Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Coordination of cell growth and cell division (GROWTH AND DIVISION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-10-01
End date: 2013-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The dynamic properties of the cytoskeleton facilitate cell growth and cell division. The pattern and amount of cell growth, combined with the timing of cell division, generates the spectrum of cell sizes and shapes found in nature. Despite the fundamental importance of these processes, remarkably little is known about how cell growth and cell division are coordinated. In budding yeast, a core component of the cell cycle machinery, cyclin dependent kinase 1 (Cdk1), triggers polarization of the actin cytoskeleton and growth of a new cell early in the cell cycle. This places Cdk1 activity at the hub between the control of polarized cell growth and cell division. My work has demonstrated that signaling from Cdk1 activates highly conserved Rho family GTPases, including Cdc42, which both establish and maintain an axis of polarity along which cell division occurs. Cdk1 triggers the activation of Cdc42 via phosphorylation of a novel multi-protein complex that I have identified by mass spectrometry, comprising of multiple Cdc42 regulators. Exploring the mechanisms by which Cdc42 is activated by Cdk1 activity, and the targets that lie downstream of Cdc42, will therefore improve our understanding of how cell growth and cell division are coordinated, a key unresolved issue in cell biology.

Keywords: life science,biology,cell biology,cell cycle,cell growth,cell polarity,rho gtpases,cyclin dependent kinase
Psychosocial Factors and Cardiovascular Disease in Spain (PSYCHO CARDIO SPAIN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-11-01
End date: 2014-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

The study of the possible associations of psychosocial factors as job strain, depression, social support and stress, with the development, treatment and prognosis of cardiovascular disease (CVD) is a promising research field. Job strain and depression are highly prevalent conditions, and CVD remains to be the first cause of death in most countries around the world. Nevertheless, only a few cardiovascular studies have been able to study this topic in a low cardiovascular risk country as Spain. We will be able to study the role of psychosocial factors with CVD outcomes within two large cardiovascular cohort studies of workers. The different populations of these studies in terms of geographical location, sex distribution, age range, and different occupations, offer a great opportunity for the study of well defined psychosocial factors and their role in CVD etiology, and progression. We will use well established and already validated questionnaires to measure job strain, depression, social support and stress. The knowledge produced on the possible associations between common psychosocial factors as job strain and depression with the development and progression of CVD will offer excellent opportunities for preventive cardiovascular interventions not only in Spain but in other countries of the European Union with similar cardiovascular risk.

Keywords: health sciences,epidemiology,cardiovascular disease,obesity,overweight
Combination of Shear Stress and Molecular Imaging of Inflammation to Predict High-Risk Atherosclerotic Plaque (SMILE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-04-12
End date: 2014-04-11
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Although the detailed pathophysiologic triggers responsible for the individual natural history trajectory of each atherosclerotic plaque are unknown, the local, dynamic interplay between low endothelial shear stress (ESS) and vascular inflammation is likely to be critical. The purpose of the proposed project is to combine ESS with inflammation in a plaque risk classification scheme aiming to predict high-risk plaque at early stages of its development before its rupture. Enhancing our understanding of the magnitude of local hemodynamic stimulus with respect to inflammation (i.e. ESS), as well as the extent of local inflammation would allow us to detect early, minimally stenotic, atherosclerotic lesions and stratify the risk of them evolving into high-risk plaques. The latter classification is of utmost clinical importance as it can provide a rationale for innovative diagnostic and/or therapeutic strategies for the management of coronary patients, as well as the prevention of acute coronary syndrome. Identification of a high-risk plaque at its early stages of development would potentially justify highly selective, prophylactic local interventions, such as implantation of stents or targeted nanoparticle-based delivery of anti-inflammatory drugs, supplemented by an intensive systemic pharmacologic approach to limit the severity of inflammation, stabilize the plaque, and thereby avert a future acute coronary event. The clinical and economic implications of identifying and treating high-risk individual coronary lesions before an adverse cardiac event can occur are anticipated to be enormous.

