Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Quantitative picture of interactions between climate, hydrological cycle and stratospheric inputs in Antarctica over the last 100 years via the combined use of all water isotopes (COMBINISO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Earth system science
Countries involved: France
Call:  (ERC-2012-StG_20111012, 2012)
Start date: 2013-01-01
End date: 2017-12-31
Duration (months): 60.0
Total project cost (EUR): 1869950.0
EU funding (EUR): 1869950.0
Participants: 1
Project status: CLOSED

Climate change and associated water cycle modifications have a strong impact on polar ice sheets through their influence on the global sea-level. The most promising tool for reconstructing temperature and water cycle evolution in Antarctica is to use water isotopic records in ice cores. Still, interpreting these records is nowadays limited by known biases linked to a too simple description of isotopic fractionations and cloud microphysics. Another key issue in this region is the stratosphere-troposphere flux influencing both the chemistry of ozone and decadal climate change. Data are lacking for constraining such flux even on the recent period (100 years). COMBINISO aims at making use of innovative methods combining measurements of the 5 major water isotopes (H217O, H218O, HTO, HDO, H2O) and global modelling to address the following key points: 1- Provide a strongly improved physical frame for interpretation of water isotopic records in polar regions; 2- Provide a quantitative picture of Antarctica temperature changes and links with the tropospheric water cycle prior to the instrumental period; 3- Quantify recent variability of the stratosphere water vapor input. The proposed method, based on strong experimental – modelling interaction, includes innovative tools such as (1) the intensive use of the recently developed triple isotopic composition of oxygen in water for constraining water isotopic fractionation, hydrological cycle organisation and potentially stratospheric water input, (2) the development of a laser spectroscopy instrument to accurately measure this parameter in water vapour, (3) modelling development including stratospheric tracers (e.g. HTO and 10Be) in addition to water isotopes in Atmospheric General Circulation Models equipped with a detailed description of the stratosphere, (4) a first documentation of climate, hydrological cycle and stratospheric input in Antarctica through combined measurements of isotopes in ice cores for the last 100 years.

Keywords: ice cores,water isotopes,hydrological cycle,isotopic fractionation
Reaching out and linking in: Heath systems and close-to-community services (REACHOUT)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: United Kingdom,Netherlands,Bangladesh,Kenya,Mozambique,Malawi,Ethiopia,Indonesia
Call:  (FP7-HEALTH-2012-INNOVATION-1, 2012)
Start date: 2013-02-01
End date: 2018-01-31
Duration (months): 60.0
Total project cost (EUR): 7276089.27
EU funding (EUR): 5674678.21
Participants: 9
Project status: CLOSED

Countries striving to provide universal health care coverage and achieve the Millennium Development Goals are increasingly implementing close-to-community (CTC) health services. There is a need for health systems to understand the context and conditions in which these services operate in order to realise their potential. Working with some of the most respected and widely quoted close-to-community services we will identify how CTC services can best be delivered and document generic lessons for system development and strengthening. Building on a strong and exciting partnership, we aim to maximize the equity, effectiveness and efficiency of CTC services in rural and urban slum areas of six countries: Indonesia, Bangladesh, Mozambique, Ethiopia, Kenya and Malawi. We will conduct a situation analysis to guide development of research frameworks. This will be adapted and applied to produce a comprehensive inventory of potential constraints for CTC services. This baseline will guide cycles of interventions for service improvement. We will build capacity on three levels: at practitioner level to enable improved service to be delivered; at researcher level to empower the next generation of researchers in health systems; at policy level to enable transfer of research experience into policy, planning and practice. The interventions will be assessed using the framework to find out what works, in which context and why and what can be improved. Our impact on equity, efficiency and effectiveness will be evaluated using a combination of outcome and process indicators and multiple methods. Analyses will include community and policy maker perspectives and elaboration of CTC providers’ voices in health planning. Through conducting a robust inter-country analysis we will build much needed transferable policy and practice recommendations to strengthen CTC services and empower providers, researchers and policy makers.

