Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Wearable Sensor for Hormones Based on a Native Microbial Sensing (SENSHOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-15
End date: 2020-07-03
Duration (months): 36.0
Total project cost (EUR): 264668.4
EU funding (EUR): 264668.4
Participants: 2
Project status: CLOSED

Connected devices that monitor human biology in real-time represent the next frontier in biosensors. Monitoring hormones is of significant interest as hormones play critical roles in multiple physiological processes including stress adaptation, blood pressure control, reproductive rhythms, and body odor. However, the real-time monitoring of hormones is challenging from a biology, chemistry, and engineering perspective, insulin detection being the one notable success. This project proposes to design a novel wearable device to sense estradiol (through sweat), a hormone responsible for fertility issues and mood disorders in women. This project is highly innovative and ambitious since it combines microbial genetics and protein identification, new polymer and nanoparticles compositions, and a novel sensor design. The wearable device (i.e., bracelet) will contain an optical-to-electrical interface for recording the fluorescence output of a biosensor, based on estradiol sensitive transcription factor isolated from a microbial organism. The biosensor is composed of biopolymers (dendrimers and polypeptides nanoparticles) functionalized with fluorescent molecular beacons (MB) and a hormone-sensitive transcription factor. Without the hormone, the two fluorescent entities of the MB are linked by the protein and no signal is emitted because of fluorescence resonance energy transfer (FRET), while in the presence of estradiol, the MB separate and a fluorescent signal is emitted. The project will be conducted in two international prestigious laboratories in France and in the USA to give to the applicant the best interdisciplinary scientific environment, and ensure the ultimate success of this project. The applicant will be the main spokesperson and lead investigator of the project. This international exposure and this fellowship will provide the applicant a unique and multidisciplinary profile, while facilitating her future academic career as a researcher in France.

Keywords: biosensor,hydrogel,connected device,polypeptide,dendrimer,molecular beacon,bioengineering,synthesis,hormone
Runtime Exploitation of Application Dynamism for Energy-efficient eXascale computing (READEX)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: High Performance Computing
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Germany,Germany,Norway,France,Czechia
Call: HPC Core Technologies, Programming Environments and Algorithms for Extreme Parallelism and Extreme Data Applications (H2020-FETHPC-2014, 2014)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 3534198.75
EU funding (EUR): 3534198.75
Participants: 7
Project status: CLOSED

High Performance Computing (HPC) has become a major instrument for many scientific and industrial fields to generate new insights and product developments. There is a continuous demand for growing compute power, leading to a constant increase in system size and complexity. Efficiently utilizing the resources provided on Exascale systems will be a challenging task, potentially causing a large amount of underutilized resources and wasted energy. Parameters for adjusting the system to application requirements exist both on the hardware and on the system software level but are mostly unused today. Moreover, accelerators and co-processors offer a significant performance improvement at the cost of increased overhead, e.g., for data-transfers. While HPC applications are usually highly compute intensive, they also exhibit a large degree of dynamic behaviour, e.g., the alternation between communication phases and compute kernels. Manually detecting and leveraging this dynamism to improve energy-efficiency is a tedious task that is commonly neglected by developers. However, using an automatic optimization approach, application dynamism can be detected at design-time and used to generate optimized system configurations. A light-weight run-time system will then detect this dynamic behaviour in production and switch parameter configurations if beneficial for the performance and energy-efficiency of the application. The READEX project will develop an integrated tool-suite and the READEX Programming Paradigm to exploit application domain knowledge, together achieving an improvement in energy-efficiency of up to 22.5%. Driven by a consortium of European experts from academia, HPC resource providers, and industry, the READEX project will develop a tools-aided methodology to exploit the dynamic behaviour of applications to achieve improved energy-efficiency and performance. The developed tool-suite will be efficient and scalable to support current and future extreme scale systems.

