Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ecology from Farm to Fork Of microbial drug Resistance and Transmission (EFFORT)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: Netherlands,Netherlands,Germany,Spain,France,Italy,Netherlands,Belgium,Germany,Denmark,Poland,Bulgaria,France,Belgium,Switzerland,Netherlands,Denmark
Call:  (FP7-KBBE-2013-7-single-stage, 2013)
Start date: 2013-12-01
End date: 2018-11-30
Duration (months): 60.0
Total project cost (EUR): 11646878.2
EU funding (EUR): 8999809.0
Participants: 20
Project status: CLOSED

EFFORT studies the complex epidemiology and ecology of antimicrobial resistance and the interactions between bacterial communities, commensals and pathogens in animals, the food chain and the environment.This will be conducted by a combination of epidemiological and ecological studies using newly developed molecular and bio-informatics technologies. EFFORT will include an exposure assessment of humans from animal/environmental sources. The ecological studies on isolates will be verified by in vitro and in vivo studies. Moreover, real-life intervention studies will be conducted aiming at reducing the use of antimicrobials in veterinary practice. Focus will be on understanding the eco-epidemiology of antimicrobial resistance from animal origin and based on this, predicting and limiting the future evolution and exposure to humans of the most clinically important resistance by synthesising different sources of information in our prediction models. Through its results, the EFFORT research will provide scientific evidence and high quality data that will inform decision makers, the scientific community and other stakeholders about the consequences of AMR in the food chain, in relation to animal health and welfare, food safety and economic aspects. These results can be used to support political decisions and to prioritize risk management options along the food chain. The EFFORT consortium is made up of 20 partners from 10 European countries: Belgium, Bulgaria, Denmark, France, Germany, Italy, the Netherlands, Poland, Spain and Switzerland. The senior investigators leading this proposal bring together complementary strengths antimicrobial resistance, food safety, epidemiology of food borne pathogens and risk modelling, environmental epidemiology and microbial ecology, exposure assessment, veterinary microbiology, preventive molecular characterization of AMR, genetics and biology of DNA transfer mechanisms, whole genome sequencing for bacteria and economics of animal diseases

Keywords: antimicrobial resistance,metagenomics,exposure assessment,food safety,microbial ecology,whole genome sequencing,resistome,animal welfare,veterinary medicine,biology of dna transfer mechanisms
Integrated solutions for Tuberculosis control in animals combining vaccination and multi-species diagnostics (WILDTBVAC)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: Spain,Switzerland,United Kingdom,Spain,Italy,Spain
Call:  (FP7-KBBE-2013-7-single-stage, 2013)
Start date: 2013-12-01
End date: 2015-11-30
Duration (months): 24.0
Total project cost (EUR): 1560900.0
EU funding (EUR): 998204.0
Participants: 8
Project status: CLOSED

Recent studies have showed estimations of worldwide 50 million cattle infections with M. bovis, at a cost to the agricultural community of 2-3 billion € per year. In developing countries, M. bovis infection is still widespread, in both cattle and humans. Even in developed countries, successful eradication of disease from livestock is hampered by the presence of wildlife reservoirs of M. bovis. Under these circumstances, a single case of a reportable disease in livestock can result in serious economic consequences for the producer, public, and governments. Within this scenario, there’s room and clear business opportunities for integrated control products or solutions that aim at addressing what is considered a global problem, animal tuberculosis. Our overall objective is therefore to take the results of the TB-STEP project - “Strategies for the eradication of bovine tuberculosis”, funded under FP7-KBBE-2007 with project number 212414, where most of the WildTBVac partners were involved, and build a pre-commercial set of TB control solutions by means of testing the technical and economical viability of the aforementioned integrated approach. WildTBVac specific objectives are the following: • To standardize and optimize the production of a TB Vaccine (prototype resulting of the TB-STEP project) • To evaluate several vaccine-compatible diagnostic strategies (also resulting from the TB-STEP project) that will include multi-species DIVA tests (wild boar, domestic pigs, cattle) • To assess the field efficacy of integrated TB control strategies including oral vaccination for TB control in wild boar • To evaluate the field efficacy of integrated TB control strategies including oral vaccination for TB control in domestic and feral pigs • To define the exploitation and commercialization strategy including clear technology transfer approaches and development of a market oriented business.

