Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Phytolith Analysis and Stone Tools: A socio-ecological analysis of stone tools assemblage of North-Western South Asia (PAST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-16
End date: 2022-10-15
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Very often disciplinary and historical inertias drive current research, producing contradictions between available data and their interpretation. Lithic tools, constituting one of the most important archaeological record, are understood as a primary evidence of technological innovation and have been traditionally associated with male labour. Yet to extract information about behaviour and ways of life from these tools is difficult. Thus, the aims of PAST are, 1) to develop a sound methodology for understanding the role of specific tools and the socio-cultural aspects related to the tool use (e.g., raw material exploitation, gender division of labour), 2) to further our knowledge of the socio-ecological dynamics of the Chalcolithic communities of north-western South Asia (4th-2nd millennium BCE) by adding the information extracted from the study of lithic assemblages of key-sites, 3) to understand the change in the types of tools and their archaeological significance (are there typological or functional changes with the changing life styles of people from hunting and gathering to agriculturalists?) Through an interdisciplinary approach, PAST integrates systematic sampling with laboratory techniques in microbotanical remains extraction and the analysis and ethnographic research on gender roles in lithic production and use, aiming at providing critical frames of reference. The interdisciplinary nature of the work provides a holistic understanding of the context, involving new strategies for sampling in the field and different cutting-edge laboratory techniques of microfossil analysis. PAST is thus expected to enhance understanding about agricultural practices and socio-ecological dynamics of past societies during a transitional time in human history and to pioneer the understanding of how technological innovation is approached by means of analysing the gender division in lithic production and use.

Keywords: lithic tools,indus valley civilization,phytoliths,south asia
Quantitative stochastic homogenization of variational problems (QSHvar)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Finland
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-08-01
End date: 2024-07-31
Duration (months): 60.0
Total project cost (EUR): 1312500.0
EU funding (EUR): 1312500.0
Participants: 1
Project status: SIGNED

The proposal addresses various multiscale problems which lie at the intersection of probability theory and the analysis of partial differential equations and calculus of variations. Most of the proposed problems fit under the framework of stochastic homogenization, that is, the study of large-scale statistical properties of solutions to equations with random coefficients. In the last ten years, there has been significant progress made in developing a quantitative theory of stochastic homogenization, meaning that one can now go beyond limit theorems and prove rates of convergence and error estimates, and in some cases even characterize the fluctuations of the error. These new quantitative methods give us new tools to attack more difficult multi-scale problems that have until now resisted previous approaches, and consequently to solve open problems in the field. Many of the actual goals of the proposal come from problems in calculus of variations. Apart from qualitative results, many fundamental questions in quantitative theory are completely open, and our recent results suggest a way to tackle these problems. The first one is to prove regularity properties of homogenized Lagrangian under rather general assumptions on functionals, and to solve a counterpart for Hilbert's 19th problem in the context of homogenization. The second project is to attack so-called Faber-Krahn inequality in the heterogeneous case. This is a very involved problem, but again recent development in the theory of homogenization makes the attempt plausible. The final part of the proposal involves new mathematical approaches and subsequent computational research supporting the geothermal power plant project being built by St1 Deep Heat Ltd in Espoo, Finland.
First scalable food-grade technology for the direct extraction and purification of miRNAs-rich extracts from plants (Mirnagreen)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-07-01
End date: 2019-11-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Non-communicable diseases (NCDs), such as cardiovascular diseases, cancers, chronic respiratory diseases, diabetes, pose a significant health and economic burden worldwide, accounting for more than 60% of all global deaths. Increasingly, health organizations, governments and citizens themselves are taking a more pro-active stand towards healthier lifestyles. Dietary intake of fruit and vegetables - whose daily consumption recommended by WHO is at least 400g - is a key effective factor in reducing NCDs and chronic inflammation-related mortality risks. The anti-inflammatory capacity of fruits and vegetables is attributable to their microRNAs, which are small non-coding RNA (sRNA). Nevertheless, despite their immunomodulatory action, the poor availability of microRNA in the normal diet make them insufficient to carry out this function. Mirnagreen is the most extensive and sustainable platform of all-natural, non-modified functional microRNA extracts, based on an exclusive and proprietary food-grade technology to extract and purify microRNA from plants. Mirnagreen technology can extract between 40 to 100 mg small RNAs per kg of fresh plant biomass in a purification cycle of less than 3 hours. The production process enables full valorisation of all residues in the food chain, as it derives from plant waste generated by local food producers. Mirnagreen’s manufacturing is fully sustainable and promotes circular economy. Mirnagreen is a radically new solution that can be integrated into a wide range of products. Go-to-market applications of our extracts are nutraceuticals and cosmeceuticals. Future applications will include agro stimulants, oral care, pet food and, eventually, drugs. The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of Mirnagreen and its market uptake.

