Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Greenly synthesized nanomaterials for phosphorus recovering and recycling in agricultural catchment (GreenP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: CLOSED

Excessive phosphorus (P) use in intensive agricultural food production is threatening the one-way flow of P from mineral reserves to fields and subsequently into waterways. Only 30% of the P supplied to soils in Europe is utilized by plants, with the remainder accumulating in the soil and being lost through runoff and subsurface drainage. Phosphorus recovery from agricultural drainage can therefore provide a solution to this issue but its recovery from tile drains is challenging because of the low content of P and unpredicted hydraulic loadings. In GreenP, for the first time, extract from grass will be used for the green synthesis of efficient nanoscale adsorbents for the quick and efficient recovery of P from agricultural drainage. The P enriched nanomaterials will be assessed as nano fertilizer for their nutrient release potential, interaction with soil microbial community and translocation within the plant body using high-tech analytical tools and modeling. A multidisciplinary approach connecting environmental engineering, soil fertility, biology, and crop physiology will be implemented. The outcomes will be helpful for better management of P to close its loop in agriculture, thus contributing to the circular economy and agricultural sustainability. The project will also result in a dual exchange of knowledge and expertise between the researcher and the host, which will benefit the professional career of the researcher in the future.

Keywords: agricultural drainage,p recovery,recycling,green synthesis,nanomaterials,nano fertilizer
Revolutionizing Peptein Production for Global Access to Biologics (NUMAPRINT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Numaferm, founded in 2017 in Düsseldorf, Germany, is redefining peptein (peptide and protein) production through fast, scalable, and sustainable biomanufacturing—essentially “printing for biologics.” Initially focused on therapeutic peptides, the company has expanded into pharmaceuticals, food, cosmetics, and animal health. Its mission is to democratize access to pepteins through platform-driven innovation. At its core is Numaswitch, the first biochemical platform for scalable peptein manufacturing, reducing development timelines from up to 24 months to less than 9, cutting costs, and replacing hazardous chemicals with a water-based process. As a leading Contract Development Organization, Numaferm now aims to become a vertically integrated platform company covering the full peptein value chain—from AI-guided lead design to GMP-compliant manufacturing. Patent-protected technologies such as Numaswitch and Numacut, a novel protease for scarless tag removal, strengthen its innovation leadership. This transformation is powered by Numaprint, an automated high-throughput production and analytics platform, and Numax, Numaferm’s proprietary AI engine for construct design and developability prediction. Together, they form a closed-loop system that connects silico design, micro-scale production, and analytical validation, reducing early-stage R&D timelines by up to 50% and costs by up to 90%. Through the EIC Accelerator, Numaferm will industrialize and deploy this unified platform, creating the first end-to-end peptein development solution integrating AI-driven discovery, automation, and sustainable manufacturing. Operating at the intersection of biologics, automation, and AI, Numaferm targets a Total Addressable Market of €100B by 2030, a Serviceable Available Market of €10B, and a Serviceable Obtainable Market of €161M by 2032, positioning the company to lead the next generation of peptein innovation and strengthen Europe’s competitiveness in sustainable biomanufacturing.

Keywords: bioprocessing,protein and peptide production,high throughput screening,automation,ai in biotech,biomanufacturing,gmp manufacturing,modular biotech platform,industrial biotechnology
Marine Renewable Energy Distributed Research Infrastructure - Preparatory Phase (MARINERG-i_PP)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Ireland,France,Italy,Netherlands,Belgium,United Kingdom,Portugal,Spain,Norway,Germany
Call: Preparatory phase of new ESFRI research infrastructure projects (HORIZON-INFRA-2023-DEV-01, 2023)
Start date: 2023-12-01
End date: 2026-11-30
Duration (months): 36.0
Total project cost (EUR): 2820965.32
EU funding (EUR): 2678599.25
Participants: 20
Project status: SIGNED

