Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Covering mappings and their applications in functional equations, difference equations and optimization (COVMAPS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-06-11
End date: 2014-06-10
Duration (months): 24.0
Total project cost (EUR): 151426.8
EU funding (EUR): 151426.8
Participants: 1
Project status: CLOSED

There will be considered covering mappings and their applications. The properties of covering mappings in generalized metric spaces will be studied. Moreover, sufficient solvability conditions for inclusions defined by conditionally covering multi-valued mappings in metric spaces will be obtained. This results will be applied to the following problems. For difference equations there will be studied such issues as solvability, equilibrium existence and stability. In addition, there will be studied several types of functional equations. This part of research will be based on the result obtained for covering mappings in generalized metric spaces. Finally, there will be studied questions of global solvability for control systems and necessary optimality conditions for control systems defined by Volterra equations.

Keywords: covering mappings,generalized metric,functional equations,difference equations,control systems,optimal control theory
The role of Base Excision Repair (BER) for extreme radiation and desiccation resistance of Deinococcus radiodurans (BERINDR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-04-01
End date: 2014-03-31
Duration (months): 24.0
Total project cost (EUR): 208672.4
EU funding (EUR): 208672.4
Participants: 1
Project status: CLOSED

Deinococcus radiodurans (DEIRA) is an extreme radiation and desiccation resistant bacterium, which tolerates radiation doses up to 5000 Grays without loss of viability. The mechanism of this outstanding resistance is not known, but is probably a result of efficient genome packing, cell structure and DNA repair. For ten years the fellow has studied structure/function relations of proteins in the Base Excision Repair (BER) pathway from DEIRA, in order to determine their role for the extreme radiation resistance. Results from crystal structures of six BER proteins show that they possess both catalytic and structural modifications which may improve the DNA repair efficiency and repertoire of this organism. The general idea is that double strand break (DSB) repair is most important for the ability of DEIRA to maintain its genome stability during exposure to ionising radiation. However, recent results show that BER proteins are important for prevention of DSB, and suggest that the BER pathway is more important for the radiation resistance of DEIRA than previously believed. This hypothesis will be tested by performing gene expression profiling (RT-PCR) of native strains and analysis of genome reassembly and viability of BER knock out strains, upon exposure to ionising radiation. The biological function of metal clusters in selected BER proteins will also be analysed by Electron Paramagnetic Resonance (EPR) and X-ray crystallography. The project will be hosted by Instituto de Technologia Química e Biológica (ITQB) at the Universidade Nova de Lisboa, Portugal, and will benefit immensely from the infrastructure and multidisciplinary expertise offered by this institute. The project will facilitate training within gene expression profiling, genetics (generation of knock out strains) and advanced metallo-enzyme analysis (EPR), and thus extend the fellows current toolbox for protein function and structure analysis which will enable her to obtain professional maturity.

Keywords: natural sciences,biological sciences,biology,molecular biology,structural biology,radiobiology,molecular genetics
Understanding the evolutionary mechanisms of invasion success: Selective footprints in the genome of an Euro-invader – the raccoon dog (Nyctereutes procyonoides) (EUROINVADERS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-10-01
End date: 2014-09-30
Duration (months): 24.0
Total project cost (EUR): 201877.8
EU funding (EUR): 201877.8
Participants: 1
Project status: CLOSED

