Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Semiconductor-based Ultrawideband Micromanipulation of CAncer STEm Cells (SUMCASTEC)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Italy,France,France,United Kingdom,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2021-02-28
Duration (months): 50.0
Total project cost (EUR): 3978517.5
EU funding (EUR): 3978517.5
Participants: 7
Project status: CLOSED

SUMCASTEC explores radically new approach for cancer stem cells (CSCs) real time isolation (i.e. within minutes vs current 40 days) and neutralization. A novel micro-optofluidic lab-on-chip (LOC) platform will be developed through a joint and iterative effort by biologists, clinicians and engineers. For the first time, a single LOC will be capable of delivering ultra-wide broadband radiation to compare cell spectral signatures, image subcellular features, and hence modulate CSCs microenvironment conditions with unprecedented space and time resolution. It will be driven to isolate CSCs from heterogeneous differentiated and stem cell populations, and force CSCs differentiation, ultimately inducing sensitivity to anticancer treatments. Extensive in vitro and in vivo testing along with biophysical modelling will validate the approach and establish the proof-of-principle within the project life-time, while laying the groundwork for further development of future electrosurgical tools that will be capable CSCs neutralization in tissue. This will not only establish a new line of treatment for brain cancers such as Glioblastoma Multiforme and Medulloblastoma, whose initiation and recurrence were linked to CSCs, and that claim tremendous human and economic tolls, worldwide; it will also push the current boundaries of microbiological analysis by enabling microenvironment characterization/manipulation and real-time ionic channels monitoring without cytotoxic patch-clamping or electron microscopy. By investing in efforts such as SUMCASTEC’s, Europe will stand at the forefront of global biomedical innovation and push through a similar miniaturization trend as the one that propelled mobile communications, yet with much deeper societal impact. All the required competences are gathered within this consortium. The ambitious objectives of the project are planned over 42 months with a requested grant of 3 978 517,5 €.

Keywords: brain tumor,cancer stem cells neutralisation,lab on chip,microfluidics and cmos electronic
PROSME SME- Improving management of innovation processes in SMEs (PROSME-INN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Romania
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-07-01
End date: 2014-12-31
Duration (months): 6.0
Total project cost (EUR): 18000.0
EU funding (EUR): 14400.0
Participants: 2
Project status: CLOSED

PROSME-INN has the objective of delivering consultancy services, as Key Account Manager for the SME Instrument beneficiaries and enhancing innovation management capacity for SMEs in Romania RO3 statistical region. The project involve two Enterprise Europe Network partner from PROSME BISNET consortium which will use various consultancy tools for services delivery.

Keywords: innovation management,key account management,consultancy for smes
Scalable Hybrid Variability for Distributed Evolving Software Systems (HyVar)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Norway,Norway
Call: Tools and Methods for Software Development (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 2793870.0
EU funding (EUR): 2793870.0
Participants: 6
Project status: CLOSED

HyVar proposes a development framework for continuous and individualized evolution of distributed software applications running on remote devices in heterogeneous environments. The framework will combine variability modeling from software product lines with formal methods and software upgrades, and be integrated in existing software development processes. HyVar's objectives are (O1) to develop a Domain Specific Variability Language (DSVL) and tool chain to support software variability for such applications; (O2) to develop a cloud infrastructure that exploits software variability as described in the DSVL to track the software configurations deployed on remote devices and to enable (i) the collection of data from the devices to monitor their behavior; and (ii) secure and efficient customized updates; (O3) to develop a technology for over-the-air updates of distributed applications which enables continuous software evolution after deployment on complex remote devices that incorporate a system of systems; and (O4) to test HyVar's approach as described in the above objectives in an industry-led demonstrator to assess in quantifiable ways its benefits. HyVar goes beyond the state-of-the-art by proposing hybrid variability; i.e., the automatic generation and deployment of software updates combines the variability model describing possible software configurations with sensor data collected from the device. HyVar's scalable cloud infrastructure will elastically support monitoring and customization for numerous application instances. Software analysis will exploit the structure of the variability models. Upgrades will be seamless and sufficiently nonintrusive to enhance the user quality experience, without compromising the robustness, reliability and resilience of the distributed application instances. To maximize impact and innovation, the consortium balances carefully selected academic and industrial partners ensuring both technology pull and push.

