Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecular Biology of Nascent Chains: Co-translational folding and assembly of proteins in eukaryotes (TransFold)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2023-03-31
Duration (months): 66.0
Total project cost (EUR): 2069000.0
EU funding (EUR): 2069000.0
Participants: 1
Project status: SIGNED

Biological activity of cells depends on timely production of natively folded proteins by powerful translation and folding machineries. At a critical regulatory intersection of translation and folding, ribosomes act as integration hubs coordinating chaperone, enzyme and membrane targeting factor activity, and mRNA coding sequence specifies local changes in translation speed, influencing folding. Final assembly of proteins into oligomeric complexes however, has long been considered posttranslational and dependent on random collision of fully synthesized diffusing subunits. In a shift of paradigm our recent evidence now suggests that in bacteria, assembly initiates co-translationally assisted by chaperones, and gene organization into operons drives co-localized translation of complex subunits that impacts efficiency of assembly. Fundamental differences in eukaryotes such as rarity of operons and differing chaperone constellations imply a widely different folding and assembly biology, which remains largely unexplored. Our development of the selective ribosome profiling (SeRP) method now allows ground-breaking identification and definition of dynamic interactions of nascent chains, at near-residue resolution. Using SeRP with supporting biochemistry and microscopy, we will unravel the nascent chain molecular biology underpinning protein folding and assembly in yeast. Specifically, we will establish (1) basic features and prevalence of co-translational protein assembly, (2) how chaperones guide co-translational protein folding to affect assembly, (3) whether translation of subunit-encoding mRNAs is spatially organized, and if so, how this occurs, and (4) to what extent translation speed variations affect assembly. Subunit interaction profiles complemented by mRNA localization will expose the timing and interplay of protein folding and assembly steps linked to protein synthesis, establishing a detailed conceptually new biology of complex assembly in eukaryotes.

Keywords: molecular chaperones,co translational protein folding,protein folding and assembly
Estimating a DSGE Model with Rare Disasters (DSGE-RD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Israel,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-01
End date: 2020-07-31
Duration (months): 36.0
Total project cost (EUR): 263385.0
EU funding (EUR): 263385.0
Participants: 2
Project status: CLOSED

This project will estimate a DSGE model with rare disasters using data from the Great Recession. Previous studies on rare disasters have been confined mainly to endowment economies. Extensions to production economies (business cycle models) have been limited. In particular, DSGE models with rare disasters have not been estimated before. The main obstacle is computational, as these models are very difficult to solve. In a recent paper with Jesus Fernandez-Villaverde we have shown that the computational problem can be resolved by a new solution method called "Taylor Projection", which is derived in my paper Levintal (2016). This method is able to solve large DSGE models with rare disasters in a few seconds only. This opens up the possibility of estimating rich DSGE models with rare disasters and conducting policy analysis. The project will implement the new "Taylor Projection" method to solve and estimate a DSGE model with rare disasters for the period of the Great Recession. This will require to extend the current solution method to allow for a ZLB constraint on the interest rate and for Markov-switching parameters, as described in the proposal. An estimated model with rare disasters may help to explain the extraordinary dynamics of the Great Recession. We conjecture that the interaction of a big macroeconomic shock (disaster shock) with the ZLB constraint played a significant role in the recession. The question is what kind of a shock generated the recession. Was it a permanent drop in long term growth, as suggested by the "Secular Stagnation" hypothesis of Summers (2014)? or an uncertainty shock that increased the demand for safe assets, in line with the "Safe Assets" view of Caballero and Farhi (2014)? or a combination of both? The proposed project will shed light on these questions by studying the Great Recession through an estimated DSGE model with rare disasters.

