Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High-Throughput Mapping of Antibody Sequences to Antigen Specificity in Placental Malaria (PAMSEQ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United States,Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2024-06-30
Duration (months): 30.0
Total project cost (EUR): 242605.44
EU funding (EUR): 242605.44
Participants: 2
Project status: SIGNED

Placental malaria (PM) is a severe malaria complication in pregnancy, in areas with stable parasite transmission. It is a major cause of disease and death among pregnant women and their offspring. PM mainly affects primigravidae, as immunity is developed over successive pregnancies. This naturally acquired protection to PM is mediated by antibodies targeting a parasite antigen called VAR2CSA. Although VAR2CSA is a variable antigen, it has been previously demonstrated that the naturally acquired antibody response is generally broadly cross-reactive (meaning that serum from a multigravidae woman can recognize multiple VAR2CSA variants). However, the results of recently conducted trials of a VAR2CSA-based vaccine to prevent PM showed almost complete variant-specificity of the induced antibodies (only the particular VAR2CSA variant used for immunization was recognized), failing at mimicking what occurs during natural infection. This research project aims to resolve that conundrum by studying in detail the specificity and sequence characteristics of VAR2CSA-specific antibodies generated during natural infection. Specifically, I will collect B cells from Ghanaian women with naturally acquired PM immunity. I will then identify B cells producing antibodies that can react with a panel of recombinant protein variants selected to represent the global variation in VAR2CSA. I will then use an innovative technology (LIBRA-seq) to simultaneously identify the exact antigen specificity of each single VAR2CSA-reactive B-cell and importantly the exact sequence of the antibody encoded by the cell. The latter information will allow me to produce recombinant antibodies to be tested for cross-reactivity towards recombinant and native VAR2CSA variants, and for their ability to neutralize the function of VAR2CSA. The project has major potential to accelerate development of VAR2CSA-specific vaccines against PM.

Keywords: placental malaria,var2csa,10x genomics,naturally acquired immunity
Mechanisms of kinesin-dependent RNA transport and translational regulation (RNA Transport and Control)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Active mRNA transport and localisation are crucial for spatiotemporal control of gene expression. In neurons, dendritic mRNA transport and local translational control are required for synaptic plasticity and memory formation. Misregulation has been linked to severe diseases. RNA-binding proteins (RBPs), kinesin motor proteins, mRNAs and noncoding RNAs (ncRNAs) are involved in dendritic mRNA transport and translational regulation. Still it is not known which essential set of factors is required to enable kinesin-dependent mRNA transport. Further, many RBPs required for mRNA transport simultaneously act as regulators of translation. How these crucial activities are mechanistically linked is unsolved. To anwswer these questions, this project aims to reveal essential mechanisms by two independent biochemical in vitro reconstitution approaches: (1) I will reconstitute kinesin-dependent transport of a dendritically localised mRNA and noncoding RNA using candidate proteins and RNAs from literature and an unpublished result of the host laboratory. (2) I will analyse the dual function of RBPs in mRNA transport and translational regulation. To this end, a microfluidics-coupled in vitro translation imaging assay (TIA) will be developed to study the effect of RBPs and ncRNAs on translation in real-time. Finally, the in vitro motility assay will be combined with the TIA to investigate the impact of translational regulation on mRNA transport. Using these techniques I will address key questions: (i) Which are the essential components required for kinesin-dependent mRNA transport? (ii) How are mRNA transport and translational regulation mechanistically connected? This project aims to unravel fundamental principles, improving our knowledge of neuronal mRNA transport and gene expression on a mechanistic level. Additionally, the experimental framework developed herein will enable the field to answer further important questions relating to the growing field of localised translation.

