Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Citizen Led Air pollution Reduction in Cities (CLAiR-CITY)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Hungary,Poland,Slovenia,Norway,Belgium,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,Portugal,United Kingdom
Call: Improving the air quality and reducing the carbon footprint of European cities (H2020-SC5-2015-two-stage, 2015)
Start date: 2016-05-01
End date: 2020-07-31
Duration (months): 51.0
Total project cost (EUR): 6692547.5
EU funding (EUR): 6692547.5
Participants: 17
Project status: CLOSED

CLAiR-City will apportion air pollution emissions and concentrations, carbon footprints and health outcomes by city citizens’ behaviour and day-to-day activities in order to make these challenges relevant to how people chose to live, behave and interact within their city environment. Through an innovative engagement and quantification toolkit, we will stimulate the public engagement necessary to allow citizens to define a range of future city scenarios for reducing their emissions to be used for supporting and informing the development of bespoke city policy packages out to 2050. Using six pilot cities/regions (Amsterdam, NL; Bristol, UK; Aveiro, PT; Liguria, IT; Ljubljana, SI; and Sosnowiec, PO), CLAiR-City will source apportion current emissions/concentrations and carbon emissions not only by technology but by citizens’ activities, behavior and practices. CLAiR-City will explore and evaluate current local, national and international policy and governance structures to better understand the immediate policy horizon and how that may impact on citizens and their city’s future. Then, working with the new methods of source apportionment to combine both baseline citizen and policy evidence, CLAiR-City will use innovative engagement methods such as Games, an App and Citizen Days to inform and empower citizens to understand the current challenges and then subsequently define their own visions of their city’s future based on how their want to live out to 2050. The impact of these citizen-led future city scenarios will analysed, to develop city specific policy packages in which the clean-air, low-carbon, healthy future, as democratically defined by the city citizens, is described and quantified. The results of the CLAiR-City process will be evaluated to provide policy lessons at city, national and EU levels. Additionally, the toolkit structure will be developed for all EU cities with more than 50,000 citizens establishing a basis to roll out the CLAiR-City process across Europe.

Keywords: climate change,citizen engagement,air pollution reduction in urban areas
regulation of B-cell Epitope migration and Autoimmunity by T follicular helper cells (BEAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2023-07-01
Duration (months): 36.0
Total project cost (EUR): 260929.8
EU funding (EUR): 260929.8
Participants: 2
Project status: SIGNED

The detection of autoantibodies typically appear a few years prior to clinical autoimmune disease and their reactivity can drift at or after disease onset. The laboratory of M.C. Carroll (outgoing institute) has developed a murine model (ARTEMIS; Autoreactive B-cell driven T-dependent Epitope Migration towards Immunity to Self) where the presence of a single autoreactive B cell clone drives activation, expansion and differentiation of other autoreactive B-cells in spontaneous germinal centers (GC) followed by autoantibody deposition in the kidney. These autoreactive B-cells target multiple other self-antigens (also known as epitope spreading) and are independent of the initial trigger once tolerance is broken. Follicular T helper (Tfh) cells play a prominent role in the selection of B-cells in the GC and have been linked to excessive GC formation, high-level production of pathogenic autoantibodies and end-organ damage in murine and human autoimmune disease. With this project I will address the role of Tfh cells in the maturation process of the self-reactive B-cell response and epitope spreading as observed in human autoimmune disease. Preliminary results show dependence of T cells, the extent and nature of T-cell involvement is however not yet addressed. I will utilize the mixed bone-marrow chimera model (ARTEMIS) in combination with selected strains altered in important factors for Tfh function and differentiation. As the GC reaction is a highly dynamic process we will visualize this utilizing multi-photon intravital microscopy and analyze important interactions of Tfh cells in the developing autoreactive GC. The development of autoreactivity from WT B-cells in the ARTEMIS model better reflects natural autoreactive GC behavior and human autoimmune disease and could therefore favor the transition of potential therapeutic targets from murine to human disease.