It is a worldwide, worrisome phenomenon that faunal endemism is threatened by introduced species populating new habitats, a process that is aided by the growing globalization which makes natural dispersal barriers more permeable. One of the most successful invaders of Europe is the raccoon dog (Nyctereutes procyonoides), a mammal that severely affects endemic biodiversity while thriving in new environments. The species’ peculiar evolutionary history was primarily facilitated by its ability to quickly adapt. While previous research has provided some knowledge of the ecological and environmental conditions the species has adapted to, we lack crucial understanding of the genetic mechanisms that render such a dramatic expansion possible. I propose a genetic study utilizing modern, next generation sequencing and DNA capture methods in order to investigate the underlying mechanisms that have facilitated adaptive processes in raccoon dogs. More specifically, by means of sequencing the complete transcriptomes I will determine candidate loci selection has acted upon, investigate population specific patterns of alternative splicing and lastly infer genes that are differentially expressed. In a second phase of the project I will employ targeted DNA capture on a population wide sampling of European raccoon dogs to assess allele frequency spectra of all candidate loci showing signatures of selection. In combination with additional neutral loci and the implementation of spatially explicit modeling I will develop an evolutionary model depicting how adaptive variants are spread and maintained in a changing environment. By synergizing novel molecular technologies with sophisticated modeling approaches the study pioneers the field of wildlife population genomics and will provide new, valuable insights into the biology of invasions. Moreover, the project’s scientific potential coupled with the competencies at the Turku University will help to further advance in my academic career.

Keywords: evolutionary biology,nature conservation,invasive species,raccoon dogs,selection,ecological genetics,population genetics,rnaseq,transcriptome,dna capture,demographic & spatially explicit modeling
Functional analysis of osmo-sensitive signalling processes regulating the metabolic response to environmental stress (CELL WALL METABOLISM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-03-01
End date: 2014-05-31
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

Plants use light energy, carbon dioxide, and water to produce monosaccharides - the building blocks of the polysaccharides forming plant cell walls. Plant cell walls represent the first line of defence against environmental stress while representing the bulk of the biomass used for bioenergy production. Their composition and structure influences both efficiency of bioenergy production and resistance of food crops to biotic / abiotic stress. The plant cell wall integrity maintenance mechanism monitors the functional integrity of the wall and initiates changes in cell wall structure / composition and metabolic changes in response to cell wall damage (CWD) to maintain functional integrity of the cell wall. The aim of the proposed research is to dissect the mode of action of the mechanism coordinating cell wall integrity maintenance with primary metabolism in Arabidopsis thaliana. Previous work in the host lab has implicated sugar-based signalling and turgor-sensitive processes in the response to CWD. The host lab has developed FRET-based nanosensors targeted to different cellular compartments for in vivo soluble sugar detection. These sensors will enable determination of the effects of CWD and turgor manipulation on intracellular soluble sugar distribution with subcellular resolution. In addition, a phospho-proteomics approach will be employed to identify and functionally characterise novel proteins required for mediating the response to CWD and turgor induced metabolic changes. Candidate proteins identified in the screen will be validated by biochemical assays and phenotypic characterisation of candidate gene knockouts. The results of this project will provide novel insights into the cell wall integrity maintenance mechanism that could lead to improved food crop performance and facilitated bioenergy production.

Keywords: plant cell wall,cell wall damage (cwd),cellulose biosynthesis inhibition (cbi),isoxaben,sugar,primary metabolism,fret-based nanosensors,turgor,phospho-proteomics
Global characterization of post-transcriptional regulatory interactions in DNA damage response (POSTSCRIBEDNADAMAGE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-07-01
End date: 2014-06-30
Duration (months): 24.0
Total project cost (EUR): 174475.2
EU funding (EUR): 174475.2
Participants: 1
Project status: CLOSED

