Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ultrafast Structural Dynamics of Elementary Water-Mediated Proton Transport Processes (XRayProton)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-09-01
End date: 2024-08-31
Duration (months): 72.0
Total project cost (EUR): 2482500.0
EU funding (EUR): 2482500.0
Participants: 1
Project status: SIGNED

How acids and bases react in water is a question raised since the pioneering days of modern chemistry. Recent decades have witnessed an increased effort in elucidating the microscopic mechanisms of proton exchange between acids and bases and the important mediating role of water in this. With ultrafast spectroscopy it has been shown that the elementary steps in aqueous proton transfer occur on femtosecond to picosecond time scales. Aqueous acid-base neutralization predominantly proceeds in a sequential way via water bridging acid and base molecules. These ultrafast experiments probing molecular transitions in the ultraviolet, visible and mid-infrared spectral ranges, though, only provide limited insight into the electronic structure of acids, bases and the water molecules accommodating the transfer of protons in the condensed phase. Soft-x-ray absorption spectroscopy (XAS), probing transitions from inner-shell levels to unoccupied molecular orbitals, is a tool to monitor electronic structure with chemical element specificity. The aim is now to develop steady-state and time-resolved soft-x-ray spectroscopy of acids and bases in water-poor and water-rich solutions. Here novel liquid flatjet technology is utilized with soft-x-ray sources at synchrotrons as well as table-top laser-based high-order harmonic systems, to elucidate the electronic structural evolution of proton transfer pathways. Questions to be solved are electronic structural changes upon hydrogen bond formation, the nature of hydrated proton species, and the impact of conversion from acid to conjugate base (or base to conjugate acid) in aromatic alcohols, carboxylic and amine compounds, and ultimately the oxygen oxidation state in hydrated protons. Resolving the electronic structural dynamics of elementary steps of aqueous proton transport will furthermore elucidate the role of mediating water in bulk solution, and in specific conditions such as hydrogen fuel cells or trans-membrane proteins.
Boosting the Performances of Wind Turbines thanks to Microstructure Coating (MicroCoating)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-04-01
End date: 2019-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The wind energy market is developing quickly and it will produce 15% of the EU’s electricity demand by 2020, avoiding 333 million tonnes of CO2 per year and saving Europe €28 billion a year in fuel costs. Yet, it struggles to find innovations that can reach the market soon, with little costs, and that be used on existing turbines. We address this need via a novel coating technology that we have developed in house and patented. In short, we create microstructures on the wind turbine blades in order to reduce their air resistance. These microstructures are grooves that channel the air turbulence on the surface thus improving the aerodynamics. Our innovation is perfectly suited to wind turbines blades, since it helps to increase their efficiency without changing their shapes or manufacturing process, and it can be even used on existing wind turbines, simply by recoating them. We are currently at TRL 6, we filed one patent in 2018 and performed an extensive Freedom to Operate analysis, with positive results. Our customers are the manufacturers of wind turbines, who want to create a better product without re-engineering the blades, and the Operations and Maintenance companies of wind farms, who want to improve the performances of existing wind turbines. The Total Addressable Market is over €1.76 billion. Our first sale will happen in December 2020 but we are already commercializing the printing system without the full capabilities of microstructure coating in order to gain revenues and reputation. In our commercial strategy, we will first address five countries that are promising (UK, Germany, Denmark, Belgium, the Netherlands) because of the maturity of the wind turbine market to then expand to the rest of the EU, and eventually to the whole world. According to our forecasts, our turnover will reach €16 million at the end of 2022. We are a woman-led team of 9 people, all with at least a master degree, with complementary expertise in engineering and business.

Keywords: wind turbines,coating,functional coating
The Effect of Manifestations of Religion in the Public Space on Sociopolitical Integration of Minority-Religion Immigrants (ReligSpace)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Israel
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-04-01
End date: 2024-03-31
Duration (months): 60.0
Total project cost (EUR): 1499625.0
EU funding (EUR): 1499625.0
Participants: 1
Project status: SIGNED

