Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Scalable Qubit Readout to Resolve Superconducting Quantum Computing’s Skeleton in the Closet (SQELETON)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: Transition Open 2024 (HORIZON-EIC-2024-TRANSITION-01, 2024)
Start date: 2025-05-01
End date: 2027-10-31
Duration (months): 30.0
Total project cost (EUR): 3542243.21
EU funding (EUR): 2479570.25
Participants: 1
Project status: SIGNED

The field of quantum computing faces a critical bottleneck as quantum processors scale beyond 100 qubits: the challenge of high-fidelity qubit readout described as superconducting quantum computing's “skeleton in the closet”. Present readout technologies struggle with noise, bandwidth limitations, and complex cryogenic setups, hindering the path to practical quantum computers. Silent Waves addresses this challenge through a breakthrough technology developed within the TruePA project. Our Traveling Wave Parametric Amplifier and Isolator (TWPAI) offers a revolutionary solution, combining quantum-limited amplification and built-in isolation in a single, compact device. Our TWPAI is a significant leap beyond current state-of-the-art, achieving 20 dB gain and 30 dB isolation with noise performance approaching the standard quantum limit. Importantly, by integrating amplification and isolation functions, we eliminate the need for bulky, magnetically-active individual components, paving the way for scalable quantum processors with thousands of qubits. This project uses well-defined plans to advance our TWPAI to TRL6, focusing on performance optimization, on-chip integration, and system-level validation with commercial quantum processors, showcasing our product to potential customers & key industry players. Our innovation promises to accelerate Europe's quantum computing capabilities, supporting the EU's goal of achieving quantum advantage by 2030. EIC support will accelerate the translation of our cutting-edge research towards a commercial qubit readout product critical to European leadership in quantum technologies, ensuring strategic autonomy in this strategically important field and helping unlock the many transformative applications of quantum computing.

Keywords: quantum computing quantum limited amplification qubit readout traveling wave parametric amplifier superconducting circuits
Understanding the melting dynamics in turbulent flows (MELTDYN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-05-01
End date: 2027-08-31
Duration (months): 64.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Dissolving, eroding, and melting processes are ubiquitous in everyday life, nature, science, and technology. The challenge is to accurately predict the melting or dissolution rate e.g. of an iceberg or glacier---relevant for climate change---or of solid reactants in chemical reactors, important to accurately control reaction rates and temperatures. Current predictions for the melting of glaciers are often off by a factor of 100, and different melting models show inconsistencies. No general consensus of the cryospheric modeling has been reached yet. The difficulties in describing melting and dissolution stem from the multiscale nature of these processes (micrometers to kilometers) and the interaction between thermal, solutal, and viscous boundary layers and their complex interplay with the continuously reshaping boundary. A common belief is that melting always smooths the shape. However, from examples in nature and from theoretical analysis, it is clear that flows around melting or dissolving objects can create a rough (dimpled) surface, dramatically increasing the difficulty of accurate predictions. The objective of the project is to solve the gap in understanding and develop a quantitative understanding of the heat and mass transfer and the resulting melting and dissolution dynamics of fixed surfaces and freely-moving objects in turbulent flows from a fundamental fluid dynamics perspective. To do so, we will perform highly controlled lab experiments and numerical simulations, which allow for a combined experimental, numerical, and theoretical approach to reveal the underlying mechanisms of the melting and dissolution dynamics. Unique experimental flow facilities, the latest 3D optical measurements techniques, and advanced high-performance numerical schemes will allow for a one-to-one comparison between experiments and simulations. Given the societal relevance of climate change and the burning technol

Keywords: turbulence,phase change,fluid dynamics
Exploring Lithium Tantalate on Insulator for functional optical metasurfaces (ELLIPTIC-HOP-ON)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Norway,Greece
Call: Hop-on facility (HORIZON-WIDERA-2025-03, 2025)
Duration (months): 18.0
Total project cost (EUR): 600000.0
EU funding (EUR): 600000.0
Participants: 2
Project status: CLOSED

