Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
From harassing to harnessing beta-cells in type 1 diabetes (Beta-STEALTH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Type 1 diabetes (T1D) is generally believed to result from a mistake by the immune system leading to the autoimmune destruction of insulin-producing β-cells in the pancreatic islets of Langerhans. Based on my discoveries, I recently began to realise that the ‘mistake’ actually occurs in stressed β-cells, leading to the generation of neoantigens resulting from ribosomal infidelity (DRiP) that provoke the immune system to act. The immune system may actually respond with ‘good’ intentions, similar to the response to such neoantigens generated upon infection and in cancer. This could explain why immune intervention therapy alone has been quite disappointing in T1D, where the loss in β-cell function could at best only be delayed. I contend that we will need β-cell therapy for a durable intervention or even remission, likely in concert with immunotherapy, to keep β-cells from provoking the immune system. Thus, I propose to explore β-cell stress, autoimmunity, resilience and function in three levels: Pathogenesis: understand the association of protective insulin gene variation with reduced β-cell stress and immunogenicity; explore the nature and function of β-cell stress product DRiP in β-cell development, heterogeneity, function and destruction; Diagnostics: target DRiP to detect β-cell stress, immunogenicity and destruction; monitor autoimmunity to DRiP by islet autoreactive T-cells or autoantibodies; Therapeutics: develop targeted delivery of drugs to distressed β-cells to foster recovery, mass and function and increase their stamina; restore immune tolerance by selective immunotherapy with islet neoantigens; generate a novel source of stem cell derived β-cells that have been equipped with resilience and superior function by gene-editing to reduce both stress and generation of neoantigens. Through these objectives, I intend to eliminate the reasons for the immune system to harass β-cells by harnessing β-cells and turn these invisible (‘stealth’) to the immune system

Keywords: type 1 diabetes immuno pathogenesis autoimmune disease islet transplantation immunotherapy genetics regenerative medicine stem cell therapy
UpstreaM synergIes to overcome Locked-in effects in widEning regions and broaden internationalization pathwayS for susTainable innOvatioN and compEtitive grant applications (MILESTONE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Life Sciences
Countries involved: Greece,Slovenia,Czechia,France
Call: Pathways to Synergies (HORIZON-WIDERA-2023-ACCESS-04, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 1199411.25
EU funding (EUR): 1199411.25
Participants: 4
Project status: SIGNED

MILESTONE will attempt to establish strong collaboration links among three widening academic institutes from Greece (UPAT), Slovenia (NIC), and Czech Republic (MU), as well as with an advanced partner (AMU, FR), to overcome locked-in institutional effects, build synergies and create a pathway to excellence, producing new knowledge in antiviral research and pandemic preparedness. UPAT, NIC, and MU, all acknowledged national/regional research actors funded by ERDF, share common interests in biosciences and will collaborate with a world-class expert in biochemistry, virology, and infrastructure management, the AMU. The MILESTONE strategy seeks to internationalise widening partners to boost their access to EU R&I consortia in joint applications under Pillars I & II, as well as to unlock, reinforce, and improve the utilization of existing R&I capacity. A key project module is training, knowledge sharing, and the acquisition of transferable skills for R&I personnel to increase performance in research, research management, fund-raising, and communication. MILESTONE’s implementation is based on well-designed WPs with specific tasks and roles for each partner to have a large impact at the scientific, societal, and economic/technological levels, and to increase the competitiveness and reputation of all partners in the direction of future sustainable development. Furthermore, MILESTONE is guided by the principles of gender equality, open research and data management. Project progress will be communicated to all prospective stakeholders as well as the public through e-communication channels and live events. Overall, MILESTONE aims to establish an effective collaborative network among participating partners to achieve synergies between Horizon Europe and cohesion policy programmes (ERDF, Interreg), to allow widening partners to catch up in their R&I performance and to reduce the innovation gap among EU regions.

