Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Perception and Action in Complex Environments (PACE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Israel,Italy,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-04-01
End date: 2019-03-31
Duration (months): 48.0
Total project cost (EUR): 3911673.24
EU funding (EUR): 3911673.2399999998
Participants: 10
Project status: CLOSED

The PACE research and training programme sits at the interface between basic science, technology and clinics, in order to unveil how humans control and adapt their movements in complex, naturalistic environments. Such a research agenda has major consequences for understanding how these movements are impacted by specific brain insults and how these impairments can be compensated for via new rehabilitation methods. Improving rehabilitation programmes for sensory and motor disabilities across the lifespan is a major societal challenge in western countries and many obstacles need to be overcome. To provide but one example, with regard to eye-hand coordination of upper limb movement remaining abilities are rarely assessed in stroke patients or sensory-disabled children and this impacts both prognostic estimation and rehabilitation. New technologies, such as robotics or virtual reality, provide an exciting change in perspective to transfer state-of-the-art knowledge from basic research on sensorimotor transformation into the clinical domain. To meet these societal challenges, it is crucial to train a new generation of early-stage researchers in a programme such as PACE where fundamental and applied/clinical research are effectively integrated via collaborative research, doctoral secondments and theoretical courses – in other words, one in which clinicians, neuroscientists, theoreticians and engineers can contribute around a well-defined problem: how humans acquire, lose and recover movement performance. With 8 academic, 1 clinical and 1 private beneficiaries, and 5 partner organizations (4 industrial, 1 in science communication), PACE structures a training and research programme that is both highly interdisciplinary and intersectoral. Our goal is to meet both fundamental and clinical well-identified challenges as well as preparing young scientists for future european research & development in the fields of human movement studies and rehabilitation medicine.

Keywords: sensorimotor integration,naturalistic stimulation,innovative technologies for rehabilitation
Chromosome Architecture and the Fidelity of Mitosis during Development (ChromoCellDev)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Portugal
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-10-01
End date: 2021-09-30
Duration (months): 72.0
Total project cost (EUR): 1492000.0
EU funding (EUR): 1492000.0
Participants: 1
Project status: CLOSED

Genome stability relies on accurate partition of the genome during nuclear division. Proper mitosis, in turn, depends on changes in chromosome organization, such as chromosome condensation and sister chromatid cohesion. Despite the importance of these structural changes, chromatin itself has been long assumed to play a rather passive role during mitosis and chromosomes are usually compared to a “corpse at a funeral: they provide the reason for the proceedings but do not take an active part in them.” (Mazia, 1961). Recent evidence, however, suggests that chromosomes play a more active role in the process of their own segregation. The present proposal tests the “active chromosome” hypothesis by investigating how chromosome morphology influences the fidelity of mitosis. I will use innovative methods for acute protein inactivation, developed during my postdoctoral studies, to evaluate the role of two key protein complexes involved in mitotic chromosome architecture - Condensins and Cohesins. Using a multidisciplinary approach, combining acute protein inactivation, 3D-live cell imaging and quantitative methods, I propose to investigate the role of mitotic chromosomes in the fidelity of mitosis at three different levels. The first one will use novel approaches to uncover the process of mitotic chromosome assembly, which is still largely unknown. The second will explore how mitotic chromosomes take an active part in mitosis by examining how chromosome condensation and cohesion influence chromosome movement and the signalling of the surveillance mechanisms that control nuclear division. Lastly we will evaluate how mitotic errors arising from abnormal chromosome structure impact on development. We aim to evaluate, at the cellular and organism level, how the cell perceives such errors and how (indeed if) they tolerate mitotic abnormalities. By conceptually challenging the passive chromosome view this project has the potential to redefine the role of chromatin during mitosis.

