Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MicroRobotic toolkit to deliver spatiotemporally resolved physicochemical signals and control cell sociology (ROBOCHIP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2022-08-31
Duration (months): 66.0
Total project cost (EUR): 1748773.0
EU funding (EUR): 1748773.0
Participants: 1
Project status: CLOSED

Biological organisms have spectacular three-dimensional morphologies in which correct multiscale organization and physicochemical regulation are essential for proper function. Understanding the dynamic interactions among cells connected through a structurally complex three-dimensional (3D) fibre network requires a rigorous system identification effort and engineering analysis. To develop accurate and comprehensive models of cell sociology, we need to identify how several different components act together as a connected system and define high-order emergent programs that constitute layers of signals in time and space. The objective of this proposal is to engineer new microrobotic technologies that can be seamlessly integrated with high-throughput bioengineering platforms and produce physiologically relevant signals to establish an active dialogue with the members of the tissue community and drive the cell-network evolution. We propose to build cutting-edge robotic micromanipulation systems to perform automated operations on 3D biological samples with exceptional dexterity and high spatiotemporal resolution. Wirelessly powered micromachines will modulate local mechanochemical signaling within the tissues and move through fibrillar scaffolds. Multi-functional integrated platforms will simultaneously apply external and internal signals, and advanced imaging systems will visualise whole tissue activity at the cellular resolution. Our data will be used to establish computational models of tissue-level mechanical response to dynamical perturbations with particular focus on transmission of signals and feedback mechanisms. The ability to hack cellular communication links and interfere with the biological processes in 3D systems will lead to a better understanding of morphogenesis and regeneration, and can aid in developing treatments that ensures a microenvironment with a distribution of signals that minimizes disease progression.
Dissecting the impact of Lactate in Tuberculosis (Lac-TB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-23
End date: 2024-03-24
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

Tuberculosis (TB) is a major global public health problem in which one-fourth of the world’s population is latently infected. Host-directed therapeutics are a promising approach; however, we require a comprehensive understanding of how host-pathogen interactions impact signalling pathways and cellular responses to dictate disease outcome. Metabolic reprogramming of immune cells has been described during Mycobacterium tuberculosis (M.tb) infection, resulting in active glycolysis and lactate production. Lactate is an active signalling molecule and macrophages, the main M.tb cell target, can respond to it through different transporters. The main aim of this project is to investigate the crosstalk between metabolic and immune responses in the context of M.tb infection, with a particular focus on macrophage responses to lactate. This project has the potential of revealing new host immune-metabolic therapeutic targets for TB disease. Birmingham has one of the highest rates of TB in the UK and University of Birmingham (UoB) is a world-reference institution for metabolic and metabolomic studies. Dr Llibre has a strong background in immunology and moving to Dr Mauro’s laboratory at UoB will provide her with a rare opportunity to obtain a unique skillset, allowing her to study cell metabolism in high resolution. The expertise, facilities and supervisory team at the host institution, together with Dr Llibre’s extensive knowledge on immunology and infectious disease ensure the feasibility of this project. UoB will provide Dr Llibre a privileged environment to fully develop all the skills required to lead a successful research group, including training in scientific communication; opportunities for supervising and teaching, for learning how to coordinate a project and protect intellectual property. At the end of the fellowship, Dr Llibre will be at the forefront of the much needed and exciting field of immuno-metabolism, equipped to secure funding as an independent researcher.

Keywords: immunometabolism,macrophage,tuberculosis,lactate,lactate transporters
A software framework for the efficient setup of industrial inspection robots (SPIRIT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Italy,Austria,Austria,Italy,Italy,Germany,Italy,Austria
Call: Advanced robot capabilities research and take-up (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2021-05-31
Duration (months): 41.0
Total project cost (EUR): 3732751.25
EU funding (EUR): 3145640.0
Participants: 9
Project status: CLOSED

