Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dynamics and heterogeneity of early viral infection (VirIm)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Viruses are simple replicative units built from two components: a nucleic acid and a small number of associated proteins. Upon entering a cell, viruses co-opt the hosts machineries to copy their genetic material, while shutting down the hosts antiviral immune response. The success of viral infection differs dramatically from cell to cell through poorly understood mechanisms, resulting in heterogenous propagation through tissues, and ultimately, heterogeneous disease progression. Although viruses have been studied for decades, the earliest steps of cellular infection have remained hidden, because only a few viral molecules are present at this stage, which presents formidable challenges for molecular analyses. Yet these initial events are critical for achieving a successful infection; transcription, translation and replication must be perfectly balanced to rapidly scale virus production before antiviral signalling pathways are activated. To overcome this barrier, we recently developed a first-in-kind imaging technology for simple positive-sense single stranded RNA (+ssRNA) viruses that transforms our ability to visualize early viral infection processes. In this proposal, we will expand our single–molecule toolbox to gain molecular insights into early viral infection of the more complex group of negative-sense RNA (-ssRNA) viruses. We will focus on the respiratory syncytial virus (RSV), a -ssRNA virus which can be deadly in infants and vulnerable adults, and lacks effective treatments. Specifically, we will determine i) how viral transcription and replication are coordinated on single viral genomic RNA molecules to optimize early viral propagation, ii) what causes the early viral infection heterogeneity, and iii) how heterogeneity in early viral infection impacts infection outcome. Using our novel approaches, we will gain a deep understanding of viral biology, which will eventually inform therapeutic interventions.

Keywords: single molecule imaging rna virus quantitative biology
SCIENCE COMES TO TOWN – UNITED TOWNS IN SCIENCE (UNITES)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Germany,France,Croatia,Belgium,Norway,Italy,Portugal,Spain,Poland,Malta
Call: Science comes to town (HORIZON-WIDERA-2024-ERA-02, 2024)
Start date: 2025-06-01
End date: 2027-06-30
Duration (months): 25.0
Total project cost (EUR): 6000000.0
EU funding (EUR): 6000000.0
Participants: 68
Project status: SIGNED

Being the 1st edition of Science Comes To Town (SCTT), UNITES will offer an inspiring and entertaining programme with more than 1,000 activities, bringing together over 70 partners in the cities of Kiel, Brest and Split and their regions by connecting scientific institutions, innovation ecosystems and citizens across Europe. More than 20,000 scientists are available to the partners for the implementation of UNITES. The cities share a similar geographic position as the largest coastal cities of their countries, yet still only medium-sized, peripheral and distant from any large urban agglomerations. They are all vibrant and renowned university cities with excellent town-and-gown relations, enthusiastic about hosting large science outreach events, including national and international science competitions, and experienced in organising large public festivals attracting several millions of visitors. The common profile results in shared local societal challenges and in a distinctly European approach to finding solutions. They have long participated in EU’s biggest flagship initiatives like the EU Missions and the European Researchers’ Nights. However, what truly UNITES the cities is the European University Alliance SEA-EU, where they have built a transnational network of nine universities and their city administrations. Together with the SEA-EU satellite events, UNITES' sphere of activity stretches from the Arctic Ocean to the Mediterranean and will attract over 1.5 Mio visitors and raise awareness of SCTT among more than 25 Mio people. A well-planned marketing strategy will promote SCTT across Europe, supported by the international visibility of EUCYS and EU TalentOn. UNITES will carefully select locally relevant topics and incorporate existing and newly developed interactive formats to make the year engaging for all participants. Along with its train-the-trainer workshops and a participatory approach, this will guarantee the quality and long-term impact of the project.