Keywords: standardization,validation,vaccine prototypes,new methods of diagnosis,knowledge transfer,business model
Optimized esterase biocatalysts for cost-effective industrial production (OPTIBIOCAT)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: Italy,Sweden,Germany,France,Netherlands,Sweden,Portugal,Netherlands,Netherlands,Netherlands,Finland,Greece,Germany,Germany
Call:  (FP7-KBBE-2013-7-single-stage, 2013)
Start date: 2013-12-01
End date: 2017-11-30
Duration (months): 48.0
Total project cost (EUR): 9170824.47
EU funding (EUR): 6851846.0
Participants: 18
Project status: CLOSED

OPTIBIOCAT is a 48 months project aimed at developing biocatalysts based on feruloyl esterases (FAEs) and glucuronoyl esterases (GEs) for production of phenolic fatty- and sugar- esters with antioxidant activity for cosmetic industry, expanding the number/type of industrial biotransformations. Selected FAEs and GEs available within the consortium will be improved for their thermo- and solvent- resistance and substrate specificity by site-directed mutagenesis and directed evolution. Novel enzymes will be discovered by mining for new genes from available genomes. An inventory of novel FAEs and GEs will be developed including 50 fungal and 500 bacterial esterases, 25 site-directed and 20 directed evolved mutants. Enzymatic performances will be optimized to enhance the yield (up to the theoretical yield of 100%) and productivity (up to 0.5-1 g/l/h) of reactions giving the main targeted antioxidants: butyl ferulate, p-coumarate, caffeate, sinapate and 5-O-(trans-feruloyl)-arabinofuranose (using FAEs), glucuronate and benzyl glucuronate (using GEs). FAEs and GEs will be also tested for production of other compounds with improved biological activity and properties of hydrophilicity/hydrophobicity for cosmetic applications. Cost-effective methods will be developed for production of the new biocatalysts, in the g/L scale, and for their technical application to produce antioxidants for cosmetic industry, up to 20L. Enzyme immobilization will increase their recyclability up to ten cycles. The ability of the developed catalysts to work in conditions miming the industrial ones with reduced use of solvents and lower temperature than the chemical routes will be demonstrated. The techno-economic viability and environmental friendliness will be assessed considering a full industrial scale scenario. OPTIBIOCAT involves a highly skilled and multidisciplinary partnership of 16 partners from 8 EU countries, and it is a strongly industry driven project through the participation of 8 SMEs and 1 large company.

Keywords: feruloyl/glucuronoyl esterases,phenolic fatty- and sugar- esters synthesis,antioxidant,cosmetics
Synthetic Biology for the production of functional peptides (SYNPEPTIDE)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: Switzerland,Netherlands,Germany,Germany,Austria
Call:  (FP7-KBBE-2013-7-single-stage, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 7170757.6
EU funding (EUR): 5558781.0
Participants: 7
Project status: CLOSED

Peptides are among the most versatile natural products that nature provides to cater for a broad set of biotechnological applications ranging from antibiotics to personal hygiene. Their diversity comes from a broad variety of posttranslational modifications that is used to provide additional functionality beyond to what is possible with the classic proteinogenic set of 20 amino acids. In SYNPEPTIDE, we want to recruit such additional functionality for rational molecular design purposes in order to facilitate the design and the production of synthetic peptides. To this end, we intend to standardize the integration of chemical diversity in peptide design and production by the following activities: [i] translational integration of chemically suitable non-canonical amino acids for posttranslational in vivo and in vitro modification; [ii] systematic recruitment of selected highly relevant posttranslational modifications from natural peptide synthesis routes into the design process. These activities will ultimately allow to drastically expand our arsenal of functionalities in the design of novel molecules and our capacity to reliably produce them.

Keywords: functional peptides - posttranslational modifications - non-canonical amino acids - peptide production - dna synthesis - standard building blocks - molecular evolution
Biosensors, Reporters and Algal Autonomous Vessels for Ocean Operation (BRAAVOO)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: Switzerland,Spain,Italy,Germany,Israel,Netherlands,Ireland
Call:  (FP7-OCEAN-2013, 2013)
Start date: 2013-12-01
End date: 2016-11-30
Duration (months): 36.0
Total project cost (EUR): 4564917.0
EU funding (EUR): 3529127.0
Participants: 9
Project status: CLOSED

BRAAVOO aims to develop innovative solutions for real-time in-situ measurements of high impact and difficult to measure marine pollutants. The concept of BRAAVOO is based on a unique combination of three types of biosensors, which will enable both the detection of a number of specific marine priority pollutants as well as of general biological effects that can be used for early warning. First, innovative bimodal evanescent waveguide nanoimmuno-sensors will enable label-free antibody-based detection of organohalogens, antibiotics, or algal toxins. Secondly, bacterial bioreporters producing autofluorescent proteins in response to chemical exposure will enable direct detection of alkanes or PAHs from oil, heavy metals, or antibiotics, and can further assess the general toxicity of the water sample. Finally, the photosystem activity of marine algae is exploited to monitor changes induced by toxic compounds. BRAAVOO will construct and rigorously test the three biosensor systems for their analytical performance to the targeted pollutants. To enable low-cost real-time measurements, the three biosensors will be miniaturized, multiplexed and integrated into innovative modules, which allow simultaneous multianalyte detection. The modules will include all optical elements for biosensor signal generation and readout, the microelectronics for data storage, and specific microfluidics to embed the biosensors or cells, and expose them to aqueous samples from dedicated autosamplers. The modules can be used either as stand-alone instruments for specific marine applications or can operate autonomously and in real-time in an integrated form. Hereto, they will be embedded in a marine buoy and an unmanned surveying vessel. Vessels and stand-alone biosensor modules will be tested extensively and in comparative fashion on real marine samples and in mesocosms. If successful, the flexible and innovative BRAAVOO solutions will democratize and revolutionize marine environmental monitoring.

