Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
STRATIFIED HOST-DIRECTED THERAPY FOR DRUG-RESISTANT TUBERCULOSIS: A RANDOMIZED CONTROLLED MULTI-CENTRE TRIAL (DRTB-HDT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,South Africa,Germany,Belgium,Moldova, Republic of,Romania,Switzerland,Georgia,Mozambique
Call: Stratified host-directed approaches to improve prevention, treatment and/or cure of infectious diseases (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 9969012.25
EU funding (EUR): 9969012.25
Participants: 10
Project status: SIGNED

Tuberculosis is a leading cause of morbidity and mortality worldwide. Current TB treatments are inadequate, requiring patients closely adhere to multi-drug regimens that are long, complex, and often poorly tolerated. These concerns are greatly magnified in rifampicin-resistant (RIF-R) TB, an urgent global and EU public health priority. WHO estimates that only 54% of patients who began RIF-R TB treatment in 2016 were cured. In addition to these well-recognized shortcomings, current TB treatments, particularly those for RIF-R TB, leave a majority of cured patients with permanent, clinically significant lung impairment and radiographic evidence of bronchiectasis and fibrosis. This project will determine if two adjunctive host-directed therapies (HDTs) can prevent these poor outcomes. 330 patients with RIF-R TB and baseline risk factors for poor outcome will be enrolled in a randomized, controlled, 3-armed multi-centre trial, with clinical sites in Germany, Romania, Moldova, Georgia, Mozambique, and South Africa. All patients will receive standard multidrug therapy according to national guidelines. Those patients randomized to the experimental arms will in addition receive either CC-11050 or metformin. These selected HDT candidates represent 2 complementary HDT strategies: reducing inflammation vs inducing host cell anti-microbial activity, respectively. Both candidates are supported by data from preclinical and clinical studies. Co-primary efficacy endpoints will examine effects on lung function (measured by spirometry) and infection (measured as time to stable sputum culture conversion). A sub-study will examine quantitative change in lung radiodensity by CT scan. If successful, this ground-breaking project will increase Europe’s capacity to control RIF-R-TB by developing new treatments that increase the likelihood of cure and reduce the risk of life-long disability.

Keywords: tuberculosis
The role of PV+ basket cell axon myelination in temporal synchrony of the hippocampal CA2 network (MyeSync)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-03-15
End date: 2023-03-14
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

The hippocampus located in the temporal lobe of the brain is of fundamental importance for storage and retrieval of episodic memories. Such brain computations take place at a time scale of milliseconds or less, and rely on neuronal information transfer over subcellular structures which are called axons. Neuronal precision and speed can be achieved by wrapping axons with multi-lamellar membrane sheets of myelin and is of critical importance for proper brain function. Until recently, myelination was thought to be exclusive to long-range excitatory neuronal projections. This view has been drastically revised, and it is now commonly accepted that myelination can be abundant around the axons of local inhibitory interneurons as well. Parvalbumin positive basket cells (PV+ BCs) are fast spiking interneurons which are prominent in the hippocampus where they contribute to the synchrony of action potentials of large populations of neurons. They function as clockworks that drive network oscillations such as sharp wave ripples, are critical for memory consolidation, and are highly abundant in hippocampal area CA2. Whether myelination of the CA2 PV+ BC axon plays a role in their temporally precise inhibitory function, and whether this supports temporally precise neuronal encoding and cognitive performance remains obscure. In this Marie Skłodowska-Curie fellowship, I will address this question by combining my expertise in subcellular patch-clamp methods with the expertise of the host on Ca2+ imaging, myelin physiology, and in vivo electrophysiology. The proposed multimethod and multidisciplinary study will be unique in showing how biophysical changes in small neuronal compartments will lead to alterations of neuronal networks and ultimately to behavioral alterations of the organism. The fellowship is expected to provide me with transferable skills and high throughput techniques that will greatly improve my chances to become an influential leader in the field of neuroscience.

