden,France,Netherlands,Portugal
Call: Support to a Digital Health and Care Innovation initiative in the context of Digital Single Market strategy (H2020-SC1-DTH-2018-1, 2018)
Start date: 2019-01-01
End date: 2021-09-30
Duration (months): 33.0
Total project cost (EUR): 3999993.75
EU funding (EUR): 3999993.75
Participants: 19
Project status: CLOSED

DigitalHealthEurope will provide comprehensive, centralised support to the digital transformation of health and care (DTHC) priorities of the Digital Single Market. The partners bring a broad range of collective knowledge and expertise, originating from the longstanding leadership and engagement in the whole spectrum of activities, from interoperability and standards to health service innovation and from the technical to the policy level. The project will support large-scale deployment of digital solutions for person-centred integrated care by identifying, analysing, and facilitating the replication of highly impactful best practices, utilising the consortium’s exceptional expertise on knowledge management and impact assessment (EIP on AHA repository of innovative practices, MAFEIP), twinning schemes, and mobilisation of stakeholders. A marketplace will enable organisations to find suitable partnerships. At least 46 twinnings ranging from adaptation of impactful best practices to full adoption will be carried out. A funding advice service and capacity building framework will be provided to further stimulate deployment and scale up. Building on the unique composition of the consortium, the project will establish and manage 3 collaboration platforms to align all efforts of ongoing and future initiatives supporting the 3 DTHC priorities. The partners will utilise their vast network of more than 1,100 members representing national, regional, and EU-wide stakeholders. The collaborative work will lead to common strategic agendas and commitments for action that will boost innovation and progress in the respective topics. A Board of Associated Experts with proven high-level competence on all key fields will support the delivery of an actionable strategic vision and recommendations for EU policy beyond 2020.

Keywords: digital health and care,health data,personalised medicine,digital single market,person centred integrated care
Airborne Wind Energy System Modelling, Control and Optimisation (AWESCO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Ireland,Germany,Germany,Germany,Switzerland,Belgium,Sweden,United States,Netherlands,Netherlands,Netherlands
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 2990467.2
EU funding (EUR): 2990467.2
Participants: 18
Project status: CLOSED

The height of conventional wind turbines is limited by the enormous stresses on the structure. The idea of the Airborne Wind Energy (AWE) is to replace the most efficient part of a conventional wind turbine, the tip of the turbine blade, with a fast flying high efficiency kite, and to replace the rest of the structure by a tether which anchors the kite to the ground. Power is generated either by periodically pulling a ground based generator via a winch, or by small wind turbines mounted on the kite that exploit its fast cross wind motion. While the concept is highly promising, major academic and industrial research is still needed to achieve the performance required for industrial deployment. This can best be done by innovative junior researchers in a closely cooperating consortium of academic and industrial partners. The ITN AWESCO combines six interdisciplinary academic and four industrial network partners with seven associated partners, all selected on the basis of excellence and complementarity. All partners work already intensively on AWE systems, several with prototypes, and they are committed to create synergies via the cooperation in AWESCO. The main task is to train fourteen Early Stage Researchers (ESRs) in training-by-research and to create a closely connected new generation of leading European scientists that are ready to push the frontiers of airborne wind energy. AWESCO is the first major cooperation effort of the most important European actors in the field and will help Europe to gain a leading role in a possibly huge emerging renewable energy market, and to meet its ambitious CO2 targets. In addition, the AWESCO early stage researchers will be trained in cutting-edge simulation, design, sensing, and control technologies that are needed in many branches of engineering.

Keywords: airborne wind energy,wind energy,kite power,innovative renewables