Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Bifunctional and regeneratively active biomaterial: Towards an ultimate solution for osteoarthritis treatment (ArthroDUR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-09-01
End date: 2019-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Osteoarthritis (OA) is the most common form of arthritis of the joints, affecting over 70 million EU citizens. At present, no cure for OA is available; only symptomatic therapies may help to ameliorate this painful disorder. OA affects the integrity of the cartilage and progresses to an increased damage in its surrounding tissues, inclusive bone, and to inflammation of the synovial tissue. The latter reaction is caused by an accumulation of bone splinters. The therapy of choice would be – if available – bidirectional: first, regeneration of the damaged cartilage (by implants) and second, dissolution of the bone fragments (by injections). This proposal presents for the first time this two-fold solution. Within my ERC Advanced Grant “BIOSILICA” (No. 268476) we disclosed that biosilica elicits morphogenetic activity in cells involved in connective tissue formation. The effect of silica is augmented by another natural inorganic polymer, by polyphosphate (polyP), which is synthesized in most animal cells, especially blood platelets that accumulate in damaged bone and cartilage. polyP acts as “metabolic fuel” for the synthesis of the extracellular inorganic and organic skeletal and cartilage tissues. Our strategy is to combine and to amplify the beneficial properties of these two polymers, biosilica and polyP, their morphogenetic activity with their structure-forming/guiding activity, by applying hybrid microparticles, consisting of silica and polyP. The proposed project will provide the proof-of-concept of this dual strategy, using silica and the amorphous Mg2+/Ca2+ salt of polyP together with hyaluronic acid, to dissolve firstly existing bone splinters in the synovial fluid (by injection), reducing the painful joint burden in osteoarthritis, and secondly to repair damaged cartilage with polyP/silica implants. This innovative material, injectable and implantable, will be developed to commercializable products for the benefit of the aging society.

Keywords: tissue engineering,cartilage,synovial fluid,osteoarthritis,regenerative medicine,degenerative joint disorder,biomedicine,biomaterials science,regenerative implants,biosilica,polyphosphate
A broad ecological approach to study the biological uptake of dissolved organic matter (DOM) and DOM-flocculates in the rapidly changing Arctic coastal ecosystems (FlocDOM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-01
End date: 2022-02-16
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

The Arctic Ocean receives a vast amount of organic carbon via runoff from surrounding glaciers and thawing permafrost soils. This dissolved organic matter (DOM) comprises one of the world’s largest active carbon pools, i.e. can be respired to CO2 by heterotrophic organisms. Yet our understanding of how well this terrestrial carbon is degraded in the marine environment is poor. As recent climate warming accelerates the input of carbon to the coastal Ocean it becomes more urgent to study this matter as it may play a major part in determining whether the Arctic Ocean becomes a sink or a source of CO2 in the future. In the saltwater-freshwater interface of coastal environments, the salinity change causes the charge of the DOM molecules to change causing about 10-20% of this carbon pool to aggregate/flocculate into larger particles. Bacteria are the main degraders of DOM, however, with flocculation, a great proportion of the carbon becomes available to larger heterotrophic organisms, such as pelagic protists and benthic filter feeders. Via these flocs the carbon enters the food web at a higher level and escapes the microbial loop. This path is however rarely considered. The overall aim of this project is to improve the knowledge on the response of heterotrophic organisms to terrestrial organic carbon supply (both from glaciers and soils) with focus on the coastal ecosystems of Greenland. I will track the degradation paths of both DOM and flocculated DOM using a combination of controlled laboratory studies and field studies using radioisotope tracers. The project ‘FlocDOM’ proposes a much-needed effort for a holistic ecological approach to assess the effects of increased runoff in the Arctic and to quantify for the first time the salt-induced aggregation, subsequent mineralization and burial of various terrestrial DOM pools in the Arctic.

