Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Peptide-based Hydrogen Bonding Phase-Transfer Catalysis for Asymmetric Nucleophilic Fluorination (ANFPEP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Asymmetric nucleophilic fluorination remains one of the most challenging transformations in organic chemistry. In light of the importance of chiral fluorochemicals for the pharmaceutical sector, the development of innovative enantioselective fluorination methods with alkali metal fluoride is highly desirable. In this work, we propose to merge two conceptual manifolds, namely peptide-based organocatalysis and hydrogen bonding phase-transfer catalysis. We propose to investigate experimentally the binding ability of an extensive β-turn-based peptide library to fluoride, a fundamental unprecedented study. The insight into the binding profiles and conformational properties of these peptides will be essential for developing an asymmetric catalytic nucleophilic fluorination procedure. In this context, we shall first focus on synthesising pharmaceutically relevant cyclic β-fluoroamines. Subsequently, the peptide-catalyst design will be further refined by introducing a substrate binding region for targeting aryl amides, esters, thioesters, and sulfones. Upon completion, this work will provide medicinal chemists with a novel peptide-catalysed asymmetric nucleophilic fluorination reaction, an advance expanding the scope of organocatalytic nucleophilic fluorination reactions.

Keywords: asymmetric nucleophilic fluorination,organocatalysis,phase transfer catalysis,peptide catalysis
New superconducting quantum-electric device concept utilizing increased anharmonicity, simple structure, and insensitivity to charge and flux noise (ConceptQ)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Finland
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 2498759.0
EU funding (EUR): 2498759.0
Participants: 1
Project status: SIGNED

Quantum technology is an exciting field where new scientific discoveries have great potential to be used in practical applications such as in quantum computing. Although quantum supremacy has been recently demonstrated in fully superconducting qubits, there is a major challenge in promoting these many-qubit processors feasible for technological applications and advanced science experiments: fidelity of all qubit operations well above 99.9% in a power-efficient control and readout architecture is required. This project ConceptQ aims to demonstrate a new superconducting-qubit concept that has a surprisingly simple structure consisting only of standard materials and a single Josephson junction while providing insensitivity to charge and flux noise, and most importantly large anharmonicity. We combine these properties with a new multimode enhancement idea to demonstrate record-breaking fidelities in quantum-logic gates, in initialization, and in readout. Importantly, we introduce cryogenic active components to implement all these three basic operations at millikelvin temperatures thus paving the way for a power-efficient integrated quantum-classical control system. Finally, we use the best new methods and designs for multi-qubit processors and demonstrate a new quantum algorithm at high fidelity. With these breakthroughs, we aim to supersede the transmon as the standard high-fidelity superconducting qubit, thus boosting quantum-technology research and methodology not only in computing but also in sensing and simulation. This potentially opens horizons for novel scientific discoveries in classical cryoelectronics, quantum calorimetry, open quantum systems, and quantum thermodynamics. ConceptQ is a science project, but thanks to on-going collaborations with the quantum industry, it holds great potential for advancement of global wellbeing, e.g., through envisioned long-term applications in cyber security, quantum chemistry, and artificial intelligence.

Keywords: circuit quantum electrodynamics,cqed,superconducting circuit,superconducting qubit,superconducting electronics,cryogenic microwave source,superconducting qubit readout,superconducting qubit initialization,superconducting resonator,transmon qubit,fluxonium qubit,josephson junction,superconducting quantum computer,bolometer,ultrasensitive microwave bolometer,open quantum system,engineered quantum environment,millikelvin electronics
Utilizing AI in Promoting Sustainable Consumption: The Impact of AI-powered Information Presentation and Feedback Interaction on User Healthy and Sustainable Dietary Behaviours (E-Health Management)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 263393.28
EU funding (EUR): 263393.28
Participants: 1
Project status: SIGNED

