Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Peptide-derived bioavailable macrocycles as inhibitors of protein-RNA and protein-protein interactions (PEP-PRO-RNA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-03-01
End date: 2021-08-31
Duration (months): 66.0
Total project cost (EUR): 1499268.75
EU funding (EUR): 1499268.75
Participants: 1
Project status: CLOSED

The objective of this proposal is the elucidation of general principles for the design of bioavailable peptide-derived macrocyclic compounds and their use for the development of inhibitors of protein‒protein (PPI) and protein‒RNA interactions (PRI). Over the last decade, drug discovery faced the problem of decreasing success rates which is mainly caused by the fact that numerous novel biological targets are reluctant to classic small molecule modulation. In particular, that holds true for PPIs and PRIs. Approaches that allow the modulation of these interactions provide access to therapeutic agents targeting crucial biological processes that have been considered undruggable so far. Herein, I propose the use of irregularly structured peptide binding epitopes as starting point for the design of bioactive macrocycles. In a two-step process high target affinity and bioavailability are installed: 1) Peptide macrocyclization for the stabilization of the irregular bioactive secondary structure 2) Evolution of the cyclic peptide into a bioavailable macrocyclic compound Using a well-characterized model system developed in my lab, initial design principles will be elucidated. These principles are subsequently used and refined for the development of macrocyclic PPI and PRI inhibitors. The protein‒protein and protein‒RNA complexes selected as targets are of therapeutic interest and corresponding inhibitors hold the potential to be pursued in subsequent drug discovery campaigns.

Keywords: peptidomimetic,protein protein interaction,protein rna interaction
Identification of a Metalloproteinase-17-mediated cellular signalling circuit in intestinal regeneration and tumorigenesis (MetalloGutRepair)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 196400.4
EU funding (EUR): 196400.4
Participants: 1
Project status: CLOSED

The digestive tract has been assigned important but complex tasks. It provides our body with nutrients and water. It gets rid of pathogens while allowing the commensal flora to thrive, and it quickly repairs injuries caused by the constant mechanical and biological stress. Lgr5+ intestinal stem cells (ISCs) play a crucial role in these processes, but when ISCs are lost due to injury, differentiating cells must ‘de-differentiate’ into ISCs to regain the stem cell pool. The cellular signalling processes that control these repair processes are still largely unknown. Matrix metalloproteinases (MMPs) are enzymes capable of cleaving both matrix and non-matrix proteins. My preliminary data identifies Mmp17 as a crucial regulator of inflammation-induced intestinal regeneration. Notably, Mmp17 is only expressed in a subpopulation of visceral smooth muscle cells, and thus is absent from the epithelium. I hypothesize that Mmp17+ cells provide essential niche factors for repair. In addition, I propose that Mmp17 plays an important role in tumorigenesis. First, I will test the role of Mmp17 in intestinal regeneration after whole-body irradiation. My in vivo studies will be supported by an original ex vivo co-culture model, where I combine organoids and muscle cells. Next, I will test the role of Mmp17 in an established tumorigenesis model. Finally, I will attempt to identify the responsible substrate that mediates these processes, both by unbiased mass spectrometry experiments, and by focusing on likely candidates. This work will reveal a new role for muscle cells in the repair of the intestinal epithelium, and may have important implications for treating inflammation, infections and gastrointestinal cancers. MetalloGutRepair thus combines my expertise in smooth muscle cells with that of the host lab in intestinal disease models, in a research environment where I will reach my immediate goals while developing crucial skills for my long-term career as an independent researcher.

Keywords: regeneration,matrix metalloproteinases,inflammation,intestinal smooth muscle,autocrine signaling,stem cell niche
ERIC Forum Implementation project (ERIC Forum)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Coordination and support actions
Countries involved: Germany,Spain,Spain,Germany,Germany,Germany,Spain,Italy,Italy,Italy,Austria,Norway,Sweden,Norway,Finland,Finland,France,France,Czechia,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Policy and international cooperation measures for research infrastructures (H2020-INFRASUPP-2018-1, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 1495281.25
EU funding (EUR): 1495281.25
Participants: 31
Project status: CLOSED