Keywords: microrna,small rna,anti inflammatory,nutraceuticals,cosmeceuticals,biomass,circular,economy
The Crosstalk Between Red And White Blood Cells: The Case Of Fish (BLOODCELLSCROSSTALK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Spain
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2020-10-31
Duration (months): 67.0
Total project cost (EUR): 1823250.0
EU funding (EUR): 1823250.0
Participants: 1
Project status: CLOSED

Fish are the phylogenetically oldest vertebrate group with an immune system with clear similarities to the immune system of mammals. However, it is an actual matter of fact that the current knowledge of the fish immune system seems to lack the key piece to complete the puzzle. In 1953 Nelson described a new role of human red blood cells (RBCs) which would go beyond the simple transport of O2 to the tissues. This new role, involved in the defence against microbes, described the antibody and complement-dependent binding of microbial immune complexes to RBCs. Regardless of the importance of this finding in the field of microbial infection, this phenomenon has been poorly evaluated. Just recently, a set of biological processes relevant to immunity have been described in the RBCs of a diverse group of organisms, which include: pathogen recognition, pathogen binding and clearance and cytokines production. Furthermore, it has been demonstrated that nucleated erythrocytes from fish and avian species develop specific responses to different pathogen associated molecular patterns and produce soluble factors that modulate leukocyte activity. In the light of these pieces of evidences, and in an attempt to improve the knowledge of the immune mechanism(s) responsible for fish protection against viral infections, we raised the question: could nucleated fish erythrocytes be the key mediators of the antiviral responses? To answer this question we decided to focus our project on the evaluation of the crosstalk between red and white blood cells in the scenario of fish viral infections and prophylaxis. For that a working model composed of the rainbow trout and the viral haemorrhagic septicaemia virus (VHSV) was chosen, being the objectives of the project to evaluate: i) the implication trout RBCs (tRBCs) in the clearance of VHSV, and ii) the involvement of tRBCs in the blood transportation of the glycoprotein G of VHSV (GVHSV), the antigen encoded by the DNA vaccine.

Keywords: erythrocytes,virology,vaccines,leukocytes,innate immunity,adaptive immunity,aquaculture
Smart Valve, low cost, low weight and high reliability for tank and cargo compartment inerting systems. (VISTAC)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France
Call: Development of a multi-position valve with associated actuator for cargo fire protection (H2020-CS2-CFP11-2020-01, 2020)
Start date: 2021-02-01
End date: 2023-02-28
Duration (months): 25.0
Total project cost (EUR): 499425.0
EU funding (EUR): 349597.0
Participants: 2
Project status: SIGNED

Valve for Inerting Sytem with Termal ACtuator. The present proposal, called VISTAC, offers cooperation between GDTech, highll skilled company in the field of simulation of thermal, fluid and muliphysics behavior of aeronautical equipment and Equip’Aero TECHNIQUE, recognized design and production organization for aircraft fluid management equipment including innovative solutions. This strong partnership combines expertise in all required fields and experienced practice in working-in and managing research projects. These elements are a guarantee of VISTAC success. A low weight, low cost, high reliability and maintenability optimized multiposition valve will be developped for the needs of future generation of halon free fire extinguishing systems using a common On Board Inert Gas Generation (OBIGGS) with the fuel tank inerting system. State of the art knowledge of the partners in valves technologies will be associated with the development of a new generation of electromechanical actuator using thermal effects. Heat generated by electrical signal is converted into mechanical force and stroke by the mean of Shape Memory Alloys elements or thermostatic wax elements developped in the ATHT project already ongoing in Equip’Aero Technique R&T department. Valve developed will be maturated to TRL6 and will be ready for manufacturing to MRL6. Topic leader and partners may then be able to propose to further certification an optimized fire exitinguishing system with reduced environmental fooprint incorporating a smart multiposition valve. EU industrials and environment shall greatly benefit from this study, thanks to a strong dissemination plan and a wide communication strategy.

Keywords: valve pneumatic inerting fire extinguishing cargo obbigs thermal actuator electrical wax shape memory alloy sma
Sorbent-enhanced Steam Biomass Reforming for Integrated Bio-energy with Carbon Capture and Storage (SE-SBR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