Keywords: health systems approach close to community providers human resource management monitoring and evaluation capacity building equity effectiveness ethiopia kenya malawi mozambique bangladesh indonesi
Clinical tRials fOr elderly patients with MultiplE Disease (CHROMED)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: United Kingdom,Estonia,Spain,Sweden,Norway,United Kingdom,Italy,Slovenia
Call:  (FP7-HEALTH-2012-INNOVATION-1, 2012)
Start date: 2012-10-01
End date: 2016-03-31
Duration (months): 42.0
Total project cost (EUR): 3456262.6
EU funding (EUR): 2563530.75
Participants: 10
Project status: CLOSED

The objective of CHROMED project is to evaluate the impact of adopting a health and lifestyle status management system to support elderly patients with a combination of chronic diseases involving respiratory and cardiovascular systems. A large scale clinical trial will be implemented to develop and evaluate clinical protocols and organizational models based on the new technologies in order to improve both quality of life and healthcare costs associated with these patients. The CHROMED idea arises from a previously successful research experience in patient monitoring at home. The CHROMED project focuses its investigation on the applicability of an integrated solution for a pathological condition which: a) is very prevalent in ageing patients and b) severely impairs quality of life: COPD with other typical comorbidities such as congestive heart failure and sleep disordered breathing. An international multi-centric randomized control trial will be implemented in five European regions: United Kingdom, Sweden, Estonia, Spain and Slovenia, representing different social and organizational contexts in Europe. In each country, the participating care organizations have existing practices and procedures for age-related disease management. In CHROMED a specific ICT platform in combination with a set of both well established and innovative devices will be used to collect and process useful clinical data at the patient’s home. In particular, for each patient a set of devices will be defined considering the existing co-morbidities.

Keywords: monitoring,health status,large scale,well ageing,self confident,chronic diseases,elderly,co-morbidities
A low cost Mosquito Contamination Device for sustainable malaria mosquito control (MCD)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: United States,Tanzania, United Republic of,Netherlands,Germany,Belgium
Call:  (FP7-HEALTH-2012-INNOVATION-1, 2012)
Start date: 2012-12-01
End date: 2015-11-30
Duration (months): 36.0
Total project cost (EUR): 6576806.0
EU funding (EUR): 5212772.5
Participants: 5
Project status: CLOSED

Our consortium will focus on the integration of four novel control components in a low-tech (no power source, no need for CO2) and cheap mosquito contamination device (MCD) that will a) lure malaria mosquitoes to an attractive point source, b) infect them there with a fungus as a slow-killing agent, and c) expose them to a juvenile hormone analogue with which they will contaminate their breeding sites and kill mosquito larvae. This is unique because it will be the first vector control tool that targets both adult and larval mosquito stages simultaneously with environment-friendly control agents. We foresee the use of MCDs mostly in the outdoor environment where they will lure, infect, and contaminate host-seeking and resting females. Together with the excito-repellent properties of insecticides used for indoor spraying and bednet impregnation, and possibly spatial repellents, MCDs will serve within a push-pull framework. We aim to develop a low-cost MCD that operates uninterrupted and without maintenance for prolonged periods of. MCDs will be highly useful in areas where insecticide-resistance is hampering the effectiveness of current vector control tools and where behavioural adaptation of mosquito populations has shifted towards outdoor resting and biting. Our goal is to have several prototypes of MCDs in an advanced stage of development and ready for industrial production at the end of this 3-year project. By then, extensive (semi-)field testing in Tanzania and various other countries will have been completed. This proposal brings together a unique mix of business-oriented and academic/institutional partners with a broad range of expertises in fungus and mosquito biology, mosquito behaviour, trapping technology, materials sciences and entrepreneurial interests. We will synergise our abilities to make substantial progress to achieve our goal: to add a novel, effective, and economic alternative to the limited vector control toolbox available to combat malaria.

Keywords: malaria,mosquito,device,fungus,attractant,juvenile hormone analogue,integrated vector management,push pull strategy
Regularity theory for area minimizing currents (RAM)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Mathematical foundations
Countries involved: Switzerland
Call:  (ERC-2012-StG_20111012, 2012)
Start date: 2012-09-01
End date: 2017-08-31
Duration (months): 60.0
Total project cost (EUR): 919500.0
EU funding (EUR): 919500.0
Participants: 1
Project status: CLOSED

