Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dynamic Growth and Replication in Coacervate Protocells (DynaGrow)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Replication and division are two of the most fundamental properties of living systems. Without replication, Darwinian evolution would not be possible, and life could never have reached the degree of complexity we see today. However, exactly how mixtures of non-living molecules developed the ability to replicate and divide, remains one of the biggest mysteries in modern science. Various molecular replicators have been investigated previously, but they are all destined to become extinct by dilution, since they lack a surrounding compartment that divides spontaneously during replication. In this proposal, we aim at developing a new class of coacervate-based protocells that are capable of active growth and template-directed replication. The coacervates we propose here are condensed liquid droplets with a unique dual role: they act as a compartment that holds together and concentrates the template molecules and the building blocks, and they provide the right chemical environment for the replication reactions to take place at an appreciable rate. The coacervate-based protocells are composed of oligopeptides with low complexity sequences, inspired by the intrinsically disordered proteins found in membrane-free organelles inside cells. Active growth is achieved through fuel-driven reactions, either by elongation of existing peptides or by specific chemical modifications at the peptide side chains that enhance their coacervation potential. Longer peptides can also act as templates for conjugation of end-functionalized peptide fragments with sequence patterns complementary to the template. Protocells with sufficiently high growth or replication rates are not only stable against Ostwald ripening, but are also predicted to undergo spontaneous division through a shape instability. This would mark a key step in the emergence of minimal cells and open the way for the evolution of more complex life-like systems.

Keywords: protocells,self assembly,origin of life
Smart cuvette and portable Time-Resolved FRET for fast analysis of milk (I-Cuvette)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Italy,Italy
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

The aim of the I-Cuvette project is the development of a portable device based on biosensors capable of analytical quality to assess milk contamination at the first step of the collection logistics chain (farm,) with a favorable market price for the single analysis (comprising six target analytes: 5 different antibiotics in milk including: Beta-lactam, Quinolones, Tetracycline, Sulphonamide, Aminoglycoside; plus Aflatoxins). This will spare the transportation of contaminated milk. The I-Cuvette system may be used also at the delivery point of trucks collecting milk providing almost immediate results (10 minutes) and avoiding the need of laboratory confirmation tests in case of positive results. I-Cuvette will be developed by: - ISS BioSense (ISS) a new high-tech SME located in Naples, Italy created in 2008 whose mission is the use and the manipulation of molecules of biological origin to develop highly specific and sensitive sensors. - Kontor46 (K46) is an Italian private company established in Turin in 2012 and specialized in high-tech hardware and software developments, as well as in R&D services for the industry. In the dairy industry, milk contamination can happen at any stage of the production chain from the farm to the shelf. The conventional methods of analysis used for milk allow a thorough analysis with very sensitive Limits of Detection, but with the main disadvantages of requiring specialized staff, being time-consuming and expensive, finally, they need to be performed in a lab structure. The analytical performance of I-Cuvette, thanks to the use of biosensors, is better than the conventional methods used in the milk sector, with greater operational potential due to sensitivity, selectivity, reliability, portability, no sample pre-treatment, short time to results and low cost. In short, I-Cuvette combines analytical quality with short response time and cost similar to strips or other disposable fast tests.

Keywords: milk,biosensors,time resolved fret,food safety,antibiotics
Unprecedented spatial control of porosity and functionality in nanoporous membranes through 3D printing and microscopy for polymer writing (3D-FNPWriting)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-04-01
End date: 2024-12-31
Duration (months): 69.0
Total project cost (EUR): 1499844.0
EU funding (EUR): 1499844.0
Participants: 1
Project status: SIGNED