Horizon 2020 of the EU proposed that there is a strong will for Europe to move towards a climate resilient and low-carbon economy, become the leading force in the world in the development of renewable energies, and lead the global fight against climate change. It has been proposed that not only zero emissions, but negative emissions of CO2 are critical since they are the only way to fill the gap between the high CO2 concentration and the desired target. Bio-energy with carbon capture and storage (BECCS) is a promising negative emission technology. However, traditional BECCS technologies have separated bio-energy conversion and carbon capture processes, which will increase the system complexity and energy penalty. Based on the background knowledge and research experience of the Researcher and the Host, we propose a novel BECCS technology, sorbent-enhanced steam biomass reforming (SE-SBR), where bio-energy conversion is integrated with carbon capture. To fulfil this technology, a bifunctional sorbent-catalyst material (BSCM) will be designed and tested and the fundamental component interactions in nanoscale in the material will be explored. The proposal is the integration of the specialty of the Researcher on biomass thermochemical conversion and the specialty of the Host on heterogeneous catalysis and carbon capture materials. Finally, the proposed SE-SBR with BSCMs is expected to replace the conventional biomass conversion methods, ease the fossil fuel energy crisis, and contribute to the low carbon world.
Evolution of the Ape Forelimb: Evidence from Internal Bone Structure (MOSAIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2019-10-29
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Understanding the locomotor behaviour of our Miocene ape ancestors is critical to reconstructing the evolution of walking on two feet, or bipedalism. The Miocene (20-5 million years ago (Ma)) epoch is crucial because it is during this period that the morphological features of living great apes, including humans, were defined. In this respect, Miocene apes show unique morphological combinations that are unlike any living primate, known as "mosaic morphologies", which include derived (ape-like) and primitive (generalised) features more suitable to provide a model from which bipedal fossil humans (hominins) – our direct ancestors – might have evolved. This project uses novel 3D methods (microCT scans and imaging sotfware) to conduct the first holistic analysis of the internal structure of Miocene ape forelimb bones. Bone remodels throughout life in response to load; variation in internal structure thus correlates with forelimb use and offers a more direct window into behaviour than external morphology alone. The bony joints of the forelimb on an array of extant Primate species, including apes and monkeys, will be analysed, shedding new light on Miocene ape locomotion, the evolution of living apes and the emergence of human bipedalism.

Keywords: anatomy,function,miocene apes,evolution,locomotion,microct,hominins,bipedalism
DNA nanohydrogel loaded Liposomal formulations for high loading efficiency of antimicrobial drugs against intracellular bacterial and topical biofilm infections (NANOZID)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-15
End date: 2022-01-16
Duration (months): 24.0
Total project cost (EUR): 214158.72
EU funding (EUR): 214158.72
Participants: 1
Project status: CLOSED

Dr. Sybil Obuobi was awarded her PhD in Pharmacy at the National University of Singapore (Singapore) in July 2018 and is very excited to pursue a postdoctoral fellowship at the University of Tromso The Arctic University of Norway (UiT, Norway) under the supervision of Prof. Natasa Skalko-Basnet, a renowned expert in advanced drug delivery. Their project will exploit DNA nanohydrogels, as a novel universal platform to improve the loading efficiency of antimicrobials in mannosylated liposomes against intracellular and topical biofilm infections. This approach fills the current research gap for high drug loading innovative systems in nanomedicine and holds great promise to improve drug efficacy against difficult-to-reach pathogens thus, there is immense potential for new patentable technologies/products. This area of research will advance knowledge in antimicrobial drug delivery and the outcomes will appeal to formulation scientists, R&D scientists and people with persistent skin infections that impose significant economic challenge and contribute to the spread of antimicrobial resistance. With access to state-of-the-art equipment and interdisciplinary environment within the participating organisations (UiT, University of Helsinki and BIOTEC Pharmacon ASA) and administrative support, Dr. Obuobi will acquire new skills in life sciences, expertise in state-of the art biofilm models, hands-on teaching experience, transferrable skills in grant/patent applications and project management alongside new knowledge in product development. Against the backdrop of her notable achievements as a young scientist, she has the capacity to attain research growth through this fellowship and will seize this opportunity to diversify her competency, improve her record of publications, gain independence, build new international networks and apply for an ERC-StG grant- outputs that are expected benchmarks for academic appointments and essential to launch her career within Norway/Scandinavia.

Keywords: liposomes,dna nanogels,antimicrobials,mannose,bacteria infections
KINDOW – Intelligent Sun-tracking for Vertical Blinds (KINDOW)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2018-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Kindow BV is a spin-off of Delft University of Technology (TUDelft) by bright minds with a passion for sustainable innovation through pragmatic thinking. Sunlight offers the perfect alternative for powering and improving buildings, allowing them to become more energy-efficient and more comfortable to live and work in. The Kindow project enables building managers to save energy and increase comfort by offering intelligent automation for motorized blind systems. It optimizes solar influx with automated positioning of the blinds to save on heating, cooling and lighting. Kindow offers automated integrated solutions that facilitate the transition towards a brighter future with the help of the sun. Kindow seeks to optimize the use of sunlight, in order to create healthy and productive workspaces and improve the energy efficiency of buildings. Kindow optimizes solar influx with automated positioning of the slats of the blinds to save on heating, cooling and artificial lighting resulting in a reduction in energy consumption (up to 25%). Moreover, Kindow provides increased comfort inside the buildings, which leads to increased wellbeing (visual comfort, thermal comfort and access to natural daylight), and a higher productivity (>5% annually). The global smart shade devices market is expected to grow with a CAGR of approximately 90.4% during 2016-2023, reaching €16.7 billion by 2022. Accordingly, we foresee a cumulated profit of 6.1 M€ by 2024 with a ROI of 2.88.

Keywords: intelligent,sun tracking,comfort,vertical blinds,monitoring,automated control of blinds,optimized solar influx