Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MIcrobially MEdiated Particulate Organic Carbon flux (MIMEPOC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-06-01
End date: 2025-07-31
Duration (months): 26.0
Total project cost (EUR): 190401.01
EU funding (EUR): 190401.01
Participants: 1
Project status: SIGNED

Particulate organic carbon generated by primary production in surface waters is exported into the ocean’s interior through the biological pump, contributing to the regulation of atmospheric carbon dioxide and partial sequestration of ocean carbon. Microbial transformation mechanisms on sinking aggregates directly impact the quantity and quality of organic matter reaching the deep sea. Due to their importance in biogeochemical cycles, sinking particles and their microbial components have received increasing attention in the past few years. However, microbial interactions and mechanisms involved in particle formation and degradation remain largely unexplored. The overarching goal of the current project is to explore for the first time the specific functions of particle-associated prokaryotes in determining the fate of sinking particulate organic matter (POM). First aim is to investigate in situ the RNA-based functional and genomic characteristics of sinking particle-attached microbes over time at different depths, using metatranscriptomics and metagenomics analyses. We also aim to elucidate the protein-based functional profiles of microbial communities on sinking particles and uncover linkages between microbial enzymes involved in the degradation of POM, using a comparative metaproetomics and metagenomics approach. Additionally, we aim to examine the carbon uptake, metabolic activity and colonization patterns of sinking-particle-attached microbes, using stable isotope probing coupled with amino acid tagging and liquid chromatography mass spectrometry. It is anticipated that the insights provided into microbially mediated processes regulating POM transformation will set the basis for better understanding the oceanic carbon cycle, and further improve predictions on future ocean biogeochemical cycles and climate change.

Keywords: environmental microbiology microbial oceanography biofilms marine snow sinking particles biological carbon pump particulate organic carbon metatranscriptomics metagenomics
INNOVATION EXCELLENCE IN CONSTRUCTION ENGINEERING: NOVEL 3D CONCRETE PRINTING TECHNOLOGIES AND SUSTAINABLE MIXTURES (EXEP3D)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Information Science and Engineering
Countries involved: Estonia,Netherlands,Germany
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 1499197.41
EU funding (EUR): 1499197.41
Participants: 3
Project status: SIGNED

The EXEP3D project aims to expand skills, transfer knowledge, and raise the innovation capacity of TTK’s Institute of Civil Engineering in the field of construction engineering with the aim to become a leading competence centre in Estonia and Europe, more specifically in 3D concrete printing (3DCP) and locally produced sustainable mixtures. By linking the unique competencies of Eindhoven University of Technology and TU Dresden – the two leading universities in automation and 3D printing technologies for construction engineering and environmentally friendly mixtures – the project has potential to innovate the construction engineering industry as a whole. With a wider aim to fill in the gap within EU and raise the scientific and technological excellence of TTK as a representative of Estonia, a Widening country, EXEP3D proposes a combination of staff upskilling, academia-industry partnership-building and applied research activities while consulting with academia and industry experts. Within 36 months, the consortium will deliver 8 staff study visits, 13 training seminars for staff and students/researchers, a student competition, 2 open-access publications on the newly established research direction in cost-efficient 3D concrete printing formwork and locally produced mixtures, technical descriptions and data sheets on the novel approach, and annual events with the industry to introduce and further disseminate project results, to name a few.

Keywords: innovation transfer,construction engineering,3d printing,capacity building,twinning
Autonomous Drones for Nature Conservation Missions (WildDrone)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark,Germany,Netherlands,Switzerland,Kenya,United Kingdom,United States,Namibia,Italy
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2952586.88
EU funding (EUR): 2777787.77
Participants: 20
Project status: SIGNED

