Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
An integrated approach to restore tolerance in autoimmune disease (TOLERATE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium,Netherlands,Hungary,Ireland,Germany,Spain,Italy,France,Denmark
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 2262241.77
EU funding (EUR): 2109650.4
Participants: 21
Project status: SIGNED

The TOLERATE training network aims at training DC’s to acquire the skills to develop different innovative strategies to treat autoimmune diseases, to identify the most promising strategies or a combination of strategies, to setup clinical trials and to develop a roadmap to bring a novel therapeutic agent to the market. This all will be done in a highly interdisciplinary and intersectoral environment. Interdisciplinarity allows to introduce innovative tolerogenic therapies developed for cancer, Chimer Antigen Receptor (CAR)-T cell therapies, into the world of autoimmune disease and to apply nanotechnology and protein-engineered tolerogenic vaccines to re-establish immune tolerance in autoimmune disease. Both the presence of academia and industry provides a platform for in-depth preclinical studies and a realistic possibility for future commercialization of the novel therapies. Clinicians in the consortium with expertise in setting-up and running clinical trials for novel drugs assure that developed novel therapies in TOLERATE will find their way to the clinic in the future. Developing novel therapies for autoimmune diseases goes close together with a thorough knowledge on the long-term consequences of living with an autoimmune disease. Since many autoimmune diseases are rare diseases, setting up international uniform databases and biobanks is crucial to understand the long-term pathophysiology of the disease and to guarantee optimal use of (novel) therapies. TOLERATE will train 8 DCs who will hence has the expertise and skills to work in and setup interdisciplinary and intersectoral projects. The ground-breaking training programme will provide the DC’s with a unique clinical training. Additional training in ethical, regulatory and legal aspects together with a training in innovation management of therapeutics and diagnostics for autoimmune diseases will prepare the DCs for the European job market.

Keywords: autoimmune disease tolerogenic vaccine t cell receptor engineered tregs car t cell therapy immune mediated thrombotic thrombocytopenic purpura clearance
INtegrated Short-term PallIative REhabilitation to improve quality of life and equitable care access in incurable cancer (INSPIRE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: France,United Kingdom,Belgium,Italy,Norway,Denmark,Czechia
Call: Improved supportive, palliative, survivorship and end-of-life care of cancer patients (HORIZON-HLTH-2021-DISEASE-04, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 2725301.0
EU funding (EUR): 2725301.0
Participants: 14
Project status: SIGNED

Disability related to incurable cancer affects over a million Europeans each year. Our objective is to test the clinical and cost effectiveness of an integrated short-term palliative rehabilitation intervention, to improve function and quality of life in people affected by incurable cancer. At the core of INSPIRE is a multinational randomised controlled trial across six European countries. We will recruit 340 participants to assess the clinical and cost-effectiveness of palliative rehabilitation on quality of life, disability, symptom burden and goal attainment in people with incurable cancer. If positive, the trial could result in a scalable and equitable intervention that improves function and quality of life in people with incurable cancer, and reduces the burden of care for their families. The intervention can be adapted and integrated into different health systems using existing staff and services, with little or no additional cost. To support our ambition to make palliative rehabilitation part of routine care for people with incurable cancer we also conduct: - comparative analysis of health services to understand current integration of rehabilitation across oncology and palliative care services; - mixed-method evaluations of equity and inclusivity, processes and implementation for the intervention, at patient, health service and health system levels; - evidence synthesis and a Delphi consensus on indicators, core interventions, outcomes, and integration methods, to develop a framework for palliative rehabilitation practice and policy. The INSPIRE consortium brings together leaders in palliative care, oncology and rehabilitation from Nordic, Southern, Northern and Central European countries, with complementary expertise in health services research, trials of complex interventions, mixed method evaluations, statistics and economics. We are partnering with European civil society organisations to ensure citizen engagement and dissemination at the highest level.

