Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Science Teacher Education Advanced Methods (S-TEAM)

Framework: FP7 — Capacities
Programme: Science in Society
Destination: Strengthening potential, broadening horizons
Action type: Coordination and support actions
Countries involved: Norway,France,France,United Kingdom,Lithuania,Czechia,Lithuania,Denmark,United Kingdom,Germany,United Kingdom,Germany,Spain,Finland,Estonia,Israel,Sweden,Türkiye,Finland,Denmark,Cyprus,France,Germany,Sweden
Call:  (FP7-SCIENCE-IN-SOCIETY-2008-3, 2008)
Start date: 2009-05-01
End date: 2012-04-30
Duration (months): 36.0
Total project cost (EUR): 5240157.84
EU funding (EUR): 4699928.0
Participants: 27
Project status: CLOSED

Helping teachers raise the quality of science teaching and its educational environment has the potential to increase student engagement, attainment, scientific literacy and science career choices. S-TEAM will achieve this by connecting existing science education research and teacher knowledge to teacher education. This task requires the power of coordinated action across a wide range of institutions and national contexts. The 26 partners and 15 nations engaged in S-TEAM have a unique opportunity to systematically integrate their knowledge of teaching, research and teacher education, and to adapt science education to the diverse needs of citizens and the economy in Europe, focusing on inquiry-based methods. These involve problem-solving, hands-on experimentation, authentic, student-led content and critical dialogue, but they require wider development of teacher skills and knowledge. Many teachers are already competent in these methods, and are thus the best source of learning for others. S-TEAM will achieve its aims by disseminating research on, and teachers&amp;apos; experiences of inquiry-based methods to existing and future science teachers. Its actions will involve listening to teachers, working with teacher educators and researchers, and providing support for better science education. This support will include workshops, training packages, video case-studies, teaching materials and publications. S-TEAM will involve not only teachers, but also teacher educators, researchers, students, parents and policymakers in dialogue, to ensure that this dissemination is effective. S-TEAM is sustainable since learning through teacher collaboration and education can be continually regenerated, but also necessary because science teacher education needs to be shared across Europe. By enabling teachers to deliver more efficient and efficacious learning, S-TEAM will improve the attitudes, motivation and learning of young people, including girls, in science education.

Keywords: science teacher education,inquiry-based methods,teacher collaboration,scientific literacy
A Chemical Approach to Lead-free Nanosolders (NANOSOLD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-09-15
End date: 2011-09-14
Duration (months): 24.0
Total project cost (EUR): 232837.57
EU funding (EUR): 232837.57
Participants: 1
Project status: CLOSED

Physical, electronic and thermodynamic properties of small particles (nano-particles) differ significantly from those of the bulk materials, and the depression of the melting temperature below the melting point of the bulk has been known for a long time. This dependence of the melting temperature on the particle size is not restricted to any particular material and may therefore also be exploited to lower the melting temperatures of lead-free solders. At the same time, the high-temperature solders currently in use (melting temperatures 250-400°C) contain high amounts of lead and are exempt from the European RoHS directive due to reliability reasons. In the search for lead-free substitutes, Sn-Sb and Sn-Sb-M alloys have been identified as possible candidates. With the envisaged reduction of the grain size into the nanometer range and a corresponding lowering of the melting temperature, considerable energy savings would become possible in the first soldering step without sacrificing the stability of the obtained solder junctions against re-melting in the further assembling procedure. Therefore it is proposed to prepare micro- and nanosized particles of lead-free high-temperature solder materials, based on Sn-Sb-M (M=Ag, Cu, Ni) from suitable chemical precursors. These precursors will be prepared by precipitation reactions, followed by thermal decomposition and, if necessary, by adequate reduction reactions, and the reaction conditions will be optimized. The particles will be characterized by chemical analysis, SEM and TEM, and by thermo-analytical methods, and the corresponding properties will be compared with those of bulk materials. At the same time, additional experiments in the bulk systems Sn-Sb-Ag and Sn-Sb-Cu will be performed to complete the available literature information on phase diagram and thermodynamics. It will be attempted to model the phase diagrams for bulk and for nano-sized materials by the well known CALPHAD-method.

