Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The hypothalamic control of behavioral and physiological adaptations to stress (HypoAdapt)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-04-01
End date: 2031-03-31
Duration (months): 60.0
Total project cost (EUR): 1498418.0
EU funding (EUR): 1498418.0
Participants: 1
Project status: SIGNED

When faced with threats to their survival, animals execute flexible behavioral adaptations specific to each threat, such as escaping a predator. These behaviors are accompanied by brain-driven physiological changes, including elevated heart rate, blood pressure and respiration, which are critical for meeting the increased energy demands during stress. While behavioral responses to threats have been extensively studied, the neural mechanisms that coordinate the accompanying physiological changes remain poorly understood. Additionally, it remains unclear how the brain orchestrates behavioral and physiological adaptations in tandem. HypoAdapt aims to bridge this knowledge gap by investigating the organization and function of the hypothalamus — a critical brain region responsible for both behavioral and physiological responses to homeostatic challenges. Specifically, we will focus on the dorsomedial hypothalamus (DMH) through the following aims. Aim 1: Decipher the anatomical and functional organization of the DMH circuitry that controls responses to distinct stressors. Aim 2: Define how inhibitory inputs to the DMH control the dynamic execution of behavioral and physiological responses with precise timing and vigor. Aim 3: Discover the role of neuropeptide inputs to the DMH in regulating stress state by modulating the underlying neural circuits. By employing cellular resolution neural imaging, machine-learning-based behavioral tracking, monitoring of physiology and neural circuit mapping and manipulations, HypoAdapt will be the first study to offer a holistic view of the neural circuit mechanisms underlying survival adaptations to threats. These findings will illuminate general principles underlying brain-controlled processes that require both rapid and long lasting regulation. Additionally, this research has the potential to inform about mechanisms underlying dysregulation of these behavioral and physiological adaptions in stress and anxiety disorders.

Keywords: physiology,behavior,calcium imaging,neuroanatomy,neuromodulation,crispr cas9,optogenetics,fiber photometry
Advanced Intelligent stimulation device: HAND movement restoration (AI-HAND)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,Germany,Luxembourg
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-08-01
End date: 2027-01-31
Duration (months): 42.0
Total project cost (EUR): 2999834.25
EU funding (EUR): 2999834.25
Participants: 6
Project status: SIGNED

Very advanced stimulation paradigms applied to peripheral nervous system (PNS) have been studied for years even decades among which the 3D current distribution through multi-contact epineural electrodes. Non rectangular stimulus waveforms are also of strong interest to provide more efficient or fibre type selective stimulation. However none were implemented in an Active Implanted Medical Device and thus almost none validated through clinical trials. One of the reasons is the high complexity of the needed analogue front end and its safe control by a microcontroller or a digital system. AI-HAND project aims at developing a breakthrough, ASIC based technology, together with a specific self adapting epineural multi contact electrode to provide such an AIMD. The demonstration of the clinical relevance of such an approach will be achieved through a first-in-man proof of concept aiming at the restoration of hand movements in persons with complete quadriplegia. It means that a full innovative device should be developed and validated in animals, but the real added value will be supported by the clinical trial; indeed, no animal model exists while the clinical needs is clearly stated by clinicians and patients. Thus this project will innovate concerning both the technology and the therapeutic approach with a minimally invasive concept. Indeed, spatial selectivity allows to stimulate nerves selectively targeting muscles through 3D currents shaping instead of implanting one electrode per muscle. The technology clearly addresses generic issues so that the paradigms and the innovative technology can be further used to stimulate the central nervous system (spinal cord and brain) and, on a long term basis, may drastically open new therapeutics for medical needs that are still unmet.

