Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A real-time, online study of the functions of consciousness (Consciousness online)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Israel
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 182509.2
EU funding (EUR): 182509.2
Participants: 1
Project status: CLOSED

What – if any – is the functional significance of conscious awareness? Even after centuries of theoretical effort and decades of experimental research the answer to this question is still unknown, partly due to conceptual and methodological limitations of previous approaches. Here, I propose a novel approach that addresses this fundamental psychological question by capitalizing on neuroscientific development. Namely, I plan to construct a real-time system that analyses intracranial and EEG data and presents it to the subject as sensory feedback. The system will be trained to detect unconscious neural events as they unfold, and present them to the subject online, hereby turning these unconscious events into consciously accessible ones. The effect of this manipulation on performance can then be measured, revealing the unique contribution of consciousness to the function of interest. This proposal includes four experiments that will focus on consciousness’ involvement in volitional control, using the Binocular Rivalry paradigm (BR). In BR, subjects' perception alternates between two stimuli presented simultaneously but separately to each eye. Previous studies showed that subjects can control these alternations, but to a limited extent; unconscious processes (e.g., stimuli habituation) lead to perceptual alternations at unpredictable times. Here, I plan to ask subjects to try and exert such volitional control over rivalry while being presented with real-time sensory feedback about the unconscious processes that lead to upcoming alternations. I predict that such feedback about the otherwise unconscious neural activity will enhance subjects' ability to control the rivalry. This promises to yield new insights about the widely debated role of consciousness in volitional control while paving the way to a systematic, innovative investigation of the possible functions of consciousness.

Keywords: consciousness,functions of consciousness,binocular rivalry,intrcranial recordings,real time analysis
Innovative Welding Processes for New Rail Infrastructures (WRIST)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Sweden,Belgium,Belgium,France,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Smarter design, construction and maintenance (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-05-01
End date: 2019-01-31
Duration (months): 45.0
Total project cost (EUR): 4188356.25
EU funding (EUR): 4188355.75
Participants: 12
Project status: CLOSED

WRIST will develop and demonstrate flexible and cost effective joining processes for rail products, and in particular for advanced bainitic rail steels, which have been developed to answer the increasing demands of increasing speed and growth of railway’s load. This will be delivered by the combined development of the joining processes itself, welding experiments, computational modelling, material and joint characterisation and testing, using laboratory tests and full-scale field testing in industrial or commercial test tracks. The project will offer a step change in the joint performance and reliability providing an extended in-service life for a range of rail materials, therefore resulting in a significant cost reduction in maintenance of the track, also freeing up more capacity for rail traffic. New variants of the aluminothermic and orbital friction welding processes will be developed, which will both reduce the width of the heat affected zone and minimise the loss of mechanical properties in the weld zone. These innovations will enable the use of bainitic rail steels which will deliver an increased reliability, a longer lifetime of the rails and welds combined with a reduction of the maintenance cost. The project addresses the specific call topics by: - Development and application of advanced joining technologies, able to join conventional and bainitic rail steels with a higher quality and reliability, to meet the more stringent infrastructure requirements imposed by increased speed and load, resulting in less maintenance and a longer track lifetime. - Reduction of maintenance cost and life cycle cost of the rail and welds, due to less repair welding associated with a higher weld quality and the longer track lifetime. - Increased availability of the track; less unforeseen maintenance. - Profit for users: less disruptions and a higher safety level. - Use of a more environmental friendly and energy efficient joining techniques.

Keywords: welding,bainitic rail steels,maintenance cost reduction
Retinal Imaging prevention and early detection of chronic diseases (RETINAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2016-04-01
End date: 2016-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

"The World Health Organization (WHO) in its “Global status report on noncommunicable diseases 2014” shows that the impact of noncommunicable diseases (NCDs), also known as chronic diseases, is steadily growing. NCDs are the leading cause of death globally (68% of all deaths in 2012). The 4 main types of NCDs are cardiovascular (CVD) diseases (like cerebrovascular accidents or strokes and heart attacks), cancers, chronic respiratory diseases and diabetes. Cardiovascular diseases account for most NCD deaths (17.5 million people annually), followed by cancers (8.2 million), respiratory diseases (4 million), and diabetes (1.5 million). This proposal addresses the prevention and early diagnosis of 2 types of NCDs, Cardiovascular (CVD) diseases and diabetes, by providing health professionals a tool for automatic quantification of parameters of the retina and automatic detection of lesions of the retina, with capacity for prevention and/or early detection of various diseases. ULMA Embedded Solutions (UES) has developed a non-invasive and cost-effective tool for Automatic evaluation of Retinal Imaging Biomarkers (ARIB), which can be used in public health interventions delivered through a primary health-care approach to strengthen early detection and timely treatment of various diseases. Evidence shows that such interventions are excellent economic investments because, if applied to patients early, can reduce the need for more expensive treatment. "

