Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ocean Night: helping society understand the importance of the marine ecosystem (OCEAN NIGHT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Spain
Call: European Researchers' Night 2022-2023 (HORIZON-MSCA-2022-CITIZENS-01, 2022)
Start date: 2022-05-01
End date: 2024-04-30
Duration (months): 24.0
Total project cost (EUR): 299602.0
EU funding (EUR): 299602.0
Participants: 1
Project status: CLOSED

Life started in the oceans. Oceans cover the majority of Earth's surface and are the single largest ecosystem on the planet. Billions of humans live in coastal areas and depend on the functioning of this ecosystem to live. Unfortunately, human activities are seriously endangering the health of the marine ecosystem. It is therefore critical to raise awareness of the richness of this ecosystem, its importance, the challenges it faces and what we, as citizens of the world, can do to improve and preserve it through our personal choices. With the MCSA Researchers Night proposal Ocean Night we aim to contribute to this challenge by raising marine science literacy across the general population and promoting the appreciation of the importance of the marine ecosystem. Our proposal brings together all public Research Institutes across Spain working on marine science for a comprehensive 2-years outreach program. We will leverage the substantial outreach experience of the Institutes to deliver a diverse and coherent program of events aimed at engaging a geographically wide and socially diverse set of regions within Spain.

Keywords: marine science ecology science education conservation interdisciplinary science
MUlti-Sensor Inferred Trajectories (MUSIT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece,Italy,Netherlands,United States,Canada,France
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 751771.43
EU funding (EUR): 694600.0
Participants: 10
Project status: SIGNED

The abundance of tracking sensors in recent years has led to the generation of high-frequency and high-volume streams of data, including vessels, vehicles' tracking data, smartwatches, cameras, and earth observation sensors. However, there are cases where the trajectory of a moving object has gaps, errors, or is unavailable. However, a vast pool of tracking data is available but remains unexplored or underutilized and has the potential to reveal important information. The MUlti-Sensor Inferred Trajectories (MUSIT) project aims at exploring and fusing data from all heterogeneous sources to provide detailed information about a moving object’s whereabouts and behavior, reduce gaps, and produce a refined and inferred trajectory with minimal errors. The fusion of multi-sensor data is required to fill in the trajectory gaps of moving objects and attach useful semantics to the trajectory and its components. AI algorithms and spatio-temporal methodologies that can fuse information and infer the “missing knowledge” are crucial to the implementation of MUSIT. Furthermore, different representation models from multiple domains within the ICT sector will also be explored. Datasets will be made available in cases where it was previously thought impossible, and infer knowledge thus improving the overall surveillance. Therefore, the MUSIT project will tackle the aforementioned issues in a process that can be categorized into three parts: i) data collection and creation, ii) exploitation and utilization of cross-domain representation models within the ICT sector for trajectories, and iii) analysis and processing of outcomes to produce information-rich results related to vessel monitoring and urban mobility.

Keywords: spatio temporal analysis,information fusion,trajectory inference,trajectory mining,surveillance,artificial intelligence
Additive Micromanufacturing: Multimetal Multiphase Functional Architectures (AMMicro)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 1498356.0
EU funding (EUR): 1498356.0
Participants: 1
Project status: SIGNED