The proposed project aims to identify the dynamics of RNA-protein interactions during DNA damage response (DDR) using high-throughput “omics” approaches. The mechanistic basis of DDR has been classically thought to consist of an "early" post-translational response, which results in activation of several signalling pathways and transciption factors. These activate the "late" transcriptional reprogramming influencing DNA repair, cell cycle regulation and apoptosis. However, for an immediate and effective response, global post-transcriptional control of mRNA stability, splicing and translation may be crucial during “immediate-to-early” DDR. In this project, I will employ biochemical, cell, systems biology and computational approaches to study the relevance of post-transcriptional regulators such as RNA-binding proteins and microRNAs in DDR. Quantitative proteomics will be applied to identify the differentially mRNA-bound proteins after the exposure of human cultured cells to ionizing radiation. Validation of protein candidates will be carried out by biochemical and deep sequencing approaches. In addition, I will characterize the transcriptome-wide response of existing RNA molecules as well as the newly synthesized transcripts. This will provide a global insight into the dynamics of RNAs and proteins during DDR. The proposed project explores a previously uncharacterized link between post-transcriptional RNA operons and DDR. The results and implementations of this project will significantly contribute to the understanding of the regulation of DDR, as well as have potential clinical and translational impact. Novel tumour-specific RNA-protein interacting partners may serve as candidates to selectively induce cell death in tumour cells. The proposed project will enable a focused career development period in the scope of European mobility for the researcher who will gain a high level of expertise in systems biology and establish several international collaborations.

Keywords: post-transcriptional regulation,dna damage response,high-througput approaches,rna-binding proteins,cell biology,genomics,proteomics,functional biology,computational biology,systems biology
Optical Probes for Membrane Potential via Photoinduced Electron Transfer (VOLTAGE-PROBE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-07-01
End date: 2014-06-30
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

This project is concerned with supramolecular chemistry and the molecular engineering of optical fluorescent probes for sensing the voltages across plasma membranes in excitable cells such as neurones. The project is a combination of molecular design, organic synthesis, physical organic chemistry, spectroscopy and photobiology. The idea is to establish a competition between fluorescence and photoinduced electron transfer; the relative rates of these two processes will be sensitive to the electric field, thus the brightness of the fluorescence will provide a map of the voltage. The project builds on three areas of expertise in Anderson’s group: (a) synthesis and photophysics of functional dyes; (b) molecular wires and (c) design and synthesis of probes for membrane potential in lipid bilayers based on second harmonic generation. Patrik Neuhaus has an exceptionally strong background in spectroscopy and physical organic chemistry. He also has the knowledge of organic synthesis to make rapid progress with this project. However he has no previous experience of investigating the behavior of compounds in lipid membranes. This project will provide him with high-level training in an important and topical field, while enabling him to broaden his horizons.

Keywords: physical sciences,chemistry,organic chemistry
Deterministic coupling between SITE-controlled, dilute nitride-based LighT Emitters and tailor-made photonic-crystal structures (SITELITE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-07-01
End date: 2014-06-30
Duration (months): 24.0
Total project cost (EUR): 193726.8
EU funding (EUR): 193726.8
Participants: 1
Project status: CLOSED

The establishment of a simple, reliable method for the deterministic coupling of nm-sized light emitters with photonic crystal (PhC) cavities is expected to propel the field of nanophotonics into a new era. Indeed, the possibility to place single quantum objects at arbitrary points of a PhC structure would allow for the realization of complex photonic circuits, integrating single- and entangled-photon sources as well as PhC routers, switches, and delay lines. The SITELiTE project will position itself at the forefront of this forthcoming revolution, through the exploitation of a novel method for the fabrication of site-controlled nano-emitters (quantum dots, but also individual impurity complexes) by spatially-selective hydrogenation of dilute-nitride materials, recently demonstrated by the Host Institution [the G29 laboratory of Sapienza University of Rome; see, e.g., Adv. Mater. 23, 2706 (2011)]. The PhC cavities employed by the present project will be designed with an innovative semi-analytic method, recently introduced by the fellow, Dr. M. Felici [Phys. Rev. B 82, 115118 (2010)]. Through the definition of a direct relationship between the target electromagnetic field distribution and the dielectric constant of the cavity supporting it, this method eliminates the need for the cumbersome, computationally demanding trial-and-error procedures that currently hinder further developments in the field of PhC cavity design. Initially, this approach will be applied to cavities supporting modes with Gaussian envelope function and ultra-low cavity losses. Then, the project will focus on the engineering of PhC structures with more complex mode distributions, including systems of coupled cavities and PhC cavities with disorder-insensitive properties. The designed PhC structures, integrated with the light emitters fabricated by spatially-selective hydrogenation, will be realized by electron-beam lithography, and characterized with advanced optical spectroscopy techniques.