Keywords: dynamic auto tuning,application dynamism,system scenarios methodology,performance,exascale
Synthetic aPerture Interferometric raDiometer for sEcurity in cRitical infraStructures (SPIDERS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: France
Call: Critical infrastructure protection topic 7: SME instrument topic: “Protection of Urban soft targets and urban critical infrastructures” (H2020-SMEINST-2-2014, 2014)
Start date: 2015-10-01
End date: 2018-05-31
Duration (months): 32.0
Total project cost (EUR): 1166000.0
EU funding (EUR): 816200.0
Participants: 1
Project status: CLOSED

Along with the evolution of nature and frequency of threats on various critical infrastructures and soft targets, there is a need for evolution and improvement in the detection solutions of hidden objects or materials that can represent a menace to European citizens and assets. Current long queues at airports or administration security checkpoints and bulky scanners will soon be seen as outdated with the coming technologies. As the number of transportation hubs and sensitive location for common security are increasing (airports, power plants, prisons, administrations) passive scanning system, not emitting any radiation, represent the most promising opportunities. Such systems require to tackle ethical issues such as the displaying of personal bodies and still be able to detect hidden objects. Other technical challenges have to be met in order to integrate such detection solution into the everyday life : 3D analysis, real-time detection, spatial resolution. SPIDERS project, built from the results of recent FP7 project to propose the latest passive millimeter wave technology with a synthetic aperture interferometric radiometer. The French company MC2, specialised in radiometric sensors and microwave products and services, aims at developing its business on the rising markets of PMMW technology for security applications and tackle all the stated technical and business challenges to demonstrate a fast 3D scanning system of walking people and detection of hidden objects and materials. The SPIDERS will represent a budget of 1,2 million euros and start in 2015 for 24 months.

Keywords: critical infrastructure,passive millimeter wave radiometer,synthetic aperture interferometric wave,stand off scanning,hidden object detection,airport,nuclear plant and prison security
Marine Knowledge Sharing Platform for Federating Responsible Research and Innovation Communities (MARINA)

Framework: Horizon 2020 — Science with and for Society
Programme: Integrate society in science and innovation issues, policies and activities in order to integrate citizens' interests and values and to increase the quality, relevance, social acceptability and sustainability of research and innovation outcomes in various fields of activity from social innovation to areas such as biotechnology and nanotechnology
Action type: Coordination and support actions
Countries involved: Estonia,Spain,Italy,Ireland,Cyprus,Belgium,Romania,Türkiye,France,Portugal,Denmark
Call: Knowledge Sharing Platform (H2020-ISSI-2015-1, 2015)
Start date: 2016-05-01
End date: 2019-04-30
Duration (months): 36.0
Total project cost (EUR): 2999943.75
EU funding (EUR): 2999943.75
Participants: 14
Project status: CLOSED

The Marina proposal overall aim is to create an all-inclusive Knowledge Sharing Platform (KSP) catalysing and organising the convergence of already existing networks, communities, on-line platforms and services providing an online socio-technical environment that facilitates and stimulates the direct engagement of researchers, Civil Society Organisations (CSOs), citizens, industry stakeholders, policy and decision makers, research funders and communicators for improving Responsible Research and Innovation. In particular, the project will establish, curate and experiment a Responsible Research and Innovation platform involving societal actors working together during the whole research and innovation process for aligning better both the process and its outcomes, with the values, needs and expectations of European society, integrating citizens visions, needs and desires into science and innovation, promoting RRI with focus on marine issues and pressures that have important effects on the European societies. The project activities and outcomes, even if connected with marine research field, will define this systematic approach in order to make it transferable and reproducible for any RRI thematic domain. All project results and activities will be extrapolated from the RRI marine field to general RRI and broadly disseminated. The expected outcome of the Work Programme is a clear improvement of the integration of society in science and innovation. The MARINA project will follow this strategic line of “strengthening and facilitating” the capacity of the research and innovation to align and integrate the social needs through a suitable knowledge sharing platform and federating activities.

