Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Characterisation and impact of kidney-resident Tregs in kidney physiology and pathologies (Kidney-Treg)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-09-29
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Tregs are a subtype of T cells exerting immunosuppressive functions that are vital to prevent autoimmunity. Recently, tissue-resident Tregs have been proposed to be phenotypically and functionally distinct from the generic Tregs in circulation. Systemic Treg supplementation and depletion studies strongly support a role for Tregs in protection from injury and promotion of tissue repair in models of kidney diseases, highlighting the potential of harnessing Tregs in these pathologies. However, due to the systemic nature of the Treg manipulation in these studies, it is unknown if the effect resides in systemic impacts or in tissue-based impacts. The aim of this project is to characterise Tregs located in the kidney and to expand the kidney-resident Treg population, without impacting the systemic population, in order to evaluate their specific impact on the physiology and pathologies of the kidney. First, I will characterise the kidney-resident Tregs using state-of-the-art molecular biology techniques, such as scRNAseq, and an innovative mouse model of cell fate mapping based on a photoactivatable Cre-recombinase. Second, I will evaluate their specific functions in physiology and pathologies of the kidney using a mouse model of tissue-specific Treg expansion uniquely available in the host laboratory. As well as the novel biology exploring the potential functions of kidney-resident Tregs, the distinction between systemic and kidney-based effects is critical to develop new therapeutic tools aiming to target kidney-resident Tregs. The induction of tissue-specific tolerance for kidney autoimmunity or transplantation, without inducing systemic immune suppression, constitute a promising and feasible alternative to existing immunosuppressive therapies. The knowledge and experience gained from this project combined with my scientific and personal development will give me all the skills I need to achieve my objective to pursue an exciting scientific career in academia.

Keywords: tregs,tissue resident t cells,kidney,transplantation,autoimmunity
Natural Product-Inspired Therapies for Leishmaniasis and Chagas Disease (NPsVLCD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The development of new therapies for leishmaniases (which affeThe development of new therapies for visceral leishmaniasis (affects ~12 million people worldwide) and Chagas disease (~6-7 million people worldwide) is critically dependent on the identification of novel pharmacophores with new modes of action. Current treatments suffer from severe side effects, high cost, patient compliance issues, and emerging resistance; as such, new therapeutic leads are urgently required. Despite significant investment, limited progress has been made with research into new 'synthetic' drugs: no candidates are in clinical trials (although two compounds have recently progressed to preclinical evaluation for VL). In contrast, research into natural product-derived drugs has been largely ignored, despite their track record as frontline treatments for VL (amphotericin B) and the most prominent parasitic disease, malaria (artemisinin). In this project, we challenge this dogma through the exploration of a series of structurally-related alkaloid natural product families, where highly promising antiparasitic bioactivity has been observed in the few examples studied. The selection of these families is additionally based on their accessibility through concise, modular and convergent synthetic strategies, which facilitate modification. We couple this central focus of synthetic chemistry with collaborations to evaluate bioactivity (with expert parasitologist Prof Andre Tempone), and identify pharmacokinetic/dynamic limitations (with expert pharmacologist Prof Kevin Read), thereby informing analogue refinement and synthesis. This multidisciplinary approach will greatly enhance the impact of the synthetic chemistry work by providing 'real-time' feedback into compound design, enhancing project efficiency and progress. Our overarching, long term impact objective is to identify a new pharmacophore (and potentially new parasite target / mode of action) for the potential development of VL/CD therapies.

Keywords: leishmaniasis and chagas disease,catalysis
Demonstration and market replication of Innofreight’s innovative rail logistics equipment for the raw material supply of the steel industry (ITECCO Demo)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Austria
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-10-01
End date: 2019-03-31
Duration (months): 30.0
Total project cost (EUR): 3160166.25
EU funding (EUR): 2212116.38
Participants: 3
Project status: CLOSED