People have extensively used digital technologies to manage personal health and practice sustainable dietary consumption. The recent emergence of artificial intelligence (AI) provides a more convenient way. The main objective of this project is to address the critical gaps in our understanding of the interplay of AI-powered information presentation, AI interaction (i.e., feedback mechanism), and healthy and sustainable dietary behaviors. Health management has long been a central focus of academic inquiry. While digital health interventions have been extensively studied, there is limited research on the long-term effects of information presentation on user sustainable dietary behaviours from the intelligent system design perspective. To fill these gaps, this project investigates how to use AI-powered applications to guide individuals towards a healthy and sustainable lifestyle in a way that feels natural and unobtrusive, building upon the nudge literature and relevant psychological theories. The project comprises four work packages (WPs). This project will apply a mixed-method approach (i.e., qualitative and quantitative methods) by using experimental methods primarily (i.e., laboratory, online, and field experiments), and employing surveys and interviews as secondary supplementary methods. By collecting data from diverse countries (i.e., Denmark and China), this research can introduce new cross-cultural perspectives (i.e., European and Asian cultures). Understanding how AI can effectively promote behavior change in this context is a novel and impactful area with substantial implications for public health and environmental sustainability. The findings enriches the academic community's understanding of the interaction between digital health management systems and users. It has significant economic implications by promoting the consumption of organic foods, reducing the choices of unhealthy foods, and cutting down the incidence of diet-related diseases.

Keywords: information presentation,ai interaction,user healthy and sustainable dietary behavior,digital health management,green consumer behavior transition,self regulation theory,experiments
SynthAct3D: Pioneering 3D Real-Space Studies of Synthetic Active Matter (SynthAct3D)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Autonomous motion and adaptability of microorganisms in fluids are hallmark features of living systems, fueling the emergence of active matter within the realm of soft matter physics. Notably, micron-sized synthetic self-propelled particles (SPPs) have emerged as a distinct class within this domain due to their unique ability to convert internal energy into directed motion, making them ideal models for studying inherently out-of-equilibrium systems. However, a significant challenge persists: the majority of existing synthetic SPPs are ill-suited for probing the governing principles of emergent collective behaviors observed in living systems, such as swarming, active turbulence, and living clusters, particularly in 3D real space. The ultimate aim of SynthAct3D is to pioneer a paradigm shift, transitioning synthetic active matter from the familiar territory of 2D experiments towards the uncharted terrain of 3D materials with advanced functionalities. This fundamentally driven, experiment-centric proposal seeks to unravel the core mechanisms behind emergent phenomena observed in living systems, employing entirely synthetic units. SynthAct3D focuses on two complementary goals, anchored in a novel experimental framework that combines innovative SPP designs, rigorous characterization, and high-speed confocal imaging: I. Phase behavior a. Investigate the influences of dimensionality (2D Vs 3D) and particle shape on the emergence of self-organization, both structurally and dynamically. b. Elucidate the role of particle propulsion and the microscopic nonequilibrium dynamics in dictating the macroscopic behavior of SPPs in 3D. II. Active materials a. Design reconfigurable 3D active materials (e.g. shape-shifting, and glasses) This research is expected to yield unprecedented insights into internally powered systems in 3D, paving the way for a new class of internally driven materials with applications in reconfigurable soft materials.

Keywords: active soft matter,colloids,self propelled particles,self organization,non equilibrium,artificial microswimmers,3d real space
EcoPack: Sustainable, Edible Plant-Based Packaging Materials (EcoPack)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Estonia
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The global plastic crisis is intensifying, with plastic production projected to double in the next 20 years, leading to a significant rise in plastic waste and environmental pollution. Single-use plastics, particularly in packaging, contribute heavily to marine litter and microplastics, causing severe ecological damage. Existing solutions, such as petroleum-based packaging, are unsustainable, while alternatives like animal-based and seaweed materials face challenges with cost, limited application, and consumer resistance. Decomer Technology addresses this critical issue with EcoPack, a fully plant-based, water-soluble packaging material. EcoPack is an innovative, sustainable solution that dissolves quickly in water, leaving no harmful residue, making it ideal for a range of industries, including food, personal care, and home care. Unlike petroleum-based and animal-derived packaging options, EcoPack offers a compostable, edible, and eco-friendly alternative that aligns with global sustainability goals. The key values of EcoPack include its eco-friendliness, edibility, rapid solubility, and versatility. Its customizable properties make it suitable for various applications while maintaining affordability, scalability, and reducing the overall ecological footprint. By choosing EcoPack, manufacturers can contribute to the reduction of plastic waste and promote a greener, more sustainable future.

