Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Energy Consumption Gamified - Greenely Feasibility Study (ECGGFS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Sweden
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2017-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Greenely is a mobile application that provides a visual representation of energy usage, translating raw energy data from smart meters into algorithmic visuals of consumption patterns by hour, day or month; promoting sustainable energy consumption through behavioural data analysis and gamification. Energy Behaviour Gamified: In the last few years, more than 100 million smart meters have been installed in the EU, enabling energy data analysis for energy efficiency, allowing households to access new information to understand their consumption. Greenely is an IT SME disrupting energy efficiency by innovating sustainable energy practices by consumers in the retail market, bringing long-overdue technological advances to the power sector, and valuable data on energy behaviour to researchers. Without Greenely, households are often requested to pay electricity companies to access analysis of their energy consumption data by buying and installing a specific type of hardware to monitor consumption. Greenely is free for consumers and has developed algorithms that can translate the raw energy data and present it in a modern way that is available at any time. This feasibility study will address the users, technology, market, IPR, commercialisation strategy, and partners/stakeholders.

Keywords: startup,energy,energy consumption,household energy,gamification
Targeting SYNthetic lethal interactions for new cancer treatments TRAINing network (SYNTRAIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Italy,Switzerland,Greece,Greece,Sweden,Finland,Netherlands,Netherlands,United Kingdom,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2016-09-01
End date: 2020-11-30
Duration (months): 51.0
Total project cost (EUR): 3990269.16
EU funding (EUR): 3990269.16
Participants: 13
Project status: CLOSED

Breast and ovarian cancer constitute serious health challenges in the EU. To identify new improved cancer therapeutic approaches, we will pursue a multi-facetted synthetic lethal approach, which takes advantage of the inherent genetic instability of cancer cells. Most mutations acquired by cancer cells do not cause lethality, but the very same mutations may cause cell death when a second gene in a redundant pathway is inactivated. Thus, targeting a gene that is synthetic lethal together with a cancer-specific mutation will kill only cancer cells while sparing normal cells. Synthetic lethal approaches have been clinically pioneered by members of our consortium, by combining cancer-promoting mutations (e.g. in BRCA2) with inactivating combinations of DNA repair genes. We will use this approach as the scientific frame for our ETN (SYNTRAIN) consisting of 9 academic and 1 SME beneficiary as well as 3 partners. We aim to identify synthetic lethal interactions and exploit them to innovate future breast and ovarian cancer treatments through compound screening and development. SYNTRAIN consists of World leading researchers with complementary knowledge in genome maintenance and stress response pathways, and a critical mass of expertise for providing an excellent training in screening methodologies, mechanistic investigations, and drug discovery. We will offer a structured training program that exceeds the capacities of each individual member. We will educate a future generation of cancer researchers with a high innovative capacity and skills that enhances their career prospects in both academia and industry. Our aims are to train young researchers: i) in techniques preparing for a career in cancer research, ii) in complementary skills relevant for work in academia and the pharma industry and iii) to become creative and entrepreneurial, capable of bridging the gap between basic and applied research.

Keywords: synthetic lethal genetic interactions,targeting cancer cell vulnerabilities,dna replication stress,and genome maintenance,breast and ovarian cancer
The dark side of the genome: systematically studying the biology of repressive elements—silencers—in the human genome (Silencer)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1750000.0
EU funding (EUR): 1750000.0
Participants: 1
Project status: SIGNED

Less than 1.5% of the human genome contains protein coding information of the estimated 25,000 genes. The rest of the non-coding genome includes many regulatory elements that control the spatial and temporal transcription of genes. With the help of the non-coding regulatory elements, the diverse cell types and tissues of a complex human body could be derived from the combinational expression of a limited number of genes from the same copy of the genome. Most regulatory elements (REs) have been characterized extensively, e.g. promoters, enhancers and insulators. These REs have been implicated to play very important roles in cell physiology, tissue development and disease onsets. Surprisingly, one class of REs—silencers—which repress the transcription of genes, have not been systematically characterized and studied. I have developed a lentiviral system to systematically identify functional silencer elements. In the small-scale proof-of-principle experiments, by focusing on the transcriptional factor (TF) accessible DNA sequences, I showed that this system is robust to identify novel and bona fide silencers, which could be validated using complementary functional assays such as luciferase and CRISPR knockout assays. In this proposed research plan, I aim to identify silencers in an unbiased way, rather than focusing on TF accessible regions, to have a more general understanding of the biology of silencers. Based on the unbiased identification of silencers, I aim to identify a general pattern of epigenetic modifications of silencers, unique combination of sequence motifs, responsible regulatory TFs, biological pathways that are regulated by silencers, diseases that might be related to mutations in silencers, and finally better manipulation strategies of silencers.

