Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
NANOMEDICINE FOR ORGAN TRANSPLANTATION TOLERANCE (PHOENIX) (PHOENIX)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Italy,France,Ireland,Spain
Call: Pre-clinical development of the next generation of immunotherapies for diseases or disorders with unmet medical needs (HORIZON-HLTH-2022-DISEASE-06-two-stage, 2022)
Start date: 2023-04-01
End date: 2026-09-30
Duration (months): 42.0
Total project cost (EUR): 4893418.25
EU funding (EUR): 4893418.25
Participants: 5
Project status: SIGNED

PROBLEM: Today, organ transplant medicine is limited by life-long immunosuppression and vulnerability to infections, malignancies and cardiovascular diseases, and by a 20% rate of long-term graft failure. SOLUTION: PHOENIX reprograms the local immune micro-environment around a graft organ, inducing long-term transplant tolerance without broader systemic immunosuppression. FOUNDATIONS: Our expert teams have already discovered novel peptide-MHC complex-based nanomedicines for the treatment of autoimmune diseases. This project will transform, deploy and validate this nano-technology platform for transplant medicine. We have unique expertise in kidney and liver murine transplant models as well as liver transplantation in pigs and have established a molecular engineering pipeline for immune-protein synthesis to enable future clinical translation. Extensive clinical-trial expertise will enable us to progress efficiently from this project towards the clinic. WORKPLAN: We are designing and building a unique nanomedicine which delivers ubiquitous or self-antigens - common to all humans – that will redirect the host immune response against the graft toward regulation and tolerance development. These medicines will be demonstrated in murine and porcine models, laying the foundation for human clinical trials immediately post-project. SUMMARY: This project combines innovative multi-disciplinary approaches, building on a proven foundation, to deliver a novel therapy which will have a transformative positive effect on organ transplant patients and healthcare.

Keywords: immunology,nanotherapy,organ transplant,reprogramming the immune response
NOVEL CO2-BASED ELECTROTHERMAL ENERGY AND GEOLOGICAL STORAGE SYSTEM - CEEGS (CEEGS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Spain,Greece,Belgium,Germany,Portugal,Malta,Estonia,Romania,Türkiye,Bulgaria,Slovenia,Czechia,Italy,Serbia,Croatia,Sweden,Poland,Ireland,Ukraine,Hungary
Call: Next generation of renewable energy technologies (HORIZON-CL5-2021-D3-03, 2021)
Start date: 2022-11-01
End date: 2025-10-31
Duration (months): 36.0
Total project cost (EUR): 2992060.0
EU funding (EUR): 2992060.0
Participants: 31
Project status: SIGNED

CEEGS (CO2 based electrothermal energy and geological storage system) is a cross-sectoral technology for energy transition, with a renewable energy storage system based on the transcritical CO2 cycle, CO2 storage in geological formations and geothermal heat extraction. It is a highly efficient, cost-effective, and scalable (small-to large-scale) concept for large-capacity renewable energy storage. Extended capacity is obtained due to the underground system. It can be integrated into the grid, heating and cooling districts and industries. It also has the capacity for partial CO2 sequestration. The main objective of the project is to provide scientific proof of the techno-economic feasibility of the technology, raising the current low TRL 2 to TRL 4 by addressing gaps in the interface between surface transcritical cycle and the subsurface CO2 storage. CEEGS follows a 3-phase approach: i) From theoretical principles to models, simulations and processes in which advanced numerical simulations integrate reservoir behaviour, wellbore design and surface plant design; ii) From models and simulations to systems/experimental verification addressing CEEGS integration and efficiency in energy systems, with digital functional and laboratory models developed and components validated with results from the CO2 pilot-scale projects and; iii) Social, economic and sustainability assessments where social acceptance studies, LCA and TEA tools evaluate impacts and concept deployment with renewables, hard-to-decarbonise industries, district heating and cooling, or in grid balance. The project is completed with WP1 for coordination and WP7 for results dissemination and exploitation. The project integrates the knowledge and networks for a successful implementation in 3 years with a consortium with partners from 5 EU countries, with multidisciplinary skills on energy systems, energy storage, geology, geothermal systems and CO2 geological storage

