Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Planetary-scale indexing of sequencing data (IndexThePlanet)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1933625.0
EU funding (EUR): 1933625.0
Participants: 1
Project status: SIGNED

Nowadays a huge amount of planetary DNA and RNA sequencing data is available and continues to double every two years. However, efficiently analyzing this data is impossible due to its size measured in petabases. Many high-impact biological discoveries could be made but are prevented by the lack of fast search algorithms. I recently demonstrated this potential by discovering an order of magnitude more RNA virus species within all public RNA samples. A global index, i.e. a planetary genomic search engine, would unlock instant and inexpensive search within petabase-scale data. I hypothesize that I can create a searchable index for all of the public DNA and RNA sequencing data. Leveraging my unique expertise across algorithms and data structures for biological sequences, my plan is to design efficient methods to assemble and compress all available sequencing data, and then construct an external-memory index that will support versatile biological queries. A planetary sequencing data index will enable a myriad of bioinformatics analyses that are currently out of reach. I will demonstrate the utility of the index by constructing a database of human transcripts with novel diseases associations, discovering novel microbial species, and providing a search engine for environmental metagenomes. The resulting unprecedented collection of assembled genomes and compressed reads will lift a major challenge in data accessibility, improving its efficiency by several orders of magnitude, revolutionizing the scale of future bioinformatics analyses.

Keywords: bioinformatics,sequencing data,algorithms,indexing,k mers,compression,genome assembly
Monocyte-to-Macrophage Trajectories After Lung Injury: Spatio-temporal investigation, molecular regulation & functional implications for lung regeneration and immunity (MoMacTrajectALI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1999863.0
EU funding (EUR): 1999863.0
Participants: 1
Project status: SIGNED

The lung is particularly exposed to airborne and blood-borne insults. The mechanisms underlying lung tissue repair are therefore of fundamental biological importance and have critical implications for the prevention life-threatening inflammatory and tissue-damaging responses. Lung-resident tissue macrophages and inflammatory monocyte-derived macrophages (InfMoMac) are key players in the maintenance of homeostasis, repair responses and disease pathogenesis. Yet, to date, the complexity of lung macrophage responses after injury is far from being resolved. Here, we propose to explore InfMoMac trajectories and functional diversity in an unprecedented manner. To this end, we will use mouse models of infectious and non-infectious lung injury combined with single cell and spatial analyses, robust fate-mapping models and gene targeting approaches to investigate the spatio-temporal regulation, the subtissular niches, the intrinsic molecular programs and the extrinsic stress-, inflammation- and niche-related signals imprinting the identities and functions of InfMoMac subpopulations, and the functional consequences of the maintenance of InfMoMac for lung immunity to a subsequent challenge. Finally, we will investigate the interactions of InfMoMac with niche cells in humans by analyzing the InfMoMac landscape in human injured lungs and by studying a novel human embryonic stem cell-derived lung organoid model in co-culture with monocyte-derived cells. Based on robust preliminary data, sophisticated models and cutting-edge technologies, this ambitious project will increase our understanding of the basic mechanisms underlying the fine-tuning of InfMoMac trajectories in response to lung injuries and will thus provide robust foundations to manipulate their fate in medically relevant conditions such as severe respiratory viral infections and acute respiratory distress syndrome.

Keywords: macrophage plasticity and function lung damage and repair tissue immunity respiratory viral infection macrophage niche cell interactions epigenetic imprinting in vivo models ex vivo human organoids
Million Nautical Mile Fuel Cell System (MiNaMi)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Finland,Sweden,Norway,Greece,Italy,Romania,Denmark
Call: Reliable, efficient, scalable and lower cost 1 MW-scale PEMFC system for maritime applications (HORIZON-JU-CLEANH2-2025, 2025)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 8664214.85
EU funding (EUR): 6999953.27
Participants: 9
Project status: SIGNED

The overreaching objective of the MiNaMi project is to develop the first megawatt (MW) size Proton-Exchange Membrane Fuel Cell (PEMFC) for maritime use, with a lifetime of 80,000 hours, enabling it to operate over a million nautical miles with a speed of 12.5 knots. This megawatt-size PEMFC system and its related power electronics will be designed to function as building blocks for systems exceeding 10 MW enabling new applications for maritime fuel cells. These multi-MW FCS systems are designed using both FC simulations as well as safety and reliability modelling. The use of latest stack technology will reduce footprint of the system which increases the payload and usable volume for the fuel, cargo and passengers. The long lifetime would be enabled by optimised system designed and operation and with an advanced hydrogen and humidity sensor solution enabling optimisation of FC system control, when stack and balance-of-plant (BoP) components are aging. The system efficiency is improved with advanced BoP design and with purge optimisation, which also minimises hydrogen emissions to the atmosphere. While focus in the MiNaMi project is in maritime applications the multi-stack solutions of the project can be applied in all MW scale PEMFC applications, including trains and large working machines, such as mine trucks as well as peak power plans supporting electric grid. The results of MiNaMi enable first European PEMFC system manufacturing in MW-scale. While the benefits of the solutions developed in MiNaMi project are largest in MW scale applications, these can be used in all other applications where multiple stacks are used. The use of green hydrogen in MW scale PEMFC systems enable decarbonisation of transport sectors, where direct electrification with batteries do not provide sufficient solution. The results of MiNaMi will support Europe in keeping leading global position in the development of MW scale PEMFC systems especially for maritime applications.