Keywords: carbon cycle,coastal ecology,arctic marine ecosystems,runoff,flocculation,benthic pelagic coupling
Structural Transformation to Attain Responsible BIOSciences (STARBIOS 2)

Framework: Horizon 2020 — Science with and for Society
Programme: Integrate society in science and innovation issues, policies and activities in order to integrate citizens' interests and values and to increase the quality, relevance, social acceptability and sustainability of research and innovation outcomes in various fields of activity from social innovation to areas such as biotechnology and nanotechnology
Action type: Coordination and support actions
Countries involved: Germany,Italy,Italy,Poland,Slovenia,Sweden,Bulgaria,France,United States,Denmark,United Kingdom,Brazil
Call: Supporting structural change in research organisations to promote Responsible Research and Innovation (H2020-ISSI-2015-1, 2015)
Start date: 2016-05-01
End date: 2020-07-31
Duration (months): 51.0
Total project cost (EUR): 3499277.5
EU funding (EUR): 3499277.5
Participants: 13
Project status: CLOSED

STAR BIOS 2 (Structural Transformation to Attain Responsible BIOSciences),coordinated by the University of Tor Vergata (IT), has been designed to respond to the Topic ISSI 5 (Workprogramme Science With And For Society). The general aim of project is that of contributing to the advancement of the Responsible Research and Innovation (RRI) strategy, which underpins Horizon 2020, by promoting 6 Action Plans (APs) oriented to attain a RRI structural change in research institutions from Europe and developing 3 further APs in non-european entities, all active in the field of biosciences. This strategy is geared to cope more in general with one of the main risk, for European research, i.e., its inadequate connection with society, by promoting its increasing alignment, in terms of both process and outcomes, with the needs and values of European society. This entails, in the RRI perspective, an increasing involvement of stakeholders at any level of the research and innovation process. The project has three main focuses: 1) Develop RRI-oriented structural change processes in the already mentioned institutions involved in biosciences research. This aim will be pursued through designing, implementing and evaluating RRI Action Plans. In order to secure the results emerging from the APs, a sustainability strategy will be developed and implemented during the project lifespan. APs will be supported by a central technical assistance and the project will be monitored and assessed. 2) Develop a learning process concerning: a) resistances and barriers to RRI (which are they, how they manifest themselves, which impact they have, etc.); b) key factors favouring or supporting RRI; c) strategic options and RRI-oriented tools. 3) Develop a sustainable model for RRI in biosciences.

Keywords: structural change,research governance,societal engagement,gender,ethics,education,open access,biosciences,scientific citizenship,mutual learning,sustainability,upscaling
Engineering, production and life‐cycle management for the complete construction of large‐length FIBRE‐based SHIPs (FIBRESHIP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Countries involved: Ireland,Italy,Spain,Spain,Cyprus,Greece,Finland,Greece,Romania,France,France,United Kingdom,United Kingdom,Denmark
Call: Development, production and use of high performance and lightweight materials for vessels and equipment (H2020-MG-2016-Two-Stages, 2016)
Start date: 2017-06-01
End date: 2020-05-31
Duration (months): 36.0
Total project cost (EUR): 11041212.5
EU funding (EUR): 8866322.75
Participants: 18
Project status: CLOSED

The main objective of the FIBRESHIP project is to create a new EU-market to build complete large-length ships in FRP (Fibre-Reinforced Polymers) enabling its massive application. In order to achieve this objective, the project will develop, identify and qualify FRP materials for different applications in particular for long-term structural strength and fire resistance. In addition to this, its massive application also requires elaborating innovative design procedures and guidelines supported on new validated software analysis tools. Standardized efficient production methodologies will be implemented and demonstrated by delivering a proof of concept. Clear performance indicators will be designed and applied in the evaluation of three targeted vessels categories (container ship, ferry and fishing research vessel) to be developed within the project. The project will also analyze the life cycle cost benefits of incorporating FRP materials in large-length ships, developing a business plan for the different actors in the value chain. The business plan will cover the different phases of the life cycle from design, engineering, material production and shipbuilding to the final dismantling of the vessel. The use of FRP materials in large-length ships will imply a significant weight reduction (about 30%) and a relevant impact in fuel saving, ship stability, environmental impact (reducing greenhouse gas emissions and underwater noise), and increase of cargo capacity. On the other hand, FRP materials are immune to corrosion and have a better performance under fatigue type loads, what means better life performance and reduced maintenance costs. The mid-term impact is estimated in about 5% of the total shipbuilding market in Europe (turnover about €2.0Bn), and it is envisaged a long term impact of up to 54.000 new direct jobs. Furthermore, it is estimated that the European shipping companies could deduct up to €1Bn/year cost with the adoption of the proposed FRP shipbuilding technology.