Keywords: energy storage renewables integration thermoelectric transcritical co2 co2 sequestration
Biological Isotopy of Lithium in Littoral Zones (SeaLi2Bio)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 3182574.0
EU funding (EUR): 3182574.0
Participants: 2
Project status: SIGNED

Lithium (Li) is key in the energy transition and massively used to produce mobile devices and electrical vehicles. Yet its current consumption rate exceeds its river flux to the ocean, and it is poorly recycled, while Li excess is toxic for aquatic life and humans. Although concentrations of Li and its isotopes have been measured in coastal waters, at river outlets, to study continental chemical weathering and climate controls, Li monitoring has been occasional. Moreover, bias caused by anthropogenic inputs is not quantified. Combining a novel isotopic methodology with ecotoxicology and biology approaches, SeaLi2Bio will first determine and understand the littoral Li contamination sources, flux and controls, and quantify its current contribution to the Li cycle. Plankton, macroalgae and bivalves will act as long-term bioindicators at reference sites located along urbanisation gradients. The biological controls of Li isotopes will be determined by aquaculture of model organisms, over a range of representative environmental and metabolic conditions, and confronted to in situ measurements. Upscaling from regional to global scale will be achieved with a multivariate statistical model accounting for geospatial data on watershed characteristics, population density and socioeconomic parameters. This project will also anticipate future environmental and health issues caused by Li contamination, focusing on the North Chile coast where Li levels are known as the highest, and using innovative health-monitoring tools (Cu-Zn isotopes). Finally, the evolution of Li contamination will be simulated at the continental and global scale, following scenarios of energy transition impacting differently Li demand and waste. By disentangling the factors of Li contamination from the natural background, SeaLi2Bio will assemble a first robust reference for a global issue tied to the history of climate and its future evolution in response to reduction of fossil fuels use.

Keywords: non conventional isotopes,trace metals,environment
Single-shot, ultrashort laser pulse characterization based on the dispersion scan technique (SISHOT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden,Portugal
Call: EIC Transition Open 2021 (HORIZON-EIC-2021-TRANSITIONOPEN-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 2071778.75
EU funding (EUR): 2071778.0
Participants: 2
Project status: SIGNED

Ultrashort laser pulses are prominent enabling tools in countless advanced applications, ranging from fundamental research to medical and industrial use. However, straightforward characterization of ultrashort laser pulses remains a nontrivial task. The proposed project (acronym: SISHOT) focuses on the development of advanced ultrashort laser pulse characterization based on the dispersion scan (d-scan) technique. We propose two d-scan implementations, named s-shot and d-shot, capable of characterizing ultrashort laser pulses in single-shot operation. Single-shot characterization techniques are particularly appealing because they can measure the temporal profile of individual laser pulses without artefacts, often originating from averaging. The proposed techniques can directly link the measured pulse parameters to the outcome of experiments for every laser shot as well as give immediate, real-time feedback to the adjustment and optimisation of any ultrashort pulse laser. In comparison to the competitors, our instruments are easier to use and the measurements are more intuitive to interpret. Within the project, the s-shot will be lifted from TRL4 to TRL7 and the d-shot from TRL7 to TRL9. We have identified the most important markets for ultrashort pulse characterisation. The s-shot will address the important scientific market at the laser wavelength of 800 nm and the d-shot will focus at the wavelength of 1030 nm, which is more relevant to medical and industrial applications. The project builds on the outcome of the previously funded ERC POC project, SISCAN. It is headed by Cord L. Arnold, assoc. prof. at Lund University in Sweden, and Rosa Romero, CEO of the deep-tech company, Sphere Ultrafast Photonics, located in Porto, Portugal. All team members have been working with the d-scan technology for many years in different collaborations, including two common ERC POC projects. Many of them are co-founders of Sphere and co-inventors of the patents the project builds on.

