Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Binaries Escorted By Orbiting Planets (BEBOP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-11-01
End date: 2024-10-31
Duration (months): 72.0
Total project cost (EUR): 1186312.5
EU funding (EUR): 1186312.5
Participants: 1
Project status: SIGNED

Planets orbiting both stars of a binary system -circumbinary planets- are challenging our understanding about how planets assemble, and how their orbits subsequently evolve. Long confined to science-fiction, circumbinary planets were confirmed by the Kepler spacecraft, in one of its most spectacular, and impactful result. Despite Kepler’s insights, a lot remains unknown about these planets. Kepler also suffered from intractable biases that the BEBOP project will solve. BEBOP will revolutionise how we detect and study circumbinary planets. Conducting a Doppler survey, we will vastly improve the efficiency of circumbinary planet detection, and remove Kepler’s biases. BEBOP will construct a clearer picture of the circumbinary planet population, and free us from the inherent vagaries, and important costs of space-funding. Thanks to the Doppler method we will study dynamical effects unique to circumbinary planets, estimate their multiplicity, and compute their true occurrence rate. Circumbinary planets are essential objects. Binaries disturbe planet formation. Any similarity, and any difference between the population of circumbinary planets and planets orbiting single stars, will bring novel information about how planets are produced. In addition, circumbinary planets have unique orbital properties that boost their probability to experience transits. BEBOP’s detections will open the door to atmospheric studies of colder worlds than presently available. Based on already discovered systems, and on two successful proofs-of-concept, the BEBOP team will detect 15 circumbinary gas-giants, three times more than Kepler. BEBOP will provide an unambiguous measure of the efficiency of gas-giant formation in circumbinary environments. In addition the BEBOP project comes with an ambitious programme to combine three detection methods (Doppler, transits, and astrometry) in a holistic approach that will bolster investigations into circumbinary planets, and create a lasting legacy.

Keywords: exoplanets,circumbinary exoplanets,binary stars,exo atmospheres
Janissaries in Ottoman Port-Cities: Muslim Financial and Political Networks in the Early Modern Mediterranean (JANET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Türkiye,Türkiye,Greece
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2026-09-30
Duration (months): 80.0
Total project cost (EUR): 1498389.0
EU funding (EUR): 1078947.75
Participants: 3
Project status: SIGNED

JaNet investigates the economic and sociopolitical role of the Janissaries in the 18th and early 19th centuries through their examination as a complex of interconnected networks in the ‘extended Mediterranean’ (including major Black Sea and Danubian ports). By studying the Janissary corps, the project brings forward a radically new historical analysis concerning, on the one hand, the role of Muslims in the Ottoman and wider Mediterranean commercial economy – a role largely ignored by the bibliography – and, on the other, the processes that led to the creation of diasporas and the dissemination of people and ideas among various Muslim communities in the area. According to our thesis, in the period under examination, the Janissary corps became one of the main channels for the participation of various Muslim social strata of the Ottoman periphery in the Empire’s developing credit market and commercial life, as well as a gateway for their involvement in local and imperial politics. Moreover, it became a platform for the exchange of people, goods, and ideas between different localities covering a vast geographical area. When examined from a Mediterranean perspective, this view allows us to look beyond the information provided by Europe-centered sources and to drastically redefine the sociopolitical and financial role of Muslims in the area, an approach which historical analysis sorely lacks. The project uses a comparative approach to examine a large number of port-cities in North Africa, Egypt, the Aegean, the Adriatic, the Danube, and the Black Sea. The research team – composed of the PI, three senior researchers, five post-doctoral fellows, and two PhD candidates – will study a variety of unpublished sources in Ottoman Turkish, Arabic, Greek, Russian, French, and English. The team will produce a main monograph, a collective volume, several articles, two PhD dissertations, four workshops, one international conference, and a website.

