Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Monitoring Developments for safe Repository operation and staged closure (MODERN)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Radioactive waste management
Destination: Management of Ultimate Radioactive Waste
Action type: Collaborative project
Countries involved: France,Germany,Spain,Belgium,Switzerland,United Kingdom,Netherlands,Finland,Czechia,United States,Belgium,United Kingdom,Sweden,United Kingdom,Sweden,Japan
Call:  (FP7-Fission-2008, 2008)
Start date: 2009-05-01
End date: 2013-10-31
Duration (months): 54.0
Total project cost (EUR): 5111483.0
EU funding (EUR): 2800000.0
Participants: 18
Project status: CLOSED

The MoDeRn project aims at providing a reference framework for the development and possible implementation of monitoring activities and associated stakeholder engagement during relevant phases of the radioactive waste disposal process, i.e. during site characterisation, construction, operation and staged closure, as well as a post-closure institutional control phase. Monitoring provides operators and other stakeholders with in-situ data on repository evolutions, to contribute to operational safety, to help manage construction, operation and/or closure activities, and may allow for a comparison with prior safety assessments. It thus provides information to inform necessary decisions. If, in addition, monitoring activities respond to stakeholder needs and provide them with understandable results, they will contribute to transparency and possibly to stakeholder confidence in the disposal process. The project is structured into six work packages (WPs). The first four WPs are dedicated to (i) analyze key objectives and propose viable strategies, based on both technical and stakeholder considerations; to (ii) establish the state of the art and provide technical developments to match specific repository requirements; to (iii) conduct in-situ monitoring demonstration experiments using innovative techniques; and to (iv) conduct a case study of monitoring and its integration into staged disposal, including specific scenarii analysis aimed at providing guidance on how to handle and communicate monitoring results, in particular when these provide “unexpected” information. In order to provide a shared international view on how monitoring can be developed within a given national context, WP5 regroups key dissemination activities and WP6 will provide a reference framework integrating project results and describing feasible monitoring activities, suggesting relevant stakeholder engagement activities, and illustrating possible uses of monitoring results for decision-making.

Keywords: reference framework for repository monitoring,monitoring objectives,monitoring strategies,stakeholder engagement,monitoring technologies,monitoring demonstrators,information for decision-making
Europen Nuclear Education Network Training Schemes (ENEN-III)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Support the development of nuclear competences at Union level and socio-economic aspects
Destination: Human Resources and training
Action type: Coordination and support actions
Countries involved: France,Belgium,Belgium,Finland,France,Germany,Hungary,Italy,Netherlands,Romania,Slovenia,Spain,Spain,United Kingdom,Germany
Call:  (FP7-Fission-2008, 2008)
Start date: 2009-05-01
End date: 2013-04-30
Duration (months): 48.0
Total project cost (EUR): 1970508.0
EU funding (EUR): 950000.0
Participants: 20
Project status: CLOSED

The project covers the structuring, organisation, coordination and implementation of training schemes in cooperation with local, national and international training organisations, to provide training to professionals active in nuclear organisations or their contractors and subcontractors. The training schemes provide a portfolio of courses, training sessions, seminars and workshops for continuous learning, for upgrading knowledge and developing skills. The training schemes allow the individual to acquire qualifications and skills, as required by specific positions in the nuclear sector, which will be documented in a training passport. The essence of such passport is to be recognised within the EU by the whole nuclear sector, which provides mobility to the individual looking for employment and an EU wide recruitment field for the nuclear employers. The recognition is subject to qualification and validation of the training courses according to a set of commonly agreed criteria, which can be ratified by law or established on a consensus basis within a network. The training schemes cover profiles for each of the following: - the basic training in selected nuclear topics of non nuclear engineers and personnel of nuclear facilities contractors and subcontractors; - the technical training for the design and construction challenges of GEN III plants, and the design of GEN IV plants. The training schemes consists of three distinct phases: - Courses, seminars, learning, scientific and technical visits, case studies; - Participation to selected activities within the scope of the training in different organisations; - Autonomous conduction of activities within the scope of the training under supervision of a mentor in one or in different organisations The first phase can be provided by universities and training centers, the second and third phases can be provided by industries, research centers and future employers.

