Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dynamic proteomic maps of stem cell-derived neurons as a mechanistic discovery pipeline for rare neurological disease (RARE MAPS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2023-01-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

Rare diseases are a major unmet medical need, as is the definition of the relevant disease mechanisms. Many rare diseases affect the nervous system. These are challenging to treat, and mechanistic studies are difficult due to the inaccessibility of patient tissue. Global proteomic studies have provided insight into whole tissue or cell changes in protein abundance but lose information on protein subcellular localisation, which is important because defects in protein trafficking are implicated in many neurological disorders. In ‘RARE MAPS’ I propose an unbiased mechanistic discovery pipeline combining human induced pluripotent stem cells (hiPSCs) with advanced spatial proteomics. I will use a method developed by Dr. Borner called ‘dynamic organellar maps’, which provides quantitative protein subcellular localisation information at the whole proteome level. Used comparatively, it can detect changes in protein localisation due to a perturbation, allowing unbiased screening for phenotypic changes. To develop this workflow, I will apply it to the rare neurodegenerative disorder AP-4 deficiency syndrome. AP-4 knockout hiPSCs will be differentiated into cortical neurons and maps will be made of intermediate cortical stem cells and mature cortical neurons. Comparison to control cells will enable the detection of changes to protein localisation and abundance. I will also apply the maps to brain tissue from an AP-4 deficient mouse model to detect protein mislocalisation in vivo. I will then use CRISPR/Cas9 technology to investigate the role of novel and known AP-4-associated proteins in neuronal autophagy and axonal health. This project will demonstrate the utility of dynamic organellar maps to reveal molecular mechanisms of rare neurological disorders as well as provide new insights into the pathogenesis of AP-4 deficiency and the role of protein trafficking and autophagy in the axon.

Keywords: mass spectrometry,induced pluripotent stem cell,neuron,axon,gene editing,crispr,adaptor protein complex,autophagy,neurodegeneration,hereditary spastic paraplegia,vesicles
Prosperity through innovation and promotion of Sustainable Urban Mobility Plans (Prosperity)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Italy,Austria,Cyprus,Lithuania,Bulgaria,Croatia,Croatia,Hungary,Poland,Romania,Slovenia,Bulgaria,Romania,Slovenia,Belgium,Hungary,Poland,Czechia,Czechia,United Kingdom,Portugal
Call: Strengthening the knowledge and capacities of local authorities (H2020-MG-2015_TwoStages, 2015)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 3188049.0
EU funding (EUR): 3188049.0
Participants: 27
Project status: CLOSED

PROSPERITY will: 1. Produce a culture shift in terms of environment for SUMPs in member states and in the organisational culture of transport planning in city authorities. 2. Get ministries and national agencies to play a national leading role on SUMPs, as in many member states these are the organisations from which cities take their main direction; where ministries are already playing this role, to support and strengthen their approach. 3. To provide mechanisms and tools for Ministries to take this lead role. 4. Analyse clearly the problems of (lack of) take-up of SUMPs – to understand from cities themselves why they are not taken up and then to help cities to address these barriers. 5. Extend the existing 25-county EU-SUMP-network with at least two more countries 6. Get more cities to take up effective high quality SUMPs – through cities’ involvement in the project and indirectly through more cities hearing about SUMPs in their country. 7. Ensure that these SUMPs contain and will lead to implementation of a broad range of innovative sustainable transport measures. 8. Build cities’ capacity to develop and implement SUMPs that genuinely reflect the spirit of the EU SUMP Guidelines, rather than being mandatory documents to fulfil a requirement linked to major transport infrastructure. 9. Deliver a measurable impact. The core concept of PROSPERITY is bringing ministries into the project, which will significantly enhance the visibility of the project at the national level and therefore increase numbers of cities active on SUMPs. Thus PROSPERITY will ensure that more cities commit to SUMPs that are in line with the EU SUMP Guidelines and that include a broad range of innovative measures. This will generate a high leverage factor, especially in regions and cities where take up is so far low and the impacts from transport are severe – therefore the majority of PROSPERITY activities is in such regions and cities - thus in southern, central-eastern and eastern Europe.

