Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Finding biomarkers of anti-microbial drug resistance via a systems biology analysis of fungal pathogen interactions with the human immune system (SYBARIS)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Germany,Italy,United Kingdom,Portugal,France,Spain,Spain
Call:  (FP7-HEALTH-2009-single-stage, 2009)
Start date: 2009-11-01
End date: 2013-04-30
Duration (months): 42.0
Total project cost (EUR): 5672482.4
EU funding (EUR): 4291161.4
Participants: 9
Project status: CLOSED

We propose a systems biology study of the specificity of response of the cell-mediated immune system to fungal microorganisms in order to investigate the genetic basis of susceptibility to fungal disease and elucidate molecular mechanisms of drug resistance in fungal pathogens. An integrative approach, combining high-throughput and traditional wet-lab work with computational and bioinformatics methods, will be applied to identify biomarkers of resistance to currently available treatments and to develop novel putative drug target genes and pathways in different fungi. We will use Saccharomyces cerevisiae, a normally non-pathogenic yeast model organism, Candida albicans and Aspergillus fumigatus, two major recognized fungal pathogens as well as other Aspergillus spp. known to be multi-drug resistant and difficult to treat. This project meets the criteria of the call, the strategic objective of which is “to confront the increasing emergence and spread of antimicrobial drug resistant pathogens in Europe” by addressing a well-defined class of infectious disease caused by fungal pathogens, with significant morbidity and mortality in a large segment of the population, and a high economic cost due to resistance. The anticipated results are highly relevant to society in terms of reducing the burden of mortality and suffering in immunosuppressed patients and in terms of reducing medical costs associated with treating opportunistic fungal infections. The potential economic upside for novel broad-spectrum anti-infectives is very large. The worldwide market for antifungals is currently estimated at $4 billion US annually. We tackle the issues of anti-microbial drug resistance head on via a multidisciplinary systems biology study combining bacterial genetics, clinical and pharmacological research in a systems biology approach, integrating traditional wet-lab methods with those of functional genomics, proteomics, metabolomics and bioinformatics.

Keywords: systems biology,immunopharmacology,antifungal resistance,gwas,functional genomics,pathway analysis
Genomic variations underlying common behavior diseases and cognition trait in human populations (ADAMS)

Framework: FP7 — Cooperation
Programme: Health
Destination: Other Actions across the Health Theme
Action type: Collaborative project
Countries involved: Germany,Switzerland,Netherlands,United Kingdom,Germany,Germany,Russian Federation
Call:  (FP7-HEALTH-2009-single-stage, 2009)
Start date: 2009-10-01
End date: 2012-09-30
Duration (months): 36.0
Total project cost (EUR): 5678333.6
EU funding (EUR): 3000000.0
Participants: 12
Project status: CLOSED

The subject of the proposal is the search and analysis of genomic variations underlying Alzheimer&apos;s disease (AD), alcoholism and schizophrenia – wide-spread diseases in human populations. Schizophrenia and alcoholism are common forms of behavior pathology and disability in adult life. AD is a most common form of dementia in human populations. Though the genomic variations presumably associated with AD, alcoholism and schizophrenia were described in preliminary studies for European populations, the significance of the putatively associated alleles, genetic background as well as the role of environmental factors is still poorly understood for them. Within the framework of this project we plan to extend the studies of genomic variations underlying these diseases by performing genome-wide association analysis in cohorts of patients and normal individuals from several ethnic populations of Europe and Russia.The genetic factors for cognition endophenotype will also be studied. Candidate regions, both newly found and reported previously for these diseases will be additionally analyzed by sequencing. Such large scale population studies combined with deep analysis of particular genes and genomic regions will allow us to reveal genetic reasons for susceptibility to these diseases. On the basis of this research we propose to contribute to development of a diagnostic instrument for the analysis of genetic risk factors for AD, alcoholism and schizophrenia. Comparison of several ethnic cohorts (different populations from Russia and Central/Western and Southern Europe) will also help to elucidate the influence of genetic background and environmental factors on the etiology of neuropsychiatric diseases. Consortium includes 6 groups from EU/AC and 7 groups from Russia. The participants are leading specialists in their fields and have joint publications on subjects related to this proposal.

