Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Flexible chemical looping combustion for combined heat and power production from biogenic residues with negative emission (Bio-FlexCLC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Sweden,Austria,Germany,Spain,Greece,Netherlands,Poland
Call: Development of near zero-emission biomass heat and/or CHP including carbon capture (HORIZON-CL5-2023-D3-02, 2023)
Start date: 2024-06-01
End date: 2028-05-31
Duration (months): 48.0
Total project cost (EUR): 3948500.0
EU funding (EUR): 3911000.0
Participants: 10
Project status: SIGNED

CHP plants are burdened with significant economic risks when investing in Carbon Capture and Storage (CCS), due to the high cost and energy penalty of CCS. Switching the feedstock from fossil fuels to biomass can significantly reduce the overall CO2 emission; however, it is essential to develop CHP technologies that can utilize low-value biogenic residues and wastes to avoid an increase in the cost of utility. In addition, coupling a bio-CHP plant with CCS results in negative CO2 emissions which is fundamental to many scenarios to reach the net zero emission targets. The Bio-FlexCLC project develops and demonstrates a novel flexible technology for CHP plants at TRL 5 to utilize low-value biogenic residues as feedstock for heat and power production with negative CO2 emissions. Bio-FlexCLC combines the break-through chemical-looping combustion (CLC) technology with conventional circulating fluidized bed (CFB) boilers. The concept is flexible to switch between CLC-CFB modes. Bio-FlexCLC operating in CLC mode has inherent CO2 capture at a low cost and without energy penalty. Bio-FlexCLC utilizes biogenic residues and wastes, improves conversion efficiencies, achieves negative CO2 emissions, reduces SOx and NOx emissions, enhances CO2 capture efficiency at a considerably reduced cost, has flexibility towards load demand fluctuations, and the capacity to switch to CFB combustion if market conditions are not amiable for carbon capture or if there is difficulty in the operation to decreases the risk of implement. Bio-FlexCLC is supported by an expert consortium to ensure the quality of research and appropriate exploitation. The academic partners in the consortium are leading institutions in the areas of CLC and CFB boilers. The industrial partners are technology providers of boilers, chemical looping technologies, as well as gas cleaning and CO2 liquefaction. Bio-FlexCLC is also backed by utility companies in the consortium having CHP plants on biomass and fossil fuel.

Keywords: chemical looping combustion,negative co2 emission
The impact of internal waves on mesophotic cold-water coral mounds in the Central Mediterranean. Past, present and hope for the future (HopeWaves)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Malta,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 161411.52
EU funding (EUR): 161411.52
Participants: 3
Project status: SIGNED

Cold-water-coral (CWC) habitats are sensitive biodiversity hotspots under severe threat from human activities, such as bottom trawling. This is particularly true for the CWC mounds that are recently discovered in mesophotic depths (30-150 m) of Maltese waters in the central Mediterranean. The origin of these CWC mounds is still unknown, and due to the lack of scientific data, these habitats are still not protected. HopeWaves aims to provide an in-depth analysis of the mesophotic CWC mounds in SE Maltese waters, which is essential for planning and enforcing new Marine Protected Areas (MPAs) networks. HopeWaves proposes an interdisciplinary approach (geology, oceanography, and paleoecology) to investigate the factors controlling the development of these structures in recent and past climates, including the role of internal waves and tides (IWs). The specific objectives of this project are: 1) to assess the distribution pattern of recent mesophotic mounds and their associated communities; 2) to determine the characteristics of water masses around the mesophotic mounds to define the possible depth of IWs; and (3) to develop a paleoenvironmental model for fossil mesophotic communities that were formed under a warmer-than-present climate during the Oligocene and the role of IWs in their formation. Specific planned dissemination and communication activities are in line with public and policy-makers engagement. HopeWaves will be carried out at the Department of Geosciences, the University of Malta, which, together with two secondments, will ensure high-level training on seafloor mapping, oceanographic data analysis, grant writing and project management. The fellow will also transfer her knowledge in the field of carbonate sedimentology to the host by contributing to teaching and mentoring activities. This project will increase the fellow chance of having a permanent position in EU universities, marine and oceanic institutes, and centres dealing with coral reef research.

