Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
“Thomas Aquinas’ Summa Theologiae Ia IIae translated by Demetrius Cydones and Bessarion’s incomplete Compendium of the translation – A Critical Editio Princeps” (TASTGCEP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-03
End date: 2018-10-02
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The proposed Project is the critical edition (editio princeps) of the Greek translation of Thomas Aquinas’ Summa Theologiae Ia IIae by Demetrios Cydones and of its partial Compendium by Cardinal Bessarion. The proposed research is part of the “Thomas de Aquino Byzantinus” Project, which is held by the Royal Holloway University of London and the Department of Education of the University of Patras. This project aims to provide scholarship with critical editions of the Byzantine translations of some of Aquinas’ writings and, thus, to contribute to the research on the relations between the Catholic and Orthodox theological and intellectual traditions. As regards the proposed research, just a few studies deal with the influence of Scholastic moral philosophy on Byzantium. Thus, the proposed critical editions will reveal the influence of Thomas Aquinas’ moral philosophy on Byzantine world and shed more light on the philosophical and theological dialogue among distinguished scholars and theologians in the Greek East and the Latin West in a period of intensive intellectual creativity. In this aspect, the relations between the Latin and Byzantine culture will be seen from a different point of view and the History of Ideas in Europe will be enriched. In this sense, the publication of these texts will become an indispensable tool for scholars and students of Byzantine and Western European intellectual history. Considering the quality of the proposed research, my competences in critical editions, and my research experience on Byzantine Thomism, I firmly believe that the proposed Project is the appropriate next step in my career development. For this reason, I decided to apply for MC – IF, since this Fellowship will give me the opportunity to join an excellent Department in the field of Byzantine studies (Department of Humanities, UNIVE) and produce a voluminous edition, which is estimated to reach 900 pages.

Keywords: the proposed project is the critical edition of the greek translation of thomas aquinas summa theologiae,ia iiae by,demetrios cydones and the partial compendium of this translation by cardinal bessa
Cross-talk between inflammation and autophagy in tuberculosis (Inflammafish)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-18
End date: 2018-01-17
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

The increasing occurrence of multidrug-resistant Mycobacterium tuberculosis strains makes tuberculosis (TB) a key priority for infectious disease research. Inflammation and autophagy are two fundamental processes critical to TB pathogenesis. Accumulating evidence shows that TB disease is worsened by deregulation of the inflammatory response. On the other hand, autophagy has recently emerged as a crucial host defence mechanism. Autophagy counteracts the ability of mycobacteria to survive inside host cells and targets them for degradation. Autophagy is also thought to control the inflammatory response. However, the interaction between inflammation and autophagy in host defence against TB remains unclear. The aim of my proposal is to use the well-established zebrafish model of TB to gain insight into this key question. Recently, the host laboratory discovered that the DNA damage-regulated autophagy modulator (DRAM1) protects against TB in the zebrafish model. They also implicated this important autophagy regulator in inflammation, as it strongly affects expression of interleukin-1beta (IL1B). I have specific expertise in studying IL1B-mediated inflammation in zebrafish. Thus the proposed project will be a great synergy between me and the host laboratory, which is leading in zebrafish infectious disease research. I will determine how modulation of autophagy or manipulation of IL1B levels reciprocally influence each other during TB disease. The zebrafish model provides excellent tools to visualize these processes in vivo. Furthermore, I will take advantage of the host’s expertise in RNA sequencing and proteomics to study genome-wide effects of autophagy modulation on the inflammatory response. A secondment will allow me to compare results in the TB model with a damage-induced inflammation model. The project will provide new insights into regulatory pathways that could potentially be intervened in treatment of TB or other inflammatory diseases with common characteristics.