Recent globalization and immigration trends are motivating tremendous efforts to regulate manifestations of minority religions in the public space, such as religious structures, stores, attire, and rituals (hereafter, spatial religious manifestations). Yet the empirical literature has, to date, not taken on the methodologically and conceptually challenging undertaking of theorizing, operationalizing, and assessing this dimension of religion. In particular, it remains unclear what causal effect manifestations of religion in the public space have on minority-religion immigrants’ sociopolitical integration: do they, by validating immigrants’ identity, facilitate a sense of belonging and the endorsement of local practices, or nurture alienation and hostility toward the host society? Integrating up-to-date theories and methods from political science, psychology, sociology, and geography, and optimizing external and internal validity, this project is the first large-scale research to examine the causal effect of exposure to spatial religious cues on sociopolitical integration, studying minority-religion immigrants of the three monotheistic religions in four urban settings. The research will be divided into three work packages: (1) conceptualization and operationalization of spatial religious manifestations; (2) comparative naturalistic and survey-embedded experiments examining the effect of real-world spatial religious cues on minority-religion immigrants’ sociopolitical integration; and (3) a panel survey with longitudinal geocoded data analyzing the conditions in which spatial religious cues are particularly instrumental in local-level integration. Besides developing a novel approach to the study of religion in politics, this project will open new horizons in the understanding of aggregated religious priming effects in real-world settings, with insights into the dynamics that would advance a more inclusive society via nuanced policies and informed urban planning.
Policy, Expertise, and Trust in Action (PERITIA)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Armenia,Italy,Ireland,Norway,Poland,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Trust in governance (H2020-SC6-GOVERNANCE-2019, 2019)
Start date: 2020-02-01
End date: 2023-05-31
Duration (months): 40.0
Total project cost (EUR): 2994596.25
EU funding (EUR): 2994596.25
Participants: 11
Project status: SIGNED

Many policy decisions in contemporary knowledge-based forms of governance are driven by advice, evidence and data provided by experts from diverse arenas. In democratic societies, trust in the provenance and justification of policy measures are essential for their implementation. The rise of populist politics with its anti-elitist mantra has brought the trustworthiness of experts and their areas of expertise into question. PEriTiA brings together philosophers, social and natural scientists, policy experts, ethicists, psychologists, media specialists and civil society organisations to conduct a comprehensive multi-disciplinary investigation of trust in and the trustworthiness of policy related expert opinion. The investigation is carried out in three - theoretical, empirical and ameliorative – phases with the goal of illuminating a topic that has been the subject of much political commentary and media debate in recent years. The key hypothesis explored conceptually and tested empirically is that affective and normative factors play a central role in decisions to trust, even in cases where judgements of trustworthiness may seem to be grounded in epistemic considerations, such as professional reputation, reliability and objectivity. The most ambitious feature of the current project is the application of its theoretical and empirical findings to active attempts at establishing trust, where warranted, between the general public and actors with a central role in the decision-making processes of governance. Our ultimate aim is to provide tools and discover indicators which can be used in measuring and establishing the trustworthiness of the agents involved in social and political decision making. The use of climate change and climate science as a test case in exploring the social, ethical and psychological indicators of trustworthiness is expected to help to construct trust-enhancing narratives regarding the role of science in governance.

Keywords: trustworthiness,policy,epistemic,emotions,social epistemology,ethics,nudge,social indicators,science
National Contact Points for quality standards and horizontal issues (NCP ACADEMY)

Framework: Horizon 2020 — Science with and for Society
Programme: Develop the governance for the advancement of responsible research and innovation by all stakeholders, which is sensitive to society needs and demands and promote an ethics framework for research and innovation
Action type: Coordination and support actions
Countries involved: Austria,Germany,Spain,Italy,Ireland,Switzerland,Belgium,Finland,Finland,Croatia,Moldova, Republic of,Greece,Poland,France,Czechia,Portugal,Denmark,Portugal
Call: National Contact Points for quality standards and horizontal issues (H2020-GARRI-NCP-2014-1, 2014)
Start date: 2014-12-10
End date: 2018-06-09
Duration (months): 42.0
Total project cost (EUR): 1967828.0
EU funding (EUR): 1967828.0
Participants: 20
Project status: CLOSED

