Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A novel approach into modeling origin and development of ovarian cancer (HGSOC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

High grade serous ovarian cancer (HGSOC) is the most common and lethal subtype of ovarian tumors, and is the 5th leading cause of cancer related deaths among women in the western world. Recent studies have pointed at the fimbriae of the fallopian tube (FT) as one of HGSOC’s main origins. The existence of FT stem cells (SCs) has been suggested, however, their isolation and characterization have been so far elusive. Given the potential of SCs to accumulate mutations, these cells may represent one of the cellular origins of HGSOC. This project is aimed at identifying SCs of the FT, evaluating their tumorigenic capacity and establishing a novel in-vitro human model for HGSOC development. Preliminary screening experiments of well-established SC markers have identified Lgr6 and Troy expression in the mouse oviduct. These putative SC populations will be further characterized and their capacity to maintain tissue homeostasis will be analyzed by lineage tracing experiments. Next, mouse and human organoid culture systems of FT and HGSOC will be generated. Mutating normal FT organoids in specific genes, using the CRISPR/Cas9 system, will enable following putative SCs tumorigenic capacity upon their injection to mice. Furthermore, it will generate an innovative in-vitro model of ovarian cancer development. Finally, HGSOC organoids will be used to model and follow chemotherapy resistance acquisition.

Keywords: ovarian cancer,fallopian tube stem cells,organoids
Middlebrow Enlightenment: Disseminating Ideas, Authors, and Texts in 18th-century Europe (MEDIATE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2021-08-31
Duration (months): 60.0
Total project cost (EUR): 1998125.0
EU funding (EUR): 1998125.0
Participants: 1
Project status: CLOSED

Intellectual history has long focused on a small number of authors and conceptual frameworks in studying societal change during the Enlightenment. Historians of the book have similarly restricted their vision, tending to privilege radical, subversive or forbidden texts. Yet ever since Daniel Mornet launched the history of the book approach a century ago, historians have recognized that it was authors who were not radical or subversive who produced the best-selling texts of the 18th century. This project will push Enlightenment studies in a new direction by moving beyond the present, narrow corpus of texts and models that dominate the field, and propose a new conceptual framework that takes as its starting-point the heuristic concept of middlebrow culture. Developing a state-of-the-art database, it will, firstly, identify not the ‘high’ Enlightenment texts studied by the history of ideas, and not the ‘low’, forbidden texts of book history, but the real best-sellers of the 18th century. These were the texts that, to readers on the ground, represented the most visible face of the Enlightenment, but have hitherto never really been studied. Secondly, it will elaborate a typology of this corpus describing its generic traits, intended readers, relation to major political-religious debates, and how readers in different parts of Europe appropriated these texts through translations, reworkings and other uses. Finally, it examines how historiography came to define the Enlightenment as the work of an intellectual elite, downplaying the impact of middlebrow texts and readers. The project thus brings an ambitious, bottom-up approach to intellectual history, using book history data and innovative digital tools to argue that the Enlightenment was fashioned not only by the progressive intellectuals we know today, but just as importantly, also by a large mass of forgotten, middlebrow best-sellers that need to be adequately studied if we are to truly understand how we ‘became modern’
Global Horizons in Pre-Modern Art (Global Horizons)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-09-01
End date: 2024-02-29
Duration (months): 66.0
Total project cost (EUR): 1904188.0
EU funding (EUR): 1904188.0
Participants: 1
Project status: SIGNED