Keywords: alzheimer's disease,alcoholism,memory,schizophrenia,association studies,candidate regions,snp
Preclinical study of Recombinant human Anti-C5 for the Treatment of atypical HUS (PRATH)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Italy,United Kingdom,France
Call:  (FP7-HEALTH-2009-single-stage, 2009)
Start date: 2010-05-01
End date: 2012-04-30
Duration (months): 24.0
Total project cost (EUR): 2528472.6
EU funding (EUR): 1804435.0
Participants: 4
Project status: CLOSED

The Complement System is implicated in the onset, maintenance and amplification of tissue damage in several inflammatory clinical conditions. Haemolytic uraemic syndrome (HUS) is a systemic disease characterized by damage to endothelial cells and erythrocytes, thrombocytopenia, micro thrombosis and kidney failure. During the last few years it has become evident that familial atypical HUS is strongly associated with mutations in proteins needed either for activation or regulation of the alternative pathway of Complement. For this reason, ADIENNE S.r.l. (Italy) has obtained orphan designation EU/3/08/571 for its Recombinant human minibody against Complement component C5 for the treatment of atypical Haemolytic Uraemic Syndrome (aHUS) associated with an inherited abnormality of the Complement system in September 2008. This molecule has been already characterized by in vitro and in vivo experiments and a complete preclinical study is the next step for the development of this potential orphan drug useful for the treatment of aHUS. Preclinical studies of this EU designated orphan medicinal product has been design by ADIENNE S.r.l. and will be perform in collaboration with the University of Trieste (which has isolated and characterized the recombinant human antibody against C5), the Imperial Collage of London, ADIENNE Spain SL and CIT-Safety and Health Research Laboratories. In this two years project we plan to perform pharmacological, pharmacokinetic and toxicological studies, a pre-clinical evaluation of the therapeutic efficacy of the anti-C5 antibody in mouse models of aHUS and characterization of GMP-grade anti-C5 antibody production. Data collected in this project will be sufficient for a complete “Preclinical development of substances with a clear potential as orphan drugs” as proposed in topic “Rare diseases - HEALTH-2009-2.4.4-2”.

Keywords: ahus complemnt system neutralizingrecombinat antibody
Resolution Enhanced Microscopy for Medical Diagnostics (REMEDI)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: Netherlands,Germany,United Kingdom,Germany
Call:  (FP7-HEALTH-2009-single-stage, 2009)
Start date: 2010-01-01
End date: 2013-06-30
Duration (months): 42.0
Total project cost (EUR): 2338267.2
EU funding (EUR): 1580100.0
Participants: 5
Project status: CLOSED

Since the histopathological diagnosis of tumours is based on microscopy, it would be highly desirable to possess a microscopical technique allowing morphological investigation with a wide zoom range, high resolution and the implementation of multiplex staining. Thus, the goal of the REMEDI project is to explore the possibilites of novel light microscopy techniques, which overcome the diffraction limit of visible light and extend the range of observation to the molecular level of proteins in tumour cells and analyze their interaction and spatial distribution. This proposal aims at the use of single-molecule-microscopy of cancer tissue samples with ultra-high sensitivity, simplified handling and increased speed of analysis. This shall be accomplished by the development of a novel resolution-enhanced microscopy platform with an integrated novel CMOS camera and an adequate image acquistion and analysis software. The REMEDI platform will be validated with two relevant applications: diagnostic/experimental pathology of breast cancer and alterations of plasma membrane components of lymphoma cells.

