Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Novel computational avenues in protein-protein docking (NAUTIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Bringing a new drug to the European market takes at least 10 years and 2.5 BEUR of R&D effort. Computational methods significantly shorten this journey but they require knowledge of the structure and interactions of the involved biomolecules - most often proteins. In recent years, a tremendous progress has been made in the field of a single protein 3D structure prediction. However, predicting protein assemblies -the most crucial step - still remains very challenging. The aim of this IF project is to revolutionise protein complexes prediction methods. This will be achieved first by developing novel, effective and fast approaches for the calculation of the vibrational entropy, key to protein-protein docking mechanisms. Then, in an innovative and multi-disciplinary approach, the Experienced Researcher (ER) aims to combine advanced physics-based models with machine learning methods using data from structural and sequence databases. Finally, this project will link all the pieces together and release them in the form of a web-server in order to allow the community to benefit from the results of this research. The ER will carry out the fellowship in the Centre National de la Recherche Scientifique - CNRS in Grenoble, France. CNRS carries out research in all scientific fields of knowledge and the Supervisor is a renowned expert in data science, computing, and software engineering. Through a well-thought two-way knowledge transfer and training plan, this project will benefit both the host institution and the ER in terms of scientific knowledge, network and open the path for new applications to potentially exploit at the European or global level. The project will also place the ER as a highly visible researcher in the field and ideally set her as a valuable resource for European industrial actors.

Keywords: protein protein docking,vibrational entropy,normal mode analysis,geometric machine learning,structural bioinformatics,algorithm development
Decoding the Lateral Expansion of Plant Stems (PLANTSTEMS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-08-31
Duration (months): 72.0
Total project cost (EUR): 1999000.0
EU funding (EUR): 1999000.0
Participants: 1
Project status: CLOSED

In contrast to animals, in which tissue proliferation in adult individuals is often pathological and deleterious, plants have evolved an indefinite growth habit. A remarkable but under-investigated example is the thickening of plant stems and roots: It is a purely postembryonic growth process and the group of stem cells responsible – the cambium – is derived from and embedded in fully differentiated tissues. Consequently, lateral plant growth has to integrate and overcome developmental and physical constraints imposed by participating tissues. This is especially significant in the context of the extracellular matrix, which fixes the position of plant cells relative to each other and provides mechanical support for the plant body. However, how cells sense and modulate their environment during this process is completely unknown. Here, I will leverage the unique growth mode of plants and explore the process of lateral stem growth in the reference plant Arabidopsis thaliana as a paradigm for postembryonic growth and tissue remodelling. Thereby I will address the fundamental question of how cell identities are reprogrammed in vivo and how basic cellular functions like interaction between cells and their matrix contribute to this process. To achieve this I will i) decipher the influence of the extracellular matrix on stem cell activity by cell type-specific modulation of matrix integrity; ii) decode the complex role of brassinosteroid hormones by tuning their activities during stem cell initiation; iii) record cell fate signatures by high-resolution 4-D expression maps for cambium subdomains; and iv) Identify novel signalling cascades connecting the extracellular matrix with underlying cells by forward genetics. Together my results will provide unprecedented insight into lateral stem growth – a process responsible for the accumulation of wood and a large proportion of terrestrial biomass and will reveal fundamental concepts of growth processes in adult organisms.
European Standardised Process Approach to Cognitive Evaluation in older people (E-SPACE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-02-01
End date: 2018-01-31
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

