Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Functional Glycomics Through Chemoenzymatic Synthesis (SWEETPROMISE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Almost all cell surface proteins are modified by covalently-linked carbohydrates and the glycan structures on these glycoproteins are mediators of many physiological and disease processes. Despite their importance, there are no methods available to systematically and efficiently produce libraries of complex glycans to investigate specificities and biology of glycan binding proteins. To address this deficiency, we will develop chemoenzymatic technologies that can provide large collections of glycans having architectures of unprecedented complexity. It will exploit chemically modified sugar nucleotide donors that can be transferred by glycosyl transferases to give products in which artificial entities will blocks specific sites from enzymatic modification. It will provide full control over branching, sites of fucosylation, sulfation and sialylation. The chemical entities will be chosen in such a way that they can be removed after a series of enzymatic transformations. The methodology will be employed to prepare a series of keratan sulfate oligosaccharides. These glycoconjugates, which are biologically still poorly understood, have been implicated a multitude of physiological and disease processes. To further broaden the scope of the technology, a chemoenzymatic methodology will be developed to prepare sialosides that at C-4, C-7, C-8 and/or C-9 are modified by acetyl esters. The compounds will be used to develop a designer glycan microarray to identify ligands for glycan binding proteins. The focus will be on immuno-regulatory proteins and viruses that exploit cell surface glycans for infectivity. Cellular arrays will be developed to examine biological properties of hits identified in the microarray screening. The results of the studies will provide critical insight about glycan complexity and recognition by self- and viral glycan binding proteins, and will provide leads for the development of immune-modulators and antiviral agents.

Keywords: carbohydrates,oligosaccharides,enzymes,glycosyltransferases,chemoenzymatic synthesis
Surrounded by Science: Learning paths towards science proficiency (SURROUNDEDbySCIENCE)

Framework: Horizon 2020 — Science with and for Society
Action type: Research and Innovation actions
Countries involved: Israel,Italy,Belgium,Norway,Greece,France,Netherlands,Portugal
Call: Science education outside the classroom (H2020-SwafS-2020-2-two-stage, 2020)
Start date: 2021-10-01
End date: 2024-09-30
Duration (months): 36.0
Total project cost (EUR): 1897600.0
EU funding (EUR): 1897600.0
Participants: 8
Project status: SIGNED

Every day, people of all ages are engaged in powerful science-related activities outside the classroom that spark interest and foster their understanding of science. However, it is not fully understood how outcomes of such activities relate to the outcomes of traditional formal science education. Surrounded by Science brings together experts in science education research, science centers and museum pedagogues, providers of outreach and informal learning activities, strong users communities, and policy makers to design and develop a systematic assessment methodology that will analyze the impact of out-of-school science activities. The project team will conduct a series of field studies and use innovative research instruments (Digital Toolbox) to support the data collection from citizens actively participating in science related activities to assess the impact of specific out-of-school activities. The project will integrate the collected information in matrices to advise science organizations in the design of their activities. Furthermore, the project will propose an accreditation scheme for science education providers and offer guidance on their effective integration to (formal) science education policies. In total, more than 10.000 participants will become part of the assessment, either by interacting with one of the selected activities or by participation in an in-depth assessment of their science proficiency. Surrounded by Science aims to have a long-lasting impact on the ability of science educators to design more effective, targeted, and meaningful learning activities at all levels. The Digital Toolbox is available to partners within and beyond the project, allowing them to evaluate and set up more effective activities to achieve meaningful impacts on learners? science proficiency. It seeks to enable formal science education to benefit by providing schools with recommendations on how to integrate successful activities to formal learning settings.

