Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ISOS-Implantable Ecosystems of Genetically Modified Bacteria for the Personalized Treatment of Patients with Chronic Diseases (ISOS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Germany,Italy,United Kingdom
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2023-12-01
End date: 2026-11-30
Duration (months): 36.0
Total project cost (EUR): 2433300.0
EU funding (EUR): 2433300.0
Participants: 7
Project status: SIGNED

In ISOS we propose to develop the first biomedical product for the in-situ fabrication and auto-renewed delivery of therapeutic compounds employing complex ecosystems of probiotic genetically engineered bacteria (GEB) integrated in a biomaterial-based bioreactor. ISOS is designed to treat chronic diseases requiring lengthy treatments. The encapsulated GEB populations produce the therapeutic molecules "on demand", stimulated by the signals of the pathological environment within the patient, i.e., inflammation and/or reactive oxygen species. Bacteria populations interact among them to maintain a dynamic equilibrium of the GEB species and to guarantee the survival of the drug-producing GEB as long as the disease persists. The GEB ecosystem is designed in such a way that bacteria cannot survive outside of the encapsulating biomaterial, to meet future biosafety and regulatory requirements. The design and the configuration of the GEB ecosystem will be personalized for each patient, and it will be done using in-silico tools and synthetic biology. As a Proof-of-Concept, we propose to engineer an implantable GEB-based bioreactor for the therapy of the wet form of age-related macular degeneration (wAMD), which is caused by an abnormal production of Vascular Endothelial Growth factor (VEGF). This Proof-of-Concept will demonstrate the ability of ISOS to replace the repeated intraocular injections of Anti-VEGF molecules (current treatment) with a single ISOS bioreactor that will enhance the therapeutic response and minimize side effects due the molecular crosstalk between ISOS and the pathological environment. ISOS will establish the principles of a new generation of therapeutic products that will use recombinant probiotic bacteria strains libraries for personalized treatments with rigorous control of local drug production and efficient delivery based of dynamic variation of pathological signals.

Keywords: bacteria,protein,peptide,vascular endothelial growth factor vegf,anti vegf,
Unravelling specificity of epi-metabolic regulation in mouse development (ChroMeta)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

When environment of the embryo changes or when development progresses metabolic reactions are rapidly affected. These alterations to chemical reactions are coupled to epigenetic memory. However, without mechanistic data on how this coupling occurs it is difficult to understand how normal embryogenesis can proceed. This project will elucidate how metabolic changes result in specific epigenetic outcomes and address the function of such regulation. As a model we will use mouse implantation, a process tightly linked to dramatic alterations to chromatin and transcription. We found that this is also associated with extensive metabolic rewiring and that disrupting metabolic flows results in both lineage-specific and mark-specific changes to chromatin. While multiple studies uncovered that metabolism fuels chromatin modifiers with co-factors, the fundamental biological question of how specificity is achieved remains unanswered. Here we will address this challenge by directly testing the three most likely hypotheses: 1) that metabolic reactions shuttle into the nucleus where they specifically fuel chromatin changes; 2) that chromatin-bound metabolic enzymes regulate gene expression and 3) that only specific chromatin modifiers are sensitive to metabolic changes. To address these questions, we will go beyond description as we supplement multi-omic approaches with mechanistic experiments both in vitro and in vivo. Firstly, will use perturbations of nuclear metabolic enzymes and their chromatin binding. Secondly, we will implement protein engineering to render chromatin modifiers resistant to the availability of their co-factors. By uncoupling epi-metabolic regulation, we seek not only to uncover its importance for controlling chromatin states but also the implantation developmental program. This project will form a framework of how future studies can mechanistically unravel intertwined regulatory processes and assess the role of environment and nutrition in early pregnancy.