Keywords: cold water corals internal waves mesophotic ecosystems late oligocene central mediterranean malta island
Targeting macropinocytosis in glioblastoma to achieve precision medicine (TargMacropin)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1627988.0
EU funding (EUR): 1627988.0
Participants: 1
Project status: SIGNED

Tumors must survive microenvironmental stresses, such as nutriment deprivation, low levels of oxygen and anticancer treatments. To do so, tumor cells have developed numerous adaptation mechanisms, and we have recently shown that induction of macropinocytosis is associated with tumor cell survival. In our previous work, we determined that the Galectin-3 (Gal-3)/KRAS/alphavbeta3 integrin complex acts as a driver of macropinocytosis, an endocytic process by which tumor cells are able to engulf large amounts of nutrients from the local microenvironment. In glioblastoma (GBM) cells, which do not harbor mutations in KRAS, we interestingly uncovered the same phenomenon of macropinocytosis induction, which was associated with the mesenchymal subset of GBM. My recent work challenged this paradigm of oncogenes, such as oncogenic KRAS, essentiality for macropinocytosis activity in cancer cells. Although the mesenchymal subset is associated with variable expression of several genes, a molecular signature rather than a mutation in a single oncogene defines macropinocytosis. In this context, we also found Gal-3 to be involved in macropinocytosis induction in mesenchymal GBM cells, confirming the central role of Gal-3 in this process. Altogether, my results demonstrate that induction of macropinocytosis is not restricted to tumors bearing mutations in specific oncogenes but can potentially be a universal scavenger process used by tumor cells to survive environmental stress. In this context, the overarching goal of this proposal is to define the molecular mechanisms underlying cancer cell addiction to macropinocytosis, with the ultimate aim to identify targets for the therapeutic exploitation of this mechanism. To achieve this goal, we will combine various functional assays, metabolomic, transcriptomic, and proteomic analyses with a cutting-edge technique of laser capture microdissection together with mass-spectrometry-guided protein identification of the macropinosomes.
Developing tree ring genomics to understand the genetic basis of and predict forest response to climate change (TREE-RING GENOMICS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1498596.0
EU funding (EUR): 1498596.0
Participants: 2
Project status: SIGNED

Economically important and ecologically dominant conifers are succumbing to drought, disease, early-budding and other challenges globally because mature trees are no longer adapted to their current environment under climate change. If we can understand how individual trees respond to different environments, we can match seed sources to an appropriate environment. Existing approaches for understanding adaptive responses to variable environment are effective but agronomic approaches are limited by both long generation times and the genetic diversity they can evaluate and significant variants discovered in environmental GWAS in natural populations are often associated both with adaptation but also demographic structure, confounding inference. We propose a system for quickly estimating adaptive responses for any forest tree. Focusing on annual growth measurements, measured from increment core samples, provides replication of a given genotype across hundreds of experienced year-environments. This allows us to partition growth variation into generalizable environmental responses for years with historical weather or biotic information, using quantitative genomic and ecological approaches to control for correlated responses. We focus on the economically and ecologically important conifer Norway spruce (Picea abies) to 1) develop models and infrastructure to understand the fraction of annual growth that can be attributed to genotype, environment and genotype-by-environment interactions (GxE), 2) map the genetic basis of adaptive response using estimates for GxE as a response in genome-wide association studies (GWAS) and 3) predict genetic responses to novel environments. This approach will enable estimation of the genetic basis of adaptive responses in any population, providing the means to evaluate a tree’s performance in any modelled environment. As environments shift under climate change, this will provide a powerful tool to select parents for healthy, resilient forests.
A META OPERATING SYSTEM FOR BROKERING HYPER-DISTRIBUTED APPLICATIONS ON CLOUD COMPUTING CONTINUUMS (NebulOus)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Greece,Poland,Portugal,Ireland,Germany,Norway
Call: Future European platforms for the Edge: Meta Operating Systems (RIA) (HORIZON-CL4-2021-DATA-01, 2021)
Start date: 2022-09-01
End date: 2025-12-31
Duration (months): 40.0
Total project cost (EUR): 8478106.01
EU funding (EUR): 8478106.0
Participants: 18
Project status: SIGNED

