Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative Imaging Insights (I3): Development of MR-compatible Bioreactors for Tissue Engineered Heart Valves (I3)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: SIGNED

Given the escalating global burden of valvular heart disease and the pressing need for living heart valve replacements, I decided to focus my research on this healthcare challenge by acquiring new skills through advanced training and international interdisciplinary collaborations. My proposal I3 combines the design and application of a novel bioreactor for assessing tissue engineered heart valves (TEHVs) by highly advanced magnetic resonance imaging (MRI) to kickstart the innovation cycle in in-vitro experiments. Especially young patients with valvular heart disease will profit from TEHVs as they suffer from current heart valve replacements lacking the ability to self-repair and growth as well requiring the life-long intake of anticoagulants. Leveraging the high-dimensional, non-invasive analysis potential of MRI, my I3 proposal establishes new innovative tools for TEHV research to enable new insights in the resulting hemodynamics downstream of TEHVs, close the optimization loop in-vitro using patient-specific boundary conditions and reduce the need for ethically and monetary challenging animal experiments. Building on my expertise on advanced MRI, I will acquire new skills to develop a novel MRI-compatible bioreactor in the project. Enabling in-vitro experiments with high precision and repeatability, the imaged flow field in the bioreactor allows me to select and optimize a TEHV for specific hemodynamics of patients. In-vivo MRI-enabled feedback of the resulting hemodynamics offers further diagnosis. Furthermore, in-vitro and in-vivo measurements offer important information for optimization of TEHVs for patient-specific treatments. I will use the knowledge and skills gained from this inter-sectoral and inter-disciplinary project for my next career steps (incl. submission of an ERC starting grant) in the field of biomedical engineering research aimed at providing all patients with a suitable heart valve replacement. I3 is a major step towards making this a reality.

Keywords: cardiovascular imaging,tissue engineered heart valves,congentinal heart disease,mri flow imaging,pc mri,patient specific,real world problems,sdg 3 4,optimization,bioreactors,biomimetics
Tunable Nanoengineered Transition Metal Dichalcogenides for Quantum Nanophotonics (TuneTMD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1499578.0
EU funding (EUR): 1499578.0
Participants: 1
Project status: SIGNED

In optical quantum computing, qubits are encoded on single indistinguishable photons emitted by single-photon sources (SPSs). The computation is carried out by interfering single photons and by measuring the output using single-photon detectors. A scalable optical quantum computer requires many individual SPSs emitting indistinguishable single photons, however, different SPSs emit light at slightly different wavelengths due to fabrication imperfections. This issue can be resolved by implementing an active control for each SPS to ensure generation of completely identical photons. Despite recent progress, active control of individual SPSs still remains one of the biggest challenges in future quantum technologies. Moreover, the vision of constructing an on-chip platform by integrating SPSs, waveguides, and detectors into a single planar chip is challenging due to the complicated integration of the conventional material platforms. The TuneTMD project aims at developing a tunable on-chip integrated optical circuit using fully nanoengineered mono- and multilayer transition metal dichalcogenides (TMDs), and performing Hong-Ou-Mandel experiments on-chip. I hypothesize that unique optical and physical properties of multilayer TMDs such as high refractive index, low loss at telecom range, active tuning capability, and easy integration between different types of TMDs, combined with optimized nanopatterning techniques make nanoengineered TMDs the ideal semiconductor platform to build tunable, on-chip, fully integrated quantum optical circuits. I will exploit my expertise in nanophotonics and 2D materials to fabricate novel TMD photonic devices, e.g. SPS, waveguide, beamsplitter, and detector. Then I will integrate them on a chip to construct fully integrated quantum optical circuits. Finally, to demonstrate the ground-breaking nature of the proposed platform, I will perform a Hong-Ou-Mandel experiment with two tunable sources.

