Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Assessment of the risk of dissemination of environmental antibiotic resistance to human pathogens in aquatic ecosystems (REWARD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark,Singapore
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 263393.28
EU funding (EUR): 263393.28
Participants: 2
Project status: SIGNED

Antibiotic resistance is a major global public health threat. There is a growing concern that aquatic environments, which are in contact with the human microbiome in both urban and rural settings (drinking water, recreational bathing, crop irrigation), may serve as a reservoir of antibiotic resistance genes (ARGs) that might disseminate to human pathogens through horizontal gene transfer (HGT). However, the magnitude of this dissemination risk and the mechanisms involved remain unknown. REWARD (REsistance to antibiotics in Water: Assessment of the Risk of Dissemination) aims to identify the major drivers of human health risk and establish biomarkers for the monitoring and mitigation of antibiotic resistance dissemination in aquatic environments. REWARD will fill current knowledge gaps on the prevalence and ARG content of mobile genetic elements (MGE, plasmids and bacteriophages) in the aquatic environment, the frequency and genetic responses driving ARG HGT from these MGE to human pathogens, the impact of environmental and anthropogenic stresses on MGE prevalence and HGT frequency and the magnitude of the ARG dissemination risk to human pathogens in aquatic ecosystems. River and sea water from 8 aquatic ecosystems across Europe will be analyzed. The main drivers (MGE and genes) of ARG dissemination to fluorescent-labelled human pathogens added to surface waters will be determined using a combination of flow cytometry, last-generation metagenomic and metatranscriptomic sequencing technologies and newly-developed bioinformatic approaches for the reconstruction of MGE from metagenomic reads. Physiochemical and anthropogenic variables will be characterized in river water samples to establish dose-response links between anthropogenic and environmental stresses (including stresses linked to climate change) and ARG HGT in aquatic environments. Finally, a mathematical model to quantitively predict ARG dissemination risk will be developed using the data generated in REWARD.

Keywords: antibiotic resistance dissemination,molecular ecology,health risk assessment,bioinformatics,microbial ecology,horizontal gene transfer,freshwater microbiology
Integrating Multiscale Modeling of Metal Printing with Advanced Calibration and Characterization Techniques (IMMMPACCT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Binder Jetting (BJ) is an emerging additive manufacturing (AM) technology with greater flexibility on material selection and reduced residual stresses than fusion-based AM technologies. However, a deeper comprehensive understanding of the multiphase and multiscale phenomena involved in BJ is essential for its successful adoption. In this proposal, we will delve into the intricate mechanisms of BJ through the combination of various computational methods and the application of advanced statistical analyses. Our primary objective is to develop a robust computational framework that will facilitate a more precise comprehension of how the different stages of the BJ process interact employing different numerical methods, including Discrete Element Method for the simulation of the powder spreading stage and the Phase Field for the curing and sintering stage. The combination of these different techniques will enable us to unravel the complex interplay of factors at different scales, leading to a comprehensive understanding of the process kinetics. Moreover, the accuracy and reliability of the computational models will be ensured by the use of a custom-designed Bayesian calibration framework that will leverage existing collaborations industrial partners and advanced 3D X-ray characterization to obtain the required experimental data. Once completed, the calibrated computational framework will enable us to optimize critical parameters of the process (e.g. binder viscosity, layer thickness, powder properties) focusing on two high-impact steels (316L and 17-4 PH). Our project will advance the state-of-the-art in BJ technology by providing a comprehensive computational framework and bridge the gap between theory and practice. This framework will not only enhance our understanding of the process but also enable us to drastically reduce the occurrence of defects, paving the way for the widespread adoption of Binder Jetting in critical applications.

Keywords: multiscale modeling additive manufacturing binder jetting metals and alloys
Deciphering METAstasis of lung cancer to BRAIN and developing new therapeutic approaches via a human metastatic cascade platform (META-BRAIN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Türkiye
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-08-01
End date: 2029-07-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Brain metastases have a poor prognosis and are associated with a high morbidity and mortality rate in cancer patients. The metastatic pathways and the role of the blood-brain barrier (BBB) during metastasis are not known. There is a need to better understand cancer brain metastasis and develop effective therapeutics. With META-BRAIN, I will create a human-based in vitro platform that spans the entire cancer cell journey from lung to brain and use it to address three key questions: (1) How does cancer metastasize to the brain? (2) What is the role of the BBB in cancer metastasis to the brain? and (3) How and when can cancer metastasize be treated? The META-BRAIN will provide answers to these questions by developing a truly physiologically relevant human cell-based model, that for the first time, maps the entire cancer metastasis cascade and that can also be used to study novel target proteins at the blood-tumor barrier (BTB). This model will also be used to develop novel shuttle systems for drug delivery to the brain. By integrating state-of-the-art technologies from life sciences and engineering, META-BRAIN has three main objectives: (1) Develop an in vitro model that recapitulates the metastatic cascade with in vivo-like morphology and function to study how cancer metastases to the brain, (2) Investigate the role of extracellular vesicle (EV) and circulating tumor cell (CTC) migration events with a focus on their interactions with brain endothelia, and (3) Identification of novel target proteins specific to cancerous brain and development of novel nano-shuttle systems targeting these proteins to deliver therapeutics to the brain. In summary, META-BRAIN will lead the way in the development of physiologically relevant models for other brain-invasive metastatic cancers, open new avenues for the development of therapeutic and diagnostic approaches and pave the way for nano-shuttle formulations specifically designed to overcome the BBB and BTB.