NebulOus will accomplish substantial research contributions in the realms of cloud and fog computing brokerage by introducing advanced methods and tools for enabling secure and optimal application provisioning and reconfiguration over the cloud computing continuum. NebulOus will develop a novel Meta Operating System and platform for enabling transient fog brokerage ecosystems that seamlessly exploit edge and fog nodes, in conjunction with multi-cloud resources, to cope with the requirements posed by low latency applications. The envisaged BRONCO solution includes the following main directions of work: i. Development of appropriate modelling methods and tools for describing the cloud computing continuum, application requirements, and data streams; these methods and tools will be used for assuring the QoS of the provisioned brokered services. ii. Efficient comparison of available offerings, using appropriate multi-criteria decision-making methods that are able to consider all dimensions of consumer requirements. iii. Intelligent applications, workflows and data streams management in the cloud computing continuum. iv. Addressing in a unified manner the security aspects emerging in of transient cloud computing continuums (e.g., access control, secure network overlay etc.). v. Conducting and monitoring smart contracts-based service level agreements.
15th SET-Plan Conference 2021 (SETcon 2021)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Cluster 5 other
Destination: Other Climate, Energy and Mobility destinations
Action type: Coordination and support actions
Countries involved: Slovenia
Call: Support for the SET Plan Conference (HORIZON-CL5-2021-SETPLAN-IBA, 2021)
Start date: 2021-08-01
End date: 2022-01-31
Duration (months): 6.0
Total project cost (EUR): 250000.0
EU funding (EUR): 250000.0
Participants: 1
Project status: CLOSED

The SETcon 2021 proposal aims to successfully organize and hold the 15th edition of the European Strategic Energy Technology Plan Conference and by its means to contribute to the goals of the SET Plan as it is outline on the Horizon Europe, Work Programme 2021-2022, “Climate, Energy and Mobility”). The European Strategic Energy Technology Plan (SET-Plan) was established to accelerate the transformation of the European energy system and to bring new low-carbon energy technologies to market. It identifies actions for research and innovation throughout the whole innovation chain. SET-Plan conferences offers an unique opportunity for decision-makers, researchers and stakeholders to get together and evaluate the progress made towards achieving the SET-Plan’s goals and for informing the general public about the activities and get their support. Under the tittle Research & Innovation to deliver a just and sustainable energy transition present edition will also serve to present Slovenia as an engaged contributor to the SET-Plan priorities. The Conference will take place in Ljubljana on 25-26 November 2021 and will be co-organised by the Republic of Slovenia’s Ministry of Infrastructure as entity responsible of all activities on energy policies during the time of Slovenian Presidency of the Council of the European Union, in coordination with the European Commission DGs Research and Innovation (R&I), Energy (ENER) and the Joint Research Centre (JRC).

Keywords: set plan,energy technology,clean energy,slovenian presidency,policy conference,european strategic energy technology plan,event organization,horizon europe,clean energy transition,green deal,
DYnamic control in hybrid plasmonic NAnopores: road to next generation multiplexed single MOlecule detection (DYNAMO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,Spain,France,Netherlands,Germany,United Kingdom
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 2739590.74
EU funding (EUR): 2628403.2
Participants: 11
Project status: SIGNED

In the quest to develop platforms to decipher the information in biomolecules there is an increasingly demand for techniques that are capable of identifying specific biomolecules at the smallest possible concentration, controlling their capturing and movement at the nanoscale. Nanopore sequencing is a key technology to drive this progress, and solid-state nanopores can be a major technological player. In the field of solid-state nanopores, many challenges remain in particular toward i) design and fabricate nanopore with size comparable to biological pores, ii) dynamic control of single molecule translocation, and iii) multiplexed read-out. Progress toward integrated platforms where both solid-state and biological nanostructures are implemented has been brought by the development of functional nanomaterials and DNA nanotechnology, able to address the importance of nanoscale precision in nanopore platforms with the potential to surpass the performance of biological nanopores. Yet, the integration of biological and synthetic nanomaterials is technically challenging, and their use to fully control and measure single molecule is far from real-world applications. DYNAMO is designed as an innovative research and training network, where we will recruit 10 Researchers to work toward the ambitious goal of developing the next-generation single molecule technologies exploiting hybrid DNA and metallic nanostructures. The network brings together a unique team of 8 world-leading academics and 1 high tech innovative company at the forefront of optical spectroscopy, DNA nanostructures, nanopore technology developments, single molecule detection and control, and biotech real-world applications. DYNAMO will establish an intersectoral training and research programme at the physics/chemistry/biotech interface with partners from 6 EU countries, aimed at creating the next generation of skilled well-connected scientists that will pioneer the ‘single molecule science of tomorrow’.
A computational neuroscience encoding-decoding approach for explaining and comparing artificial and biological networks (Neurosci-ANN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: SIGNED

