Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Chromosomes on shuffle: disentangling the relative contributions of natural selection, sexual selection, and drift on the evolution of a chromosomal inversion. (ADAPTIVE INVERSIONS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

Comprehending adaptation is key to understanding our changing world. Despite this, we still know little about the genetic basis of adaptation. The picture becomes even more complex when we move beyond base pairs to large structural variation. Inversions may contain hundreds or thousands of loci but segregate largely as one unit, as they prevent recombination. Nonetheless, these giant genomic units seemingly facilitate rapid adaptation and speciation in a wide variety of taxa. The key objective of this project is to determine how inversions contribute to adaptation and how they evolve by systematically examining and disentangling the forces that govern the evolution of an inversion in a model species, the seaweed fly Coelopa frigida. I will combine interdisciplinary techniques to address crucial and novel aspects of the relationship between inversions and adaptation. I will be based at the Linnaeus Centre for Marine Evolutionary Biology (CeMEB), an interdisciplinary centre of research excellence at the University of Gothenburg (UGOT) in Sweden. Via training-through-research including a secondment to the Instituto Gulbenkian de Ciência in Portugal I will learn new techniques from multiple disciplines, including advanced scripting for analysis of next generation sequencing data, theoretical modelling, and reduced representation library preparation and analysis.

Keywords: adaptation,chromosomal inversion,cline
Novel braced frame for earthquake resilience (CBF-EQRES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-11-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The project will develop a seismic-resistant steel frame for high seismic resilience. The frame consists of a moment-resisting frame equipped with concentric braces. Replaceable energy-dissipative hourglass shape pins made of duplex stainless steel that results in high post-yield stiffness are in series connected to the braces. Moreover, replaceable fuses are introduced at the locations of the beams of the moment resisting frame where plastic hinges are expected to develop. The project uses an integrated experimental-numerical research methodology to evaluate the seismic performance of the proposed configuration. Emphasis is placed in developing a reliable seismic design methodology for the practical application of the proposed system.

Keywords: concentrically braced frame,mitigation of residual drifts,seismic resilience,high postyield stiffness,large scale testing,numerical models
High Risk Leadership in Latin America: Women's Pursuit of Gender Justice in Violent Contexts (High Risk Leadership)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom,Mexico
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-01
End date: 2024-10-29
Duration (months): 36.0
Total project cost (EUR): 234254.4
EU funding (EUR): 234254.4
Participants: 2
Project status: SIGNED

The proposed project is about women’s resistance to violence(s) in high risk settings in Latin America. In contexts of high violence, we might expect women – often portrayed as weaker or more vulnerable members of society – to shy away from activities that augment their exposure to risk. Dr Zulver’s previous research shows, however, that against all odds, women do engage in high-risk collective action. These women transgress traditional gender barriers and thus expose themselves to the additional risks of high violence. Not only are such women resisting violence, Zulver’s work shows that their activism focuses on the pursuit of gender justice. The project has two specific objectives: (1) to further document and explain women’s high risk mobilisation in the region (particularly in Mexico) and (2) to comparatively study women’s leadership in high risk social movements in the region. The project will serve the triple purpose of contributing to social movements literature on leadership, expanding understandings of High Risk Feminism, and advancing scholarship on women’s empowerment more broadly. In this setting, complex, robust information about leaders and women’s organisations who mobilise in spite of and because of the quotidian violence to which they are exposed is crucial. The project’s outputs include three peer-reviewed articles, a book manuscript (about women’s high risk leadership), op-eds in newspapers, a workshop for leaders of women’s organisations, seminar and conference presentations at international conferences, gender sensitivity training sessions for PhD students and early career researchers, and a database on women leaders in the region. The key goal of the Fellowship is to establish Dr Zulver at the forefront of her field as an expert on women’s mobilisation in violent contexts. It will directly benefit her career prospects by equipping her with specialised knowledge and personalised training.