Keywords: assessment framework,good practices,design guidelines,digital toolbox,self assessment,accreditation
Plant foods in Palaeolithic and Mesolithic societies of SE Europe and Italy (HIDDEN FOODS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Italy,United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-07-01
End date: 2021-12-31
Duration (months): 78.0
Total project cost (EUR): 1499856.0
EU funding (EUR): 1372394.93
Participants: 2
Project status: CLOSED

The role of plant foods among prehistoric hunter-gatherer societies remains one of the major issues of World Prehistory. Recovering evidence for the use of plants in ancient forager diets presents many difficulties due to the low rate of survival of organic remains. More recently, developments of various methodological tools and analytical procedures for studying the importance of plant foods in the past have started to provide means for reaching realistic estimates about the role of plant foods in early prehistoric diets. The HIDDEN FOODS project aims to further develop a suite of methodological and experimental approaches in order to (a) obtain systematic and incontrovertible evidence about the importance of plant foods in European early prehistory; (b) study causal links between plant foods processing and technological changes in artefact production; and (c) assess the role of plant foods for prehistoric hunter-gatherers’ health status. The project will take a comparative, novel and integrated approach and investigate the importance of plant foods by studying three different categories of archaeological materials: ground stone tools, macro-botanical remains and human skeletal remains. The main methodological approaches involve (a) use-wear traces analysis; (b) starch identification; (c) parenchyma tissue analysis in macro-botanical remains recovered from archaeological sites; and, (d) study of dental pathologies related to plant foods on ancient human remains. The project will examine direct and indirect evidence of plant foods for Palaeolithic (~40,000–11,600 calibrated [henceforth cal] before present [henceforth BP]) and Mesolithic (~11,600–7900 cal BP) societies of southeast Europe and Italy. The integrated approach proposed by HIDDEN FOODS for identifying the role and consequences of plant foods’ consumption in ancient foragers’ diet, technological change and health status is, to date, unprecedented in the studies of European prehistoric hunter-gatherers.
Radiation Hard Resistive Random-Access Memory (R2RAM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Italy,Italy,Germany,Finland
Call: Bottom-up space technologies at low TRL (H2020-COMPET-2014, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 1039362.5
EU funding (EUR): 1039362.5
Participants: 6
Project status: CLOSED

The project aims to realize a strong methodology for the development and design of a radiation hard non-volatile memory technology by using standard CMOS silicon processing. Since standard silicon memories, such as flash memories tend to fail under irradiation, a new approach is envisaged: the development of a specific memory technology, so called resistive random-access memory (RRAM), which is able to sustain heavy ions and other charged particles. The switching effect of RRAM devices is caused by chemical Redox-reactions, therefore, radiation effects like total ionizing dose and single event effects don’t affect the switching mechanism. Semiconductor memories, among rad hard integrated circuit scenario, are one of the most critical topics for space applications. Actually both volatile and nonvolatile memories, excluding few exceptions, are integrated using standard processes and standard architectures. This means that the final device is typically at least Rad tolerant and not Rad Hard and failure during mission is avoided using Error Correcting Code techniques including redundancy at the board level. The basic goal of the project is to give a methodology for the development of a new rad-hard nonvolatile RRAM memory with high-performance features like good retention, re-programmability and cycling, and realize a prototype (1Mbit RRAM memory) in order to validate the approach.

Keywords: resistive random access memory,cmos,radiation hardness,space applications
A SIMPLER, CHEAPER AND EASIER TO RECYCLE AEROSOL CONTAINER (Click and Spray)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2020-01-01
End date: 2020-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Aerosol containers have remained virtually unchanged since they were first invented in the 1950’s. Aerosols have multiple unnecessary components, each of which must be sourced from separate suppliers and use significant aluminium (1.58 kg/1,000 units). Multiple components means that specialized equipment is needed to assemble aerosols and slows down filling times. It also makes final products difficult to recycle with 704 million aerosols sent to landfills every year. Purple Holding has developed a completely new aerosol container, Click/Spray, that will shake up this stagnant market for the first time in over 50 years. Our radical new design doesn’t change standard components of conventional aerosols, but completely rethinks their structure to remove the need for a valve mounting cup. Our new, patented valve creates for the first time an opportunity to design endless options for new sizes and shapes. Fewer components means our products are 20% faster to manufacture and assemble, 25% faster to fill, use 5% aluminium and are easier to recycle. This saves the manufacturer €30/1,000 units and 1.5 kg of aluminium for 1,000 units for a reduced environmental impact. This gives aerosol manufacturers and the brand owners who use these products, incredible cost margins and up to 20% more revenue as well as greater control over supply.

