Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dynamic and evolution of cis-regulatory elements involved in fruit development in Arabidopsis and Brassica (DEHICIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-10-01
End date: 2011-09-30
Duration (months): 24.0
Total project cost (EUR): 170733.61
EU funding (EUR): 170733.61
Participants: 1
Project status: CLOSED

Despite the growing number of transcription factors that play a role in fruit patterning in Arabidopsis, little is known about the molecular interactions that control this fundamental process for plant reproduction. The proposed project focuses on genes and interactions that are relevant for fruit dehiscence. One of these key genes is REPLUMLESS (RPL) which is required for the development of a specialized structure, the replum, involved in the opening process of the fruit to release seeds. RPL functions in part by restricting the expression of SHATTERPROOF (SHP1 and 2), which specify valve margins (another specialized tissue type that surrounds the replum), and JAGGED (JAG), which promotes SHP gene expression. Although closely related, Brassica and Arabidopsis fruits show differences in replum development. Whereas the Arabidopsis replum is about 10 cell files wide, Brassica replum often only consists of 1-2 cell files. This phenotype mimics the phenotype of a weak rpl mutant in Arabidopsis , therefore a further reduction of the replum size in Brassica could give rise to shatter-resistant fruit that would benefit the oilseed rape industry. Our broad goals are to understand whether regulatory changes in RPL, JAG and SHP explain differences in fruit development between Arabidopsis and Brassica, and how further changes could be used to limit pod-shattering in Brassica. We will compare the regulatory sequences of these genes in different species, define cis-elements that mediate the interactions within this regulatory network, test the functional significance of these cis-elements in transgenic plants, then use TILLING to screen for regulatory changes in Brassica. Bridging our knowledge from Arabidopsis to Brassica would give us a great opportunity to study how variations in the regulatory network might generate the subtle differences between the fruits of both species and would have practical applications for reducing seed loss due to pod shattering in Brassica.

Keywords: plant development,fruit,arabidopsis,brassica,cis-elements
The provenance of mosaic tesserae: an interdisciplinary study on Roman Age glass production and trade in Italy (PROMOTE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-09-01
End date: 2011-08-31
Duration (months): 24.0
Total project cost (EUR): 171867.63
EU funding (EUR): 171867.63
Participants: 1
Project status: CLOSED

This project is an interdisciplinary research aimed to improve the knowledge of the Roman age glassmaking industry. The existing reconstruction of the economic model of the ancient glass production derives from the archeological and archaeometric literature and hypothesizes a productive system divided in three phases: firstly the base glass production in few primary glassmaking centers, located in Egypt and in the Near East, in the second stage base glass trading and, finally, the shaping of objects in secondary glass-working centers. Italy lacks in primary glassmaking evidences, but it was demonstrated the suitability of Campania coastal sands to make glass. The problem of location of the primary productive centers and the reconstruction of the trading routes is an open question and this work is aimed to give a contribution for its solution. A specific geographical area, a peculiar type of vitreous materials and a lapse of time were chosen in order to work efficiently. The research is focused in Italy and the materials are the vitreous mosaic tesserae dating from 3rd century BC to 2nd century AD, a meaningful period for the mosaic history. Glass tesserae will be compared to raw materials from Campania and Egypt, the last being a region with a long story of glassmaking tradition and strictly linked to Roman Italy. The characterization will be focused on the analytical techniques useful to trace the provenance of the materials: the stable isotope and the trace elements analysis. Such a kind of characterization is at an initial stage and different techniques will be tested to optimize an effective analytical procedure. The objectives of this work will be improving the knowledge of ancient vitreous materials, experiencing a work procedure to apply the trace and isotope analysis to the ancient glasses and clarifying the origin of the Italian Roman age glasses.

