Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mapping Argument Structure in Early Irish and Welsh (MAIRWEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The proposed project involves a critical examination of the concept of subject and subject properties in Old Irish and Old and Middle Welsh. The project has three objectives: 1) to determine subject properties in Old Irish and Old and Middle Welsh, 2) to investigate the applicability of subject tests proposed in the literature for the early Indo-European languages, modern Indo-European languages, and, specifically, Modern Irish and Modern Welsh to Old Irish and Old and Middle Welsh, and 3) to develop subject tests specifically for Old Irish and Old and Middle Welsh. The approach is rooted in the methodology and theoretical framework of cognitive linguistics and construction grammar, as well as in comparative and philological methodologies. Applying the tools of cognitive linguistics and construction grammar to Early Irish and Welsh, while remaining faithful to the comparative and philological framework, allows for the generation of the relevant knowledge of the grammar of Early Irish and Welsh that is needed to decipher and model subject behaviour in these languages. Working at Aberystwyth University will enable me to improve and deepen my skills and competencies in Early Welsh, Modern Welsh and Modern Irish. Expanding my current work, which has been focussed Medieval Irish, both laterally into medieval Welsh and vertically into the modern languages will significantly improve and increase my career opportunities. By the end of this project, I will have at least four articles and a monograph submitted for publication, demonstrating my capacity to carry out high-quality, independent research in Early Welsh as well as in Early Irish and theoretical linguistics, in addition to being able to speak and teach both Modern Irish and Modern Welsh at an advanced level, providing me with a strong chance to obtain a permanent academic position in Celtic linguistics.

Keywords: celtic,old irish,middle welsh,subjecthood,subject properties,argument structure
LANTHANIDE ION DOPING OF TERNARY QUANTUM DOTS (LANTERNS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

This project aims to address the current limitations of existing in vivo optical imaging nanoprobes (ONPs). Specifically, the present study targets a tangible breakthrough that will increase both the optical contrast and sub-tissue penetration depth of optical imaging, compared to that obtainable with state-of-the art contrast agents. In particular, the ability to optically overcome the limitations imposed by autofluorescence (light endogenously generated by the specimen upon irradiation) constitutes a very demanding requirement for the real-life application of ONPs. In LANTERNS my proposal is to accomplish the above-mentioned goals through an elegant marriage between lanthanide (Ln) ions and chalcogenide ternary quantum dots (QDs), the latter acting as a host for the ions. These smartly-designed ONPs (Ln-QDs) will have a superior capability for minimally-invasive deep-tissue imaging, owing to an unprecedented brightness and fully near-infrared (NIR) operational capabilities. These features will endow the so-designed Ln-QDs with outstanding optical contrast and sub-tissue penetration depth. In perspective, the development of this system will deliver an all-optical diagnostic practice that will reduce patient risk, in terms of possible harm, and lessen the amount of radiation required to localize malignancies. These goals will be achieved concurrently with a considerable reduction of the imaging costs via the use of low-cost excitation sources and signal detection setups, also shortening the imaging times. The project is also expected to lead to the assessment of a widely applicable method to produce a virtually infinite number of Ln-QDs, whose optical properties could be finely tuned throughout the entire optical radiation spectrum. Beyond the main biomedical aim of this project, the expected progress will constitute a significant leap within the luminescent materials science field, with an appeal to a broad scientific community.

Keywords: quantum dot,sulfide,lanthanide ion,nanoprobe,imaging
RISEWISE – JAM Sharing and illustrating experiences of Women with Disability in a EU research project (RISEWISE JAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy
Call: MSCA Special Needs Allowance (H2020-IBA-MSCA-SNLS-2019, 2019)
Start date: 2019-06-01
End date: 2021-02-28
Duration (months): 21.0
Total project cost (EUR): 15000.0
EU funding (EUR): 15000.0
Participants: 1
Project status: CLOSED

The Marie Skłodowska-Curie actions pay particular attention to physical accessibility and inclusion and foresee financial support for the additional costs entailed by recruited or seconded researchers/staff members with disabilities. This grant will cover the additional costs that the staff member with disabilities faces due to the increased mobility costs.