The Plateau's problem consists in finding the surface of least area spanning a given contour. This question has attracted the attention of many mathematicians in the last two centuries, providing a prototypical problem for several fields of research in mathematics. For hypersurfaces a lot is known about the existence and regularity thanks to the classical works of De Giorgi, Almgren, Fleming, Federer, Simons, Allard, Simon, Schoen and several other authors. In higher codimension a quite powerful existence theory, the ``theory of currents'', was developed by Federer and Fleming in 1960. The success of this theory relies on its homological flavor and indeed it has found several applications to problems in differential geometry. Many geometric objects which are widely studied in the modern literature are naturally area-minimizing currents: two examples among many are special lagrangians and holomorphic subvarieties. However the understanding of the regularity issues is, compared to the case of hypersurfaces, much poorer. Aside from its intrinsic interest, a good regularity theory is likely to provide more insightful geometric applications. A quite striking example is Taubes' proof of the equivalence between the Gromov and Seiberg-Witten invariants. A very complicated and far reaching regularity theory has been developed by Almgren thirty years ago in a monumental work of almost 1000 pages. The first part of this project aims at reaching the same conclusions of Almgren with a more flexible and accessible theory. In the second part I wish to go beyond Almgren's work and attack some of the many open questions which still remain in the field.

Keywords: calculus of variations geometric measure theory regularity theory for elliptic pdes
Dualities in Super-symmetric Gauge Theories, String Theory and Conformal Field Theories (DUALITIESHEPTH)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Fundamental constituents of matter
Countries involved: United Kingdom
Call:  (ERC-2012-StG_20111012, 2012)
Start date: 2012-12-01
End date: 2017-11-30
Duration (months): 60.0
Total project cost (EUR): 1414258.0
EU funding (EUR): 1414258.0
Participants: 1
Project status: CLOSED

The aim of the present proposal is to establish a research team developing and exploiting dualities arising in super-symmetric gauge theories, string theory and conformal field theories. These will also have many applications outside these fields. The overarching aims of the team will be: To develop established dualities into computational tools for physical quantities such as the S-matrix, correlation functions and partition functions. The construction of explicit examples of new dualities. To use such dualities to gain new insights into the mathematical structure of the theories involved. The proposal brings together researchers with different areas of expertise: super-symmetric gauge theories, string theories, conformal field theories, integrable systems and special functions. We divide it into two strands: Strand I. Deals with the AdS/CFT correspondence, scattering amplitudes and correlation functions. The main objectives are to compute scattering amplitudes of planar maximally-super symmetric Yang-Mills to all values of the coupling; extend these computations to the non-planar case; compute efficiently correlation functions in this theory. Strand II. Deals with new and exciting correspondences between four dimensional super-symmetric theories and two dimensional conformal field theories. We aim to find more examples of 4d/2d correspondences and to develop the established ones (and new ones) into efficient computational tools which will be used, for instance, to compute correlation functions in 2d Conformal Toda theories and other CFT's and even physical quantities in theories that do not admit a Lagrangian description. Progress in the first part of this strand will be used to understand the elusive 6d (2,0) theory. Furthermore, we will actively look for common mathematical structures between strands I and II.

Keywords: super-symmetric gauge theories,string theory,conformal field theories,mathematical physics.
Shapeable Magnetoelectronics in Research and Technology (SMART)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Systems and communication engineering
Countries involved: Germany
Call:  (ERC-2012-StG_20111012, 2012)
Start date: 2013-01-01
End date: 2017-12-31
Duration (months): 60.0
Total project cost (EUR): 1499760.0
EU funding (EUR): 1499760.0
Participants: 2
Project status: CLOSED

In our everyday life we are surrounded by sensing devices designed in a way to meet requirements of a certain application, which is determined primarily by their shape and size. What I propose here is to break this old vision in sensor engineering and to develop shapeable magnetoelectronics allowing to reshape sensors upon demand after fabrication. These devices are unique as the same initial sensor can be used for multiple purposes: an elastic magnetic sensor integrated in a fluidic tubing can be applied for therapeutic needs; namely, diagnostics of cancer diseases by examining magnetically tagged living cells. Alternatively the same sensor can be mounted on a curved surface of a stator in a tiny gap between rotor and stator in electrical machines to provide a regulation for the rotor position; these sensors can help to reduce energy consumption of electrical machines. European added value / Sustainability: My group is the first which produced shapeable magnetic sensors and pointed out industrial applications of this technology. Supporting this initiative gives advantage to the EU in development of a unique class of devices with important functionality being not only flexible and fast, but also with the ability to react and respond to a magnetic field. There are no alternatives for this technology; therefore as a long term perspective this project will provide a leading position to the EU in the field of shapeable (magnetic) sensorics. The project is in line with main initiatives of the EU: (i) reduction of energy consumption and (ii) development of novel concepts for disease diagnostics. The European principles of gender diversity management will be obeyed. To accomplish the goals of the project, I need to expand my team by 1 Postdoc and 3 PhDs working on this interdisciplinary project combining physics, engineering, fluidics, and biology. The grant requested is 1499.76 kEUR. The department of research funding (IFW Dresden) will support me to manage the project.