Keywords: archaeology,roman age,glass,mosaic tesserae,archaeometry,stable isotopes,ancient technology,glass trade,vitreous materials,raw materials,glassmaking,coloring agents,opacifiers
Arithmetic of Abelian Varieties (ARITHABVAR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2010-02-01
End date: 2012-04-30
Duration (months): 27.0
Total project cost (EUR): 164269.69
EU funding (EUR): 164269.69
Participants: 1
Project status: CLOSED

The subject of abelian varieties is of central importance in number theory and algebraic geometry. In this proposal, we aim for a deeper understanding of endomorphism rings of abelian varieties (these classify the &apos;symmetries&apos; of the abelian varieties). We will tackle the following four problems: (i) Give algorithms for computing endomorphism rings of abelian varieties ( specified as Jacobians of curves or as modular abelian varieties). (ii) Give a database of abelian varieties and their endomorphism rings. (iii) Give improved bounds for the rank of the Cartier operator on Kummer covers of the projective line and on Artin-Schreier curves in positive characteristic. (iv) Extend the method of Smart and Siksek (a variant of the Diffie-Hellman protocol in cryptography) to suitable quotients of Jacobians by their automorphism groups. The subject of endomorphism rings of abelian varieties is an area of strength for the US, but not for Europe. The incoming fellow, Dr Arsen Elkin, has made outstanding contributions to this subject and the project aims to redress the imbalance between the US and Europe. Moreover, Warwick has outstanding algebraic geometry and number theory groups, but the vital subjects of abelian varieties and arithmetic geometry in positive characteristic are missing from Warwick. The project will introduce and help establish these subjects to Warwick. The project will link Dr. Elkin and his distinguished American collaborators with researchers at Barcelona, Bayreuth, Bristol, Cambridge, Leiden, Leuven, Oxford, Royal Holloway and Warwick.

Keywords: number theory,algebraic geometry,algorithms
Diethynylmetallacyclopentadienes - Investigations of a new class of luminescent organometallics (LUMINESCENT M-CYCLES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-07-01
End date: 2010-06-30
Duration (months): 12.0
Total project cost (EUR): 87067.84
EU funding (EUR): 87067.84
Participants: 1
Project status: CLOSED

The investigation of diethynylmetallacyclopentadienes is of fundamental interest due to their photophysical properties and potential use as organometallic luminophores for organic light emitting diodes (OLEDs) and in 2-photon excited fluorescence/phosphorescence imaging as well as other 3rd order non-linear optical (NLO) applications. Therefore, access to a library of new diethynylmetallacyclopentadienes will be developed and their luminescent behaviour will be examined. As Ir(ppy) complexes have shown the most promise for OLED applications, other metal centres such as Ir and Pt will be employed for the metallacycle formation in order to access triplet luminescence. Furthermore, synthesis of new symmetric and unsymmetric 1,3-butadiynes will be carried out in order to examine the influence of donor/acceptor substitution of the metallacyclopentadienes, which should lead to immense progress concerning the fine-tuning of the luminescence. The influence of strongly donating ligands attached to the metal will aid in understanding the role of the metal centre and will raise the energy of the metal orbitals which is expected to increase the M-L charge transfer component of the optical transition. Theoretical studies and flash-photolysis will be used to obtain information regarding the geometries and electronic structures of the ground and excited states to complete the picture. It is important to gain an understanding of the photophysical properties of the metallacyles through detailed experimental studies in combination with theoretical studies, from which structure-property relationships will be obtained, enabling the design of new metallacycles with specific optical properties.

Keywords: organometallic chemistry,metallacyclopentadienes,fluorescence,phosphorescence,non-linear optics,rhodium,iridium,platinum,cobalt
Experimental Resource for the Investigation of dialogue procesSes (ERIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IOF-2008, 2008)
Start date: 2010-01-01
End date: 2012-12-31
Duration (months): 36.0
Total project cost (EUR): 237878.97
EU funding (EUR): 237878.97
Participants: 1
Project status: CLOSED

The primary goal of ERIS is training-through-research under supervision by two of the world's leading dialogue researchers. This will enable the fellow to expand his repertoire of experimental methods, including obtaining training in specific forms of experimental design, training in statistical analysis, complementary skills training, and exposure to new experimental problems at Stanford and Edinburgh. The vehicle for this training consists of an experimental programme that addresses key problems in dialogue research: the role of clarification requests, acknowledgements, disfluencies, alignment, semantic co-ordination and language change, in dialogue and multilogue. Central to this programme is the development and refinement of the use of text-based dialogue as an experimental methodology into a fully-integrated experimental resource that supports interdisciplinary collaboration between multiple research institutes. It will enable the fine-grained, context-sensitive manipulation of between- and within-turn phenomena of multi-party dialogue. The skills and knowledge acquired during the Outgoing phase, together with feedback from the international distribution network, will be incorporated into the experimental resource, which will include a repository of experimental tasks and interventions. On returning to Edinburgh, the experimental resource will be disseminated to the wider dialogue research community.