Current 2.5D microelectromechanical systems (MEMS) devices are disadvantaged by their distinctive unreliability. Lack of built-in damage sensing, impact protection mechanisms and the absence of application-relevant reliability tests, collectively mask the true potential of MEMS devices. AMMicro will address these limitations by designing and developing the building blocks essential for robust next-generation 3D MEMS devices. This will be done using a novel combination of cutting edge electrodeposition technique and advanced reliability testing protocols. Localized electrodeposition in liquid (LEL) is an advanced micromanufacturing technology, capable of printing 3D metal micro-/nano-architectures. With recent developments in advanced reliability testing using micro/nanomechanical testing (MNT) platforms, application-relevant high dynamic conditions are possible, yet remain under-exploited. AMMicro will break new ground by harnessing the combined potential of LEL and MNT. Multimetal microlattices will be fabricated with optimized position-specific chemical compositions to maximize specific impact energy absorption. Multiphase microlattices fabricated with dyed fluid encapsulations and pressure-release valves will enable novel self-damage sensing and impact-protection mechanisms. Full-metal 3D MEMS based load sensors will be fabricated and used for tensile testing of LEL printed nanowires. The enhanced reliability of these microarchitectures will be validated using application-relevant advanced mechanical testing. AMMicro is a highly interdisciplinary project at the boundary of materials science, mechanical, electrical and manufacturing engineering. For the material science community, it will pave the way for breakthroughs in critical applications including catalysis, phononics, photonics, etc. Beyond materials science, it has the transformative potential to revolutionize several fields including drug delivery, microscale temperature sensors, etc.
Materials International Postdoctoral Programme in Materials Science and Engineering (ATENEA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,Germany,Belgium,Australia,Liechtenstein,Poland,Switzerland,Finland,United States
Call: MSCA COFUND 2023 (HORIZON-MSCA-2023-COFUND-01, 2023)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 1194000.0
EU funding (EUR): 1194000.0
Participants: 22
Project status: SIGNED

The ATENEA programme will offer ten 30-month Postdoctoral Research (PRs) fellowships in the field of Materials Science and Engineering (MSE), a key knowledge area for many economic activities and one of the four strategic sectors of the Madrid’s Regional Research and Innovation Smart Specialization Strategy (S3) where the project will be implemented. The programme will launch one open call during its 48 months, offering high-level, interdisciplinary and intersectoral training, both in core and advanced scientific topics and transferable skills. After the programme, the fellows will be well-versed experienced researchers with highly attractive profiles for the academic and non-academic sectors, particularly for industry. IMDEA Materials Institute (IMDEA Materials) is the beneficiary and coordinator of the ATENEA programme. IMDEA Materials is acknowledged as one of Spain’s leading research institutions and received the “María de Maeztu” (MdM) unit of excellence accreditation from the Spanish Ministry of Science and Innovation. ATENEA will attract researchers worldwide through Open, Transparent, and Merit-based recruitment (OTM-R) principles. A two-step evaluation process, carried out by experienced and qualified external experts from an international, intersectoral and interdisciplinary pool, will guarantee the selection of first-class researchers. The ATENEA programme will be implemented by experienced staff in training and research support and will be governed by a consolidated management structure to guarantee its success. All supervisors have an outstanding research track record and extensive experience supervising, guiding and promoting young and more experienced researchers. Additionally, the ATENEA programme will allow PRs to improve their career prospects by carrying out intersectoral secondments within an associated partners’ network of 21 organisations.

Keywords: advanced materials,materials engineering,materials science
Probing the Finely-resolved 100 TeV Gamma-ray Sky for Ultra-heavy Dark Matter (Dark100)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 2331823.0
EU funding (EUR): 2331823.0
Participants: 1
Project status: SIGNED

Dark100 will shine a light into an underexplored dark matter particle mass range. Driven by recent theoretical developments, both in tools and motivation, Dark100 will search for dark matter particles between 100 TeV and several tens of PeV. Leveraging novel, cost-effective telescope technology, Dark100 will deploy an array of telescopes capable of probing dark matter annihilation, improving on the sensitivity of currently operating and planned gamma-ray instruments by an order of magnitude with unprecedented energy and angular resolution. Dark100 will build a unique dataset of deep gamma-ray observations of dark-matter-rich astrophysical systems. Dark matter will potentially be detected, or in the event of non-detection, limits on its velocity-weighted annihilation cross section will be set. For a non-detection, dark matter will be ruled out for part of the probed mass range and theoretical models constrained for the full probed mass range. The impact of Dark100 will be felt beyond the dark matter community. By demonstrating a new gamma-ray telescope paradigm, Dark100 will enable a range of possible astrophysical studies with gamma rays above 100 TeV, including searches for Galactic Pevatrons and transient events. Its public data archive will encourage synergy with other gamma-ray instruments. Dark100 takes advantage of a unique moment in theoretical and technological development that enables its pioneering science goals. While the theoretical motivation is fully developed and the technology is well-tested, the deployment of the Dark100 array and collection and interpretation of its observations is an ambitious project that demands the resources of an ERC consolidator grant. The PI's leadership in dark matter searches and gamma-ray analysis and simulation make her ideally suited to direct this program.

