Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Early modern Catholic representations of Hinduism (HINDREP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-01-01
End date: 2012-12-31
Duration (months): 24.0
Total project cost (EUR): 165540.8
EU funding (EUR): 165540.8
Participants: 1
Project status: CLOSED

This two-year project is a contribution to the current post-colonial debates on orientalism and, more specifically, on the extent to which Hinduism was also a European construction. The aim is to analyze the representations that Catholic missionaries developed between the Seventeenth and the early Eighteenth centuries to interpret Hinduism. The period considered follows the end of the Portuguese monopoly on the sea route to India and precedes the emergence of secular indology. From the early seventeenth century, Jesuit missionaries as Giacomo Fenicio, Roberto Nobili and Gonçalo Fernandes composed detailed descriptions of Indian “heathenism” that were circulated in manuscript form and plagiarized extensively. Elementary notions of Hinduism were found in printed versions of Jesuit letters and in works published by members of other religious orders. Using archival material, printed works and visual sources, I will analyse how theology, antiquarianism and classical learning were deployed in order to understand a religion that the missionaries wanted to replace with Catholicism. By basing myself at the Warburg Institute, London, I will be trained in the study of the classical tradition and early modern scholarship; moreover, I will benefit substantially from the Institute’s world-renowned tradition of using visual sources as evidence of anthropological representations. My project will test the hypothesis of a specifically Catholic early modern representation of Hinduism by examining the tensions between a common Catholic framework and differences in national backgrounds and religious orders, as well as investigating the circulation of indological knowledge in Europe between Catholics and Protestants. The goal is a book that will contribute to a comprehensive history of the relations between Europe and India. Europe needs to be aware of these complex processes, as a multipolar world takes shape and India becomes a major economic, political and cultural actor.
Rare and Common Genetic Variants analysis in ASDs and ADHD (GEVAD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-01-01
End date: 2012-12-31
Duration (months): 24.0
Total project cost (EUR): 153417.0
EU funding (EUR): 153417.0
Participants: 1
Project status: CLOSED

Autism (OMIM 209850) and attention deficit/hyperactivity disorder (ADHD) (OMIM 143465) are severe neurodevelopmental disorders with a complex etiology, caused by the interaction of multiple susceptibility genes, environmental and epigenetic factors. Autism and ADHD are the most common developmental disabilities after mental retardation. Different genetic approaches have been used so far to identify the genetic factors underlying complex disorders including linkage studies, association studies, search for cytogenetic abnormalities or Copy Number Variants (CNVs) analysis. The results obtained through these methodologies in recent years indicate that complex diseases such as Autism or ADHD are likely to be caused by a combination of common variants and multiple rare variants at different loci. However, these efforts have resulted in a limited number of significant and replicated findings, that explain only a small part of the genetic contribution to these disorders. The GEVAD proposal (Rare and Common Genetic Variants analysis in ASD and ADHD) aim to identify the genetic factors involved in the susceptibility to Autism and ADHD. The proposal will take advantage of modern high-throughput DNA technologies and expert collaborations to carry out three main studies: 1) Case/Control association studies of SNPs located in miRNA genes and in miRNA-binding motifs of selected candidate genes for Autism and ADHD 2) Replication of rare Copy Number Variants (NRXN1, CNTNAP2,SHANK3, IMMP2L-DOCK4) in autism and exploration of these structural variants as susceptibility factors for ADHD 3) Exome mutation analysis of autistic patients. To our knowledge, this will be the first exome analysis performed in a complex disease. The results emerging from GEVAD will provide new insights into the genetic basis of ASD and ADHD and may point to potential therapeutic targets for these common neuropsychiatric disorders.

Keywords: autism,adhd,association studies,copy number variants analysis,exome mutation analysis
In need for food intake control; should I get tempted more or less? (FOOD TEMPTATIONS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-09-01
End date: 2012-10-31
Duration (months): 26.0
Total project cost (EUR): 168035.2
EU funding (EUR): 168035.2
Participants: 1
Project status: CLOSED

