Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Characterization of the circadian chromatin landscape using a novel CRISPR/Cas9-guided proximity-labelling technique (CLOCK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-12-01
End date: 2022-11-30
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

To stay in synchrony with environmental cycles, most living organisms possess endogenous clocks. Circadian clocks are molecular oscillators present in most mammalian cells that drive circadian (~24 h) rhythms of a wide range of molecular, physiological and behavioral functions. Circadian clocks are essential for health. In humans their dysregulation (e.g. caused by shift work, jet lag etc.) has been associated with the development of multiple pathologies (e.g. cancer, metabolic diseases like diabetes and obesity as well as cardiovascular and neurodegenerative diseases) prevalent in the European Union. One central aspect of molecular oscillator function is the tight regulation of circadian transcription. Over the years, several proteins and cis-regulatory enhancer elements (i.e. specific sequences located around the promoter region, e.g. E-box, RRE, D-box) have been shown to be essential for circadian transcription. However, mainly because of technical limitations, those studies focused on few regulators and have left many gaps in the understanding of the dynamics of the circadian transcription. Therefore, this project proposes to use state-of-the-art quantitative genomic-locus proteomics to provide the first comprehensive and unbiased characterization of the rhythmic protein binding at key circadian regulatory regions – a key regulatory node of circadian clock function Using a CRISPR/Cas9-APEX labelling method (CASPEX), we will first characterize the circadian chromatin landscape of the three main circadian regulatory regions (i.e. E-boxes, RREs, D-boxes). We expect to find new clock modifiers, whose role for circadian rhythm generation will be investigated in a subsequent part of the project, using an RNAi-based secondary screen. Overall, this project will provide novel insights in the circadian oscillator mechanism in humans, which is essential for developing better treatment strategies for circadian clock-associated disorders.

Keywords: circadian rhythms,chronobiology,circadian clock
Personalized, bio-engineered skin grafts for the permanent treatment of skin defects. (denovoSkin)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Switzerland
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-01-01
End date: 2018-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Every year in the world, more than 50M patients suffer from skin defects (e.g. burns, excision, etc.) and need surgical intervention to restore skin function. Standard of care, skin autografting, very often leaves these patients with scars. Scars are permanent and disfiguring, and can also be painful and highly debilitating. Indeed, they may also impair movement and growth, and require several follow-up surgeries, intense homecare and psychosocial rehabilitation. Hence, scars significantly affect patient’s quality of life, along with the economic burden for the health-care system. Furthermore, in the case of large wounds, donor site shortage represents a real clinical issue. denovoSkin™ is a patented, personalized, bio-engineered human skin graft classified as Advanced Therapy Medical Product (ATMP). It is engineered in large quantities starting-off from a stamp-sized skin biopsy of the patient, thus solving the donor site shortage issue. Moreover, because of its dermo-epidermal structure, denovoSkin is expected to minimally scar after transplantation. Its outstanding performance could considerably reduce or even avoids further corrective interventions, allowing for considerable savings in terms of costs. denovoSkin™ is granted with Orphan Drug Designation for the treatment of burns by Swissmedic, EMA and FDA. So far, more than €14M have been invested over the last 16 years of research into the development and the clinical testing of denovoSkin™. To have denovoSkin™ fully projected at a European and global level we need a further investment of €3.57M to set up a solid EU value chain able to meet the large demand expected during the commercialisation via developing the automation of manufacture. The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of denovoSkin™ and its market uptake.

