Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
self-PoweRed cONductimeter for digiTalization of rapid mOlecular diagnostics (PRONTO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-06-01
End date: 2024-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Despite huge progress in prevention and treatment over the past century, infectious diseases still impose a great health burden. For this reason, lab-centralised immunoassays and nucleic acid tests that allow for specific pathogen identification with limits of detection reaching few copies per ml of sample are readily available and supported by both national and private health systems in the developed world. However, these tests are neither affordable nor accessible to patients in low- and medium-income countries. Fortunately, lateral flow antigen-based have proven to be a fast, reliable and affordable tool to detect a wide range of pathogens. However, such tests suffer from cross-reactivity with related bacterial or viral species and more importantly, they often require 10^5 pathogens per mL to yield a positive result. It becomes clear that there is a clinical and technological need to develop rapid tests that combines PCR sensitivity – able to detect one copy per mL - with LF affordability. PRONTO proposes a novel low cost, sustainable and self-powered readout system for nucleic acid detection based on conductimetry. The key component consists on a paper-based and single use self-powered conductimetric sensor developed during ERC Consolidator Grant SUPERCELL. The sensing approach is unique and minimalistic, as it breaks the classic paradigm sensor-electronics-battery as the sensor and the power source are merged into one element while making the detection system energetically autonomous. The simplicity of the approach will enable the deployment of highly sensitive and digital tests for infectious diseases at affordable prices and in a sustainable manner at a global scale.
EDV2209 – a Paradigm shift in the treatment of stroke. (EDVance)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-01-01
End date: 2024-10-31
Duration (months): 34.0
Total project cost (EUR): 4422831.25
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Despite tremendous research efforts and a large number of clinical trials focused on developing treatments for stroke, the field's current state remains dismal. There are, at present, no efficient treatments nor promising drug candidates for this lethal and disabling condition. A different perspective with a new approach is therefore desperately needed. Edvince's drug discovery and development is born out of founder and Professor Lars Edvinsson's extensive, fundamental and pioneering research of cerebral circulation, receptor regulation, stroke and migraines. Edvince is now ready to conduct the first clinical trial in 2022 with its innovative and disruptive lead drug EDV2209, an orphan drug for the treatment of brain ischemia associated with severe subarachnoid hemorrhage (SAH). The drug helps to keep the blood vessels in the brain open, allowing brain cells to receive oxygen and nutrients to prevent brain damage.

Keywords: stroke,clinical trials,subarachnoid hemorrhage
Scalable Learning for Reproducibility in High-Dimensional Biomedical Signal Processing: A Robust Data Science Framework (ScReeningData)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Data science has quickly expanded the boundaries of signal processing and statistical learning beyond their accustomed domains. Powerful and complex machine learning architectures have evolved to distinguish relevant information from randomness, artifacts and irrelevant data. However, existing learning frameworks lack computationally scalable, tractable, and robust methods for high-dimensional data. Consequently, discoveries, for example, in genomic data can be the result of coincidental findings that happen to reach statistical significance. As long as groundbreaking advances in biotechnology are not accompanied by appropriate learning frameworks, valuable efforts are spent on researching false positives. ScReeningData develops a coherent fast and scalable learning framework that jointly addresses the fundamental challenges of drastically reducing computational complexity, providing statistical and robustness guarantees, and quantifying reproducibility in large-scale and high-dimensional settings. An unprecedented approach is developed that builds upon very recent work of the PI. The underlying concept is to repeat randomized controlled experiments that use computer-generated fake variables as negative controls to trigger an early stopping of the learning algorithms, thereby mitigating the so-called curse of dimensionality. In contrast to existing methods, the proposed methods are completely tractable and scalable to ultra-high dimensions. The gains of developing advanced robust learning methods that are computed ultra-fast and with tight guarantees on the targeted rate of false positives are enormous. They lead to new reproducible discoveries that can be made with high statistical power. Due to the fundamental nature and the broad applicability of the proposed learning methods, the impacts of this project extend far beyond the considered biomedical signal processing use-cases, benefitting all scientific domains that analyze high-dimensional data.

