Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SYSTEMS BIOLOGY APPROACH TO PREDICTING OUTCOMES OF LUNG CANCER THERAPIES AND STRATEGIES TO OVERCOME DRUG RESISTANCE IN VITRO. (SYSBIODREZ)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-05-01
End date: 2016-04-30
Duration (months): 24.0
Total project cost (EUR): 269743.8
EU funding (EUR): 269743.8
Participants: 1
Project status: CLOSED

There has been extensive research dedicated to identifying predictive biomarkers of tumor sensitivity to ligand-based therapies. Although some biomarkers have emerged, there is still no comprehensive understanding that unifies the observed tumor cell type-specific behaviors, in particular the differential responses to anti-cancer drugs. The collective realization is that no single protein measurement is predictive of therapeutic outcome. Large-scale studies focusing on multiple genetic biomarkers may be partially inadequate given the observed fractional killing of genetically-identical clonal cell populations. The objective of this proposal is to address this deficiency by coupling high-content analyses (dynamic live cell imaging, high-throughput assays) with theoretical and computational methods to provide a global understanding of the origins of tumor cell heterogeneity in response to anti-cancer drugs that target the apoptotic signaling pathway at the receptor level. Ultimately this approach will serve to identify, on a tumor cell type basis, the most predictive set of biomarkers and design optimal therapeutic combinations.

Keywords: lung cancer,apoptosis,drug resistance,cell signaling,computational biology,modeling.
Stochastic Parametrizations in Complex Systems (SPARCS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2015-02-25
End date: 2018-02-24
Duration (months): 36.0
Total project cost (EUR): 274336.8
EU funding (EUR): 274336.8
Participants: 2
Project status: CLOSED

Our society increasingly relies on numerical atmospheric models to predict extreme events such as intense storms or rare flow regime changes such as those leading to heat waves. Yet, how well these events can be reproduced with those models is currently unknown. In this project, we will make use of advances in the mathematics of stochastic differential equations to determine how the presence of delayed feedback influences the rates of rare transitions between flow regimesand the separation of nearby trajectories in geophysical fluid flows. Delayed feedbacks are an essential element of systems without a time scale separation, such as the atmosphere. This study is possible due to recent extensions of large deviation theory to systems with delay. We will also determine how approximations of dynamical systems influence the distributions of extreme events. Here we will use the theory of extreme values in dynamical systems that has been developed in the last few years and finite Markov approximation of the transfer operator. Together these results will greatly advance the understanding of how complex systems such as the Earth system can be simulated.

Keywords: geophysical fluid dynamics,delay equations,large deviations,extreme value theory,local lyapunov exponents,rare transitions,approximation of transfer operators
Phenomenology of Heavy Ion Collisions at RHIC and the LHC (HICATLHC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-17
End date: 2016-09-16
Duration (months): 24.0
Total project cost (EUR): 166336.2
EU funding (EUR): 166336.2
Participants: 1
Project status: CLOSED

Relativistic heavy-ion collisions probe the fundamental structure and behavior of matter at the highest temperatures ever achieved. Results from the Relativistic Heavy Ion Collider (RHIC) have demonstrated the creation of a strongly interacting, deconfined Quark-Gluon Plasma (QGP). New data, especially from higher-energy collisions at the Large Hadron Collider (LHC) will soon provide an opportunity to quantify properties of the QGP medium, as well as to characterize the non-equilibrium dynamics of the early stages of a collision. It is proposed to use state-of-the-art phenomenological tools to extract such precise quantitative information from these new experimental data.

