Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
InDx - an innovative implant that restores natural motion to patients with thumb base joint arthritis (InDx)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Germany,Ireland,Ireland,United Kingdom
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2018)
Start date: 2019-07-01
End date: 2021-12-31
Duration (months): 30.0
Total project cost (EUR): 3633125.0
EU funding (EUR): 2543187.5
Participants: 4
Project status: CLOSED

The thumb base joint is fundamental for human dexterity and functional activity but is prone to debilitating arthritis. Approximately 5% of the world population suffers from this condition with over 25 million Europeans affected. Simple tasks become impossible such as getting dressed, opening a jar, using a key to open a door. This is certainly a relevant socioeconomic and humanitarian concern, which causes a substantial cost burden on healthcare systems, yet the effective treatment for end-stage thumb base arthritis lags far behind other joints, given challenges of the small, complex anatomy. The InDx project aims to enable the commercialization of the InDx implant, the world’s first implant designed to accommodate the complex biomechanics of the thumb base joint and restore the natural movement of the thumb. The consortium is led by Loci Orthopaedics, a technology-driven SME spin-out company from the National University of Ireland, Galway. The partners include EndoLab in Germany, that has developed a novel dynamic test station for implants, NAMSA in the UK, a leading medical research organization with extensive experience in running international clinical investigations, and Medvie, an Irish based SME with extensive project management, dissemination and commercialization expertise. Together, the consortium have brought the implant to TRL 6 level. As part of the InDx project, the consortium will undertake the final stages of product development and will validate clinical results in a clinical study that will prepare the CE marking and market access. Market launch is planned within 24 months from the project start date, following FDA 510K approval in the USA and CE marking in Europe. The consortium estimates cumulative revenues of €51M within 5 years from the start of commercialisation and an employment growth of 25 FTEs for the consortium partners. The InDx has the potential to be a disruptive innovation in the surgical management of thumb base joint arthritis.
Capacity-building in Arctic standardisation development (CAPARDUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Coordination and support actions
Countries involved: Germany,Norway,Russian Federation,Norway,France,Denmark,Greenland,Japan
Call: The changing cryosphere: uncertainties, risks and opportunities (H2020-LC-CLA-2019-1, 2019)
Start date: 2019-12-01
End date: 2023-05-31
Duration (months): 42.0
Total project cost (EUR): 2021009.25
EU funding (EUR): 2003009.25
Participants: 9
Project status: SIGNED

CAPARDUS is a CSA project under H2020 with focus on capacity-building to develop guidelines, practices and standards in selected Arctic topics. These include data collection and management related to natural resource management, tourism, safety, community planning and decision making. The project develops a framework for development of standards as a collaborative effort between scientists, local communities and other stakeholder groups involved in the case studies in Greenland and Svalbard, with contribution from studies in Alaska and Yakutia in Russia. The project organizes a number of workshops, dialogue meetings and research schools as part of case studies in local communities, showing how the social-environmental systems are changing Arctic communities and what are the drivers for these changes. The climate change and its consequences in the Arctic leads to new requirements for planning and decision-making based on scientific and economic data, assessments and predictions. A prerequisite for good planning is access to data and information of relevance to the operators in the Arctic. CAPARDUS promotes and supports the Community-Based Monitoring and Citizen science as a contribution to data collection and knowledge building. The project will provide requirements and recommendations for an Arctic Practice System to the benefit of both local communities and other actors in the Arctic. At the end CAPARDUS will summarize the emergence of guidelines, practices and standards, supporting a sustainable development in the Arctic.