During this fellowship at Dublin City University (Ireland), the researcher will enhance, significantly, the clinical utility of existing traditionally used cognitive tests, particularly as it relates to the early detection and accurate diagnosis of mild cognitive impairment (MCI) and dementia. Cognitive difficulties represent the hallmark of many neurodegenerative conditions and, in relation to dementia, cognitive evaluation represents one major pillar of current methods of detection and diagnosis. There are, however, many difficulties with existing cognitive tests and this project has been designed to address this issue. The need for and the potential benefits of early and accurate detection of MCI and dementia is well-recognised. Early and accurate detection is, however, complex and, at present, is subject to high diagnostic error rates. With the expected advent of new effective drug treatments for different neurodegenerative diseases (e.g. Alzheimer’s disease), early and accurate diagnosis will be even more vital into the future. Using the principles of what is known as the Qualitative Process Approach (QPA), the goal of this project is to identify and develop a battery of cognitive tests, both in traditional paper-and-pencil form and, when clinically appropriate, in a computerised version, with the aim of enabling a wide range of clinicians improve early and accurate diagnosis. This fellowship will play a crucial role in the career of Dr. Unai Diaz Orueta by providing him with international research experience and making him a reference expert in international neuropsychological research. Patients, families and society will benefit for earlier detection, earlier intervention, and reduced healthcare costs, as the improvement in the accuracy of the diagnosis of neurodegenerative conditions will subsequently impact in planning appropriate early interventions and saving millions of Euros associated to both formal and informal care of older people with dementia.

Keywords: early detection of dementia,process based approach,cognitive evaluation,qualitative information
Mise en oeuvre des activités Enterprise Europe Network H2020 (KAM/EIMC) en Ile-de-France, en région Centre-Val de Loire, en Nouvelle Calédonie et en Polynésie française (EEN TOPIC2INNO 2019)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: France,France,France,France,France,France
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 353178.75
EU funding (EUR): 353177.5
Participants: 9
Project status: CLOSED

Implementation of the H2020 EEN activities in the geographical area covered by the the EEN TOPIC Consortium.

Keywords: h2020 een innovation europe companies
A fully integrated, animal-free, end-to-end modelling approach to oral drug product development (InPharma)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Ireland,Switzerland,Greece,Switzerland,Belgium,Sweden,Czechia,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 3464964.0
EU funding (EUR): 3464964.0
Participants: 11
Project status: SIGNED

Oral drug products are preferred by hundreds of millions of patients in Europe. Yet, the challenges around formulating drugs for oral administration have increased tremendously over the last 30 years, mainly because most drugs coming through the Pharma pipeline are too poorly soluble to be efficiently absorbed from the GI tract. A quantum leap in identifying the optimal formulation for a new drug in the most efficient way possible is urgently needed to keep the Pharma industry in Europe competitive. Further, due to the enormous challenges in formulating poorly soluble drugs for oral administration, the numbers of animals used to screen formulation prototypes are increasing, despite EU commitment to reducing animals in research. The InPharma Consortium provides a unique solution to solving these important challenges. The InPharma EID will strengthen Europe’s innovation capacity and leadership in the Pharma sector, specifically in drug formulation. Exceptional intersectoral training will be provided to 13 ESRs through pioneering research focused on harnessing computational pharmaceutics, Biorelevant in vitro testing and PBPK modeling, generating an integrated, end-to-end, animal-free approach to formulating poorly soluble drugs for oral administration. ESRs will undergo specialized training program to build proficiency in essential research and industry disciplines, while training in professional skills and entrepreneurship will prepare them to become trailblazers in pharmaceutical formulation. A highlight of InPharma is the proven, successful collaboration among Consortium experts in the design, evaluation and implementation of enabling formulations for oral delivery. This EID will immerse ESRs in highly dynamic industrial environments under the supervision of leading academics, exposing them to all elements of pharmaceutical formulation, fostering collaboration, catalyzing synergies across the network and ultimately creating a truly unique training experience.

Keywords: 3rs in drug development,oral drug absorption,computational pharmaceutics,biorelevant in vitro testing,physiologically based pharmacokinetic pbpk modelling,drug formulation,machine learning
The role of protein degradation in FBXO11-related intellectual disability (Degradation_ID)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 174806.48
EU funding (EUR): 174806.4
Participants: 2
Project status: CLOSED

