Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ENdoThelial macRophage Alliance In Neuroinflammation (ENTRAIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Italy,Germany,Spain,Italy,Germany,Belgium,Switzerland,Switzerland,Finland,Hungary,France,France,Netherlands,Netherlands,Netherlands
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-05-01
End date: 2023-04-30
Duration (months): 48.0
Total project cost (EUR): 3664173.96
EU funding (EUR): 3664173.96
Participants: 20
Project status: SIGNED

Neurological diseases cause enormous suffering and a great economic burden. Almost 20 million Europeans are affected by the most frequently occurring and disabling disease entities, such as stroke, Alzheimer’s disease (AD), or multiple sclerosis (MS), and these numbers do not include the large group of rare diseases that affect the CNS. Overall, the annual costs for patient care amount to 400 billion Euros. Common features of many neurological diseases are a vascular pathology with impaired blood-brain barrier (BBB) function or with reduced blood flow and inflammatory changes. As the two are often associated, disentangling their intricate and mutual relationship is a major task for translational neuroscience that could improve the treatment of many neurological diseases. At the cellular level, key players are brain endothelial cells as the building blocks of cerebral vessels and macrophages as the main inflammatory cells of the brain. Recent discoveries indicate that endothelial cells and brain macrophages are in intimate contact and closely interact. However, there is a huge gap of knowledge regarding the specific mode and the consequences of these interactions. Therefore, in-depth analyses of the molecular mechanisms involved are essential to identify and understand key features of macrophage-endothelial cross-talk, and exploitation of this information for the development of treatments of neurological diseases. ENTRAIN will undertake this task, using novel and emerging technologies, such as cutting-edge chemoproteomics, unique genetic and viral tools for targeting of defined cell populations, and high resolution intravital imaging. By characterising the pas de deux of endothelial cells and macrophages at the functional and morphological level, we will lay the foundation for better therapies for neurological diseases. The results will impact on the understanding of neuroinflammation, but also on the rarefaction of vessels.

Keywords: stroke,multiple sclerosis,alzheimer s disease,endothelial cells,macrophages,microglia,neurological diseases,blood brain barrier,experimental autoimmune encephalomyelitis
Conductive elastomers with tuneable properties for smart wearable electronics. (TEXTHIOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Organic conductive polymers are gaining increased interest each day due to their broad applications, low cost and ease of manipulation. Their potential to develop new products that will transform the daily lives of people in Europe and around the world is significant. Among the application areas with the highest potential, smart textiles provide one of the most futuristic and innovative potential products. At present, a conducting polymeric material that can be use directly as textile does not exist primarily a consequence of the poor (brittle) materials properties of conducting polymers. Any such products are created by coating of the conductive material onto the textile or tissue. However the ability to use polymers to create wearable electronics has transformative potential to become a disruptive technology. This proposal aims to create a conductive polymer with elastomeric properties such that it has enhanced materials properties and can therefore be applied directly as scaffold for smart textile creation. To make the polymeric scaffold, the nucleophilic thiol-yne “click” reaction between an activated alkyne and thiol will be used. This pathway will enable retention of the electrical conductivity while presenting the possibility to tune the mechanical properties by choosing the stereochemistry (E/Z) of the unsaturated bond that is formed. Moreover, the elastomeric nature of the resultant materials, presents a unique opportunity to create conductive elastomers that can be easily applied to wearable electronics: able to record electrical signals such as heartbeats or muscular contractions. The project is going to combining the organic synthesis and click chemistry expertise of Mantione with that of conducting polymer synthesis and characterization of Prof. Hadziioannou. The planned secondment is aiming to allied to the expertise of Prof. Malliaras (Cambridge, UK) in wearable electronics: biotest the materials and practically create the textile.

