Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Portable Diagnostic Medical Device Based on Lab-on-Chip for Detection of Protein Biomarkers of Medical Interest. (PLATINUM)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Italy
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-08-01
End date: 2022-03-31
Duration (months): 68.0
Total project cost (EUR): 3116913.25
EU funding (EUR): 2171137.0
Participants: 1
Project status: SIGNED

The project aims at developing, prototyping, validating and bringing to market a portable assay system for the pre-diabetes and diabetes diagnosis and control, consisting of a disposable medical device equipped with a Lab-on-Chip (LoC) used for Point of Care or Self-Monitoring of protein biomarkers in biological fluids, like Glycated Hemoglobin (HbA1c). The medical device relies on a unique technology for diagnosis via protein biomarkers analysis, comprising a separation and a labelling stage of target molecule to detect and quantify the amount of glycated Hemoglobin in a drop of blood. The way this diagnostic medical device has been conceived and designed makes it unique compared to other devices available in the market. It is based on a disposable chip, easy to use, which does not require qualified personnel assistance and minimises manipulation. Stable at room temperature both in storage and during use, it does not need external calibration. These characteristics, together with its low cost, make it an excellent option for the final user (patient, pharmacy, hospital, etc.). The proposed diagnostic medical device consists of a LoC based on breakthrough microelectromechanical systems for protein detection through the protein biomarkers analysis. Such medical device is cheaper (€2-3/device), faster (~10 minutes), more robust (to vibrations, to high/low temperatures), more durable (2 years ambient-stored) and more versatile (easy to use, software-programmable, smart-phone integrated) than the already available and the foreseen portable alternatives, while being as precise as the costlier laboratory solutions. The project is relevant to the selected WP because it regards an innovative medical device for diabetes and pre-diabetes, thus with diagnostic and prevention applications, based on a solid feasibility study and a business plan. The project intends to bring the medical device from TRL7 to market. In addition, it already got the EC’s Seal of Excellence in 2015

Keywords: medical device,diagnostics,biomarkers analysis,lab on chip,ict for health,disposable,protein measurement
Wessex–Armorica: Territories, Connections and Hierarchies (WATCH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-16
End date: 2022-03-14
Duration (months): 27.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

The aim of the WATCH project is to model the organisation of territories, economic and political connections, and social hierarchies promoted and sustained by maritime connections across and around the English Channel during the early Bronze Age (EBA). This study is crucial to understand how communities living in the Channel coastlands became interdependent at a time when trade in tin and copper was strenghtening the foundations for an extensive prehistoric European union. Central to the project is the study of burials within their human, social, and natural environments using Geographical Information System (GIS) analysis. The project is interdisciplinary, rooted in archaeology but borrowing concepts, methods, and data from geography and environmental sciences. This project will enable the fellow to achieve the research and transferable skills, which will allow him to become a mature independent researcher and international expert of the EBA northwestern Europe. The fellow will be able to apply the most up-to-date GIS skillset to different problems in the field of prehistoric archaeology, which will extend an exciting research career. This project offers the opportunity to the fellow to conduct innovative research and transnational mobility while providing benefits for the European Research Area, the Bournemouth University, the supervisor, the partner organisation and the fellow. This project will allow the fellow to develop a research agenda that will lead to a range of research and consultancy projects with European academic and non-academic institutions for the better understanding of EBA societies and cross-Channel relationships, thus enhancing research excellence and addressing recognized research questions in Europe, and beyond. Finally, the fellow aims to offer civil society the demonstration of how and why both sides of the Channel became socially and economically interdependent in the past is relevant to considering the future of our societies.