Keywords: life sciences,infrastructures,internationalisation,competitiveness and reputation,access to excellent,improve reserach and transferable skill,virology
Smart design of well-function algae-plant-based powder: green spray-drying, characterization and rehydration (ALGAPOW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: SIGNED

Algae protein and plant protein are considered as novel and primary source of protein for the human being in future as it is now crucial to reduce our dependence on animal-based protein, notably to reduce greenhouse gas emissions. Also, among varied food structure, the powder matrix of the algae-plant-based formula will reduce transportation and storage costs due to lower water content, which is interesting for food industry. Moreover, the algae-plant-based powder can be a replacer to traditional dairy powder, which is namely milk-analogue powder. However, the formula of algae-plant-based solution and its powder has not been studied yet. This project therefore aims to 1/investigate the powder matrix of algae-plant based formula influenced by drying protocol, 2/demonstrate the rehydration profile of the powder matrix, and 3/improve the sustainable production of this powder. Technological and health potentiality of plant and algae protein for the production of functional food powders by spray drying will be investigated focusing on milk-analogue powder as a model. To achieve the sustainability of the process, mass and energy transfer will be modelled to identify optimal conditions for greener production. The physical characteristics of algae-plant-based initial liquid feed and final powder will be investigated. Both are linked and are of great significance on the development of powder structure during drying and on the final powder functional properties. Especially, the rehydration of algae-plant-based powder will be studied stepwise in comparison with the characteristics of feed solution and spray drying conditions, which can enlighten the smart design of powder matrix for instant breakage during rehydration. Lastly, the digestion of algae-plant-based powder and nutrition analysis pave path to alternate the real milk. As a fresh researcher, my career can be facilitated by this advanced research at AgroParisTech, internationally recognized institute on future food.

Keywords: algae protein,powder matrix design,green drying,powder digestion
ArTisanal productions in EarLy Iron AgE PRotourban centres of North Adriatic Region (ATELIER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Slovenia,Croatia
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-07-07
End date: 2027-07-06
Duration (months): 24.0
Total project cost (EUR): 155559.36
EU funding (EUR): 155559.36
Participants: 3
Project status: SIGNED

Between the end of the 9th and the beginning of the 7th centuries BC, the Veneto and Friuli Venezia Giulia regions (Northeastern Italy), as well as Slovenia, were involved in a significant process referred in literature as "Proto-urbanization". During this period, a revolutionary territorial, political, and social rearrangement is attested, achieved through the strong competence of communities and their ruling elites in managing resources and establishing permanent intercultural and extraterritorial networks. ATELIER is the first large-scale, "no-borders" and systematic research project focus on the analysis and the comprehension of the role, importance, and structure of the artisanal productive framework within the Early Iron Age Protourban centers of the North Adriatic region and its impact on the subsequent socio-cultural and economic landscape. This research aims to provide new insights into the crucial phase of establishment and consolidation of Protourban centers by investigating the specific characteristics associated with artisanal production, identifying the principal "models of production" through the analysis of craft specializations and resource management systems. By examining the patterns of distribution and circulation of goods within and beyond the communities involved in this phenomenon, ATELIER project will identify networks and exchange trajectories that facilitated trade, interactions, and horizontal mobility in this area, strongly connected both in geographical and cultural perspectives. The interdisciplinary approach adopted by ATELIER, integrating traditional archaeological methodologies with archaeometry and spatial/landscape analysis, will be fundamental for reconstructing the historical, territorial and economic-productive scenario of the Early Iron Age.

Keywords: early iron age protourban sites artisanal production trans regional connections
Electrons to Iron: green iron powder production via low-temperature electrolysis (EcoIron)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-04-01
End date: 2031-03-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

