Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
European iNitiative for Low cost, Innovative & Green High Thrust ENgine (ENLIGHTEN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: France,Germany,Austria,Estonia,Italy,Belgium,Netherlands
Call: Low cost high thrust propulsion for European strategic space launchers - technologies maturation including ground tests (HORIZON-CL4-2021-SPACE-01, 2021)
Start date: 2022-11-01
End date: 2026-07-31
Duration (months): 45.0
Total project cost (EUR): 17586647.75
EU funding (EUR): 17585397.25
Participants: 18
Project status: SIGNED

The space sector is a source of economic growth, jobs and exports, participating in all Key Strategic Orientations of the EU strategic plan. Faced with growing competition and technological disruption it is vital to act in support of European space launcher development in order to preserve European independendant access to space. Confronted with smaller market than competitors and lower launch prices, European launchers must improve their competitiveness by halving launch price in the short term. In the long term, Europe will create common building blocks for an integrated and competitive European array of launchers of all scales with reusability functionalities. Europe must thus concentrate efforts on liquid propulsion system which can be half of the launcher cost and is an critical for reusability. In the frame of ENLIGHTEN (European iNitiative for Low cost, Innovative & Green High Thrust Engine), the consortium will strive to increase the competitiveness of european High thrust engine by preparing a demonstrator of Green High Thrust Engine based on Liquid Hydrogen using: • The latest advances in additive manufacturing to reduce the cost and number of engine parts • Edge AI & machine learning algorithm to develop the first space engine Health Monitoring System in Europe necessary to implement reusability • New low cost subsystems in Engine ignition, nozzle extension, valves and integrated flexible lines This future demonstrator, ENLIGHTEN, will achieve its goal of developing new technologies, would be tested in the frame of a future project in the High Thrust Engine P5 test facilities of DLR. ENLIGHTEN will achieve its goal to lower the cost of launch engines with its consortium mixing aerospace actors like ArianeGroup, AVIO, DLR and ONERA with start ups and SME working on ALM and AI as well as research organization/academia such as FraunHofer and KU Leuven and will rely on AZO to ensure dissemination of the results to benefit all industries of the EU.

Keywords: space propulsion,hydrogen,green high thrust engines,green hydrogen,alm,ai
Understanding the energetic cost of walking through computer simulations based on biophysical muscle models. (WalkEnergy)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 200400.0
EU funding (EUR): 200400.0
Participants: 1
Project status: TERMINATED

Metabolic energy consumption during walking increases considerably with disease, injury and age. We poorly understand why, because experimental estimates of energetic cost are limited to average whole-body measures. This lack of knowledge hinders the design of interventions that target walking energetics. Model-based computer simulations have the potential to predict energetics of individual muscles over time, and can be used to elucidate causal relationships between musculoskeletal properties and walking energetics. But current simulations vastly underestimate changes in energetic cost across walking conditions. I hypothesize that errors in predicting the energetic cost of walking are due to using Hill-type models and energetics models, which employ phenomenological relations derived from controlled experiments that do not capture muscle operating conditions during walking. In contrast, biophysical muscle models capture the mechanisms underlying muscle mechanics and energetics, but have not been used in simulations of walking. This project aims to gain fundamental insight into walking energetics through incorporating biophysical muscle models into simulations of walking, revealing contributions of individual muscles and gait phases to overall energetic cost, and predicting the energy savings enabled by assistive devices. This approach is feasible given my expertise with biophysical models and the host’s advancements in simulations, enabling the use of more complex muscle models. I will first develop a biophysical model that – when integrated in musculoskeletal simulations – captures whole-body energetics. I will then use the developed simulations to study muscle energetics across a range of walking conditions, and test the ability of the framework to predict exoskeleton assistance that maximizes energy savings. The developed (open-source) simulations may serve as a go-to tool to design interventions to improve mobility of individuals with increased energetic cost.