Keywords: health sciences,cardiology,atherosclerosis
Resveratrol-induced molecular markers in cancer and progenitor cells proliferation (RESVERATROL ROLES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2011-01-01
End date: 2014-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Many genes that have been shown to cause cancer were originally identified because of their role in embryonic development and in the postnatal control of cell growth and differentiation. The similarities between cancer and development are evident on many levels. Microscopically, cancerous tissues frequently appear as undifferentiated masses, with some tumor types exhibiting embryonic tissue organization. The increased mobility of cancer cells, leading to local invasion or metastasis, is reminiscent of the migratory behavior of cells during development. We aim to have deeper tumor biology knowledge through gene regulatory network (GRN) models. We consider the characterization of GRNs of tissue specific progenitor/stem cells as a paramount to our understanding of cancerogenesis in colon, lung, and pharynx (CLP) tumor cells. This research proposal underlies the hypothesis that some cancer cells are closely related to progenitor cell of respective tissue, therefore the tumor drug selection should resemble proper stem/progenitor cell differentiation signaling pathway perturbation. We believe that such tumor-customized drug treatment will be more successful, it will shed light on the comprehension of drug effect overall. Moreover it will highlight new aspects of developmental and cancer biology mechanisms. We will use spheroid in vitro model and moreover we will adopt mouse model to validate in vitro data. The predicted outcome of this research is the identification of novel gene regulatory interactions that will be investigated for their roles in carcinogenetic tissues.

Keywords: health sciences,resveratrol,progenitor cell,cancer,spheroid
Self-Assembly of DNA-Functionalized Nanoparticles: a viable approach towards Supramolecular Crystals (SUPRACRYST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-11-01
End date: 2012-10-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Research towards 2D and 3D supramolecular crystal engineering is expected to play a key role in the development of controlled bottom-up fabrication of nanostructured devices. The ability to predict the self-assembly at different length scales, ultimately allowing to attain a full control over the interplay of kinetics and thermodynamics ruling the hierarchical self-assembly in inorganic and biological systems, is a fundamental prerequisite to the progress of the field. SUPRACRYST aims at contributing to the advance of such a central technological field in Europe, and in particular it will focus on the development of new DNA- and nanoparticle-based devices. The final goal will be the controlled engineering of 2D and 3D supramolecular crystals made of inorganic nanoparticles linked through the recognition of DNA single strands. The possibility of interfacing DNA with gold and magnetic nanoparticles, controlling both the geometry and the valence, will be explored. Structural DNA nanotechnology has opened up perspectives for the directed self-assembly of nanoparticles into patterned nanostructures that can lead to promising applications, such as photonic antennas and controlled plasmonic interactions. In this framework, the high-fidelity of DNA pairing code is exploited to program the assembly schemes, and single-stranded DNA (ss-DNA) will be used as couplings arms to steer the assembly of nano-units into functional 2D or 3D assemblies. The formation of ordered and disordered self-assembled condensed phases and their dependence on geometry and valence will be investigated. Controlling the length and flexibility of the binding DNA arms, as well as the architecture of the bonding pattern via the use of spacers and linkers, we aim to manipulate the obtained crystal structures and to tune the characteristic lattice spacing toward arrays of low nanoparticle density.

Keywords: surface chemistry,nanotechnologies,surface functionalization,supramolecular chemistry,self-assembly,nanoparticles,plasmon
Thermal-hydraulics of Innovative Nuclear Systems (THINS)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Research infrastructure
Destination: Reactor Systems
Action type: Collaborative project
Countries involved: Germany,France,Belgium,Italy,Netherlands,Switzerland,Germany,Sweden,Netherlands,Italy,Slovenia,United Kingdom,France,Germany,Italy,Belgium,Germany,Finland,United Kingdom,United States
Call:  (FP7-Fission-2009, 2009)
Start date: 2010-02-01
End date: 2015-01-31
Duration (months): 60.0
Total project cost (EUR): 10592854.8
EU funding (EUR): 5941810.8
Participants: 24
Project status: CLOSED

