Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Afterlives of Contract and Enslavement: Narratives on Indentured Labour between Cape Verde and S. Tomé and Príncipe (GHOST)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Portugal,Cabo Verde,Sao Tome and Principe
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-04-01
End date: 2027-03-31
Duration (months): 36.0
Total project cost (EUR): 217245.6
EU funding (EUR): 217245.6
Participants: 3
Project status: SIGNED

This project provides the first comprehensive study on the entangled cultural memories of plantation' indentured labour under Portuguese colonialism in Cape Verde and S. Tomé and Príncipe, from the 20th century onwards. GHOST addresses a gap in global plantation studies, predominantly focused on the Americas, by exploring how and why the narratives of indentured labour, known as contrato, change over time in these two African archipelagos. Drawing on original and detailed empirical research, GHOST analysis is based on a diverse set of visual, oral and written sources – among others, literary texts, music, cinema, interviews, newspapers articles, photographs, letters, laws, reports (and other official documentation) – through which the project will trace the multiple and sometimes divergent Cape Verdean and Santomean narratives linked to plantation work and contrato, how they are mobilized, and their changing symbolic and political uses through time. The originality of this project derives from a ground-breaking interdisciplinary approach to colonial indentured labour underdeveloped experiences using the conceptual framework of haunting. It argues for three distinct readings of ghosts and hauntings: as spectral agents – or the return of the dead as spirits – that, by transcending fixed boundaries of time and space, through ritual possession or other mechanisms, can disrupt dominant narratives of the past; as a rhetorical device for addressing colonial violence and its persistent legacies in the present, discussing notions of historical injustice and representation; and as an active process of ghosting concrete subjects, regarded as unworthy of social recognition, by disqualifying and dehumanizing them. Suggesting a move towards decolonising haunting, the project, interdisciplinary in nature, enables a critical dialogue between memory studies, cultural history and postcolonial theories, contributing to contemporary efforts of decolonising colonial-imperial pasts.

Keywords: haunting,postcolonial memory,plantations labour,portuguese colonialism,epistemologies of the south
Political Trust in Crisis: Determinants and Solutions (POLTRUSTLAB)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 1836250.0
EU funding (EUR): 1836250.0
Participants: 1
Project status: SUSPENDED

In the last years, the world has experienced an unprecedented increase in the fraction of people that have lost their confidence in political institutions and have started supporting populist candidates. While a rapidly growing literature in social sciences has investigated this phenomenon, current research methodologies face important limitations. Existing studies have limited measures of political attitudes and provide little evidence on the mechanisms behind the increase in distrust. In this project, I propose a radically different approach to tackle this question. I plan to conduct extensive data collection through online surveys in multiple countries and periods. I will combine this novel data with extensive use of survey experiments and quasi-experimental approaches. This methodology has the potential to significantly expand the research frontier in the study of political discontent. First, I plan to collect the most detailed individual-level panel dataset on perceptions, beliefs, and attitudes. Second, the use of survey experiments provides a unique toolkit uncover the ?mental model? of individuals (i.e., their modes of reasoning that generate a link between a shock and ultimate political discontent). This novel methodology will be applied to answer two main questions: (1) What are the fundamental drivers of political discontent? I will examine the effects of a number of different economic and cultural shocks on discontent and distrust. In the uncovering of the mechanisms, I will pay special attention two key mediating factors: the policy response to shocks of traditional parties and the exposure to populist and nativist narratives. The second research question is: (2) How can trust in the political system be regained? Using a number of experimental and quasi-experimental designs, I will investigate whether exposure to safety-net policies can help individuals to regain trust in the political system.

