Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Just because we can, should we? An anthropological perspective on the initiation of technology dependence to sustain a child’s life (TechChild)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Ireland
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2025-01-31
Duration (months): 72.0
Total project cost (EUR): 1464101.0
EU funding (EUR): 507185.69
Participants: 2
Project status: SIGNED

There is an increasing number of children with complex healthcare needs who require continuous technological support to sustain their lives. This technology dependence is initiated in an environment of medical interventionism, with potential for discrete discrimination. A scarcity of empirical data on the influences and interactions at the point of the initiation of technology dependence means that clinical, legal and ethical deliberations are driven more by opinion than empirical evidence. An evidence-based theoretical construct is required to articulate and contextualise the levers and penalties of the initiation of this technology. TechChild asks just because we can, should we? and how are the influences on the initiation of technology dependence understood in contrasting health, legal, and socio-political systems? Serendipitous findings from my research indicates parental concern regarding an absence of transparency, and parents are questioning patterns of family characteristics, when technology dependence is initiated. TechChild will be a step change in how we understand the coexistence of humans with an increasing availability of technological augmentations. This is urgent in a society where this debate predominantly happens in the public domain with limited opportunity for healthcare professionals to offer their perspective. TechChild will revolutionise how we conceive access to care and offers a research horizon that questions cultural relativism in a cyborg era. This is a scholarly ambitious project involving Paediatric Intensive Care Units in four international sites using a Bayesian framework to elicit the probability of factors likely to influence the initiation of technology dependence, leading to the development of a theory of technology initiation. This ground-breaking exploration will inform technology initiation across the lifespan with implications for healthcare, bioethics, education, parenting, policy making, and legal.

Keywords: child health,critical care,mixed methods,multi disciplinary,technology dependence,access to care
High-frequency printed and direct-written Organic-hybrid Integrated Circuits (HEROIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Italy
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2020-03-31
Duration (months): 60.0
Total project cost (EUR): 1608125.0
EU funding (EUR): 1608125.0
Participants: 1
Project status: CLOSED

The HEROIC project aims at filling the gap between the currently low operation frequencies of printed, organic flexible electronics and the high-frequency regime, by demonstrating polymer-based field-effect transistors with maximum operation frequencies of 1 GHz and complementary integrated logic circuits switching in the 10-100 MHz range, fabricated by means of printing and direct-writing scalable processes in order to retain low temperature manufacturability of cost-effective large area electronics on plastic. The recent development of semiconducting polymers with mobilities in the range of 1 to 10 cm^2/Vs, and even higher in the case of aligned films, suggests that suitably downscaled printed polymer transistors with operation frequencies in the GHz regime, at least three orders of magnitude higher than current printed polymer devices, are achievable, by addressing in a holistic approach the specific challenges set in the HEROIC trans-disciplinary research programme: (i)development of scalable high resolution processes for the patterning of functional inks, where printing will be combined with direct-writing techniques such as fs-laser machining, both in an additive and subtractive approach; (ii)development of printable nanoscale hybrid dielectrics with high specific capacitance, where low-k polymer buffer materials will be combined with solution processable high-k dielectrics, such as insulating metal oxides; (iii)improvement of the control of charge injection and transport in printed polymer and hybrid semiconductors, where high-mobility 1-D and 2-D structures are included in polymer films; (iv)development of advanced printed and direct-written transistors architectures with low parasitic capacitances for high-speed operation. HEROIC will radically advance and expand the applicability of polymer-based printed electronics, thus making it suitable for next generation portable and wearable short-range wireless communicating devices with low power consumption.

Keywords: printed electronics,flexible electronics,large area electronics
Genotoxicity prediction by means of QSAR methods for regulatory purposes (GenoQSAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

The concern to protect human health and the environment has prompted significant changes in EU regulation on chemical substances. The European Chemicals Agency (ECHA) plays the role in implementing the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) legislation, that requires industry to evaluate the toxicity of chemical substances that are in use but have never been subjected to regulatory testing. REACH regulation has also raised strong criticism and concern from society and industrials because of ethical and economic reasons. The toxicity evaluation of chemicals requires costly, time-consuming and ethically questionable animal experiments. As consequence, this European regulation promotes scientific innovation and encourages the use of results generated by alternative methods, including especially non-testing methods (NTMs), also referred to as in silico tools. Among them, “Quantitative Structure-Activity Relationships” (QSAR) methods are one of the most recognized machine learning methods in drug design, toxicology, industrial and environmental chemistry. Nowadays, they can be included in integrated testing strategies (ITS), to provide information for hazard and risk assessment, classification and labelling. We propose the development of an ensemble of QSAR predictive models for several parameters related with the different kinds of genotoxicity damage. These chemoinformatic will be implemented on a proprietary computational technological platform. Particular attention will be also payed to the generation of models for nanomaterials, taking into account their high and growing impact nowadays on industry in general.The QSAR models and integration algorithms will be characterized by their reliability, and will be developed according to the rules set out by the OECD, therefore guaranteeing their validity in REACH.