Keywords: kinesin,rna transport,in vitro reconstitution
Advance Nacelle Aerodynamic Optimisation (ANACO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: United Kingdom,United Kingdom
Call: Advance Nacelle Aerodynamic Optimisation (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-11-01
End date: 2022-11-30
Duration (months): 49.0
Total project cost (EUR): 2257998.75
EU funding (EUR): 2257998.75
Participants: 2
Project status: SIGNED

ANACO will facilitate the multi-objective optimisation of short and slim nacelle design for the next generation of ultra-high bypass ratio (UHBPR) aero engines. UHBPR engine architectures offer increased propulsive efficiency through operation at reduced specific thrust, enabled by increased engine diameter. This poses special challenges, both in terms of the aerodynamic drag of the isolated nacelle and the potential for interference effects which may be imposed by a close-coupled installation on the aircraft wing. ANACO will initially generate a population of short and slim nacelle designs which seek to minimise overall mission, rather than single design point, drag. These designs will be optimised using the latest numerical methods prior to down-select for isolated, high speed wind tunnel test enabling validation of the design tools applied. As part of this testing, experimental data quality will be improved by the enhancement of existing, and the development and application of novel, measurement techniques. The feasibility of simulating the installed wing pressure field during wind tunnel test will be assessed. The success of the optimised, down-selected geometries will also be investigated by simulation in an installed situation enabling both the overall performance improvements of the integrated wing and nacelle and the individual contributions to be understood. Finally, ANACO will deliver design rules and guidelines for future application in the design of novel, short and slim nacelles.

Keywords: nacelle aerodynamic optimisation cfd wind tunnel test validation
the Center for Genomics, Evolution and Medicine (cGEM)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Estonia
Call: ERA Chairs (H2020-WIDESPREAD-03-2017-ERAChairs, 2017)
Start date: 2018-09-01
End date: 2023-12-31
Duration (months): 64.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The proposed ERA Chair – the Center for Genomics, Evolution and Medicine (cGEM) aims to apply advancements in genomic medicine in an evolutionarily-aware framework to account for different evolutionary pathways of populations which have led to differences in susceptibility to common diseases. This requires the knowledge about the genetic risk factors for diverse ethnic groups and the tools to highlight the underlying genetic predisposition to diseases in complex human populations. For this reason, we will bring together the scientific expertise in three institutions: the Estonian Biocentre (EBC) and the Estonian Genome Center (EGC) which will be consolidated to form the Institute of Genomics at University of Tartu (IGUT) in January 2018, and the Institute of Clinical Medicine (ICM). The synergy between the three scientific hubs will create the research capacity for tackling the abovementioned aim. This capacity will be built to apply a holistic approach to understand the evolutionary driving forces that have led to common diseases; develop disease risk prediction models applicable in different populations, and explore the means for translating these findings into suitable input for everyday clinical practice. For these purposes we shall estimate the mutation rate across molecular pathways during the evolution, migration and mixing of the human populations, and study the roles of demographic history and local adaptation in the global patterns of mutation processes in humans exploring regional differences in the accumulation of mutations predisposing individuals to common complex diseases. the cGEM will utilize its international collaborations and in-house biobanks to advance the personalized medicine solutions for admixed populations for predicting risk of certain complex diseases, including metabolic and cardiovascular diseases, and cancers.

Keywords: genomics,evolution,personalized medicine,biobanks,non invasive diagnostics
SLADCORE as the new generation table sugar (SLADCORE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Slovenia
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

TOSLA's project SLADCORE aims to further develop a new generation of table sugar with 40 percent greater sweetness than table sugar. The corresponding technology development will be based on the natural modification of sucrose structure. According to WHO table sugar is public health enemy number 1. It is considered the main culprit for rising obesity throughout the world, including Europe. The food industry's main response to date has been focused on reduction of their product calory content by relying on alternative sweeteners. Most of these sweeteners failed to comply with industry standards regarding colour, aroma, texture, fermentation or shelf-life. More importantly, some of these sweeteners have been found to be greater health hazard than table sugar. TOSLA's innovative approach is based on the principle »fixing sugar is better than replacing it«. By using SLADCORE, which performs exactly like table sugar, food industry, especially its confectionery sector, would be able to reduce their product calory content without resorting to hazardous sweeteners. TOSLA has successfully established itself in the natural sweetener market with its flagship product, a unique, premium natural liquid sweetener InvertoseTM. SLADCORE represents a next step in an effort to expand the market of naturally modified sugar to confectionery producers and other sectors of the food industry. Many European confectionery SMEs already showed interest in SLADCORE by endorsing its feasibility and marketabilty. Furthermore, the proposed innovation grabbed the attention of other relevant stakeholders and a global industrial key player. The purpose of the SME 1 proposal is to outline the full scope of future development of TOSLA's latest innovative product: the analysis of technical and business feasibility issues, the associated risks, and the project`s commercial potential.

