Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Fabrication and Electron Transport Study of Nanowire based Quantum Devices (NANOQUANTUMDEVICES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Hungary
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-04-01
End date: 2012-03-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The investigation of the transport properties of nanoscaled objects is a strongly expanding field of nowadays solid-state physics, it attracts increasing attention either in applied science due to the potential in future applications or in basics research due to exciting quantum effects on the nanoscale. Semiconducting nanowires (NW) are single crystals with a typical diameter of 10-100nm and length of 5-10microm. Fabricating metallic leads to NWs, devices can be produced, where the electron density can be strongly varied by gates and the transport can be explored from the quasi-ballistic to the quantum dot regime. Due to their exceptional properties (e.g. band structure engineering, possibility to contact them with ferromagnetic (F), superconducting (S) leads, local gating), NW based devices open a new horizon in quantum transport. In order to be competitive in the field of experimental quantum electronics, it is essential to own sample fabrication facilities, which has not been available in the host institute. The main aim of this proposal is to set up the environment of device fabrication, which will be based on a Jeol scanning electron microscope equipped with lithography unit. The applicant will fabricate and investigate the low temperature transport properties of InAs NW based devices focusing mainly on spin injection from ferromagnetic leads and on F-S hybrid nanostructures. The fabrication facility will also support other ongoing quantum electronic projects.

Keywords: condensed matter physics,quantum transport,quantum dots,semiconductor nanowires,superconductivity,ferromagnetism,spintronics,low temperature transport
Uncovering the Mammalian Targeting Machinery for Tail Anchored Proteins (TA PROTEIN INSERTION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-12-01
End date: 2013-11-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Activation of the BCL2 oncogene underlies a wide variety of malignant transformations. BCL2 must be present on the membranes of both the mitochondria and the endoplasmic reticulum (ER) to carry out its role in protecting cells from cell death (apoptosis). To enable its anchoring to intra cellular membranes, BCL2 has a C-terminal hydrophobic tail in a unique topology shared by members of a large family of Tail Anchored (TA) proteins. In mammals hundreds of such TA proteins exist that serve diverse and essential functions on every intracellular organelle. Despite the great importance of these proteins for cellular function, the pathway for enabling their anchoring to membranes has remained unknown for many years. We have recently discovered the protein machinery required for insertion of TA proteins into ER membranes in an effective and membrane specific manner in yeast. However, the mammalian pathway is not fully characterized. Moreover, the proteins required for insertion of TA proteins into mitochondrial membranes in both yeast and mammals are completely unknown. This proposal aims at uncovering and characterizing the machinery responsible for inserting BCL2 and other TA proteins into membranes in mammals. We will take two approaches – in the first, the homologous machinery to the GET complex in mammalian cells will be explored and its affect on BCL2 localization will be studied. In parallel, we will screen for components of the cellular machinery required for insertion of TA proteins into the mitochondria using high-throughput microscopy based silencing screens in mammalian cells. The discovery of the molecular machinery guiding the sub-cellular fate of the dual-localized BCL2 oncogene, can serve as a tool for better understanding BCL2 functions and for controlling its anti-apoptotic activity. More importantly, characterizing the basic machinery required for TA protein insertion will shed light on a fundamental and little explored part of cell biology.

Keywords: cell biology,molecular biology,tail anchored proteins,endoplasmic reticulum,get complex,bcl2,rnai,silencing screen
Detection of Brain Abnormality (DEBRA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-04-01
End date: 2012-03-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Cerebrovascular disease (CVD) is a very significant health problem, especially in view of the increasing aging population. It is highly prevalent in diabetic populations and is also a major cause of dementia, individually or as an additive factor to other pathologies, such as Alzheimer’s. Therefore measuring disease burden, progression, and response to treatments is very important for patient management. MRI is currently the most widely used way to characterize in vivo the type and extent of brain lesions in CVD and has been used in several large neuroimaging studies. However, characterization of CVD has largely relied on qualitative, subjective, and not easily reproducible methods of human expert-based interpretation. Computer-based methods for measuring CVD offer great potential, since they are quantitative; reproducible, and particularly suitable for longitudinal studies monitoring disease progression and response to candidate treatments. Most methods have focused on the segmentation of Multiple Sclerosis lesions, whereas less attention has been given to brain lesion segmentation in elderly individuals and Alzheimer’s disease or diabetic patients. The project DeBrA (Detection of Brain Abnormality) includes the development and implementation of medical imaging techniques for measuring CVD and its change over time, from multi-parametric MR images by employing advanced 4-dimensional (space X time) segmentation methods based on pattern classification and statistical modeling. The goal is to determine whether the new methodology will provide more stable measurements of longitudinal change in CVD, compared to relatively more conventional methods and therefore increase the sensitivity of detecting subtle effects. Moreover, while the tools will be initially developed for measuring CVD, they will be made suitable to hold widespread potential for applications in other neuroimaging studies involving abnormality detection.

