Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The price of success: what is the impact of improving patients’ survival on utilisation of care? (PoS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: CLOSED

Unplanned emergency admissions absorb a large share of the resources allocated to the Health System and are growing at a fast rate in many European countries. The drivers of this growth go beyond demographic factors and have not been properly investigated until recently due to the lack of rich longitudinal datasets following a large population of patients for many years and a gap in the transfer of knowledge between Economics and Public Health disciplines. My ambition is to fill this gap in the knowledge by applying state-of-the-art econometric models to an exceptionally comprehensive and longitudinal dataset on the population of Danish patients, thus offering a unique opportunity to inform new policies on the appropriate tools to manage the growing demand for emergency care and the financial sustainability of the Health System, and policies aiming at reducing hospital readmissions. Access to new data, knowledge and training at the Danish Centre for Health Economics in SDU will allow me to greatly advance and expand my stream of research and will have a remarkable impact on my career development. The proposed research will address the following questions: 1. What is the long-term impact of improving patients' survival on subsequent use and costs of care? 2. To what extent can primary care reduce the use of secondary care following “the survival effect”? 3. To what extent can higher integration of care between acute and post-acute services reduce the use of secondary care following the survival effect? 4. Is the impact of the survival effect different according to patient’s socioeconomic characteristics? I will identify the profile of patients who are more likely to use care after surviving an acute event, and those who are more likely to benefit from primary care and integration of care interventions.

Keywords: costs of care,quality of care,hospital emergency admissions,hospital mortality rates,hospital readmission rates
A new process for the manufacture of methanol from waste glycerol (GreenMethanol)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-02-01
End date: 2016-01-31
Duration (months): 12.0
Total project cost (EUR): 149994.0
EU funding (EUR): 149994.0
Participants: 1
Project status: CLOSED

The idea is to bring to pre-commercial stage a highly effective, economically feasible catalyst for the conversion of glycerol (a waste product from the manufacture of biodiesel) to methanol developed under the ERC Advanced Grant – ‘After the Goldrush’ (ERC-2011-AdG-291319). ‘After the Goldrush’ is aimed at developing cheap alternatives to precious metal catalysts, particularly those containing gold and palladium that can be difficult to commercialise due to their high cost. During our initial studies which focused on finding uses for waste glycerol produced from bio-diesel manufacture. We were exploring the use of glycerol as a starting point for the synthesis of valuable compounds using redox reactions involving oxygen and hydrogen transfer reactions. Biodiesel manufacture takes triglycerides and other fatty materials that can be derived from plant or animal sources and reacts this with methanol typically in the presence of liquid sodium hydroxide. The process produces high quality biodiesel together with glycerol as a waste product. Typically on a mass basis 10 tons of biodiesel produce 1 ton of glycerol as an undesired by-product. This waste glycerol is highly contaminated with residual sodium hydroxide and unconverted fats; it represents a huge environmental problem that keeps a brake on the future expansion of biodiesel production. Hence there has been much research dedicated to finding commercially viable uses for this waste glycerol. We have discovered that this waste glycerol can be converted into methanol in the presence of water and this new reaction is the proposal we wish to bring to a proof of concept demonstration stage.

Keywords: biodiesel,methanol,glycerol,catalysis,heterogeneous catalysis
Towards a ton-scale Ge-76 observatory for neutrinoless double beta decay (GemX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2025-09-30
Duration (months): 84.0
Total project cost (EUR): 3355460.0
EU funding (EUR): 3355460.0
Participants: 1
Project status: SIGNED

