Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Market introduction of a revolutionary lab-on-a-chip Micro-Gas-Chromatograph for a cost-effective management of natural gas (PICOGC)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Germany,Italy
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-05-01
End date: 2020-02-29
Duration (months): 34.0
Total project cost (EUR): 2360762.5
EU funding (EUR): 1652533.75
Participants: 2
Project status: CLOSED

The Natural Gas industry is demanding for accurate and cost-efficient analytical technology to control internal processes along the whole supply chain. In particular, operators require analytical devices for gas chromatography able to ensure the strict safety and quality standards enforced by regulators. This industry is moving towards the use of MEMS (Micro-Electro-Mechanical Systems) for process control, as these microchips can integrate miniaturized laboratory functions using extremely small fluid volumes, thus increasing accuracy while reducing analysis time. Pollution, in collaboration with the Institute for Microelectronics and Microsystems (CNR-IMM), has developed a new MEMS for gas chromatography (MicroGC) which integrates a unique analytical MEMS-Column capable to obtain the best performances never achieved in the market. Our technology, named picoGC, with proven and measured advantages, is capable to face current limitations in MicroGC performances and manufacturing process. On the one hand, picoGC increases sensitivity (x 2) and linearity (x 3.5) in analysis compared to current MicroGC, being capable to preform standardized measurements in less time (1/2) and at a lower price (30-50%). On the other hand, picoGC manufacturing process will be more automated and compatible with current processing technologies. Pollution has partnered with Micronit GmbH for the future mass production of the microchips, which will be further integrated by Pollution and commercialised as a single and robust analytical device. During this project, Pollution, Micronit and CNR-IMM will integrate the tested analytical column into a complete MEMS-prototype and to validate the first batch of picoGC pre-series. Pollution will launch into the market a complete MEMS-based MicroGC range of analysers for natural gas analysis in 3 commercial applications: control of odorants, analysis of gas composition and measurement of the heating value of natural gas.

Keywords: mems,microgc,lab on a chip,natural gas,calorific power,mud logging
Progeria models to study endothelial cell ageing: implications for organ regeneration and fibrosis (EnCAge)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2020-02-01
End date: 2022-01-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Capillary endothelial cells (ECs) are not just passive conduits for delivering blood. Rather, ECs also play tissue-specific functions by providing highly specialized sets of angiocrine factors that control tissue homeostasis, regulate stem cell self-renewal, and guide organ regeneration without provoking fibrosis. However, it is not known whether tissue-specific instructive functions of ECs are lost during ageing. Moreover, the causal role of EC ageing in age-associated tissue dysfunction has not been directly studied so far. The use of aged mice to study age-related tissue alterations and to develop new drugs is not practical, since it is expensive, time consuming and does not allow for high throughput screenings. Thus, it is key to develop more convenient experimental systems that recapitulate the phenotype of aged cells. Hutchinson-Gilford progeria syndrome (HGPS) is a rare disease caused by progerin, a mutant form of the nuclear protein prelamin A that induces premature ageing. Remarkably, HGPS mimics many of the characteristics of human ageing, and progerin has also been detected at low levels in aged tissues of non-HGPS individuals. Thus, HGPS experimental models have proven to be very useful for the study of physiological ageing. This proposal will study age-dependent and tissue-specific alterations in ECs using a mouse model of HGPS. Furthermore, the candidate will use mice with EC-specific expression of progerin to assess the causal role of EC ageing in age-related impairment of organ regeneration, modelled by liver repair after injury. Finally, the applicant will develop an in vitro system to identify mechanisms through which progerin-induced EC ageing may elicit fibrotic responses that could compromise organ repair, and to test compounds to prevent or reverse the acquisition of an aged EC phenotype. These studies will open new potential therapeutic approaches to tackle age-related disorders, one of the most prominent health issues in European societies.

Keywords: hutchinson gilford progeria syndrome,microvascular endothelial cells,fibrosis,organ regeneration
The Multimedia Yasna International Image Interoperability Framework (MUYA-IIIF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: United Kingdom
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2020-11-01
End date: 2023-01-31
Duration (months): 27.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Images published on the Web are currently locked up in silos because institutions use different image delivery software on their networks, one that is usually tightly coupled with their custom metadata structures. This has led to isolated data silos that prevent information to be easily reused. The International Image Interoperability Framework (IIIF) solves this problem with a set of protocols or Application Programming Interfaces (API), for requests between computers to allow images and metadata held in different digital repositories to be accessed in a standardised format. The IIIF standard is now used by a growing number of major libraries and other institutions around the globe. However, it is not possible in IIIF to locate a particular text passage without searching the whole manuscript because there are no tools to create and search document structure (as opposed to textual annotations and commentaries, for which tools already exist). MUYA-IIIF will establish proof of concept of the idea, generated by the ERC-funded project The Multimedia Yasna (MUYA, AdG 694612, 2016–2021), to develop and implement a IIIF compliant tool for annotating textual structure (e.g. siglum, title, folio number, chapter, stanza, verse), associate the image with the structured transcription of the text it bears, and make such structure detectable within IIIF. This PoC will 1) enable “expert sourcing” via an open source platform to capture structural information in multiple manuscript witnesses; 2) represent structural information in a way that connects the intellectual structure of the object with the user’s viewing experience; 3) potentially use machine assisted segmentation in marking up the text to create structure; 4) connect the metadata, structural metadata, and TEI-XML transcripts with the images in a unified user experience; 5) use open source software built on open standards, to create a reusable seamless user experience that replaces a typically onerous process.