SPIRIT aims to develop an "inspection skill" for robots that takes the step from programming of complex inspection tasks to configuring such tasks. For system integrators this will reduce engineering costs and effort for deployment of inspection robots by 80%. Results include an "offline framework" with features such as model-based automatic coverage planning for complex parts, automatic robot program generation and an "inline framework" that deals with sensor data mapping to transfer 2D measurements to the 3D object model. At the heart of the project is an accurate process-specific model that represents the sensor data acquisition process with sufficient accuracy to allow automatic planning. The "offline framework" will include a generic interface to allow the easy exchange of process models (for different inspection technologies), of the CAD model of the part (for a different type of product to be inspected) or of the work-cell model (for a different kinematic structure). The generic "inline framework" will provide the backbone for the execution of the actual inspection process. Relying on such a proven frameworks will reduce the risks of implementing complex inspection tasks and thus help the deployment of inspection robots. The three end-users from the automotive and aerospace industry as well as the technology providers and system integrators in the project all have experience with the above mentioned technological issues and estimate that a potential of 600 to 1000 additional robotic installations can be realized per year. The generic frameworks will particularly enable SMEs to address a larger market beyond their regional focus by reduce the risk of setting up inspection robots, Considering the exploitation potential the SPIRIT project will achieve a suitable return on investment for the project partners within about 2 years.

Keywords: inspection,coverage planning,image stitching
RESEARCH INFRASTRUCTURES FLAGSHIP CONFERENCE Enhancing Long Term Sustainability and Opening Up RIs to Society and Industry (OpenRIs)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Action type: Coordination and support actions
Countries involved: Bulgaria
Call: Conference on the opening up of research infrastructures to new regions in the context of their long-term sustainability (H2020-IBA-INFRA-SUSTAINABILTY-2017, 2017)
Start date: 2017-11-01
End date: 2018-08-31
Duration (months): 10.0
Total project cost (EUR): 125000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Research infrastructures (RIs) are one of the key elements for the development and improvement of knowledge and technology. Long term sustainability has been repeatedly highlighted as the main challenge for European RIs and it will depend on a common understanding and agreement among policy-makers and research managers as well as the industry stakeholders. Building and enhancing scientific excellence is the main prerequisite for long-term sustainability but often governments and industry apply additional requisites for further and future investments in infrastructure such as socio-economic impact, opening up to innovations and markets, attracting private investments and equipping next generation with appropriate and high-qualified skills. Crucial part of the debate on the long-term sustainability of RIs in Europe is the management and enhancement of e-infrastructures, data access and use, and the links to the European Open Science Cloud. Secondly, the development of the ERICs (European RIs consortiums) and engaging governments and national funding agencies in supporting, coordinating and participating actively in them. Last but not least, in the overall discussions for the future of Europe, achieving the European Research Area and the next Framework Programme 9th, is emerging the question on the inclusiveness in ERA and active involvement of the RIs from the periphery of the European continent for increased mobility, networking and competitiveness of all European regions. In the prospect of the discussions on the proposal of the European Commission on the next Multiannual financial framework and the 9th Framework Program for Research and Innovation, coupled with exploring the opportunities for promoting public-private partnership, the project for a Flagship conference during the Bulgarian EU Presidency intends to provide a platform for discussions on increasing the impact of research and innovation for society and industry.

Keywords: research,innovation,excellence,research infrastructures,long term sustainability,impact,ecosystem,human resources
Development and scale-up of cognitive detection and stimulation platform for dyslexia by using automatic learning and scientific validations in educational environments (Change Dyslexia)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Change Dyslexia is a social company based in Barcelona that gives a solution to a large-scale problem offering at the same time a response to market needs. Dyslexia affects about 10% of the population and it is related to high rates of school failure and excluded population, affects reading and writing but it does not affect general intelligence so people with dyslexia can learn coping strategies to deal with its negative effects. However, most frequently dyslexia is detected too late for effective intervention. Change Dyslexia transform this situation by including and empowering children using scientifically based applications (protected by a files patent) mix of artificial intelligence, computer games, linguistic studies and data analysis, that screen and treat dyslexia at large scale with 90% accuracy (higher that other methods that are even longer and more expensive). As the competitors are especially strong for English market, Change Dyslexia first focus in the Spanish-speaking market that is less served and where the opportunity of social impact is higher. Compared to main competitors, this product is scientifically based, social, and the most complete to overcome dyslexia. The social impact of Change Dyslexia is global and measurable. Worldwide, 100,000 children in 43 different countries had a free pre-diagnosis of dyslexia in only one year. Also, during 2017, 250 families benefited from a treatment scholarship provided by Change Dyslexia. By 2020 it is expected to have reached 500,000 children with the screener, provided 20,000 scholarships to families, and proven a decrease in the school dropout rate (Change Dyslexia is currently working with the Education Council of Madrid on a longitudinal evaluation with 100 schools). This way Change Dyslexia will become a reference for scientific and digital solutions for dyslexia.

