Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Effect of heterogeneity of cancer cells on collective invasion (HeteroCancerInvasion)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Recent live cell imaging studies have demonstrated that cancer cells invade either as single cell or as cell group retaining cell-cell adhesion. In contrast to the well-documented single cell movement, little is known about collective cancer cell invasion. Given that a single tumour tissue contains various types of cancer cells and the collective movement of cancer cells is sum of the behavior of phenotypically different cells, we hypothesised that intratumour heterogeneity affect collective invasiveness. Careful dissection of the movement of diverse cancer cells is required to study the nature of collective invasion because different behaviour of heterogeneous cancer cells causes complication to understand the movement of whole cancer cell collective. In this study we will utilise and combine the single-cell resolution live cell imaging of 3D collective invasion assay with different types of cancer cell line generated by gene editing and mathematical modelling of invasion assay, which enable us to set up a lot of different possible starting configurations, to test our hypothesis. This project not only advance our current understanding of collective invasion of heterogeneous cancer cell population, but also will be beneficial to design better strategies to limit the invasion and metastasis of cancer.

Keywords: heterogeneity,collective invasion
Understanding the resilience of Amazonian floodplain ecosystems (RESILIENCE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-01
End date: 2019-07-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The riparian forests that flank the major rivers in the Amazon Basin form a highly distinct ecosystem that connects the most biodiverse aquatic and terrestrial environments on the planet. These ‘flood forests’ are inundated for periods of up to six months each year. But although submerged part of the year, flood forests are susceptible to forest fires during the dry season, especially in El Niño (ENSO) drought years. Surprisingly, flood forests poorly regenerate after burning, and after repeated burning can transition to a savanna-like state in which the forest appears unable to regenerate altogether. Our previous field surveys and experiments suggest that seed dispersal limitations may play a fundamental role in understanding the resilience of flood forests to fire perturbations. Fire destroys the seed bank completely. We hypothesise that forest regeneration is arrested by limited seed dispersal as burnt treeless stands affect fish communities and the capacity to retain incoming seeds. Amazonian fishes heavily exploit flood forests during the rainy season. Most flood forest trees produce fruits and seeds during the time of high water, coinciding with the arrival of fishes. Fishes may play an important role as dispersal agents for flood forest trees, as tree seeds have been found in the stomachs of >200 fish species. The reduced input of seeds in burned areas suggests that fishes avoid entering these sites, resulting in a positive feedback that helps to keep these areas in a state of sparse tree cover. In the proposed research, we will assess the ecological barriers that explain arrested regeneration of Amazonian flood forests by evaluating the pathways of seed dispersal and the effects of fire on the composition and abundance of fish communities. Understanding the regeneration of flood forests after fire will become increasingly relevant as extreme ENSO drought events and their associated fires are predicted to become more frequent.

Keywords: floodplain forest,forest fire,ecosystem resilience,forest regeneration,seed dispersal,coupling of terrestrial and aquatic ecosystems,freshwater fishes,amazon rain forest
Seismic Ambient Noise as a proxy to investigate ICE in polar regions (SAN-ICE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Polar regions are some of the least accessible regions on Earth, yet the number of continuously operating seismic stations has increased ten-fold in the last decades. When traveling in presence of ice, the seismic wavefield is reshaped and thus seismology is an ideal powerful tool to extract and monitor key ice-properties. In particular, the seismic ambient noise (SAN) wavefield is recorded continuously in time, having high temporal resolution. Compared to costly satellites and airborne campaigns commonly used to study ice in polar regions, seismology can (a) take records further back in time, (b) fill spatial gaps in satellite and airborne data and (c) fill temporal monitoring gaps. However, little is known about SAN in polar regions and how it can be used to infer ice properties. SAN-ICE will use for the first time a combination of advanced seismic data analysis and full wavefield numerical simulations to (1) characterize seismic wave propagation in presence of ice (both land and sea ice) and (2) infer ice and uppermost crustal properties using SAN. My work will consist of three work packages. First, by using novel and classical seismic methods, I will obtain high resolution maps across the whole Greenland and Antarctica of seismic velocity, density and thickness of ice and crust, completely constrained by seismic data alone. Second, I will perform time-dependent analyses of all the seismic data available up to 40 years ago from Greenland and Antarctica for monitoring ice and crustal structure changes. Third, by modeling the full wavefield and using oceanographic and satellite data, I will investigate the damping effect of sea ice on seismic waves and get new insights on sea ice changes. With this proposed work, I will explore new routes entirely based on seismology and SAN for helping to quantify ice mass changes over time, which in turn, are crucial for predictions of future sea level rise, one of the most devastating potential impacts of climate change.

