Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Social Understandings and Representations of Deafness In Theory and Education through Cinema (SURDITE CINEMA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

Deafness raises profound questions about language acquisition, learning, and thinking including mediation of experiences of the world, self and others and socio-cultural identity and belonging. France has an important place in the history of deaf education. In 1791, two years after the Revolution and as a result of the rights of deaf people being recognized in the constitution, France became the first country to have a national, government-funded school for deaf children, who were taught using sign language. Despite this positive history, there has been little commerce between France and the UK on the subjects of deafness and disability. The originality of this project lies in using cinema to bring together and analyze social, theoretical and educational perspectives on deafness from Francophone and Anglophone spheres. The purpose of this work is to transform social understandings of deafness in the public domain; to construct a dispassionate theoretical and empirical framework for researchers and practitioners working in the fields of deaf studies, deaf education and disability studies; and, to critique and influence national and EU discourses and policies on deafness and disability.

Keywords: cinema,deaf education,deaf studies,disability studies,philosophy,ethnography,cultural studies,modern languages and cultures
Worker participation and job preservation in recessionary conditions (WPART2013)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-04-20
End date: 2017-04-19
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

The proposed research will be conducted by Dr. Gabriel Burdín (the applicant) who obtained his PhD at the University of Siena (Italy) while developing a successful early research career focused on the economics of worker-managed firms. He will be hosted by the centre for Economics Research on Governance and Organization (ERGO) at Leeds University Business School (UK). The scientist in charge is Prof. Virginie Pérotin, a leading international expert on the economics of employee participation. The main objective of the fellowship is to advance the applicant’s career to a level of international leadership by broadening his field of expertise and involving him in an active network of preeminent European and US researchers. The applicant will gain an extensive and multidisciplinary knowledge of worker involvement in general and perform high-quality econometric analysis using the best available sources of microdata in Europe. The fellow will also be trained in complementary skills such as academic leadership and project management. The research will examine whether greater employee involvement in decisions at the enterprise level is associated with more job preservation under recessionary conditions in Europe. It addresses a major current concern of European policy-makers, social partners and citizens that has not been investigated from this angle. Planned for 24 months, the research will provide rigorous statistical evidence on the employment effects of forms of employee involvement that have been actively supported by the European Union but vary widely both across and within Member States.

Keywords: worker participation,employee involvement,employment adjustment,impact evaluation
Time-Resolved Ultrafast Electron Visualization of Evanescent Waves (TRUEVIEW)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-05-01
End date: 2016-04-30
Duration (months): 24.0
Total project cost (EUR): 199317.6
EU funding (EUR): 199317.6
Participants: 1
Project status: CLOSED

Due to the promising potential of evanescent optical waves and surface plasmon polaritons to successfully merge current photonic and electronic technology on the nanoscale, they are generally envisioned as the information carriers of the future. This, however, requires the advanced miniaturization of integrated optical circuitry, which demands great effort not only in fabrication and design, but even more so in the development of accurate control and, above all, a deepest scientific understanding of sub-wavelength-confined light. At present, the thorough understanding of the nanoscale behaviour of evanescent fields and the details of the underlying light-matter interactions are missing, but key elements in modern optoelectronics research. TRUEViEW aims to provide the currently missing fundamental knowledge, by implementing innovative electron imaging techniques as the ultimate tools to directly visualize and characterize photonic and plasmonic nanostructures in both space and time with nanometer and femtosecond resolution. The project takes a bottom-up approach throughout, yielding a systematic and consistent route towards unravelling the working principles of nanoscale-confined optical waves and gaining practical expertise on the manipulation of light in optoelectronic nanostructures. At the same time, the project will pioneer and establish the field of ultrafast electron microscopy in the European research community, as well as newly introducing the novel technique of in-situ Photon-Induced Near-field Electron Microscopy. On the whole, TRUEViEW will lay the groundwork for a myriad of future optoelectronic applications, which include - among many others - sub-wavelength optics, light generation and data storage, nanolithography, quantum computing, quantum cryptography, biophysical spectroscopy and nanosensing. As such, the project will have a strong impact not only all across the scientific board, but also in the European commercial and technological industry.