Keywords: medical image analysis,image segmentation,cerebrovascular disease,white matter lesion,infarct,mri,multiparametric imaging,pattern classification,statistical model,abnormality detection
Experimental verification of the mechanisms of shock waves acceleration of volcanic particles toward metal targets: a tool to understand shock waves hazard in explosive volcanic eruptions. (SPAEX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-04-15
End date: 2012-04-14
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Despite shock waves commonly occur during explosive volcanic eruptions, a number of issues concerning their generation and propagation is still object of debate in the scientific community and the associated hazard is downplayed in the risk assessment of active volcanic areas. Micrometric impact craters produced by volcanic ash particles were found on a steel basketball pole in one of the villages destroyed by the 1982 eruption of El Chichón volcano (Mexico). The velocities of impacts, calculated by analytical methods, showed typical shock waves values up to 980 m/s. The research topic outlined in this proposal is the experimental acceleration of volcanic particles of different size and mass toward steel targets by shock waves produced by a rapid decompression of a pressurized system (fragmentation bomb). Research questions to be answered are: a) which is the role of the gas phase in accelerating particles by the rapid expansion produced by a shock wave? b) Which is the role of particles’ size and/or mass in the acceleration mechanism? c) What is the importance of the impact angle in the magnitude of the craters produced? The results expected will contribute to a better understanding of the mechanisms of shock waves propagation during explosive eruptions and inspire further investigations to improve hazard mitigation strategies.

Keywords: shock waves,particles acceleration,metal targets,experiments
Between Family and Market: The Legal Regulation of Household Care Work in Globalizing Economies: Housewivery, Domestic Work, and Sex Work (CAREWORKFAMILYMARKET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-10-01
End date: 2013-11-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Women’s disproportional familial care responsibilities are widely understood to pose a challenge to women’s equality. In post-industrial economies, where the majority of women have entered the workforce, care responsibilities still limit women’s opportunities. A common ‘care solution’ is the redistribution of care work between women of different classes, ethnicities, and nationalities in the form of paid care services. Although this is hardly a new phenomenon, post-industrial globalizing economies give it new forms that evoke new regulatory challenges. My research is an inquiry into the relationship between family and market, focusing on four paradigmatic cases of women’s care work. The first is the prototype of care work: housewife’s work in the home. The other three are the main market reconfigurations of the prototype: paid domestic work, sex work, and mail ordered brides. Studying of the legal regulation of these four cases, I investigate the nature of the distribution of care along gender and class lines. Law operates in these ‘markets of care’ through a combination of regulatory tools. My project offers a cross-section of the legal system, elucidating the combined operation of different areas of law – family, welfare, employment, immigration, and criminal law– and their influence on markets for paid domestic/sex work. These areas of law are studied comparatively in three legal systems: U.S.A, United Kingdom, and Israel. All three are post-industrial, globalizing economies, but there are acute differences in the way they handle their welfare state, immigration policy, and legal regimes of prostitution. Through the study of this matrix of legal regulation, the research aims to uncover the institutional settlement of care responsibilities in liberal welfare states, one which holds the potential for significant redistribution of social and political power among members of households and classes alike.

