Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Transcription factors and regulation of AQP expression in maize stomatal guard cells and subsidiary cells (StomAQP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

The stomata are openings formed on the epidermis formed by two guard cells (GC) surrounded by subsidiary cells (SC), allowing gaseous exchange for photosynthesis at the expense of water via transpiration. Stomata are tightly regulated by the influx and efflux of water and small solutes across GC or SC membranes. The diffusion of these solutes and water through the membranes can be facilitated by aquaporins (AQPs). While there is insufficient knowledge on the precise role of AQPs in stomata, specific microdissection of the mechanism of AQP action in GCs and SCs affecting stomata is further limited. The superiority of grass stomata owing to their quick response make them apt for studying the role of AQPs in stomatal response, especially under abiotic stress condition since climate change has made crops worldwide extremely vulnerable. In this regard, maize is an appropriate grass crop to use as a model because of its economic importance. The overall goal of this project is to study the role of different AQPs, and their transcriptional regulation in stomatal complexes, that can be used to produce stress-resilient crops. We will be using transactivation assays, protoplast engineering, maize suspension cells, and CRISPR/Cas to achieve the objectives. The mechanisms uncovered here can be monumental to extrapolate the grass stress resilience mechanisms into other vital crops. This project will help add the experience required for my goal of being an independent group leader. I will gain from the scientific environment and the infrastructure and support system at LIBST-UCLouvain as well as from the vast experience of Prof. Chaumont in research and project management. In turn, the host will benefit from the technical skills, and creativity that I can offer.

Keywords: aquaporins,stomata,guard cell,subsidiary cell,crispr cas,gene editing,grasses,maize
urban WAste and water Treatment Emission Reduction by utilizing CO2 for the PROduction Of Formate derived chemicals (WaterProof)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Processes4Planet (co-programmed)
Countries involved: Netherlands,Spain,Germany,Iceland,Colombia
Call: Deploying industrial-urban symbiosis solutions for the utilization of energy, water, industrial waste and by-products at regional scale (Processes4Planet Partnership) (RIA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 9219914.0
EU funding (EUR): 9219914.0
Participants: 14
Project status: SIGNED

The WaterProof project proposes a resource efficient solution convert CO2 emissions from waste(water) processing into green consumer products. At the heart of the WaterProof concept is an electrochemical process that converts CO2, originating from waste incineration and wastewater processing, to produce formic acid. This reaction is paired with the generation of high-energy oxidants, which are used to remove persistent contaminants from wastewater thereby contributing to a clean water cycle with zero-waste. The energy to run the electrochemical process is provided by waste incineration facility. The formic acid is a feedstock for the production of Acidic Deep Eutectic Solvents (ADES). These ADES are used to extract precious metals from water treatment sludge and incinerator ash. Additionally, the formic acid is used for fish leather tanning to sustainably produce fish leather and will be tested in consumer cleaning products. The WaterProof technology results in a GHG reduction based on CO2 utilization, replacement of fossil feedstock and by industrial electrification. In the WaterProof project, a TRL 6 plant is constructed, including innovative downstream processing. The conversion of CO2 from wastewater treatment and the CO2 captured at a waste incinerator is demonstrated in two consecutive campaigns. To maximize impact of the WaterProof technology, life-cycle assessments and a full business case analysis are initiated in the early stage of the project to provide targets for technology development. A marketing and deployment strategy is developed to ensure social acceptance of the WaterProof technology. Besides the reduction of GHG emissions, WaterProof will have societal impact by, creating awareness trough interaction with policy makers and civil society and the creation of new jobs in innovative fields. By targeting an industry as essential as waste(water) treatment, WaterProof aims to create a concept that can impact society and climate on a big scale.
Quantum System-on-Chip based on silicon carbide (Q-Chip)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Luxembourg
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-07-01
End date: 2030-06-30
Duration (months): 60.0
Total project cost (EUR): 2998371.0
EU funding (EUR): 2998371.0
Participants: 1
Project status: SIGNED

