Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Magnetic Reconnection Hollow Cathode Thruster (MaRe-HCT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2025-06-30
Duration (months): 28.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 2
Project status: CLOSED

The goal of this project is the realization of a novel space electric thruster concept based on magnetic reconnection as acceleration mechanism and on a hollow cathode as plasma source. Electric propulsion (EP) is fundamental to enable the foreseen human and robotic missions to the Moon, Mars, and beyond, which require adequate propulsion system to deliver the needed delta-V. The current strategy to develop such high specific impulse and high thrust EP system entails the scaling up process of well-known EP systems such as ion and Hall thrusters. However, this strategy depends mostly on the thruster footprint, which will impact the spacecraft dimensions and weight. We believe that an effort has to be made to conceive a novel propulsion concept, overcoming the present limits. Magnetic reconnection is a topological rearrangement of interacting field lines that produces a configuration of lower magnetic energy, an outflowing plasma, and the acceleration and heating of charged particles. Magnetic reconnection is preponderant in solar flares, coronal jets, Earth’s and planetary magnetosphere. Potentially, it can be employed as main acceleration mechanism of a novel thruster concept. Within MaRe-HCT (Magnetic Reconnection Hollow Cathode Thruster), we propose a thruster concept based on magnetic reconnection to accelerate the plasma jet and on well-known flight-proven hollow cathodes as plasma source, to obtain a high specific impulse and high thrust EP system. It can potentially guarantee up to 50000s of specific impulse, at least one order of magnitude higher than the values achievable by state-of-art propulsion systems. MaRe-HCT will give the researcher the chance to grow as an independent and mature researcher while expanding her expertise in electric propulsion and plasma physics. At the same time, it will provide the beneficiary the opportunity to broaden its research activities to novel EP concepts and plasma physics open topics such as magnetic reconnection.

Keywords: space propulsion,electric propulsion,plasma physics,plasma diagnostics
Preventing obesity through Biologically and bEhaviorally Tailored inTERventions for you - BETTER4U (BETTER4U)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Greece,Portugal,Denmark,Belgium,Sweden,Austria,Finland,Spain,Poland,Estonia,Germany,Netherlands,Ireland,Israel,Italy,Romania,Switzerland,Australia,United Kingdom,Cyprus,France
Call: Prevention of obesity throughout the life course (HORIZON-HLTH-2022-STAYHLTH-01-two-stage, 2022)
Start date: 2023-11-01
End date: 2027-10-31
Duration (months): 48.0
Total project cost (EUR): 9495241.5
EU funding (EUR): 9488616.0
Participants: 30
Project status: SIGNED

BETTER4U aims at the identification and personalized management of all weight gain determinants to battle the increasingly rising numbers of overweight/obesity, via homogenous, globally adaptable and practically assessed public health initiatives and key interventions. Building on previous key projects and biobanks, the project will focus on the hitherto neglected impact of the polygenic background of weight gain on the effectiveness of lifestyle interventions for weight management in people with overweight/obesity. BETTER4U aims to probe into the global obesity challenge, study the problem and offer solutions in a tangible realistic way with the assistance of modern AI technologies and the contribution of experts around the world. BETTER4U will be realized through the following objectives: 1. To comprehensively understand and decipher genetics, metabolomics, microbiota, socio-economic, geographical, cultural and lifestyle features linked to weight gain throughout the life course, via meta-analyses (BETTER4U data from >50 studies, >1 million individuals) and extensive literature meta-review. 2.To develop the BETTER4U intervention methodology for weight gain prevention, based on a causal AI model of obesity determinants and a pilot study in 7 European countries. 3.To deploy technology-assisted, real-time monitoring tools to measure detailed behavioral indicators and their relation to the environmental context. 4.To evaluate the efficacy of the novel BETTER4U intervention methodology in a controlled, randomized clinical trial, based on individually-tailored recommendations for lifestyle change. 5.To maximize transferability and applicability of the BETTER4U intervention methodology by identifying implementation barriers and facilitators, as well as to evaluate implementation outcomes in both participants and stakeholders. 6. To develop and disseminate the BETTER4Uobesity prevention intervention methodology guidelines using a people-centred, sustainable care approach.