Keywords: heterochromatin,polycomb,implantation,blastocyst,dna methylation,histone modification
Deal Engine, with finance, investment and technical expertise for the Circular Cities and Regions Initiative (DEFINITE-CCRI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Coordination and support actions
Countries involved: Germany,Netherlands,Ireland,Belgium,Greece
Call: Circular Cities and Regions Initiative’s project development assistance (CCRI-PDA) (HORIZON-CL6-2022-CIRCBIO-01, 2022)
Start date: 2022-11-01
End date: 2025-06-30
Duration (months): 32.0
Total project cost (EUR): 1978837.5
EU funding (EUR): 1978837.5
Participants: 5
Project status: SIGNED

Effective investment and financing opportunities for circular economy projects in Europe are still few and far in between. Investors need to gain trust in circular economy projects. Projects need to become less risky and bankable, based on new and re-designed finance solutions and business models. Transaction costs need to be decreased and the private finance community needs to be engaged to address legal, administrative and market challenges. The DEFINITE-CCRI project establishes a deal engine, providing technical, financial and circular economy expertise through local project development assistance in an unprecedented and streamlined process to cities, regions and project developers. The deal engine will be built with investors and finance partners and the goal to launch investments in four circular economy projects of up to EUR 20 million investment volume per project, amounting to a total portfolio volume of up to EUR 80 million. The DEFINITE-CCRI will demonstrate the bankability of high-impact circularity projects and increases maturity and investor trust in circular economy innovation. It closes the gap between project developers in cities and regions on one side, and investors and finance partners on the other. The DEFINITE-CCRI project co-creates and proves an end-to-end PDA process, aggregating risk-mitigation, EU Taxonomy compliance, circularity criteria and technical and financial engineering in a single project development service for the CCRI’s service portfolio. Partners commit to operate the deal-engine sustainably beyond the project lifetime. This will inject the financial, technical and managerial know-how into urban circular transitions and ultimately contribute to lower virgin non-renewable material use, lower GHG emissions and more just and inclusive circular employment in line with the European Green Deal, the Circular Economy Action Plan and the Bioeconomy Strategy.

Keywords: finance,investment,circularity,circular economy,cities,regions,project development assistance,bioeconomy,eu taxonomy,risk management,sustainable finance,closed loop,lifecycle
Decadal to multi-deCadal Global Predictions of Compound Events (DeCaGloPreCEs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: CLOSED

Compound events (CEs) can pose significant threats to societies, economies and ecosystems around the world, especially when amplified by anthropogenic climate change (ACC). There is therefore a strong need for skillful, reliable and actionable predictions of how CEs are expected to change in the next decades, to support governments and stakeholders in implementing robust adaptation strategies. In this project, we will develop a method to improve near-term projections of CEs at the global scale, taking into account their response to both climate variability and long-term warming, and develop a sound physical mechanism understanding of their meteorological drivers. First, we will constrain climate projections with decadal climate predictions, from the Coupled Model Intercomparison Project Phase 6, with a novel method to reduce the uncertainty and increase accuracy of ACC predictions up to 30 years. Then, we will apply an innovative method grounded in dynamical systems theory for quantifying CEs and link them to physical extremes in the global regions where the prediction of events shows high skill. We will specifically focus on temperature-(low) precipitation as related to summer heatwaves and precipitation-wind as a proxy for storms. The analysis will elucidate what drives CEs in the context of global warming and climate variability, to what extent they can be predicted on decadal to multi-decadal time scales, and how their frequency, intensity and persistence is expected to change in the future. We will furthermore explore the atmospheric drivers of the CEs, to elucidate specific physical mechanisms at the origin of the events. The outcomes of the project will be significant for the scientific community, since they will improve the understanding of how CEs respond to ACC and climate variability, and relevant for governments and stakeholders aiming to reduce losses from high-impact weather events, benefiting societies and economies around the world.

