Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A revolutionary direct, daily heart monitoring platform for long-term tailored treatment of Heart Disease patients. (V-LAP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 2621146.25
EU funding (EUR): 1834802.38
Participants: 1
Project status: CLOSED

Heart failure (HF) is a chronic condition affecting 1 in 5 people aged over 65 worldwide: heart is unable to pump enough blood flow to meet the body needs. The resulting excess of fluids in body and organs causes dyspnea, edema, leg swelling and tiredness, decreasing patients’ life quality. The sudden worsening of symptoms is called Acute Decompensate Heart Failure: a life-threatening condition with 30% mortality within 12 weeks. HF costs are high: 28 B€/year to EU NHS, 2% of total healthcare expenditure, the major part due to hospitalization. There is today a global call to increase awareness in HF, whose management is still highly ineffective. The transition from HF to the acute condition takes weeks but its earliest indicator, an increase in left ventricular filling pressure (LV), can only be measured invasively, in a hospital. Vectorious’ disruptive device is a miniaturized, battery-free, implantable hemodynamic monitor capable of detecting the rise in LV during patient’s daily life. The implantable, completely covered by Vectorious’ patents portfolio, is deployed through a minimally invasive, catheter-based procedure. A belt-like external device is worn by the patient over the clothes 3 min/day: via inductive AC coupling, the implantable is powered so pressure data can be collected and sent back to the external unit which synchronize with the patient’s mobile device and with a dedicated website for the healthcare provider. A green/yellow/red color code widely known among HF patients allows them to promptly adjust their medications, according with their clinicians’ prescription. V-LAP will be able to predict at least 98% ADHF events, HF management will become as simple as manage glucose levels in diabetes.

Keywords: heart failure,hemodynamic monitor,implantable device,personalised medicine,wellbeing,medical device,atrial pressure
Digital platform for hands-on cybersecurity training (ADVERSARY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Iceland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-11-01
End date: 2019-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The cybersecurity panorama is alarming: cyberattacks in EU are costing businesses approx. €208 billion/year (1.6% of GDP), i.e. around €1.6 to €10.8 million per company. Indeed, 97% of companies are breached, only 53% of attacks are detected by internal resources and each attack takes a mean time of 99 days to be detected. Even though 90% of costs derived from cyberattacks are caused by vulnerabilities in production systems, companies still pose a reactive attitude towards attacks: 90% of them consider security an afterthought, trying to patch the eventual vulnerabilities once the system has been developed; and common security controls are focused on ‘firefighting’ attacks towards systems in the production stage instead of preventing them. However, each defect in a production system costs up to 95 times more than in the development stage, so it is clear that a more preventive approach for cybersecurity would decrease by orders of magnitude the damages caused by attacks by unveiling in earlier stages the vulnerabilities of IT systems. In order to solve these problems, ADVERSARY is a novel cybersecurity platform that helps companies minimising vulnerabilities from the very early stages of development, thanks to effective training of IT Managers and SW Developers. Our platform provides tools for hands-on cybersecurity training through a gamified experience that fosters participation, comprehension and reduces drop-outs. These activities are performed in real environments where users can experience different phenomena, and this active learning has shown to be 80% to 800% more effective for acquiring knowledge and skills. By receiving proper training on cybersecurity, our users are able to prevent vulnerabilities from the early stage of development, minimising the greater damage caused in the later stage of production.

Keywords: cybersecurity trainning,collaborative intelligence,vulnerability,hands on cybersecurity,gamified experience,real environments
A disruptive Magnetically Enhanced Library preparation platform for Next Generation Sequencing (MAGELIA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-08-01
End date: 2021-09-30
Duration (months): 26.0
Total project cost (EUR): 2793000.0
EU funding (EUR): 1955100.0
Participants: 1
Project status: CLOSED

