Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Control of disease tolerance to infection by Biliverdin Reductase A (BILITOLERANCE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-12-01
End date: 2021-07-20
Duration (months): 24.0
Total project cost (EUR): 160635.6
EU funding (EUR): 160635.6
Participants: 1
Project status: CLOSED

The immune system was shaped through evolution, primarily through the selective pressure imposed by pathogens. This led to the emergence of multiple mechanisms that limit the negative impact of pathogens on host health and fitness. The best recognized defense strategy against infections relies on resistance mechanisms that aim at pathogen containment, expulsion or clearance. While crucial for host survival to infection, resistance mechanisms can carry significant trade-offs, often driven by oxidative stress and damage imposed to host parenchyma cells, and in some cases compromising the functional output of host tissues, i.e. immunopathology. Presumably for this reason, resistance mechanisms are coupled to countervailing oxidative stress responses that preserve parenchyma tissue function. These provide tissue damage control without exerting a direct negative impact on pathogens and as such are said to confer disease tolerance to infection. This defense strategy relies on the expression of a number of evolutionary conserved effector genes controlling the pro-oxidant effects of iron and heme, as illustrated for the heme catabolizing enzyme heme oxygenase 1 or the iron sequestering protein ferritin H chain. BILITOLERANCE aims at identifying and characterizing an unexplored and possibly central component of this tissue damage control mechanism that relies on the conversion of the end-product of heme catabolism biliverdin into bilirubin, by biliverdin reductase A (BVRA). The central hypothesis to be tested by BILITOLERANCE is that bilirubin generated by BVRA provides a potent lipophilic anti-oxidant defense mechanism that limits the deleterious effects of lipid peroxidation. Moreover BILITOLERANCE will test the hypothesis that bilirubin also signals via the aryl hydrocarbon receptor (AhR) to modulate the activation of tissue-resident macrophages and promote tissue damage control and disease tolerance to infection.

Keywords: disease tolerance,oxidative stress,biliverdin reductase,bilirubin,infection biology
MOdular Spacecraft Assembly and Reconfiguration (MOSAR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling advances in space technology
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Belgium,France,France,United Kingdom,United Kingdom
Call: SRC – Space robotics technologies (H2020-SPACE-2018, 2018)
Start date: 2019-03-01
End date: 2021-06-30
Duration (months): 28.0
Total project cost (EUR): 3999962.49
EU funding (EUR): 3999962.49
Participants: 9
Project status: CLOSED

Since commercial exploitation of satellites was endeavored more than 50 years ago (Telstar 1 in 1962), commercial use of space became a huge and very much strategic market, reaching ~50 billion of USD in 2004, and in the range of 256 billion of USD in 2013 (OECD global estimates, 2014). Fierce competition is to be expected in the worldwide space industry to obtain major shares of the key commercial space segments. Offering cost effective, performant, reliable, scalable and flexible solutions will be essential to make the European space industry spearheading strategic segments of the commercial space. The development of novel, European technologies that would allow standardizing satellites components, facilitating their assembly, reducing time between customer’s orders and commissioning in space, repairing and upgrading components directly in orbit instead of replacing entirely a deprecated or damaged satellite, would provide extremely valuable competitive assets to establish European leadership in a number of key commercial space segments. Leveraging the outcomes of the Space Robotics Technologies SRC building blocks (from Call 1 / OG1,2,3,4,5), this proposal (MOSAR) aims to develop, integrate and demonstrate such technologies required to enable a fundamental shift of paradigm with satellites (and more widely spacecrafts) manufacturing and commercial space exploitation. As a key driver, MOSAR intends to leverage know-how and standards already available in the European space industry for satellites (small / nano sats in particular), to facilitate the uptake of project results by future customers. Key representatives of that industry are part of the consortium.

