Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Clinical Studies on a Multivalent Vaccine for Human Visceral Leishmaniasis (MULEVACLIN)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Italy,Italy,Portugal,Spain,Switzerland,Czechia
Call:  (FP7-HEALTH-2013-INNOVATION-1, 2013)
Start date: 2013-11-01
End date: 2018-10-31
Duration (months): 60.0
Total project cost (EUR): 7449921.6
EU funding (EUR): 5475364.0
Participants: 9
Project status: CLOSED

The World Health Organisation in its report on Neglected Tropical Diseases has stated that there is overwhelming evidence to show that the burden caused by many of the 17 diseases that affect more than 1billion people worldwide can be effectively controlled and, in many cases, eliminated or even eradicated. Leishmaniasis caused by Leishmania spp is one of them and poses a grave health risk to an estimated 350 million people across the world. Among the three clinical patterns of Leishmaniasis (cutaneous, mucocutaneous, and visceral), Visceral Leishmaniasis (VL), also known as kala azar is the most severe in terms of symptoms and clinical complications. If left untreated, the disease can have a fatality rate as high as 100%.Only few drugs are available in the foreseeable future for treating patients from this disease. The development of a human vaccine against Leishmania is an achievable goal.In endemic areas, the majority of infected persons do not develop clinical symptoms and past infection leads to robust immunity against reinfection. In our approach, we mimic a natural infection cycle of Leishmania, by introducing the recombinant protein LJM11 from the sand fly saliva and two other components of Leishmania infantum based on well proven effective recombinant proteins from Leishmania: KMP11 and a recombinant fusion protein SMT-NH. These components will be formulated with a strong TLR4 agonist, already tested in humans, to enhance and modulate the immune response. This innovative vaccine will be tested at the Swiss Tropical and Public Health Institute, which already has experience in conducting clinical trials with Leishmania vaccines. The phase I/II clinical trial will be immunologically monitored by experienced institutions from EU and US. A European SME would have most of the benefits of this project: it would allow to further develop a vaccine against this neglected disease and increase the possibility to out-license this vaccine for commercialization.

Keywords: leishmania vaccine,visceral leishmaniasis,clinical trial
Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease: Comparative Effectiveness Research of Existing Technologies (DISCHARGE)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Germany,Austria,Belgium,Czechia,Denmark,Germany,Germany,Hungary,United Kingdom,Ireland,Italy,Italy,Latvia,Lithuania,Poland,Portugal,Spain,Switzerland,United Kingdom,United Kingdom,France,Netherlands,Spain,Germany,Romania,Serbia,Sweden
Call:  (FP7-HEALTH-2013-INNOVATION-1, 2013)
Start date: 2014-02-01
End date: 2020-01-31
Duration (months): 72.0
Total project cost (EUR): 7702421.0
EU funding (EUR): 5999995.0
Participants: 36
Project status: CLOSED

Coronary artery disease (CAD) is the leading cause of death in high-income countries. Invasive coronary angiography (ICA) is the reference standard for the diagnosis of CAD and allows immediate therapy. However, only 40% of patients undergoing ICA actually have obstructive CAD and ICA has relatively rare but considerable risks. Coronary computed tomography (CT) is the most accurate diagnostic test for CAD currently available. CT may become the most effective strategy to reduce the ca. 2 million annual negative ICAs in Europe by enabling early and safe discharge of the majority of patients with an intermediate risk of CAD. To evaluate this, we propose the DISCHARGE project that will be implemented by a multinational European consortium. The core of the project is the DISCHARGE pragmatic randomised controlled trial. The primary hypothesis will be that CT is superior to ICA for major adverse cardiovascular events (cardiovascular death, nonfatal myocardial infarction and stroke) after a maximum follow-up of 4 years in a selected broad population of stable chest pain patients with intermediate pretest likelihood of CAD. The trial will include 26 clinical sites from 16 European countries ensuring broad geographical representation. Comparative effectiveness research of complementing work packages include gender-related analysis, systematic review of evidence, cost-effectiveness analysis, and health-related quality of life. DISCHARGE has the capability to influence current standards and guidelines as well as coverage decisions and will raise awareness among patients, health care providers, and decision-makers in Europe about the effectiveness and cost-effectiveness of coronary CT angiography.