Keywords: hippocampus,patch clamp,interneuron,parvalbumin,axon,myelin,release terminal
Metal-Functionalized Cavitands for a Site-Selective C-H hydroxylation of Aliphatic Compounds (Met_Cav)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Israel
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-11-01
End date: 2025-04-30
Duration (months): 66.0
Total project cost (EUR): 1438750.0
EU funding (EUR): 1438750.0
Participants: 1
Project status: SIGNED

Selective hydroxylation of abundant, but chemically inert C-H bonds remains one of the great challenges in modern chemistry. Given that the resulting alcohols can easily be converted into a variety of other functional groups, this process is key to the large-scale production of commodity chemicals from a natural feedstock. Consequently, developing sustainable and environmentally benign catalysts capable of performing this transformation by utilizing cheap oxidants is of utmost importance. Such catalysts must be reactive enough to overcome the chemical inertness of C-H bonds, yet avoid over-oxidation, and be able to distinguish the target reaction site from other C-H bonds present. Although in recent decades significant progress has been achieved in catalytic hydroxylation of methane and ethane, selective hydroxylation of heavier alkanes (as well as of alkyl chain residues particularly at the terminal position) is still only possible by natural metalloenzymes. While being environment-friendly and functioning under mild conditions, these natural catalysts are poorly applicable to large-scale industrial processes due to their low stability and high cost. Nevertheless, the underlying principles such as (1) reactive metal centers embedded in hydrophobic pockets, (2) structurally defined reaction environment, and (3) affinity-based differentiation between substrates and products, can be capitalized upon for constructing a new generation of synthetic catalysts. The project will demonstrate how these rationales can be implemented with novel metal-functionalized cavitands – inner cavity containing molecules with a rigid metal-binding site accessible only from their interior. This fresh design combines the oxidative power of high valent metal-oxo species with the chemoselectivity for hydrophobic substrates, necessary to avoid product over-oxidation, while the desired site-selectivity is achieved by a well-defined spatial orientation of the encapsulated substrate molecules.

Keywords: c h activation,first row transition metals
Quantum Semiconductor Technologies Exploiting Antimony (QUANTIMONY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Spain,Italy,Germany,Germany,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2020-12-01
End date: 2024-11-30
Duration (months): 48.0
Total project cost (EUR): 3769297.92
EU funding (EUR): 3769297.92
Participants: 11
Project status: SIGNED

Due to their unique properties, research into the quantum physics and engineering of Sb-based compound semiconductor (III-Sb) materials and devices is flourishing worldwide. However, III-Sb penetration into the electronic and optoelectronic markets falls substantially short of their potential. The objective of QUANTIMONY (Innovative Training Network in Quantum Semiconductor Technologies exploiting Antimony) is to provide high-level training to fourteen early stage researchers (ESRs) in the overarching field of III-Sb semiconductor science and technology, covering all scientific and engineering aspects from modelling through to material growth and characterisation, device fabrication and analysis, and industrial exploitation. Via QUANTIMONY the beneficiaries and partners will prepare this cohort of researchers for, and jointly instigate, the transition of III-Sb materials from their current status of high-performance, high-cost niche application towards scalable and industrially relevant technologies. To fulfil this mission, we propose a 48-month project with seven work packages, four of which focus on III-Sb research activities that will accelerate the development of new technologies. QUANTIMONY is configured as a multi-site network comprising eleven internationally-renowned research teams as beneficiaries: seven universities, one research institute, two large corporations and one SME. It is enhanced by twelve partner organizations, six of which are industrial partners, three are large scale research facilities and three are internationally-leading academic groups. The combined consortium spans eleven countries: eight European, plus USA, Taiwan and Brazil.

