Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Urbanization in China's South-western Borderlands. The case of Jinghong, Xiguangbanna (URBAN_CHINA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-01
End date: 2020-12-30
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 2
Project status: CLOSED

This interdisciplinary research project aims to study urbanization in China’s non-metropolitan and non-industrial ethnic-diverse border regions under post-socialism. Literature on urbanization in China focuses mainly on traditional large metropolitan or industrial cities in the center with Han majority population, and examines either the structural or the subjective features of urban development. The complex dynamics of urbanization and power relations in the new cities in the periphery remain understudied. The project fills this knowledge gap, by exploring how urbanization intersects with tourism growth and in-migration and affects ethnic relations in Jinghong, a fast-growing city in China’s south-western borderlands. In Jinghong, the Han, China’s ethnic majority, have become the city’s drivers of urban and economic development, competing over land, resources and political power with long-term Dai/Tai minority ethnic residents. Unconventionally drawing on methods of Anthropology, Urban Planning, Architecture, Urban Geography, and Sociology, this pioneering project aims at producing a theoretically and empirically innovative analysis that combines structural, socio-economic, and political examination with an investigation of subjective and experiential aspects of urbanization, highlighting conflicts, mindsets, and prejudices in the day-to-day urban interactions between Han majority and ethnic minority citizens and the state. I expect that the development of this project will profoundly impact my career. Thanks to training provided by the Department of Architecture, Design and Urban Planning, at the University of Sassari, Italy’s utmost interdisciplinary institution of Architecture and Urban Planning, I will acquire new skills and build fruitful relations with European institutions and scholars. The training, network and publications of the project’s outcome will allow me to increase my possibilities of obtaining an ERC Grant.

Keywords: urbanization,china,urban planning,urban studies,ethnic relations,urban anthropology
Treatment of liver disease and cancer prevention (PRELICAN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France,France
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-06-01
End date: 2018-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

Advanced liver disease and cancer is the only major cause of death still increasing each year. Major causes include hepatitis B and C viruses, alcohol and non-alcoholic fatty liver disease/steatohepatitis (NAFLD/NASH). A major contributing factor to the increasing incidence and mortality of liver disease is the staggering rise in obesity. The absence of effective therapeutic options for NAFLD/NASH, advanced liver disease and cancer contribute to the poor prognosis and the high cost associated with patient care. We have established a tractable and clinically relevant human cell-based model system in which viral infection, ethanol or free fatty acids induce a clinical gene expression signature robustly predicting liver disease progression and long-term HCC risk in cirrhotic patients. Using this model we identified compounds as HCC chemopreventive agents. Aiming to evaluate these compounds for future clinical development and potential commercialization we will perform proof-of-concept studies in state-of-the-art mouse models for NASH and hepatocarcinogenesis. Specifically we will assess the therapeutic effect on liver inflammation, steatosis, fibrosis and HCC development and investigate its safety in long-term administration. With the completion of this program we expect to obtain a robust proof-of-concept data package as a first- or best-in-class compound for treatment of chronic liver disease and prevention of HCC.

Keywords: liver disease,nafld,nash,antibody,drug development,animal model,steatosis,fibrosis,liver cancer,hepatocarcinogenesis
Efficient mixing method at the microscale for Time-Resolved Serial Femtosecond Crystallography (X-MIXING)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2022-02-28
Duration (months): 29.0
Total project cost (EUR): 197529.6
EU funding (EUR): 197529.6
Participants: 2
Project status: CLOSED

X-MIXING is an interdisciplinary project aimed at conceiving an efficient mixing method at the microscale suitable for triggering not-light sensitive biochemical reactions in the application of Time-Resolved Serial Femtosecond Crystallography. Nowadays, the temporal resolution of this type of dynamic structural biology analysis with X-ray Free-Electron Lasers is limited by the minimum mixing time that current methods can produce. As it is shown in a proof-of-concept, an exciting combination of electrohydrodynamic fields and momentum transfer lead to a significant variation of the spatiotemporal scales within the convection-diffusion mechanism. So, this configuration can potentially generate mixing from 100 to 1000 faster than current means do. Besides, its versatility would enable not only to reduce the mixing time substantially, but also to induce jumps in PH and temperature that would additionally open horizons concerning new types of triggering reactions in the field. These critical features have the potential to become this original configuration in a key to take full advantage of the recent significant investment, over 1,22 billion euro (2005 value), paid by European Union and partners for the construction of the European XFEL (Germany), whose user operation started in September 2017. To explore and elucidate the underlying physical limits of the proposed method, the research methodology of this project will embrace different approaches such as micro-PIV experiments, numerical simulations, and scaling analysis.