ERIC – European Research Infrastructure Consortium – is a European legal instrument specifically created for European multi-side and multi-country owned Research Infrastructures (RI) in 2009. Since then 18 ERICs have been created in almost all different scientific domains. The European Commission (EC) had initiated an informal networking event, twice a year, where Managers of existing ERICs and scientists of future RI who want to use the ERIC instrument can discuss shared challenges and meet also national policy makers establishing a platform for exchange of solutions and best practises. With the H2020 call “INFRASUPP-01-2018-2019 Policy and international cooperation measures for research infrastructures” the EC is willing to fund a project for more formal and structural collaboration and coordination of ERICs. This project is set up by all existing ERICs and those consortia, which have at least submitted their Stage-1 application to implement the objectives of the call: • aim at strengthening coordination and networking reinforcing the informal ERIC network or its successor framework; • support the organisation of specific meetings, targeted thematic workshops focussing on shared challenges such as the development of internal procurement rules, harmonised reporting, VAT exemption practices, insurances and pensions policies and training of governance bodies representatives; • support ERICs in preparation, based on best practices; • support common communication and outreach activities and strengthening external representation of ERICs' as a stakeholder in consultations and other policy actions that could affect them.

Keywords: eric,research infrastructures
Indigenous Language, History and Culture: Politics, Writing and the Decolonization of Knowledge amongst the Maya in Chiapas, Mexico, 1970-2015 (INDILANGHISTCULT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

In the 1980s, in a context of growing indigenous political activism, the Maya in Chiapas began to write and publish their own history in their own languages for the first time since the conquest. Just a few years before, Maya hieroglyphic writing – the last ancient script to be deciphered by modern scholars – was decoded as a logo-phonetic writing system with significant similarities to present-day Maya languages. These intellectual innovations have opened the door to the development of new understandings of the Maya past and present and the decolonization of knowledge produced by and about Maya peoples. This project aims to develop new interpretations of contemporary Maya historical narratives in Chiapas by using the most recent scholarship on ancient Maya writing and literacy to analyze a selection of texts produced in Maya languages in Chiapas since the 1980s, and to consider how innovations in scientific understandings of the ancient Maya have impacted upon contemporary Maya historians and writers. It also aims to use qualitative interviewing methods in order to understand: first, the relationship between bi-lingual education, the development of new Maya historiographies, and political activism from the 1970s; and second, how the use of digital media by indigenous people in Chiapas has revolutionized communication, consciousness and inclusion amongst a new generation of Maya in the last 10-15 years. It will bring together modern historical and social science research perspectives and methods, archaeological, epigraphic and linguistic expertise, indigenous cultural and historical knowledge and technological awareness to develop new understandings of Chiapas's Maya peoples, and will thus constitute an original, innovative and cross-disciplinary contribution to studies of history, communication and consciousness amongst indigenous peoples in Mesoamerica and beyond.

Keywords: mexico,chiapas,indigenous peoples,maya,mesoamerican history,indigenous social and political movements,maya languages and epigraphy
Found in Translation – Natural Language Understanding with Cross-Lingual Grounding (FoTran)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Finland
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-09-01
End date: 2024-02-29
Duration (months): 66.0
Total project cost (EUR): 1817622.0
EU funding (EUR): 1817622.0
Participants: 1
Project status: SIGNED

Natural language understanding is the "holy grail" of computational linguistics and a long-term goal in research on artificial intelligence. Understanding human communication is difficult due to the various ambiguities in natural languages and the wide range of contextual dependencies required to resolve them. Discovering the semantics behind language input is necessary for proper interpretation in interactive tools, which requires an abstraction from language-specific forms to language-independent meaning representations. With this project, I propose a line of research that will focus on the development of novel data-driven models that can learn such meaning representations from indirect supervision provided by human translations covering a substantial proportion of the linguistic diversity in the world. A guiding principle is cross-lingual grounding, the effect of resolving ambiguities through translation. The beauty of that idea is the use of naturally occurring data instead of artificially created resources and costly manual annotations. The framework is based on deep learning and neural machine translation and my hypothesis is that training on increasing amounts of linguistically diverse data improves the abstractions found by the model. Eventually, this will lead to universal sentence-level meaning representations and we will test our ideas with multilingual machine translation and tasks that require semantic reasoning and inference.

