Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Polychromy: the meaning of Colour in Roman African statues (PolyCRomA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

Long neglected, the polychromy of ancient statues has been increasingly studied during the last 20 years with a multidisciplinary cooperation between humanities and natural sciences. If the use of colour seems omnipresent in Greek statues with an illusionistic aim, the phenomenon is not only understudied in Roman statues but also more ambiguous: the fashion for copying Greek statues seems to develop the taste for marble and the socio-political value of the statues could be reflected in the use of colour. This action explores the meaning of Roman Imperial statues polychromy in Proconsular Africa though the Bardo museum collection in Tunisia, proposing the first systematic study of the use of colour in the statuary of an important Imperial province. The variety of typology, quality and provenance (local, Asia Minor, Rome workshops) of the more than 100 coloured statues in the corpus offers a significant mirror of the African society. Moreover, as the archaeological context of discovery is well known, the meaning of the polychromy will be analysed in relation with the socio-political and religious purpose with which these artefacts were conceived. The preserved traces of colour will first be documented by coupling visual investigation (by the support of multispectral imaging and UV and VIL videomicroscope) and in-situ analyses (XRF and µRaman) in order to identify the techniques used to colour the statues. Selected micro-samples will undergo further quantitative analyses (PIXE, SEM/EDX, hyperspectral imaging, FT-IR). Finally literary and epigraphic sources of Proconsular Africa mentioning the colour of statues will be inventoried and the use of colour on the statues will be compared with their counterparts in painting and mosaic. The overall evaluation of the data will go beyond the scope of the province and will reach wider conclusions on the variations in the use of colour and its meaning, contributing to the history of colour and the modern perception of Roman art.

Keywords: tunisia,roman africa,statues,polychromy,pigments,visual aesthetic,painting
Dissecting the protection mechanism of new generation vaccines by synchronizing systems biology with in vivo imaging (VacTrack)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-12-13
End date: 2024-12-12
Duration (months): 36.0
Total project cost (EUR): 281358.72
EU funding (EUR): 281358.72
Participants: 2
Project status: SIGNED

Despite successful reduction of the burden of many infectious diseases by vaccination and the strong improvement of vaccine safety, there is a strong need to improve existing vaccines and to develop new affordable vaccines with greater efficacy. Particle-based vaccines are one of the recent advances, with potentially a promising impact on global public health. Besides being investigated for their protective potential, the knowledge about their mechanism of protection is still scarce. VacTrack is designed to investigate this by innovatively combining state of the art in vivo imaging with global transcriptome analyses. I aim to dissect the route vaccines acquire inside the host along with the spatio-temporal changes in gene expression following vaccine exposure to the host, by utilizing pneumococcal antigens grafted to outer membrane vesicles (OMVs) as model formulations in imaging-assisted in vivo mouse vaccination and challenge infection models. VacTrack is expected to generate insights about novel pathways triggered in host following vaccination which will be further validated by an ex vivo approach via stimulation of murine and human whole blood. By exploiting systems biology, high resolution in vivo imaging and immunological approaches VacTrack will provide a blue print for the approach to study mechanism of protection of vaccines in general. Comprehension of correlates of protection by combining in vivo and ex vivo analyses will 1) help devise new pneumococcal vaccines, 2) improve existing vaccine formulations, 3) transform the direction of vaccine research by allowing targeting of specific novel pathways identified via VacTrack. Taken together, this proposal holds great potential in advancing the vaccine research to devise new and better vaccines to save and improve human lives on a global level.