Keywords: sugar industry,confectionery,natural modification of sucrose structure,greater sugar sweetness,novel food,calorie reduction,spray drying technique
From heat to cold with THEAC-25®, the Thermo Acoustic Energy Converter. (THEAC 25)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-01-01
End date: 2019-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Due to climate change, space and process cooling is becoming the worldwide problem of the near future. With the raising of the average temperature, active air-conditioned cooling is needed throughout the year leading to high costs on electric power consumption (over 30% of the global electric power consumption in Europe, which means €27 billions), on maintenance for compressors as well as on the use of polluting refrigerants and its registration expenses. SOUNDENERGY BV introduces a breakthrough technology that brings a fundamental change in cooling buildings without using electricity or gas. Our company, based in The Netherlands, have a multidisciplinary team, with a well-known world leader researcher of Thermal Acoustics. Currently, we are developing the second generation of THEAC-25®converting heat into cold by using thermo acoustic technology. Our focus is to be able to provide climate control of buildings and industrial processes with zero CO2 emissions, saving 50% in energy consumption, which means between 5,000 - 20,000 kg of CO2 emissions/yearly reductions. The first version of THEAC-25® has been tested with some launching customers such as SENZORA BV. Pilot testing of the second generation of THEAC-25® with potential customers, will be contemplated as part of our commercialisation strategy. CE marking and FDA approval is sought to be able to commercialise on a global scale. SOUNDENERGY will follow a B2B approach to efficiently deliver climate cooling for industrial waste recovery as first target market (€600-700 M). Once we gain traction and market position we will focus on the space cooling for residential and non-residential buildings (€1.27B). We will be able to reach an addressable market size for waste heat recovery only in Europe of over €10M in 2021. Over 2,000 units of THEAC-25® and €40M sales projection has been estimated for the fourth year of commercialization (price €20k/per unit in Y4), with a ROI of 11.16

Keywords: sound energy,electric comsumption,thermal acoustics,thermo acoustic thechnology,cooling
Holistic management practices, modelling and monitoring for European forest soils (HoliSoils)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Uruguay,Germany,Spain,Spain,Lithuania,Romania,Slovakia,Sweden,Finland,Finland,France,France,Czechia,Netherlands,Netherlands,United Kingdom,Japan
Call: Forest soils Research and Innovation Action (H2020-SFS-2020-2, 2020)
Start date: 2021-05-01
End date: 2025-10-31
Duration (months): 54.0
Total project cost (EUR): 10035592.5
EU funding (EUR): 9999920.0
Participants: 21
Project status: SIGNED

Knowledge gaps on forest soil processes and lack of a harmonised soil monitoring limit the EU’s ability to maintain soil related ecosystem services and to reach climate policy targets. A better understanding of the soil processes and a harmonised approach to manage and integrate data to computational models that are used for decision making is urgently required in order to meet climate and sustainability goals, including the UN's Agenda 2030 SDGs, the Paris Agreement of Climate Convention, the EU Bioeconomy Strategy, the EU's LULUCF Regulation, the EU Forest Strategy (2018), and the European Green Deal. HoliSoils will develop a harmonised soil monitoring framework and identify and test soil management practices aiming to mitigate CC and sustain provision of various ecosystem services essential for human livelihoods and wellbeing. HoliSoils incorporates novel methodologies and expert knowledge on analytical techniques, data sharing, soil properties and biodiversity, and processes with model development, in order to develop tools for soil monitoring, refine GHG assessment of the LULUCF sector, enhance efficiency of GHG mitigation actions, and improve numerical forecasting of soil-based mitigation, adaptation, and ecosystem services. HoliSoils applies a collaborative multi-actor approach, in order to maximise its applicability and impact beyond its duration. The multidisciplinary consortium consists of universities and research institutes from across Europe, with leading expertise on soil analysis and databases, development of advanced analytical techniques, complex system modelling, digital soil mapping, soil ecology, disturbance ecology, forest and GHG inventories, social sciences, and communications. It also involves active engagement with diverse stakeholders, including forest owners and managers, industry actors, forest extension services, a certification body, forest and soil researchers, climate policy support and GHG inventory experts, and policymakers.