Keywords: weight gain,prevention of weight gain,understanding of biological pathways,weight gain biology,causal models,lifestyle intervention,integrated methodology,personalized guidelines
Partial reprogramming for hematopoietic system rejuvenation: Impact on systemic hallmarks of aging and health span (REJUVIMMUNE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 252180.0
EU funding (EUR): 252180.0
Participants: 1
Project status: SIGNED

Aging is a complex process, encompassing the decline numerous cell types and organs. In this regard, recent progress suggests that the hematopoietic system is particularly influential; as we age, hematopoietic stem cells (HSCs) preferentially differentiate toward the myeloid lineage, thus losing their ability to regenerate fully functional blood tissue. Furthermore, a decline in the effector capacity of immune cells accounts for insufficient immunosurveillance of senescent cells, leading to their accumulation throughout the body. From a therapeutic perspective, the hematopoietic system is particularly malleable to rejuvenating interventions. In recent years, strategies of epigenetic reprogramming achieved through the transient expression of the Yamanaka factors Oct4-Sox2-Klf4 (OSK) and the facultative expression of c-Myc -referred to as partial reprogramming- has progressively garnered attention for its potential application in regenerative medicine. Their capacity to transiently push fate-committed cells back to their developmental program and to remove epigenetic marks of damage enhances the capacity of tissues to regenerate after injury in several preclinical models. However, it is poorly understood whether single-organ partial reprogramming affects other tissues and health span, without risks for secondary transformation, undermining the translational potential for humans. Across the REJUVIMMUNE project, I leverage on these limitations to develop unique tools –mRNA therapeutics and partial reprogramming mimicking cocktails (PRMCs)– for targeting partial reprogramming on HSCs (Objective 1) and elucidate cell intrinsic and extrinsic effects of OSK-rejuvenation on blood cells -including immune cells- and systemic aging, respectively (Objective 2). In summary, the strategies proposed in this action hold great potential to counteract hematopoietic senescence and mitigating age-associated decline in organismal function, enhancing health span and organismal resilience.

Keywords: aging,hematopoietic system,partial reprogramming,rejuvenation,tissue regeneration,longevity,immune system
Supramolecular Integration of Artificial Molecular Motors in Active Systems : Morphing, Adaptation, Propulsion (SPRING)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2499986.0
EU funding (EUR): 2499986.0
Participants: 3
Project status: SIGNED

Biomolecular motors are fundamental elements in the emergence of dynamic, self-sustaining, and evolving properties that characterize living systems. When fuelled by an external source of energy, they can perform and convert mechanical work into key functions such as catalysis, regulation, transport, actuation, and locomotion. This transduction of energy happens between hierarchical levels of self-organization, which maintain living systems out of thermodynamic equilibrium and link the unidirectional motion produced by the motors with various emerging functions in a remarkably efficient way. Therefore, one could expect that the implementation of artificial molecular motors in fully synthetic (supra)molecular systems may confer them with some “active” functional properties, in striking contrast with the majority of today’s rather “passive” materials which are engineered and used in (meta)stable states. However, artificial molecular machines have been mainly studied so far as molecular switches, which simply influence their surrounding as a function of their isomerization states (typically A vs B). The objective of the SPRING project is to unambiguously show that the unidirectional motion of artificial molecular motors can be usefully implemented in supramolecular and macromolecular systems and materials, in order to drive them energetically uphill and to subsequently produce non-trivial functions requiring dissipative out-of-equilibrium conditions such as: active morphing, active adaptation, and active propulsion. This will be achieved through advanced synthetic chemistry and a fundamental in-depth understanding of the (supra)molecular and macromolecular systems developed at all scales. If successful, the SPRING project will establish innovative concepts to elaborate (i) active (supra)molecular systems, (ii) new synthetic objects to study some fundamentals of complex matter, and (iii) new technologies to envision applications of molecular machines in the real world.

