Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
BIO-inspired NAcre-like materials FOR the next generation of conservation treatments in stone ART works (BIONA4ART)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2022-06-30
Duration (months): 36.0
Total project cost (EUR): 245732.16
EU funding (EUR): 245732.16
Participants: 2
Project status: CLOSED

The degradation of our rich stone cultural heritage (CH) represents an irreversible loss; an issue that has become urgent due to the increase of natural decay caused by climate change and the impact of atmospheric pollution and/or the current use of inappropriate treatments against stone weathering. The main challenge of BIONA4ART project will be to address this issue within an innovative framework in the conservation science: i) the development of a new generation of bioinspired nacre-like composites with self- healing and antimicrobial properties; and ii) its validation as stone conservation treatments with the aid of advanced characterization techniques. Thereby this research is marked by an interdisciplinary approach involving material science, biomaterials, physics, chemistry, petrophysics and CH conservation. In order to develop the proposed research the applicant will acquire new research skills by partnering her with the three specialized institutions involved: the Spanish National Research Council (CSIC) (supervisor Prof. R. Fort, world-renowned expert in the stone CH conservation), the Johns Hopkins University (JHU) (supervisor: Prof. H. Fairbrother, expert in nanocomposites, environmental implications and applications of nanomaterials), and the Max Planck Institute for Polymer Research (MPI-P), (supervisor Dr. S. Weber, internationally recognized expert in the use and development of SFM methods to study the underlying physics of nanoscale systems). The new knowledge and transferable skills gained during the project coupled with the opening of an innovative and exciting research line in the stone-CH field, will be an ideal springboard for the applicant´s subsequent career, which is to become a fully independent academic researcher in a top european university.

Keywords: products and processes engineering product design,process design and control,construction methods,civil engineering,energy processes,material engineering
Sustainable energy system for achieving novel carbon neutral energy communities (SUSTENANCE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: India,Poland,Poland,Poland,Netherlands,Denmark,Denmark,Denmark
Call: Integrated local energy systems (Energy islands): International cooperation with India (H2020-LC-SC3-2020-NZE-RES-CC, 2020)
Start date: 2021-07-01
End date: 2024-12-31
Duration (months): 42.0
Total project cost (EUR): 6669677.74
EU funding (EUR): 3491307.13
Participants: 24
Project status: SIGNED

The overall purpose of the SUSTENANCE project is to set up sustainable energy systems for achieving novel carbon neutral energy communities. The project focus on the development of smart technological concepts ensuring a green transition of the energy systems with higher share of local renewable energy and more efficient integrated energy solutions for the electrical, heat, water, waste as well as transportation infrastructure. The set up solutions will at the same time have good socio-economic impact in the local communities and ensure ecofriendly solutions and good infrastructures, which provides support to sustaining the essentials of life. The demonstration activities are set up in four countries: Denmark, India, Netherlands and Poland. These countries has different local energy resources, socio-economic, user behavior, political structures, market conditions and regulations. The project will show how same technical concepts such as coupling of different energy vectors, storage solutions, demand response, intelligent control schemes and digitalization can be applied to all demonstration cases despite the huge differences in the local conditions and regulations. Road maps will be set up based on these technical solutions together with guidelines for methods for user engagement and ensuring cooperation among the users in relevant cases leading to cooperatives. Finally, business cases will be set up for the different demonstration sites seen from both user perspective, small enterprises and utility point of view taking into account the local conditions. In this way, synergy effects with inputs from the different demonstration sites are expected and the results give abundant possibilities for maximum impact and replication in other local communities in the four countries as well as in societies worldwide.

