Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Towards innovative methods for energy performance assessment and certification of buildings (TIMEPAC)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Germany,Italy,Spain,Austria,Spain,Italy,Cyprus,Slovenia,Croatia,Slovenia
Call: Next-generation of Energy Performance Assessment and Certification (H2020-LC-SC3-EE-2020-2, 2020)
Start date: 2021-07-01
End date: 2024-06-30
Duration (months): 36.0
Total project cost (EUR): 1996586.55
EU funding (EUR): 1996586.55
Participants: 15
Project status: SIGNED

TIMEPAC will contribute to improving existing energy certification processes, moving from a single, static certification to more holistic and dynamic approaches that consider: a) the data generated in the overall energy performance certification process, from generation to storage, to analysis and exploitation, and throughout all the building lifecycle, from design, to construction and operation b) buildings as part of a built environment, connected to energy distribution and transport networks and c) buildings as dynamic entities, continuously changing over time. TIMEPAC will demonstrate the feasibility of combining EPC databases with other data sources to make certification more effective and reliable. The new methods and tools to enhance current certification practices will be developed in five Transversal Deployment Scenarios, and validated in four demonstration scenarios across six European countries: Austria, Croatia, Cyprus, Italy, Slovenia and Spain. The outcomes will be used as training materials to further educate professionals involved in certification processes throughout Europe. An online platform will provide access to training materials and courses delivered in a variety of contexts (onsite and online, blended). A TIMEPAC Academy will further develop and exploit the innovative EPC enhancement methods and tools and the training materials developed in the project.

Keywords: smart readiness indicators,environmental indicators,building renovation passport,data integration
Hydraulic functional traits as determinants of forest function and drought responses. Putting xylem and phloem attributes into the functional trait map. (PHLOEMAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-15
End date: 2018-01-14
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Forests provide key ecological services such as the regulation of energy, carbon and water balances from local to global scale. These are however under severe pressure due to climate and land use changes, especially in the Mediterranean basin where limited water availability is prominent. It is thus crucial to identify the forest species and areas that are likely to be more vulnerable to reduced water availability and establish how changes in forest composition and structure will impact key ecosystem services. In this project, we will use the functional trait concept to bridge between tree, population, species and forest level and as such enlarge our capacity to predict where and when dramatic changes in forest ecosystem services are likely to occur, especially focusing on the role of phloem and parenchyma tissue in tree and forest functioning in relation to drought. Our objectives are to (i) measure phloem and parenchyma traits of 104 populations of 7 dominant tree species in Catalonia and Portugal, study the relationships between these traits and other hydraulic and functional traits and quantify their variability along gradients in water availability, (ii) integrate phloem and parenchyma traits in the theoretical framework describing tree responses to drought, (iii) determine which combination of traits is the best predictor of drought resistance at intra- and interspecific level and (iv) test how and to which extent variability in phloem and parenchyma traits influences forest performance at different ecological scales and forest vulnerability under climate change scenarios. Classical wood anatomy and plant physiology methods will be used as well as novel 3D techniques and recently developed models will be combined and extended. Our results will contribute to the knowledge needed to design effective strategies to deal with climate change. Transferring it to managers and policy makers, as well as to the society at large, is thus a focus of the proposal.

Keywords: functional trait concept,phloem and parenchyma hydraulic traits,xylem hydraulic traits,tree functioning and forest modelling,3d anatomy approach,forest services,drought,climate change
Network of Leading European AQUAtic MesoCOSM Facilities Connecting Mountains to Oceans from the Arctic to the Mediterranean (AQUACOSM)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Germany,Germany,Germany,Norway,Türkiye,Finland,Sweden,Norway,Greece,France,France,Netherlands,Denmark,United Kingdom,Portugal,United Kingdom
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2016-1, 2016)
Start date: 2017-01-01
End date: 2021-08-31
Duration (months): 56.0
Total project cost (EUR): 9999806.57
EU funding (EUR): 9999804.75
Participants: 24
Project status: CLOSED