Keywords: trust,populism,mental model,political attitudes
Multidisciplinary Integration and Networking for INcreased sustainability and multi-resources valorization of Geothermal Brines (MiningBrines)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,Germany,Türkiye,Italy,Croatia,Serbia,Sweden,Switzerland,Belgium,United Kingdom,United States
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 4368520.8
EU funding (EUR): 4368520.8
Participants: 32
Project status: SIGNED

MiningBrines offers an innovative training program to address Europe's strategic need for sustainable access to critical raw materials (CRM), energy gases (EG) and renewable energies. 19 Doctoral Candidates (DCs) will receive interdisciplinary training in geosciences, biogeochemistry, artificial intelligence (AI), and socio-economic analysis, equipping them with advanced skills in reservoir modeling, machine learning and biogeochemical processes. DCs will develop intuitive fluid chemistry modeling workflows and innovative multi-criteria intelligent decision support tools, preparing them to drive innovation in geothermal brine mining while collaborating with academic and industrial partners. MiningBrines introduces novel techniques to maximize geothermal multi-resource recovery while minimizing environmental impact. Key innovations include microbial-driven CRM recovery, customized modeling workflows, scalable AI models, and decision support tools that consider technological, economic, and societal aspects. These advances aim to reduce the environmental footprint of resource extraction and align with the sustainability goals of the EU Green Deal. MiningBrines supports the EU's Critical Raw Materials Act by combining CRM and EG recovery with renewable energy production and circular economy principles, reducing Europe's import dependency and strengthening resilience. In addition, MiningBrines emphasizes collaborative education to meet the growing demand for skilled professionals capable of transforming geothermal multi-resources into a key driver of Europe's green transition. The impact of MiningBrines goes beyond scientific advances, fostering a skilled workforce for academic and industrial sectors, while establishing Europe as a global leader in sustainable resource management. MiningBrines promotes public awareness of the multiple benefits of geothermal energy, setting a standard for green industrial practices and long-term strategic autonomy.

Keywords: fluid rock interaction processes,geochemistry and geophysics,laboratory experiments,reservoir engineering computational workflows,socio economics,environmental impact assessment
Understanding and preventing the impact of endocrine disruptors on the hypothalamus-pituitary axis in sensitive populations (HYPIEND)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: Research and Innovation actions
Countries involved: Spain,Netherlands,Belgium,Sweden,Poland,Italy,Switzerland,United Kingdom
Call: Health impacts of endocrine-disrupting chemicals: bridging science-policy gaps by addressing persistent scientific uncertainties (HORIZON-HLTH-2023-ENVHLTH-02, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 6694438.25
EU funding (EUR): 6694438.25
Participants: 14
Project status: SIGNED

Exposure to multiple endocrine disrupting chemicals (EDC) is an environmental insult that interferes with the development and function of the endocrine system, governed by the hypothalamus-pituitary (HP) axis. This interaction is specially concerning in developmental stages of life, such as the perinatal period and puberty. Despite the current body of knowledge on EDC actions on the endocrine system, a comprehensive, holistic understanding of the impact on the HP axis is still lacking. HYPIEND aims to understand the effects of EDC co-exposure in the function and epigenetic programming of the HP axis to delineate interventional strategies for minimizing exposure and consequences on the neuroendocrine system during the perinatal and pre-pubertal stages. To do that, a computational toxicology methodological framework will be built leveraging public data and state of the art data analysis techniques to define EDC co-exposure patterns in target population. The resulting patterns will be evaluated in a sequential tiered approach consisting in cell-based screenings, Danio rerio models of HP axes, in vitro, in silico and in vivo models of placenta and blood brain barrier diffusion and new models of organoids-based organ-on-chip recapitulating the HP axis. EDC effects on epigenetic programming will be evaluated in preclinical models of perinatal and early childhood. Whole genome DNA methylation patterns in the different models will be explored as a source of non-invasive biomarkers of HP axis disruption by EDC. The knowledge generated in preclinical models will be applied in two multi-centre-controlled intervention studies intended to minimize exposure to EDC in children in the perinatal and pre-puberty stages. HYPIEND outcomes will be novel approach methodologies based in in vitro and in silico models, non-invasive biomarkers of HP disruption by EDC and new intervention strategies to minimize EDC exposure in sensitive population.