Keywords: modular robotics
Development of A Method for Analysis of Creep Behaviour of Welded Rotating Components of High Temperature Applications Based on Eigenstrain Theory (RESTREIG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-19
End date: 2020-06-18
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The need for high-quality joints in the aerospace industry has fostered the use of inertia friction welding for nickel-based super-alloy components. This technique provides improvements in the joint quality when compared to the fusion welding techniques, but understanding on the effect of residual stress on creep deformation of welded components is limited. The proposed research aims to develop new computational and numerical tools to reproduce the residual stress field in inertia welded components in the as-welded and post-weld heat treated conditions. This innovative approach will meet experimental data with the eigenstrain theory to reconstruct stress fields in large scales and provide a realistic model to understand creep behavior of materials under complex loading and high-temperature conditions. To achieve this target, the eigenstrain theory will be used with experimental measurements. This will allow modeling of complex geometries with high accuracy. The study will be composed of three stages which are data collection for eigenstrain reconstruction method, creating a model for eigenstrain reconstruction process and development of a visco-plastic model for investigating creep behavior of post weld heat treated samples. Results and data created in the first two stages will be used to create the visco-plastic model. Experiments will be performed using diffraction and contour methods and numerical models will be created using ABAQUS commercial finite element software. All research, management, training, dissemination, public engagement, and communication activities are scheduled into a 2 years work plan. The developed methodology is expected to provide a better understanding of creep behavior, to be used by other researcher and be beneficial for industry on the development of components with lower cost and longer service life. The success of this research will have a positive impact on the European Union and United Kingdom economies and societies.
Suffering America: Writing Pain in Nineteenth-Century United States Literature (USPAIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The project entitled “Suffering America: Writing Pain in Nineteenth-Century United States Literature” (USPAIN) aims to analyze the experience of physical pain and psychological suffering as it is represented in American literary texts across the nineteenth-century. Although pain and suffering are often reputed to be inexpressible through language, as Virginia Woolf and others in her wake argued, this project will show how literary writing offers a discursive space for their articulation and for their inscription as cultural and historical sensations and affects. Using close readings of works by Ralph Waldo Emerson, Herman Melville, Emily Dickinson, Henry and Alice James among others, Dr. Constantinesco will study various forms of pain and suffering, from labor injuries and war wounds to nervous disorders, feminine hysteria, psychological trauma, and grief, with a view to uncover how American literature engaged with the nation’s changing culture of pain in the 19th century. Between 1830 and the turn of the 20th century, the inaugural promise of an unalienable right to the pursuit of happiness quickly receded in the face of the suffering of black slaves and of the violent extermination of Indian populations, and the United States emerged from the Civil War as a “republic of suffering” whose agonies extended well beyond the end of Reconstruction. The social meaning of pain similarly transformed, as Christian narratives of redemption through suffering gave way to a more modern sensibility grounded in the avoidance of pain and strengthened by medical progress and legal advances, such as the invention of general anesthesia or tort law jurisprudence, even as sympathy continued to function as a privileged mode of national affiliation. Dr. Constantinesco will demonstrate how 19th-century American literature simultaneously reflects and unsettles these developments to configure pain as a critical locus where individual and collective identifications coalesce and come apart.

Keywords: american literature,medical humanities
Co-Create Change in Research Funding and Performing (Co-Change)

Framework: Horizon 2020 — Science with and for Society
Programme: Develop the governance for the advancement of responsible research and innovation by all stakeholders, which is sensitive to society needs and demands and promote an ethics framework for research and innovation
Action type: Coordination and support actions
Countries involved: Austria,Spain,Serbia,Finland,Finland,Hungary,Netherlands
Call: Grounding RRI practices in research and innovation funding and performing organisations (H2020-SwafS-2019-1, 2019)
Start date: 2020-02-01
End date: 2023-04-30
Duration (months): 39.0
Total project cost (EUR): 1498833.75
EU funding (EUR): 1498833.75
Participants: 10
Project status: SIGNED

