Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Biopolus Aero Green - Feasibility Study (BAG-FS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Hungary
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2014, 2014)
Start date: 2014-09-01
End date: 2014-11-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The objective of the innovation project is to bring to market a high-yield, highly automated aeroponic plant cultivation system suitable for resource efficient, high quality vegetable and fruit production in a limited physical footprint. This core technology and the associated supporting services are expected to be enablers of the widespread appearance of urban farms. The system lessens agricultural land use. Moving production closer to the place of consumption enables reduction in transportation needs, emissions and food waste production. The aeroponic technology produces very high yields while using the fraction of water. The system has the following main economic benefits for the users: • year-round crop production • no weather-related crop failures • no use of pesticides, herbicides • use of 75-95 % less water than the same productive technologies • greatly reduced food-miles • higher food security and safety • high yield in crop production User needs met by the system: demand for products with trustworthy proof of socially and environmentally responsible business practices, demand for chemical-free food products. Targeted users are those SMEs and farmers who produce indoor, and those restaurants and supermarkets where day-to-day fresh fruits and vegetables are important. Economic benefits and ecological impact are the main appeals of the technology. The feasibility assessment’s goal is to quantify these advantages which are major milestones toward successful commercialization. Phase 2 plans are a first demonstration facility and building out full capacity of manufacturing. European dimension: Flagship sustainable biological technologies like Biopolus Aero Green system can help the EU secure its leading position to address ecological challenges and achieve economic growth. Global dimension: BAG system enables food production in urbanized areas and lessens dependence on outside sources and imported foods.

Keywords: aeroponic system,green solution,cultivation system,soilless crop production,reduced food miles,h food security
Spin conversion, logic storage in oxide-based electronics (SPICOLOST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,Argentina,Spain,Switzerland,France,United States,Japan
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-03-01
End date: 2022-08-31
Duration (months): 66.0
Total project cost (EUR): 711000.0
EU funding (EUR): 693000.0
Participants: 9
Project status: CLOSED

Nowadays, among of the main challenges in the rational and efficient use of the energy, the energy harvesting, energy saving and energy conversion are key points in the research and application of electronic devices. The optimization of device performances making them more powerful with less energy consumption while keeping an affordable production cost is mandatory. The present project will address those challenges by means of designing suitable materials for implementing on devices able to reduce the energy consumption. Nanotechnology, Oxide and Superconducting Spintronics will be the competitive edge technologies triggering the interconnection and cooperation between international labs and technological companies, from Europe and overseas by means of sharing knowledge, cross-linked working and innovation, gaining capacities towards this mission. SPICOLOST project will tackle this challenge with two parallel approaches: i) with suitable heterostructures with high efficiency conversion of thermal energy in electricity, taking the advantage of harvesting, the so called thermoelectric thermopile device based on Seebeck and Spin Seebeck Effects; and ii) producing multicomponent nanostructured materials for magneto-electronic and superconducting devices capable of fast signal processing minimizing the energy dissipation by control the magnetic switching, and then consuming less energy. It is expected to produce advances in experimental fabrication processes, better control of interface properties of hybrid heterostructures and explaining them with suitable theoretical framework that conduct to novel discoveries due to the synergy between Superconducting and Spintronic.

