Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Vacuum Medical Device for Safe and Gentle Cervix Grasping Gynecological Applications (Aspivix)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-11-01
End date: 2022-01-31
Duration (months): 27.0
Total project cost (EUR): 3560097.5
EU funding (EUR): 2492068.25
Participants: 1
Project status: CLOSED

For years, gynecologist practices related to Intra-Uterine Contraceptive Device (IUD) insertions, curettage and several other common indications, have featured poor care and low attention to female patients. The use of the Tenaculum, grasping and pulling on the cervix, inside the vaginal cavity, proved to be painful and traumatic for 84% of the women, and eventually to trigger lesions and bleeding in 29% of the patients, as well as cross-contamination in 5-10% of the women. These disadvantages refrain the use of IUD contraceptive which exacerbates the unintended pregnancies, sized yearly in 85 mills and representing billions of euros in social costs worldwide. In response, we have developed Aspivix, a new disruptive gynecological device that reduces the pain and eradicates the bleeding during the exploration procedure. Our patented device will replace the Tenaculum forceps, unchanged for over 100 years, to provide gynecologists an easy-to-use device where gentle and firm cervix uterus grasping and traction is needed. Thus, our device will facilitate the adoption of IUD, which could avoid up to 8% of unintended pregnancies and reduce derived social costs. Besides, Aspivix is intended for a single use which prevents the risk of contamination and cross-infection. Overall, Aspivix has the potential to shorten the intervention procedure (2 steps instead 7), which will represent for the physician a 28% economic benefit. As result, Aspivix will fulfill the needs of more than 64 M of women worldwide/year, a market that is projected to grow at a CAGR2016-2021 of ~6.5% due to the high demand of IUD insertions and is valued in more than €385M.

Keywords: medical device,unintended pregnancies control,gynecologist practices,women empowering
Molecularly Imprinted Photocatalytic light-driven micro/nanomotors for selective degradation and detection of pollutants in water and food (MIPhmotors)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Czechia
Call: Widening Fellowships (H2020-WF-03-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 156980.64
EU funding (EUR): 156980.64
Participants: 1
Project status: CLOSED

In recent years, the use of toxic pesticides in agriculture has been intensified to fulfill the increasing demand for food, at the expense of a heavily polluted environment. Growing of food using polluted water causes serious risks for human health. Therefore, Europe has introduced increasingly stringent regulations on food production quality, which require a sensitive and selective screening system that can detect pesticides in water and food. Micro/nanomotors, combining the enhanced physicochemical properties of micro/nanoscale materials with their autonomous motion capability, have demonstrated a great potential for the fast degradation of pollutants into electrochemically detectable products. Still, there is no control on their degradation ability, as they "shoot and degrade" any pollutant on their path, leading to a non-selective detection. Moreover, the motion is generally achieved by using toxic fuels or through the decomposition of motors themselves, limiting their practical applications. The present MSCA IF project "MIPhmotors" aims to selectively and sensitively detect toxic pesticides in water and food by employing for the first time the molecular imprinting technique for the preparation of photocatalytic micro/nanomotors with various sizes and shapes. This innovative class of motors will be able to exploit a renewable and abundant resource as light to move and, at the same time, selectively photodegrade the imprinted pesticide via the specific recognition sites created by molecular imprinting. Then, the electro-active degradation product will be detected by electrochemical measurements using commercial screen-printed electrodes. The proposed research activity can be extended for the detection of other pollutants, and will open new opportunities in the field of micro/nanomotors and in their application for water purification, sensing and biomedicine.

Keywords: nanomaterials,micromaterials,photocatalytic semiconductors,molecular imprinting,photodegradation,electrochemistry,sensors,pesticides
CyberSEAS: Cyber Securing Energy dAta Services (CyberSEAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Improve cyber security
Action type: Innovation actions
Countries involved: Germany,Italy,Germany,Spain,Estonia,Italy,Italy,Germany,Spain,Italy,Romania,Finland,Croatia,Slovenia,Slovenia,Belgium,Greece,Greece
Call: Cybersecurity in the Electrical Power and Energy System (EPES): an armour against cyber and privacy attacks and data breaches (H2020-SU-DS-2020, 2020)
Start date: 2021-10-01
End date: 2024-09-30
Duration (months): 36.0
Total project cost (EUR): 10066367.03
EU funding (EUR): 7999113.64
Participants: 29
Project status: SIGNED