Keywords: vaccination,immunity,particle based vaccines,pneumococcal vaccine
Pro-Internationalization Policy in the European Union The Challenge of Policy Efficiency and Coherence Post Lisbon (PI-PEC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The proposal introduces a novel technique, which has been developed by the fellow, Dr Miguel Torres (MT), in Portugal, to prototype pro-internationalization policy using a streamlined and innovative combination design of top-down and bottom-up approaches. The prototypes to improve policy design efficiency and coherence (PDEC) within each of the European countries, and in the European Union as a whole, will be realised through understanding the decision-making function relationships between companies and policy makers. The approach will employ questionnaires to policy makers, which have designed past incentives towards internationalization; and firms, which have used these same incentives. The insights gained will be used to generate models to explain the behaviour of both managers and policy makers in their actions and to arrive at set of principles of action for PEC. The work plan will be executed at the University of Leeds at a time when there is an EU policy (Lisbon Treaty) highlights the need of coordination of policies, the coherence in external relations, and the consistency with the potential complementarities between trade and FDI within EU members and considering third countries. "

Keywords: policy design,public support,optimization,coherence,development
Data-centric Parallel Programming (DAPP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-06-01
End date: 2021-09-30
Duration (months): 64.0
Total project cost (EUR): 1499672.0
EU funding (EUR): 1499672.0
Participants: 1
Project status: CLOSED

We address a fundamental and increasingly important challenge in computer science: how to program large-scale heterogeneous parallel computers. Society relies on these computers to satisfy the growing demands of important applications such as drug design, weather prediction, and big data analytics. Architectural trends make heterogeneous parallel processors the fundamental building blocks of computing platforms ranging from quad-core laptops to million-core supercomputers; failing to exploit these architectures efficiently will severely limit the technological advance of our society. Computationally demanding problems are often inherently parallel and can readily be compiled for various target architectures. Yet, efficiently mapping data to the target memory system is notoriously hard, and the cost of fetching two operands from remote memory is already orders of magnitude more expensive than any arithmetic operation. Data access cost is growing with the amount of parallelism which makes data layout optimizations crucial. Prevalent parallel programming abstractions largely ignore data access and guide programmers to design threads of execution that are scheduled to the machine. We depart from this control-centric model to a data-centric program formulation where we express programs as collections of values, called memlets, that are mapped as first-class objects by the compiler and runtime system. Our holistic compiler and runtime system aims to substantially advance the state of the art in parallel computing by combining static and dynamic scheduling of memlets to complex heterogeneous target architectures. We will demonstrate our methods on three challenging real-world applications in scientific computing, data analytics, and graph processing. We strongly believe that, without holistic data-centric programming, the growing complexity and inefficiency of parallel programming will create a scaling wall that will limit our future computational capabilities.

Keywords: high performance computing hpc,exascale computing,parallel programming models,parallel runtime systems
Rydberg dressed quantum many-body systems (RyD-QMB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-06-01
End date: 2021-05-31
Duration (months): 60.0
Total project cost (EUR): 1497374.99
EU funding (EUR): 1497374.99
Participants: 1
Project status: CLOSED

The project “Rydberg dressed quantum many-body systems” (RyD-QMB) will experimentally study long-range interacting atomic quantum many-body systems with tailored microscopic interactions. It will explore supersolidity expected for ultracold bosonic systems with soft-core interactions and realize quantum magnets, that are designable almost at will and feature unprecedented coupling strengths. As such, it opens new directions for atomic quantum simulation and paves the way towards the experimental study and the design of frustrated magnets, interacting topological systems and artificial quantum gauge fields, topics, that not only push the limits of quantum simulators for solid state physics, but also reach out into the field of high energy physics. The unique interaction features RyD-QMB plans to exploit emerge from the combination of ultracold atoms with Rydberg atoms. Using Rydberg dressing long-range interactions will be induced, whose strength, distance dependence and isotropy is controlled. Simultaneously, the gap between the timescales of atomic motion and lifetime of the Rydberg states will be bridged. Strong optical coupling to the Rydberg state is key for the implementation of useful Rydberg dressing. Therefore, RyD-QMB will use high power single photon coupling in the ultraviolet to induce the interactions. RyD-QMB will explore Rydberg dressing of continuous as well as lattice systems and aims to: * Demonstrate microscopic interaction design of quantum many-body systems using strong Rydberg dressing of potassium. * Explore exotic superfluidity in two dimensional long-range interacting systems and, especially, realize soft-core interacting many-body systems that are predicted to show supersolidity. * Study ground states and non-equilibrium dynamics of strongly interacting quantum magnets with designed long-range spin couplings that are induced by the light field.