The prevalence of obesity and overweight has increased dramatically over the last few decades, especially in Europe. In addition to genetic determinants, societal changes, worldwide nutrition trends, and market forces, like larger serving sizes, are often cited as driving the obesity epidemic. Together, these trends created an ‘obesogenic environment’ characterized by a multitude of unhealthy and easily accessible temptations which led to an enormous increase in the consumption of fattening snacks. Health organizations and consumers themselves introduce and apply strategies to reduce the temptation strength of unhealthy foods (e.g. stimulating low-fat products and rationing the purchase quantities) because they belief they can combat the obesity epidemic in this way. A number of academic findings supports this belief by showing that exposure to palatable foods activates a craving for food and stimulates eating behavior. However, some recent studies demonstrate that some of these activities can backfire because temptations may also activate counteractive self-control helping individuals stick to their goals. In sum, conflicting findings exist on the effect of food temptations on consumers’ ability to control their food intake, which urge for proper investigation in order to get a deeper insight in the effects and processes underlying them. We will start by looking at social psychological theories that can give insights in which factors determine the direction of the effect of food temptations on consumers’ self-control which will result in an adaptation of the psychological model into a consumer behavior oriented model. In a next step, the adapted model will be tested in a meta-analytic study. It is of high importance for public policy and marketers to know under which conditions food temptations (dis)enhance self-control. In this way, the findings can be used for the development of more efficient strategies to combat the obesity epidemic.

Keywords: marketing,experimental psychology,social psychology,food temptation,self-control ability,self-control strategy,food intake,overweight,temptation threat
Experimental Macroeconomics: Expectations and Monetary Policy Design (EXPMAC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-05-01
End date: 2012-04-30
Duration (months): 24.0
Total project cost (EUR): 161248.8
EU funding (EUR): 161248.8
Participants: 1
Project status: CLOSED

The objective of this proposal is to address three issues in the hart of the debate in modern macroeconomics, and in particular in monetary economics. All these issues will be analyzed with a new and innovative research methodology within this field: laboratory experiments. This field has a lot of potential to address some of questions regarding monetary policy design as we abstract from the influence of exogenous factors and thus it is quite straightforward to analyze properties of the standard macroeconomic model under different expectation formation processes. The first two issues are concerned with the design of monetary policy: first to establish the relationship between monetary policy and expectation formation mechanism and second to investigate what is the optimal level of transparency and central bank communication strategy to stabilize inflation and output. We search for the design of monetary policy that would perform best in a controlled environment when subject are asked to forecast inflation and output. In order that this can be achieved inflation expectations should be well anchored. It is expected that several designs proposed in the literature will not prevent the emergence of expectations driven cycles. A third issue that will be addressed in this proposal is to put the standard sticky-price New Keynesian Dynamic Stochastic General Equilibrium (DSGE) model to the test in the laboratory. Using subjects’ inputs and decisions in a simplified fictitious economy with households, firms, and policy makers, we will derive the main macroeconomics aggregates and compare their evolution and their reactions to monetary policy changes with the theoretical predictions from the DSGE models and actual observed stylized facts. The final objective of this project is the dissemination of results and organization of an academic conference on the proposed topic.

Keywords: experimental macroeconomics,expectations,monetary policy design,kew keynesian dsge models.
Power Gear Box (PGB) advanced planet bearings development (ABAG)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Germany
Call:  (SP1-JTI-CS-2009-01, 2009)
Start date: 2010-01-01
End date: 2013-12-31
Duration (months): 48.0
Total project cost (EUR): 598300.0
EU funding (EUR): 299150.0
Participants: 1
Project status: CLOSED

The ABAG (Advanced Bearings And Gears) project supports the SAGE2 project aims to demonstrate technologies for a Geared CROR (Counter-Rotating Open-Rotor) engine concept. The gearbox system requirements, transferring power from the low pressure turbine to the propellers, lead to the need of new, advanced technologies for critical components in particular bearings and their integration with the surrounding components (e.g. gears). The task and technical objectives are in particular: -Advanced planet bearing design including static and dynamic analysis considering the foreseen working conditions. - Definition of new technologies to meet the bearing life and reliability requirement under the expected operation conditions and technology development steps. - Demonstration through experimental test of bearing life and wear resistance (low contamination sensitivity) improvement of new technologies. - Demonstration through experimental tests for the applicability of the new technologies to gear materials and geometry of optimum bearing integration. The activity will be managed with a Phase &amp; Gate approach and will include detailed technical/program documentation, including planning, drawings, design report, risk analysis, test plan and test requirements, test results and test analysis reports.