Keywords: lead-free solder,high-temperature solders,nanosize particles,phase diagram,inorganic chemistry
Investigation of air pollution including gas and PM2.5 distribution over European mega-cities by satellite observations and multi-scale modelling. (AIRPURE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IOF-2008, 2008)
Start date: 2009-04-01
End date: 2012-03-31
Duration (months): 36.0
Total project cost (EUR): 197027.57
EU funding (EUR): 197027.57
Participants: 1
Project status: CLOSED

Particulate matters (PM) have adverse effects with particular efficiency on human health. Climate effects through cloud and aerosol loading are of main importance. The PM physico-chemical behaviour is linked to hazardous air pollutants (HAP) chemistry and depends on emission speciation. Although useful data are provided by air pollution models, lack of knowledge in PM prediction and uncertainties in source emission, still remain. Multiplying field measurements, improving formulations of PM formation in models, are required to reduce these uncertainties for a better support of decision-makers related to policy and emission abatement strategies. The goal of this project consists in gaining new competencies, strengthening specialities in: air pollution modelling and PM2.5 concentration retrieval from satellite observations. The objectives consist in providing a holistic approach of PM2.5 prediction over European urban and regional areas composed by: • providing PM2.5 concentration map over Europe retrieved from satellite observations; • predicting PM2.5 map by improving PM2.5 formulation in existing air pollution multi-scale models; • valorising the candidate experiences and assets in multi-scale modelling and field observations, particularly of PM1 and HAP. In order to achieve such objectives the following tasks will be performed : WP1:Retrieving Aerosol Optical Depths derived from satellite observations and using Harvard techniques to deduce the PM2.5 distribution; WP2:Adapting existing multi-scale Eulerian models by integrating HAP chemistry including VOC/NOx/NH3/O3/SOx and speciated emission data developed under European projects, to provide PM2.5 concentration over European regions. Nesting techniques focusing on urban and regional scales are emphasized for Paris urban areas. WP3:Quality management of the “holistic” air pollution investigation tool: satellite&amp; ground observations combined to multi-scale model results.

Keywords: intercontinental,transport,satellites,voc,ozone,nox,chemistry,ground-based,aerosols,pm2.5,precursors,pollution,model,urban,health,emission,carcinogenic,long-range,policy
Border Security Issues in EU-Russia Relations: Challenges, Perceptions, and Responses (ERBORD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-08-07
End date: 2011-08-06
Duration (months): 24.0
Total project cost (EUR): 237684.37
EU funding (EUR): 237684.37
Participants: 1
Project status: CLOSED

The project will examine the influence of border security issues on the situation at Russian borders with EU members (Estonia, Finland, Latvia, Lithuania, and Poland) and on the EU-Russian relations on the whole. The author would like to estimate the seriousness of border security challenges (drug-trafficking, illegal migration, smuggling in consumer goods, other kinds of transborder crime etc.) and adequacy of their perceptions by decision-makers and public opinion. The project will be resulted in recommendations aiming to improve EU and Russian border policies in respect to the other sides.

Keywords: social sciences,border security,eu-russia relations,transborder cooperation
Use of microbial transglutaminase to reduce egg protein allergenicity (EGGALL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-06-15
End date: 2011-06-14
Duration (months): 24.0
Total project cost (EUR): 172434.64
EU funding (EUR): 172434.64
Participants: 1
Project status: CLOSED

The aim of this proposal is to investigate whether transglutaminase mediated modification can be used to reduce the allergenic potential of ovomucoid and ovalbumin present in egg white. The rising levels of allergies are a serious cause for concern within the European Union, especially in children. Allergic diseases affect between 10-20% of the population and usually start during infancy, childhood or adolescence, and up to 5% children have food allergy (www.foodallergy.org). Food allergies are more prevalent in children, due to an immature gastrointestinal epithelial membrane barrier, allowing more proteins through the barrier and into circulation. Allergy to egg is one of the major allergies in infants and young children. This project will involve studies that could provide important information about how to manage egg proteins hypersensitivity. Modification of proteins by transglutaminase is thought to have beneficial effects on their allergenic properties. Through improved understanding of this effect, we aim to develop strategies for enzymatically modifying the major egg allergens such as ovalbumin and ovomucoid with transglutaminase to reduce the immunoreactivity of these proteins. To achieve this we require a multidisciplinary approach, bringing together the following key skills and expertise: · Biochemistry skills and expertise are required to modify ovalbumin and ovomucoid using transglutaminase and to evaluate the antigenicity (ability of a protein or a peptide to bind an antibody) and the allergenicity of the modified forms. · Physiological expertise is required to define and develop accurate models of protein digestion which are representative of the in vivo situation. In particular models that are relevant to the infant gut where egg allergy is developed. · Immunological skill to use both polyclonal and monoclonal antibodies to study the persistence of potential epitopes through simulated digestion.