Keywords: relativistic heavy-ion collisions,quark-gluon plasma,qcd,nuclear physics
Yugoslavia Revisited: Post-Yugoslav Literature and Art as Curators of the Socialist Past (YUGOSLAVIA REVISITED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-02-01
End date: 2017-01-31
Duration (months): 24.0
Total project cost (EUR): 183469.8
EU funding (EUR): 183469.8
Participants: 1
Project status: CLOSED

This interdisciplinary project aims to investigate how post-Yugoslav literature and art remembers the heydays of socialist Yugoslavia (1950s-1970s) and how these acts of remembrance critically intervene in the public sphere. Focusing on a number of selected cases from prose fiction, film, visual art and performance/theater, the project will not only scrutinize how the arts ‘archive’, ‘document’ or ‘recall’ the everyday life and memory of socialist Yugoslavia, but also examine how critical cultural practices and the memories they mediate help envision a better future and open up new avenues to cosmopolitanism. Utilizing a dynamic understanding of cultural memory as a performative engagement with the past, this project will center on the following questions: (1) How do post-Yugoslav artistic practices act as curators of the socialist past in opposition to the dominant ideologies of nationalism and neoliberalism? (2) How does post-Yugoslav literature and art acknowledge the mediated character of memory? (3) How do the ways in which the arts shape and circulate the cultural memory of Yugoslavia help transcend national and ethnic boundaries and imagine new forms of solidarity? (4) How do literature and art deal with the issue of Europe and transnational identity, and how is this reflected in their reception? The cultural memory of the multinational socialist Yugoslavia, of its utopian potential as well as of its violent breakdown, has broad repercussions that strongly resonates with the endeavor of the European Union to create a shared European identity based on a common understanding of the (European) past. By providing an analysis of post-Yugoslav artistic practices of cultural remembering, the project will produce new knowledge on this specific case, provide a theoretical contribution to cultural memory studies, and contribute to broader current debates on a common European cultural memory and transnational identity.

Keywords: cultural memory studies,socialist yugoslavia,literature and visual art,transnational identity,european memory
New Cosmological Standard Candles from Gamma Ray Burst Correlations (COSMOLOGICAL CANDLES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 272285.4
EU funding (EUR): 272285.4
Participants: 1
Project status: CLOSED

Gamma Ray Bursts (GRBs), the most powerful and distant objects ever observed so far, are fascinating objects due to their still unexplained relativistic outburst mechanism. GRBs are observed much further than SNe Ia, which are the most robust probes of the accelerating Universe and whose discovery was awarded the Nobel Prize in 2011. For this reason, GRBs can be used to test cosmological models. Discovering universal relations linking observable GRB properties is a basic step toward using them as precise distance indicators for cosmological applications. To this end, it is crucial to understand if they can be considered standard candles (astronomical objects whose luminosity is known or can be derived from other distance-independent observable) as SNe Ia and thus can be used as precise distance indicators for testing cosmological models. However, GRBs seem to be far from standard candles, with their energies spanning over eight orders of magnitude. Therefore, investigating relations between important GRB characteristics will shed light not only on their use as possible standard candles, but can also provide new constraints for the physical model of the GRB explosion mechanism. The project aim is to update in a multiwavelength range, from 0.3 keV to GeV, the luminosity-time correlation (LxTx) for GRBs (known in the literature as Dainotti relation) and identify a subclass of GRBs with well -defined properties and bias-free, namely corrected by redshift evolution and selection effects due to instrumental threshold through the Efron and Petrosian (1992) method. This subclass will be the candidate for GRBs standard candles. The bias-free LxTx correlation might be the basis for a new independent and powerful cosmological tool. Finally, the challenge is to use the LxTx correlation together with other correlations, both corrected for selection bias in order to discriminate among theoretical models, to use them as cosmological tools and valuable redshift estimators.

Keywords: astrophysics,gamma-ray bursts,cosmology,standard candles,high energy astrophysical processes,theoretical models
Direct measurements of surface potential and charge of a single mineral nanoparticle in water by particle-impact nanoelectrochemistry (PARTICLE IMPACT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-01-05
End date: 2017-01-04
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