Keywords: training,education,power plant,postgraduate,qualifications,skills,mutual recognition
New approaches to the study of membrane-protein folding in vivo and in silico (MEMFOLD)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: Sweden
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-04-01
End date: 2015-03-31
Duration (months): 72.0
Total project cost (EUR): 1999999.2
EU funding (EUR): 1999999.2
Participants: 1
Project status: CLOSED

Membrane proteins are central players in many if not most cellular processes: cell-cell interaction, signal transduction, nerve conduction, small molecule transport, macromolecular trafficking, etc. A growing number of high-resolution membrane protein structures provide important insights not only into function but also into the general structural constraints imposed by the lipid bilayer. In contrast, almost no information is available concerning how membrane proteins fold in vivo. Mainly, this is because of a lack of suitable assays to follow the folding process. The main objective of this proposal is to develop a broad range of new methods, largely based on chemical-biology approaches combined with protein engineering, to study membrane protein insertion, folding, and assembly in vivo or under in vivo-like conditions. We will aim for quantitative studies whenever possible. Questions we will address include: What are the in vivo kinetics of transmembrane-helix integration? What are the energetics of membrane insertion of non-natural amino acid side chains with physico-chemical properties distinct from those of the 20 natural amino acids? What kinds of residue-residue interactions drive interactions between transmembrane helices and between membrane protein subunits? How should we best design and verify novel interacting transmembrane helices? Given the importance of membrane proteins in both basic and applied biological research, we expect that a deeper understanding of the molecular interactions that drive their folding and stabilize their structure in vivo will have a major impact across many areas of molecular life science.

Keywords: membrane proteins,protein folding,protein complexes
Collaborative Project on European Sodium Fast Reactor (CP-ESFR)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Research infrastructure
Destination: Reactor Systems
Action type: Collaborative project
Countries involved: France,United Kingdom,Italy,France,Italy,Spain,Germany,Germany,European organisations area,Netherlands,Czechia,Switzerland,Spain,Latvia,Czechia
Call:  (FP7-Fission-2008, 2008)
Start date: 2009-01-01
End date: 2013-06-30
Duration (months): 54.0
Total project cost (EUR): 11865550.4
EU funding (EUR): 5799931.0
Participants: 24
Project status: CLOSED

The suggested Collaborative Project (CP) addresses key viability and performance issues to support the development of a fourth generation European Sodium Fast Reactor (ESFR). This innovative system is mainly developed for competitive electricity generation and offer interesting potential characteristics in terms of safety, environmental impact, resource utilisation and waste minimisation (e.g. potential for Minor Actinides management). The objectives of the CP-ESFR look for the improvement, vis-à-vis of current nuclear systems, of the safety level, the guarantee of a financial risk comparable to that of the other means of energy production and a flexible and robust management of the nuclear materials. The corresponding technical requirements in terms of System’s performance; Operation, maintenance and procedures; Safety design & analysis and licensing issues; Physical protection &Proliferation resistance; Functional requirements for provisions; Fuel cycle Constructability; Decommisioning; System’s economy are based – among others - upon the results of the 6th FP Specific Support Action EISOFAR (Roadmap for a European Innovative SOdium cooled FAst Reactor). The schedule for this four years project fit with the principle for an industrial deployment of ESFR technology around 2040 with the preliminary deployment of a demonstrator by 2020-2025. Following the requirements above, and considering the context as it is described, the Collaborative Project is tentatively structured into six main technical sub projects (SPs): 1)Consistency and assessment & international relationships 2)Fuel, fuel element, core & fuel cycle 3)Safety and Security 4)Energy Conversion System Components & materials 5)Reactor system (including handling) 6)Education & training A specific Management activity will insure the whole consistency.