Keywords: family law,employment law,welfare law,immigration law,criminal law,gender,care work,sex work,domestic work,distributive justice,informal markets,liberal welfare state,human trafficking
Impact of surgical and pharmacological interventions on fetal lung growth in pulmonary hypoplasia (INCREASELUNGGROWTH08)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-12-15
End date: 2012-12-14
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Pulmonary hypoplasia is a significant cause of perinatal death and occurs with an incidence of 15%. A common (1:2500 newborns) malformation resulting in hypoplastic lungs is congenital diaphragmatic hernia (CDH). Affected lungs have reduced and functionally altered airways and vessels, leading to respiratory deficiency and pulmonary hypertension in the neonatal period. Nowadays, prenatal fetoscopic endoluminal tracheal occlusion (FETO) can be offered in selected cases to prevent excess of pulmonary fluid and thus triggering lung growth. However, the procedure remains invasive with the main risk of premature rupture of the membranes and still 40% of affected neonates succumb, the majority due to persistent hypoplasia. Therefore, pharmacological agents, including vitamins, hyperoncotic agents and growth factors, have been proposed as an additional prenatal treatment approach to further improve postnatal outcome. Experimental section: We aim to investigate the potential of two important growth factors, VEGF and IGF-1, to stimulate lung growth in the nitrofen rat model for pulmonary hypoplasia, with particular interest on dosage, route and time-point of administration. If beneficial, the obtained results will provide a profound scientific basis for a pharmacological treatment modality that can be applied by fetoscopy or even via ultrasound-guided needle procedures in fetuses affected by CDH. Clinical section: Few centers, including the former host institution, offer FETO and termination of affected pregnancies is still widely performed. We plan to perform advanced clinical evaluation of afflicted pregnancies in the framework of a specialized outpatient clinic in Graz, Austria, in close collaboration with the former host institution in Leuven, Belgium, with regards to transfer of patients and data. Advancing the national awareness for prenatal therapeutic options will complete our intentions to improve postnatal survival and morbidity in babies affected by CDH.

Keywords: pulmonary hypoplasia,congenital diaphragmatic hernia,fetal surgery,growth factors,vascular endothelial growth factor,vegf,insulin like growth factor,igf
Automorphic forms and L-functions (AUTOMORPHIC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Hungary
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-05-01
End date: 2012-04-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Automorphic forms and L-functions have a long tradition in number theory which can be traced back to the classical work of Jacobi, Dirichlet, and Riemann. They make hidden symmetries of integers visible and provide deep links to other branches of mathematics such as algebraic geometry, combinatorics, representation theory, ergodic theory, dynamical systems, and mathematical physics. Gergely Harcos, the researcher of the present proposal, intends to apply methods from spectral theory and representation theory to establish new bounds for automorphic forms and L-functions. Such bounds play a key role in the solution of difficult Diophantine problems addressing equidistribution phenomena, and they also shed light on deep conjectures such as the Grand Riemann Hypothesis. Gergely Harcos returned to Europe in 2006 with a Marie Curie Intra-European Fellowship after a decade of successful work in the United States. He fulfilled several goals set out in his earlier proposal. He introduced a new line of mainstream research at Rényi Institute and initiated a regular seminar on automorphic forms in order to build a collaborative network. He designed and taught new courses in number theory at Central European University for an international audience which further added to his impact. Gergely Harcos will stay at the host where he will be elected a permanent member soon. The present project serves as an organic continuation of his earlier Marie Curie proposal.

Keywords: number theory,automorphic forms,l-functions,subconvex bounds
A longitudinal multilevel investigation of the influence of top management team, board of directors and CEO characteristics on firm strategy and performance of European MNCs (GOVMNC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-08-05
End date: 2012-08-04
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The aim of this research projects is to investigate the influence of top managers and board of directors on firm strategy and performance over time. While previous research has established that the characteristics of the executive team and the corporate board have a significant impact on various aspects of firm strategy, little is done to investigate such influence over time. Furthermore, most previous research is conducted on North American samples, largely ignoring the influence of country level cultural and institutional factors. Based on a comprehensive sample of world largest 2000 MNCs and their internationalization strategies over a twenty year period (1988-2007), this project aims at investigating the extent to which heterogeneity in top managers and corporate directors characteristics influence firm international activities such as international strategic alliances, international M&As and establishment of foreign subsidiaries. By applying multilevel theory and method, this project will explore how such relationships vary across different cultural contexts and what are the factors that determine such differences. The project findings will have important implications for European MNCs as they will allow a comparison with American and Asia MNCs and to draw conclusion for similarities as well as differences in corporate elites’ characteristics and firm strategies among European countries.