Keywords: gender justice,south america,mexico,leadership
MAchine for Time Reversal and Immersive wave eXperimentation (MATRIX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-12-01
End date: 2022-11-30
Duration (months): 72.0
Total project cost (EUR): 3498330.0
EU funding (EUR): 3498330.0
Participants: 1
Project status: CLOSED

There is a need for a radically new laboratory experimental approach for studying the interaction of seismic waves with the complex media of the Earth’s subsurface. We present here a fundamental new approach to seismic wave experimentation that involves fully immersing a physical seismic experiment within a virtual numerical environment. This enormously challenging endeavour, which is relevant to many outstanding issues in seismology, has not been previously attempted. By continuously varying the output of numerous transponders closely spaced around the physical domain using a control algorithm that takes advantage of measurements made by a scanning Laser-Doppler Vibrometer and a novel theory of exact boundary conditions, waves travelling between the physical and numerical domains will seamlessly propagate back and forth between the two domains without being affected by reflections at the boundaries between the two domains. This will allow us to investigate diverse types of Earth materials using frequencies that are much closer to those of seismic waves propagating through the Earth than previously possible. The novel laboratory enables experimentation under highly controlled conditions. A broad range of long-standing problems in wave propagation and imaging that have eluded Earth scientists and physicists for decades will be addressed. Fine scale heterogeneity, porosity and fluid saturation in real Earth media result in complex frequency-dependent amplitude and phase responses that we can characterize in the laboratory. Synthetically produced complex models can be used in wavefield-focussing experiments and to achieve complete elastic time-reversal for the first time ever. We will study coda waves that can be indicative of slight changes in stress fields before catastrophic fracturing and that might provide pre-cursory signs of earthquakes. Finally, the laboratory is highly relevant to applications such as non-destructive testing, medical imaging and lithotripsy.

Keywords: wave propagation,physical modelling,immersive experimentation,scattering of elastic waves
Alzheimer's Disease (AD) Detect & Prevent - Presymptomatic AD detection and prevention (AD Detect-Prevent)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Belgium,Denmark,United Kingdom,Luxembourg,Denmark
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2018)
Start date: 2018-11-01
End date: 2022-04-30
Duration (months): 42.0
Total project cost (EUR): 3880990.31
EU funding (EUR): 2936546.06
Participants: 6
Project status: CLOSED

Alzheimer’s disease (AD) is central to the rapidly growing and crushing ageing challenge that threatens to economically undermine today’s health care system. AD prevalence will grow to over 100m cases in 2050. AD is incurable, but can be prevented. Detecting pre-symptomatic signs of AD in at-risk groups and intervening early may be the only viable solution. Our target is to bring to market a novel ICT tool, named ‘AD Shield’, that screens for and detects pre-symptomatic stage cognitive decline related to AD, and creates a personalized program for each individual user to strengthen weakened cognitive abilities, thus building cognitive reserve and reducing AD risk. Brain+ will collaborate with world leading neuroscientists to validate this ICT tool. Completion of the tasks described in the workplan will secure the remaining development adaptation combination and validation of the existing technological breakthroughs of the Brain+ method and ICT platform, including the Oxford University’s new highly sensitive cognitive assessment method. The end product will be a scientifically validated, effective, economic, engaging and easily accessible method for pre-symptomatic detection of AD and preventative training. 'AD Shield' can be value created and costs saved of up to €60.000 per patient for the healthcare payers, and at EU level saving can amount to €7bn-108bn direct costs per year and €155bn informal care costs per year. Success stemmed from this phase 2 project will also empower AD at-risk groups and allow them to stay active in the labour market for longer. The combination of costs saved will ultimately boost EU competitiveness.