Keywords: infection,tuberculosis,host defence,zebrafish model,anti bacterial autophagy,inflammatory response
Innovative cancer management: First in human senescence imaging (SenPET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The irreversible growth arrest, termed cellular senescence, plays a key role in tumor progression and promotion, as well as in many other physiological processes. It has been shown to be a predictive marker for the long term outcome of cancer treatment and novel therapies aiming at the elimination of senescent cells are under development (i.e. senolytics). Therefore, techniques for the detection of senescence are of utmost importance. However, in the current clinical setting this is only possible with histological staining after collection of invasive biopsies and a tool for non-invasive assessment and quantification of senescence is highly desirable towards improved patient care and personalized medicine. Within our current ERC project ImageLink we have developed a stable and reproducible synthesis protocol for a novel radiolabeled PET-tracer targeting ß-galactosidase, the “gold-standard” biomarker of senescence. The tracer was validated in several in vitro and in vivo human and murine tumor models. A clear distinction between senescent and non-senescent tumors was possible and the convincing results have encouraged us to translate our preclinical findings into a clinical setting. However, this step exceeds the scope of our current ERC project. Within the planned project SenPET we will establish an automated radiosynthesis of the tracer that is compliant with good manufacturing practice (GMP) and all necessary paperwork with the authorities for approval of a clinical study will be accomplished. Finally we will perform the first clinical proof of concept study of a senescence PET tracer in 10 patients suffering from gastrointestinal tumors. PET data with our novel tracer will be collected before and after a senescence inducing chemotherapy treatment and correlated with ex vivo markers of senescence. Since our tracer is protected by patent applications, the results of this study will help us to team up with industrial partners to perform larger clinical studies.

Keywords: tumor senescence,personalized medicine,theranostics,senescence monitoring by pet imaging,personalized medical treatment of cancer
EKOGRID™, the first technology to clean water and underwater sediments with electrokinetic oxidation (EKOGRID)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: SME instrument
Countries involved: Finland
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-01-01
End date: 2018-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The presence of pollutants in fresh, ground and seawater threatens wildlife and ecosystems and raises concerns for public health. Water pollution indeed not only puts biodiversity at risk and disrupts the fragile equilibrium that exists underwater, but also affects economic activities, such as fisheries, aquaculture and tourism. Moreover, current water and seabed remediation methods cause great disturbances to the site operations and environment or use additional chemical products thus posing potential risks for the environment and increasing costs. EKOGRID™, is a patented method based on natural phenomena and reactions for water and sediment remediation. It utilizes the capacitive nature of the matrix to boost the remediation power of nature, strengthening nature’s remediation process and treating in one year sites that would have been contaminated for decades. It is a sustainable, safer and more cost-effective solution to speed up water and sediment remediation at any condition. Beyond improving water and seabed quality, EKOGRID™ also compacts the bottom sediments by reducing its water content and binds nutrients to the seabed avoiding eutrophication and algae growth in seawater, coastal ponds and lakes. To date, we have invested €2.5M into the development and testing of our test to ensure its robustness and efficiency and move into the commercialisation stage. This technology has already demonstrated its performance and efficiency in soil and ground water remediation. Within the overall project, we intend to translate the technology into water and seabed applications. The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of EKOGRID™ and its market uptake.

Keywords: oxidation,electrokinetic,remediation,bioremediation,sediments,water,soil
Generation of Position Specific organoids to study human neuromuscular system development and disease (GPSorganoids)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2799375.0
EU funding (EUR): 2799375.0
Participants: 1
Project status: SIGNED

Locomotion results from the interaction between muscles and the nervous system. Dysfunction of such cells results in deadly diseases such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). These diseases often show regional selectivity but the underlying reasons remain obscure due to the lack of a suitable model system. In previous work of my laboratory, we established a 3D neuromuscular organoid (NMO) model that allows the simultaneous generation of spinal cord neurons and skeletal muscle cells from human pluripotent stem cells (hPSCs) through a bipotent neuromesodermal progenitor (NMP). NMPs, located in the posterior part of the embryo, are driving axial elongation and coordinated growth of the trunk neuromuscular system. We coaxed hPSC derived NMPs to develop into neuromuscular organoids that form functional neuromuscular junctions supported by the presence of terminal Schwann cells and central pattern generator-like circuits. Thus, we are in the unique position to study in an organoid model the regulatory mechanisms involved in the formation and maintenance of the human neuromuscular system, and the disruption of these mechanisms in diseases. We will (i) identify the molecular requirements for the Generation of Position Specific (GPS) organoids representing distinct spinal cord segments, (ii) use NMOs to model and study ALS and SMA including the establishment of a drug screening platform and (iii) assemble hPSC-derived cerebral organoids and NMOs to include in the model human corticospinal tracts. In the long term, the information gained will have important implications for understanding and eventually treating neuromuscular diseases.