The MARINERG-i Distributed Research Infrastructure (DRI) unites and consolidates the EU Offshore Renewable Energy (ORE) testing facilities to accelerate development and realise potential of this sector. The world is current undergoing a significant shift in all aspects of energy supply and the vast potential of ORE is being realised and is an intrinsic part of future plans. Through the acceleration of technology development MARINERG-i will provide significant support to achieving the EU Green Deal targets. This will strengthen European scientific and engineering expertise as well as foster innovation in ORE technologies. By consolidating investment in infrastructure and expertise across Europe, MARINERG-i will offer the best quality service and will act as a magnet to attract further funding. Following a successful application, MARINERG-i is one of 11 new Research Infrastructures to be added to the ESFRI 2021 roadmap. The ESFRI European Roadmap for Research Infrastructures, stimulates the implementation of these facilities and arguably contains the best European science facilities based on a thorough evaluation and selection procedure. With Ireland as the lead country MARINERG-i is currently also supported by Belgium, Portugal, Spain and the United Kingdom, with considerable support from institutions within France, the Netherlands, Italy, Norway and Germany. The team are now embarking on a preparatory phase, establishing the legal, governance, scientific and business components required to implement the MARINERG-i DRI.

Keywords: distributed research infrastructure,marine renewable energy,offshore renewable energy,esfri roadmap,green deal,e infrastructure
Building consensus for a new approach to breast cancer prevention in women with a BRCA1 mutation (BRCA-PREVENT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-09-01
End date: 2025-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Women with germline mutations in the BRCA1 genes face a 40-fold increased risk of developing breast and ovarian cancer. As a result, and due to a lack of other options, many women with a BRCA1 mutation choose to undergo drastic risk reducing surgery (removal of both breasts, ovaries and Fallopian Tubes) when they are still very young. Drugs currently recommended for prevention of breast cancer, such as tamoxifen or aromatase inhibitors, do not prevent those cancers with the poorest prognosis, such as triple negative breast cancer. Methods to prevent breast and ovarian cancers in these women are therefore a critical unmet medical need. We and others have identified progesterone as one of the key drivers for triple negative breast cancer development. We have shown that progesterone is consistently elevated during the luteal phase of the menstrual cycle in BRCA1 mutation carriers compared to women without such a mutation, and preliminary data point to progesterone receptor antagonists, such as mifepristone, as a promising class of drugs for primary prevention. Clinical trials of primary cancer prevention are extremely challenging due to the time-gap between the start of the cancer-preventive treatment and the primary endpoints (i.e., cancer incidence and cancer death). Current tools do not predict the likelihood of future cancer development with sufficient accuracy to be used to determine the preventive efficacy of a new treatment. We have developed DNA methylation markers reflecting tissue age and cell type that are increased in cancer tissue as well as in normal tissue from women with a BRCA1 mutation and could be used to monitor preventive efficacy. Clinical trials are now required to further investigate the use of antiprogestins for the prevention of breast and ovarian cancer. This ERC Proof of Concept grant aims to bring consensus among the scientific, patient and regulatory/ethical communities regarding the design and conduct of an initial clinical trial.
Surface and Interface phenomena in sustainable energy storage systems (StoreAGE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Luxembourg,Italy,Belgium,Austria,Germany,United Kingdom,Slovakia
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 3026071.54
EU funding (EUR): 2883924.0
Participants: 18
Project status: SIGNED

Energy storage systems are a crucial part to enable the transformation of our current economic system into a more sustainable one, to balance the fluctuating nature of renewable electricity production from wind and photovoltaics. There are many potential means of energy storage, that differ in their storage capacity and duration, such as batteries or redox-flow batteries. A common factor in all these systems is the importance of processes on surfaces and interfaces that control the involved chemical reactions and physical processes. To improve the current and develop novel energy storage systems, detailed understanding and insight about these surface and interface processes is required. The proposed Doctoral Network will gain insight into these highly relevant surface and interface phenomena. Advanced analytical techniques will be utilized to directly probe chemical and physical processes, relevant for the respective energy storage systems. Modelling and synthetic approaches will complement the understanding of these processes and allow the development of advanced materials and components for energy storage systems. The gained knowledge will be directly applied on real world energy storage systems, provided by the involved industrial partners. As these approaches are highly interdisciplinary, the new generation of researchers has to be trained to excel in such complex research and industrial environments. The proposed Doctoral Network will enable the PhD candidates to combine the most advanced scientific techniques (regarding analysis, modelling and synthesis) with the requirements of modern industry, in the dynamic field of energy storage systems. They will develop a deep scientific understanding of surface and interface processes and also the systemic knowledge to apply their skills in a broad range of industrial environments.