Keywords: climate,meteorology,climate extremes,compound events,climate dynamics,climate predictions,climate models,heatwaves,storms,modes of climate variability,predictability
HORIZER (HORIZER)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Germany
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-03-31
Duration (months): 9.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

In Women TechEU, HORIZER aims, over the next 9 months, to continue its personal impact pathway journey of transforming the vehicle and energy market of Europe by focusing on testing and validation the business model, market research and engagement, and full utilization of the EIC growth-oriented services and mentorship.
Fluorinated Lipid Nanoparticles for Gene Delivery and Diagnostics (FluoNeeD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-06-01
End date: 2026-08-31
Duration (months): 27.0
Total project cost (EUR): 212163.84
EU funding (EUR): 212163.84
Participants: 3
Project status: CLOSED

The formulation of drug nanocarriers has attracted increasing attention over the last decades. In particular, the possibility to combine therapeutic and imaging functionalities in a single nanoplatform (theranostic) has been widely explored to advance therapeutic approaches and promote the transition from conventional medicine to personalized medicine. Drug nanocarriers, holding the potential to produce a revolution in medicine, are lipid nanoparticles (LNPs) for gene delivery. They have proven versatility and efficacy even though today it is still not possible to predict and control their cellular uptake and targeted delivery. One of the main unmet challenges of LNP formulations is increasing their cellular uptake and gene release into the cytosol. Currently, it is possible to follow the fate of LNPs after administration only with the addition of labels (e.g., fluorophore) or specific ribonucleic acid (RNA) sequence encoding for fluorescent protein. This results in the lack of possibility to follow the fate of LNPs once administered in vivo with a non-invasive imaging technique. Theranostic strategies to deliver RNA and simultaneous imaging of target organs is an important unmet goal. Recently, it has been demonstrated that fluorination of components in gene delivery vehicles strongly improved their cellular uptake and, most importantly, their gene endosomal escape. The fluorination strategies investigated so far use either -CF3 groups or long linear perfluoroalkyl chains, but a tailored design of the fluorinated group could also endow the nanocarrier with excellent imaging functions. In this context, FluoNeeD strategy is to tailor fluorination of LNPs in order to: (i) improve their therapeutic efficacy by enhancing LNP cellular uptake and promoting gene endosomal escape; (ii) render LNPs trackable in vivo by 19F-MRI and in vitro/ex vivo by Raman microscopy.

Keywords: lipid nanoparticles,fluorine chemistry,gene delivery,19f mri
Resolving the Multiscale, Multiphase Universe (ReMMU)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-07-01
End date: 2030-06-30
Duration (months): 60.0
Total project cost (EUR): 1492750.0
EU funding (EUR): 1492750.0
Participants: 1
Project status: SIGNED

Galaxies grow through the reciprocal cycling of gas between disks and their massive surrounding halos. Despite major strides in observations and simulations, the physics regulating this galactic ecosystem remains unclear, primarily due to the multiphase, multiscale nature of circumgalactic gas. All current cosmological simulations fail to capture the multiphase structure of galactic halos and exhibit a lack of convergence in even the first order gas properties such as the amount of cold gas found. This strongly limits their applicability in the circumgalactic medium to interpret existing observations as well as their predictive power. ReMMU will breach this barrier by implementing an innovative multi-fluid subgrid model to track unresolved gas phases both in hydrodynamical and radiative transfer simulations. The objectives of ReMMU are to (1) run the first cosmological simulation with converged gas properties and (2) perform a robust comparison with absorption as well as emission line data of galactic ecosystems. This work will shed light on the drivers of galactic growth and feedback mechanisms, the key challenge to understand the formation and evolution of galaxies. Only recent advances in fundamental hydrodynamical theory have constrained the parameter space sufficiently and, thus, opened the pathway for subgrid models of unresolved gas. Simultaneously, a rapidly growing body of observational surveys started to revolutionize the available data on galactic ecosystems. Hence, ReMMU is particularly timely combining these advances: it will exploit the theoretical progress in a full cosmological context and establish firm predictions for comparison with observations across cosmic time, ultimately breaking the current impasse. The PI has made significant contributions in the theory of small scale hydrodynamical as well as radiative transfer problems and is, therefore, uniquely suited to establish a world-leading team to carry out ReMMU.