Keywords: dyslexia,machine learning model
Trusted, traceable and transparent ontological knowledge on blockchain (OntoChain)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Ireland,Italy,Greece,Slovenia,Greece,France,United Kingdom,Luxembourg
Call: Blockchain for the Next Generation Internet (H2020-ICT-2020-1, 2020)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 6011100.0
EU funding (EUR): 6011100.0
Participants: 9
Project status: SIGNED

During the last years we are witnessing an ever increasing number of Internet-based marketplaces that capitalize on the unused capacity of assets they already possess, while consumers can receive services from their peers owning assets either for free or at a lower cost. At the same time, the emergence of cryptocurrencies and smart contracts have enabled new distributed application ecosystems, e.g., Ethereum, Hyperledger Fabric, Stellar, Waves, etc., where new services can be deployed with low-entry market barriers, due to minimal infrastructure costs and decentralized and secure transaction management. Innovative business models arise where part of the value generated by these distributed apps is fed back to the distributed blockchain community, as remuneration for their contribution of computational resources. Companies and organizations still require trust: they need to understand their user base, verify identity, manage digital assets, and control trust issuance within their ecosystem. To maximize the market impact of this new economic environment, OntoChain aims to enable trustworthy transactions of services and content. OntoChain will define innovative decentralized reputation models that reveal hidden quality and/or type of providers/services, or credibility of data sources, while adequately balancing the trade-off between privacy and trust. OntoChain will enable trustworthy and traceable content handling where authorized parties can process data according to the privacy policies of the data owners. At the same time, it will build an economically sustainable ecosystem, where the total value generated in the system, in terms of profit or well-being, surpasses the total operational costs in terms of electricity consumption. In order to sustain the user community, OntoChain will aim on fair sharing of the generated value among resource contributors and provide appropriate incentives to the user community for participation.

Keywords: distributed ledger technologies,semantics,reputation models
Chemistry Meets Quantum Sensing: Towards Atomic Architectures Tailored for Diamond Probes (ChemiQS)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Czechia
Call: Widening Fellowships (H2020-WF-03-2020, 2020)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 144980.64
EU funding (EUR): 144980.64
Participants: 1
Project status: SIGNED

Quantum sensing is a recent, dynamically expanding field affecting many scientific and industrial disciplines, including chemistry, biochemistry, biology and medicine. I have been advancing this field by developing quantum physical principles for the detection of Nitrogen‑Vacancy (NV) spin states in diamond. In my recent collaboration with the hosting supervisor, we have demonstrated that nanodiamond particles (NDs) can act as an optical probe for redox reactions reaching unprecedented sensitivity of 10 external spins. ND probes have enormous potential for instance for intracellular localized detection, but the sensitivity is limited by short NV coherence times due to subsurface defects and unsaturated bonds. Moreover, the sensor specificity and colloidal stability in the biological liquids need to be addressed. I aim to tackle these drawbacks by developing a radically novel chemical approach to remove the unpaired electrons and by engineering ultrathin polymer coatings and linking strategies. To reach the project's complex goals, a highly interdisciplinary approach is proposed. My plan is to 1) annihilate the dangling bonds and subsurface defects by controlled surface removal using radical etching in the gas phase, 2) develop colloidally stable ND probes using ultrathin polymer coating, 3) use NV spin properties to optically detect paramagnetic ions and nucleic acids in biologically relevant conditions with unprecedented sensitivity. The proposed fellowship will allow me to look at the problematics of quantum sensors from the chemical point of view, complementing my expertise in physics. Furthermore, acquiring chemical skills by working in a leading ND surface chemistry group, will improve my prospects to become a leader in the topic of quantum biological sensing, which I want to pursue further in my home country. At the same time, I would like to bring to the host group my expertise in quantum sensing methodology that will be used in the project and beyond it.