Neurodevelopmental disorders (NDDs) are genetically extremely heterogeneous with mutations in more than 1000 genes being causative. NDD-related genes and encoded proteins are involved in a wide range of various biological processes. Recently, several genes involved in protein degradation have been implicated in NDDs. This suggests that defects in protein homeostasis may be a recurring theme in neurodevelopment and cognition. We have recently identified de novo mutations in the nuclear E3-ubiquitin ligase complex component FBXO11 in 20 patients with a variable neurodevelopmental disorder. Loss-of function or haploinsufficiency of FBXO11 is the most likely mechanism for FBXO11-related NDDs. The pathomechanism of how FBXO11deficiency may lead to (neuro)-developmental defects has yet to be established. The objective of this project is to understand the role FBXO11 defects may play in the development of NDDs. In aim 1 I will focus on deciphering the molecular function of FBXO11 using two complementary approaches: identifying FBXO11 substrates using affinity-purification mass-spectrometry approaches and identifying pathways affected by FBXO11 dosage alterations using transcriptomic approaches. The identification of FBXO11 substrates and downstream pathways will lead to a better understanding of its role in neurodevelopment and in NDDs. In aim 2 I will characterize the role of Fbxo11 in neurodevelopment by modeling Fbxo11 deficiency in Drosophila melanogaster and investigate the potential to manipulate phenotypes by supplementation of fly food with proteasome activators. Collectively, this project will furthermore open a window to better understand the role alterations of protein degradation may play for NDDs in general.
Isotope CYcling in the LABrador Sea (ICY-LAB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-07-01
End date: 2021-12-31
Duration (months): 66.0
Total project cost (EUR): 1999885.0
EU funding (EUR): 1999885.0
Participants: 1
Project status: CLOSED

The high-latitude regions are experiencing some of the most rapid changes observed in recent decades: polar temperatures are rising twice as fast as the global mean and there are concerns about the impact of sea-ice and glacier retreat on global oceans and climate. The high-latitude North Atlantic is also a key region for ecologically and economically important natural resources such as fisheries. How these resources will change in the future depends strongly on the response of marine biogeochemical cycling of essential nutrients to increasing anthropogenic stress. Diatoms are photosynthetic algae that are responsible for nearly half of the export of carbon from the sea surface to the seafloor, and they are a sensitive indication of the state of nutrient cycling. Diatoms are one of many organisms that precipitate biogenic opal, an amorphous glass made of silica (hydrated SiO2), to form protective skeletons, and one of the essential nutrients is therefore dissolved silicon (Si) in the form of silicic acid. The response of the silicon cycle to changing environmental conditions is critical for both carbon and nutrient cycling and it can now be addressed through high precision silicon isotopes, which is the focus of ICY-LAB. The approach will be to capture the whole silicon cycle system in areas of marked environmental change using careful field sampling strategies - with research expeditions to coastal Greenland and the open ocean Labrador Sea - coupled with cutting-edge analytical methods. The results will lead to an unprecedented and cross-disciplinary view of nutrient cycling, biomineralisation, and the taxonomy and biogeography of siliceous organisms in an ecologically important region of the North Atlantic. ICY-LAB is an exciting and novel project for which I am ideally placed to carry out, allowing me to develop a new method for looking at modern biogeochemical processes, adding to my existing palaeoclimate and biochemical expertise.
Advanced Contactless Multifunction Control unit with gesture detection (ACMC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Slovenia
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The Advanced CMC project will deliver breakthrough innovation - new type of human/computer interface, based on contactless multifunction control unit with gesture detection. The interface uses a type of sensor, that can penetrate (works through) wide range of non-conducting materials, including natural wood, stone, glass, artificial materials, ceramics etc. It can be covered or even hidden behind any surface, while recognizing hand gestures through the cover plate and translating them to digital outputs, offering unlimited looks, including invisibility (mounted behind drywall or paneling). We envision multiple benefits of this technology, from intuitive, organic and user friendly input interface to groundbreaking design options, that this technology offers for an input devices. Touchless gesture input unit has countless applications, but focus of the project is the application of the Anigmo CMC gesture interface technology in the lighting and smart home markets. Our initial use of Anigmo CMC technology is to provide aesthetic and functionally elegant contactless gesture controls, that allow unprecedented visual customization and ease of use. ACMC project brings new concept into the ICT technology, specifically into the human/computer interfaces area. ACMC concept is pushing the technology’s boundaries. It creates new opportunities and challenges for the entire global market. We will add an entirely new dimension to the global ICT market, which is one of the fastest growing markets. This proves a novelty in the European and global market, which will benefit from the innovative technology and applications that are not yet available on the market. Our innovation will solve all problems competition is dealing with, but on the other hand customers demand it: adaptable appearance, unlimited design possibilities, ease of use, no need for buttons, control unit operated with gestures, wide range of use, lower price