Keywords: demand response control systems,multi energy systems,integrated energy vectors,carbon neutral systems
The first portable genetic analyser for crop pathogen detection (Terrabio)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Poland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-07-01
End date: 2019-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The incidence of food recalls has not declined, over the past few decades, which is troubling. To address this, food producers continually evaluate their processes to ensure the highest quality and profitability, through a significant focus on risk management. Risks like drought and flood are considered acts of nature to which consumers are forgiving; however, other risks, such as releasing contaminated food items to consumers, is viewed by the public as preventable, less forgivable and dangerous. There is a need for technologies that will enable precision agriculture and integrate controlled release fertilisers, pest and weed management, and weather forecasting. The aim of this project is to further develop a product that will fully satisfy the demands of the agri-food market. The Terrabio instrument is the first portable analyser that is easy enough to be used by those with no training in microbiology or molecular biology. Terrabio is based on a novel, patent-pro¬tected technique and delivers fast pathogen detection onsite so that producers can monitor their fields and prevent damage in a timely manner. The Terrabio product will empower food producers to change business practices and allow them to deliver fresher and safer foods to consumers while maintaining economic efficiencies. These benefits will translate into economic gains for the users as fast and precise pest monitoring will limit agrochemical use and contribute to higher yields and fewer losses. The aim of the SME Instrument Phase 1 feasibility study is to optimise and validate the business plan that will guide the exploitation and commercialisation of our product. Terrabio’s technology is suitable for pathogen testing in any biological sample and has a wide range of diagnostic application. The success of this project will provide Terrabio with the possibility to scale up fast, cooperate with leaders in agriculture and food safety markets, and address global challenges in food safety.

Keywords: risk management,sustainable pesticide use,pest management,precision agriculture
Time-scale bridging potentials for realistic molecular dynamics simulations (TIME-BRIDGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-07-01
End date: 2020-12-31
Duration (months): 66.0
Total project cost (EUR): 1499375.0
EU funding (EUR): 326250.0
Participants: 2
Project status: CLOSED

The possibility to produce materials with ultra-strengths could revolutionize materials design. Since 80 years ultra-strength materials are known to exist only theoretically. Now, new experiments show that traditional believe can be overcome by nanostructured design. Yet, while selected experiments point towards this scientifically fascinating and technologically important possibility (e.g., for advances in structural and functional materials), further progress crucially relies on insight from theoretical simulations. The most successful simulation tool is molecular dynamics. Recent advances in hardware allow to tackle trillions of atoms making a comparison with nano-experiments almost possible. The nagging problem is, however, a huge time-scale gap of up to ten orders of magnitude and none of the presently available approaches is able to cope with this discrepancy. TIME-BRIDGE aims at solving the time-scale problem by borrowing a concept well known and developed in the field of first-principles simulations: the pseudopotential ansatz. In first principles simulations a similar time scale gap exists between slow and fast moving electrons. The solution is to capture the effect of the fast electrons only effectively within a pseudopotential while retaining the motion of slow electrons important for chemical bonding. An equivalent pseudopotential ansatz is envisioned to be applicable to the fast thermal motion of atoms, the origin of the time scale problem. Capturing the thermal motion in an effective potential will allow to simulate the relevant mechanical processes occurring on microsecond and second time scales. In TIME-BRIDGE high risk and high gains apply: the physics of electrons is distinct from the atomic motion possibly making the pseudopotential ansatz non-transferable, but—based on PI’s distinguished expertise and his recent methodological advancements—a route to bridge the fundamental time scale gap might arise.

Keywords: molecular dynamics simulations,first principles calculations,finite temperatures,method development,numerical algorithms,ultra strength,mechanical properties,computational materials design
Filter-less water-based Air Pollution Abatement system (APA)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-02-01
End date: 2020-12-31
Duration (months): 35.0
Total project cost (EUR): 1827955.0
EU funding (EUR): 1279568.5
Participants: 1
Project status: CLOSED

