Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Digital Marketplace to empower SMEs for the digital transformation (UDIGITAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Digital Transformation is the complete transition of the business activities of a company to the digital realm. Thus, during 2017, over 80% of enterprises spent an average of 44% of their IT budget in their digital transformation. However, 84% of companies fail at this challenge since the current approach to digital application development is expensive, complex, time-consuming and fragile. On top of that, SMEs also face budget constraints, legacy system issues, and limited availability of skilled employees. But UGROUND, due to the use of semantic engineering, has created a high productivity platform- patented in the USA- that provides total flexibility and enables SMEs to innovate very quickly and at a low cost. UDIGITAL is its cloud environment, where integrators will have access to our semantic engine (which interprets and proccess human knowledge), and to several different business model framework for each target market, addressing the specific needs of SMEs in those niches. Key straightforward benefits of our solution are: increase company competitiveness, including a 400% reduction of the development costs % (operation and programming times) and up to a 60% of the development effort (man hours and programming skills). As a result, the digital transformation investment ROI is less than one year. As it has been proved in our current clients our technology is able to increase over 99.5% the operational efficiency, and reduce up to 350,000 man hours. UDIGITAL is focused in supporting SMEs, which have an actual problem at digital transformation due to lack of internal expertise or limited resources to buy expensive platforms. Through this project, we aimto reach over 4000 clients, targeting sectors such as legal and consultancy services, manufacturing, human resources and construction (our primary markets) in 3 years, generating revenues of €300M by 2022.

Keywords: digital transformation,semantic engineering,platform,marketplace,human knowledge,productivity,competitiveness,no code
Building the Future: Excelling in Computational and Quantitative Social Sciences in Turkey (Social ComQuant)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Italy,Türkiye
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2020-08-01
End date: 2023-07-31
Duration (months): 36.0
Total project cost (EUR): 898840.0
EU funding (EUR): 898840.0
Participants: 3
Project status: SIGNED

Digitalization of society characterizes the twenty-first century in many aspects of social, political and cultural life. Computational Social Science (CSS) and Quantitative Social Science (QSS) methods have rapidly developed to analyse these digital human traces, and have become the indispensable core of current high impact scientific research in Social Sciences. However, the widening country Turkey severely lacks scientific expertise and capacity in these methods. Therefore, the Koç University (KU) in Istanbul has teamed up with GESIS- Leibniz Institute for the Social Sciences from Germany and ISI Foundation- Istituto Interscambio Scientifico (ISI) from Italy to form the project consortium Social ComQuant. The leading institutions GESIS and ISI will share their expertise in CSS and QSS and facilitate to build scientific excellence at KU in these fields. The project will (i) train early stage researchers at KU in CSS and QSS; (ii) increase scientific excellence of faculty members at KU and other Turkish institutions in CSS and QSS; (iii) build a teaching infrastructure for academic curricula in CSS and QSS at KU; and (iv) strengthen joint research collaboration between the consortium members. These objectives will be reached through staff exchanges, summer schools, workshops, expert visits and a virtual training platform that will establish a significant human capacity at KU by facilitating faculty members, graduate and undergraduate students to gain utmost experience in CSS and QSS. This will transform the widening institute KU to a regional hub in Turkey and the wider Middle East region for sociology research on digitalization and big data. Social ComQuant will fulfil the objectives of the Twinning Actions by introducing the promising institute Koç University into the closed group of excellent EU institutes in Social Sciences, increasing the participation of Turkey in European projects and establishing Turkey as an equal partner of the European Research Area.

Keywords: computational social sciences,quantitative social sciences,social science methodology,social science,computer science
SUSTAINablility increase of lightweight, multifunctional and intelligent airframe and engine parts (SUSTAINair)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Austria,Austria,Germany,Austria,Austria,Germany,Austria,Belgium,Netherlands,Netherlands,Netherlands,Netherlands
Call: Next generation multifunctional and intelligent airframe and engine parts, with emphasis on manufacturing, maintenance and recycling (H2020-MG-2020-SingleStage-INEA, 2020)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 4843863.33
EU funding (EUR): 4843863.33
Participants: 12
Project status: SIGNED