Keywords: robust signal processing,biomedical signal processing,high dimensional statistical learning,robust data science
6G Ai-native integRated Ran-cOre netWorks (6GARROW)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: France,Germany,Finland,Italy
Call: International Collaboration – EU-ROK (HORIZON-JU-SNS-2024, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 3107180.06
EU funding (EUR): 2999947.0
Participants: 8
Project status: SIGNED

This SNS international project fosters collaboration between the European Union (EU) and the Republic of Korea (ROK). AI-native radio access networks and integrated device-network approaches represent a paradigm shift in the field of wireless communication, offering unprecedented opportunities for innovation and optimization. By leveraging artificial intelligence (AI) technologies at the heart of radio access networks (RAN) and integrating devices seamlessly into network architectures, we can unlock new levels of efficiency, flexibility, and performance. Traditional approaches to wireless communication are often limited by static configurations and manual interventions, leading to suboptimal resource utilization and scalability challenges. In contrast, AI-native RAN and integrated device-network approaches empower networks to adapt dynamically to changing conditions, optimize resource allocation in real-time, and autonomously respond to diverse user demands and environmental factors. This transformative approach not only enhances the user experience by delivering higher throughput, lower latency, and improved reliability but also lays the foundation for realizing a diverse range of innovative services, including spatio-temporal, critical, compute-AI, omnipresent IoT, immersive communications, and global broadband services. Moreover, by fostering interoperability and collaboration between devices and networks, these approaches pave the way for seamless connectivity across heterogeneous environments, driving innovation and fostering new business models in the era of 6G and beyond. The project builds on the foundations of established EU-Korea research collaboration including 5G-CHAMPION project that demonstrated 5G technology in the 2018 Winter Olympics in PyeongChan, PriMO-5G project that demonstrated end-to-end 5G system providing immersive video services for moving objects and 5G-ALLSTAR project that showcased smooth 5G terrestrial and satellite integration.

Keywords: integrated device network artificial intelligence radio access network core network ai native
The European Deforestation-free law intended and unintended effect on the agricultural commodities supply chain sustainability (SustainableCommodity)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

The research project “SustainableCommodities” studies the European Deforestation-free law (EUDR) intended and unintended effect on Agricultural Commodities (AC) Supply Chains (SC) social, economic and environmental sustainability, providing insight into related business opportunities and risks, and ultimately suggesting improvements and reinterpretations to the existing regulatory framework. To meet the growing AC demand more resources are required to increase production, such as land, labor force, technologies, logistics, transportation, storage, and production infrastructure. However, the AC production is also responsible for significant negative impacts on the environment and on the people and communities involved especially in developing countries,. In governing AC SC dynamics, the EU has taken a decisive step with the EUDR establishing that "any operator or trader who places these commodities on the EU market, or exports from it, must be able to prove that the products do not originate from recently deforested land." The aim of the project is to: i) Understand if the EUDR, is setting the stage for the de-commoditization of AC, its effect on social, economic, and environmental sustainability of SC’s. ii) Establish what characteristics should a certification have to ensure environmental, economic, and social sustainability of the SCs and identify what technologies are functional for this purpose. iii) Clarify the EUDR effect on global AC flows and predict any possible availability risk and product demand risk. Understand the effect of the global flow change on sustainability in the SC. iv) Evaluate whether and how a substantial rethinking of the AC SC in terms of production, transportation, and transformation strategies is required and if the interplay between regulators, multinational firms, and farmers needs to be redefined by different, regulatory strategies and rewarding mechanisms.