Keywords: guidelines,standards,best practices,local communities,digital resources
Targeting epigenetic REPROGRamming of innate immune cells in Atherosclerosis Management and other chronic inflammatory diseases (REPROGRAM)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Switzerland,Romania,Poland,France,United States,Netherlands,Netherlands,Netherlands,Denmark
Call: Understanding common mechanisms of diseases and their relevance in co-morbidities (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 6000000.0
EU funding (EUR): 5250000.0
Participants: 11
Project status: CLOSED

Up to 70% of cardiovascular events are not prevented by current therapeutic regimens. In search for additional, innovative strategies, immune cells have been recognized as key players contributing to atherosclerotic plaque progression and destabilization. Particularly the role of innate immune cells is of major interest, following the recent paradigm shift that innate immunity, considered to be incapable of learning ability, does exhibit a memory feature transduced via epigenetic modulation. Compelling evidence shows that atherosclerotic factors promote immune cell migration by pre-activation of innate immune cells. In this project called REPROGRAM, we aim to prove that innate immune cell activation via epigenetic reprogramming perpetuates the upheld systemic inflammatory state in cardiovascular disease which is common in other chronic inflammatory diseases. This opens a new therapeutic area in which epigenetic modulation of innate immune cells effectively decreases systemic inflammation impacting on chronic inflammation as well as the development of co-morbidities. The integrated use of in vitro, ex vivo and in vivo studies, including cells, mice and patients, allows translation from in vitro mechanisms to diseases (molecule-to-man) and extrapolation to cohorts (man-to-mass), enabling us to demonstrate relevance and therapeutic potential of targeting trained immunity in cardiovascular and chronic inflammatory diseases. Enforced by the promising data in oncology, the future prospects for epigenetic interventions in cardiovascular and chronic inflammatory diseases are eminent, attested by the large residual cardiovascular disease burden and the huge societal impact of other chronic inflammatory diseases. The REPROGRAM consortium consisting of key opinion leaders in the field of cardiovascular (systems) biology, immunology, epigenetic therapies and rheumatoid arthritis, with a large intersectoral network, guarantees rapid translation of early mechanistic discoveries

Keywords: atherosclerosis,chronic inflammatory diseases,trained immunity,epigenetic modulation,co morbidities
The Microfoundations of Authoritarian Responsiveness: E-Participation, Social Unrest and Public Policy in China (RESPONSIVENESS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Austria
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2021-10-31
Duration (months): 66.0
Total project cost (EUR): 1292440.0
EU funding (EUR): 1292440.0
Participants: 1
Project status: CLOSED

China’s success story of the past three decades is seen as an anomaly. Market-based reforms have generated an economic system that can hardly be described as socialist anymore, but the Communist Party of China remains in power. Although social unrest is on the rise, the CCP enjoys the consent of the overwhelming majority of its people. Most agree that China’s economic performance is the key to solving this apparent puzzle, but how can extraordinary high rates of public support be maintained in a country where income inequality is so extreme? We believe that the answer to this question lies in the responsiveness of China’s authoritarian one-party regime to popular demands and grievances, a capability that has so far been attributed only to democratic regimes. We further believe that the rapid improvement of e-participation, the opportunity to evaluate public services on the Internet, has greatly facilitated regime responsiveness - China’s score in the United Nations e-participation index is higher than the European average. We suggest, however, that as the government increasingly calibrates public policy towards satisfying the demand of China’s netizens, the "technologically illiterate" are forced to express their demands in public protests and other forms of social unrest. The proposed project sheds light on the intended and unintended consequences of enhanced e-participation in China by exploring which social interests China’s rulers incorporate into public policy making, and how these decisions influence the propensity of particular social groups to voice their demands by either participating online or taking to the streets. By exploring the “complex system” in which online complaints, social unrest and public policy interact, the project provides insights into the micro-foundations of regime responsiveness in China. It thereby increases our knowledge of how the CCP seeks to defer the antagonism that prompted the revolutions in Egypt, Tunisia and Syria.

Keywords: responsiveness,authoritarianism
Embedded Markets and the Economy (EMBED)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: India,United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-06-01
End date: 2023-05-31
Duration (months): 60.0
Total project cost (EUR): 1449106.0
EU funding (EUR): 1211863.63
Participants: 2
Project status: SIGNED