The proposed project will establish a method for direct measurement of surface potential of single mineral nanoparticles in an aqueous solution as they collide with a stationary microelectrode. The particle-impact approach described in the proposal is a revolutionary approach for in situ analysis of mineral/water interfacial chemistry and a significant step forward from the state of the art of the colloid and interfacial science especially in the field of geochemistry. Hydr(oxo) functional groups at metal oxide surface serve as the reaction centers for electrostatic or hydrogen-bonded adsorption of ions that are of particular importance in combatting environmental pollution and for energy security issues. Surface potential and charge are the most prominent intrinsic properties describing surface activity; however, neither parameter is a measurable by today’s interfacial analysis techniques. Instead, various surface complexation models are used to extrapolate experimental results of the mineral surface's proton uptake/release behavior to compute these parameters. Current approach suffers from low precision and accuracy due to number of uncertainties raised from both experimental and morphological aspects such as synthesis techniques and particle coagulation. Hence, there is a strong need for direct measurements of a single nanoparticle. The applicant (Ph.D. in 2008) has years of experience conducting research in electrochemistry and mineral/water interfacial chemistry in multi-national and cultural environment, and the host is one of the pioneers of the particle-impact approach. During the fellowship, He will be provided with training for conducting experiment using the particle-impact approach and effective student supervision and project management as well as exposure to the industry sector. This training program marks the final step towards his research maturity and a professorship.

Keywords: partilce-impact chronoamperometry,metal oxide,hematite,surface potential,mineral/water interface,nanoparticle
Ways of Doxastic Agency: Information Update, Belief Formation and Assessment of Conduct. (WADOXA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 175974.6
EU funding (EUR): 175974.6
Participants: 1
Project status: CLOSED

In social interactions, where agents act together and exchange information, inefficiency in updating information and forming beliefs can have dramatic effects; as a consequence, individuals are often assessed on the ground of their reliability and care in getting new information and forming beliefs. In such situations, we need a clear understanding of the dynamics connecting information update and belief formation to conduct, on pain of producing unfair assessments. The analysis of such dynamics has followed two main alternative approaches: logics of agency, which study what agents can ensure with winning actions and its relation with the agents’ knowledge, and logics of information change, which study how information update may solve uncertainty and change what we believe about the world and about other agents’ beliefs. Each of the two traditions accounts for separate aspects of the connection between information and conduct, while neglecting others. The project Ways of Doxastic Agency: Information Update, Belief Formation and Assessment of Conduct (WADOXA) will provide a unified framework treating both information update and exertion of choices as complementary aspects of the entwinement between epistemic performance and conduct. Also, the project will result in a systematic theoretical framework consisting in a Conduct Assessment Theory. The theory will give a rigorous expressions to criteria for the assessment of the agents' conducts on the ground of the agents' epistemic performance. Also, it will propose a descriptively adequate model for the distribution of cognitive labor, that is the phenomenon at stake when belief is acquired by testimony. This will be done by delivering mathematical tools to analyze the logical properties of the new conceptual framework and the emerging notions.

Keywords: information update,belief formation,assessment of conduct,reliability of belief formation,distribution of cognitive labour,dynamic epistemic logics,'seeing-to-it that' logics.
In the search of non-authoritative education in Hungary. Metadiscourses, identities and strategies in students’ and teachers’ interactive practices in standard and alternative settings (FINDING OWN WORDS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-04-01
End date: 2016-03-31
Duration (months): 24.0
Total project cost (EUR): 207613.2
EU funding (EUR): 207613.2
Participants: 1
Project status: CLOSED

As previous studies have proved, a majority of teachers maintain authoritative practices in Hungarian classroom discourses. Instead of behaving as independent agents, students often play the role of a patient, paraphrasing textbook definitions and their teachers’ words. This condition of dependence is usually reflected in students’ narratives, and classroom observations confirm this impression. Has classroom interaction in Hungary become more democratic after the fall of communist dictatorship (1989)? Previous studies suggest that in the case of mainstream state schools, the answer is no. However, from the end of the 1980s, there was a period of the rise of experimental programs in Hungary. CLIL (Content and language integrated learning) programs became popular, but did not become part of the mainstream, since they regularly serve the goals of elite training. It is unfortunate, because – as P. A. Duff has argued –, CLIL practices may promote democratic principles. CLIL may be intertwined with more active student participation and symmetric interaction than standard teaching. Based on large corpora collected in standard (state mainstream) and alternative (CLIL and experimental) settings, recorded classroom discourses and interviews will be compared. The systematic CA and DA analysis of classroom discourse and teachers’ and students’ narratives on their school experiences will serve a better understanding of institutional language policies, speakers’ identities and roles of agency. These are the piers of the cultural and linguistic socialization in a school, and their analysis supports the preparation of pedagogical innovations. The host institution’s expertise in CLIL and FL studies is inevitable for a better understanding of Hungarian formal training, and the role of metalanguage in the achievement of Hungarian students. The results will be used for the elaboration of non-authoritative learning environments.