Keywords: organic conductive polymers,thiol yne click reaction,wearable electronics,smart textile
The World´s First Application-Aware Network: Enabling Dynamic Bandwidth Management and Guaranteed Data Connection Quality in Mobile Networks (AWARENET)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Finland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 2291125.0
EU funding (EUR): 1603787.5
Participants: 1
Project status: CLOSED

Unmet challenges related to explosive demand for mobile internet data volumes pressure the telecoms and interrupt the service quality for end-users. Cloudstreet is now commercialising a unique Dynamic Profile Controller™ (DPC) solution for smart optimisation of limited bandwidth resource in current and forthcoming LTE networks. The disruptive innovation enables to identify the exact data need for each internet connected device or application on-the-fly and deliver the required bandwidth accordingly. The Cloudstreet DPC enables the world´s first consumer ready Application Aware Network solution. The DPC solves challenges for telecoms´, web-service providers and mobile internet end-users: • Meets the rapidly increasing mobile data demand by smart bandwidth management • Gives end-users´ 99.99% service reliability and guaranteed connection for even to most data-demanding tasks in mobile networks • Unlocks the huge potential of web services and smart innovation, especially in busy urban centres or in remote areas • Monetises the increasing data volumes and creates 50% revenue income potential for telecoms • Provides tools for achieving Net Neutrality goals and building capable 5G networks for minimum costs and risks The AWARENET project marks a key phase in Cloudstreet´s road to market clearance. It aims to achieve DPC architecture scale-up and create standardised integration solution for most telecoms globally. As a key task in the project, Cloudstreet will pilot the DPC within 5 Central-European networks to achieve market validation in the targeted consumer and business segments. As a direct result of the AWARENET project, Cloudstreet will unlock the EU markets that will create disruptive spill-over effect on other regions and application areas. By 2020, Cloudstreet aims to be the global leader in Application Aware Network solutions, providing universal dynamic bandwidth management solution for over 100 LTE networks and 7 million end-users globally.

Keywords: application aware network,mobile networks,dynamic bandwidth management
A redox-neutral process for the cost-efficient and environmentally friendly production of Menthol (NEUTRAMENTH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Austria
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-10-01
End date: 2020-12-31
Duration (months): 27.0
Total project cost (EUR): 149996.25
EU funding (EUR): 149996.0
Participants: 1
Project status: CLOSED

Menthol is an organic compound which ranks as the world's most popular flavour due to its uniquely fresh taste. It is present in a myriad of everyday products, from shower gel to toothpaste to cooling ointment. It is most widely produced industrially from Citronellal in a sequence of metal-promoted cyclisation followed by precious metal-catalysed hydrogenation. The use of metals in synthesis presents issues associated with cost, environmental friendliness and product contamination. In the ERC CoG project VINCAT, the group of Prof. Maulide has made groundbreaking discoveries in redox-neutral transformations and has uncovered a carbon-carbon bond forming reaction that allows the production of Menthol from Citronellal in a single step and without the need for any metal-catalyzed event. The goal of this PoC project is to optimize the metal-free conversion of Citronellal to Menthol in a single step, to demonstrate technical feasibility and implementation on large scale and to implement the relevant market analysis and IPR strategy.

Keywords: organic chemistry,synthesis,metal free
Millimetre wave Gallium Nitride Space evaluation and application to Observation Satellites (MiGANSOS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Research and Innovation actions
Countries involved: Italy,Finland,France
Call: Technologies for European non-dependence and competitiveness (H2020-COMPET-2017, 2017)
Start date: 2017-11-01
End date: 2021-12-31
Duration (months): 50.0
Total project cost (EUR): 2936927.5
EU funding (EUR): 2936927.5
Participants: 4
Project status: CLOSED

MiGaNSOS proposal targets its activities to address the following objectives: · First Objective is to assess and space-evaluate a "state of the art" GaN/Si process for open foundry use, which will lead to new industrial products greatly influencing European companies’ competitiveness. The process to be evaluated is the 100 nm GaN/Si technology developed by OMMIC; a preliminary evaluation will also be performed on the 60 nm GaN/Si process as being optimized by OMMIC as the natural extension for higher frequency applications. This objective shall be realised via the realisation of test vehicles dedicated to the evaluation process and basic monolithic functionalities such as Low Noise Amplifiers (LNAs), High Power Amplifiers (HPAs) and Single-Pole Double-Throw Switches (SPDT) and their Single-Chip integration (Single-Chip Front-End, SCFE) as demonstrators of the technology. · Second Objective consists in the demonstration of the simultaneous use of 100 nm and 60 nm GaN/Si technologies. This opens up the possibility to use them not only for the realization of the same wafer run but also within the same circuit, Such unique feature, unprecedented to date in available commercial foundry processes, represents a real technological breakthrough, increasing circuit design flexibility and resulting circuit performance. · Third objective of MiGaNSOS resides in the demonstration of future application of the developed technologies in advanced space equipment. In particular, a Ka Band Synthetic Aperture Radar (SAR) antenna shall be taken as reference and the fully integrated SCFE shall be integrated in a demonstrator replicating the basic building block of the Ka Band active antenna. · Finally, the fourth objective consists in disseminating the obtained results, making available the evaluated technology to the scientific and industrial communities and addressing new market opportunities

