Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
KlotoDx A quick and cost-effective near-patient tool to identify sepsis-related bacteria and antibiotic resistances (KlotoDx)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2018-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Sepsis is a common disease caused mostly by bacteria that affects about 30 M people each year worldwide. If not diagnosed on time and treated appropriately, it may be lethal in 30% of cases and the cost for the healthcare system if not detected within the first 24 hours can rise dramatically. Current diagnostic techniques used to detect bacteria in patients’ blood, and identify their antimicrobial resistances, are still based on blood culture which takes more than 1 day and has a very limited detection efficiency. Moirai Biodesign is currently engineering a whole new generation of RNA-based diagnostics using both our in-house and cutting-edge artificial intelligence algorithms to detect ribosomal RNA from bacterial agents and expressed bacterial genes associated to common antibiotic resistances and a patient’s blood sample. Our platform is a near-patient, fast, efficient and cost-effective solution for the early detection and characterization of sepsis-related bacteria which will improve patient’s treatment, avoid broad-spectrum antibiotics’ side-effects and dramatically reduce death rates. Our technology has been preliminary validated for the diagnosis of Acute Promyelocytic Leukemia (APL) and KlotoDx’s main goal is to further adapt, validate and commercialize our disruptive diagnosis device for the identification of sepsis-causing bacteria and their antibiotic resistance genes. To achieve it and place our disruptive near-patient solution in the healthcare market, we envision a total investment of around €2.3 M and we plan to reach the 70% (around €1.6M) by applying for a Phase 2 within the H2020 SME-Instrument programme, once we perform the feasibility study during Phase 1. The increasing need for early sepsis diagnosis aand its characterization in terms of antibiotic resistance boosts KlotoDx’s opportunity to enter the primary care segment in a very disruptive manner.

Keywords: plug and play rna,sepsis,bacteria,antibiotic resistance,diagnosis,syntethic rna,moirai biodesign
Marriage, Migration and Sexuality: African Migrants in Interracial Same-sex Partnerships (MARMIGSEX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-08-01
End date: 2024-07-31
Duration (months): 36.0
Total project cost (EUR): 271052.16
EU funding (EUR): 271052.16
Participants: 2
Project status: SIGNED

In an interconnected world, the introduction of same-sex marriage in many countries has also affected the lives of LGBTI persons outside their territories, even where homosexuality is illegal. Marrying a (same-sex) citizen of these countries entails family migration rights for the non-citizen spouse. The project Marriage, Migration and Sexuality: African Migrants in Interracial Same-sex Partnerships (MARMIGSEX) investigates how same-sex marriage became a new (formal) migration channel for queer Africans and particularly examines same-sex marriage migration from sub-Saharan Africa (Kenya, Ghana) to countries of the Global North (USA, Netherlands). MARMIGSEX is an interdisciplinary research project that offers a novel approach to the study of marriage migration, transnationalism and interracial relations. First, it overcomes the heterosexual bias in the study of marriage migration and focuses on the international mobility of Africans through same-sex marriage. It examines the mobility options and paths of cross-border same-sex couples and whether and how they managed to live together before and after the introduction of same-sex marriage. Second, the project breaks from the convention of limiting study to the perspective of migrant destination countries, by emphasizing the perspective of origin countries. It explores whether and how same-sex marriage migration enables African men and women to achieve social mobility and gain appreciation and respect in Africa. Third, it questions the assumption in migrant assimilation theory that “mixed couples” are indicators of integration and a proof that ethnic and racial boundaries become less important (at least for the partners in these relationships). Hence it investigates the process of racialization of African migrants’ sexuality and how racialized sexuality becomes a resource of exchange value for African men and women.

Keywords: same sex marriage,cross border marriage,marriage migration
Real-time Earthquake Risk Reduction for a Resilient Europe (RISE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Protection of the environment, sustainable management of natural resources, water , biodiversity and ecosystems
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Italy,Italy,Israel,Italy,Iceland,Germany,Italy,Italy,Türkiye,New Zealand,Switzerland,France,France,France,France,United States,Netherlands,United Kingdom,United Kingdom,United Kingdom,Japan,Mexico,United Kingdom
Call: Towards operational forecasting of earthquakes and early warning capacity for more resilient societies (H2020-SC5-2018-2, 2018)
Start date: 2019-09-01
End date: 2023-05-31
Duration (months): 45.0
Total project cost (EUR): 8360000.0
EU funding (EUR): 8000000.0
Participants: 29
Project status: SIGNED