Keywords: manuscripts,digital annotation tools,iiif,software development
Bringing Digital Twins to the Edge for mass Industry 4.0 applications (Edge Twins HPC)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Spain,Spain
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-03, 2019)
Start date: 2020-06-01
End date: 2021-11-30
Duration (months): 18.0
Total project cost (EUR): 99875.0
EU funding (EUR): 99875.0
Participants: 3
Project status: CLOSED

Digital twins, along with the Internet of Things and Edge computing , are expected to play a decisive role in the next decade’s industrial markets (Industry 4.0) enabling dramatic improvements in complex systems design and operation. However, this technology has not been yet widely implemented, since it requires the collaboration of experts in multiple fields and costly computational tools. The EdgeTwins HPC project brings a different approach that will extend digital twins to new market segments and users (i.e. SMEs). It aims to develop an open-source software tool (builder) to produce digital twins that run on the Edge. That is, they are installed on the physical asset they represent, and operate in very constrained compute environments. This approach will enable a new breed of novel real-time applications, from autonomous vehicles to small devices. The main objective of this FET Innovation Launchpad project is to evaluate the business feasibility of an open-source Digital Twin builder software for Edge applications and develop and test a demonstrator (alpha) for one or more use cases identified in the market analysis. To do so, the participants will leverage on the high-performance computing software stemming of the ExaQute FET Proactive project. These assets will allow, using Reduced Order Modelling techniques, to model complex 4D simulations to later extract the essential features of the solution so that similar results can be obtained at a vastly reduced computational cost.

Keywords: digital twins,edge twins,reduced order models,industry 4 0,automation and control systems,scientific computing,simulation and modelling tools,advanced computing
The Reversible Variable Transmission – Visionary Transmission for unprecedented Fuel, CO2 and Cost Savings (RVT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Belgium
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

It is clear that the automotive market is in need of solutions which are more sustainable, simpler and cheaper than those we have today. This is a Blue Ocean opportunity for the Reversible Variable Transmission (RVT) which transmits power in a totally new way to offer engine driven vehicles including hybrids unprecedented fuel, CO2 and cost savings. With its novel patented design, this improved Continuous Variable Transmission is the first of its kind not suffering internal drill-slip. The RVT is the first transmission in the world that can keep the engine always on its lowest fuel consumption curve. It saves 21-26% fuel and CO2 compared to a 6-speed Automatic for cars and even 56% for buses if an extra RVT and flywheel is added, saving annually 60 tonnes CO2 and 22.000 L fuel or € 19.300 per bus. On top of that, it is light, compact, nearly 100% recyclable, with low maintenance and low cost. The RVT is the result of extensive theoretical reasoning and years of engineering expertise from the inventor, also designer of Ferrari and McLaren’s DCT double clutch system, pump and hydraulics. As no one else masters this know-how, Mazaro is the most capable to bring the RVT to full commercial success. To do this, it will attract new investors, grow as an engineering company to a team of fifty by 2021 and strengthen its partnerships with industrial manufacturers. SME PHASE 1 will validate our intended strategy to demonstrate the system’s uniqueness and prepare it for market uptake; objectives which will be implemented in PHASE 2. The RVT is suitable for vehicles ranging from cars to heavy duty trucks. On that vast market, the RVT will be an unrivalled offering to society, end-users and all companies involved. It is to be noted that Mazaro received Frost & Sullivan innovation award (visionary innovation leadership award 2015) for the reversible variable transmission.

Keywords: transmission,reversible,continuous,single speed,gearless,continuously variable transmission,fuel efficiency,co2 emissions,motor,automotive,transport
Deciphering the role of adult neurogenesis in hippocampal memory codes by optically imaging neuronal activity in freely behaving mice (NeurogenesisCode)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Israel
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-10-31
Duration (months): 66.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

The hippocampal dentate gyrus (DG) is one of the few areas in the adult mammalian brain that exhibits neurogenesis, the continuous generation of new neurons. Much evidence indicates that adult neurogenesis contributes to hippocampal-dependent cognition, but the nature of this contribution remains elusive. I envisioned that the clearest path towards understanding the function of adult neurogenesis would be to reveal the changes that occur in the coding properties of DG neurons throughout their development, and the changes that these neurons impose on neural codes generated by the hippocampus. The study of such coding dynamics requires longitudinal recordings of neuronal ensembles in both the DG and CA1 over periods of weeks, since this is the timescale on which new DG neurons mature. Until recently, however, it has been technically impossible to obtain such data. This urgent need drove me to develop a new method, which allows for the optical recording of Ca2+ dynamics from up to 1,200 of the same genetically defined neurons in the hippocampus of freely behaving mice for periods of months. Here, I propose to combine this method with established tools for manipulation of neurogenesis rates or newborn neuron activity, to determine how neurogenesis contributes to coding dynamics in downstream CA1 while mice repeatedly explore familiar environments or preform a long-term memory task. Furthermore, we will establish time-lapse imaging of Ca2+ dynamics in populations of newborn DG neurons while mice perform tasks that engage the DG, and find how newborn neuron coding properties evolve as a function of their maturation. Our work will advance the understanding of how the hippocampus supports long-term memory by resolving fundamental questions that pertain to a nearly unexplored facet of memory: how memory codes change with time, while their behavioral manifestations persist.