Keywords: mitosis,aneuploidy,drosophila,chromosome condensation,sister chromatid cohesion,cohesin,condensin
Effectiveness and cost-effectiveness of the Initial Medication Adherence intervention: cluster randomized controlled trial and economic model (IMA-cRCT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1231075.0
EU funding (EUR): 1231075.0
Participants: 2
Project status: SIGNED

Between 3 and 42% of patients do not initiate their treatments. Non-initiation and non-adherence are associated with poorer clinical outcomes, more days of sick leave and higher costs. The aim of this research project is to generate an effective, efficient and feasible intervention that improve initiation and adherence and improves clinical symptoms. The long-term benefits in terms of improved health and reduced costs will be evaluated. The results will be disseminated to stakeholders, decision-makers and the scientific community to promote implementation. The intervention is expected to improve the clinical practice, empowering the patient. The project develops an innovative approach to the design and evaluation of behavioural interventions that uses the principles of complex interventions, pragmatic trials and implementation research. Nine interventions to reduce non-initiation have been tested. The interventions were not theory-based and most used simple reminders. The evidence supporting these interventions was low and their impact on clinical symptoms and cost-effectiveness was not assessed. The strengths of the IMA-cRCT study are: 1) the main stakeholders are involved in the design and assessment; 2) IMA intervention is theory-based and has been optimized; 3) the study will assess the impact of the intervention on clinical parameters and cost-effectiveness, which is key to guarantee its transferability; 4) the project involves decision-makers; 5) the pragmatic design increases generalisation and 6) the intervention is easily transferable to other pathologies, populations and countries. As part of the ERC research project, a pragmatic cluster randomized controlled trial (cRCT) will evaluate the short-term effects of the IMA intervention and its cost-effectiveness and Markov models will be constructed to estimate its long-term cost-effectiveness. The results will be disseminated to facilitate its transferability to clinical practice in Spain and Europe.

Keywords: non initiation,adherence,pragmatic trials,complex interventions,cost effectiveness,economic modelling,primary care,cardiovascular disease
Translating from Latin: Contacts, Transfer, and Rewriting of Historiographical Texts in Medieval Iceland (TRANSLATIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Translated texts play an important role in the beginning of literacy in the vernaculars in the European Middle Ages. The process towards literacy is initiated by the arrival and then propagation of Christianity. Translation, however, did not only serve as a means to promote the new religion, it kept being an important tool for the import of cultural goods. The project will concentrate on historiographical texts translated from Latin into Old Norse. While it does not seem far fetched to assume that those translations might have had a function as literary models, one might also ask about the socio-cultural motivations and functions of those texts: Were the Icelanders only interested in importing the common matters which were in fashion everywhere in Europe? Or did they also import new concepts that came with the texts? And if so, how were they translated and transformed for the audience? Is it possible that some people even used certain texts to promote their political agenda? Who were those people? Where and who were their contacts? While the final goal could be called a “sociology of translation” on the novel theoretical background of Translation Studies, the methods are philological under the paradigms of Material and New Philology. With a background in Medieval Latin and Classics (MA) as well as Scandinavian Studies (PhD) I am ideally qualified to conduct research on texts translated from Latin into Old Norse. The European dimension of the EF makes it the ideal format for this project, since it would make it possible to work at the best institution for research in the field of Old Norse—the Arnamagnæan Institute in Copenhagen. The training in manuscript studies, digital humanities, and lexicography that will be provided in this first-rank institution in the field of Old Norse and the innovative monograph that will be the major outcome of this project will advance my career significantly and enhance my international employability in academia.

Keywords: medieval studies,middle ages,old norse literature,old norse,iceland,latin literature,historiography,germanic philology,translation studies
Neuronal regulation of immunity (NEIMO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Israel
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-11-01
End date: 2023-06-30
Duration (months): 68.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The philosophical ‘mind-body problem’ examines the relationship between the mind, a mental process, and its impact on the body, a physical entity. It has multiple manifestations in modern medicine, for example, the emergence of disease following stress, or recovery in response to placebo treatment. Nevertheless, this fundamental aspect of physiology remains largely unexplored. Here we propose to approach this question by focusing on a specific aspect of brain-body interactions. Namely, to study how the brain's interoceptive site, the insular cortex, affects the immune system, the body’s main protective mechanism. We will explore the interactions between the insula and the immune system on two levels. First, we will focus on the insula and its projections within the brain; secondly, we will study the role of projections from the brain, specifically, the peripheral nervous system (PNS), which innervates all the immunological organs. We will use chemogenetics to activate/inhibit the activity of neurons in the insula, and optogenetics to locally control, using light, the activity of sympathetic and parasympathetic neurons innervating immunological sites. We will then characterize the effects of these neuronal manipulations on the immune system to decipher fundamental principles of the dialog between nerve and immune cells with the long term goal of harnessing the brain’s therapeutic potential. My multidisciplinary background places me in a unique position to investigate brain regulation of immunity, and our preliminary data support our central hypothesis that the brain and, specifically, the insula, regulate immune responses. Taken together, this study promises to alter our understanding of brain-body interactions, and to set the stage for novel approaches to analyze how the state of the mind impacts physiology.

