Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Structural basis of co-transcriptional pre-mRNA 3’-end processing (POL2-TERM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

RNAs transcribed by RNA polymerase II (Pol II) undergo numerous modifications before becoming export competent mature mRNA. One key step is the addition of the poly-adenine (poly-A) tail, which involves cleavage of the pre-mRNA from the growing RNA chain and the subsequent polyadenylation by poly-A polymerase. This cascade of events is known collectively as 3’-end processing and is one of the least understood steps of mRNA biogenesis. Pol II plays a vital role in recruiting and assembling the 3’-end processing machinery onto the nascent RNA, but the structural basis of transcription-coupled 3’-RNA processing is yet to be elucidated. This project aims to bring together the fields of transcription and 3’-end processing in order to understand how poly-A tails are added onto pre-mRNA in the context of actively transcribing Pol II. The most advanced methods of protein expression in recombinant systems as well as the extraction of complexes from native source will be coupled with state-of-the-art electron microscopy analysis to determine the structural basis of co-transcriptional 3’-end processing. Complementary biophysical methods will be used to map macromolecular interactions, and biochemical assays will be conducted to measure the impact of mutations introduced to characterize this fundamental biological process. The goal of this work is to provide the mechanistic basis for this essential step in mRNA biogenesis, and to understand human diseases that are resulted from aberrations in RNA production and processing.
Agile, eXtensible, fast I/O Module for the cyber-physical era (AXIOM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: A new generation of components and systems: Engineering of advanced embedded and energy and resource efficient components and systems
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Spain,Italy,Italy,Greece
Call: Smart Cyber-Physical Systems (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 3945937.5
EU funding (EUR): 3945937.5
Participants: 7
Project status: CLOSED

We are entering the Cyber-Physical age, in which both objects and people will become nodes of the same digital network for exchanging information. Therefore, in our imaginary, the general expectation is that “things” or systems will become somewhat smart as people, allowing rapid and close interactions not only system-system, but also human-system, system-human. More scientifically, we expect that such Cyber-Physical Systems (CPSs) will at least react in real-time, have enough computational power for the assigned tasks, consume the least possible energy for such task (energy efficiency), scale up through modularity, allow for an easy programmability across performance scaling and exploit at best existing standards at minimal costs. The whole set of these expectations impose scientific and technological challenges that need to be properly addressed. The AXIOM project (Agile, eXtensible, fast I/O Module) aims at researching new software/hardware architectures for CPSs to meet the above expectations. The technical approach aims at solving fundamental problems to enable easy programmability of multi-core multi-board systems through the open-source OmpSs programming model, leveraging Distributed Shared Memory (DSM) inspired concepts across the modules. The OmpSs will allow accelerating functions through an FPGA (Agility). In particular, to the best of our knowledge, this is the first time that DSM will be effectively demonstrated on an embedded modular system (eXtensibility). Modular scalability will be possible thanks to a fast interconnect that will enrich the module. To this aim, an innovative modular ARM-based board with enhanced capabilities for interfacing with the physical world will be designed and demonstrated in key scenarios such as Smart Video-Surveillance and Smart Living/Home (Domotic).

Keywords: embedded systems
Nucleic Acids for Future Gene Editing, Immunotherapy and Epigenetic Sequence Modification (NATURE-ETN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Germany,Ireland,Poland,France,Czechia,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-04-01
End date: 2024-03-31
Duration (months): 48.0
Total project cost (EUR): 4041816.48
EU funding (EUR): 4041816.48
Participants: 10
Project status: SIGNED