Keywords: genotoxicity,quantitative structure activity relationships qsar,eu reach regulation,artificial,intelligence,machine learning,computational toxicology,chemoinformatics,animal tests reduction
Bi-Isotope 0n2b Next Generation Observatory (BINGO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-10-01
End date: 2026-03-31
Duration (months): 66.0
Total project cost (EUR): 2420370.0
EU funding (EUR): 2420370.0
Participants: 1
Project status: SIGNED

BINGO will set the grounds for a large-scale bolometric experiment searching for neutrinoless double beta decay with a background index of about 10-5 counts/(keV kg y) and with very high energy resolution – of the order of 1.5‰ – in the region of interest. These features will enable a search for lepton number violation with unprecedented sensitivity. The BINGO approach can lead to the demonstration of the Majorana nature of neutrino even in the unfavourable case of direct ordering of neutrino masses. BINGO is based on luminescent bolometers for the rejection of the dominant alpha surface background. It will focus on two extremely promising isotopes – 100Mo and 130Te – that have complementary merits and deserve to be both considered for future large-scale searches. The project will bring three original ingredients to the well-established technology of hybrid heat-light bolometers: i) the light-detector sensitivity will be increased by an order of magnitude thanks to Neganov-Luke amplification; (ii) a revolutionary detector assembly will reduce the total surface radioactivity contribution by at least one order of magnitude; (iii) for the first time in an array of macrobolometers, an internal active shield, based on ultrapure ZnWO4 scintillators with bolometric light readout, will suppress the external gamma background. These challenging technologies will be extensively tested in a two-isotope demonstrator, dubbed MINI‑BINGO, which will be located in an underground laboratory in a dedicated cryogenic infrastructure built with ERC funds. The BINGO approach can be implemented in the next-generation search CUPID, a proposed follow up of the CUORE experiment. BINGO can improve dramatically the sensitivity of CUPID, using two isotopes at the same time and providing the demonstration of its background goal. Subsequently, the intrinsic modularity of the bolometric technique would make sensible to proceed to further expansions, capable of penetrating the direct-ordering band.

Keywords: neutrinoless double beta decay,low temperature detectors
Dark Estuaries: Mapping coastal aquifer biodiversity in a changing world (DARKEST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-12-01
End date: 2023-11-30
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: SIGNED

Subterranean estuaries extend inland into coastal aquifers inhabited by a surprising diversity of subterranean animals with peculiar ecological and evolutionary features. How complex ecosystems thrive in this globally distributed habitat in different hydrological and geological settings is poorly understood. This study aims to integrate a novel global database of subterranean fauna with existing geochemical data and high-resolution hydrogeology maps of the world’s aquifers, using modern statistical and modelling methods, to achieve an integrated understanding of the drivers of biodiversity in coastal aquifers and their response to global environmental change. Indeed, coastal aquifers connect the world’s oceanic and hydrologic ecosystems and provide water source for more than one billion people in coastal regions, but these habitats are among those most prone to the long-term effects of climate change and human population growth. Therefore, expected outcomes of the study will contribute to the increasing efforts to discover, describe, and sustain groundwater-dependent ecosystems and to identify biological communities that could serve as indicators of the health of groundwater resources. To achieve these goals, a holistic approach is proposed that bridges scientific disciplines across ecology and geosciences. The project also targets to build the foundation for my long-term plans, that is, to reintegrate in Europe and establish myself as a leading expert in the emerging field of Earth System Ecology. Ensuring success, I will be supervised by host Diego Fontaneto, an expert in ecology, evolution, and large-scale patterns of biodiversity of microscopic animals at the Water Research Institute of CNR in Italy. Moreover, I will benefit from interactions with secondment-host Nils Moosdorf, who has expertise in aquifer hydrogeology, data-driven geoscience, and mega-scale hydrological modelling, at the Leibniz Centre for Tropical Marine Research in Germany.

Keywords: functional diversity,groundwater,coastal aquifer,subterranean estuary,anchialine,hydrogeology,community ecology,macro ecology,modelling
Evolution of plant PWO proteins and their function: a synthetic biology approach (EvoPWO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 156980.64
EU funding (EUR): 156980.64
Participants: 1
Project status: CLOSED

The Polycomb Group (PcG) proteins ensure the accuracy of developmental processes and maintain cellular identities in both plants and animals. Among the PcG proteins, Polycomb Repressive Complex 2 (PRC2) establishes the repressive state of targeted genes by introducing the H3K27me3 epigenetic mark. Recently, a novel PWWP DOMAIN INTERACTOR OF POLYCOMBS 1 (PWO1) protein has been identified as a recruiter and regulator of PRC2. PWO1 may also act as a mediator of PRC2 repression at the nuclear periphery (NP). Even though PRC2 orthologues are highly conserved from unicellular algae to modern plants, the PWO-like proteins do not seem to follow the same evolutionary pattern as they exclusively arise at a specific time in plant evolution, coinciding with the colonization of land and emergence of vascular systems. This poses the question of how PWO-like proteins shaped the evolution of the PcG pathway and contributed to plant evolution in a developmental context. To answer this, I plan to apply a synthetic biology approach with the aim to assess the impact of PWO-like proteins on PWO-less species, particularly to understand whether PWOs can reprogram PRC2 epigenetic activities. Furthermore, the inspection of ancestral PWOs functions in modern plants will provide essential information regarding the conservation of their activity, for instance, the PWO-mediated link of chromatin repression to the NP across the species. Lastly, the exploration of unknown interacting partners of PWO-like proteins in both ancestral and modern plants will give insights for the conservation and functions of the PWO-related protein network in PRC2 regulation. Altogether, this project will shed light on the potential mechanisms underlying the enrolment of PWOs function in developmental epigenetics during land plant evolution. The acquired expertise through the proposed project will be crucial for me to work as an independent researcher in the area of plant epigenetics and evolutionary biology.