Keywords: increased trust in science,science for society,scientific activities and public engagement,randi impact,brand implementation,brand promotion,connect citizens and randi community,science competition
Tracking Nanomaterial Performance, Towards Digital Twins of Quantum Dots Under Loading (TRACK THE TWIN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium,Spain,Switzerland,Germany,Italy,Netherlands,Israel
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-12-01
End date: 2028-11-30
Duration (months): 48.0
Total project cost (EUR): 4218014.06
EU funding (EUR): 3989239.2
Participants: 14
Project status: SIGNED

Quantum dots (QDs) exemplify the successful transfer of innovative nanomaterials from a lab-scale invention to a technology that offers better and more power-efficient electronic devices, or makes buildings generate renewable energy. Such implementations, however, keep QDs under permanent loading, such as constant illumination, elevated temperature or exposure to environmental agents. Efforts to make QDs resilient against loading-induced ageing and loss of performance are time-consuming and costly. Track The Twin addresses this problem through a research and training program aimed at creating and using QD digital twins (QDDTs). Focused on the case of QDs under illumination, this goal creates an exceptionally rich environment to form a new cohort of early-stage researchers (ESRs) in nanomaterials. Trained as experts in the latest methods of synthesis, structure analysis and time-resolved spectroscopy – from infrared to x-ray - and computational materials science, ESRs will learn to join forces to reach the common goal of demonstrating loading-resilient QDs synthesized according to best QD structures as predicted by the QDDTs. To facilitate such a collaborative endeavor, all ESRs will be trained to use and co-develop a common data platform and they will be permanently exposed to the diversity of environments needed to implement together a QDDT. Thanks to the deep collaboration between word-leading academic beneficiaries and start-up companies in nanomaterials and computational chemistry, scientific training is complemented by extensive transferrable skills training. Moreover, the timeliness of the research and training topic – digital twins in materials science - enables the consortium to implement a proactive outreach strategy, which extends from a personal outreach activities of the ESRs to QD technology broadcasting to reach a broader field of industrial actors and policy makers and ensure the network has lasting impact on nanomaterials research and innovation.
The online-offline nexus in cybercrime: Examining online and offline pathways into and out of cybercrime (CybercrimePathways)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-02-01
End date: 2029-01-31
Duration (months): 60.0
Total project cost (EUR): 1499875.0
EU funding (EUR): 1499875.0
Participants: 1
Project status: SIGNED

Cybercrime is on the rise and the digitization of crime raises an array of fundamental questions. The CybercrimePathways Programme focuses on one of the major issues in criminology today: changing offline and online pathways in and out of cybercrime. Individuals do not become cybercriminals overnight. They tend to move through different stages, with each stage bringing them a little closer to crime involvement. The opposite is true for desistance, the process of quitting crime, whereby each step takes individuals further away from criminal activities. Together, these stages are called pathways. The overarching aim of this study is to acquire fundamental knowledge on pathways into and out of cybercrime. Without knowledge about the pathways, it remains unclear if existing theories can still be used to explain cybercriminal activities. A recent systematic review of the literature shows that the empirical evidence on the factors leading into cybercrime is often incomplete, weak, and fragmented, and that there is a gap between insights from qualitative studies and quantitative studies on the potential drivers of recruitment. The Programme will go beyond the existing literature and propose a mixed method design that combines much-needed explorative qualitative insights with rigorous quantitative field experiments. Using unique qualitative data (a combination of interviews with criminal and ethical hackers, and police data), mechanisms will be distilled and experimented in studies with rigorous experimental designs. Criminological research using online platforms is scarce; however, the pioneering work conducted by both my colleagues and me confirms that these platforms are most promising for performing experimental studies. To reconceptualize and future-proof traditional theories, the Programme will study both cyber-dependent and cyber-enabled crimes, which will enable us to identify the similarities and differences between those two types of cybercrime.

