Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovation for Sustainable Sheep and Goat Production in Europe (iSAGE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Spain,Spain,Italy,Italy,Spain,Spain,Spain,Spain,Italy,Türkiye,Türkiye,Greece,Finland,Türkiye,Türkiye,Türkiye,Greece,Greece,France,France,France,France,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Assessing sustainability of terrestrial livestock production (H2020-SFS-2015-2, 2015)
Start date: 2016-03-01
End date: 2020-02-29
Duration (months): 48.0
Total project cost (EUR): 6996922.0
EU funding (EUR): 6996922.0
Participants: 36
Project status: CLOSED

iSAGE will enhance the sustainability, competitiveness and resilience of the European Sheep and Goat sectors through collaboration between industry and research. iSAGE have a powerful consortium with 18 industry representatives from various EU production systems and socio-economic contexts. The sheep and goat sector will be investigated because it is sensitive to general socio-economic, demographic, and ecological and market challenges; nevertheless, the project’s approach and results will be made available and disseminated to other EU livestock industries. Therefore, at the core of iSAGE is a participatory approach centered on a multi-actor internal and external communication (WP) to build the project from the farmer level. This approach will ensure relevant issues are addressed and the project outcomes are applicable in practice and create a farm-level observatory and knowledge exchange network on the sustainability of livestock. This WP will also assist three assessment work packages that will deal with the sustainability assessment of sheep and goat farm systems and related supply chains, with socio-economic demographic and consumer trend analyses, and with the impacts of climate change. Assessment WPs will inform action WPs that will: (1) redesign holistic farming systems to best reconcile the various demands concerning productivity, sustainability and societal values. (2) identify industry solutions that aim to improve sustainability and productivity of sheep and goat systems through breeding, including new phenotypes linked to sustainable animal productivity. iSAGE, together with stakeholders and end-users, will draft a roadmap for further research and policy making. The stakeholder groups will be the key players in disseminating project outputs through case studies and demonstrations to act as a blueprint to other producers across Europe and create networks to assist wider implementation of iSAGE outputs.

Keywords: sheep,goats,sustainability assessment,socio economic,demographics,consumer trends,climate change,livestock systems,breeding programs,innovation,action,participatory research
Determing symbiont factors that affect compatibility with a novel host (Symbcompat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Symbiosis between multicellular organisms and microbial symbionts is near universal, and it is now clear that many aspects of organismal biology in health and disease cannot be understood without reference to interactions with microbes. In insects, this includes a diverse range of heritable symbionts, which pass from a female host to her progeny. These symbionts are highly adapted to their host, and encode important properties, such as defence against natural enemies. In contrast to classical adaptive phenotypes, symbiont traits generally arise through a host shift event – the movement of a microbe from into a novel host species. Experimental host shift experiments indicate that there is a compatibility filter: some symbionts in novel host species cause little pathology and transmit vertically efficiently, whereas other do not. Understanding this compatibility filter will clarify the patterns through which host shifts occur in nature, and create a principled basis for manipulation of compatibility, for instance in symbiont-mediated control of vector competence. In this proposal, the causes of poor symbiont-host compatibility will be established for the first time. We will first examine what symbiont/host systems malfunction in a poorly performing symbiosis, examining whether phage lysis or illegitimate toxin production affect symbiont titre and virulence in the novel host. We will then determine the genetic basis of symbiont compatibility using a novel experimental evolution approach. Symbiont compatibility is known to increase on passage in novel hosts, and the proposal will use comparative genomics of evolved vs ancestral symbionts to establish the loci that are subject to selection during the evolution of compatibility. The results of this project will impact both upon our understanding of an important natural process and enable better exploitation of symbiont encoded traits in control of vector born disease.
A Quantitative Approach for Smart Parking (QPARK)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Portugal
Call: FET Innovation Launchpad (H2020-FETOPEN-4-2016-2017, 2017)
Start date: 2018-09-01
End date: 2020-02-29
Duration (months): 18.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Ubiwhere has been commercialising a low-cost, seamless and straightforward-to-install system entitled Smart Parking, composed of vehicle-detection electromagnetic sensors and an intelligent software platform to collect and process all the data. Through this system, parking operators can enhance their ongoing operations by knowing in every instance what is happening and by analysing reports on the behavioural patterns detected by the platform, improving their operational and enforcement efficiency. The potential market of Parking has increased the number of competing solutions in this sector (despite the lack of a market leader), composed of both ICT startups and well-established companies. With so many competitors, and taking into account that several cities have started to dismantle the spaces reserved for parking in their urban areas, Ubiwhere intends to enrich its Smart Parking platform with urban planning capabilities, unlocking a new business opportunity and consequently standing out from its competitors. QPARK aims at up-scaling the current Smart Parking solution, enriching it with a new service (feature) that enables the generation of reports via a thorough analysis of which areas of the city are more affected by certain events and how that sudden increase in people affects the city traffic and the parking occupancy. The FET Open project QUANTICOL will support this what-if analysis by providing the necessary tools and mechanisms to advance in the problem space and provide useful knowledge quickly. QPARK will allow Ubiwhere, a software company focused on Smart Cities and Communities, to disrupt the global market by enriching its solutions with urban planning capabilities, powered by complex adaptative systems developed in QUANTICOL.