A key question for modern quantum technology is: can isolated demonstrator experiments be united to implement real-world applications? Theory shows that by connecting quantum memories and processors, e.g., on a chip, surprisingly small systems can immediately achieve a quantum advantage. But the experimental implementation remains a grand challenge. Today, optically active spins in solids (colour centres) already implement quantum communication, computing, and memories – albeit individually. Pioneering efforts (including mine) focused on nitrogen-vacancy centres in diamond, but low material availability and difficulties in diamond fabrication hinder quantum chip developments. This project will realise a Quantum System-on-Chip with colour centres in an industrial semiconductor material: silicon carbide. Like a classical System-on-Chip, it will integrate separated processing and memory units, which are connected via photonic quantum communication lines. My mission goals are a) Entangling a quantum processor with a quantum memory; and b) Quantum processing based on instructions from the memory. To achieve these ambitious goals, I capitalise on two recent breakthroughs, which I spearheaded. My team developed the first quantum-grade fabrication of silicon carbide – and successfully integrated colour centres into nanophotonic quantum communication lines. Further, we recently investigated a new colour centre (the stacking-fault divacancy), which is the semiconductor twin of the nitrogen-vacancy in diamond. The similarity permits us to build upon established techniques and will ultimately allow demonstrating the long-proposed increased coherence times of nuclear spin qubits in silicon carbide. The successful project will initiate a transformative change towards reliable, cost-effective, and widely available quantum technologies – with Europe at the forefront of these developments considering that its silicon carbide industry is the global leader with >70% market share.

Keywords: quantum technology quantum communication spintronics nanophotonics semiconductor quantum optics
Collaboration with NSF on fundamental research on new concepts for distributed computing and swarm intelligence (DISCOVER-US)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Coordination and support actions
Countries involved: Belgium,Spain,France,Norway,Italy
Call: Collaboration with NSF on fundamental research on new concepts for distributed computing and swarm intelligence (CSA) (HORIZON-CL4-2023-DATA-01, 2023)
Start date: 2024-01-01
End date: 2026-06-30
Duration (months): 30.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 5
Project status: SIGNED

The DISCOVER-US project aims to (i) Strengthen long-term collaboration between the EU and the US by creating networking and collaboration opportunities to promote cooperation on new concepts and visions for the computing continuum, distributed computing and swarm intelligence. (ii) Facilitate brokerage events for on-going and future work streams in EU and US projects addressing the edge-cloud continuum. (iii) Implement research exchange and fellowship programmes to encourage and initiate collaboration. (iv) Create a EU-US collaboration support infrastructure consisting of various services: networking, brokerage, training, vision building, communication and dissemination. Content-wise, DISCOVER-US will focus on the following four key research topics for the collaboration. (i) Managing complexity through high levels of abstraction. (ii) New concepts for distributed computing, the computing continuum, swarm intelligence and edge intelligent things. (iii) AI-based concepts for self-organized, dynamic, and adaptive management. (iv) Collaborative programming frameworks and software development tools. DISCOVER-US will boost synergies, experience and knowledge sharing and lay the ground work for creating a EU-US collaborative research ecosystem for pre-competitive research in the computing continuum, distributed computing and swarm intelligence. It will strengthen the transatlantic research efforts in this area and also strengthen Europe’s position in the cloud to edge computing, and in the Internet of Things (IoT) and the tactile internet. This will be achieved by integrating relevant elements of computing, connectivity, IoT, artificial intelligence (AI) and cybersecurity. The project will run for 30 months, will deliver a vision on the computing continuum, distributed computing and swarm intelligence, create a transatlantic research community of about 100 senior researchers, and fund about 20 pre-competitive transatlantic research collaborations.