Keywords: single photon source,two dimensional materials,tmd nanophotonics,quantum optics,on chip quantum photonic circuits
Masters of the stone: The stonecutters' workshops and the rise of the late antique epigraphical cultures (third-fifth century AD) (STONE-MASTERS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Poland
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1499625.0
EU funding (EUR): 1499625.0
Participants: 1
Project status: SIGNED

The STONE-MASTERS project aims at exploring one of the most startling problems in the global history of research on collective memory and commemorative practices - the transformation of Roman Imperial epigraphic traditions in the later 3rd c. AD, and the subsequent rise of the so-called epigraphic cultures of Late Antiquity. The problem has been passionately debated since the 1980s, but so far no definite conclusions have been reached. In this project, the PI argues that the main reason for the transformation is to be ascribed to the dissemination of changes in the elite's approach to epigraphy by the workshops of stonecutters and mosaicists, and that only a thorough study of workshops can provide us with a complete understanding of the processes underpinning this same transition. So far, epigraphists of the Roman period have had few instruments to draw upon for the purposes of pursuing synthetic workshop studies, and have been overwhelmingly captivated by other strands: the quantitative research, the study of the self-representation, the visibility of inscriptions, and the "viewers' culture". The PI maintains that a significant leap in our understanding is, however, attainable through the building of a highly regionalized network/stemma of workshops, which will identify workshops of origin for all the inscriptions from the 3rd-5th c., and through applying the methodologies of workshop studies developed for other craftsmanships and periods (in particular for early Greek vase painters, and for scribes and scriptoria) which the PI will adapt to the needs of the Graeco-Roman epigraphy. Assuming that these new methodological lenses will redefine the field and re-focus our attention on the actual actors behind the production of epigraphy - artisans and workshops - as primary agents of top-to-bottom cultural transfer, then we can anticipate an entire restructuring of our understanding of the way artisans disseminated elitist culture in the lower echelons of society.

Keywords: greek epigraphy,latin epigraphy,epigraphic habit,workshops,quarries,stonecutters,mosaicists,late antiquity,early byzantine period
Stable Optimized Layered Inorganic/organic Devices (SOLID)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-19
End date: 2028-01-18
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: SIGNED

The SOLID (Stable Optimized Layered Inorganic/organic Devices) project aims to advance Layered Metal Halides (LMHs) in photovoltaic technology, addressing the European Green Deal’s priorities for clean energy innovation. The project focuses on developing LMHs with polyaromatic organic ligands that enhance π-stacking interactions in a manner to increase charge mobility within the new materials, targeting power conversion efficiencies above 20%. Key objectives include synthesizing LMHs with at least a 10% increase in charge carrier mobility, optimizing thin-film deposition techniques for vertically oriented sub-lattices, identifying compositions with reduced trap states and optimal bandgaps, and achieving less than 10% degradation in performance after 1,000 hours under standard conditions. By overcoming stability and efficiency challenges in perovskite solar cells, SOLID will set new benchmarks for scalable, high-performance photovoltaic materials. The project will have broad scientific impacts, advancing knowledge in materials science and influencing future research and technology development. It will also contribute to societal goals by enhancing renewable energy adoption, reducing greenhouse gas emissions, and supporting the transition to a sustainable energy future. The project integrates environmental sustainability, including resource-efficient lab practices and the exploration of greener materials. Career development is central, with training in advanced characterization methods, sustainable research practices, and project management under the mentorship of experts at ICIQ. This experience will prepare the researcher to lead in renewable energy innovation, directly supporting the EU’s climate and sustainability targets.

Keywords: layered metal halides,perovskite solar cells,photovoltaic technology,polyaromatic ligands,stacking,renewable energy,stability,efficiency,advanced materials,clean energy
On-Demand Bioresorbable OptoElectronic System for In-Vivo and In-Situ Monitoring of Chemotherapeutic Drugs (RESORB)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,France,Portugal
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-04-01
End date: 2025-09-30
Duration (months): 42.0
Total project cost (EUR): 2606250.0
EU funding (EUR): 2606250.0
Participants: 7
Project status: SIGNED

We envision a radically new technology for in-vivo bioresorbable chemical sensing, where optical devices, power and light sources, synthetic receptors - made out of materials that completely dissolve with biologically benign byproducts in biofluids - will be developed and integrated together. The sensing system, the size of 1 EuroCent, will be coated by a long-lived biocompatible polymer designed with on-demand degradation, then implanted in the body to monitor in-vivo, in-situ, and in real-time a chemotherapeutic drug, doxorubicin, commonly used to treat cancer; the system is then fully and safely RESORBed once no more needed using an external temperature-trigger that initiates the dissolution of the protecting coating and, in turn, of the system, avoiding device-retrieval surgery that may cause tissue lesion/infection. The general objective is to demonstrate fabrication, operation (2 months) in-vivo and in real-time - then dissolution - of such a bioresorbable chemical sensing system for the detection of doxorubicin in an animal model. This will break a new ground in in-situ monitoring of chemotherapeutic drug enabling – for the first time – a fine tuning of the drug dose at the tumor site, increasing patient survival rate. Being aware of the project risks, we have broken down the general into different specific objectives, identified a set of Key Performance Indicators, alternative material synthesis/device fabrication techniques, mitigation measures to tackle major risks. The RESORB technology truly represents the foundation of a future technology for personalized medicine, enabling to address a number of medical issues for which continuous and localized monitoring of specific analytes (i.e., biomarkers and drugs) in-vivo for a prescribed time is of chief importance, e.g., acute trauma treatment, post-surgery sepsis, drug therapeutic profiling, and other, all examples for which ex-situ analysis of biofluids has proved to be not fully adequate for clinical needs.

