Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Atomic Scale Modeling of Concentrated Multi-Component Alloys (ATMODALLOY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-11-01
End date: 2016-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The main goal of this proposal is to systematically develop atomic scale models of concentrated multi-component alloys. To this end, we will derive empirical interatomic potentials for W and Ti-based alloys and carry out simulations of thermodynamic, kinetic and mechanical properties. In this fashion, we aim to provide a pathway to an improved atomic scale understanding of these materials. The unique features of the present proposal are a novel approach to modeling the chemistry of multi-component systems and new algorithms for simulating alloy microstructures taking into account structural, chemical and temperature effects. Most alloys contain at least three key components. Yet at present almost all interatomic potentials are constrained to the description of binary interactions. We will adopt a recently developed scheme devised to overcome these limitations and generate interatomic potential models for concentrated multi-component alloys. Based on these models we will carry out an extensive characterization of phase diagrams, short and long-range order, precipitation, meta-stable phases, and mechanical properties. To this end, we will apply a novel hybrid molecular-dynamics/Monte Carlo algorithm that is capable of simultaneously taking into account structural, chemical and temperature effects. The method will be extended to allow for a variable total number of particles to enable studies of general solid-solid interfaces.

Keywords: p113 thermodynamics,p201 structure of solids and liquids,p202 mechanical and acoustical properties of condensed matter,p217 statistical physics (condensed matter)
Mapping structural variation on native chromosomal DNA – a single molecule approach (DNALIGHTMAP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2016-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This proposal seeks to utilize single molecule optical detection to directly visualize and analyze genome structural and copy number variation (SVs & CNVs) spanning up to hundreds kb of native chromosomal DNA . The project focuses on a pathogenic macro satellite repeat in the subtelomere of chromosome 4q that is linked to the third most common inherited muscular dystrophy, Facioscapulohumeral muscular dystrophy (FSHD). Specific sequences on subtelomeres are labeled with fluorescent molecules via enzymatic reactions to create a unique, chromosome specific fluorescence pattern. The DNA is then stretched in thousands of parallel nanochannels by electrophoresis and imaged on a fluorescence microscope. The resulting patterns along the DNA backbone are compared to a reference map computed from the known genome sequence and variations from the reference are classified and characterized. Specifically, we will be able to count the exact number of repeat blocks in pathogenic vs. non-pathogenic chromosomes. The immediate outcome of this project is a powerful diagnostic tool for FSHD and a proof of principle for single molecule, high throughput structural variation analysis on a genomic scale.

Keywords: genome structural varition,cnv,fshd,optical mapping,nano-channels,l201 genomics - comparative genomics - functional genomics,l207 quantitative genetics,l210 bioinformatics
Sound Localization by Neuronal Populations in the Rat Auditory Cortex (SOUNDSOURCE_RAT_AC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-05-01
End date: 2017-04-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

How does the accuracy of sensory representations constrain the ability of the organism to perform perceptual discriminations? In this project, we will address this issue by characterizing the activity of populations of neurons in the rat auditory cortex while they perform a two-alternative forced-choice discrimination task for detecting sound location relative to the midline. We will first establish how location and spectral features of sound are represented by cortical populations under anesthesia, and subsequently during performance of the sound localization task. Due to the design of our discrimination task, analysis of the patterns of co-variability in the recorded sensory responses will allow us to elucidate whether the auditory cortex is primarily concerned with maximizing information about auditory stimuli, or whether it constructs representations which are useful for the animal in the context of its current behavioral goals. We will also investigate whether population activity and behavioral choices are correlated in a trial-by-trial basis. By understanding how the activity of multiple neurons has to be combined in order to best predict behavioral choices we expect to learn about the computations that the auditory cortex is performing in order to classify the location of sounds relative to the midline.

