Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Fluctuating Enzyme: From Catalysis to Vibrational Dynamics (FLUCTENZ)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-08-01
End date: 2026-07-31
Duration (months): 60.0
Total project cost (EUR): 1496875.0
EU funding (EUR): 1496875.0
Participants: 1
Project status: SIGNED

Enzymes spin the wheel of life by catalyzing a myriad of chemical reactions central to the growth, development, and metabolism of all living organisms. Without enzymes, essential processes would progress so slowly that life would virtually grind to a halt, and the quest to determine their inner workings thus continues to attract and fascinate scientists over a broad range of disciplines. Cutting-edge methods now allow one to observe and manipulate individual enzymes in their reaction course. These revealed that chemistry at the single-molecule level is inherently stochastic and, at times, extremely unintuitive. Thermal fluctuations push enzymes to vibrate erratically and force a probabilistic description, but classical approaches are deeply entrenched in determinism, and so is our basic expectation for how things should behave in the world around us. The groundbreaking purpose of this proposal is to bring advanced theoretical methods and mathematical tools to the analysis of stochastic fluctuations of enzymes and proteins at the single-molecule level. These will be based on state-of-the-art approaches in statistical physics and stochastic processes that I will adapt and further advance to need. Equipped with mathematical techniques that have so far been foreign to the field, I expect to rectify fundamental flaws in our understanding, predict the emergence of novel phenomena, and show how single-molecule fluctuations can be extracted from bulk, steady-state, concentrations—despite belief that this is fundamentally impossible. Novel analysis methods that I will apply to tens of thousands of protein structures would complement these efforts and aid in the discovery of unifying principles governing thermal fluctuations of enzymes and proteins. The amalgamation of all these efforts will pave the way to large-scale, multi-tier, characterization of fluctuations which is expected to transform our understanding of enzymes and enzymatic catalysis.

Keywords: single molecule enzymology,noise and fluctuation phenomena,stochastic processes,first passage time processes,queueing theory,gaussian network model,physics of fractal systems
A novel physics-based methodology for the seismic analysis of retaining structures leveraging machine learning techniques (ReStructure 2.0)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: SIGNED

The standard seismic design of retaining structures is based on a century-old theory, that does not account for the actual physical behavior of soil-structure systems. This theory unrealistically assumes that the seismic earth pressure increment is proportional to surface acceleration. Methods based on this theory often lead to conservative design of retaining structures that causes an unsustainable consumption of resources without any benefits on the performance and safety of the construction. Such design approach is against the principles of the European Green Deal that identified the need of cleaner constructions in the Building and Renovation policy area. The main goal of ReStructure 2.0 is to develop a novel physics-based framework based on soil-structure interaction principles, recognizing the relative displacement between wall and retained soil as the driving factor in the seismic response of wall-soil system. The proposed method accounts for soil inhomogeneity and non-linearity, wall flexibility, mass of the wall, and different boundary condition at base and top of the wall. This more adequate design approach can lead to a significant reduction of the resources used during the construction, making the process more sustainable, affordable, and green. This novel approach is based on the combination of computational simulations, experimental and field data, relational databases, and machine learning techniques. Two distinct solutions will be developed: (i) complete frequency-dependent elastodynamic approach, and (ii) simplified single-frequency method. ReStructure 2.0 is tailored around my expertise and profile to give me the opportunity to reach the maturity needed to move forward with my career. This fellowship will allow me to: (i) capitalize on my unique skillset matured in years of international collaborations, (ii) bring back to the EU innovative approaches and methodologies that I developed in the US, and (iii) grow as a researcher, teacher, and mentor.