National Contact Points (NCPs) will play a key role in Horizon 2020 as providers of information and assistance to potential applicants and project beneficiaries. They constitute the main interface to the European R&D community for Member States and Associated Countries and the European Commission. While their activities are underpinned by the European Commission’s “Guiding principles for setting up systems of national contact points”, NCPs are appointed and financed at national level so that existing NCP systems show a wide variety of architectures and ways of working. This project aims to create and implement a new and integrated training of Horizon 2020 advisors – the NCP Academy. It brings together NCP Coordinators and NCPs for Legal and Financial aspects of Horizon 2020 to develop the NCP Academy concept and to develop and implement training courses on cross-cutting issues. It addresses quality standards and good practice as well as routes to feedback and communication for this community. In doing so it aims to significantly enhance the performance of NCPs and does so by harnessing the knowledge base already existing within this community. It will be responsive, addressing new issues that emerge during implementation of the Horizon 2020 programme and it will be all-inclusive, providing training to all NCPs, and especially targeting new and/or less experienced NCPs. The consortium will work closely with existing thematic NCP Networks, carefully serving their needs for cross-cutting aspects of Horizon 2020. Expected impacts include achievement of an improved and professionalised NCP service across Europe, thereby helping simplify access to Horizon 2020 calls.

Keywords: national contact points,training,cross cutting issues
Mechanical Behavior of Microscale Metallic Wires under Torsional and Tensile Loadings at Elevated Temperatures (TORWIRE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-08-01
End date: 2018-01-31
Duration (months): 18.0
Total project cost (EUR): 146591.1
EU funding (EUR): 146591.1
Participants: 1
Project status: CLOSED

The size effects (smaller is stronger) and Bauschinger effects (plastic recovery) at room temperature have been extensively documented experimentally at the micro/nano-scale. However, the underlying deformation mechanisms remain ambiguous, particularly in the presence of strain gradients. In this project, we intend to develop an integrated micro-torsion and micro-tension technique with a heating and temperature-control element for investigating the mechanical behavior of micro-scale metallic wires/tubes at elevated temperatures. We study all three size effects, due to the grain size, due to nonuniform deformation, and due to the wire diameter, and their coupling effects, using samples with different diameters (or wall thickness) and controlled grain sizes. The Fellow has reported the first observation of anomalous plasticity in the cyclic torsion of micro-scale metallic wires at room temperature. However, there have been no reports on the phenomenon in the cyclic torsion of small volumes at elevated temperatures. In this proposal, we plan to perform the (cyclic) torsion tests on micron-scale metallic wires and tubes which are heated in situ by passing an electrical current, and then to analyze the relation between plastic recovery and temperature. A long term goal is to exploit the size effect in novel high-strength, lightweight materials through “length-scale engineering”. The main objectives are: • To integrate the different micro-torsion/tension experimental methods, and so that it can be used at high temperatures. • To perform (cyclic) torsion and tension tests on thin metallic wires/tubes at elevated temperature. • To integrate the complementary theoretical methods, used to understand the corresponding physical mechanisms for the observed phenomena. • To test existing theories for micro-scale plasticity by using the homemade samples, e.g. thin wires/tubes prepared with different grain sizes and diameters.

Keywords: size effect,plasticity,strain gradient plasticity,bauschinger effect,torsion test,thin wires
Scaling up Safe Surgery for District and Rural Populations in Africa (SURG-Africa)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Research and Innovation actions
Countries involved: Ireland,Zambia,Tanzania, United Republic of,Netherlands,United Kingdom,Malawi
Call: Implementation research for scaling-up of evidence based innovations and good practice in Europe and low- and middle-income countries (H2020-SC1-2016-RTD, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 5997813.0
EU funding (EUR): 5997813.0
Participants: 7
Project status: CLOSED

In sub-Saharan Africa 95% of the population has no access to surgical services. In this region surgery – a proven and often life-saving intervention – is only accessible to urban populations, with only one surgeon per 2.5 million people in rural areas. Emerging evidence demonstrates that major surgery can be undertaken safely and effectively at district hospitals, making it accessible to otherwise neglected rural populations. Objectives: Guided by a health systems-strengthening framework and a comprehensive programme of research, Scaling up Safe Surgery for District and Rural Populations in Africa will scale up the delivery of accessible, elective and emergency surgery at district hospitals to national level programmes in three African countries: Malawi, Zambia and Tanzania. How objectives will be achieved: SURG-Africa is a tested intervention, drawing lessons from two large-scale successful interventions coordinated by members of this SURG-Africa consortium (one FP7 EC funded) that have trained and supervised non-physician clinicians to deliver essential and emergency surgery in four African countries. Platformed on comprehensive surgical systems analyses, it will put in place national surgical information systems; and will test innovative interventions for making specialist supervision of district surgery feasible and affordable. Epidemiological, economics and implementation research will evaluate impact, and provide evidence for policymakers. SURG-Africa directly addresses all aspects of Topic SC1-PM-21-2016: Implementation research for scaling- up of evidence based innovations and good practice in Europe and low and middle-income countries. The results will be transferable and scalable national surgical systems models, with implications for national budget factored in, for making safe surgical services accessible, equitable and sustainable in Africa, especially for women in rural areas.