Keywords: rydberg atoms,quantum many body systems,quantum simulation
Synchronizing Palaeoclimate data for better understanding of the Solar effect on European Climate (SYNC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The sun activity is decreasing since 1996 and a grand solar minimum is expected to occur from 2020 to 2070. The magnitude of solar forcing on the current climate is still uncertain. This project aims to test the existence of quasic-periodic decadal to centennial natural climate variability modulated by grand solar minima during the Late Holocene, which resulted in abrupt climate changes in Europe on time-scale of a few years and has the potential to trigger comparable changes in the future. Describing the timing and the abruptness of the climate response to shifts in the solar activity requires very accurate climate reconstructions and dating, in particular where absolute ages are hampered by the presence of 14C plateaux. This research project will focus on the precise comparison of Late Holocene palaeoclimate records from annually resolved (varved) archives across Europe, with the core goal of estimating the velocity of the climate response to grand solar minima and possible seasonal effects. The project’s novelty lies in the synchronization of very accurate varve chronologies from two European lakes, Diss Mere (England) and Meerfelder Maar (Germany), using tephra layers as synchronous markers. Tephrochronology and varve counting will thus be integrated as a multidisciplinary dating method to minimize the uncertainty derived from individual chronologies (varve counting error). Tephra (volcanic ash) from explosive eruption and atmospheric cosmogenic isotopes s are deposited over large areas synchronously and are reliably correlated to known eruptions. Varved sediments provide accurate chronologies and also store climatic signals at seasonal resolution. The interdisciplinary perspective adopted by this study is designed to tackle gaps in our knowledge of the solar-climate phasing and to provide the most precise proxy data to the climate modelling community. The facilities of Royal Holloway, University of London supports the innovate methodological approach.

Keywords: tephrochronology,varved sediments,late holocene and solar climate phasing
Clinical development of a dendritic-cell vaccine therapy for acute myeloid leukaemia (AML-VACCiN)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Germany,Spain,Germany,Germany,Norway,Finland,Sweden,Romania,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom
Call: New therapies for rare diseases (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2020-09-30
Duration (months): 57.0
Total project cost (EUR): 8278716.25
EU funding (EUR): 6001482.0
Participants: 20
Project status: CLOSED

Eradicating minimal residual disease (MRD) in patients with acute myeloid leukaemia (AML) is an area of high unmet medical need. AML is a deadly rare disease that affects both children and adults. Approximately 45% of younger AML patients who are treated will be cured, and in older patients (>60 years of age), 85% will relapse and die within 2 years. Immunotherapy has great potential for treating MRD and dendritic cell (DC) therapy is at the forefront of immunotherapy. The AML-VACCiN consortium takes this to the next level through clinical development of a highly-innovative DC vaccine - DCP-001 - that can be produced off-the-shelf and has a powerful preclinical and clinical profile. The aim is to vaccinate AML patients that have been brought into remission through standard induction or consolidation therapy, and to eradicate MRD and effectively reduce the risk of relapse. In a clinical Phase I/IIa study, the DCP-001 vaccine has already shown to be safe, non-toxic and capable of inducing an AML-targeted immune response. DCP-001 is designated as an orphan medicinal product in the EU. The AML-VACCiN consortium will advance the clinical development of the vaccine from early-stage (current status) towards proof of concept for safety and efficacy in a Phase IIb clinical study (intended outcome of this project). In addition, a biomarker program will be developed that enables more effective treatment monitoring, selective patient enrolment in future studies and ultimately personalised AML treatment. The deliverables resulting from this project can be used to assemble a data package to apply for conditional approval in Europe. AML-VACCiN is the orchestrated action of three innovative companies and internationally renowned top medical scientists representing nine European medical institutes. In line with the IRDiRC objectives, this public-private consortium can bring a powerful AML-vaccine very close to clinical practice.

