Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
COMPREHENSIVE CANCER INFRASTRUCTURES 4 EUROPE (CCI4EU)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Coordination and support actions
Countries involved: Belgium,Bulgaria,Greece,Cyprus,Lithuania,Slovakia,Italy,Moldova, Republic of,Croatia,Slovenia,Ukraine,Romania,Portugal,Sweden,Spain,Finland,Estonia,Netherlands,Denmark,Ireland,Germany,Austria,Norway,France,Czechia,Luxembourg,Poland,Hungary,Latvia,Malta
Call: Strengthening research capacities of Comprehensive Cancer Infrastructures (HORIZON-MISS-2022-CANCER-01, 2022)
Start date: 2023-05-01
End date: 2026-04-30
Duration (months): 36.0
Total project cost (EUR): 9984080.25
EU funding (EUR): 9984080.0
Participants: 55
Project status: SIGNED

Cancer is the second leading cause of death in Europe with an expected increase of about 25% by 2035. A wide and unacceptable variability in terms of access to research, innovation and quality care exists between and within countries. Possible solutions are an increase in knowledge by funding research, and a more equitable transfer of what we already know to everyone. Comprehensive Cancer Centers and Comprehensive Cancer Care Networks may be the core of CCIs that deliver quality care and provide resources to improve and integrate care, research and education. Data already available confirm that the level of "CCI maturity" in Member States is widely different, from some countries lacking CCIs completely. A European initiative, implemented in all Member States, based on a capacity building programme (CBP), will help reduce inequalities, in the context of other actions ongoing, such as CRANE, JANE and UNCAN. CBP is a complex intervention that requires multiple and integrated actions delivered to all the relevant stakeholders. CBP will be designed with an inclusive approach, tailored to the baseline status, capable of creating a change and improvement in research and care, with greater integration between them, supported by an education programme. It will operate at various levels: Individuals, Institutions and Systems. The CSA will implement the following steps: define CCI Maturity Model including quality indicators; profile the CCIs in each MS and a few ACs in terms of CCI presence and levels of maturity; design tailored CBP interventions, giving priority to MSs without any CCI; deliver online training courses open to teams in all MSs and ACs, implement targeted onsite interventions; scale up and sustain development; disseminate, exploit and report results. The CSA will maximize impact by bridging with the work of ongoing EU cancer research projects. National focal points will be key informants in making the links between the CSA, the EC and MSs.

Keywords: comprehensive cancer infrastructures,comprehensive cancer centres,capacity building,tailored interventions,team training,integrating research and care,maturity model inequalities
A European Health Data Toolbox for Enhancing Cardiology Data Interoperability, Reusability and Privacy (DataTools4Heart)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Türkiye,Greece,Netherlands,Romania,Czechia,Sweden,France,United Kingdom
Call: Innovative tools for use and re-use of health data (in particular of electronic health records and/or patient registries) (HORIZON-HLTH-2021-TOOL-06, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 7747906.25
EU funding (EUR): 7747905.0
Participants: 19
Project status: SIGNED

Cardiovascular disease (CVD) remains the main cause of mortality worldwide, accounting for about a third of annual deaths. Re-use of both structured and unstructured data has the potential for major health benefits for the population suffering from CVD. Healthcare data re-use in Europe faces privacy and fragmentation issues, a high diversity in data formats and languages, and a lack of technical and clinical interoperability. DataTools4Heart (DT4H) will tackle such challenges and develop a comprehensive, federated, privacy-preserving cardiology data toolbox. This will include, in an integrated platform, standardised data ingestion and harmonisation tools providing a common data model, multilingual natural language processing, federated machine learning, differentially private data synthesis generation, and 7 language models adapted to the cardiology domain. DT4H virtual assistants will help scientists and clinicians navigate through large-scale multi-source cardiology data. These tools will be: i) implemented ensuring privacy-by-design and thorough compliance with European regulations and data standards; ii) optimised as based on multi-stakeholder user-centred requirements; and, iii) validated in 7 clinical sites across Europe. DT4H will unlock currently inaccessible health data in unstructured data and allow multi-site federated data use. Together with its toolbox, DT4H will leave the legacy of a federated learning platform with an embedded metadata catalogue and AI virtual assistants, and the CardioSynth open database of synthetic data remaining as available for further research and AI experimentation. Effective use of the federated learning platform will improve enable improved AI diagnostic and treatment tools. Deployment of regulated solutions will extend existing healthcare management paradigms to reduce disease burden. Finally, DT4H tools, systems and methodology are highly generalised and will translate well to other clinical and research areas in medicine.