EMBED takes a microeconomic approach to investigating the macroeconomic implications of market transactions being embedded in social relationships. Sociologists and economists have documented the importance of relationships for mediating trade in a wide range of market settings. EMBED seeks to investigate the implications of this for the economy as a whole. Ethnographic work suggests that relationships foster common understandings which limit opportunistic behaviour. Subproject 1 will develop a first relational contacting theory of networked markets to capture this, and test these predictions using data from the Bundesbank. Formally modelling dynamic business-relationships, these relationships can be viewed as social capital. We will investigate whether this social capital is destroyed by economic shocks, and if so how long it takes to rebuild. Subproject 2 will run a field experiment. We will intervene in a networked market to create new relationships in a variety of ways. The varying success of these approaches will help us better understand the role of relationships in markets. Moreover, as a result we’ll get exogenous variation in the market structure that will help identity the affects relationships have on market outcomes. Subproject 3 will explore frictions in the clearing of networked markets. As the data requirements to empirically test between different theories are extremely demanding, laboratory experiments will be run. Breaking convention, these experiments will be protocol-free, although interactions will be closely monitored. This will create a more level playing field for testing different theories while also creating scope for the market to develop efficiency enhancing norms. Subproject 4 will examine firm level multi-sourcing and production technology decisions, and how these feed into the creation of supply chains. The fragility of these supply chains will be investigated and equilibrium supply chains compared across countries.

Keywords: networks,embeddedness,networked markets,field experiments,finance,relational contracts,random graphs
Super Productive Line Printing Inkjet (SUPPLEPRINT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 2244546.25
EU funding (EUR): 1571182.38
Participants: 1
Project status: CLOSED

TOPJET s.r.l. was established 26 years ago with the purpose of designing and manufacturing the best production labelling and printing systems for our customers packaging. Our cutting-edge products, has allowed us to compete with the leaders in the industry worldwide, with well-known brand companies. The SupplePrint Inkjet Printing System is a revolutionary, modular packaging printing machine studied to reduce substantially productions costs, given its real-time printing technology designed to be adaptable to production lines and dedicated projects. This machine increases flexibility and eliminates current systems limitations allowing to switch configurations quickly and easily from one package design, size and material to another, therefore allowing for smaller production batches, greater speed and high-resolution graphics at a lower price.

Keywords: inkjet printing,labelling printing,packaging,inkjet printing system ips
Coordination of International Research Cooperation on soil CArbon Sequestration in Agriculture (CIRCASA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Coordination and support actions
Countries involved: Austria,Germany,Australia,South Africa,Germany,Madagascar,Russian Federation,New Zealand,Belgium,China,Colombia,France,France,United States,Netherlands,Denmark,United Kingdom,United Kingdom,Brazil,Nigeria
Call: Supporting international cooperation activities on agriculture soil contribution to climate change mitigation and adaptation (H2020-SFS-2017-1, 2017)
Start date: 2017-11-01
End date: 2021-02-28
Duration (months): 40.0
Total project cost (EUR): 3837801.25
EU funding (EUR): 2451771.0
Participants: 23
Project status: CLOSED

Targeting ambitious changes in agricultural practices that would preserve restore and enhance soil carbon and soil health requires an increased coordination of international research cooperation. The specific challenge lies in the identification, implementation and verification of agricultural soil management practices which create a positive soil/ecosystem carbon budget at the farm and landscape levels, sequester carbon, improve soil structure and soil quality and provide climate change adaptation while contributing to sustainable development. In this context, the CSA CIRCASA has an overarching goal to develop synergies on research in this field at European Union and global level, targeting four realistic and highly complementary objectives: O1. Strengthen the international research community on agricultural soil carbon sequestration; O2. Provide an improved understanding of agricultural soil carbon sequestration and its potential for climate change mitigation and adaptation and for demands of increased food production; O3. Synthesizing stakeholder’s views and knowledge needs on agricultural soil carbon sequestration and climate change O4. Favor a more structured approach, by preparing an International Research Consortium (IRC) These four objectives will produce measurable outputs during the time frame of the project and create significant outcomes for the implementation of the UN Sustainable Development Goals (SDGs) and of the Paris agreement (COP21, 4 per 1000 voluntary initiative) of the UN Framework Convention on Climate Change (UNFCCC). CIRCASA will benefit from the participation of three major initiatives: the Global Research Alliance on agricultural greenhouse gases (GRA), the Joint Programming Initiative on Sustainable Agriculture, Food Security and Climate Change (FACCE JPI) and the 4 per 1000 - Soils for Food Security and Climate - initiative, and from the contribution of the CCCAFS and the WLE programs of the CGIAR.

