Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SPEctrally Resolved Action PHOtocurrent Ultrafast Spectroscopy (SPERAPHOUS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 2
Project status: SIGNED

With the rise in global warming, transitioning to renewable energy is more necessary than ever. Organic solar cells (OSC), with their flexibility and lower production costs and footprint, offer promising platforms for efficient light harvesting and net zero greenhouse gas emission. While OSCs nowadays depict 20% power conversion efficiencies, their performance is hindered by the bound states leading to photocurrent losses as they cannot provide free charge carriers. Efforts have been made to understand these bound states such as bound excitons, bound charge transfer states, and localized polarons as mitigating them could boost efficiency. However, identifying and analysing their dynamics requires extensive experimental work involving various techniques, mathematical tools, and modelling, further complicated by linking experimental results to device performance. Herein, by combining my expertise in photocurrent spectroscopy on optoelectronic devices under operando conditions with the host’s expertise in ultrafast multidimensional spectroscopy, I propose the SPEctrally Resolved Action PHOtocurrent Ultrafast Spectroscopy (SPERAPHOUS). This will spectro-temporally characterize bound states in OSCs under operando conditions ultimately leading to the development of design rules to improve OSCs efficiency. To achieve this, an interferometric system combined with ultrafast pulses, providing the spectro-temporal information, will be applied on Non-Fullerene Acceptor (NFA): Donor OSCs whose photocurrent response will be measured. SPERAPHOUS will contribute to the OSC research community and pave the way for investigating other optoelectronic devices, such as those based on perovskites and two-dimensional materials. Furthermore, through SPERAPHOUS, I will gain new knowledge and skills in ultrafast multidimensional spectroscopy, and I will enhance my academic skills broadening my scientific background leading to research independence.

Keywords: organic solar cells,non fullerene acceptors,action spectroscopy,two dimensional spectroscopy,ultrafast spectroscopy,excitons,charge transfer state,photocurrent
Lepton Symmetry Experiment – matter / antimatter symmetry test with electron and positron (LSYM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 2458045.94
EU funding (EUR): 2458045.94
Participants: 1
Project status: SIGNED

In modern physics we are faced with the unsatisfactory situation that the Standard Model (SM), which condenses our current state of knowledge in the form of quantum field theories, despite its spectacular success in the prediction of laboratory results, fails in explaining even the most basic properties of our Universe, such as the disparity of matter and antimatter and the possible existence of dark matter. In the quest to search for answers to these questions, low energy, high precision experiments in ion traps have taken a pivotal role by allowing precise tests of the charge, parity and time (CPT) reversal symmetry. I propose an ambitious, next-generation Penning-trap experiment that will enable us to directly compare the magnetic moments of electron and positron at 14 digits precision. To this end, we will simultaneously trap a single positron and an electron in the same trap and directly compare their spin precession frequencies. To enable the co-trapping of the oppositely charged particle and antiparticle, we will bind the electron in a hydrogenlike 4He+ ion. As a result of the binding, the spins of both particles show a slow beat, which can be accurately measured. Any deviation of this beat frequency from the prediction by quantum electrodynamics (QED) reveals a CPT violation. This way, LSYM will enable a uniquely sensitive comparison of particle and antiparticle charge, mass and g-factors and thus yield the most stringent CPT test in the lepton sector. To this end, we will develop a novel, superconducting Penning trap apparatus, which can be cooled to millikelvin temperatures to largely eliminate black-body radiation. Building upon techniques recently pioneered by my group, LSYM will allow the coherent “quantum” measurement of the difference of the spin precession frequencies. Furthermore, with this toolbox at hand, we will have access to a new class of intriguing measurements, such as an order of magnitude improved determination of the electron atomic mass.