Keywords: software engineering,software maintenance,software evolution,software product lines,variability models,distributed software,over the air updates,data intensive systems,internet of things
Advanced Lightweight and Flexible Array with Mechanical Architecture (ALFAMA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling advances in space technology
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,France,France,France,Netherlands,Netherlands
Call: Generic space technologies (H2020-SPACE-2018, 2018)
Start date: 2018-11-01
End date: 2021-10-31
Duration (months): 36.0
Total project cost (EUR): 2998238.75
EU funding (EUR): 2998238.75
Participants: 9
Project status: CLOSED

More and more missions require power supply > 25 kW such as solar electrical propulsion, high throughput satellites. However, the restricted volume between the fairing and the spacecraft sidewall limits the number & the dimension of rigid solar panels during launch. Therefore, the answer for this growing power demand lies neither in stacking more rigid solar arrays, nor by marginal efficiency improvements on III-V multi-junction solar cells, but rather in innovative/disruptive photovoltaic solutions. More solar cells per unit of volume are needed in stowed configuration, and flexible solar arrays are the only answer for this high-power challenge. In this context, ALFAMA project brings answers for the mass, cost & power challenge, with ambitions at each level of the solar array: - The mechanical architecture, with a modular & retractable deployment system - The photovoltaic assembly fabrication process, with printed harness & lamination for easier integration, manufacturing and high voltage protection - The PVA structure, with thin flexible layers for high power/mass & power/volume ratio, adapted to epitaxial lift-off - The solar cells, with the development of highly efficient & lightweight III-V IMM lift-off cells. ALFAMA brings together a team of 8 partners, leaders in their field, from 3 EU-member states, who will join their efforts towards the realization of a disruptive solar array technology (end TRL 4-5), with the following key performances: 1/ Power/mass ratio increased by ≥ 50% with III-V lift-off solar cells 2/ Cost reduction with high throughput assembly process 3/ Power density increased more than 4 times with compact stowed configuration 4/ Relevant roadmaps for space & non-space applications ALFAMA's drastic improvements will enhance the EU space sector competitiveness, enable new missions and build synergies between space and non-space activities.

Keywords: solar cells,epitaxial lift off,inverted metamorphic 3 junction,flexible solar array,printed electronics,lamination,mechanical architecture,deployment system,high power systems
The Fragmentary Constitutions of Aristotle (PolArist)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

One of the greatest minds of antiquity was no doubt Aristotle. He is usually studied or read as a philosopher. However, his entire life, Aristotle was also a researcher, fascinated by history. His most important historical work is his huge collection of Constitutions, which were a gold mine of unique information on the history and organization of the Greek city-states. Only the Athenian Constitution survives almost in its entirety. Of the other constitutions all that remains are "fragments," i.e. citations in extant writers, and the epitome by Heraclides Lembus. There are many editions and studies of the Athenian Constitution, but nothing comparable is found for the other constitutions. Therefore, my project will focus on the fragmentarily preserved constitutions, more specifically the 44 constitutions which were also included by Heraclides. My aim is to define the content and structure of the fragmentary Constitutions, study the link with Aristotle’s political philosophy, explore his reception and the relation to other ancient writers and identify the sources, method, historical value and authorship. For this purpose I will make an edition, translation and commentary of the fragments, which will be published as a book by Brill. This research will fill a major research gap in our knowledge of Aristotle’s lost works and his impact on western civilization. The Constitutions also offer valuable information on the political system and culture of many Greek cities. Ancient Greece is usually considered the ancestor of our modern democracy, but the reality is much more nuanced than we often make it out to be. The Constitutions can help us better understand the ancient world, which may serve as a mirror for modern discussions about justice, power, autonomy and government. LMU will be the perfect host for this project, since it gathers world-class authorities on Aristotle and hosts the Bavarian State Library, which contains one of the best classics collections in the world.