The rail-based raw material supply of the European steel industry is currently carried out with outdated special wagons overaged, inflexible and in desperate need for modernization and cost-efficient replacements. Innofreight solves this problem with a modular system consisting of the new ultra-light, multipurpose container waggon, the Innowaggon, and special containers. In the last years the company developed the self unloading RockTainer Ore for the transport of ore and other heavy bulk goods and the MonTainer for the Transport of coal and coke. A newly developed stationary unloading station is used to empty the MonTainers under all weather conditions. The containers are the low cost part of the system. In combination with the InnoWaggon, they build a special waggon, which fits the current needs of the market. Long term changes on the markets can be met by changing the cheap containers. The more expensive part of the system is the InnoWaggon which has alway a high utilisation: equipped with the right containers, it will always fit future demands. A special waggon becomes idle when the demand for its freight decreases. Innofreights system has the following main advantages: Low costs due to high utilisation, low tare weight and higher payload. Additionally it offers safer, faster and more reliable handling processes than conventional solutions. The main goals of this project are: 1. Full scale demonstration of the modular system (waggon, containers and unloading device) in a medium size steel mill. 2. Ready the companies organisational structure and processes to fit a fast growing process by conquering a new market. 3. Dissemination and exploitation of the successful demonstration to convince the stakeholders of potential customers on fairs, in media and in sales conversations. Innofreight already is market leader for the transport of bulk goods for the paper industry. This project aims to become market leader for bulk goods for the steel industry.

Keywords: rail freight transport,steel industry,modular equipment
Wide band gap Innovative SiC for Advanced Power (WInSiC4AP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Research and Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Italy,Germany,Italy,Italy,Italy,Italy,Italy,Italy,Germany,Italy,Italy,Italy,Italy,France,France,France,France,France,France,France,Czechia
Call: ECSEL Key Applications and Essential technologies (RIA) (H2020-ECSEL-2016-1-RIA-two-stage, 2016)
Start date: 2017-06-01
End date: 2021-03-31
Duration (months): 46.0
Total project cost (EUR): 27981714.14
EU funding (EUR): 4121238.19
Participants: 30
Project status: CLOSED

WInSiC4AP core objective is to contribute in developing reliable technology bricks for efficient and cost-effective applications addressing social challenges and market segments where Europe is a recognized global leader as well as automotive, avionics, railway and defence. WInSiC4AP approach is to rely on the strength of vertical integration allowing optimization, technologies fitting application requirements, developing the full ecosystem and approach relevant issues as reliability in the full scope. That enhances the competitiveness of EU- Industries as well as TIER1 and TIER2 down to the value chain in a market context where other countries today, such as the USA or Japan, are advancing and new players accessing SiC enter in the market. New topologies and architecture will be developed for targeted application simulating operational environment, at laboratory level, driving the needed and still missed technologies, components and demonstrators to fill the gap between current state of the art and the very high demanding specifications. WInSiC4AP framework has been built so that companies working in different domains (i.e. automotive car maker and TIER1-2 and avionics, railway and defence TIER1-TIER2) and in the vertical value chain (semiconductor suppliers, companies manufacturing inductors and capacitors) as well as academic entities and laboratories will collaborate to co-design solutions, solve problems and exchange know-how, such that unforeseen results may also emerge. WInSiC4AP will be supported with synergy between ECSEL JU and ESI funding enabling complementary activities with relevant economic and social impact envisage in a less development region of Union.

Keywords: wide band gap material
Life-like Supramolecular Materials based on Reaction Cycles with Designed Feedback (Life-Cycle)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-03-31
Duration (months): 63.0
Total project cost (EUR): 1762488.0
EU funding (EUR): 1762488.0
Participants: 2
Project status: SIGNED