For the long-term development of nuclear power, innovative nuclear systems such as Gen-IV reactors and transmutation systems need to be developed for meeting future energy challenges. Thermal-hydraulics is recognized as a key scientific subject in the development of innovative reactor systems. This project is devoted to important crosscutting thermal-hydraulic issues encountered in various innovative nuclear systems, such as advanced reactor core thermal-hydraulics, single phase mixed convection and turbulence, specific multiphase flow, and code coupling and qualification. The main objectives of the project are: • Generation of a data base for the development and validation of new models and codes describing the selected crosscutting thermal-hydraulic phenomena. This data base contains both experimental data and data from direct numerical simulations (DNS). • Development of new physical models and modeling approaches for more accurate description of the crosscutting thermal-hydraulic phenomena such as heat transfer and flow mixing, turbulent flow modeling for a wide range of Prandtl numbers, and modeling of flows under strong influence of buoyancy. • Improvement of the numerical engineering tools and establishment of a numerical platform for the design analysis of the innovative nuclear systems. This platform contains numerical codes of various classes of spatial scales, i.e. system analysis, sub-channel analysis and CFD codes, their coupling and the guidelines for their applications. The project will achieve optimum usage of available European resources in experimental facilities, numerical tools and expertise. It will establish a new common platform of research results and research infrastructure. The main outcomes of the project will be a synergized infrastructure for thermal-hydraulic research of innovative nuclear systems in Europe.

Keywords: thermal-hydraulics,crosscutting issues,innovative nuclear systems,numerical tools
The early state and its chora. Towns, villages and landscape at Ebla in Syria during the 3rd Millennium BC. Royal archives, visual and material culture, remote sensing and artificial neural networks (EBLA CHORA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: The study of the human past
Countries involved: Italy
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-04-01
End date: 2014-03-31
Duration (months): 48.0
Total project cost (EUR): 1105240.0
EU funding (EUR): 1105240.0
Participants: 2
Project status: CLOSED

The case of Ebla in northern Syria is certainly the most favourable one for enhancing our understanding of mechanisms of functioning of the early state. The discovery in 1975 of royal archives consisting of 17.000 cuneiform tablets dating to c. 2300 BC has supplied the scientific community with an invaluable mass of documents dealing with all aspects of state organization. These tablets inform us about the political, diplomatic and military affairs of the Eblaite state, as well as on the economic and social fabric of this early state formation. Further, considerable progresses during the past decade have been made at Ebla in seriating material culture assemblages, in interpreting the rich evidence for ancient visual communication and in exposing the urban structure. We now foresee a unique opportunity to test theories and models about the rise and structure of the early state by expanding the level of analysis to the landscape around Ebla: archaeological surface surveys, remote sensing, geomorphological studies will be evaluated together with the results of archaeological and geophysic investigations on village sites. Our research group has already considerable experience in developing calculation programs that employ along with traditional statistic and quantitative methods within a web GIS environment, including all the cuneiform tablets models of modern dynamic mathematics: the massive amount of data obtained from excavations, surveys, epigraphic studies, archeometric and archeobiological analyses will be combined and analyzed by means of mathematical, economical and computer science concepts and models, in order to build a multi-tier explanatory pattern which can be applied also to other early foci of urbanization in the Near East and elsewhere. We thus hope to gain a much richer historical framework and a sophisticated predictive model of general validity: until now no studies have ever focused on explanations of these phenomena on such an integrated scale

Keywords: archaeology,early state,near east
RISK MANAGEMENT AFTER THE CRISIS (RMAC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Individuals, institutions and markets
Countries involved: Switzerland,France
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-03-01
End date: 2016-02-29
Duration (months): 72.0
Total project cost (EUR): 1440000.0
EU funding (EUR): 1440000.0
Participants: 2
Project status: CLOSED