Keywords: gears,gear box,planet bearing,bearing life,reliability,wear resistance
Molecular signatures: a systems biology tool to understand how leaf development is constrained by drought (MOLSIG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-08-01
End date: 2011-07-31
Duration (months): 12.0
Total project cost (EUR): 121644.8
EU funding (EUR): 121644.8
Participants: 1
Project status: CLOSED

The EU has acknowledged that urgent action is needed to put Europe in the forefront of systems biology research including rapid adaptation of training schemes and investment in cutting-edge research. The MolSig project will provide the Marie Curie (MC) fellow with systems biology training via hands-on research activities to develop a new systems biology tool to link changes in transcript and protein abundance to leaf development under drought. Europe is facing more frequent and intense periods of drought leading to serious reductions in crop yields and it is vital to have a comprehensive understanding of how gene regulatory networks control plant growth under drought. The objectives of the research are: (i) to identify leaf growth/drought molecular signatures (transcripts and protein phosphorylation events) that report on biological processes occurring during leaf development under drought; (ii) to quantitatively measure phenotypic responses of leaf development under drought; (iii) to test how transcript and phosphoprotein signatures change during leaf development under drought; (iv) to employ computational modelling methods to use the transcript/phosphoprotein signatures to examine relationships between biological processes and their influence on leaf development under drought. During this project, the MC fellow will receive training in computational biology, and high-throughput technologies including deep phenotyping, Q-PCR robotic pipetting systems and shotgun mass spectrometry identification of protein phosphorylation events. Training in complementary skills will include project management, grant writing, systems biology staff supervision, collaboration building and institutional organization. The program will contribute to the MC fellow’s career development by introducing systems biology approaches to his research programs, enhancing his capacity to build European-wide collaborations, and strengthening his abilities in management at the institutional level.

Keywords: plant systems biology,molecular signatures,arabidopsis,leaf development drought,high-throughput technologies,training
Social Learning Processes in Natural Resource Management: the Role of Learning, Negotiation and Social Capital for more Sustainable Natural Resource Management (SLINNRM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-06-01
End date: 2012-03-31
Duration (months): 22.0
Total project cost (EUR): 148061.4
EU funding (EUR): 148061.4
Participants: 1
Project status: CLOSED

The proposal suggest to undertake conceptual and empirical research about learning-based approaches to natural resource management and more precisely aims to use the construct of social learning, defined as a framework used to study collective decision making processes and the resulting change processes, in an empirical investigation of two cases of natural resource management. This proposal has five research objectives: investigate learning process with relation to different levels of aggregation; investigate the relationship between learning processes and social capital; develop a suitable research methodology; undertake an empirical study in a natural setting; and bring conceptual and empirical insights into a theory-building exercise. The reasons for carrying out further research on learning-based approaches relate to the need for resource management approaches that are adaptive and able to cope with uncertainty and complexity, and can accommodate different user groups. In addressing the above mentioned research objectives this project can contribute to refine the understanding of learning-based approaches and can produce knowledge, which can support practitioners and decision-makers in the development of methods/tools/processes best able to engage actors at various levels for collective decision-making, and sustainable change process. This knowledge and tools can benefit other domains as well, where human action is central, for instance sustainable consumption or climate change. .

Keywords: environmental policies (environmental protection),social psychology,involving society,learning studies,rural sociology,natural resources management
Combination Amine and Metal Cascade Catalysis (COMBICAT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-06-01
End date: 2012-05-31
Duration (months): 24.0
Total project cost (EUR): 180103.2
EU funding (EUR): 180103.2
Participants: 1
Project status: CLOSED

During this Fellowship we wish to develop new and synthetically powerful cyclisation cascades using combinations of amine organocatalysts and transition metal catalysts. Carefully chosen combinations of these catalysts should allow ketone functionality to be activated through conversion to a transient enamine intermediate that is then poised to attack the transition metal-activated alkyne or allene functionality. This concept can be extended to new annulation methodology when enone Michael acceptors are employed. In this case carbon acids tethered to alkyne or allene functionality can undergo an initial Michael addition under iminium ion (LUMO lowering) activation using amine organocatalysts and the generated enamine intermediate is then poised to attack the transition metal-activated alkyne or allene group. Furthermore, through use of effective single enantiomer organocatalysts it is possible to render this powerful carboannulation reaction asymmetric. As the majority of pharmaceutical compounds on the market are chiral and sold in single enantiomeric form, the provision of new, synthetically useful asymmetric reactions, reaction cascades and novel catalyst combinations will benefit the synthetic community in Europe by allowing drugs and drug intermediates to be constructed rapidly whilst minimizing waste. It is envisaged that the Fellowship will lead to a detailed understanding of the mechanistic processes and origins of stereocontrol in the developed reactions through employment of physical organic chemistry and computational chemistry techniques to the reactions where relevant. This understanding will further advance the state-of-the-art in field and thus benefit those working in both academia and industry alike. The work will therefore have widespread benefits for the European Community.

