Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Next Generation Health Technology Assessment to support patient-centred, societally oriented, real-time decision-making on access and reimbursement for health technologies throughout Europe (HTx)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Research and Innovation actions
Countries involved: Spain,Switzerland,Bulgaria,Finland,Sweden,Belgium,Hungary,France,Netherlands,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom
Call: HTA research to support evidence-based healthcare (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 9640775.0
EU funding (EUR): 9640775.0
Participants: 17
Project status: SIGNED

HTx will create a framework for next generation Health Technology Assessment (HTA) that supports patient-centred, societally oriented, and real-time decision-making for integrated healthcare throughout Europe. HTx will focus on therapeutic areas with high unmet need for which HTA information has to be provided on complex and personalised combinations of health technologies. Based on a select number of relevant case studies, HTx will enhance methods for integrating evidence from RCTs and real-world data (RWD). HTx will also augment statistical and econometric methods for generating robust estimates of effectiveness and cost-effectiveness in order to support relevant HTA decision-making for these complex and personalised combinations of health technologies. HTx will also contribute to improving methods to support personalised treatment advice fitted for sharing with patients and their physicians. This includes the development of statistical and econometric approaches and artificial intelligence/machine learning methods for forecasting treatment effects in specific groups of patients. Simultaneously, in close collaboration with the European Network for HTA (EUnetHTA), HTx will improve synergies between regulatory agencies, HTA bodies and clinical guideline developers. This will include the translation of HTx methods into already existing European guidelines, most prominently those developed by EUnetHTA. HTx will also support initial efforts to discuss reimbursement and funding models that facilitate controlled access to and the pricing of these complex health technologies. Finally, we will evaluate the transferability of HTx results into all EU Member Countries especially in Central and Eastern European (CEE) Countries and promote the dissemination of HTx results to the different European stakeholders with a special focus on the patient community.

Keywords: real world data,data synthesis,eunethta,personalised treatment
The first simple monitoring device for Parkinson and other Tremor diseases (Tremipen)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Austria
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Many health conditions like diabetes or hypertension have simple measurement devices. However, there is no equivalent for Parkinson´s Disease (PD) or Essential Tremor (ET), making an accurate clinical diagnosis and follow-up of these diseases a challenge. Instead, current check-ups and diagnosis of PD/ET are mostly carried out using subjective methods based simply on observation during visits (every 6 months). Even though there are some traditional solutions for Tremor monitoring, such as Electromyography or accelerometers, these are large devices which are expensive, take long time to use and provide no direct information for the patient, and though new solutions are being developed (such as 24h devices or phone apps), these are not 100% accurate, nor certified for their medical use. Moreover, none of the existing/developing solutions consider the psychological affection of patients, who feel helpless exposed to the disease and often suffer depressions. Our goal with Tremipen is to offer the first simple, small, easy-to-use, reliable and cost-effective device for PD and ET home-monitoring: a pen-like device, which just needs to be held for 60 seconds a day, to register the amplitude of the tremors. This information (which is shown in a display for the patients to see) is also stored for the subsequent analysis of doctors (with a tailored software), enabling a monitoring of the disease between visits. In this way, Tremipen does not aim to substitute doctors, but to act as a tool to help monitoring and treatment, while promoting patients´ empowerment and improving patients’ life quality for the over 10 million patients of PD/ET worldwide. Moreover, through this project we aim to boost the growth and competitiveness of our company: Early forecast predict sales of over 26,000 units 3 years after commercialization, resulting in €10.1 Million of accumulated profit.

Keywords: parkinson s,tremor,monitoring,device,pen like,patient empowerment
XSpectra: The Most Advanced Real Time Food Contaminants Detector (XSpectra)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-04-01
End date: 2021-09-30
Duration (months): 30.0
Total project cost (EUR): 3279961.25
EU funding (EUR): 2276722.88
Participants: 1
Project status: CLOSED

Xnext is a small Italian high-tech company that has the ambition of revolutionizing the quality inspection in the food sector and the ultimate goal of providing a decisive contribution for the solution of food contamination problems. We aim at succeeding thanks to XSpectra®, the most advanced real time inspection detector. XSpectra® is a disruptive technology as it overcomes all the weaknesses of conventional technologies, thus determining a relevant technological leap compared to all the existing solutions. Based on X-ray multi-spectrum analysis, XSpectra® is capable, like no other technology, to analyze real time the physical-chemical features of the materials and identify foreign bodies currently not detectable. The result of over 8 years of R&D, it’s a very complex system, combining 3 high innovations, all industrialized in-house: Photonics, Nuclear Electronics and Deep Learning Artificial Intelligence Algorithms. XSpectra® is beneficial for the food producers as it improves significantly the production efficiency (minimizing the product batch discard as well as the costs for product recalls); for the consumer as it guarantees the highest safety standards for the quality of foodstuff; for the environment as it helps to reduce significantly the amount of wasted food from the production line. XSpectra® has successfully completed the industrial prototype testing and is now installed for a field test on a production line. At the end of the project we will release the final industrial product and begin the commercialization worldwide. Thanks to high versatility of the system and the chemical-physical characterization capability, XSpectra® can be applied in several other fields: Pharma, Non-Destructive-Tests, material recycling, security controls, just to mention a few. Xnext intends to exploit the cash generation coming from the application in the food sector to support the application of XSpectra® in other sectors that also need to improve the quality standar