Keywords: learning environments,classroom interaction,agecy,speaker's identity,l2 and l3 acquisition,narratives,discourse analysis,content and language integrated learning,democracy in school system
Identification and characterization of novel EGFR interactors and their implication in cancer signalling (CANCER SIGNALLING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-03-10
End date: 2016-03-09
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

One of the major challenges of modern molecular biology is to understand how healthy cells transform into malignant, proliferating cells leading to diseases such as cancer and which proteins trigger these aberrant signalling cascades. The ErbB family of receptor tyrosine kinases (RTKs) are pivotal mediators of the signalling network that transmit extracellular signals into the cell and control cell growth, proliferation, differentiation and survival. Excessive ErbB signalling arises from receptor overexpression or mutation and is a hallmark of various cancers. Yet, despite 25 years of in-depth studies of RTK signalling, some aspects remain elusive and deeper understanding of signalling pathways downstream of mutant receptors will likely improve current EGFR-targeted therapies. Hence, the main aim of this proposal is to identify novel players in EGFR signalling as potential novel cancer drug targets. This will be achieved by transferring a novel two-hybrid technique that I have developed during my previous postdoc to the host institution and combining it with their expertise in cancer signalling. I will a) perform interaction screens to identify novel interactors of EGFR and its cancerous variants and b) perform small molecule compound screens to identify drugs that can interfere with interactions that specifically occur with these oncogenic EGFRs. Our ultimate goal is to identify chemical compounds that can be taken further to therapeutic development.

Keywords: protein-protein interactions,two-hybrid technology,egfr signalling,cancer signalling,high-throughput small molecule compound screening
Evolution of jaws and teeth - new insights into key innovations and the origin of Gnathostomes (TOOTHJAW)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-10-01
End date: 2016-09-30
Duration (months): 24.0
Total project cost (EUR): 299558.4
EU funding (EUR): 299558.4
Participants: 1
Project status: CLOSED

The emergence of jawed vertebrates (gnathostomes) is a pivotal event in vertebrate evolution, based on the evolution of jaws with teeth. This was thought to represent a key vertebrate innovation, allowing jawed vertebrates to outcompete their jawless rivals. Recent discoveries however, shed a different light on the evolution of teeth and jaws. i) tooth-like structures were found on gill arches in a primitive jawless vertebrate, indicating that teeth evolved prior to jaws. ii) the first jawed vertebrates appear to be toothless. These data demonstrate that tooth and jaw evolution were not coordinated, contradicting previous scenarios. Among living gnathostomes, the two major groups are chondrichthyans (shark, rays) and osteichthyans (bony jawed vertebrates). Crucially, we lack insight into the development of teeth and jaws in early osteichthyans. Our current knowledge is based only on two members of this clade, representing two important laboratory models: the Zebrafish, an actinopterygian, and mouse, a sarcopterygian tetrapod. These are the two fundamental lineages that comprise Osteichthyes, diverging 400+ million years ago. However, zebrafish and Mouse are derived osteichthyans, and not representative the early osteichthyans. The question of how vertebrate jaws and teeth evolved is best answered in a multidisciplinary approach, providing necessary phylogenetic and developmental context to interpret data from basal osteichthyans. Only then can we find new hypotheses of how complex modules evolved. My proposed project offers a rare opportunity to investigate evolution and assembly of a jjaws and teeth. A pivotal part of this project will employ cutting edge 3D imaging techniques to analyze fossil data, essential because organisms in which these modules first evolved are long extinct. Only data fossil jawed vertebrates can answer the specific question of how jaws and teeth evolved, fundamental to understanding jawed vertebrate origins, and thus, our own evolution.

Keywords: tooth,jaw,evolution,gnathostomes,3d imaging,srxtm,phylogeny