We are on the eve of a worldwide ironmaking transition. Low-temperature electrolysis (/electrodeposition) for ironmaking has recently received increasing attention as it makes direct usage of (renewable) electricity. One problem, fundamental understanding of metal electrodeposition is largely lacking. Nobody truly understands the process. With EcoIron I want to devote my knowledge in experimental and numerical chemical engineering process to the challenge of leveraging the state-of-the-art metal electrodeposition science. Such knowledge has a huge application potential in green steel production and iron-based energy storage. Four work packages (WP) are outlined: 1.to determine the governing mechanism and kinetics of oxide-to-iron electrochemical transformation from systematic experiments and characterization. The outcome will close a long-lasting scientific debate on dissolution-redeposition vs. solid-state reduction mechanism. 2.to unveil the mechanism and conditions for formation and microstructure evolution of iron dendrites using advanced X-ray visualization techniques. The impact of this groundbreaking knowledge stretches beyond the metal production community to the rechargeable battery community. 3.to clarify the roles of particle-bubble transport and species-current transfer via advanced CFD-electrochemical coupled modelling, offering strategies to enable faster conversion. This will lead to a breakthrough in metal electrowinning technologies and an advanced numerical tool for the scientific community. 4.to demonstrate a novel process for continuous production of electrolytic iron powder. This unites, translates, and validates the scientific knowledge from WPs1-3. The combined outcomes in this project constitute a breakthrough in the metal electrodeposition science. EcoIron is a beginning, which lays a robust foundation for more inclusive scientific and technological advance in the field on electrolysis for metal production to drive the sustainability

Keywords: metal fuels,electrowinning,iron powder,alkaline electrolysis
Everything You Always Wanted to Know About the JKO Scheme (EYAWKAJKOS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2182250.0
EU funding (EUR): 2182250.0
Participants: 2
Project status: SIGNED

The project deals with the so-called Jordan-Kinderlehrer-Otto scheme, a time-discretization procedure consisting in a sequence of iterated optimization problems involving the Wasserstein distance W_2 between probability measures. This scheme allows to approximate the solutions of a wide class of PDEs (including many diffusion equations with possible aggregation effects) which have a variational structure w.r.t. the distance W_2 but not w.r.t. Hilbertian distances. It has been used both for theoretical purposes (proving existence of solutions for new equations and studying their properties) and for numerical applications. Indeed, it naturally provides a time-discretization and, if coupled with efficient computational techniques for optimal transport problems, can be used for numerics. This project will cover both equations which are well-studied (Fokker-Planck, for instance) and less classical ones (higher-order equations, crowd motion, cross-diffusion, sliced Wasserstein flow...). For the most classical ones, we will systematically consider estimates and properties which are known for solutions of the continuous-in-time PDEs and try to prove sharp and equivalent analogues in the discrete setting: some of these results (L^p, Sobolev, BV...) have already been proven in the simplest cases ; the results in the classical case will provide techniques to be applied to the other equations, allowing to prove existence of solutions and to study their qualitative properties. Moreover, some estimates proven on each step of the JKO scheme can provide useful information for the numerical schemes, reducing the computational complexity or improving the quality of the convergence. During the project, the study of the JKO scheme will be of course coupled with a deep study of the corresponding continuous-in-time PDEs, with the effort to produce efficient numerical strategies, and with the attention to the modeling of other phenomena which could take advantage of this techniques.

Keywords: optimal transport,gradient flows,functional inequalities,network simplex,diffusion
Environmental Histories of Resource Extraction in Africa: Understanding Cultural and Political Responses to Environmental Transformation (AFREXTRACT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1498778.0
EU funding (EUR): 1498778.0
Participants: 1
Project status: SIGNED

Resource extraction industries have propelled environmental transformation across Africa, most notably between 1950 and 2020. The undeniably dramatic effects of mining and oil drilling on landscapes and lifeworlds have elicited radically divergent cultural and political responses, from apparent acquiescence to violent protest and accusations of ecocide. Yet the nature of the relationship between environmental change and human response in African localities remains extremely poorly conceptualised. AFREXTRACT addresses this gap by analysing how various actors in three emblematic sites - the Witwatersrand, the Copperbelt and the Niger Delta - have experienced and responded to environmental change. The first study to investigate this comprehensively and comparatively, AFREXTRACT demonstrates that insights from environmental history, political ecology and environmental humanities are crucial to topical debates about coloniality/decoloniality and the Anthropocene. Our main objectives are: 1) to identify the causal factors informing human response to environmental transformation through three in-depth case studies (gold mining in South Africa; copper mining in Zambia; oil drilling in Nigeria); 2) to analyse how cultural expression (specifically literature and music) has made sense of environmental change; 3) to conceptualise varieties of environmentalism beyond a binary of resistance and resignation. AFREXTRACT will combine archival research with oral history, literary analysis and ethnomusicology to document changing values regarding the environment. A new analytical framework will facilitate engagement with global discussions about extractivism, colonialism/postcolonialism, environmental inequality and climate change. As resource extraction and its toxic legacies are set to continue, a historical understanding of these issues is imperative.