Nucleic acid (NAs) therapies are predicted to yield major advances in the treatment of human disease and new approaches in NA design are required to extend the boundaries of today`s gene editing technologies, cancer immunotherapies, and epigenetic base manipulation tools. Current gene editing technologies involving CRISPR-Cas9, despite their wide applicability, have serious limitations involving off-target or prolonged effects that produce mutations, insertions, and deletions leading to undesired therapeutic outcomes. Questions also remain regarding the development and delivery of NAs for manipulation of T-cells, now seen as the new paradigm in cancer research. NATURE-ETN will meet this challenge by engineering new biomaterials and therapies to extend the boundaries of i.) gene editing technology, ii.) cancer immunotherapy, and iii.) epigenetic base manipulation. Our research programme involves world-leading chemists and biologists in combination with high-tech/biotech SMEs and industry partners. We will use our combined expertise in NA chemistry, DNA crystallography, materials chemistry, cell culture, and epigenetic sequencing to develop an outstanding multi-disciplinary environment were 15 Early Stage Researchers will receive unrivalled research training in the most exciting gene therapy research today. The intersectoral training provided will encompass scientific and transferable skills, an understanding of industry, and features targeted workshops in sequencing and genomics along with quality/business management and future career planning. NATURE-ETN will leverage breakthrough discoveries—some originating from our own laboratories—to provide training excellence to give our fellows a deep skillset in the translation of basic research into high functioning commercial NA biomaterials. NATURE-ETN will develop the next generation of pioneering scientific leaders in Europe where they will grow our commercial need for disruptive technologies in 21st century medicine.

Keywords: nucleic acid therapy,crispr,gene editing,immunotherapy,epigenetics,dna crystallography,bioinorganic materials,dna oxidation,live cell imaging,dna triplexes
FEASIBILITY STUDY FOR THE RUBEDO CVM – INNOVATIVE OPTICAL COMPUTER VISION MODULE FOR UNMANNED VEHICLES (Rubedo CVM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Lithuania
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

One of the major driving forces for the depth perception market is the increasing use of mobile robots and drones for multiple applications. Without reliable vision and particularly depth perception unmanned vehicles are unable to detect obstacles and adaptively plan motion paths. Moreover, the new generation of robotic machines strongly depend on the ability to acquire, organize, and interpret surrounding visual data in real-time in order to stay aware of the environmental situation and act adequately. Robot and autonomous vehicle manufacturers or system manufacturers do not have the necessary skills, knowledge and know-how for computer vision development, therefore they would much rather use a standard computer vision solution. Currently in the market there is no truly affordable standardized stand-alone COTS 3D computer vision solution, which is capable of high resolution low power long range real-time optical depth sense with deep learning based natural object perception capabilities out of box – something, that is universally appreciated by many mobile robotic system manufacturers and integrators. Rubedo Sistemos has already developed and successfully tested a prototype of CVM (computer vision module) – the first affordable, compact low power long-range high-resolution real-time depth sense technology for 3D perception at longer distances for mobile robotics. Rubedo CVM has been designed as a maintenance-free standalone product which provides high definition images, accurate measure of the environment depth, and can be trained to extract natural objects of interest in real-time. Thorough analysis of market and user needs as well as an elaboration of a business plan is needed in order to ensure successful commercialization of Rubedo CVM. This feasibility study will help validating the market in addition to providing a stepping-stone for future preparation of investor readiness as well as serve as a roadmap for market replication of the product.

Keywords: computer vision,robotics,machine vision,depth perception,standardization
Critical Raw material ElectrocatalystS replacement ENabling Designed pOst-2020 PEMFC (CRESCENDO)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Italy,Germany,France,France,United Kingdom,United Kingdom
Call: Towards next generation of PEMFC: Non-PGM catalysts (H2020-JTI-FCH-2017-1, 2017)
Start date: 2018-01-01
End date: 2021-09-30
Duration (months): 45.0
Total project cost (EUR): 2739602.5
EU funding (EUR): 2739602.5
Participants: 10
Project status: CLOSED

CRESCENDO will develop highly active and long-term stable electrocatalysts of non-platinum group metal (non-PGM) catalysts for the PEMFC cathode using a range of complementary and convergent approaches, and will re-design the cathode catalyst layer so as to reach the project target power density and durability requirements of 0.42 W/cm2 at 0.7 V, and 1000 h with less than 30% performance loss at 1.5 A/cm2 after 1000 h under the FC-DLC, initially in small and ultimately full-size single cells tested in an industrial environment on an industrially scaled-up catalyst. The proposal includes the goal of developing non-PGM or ultra-low PGM anode catalysts with greater tolerance to impurities than current low Pt-loaded anodes. It will develop and apply advanced diagnostics methods and tests, and characterisation tools for determination of active site density and to better understand performance degradation and mass transport losses. The proposal builds on previous achievements in non-PGM catalyst development within all of the university and research organisation project partners. It benefits from the unrivalled know-how in catalyst layer development at JMFC and the overarching expertise at BMW in cell and stack testing, and in guiding the materials development to align with systems requirements.