Keywords: rehabilitation,palliative,quality of life,symptom management
Cold Atom Rubidium Interferometer in Orbit for Quantum Accelerometry – Phase B (CARIOQA-PHB)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: France,Germany,Italy,Spain,Greece
Call: Quantum Space Gravimetry Phase-B study & Technology Maturation (HORIZON-CL4-2024-SPACE-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 14412735.39
EU funding (EUR): 14199370.14
Participants: 14
Project status: SIGNED

The overarching goal of CARIOQA-PHB is to establish a preliminary definition of the concept chosen for the Quantum Space Gravimetry Pathfinder Mission called CARIOQA. Indeed, the emergence of quantum sensors offers an opportunity to provide new applications for climate sciences through the improvement of space gravimetry performance. Hence, the mastery of this technology in space is one of the major environmental, technological and strategic challenges of the decade. As the second step of the CARIOQA programme, the main objectives of CARIOQA-PHB are: 1. To establish the preliminary design and technical solutions answering to the project and system requirements of the Quantum Space Gravimetry Pathfinder Mission, in agreement with ECSS-M-ST-10C. Complementary EU industrial partners will conduct the design phase while excellent institutes will bring their quantum expertise to guarantee the mission performance. This study will confirm the feasibility of each component of the system, including space and ground segment. 2. To establish a maturation plan for critical technologies and components necessary to the deployment of the mission within the decade. Pre-development activities will be conducted to bring identified critical technologies to TRL6. 3. To assess the readiness of the project and its maturity to enter into the following phases through a Preliminary Design Review concluding CARIOQA-PHB. CARIOQA-PHB brings together the main players of quantum sensors in Europe. It gathers unique skills among 14 partners from 5 EU Member States including 2 space agencies, 5 research organisations and 5 industries. Exploitation, communication and dissemination activities are handled by expert partners with a long track record of supporting EU funded projects. As a result, CARIOQA-PHB will secure the capacities for implementing quantum gravimeters/accelerometers in space within the EU, contributing to the EU's strategic goal of non-dependence and autonomy.

Keywords: quantum sensor,cold atoms interferometer,bose einstein condensate,space,gravimetry,geodesy,quantum pathfinder mission preparation,phase b
Unleashing the predictive power of tidal disruption events (Unleash-TDEs)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 1499853.0
EU funding (EUR): 1499853.0
Participants: 1
Project status: SIGNED

Tidal disruption events (TDEs) have been known for decades as unique probes of otherwise quiescent supermassive black holes and their environment, in a mass range inaccessible by any other techniques. However, fulfilling this potential has so far been hindered by a crucial lack of understanding of the physics causing the emission. My program will solve this theoretical bottleneck and unleash the predictive power of TDEs at the dawn of an observational golden era provided by the Rubin Observatory. A TDE occurs when a star is disrupted by a black hole, after which the stellar debris fuels the compact object, generating the detectable signal. While characterizing this emission has been prevented by the impossibility of simulating the entire gas evolution, I am pioneering a new computational approach that solves this long-standing impediment by dividing the evolution into interconnected phases. Relying on this technique, I will deliver the first paradigm for the TDE emission based on first-principles simulations. Using this new knowledge, I will build theoretical lightcurves that directly depend on astrophysical system parameters, namely the black hole and stellar properties, and develop the first physically sound analysis toolkit for detected TDEs, which statistically compares these lightcurves to observed ones to infer system parameters. Applying this toolkit to the wealth of upcoming TDE detections, I will shed new light on some of the most pressing mysteries in astrophysics, including the formation and growth of supermassive black holes, the properties and interactions between the stars orbiting them, and the processes leading to relativistic jets and neutrino production. My ambitious research program is designed to capitalize on the observational revolution brought about by the Rubin Observatory, setting the foundations for TDE science in the decade to come with far-reaching implications across fields from galaxy evolution to high-energy astrophysics.