Membranes are key materials in our life. Nature offers high performance membranes relying on a parallel local regulation of nanopore structure, functional placement, membrane composition and architecture. Existing technological membranes are key materials in separation, recycling, sensing, energy conversion, being essential components for a sustainable future. But their performance is far away from their natural counterparts. One reason for this performance gap is the lack of 3D nanolocal control in membrane design. This applies to each individual nanopore but as well to the membrane architecture. This proposal aims to implement 3D printing (additive manufacturing, top down) and complex near-field and total internal reflection (TIR) high resolution microscopy induced polymer writing (bottom up) to nanolocally control in hierarchical nanoporous membranes spatially and independent of each other: porosity, pore functionalization, membrane architecture, composition. This disruptive technology platform will make accessible to date unachieved, highly accurate asymmetric nanopores and multifunctional, hierarchical membrane architecture/ composition and thus highly selective, directed, transport with tuneable rates. 3D-FNPWriting will demonstrate this for the increasing class of metal nanoparticle/ salt pollutants aiming for tuneable, selective, directed transport based monitoring and recycling instead of size-based filtration, accumulation into sewerage and distribution into nature. Specifically, the potential of this disruptive technology with respect to transport design will be demonstrated for a) a 3D-printed in-situ functionalized nanoporous fiber architecture and b) a printed, nanolocally near-field and TIR-microscopy polymer functionalized membrane representing a thin separation layer. This will open systematic understanding of nanolocal functional control on transport and new perspectives in water/ energy management for future smart industry/ homes.

Keywords: 3d nanolocal nanopore functionalization,high resolution microscopy induced polymer writing,membrane architecture printing,selective directed rate tunable transport,metal nanoparticle recycling
Effective field theories for non-equilibrium many-body systems (NonEqbSK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: SIGNED

Non-equilibrium phenomena continue to challenge our understanding of many-body systems appearing in nature. Macroscopic processes are generally irreversible due to dissipation. Reconciling this irreversibility with the unitarity of quantum mechanics has been one of the long-standing puzzles in physics. To date, we lack a systematic framework to account for stochastic thermal noise in many-body dynamics that becomes increasingly important as we leave equilibrium. The situation is particularly dire in systems that naturally operate far from equilibrium, such as fluids near a critical point, actively driven fluids, or fluids fluctuating in a confined volume, as the validity of existing models is limited. The goal of this proposal is to investigate these systems in the context of the newly developed Schwinger-Keldysh framework for non-equilibrium effective field theories. The new framework offers a systematic understanding of thermal fluctuations and dissipation starting from an action principle, and is suitable for constructing models describing non-equilibrium phenomena in many-body systems. During this fellowship, I will develop effective field theories specialised to the non-equilibrium systems mentioned above, and investigate their repercussions for observed phenomena. These results will have far-reaching impact in the fields of high-energy physics and condensed matter physics, especially concerning the hunt for the QCD critical point at heavy-ion colliders, modelling of living systems in biophysics, and biophysical membranes. This work will also provide insights into the broader physical problems such as the emergence of dissipation from microscopic principles and the quantum nature of gravity via the AdS/CFT correspondence. The increased visibility that I will gain in the scientific community due to these results, along with the training and experience I will obtain during this fellowship, will help me establish myself as an independent scientist in the future.

Keywords: schwinger keldysh,effective field theory,thermal field theory,stochastic models,critical phenomenon,hydrodynamics of active matter,casimir effect,relativistic hydrodynamics
European Researchers' Night in Sweden 2020: ForskarFredag (Researchers' Friday) 2020. (FF2020)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Sweden
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-05-01
End date: 2021-04-30
Duration (months): 12.0
Total project cost (EUR): 538755.5
EU funding (EUR): 120000.0
Participants: 1
Project status: CLOSED