Multiple challenges exist with respect to the development of multifunctional and intelligent airframe and engine parts. These are situated along the entire aircraft component value chain - design, manufacturing, MRO and recycling. SUSTAINair addresses each of these phases. With respect to design, new joining techniques for metal and composite designs are developed and demonstrated. For metal joining, these include a novel pin-pattern creation with Laser Powder Bed Fusion/Wire Arc Additive Manufacturing/Laser Direct Energy Deposition. For composites, these consist of thermoplastic welding. With respect to both design and manufacturing, a flexible wing with morphing capabilities is made industrially possible by introducing a novel concept using tailored elastomers, seamless integrated with conventional structural wing parts for lowest integration risk, providing a realistic industrial morphing technology. The problem of high production waste in the manufacture of composite materials, Ti AM and Al HPDC is addressed, thereby reducing waste streams, e.g.: For thermoset prepreg manufacturing waste and thermoplastic waste, new recycled materials are developed and characterized to allow re-use with recyclability up to 100%, bringing FTB ratio close to 1 (KET3-KPI); Increased BTF ratio of Ti powders by using it 6x (vs. 1x now) (KET4-KPI); Incredible BTF ratio <1.1 by advanced HPDC processing of thermal stable nano-eutectics (KET5-KPI). A Structural Health Monitoring system optimizing MRO activity is proven using radically new ZnO nanowires, which will be integrated into polymer as well as metal parts. Finally, SUSTAINair raises the bar with respect to aircraft EoL, introducing Industry 4.0 automated technology for robotic dismantling.

Keywords: design,additive manufacturing,recycling,novel pin joints,thermoplastic welding,morphing wing,casting hpdc,eol dismantling,industry 4 0,reduced btf,metallurgy,composite
Investigating how pathogen effector recognition by the host plant activates cell death (HRPCDMECH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-02-01
End date: 2018-01-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Plants are rich sources of nutrients and water for diverse microbial communities. Some of these communities evolved parasitism as a strategy to access plant nutrients, with devastating results for crops. Plants are protected from infection by a waxy cuticular layer above the walls of epidermal cells. Would-be pathogens breaching this barrier, or entering via stomata, encounter an active plant immune system that specifically recognizes pathogens. Breaching leads to the deployment of two synergistic pathways that orchestrate immune responses. The first relies on the detection of pathogen-associated molecular patterns (PAMPs) and culminates in pattern-triggered immunity (PTI). When the first is circumvented a second array of responses takes place known as effector triggered immunity (ETI). In ETI, host factors known as R proteins recognize pathogen effectors, an event which is accompanied by the execution of a unique programmed cell death (PCD) type known as the hypersensitive response (HR). Although the initiator of the HR-PCD is known to depend on the formation of an effector-R complex, the downstream molecular events remain elusive. Previous results showed that particular proteases known as metacaspases (MCs) modulate HR-PCD, highlighting the importance of proteolysis and proteome rearrangements for HR-PCD modulation. I will attempt to shed light on the rearrangements of the HR-PCD proteome landscape, by studying processes that control it: selective RNA decapping and translation and proteolytic events, in a highly temporal manner using systematic approaches and reverse genetics. This project is expected to elucidate the importance of these processes and provide a detailed analysis of mRNA and protein level rearrangements during HR-PCD. In addition, this project will suggest strategies for enhancement of plant immunity against pathogens, which is urgently needed to sustain food security considering the ever growing earth’s population.

Keywords: cell death,stress biology,plant microbes interactions,transcriptomics,proteomics
Quantum Effects in Multicolor Ultrafast Laser Processing: Broadening Boundaries of Classical Descriptions (QuantumLaP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Czechia
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 142720.8
EU funding (EUR): 142720.8
Participants: 1
Project status: CLOSED