Keywords: seismology,polar science,seismic ambient noise,ice sheets,sea ice
PODIUM™ - A home device and cloud-based software and algorithm for diabetic foot ulcer monitoring (PODIUM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-01-01
End date: 2019-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

There are 60m adults suffering from diabetes in Europe and 3.8m in UK (5m by 2025). Diabetes has a high mortality rate caused mainly by complications (75,000 deaths p.a., of which 24,000 are premature). One life-threatening complication of diabetes is a diabetic foot ulcer (DFU). Studies revealed a 12% to 25% lifetime risk of developing DFU for diabetics, meaning over 9m Europeans (c.456,000 to 1m in UK) might suffer from DFU in their lifetime. A serious consequence of DFU is lower limb amputation; 85% of the amputations in diabetes sufferers are reported after unsuccessful DFU treatment amounting to 290,000–450,000 amputations/year in Europe, at a cost of €2–2.5bn/year. The PODIUM™ technology is a novel, extremely reliable and highly sensitive solution for the cost-effective diagnosis and monitoring of DFUs through rapid temperature imaging and reliable analysis of thermographs. PODIUM™ will result in increased numbers of prevented DFUs through 10X higher sensitivity than any competitive solutions. A timely response from physicians, facilitated by PODIUM™ could reduce DFU-related amputations and healthcare costs. Thermetrix’s technology will provide a considerable Quality of Life (QoL) improvement for users and enable substantial savings in healthcare even if only a very small percentage would adopt PODIUM™. The global DFU and pressure ulcers market is expected to grow from US$2.8bn in 2015 to US$4.9bn by 2024 (CAGR 6.6%). The objectives of this project are (1) experiment with the introduction of liquid crystalline cholesteric esters instead of infrared-cameras as detection method (dramatically decreasing the cost of the method); (2) validate the higher efficacy, diagnostic value, convenience and cost-effectiveness of PODIUM™ over conventional approaches; and (3) validate the business model based on "unit costs plus cloud subscription" with the aim of generating a ROI of 23:1 based only on European sales only.

Keywords: diabetes,diabetic foot ulcers,wound monitoring
Towards the discovery of efficient CO2 electroreduction catalysts: well-defined RuOx and MoSx nano catalysts (CO2-RR-MODCAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

In future, fuels and basic chemicals may be produced via an electrolytic process that converts CO2, water and electricity derived from renewable energy sources. Such promising, yet underdeveloped technology needs fundamental breakthroughs in the development of efficient electrode catalysts, i.e. electrocatalysts, for CO2 reduction reaction (CO2-RR). In fact, none of the currently known catalysts has adequate efficiency. In this project, I propose to investigate well-defined ruthenium oxide (RuOx) and molybdenum sulphide (MoSx) nano catalysts for the CO2-RR. The goal is to discover new, efficient catalysts on the basis of fundamental insight. In the first phase, model RuOx and MoSx catalysts (nanoparticles, thin films) will be investigated to elucidate the physicochemical parameters that control their performance. In the second phase, synthetic strategies will be applied to enhance the catalyst activity and selectivity; these will be based on the preparation of metal substituted RuOx and on the exploitation of catalyst-support interactions. The proposed investigation is: • Timely, given the relevance attributed by the European Union and by the chemical industry to the research on CO2 re-utilization strategies that involve the integration of renewable energy sources; • Innovative. RuOx and MoSx are promising, yet largely unexplored catalysts for the CO2-RR. The strategies devised to enhance their performance are radically different from what has been proposed so far. • Expected to provide high impact. The structure-activity descriptors identified through this study will open new perspectives for the design of efficient catalysts via controlled synthetic processes. The research methodology is based on the synthesis of well-defined catalysts coupled with a multi-analytical characterization approach. As such, it is ideal to achieve the objectives and it will provide new knowledge for the researcher. The planned collaborations will have great impact for the host group.