Keywords: multi photon intravital microscopy,germinal center dynamics,follicular helper t cells
BrainPatch – Breakthrough non-invasive brain stimulation using AI (BrainPatch)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The World Health Organization reports that various types of neurological disorders affect millions of people around the world, including for example 24 million that suffer from Alzheimer’s disease. Having a relative or a loved one affected by disorders of the central nervous system is devastating as it can change their personality, emotions and actions, but for many of those diseases there are still no adequate treatments. Not to mention the burden on the health system. While most companies would focus on addressing a specific problem or a specific disease, BrainPatch approach aims to eventually address all the problems associated with boosting the brain functions, with alleviating the disorders and any diseases that are indirectly affected by it. Our core technology improves the effectiveness of the non-invasive brain stimulation and uses reinforcement machine learning algorithms for real-time optimisation. The technology entails simultaneous recording and stimulation of the brain signals using electrodes contacting the scalp. And the innovation is in adaptation of the stimulation protocol in real-time by using a machine learning algorithm in a closed loop. BrainPatch is a B2B platform for developing apps for non-invasive brain stimulation using AI. The business model relies on a community of AI developers developing and testing machine learning algorithms for real-time optimisation of stimulation protocol for each application for each individual. The technology will use blockchain-enabled infrastructure for ensuring secure records of efficacy, and for maximising safety and trust in the applications. The economics of BrainPatch’s business are highly compelling. Since the potential end-users of BrainPatch are people who need to improve the brain performance or people who need to treat their mental disability, the Total Addressable Market is more than 212 bln EUR in EU28.

Keywords: neurological disorders,brain functions,elderly,cognitive disabilities,non invasive brain stimulation,machine learning algorithms,real time optimisation,blockchain,wellbeing,platform
Novel services for future proof agencies and SMEs (FUTURE PROOF)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Austria,Germany,Greece
Call: Peer learning of innovation agencies (H2020-INNOSUP-2018-2019-05, 2019)
Start date: 2020-04-01
End date: 2021-06-30
Duration (months): 15.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

Future Proof is a novel knowledge exchange and co-design platform that uses foresight and scenario planning methodologies to co-develop novel innovation services for SMEs. It will take into account the rapid and complex changes of the world in order to use suitable methods and technologies that will respond to the future needs of our SME clients. The three innovation agencies of the Future Proof consortium, have worked for almost three decades with clients providing innovation support services. Numerous clients and participants in seminars and workshops have raised the question that caught our attention: ‘How do you compete successfully in this endlessly changing world? During the last decades colossal changes have radically changed the innovation environment and the business arena. Digitalization, sharing economy, automation, the rise of China, climate change are only few of the drivers that have created new risks, opportunities and challenges for both the SMEs and the innovation agencies. Nevertheless, SMEs and innovation agencies have done little to change their traditional modus operandi, thus facing serious difficulties to address current and future challenges. Innovation agencies for the last 3 decades are basically offering the same bouquet of services while the same applies for the available innovation SME support programs. Considering the above overall objective of the Future-Proof project is threefold: (i) To utilise strategic foresight methodologies for designing new services and/or programs that will respond to the future needs of our SME clients. (ii) To exchange best-practices in designing and implementing foresight related services to SMEs that will create high-performance resilient future-proof SMEs. (iii) To broadly communicate the project outputs to the European innovation ecosystem.

Keywords: foresight,future,innovation,strategy
Genomic diagnostics beyond the sequence (BeyondSeq)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Israel,Belgium,Sweden,Sweden,France,United Kingdom,United Kingdom
Call: Development of new diagnostic tools and technologies: in vitro devices, assays and platforms (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-05-01
End date: 2019-04-30
Duration (months): 48.0
Total project cost (EUR): 6034026.09
EU funding (EUR): 6034026.09
Participants: 8
Project status: CLOSED

