Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Memory and innate-like B-cell subsets: deciphering a multi-layered B-cell response in mice and humans (B-response)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: France
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2021-08-31
Duration (months): 60.0
Total project cost (EUR): 2098750.0
EU funding (EUR): 2098750.0
Participants: 1
Project status: CLOSED

B cells are the main actors of successful vaccines, and their protective capacity relies on several subsets with innate-like and memory properties that fulfill different effector functions. In the present project, we wish to develop approaches in both mice and humans, to confront the similarities and the differences of their B cell responses. The three aims proposed are: 1) To study the different B cell subsets and TFH cells engaged in a memory response through the use of a new mouse reporter line allowing their irreversible labeling (inducible Cre recombinase under the control of the Bcl6 gene): this will be performed in different conditions of TH1 vs. TH2 polarization, as well as during a chronic viral infection, in which virus-specific antibodies have been shown to be required to control the disease (in collaboration with D. Pinschewer, Basel) 2) To study whether the lifelong persistence of B cell memory, as occurs for memory B cells against smallpox that we can obtain at high purity from aged donor's spleens, corresponds to a specific transcriptional program at the miRNA, lncRNA or mRNA level, as well as a specific cell homeostasis 3) To discriminate the specific effector function of human marginal zone and IgM memory B cells in, respectively, T-independent and T-dependent responses, as well as their specific differentiation/diversification pathway. The general goal is to delineate the regulatory pathways leading to the activation and persistence of the different B cell subsets, allowing for a better understanding of the conditions leading to their pathological or beneficial mobilization.
Integrated Mobile Platform for Activity Commoditisation in the Travel market (IMPACT) (IMPACT)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: United Kingdom
Call: SME business model innovation (H2020-SMEINST-1-2015, 2015)
Start date: 2015-10-01
End date: 2016-01-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

• Market issue: EU tourism and travel sector (worth €300Bn and employing 9.7M people) faces new challenges to growth (incl. digitisation and diversification) that prevent SME growth: 1) Excessive fragmentation: high diversification (>30 verticals) and hyperlocal nature of the market prevent scalability and innovation (PCWI, 2014). 2) Digital divide: 90% travellers research holidays online (FairFX, 2012), but only 12% of providers have digital reservation systems, skewing demand (PwC, 2014). 3) Price inflation: SME providers are forced to rely on high and overlapping referrals for customer acquisition, causing price inflation (Rezdi, 2015). The challenges are particularly acute for the guided tour segment, worth €7bn p.a. • Proposed solution: Touriocity has proven the concept of an Integrated Mobile Platform for Activity Commoditisation in the Travel market (IMPACT) to improve digital accesss for the long-tail of guided tour providers. IMPACT fits objectives of the Business Model Innovation work programme by supporting growth and innovation of 1.8M tour operators (81% have turnover <€1M p.a., 33% <€250k p.a), helping them to gain a growing share of the fast-growing bespoke guided tour segment (40% share) and creating a level-playing field with more established competitors. • Why funding is needed: Touriocity has tested IMPACT technology with 6k students in London, and has secured pilot trials with a further 250k registered users in 20 locations – in partnership with Gatwick Airport. Support from SME Instrument Phase 1 will be critical to prove technical feasibility and commercial viability of IMPACT in EU28, adapting the prototype to fit local market needs. Successful commercialisation of IMPACT in EU28 will help resolve market biases generated by unequal access to digital tools, helping SMEs to tap into the €7Bn guided tour sector, and disrupting the last segment of the travel market to be commoditised.