Keywords: knowledge sharing platform,socio thechnical ecosystm
My own bio-imprint as asset for competitive advantage (MYBIOASSET)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Spain
Call: SME boosting biotechnology-based industrial processes driving competitiveness and sustainability (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

"Microorganisms are the basic pillars of global industries like wine production, brewing and bread making. Producers elaborate useful and valuated products controlling the microbial activity on the raw material to obtain the desired results. In these sectors, in most cases, two opposite drivers determine the competitive strength and position of each competing company:• The singularity and differentiation of the product. This driver is the responsible for the scarcity component of the competitive advantage. A company is more competitive in the extent their products cannot be replicated by competitors. Influences mainly the “price” component of the marketing mix; the more singular and scarce the higher margin to raise the price.• The efficiency and robustness of the production process. The other component of competitive advantage is related to the excellence in operations. The production capacity and the optimization of processes, increase the profitability through reduction of production costs and defective product.In most cases, very differentiated or high quality food requires complex and expensive processes; and very efficient and robust processes drive to undifferentiated and standardized products. This is the case of wine industry, in which differentiation of the product has been sacrificed in favour of efficiency of the process. LEV2050 was created to recover the ancient diversity of wines while benefiting for most modern production technologies. This document is particularly relevant for winemaking but the business principles are scalable to any microbiota based industry.With LEV2050 winemakers can, at the same time, develop their competitive advantage from the differentiation of their products, and from the efficiency and robustness of 100% trustable fermentation processes"

Keywords: yeast wine non saccharomices
Olea expansion and mosaic Landscape formation in an island Environment since human Arrival (OLEA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

The Mediterranean sylvo-agropastoral landscapes resulting from a long-term co-evolutionary process between socio-environmental and climate variables are at the centre of interest for environmental and social key issues linked to the creation of mosaic landscape. Islands provide vital insights for understanding cultural and environmental dynamics on a long-term perspective as they tend to amplify geographical and cultural determinants. The Balearic Islands constitute an invaluable laboratory for studying these interactions during the Holocene. OLEA project focuses on drivers and timing of the spread of Olea macchia as a central feature of the current Balearic landscape. The history of Olea horticulture and management since the earliest human arrival to these islands may be exemplar of Mediterranean dynamics. To attain these goals with a holistic approach, high-resolution palynological studies (coastal lagoon cores and archaeological sites), pollen morphology (Olea varieties), multi-proxy analysis (pollen, NPPs, sedimentary charcoal), fire history (natural or anthropic fires), paleoenvironmental-ecological-archaeobotanical-archaeological data integration and agent-based modelling (ABM) will be combined. In doing so, several Training Objectives will be achieved, including: improvement of morphological skills of microremains identification, new knowledge on Mediterranean vegetation, use of computational modelling and development of transdisciplinary and transferable skills. OLEA project will offer novel approaches and methods to understand mosaic landscape formation in the Mediterranean, history of managing and cultivation of cultural trees and how past societies faced climate oscillations and societal transformations in fragile island environments during the last millennia of changes.

Keywords: palynology,archaeobotany,island archaeology,olea,vegetation history,climate change,mediterranean,multi proxy,balearic islands
ITO-free multi-coloured nanoscale engineered OLEDs for large-area flexible lighting and full-colour active-matrix displays (FlexNanoOLED)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-10-01
End date: 2019-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