Keywords: cancer metastasis,stem cell differentiation,microfluidic systems,nano shuttle systems,liposome,brain targeting,targeted drug delivery,extracellular vesicle,circulating tumor cell
Towards an Integrated Consistent European LULUCF Monitoring and Policy Pathway Assessment Framework. (PathFinder)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Norway,Germany,France,Netherlands,Czechia,Finland,Spain,Ireland,Belgium,Switzerland,United Kingdom,Croatia,Austria,Slovenia,Denmark
Call: The contribution of forest management to climate action: pathways, trade-offs and co-benefits (HORIZON-CL5-2021-D1-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 5788413.25
EU funding (EUR): 5788411.0
Participants: 24
Project status: SIGNED

Precise information on the current status of forests is required to forecast forest management effects which allows informed policy decisions. To inform and support the implementation of these policy objectives, PathFinder will develop and demonstrate an innovative integrated forest monitoring and pathway assessment system. This system, for the first time, will allow a consistent EU greenhouse gas reporting of the LULUCF sector, but, at the same time combine such monitoring capability with advanced pathway assessment to help plan the essential policy and implementation steps towards achieving the policy targets. The continuous monitoring of forests facilitates controlling of target achievement and possibly adjustment of pathways. PathFinder goes beyond the state-of-art by the most efficient, combined use of field and remotely sensed data for high-resolution mapping and precisely estimating forest attributes. The cooperation of the largest forest monitoring organizations operating in the EU, i.e., national forest inventories (NFIs) and the network installed under ICP Forests, provides a rich data base of harmonized ground truth information which will be complemented by an innovative field survey of consistently assessed field monitoring sites. Advanced measurement devices will provide an audio-visual digital twin including genetic properties of the consistently monitored forest for maximum transparency and interoperability of new data. The analysis of combined databases will improve our understanding of fluxes among C pools. The precise forest information of the monitoring system will feed into a new scenario framework that forecasts future forest scenarios and outcomes of forest management alternatives. The scenarios facilitate trade-off analysis of forest ES and are potential alleys in the pathway assessment. The pathway assessment is a co-creation activity in which novel monitoring and scenario studies are integrated with EU-level stakeholder visions and knowledge

Keywords: forest monitoring,pathway assessment
Bilberry Ecology and the Regeneration of forest Ecosystem Functioning (BEREFT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 226751.04
EU funding (EUR): 226751.04
Participants: 1
Project status: CLOSED

Human impacts such as clearcut harvesting have left forests bereft of the organisms that underpin their functioning. The decline of key plant species has reduced the capacity of forests to store carbon (C) and provide ecosystem services to the people of Europe. The regeneration of forest ecosystem functioning requires a deeper understanding of how the traits of its species can be linked to ecosystem processes. The BEREFT project aims to elucidate how the plant traits of bilberry, Vaccinium myrtillus, modulate the dynamics of C and nitrogen (N) within the boreal forest. The project combines advances in chemical ecology with an innovative experimental design situated in Norway pairing experimental plots in formerly clearcut forest plantations with those from near-natural forests. I will collect a comprehensive set of bilberry's chemical traits and test both in-situ and in-vitro experiments to determine the underlying mechanism linking bilberry traits to C and N dynamics. The project goes beyond the state-of-the-art in applying novel methods from chemical ecology to measure bilberry's traits and uses a creative design to link those traits to ecosystem functioning. Through the scope of traits measured and the innovation in experimental design pairing clearcut forests with near-natural forests, this project will significantly advance our knowledge of the ecology of Europe's forest ecosystems. I will receive training in chemical ecology to advance my career as an expert in data generation and exchange with the host my knowledge on long-term ecological experimentation and ecosystem functioning. The project will disseminate deliverables in trait data packages, an open-source chemical ecology pipeline, and a robust measure of the effect size of bilberry's impact on C and N in the boreal forest. Knowledge of bilberry's role in the forest C cycle can be exploited by forestry managers in efforts to maximize C storage to meet the EU's goal of carbon neutrality.

