Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Risk factors of work-related diseases - methods of evaluation and prevention (REWARD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-IRSES-2008, 2008)
Start date: 2009-02-01
End date: 2013-01-31
Duration (months): 48.0
Total project cost (EUR): 120600.0
EU funding (EUR): 120600.0
Participants: 1
Project status: CLOSED

The overall aim of the joint research programme is to enhance the research activities in study of the risk factors of work-related diseases with special emphasis paid to cardiovascular and musculoskeletal system. Cardiovascular and musculoskeletal diseases, are the main health problem both in western and developing countries Among occupational and environmental risk factors the important role plays work-related stress. It seems that influence of stress on cardiovascular and musculoskeletal systems could have common mechanism of pathogenicity, via neurovegetative disturbances, especially stimulation of the sympathetic and depression of the parasympathetic nervous system. The problem of work-related stress and its health consequences is particular important in countries in transitions as for example Russia or Ukraine, where changing in nature of work and globalisation cause that people have to deal with increasing work-related stress. This problem is poorly recognize. The transfer of knowledge will be implemented by various activities: training programmes, including a series of researches’ visits to the Work Physiology and Ergonomics Department of Nofer Institute of Occupational Medicine in Lodz, Poland and visits our staff at partners institutions from Norway, Denmark, Great Britan, Sweden, Hungary, Italy, Russia and Ukraine. Moreover networking activities and pilot studies are planned. The transfer of knowledge and know-how regarding risk factors of work related diseases will increase the potential for designing joint research projects and will be helpful in preparing proposals within FP7. Research activities within our project will contribute to reducing the CVD and MSD epidemic throughout: better management of occupational risk factors, use of the available more technological advances for improve working conditions, methodological advances in cardiovascular and musculoskeletal system evaluation in workers exposed to occupational risk factors.

Keywords: risk factors,work environment,cardiovascular and musculoskeletal diseases,work- related stress
Disease and immunity in marine brown algae (DIMBA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2008-09-01
End date: 2011-08-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The first-ever genome project on a seaweed (Ectocarpus siliculosus) presents an unprecedented opportunity to study an algal host-pathogen interaction with state-of-the art molecular approaches. This model has the strength of being both of environmental and fundamental relevance, enabling issues to be addressed ranging from the impact of diseases in marine ecosystems to the evolution of pathogenicity among protists. As a Marie Curie IEF Fellow, I have been setting up a laboratory-controlled pathosystem involving the oomycete pathogen Eurychasma dicksonii and developed robust protocols on this model. My results demonstrate, for the first time in brown algae, the existence of a genetically-determined immunity, most probably mediated by programmed cell death and conserved across the whole phylum. The aim of this proposal is to build on my current work and support the following long term research objectives: 1) Investigating complementary aspects of the defence mechanisms of brown algae: a) programmed cell death as a component of Ectocarpus innate immunity; b) metabolite profiling of algae suceptible or resistant to infection, with the potential of identifying new bioactive (antifungal) compounds 2) Deciphering some infection mechanisms of Eurychasma, through a cDNA-based gene discovery approach. As Eurychasma is the most basal oomycete known so far, this undertaking will give unprecedented insights into the evolution of infection strategies within this lineage, and more generally among protists. 3) Looking for molecular signatures of host-pathogen coevolution in the field, as a contribution to the understanding epidemic impact on algal populations and coastal ecosystems. During the course of this work, a proactive approach will be used towards the identification of bioactive natural compounds or conserved drug targets, potentially resulting in spin-off findings applicable to the development of improved strategies to combat disease in agronomy and medicine.

Keywords: aquatic biology,phytopathology,genomics,proteomics,cell biology,secondary metabolites (plant physiology)
Children in the crossfire: The cumulative effect of political violence, parent-child relations, and individual characteristics, on the development of aggression. (CHILDREN AND WAR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2008-11-04
End date: 2012-11-03
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

In societies around the world, millions of children experience political violence in the form of armed conflict as a fact of daily life. Most research on the psychological well-being of these child victims focuses primarily on trauma-related symptoms. However, these traumas are added to existing developmental risks children face due to individual, family, and relational factors. Among the most common childhood problems are aggression and oppositional behaviors, which have been suggested in the context of armed-conflict. Social learning theory conceptualizes violence as a learned phenomenon, developing through both direct and observational learning, making Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD) of particular interest in the context of political violence. ODD and CD are also associated with multiple interacting risk factors including quality of parenting. Attachment theory offers an intriguing formulation of protection and risk that links parent-child relations to children’s aggression. Indeed, the few studies that have examined the role of parent-child relations on the development of adverse psychological symptoms in children exposed to armed-conflict, have pointed to family dysfunction as a critical risk, highlighting the need to further understand the impact of armed conflict in the context of individual and family risks. Thus, the current proposal aims to examine the development of behavior problems in Israeli children living in a chronic state of political violence due to the ongoing Israeli-Palestinian conflict, accounting for individual, family and child-parent relationship factors. It details a 2.5-year longitudinal study to examine the trajectory of ODD and CD as related to fluctuations in political violence, to further comprehend the short-term and long-term contributions of parenting, parent mental health, and attachment behaviors to the development and maintenance of these disorders in an environment of unpredictable violence.