Keywords: national networks,tools,innovation
Unveiling the dark universe with gravitational waves: Black holes and compact stars as laboratories for fundamental physics (DarkGRA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Italy
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-10-01
End date: 2023-09-30
Duration (months): 72.0
Total project cost (EUR): 1337480.94
EU funding (EUR): 1337480.94
Participants: 1
Project status: SIGNED

In recent years, our theoretical understanding of the strong-field regime of gravity has grown in parallel with the observational confirmations that culminated in the landmark detection of gravitational waves (GWs). This synergy of breakthroughs at the observational, technical, and conceptual level offers the unprecedented opportunity to merge traditionally disjoint areas, and to make strong gravity a precision tool to probe fundamental physics. The aim of the DarkGRA project is to investigate novel effects related to strong gravitational sources -such as black holes (BHs) and compact stars- that can be used to turn these objects into cosmic labs, where matter in extreme conditions, particle physics, and the very foundations of Einstein's theory of gravity can be put to the test. In this context, we propose to explore some outstanding, cross-cutting problems in fundamental physics: the existence of extra light fields, the limits of classical gravity, the nature of BHs and of spacetime singularities, and the effects of dark matter near compact objects. Our ultimate goal is to probe fundamental physics in the most extreme gravitational settings and to devise new approaches for detection, complementary to laboratory searches. This groundbreaking research program -located at the interface between particle physics, astrophysics and gravitation- is now made possible by novel techniques to scrutinize astrophysical compact objects, by current and future GW and X-ray detectors, and by the astonishing precision of pulsar timing. If supported by a solid theoretical framework, these new observations can potentially lead to surprising discoveries and paradigm shifts in our understanding of the fundamental laws of nature at all scales.

Keywords: black holes,gravitational waves,event horizon,spacetime,singularity,superradiance,neutron stars,dark matter,pulsars
European Cloud In-Memory Database Appliance with Predictable Performance for Critical Applications (CloudDBAppliance)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Greece,Greece,France,Portugal,United Kingdom
Call: Cloud Computing (H2020-ICT-2016-1, 2016)
Start date: 2016-12-01
End date: 2019-11-30
Duration (months): 36.0
Total project cost (EUR): 4832132.5
EU funding (EUR): 4832132.0
Participants: 12
Project status: CLOSED

The project aims at producing a European Cloud Database Appliance for providing a Database as a Service able to match the predictable performance, robustness and trustworthiness of on premise architectures such as those based on mainframes. The project will evolve cloud architectures to enable the increase of the uptake of cloud technology by providing the robustness, trustworthiness, and performance required for applications currently considered too critical to be deployed on existing clouds. CloudDBAppliance will deliver a cloud database appliance featuring: 1. A scalable operational database able to process high update workloads such as the ones processed by banks or telcos, combined with a fast analytical engine able to answer analytical queries in an online manner. 2. A Hadoop data lake integrated with the operational database to cover the needs from companies on big data. 3. A cloud hardware appliance leveraging the next generation of hardware to be produced by Bull, the main European hardware provider. This hardware is a scale-up hardware similar to the one of mainframes but with a more modern architecture. Both the operational database and the in-memory analytics engine will be optimized to fully exploit this hardware and deliver predictable performance. Additionally, CloudDBAppliance will deal with the need to tolerate catastrophic cloud data centres failures (e.g. a fire or natural disaster) providing data redundancy across cloud data centres.

Keywords: appliance,data base,big data
IST-Africa (2016 - 2018) (IST-Africa 2016-2018)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Ethiopia,Uganda,South Africa,Egypt,Ireland,Namibia,Tunisia,Tanzania, United Republic of,Mauritius,Burundi,Botswana,Cameroon,Kenya,Lesotho,Mozambique,Malawi,Senegal,Eswatini
Call: International partnership building in low and middle income countries (H2020-ICT-2016-INT, 2016)
Start date: 2016-10-01
End date: 2018-12-31
Duration (months): 27.0
Total project cost (EUR): 800000.0
EU funding (EUR): 800000.0
Participants: 18
Project status: CLOSED

