Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of a complete low cost Card Payment Acceptance Infrastructure (uCube2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: France
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Payment Industry is an industry under transformation. The mobile point-of-sale (mPOS) started a revolution in payment acceptance and has opened a whole new market segment of micro-merchants bringing a low-cost POS solution allowing them to accept card transactions cheaply and easily. The mPOS model is forecast to grow rapidly reaching 3 million users by 2017 in Europe. Global market is projected to have 54 million installed units by 2019. uCube2 project is carried out by the SME Youtransactor (2014 TO : 9M€, Headcount : 35), a company with proven expertise on professional mobility, electronic payment, security and e-ID, developing innovative products for payment acceptance. The objective of YouTransactor in this project is to propose a disruptive innovation in front of the mPOS model and traditional EFTPOS networks for all size retailer market segment. This innovation called the uCube2 aims to find the sweet spot between mPOS and EFTPOS business model. It consists in developing an all-in-one low cost POS solution based on an innovative card payment acceptance device and a global acceptance Infrastructure based on Cloud technologies. YouTransactor mainly targets two stakeholders: First, Merchant Banks which are arriving late to the mPOS market and need to move quickly. Then, selected merchant segment directly. Preliminary work on uCube2 led to the success in implementing the global acceptance Infrastructure between merchants and Acquiring Banks. The present feasibility study aims at - The finalization of the specifications thanks to the involvement of 2-3 acquirers, - The elaboration of a detailed business plan based on operational experience and acquiring banks interviews: validation of Youtransactor business model, value proposition, market segment targets, - The freedom to operate. Youtransactor expects to apply for at least two patents Later on, Phase 2 would perfectly allow to finance further development plan on the final uCube2 solution.

Keywords: eftpos,freedom to operate,secure integrated chip lte,payment acceptance infrastructure,acquirer
Geometric and Harmonic Analysis with Interdisciplinary Applications (GHAIA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Spain,Spain,Australia,Argentina,Italy,Taiwan, Province of China,France,France,United States,Canada
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2017-11-01
End date: 2023-09-30
Duration (months): 71.0
Total project cost (EUR): 1930500.0
EU funding (EUR): 1782000.0
Participants: 29
Project status: SIGNED

GHAIA will promote excellence through mobility to the world leader Universities in pure and applied mathematical research: Princeton University, Mit, Yale, Johns Hopkins, the Universities of California, of Texas, of Houston, of Pittsburgh, the Washington University (St. Louis), and the Worchester Polytechnical Institute, the Academia Sinica, the University of Buenos Aires have joined the consortium. European researchers will have the extraordinary opportunity to work in their exciting environment as well as receiving visiting researchers from south America. Moreover two selected enterprises have joined the consortium, allowing intersectorial mobility: Marposs and GMV, leaders in the strategic sectors of EU industry of precision equipments for automatic inspection, and of satellite navigation. Emerging technological problems call for the development of a new integrated framework of geometric and harmonic analysis, which unify in an original picture problems strongly influenced by symmetries and coming from different mathematical and technological fields. The exploitation of groups and supergroups invariances is one of the central goals of harmonic analysis, and nonlocal or nonlinear PDE in group setting present new and unexpected properties. Achievements in these directions are strictly related to a good geometric analysis of the ambient space. With these instruments we will be able to contribute to some of the biggest challenges of this century: data analysis and models of brain functionality. The final goal will be to obtain new geometrical instruments of machine vision, to be applied to develop new products for measurement of industrial processes and for satellite guidance. The international collaborations, through research and secondments, with the extraordinary selected third countries institutions of the consortium, will provide very high level transfer of knowledge and will have a strong impact on the research capability of the EU sending institutions.