Keywords: very high energy gamma ray astronomy,cherenkov astronomy,dark matter searches with gamma rays
Unlocking cognition by Pulsatile GnRH in Alzheimer's DiseasE (UPGRADE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-10-01
End date: 2026-03-31
Duration (months): 30.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Cognitive decline associated with Alzheimer disease (AD) and other age-related dementias affects ~55 million people worldwide, and is a growing problem in aging European societies. However, most drugs fail at clinical trial, and approved treatments aimed at controlling or reversing pathological changes in the brain do not improve cognition in patients, besides having significant side effects. It is thus essential to design and test alternative approaches to enhance cognitive performance and reduce the personal, familial and societal burden of AD. There is abundant circumstantial evidence pointing to a correlation between cognitive decline or AD progression with the age-dependent loss or deregulation of gonadotropin-releasing hormone (GnRH), a neuropeptide better known for its role in the reproductive axis. Nevertheless, a link between the two processes has not been seriously considered. In a recent groundbreaking study, we have shown that AD-like cognitive deficits in Down syndrome stem from progressive GnRH loss, and restoring native GnRH in a physiologically relevant pulsatile pattern using implantable pumps safely and effectively improves cognition long after the onset of symptoms, together with augmented brain connectivity. Additionally, we have shown that tanycytes, specialized hypothalamic glial cells that control GnRH secretion, are fragmented in AD patient brains. Putting these two findings together, we hypothesize that cognitive performance in AD patients can also be enhanced by administering pulsatile GnRH at normally occurring doses, improving their quality of life,. The UPGRADE project will extend promising results we have obtained on the effectiveness of this strategy in a preclinical mouse model of AD, analyze GnRH activity and pulsatility in an existing cohort of AD patients, and finally, draft a clinical trial protocol to test the safety and efficacy of pulsatile GnRH therapy to reactivate cognitive reserves in patients with mild/moderate AD.
The right to give rights. Welfare professionals as guardians of undocumented migrants’ human rights. (GIVE RIGHTS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499837.0
EU funding (EUR): 1499837.0
Participants: 1
Project status: SIGNED

Undocumented migrants’ rights are under pressure in Europe today and migration control is increasingly deputized across different societal actors. Several decades ago, Hannah Arendt pointed out that universalistic understandings of human rights have little to offer noncitizens. Inspired by her, researchers have suggested that the foundation for undocumented migrants’ human rights instead can be found in the right-claims and contestations of migrants themselves. However, little attention has been paid to the role of welfare professionals in these processes. Across Europe, welfare professionals have resisted proposals that they should have a duty to report undocumented migrants to the police. This has been pivotal for protecting migrants’ rights. Consequently, GIVE RIGHTS will develop new conceptual tools for an interdisciplinary understanding of undocumented migrants’ rights as rooted in an interplay between migrants’ rights-claims and welfare professionals’ attitudes, practices, and collective contestations – highlighting the underexamined relational character of rights. The project investigates the politics of undocumented migrants’ rights as an interplay between different actors with converging interests: Undocumented migrants want access to their human rights – in Arendt’s words they want to have a “right to have rights” – and welfare professionals do not want to act as extended border guards but have a “right to GIVE RIGHTS”. GIVE RIGHTS will compare Italy, the Netherlands, Sweden and the UK where the protection of undocumented migrants’ access to rights are, or have recently been, undergoing intense negotiations. Through its novel theoretical framework and by innovatively combining survey data with policy mapping, qualitative media analysis, participant observation, focus groups and expert interviews, GIVE RIGHTS provides a new research agenda for theoretical and political debates on the future of human rights in Europe.