Keywords: awake-behaving,circuit dynamics,temporal correlations,choice probability,spontaneous activity,computational modeling
Physiological and Behavioural Photoprotective Processes against Oxidative Stress in Marine Photosynthetic Symbioses (PHOTOSYMBIOXIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-12-01
End date: 2014-11-30
Duration (months): 24.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Marine sacoglossa sea slugs, mainly of the genus Elysia, have developed a unique functional nutritional mode in which they gain the capacity for phototrophic-mediated carbon acquisition by sequestering macroalgae plastids into tubule cells of their digestive diverticula (kleptoplasty). as occuring in algae and plants, exposure to excessive light is expected to be a major cause of stress to the photosynthetic apparatus of photosynthetic symbioses. When the absorbed light energy exceeds the capacity of photochemical pathways, reactive oxidative species accumulate in the cell and cause damages to the photosynthetic apparatus (photoinhibition), mainly through the degradation of protein D1 in photosystem II. To cope with high ambient light levels, algae and plants have developed a range of physiological photoprotective processes, the most important being the xanthophyll cycle, the antioxidant enzyme system and the de novo synthesis of D1 protein. In the case of marine photosynthetic symbioses typically inhabiting surface waters or intertidal habitats, the efficient functioning of photoprotective mechanisms may be of crucial importance for their survival as photoinhibition reduces the amount of photosynthetically fixed carbon made available to the animal host and damage the photosynthetic apparatus in the chloroplast. Anatomical and behavioural traits can also enhance the performance and functional longevity of chloroplasts in different light regimes. This adaptation would be functionally equivalent to chloroplast avoidance movements and leaf fold described in plants, and the migratory behaviour of motile microalgae, shown to provide effective photoprotection against photoinhibition. This work will provide new insights into the photophysiology and photobehaviour of a marine photosynthetic symbiose model occurring in North-eastern Atlantic temperate waters, advancing the knowledge on the performance and functional longevity of kleptoplasts.

Keywords: elysia,kleptoplast,photobehaviour,photophysiology,photoinhibition
AUTOPHAGY AND VIRULENCE OF HEPATITIS C VIRUS (HEPATG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-08-01
End date: 2016-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Autophagy is a major intracellular pathway for cellular homeostasis. It also plays an essential role in antiviral response against diverse pathogens. Indeed, in addition to the removal of viral protein aggregates from the cells, autophagy is emerging as a key regulator of viral propagation by regulating positively or negatively the secretion of interferon α/β (IFNα/β) and inflammatory molecules, known to be essential to initiate antiviral responses. However, certain pathogens such as, for example, the hepatitis C virus (HCV), which chronically infects over 130 million peoples in the word and thus has a substantial impact on public health, have developed mechanisms to inhibit the completion of autophagy. Moreover, we demonstrated that HCV even uses autophagy proteins for the translation of incoming viral genomes in newly infected cells (Dreux et al., PNAS 2009). Thus, this CIG proposal is based on our princeps data and aims at determining the functional relationships between autophagy and HCV. Therefore, we will define the molecular mechanism whereby HCV co-opt the autophagy regulators to initiate the translation of its genome. In addition, we will decipher the mechanism of inhibition of autophagy completion by this virus and its impact on viral replication. Furthermore, we will analyze the regulation by autophagy proteins of antiviral molecules production during HCV infection. Finally, this project will entail at determining the role of autophagy-virus interplay during in vivo infection using mice reconstituted with a human liver that we recently established in the lab and that are robustly susceptible to HCV infection. Those complementary analyses will permit to further understand the regulation of viral infection by autophagy and will contribute to the design of better therapeutic strategies against HCV.

Keywords: virus,autophagy,antiviral signaling,hepatitis c virus,replication,rig-i,tlr,autophagosome
sunliquid® large scale demonstration plant for the production of cellulosic ethanol (SUNLIQUID)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable fuel production
Action type: Collaborative project
Countries involved: Germany,Austria,Germany,Hungary,Germany
Call:  (FP7-ENERGY-2012-2, 2012)
Start date: 2014-04-01
End date: 2020-03-31
Duration (months): 72.0
Total project cost (EUR): 93731733.53
EU funding (EUR): 23000000.0
Participants: 7
Project status: CLOSED

The aim of the proposal is to build a sunliquid® pre-commercial industrial scale demonstration plant for the production of lignocellulosic ethanol based on Clariant Produkte (Deutschland) GmbH’s (CPG) sunliquid® process. The sunliquid® technology is an innovative process for the production of cellulosic ethanol from lignocellulosic feedstock. It features highly optimized enzymes for maximum yield, an integrated enzyme production to ensure lowest production costs, simultaneous C5 and C6 fermentation which increases the overall ethanol yield by about 50 % and an energy saving separation technology. The resulting cellulosic ethanol shows CO2 emission savings of almost 95 %, the process is energy self-sufficient as the whole process energy is obtained from the residual lignin fraction. For this purpose work packages were designed to reproduce the entire value chain. Feedstock supply including transportation and selection of an appropriate plant site will be assessed by project partners ExportHungary and BayWa. Basic and Detail Engineering will be performed for full scale-up of the process into a commercial plant taking into account the experience from the demonstration site in Straubing (Germany) and other large scale production plant construction projects of the applicant CPG. Clariant Products Ro SRL (CPR) as the operator and owner of the plant will be responsible together with CPG for the construction, commissioning and operation of the plant. Furthermore, applicant CPG will secure the supply of high quality starter cultures including stringent quality controls and management. The innovative biocatalysts produced from theses starter cultures are of central importance for the ramp-up and operation of the plant. To demonstrate commercial viability distribution and testing of the cellulosic ethanol will be focused in another work package. A full life cycle assessment (LCA) of the process will assess and confirm the overall sustainability of the process supported be in depth expertise of the Energieinstitut Linz. Project partners IBB Netzwerk and BayFOR will be responsible for the dissemination of project results, to ensure knowledge transfer and maximum impact.