Keywords: smart parking,smart cities,complex adaptative systems
An affordable Multi-analyte Point-of-Care system for Chronic Disease Self-Control and Management (PoCMICRUX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Longer life expectancies and unhealthy lifestyle has dramatically increase the prevalence multiple chronic conditions. There are over 50 million of people with such cumulative chronic conditions in Europe and, together, they total more than €700 billion healthcare expenditure which account for over 70% of the EU health budget. Recent Point-of-Care Testing (PoCT) technologies provide remarkable tools for home self-testing and management but the currently PoC on the market are still so complex and too expensive to be afforded by average patients. With PoCMicruX we intend to overcome this barrier and finally provide patients the first low-cost multi-analyte handheld Point-of-Care device for multiple chronic disease self-testing and management. PoCMicruX is a combination of microfluidic and electrochemical sensor technologies. Based on an innovative design totally made of electronical components and where fluid can simply be handled by capillary action, we will offer the only cost-effective (€150), simple (one drop of blood, no training or calibration required), fast (<2 min), and handheld PoC device allowing patients to accurately self-test simultaneously four clinical validated biomarkers (glucose, cholesterol, creatinine and uric acid) for the clinical diagnostic (monitoring and prevention) of high prevalence diseases such as diabetes, cholesterol, cardiovascular and kidney diseases. MicruX Technologies is a highly innovative Spanish company that, from its foundation in 2008, has been at the forefront of developing miniaturized lab-on-chip technology and miniaturized monitoring instrumentation, being already involved in several EU projects. We have already succeeded in launching more than 30 models of products currently marketed in 40 countries. We expect from PoCMicruX commercialization to provide an accumulated turnover of €26.7 million by 2023, with 8.5 million profit (profitability ratio of 57%). We foresee to create 50 new jobs by 2023.

Keywords: point of care,microfluidics,lab on chip,home care,chornic diseases,diagnostic device,diabetes,cholesterol,kidney disfunction,cardiovascular condition,glucose,creatinine,uric acid
Robotic REHabilitation Orthosis (REHO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2019-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

REHO will revolutionize the market of rehabilitation with the first robotic system composed by an active electropneumatic exoskeleton for lower limbs exercises in different operational conditions (on the ground or fully unloaded) able to entirely stimulate a proper motor cortex activation, re-establishing walking functions in brain-damaged patients. REHO system is designed for the rehabilitation of patients with clinical problems such as hemiplegia, tetraparesis and hemiparesis, as well as those who have suffered strokes, ischemias or cerebral hemorrhages. Stroke is the first leading cause of disability in Italy (196.000 patients every year) and the second leading cause in Europe. In the EU27 countries, the annual economic cost of stroke is an estimated €27 billion. The market for robotic rehabilitation is currently growing strongly with a CAGR estimated at 24% in 2016-2020, with the segment of lower limb rehabilitation robots expected to reach $ 2.1 billion in 2020. REHO main advantages: i. it is applicable to many clinical situations, ii. it offers a very good wearability and minimal invasiveness, iii. it can be used for both suspended and over ground walking, iv. its structure is innovative and light, v. it is safe and comfortable thanks to pneumatic actuators, vi. it provides ankle joint actuation, essential for patient’s motor cortex activation, vii. it includes a versatile hardware and software with user-friendly graphical interface and easy-to-use emergency controls for operator and patient, viii. it is an affordable “all in one” solution. Even though some potential competitors do exist, they are suppliers of systems featuring lower technical performances (expensive, heavy, large and are blocking the free movements of the patient) as well as higher operational costs. For these reasons there is the need to introduce an automated system like REHO to motivate patients, dramatically improving their motor abilities.