Keywords: dialogue,co-ordination,alignment,clarification requests,repair grounding,multilogue
In vivo choreography of DNA molecules and repair proteins during the search for homology. (CHOREOGRAPHY OF HR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IOF-2008, 2008)
Start date: 2010-01-01
End date: 2013-08-01
Duration (months): 36.0
Total project cost (EUR): 242632.79
EU funding (EUR): 242632.79
Participants: 1
Project status: CLOSED

Double-strand breaks (DSB) constantly challenge the integrity of the cellular genome and are important contributors to cancer and genetic diseases. Repair of damaged DNA is a dynamic process that requires careful orchestration of a multitude of enzymes and chromatin constituents that are organized into centers (foci). The outgoing laboratory recently developed powerful methods to explore the dynamics of focus assembly/disassembly in vivo. Using these techniques, I will explore one of the most intriguing steps of homologous recombination: the search for homology. During homologous recombination, the broken DNA searches for intact homologous dsDNA within the entire genome. To elucidate when and how the process of homology search occurs in vivo, I will visualise the movement of a donor and an acceptor sequence, as well as recombination factors, before, during and after double strand break repair. I will take advantage of the elegant yeast genetic system and explore the effects of targeted mutations in key enzymes involved in this process. In the return laboratory, I will to transpose the assay developed in the outgoing laboratory in mammalian cells. With the aid of the Marie Curie fellowship, I propose to spend my post-doctoral period to evolve from single molecule approaches in vitro to genetics and in vivo systems involving multiprotein complexes.

Keywords: cell biology,molecular biophysics,molecular genetics,microscopy,3 d modelling
Beyond local quantum fields: non-commutative field theory and deformed symmetries. (BEYOND LOCAL QFT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-09-15
End date: 2011-09-14
Duration (months): 24.0
Total project cost (EUR): 155832.58
EU funding (EUR): 155832.58
Participants: 1
Project status: CLOSED

Non-commutative quantum field theories and their associated deformed symmetries provide intriguing examples of models beyond the realm of standard local quantum field theory which attempt to introduce basic quantum features of the underlying space-time. The project will focus on a particular model of deformed space-time symmetries, the kappa-Poincare algebra, which provides the prototypical example of non-commutative field theory exhibiting a "built-in" cut-off (Planckian) energy scale and modified energy-momentum dispersion relation. These features make the model particularly appealing from the perspective of extracting potential phenomenological predictions from it. The planned research will focus on developing consistent quantum field theoretic models based on kappa-deformed symmetries and exploring various contexts in which the new structures introduced lead to observable effects. This will be achieved through the study of of particle scattering in general interacting theories and how particle creation phenomena in non-trivial backgrounds are affected by the deformations. To obtain further insights on the general aspects of this and other similar models the researcher will address the issue of providing a rigorous definition of symmetry deformation within the abstract formulation of quantum field theory and will investigate the properties of 'analogue' statistical mechanics models which exhibit similar deformed symmetries. The fellowship will give the applicant the opportunity to return to Europe and to work at the ITP in Utrecht, an internationally renowned center for theoretical and high energy physics to carry out cutting-edge research at the interface of quantum gravity, high energy physics phenomenology, foundational aspects of quantum field theory and mathematical physics.