Keywords: epigenetic modification,pcg pathway,prc2,pwo1,crwn1,h3k27me3,evolution,plant development,regulation of gene expression
Tipping Points in the Earth System (TiPES)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Italy,Switzerland,Norway,Belgium,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal,Denmark
Call: Addressing knowledge gaps in climate science, in support of IPCC reports (H2020-LC-CLA-2018-2, 2018)
Start date: 2019-09-01
End date: 2024-02-29
Duration (months): 54.0
Total project cost (EUR): 8561238.75
EU funding (EUR): 8561238.75
Participants: 20
Project status: SIGNED

There is rising concern that several subsystems of the Earth may respond highly nonlinearly at critical future levels of anthropogenic forcing; these levels have recently been associated with tipping points (TPs). It is paramount to identify safe operating spaces for humanity and the planet in terms of these critical forcing levels, in order to prevent harmful transitions to alternative, undesirable states of the Earth system. The mechanisms leading to such abrupt transitions are only partly understood, and further research in this regard is urgently needed. State-of-art Earth System Models appear to respond too smoothly at TPs and have difficulties in simulating abrupt transitions that occurred in the planet’s history. TiPES will address these problems from several angles: 1. The project will identify subsystems that may exhibit abrupt transitions, and couplings between them, by focussing on paleoclimatic records and abrupt transitions therein. Novel methods to detect Early Warning Signals of forthcoming TPs, and to make skilful predictions on their basis, will be developed. 2. The potential shortcomings of models in representing TPs will be evaluated; in particular, TiPES will investigate how Bayesian calibration techniques can help enable these models to simulate past abrupt transitions. 3. TiPES will develop a generalized theory of climate sensitivity that accounts for the presence of TPs and feedbacks across various time scales. 4. To define safe operating spaces. TiPES will focus on dynamical system theory and on global stability notions for non-autonomous systems in order to estimate the stability of desirable states. 5. The results obtained by the project will be communicated to policy makers in a manner that facilitates decisions and their implementation. TiPES will develop formal approaches to define the socioeconomic risks of crossing TPs, and to derive decision strategies to keep anthropogenic forcing below levels where abrupt transitions may occur.

Keywords: bayesian model calibration,bifurcation theory,critical transitions,decision theory,non autonomous systems,paleoclimate,safe operating spaces,tipping points,uncertainty quantification
Network for the exchange and transfer of innovative knowledge between European wine-growing regions to increase the productivity and sustainability of the sector (WINETWORK)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Coordination and support actions
Countries involved: Spain,Italy,Germany,Spain,Hungary,Croatia,France,France,France,Portugal
Call: Closing the research and innovation divide: the crucial role of innovation support services and knowledge exchange (H2020-ISIB-2014-1, 2014)
Start date: 2015-04-01
End date: 2017-09-30
Duration (months): 30.0
Total project cost (EUR): 1999471.75
EU funding (EUR): 1999221.75
Participants: 13
Project status: CLOSED

Building on a methodology for innovation-driven research previously developed and tested, the WINETWORK project has the ambition to stimulate collaborative innovation in the wine sector. The project will implement a methodology that has been successful in promoting demand-driven innovations in previous regional and European projects. This approach is mainly based on the interactions between a network of facilitator agents, several regional technical working groups and one European scientific working group. A participatory approach is used to translate results from science and practical knowledge into technical datasheets that are used to prepare materials adapted to end-users. A bottom-up approach is also used to identify a demand-driven innovation agenda. In the WINETWORK project, the approach will be implemented in ten regions from seven countries representing more than 90% of the EU wine production. The main topic addressed in the network concern the control and the fight against diseases that jeopardise the future production potential of the EU (Grapevine Trunk Diseases and Flavescence Dorée). As they represent a threat for the economic viability of the entire sector, these topics have been previously identified as a priority by winegrowers, scientists and decision-makers. As many winegrowers are testing innovative and sustainable approaches to fight these diseases, it is very beneficial to capture these ideas and to share them between EU countries. Innovative practices will be synthesized, tailored and translated to become fully accessible to innovation support services and to winegrowers. The project will then deliver a vast reservoir of existing scientific and practical knowledge related to sustainable vineyard management. It will also provide a methodology that will support all agriculture sectors to enhance innovation-driven research. WINETWORK involves 11 partners of excellence representing the entire innovation chain, from science to farmers.

Keywords: viticulture,plant protection