Keywords: ecosystem functioning trait ecology functional traits nutrient cycling
Engineering Magneto-ionic Materials for Energy-Efficient Actuation and Sensing: From Interfaces to Multifunctional Voltage-Tunable Micromagnets (ACTIONS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1994165.0
EU funding (EUR): 1994165.0
Participants: 1
Project status: SIGNED

ACTIONS proposes a material-based concept to drastically reduce the energy consumption of magnet-based micro- and nanotechnologies. Magnetic systems offer unique advantages for actuation in miniature fluidic and robotic systems, but their integration is hindered because electromagnets are required to create time-varying magnetic fields, causing joule energy loss and heat effects. Alternative control of magnetic materials using an electric field instead of electric current would present an energy-efficient solution. However, established magnetoelectric effects are small and restricted to low temperature or high voltage. Recently, we have demonstrated low-voltage control of magnetic films in liquid electrolytes by exploiting electrochemical reactions and ionic motion. ACTIONS targets the engineering of these emerging magneto-ionic materials to use their immense unexplored potential for low power actuation. The innovative strategy of ACTIONS is to transfer magneto-ionic effects of ferromagnetic metal thin films in liquid electrolytes to 3D nanomagnets and assemblies with defined anisotropy and at critical points. I will use a unique combination of in situ analytical and magnetic techniques to study the magneto-ionic control of magnetization; on this base I plan to attain magneto-ionic micromagnets with voltage-reconfigurable stray fields, which can potentially replace microelectromagnets. Additionally, ACTIONS recognizes the inherent cross-link between electrochemistry and magnetism in magneto-ionic systems as a ground-breaking route to combine actuation and sensing in one material. Interfacial chemistry sensing will be based on the electrical response. The final objective is to identify materials in which actuation and sensing can be programmed on demand by a voltage protocol. The concept in ACTIONS goes beyond conventional multifunctional composites and could establish a paradigm change in magnetic technologies and a novel class of energy-saving smart materials.

Keywords: magneto ionic,magnetoelectric,electrodeposition,voltage control of magnetism,nanomagnetism,
Reinvented through Crises: The Political Economy of the Western European Left within European Integration (CrisEU)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 277159.2
EU funding (EUR): 277159.2
Participants: 2
Project status: SIGNED

Due to recurring economic and political shocks, the past decade has consolidated crisis-management and resilience as a key priority of the European Union (EU). Academic research has long interrogated the ways in which crises are dealt with at the European level. Yet, the excessive emphasis on electoral trends or elite-led processes has failed to capture the long-term quiet politics of support towards European integration. The role of European progressives, a key source for the European ideals of solidarity and internationalism, has received little attention. This is surprising given the fact that progressive politics and European integration have both experienced a long series of mutations and adaptations shaped by recurring crises. While these processes have been studied separately, little attention has been given to their intersection. As a result, progressive politics has been conceptualised as a passive victim of increasing integration and the EU is often seen as squeezed in the middle between populism and technocratic decision making. CrisEU will build a theoretically informed and impact-oriented study to investigate the ideas and group characteristics that through critical junctures create long-lasting support to integration. The main hypothesis I will investigate is that progressive politics is ‘reinvented’ at different stages in relation to three interrelated factors: 1) The changes in the composition of left-wing social networks (in relation to gender, age, education, etc.); 2) The evolving memories of past crises; 3) The shifting understanding of what is needed to ensure Euorpean integration. Beyond academia, the proposed research will help political parties and trade unions identify the factors that drive (dis)integration within the EU, the ways in which memory informs crisis-management and the role played by social networks' pluralism in driving policy innovation.

Keywords: european integration crisis management left wing parties trade unions
Assesing efficacy and safety of genome EDITing approaches for Sickle Cell Disease - Hop-on Facility (EDITSCD-HOP-ON)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: France,Poland
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 60.0
Total project cost (EUR): 530750.0
EU funding (EUR): 530750.0
Participants: 2
Project status: SIGNED

Sickle cell disease (SCD) is one of the most prevalent monogenic diseases in Europe. A single amino acid substitution in the beta-globin chain of the adult hemoglobin (Hb) drives red blood cell sickling and multi-organ damage. The clinical severity of SCD is alleviated by the co-inheritance of mutations causing expression of fetal gamma-globin in adult life ? a condition termed hereditary persistence of fetal hemoglobin (HPFH). Transplantation of autologous, genetically modified hematopoietic stem/progenitor cells (HSPCs) is an attractive therapeutic option for SCD patients. To this end, genome editing approaches based on the use of site-specific nucleases or, more recently, base editors have been explored by many groups, including teams in our consortium. These approaches either correct the single point mutation causing SCD or reactivate fetal gamma-globin expression by mimicking HPFH mutations. On the other hand, (pre)clinical data from SCD patients or SCD mouse models, as well as preliminary data from our labs suggest that SCD HSPCs are characterized by a high mutational burden, oxidative stress and expression of inflammatory genes. This can alter HSPC properties as well as their interactions within the bone marrow niche. In the context of gene therapy, it is essential to understand the mechanisms underlying SCD HSPC dysfunction and assess the impact of genome editing approaches on SCD HSPCs. In this proposal, we have assembled a multidisciplinary team to: (i) understand the molecular and cellular mechanisms underlying SCD HSPC autonomous and non-cell-autonomous dysfunctions and (ii) evaluate the impact of established and novel genome editing approaches on SCD HSPC properties and genome integrity. This study will lay the foundation of an improved gene therapy strategy to treat SCD and provide best practice tools and protocols for genome editing-based therapies in HSPCs.

Keywords: genome editing,crispr cas9,safety