Keywords: cancer,chemotherapy bioresorbable electrical and optical components bioresorbable microbatteries implanted chemical sensors synthetic receptors on demand bioresorbability
Waking the Dead: Fiction and the Archival Gap in Ireland, India and the Black Atlantic (Waking the Dead)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 426533.76
EU funding (EUR): 426533.76
Participants: 2
Project status: SIGNED

Waking the Dead examines the problem of the archival gap — the impossibility of knowing much of the lives of the historically ‘unimportant’ — and asks how contemporary fiction imagines these lives anew. For decades, cutting-edge scholarship studying colonialism and its aftermath in Ireland, India and the Black Atlantic have worked on the same problem: if archives, the central object of study in mainstream historiography, only contain the written records of the powerful, then how can historians know anything substantial about the lives of the powerless? My study will expand this field of research by investigating contemporary fiction’s dynamic engagement with the archival gap, and what aesthetic, formal and thematic strategies writers employ to imagine individual lives we can know very little about. After the 2020 Black Lives Matter protests, the scholarly rekindling of interest in Saidiya Hartman’s concept of ‘Critical Fabulation’ — of imaginative embellishment of sparse archival traces — demonstrates the ongoing importance of these questions. The influential Subaltern Studies school of Indian historiography has read peasant insurgencies as evidence of a collective political consciousness otherwise lost to history. And recently in Irish Studies, there has been an interdisciplinary burst of creative methodologies studying the gender violence of the Magdalen Laundries and the Mother and Baby Homes in the absence of records withheld by the perpetrator institutions themselves. But the right to imagine, to infer, to fill in these gaps is the licence freely given to writers of fiction. This study asks what they do with this licence, and how their dynamic relationship to the archival gap probes at the very limits of historical knowledge. This will be the first interdisciplinary study of contemporary global fiction’s engagement with the archival gap and the first to connect the common projects of ‘recovery’ in Ireland, India and the Black Atlantic.

Keywords: archival gap,subaltern studies,irish studies,black atlantic,slavery,west african literature,caribbean fiction,magdalen laundries,ireland mother and baby homes
reLIable and sCalable tOols foR self-sovereIgn identity and data proteCtion framEwork (LICORICE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Innovation actions
Countries involved: France,Austria,Spain,Germany,Netherlands,Italy,Greece
Call: Privacy-preserving and identity management technologies (HORIZON-CL3-2023-CS-01, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 4642245.21
EU funding (EUR): 3999029.31
Participants: 12
Project status: SIGNED

Global accelerated digital transformation, shaped by disruptive technologies (AI and Big Data, Metaverses and Web3, etc.), brings both unprecedented opportunities for EU citizens and businesses and emerging and increased challenges: surge in sophisticated cyber-attacks, multifarious forms of data abuse and the corresponding growth of public concern over loss of data control or identity-related crimes. In this context, preserving trust among stakeholders with strong data protection guarantees is vital for digital services delivery in more secure online environments which benefit from the upcoming EU Digital Identity ecosystem and for fully developing EU data spaces for data exchange in federated computation scenarios. With its results accurately oriented towards Digital Decade’s cardinal points and target areas, fully aligned with EU’s Digital Identity and Data Strategy, directly contributing to strengthening EU’s digital and data sovereignty and also complementing outcomes from EUDI Wallet Large Scale Pilots, LICORICE Innovation Action delivers 2 highly-advanced, reliable and trustworthy self-sovereign identity and privacy-preserving toolsets (>10 tools) for user-centric, cryptographically secure identity management and verifiable federated data sharing and computing. They will align with latest EUDI Wallets specifications and data space blueprints, models and frameworks to deliver high scalability and efficiency, also featuring usability and ease-of-adoption (including by SMEs), with solid open source strategy oriented to large developer communities and boosting commercial exploitation by its industrial partners. Results will be fully validated over 2 iterations of piloting, demonstrating integration of toolset prototypes in operational environments of two high-impact pilots in domains of Cyber Threat Intelligence AI-based assistance and sharing, and eHealth services and biomedical research. LICORICE has 12 partners from 8 EU Member States and a 36-month duration

