Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nanoscale dendrite formation and mitigation in high-energy density metal anodes (NANODENDRITE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

High-energy density batteries based on metal anodes (Li, Na, K) are urgently required to meet the demands of modern electric vehicles. However, their commercial success has been impeded by the uncontrolled dendritic growth, which causes serious capacity losses and safety issues. Understanding the mechanisms of dendrite formation, which still remain unclear, would be a critical breakthrough to achieve high-performance metal anode batteries. This proposal presents an innovative new approach to provide a holistic understanding of metal dendrite formation and mitigation beyond the state-of-the-art that will accelerate the rational design of ideal anode materials, through the implementation of quantitative electrochemical microscopy techniques, co-located structural microscopy and computational modelling. The scientific scope encompasses gaining definitive insights on dendrite formation and mitigation by: (i) revealing precise conditions and intricate nucleation and growth events governing dendrite formation during the electrodeposition of Li, Na, K and Mg at the nanoscale using a unique high-throughput electrochemistry platform; (ii) visualising nanoscale electrochemistry at nano-engineered electrode surfaces to unveil how nucleation sites work together to achieve dendrite mitigation; (iii) correlating nanoscale knowledge of dendrite formation and mitigation to the performance of a macroscale battery through the rational design of anode materials. The project brings together the unique expertise of the Fellow, Dr. Daniel Martín-Yerga, in electrochemistry and nanoscience with that of the Host group, world-leading on correlative electrochemical microscopy and modelling, to create an approach that will greatly advance the battery field. The Fellow will acquire exceptional scientific and transferable skills, with world-class support from the Host group and its collaborators, providing him with an outstanding opportunity to develop personally and professionally.

Keywords: electrodeposition,electrochemical imaging,scanning probe microscopy,metal nucleation and growth,batteries,metal anodes
Molecular and structural pharmacology of adiponectin receptor: towards innovative treatments of obesity-related diseases. (ADIPOR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2020-12-31
Duration (months): 66.0
Total project cost (EUR): 1989518.0
EU funding (EUR): 1989518.0
Participants: 1
Project status: CLOSED

The human kind is witnessing an escalation of obesity-related health problems such as cardiovascular diseases and type 2 diabetes. A recent groundbreaking study revealed adiponectin receptors (ADIPOR) as key targets for treating such obesity-related diseases. Indeed, the modulation of this integral membrane protein by small molecules agonists ameliorates diabetes and prolongs lifespan of genetically obese rodent model. Despite these exciting results and the importance of ADIPOR in human physiology, there is a complete lack of knowledge of ADIPOR mechanisms of action and pharmacology. This is mainly due to the challenges associated with the characterization of membrane protein structure and function. To fill this gap of knowledge and based on my extensive experience in membrane protein biology, I propose here to characterize the the proximal signaling pathways associated with ADIPOR activation as well as the molecular and structural mechanisms of ADIPOR activation. We will develop an innovative integrated strategy combining state-of-the-art molecular and structural pharmacology approaches including 1) molecular analyses of ADIPOR network of interaction using resonance energy transfer measurement in living cells and a proteomic analysis and 2) structural analyses of ADIPOR and signaling complexes using biophysics and X-ray crystallography. Our data will have a major impact on drug discovery for treating obesity-related diseases as it will enable the application of structure-based drug design and in silico screening for the molecular control of ADIPOR activity. The proposed high-risk endeavor of obtaining structural data on these atypical membrane signaling complexes is a new direction both for my career and for the field of adiponectin biology; the exceptionally high gain from these studies fully justifies the risks; the feasibility of this project is supported by my recent success in membrane protein pharmacology, biochemistry, biophysics and crystallography.
Immunity, DEvelopment and Microbiota: Understanding the Continuous Construction of Biological Identity (IDEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: France,France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2020-12-31
Duration (months): 64.0
Total project cost (EUR): 1454249.99
EU funding (EUR): 1454249.99
Participants: 2
Project status: CLOSED