Keywords: large scale production,lignocellulosic ethanol,technology development,process design,scale up,value chain
Amyloid fibril cytotoxicity: new insights from novel approaches (AMYTOX)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: United Kingdom
Call:  (ERC-2012-ADG_20120314, 2012)
Start date: 2013-05-01
End date: 2019-04-30
Duration (months): 72.0
Total project cost (EUR): 2498465.0
EU funding (EUR): 2498465.0
Participants: 1
Project status: CLOSED

Despite the discovery of amyloidosis more than a century ago, the molecular and cellular mechanisms of these devastating human disorders remain obscure. In addition to their involvement in disease, amyloid fibrils perform physiological functions, whilst others have potentials as biomaterials. To realise their use in nanotechnology and to enable the development of amyloid therapies, there is an urgent need to understand the molecular pathways of amyloid assembly and to determine how amyloid fibrils interact with cells and cellular components. The challenges lie in the transient nature and low population of aggregating species and the panoply of amyloid fibril structures. This molecular complexity renders identification of the culprits of amyloid disease impossible to achieve using traditional methods. Here I propose a series of exciting experiments that aim to cast new light on the molecular and cellular mechanisms of amyloidosis by exploiting approaches capable of imaging individual protein molecules or single protein fibrils in vitro and in living cells. The proposal builds on new data from our laboratory that have shown that amyloid fibrils (disease-associated, functional and created from de novo designed sequences) kill cells by a mechanism that depends on fibril length and on cellular uptake. Specifically, I will (i) use single molecule fluorescence and non-covalent mass spectrometry and to determine why short fibril samples disrupt biological membranes more than their longer counterparts and electron tomography to determine, for the first time, the structural properties of cytotoxic fibril ends; (ii) develop single molecule force spectroscopy to probe the interactions between amyloid precursors, fibrils and cellular membranes; and (iii) develop cell biological assays to discover the biological mechanism(s) of amyloid-induced cell death and high resolution imaging and electron tomography to visualise amyloid fibrils in the act of killing living cells.

Keywords: protein aggregation,amyloid structure,single molecule fluorescence,force spectroscopy,electron microscopy and imaging
Demonstration of methods and tools for the optimisation of operational reliability of large-scale industrial wind turbines (OPTIMUS)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable electricity generation
Action type: Collaborative project
Countries involved: United Kingdom,United Kingdom,Portugal,Spain,Spain,United Kingdom,United Kingdom,Greece,Spain,Spain,United Kingdom,Cyprus,Belgium
Call:  (FP7-ENERGY-2012-2, 2012)
Start date: 2013-08-01
End date: 2016-07-31
Duration (months): 36.0
Total project cost (EUR): 5636842.58
EU funding (EUR): 3333275.0
Participants: 14
Project status: CLOSED

The power output from wind turbines has increased dramatically over the past thirty years from 50 kW to 6 MW, while 8-12 MW turbines are in the stage of design. State-of-the-art condition monitoring systems, such as vibration-based systems and temperature sensors, are able to monitor and evaluate the current condition of components of interest. Nonetheless, varying wind loads can result in the generation of false alarms or even misinterpretation of the data collected. In addition, commercially available condition monitoring systems offer no or very limited prognostics capability with regards to the remaining lifetime of a component before a serious fault occurs. Therefore evolution to predictive maintenance strategies is currently impossible. Experience has shown that by combining disparate data sources wind farm operators will be able to move from common reactive maintenance approach to a more cost effective risk-based operation and maintenance strategy with a high level of predictive maintenance scheduling. OPTIMUS will develop and demonstrate in the field novel methods and tools for prognosis of the remaining lifetime of key components based on data acquired by a cost-effective wind turbine condition monitoring system implemented by custom-designed dependable computing systems. This technology will reduce the total cost of energy and advance the deployment of large scale offshore and onshore wind energy by increasing availability and reducing downtime due to unplanned maintenance. Predictive maintenance will also reduce costs incurred from secondary damage to components and enable maintenance activities (and the associated costs) to be optimized with respect to forecast revenue from power generation. The results of this project will lead to a significant step-change over the current capability of commercial condition monitoring systems.