Keywords: aristotle,constitutions,fragments,edition,political philosophy,history and organization of greek city states,greek historiography
Integrating photochemistry in nanoconfined carbon-based porous materials in technological processes (PHOROSOL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Spain,France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-03-01
End date: 2022-02-28
Duration (months): 72.0
Total project cost (EUR): 1994179.62
EU funding (EUR): 1885293.09
Participants: 2
Project status: CLOSED

The aim of this proposal is to exploit the potentialities of confined pore spaces in technological processes related to applied photochemistry for gas sensing, energy conversion and environmental protection. I will focus on new light responsive nanoporous carbons which characteristics can be tailored at two levels (pore void at the nanometric scale and surface functionalization) during the synthesis to modulate their selectivity towards a given molecule (i.e. gas sensing) or efficiency in a given reaction (i.e. energy conversion, environmental protection). The dual nature of the nanoporous carbons with ad-hoc designed pore architectures acting as nanoreactors (confinement) and photoactivity defined by composition (chromophoric groups) offers new perspectives in the fields of light harvesting of applied photochemistry, and shows multitude of fundamental questions that are worth investigating to exploit this concept. Understanding of the confinement effects and the light/solid/molecule interactions is the key for integrating carbon nanostructures in a whole new array of applications. An example would be the design of multifunctional spatially organized photoactive carbons with high electron mobility, multimodal pore systems and chromophoric groups. These systems are expected to show enhanced diffusion and mass transport, with great potential in gas sensing applications where a fast, sensitivity and selective response is needed. I plan to work with functionalized light-responsive polymeric nanoporous carbons (mainly gels, graphene-oxide frameworks). A smart design of hybrid nanostructures introducing other confined photoactive elements will also be studied. The outcome of the proposal is to understand the fundamentals of photochemistry of carbon nanostructures for the implementation of best performing materials in different technological processes related to photochemical energy conversion for H2 and O2 generation, gas sensing and environmental protection.

Keywords: photochemistry,energy conversion,materials chemistry,light harvesting,photoremediation
Beyond solving static datasets: Deep learning from streaming data (KeepOnLearning)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Belgium
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 2499065.0
EU funding (EUR): 2499065.0
Participants: 1
Project status: SIGNED

Data is key for modern AI solutions, especially deep learning. Unfortunately, the data-driven nature of deep learning that makes it so powerful when dealing with complex and high-dimensional data, is also at the core of its main weakness: a model is only as good as the data it builds on. In this project, we want to tackle some strong limitations inherent to the standard machine learning paradigm, which makes restrictive assumptions that are problematic in many real-world (“in the wild”) conditions. By addressing these, we want to make a fundamental step towards more powerful deep learning systems that can learn continuously and know how to adapt as new data becomes available, in the context of computer vision. Traditional deep learning relies on the training data being representative for data encountered during system deployment. This is perfect when working with stationary datasets. Yet in practice, data distributions are often non-stationary, i.e., they change over time. This can have a multitude of reasons – think of social trends, seasonal or geographic variations. This calls for a new generation of deep learning methods, able to adapt to new conditions by continuously updating the models based on new training data becoming available. Learning from non-stationary streaming data is, however, still a major challenge requiring fundamental research. In this project, we build on our earlier expertise in continual learning, to realize this ambitious goal. If successful, this will lead to machine learning systems that keep on learning over time, systematically improving their skills and never getting outdated. It also may lower the threshold for applying machine learning, as it reduces the need for a skilled data scientist carefully preparing the data beforehand. As a practical application, we plan to showcase our work’s feasibility, scalability and flexibility in the context of automatic generation of audio descriptions of videos for the visually impaired.

Keywords: continual learning,computer vision
Value to Linguistic Differences: Misspelled Inscriptions from Ancient Spain (VaLiD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Hungary
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2021-03-17
Duration (months): 24.0
Total project cost (EUR): 146239.2
EU funding (EUR): 146239.2
Participants: 1
Project status: CLOSED

VaLiD aims to reconsider the nature and the significance of deviant spellings and errors in Latin inscriptions in the light of territorial and sociological diversities, by applying modern approaches to the ancient materials. The privileged field of study will be the Roman province Hispania Citerior but comparisons with other territories represent an essential aspect of the investigation. The project is expected to return important information about the spoken Latin of Hispania as well as about the literacy levels of the province, focusing on the social and gender components of the Hispanic society.