Keywords: cardiology health data toolbox,common data model,natural language processing,federated learning,virtual assistants,interoperability,synthetic data,artificial intelligence
Chiral Light Emitting Diodes based in Photonic Architectures (RADIANT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Spain,Sweden,Italy
Call: EIC Pathfinder Challenge: Responsible Electronics (HORIZON-EIC-2023-PATHFINDERCHALLENGES-01, 2023)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 3654473.29
EU funding (EUR): 3654473.29
Participants: 7
Project status: SIGNED

RADIANT (Chiral Light Emitting Diodes based in Photonic Architectures) is an innovative research endeavor with a transformative mission: the production of high-performing and cost-efficient chiral LEDs (light-emitting diodes) that harness the optical properties of scalable chiral metasurfaces, operating seamlessly across the visible to near-infrared spectrum. With a multifaceted approach, the project seeks to endow with chirality three distinct technologies: Organic Light Emitting Diodes (OLEDs), Perovskite LEDs (PeLEDs), and Quantum Dot LEDs (QdotLEDs), promising exceptionally bright output and remarkable degrees of circular polarization. These chiral LEDs find diverse applications in fields such as display technology, communications, sensing, and advanced lighting systems, promising to revolutionize various industries with their enhanced optical properties and broad spectral range. Leveraging the unique chiroptical response of chiral metasurfaces, RADIANT precisely modulates high Photoluminescence Quantum Yield (PLQY) emitters, including perovskite nanocrystals, quantum dots, and organic semiconductors, using advanced nanophotonic architectures that interact with light through optical resonances, thereby enhancing and modulating the light emission. At the core of the project lies a novel, scalable, and low carbon footprint soft nanoimprinting imprinting process that enables seamless integration of photonic nanostructures across different LED technologies in a broad spectral range. RADIANT unlocks the potential of nanophotonics for optoelectronic technologies through cost-effective and scalable chiral metasurfaces produced via soft nanoimprinting lithography while reducing the dependency on critical raw materials currently used in advanced LEDs. RADIANT promises to revolutionize the billionaire LED landscape market, combining technological innovation, economic viability, and environmental sustainability.

Keywords: quantum dot based leds,perovskite nanocrystals,organic semiconductor leds,chiral nanophotonic metasurfaces,nanoimprinting
Democratic Governance, Environmental and Climate Challenges, and Societal Transformation: Deliberation, Inclusiveness, and Citizen Empowerment for Sustainable Food Systems (DEMETRA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Estonia,France,Germany,Italy,United Kingdom,Sweden,Switzerland
Call: The climate imperative and its impact on democratic governance (HORIZON-CL2-2023-DEMOCRACY-01, 2023)
Start date: 2024-05-01
End date: 2027-10-31
Duration (months): 42.0
Total project cost (EUR): 2389322.5
EU funding (EUR): 2389322.5
Participants: 11
Project status: SIGNED

DEMETRA will demonstrate means to alleviate tensions between democratic governance and climate and sustainability transitions through an analysis of new deliberative participatory processes (DPPs) such as citizens’ assemblies and e-governance. These bottom-up processes can be highly inclusive allowing to afford a genuine political voice to all segments of society. Accordingly, gender and intersectional aspects (e.g., socioeconomic background, ethnicity) will be focused on throughout the project in particular with regard to citizen participation. DEMETRA analyzes the micro-, meso-, and macro-level opportunities for DPPs across Europe supporting the transition towards a more sustainable future; focuses in particular the transformation towards a more sustainable food system as a crucial case study; systematically compares DPPs’ setup, processes, and outcomes to identify best practices that contribute to citizens’ democratic engagement and the co-construction of sustainable societies; identifies DPPs that maximize inclusiveness and empowerment across social groups, particularly those at the margins of society; and identifies widely applicable solutions to engage in the transformation toward sustainable food systems. DEMETRA builds on a multidimensional approach that combines macro- (institutional), meso- (organizational), and micro-level (individual) explanatory factors; a cross-national comparative design that includes European countries with different DPPs experience and different food systems (Estonia, France, Germany, Italy, Sweden, Switzerland, and UK); and an integrated methodological approach based on multiple sources and methods (including population surveys, organizational survey, semi-structured interviews, participant observation, and public policy analysis). In view of the climate imperative and related environmental challenges, DEMETRA seeks to provide tools for a democratic governance of sustainability transformation.