Keywords: dsge models,computational macro,nonlinear models
Molecular Design of Polymers for Biomedical Applications (MEDIPOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Thailand,Czechia,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1232800.0
EU funding (EUR): 1232800.0
Participants: 6
Project status: SIGNED

MEDIPOL (“Molecular Design of Polymers for Biomedical Applications”) is an interdisciplinary, international and intersectoral collaborative effort that utilises the mechanism of personnel exchange between partners located in the EU and Asia to address key aspects of problems of huge international socioeconomic importance. Through carefully planned and integrated secondments MEDIPOL will use knowledge transfer to train 29 ESRs and 20 ERs to be future leaders in both academia and industry. The specific major problems that we shall tackle affect vision and mobility, which are becoming increasingly critical issues in healthcare systems across the world, where the growing socio-economic difficulties of ageing populations are evident at both individual and governmental levels. MEDIPOL is designed to identify, design, develop and disseminate understanding of materials and technologies for systems that will aid and augment the healthy ageing of ocular and dermal tissue. Key to achieving this lies in harnessing the understanding of the moist ocular surface and its relevance to compromised dermal tissue. There are clear links between ocular and dermal sites. Importantly, understanding these analogies facilitates the design of contact lenses especially for use as corneal bandages, of ophthalmic dry eye therapies and of successful burn and wound dressings. These issues are international, they affect quality of life and they are of very significant social and economic importance in both developing and developed economies. MEDIPOL is an integrated 4-year program of knowledge transfer and networking between Aston University, UK (Aston), i+Med S. Coop, Spain (i+Med), Technical University of Liberec, Czech republic (TUL), Chiang Mai University, Thailand (CMU), Naresuan University, Thailand (NU) and Mae Fah Luang, Thailand (MFU). The overarching objective of the proposed joint exchange programme is to establish long-term stable research cooperation between all partners.

Keywords: biomaterials,polymers,biomedical devices,ophthalmic delivery,wound dressings
The inhibition synergism of some plant extracts and common inorganic inhibitors to enhance the corrosion control of the embedding steel bars in concrete (NATCON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-11
End date: 2022-01-10
Duration (months): 12.0
Total project cost (EUR): 86466.24
EU funding (EUR): 86466.24
Participants: 1
Project status: CLOSED

Concrete structures are often strengthened by embedding steel ribs which is known as reinforcement in concrete. Prime setback of reinforcement in concrete is corrosion. Corrosion of reinforcements often limits the durability of reinforced concrete structures. In fact, the high alkalinity of concrete creates an environment that protects steel against corrosion. However, the life expectancy of concrete structures is affected by corrosion of steel reinforcements, because of an aggressive attack of chloride ions or as a result of carbonation. Corrosion of reinforcement has huge economic implications as well as social issues including endangering the safety of people who are working in industries. Corrosion inhibitors are among the methods that can be taken into consideration to reduce the steel bar corrosion. Corrosion inhibitors have been reported to control the corrosion of steel reinforcements without significantly changing the concrete properties. The environmental toxicity of the synthesized corrosion inhibitors has resulted in the search for finding green corrosion inhibitors with lower amount of toxic compounds. Among various compounds the corrosion inhibitors extracted from the plant products are inexpensive, readily available and renewable. Most parts of plants such as leaf, fruits peel, etc., are rich of the compounds that give them the capability to be used as corrosion inhibitor for various substrates in different electrolytes. Although some reports can be found in the literature regarding the use of natural corrosion inhibitors in concrete, not so many data are available on taking advantage of the synergism between inorganic inhibitors and organic compounds extracting from plant products. Accordingly, this study aims to examine the synergistic effect of some plant extracts and common inorganic inhibitors to The inhibition synergism of some plant extracts and common inorganic inhibitors to enhance the corrosion control of the embedding steel bars in concrete

Keywords: concrete,steel rebars,corrosion inhibition,plant extract,green inhibitor,inhibition synergism
ADVANCED TECHNOLOGIES FOR HIGH QUALITY, SAFE AND SUSTAINABLE REGIONAL FOOD PRODUCTION (DRIFT-FOOD)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Czechia
Call: ERA Chairs (H2020-WIDESPREAD-2018-2020-6, 2019)
Start date: 2020-10-01
End date: 2026-09-30
Duration (months): 72.0
Total project cost (EUR): 2487625.0
EU funding (EUR): 2487625.0
Participants: 1
Project status: SIGNED

