Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Atomically thin semiconductors for complementary field effect transistors (ATOMS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1936780.0
EU funding (EUR): 1936780.0
Participants: 1
Project status: SIGNED

Atomically thin body (ATB) semiconductors such as transition metal dichalcogenides (TMDs) hold tremendous promise for scaling modern electronics because their ultra-thin channel provides excellent gate electrostatics. Major semiconductor companies and international roadmaps for devices and systems have cited ATB TMDs for sub-1-nm semiconductor technologies beyond 2030. ATOMS will focus on developing ultra-scaled complementary field effect transistors (CFETs) based on ATB semiconductors, offering a transformative approach to address the scaling challenges of current semiconductor technology. The project aims to create ultra-short channel CFETs by optimising electrical contacts, developing ideal dielectrics, and integrating multiple pristine interfaces into the CFET structure. Key objectives are the development of clean van der Waals contacts for low contact resistance and high ON state current, fabrication of ideal semiconductor/dielectric interfaces for efficient switching, and novel engineering methods to tune the threshold voltages of both n- and p-type FETs. Additionally, the project will focus on synthesis of wafer scale monolayer TMDs, and seamless integration of all these components to achieve high-performance CFETs. By employing industry compatible fabrication processes, the ATOMS project aims to advance these technologies toward practical applications in next generation low-power electronics. This will position CFETs based on ATB semiconductors as a foundational technology for future electronic devices.
A pioneer clinical trial management system to automatically collect, review and analyse prospective clinical trial data to prompt faster development of novel therapies. (YL System)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Israel
Call: Strategic Digital and Health Technologies (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-09-01
End date: 2025-02-28
Duration (months): 30.0
Total project cost (EUR): 3566061.25
EU funding (EUR): 2496242.88
Participants: 1
Project status: CLOSED

YonaLink (YL) is an Israeli company established in 2018 with the mission to disrupt the €46B clinical research market by connecting the world of Prospective Clinical Trial Data. To this end, YL is developing the YL System, a platform to migrate clinical research data saved in the patient health records, from medical centres to research database(s) in an automated, secure, validated, trusted and error-free way. The company has secured over €1.8M in the development of the YL System, reaching TRL 7 with pilot trials implementing it at Soroka MC (Clalit Health Insurance leading hospital) and in Sheba MC. The trials have confirmed the accuracy in migrating patients’ de-identified data from the EHR to the trial DB. EIC support will allow YL to finish optimization and validate the YL System in a multicentre–multinational pilot, demonstrating the advantage of automatic data transfer from EHR to the prospective trial database to all the clinical trial stakeholders in the EU.

Keywords: data security,data transfer,data management,clinical trial,electronic health records,electronic patient files
Economic and ecological recovery of indium, gallium and germanium from industrial waste (Eco-Metalophosphore)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Hungary
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 2
Project status: SIGNED

The European Green Deal aims to achieve climate-neutral Europe by reducing greenhouse gas emissions to at least 55% below 1990 levels by 2030. The success of this target requires reliance on low-carbon technologies that are depended on the availability of critical raw materials (CRM) like indium (In), gallium (Ga) and germanium (Ge). Besides the improvement of conventional mining technologies, recycling of In, Ga and Ge from solid industrial waste is one of the beneficial alternatives to ensure the availability of CRM and meeting EU targets in future. However, the low concentration of CRM and larger presence of contaminants like Fe/Al makes the recovery of CRM from secondary resource uneconomic and technically unfeasible. Eco-Metalophosphore would overcome these challenges by applying phosphonium ionic liquid (PIL) based solvent extraction (SX) and patented GaLIophore technology to recover In, Ga and Ge from industrial wastes. PIL-based is a simple and cost-effective process for removal of Fe/Al while GaLIophore technology will be able to selectively recover In/Ga/Ge from the leachate devoid of Fe/Al and up-concentrate. Prior to PIL-based SX and GaLIophore technology, soild waste will be leached through acidic leaching. Upon successful demonstration at the laboratory scale, scale-up of the Eco-Metalophosphore technology will be carried out at 500 L/d scale. To quantify the benefits of the developed technology, life cycle assessment, ecotoxicity analysis of leach residue and generated waste and cost-benefit analysis will be carried out. To ensure the cost-effectiveness of the technology, recycling of PIL, organic acids and siderophores will be attempted. Eco-Metalophosphore contributes to circular economy and innovative green technologies initiatives that enable a sustainable, environment-friendly, and economic recovery of In, Ga and Ge from waste products.

