Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Continual Acoustic Based Multifunctional Cage Mounted Fish estimator Deigned To Reduce Feed Waste, Fish Mortality, and Predator and Fish Escape Control (Fishtimator)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: United Kingdom
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The growing demand for sea food has resulted in the depletion of natural fisheries and it is estimated that 62% of the sea food will come from aquaculture farms by 2030. The profitable operation of aquaculture farms is being hindered by unbalanced and un-predictive fish feed amount, unreliable biomass estimation, fish escape and fish mortality. Fish feed alone represents 50% of the total operating costs of the fish pans and cages. Permanent and accurate estimation of fish size and weight is of significant importance in the fish farming industry for the provision of key data with which feeding, grading and harvesting operations are controlled. Ocean Tools Aquaculture (OTAQ) is an industry leader in providing predator control and acoustic technologies for the aquaculture industry. Our solution is to develop an acoustic based permanent in-cage biomass estimator system (FISHSTIMATOR) that will deal with the problems being faced by aquatic fish farmers. The solution is intended to reduce fish feed waste by 3-5% by giving recommended amount of feed that matches the number of fish and their growth rate. Fish mortality and escape due to predators, anomalies in the cage structure and thieves will be eliminated by close monitoring of the cage environment. FISHSTIMATOR will be sold to farmers at €26’000 per cage and leased for €13’000 per cage. With this pricing model we envisage to clinch to 16% of the global aquaculture monitoring market which is estimated to reach €5.24 billion at a compound annual growth rate of 5.24% by 2020 (3% of €175billion - global aquaculture market) and increase our revenue from €2.5M to €84M by 2022. In Phase 1 we will validate FISHSTIMATOR prototype, develop Intellectual Property strategy, and carry out a market study, search and recruit partner and draft a business plan in a period of 6 months. In Phase 2, we will finalise the design and operability of FISHSTIMATOR allowing us to match the requirements of the targeted customers. The prototype dev

Keywords: in cage fish biomas estimator for fish farmimg
Development of an innovative and resource-efficient starter culture for the baking industry to enhance flavour diversity (Vinarom)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The European bakery industry is a stable, high-volume market with ca. 1,000 industrial bakeries in Europe and thousands of artisan bakeries (e.g. 13,700 in Germany) supplying consumers with roughly 39 million tons of bread yearly. Nearly every European bakery had its own designated yeast strain cultivated in the beginning of the 19th century resulting in a broad variety of aroma and taste. Today, besides sourdough all wheat bread is prepared without exception with S. cerevisiae as leavening agent leading to a market volume of €3.8 billion concentrated on a single yeast species. While the wine and beer industry take advantage of the innumerable yeast species commercially available, the baking sector is still sleeping on the opportunity to re-evaluate our most consumed food with variety. As a solution, our company OPTIFERM has successfully developed Vinarom®, an organic, bio-certified leavening agent based on Torulaspora delbrueckii. Vinarom® as high performing and reliable yeast blend, is cultivated with side-streams of the food industry enabling us to be independent of the price fluctuations of the conventional substrate molasses. Our in-house developed toolbox for the precise assembly and cultivation of yeast blends will introduce region specific Vinarom® varieties resurrecting past flavour sensations in bread and promote lost taste diversity. Vinarom® will generate high revenues in the targeted markets of bio-certified, organic bakeries with a targeted market share of 7% within 7 years after the end of the project. This ambitious target is reachable by forming a European network of regional producers and customers, using suitable models of Joint Ventures and/or licensing agreements. The production costs have been estimated with 1.20 €/ kg in the first three years and with rising production the costs will be reduced to ca 0.92 €/kg. The sales price will be in the range of 1.60 €/kg (ca. 40 profit range). 10% of the annual turnover will be reinvested in our R&D.