Keywords: molecular motors,out of equilibrium systems
Construction Of Novel CERTification methOds and means of compliance for disruptive technologies (CONCERTO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Aviation
Action type: Innovation actions
Partnership: CLEAN-AVIATION (JU-JTI)
Countries involved: France,Germany,Belgium,Netherlands,Slovenia,Spain,Ireland,Italy,Greece,Portugal,United Kingdom
Call: Novel Certification Methods and Means of Compliance for Disruptive Technologies (HORIZON-JU-Clean-Aviation-2022-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 25189150.74
EU funding (EUR): 20094268.79
Participants: 33
Project status: SIGNED

Clean Aviation’s ambition to go over decisive impactful steps in demonstrated disruptive aircraft performance compatible with 2035 EIS will only be possible if the future regulatory framework is not an impediment to innovation. Certification shall still improve safety while shortening time to bring new safe products to market and into service, and maintaining European leadership and competitiveness. Having de-risked the certification path is an important step. The project will deliver a comprehensive set of regulatory materials on certification together with preliminary description of methods of compliance applicable to the three "thrusts" of Clean Aviation and a first status of comprehensive digital framework of formalized collaborative tooled and model/simulation-based processes for certification. Critical challenges, tackled through Proof of Concepts for the regional and short and medium range aircrafts, including hydrogen, will be easily transposable and scalable to different product lines and aircraft segments such as general aviation, rotorcraft, business jets or commercial medium-long range affecting the complete fleet. This initiative represents a tremendous opportunity to reinforce European leadership and sovereignty in leveraging our position as the forerunner of worldwide new certification frameworks. The composition of the project consortium reflects a smart mix of aircraft manufacturers (CS-25, CS-23), engine manufacturers (CS-E), equipment manufacturers, research centres, universities, SME and PLM experts. Playing a pivotal role between innovation and the development of safety, security or environmental protection standards, the involvement of EASA experts acting together with industrial and research technical teams for the conception, endorsement of new solutions and enhancement of the international community acceptance is also essential.

Keywords: certification,means of compliance,active wing,high voltage,hydrogen
Agile and Flexible Construction Materials Standardization for Boosting the Twin Transition (AFCOS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Coordination and support actions
Countries involved: Bulgaria,Romania,Italy,Belgium,Ireland,Croatia,Cyprus,Albania,Norway,Germany
Call: Pre-normative research and standardisation in industrial ecosystems (CSA) (HORIZON-CL4-2023-HUMAN-01, 2023)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 1199635.54
EU funding (EUR): 973746.25
Participants: 14
Project status: SIGNED

Over the past decades, European standards have delivered great benefits for companies and consumers on the single market. In the light of the social and environmental ambitions of the new growth strategy – the EU Green Deal – and the twin transition, Europe’s competitiveness, technological sovereignty and ability to reduce dependencies will directly depend on how successful European actors are in standardisation at international level. The EU Standardization Strategy from 2022 calls for more flexible and focused approach to standardization processes which can respond to the fast pace of twin transition innovating. The Agile and Flexible Construction Materials Standardization for Boosting the Twin Transition (AFCOS) project aims to set up recommendations, for more agile standardization processes for construction materials based on pre-normative research performed horizontally in a collaborative fashion between key ecosystem players – research, standardization and industrial actors from four member states – Bulgaria, Romania, Italy and Belgium. AFCOS will focus on identified standardization urgencies within the industrial ecosystem of construction and more specifically on standards supporting low carbon cement. Building on a set of activities combining research work with stakeholder engagement, educational activities and ambitious exploitation initiatives, AFCOS will produce roadmaps for pre-standardization, educational and training courses, strategy for education and skills development in the field of standardization of new building materials and exploitation models for the benefit of the European Standardization Organizations (ESOs), national standardization bodies, educational institutions and industry. AFCOS brings together 7 full and 5 associated partners from 9 EU countries encompassing research capacity, standardization expertise and industry representation and ecosystem actors, ensuring EU coverage and exploitability of the project results to a high level.

Keywords: standartization construction building materials twin transition
Understanding Corporate Taxation (U-CORP-TAX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: CLOSED

Corporate taxation is a key area of policymaking. It will be at the heart of many economic policies in the years to come to bring tax revenues or incentivize firms' behavior, in particular in the context of the European Green Deal. However, little is known about how firms react to changes in the corporate tax environment, especially when it comes to micro-level evidence. Among all firms, the reaction of large ones is of key importance because they account for an important share of economic activity and have more margins of adaptation than smaller firms. In particular, they can move their profits to tax havens to decrease their tax bill. More empirical evidence is needed to understand how corporate taxation affects these firms. To evaluate the impact of future reforms, it is crucial to know how firms will react on different margins: the level of production, the wages they pay, their investment, the location of their profits. Knowing the elasticity of these variables to taxation is key to understanding corporate tax reforms and will contribute to knowledge-based policymaking. The importance of these reactions cannot be overstated: they affect public finance and the provision of public goods, have macroeconomic impacts and have political and distributional consequences. U-CORP-TAX aims to contribute empirically and theoretically to understanding large firms’ responses to corporate taxation. To do so, U-CORP-TAX will leverage a unique research design, the exceptional additional taxation of large firms in France from 2011 to 2016. I will first merge administrative datasets providing precise firm-level data on profits, employment, investment, and wages. I will then use frontier causal inference methods to explore firms' responses to taxes on different margins. Finally, I will build a theoretical framework to interpret the empirical results and provide additional results about the distributional effects of corporate taxes.