Keywords: guided tour,activities,commoditisation,travel,visitor,tour guide,fragmentation,diversity,platform,client management,disruptive technology,innovative ict,sme improvement
STRATEGIC PLANNING FOR WATER RESOURCES AND IMPLEMENTATION OF NOVEL BIOTECHNICAL TREATMENT SOLUTIONS AND GOOD PRACTICES (SPRING)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Protection of the environment, sustainable management of natural resources, water , biodiversity and ecosystems
Action type: Research and Innovation actions
Countries involved: India,Finland,Hungary,Norway,Norway,Portugal
Call: EU-India water co-operation (H2020-SC5-2018-1, 2018)
Start date: 2019-08-01
End date: 2024-07-31
Duration (months): 60.0
Total project cost (EUR): 3116948.75
EU funding (EUR): 3116948.75
Participants: 14
Project status: SIGNED

The overall aim of the SPRING project is to present an integrated water resource management for reliable water supply for all needs that involve; developing innovative simple to operate bio oxidation systems for treatment of polluted water bodies (stagnant and flowing), cost effective real time monitoring tools and finally by implementing good practices in water planning for treatment, supply and usage. SPRING aims at improving and developing technologies for the elimination of pollutants from water using a bioremediation approach. In particular, SPRING aims at improving and developing bioremediation technologies for the removal of organic micro-pollutants present in groundwater and surface water at low concentrations, and which are currently treated using expensive physicochemical technology. Innovation also revolves around provision of simplified water quality monitoring methods and developing novel microbial technology to monitor pollutants in water. The Project will also develop real time detection systems to highlight different pollutants risks and flooding/water insufficiency scenarios. Field trials of the developed prototype in urban and rural settings will be carried out with the help of Municipality and an NGO. In addition, an inclusive decision-making process will contribute to democracy and will lend the decision legitimacy. Acceptance of remediation schemes during implementation will be enhanced by involving stakeholders and the public in the decision-making stage and thus, stakeholders decision making and management framework in the form of an NGO and a local Governing Body (Municipality) will be formed. Successful implementation and demonstration of the developed systems involving all stakeholders will help to achieve wide public acceptance towards reuse and recycling of wastewater through the developed bioremediation technology

Keywords: microbial sensors,real time monitoring,remote sensing
Early roots of lying in families (FAMI-LIES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-11-01
End date: 2026-10-31
Duration (months): 60.0
Total project cost (EUR): 1498250.0
EU funding (EUR): 1498250.0
Participants: 1
Project status: SIGNED

Children who lie, learn this from a very young age. While some forms of lying are harmless, or even adaptive, other types are maladaptive. Yet, social origins of lying are grossly understudied. Parents sometimes lie (claiming to leave the child behind, when misbehaving) or model lying to children (telling someone they love a gift, while admitting to the child their dislike). How parental deception affects children is unknown. In fact, socialization of child lying is paradoxical: despite lying or modelling lying, parents usually teach that lying is wrong. Thus, many children receive mixed messages about the value of honesty. To begin the crucial study of this paradox, I coin a novel term: “parental moral dissonance”, a mismatch between what parents teach about lying and what they actually do. In the multimethod FAMI-LIES project, I will explore and explain how and why parents lie to children, how this contrasts with what they teach, and how lying and moral dissonance relate to child socio-emotional and moral outcomes. The problematic scarcity of research on social origins of lying reflects in a lack of valid measures to assess variation in parental lies. Therefore, I will first design a new, necessary questionnaire and behavioural observation codes to assess parental lying. Second, I will explore parental and child correlates of moral dissonance to generate hypotheses about its appearance, origins, and effects. Third, I will assess longitudinal associations (including bidirectional patterns) between parent and child lying, and child outcomes. Fourth, I will experimentally test causal socialization pathways from parent to child lying. A unique integration of insights of psychology and family studies frames lying in a psychosocial context. Findings will impact various disciplines, aid evidence-based prevention and intervention programs for parents and children, and provide foundations for further expansion of this societal and clinically relevant research line.

Keywords: parental lying,child lying,parental socialization,child socio emotional development,behavioural observations
Synthesis of Low Noise Microwaves Using Solitons Locked to an Ultra-Stable Cavity (SOLISYNTH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