Keywords: flavour diversity,bakery sector,fermentation
Metabolic Drivers of Epigenetic Modifications: metabolic inducers of histone post-translational modifications in a biological setting (M-DrivE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Slovenia
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 157287.6
EU funding (EUR): 157287.6
Participants: 1
Project status: CLOSED

Post-translational chemical modifications to histone proteins – the storage units of DNA – influence gene expression electrostatically and through specific protein-protein interactions, the study of which is known as epigenetics. Although many enzymes have been identified which add, remove or recognise these modifications, the implication of metabolism in the induction of epigenetic states is a recent development – particularly highlighting acetyl coenzyme A (CoA) as the sole donor for acetylation. Due to the lack of appropriate biochemical tools, this emerging field has not yet been exploited, however Acies Bio’s leading work on the efficient synthesis of 4’ phosphopantetheine (4-PPT), a natural precursor of the prolific substrate CoA, places us in a unique position to realise the novel approach of metabolically inducing epigenetic modifications. In progress towards therapeutic use bypassing faulty metabolism in a rare genetic disorder, we have shown that 4-PPT is cell permeable, serum-stable, tolerated at high doses without side-effects, and can also upregulate histone acetylation. This presents a previously unexplored route to develop 4-PPT as a novel vehicle for the delivery of diverse intracellular acyl-CoA species, and subsequent histone modification. Taking advantage of the interplay between metabolic and epigenetic states, and the complementarity of backgrounds that Acies Bio and Dr Sekirnik can provide through an international partnership combining expertise in both fields, our proposed work would illuminate recently characterised histone acylations. By synthesising novel 4-PPT derivatives, and demonstrating their activity on a cellular and model organism level, we will develop new tools to enable rapid enrichment of rare endogenous modifications to probe their function. This would form the first demonstration of use of native enzyme substrates to affect epigenetic states, affording new European research opportunities in both metabolomics and epigenetics.

Keywords: chemical biology tools,metabolic induction,enriching natural epigentic modification
Epigenetically Stable Cloned Plants: Increasing The Epigenetic and Phenotypic Diversity of Plants through Tissue-Specific Regeneration (Epi-Somaclone)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Most of phenotypic variation comes from variation in DNA sequence. However, a number of studies have clearly shown that phenotype variation and diversity can also be the result of epigenetic changes. The major goal of this proposal is to develop a novel methodology for robust production of epigenetically stable plant variants, in order to increase epigenetic and phenotypic diversity. A key element in the project will be a recent breakthrough in the generation of clonal individuals from different tissue types using inducible overexpression of the embryonic regulatory protein RKD4. Preliminary work shows that plants regenerated from roots inherit many aspects of root specific methylation and gene expression patterns, even in the leaf tissue. Importantly, these features are stably transmitted across generations. For this project, I propose to: (1) evaluate physiological consequences of altered epigenomes in RKD4 regenerated plants; (2) compare (epi)genomic and phenotypic variation between plants regenerated using hormones and RKD4 overexpression; (3) compare epigenomic and phenotypic consequences in regenerants of different Arabidopsis thaliana accessions and close A. thaliana relatives Arabidopsis lyrata and Capsella rubella. The program, which will be carried out under supervision of Detlef Weigel, a world leader in plant genetics and genomics, will substantially contribute to increasing the toolkit for plant breeders to generate meaningful phenotypic diversity.

Keywords: arabidopsis thaliana,regeneration,epigenetic variations,natural variations,phenotype diversity
Improving resilience of sensitive industrial plants & infrastructures exposed to cyber-physical threats, by means of an open testbed stress-testing system (InfraStress)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Protect and improve the resilience of critical infrastructures, supply chains and tranport modes
Action type: Innovation actions
Countries involved: Germany,Italy,Ireland,Ireland,Italy,Germany,Germany,Israel,Cyprus,Belgium,Poland,Greece,Slovenia,Slovenia,Greece,Greece,France,Portugal
Call: Prevention, detection, response and mitigation of combined physical and cyber threats to critical infrastructure in Europe (H2020-SU-INFRA-2018, 2018)
Start date: 2019-06-01
End date: 2021-09-30
Duration (months): 28.0
Total project cost (EUR): 10137673.75
EU funding (EUR): 7999622.88
Participants: 27
Project status: CLOSED

