Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Non-Noble Metal Catalysis - NoNoMeCat (NoNoMeCat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Spain,Ireland,Germany,Germany,Germany,Switzerland,Switzerland,Belgium,Switzerland,Sweden,France,Netherlands,Netherlands
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 3318634.08
EU funding (EUR): 3318634.08
Participants: 15
Project status: CLOSED

Transition metal catalysts are formidable tools towards greener chemistry, allowing for low-waste, energy-efficient, and selective reactions. However, the noble metals (Ru, Os, Rh, Ir, Pd, Pt) that are currently most common in homogeneous catalysts suffer from high toxicity and environmental impact in addition to their scarcity and ensuing high cost. First-row metals (Mn, Fe, Co, Ni, Cu) are emerging as environmentally benign alternatives, but to this day rarely equal the performance of their noble counterparts. The NoNoMeCat network aims at providing excellent and structured interdisciplinary training to a generation of young researchers in the field of Non-Noble Metal homogeneous Catalysis who will push the boundaries of the field in terms of catalyst stability, selectivity, mechanistic understanding, and scalability. These challenges are addressed in three areas of high fundamental and practical significance: the oxidation of hydrocarbons, the formation of new C-X bonds (C-C, C-N) bonds through cross-coupling reactions, and clean energy production. NoNoMeCat will enrol 14 Early Stage Researchers (ESRs) who will receive structured training in experimental and theoretical aspects of non-noble metal chemistry as well as transferable skills such as research integrity, scientific communication and public outreach. Tight integration of non-academic partners will expose all ESRs to aspects of both fundamental interdisciplinary research and industrial application, paving the way for long-standing intersectorial collaborations.

Keywords: first row transition metals,organometallic chemistry
Development and Evolution of Colour Patterns in Danio species (DanioPattern)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-11-01
End date: 2022-10-31
Duration (months): 72.0
Total project cost (EUR): 2250000.0
EU funding (EUR): 2250000.0
Participants: 1
Project status: CLOSED

Colour patterns are prominent features of many animals and have important functions in communication such as camouflage, kin recognition and mate selection. Colour patterns are highly variable and evolve rapidly leading to large diversities even within a single genus. As targets for natural as well as sexual selection, they are of high evolutionary significance. The zebrafish (Danio rerio), a vertebrate model organism for the study of development and disease, displays a conspicuous pattern of alternating blue and golden stripes on the body and on the anal- and tailfins. Mutants with spectacularly altered patterns have been analysed, and novel approaches in lineage tracing have provided first insights into the cellular and molecular basis of colour patterning. These studies revealed that the mechanisms at play are novel and of fundamental interest to the biology of pattern formation. Closely related Danio species have very divergent colour patterns in body and fins offering the unique opportunity to study development and evolution of colour patterns in vertebrates building on the thorough analysis of one model species. Our research in zebrafish will explore the basis of direct interactions between chromatophores mediated by channels and junctions. We will investigate the divergent mode of stripe formation in the fins and the molecular influence of the cellular environment on chromatophore interactions. In closely related Danio species, we will investigate the cellular interactions during pattern formation. We will analyse transcriptomes and genome sequences to identify candidate genes providing the molecular basis for pigment pattern diversity. These candidate genes will be tested by creating mutants and exchanging allelic variants using the CRISPR/Cas9 system. The work will lay the foundation to understand not only the genetic basis of variation in colour pattern formation between Danio species, but also the evolution of biodiversity in other vertebrates.