The aim of WildDrone is to push wildlife conservation practices into the 21st century. The need for effective, cost-efficient conservation practices are greater than ever as we currently face the greatest loss of global biodiversity in history. Present conservation practices are typically very labour intensive, costly, and time-consuming. Collected data is often inaccurate or incomplete. However, recent advances in drone technology have shown that this technology has great potential as a practical tool for conservationists and that it could potentially revolutionize our efforts in nature conservation. Nevertheless, drone technology is still a developing field and many obstacles stand in the way of us harvesting the benefits of this emerging technology. To fully achieve its promising potential in this new domain we will need to invent more robust and predictable robotic technologies, including effective and automated means of gathering and interpreting ecological and behavioural data. WildDrone will address these challenges by joining the scientific areas of aerial robotics, computer vision, and wildlife ecology. The network proposes to develop new autonomous drone technology, expand current computer vision capabilities, and combine these advances to create practical tools for visual inspection and monitoring of wildlife populations. This drone-based inspection will provide conservationists with crucial knowledge of animal health, behaviour, and numbers. These challenges will be solved by 13 PhDs (three self-funded). An interdisciplinary research training programme has been designed to educate a new generation of PhDs and provide them with a unique skill set enabling them to tackle the great challenges we must solve collectively, if we are to reverse the decline of global biodiversity. This program will raise the level of excellence in doctoral programs and simultaneously enhance the career perspectives of the PhDs in both academia and industry.

Keywords: drones,autonomous systems,uas,computer vision,nature conservation,animal behavior,human wildlife conflict
A two-fold added value to SMARTdrugs: patient-derived cellular screening towards an organ-on-a-chip device (SMARTdrugs-PT)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Germany,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 30.0
Total project cost (EUR): 578103.75
EU funding (EUR): 578103.75
Participants: 2
Project status: CLOSED

In oncology, less than 10% of phase III clinical trials successfully meet their primary end-point due to a lack of adequate experimental preclinical models that consider human cell-cell interactions and closely mimic the disease's pathophysiology. In SMARTdrugs-PT, our vision is to create a new multi-assay screening platform for radiotheranostic-supramolecular compounds, bringing added value to the ongoing project SMARTdrugs. iMM will be in charge of a new work package, with three specific objectives: 1 – Evaluation and characterization of the translocation of the blood brain barrier (BBB) by the supramolecular compounds currently under development 2 – Activity testing in patient-derived 3D models of supramolecular compounds 3 – Integrated evaluation of the combined efficacy (BBB crossing/anticancer activity) of supramolecular compounds in the human organ-on-a-chip model of brain cancer – device proof-of-principle validation This novel preclinical drug screening platform involves innovative methodologies and cutting-edge techniques. It will better represent the human setting, contributing to select improved druggable leads under preclinical assessment. iMM will leverage a diverse combination of patient-derived tissues, histological assessment, analytical and spectroscopic methods, as well as microscopy techniques to better characterize the supramolecular compounds available in the network. In addition, in a longer term, our ambition is to combine these assays into a single device consisting of a patient-derived cancer organ-on-a-chip, which incorporates a BBB model. This technology can be used to develop drugs against brain cancer and other central nervous system malignancies, thus, extending the impact of our work far beyond the limits of the proposed project.

Keywords: supramolecules,theranostics,imaging,therapy,cancer,blood brain barrier
European Birds of Passage - An Empirical Legal Theory of Temporary Labour Migration in Europe (E-BoP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1395888.0
EU funding (EUR): 1395888.0
Participants: 1
Project status: SIGNED