Keywords: organic chemistry,carbon chemistry,homogeneous catalysis,cascade catalysis,asymmetric catalysis
Hydrogel-Phage Composite Materials and Droplet Microfluidics (PHAGE-BEADS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-05-01
End date: 2012-04-30
Duration (months): 24.0
Total project cost (EUR): 180603.2
EU funding (EUR): 180603.2
Participants: 1
Project status: CLOSED

Virus particles are increasingly used as building blocks for composite materials. Surface modification of these biological nanoparticles can be accomplished by genetic engineering and offers the possibility to combine directed evolution of molecular function with the assembly of more complex materials and devices. Virus display systems, especially phage display, have been extensively used for evolving peptides and proteins capable of specific binding to a diverse range of biomacromolecules and inorganic materials. Recently life science approaches emerged using virus particles as substitute antibodies in diagnostic tools. To harvest the full potential in connecting virus display technology with materials, smart fluid handling approaches must be applied allowing to process high numbers of samples. This project is about combining droplet microfluidics, a technology dealing with monodisperse water in oil emulsion droplets, with phage display. The emulsion droplets represent isolated vessels with volumes in the pico- to nanoliter range and can be split, merged, incubated and sorted at high frequency. In addition, hydrogel matrixes will be applied. They serve as scaffold for phage immobilization and allow to transfer the sample from emulsion to an aqueous phase while retaining compartimentalization. The resulting gel beads will be designed as such that proteins can diffuse freely while the phages are immobilized in the matrix. The concept will be applied for directed evolution of enzymes and the development of novel diagnostic tools.

Keywords: biomaterial engineering,genetic selection,enzimology,microengineering
Comprehensive and systematic study of the acetylation function of acetyltransferases in human cells (ACETO-SAGATAC-HUMAN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2011-01-01
End date: 2012-12-31
Duration (months): 24.0
Total project cost (EUR): 163145.6
EU funding (EUR): 163145.6
Participants: 1
Project status: CLOSED

Histone acetyltransferases (HATs) play a critical role in regulating gene expression of many cellular functions. Interestingly, the vision of histones being unique substrates for different HATs has recently changed, since HATs can also regulate essential functions such as protein turnover or cell cycle progression, via acetylation of non-histone proteins. HATs and their acetylation activity must have multiple physiological roles, which are still poorly understood. This is especially the case of GCN5 and PCAF, which are homologous HATs, but have different roles in vivo. Because a fine balance between acetylation and deacetylation regulates many cellular functions and the smallest change in this balance can lead to cancerogenesis, it is extremely important to understand the global acetylation function of HATs. In order to get more insights into functional role of HATs and acetylation in human cells in vivo, we propose to identify substrates of the human HATs, GCN5 and PCAF using systematic proteomic analysis. The targets of these HATs, either as recombinant enzymes or within their associated protein complexes, SAGA (Spt-Ada-Gcn5 acetylase) and ATAC (ADA Two-A containing Complexe), will be screened performing acetyltransferase assay on a human protein array containing more than 9000 proteins. Changes in acetylome will be also compared in between wild-type and cells lacking GCN5/PCAF using cutting-edge proteomic methodology such as Multidimensional Protein Identification Technology (MudPIT). Once the specific non-histone targets of these HAT complexes will be defined by the combination of these methods, we will carry out physiological studies to understand the in vivo regulatory role of these acetylation patterns determined by the SAGA and/or ATAC complexes. The success of this project will rely on the synergic interaction between the fellow’s unique expertise in proteomic studies and the knowledge of the host laboratory leader in the field of transcription regulation.

Keywords: histone acetyltransferases function human cancer proteomics