APA is a filter-less air pollution abatement system for a wide range of polluting emission from industrial processes. Through its efficient method of cleaning and purifying air, APA lowers the emissions of industries thereby decreasing the occurrence of health issues for employees and creating a safer workplace. It contributes to a reduction of pollutants released in the environmental thereby enabling a greater sustainability of the manufacturing industry. APA cleans air within a radius of 25m and is a scalable system that can be customised for different applications, either standalone or in a network. Pollutants removed from the air include: particulate matter; heavy metals; hydrocarbons; pollen; spores; NOx; SOx; CO2. The system utilises our patented water-based, chemical-free, centrifugal force process producing a water-based waste. In comparison to other systems, the filter-less technology greatly reduces manufacturing and maintenance costs. Along with this, APA is unique in that it can be positioned both in working environments and on the discharge points of industrial processing machines, this means workers benefit from a more direct impact of the air purification gaining a healthier working environment. The technology has reached a TRL7 and has been tested in various operational environments demonstrating proof of concept and significant air pollution reductions (until 99.99% on PM10). APA addresses an estimated market of about 2 million factories in Europe. During the project we will define the final design of the APA system and will carry out the pre-industrialized production, and will deploy 20 machines in the end-user's site for in-field validation. Phase 2 project aims also at establishing and launching the industrial operation, at activating the existing commercial channels as well as securing further commercial cooperation with partners in Europe.

Keywords: air pollution,air pollution abatment,air purification,filter less,urban pollution reduction,industrial emission reduction,air cleaner
Motion Picture Grammatical Rating System for Infants and Toddlers (MOPIGRASFIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2018-08-09
Duration (months): 23.0
Total project cost (EUR): 187310.85
EU funding (EUR): 187310.85
Participants: 1
Project status: CLOSED

The use of infant-directed media has increased substantially, from 17% in the 1990s to now over 50% in the first year of life although this use is highly controversial. Current motion picture rating systems in Europe only target viewers above 3 years, and only in terms of content. Infant-directed videos include a wide range of cinematic techniques which require film literacy to understand. It is therefore crucial to investigate comprehensively the role of such techniques on infant attention so as to ascertain the impact videos may have on the developing brain. The overall objective of the proposed research is to assess systematically the role of: (a) cinematic techniques, (b) viewing experience and (c) cognitive development on the comprehension of moving images and, on the basis of the findings, (d) to suggest an "age-appropriateness" rating scheme for infants and toddlers (e.g. 12m+, 24m+) for audiovisual material. Six-, 12-, 18-, 24- and 36-month-old young children will be categorized into two groups according to the extent of their viewing experience and tested in a cross-sectional study, the findings of which will have important implications for children’s mental development by identifying the age-appropriate cinematic techniques for comprehension of moving images, which may be suitable educational media for infants. This proposal falls squarely within the topics emphasized in the EU 7th Framework socio-economic sciences and humanities themes; it is multidisciplinary, combining film studies, vision sciences, cognitive psychology, developmental psychology, and developmental neuroscience, and will yield significant contributions to the film, TV and educational technology fields within the European Research Area.

Keywords: motion picture,film,television,film grammar,young viewers,motion picture age rating system
Predictive Reagent Antibody Replacement Technology (PRe-ART)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Switzerland,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2017-09-01
End date: 2022-05-31
Duration (months): 57.0
Total project cost (EUR): 3588125.0
EU funding (EUR): 3588125.0
Participants: 3
Project status: CLOSED

Predictive Reagent Antibody Replacement Technology (PRe-ART) will create a foundational new technology platform to completely replace conventional antibody technology within medical diagnostics and basic life science research. In a multidisciplinary approach combining basic science, protein engineering and computational prediction, Pre-ART will generate non-antibody components which can be combined in an entirely modular fashion to create molecules that bind any peptide of choice. Such a biotechnological revolution is timely because of current failings in the reagent antibody market, after forty years still based on monoclonal antibodies (mAbs) to detect biomolecules, when 50% of all commercial reagent mAbs have been shown to not function correctly. By combining information science with directed evolution, PRe-ART will ultimately create an encyclopedia of pre-designed and experimentally pre-selected modules (like biological Lego bricks) that may be combined, without any further experiment, to generate unique binding molecules that function as antibody replacements. The PRe-ART vision is that mAbs for many applications in biological research will be replaced over the course of a decade by these designer molecules, with the potential to completely disrupt the industry selling low-quality commercial animal-derived reagent antibodies, and thus create a major new technology for biological research. Thus, PRe-ART will ultimately contribute not only to the health and wellbeing of the EU citizen through improved diagnostic capability, but also to the economy of the EU through the development of myriad detection products, enabled by this foundational platform technology. The interdisciplinary PRe-ART project will achieve this goal by bringing together three leading labs from different fields, two of which are lead by women PIs, whose joint efforts will achieve this breakthrough S&T target. The PRe-ART project thus closely addresses all specific challenges of the call.

