Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mechanism of ATP Dependent Chromatin Modelling and Editing by INO80 Remodellers (INO3D)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 2201875.0
EU funding (EUR): 2201875.0
Participants: 1
Project status: SIGNED

Nucleosomes, ~147 base pairs of DNA wrapped around an histone protein octamer, package and protect nuclear DNA but also carry important biological information. The position and composition of nucleosomes along chromosomal DNA is a key element of defining the state and identity of a cell. Chromatin remodellers are ATP dependent molecular machines that position, move or edit nucleosomes in a genome wide manner. Collectively, they shape the nucleosome landscape and play central roles in the maintenance and differentiation of cells, but also in pathological transformations. INO80, a megadalton large remodeller consisting of 15 or more subunits, is involved in replication, gene expression and DNA repair. It models chromatin by positioning barrier nucleosomes around nucleosome free regions, editing nucleosomes and generating nucleosome arrays. However, structural mechanisms for INO80 and other remodelling machines are poorly understood due to their complexity. To provide a comprehensive mechanistic framework, to understand how INO80 senses nucleosome free regions to position barrier nucleosomes and how it generates arrays or senses DNA breaks, I propose a challenging but ground-breaking endeavour using a combination of cryo-EM and functional approaches. We address structures of fungal and human INO80 complexes at promoter regions, on di-nucleosomes and at DNA ends and develop quantitative positioning assays to reveal common and distinct features of shaping chromatin in different species. We also explore cryo-EM as tool towards revealing distinct steps the chemo-mechanical remodelling reactions. The proposed research will help derive fundamental molecular principles underlying the modelling of the nucleosome landscape.

Keywords: chromatin remodelling,nucleosomes,ino80,atpase,molecular machine
Analysis of the T cell’s Tactical Arsenal for Cancer Killing (ATTACK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Italy,France,United Kingdom
Call: ERC Synergy Grant (ERC-2020-SyG, 2020)
Start date: 2021-05-01
End date: 2027-04-30
Duration (months): 72.0
Total project cost (EUR): 9999019.0
EU funding (EUR): 9999017.0
Participants: 4
Project status: SIGNED

The ATTACK consortium will develop a new biotechnology based on harnessing a previously unknown natural cytotoxic mechanism of T cells to fight cancer. Cytotoxic T cells (CTL) protect us against intracellular pathogens and cancer by killing infected and cancerous cells. It has been believed that CTL operate on two different time scales of killing by releasing soluble cytotoxic proteins from dense core granules into the immunological synapse between the T cell and target cells (seconds/minutes) and by FasL-mediated apoptosis (hours/days). Members of the ATTACK consortium have independent observations that converge on a previously unknown weapon in the T cell tactical arsenal: stable supramolecular attack particles (SMAPs) that kill target cells (hours). This raises the possibility to engineer these particles to operate independent of T cells. Baldari has discovered that intraflagellar transport proteins sort cytotoxic proteins within the CTL. Rettig has revealed a new storage depot in CTL called a multicore granule that is distinct from the dense core granule. Dustin uncovered that CTL release SMAPs into the immunological synapse to kill targets. Valitutti has called attention to active resistance of tumour cells to synaptic attack, highlighting the strategic advantage of a non-synaptic attack. The consortium has expertise in mouse models, gene editing in primary T cells, super-resolution and live cell microscopy, and microfluidics. The goal of the ATTACK consortium will be to work closely together through 4 work-packages to determine 1) how SMAPs are made, 2) how they are released, 3) how they work and 4) how cancer cells respond. The consortium will integrate all it learns to develop the biotechnology of SMAP enhancement in engineered T cells, recombinant SMAPs, and synthetic SMAPs. We envision that SMAPs will be freeze-dried and shipped around the world, solving problems related to current immunotherapies, leading to global health impact.