Keywords: neuroprosthesis,neural tissue stimulation,selective spatial stimulation,aimd,multi contact cuff electrode
Tuning Oxide Pyrochlores: Optimizing Lattices for Observable GeneratIon of Quantum magnetoelectric phenomena (TOPOLOGIQ)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1499982.0
EU funding (EUR): 1499982.0
Participants: 1
Project status: SIGNED

Topological magnons offer immense promise for the development of dissipation-less spintronic devices. However, the ability to control these spin excitations through electric fields remains a significant challenge due to the difficulty in stabilising systems that exhibit both topological and magnetoelectric properties within a single framework. TOPOLOGIQ aims to address this by creating a novel epitaxial platform based on pyrochlore oxides (A2B2O₇), with the final goal of combining topological and magnetoelectric properties in an oxide material for the first time. Bulk pyrochlore oxides host a rich variety of quantum phenomena due to the interplay between electron, spin, and orbital degrees of freedom in a geometrically-frustrated lattice. Recent advancements in epitaxial growth and related nanotechnology provide the tools to precisely control factors like strain, dimensionality, oxygen stoichiometry and interface proximity, offering a unique opportunity to manipulate these complex interactions in thin-film form. TOPOLOGIQ’s strategy encompasses four core objectives: 1) Growing high-quality magnetically-ordered pyrochlore heterostructures, 2) Inducing structural transitions by manipulating strain, confinement, periodicity, and oxygen non-stoichiometry, 3) Characterising the emerging topological and symmetry properties using resonant spectroscopic probes, and 4) Modulating these properties via external magnetic and electric fields. This ambitious approach extends the use of cutting-edge nanotechnology beyond the perovskite oxides (ABO3) commonly studied in this context, unlocking the potential of pyrochlore oxides as novel quantum materials. By achieving atomic-scale control over magnetoelectric coupling and magnon topology, TOPOLOGIQ will establish a new paradigm in material science, with broad implications for energy-efficient devices and quantum technologies.

Keywords: epitaxy,complex oxides,pyrochlores,topological magnons,magnetoelectrics,oxygen ion conductors
PRESSurized HYdrogen prOdUced by high temperature Steam electrolysis (PressHyous)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: France,Estonia,Netherlands,Finland,Switzerland
Call: Development and validation of pressurised high temperature steam electrolysis stacks (Solid Oxide Electrolysis) (HORIZON-JTI-CLEANH2-2022-1, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 2499426.0
EU funding (EUR): 2499426.0
Participants: 12
Project status: SIGNED

The production and use of clean H2 is a key lever for the decarbonation of industries, as a fuel for transportation and as a storage vector for renewable electricity at large scale. The RePowerEU plan, for saving energy, producing clean energy, and diversifying energy supplies sets out a strategy to double the previous EU renewable H2 target (10 million tons/y of domestic production +10 million tons/y of H2 imports). Meeting these targets requires the EU to significantly upscale its manufacturing capacities for innovative equipment such as electrolysers. However, using H2 requires given levels of pressure depending on applications. Thus to pave the way to the delivery of down to zero emissions of pressurised H2 at reduced cost (around 3 €/kg by 2030), PressHyous will validate the operation of a 20 kWe pressurised lab-scale device (eq. 13.5 kg H2/d) composing of a solid oxide electrolyser (SOEL) stack placed in a pressurised vessel, up to 30 bar at 1 A/cm2 and 1.3V during 4000h. PressHyous will also investigate a promising pressurised stack concept (without pressure vessel) relieving the cost of Balance of Plant. This will be tested up to 10 bar at short stack scale, at a similar current density to the stack operated in a pressurised vessel. These two stacks will integrate optimised components such as cell and sealing. PressHyous will in parallel deliver model-based insights for H2 production under pressure for up to 5 identified use cases, on expectable performances of both stack concepts (with or without pressurised vessel) towards large scale developments up to 100s MWe, in strong link with techno-economic and life-cycle analysis. PressHyous consortium gathers a large portfolio of skills from modelling to system manufacturing, and a wide range of partners (RTOs and industrials) all along the value chain. The scientific and technological activities are all intended to strive towards the overall design and validation of future MWe large scale pressurised SOEL.

