Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Design of glycan epitope toolbox: a novel pathway for protein N-glycosylation in the E. coli cytosol (Glycoli)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-11-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

Metabolic engineering of E. coli has been highly successful in producing diverse free oligosaccharides for research and commercial applications. Currently, we are poised to address the next major challenge: the site-specific synthesis of oligosaccharides directly onto proteins in the E. coli cytosol. In this project we aim at the metabolic engineering of an N-glycosylation pathway in the E. coli cytosol using heterologous glycosyltransferases (GTs) to produce defined glycoprotein structures. Starting point is the newly discovered family of cytosolic N-glycosyltransferases (NGT), which transfer a single glucose residue onto proteins at asparagine (N) residues in the N-X-S/T sequon. Co-expression of an NGT with a galactosyltransferase has been shown to yield N-linked lactose in the E. coli cytosol. This N-linked lactose is an ideal starting point for the design of cytosolic N-glycosylation pathways to synthesize important glycans on proteins. Two goals are delineated. 1) Bacterial GTs will be screened, and potentially engineered, for their ability to extend the N-lactose with defined sugars, thereby generating a diverse repertoire of glycans directly synthesized on proteins. The focus will be on screening of fucosyltransferases and efficient production of fucosylated oligosaccharides, as these are central glycan epitopes in diverse physiological processes. 2) The newly developed glycosylation pathways will be applied to a range of protein substrates in order to explore and address possible limitations of the glycosylation system. The result will be a well-characterized glycoengineering toolbox enabling the bottom-up production of defined glycoprotein structures in E. coli.

Keywords: metabolic engineering,glycoengineering
Innovative stunning technology based on a natural anesthetizing agent in ice to improve animal welfare and extend shelf-life of farmed fish (ICE2LAST)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: SME instrument
Countries involved: Spain
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

CUBI-PLAYA S.L. is a Spanish SME dedicated to ice manufacture, currently employing 39 people. We are specially targeted to the fish sector. We supply high quality ice to fisheries, aquaculture companies and fish processing factories, with the result of a close working relationship with main stakeholders. It is well known that stress situations adversely affect muscle quality, especially during the last period of fish life: slaughter. Traditional slaughtering process involves the death by asphyxia in ice or air, which exposes fish to substantial suffering over excessive periods of time. The distress suffered results in detriment of fish flesh quality and shelf-life, besides imposing avoidable suffering to fish. A pre-stunning phase is therefore recommended, to rapidly cause loss of consciousness and sensibility without pain. However, most of the slaughtering procedures used in fish farm conditions nowadays do not involve a stunning phase. In collaboration with experienced researchers, we have developed ICE2LAST, an integrated solution to speed up the stunning/sedation phase of farmed fish before slaughter, which results in a longer shelf-life and better flesh quality. Fish stunning is caused by an anesthetizing natural substance. When included into crush ice, it causes the complete stunning of the fish in less than 1 minute. By shortening the stunning process, fish flesh quality improves and its spoilage can be delayed more than 50%, compared to traditional slaughtering methods. ICE2LAST is a cost-effective and easy to handle solution, whose implementation leads to enhance fish food quality, reduce fish losses and improves animal welfare. EU is expected to increase its fish food domestic production, particularly through aquaculture promotion. With projections of a 4% annual growth in this sector, ICE2LAST can boost growth and employment in our company. Thanks to this new product we expect to employ 16 more people in Spain and overseas.

Keywords: sustainable aquaculture,animal welfare,food shelf life,food losses
Unlocking Precision Gene Therapy (UPGRADE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Italy,Italy,Italy,Italy,Belgium,France,United States
Call: Innovation platforms for advanced therapies of the future (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 14996955.0
EU funding (EUR): 14995830.0
Participants: 12
Project status: SIGNED