Keywords: democratic governance,climate and sustainability transitions,deliberative participatory processes,citizen engagement,inclusiveness,empowerment
Paleo-Evolutionary Medicine: Using ancient DNA to study the origins of common complex diseases (PaleoEvoMed)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 1449315.0
EU funding (EUR): 1449315.0
Participants: 1
Project status: SIGNED

Common diseases, such as cancer, dementia and heart disease, are the leading causes of death globally. In the UK, it is estimated that 1 in 2 people will develop cancer in their lifetime, 1 in 3 will develop dementia, and 1 in 4 will die from cardiovascular disease. However, the risks of developing common diseases are not shared equally between individuals or populations. Genetic susceptibility to disease is a major contributor to disease prevalence, alongside diet, lifestyle and other environmental factors. Understanding the genetic component of disease risk is a critical issue in epidemiology, as it directly informs public health policy, disease prevention and the development of vaccines and novel therapeutics. Most of the existing research in this area has focused on the underlying genetics of risk, while relatively little is known about the evolutionary origins of common diseases. This is a major omission, as understanding the origins of genetic risk can improve health outcomes in the present. In this ERC Starting Grant, I will use ancient DNA to model the evolutionary origins of genetic susceptibility to the leading causes of death and ill health worldwide, including cancer, dementia, cardiovascular, metabolic, autoimmune, respiratory and infectious diseases. I will build and apply state-of-the-art computational tools to (i) model the effects of natural selection on disease risk in the human genome; to (ii) reconstruct the evolutionary history of human and zoonotic pathogens; and to (iii) model the effects of pathogens, and other environmental factors, on the evolution of human disease susceptibility.

Keywords: evolutionary medicine ancient dna complex traits polygenic adaptation infectious disease
Application of gas-phase atmospheric pressure ionization sources to assess the wide-scope determination of PFAS in environmental and biological samples (MS4PFAS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: SIGNED

Per- and Polyfluoroalkyl substances (PFAS) are undoubtedly a worldwide threat due to their high persistence and widespread distribution in the environment, bioaccumulation capacity, and toxic effect on human health through chronic exposure. Despite a lot of research has been conducted to find solutions for the "PFAS problem", critical gaps such as the lack of transparency of manufacturers, the analytical issues to determine PFAS, and the difficulties to find the best way to regulate them and minimize the environmental and human exposure remain the major challenges. Thus, it is important to develop an analytical platform not only to increase the reliability of PFAS determination but also to provide analytical tools to policymakers for a better application of in-force and future regulations. MS4PFAS aims to propose high-throughput cutting-edge methodologies based on mass spectrometry (MS) to sort out the complexity of the analysis of the vast families of PFAS. The use of novel and/or dual atmospheric pressure ionization techniques for non-targeted liquid chromatography-high-resolution mass spectrometry approaches will increase the range of ionizable substances and will lead to unprecedented advantages to achieve a wide-scope determination of ionic and neutral PFAS in biological and environmental matrices. The most promising analytical platform will be chosen to propose highly confident identification strategies that will be integrated into a powerful non-targeted workflow to address the determination of known and emerging PFAS. The workflow will be validated and used to extend the knowledge in relevant societal applications such as the monitoring of PFAS in drinking water, updating the development of more efficient water treatment technologies, and in human biofluids (breast milk, plasma, urine), upgrading running epidemiological studies on the links of chronic exposure to PFAS and observed health impairments.