Keywords: ultrafast electron microscopy,utem,photon-induced near-field electron microscopy,pinem,near-field imaging,sub-wavelength light confinement,nanophotonics,nanoplasmonics,in-situ imaging
Topologically Confined Chemical Reactions Performed Within Substrate-Supported Porous Molecular Architectures (TOPCHEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

The TOPCHEM project investigates an innovative approach to the on-surface synthesis of molecular products by performing chemical reactions within geometrically well-defined 2D regions on a substrate. The size and shape of these regions is governed by the dimensions of a porous molecular template adsorbed on the surface, formed by the self-assembly of hydrogen-bonded or covalently linked molecular architectures. The ‘topochemical’ reactions carried out within these pores may be driven along a specific reactions pathway towards a desired chemical product by utilising the size- and shape-confinement offered by the molecular template. This novel methodology for the control of chemical reactions by defining the number and geometric arrangement of reactant species within a pore has the potential to facilitate multi-component reactions, allowing an alternative route for the synthesis of complex molecules. Scanning probe techniques (Scanning Tunnelling Microscopy (STM) and non-contact Atomic Force Microscopy (nc-AFM)) will be used as the primary tools for characterising the self-assembled molecular templates, as well as the reactant and product molecules. The sub-molecular resolution offered by nc-AFM will enable the identification of the structure of the product molecules, with characterisation on the level of single chemical bonds. Additional chemical information about the molecular systems will be obtained using a combination of photoelectron spectroscopy (PES) and secondary ion mass spectrometry (SIMS).

Keywords: scanning probe microscopy,non-contact atomic force micrsocopy,scanning tunnelling microscopy,heterogeneous catalysis,on-surface synthesis,topochemistry,supramolecular self-assembly.
Protein Synthesis Control by Means of Formal Models (FORMALBIO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-10-01
End date: 2016-10-15
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

Many biological systems at cellular level consist of a high number of elements interacting in complex patterns. These systems often exhibit emergent behaviours that cannot be detected by reductionist approaches. Systems biology is the interdisciplinary methodology aiming at understanding the dynamics of life by determining how the elements of a biological system interact to form functional networks. This research proposal intends to make to advance the state-of-the-art in systems biology by making systematic use of formal models, and more precisely of the Petri nets formalism. The research will focus on the network of interactions involved in the protein synthesis in Saccharomyces cerevisiae, a species of yeast. The overall goal of the proposal is to optimize the recombinant protein synthesis in this organism. This goal is to be achieved by means of three primary objectives: 1) to formally model the recombinant protein synthesis mechanism; 2) to analyse the obtained model by using formal methods; 3) to control the system behaviour to maximize the recombinant protein synthesis. The Petri net to be designed will model the different events taking place in the protein synthesis mechanism: transcription, translation, modification, transportation, degradation and secretion. The analysis of the Petri net will consider structural and dynamical properties, and special attention will be paid to the computation of throughput bounds and bottleneck identification. As bottlenecks constrain the throughput of the whole system, any control action aiming at maximizing the protein synthesis will be performed on them. Overall, this proposal intends to improve our understanding of the cellular mechanism regulating protein synthesis by providing mathematical modelling and analysis tools. This understanding will eventually enable us to control and optimize the synthesis of recombinant proteins, which are broadly used for vaccines, diagnostic tools and therapeutic purposes.

Keywords: systems biology,formal models,petri nets,protein synthesis,dynamical systems analysis and control,throughput bounds,bottleneck identification,continuous and hybrid petri nets.
The role of boron in the crystallization and surface properties of CaCO3 at the nanoscale (NANOCARB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-01-01
End date: 2017-04-11
Duration (months): 24.0
Total project cost (EUR): 308587.8
EU funding (EUR): 308587.8
Participants: 1
Project status: CLOSED