Keywords: innovative nuclear systems,sodium fast reactor,generation iv
Long-term synaptic plasticity in interneurons: mechanisms and computational significance (INTERPLASTICITY)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: United Kingdom
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-10-01
End date: 2014-09-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Memory encoding occurs by strengthening or weakening of synapses among principal neurons. However, excitatory synapses on some inhibitory neurons in the hippocampus also exhibit use-dependent long-term potentiation and depression (LTP and LTD), with important consequences for network homeostasis and information processing. This proposal addresses the following areas: 1. Although the rules determining which forms of plasticity occur at which synapses are emerging in the hippocampus, relatively little is known in other parts of the brain involved in cognition, movement initiation and emotion. We will use electrophysiology, optical imaging and mouse genetics to map out the expression of activity-dependent plasticity at excitatory synapses on inhibitory neurons in the cortex, striatum and amygdala, and relate these to the biophysical and pharmacological properties of the neurons and synapses involved. 2. Although one form of interneuron LTP resembles plasticity in pyramidal neurons, another form requires Ca2+-permeable AMPA receptors and metabotropic glutamate receptors for its induction, and shows features suggestive of pre-synaptic expression. A similar dichotomy exists in two forms of LTD, which depend on either NMDA or Ca2+-permeable AMPA and metabotropic glutamate receptors. We will test the involvement of candidate intracellular and trans-synaptic signalling cascades to understand the mechanisms triggered by distinct conjunction patterns of pre- and post-synaptic activity. 3. What is the computational significance of LTP and LTD in interneurons? The elemental computational roles of different GABAergic interneurons and their firing patterns during behaviourally relevant brain states are beginning to emerge. How synaptic strengthening and/or weakening interact with these network functions is however poorly understood. We will address this through a combination of hypothesis-driven experiments and numerical simulations.

Keywords: interneurons,synaptic plasticity,cortex,hippocampus,glutamate receptors
Novel Mechanisms of Airway Inflammation (INFLAMMATORICS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: France
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-07-01
End date: 2010-12-31
Duration (months): 18.0
Total project cost (EUR): 2470400.0
EU funding (EUR): 2470400.0
Participants: 1
Project status: CLOSED

This is a proposal to define a fundamentally new and potentially dominant pathway of airway inflammation involving the p53 homolog p73 acting through regulators of cytokine mRNA stability. We anticipate that the studies described herein will contribute to our understanding of acute and chronic airway diseases and the development of novel therapies to combat them. The proposal is divided into four parts: 1. Establish a Role for p73 in the Innate Immune Response in the Upper Airways Our genetic models for loss of p73 function reveal the unexpected finding that ciliated airway epithelia play a major and perhaps dominant role in airway inflammation. We will exploit genetic and cellular models to establish the broader significance of these cells and of p73 in regulating the innate immune response and how they contribute to human disease. 2. Define the Signaling Pathways of the Innate Immune Response in Airway Epithelia We will use mass spectrometry, shRNA technology, and small molecule inhibitors to dissect these pathways linking p73 to airway inflammation and develop chemical screens as a basis of therapeutic intervention. 3. Determine the Genetic Targets of p73 that Control Airway Inflammation Our preliminary work has identified key regulators of mRNA stability downstream of p73, and has implicated them in the destabilization of inflammatory ytokine mRNAs. These observations suggest a novel mechanism for the control of airway inflammation involving mRNA stability. 4. Mouse Models for Dcp1² Loss-of-Function The identification of Dcp1² as the strongest target of p73 offers a new and fundamental approach to the control of airway inflammation. Genetic models in mice will provide new insights into the role of mRNA stability for airway inflammation and novel models of human airway disease.

Keywords: airway inflammation,p73,cytokines,toll-like receptors,mrna decapping
Towards the Quantal Nature of Receptor/cAMP Signals (TOPAS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: Germany
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-01-01
End date: 2013-12-31
Duration (months): 60.0
Total project cost (EUR): 2493357.6
EU funding (EUR): 2493357.6
Participants: 1
Project status: CLOSED

Most drugs act via cell surface receptors. Some receptors signal to ion channels, while others regulate 2nd messengers, most importantly cAMP. Ion channels can be resolved at the single channel level using patch clamp analysis; they switch between discrete "on" and "off" states. In contrast, current techniques to analyze cAMP-signals are quite global and generally require destruction of the sample. Therefore, the activation mechanisms and switching behaviour of receptors signalling to cAMP are largely unknown. This project postulates minimal quantal cAMP-signals that are triggered by individual receptors. We aim to discover these quantal cAMP-signals, to characterize their temporal and spatial patterns, and to determine factors that influence them. To do so, we will develop a microscopic technology to image cAMP-signals with high sensitivity and resolution. We have already developed a first generation of cAMP-sensors that can be expressed in cells and respond to cAMP with a change in fluorescence resonance energy transfer (FRET). We will carry this technology to the sensitivity required for the postulated quantal cAMP-signals and - develop new FRET-sensors for cAMP with much greater brightness, amplitude and sensitivity, - build a specially designed total internal reflection fluorescence (TIRF) microscope to image the sub-membrane region of intact cells, - apply the technology to systems of increasing biological complexity: (a) isolated thyroid cells, where cAMP-signals can be compartmentalized, (b) intact thyroid follicles, where cAMP-signals can be triggered from various cellular sites, and (c) individual neurons in Drosophila brain, which are involved in a defined learning process. We believe that the ability to analyze 2nd messenger responses from individual receptors will open the way to a molecular understanding of receptor function and cAMP-signalling and provide a widely applicable technology and a mechanistic basis for receptor-directed drug development.