Keywords: distributed computing,swarm intelligence,iot
Tree-level biomass maps for Africa (TREEMAP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Denmark
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-06-01
End date: 2025-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Trees outside forests make up more than one quarter of the tree cover in Africa, but there is currently a lack of efficient and reliable monitoring systems for trees outside forests. Previous research suggests that most forest and landscape restoration (FLR) is occurring outside of contiguous forests, particularly in agroforestry systems. This implies that tree on fields, in particular those of smallholder farmers, as well as trees in restoration and plantation areas cannot be effectively and rapidly monitored. The ERC project TOFDRY has developed methods and tools that can fulfil these tasks, but the project outputs are not harmonized and not operational. The TREEMAP project aims at moving research into practical and needed application in Africa that facilitate the use of tree level biomass maps with end-users, such as governmental authorities or NGOs. TREEMAP will conduct a user needs assessment, and harmonize TOFDRY methods to develop operational products at two scales: (1) local/regional scale tree-level biomass maps using sub-meter resolution imagery, (2) annual high resolution biomass maps at national scale based on PlanetScope images, with a focus on dynamics in farmlands and restoration/plantation areas. Finally, TREEMAP will disseminate and distribute demo-products to end-users. TREEMAP will partner with AUDA-NEPAD, who is setting up in-country institutional arrangements to enable multi-sector use of the biomass maps. TREEMAP products will generate visibility on and verification of FLR efforts that can attract climate finance. Tree-level biomass maps contribute to Greenhouse Gas (GHG) inventories, the Agriculture, Forestry and Other Land Use (AFOLU) sector, Nationally Determined Contributions (NDC) reporting, and potential participation in carbon markets. Placing highly accurate, user friendly, regularly updated, analysis ready products in the hands of non-experts in Africa allows widespread participation in FLR monitoring and carbon markets.
Theater in Imperial Spain: studying a commercial activity during the first globalization from the perspective of labor and economic history (THIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States,Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-12-01
End date: 2027-11-30
Duration (months): 36.0
Total project cost (EUR): 265099.2
EU funding (EUR): 265099.2
Participants: 3
Project status: SIGNED

The overall objective of this project is to study the Hispanic theater professionalization process during the second half of the 16th century and the early decades of the 17th century from the perspective of labor and economic history. Furthermore, I approach this process in light of the first globalization, that is considering both Spain and its overseas colonies, as well as the interconnections between them. This is imperative because Golden Age professional theater has been and continues to be subject of many studies, especially philological, but we have not fully understood the basis of the functioning of this new profession that emerged in the mid-sixteenth century; the reason is clear: we are dealing with a commercial activity that has not been specifically and systematically studied as such, since, to do so, it is necessary to understand its economic and labor dynamics. In addition, professional theater has not been studied as a global phenomenon and this is also a serious problem because in the sixteenth century imperial Spain expanded into America and this fact cannot be ignored, much less if we are talking about a profession that developed almost at the same time on both sides of the ocean. The project has four phases. In the first one, a database will be created to collect and organize theatrical economic information; the database is intended to become an open-access tool. During the other three phases of the project, labor and economic history methodologies will be implemented to reconstruct cases of theatrical enterprises, to analyze the labor and economic conditions of different types of comedians and, finally, to calculate approximately the costs of staging a play at the end of the sixteenth century. Thus, this project would introduce new methodologies to theatrical studies and would inaugurate a brand new line of research founded on the economic history of an activity that is art, literature and also business.

Keywords: spanish golden age theatre,colonial theater,commercial theater,theater enterprises,comedians wages,costs of staging,global history,labor history,digital humanities
Rebuilding our world with new carbon elements that turn buildings into carbon storage structures (Elementic)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Finland
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 3567995.0
EU funding (EUR): 2497596.5
Participants: 1
Project status: SIGNED

Fifth Innovation Oy has pioneered Elementic - an innovative, carbon-ceramics material crafted from forest & agricultural side streams which are currently burnt for energy. Elementic valorizes lignin for the first time into a hard, structurally durable mono-material that stores approximately 3 kg of atmospheric CO2 for every 1 kg of material produced. With applicability in the construction sector as bricks, Elementic represents the most significant generation shift of the fundamental brick technology since mass production. Elementic bricks are lightweight, but sturdy; weather resistant; fire retardant; insulating; VOC and plastic-free; are sourced locally and can be completely recycled and reused at the end of life. Elementic is the next step in construction material sustainability, transforming buildings into carbon storages. Replacing an average detached household’s façade with Elementic is sufficient to negate the entire embedded CO2 footprint of the entire building.

