Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
LEISHBLOCK: Exploring an antileishmanial drug toolbox for blocking pathogen transmission in the sand fly vector. (LeishBlock)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia,Switzerland,United Kingdom
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 309768.48
EU funding (EUR): 309768.48
Participants: 3
Project status: SIGNED

The main objective of LEISHBLOCK is identifying antileishmanial compounds exhibiting minimal mortality to sand flies for exploitation as potential transmission blocking agents. Sand flies are the vectors responsible for transmitting Leishmania parasites, the causative agents of a range of disfiguring to lethal diseases known as leishmaniasis, affecting populations worldwide. Currently, with no human vaccines, disease control relies on reducing contact with the vector and chemotherapy. However, the effectiveness of leishmaniasis-vector control, which includes non-specific insecticide spraying, insecticide-impregnated nets, and environmental management, lags behind other disease-vector-control approaches. Moreover, treatment options for leishmaniasis are limited and often require prolonged hospitalization. To address this pressing public health issue, there is an urgent need to harness existing knowledge on the biology of these parasites, utilize available resources, and explore novel approaches to disease control. Recently, a promising transmission blocking intervention (TBI) has been pursued for vector-borne diseases like malaria, focusing on targeting parasites within the insect vector with a parasiticide. This innovative approach has demonstrated the potential to become a valuable addition to the arsenal of TBIs and merits attention in the field of leishmaniasis. Compounds will be firstly screened using sand fly and bee cell lines. Then, the safest compounds will be individually tested on the respective adult insects. The leading compounds demonstrating greater safety will be assessed for their efficacy in reducing parasite burden in Leishmania-infected sand flies, employing an innovative DNA barcoding approach. The knowledge gained from this multidisciplinary project will contribute to the discovery of urgently needed new drugs to combat this neglected and important emerging vector borne disease, while building on the research profile of the leading investigator.

Keywords: transmission blocking,drug discovery,leishmania,barcoding,sand flies
Examining the Evolving Steering Role of NGOs on the case law of the Inter-American Court of Human Rights (NGOsteerIACtHR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: SIGNED

Through litigation strategies and third-party interventions, non-governmental (NGOs) set the normative agenda of, and thereby constantly (re)shape, the Inter-American Court of Human Rights (IACtHR). Yet most studies on the evolving jurisprudence of the Inter-American Human Rights System (IAS) relating to environmental matters primarily centre on the interpretative innovations made by its judiciary. NGOsteerIACtHR develops and applies an analytically and empirically grounded framework to examine the influence of NGOs’ agenda-setting power on the IACtHR’s case law, in which environmental protection serves the interests of human rights. Whilst generating up-to-data knowledge on the role of NGOs within the IAS, this projects differs from the state-of-the-art by illustrating to what extent the evolving human rights and environment agenda of NGOs is behind the evolving IACtHR’s jurisprudence on the subject. To this end, it will combine doctrinal and content analysis of selected contentious cases (involving indigenous groups, environmental defenders and the right to a healthy environment) and the Advisory Opinion No. 23 on Human Rights and the Environment. As children are now getting involved in litigation before the IAS (Soleil v Haiti), NGOsteerIACtHR will provide a better understanding of how and to what extent the human rights and environmental agenda can be incorporated throughout the written and oral phases of contentious cases. Besides, considering that the IACtHR may employ its advisory proceedings to influence state behaviour and address questions that are likely to arise before its contentious jurisdiction, it will offer clear insights into the role (implicitly) played by NGOs in shaping the normative countours of the Advisory Opinion No. 23 and state conduct alike.