Boron is important in industry and nature. It is used in oil extraction, detergents, superconductors and agricultural chemicals. At neutral to slightly basic pH, where CaCO3 forms, B exists as boric acid and borate. These are present in all sea water so marine organisms automatically incorporate B into their shells. Strangely, nearly nothing is known about the extent of uptake or its effects. In many areas of the Mediterranean Sea and continental Europe, B is a contaminant, risking environmental damage and challenging drinking water supplies. Because so little is known about its behaviour, toxic concentrations are difficult to remove. The goal of NanoCArB is to add to the thermodynamic and kinetic databases for the B-H2O-CO2-CaCO3 system, to provide deeper understanding about the interaction of B with calcium carbonate mineral surfaces and to provide a solid base for interpreting boron isotope fractionation. NanoCArB will use a multidisciplinary approach by combining several state of the art nanotechniques including spectroscopy, microscopy and synchrotron radiation based methods for in situ, real time studies to answer three main questions: How does borate affect the growth rate and growth mechanisms of calcite? What is the effect of borate on CaCO3 surface properties (i.e. adsorbed species, surface tension, inhibition) of calcite? How do the various mechanisms of crystallisation affect surface attachment, incorporation and isotope fractionation in calcite and aragonite. The results will contribute significantly in a number of fields, such as improving drinking water and waste treatment, scale inhibition, oil extraction, and to advance understanding of processes that occur at the global scale, such as ocean acidification and climate change. In parallel, NanoCArB will provide me with the opportunity to direct a research project, enhancing my research management skills, moving me along the path to independence as a scientist.

Keywords: boron,borate,calcite,aragonite,carbonate,scaling,clean water,oil extraction,ocean acidification,surface science,nanomaterials,synchrotron,isotopic fractionation
New Organocatalytic Malononitrile Michael Addition Methodology for the Enantioselective Synthesis of Calyciphylline K (CATSYNCAL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-03-04
End date: 2016-03-03
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Calyciphylline K is a Daphnezomine L-type natural product with promising anticancer activity. We propose to complete the total synthesis of Calyciphylline K and several closely-related Daphnezomine L alkaloids by developing a novel asymmetric organocatalytic Malononitrile Michael Addition methodology to facilitate their preparation in a short sequence of around 12 synthetic steps. The anticancer activity of Calyciphylline K and other analogues prepared during this study will then be evaluated using Alamar Blue cell viability assays, followed by further study in collaboration with the Structural Genomics Consortium (SGC), where high-throughput kinase screening assays are available to further understand their pharmacological mode of action. This project will provide significant advances in the field of organocatalysis (new methodology for asymmetric synthesis), natural product synthesis (first preparation of the Daphnezomine L alkaloids) and anticancer medicinal chemistry and pharmacology (exploration and study of biological activities).

Keywords: natural product synthesis,organic synthesis,organocatalysis,methodology,catalysis
Trojan-Lipid-Sensor (TROJAN-LIPID-SENSOR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-09-16
End date: 2017-09-15
Duration (months): 36.0
Total project cost (EUR): 359081.9
EU funding (EUR): 359081.9
Participants: 1
Project status: CLOSED

Modulation of leukocyte adhesiveness is critical to leukocyte function during the immune response. In order to extravasate from the blood stream, leukocyte rolling must be followed by integrin-mediated rapid arrest. Intergins play a crucial role on chemokine-induced arrest of leukocytes on blood vessels. Signaling events mediating adhesion are extensively studied. Increasing evidence underlays the essential role of lipid second messenger as important fine regulators of signaling cascade leading to integrin affinity modulation. To date, no technology has ever been developed to monitor intracellular production and localization of specific lipids in the context of leukocyte recruitment. Imaging of small molecules in real time in living cells is usually accomplished with genetically encoded sensors, which are typically fluorescent proteins flanking a ligand-binding domain. However, sensor development is difficult since proteins undergoing conformational changes upon binding a desired target molecule are minimally available. In this scenario, my project aims to produce sensors for fluorescence imaging of small molecules using RNA. These RNA-based sensors comprise a ligand-binding RNA aptamer and Spinach, an aptamer that binds and switches on the fluorescence of a small- molecule fluorophore allowing imaging of the dynamic changes and cell-to-cell variation in the intracellular levels of phosphatidic acid (PA) and phosphatidil-inositol-4,5-biphospate (PIP4,5P2). This tool could be the first of this kind and could be useful to study many aspects of signaling cascade events, not only for leukocyte recruitments. By using lipid Nano-Biosensor I could be able to make FRET and FRAP studies in order to obtain in vivo qualitative and quantitative data allowing topological and dynamic reconstruction of signaling networks. Moreover lipid Nano-Biosensors could be developed as innovative new markers for cell sorting in FACS and in ImageStream Technology.