Keywords: xray,real time control,non destructive testing,foreign body detector,nuclear,electronics,industrial measurement
Exciton-Phonon Coupling from First Principles (EXPHON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Optical properties of materials are most relevant for a large variety of technological applications, ranging from photovoltaics over various spectroscopy techniques to LEDs and displays. In optical spectra, microscopic quantum many-body effects like excitons, i.e. coupled electron-hole-pair excitations, are measurable at a macroscopic scale and crucially determine the materials properties. Hence, a deep understanding of excitons constitutes an indispensable driving force for innovation in optics and optoelectronics. The state-of-the-art parameter-free theoretical description of excitons is based on the ab-initio methods of many-body perturbation theory. The present theoretical standard approach for exciton spectra, which relies on the Bethe-Salpeter equation, takes only the static electronic screening of the electron-hole-pair interaction into account. The coupling of excitons to phonons and, hence, polaronic screening contributions are completely omitted. However, the exciton-phonon coupling is crucial for the qualitative and quantitative understanding of exciton spectra in materials with strong polaronic effects, such as many technologically highly relevant oxides. EXPHON will close this gap of knowledge. It focuses on the ab-initio description of excitons in systems with strong polaronic lattice screening. The key objectives are (i) the development of a theoretical method that takes polaronic screening of the electron-hole interaction into account, (ii) the implementation of this theoretical scheme in an ab-initio software package, and (iii) the calculation of reliable exciton spectra for materials with strong polaronic effects. This will be a major step forward towards a full description of the interplay between electronic and lattice degrees of freedom in semiconductors.

Keywords: ab initio calculations,excitons,phonons,many body perturbation theory,density functional theory,optical absorption,electronic structure
Boosting metabolism in T cells: a tool to improve T cell therapy for chronic lymphocytic leukemia patients (BOOTCAMP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands,United States
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-08-01
End date: 2025-07-31
Duration (months): 60.0
Total project cost (EUR): 1997662.0
EU funding (EUR): 1647662.0
Participants: 3
Project status: SIGNED

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. Novel targeted drugs are effective, but not curative. Moreover, prolonged use is associated with development of resistance, toxicity, and high economic cost. Allogeneic stem cell transplantation, which evokes a T cell mediated response, is potentially curative yet is associated with high graft-vs-host-related mortality. Therefore, an autologous T cell-based approach, e.g. chimeric antigen receptor T cells (CAR-T), is a highly promising strategy. However, in contrast to the success of CAR-T cells in aggressive leukemia, their effect in CLL is limited owing to a largely unexplained acquired T cell dysfunction in this disease setting. I recently found that CLL cells impose a reduction in mitochondrial fitness and altered glucose metabolism on T cells, which may underlie the acquired T cell dysfunction. Lending clinical significance to this finding, I observed that the success of CAR-T treatment in CLL patients is highly associated with their mitochondrial biogenic capacity. I therefore hypothesize that improving mitochondrial fitness of CAR-T cells may offer a path to cure CLL. I aim to: 1. Characterize the molecular mechanisms of metabolic alterations in CLL-derived T cells 2. Elucidate how CLL cells reprogram T cells metabolism 3. Increase mitochondrial biogenesis and fitness in CAR-T cells to improve therapeutic efficacy To achieve these goals, I will conduct an array of complementary molecular, metabolic, and genetic assays using patient samples and a murine model of CLL. To address therapeutic potential I will study murine and human CAR-T cells in which metabolic processes will be manipulated. This project provides crucial insight into the interplay between CLL and T cells, and the underlying failure of cancer immune surveillance. This may lead to metabolism-based curative autologous T cell based therapies in CLL, which may also be relevant for other malignancies.
Linking atomic-scale properties of 2D correlated materials with their mesoscopic transport and mechanical response (LINKSPM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Spain
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-10-01
End date: 2023-09-30
Duration (months): 60.0
Total project cost (EUR): 1734625.0
EU funding (EUR): 1734625.0
Participants: 1
Project status: SIGNED

Fundamental material properties become highly susceptible to external perturbations in low dimensions. This presents tremendous new opportunities for manipulating the behavior of novel 2D layered materials and ultimately achieving unprecedented control over their performance when integrated into highly specific functional devices. However, strategies that enable such control are sorely lacking to date and remain an outstanding challenge for the materials science community. Progress here requires of a comprehensive microscopic picture of the fundamental properties of 2D materials in clear connection to their macroscopic behavior, a knowledge that is still missing due to the lack of experimental techniques that simultaneously probe multiple length regimes. The main objective of the proposed research is to demonstrate control over the electronic ground states of 2D materials via external strain and electromagnetic fields to build links of applicability for signal processing in electromechanical nanodevices. We will focus on 2D correlated materials exhibiting collective electronic phases such as superconductivity, which respond dramatically to external perturbations. The project aims to understand the interplay between these external stimuli and microscopic electronic phases, and to unambiguously correlate them with mesoscopic electrical transport and mechanical response. This project comprises three research thrusts: (i) Development of new instrumentation that provides a direct way to correlate atomic-scale and mesoscopic properties of materials, and to establish links between (ii) the electrical conductivity and (iii) the mechanical response of 2D correlated materials with their atomic-scale structure and stimulus-dependent electronic phase diagram. This project has the potential to transform this field by providing new pathways to control the behavior of layered nanostructures.