Keywords: early bronze age,england,armorica,channel,maritory,networks,social inequality,economy,territories,landscape archaeology
full harvEst of solar radiatioN using a quantum-dot-in-perovskite absorber and LIGHT managemENt structures (ENLIGHTEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

Europe has set the energy transition to renewable sources as one of its priority policies to minimise the effects of climate change. Photovoltaic energy is called to play a major role in the world’s electricity production in the mid-term. The present market-dominant technology, crystalline silicon, has reached its practical efficiency record of 26% and the energy cost of this technology seems to be stagnating now. For these reasons, research on new ways of increasing the conversion efficiency of solar cells is still extensive. Among the proposed novel concepts for high-efficiency solar cells, the intermediate band solar cell (IBSC) has received great attention by the scientific community. In conventional single-gap solar cells, photons with energy lower than the bandgap of the absorber material are wasted. The IBSC concept allows harvesting below-bandgap photons without voltage loss, which increases the limiting efficiency from 33% to 50%. So far, IBSCs have been realized with epitaxially-grown quantum dot (QD) superlattices of III-V semiconductors. However, no pronounced efficiency enhancement has been yet reported, since this technological approach is unable to produce nanostructured materials with the properties required theoretically. In particular, epitaxial QDs exhibit low absorbance, leading to low photocurrent, and weak quantum confinement, which degrades the voltage of the cell. Recently, a new type of solution-processed semiconductor materials, quantum dots in a perovskite host (CQDs@Perovskite), has been demonstrated. The intrinsic opto-electronic properties of CQDs@Perovskite (high absorbance & strong quantum confinement) make them perfect candidates as absorber material in IBSCs. ENLIGHTEN will exploit CQDs@Perovskite materials combined with microstructure-based light trapping techniques to pave the way for low-cost high-efficiency solar cells. In addition, the cells have an innovative device structure compatible with flexible-substrate technology.

Keywords: photovoltaics,quantum dots,nanotechnology
Development and commercialisation of a safe, comfortable, adjustable and breathable body protector for dangerous sports industries. (Faze)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Sports injuries can result in an immense amount of long-term pain and suffering to the lives of those effected and even results in fatalities. This also results in a huge burden on EU hospitals, who spend €2.4 billion a year in direct health costs to treat patients effected by sports injuries. Horse riding is a particularly dangerous sport as the actions of horses can be unpredictable, making serious injury and fatality a possibility each time a rider mounts a horse. Chest and spinal injuries contribute to up to 26% of hospital admissions for horse riding accidents and injuries to both the body and shoulder are common in other dangerous sports such as mountain biking and snowsports. State-of-the-art: There are two main types of body protectors available for equestrians: inflatable air jackets (e.g. Airowear and Point Two Air) and panel-based jackets (Racesafe). The major issue with air jackets is that when they are inflated, they do not provide the rider with the flexibility to perform a “tuck and roll”, meaning that cannot quickly move out of the path of horses during falls, increasing the risk of crushing injuries. Panel based jackets are inserted with only a standard EVA based foam, which is an adequate level of protection to absorb the impact of falls or being stood on by a horse. We, Teqnox Ltd, have created a body protector “Faze” which is lightweight, breathable, and easy to adjust, whilst providing a high level of safety protection for the rider. Our innovate armadillo style design includes: • Overlapping and interconnected panels for rider flexibility, also ensuring no weak points. • A bespoke blend of two layers of soft and hard visco elastic foams to provide protection in high impact areas (chest and spine). .• A patent pending self-locking mechanism giving the rider a single point of adjustment to easily adjust the panels across the waist to fit any body type. • Inner and outer layers composed of impact resistant sports mesh for breathability.