The observation that matter dominates over anti-matter in the Universe is one of the most critical open questions in physics. A natural explanation of this asymmetry postulates neutrinos as their own anti-particles, usually referred to as Majorana particles. The only practical way to establish the Majorana character of neutrinos is the experimental search for neutrinoless double-beta decay (NDBD). This decay violates lepton-number conservation and would establish new physics beyond the Standard Model of particle physics. The Germanium eXploration (GemX) project will focus on cutting-edge research towards a ton-scale NDBD decay experiment based on germanium detectors enriched in 76Ge, and thereby sustain a European leadership also in the next-generation worldwide experimental competition. With its superior energy resolution and lowest background, a one-ton 76Ge experiment has potentially the highest sensitivity for discovering NDBD decay amongst the next-generation experiments. A discovery would be groundbreaking in the fields of particle physics, astrophysics and cosmology. The goal of GemX is to develop and evaluate novel HPGe detectors enriched in 76Ge, test their performance in LEGEND-200 and inform the design decisions of the future flagship 1000-kg experiment LEGEND-1000, which the PI leads as elected European spokesperson. GemX will (1) investigate new Ge detector designs with increased mass and improved pulse shape discrimination to enhance background reduction; (2) develop a crystal growth process from germanium material enriched in 76Ge for large high-purity Ge crystals with suitable net-impurity concentrations in Europe; (3) develop the production of large Ge detectors enriched in 76Ge with minimal activation by cosmic radiation and with full control of surface contaminations from alpha contaminations; (4) deploy, test and operate the novel detectors in the TUM underground liquid argon test stand and in LEGEND-200 at the LNGS, Italy.

Keywords: neutrino,astroparticle physics
Revinax platform for 3D Virtual Reality Learning Techniques for Complex Medical Applications (VR4Health)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: France
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-09-01
End date: 2016-11-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Recent studies have shown in Germany, 18,000 people died due to hospital errors. This number was even higher in the United States. Tracing this preventable problem to the source, we found that our surgeons, doctors, and medical students still participate in traditional ineffective means of learning. Students are put through years of lectures while never fully engaging in practice. When the students are finally allowed in the surgery room, it is only to witness and they miss the point of view of the surgeon. In response, Revinax has created VR4Health project that exploits the idea of using interactive virtual reality as a training method. Revinax’s process consists in: 1.Record the surgeries using a state-of-the-art camera rig that enables the surgeon’s point of view, 2.Edition of the video/audio, 3.Transferring the video into a software app compatible for smart devices 4. Additional integrated e-learning options like Observer feature (for interactivity between trainer and students) and pedagogical contents (tests, anatomical atlas, etc) . Studies prove that the introduction of virtual reality into surgical training is superior to conventional training allowing undivided focus, an emotional connection, and adaptation to real life experiences, all in the surgeon’s point of view. The emerging e-learning market is growing rapidly with the growth of the market almost expected to double in the next 5 years. We have developed an innovative solution that will greatly improve surgical training allowing to decrease surgical errors, and the associated burden for EU healthcare systems. At the same time VR4Health will boost the growth of Revinax to get estimated profits of €13.28M by 2016 and achieve a headcount growth of 23new employees. Additionally, we plan to gradually expand VR4Health to other continents and eventually participate in an UNESCO sponsored project to provide better surgical education in African and Asian countries.

Keywords: virtual reality,surgery training,e learning platform
Revolutionary opto-biological methodology for aggressive HER2 cancer (SDS-OmiProbe)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Poland
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-12-01
End date: 2022-12-31
Duration (months): 61.0
Total project cost (EUR): 3985000.0
EU funding (EUR): 3985000.0
Participants: 1
Project status: CLOSED