Keywords: ecotoxicity,gallium,germanium,lca,indium,phosphonium ionic liquids,recovery,siderophore,scale up,
PERSONAL NATURAL ENVIRONMENT-GENE-GUT-BRAIN INTERACTIONS BASED ECOSYSTEM FOR PREVENTION OF MENTAL ILLNESS IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS (PUREMIND) (PUREMIND)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Italy,Ireland,United Kingdom,Bangladesh,Spain,Switzerland,Romania,Ethiopia,Greece,Germany
Call: Towards a holistic support to children and adolescents’ health and care provisions in an increasingly digital society (HORIZON-HLTH-2024-STAYHLTH-01-two-stage, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 11026633.5
EU funding (EUR): 9845662.72
Participants: 26
Project status: SIGNED

PUREMIND will deliver the first Integrated Mental Healthcare Ecosystem (IMHE) to predict/early identify Mental Health Disorders (MHD) and create more optimal personalised interventions to prevent MHD and thereby improving wellbeing in children, adolescents, and young adults (0–25 years). The ecosystem will mitigate key challenges associated with MHDs, specifically 1)Detection: 1 in 7 undetected and untreated MHD cases, 2)Efficiency of treatment: lack of tools and guidelines for personalised multidisciplinary interventions that work, 3)Access to Support and Care: long waiting times for care due to lack of trained personnel, 4)Inequality: disparate and inadequate inter- and intra-country mental healthcare services and 5)Modern Cultures and Lifestyle: the increasingly recognised risk factor of digital addiction resulting in sedentary, socially isolated lifestyle contributing to MHD. These will be addressed by PUREMIND’s approach of combining analytical modelling of dynamical systems in the cyber-physical context of a subject’s personal natural environment-gene-gut-brain-MHD interactions process creating a much-needed personalised intervention synthesis framework that will be exploited by an AI engine to deliver optimised personalised intervention, and a unique digital twin educating young people how MHD might develop depending on their environment and lifestyle. These 2 components will be combined in an accessible/ adaptable mobile app MyMind to measure at scale and allow a subject to seamlessly access a 4-tier service architecture involving family, community, clinical and emergency services, to support prediction/early detection of MHD, empowering them to monitor their own mental health at home/educational/community settings and taking preventive actions against MHD. The IMHE will be designed using Implementation Science approach and will be validated in a 12month pilot study in 7 European countries and 2 LMICs covering different socioeconomic and cultural scenarios.

Keywords: mental health disorders in children adolescents young adults patient empowerment digital twin
Deciphering the role of RNA biological noise in aging using long-reads transcriptomics. (RBNAGE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: SIGNED

The ultimate goal of this proposal is to decipher the role of the RNA biological noise (RBN) in the ageing brain. RBN represents a rare but real pool of RNA molecules generated as a result of transcriptional instability. However, as the RBN can only be extracted by full-length single-molecule transcript sequencing, whether RBN is associated with decline processes such as aging and neurodegeneration, remains to be elucidated. To evaluate this association, I will use readily-available data, including long-reads, single cell and spatial transcriptomics of aging mice brains. First, I will develop a methodology to distinguish technical noise from RBN in long-reads transcriptomics. Second, I will characterize the RBN to decipher its contribution to aging. Third, I will study the cell-type-specific and brain-region-specific RBN. To carry out this project, I will work with Dr. Conesa, expert in long-reads transcriptomics, method development and multi-omics. This timely work will benefit from collaboration with world leaders in single-molecule technologies participating in MSCA-DN 2021 “LongTREC” to study transcriptome biology under the coordination of Dr. Conesa. Successful completion of this project will contribute insights and software to understand the RBN across the single-molecule transcriptome, not only in the context of aging and neurobiology but also for researchers to use in other biological contexts. This project could also set important first steps towards better health, healthy aging, and a decrease in avoidable neurodegeneration.