ForskarFredag, FF will unite events in 26 cities and towns across Sweden. The project will bring the general public, with a special focus on pupils aged 12–19, face-to-face with researchers through fun, festive and hands-on activities, all free of charge. By reaching out to all across Sweden, people will discover local and regional research in a national and international context. The non-profit association Public & Science (VA) has coordinated FF annually since 2006, and FF2020 builds on the success of previous years, drawing on experience, contacts and the ever-increasing national profile. Local events will be planned and executed by local Subcontractors and External Partners in in centrally located venues and brought together under the national FF umbrella by VA. Subcontractors are 12 organisations; universities, science centres, a science park, a municipality and a research centre. Each local event is organised in a way to give the highest impact in the local community, building on local strengths and using local networks. The local organisers share experiences and learnings in a national contact network. VA is responsible for the quality, framework, national identity, national awareness campaign and impact assessment. This is a management structure that has worked well in the past years. The common theme, "Towards a Sustainable Future” focusing on climate, sustainability and environment, will inspire innovative local activities with the researcher in focus, connect the local activities and strengthen the national profile. Common activities include the high-profile communications contest Researchers’ Grand Prix. A Mass Experiment (national citizen science-project), inviting pupils to work together with researchers, will be conducted as part of the awareness campaign. Collaboration and synergies with other ERN projects will highlight the European dimension. ForskarFredag:s motto is: "Researchers are ordinary people with extraordinary

Keywords: national event,towards a sustainable future,research,science,hands on activities,general public,competition researchers grand prix,citizen science,collaboration with other ern projects
Brain injury and trauma monitoring using advanced photonics (BitMap)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Germany,Spain,Germany,Poland,France,United States,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 3835764.36
EU funding (EUR): 3835764.36
Participants: 13
Project status: CLOSED

Our vision is to develop a suite of standardised non-invasive devices that will provide essential information about brain health in neurocritical care and neuromonitoring, with a particular emphasis on 1. traumatic brain injury: the “silent epidemic of the third millennium” and 2. hypoxia in newborn children. Survivors present permanent neurological conditions that have a profound impact on the quality of life of individuals and their families, and hence a large socio-economic impact. The key factors influencing these conditions and their treatment are the avoidance of brain hypoxia and metabolic disturbances and this is driving the transfer of new neuromonitoring systems to the bedside where they are being shown to have a transformative effect on patient care. BitMap will develop non-invasive photonics-based monitoring techniques and data analysis methods to provide biomarkers that could guide patient management. A cohort of multi-disciplinary Early Stage Researchers (ESRs), embedded in leading laboratories across Europe, will work together on an programme designed to address the key technological and clinical challenges in neurocritical care. The ESRs will benefit from the diverse range of expertise in advanced photonics and clinical application which will substantially enhance their research competitiveness and employability, and will together form a critical mass of skilled people working together towards new technologies for improved neuroclinical care. The challenges involved are fundamentally multi-disciplinary and therefore ESRs trained in a multi-disciplinary environment are essential if progress and clinical impact is to be made. There is currently no graduate programme producing researchers with these attributes, but there is a significant market for such PhDs in the rapidly developing area of biomedical optics and in general in medical imaging technology development. The BitMap project therefore addresses both a clinical and economic need.

Keywords: near infrared spectroscopy,diffuse optical imaging,time resolved near infrared spectroscopy,diffuse correlation spectroscopy,traumatic brain injury,brain tissue oxygenation
Political Economy with Many Parties: Strategic Electorate and Strategic Candidates (PEMP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-08-01
End date: 2020-07-31
Duration (months): 60.0
Total project cost (EUR): 1499110.0
EU funding (EUR): 1499110.0
Participants: 1
Project status: CLOSED

Most real-life elections involve many candidates. Coordination problems in multicandidate elections make the strategic behavior of political agents fundamentally different than in two-candidate elections. The literature’s typical focus on two-candidate settings is thus a clear handicap to understand elections outside the US. The main objective of this project is two-fold: (i) generating new methodological tools to analyze the behavior of candidates and the electorate in multicandidate elections, and (ii) using those tools to generate new knowledge. These are crucial steps toward designing better political institutions. Component 1 focuses on the strategic behavior of voters. The objectives are: (i) to develop a more realistic model of strategic voting by including both strategic and non-strategic voters; (ii) to estimate the share of strategic and non-strategic voters in the electorate using laboratory experiments; (iii) to study voter behavior under relevant electoral rules, and their equilibrium properties. Component 2 focuses on campaign contributions. The methodological challenge is to develop a novel model that captures the coordination problems faced by contributors. Though this topic deserves study in and of itself, it is not the only rationale for this component. Given similarities between strategic voting and strategic contributing, I am convinced that innovations in modelling strategic voting could emerge. Component 3 jointly studies the behavior of the electorate and candidates. The methodological challenge is to develop a novel model sufficiently simple to be used in many institutional setups, but sufficiently sophisticated to capture the subtleties of the strategic interactions between candidates and the electorate, and within each group. I consider two different approaches that build on Components 1 and 2, respectively. I will use this model to study important political economy applications (e.g. income redistribution, lobbying, and media influence).