Keywords: danio species,zebrafish,biodiversity,pigmentation,chromatophore,melanophore,cell cell,interaction
3D Advanced Metrology and materials for advanced devices (3DAM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Research and Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Germany,Israel,Ireland,Hungary,Belgium,Switzerland,France,France,France,France,Netherlands,Netherlands,Denmark,United Kingdom
Call: Semicondutor Process, Equipment and Materials (H2020-ECSEL-2015-1-RIA-two-stage, 2015)
Start date: 2016-04-01
End date: 2019-03-31
Duration (months): 36.0
Total project cost (EUR): 23055897.5
EU funding (EUR): 6463826.63
Participants: 19
Project status: CLOSED

The objective of the 3DAM project is to develop a new generation of metrology and characterization tools and methodologies enabling the development of the next semiconductor technology nodes. As nano-electronics technology is moving beyond the boundaries of (strained) silicon in planar or finFETs, new 3D device architectures and new materials bring major metrology and characterization challenges which cannot be met by pushing the present techniques to their limits. 3DAM will be a path-finding project which supports and complements several existing and future ECSEL pilot-line projects and is linked to the MASP area 7.1 (subsection More Moore). Innovative demonstrators and methodologies will be built and evaluated within the themes of metrology and characterization of 3D device architectures and new materials, across the full IC manufacturing cycle from Front to Back-End-Of-Line. 3D structural metrology and defect analysis techniques will be developed and correlated to address challenges around 3D CD, strain and crystal defects at the nm scale. 3D compositional analysis and electrical properties will be investigated with special attention to interfaces, alloys and 2D materials. The project will develop new workflows combining different technologies for more reliable and faster results; fit for use in future semiconductor processes. The consortium includes major European semiconductor equipment companies in the area of metrology and characterization. The link to future needs of the industry, as well as critical evaluation of concepts and demonstrators, is ensured by the participation of IMEC and LETI. The project will directly increase the competitiveness of the strong Europe-based semiconductor Equipment industry. Closely connected European IC manufacturers will benefit by accelerated R&D and process ramp-up. The project will generate technologies essential for future semiconductor processes and for the applications enabled by the new technology nodes.

Keywords: metrology,characterization,materials
Mobility Urban Values (MUV)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Finland,Belgium,Belgium,Netherlands,Denmark,Portugal,Luxembourg,Portugal
Call: New ways of supporting development and implementation of neighbourhood-level and urban-district-level transport innovations (H2020-MG-2016-Two-Stages, 2016)
Start date: 2017-06-01
End date: 2020-05-31
Duration (months): 36.0
Total project cost (EUR): 3992625.0
EU funding (EUR): 3992625.0
Participants: 15
Project status: CLOSED

MUV (Mobility Urban Values) levers behaviour change in local communities in an entirely novel approach to reducing urban traffic. Rather than focus on infrastructure, it raises citizen awareness on the quality of the urban environment to promote a shift towards more sustainable and healthy mobility choices. MUV solutions are co-created and validated with learning communities in six diverse urban neighbourhoods – Buitenveldert in Amsterdam (NL), Sant Andreu in Barcelona (ES), Muide/Meulested in the harbour of Ghent (BE), the historic district of Fundao (PT), Jätkäsaari in Helsinki (FI) and the "Centro Storico" of Palermo (IT) – and extended to additional communities through open calls to join the network and adopt the MUV approach. MUV's technological ecosystem integrates three components: a mobile and wearable app, a distributed network of environmental monitoring stations (co-designed with local maker communities) and a scalable cloud platform to collect, aggregate and analyse data. The massive amount of data collected throughout MUV communities feeds local planning and policy-making processes to develop frugal and effective urban mobility solutions. Creativity and artistic design maximize local impact and the diffusion of project results beyond the communities directly involved. MUV’s ground-breaking approach thus achieves sustainable mobility through a blend of methods: co-creation, awareness raising, gamification, reward systems, new forms of communication, artistic design, ICT and data science, additive manufacturing, and open governance. Rather than embark in investments with long and uncertain paybacks, MUV empowers communities to better translate citizen needs into new solutions, engaging end-users throughout the process to prevent the risk of low take-up. Real impact is measured with an evidence-based approach to maximize economic viability and Social Return On Investment (SROI) and drive replicability and the scaling up and out of MUV solutions.