Keywords: penning trap,precision physics,g factor,electrons,cpt,antimatter,qed
European Partnership on Innovative SMEs (InnovativeSMEs)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Partnership on Innovative SMEs
Destination: European Partnership on Innovative SMEs
Action type: COFUND actions
Partnership: Innovative SMEs (co-funded)
Countries involved: Belgium,Austria,Portugal,Spain,Germany,Sweden,Italy,Latvia,Poland,Finland,Hungary,Croatia,Türkiye,Denmark,Norway,Estonia,Netherlands,Malta,France,Ireland,Cyprus,Israel,Luxembourg,Bulgaria,Czechia,Iceland,Lithuania,Romania,Greece,South Africa,Slovakia,Slovenia,United Kingdom,Switzerland,Korea, Republic of,Singapore,Canada
Call: European Partnership on Innovative SMEs (HORIZON-EIE-2025-01, 2025)
Duration (months): 90.0
Total project cost (EUR): 428874646.5
EU funding (EUR): 108000000.0
Participants: 44
Project status: CLOSED

The European Partnership on Innovative SMEs (InnovSMEs) is a strategic initiative aimed at strengthening the global competitiveness of innovative small and medium-sized enterprises (SMEs) through international collaboration in research, development, and innovation (R&D&I). Uniting 43 national and regional funding authorities from 37 countries, the Partnership extends beyond EU Member States and Horizon Europe Associated Countries, representing a unique force in Europe’s innovation ecosystem. InnovSMEs is guided by a clear vision and mission: Vision: To drive economic growth and job creation by empowering innovative SMEs, while fostering positive societal and environmental outcomes across Europe and beyond. Mission: To support SMEs in developing and commercialising products, services, and processes by funding market-oriented, international collaborative R&D&I projects and connecting them with enabling measures. To realise this vision, the Partnership pursues three overarching objectives: 1. To enable SMEs to provide all forms of innovation, including breakthrough innovation, and strengthen market deployment of innovative solutions. a. Facilitate SME’s capacity of innovate and commercialise b. Increase employment and turnover c. Increase access to innovation finance d. Promote sustainable economic and societal impact 2. Foster the internationalisation of innovative SMEs. a. Improve access to global knowledge and high-quality collaboration b. Become the steppingstone to international R&D&I partnerships c. Improve access to new markets and value chains 3. Connect Member State programmes to unlock the collective potential to strengthen the EU innovation capacity of SMEs and spread the benefits within a stronger ERA. a. Link to other national, regional, European and Eureka support schemes b. Achieve balanced participation of consortium members, with special focus on widening countries. These efforts aim to put Europe’s SMEs at the forefront of global innovation.
Quantum interfaces with single molecules (QUINTESSEnCE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1999993.0
EU funding (EUR): 1999993.0
Participants: 3
Project status: SIGNED

Isolating and addressing individual quantum systems has allowed for breakthrough results in quantum mechanics. Today, increasing the complexity of the system while maintaining control at the single-quantum level is vital for the next generation of quantum devices and research. QUINTESSEnCE will take up this challenge by developing interfaces between single photons, spins and phonons, all within one simple physical system, i.e. a single molecule. Fundamental systems like molecules have the inherent advantage, in comparison to artificial structures, of being nominally identical. A molecule can have the coherence properties of an atom even when embedded in a solid, without losing the access and customization opportunities typical instead of the solid state. Molecules differ from atoms in being more complex systems, with rich energy diagrams structured over multiple scales. We propose to leverage this complexity to coherently connect optical frequency photons with microwave spin excitations and gigahertz phonons. Unprecedented control over the molecules’ degrees of freedom will be achieved by integrating them in nanostructured devices. We will develop a ground-breaking lab-in-a-molecule platform, benefiting from the tunability and scalability of molecules, so as to aim at the following main objectives: • Complex states of light: integrating multiple molecular sources of indistinguishable photons on chip • Single-molecule cavity optomechanics: accessing the regime of single-photon strong coupling in an unconventional cavity optomechanical system • Optical addressing of single molecular spins: providing a crucial knob to read out and control the spin state of a single molecule QUINTESSEnCE will therefore allow us to entering unexplored quantum territories and to develop quantum-technology tools unavailable today. Notably, the outcome of this project will impact a broad scientific community, touching quantum optics, optomechanics and molecular quantum technologies.