Keywords: psychoneuroimmunology,neuroimmunology
Preclinical validation of a novel immunogenic composition to stimulate innate immunity (STIMUNITY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-02-01
End date: 2018-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Immunotherapy is a promising approach to treat cancer and infectious diseases, but innovative approaches are required. The cGAS-cGAMP-STING pathway can induce a potent immune response against viruses. It is also implicated in antitumoral immune responses that are effective. We have recently discovered that the small second messenger cGAMP can be packaged by viruses to stimulate immunity in target cells. We have developed methods to produce non-infectious virus-like particles containing cGAMP (cGAMP-VLPs) that strongly stimulate this innovative immune pathway. We will test the idea that cGAMP-VLPs are potent activators of anti-tumoral and anti-viral immunity. To reach this proof-of-concept, we propose pre-clinical development plan in translational mouse models.

Keywords: innate immunity,immunotherapy,vaccine,virus like particles
“Valorization of European onion waste by-products into dietary fibre-based formula with hypocholesterolemic, hypoglycemic, and antioxidant effects” (FIBRACEP)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2018-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Being onions the second most important horticultural crop in the world (86 million tonnes, FAO 2014), production of onion waste has risen over recent years in Europe. Well over 500,000 tonnes of onion waste are generated in the European Union each year, mainly in Spain, The Netherlands, and the United Kingdom, becoming an economic (as high as €40/ton just considering disposal costs) and environmental problem (rapid growth of phytopathogens e.g. Sclerotium cepivorum (white rot) makes this waste also unsuitable to be used as fodder). At the same time, a third of ischaemic heart disease is attributable to high cholesterol, according to the World Health Organisation, and in high-income countries, over 50% of adults have elevated total cholesterol. The Spanish SME Dietary Molecular Diagnostics, S.L. (BIOMEB), a spin-off of the University of Lérida, identified a commercial opportunity, offering sustainability on the use of onion-waste via their patented bioactive product FIBRACEP: a new dietary fibre-based formula obtained from onion agricultural by-products with scientifically validated reduction of cholesterol adsorption by 20% and proven increase of HDL-cholesterol levels by 50% (clinical trials already carried out), being a clear breakthrough (both in terms of health impact and costs) compared to best available commercial products. BIOMEB aims, thorough SMEInst-1 project, to produce a feasibility study and business plan, including the validation of customer demand, scaling-up of production of raw-fiber, introduction of FIBRACEP in meat and bread, and encapsulation for pharma-industry applications. We will also explore the need for a SMEInst-2 funding request. BIOMEB team counts with the confirmed collaboration on main players in the sector: CEBACAT, Indulleida, Laboratorios Rubió, ARGAL, Grupo Leche Pascual, Carinsa, and B&D Nutritional Ingredients. BIOMEB aims to reach a turnover of €177M in 2022 thanks to FIBRACEP.