Keywords: stretchable magnetoelectronics,rolled-up magnetic sensor,magnetic cytometry,fluidics,detection of magnetic objects
Physical principles of recognition in the immune system. (RECOGNIZE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Fundamental constituents of matter
Countries involved: France
Call:  (ERC-2012-StG_20111012, 2012)
Start date: 2012-11-01
End date: 2017-10-31
Duration (months): 60.0
Total project cost (EUR): 1267914.0
EU funding (EUR): 1267914.0
Participants: 1
Project status: CLOSED

Receptor proteins on the surfaces of B- and T-cells interact with pathogens, recognize them and initiate an immune response. The diversity and complexity of immune receptors poses a challenge to nonequilibrium many-body physics and our understanding of the physical principles that control the emergent functional properties of biological systems, such as recognition. The diversity of the composition of the immune repertoire emerges as a self-organized process, stimulated by interactions with the environment. The goal of the proposed research is to study the self-organization of the immune repertoire in the face of its pathogenic environment at the molecular and evolutionary level, by using a combination of data analysis and statistical mechanics modeling. Recent experiments have determined the set of B-cell receptors found in a zebrafish and T-cells in humans – data that allows for theoretical analysis and hypotheses rejection that were never possible before. I will theoretically study the problem of recognition from four unique and complementary directions: - guided by statistical signatures in the data I will propose evolutionary models of how selection and mutation in the sequences lead from the genomic precursors to a functional repertoire of receptors, - I will quantify, under simplifying assumptions, the question of the optimal repertoire for recognition in a varying but partially predictable pathogenic environment using maximum likelihood, - analyzing sequence data I will build probabilistic models to characterize the molecular scenarios that generate the repertoire, - I will use information theory and statistical methods to build data-driven models of the molecular nature of recognition based on yeast display experiments. Describing interactions between elements of receptor sequences will be an important step towards a physical understanding of recognition in the immune system, a crucial concept in grasping the onset of allergies and auto-immune diseases.

Keywords: probabilistic models,data-driven models,self-organization,evolutionary models,recognition,optimization in biological systems,stochastic modeling
SOFt Interfaces: control of interfacial layers for biotechnological applications (SOFI)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physical and Analytical Chemical sciences
Countries involved: France,Germany
Call:  (ERC-2012-StG_20111012, 2012)
Start date: 2013-01-01
End date: 2017-12-31
Duration (months): 60.0
Total project cost (EUR): 1498000.0
EU funding (EUR): 1498000.0
Participants: 2
Project status: CLOSED

Microfluidic systems have a tremendous potential for the miniaturization and automation of bio-chemical assays. Cells or genes can be encapsulated in droplets that are manipulated, fused, analysed and sorted at high-throughput. Such systems are extremely powerful for the selection of microorganisms. To go further, I propose now to develop new types of microreactors for biotechnological assays, combining microfluidics and encapsulation. I propose to generalize droplet production to other encapsulation procedures based on SOFt-Interfaces (surfactant-laden interfaces, particle-laden interfaces, soft polymer shells, biofilms...). First, I will characterize the mechanical properties of soft interfaces using interfacial rheology methods and I will develop novel microfluidic methods for the quantitative measurements of the mechanics of microcapsules. Next, I will use microfluidics as a tool to characterize the chemical stability of the microreactors and to induce the release of the contents of the capsules by external forcing. Finally, I propose to use these new types of microreactors in order to control the adhesion of cells inside the microcontainer to develop new high-throughput screening systems for adherent cells. I also envision a novel type of self-sorting microreactor. Based on the recent developments of self-propelled droplets, I will design a system where the droplets containing the object of interest (for example a cell) would sort themselves, by controlling droplet propulsion with an enzymatic reaction. Sorting of microorganisms based on a specific activity is of considerable interest for applications in diagnostics, or selection of organisms for specific tasks. Such self-sorting microreactors would have a huge potential as a new approach to select efficient microorganisms in an automated manner. Such systems can also be seen in the frame of synthetic biology as new microorganisms capable of motion which can be assembled in a bottom-up approach.

Keywords: high-throughput screening,encapsulation,cell-based assay,microreactor,biotechnology,soft matter,microrobot