InfraStress addresses cyber-physical (C/P) security of Sensitive Industrial Plants and Sites (SIPS) Critical Infrastructures (CI) and improves resilience and protection capabilities of SIPS exposed to large scale, combined, C/P threats and hazards, and guarantee continuity of operations, while minimizing cascading effects in the infrastructure itself, the environment, other CIs, and citizens in vicinity, at reasonable cost. In fact, InfraStress will develop TRL4+ solutions from preceding research and innovation towards TRL7 level producing maximum adoption of the proposed methods and solutions. Addressing the current fragmentation of available security solutions and technology, InfraStress will provide an integrated framework including cyber and physical threat detection, integrated C/P Situational Awareness, Threat Intelligence, and an innovative methodology for resilience assessment – all tailored to each site. InfraStress adopts a user-driven approach carried out through: a) delivery of usable and user-friendly Services and Applications for C/P protection and resilience; b) technical activities driven by and receiving active input from end users, i.e. SIPS and relevant stakeholders; c) a comprehensive set of 5 real-world Pilots and Evaluation activities to be carried out by User partners. InfraStress matches key impacts not only in response to the Work Programme Call but also at Strategic, Socio-economic and Market levels. In fact InfraStress was conceived since the beginning with a strong business vision in mind and will carry out effective exploitation actions ensureing successful go-to-market. Tailored activities are also planned to rise a a culture of participatory security to involve all stakeholders including companies, workers, public authorities, citizens and civil society. InfraStress involves 27 partners of excellence from 11 countries with very cross-cutting and complementary competences and excellent track records, including 5 SIPS operators.

Keywords: situational awareness,eu culture of security and cip,threat intelligence,resilience
Camouflaging electronics in the brain with immobilized liquid coatings (BRAIN CAMO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

In the UK alone, those suffering from brain disorders is approximately 45 million and associated healthcare costs exceed 130 billion euros per year. Neural electronics for recording and stimulating brain activity have become invaluable tools to study and treat disorders such as epilepsy, depression, and Parkinson’s. Currently used neural probes often fail in chronic evaluations (>1 year); the stiffness and chemistry of probes induce inflammation, neuronal death, and fibrous capsule formation. When examining a neural probe, the vast majority of the surface area is comprised of the encapsulation material; an insulating polymer that shields electronics from tissue. To date, most studies of implantable electronics have utilized only bare insulation as the tissue-interfacing material, yet in long-term studies, these insulation materials degrade and crack from the in vivo environment and expose the underlying electronics. Furthermore, adherence of proteins and cells to insulation promotes the immune response against the probe. Therefore, introducing an effective barrier between insulation and tissue is a highly promising approach for improving probe biocompatibility and performance. In this proposal, the approach is to use water-immiscible liquids anchored to the surface by a gel to shield neural probes from surrounding tissue. The proposed strategy of these immobilized liquid coatings (ILCs) is applicable to all implantable electronics, including those for other tissues and those based on various materials (silicon, metal, and organics). This proposal will focus solely on organic probes, which can be flexible and have recently been shown to improve biocompatibility by the reducing the mechanical mismatch between probe and brain tissue. Therefore, applying ILCs to organic neural probes will advance the current state-of-the-art and will address chronic biocompatibility on multiple fronts.

Keywords: bioelectronics,implantable electronics,neural probes,biocompatibility,organic electronics
From boreal spring to summer Tropical Atlantic inter-annual variability (FESTIVAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-16
End date: 2021-01-15
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

The economy of tropical Atlantic countries is based, to a large extent, on agriculture and fisheries, which are highly climate-dependent. Moreover, climate variations affect the incidence and transmission of certain diseases (i.e: Malaria), which strongly impact on the health and livelihood of West Africa and South America populations. Consequently, the tropical Atlantic variability (TAV) has important environmental and socio-economic impacts. Two dominant air-sea coupled patterns govern the TAV: the Meridional Mode (MM) and the Equatorial Mode (EM). The MM presents an inter-hemispheric sea surface temperature (SST) gradient during boreal spring, while the EM is characterized by warmer (cooler) SST anomalies in the eastern equatorial Atlantic in boreal summer.FESTIVAL project aims to investigate the existence of the MM-EM connection from a novel non-stationary approach. The air-sea processes responsible of this interaction will be determined at different time scales. The MM and EM have profound imprints on the climate of adjacent and remote areas. If the MM-EM connection is established, their individual climate teleconnections would change, impacting on the precipitation anomalies over South America and Sahel, on the strength of the Northwest African and Angola-Benguela upwellings and on the Euro-Mediterranean climate. Moreover, the MM would act as a precursor of the EM pattern, enhancing its predictability, which still remains a challenge for the scientific community. Thus, within FESTIVAL, we will investigate the climate impact of the MM-EM link and will assess the predictive skill of the EM from the tropical Atlantic spring variability. The natural decadal variability and the externally-forced Global Warming could modify the background state, modulating the TAV and in turn the MM-EM connection. In FESTIVAL, we will properly assess the role played by the low-frequency variability in the key mechanisms for activating the MM-EM connection.