The problem of biological identity (what counts as one individual organism, and what makes each individual organism “the same” though it constantly changes through time?) has a long history both in philosophy and in science. Recent data coming from immunology, microbiology and developmental biology may revolutionize our conception of the construction of biological identity through time, by showing that this construction depends crucially on environmental factors and, most importantly, on a constant dialogue with symbiotic microorganisms integrated into the organism. IDEM, a fundamentally interdisciplinary project at the interface between philosophy and biology, aims at: i) determining to what extent it is adequate to see this shift as an ongoing “microbial revolution” in today’s biology; ii) understanding the exact processes by which developmental processes in organisms depend on microbial symbionts; iii) asking whether the role of the immune system (usually seen as a system that rejects genetically foreign elements from the body) in the maintenance of the organism needs to be reevaluated; iv) how traditional conceptions of biological individuality will be modified by this revolution. If funded, this project will provide a new understanding of the way living things are continuously constructed through time and interact with their biotic environment.

Keywords: philosophy of biology,symbiosis,microbiota,immunity,development,identity,self
Common Interactive Objects (CIO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Denmark
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-12-01
End date: 2023-05-31
Duration (months): 66.0
Total project cost (EUR): 2398993.01
EU funding (EUR): 2398993.0
Participants: 1
Project status: CLOSED

In CIO, common interactive objects are developed and explored to extend human control over the technological environment by human beings, both individually and together. CIO leads to a coherent framework of user interfaces to be applied in interaction design. Common interactive objects will provide a useful frame for furthering human computer interaction (HCI) theory, development of interaction design methods and the underlying technical platforms. Common interactive objects will empower users to better understand and develop the technologies they use. When carried through, the project offers new ways for people to construct and configure human physical and virtual environments, together, over time and within communities. The main objectives of CIO are to 1. develop the conception of common interactive objects in order to offer a new understanding of human-computer interaction, focusing on human control. 2. develop support for building user interfaces in a coherent and unified framework. 3. make common interactive objects that will empower users to better understand and develop the technologies they use. 4. carry out ground-breaking research regarding the technological basis of common interactive objects with focus on malleability, control and shareability over time. CIO is methodologically rooted in HCI. CIO’s research methods combine empirical, analytical, theoretical, and design approaches, all with focus on the relationship between common interactive objects and their human users. CIO presents the idea that common interactive objects may radically innovate our understanding of use and building user interfaces. The gains of CIO will be a coherent new, high-impact way of understanding and building HCI across physical and virtual structures, bringing control back to the users. The risks are in delivering this alternative in a manner that is able to confront the current strong commercial interests in the Internet-of-Things and the 'new' Artificial Intelligence

Keywords: advanced user interfaces,common objects,interactive objects,control,appropriation,collaborative computing,empowering users,computer mediated collaborative activity
Multi-Scale Complex Genomics (MuG)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: e-Infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Spain,France,United Kingdom
Call: e-Infrastructures for virtual research environments (VRE) (H2020-EINFRA-2015-1, 2015)
Start date: 2015-11-01
End date: 2018-10-31
Duration (months): 36.0
Total project cost (EUR): 2961163.75
EU funding (EUR): 2961163.0
Participants: 6
Project status: CLOSED

Genomics is probably the fastest evolving field in current science. A decade ago our main concern was to obtain the sequence (the 1D code) of the genome; but today the big challenges are to determine how genotype information is transferred into phenotype, and how pathological phenotypic changes can be predicted from genome alterations. While investigating these points, we have realized that a part of the regulation of gene expression is implicitly coded in the way in which chromatin is folded. As technology has advanced and information of the folded state of chromatin has emerged, a new branch of genomics (3D/4D genomics) has emerged. Hundreds of laboratories are now defining a young and active community that, though in the end concerned with the same scientific problem, uses many different approaches to study it that individually target radically different length and timescales. The community faces severe practical problems related to: i) how huge, noisy, and diverse data related to widely different size and time scales can be integrated, ii) the lack of standardized analysis and simulation tools, iii) the complete disconnection of associated informatics databases, and iv) the lack of validated and flexible visualization engines. MuG is born at the critical point in the evolution of the field, in a bottom-up approach from the biologist who are suffering severe IT problemes. MuG, supported by European leaders in the field, join three different expertise: biologist with interest in chromatin structure, methods developers and HPC facilities with strong history of supporting Bio-computational problems. We believe that MuG will be a steep-forward in approaching the potential of High Performance Computing to the development of 3D/4D genomics, and will contribute to give a structure to this new and exciting field.