Keywords: disability,inclusion,difference,special needs,gender,rise,accessibility
Development of small molecule OGG1 Inhibitor and proof of concept in bleomycin-induced disease model of Inflammation and pulmonary Fibrosis (DOIIF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2020-11-01
End date: 2022-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Fibrosis in response to tissue damage or persistent inflammation is a pathological hallmark of many chronic degenerative diseases where Idiopathic Pulmonary Fibrosis (IPF) is one of the most severe diseases. IPF is a progressive condition with unknown etiology and a median survival of three years from diagnosis. Current medical treatment is limited to slowing down the disease and thus there is still a high unmet medical need. OGG1 enzyme has a major role in DNA repair in conditions of oxidative stress and also in regulation of gene transcription involved in immune responses. In our ERC grant we developed a first-in class OGG1 inhibitor that protects from exaggerated immune response induced by the proinflammatory mediator TNFα. We have shown with this compound in several airway inflammation models, that inhibition of OGG1 results in a significant down regulation of mediators associated with inflammation and fibrosis, reduced infiltration of immune cells in lungs and increased alveolar integrity compared with control. We have developed a large number of compounds and in this proposal we aim to demonstrate proof of concept (PoC) for the most promising compound in an established model of pulmonary fibrotic diseases in order to select a candidate drug (CD). Our plan is to establish collaboration with industrial partners for further development in order take one compound through preclinical development and clinical phase 1/2a for further commercialization. Treatment with a potent OGG1 inhibitor has the potential to attenuate or resolve the progress of the disease, alone or in combination with existing therapies and increase survival of IPF patients and reduce healthcare costs.

Keywords: ogg1 inhibitor,small molecules,inflammation,fibrosis,drug development
Combining in vivo spectral biphoton imaging and multiparametric cytometry to characterize the dynamics of the innate immune response in a multiple sclerosis mouse model (InnateMSDyn)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2018-06-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Multiple sclerosis (MS) disease is dependent on an intricate interplay between the adaptive and innate immune systems. Nevertheless, none of the Food and Drug Administration-approved drugs target innate immune cells, because of their unclear roles in the disease process. However, innate immune cells implication in the MS disease is no longer put in doubt. The mobilization, differentiation and spatial-temporal distribution of brain resident and recruited peripheral innate immune cells, in relation with clinical scores, will be analyzed, as an alternative source of disease biomarkers and therapeutic targets. The project combines recent advances in (a) generation of multicolor transgenic reporter mice with subpopulations of cells expressing distinct fluorophores, (b) spectral bi-photon imaging to visualize the cells of interest directly in the spinal cord in living animals, at a subcellular resolution in real time, and (c) multiparametric flow cytometry to characterize over time inflammatory cell types in the spinal cord tissue after disease induction. The activated cells converging to the neuronal lesions, as well as the delay and the effect on the neurons, will be characterized. VEGF will also be tested as potential therapeutic drug, based on the known VEGF effects on neurons and immune cells. This data will provide new insights on MS disease setting up and implicated cells, correlated with clinical scores, neuronal damages and disease progression.

Keywords: multiple sclerosis,mouse spinal cord,intravital two photon imaging,multiparamatric flow cytometry
Collective Innovation for Public Transport in European Cities (CIPTEC)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Belgium,Belgium,Belgium,Greece,France,Netherlands,Netherlands,United Kingdom
Call: Tackling urban road congestion (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 36.0
Total project cost (EUR): 3498350.0
EU funding (EUR): 3498350.0
Participants: 12
Project status: CLOSED