Keywords: gamification,applied games,digital brain games,neurodegenerative dissease,ageing,alzheimer s disease,dementia,cognitive decline,pre symptomatic,sub clinical,detection,preventative
Comparative transcriptomics of phylogenetically selected pathogenic treponemes cultivated in vitro under different conditions: First insight to the expression changes linked with genomic variants (ComTransTrep)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2023-06-04
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Syphilis, caused by the bacterium Treponema pallidum subsp. pallidum (TPA) is considered a re-emerging disease with over 5.6 million cases worldwide. Despite causing severe life-threatening infections, very little is known about the basic biology and pathogenesis of TPA, largely as the result of the inability to routinely propagate it in vitro. The recently described in vitro culture model (containing rabbit epithelial cells) has opened new avenues for the study of the basic biology of this pathogen. The ultimate goal of my research proposal is to take advantage of the in vitro model and link its use to high throughput genomic approaches to provide unique insights into the gene expression profiles of this pathogen. This has been transformative for other bacteria, enhancing our knowledge of genetic regulation: essential genes vs differentially expressed genes and intra- and inter-strain differences in response to different growth conditions. This has not been possible until now for TPA. Here, I will perform dual RNA-seq of multiple strains grown in vitro under different conditions. This research proposal has three aims. First, to describe global gene expression patterns of phylogenetically selected TPA strains. Second, to describe genome-wide interaction-linked transcriptional alterations of the infected host cells. And lastly, to correlate the whole transcriptome data with genomic and allelic diversity we see in circulating clinical TPA populations. This project will generate novel fundamental data which can lead to identification of functional pathways and prediction of the function for hypothetical genes, give light to the patterns of selection we see in genomic data and a better understanding of the key growth dependencies that could inform future axenic cultivation of TPA and combined a better understanding of basic biology introduce a more mechanistic understanding to surveillance and genomic epidemiology.

Keywords: pathogenic treponemes,in vitro cultivation,rna seq
Bridging biophysics and cell biology: The role of G protein-coupled receptor conformations in signalling (signalling dynamics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2022-12-31
Duration (months): 36.0
Total project cost (EUR): 271732.8
EU funding (EUR): 271732.8
Participants: 2
Project status: CLOSED

G protein coupled receptors (GPCRs) are a class of membrane receptors that transmits extracellular signals into the cell. They can be activated by a diverse set of ligands including small molecules, hormones, neurotransmitters or photons and are targeted by a third of currently marketed drugs. Endogenous ligands and drugs may exhibit different efficacy profiles, ranging from full activation to complete inactivation of a signalling pathway. The key to the selective interaction with signalling partners in response to ligand binding lies in the conformational flexibility of the membrane receptors. Previous research has extensively studied the three-dimensional structures of GPCRs and their signalling. However, the link between active conformations and signalling is still missing. In the proposed project, first I will use exhaustive single-point mutagenesis coupled to functional assays to determine how the sequence and secondary structure of GPCRs contribute to signaling. Second, biophysical techniques studying protein conformations will help us to understand the connection between conformations and signalling outcome. These techniques give insights into the conformational fingerprints of the receptor. The link to signalling will be achieved by biasing the receptor towards a selected signalling partner either though addition of the selected signalling partner or the insertion of specific mutations tested in the first part of the project. Finally, I will use computational techniques to compare the activation of signalling partners in different GPCRs. With my research I hope to improve our understanding of the molecular basis of membrane protein function and contribute to the development of strategies for the design of more specific drugs with fewer side effects.
Combining optoacoustic imaging phenotypes and multi-omics to advance diabetes healthcare (OPTOMICS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Estonia,Germany,Germany,Finland,Sweden,United Kingdom
Call: FET Proactive: emerging paradigms and communities (H2020-FETPROACT-2020-2, 2020)
Start date: 2021-01-01
End date: 2026-12-31
Duration (months): 72.0
Total project cost (EUR): 4414127.5
EU funding (EUR): 4414126.55
Participants: 6
Project status: SIGNED

Diabetes has emerged as a global pandemic affecting more than 420 million people worldwide, a number expected to further rise in the next decades. The disease has very heterogeneous outcomes and accurate patient staging or prediction of subsets of individuals likely to develop disease and/or progress to disease complications are currently unmet clinical challenges in need of urgent attention. OPTOMICS aims to research methodology that can deliver a paradigm shift in type 2 diabetes healthcare, by integrating 1) molecular phenotyping, 2) a new generation of phenotypic measurements in humans, representative of diabetes onset and progression, allowed by novel portable and non-invasive optoacoustic technology and 3) cutting-edge computational approaches leveraging progress in Artificial Intelligence. This research will develop and validate a digital twin model that catalyses a step change in shortening the path to translation, enabling applications in the entire spectrum from target identification & prevention/prognosis to patient stratification for type 2 diabetes and its complications. In addition to the research and technology goals, OPTOMICS places special attention to the ethical needs and implications of the work performed and further aims at exemplary project management, human measurements, dissemination and communication activities and updating an adept exploitation plan for the digital twin developed.