Keywords: aging,neurobiology,long reads transcriptomics,modelling,biostatistics,bioinformatics
Philosophy of Social Physics (SOPHY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-02
End date: 2025-10-01
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

"Philosophy of Social Physics" (SOPHY) intends to explore the impact of physics on the genesis of the social sciences and to define the current use of “Social Physics” in the scientific discourse on big data related to crowd behaviors. The general hypothesis is that physical narratives and notions such as force, resistance, balance, and average have played a crucial role in shaping the concepts we use to think of society since the rise of the Sociological thought in the 19th century, and that in reconstructing the genealogy of the social sciences, the reference to natural sciences cannot be limited to the biological framework. The goal is to provide new insights into the conceptual paradigms that have been underpinning democratic governance in modern and contemporary societies, thus raising awareness about the rationale of increasingly data-based patterns in social policies. The "Social Physics" paradigm has not yet been analysed in depth through a political-philosophical perspective capable of showing the internal logic and history of the concepts employed. Additionally, an analysis of the links between physics-related notions and political and social concepts in the 19th century is still to be outlined. Moreover, there is still no historical, conceptual, and philosophical-political study focusing on the origins of social physics as it is understood and structured today. SOPHY will use a methodology resulting from an original combination of the tradition of Begriffsgeschichte, Foucauldian discourse analysis, Historical Epistemology and History of social concepts. This methodology will allow to analyse the historical semantics of concepts emphasizing their contingency and their cultural and social constructed nature, while defining at the same time the epistemic structure in which they are produced and used.

Keywords: social physics quetelet saint simon comte sociological thought conceptual history begriffsgeschichte physics society data governance
Innovative practices, tools and products to boost soil fertility and peat substitution in horticultural crops (SPIN-FERT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Innovation actions
Countries involved: Poland,Italy,United Kingdom,Germany,Netherlands,France,Austria,Spain
Call: Soil-friendly practices in horticulture, including alternative growing media (HORIZON-MISS-2023-SOIL-01, 2023)
Start date: 2024-06-01
End date: 2027-11-30
Duration (months): 42.0
Total project cost (EUR): 7092190.0
EU funding (EUR): 6497816.14
Participants: 20
Project status: SIGNED

The main objective of SPIN-FERT is to integrate optimised and validated innovations in soil management practices and improve peat-free substrates to enhance soil health in vegetable, fruit and ornamental crops. SPIN-FERT will exploit outcomes, including patents, from several related projects, in particular EXCALIBUR as 6 of its members are partners in SPIN-FERT. Multi-actor approach is at the core of SPIN-FERT methodology and consortium for extensive knowledge transfer and co-design. Specifically, SPIN-FERT will optimize the production process of chosen fertilising products and improve their formulation with innovative protocols to increase efficacy. SPIN-FERT will leverage agro-food by-products into resources for agricultural production, exploiting them further into peat-free substrates. These and reconditioned coir will be formulated with specifically selected microbial strains to improve their characteristics and applicability, particularly for nursery industry. All innovative products will be validated in field trials in 4 regions in Europe (PL, I, F and UK). Five tools will be delivered to support the correct implementation of the practices, to facilitate products registration and favoring policy development, including a Soil Holistic Quality Index. SPIN-FERT will carry out economic, social and environmental assessments of the peat-free substrates and soil management innovations, to demonstrate sustainability. All this information will serve to develop a comprehensive policy framework for measures fostering wide adoption of soil-friendly practices. To further ensure commercial relevance of the peat-free substrates and soil management innovations, SMEs, public authorities and citizen representatives partner or advise on SPIN-FERT for effective project delivery and maximum impact. Art&science and image-based tools will be utilized in communication and dissemination to increase awareness on the central role of soil health for humans and planet living.