Keywords: coronary artery disease stable chest pain intermediate pretest likelihood pragmatic randomised controlled trial coronary computed tomography angiography invasive coronary angiography
Harmonized approach to stress tests for critical infrastructures against natural hazards (STREST)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Protecting citizens from environmental hazards
Action type: Collaborative project
Countries involved: Switzerland,Italy,Italy,Italy,Netherlands,France,Greece,Türkiye,Slovenia,European organisations area
Call:  (FP7-ENV-2013-two-stage, 2013)
Start date: 2013-10-01
End date: 2016-09-30
Duration (months): 36.0
Total project cost (EUR): 3975006.0
EU funding (EUR): 3000000.0
Participants: 13
Project status: CLOSED

Critical Infrastructures (CIs) provide essential goods and services for modern society; they are highly integrated and have growing mutual dependencies. Recent natural events have shown that cascading failures of CIs have the potential for multi-infrastructure collapse and widespread societal and economic consequences. Moving toward a safer and more resilient society requires improved and standardized tools for hazard and risk assessment of low probability-high consequence (LP-HC) events, and their systematic application to whole classes of CIs, targeting integrated risk mitigation strategies. Among the most important assessment tools are the stress tests, designed to test the vulnerability and resilience of individual CIs and infrastructure systems. Following the results of the stress tests recently performed by the EC for the European Nuclear Power Plants, it is urgent to carry out appropriate stress tests for all other classes of CIs. To this end, STREST will establish a common and consistent taxonomy of CIs; develop a rigorous, consistent modelling approach to hazard, vulnerability, risk and resilience assessment of LP-HC events; design a stress test framework and specific applications to address the vulnerability, resilience and interdependencies of CIs. STREST will focus on earthquakes, tsunamis, geotechnical effects and floods, and on three principal CI classes: (a) individual, single-site, high risk infrastructures, (b) distributed and/or geographically extended infrastructures with potentially high economic and environmental impact, and (c) distributed, multiple-site infrastructures with low individual impact but large collective impact or dependencies. STREST will work with key European CIs, to test and apply the developed stress test methodologies to specific CIs, chosen to typify general classes of CIs, with the final goal of enabling the implementation of European policies for the systematic implementation of stress tests.

Keywords: critical infrastructures,natural hazards,low probability high consequence events,disaster risk reduction,mitigation and adaptation,hazard and risk assessment,societal resilience,stress tests
A novel technology for detecting train wheels surface cracks by non destructive testing based on thermography (TRAINWHEELS)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: Spain,Germany,Italy,Israel,Spain
Call:  (FP7-SME-2013, 2013)
Start date: 2013-09-01
End date: 2015-08-31
Duration (months): 24.0
Total project cost (EUR): 1356731.0
EU funding (EUR): 1030852.5
Participants: 5
Project status: CLOSED

The European rail network is getting more and more important in the transportation sector: it hosts high speed-trains, higher loads of more passengers or goods, with increased frequency. This determines a higher mechanical load for the moving parts of the carrier involved: therefore, increasing inspection and maintenance are required in order to guarantee safety and well-being of trains. One of the biggest concerns about transportation safety is broken wheels due to internal cracks. Frequent accidents and regular breakdowns have been registered in the latest years due to this failure. Three testing methods have been investigated to identify cracks or problems on the surface or near the surface of the wheel: Magnetic Particle Inspection, Dye Penetrant Inspection, and eddy current testing. These methods show the following drawbacks: MPI and DPI generates high amount of hazardous waste and none of them is automatable, while the eddy current system is sensitive to lift-off variations and probes need to be positioned at a constant distance. In conclusion a new, more efficient, automated and faster method is needed to detect surface cracks. TRAINWHEELS face the challenge of optimizing thermography in order to use it as an automated train wheel crack detection method, meeting all European Safety Standards. Using thermography for train inspection would result in a big improvement compared to previously quoted methods: thermography is an automated and faster approach; it is as well cleaner and cheaper. At the moment, there is no better way of controlling the train wheel surface than with the use of thermography. Our aim is to improve train circulation safety by enhancing the effectiveness of non-destructive tests on wheels, in order to identify cracks as soon as possible. For this reason, we believe that a coupling between an existing method – the Ultrasound testing – and the proposed one, will suit the purpose of delivering a complete and self-consistent detection method