Keywords: immunological synapse,cytotoxic t lymphocytes,cytotoxic granule biogenesis,trafficking and fusion
GENIE: GeoEngineering and NegatIve Emissions pathways in Europe (GENIE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Austria,Germany,United States,Denmark
Call: ERC Synergy Grant (ERC-2020-SyG, 2020)
Start date: 2021-05-01
End date: 2027-04-30
Duration (months): 72.0
Total project cost (EUR): 9187901.75
EU funding (EUR): 9187901.75
Participants: 4
Project status: SIGNED

Geoengineering technologies, such as solar radiation management (SRM), and negative emissions technologies, such as greenhouse gas removal (GGR), are emerging options to address climate change. This project will investigate the environmental, technical, social, legal, and policy dimensions of GGR and SRM. We provide an urgently needed interdisciplinary and holistic perspective of these technologies in order to understand conditions under which they might be deployed at scale. Our meta-analytical framework integrates insights from social science, engineering and physical science disciplines to provide a comprehensive view of GGR and SRM in the transition to climate neutrality in Europe and the world. The project will conduct excellent research and generate a robust, scientific assessment for evidence-based policymaking. Our research framework consists of three pillars—techno-economic systems, socio-technical systems, and systems of political action—within which we place six work packages (WPs). These are: (1) Understanding the current state and future potential of GGR and SRM technologies in terms of their technical and economic features; (2) Analysing bottlenecks in transitions to climate neutrality and their implications for deployment; (3) Identifying social acceptance and legitimacy constraints, (4) Learning, diffusion, and adoption; (5) Implications for Sustainable Development Goals of archetypical mitigation pathways; and 6) Policy options and governance. A crosscutting WP7 synthesizes research along three salient, but under-researched themes: A) Socio-technical change; B) Managing transition risks; and C) Political economy and feasibility of deployment. WP8 focuses on stakeholder engagement, entailing scenario co-design, science-policy dialogue formats, and specific outreach formats for target groups.

Keywords: negative emissions,geo engineering,solar radiation management,carbon dioxide removal,climate policy,energy policy
Photo Thermal Management Materials (PHOTHERM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain,Spain,Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-02-01
End date: 2027-01-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 1359068.22
Participants: 3
Project status: SIGNED

Since the beginning of civilization, humanity has built houses to sustain comfortable living conditions throughout the seasons. In our modern society, about 50% of the total energy consumption is used for heating and cooling. Growing demands for thermal management in many different sectors, from electronics to housing, inevitably means increased energy consumption. The primary source of heat is coming from the combustion of fossil, bio, or waste-based feedstocks, all contributing to emissions. This project seeks to fundamentally change how we generate heating and cooling by developing a new class of materials that capture, store, and release both solar and ambient heat. The solar thermal management materials are a unique combination of molecular photo-switches that capture and store sunlight, so-called MOST systems, together with phase change materials (PCM) that can contribute to thermal management. The two classes of materials operate at fundamentally different principles. The input of MOST system is photons, whereas the output is heat. The PCM materials can absorb heat from the environment. By combining the two materials into one, we can harness and upgrade two of the most abundant renewable sources of energy on the planet: ambient heat and sunlight. The materials function will be demonstrated in heat to power devices that can operate 24/7 without the need for traditional batteries. The MOST-PCM combination has the potential to disrupt how we control the temperature in a broad range of applications, from local power production to heating and cooling in electronics systems, to temperature control in automotive and housing. The materials developed in this project have the potential to radically change thermal comfort and energy consumption and give new design opportunities to thermal management systems from the 10-9 to 10 m length scale.

Keywords: molecular photoswitches
Managing Automated Vehicles Enhances Network (MAVEN)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Belgium,Czechia,Netherlands,Netherlands,United Kingdom
Call: Safe and connected automation in road transport (H2020-MG-2015_TwoStages, 2015)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 3149661.25
EU funding (EUR): 3149661.25
Participants: 12
Project status: CLOSED

Highly automated vehicles and cooperative ITS technology will get more and more present in the near future. By combining both, guidance of (groups of) such vehicles can considerably improve especially in urban areas. For management of automated vehicles at signalized intersection and corridors, the MAVEN (Managing Automated Vehicles Enhances Network) project will develop infrastructure-assisted platoon organization and negotiation algorithms. These extend and connect vehicle systems for trajectory and maneuver planning and infrastructure systems for adaptive traffic light optimization. Traffic lights adapting their signal timing to facilitate the movement of organized platoons and reversely will yield substantial better utilization of infrastructure capacity, reduction of vehicle delay and reduction of emission. The MAVEN project will build a system prototype for both field tests and extensive modeling for impact assessment, contribute to the development of enabling technologies such as communication standards and high-precision maps, and develop ADAS techniques for inclusion of vulnerable road users. Additionally, MAVEN will include a user assessment and the development of a roadmap for the introduction of vehicle-road automation to support road authorities in understanding changes in their role and the tasks of traffic management systems. Finally, MAVEN will white paper on ‘management of automated vehicles in a smart city environment’ will be written to position the MAVEN results in the broader perspective of passenger transport in smart / future cities and to embed them with smart city principles and technologies as well as service delivery.