Keywords: aerosol container,valve mounting cap,manufacturing,consumer products
Multiscale dynamics of astrophysical plasmas: pressure-anisotropy-driven instabilities and large-scale dynamical processes (ASTROMULTISCALE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The primary purpose of the proposed project is a deeper understanding of instabilities in plasmas and their influence on transport phenomena and large-scale dynamical processes. The studies will be focused on nonlinear regime of development of the firehose and mirror instabilities triggered by pressure anisotropy spontaneously generated in stellar-wind environments by large-scale expansion/compression effects and plasma turbulence. Recent studies of microphysics of the instabilities have provided systematic knowledge on saturation effects in nonlinear regime and related wave-particle interactions. This opens a possibility of investigation of a feedback between the microphysics and large-scale dynamics. The project is anticipated to provide answers to the questions: what is the effective collisionality of a pressure-anisotropic plasma that is unstable or marginally stable to the firehose and mirror instabilities and how does it change the effective pressure tensor (viscous stress) used in fluid description of plasmas? Results of the project are expected to be important for general plasma physics as related to the problem of multiscale phenomena in plasmas and coupling between microphysics and macrophysical processes. In particular, the results can help in better understanding of the dynamics of galaxy cluster plasmas, dynamical processes in stellar winds and planetary magnetospheres. The studies will be done by numerical simulations using state-of-the-art kinetic and fluid models of plasma dynamics. A numerical setup will be developed analogous to experimental setups used for classical viscosity measurements in fluids. This virtual setup will be used to measure stresses caused by development of instabilities in plasmas. A related problem of thermalization of microinstabilities into kinetic waves cascade will be also investigated. The entire modeling framework will be validated by comparison of simulation results with spacecraft measurements in turbulent solar wind.

Keywords: plasma instabilities,kinetic and fluid description of plasmas
Comparing the effectiveness and safety of additional low-dose glucocorticoid in treatment strategies for elderly patients with rheumatoid arthritis (GLORIA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Austria,Spain,Hungary,Romania,Slovakia,Netherlands,Netherlands,United States,Netherlands,Netherlands,Netherlands,Portugal,Portugal
Call: Comparing the effectiveness of existing healthcare interventions in the elderly (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-09-01
End date: 2021-08-31
Duration (months): 72.0
Total project cost (EUR): 5855219.03
EU funding (EUR): 5855219.029999999
Participants: 17
Project status: CLOSED

GLORIA aims to prove that the addition of chronic low dose glucocorticoids (GC) to current antirheumatic therapy is highly cost-effective and safe in elderly patients with rheumatoid arthritis (RA). RA is a frequent (affecting > 2% of the elderly population), painful and disabling chronic disease with high societal costs. RA is associated with multiple comorbidities, polypharmacy and adverse events; these problems, together with challenges in compliance (adherence) are dramatically increased in the elderly population. About 50% of patients are chronically treated with low-dose glucocorticoids (GC) in combination with other antirheumatic drugs, but without good evidence on the balance of benefit and harm. Thus, existing guidelines and information on safety and efficacy of GC are inadequate. GLORIA will address these problems by conducting a large pragmatic trial: 800 elderly (>65y) RA patients receiving standard of care will be randomized to additionally receive 5 mg prednisolone daily or placebo for 2 years. Very liberal eligibility criteria will ensure representativeness to the target population, and most data will be collected from routine clinical practice, minimizing patient and physician load, and operating costs. A novel tool will monitor compliance; it can send personalized reminders to a patient’s smart device. The efficacy of this technology will be tested in a nested trial. Compliance and other characteristics will be entered into a model that will allow personalized risk and benefit assessment in the future. Qualitative research in patients and physicians of member states will explore expectations and challenges in guideline implementation. This information and the study results will enable an update to existing guidelines and patient information, in collaboration with guideline committees and regulatory agencies. Networking conferences will improve health technology assessment in the elderly in general.