Keywords: quantum semiconductors,insb,gasb,alsb,mocvd,memories,single photon sources,solar cells,infrared technology,quantum simulations,atomistic theories,micro and nanocharacterization
Iminoboronate polymers as dynamic smart materials (IminoBoron)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Dynamic polymers, which are able to break and reform due to the dynamic nature of their linkages, can be considered as a new class of smart materials, since they can be altered and/or respond to different external stimuli. We propose a new class of dynamic, conjugated polymers based on the reversible iminoboronate ester bonding motif. Simple monomers containing aldehyde, amine, and boronic acid functionalities will polymerize together with diols to produce iminoboronate ester polymers. The presence of orthogonal dynamic imine and boronate ester bonds will allow us to develop easily functionalizable, and thus tuneable, multicomponent polymer materials that possess the ability to reorganise or adapt in response to various external stimuli. The incorporation of electronically distinct diols, will permit us to tune the photophysical and chemical properties of the conjugated polyimine polymer backbone, enabling the possibility to attain the desired material properties. These multifunctional materials will be investigated as fluorescent polyreceptors for specific diols and as controllably crosslinkable or decrosslinkable materials with the addition or displacement of tetrols. Moreover, development of these high-value smart materials will lay the groundwork for the next generation of multifunctional devices, such as blue-light-emitting polymers with superior efficiency and electrochemical stability to the state-of-the-art poly(fluorene) and GaN (O)LEDs.
PROGRESSIVE STANDARDS AROUND ICT FOR ACTIVE AND HEALTHY AGEING (PROGRESSIVE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Coordination and support actions
Countries involved: Germany,Spain,Italy,Italy,Belgium,Belgium,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Standardisation needs in the field of ICT for Active and Healthy Ageing (H2020-SC1-2016-CNECT, 2016)
Start date: 2016-10-01
End date: 2019-01-31
Duration (months): 28.0
Total project cost (EUR): 905781.25
EU funding (EUR): 905781.25
Participants: 11
Project status: CLOSED

The PROGRESSIVE project will provide a dynamic and sustainable framework for standards and standardisation around ICT for AHA. The project is pan-European but also draw on wider international experience – especially in the contexts of interoperability and standards harmonisation. As attitudes towards ageing change there is recognition of the importance of older people’s engagement. Engagement can empower. It can encourage and facilitate greater involvement of older people in economic and political life as well as within communities and families. It follows that the inclusion of older people must be integral to ways of thinking about standards for ICT for AHA. Traditional top-down, clinically driven approaches to standards often fail to recognise the importance of such engagement and overlook the opportunity of co-production approaches. A strongly ethical approach is adopted in the PROGRESSIVE project. It uses responsible research and innovation (RRI) as a key reference point. The new way of thinking adopted involves a dialogue that moves from what can be a formulaic standards and service ‘delivery’ model in favour of provision in ways that take fuller account of needs and choices of older people. The PROGRESSIVE project recognises four domains - age friendly communities; reformed and empowering services; accessible, affordable and supportive homes; and active, health and empowered older people and 22 fields (Fig 1). Within these it acknowledges the commercial opportunities of the ‘silver economy’ - both as a market for goods and services and as a milieu where older people can be assets and active contributors. The PROGRESSIVE project will establish parameters by which good practice in standards and the standardisation process around ICT for AHA can be identified. A platform to be developed will promote discussion and debate. The work will lay the foundation for standards that will be increasingly fit for purpose – with potential benefits to all our lives.

Keywords: inclusion,standards,standardisation,co production,empowerment
Hybrid Indium Phosphide on Silicon nanophotonics for ultimate laser diodes, flip-flops and memories (HYPNOTIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-04-01
End date: 2023-09-30
Duration (months): 78.0
Total project cost (EUR): 1981721.0
EU funding (EUR): 1981721.0
Participants: 2
Project status: SIGNED

The HYPNOTIC project aims at achieving a breakthrough in Silicon laser science and technology by taking forward the III-V semiconductors on Silicon hybrid technology into the nanophotonic world to make the dream of the convergence of microelectronics and photonics on a chip come true. This project intends to take up the challenge of bringing to reality electrically powered photonic crystal nanolasers as reference sources for dense integration and logical processing in a Silicon-based optical platform by accomplishing: (i) power efficiency with extremely low activation energies of few fJ, (ii) high bandwidth beyond 40Gbits/s, (iii) compactness with footprints less than 100µm² for high integration density of 103-104 of devices per mm2. A paradigm change will be brought to Silicon photonics by laying down 3 corner stones which consist firstly in the realisation of ultimate nanolaser diode sources at telecom wavelengths using an optimised single hybrid active nanocavity. Secondly, the groundbreaking atomic physics concepts of superradiance and lasing without inversion of population resonators will be transposed to nanophotonics by coupling several active nanocavities. Besides studying them for their fundamental interest, the project will capitalise on them to drastically augment the power efficiency and the modulation bandwidth of the nanosources. Finally, the fabricated nanolaser diodes using these novel concepts will be exploited to demonstrate cutting-edge flip-flop and memory devices able to surpass current off-chip electronic random access memories in access times and bandwidth which could enable unprecedented computational power.
Discover Research Dublin - European Researchers' Night 2014/2015 (DiscoverResearch)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Ireland
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-06-01
End date: 2015-11-30
Duration (months): 18.0
Total project cost (EUR): 175162.5
EU funding (EUR): 175162.5
Participants: 1
Project status: CLOSED