Keywords: ngos inter american court of human rights human rights inter american human rights system indigenous people environmental defenders right to a healthy environment
Maps And Graphs In Mind And Brain (MAGIMAB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-01
End date: 2025-01-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

How do our mind and brain represent the world? In this project, I propose that cognitive maps and cognitive graphs are two fundamental representational formats supporting our physical (space and time), conceptual (taxonomic and thematic knowledge), and cultural (individualism and collectivism) cognition. To test this hypothesis, I will combine state-of-art neuroimaging techniques with innovative cognitive tasks, including virtual reality, to disentangle cognitive maps and cognitive graphs in both physical and conceptual domains. I will also develop questionnaires and implicit behavioral tasks to assess individual preferences for map and graph representations and test whether this preference relates to the individual difference in cognition and culture. This project has the potential to help trigger a paradigm shift from the traditional map perspective to a dualistic perspective, which focuses on both maps and graphs, thereby deepening our understanding of the organizing principles underlying cognition across domains. This perspective could also inspire the current development of artificial intelligence, and the characterization of individual differences in this project could, in the long run, guide policymaking, design, and education. This project will be hosted by the Max Planck Institute for Human Cognition and Brain Sciences, which owns the most advanced neuroimaging facilities and a powerful network of servers for data storage and analysis. Prof. Christian Doeller, who is among the top cognitive neuroscientists in spatial memory and knowledge representation, will be the supervisor. This project will also open a new career avenue for the applicant by providing valuable opportunities to develop scientific and technical skills.

Keywords: cognitive map cognitive graph mental representation neural coding spatial and temporal cognition taxonomic and thematic knowledge individualism and collectivism
Gravitational Physics from the Universe Large Scales Evolution (GraviPULSE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1999219.0
EU funding (EUR): 1999219.0
Participants: 1
Project status: SIGNED

How does gravity work on cosmological scales? Starting from July 2023, for the very first time in the history of space science, the geometry of the Universe Large Scales will be mapped by the Euclid mission, providing the scientific community with a wealth of cosmological data of unprecedented quantity and quality. It will be a transformational moment that will open a new ground for testing gravity; yet, unless combined with a theoretical framework able to translate wonderful numbers into concepts, this is bounded to be a missed opportunity. This research program - whose proponent is currently serving in the role of co-Lead of Euclid Theory Working Group - aims at constructing such a framework. Euclid will compare the action of gravity on light with that on non-relativistic particles, in a regime vastly different from where General Relativity has been confirmed. Any significant detection of a deviation, will have profound consequences. But how to confidently dissect and decipher these potential signals? In the past years I have laid the ground work for cosmological tests of gravity, culminating recently in a first reconstruction of gravity from available data. These results are at their infancy and a leap beyond the current state of the art is urgently required to breach into the smaller, nonlinear scales where statistical errors will be at their lowest. The timing could not be better, with data releases of Euclid expected during the tenure of this proposal. From an exhaustive exploration of the gravitational landscape under criteria of theoretical viability, we will create predictions of the Large Scales phenomenology by broad classes of theories, with an accuracy that meets Euclid requirements. These will be used to construct a comprehensive phenomenological framework extending into the nonlinear regime and inform bayesian non-parametric reconstructions of gravity from the latest data. As a result, we will provide a completely new view into gravity on Large Scales

Keywords: gravity,tests of gravity,modified gravity
Simultaneous Trace Gas Detection Platform (MULTI TRACE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-09-01
End date: 2027-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

In response to the European Council's revision of air quality directives in October 2024, there is an urgent need to improve monitoring of global pollution gas concentrations and develop effective air quality management strategies. Current monitoring systems operate on a coarse grid with limited sensors that only target specific trace gases, leading to the omission of critical pollutants like ammonia. This results in costly, complex, and inefficient monitoring. MULTI TRACE introduces the world's first field-deployed dual comb spectrometer platform, enabling real-time tracking of three vital trace gases including nitrogen dioxide and ozone. This innovative technology is unique in Europe for its capability to monitor multiple gasses simultaneously with high temporal resolution on the second scale. Trace gases are often interconnected through solar-induced reactions, complicating accurate concentration measurement; however, MULTI TRACE operates in a spectral range where strong absorption signatures for all gases under scrutiny are present. Field investigations will showcase the platform's capacity to monitor gas concentration fluctuations in varied urban and forested settings, confirming its versatility, innovation, and reliability. Collaborating with a leading laser company and engaging with stakeholders from different environmental sectors in Austria, we aim to create a prototype that surpasses current commercial devices in detection limits and temporal resolution. MULTI TRACE has the potential to transform gas monitoring applications not only for environmental sensing but also across industries like oil and gas, chemical manufacturing, and emergency services. Portable gas detectors are essential for safety, helping to identify leaks and monitor volatile organic compounds. As regulatory frameworks tighten and workplace safety awareness increases, the global market is projected to grow from an estimated $5.07 billion in 2024 to $8.81 billion by 2034, displaying an annual growth rate of 5.69%.
Probing the role of mechanosensory pathways in regulating intestinal stem cell activity and gut homeostasis (MECHANOGUT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