Keywords: harmonic analysis,nonlocal pde,minimal surfaces,geometric models of the visual cortex,applications to satellite navigation and automatic inspection
Synergistic Resistive Switching of Perovskite and Silicon Carbide materials for Advanced ReRAM micro Devices (PerovSiC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-10-20
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Perovskite oxides are one of the most promising materials for developing new ReRAM devices, because they show a Resistive Switching (RS) behaviour and multilevel (ML) storage properties through reversible nanoionics redox phenomena. However, several challenges remain to be addressed before introducing them in the emerging memories market. From a material point of view, it is still unclear how to tune and control the mass transport properties at the nanoscale to get the best resistive switch response. From a device point of view, the development of new heterostructures thermally and chemically stable and compatible with the microelectronics technology is required. The ‘PerovSiC’ project combines synergistically perovskite and carbide materials to overcome the current constraints. Starting from the recent breakthroughs of the hosting group, the project focuses on understanding the RS behaviour in perovskites using physical and chemical cutting-edge characterization methods. Further, computational modeling will allow improving the RS process in the new carbide-based heterostructures. The final optimized configuration will be integrated in a highly stable ML ReRAM device. The results of the project will lead to unexpected breakthroughs for neuromorphic computation, memories and logic devices. The multidisciplinary approach proposed will allow the researcher candidate gaining a deep understanding and specialisation in material science - acquiring new competences in advanced techniques, such as XPEEM and operando Raman - and in Key Enabling Technologies, such as micro-technology. Moreover, the collaboration with the ENSC-Lille and the Institute Néel will complement the researcher’s training giving her unique skills in IEDP-ToF-SIMS and synchrotron measurements. Therefore, planned research and training activities in the ‘PerovSiC’ project will re-enforce a position of professional maturity in research and will provide the researcher new career perspectives.

Keywords: resistive switching,perovskite oxides,conductive carbides,thin films,tailored engineering nanostructures,nanoscale mechanisms,advanced characterization,computational modelling,multilevel reram device
Resource efficient bio-chemical production and waste treatment (REBOOT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1494622.0
EU funding (EUR): 1494622.0
Participants: 1
Project status: SIGNED

The REBOOT project will create a disruptive wet waste valorisation technology where valuable resources are re-used rather than disposed of while tackling two urgent environmental challenges: nutrient circularity and climate change. Wastewater treatment sludge and manure treatment technologies are currently not satisfactory and there is no solution to efficiently re-use the resources it contains: phosphorous and carbon. The aim of REBOOT is to completely recover phosphorous from wastes while generating carbon neutral transportation fuels and a carbon sink in the form of carbon materials. The project will employ a frontier technology called hydrothermal liquefaction (HTL) which uses high temperature and pressure to produce a liquid product similar to petroleum termed bio-crude. This will be used for a range of innovative applications such as renewable aviation fuel, functionalized carbon materials and bio-bitumen. The possibility of complete phosphorous recovery in HTL is a completely new concept, previously thought impossible as only continuous HTL reactors can theoretically achieve this. The complex hydrothermal chemistry of salts can only be exploited on such advanced reactors that are currently beyond state-of-the-art. The specific objectives of REBOOT are: (1) mechanistic understanding of salt behaviour in multi-phase hydrothermal systems with the aim of full recovery. (2) Develop tailored strategies for in-situ jet fuel synthesis. (3) Establish microbial electrolysis cells for in-situ hydrogen production and nutrient recovery. REBOOT will be carried out on pilot continuous reactors, where the challenging physical conditions can be explored, exploited and new engineering solutions developed. If REBOOT is successful it will enable society to tackle existing waste problems while recovering nutrients and producing renewable materials, replacing fossil derived ones; representing a revolutionary solution to wet waste management in the emerging circular bio-economy.

Keywords: phosphorous,hydrothermal,liquefaction,sludge,manure,biofuel,jet fuel,circular economy
Towards identification of the unifying principles of vertebrate adaptive immunity (ImmUne)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-06-01
End date: 2024-05-31
Duration (months): 60.0
Total project cost (EUR): 2498813.0
EU funding (EUR): 2498813.0
Participants: 1
Project status: SIGNED