Keywords: artificial vision enhancement,temperature profile,thermography,surface crack detection,non-destructive techniques,induction generation
Solutions for present and future emerging pollutants in land and water resources management (SOLUTIONS)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Sustainable use and management of land and seas
Action type: Collaborative project
Countries involved: Germany,Netherlands,Slovakia,Sweden,European organisations area,Netherlands,Switzerland,Norway,Bulgaria,Germany,Netherlands,Spain,Germany,United Kingdom,Belgium,Germany,France,Serbia,France,United Kingdom,Austria,China,Czechia,Germany,Sweden,Australia,Brazil,Germany,Germany,United Kingdom,Netherlands,Germany
Call:  (FP7-ENV-2013-two-stage, 2013)
Start date: 2013-10-01
End date: 2018-09-30
Duration (months): 60.0
Total project cost (EUR): 16323009.85
EU funding (EUR): 11988935.2
Participants: 39
Project status: CLOSED

SOLUTIONS will deliver a conceptual framework for the evidence-based development of environmental and water policies. This will integrate innovative chemical and effect-based monitoring tools with a full set of exposure, effect and risk models and assessment options. Uniquely, SOLUTIONS taps (i) expertise of leading European scientists of major FP6/FP7 projects on chemicals in the water cycle, (ii) access to the infrastructure necessary to investigate the large basins of Danube and Rhine as well as relevant Mediterranean basins as case studies, and (iii) innovative approaches for stakeholder dialogue and support. In particular, International River Commissions, EC working groups and water works associations will be directly supported with consistent guidance for the early detection, identification, prioritization, and abatement of chemicals in the water cycle. A user-friendly tool providing access to a set of predictive models will support stakeholders to improve management decisions, benefiting from the wealth of data generated from monitoring and chemical registration. SOLUTIONS will give a specific focus on concepts and tools for the impact and risk assessment of complex mixtures of emerging pollutants, their metabolites and transformation products. Analytical and effect-based screening tools will be applied together with ecological assessment tools for the identification of toxicants and their impacts. Beyond state-of-the-art monitoring and management tools will be elaborated allowing risk identification for aquatic ecosystems and human health. The SOLUTIONS approach will provide transparent and evidence-based lists of River Basin Specific Pollutants for the case study basins and support the review of the list of WFD priority pollutants.

Keywords: analytical chemistry,bio-marker,mixture toxicology,environmental risk assessment,water policy
Resilience-Increasing Strategies for Coasts - toolKIT (RISC-KIT)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Protecting citizens from environmental hazards
Action type: Collaborative project
Countries involved: Netherlands,Germany,Italy,Portugal,Belgium,Bulgaria,France,Switzerland,Spain,Italy,Germany,Portugal,Sweden,United Kingdom,France,United Kingdom,France
Call:  (FP7-ENV-2013-two-stage, 2013)
Start date: 2013-11-01
End date: 2017-04-30
Duration (months): 42.0
Total project cost (EUR): 7654453.0
EU funding (EUR): 5999692.0
Participants: 19
Project status: CLOSED

