Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Biomimetic Restoration of Tooth Dentin via Deep Mineralization (REDEEM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Türkiye
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-10-02
Duration (months): 24.0
Total project cost (EUR): 157355.52
EU funding (EUR): 157355.52
Participants: 1
Project status: SIGNED

Dentin hypersensitivity (DH) is a prevalent health condition occurring in more than 50% of the population. Despite the upward trend of risk, there has not been a permanent solution to DH. An ideal treatment should reproduce a well-integrated mineral layer, mimicking the protective cementum tissue that covers exposed tubules and seals tightly by penetrating into them. Such restoration can be accomplished using peptides that epitomize mineralization properties of dental proteins. Proposed herein is the development of a novel approach called Deep Mineralization, that will enable biomimetic restoration of exposed dentin by forming a well-integrated acellular cementum-like protective mineral layer. This will be accomplished via four specific objectives that include: (i) Experimental selection of peptides via directed evolution paired with next-generation sequencing called Deep Directed Evolution to generate peptide datasets (big data); (ii) Development of protein-derived peptides via machine learning (ML) based predictive design platform (Biomineralization Intelligence) that is trained with big data and refined through (iii) High-throughput (HTP) validation assays, and eventually (iv) Establishing a peptide-guided remineralization methodology (Deep Mineralization) by mimicking the remineralization action of saliva in which remineralizing peptides bind to exposed dentin, recruit calcium and phosphate ions and synthesize an integrated acellular cementum-like mineral layer, thereby, restoring tooth’s natural protection. Aligned with the current vision of the EU that aims to adapt methodologies to generate big data and tools to enable fast-track discoveries with healthcare delivery, this study marks the onset of implementing ML and HTP screening methods into dental research. Successful completion of this project will result in a line of preventive oral care products with the long-term vision of establishing a molecular toolkit for complete tissue regeneration.

Keywords: demineralization,remineralization,dentin hypersensitivity,peptide guided tissue repair
Novel structural monitoring solution for safe and sustainable post-tensioned infrastructure (PT-SMS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-01-01
End date: 2019-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Collapsing buildings, bridges and other infrastructure are unfortunately still a common occurrence. Since 2000 more than 100 bridges have collapsed killing over 700 people and costing billions of euros in lawsuits, repairs and replacements. The recent Genoa bridge collapse is a tragic example. Many of the concrete infrastructure in Europe does not have structural health monitoring solutions (SHM) in place as a result of the high complexity and costs of available solutions. PT-SMS innovation project aims to commercialize a novel Structural Health Monitoring (SHM) solution for post-tensioned concrete. Post-tensioning is a popular method to strengthen concrete buildings, bridges, dams and other infrastructure. 3S'TECH has developed a unique strain-gauge based sensor system optimized for post-tensioned (PT) monostrand monitoring that is easy-to-install, low-cost, 95% accurate and durable (20+ years), thereby providing superior performance over current market solutions. Backed by a Big Data Platform and Artificial Intelligence, PT-SMS will allow infrastructure owners to ensure the safety of their structures while reducing OPEX by 25% through predictive maintenance. Construction companies on the other hand benefit from much higher control over the tensioning process drastically reducing delays and delivering high quality work. Its design simplicity allowing self-nstallation by PT construction workers will provide a fast path to market entry through partnerships with leading European PT companies such as VSL and Freyssinet. The SHM market for concrete is growing fast with bridges alone reaching 464 M€ and CAGR of 15.6%. Ptototype tests have already been successfully carried out at a VSL construction site. Upon full commercialization of our technology in 2021, 3S'TECH will establish a new niche market and grow its revenues from 0.92 M€ in the first year to over 5 M€ in the third year, reaching a ROI of 3.5 over the total expected investment of 0.9 M€.