Keywords: equestrian,body protector,horse riding,mountain biking,snowsports,foam
Nicotinic Acetylcholine Receptors nAChRs in Prostate and Colon Cell Cancer: pharmacology, mechanism, cellular (mal)function (nAChRs-CRC-PCa-IF-RI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: TERMINATED

Nicotinic acetylcholine receptors (nAChRs) are transmembrane ligand gated ion channels composed of five subunits and encoded by 16 genes. Depending on the subunit composition nAChRs have different properties and functions. It is widely accepted that smoking tobacco is correlated with several types of cancers and that nicotine and tobacco-derived nitrosamines are known to activate nAChRs contributing to oncogenic processes. To date the question of whether nAChRs contribute to the cellular malfunctions involved in prostate and colon cancer still remains unanswered. Our preliminary results show for the first-time different expression levels of nAChRs subunits in prostate and colon cancer cell lines. Most strikingly is the clear difference of expression of nAChRs subunits between cancerous vs. non-cancerous cells, depending on the aggressiveness and cell type. The question arises whether these differences have a physiological impact. In the present project I will investigate the pathophysiological role of nAChRs in prostate and colorectal cancer. My aim is to (1) Identify and characterize nAChRs involved in prostate and colon cancer; (2) study the role of nAChRs in migration, proliferation and invasion in prostate and colon cancer; (3) the influence of a duplicated isoform of the α7 nAChR subunit, dupα7, and its anti-angiogenic properties in CRC and PCa; and (4) the role of chemotherapeutic drugs, which could augment nAChRs expression in cancer and contribute to chemoresistance. The present project will be performed at the laboratory of Dr. Peinelt University of Bern, an established research group with a focus on the pathophysiology of ion channels in prostate and colorectal cancer and in collaboration with the Urology Department of the University Hospital Inselspital Bern. The Marie Curie IF will help me to further develop leadership skills, scientific maturity and independence and will be crucial for my aim to obtain an independent academic position in the future.

Keywords: nicotinic acetylcholine receptors,ion channel,cancer,prostate cancer,colon cancer,pharmacology
Electro-Weak corrections at the LHC (EWatLHC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

In view of the next run of the LHC, and of the impressive mole and quality of the collected data, accurate theoretical predictions will be mandatory in order to perform accurate measurements of the Standard Model parameters and to identify signals of the existence of new particles. If it is certainly true that impressive progresses have been achieved in the last years, in particular in the field of perturbative computations of cross sections and differential distributions, it is also true that much more has still to be done. The current proposal is focused on the computation of one class of corrections which affect LHC processes, the so-called NLO electro-weak correc- tions. This class of correction can have large impact in particular on events characterised by large energy scales, which will be more and more frequent at the next high-energy LHC run. Instead of proceeding on a process by process basis, the suggested path to follow is the one of automation, which has already proven successful in the case of NLO corrections originated by strong interactions. The automation of this class of corrections will allow to perform systematic studies about their effects on observables and processes relevant to the LHC.
Healing from Enclosure: A Political Agroecology of a Science-and-Society Potato Controversy in Belgium (HealingFromEnclosure)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Against the background of the ongoing crisis of the world’s food systems, this research project investigates how agricultural knowledge shapes, and is shaped by, its broader cultural, economic, socio-technical and socio-ecological context. A transdisciplinary approach –theoretically and empirically explorative, methodologically innovative, and action-oriented—to the production, transmission and application of agricultural knowledge in Belgium, and Europe more broadly, offers a powerful way of thinking about the complex relationships that exist between food systems and agricultural knowledge. Drawing on insights from a variety of disciplinary perspectives –ranging from political ecology, Science, Technology and Society studies, agroecology and ecofeminism—this project seeks to: (a) develop an interdisciplinary and transdisciplinary ‘political agroecology’ framework that broadens and opens up critical discussions on agricultural knowledges; (b) study processes of enclosure and commoning through the study of a science-and-society controversy around the development of genetically engineered potatoes in Belgium to frame agricultural knowledge trajectories; (c) involve ‘concerned groups’ –including farmers, researchers, policy-makers, NGOs and activists— in the development of strategies and actions for social innovation in agricultural knowledge systems. The innovative approach advanced in this research provides a necessary corrective to the prevailing yet partial views of existing approaches to agricultural knowledge systems. By using the lens of ‘political agroecology’, the project engages with the power dynamics inherent in the social interactions which are part of agricultural knowledge, while exploring possibilities for social innovation. The project is hosted at a global, interdisciplinary and policy-committed research centre for sustainability and includes a farmers’ organisation as a non-academic secondment partner to maximise the impact of the IF.