FlexNanoOLED aims at expanding the groundbreaking research developed within the ERC project SUPRAFUNCTION into a radically new and unprecedented technology to enable the fabrication of flexible ITO-free multi-coloured nanoscale engineered organic LEDs. In a recent breakthrough, we have developed a novel device architecture for optoelectronics which relies on a nanomesh scaffold and demonstrated its full potential by realising supramolecular nanowire photovoltaic devices with performances surpassing those of standard organic photodetectors. The nanomesh technology can be exploited to other devices in strategic S&T areas. In particular, it offers an effective solution to satisfy the demand for large-area flexible lighting and full-colour active-matrix display for printed e-wallpapers, rollable screens and luminous advertisement boards. In this PoC, we will use our nanomesh scaffold to fabricate polychromatic high-performing OLEDs supported on plastic substrates. Ink-jet printing will permit the selective integration of different colours into pre-designed patterns to realise >300 cm2 sized customised images with a pixel resolution of 50 μm. OLED represented a $4.9 billion industry in 2012; it now requires novel solutions for being implemented on flexible supports. Towards the FlexNanoOLED technology commercialisation, we will define the exact exploitation strategy, including IPR positioning, market survey, business model and fundraising once the device key performance indicators will be optimised. This will also include partnering with key enablers (business-related and/or technological) for commercial success. Within FlexNanoOLED, we will gain technical and commercial proof of concept, to develop the prototype and ultimately bringing this unprecedented OLED technology closer to the market, with the overall goal of increasing the share of Europe in the field of OLEDs, a technological realm that Europe has pioneered yet has lost the dominance of since a decade.

Keywords: oleds,large area flexible optoelectronics,recyclability,ink jet printing,full colour active matrix display,nanomesh scaffold,ito replacement
Automatic Hitching for total Safety of Farmers when Coupling machinery (SIWI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Modern farm tractors provide most of the muscle power needed for today's high output agricultural enterprises. However, with current practices, they are also dangerous, with a number of fatal occupational accidents estimated at three times higher than the average. Power Take-Off and contact with machinery attachments (known as hitching) are one of the main causes. A routine task in farming is to connect the tractor with a trailer or tool. Current approach is to do it manually, requiring the operator get near the connection, hence, the injuries. We have developed the first fully automated hitching system, SIWI. With our system the operator can connect/disconnect the tractor from the seat, not having to get anywhere near the connection. Moreover, productivity is dramatically increased since a trailer change is done in just under 30 seconds! Instead of the current 15-20 minutes. Reduced cost, operation time and increased safety and comfort are SIWI USPs. Moreover, our solution is a great fit for farmers with disabilities. Our market is huge (150,000 new tractors registered every year in the EU), and the interest already raised has been great from customers and distributors, locally, within Europe and even from Japan. We have already sold 40 units of our current prototype. With the support of the SME Instrument we aim to overcome its current limitations to make it 100% efficient functionally and scale-up production, reducing the price and increasing profit margin, to be able to meet the great demand expected. Our solution is already patented, which will be updated through Phase 2.

Keywords: hitching,tractor,farming
Decoding neural circuits controlling sleep drive and sedation (DNCSS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Sleep and anaesthesia are both commonplace states that involve reversible loss of consciousness. However, the precise regulatory mechanisms underlying both still remain elusive, particularly at the circuitry level. Previous studies suggest that sleep is homeostatically regulated and it has been proposed that the interaction between circadian rhythm and intrinsic sleep drive determines sleep status. Although much efforts have been made, the sleep field still lacks clarity regarding the nature of the “sleep drive” as well as how it modulates sleep homeostasis. My host lab recently revealed that neuronal ensembles in the PO area, particularly in the lateral PO (LPO) area, a small region at the base of the brain that contains a mixture of sleep-active, wake-active, and temperature-sensitive neurons, are selectively activated during recovery sleep and drug-induced sedation. These results indicate that the LPO neurons are able to sense the sleep drive. In this proposal my goal is to identify LPO associated functional connectivity encoding sleep drive and sedation. By combining TetTagging functional ensembles of neurons with in vitro and in vivo optogenetics, electrophysiology and imaging techniques in mouse, I aim to 1) evaluate alterations of excitatory/inhibitory inputs onto the defined LPO neurons during prolonged wakefulness and sedation; 2) identify the origin of inputs onto the defined LPO neurons; 3) tdetermine the effects of altered connectivity involving active LPO neurons on sleep and sedation status in vivo. The results of the proposed research will provide novel insights into the regulatory mechanisms underlying sedation and the homeostatic drive of sleep.

Keywords: sleep,neural circuitry,hypothalamus,gabaergic neurons,synaptic transmission,tettagging,retrograde tracing,rabies virus,optogenetics