Keywords: latin dialectology,computerized dialectology,geolinguistics,roman provinces,roman spain,hispania citerior
Misshaping by Words. Literary Caricature between Texts, Images, and Mental Models (MISWORD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-01
End date: 2019-01-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Neuroscientific research suggests a link between the style of caricature and neurocognitive procedures of perception: the brain perceives reality and makes sense of it by isolating and emphasising patterns. Similarly, by misshaping and exaggerating visual features, caricature provides an enhanced perception of facts and feelings, uncovers hidden aspects of reality, and reveals unconventional knowledge about the world. Insofar as the image of the human figure is a space where a broad range of meanings are inscribed, the definition of caricature requires a wideranging methodological framework, enhancing visual studies with a philosophical and anthropological perspective. As it deforms the body and its social skin, caricature questions the concept itself of subjectivity, as well as hierarchies and balances of power. Moreover, from its early genesis, caricature is connected to anatomical studies and the evolution of scientific knowledge: medical inquiries about feelings and emotions contributed to interface the outer representation of the body with the comprehension of the inner world of human beings. Grouping all these elements, caricature is a complex cultural object, and inherently a hybrid between visual and verbal codes. However, approaches to caricature have neglected its textual dimension: thus the aim of this project is to provide a theoretical definition and a historical overview of literary caricature conceived as a figure of speech in its own right. Drawing on the tradition of studies on the relationships between words and images, the research will trace the presence of caricature in literary texts, providing an anthology of case-studies from different periods of Italian literature, compared with French and English examples. Thus showing how, from the illustrated book to newspapers and digital media, caricature inhabits a cross-media space where historical variables and universals of cognition, cultural schemas and mental models interact with each other.

Keywords: humanities,caricature,italian studies,european literature,words and images,cultural history,history of the body,comic,satire,theory of perception,neurocognitive sciences,media theory
Quantitative analysis of DNA methylation maintenance within chromatin (MaintainMeth)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Austria,United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-04-01
End date: 2023-03-31
Duration (months): 72.0
Total project cost (EUR): 2749962.0
EU funding (EUR): 335492.0
Participants: 2
Project status: SIGNED

Cytosine methylation is a chemical modification that is precisely copied when DNA is replicated. Because methylation can regulate gene expression, accurate reproduction of DNA methylation patterns is essential for plant and animal development and for human health. The enzymes that maintain DNA methylation have to work within chromatin, and particularly to contend with nucleosomes – tight complexes of DNA and histone proteins. How methylation of nucleosomal DNA is maintained remains unknown, and even the simple matter of whether nucleosomes hinder or promote methylation is controversial. My laboratory’s recent work with DDM1 – an ancient protein conserved between plants and animals that can move nucleosomes – and linker histone H1, which binds to nucleosomes and the intervening ‘linker’ DNA, has allowed us to formulate a model wherein movement of nucleosomes by DDM1 dislodges H1 and allows methyltransferases to access the DNA. Furthermore, this work revealed the existence of unknown factors required to maintain DNA methylation. My laboratory also discovered that DNA methylation influences nucleosome placement, thereby demonstrating that the interaction between DNA methylation and nucleosomes is bidirectional. My goal is now to deeply understand the connected processes of maintenance methylation and nucleosome placement. This will be achieved through three interconnected research strands: 1) Elucidation of how DNA methylation is maintained within chromatin. 2) Identification of new DNA methylation maintenance factors. 3) Determination of how DNA methylation influences nucleosomes in vivo. Our ultimate output will be the creation of a mathematical model of DNA methylation maintenance that will incorporate the bidirectional interactions between methylation and nucleosomes. This breakthrough will revolutionize research in the field by permitting the development of precise, quantitative hypotheses about the maintenance and function of DNA methylation within chromatin.