Keywords: thermoelectrics,artificial multiferroics,hybrid heterostructures on semiconductors,dft calculations
A metabolism-based prognostic biomarker for prostate cancer (MetaboMARKER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-06-01
End date: 2018-12-31
Duration (months): 19.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Prostate cancer (PC) is the most prevalent tumour type among men. The fraction of patients that exhibit disease recurrence can reach 15% and they face an uncertain future, since this type of tumour is prone to resist to subsequent therapeutic strategies. Current guidelines for treatment of PC include prostatectomy or radiotherapy as first line therapy for localized disease, and chemical castration followed by chemotherapy for recurrent PC. The lack of capacity to identify therapy responders vs. escapers in PC is one of the sources for its important mortality. The challenge resides in providing clinicians with a robust and affordable biomarker that informs about the success of first line therapy in localised PC, and that allows them to employ more intensive therapeutic strategies in high-risk patients. The development of such prognostic tools is urgently needed, since western societies are facing profound changes in the major PC risk factors, including age and obesity. Last, but not least, the cost of treating PC will progressively impose strong pressure in the public health system. In addition, patients that fail first-line therapy can be enrolled in subsequent therapies for up to a decade, and given their advance age (PC predominantly presents in the sixth decade of life) they frequently present endangering and costly co-morbidities and secondary effects. MetaboMARKER, a novel biomarker developed in the framework of the ERC-StG-336343-CancerMetab and already protected under a European patent, is able to differentiate patients harbouring a PC that would progress and potentially metastasize, from those that exhibited a disease that would not likely be a risk to their lives. Thus, MetaboMARKER may contribute to more efficient diagnosis, improved treatments and better distribution of funds in disease management. The aim of the present PoC is to further develop the final biomarker for its commercialization and define the best exploitation strategy plan.

Keywords: prostate cancer prognosis,biomarker,metabolism,metastasis,disease recurrence,personalized medicine
REliable power and time-ConstraInts-aware Predictive management of heterogeneous Exascale systems (RECIPE)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: High Performance Computing
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Italy,Italy,Switzerland,Poland
Call: Transition to Exascale Computing (H2020-FETHPC-2017, 2017)
Start date: 2018-05-01
End date: 2021-10-31
Duration (months): 42.0
Total project cost (EUR): 3318327.93
EU funding (EUR): 3285300.0
Participants: 8
Project status: CLOSED

The current HPC facilities will need to grow by an order of magnitude in the next few years to reach the Exascale range. The dedicated middleware needed to manage the enormous complexity of future HPC centers, where deep heterogeneity is needed to handle the wide variety of applications within reasonable power budgets, will be one of the most critical aspects in the evolution of HPC infrastructure towards Exascale. This middleware will need to address the critical issue of reliability in face of the increasing number of resources, and therefore decreasing mean time between failures. To close this gap, RECIPE provides: a hierarchical runtime resource management infrastructure optimizing energy efficiency and ensuring reliability for both time-critical and throughput-oriented computation; a predictive reliability methodology to support the enforcing of QoS guarantees in face of both transient and long-term hardware failures, including thermal, timing and reliability models; and a set of integration layers allowing the resource manager to interact with both the application and the underlying deeply heterogeneous architecture, addressing them in a disaggregate way. Quantitative goals for RECIPE include: 25% increase in energy efficiency (performance/watt) with an 15% MTTF improvement due to proactive thermal management; energy-delay product improved up to 25%; 20% reduction of faulty executions. The project will assess its results against the following set of real world use cases, addressing key application domains ranging from well established HPC applications such as geophysical exploration and meteorology, to emerging application domains such as biomedical machine learning and data analytics. To this end, RECIPE relies on a consortium composed of four leading academic partners (POLIMI,UPV,EPFL,CeRICT); two supercomputing centers, BSC and PSNC; a research hospital, CHUV, and an SME, IBTS, which provide effective exploitation avenues through industry-based use cases

Keywords: reliability,power,run time management,timing,exascale,heterogeneous computing,high performance computing
Ultra-flexible nanostructures in flow: controlling folding, fracture and orientation in large-scale liquid processing of 2D nanomaterials (FlexNanoFlow)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands,United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2023-03-31
Duration (months): 72.0
Total project cost (EUR): 1453779.0
EU funding (EUR): 805780.16
Participants: 2
Project status: SIGNED