This “Life-Cycle” ERC proposal aims to develop a new class of artificial supramolecular materials that are kept in sustained non-equilibrium states by continuous dissipation of chemical fuels. Supramolecular polymers in current artificial materials stick together through weak reversible bonds that can be exchange by thermal energy. In contrast, natural supramolecular polymers such as those in the cytoskeletal network use chemical fuels such as adenosine triphosphate (ATP) to achieve an incredible adaptivity, motility, growth, and response to external inputs. Development of chemically fueled artificial supramolecular polymers should therefore lead to more life-like materials that could perform functions so far reserved only for living beings. The proposed materials are based on supramolecular reaction cycles that have both positive and negative feedback in order to achieve emergent properties, such as oscillations and waves. Two different approaches are used: i) supramolecular polymers that are fueled by redox reactions, and ii) enzyme-switchable supramolecular polymers that consume one of the natural fuels, namely ATP. The proposed polymers self-assemble cooperatively, which is used as a positive feedback mechanism. Using other co-assembling species we can engineer negative feedback in our reaction cycles to obtain unique supramolecular dynamics. Since the building blocks react, but also self-assemble they have built-in chemomechanical properties, much like in living materials such as the cytoskeleton. First we study the temporal behavior (part A) of our reaction cycles in well-stirred environments. Next, we move to non-stirred conditions (part B), where spatiotemporal behavior can be studied. And lastly, we develop free-standing non-equilibrium interactive materials based on our reaction cycles (part C). Overall, our approach opens a new way to obtain more life-like artificial materials that can eventually perform complex (biological) functions.

Keywords: self assembly,reaction cycle,feedback,supramolecular materials
Multi-Modal Tensor Tomography (MUMOTT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Switzerland,Sweden,Switzerland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1318080.0
Participants: 3
Project status: SIGNED

Capture structures without looking at them directly, but rather by probing their interaction with electromagnetic waves - this is the basic principle for the new multi-modal tensor tomography developed in this research programme. It will enable to study the arrangement of nanostructures in macroscopic samples, six orders of magnitude larger than its building blocks, allowing to apprehend the structure of complex hierarchical materials. I will use visible light observing change in their polarization state as well as the scattering of hard X-rays to probe nanostructure. Both modes capture alignment of nanostructure, while complementary in other aspects e.g. high penetration depth of synchrotron radiation and easy accessibility of laboratory polarimetric setups. At the core of MUMOTT lays the development of the methodological framework implemented in an open-source software package allowing for the reconstruction of tensors in each sub-volume or voxel of the three-dimensional tomogram. Whereas in a first step I will work out a general approach, we will incorporate flexible modules to capture details of the different types of interaction. This approach includes method development pushing the boundaries of traditional synchrotron methods to make full use of the high brilliance and coherence of the new generation of synchrotrons coming online as well as the enabling of studies with lab-based equipment. It opens up for addressing new scientific problems by widening the range of materials as well as the user community. Apart from the methodology framework we will implement the different modes to prove their capability to solve critical problems in materials and bio-science; to investigate the structure of light-weight composites based on cellulose nanofibrils, reveal how the arrangement of nanoparticles in a plasmonic composite is connected to its sensing capabilities, as well as shed light on the disruptive collagen network in liver fibrosis.

Keywords: small angle x ray scattering,computed tomography,soft matter
Perspective of a real-time structural analysis tool assistant based on Computer Vision and Human Intuition (FORSEES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2023-01-12
Duration (months): 36.0
Total project cost (EUR): 251002.56
EU funding (EUR): 251002.56
Participants: 2
Project status: CLOSED

Many of today’s world challenges cover the domain of safety and civil society. In a world like this the need for doctors and diagnosticians of the complex building and infrastructures organisms is imperative and high-priority. The number of variables have exponentially risen and the expert point of view is becoming more and more out of reach. The gap that just some decades ago would have required some years of work experience can be closed nowadays only with the help of new technologies. Artificial Intelligence (AI) is displaying all its power for diagnosing pathologies and diseases in Human Medicine. Imagine to apply the same framework for buildings in order to have the real-time health of the living architectures. Computer science and data analytics are capable of extracting patterns from these data and of producing a knowledge graph of the external reality. The project integrates digital pattern perception with human percepetion models. This models are object of studies for cognitive neurosciences, and by monitoring neurofunctional activity it could be possible to grasp and interpret where a structural intuition resides when a human performs related simple tasks. This structural intuition, in form of a mathematical structure (algorithmic relations), would create an AI tool as structural assistant to see the forces alive by a Computer Vision device. It would represent the growth of a sixth sense for real time structural analyses, building risk perception and architectures performance investigation. The chosen research institutions to carry out in the project are: Structural Engineering Department (DISEG) of Politecnico di Torino, MIT Senseable City Lab and BioRobotic Institute of Scuola Superiore Sant’Anna di Pisa as Secondment. The intelligent structural assistant that represents the research goal will rise up the knowledge to the level of extensive prediction, opening humans to a knowledge based on imaging and exploring more than focus and execution.