Keywords: skin,bioengineering,burns,scars
Effect of polyinsatured fatty acids omega-3 (PUFAS n-3) supplementation during early embryo development on embryo viability in (mammals) sheep. (NUTREPHEALTH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-02-01
End date: 2022-05-20
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

It is well known, that an adequate fertility rates has important outcomes in different species of mammals (including human). However, despite the efforts to maintain outstanding reproductive performance, the reproductive failures are still considerable. This reproductive failure is related to a failure in maternal-embryo communication. In this sense, nutritional factor is one of the most important issues involved in the reproductive efficiency. Some studies have indicated that the use of polyunsatures fatty acids (PUFAS) like omega-3 have a positve effects on human and animal health. Nowadays, the effects of diets rich in PUFAS omega-3 (PUFASn-3) on reproductive physiology have been studied assensing the follicular function, ovulation rate and oocyte quality. In addition, there is scarce information about of the mechanism and/or effectiveness of PUFASn-3 during peri-implantational period in mammals. However the outcomes obtained have been controversiel and non-conclusive, justifying the necesity to perform futher studies. Thus, the combined use of morphologic studies, hormonal assays, genomics and proteomics procedures and embryo recover/transfer technologies could be suitable methodologies to evaluate the effects of PUFASn-3 during peri-implantational period. Also, these tools could evaluate the maternal/endometrial signal (e.g: receptors expression) and gene embryonic expressions during this period. In consequence, these studies could assess the effectiveness of PUFASn-3 on maternal and/or embryo’s level. The results obtained, will contribute to enhance the productivity in animal production system. Furthermore, the use of ovine species has been a classical experimental model in human medical studies. Thus, the awarness obtained in this proposal would contribute to increase the fertility rate in women with reproductive failure during this periodreinforcing the inter/multidisciplinary dimension of this proposal (impacting in life science and agricultural fields).

Keywords: reproductive biology,animal science,nutrition,polyunsatured fatty acid,fertility,mammals
INDustrial TECHnologies 2018 - innovative industries for smart growth (INDTECH2018)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Coordination and support actions
Countries involved: Austria
Call: Presidency events (H2020-NMBP-CSA-2017, 2017)
Start date: 2017-10-01
End date: 2019-02-28
Duration (months): 17.0
Total project cost (EUR): 1216638.75
EU funding (EUR): 600000.0
Participants: 2
Project status: CLOSED

The economical capacity of Europe is dependent on material goods production and industry. In the European Union, competitive production is central to economic growth. To meet the pressure of globalization, demographic developments in population and job markets, and challenges of increasing resource shortage as well as the demands for energy efficiency and highest environmental standards it is crucial that public authorities, industry and research work together. Industrial production is changing fundamentally. New, aggressive competitors, especially from the BRIC countries, and in the foreground China, offer production conditions at far lower cost than in Europe. In Europe competitive goods production is based on highly qualified experts and a high de-gree of mechanization. Intelligent production technologies and processes are necessary for a competitive and efficient production of material goods. Innovative, reasonable, ecologically friendly as well as qualitative products and services are possible only on the basis of innova-tive production and process technologies. R&D to improve production technologies and processes for the whole manufacturing sector are essential. Key enabling technologies are essential to broaden the industrial basis of manufacturing industry. The conference “MAde in euroPE 2030 - innovative industry for smart growth” will focus on - Presenting new industrial applications of applied research on Nanotechnology, Materi-als and Advanced Production - Feedback from the community providing policy advice - Presenting of first insights in the upcoming FP9 of the European Commission - The networking for industry and research Europe’s industrial future is dependent on specific modernizations of production processes; "Smart Production" of new, competitive and sustainable products. Research in Key enabling technologies in industry and science in cooperation with public authorities is speeding up.