In this project the interaction of ultrashort laser pulses with semiconductor materials will be investigated on a principally new level by taking into account quantum effects that can emerge in highly-excited non-equilibrium matter. The central goal is to study bi-chromatic irradiation regimes which have been found to be extremely effective, compared to monochromatic laser beams, for various applications from micro-/nanostructuring of surfaces to nanoparticle generation and film deposition. This topic will be addressed through the development of a new powerful large-scale 3D model of laser-matter interaction. For the first time two modeling approaches will be combined, electronic structure theory and classical electrodynamics. Necessary steps to achieve these goals are: • Making an existing classical FDTD model to be self-consistent via introducing feedback to the laser field from the swiftly evolving free electron population; • Extending the model to the large scale 3D domain to account for realistic response of materials to polarized laser light; • Modelling of the action of bi-chromatic laser light on semiconductors at the quantum level based on the time-dependent density functional theory (TDDFT); developing a theory of photo-ionization of materials by mixed laser wavelengths; • Bridging classical large-scale simulations of ultrashort pulse excitation of semiconductors with quantum peculiarities of photo-ionization. The key goal of the project is to demonstrate the power of the developed model in predicting the morphology of functionalized surfaces for materials of various properties under new irradiation conditions in collaboration with experimentalists at HiLASE. By providing in-depth understanding of underlying physics, this work will open the way to achieve the control over functionalization of semiconductor surfaces, thus, pushing this field away from empirical methods to a smart computer-predicted technique.

Keywords: ultrashort laser matter interaction,bi chromatic laser processing,semiconductors,large scale simulations,quantum modeling,nanostructures,photonics
Carabids as biocontrol agents for slugs in Oregon and Ireland - a novel and interdisciplinary approach to determine key malacophagous species and beneficial management options (CaraSlug)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Ireland,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2020-09-30
Duration (months): 36.0
Total project cost (EUR): 248063.4
EU funding (EUR): 248063.4
Participants: 2
Project status: CLOSED

One of the challenges identified under Horizon 2020 is the building of a sustainable agri-food industry. Agricultural pests such as slugs are major contributors to financial losses in the farming sector and the use of pesticides, which is currently the mainstay of control, is an unsustainable management option due to their toxicity to non-target species and consumers but also because of their cost and variable efficacy. Biocontrol poses a more sustainable approach to pest control, but the only commercially available agent against slugs is the nematode Phasmarhabditis hermaphrodita which is ineffective against a number of key pest species, has a short shell life and is not permitted in countries outside of Europe (e.g. USA). CaraSlug aims to assess the potential of native carabid species as biocontrol agents against slug pests in Oregon and Ireland. For the first time, high-throughput sequencing and real-time PCR will be used in combination to analyse the gut contents of carabids collected over one year from vulnerable crops. Carabid species which are found to feed extensively on slugs and are abundant in crops at times when major slug damage occurs will be selected for feeding trials in the laboratory to further understand their feeding behaviour and biocontrol potential. By comparing the abundance of both pest and predator species and by determining the availability of alternative prey in differently managed crops e.g. with and without beetle banks over a year, management systems which provide optimum conditions for malacophagous carabid species will be identified. This project is interdisciplinary, combining ‘classic’ ecology and environmental management approaches with the latest advances in molecular biology and both the experienced researcher and the hosts will benefit greatly from the combined team’s expertise. By directly involving farmers in our research, this project will also form an important link between academia and the community.

Keywords: pest slugs,carabids,molecular gut content analysis,beetle bank,alternative invertebrate prey,feeding trials
Mechanical regulation of cellular behaviour in 3D viscoelastic materials (MECHANOSITY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2022-08-31
Duration (months): 36.0
Total project cost (EUR): 239191.2
EU funding (EUR): 239191.2
Participants: 2
Project status: CLOSED