Keywords: single molecule physics quantum emitters interfaces hybrid systems
Learnings for European Autonomy to Deliver Europe's Rail in 2030 (LEADER 2030)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Europe's Rail
Action type: Research and Innovation actions
Partnership: EU-RAIL (JU-JTI)
Countries involved: Belgium,Germany,France,Türkiye
Call: European value chains for rail supply (HORIZON-ER-JU-2022-02, 2022)
Start date: 2023-07-01
End date: 2026-03-31
Duration (months): 33.0
Total project cost (EUR): 718910.69
EU funding (EUR): 700032.12
Participants: 4
Project status: SIGNED

The LEADER 2030 objectives are: (1) Understanding (a) what has already proven to be vulnerable in the EU industrial ecosystems in general (given cross-sectorial problems), and in the EU Rail supply chain (OEMs and 1-3 Tiers) and Raw materials supply chain in detail; (b) what the ERJU-driven innovations for 2030 will look like in terms of components and raw materials (detail from OEMs to 1-3 Tiers level); (c) what the European supply capacity of such components and raw materials will look like; (d) what elements will impact on such supply capacity (enablers, obstacles); (e) how enablers can be further boosted and how obstacles can be fixed/mitigated to foster autonomy and resilience; (f) what will go out from the Rail supply chain in terms of demand in 2030, and (i) if this can be used to free-up components and raw materials useful to the new innovations (ii) how to support the reconversion (total/partial) of affected companies; (g) how to get the Rail supply industry – with specific attention to SMEs and start-ups – ready for 2030 demand; (2) Proposing/Recommending policy-level actions and industrial-level actions as result of all the intelligence analysis made in the project. The ultimate goal of the project is in fact to assess and increase the European Rail Supply Industry capacity to deliver the European vision of a radically transformed railway system in 2030, and thanks to this, to remain global leader. To achieve this, LEADER 2030 has developed a very holistic approach and methodology thanks to a very strong and complementary partnership joining all the necessary competences from the Rail, Raw Materials and Innovation sectors, and strategically open to synergies with other relevant organisations in Europe that already support the project with their LoS (10). The key call's request to ensure coverage of the Rail Supply SMEs and start-up is ensured by the Coordinator, as European Meta-cluster of the Rail Supply Chain with 2.000 companies, of which >1.500 SMEs.

Keywords: industrial ecosystems,clusters,value chain,smes,autonomy,supplies disruption,resilience,global competitiveness,geopolitics,risk mitigation,industrial alliances,circular economy
Mechanisms and consequences of cell state transitions during heart regeneration (HEART_STATES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Organs consist of cells with a large diversity of specialized roles. A fundamental question is how these cells mount a coordinated response in space and time to maintain or restore organ function after perturbation. Recent progress in single-cell genomics has generated the opportunity to understand this process on a system-wide scale. We will use the adult zebrafish heart as a powerful model system to dissect how regeneration after injury is orchestrated by the activation response of multiple different cell types. To understand how activated cell states are generated and how they interact to drive the regenerative process, we will: 1) Define which cell types react to injury and measure their activation profiles. We will develop new experimental and computational strategies for measuring cell states, including a “molecular time machine” that records the past transcriptome of single cells based on RNA labeling. 2) Discover the mechanisms that induce cell state activation upon injury. We will combine single-cell transcriptomics and open chromatin profiling to infer gene regulatory networks, and we will use functional experiments to validate the identified pathways. 3) Reveal pro-regenerative cell types and understand their role in the regenerative process. We will combine spatial transcriptomics and computational analysis to identify putative cellular interactions, and we will use targeted cell type depletion and signaling inhibition to confirm our findings. In this manner, we will provide the first comprehensive view of how cell type activation leads to a synergistic response in organ regeneration. Furthermore, the approaches and concepts developed in this project will be applicable to other systems in regeneration and beyond. Finally, understanding the underlying mechanisms in zebrafish, the preeminent model for heart regeneration, will open up exciting avenues for awakening the dormant regenerative potential of the human heart.