Keywords: wind energy,wind turbine,reliability,prognosis,predictive maintenance,fault tree analysis,condition monitoring,failure analysis,life cycle costs,dependable computing systems
Integrative biology of T cells and dendritic cells in vivo. (INTEGRATE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: France
Call:  (ERC-2012-ADG_20120314, 2012)
Start date: 2013-07-01
End date: 2018-06-30
Duration (months): 60.0
Total project cost (EUR): 2499439.0
EU funding (EUR): 2499439.0
Participants: 1
Project status: CLOSED

T cells probe the surface of dendritic cells (DCs) in search of cues reflecting the antigenic and the inflammatory status of the body tissues. The INTEGRATE project aims at using innovative genetic and proteomic tools to describe under physiological conditions and at the systemic levels the molecular signals that results from the encounter of T cells and DCs and that are at the basis of adaptive immunity. This project is based on a constellation of pilot experiments that support its feasibility. It will capitalize on 15 novel lines of knockin mice that will allow us to generate via Mass Spectrometry a high-density set of quantitative data describing the TCR signaling network of primary CD4+ and CD8+ T cells and of Foxp3+ regulatory T cells. INTEGRATE will also include innovative genetic approaches to analyze the T-cell intrinsic regulatory mechanisms that terminate T cell activation and the malfunctions of which are at the basis of inflammation and autoimmunity. Since the study of DCs is mandatory if we are ever to make sense of the complexity of T cell activation, a segment of the INTEGRATE project will be devoted to disentangle the function of key DC subsets in vivo. Four aims will be addressed using multidisciplinary approaches: AIM 1: Defining via MS the composition and dynamics of the signaling complexes that assemble around 17 nodes of the TCR signaling cascade of primary CD4+ and CD8+ T cells and in regulatory T cells. AIM 2: Determining how mutations that reduce TCR signaling output paradoxically lead to autoimmune pathologies. AIM 3: Disentangling the function of dendritic cell subsets in vivo using innovative genetic tools. AIM 4: Integrating the T cell- and the DC-side and defining the masterswitch(s) between tolerance and immunity. It is thus expected that the INTEGRATE project will permit to understand at the system levels the flow of information in T cells stimulated under physiological conditions by well-defined subsets of DCs.

Keywords: t cells,dendritic cells,immunity,tolerance,autoimmunity,allergy,proteomics,knockin mice.
Atomic Gyroscope for Enhanced Navigation (AGEN)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Aeronautics and air transport
Action type: Collaborative project
Countries involved: Switzerland,France,Portugal
Call:  (FP7-AAT-2012-RTD-L0, 2012)
Start date: 2012-12-01
End date: 2014-10-31
Duration (months): 23.0
Total project cost (EUR): 759246.0
EU funding (EUR): 599545.0
Participants: 3
Project status: CLOSED

Aircraft navigation and safety in the absence of GPS/Galileo signals can be improved by higher performances Inertial Measurement Units (IMU) and thus by higher performances gyroscopes. The “Atomic Gyroscope for Enhanced Navigation (AGEN)” project aims at showing the feasibility of the development of such an inertial grade gyroscope for aircraft navigation and delivering higher performances than Ring Laser Gyroscopes while having small dimensions and power consumption. Atom (atomic) gyroscopes hold the promise of reaching even better performances, but their state of development is presently in the “research” stage and user’s requirements in terms of size, power consumption, cost and performances will be analyzed and targeted. Such a development may open up new application fields such as unmanned commercial flight, enhanced navigation for UAVs, enhanced marine, sub-marine and Unmanned Surface Vehicle navigation. A conceptual design will be performed, allowing the trade-off between various concepts. Laboratory tests will be restrained to validating the gas cell, the heart of an atomic gyroscope, showing the feasibility of such a concept. This development will bring redundancy and will enhance the robustness of guiding systems relying on Galileo.. Finally, an assessment and a roadmap of the future development steps will be performed.

Keywords: gyroscope,navigation,atomic gyroscope,nuclear magnetic resonance,long-term stability.data fusion