About 500 million years ago, the two sister groups of vertebrates independently evolved alternative forms of adaptive immunity, representing a striking example of convergent evolution. Whereas the components and functions of the immune system in jawed vertebrates (ranging from sharks to humans) are well characterized, much remains to be learned about adaptive immunity in jawless vertebrates (lampreys and hagfishes). Up to now, progress in understanding immunity in jawless fishes was hampered by their complex life-cycle, long generation time, and the difficulty of raising fish in the laboratory for extended periods, particularly after in vitro fertilization. Based on our recent methodological advances in aquatic husbandry and successful CRISPR/Cas9-mediated genetic modification, we propose to conduct a large-scale analysis of cellular immunity in lampreys laying the foundations for the identification of the unifying principles of vertebrate immunity. Our experiments will address the development and characteristics of different T cell subsets, the molecular basis of antigen receptor assembly, and the function of the two principal T cell lineages during the immune response. We will also examine the structure and function of the stromal microenvironment in the lamprey thymus equivalent, which is considered to be the site of T cell development. A particular focus will be on the functional analysis of a recently discovered MHC-like locus in the context of T cell development, and in the essential self/nonself discrimination mechanism(s) at play during the immune response. We expect that the identification of common design principles of adaptive immunity in vertebrates will provide us with an unprecedented view on immune functions in humans, potentially guiding the development of novel strategies for the treatment of failing immunity in patients with immunodeficiency and/or autoimmunity.

Keywords: thymus,t cell,lamprey,evolution
System-wide discovery and analysis of inositol pyrophosphate signaling networks in plants (INSPIRE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-06-01
End date: 2025-05-31
Duration (months): 72.0
Total project cost (EUR): 1781251.0
EU funding (EUR): 1781251.0
Participants: 1
Project status: SIGNED

Inositol pyrophosphates (PP-InsPs) are soluble signaling molecules known to play diverse roles in fungal and animal cell signaling. The metabolism of PP-InsPs in plants however is poorly understood and many signaling pathways controlled by PP-InsPs remain to be discovered. Funded by an ERC starting grant, we have previously identified protein sensor domains for PP-InsPs, which allow PP-InsPs to act as central regulators of phosphate homeostasis in all eukaryotes. Genetic disruption of PP-InsP synthesis results in dramatic phenotypes in the model plant Arabidopsis, which however cannot be rationalized by defects in phosphate signaling only. Based on these physiological observations, we generated a system-wide Arabidopsis PP-InsP interactome, using an affinity-matrix absorbed non-hydrolyzable PP-InsP analog. Surprisingly, hundreds of novel candidates from different protein families were identified in this screen, now enabling us to study PP-InsP catabolism and a multitude of PP-InsP-mediated signaling processes. Here, I propose to combine quantitative biochemistry and structural biology with cell biology and genome editing to dissect plant PP-InsP signaling networks at the physiological level and in mechanistic detail. Specifically, we will define the roles for PP-InsPs in plant light sensing and signaling, in flowering time regulation and in plant immune responses. Our ultimate goal will be to investigate the cross-talk between different PP-InsP-controlled signaling pathways and to define central signaling hubs. I envision that the work outlined in this proposal will yield a mechanistically validated system’s-level view of PP-InsP signal transduction in plants, which may allow us to better understand how plants develop and interact with their environment, and that may enable us to improve crop performance in the future.

Keywords: inositol pyrophosphate metabolism,inositol pyrophosphate signal transduction,protein kinases,phosphatases,plant light signal transduction,plant flowering time regulation,genetics in arabidopsis
AMbitious Bids: Investigating Roman Elections (78-46 BC) (AMBIRE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2024-09-30
Duration (months): 36.0
Total project cost (EUR): 257209.92
EU funding (EUR): 257209.92
Participants: 1
Project status: SIGNED

AMBIRE wants to investigate the reasons whereby Roman magistrates in Rome between 78 and 46 BC won the elections; that is, what made them successful candidates in a period of political crisis. This problematic is strictly connected to other fundamental questions in modern scholarly debate, about the actual political power of the Roman people, the existence of political programmes, or the nature of the crisis of the Republic. The modern discussion was ignited in the 1980s from a radical critique to the old conception of the Roman state as being a closed oligarchy, prompting a revision of many still unquestioned aspects of Roman political life. However, new research has focused more on processes, rather than persons. AMBIRE wants to address this gap by focusing on individuals, and integrating historical analysis with perspectives drawn from political psychology. This has a great potential for new, more complex and multifaceted perspectives on the field, and for establishing a new field of enquiry. Thus, the results of this 3-years project, disseminated through academic publications and seminars, will greatly contribute to the aforementioned debate. The mutual exchange of knowledge between my host department (especially my supervisor, an expert in the field) and me, and the collaboration with the department of Psychology at my host institution will be instrumental towards this aim. This project can also provide useful insights into modernity – studying the reasons for the success of different types of propaganda and political campaigns in a moment of crisis is very relevant to modern societal and political challenges. Thus the action includes initiatives to reach out to young people and the general public, through visits to schools, an educational video and public events.