Keywords: environmental history environmental humanities resource extraction political ecology africa
MaaSiveTwin–MAnufacturing as a service And Supply chain predictIVE Twin for critical raw materials (MaaSiveTwin)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Germany,Serbia,Poland,Greece,Cyprus,Switzerland
Call: Achieving resiliency in value networks through modelling and Manufacturing as a Service (Made in Europe Partnership) (RIA) (HORIZON-CL4-2023-TWIN-TRANSITION-01, 2023)
Start date: 2024-04-01
End date: 2028-06-30
Duration (months): 51.0
Total project cost (EUR): 5253290.0
EU funding (EUR): 5253290.0
Participants: 9
Project status: SIGNED

MaaSiveTwin aligns with the vision of creating a competitive and sustainable digital Europe and green value chain by even combining the two aspects! This twin enables Manufacturing as a Service by tracking mining and processing of critical raw materials (CRM) which will be tested by the first Li-refinery in Europe, RockTech and the first large scale LiFePO4 battery manufacturer, ElevenEs. The twin helps to improve efficiency of the supply chain, reduce uncertainty, and support informed decision making, all of which are critical for supporting the transition to a more sustainable economy. MaaSiveTwin will provide real-time data analysis and insights of CRM mining, shipping, processing, and sustainability. Additionally, by predicting scenarios based on disruptive events such as Suez channel blockage, the tool will enable participants to use other suppliers as Manufacturers as a Service in case of Supply Chain disruption to keep machinery in their factories running, increase utilisation and enable fully integrated, resilient value chains from mining of CRM till the end products. MaaSiveTwin extends the analysis of critical materials for e.g Li, Co, Ni that go into batteries, light and heavy rare earth elements that go into magnets for wind turbines and e-motors, Vanadium for redox flow cells, Pt for H2 fuel cells and many more to enable the transition to green energy technologies which are based on CRMs to achieve the Green deal goals, “fit-for-55” and the EU critical raw material act which was proposed in 03/2023. This digital twin will track the path towards our ambiguous EU goals and make European CRM value chains more digital and more resilient.

Keywords: critical raw materials,digital twin,supply chain prediction,manufacturing as a service,maas
Chirality based all-optical logic gates (ChirLog)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Finland,United Kingdom,Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 3
Project status: CLOSED

With the ever-growing demand for carrying and processing data in a fast and efficient way, optical computing and processing methods have become a promising candidate for the next-generation computing and processing applications, due to many advantages, such as high-speed and parallel data processing, compared to their electronic counterparts. In this project, I plan to construct the world first chirality-based all-optical logic gates. The initial plan is to significantly extend the preliminary results to many other nonlinear optical processes in monolayer two-dimensional layered materials with the aim to construct various chirality logic gates such as XNOR, XOR, NOR, AND, NAND, OR, Buffer, and NOT gates. I will also construct ultrafast (<10 fs) multiple-logic functions simultaneously with phase-matching-free nonlinear optics. Further, I will combine the valley properties of two-dimensional materials to demonstrate electrically configurable chirality logic gates. The chirality logic gates built in this project will work fundamentally different from the previously demonstrated optical gates, which will offer numerous advantages (e.g., atomically thin footprint, multiple processing, parallel operation, and ultrafast processing speed across a wide range of wavelengths).

Keywords: computing logic gate chirality two dimensional layered material