Keywords: gan process for space application
Perceptive Sentinel – BIG DATA knowledge extraction and re-creation platform (PerceptiveSentinel)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Research and Innovation actions
Countries involved: Austria,Slovenia,France,Denmark
Call: EO Big Data Shift (H2020-EO-2017, 2017)
Start date: 2018-01-01
End date: 2020-06-30
Duration (months): 30.0
Total project cost (EUR): 1983187.5
EU funding (EUR): 1983187.0
Participants: 6
Project status: CLOSED

PerceptiveSentinel project will deliver PerceptiveSentinel platform - an INTERMEDIATE EO service that will through seamless access to highly pre-processed DATA provide: - MODELLING and PUBLISHING capabilities for - DESIGN, EXPOSURE and EXPLOITATION of EO-processing chains for - FORECASTING, MONITORING and HISTORICAL ANALYSIS in different domain fields, based on - MULTI-TEMPORAL and MULTI-SPECTRAL EO-Data and Non-EO Data MODELLING. PerceptiveSentinel platform will combine BIG-DATA SOURCES, (2) both spatial and non-spatial, (2) whether remote sensed, observed in-situ or derived (3) whether public, private or proprietary—onto a single system. The data will be transformed into action by applying STREAMING MACHINE LEARNING to UNLOCK its value. Platform’s capabilities will significantly shorten development cycles, enabling rapid development of EO services, opening new opportunities for large-scale exploitation of data and provide the means for new EO “downstream players” to smoothly enter the market without the investment into their own storage and processing capabilities. Commercialisation approach will be based on (1) FREE and OPEN access to services and data, (2) OPEN-VALUE-CHAIN approach, (3) LOW COST of services and on (4) DELIVERING VALUE TO END USERS. It is our intention that PerceptiveSentinel platform becomes FIRST value and benefit sharing EO platform in the world. We intent to expose an alternative business model building on COOPERATIVE VALUE CREATION and capture, including all aspects of EO value chain from data providing, product/service development, publishing and consuming. We believe in synergetic effects of cooperation, using PerceptiveSentinel platform to establish alliances with external partners, taking an open approach to participation and building joint commercial success on the delivery of new added value.

Keywords: streaming machine learning,publishing
MALDI-TOF mass spectrometry metabolite screening assays for drug discovery in human disease (HTS MALDI-TOF MDD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-07-12
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Discovery for drug targets is a key step within the process of drug development, and is the corner stone in the pharmaceutical industry. This is mostly achieved by high-throughput screening (HTS) approaches in which a large number of chemical substances are assayed for a specific effect or activity in diverse areas of biology. Mass spectrometry (MS) has become a widely adopted tool in this field as it offers the possibility to simultaneously track molecules in a label-free manner, provides excellent signal to noise, reproducibility, assay precision, and a significantly reduced reagent cost when compared to fluorescence-based assays. Matrix-assisted laser/desorption ionisation time of flight (MALDI-TOF) is the most validated surface ionisation method for HTS approaches, but reported applications of this technology have been limited to in vitro assays with simple readouts and to peptide/protein-centric activity assays. To date, comprehensive and unbiased metabolomics based HTS approaches for cellular assays with MALDI-TOF have not been explored. The objective of this fellowship is to set up a MALDI-TOF based cellular assay for HTS metabolomics drug discovery in order to identify a set of metabolites to screen which will enable us to unbiasly and comprehensibly measure, in a HT manner, how drugs affect different metabolic pathways while simultaneously mapping the metabolic profile of the cell. First, I will develop a robust protocol for the detection, identification, and quantification of ~50 small metabolites for cellular assays. Then, I will apply this protocol to track metabolites in a pulmonary fibrosis cellular model, as well as in fibrotic lung tissue sections using MS imaging. The goal is to compare a disease model with the control to see how drugs are affecting these metabolites, and to see if identified biomarkers can be used to identify disease in tissue samples. As a final validation step, I will implement this platform in Boehringer Ingelheim in Germany.