Keywords: soil resilience,soil microbiology,greenhouse gas inventory,soil modelling,soil data harmonization,forest management practices,managed peatlands,disturbances,paris agreement,lulucf regulation
Reality of a UV window during the geomagnetic excursion event of Mono Lake-Laschamps and possible link to the disappearance of the Neanderthals (REVA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

The Earth is constantly subjected to cosmic radiation, the intensity of which, at the level of the upper atmosphere and the Earth's surface, depends on the strength of the magnetic field (MF) surrounding our planet. Over geological timescales, there have been periods of collapse of the magnetic dipole moment, and therefore of the MF, which can be associated with changes in the polarity of the dipole or with simple geomagnetic excursions (GE). GE events (typically lasting ~1ka to ~10ka) generate an increase in cosmic bombardment in the upper atmosphere and, ultimately, through chemical effects the destruction/thinning of the ozone layer. During these periods UV radiation can penetrate deeper into the atmosphere, while it is otherwise absorbed by the ozone layer. Yet, the reality of such a UV "window” has never been attested by natural observations, which if present during GE events in the future would have significant environmental and above all human consequences. This is plausibly foreseen in a short term as the intensity of Earth’s MF has decreased (~20%) over the past 150 years and with an accelerated rate in the last decades (> ~10 times the normal). The aim of this project is, therefore, to test the reality of a UV window during the Mono Lake-Laschamps (~ -40 ka) GE event, which by its magnitude, its globality and the possible implications for human evolution (being contemporaneous with the disappearance of the Neanderthals), is an example of a remarkable case study. Here, by measuring stable isotopic composition of sulfur (S) at high resolution (<200 years) in ice cores taken in Antarctica, we will leverage peculiar aspects of atmospheric chemistry of the S-33 isotope. In the absence of ozone, the interaction between SO2 and UV radiation, through photochemical processes, generates mass-independent (Δ) signatures. We propose to trace a possible UV "window" by analyzing the evolution of the observed ΔS-33 anomaly and model the extent of depletion of ozone layer.

Keywords: sulfate,ozone,photochemistry,mass independent isotopic fractionation mif,antarctica,ice core
Ageing Trajectories of Health: Longitudinal Opportunities and Synergies (ATHLOS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Spain,Austria,Italy,Germany,Spain,Belgium,Greece,Poland,Sweden,Switzerland,Finland,United Kingdom,United Kingdom,United Kingdom
Call: Understanding health, ageing and disease: determinants, risk factors and pathways (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-05-01
End date: 2020-04-30
Duration (months): 60.0
Total project cost (EUR): 6139147.5
EU funding (EUR): 5943835.0
Participants: 14
Project status: CLOSED

The objective of the ATHLOS Project is to achieve a better understanding of ageing by identifying patterns of healthy ageing pathways or trajectories, the determinants of those patterns, the critical points in time when changes in trajectories are produced, and to propose timely clinical and public health interventions to optimise healthy ageing. Moreover, a new definition of ‘old age’ based on many characteristics rather than just the classical chronological definition of age will be used for calculating projections in each specific population and guide policy recommendations. To do so, the Consortium will create a harmonised dataset with over 341,000 individuals collated from existing longitudinal studies of ageing and including information on physical and mental health, biomarkers, life style habits, social environment and participation, among others. A single metric of healthy ageing using Item Response Theory (IRT) methods with individual items from the surveys will be used. Diverse statistical methods will be employed to define the trajectories (Generalised Estimating Equations, Structural Equation Modelling, Growth Curve Mixture Modelling, the TRAJ method and classification algorithms). Age Period Cohort will be used in the analysis to understand age cohort effects. Specific interventions both at the clinical and population level will be designed based on project’s results and will be disseminated. Additionally, the impact of those interventions on healthy ageing will be assessed with the micro-simulation method. Stakeholders will participate in the definition of outcomes, the creation of interventions and dissemination of results. ATHLOS will make available to scientists and stakeholders its resources by providing access to the methodology of harmonisation and to the mega-data set of ageing cohorts. To maximise the policy impact, target audiences will be indentified and specific materials disseminated.

Keywords: healthy ageing,pathways,harmonisation,longitudinal studies,life course,common metric of health,micro simulation,new definition of old age,health inequalities,physical and metal health