Keywords: 2d materials,electron correlation,phase transitions,mechanical properties,scanning probe microscopy,nanoresonators
A New Paradigm for Efficient and Modern Rail Signalling (LEDVAR-Z)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-06-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Electrans’ aim is to improve the current rail signalling system and to take a step forward towards the full implementation of the European Rail Traffic Management System (ERTMS). The current rail signalling system remains shockingly antiquated throughout the world. Firstly, the electronic signal’s messages are fixed during production. This means that customised signals must be designed, ordered and manufactured every time needs change. Secondly, there is a huge amount of cables and interlocking stations that require installation and maintenance and increase operational expenditures. Thirdly, the current railway monitoring system is rudimentary and requires unnecessary energy consumption. The solution we propose, LEDVAR-Z, is an innovative ITC system that will standardise and modernise railway signalling, making it more efficient. It is composed of high-quality LED signals able to display any type of light or message and software that intelligently monitors and controls what is displayed. Fewer interlocking stations will be needed and they can communicate with signals through fibre optic cables or radio networks. As a result, LEDVAR-Z will drastically reduce costs for railway companies, streamline rail projects and improve rail traffic control management. The project will have a great impact on our company: we will increase international market share up to 58%, enjoy cumulative profits up to €25M and be able to hire 55 employees by 2024.

Keywords: railway,signalling,led lights,rail,security,train,tram
Sizing Up PD: Cavity-enhanced Characterisation of Single Biomarkers in Human Biofluids (SUPD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-02
End date: 2024-10-31
Duration (months): 36.0
Total project cost (EUR): 289732.8
EU funding (EUR): 289732.8
Participants: 2
Project status: SIGNED

Parkinson’s disease is the most common movement disorder caused by neurodegeneration, for which there is no cure, no way of modifying the disease and no clinically accepted diagnostic tool. In the brain, the intrinsically disordered monomeric protein α-synuclein misfolds, aggregates and accumulates to form proteinaceous inclusions termed Lewy bodies. This process forms ‘oligomers’, intermediates in the aggregation pathway that are strongly implicated in the cellular toxicity that causes the disease. Oligomers are exceedingly challenging to study with traditional biophysical techniques because of their low abundance and variability in size, structure and stability. My research proposal aims to develop a new method capable of measuring the size and structural properties of single oligomers in human cerebral spinal fluid. By employing technologies in the field of cavity-enhanced spectroscopy and combining these with existing tools in single-molecule fluorescence I will investigate how the properties of oligomers in cerebral spinal fluid differ between healthy and Parkinson’s disease patients. In order to determine the molecular origins of Parkinson’s disease we need a comprehensive understanding of these pathogenic species. Achieving this goal will enable us to develop an early diagnostic tool which in turn will generate opportunities for therapeutic intervention.

Keywords: single molecule methods
Anti-Colonial Solidarity: Analytical Clarification through Historical Reconstruction (ACSol)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2024-03-30
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

The overall objective of my research programme is to develop an account of anti-colonial solidarity grounded in the global history of political thought, and to work out anti-colonial solidarity’s contribution to contemporary political theory. I take my cue from the recent emphasis on the practical dimensions of solidarity in analytic political theory. On this account, solidarity is best understood as a particular mode of action, through which agents attempt collectively to redress the effects of injustice or to contest the structures that produce and sustain it. But my project is motivated by the following hypothesis: that the history of anti-colonial solidarity is best able to clarify solidarity’s practical and global dimensions. The first theories of solidarity were primarily concerned with nation building in modern France. But against and alongside these classical accounts, the central figures of my research project developed alternative models of solidarity in anti-colonial movements explicitly oriented transnationally and globally. Cuban revolutionary José Martí, Haitian statesman Anténor Firmin, and American Pan-Africanist W.E.B. Du Bois used solidarity to link local struggles against colonial domination around the world. By investigating these anti-colonial writers, and their understanding of the relation between local, transnational, and global political struggles, my research: (i) contributes to and expands on recent developments in analytic political theory by identifying anti-colonial solidarity as a distinct type of solidarity. In doing so, I (ii) develop a new perspective on solidarity that exceeds the ‘top-down’ models of cosmopolitanism that have long dominated political theory. I also (iii) excavate a crucial but neglected chapter in the global history of this contested political value.