The key concept and vision of RISE is to promote a paradigm shift in how earthquake risk is perceived and managed. We believe that by taking advantage of advances in scientific understanding, and dramatically changing technological capabilities, earthquake hazard and risk will soon be appreciated not as a constant in time, but as an evolving, integrated and dynamic risk. In our concept, dynamic risk depends on location, changing with soil conditions, topography, structural type, occupancy and use and even location within a structure. However, dynamic risk also includes changes with time, for example increasing when a seismic sequence is active nearby and due to an improved dynamic geophysical understanding of faulting and earthquake processes. RISE proposes a series of coordinated activities in the domains of Operational Earthquake Forecasting, Earthquake Early Warning, Rapid Loss Assessment and Recovery and Rebuilding Efforts. Our approach is multi-disciplinary, involving earth-scientists, engineering-scientists, computer scientists, and social scientists. It is multi-scale in space and time, and addresses these scales in a highly systemic and consistent way. RISE joins with EPOS Integrated Core Service and several of the Thematic Core Services (TCS), with ARISTOTLE and the Copernicus Emergency Management Service. Integration will also include responsible national agencies in Italy, Turkey, Iceland, Israel and Switzerland and with selected industry partners. To maximise the impact of RISE, we have assembled an interdisciplinary team of truly outstanding researchers and practitioners, 37 PIs from 24 institutions (including 5 contributing partners from outside of Europe), in 13 countries, with documented experience on the topics of the project developed in previous FP6, FP7, and H2020 projects.

Keywords: operational earthquake forecasting,earthquake early warning,rapid impact assessment
MUltimetallic SYstems for C-H Activation processes (MUSYCA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2022-07-31
Duration (months): 36.0
Total project cost (EUR): 245732.16
EU funding (EUR): 245732.16
Participants: 2
Project status: CLOSED

MUSYCA - Multimetallic Systems for C-H Activation processes - is a project designed to obtain a better understanding of the key factors governing C-H activation phenomena in multinuclear copper-based cores present in the most efficient frameworks such as enzymes or zeolites like methane monooxygenases (MMOs) or Cu-ZSM-5, respectively. One of the main goals of the project is to obtain complexes containing Cu2O entities, which have not yet been interrogated and are reactive enough to oxidize C-H bonds. These will be employed in the stoichiometric and catalytic transformation of hydrocarbon bonds of numerous substrates, from easily convertible to extremely challenging ones, being methane the stretch goal. The reactivity patterns and the corresponding mechanisms underlying the formation of Cu-O fragments as well as those involving the formation of C-O bonds will be studied by using a wide variety of analytical techniques. To this end, robust 2,7-substituted [1,8]naphthyridine scaffolds will be employed as dinucleating ligands, since they resemble the environment surrounding dinuclear active sites in natural enzymes and they facilitate a close interaction between the metals, at the same time that the chelating groups in positions 2 and 7 help to stabilize the resulting complexes. These ligands will also be employed in the other major target of the project, which consists of the development of dinuclear Pt-Cu compounds so as to evaluate the metal cooperativity in a modified Shilov system for C-H activation. Only a few studies have been carried out on the role of copper in the Shilov-type C-H functionalization reaction, showing its great potential for improving the catalytic performance of the active species involved in the process. However, the role of Pt as active catalyst and Cu as oxidant in the same complex has never been investigated, and the aforementioned frameworks developed in the labs of Prof. Tilley are ideal for this purpose.

Keywords: organometallic homobimetallic and heterobimetallic complexes,c h activation,copper chemistry,dioxygen activation,enzyme mimicking,mechanistic studies,synthesis and characterization
Morphogenesis and Molecular Regulation of Colour Patterning in Birds (COLOUR PATTERN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-04-30
Duration (months): 60.0
Total project cost (EUR): 1483143.75
EU funding (EUR): 1483143.75
Participants: 2
Project status: CLOSED

Animals display a tremendous diversity of patterns ‒from the colourful designs that adorn their body to repeated segmented appendages. Natural patterns result from the formation of discrete domains within developing tissues through the integration of positional cues by cells that consequently adopt specific fates and produce spatial heterogeneity. How can such developmental processes underlie the apparent complexity and diversity of natural patterns? We propose to address this long-standing question with an innovative experimental design: we will make use of natural variation as a powerful tool to facilitate the identification of patterning molecules and morphogenetic events. We will study colour pattern, a crucial adaptive trait that varies extensively in nature, from large colour domains to periodic designs. In amniotes, colour pattern is formed by spatial differences in the distribution of pigment cells and integumentary appendages. While the pigmentation system has been well characterized, the mechanisms governing the formation of compartments in the skin of wild animals have remained unclear, largely because laboratory models do not display ecologically-relevant colour patterns. We will use a combination of forward genetics, developmental biology, modelling, and imaging to study natural variation in the large colour domains of Estrildid finches and the periodic stripes of Galliform birds. For both phenotypes, we will characterize the organization of the embryonic skin and the mode of patterning (i.e., instructional patterning via external cues vs locally-occurring self-organization) underlying their formation, and identify the molecular factors and developmental processes contributing to their variation. Results from these studies will elucidate the biochemical events and tissue rearrangements orchestrating colour patterning in development and shed light on how these processes shape natural variation in this trait‒ and more generally, in natural patterns.
New Science and Technology of Artificial Layered Structures and Devices (MATTERDESIGN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2022-04-30
Duration (months): 72.0
Total project cost (EUR): 1456252.5
EU funding (EUR): 1456252.5
Participants: 2
Project status: CLOSED