Keywords: soel pressurised hydrogen electrolysis stack soc tea lca
Simple and cost-effective cancer diagnosis in liquid biopsy through native tRNA sequencing (tRNADiagnostics)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-01-01
End date: 2026-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Transfer RNAs (tRNAs) are abundant, heavily-modified small non-coding RNAs that play a pivotal role in decoding genetic information, determining which transcripts are highly and poorly translated at a given moment. Dysregulation of tRNA abundances and tRNA modifications is a well-known feature in cancer cells, leading to enhanced translation of specific oncogenic proteins. Despite the well-established association between tRNA dysregulation and cancer progression and malignancy, tRNA abundances and their modifications are still not being used as diagnostic or prognostic markers for cancer detection or progression, mainly due to the lack of a simple, unbiased and cost-effective method to quantify tRNA abundances and their modifications. Our laboratory has recently established Nano-tRNAseq, a pioneering method that can accurately quantify both tRNA abundances and tRNA modifications using native tRNA nanopore sequencing, for a fraction of the cost of next-generation sequencing-based approaches. By employing a proprietary Nano-tRNAseq nanopore library preparation protocol coupled with deep learning algorithms that will rapidly classify the nanopore current signals, here we aim to establish a method that exploits tRNAs as novel biomarkers through the use of third generation sequencing technologies. We have initial evidence of how our approach can separate cancer from non-cancer samples and possibly be used to identify the tissue of origin. In this project, we will fully validate our technological platform for the differential analysis of low-input RNA amounts in liquid biopsy samples. We will initially apply our method in the cancer arena, expandable to many other indications, following the advice of key stakeholders contacted so far, with the goal of laying the basis for the transfer of our technology to the marketplace, including through the creation of a new start-up company.
CoFutures Literacy (COFUTURESLITERACY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Norway
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-08-01
End date: 2025-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

People around the world imagine futures differently. These imaginations of the future are most clearly found in the fictions they produce (Future Fictions or Speculative Fiction; SF). SF acts as a repository of ideas related to societal change, technological change, climate change, and other kinds of change. How do we take these different imaginations, and use them to drive societal innovations? How do we work with the complexity of visions around the world, not merely in its richer parts but in its poorer, or developing parts, to think new kinds of futures: economic, cultural, political? And how do we scale and translate these visions for use in policy and policy-adjacent contexts, how can they inspire new social and technological developments? While the need for these fictions to drive innovation is by now well-known at research and policy level, the core problem is that there have been no methodologies, no tools, and no frameworks that acknowledge the deep complexity of global, creative imaginaries of the future and feed them directly into new ways of thinking about societal challenges. In the PoC-CoFutures Literacy, we will take people’s imaginations of the future, especially as found in SF, and systematize the methods used by creative professionals globally to imagine futures. These creative methods will be combined with methods used in innovations, scenario and policy work to understand, anticipate and generate futures. Together, this will form the knowledge solution we term CoFutures Literacy. The PoC will develop this knowledge solution by taking some of the central ideas from diverse imaginations of the future worldwide from SF research done by the ERC-STG CoFUTURES (2020-2024), combine these with existing models of futures and innovation research, and crystallize these functions into three modules of the knowledge solution: a) a comparative methodological toolkit, b) a research and design handbook, and, c) an open media and lecture library.
Empowering citizens in collaborative environmental compliance assurance via MOnitoring, REporting and action (MoRe4nature)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: Netherlands,Spain,Denmark,Portugal,Ireland,Norway,United Kingdom,Belgium,Poland,Ukraine,Germany
Call: Empowering citizens to monitor, report and act in partnership with relevant public authorities to protect their environment in the context of environmental compliance assurance (HORIZON-CL6-2023-GOVERNANCE-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 7229083.75
EU funding (EUR): 7229083.75
Participants: 21
Project status: SIGNED

MoRe4nature aims to trigger transformative change in conservation efforts regarding zero pollution, biodiversity protection and deforestation prevention by including citizens and communities as key actors in collaborative environmental compliance assurance (ECA). A key element in reversing the trend in environmental degradation is a change in environmental compliance assurance interventions. Citizen Science Initiatives (CSIs) present innovative ways of joint data and knowledge production and of empowering citizens in sustainable natural resource management. However, barriers to the uptake of Citizen Generated Data (CGD) and citizen actions in ECA have not been effectively tackled. MoRe4nature will use a socio-technical approach to address these challenges and deepen the role of citizens and communities in ECA by i) strengthening the capacity of existing CSIs to provide relevant and valid data and understanding the importance of ECA, ii) fostering and supporting collaboration and partnerships among citizen science initiatives and authorities to cover data gaps and shape policy monitoring frameworks, iii) developing and testing tools to validate data obtained from CSIs, thus contributing to the integration of such data sources in environmental governance and in European Open Science Cloud, iv) making CGD available as a node in the Green Deal Data Space and v) channeling the urgency for concrete and immediate action of many citizens and communities by creating synergies between citizen science initiatives and LivingLabs for EU Missions, partnerships and other initiatives such as Fab Labs which share the values of sustainability transitions and which can help co-design actions as part of green and digital transformations. MoRe4nature will ensure uptake and impact beyond the project duration by engaging 162 existing CSIs and 98 authorities and national agencies in 40 cases in Europe, Latin America, Asia and Africa as well as selected LivingLabs and Fab Labs in Europe.