Keywords: electrocatalysis,co2 electrocatalytic reduction,solar fuels,methanol,thin film,mass selected nanoparticles,model catalysts,metal oxides,metal sulphides,magnetron sputtering
Visualising transport dynamics of transmembrane pumps (VisTrans)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 2208618.75
EU funding (EUR): 2208618.75
Participants: 1
Project status: SIGNED

The project will investigate multi-component molecular machines that drive substrates across the cell envelope of bacteria. Some of the machines pump antibiotics or toxins, and so contribute to drug resistance and virulence in pathogenic strains. Questions that will be addressed include what the molecular pumps look like, how they are assembled and regulated, how they capture and translocate substrates, and the stereochemical basis for the cooperative switching of substrate-binding states. Molecular pumps that will be studied include tripartite systems driven by ATP hydrolysis, which play a central role in the efflux of macrolide antibiotics and secretion of toxins in Gram-negative bacteria, and those that use secondary transporters energized by electrochemical gradients. We will build upon our earlier observations to prepare a series of intermediates encompassing the key steps in the transport processes, to visualize tertiary and quaternary structural changes, the pathway of substrates in the efflux pumps, and the threading of toxin polypeptides through the constricted channel in the secretion assembly. The pumps and secretion systems cycle through intermediate states, and these will be studied at high resolution by cryoEM and crystallography to understand how the conformational states switch with strong cooperativity and avoid futile cycles that dissipate energy. Our work indicates that the activity of these transporters can be modulated by small peptides and potential co-factors, and we will address how these work. The project will build on our novel approach to engineer the pump assemblies that enables structural analysis at high resolution in isolation and in situ, and will be complemented with mechanistic analyses in vitro and in vivo. The project will deliver a comprehensive, structure-based description of the mechanism of drug efflux and protein translocation by transport machines and their regulation in diverse pathogenic bacteria.

Keywords: membrane proteins,allostery,cooperativity,durg efflux,protein secretion
Creation and Integration of Novel Industrial Value Chains for SMEs in the Raw Materials & Mining Sectors through ICT, Circular Economy, Resource Efficiency & Advanced Manufacturing Innovation Support (MINE.THE.GAP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Innovation actions
Countries involved: Germany,Spain,Spain,Spain,Bulgaria,Finland,Poland,France,Portugal,Portugal
Call: Cluster facilitated projects for new industrial value chains (H2020-INNOSUP-2019-01-two-stage, 2019)
Start date: 2020-09-01
End date: 2023-11-30
Duration (months): 39.0
Total project cost (EUR): 4851150.0
EU funding (EUR): 4851150.0
Participants: 11
Project status: SIGNED

There is a general lack of awareness of the importance of mineral raw materials in today’s society and an (overall) negative view on the concept of mining, strongly related to the use of non-modern, less environmentally-friendly and even outdated methods and technologies. This is particularly relevant for SMEs, which lack the tractor effect of big industries and therefore suffer from innovation deficit, cross-sector fertilisation and disruptive potential. In order to adapt to current trends and technologies, promote industrial modernisation and digitalisation of the sector, and embrace, interact and profit from other emerging industries, the mining & raw materials sectors must undergo a cross-sectoral and cross-fertilisation exercise, with a particular emphasis on SMEs, in order to develop novel industrial value chains that can support the integration of novel materials, techniques and processes. In this respect, industrial clusters and associated entities are therefore the ideal vehicle to promote and accelerate investments in order to develop innovation capacity and product development in SMEs. The overall aim of MINE.THE.GAP is to provide a support platform for the reinforcement of existing value chains and the development of new industrial value chains in the raw materials and mining "target" sectors by means of cross-sectoral and cross-regional innovation and support services in cluster-related SMEs through synergies and interactions with providers and facilitators from the existing and emerging fields of ICT, circular economy, resource efficiency and advanced manufacturing ("provider" sectors"). A well-balanced consortium comprising of 9 Clusters, 1 RTO and 1 Association from 9 regions and 7 European countries representing over 500 SMEs participate in the project to develop a three layered management structure, methodology and strategy including direct financial support to SMEs, additional business support services and access to new investments.