Cytogenetic diagnostic approaches provide information on the single-chromosome level but suffer from low resolution and throughput. In contrast, next generation sequencing (NGS) based diagnostics provides single base resolution and high throughput but suffer from short reads that prevent analysis of large genomic aberrations as well as being prone to PCR-amplification bias and erasure of epigenetic information. This proposal aims to bridge the gap between these domains by analyzing long individual DNA molecules without PCR-amplification via utilization of emerging optical DNA mapping technologies. We specifically address three types of challenges to current genomic based diagnostics: 1. Loss of relevant information such as DNA damage lesions, rare mutations or epigenetic markers following PCR amplification. 2. Limitations in resolving long-range variations in genomic layout and correlating them with single point mutations, preventing large scale screens. 3. Limitations imposed by the sample such as low sample amounts (micro biopsy, circulating tumor DNA) or inhomogeneous/highly variable samples (bacterial cultures). We will develop a robust toolbox for integrated genetic and epigenetic profiling of single DNA molecules that will include automated sample preparation of native unamplified DNA as well as the hardware and software platforms and analysis tools for readout, extraction and quantification of medically relevant genomic information. This technology will be used to develop a set of specific, proof of principle diagnostic assays based on optical barcoding of individual DNA molecules. These assays will address: -Bacterial infections and antibiotic resistance -Diagnosis/prognosis tools for hematological malignancies -Spinal Muscular Atrophy -Early diagnosis of colorectal and lung cancer. Ultimately our project will provide reagents, prototype DNA barcoding devices and data analysis software ready for large scale validation and early stage commercialization.

Keywords: single molecule,optical mapping,dna barcoding,nanopore
Smart Loading Zones in EU and Global market to regulate, control and monitor City Logistics - Last Mile Delivery in dense urban areas, based on Bluetooth devices and mobile apps for commercial drivers (PARKUNLOAD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Nowadays, many mid-size and large-size cities face really severe problems accommodating growing urban freight transit and its related parking demand due to e-commerce effcet while striving to improve citizens’ quality of life by reducing greenhouse gases, air pollutants emissions and environmental noise. Most of these urban freight challenges can be confronted by implementing a COMPLETE DIGITALIZATION of the loading zones in the denser areas of the city, which creates a win-win situation where citizens, authorities and commercial drivers benefits to improve city logistics. Parkunload is a globally innovative IoT (Internet of Things) platform to efficiently regulate and control LOADING ZONES in urban areas, by installing smart road signs (with Bluetooth Low Energy (BLE) devices) and by using a mandatory mobile app for commercial drivers. With Parkunload’s system the city can flexibly and digitally manage vehicles’ LOADING PERMIT and MAXIMUM LOADING TIME depending on several criteria, such as: vehicle emissions, type and tonnage, as well as driver’s profile (commercial, private, resident, …), accurate location, time of the day and during POLLUTION EPISODES. As a scalable and real-time platform, Parkunload turns to an excellent source of BIG DATA to monitor and a analyse city logistics. The business model of Parkunload relies on several REVENUE CHANNELS from cities, commercial drivers, private estates (university campuses, hospitals), research institutes, parking app companies and automotive companies. The smart loading zones’ global market and its related revenue channels weighs up to 20B€ worldwide. Since June 2018, Parkunload’s platform has been deployed with a mandatory basis in some cities in Spain and is currently being deployed as a pilot in other European cities such as Dublin (IE), Belfast (UK) and Stuttgart (DE). Parkunload has been also awarded by the main URBAN FREIGHT LAB in Seattle (US).

Keywords: smart loading zones,urban freight,city logistics,apps,big data,advanced urban mobility,policies,last mile delivery solutions
COating for SMArt GREENhouses (COSMAGREEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Plants do not harvest the whole solar spectrum equally at the different wavelengths. They indeed reflect green, absorbs red and blue, so that we see them green. The consequence of that is that the solar spectrum is actually not optimised for energy conversion. However, incoming solar spectrum can be modified in order to shift less efficient wavelengths to more efficient one (like green to red) using fluorescent pigments or phosphors. In this way, photosynthesis efficiency can be increased. Meanwhile, when one uses standard fluorescent pigments implemented in a coating at the top of a greenhouse, half of the converted sunlight is emitted back to space due to their isotropic emission, thus lowering the conversion efficiency. To overcome this limit, we propose to use the properties of nano antennas for which it has been shown that they can change the emitting direction of pigments when they are placed in their vicinity. We will design a greenhouse coating that enhance photosynthesis by increasing the effective light inside greenhouses using coatings having nano-antenna phosphor pairs. Firstly, we will perform numerical calculations considering near field radiation and fluorescence, in order to find an optimum design in terms of antenna and phosphor size. Then, the coating will be produced in collaboration with a deposition facility using corresponding parameters from the numerical study. Finally, the actual design will be characterised using spectroscopy to determine the discrepancy between numerical and experimental study. Further actions like changing numerical solver and/or fabrication methods will be considered after a feedback from the two studies.