Keywords: adaptive traffic light,platoon organization,negotiation algorithms,trajectory and manoeuvre planning
Innovative PET scanner for dynamic imaging (4D-PET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Spain,Switzerland
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-01-01
End date: 2023-12-31
Duration (months): 84.0
Total project cost (EUR): 2048386.0
EU funding (EUR): 1923386.0
Participants: 2
Project status: SIGNED

The main objective of 4D-PET is to develop an innovative whole-body PET scanner based in a new detector concept that stores 3D position and time of every single gamma interaction with unprecedented resolution. The combination of scanner geometrical design and high timing resolution will enable developing a full sequence of all gamma-ray interactions inside the scanner, including Compton interactions, like in a 3D movie. 4D-PET fully exploits Time Of Flight (TOF) information to obtain a better image quality and to increase scanner sensitivity, through the inclusion in the image formation of all Compton events occurring inside the detector, which are always rejected in state-of-the-art PET scanners. The new PET design will radically improve state-of-the-art PET performance features, overcoming limitations of current PET technology and opening up new diagnostic venues and very valuable physiological information

Keywords: compton
STI International Cooperation Network for Eastern Partnership Countries – PLUS (EaP PLUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Coordination and support actions
Countries involved: Azerbaijan,Armenia,Ukraine,Austria,Germany,Moldova, Republic of,Greece,Poland,Belarus,Belgium,Hungary,Greece,Georgia,France,Portugal
Call: Encouraging the research and innovation cooperation between the Union and selected regional partners – proposals targeting Southern Mediterranean Neighbourhood, Eastern Partnership (H2020-INT-INCO-2015, 2015)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 1569078.75
EU funding (EUR): 1569078.75
Participants: 18
Project status: CLOSED

The project 'STI International Cooperation Network for EaP Countries Plus (EaP PLUS)' aims to stimulate cooperation between researchers from the EaP countries and EU MS and enhance the active participation of the Eastern Partnership countries in Horizon 2020 Framework Programme. Building on the results of the predecessor FP7 project 'IncoNet EaP', the project will eliminate remaining obstacles to EU-EaP STI cooperation through a number of innovative and targeted actions: (a) strategic priority setting through supporting EU-EaP policy dialogue and through maximizing the impact of the association to Horizon 2020; (b) stronger interaction between researchers & participation in H2020, i.e. Info days, cooperation with scientific diaspora, and grants for networking; (c) promotion of the research-innovation interface supporting communities of excellence, i.e. co-patenting analyses, clustering schemes, promotion of the technology platforms concept to EaP countries; (d) optimal framework conditions and increasing coordination in policies and programmes through training seminars for STI policymakers, increased coordination and synergies between policies and programmes of EU/MS and EaP, i.e. JPIs, COST, national programmes; (e) communication and outreach through innovative actions

Keywords: eastern partnership,research and innovation cooperation,policy dialogue,horizon 2020 participation,interaction among researchers,grants for networking,clusters,technology platforms
Encouraging INNOvation for development of GREEN jobs (INNO GREEN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Austria,Slovenia,Bosnia and Herzegovina
Call: Peer learning of innovation agencies (H2020-INNOSUP-05-2016-2017, 2017)
Start date: 2017-10-01
End date: 2018-09-30
Duration (months): 12.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

The objective of the INNO GREEN is to boost joint collaboration between the innovation support agencies through peer learning, raise their competences in offering practical and innovative tools as a support to SMEs in innovative “green” entrepreneurship. The “Twinning advanced” methodology will be used as a basis for development of joint learning process between the project partners and increase of their competences in provision of efficient support to SMEs in “green” entrepreneurship. This project will focus to upgrade existing competences and practices of innovation support agencies and develop innovative coaching/mentoring or other kinds of suitable programs in support of SMEs on their path to generation and development of green jobs. The special attention of the project will be focused to implementation of the pilot actions on green entrepreneurship in order to test the programs prepared: assessment of green jobs potential, interviews of SMEs, bottom-up work with “green” entrepreneurs, workshops, knowledge exchange, adaptation to local context and transfer of practical knowledge from one region to another, coaching/mentoring for specific skills related to “green” employment. The final result of the project will be the Design Option Paper (DOP) to serve as a practical guide for design and implementing of coaching/mentoring for SMEs on green entrepreneurship. The DOP will address the development of an innovative program to support SMEs on their path to generation of “green” jobs.