Keywords: history of the ottoman empire,history of the early modern mediterranean,muslim networks,political and economic history
Not Getting Lost in Multi-Scale Maps: Exploring the Anchor Theory in Cartographic Zoom Interactions in the Context of Crisis Management (LostInZoom)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Multi-scale interactive maps such as Google Maps or OpenStreetMap have replaced paper topographic maps for most professional and daily uses. Past research told us how to design paper topographic maps at a given scale to make them readable and understandable by human users. But these rules/guidelines do not apply anymore, and map designers lack guidelines to make maps that are smooth to explore through scales, and it is common for a multi-scale map user to feel lost for a few seconds after a zooming interaction. The LostInZoom project (Not Getting Lost in Multi-Scale Maps: Exploring the Anchor Theory in Cartographic Zoom Interactions in the Context of Crisis Management) seeks to establish a new zooming paradigms for multi-scale maps, based on multi-scale visual landmarks that act as anchors during the zoom. To achieve this novel zooming paradigm, we need new grounding knowledge on how people perceive and understand interactive multi-scale maps, in order to design maps and interaction that make multi-scale explorations smoother. The LostInZoom project will be based on three main pillars. In the first one, we will explore the cognition of multi-scale interactive maps with an experimentation approach, in order to identify the anchors or landmarks that help a map reader locate himself when zooming. In the second pillar, we will design new cartographic generalisation techniques to derive multi-scale maps that magnify the landmarks that are important for multi-scale exploration. Finally, the third pillar will be dedicated to the design of new zooming interactions that focus on these landmarks to smooth even more the zooming exploration.

Keywords: cartography,multi scale visualisation,zoom,scale,risk management,map generalisation,spatial cognition
Multidisciplinary European Joint Doctorate in the Design and Development of Glyco Drugs (PhD4GlycoDrug)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Switzerland,Sweden,Slovenia,France,France,Netherlands
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2017-10-01
End date: 2022-01-31
Duration (months): 52.0
Total project cost (EUR): 3080389.68
EU funding (EUR): 3080389.68
Participants: 8
Project status: CLOSED

The PhD4GlycoDrug consortium has a main goal to offer a European Joint Doctorate educational training network in Glyco-Drug Discovery and Development. The network combines 6 academic partners with long tradition in PhD training and accredited doctoral studies in Organic Chemistry, Medicinal Chemistry, Structural Biology and Pharmacology/Pharmacy. Non-academic partners, 5 SMEs and a research institute also constitute the consortium to offer intersectoral exposure and quality training in transferable skills to entrepreneurial ESRs. So far, only a handful of registered drugs originate from glycoscience area. To pursue an innovative research project in such a timely scientific field of great interest for pharmaceutical industry, a specific set of competences is needed. Our network will focus on delivering expert researchers highly attractive for employment by the European Pharma-industry. To achieve the above objectives the main tasks of PhD4GlycoDrug are: -to recruit and train 12 ESRs in a joint programme of cutting-edge training-by-research in glycoscience with high quality supervision, transferable skills training, and workshops/summer schools, -to start and pursue innovative research projects on specific macromolecular targets that bind and/or modify carbohydrate ligands involving all steps of early drug discovery from target identification and validation, through modern drug design and specific glyco-chemistry, to hit discovery and hit-to-lead development focusing on physico-chemical and ADMET properties, -to build a solid foundation for long-term European excellence in the glyco-drug discovery, -to create a common core standard for a glycodrug curriculum in the Institutions involved, which could potentially become the seed of a common European standard on the subject, and -to establish and foster long-term partnerships that will outlive the project to ensure continuance of the training and research.

Keywords: carbohydrate based drugs,glycoscience,hit discovery,hit to lead development,admet
Reducing Inequalities in Vaccine uptake in the European Region - Engaging Underserved communities (RIVER-EU)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Israel,Germany,Spain,Belgium,Poland,Slovakia,Finland,Greece,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Addressing low vaccine uptake (H2020-SC1-2020-Single-Stage-RTD, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 3299750.0
EU funding (EUR): 3299750.0
Participants: 14
Project status: SIGNED