The horizon is the line that seems to separate earth from sky, the line that divides all visible categories into two categories: those that intersect the earth’s surface and those that do not. The horizon is key to the experience of space; it defines our perspective on the visible world. The GLOBAL HORIZONS project will investigate the historical meanings and functions of the horizon in visual and intellectual cultures of the pre-Modern world on a global scale. Examining how pre-Modern cultures conceived of the horizon opens a crucial line of inquiry into understanding the many different ways in which humans have conceived of the relationship between an invisible cosmos and the visible world. Non-western art history is rarely taught at European institutions although countless important works of Non-Western art are kept in museum collections all across Europe. Including non-western concepts of pictorial space is key to the project, however, for Eurocentric models of art history have generally privileged the rise of the linear perspective. This framing has limited our understanding of the horizon’s complex rhetorical, visual and epistemological roles. The project’s specific question connects a variety of objects and epistemological categories, such as panel painting, manuscript illumination, profane und religious objects, cartography, travel accounts, and cosmological treaties. The applied methodological approaches will range from art history, visual studies and cultural anthropology. They will also draw upon interdisciplinary expertise, such as technologies of art production, history of science and philosophy. The project thus makes an important contribution to global art history, a highly innovative area in which only very few pre-modern topics have been addressed. It is the ultimate goal of GLOBAL HORIZONS is to suggest a new history of representation in Western medieval art.

Keywords: globalization,pre modern culture,transcultural exchange,horizon,perspective,painting,urban spaces,life world,representation
Seismic Functional Imaging of the Brittle Crust (F-IMAGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France,France
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2023-03-31
Duration (months): 66.0
Total project cost (EUR): 2434742.51
EU funding (EUR): 2434742.51
Participants: 3
Project status: CLOSED

Despite the dramatic impact of earthquakes, the physics of their onset and the short-term behavior of fault are still poorly understood. Using existing high quality seismic observations, we propose to develop a novel functional imaging of the brittle crust to clarify not only structural properties but also the dynamics of faults. We will analyze spatio-temporal changes of elastic properties around fault zones to highlight the interplay between changes in the host rocks and fault slip. Imaging the damage structure around faults and its evolution requires new seismological methods. With novel methods to image the highly heterogeneous fault regions, we will provide multi-scale descriptions of fault zones, including their laterally variable thicknesses and depth dependence. In parallel we will image temporal changes of seismic velocities and scattering strength. External natural forcing terms (e.g. tides, seasonal hydrologic loadings) will be modeled to isolate the signals of tectonic origin. This will also allow us to monitor the evolving seismic susceptibility, i.e. a measure of the proximity to a critical state of failure. Improved earthquake detection techniques using ‘deep machine learning’ methods will facilitate tracking the evolution of rock damage. The imaging and monitoring will provide time-lapse images of elastic moduli, susceptibility and seismicity. The observed short-time changes of the materials will be included in slip initiation models coupling the weakening of both the friction and the damaged host rocks. Laboratory experiments will shed light on the transition of behavior from granular (shallow fault core) to cohesive (distant host rock) materials. Our initial data cover two well-studied fault regions of high earthquake probability (Southern California and the Marmara region, Turkey) and an area of induced seismicity (Groningen). The derived results and new versatile imaging and monitoring techniques can have fundamental social and economic impacts.

Keywords: seismology,earthquakes,time dependent imaging,faults,earthquake source mechanics
Leveraging a novel platform technology to develop a first-in-class immunotherapy for Celiac Disease (SOMIT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2019-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Celiac Disease is a debilitating autoimmune disorder that is caused by intolerance to gluten. Although it is the most common genetically-based food intolerance in the world, there are currently no therapeutics available to treat patients. In this project, Allero Therapeutics will collaborate with two leading research institutes (Leiden University Medical Center from the Netherlands and the Veterinary Research Institute from the Czech Republic) to develop a first-in-class therapeutic against Celiac Disease. Specifically, this novel therapeutic consists of an antigen-specific immunotherapy combined with tolerizing agents, which will be delivered to the oromucosa via a proprietary sublingual mouth patch. This project consists of a 6-month multi-disciplinary feasibility study that will: (1) experimentally demonstrate in vitro and ex vivo Proof of Principle for the novel therapeutic; (2) research all required (pre)clinical development to build a detailed roadmap for navigating the regulatory landscape; (3) strengthen and expand the current IP position; and (4) consolidate all current and future findings into an investor-ready Business Plan.