Keywords: exoskeleton,rehabilitation,lower limbs pathologies,gait,locomotor function,cortex activation,robotic medical device,central nervous system
Pink Salmon Invasion of the North Atlantic: Evaluation of Stable isotopes as a method to detect potential impacts (PinkSIES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Biological invasions threaten global biodiversity and cause billions of Euros of damage to the European economy annually. The recent invasion of northern Europe by Pacific pink salmon, Oncorhynchus gorbuscha (Walbaum), has attracted much attention. Introduced into rivers of the White Sea by the USSR in the 1950s/1970s, a sudden dramatic increase in occurrence was observed around the North Atlantic in 2017. Negative impacts on native Atlantic salmon stocks are expected, including competition for food at sea, with economic implications for member states. The aim of this project is to determine the impact of pink salmon on native salmonids both at sea and in recently invaded rivers by determination of the distribution of pink salmon feeding grounds in the North Atlantic, assessment of competition with Atlantic salmon at sea, determination of field metabolic rates (hence thermal sensitivity) of both salmon species, prediction of future marine distributions, and evaluation of the ecological role of pink salmon fry in recently-invaded rivers. To achieve these aims, stable isotopes of material from pink salmon (otoliths, scale and muscle tissues) will be analysed, along with gut contents of juveniles and predators. Whilst stable isotopes have been used to study the distribution of salmon in the oceans, this is the first time that the approach will be used to assess the impact of an invasive fish species on native species at sea, as well as application of a novel otolith derived isotope proxy to establish their sensitivity to global warming. There is little research on the ecology of pink salmon fry in invaded rivers. The proposed fellowship is a holistic study of this invading species: the results will expand our knowledge of the environmental biology of this invasive species in Europe and provide a scientific basis for decision-makers responsible for protecting the wild Atlantic salmon stocks.

Keywords: invasive alien species,salmon,anadromous fish,stable isotopes,marine distribution
Vibrational Spectroscopy for Molecular Crystals via Quantum-Mechanical Embedding Methods (VibMolCryst)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-01
End date: 2022-06-30
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: CLOSED

By this project, the routine calculation of anharmonic vibrational spectra and properties for practically relevant molecular crystals will be enabled via the usage of a quantum-mechanical (QM:QM) embedding approach. All monomers and relevant dimers are treated with a high-level method, while the fully periodic system is considered at a lower level. Highly accurate vibrational spectra can be obtained for small molecular systems with benchmark CCSD(T) utilizing second-order vibrational perturbation theory (VPT2) only with a computational cost prohibitive for routine applications involving larger systems. Therefore, the applicant will create a diverse benchmark set of monomers and molecular dimers covering a wide range of intermolecular interactions and subsequently benchmark the performance of various dispersion-inclusive density functional approximations (DFA) against CCSD(T) for vibrational properties calculated with VPT2, independent Morse oscillators, and the harmonic approximation. Next, the QM:QM embedding approach for molecular crystals will be extended from available gradients to the calculation of harmonic vibrational spectra, which will already enable the usage of hybrid DFAs at a cost comparable to the generalized-gradient approximation. Subsequently, VPT2 calculations for monomers and dimers will be incorporated in the embedding scheme and the accuracy of the so obtained anharmonic vibrational spectra will be assessed for a variety of molecular crystals using promising DFAs identified during the first stage of the project. This methodology will be computationally affordable for practically relevant molecular crystals and is expected to aid peak assignments and interpretation of low-frequency THz spectra—used for instance for the detection of explosives. This approach is also expected to increase the accuracy of calculated thermodynamical stabilities, which is critical for drug development since existing molecular crystal polymorphs are almost degenerate.