Keywords: pemfc system,durability,scale up,diagnostics,simulations,accelerated stress testing,total cost of ownership,lca,european supply chain,open source software
Environmental resolution mechanisms beyond the nation state. A comparative analysis of the implementation of court judgements and managerial agreements (ENVIMP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,Japan
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 2
Project status: CLOSED

This project studies the national implementation of legal judgements from courts and managerial agreements from non-compliance mechanisms on European and international environmental issues. Against the background of the increasing impact of climate change and a lack of specialised jurisdiction over environmental disputes beyond the nation state, the implementation of legal obligations is a crucial tool to protect Earth’s environment from harm. Yet, systematic insights on the national implementation of so-called ‘resolution mechanisms’, i.e., managerial agreements from non-compliance mechanisms and court judgements on supra- and international environmental issues, are lacking. This project will investigate the conditions explaining effective implementation of such agreements and judgements by adapting insights on policy implementation research and comparing processes of implementation across different types of resolution mechanisms. It will develop an innovative, theory-driven concept-structural framework based on key conditions from the implementation literature (actor preferences, institutional legitimacy, resolution mechanisms) that mirror the existing management and enforcement approaches. The framework will enable systematic comparisons across resolution mechanisms and thus account for a diversity of separate but equally valid explanations. Empirical analysis will follow a mixed methods approach that includes (1) data gathering based on public documents and expert interviews, (2) a comparative assessment via Qualitative Comparative Analysis (QCA) including case studies, and (3) in-depth process tracing of unexpected cases identified in the QCA. This approach will provide generalisable insights on how different preferences combine with varying degrees of legitimacy and resolution mechanisms to explain the national implementation of managerial agreements and court judgements on environmental issues.

Keywords: policy implementation environmental policy environmental law judicial governance international courts enforcement non compliance mechanisms qualitative comparative analysis qca
Green Recycling Route for Sm-Co Permanent Magnet Swarf (GYROMAGS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Slovenia
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 171399.36
EU funding (EUR): 171399.36
Participants: 2
Project status: CLOSED

Permanent magnets (PM) have a wide range of applications and play an important role in the realization of a sustainable future. With the increasing demand for green and renewable energy production and sustainability, comes a rise in popularity and demand for electric vehicles (EV) and hybrid electric vehicles (HEV) which use permanent magnet-driven electric motors. However; the development of technology and shrinking dimensions of parts used for such technologies has made post-processing and machining of the bulk PMs inevitable. This, in turn, leads to a 30% waste of the magnetic material as swarf/rejects. PMs are made of a combination of Rare Earth Elements (REE), transition metals (TM) and, some other elements. The scarcity of the REEs and volatile and unstable price of the TM market (especially Cobalt) has pushed the EU to encourage scientists to come up with feasible methods to revive the mentioned waste and thus achieve a circular economy and guarantee sustainable energy production and by doing that help the EU to achieve it's Green Deal Initiative goal set for 2050. The recycling of Samarium-Cobalt (Sm-Co) permanent magnets has been the target of a number of scientific studies, however; the proposed methods are all very energy-intensive and require a lot of mineral acids, and generate a huge amount of wastewater during the process. In this proposal, we suggest a green and facile method based on electro-deoxidation of the oxidized magnet swarf which will require much less energy consumption and will require a negligible amount of acids and chemicals compared to the conventional methods.

Keywords: electro deoxidation,permanent magnet recycling,sustainability,rare earth recycling,magnetism,
Patient-specific Microstructural and radIobiological model for persoNalised external beam radiatIONn therapy in localised tumourS (MINIONS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1487676.0
EU funding (EUR): 1487676.0
Participants: 3
Project status: SIGNED