In adult organisms, gut barrier function is maintained by adapting the proliferation and turnover of resident intestinal stem cells (ISCs) to environmental cues. In recent years, an immense effort in the field has successfully identified many short and long-range signals involved in ISC-driven adaptive growth responses. However, it is becoming increasingly evident that biomechanical cues, such as shear stress, compressions, swellings, and tissue-scale tension, also play a key role in regulating SC activity in adult tissues. Hence, the adult gut is constantly exposed to mechanical stress and must adapt accordingly to the stretch and strain. Despite the undisputed impact that mechanical forces have on adult organ physiology, very little is known about the molecular signals involved. Using Drosophila as a model, we performed a genetic screen for ISC niche receptors coupling environmental cues with ISC-dependent adaptive growth and identified several receptors belonging to mechanotransduction pathways as indispensable for preserving gut barrier function. Mechanical forces can be either of tissue intrinsic origin, such as forces emanating from cell division and cell death, or of external origins, such as those originating from extracellular matrix remodeling, mechanical coupling to neighboring tissues, and food and fluid flow. Recent studies in developing embryos and during tissue morphogenesis show that cells can sense mechanical forces through mechanotransducer proteins, and are used as cues to regulate gene expression patterns, cell fate specifications, cell packing, and proliferation. An insight into mechanosensation in regulating ISC niche homeostasis in mature organs is still lacking and given my scientific background in biophysics and mechanobiology, this study aims to understand the role of mechanosensory inputs in maintaining the ISC niche using the Drosophila adult gut as a model system.

Keywords: intestinal stem cells,mechanobiology,cell proliferation,cell fate,gene expression patterns
Game Changing Deep-Tech removing barrier to farmed salmon production growth for climate- & planet-friendly low carbon footprint animal protein (Game Changer)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Ireland
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-06-01
End date: 2023-05-31
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Globally the salmon aquaculture industry is worth circa $14 billion USD (2019 figures), the main obstacle to further growth is the tiny sea louse. Konree Innovation is developing a deep-tech game-changing and disruptive technology to tackle this, the single most feared and persistent, pest in salmon aquaculture – the sea louse. The sea louse is regulated everywhere it is farmed, once the levels present reach the regulatory threshold, it triggers treatment. The direct cost to the industry in treatments for sea lice is approximately $1 billion USD (2019 figures), while the indirect cost is estimated to be ca. $3 billion USD, mainly due to fish deaths brought about by weakening of the salmon due to sea lice induced wound infections and bacterial diseases therein as well as the non-optimised handling of the fish during treatments. Up to 20% of production can be lost in this way. Konree Innovation is developing a deep-tech non-fish-handling solution that will employ both artificial and machine learning to outsmart the sea louse’s biological strategy for infestation. The sea is a tough harsh environment, the technology will need to perform well in this environment and do no harm to the fish in the pen, the pen itself or the environment. All these requirements demand a deep-tech solution. Konree Innovation is internationally focused: Norway has 56% of global production, next Chile at 28%, North America at 7%, Scotland at 6%, Australia and New Zealand at 2.4%, Ireland at 0.6%. Iceland and the Faroe Islands are now also farming Atlantic salmon. Consumer demand for alternative climate- and planet-friendly sources of protein is expected to get much higher, and farmed salmon offers a highly nutritious source of animal protein with a low carbon footprint. An effective way to maintain control and manage sea lice numbers will overcome the barrier to growth and enable the salmon producer industry to compete with the big meat producers that have a much higher carbon footprint.