Keywords: citizen science,environmental compliance assurance,monitor,co design,compliance promotion,enforcement,geospatial,indicator,data,change process,transition,governance
A PRivacy-prOTecting Environment for Child Transplants health-related and genomic data integration in the European Reference Network (PROTECT-CHILD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Greece,Netherlands,Serbia,Germany,Belgium,Switzerland,United States
Call: Better integration and use of health-related real-world and research data, including genomics, for improved clinical outcomes (HORIZON-HLTH-2023-TOOL-05, 2023)
Start date: 2024-06-01
End date: 2028-11-30
Duration (months): 54.0
Total project cost (EUR): 8091327.5
EU funding (EUR): 8091327.5
Participants: 19
Project status: SIGNED

PROTECT-CHILD is a project that aims to improve the outcomes of rare pediatric transplant patients by integrating multiple sources of high-throughput data from registries, hospital-based and public repositories, complying with ongoing initiatives such as the European Open Science Cloud (EOSC) and the European Health Data Space (EHDS). The project focuses on the co-design of a secure and privacy-preserving infrastructure, harmonization of data standards, and creation of a public/private infrastructure for assembling large datasets to improve clinical outcomes. The project involves top-level expertise from a consortium of technology specialists, data standardization experts, and High-Performance Computing (HPC) centers, as well as clinical experts, legal experts, patients’ representatives, and policy makers. The project is aligned with EHDS and General Data Protection Regulation (GDPR) principles and aims to empower secure and compliant processing, analysis, and sharing of sensitive personal data, including genomics, while preserving data privacy and security.

Keywords: pediatric transplantation,data integration,data governance,data privacy,metadata,multi platform,multi scale,multi source,machine learning,predictive modeling,clinical decision making
Revisiting Rainfall Extremes with Ensembles of Convective Objects aNd their Continuum of Interactions with the Large-scale Environment (RECONCILE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 1322000.0
EU funding (EUR): 1322000.0
Participants: 1
Project status: SIGNED

As climate changes, weather becomes more severe. This has been of long-standing concern, and difficulties arise in connecting the two different ranges of scales involved. Hail, rainshowers and strong winds result from the local dynamics of cloud updrafts, while the general circulation determines the relative occurrence of convective regimes to maintain energy balance. Historically, limitations in computing power mostly led to separate analyses of cloud dynamics and the large-scale circulation. The mesoscales, in-between, host a rich ecosystem of weather features, organized in a diversity of shapes and morphologies but overly simplified in traditional climate models. This scale separation leads to large uncertainties in the projection of future extremes: the dynamic adjustment of weather systems to the large-scale flow is unconstrained, and small-scale perturbations may feed back onto the global climate state. RECONCILE revisits how the multi-scale character of extreme precipitation emerges from the interaction between storms and the large-scale circulation. It introduces a novel approach by focusing on the dynamics of storm populations rather than individual storm objects. This paradigm of populations is borrowed from ecology and scarcely used in climate physics. It allows to overcome strong biases present in operational climate models, by allowing for a diversity in the represented cloud structures and an explicit two-way interaction across the continuum of scales. The current emergence of global storm-resolving models is an unprecendented opportunity to investigate this dynamic coherence across multiple scales of motion. RECONCILE proposes a way forward, at the intersection of two WCRP's grand challenges: Weather and Climate Extremes, and Clouds, Circulation and Climate Sensitivity, with strong implications for climate model evaluation.

Keywords: precipitation extremes,convection,mesoscale convective systems,organization,scale interaction,radiative convective equilibrium