Keywords: non coding genome,silencer,promoter,enhancer,screen,massively parallel reporter assays,dcas9 mediated proximal labeling,epigenetic
Mesoscopic models for propagation in biology (MESOPROBIO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 1091688.0
EU funding (EUR): 1091688.0
Participants: 1
Project status: CLOSED

According to biologists, there is a need for quantitative models that are able to cope with the complexity of problems arising in the field of life sciences. Here, complexity refers to the interplay between various scales that are not clearly separate. The great challenge of the MESOPROBIO project is to analyse complex PDE models for biological propagation phenomena at the mesoscale. By analogy with the kinetic theory of gases, this is an intermediate level of description between the microscale (individual-based models) and the macroscale (parabolic reaction-transport-diffusion equations). The specific feature common to all the models involved in the project is the local heterogeneity with respect to a structure variable (velocity, phenotypical trait, age) which requires new mathematical methods. I propose to push analysis beyond classical upscaling arguments and to track the local heterogeneity all along the analysis. The biological applications are: concentration waves of bacteria, evolutionary aspects of structured populations (with respect to dispersal ability or life-history traits), and anomalous diffusion. The mathematical challenges are: multiscale analysis of PDE having different properties in different directions of the phase space, including nonlocal terms (scattering, competition), and possibly lacking basic features of reaction-diffusion equations such as the maximum principle. The outcomes are: travelling waves, accelerating fronts, approximation of geometric optics, nonlocal Hamilton-Jacobi equations, optimal foraging strategies and evolutionary dynamics of phenotypical traits. Emphasis will be placed on quantitative results with strong feedback towards biology. The project will be conducted in Lyon, a French hub for mathematical biology and hyperbolic equations. There will be close interaction with biologists in order to establish the most appropriate questions to answer. Several collaborations in Europe (UK, Austria) will be developed.

Keywords: mathematical biology,collective motion,evolutionary dynamics,anomalous diffusion,travelling waves,accelerating fronts,kinetic equations,hamilton jacobi equations
Novel business based on high efficiency composting technology (HiCompost)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2014-11-01
End date: 2015-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

There is a trend towards encouraging biowaste management companies (solid waste and waste water treatment plants) and biowaste producers (shopping centres, food manufacturers, agricultural cooperatives and farms) to invest in composting plants in order to improve the treatment of organic waste. Additionally, laboratories are also installing composting facilities focussed on biomaterials testing taking into account that these materials, whose production is increasing year by year, need to be validated with regards to compostability requirements. Nevertheless, the composting technologies currently used by each of the three sectors present some drawbacks. Biowaste producers and managers use composting systems which needs large treatment areas and long times, produces compost not always compliant with quality standards and generates several problems such as low lixiviate control, fire risks and bad odours. Regarding labs, they need to adapt their facilities to the technical requirements of the compostability tests carried out, which generates high costs related to the time invested by technicians in making facilities compliant. BASTAN has been working on the design of composting technology to solve these limitations. These composters permit to reduce composting times, minimize investment and production costs, control process parameters and lixiviate generation, reduce bad odours and fire risks, as well as guarantee the required quality in the final compost. Therefore, the objective of the HiCompost project is to design and implement a business plan focussed on the broad penetration of BASTAN composters in these three market segments. This business plan will be based on three pillars: (1) technological improvement in comparison with traditional composting systems; (2) innovative service based on composting know-how adapted to each client; and (3) technology validation based on the technology alignment with the requirements on compost quality and testing.

Keywords: reduction of greenhouse gas emissions,resource efficiency,landfilling reduction,biowaste management companies,biowaste producers,biomaterial testing laboratories,composting technolog
Immune activity Mapping of Carbon Nanomaterials (CARBO-IMmap)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Italy,Spain,Italy,China,France,United States,Qatar
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-03-01
End date: 2022-02-28
Duration (months): 60.0
Total project cost (EUR): 967500.0
EU funding (EUR): 796500.0
Participants: 8
Project status: CLOSED

The CARBO-IMmap project involves key players in Europe, US, Qatar and China with the aim to advance the field of carbon nanomaterial development and their exploitation biomedical applications. The long-range goal of Carbo-IMmap is to develop a functional pipeline for the immune-characterization of carbon nanomaterials, for the qualitative and quantitative assessment in vitro and ex vivo of the human immune compatibility and immune activity of newly developed carbon materials. The project aims to: 1) design and synthetize a panel of 5 types of highly stable and water-soluble nanomaterials, characterized by finely tuned properties by controlling their size and composition, and to obtain these nanomaterials in large amounts with nearly identical size and shape and degree of functionalization; 2) achieve a quantitative understanding of the immune activity (stimulation/ anergy/ suppression) of the selected materials upon the 5 subpopulations of the immune blood cells; 3) correlate the physicochemical properties (size and chemical functionalization) of the nanomaterials with their immune properties; 4) establish a consolidated network between leading EU and extra-EU institutes to provide a stimulating international environment for talented young researchers; 5) advance the level of R&D in participant countries and foster technology transfer and dissemination; 6) raise the awareness of the general public on the prospects of carbon nanomaterials in future biomedical applications. Scientists will be formed by "training by research" stays at host labs, leading to an interdisciplinary and international formation. Funding of this program will enable long-term, transformative research collaborations that will contribute to the integration and collaboration of research groups of 4 European Countries (Germany, Italy, France and Spain) and 3 key non-EU Countries: USA, China and Qatar.