Keywords: dendritic cell vaccine,leukaemia,immunotherapy,advanced therapy medicinal product
Eco-efficient decommissioning of wind turbine blades through on-site material shredding and separation (EcoBlade)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Denmark
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-08-01
End date: 2019-07-31
Duration (months): 24.0
Total project cost (EUR): 1992000.0
EU funding (EUR): 1394400.0
Participants: 1
Project status: CLOSED

Wind power plays a crucial role in Europe’s strategy towards a zero-carbon, clean energy-powered economy. While efforts have primarily focused on the development of wind turbine technology, it starts to become evident that the planning associated with the end-of-service life of these installations has been vastly neglected. Wind turbine blades are a particularly challenging component due to their composition and sheer size, which causes uncertainty about how to get rid of them in an environmentally and economically sustainable manner. Frandsen Industri (FI) will tackle this problem through prototyping and testing a mobile separation platform, which shred and separate the blades directly on the wind farms, and have its functionalities and performance documented and validated. This mobile separation platform will meet the need of the wind farm owners and the wind farm manufacturers by solving the existing problems related to decommissioning wind turbine blades, as it will: • Reduce the transportation costs by 16x • Reduce the CO2-emissions by 16x • Enable the wind farm owners to recover the scrap value of €50/ton of their expired blades. As up to 250,000 tons of expired wind turbine blades are to be decommissioned per year in our targeted markets in the 2020-2030 period, the business opportunity amounts to €29M/year. The total CO2-emissions for transporting EOSLWTs blades per year using the current method is 1,540,000 kg. Using our mobile separation platform, the CO2-emissions for transporting EOSLWTs blades will be reduced by a factor of 16x, to 96,250 kg per year. We at FI want to continue our award-winning technological development of solutions within the sphere of decommissioning expired raw materials. The EcoBlade project is a vital part in this, as it allows us to strive for a leadership position in the future market of blade disposal, expecting a cumulated profit of over €10 million in year 5 post project.

Keywords: wind turbine blades,decommissioning,eoslwts blades,mobile separation platform,cutting,shredding,separating,recovery of scrap value,recycling
Conductive, self-doping and biodegradable oligoEDOT-heparin biomaterial for improved electromechanical coupling, cardiac cell retention and delivery of paracrine factors (HepEDOT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Cell therapy has emerged as a promising therapeutic strategy for cardiac repair, showing modest cardiomyocyte protection and infarct size reduction. It is under debate whether these outcomes are due to the implanted cells or their paracrine factors, as cells are scarce within a few weeks post-implantation. Regardless, this is still not sufficient to promote cardiac remuscularization and reverse medium to severe myocardium injury and fibrosis. Improved cell retention has been achieved with a substantial bulk of implanted cells, but highly associated to graft-induced arrhythmia, representing a significant challenge for clinical translation. The present study seeks to promote cardiac remuscularization after infarct, by improving the retention of cardiac cells and their paracrine factors without causing graft-induced arrhythmia. To do so, a conductive, self-doping and biodegradable oligoEDOT-heparin biomaterial will be synthesized and studied on in vitro and in vivo cardiac infarct models. The conductive EDOT oligomer moiety is envisaged to act as an electrical sink to shield the cardiac tissue from mismatched electromechanical impulses, while heparin will facilitate cardiac cell support and loading of regenerative factors, besides its recently documented doping capacity. The results of this fellowship are expected to overcome low cell retention and graft-induced arrhythmia, two of the biggest obstacles for translation in cardiac cell therapy, but also contribute with new insights regarding conductivity in materials and biological systems, to multiple fields of materials chemistry, medicine and bioelectronics. The world-class academic environment, collaborations and combined interdisciplinary expertise in biomaterials and cardiovascular sciences make the proposed fellowship activities ideally placed for enhancing my career prospects and consolidating my host and Europe in a leading position for translational research.

Keywords: conductive biomaterial,cardiac cells,paracrine factors,cardiac infarct,immunomodulation,arrhythmia