Keywords: ultra-resolution microscopy,single-molecule microscopy,palm/storm,cmos camera,medical diagnosis,pathology,tumour immunology
DEmonstration of COunterTErrorism System-of-Systems against CBRNE phase 1 (DECOTESSC1)

Framework: FP7 — Cooperation
Programme: Security
Destination: Increasing the Security of citizens
Action type: Coordination and support actions
Countries involved: Netherlands,Austria,France,Germany,Sweden,European organisations area,Finland,Spain,Austria
Call:  (FP7-SEC-2009-1, 2009)
Start date: 2010-04-01
End date: 2011-06-30
Duration (months): 15.0
Total project cost (EUR): 1587642.0
EU funding (EUR): 1001627.0
Participants: 9
Project status: CLOSED

DECOTESSC1 proposes a DEmonstration of COunterTErrorism System-of-Systems against CBRNE phase 1. A thorough understanding of the system-of-systems’ structure will be developed, the requirements for an ideal system will be proposed as well as a description of the current state-of-the art. A gap analysis will reveal the differences between the current situation and the ideal situation. The gaps thus obtained will be ranked. Also, in order to fill the gaps a strategic roadmap will be developed to guide the improvement cycle by proposing, technological and organizational topics to be addressed and implemented in a future phase 2 of the demonstration project CBRNE counterterrorism. This all will be primarily done by a Core Group of partners. In addition, to achieve all this, the DECOTESSC1 project will, on top of the efforts of the Core Group, consider the needs of the various stakeholders (government representatives, local authorities, users with different think-tanks, universities, RTO’s and industry (including SME’s)) by direct interaction. This will be achieved by involving the stakeholders, collected into an Expert Group, continuously by organizing workshops at relevant moments during the work of DECOTESSC1, by organizing a mid-term stakeholders meeting and well as a final symposium. Interviews with individual stakeholders will also be a mechanism for interaction. All interactions above will not only provide input for DECOTESSC1’s work but also provide dissemination of its findings throughout the EU community and raise awareness for this very important subject area in the mean time.

Keywords: cbrne,system,state-of-the-art,gap analysis,strategic roadmap,demonstration,dissemination
Planetary Entry Integrated Models (PHYS4ENTRY)

Framework: FP7 — Cooperation
Programme: Space
Destination: Strengthening the foundations of Space science and technology
Action type: Collaborative project
Countries involved: Italy,United Kingdom,Italy,France,France,Spain,Russian Federation,Belgium,Italy,Poland
Call:  (FP7-SPACE-2009-1, 2009)
Start date: 2010-05-01
End date: 2014-04-30
Duration (months): 48.0
Total project cost (EUR): 2791134.27
EU funding (EUR): 1961533.0
Participants: 13
Project status: CLOSED

One of the major technological challenges associated with the access to planetary surfaces is the entry of the space vehicle in the planetary atmospheres at superorbital speeds. The problem is the very large heat released to the vehicle surface by the surrounding gas either as convective heating or as radiation. Optimization of the thermal shield design can have a profound impact on the overall mission mass, volume (and therefore energy and cost) budgets. However, a poor knowledge of the physics of hypersonic entry is the limiting factor. Uncertainties increase with the entry speed, in particular as radiation becomes a considerable contribution to the overall heat load. Significant advance can only be achieved when the uncertainties in the physical modelling have been considerably reduced. The main goal of this study is, therefore, a thorough analysis of the physics behind space vehicle entry into planetary atmospheres and an improvement of crucial elements of the modelling that allows reliable predictions of flight conditions. This study is therefore concerned with the development of advanced chemico-physical and plasma models of hypersonic entry flows. Advanced models mean the description of the nonequilibrium chemical kinetics of the high temperature medium on the basis of a state-to-state approach. This approach, in turn, calls for a microscopic description of the elementary processes that play a role in the high temperature reactive gas mixtures surrounding the space vehicles during the entry phase. The predictive capabilities of the theoretical models will be assessed against well defined experimental measurements and their impact on the overall heat flux to the surface will be estimated by Computational Fluid Dynamics simulations of realistic ground and flight tests.