Keywords: celiac disease,immunotherapy,antigen,autoimmune disorders,preclinical
Cloud Energy management solution for Office It equipment and Smart devices (POWERCLOUD)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Israel
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-2-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 1534577.0
EU funding (EUR): 1074203.9
Participants: 1
Project status: CLOSED

ICT industry requires a large amount of energy to power its infrastructure (Computing and networking mainly), accounting for 10% of global electricity consumption. The ICT sector direct emissions are expected to increase a 270% from 2002 to 2020. As electricity takes a larger portion of the SME costs, companies try to find new ways to reduce both the financial and environmental impact of this consumption. The addition of more electrical devices to the work scene such as Personal Computers (PCs), Laptops and printers, is increasing the energy consumption of the organisations. Nowadays, the office IT equipment accounts for approximately 24% of a modern office building energy demand. Moreover, according to International Energy Agency (IEA), energy used by these devices is expected to triple by 2030 unless actions are taken to increase energy efficiency. Regarding PCs, research shows that in Europe, approximately 28% of PCs being left on overnight in the UK, resulting in an estimated energy loss of 4,700 GWh (379 M€/year). In Germany, approximately 30% of PCs left on overnight, it is estimated 10,000 GWh/year of energy are wasted (819 M€/year). By 2015, it is predicted that software solutions which cut wasted power from computers and servers will save companies 13,800 M€. According to recent market reports, PC and Server Power Management Software is predicted to generate a revenue of 579 M€ by 2015 on a global scale and it is expected to grow at a Compound Annual Growth Rate of 15.8% . PowerPlug’s new offering aims to change this by providing a platform that will enable the management of IT and smart devices as part of a global energy management system as it happens with HVAC and lighting systems. PowerCloud system will provide manageability for the IT, visibility and usage patterns to energy managers and unique energy management and demand response features for service providers and utilities.

Keywords: green it,power management,energy management,laptop smart devices
AcceleGreat - SME Growth (SME Growth)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Finland,Belgium,France
Call: peer learning of innovation agencies (H2020-INNOSUP-2014-5, 2014)
Start date: 2015-09-01
End date: 2016-08-31
Duration (months): 12.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

The AcceleGreat project proposal aims at sharing experiences of the three innovation agencies composing the consortium: ARII-PACA from France, Enterprise Flanders & IWT from Belgium and MISET from Finland. As the “shared challenge” identified by the consortium is the way to accelerate growth of high potential enterprises, the main objective is to understand how agencies can provide a better innovation support to this kind of enterprises.

Keywords: sme growth
Quantifying the link between weathering and past CO2 levels (CONTROLPASTCO2)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2017-02-01
End date: 2023-12-31
Duration (months): 83.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The carbon cycle is a vital aspect of our planet’s well-being. However, there are fundamental aspects of it that we do not understand, without which we cannot accurately quantify CO2 budgets. How, and at what rate, does the carbon cycle respond to, and recover from, events of rapid and extreme global warming or cooling? What process has maintained the climate within a habitable range for billions of years? Silicate weathering is Earth’s main long-term CO2 removal process, and therefore a dominant climate control mechanism. Critically, we do not understand the controls on silicate weathering, or its full effects on atmospheric pCO2 and climate. The goal of this project is to determine and quantify how weathering responded during past periods of rapid climate change, using an innovative combination of novel stable isotope techniques, laboratory experiments and advanced carbon cycle modelling. This will determine the behaviour of a key, relatively unknown, factor in the carbon cycle. This project comprises three, highly novel, interlinked strands: 1) Examination of the palaeo-weathering record through recent glacial timescales using cave speleothems as a climate archive, 2) Determination of palaeo-weathering records through older, Cenozoic, rapid shifts in climate, using marine carbonates and clays as an archive, and 3) Advanced models to enhance our understanding of this record. This project will radically improve our quantitative knowledge of the controls over the carbon cycle. This is critical because 1) it is possible that weathering is the process that has maintained Phanerozoic climate in the relatively narrow bands required for life; 2) it is impossible to decipher the causes and consequences of long-term climate variations through Earth’s history without accurate weathering data; 3) detailed comprehension of rapid climate variations will enable more accurate predictions of future CO2 drawdown.
Hybrid Radio everywhere for everyone (HRadio)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Germany,Belgium,Belgium,France,United Kingdom
Call: Media and content convergence (H2020-ICT-2016-2, 2016)
Start date: 2017-09-01
End date: 2020-04-30
Duration (months): 32.0
Total project cost (EUR): 3248600.31
EU funding (EUR): 2953370.88
Participants: 8
Project status: CLOSED