Keywords: sustainability,deep tech,salmon,sea louse,lice,game changing,disruptive,low carbon production
Gating cell force sensors with tailor-made nanoswitches to restore tendon tissue function (FORTIFy)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Portugal
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1999186.0
EU funding (EUR): 1999186.0
Participants: 1
Project status: SIGNED

It’s becoming increasingly clear that a deeper understanding of tendon mechanobiology is required for the development of effective therapies for tendon injuries and diseases. The involvement of specialized cell force sensors, such as PIEZO channels, on the mechanosensory processes through which tendons sense and adapt to mechanical loading have just started to be unveiled. Decoding the underlying mechanisms governing these processes would promote the development of innovative therapies to restore tendon function. However, a remaining barrier to unlock the therapeutic potential of PIEZOs is how to effectively target and gate these complex mechanoreceptors in different tendon cell populations (both in vitro and in vivo) and what are the actual biological feedbacks of its activation. FORTFy ground-breaking concept will merge molecularly imprinting technologies and magnetic systems to establish a versatile wireless platform of tailor-made abiotic nanoswitches for the programmed manipulation of PIEZO receptors. Combined with a new generation of advanced tools, including humanized 3D microphysiological systems enabling to study the multicellular crosstalk occurring in tendon microenvironments and to obtain improved bioengineered tendon grafts, it will enable to explore the full potential of PIEZOs as targets for treatment of tendinopathy. The challenging ambition of FORTFy will be accomplished by implementing a thorough in silico, in vitro and in vivo research plan aimed at probing the role of PIEZO-mediated mechanosignaling on tendon homeostasis, degeneration and aging, focusing the neurotendinous crosstalk and its immunomodulatory signatures. The success of FORTFy will not only lead to unprecedented nanomedicine tools for treatment of tendinopathy, but its fundamental concepts will certainly impact the therapeutic options of a wide range of other PIEZO-regulated diseases related with musculoskeletal dysfunctions, immunological responses and proprioception.
Empirical Constitutional Law: A New Theoretical and Methodological Approach (EmpiriCon)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Constitutional law worldwide suffers from an empirical deficit: although evidence is needed to apply the law to concrete conflicts, constitutional analysis is dominated by high-level value judgments and pays little attention to empirical evidence. Unlike other fields of law, there are almost no empirical studies regarding constitutional controversies, and most courts, legislatures, and executives have no adequate procedures for establishing facts or reviewing evidence in constitutional matters. The empirical deficit of constitutional law has detrimental consequences. It generates unpersuasive decisions; brings about inadvertent societal consequences; breeds accusations that constitutional decisions are subjective and biased; and lets unvalidated facts influence decisions in the absence of proper procedural safeguards. EmpiriCon will develop a new approach that offers to rejuvenate constitutional law as an evidence-based field of law. Based on a comprehensive theoretical analysis of the empirical gaps in constitutional law (WP1), six multi-method empirical studies of key constitutional gaps (WP2), and eight survey experiments that examine the implications of rigorous fact-finding for public trust in constitutional decision making (WP3), I will develop a new theoretical and methodological approach (WP4), showing that empirical constitutional law is not only theoretically justified, but also methodologically feasible and concretely valuable. This approach will ground constitutional reasoning in transparent methodology, improve the quality of constitutional decisions, and may even increase public trust. Simultaneously, the shift to empiricism involves risks, such as data manipulation, and has inherent limitations. I will incorporate the limitations, map out the risks, and propose ways to tackle them. If successful, the project will transform constitutional law, with far reaching implications for scholars, legislatures, executives, courts, and litigants.

Keywords: empirical legal studies,constitutional law