Keywords: laser pulse characterization,ultrashort pulse lasers,dispersion scan
Measuring the energetic cost of generating biological order (AsterFields)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 289407.84
EU funding (EUR): 289407.84
Participants: 2
Project status: SIGNED

Every second, millions of cells go through mitosis in the human body, a process dividing the cells and their genetic content. In eukaryotic cells, a cytoskeletal structure named the spindle apparatus is responsible for physically separating the duplicated chromosomes. The self-organization of filaments (microtubules) and associated molecular motor proteins shape this structure. For decades, the dynamics of active cytoskeletal matter have been investigated both in vivo and in vitro. However, a comprehensive quantitative understanding of the dynamics of the constituents and their energy budget remains elusive. This action aims to investigate the non-equilibrium dynamics of contractile self-organizing active cytoskeletal material through energy and order quantification and to establish a field-based model to describe energetics and dynamics in three dimensions.

Keywords: active matter,biophysics,self organization,biological dynamics
Pyrolytic Renewable Approach for Hydrogen and Carbon Production: Efficient Transformation of Biogenic Wastes into Hydrogen and High-Value Solid Carbon for New Industrial Value Chains (PYRAH2)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Spain,France,Luxembourg,Portugal,Italy,Denmark
Call: Innovative hydrogen and solid carbon production from renewable gases/biogenic waste processes (HORIZON-JU-CLEANH2-2025, 2025)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 11086536.24
EU funding (EUR): 7958550.6
Participants: 12
Project status: SIGNED

The PYRAH2 project tackles Europe’s need for sustainable and cost-effective hydrogen and carbon-based products, amid climate change and increasing energy demand. Existing hydrogen production methods — like steam methane reforming, coal gasification, and water electrolysis — depend on fossil fuels or are too costly and energy-intensive, and none recover solid carbon as a valuable co-product. PYRAH2 offers an integrated platform that converts biogenic waste and renewable gases into high-purity hydrogen and solid carbon through a four-stage process: autothermal gasification and syngas conditioning, syngas biomethanation, CO2 separation, and plasma-assisted methane pyrolysis. This process transforms diverse organic waste into bioproducts and carbon-negative energy carriers, surpassing current technologies. The process is based on technologies developed by leading EU startups (WtE, Terrawatt, Plenesys) and world-class research teams at Polimilano and DTU, covering all steps from biowaste valorization to biomethane splitting with high-pressure plasma at 1200°C. It produces zero-emission hydrogen and solid carbon, avoiding 9 to 14 kg CO2 per kg of H2. This route achieves over 90% carbon recovery, converting solid carbon into an industrial product, reducing waste, and improving economic viability. Industrial partners like GoodYear and ArcelorMittal will test this output in tyre and steel production. In order to ensure TRL advancement from 5 to 7, a full-scale pilot will be built at the site of chemical industry HyChem, with bioenergy-specialized EPC company Necta leading the plant assembling and commissioning. The PYRAH2 valorisation pathway is fully aligned with Europe’s policy objectives on sustainability and competitiveness, including RED III, the EU Hydrogen Strategy and the Fit for 55 package. It provides a circular, scalable, and competitive solution for advancing a sustainable model of hydrogen production.
Understanding the nature of the low energy excess in cryogenic detectors to discover light dark matter (LEGENDRE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Canada
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-12-01
End date: 2025-11-30
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 2
Project status: SIGNED