Experimentation in mesocosms is arguably the single most powerful approach to obtain a mechanistic quantitative understanding of ecosystem-level impacts of stressors in complex systems, especially when embedded in long-term observations, theoretical models and experiments conducted at other scales. AQUACOSM builds on an established European network of mesocosm research infrastructures (RI), the FP7 Infra project MESOAQUA (2009-2012), where 167 users successfully conducted 74 projects. AQUACOSM greatly enhances that network on pelagic marine systems in at least 3 ways: first by expanding it to 10 freshwater (rivers and lakes), 2 brackish and 2 benthic marine facilities, and by involving 2 SMEs and reaching out to more, thereby granting effective transnational access to world-leading mesocosm facilities to >340 users on >11500 days; second, by integrating scattered know-how between freshwater and marine RI; and third, by uniting aquatic mesocosm science in an open network beyond the core consortium, with industry involved in an ambitious innovation process, to promote ground-breaking developments in mesocosm technology, instrumentation and data processing. A new dimension of experimental ecosystem science will be reached by coordinated mesocosm experiments along transects from the Mediterranean to the Arctic and beyond salinity boundaries. These efforts will culminate in a joint research activity (JRA) to assess aquatic ecosystem responses across multiple environmental gradients to a selected climate-related key stressor with repercussions for ecosystem services. Overall, AQUACOSM will fill a global void by forging an integrated freshwater and marine research infrastructure network. Long-term sustainability is sought through assessing governance models based on science priorities and economic innovation opportunities. Linkages to and synergies with ESFRI RI and other large initiatives are ensured by AQUACOSM partners and Advisory Board members in those programs.
Semantics-empowered Wireless Connectivity: Theoretical and Algorithmic Foundations (SONATA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 1991598.0
EU funding (EUR): 1991598.0
Participants: 1
Project status: SIGNED

Wireless connectivity is traditionally viewed as an opaque data pipe carrying content and messages, whose meaning, impact upon receipt, and usefulness for achieving a goal, have been deliberately set aside. This paradigm, although suitable for classical communication, is inefficient and inadequate to support the data-intensive and timely communication needs of networked intelligent systems. Generating, processing, and attempting to send an excessive amount of distributed real-time data, which ends up being stale, redundant, or useless to the end user/application, will cause unnecessary communication bottlenecks and safety issues. The SONATA project envisions a radically new communication paradigm that accounts for the semantic importance of information being generated, processed, and transmitted. In sharp contrast to joint source-channel coding, the communication process starts with data generation at will and active sampling of the source signal. Our key scientific challenge is to pursue the mathematical convergence between signal processing and goal-oriented information transmission by exploiting source/signal properties, process variability, and semantic information attributes. This is a structurally new joint approach, which holds promise to reveal deep connections between sampling theory, communication theory, and real-time systems, for a variety of envisioned wireless networked architectures. A direct gain is the unprecedented reduction in unnecessary data traffic and the associated required communication, processing, and energy resources. The success of the project relies on the establishment of concrete and insightful information semantics metrics and on the development of novel sampling, transmission, multi-criteria scheduling, and real-time source reconstruction techniques. SONATA will transform our fundamental understanding of when, what, and how to process and transmit data, as well as of the actual significance of the information bits communicated.

Keywords: wireless communications,time critical communications,semantic information,real time systems
Transdisciplinary Doctoral Program in Microbiome Science at the University of Naples Federico II (CRESCENDO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2020, 2020)
Start date: 2022-02-01
End date: 2027-01-31
Duration (months): 60.0
Total project cost (EUR): 1627200.0
EU funding (EUR): 813600.0
Participants: 1
Project status: SIGNED

The microbiome is the community of microorganisms inhabiting an ecosystem along with all their genes and it plays a fundamental role in influencing the metabolic fluxes on the biosphere. Microbiome activity is essential for the life on our planet and the well-being of organisms, and research is attracting interest and investment from the industry worldwide. CRESCENDO Doctoral Programme will recruit 10 international Early Stage Researchers (ESRs) who will be involved in research and training in the Microbiome field, leading to a worldwide appreciated PhD degree valuable in terms of ESR career perspectives. UNINA applies for the MSCA-COFUND-DP through its recently established Task Force on Microbiome Studies (www.tfm.unina.it), that combines facilities and experience of more than 150 Academic scientists from 14 different UNINA Departments in the areas of Biology, Medicine, Food and Agricultural Sciences, Chemistry, Pharmacy, Engineering and Social Sciences, thus representing an ideal trans-disciplinary environment to support training and research in the microbiome field. The Programme will benefit of the participation of 21 Partner Organizations (POs) including leading international companies that are stakeholders of the microbiome research and excellent non-academic research centres. Indeed, all ESRs will spend secondment periods abroad and at least 6 months in a non-academic PO, in full integration with their Microbiome-related activities. The POs will have a key role in achieving an international, interdisciplinary and intersectoral (3-i) dimension of the DP. CRESCENDO would represent at this stage the only MSCA-COFUND project for a doctoral programme in Microbiome Science, developing trans-disciplinary Microbiome scientists with intersectoral and international experience and with a multidisciplinary scientific and technical background.