Keywords: planetary atmospheres,entry,nonequilibrium kinetic modelling,ground testing,molecular dynamics,cfd
Safety and Protection of built Infrastructure to Resist Integral Threats (SPIRIT)

Framework: FP7 — Cooperation
Programme: Security
Destination: Increasing the Security of infrastructures and utilities
Action type: Collaborative project
Countries involved: Netherlands,Germany,France,United Kingdom,Austria,European organisations area,Poland,United Kingdom,Switzerland,Germany,Netherlands
Call:  (FP7-SEC-2009-1, 2009)
Start date: 2010-08-01
End date: 2013-07-31
Duration (months): 36.0
Total project cost (EUR): 4884301.0
EU funding (EUR): 3497684.5
Participants: 11
Project status: CLOSED

Terrorist attacks by bombing or CBR-agents are threats with a low probability but with disastrous consequences. There is strong need to protect people, the societal community and critical infrastructures and utilities against being damaged, destroyed or disrupted by deliberate acts of terrorism. Solutions have to be derived to realize sufficient resilience of the urban infrastructure for rare occasions with minimum effect on normality. Hitherto, normal regulations and building guidelines do not take into account the CBRE threat. Fortunately, the required specialist knowledge is available on explosion dynamics, response of structures, dispersions of toxic agents and the injuries. This knowledge should be explored to derive the required solutions. Therefore, the SPIRIT Consortium was formed to bring the required expertise together, make these commonly available and to find solutions that can be integrated into normal life and planning and building procedures. Within SPIRIT a terrorist attack with the whole scope of CBRE-threat is addressed. The main outcome of the project is an integrated approach to counter CBRE-threats, including proposed guidelines for a EU Regulatory Framework. With this approach, government, end users of buildings and designers can define and achieve a desired level of protection. The SPIRIT contribution to built infrastructure protection will be: - A methodology to quantify the vulnerability of built infra in damage, number of injuries and loss of functionality and services; - A guidance tool to assess the vulnerability and define efficient and effective countermeasures to achieve a required protection level; - Draft guidelines to enable safety based engineering and the incorporation of CBRE protection; - A suite of ready to use CBRE countermeasure products. The overall goal of the SPIRIT project is to contribute to people safety and increase the resilience of built infrastructure against a terrorist attack.

Keywords: safety based design,vulnerability assessment,cbre-threat,built infrastructure
Road-mapping study of CBRNE demonstrator (CBRNEMAP)

Framework: FP7 — Cooperation
Programme: Security
Destination: Increasing the Security of citizens
Action type: Coordination and support actions
Countries involved: Sweden,United Kingdom,Czechia,Germany,France,Sweden,France,France,Germany,Sweden,Italy,Belgium
Call:  (FP7-SEC-2009-1, 2009)
Start date: 2010-06-01
End date: 2011-09-30
Duration (months): 16.0
Total project cost (EUR): 1662022.4
EU funding (EUR): 1376185.0
Participants: 14
Project status: CLOSED

The CBRNEmap will address the cross-cutting activity of the becoming CBRNE Demonstrator using a holistic approach, putting end-users, industrialists and other stake-holders together with members of the S&amp;T community in the front seat from the start of the activity. The CBRNEmap will evaluate the complex matrix of temporal events (before, under and after), against sectors (law enforcement, Civil protection – rescue and Health together with such processes as e.g. Boarder control, Mass Transport), taking in consideration that each of the letters CBRNE, may have its own aspects of vulnerabilities, priorities and possible solutions. These generic needs will be matched by advanced technological solutions integrated at the system of systems level to become the CBRNE Demonstrator. The CBRNE Demonstrator road-map for development of technologies and systems will take into consideration all present and past activities and search for generic solutions of technologies relevant to the full European setting at both the societal and individual level. Furthermore, it will consider all aspects prior to production (remaining development, IPR, market and more). The phase 2 project has eventually to produce a product, a prototype or a demonstrator of value to all EU 27. CBRNEmap will prioritise demonstration tasks based on systematic analysis of end-user requirement and comprehensive reviews of available CBRNE S&amp;T investments. The final roadmap will be developed for an optimised demonstration programme based on a Concept Development &amp; Experimentation (CD&amp;E) approach. Interlinked with developing the road map for the CBRNE demonstrator is the analysis of gaps and needs in CBRNE research. A stake holder signed suggestion for future research investments will be an important delivery of CBRNEmap.