Keywords: neuromuscular organoids,nmos,neuromuscular system development,hox genes,neuromuscular diseases,neuromuscular junction,spinal cord organoids
MAPPING THE SKIN-IMMUNE INTERACTIONS OF NOVEL 2D MATERIALS: MXENES (SEE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2024-06-30
Duration (months): 36.0
Total project cost (EUR): 251002.56
EU funding (EUR): 251002.56
Participants: 2
Project status: SIGNED

Two-dimensional (2D) transition metal carbides/carbonitrides (MXenes), discovered by the outgoing phase Supervisor, Yury Gogotsi (H-index = 160), at Drexel University (USA), have stepped into the limelight of 2D materials (2DMs). Within the SEE project, the Fellow, Dr. Laura Fusco, will learn to produce and characterize MXenes from the most recognized leader in the field. SEE will provide a thorough evaluation of the skin impact and possible immunomodulation of a wide variety of MXenes. No study has investigated at the same time and on a large scale these key aspects for MXene safety and effective use as bioelectronics or biomedical tools applied to the skin. The outstanding peculiar scientific expertise of the Fellow, relying on the characterization of 2DM effects at the skin level depending on their physicochemical properties, will be essential to achieve the project goals. The European Fellow Supervisors, Bengt Fadeel and Lucia G. Delogu, among the most influential scientists in the field of nano-immunology and toxicology, will contribute to the Fellow training by employing the most cutting edge high-dimensional technologies at the single-cell level (e.g., CyTOF, Rhapsody and Hyperion) and pioneering cell-cell analysis systems (e.g. LIPSTIC approach) in this context. The Fellow will also explore the commercial applicability of her results during a secondment at the revolutionist biotech company Fluidigm Corporation. Within SEE, the Fellow will introduce her own novel concept of “Nano-SkinImmunity-by-design”, where the analysis of the cutaneous effects when designing MXenes (and 2DMs) will not only be relevant for their safety, but will also turn them into active tools for cutaneous applications endowed of immune properties, tailorable adjusting their physicochemical profile. By exploring these crucial aspects, SEE aims at incising the strategic field of MXenes and 2DMs as well as their role in biomedicine and nanotechnology at European level and beyond.

Keywords: mxene,2d materials,nanotoxicology,nanomaterials
Discontinuities in Household and Family Formation (DisCont)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Italy,United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-02-01
End date: 2022-07-31
Duration (months): 66.0
Total project cost (EUR): 2400555.0
EU funding (EUR): 1977500.0
Participants: 2
Project status: SIGNED

Household, family and fertility changes are key drivers of population dynamics. Discovering and explaining the velocity of these changes is essential to understand the current situation and to provide scientific evidence on our demographic future. DisCont will provide seminal contributions by studying the impact of macro-level discontinuities on household and family formation (including fertility) in post-industrial contemporary societies. In the past decade, two macro-level discontinuities have radically transformed lives: the Great Recession and the digitalization of life and of the life course. Although their short-term and long-term impacts are likely to be fundamental, they have not yet been systematically analysed. Through a coordinated series of theoretically-founded empirical studies based on linked macro- and micro-level data, and using a comparative perspective, DisCont will argue that macro-level discontinuities are crucial in explaining broad changes in household and family formation, and that their effects can be persistent either for the population as a whole, or for specific cohorts. DisCont will contribute to five areas: 1) it will make theoretical advances by showing the importance of macro-level discontinuities in the explanation of changes in household and family formation in particular, and in population dynamics in general; 2) it will substantially advance our knowledge of household and family formation in post-industrial contemporary societies; 3) it will contribute in a systematic and path-breaking way to research on the broader societal impact of digitalization and of the Great Recession; 4) it will bring a paradigm shift in Age-Period-Cohort modelling; 5) it will make ground-breaking contributions on the demographic use of “big data” and on the use of agent-based models for the population-level implications of household and family change.