This project (SOLISYNTH) aims to utilize the novel crystalline microresonator optical frequency comb to synthesize ultra-stable microwaves. The microresonator comb will operate in the state of temporal dissipative soliton and an ultra-stable Fabry-Perot cavity will be used as a reference for the comb to lock to. By using direct optical division with the comb, this work could offer a new approach to synthesize low-phase-noise microwaves in a compact form factor, which could have applications in Radar, timing and telecommunications to radio astronomy. In addition, this project seeks to generate mid-infrared soliton comb with octave spanning bandwidth through dispersion engineering and quantum cascade laser pumping. With its exceptionally high coherence, such frequency comb offers access to the molecular fingerprinting region where many chemical species show distinctive absorption features. Devices based on this research output can find tremendous applications in mining, agriculture and medical diagnosis. Due to the prominent values of the research on microresonator comb, there are many groups in the US delved into this field, and the numbers of publications and filed patents on this topic has been rising rapidly. Hence this project will not only enhance Europe’s position in scientific competition with US, but also gain substantial economic benefits through strengthened industrial innovation. On the other hand, the host group in EPFL will consolidate its leading position in the field by integrating the applicant’s knowledge and experience on ultra-stable cavities and laser stabilization with the soliton comb research, thus facilitating both the fundamental investigation and the commercial development based on the microresonator frequency comb. Moreover, the applicant will acquire both research competencies and managerial and leadership skills, which will serve as the foundation of undertaking independent research and leading scientific and technological developments.

Keywords: microresonator,optical frequency comb,microwave,soliton
An Investigation into the viability of employing lipoaspirate fluid as a cellular source in the production of small diameter tissue engineered vascular grafts (LAF-GRAFT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 248063.4
EU funding (EUR): 248063.4
Participants: 2
Project status: CLOSED

Tissue engineered vascular grafts (TEVGs) hold great promise in the field of regenerative medicine and also possess the true potential to revolutionise the way in which clinicians treat the growing burden of cardiovascular disease. Treatment is achieved by incorporating an appropriate cell source onto a biodegradable scaffold and implanting the graft to bypass non-patent vascular segments. However, numerous issues regarding TEVG cell source render the technique unviable in a clinical setting as the cells require high levels of manipulation including digestion, isolation and culture. These issues increase processing costs, decrease cell stability and raise numerous regulatory issues. The use of minimally manipulated liposuction aspirate fluid (LAF) may offer a safer and more efficient cellular source in regenerative TEVGs. However, the capacity of LAF to act as a viable cell source for TEVGs is untested. The aim of this pr oject is to determine the capacity of LAF derived cells to act as a viable cell source for TEVGs. This will be achieved through characterisation of the LAF cells, investigation of the environment that best promotes favourable cellular behaviour, an in vivo study on the viability of the graft to act as a vascular interposition in a small animal model, scaling of the graft to appropriate human size and finally an in vivo study of the grafts ability to function as a vascular bypass in a large animal model. This fellowship will have an outgoing phase to Prof David Vorp’s Lab at the University of Pittsburgh and a return phase to Prof Fergal O’Brien’s Lab at the Royal College of Surgeons in Ireland. Having recently completed my PhD, which focused on the mechanical and morphological characterisation of human diseased vascular tissue, this fellowship will allow me to expand my existing repertoire of research and complementary skills to consolidate and build upon what I have learned to date as I evolve my independent, professional research career.

Keywords: tissue engineering,small diameter vascular bypass,liposuction aspirate fluid
Novel Functionality of Magnetic Shape Memory Alloys by Magnetic Hysteresis Control (FUNMAH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Czechia
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 154720.8
EU funding (EUR): 154720.8
Participants: 1
Project status: CLOSED

Magnetic shape memory alloys (MSMAs) are smart materials which exhibit large shape changes in magnetic field. Novel functionalities of MSMAs, such as mechanically-induced demagnetization, originating from the enlarged magnetic hysteresis (MAH), have recently been introduced by the fellow. The finding opens a new topic in the field and extends significantly the application potential of MSMAs. Large scientific and commercial impact is expected if the research is further pursued. The objective of this project is to build comprehensive understanding of the novel functionalities of MSMAs resulting from the enlarged MAH and to confirm them experimentally. First, we will identify the causes of enlarged MAH in Ni-Mn-Ga-(B) alloys and explain the physical mechanisms underlying the novel functionalities. The acquired knowledge will be used to produce new MSMAs with strengthened novel functionalities. These new alloys will be characterized and used in demo applications built within the project to explain and merchandise the advantages of novel functionalities to industrial community and general public. The project outputs will advance the fields of magnetism, martensite, and MSMAs by explaining the novel functionality paradigm based on interaction of hard ferromagnetic and ferroelastic microstructures. The outputs will be also of practical value, shifting the MSMAs towards new types of practical applications. The Host Institute will enable the fellow an access to unique instrumentation and expertise in magnetism and alloy production while simultaneously will integrate the fellow as a senior researcher. In return, the fellow will bring his unique combined industrial and academic experience in the field of MSMAs as well as new collaborators from Finland, Poland, Germany, and USA. The project boosts the fellow's research skills in experimental physics and initiates his independent research career in the Czech Republic.