Keywords: innovation,green jobs,green entrepreneurship,pilot action,collaboration,peer learning,competences,practical tool,twinning advanced,learning process,coaching,mentoring,design option paper
Innovative fuel cell propulsion technology enabling long endurance for small UAVs (UAVEndure II)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany,Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-12-01
End date: 2022-05-31
Duration (months): 30.0
Total project cost (EUR): 3551250.0
EU funding (EUR): 2485875.0
Participants: 2
Project status: SIGNED

UAV flight time is critical for several mission scenarios, as frequent recharging or refuelling limits the effective availability and service time, as well as range. This has thus far prevented the use of fully electric unmanned aerial vehicles (UAVs), since their performance scales unfavourably with the size/intensity of the UAV operation. Moreover, when small electric UAVs are massively deployed, and particularly in time critical mission, the handling and charging of many battery packs becomes a logistical problem. Thus, manned aerial platforms (helicopters and planes) or large (>25 kg) fixed-wing UAV systems, powered by internal combustion engines (ICE) have been the preferred option for long endurance missions such as monitoring and surveying. However, these large systems present high CAPEX and OPEX, mostly due to the oversized nature of these systems. The unique approach of UAVEndure II project is the combination of two technologies, namely small fixed-wing UAVs and fuel-cell power generation at a downsized scale and price not attempted before. The rationale is to harvest all the benefits of small electric UAVs, while having access to high endurance hitherto only possible with large aerial platforms propelled by ICE. Sky-Watch (SKY) and KraftWerk (KWT) have jointly developed the next generation fuel cell propulsion system for small UAVs - ELJUN - to cover the needs of drone OEMs and end-users for increased flight range/time of small UAVs. ELJUN provides 10x more flight range than LiPO battery. This is expected to further increase the usability of these small systems as an alternative to larger, costlier drones, thus untapping wider access to the use of this technology in civil and governmental applications. Thus, we expect ELJUN to become a new reference in the sector.

Keywords: fuel cell,drone,fixed wing,transitional,unmanned aerial vehicles uav
Unravelling mechanisms controlling asperities synchronization and triggering mega-earthquakes: insights from analog experiments and subduction zone earthquake statistics (AspSync)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Subduction mega-earthquakes are among the most destructive events on Earth. When affecting very densely populated areas these earthquakes may cause extensive human losses and severe damages, as for the 2011 M9.0 Tohoku-Oki event (Japan). According to the ‘asperity model’, a mega-earthquake may occur when regions of the fault that are potentially seismic (i.e., asperities) interact and synchronize failing together. But understanding the physical conditions that are responsible for such synchronization still remains enigmatic. AspSync proposes to tackle this problem using a multidisciplinary approach that combines analog modelling with geodynamics and statistics. AspSync proposes to develop a 3D mechanical prototype that reproduces the convergent margin features, including interplate earthquakes. This model will feature laterally (i.e., in trench parallel direction) heterogeneous frictional behavior mimicking the asperities that characterize the plate interface. Tuning the physical and frictional properties of asperities, AspSync will systematically test the role of their dimensions, distance, geometry and strength in the synchronization process, unlocking the possibility to infer the physical conditions that lead to the triggering of mega-earthquakes. AspSync will then link the experimental results with ‘real Earth conditions’, studying the feedbacks between geodynamical properties of convergent margins and interplate seismicity aiming to identify the physical conditions that promote mega-earthquakes triggering. AspSync will update and analyze the existing database of global physical properties of subduction zones and interplate seismicity developed at UM2 applying robust statistics (e.g., multi-parametric pattern recognition analysis; analysis of temporal series) to quantitatively estimate cause-effect relationships between geodynamical and seismic parameters.

Keywords: subduction mega earthquakes,seismic asperities,laboratory models