Keywords: imaging,chronic deseases
Feasibility Study for HUTI – the Human Traffic Assistance System (HUTI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Lithuania
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-07-01
End date: 2016-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Currently passenger flow in airports is managed through a combination of advanced IT software solutions (data analysis, passenger flow analysis) and the use of physical barriers (wall-mounted retractable belts, post and panel barricades, swing gates, or portable stanchions). The deployment and management of physical barriers is a costly and time-consuming procedure that is slow to react to people flow changes and, relies on expensive and inefficient manual human labor. Staff needs to deploy and reposition the barriers at least a few times each day. Currently there are no commercially available crowd management solutions on the market that could replace the use of expensive and outdated physical barriers. Huti (TRL 6), developed by Blue Ocean Robotics (BOR), is an intelligent swarm of robots that will replace the physical barriers and barrier management personnel by providing a better flow of people, enhancing experience for travelers and decreasing costs for airports. This solution reduces labour costs needed to manage large crowds, provides better experience for the traveller and allows to quickly address changes in passenger flow or temporary closures. Huti was developed in collaboration with Vilnius International Airport, which showed interest and demand for such a solution. Blue Ocean Robotics is further working closely with the airport, which intends to be the first launching customer. The robot is the first innovative physical barrier that can work with minimal human intervention, providing queue management, guidance and entertainment functions. Huti robots creates a new market for robotic crowd management solutions. To ensure successful commercialization, in Phase 1 of SME Instrument, Blue Ocean Robotics intends to develop an elaborate feasibility study for Huti robot commercialization that would include: a thorough analysis of market and user needs, redesign of the product, and a business plan with an extensive financial, pricing, and IPR strategy.

Keywords: airport,robotics,people flow management
Medical Device Obligations Taskforce (MDOT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Austria,Germany,Germany,Germany,Germany,Spain,Austria,Germany,Germany,Germany,Poland,Switzerland,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,Luxembourg
Call: Open Innovation Test Beds for Safety Testing of Medical Technologies for Health (IA) (H2020-NMBP-HUBS-2018, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 8944243.75
EU funding (EUR): 8348633.5
Participants: 22
Project status: SIGNED

The new Medical Device Regulation (MDR) bears the potential to hamper Europe’s innovation competitiveness since reiterated, widened testing efforts are required. Especially SMEs must plan with early exits in the face of costly clinical studies. A structural remedial action reinstates the balance between economy and safety. The MDOT working group develops a set of coordinated measures: 1) Support with mandatory conformity assessment using a database approach based on device risk class. 2) Data exchange forum: A mutual, cross-enterprise exchange of medical device testing data on a safe and transparent platform, which aims at saving costs and streamlining clinical tests as far as possible. 2) Test foundry: Joint evaluations of commonly used parts and devices. 3) Development of advanced testing methods with a focus on in vitro and in silico data. This is all performed with regulatory support taking test beds and device innovations towards the level of clinical trials (TRL 4 – 7). This platform realizes one-stop-shop processing reducing complexity and individual costs. The operability of MDOT will be demonstrated within medical product segments growing fastest and with urgent medical need. The initial consortium consists of MD industry R&D, translational institutions and networks as well as clinical research centers. It will grant open access to new clients already during the funding period. Goal of the project is to implement the platform as a meta-network to preserve MedTech innovation and economic strength, reduce animal testing, and support MDR’s new level of patient safety.

Keywords: testing,regulatory,database,biocompatibility,network,blockchain,safety,medical device
Searching for novel strategies improving cancer immunotherapy (STIMUNO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Poland
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-03-01
End date: 2024-02-29
Duration (months): 60.0
Total project cost (EUR): 1498750.0
EU funding (EUR): 1498750.0
Participants: 1
Project status: SIGNED

The main goal of this project is to explore new fundamental pathways involved in the regulation of antitumor immune response. Since the immunosuppressive tumor microenvironment constitutes a key barrier to effective immunotherapy, our predominant ambition is to characterize novel, hitherto unknown metabolic changes that can support the survival of tumor cells and the escape from the immune surveillance. We have recently discovered a new metabolite within tumor microenvironment with a robust ability to inhibit the activity of immune cells and their potential to kill target tumor cells. Within the project, we plan to corroborate on our preliminary findings in order to establish the role of this factor in mitigating antitumor immune response. To this end, we will determine the level of its production within tumors in murine models. Moreover, we will relate these findings to human data by analysing the immune milieu and the expression of enzymes involved in generation of this metabolic agent in a cohort of cancer patients. We will also investigate the mechanisms by which this factor could perturb the functions of tumor-infiltrating effector cells. Finally, we aspire to use the knowledge gained during the implementation of this project to propose innovative therapeutic solutions. Specifically, we will investigate whether and how the inhibition of selected enzymes involved in the generation of this new metabolic checkpoint can impact on the efficacy of immunotherapeutic agents, including immune checkpoint inhibitors, arginase inhibitors as well as adoptive therapy with CAR-T cells and CAR-NK cells. We strongly believe that by achieving the goals of our project we will make a significant step forward in order to develop and to design cutting-edge therapeutic strategies. These compelling solutions would further improve the efficacy of tumor immunotherapy, thus contributing to a breakthrough advance in cancer treatment.