Keywords: tropical atlantic variability,climate teleconnections,predictability,natural variability,global warming
Multiscale Dynamics with Ultrafast High-Resolution Relaxometry (HIRES-MULTIDYN)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Switzerland,Poland,France,France
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 3284779.99
EU funding (EUR): 3284779.99
Participants: 8
Project status: SIGNED

The properties of individual molecules and condensed matter are at the origin of the functions of almost every single product conceived, produced or analysed. Understanding and improving the properties of condensed matter requires the determination of both structure and dynamics with atomic resolution over a very broad range of timescales. No technique is available today to determine dynamics from picoseconds up to microseconds of complex systems in liquids with atomic resolution. The HIRES-MULTIDYN project introduces a ground-breaking technology: ultrafast high-resolution relaxometry (UHRR), which synergizes the high-resolution power of high-field nuclear magnetic resonance with multiscale dynamics low-field relaxation based on a new concept for critical fast-field switching. We will design, build, and test the first two proof-of-concept prototypes of UHRR instruments. We will develop the theoretical framework to understand the unprecedented measurements obtained by UHRR and interpret them in terms of molecular motions. We will exploit UHRR prototypes in a series of proof-of-concept applications covering a broad range of fields (drug design, food and health sciences, energy). These applications will demonstrate the unprecedented analytical power of UHRR and generate the momentum required to lead to the future development of a commercial UHRR system built in Europe. The HIRES-MULTIDYN project brings together a tight and complementary consortium of engineers, experimental scientists and theoreticians who are world leaders in NMR methods development, instrumentation, applications and in the theoretical foundations of magnetic relaxation and molecular dynamics simulations. Our ambition is to develop UHRR as a novel technology to determine the dynamic properties of condensed matter that will, within the next decade, boost the ability of scientists to innovate in academia and several industries (from pharma to food, energy and beyond) and enhance public health.

Keywords: nuclear magnetic resonance,nuclear spin relaxation,drug discovery,metabolomics,materials for energy
Cloud for Holography and Cross Reality (CHARITY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Spain,Ireland,Italy,Italy,Germany,Germany,Greece,Romania,Switzerland,Finland,Greece,Poland,Portugal,Portugal
Call: Cloud Computing: towards a smart cloud computing continuum (H2020-ICT-2020-2, 2020)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 4996175.0
EU funding (EUR): 4996175.0
Participants: 17
Project status: SIGNED

The impact of technology in the world's panorama is at an all-time high. Advanced media applications enabling immersive communication are becoming ubiquitous in our lives, and there is a global trend to adopt virtual solutions to support day-to-day business operations, social events, and general lifestyle. A subset of these innovative media applications includes Virtual Reality, Augmented Reality, and Holography, but they do not come without their share of challenges and requirements. To enable a satisfactory user experience, the requirements for the computing platform and its underlying network can be considered extreme and far from what can be attainable today. Hence, we propose a Cloud for Holography and Cross Reality (CHARITY), which is a complete framework that attempts to overcome the challenges and meet the requirements of such applications. CHARITY leverages an innovative cloud architecture that exploits edge solutions, a computing and network continuum autonomous orchestration, application-driven interfacing, mechanisms for smart, adaptive and efficient resource management, strong community involvement, and overreaching compatibility with all infrastructure vendors. This integrated framework will be put into test in a broad diversity of use cases targeted at advanced media applications, such as holographic events, virtual reality training, and mixed reality entertainment. CHARITY expects to deliver a working prototype, validated by the most demanding applications, capable of being demonstrated at dissemination events and exploited by a large community of users and companies outside the consortium, paving the way to the mass adoption of more advanced media applications in the market.

Keywords: extremely interactive and bandwidth demanding services,orchestration platform,holography,advanced media solutions