Keywords: structural health monitoring,post tensioned concrete,big data,real time monitoring,strain gauges,condition based monitoring,predictive mainteance,safety
An effective and safe targeted therapy for treatment of Myasthenia gravis (TOL2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Myasthenia gravis (MG) is a rare disease affecting 2/10.000 people. Although being a rare disease, MG is the most common chronic autoimmune neuromuscular disease that causes weakness in the skeletal muscles, which are responsible for breathing and moving parts of the body, including the arms and legs. MG restricts patients from having a full participation in everyday activities, frequently leading to unemployment and reducing their quality of life. Many patients may eventually experience a myasthenic crisis, the treatment of which is very expensive. Such crises can lead to the death of the patient. There is currently no cure for MG and neither is there any cure in sight. Even though there are over 30 MG-related clinical trials currently in progress, most of them are only symptomatic treatments. Considering this urgent medical need, we are developing TOL2, an innovative therapy with potential to cure MG (not only symptomatic treatment). This will be the first therapy for MG that induces long-term remission. TOL2 is based on a tolerance-technology with potential to be developed for treatment of other autoimmune diseases. TOL2 has been granted Orphan Drug Designation by the US FDA. Toleranzia is a Swedish pharmaceutical research and development company. Our therapies utilize the immune system’s own intrinsic power to treat autoimmune diseases. Our mission is to develop innovative therapies that will cure autoimmune diseases. Our business strategy for TOL2 is to complete clinical phase IIa, and then to look for an agreement with a global pharma partner, who can or co-develop the therapy. Under this business model, revenue streams are obtained through upfront payments, milestone payments and royalties on product sales. Considering total project cost of €5,6 m during years 2019-2021, upfront payments above €14 m and 20% royalties over sales, the NPV of the investment calculated (WACC 10%) will surpass €257m by 2029.

Keywords: myasthenia gravis,autoimmune disease,orphan drug,disease specific treatment
Reinventing bioplastic: CO2 + sunlight = PLA (RePLAy)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-12-01
End date: 2021-11-30
Duration (months): 24.0
Total project cost (EUR): 3234375.0
EU funding (EUR): 2264062.5
Participants: 1
Project status: CLOSED

The demand for plastic packaging is predicted to triple to >285 million tons by 2050, bringing on well-recognized problems around the use of fossil feedstocks. Biodegradable bioplastics, especially polylactic acid (PLA), offer a promising solution to replace plastic packaging. However, the production of PLA currently depends mainly on food crops as key feedstock and requires significant amounts of agricultural land and fresh water. There is a urgent need for innovative bioplastic production technologies that do not take over our land, water and food production system. Dutch applicant Photanol leverages a proprietary technology to produce lactic acid, the key ingredient for PLA, directly out of CO2 and sunlight. Its revolutionary platform technology is based on the combination of optimized bacterial strains and tailor-made photo-bioreactors, enabling direct conversion of the limitless available CO2 feedstock into lactic acid and a production efficacy that is 7x higher than crop plants. In the process, 1.6 tonnes CO2 are captured per ton lactic acid and 24x less land and 25x water are used compared to current methods. Photanol is led by experienced biotech entrepreneurs, chemical industry representatives and scientific leaders. The award-winning biotech SME has reached important up-scaling milestones obtaining permits and successful construction and operation of a first-of-a-kind outside pilot plant. As next step, Photanol aims to construct a full commercial production plant (operational in 2024, with an expected annual gross profit of €75 million). This project will address all technical, operational, economic and financial barriers before scale-up to commercial size. The project will allow Photanol to demonstrate the commercial potential of its technology and expand the company from 21 to >70 FTE by 2024. Ultimately, Photanol aims to become a key enabler of a revolution in the chemical industry that will decouple any kind of chemical from fossil feedstocks.

Keywords: bioplastic,polylactic acid,lactic acid,biodegradable,packaging,plastics,co2 feedstock,cyanobacteria
Development of a new palletiser/depalletiser control system for optimum efficiency (CANEFF)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-05-01
End date: 2016-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Located in Emilia-Romagna (Italy), CLEVERTECH (€30 million turnover; 72 employees [2014]) is a company that designs, manufactures and commercialises equipment and systems for the end-of-line automation of the largest producers of consumer goods. From our establishment in 1987, innovation and dynamism have been the key elements to our success, creating solutions for our customers, building a complete range of palletisers and depalletisers designed to meet their most specific requirements in terms of productivity and product features. We have gradually become a leader partner for several multinational companies (e.g. Princes, P&G, Nestlé, or Bonduelle) in the food, can making, beverage and cosmetic fields. To sustainably grow in the manufacturing world where the competition with the low-cost countries is particularly strong, our philosophy has always been, since day one, to distinguish ourselves by providing the international market with high quality and customized products. Listening to our customers’ feedbacks and concerns on productivity and traceability of their products, we have been working on the development of an automated system, easily installed on existing and new palletiser/depalletiser machines, that redefine end-of-line efficiency thanks to its monitoring of the exact number of products contained in a finished pallet and its optimization of their arrangement in order to increase both productivity of the lines and traceability of packed/unpacked items. Our project, called CANEFF, will lead in long-term profitability for both customers and our company, as it will allow us to strengthen our business position as well as reach new clients with the retrofit of their machinery, for a gain in our revenue reaching €7.8 million of accumulated revenues by 2022.