The goal of the project is to create an interdisciplinary Centre of excellence focused on advanced technologies for high quality, safe and sustainable regional food production. The aim of the Faculty of Agrobiology, Food and Natural resources (FAFNR) is to fill the gaps in food production "from field to fork" on the fertile and healthy soil. Contemporary, Faculty research and education activities cover almost the whole chain from agricultural primary production to food safety, but there is a substantial weakness in the chain, that is the absence of research team dealing with advanced food technologies. The second main objective is to enhance scientific excellence in the field of food technology, food processing, and more widely on food quality, safety, and nutrition by promoting scientific cooperation and integration. The third main objective of the project is to improve the accessibility of innovative technologies to regional stakeholders through cooperation with ERA Chair holder and his/her local and international contacts. The project will bring the main research outputs in the field of processing of agricultural products from local agri-food production, and food processing presented to the small producers. The aims will be achieved by attracting ERA Chair Holder with excellent research credentials and leadership competences, thus creating a research team with broad expertise and wide network for collaboration that will greatly improve the culture of research and research performance. ERA Chair holder will be a director of newly established Food Technology Centre and the position will be equal to heads of the faculty departments. In this position, the ERA Chair Holder will be a member of the Dean’s Board that co-decides on issues related to the operation and strategy of the Faculty. ERA Chair holder will analyse current PhD programmes and will advise on possible changes related to better fit to ERA and modern science in the field of food technology.

Keywords: local food,bakery technology,novel food,regional food,craft food,food science,food technology,food analysis,meat processing,dairy processing,food quality,sustainable food production
Gene networks to investigate lateral gene transfer in parasitic protozoa (GENENET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Protozoan pathogens from the kinetoplastid radiation (Leishmania, Trypanosoma) cause major diseases affecting humans, livestock and plants in the developing World and are an emerging problem in the developed world. Despite their importance for human health, these pathogens are still poorly studied with respect to the plasticity of their genomes and its importance for pathogen biology. The increasing availability of complete genomes provides opportunities to gain a better understanding of their genome content, to understand the role of gene flow in providing new pathogenic abilities and to identify how pathogens differ from their free-living relatives and from their hosts. The proposal involves a promising researcher from Paris, France, with a background in biochemistry and computer science moving to a host laboratory in Newcastle, UK, noted for excellent training of young researchers, and for its research on pathogen evolution, to undertake a multidisciplinary investigation, combining phylogenetics and network-based methods to identify how vertical and lateral/horizontal gene flow have affected the genomes and metabolism of these important pathogens. Host training in analysing pathogen genome evolution and large datasets using sophisticated Bayesian methods for statistical inference will synergistically complement the skills of the researcher in network and graph approaches, to achieve these goals. The project will equip the researcher with generally applicable expertise in computational analysis of large data sets from an evolution perspective and in their biological interpretation. It will deliver the first detailed insights into how lateral gene flow has affected the genomes of strategically chosen pathogens of the kinetoplastid radiation, and it will have general implications for understanding how all eukaryotic genomes, including our own, have evolved and continue to evolve.

Keywords: evolution,networks,phylogenetics,lateral gene transfer
Understanding evolutionary abiotic stress-network plasticity as foundation for new biotechnological strategies (StressNetAdapt)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-08-31
Duration (months): 72.0
Total project cost (EUR): 1996750.0
EU funding (EUR): 1437046.26
Participants: 2
Project status: CLOSED

Abiotic stresses, such as drought or salt stress, affect plant growth and threaten the capacity to feed a growing world population. Understanding and altering how plants deal with stress will be critical for society’s adaptation to a changed climate. I propose a novel systems-biology based approach to identify biotechnological targets based on comparison of interaction and signalling networks of evolutionary related species that show differential abiotic stress tolerance. Similar to most crops, Arabidopsis thaliana is an abiotic-stress sensitive glycophyte whereas several close relatives are stress tolerant. This constitutes an opportunity to understand how plant stress-signalling networks are modified by evolutionary processes to adapt to novel environmental conditions. Biological processes are mediated by physically and functionally interacting proteins. Especially stress response networks are rewired when plants adapt to new environmental conditions. I aim to experimentally map the abiotic stress networks of four closely related brassicaceae: A. thaliana, A. lyrata, A. halleri and E. salsugineum. Novel conceptual advances in interactome mapping and a state-of-the art interactome mapping pipeline will be exploited to ensure direct alignability of the resulting reference networks. In addition the dynamic signalling events under drought stress will be analysed. Using a combination of network alignment, graph theoretical and statistical analyses, data integration, and literature-informed criteria a ranked candidate list of stress response regulators will be assembled. These will be genetically and biotechnologically validated. First level candidates will be tested in Arabidopsis thaliana and evaluated with respect to stress tolerance and overall biomass production. The most promising targets will then be transferred to Brassica napus to evaluate the performance in a commercially relevant crop.