CIPTEC introduces an integrated approach which draws on the best ideas deriving from marketing (i.e. customer orientation, marketing research, consumer intelligence), consumer behaviour (i.e. advanced motivational research, behavioural experimentation), innovation (i.e. crowd sourcing, collective intelligence, co-creation and co-design of new ideas, fusion of business concepts with social innovation), evaluation (i.e. socioeconomic, technological and ethical) and co-exploitation within a wider than usual stakeholder platform attacking the challenges that hinder the public transport “environment” transition and re-orientation towards increasing PT market shares, thus substantially contributing to urban road congestion reduction in a sustainable manner. In the frame of CIPTEC, we study the demand side and how its needs are affected by the continuous storm of change but we take a close look to the supply in an attempt to demystify the needs and understand the distinct challenges PT providers face in tackling the same changes.. We dig out and map promising existing innovation from PT and adjacent fields but we also put forth a collective intelligence subprogram to crowd-source and co-produce novel approaches to tackle underserved needs. We survey public transport users to appreciate the finer differences in preferences for the promising innovations but we dig deeper looking for motivation triggers able to achieve natural behaviour change – not only in the lab but in real life. We provide a translation-in-a-box of our results but we don’t wait for stakeholders to use them; we work with them to motivate and apply these insights into concrete street-action. We invite the broader community to cooperate along the value chain but we bring along an unexpected ally – social entrepreneurs - to build and apply disruptive models of sustainable and replicable value. Our team is set to provide evidence and innovative tools for achieving growth in European public transport.

Keywords: innovation,collective intelligence,toolbox,crowdsourcing,co creation workshops,consumer experimentation,cooperative synergies,marketing research,user needs,services integration,incentives
Characterization of 7q11.23 reciprocal aneusomy syndromes: from patients to functional pathways (and back) (7DUP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Technological advances have allowed the identification of multiple rare rearrangements caused by structural and copy number variants (CNVs). The 7q11.23 microduplication syndrome (7dup) and Williams-Beuren (WBS) syndromes are originated by genomic reciprocal rearrangements that result in opposite phenotypic features in the area of communication and sociability. Although WBS has been extensively studied, there is lack of exhaustive studies of 7dup at the clinical and molecular levels. In this project, we aim to compile and characterize a large group of 7dup patients. Moreover, we will actively collaborate with a recently created 7dup support group. Little is known about the functional mechanisms disrupted by these aneusomy syndromes and the specific alterations caused during brain development. Limitations in the available animal models, lack of quantitative data and limited computational capabilities have precluded the identification of relevant molecular pathways involved in these disorders. This proposal aims to overcome these limitations by applying an integrative multidisciplinary approach involving experimental and computational methods. To generate human neuronal in vitro models, somatic cells from a defined subset of individuals with 7dup and WBS will be reprogrammed to obtain induced pluripotent stem cells and differentiated to neurons. To define neuron-specific alteration patterns in gene expression caused by these CNVs we will perform transcriptome analyses at multiple differentiation stages. Finally, the expression data will be integrated with protein interaction and other systematic gene annotations datasets to perform omic analyses to identify dysregulated pathways. Our results will help to better characterize at clinical and molecular level the unexplored 7dup disorder; to improve understanding of the functional basis involved in this reciprocal aneusomy syndromes; and to generate a disease model to test and determine appropriate therapeutic targets.

Keywords: 7q11 23 microduplication syndrome,williams beuren syndrome,copy number variant,human induced pluripotent stem cell,hipsc,rna seq,omics integrative analyses
iFERMENTER - CONVERSION OF FORESTRY SUGAR RESIDUAL STREAMS TO ANTIMICROBIAL PROTEINS BY INTELLIGENT FERMENTATION (iFermenter)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Austria,Germany,Germany,Spain,Germany,Norway,Belgium,Belgium,Switzerland,Norway,Denmark
Call: Proteins and other bioactive ingredients from side streams and residues (H2020-BBI-JTI-2017, 2017)
Start date: 2018-05-01
End date: 2022-07-31
Duration (months): 51.0
Total project cost (EUR): 5320895.0
EU funding (EUR): 3997825.0
Participants: 12
Project status: CLOSED