Keywords: child development,political violence,developmental psychopathology,parent-child relations,attachment,aggression,school-aged children
The Strong, the Weak and the Cunning: Power and Strategy in Voting Games (SWEAC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Hungary
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2008-09-30
End date: 2011-09-29
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 2
Project status: CLOSED

The recent extensions of the European Union brought a priori measures of voting power (power measures or power indices) in the spotlight. Originating from game theory these measures serve as indicators of the voting powers of players in a given voting situation. However, a priori measures of voting power are no more than statistical expectations of power as a result of random voting and therefore power indices lack the game theoretical features attributed to them. We rebuild these game theoretical foundations by introducing strategic power indices: we expand the model by allowing players to reject particular coalitions and thereby possibly increase their power. We characterise strategic power indices and apply them to real-life voting situations, such as the European Union’s Council of Ministers. We discuss implications to values, in particular the Shapley value. Further, we extend these models to farsighted players, players with preferences, such as for games on convex geometries and for games on networks. We also consider a modification of strategic power indices where players can renegotiate blocked coalitions and in these negotiations different credits can be given to critical/pivotal players in the same coalition. Finally, we develop a model to calculate the “true” power of a winning coalition in a parliamentary voting situation, where the power of a particular coalition belongs to the interval [0,1] to reflect the margin by which it is winning/losing.

Keywords: economic theory,political sciences,game theory
Industrial upgrading and regional development effects of the Czech and Slovak automotive industries (AUTOMOTIVE INDUSTRY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Czechia
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2008-11-03
End date: 2012-11-02
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The proposed project aims to study the effects of automotive foreign direct investment (FDI) on industrial upgrading and regional economic development in the Czech Republic and Slovakia. The research project is designed to deliver policy recommendations contributing to the effective implementation of the EU Cohesion and Regional Policies; and allows the principal investigator to develop a personal network for future international research collaboration dealing with the effects of FDI, the automotive industry and regional development in the context of the EU. The knowledge will be transferred to the host institution, Charles University in Prague, in the form of teaching, training and supervising both pre- and post-doctoral students. As the automotive industry has become a leading industrial sector in both countries, the research project studies its effects on national and regional economic development. The research particularly focuses upon the evaluation of FDI effects on industrial upgrading, development of supply linkages with local small and medium sized enterprises, and the transfer of knowledge from foreign-owned to domestic companies. The research project also aims to evaluate regional assets and advantages for the automotive industry and to what extent they fit the strategic needs of transnational corporations. The project uses an interdisciplinary approach as it draws on research traditions in three different disciplines: research on regional development and production networks in economic geography, research on FDI, automotive industry and spillover effects in economics, and research on global value chains and economic embeddedness in industrial sociology. The financial support to the proposed project will allow the re-integration of the highly experienced US-based researcher back to his home institution in the Czech Republic and thus will further support the competitiveness and attractiveness of the European Research Area.

Keywords: human geography,regional development,automotive industry,foreign direct investment,spillovers,industrial upgrading,czech republic,slovakia
Landscape archaeology in southern Etruria (LANDARCHETR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2008-09-30
End date: 2011-09-29
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

THE APPLICATION AND DEVELOPMENT OF NOVEL TECHNIQUES OF LANDSCAPE ARCHAEOLOGY IN SOUTHERN ETRURIA (CENTRAL ITALY). The objectives of this research project are the development and testing of new techniques of archaeological surveys (G.I.S.; LiDAR; G.P.R.) in some key-contexts of Southern Etruria (central Italy) to get new data on landscape archaeology and new tools for preservation of monuments and archaeological artefacts. The two key contexts are: the Etruscan city of Civita di Grotte di Castro and the territory of the ager faliscus between Falerii and Nepi. Both contexts were settled from the Bronze Age onwards and show dense archaeological evidence from the Prehistoric, Etruscan, Roman and Medieval phases, and it offers excellent opportunities for landscape analysis. Both areas are characterised by different land uses (forest, arable lands) which enables the use of different methodologies of survey and non-destructive analysis.

Keywords: landscape archaeology,etruria,ground penetrating radar,g.i.s.,l.i.d.a.r.,survey,city-states,frontiers
Single-Molecule Fluorescence Pulsed Interleaved Excitation, a novel tool to study biomolecular interactions (SMF-PIE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2008-12-10
End date: 2011-12-09
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