Keywords: quantum field theory,mathematical physics,relativity,gravitation,statistical physics,cosmology
Neural basis for individual differences in pSTM in the normal and dyslexic populations (NBIDPSTM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-03-02
End date: 2011-03-01
Duration (months): 24.0
Total project cost (EUR): 171867.63
EU funding (EUR): 171867.63
Participants: 1
Project status: CLOSED

Developmental dyslexia (DD) is a hereditary neurodevelopmental disorder, affecting 5%-10% of the population. It is associated with impoverished literacy skills despite normal intelligence and adequate educational opportunities, and occurs in the absence of major sensory impairments. There is currently much interest in the proposal that dyslexia is best characterised as a language-specific deficit in which literacy problems stem from impairment in the representation and processing of phonemes. However, a growing body of empirical evidence fails to support this view. The research proposed here tests an alternative theoretical stance, namely that deficits in phonological short-term memory (pSTM) are central to the literacy problems observed in DD. Within the fields of cognitive psychology and cognitive neuroscience, there have been attempts to further understand the functions and the neural substrate of pSTM. However, fundamental questions concerning the role of pSTM in speech processing remain unanswered and little attempt have been made to translate these basic cognitive science studies to address vital clinical questions, specifically the centrality of deficits in pSTM as opposed to phonological representation and processes in DD. Consequently, the aim of the proposed research is twofold: First, we need to more clearly understand the relationship between phonological processing and pSTM processes and the extent to which they rely upon common or distinct neural substrates before we can establish where the deficit lies in DD. Hence the core components of this proposal focus on this initial step, where we aim to investigate the intersection of pSTM and phonological processing by assessing their overlapping neural networks. Secondly, we aim to extend this and make a step towards translating the results into clinical research addressing the question whether dyslexics’ deficit is more related to one or other, or common substrate impacts upon both.

Keywords: language sciences,cognitive science,neurosciences
Self-assembly of DNA-coated colloidal particles (DNACOLLOIDS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-03-01
End date: 2011-02-28
Duration (months): 24.0
Total project cost (EUR): 163702.68
EU funding (EUR): 163702.68
Participants: 1
Project status: CLOSED

This project aims to use computer simulations to elucidate the structural properties and the phase behaviour of DNA-coated colloids. Several parameters, such as the shape and size of the colloids, the length and flexibility of the grafted DNA, and the number of DNA strands per colloid influence the equilibrium properties of these materials in ways that are, as yet, poorly understood. The applicant, Dr. Mladek, intends to use Monte Carlo simulations to predict the structure and phase behaviour of DNA-coated colloids. To this end she will adapt existing simulation techniques (e.g. umbrella sampling, configurational bias Monte Carlo and thermodynamic integration) to this specific problem. Where necessary, novel MonteCarlo techniques will be developed. It is expected that the proposed project will provide insights that can assist experimental work on the self-assembly of these materials which have many potential technological applications (for instance as photonic band-gap materials). As a first aim, the applicant will explore how DNA-coated colloids can best be designed to serve as building blocks for the self-assembly of non-trivial crystal structures. In this project, the applicant aims to maintain close contacts with the relevant experimental groups, both at the host institution and elsewhere.

Keywords: computational physics,soft matter and polymer physics,statistical physics,thermodynamics
Spatially resolved atom fluorescence imaging (SRAFI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-08-01
End date: 2011-01-31
Duration (months): 18.0
Total project cost (EUR): 162500.62
EU funding (EUR): 162500.62
Participants: 1
Project status: CLOSED

This proposal concerns the implementation of a single atom detector based on the detection of fluorescence photons scattered by atoms when crossing a thin sheet of light during time of flight. Using an EMCCD camera to record the fluorescence signal such system will be used to resolve the position of single atoms for sufficiently low dense clouds. The experimental environment will be the atom chip, a technology which allows the trapping of cold atoms near a surface. After a full characterization of the proposed detection scheme two main investigations will be carried out. First we will study the behaviour of the second order correlation function of freely expanding Bose gases near quantum degeneracy. Taking advantage of the various trap geometries that can be achieved using the atom chip, different regime will be studied. Then, using RF induced double potential, we will create phase cat states and investigate their properties in the context of matter wave interferometry. These two investigations take advantage of the newly designed light sheet fluorescence imaging. The Schmiedmayer research group is an ideal environment in which to carry out this research due to its worldwide-renowned reputation in ultracold gases on atom chips and its new state-of-the-art laboratories at the Atominstitut der Österreichischen Universitäten. This project is also a good opportunity for the fellow to further develop his scientific knowledge in the cold atoms domain.

Keywords: atomic physics,single atom detector,matter wave interferometry