Keywords: mining,raw materials,value chains,smes,cross sectorial,ris3,regions,s3p industry,clusters,emerging industries,advanced manufacturing,circular economy,resource efficiency
Western Strategies in East Asia. The Reconfiguration of US, British and French security policies in the Pacific Century (WESTRAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2020-09-08
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The core question that this project tackles is how the three major Western military powers (the US, Britain and France) have adapted their security policies to the shifting center of strategic gravity of international politics from the Euro-Atlantic area to the Asia-Pacific. In addressing this question, WESTRAT conducts a comparative analysis of their evolving security policies in confronting the main “traditional” and “non-traditional” security challenges in East Asia, i.e. the rise of China, the proliferation of weapons of mass destruction and piracy. In so doing, this project makes three original contributions. (1) Firstly, WESTRAT offers an empirical contribution as the first work to provide a cross-national comparison of the security policies of the three major Western powers (1990-2016) – in their national, bilateral, and multilateral configurations – in what is deemed to be the world’s new center of strategic gravity. It therefore investigates a crucial yet under-explored dimension of contemporary international politics. (2) Secondly, it provides an innovative conceptual framework that sheds light on the emerging networks of national, bilateral and multilateral security arrangements (what we label “networked security postures”) in international politics. It thereby contributes to the debates on the under-theorized relationships between bilateralism and multilateralism as venues for security cooperation. (3) Finally, given the absence of a common European strategy toward the region, this project seeks to enrich the policy discussions in the European Union (EU) and to provide policy recommendations on how to bolster cooperation between the EU, its member states, and the US – and transatlantic relations more generally – in developing a common strategy towards the (re)emergence of East Asia in world politics. Combining concepts and methods derived from international relations, from sociology, and from history, WESTRAT takes an interdisciplinary perspective.

Keywords: international relations,security studies,britain,france,east asia,bilateralism,multilateralism
Topological New Fermions under Laser and New Topological Material Exploring via Machine Learning (TNFL-TMML)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The project of “TNFL-TMML” is a fundamental and scientific project that will be carried out by Dr. Peizhe Tang under the supervision of Prof. Angel Rubio. Dr. Tang is a theoretical physicist with extensive experience and good publication records in the field of topological materials. Currently, he works in Prof. Shou-Cheng Zhang’s group at Stanford University as a post-doctor. Prof. Rubio is one of the leading exporters in fields of ab initio calculations of electron excitations and dynamics in Physics, Chemistry, and Biophysics. Now, he is the managing director of the theory department of MPSD (th-MPSD). This project will aslo involve collaborations with top international experimental groups, who will fabricate and characterise the proposed materials. The proposed project “TNFL-TMML” is focusing on the topological fermions in the bulk states, including Dirac, Weyl and new fermions. These topological fermions can be regarded as new quantum states of matter and attract lots of attentions recently because of their exotic physical properties. Based on the studied objectives, the project of “TNFL-TMML” can be divided into two parts that will keep running in parallel. In Part1, Dr. Tang will study the electronic, optical and dynamic properties of new fermions beyond Dirac and Weyl models systemically via DFT, TDDFT and many body perturbation theory. He expects to discover the new physics and new quantum states of matter which can be verified by the future experiments soon. Part2 is about topological material discovery based on artificial intelligence technologies and self-developed unsupervised ML algorisms. In this part, new methods based on the Big Data of material science will be developed, which will benefit both for academic and industry in the future. Therefore, the success of “TNFL-TMML” will consolidate the leadership of th-MPSD group and create more advanced and effective methodological tools for other scientists in related fields.

Keywords: topological materials,weyl semimetal,dirac semimetal,new fermions beyond dirac and weyl models,first principles calculations,tddft,machine learning,many body perturbation theory