HRADIO (Hybrid Radio everywhere for everyone) focuses on radio service innovations enabled by convergence. While radio, with its rich editorial content, remains a highly popular medium, listening figures are slowly declining, particularly among youngsters. With the rapid rise of smartphones, radio faces competition from many new services including music steaming platforms. Regular radio today often does not include attractive features as known from vertical platforms. And if present, they are mostly not well integrated with the actual radio programme. This is where HRADIO will deliver. Driven by the industry need to create attractive new radio experiences, the project will leverage the full potential of hybrid technology for radio – enabling the integration of cost-effective broadcast distribution with new online features. Broadcasters will be enabled to personalise radio services (while respecting privacy), to provide intuitive functionalities like time-shifting and, eventually, to foster and to exploit user engagement. HRADIO will pave the way to bring these features not only to broadcasters’ native mobile applications, but also to portals, to connected radios and into the car. The core approach is to integrate validated solutions and to harmonise APIs which together will provide broadcasters with an abstracted service layer accessible across any device and distribution platform – ensuring sustainability and return of investment. Therefore, consumers will be able to access their personal radio services on different devices and platforms enabled by a seamless broadcast-internet integration for radio content distribution. All features will be tested in 3 phases of large-scale pilots involving broadcasters, app developers for mobile and automotive devices. Eventually, HRADIO will publish its developments as ready-to-use Android and HTML client implementations including an extensive set of well documented APIs fostering new service developments for the radio sector.

Keywords: radio,hybrid radio,convergence,personalisation,new user behavior
HEalth data LInkage for ClinicAL benefit (HELICAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Spain,Ireland,Spain,Spain,Belgium,Sweden,Sweden,Switzerland,Switzerland,Belgium,France,France,Czechia,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 4050338.34
EU funding (EUR): 4050338.34
Participants: 27
Project status: SIGNED

European researchers have made leading contributions to the large genomic, transcriptomic and clinical datasets from patients with chronic diseases. Advances in information science provide unprecedented opportunities for using these datasets to elucidate the complex biology of these disorders, its influence by environmental triggers, and to personalise their management. Currently, exploitation of these opportunities is limited by a shortage of researchers with the required informatics skills and knowledge of requisite data protection principles. HELICAL addresses this unmet need by developing a trans-sectoral and interdisciplinary training programme that builds on the expertise and existing collaborations of its partners. It provides 15 early stage researchers with training in analysis of large datasets, using autoimmune vasculitis as a paradigm as it is scalable, and as comprehensive biological and clinical datasets are already available. The HELICAL training program focuses on three complementary areas: application of informatics to such datasets to gain new biological insights; translation of these into practical clinical outputs and management of ethical constraints imposed on such studies. The programme will be delivered through a multidisciplinary, trans-sectoral partnership of Academic and Industry researchers with expertise in basic biomedical research, epidemiology, statistics, machine learning, health data governance and ethics. Therefore, HELICAL exploits recent advances in data science to link research datasets with longitudinal healthcare records, based on the robust ethical foundation required for linkage studies using near-patient data, to address key experimental questions. The results will have obvious potential for transforming healthcare in the field of autoimmune disease. The training provided addresses a key skills gap in the European workforce and should make the ESR eminently employable in academic, industrial and clinical sectors.

Keywords: health record linkage