Keywords: proteomics,protein design,antibodies,armadillo repeat proteins,computation,molecular modeling,proximax,biological engineering,biotechnology,directed evolution,diagnostics
Local Indicators of Climate Change Impacts. The Contribution of Local Knowledge to Climate Change Research (LICCI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-06-01
End date: 2023-05-31
Duration (months): 60.0
Total project cost (EUR): 1999999.0
EU funding (EUR): 1999999.0
Participants: 1
Project status: SIGNED

In the quest to better understand local climate change impacts on physical, biological, and socioeconomic systems and how such impacts are locally perceived, scientists are challenged by the scarcity of grounded data, which has resulted in a call for exploring new data sources. People with a long history of interaction with the environment have developed complex knowledge systems that allow them to detect local impacts of climatic variability, but these insights are absent in climate change research and policy fora. I will bring insights from local knowledge to climate research by 1) providing data on local climate change impacts on physical (e.g., shrinking glaciers) and biological systems (e.g., phenological changes) and on perceptions of climate change impacts on socioeconomic systems (e.g., crop failure due to rainfall patterns change) and 2) testing hypotheses on the global spatial, socioeconomic and demographic distribution of local climate change impacts indicators. Research will last five years. The first 18 months, Preparation, I will train a team who will develop and implement a data collection protocol and design a web-based platform where citizens can enter information on local climate change impacts indicators. During the following two years, Data collection, we will train 40 external PhD students to collect project’s data in data-deficient regions and disseminate the platform. During the last 18 months, Analysis, the core team will use spatial matching and multivariate analysis to test hypotheses related to the spatial, socioeconomic, and demographic distribution of local climate change impacts indicators. External PhD students will analyse local data. Dissemination will be transversal to the project. This project will fill theoretical and spatial gaps on climate change impacts research. It will also improve local capacity to respond to climate change impacts and help bridge epistemological differences between local and scientific knowledge systems.
Cell-free reconstitution of autophagy to dissect molecular mechanisms (AutoClean)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-06-01
End date: 2025-05-31
Duration (months): 84.0
Total project cost (EUR): 1955666.0
EU funding (EUR): 1955666.0
Participants: 1
Project status: SIGNED

Autophagy, a lysosomal degradation pathway in which the cell digests its own components, is an essential biological pathway that promotes organismal health and longevity and helps combat cancer and neurodegenerative diseases. Accordingly, the 2016 Nobel Prize in Physiology or Medicine was awarded for research in autophagy. Although autophagy has been extensively studied from yeast to mammals, the molecular events that underlie its induction and progression remain elusive. A highly conserved protein kinase, Atg1, plays a unique and essential role in initiating autophagy, yet despite this pivotal importance it has taken over twenty years for its first downstream target to be discovered. However, whilst our identification of the autophagy related membrane protein Atg9 as the first Atg1 substrate is an important advance, the molecular mechanisms that enable the extensive remodelling of cellular membranes that occurs during autophagy is still completely undefined. A detailed knowledge of the inputs and outputs of the Atg1 kinase will enable us to provide a definitive mechanistic understanding of autophagy. We have devised a novel permeabilized cell assay that reconstitutes the pathway in vitro, allowing us to recapitulate key steps in the autophagic process and thereby determine how the individual steps that lead up to autophagy are controlled. We will use this system to dissect the functional role of Atg1 kinase in autophagosome-vacuole fusion (Objective 1), and to determine the origin of the autophagic membrane and the role of Atg1 in expanding these (Objective 2). To reveal how Atg1/ULK1 kinase is activated in mammalian cells, we will apply the unique and carefully tailored synthetic in vivo approaches that we have recently developed (Objective 3). By focusing on the activation of the Atg1 kinase and the molecular events that it executes, we will be able to explain its central role in regulating the autophagic process and define the mechanistic steps in the pathway.