Keywords: microbiome,health,environment,microbiology
Small Signalling Peptides for Stimulating Root Growth - a Novel Approach to Improve Nutrient Use Efficiency (SSPinROOTS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United States,Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 192162.6
EU funding (EUR): 192162.6
Participants: 2
Project status: CLOSED

Plants in the legume (Fabaceae) family are able to fix atmospheric N2 under N-limiting conditions, thereby diminishing the need for N-fertilization. N2-fixation has a high requirement for photosynthates and ATP, and is thus tightly controlled by both the N-availability in the soil and P-level in the plant. Increasing the P-uptake through formation of branched root system and abundant root hairs will increase the N2-fixing capacity and thereby improve the overall nutrient use efficiency (NUE). Small signalling peptides are a largely un-characterized group of regulatory molecules in plants that induce signal transduction pathways upon binding to their complementary receptor signalling modules. Even in the most studied model plant Arabidopsis thaliana only a few of the more than one thousand putative SSPs have been characterized. Very recent work has revealed unique roles of SSPs in alteration of the root system architecture in response to nutrient availability, including the formation of root hairs under P-limiting conditions. Hence, a deeper understanding of the functional roles of SSPs appears to be of key importance for improving NUE. This project aims at advancing our knowledge of SSPs involved in the adaptation to nutrient limiting conditions in legumes beyond current state-of-the-art. This will be achieved using a novel bottom-up bioinformatic approach and unique mutant populations. The scientific objectives are (i) to identify the receptor signalling module and the down-stream target genes in the signal transduction pathway of a newly discovered P-responsive SSP essential for root hair formation, and (ii) to discover unknown N- and P-responsive SSPs in the roots and nodules of the legume model species Medicago truncatula with the aim of (iii) investigating the effect of SSPs on improving NUE. The proposed work will substantially advance our understanding of the functions in which SSPs are involved and will open up for new solutions aimed at improving NUE.

Keywords: small signalling peptides,nutrient use efficiency,legumes,sustainable agriculture
Alteration of Mfn2 protein and Endoplasmic Reticulum to Mitochondria calciUm transfer in STress (aMUST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2022-08-30
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Stress conditions threaten the organism’s homeostasis triggering adaptative responses. One of them is the increased energy demand from the brain. When stress becomes chronic, it leads to behavioural changes that range from adaptation to psychopathology. aMUST project aims to understand the neurobiological mechanisms underlying stress response. Considering that nowadays chronic stress is a risk factor for psychopathologies, such as anxiety and depression, with 25% of incidence in the population and an economical burden of €170 billion/year in EU, the aMUST project is extremely relevant and timely. Mitochondria and bioenergetics are emerging as important key players in stress-related pathologies. Whereas the energy-related impact of stress has received considerable attention in the past few years, the critical importance of the specialized cellular hubs called mitochondrial-endoplasmic reticulum (ER) associated membranes (MAMs) in stress responses, remains to be elucidated. Combining cutting-edge approaches, the aMUST project will shed light on this crucial biological question. Accordingly, intracranial lenses insertion of the mini endoscope in stress-vulnerable brain regions will be used to allow the study of in vivo mitochondrial calcium dynamics during behavioral experiments. 3D electron microscopy, protein ligase assay and BioID in vivo proteomics will allow to determine composition in MAMs structures and which protein interactions are altered during stress. The use of transgenic animals, compounds that change MAMs proteins function and alleviate ER-stress will be used to prevent possible modifications that cause vulnerability to stress. Therefore, aMUST project outcomes will unveil the MAMs-related mechanisms needed to open new therapeutic avenues to promote resilience to stress.