IST-Africa (2016 - 2018) has 4 complimentary objectives focused on strengthening ICT-related research and innovation cooperation between Europe and Africa: 1) Foster greater coordination of research and innovation activities; 2) Strengthen research and innovation linkages, increase awareness of research and innovation capacity and cooperation opportunities, and support mutually beneficial collaboration; 3) Monitor research and innovation activities in 17 IST-Africa Partner Countries to identify and provide input on common R&D priorities and future cooperation opportunities; and 4) Promote participation in ICT-39-2017 and other relevant Horizon 2020 calls, disseminate results from ICT-39-2015 and other relevant calls. IST-Africa (2016 - 2018) leverages results and achievements from previous phases of IST-Africa to realise its objectives. Coordination will be undertaken through national Horizon 2020 Train-the-Trainer Workshops and stakeholder meetings. Help Desk activities, international conferences and engagement with African and European stakeholders will assist in strengthening research and innovation linkages. Surveys will be undertaken across the 17 participating African Member States to monitor ICT-related research and innovation activities, map research and innovation capacity, priorities and bilateral cooperation initiatives to support future planning. Relevant calls will be promoted and results disseminated through national and international dissemination channels, physical meetings and conference presentations. All activities are well aligned with the work programme priorities through the organisation of research and innovation events and conferences with policy dimensions, monitoring of research and innovation activities, identification of common R&D priorities, strengthening linkages, raising awareness of collaboration opportunities, dissemination of results and building on the achievements of an ongoing Support Action for Africa.
Science for Life (SciFe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Slovenia,Slovenia,Slovenia,Slovenia,Slovenia
Call: European Researchers' Night (H2020-MSCA-NIGHT-2016, 2016)
Start date: 2016-04-01
End date: 2017-11-30
Duration (months): 20.0
Total project cost (EUR): 158994.5
EU funding (EUR): 158994.5
Participants: 5
Project status: CLOSED

Main objectives of the SciFe proposal is to bring researchers to the general public, to inspire youngster to embark on scientific careers, to increase awareness of importance of research and innovation activities, with a view to supporting the public recognition of researchers creating an understanding of the impact of researchers' work on citizen's daily life. For that purpose the awareness campaign (AC) to convey messages under the slogan “Science for Life” will be used in 2016 and 2017. On Fridays 30.9.’16 and 29.9.’17 SciFe events will be organized with renewed programs in festive and fun atmosphere in Ljutomer, Maribor, Brežice, Ljubljana, Koper, Izola and Nova Gorica. All SciFe events’ activities aim at offering the public at large an opportunity to cooperate in fascinating experiments, demonstrations, observations etc., to socialize and have fun with researchers in a relaxed atmosphere. The program is appropriate for public in general, regardless their scientific program and especially designed for youngest. SciFe programs’ red line is contribution of science to life in various aspects. The »European corner« will be prepared in the heart of every RN location: the visitors will be offered information on EC’s various actions and programs, EU material, “the Charter and the Code”, information how young people can become researchers and Framework Program witness’s experiences. Intensive awareness campaign is designed according to its main target. The rich communication mix includes active engagement of the young people through the public call targeting primary and secondary schools. Last but not least, the impact assessment will focus to measure the success and the impact of SciFe activities. All that will be achieved through consortium management of all WPs and harmonised communication mix with general public which takes into account existing recognition of the RN event in certain region and its number of inhabitants.

Keywords: profession,researcher,young,general public,awareness,stereotypes,eu funding,research,innovation,edutainment
Easy-to-use and highly accurate medical software for quantitative assessment of impairments in neurologically injured people. (ReHaptix)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-06-01
End date: 2019-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Neurological disorders, caused by either stroke, multiple sclerosis (MS) or Parkinson’s diseases affect more than 30M people worldwide. Currently, Europe has the greatest percentage of population aged 65 or over (25%) and these numbers are expected to drastically grow (3% per year) increasing the population affected by these chronic conditions. Neurological rehabilitation is an expensive doctor-supervised program designed for treating these diseases. However, there is currently no effective assessment to objectively measure and monitor the rehabilitation progress. Current solutions for performing assessments do not provide clinical evidences of their validity, show lack of accuracy and are limited to one disease type. ReHaptix has developed a medical software, designed for remote quantitative assessment of impairments in neurologically injured people. ReHaptix has developed 9 tests so far, of which 4 have been clinically validated (the gold standard), and 5 are currently under clinical validation. Healthcare Professionals (HCPs) can use the ReHaptix tests to evaluate their patients in the hospital, rehabilitation clinic or private practice, or patients can perform the tests autonomously at home on a touchscreen tablet, which empowers them about their recovery. Furthermore, patients can remotely share their results with their HCPs, who can adapt the treatment and medication, or schedule medical appointment and home-setting assessments as required. During the feasibility assessment, a go-to-market strategy and a supply chain will be established, as well as further development plan will be drafted. During the second phase of innovation project, ReHaptix will optimize the software increasing the number of tests and developing a functional mHealth app. Clinical trials will then be initiated to obtain the CE mark as a medical device.