Keywords: contactless control unit,intelligent houses,input device,hand gesture detection
Regional Religious Networks in the Roman Empire (RENE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-08-15
End date: 2022-10-28
Duration (months): 24.0
Total project cost (EUR): 202158.72
EU funding (EUR): 202158.72
Participants: 1
Project status: CLOSED

RENE is a first interdisciplinary study to investigate interactions between rural and urban cult sites, their communities, the diffusion of religious traditions and architectural style, the regional mobility of elite (temple benefactors and dedicators), and how the latter affected religious traits. It is based on published archaeological, epigraphic and sculptural materials in two extreme parts of the Roman Empire. They are: the Hauran (Southern Syria), and Lusitania (roughly Portugal and the western part of Spain) from the pre-Roman to the Roman period periods (the second century BC to the third century AD). It will examine their variation and reasoning by contextualising the study areas within their geography and their socio-political background, which will contribute to scholarly debates on the Roman world from the West to the East. It will reevaluate rural and urban cult sites as multifaceted indicators of continuous evolving religious processes and of fluctuating contexts shaped by interactions of different social and political actors through the emergent computer-based method of social network analysis (SNA) that I will learn thanks to the training programme offered by Marie Skłodowska-Curie fellowship. The database of cult sites, their SNA models and results of RENE will be freely available on the project’s website which I will create thanks to the training programme of the fellowship.

Keywords: gods,rural,urban,architecture,epigraphy,cultures,religious identities,near east,western roman empire
Tension of ENDOmembranes maintained by TORC1 (TENDO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-05-01
End date: 2024-10-31
Duration (months): 66.0
Total project cost (EUR): 2257546.0
EU funding (EUR): 2257546.0
Participants: 1
Project status: SIGNED

The target of the bacterial macrolide rapamycin, TOR, is a ser/thr protein kinase that assembles into two distinct protein complexes, conserved from yeast to human, we named TORC1 and TORC2. TORC1 is directly bound and inhibited by rapamycin and studies with rapamycin have revealed that TORC1 plays a central role in coupling nutrient cues to biomass synthesis and turnover. The lack of a specific inhibitor for TORC2 has made the study of this complex much more challenging. We overcame this challenge by solving the structure of yeast TORC2 which revealed why it is insensitive to rapamycin and enabled us to create a rapamycin-sensitive TORC2 variant. We also developed two small molecules, one that dissipates plasma membrane (PM) tension and the other that serves as a biosensor of PM tension. With this suite of chemical-biology tools we confirmed that TORC2 functions in a mechanotransduction pathway to maintain tension homeostasis of the PM. Concurrently, solving the structure of TORC1 revealed that its activity is regulated via assembly into a huge, inactive helix which we named a TOROID – TORC1 Organized in an Inactive Domain. In this grant, was ask if these major advances are transferable; i.e. can lessons learned regarding TORC2 be applied to TORC1, and vice versa? Our major aim is to determine if and how TORC1 regulates vacuolar membrane (VM) tension. To this end, we will develop novel chemical probes to monitor VM tension and we will use genetic screens, quantitative phosphoproteomics, in vitro assays, high-throughput compound screens, STORM and FRAP imaging, and state-of-the-art cryo-EM to learn how TORC1 senses and regulates VM tension. Our other aim, prompted by our TOROID discovery, is to solve the TOROID-like structure that TORC2 forms upon glucose depletion. This work will reveal new mechanisms in growth control, and details in TORC1 and TORC2 regulation that may inform future therapeutic interventions for these medically relevant signalling complexes.

Keywords: target of rapamycin tor signaling