Keywords: palletiser,depalletiser,productivity,efficiency,traceability,end of line,can making,can arrangement,control system
Open Payments Eco-system (OPE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-2-2014, 2014)
Start date: 2015-05-01
End date: 2017-09-30
Duration (months): 29.0
Total project cost (EUR): 4162916.25
EU funding (EUR): 2500000.0
Participants: 2
Project status: CLOSED

The aim is to enable the widespread development of innovative payment applications with the active involvement of financial institutions (e.g. banks) providing supporting transaction services by creating an Open Payments Eco-system (OPE). The OPE is the critical step in widening access to payment services and to alternative, open, collaborative, lower cost methods of delivering payment applications to end users (particularly SME’s) who want to make use of payment services within their business. The Eco-system enables the SME developer community to provide creative new payment applications to the market and offers a high degree of re-use of common application components. OPE has the potential to fundamentally disrupt the current creation and delivery mechanisms for payment services, by providing for the low-cost creation of quality assured payment applications and the building and delivery of payment services, in a controlled and regulatory-compliant environment. Forecasting reports (Visa Europe – 2011 and PSE Consulting – 2013) indicate a potential market for prepaid payment services in corporate and consumer segments in Europe of >€140bn by 2020. The market application will initially be launched in the UK (2017-18) but quickly rolled out into the rest of Europe (2018 onwards) leveraging the expected OPE common coded regulatory compliance, with Italy, Spain, France and Germany being the focus. Ixaris specialises in the development of innovative global applications based on open-loop prepaid card schemes and the OPE will add a unique infrastructure to its product portfolio. This will be achieved by opening up the established payment infrastructure and in doing so disrupting the traditional way in which innovation in payments takes place within the current established banking eco-system.

Keywords: innovative payment applications,financial services,payments industry,open banking
Large Organic Robust Imager for X-ray sensing (LORIX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: A new generation of components and systems: Engineering of advanced embedded and energy and resource efficient components and systems
Action type: Innovation actions
Countries involved: Germany,Germany,Germany,Israel,Finland,France,France,Netherlands,United Kingdom
Call: Advanced Thin, Organic and Large Area Electronics (TOLAE) technologies (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2018-07-31
Duration (months): 42.0
Total project cost (EUR): 9726781.25
EU funding (EUR): 7289595.88
Participants: 14
Project status: CLOSED

General X-ray image sensing is undergoing a major transition away from analog solutions towards Direct Radiography using digital Flat-Panel Detector (FPD) technology, offering immediate imaging, large productivity, lower dose and portability. LORIX will develop, prototype and demonstrate large area X-ray FPD detectors enabled by TOLAE technology by combining a printed Organic Photo Diode (OPD) with existing Thin Film Transistors active matrices (TFT), in security, health and Non Destructive Testing applications. LORIX will consider two complementary technology routes for effective market introduction: - The short term (2020), low risk route, based on Organic Detector On Glass (oDOG) concept, integrates printed OPD layer on a-Si active matrix on glass, used for displays. This will result in highly competitive organic FPDs with higher performance at lower manufacturing cost. - The medium (2022) term route, relying on Organic Detector On Foil (oDOF) concept, integrates a printed OPD on an organic TFT active matrix on foil. This full organic sensor on foil with improved mechanical robustness and lightweight will enable an easier penetration into nomadic X-ray markets and later will pave the way for dynamic, curved and flexible image sensors. LORIX partners are complementary and cover the full TOLAE value chain: material supplier, equipment manufacturers, companies & research organisations for OPD & OTFT design & integration, companies for production of sensors and full systems. Major OLAE European pilot facilities, PICTIC in Grenoble, Plastic Logic in UK & Germany, will be used for effective industrial exploitation of the products in Europe. Entering an existing business, LORIX will have direct access to end users in the targeted applications. LORIX innovations will strengthen the European industries leadership on X-ray market and will contribute to build a complete value chain with manufacturing capabilities in Europe for large area organic sensors applications.