Keywords: transdisciplinarity,knowledge production,social innovation,agroecology,political ecology,ecofeminism,agricultural knowledge,potato blight,belgium,science in society controversy
Doctoral Industrial School for Vaccine Design through Structural Mass Spectrometry (VADEMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Denmark
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EID) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-11-01
End date: 2020-10-31
Duration (months): 48.0
Total project cost (EUR): 1096286.4
EU funding (EUR): 1096286.4
Participants: 2
Project status: CLOSED

Vaccines discovered from empirical approaches and consisting in killed, live-attenuated microorganisms or purified components have led to the successful control of many devastating diseases. Several novel technologies, such as recombinant DNA technology, glycoconjugation, reverse vaccinology have opened the possibility of designing vaccines previously considered impossible to make. Despite decades of efforts, vaccines have not yet been developed against several of the most life-threatening infections. Based on the observation that an efficacious immune response only require protective epitopes, structural vaccinology combined with human immunology are therefore rapidly emerging as a powerful alternative strategy for the rational design of vaccines bearing multiple protective epitopes and offering the opportunity of developing broadly effective immunity. The proposal is focused on the development of a Structural Mass Spectrometry platform and its application to compare conformation and dynamics of antigens in their native states (membrane) with their recombinant soluble forms (vaccines) and to get a better understanding of the humoral response raised against the two forms. The outcome of such studies will be to identify antigen portions accessible to the host immune system and those epitopes that can be recognized in the native form of the antigens to design efficient vaccines. Structural Mass Spectrometry is a very new science in Europe and the proposal represents the unique opportunity for 4 PhD students to be trained by an academic and an industrial group, leaders in respective parts of the field. The program will be complemented with a number of training courses. The students will receive a PhD degree in structural mass spectrometry applied to vaccinology. It represents a good occasion to spread this technology in Europe and good opportunities for students that are willing to grow both in basic science as well as innovative and applicative experimental research.

Keywords: structural mass spectrometry hydrogen deuterium exchange epitope mapping humoral response polyclonal antibodies monoclonal antibodies membrane proteins
X-10 Pathology, Empowering diagnostics (X-10 Pathology)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Italy
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

With the market introduction of X-10 Pathology we aim to shape a new era of healthcare and drive clinical testing to play a major role in prevention, diagnosis and disease monitoring. We are targeting a group of inflammatory-related pathologies affecting about 15-20% of the world population, for which no specific diagnostic assay is currently available. We want to stop the spiral of repeated tests and specialist consultations and offer patients a simple and inexpensive test on a powerful device, to have their disease identified and monitored in an accurate and timely fashion. To honour our mission we have developed X-10 Pathology, the first-ever device with demonstrated diagnostic capability on the specific causes of inflammatory conditions. Born from the synergy of cutting edge technical and clinical expertise, our standalone platform aims to provide a simple, cost-effective device that empowers also non-specialized personnel to provide fast and specific answers to patients with a minimally invasive test, also in developing Countries. We believe that the disruptive concept of X-10 Pathology has the enormous potential of empowering the healthcare system in its race to balance limited resources with the need of reliable and cost-effective diagnosis and treatment to a growing and ageing global population. Considering the advanced stage of development of our product and the successful outcome of preliminary clinical tests, we target the launch of X-10 Pathology in 2018, after obtaining regulatory approval. By joining the global market of In Vitro Diagnostics we will contribute to the growth of this sector, expected to reach € 66 billion by 2020. A feasibility study covering the technological, commercial and financial aspects will enable us to finalize our business plan and secure our steps towards the successful market launch.

Keywords: clinical test,pathology,diagnosis,disease monitoring,inflammatory conditions