Keywords: receptors,g-proteins,signal transduction,fluorescence,camp,single molecule detection
Towards two-person neuroscience (BRAIN2BRAIN)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: ERC Advanced Grant Interdisciplinary Panel
Countries involved: Finland
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-01-01
End date: 2014-12-31
Duration (months): 72.0
Total project cost (EUR): 2489643.0
EU funding (EUR): 2489643.0
Participants: 1
Project status: CLOSED

Humans interact with other people throughout their lives. This project aims to demonstrate that the complex social shaping of the human brain can be adequately tackled only by taking a leap from the conven-tional single-person neuroscience to two-person neuroscience. We will (1) develop a conceptual framework and experimental setups for two-person neuroscience, (2) apply time-sensitive methods for studies of two interacting persons, monitoring both brain and autonomic nervous activity to also cover the brain body connection, (3) use gaze as an index of subject s attention to simplify signal analysis in natural environments, and (4) apply insights from two-person neuroscience into disorders of social interaction. Brain activity will be recorded with millisecond-accurate whole-scalp (306-channel) magnetoencepha-lography (MEG), associated with EEG, and with the millimeter-accurate 3-tesla functional magnetic reso-nance imaging (fMRI). Heart rate, respiration, galvanic skin response, and pupil diameter inform about body function. A new psychophysiological interaction setting will be built, comprising a two-person eye-tracking system. Novel analysis methods will be developed to follow the interaction and possible synchronization of the two persons signals. This uncoventional approach crosses borders of neuroscience, social psychology, psychophysiology, psychiatry, medical imaging, and signal analysis, with intriguing connections to old philosophical questions, such as intersubjectivity and emphatic attunement. The results could open an unprecedented window into human human, instead of just brain brain, interactions, helping to understand also social disorders, such as autism and schizophrenia. Further applications include master apprentice and patient therapist relationships. Advancing from studies of single persons towards two-person neuroscience shows promise of a break-through in understanding the dynamic social shaping of human brain and mind.

Keywords: magnetoencephalography,functional magnetic resonance imaging,eye tracking,social interaction,autonomic nervous system
TRANSCRIPTOMICS IN CANCER EPIDEMIOLOGY (TICE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: Norway
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-01-01
End date: 2014-06-30
Duration (months): 66.0
Total project cost (EUR): 2428965.73
EU funding (EUR): 2300000.0
Participants: 1
Project status: CLOSED

NOWAC is the first prospective study with a globolomic design. This is an extension of the current cohort study with its questionnaire information and biological material for analysis of biomarkers, proteomics and single nucleotide polymorphisms (SNPs). The design of NOWAC adds biological material for analysis of the transcriptome in prospectively collected buffered peripheral blood samples, the postgenome biobank. Further, both peripheral blood and tumor tissue are collected from breast cancer patients diagnosed within the cohort together with matched controls. The latter biological material gives a new multidimensional design with a unique biological material at the end-point. The transcriptomic analysis will include both mRNA and miRNA as new technology (microarray and massive parallel sequencing) allows large scale studies. miRNAs could be promising markers for pathways analysis related to the carcinogenic process and for diagnosis and screening tests of breast cancer. These high-troughput technologies have analyses challenges both in bioinformatics and biostatistics therefore success depends on the development of new analytical strategies.This novel design is the observational counterpart to systems biology, or systems epidemiology. Systems epidemiology will seek to understand biological processes by integrating observational derived pathways information into the current prospective design. A true interdisciplinary approach has been implemented. The upside is the potential for an improved understanding of causality in epidemiology by opening up for quantification of traditional criteria of biological plausibility in a more complete biological model. The postgenome biobank with 50 000 participants out of the 172 000 participants in NOWAC and its unique national design and richness of biological material makes it a very strong case for interdisciplinary collaboration based on a population-based study representative of the real and complex lifestyle environment.

Keywords: epidemiology,cancer,transcriptomics