Keywords: complete large length frp ships,design and production guidelines,adapted software tool,inspection methodologies,full scale demonstrators,fuel saving,environmental impact abatement,business opportunities
The premium green multi-cloud management and optimization tool (NUVEA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: France
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Feasibility study - NUVEA is carried out by the SME New Generation SR, an innovative start-up active in the field of digital technologies and infrastructures. The objective of the overall project is to bring to customers an on-line platform that allows them to take over, manage, benchmark and optimize permanently their distributed IT infrastructure (at the web- and entreprise-grade), independently from the underlying cloud resource provider(s), in a highly flexible and real-time manner. NUVEA targets cloud computing stakeholders: data center managers, cloud suppliers, big companies with significant in-house IT infrastructures willing to optimize their energy consumption and average server load; public institutions wanting to have fully sovereign or close-to-territory IT infrastructure; and companies having a part of their core competencies cloud-hosted, or significant IT expenditures. A first version of the algorithm and interface was developed and successfully tested in a laboratory environment. The present feasibility study aims at assessing technical and economical characterics of NUVEA’s value proposition through alpha tests on early adopters and in depth market study. This work will enable: - The release of the first commercial version of NUVEA software (validated on “early adopters”), - The definition of technical specifications required for the further development of NUVEA on-line platform (NUVEA platform) - The elaboration of a detailed business-plan based on operational experience, - The identification of the preferred stakeholders for european deployment of the solution, - An updated project executive summary ready for the search of new equity. Phase 1 will help to finance scientific support and marketing expert required for the feasibility study Later on, Phase 2 would perfectly allow to finance further development plan (from commercial software to web-based NUVEA platform).

Keywords: cloud computing,green it,brokerage
Brain injury in the premature born infant: stem cell regeneration research network (PREMSTEM)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Australia,Germany,Spain,Italy,Italy,Switzerland,Sweden,France,France,Netherlands,Netherlands,Netherlands
Call: Regenerative medicine: from new insights to new applications (H2020-SC1-2019-Single-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 10708285.0
EU funding (EUR): 8999620.0
Participants: 16
Project status: SIGNED

This project will provide new knowledge regarding the best regimen, timing, dose, and route of administration of human mesenchymal stem cells (H-MSC) for regenerating the brain damage in infants born preterm; born before 37 of a typical 40 weeks of gestation. Over 15 million babies are born preterm every year it is a leading cause of death and permanent disability, often due to brain damage. The H-MSC that we will comprehensively screen are FDA-approved and in the process of being produced in a GMP grade, making them suitable for future clinical trials in human preterm born infants. These H-MSC will be evaluated in a large number of rodent models mimicking the key insults and brain damage observed in human preterm infants who will develop later motor, cognitive, and behavioral deficits. We will also apply theseH-MSC in two sheep models of injury relevant to brain damage associated with preterm birth. These large animal trials are a key step before initiating clinical trials in this high risk human population. Additional Workpackages will address the mechanisms underlying the regenerative effects of these H-MSC. This project addresses the call text by value adding to current knowledge of stem cell types and applying it to a large patient group with an unmet clinical need – infants with encephalopathy of the preterm born infant. Steps on the innovation chain targeted – preclinical research, proof of concept and to a lesser degree characterization of regenerative mechanisms.

Keywords: stem cell therapy,preterm birth,encephalopathy,neuroprotection
PATRIMONiT. From Cheap Print to Rare Ephemera: 16th-Century Italian 'Popular' Books at the British Library (PATRIMONiT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-02-01
End date: 2018-01-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Large quantities of 16th-Century Italian ‘popular’ books – the books read or ‘listened to’ by everyone during the Early Modern Period, printed with poor quality material and having usually a short life expectancy –, sometime after the 16th century found their way to the UK to join the largest single collection of Italian 16th-century books in the world, that is the British Library (BL). This library preserves today a substantial number of early Italian editions which do not survive in any Italian library and are still not adequately recorded. The objectives of the PATRIMONiT project are both bibliographical and historical: 1) to survey all the 16th Italian ‘popular’ books now at the BL which do not survive in any Italian library; 2) to define new rules for cataloguing 16th ‘popular’ books and catalogue approx. 250 items in the PATRIMONiT database, entering the data in EDIT16 and in the CERL Thesaurus; 3) to study the edition history of these books using archival sources, that is to examine the historical circumstances related to their survival and international circulation with a new methodology. Carnelos proposes to demonstrate that this ephemeral material is really important in reconstructing the socio-cultural history of a country. Specifically, her aim is to understand when and why ‘popular’ books underwent a change in their perceived value, from books to be used and reused to books that were considered at once disposable and worthy of collection, and how time and space, politics and cultural policies influenced this change. Supported by three centres of excellence (the Consortium of European Research Libraries or CERL, the BL and the Istituto Centrale per il catalogo unico delle biblioteche italiane e per le informazioni bibliografiche or ICCU), the PATRIMONiT project combines the more recent developments in three main disciplines (Library Science, History and ICT), to tackle historical questions which cannot be approached and successfully solved individually.