CyberSEAS (Cyber Securing Energy dAta Services) ambition is to improve the resilience of energy supply chains, protecting them from disruptions that exploit the enhanced interactions and extended involvement models of stakeholders and consumers in complex attack scenarios, characterised by the presence of legacy systems and the increasing connectivity of data feeds. It has 3 strategic objectives: 1) countering the cyber risks related to highest impact attacks against EPES; 2) protecting consumers against personal data breaches and attacks; and 3) increasing the security of the Energy Common Data Space. All three objectives are equally important, since cyber-criminals are shifting tactics to favour multi-stage attacks in which stealing sensitive data is a precondition for the real attack, and enables them to maximise damage and profits (while traditionally infrastructure cyber-attacks used to be direct attacks to the machinery and typically targeted control systems, not data). Threat actors, especially large ones such as nation states, also carry out complex attacks that leverage supply chain dependencies, and this trend continues to grow, as highlighted in the July 2020 analysis by the Atlantic Council. Likewise, with the transition to scenarios where users are proactively involved, prosumer data is becoming more and more sensitive. To achieve these objectives, CyberSEAS delivers an open and extendable ecosystem of 30 customisable security solutions providing effective support for key activities, and in particular: risk assessment; interaction with end devices; secure development and deployment; real-time security monitoring; skills improvement and awareness; certification, governance and cooperation. CyberSEAS solutions are validated through experimental campaigns consisting of 100+ attack scenarios, tested in 3 labs before moving out to one of 6 piloting infrastructures across 6 European countries. Out of the 30 solutions, 20 will reach TRL8+ and 10 TRL7.
Massive Reverse Genomics to Decipher Gene Regulatory Grammar (MRG-GRammar)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Israel,Germany,Sweden,United Kingdom,United Kingdom
Call: FET-Open research projects (H2020-FETOPEN-2014-2015-RIA, 2014)
Start date: 2015-08-01
End date: 2018-07-31
Duration (months): 36.0
Total project cost (EUR): 3999661.0
EU funding (EUR): 3999661.0
Participants: 7
Project status: CLOSED

MRG-GRammar aims to devise an entirely new strategy for deciphering the regulatory rules of gene regulation. We will leverage Synthetic Biology with cutting-edge DNA synthesis technologies and high-throughput analysis to generate new types of biological datasets that systematically explore all possible regulatory landscapes rather than just the naturally occurring regulatory sequences. The extensive and unbiased nature of these unique datasets will allow us to build new models explaining different aspects of regulatory activity, which will be tested in second-generation libraries, designed based on model predictions. Consequently, through such an iterative process, we expect to make a significant breakthrough in deciphering, and evolving, the regulatory code. Our strategy synergizes four orthogonal objectives that will form a new knowledge base from which the regulatory algorithm can be derived. We will employ our strategy on diverse model organisms from the tree of life, from single cell to whole organism: bacteria, yeast, mouse ex-vivo cells, human cell-lines and finally, whole D. melanogaster and mouse embryos. We expect this multidisciplinary synthetic biology approach to generate a major technological advance, which will provide the community with algorithms that will not only decipher extant natural regulatory code, but also interpret variations leading to a profoundly deeper understanding of the origins of many diseases. We expect our models to also serve as a reference in designing and implementing accurate and more controllable synthetic biology devices, with applications in fuel production, healthcare and other industrial fields. Thus, our ultimate goal is to substantially accelerate the advance of technologies and knowledge related to generating systematic and personal therapeutic solutions based on the analysis of each individual's natural genomic variations.

Keywords: synthetic biology dna synthesis genomics regulation
Structure-dependent microkinetic modelling of heterogeneous catalytic processes (SHAPE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2021-10-31
Duration (months): 66.0
Total project cost (EUR): 1496250.0
EU funding (EUR): 1496250.0
Participants: 1
Project status: CLOSED