Keywords: presidency event
Decoding Coupled Folding and Binding via Single-Molecule characterization of Ancient IDP protein-protein Interactions (evoDISFOLD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Intrinsically Disordered Proteins (IDPs) are characterized by their inability to spontaneously fold into a defined 3D structure. Nonetheless, many IDPs are able to undergo disorder-to-order transitions upon binding to interaction partners, in a process known as coupled folding and binding. Although different mechanisms have attempted to rationalize this process, technical limitations have prevented from deciphering the underlying principles of coupled folding and binding. Here, I will tackle this biological problem by introducing a novel, highly interdisciplinary approach integrating, for the first time, optical tweezers (OT) and single-molecule FRET (smFRET) to resolve the microscopic steps in coupled folding and binding; and Ancestral Sequence Reconstruction (ASR) as a rational strategy to guide protein engineering. For this purpose, I will study the nuclear co-activator binding domain (NCBD) and its multiple polypeptide binding partners (both intrinsically disordered and structured) as a model to resurrect, using customized ASR methods, the sequences of interacting pairs at multiple divergence nodes along a wide evolutionary scale. Then, I will characterize their intermolecular binding and intramolecular conformational dynamics with OT/smFRET. This cutting-edge project will result in the determination of mutational trajectories defining i) the emergence of coupled folding and binding, ii) the evolution of this process, and iii) the impact of promiscuous binding to multiple partners on its evolution. This data will allow to extract the essential determinants of coupled folding and binding.

Keywords: intrinsically disordered proteins,disorder to order transitions,single molecule biophysics,protein protein interactions,protein evolution
New cooperative business models and guidance for sustainable city logistics (NOVELOG)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Austria,Spain,Italy,Italy,Italy,Italy,Greece,Poland,Belgium,Greece,Greece,Greece,Belgium,Sweden,Greece,France,Netherlands,United Kingdom,Denmark,United Kingdom
Call: Reducing impacts and costs of freight and service trips in urban areas (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 4413842.0
EU funding (EUR): 4413842.0
Participants: 30
Project status: CLOSED

Urban areas represent the greatest challenges for freight transport and service trips, both in terms of goods distribution and service allocation performance, and environmental impacts (air emission, traffic congestion, road safety, accidents and noise). The salient scope of the proposal is the enabling of knowledge and understanding of freight distribution and service trips by providing guidance for implementing effective and sustainable policies and measures. This guidance will support the choice of the most optimal and applicable solutions for urban freight and service transport, and will facilitate stakeholder collaboration and the development, field testing and transfer of best governance and business models. This shall be achieved through: - the targeted understanding of urban freight and service trips, fostered by data collection on city logistics, - field testing and implementation of representative city logistics measures, - the development and application of a modular, integrated, evaluation framework for the assessment of these measures - the development of a typology between cities and potential city logistics components, and - the provision of guidance to cities, shaping consistent implementation channels for successful solutions, all according to the local needs and constraints. These activities will be accompanied by the production of practical tools that could support the take-up impact of NOVELOG project to wider international city and industrial networks and beyond the project's lifetime. NOVELOG will contribute to the European Commission's research and policy agenda through the generation of sound knowledge that introduces a new approach to guidance strategies that supports a more sustainable urban environment.

Keywords: city logistics,guidance,sustainable business models,cooperative logistics,understanding,regulations,incentives,data collection,sump,policy integration,urban planning
NHM NIGHT5 (NHM NIGHT5)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: United Kingdom
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-05-01
End date: 2015-12-31
Duration (months): 20.0
Total project cost (EUR): 408821.0
EU funding (EUR): 270000.0
Participants: 1
Project status: CLOSED

Since 2010 NHM has successfully delivered four consecutive European Researchers’ Nights with increasing public participation and engagement year after year. NHM NIGHT5 aims to build on this experience to aid the delivery of at least five captivating events across the UK. NHM NIGHT5 aims to: • actively breakdown existing public stereotypes of researchers • drive home to the public an awareness of the role and value of science • inspire the next generation of young researchers and demonstrate the varied roles and careers open within science NHM has an outstanding record in public outreach programmes and this will be the largest effort of this kind that NHM has undertaken to-date. More than 18,500 participants will be greeted by over 500 researchers and PhD students delivering 250 different engaging activities and formats alongside 50 professional educators in a fun and stimulating atmosphere. With an estimated 150,000 researcher/public interactions taking place over two years, the impact on participants is expected to be profound, and at a reduced spend (compared to ERN2013) per head of €15.29 in 2014 dropping to €14 for an expanded programme in 2015 represents excellent value in fostering a long-term public engagement with science. Reinvigorated with a wider national element extended to include Manchester in 2015 the awareness campaign will ensure mass participation and a broader awareness of the NHM NIGHT5 project as well as the ERN across Europe with an audience reach of 34 million.