Keywords: late roman republic,roman elections,roman magistrates
Dissecting how breast cancer-associated inflammation shapes invariant natural killer T cell activity during metastatic progression (BreaKer)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-12-21
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: SIGNED

Breast cancer is the second cause of cancer-related death in women. Although cancer immunotherapy emerged as a successful therapy for many cancer types, the response of metastatic breast cancer patients to immune checkpoint blockade remains disappointing, urging for a better understanding of the breast cancer immune landscape. iNKT cells are lipid-specific T cells that bridge innate and adaptive immunity and exert a plethora of immune functions depending on tissue distribution. Despite their known antitumor potential, they have been largely overlooked in the cancer field for their content paucity in cancer patients. I hypothesize that their scarce abundance and poor activation status is caused by cancer-induced immunosuppressive mechanisms. Indeed, I observed that circulating and metastasis-infiltrating iNKT cells are functionally impaired in the K14cre;Cdh1F/F;Trp53F/F(KEP)-based mouse model of de novo breast cancer metastases. With a translational approach, I will provide an unprecedented comprehensive dataset comparing iNKT cell immunophenotype in metastatic breast cancer patients and healthy controls. Next, I will generate human iNKT cell lines to perform in vitro mechanistic studies aimed at assessing how cancer-associated inflammation can modulate iNKT cell antitumor activity. Moreover, the innovative use of iNKT cell deficient Jα18-/- mice coupled to the KEP-based model of breast cancer metastases, will offer a clear picture of the role of iNKT cells and their cancer-associated cellular networks during the metastatic cascade. Finally, I will in vivo deplete immunosuppressive cells to unleash iNKT cell antitumor activity. My solid knowledge of iNKT cell biology combined with the expertise in breast cancer-associated inflammation of the hosting lab and the cutting-edge clinical research of the institute will uniquely generate fundamental knowledge with high applicative potential for the design of novel combinatorial immunotherapies for metastatic breast cancer.

Keywords: inkt cells,breast cancer metastasis,cancer immunosuppression,myeloid cells,breast cancer patients,genetically engineered mouse models,translational research
Variety, Veracity, VaLue: Handling the Multiplicity of Urban Sensors (VaVeL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Israel,Germany,Ireland,Germany,Poland,Greece
Call: Big data - research (H2020-ICT-2015, 2015)
Start date: 2015-12-01
End date: 2018-11-30
Duration (months): 36.0
Total project cost (EUR): 3999668.75
EU funding (EUR): 3999668.75
Participants: 10
Project status: CLOSED

Urban environments are awash with data from fixed and mobile sensors and monitoring infrastructures from public, private, or industry sources. Making such data useful would enable developing novel big data applications to benefit the citizens of Europe in areas such as transportation, infrastructures, and crime prevention. Urban data is heterogeneous, noisy, and unlabeled, which severely reduces its usability. Succinctly stated, urban data are difficult to understand. The goal of the VaVel project is to radically advance our ability to use urban data in applications that can identify and address citizen needs and improve urban life. Our motivation comes from problems in urban transportation. This project will develop a general purpose framework for managing and mining multiple heterogeneous urban data streams for cities become more efficient, productive and resilient. The framework will be able to solve major issues that arise with urban transportation related data and are currently not dealt by existing stream management technologies. The project brings together two European cities that provide diverse large scale data of cross-country origin and real application needs, three major European companies in this space, and a strong group of researchers that have uniquely strong expertise in analyzing real-life urban data. VaVel aims at making fundamental advances in addressing the most critical inefficiencies of current (big) data management and stream frameworks to cope with emerging urban sensor data thus making European urban data more accessible and easy to use and enhancing European industries that use big data management and analytics. The consortium develops end-user driven concrete scenaria that are addressing real, important problems with the potential of enormous impact, and a large spectrum of technology requirements, thus enabling the realization of the fundamental capabilities required and the realistic evaluation of the success of our methods.