Keywords: graphene,carbon nanotube,carbon based nanomaterials,immunomics,nanotoxicology
Multifunctional Satellite Radiator (MSR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Hungary
Call: SME Instrument (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Multifunctional Satellite Radiator Securing space assets against man-made space debris present at frequently used orbits became integral part of space mission definition and overall spacecraft design. Radiator panels as part of the outer shell of spacecraft already provide some degree of protection to the instruments behind them. Overall project objective is to develop a new class of multifunctional structural radiators for small and medium satellite missions where high mechanical and thermal performance shall be combined with improved space debris and cosmic radiation protection characteristics. Radiator panels manufactured from aluminum foam sandwich (AFS) are able to fill the gap between conventional honeycomb and integrally milled structural radiators. Due to the lightweight core they offer high stiffness-to-weight ratio like honeycombs while the metallic bond between facesheet and core ensures superior load bearing capability and thermal conductance provided by integrally milled radiators. AFS radiators are capable to provide mechanical support for heavy electronic boxes, offer good thermal performance combined with enhanced radiation and debris protection for the hardware located behind the radiator panel. Main advantages of AFS radiators compared to existing honeycomb based radiators are: • high in plane thermal conductance without heat pipes due to isotropic core structure, • higher insert strength, • better debris protection, • better radiation protection, • originally thick face sheets can be manufactured according to mechanical and thermal needs, • improved outgassing parameters due to lack of adhesives, • easier grounding implementation due to metallic contact between core and face sheet. As the result of this development Europe will be the leader provider of satellite radiators meaning significant market share. It is also a promising business opportunity for a Hungarian SME whose country is being a full member of ESA.

Keywords: satellite,radiator,thermal,lightweight,debris protection,radiation protection
Exploring pathways for transformation to sustainability using the safe and just operating space concept at the regional level (SUccESS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-01
End date: 2021-01-31
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

SUccESS aims at identifying transformation pathways towards sustainability that are both safe, in terms of being within the ecological boundaries of a place, and just, in terms of being socially just. To achieve this at regional level, ecological boundaries and social foundations will be assessed, and these variables will be related to: 1) social foundations that need to be secured to avoid human deprivation; and 2) stakeholder's mental models of change, for chosen cases from Kenya. Based on these relationships, the initiative will explore pathways using a systems dynamic approach to ensure a safe and just operating space (SJOS) for transformation to sustainability. This integrative approach provides an innovative way to address the sustainability of social-ecological systems (SES) and their transformation options in a globalized context. This will also help to develop methodology aimed at defining boundaries for sustainable development that can be applied to identify tipping points, limits to growth and limits to adaptation across the world.

Keywords: sustainable development,safe and just operating space,social ecological system,system dynamic modelling
Development of an Intelligent Controller for Electro-motors (CoMoCo)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Netherlands
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Electric motors (EMs) and the systems they drive such as fans, pumps, and circulators are the single largest electrical end‐use. EM are found in industrial and commercial applications such as, pumps, fans, conveyors, lifts, ventilation, compressors, etc. EM’s are designed for a maximum usage and most efficient only during maximum usage. If lower than maximum, the EMs becomes inefficient. Most of the EMs (e.g. for elevator) are not used constantly with maximum load but with a partial load only. The here presented CoMoCo is an intelligent controller for EMs developed by CONTRONICS. Depending on the type of electro-motor and the required capacity, by regulating and controlling the consumption in real-time between 45 to 90 % electric energy can be saved. Our controller measures the electromagnetic field in the EM without using mechanical sensors. The built-in software accurately estimates where the magnetic field will be in the next microsecond. It calculates the minimum and the type of energy required to realize this field and then precisely supplies it, using the data obtained. Switching to energy efficient electro-motors can save Europe up to 202 billion kWh in electricity consumption, equivalent to a reduction of €10 billion per year in operating costs for industry, as well as a reduction of 79 million tonnes of CO2 emissions. CoMoCo was already tested and it demonstrated to be a cutting-edge, energy-efficient, economically accessible and profitable EM controller to reduce the energy consumption by 80% in ventilation systems operated in pig farms. In this proposal, the SME CONTRONICS is applying for funding of a feasibility study for verifying the further technological development as well as economic viability of the CoMoCo intelligent EM control, in diverse industrial applications.

Keywords: electric motors,energy optimization,intelligent controller,co2 emissions