Keywords: circular economy,waste,re use,valorisation,onion,nutraceutical
Tilt Rotor INlet Innovative Design And Testing (TRINIDAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Germany,Netherlands,Netherlands,Netherlands
Call: Experimental characterization and optimization of the RH and LH Engine intakes configuration of the next generation Tilt Rotor (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-02-01
End date: 2022-04-30
Duration (months): 39.0
Total project cost (EUR): 3346396.25
EU funding (EUR): 3346396.25
Participants: 6
Project status: CLOSED

The TRINIDAT project adresses the aerodynamic characterization of an already available intake geometry (as supplied by ITD) and optimization of the intake performance by using CFD based optimization tools leading to redesigned high performance intake shapes to be implemented on the Next Generation Civil Tilt Rotor (NGCTR) configuration. A purpose of the optimization is to improve the flow steadiness and uniformity at the Air Intake Plane of the engines such as to comply with the requirements put forward by the engine manufacturer. The initial characterization and optimization will rely on dedicated CFD studies, the final validation will be made with full size model tests in DNW-LLF 6x6 wind tunnel, allowing reliable testing at full scale Mach and Reynolds conditions. For efficient testing of basic and optimized left hand and right hand intake geometries in airplane, helicopter and intermediate Extreme Short Take-Off and Landing mode, a modular wind tunnel model equipped with a remotely controlled tilting forward nacelle part will be designed and manufactured. A remotely controlled highly instrumented rotatable rake will be installed in the model to enable detailed and efficient measurement of the flow at the engine air intake plane. Apart from the aerodynamic optimization of the intakes, the project will also identify icing and snow conditions to be considered for certification and will subsequently analyse the ice and snow effects on the nacelle inlets and ducts to provide early input for anti icing measures that might be needed for NGCTR. The partners of the consortium, gathering renowned Research Centres (NLR, DNW), 2 Industrials (Deharde, ALTRAN), 1 SME (ADSE) and 1 University (UT), will use their complementary expertise and facilities to provide an optimized inlet geometry for NGCTR, based on CFD and wind tunnel analysis, with high potential for certification in snow/icing conditions. The TRINIDAT project will last 39 months for a total budget of 3,346,397€.

Keywords: ngctr,aerodynamic characterization,optimization of the intake,windtunnel tests,icing and snow conditions,certification,variable inflow conditions
Pilot Integration of 3nm Semiconducter technology (PIN3S)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Germany,Germany,Germany,Germany,Germany,Israel,Germany,Romania,Belgium,France,France,France,France,Netherlands,Netherlands,Netherlands
Call: ECSEL-2018-1-IA (H2020-ECSEL-2018-1-IA-two-stage, 2018)
Start date: 2019-10-01
End date: 2023-04-30
Duration (months): 43.0
Total project cost (EUR): 119166151.5
EU funding (EUR): 26752414.79
Participants: 29
Project status: SIGNED

The overall objective of the PIn3S project is to realize Pilot Integration of 3nm Semiconductor technology. This covers Process Integration, creation of Lithography Equipment, EUV Mask Repair Equipment and Metrology tools capable to deal with 3D structures, defects analysis, overlay and feature size evaluation. Each of these objectives will be achieved by cooperation between key European equipment developers like; ASML, Zeiss, Thermo Fisher, Applied Materials, Nova, KTI involved with their suppliers, involvement of a strong knowledge network based on Universities of Germany, Heidelberg University Hospital, and the Netherland, TU Delft and the University of Twente, complemented with key Technology Institutes such as imec and Fraunhofer. The project addresses Section 15 “Electronics Components & Systems Process Technology, Equipment, Materials and Manufacturing”, Major Challenge 4 “Maintaining world leadership in Semiconductor Equipment, Materials and Manufacturing solutions” and Major Challenge 1 “Developing advanced logic and memory technology for nanoscale integration and application-driven performance” of the ECSEL JU Annual Work Plan 2018. As set out in the Multi Annual Strategic Plan 2018, PIn3S addresses the ambition for the European Equipment & Manufacturing industry for advanced semiconductor technologies to lead the world in miniaturization by supplying new equipment and materials approximately two years ahead of introduction of volume production of advanced semiconductor manufacturers. With the results of the Pin3S project the consortium builds on realizing IC manufacturers to migrate to the 3nm Technology node which enables a class of new products which have more functionality, more performance and are more power efficient. As such it will form the bases for innovations yet to come enabling solutions that address the societal challenges in communication, mobility, health care, security, energy and safety & security.

Keywords: semiconductor process,equipment,nano,technology,and materials