Keywords: data governance,data sovereignty,data spaces,self sovereign identity,digital sovereignty,cyber threat intelligence,ehealth
Integrated Glycomics for Cancer Precision Medicine (GlycoMap)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Norway,Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-10-31
Duration (months): 26.0
Total project cost (EUR): 226751.04
EU funding (EUR): 226751.04
Participants: 2
Project status: SIGNED

Breast Cancer is the most commonly diagnosed cancer in Europe and remains the first cause of cancer death in women (nearly 92,000 deaths in 2020). Precision medicine uses data-driven insights to reflect the heterogeneity of patients and improve cancer care by offering actionable oncology treatment options. Tumour tissue heterogeneity is the leading cause for inter-patient variation in treatment response. One of the largest sources of tissue heterogeneity arises from post-translational glycosylation of proteins and aberrant glycosylation is a hallmark of breast and other cancers. Yet, substantial gaps remain in our knowledge of cancer glycans. Glycomics (the comprehensive study of the glycome) offers the potential to provide the global glycosylation status (GlycoMap) of a patient and shed new light on tumour heterogeneity to guide precision medicine. This project aims to address the substantial knowledge gap in breast cancer tumour glycosylation data by developing an integrated glycomics workflow to produce patient-specific 'GlycoMaps'. By including glycosaminoglycan (GAG) 'omics from intact GAGs for the first time, combined with other glycan analyses will enable the generation of Breast Cancer GlycoMaps from resistant and drug-sensitive patient-derived organoids (mini avatars of tumour tissue), defining residual tumour tissue following treatment that causes relapse and metastasis. The mission and design of the GlycoMap project is to train the researcher, who has a background in GAGomics, proteoglycan biology and bioinformatics, with expanded skills and expertise in N-/O-glycomics, organoid culture, hi-resolution 3D imaging and advanced bioinformatics in the context of breast cancer, augmenting her future career opportunities, as well as establishing unbiased top-down integrated glycomics to support breast cancer analyses, diagnostics and the development of novel treatments.

Keywords: glycosaminoglycans,glycomics,glycans,breast cancer
A step towards new Plasma processing Technology for Medical purposes (PlaTechMedi)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Slovakia,Italy,Greece
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-03
End date: 2024-10-02
Duration (months): 24.0
Total project cost (EUR): 165059.52
EU funding (EUR): 165059.52
Participants: 4
Project status: CLOSED

Medical device-related infections contribute to an increase in mortality, prolongation of hospitalization and present a substantial financial burden to patients and society. Catheter-related infections are among the most common causes of healthcare-associated infections worldwide. The possibilities of low temperature plasma technologies for direct (plasma) and indirect (plasma activated water) disinfection of polymer materials will be studied. The proposed project is focused on gaining detailed insight into the plasma processing of polymer medical tubes (catheters) using Surface Dielectric Barrier Discharge with liquid electrodes. This will include the investigation of plasma-induced physical and chemical changes not only on the surface of the processed material, but also the analysis of the surrounding gas, and especially the used liquid. Examination of the discharge under specific conditions is beneficial for the understanding of the undergoing chemical and physical processes. The decontamination effect of the plasma treatment of bacteria and biofilms present on the catheter surface and in liquids will be the key objective of the project. This will be done by detailed studies of the bacterial response to reactive oxygen and nitrogen species in liquid and the biofilm growth inhibition on the polymer after the plasma treatment. The development of the plasma technology capable of polymer treatment in continuous regime and application of such plasma systems for catheters treatment will allow for a larger impact of plasma processing expanding to a wide range of new industrial applications. The obtained results will increase the quality of medical treatment, reduce the costs of specific medical care, and prolong the time between the required doctor visits for patients using different catheters. Plasma applications in medicine are leaping to become the medicine of the future, and this is my chance to contribute to its development.

Keywords: low temperature plasma,plasma liquid interactions,plasma medicine,polymer,reactive oxygen and nitrogen species,biofilm,catheters