Keywords: cell state transitions,single cell genomics,rna labeling,lineage tracing,spatial transcriptomics,heart regeneration,zebrafish
Next Generation Meta Operating System (NEMO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Greece,Finland,France,Romania,Luxembourg,Switzerland,Slovenia
Call: Future European platforms for the Edge: Meta Operating Systems (RIA) (HORIZON-CL4-2021-DATA-01, 2021)
Start date: 2022-09-01
End date: 2025-09-30
Duration (months): 37.0
Total project cost (EUR): 10499650.0
EU funding (EUR): 10499650.0
Participants: 30
Project status: SIGNED

NEMO aims to establish itself as the game changer of AIoT-Edge-Cloud Continuum by introducing an open source, flexible, adaptable, cybersecure and multi-technology meta-Operating System, sustainable during and after the end of the project, via the Eclipse foundation (NEMO consortium member). To achieve technology maturity and massive adoption, NEMO will not “reinvent the wheel”, but leverage and interface existing systems, technologies and Open Standards, and introduce novel concepts, tools, testing facilities/Living Labs and engagement campaigns to go beyond today’s state of the art, make breakthrough research and create sustainable innovation, already within the project lifetime. NEMO will introduce innovations at different layers of the protocol stack, enabling on-device Cybersecure Federated ML/DRL, deliver time-triggered (TSN) multipath ad-hoc/hybrid self-organized and zero-delay failback/self-healing multi-cloud clusters, multi-technology Secure Execution Environment and on-Service Level Objectives meta-Orchestrator, Plugin and Apps Lifecycle Management and Intent Based programming tools. Moreover, NEMO will be “by design” and “by innovation” cybersecure and trusted adopting state of the art mechanisms such as Mutual TLS and Digital Identity Attestation. NEMO will be validated in 5 most prominent industrial sectors (i.e. Farming, Energy, Mobility/City, Industry 4.0 and Media/XR) and 8 use cases in 5 +1 Living Labs, utilizing more than 30 heterogenous IoT devices and real 5G infrastructure. The impact will not only safeguard EU position in data economy and applications verticals, but lower energy efficiency, reduce pesticides and CO2 footprint. Beyond Eclipse adoption, NEMO sustainability, wide acceptance and SMEs engagement will be achieved via open source ecosystems, standardization initiatives and 2 Open Calls that will provide financial support of 1,8M€ and access to NEMO Living Labs to SMEs and enlarge NEMO by at least 16 new entities.

Keywords: edge computing,cloud edge continuum,meta orchestration,ai at edge
Remote control of multiple cell functions through multi-stimuli-responsive nanoparticle assemblies (CELL-NANO-REMOTE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-03-01
End date: 2031-02-28
Duration (months): 60.0
Total project cost (EUR): 1740080.0
EU funding (EUR): 1740080.0
Participants: 1
Project status: SIGNED

CELL-NANO-REMOTE aims to achieve flexible, remote control over therapeutic cell behaviour. In previous work in optogenetics and magnetogenetics, only partial remote cell control has been attained using light or magnetic fields as triggers. Furthermore, these approaches are generally limited to single cell responses, typically influencing one particular gene, receptor, or ion channel. In contrast, CELL-NANO-REMOTE seeks to obtain independent control over various cell functions without cross-activation upon application of external stimuli (light, magnetic fields or ultrasound). To surpass the limitations of current strategies and achieve the ambitious goal of the project, CELL-NANO-REMOTE combines various stimuli-responsive nanoparticles (NPs) and genetic engineering as ex vivo modification tools of the target cells. To ensure uniform and simultaneous uptake of all the different NPs by cells, they will be assembled into multi-NP assemblies. These multi-NP assemblies will be characterized by nano flow cytometry, a novel technique which enables optimization of assembly conditions to ensure the desired ratio of each component. In response to the application of external stimuli, the NPs will release different cargos inside the engineered cells, providing control over various cell functions. To demonstrate the potential of this approach to improve cell therapies, the project will unfold in two stages: a proof-of-concept stage using a model cell line followed by a second stage showcasing two case studies, in immunology and in regenerative medicine. The CELL-NANO-REMOTE approach will offer flexible, real-time command of cell behaviour, allowing for adaptable and dynamic control of cell responses. This remote-control system could revolutionize how we manipulate therapeutic cells, offering significant advancements for a wide range of pathologies. Furthermore, this strategy will have applications not only in cell therapy, but also in biotechnology more broadly.

Keywords: stimuli responsive nanoparticles