Keywords: carbon ceramics,sustainable construction,construction materials,biomaterials,facade,bricks,forestry,lignin,biochar,sidestreams,side stream,novel materials,pyrolytic,inertinite
The development and marketing of Zealience Compliance Management Software (Z-CMS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 12.0
Total project cost (EUR): 500000.0
EU funding (EUR): 500000.0
Participants: 1
Project status: SIGNED

We are a cybersecurity start-up called Zealience GmbH. We have developed Zealience Compliance Management Software (Z-CMS) to help manufacturers of connected products comply with the upcoming European cybersecurity regulations, namely the Radio Equipment Directive Delegated Act (RED DA) (to be enforced in 2025) and the Cyber Resilience Act (CRA) (to be enforced in 2027). These regulations will mandate manufacturers to demonstrate sufficient level of cybersecurity in their devices. Our vision is to create a single platform where IoT manufacturers can perform and manage all the compliance activities. The compliance work required for these regulations is extremely arduous. As a former IoT cybersecurity evaluator, Zealience co-founder has helped manufacturers prepare for the regulations. However, he witnessed that it took about 18 months for them to become compliant. There is currently no automated tool available to help their work and everything is done manually. This is why we set out to develop Z-CMS. Z-CMS v1.0 available today automates the generation of technical documentation required to demonstrate compliance with the European standard ETSI EN 303 645 for consumer IoT products. We are currently working on the implementation of EN 18031, the new standards developed for the RED DA. We believe that Z-CMS is at TRL 7 as it is currently being tested by our pilot customer. It still requires further development to cover all the compliance activities of the regulations. Our goal is to reach TRL 9 by the end of this project (12 months). To this end, we need developers and sales to implement the features described in this proposal and bring Z-CMS to the market. The support of the EIC Accelerator program will greatly help us realize this endeavor. Our project not only addresses the growing demand of manufacturers in the face of the regulations, but also contributes to the successful implementation of the EU cybersecurity legislations.

Keywords: cybersecurity iot manufacturer regulations standards cra redda
IOO: a novel assay to predict patient response to immune checkpoint inhibitors, optimising patient stratification to these therapies and tripling solid tumour patient outcomes in immuno-oncology. (IOO - Improving IO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator Challenge: Novel biomarker-based assays to guide personalised cancer treatment (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 3565875.0
EU funding (EUR): 2496112.5
Participants: 1
Project status: SIGNED

Immunotherapy is a beacon of hope in cancer's battle, but with a 10-20% response rate in solid tumors, its potential is untapped. Predicting patient responses to treatment, which current methods are ill-equipped for, is an urgent unmet medical need. Our project stands for industrializing our analytically validated multiplexed protein-function based biomarker assay (IOO), currently TRL6, which is based on our proprietary bio-imaging technology. Whilst scientifically validated, we need further clinical validation to obtain increased datasets required for regulatory certification for clinical deployment. This assay could triple the efficacy of currently available immune-oncology treatments by accurately predicting patient response to immune checkpoint inhibitors - the basis of 90% of current immuno-oncology therapies. If successful, we will bring this transformative solution to hospitals worldwide. The upshot could be game-changing: doubling survival rates for high-prevalence, lethal tumors like lung cancer.

Keywords: immuno oncology,precision medicine,patient stratification,predictive assays,immune checkpoint inhibitor ici therapies