Co-Change strengthens transformative capacity and leadership for RRI through an innovative systemic approach, centred on the concept of change labs, building on years of solid experience. The project activates change coalitions around each lab, paying particular attention to interactions and dependencies of actors in each R&I ecosystem, since research performing (RPOs) and research funding (RFOs) organisations co-evolve in and with the R&I ecosystems they are embedded in. This embeddedness forms the social and institutional context, which either supports or slows down changes in the system. By implementing change labs in their ecosystems, we generate transformative capacity for institutional change in terms of practices, procedures, rules and norms at the individual, organisational and system levels. Co-Change supports the implementation of institutional changes of R&I actors within and beyond the key areas of RRI. Our consortium members of RPOs and RFOs across Europe act as change agents. We set out to establish change labs as instruments for promoting and sustaining institutional change within our own organisations and reach out to actors in our innovation ecosystems. As well as co-creating RRI practices in our own organisations, we also do so in organisations that have signalled their interest. Since these include partners from research performing, financing and governance institutions, we can build change coalitions at national and EU scale. The outcomes of all change labs will be analysed to produce a toolbox and field book for RRI related institutional changes which will be broadly disseminated by committed multipliers. To widen our impact, we publish a call for innovative RRI practices, inviting more European organizations to Co-Change activities. Our project also features a sounding board with experienced RRI project coordinators, helping communicate with other projects in the field, and an advisory board with quadruple helix partners for further reach.

Keywords: institutional changes,transformative capacity,innovation ecosystems
High-Tech development of game-changing innovation for food waste reduction (Food waste reduction)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Denmark
Call: European SME innovation Associate - pilot (H2020-INNOSUP-2020-02, 2020)
Start date: 2020-09-16
End date: 2021-09-15
Duration (months): 12.0
Total project cost (EUR): 205364.29
EU funding (EUR): 143755.0
Participants: 1
Project status: CLOSED

20% of all meat and 35% of all fish produced is wasted. In Europe 5 mio tons of perfectly good meat and fish is wasted due to incorrect freshness evaluations and shelf-life estimations set by the industry. This corresponds to 17 bil € and 85 mio tons of CO2. Currently shelf-life is estimated from human senses or rule of tomb, but AmiNIC is developing a handheld user-friendly device that within seconds measures freshness and predicts correct and precise expiration dates for meat and fish. The device measures the concentration of freshness indicative volatiles and correlate the level of these with values in a pre-obtained database, containing prediction-curves, that will enable meat and fish handlings SMEs to easily predict correct expiration dates. The effect of correct and precise expiration dates will transmit down the value chain and prevent large amounts of these high-value and highly unsustainable products from being wasted. Quantitative and reliable assessment methods are in high demand, but development of such a game-changing technology requires highly-skilled employees, which, for SMEs, is hard to acquire. For AmiNIC, competences and expertise within in nano-sensing technologies is needed and this is only feasible with the means to employ suitable candidates within this field. This candidate will be trained in areas relevant to the development which will lead to fabrication of a novel and substantially improved sensing device and validation of this against current expiration date evaluation methods: human sensory analysis. AmiNIC is, and has been, collaborating closely with Universities and RTOs on the development and validation of this Key Enabling Technology, but competences and knowledge within nanosized semiconductor sensing units is necessary. The very topic-specific skills we need are not available on the national level and we will have to be acquired them from elsewhere in order for us to bringing this truly innovative product to the market by 2021.