Inorevia is a spin-off from the Institut Curie/CNRS (Paris) that leverages over ten years of research in microfluidics to tackle challenges of modern Biology and Medicine with faster, cheaper, miniaturised sample preparation. Inorevia’s ground-breaking biology platform, the MAGELIA, will provide Biologists and Clinicians with a unique tool to efficiently process raw biological samples upstream of advanced analysis methods such as Next-Generation Sequencing (NGS) in volumes 100 to 1000 times smaller, in an entirely automated platform. After over 2 years of R&D and a first TRL6 prototype of the MAGELIA platform, Inorevia is ready to accelerate its development to reach TRL8, finish the development of the MAGELIA and initiate its commercialization by 2021. Aiming for the NGS sample preparation market, this first generation of the MAGELIA platform will meet the needs of low to medium throughput labs, sequencing platforms, biotech and pharmacy companies, who struggle with low-reproducibility manual library preparations, expensive reagents, and scarce biological samples. The MAGELIA platform will democratise NGS to ignite a revolution in genomics on a fast-growing 8 Billion € market. To succeed, Inorevia has put together an 8 persons’ team of recognized scientists, engineers, and confirmed business talents, backed by a renowned advisory board. The company holds exclusive rights on 4 key patents and large know-how. Since its inception in 2016, Inorevia has won several renowned awards in France and Europe, secured over 1.3 M€ in grants and a seed round. The MAGELIA SME Instrument Phase 2 project specifically aims at accelerating Inorevia’s go-to market through faster development, earlier pre-series and larger market reach in Europe. With the objective to reach over 400 customers and 15% of the European market within five years, with a turnover of 30 M€, INOREVIA will become the European leader in miniaturized samples preparation for modern biology and medicine.

Keywords: genomics,industrial biotechnology,biological engineering,new generation sequencing,sample preparation,microfluidics,dna analysis
EXpansion and Phenotype Loss Of SMCs In Atherosclerosis: Causal effects and therapeutic possibilities (EXPLOSIA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Spain,Denmark
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-08-01
End date: 2025-07-31
Duration (months): 60.0
Total project cost (EUR): 1998875.0
EU funding (EUR): 1296120.0
Participants: 2
Project status: SIGNED

Atherosclerosis is considered an inflammatory disease caused by the accumulation, modification and immune cell recognition of low-density lipoproteins in the arterial wall. Plaque macrophages are held to be the main drivers of disease activity, whereas smooth muscle cells (SMCs) have traditionally been considered protective by forming fibrous tissue that stabilises plaques from undergoing rupture and causing thrombosis. In the present project, we challenge this dichotomous view of cellular villains and heroes in atherosclerosis. Using lineage tracking techniques in mice, we and others have uncovered a large population of SMCs in plaques, which has escaped detection because the cells completely lose conventional SMC phenotype. Strikingly, we have found that the entire plaque SMC population derives from only few founder SMCs that undergo massive clonal expansion and phenotypic modulation during lesion formation. We hypothesise that the balance between the different modulated SMC subtypes and the functions they carry are central to lesion progression. In EXPLOSIA we will address this hypothesis in 3 steps. First, we will conduct a comparative analysis of clonal structure in mice, minipigs, and humans. Second, we will determine links between SMC subtypes, their gene expression programs, and atherosclerotic disease activity by combining single-cell transcriptomics with novel techniques to alter atherosclerotic disease activity in gene-modified mice and minipigs. Third, we will develop techniques for manipulating genes in modulated plaque SMCs and test the causal role of perturbing SMC subtypes and function for lesion progression. The aim of the project is to answer the following key questions for a deeper understanding of atherosclerosis: - What is the clonal architecture of SMCs in human atherosclerosis? - What is the SMC gene expression signature of atherosclerotic disease activity? - Can interventions targeting SMCs prevent dangerous lesion development?

Keywords: atherosclerosis,smooth muscle cells,experimental animal models
Defining mechanisms of cellular stress responses driven by heterotypic ubiquitin chains (StressHUb)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2185859.0
EU funding (EUR): 2185859.0
Participants: 1
Project status: SIGNED