Although numerous evidences from cosmology and astrophysics indicate the existence of Dark Matter (DM), which constitutes about 85% of the whole matter in the universe, its intrinsic nature is still today one of the major mysteries in physics. The lack of the discovery of the so-called Weakly Interacting Massive Particles is shifting the attention to additional, well-motivated, theoretical models that predict DM particles with lower masses. To test these, new extremely sensitive direct detection DM experiments have been developed, which are now starting to explore energies so low that were considered impossible to reach until just a couple of years ago. But these experiments are now observing unpredicted excesses of events, mostly incompatible with a DM signal, in the previously unexplored low energy region. And this irreducible background dramatically limits their sensitivity to new low-mass signals. In this project I propose a novel analysis strategy that will lead to the understanding of the nature of the low energy excess, providing invaluable information to the European and international experiments working on this field. I will also lead and coordinate the data taking campaign necessary for a positive outcome, which will employ world-leading sensitive cryogenic devices developed by the SuperCDMS collaboration, installed in the Cryogenic Underground Test at the world-class underground SNOLAB laboratory. The project will be completed in a leading research group, to which I will bring knowledge on how to efficiently operate a cryogenic detector as well as on how to run a dilution refrigerator. This work will extend my experience, show my research competencies and independence, enhancing the development of my career as a researcher.

Keywords: astroparticle physics,cryogenic detector,data analysis
Curing Blindness with stem cells: Development of a novel off-the-shelf regenerative therapy for restoring sight after Limbal Stem Cell deficiency (LSCD). (STE-001)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Finland
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Limbal Stem Cell Deficiency (LSCD) is a form of corneal blindness, mostly affecting young and working-age people. The current treatment option consists of transplanting limbal stem cells from the healthy eye but cannot be used for over half of the patients since they are blind in both eyes. StemSight has developed STE-001, a highly innovative treatment method to restore vision in patients with LSCD using induced pluripotent stem cell-derived limbal stem cells. The therapeutic cells are transplanted onto the cornea on top of a biodegradable carrier membrane, allowing trace-free regeneration of the ocular surface and restoring vision. It is a one-time surgical treatment for LSCD and provides life-long restoration of limbal stem cell function thereby reducing patient pain and giving them a normal life. With the help of the EIC accelerator, StemSight will complete product optimization, perform clinical studies & market validation, & launch our product for market and scale-up activities.

Keywords: cell therapy,cell biology,cornea,blindness
A NOVEL NON-INVASIVE DNA METHYLATION TEST FOR MELANOMA (MitraTest)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator Open 2025 (HORIZON-EIC-2025-ACCELERATOR-02, 2025)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 3570000.0
EU funding (EUR): 2499000.0
Participants: 1
Project status: SIGNED

Early cancer detection is a key to improve survival rates. For melanoma the survival falls from >98% at Stage 1 to 22% at Stage 4. Currently, skin biopsy is the only method of melanoma detection. It is an expensive and invasive procedure. Our patented technology, is a combination of a unique non-invasive tape strip skin sample collection technique and proprietary DNA methylation panel specific for melanoma. This will allow quick and inexpensive testing for melanoma at GP level and as an at-home test kit. Our proof of concept study with Guy’s Hospital (UK) showed over 95% specificity and 85% sensitivity in detecting melanoma compared to standard biopsy procedures. Mitra Bio is a female-led team of 6 scientists and business developers with experience in building diagnostics platforms. We aim to improve melanoma detection and reduce melanoma health and economic burden, which currently results in 15K deaths/year in the EU.

Keywords: cancer,melanoma,skin disease,dna methylation,biopsy
Development of an AI and block-chain enabled Digital Medical Twin (AIDT) based clinical trials recruitment platform for precision oncology. (Akkure)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Akkure Genomics are developing world’s first AI and ML enabled GDPR and HIPPA compliant patient recruitment platform which precisely connects right patients with right clinical trials in real time by processing both structured and unstructured genomics, physiological and clinical data (EMR) across multiple data-sources. Akkure utilize dynamic AI enabled Digital Medical Twins (AIDMT) to maintain dynamic datasets for individual patient and identify target populations before trial. It leverages upon ‘Smart Contracts’ for continuous consent and real-world data (RWD) access to ensure patient security of access, control & ownership of clinical data. AIDT offers the most comprehensive real-time digital representations of patient data, ensuring precise and personalised insights for individual patient

Keywords: precision clinical trials,insilico digital twin,genomics,ai,blockchain,clinical trials recruitment,drug discovery