Keywords: storage of renewable energy,metal recycling,sustainable mining
Root2Resilience: Root phenotyping and genetic improvement for rotational crops resilient to environmental change (Root2Res)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: France,United Kingdom,Spain,Netherlands,Italy,Slovenia,South Africa,Ireland,Denmark,Switzerland,Germany,Lebanon,Austria
Call: Breeding for resilience: focus on root-based traits (HORIZON-CL6-2021-BIODIV-01, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 6367651.25
EU funding (EUR): 6367651.25
Participants: 22
Project status: SIGNED

Root2Res will deliver a package of solutions to enhance the resilience of rotational cropping system by considering relevant root traits with respect to the impact of climate change. Innovations will include phenotyping, genetic and modelling tools that will help breeders evaluate, in field and controlled conditions, novel and existing genotypes of a range of crops (Cereals, Potatoes, Legumes) as root ideotypes for different soil and climatic environments across Europe. Root2Res will also investigate the potential role of emerging crops (Sweet potato, Lentil) to enhance resilience to environmental change, by assessing their genotypic and phenotypic variation. The environments targeted include those predicted to suffer from the largest impact of climate change on yield in Europe. Resilience to stress will focus on greater variation in water availability (both drought and waterlogging) and interactions with other stresses (temperature, reduced nutrient availability). We will also consider the impact of novel understanding of the plasticity of traits to stress. Traits to be assessed will focus on exploration, exploitation and rhizosphere microbiome related traits integrated in an extended phenotype. The impacts of the more resilient ideotypes designed in Root2Res on the delivery of climate change mitigation outcomes (soil carbon sequestration, nutrient utilisation and greenhouse gas emission) will be assessed in field. Root2Res will integrate a strong interaction with stakeholders all through the project, particularly breeders and farmers. The ambition of Root2Res is to deliver crops adapted to changing environments and able to mitigate climate change, by utilising existing genetic diversity for breeding programs in a range of crop species essential to cropping systems and then widening understanding to crops suitable for resilient future systems. This ambition will be supported by the joined commitment of a multidisciplinary partnerships across Europe and beyond.

Keywords: extended root phenotype,rotational crops,novel phenotyping tools,water stress resilience,plasticity
Dynamic belief updating in mice, rats, humans and models (DYNABUP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-05-01
End date: 2027-04-30
Duration (months): 36.0
Total project cost (EUR): 276681.6
EU funding (EUR): 276681.6
Participants: 2
Project status: SIGNED

The environment is structured in time, allowing humans and animals to make predictions about the future and adjust behaviour. To this end, they perform ‘dynamic belief updating’ whereby beliefs about event probabilities are iteratively revised in light of new observations. However, this strategy is challenged by two properties of the world, namely stochasticity and volatility. These features imply that an unexpected observation might either simply reflect noise in the generative process or indicate that the process itself has covertly changed. While remedying to stochasticity requires to integrate over past observations so as to cancel out noise from the estimates, the countermeasure for volatility instead dictates to discard past observations so as to compute the most up-to-date estimates. How do humans and animals strike this difficult balance? In this interdisciplinary proposal, I offer to tackle this question using a unique combination of human cognitive neuroscience and rodent neurobiology, all guided by computational modelling. Authorities in these fields (Valentin Wyart, Ph.D. and Benjamin B. Scott, Ph.D.) will provide me with the missing skillset which, combined with my pre-existing expertise, will put me in an unprecedented position to unravel how mammalian brains factor in uncertainty during dynamic belief updating. Notably, I will test the idea that a sensory gain control mechanism gates the impact of novel observations onto past beliefs, and that this sensory gain is tuned by noradrenaline release from the locus coeruleus. The findings will inform neurocomputational theories of learning as well as contribute to a better understanding of cross-species similarities and differences, which is key for more fruitful translational research programs and better optimized use of animals in research. Furthermore, the acquired skillset will ideally position me as an independent researcher equipped with a cutting-edge approach at the frontiers of fields and species.