Transparent ferroelectric oxides with strong second-order nonlinearity are essential platforms for electro-optical and nonlinear photonics linking electromagnetic waves from DC to optical frequencies. Thin-film ferroelectrics such as smart-cut lithium niobate have revolutionized integrated photonics, yet still face hurdles in power efficiency, and volume manufacturability. The ELLIPTIC project addresses these limitations through Lithium Tantalate-on-Insulator (LTOI), a platform offering compatibility with large-scale microelectronic manufacturing, already proven in 5G filters with superior optical properties including high optical damage threshold, reduced photorefractive effects, and low birefringence. Building on this, ELLIPTIC-HOP-ON extends LTOI beyond integrated circuits to functional optical metasurfaces (MSs) for free space optical systems. Exploiting LTOI’s high χ(2) nonlinearity and strong Pockels effect, we target efficient nonlinear frequency generation (e.g. entangled photon pairs via SPDC, THz emission via DFG) and tunable dispersive/diffractive flat optics with dynamic wavefront control. Additionally, phonon-polariton resonances at THz frequencies enable extreme light confinement and ultra-sharp responses. By integrating NHRF’s expertise in metasurface physics with the mature LTOI platform, the project will establish LTOI as a cost-effective, CMOS-compatible technology for next-generation integrated and free-space photonic devices, spanning communications, metrology, and quantum technologies.

Keywords: metasurface,meta optics,
Deconstructing Hypothalamic Neurocircuitry Architecture and Function in Metabolic Control during Health and Disease (HYPOMETAB)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Understanding the exact nature of CNS-dependent regulation of body weight has become of utmost societal importance as we are witnessing an ever-increasing number of overweight and obese subjects who exhibit a predisposition for a plethora of obesity-associated diseases such as type 2 diabetes mellitus, cardiovascular diseases, and certain types of cancers. However, despite the tremendous advances made in defining the neurocircuitry basis underlying the central control of feeding and metabolism, critical open questions still remain. For example, how can we reliably identify the exact anatomical localization of the recently identified molecularly heterogenous cell types in the hypothalamus? What are yet unknown energy state- or food cue-regulated neuronal cell types and what is their functional contribution to energy homeostasis? Which are yet unidentified neurocircuits critical for the initiation of adverse metabolic effects upon highly palatable food consumption? And what are the lipotoxic species accumulating in energy state-regulated neuronal cell types upon obesity development? The proposed work program will employ state-of-the-art technologies in modern molecular systems neuroscience and mouse genetics and will focus on the following four key aims: 1. Establishment of a high-resolution spatial transcriptional map of the murine hypothalamus 2. Identification, validation, and functional characterization of novel hypothalamic neuronal cell types activated during fasting/feeding transitions and upon sensory food perception 3. Discovery of novel hypothalamic neurocircuits activated during obesity development 4. Assessment of cell-intrinsic lipidomic changes in metabolism regulatory neurons during obesity development Thus, the proposed work program will not only advance our fundamental understanding of the CNS-dependent regulation of metabolism, but could also open up new channels of drug discovery for tackling obesity and obesity-associated metabolic diseases.

Keywords: feeding behaviour,glucose metabolism,hypothalamic neurocircuits,spatial transcriptomics,neurocircuitry mapping,single nucleus rna sequencing,innovative transgenic mouse models
Development of an immune-armed therapeutic adenoviral platform for pediatric brain tumors (POPCORN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-05-01
End date: 2026-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Diffuse Midline Gliomas (DMGs) are the most aggressive pediatric brain tumors in desperate need of curative treatment. The median life expectancy of these children remains below 14 months after diagnosis, and nearly none survive beyond the second year. Similarly, for other high-risk pediatric brain tumors, there is hardly any option after recurrence, and long-term survivors are faced with life-long sequelae that impact their quality of life. In this scenario, there is an urgent need for innovative, efficacious, and safe therapies for these patients. Oncolytic viruses are promising anticancer biotherapeutic agents that offer a unique combination of safety profile, direct antineoplastic activity, and the induction of anti-tumor immune responses. Recently, a Phase I clinical trial showed that combining the oncolytic adenovirus Delta-24-RGD and radiotherapy is non-toxic and results in anti-tumor responses and prolonged median overall survival (17.8 months) in patients. However, results are still insufficient to be curative due to counteracting mechanisms intrinsic to the tumor microenvironment and also triggered by the virus that eventually exceeds its immunostimulatory properties. The proposed technology, termed “POPCORN”', is an oncolytic-based platform capable of expressing immunomodulatory single-domain antibodies directed to intrinsic targets in these tumors. We will develop the POPCORN Proof of Concept using a state-of-the-art experimental approach and validate its safety and efficacy in vitro and relevant in vivo DMG models. We will also perform IND-enabling studies and apply for PUMA/PRIME designation. Additionally, we will work on the IPR strategy, and a value proposition to develop and commercialize the POPCORN platform will be generated. We envision the POPCORN platform becoming a game changer in treating DMGs, providing a one-of-a-kind tool for eliminating these aggressive tumors that could be extensive to other difficult-to-treat pediatric brain tumors.