Keywords: photosynthesis,fluorescence,near field radiation,greenhouse,coating
NanoPowder Plant – Metal nanopowders for a world of great opportunities (NPP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Lithuania
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2020-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Current supply of metal nanopowders on the world market falls short on demand up to 15% , creating further obstacles to the technical progress in such industries as aerospace manufacturing, power machinery, engineered materials production, metal welding, heavy machinery, civil engineering and others. Metal nanopowders’ market is still only emerging due to low production capacities and insufficient purity, shape consistency and wide dispersion of nanoparticles produced, resulting in insufficient quality of such materials for key users. Nanopowder Plant (NPP), a Lithuanian based start-up, presents a revolutionary solution which has 8 times prevalence over other technologies in production capacity of metal nanopowders with the highest existing quality of the nanopowder produced. Moreover, it ensures low environmental pollution due to 80% energy efficiency of the solution and absence of need to use waste-generating chemical reagents during production process. Innovative production process, patented technology and experience team will help NPP to utilize market opportunity and obtain a strong position in the growing metal nanopowders market, which is projected to reach 60 bn USD in 2019 and accelerate further at 15-17% annual grows rate. NPP aims at global commercialization of its innovative solution to enable vast industrial application of metal nanopowder bringing superior value to end-customer and ensuring environmental protection. During the Phase 1 of SME Instrument feasibility study NPP wants to validate its market strategy through conducting thorough study of an emerging market and potential customers, strengthen IPR portfolio, modify existing commercialization strategy and develop an elaborate business plan.

Keywords: metal nanopowders,high energy electron beam,vacuum evaporation,metal nanoparticles,particles acceleration,oxide nanoparticles,additive technology,material production,nanoadditives
Development of New therapies against cholangiopathies. (New Chol)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany,United Kingdom
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-12-01
End date: 2023-11-30
Duration (months): 72.0
Total project cost (EUR): 2499111.0
EU funding (EUR): 856749.46
Participants: 2
Project status: SIGNED

Cholangiopathies represent a diverse group of diseases affecting cholangiocytes which are the main cell type of the biliary tract. These disorders range from inherited (Cystic Fibrosis) and developmental (Alagille Syndrome, Biliary Atresia) to autoimmune (Primary Biliary Cirrhosis), idiopathic (Primary Sclerosing Cholangitis) and drug or toxin induced diseases. Cholangiopathies result in toxic bile accumulation in the liver inducing cell death and ultimately cirrhosis. They carry high morbidity and mortality, accounting for up to a third of chronic liver disorders. Whole liver transplantation remains the main treatment. However, organ transplant requires immunosuppression with significant side effects and an increasing number of patients die while on the transplant list due to the shortage of suitable donors. Finally, the absence of physiologically relevant in vitro systems to model and to study cholangiopathies prevents the development of new therapeutics while cell based therapy approach have been unexplored. Here, we propose to systematically address these challenges by developing a novel and innovative program of translational research focusing on cholangiopathies. We will first investigate the cellular and functional diversity of the biliary tract and its impact on disease by taking advantage of recent developments in single cell transcriptomic analyses. We will then use this basic knowledge to generate and to characterize for the first time a renewable source of cholangiocytes from human induced pluripotent stem cells and from biliary tissue. The resulting cells will be used to model cholangiopathies in vitro and to create a new platform for drug target identification. Finally, we will explore the potential for in vitro generated cholangiocytes to be used in regenerative medicine applications including cell based therapy. Overall this comprehensive program will uniquely path the way for the development of a whole range of new therapies for cholangiopathies.

Keywords: human pluripotent stem cells,organoid,liver disease,cholangiocytes,cholangiopathies,biliary tract