Health system barriers in vaccine uptake disproportionately affect specific ethnic, religious or cultural minorities across Europe and are therefore a major contributor to low vaccine uptake in these groups. RIVER-EU aims to identify and remove these barriers, specifically focusing on MMR and HPV vaccination in selected underserved communities (migrant community in Greece, Turkish females and Moroccan females in the Netherlands, Ukrainian minority in Poland and Roma community in Slovakia). First, we will analyze health system barriers and enablers to the vaccination of these communities, and then tailor existing interventions or develop new ones, which will be implemented and evaluated. Research findings will be translated in evidence-based guidelines and an educational platform for health care professionals that can be used to address equitable access to vaccination across Europe. We will use the Participatory Action Research approach to involve the target groups and key stakeholders, and to foster collaboration and knowledge co-creation among all stakeholders in every phase of the project. By building on existing research, findings and available information as well as on existing guidelines and recommendations, we will 1) increase understanding of the determinants of low vaccine uptake in specific contexts situated in the EU and/or Associated countries; 2) develop strategies to increase vaccination rates within these contexts; and 3) develop a series of recommendations that national and regional public health authorities could implement in order to increase vaccine coverage. Through the interdisciplinary approach and strong involvement of end-users and relevant stakeholders, we will maximize RIVER-EU’s impact by making sure the guidelines will be readily implementable, thus reducing health inequalities and improving access to vaccination services among underserved communities and increasing vaccine uptake and coverage in Europe.

Keywords: vaccine uptake,children,adolescents,underserved communities,equity,health system research,tailor made interventions,participatory action research
Molecular Uptake Mechanisms controlling Plant Growth (MUM-GROW)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1999910.0
EU funding (EUR): 1999910.0
Participants: 1
Project status: SIGNED

Life on Earth is sustained by plants. Growth and development in the plant kingdom is mediated by the controlled distribution of sugars and the hormone auxin, but we still know surprisingly little about the molecular details of this essential part of fundamental plant metabolism. MUM-GROW will elucidate the molecular mechanism of sugar and auxin transmembrane transport in plants. It moves the frontiers of the field by shifting the focus to molecular studies in vitro allowing structural and biochemical experiments to be performed. Correct plant growth and development is completely dependent on sugar uptake in growth zones (the meristem), and made possible in all plants by sugar transporters called SUCs and STPs. Growth polarity is created by an asymmetrical gradient of auxin mediated by auxin transporters called PINs. Despite extensive research, the molecular mechanisms of SUC, STP and PIN transport remains unknown. If we knew the molecular determinants of their function, it would allow us to predict, augment and possibly modify plant responses to a changing environment. I will address this using a complementary set of methods founded in structural biology to determine the 3-dimensional structures of key players in these transmembrane transport systems. This will be combined with biochemical characterization to address important mechanistic questions and elucidate their molecular mechanism. Understanding the mechanisms that govern plasticity in growth is essential for determining resilience of whole ecosystems. This proposal will lead to a breakthrough in our understanding of sugar and auxin homeostasis, a fundamental part of basic plant metabolism. It has tremendous potential for the societal challenge to secure sufficient food for our global population in a sustainable balance between environmental impact and resource exploitation. Furthermore, this proposal will uncover general molecular principles of transmembrane uptake and export pertaining to all organisms.

Keywords: membrane proteins,crystallography,cryo em,sugar transport,hormone transport,plant growth,plant development
Using global marine metagenomics to understand MERcury microbial associated processes: finding a CURE for mercury contaminated environments (MER-CURE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-09-30
Duration (months): 25.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Millions of people are exposed to harmful levels of the potent neurotoxin mercury (Hg), concretely to the organic form methylmercury (MeHg) that bio-accumulates in organisms and biomagnifies in marine food webs. Understanding Hg transformations in the ocean is critical because commercial fish are mainly marine species. While it is well known that both MeHg formation and degradation are genetically mediated by prokaryotes, there are still sizable gaps in the fundamental understanding of the organisms and mechanisms involved in Hg transformations in the environment and therefore a clear lack of available techniques for Hg removal based on the action of these genes. MER-CURE aims at filling this gap by providing the first Hg reference gene catalogue at a global ocean scale and by quantifying the individual and/or combined effect of the activity of these genes in a pilot Hg removal system. MER-CURE develops a novel and multidisciplinary methodological approach by merging omics and Hg stable isotope tracer technologies for studying the biogeochemistry and detoxification of Hg. Concretely, the fellow will take advantage of the available sequenced metagenomes and metatranscriptomes and isolates from the Global Ocean Circunnavigation Expedition Malaspina. She will carry out laboratory conducted experiments to elucidate the capacity of different marine isolates to detoxify Hg-contaminated sediments. MER-CURE will contribute to advance knowledge by identifying “where” and “which” prokaryotes in the ocean are involved in Hg cycling and to produce readily applicable results that can in the future help municipality and private industries. MER-CURE is committed to knowledge sharing and to engage the public into the action. The incorporation of metagenomic and metatranscriptomics analyses in Dr. Bravo toolbox will lead the fellow to master a rather unique combination of chemistry, biology, experimental approaches, public engagement, and knowledge sharing and communication skills.