Keywords: geotechnical earthquake engineering,soil structure interaction
Environmental Diplomacy and Geopolitics (EDGE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Belgium,Slovakia,France
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-03-01
End date: 2019-02-28
Duration (months): 36.0
Total project cost (EUR): 1031250.0
EU funding (EUR): 1031250.0
Participants: 3
Project status: CLOSED

This proposal seeks to increase and reinforce the cooperation that has been initiated between the University of Economics in Bratislava, Sciences Po and the University of Liège in the field of Environmental Diplomacy and Geopolitics. This field of international relations is gaining increasing importance, as environmental issues have become an increasingly important matter in international politics. The three partner universities have all developed a specific field of expertise in relation to the topic of the proposal: The Faculty of International Relations of the University of Economics in Bratislava (EUBA) has developed a wide expertise in the politics of environmental resources, including its security dimension; Sciences Po has recently launched a new research programme entitled Politics of the Earth, which looks at the new geopolitical challenges brought upon by the Anthropocene; The University of Liège (ULG) has specialised into the human impacts of environmental changes, with a focus on migration and health issues. Thus the areas of expertise of the three partners cover a wide range of subjects related to environmental diplomacy and geopolitics: resources, politics and impacts. The key objective of this proposal is to bring these areas of expertise together to create a comprehensive and consistent cluster of research activities. This cluster will allow for a better understanding of the interactions between environmental politics, natural resources and their influence on human populations. In particular, the partnership will seek to achieve the following objectives: 1. Develop joint research activities, events and projects pertaining to environmental diplomacy and geopolitics. 2. Foster cooperation and exchanges of faculty and students between the three partners, as well as with other international, non-EU partners. 3. Reinforce the research and teaching capacities of the partner universities. 4. Develop a common publication strategy

Keywords: environmental security,migration,ressource management,climate diplomacy,climate change,earth governance
Bicyclic hetero peptidimer - a novel molecule format for therapeutic peptides (BiCyHePepDi)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2017-09-30
Duration (months): 18.0
Total project cost (EUR): 131564.7
EU funding (EUR): 131564.7
Participants: 1
Project status: CLOSED

The main objective of the proposed project is the establishment of a generically-applicable new therapeutic molecule format, which will be referred as “bicyclic hetero peptidimer”. We propose linking two bicyclic peptides that bind to the same target but in different locations to generate an antagonist with high affinity and activity. This idea borrows from antibody therapeutics that typically have two arms that can bind to the target, increasing local concentration and improving the overall affinity of the therapeutic. In a second step, we will tether our active bicyclic hetero peptidimer to a known albumin-binding peptide to improve plasma half-life. This has previously been shown to increase the half-life of bicyclic peptides by nearly 50-fold in mice. In the proposed project we will use the new peptide format for the development of picomolar FXII inhibitors. Uncontrolled FXII activity is the cause for the severe disease hereditary angioedema (HEA), where currently no satisfactory therapeutic options are available. This general concept is in no way limited to any particular target, and has the potential to be generally applicable to any peptide-based therapeutics to increase both affinity as well as half-life, two of the major drawbacks to current peptide-based treatment strategies.

Keywords: novel molecule format,therapeutic peptides,fxiia,hereditary angioedema
Forging Ahead: Faking Sagas and Developing Concepts of Cultural Authenticity and National Identity in 17th- and 18th-Century Scandinavia (Forgery)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

The high-stakes game of forgery, from priceless art to counterfeit banknotes, has stimulated public and professional interest for centuries. This project adds to the body of relevant examples, and feeds back into the broader theoretical frameworks, by looking at a number of texts which appeared for the first time in 17th- and 18th-century Scandinavia and were revealed to be forgeries. The most famous (although still relatively unknown) are ‘Hjalmars och Hramers saga', ‘Krembre saga' and ‘Hafgeirs saga Flateyings'. Since their appearance very little research has been done on these works: as literary forgeries they are deemed to have little value in the intellectual and literary history of Scandinavia. This project will prove, on the contrary, that these texts play a central role in the development of literary and philological studies in the region. Moreover, their very existence problematises many of the basic concepts employed by researchers of Scandinavian texts: fiction, history, philology, textual unity, authorial intention and not least national identity. While the overall aim of the project is to bring the importance of these forgeries to light, this will be carried out through three subsidiary aims: 1) Studying the interconnectedness of philological developments with developments in forgery. As forgers develop new techniques, philologists do so too in order to expose fakes, but these dialectical movements are not just opposites, but may also involve a blurring of techniques and aims. 2) Looking into the ways in which international trends have fed into Scandinavian forgery, taking classical and renaissance cases of forgery and forgery exposure as well as enlightenment and romantic causes celebres. 3) Analysing forgery as national fantasy, by using the ideosyncrasies found in forgeries to glimpse the aspirations and interests of both producers and consumers, seen as representative of certain culture-specific desires.