Keywords: fertilising products
Understanding the impact of environmental POLlution on the adaptive Immune System (POLIS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 1499749.0
EU funding (EUR): 1499749.0
Participants: 1
Project status: SIGNED

There is growing evidence that currently used toxicological assessments of chemicals fail to fully capture their actual biological activity. While chemicals are routinely tested for acute toxic effects, often at high concentrations, potential function-modulating effects at low concentrations are often underexplored. The inclusion of up-to-date high-resolution methods in the toxicological screening praxis would allow instead to fully capture the complex bioactivity profile of these compounds, which depends on numerous aspects including bioavailability, route of exposure and individual susceptibility. While the last 100 years have seen an enormous number of chemicals introduced into our daily life, of which a large number are well-known to persist in the environment, a sufficient understanding of their bioactivity potential is lacking. Also based on growing evidence, it is not far-fetched to hypothesize that some of these industrial chemicals could be partly responsible for the constant increase of non-communicable diseases including autoimmune diseases, chronic inflammatory diseases but also cancer or (neuro)degenerative diseases. Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) are a class of xenobiotics with proven strong toxicity at high-level exposure, while little is known about their bioactivity at concentrations commonly detected in human samples. Considering their high stability and ubiquitous occurrence in the environment and human body, exposure to PFAS has reached a pandemic scale. I postulate that it is of outmost importance to finally dissect the potential of these compounds to molecularly interfere with organ functionalities at the single-cell level using state-of-the-art high-resolution omics technologies. Supported by an interdisciplinary training in pharmacology, systems immunology, omics, animal and cellular models, and bioinformatics, I represent a prime candidate to successfully develop this project and clarify the bioactivity of PFAS.

Keywords: pfas,environmental pollution,chemical bioactivity,forever chemicals,systems immunology,adaptive immunity
Gentlemen and Caballeros: a transnational analysis of nineteenth-century masculine honourability (MASChonourability)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-20
End date: 2027-10-19
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: CLOSED

This pioneering research takes a unique approach to analyse the male gender identity of the upper and middle classes in Spain, Cuba, Ireland, and England during the nineteenth century. The project proposes a comparative study of male honour and its associated practices among the dominant classes in these four countries. The concept of honour was a powerful symbol of respectable masculinity, encompassing moral virtue, social and political precedence, the mandates of self-control for men, patriarchal power in the family, and legitimate use of violence. The analysis of honour thus provides an exceptional means of understanding the normative masculinity of the social elite. This project will investigate a little-explored topic by historiography, the shared and distinguishing aspects that defined the manliness of the self-appointed gentlemen (in England and Ireland) and “caballeros” (in Spain and Cuba) relying on a transnational approach. So far, research has analysed male honour in each nation separately, without considering enough the nuances that defined it in each territory. Moreover, how the gentlemen of these countries mutually aligned themselves as equals in honour and respectability has also yet to be studied. Additionally, the issue of “race” has not been sufficiently considered in previous studies on elite male honour. With its interdisciplinary approach, this project aims to analyse all these crucial aspects to complicate our understanding of middle and upper-class masculinity in the nineteenth century, along with the overall gender relations and the incumbent political and social context. In this way, we will gain a deeper understanding of the structural nature and historical roots of the violent and discriminatory practices based on gender, race, and class that persist nowadays, helping to eradicate them. This work will focus on the ritual of duelling, which was the most emblematic practice of the male code of honour since the Middle Ages.

Keywords: masculinities,honour,elite cultures,transnational history,race