Keywords: political economy,multicandidate elections,strategic voting,strategic candidates,campaign contributions,laboratory experiments
Estonian Key Account Management Services (EST-KAM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Estonia,Estonia
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 129025.0
EU funding (EUR): 129025.0
Participants: 5
Project status: CLOSED

The objective of the project is to enhance the innovation management capacity of Estonian SMEs. The action is aimed at two kinds of SMEs - beneficiaries of the SME Instrument of Horizon and SMEs with significant innovation activities and a high potential for internationalisation. For beneficiaries of the SME Instrument, the service package (the Key Account Management service) consists of identifying weaknesses in the innovation capacities of the beneficiary; identifying suitable coaches (based on the assessment in the first step) to address the identified weaknesses and moderating the coach-client relationship; and accompanying the beneficiary through the SME Instrument project. The service packages outside the scope of the SME Instrument (the “Enhancing the innovation management capacity of SME's” service) consist of carrying out a diagnostic audit of the selected SMEs; and developing and implementing a tailored action plan to improve the SME’s capacity to manage innovation processes. Within the current action, the ESTINNO-NET consortium aims to provide the 7-day service packages to 53 SMEs.

Keywords: key account management,enhancing the innovation management capacity of smes
Innovative Method for Affordable Generation IN ocean Energy (IMAGINE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Italy,Norway,France,United Kingdom,Portugal
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2017-RES-RIA-TwoStage, 2017)
Start date: 2018-03-01
End date: 2021-11-30
Duration (months): 45.0
Total project cost (EUR): 3761205.0
EU funding (EUR): 3761205.0
Participants: 6
Project status: CLOSED

The IMAGINE “Innovative Method for Affordable Generation IN ocean Energy” project aims at developing the Electro-Mechanical Generator (EMG), an innovative Power-Take Off (PTO) concept for wave energy applications able to convert slow speed, reciprocating linear motion into electricity. The EMG is based on the integration of a recirculating ballscrew and a permanent magnet generator, an architecture that dramatically improves average efficiency (70-85% also when working outside design conditions), reliability (20 years MTBF) and affordability (CAPEX reduction by over 50%) compared to state-of-the-art PTOs. During the IMAGINE project, the EMG technology will be demonstrated through the fabrication of a 250 kW prototype and its testing on a HardWare-In-the-Loop (HWIL) bench. This will allow progressing its TRL from 3 to 5. A range of Wave Energy Converters (WECs) will be emulated on the HWIL bench and the performance of the EMG, under the action of a robust control system, will be measured and extensively assessed. Furthermore, a FMECA analysis and a subsequent accelerated life test will prove the reliability of the system. HWIL tests will allow reducing technological risk in power rating increase, providing an intermediate step between tank tests and sea trials that represents a critical transition for wave energy development. Finally, a techno-economical assessment of the EMG and a complete Business Plan for commercialization will be developed. Such activities will be carried out by an international consortium with multi-disciplinary skills in marine energy, led by a leading-manufacturing company as Umbra Cuscinetti S.p.A. The IMAGINE project is related to the topic “Developing the next generation technologies of renewable electricity and heating/cooling”, under the category “Ocean Energy: Development of advanced ocean energy subsystems: innovative power take-off systems and control strategies.

Keywords: ocean energy,wave energy converter wec,power take off pto systems,electro mechanical actuators emas,electro mechanical generator emg,ballscrew