Keywords: digital quantitative assessment,neurological diseases,rehabilitation remote monitoring,medical software
A commercial platform providing operational Air Quality services using EO data (AirQast)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Innovation actions
Countries involved: Spain,Spain,Belgium,Finland,Greece,Netherlands
Call: Downstream applications (H2020-EO-2017, 2017)
Start date: 2017-11-01
End date: 2020-02-29
Duration (months): 28.0
Total project cost (EUR): 2178737.5
EU funding (EUR): 1876956.25
Participants: 6
Project status: CLOSED

The ambition of AirQast (previously BlueSky) project is to build a self-sustainable service platform providing Air Quality services based on Earth Observation data. These services will provide updated emissions inventories, advanced forecasting systems and decision making tools to manage air quality events in order reduce their economic and societal impact. This platform will cover pollutants having a higher economic and social impact such as PM2.5, PM10, SO2, NO2 and CO. AirQast team wants to demonstrate the viability and sustainability of AirQast platform through developing business cases in new identified markets such as Mobile Apps, Smart Home Devices, Green Supply Chain Industries, Insurance Risk, Smart Cities and Real Estate as well as established markets such as Environmental Regulation and Planning. We want also to develop our platform services in markets where the impact will be higher and where the sustainability of the project will be easier. These markets will be Europe, China and India. We already engaged real key potential customers from these markets. AirQast project would also like to build a one-stop portal platform containing tools and functionalities that facilitate and simplify the access, visualization and management of the large volume data generated. We think that improving data handling combined with an innovative and attractive communication strategy is a must to bridge some existing gaps between existing potential customers and our team.

Keywords: air quality,emissions inventory,forecasting systems,decission making tools,green supply chain
Directly reprogrammed renal cells for targeted medicine (DiRECT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-03-01
End date: 2024-02-29
Duration (months): 60.0
Total project cost (EUR): 1499917.0
EU funding (EUR): 1499917.0
Participants: 1
Project status: SIGNED

The global incidence of kidney disease is on the rise, but little progress has been made to develop novel therapies or preventative measures. New methods to generated renal tissue in vitro hold great promise for regenerative medicine and the prospect of organ replacement. Most of the strategies employed differentiate induced pluripotent stem cells (iPSCs) into kidney organoids, which can be derived from patient tissue. Direct reprogramming is an alternative approach to convert one cell type into another using cell fate specifying transcription factors. We were the first to develop a method to directly reprogram mouse and human fibroblasts to kidney cells (induced renal tubular epithelial cells - iRECs) without the need for pluripotent cells. Morphological, transcriptomic and functional analyses found that directly reprogrammed iRECs are remarkably similar to native renal tubular cells. Direct reprogramming is fast, technically simple and scalable. This proposal aims to establish direct reprogramming in nephrology and develop novel in vitro models for kidney diseases that primarily affect the renal tubules. We will unravel the mechanics of how only four transcription factors can change the morphology and function of fibroblasts towards a renal tubule cell identity. These insights will be used to identify alternative routes to directly reprogram tubule cells with increased efficiency and accuracy. We will identify cell type specifying factors for reprogramming of tubular segment specific cell types. Finally, we will use of reprogrammed kidney cells to establish new in vitro models for autosomal dominant polycystic kidney disease and nephronophthisis. Direct reprogramming holds enormous potential to deliver patient specific disease models for diagnostic and therapeutic applications in the age of personalized and targeted medicine.

Keywords: direct reprogramming,renal tubule cells,kidney development