Keywords: bioreporters,biosensors,marine environment,microfluidics
SenseOCEAN: Marine sensors for the 21st Century (SENSEOCEAN)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Sustainable use and management of land and seas
Action type: Collaborative project
Countries involved: United Kingdom,Denmark,Germany,France,Germany,Austria,United Kingdom,United Kingdom,France,Ireland,Germany
Call:  (FP7-OCEAN-2013, 2013)
Start date: 2013-10-01
End date: 2017-09-30
Duration (months): 48.0
Total project cost (EUR): 8065330.2
EU funding (EUR): 5924945.0
Participants: 12
Project status: CLOSED

SenseOCEAN brings together the leading sensor developers from academia and industry across Europe to enable a quantum leap in worldwide in situ ocean biogeochemical sensor technology. It will produce fundamental innovations in analytical sciences fusing together new techniques for microfabrication, system integration, self calibration and cost-effective mass production. It will deliver a new product; an integrated multifunctional biogeochemical sensor package that is small and low-cost yet will be rugged and high performance. This product will have a major impact on the ability of EU SMEs and industry to compete in the growing market of environmental metrology and networked ecosystems. The product will measure with high precision and accuracy all of the following: the oceanic carbonate system, nutrients, the micronutrient iron, oxygen, nitrous oxide, trace metals (specifically the micronutrient iron) together with optically observed parameters including photosynthetically active radiation, particulate organic carbon, Chlorophyll a, primary production, coloured dissolved inorganic matter and transmission. As such it will quantify at scientifically relevant performance all of the major state variables in ocean biogeochemical processes. These will be observed with a new generation of sensors using lab on a chip, micro electrochemical, optode, and optical sensor technologies. Crucially the system will be small, integrated and suitable for mass production enabling it to be scaled and used on mass deployed platforms such as the profiling float array (Argo) and on many other platforms. To enable this we will develop modular interfaces. The product will be developed in line with state of the art data management practice, which we will continue to develop in collaboration with the international community. We will deliver a near real time and also a quality controlled archived data product with the outputs from our new sensor technology.

Keywords: sensors,technology,marine,in-situ,commercialization,climate change,biogeochemistry
Real time monitoring of SEA contaminants by an autonomous Lab-on-a-chip biosensor (SEA-ON-A-CHIP)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: Spain,France,Italy,United Kingdom,Portugal,Spain,Austria,Greece,Norway,Spain,Romania,Sweden
Call:  (FP7-OCEAN-2013, 2013)
Start date: 2013-12-01
End date: 2017-05-31
Duration (months): 42.0
Total project cost (EUR): 7603006.08
EU funding (EUR): 5751459.0
Participants: 18
Project status: CLOSED

Early warning systems that can provide extreme sensitivity with exquisite selectivity are required to assess chemical contamination of estuarine and coastal areas. SEA-on-a-CHIP aims to develop a miniaturized, autonomous, remote and flexible immuno-sensor platform based on a fully integrated array of micro/nano-electrodes and a microfluidic system in a lab-on-a-chip configuration combined with electrochemical detection for real time analysis of marine waters in multi-stressor conditions. This system will be developed for a concrete application in aquaculture facilities, including the rapid assessment of 8 selected contaminants from 5 groups of compounds that affect aquaculture production (compounds which are toxic, bioaccumulative, endocrine disruptors) and also those produced by this industry that affect environment and human health (antibiotics and pesticides), but it is easy adaptable to other target compounds or other situations like coastal waters contamination analysis. Each device will be able to perform 8 simultaneous measures in duplicates and it will be build in order to work with one-month autonomy and measuring in real time at least once per hour. As many devices as needed could be connected simultaneously to the same platform resulting in a very flexible and inexpensive system. Sensitivity for Sea-Water analysis is guaranteed thanks to the use of gold microelectrodes arrays with metalocarborane doped functional polypyrrol. Thank to the use of MEMS and microlectrodes in flexible polymeric substrates the costs of production will be reduced. The units will be tested throughout the lifetime of the project and calibrated to state-of-the-art of chemical analytics: first in laboratory studies, second under artificial ecosystems and finally during 3 field experiments in the installation of 2 aquaculture SME facilities. The last test phase will be performed in a way that will include dissemination of the findings with a clear view of commercializing the devices.