Keywords: circumgalactic medium,galactic ecosystem,multiphase gas,radiative transfer,computational astrophysics,galactic feedback and fueling,galactic winds,cosmological simulations,galaxy formation,galaxy evolution
Advancing QUAsiperiodic metal-organic FRAMEworks for atmospheric water harvesting (AQUAFRAME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2028-05-31
Duration (months): 36.0
Total project cost (EUR): 420751.08
EU funding (EUR): 420751.08
Participants: 3
Project status: SIGNED

The world stands on the brink of a major water crisis. The distributed capture of water from the atmosphere through sustainable materials is an innovative approach that holds great promise for the mitigation of water insecurity. Metal-organic frameworks (MOFs), with their unprecedented porosity and chemical tunability, have recently proved to be ideal candidates for real-world atmospheric water harvesting. However, current MOF water harvesters have serious drawbacks, including high energy consumption and low water productivity in non-temperate climates. The AQUAFRAME project aims to develop and thoroughly characterize MOFs with random and correlated disorder (“quasiperiodic MOFs”) to improve the efficiency of the atmospheric water harvesting process. The objectives of the interdisciplinary proposed research are to merge quasiperiodic MOF (a) synthesis, (b) synchrotron X-ray characterization and (c) computational modelling to gain molecular-level insights into the ways disorder influences MOF water uptake, paving the way for the design of next-generation water harvester systems that break current performance records. The project will have scientific, economic and social impact as it is designed to transform the established view of water harvesting MOFs as perfectly ordered materials, and to provide a novel solution to the global challenges related to water scarcity. It will be supervised by eminent scientists including Prof. Omar Yaghi of the University of California at Berkeley, the inventor of MOFs and foremost developer of MOF water harvesting systems. It will incisively contribute to the researcher’s career development by allowing him to acquire interdisciplinary research and transferable skills at Sapienza University of Rome, UC Berkeley, and during a secondment at Columbia University. The project will produce research methods in a cutting-edge field, articles intended to deliver scientific breakthroughs, and dissemination and outreach to key target audiences.

Keywords: mof mofs metal organic frameworks reticular chemistry atmospheric water harvesting computational chemistry x ray spectroscopy x ray absorption spectroscopy xas pair distribution function pdf
Predicting protein evolutionary trajectories toward resistance against antiretroviral treatments (PRERES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Drug resistant mutations can appear when the selective pressure given by a pharmacological treatment causes the evolution of pathogen proteins towards variants that become unaffected by the drug. Currently, to select therapies against pathogens, genotypic resistance analyses and tables of resistance mutations are employed to decide the best treatment for the patients. However, these screenings ignore evolutionary changes that can appear as pathogens adapt, potentially leading to drug resistance. To address this limitation, the prediction of which variants are more probable to occur in the pathogen population can be useful in selecting "a priori" therapies active against those variants before their potential expansion toward reservoirs more inaccessible to drugs. In this proposed work, I will apply molecular evolution and computational structural biology techniques to evaluate the evolutionary trajectories of HIV-1 drug targets proteins that lead to resistance against common antiretroviral treatments. I will calculate protein fitness landscapes based on protein folding stability and activity, also considering binding to inhibitors. Next, I will use evolutionary information from protein fitness landscapes to improve substitution models of evolution. The evolutionary trajectories predicted by combining substitution models and fitness landscapes will be validated through comparisons with real data from monitored HIV-1 populations evolved "in vitro" and "in vivo". Finally, I will focus on calculating the probability of evolutionary trajectories toward resistance variants. This research has the potential to improve the selection of therapies for pathogens by providing predictive tools that consider the evolutionary dynamics of these microorganisms. Furthermore, the results of the project have the potential to be a breakthrough in the field of molecular evolution as this methodology could also be applied to predict the evolution of other pathogens.

Keywords: protein evolution,molecular evolution,protein modelling,fitness landscape,computational biochemistry