Keywords: adult neurogenesis,hippocampus,dentate gyrus,place cells,neuronal ensembles,ca2 imaging,population coding,long term memory,representation of space
Climate and Weather in Indo-European (IE CLIMATE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-10-03
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: SIGNED

"Climate and Weather in Indo-European" (IE CLIMATE) is a research project which investigates the weather- and climate-related vocabulary of the Proto-Indo-European (PIE) language from a linguistic and cultural standpoint, with the goal of identifying the weather phenomena and climate conditions the speakers of PIE were exposed to and were familiar with, and of better understanding these early speakers' attitudes towards and interactions with the weather and climate of the areas in which they lived. I will attain these goals by: 1) collecting and analysing the Indo-European stock of climate and weather vocabulary in order to reconstruct the PIE words for these terms, ascertain the dates and locations of first attestation, and extrapolate from these the weather conditions of the Indo-European homeland; 2) collecting and analysing Indo-European religious formulae related to the weather, names and epithets for gods associated with weather and climate phenomena, and other relevant cultural material, in order to gain familiarity with and draw conclusions about the way the ancient Indo-Europeans lived with and understood their environment; 3) creating an interactive atlas of Indo-European climate and weather terminology. This aspect of the project involves correlating climate-related terms to the location and time at which they are first attested, in order to assess the origins and spread of climate terminology. IE CLIMATE will substantially increase our understanding of the physical world inhabited by the Indo-Europeans and the vocabulary they used to describe it. This project will also significantly add to the body of knowledge in the developing subdiscipline of Indo-European archaeo-linguistics (the integration of historical linguistics and archaeological methodologies in order to understand the material and social culture of the ancient unwritten past).

Keywords: indo european,historical linguistics,homeland,etymology,prehistory
The development, evaluation and commercialisation of an early years test of colour vision deficiency. (COLOURTEST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom,United Kingdom
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-12-01
End date: 2018-05-31
Duration (months): 18.0
Total project cost (EUR): 149645.0
EU funding (EUR): 149645.0
Participants: 2
Project status: CLOSED

Colour vision deficiency (CVD) is a genetic disorder of colour vision that affects 7.4% of European males and 0.4% of European females. Although there are reliable tests for diagnosing CVD in adults and older children, there are only a few tests for young children, and fundamental issues with these tests render them unreliable. For example, colours used in the tests are too similar for young children to discriminate given their immature colour vision, tasks are too difficult for them to complete, tests either over- or under-diagnose CVD, or are not widely accessible. Therefore, the current situation is that CVD can be reliably diagnosed only from about 5 years onwards. Earlier diagnosis would enable steps to be taken to ensure CVD children are not disadvantaged in early years education that relies on colour coded schemes and materials. Our goal is to develop, evaluate and bring to market an age-appropriate early years test for CVD. Our research on the ERC funded ‘CATEGORIES’ project is investigating the development of colour perception in over 1400 infants and toddlers. This extensive testing has given us specialist insight into the exact colours that are appropriate for an early years test for CVD. We have also developed age-appropriate tasks that measure young children’s responses to colour in a reliable and efficient manner. In the current project we propose to develop an early years CVD test in the form of an app. The test will use the colours that we have defined and the tasks that we have developed, and we aim for it to provide an accurate CVD diagnosis. The project will take the test to proof of concept and will establish the scientific validity, technical feasibility and commercialisation process. We aim that the test will be the ‘gold standard’ for educators, clinicians, scientists and parents. This will ensure that CVD can be detected earlier than is currently the case, bringing important and tangible benefits for education, clinical practice and research.

Keywords: colour,vision,child development
Understanding matter-antimatter asymmetries in B meson decays to three particles (DalitzCPviolation)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The search for sources of CP violation beyond the Standard Model is a high priority in contemporary particle physics. The violation of the CP symmetry is one of the necessary conditions to generate an asymmetry between matter and antimatter, as is observed in the Universe. The LHCb experiment has observed very large CP asymmetries in decays of B mesons to final states containing three charged particles. It is not yet clear whether these effects can be explained within the context of the Standard Model, or whether new dynamics are required. This proposal aims to address this challenge by bringing together the relevant experience and expertise of the researcher and the host institute. The decays of interest will be studied using the Dalitz plot analysis technique, which will allow to establish the dynamics causing the CP violation. The project requires the development and use of several novel approaches to the description of the decay amplitude, and will lead to significance advances in knowledge.

Keywords: beyond the standard model,cp violation,dalitz plot analysis