Keywords: musculoskeletal simulation,muscle force development,metabolic energy expenditure,biomechanics,cost of transport,crossbridge cycling,hill type models,huxley type models,muscle tendon dynamics
Photonic Spectrum Analyzer for the Terahertz Spectral Domain (PhoSTer THz)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-06-01
End date: 2023-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Scientific and commercial utilization of the Terahertz spectrum (100 GHz -10 THz) is often hindered by the lack of affordable characterization tools for developing systems towards maturity. This proposal aims for the prototype development of such tools, namely affordable spectrum analyzers (SA), in order to boost component development in the Terahertz domain (100 GHz-10 THz), particularly electronic and opto-electronic components. These are employed in 6G hardware, spectroscopy including bio-medical trace gas detection, security, non-destructive testing and quality control. To date's most employed systems are electronic frequency-extended microwave SAs. Whilst very powerful, they have a few draw backs: 1.) it is very challenging to develop electronic systems for higher THz frequencies. The highest commercial frequency extension to date goes to 1.5 THz. 2.) the higher the frequency, the exponentially more expensive are the frequency extenders. 3.) The extender modules are bound to specific waveguide bands. Spectra larger than 50% of the center frequency can only be obtained by employing several extender bands. In PhoSTer THz, we will implement a photonic spectrum analyzer system as opposed to electronic ones, with the following advantages: 1.) Spectral coverage from microwaves to several Terahertz with a single system without the need of exchanging bands. 2.) Accessing frequencies yet not accessible with commercial electronic systems 3.) Inexpensive solution: a single photonic system costs less than the electronic base unit (i.e. without extenders) PhoSTer THz emerged from the ERC grant Pho-T-Lyze (GA 713780) where the first versions of photonic spectrum analyzers were developed. In PhoSTer THz, we will bring the first prototypes close to market entry together with powerful commercial partners from the photonics industry. We will further aim to attract the interest of electronic spectrum analyzer manufacturers.
A CEMent harnessing EARTH for a sustainable built environment (EARTHCEM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 2
Project status: SIGNED

In the pursuit of a more sustainable future, green concrete stands out as a crucial innovation in the construction industry. Cement, the primary ingredient in concrete, is essential for its production but is responsible for approximately 9% of global CO2 emissions. Rapid urbanization and infrastructure development have further amplified environmental concerns, particularly regarding carbon emissions. The stringent targets set to combat climate change and achieve carbon neutrality by 2050 have driven the industry to seek effective solutions for reducing its carbon footprint. The EARTHCEM project is at the forefront of this transformation, exploring the potential of Limestone Calcined Clay Cement (LC3) to revolutionise the industry. By incorporating locally sourced clay materials and reducing clinker use, the project aims to minimise environmental impacts while optimising resource and energy efficiency. To ensure the durability and performance of LC3 under real-world conditions, the project will employ advanced accelerated testing methodologies, simulating long-term environmental exposure in shorter time frames. These tests will validate the mechanical properties, durability, and long-term performance of LC3, ensuring that it meets the rigorous demands of large-scale infrastructure applications. By providing the industry with a comprehensive and robust set of data, EARTHCEM will help to mitigate uncertainties related to the material’s behaviour over time, enhancing its appeal for broader adoption in construction. This initiative represents a significant approach toward sustainable development, aligning infrastructure advancements with ecological and economic resilience. Through innovative research, practical solutions, and rigorous accelerated testing, EARTHCEM is paving the way for a greener and more sustainable construction future.

Keywords: limestone calcined clay cement lc3,green concrete,low carbon cement,sustainability,clinker reduction,calcined clay,limestone
Ecotoxicogical assessment of banned and novel PFAS as individuals or in mixture (ECOPFAS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Luxembourg
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: SIGNED

The group of per- and polyfluoroalkyl substances (PFAS) are thermally and chemically stable with strong hydrophobic and lipophobic properties, making them highly suitable for many applications. However, they are part of the emerging chemicals identified to be persistent and bioaccumulative. They are very stable, non-degradable, and present all around the world. More than 9000 distinct individual compounds make up the PFAS group, with a carbon chain backbone between 4 and 14 C atoms in length, and a charged functional moiety: sulfonate or carboxylate. The two principal representatives and studied PFAS (perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS)) are banned in many countries, leading the major global manufacturers to find alternatives having shorter carbon chains (< C8) or with replacement chemistry with multiple ether-oxygens inserted between the perfluorinated carbon backbones, allowing the formation of non-covalent hydrogen bonds with a water molecule, which makes them more labile to degradation. However, those new chemicals have been identified in various environmental matrices are now becoming global contaminants. But our understanding of the PFAS alternatives toxicity is lacking in aquatic organisms and, in the case of emerging replacements and by-products, even not unexplored. Studies assessing their potential genetic, developmental, cellular, and systemic toxicities have not yet been conducted in aquatic organisms. To that purpose, the ECOPFAS project will investigate the acute toxicity, developmental toxicity, genotoxicity and toxicity pathways for PFAS alternatives in three freshwater species. ECOPFAS project will build on the expertise of the researchers involved together with the acquired data to provide a basis for a better understanding of the influence of the effects on individual and population fitness to support a broader integration of these data into risk assessment frameworks.