Keywords: tidal disruption events,supermassive black holes,transient astrophysics,numerical simulations,hydrodynamics
ENFIELD: European Lighthouse to Manifest Trustworthy and Green AI (ENFIELD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Countries involved: Norway,Portugal,France,Sweden,Hungary,Austria,Denmark,Netherlands,Greece,Italy,Germany,Estonia,Slovenia,Spain,Finland,Cyprus,United Kingdom,Romania
Call: European Network of AI Excellence Centres: Expanding the European AI lighthouse (RIA) (HORIZON-CL4-2022-HUMAN-02, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 11262750.0
EU funding (EUR): 11262750.0
Participants: 32
Project status: SIGNED

ENFIELD will create a unique European Centre of Excellence that excels the fundamental research in the scientific pillars of Adaptive, Green, Human-Centric, and Trustworthy AI that are new, strategic and of paramount importance to successful AI development, deployment, and acceptance in Europe and will further advance the research within verticals of healthcare, energy, manufacturing and space by attracting the best talents, technologies and resources from world-class research and industry players in Europe and by carrying out top-level research activities in synchronisation with industry challenges to reinforce a competitive EU position in AI and create significant socio-economic impact for the benefit of European citizens and businesses. ENFIELD will develop, maintain, scale-up and sustain a vibrant European network on AI composed of 30 consortium members from 18 countries, including top-level education and research organisations, large scale businesses, SMEs, and public sector representatives jointly addressing critical issues of research and innovation frontiers in this new topic of the European AI Lighthouse. ENFIELD will provide high impact outputs such as >75 unique AI solutions (algorithms, methods, simulations, services, data sets and prototypes), 180 scientific high-impact publications and 200 peer-reviewed presentations, four strategic documents, namely the Common Research Roadmap and Vision, the dynamic Safety and Security Risk Assessment Framework, the White Paper and the Gender and Ethics Framework. The exchange and innovation schemes planned in Open Calls, which will grant financial support to >76 individual researchers and 18 small-scale projects, education, and training activities such as summer schools and hackathons, and a set of well-designed outreach methods and activities will further contribute to the ENFIELD community engagement, enlargement, and continuity.

Keywords: green ai,adaptive ai,humancentric ai,trustworthy ai,energy,healthcare,manufacturing,space,quintuple helix model,twin transition
Operando studies of praseodymium based mixed oxide supported metal catalysts for the direct conversion of methane to methanol: bridge the gap of model catalysis and ambient applications (PraMixCat)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-08-01
End date: 2025-10-31
Duration (months): 27.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 1
Project status: SIGNED

The direct conversion of methane to methanol (DCMM) has attracted strong interest due to its great potential use in the energy and chemicals sectors, at the same time diminishing the greenhouse effect. However, this process is challenging for heterogeneous catalysis due to the high energy required for cleaving the C−H bond in CH4, as wells as the facile over-oxidation of CH3OH to CO or CO2. Recent ultrahigh vacuum (UHV) studies indicate that metal-oxide surfaces/interfaces can facilitate DCMM with high selectivity at low temperature in a single batch mode. Inspired by the model studies, in this project we will synthesize a series of praseodymium mixed oxides supported Cu and Au catalysts (i.e. Cu-Au/Ce1-xPrxO2-δ, Cu-Au/Zr1-xPrxO2-δ) and explore its application for DCMM under ambient conditions. Major challenges in designing this system for DCMM is the identification of the active sites in the working state and correspondingly tailoring its properties, which can be overcome by using in situ/operando techniques and ‘defect engineering’. The catalytic performance will be investigated using both a batch (and flow) reactor and an operando spectroscopy cell. Near ambient pressure X-ray photoelectron spectroscopy (NAP-XPS) and X-ray absorption near edge structure spectroscopy (XANES) will be used to determine the electronic state of the metals. Structure, including defects, of catalysts will be investigated by in situ X-ray absorption spectroscopy (XAS), X-ray diffraction (XRD), Selected Area Electron Diffraction (SAED) and Raman scattering. The reaction mechanism will be investigated by concentration-modulation Fourier transform infrared (FTIR) spectroscopy and operando Raman scattering. This study will provide strongly validated mechanistic and structural conclusions for the future design and optimization of nanostructured DCMM catalysts and represent ground-breaking work at the intersection of surface science and applied catalysis.