Keywords: health sciences,egg allergy,ovomucoid,ovalbumin,transglutaminase
Synthesis of N-hydroxyheterocycles as starvation agents against highly invasive hypoxic solid tumours (NOXYCANCERSTARV)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-07-01
End date: 2011-06-30
Duration (months): 24.0
Total project cost (EUR): 173825.86
EU funding (EUR): 173825.86
Participants: 1
Project status: CLOSED

The purpose of this research project is the development of preclinical anti-cancer drug candidates able to fight hypoxic solid tumours, which are normally resistant to chemotherapy and radiotherapy. Highly invasive tumour cells are characterized by a metabolic switch, known as the Warburg effect, from “normal” oxidative phosphorylation to an increased anaerobic glycolysis. This ensures a sufficient energy supply from glucose, even in hypoxic environments. One of the key enzymes involved in anaerobic glycolisis, the muscle isoform of lactate dehydrogenase (LDH5), has been recently shown to be overexpressed by metastatic cancer cells, and has been linked to the vitality of tumours in hypoxia. This enzyme may be considered as a valid target for new anticancer agents, since its inhibition would lead to a cut in cancer energy supply, thus reducing its metastatic and invasive potential. A validation of LDH5 as a safe target derives from the observation that in humans, hereditary LDH5 deficiency causes a certain level of myopathy only after intense anaerobic exercise, whereas it does not provoke any symptoms under ordinary circumstances. This project will support a qualified international researcher in the management of a research line including molecular design and synthesis of a series of new compounds, as well as in the participation in the biological evaluation of their properties. Each step of his formation will be adequately followed by additional specialized trainers. The host institution has already identified a suitable structural scaffold, based on N-hydroxyheterocycles, which has furnished some preliminary LDH5 inhibitors, comparable to those observed with the few examples known in literature. This scaffold constitutes the basis for the development of a large series of analogues, and thus it increases the chances of finding highly active new LDH5 inhibitors, which will constitute pre-clinical candidates for the treatment of metastatic cancer.

Keywords: medicinal chemistry,anticancer,metabolism,hypoxia,anaerobic glycolisis,warburg,enzymology,lactate dehydrogenase,organic chemistry,synthesis,catalysis,cross coupling,hydroxyheterocycle,click chemistry
Isotopic and Proteomic Approaches to Dehalococcoides Physiology (ISPADEHAL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-09-01
End date: 2011-01-31
Duration (months): 17.0
Total project cost (EUR): 161563.92
EU funding (EUR): 161563.92
Participants: 1
Project status: CLOSED

We apply for a Marie Curie Intra-European Fellowship for Dr. Ernest Marco-Urrea from Barcelona, Spain, to the group of Dr. Lorenz Adrian at the Helmholtz-Center in Leipzig, Germany. The fellowship will allow Dr. Marco-Urrea a significant expansion of his research experience which currently is focused in the aerobic degradation of halogenated ethenes by white-rot fungi. Dr. Marco-Urrea has published four referenced papers on this topic and has acquired research experience in the USA, but the next step in his career is clearly the widening of his thematic focus and of his methodological capacities in a European context. Both will be provided by the host. Dr. Marco-Urrea will continue to investigate microbial biodegradation of halogenated compounds. However, he will cultivate and perform biochemical test consistently under anaerobic conditions; he will work with halogenated aromatics rather than with aliphatics; and he will work with bacteria rather than with fungi. He will expand his already wide spectrum of techniques to the quantitative analysis of stable isotopes and to proteomic approaches. The project will complement the work that is planned in the group of Dr. Adrian on Dehalococcoides-like Chloroflexi. Dr. Marco-Urrea&apos;s main task will be the investigation of the physiological and biochemical characteristics of strain CBDB1 in an isotopic and proteomic context. Strain CBDB1 is a remarkable organism that can transform highly chlorinated dioxins, biphenyls, phenols and benzenes. It is also unique in terms of physiology, morphology and biochemistry, and its genome is fully sequenced. After an initial training phase in which isotope fractionation during growth with perchloroethene will be investigated, Dr. Marco-Urrea will use biochemical and isotopic methods to identify water-soluble electron acceptors for strain CBDB1. In a third phase, an initial proteome map under standard conditions and with alternative electron acceptors will be determined.

Keywords: biodegradation,applied biology,proteomics,dehalococcoides,chlorinated compounds,reductive dechlorination,anaerobic microbiology
Identification of candidate limb type identity determining genes (LIMB-TYPE ID)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-01-04
End date: 2012-01-03
Duration (months): 24.0
Total project cost (EUR): 170733.61
EU funding (EUR): 170733.61
Participants: 1
Project status: CLOSED