Resilience-Increasing Strategies for Coasts – toolKIT (RISC-KIT) will deliver ready-to-use methods, tools and management approaches to reduce risk and increase resilience to low-frequency, high-impact hydro-meteorological events. The open-source and free-ware RISC-KIT tool kit will consist of ● a Coastal Risk Assessment Framework (CRAF) which - at the regional scale (100’s km) - can quickly assess present and future hot spot areas of coastal risk due to multi-hazards ● a quantitative, high-resolution Early Warning and Decision Support System (EWS/DSS) for use on these hot spots (with a scale of 10’s of km) and ● a web-based management guide offering innovative, cost-effective, ecosystem-based DRR measures; and ● a Coastal Risk Database of present and historic socio-economic and physical data. These tools will enable Europe’s coastal managers, decision-makers and stakeholders to ● identify hot spot areas; ● produce timely forecasts and early warnings; ● evaluate the effect of climate-related, socio-economic and cultural changes on coastal risk; and ● choose the best prevention, mitigation and preparedness measures for their coast. The toolkit will be tested using data collected on ten diverse case study sites along each of Europe’s regional seas and one international site. The toolkit’s performance will be evaluated with an End-User Board of coastal managers, civil protection agencies and local governments with a vested interest in each of these case study sites. The RISC-KIT products will help to achieve rapid attainment of UNISDR Disaster Reduction Goals and promote EU-consistent methods through innovative e-learning and open access publication. RISC-KIT will have an active synergy with Belmont Forum projects, related EU projects and an International Expert Board with members from third countries experiencing similar types of threats.

Keywords: early warning systems,bayesian decision support systems,coastal hazards,coastal flash floods,coastal morphology coastal risk database,end-user and stakeholder involvement,coastal risk assessment
Maximising the Exploitation of Linked Open Data In Enterprise and Science (MELODIES)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Mobilising environmental knowledge for policy, industry and society
Action type: Collaborative project
Countries involved: United Kingdom,Italy,Czechia,Portugal,Greece,United Kingdom,Spain,Germany,Germany,Netherlands,Germany,Spain
Call:  (FP7-ENV-2013-two-stage, 2013)
Start date: 2013-11-01
End date: 2016-10-31
Duration (months): 36.0
Total project cost (EUR): 6621444.6
EU funding (EUR): 5123473.45
Participants: 17
Project status: CLOSED

The European Open Data Strategy establishes important new principles that ensure that European public sector data will be released at no cost (or marginal cost), in machine-readable, commonly-understood formats, and with liberal licenses enabling wide reuse. These data encompass both scientific data about the environment (from Earth Observation and other fields) and other public sector information, including diverse topics such as demographics, health and crime. The intention of the Strategy is to stimulate the growth of research and value-adding services that build upon these data streams; however, researchers and industry are only just beginning to understand the benefits of exploiting Open Data and the value of combining previously-disparate sources of information. This project will develop eight new innovative and sustainable services, based upon Open Data, for users in research, government, industry and the general public. A broad range of societal benefit areas are covered, including agriculture, urban ecosystems, land use management, marine information, desertification, crisis management and hydrology. The long-term sustainability of the services will be assessed critically throughout the project from a number of angles in order to ensure that the full benefits of the project are realised in the long term. A comprehensive and coherent strategy of user engagement and dissemination will ensure that the project develops in response to real user needs. The project will provide the service developers with a collaborative technology platform that gives the computing capability required to handle and process such large and diverse datasets. It will allow them to focus on the design and evolution of their service, enable collaboration on common tasks and will contribute towards the long-term sustainability of the services. The platform will build extensively on previous European investments in cloud and grid computing and Linked Data technologies.