Keywords: maldi tof,high throughput screening,drug discovery,mass spectrometry,mass spectrometry imaging,untargeted metabolomics
NITEC: a Negative Ion Time Expansion Chamber for directional Dark Matter search (NITEC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-04
End date: 2017-05-03
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The goal of this project is the construction of a Negative Ion Time Projection Chamber (NITPC) with triple Gas Electron Multiplier amplification and pixel readout (GEMPix) for directional Dark Matter (DM) searches. DM is 5 times as prevalent as normal matter in the Universe, but its identity remains unknown. Its mere existence implies that our inventory of the basic building blocks of nature is incomplete: deciphering its nature is one of the most compelling tasks for fundamental physics and astronomy. Weakly Interacting Massive Particles (WIMP) are well motivated DM candidates, independently predicted by Standard Model extensions and Big Bang cosmology. Direct detection experiments aim at observing very low energy (10-100 keV) nuclear recoil of WIMP scattering in the matter. While today leading experiments have managed to reach excellent rejection for electromagnetic components, other background sources (such as neutrinos and environmental radioactivity) will forbid to even think larger mass next-generation detectors without a drastic change in technology. We believe that the combination of the large volumes and improved position and energy resolution provided by the negative ion technique, together with the excellent performances of the GEMPix can offer a significant contribution to this research field. In a NITPC, negative ions drift rather than free electrons, drastically reducing diffusion thanks to their higher mass. This is why we want to combine for the first time this idea with one of the most advanced readout, the GEMPix: a triple GEM detector coupled to a Medipix ASIC board, able to provide excellent spatial, energy and time resolutions. Its sensitivity to single ionization cluster will allow this NITPC, together with the slow motion of the anions, to function effectively as a Time Expansion Chamber, hence NITEC. It's worth noticing how NITEC could work also as neutrinoless double beta decay detector, X-ray polarimeter and microdosimeter for hadrotherapy.

Keywords: dark matter dm,time projection chamber,rare events,gas electron multiplier gem,dm directional detection,negative ion
Complex photon-phonon coupling (COPPOLa)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

When humans design devices to perform a given functionality, we often prioritize ordered patterns and symmetry over anything else. Optomechanics is a clear example where precisely fabricated nanometer-scale devices are required to interface efficiently light with the mechanical vibrations of matter at the nanoscale. This coupling provides an extra degree of freedom to control the light-matter interaction. In state-of-the art optomechanical crystals, unavoidable fabrication imperfections impose severe performance limits increasing the energy dissipation and hampering their optical and mechanical performance. Disorder and randomness are ubiquitous in nature. Complex biological systems are clear examples where the functionality is not optimized through symmetry. In fact, disorder and complexity can also be exploited as a resource instead of being suffered as a nuisance. But, even when considered detrimental, understanding the role of fabrication imperfections is crucial to avoid its dramatic impact in state-of-the art structures. In this action, we propose to study the role of fabrication imperfections in state-of-the art optomechanical crystals by deliberately introducing disorder in one- and two-dimensional structures. Our aim is to analyze the role of disorder by quantifying the coupling strength between photons and phonons vs. the amount of disorder, something so far unexplored in optomechanics. Furthermore, we want to investigate if the mechanical action of light is enhanced deep in the Anderson localization regime, as it has been proposed theoretically very recently. Understanding and quantifying the effect of disorder is crucial to reduce its impact but we can also use it to our benefit. The cutting-edge research proposed here can offer innovative solutions to open issues in different scientific disciplines ranging from cavity optomechanics at room temperature to spintronics, thermal conductance and micro-electromechanical resonators at very low temperatures.

Keywords: optomechanics,multiple scattering,anderson localization,thermal conductance