Keywords: density functional theory,coupled cluster,vibrational spectroscopy,molecular crystals,vibrational perturbation theory,quantum mechanical embedding methods
Sexual and Gender Non-Normativity in Opera after the Second World War (NONORMOPERA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2024-05-02
Duration (months): 36.0
Total project cost (EUR): 255768.0
EU funding (EUR): 255768.0
Participants: 2
Project status: CLOSED

In the late 1970s, North-American musicology inaugurated the exploration of the ways in which gender and sexuality affect musical expression. Since the development of queer theory in the early 1990s, a new orientation has manifested in musicological research. Musicology that integrates queer theory – most briefly defined as ‘Queer musicology’ – considers music the site for the confrontation between heteronormative dominant culture and the composer’s non-normative gender identity, who questions social prejudices on grounds of sexual and gender diversity through his art. Research in this recent trend is very productive in North-America, but it has developed less in Europe. Despite the flourishing of this field in small-scale studies across many genres, there are yet few book-length studies of coherent repertoire. The project is unique in queer musicology in its focus on opera. By comparatively investigating eight operas premiered between 1945 and 2000 by gay composers of various ages, nationalities, educational backgrounds and musical styles, it will shed light on the expressive strategies employed by authors to represent sexual and gender non-normativity. The overall objective will be reached through the developing of three specific objectives: I) to relate the representation of sexual and gender non-normativity to the self-perception of his non-normative identity by the author, on the one hand, and to the perception of sexual and gender non-normativity by the socio-historical context where the opera was composed on the other; II) to identify the aspects of the libretto that refer to sexual and gender non-normativity; III) to identify the musical elements that contribute to the expression of sexual and gender non-normativity. Through the inquiry into how gay composers use operatic genre to explore non-normative genders and sexualities, the project will highlight how music can relate experiences of marginalisation and challenge discriminatory prejudices.

Keywords: twentieth century opera,queer musicology,gay composers,francis poulenc,samuel barber,hans werner henze,michael tippett,sylvano bussotti,gian carlo menotti,thomas ad s,peter maxwell davies
Defining the role of the FGF – autophagy axis in bone physiology (BONEPHAGY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Italy
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 1586430.0
EU funding (EUR): 1586430.0
Participants: 1
Project status: SIGNED

Autophagy is a fundamental cellular catabolic process deputed to the degradation and recycling of a variety of intracellular materials. Autophagy plays a significant role in multiple human physio-pathological processes and is now emerging as a critical regulator of skeletal development and homeostasis. We have discovered that during postnatal development in mice, the growth factor FGF18 induces autophagy in the chondrocyte cells of the growth plate to regulate the secretion of type II collagen, a major component of cartilaginous extracellular matrix. The FGF signaling pathways play crucial roles during skeletal development and maintenance and are deregulated in many skeletal disorders. Hence our findings may offer the unique opportunity to uncover new molecular mechanisms through which FGF pathways regulate skeletal development and maintenance and to identify new targets for the treatment of FGF-related skeletal disorders. In this grant application we propose to study the role played by the different FGF ligands and receptors on autophagy regulation and to investigate the physiological relevance of these findings in the context of skeletal growth, homeostasis and maintenance. We will also investigate the intracellular machinery that links FGF signalling pathways to the regulation of autophagy. In addition, we generated preliminary data showing an impairment of autophagy in chondrocyte models of Achondroplasia (ACH) and Thanathoporic dysplasia, two skeletal disorders caused by mutations in FGFR3. We propose to study the role of autophagy in the pathogenesis of FGFR3-related dwarfisms and explore the pharmacological modulation of autophagy as new therapeutic approach for achondroplasia. This application, which combines cell biology, mouse genetics and pharmacological approaches, has the potential to shed light on new mechanisms involved in organismal development and homeostasis, which could be targeted to treat bone and cartilage diseases.

Keywords: autophagy,lysosome,fibroblast growth factors,bone,cartilage