Plant dry matter, so-called lignocellulosic biomass, is the largest renewable biomass feedstock on Earth. Europe has over 14 mill tons of sugar residuals from biorefineries, which could be converted to profitable products and contribute to a sustainable bioeconomy. Unfortunately, existing biorefineries struggle with technical issues and low profitability due to the lack of adequate fermentation processes. Therefore, these sugars are either incinerated to generate energy or at best converted to ethanol (€0.6 /kg) but not to higher value chemicals. Current concepts that aim to establish fermentation processes to convert residual sugar streams to high value products face challenges including inefficient sugar utilization by microorganisms and inhibitors in the residual streams, leading to low productivity and yields. Our project aims to recover high value compounds from sugar residuals, and to turn fermentation processes converting these residual to antimicrobials cost effective. We will recover the high value sugar galactose (€40-200 /kg) from residual streams as part of their treatment process. By genome editing technique, we will design cell factories that consume the remaining residuals and produce nisin (€50-150 /kg), an industrially important commercial food/feed preservative. Additionally, we will develop an affordable, online feedback add-on system that will allow to intelligently change residual mixture during fermentation of these cell factories to optimize production online during the process. In a 150 L industrial bioreactor, we will demonstrate that our add-on invention iFermenter - increases the yields of nisin by over 2 fold - increases the pediocin production by over 50% compared to what is possible today, - and reduce at least 20% in CO2 footprint with this process compared to existing solutions. Thus, iFermenter will render production of high value products with residual sugar stream highly efficient and cost-effective contributing to circular economy.

Keywords: synthetic biology,biorefinery residual stream,sugar conversion,sugar recovery,antimicrobial proteins
From Biopigments to BIOelectronics: MOdelling Semiconducting EumelAnin-based InterfaCes (BIOMOSAIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The overall aim of this proposal is to build a comprehensive model of ionic and electronic transport in organic bioelectronics considering a prototypical material, eumelanin, as a proof of concept. Bioelectronic devices are used in nanomedicine for implantable, wearable and sensing applications. Eumelanin is a natural biocompatible semiconductor with great potential in bioelectronics due to its joint electronic and ionic conductivity. However, a full picture of its interactions with water and electrolytes and how these influence its semiconducting properties is still missing, thus holding back a systematic improvement of eumelanin-based devices. This project will provide the first unified picture of eumelanin’s mixed conduction by simulating electronic and ionic charge transport at device-relevant scales and combining them in a numerical model. This will be achieved through four innovative steps towards eumelanin characterisation: i) reactive molecular dynamics (MD) simulations will capture the details of water-eumelanin interactions; ii) a classical MD approach will describe ionic conduction in hydrated eumelanin; iii) electronic structure methods will relate eumelanin’s morphology to its electronic conductivity. iv) The previous insight will be combined in a model describing mixed conduction in eumelanin-based devices, allowing the formulation of general design rules for the development of new bioelectronic materials. Planned collaborations with leading groups in eumelanin bioelectronics will provide experimental data to build and validate the model, resulting in high-impact publications and contributing to European competitiveness in bioelectronics. The complementary nature of the researcher and host’s research profiles is instrumental in fulfilling the complex, interdisciplinary aims of the project. The Fellowship will allow the researcher to expand her knowledge beyond her existing skills, enabling her transition towards an independent academic career.

Keywords: bioelectronics,biomaterials,eumelanin,soft matter,organic semiconductors,organic electrochemical transistors,charge transport,ion transport,molecular dynamics simulations,kinetic monte carlo
Growth-Special Needs Lump Sum (GROWTH-SNLS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Action type: Marie Skłodowska-Curie actions
Countries involved: France
Call: MSCA Special Needs Allowance (H2020-IBA-MSCA-SNLS-2019, 2019)
Start date: 2019-11-08
End date: 2023-05-07
Duration (months): 42.0
Total project cost (EUR): 10100.0
EU funding (EUR): 7070.0
Participants: 1
Project status: CLOSED

Request of financial support to cover the additional costs that researchers/staff members with disabilities face due to the increased costs of their mobility and/or to ensure necessary assistance by third persons or for adapting their work environment.

Keywords: dry lab,wet lab,ergonomic equipment