Keywords: forgery authenticity saga philology scandinavia 17th century 18th century
Photo- And Radical induced Reactivity of Atmospheric Oxidants (PhARRAO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2020-07-31
Duration (months): 36.0
Total project cost (EUR): 251857.8
EU funding (EUR): 251857.8
Participants: 2
Project status: CLOSED

The research program will seek to explore the mechanisms and formation/reaction rates of various oxidizing agents pertinent to tropospheric chemistry, using cutting-edge experimental apparatuses and theoretical methods. Firstly, the decay of carbonyl oxides (Criegee intermediates – CIs) will be explored as an important source of OH radicals – fundamental species for the tropospheric oxidizing capability. This will be achieved via a combination of thermal and collision-free experimental measurements. The rate of appearance of OH radicals will be monitored via time-domain measurements (narrow bandwidth IR pump-UV probe). In such approach, the vibrational activation of various alkyl-substituted CIs promoting OH radical production will be explored. Theoretical calculations will predict the OH formation rate from the CIs in correspondence to the barrier for 1,4 hydrogen transfer en route to the products. Temperature and pressure dependent kinetics for the decomposition of the CIs will be determined under atmospheric conditions using cavity-ring down spectroscopy. Finally, the reactivity of various hydroxyalkyl peroxy radicals (HAPs), formed via OH plus alkenes reaction, will be studied. Direct identification of the in situ synthesized HAPs will be carried out in high vacuum via VUV photoionization coupled with mass spectrometry. Temperature and pressure dependent kinetics will be measured for the reaction of the HPAs with various species at atmospheric conditions via near-IR cavity-enhanced absorption spectroscopy. The effect of water complexation on the reaction rates will be explored. All experimental measurements will be complemented by high level theoretical methods and robust atmospheric modelling for extrapolation of the lab results to the atmospheric context.

Keywords: atmospheric chemistry,reaction kinetics and dynamics,molecular dynamics,dissociation,uv and ir spectroscopy,atmospheric reactive intermediates,oxidative chemistry
COmpound COatings NUrturing applications in Tissue Engineering (COCONUTE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-12-27
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

The deposition of particle-laden coatings is key to a number of modern technologies, ranging from semiconductor electronics to bioengineering. In the thriving field of regenerative medicine, deposition processes to manufacture artificial skin in vitro turn out to be particularly challenging. Because skin is composed of several layers with specific cell distributions, space-resolved deposition of cells has to be achieved to obtain viable tissues. However, the delicate nature of living cells and biomaterials strongly limits the number of available techniques, thereby hindering further advances in the field. In this context, COCONUTE emerges as a timely and essential initiative to adapt a well-known technique, dip-coating, to meet the challenges posed by current skin manufacturing technologies. I will investigate, using theoretical and experimental tools, key unknown aspects of the physics of dip-coating in the presence of two liquids, which may have particles in suspension. Gaining further understanding of the physics, I will be able to create compound coatings exhibiting well-controlled arrangements of particles. These particles will have physical properties similar to skin cells to guarantee the applicability of the results to tissue-on-a-chip setups. Not only the time to implement this project is now: the group and supervisors with whom I will carry out my research make a perfect ecosystem for me to turn the project into a success. Being a Soft Matter physicist by training, I will work in a group where fluid mechanicians collaborate routinely with experts in tissue engineering. Thus, the inherent multidisciplinary of the project will allow me to get training in the above-mentioned areas, while also sharing my expertise with the host group. This project will reinforce my chances of becoming an independent researcher in the fields of Soft Matter and Fluid Mechanics, with the focus on state-of-the-art bioengineering applications.
Increase Friendly Integration of Reliable PV plants considering different market segments (TRUST-PV)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Germany,Germany,Italy,Italy,Italy,Italy,Cyprus,Belgium,Belgium,Greece,Lithuania,France,France,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Increase performance and reliability of photovoltaic plants (H2020-LC-SC3-2020-RES-IA-CSA, 2020)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 12878127.91
EU funding (EUR): 9969043.629999999
Participants: 23
Project status: SIGNED