According to World Health Organization, cancer is one of the leading causes of morbidity and mortality worldwide, with approximately 14 million new cases per year. Breast cancer is the most common cancer among women, and is considered the second most common cancer overall. Each year about 1.7 million new cases are diagnosed worldwide and over 500,000 women die from the disease. Current diagnosis methods of cancers fail to deliver objective results. Diagnosis require extracting tissue samples via invasive and expensive biopsy, followed by laboratory analysis, which are subject to significant levels of discordance. SDS Optic presents a revolutionary opto-biological methodology that allows for instant cellular processes studies including in-vivo cancer diagnosis with single-cell resolution. SDS-OmiProbe detects presence and measures concentration levels of the HER2+ cancer cells in breast tumours. It is a breakthrough device that carries the potential to address the challenges of SoA cancer markers diagnosis and biopsies. In essence, it is a laboratory test at the tip of a probe, but with greater accuracy, efficacy and quantitative results. SDS-OmiProbe may also be used as a companion diagnostic tool for targeted therapy and targeted therapy drugs. There is compelling evidence that our novel SDS-OmiProbe is addressing a rapid growth trend in a high volume market. Based on Transparency Market Research Report the OmiProbe target market of HER2- biomarker tests is projected to be worth $4.6 billion, with 7.5 million HER2 marker tests performed annually worldwide. In order to close the striking gap in the landscape of currently available cancer diagnostic and targeted therapy tools, and to realize the significant global business opportunity the objective of this project is optimization of the SDS-OmiProbe device, followed by realization of independent clinical trials and dissemination of the results.

Keywords: cell studies,cancer,her 2,biopsy,cellular,antibodies
A Computational Framework For Quantitative Modeling of Leaf Development in Arabidopsis and Cardamine (CFQMLD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Understanding how form emerges in living organisms is a fundamental challenge for biology. Progress, however, has been confounded by the complex chain of interactions underlying the organization of macroscopic forms from molecular processes. Consequently, insights into the manner in which individual genes contribute to the development of form have been elusive; even in well-studied model organisms. In this context, leaves provide a striking example of the self-organization of form – displaying remarkable diversity within and between species. Now, exploiting the close relation between simple leafed A. thaliana and compound leafed C. hirsuta, the Tsiantis lab has identified the key genetic factors underlying their distinct leaf shapes. This opens the door to a detailed understanding of the developmental factors sculpting leaf form. Due to the complexity of leaf development, however, a mechanistic understanding of these factors requires computational models, informed by detailed quantitative measurements of growth and gene expression. Such models permit the systematic interrogation of the interactions linking genetic regulation, cell division and tissue growth to final form. This action proposes to develop such a computational framework. When combined with experimental efforts, these models promise to help elucidate the regulation of leaf form and provide essential insights into shape regulation in eukaryotic systems. The proposed research is deeply interdisciplinary, working at the interface of computer science and developmental biology. Falling directly at the intersection of the Tsiantis lab's expertise in studying the molecular determinants of leaf form and my expertise in computational modeling of plant development, it fully exploits our relative strengths. Thus providing an ideal vehicle to facilitate essential training while addressing a fundamental research problem.

Keywords: leaf form development,computational morphodynamics,comparative development,quantitative modeling,arabidopsis thaliana and cardamine hirsuta
A Novel Wine Elaboration Process (Eternum)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Bodegas Langa, with 150 years of expertise in winemaking, brings forward a project which aims at re-designing the wine production process. Æternum is a novel methodology which creates unique wines, defined by the vineyards microbiology, which mature eternally in an innovative container. Albeit being the largest wine producer in the world Europe’s exportation rates are stunningly low. This is due to a surplus of low quality, non-competitive wine. To bring down excess production the European Commission invests billions of euros in programs like the grubbing of vineyards. Yet the problem subsists and recently Europe called for innovation in the wine production sector to enhance the reputation of European wines and regain market share. However, the actual wine market has reached a maturity state, with scarce differentiation among products. This is mainly due to that fact that producing high quality wine is a lengthy and expensive process with variable results. In order to further control the outcome, the process has become somewhat typified, leading to a general similarity among available wines. Through the use of novel biotechnologies, we have created a completely novel methodology for wine production. By analysing the vineyard’s microbiome, we will develop a highly specific and low impact pest control plan. Moreover, it will allow us to select indigenous fermentation yeasts, making our wines unique. The posterior maturation of the wine along with these yeast, will enrich it with nutrients yielded by these organisms. Furthermore, our innovative container design mimics the shape of the maturation deposits. In this way, we allow an eternal maturation to take place within the bottle.