Posttranslational modification of proteins with monoubiquitin or different polyubiquitin chains alter protein function to signal distinct responses in cells and thereby regulate every aspect of eukaryotic biology. Recently, ubiquitin has also been reported to form branched heterotypic chains. The central premise of this proposal is that branched ubiquitin chains adopt unique conformations and convey distinct intracellular signals essential for maintaining cellular homeostasis. We posit that branching of homotypic ubiquitin chains or de novo formation of branched structures occurs in response to specific cues and they serve as priority signals to mediate prompt cellular responses. The complex nature of branched heterotypic ubiquitin, the lack of tools to specifically and efficiently probe different branched ubiquitin structures and the relatively low abundance of these chains in a cell make it challenging to study them. In this proposal, I will describe an ambitious approach to define how branched ubiquitin serve as unique signals to elicit cellular stress responses. To attain these goals, we will pioneer the development of novel designer tools and methods, which we will combine with quantitative proteomics, single cell analyses, biochemistry and structural biology. We will elucidate the molecular players involved in the assembly, decoding and regulation of branched ubiquitin. We will develop approaches to monitor branched ubiquitin formation in cells to identify stress conditions that trigger formation of branched ubiquitin chains. We will functionally characterize how distinct branched heterotypic ubiquitin signals are formed in response to stress and serve as priority signals to trigger stress-response pathways. Our work will shed light on fundamental principles of intracellular signalling and mechanisms that maintain cellular homeostasis.

Keywords: ubiquitin,deubiquitinases,ubiquitin ligases,ubiquitin signalling,cellular homeostasis,signal transduction mechanisms
Musicians in the “Republic of Letters”: For a Social Network Analysis of Giambattista Martini’s Correspondence (MARTINET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2025-01-31
Duration (months): 36.0
Total project cost (EUR): 269002.56
EU funding (EUR): 269002.56
Participants: 2
Project status: SIGNED

Handwritten correspondence was a vital means of communication during the 18th Century. Through their letters, people kept in touch with family and friends, exchanged information, sought patronage, and did business. Musicians’ correspondence bears witness to every aspects of musical life, as well as to socio-economic issues related to music production and consumption. The overarching-project objective is to create a representation of 18th-century European musical environment through the reconstruction and analysis of the correspondence and epistolary network that Franciscan friar Giambattista Martini (1706-1784) entertained with musicians, music lovers, scholars and editors, men and women, from across Italy and from Europe’s most important courts and musical centers. Until now, research has been restricted only to the 6,000 letters received from some 970 correspondents collected in Martini's library. No serious attempt has been carried out to gather the huge number of letters that he sent to his correspondents, hosted in many libraries, archives and private collections on a global scale. Moreover, the methodologies followed have reduced epistolary content to a static dataset, not considering that it is the output of dynamic social network, requiring a philological, historical, and sociological approach within the epistemological framework provided by digital humanities. The research will focus on an extensive archival investigation on a global scale and a detailed indexation to identify the key themes of the correspondence. Finally, specific topics of the correspondence will be categorised applying the Social Network Analysis tools. Under the supervision of internationally renowned specialists of modern history of music and culture, the MSCA-GF will be implemented by a fellow with skills in 18th century musicians’ correspondence analysis, and provide him outstanding training in digital humanities and social network analysis to develop an excellent research profile.

Keywords: giambattista martini,music history,musicology,18th century music,republic of letters,musicians,correspondence,epistolary network,digital humanities,social network analysis
Analysis of quantum many-body systems (AQUAMS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Austria
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-03-31
Duration (months): 66.0
Total project cost (EUR): 1497755.0
EU funding (EUR): 1497755.0
Participants: 1
Project status: CLOSED

The main focus of this project is the mathematical analysis of many-body quantum systems, in particular, interacting quantum gases at low temperature. The recent experimental advances in studying ultra-cold atomic gases have led to renewed interest in these systems. They display a rich variety of quantum phenomena, including, e.g., Bose–Einstein condensation and superfluidity, which makes them interesting both from a physical and a mathematical point of view. The goal of this project is the development of new mathematical tools for dealing with complex problems in many-body quantum systems. New mathematical methods lead to different points of view and thus increase our understanding of physical systems. From the point of view of mathematical physics, there has been significant progress in the last few years in understanding the interesting phenomena occurring in quantum gases, and the goal of this project is to investigate some of the key issues that remain unsolved. Due to the complex nature of the problems, new mathematical ideas and methods will have to be developed for this purpose. One of the main question addressed in this proposal is the validity of the Bogoliubov approximation for the excitation spectrum of many-body quantum systems. While its accuracy has been successfully shown for the ground state energy of various models, its predictions concerning the excitation spectrum have so far only been verified in the Hartree limit, an extreme form of a mean-field limit where the interaction among the particles is very weak and ranges over the whole system. The central part of this project is concerned with the extension of these results to the case of short-range interactions. Apart from being mathematically much more challenging, the short-range case is the one most relevant for the description of actual physical systems. Hence progress along these lines can be expected to yield valuable insight into the complex behavior of these many-body quantum systems.