Keywords: stress,anxiety,mfn2,mams,mitochondria
Turn Cancer Immunotherapy Effective in Most Patients (STI-001)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Stimunity is a company that develops disruptive immuno-stimulatory biological drugs to restore the immune system against tumor cells. Immune checkpoint inhibitors showed great potential in cancer immunotherapy after achieving 5-year survival rates for patients with advanced or metastatic cancers, unseen by physicians before. This is a promising beginning. Nevertheless, 5 million patients worldwide remain unresponsive to immunotherapy and do not have any other therapeutic option. On average it represents 50% of all cancers. A promising answer to this problem is the development of new drugs that activate the STING (STimulator of INterferon Genes) pathway, which fires up the innate immune system of these unresponsive patients, inducing a potent and durable anti-tumour immune response. It is expected to be effective on a much larger number of cancer patients. Stimunity’s first product, named STI-001, restores weakened immune systems to kill tumour cells. It is especially effective on distant tumours. Competitors using chemical STING ligands have shown a much weaker immune response than STI-001. STI-001 is based on a safe cutting-edge Virus-Like Particle (VLP) technology that encapsulates the best-known natural STING ligand and efficiently deliver it into immune cells. There is high interest in STI-001, as demonstrated by public and private funding (raised €2.2M to date) and advanced discussions with major pharmaceutical companies (see Letters of Intent). SMEi1 project will allow Stimunity to i) confirm the technical feasibility of manufacturing STI-001, (ii) update the FTO, (iii) assess regulatory issues, (iv) validate the marketing and business plan. Our long-term goal is to develop a pipeline of products based on proprietary VLPs in cancer immunotherapy and create a long term out-licensing strategy as a worldwide leader in VLP-based immunotherapy.

Keywords: sting,virus like particle,cgamp,anti checkpoint therapy,combination,immunotherapy,cancer
Inclusive digital mobility solutions (INDIMO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Israel,Germany,Italy,Italy,Belgium,Hungary,Belgium,Belgium,France
Call: An inclusive digitally interconnected transport system meeting citizens' needs (H2020-MG-2019-SingleStage-INEA, 2019)
Start date: 2020-01-01
End date: 2022-12-31
Duration (months): 36.0
Total project cost (EUR): 2999773.13
EU funding (EUR): 2999773.13
Participants: 15
Project status: SIGNED

The INDIMO project aims to enable researchers, operators, developers and policy makers to include the user perspective and co-creation approaches in the entire development process of digital mobility solutions. This way, products and services delivered would be tailored to the actual needs of transport users. The project will identify the main characteristics of demands that digitally based mobility solutions place on users focusing on all types of transport users and in particular to vulnerable-to-exclusion citizens (older people, children, disabled, poor, low educated). The project will develop the INDIMO Inclusive Digital Mobility Toolbox consisting of the Universal design manual, Universal language interface icons for transport services, Guidelines for cybersecurity and personal data protection and a Policy evaluation tool. The tools will help to develop skills and strategies that can help to bridge the digital divide in terms of social and spatial aspects. The toolbox will be applied and tested on five pilot projects in Madrid (Spain), Antwerpen (Belgium), Emilia Romagna (Italy), Berlin (Germany) and Galilee (Israel).
Supporting mobility of a researcher to undertake their CAROLINE Fellowship (CAROLINE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Action type: Marie Skłodowska-Curie actions
Countries involved: Ireland
Call: MSCA Special Needs Allowance (H2020-IBA-MSCA-SNLS-2019, 2019)
Start date: 2019-08-01
End date: 2021-05-31
Duration (months): 22.0
Total project cost (EUR): 27385.0
EU funding (EUR): 27385.0
Participants: 1
Project status: CLOSED

The Marie Skłodowska-Curie actions pay particular attention to physical accessibility and inclusion and foresee financial support for the additional costs entailed by recruited or seconded researchers with disabilities. This grant will cover the additional costs that the researcher with disabilities face due to the increased mobility cost.

Keywords: impaired mobility,chronic physical problem,ergonomic office furniture,migration,cuba,white colonisation,spanish empire,gender,race,ethnicity,cultural heritage