Gene therapy has recently shown remarkable potential to offer definitive treatments for otherwise incurable diseases. Currently, seven gene therapy products have reached the market and many more are entering clinical testing for selected indications. Moreover, emerging technologies for targeted gene editing are complementing the scope of conventional gene transfer, opening the way to precise gene correction and making possible to silence, activate or recode any sequence of interest in the genome. However, in order to realize the full potential of these strategies and broaden application of gene therapy, the field has to solve several major hurdles, including: risk of insertional mutagenesis by gene transfer vectors, limited efficiency and durability of some gene correction strategies, off target effects of editing tools, poor tissue targeting and immune response to editing components and delivery vehicles. UPGRADE will offer radical new solutions to overcome these hurdles. We will exploit and further develop disruptive new technologies for precision gene and epigenome editing and for site-specific transgene insertion, and stringently characterize their specificity and cellular responses. We will combine these improved technologies with advanced viral and non-viral vectors enabling cell/tissue targeting and immune evasion, to generate prototypes of advanced medicinal products (AMP). The safety and efficacy profile of each AMP will be stringently validated in tissues (hematopoiesis, heart and skeletal muscle, liver, retina) and disease models (muscle wasting, storage and blood disorders, hypercholesterolemia) paradigmatic for unmet medical need and potential long-term cure, if the limitations of current gene therapy strategies are overcome. These AMPs represent versatile products portable to the treatment of several other diseases because of related pathogenesis or correction strategies, thus providing the basis for tackling diseases affecting large patient groups.

Keywords: precision gene therapy,targeted gene,epigenome editing,viral and non viral vectors,advanced medicinal products,hematopoietic stem cells,muscle wasting,retinal degeneration,liver diseases
Localization and Ordering Phenomena in Statistical Physics, Probability Theory and Combinatorics (LocalOrder)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Israel
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-01-01
End date: 2021-12-31
Duration (months): 72.0
Total project cost (EUR): 1136904.0
EU funding (EUR): 1136904.0
Participants: 1
Project status: CLOSED

Mathematical statistical physics has seen spectacular progress in recent years. Existing problems which were previously unattainable were solved, opening a way to approach some of the classical open questions in the field. The proposed research focuses on phenomena of localization and long-range order in physical systems of large size, identifying several fundamental questions lying at the interface of Statistical Physics, Probability Theory and Combinatorics. One circle of questions concerns the fluctuation behavior of random surfaces, where the PI has recently proved delocalization in two dimensions answering a 1975 question of Brascamp, Lieb and Lebowitz. A main goal of the research is to establish some of the long-standing universality conjectures for random surfaces. This study is also tied to the localization features of random operators, such as random Schrodinger operators and band matrices, as well as those of reinforced random walks. The PI intends to develop this connection further to bring the state-of-the-art to the conjectured thresholds. A second circle of questions regards long-range order in high-dimensional systems. This phenomenon is predicted to encompass many models of statistical physics but rigorous results are quite limited. A notable example is the PI’s proof of Kotecky’s 1985 conjecture on the rigidity of proper 3-colorings in high dimensions. The methods used in this context are not limited to high dimensions and were recently used by the PI to prove the analogue for the loop O(n) model of Polyakov’s 1975 prediction that the 2D Heisenberg model and its higher spin versions exhibit exponential decay of correlations at any temperature. Lastly, statistical physics methods are proposed for solving purely combinatorial problems. The PI has applied this approach successfully to solve questions of existence and asymptotics for combinatorial structures and intends to develop it further to answer some of the tantalizing open questions in the field.

Keywords: random surfaces,effective interface models,random operators,reinforced random walks,localization,long range order,rigidity in high dimensions,proper colorings,hard core model,o n model
The implementation of Digital Mobile Mental Health in clinical care pathways: Towards person-centered care in psychiatry (IMMERSE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Germany,Slovakia,Slovakia,Belgium,United Kingdom
Call: Implementation research for scaling up and transfer of innovative solutions involving digital tools for people-centred care (H2020-SC1-2020-Two-Stage-RTD, 2020)
Start date: 2021-04-01
End date: 2025-03-31
Duration (months): 48.0
Total project cost (EUR): 3992016.25
EU funding (EUR): 3992016.25
Participants: 10
Project status: SIGNED