During the last few years, single-molecule fluorescence (SMF) methodologies have revolutionized the accessible information on biomolecular complexes, molecular dynamics, and biological mechanisms. Novel and important structural and dynamic insights can be obtained by studying molecules one by one, particularly into biological processes. In this field, the development of new methodologies and tools, on one hand, and of new improved fluorophores, on the other, are two major lines of research. In the current proposal, a cutting edge SMF methodology will be implemented: SMF Pulsed Interleaved Excitation (PIE) with two-colour coincidence detection, a technique that allows alternating excitation of fluorophores of different colours acting as donor and acceptor in fluorescence resonance energy transfer (FRET) processes. SMF-PIE has several advantages over the conventional SMF schemes to study biological systems, such as accurate determination of FRET efficiencies and inter-fluorophore distances, effective removal of the spectral, or distinction between molecules that have a low FRET efficiency from those that lack acceptor tag. The instrument performance will be calibrated and validated using model samples. Subsequently, SMF-PIE will be applied in three multidisciplinary biophysical approaches: 1) testing the feasibility and performance of newly synthesised fluorescein derivatives for SMF studies; 2) the resonance energy transfer between the new dyes acting as FRET donors and a DNA intercalator fluorophore as acceptor will provide insights into the mechanisms of intercalation of these carcinogenic molecules; 3) SMF-PIE will be employed to study the early pre-fibrillar aggregates from an amyloidogenic protein, the SH3 domain of α-spectrin, providing insights into the amyloid fibril formation mechanisms, a major biophysical and biomedical challenge nowadays.

Keywords: molecular biophysics,photochemistry,nanobiotechnology,single-molecule biophysics
Stability in algebraic geometry and its relationship with canonical Kahler metrics (STABILITYMETRICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2008-10-01
End date: 2012-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The proposal centers around the conjectural equivalence between the existence of special Kahler metrics and stability notions for projective manifolds coming from Geometric Invariant Theory. The stability condition is called K-stability, and the metrics in question are the extremal metrics, which includes the class of Kahler-Einstein metrics and the constant scalar curvature Kahler metrics. The projects will build on what is already known in this area and extend it to apply beyond projective manifolds, as well as connect with other parts of algebraic geometry, notably and stability notions for vector bundles and for pairs in birational geometry.

Keywords: algebraic geometry,geometry,kahler metrics,extremal metric,stability
Automated Real-Time Broad Band Seismology in the Azores-Gibraltar region (ART-SEIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-01-15
End date: 2013-09-12
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

Earthquakes cause great damage to societies at all levels. Recognizing that geophysical observations are essential for the mitigation of natural disasters the Portuguese Foundation for Science and Technology (FCT) recently created the National Geophysics Network (RNG) – a geophysical monitoring network managed by a consortium of academic and non-academic national institutions. Project ART-SEIS aims at contributing to the mitigation of seismic risk in the Portuguese territory, taking advantage of the new research infrastructures of the RNG. We propose to develop an effective and sustainable seismic monitoring system that allows for the generation of near-real-time earthquake-information after an earthquake, and rapid response in case of disaster. In order to accomplish this overall goal, we have defined four specific objectives: 1) To develop a seismic system that will allow rapid response to earthquake disasters in Portugal by rapidly computing the earthquake location, magnitude, style of faulting and maps of ground shaking (shakemaps); 2) To implement a set of algorithms for high-quality estimate of earthquake parameters (hypocenter, magnitude and moment tensor) taking into account the specific geographic situation of Portugal; 3) To investigate and implement procedures that reduce the operational costs of the seismic networks using the available technologies (cheap and effective data transmission, automation of routines, etc) in order to render its operation sustainable in time; and 4) To advocate and promote the implementation of the solutions identified and developed in the project by the national authorities, in the scope of the recently created RNG. We propose to set-up this seismic system using state-of the-art software and techniques (e.g., use of SeisComP3 software, VSAT telemetry, sparse-network techniques, non-linear location algorithms) and in close interaction with ongoing EU projects that address related issues (e.g., NERIES, SAFER).

Keywords: earthquakes,risk mitigation strategies (geophysics),disaster preparedness (geophysics,disaster management (geophysics)
Transplantation of magnetic-labelled vascular cells and cardiomyocytes isolated from human embryonic stem cells in a bioactive injectable gel for myocardium regeneration after infarct (HEARTREGENERATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-04-01
End date: 2013-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Cardiovascular diseases remain the number one cause of death in the western world. Human embryonic stem cells (hESCs) represent a promising source of cells for the treatment of cardiovascular diseases because of their unlimited cell propagation and ability to give rise to different cell types, including cardiomyocytes, endothelial and smooth muscle cells. Cardiomyocytes isolated from hESCs have been shown to form new myocardium after infarct; however, the functional recovery of the myocardium was low and the functional coupling was inexistent since the cardiomyocytes were observed within the scar and not in direct contact with host cardiomyocytes (Laflamme et al., Nat Biotechnol 2007). So far, no studies have reported the benefits of prevascularizing cardiomyocyte cell constructs to enhance in vivo cell viability, grafting and functional coupling. Additionally, we anticipate that the transplantation of these cells using an injectable bioactive gel will enhance cell retention and viability at the injection site. This projects aims at evaluating the neovascularization and myocardium functional recovery after transplanting hESC-derived cardiomyocytes and vascular cells into a myocardial infarction animal model. Recently, we isolated endothelial and smooth muscle cells from hESCs that form microvessels when injected subcutaneously in nude mice and thus might be an important cell source for the vascularization of the myocardium. In addition, this projects aims at developing a bioactive injectable gel to function as a temporary three-dimensional scaffold and a protocol to monitor non-invasively in vivo cell grafting.

Keywords: stem cells,tissue engineering,myocardial infarction,biomaterial engineering,nanotechnologies,vascularization