Keywords: surgery,district hospital,africa
Pulsehaler™ - A Breakthrough Treatment for COPD (OPEN-LUNGS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 1257822.5
EU funding (EUR): 880475.75
Participants: 1
Project status: SUSPENDED

Chronic Obstructive Pulmonary Disease (COPD) is a progressive, debilitating, disease of the lungs which affects 50M Europeans and kills 160,000 every year, with an annual cost burden of €141B. Respinova Ltd. has developed a novel device, called Pulsehaler™, to treat COPD in a revolutionary way by re-opening the small airways which are known to collapse in COPD patients thereby making it increasingly difficult to breathe. No other COPD treatment in the market today can effectively open these airways. In a clinical trial, PulseHaler™ was shown to substantially improve exercise capacity (the strongest predictor of morbidity and mortality), breathing ability, and quality of life of COPD sufferers. If Pulsehaler™ can reduce costs by the same magnitude to which it has been demonstrated to improve patients’ exercise capacity, the current cost burden of COPD in Europe could be reduced by up to €21B annually. We intend to complete several actions in this project which will bring Pulsehaler™ to the commercial market, and allow Respinova to scale up into a world leader in treating respiratory diseases. A multicenter international clinical trial will be conducted to further build data on Pulsehaler efficacy and support marketing launch. We will obtain CE Mark regulatory approval, and proceed to launch the Pulsehaler™ in the market, scaling up sales, marketing, and production. Respinova Ltd. is a SME based in Israel with 12 employees currently. We have a seasoned management team with decades of combined medical device, business and leadership experience. We are a Horizon 2020 SME Phase II SME grant winner, and two-time EIC Seal of Excellence winner, for our Pulsehaler™ technology.

Keywords: chronic obstructive pulmonary disease,coronavirus,covid 19,respiratory disease,lung disease,medical,device,airway constriction,small airways,loss of lung function
PReterm Enteroids to determine the Mechanism of Necrotising EnteroColitis (PREMNEC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2020-06-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Necrotising enterocolitis (NEC) is an inflammatory mediated bowel disease that causes more deaths after the first week of life in extremely preterm infants than any other single pathology, with prematurity and abnormal bacterial colonisation regarded as the most significant risk factors. However, 40 years of research have yielded few advances in treatment and the mechanisms of disease remain poorly understood. A major reason for this lack of progress relates to challenges in translating findings from non-invasive samples (e.g., stool) and the inability to robustly model bacterial-host crosstalk. To overcome this longstanding hurdle, the proposed PREMNEC (PReterm Enteroids to determine the Mechanisms of Necrotising EnteroColitis) fellowship will utilise a novel ex vivo preterm human intestinal enteroid (PHIE) co-culture model to systematically explore the gut microbiome and host functioning in preterm infants. The fellowship is divided in three distinct work packages (WPs). In WP1, surgically resected intestinal tissue (otherwise discarded) from NEC and non-NEC infants will undergo characterisation utilising metagenomics, transcriptomics, proteomics, and cellular imaging directly on the fresh tissue. Concurrently, WP 2 will isolate crypt cells from the tissue to establish PHIEs that permit accurate and reproducible ex vixo co-culture of bacterial-host interaction. In WP 3, bacterial species isolated from preterm infants will be systematically added to the ex vixo co-culture model and comparable technologies utilised in WP 1 will be applied to determine the pathobiology of disease. Newcastle University will provide expertise in state-of-the-art transcriptomics and cellular imaging technologies. Upon completion of this 24-month fellowship, I will have pioneered significant advancement in the mechanistic understanding of microbial-host interaction in the pathogenesis of NEC and identified potentially beneficial bacteria that may provide protection from NEC.

Keywords: preterm,gut microbiome,health and disease,mechanism,necrotising enterocolitis,human intestinal enteroid,metagenomics,transcriptomics,proteomics