Keywords: genomics,computational biology,complex genomics,big data,4d genomics
Reshaping European Advances towards green Leadership Through Deliberative Approaches and Learning (REAL_DEAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Germany,Ireland,Germany,Belgium,Hungary,France,Czechia,Netherlands,Denmark
Call: European capacities for citizen deliberation and participation for the Green Deal (H2020-LC-GD-2020-4, 2020)
Start date: 2022-02-01
End date: 2025-01-31
Duration (months): 36.0
Total project cost (EUR): 6795550.0
EU funding (EUR): 6795550.0
Participants: 17
Project status: SIGNED

REAL_DEAL will stimulate a pan-European debate to reshape citizens? and stakeholders? active participation through deliberative processes around the European Green Deal. It brings together researchers and practitioners of deliberative democracy from a wide range of disciplines including environmental rights and the law of public participation, ethics and responsible innovation, gender studies and ecofeminism, psychology, geography, urban planning and sustainability studies. It includes the EU?s largest civil society networks advocating on the environment, climate, sustainable development, local democracy and the European movement. It teams up with youth climate, social justice and women?s organisations, SMEs, universities and research institutes, mobilising networks with thousands of CSOs, uniting millions of citizens and activating contacts to thousands of policymakers. In a large co-creation exercise, REAL_DEAL will develop, test and validate innovative tools and formats to propel deliberative democracy to the next level. It will tests its innovations at citizens assemblies for the transition in at least 13 countries. We will scrutinise pan-European formats ranging from digital deliberation through our online platform www.CitizensGreenDeal.eu to in-person processes such as an Assembly for a Gender-Just Green Deal and a pan-European Youth Climate Assembly. REAL_DEAL will co-create a comprehensive protocol for meaningful citizens? participation and deliberation to work towards the objectives of the EGD. It will validate recommendations on how to design such processes and how they can be applied by European institutions, Member States and civil society alike. Gender equality will be embedded into the project?s DNA. It pays specific attention to the leave-no-one-behind principle, fostering the engagement of disenfranchised groups that are disproportionally burdened by environmental damage. REAL_DEAL will develop a new model of environmental citizenship across Europe.

Keywords: sustainable development,environmental justice,gender equality
Intellectuals in History: Political Process and Cultural Impacts in Medieval Europe (14th and 15th centuries) (INSPIrE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

The principal aim of INSPIrE is to create a picture of the relationship between politics and written culture in 14th and 15th century Europe, focusing on the Franco-German and Italian geographical areas. INSPIrE will answer several questions which have arisen regarding the link between intellectual production and major historical events, such as: which are the most relevant historical events for written culture? Can a philosophical treatise influence politics? How many women write political texts? The project aims to identify the development lines, breaking points, peculiar cases and matching patterns of the relationship between politics and written culture, reckoning with five key features: the combination of events, places, times, languages, gender and literary genres will allow us to map the networks of texts linked to historical events. In the first phase, data concerning texts linked to the historical events selected as relevant - four case studies are planned - will be gathered and arranged according to the five key features. In the second phase of the research, the analysis of collected and arranged data will produce the expected results. The bottom-up methodology, based only on concrete data, the synchronic and diachronic approach and the text/context connection are the most innovative elements of INSPIrE. The project represents an excellent topic for Medieval Studies and also constitutes a ground-breaking chance to fill the gap between past and present, since it clarifies the roots and history of the connection between politics and culture in Europe. Moreover INSPIrE addresses the guidelines of the Horizon 2020 Work programme 2016-2017: the project will promote interdisciplinary cross-fertilization to overtake the separation among SSH disciplines and better understand historical and cultural phenomena. INSPIrE will also use an innovative approach to research training, with special focus on the gender dimension in research contents.