Keywords: computational linguistics,distributional semantics,representation learning,machine translation,deep learning,artificial neural networks
Complete Dynamic Multi-cloud Application Management (CYCLONE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Innovation actions
Countries involved: Germany,Germany,Spain,Italy,Switzerland,France,Netherlands
Call: Advanced Cloud Infrastructures and Services (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 3843602.0
EU funding (EUR): 2846402.0
Participants: 7
Project status: CLOSED

Application service providers (ASPs) now develop, deploy, and maintain complex computing platforms within multiple cloud infrastructures to improve resilience, responsiveness and elasticity of their applications. The CYCLONE project targets the ASPs, providing them with software and tools that 1) facilitate the deployment, management, and use of their complex, multi-cloud applications and 2) enhance the end-to-end security and network management of those applications. Using agile methodologies and continuous delivery, CYCLONE integrates and improves mature, open-source components, such as StratusLab, OpennNaaS, SlipStream, and TCTP. Participants from the bioinformatics and energy sectors will guide the initial platform development; use cases from additional sectors identified during the project will drive its subsequent evolution. Constant availability of the CYCLONE testbed allows all these users to rapidly prototype their complex cloud applications and to provide continuous feedback to the developers, thus validating the CYCLONE software’s design, implementation, and production quality. CYCLONE allows ASPs to aggregate resources from multiple cloud providers (private and public) to improve the reliability of their applications through geographic redundancy, to enhance the user experience by placing services (and data) near their users, to lower barriers between cloud providers via a cloud deployment engine with appropriate resource abstractions, and to tailor intra- and inter-site networking resources. Coupled with application-level security features and trust bootstrapping mechanisms, CYCLONE allows ASPs to define their own innovative and secure cloud platform tailored to their needs and trusted by their users.

Keywords: cloud brokering authentication security networking multi cloud application service provider agile scrum continuous delivery federation aggregation bioinformatics energy iaas paas saas naas
2014-2015 Researchers' Night: The Greek events (ReN2014-15)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Greece,Greece,Greece,Greece,Greece
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-06-01
End date: 2015-11-30
Duration (months): 18.0
Total project cost (EUR): 219812.5
EU funding (EUR): 205413.0
Participants: 5
Project status: CLOSED

ReN2014-5 events will be organized during 2014 and 2015 and will take place in six major cities: i) Athens, Greece’s capital, ii) Thessaloniki, iii) Patras, iv) Heraklion, v) Volos and for the first time in vi) Corfu, the capital of the Ionian Islands. These cities are spread almost nation-wide and cover more than two-thirds of Greece’s total population ensuring a first-hand experience of ReN2014-5 activities from a large audience. The consortium consists of prestigious universities and research centres which over the years have built extended networks that ensure maximum visibility of the events. TV, Radio spots and interviews of highly-profiled researchers are foreseen, at national level, spreading the messages throughout the country while, at local level, apart from traditional communication ways of promotions, other innovative ones, such as the “taxi of researcher” will be used to provoke the curiosity of local communities. The awareness campaign will target the general public however special focus will be given on University students by explaining the benefits of the researcher’s profession thus playing a small but not insignificant role to the realization of the Horizon 2020 which calls out for more researchers within Europe. The events will be organized, mainly, in central places of the cities and will give the possibility of interaction between the public and the researchers throughout various activities which will be related to the problems of the local community and the solutions that researchers are able to provide, thus intriguing the public’s interest. Iit is estimated, conservatively, that ReN2014-5 messages will reach at least one million people nation-wide while more than 20.000 people will actually participate in the events each year. The impact of the events will be measured using quantitative data from questionnaires, number of participants and qualitative data such as references in media during the post-event days.

Keywords: researchers night,party,event,experiments,public,students,greece,athens,thessaloniki,heraklion,larissa,trikala,patras,corfu,2014,2015,certh,ntua,forth,upatras
EISS - Eco Innovation Support Services (EISS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Italy,Hungary,Greece
Call: peer learning of innovation agencies (H2020-INNOSUP-2014-5, 2014)
Start date: 2015-10-01
End date: 2017-03-31
Duration (months): 18.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