Keywords: nanotechnology,key enabling technology,sensor for food waste reduction
creTRAP for in situ Characterization of Fibrosis-Promoting Pathways in Non-alcoholic Fatty Liver Disease (InCisive)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

The aim of the proposed project is to develop and employ novel tools to identify and target fibrosis-promoting, molecular pathways in non-alcoholic fatty liver disease. Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. Affecting 20-30% of the Western population, NAFLD is now the most common liver disease. Yet, the lack of tools for studying the initiation and progression of NAFLD at the cellular level limits our ability to develop novel strategies for rational, therapeutic intervention. This proposal details a cross-disciplinary research project aimed at addressing this challenge while facilitating the transfer of knowledge and new technologies to the Danish biomedical research community. Over the course of the proposed project, the aim will be pursued through fulfilment of these specific objectives: (A) Development of novel biochemical tools for in situ gene expression profiling and gene knock-down in select cell types. (B) Implementation of these tools to discover intra- and intercellular mechanisms linking metabolic stress to chronic liver disease in mouse models of diet-induced fibrosis. (C) Cross-disciplinary, experimental validation of hypotheses generated from bioinformatic integration of gene expression profiles from individual cell populations and experimental treatment of NAFLD in animal models. (D) Communication of discoveries and their relevance through external seminars and through scientific, popular, and social media platforms. Through research and training activities at the University of Southern Denmark, development of collaborations with researchers at partnering institutions, and dissemination of results to the broader European community, the proposed project serves as foundation for my independent career in European biomedical research. Concurrently, the proposed project has the potential to greatly improve our understanding of chronic liver disease and devise novel treatment strategies.

Keywords: fibrosis,ribosomal profiling
‘This country is ours’: Collective psychological OWNERShip and ethnic attitudes (OWNERS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2023-05-31
Duration (months): 74.0
Total project cost (EUR): 1499082.0
EU funding (EUR): 1499082.0
Participants: 1
Project status: SIGNED

Even in the absence of legal ownership, people tend to experience objects, places, and ideas as belonging to them (‘mine’). This state of mind is called psychological ownership. Research has shown that experiences of ownership are very important for individuals, but can also lead to interpersonal conflicts. What we know almost nothing about is collective psychological ownership (CPO): a shared sense that something is ‘ours’. CPO might be especially relevant with regard to territories and in the context of intergroup relations. Statements like ‘we were here first’ or ‘we built this country’ are increasingly used by right-wing politicians in immigration countries to claim ownership on historical basis for the dominant ethnic group, and to exclude newcomers. There are also contexts where two established groups disagree about territorial ownership, such as Albanians and Serbs in Kosovo. While CPO might strengthen solidarity within groups, it might worsen intergroup relations, thus threatening social cohesion. It is important to establish where a sense of CPO comes from, and how it shapes intergroup relations, so that interventions could be implemented. This ground-breaking project examines 1) the extent to which people perceive their ethnic group as historically owning the country, 2) the psychological needs that motivate them to claim collective ownership, and 3) the implications of collective ownership claims for attitudes towards ethnic groups. My approach is multidisciplinary, combining social psychological theories on intergroup relations with the literature on ownership and territoriality from organizational science and anthropology. I will develop an instrument to measure CPO and provide first empirical evidence about the importance of CPO by collecting representative survey data in European immigration countries (Netherlands, UK, France), settler societies (Australia, New Zealand, USA), and countries with clear territorial disputes (Kosovo, Cyprus, Israel).

Keywords: group identities,ethnic attitudes,psychological ownership,immigrants,minority rights
African Swine Fever, the Sus scrofa evolutionary genomic response (ASF_SwineResistance)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

African Swine Fever is a notifiable devastating hemorrhagic fever with high mortality rates in pigs. It affects all members of the Suidae family and is one of the most important pig diseases due to its severe socio-economic consequences for affected countries, the difficulty of preventing spread across country boundaries, and the lack of vaccine and therapeutic control measures. We will use genome-wide DNA technologies to understand the Sus scrofa genomic response to the infection. Specifically, we will compare data on both healthy and infected individuals to (1) identify the possible presence of regions under selection. We will also assess (2) the hybridization rate and (3) the interaction strategies between the domestic pig and the wild boar to (4) identify the possible transmission routes in pig diseases.

Keywords: sus scrofa,african swine fever,hybridization,selection