Keywords: cbrne,demonstrator,generic needs,integrated solutions,system of systems,research,s&t,pan-european.
Versatile InfoRmation Toolkit for end-Users oriented Open Sources explOitation (VIRTUOSO)

Framework: FP7 — Cooperation
Programme: Security
Destination: Intelligent surveillance and enhancing border security
Action type: Collaborative project
Countries involved: France,France,Spain,Austria,Denmark,France,Netherlands,Netherlands,Switzerland,Italy,Czechia,United Kingdom,Ireland
Call:  (FP7-SEC-2009-1, 2009)
Start date: 2010-05-01
End date: 2013-06-30
Duration (months): 38.0
Total project cost (EUR): 11722835.13
EU funding (EUR): 7999182.55
Participants: 19
Project status: CLOSED

VIRTUOSO projects aims at providing European Security stakeholders with a toolkit based on an open-source-software framework and a set of advanced information processing tools. This toolkit will allow building end-user oriented applications: - Ranging from open source collection to decision support - Providing at each step actionable, rated, validated information - Integrated in an open framework in order to accept existing or future tools - Compliant with legal &amp; ethical issues The VIRTUOSO toolkit will increase user productivity by automating time consuming activities and eliminating current bottlenecks that will be accurately identified with a large panel of users. Due to numerous application domains and the various size of the resources needed by the application of such a toolkit, this toolkit will demonstrate high level scalability, from mobile to High Power Computing systems. Cooperation of various European agencies will be addressed by proposing a standard, open and Interoperable toolkit, facilitating storage and sharing of information. Guidelines will be proposed.

Keywords: open source information,open framework,open platform,data mining,decision support,end-user oriented
High Quality European GaN-Wafer on SiC Substrates for Space Applications (EUSIC)

Framework: FP7 — Cooperation
Programme: Space
Destination: Strengthening the foundations of Space science and technology
Action type: Collaborative project
Countries involved: France,Germany,Sweden,Germany,Germany
Call:  (FP7-SPACE-2009-1, 2009)
Start date: 2010-11-01
End date: 2013-10-31
Duration (months): 36.0
Total project cost (EUR): 3282694.02
EU funding (EUR): 1989426.0
Participants: 5
Project status: CLOSED

The project „ High Quality European GaN-Wafer on SiC Substrates for Space Applications” (EuSiC) is aiming at establishing an independent, purely European sustainable supply chain for Gallium Nitride (GaN) based space technologies. The project will significantly reduce the dependence on critical technologies and capabilities from outside Europe for future space applications. An independent supply chain has to include countries of the European Community (EC): a supplier of high-quality semi-insulating Silicon Carbide (SiC) substrates, qualified sources to perform GaN epitaxial layers and as well manufacturers with leading knowledge in GaN device technology required e.g. for Monolithic Microwave Integrated Circuits (MMIC’s). At present, the missing link in this chain is a reliable source for high-quality 3 inch semi-insulating SiC substrates in Europe. The intention of this project is to improve the quality of semi-insulating SiC-substrates at SiCrystal AG, the leading manufacturer of SiC substrates in Europe. The provided substrates shall be analyzed and evaluated by epi-growth specialists IAF, III-V-Lab, and QinetiQ. Finally devices shall be built and verified on the created GaN epi-wafers by UMS. Continuous monitoring and several feedback loops to the quality of the substrates will enable an accelerated development at SiCrystal AG. Also impacts to improvement of the performance of GaN devices are expected. The project will complement activities already undertaken by European Space Agency ESA, who has assembled a consortium of competent partners under the: GaN Reliability Enhancement and Technology Transfer Initiative (GREAT2).

Keywords: space technology,radar,microwave application,semi-insulating silicon carbide,gallium nitride technology