Keywords: electroencephalography,cognition,cortex,human,inference,learning,locus coeruleus,mouse,optogenetics,probability,rat,sequence,uncertainty,widefield imaging
Pulsed Laser Light and Nano-encapsulated Ocular Dyes for Advanced Therapies in the Eye (DYE-LIGHT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1499351.0
EU funding (EUR): 1499351.0
Participants: 1
Project status: SIGNED

Ocular diseases affect the quality of life of millions of patients. Despite improvements in pharmacological treatments, the arsenal of medications to treat severe ocular diseases today remains rather restricted to traditional drugs. Use of most modern biotherapeutics like proteins and nucleic acids, could be a major step forward. However, current ways of administration such as eye drops and intravitreal injections, are no longer sufficient to deliver these drugs to most targets in the eye. Therefore, novel concepts allowing biotherapeutics to safely overcome ocular barriers are of high interest. In ocular surgery, pulsed-lasers (P-Ls) are used for ‘tissue cutting’, though safety concerns remain. DYE-LIGHT hypothesizes that strategies which would allow the use of P-Ls in the eye at much lower energy than today, could considerably improve safety and pave the way for both novel ocular therapies and advanced surgical interventions. DYE-LIGHT will explore vital dyes, as used by ocular surgeons to stain tissues, as photosensitizers. DYE-LIGHT follows the recent observation that P-L irradiation of ocular dyes can result in the formation of water vapor nanobubbles (‘dye-based nanobubbles’) and thermophoretic transport (‘dye-based thermophoresis’). Interestingly, these biophysical phenomena occur at a laser energy that is ~ 1000 times less than a P-L alone. As compared to free dyes, dyes encapsulated in nanocarriers are expected to penetrate less into the retina, which might improve safety. Therefore, focus in DYE-LIGHT will be on nano-encapsulated ocular dyes. DYE-LIGHT will explore the potential of dye-based nanobubbles for delivery of nucleic acids in the corneal endothelium and for spatial selective vitreolysis in the eye. Finally, DYE-LIGHT will explore dye-based thermophoresis for controlled transport of nanomedicines injected in the vitreous towards the retina. If successful, this might open new perspectives to improve the efficacy of retinal drug and gene delivery.
LEVERAGING THE MICRO-ALGAE TO MAKE MEAT CULTIVATION SCALABLE (Mewery)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Czechia
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Mewery is a biotech deep-tech startup based in Brno, Czech Republic (est. 2021) leading the fortified (with enhanced nutritional value) Cultivated Meat (CM) sector. Our ambition is to be the first to bring cultivated pork to the market. Our vision is to create sustainable food production and, at the same time, to contribute to tackling global climate change by disrupting preconceived ideas about CM. Mewery is bringing a unique scalable method of growing pork cells to global markets. The method is the only one in the world to involve micro-algae in the entire meat cell growth process, creating a simpler, more stable and nutritionally richer product compared to other cultivated and traditionally farmed meat. The development efforts for our products have reached a significant milestones: we have successfully tested the production process in bioreactors, demonstrating the feasibility of our technology for large-scale applications, we have successfully created three prototypes of our end product, which are pork patties weighing 4, 25 and 100 grams. The market keeps changing, and in the coming years, the share of cultivated meat in the whole market will start to play a more significant role. It already started to show its presence in markets like Singapore in 2020, the USA in 2023 or Israel in 2024. Europe is expected to be the next region to demonstrate its attitude towards cultivated meat. We are creating a new market: a fortified cultivated meat market segment, which will be a part of the quickly growing (13% CAGR) cultivated meat market of today’s size of ~$221M (in 2022) and is predicted to grow to ~$593M by 2030 and even to $630B by 2040 as expected by some experts. The major barrier to securing capital to finish development and commercialise our innovation is the need to demonstrate scalable production and test the ease of production along the reasonable CAPEX and OPEX using our future pilot production line, resulting in the attractive price of cultured meat