Keywords: nhm night5 aims to,actively breakdown existing public stereotypes of researchers
Fishfriendly Innovative Technologies for Hydropower (FIThydro)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Estonia,Austria,Germany,Germany,Germany,Germany,Spain,Germany,Spain,Germany,Switzerland,Norway,Switzerland,Switzerland,Switzerland,Norway,Belgium,France,France,United Kingdom,Portugal
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2016-RES-CCS-RIA, 2016)
Start date: 2016-11-01
End date: 2021-04-30
Duration (months): 54.0
Total project cost (EUR): 7171550.16
EU funding (EUR): 5888423.91
Participants: 27
Project status: CLOSED

FIThydro addresses the decision support in commissioning and operating hydropower plants (HPP) by use of existing and innovative technologies. It concentrates on mitigation measures and strategies to develop cost-efficient environmental solutions and on strategies to avoid individual fish damage and enhancing population developments. Therefore HPPS all over Europe are involved as test sites. The facilities for upstream and downstream migration are evaluated, different bypass systems including their use as habitats and the influence of sediment on habitat. In addition existing tools and devices will be enhanced during the project and will be used in the experimental set-ups in the laboratories and at the test sites for e.g. detection of fish or prediction of behavior. This includes sensor fish, different solutions for migration as e.g. trash rack variations, different fish tracking systems, but also numerical models as habitat and population model or virtual fish swimming path model. Therefore a three-level-based workplan was created with preparatory desk work at the beginning to analyze shortcomings and potential in environment-friendly hydropower. Following the experimental tests will be conducted at the different test sites to demonstrate and evaluate the effects of the different options not covered by the desk-work. Thirdly, these results are fed into a risk based Decision Support System (DSS) which is developed for planning, commissioning and operating of HPPs. It is meant to enable operators to fulfill the requirements of cost-effective production and at the same time meet the environmental obligations and targets under European legislation and achieve a self-sustained fish population.

Keywords: hydropower
Innovative Methods for Psychology: Reproducible, Open, Valid, and Efficient (IMPROVE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2022-11-30
Duration (months): 66.0
Total project cost (EUR): 1999747.5
EU funding (EUR): 1999747.5
Participants: 1
Project status: SIGNED

With numerous failures to replicate, common misreporting of results, widespread failure to publish non-significant results or to share data, and considerable potential bias due the flexibility of analyses of data and researcher’s tendency to exploit that flexibility, psychological science is said to experience a crisis of confidence. These issues lead to dissemination of false positive results and inflate effect size estimates in meta-analyses. This leads to poor theory building, an inefficient scientific system, a waste of resources, lower trust in psychological science, and psychology’s outcomes being less useful for society. After having contributed to the literature highlighting these problems the goal of my ERC project is to improve psychological science by offering novel solutions to five vexing challenges: (1) I want to counter misreporting of results by using our new tool statcheck in several studies on reviewers’ tendency to demand perfection and by applying it to actual peer review. (2) I want to counter the biasing effects of common explorations of data (p-hacking) by professing and studying pre-registration and by developing promising new approaches called blind analysis and cross-validation using differential privacy that simultaneously allows for exploration and confirmation with the same data. (3) I want to counter the common problem of selective outcome reporting in psychological experiments by developing powerful latent variable methods that render it fruitless to not report all outcome variables in a study. (4) I want to counter the problem of publication bias by studying and correcting misinterpretations of non-significance. (5) I want to develop and refine meta-analytic methods that allow for the correction of biases that currently inflate estimates of effects and obscure moderation. The innovative tools I develop have the potential to improve the way psychologists (and other scientists) analyse data, disseminate findings, and draw inferences.

Keywords: research methods