Keywords: cybercrime pathways desistance
Virus related biomarkers to improve management of chronic conditions (VIROMARKERS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Innovative Health Initiative
Action type: Research and Innovation actions
Partnership: IHI (JU-JTI)
Countries involved: Italy,Germany,United Kingdom,Sweden,Belgium
Call: Clinical validation of biomarkers for diagnosis, monitoring disease progression and treatment response (HORIZON-JU-IHI-2024-07-single-stage, 2024)
Start date: 2025-02-01
End date: 2028-01-31
Duration (months): 36.0
Total project cost (EUR): 4358845.0
EU funding (EUR): 2329503.75
Participants: 20
Project status: SIGNED

The unifying aim of VIROMARKERS is to define virus related biomarkers to improve management of chronic diseases, including biomarkers of response to antiviral treatment of persistent viral infections and virome features as indicators of disease progression in immunosuppressed people. The project has the following objectives: 1. To demonstrate a novel bioinformatics method for prediction of HIV-1 susceptibility to broadly neutralising antibodies based on the HIV-1 gp120 sequence. 2. To demonstrate novel HDV biomarkers (HDV-RNA, HBsAg isoforms and HDV genotype) to predict treatment response to the recently approved anti-HDV bulevirtide. 3. To validate serum CMV-RNA as a biomarker of CMV infection/reactivation to optimise the correct timing for preventive strategies in patients undergoing hematopoietic stem cell transplantation. 4. To validate the torque teno virus DNA as a prognostic biomarker for CMV disease in immunocompromised patients. 5. To validate total and intact cellular HIV DNA as a biomarker of HIV infection status to guide novel antiviral strategies. Validation or demonstration of several technologies required to measure the candidate biomarkers is an integral part of the project objectives. In particular, this refers to the following diagnostic tools: • dPCR as a tool for HDV quantification • NGS platform for HDV sequencing • qPCR diagnostics for CMV-RNA quantification • IPDA suitable for detection of intact HIV-DNA in any viral subtype • qPCR diagnostics for TTV-DNA Leveraging on the regulatory expertise present in the consortium, VIROMARKERS will define the regulatory pathway for each of its outcomes and will generate the experimental data necessary to move prototype methods and tools to regulatory approval. Overall, VIROMARKERS, with its public private partnership nature, will make available for healthcare providers and for researchers robust and fit-for-purpose biomarkers and linked technologies enabling their clinical use in response to important unmet clinical needs with, in the end, an important impact also for patients. VIROMARKERS is supported by the Innovative Health Initiative Joint Undertaking (IHI JU). The JU receives support from the European Union’s Horizon Europe research and innovation programme and COCIR, EFPIA, Europa Bío, MedTech Europe, and Vaccines Europe

Keywords: novel hiv treatments,hiv bnabs,hdv patients management,cmv disease,hematopoietic stem cells transplanted patients
Musical Metaverse made in Europe: an innovation lab for musicians and audiences of the future. (MUSMET)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Sweden,France,Switzerland,Austria,Spain,Poland,United Kingdom
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-02-01
End date: 2029-01-31
Duration (months): 48.0
Total project cost (EUR): 3000000.0
EU funding (EUR): 3000000.0
Participants: 16
Project status: SIGNED

The grand challenge of this project is to create the basis for a paradigm shift in the way music is performed and experienced, by leveraging the new creative possibilities offered by the emerging Musical Metaverse. The consortium aims to achieve this ambitious challenge by means of i) a socio-cognitive breakthrough, by gaining a deep understanding of the emerging needs and concerns of contemporary musicians and audiences via collaborative design activities and neuro-physiological measurements; ii) a technological breakthrough, by developing radically novel concert platforms and devices that can exchange information among each other via ultra-reliable low-latency wireless networks, with privacy and security constraints; iii) a musical breakthrough, by creating novel concert formats that exploit the technological and socio-cognitive breakthroughs. This project uses an interdisciplinary methodology that combines Human-Computer Interaction, Engineering, Cognition, and Music, drawing from the scientific excellence of the partners. Industrial partners will provide know-how for proof of concept prototypes. Through this disruptive approach, the project will provide a pipeline to the technological development of a new class of musical interfaces and Musical Metaverse ecosystems, whose features will go substantially beyond current systems. The proposed approach aspires to effect a step-change in the design of musical interfaces and systems to musically interact online, resulting in a potentially high economic impact on the music industry. The envisioned technological advancements for the musical domain will provide key solutions for true real-time collaborative activities in the Metaverse in general. The project involves theoretical and experimental aspects, and is a high-impact endeavour from which basic science, EU industry and society can benefit.