Keywords: nanovector,sensor,rna,tat,cell penetratin peptides,trojan peptides,pips,pip4
Biology of UnderGround Symbioses (BUGS): studies of a subterranean ant-aphid-microbe cooperative network (BUGS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2015-01-01
End date: 2018-06-24
Duration (months): 36.0
Total project cost (EUR): 270312.9
EU funding (EUR): 270312.9
Participants: 1
Project status: CLOSED

Mutualism, cooperative interaction between different species, is widespread in nature. Despite its ubiquity and recognised importance for ecological communities, how mutualism evolves and persists remain major unresolved questions in evolutionary biology. The reason for this is that mutualistic interactions can often be exploited by parasites, and high degrees of species interdependence can increase extinction risk. Applying established network theory to interpret biological details of mutualistic interaction networks has great potential to reveal crucial system properties such as enhanced network resilience through species interdependence. I propose an interdisciplinary study combining network theory with detailed empirical analyses of a so far uncharacterised mutualistic network of subterranean ants, aphids and microbes. The ants protect aphids from predators, and in turn harvest honeydew, processed plant sap excreted by the aphids. In addition, symbiotic gut bacteria in both ants and aphids synthesise essential amino acids and assimilate nitrogen. These bacteria are crucial for upgrading the sugar rich but otherwise nutritionally poor plant sap and honeydew. My project will improve our understanding of mutualisms by unravelling the metabolic and behavioural mechanisms underlying species interdependence in this specialised symbiotic network. To this end, I will (i) assess covariance between bacterial communities of associated ants and aphids, (ii) determine the functional roles of bacterial communities in honeydew composition, and (iii) assess ant behavioural specificity in choice of aphid partners. I will then (iv) further interpret my findings in a broader context by applying network theory to this focal network and other comparable mutualistic networks, thereby adding to our general understanding of the evolution and stability of mutualism.

Keywords: ants,aphids,bacteria,cooperation,ecology,evolution,metagenome,microbiome,mutualism,network theory,partner choice,species interdependence,stability,symbiosis,systems evolution
GLIMPSE: Understanding the dark universe through 3D weak lensing reconstructions (GLIMPSE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-03-01
End date: 2017-02-28
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Weak gravitational lensing has emerged as a powerful tool to probe the distribution and nature of the dark components of our Universe, and thus to better constrain our cosmological model. For this reason, several large projects such as the Dark Energy Survey and Euclid have been commissioned to study this effect. Arising from the deflection of light due to the gravitational potential of structures in the Universe, it manifests as a small, correlated elliptical distortion -- a shear -- in galaxy images. Lensing is sensitive only to the presence of matter, and not to the nature of that matter (luminous, dark, baryonic, etc.), and thus provides an ideal and unbiased probe of the structure of the cosmic web. This proposal will address the problem of mapping the dark matter distribution in three dimensions using measurements of weak gravitational lensing. This is a very complex, ill-posed problem with numerous sources of noise and signal contamination. A focus of my postdoctoral work has been in developing a multidisciplinary approach to this problem, marking a dramatic shift from earlier methods. My new algorithm -- GLIMPSE -- demonstrates an impressive improvement in the fidelity of the maps generated, thereby for the first time opening up allowing 3D mapping techniques to directly constrain the cosmological model. With this in mind, the specific aims of this proposal are to further develop the GLIMPSE algorithm to ready the software for application to survey data, and to more fully develop the applicable theory and statistical tools to allow the outputs of GLIMPSE to be used to directly constrain our cosmological model. This development will establish GLIMPSE at the forefront of the field, and will significantly further the goals of large targeted weak lensing surveys. This is essential to a better understanding of the nature and behaviour of the dark components of the Universe.

Keywords: gravitational lensing,signal processing,sparsity,density mapping,compressed sensing,simulations,large surveys,statistical methods,cosmology