Keywords: sustainable packaging material
Miniaturized, scalable and easily configurable deployment system for very large structures, based on a low temperature 3D printing process. (Replicator)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Poland
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The goal of the project is to develop a product for satellites: miniaturized, scalable and easily configurable deployment system for solar arrays, based on a low temperature 3D printing process. High cost of launch to space and limited supply of launch services restrict the growth of the space industry, create barriers to entry that affect mostly new technologies and early stage companies, and remains a significant cost factor in the satellite and space infrastructure development cycle. Orbital Matter is developing a solution that addresses these challenges by offering a compact replacement of complex deployable mechanisms, saving up to 90% of payload volume, which translates to lower launch cost, simplifying the system, which lowers the cost of a platform development, and offering a modular and scalable solution, which shortens lead times and provides more flexibility to the design of satellites, compared to traditional 1kW deployable solar array for satellites. While other in space manufacturing are emerging, Orbital Matter technological superiority is ensured by the combined high precision of their 3D printing process and a utilization of a raw material characterized by low thermal and power requirements. The Company has also proven its agility in qualifying their first satellite for flight in less than 2 years from incorporation, spending less than €0.5m in that period. The Company's product has a potential to impact up to 7000 satellites that are estimated to be launched annually in the next years, offering up to €3B annual saving on the launch cost alone and further resulting from lower component price and simplified integration. Further positive long-term impacts of its technology includes more accessible space industry for new entrants, more sustainable manufacturing by lowering CO2 emissions and less space debris, and fostering the growth of a skilled workforce in advanced manufacturing, robotics, and aerospace engineering in the EU.

Keywords: in space manufacturing,compact deployables,large scale structures,very large solar arrays,antennas,radiators,3d printing
A NATURALLY BASED SMOKING ADDICTION WITHDRAWAL SOLUTION TO HELP SMOKERS QUIT THEIR HABIT (CESTO-III)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Smoking claims more than 8M lives annually globally, driving a demand for rapid, affordable, and effective smoking cessation solutions. Current options, like nicotine replacement therapies and other drugs, face limitations due to poor adherence, side effects and low efficacy. E-cigarettes and heated tobacco products are highly controversial and under the regulatory authorities' scrutiny. Thus, there is a global large market opportunity for a breakthrough smoking cessation solution. NFL-101, a patented, injectable, botanical drug is based on a standardised tobacco leaf extract without nicotine. Its unique mechanism of action leads to exceptional adherence, human safety, and superior efficacy, treating over 10,000 smokers in off-label studies. Progressing through preclinical and clinical trials (Phase I and IIa completed, Phase IIb ongoing), NFL-101 exhibits sustSmoking claims 7,2M lives annually globally, driving a demand for rapid, affordable, and effective smoking cessation solutions. Current options, including nicotine replacement therapies and other drugs, often show limited effectiveness due to poor adherence, potential side effects and low efficacy. E-cigarettes and heated tobacco products are highly controversial and under the regulatory authorities' scrutiny. Thus, there is a global large market opportunity for a breakthrough smoking cessation solution. NFL-101 is a patented, injectable, herbal drug candidate based on a standardised tobacco leaf extract where the nicotine has been removed. NFL-101 works through a novel mechanism of action. Demonstrating unparalleled adherence potential, excellent human safety, and efficacy surpassing that of standard of care products, NFL-101 has successfully treated over 10,000 smokers in off-label studies and advanced through preclinical and clinical trials (Phase I and IIa completed, Phase IIb in progress). In these studies, NFL-101 demonstrated a more lasting and increasing effect, and sustained superiority over placebo.