Keywords: open data linked data cloud computing geospatial data open standards services sustainability
Land use change: assessing the net climate forcing, and options for climate change mitigation and adaptation (LUC4C)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Coping with climate change
Action type: Collaborative project
Countries involved: Germany,United Kingdom,France,United Kingdom,Netherlands,Germany,Netherlands,European organisations area,Italy,Bulgaria,Russian Federation,United States,South Africa,China
Call:  (FP7-ENV-2013-two-stage, 2013)
Start date: 2013-11-01
End date: 2017-10-31
Duration (months): 48.0
Total project cost (EUR): 8005363.33
EU funding (EUR): 5999079.0
Participants: 15
Project status: CLOSED

LUC4C will advance our fundamental knowledge of the climate change - land use change interactions, and develop a framework for the synthesis of complex earth system science into guidelines that are of practical use for policy and societal stakeholders. Policies in support of climate change mitigation through land management, and the societal demand for other services from terrestrial ecosystems are currently rather disconnected, in spite of the large potential for co-benefits, but also the need for trade-offs. To identify the beneficial and detrimental aspects of alternative land use options, we will improve and evaluate a suite of modelling approaches at different levels of integration and complexity in order to (i) discern key elements of land-use that have the largest effect on climate, including dependencies across time and space, (ii) develop innovative methods to better quantify the dynamic interactions between land use and the climate system at different time and space scales, and (iii) deliver a portfolio of best practice guidelines for the identification of trade-offs, benefits or adverse effects of land-based mitigation policy options across different scenarios. In particular, LUC4C aims to: 1. enhance our ability to understand the societal and environmental drivers of land use and land cover change (LULCC) relevant to climate change; 2. assess regional and global effects of different mitigation policies and adaptation measures within alternative socio-economic contexts; 3. quantify how the LULCC-climate change interplay affects regional vs. global, and biophysical vs. biogeochemical ecosystem-atmosphere exchange, and how the relative magnitude of these interactions varies through time; 4. advance our ability to represent LULCC in climate models; 5. assess LULCC-climate effects on multiple land ecosystem services and analyse these in relation to other societal needs that provide either a synergy or trade-off to climate mitigation and adaptation.

Keywords: earth system model,climate change,land use change model,dynamic global vegetation model,ecosystem services,land-based mitigation policy,integrated assessment model,climate change adaptation
High Shear Processing of Recycled Aluminium Scrap for Manufacturing High Performance Aluminium Alloys (RECYCAL)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Improving resource efficiency
Action type: Collaborative project
Countries involved: United Kingdom,Ireland,Italy,Italy,United Kingdom,Spain,Spain,Portugal,Spain,Germany
Call:  (FP7-ENV-2013-two-stage, 2013)
Start date: 2014-01-01
End date: 2016-12-31
Duration (months): 36.0
Total project cost (EUR): 3130117.35
EU funding (EUR): 2396209.0
Participants: 13
Project status: CLOSED

The EU wrought aluminium industry is based on the use of primary aluminium. Primary aluminium production is both energy and carbon intensive and EU production is rapidly declining. Secondary aluminium (post-consumer scrap) is either downgraded into low quality cast products, or exported. This scrap could be transformed into a low cost, low carbon feedstock for wrought product and high quality castings by the adoption of High Shear Processing (HSP) technology. This innovative new technology is based on a novel physical melt conditioning process that can be applied both to batch and continuous metal processing. It is based on leading edge research into the heterogeneous nucleation and growth in aluminium alloys, and its promotion by dispersed oxides. This research at Brunel University has demonstrated that the physical processing of liquid metals transforms oxides in melts from defects to active nuclei. This results in refined cast microstructures with significantly improved mechanical properties. The physically conditioned liquid can be used in all casting processes, including shape casting and the casting of rolling blocks or extrusion billets. The project will bridge the gap to industrialization through the involvement of a research-capable SME who will design and manufacture a prototype small industrial-scale HSP unit and then make recommendations regarding improved equipment design and likely process costs. Other SME partners will assist with economic modelling, through a life cycle analysis, which will comprise the costs of the process and the energy savings together with the impact in the carbon footprint. RecyCAL could have a major impact on the EU wrought and cast aluminium industry, leading to the consolidation of the primary and secondary industry sectors. The project could transform the EU aluminium metals cycle from one that is currently resource intensive to one that is sustainable.

Keywords: recycling,aluminium,mbt,low carbon,energy saving,sme,industrialization,casting,high shear,rheocasting,modelling,life cycle,solidification,microstructure.