The current financial crisis testifies that the sophisticated risk management models used by large financial institutions are inadequate. The main objective of this research project is to analyze the sources of this failure and to develop sound conceptual principles for founding new risk management methods for financial institutions. In spite of the wide use of sophisticated risk management models by the majority of large firms, the conceptual foundations for them are weak. Most of them rely on the assumption that financial markets always function well. The few theoretical models that incorporate endogenous financial frictions use contract theoretic tools but they are static or two period models. Such models cannot generate really testable implications, or provide quantitatively reasonable policy recommendations. Another strand of the theoretical literature has developed diffusion models for modelling the financial behaviour of corporations in continuous time. However this literature is mathematically oriented and makes very strong assumptions, without clear justifications. Our objective is to combine these two approaches and construct testable dynamic models with endogenous financial frictions. These models are to be simple enough that they can provide reasonable policy recommendations, with a particular attention to banks and insurance companies. By adapting the general model of corporate risk management in a dynamic set-up to the specificities of financial intermediaries, we will develop a model of risk management for the financial sector. Implications will be derived for prudential regulation of financial intermediaries and the organisation of supervision, with a particular attention to the prevention and management of future financial crises.

Keywords: risk management,financial contracting
The legal status of religious minorities in the Euro-mediterranean world (5th-16th centuries) (RELMIN)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: The study of the human past
Countries involved: France
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-03-01
End date: 2015-06-30
Duration (months): 64.0
Total project cost (EUR): 2305000.0
EU funding (EUR): 2305000.0
Participants: 1
Project status: CLOSED

European religious diversity has its roots in the practice of medieval societies. Medieval European polities, Christian and Muslim, granted protected and inferior status to selected religious minorities. RELMIN will collect, publish and study legal texts defining the status of religious minorities in pre-modern Europe. The corpus of texts includes Roman law (in particular in the legal codes of Theodosius and Justinian), canon law (acta of Church councils, the Decretum attributed to Gratian, the Decretales), national or royal law (from barbarian law codes of the early Middle Ages to national compilations such as the Siete Partidas of Alfonso X of Castile in the thirteenth century), urban law (particularly the fueros in the Iberian peninsula and hisba manuals in Andalusia), rabbinical responsa, and fatwa collections. The database will contain texts in their original languages and translations into English, French and Spanish, as well as an annotated bibliography on the subject. This will become a major reference tool for research in the history of minority law and of interreligious relations. The project will also hold workshops and a major international conference on Religious diversity in pre-modern Europe. A series of comparative thematic studies on specific aspects of interreligious relations will allow us to compare responses to similar issues in diverse societies, from seventh-century Córdoba to fifteenth-century Krakow. The goal is to encourage collaborative interdisciplinary work by scholars from different countries with varying linguistic skills, to encourage new innovative research that cuts across traditional divides. The project will publish three major works in the field: the proceedings of the international conference, a sourcebook of selected legal texts (with translations, commentaries and annotated bibliography), and a monograph on the legal status of minorities in pre-modern Europe.

Keywords: minorities,religion,persecution,tolerance,convivencia
Cognition and Decision-Making: Laws, Norms and Contracts (COGNITION)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Individuals, institutions and markets
Countries involved: France
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-04-01
End date: 2016-03-31
Duration (months): 72.0
Total project cost (EUR): 1910400.0
EU funding (EUR): 1910400.0
Participants: 1
Project status: CLOSED

The application's unifying theme is cognition. Any decision reflects the information that comes to the decision-maker's awareness at the moment of making the decision. In turn, this information is the stochastic outcome of a sequence of more or less conscious choices and of awareness manipulation by third parties. The three parts of this application all are concerned with two factors of limited awareness (cognitive costs and motivated beliefs) and with the application of imperfect cognition to economics. The various projects can be subsumed into three themes, each with different subprojects: 1. Self-serving beliefs, laws, norms and taboos (expressive function of the law, taboos, dignity and contracts). 2. Cognition, markets, and contracts (mechanism design under costly cognition, directing attention in markets and politics). 3. Cognition and individual decision-making (foundations of some non-standard preferences). The methodology for this research will be that of formal economic modeling and welfare analysis, enriched with important insights from psychology and sociology. It will also include experimental (laboratory) investigations. The output will first take the form of a series of articles in economics journals, as well as, for the research described in Part 1, a book to disseminate the research to broader, multidisciplinary and non-specialized audiences.

Keywords: self-beliefs,bounded rationality,psychology and economics,contracts