2D nanomaterials hold immense technological promise thanks to extraordinary intrinsic properties such as ultra-high conductivity, strength and unusual semiconducting properties. Our understanding of how these extremely thin and flexible objects are processed in flow is however inadequate, and this is hindering progress towards true market applications. When processed in liquid environments to make nanocomposites, conductive coatings and energy storage devices, 2D nanomaterials tend to fold and break owing to strong shear forces produced by the mechanical agitation of the liquid. This can lead to poorly-oriented, crumpled sheets of small lateral size and therefore of low intrinsic value. Orientation is also a major issue, as ultra-flexible materials are difficult to extend and align. In this project, I will develop nanoscale fluid-structure simulation techniques to capture with unprecedented resolution the unsteady deformation and fracture dynamics of single and multiple sheets in response to the complex hydrodynamic load produced by shearing flows. In addition, I will demonstrate via simulations new strategies to exploit capillary forces to structure 2D nanomaterials into 3D constructs of desired morphology. To guide the simulations and explore a wider parameter space than allowed in computations, I will develop conceptually new experiments on “scaled-up 2D nanomaterials”, macroscopic particles having the same dynamics as the nanoscopic ones. The simulations will include continuum treatments and atomistic details, and will be analysed within the theoretical framework of microhydrodynamics and non-linear solid mechanics. By uncovering the physical principles governing flow-induced deformation of 2D nanomaterials, this project will have a profound impact on our ability to produce and process 2D nanomaterials on large scales.

Keywords: particulate flows
Gene network rewiring by an engineered CRIPSR-Cas12a variant (GNRECC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

In the last 10 years, an increasing number of studies employed -omics technologies to describe the molecular changes underpinning cellular functions. However, a large part of these findings is awaiting an experimental validation. This is due to the lack of efficient molecular tools able to control both multiple and distinct genetic interactions. Recently, I described a new CRISPR/12-based genome engineering tool that, for the first time, it provides the constitutive, conditional, inducible, orthogonal and multiplexed engineering of dozens of endogenous genes, simultaneously. In this research proposal, I aim to increase the efficiency of this platform in the context of multiplexed genome engineering applications, such as gene network rewiring. To this aim, I will use techniques inspired by the statistical physics of complex disordered systems, to design a more potent version of my CRISPR/Cas12-based genome engineering tool and, I will use this novel platform to rewire signaling pathways involved in cellular proliferation. This research proposal is structured into the following tasks: rational design of novel Cas12a variants, validation of novel Cas12a variants, gene network rewiring by a novel Cas12a variant. By coupling statistical physics to both protein and genome engineering this project will pave the way for efficient and large-scale engineering of gene networks.

Keywords: crispr cas12
MATching zeolite SYNthesis with CATalytic activity (SynCatMatch)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-06-01
End date: 2020-11-30
Duration (months): 66.0
Total project cost (EUR): 2470519.0
EU funding (EUR): 2470519.0
Participants: 1
Project status: CLOSED

Solid catalysts are key components of many industrial processes, offering advantages such as reuse and ease recovery. This research programme aims to develop a new concept and methodology for the synthesis of zeolite catalysts. Zeolites are solid, porous catalysts that have wide ranging industrial applications for gas adsorption, separation and catalysis. While a relatively large number of zeolites have been synthesised, zeolite selection as catalyst for a particular reaction still retains a large element of trial and error. Our objective is to design a zeolite synthesis methodology that creates pores and cavities in the resulting zeolite that approach a “molecular recognition” pattern to catalyze the desired reaction. The approach focuses on the study of the reactions transition states since it is accepted that the most efficient catalysts are those that lower the transition state energy in the reaction, boosting the catalytic activity and efficiency. We will study the transition state of the desired reaction and design and synthesise transition state mimics to be used as Organic Structure Directing Agents for the synthesis of zeolites. By maximizing the host-guest interactions between zeolite and transition state, the efficiency of the catalyst will be increased. We aim to obtain tailor made catalysts for a chosen spectrum of reactions that also have clear industrial applications. Synthesis of highly efficient catalysts for particular industrially relevant applications will lead to lower energy consumption, fewer by-products and lower consumption of reactants. In summary, this will result in more sustainable processes. In many industrial applications a 1% increase in selectivity can represent more than 3000Tm/year additional manufacturing in a single unit.