The aim of the project is to collaboratively address a common innovation support challenge; namely to improve eco-innovation support services in smaller manufacturing companies from traditional sectors in the peripheral regions, where innovation services offer is often weak. The most important outcome is a joint Design Option Paper, which will serve as a “guide” or a “handbook” to other agencies and business support centres to provide similar, more focused services on eco-energy efficiency.
European Magnesium Interactive Battery Community (E-MAGIC)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Germany,Israel,Spain,Germany,Spain,Spain,France,Denmark,United Kingdom
Call: FET Proactive: emerging paradigms and communities (H2020-FETPROACT-2018-01, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 6731937.5
EU funding (EUR): 6731937.5
Participants: 10
Project status: SIGNED

Energy storage is a key technology to facilitate a widespread integraWith the growing use of intermittent energy sources in power grids, there is a growing mismatch between when energy is produced and when it is consumed. This has led to the need of energy storage or demand-response systems in order to use the energy in a balanced and efficient way. Given this context, the Micro Energy Storage (MES) systems are expected to seek radically new approaches to supply energy where it is needed. Buildings are becoming a local use micro energy-hubs consuming, producing, storing, supplying energy and having the potential to take up an important role in the power-supply system stability which generate energy with renewables, provide storage for electric and thermal energy and deliver demand response. For Micro Energy Storage in Buildings (MESB) using stochastic renewables energy, the most suitable technology is the lithium-ion batteries (LIB). However, current LIB technologies are facing severe challenges in safety, energy density and price. While most of today's R&D is concentrated on LIB systems, shifting towards non-lithium rechargeable batteries may open up effective ways to overcome such challenges. The rechargeable magnesium battery (RMB) constitutes a paradigmatic example of such promising, alternative non-lithium energy storage systems, following pioneering efforts and breakthroughs from world-wide researchers. The potential to use metallic magnesium anodes in rechargeable batteries brings important advantages in terms of energy density, cost and safety. E-MAGIC gathers the key scientific and technical researchers in Europe to develop the required new frontier knowledge and foundational approaches on RMB, bringing an effective work on R&D by a rational design of high voltage/high capacity cathode materials and novel electrolytes to overcome the rate-limiting reaction and transport processes, in order to deliver a safe RMB with more 400 Wh kg-1 and less than 100 €/Kwh.

Keywords: high energy density,magnesium batteries,non lithium batteries,micro energy storage
Combating 2019-nCoV: Advanced Nanobiosensing platforms for POC global diagnostics and surveillance (CoNVat)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,France
Call: Advancing knowledge for the clinical and public health response to the 2019-nCoV epidemic (H2020-SC1-PHE-CORONAVIRUS-2020, 2020)
Start date: 2020-03-10
End date: 2022-09-09
Duration (months): 30.0
Total project cost (EUR): 2547152.48
EU funding (EUR): 2547152.48
Participants: 5
Project status: CLOSED

The recent outbreak in China caused by the emerging nCoV virus is challenging the level of global readiness from governments, public organizations and community to face and manage both its social and health consequences. Once the emergence is recognized and identified, it is crucial to initiate the necessary measures to prevent the spread. This involves therapeutics, vaccines, and devising efficient, fast, readily accessible diagnostics methods that specifically confirm the presence of the virus. Early detection can allow the rapid implementation of containment measures, which are the key to reduce the risk of amplification. The aim of CoNVat is to implement a Point-of-care label free biosensor for the direct, fast and specific identification of nCoV in decentralized settings to improve its early diagnosis and the clinical management of patients. The approach employs an already developed technology based on nanophotonic bimodal waveguide (BiMW) interferometers capable of providing real time, highly sensitive detections assays in short sample turnaround times. We propose two different strategies: (i) the development of a fast antigen-based diagnostic test for the specific detection of the intact virus in patient’s samples such as respiratory specimens and non-respiratory fluids (serum, urine…) to be deployed to clinical settings for initial screening and (ii) development of a multiplexed molecular test, PCR-free, for the reliable identification of nCoV, being possible to differentiate the type and strain of coronavirus form other related or more common respiratory viruses. This latter strategy will provide a disruptive diagnostic tool not only from a clinical perspective to improve patient’s outcome but also for surveillance, to study and understand possible transmission routes of this virus by analysing samples from animal reservoirs. Final prototype validation will demonstrate the potential of this approach for the management of future infectious outbreaks.

Keywords: point of care,early diagnostics,photonic biosensor,antigen test,molecular test,pcr free,label free,real time,environmental screening,animal reservoirs