Keywords: diabetes,proteomics,metabolomics,genotyping
Supporting FET projects to reach out investors (FET2RIN)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Italy,Belgium
Call: FET Take-Up Coordination and Support Activities 2015 (H2020-FETOPEN-2015-CSA, 2015)
Start date: 2015-12-01
End date: 2019-04-30
Duration (months): 41.0
Total project cost (EUR): 472468.75
EU funding (EUR): 472468.75
Participants: 3
Project status: CLOSED

FET2RIN aims at facilitating collaborations to set the ground for the take up of FET projects by overcoming obstacles related to market outreach and accessing business leaders including entrepreneurs, early stage investors and crowdfunding communities. FET2RIN will deliver adhoc capacity building and market acceptancy actions to FET project partners to allow them to focus on novel exploitation rutes and unconventional business models to better meet the need of future societal and commercial impact. Proposed actions will stimulate researchers, entrepreneurs, business leaders working together to mutually understand opportunities disclosed by FET and cross-fertilize. Mentors and unconventional stakeholders business leaders, crowdfunding platforms will be engaged to validate market assumptions and speed up take up. Parnters will provide methodological support and capacity building actions based on the new trend of the customer validation process. To maximize impact, leverage on social recognition, seed opportunities for improving innovation potential of FET FET2RIN will reach out with ad hoc actions its target groups (FET Projects, entrepreneurs, business leaders, bakers) and offer opportunities for the mutual engagement of these communities when looking for market validation and acceptancy for FET results. Business leaders entrepreneurs will act as mentors for FET projects during capacity building customers and end users will be actively contacted leaving the labs. Such interaction among different communities and typology of stakeholders (for profit and not for profit, conventional and unconventional, etc.) will promotes cross-fertilization, mutual understanding and open up opportunities for further cooperation and take up.

Keywords: crowdfunding,investors,customer discovery,awareness raising
Developing advanced Engine Multi-disciplinary Optimization Simulations (DEMOS) (DEMOS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Greece,United Kingdom
Call: Advanced predictive models development and simulation capabilities for Engine design space exploration and performance optimization (H2020-CS2-CFP01-2014-01, 2014)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 410450.0
EU funding (EUR): 410450.0
Participants: 5
Project status: CLOSED

The “Innovative Aircraft Architecture” technology stream of the Clean Sky 2 Airframe ITD focuses on advanced power-plant solutions (such as CROR and UHBR) that are able to deliver a significant gain in aircraft performance. Project DEMOS will develop advanced predictive modelling and simulation capabilities for engine design space exploration and performance optimization of such novel propulsion systems. The overall and detailed objectives of Project DEMOS may be summed up as follows: • Assess, adapt and further develop a set of reliable and robust models to simulate/optimise performance of UHBR propulsion system architectures • Identify, build and integrate simulation models of specific (novel) components which may be considered as enablers of the technology • Demonstrate and assess the effect and influence of these components on the propulsion system performance in terms of overall performance, increase in mass, effect on lifing characteristics of the propulsion system and on the operating/ maintenance cost • Develop a modular approach to enable integration and further development of main modules/models for preliminary design process • Facilitate complex integration requirements • Improve process efficiency through the development of advanced solvers and adequate numerical methods to address complex system simulations • Development of advanced simulation techniques to improve the monitoring of communication between integrated models, robustness and convergence • Enable complex propulsion system performance optimisation with constraint handling capability • Develop a suite of advanced solvers to enable extended transient capabilities and simulation of complex systems transients and control The project will build on the established multi-disciplinary concept design tools and further develop and adapt them in terms of applicability to advanced technologies and multi-objective concept analysis and selection.

Keywords: simulation gas turbine engine optimisation design solvers