Keywords: magnetic shape memory,magnetic hysteresis,mechanical hysteresis,martensite,functional,material
In-wheel electric drive for E-commercial vehicles (GEM E-drive)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Slovenia
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2015-01-01
End date: 2015-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The main goal of the innovation project is to develop a new electric drive inside the wheel for mobility market of electric buses and electric transport vehicles (E-commercial vehicles). The classical conceptual solution with electric motor positioned at the place of combustion engine has several drawbacks: heavy weight since mechanical transmission is needed, complex solution with many moving parts, low efficiency because of transmission losses and need for extra place. With our new solution that is simple (direct drive with no mechanical transmission), efficient (up to 92%), light (lighter up to 50%) and cost effective (simple production) we want to enhance the usage of electric drive for city traffic (buses and vans). In addition, our developed technology is easy adaptable for different applications and power levels due to its unique modular concept. Therefore our new electric drive solution together with low driving cost using electric energy and with reducing pollution, noise and C02 emission in cities and urban areas, especially in Low Emission Zones (LEZ), represent excellent business opportunity for emerging E-mobility market of commercial vehicles and thus also realizing a company vision to become an important European in-wheel drive producer. For the realization of the project a feasibility study is required with delivered elaborated business plan as an outcome with following objectives: • technical feasibility study of in-wheel electric drive development for 25kW power and customization to other applications – modular concept • impact study of regulations and homologation on the product development • market analysis and detailed customer requirements study • strategy definition for entering to the market and product development • analysis of manufacturing process and cost evaluation with optimal process definition • risk evaluation with measures for risk minimization • identify strategy for IP management with timeline

Keywords: electric drive,in wheel electric motor,hub motor,electric powertrain,e commercial vehicles,e mobility
Rethinking China’s Model of Urban Governance (ChinaUrban)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 2492786.0
EU funding (EUR): 2492786.0
Participants: 1
Project status: SIGNED

China’s phenomenal urbanisation is of world-historical significance and imposes profound theoretical and policy challenges. This ground-breaking project will rethink China’s model of urban governance through grounded and multi-scalar investigations ranging from neighbourhoods and cities to regions. For neighbourhoods, it unravels the interface between state and society in everyday living space, migrant social agencies and the self-governance of homeowners’ associations under urbanisation and housing marketization. For cities, it interrogates the development strategies and governance of migrant and ecological urbanism as well as the implementation of projects through financial instruments and the land market. For regions, it uncovers entangled state–market relations which redistribute population and economic activities across cities and produce the city-region. The research will be conducted through six cases: Shanghai, Wuhan, Dali, Xiongan, Jing-Jin-Ji (Beijing-Tianjin-Hebei), and the Guangdong–Hong Kong–Macau Greater Bay Area, based upon grounded ethnographic observations, in-depth interviews and close engagement with Chinese researchers and policy makers across different types of neighbourhoods and cities of varying sizes in coastal, central and western regions, and recent national strategic projects. The project is timely for China to implement a UN-endorsed new urban agenda and rethink its model in the face of trade tensions. It will change how we think of China and its governance and be the first of its kind to explicitly consider indigenous perspectives on Chinese urban transformation. This innovative and contextually sensitive research will contribute to entrepreneurial urban governance theories and will offer a theoretically nuanced and grounded explanation of state entrepreneurialism in China, with six workshops organised within China as integral parts of knowledge production as well as a series of publication outputs.

Keywords: chinese cities,urban china,urban governance,neighbourhood,city region,rural migrants