Keywords: early italian books chapbooks cheap print history of the book history of libraries history of early printing ephemera british library collections 16th century popular culture book trade
Polygon scanner based ultra-short pulse laser processing in roll-to-roll manufacturing (PoLaRoll)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Germany,Italy,Germany,Germany,Belgium,Belgium,France
Call: Photonics Laser-based production (H2020-FOF-2016, 2016)
Start date: 2016-10-01
End date: 2020-01-31
Duration (months): 40.0
Total project cost (EUR): 4339466.25
EU funding (EUR): 3508527.75
Participants: 7
Project status: CLOSED

Roll-to-roll manufacturing is well established in many segments like electronics, micro manufacturing or solar technology. Continuous roll-to-roll manufacturing processes can be integrated with various manufacturing steps within the production line. While many conventional and laser manufacturing techniques could already be embedded successfully into roll-to-roll machines, pulsed laser structuring could not be adapted sufficiently. The main obstacles are insufficient pulse repetition rate levels with required pulse energy and beam deflection speed and accuracy. The PoLaRoll project aim is to bring together current developments and fully integrate a high speed ultra-short pulse laser ablation process into a roll-to-roll machine fulfilling the requirements of individualised laser-based mass production. Various disciplines are in focus of the PoLaRoll project: A femtosecond laser will be developed with high pulse energy at extremely high pulse rates. Innovative polygon scanner technology for ultra-fast beam deflection is advanced in speed and accuracy and a dual polygon scanner will be developed enabling simultaneous laser structuring of top and bottom face of web material. An in-line metrology method will be developed enabling process monitoring and control. Highly sophisticated methods will be developed and applied enabling the synchronisation of the ground-breaking ultra-fast processing sub-systems. To prove the PoLaRoll process performance a target application has been selected, which is solar shading of glass facades. The laser formed micro structure's geometry allows cutting the solar radiation and therefore reduces the energy used for cooling and ventilation. The PoLaRoll laser structuring module will be integrated into a prototypical modular designed roll-to-roll machine as well as in a conventional machine for mass production operated by the industrial end-user. Thus the PoLaRoll project will be able to revolutionise the current state of the art in digital roll-to-roll processing.

Keywords: individualised laser structuring,laser integration,ultra short pulse laser,femtosecond laser,in line metrology,process automation,digital production,roll to roll process
Management of Municipal Water Waste Treatment Plants Potential by-Products of Sewage Sludge Ash type, as Active or non-Active Additions to Portland Cement-based Binders (Sewage Sludge in PC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Poland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 134462.4
EU funding (EUR): 134462.4
Participants: 1
Project status: CLOSED

The main objective of the proposal is to design a flow chart for the valorisation process of sewage sludge (SS) waste stream from municipal water treatment plant origin, (code 19 08 05, in accord with 2014/955/EU Decision), and its subsequent use as supplementary cementitious material (SCM). The End-of-Waste (EoW) criteria is applied, in the first stage, by assessing of the potential organic and inorganic hazardous constituents content and manner of their removal or inertization (by optimized incineration process, mainly). Secondly, in order to generate a final SS ash (SSA) by-product of constant physical-chemical properties, apt to be used as a SCM, an adequate analysis of its main chemical components (SiO2, Al2O3, Fe2O3) is provided, according to EN and ASTM requirements and testing to quality standards, with a special consideration of eventual pozzolanic activity. Once the classification of thus obtained SCM is carried out as active or non-active addition, its performance in the Portland cement (PC) based binders is studied. The manufacturing of new PC/SSA cements and its resultant products, concretes and mortars, is focused from the following principle perspectives: mechanical compressive and flexural strength efficiency, volume soundness and chemical durability in front of chemical aggressive media like sulfates, chlorides, sea water action, etc. Finally, an impact assessment of the proposed EoW procedure is evaluated taking into account its legal, economic, market, social and environmental aspects. The current proposal seeks to address regional work programme of sustainable energy development in Central Poland by putting forward an idea of the local residual materials management, once converted into by-products, to manufacture concretes and mortars in the same conditions and with identical constructive uses that PC ordinary concretes and mortars, nowadays, dictated by environmental and economic questions, principally, in the most of industrialized EU countries.

Keywords: sewage sludge ash,portland cement,by products