Keywords: 1000 days,prepubertal children,behavioural strategies,organoids,preclinical models,risk assessment,new approach methodologies computational toxicology epigenetics hypothalamus,neuroendocrine
Modulating immune responses to mitigate neuroinflammation, bioenergetic decrease and cognitive decline in Alzheimer’s disease (immuno-ALZ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Luxembourg,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 266684.16
EU funding (EUR): 266684.16
Participants: 2
Project status: SIGNED

Background and rationale: Alzheimer's disease (AD) is the main cause of dementia, with substantial socio-economic burdens. Due to the absence of a cure, understanding disease mechanisms and developing new therapies is crucial. Age-related systemic and brain inflammation contributes to cognitive decline. Inhibiting prostaglandin 2 (PGE2) - PGE2 receptor 2 (EP2) signalling has restored youthful hippocampal functions in ageing mice, but its specific impact on AD-related deficits remains unclear. Aim: We seek to explore the effect of EP2 inhibition on bioenergetic and cognitive decline in an amyloid precursor protein knock-in (APP-KI) mouse model of AD, using neurobiology, immunology and data science. Objective 1: We will compare the effects of brain-penetrant and non-brain-penetrant EP2 antagonists on memory, synaptic function, glucose metabolism, systemic/brain inflammation and amyloid-beta (Aβ) pathology. Objective 2: We will study these effects in APP-KI mice injected with AD brain-derived pathological tau. We will then assess the impact of peripheral immune modulation on AD-like pathology spread. Objective 3: We will analyse the changes and interplay among synaptic dynamics, microglial activity, Aβ/tau pathology progression after EP2 inhibition via real-time imaging. Methodology: The study will involve various assessments, including behavioural tests, biochemical and immunohistochemical analyses, multianalyte assays, as well as multi-omics approaches that combine transcriptomics and metabolomics. Additionally, it will utilise two- and three-photon microscopy for live imaging. Expected results: We anticipate gaining valuable insights into a) PGE2-EP2 inhibition effects on AD-driven deficits, and b) whether peripheral immune re-programming restores brain functions beyond the blood-brain barrier. Impact: The project could yield novel mechanistic and translational outcomes, guiding non-invasive therapeutic approaches to combat AD through peripheral modulations.

Keywords: alzheimer s disease,neuroinflammation,bioenergetics,pge2 ep2,tau,amyloid beta,peripheral immune responses
Evolutionary Solutions for Realising a Holistic Safe System Approach for All Road Users (EvoRoads)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Countries involved: Belgium,Greece,Spain,Denmark,Sweden,Latvia,France,Italy,Romania,Cyprus,Switzerland
Call: Better infrastructure safety on urban and secondary rural roads throughout a combination of adaptable monitoring and maintenance solutions (HORIZON-CL5-2023-D6-01, 2023)
Start date: 2024-05-01
End date: 2027-04-30
Duration (months): 36.0
Total project cost (EUR): 4992381.25
EU funding (EUR): 4992381.25
Participants: 20
Project status: SIGNED

The successful implementation of EU’s 2021-2030 road safety policy is a milestone towards the target of zero fatalities in road transport by 2050 and requires a clear understanding of criteria that influence safety performance, development of solutions that promote safety for all road users, the modernisation of existing infrastructure monitoring approaches and the adoption of methodologies that take into account complex user behaviours. EvoRoads aims to accelerate the attainment of the Vision Zero EU goal through a holistic framework of innovative models, tools and services that enable data-driven evolution of safety assessment frameworks, facilitate dynamic monitoring of cyber-physical infrastructures and promote the proactive warning for safety risks in complex environments. At the operational level, EvoRoads defines safety criteria and KPIs quantification methodologies covering the entire spectrum of the “Safe System” approach and develops a connectivity platform where transport infrastructure assets are digitalised and safety assessment services are functioning in a harmonious way. Advanced AI-driven analytics for fusing infrastructure monitoring data at different geospatial resolutions, on-the-edge sensory and communication technologies for local infrastructure monitoring, a dynamic evaluation of infrastructure readiness solution in supporting the operation of CCAM, a road maintenance diagnosis and prognosis tool, and low-cost smart signs with integrated electronics and embedded components for elicting desirable user behaviours are developed. The approach is validated at 7 locations in Spain, Italy, Latvia and Romania, addressing different types of infrastructure settings and road users in urban and rural environments. Interaction with existing programmes on roadmapping and recommendations at national, EU and global level will be promoted, allowing a multiplication effect of project’s results.