Keywords: co creation,co design,behavioural design,cloud technologies,data science,data visualization,game design,geomarketing,guerrilla marketing,mobility management,policy making,service design
FREE the MIND: the neurocognitive determinants of intentional decision (FREEMIND)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2023-02-28
Duration (months): 72.0
Total project cost (EUR): 1487908.0
EU funding (EUR): 1487908.0
Participants: 1
Project status: SIGNED

Acting based on intention is a fundamental ability to our lives. Apple or orange, cash or card: we constantly make intentional decisions to fulfil our desires, even when the options have no explicit difference in their rewards. Recently, I and others have offered the first evidence to support that intentional decision and externally guided decision share similar computational principles. However, how the brain implements these principles for intentional decision remains unknown. This project aims to establish a multilevel understanding of intentional decision, spanning from neurons to brain networks to behaviour, through a powerful combination of novel paradigms, cutting-edge brain imaging, and innovative methods. Central to my approach is formal computational modelling, allowing me to establish a quantitative link between data and theory at multiple levels of abstraction. Subproject 1 will ask which brain regions encode intentional information, when intentional processes occur, and how neurochemical concentration influences intentional decision. Subproject 2 will focus on theoretically predicted changes in intentional decision under behavioural and neural interventions. I will use brain imaging and brain stimulation to test the flexibility of intentional decision within individuals. Subproject 3 will launch the largest study to date on intentional decision. I will characterize individual differences in intentional decision from 2,000 representative samples. I will then investigate, with high statistical power, the contributions of neurochemistry and brain microstructure to individual differences in intentional decision. This project premises to establish the first neurobiological theory of intentional behaviour, and provide mechanistic understanding of its changes within and between individuals. The new theory and innovative methodology will open further research possibilities to explore intentional deficits in diseases, and the neural basis of human volition.

Keywords: intention,decision making,modelling,brain imaging
Safe and discrete gastrostomy tube for enteral feeding improving the delivery of nutrition and patient care. (GFeed)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Israel
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Patients unable to swallow for long time due to severe pathologies are fed by gastrostomy tubes that deliver nutrition and medications directly into the stomach. GFeed provide a discrete solution for initial placement, replacement, and complete removal of enteral feeding device that overcome most of the shortcomings of currently used tubes. The semi-rigid internal bumper prevents accidental dislodgment and it is safer for the stoma opening. A disposable insert placed inside the feeding port delivers the nutrition into the stomach. This is replaced every 1-2 weeks, avoiding clogging and making the tube cleaner and more hygienic. The internal bumper is conceived to dismantle in small parts that are naturally expelled from the body for trauma free-removal. G-Feed complies with EU future challenge to face impairments due to ageing population and to reduce the length of hospital stay, that is driving the demand of enteral feeding devices in alternate care and homecare settings. The global market of PEG tubes, replacement tubes, and other gastrostomy tubes is valued $510 million in 2015 and growing at a CAGR of 5.5%. Over 17 million PEG tube procedures are expected in Europe and US by 2020. The initial placement kit is addressed to gastroenterology departments in hospitals and clinics, while the disposable insert is distributed to pharmacies and sold directly to the end-users, namely the enteral fed patients. GFeed adoption by gastroenterologist and their patients will enhance patient comfort and improve the delivery of nutrition by avoiding tube clogging, and will decrease healthcare cost by reducing the need for emergency intervention for displacement and/or complication. During phase 1, a feasibility study will be carried out, as well as the planning of clinical trials in chronic animal and human patient that will be performed during the whole innovation project, to gain the validation needed to bring the product to the commercialization.