Keywords: pediatric brain tumors,diffuse midline gliomas,high risk pediatric brain tumors,advanced therapies,oncolytic viruses
TOMAC: Bioinspired Flow Generation in Tubeless Organ-on-a-chip using Magnetic Artificial Cilia (TOMAC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-04-01
End date: 2025-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Currently, 90% of the drugs fail to pass clinical trials1. One of the key reasons is that the animal models used in the preclinical phase poorly predict the human response to the drugs. Organ-on-a-Chip (OoC) is a game changing technology as one of the alternative methodolgies to animal models. The heart of an OoC system is an ‘Organ-chip’: cm-sized devices with micro-channels and -chambers in which human cells can be grown to closely mimic human tissues. More and more evidence shows that OoCs are more representative models than animals. However, the industry adoption of OoCs is still very limited. OoC users and developers simply have to choose between either OoCs with physiologically relevant flow but not fit for standard operating procedures in the pharmaceutical industry, or OoCs that are compatible but less physiological because of the absence or inadequacy of the flow. The TOMAC project offer s novel a solution called “Magnetic Artificial Cilia (MAC) pump”: a chip-sized modular and tubeless flow system that on one hand, eliminates manual handling and enables automation, and on the other hand provides physiological flow for a range of organ models. The technology behind MAC is based on micrometer-sized magnetic hair-like structures called Magnetic Artificial Cilia (MAC), which are inspired by cilia occurring in nature. The MAC are flexible micro-actuators that respond to a varying magnetic field (created by the actuation system) by rotating or oscillating, and thus create a controlled fluid flow.
NEW STRATEGIES FOR THE EARLY DIAGNOSIS, RISK STRATIFICATION AND CO-MANAGEMENT OF FAMILIAL HYPERCHOLESTEROLEMIA (FH-EARLY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Portugal,Spain,Finland,Netherlands,Romania,Czechia,Lebanon,France,Türkiye
Call: Tackling high-burden for patients, under-researched medical conditions (HORIZON-HLTH-2024-DISEASE-03-two-stage, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 7702548.96
EU funding (EUR): 7286252.25
Participants: 15
Project status: SIGNED

Familial hypercholesterolemia (FH) is the most common inherited metabolic disorder in the world with about 2.5 million Europeans affected. An accurate diagnosis through genetic testing confirms the disorder in only about 50% of the cases. Different effective treatments to reduce cardiovascular disease exist; however these high-risk individuals are not being clinically identified. FH-EARLY will enable new strategies for earlier diagnosis and co-management of familial hypercholesterolemia facilitated by well-defined data flows, identifying new mechanisms through multiomics, explainable AI modelling and co-creation with families with FH and caregivers. Its specific objectives are: 1. Use co-creation methods to involve FH patients, families and care teams during the project. 2. Enhance 4 federated multi-modal datasets collated from established cohorts, and realworld datasets. 3. Conduct large-scale functional characterization of FH-related gene variants, to illuminate affected protein function and the variability of the FH phenotype 4. Develop and test an integrative precision health profiling methodology using explainable AI for FH risk prediction. 5. Test and validate a new chip array for early diagnosis 6. Establish clinical and health economic benefits for the signature biomarker in a multicenter interventional study for FH screening. 7. Integrate the early signature biomarker into clinical practice to improve treatment selection and risk assessment of FH and severe hypercholesterolemia patients FH-EARLY will deliver a chip array for earlier, cheaper diagnosis, a signature biomarker assay for unique risk stratification and a XAI driven integrative precision health profiling tool. These will help reduce the burden of atherosclerotic cardiovascular disease, while shifting towards a holistic co-management approach including healthier living in families with FH. This will have a significant impact on cardiovascular health for families with FH and the wider population