TRUST-PV will demonstrate increase in performance and reliability of PV components (e.g. module O&M friendly design, inverter enabled O&M solutions, aftermarket coatings, extended testing beyond standard) and PV systems (e.g. more accurate yield models and assessment, data-driven mitigation measures from monitoring and advanced field inspection, reliability of novel system concepts such as floating PV) in large portfolios of distributed and/or utility scale PV. The TRUST-PV results will be tested and demonstrated from fab to field and all data gathered along the value chain will flow into a decision support system platform with enhanced decision-making using AI. The innovation at component level in TRUST-PV will be driven by the needs of stakeholders operating in a later stage of a PV project, i.e. Asset managers, EPC and O&M operators. TRUST-PV PV modules will thus become O&M friendly and inverter will enable rapid and cost-effective field inspection. The innovation at system level will fully exploit the digitalisation of the PV sector by linking 3D design with BIM concepts, developing more accurate models for yield assessments, and closing the gap between performance and failure detection through monitoring and field inspection. The innovation at the point of connection is based on the deployment of tailored strategies for the residential sector (better observability of performance with cost-effective monitoring solution, use of storage to enable renewable energy communities) and the utility sector (e.g. combination of advanced forecasting with storage and regulation through power plant controllers) with the final aim of improving the hosting capacity and increase stability. Finally, in TRUST-PV we envision a path of circular economy which enhances disposed components/material recovery for further use in the industry, to support progressive steps of plant repowering, aimed at increasing their production and lifetime without requiring additional land.

Keywords: data driven mitigation measures,digital twin,decision support systems,oandm friendly solutions,sustainable backsheets,grid integration,hosting capacity
A Pan-European Solid-State NMR Infrastructure for Chemistry-Enabling Access (PANACEA)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Italy,Israel,Germany,Spain,Switzerland,Sweden,France,United States,Netherlands,Denmark,United Kingdom,Portugal
Call: Integrating Activities for Starting Communities (H2020-INFRAIA-2020-1, 2020)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 4998890.75
EU funding (EUR): 4998890.75
Participants: 12
Project status: SIGNED

The objective of this project is to establish an integrated Infrastructure that will cater to a starting community of multi-disciplinary chemistry users in need of cutting-edge instrumentation and experimental expertise in solid-state nuclear magnetic resonance (NMR). At the heart of the European economy the wider Chemical Industry is one of the largest manufacturing sectors. Development of modern chemistry relies on the capacity for atomic level investigation of increasingly complex solid substrates in frontier research areas crossing disciplines from catalysis and energy materials through polymers to pharmaceutical formulations and medical implants. Among the range of physical and analytical techniques used for atomic level characterisation, breakthroughs have been made since the beginning of the century in the development and use of solid-state NMR spectroscopy, enabling the characterisation of structure and dynamics, at the atomic-level. This project aims at advancing knowledge and fostering innovation by providing the European chemistry community with effective and convenient access to the best research infrastructures in solid-state NMR available worldwide. For this, we aim to bring together and integrate on the European scale seven national infrastructures across Europe and to incorporate one infrastructure in the United States, and open them to all European researchers, from both academia and industry, ensuring their optimal use and joint development. Our ambitious and far-reaching aims will be broadly achieved by a close synergy between networking activities, provision of transnational access, and joint research activities, additionally involving two industrial technology partners and two of Europe’s leading research groups, so as to improve the quality and quantity of the services provided by the infrastructures, and facilitate the use of modern solid-state NMR by non-expert users, widening the opportunities for novel application areas in chemistry.

Keywords: solid state nmr nuclear magnetic resonance spectroscopy,high magnetic fields,atomic level characterisation,chemistry