Keywords: supply chain sustainability,agriculture commodities,sustainability policies,certification,de commoditization,eudr,transnational agriculture regulation
Functional Measurements IN-THE-KIDNEY to Diagnose, Understand and Treat Renal Tubulopathies (IN-THE-KIDNEY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

BACKGROUND | Renal tubulopathies are a large group of genetic disorders that disturb the function of the kidney tubule. A major challenge for diagnostics and treatment of magnesium (Mg2+) wasting tubulopathies, is absence of functional cell models and tools to study the pathophysiology. Diagnostics of hereditary Mg2+ wasting tubulopathies based on genetic screening, rather than biological measurements of kidney processes. Therapy largely depends on oral supplements because therapeutics that target the cause of disease are not available. VISION | In my vision, better insights in the cellular functional processes in the kidney are the next essential step forward towards better diagnostics, pathophysiological understanding and development of therapy. Development of functional Mg2+ transport measurements and innovative use of patient-specific models is required to increase diagnostic yield and to develop therapy. AIMS AND APPROACH | In this project, I aim to develop a urine-based diagnostic approach using scRNA sequencing and extracellular vesicle proteomics to provide biological diagnosis of renal tubulopathies. Using urine-derived adult stem cells, I will perform the first ever functional studies of ion reabsorption in kidney organoids. This approach allows personalized analysis of the pathophysiology as well as patient-specific drug screenings. Lastly, I will be the first to apply intravital multiphoton imaging in mice to measure Mg2+ reabsorption in the kidney tubule. The combination of patient-derived organoids and mice models will be used to test novel therapeutics. IMPACT AND INNOVATION | IN-THE-KIDNEY establishes the novel concept of biological diagnostics for renal tubulopathies, develops for the first-time patient-derived tissue models for functional analysis and introduces intravital ion transport measurements in mice. The methodology and approaches in this project will result in the identification of novel therapeutics for Mg2+-wasting tubulopathies.

Keywords: magnesium,tubulopathies,distal convoluted tubule,hypomagnesemia,gitelman syndrome
Conflicts Over Conspiracy Theories (CONSPIRATIONS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Slovakia,Sweden
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-08-01
End date: 2028-07-31
Duration (months): 60.0
Total project cost (EUR): 1499946.0
EU funding (EUR): 1499946.0
Participants: 2
Project status: SIGNED

In recent years, conspiracy theories have become an important issue not only to the people who propagate them, but also to those who fear their consequences and design initiatives to push back against the ‘post-truth’ era. Perceived as a major threat to liberal democracies, they are increasingly subjected to state-led interventions. Also many NGOs are now dedicated to preventing and combating conspiracy theories. Clearly, conspiracy theories have become a highly polarizing topic. The objective of CONSPIRATIONS is to analyse this growing tension over conspiracy theories in Europe. The project proposes an innovative approach which moves beyond an exclusive focus on ‘truthers’ to examine the perspective of ‘truth defenders’ as well. This project will analyse conspiracy theory not as a standalone phenomenon, but instead as an outcome of the complicated relationship linking stakeholders who are both separated and connected by the conspiratorial divide. By expanding the scope of study from conspiracy theories to conflicts over conspiracy theories, CONSPIRATIONS will explore the possibility that the worlds of these actors are mutually constitutive. This approach goes beyond the question of who is wrong and what to do about it. Instead, it offers a deeper understanding of the conflicts themselves, which are clearly of urgent importance for contemporary Europe. That understanding in turn will provide better knowledge for tackling the damaging effects of the conspiratorial divide. An important premise of this proposal is that the answer lies not in addressing the content of the conspiracy theories themselves, but rather the kinds of conditions that give rise to them. The secondary goal is to understand how these conflicts are influenced by social contexts, and how they unfold across diverse European settings. The objectives of this project will be achieved through ethnographic case studies in Belgium, Bulgaria, Estonia, Germany, Poland, Sweden, and EU institutions.