Keywords: quantum statistical mechanics,schr dinger equation,bose einstein condensation,phase transition,spectral analysis,bogoliubov approximation
Establishing services enhancing the innovation management capacity of SME´s in Hamburg and Schleswig-Holstein (INNOKAM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany,Germany
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-05-01
End date: 2014-12-31
Duration (months): 8.0
Total project cost (EUR): 48375.0
EU funding (EUR): 38700.0
Participants: 3
Project status: CLOSED

The three partners Investitionsbank Schleswig-Holstein (IB.SH), TuTech Innovation GmbH (TuTech) and Wirtschaftsförderung und Technologietransfer Schleswig-Holstein (WTSH) are part of the Enterprise Europe Network(EEN) consortium in Hamburg and Schleswig-Holstein and established a well-known regional one-stop-shop for all EU-related enquiries for SMEs and regional stakeholders. For the period 2014 core objective is to expand the client base and deepen the level of assistance by offering the new service of “Key Account Management” (KAM) and “Enhancing SME Innovation Management Capacity” (IMC). Aim is to face existing lack of innovation management capacity in small and medium sized companies (SME) and support their innovative activities in order to creating economic impact (competitiveness, growth and jobs). The guiding principle is that the services will be tailored to the needs of the identified regional innovators and innovation systems. In this context the KAM will be targeted at beneficiaries of the SME instrument under Horizon 2020, the IMC will address other highly innovative SMEs. The IMC will help companies to establish effective innovation management systems that enhance the realisation of growth opportunities. The KAM focuses on the those weaknesses which endanger the success of the funded project. It will assist in finding specialised coaches and establishing a coach-client relationship. Both approaches aim to raise the company´s competitiveness and profitability. In the framework of the project the consortium will acquire an annual user license for the IMP3rove tool in order to assess gaps and needs of the SMEs. In this context senior staff of the EEN will attend training to ensure that the tool is used correctly and the assessment exercise complies with the envisaged EU standard. In addition the participation in training courses gives the chance for a best practice exchange with other EEN colleagues and will be of great benefit for the consortium.

Keywords: innovation management capacity building,key account management,sme instrument,enterprise europe network,hamburg and schleswig holstein,germany
Towards New Generation of Solid-State Photovoltaic Cell: Harvesting Nanotubular Titania and Hybrid Chromophores (CHROMTISOL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Czechia
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-03-01
End date: 2020-08-31
Duration (months): 66.0
Total project cost (EUR): 1644380.0
EU funding (EUR): 1644380.0
Participants: 1
Project status: CLOSED

In photovoltaics (PVs), a significant scientific and technological attention has been given to technologies that have the potential to boost the solar-to-electricity conversion efficiency and to power recently unpowerable devices and objects. The research of various solar cell concepts for diversified applications (building integrated PVs, powering mobile devices) has recently resulted in many innovations. However, designs and concepts of solar cells fulfilling stringent criteria of efficiency, stability, low prize, flexibility, transparency, tunable cell size, esthetics, are still lacking. Herein, the research focus is given to a new physical concept of a solar cell that explores extremely promising materials, yet unseen and unexplored in a joint device, whose combination may solve traditional solar cells drawbacks (carrier recombination, narrow light absorption). It features a high surface area interface (higher than any other known PVs concept) based on ordered anodic TiO2 nanotube arrays, homogenously infilled with nanolayers of high absorption coefficient crystalline chalcogenide or organic chromophores using different techniques, yet unexplored for this purpose. After addition of supporting constituents, a solid-state solar cell with an extremely large incident area for the solar light absorption and optimized electron pathways will be created. The CHROMTISOL solar cell concept bears a large potential to outperform existing thin film photovoltaic technologies and concepts due to unique combination of materials and their complementary properties. The project aims towards important scientific findings in highly interdisciplinary fields. Being extremely challenging and in the same time risky, it is based on feasible ideas and steps, that will result in exciting achievements. The principal investigator, Jan Macak, has an outstanding research profile in the field of self-organized anodic nanostructures and is an experienced researcher in the photovoltaic field

Keywords: nanotubes,solar cells,charge carrier separation