Keywords: novel wine production process,wine,elaboration,nutrition,eternal maturation,maturation in bottle
Scanfly – The payload lidar not for UAS (Scanfly)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Scanfly is a unique innovative remote sensing device that allows 3D lidar mapping, specifically developed for use by drone. It is a product developed entirely by 3D Target s.r.l. that offers to its customers a service of supply of 3D data updated regularly for self-driving vehicles, but also designers, city planners and municipal infrastructure management companies. Infrastructure, especially the road network, keeps Europe running. Roads ensure mobility - in the neighbourhood, municipality, the region or beyond. The quality of road network affects almost everybody in daily life. From a pure economic point of view spending in new or existing roads is an investment in the capital stock of our society. The proposed solution introduces novelty and added value: thanks to its best performance - it allows to fully automatically analyse the actual state of the elements of urban and extra-urban assets - and its ease of use, Scanfly can immediate recognise the variations, compared to the previously noted status, which can lead to critical issues. The development of machine and deep learning algorithms will allow the automatic analysis of a whole series of elements necessary to populate databases from which V2I service providers and the end user (via app, web-portal, SMS alert) will be able to access through SaaS services to improve vehicle-infrastructure integration and road infrastructure-vehicle-user. Scanfly addresses the needs of a large B2B and B2G user base including 91.489 in EU-28 among subjects responsible for the road infrastructures (private/public companies that manage infrastructures or own infrastructures; public property; service provider commissioned by previous users). They need to maintain the infrastructure to offer an objective risk level as low as possible. Thanks to Scanfly they have a fully automatic analysis of the actual conditions of the elements of the urban and extra-urban assets. Scanfly’s Total Addressable Market is 5.5bn EUR in EU-28.

Keywords: transport engineering,intelligent transport systems,automotive engineering,advanced computing,algorithms and complexity,artificial intelligence,intelligent systems,multi agent systems,btt5 unm
MOving block and VIrtual coupling New Generations of RAIL signalling (MOVINGRAIL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Germany,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Analysis for Moving Block and implementation of Virtual Coupling concept (H2020-S2RJU-OC-2018, 2018)
Start date: 2018-12-01
End date: 2020-12-31
Duration (months): 25.0
Total project cost (EUR): 1299135.0
EU funding (EUR): 1298135.0
Participants: 5
Project status: CLOSED

Train-centric signalling systems represent the most promising technology for increasing railway capacity and reducing railway life-cycle costs. These systems include Moving Block signalling which enables trains running at absolute braking distance, and Virtual Coupling that even aims at running at relative braking distance with train sets virtually coupled into a convoy. MOVINGRAIL aims at the further development of train-centric signalling systems by introducing and applying a multidimensional analysis framework to assess train-centric signalling from the operational, technological and business perspectives. This is applied to Moving Block and Virtual Coupling at different levels, highlighting the differences to traditional fixed block signalling. For Moving Block signalling, state-of-the-art formal methods for train operation modelling are used to assess and improve Moving Block Operational and Engineering Rules for safe and efficient train separation. In addition, strategies and methods are developed for testing Moving Block technology, and an extensible simulation architecture is defined for automated testing that minimizes the amount of on-site testing. For Virtual Coupling, formal methods and simulators are applied to assess and recommend radio-based communication architectures, including train-to-train communication. This also includes an evaluation and comparison of the state-of-the-art of automated functions and communication architectures from Automated Vehicle technology, including platooning. The market potential of Virtual Coupling is analyzed by defining scenarios and applying a SWOT analysis for the various railway market segments. Simulation models of railway operations are used in addition to expert opinions of key stakeholders to feed a multi-criteria cost-effectiveness analysis. The research eventually results in an application roadmap and business risk analysis for the implementation of the Virtual Coupling concept to the different markets.

Keywords: moving block,virtual coupling