Keywords: rheumatoid arthritis,glucocorticoids,health technology assessment,comorbidity,compliance,cost utility assessment,pragmatic trial,tailored treatment,guideline development,patient participation
Commissioning, first tests and upgrade of a high-power S-Band Radio Frequency (RF) system for R+D of high-gradient normal-conducting accelerating cavities in breakdown science and RF conditioning (HGRF-IFIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-19
End date: 2019-05-18
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

New Radio Frequency (RF) High-Gradient (HG) knowledge and technology in normal conducting accelerator structures has been developed by the accelerator Physics community in the recent years in X-Band frequency. Significant progress has been made to understand the RF high-gradient behavior, breakdown phenomena and cavities conditioning processes, but extensive R&D is still needed in this very interdisciplinary and phenomenology research area. This project proposes the commissioning and upgrade of a novel high-power RF system in S-Band to perform systematic breakdown studies and conditioning of cavities in this frequency range, in particular interesting for medical applications. The main challenge is the implementation of a hard real-time control of amplitude and phase at microsecond scale of the pulsed megawatt RF power delivered to the structures under test. The power delivery has to be done under stringent controlled and automated conditions in order to perform the conditioning and avoid permanent damage to the structures. In addition, a power boost upgrade of the system is envisaged to reach the power limits that medical high-gradient structures need to be pushed to. A close relation with industry partners is to be carried out in order to commission the new solid-state power modulator and test structures. The outcome of this R&D project can be crucial to make more compact linear accelerators, resulting in lower cost and size, which can have a potential impact in several applications: hadrontherapy facilities based on linear accelerators, which will be emphasized in this project due to its advantageous features; industrial applications such as cargo scanning; or scientific applications such as free-electron-lasers and Compton sources.

Keywords: high gradient,radio frequency,breakdowns,linear accelerators linac,hadrontherapy,medical accelerators
Digital Fabrication and Maker Movement in Education: Making Computer-supported Artefacts from Scratch (eCraft2Learn)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Italy,Austria,Greece,Sweden,Sweden,Greece,Sweden,Sweden,Finland,United Kingdom,United Kingdom,United Kingdom
Call: Technologies for Learning and Skills (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 1943248.0
EU funding (EUR): 1943248.0
Participants: 14
Project status: CLOSED

Digital technology has radically changed the way people work in industry, finance, services, media and commerce and has urged necessary corresponding changes in educational systems. However there is a lack of progress in the education arena. Hence, recent studies show that high percentages of college graduates can't find work, the dropout rate is high and new generations are moving back into their parents homes after school or college. Nevertheless, the digital trend indicates that today's grade-school children will end up at jobs that haven't been invented yet. Nowadays, several studies assure that digital fabrication and making technologies, if coupled with proper learning methodologies such as Constructivism can provide learning experiences that promote young people’s creativity, critical thinking, teamwork, and problem solving skills, which are essential and necessary in the workplace of the 21st century. However, as early as 2008 a OECD report remarked that “technology is everywhere, except in schools”. In addition to this, most uses of technologies in education and training today do not support 21st-century learning skills. In many cases, new technologies are simply reinforcing old ways of training and learning in current school settings and very often they are introduced according to a narrow perception as being suitable only for talented youth or only for Science-, Maths- or Engineering-oriented majors. Current developments call for a move from this elitism to the recognition that fluency with making technologies represents knowledge and skills valuable for every citizen. The eCraft2Learn project will research, design, pilot and validate an ecosystem based on digital fabrication and making technologies for creating computer-supported artefacts. The project aims at reinforcing personalised learning and teaching in science, technology, engineering, arts and math (STEAM) education and to assist the development of 21st century skills that promote inclusion and employability for youth in the EU. The eCraft2Learn ecosystem will support both formal and informal learning by providing the appropriate digital fabrication, making technologies, and programming tools. It will also incorporate mechanisms for personalised and adaptive learning.

Keywords: digital fabrication,maker movement,science,technology,engineering,arts and math steam education