Keywords: wellbeing,smoking,addiction,tobacco,cigarettes,biosciences,botanical drug,environmental protection
Automated soRting and safE pre-procesSing of EoL BaTteries with nOvel smart and fast dismantling, and sepaRation technolgies for direct reuse of high purity materials in Energy storage application (RESTORE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Spain,Sweden,Germany,Norway,Italy,Belgium,Switzerland
Call: Advanced sustainable and safe pre-processing technologies for End-of-Life (EoL) battery recycling (Batt4EU Partnership) (HORIZON-CL5-2024-D2-01, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 7999189.5
EU funding (EUR): 7999189.5
Participants: 20
Project status: SUSPENDED

RESTORE represents a pioneering research and development initiative, committed to the challenge of designing, developing and deploying a novel holistic and scalable battery recycling process. RESTORE is dedicated to the safe pre-processing of End-of-life (EoL) battery from Electric vehicles (EV) and domestic Lithium-ion Batteries (LIBs), and aims at developing innovative, safe, cost effective and scalable solution for the separation, recovery, purification, upcycling, and validation of materials and metals, to be directly transformed into new battery precursor and functional materials. The proposed solution will shorten the recycling process, while unlocking the recovery of highly valuable materials, currently lost in conventional recycling process, such as the electrolyte, including both the electrolyte salt and solvents, organic binder, graphite and Cathode Active Material (CAM). The project is driven by key industries in Europe, supported by renown research centres, to ensure battery recycling industry will be able to reach the battery directive, and 2030 Critical Raw Materials Act (CRMA) targets. The concept is based on three building blocks: i) Improving upstream processes for the sorting of batteries and the liberation of non-battery materials from EV battery packs and prohibit them from entering in the downstream process, while maximizing their valorisation, ii) Improving pre-processing of battery materials to effectively separate active and non-active battery materials, ensuring high-purity outputs. iii) Improving the downstream process to efficiently separate all battery materials and refine them to battery-grade standards, to be directly reinjected into the battery production value chain. Finally, with the support of LCA and LCCA through SSbD assessment, the most promising routes based on recycled materials will be validated on coin cells. The project's outcomes will be effectively communicated, disseminated, and exploited with stakeholders engagement.

Keywords: end of life batteries,battery recycling,battery active materials,advanced battery sorting and dismantling,black mass,strategic battery material,critical raw material
Power Dynamics in Transformative Social Innovation (POTRANSI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Initiatives around the world are addressiInitiatives around the world are addressing societal challenges by experimenting with social innovations (SI), i.e., new ways of doing, thinking and organising. Examples include sharing economy, eco-communities, participatory democracy and many more. Such SIs can contribute to societal transformation if/when they challenge, alter and/or replace dominant structures and institutions that underly the root causes of societal challenges. To have such a transformative impact, SIs must undergo some form of diffusion, scaling or mainstreaming. In this process, they lose (some of) their novelty and risk reproducing or even aggravating the structures/problems that they meant to challenge in the first place, thereby possibly contradicting their original intentions. This project tackles this innovation paradox from a power perspective by studying how power relations are changed and/or reproduced in processes of transformative social innovation (TSI) and asking how/to what extent SIs are/can be mainstreamed and gain power while upholding transformative potential. We develop a novel power framework that synthesises major power contestations in social and political theory to analyse how actors across different institutional logics (state, market, community, non-profit) gain/lose/exercise/undergo power in TSI. We conduct embedded case studies of 4 SI-trends (sharing economy, eco-communities, decentralised energy, and participatory democracy) at multiple scales, including 12 translocal networks and 12 local initiatives in 3 geographical contexts (United Kingdom, the Netherlands, Portugal), using interviews, participant observation, document reviews and Transformative Power Arena sessions. We design a Critical Power Moments methodology for retrospective analysis of how power relations are (re)produced/transformed over time, as well as a prospective participatory Transformative Power-tool to identify challenges and strategies for powering TSIs.

Keywords: social innovation,transformative change,transformative social innovation,power relations,power dynamics,sustainability transitions