Extracellular matrix (ECM) mechanical properties have emerged as key promoters of processes such as cell migration and epithelial to mesenchymal transition (EMT) in cancer. Despite recent advances in the understanding of cellular ECM sensing machinery, mimicking tissue microenvironments in vitro is highly challenging, and most research has been focused on two dimensional (2D) elastic substrates. However, ECMs are not merely 2D elastic substrates, but rather viscoelastic three dimensional (3D) materials. Our objective is to understand how the viscoelastic properties of 3D ECMs regulate cell behaviour. We hypothesize that in viscoelastic materials, counter-intuitively, an increase in viscosity triggers force transduction and gene expression, due to an increase in the load of molecular clutches formed between the ECM and actin. To address the influence of viscoelasticity, Alberto Elosegui-Artola (the experienced researcher/ Applicant) will develop a set of hydrogels matching the viscoelastic properties of both healthy and malignant breast tissue. Then, traction force microscopy will be developed and combined with molecular biology techniques to determine the molecules involved in 3D viscoelasticity sensing. The dynamic behaviour of these molecules will be integrated in a 3D molecular clutch model with the aim to predict cellular migration and force transduction. Model predictions will be validated by performing experiments in 3D viscoelastic gradients on the migration of single cells and spheroids. Lastly, the relevance of the model will be tested by observing if impairing model-predicted force transduction elements prevents EMT transition in cell lines and mouse-derived breast healthy and tumour organoids. This project’s results are expected to reveal molecular interactions that could lead to new therapeutic targets in breast cancer, and also to provide translational opportunities in other disciplines including biomaterials and regenerative medicine.

Keywords: mechanobiology,mechanotransduction,biomaterials,molecular clutch,extracellular matrix,focal adhesions,viscoelasticity,traction force microscopy
RAPID MIGRAINE RELIEF WITH ALGINATE-BASED THIN FILM (RAPID)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-11-01
End date: 2021-06-30
Duration (months): 32.0
Total project cost (EUR): 2902248.75
EU funding (EUR): 2031574.13
Participants: 1
Project status: CLOSED

Klaria's business concept is based on developing and commercializing innovative, fast-acting medicinal products with clear competitive benefits in the therapeutic fields of migraine and cancer-related pain. Migraine is the sixth most disabling illness in the world. The economic burden of migraine predominantly falls on patients and their employers in the form of bedridden days and lost productivity. The illness is three times as common in women than in men. However, existing drug delivery methods are not effective which results in low therapy satisfaction rates amongst migraine patients. Klaria developed an alginate-based polymer film capable of rapidly delivering the API (active pharmaceutical ingredient) directly into the bloodstream. The thin film is similar to a small postage stamp and is discreetly attached to the oral mucous membrane and allows the medication to be distributed into the bloodstream through the oral mucous membrane. The substance is delivered much more quickly (and thereby has a faster impact) than substances which are swallowed in tablets or capsules. Klaria’s film does not require taking an injection or suppository and ensures early intervention which is critical in order for migraine patients to experience pain relief. The film can be used by all migraine patients using medications based on triptans including those who experience concomitant vomiting during their migraine attack. Project RAPID, aims therefore to exploit the positive clinical performance of the buccal adhesive film, the company’s IP position and its ability to manufacture cost-effectively to launch an innovative migraine to contribute to an improved quality of life for migraine patients.

Keywords: migraine,headache,sumatriptan,compliance,drug delivery,thin film,alginate,quality of life
Homomorphic Secret Sharing: Secure Computation and Beyond (HSS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2026-05-31
Duration (months): 76.0
Total project cost (EUR): 1490917.5
EU funding (EUR): 1490917.5
Participants: 1
Project status: SIGNED

Secure computation is a powerful cryptographic tool that enables distrusting parties to jointly emulate the correctness and privacy guarantees of an incorruptible trusted third party. The past decades have seen tremendous progress in secure computation protocol design, yet there remain significant gaps in our understanding. On one hand, "classical" approaches require excessive communication between parties; on the other hand, approaches based on fully homomorphic encryption (FHE) require heavy computation as well as significant concrete communication costs. These shortcomings are particularly limiting as the scale of secure computations grows to match the modern regime of big data. The central objective of Project HSS, is to understand and develop the capabilities of secure computation design and surrounding technology via a new methodology of homomorphic secret sharing (HSS). Recently introduced by the PI, HSS is a useful relaxation of FHE where homomorphic evaluation may be distributed across parties who do not interact. Initial results indicate that HSS yields a new paradigm for secure computation with analogous advantages as FHE, while opening the door to simpler, more efficient solutions. HSS-based techniques demonstrate exciting potential also as a means for greatly advancing supporting technologies within all paradigms, and even bridging to other disciplines, with developments and implications reaching beyond the realm of secure computation. The focus of Project HSS will be in exploring these vast new horizons.

Keywords: cryptography,secret sharing,secure computation