The E-BoP project is an innovative study of the legal framework for temporary labour migration in the European Union (EU). While unevenly researched, the subject is hotly debated and in continuous expansion. Temporary labour migration increasingly represents the compromise between calls to "take back control" of borders, and the demands from employers of access to migrant workforce. The legal regulation of this phenomenon is grounded on concepts, such as "temporariness" and "labour market", which are either not defined by the law or in conflict with their socio-economic reality. E-BoP explores these concepts through an empirical legal analysis to address the foundations of the legal framework for temporary labour migration in the EU. In doing so, it covers forms of temporary labour migration which legal doctrine has never analysed together, namely posting of workers, seasonal work, and intra-corporate transfers. The project aims to answer a set of questions concerning this legal framework: what is the implicit definition of "labour market" accepted by legislation and courts, and what are its boundaries? What does the law mean when it classifies certain migrant workers as "temporary"? What would be the legal and socio-economic consequences of conceiving temporary labour migrants as fully integrated in the Member State where they perform their work? The E-BoP project triangulates the results of a systematic analysis of legal documents with quantitative analysis of the phenomena at stake to explore the real world meaning of concepts upon which the legal regulation of temporary labour migration in the EU is construed. As such, the ambition of E-BoP extends beyond the field of labour and social rights, and into other legal disciplines and branches of social sciences. Considering how the legal construction influences employment statistics, leading to the undercounting of temporary labour migrants, the project challenges the societal perception of reality.

Keywords: temporary labour migration european union law empirical legal research migration statistics posting of workers seasonal workers
Driving manufacturing SME transformation towards green, digital and social sustainability (GreenSME)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Coordination and support actions
Countries involved: Spain,Italy,Germany,Denmark,Ireland,Poland
Call: 'Innovate to transform' support for SME's sustainability transition (CSA) (HORIZON-CL4-2021-RESILIENCE-01, 2021)
Start date: 2022-06-01
End date: 2025-08-31
Duration (months): 39.0
Total project cost (EUR): 4897921.25
EU funding (EUR): 4897920.0
Participants: 10
Project status: SIGNED

Manufacturing is among the key driving forces of the European economy and their engagement is a must to achieve Green Deal goals. greenSME project aims to drive manufacturing SME towards green, digital, and social sustainability. To achieve this main goal, the project will strength SME capacity for advanced technologies adoption to become competitive and climate neutral, maximising the benefits for all parts of society. This vision implies SMEs to develop a strategic approach to sustainability. The project vision, EU manufacturing industry sustainability shift, will be achieved through greenSME HUB which gathers sustainability awareness and industry engagement activities, ecosystem networking space and tailored advisory services to SMEs through the SME sustainability transformation pathway. ?The greenSME HUB will become a knowledge sharing area that gathers resources, activities, and stakeholders to enable the uptake of AT by SMEs for sustainability. ?SME sustainability transformation pathway. The pathway gathers the whole process of guidance that will be given to the SMEs for their shift towards sustainability. ?The SMEs that have developed a greenSME sustainability assessment will be eligible to apply for financial support. The project will dedicate a budget of 3 MEuros for supporting SMEs in the implementation of the sustainability strategy action plans greenSME project is firmly committed with open science policy, and project exploitable result will be shared and disseminated. Project main outcomes are: 1) EU manufacturing SME sustainability Roadmap, 2) greenSME HUB. A knowledge sharing community that gathers manufacturing ecosystem stakeholders and all the developed sustainability communication material within the project, 3) greenSME sustainability assessment tool and Advanced Sustainability Action plan (ASAP) definition methodologyand 4) SME Sustainable pathway and AT implementation good practices white book.

Keywords: green deal,open call,manufacturing sme,advanced technologies,social innovation
New industrial process for footwear manufacturing using 3D Bonding (3D Bonding)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 1843318.54
EU funding (EUR): 1290322.0
Participants: 1
Project status: CLOSED

The 3D BONDING project addresses a disruptive process, based on a family of patents (Simplicity Works- PCT/ES2012/07001369) for highly automated and robotised manufacturing of high-end footwear. Through a polymer injection process, we bond materials in 3D (instead of stitching), that creates a stable skeleton without overlapping seams, in a few seconds. This technology eliminates the need of complex stitching operations, improving the mechanical properties foot the footwear (adaptation, comfort, and permeability). 3D Bonding simplifies footwear manufacturing reducing the total number of operations to 20 (70 for traditional manufacturing), reducing labour costs associated to stitching and assembly by 72%, and using 50% less material. Moreover, the carbon footprint is 13% less than a traditionally made product. Our 3D BONDING project can bring back to EU the manufacturing process, resulting in reduced delivery times, multiple job positions and a stronger economy for the EU.