Recent progress in artificial intelligence (AI) has been mostly due to machine learning and, in particular, deep artificial neural networks (ANNs). Deep learning has an increasing presence in everyday life, including critical applications such as medical diagnosis, transportation, and energy distribution. In response to this, the field of Explainable AI (XAI) has generated much effort in terms of techniques and algorithms to address this problem. However, there is still no consensus on a suite of technology to address these challenges, progress has been extremely limited, and the formal properties of such systems are under-studied. On the other hand, computational neuroscience (CNS) aims to discover the principles behind biological neural networks that enable the brain to support cognition, perception, and action. This project will employ the latest approaches and techniques used in the field of CNS to develop the field of XAI. Specifically, the first major goal will be to employ the methods of representational geometry and neural encoding manifolds (both proven to be effective in revealing meaningful neural relationships in previous studies) to reveal how activations of collections of artificial neurons in hidden layers are associated with the decision-making process of deep networks. Second, the same methodology will be used to reveal novel insights from a variety of existing large-scale biological datasets. Finally, we will compare and contrast the encoding strategies of neural populations found various deep learning architectures with those observed in biological networks. A better understanding of the inner-workings of biological models could directly inform researchers on how to build novel artificial models that are more accurate, robust, and even economical during both training and inference in terms of data, time, and energy consumption.

Keywords: computational neuroscience,artificial intelligence,explainable ai,deep networks,biological neural networks,manifold learning,neural manifolds,neuroai
Cognitive robotic tools for human-centered small-scale multi-robot operations (REGO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: France,Netherlands,Italy,Germany
Call: Pushing the limit of robotics cognition (AI, Data and Robotics Partnership) (RIA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 4585661.25
EU funding (EUR): 4585661.0
Participants: 8
Project status: SIGNED

Robots are still often regarded as large machines with links, gears, and electric motors, autonomously interacting with the surrounding environment. Despite the great research efforts in robotics and human-robot interaction (HRI), the way we design, use, and control robots has not fundamentally changed in the past 20 years. We see in small-scale wireless multi-robot systems and cognitive HRI a revolutionary answer to nowadays robots limitations. Instead of large, tethered machines, that are difficult for the human user to control, REGO proposes an innovative set of AI-powered, modular, microsized swarms of robots. They are wirelessly steered by electromagnetic fields as well as able to react to other external stimuli, and then naturally controlled by humans through intuitive dexterous interfaces and interaction techniques. Taking advantage of AI multi-robot control strategies, these robots can team up and collaborate to fulfill complex tasks in a robust and unprecedented flexible way. By exploiting multisensory interaction techniques and cognitive shared control, the operator will achieve an unparalleled level of seamless interaction and continuous collaboration with the robotic team. According to the application at hand, the robotic team will feature different task-specific characteristics (e.g., biocompatibility for medical procedures, biodenitrification for cleaning water, ability to carry drugs to fight infections) and be dispatched through various delivery systems, including a stimuli-responsive milli-scale wireless robotic carrier developed within the project. To achieve this revolution, REGO will develop magnetic multi-robot motion control systems, autonomous swarm control techniques for micro-sized robots, human-robot haptic-centered interfaces, and cognitive shared-control techniques. REGO enables the next generation of AI-powered interactive small-size multi-robots systems, with increased capabilities to work with each other and their human operators.

Keywords: human robot interaction,multi robot systems,microrobotics,haptics