Keywords: non pgm catalyst,catalyst stability,catalyst layer
Feasibility study for market introduction of the T-Minus DART research rocket system (DART)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Netherlands
Call: Engaging SMEs in space research and development (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The notion that a better understanding of the Earth system in terms of climate and space interaction is required for human well-being is recognized globally. This requires more systematic observation of the Earth’s atmosphere system and Earth-space interaction at a resolution and accuracy that cannot always be provided through remote sensing. Therefore, a need exists to supplement the Global Earth Observation System of Systems (GEOSS) and the EU Copernicus programme with in-situ measurements in order to cover observation gaps to calibrate and validate remote-sensing data and to deliver Earth Observation services, including monitoring variables, for policy makers, local users and citizens. One observational gap exists in the atmospheric layers between 50 and 120 km, where satellites and balloons are not usable as experiment platform. This innovation project aims to provide a technical solution, the T-Minus DART, enabling in-situ experiments in these highest atmospheric layers. Using innovations such as a carbon fibre booster, micro-payloads and integral design approach, a very cost-effective and easy-to-use vehicle was developed, leading to a 90% reduction in operational cost with respect to the current state of the art. This makes the DART interesting for research institutes, but also for universities and rocket launch sites. Market studies show that 15-20 sales per year are feasible in the first three years of commercialization, and that this number grows to 60-100 in 10 years. Within the SME phase 1, a feasibility study will be performed that addresses the final steps required for commercialization: a detailed survey of user demands, formation of a European consortium for executing two demo launch campaigns and addressing the regulations regarding transport and operations. It leads to an elaborated business plan and market implementation roadmap.

Keywords: sounding rocket,high atmosphere research,in situ experiments,cost effective,payload miniaturization
Controlling Photoinduced Transitions with Strong Light Pulses in Condensed Matter. (StrongLights)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

In this proposed project “Controlling Photoinduced Transitions with Strong Light Pulses in Condensed Matter” (StrongLights), the experienced researcher Dr. Joaquim Jornet Somoza and the expert in the field, Prof. Angel Rubio of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD), in collaboration with top international experimental groups, will work with the aim of acquiring theoretical results in order to find novel electronic properties for future advances in nanoelectronics, photoelectronics and plasmonics. To do this, we will focus on the theoretical description of the ultrafast photoinduced phase transitions (PIPT) at multilevel time scales (from atto- to picoseconds) to establish a theoretical and computational platform to understand and control this non-equilibrium phenomena. We will perform state-of-the-art first-principles simulations using the most advanced exchange-correlation functionals developed in the host group. We will characterise the vibrational influence of the lattice in the optical and charge transport properties using many-body perturbation approaches such as the GW self-energy method and the Bethe-Salpeter equations, and real time propagation-time dependent density functional theory (P-TDDFT) to catch the non-linear dynamical processes involved in PIPT. Moreover, strong optical pulses have recently emerged as powerful tools to manipulate and control complex condensed matter systems with strongly correlated electrons. In this project we plan to go beyond by controlling electronic properties not only of the ground state, but for the first time on excited states. By mixing and matching different of light pulses, we will be able to create new meta-stable states that have new and unexpected properties that are different from any steady state having profound impacts in novel applications on condensed matter physics, material science, as well as nano- and bio-science.