Keywords: early diagnosis,explainable ai,chip array,biomarker assay,co creation,cardiovascular health,genetic counseling,familial hypercholesterolemia,innovation,multiomics
Redefining the role of mixing in ocean overturning and ventilation (REMIX-TUNE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 2997166.0
EU funding (EUR): 2997166.0
Participants: 2
Project status: SIGNED

Turbulent mixing controls the pace of ocean ventilation, the rate at which the ocean interior is filled up with water, heat and chemicals from the ocean’s surface. This process governs the ocean's ability to store atmospheric heat and greenhouse gases, exerting a profound impact on Earth's climate and moderating the rate of human-induced climate change. However, the role of mixing in ocean ventilation remains poorly understood, due to the scarcity of direct observations and the inability of numerical models to capture small-scale turbulent dynamics. Our limited understanding can be rationalised around three major questions: 1) How does the interplay between advective and diffusive processes control ocean ventilation? 2) What is the role of mixing in the water-mass transformations sustaining the ocean’s overturning circulation? 3) What is the relative importance of the two primary regimes of ocean turbulence (the mesoscale and microscale) for the ventilation of climate-critical tracers? REMIX-TUNE addresses these questions through an innovative approach founded on two pillars: 1) Deploying the first large fleet of autonomous profiling floats equipped with microstructure turbulence sensors in key ocean ventilation regions; and 2) pioneering a novel theoretical approach to quantify mesoscale and microscale mixing using float microstructure observations and existing hydrographic data from the Argo programme. With this strategy, REMIX-TUNE will generate the first comprehensive, observation-based global database quantifying the role of mixing in ocean ventilation. This understanding will then be used to develop a new framework to assess and ground-truth the representation of mixing in the next generation of ocean-climate models. Thus, REMIX-TUNE will elicit a step change in our rationalisation of ocean mixing, and its integration into numerical models, and will leave a lasting impact on mixing research by revolutionising the methodologies employed in the field.

Keywords: ocean circulation and climate,ocean mixing,ocean technology
Securely Advancing Future EVs with Li-IOn batteries through Optimized Pathways (SAFELOOP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Finland,Germany,Poland,Ukraine,France,Türkiye,Greece,United States,Australia,United Kingdom,Denmark
Call: New Approaches to Develop Enhanced Safety Materials for Gen 3 Li-Ion Batteries for Mobility Applications (Batt4EU Partnership) (HORIZON-CL5-2023-D2-02, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 4749117.5
EU funding (EUR): 4749117.5
Participants: 15
Project status: SIGNED

Envisioned battery demand of 735 GWh for electric mobility by 2025, escalating to a projected 125 million Electric Vehicles (EVs) by 2033, fuels our impetus for innovation. However, these prospects are marred by real safety concerns, evidenced by 2 harrowing ship fires involving luxury EVs, despite adherence to the most stringent safety protocols. SAFELOOP is a collaborative effort involving 15 entities from 11 countries, representing a blend of research, manufacturing, and business across Europe. Transatlantic partners are joining forces to bolster competitive material-level technologies and supply chain logistics. Key goals include securing strategic raw material feedstock, reducing reliance on Asian supply chains, intensifying environmental sustainability, optimizing energy-efficient processing, and demonstrating technological leadership. SAFELOOP’s focal point is Gen3 EU EV Li-Ion Battery (LIB) safety, encompassing the entire life cycle of LIBs within EVs. Safety is considered in a broader sense, not just at a cell level, while the latter remains a key pillar of the research at hand. To name a few, material handling, component processing, battery manufacturing, testing, transport, maintenance, and recycling of active materials are considered. A Eurocentric supply chain for EV-grade battery materials will be established, minimizing the environmental and cost impact of long-distance transportation. SAFELOOP ensures that batteries and their components adhere to EU safety and environmental regulations. Beyond enhancing EU battery safety, the project seeks to develop the world's first EV-rated LIB using up to 25% recycled and fully rejuvenated battery-active materials. This initiative paves the way for an ambitious industry-wide recycling target of 90% within the next decade, akin to today's lead-acid battery industry's 95% recycling rate. These ecologically responsible solutions address key aspects of automotive battery safety within the EU and beyond.

Keywords: safety challenges,material level technologies,eurocentric,recycling,evs