The extensive and growing library of layered crystals opens up the exciting possibility of exfoliating them into single atomic layers and stacking these atomic layers back together in new sequences to fabricate a new class of artificial van der Waals solids, with novel properties and functionalities. The principal objectives of this proposal are to study the fundamental physics and chemistry of novel materials, structures and devices synthesised by assembling different two-dimensional (2D) crystals and to exploit their unique properties for diverse applications. The applicant primarily aims to explore the new science and technology of extremely narrow 2D capillaries synthesised by assembling various precisely patterned 2D crystals. Molecular transport through nano-capillaries is highly important due to its applicability in filtration and separation technology and also because of the unusual fundamental behaviour arising at the molecular scale. In this proposal, the applicant plans to study the behaviour of molecules, atoms and ions confined in the ultra-narrow 2D channels and explore the use of these devices for nanofluidic applications. Furthermore, the potential of these 2D channels for the synthesis of artificial structures by encapsulating various materials inside the channels will be investigated. The applicant plans to use a variety of techniques, such as chemical exfoliation and mechanical exfoliation, together with already established layer-by-layer coating or multiple transfer techniques, to produce novel materials and devices. The applicant will also investigate the potential of these novel layered materials for the fabrication of novel superconductors by intercalating them with various elements. The urge in pursuing this project relies on the fact that many intercalated graphite and other layered compounds are superconducting. The above research directions should create a solid basis for a world-leading research group led by the applicant.

Keywords: two dimensional materials,layered materials,graphene,membranes,nanofluidics
Fulfilling Paul Ehrlich’s Dream: therapeutics with activity on demand (ZAUBERKUGEL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

Paul Ehrlich was the first scientist to postulate that if a compound could be made that selectively targeted disease-causing cells, then this agent could be used for the delivery of a toxin, which would enable a pharmacotherapy of unprecedented potency and selectivity. With this procedure, a "magic bullet" (Zauberkugel, his term for an ideal therapeutic agent) would be created, that killed diseased cells while sparing normal tissues. The concept of a "magic bullet" was to some extent realized by the invention of monoclonal antibodies, as these molecules provide a very specific binding affinity to their cognate target. However, monoclonal antibodies used as single agents are typically not able to induce cures for cancer or chronic inflammatory diseases. More recently, intense academic and industrial research activities have aimed at “arming” monoclonal antibodies with drugs or cytokines, in order to preferentially deliver these therapeutic payloads to the site of disease. Unfortunately, in most cases, "armed" antibody products still cause unacceptable toxicities, which prevent escalation to potentially curative dose regimens. In this Project, I outline a therapeutic strategy, which relies on the use of extremely specific tumor targeting agents, for the selective delivery of payloads, which can be conditionally activated at the site of disease. Methodologies for the conditional generation of active payloads include the stepwise non-covalent assembly of cytokines and the controlled release of cytotoxic drugs at suitable time points after injection, when the concentration of therapeutic agent in normal organs is acceptably low. Response to therapy will be profiled using innovative proteomic methodologies, based on HLA-peptidome analysis. Pharmaceutical agents with “activity on demand” hold a considerable potential not only for the therapy of cancer, but also for the treatment of other serious diseases, including certain highly debilitating chronic inflammatory condition

Keywords: therapeutic antibodies,immunocytokines,antibody drug conjugates,small molecule drug conjugates,vascular tumor targeting,cancer therapy,protein engineering
In-Memory Computing and Artificial Intelligence Platform for Building Next Generation Enterprise Software (Starcounter)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Sweden
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 3122872.5
EU funding (EUR): 2186010.75
Participants: 1
Project status: CLOSED

Gartner predicts that in 5 years there will be 10 times more entreprise software applications (bizapps) than today. 75% of these new bizapps will be built, not bought from the shelf. This confirms huge demand for developing new software. At the same time the cost of IT has already become prohibitive. Companies cannot afford satisfying their appetites for new software under the current software production, delivery and maintenance model. Starcounter proposes a fundamentally new approach and technology for developing and deploying enterprise software. Starcounter combines in-memory computing and an application server with an Artificial Intelligence engine for app-to-app interoperation and a transactional database of unlimited scalability. It is a complete application development, deployment, maintenance, scale-up and re-use platform, primarily designed for Independent Software Vendors (ISVs). With Starcounter the code base of any major complex enterprise software system can be reduced by ~90%. Likewise it allows to drastically cut the demand for computing and storage resources. In one of our first deployments Starcounter allowed to cut the requirements of a large and complex ERP system from 100 machines to just 3. The second key feature of Starcounter is that it allows independently developed applications to work seamlessly together out-of-the-box. Integration can become deep, fast, synchronous and practically infinitely scalable. Sophisticated and complex systems can thus be developed by combining bizapps like Lego bricks, without programming, APIs, or glue code. New bizapps can be developed in days, not months, and integrated in minutes instead of weeks. The current version of Starcounter more than 40 billion transactions monthly at more than 1000 enterprises using bizapps developed by our early adopters: ISVs from Northern Europe. Starcounter is based on our original software engineering concepts protected with a portfolio of 14 patents.

Keywords: it infrastructure,enterprise software,dbms,apps,mvvm,ontology