Keywords: biosensor,immunosensor,real time analysis,miniaturized,autonomous,aquaculture,marine biotoxines,pesticides,antibiotics,remote
Re-thinking Judaism’s Encounter with the Roman Empire: Rome’s Political and Religious Challenge to Israel and its Impact on Judaism (2nd Century BCE – 7th Century CE) (JUDAISM AND ROME)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Consolidator grants
Action type: Support for frontier research (ERC)
Panel: The Study of the Human Past
Countries involved: France
Call:  (ERC-2013-CoG, 2013)
Start date: 2014-09-01
End date: 2019-08-31
Duration (months): 60.0
Total project cost (EUR): 1433123.0
EU funding (EUR): 1433123.0
Participants: 1
Project status: CLOSED

Scholars have studied the history of the relationship between Rome and the Jewish people in Antiquity from many angles; however, they have focused mainly on the political and military confrontation between the two. Recently, scholarship has turned to a new research agenda less focused on conflict: the examination of the Romanness of the Jews who lived in the Roman empire, and, in particular, that of the Palestinian Rabbis. While this new trend is both welcome and necessary in order to balance previous approaches, it still leaves an essential question unanswered, perhaps the great impensé of the encounter between Jews and Romans. Beyond Roman concrete political decisions concerning Jews, and the Jews’ adoption of Roman cultural features such as baths, how did Roman imperialism affect the ways Judaism – both rabbinic and non-rabbinic – defined itself? This project shall answer this question by analyzing an overlooked dimension of the problem. It will examine how Roman imperialism challenged Judaism both religiously and politically because of the rivalry – from the Jewish perspective – between Jewish and Roman universalisms and “messianic” ideals. This analysis shall make it possible to assess how the Jewish encounter with Rome contributed to shaping Judaism itself, in particular regarding sensitive issues such as the integration of non-Jews in Jewish society, the Jews’ conception of Jewish Law as a national and/or universal law, and Israel’s role in the establishment of a just universal political order. Moreover, in order to better comprehend the specificity of the Jewish responses to Rome, this study shall compare them to those of the Greeks and other peoples dominated by Rome, as well as to those of the Christians until the beginning of the fourth century CE. Finally, it shall try to assess the impact of the Christianization of the empire on the changes within Judaism that began with its encounter with “pagan” Rome.

Keywords: judaism,roman empire,rabbinic literature,universalism,law,peace,election,messianism,rivalry,self-definition.
Molecular Simulation: modeling, algorithms and mathematical analysis (MSMATH)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Consolidator grants
Action type: Support for frontier research (ERC)
Panel: Mathematics
Countries involved: France
Call:  (ERC-2013-CoG, 2013)
Start date: 2014-06-01
End date: 2019-05-31
Duration (months): 60.0
Total project cost (EUR): 1773600.0
EU funding (EUR): 1773600.0
Participants: 1
Project status: CLOSED

Many models for materials rely on a microscopic description. In a classical regime and for a fixed temperature, atoms are described by particles that interact through a force field and evolve according to Newton’s equations of motion, with additional stochastic terms to model thermostating. This simulation technique is called molecular dynamics. Applications are ubiquitous, ranging from biology to materials science. The direct numerical simulation of these models is extremely computationally expensive, since the typical timescale at the microscopic level is orders of magnitude smaller than the macroscopic timescales of interest. Many algorithms used by practitioners have not yet been investigated by applied mathematicians. The aim of this proposal is to further develop the mathematical analysis of these methods and to build new and more efficient algorithms, validated by precise error estimates. The underlying theoretical questions are related to the mathematical definition and quantification of metastability for stochastic processes. Metastability refers to the fact that the stochastic process remains trapped in some regions of the configuration space for very long times. Using naive simulations, transitions between these states are very rarely observed, whereas these transition events are actually those which matter at the macroscopic level. Metastability is one of the major bottlenecks in making molecular simulations predictive for real life test cases. The main challenges motivating this proposal are: the design of efficient techniques to sample high-dimensional multimodal measures, the development and analysis of algorithms to sample metastable dynamics and the construction of coarse-graining techniques for high-dimensional problems. This project relies on strong collaborations with practitioners (biologists and physicists) in order to propose common benchmarks, to identify the methodological bottlenecks and to apply new algorithms to real life test cases.

Keywords: molecular dynamics,monte carlo methods,metastability