Keywords: mixing,microscale flows,free surface flows,electrospray,flow focusing,electrohydrodynamics,structural dynamic biology,time resolved serial crystallography
Skin Keratinocyte Stem CEll proliferatioN in field CancErisation (SKin SCiENCE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Epithelia provide a protective barrier that exposes them to environmental carcinogens. Cancers of epithelial tissues, called carcinoma, account for 85% of all cancers and 78% of all cancer associated mortality. Epithelia undergo continual proliferation and renewal with hierarchical differentiation dependent upon long lived adult tissue stem cell. Many carcinomas arise from pre-malignant transformation, intraepithelial neoplasia referred to as field cancerisation (FC), which is an area that can give rise to multiple primary cancers. FC is a feature of malignancies involving the head and neck,oesophagus, stomach, lungs, cervix, vulva, bladder, colon, breast, ovary, pancreas, prostate and skin. By studying skin FC in a rare genetic disease, Epidermodysplasia verruciformis, and utilising a mouse model of HPV8 infection, I uncovered a novel keratinocyte stem cell (KSC) basis, driven by ΔNp63 expression, common to all causes of skin FC. I now propose to build on this original finding and utilising an innovative approach to determine the cell signalling pathway involved in expansion of this novel KSC population. I hypothesise that the common mechanism in skin FC, potentially relevant to FC in other tissues, arises from dysregulation of a signalling pathway that results in a switch from p63 TA to ΔN isoforms resulting in expansion of a KSC population that is susceptible to transformation. I propose to use multiple strategies to: 1)Identify the HPV8 gene that is responsible for ΔNp63 overexpression, 2)Determine which signalling pathway(s) is/are activated in HPV8tg mice, resulting in ΔNp63 overexpression 3)Determine the pathway(s) is/are responsible for ΔNp63 overexpression in human skin FC; and 4)Determine whether immunosuppression promotes SCC formation in HPV8tg mice. I have assembled expert international collaborations and relevant partner organisation to help me in this project, so that I can identify novel therapeutic targets for future drug discovery and development.

Keywords: field cancerization,keratinocyte stem cell,organ transplant recipient
Exploring new technologies for the next generation pulse tube cryocooler below 2K (EngPTC2)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-02
End date: 2021-09-01
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

With the development of physics and new technologies, it has proposed some new challenges for the traditional 4K pulse tube cryocooler (PTC). The next generation 4K PTC with smaller size, lower power consumption, higher efficiency and lower temperature is anticipated. This project aims to develop a new type 2K PTC with 3He-4He mixtures as working fluid. This work will not only explore its internal new cooling mechanism, but also break up the limit temperature of Stirling type PTC, which would extend the application areas for the next generation PTC, especially for the areas of space exploration and quantum computing. The proposed new type PTC will use the unique properties of 3He–4He mixtures to improve its performance. To implement this project, it need first to clarify the underlying working mechanism of mixture gas in PTC, which will provide theoretical foundations for designing this kind of PTC. And then to develop experimental system to valid theoretical model and explore its limit temperature. Specifically, the Fellow will (a) develop a full temperature range thermal-properties database of 3He-4He mixtures, to be used to CFD simulation; (b) develop a theoretical and simulation model to clarify the mechanism of cooling effect in this PTC; (c) experimental verification the numerical results and optimization of its performance. The new results of this project will help us to shape the emerging research area of next generation PTC. The Fellow is currently at forefront of international advances in 4K PTC. With support from the hosting institutions LNE/Cnam, a timely award of the Marie Skłodowska-Curie Fellowship will provide the applicant the necessary resources and access to expertise to make rapid progress in this emerging research area and become an independent researcher, ready to compete globally.