Keywords: direct conversion of methane to methanol,gold catalysis,o vacancies,in situ operando,model catalysis,mixed oxides,uhv,defect engineering,nap xps,xas
Advanced Sterilization Capability with Low Environmental footprint for Patient Infection Optimized Safety (ASCLEPIOS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-12-01
End date: 2025-05-31
Duration (months): 18.0
Total project cost (EUR): 3570198.75
EU funding (EUR): 2499139.13
Participants: 1
Project status: SIGNED

MedTech industry is facing the emergence of innovative single-use and reusable medical devices [MD] with ever more complex forms and sensitive components in needs of optimal safety conditions of sterilization. However, hospitals face problems with chemicals, radiation, and limited sterilization options, leading to compromises in patient safety and potential device contamination [over 20% of endoscopes are tainted]. Similarly, MD manufacturers encounter technological, environmental and health obstacles, which can limit production capacity and endanger patients' lives. Regulatory and political pressures are growing to eliminate the use of ethylene oxide (EtO), and current technologies face challenges in capacity and compatibility with MD materials, reducing the resilience of production of MDs. In this context, AURORA has developed the first In Situ Cold [non-Thermal] Plasma Sterilization technology for MD that turns air gases into a plasma and doesn’t use any chemicals, radiations, nor leave any potentially harmful residue. This breakthrough process, able to destroy all biothreats, is designed to answer the needs of both hospitals and MD manufacturers in better safety standard for patient and staff, and environmental protection. ASCLEPIOS will materialize 12 years of R&D programs which aimed at validating the feasibility of its cold-plasma sterilization process and developing its efficacy on the full range of biothreats [spore, viruses, bacteria, biofilms] and while remaining compatible with fragile MDs, representing key assets towards unlocking early technical and economic barriers to commercial exploitation. While TRL6 has been successfully passed, the herein ASCLEPIOS proposal will allow reaching TRL9. This last step allows the technology to be deployed Europe- and US-wide, creating a strong economic activity, replacing current solutions and thus meeting social, health and environmental challenges and establishing a strong European leadership in this new field.

Keywords: low temperature plasma,hospital acquired diseases,chemical free sterilization,reusable medical devices,single use medical devices,endoscope contamination
Frustrated systems with low-dimensional magnetism for magnetic refrigeration and hydrogen liquefaction (FRUMALIQ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-03-31
Duration (months): 18.0
Total project cost (EUR): 130385.52
EU funding (EUR): 130385.52
Participants: 1
Project status: CLOSED

Carbon-free hydrogen represents one of the pillars of global energy transformation. However, higher efficiency within the hydrogen supply chain, including liquefaction, is the crucial prerequisite to reduce its cost and trigger its wider use. Magnetic refrigeration, which utilizes the magnetocaloric effect, promises to double the efficiency of hydrogen liquefaction compared to gas-compression cryocooling, but the technologies available at present mostly employ magnetocaloric materials containing strategically important rare-earth (RE) metals and expensive superconducting magnets. We propose to search for suitable RE-free materials within an emerging class of magnetocalorics based on frustrated magnets, which are especially suitable for cooling at cryogenic temperatures. According to theoretical predictions and pioneering studies, these materials offer high effectivity in permanent magnets, higher cooling rates, and a larger temperature span than non-frustrated systems. The RE-free frustrated magnetocalorics have been little prospected so far to achieve the limits of their efficiency. The project aims to (1) synthesize novel RE-free frustrated magnets with low-dimensional magnetic motifs and to enhance their magnetocaloric performance at cryogenic temperatures by suitable chemical modification, while (2) exploring correlations between the magnetocaloric effect, local atomic and magnetic structure, and magnetic fluctuations. The synthesis of novel compounds will be followed by magnetometry and calorimetry, while local information will be extracted from Mössbauer spectroscopy and neutron methods. Theoretical calculations will complement the experiment. The fellow and the host will combine their fields of expertise, the low-temperature physics and solid-state chemistry, to elucidate the phenomena behind the magnetocaloric effect in frustrated systems and ultimately to design efficient magnetocalorics that beat the present obstacles.

Keywords: magnetocaloric effect rare earth free magnetocalorics geometrical frustration thermal and quantum fluctuations