Keywords: nanodiamond,quantum sensing,nitrogen vacancy centers,polymer interface,relaxometry
Adjudicating Islamic Family Law in Egypt: Continuity and Rupture (Islamic Law Egypt)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-15
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

The overall aim of this fellowship is to provide opportunity for an early career researcher to carry out a research project dealing with adjudication of family law in Muslim courts of law. The project focuses on the case of Egypt, a Muslim majority country with a hybrid legal system combining civil and Islamic law. Relying on ethnographic fieldwork, the project investigates adjudication of Muslim family law by five Cairenese family courts during the period 2011-2015, a critical juncture in modern Egyptian history. The project aims to accomplish the following three objectives: (1) The project aims to contribute to the scholarly literature on law in action and context, more specifically a growing literature on the implementation of shari‘a-derived family legislations in courts. (2) Given that Muslim family law is ostensibly drawn from the stipulations of Islamic shari‘a, a further aim is to shed light on the intersection between law and Islamic normativity in this field of law, and how legal reasoning is shaped by a modern, positivistic conception of law. With the intention of developing novel concepts on the role of courts in developing the law, it combines an in-depth study of shari‘a in practice in Egypt with a comparative perspective on adjudication of family law in other Muslim jurisdictions. 3) To foster career development through publications, research training, and public outreach. The project explores how male and female judges on Cairenese family courts construct idealized notions of family, marriage, and gender relations by drawing upon sources as diverse as legislation, precedent, custom, Quran, hadiths, uncodified fiqh, and international conventions in a way that is sensitive to context. The project crosses draw upon different disciplines. However, the primary aim of the project is to address legal-sociological theory and debate. The project involves transfer of knowledge to the host institution as well as the experienced researcher.

Keywords: sociology of law,family law,post revolutionary egypt,islamic shari a,gender,law and society,legal pluralism
Development of an artificial alkane monooxygenase: A leap in bioinspired oxidation catalysis (TAML-ArM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

The oxygenation of inert C-H bonds is a highly challenging reaction that has an enormous untapped potential for the European chemical industry. Indeed, it offers attractive means to upgrade cheap hydrocarbons into high value-added products. Nature relies on iron-based enzymes and oxygen to perform such transformations. In a biomimetic spirit, catalytic alkane hydroxylation is best achieved using iron-based catalysts and H2O2 as oxidant. Compared to natural enzymes, however, such systems display modest performance. In the TAML-ArM project, we aim to the development of a novel approach that consists of creating an artificial alkane monooxygenase by introducing a highly active iron complex within a protein scaffold. This strategy, pioneered in the Ward group, has ample precedent for less challenging reactions, and it potentially represents a significant step forward in bioinspired hydroxylation chemistry. To achieve this goal artificial metalloenzymes merge homogeneous- and enzymatic catalysis, two traditionally complementary strategies. We envision that this approach will: i) improve the catalytic activity by protecting the highly reactive Fe=O-moiety by shielding it from undesirable side-reactions and ii) provide novel selectivities, owing to second coordination sphere interactions between the protein and the substrate. Thanks to this innovative catalytic approach, we will develop a paradigm shifting technology for the selective hydroxylation of hydrocarbons: the reactions will be performed in water at room temperature using benign H2O2 as oxidant.

Keywords: artificial metalloenzymes,bioinspired,alkane hydroxylation,iron,high throughput screening,green chemistry