Vertebrates have two pairs homologous of appendages, the forelimbs and the hindlimbs. Although these appendages are morphologically distinct, it appears that the genetic networks controlling their development act equivalently in both appendages. While the mechanisms that initiate limb outgrowth and its polarity establishment are reasonably well understood, much less is known about genes regulating limb identity specification. A single gene, the transcription factor Pitx1, has been clearly demonstrated to determine limb-type identity in mouse. Therefore, the transcriptional targets of Pitx1 are excellent candidates to be key of the genetic network leading limb identity determination. By combining mouse molecular genetic methods and microarray screening technologies, I aim to identify novel players of limb-identity determination. We propose to exploit Pitx1 null mouse to undertake a DNA microarray screen. The resulting candidate genes will then be verified, characterised and functionally assessed by complementary approaches using mouse and chick. This work will enhance our understanding of the genetics networks leading to limb-identity specification. More broadly, this project will increase our knowledge of how common signalling cascades acting in a population of progenitor cells are modulated to generate diverse structures.

Keywords: developmental biology,genetics,molecular biology
Supporting the ERA-NET Learning Platform by creating a toolbox for the ERA-NET community (ERA-LEARN)

Framework: FP7 — Cooperation
Programme: General Activities
Destination: ERANET
Action type: Coordination and support actions
Partnership: ERA-LEARN (ERA-NET)
Countries involved: Austria,Ireland,Norway,Germany,Finland,Germany,Türkiye
Call:  (FP7-ERANET-2008-RTD, 2008)
Start date: 2009-01-01
End date: 2011-04-30
Duration (months): 28.0
Total project cost (EUR): 513123.74
EU funding (EUR): 429772.99
Participants: 7
Project status: CLOSED

The ERA-LEARN action will support the urgently needed learning process by generating tools that will be made available to the whole ERA-NET community. The consortium members are themselves fully involved in this funding instrument, being partners in 66% of all ERA-NETs. Thus, this consortium is well qualified to tackle this challenge. Based on a comprehensive analysis of existing and already validated procedures ERA-LEARN will facilitate the identification of recommended tools that are suitable for a broad use. In particular, ERA-LEARN will • facilitate mutual learning among ERA-NETs • provide guidance in aligning and harmonising the structures and procedures needed for efficient and simplified joint call implementation and selection of proposals, with a view to the development of a common framework for these activities • provide guidance in choosing the most appropriate funding mode • provide guidance in taking strategic decisions on which existing ERA-NETs to join and which new ERA-NETs to establish, thereby enabling optimum use of resources and instruments • facilitate a structure for monitoring the long-term evolution of the ERA-NET scheme, helping to create a durable interaction between funding programmes Eventually, the outcome will be a limited set of well accepted and therefore widely used guidelines, serving as a helpful reference and easily accessible library. The ERA-NET community will be enabled to select the most appropriate methods for specific situations.

Keywords: learning platform era-net netwatch guidelines
THE NARRATIVE LYRIC: CONCEPTUAL BLENDING OF SPATIAL SCHEMATA WITH EMOTION IN POETRY AND BEYOND (NARLYR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-IOF-2008, 2008)
Start date: 2009-09-01
End date: 2012-08-31
Duration (months): 36.0
Total project cost (EUR): 225036.19
EU funding (EUR): 225036.19
Participants: 1
Project status: CLOSED

The Narrative Lyric (NARLYR) explores mainly Greek (ancient and modern), English, and Spanish poetry to understand how some basic emotions, such as love, anger, fear, or hate, are integrated with schematic narratives grounded on embodied cognition. This process gives rise to a wide range of products of the imagination, and to a great variety of meanings and forms, all conceiving basic emotional situations and relationships as small spatial events at the scale of a human body. The methodology combines conceptual blending, image schemata, and other analytic tools from cognitive science and linguistics, with more traditional approaches from semiotics, poetics, and classical rhetoric. The main methodological hypothesis is that Fauconnier and Turner’s Conceptual Blending Theory can be productively employed in a systematic contrastive study of the figurative language of emotions, both in poetry and in other usages. In order to model recurrent imaginative patterns, NARLYR proposes generic structures of conceptual integration that build abstract networks capable to analyze a wide variety of examples, ranging from poetic imagery to other artistic manifestations, rituals, religious symbols, or everyday communication. The results expected should challenge the extended conception of the lyric as a non-narrative expression of feelings. As a cognitive poetics enterprise, NARLYR also employs empirical methods to explain literary production and reception in relation with human cognition, and to extend the model from the literary study so that it can contribute to the understanding of emotion language, along with related aspects in communication and art. The fellow will collaborate with leading groups of cognitive scientists, linguists and literary scholars in the US and Spain, under the supervision of Mark Turner, co-author of Conceptual Blending Theory.

Keywords: humanities,narrative emotion,lyric poetry,conceptual blending,image schemata,metaphor,cognitive poetics,cognitive linguistics,semiotics,comparative literature,empirical literary studies