Keywords: life course,great recession,digitalisation of life,transition to adulthood
Analysis of sugar- and osmo-signalling mechanisms in cell wall integrity maintenance (SugarOsmoSignalling)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-16
End date: 2018-03-15
Duration (months): 24.0
Total project cost (EUR): 208400.4
EU funding (EUR): 208400.4
Participants: 1
Project status: CLOSED

Cell walls provide plant cells with structural support during growth and differentiation as well as with protection against environmental stress. Cell wall composition and structure is adapted to these functional requirements by a dedicated mechanism to maintain cell wall integrity (CWI). The available evidence suggests that the CWI mechanism is an important regulator of cell wall and carbohydrate metabolism and that signalling of sugar levels and osmotic conditions is vital for its function. Furthermore, interdependencies between pathogen defence and the CWI mechanism are becoming apparent. By performing a forward genetic screen in Arabidopsis, I will identify novel components involved in sugar-signalling in the context of CWI maintenance and pathogen defence. Using a combination of genetic mapping and next-generation sequencing, I will determine the identity of the components, whose specific activities will be identified through targeted functional analyses. In the second part of my project I will determine functions of the signalling metabolites trehalose-6-phosphate and glycerol-3-phophate in CWI maintenance and analyse the osmo-sensitive regulation of these functions. After characterizing time-dependent quantitative changes in metabolite levels and related enzyme activities upon impaired CWI and in combination with osmotic support, I will examine specific functions of metabolites / enzymes by analysing developmental, hormonal and structural responses in Arabidopsis overexpression and knockout lines. This project takes advantage of CWI maintenance involvement in a variety of biological processes to identify signalling components and osmo-sensitive mechanisms for the coordination of carbohydrate metabolism with cell wall metabolism and pathogen defence. The knowledge generated in this project will provide novel functional insights into metabolic processes relevant for facilitating bioenergy production and increasing the yield of food crops.

Keywords: plants,cell wall,carbohydrate metabolism,signalling,plant pathogen interaction
Evaluating a Combination of Immune-based Therapies to Achieve a Functional Cure of HIV Infection (HIVACAR)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Spain,Spain,Belgium,Belgium,France,France,United States,Denmark,Canada,Luxembourg
Call: New therapies for chronic diseases (H2020-SC1-2016-RTD, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 6822299.13
EU funding (EUR): 6685111.0
Participants: 19
Project status: SIGNED

The main goal of HIVACAR proposal is to change the current paradigm of HIV treatment by obtaining a functional cure for HIV (i.e., control of viral load to levels below the threshold of 50 copies/ml and maintenance of high CD4+ T-cell count after discontinuation of antiretroviral therapy) thanks to effectively targeting residual virus replication and viral reservoirs. In order to do so, the planned novel strategy is to successfully combine immune-based therapies, including therapeutic vaccines and broadly neutralizing antibodies with latency reversing agents, in a proof-of-concept phase IIa clinical trial. HIVACAR project will lead to a reduction of the actual costs related to HIV treatment and management and of the social public health as well as an improvement in the patients’ quality of life. HIVACAR project has been conceived under the framework of responsible research and innovation, so patients and other stakeholders will have a key role from the inception of the project until obtaining the results. Patients will be perfectly aware of how this therapy has been conceived and the real impact and change in their actual quality of life, as well as how the clinical trial has been designed and the consequences of participating in it. In addition, patients (and the general population) will tailor the project and its results dissemination and communication. This patient engagement will not be limited to the clinical trial but also to the rest of the activities of the project, so patients and the general society will be aware of how the research is developed and can include the patients’ point of view in the research activities. In addition, the socio-economic and psycho-social impact of the new treatment will be also analysed so overwhelming data on the benefits and impact of the new treatment will be obtained and shown to all the stakeholders.

Keywords: personalised vaccines