Keywords: safe system approach infrastructure monitoring dynamic safety assessment framework digital twin smart road equipment predictive maintenance infrastructure readiness for ccam
Decoding the Multi-facets of Cellular Identity from Single-cell Data (DecodeSC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1484125.0
EU funding (EUR): 1484125.0
Participants: 1
Project status: SIGNED

Advances in technologies that measure gene expression at single-cell resolution have revolutionized our understanding of the heterogeneity, structure and dynamics of tissues and whole organisms in health and disease. Yet, in most single-cell experiments tissue structure, temporal trajectories, and their underlying mechanisms are lost or not directly accessible. Despite experimental advances, major gaps remain in understanding how tissues orchestrate multicellular functions. In recent years, we and others focused on computationally recovering single facets of single-cell data, such as tissue structure or differentiation trajectories. However, each cell encodes multiple layers of information about its type, location, and various biological processes. Disentangling these signals from large-scale, high-dimensional single-cell data is a major challenge. Building on my expertise in network reconstruction, probabilistic spatial inference and spectral analysis of single-cell data, I will take a unique approach to this challenge by developing computational methodologies combining machine learning and dynamical systems approaches to: (1) tease apart multiple cellular facets encoded in single-cell data; (2) infer interactions between these facets and mechanisms shaping spatiotemporal expression across them; (3) derive generative models to sample and predict unobserved cell states and design optimal perturbations, providing an interpretable platform to study conditions leading to a physiological disruption and therapies aimed at reversing it. My research program will tackle the core challenge in the single-cell era - transforming this exponentially growing, complex data into insight and principles for the underlying biology of multicellular systems. It will advance our understanding and control of collective tissue behavior, and uncover the multiple facets of cellular identity in health and disease, and thus expected to be valuable for both basic and translational research.
Frugal Zero-Emission Vehicles for the Urban Passenger challenge (ZEV-UP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Innovation actions
Partnership: 2ZERO (co-programmed)
Countries involved: Belgium,Türkiye,France,Slovenia,Hungary,Greece,Italy,South Africa,Pakistan,United Kingdom
Call: Frugal zero-emission vehicles concepts for the urban passenger challenge (2ZERO Partnership) (HORIZON-CL5-2023-D5-01, 2023)
Start date: 2024-01-01
End date: 2027-06-30
Duration (months): 42.0
Total project cost (EUR): 12580906.25
EU funding (EUR): 9619202.63
Participants: 20
Project status: SIGNED

While Fully electric vehicles (EV) have zero tailpipe emissions and are seen as a key solution to meeting the European Fit-for-55 target of reducing CO2 levels in 2030 and climate-neutrality by 2050, much more can be potentially achieved if the global market uptake of innovative EVs is accelerated. The ZEV-UP project aims to address this urgent need by developing modular, cost-effective, and user-centric EVs for both passenger and goods transportation. Leveraging innovative design and engineering techniques, ZEV-UP vehicles will be tailored to meet the specific needs of users in both developed and emerging markets, ensuring high levels of user acceptance and market uptake. Key innovations include a base L7e BEV model that is designed respectful of affordability and can be upgraded and adapted for various purposes and needs, including commercial applications and higher-value passenger vehicles. By optimizing vehicle components for reduced material usage and enhanced structural properties, the project will achieve lighter vehicles with increased autonomy and minimized environmental impact. ZEV-UP will also develop digital-twin models to improve vehicle development efficiency and reduce validation costs, as well as designing charging capabilities compatible with a variety of regional power systems. Novel business and usage models, such as Battery as a Service, will be explored to maximize the benefits and impact of the L7e BEV platform. User-centric design, informed by market research and field interviews in both established and developing countries, will be a central focus of the project. Additionally, ZEV-UP will develop a proliferation model to assess policy intervention scenarios and strategize for short- and long-term BEV uptake in various markets. By delivering these key results and adhering to its objectives, ZEV-UP will accelerate the transition to sustainable urban mobility and contribute to the reduction of greenhouse gas emissions in the transport sector.

Keywords: zero emission,electro mobility,urban,passenger