Keywords: soil carbon sequestration,international research consortium,land management,strategic research agenda
Twin to Illuminate Metals in Biology and Biocatalysis through Biospectroscopy (TIMB3)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Italy,Portugal
Call: Twinning (H2020-WIDESPREAD-05-2017-Twinning, 2017)
Start date: 2018-09-01
End date: 2022-06-30
Duration (months): 46.0
Total project cost (EUR): 994367.5
EU funding (EUR): 994367.5
Participants: 3
Project status: CLOSED

TIMB3 offers the unique opportunity to capitalize on the existing infrastructure and human resources of ITQB-NOVA (Portugal) on biospectroscopy applied to the study of metals in biology to raise its scientific profile and achieve integration in the top league of research intensive institutions. The essential role of metals in biology is well recognized even by the general public (think of iron in blood). Notwithstanding, there is a growing appreciation of the potential of their study to radically transform our capacity to improve health and well-being and to develop novel biotechnological solutions to pressing environmental problems. This project emerges from successful test runs with the world class partners CIRMMP (Italy) and TUB (Germany), using networking instruments of narrower reach such as COST actions and bilateral partnerships. The scientific theme underlying the execution of TIMB3 is the enhancement of the capacity of ITQB-NOVA in performing world class research in biospectroscopy applied to metal homeostasis and trafficking and applied to bioinspired catalysis. The research profile of ITQB-NOVA staff will be raised by a combination of exchange missions with counterparts on the partner institutions, and structured training events on scientific and soft skills, including project writing and IP awareness. These activities will enable ITQB-NOVA to create a virtual platform for biospectroscopy to be used by non-specialists to learn the potential of this versatile group of methods to solve their specific research and development problems, broadening the social awareness to the capacities of biospectroscopy applied to the study of metals in biology. At the end of TIMB3, ITQB-NOVA will be able to enter international scientific consortia and compete for funding at the highest level establishing itself as a bona fide member of the top league of research intensive institutions.

Keywords: metals biology,vibrational spectroscopy,biocatalysis
Delineating epigenome regulators as functional survival dependencies in intrahepatic cholangiocarcinoma. (EPiCC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: SIGNED

Intrahepatic cholangiocarcinoma (iCC) is an aggressive malignancy of the biliary tract with escalating rates among both sexes in EU. Patients survive less than one year from diagnosis due to limited treatments and innate chemoresistance. Genomic analyses have identified recurrent mutations in epigenetic regulators in iCC. Malfunction of such genes has genome-wide consequences for epigenome-remodeling and transcriptome homeostasis, though this remains largely uncharacterized in iCC. Further, the extent to which iCC survival depends on these epigenetic alterations has not been determined. Clarification of these dependencies on epigenetic alterations, which unlike mutations are reversible, is crucial for the development of precision epigenome-targeted therapies for this aggressive disease. Using patient-derived cell lines (PDCLs), I propose to characterize iCC epigenetic survival dependencies to define the functional role(s) of key epigenetic regulators and ensuant epigenome remodeling, in turn identifying putative novel therapeutic targets. To achieve this, I have divided my EPiCC proposal in 2 specific aims: 1.Identify iCC-selective functional survival dependencies by state-of-the-art CRISPR/Cas9 screening. 2.Characterize the anti-neoplastic cellular and (epi)genomic consequences induced by the top epigenome regulator loss. Through integrating novel comprehensive approaches in iCC (CRISPR/Cas9 screening, R-loop mapping) with robust patient models (primary cells, omics from patient samples), I will provide novel insight into the epigenetic landscape of iCC and identify potential targets for future development of epigenetic-based precision medicine. This study will be supervised by Dr. Andersen, leading expert in the field of hepatobiliary cancers and translational genomics research. Therefore, EPiCC will provide me with new scientific expertise (both technical and transferable skills), a broader network and open new research avenues to follow up in my career.

Keywords: cholangiocarcinoma,translational epigenomics,epigenetic therapy,r loops