The overarching aim of IMMERSE (Implementing Mobile MEntal health Recording Strategy for Europe) is to advance the transformation of mental health care in Europe intro true person-centered care, focused on the needs of each individual seeking help for mental health problems, while giving them an active role in their treatment process and decision-making. In order to do so, IMMERSE has identified the Experience Sampling Methodology (ESM), a structured diary technique, as the methodology that puts the service user at the heart of their treatment. IMMERSE will integrate 20 years of research evidence on ESM into an innovative, clinical digital health tool, Digital Mobile Mental Health (DMMH), in close collaboration with stakeholders and extending it with mobile sensing data and innovative machine learning models. DMMH consists of an ESM app, assessing self-reports of mental state in daily life, a data-platform that allows the analysis of these data, and dashboard for visualization and feedback. IMMERSE will thoroughly evaluate strategies, processes and outcomes of DMMH implementation at 8 sites in 4 countries in Europe representing different contexts for implementation evaluation. At the same time, IMMERSE will identify and overcome key barriers and strengthen facilitators for implementation, transfer and scale-up of DMMH to routine mental health clinical practice by closely collaborating with relevant stakeholders, aligning the innovative DMMH tool to their needs. Similarly, the diverse ethical, legal and policy challenges and requirements will be identified and DMMH will be developed and implemented accordingly. Finally, IMMERSE is set out to do a cost-benefit analysis of the implementation and present a framework for future implementation of DMMH, including forecasting scenarios, aiming at a further scale-up of DMMH across 4 countries in Europe and beyond. IMMERSE thus offers a unique potential to significantly innovate mental health care in Europe.

Keywords: digital mobile mental health,person centered,implementation science,personalized psychiatry,daily life,participatory science,experience sampling methodology,digital medicine,mental health
New practices of Grassroots Innovation for Demand Driven Businesses (GIDDB)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain,Italy,Hungary
Call: peer learning of innovation agencies (H2020-INNOSUP-2014-5, 2014)
Start date: 2016-02-01
End date: 2016-10-31
Duration (months): 9.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

The present proposal regards the design of new models of intervention aimed at supporting bottom-up innovations and competiveness in SMEs founded by the young through the growth of entrepreneurial/managerial skills of young innovators, the improvement of networking opportunities for start-uppers and the development of grassroots innovations. Often, fledgling businesses are at risk of failure, and the enthusiasm of young entrepreneurs can fade out if not supported by significant business skill developments and proper partnerships. Where traditional approaches of empowering innovation in start-up businesses do not seem to work, public policies should be capable of applying less conventional methods of interventions: to drive new business models within the sharing and collaborative economy and by recognizing a central role to young innovators as part of active business communities. The objective of the project is therefore to develop a ready-to-implement policy for regional and national agencies working on innovation programmes focused on establishing a positive eco-system for start-ups created and developed by young entrepreneurs, as well as for young innovators to develop applied skills by collaborating with companies.

Keywords: young entrepreneurs,smes
Holographic acoustic assembly and manipulation (HOLOMAN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany,Germany,Germany
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-02-01
End date: 2025-07-31
Duration (months): 78.0
Total project cost (EUR): 2420125.0
EU funding (EUR): 1432625.0
Participants: 3
Project status: SIGNED

Acoustic waves exert forces when they interact with matter. Sound, and in particular ultrasound, which has a wavelength of a few hundred microns in water, is a benign and versatile tool, that has been successfully used to manipulate, trap and levitate microparticles and cells. The acoustic contrast between the material and the medium, and the spatial variation of the ultrasound field determine the interaction. Resonators and arrays of a few hundred transducers have thus far been used to generate the sound fields, but the former only yields highly symmetrical pressure patterns, and the latter cannot be scaled to achieve complex fields. Our radically new approach uses a finely contoured 3D printed acoustic hologram to generate pressure fields with orders of magnitude higher complexity than what has been possible to date. The acoustic hologram technology is a route towards truly sophisticated and 3D sound fields. This project will research the necessary computational and experimental tools to generate designed 3D ultrasound fields. We will investigate ways to use acoustic holograms for rapid manufacturing, the controlled manipulation of microrobots, and the assembly of cells. The 3D pressure fields promise the assembly and fabrication of an entire 3D object in “one shot”, something that has not been realized to date. We will also study the formation of 3D cellular assemblies, and more realistic 3D tumour models. This project will develop the technology, materials, processes, and understanding needed for the generation and use of sophisticated 3D ultrasound fields, which opens up entirely new possibilities in physical acoustics and the manipulation of matter with sound.