Keywords: mercury,prokaryotes,metagenomics,metatranscriptomics,deep ocean,malaspina,mercury removal
Connecting Thematic Networks as Knowledge Reservoirs: towards a European Agricultural Knowledge Innovation Open Source System (EURAKNOS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Coordination and support actions
Countries involved: Germany,Spain,Estonia,Sweden,Greece,Belgium,Hungary,Hungary,Belgium,France,France,United Kingdom,Denmark,United Kingdom
Call: Thematic networks compiling knowledge ready for practice (H2020-RUR-2018-1, 2018)
Start date: 2019-01-01
End date: 2021-03-31
Duration (months): 27.0
Total project cost (EUR): 2101286.25
EU funding (EUR): 2101286.25
Participants: 19
Project status: CLOSED

EURAKNOS will boost compiling of knowledge ready for practice by intensifying interaction between various agri-food or forestry networks thereby maximising outputs for practitioners. The focus of this proposal is on widening existing thematic network outputs in an interactive way, both content-wise and in terms of geographical coverage. Avoiding duplication with the existing networks, cross-fertilisation will be organised between them and among countries, regions and production systems. EURAKNOS will tackle the data management with a view to ensure sustainability of these knowledge networks and maximise their outputs for end-users. To this end, EURAKNOS will stimulate the exchange of existing approaches, methodologies and tools between the different thematic networks (and linked EIP operational groups and H2020 multi-actor projects where relevant) and search for a harmonised approach for setting up future thematic networks in order to maximise the impact on the practitioner, farmer and forester. This project will also explore the end users’ needs and possibilities of setting-up a European agricultural knowledge and innovation open source system that may connect all TNs.
Trials@Home: Center of Excellence – Remote Decentralised Clinical Trials (Trials@Home)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Austria,Germany,Germany,Germany,Israel,Spain,Belgium,Switzerland,Switzerland,Switzerland,Belgium,Sweden,Greece,Belgium,France,France,France,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Centre Of Excellence – Remote Decentralised Clinical Trials (H2020-JTI-IMI2-2018-14-two-stage, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 39148297.88
EU funding (EUR): 19036997.5
Participants: 33
Project status: SIGNED

Clinical trials increase in size, complexity and costs. This is fuelled with the need to demonstrate effects in more complex therapeutic areas, and to detect subgroups with different benefit and safety responses. Complexities, rigid clinical control, physical distance and (perceived) burden put patient engagement under pressure. (S)low recruitment and retention compromise efficiency, generalisability and validity of traditional, site-centred trials. Remote Decentralized Clinical Trials (RDCTs) and hybrid approaches address these challenges. RDCTs are an operational strategy for technology-enhanced clinical trials, which enable (semi-)continuous data collection and real-world evidence generation, increase patient recruitment and retention and decrease patient and investigator burden and costs. Trials brought to the home of patients. Paradigmatic changes in EU clinical trial design are required to fully benefit from the digital era. Yet, the feasibility of running RDCTs needs to be rigorously demonstrated together with guidance and support measures for their execution. Trials@Home brings together a very strong consortium and will reshape clinical trial design, conduct and operations, by analysing, developing and piloting standards, recommendations and tools to define and operationalize RDCTs. Trials@Home will design and run a pan-European RDCT pilot based on: a. best practices of trials with RDCT elements, b. assessment of latest technological tools, c. the regulatory and ethical framework and potential changes required to facilitate RDCTs and d. stakeholder perspectives on the change from classical RCTs to RDCTs with strong patient involvement. The results of these assessments and the pilot will drive the formulation and dissemination of recommendations and tools for the implementation of RDCTs in Europe with the ultimate goal to improve the speed, quality and efficiency of clinical trials, and improving patients’ access to innovative treatment strategies.

Keywords: remote clinical trials