Keywords: protein protein interaction network,interactome,binary interactions,yeast 2 hybrid,protein interactions,network,arabidopsis thaliana,eutrema salsugineum
Community Energy for Energy Solidarity (CEES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Belgium,Croatia,France,France,United Kingdom,United Kingdom,United Kingdom,Portugal
Call: Mitigating household energy poverty (H2020-LC-SC3-EE-2020-2, 2020)
Start date: 2021-06-01
End date: 2024-05-31
Duration (months): 36.0
Total project cost (EUR): 1999977.5
EU funding (EUR): 1999977.5
Participants: 11
Project status: SIGNED

Energy poverty is getting more and more poignant around Europe. According to the latest pan-European report by the EU Energy Poverty Observatory, 37.4M people were unable to keep warm in 2018, 33.8M had arrears on their utility bills, and 19% of households reported being uncomfortably hot during summer. Despite this issue being mainly addressed from the public policy perspective through measures that range from alleviation using social tariffs to subsidies to household refurbishment or purchasing energy efficient appliances, civil society plays a very significant and growing role. Communities have found different ways of getting together to fight energy poverty. Solidarity is the cornerstone of all these initiatives which have huge potential for replication. Renewable energy cooperatives (RESCOOPs) are the most democratic and oldest form of energy community: groups of citizens that get together in a democratic manner to achieve energy resilience, independence and sustainable energy generation and use. The CEES project identifies and analyses the most successful cases of community energy initiatives to tackle energy poverty in Europe, validates them academically and empirically, supports the overcoming of regulatory and financial barriers, and then creates a toolkit for EU replication through RESCOOPs network of +3000 energy communities, a formula which has proven very successful in the past. CEES will facilitate the adoption of behavioural and energy efficiency measures in households, create financial and non-financial support schemes to address energy poverty and empower community leaders (and organizations working in adjacent areas such as financial advice, health care or even fire and police services) to identify and deal with energy poverty, establishing quick and responsive networks. We expect to reach more than 19 000 energy poor households and trigger 2M€ of sustainable energy investment with savings of over 7,5 GWh/year.

Keywords: energy poverty,energy communities,solidarity,behaviour transformation,training,awareness,energy efficiency,social sciences,renewable energy,eu energy poverty observatory
Augmented reality aerial navigation for a safer and more effective aviation (AEROGLASS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Hungary
Call: Small business innovation research for Transport (H2020-SMEINST-2-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 1572500.0
EU funding (EUR): 1100750.0
Participants: 1
Project status: CLOSED

Pilot error is the cause of 60-70% of aviation accidents. Current technologies require that pilots mentally convert complex instrument readings and 2D flat panel displays into 3D, 360° reality which increases their mental load and level of stress, a major negative factor in concentration and appropriate decision making. Aero Glass is a technology that contributes to solve this problem: using Head-Mounted Displays (Epson Moverio, Google Glass or similar) it is the first to bring Augmented Reality to pilots providing an unparalleled 3D, 360° experience in the cockpit, regardless of the visibility. EU Edge, a cutting edge software developer company has developed the concept combining its deep knowledge in augmented reality technologies and the personal background of its founder and CTO, Mr. Ákos Maróy, an active pilot himself. In the past two years the idea became a proven business concept and the beta version of the product was also released in July 2014 based on Epson Moverio smart glasses. Currently 200 active testers are using Aero Glass in our Pioneer Beta Program giving valuable feedback from regular use. In the current SME Instrument Phase2 project we aim to enhance the currently limited features of the software framework demonstrate the technology on the recently released smart glasses platforms improve crucial technical preferences based on user feedbacks demonstrate the impact of the technology on the general aviation sector Our targeted primary market is general aviation - all those not considered to be operated by airlines, charter operators or the military. This segment includes 1 million pilots worldwide, more than 80% of them in our two regional target markets, the EU and the USA. Based on the Feasibiltiy Study we conducted in the 3rd quarter of 2014 EU Edge expects to sell more than 9.000 Aero Glass packages (bundled HMD + software) achieving 10 million € annual sales revenue in the fourth year of commercialization.

Keywords: general aviation,aerial navigation,aviation safety,augmented reality,head mounted display