Keywords: electron phonon dynamics,first principle calculations,time dependent density functional theory,many body perturbation theory,nanoplasmonics,photoelectronics
Sharing Researchers’ Passion for Evidences and Resilience (SHARPER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy,Italy,Italy,Italy,Italy,Italy
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-05-10
End date: 2019-12-09
Duration (months): 19.0
Total project cost (EUR): 1121203.75
EU funding (EUR): 790400.0
Participants: 8
Project status: CLOSED

The SHARPER goal is to make the researchers’ passions accessible and comprehensible to everybody, starting from young generations, through engaging communication formats and activities that take place in unusual venues and make the researchers’ life a shared experience with a large audience in Italy. Researchers are evidences hunters, their passion for facts, data and observations collected, accumulated and interpreted with a constant and patient day by day activity, is one of the researchers’ main features. It is usually combined with their ability and commitment to use these evidences to tackle some of the more complex issues that are relevant to all of us: from fundamental research problems such as those related to the origin of the Universe or the structure of our brain to technological endeavours and societal challenges. The constant quest for evidences reveals, not only their insatiable curiosity but also their passion for challenging the limits of our knowledge and innovate going beyond the known, being able to accept and adapt to the changes or, in a sentence, to show a profound passion for resilience. The combination of these researchers’ passions for identifying and understanding facts and for wisely adapt and evolve by innovating and the opportunity for citizens to meet them, seems to be vital in a constantly changing society.. The acronym SHARPER - Sharing Researchers’ Passion for Evidences and Resilience summarizes all these elements and is the name of the European Researchers’ Night in Italy that will take place on the 28th of September 2018 and on the 27th of September 2019 simultaneously in 11 cities: (North Italy) Trieste (hosting city of ESOF 2020) Pavia; (Centre Italy) Ancona, Macerata, Perugia, L'Aquila; (South Italy) Napoli (Sicily) Palermo (Italian Capital of Culture 2018), Catania (Sardinia) Cagliari and Nuoro.

Keywords: science,passion,engagement,researchers,excellence,cities,evidences,stem,responsibility,innovation,education,italy,entertainment,technology,tinkering,performances,night
Energy- and Size-efficient Ultra-fast Plasmonic Circuits for Neuromorphic Computing Architectures (PlasmoniAC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Israel,Germany,Switzerland,Belgium,Greece,France,France,France,United Kingdom
Call: Unconventional Nanoelectronics (H2020-ICT-2019-2, 2019)
Start date: 2020-01-01
End date: 2023-09-30
Duration (months): 45.0
Total project cost (EUR): 4114926.25
EU funding (EUR): 3999458.75
Participants: 12
Project status: SIGNED

PlasmoniAC invests in neuromorphic computing towards sustaining processing power and energy efficiency scaling, adopting the best-in-class material and technology platforms for optimizing computational power, size and energy at every of its constituent functions. It employs the proven high-bandwidth and low-loss credentials of photonic interconnects together with the nm-size memory function of memristor nanoelectronics, bridging them by introducing plasmonics as the ideal technology for offering photonic-level bandwidths and electronic-level footprint computations within ultra-low energy consumption envelopes. Following a holistic hardware/software co-design approach, PlasmoniAC targets the following objectives: i) to elevate plasmonics into a computationally-credible platform with Nx100Gb/s bandwidth, um2-scale size and >1014 MAC/s/W computational energy efficiency, using CMOS compatible BTO and SiOC materials for electro- and thermo-optic computational functions, ii) to blend them via a powerful 3D co-integration platform with SixNy-based photonic interconnects and with non-volatile memristor-based weight control, iii) to fabricate two different sets of 100Gb/s 16- and 8-fan-in linear plasmonic neurons, iv) to deploy a whole new class of plasmo-electronic and nanophotonic activation modules, v) to demonstrate a full-set of sin2(x), ReLU, sigmoid and tanh plasmonic neurons for feed-forward and recurrent neurons, v) to embrace them into a properly adapted Deep Learning training model suite, ultimately delivering a neuromorphic plasmonic software design library, and vi) to apply them on IT security-oriented applications for threat and malware detection. Succeeding in its targets will release a powerful artificial plasmonic neuron suite with up to 3 orders of magnitude higher computational efficiencies per neuron and 1 and 6 orders of magnitude higher energy and footprint efficiencies, respectively, compared to the top state-of-the-art neuromorphic machines.

Keywords: neuromorphic computing,plasmonics,photonics,plasmonic weights,linear neurons