Keywords: pfas pfas alternatives ecotoxicity genotoxicity transcriptomics freshwater organisms
Efficient Detection of Squeezed Light on Nanophotonic Chips using Subwavelength-Engineered Superconducting Nanowire Avalanche Photodetectors (ESSENS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-04
End date: 2024-10-03
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: CLOSED

Quantum photonics has become a key driver for the development of novel applications—such quantum information processing and sensing—that leverage quantum effects to open new possibilities beyond classical capabilities. Squeezed states of light are particularly promising for such applications and have been employed, e.g., to conduct Gaussian boson sampling experiments. Despite the success of these experiments, the use of bulk optical components hinders scalability and phase stabilization. Thus, higher levels of photonic integration are strongly desired. However, the exploitation of squeezed light, which critically relies on efficient detection, has not yet been achieved using nanophotonic chips because of the limited efficiency of the required fiber-chip couplers and single-photon detectors (SPDs). In this project, an optical fiber–accessible, photonic integrated system will be implemented to demonstrate on-chip detection of squeezed light at telecom wavelengths. To accomplish this goal, two approaches will be employed to assist fiber-chip couplers and waveguide-integrated superconducting nanowire SPDs, enabling access to previously inaccessible regions of the design space: subwavelength grating (SWG) metamaterials and direct-laser-writing (DLW) fabrication technology. The outcome of this project will break new ground for exploiting squeezed states for applications in quantum simulation, communication, and sensing with hundreds of detectors and interferometers on highly integrated, monolithic chips with near perfect phase stability. This project will be completed in a leading interdisciplinary research group. The applicant’s background in integrated photonics and SWG metamaterial engineering will be combined with the expertise on quantum detectors and the DLW nanofabrication capabilities of the host group. The proposed work will expand the applicant’s experience, skills and professional networks, re-enforcing the advance of his career as an independent researcher.

Keywords: integrated quantum photonics,subwavelength grating metamaterials,superconducting nanowire single photon detectors,superconducting nanowire avalanche photodetectors,fiber chip couplers
Identification of chemical and biological determinants, their sources, and strategies to promote healthier homes in Europe (INQUIRE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: Research and Innovation actions
Countries involved: Norway,Belgium,Slovenia,Estonia,Sweden,Netherlands,Czechia,Australia,United Kingdom,Portugal,Italy,Finland,Germany
Call: Indoor air quality and health (HORIZON-HLTH-2021-ENVHLTH-02, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 7844543.75
EU funding (EUR): 7830787.0
Participants: 21
Project status: SIGNED

INQUIRE aims to protect citizen health by providing knowledge, tools, and measures to substantially improve indoor air quality (IAQ). We will conduct research and evaluate innovative actions to reduce hazardous chemical and biological determinants in homes, positively impacting the health of residents. INQUIRE will focus particularly on infants and young children (<5 years old) as highly sensitive groups that spend a substantial time in the home environment. INQUIRE will comprehensively advance our understanding of the determinants of IAQ in homes by implementing innovative, low-cost, non-invasive sampling strategies (sensors, indoor/outdoor passive sampling, urine biomonitoring) to characterize determinants of household IAQ and their importance to human exposure. To capture the breath of IAQ determinants across Europe, the study will monitor for one month over 200 homes distributed across 8 countries, covering a gradient of conditions in each country. Tiered high-resolution chemical and biological screening techniques and wide-scope holistic characterisation of hazards will provide a comprehensive assessment of the determinants of IAQ. Multifaceted data analysis techniques (including machine learning, exposure modelling, geospatial analysis), will link chemical, biological and toxicity profiles with drivers of IAQ to identify sources and prioritize pollutants. Source identification will feed directly into the testing of both novel technologies and readily deployable strategies to improve IAQ, resulting in evidence-based recommendations and a draft of policy strategy for developing IAQ standards. INQUIREs Open Science approach and generated FAIR data on hazardous determinants, their effects, risk factors and sources will endorse continuous exploitation of results. Open dissemination of generated knowledge will raise citizen awareness while exploitation by industry and policy makers will endorse a transition towards homes with zero pollution. The project INQUIRE is part of the European cluster on indoor air quality and health (name and acronym to be decided)