Despite the fact that the catalyst structure has been an important factor in catalysis science since the discovery of structure sensitive reactions in single crystal studies, its effect on reactivity is neglected in state-of-the-art microkinetic modelling. In reality, the catalyst is dynamic by changing its structure, shape and size in response to the different conditions in the reactor. Thus, the inclusion of such effects within the framework of microkinetic modelling, albeit extremely complex, is of outmost importance in the quest of engineering the chemical transformation at the molecular level. This proposal aims to approach this grand challenge by developing a hierarchical multiscale methodology for the structure-dependent microkinetic modelling of catalytic processes in applied catalysis. In particular this challenging objective will be achieved by acting on two main fronts: i. development of a hierarchical multiscale methodology for the prediction of the structural changes of the catalyst material as a function of the operating conditions in the reactor and the analysis of the structure-activity relations through the development of structure-dependent microkinetic models; ii. show the applicability of the methodology by the assessment of the structure-activity relation in the context of relevant processes in energy applications such as the short-contact-time CH4 reforming with H2O and CO2 on supported-metal catalysts. The inherent complexity of the problem will be tackled by hierarchically combining novel methods at different levels of accuracy in a dual feed-back loop between theory and experiments. This will require interdisciplinary efforts in bridging among surface science, physical-chemistry and chemical engineering. The fundamental nature and impact of the methodology will be unprecedented and will pave the way toward the detailed analysis and design of the structure-activity relation by tuning shape and size to tailoring activity and selectivity.

Keywords: heterogeneous catalysis,microkinetic modeling,multiscale modeling,chemical kinetics,methane reforming,metal catalysts,structure sensitivity
Joining Efforts for Responsible Research and Innovation (JERRI)

Framework: Horizon 2020 — Science with and for Society
Programme: Integrate society in science and innovation issues, policies and activities in order to integrate citizens' interests and values and to increase the quality, relevance, social acceptability and sustainability of research and innovation outcomes in various fields of activity from social innovation to areas such as biotechnology and nanotechnology
Action type: Coordination and support actions
Countries involved: Austria,Germany,Netherlands,United Kingdom
Call: Supporting structural change in research organisations to promote Responsible Research and Innovation (H2020-ISSI-2015-1, 2015)
Start date: 2016-06-01
End date: 2019-05-31
Duration (months): 36.0
Total project cost (EUR): 2363643.75
EU funding (EUR): 2363643.75
Participants: 5
Project status: CLOSED

The goal of the project is to foster RRI transition in Europe by developing and testing good RRI practices in pilot cases, for a further upscaling among the RTOs in the EU28. A Responsible Research and Innovation (RRI) Plan will be developed and implemented at the biggest European RTOs, the Fraunhofer-Gesellschaft and TNO, covering the five RRI key dimensions (societal engagement, gender equality and gender in research and innovation con-tent, open access, science education and ethics). After identifying the state-of-the-art of good RRI practices, goals will be developed for within each dimension. Barriers for the achievement of these goals will be analyzed, and an action plan to overcome these barriers will be formulated. The project will be set up as a mutual learning process between the consortium, further European RTOs, stakeholders, and two international associated partners.
An adaptation-based approach to understand resilience after job loss: Identifying the underlying mechanisms leading to adaptive coping and re-employment (ADAPT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Unemployment represents a major societal problem in Europe, strongly related to increasing depression and anxiety rates and high economic costs. In line with European policies on mental health, enhancing resilience against the adverse effects of job loss is a timely priority. In ADAPT, I propose a novel framework and advanced methods to identify the psychological mechanisms (adaptation-based attention and emotion regulation processes) promoting adaptive coping after job loss and facilitating higher possibilities for re-employment. ADAPT is highly original and timely for current societal needs, providing: a) a novel framework beyond traditional approaches in the study of resilience, largely failing to provide successful mental health promotion deliverables; b) fine-grained analyses of adaptation-based mechanisms that can be easily targeted in future assistance protocols; c) integrative analyses of both positive and negative resilience outcomes typically studied in isolation; and d) analyses of dynamics at both short- (immediate daily functioning following layoff) and long-time scales (multi-wave follow-ups across the months following job loss), providing a whole view on the stress-resilience trajectories following unemployment that is lacking in former research. The proposal includes a well-defined program of two-way transfer of knowledge including high-quality training in new advanced techniques for the candidate. ADAPT represents an actual attempt to reach relevant stakeholders in the social assistance and mental health sectors to develop innovative programs of mental health’s promotion. The action will generate knowledge that can be ultimately used to develop interdisciplinary deliverables, including advanced e-tools for early detection of sources of conflict following job loss and guidelines for outplacement services on effective strategies and training protocols to promote adaptive functioning in unemployed seeking assistance.