Keywords: history of political thought,medieval philosophy,vernacular literature,gender studies
Role of YAP/TAZ on Circulating Tumour Cells (RYTAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Metastasis is the leading cause of all cancer-related deaths. Circulating Tumour Cells (CTCs) are cancer cells that shed off the primary tumour, enter into blood vessels and through the blood circulation are transferred to distant organs, whereby they establish new metastatic lesions. CTCs are detected as single cells and/or clusters of cells with clusters being more metastasis-prone than single CTCs. CTC clusters have different sizes varying from 2- to 50-cells. However, it still remains unknown if the different size of CTCs has an impact on their metastatic potential and what factors regulate their size. To elucidate the molecular dynamics of clustered CTC formation, we performed RNA-seq analysis in cells from primary tumours and CTCs and identified the YAP/TAZ gene signature to be upregulated in CTCs. YAP/TAZ is an interesting molecular node, as its function depends on its subcellular localisation. Junctional localised YAP/TAZ inhibits cancer cell dissemination by supporting the maintenance of cell-cell adhesions, while nuclear YAP/TAZ induces a genetic program that promotes cancer progression. We hypothesised that YAP/TAZ could play a critical role on CTC biology, regulating the size and metastatic potential of CTCs. Thus, the aim of this fellowship is to determine the impact of the size of clustered CTCs on establishing metastatic lesions and provide mechanistic insight on the role of YAP/TAZ. More specifically, I will determine: 1) the localisation of YAP/TAZ in CTCs from mouse models and patients with breast cancer, 2) if YAP/TAZ affects the size of clustered CTCs in breast cancer mouse models, 3) if YAP/TAZ localisation affects the metastatic potential of CTC clusters of variable sizes and 4) signals regulating the nucleocytoplasmic shuttling of YAP/TAZ in CTCs. Hence, this research could be the foundation for developing novel anticancer therapies and an improved patient stratification system.

Keywords: metastasis,circulating tumour cells,breast cancer,taz signalling
European paths to transnational solidarity at times of crisis: Conditions, forms, role-models and policy responses (TransSOL)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Switzerland,Greece,Poland,France,United Kingdom,Denmark,United Kingdom,United Kingdom
Call: European societies after the crisis (H2020-EURO-SOCIETY-2014, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 2847680.0
EU funding (EUR): 2483805.0
Participants: 11
Project status: CLOSED

TransSOL is committed to the systematic, interdisciplinary and praxis-oriented analysis of European solidarity in times of crisis. It has three overarching objectives: (a) it will map and analyse solidarity in Europe by means of a cross-national database that comprises three surveys addressing the general population, organized civil society, and claims-making in the media; (b) it will gather systematic data on the contextual factors and engage into political and legal analyses to ascertain the influence of the socio-economic, political, and legal context on solidarity, in particular the impact of the crisis, the EU’s political responses and target-groups specific public policies; and (c) it will identify and develop best practices of transnational solidarity, draft evidence-based policy recommendations, and engage proactive dissemination and communication activities. The project comprises teams from Denmark, France, Germany, Greece, Italy, Poland, Switzerland and the UK, including scientists from various disciplines and civil society practitioners, thus promising to deliver interdisciplinary and comparative analyses, knowledge-transfer and evidence-based, practicable recommendations. The project will enable us to address the three topics of the call. First, TransSOL will provide the first rigorous and comprehensive analysis of transnational solidarity in Europe, its main forms, conditioning factors (e.g., individual features as gender and social class, spatial inequalities, and contextual factors), and underlying conflicts about contending norms, identities, and interests. Secondly, the project will address the impact of Europe’s cultural diversity and multiple identities on European solidarity by analysing public claims-making and debates within the media. And finally, we engage into a critical reflection about adequate policy responses, in particular about the potentials of social investments balancing civic virtues of solidarity with public responsibilities.

Keywords: transnational solidarity,crisis,social innovation,alternatives,best practice,civil society,public sphere,claims making,public policies,policy responses,social investment