Keywords: indoor air quality,emerging contaminants,new determinants of iaq,fair data,open science
Translating Epigenetic Memory into Personalized Prognostic Solutions for Chronic Lymphocytic Leukemia (TEMPLe)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Predicting the future clinical behaviour of a patient’s cancer remains a major scientific and clinical challenge. Chronic Lymphocytic Leukaemia (CLL), the most common leukaemia in the Western world, exhibits a broad range of clinical behaviours. The disease begins with a premalignant state that can later progress into an asymptomatic, progressive and highly aggressive form with a poor prognosis. Predicting the risk and timing of progression is a major unmet clinical need in CLL. Through our ERC-SyG grant BCLLatlas and previous studies, we have revealed that DNA methylation plays a key role in cellular identity and memory. These observations indicate that: 1) neoplastic cells carry epigenetic imprints of their cellular origin allowing the distinction of epigenetic subtypes; 2) a mitotic clock traces the proliferative history of cancer cells; and 3) stochastically fluctuating DNA methylation serves as a molecular barcode to track cancer evolutionary dynamics. In CLL, all three nuances of epigenetic memory have a profound and independent prognostic impact. Can these independent prognostic variables be integrated into a single score? In TEMPLe, we propose to leverage the rich information on cellular memory that is encoded within the cancer epigenome by integrating these three variables and generating personalized risk-scores to predict future clinical outcomes of CLL. We will make significant steps towards developing solutions suitable for clinical translation by 1) generating a user-friendly digital platform for risk prediction and prognosis assessment, 2) defining the intellectual property (IP) strategy and best exploitation route in close collaboration with the Technology Transfer Office and IP experts. In the medium term this will improve the clinical management of CLL, and in the long term, this strategy could be applied to other cancers, providing a valuable global asset in precision oncology.
Remote-Sensing Satellite Data and the Making of Global Climate in Europe, 1980s-2000s. (CLIMASAT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 1484844.0
EU funding (EUR): 1484844.0
Participants: 1
Project status: SIGNED

Answers to how to manage the urgent climate crisis depend on perceptions of global climate. Knowing how they came to be is necessary to open up new possibilities about ways to face it. CLIMASAT aims at establishing a truly comprehensive narrative that integrates various spheres of knowledge to understand how global climate discourses, policies and practices came into being in the approximate 1980s-2000s Europe. To do so, CLIMASAT substantially places the production, circulation and use of data generated with Earth-orbiting satellites at the centre of historical analysis. Indeed, since the 1980s, much of our scientific, practical and political knowledge about global climate has been increasingly compiled with satellite data, in a process of constitutive co-production. Then processes of data production, circulation and use may have played a role in knowledge-making. CLIMASAT identifies 5 interrelated spheres of knowledge involved in satellite data production, circulation and use: science and technology, economy, regulation, communication, and diplomacy. It sets out the hypothesis that it was through their mutual intersections, as they materialised in processes of data production, circulation and use, that certain perceptions and actions about global climate were collectively negotiated, shared, maintained and used. It focuses the empirical analysis on 3 European satellite programs (Meteosat, Topex/Poseidon, ERS) that provided data on extreme weather events, sea level, and ozone. It demands an interdisciplinary methodology grounded on material and transnational history. In times of growing public concern regarding our actions on the climate crisis, CLIMASAT delivers unparalleled information and critical analysis about how satellite data-informed perceptions of global climate were made, which is relevant not only for researchers in academia but also for policy-makers and engaged citizens.

Keywords: satellite data,europe,1980s 2000s,history of climate,data history,history of space technology