Keywords: holography,directed assembly,rapid 3d fabrication,cells
A unique radar sensor system to monitor movement and vital signs for elderly people in care homes (RayVS1)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Currently, Europe has the greatest percentage of population aged 65 or over (20%). As life expectancy is increasing there is an increasing prevalence of chronic diseases which represents a major challenge for health systems. In fact, total ageing costs in the EU are projected to reach 28.3% of GDP in 2060. Therefore, there is a huge need of developing innovative and minimally invasive devices for monitoring elderly vital signs parameters and movements in care homes. The golden standard methods are represented by smart sensors and camera systems. However, they lack in real-time alerting services, they need constant physical interaction and have limited measurements capabilities. Raytelligence introduces the RayVS1, a single radar sensor that can detect position, movement (fall detection), heart and respiration rate of persons in care homes without the need of physically interact with the user. The sensor provides real-time and customized alerts to caregivers, medical professionals and family members whenever the signals overcome predefined thresholds, through a dedicated cloud application. This will ensure wide coverage (multiple people monitored with one sensor) and injury prevention thus saving related healthcare costs. Moreover, it guarantees privacy to the users since personal data are securely stored into the cloud and it ensures high precision and accurate motion measurements (20μm). RayVS1 has already obtained the CE mark for in-home use. During the feasibility assessment, a go-to-market strategy and a supply chain will be established, as well as further development plan will be drafted. During the second phase of innovation project, Raytelligence will optimize the signal processing activity to monitor multiple individuals with one RayVS1 and extract another vital parameter, such as the sleep quality. The production capacity will be increase up to 15k pieces per year. Validation trials will then be initiated for obtaining CE mark as a medical device.

Keywords: real time monitoring system,non intrusive radar sensor,vital signs extraction,fall detection,alerting system,ageing,caregiving
Site-selective protein-modification chemistries for antibody-drug conjugates (ADCs) (SIMICA)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Austria,Netherlands,Netherlands,United Kingdom,Portugal
Call: Twinning (H2020-WIDESPREAD-2018-03, 2018)
Start date: 2019-10-01
End date: 2023-03-31
Duration (months): 42.0
Total project cost (EUR): 800000.0
EU funding (EUR): 800000.0
Participants: 5
Project status: SIGNED

SIMICA will provide IMM with the opportunity to integrate the European circle of research excellence institutions by cementing a sustainable science, technology and innovation network with internationally-leading organisations in the field of protein drug-conjugates. The strategy of SIMICA is based on science- and innovation-driven clustering, and is focused on the exciting and upcoming area of designing and constructing the next generation of chemically-defined and innovative protein drug-conjugates for the targeted treatment of serious conditions such as cancer. The project will allow: i) strengthening the science and technology capacity of IMM and ii) leverage its research excellence and value creation through innovation with a beneficial and quantifiable impact for the entire research and development community at IMM, the Lisbon region and Portugal. The successful implementation of this strategy will rely on specific actions, including: 1) cementing of existing and the creation of new scientific, innovative and technical collaborations through short-term staff exchanges and short-term on-site training activities; 2) training, mentoring and international exposure of IMM’s young researchers and students; 3) building an innovation ecosystem centred at IMM; 4) igniting the entrepreneurial spirit among IMM’s research community; 5) increasing science awareness among the general public through targeted dissemination and communication activities; and 6) developing a sustainability strategy to sustain the cemented network beyond project terminus. Through the completion of these activities, IMM, supported by its twinning partners, is in the best temporal and spatial position to achieve an improved capability to compete for internationally competitive research funding and to access business stakeholders. By claiming its position in research and innovation networks IMM will effectively contribute to research excellence and value creation in health at European level.

Keywords: nanoparticles,antibody drug conjugates