Keywords: per and polyfluorinated alkyl substances pfas,high resolution mass spectrometry,gas phase atmospheric pressure ionization sources,non targeted analysis,water contamination,human biofluids
ReliablE in-Vehicle pErception and decisioN-making in complex environmenTal conditionS (EVENTS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Innovation actions
Partnership: CCAM (co-programmed)
Countries involved: Greece,Italy,Germany,Spain,Netherlands,France,United Kingdom,Poland
Call: More powerful and reliable on-board perception and decision-making technologies addressing complex environmental conditions (CCAM Partnership) (HORIZON-CL5-2021-D6-01, 2021)
Start date: 2022-09-01
End date: 2026-02-28
Duration (months): 42.0
Total project cost (EUR): 6812764.66
EU funding (EUR): 5534448.0
Participants: 14
Project status: SIGNED

Driving is a challenging task. In our everyday life as drivers, we are facing unexpected situations we need to handle in a safe and efficient way. The same is valid for Connected and Automated Vehicles (CAVs), which also need to handle these situations, to a certain extent, depending on their automation level. The higher the automation level is, the higher the expectations for the system to cope with these situations are. In the context of this project, these unexpected situations where the normal operation of the CAV is close to be disrupted (e.g. ODD limit is reached due to traffic changes, harsh weather/light conditions, imperfect data, sensor/communication failures, etc.), are called “events”. EVENTS is also the acronym of this project. Today, CAVs are facing several challenges (e.g. perception in complex urban environments, Vulnerable Road Users (VRUs) detection, perception in adverse weather and low visibility conditions) that should be overcome in order to be able to drive through these events in a safe and reliable way. Within our scope, and in order to cover a wide area of scenarios, these kinds of events are clustered under three main use cases: a) Interaction with VRUs, b) Non-Standard and Unstructured Road Conditions and c) Low Visibility and Adverse Weather Conditions. Our vision in EVENTS is to create a robust and self-resilient perception and decision-making system for AVs to manage different kind of “events” on the horizon. These events result in reaching the AV ODD limitations due to the dynamic changing road environment (VRUs, obstacles) and/or due to imperfect data (e.g. sensor and communication failures). The AV should continue and operate safely no matter what. When the system cannot handle the situation, an improved minimum risk manoeuvre should be put in place.

Keywords: perception,decision making,system self assessment,vulnerable road users,system integration,cost efficient sensor suites
Unravelling the Silicification prOcess in RHIzaria through GENetics and Skeletal growth (Si-ORHIGENS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2026-08-31
Duration (months): 46.0
Total project cost (EUR): 300441.6
EU funding (EUR): 300441.6
Participants: 2
Project status: SIGNED

Silicon (Si) is a major nutrient in the global ocean, required for growth by a variety of distantly related organisms, including microalgae, sponges and rhizarians. Silicifying Rhizaria were among the first protists to inhabit the ocean and, together with sponges, dominated the biogenic silica production during the Cambrian era. These organisms became an important, though poorly understood, component of marine ecosystems. In the contemporary ocean, diatoms are thought to dominate the planktonic realm and to be the main contributor to the Si cycle. However, my recent work has revealed that Rhizaria have unexpectedly high individual Si production rates and biogenic silica content, suggesting that their contribution to marine Si and carbon cycles may have been underestimated. This project aims to elucidate the process of silicification in Rhizaria and determine sources of variability in silicic acid uptake of these protists, through three tailored work packages (WPs). The first WP, consists of the analyse of transcriptomic data at a global scale as well as individual transcriptomes of isolated Rhizaria to assess the diversity of Si transporters. Thereafter, the examination of silica deposition, using a fluorescence compound, in a broad range of Rhizaria and varying ambient silicic acid concentrations. The final WP, will be the quantification of gene expression during silicification processes using primers designed within WP1. This highly interdisciplinary project combines bioinformatics, molecular biology and physiology, leading to a more unified approach to plankton research. The outcomes of this project will improve our general understanding of Si transport in Rhizaria as well as our understanding of the biogeochemical cycling of Si in the ocean. This work will also constitute a major advance in my career, as I acquire skills in new research methods beyond my current capacity, and build a unique skillset that will set me ahead of the current rhizarian research scope.

Keywords: marine silicon cycle,rhizaria,silicification