Ireland’s leading university, Trinity College Dublin (TCD), in partnership with the Royal College of Surgeons in Ireland (RCSI), is seeking funding to plan, promote and host Discover Research Night as part of European Researchers’ Night in 2014 and 2015. On Discover Research Night 26 September 2014 and 25 September 2015, TCD and RCSI will offer the general public a wide range of interactive and hands-on activities, providing direct contact with researchers and allowing for discovery, questions and participation. The objectives of the project are to challenge perceptions held by the general public about researchers, to promote research as an exciting career option, to demonstrate creativity and innovation in research across all disciplines and to show that researchers are dynamic contributors to society. Interaction with researchers during EU Researchers’ Night will challenge stereotypes which have created barriers between the general public and researchers. Specific career-focused events will identify and promote arrays of opportunities for research careers. Diverse activities which will help to show the public how research benefits the community. Events will showcase exciting innovative research from several academic strands at TCD and RCSI, will invite the public to interact with the vibrant research communities from both participating institutes, aiming to delight and stimulate the imagination of all participants from school children and their families, to visitors to Dublin and the local community. Activities hosted on the night will be grouped under four broad themes – Body Parts including ‘Discover the Brain!’, ‘Mending Broken Hearts, ‘Attack of the Heart’; Language, Thought & Knowledge Transfer including ‘Identities in Transformation’, ‘Living Thought/Thinking Life’, ‘Tower of Babel’, Creativity in Research featuring ‘Biodiversity in our Lives’ and Meet the Researchers including ‘Thesis-in-3’, ‘Innovation Café’, ‘Women in Science’ and ‘Career Clinic’.

Keywords: communication,science communication,public recognition of researchers,promotion of science careers
Disruptive process for the construction of railway transition zones, reducing drastically construction and maintenance costs (DIGITALIA 2)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 2182598.0
EU funding (EUR): 1527818.6
Participants: 1
Project status: CLOSED

When a train crosses from an embankment area to a bridge, tunnel or viaduct (transition zone), there is an abrupt change invertical stiffness, accelerating track degradations and generating vibrations. Hence, the embankment at transition zones are constructed differently to the rest of the track, using cement-treated soil to constitute a wedge shaped backfill. However, this construction is complex, uncertain and time-consuming, while not completely solving the vertical stiffness transition. Consequently, maintenance needs of transition zones are up to 6 times higher than regular tracks,requiring yearly about 471M€ (10% EU investment in track maintenance), while only accounting for 2,8% of total length. TORRESCAMARA has developed DIGITALIA 2,an innovative solution for transition zones based on precast concrete slabsthat properly smooth vertical stiffness and maintain this performance over time, with the aim of: 1) Simplifying and speeding up the construction process, 2) Reducing costs of the construction process, 3)Reducing maintenance operation needs, and 4) Reducing the associated vibrations to improve passenger comfort. The successful execution of Phase1 has led to the definition of a business model to deploy DIGITALIA 2 and reach EU market, establishing strategic alliances with potential stakeholders, users as well as commercial suppliers.In Phase2, our overall objective is to introduce DIGITALIA 2 in the market through the construction of an advanced demonstration element in the most complex and demanding conditions. We will also develop tools to ease and speed up the design,manufacturing and construction process. We will ensure a quick market deployment and promote the inclusion of DIGITALIA 2 in the specifications of railway infrastructure owners. As a result, the commercialization of DIGITALIA 2 will lead to a revenue of nearly152M€ and a benefit of 13M€ by the 5th year, while saving construction managers over 98M€ in construction cost and 8M€ on maintenance.

Keywords: railway,disruptive construction process,railway transition zones,maintenance and construction costs