Keywords: corporate income tax,tax havens,tax reforms,corporate tax incidence,firms reaction to taxes
PREDICTION OF ALZHEIMER’S DISEASE USING AN AI DRIVEN SCREENING PLATFORM (PREDICTOM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Innovative Health Initiative
Action type: Research and Innovation actions
Partnership: IHI (JU-JTI)
Countries involved: Norway,Denmark,Germany,Hungary,France,Belgium,Spain,United States,Netherlands,United Kingdom,Switzerland,India,Greece,Austria,Luxembourg
Call: Screening platform and biomarkers for prediction and prevention of diseases of unmet public health need (HORIZON-JU-IHI-2022-03-single-stage, 2022)
Start date: 2023-11-01
End date: 2027-10-31
Duration (months): 48.0
Total project cost (EUR): 17558485.3
EU funding (EUR): 8449326.38
Participants: 37
Project status: SIGNED

Alzheimer’s disease (AD) and related disorders leading to dementia are associated with staggering costs and suffering. Recently, there has been some progress in the search for effective therapeutic interventions and it is clear that any treatment is likely to be most effective if administered at the earliest stage of disease, but the health care system is not ready for this new scenario. There is an urgent need, therefore, to establish scalable, cost-efficient diagnostic markers, tools and procedures that can identify people at increased risk, at point of care for stratification into personalized interventions to prevent or delay dementia. PREDICTOM will develop an open-source, interoperable and customisable biomarker screening platform, utilizing an existing online resource to save time and money, to generate an evidence base for general population screening for AD and related disorders. We will bring diagnostics closer to the patient by examining the feasibility of using samples which can be obtained at home (e.g. finger-prick blood, saliva (for genetics and epigenetics) and stool for microbiom) for diagnostic biomarker analysis. We will also evaluate innovative technologies for disease risk identification, including digital technologies and novel MRI, EEG, eye tracking, and blood-based biomarkers. The platform will use artificial intelligence models to analyse data from all biomarkers to identify users at high risk of developing dementia and to direct them to personalized intervention to prevent further cognitive decline and development of dementia. We will seek to facilitate a change in current healthcare practice for early diagnosis of AD through development of new clinical practice guidelines based on evidence generated in the project. By improving the ease of identification of those with early signs of dementia we expect to have a significant impact on personal and financial burden of dementia in Europe and across the world.

Keywords: alzheimer s disease dementia biomarker accessibility digital biomarkers artificial intelligence blood based biomarkers mri eeg platform screening
Highly Efficient and Lightweight Input/output Open Silicon (HELIOS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,Spain
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-07-01
End date: 2026-09-30
Duration (months): 51.0
Total project cost (EUR): 3582501.25
EU funding (EUR): 2500000.0
Participants: 3
Project status: SIGNED

SiPearl was spun off from the European Processor Initiative (EPI) with €7.4m of initial funding to develop high-end microprocessors and protect European chip sovereignty. In the past 2 years, SiPearl has partnered and contracted with Arm and other top-tier IP providers, secured a €4.6M order book and identified a €1.1Bn sales pipeline in Europe alone. SiPearl is currently raising an €80M+ Series A. We are confident to close this round by year-end based on the achievements of the past 3 months: lead term sheet from a lead corporate investor of our industry, 25M€ venture loan from the EIB, €15M follow-on grant from EPI and additional LOIs from several corporate and public investors. We are currently hiring 7-10 employees per month in Europe. This funding application relates to an additional €2.5M EIC grant + €15M EIC equity which is meant to support the development of our next generation HELIOS platform architecture that supports the new European Chips Act by reducing the cost and time of new chip designs.”

Keywords: data centers,hpc,microprocessor,chiplet