Keywords: automation and control systems,manufacturing and processing,engineering and technology,3d bonding,footwear,reaction injection molding,automation,circular economy,robots
Metal EXsolved CATalysts for the CO2 valorisation to methanol: design, synthesis, and characterisation of next-generation catalysts, unravelling their structure-activity relationship (MEXCAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,United Kingdom
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 2
Project status: CLOSED

The European Union goal of a 80-95% decrease of greenhouse gas emissions by 2050 requires, among other strategies, new functional materials and sustainable approaches for clean energy generation and pollutant abatement. The chemical valorisation of CO2 is a highly promising green solution involving the recycling and reuse of CO2 effluents as carbon source for fuels and chemicals, such as methanol. The low CO2 conversion, triggered by catalytic nanoparticles (NPs) deactivation by sintering and limited selectivity, however, limits its industrial growth. The first aim of this proposal is to design next-generation stable and selective catalysts for the CO2 hydrogenation to methanol, that can rival state-of-the-art materials through the ambitious achievement of 10% methanol yield. This will be done by NP exsolution, a novel route to achieve stable anchored NPs, which has barely been explored for this application, despite the superior catalytic properties unique to exsolved systems. To then unravel the lack of fundamental understanding in the catalytic mechanisms of exsolved systems, we will characterise the correlation of their structure with their reactivity and selectivity via a unique in situ/operando approach (second aim). The role of active sites such as exsolved NPs and structural defects will be elucidated by in situ/operando Infrared (FTIR) and Raman studies; we will monitor the composition and strain evolution of the materials surfaces during catalytic processing by state-of-the-art in situ photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). The unique expertise of the host supervisor in CO2 hydrogenation catalysts testing and characterisation by in situ/operando FTIR and Raman, and of the secondment group in XPS studies of catalysts on-stream, coupled with my experience in exsolved systems design and in situ TEM characterisation will advance the fields of exsolution and CO2 valorisation catalysis, allowing me to gain a unique skillset.

Keywords: nanoparticle exsolution,co2 hydrogenation to methanol catalysis,in situ infrared spectroscopy,operando raman,high pressure photoelectron spectroscopy,in situ transmission electron microscopy
CRISPR Point-of-Care Diagnostics (SCOPE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2022-09-01
End date: 2024-02-29
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Monitoring of human health and the prevention/treatment of (infectious) diseases strongly depend on accurate and efficient detection, identification and tracking of pathogens or biomarkers. Key features of such a diagnostic tool that enable this are speed, accuracy and availability at the point-of-care. Current molecular diagnostic solutions do not meet these requirements due to the fact that they often need to be performed in a centralized fashion. However, the incredible advances in CRISPR-Cas technology in recent years provide an opportunity to change this. By taking advantage of the innate specificity of CRISPR-Cas we have previously developed a highly sensitive and accurate proof-of-concept diagnostic tool with promising results. The potential for implementation is unfortunately impaired by the fact that the workflow comprises of multiple steps that increases hands-on time, room for human error and the undesirable implications this has. To mitigate this, we propose a solution that entails developing a novel approach based on a thermostable RNA polymerase that allows for the condensation of the current workflow into a shorter 1-step protocol. Once such a protocol has been developed, an assay will be developed for one of the causative pathogens of chronic obstructive pulmonary disease (COPD). Technical feasibility of the assay will be demonstrated, in collaboration with an academic hospital, by characterizing the developed assay on relevant clinical samples. This will provide insight into the real-life performance when compared to the current gold standard (PCR) as well as ease-of-use in a relevant context. Furthermore, the feasibility of the value proposition and potential for commercialization will be thoroughly assessed. Not only will this ERC-PoC project shed light on the potential for our improved CRISPR-Cas based diagnostic tool in the context of COPD, a sense of broad applicability in other human Point-of-Care diagnostics applications will be gained.