Keywords: gastrostomy tube,low profile,enteral feeding,disposable,nutrition,feeding tube,gastroenterelogy
The autonomous floral pathway: a WIndow to Study the tight link between non-coDing RNA and chrOMatin regulation (WISDOM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

My Fellowship will explore the interconnection between non-coding RNA and chromatin regulation. Building on a detailed mechanistic base, I will capitalize on the recent proteomic identification of a stable complex FLD/SDG26 by my host lab, which plays a central role in the co-transcriptional silencing of the Arabidopsis floral repressor locus FLC. This protein complex is central to a mechanism determining the quantitative expression level of FLC, and thus the reproductive strategy of the plant. However, these activities also regulate many other targets in the Arabidopsis genome and the conserved nature of the components suggests the deeper understanding gained from this study will be important generally across all eukaryotes. FLD is a histone demethylase with specificity for H3K4; SDG26 is a SET domain protein likely to methylate histones and other proteins, but whose specificity is currently unknown. The splicing and alternative processing of FLC antisense non-coding transcript, COOLAIR, is essential for the repression of FLC transcription. However, how the processing of COOLAIR controls sense transcription remains elusive. My proposal aims to: 1) test the hypothesis that the FLD/SDG26 complex, triggered by FCA/FY-mediated proximal polyadenylation of COOLAIR, delivers a specific chromatin environment, which represses transcriptional output: and 2) explore the missing link between FCA/FY-mediated proximal polyadenylation of COOLAIR and chromatin regulation by FLD/SDG26 complex. My proposal involves interconnections between genetics, biochemistry and molecular biology, enabling me to develop a broader experimental skillset. It directly contributes to the action’s goals to: improve my creative potential and competences through international mobility and advanced training in technical and transferable skills; enhance collaborative and contact networks for both myself and my host lab through academic and public engagement; and drive substantial career development.

Keywords: arabidopsis,epigenetics,flowering time,antisense non coding rna,histone modification,transcription
Enhancing Food Security in AFRIcan AgriCULTUral Systems with the Support of REmote Sensing (AfriCultuReS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Developing comprehensive and sustained global environmental observation and information systems
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Spain,South Africa,Ethiopia,Greece,Tunisia,Sweden,Netherlands,Ghana,United Kingdom,United Kingdom,Mozambique,Niger,Rwanda,Kenya
Call: Earth observation services for the monitoring of agricultural production in Africa (H2020-SFS-2017-1, 2017)
Start date: 2017-11-01
End date: 2022-10-31
Duration (months): 60.0
Total project cost (EUR): 8531533.2
EU funding (EUR): 8531533.2
Participants: 18
Project status: SIGNED

AfriCultuReS – Enhancing Food Security in AFRIcan AgriCULTUral Systems with the Support of REmote Sensing - aims to design, implement and demonstrate an integrated agricultural monitoring and early warning system that will support decision making in the field of food security. AfriCultuReS will deliver a broad range of climatic, production, biophysical and economic information, for various regions in Africa. AfriCultuReS will apply geospatial science to sustainable agricultural development, natural resource management, biodiversity conservation, and poverty alleviation in Africa. AfriCultuReS, supported by the GEO Secretariat, will involve all key players of AfriGEOSS, GEOGLAM, SIGMA, ARTEMIS, African Drought Observatory and other initiatives as well as partners representing the diversity of African agricultural systems, in an effort to push forward the services provided by current systems, with innovative fusion of data from multiple sources (EO, in-situ, citizen-based crowdsourcing, climate services and weather, crop models) in a vertical manner. Crop yield and biomass prediction models will be enhanced through the fusion of EO data and climate models, emphasizing the use of the complementary sensors of the EU Sentinels constellation. Geospatial products will be combined in a spatial Decision Support System (DSS) to enrich decision making and risk assessment. The geo component of the DSS will be compliant with the GEO’s interoperability standards, allowing its integration with the current services of the GEOSS Common Infrastructure. The African partners and collaborating networks will be essential for local training and promoting further use of the project tools. Social innovation will be used to increase the number of involved stakeholders and to boost the flow of information in a user-friendly manner. The final target will be to produce a web tool that will support early decision making for the stakeholders of African food production.

Keywords: food security,africa,earth observation,climate services,decision support system,sigma,gmes and africa