Keywords: cancer,metabolism,therapy,tumor microenvironment
Heating And Cooling Know-how and Solutions (HACKS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Austria,Germany,Spain,Italy,Norway,Lithuania,Sweden,Belgium,Poland,Switzerland,France,France,Czechia,Luxembourg,Portugal,United Kingdom
Call: The role of consumers in changing the market through informed decision and collective actions (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-09-01
End date: 2023-02-28
Duration (months): 42.0
Total project cost (EUR): 2159045.75
EU funding (EUR): 2159033.5
Participants: 17
Project status: CLOSED

The objective of Heating And Cooling Knowhow and Solutions (HACKS) is to achieve market transformation for heating and cooling (HAC) appliances by motivating consumers to replace old and inefficient equipment with new energy efficient equipment; and to encourage solutions that consume less fuel, lower energy bills and improve users’ comfort and health. In the EU, almost half of all buildings have individual boilers installed before 1992, with efficiency of 60% or less. The associated energy savings of a speedy replacement are immense. To achieve these goals, 17 HACKS partners in 15 countries will raise awareness on HAC economic and environmental benefits via a communication campaign, and 15 dedicated national online platforms that will provide clear, understandable information. The focus will be on HAC appliances (e.g. boilers for space and water heating, local space heaters, etc.), but also on solutions that lower the energy consumption and avoid the installation of new equipment (shading systems, thermostats, taps and showerheads). HACKS will engage consumers by assisting them during the purchasing process of new HAC equipment. The online platforms will provide tools to receive customized information, interactive comment functions, product information, and direct links to the suppliers of the product. The online platforms will also provide guidance on how to improve consumers' situation while avoiding the purchase of unnecessary equipment as well as how to use and maintain devices. Finally, HACKS will work with all relevant stakeholders (“the multipliers”) that participate in the decision-making process of consumers by setting up strategic partnerships to promote and facilitate the purchase of energy efficient installed appliances. HACKS will place a strong emphasis on installers, retailers and consumer organisations because of their proximity to the consumers and capacity to involve and bring guidance on energy efficient equipment directly to them.

Keywords: market transformation,consumer empowerment,involvement,heating,cooling,boilers,ventilators,non energy benefits financial,environmental,comfort bridging supply and demand of ee products
Developing methods to model local area temporal domestic electricity demand (Spatialec)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: New Zealand,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-12-01
End date: 2020-10-31
Duration (months): 35.0
Total project cost (EUR): 257017.35
EU funding (EUR): 257017.35
Participants: 2
Project status: CLOSED

The objective of this proposal is to implement a programme of research and impact activities intended to provide a step change in the level of understanding of, and modelling capacity for, spatially disaggregated temporal domestic electricity demand in a smart grid and demand response context. This programme will be developed in partnership with internationally recognised experts led by the University of Otago (host) who are pioneering in this field. It will be exploited via an applied research programme at the University of Southampton (beneficiary) which intends to integrate census, social science time use and detailed consumption data to develop local area level demand response models to support the analysis of a range of demand response scenarios. In so doing the fellowship will provide the applicant with a foundation from which to build a new career pathway by applying his substantial existing social scientific data analysis and spatial microsimulation expertise to the development and leadership of a substantial new European research capacity in an area of emerging commercial, societal and political significance.

Keywords: demand response,spatial microsimulation,electricity demand,time use,census
Generation and Application of Nucleophilic Allylmetal Species by Catalytic 1,4-Metal Migration (Nu14Mig)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-11
End date: 2017-06-10
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This proposed Fellowship brings together an Experienced Researcher from India with expertise in click chemistry, transition metal catalysis, and topochemical synthesis, with an internationally recognized Host Laboratory in the UK with expertise in the development of new catalytic reactions for organic synthesis. This project will: • Provide high-quality, tailored training for an outstanding scientist (possessing an excellent publication record) who is primed for an independent research career by complementing and enhancing his competencies. • Enhance European excellence in organic synthesis and catalysis, which are fundamentally important branches of chemistry that greatly impact upon many fields, such as the fine chemicals, pharmaceutical, agrochemical, materials, and biochemical industries. The proposed research is based upon a completely new synthetic method recently discovered in the Host Laboratory that enables the generation of nucleophilic allylmetal species, which are widely employed in organic synthesis to prepare diverse compounds of interest. This method involves the catalytic carbometallation of the alkyne of a 1,3-enyne, followed by 1,4-migration of the resulting alkenylmetal species to the cis-allylic position of the enyne, which constitutes a special type of C–H functionalization reaction. The resulting allylmetal species may then be trapped by an electrophile stereoselectively. It is our strong conviction that the possibilities of this chemistry are enormous, and the end result will be a generally useful synthetic method for the preparation of valuable building blocks as single enantiomers. This fellowship will therefore help Europe to remain globally competitive in the chemical sciences.

Keywords: transition metal catalysis,stereoselective synthesis,enantioselective catalysis