Keywords: pulse tube cryocooler,mixtures fluid,low temperature,cfd simulation,thermal compressor
Microscopic Surface Dynamics of Pt and Pt Alloy Electrocatalysts under operation conditions (DYNECAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

By employing the in-situ electrochemical video-rate scanning tunneling microscopy (STM) at well-defined single crystal electrodes, we are going to study the surface dynamics of the atoms on Pt(111), Pt(553), Pt(533), Pt(111)-Cu and Cu/Pt(111) surface alloy in the absence and presence of oxygen gas, with the aim to probe and understand the restructuring of Pt and Pt alloy catalyst of the fuel cell cathodes under the operation conditions. Simultaneously, in-situ electrochemical surface Raman spectroscopy will be used to identify the surface species and their interaction with electrodes, using a version employing shell-isolated nanoparticles that is suitable for single-crystal electrodes. On the basis of the observations of STM and Raman spectroscopy, theoretical calculations based on density functional theory (DFT) and Monte Carlo simulations will be carried out to understand the surface electronic structures and to mimic dynamical migrations of the surface atoms. This should yield deep insight into the essential dynamic properties and the impact on the restructuring of these electrocatalysts under operation conditions.

Keywords: electrochemistry,surface science,scanning tunneling microscopy,fuel cell reactions,catalyst stability
Performativity as Curatorial and Artistic Praxis (PERFORM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

“PERFORM” is a compelling, international, interdisciplinary, and intersectoral project that will create an unprecedented dialogue between the concept of “performativity” and contemporary European curatorial and performance practices through the inauguration of a ground-breaking theory of performativity as curatorial and artistic praxis. Supervised by renowned critical theorist Prof. Sonia Arribas, and hosted by the Institute of Culture in the Departament d’Humanitats at Pompeu Fabra University, the project is modeled according to a reciprocal transfer of knowledge that will increase the excellence of all participants, while making a strong impact on European audiences through the communication and dissemination of state-of-the-art knowledge that will foster exchange between the humanities and the arts. It consists of a tailor-made program of training in live arts curation and contemporary European performance art, short research stays to study the curatorial initiatives of the Biennale de Venezia, Performatik Brussels, and the Museu d’Art Contemporani de Barcelona, and the artistic practices of Anne Imhof (DE), Alex Baczynski-Jenkins (PL), and Santiago Sierra (ES), presenting two papers at international symposia, publishing two peer reviewed articles, teaching, organizing a symposium and a journal launch, etc. The project will culminate in the publication of a monograph with the Performance Philosophy Book Series (Rowman and Littlefield) that will be mentored by secondment supervisor, Dr. Laura Cull Ó Maoilearca at the Academy of Theatre and Dance at the Amsterdam University of the Arts. Framed methodologically within the field of performance philosophy, “PERFORM” will illuminate the shared mechanisms between linguistic and gender performativity and performance art, account for the recent explosion of performance in major art institutions, and demonstrate how performance and performativity are emblematic of the politics and preoccupations of 21st century Europe.

Keywords: performativity,performance art,performance,live arts curation,curatorial studies
Superconducting Diamond Quantum Nano-Electro-Mechanical Systems (SUPERNEMS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2021-09-30
Duration (months): 75.0
Total project cost (EUR): 2734048.75
EU funding (EUR): 2734048.75
Participants: 1
Project status: CLOSED

In this project, the fabrication and characterisation of all diamond superconducting Nano-Electro-Mechanical Systems (NEMS) is proposed for the investigation of macroscopic quantum states. This involves state of the art Chemical Vapour Deposition (CVD) of diamond, doping, nanofabrication and modelling of devices. The fundamental properties of superconducting diamond, the associated mechanical properties of diamond NEMS and the characterisation of low temperature and low dimensional quantum effects will be investigated. Critically, the unprecedented resonant frequencies of diamond cantilevers allow the possibility of cooling cantilever devices down to the ground state. Coupled with its superconducting-based read out possibilities, this material offers new opportunities for challenging the Standard Quantum Limit, the study of quantum entanglement and the fabrication of superconducting diamond Qubits. This work is highly ambitious, as it aims to manipulate systems by exploiting fundamental quantum limits. However, the applicant has already demonstrated the individual constituents of this approach and thus it is not reckless to propose to integrate them.