Keywords: undocumented migrants,human rights,welfare professionals,firewalls
Restoring the Immune Response in Glioblastoma by Microglial-Targeting of Autophagy Inhibitors. (MiTAI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 200400.0
EU funding (EUR): 200400.0
Participants: 1
Project status: SIGNED

Glioblastoma is a highly aggressive type of brain cancer that kills around 15,000 people per year in Europe alone. It also has a devastating effect on patients' quality of life. Therefore, the clinical need in glioblastoma management is one of the highest in oncology: effective treatments are dearly needed. Over the past decade, the brain tissue surrounding glioblastoma tumors has been intensively studied. In this so-called 'tumor microenvironment' (TME), microglial cells make up the bulk cell type. Although immune cells by nature, TME microglial cells are reprogrammed to take on a tumor-supporting role: they become immunosuppressive and start secreting growth factors and nutrients that fuel tumor proliferation. Autophagy, best known as a cellular recycling pathway, is a masterswitch that determines the immune status in microglial and other immune cells. It also supports the process of nutrient secretion in TME microglia. Therefore, inhibition of microglial autophagy can be a viable strategy to restore the immune response against glioblastoma tumors. Strong preclinical evidence in favor of this approach is available. However, translation into a new glioblastoma therapy is difficult, because the presence of autophagy inhibitors in the brain could also be dangerous to neurons. In response, this proposal wants to deliver and investigate autophagy inhibitors that selectively target brain microglial cells. A vectorizing approach is proposed for ULK1/2 inhibitors and PROTACS, which are very potent autophagy inhibitors. The proposal will thorougly investigate the compounds in vitro and in cellulo. For selected, highly promising molecules, in vivo proof of concept will be sought in a murine, orthotopic glioblastoma model. Next to obtaining selective and effective microglial autophagy inhibitors, the design of metabolically stable compounds with sufficient bioavailability in brain can be expected to be additional, prime challenges of the project.

Keywords: glioblastoma,autophagy,ulk1 2,microglial targeting
Exact and Approximate Computation of Tensors and Polynomials (EACTP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 2335000.0
EU funding (EUR): 2335000.0
Participants: 1
Project status: SIGNED

This research proposal will address fundamental problems concerning the complexity of computing and manipulating polynomials. For example, consider the following questions: 1. What is the complexity of computing the total weight of perfect matchings of a weighted graph? 2. Is there an efficient deterministic parallel algorithm that determines whether a graph has a perfect matching? 3. Is approximation much easier than exact computation? 4. How many EPR pairs can we distill from a given quantum state? These seemingly unrelated questions represent some of the most important and challenging open problems in theoretical computer science: the first is the algebraic analog of the famous P vs. NP problem. The second question amounts to asking whether a symbolic matrix associated with the graph has full rank. Parallel randomized algorithms for computing this rank are known, but not deterministic ones. This is an instance of the polynomial identity testing (PIT) problem, the most fundamental algebraic derandomization problem. The third question asks about the relation between a complexity class and its closure, which lies at the heart of the Geometric Complexity Theory (GCT) program. The last question concerns the subrank of a tensor representing the given quantum state. Problems related to rank of tensors are at the heart of both algebraic complexity and quantum information theory. Recent years have seen tremendous advance in our understanding of algebraic computations with new lower bounds, new PIT algorithms and with increasing connections to other branches of computer science and mathematics discovered. Results proved by the PI play an important role in all of these advances. This project aims to study these and related problems and to develop new methods for solving them. Making progress on any of these problems will constitute a significant breakthrough.

Keywords: algebraic complexity,polynomials,tensors,arithmetic circuits,quantum entanglement,gct,vp,vnp,algebraic branching programs,complexity,sparse polynomials