Keywords: top management teams,board of directors,ceo,upper echelons,international strategy,company performance,international economics,management of enterprises,european mncs,longitudinal,multilevel
Luminescently doped nanoparticles. Strategies for improving sensitivity in luminescence assays and implementation in microarray formats. (NANOLUM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-09-01
End date: 2012-08-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

This project aims to take advantage of polymeric nanoparticles as a tool for improving sensitivity and performance of (chemi)luminiscence based assays. For instance, highly emissive red/near-infrared (NIR) dyes and long-lifetime luminophores like Ru(II) complexes will be combined in nanoparticles for increased emission efficiencies, better discrimination from background interferences and improved photostability. These beads will be employed for labelling antibodies to be used in immunoassays. Several strategies will be explored, taking advantage of FRET processes, (chemi)luminescence of Ru(II) complexes and high emission efficiencies of red/NIR boron-dipyrromethene (BODIPY) dyes. Additionally, the use of molecularly imprinted polymers (MIPs) as synthetic analogues of antibodies will be explored for the selective recognition and fluorescent indication of analytes containing carboxylic groups. The fabrication of the MIP fluorescent probes in a nanoparticle or core-shell nanoparticle form is expected to improve response time of the sensor and binding of the target analyte, and to allow ratiometric measurements or indication via energy transfer processes. The main task will cover the synthesis of luminescent molecular probes, nanoparticles and luminescently doped nanoparticles and MIPs, with a complete physical and photophysical charaterization. These particles will be implemented in a final stage onto microarray based technologies for monitoring the presence of certain toxins and antibiotics in water and aquaculture products.

Keywords: organic chemistry,analytical chemistry,aquaculture,water quality monitoring,photochemistry,luminescent probes,nanoparticles,molecularly imprinted polymers,microarrays,immunoassays
Demonstration & Deployment of a Commerical Scale Wave Energy Converter with an innovative Real Time Wave by Wave Tuning System (WAVEPORT)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable electricity generation
Action type: Collaborative project
Countries involved: United Kingdom,Portugal,United Kingdom,Spain,Norway,United States
Call:  (FP7-ENERGY-2008-TREN-1, 2008)
Start date: 2010-02-01
End date: 2014-07-31
Duration (months): 54.0
Total project cost (EUR): 9146412.4
EU funding (EUR): 4591850.5
Participants: 6
Project status: CLOSED

In the Atlantic arc from Iceland to Portugal, Europe has some of the best natural wave resources in the world; with the total potential European ocean wave power estimated to be in the range 150 -240 TWh per annum. The main barrier to wave energy expansion is the lack of a large, commercial-scale demonstration of the technology. In addition, the efficiency of devices is limited and needs to be improved. The WAVEPORT project aims to address this shortfall by demonstrating a large scale grid connected, 600kW peak generator rated, point absorber Wave Energy Converter - for which a smaller scale prototype has already been tested. WAVEPORT will also expedite the development of alternative devices by installing a ten port “open platform” 1.5MW rated underwater substation pod for the validation of future wave energy converters. To address the need for improved efficiency; a novel Real-Time Wave-by-Wave tuning system will be developed and demonstrated. Our aims are: - Reduce the capital infrastructure cost of the WEC device to less than €2000/kW by 2020. - Accelerate the development of a wavefarm site within the Santona site in Spain, to 90 MW by 2020 generating over 500 GWh per annum, offsetting approx 215,000 tonnes of CO2 per annum - Accelerate the development of European wave farms to 0.97 GW by 2020 generating over 6 TWh offsetting approx. 2.6 mT of CO2 per annum - Facilitating an “open platform” approach for utilities and WEC developers through the use of the Underwater Sub-Station Pod, further reducing the risks associated with investment in this technology - Reduce the cost of Wave energy generated electricity to 4.3 c€/kWh by 2020 - Improvement on the energy efficiency of wave energy devices by at least 35 % (loading factor to at least 75%) by utilising the Real-Time Wave-by-Wave tuning system. - Create 7600 jobs in the renewable energy sector over the period to 2020 by developing a European based wave energy industry worth €1.9 billion in cumulative sales.

Keywords: wave energy converter,powerbuoy,underwater substation pod,real time wave by wave tuning,deterministic sea wave prediction,quiescent period predictive control,active impedance matching system