Keywords: music,metaverse,xr,networking,embedded systems,machine learning
Context-aware adaptive visualizations for critical decision making (SYMBIOTIK)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Luxembourg,Germany,Belgium,Spain,Cyprus
Call: Awareness Inside (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 4485655.0
EU funding (EUR): 4485655.0
Participants: 6
Project status: SIGNED

We live in an era of information overload that impairs objective decision making, especially in time-sensitive contexts. Information Visualization (InfoVis) systems have been used to mitigate information overload, yet they have not yet unlocked their potential in critical decision-making scenarios. From emergency rooms and autonomous cars to operational command centres, a clear understanding and rapid assessment based on the available data can make the difference between life and death. SYMBIOTIK envisions an effortless interaction dialogue between human and InfoVis systems to support decision making processes, inspired by known biological principles and guided by artificial intelligence (AI). Critically, this dialogue requires AI solutions with context awareness, emotion sensing, and expressing capabilities. We propose a novel framework where both the human and the machine cooperate towards a common goal and evolve together. Awareness principles will allow us to engineer complex systems, making them more resilient and more human-centric. We will define an integrative approach for awareness engineering and propose a specific open source implementation. Finally, we will demonstrate and validate the role and added-value of such an awareness framework in two scenarios: supporting novice-to-expert transitions and critical decision making. The awareness principles to be developed in this project can support learning, adaptation, and self-development of intelligent systems over long periods of time, not only in the InfoVis domain. Therefore, SYMBIOTIK has potential to achieve the real breakthroughs needed to bring awareness and emotional intelligence for decision-making tasks in computing systems. The results of the project will benefit a range of stakeholders, from human vision and brain researchers, computer scientists, citizens, as well as research funding bodies and policy makers.

Keywords: infovis decision making adaptive interfaces intelligent systems
Protecting euRopean public spaces against Emergent hoStile drone thrEats thRough an adVanced multidimensional shield and cross-border intelligEnce (PRESERVE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Fighting Crime and Terrorism
Action type: Research and Innovation actions
Countries involved: Spain,Cyprus,Belgium,Romania,Moldova, Republic of,United Kingdom,Greece,France,Finland,Germany,Italy
Call: Open Topic (HORIZON-CL3-2023-FCT-01, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 3998581.0
EU funding (EUR): 3998581.0
Participants: 18
Project status: SIGNED

PRESERVE will deliver a trustworthy, transparent, and easy-to-use Hybrid C-UAS C2 platform supporting Police Authorities with the prevention, early detection and optimal management of operational response against current and emergent threats in drone technology, increasing the security of citizens in public spaces and contributing significantly to the novel EU Counter-UAS policy. By fusing heterogeneous data from an array of physical sensors and online sources, the project will tackle the so far unmanageable threat of weaponised consumer drone swarms through open-source knowledge by non-state actors. PRESERVE will produce s multidimensional shield synthesised into four Products: “Swarm-based C-UAS Arsenal” (P1-SECURE), “Online Drone Intelligence Engine” (ODIN), the “PRESERVE platform” (P3), as the integral solution, and the “C-UAV Training Programme” (P4). PRESERVE platform and products will be validated in near-real environments targeting specific Pilot Use-Cases (PUC), where the real needs expressed by the end-users will be addressed. The flexible and scalable architecture of the PRESERVE platform will allow end-users to implement the platform as a whole or to adopt only specific services and tools based on their operational needs. Theoretical and practical UNITAR-certified trainings, hands-on experience, table-top exercises and field full-scale exercises will boost the uptake of PRESERVE products. The platform development will be governed by ethics, privacy-by-design and AI-trustworthiness, considering EU and relevant national legislations, as well as societal aspects. With four Police Authorities, six Research institutions, four Industry partners (including three SMEs), two Regulatory, Policy, Standard, and Social experts and two Affiliated Entities, the PRESERVE consortium delivers a strong multidisciplinary combination of expertise and novel technologies to meet its objectives.

Keywords: public space terrorism drone swarms darkweb counter drone prevention neutralisation forensics