Keywords: conspiracy theories,social anthropology
European partnership on accelerating farming systems transition – agroecology living labs and research infrastructures (AGROECOLOGY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: COFUND actions
Partnership: Accelerating Farming Systems Transitions (co-funded)
Countries involved: Germany,France,Austria,Belgium,Cyprus,Czechia,Denmark,Estonia,Finland,Greece,Hungary,Iceland,Ireland,Italy,Lithuania,Netherlands,Norway,Portugal,Romania,Serbia,Slovakia,Slovenia,Spain,Sweden,Türkiye,Switzerland
Call: European partnership on accelerating farming systems transition – agroecology living labs and research infrastructures (HORIZON-CL6-2023-FARM2FORK-01, 2023)
Start date: 2024-01-01
End date: 2030-12-31
Duration (months): 84.0
Total project cost (EUR): 120000000.01
EU funding (EUR): 60000000.0
Participants: 75
Project status: SIGNED

AGROECOLOGY, the European Partnership ‘Accelerating Farming Systems Transition: Agroecology Living Labs and Research Infrastructures’, is an ambitious, large-scale European research and innovation endeavour between the EC and 26 Member States (MS), Associated Countries (AC) and Third Countries. AGROECOLOGY will support an agriculture sector that is fit to meet the targets and challenges of climate change, biodiversity loss, food security and sovereignty, and the environment, while ensuring a profitable and attractive activity for farmers. Major change is needed to make the agriculture sector more sustainable, resilient and responsive to societal and policy demands. Agroecology builds on natural, biological interactions while using state-of-the-art science, technology and innovation based on farmers’ knowledge. It represents a promising approach with the potential to respond to challenges faced by the European agriculture sector and to meet its needs. Real-life testing and experimentation environments, living labs are an appropriate instrument to accelerate the agroecology transition. Research infrastructures will also contribute to making scientific knowledge on agroecology available for this transition. Together these instruments will allow for ambitious experimentation at different scales, merging science and practice, to provide science-based evidence on the effects of novel approaches and accelerate the agroecology transition. AGROECOLOGY will pool the resources of the EC and the states involved to fund high-level research generating appropriate knowledge and technologies aligned with the core themes described in the Strategic Research and Innovation Agenda, while also implementing a series of supporting activities to inform, consult, advise and involve different stakeholders to build capacities, raise awareness and manage and exchange the knowledge and data created.

Keywords: living labs,research infrastructures,transition,agri food,farmer
The Geometry of Higher Symmetries (GEOSYM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

Symmetry structures are key to organizing the complexity of physical systems. In systems described by quantum field theories (QFTs) symmetries group observables, classify phases, determine selection rules and give insight into strongly coupled dynamics. They are irreplaceable in the study of phenomena such as confinement or duality. Recently, the notion of ‘symmetry’ in quantum field theories was understood to admit a substantial generalization to higher categorical structures such as n-groups and non-invertible symmetries. These realize further non-perturbative data yielding new handles in the study of QFTs. The goal of this project is to analyze such symmetry structures in geometrically engineered QFTs. We initially focus on theories in 4d parametrized by spectral curves and/or special holonomy spaces and aim to geometrize the symmetry representations and fusion structures related to their higher symmetries, building on both past work of the researcher and supervisor. This approach, unlike recent field theoretic developments, does not rely on a Lagrangian description of the QFT and therefore offers insight into confining properties and phase structures of strongly coupled systems. The foremost research objective of this proposal lies in charting these structures for increasingly less supersymmetric theories, including theories with no supersymmetry. All current evidence suggests that such symmetry structures only depend on topological data of the spectral curves and special holonomy space which we aim to trace through supersymmetry breaking deformations. Further research objectives include the study of analogous symmetry structures for superconformal theories in 5d and 6d. Such theories are intrinsically strongly coupled and the geometric methods developed in 4d, guided by field theory, come into their own as there are now no weak-coupling limits to extrapolate from.

Keywords: quantum field theory,higher symmetries,geometric engineering,spectral curves,confinement,strongly coupled physics,non lagrangian physics