Keywords: nanotechnology,photonics,nanophotonics,site-controlled quantum dots,defect engineering,design of photonic crystal microcavities,dilute nitrides,hydrogen in semiconductors
Health consequences of the alcohol hangover (HANGOVER (KEELE))

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-08-01
End date: 2014-07-31
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

Need for the research Little is known about next day, so called alcohol hangover effects. However, assembling and disseminating evidence on alcohol hangover effects falls under priorities 5.4 and 5.5 of the European Commission Strategy on Alcohol. The proposed research into the cognitive consequences of alcohol hangover and the relationship between hangover symptoms and risk for alcoholism will fill significant gaps in the existing knowledge base. Host and researcher The host, Dr Richard Stephens (Keele University), is a prominent psychobiology researcher and one of the world’s leading alcohol hangover researchers. The planned research will enable Dr Stephens’ lab to continue to grow, expanding its members skills and widening its network of collaborators. The candidate research fellow, Dr Lauren Owen (Swinburne University of Technology), is one of Australia’s most-published young researchers. Dr Owen will transfer knowledge and expertise in computerised neurocognitive assessment into Europe, while herself gaining new skills and developing a wide network of contacts in the area of alcohol / alcohol hangover. Multidisciplinary nature A multidisciplinary project is proposed bringing together researchers with expertise in psychobiology, neurocognitive assessment, cognitive science and analytical chemistry. The research aims to gather and disseminate reliable data on the behavioural and dependence consequences of alcohol hangover. Benefits to Europe Benefits are transfer of knowledge into Europe pertaining to state of the art computerised neurocognitive assessment and providing deliverables essential to the continued success of European-based research on alcohol / alcohol hangover. The European Research Area will be promoted by (i) the planned outreach activities of the fellowship stimulating more people to take up the research profession; (ii) in recruiting Dr Owen the fellowship will be attracting a very high calibre researcher into Europe.

Keywords: cognitive science,alcohol hangover
Control for Green Energy-Efficient Technologies (COGENT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2012-12-01
End date: 2015-11-30
Duration (months): 36.0
Total project cost (EUR): 255453.0
EU funding (EUR): 255453.0
Participants: 1
Project status: CLOSED

The EU has set aggressive energy targets that will drive a significant increase in the use of renewable energy sources introducing large uncertainties in the power generation as well as the uptake of plug-in hybrid electric vehicles (PHEVs), offering a new source for balancing the power grid by providing large scale distributed storage capacity. The COGENT project will develop theoretical frameworks and practical tools for applying control and optimization to the energy management of PHEVs that are active participants in the Smart Grid in an interrelated way. Innovative control strategies are required that utilize variable loads and storages to ensure optimal performance and safety of the Smart Grid based on large amounts of data. The proposed project will address this problem by developing novel and sophisticated control and machine learning techniques, that are well suited for the increasingly complex, uncertain, high-speed and distributed characteristics of the Smart Grid. The success of this challenging and highly interdisciplinary program will be enabled by the collaboration with the host institutions, the Control, Intelligent Systems and Robotics group at UC Berkeley, a center of excellence in control and the Max-Planck-Institute for Intelligent Systems, a research group world famous for its work on machine learning. The fellow researcher provides an excellent background for the proposed project, which will be supported by the outstanding expertise of the host institutions, together providing the comprehensive knowledge required for the scientific and technological goals of the program. In addition to the development of high-quality and cutting edge research, the aim of this project is to promote the young outgoing researcher by boosting her skills, expertise and international network. The project will thereby equip the researcher with essential competences and prerequisites for an academic career in Europe and for contributing to European research excellence.

Keywords: optimal control,model predictive control (mpc),smart grids,plug-in hybrid electric vehicles (phevs),optimization,machine learning