Keywords: diamond,chemical vapour deposition,mems,qubit
Conflict and Cooperation in the EU Heterarchical Legal System (EUTHORITY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2021-02-28
Duration (months): 66.0
Total project cost (EUR): 1475150.0
EU funding (EUR): 1475150.0
Participants: 1
Project status: CLOSED

Supranational legal regimes are increasingly enforced by multi-level, non-hierarchical court systems, in which judges at the upper, supranational echelon do not have the power to reverse domestic court decisions. Yet the incentives and dynamics that shape the complex patterns of conflict and cooperation observed in the most important of all such court structures, the EU legal system, are still poorly understood. To what extent are domestic courts able to negotiate the terms of their cooperation with the Court of Justice? How do national courts differ in that respect? Are the non-compliance threats issued by domestic courts all equally credible? Do the rare cases where these threats have been put to execution pose a systemic risk to the authority of EU law? How are the domestic courts’ incentives to cooperate with EU judges affected by the sort of political backsliding witnessed in Hungary and Romania in recent years? Our interdisciplinary research project addresses these puzzles of legal integration with the avowed aim of helping judges and policy-makers make more informed choices when faced with compliance problems in the judicial realm. Grounded in a general theory of judicial behaviour, our generic hypothesis is that the authority of EU law at domestic level is determined by domestic politics as well as by judicial attitudes towards integration. EUTHORITY seeks to refine this hypothesis using game theoretic modelling to analyse strategic interactions among the Court of Justice and domestic courts and politicians. Theory-building combines with a large-scale data-collection effort. We undertake to compile longitudinal data on the institutional characteristics and doctrinal responses to legal integration of 68 domestic apex courts across the EU 28 Member States. With a view to construct an annual, court-specific index of legal integration, we also conduct an expert survey asking academic lawyers and practitioners to assess their courts' attitudes towards EU law.
Long-range electrodynamic INteractions between proteinS (LINkS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Sweden,France,France,France,Netherlands
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 3090575.0
EU funding (EUR): 3090575.0
Participants: 9
Project status: SIGNED

LINkS will change the paradigm of the self-organization of the intracellular living matter by demonstrating the existence of Long-range ElectroDynamic Interactions (LEDIs) between proteins. LEDIs may act as a long distance protein-protein attractive mechanism expanding above several hundred of Angströms that could explain the high spatial organization and coordination of biomolecular reactions; responsible for the transmission of information in cells. LEDIs result from condensation phenomenon, characterized by the emerging of the mode of lowest frequency; expected in the TeraHertz (THz) frequency band. However, to date, LEDIs have eluded detection, partly because previous theoretical predictions were incorrect, but also because performing THz spectroscopy in aqueous media is a well-known technological roadblock not yet overcome. LINkS will develop a breakthrough lab-on-chip THz biosensor technology to investigate LEDIs between proteins, from in-vitro to in-vivo. No competing or alternative technology exist yet. To this end, LINkS consortium gathers interdisciplinary expertise including theoretical biophysics, cell biology, nanotechnology and microfluidic engineering. Three academic partners and two SMEs, from four European countries will work in strong collaboration, across the traditional boundaries of their disciplines, to develop a disruptive lab-on-chip THz biosensor able to investigate LEDIs in the real complexity of biological systems. LINkS technology will effectively address proteomic analysis and related markets for the benefit of society as a whole. In the long-term, its ramifications will have significant benefits for drug discovery, biomarker identification and associated personalised therapies, and for understanding the influence of electromagnetic fields on living organisms; thus opening up new fields of research in medicine and biology.

Keywords: out of equilibrium phenomena,collective oscillations,long range interactions