Keywords: tolae large area sensors,x ray detectors,organic photo diode,otft,foil,manufacturing,reproducible,yield,reliable,lightweight,pilot facilities,security,medical,ndt applications
Monitoring Meat Texture To Optimize Slicing Yield And Reduce Wasted Meat In High-Speed Slicing Lines (SliceWatch)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2014, 2014)
Start date: 2014-09-01
End date: 2015-01-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Meat processing industry generates an annual turnover of €160.6b in the EU-25, from which 50% corresponds to meat processing SMEs. Over the past years, the demand for sliced cured meat products has steadily grown driven by the higher acceptance of consumers for ready-to-eat products. Despite the growing market demand, operational costs of automated slicing lines are significant. Meat losses represent over 5% of the total costs, and are responsible for wasting tons of meat yearly in Europe. About t10,000 and t3,0000 of meat are annually lost during bacon and ham slicing operations, respectively, with an impact of over €110M. To a great extent, the variability in meat texture is responsible for these losses. Besides the associated economic and environmental implications, variations in product texture are responsible for frequent line stoppages, and reduced processing throughput. Based on our patent-pending electromagnetic scanning technology, we aim at developing a non-destructive inspection system to evaluate “in-line” meat texture before slicing. SliceWatch would allow diverting soft or hard pieces from the slicing line, thus preventing line stoppages and minimizing meat losses. This technology shall constitute a breakthrough innovation in the meat processing sector, and shall allow meat producers to reduce manufacturing costs and waste generation. Being a niche market, we estimate the total market value for SliceWatch in Europe in €150M. We expect to generate a NPV of €6M over a 5 years period after starting commercialization (ROI=3.9). In collaboration with a potential client, we have already assessed the economic and technical feasibility of the project in a production line of sliced cured ham. Through this innovation project we aim at: (1) completing the technical feasibility study, and elaborating a detailed business plan – Phase I; and (2) developing and demonstrating a complete qualified system (TRL8) – Phase II.

Keywords: food technology,meat processing,non destructive testing,electromagnetic scan
Site-selective chemical pyrophosphorylation of proteins using tag-and-modify approach. (PyroPhosphoProtein)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Post-translational modifications (PTMs) occur on nearly all proteins in eukaryotic cells to diversify their proteome. These chemical modifications of various amino acids side chains can influence protein association with other biomolecules, or control cellular signal transduction networks and the activity of enzymes. Reversible protein phosphorylation is one of the most common PTMs. It is considered as a signalling mechanism involved in almost all cellular processes. On the other hand, protein pyrophosphorylation mediated by the inositol pyrophosphate messengers was discovered recently and its function on proteins is completely unknown. Up to date, direct evidence of its role in vivo is still missing. Exploring the potential role of protein pyrophosphorylation is limited by lack of a robust method of installing pyrophosphate residue in desired position of full length proteins. Here we propose chemical site-specific pyrophosphorylation of proteins using “tag-and-modify” approach. It relies on expression of protein bearing cysteine in the position of interest. The cysteine is then chemically converted to dehydroalanine (“tag”), which reacts with various sulphur or carbon nucleophiles under mild conditions to introduce pyrophosphate PTM mimics (“modify”). The method allows preparation of not only pyrophosphorylated proteins, but also their phosphatase resistant analogues. These will be invaluable for mechanistic studies of pyrophosphorylation reversibility and its biological role. As a proof of concept, well defined chemically pyrophosphorylated transcriptional factor GCR1 will be prepared by proposed strategy. The influence of GCR1 pyrophosphorylation on interaction with GCR2 will be explored, since this is assumed to control transcription of glycolytic genes in yeast. Our new technique for the site-specific chemical synthesis of pyrophosphoproteins will provide long awaited tool to gain a better understanding of the physiological role of this novel PTM.

Keywords: pyrophosphorylation,post translational modification,protein protein interactions