Keywords: unemployment,resilience,stress,depression,anxiety,well being,attention regulation,emotion regulation,reappraisal,rumination,coping
Methodology for efficient segmenting innovating SMEs based on lifecycles, represented sectors and regional characteristics (SMEthod)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Research and Innovation actions
Countries involved: Spain,Cyprus,Poland,Finland,United Kingdom,United Kingdom
Call: Innovating SMEs - segmentation along lifecycle and sectors (analytical research activity) (H2020-INNOSUP-03-07-08-2017, 2017)
Start date: 2017-12-15
End date: 2020-06-14
Duration (months): 30.0
Total project cost (EUR): 988965.0
EU funding (EUR): 988965.0
Participants: 7
Project status: CLOSED

SMEthod is a research project aimed at delivering an improved methodology of identifying SME’s pathways to innovation and of segmenting innovating SMEs in order to determine optimal targeting and timing of support measures allocated by innovation agencies and other institutions. A complementary goal is to create a decision support tool (DST) ) which will be devolved in cooperation with the relevant stakeholders who implement innovation policies and by compiling the complex SME innovativeness determinants will offer them a flexible evaluation tool. Broad dissemination activities are also planned to reach innovation stakeholders, innovation and regional development agencies, ministries, etc. The SMEthod methodology will consider important factors that are likely to influence companies and the societal impact they create. In particular, enterprise lifecycle, industrial sectors, regional characteristics, and innovation cycles will be scrutinized. New segmenting criteria for innovation support policies will be prepared and specific variables will be determined and weighted in order to assure usability of the methodology. The holistic character of the project will be assured by proposing a more efficient allocation of appropriate pro-innovation measures. Most common and relevant methodologies of segmenting SMEs for the purpose of innovation support will be evaluated as well. Furthermore, efficiency of selected methods and techniques will be assessed. Conclusions from the research will be merged to deliver a final product of the project – a holistic methodology and the DST based on it. The project’s impact will be a better understanding of innovation dynamics and potentials in SMEs and of their efficient segmentation. New knowledge will be created on the effectiveness of innovation policies and most popular measures. Better targeting different instruments toward most promising SMEs will be possible thanks to evaluative analyses and new segmenting criteria.

Keywords: methodology of companies segmentation,innovation support,smes,enterprise lifecycle,industrials sectors,regional characteristics,social impact,data analysis
A powerful and efficient tissue regeneration method for reducing the anastomotic leakage rate in gastrointestinal surgery (OBSIDIAN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2021-05-01
End date: 2024-04-30
Duration (months): 36.0
Total project cost (EUR): 3058250.0
EU funding (EUR): 2140775.0
Participants: 1
Project status: SIGNED

For more than 4 years, Vivostat® together with Rivolution® have been working to develop Obsidian ASG® with the aim to reduce anastomotic leakage in gastrointestinal (GI) surgery. Obsidian ASG® is a best-in-class autologous bioactive fibrin matrix with sustained release of active cells and growth factors providing improved sealing and healing. A preliminary retrospective, single-arm study with 261 patients from two participating colorectal units in Austria, indicate that application of Obsidian ASG® at anastomotic site following colorectal resection is safe and associated with a low rate of anastomotic leakage of 2.3% (1). Obsidian ASG® may therefore reduce leakage by more than 50% in gastrointestinal resections. Gastrointestinal resections often results in anastomotic leakages: • In Europe more than 450.000 new cases of colorectal cancer every year - most of these will undergo anastomosis surgery • In up to 19% of gastrointestinal surgeries the resection results in anastomotic leakage making it one of the most dreaded complication following GI surgery • The cost per patient experiencing anastomotic leakage is up to 4 times higher compared to an uncomplicated procedure The EIC Accelerator funding allows Vivostat® to conduct a large-scale multicenter clinical trial across the EU (up to15 hospitals in 7 countries) with inclusion of approximately 440 patients. The main objective of the study is to investigate whether the application of Obsidian ASG® during colorectal resection reduce the rate of postoperative anastomotic insufficiency compared to standard anastomotic technique. Market access and reimbursement strategy with focus on Germany, marketing strategy with product launch plans as wells market expansion plans are also key elements in the project. These activities will strengthen and accelerate the commercialization of Obsidian ASG® to the benefit of patients, surgeons, hospitals as well as job creation. (1) Shamiyeh et al. Obsidian ASG ® Autologous Platelet Rich Fibrin Matrix and Colorectal Anastomotic healing: A Preliminary Study. Surgical Technologies International, Volume 39, 2021.As a result, Obsidian ASG® will save thousands of lives by reducing anastomotic leakages, decrease the immense global healthcare care spending, and generate an accumulated revenue of EUR 53,49 million 5-year post-project for Vivostat.

Keywords: regenerative medicine,minimally invasive surgery,colorectal cancer,colon cancer,anastomotic leak,bowel surgery,bowel resection