Keywords: artificial intelligence,cognitive science,structural engineering
In-vivo Gene Editing by NanotransducErs (I-GENE)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Italy,Poland,Netherlands,United Kingdom
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2019-11-01
End date: 2024-04-30
Duration (months): 54.0
Total project cost (EUR): 2994878.75
EU funding (EUR): 2994878.75
Participants: 6
Project status: SIGNED

CRISPR/Cas9 and enzyme-based editors hold promise for genome surgery by erasing harmful mutations and re-writing in helpful ones, but face critical barriers related to safety. Here, we propose a new concept of genome engineering based on nanotransducers (NT), which aims to make safe previously impracticable applications of genome editing and transcriptional regulation by Cas9. The methodology is based on laser-activation of a NT, which triggers a thermo-switchable double strand DNA break or cleavage. The proposed technology implements a concept of multi-input AND gates, where the output (gene editing) is true if multiple inputs are true (e.g. NT activation and recognition of 2 different loci). Indeed, the dream of unique recognition of the desired genomic target from any potential off-targets in the 3 billion base pairs of human genome would be possible. The superiority of I-GENE technology over current methodologies lies also in the multi-function integration, i.e. integration of the time function (editing only when the laser is on), the spatial function (editing only where the laser is focused) and the fidelity function (editing only if on-target) (when-where-if functions integration). Overall, this enables temporal control of single cell editing and provides an absolute safety level for developing effective genome editing for biotechnology and therapeutic applications. In the present project, proof on concept studies for technology optimization will be performed on non-mammalian zebrafish embryos. Subsequently, the therapeutic potential will be validated in a murine model of melanoma. I-GENE technology would push the boundaries of efficient and reliable ways to make precise, targeted changes to the genome of living cells that is the long-standing and main goal of gene therapy and biomedical researchers.

Keywords: genome editing,nanotransducer
Energy System Transition Through Stakeholder Activation, Education and Skills Development (ENTRUST)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Robust decision making and public engagement
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Ireland,France,United Kingdom,United Kingdom
Call: The human factor in the energy system (H2020-LCE-2014-2, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 36.0
Total project cost (EUR): 3476394.59
EU funding (EUR): 3476394.58
Participants: 8
Project status: CLOSED

ENTRUST provides mapping of Europe’s energy system (key actors & their intersections, technologies, markets, policies, innovations) and an in-depth understanding of how human behaviour around energy is shaped by both technological systems and socio-demographic factors (esp. gender, age and socio-economic status). New understandings of energy-related practices and an intersectional approach to the socio-demographic factors in energy use will be deployed to enhance stakeholder engagement in Europe’s energy transition. The role of gender will be illuminated by intersectional analyses of energy-related behaviour & attitudes towards energy technologies, which will assess how multiple identities and social positions, combine to shape practices. These analyses will be integrated within a transitions management framework which takes account of the complex meshing of human values and identities with technological systems. The third key paradigm informing the research is the concept of energy citizenship, with a key goal of ENTRUST being to enable individuals overcome barriers of gender, age and socio-economic status to become active participants in their own energy transitions. Central to the project will be an in-depth engagement with 5 very different communities across the continent, who will be invited to be co-designers of their own energy transition. The consortium brings a diverse array of expertise to bear in assisting and reflexively monitoring these communities as they work to transform their energy behaviours, generating innovative transition pathways and business models capable of being replicated elsewhere in Europe. Deliverables will include a policy tool-kit incorporating contemporary best practice in promoting energy transitions at a Europe-wide level; a suite of innovative transition pathways and community engagement tools designed to stimulate dialogue and break down barriers to behaviour change and the adoption new technologies at a community level.

Keywords: insectionality,energy citizenship,transition theory,participatory action research