Keywords: molecular imprinting
BACK TO THE FUTURE (B-FUTURE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-04-01
End date: 2019-11-30
Duration (months): 20.0
Total project cost (EUR): 220000.0
EU funding (EUR): 160000.0
Participants: 1
Project status: CLOSED

The ”B-FUTURE _ Back to the Future” project is promoted by the Neuromed Foundation with the aim to push students getting closer to the fascinating world of research as "a gate from the past to the future", by offering the chance to meet young and communicative researchers, as well as experienced scientists and researchers involved in EU programs at international level. The main theme is “BACK TO THE FUTURE” to prove, through a significantly scientific path, how human life is always characterized by research and how the research is evolving. The objective is to drive visitors on an exciting journey in the world of science creating a path that starts from the origin of the species, through its development and observing the environmental changes and how they affect human life, up to the realization of Cyber Brain and man projected in the space. Why B-FUTURE? Because communicating science to younger people -particularly students of primary and secondary schools - it is important to demonstrate that being part of research is being the memory and the future at the same time. As in the famous film, participants will come back to the past to better know life origins and then projected to experience new technologies imagining what the 'next step' in that progression would be.Students will enter in the fantastic world of science where they will meet new characters "researchers", will make discoveries and will live exciting experiences in a stimulant and funny way. The researchers will be able to present themselves as people engaged and emotionally involved in the activities with a strong impact on society and everyday life, not as sad.Since the 2018 is designated as the “European Year of Cultural Heritage”, B-FUTURE will include cherishing few local venues of cultural heritage because, as research, cultural heritage shapes our identities and everyday lives. As for research, through heritage the past meets the future and celebrating the past can help us to build the future.

Keywords: scientific research,research awareness raising,young students,european research space,scientific career opportunities,neuroscience,cyber brain,health,environment,cultural heritage,robotics
A paradigm change in the treatment of blinding ocular diseases (TRS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 3461500.0
EU funding (EUR): 2423050.0
Participants: 1
Project status: CLOSED

Ocular inflammatory diseases – affecting hundreds of millions of people worldwide – impose a significant medical and economic burden on society and can lead to blindness. Today, corticosteroids are the most common method used to treat ocular non-infectious inflammation of any kind. Rather than treating the disease itself, however, steroids merely relieve its symptoms, and long-term use can result in devastating consequences. Our bio-inspired drug candidate is a non-steroid. It approaches inflammatory diseases from within the immune system and was developed to ‘re-engineer’ the immune system. Based on excellent preclinical results, we believe that this approach will have the capability to disrupt the immune mechanism that causes the disease in order to provide patients with a safe and long-lasting therapeutic effect, with the goal of saving them from blindness. Our platform technology has the potential to effectively treat a broad array of autoimmune and inflammatory diseases and to become a first in class, market approved molecule for local treatment of inflammatory ocular diseases. Our first target indication is uveitic glaucoma – a devastating orphan disease requiring urgent treatment and carrying high risk of blindness. Selecting an orphan indication as a market penetration strategy will grant us extended market exclusivity, tax reliefs and shorter time to market. In the project, we will perform a Phase I/IIa clinical trial. We will exploit the trial results to secure financing for further clinical development towards commercialization. The global ocular inflammation treatment market is expected to exceed more than US$ 500 Billion by 2024. As our first target indication has a significant unmet need with no approved treatment, we expect to gain 25% of market shares 5 years post launch, which would correspond to >€700 M in revenue for Tarsius in 2028 for uveitic glaucoma only. Profits will be reinvested to develop our product pipeline and expand our company.

Keywords: inflammation,blinding condition,biomimetics,uveitic glaucoma