External-beam radiotherapy has been established as best practice care in different cancer cases, although current models applied in the clinics to tune the treatment plan dosimetry, as a function of the expected tumour response and radiation-induced toxicity, do not make use of patient-specific information, but rely on radiobiological parameters typically derived from in-vitro experiments, thus abdicating from describing the in-vivo complexity of the pathology. MINIONS is a cutting-edge research programme that investigates and integrates a set of activities to implement patient-specific microstructural and radiobiological models in personalized radiotherapy treatment planning and adaptation towards a detailed description of tumour characteristics of each patient and thus significantly improved tumour control probability. The main challenge of MINIONS is to create, for the first time, a real-time patient-specific model able to describe the microscopic characteristic of the tumour and its interaction with the radiation beam. The scientific activities of MINIONS are to achieve and merge: (i) Monte-Carlo (MC) simulations of Diffusion Magnetic Resonance (DW-MR) signals and radiation-tissue interactions on a library of in-silico cellular substrates to obtain an integrated simulation platform; (ii) real-time Artificial Intelligence-based techniques to accelerate MC simulations and make them compatible with fast treatment planning and adaptation; (ii) advanced DW-MR imaging, to retrieve non-invasively the information required to feed the simulation platform for the implementation of patient-specific microstructural and radiobiological models. The design of in-vivo and ex-vivo tests allows validating the model performance and the collaboration of researchers, engineers and clinicians will drive the use of this innovative strategy in clinical routine, to increase survival and quality of life for a wide range of cancer patients.

Keywords: personalised radiotherapy,microstructural and radiobilogical modelling in radiotherapy,diffusion mri in radiotherapy,monte carlo simulations in radiotherapy,artificial intelligence in radiotherapy
STormwAteR and WastewAteR networkS heterogeneous data AI-driven management (STARWARS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France,Italy,South Africa,Morocco,Viet Nam
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 1196000.0
EU funding (EUR): 1196000.0
Participants: 8
Project status: SIGNED

Public and private stakeholders of the wastewater and stormwater sectors are increasingly faced with large quantities and multiple sources of information/data of different nature: databases of factual data, geographical data, various types of images, digital and analogue maps, intervention reports, incomplete and imprecise data (on locations and the geometric features of networks), evolving and conflicting data (from different eras and sources), etc. Obtaining accurate and updated information on the underground wastewater and stormwater networks is a challenge and a cumbersome task, especially in cities undergoing urban expansion. Within this context, the main objective of this multidisciplinary project, STARWARS (STormwAteR and WastewAteR networkS heterogeneous data AI-driven management), is to address this challenge by providing novel proposals for the management of heterogeneous data in stormwater and wastewater networks. The STARWARS project aims to bring together researchers from the AI and Water Sciences communities in order to enhance the emergence of new practical solutions for representing, managing, modelling, merging, completing, reasoning, explaining and query answering over data of different forms pertaining to stormwater and wastewater networks. The project is implemented through five work packages (WP). The first four WP concern research developments of new AI methodologies for managing heterogeneous stormwater and wastewater networks’ data. The fifth WP is dedicated to project management and dissemination activities. The second objective of the project is to produce new knowledge and to promote knowledge exchange, with a strong will and a plan to encourage knowledge sharing between the researchers involved in this STARWARS project. The scheduled secondment plan is designed with the aim of maximizing knowledge transfer and training between the two fields of Water Sciences and AI and thus facilitating the achievement of the project objectives.

Keywords: wastewater and stormwater networks data,practical aggregation,uncertain data,heterogeneous information and data,data completion
The Choreographic Approach: Collaborative Applications of Embodied Practice in Music and Performance Training and Education (CHORA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland,Denmark,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2028-02-29
Duration (months): 30.0
Total project cost (EUR): 315910.8
EU funding (EUR): 315910.8
Participants: 3
Project status: SIGNED

In today's highly digitized, post-COVID world, where virtual interactions often replace human-to-human contact, society faces a critical challenge: the increasing disconnection from our bodies and a decline in direct human sensory experiences. This virtual disembodiment diminishes our capacity for empathy, emotional engagement, and social adaptability, weakening our collective ability to build healthier, more inclusive communities. To counter these trends, and in alignment with Horizon Europe’s 2023-25 focus on human-centred practices, we must promote shared, embodied experiences that primarily engage our senses and emotions. The performing arts, with their emphasis on physical expression, offer an ideal platform for fostering such engagements. The CHORA project aims to confront this issue by developing the Choreographic Approach (CA), an innovative training and teaching methodology for the performing arts, designed to promote human-centred, embodied learning in both academic and non-institutional settings. Leveraging the unique potential of the performing arts sector to engage people through shared sensory experiences, the CA integrates sound, voice, and movement into interdisciplinary exercises that foster creative, collaborative, and non-hierarchical practices. It provides a toolkit for sensory-based creation and interpretation, offering an accessible and adaptable framework for diverse educational settings. Conducted through practice-as-research (PaR) activities at the Department of Drama, Trinity College Dublin (host institution), the Department of Communications, Drama and Film, University of Exeter (secondment host), and the Nordisk Theaterlaboratorium, Hostelbro, Denmark (non-academic placement), the CHORA project will produce a practical training tool applicable across arts education, community engagement, and well-being programs.

Keywords: performance training,education,embodied research,physical theatre,musicology,interdisciplinary practice,practice as research,collaboration,voice studies,sound studies,somatic training