Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrated Process Control based on Distributed In-Situ Sensors into Raw Material and Energy Feedstock (DISIRE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Italy,Germany,Spain,Israel,Poland,Poland,Sweden,Sweden
Call: Integrated Process Control (H2020-SPIRE-2014, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 5998343.75
EU funding (EUR): 5998343.75
Participants: 15
Project status: CLOSED

The DISIRE project has been inspired by the real existing needs of multiple industrial sectors, including the world leading industrial partners in the non-ferrous, ferrous, chemical and steel industries that are highly connected and already affiliated with the SPIRE PPP and its objectives. The overall clear and measurable objective of the DISIRE project is to evolve the existing industrial processes by advancing the Sustainable Process Industry through an overall Resource and Energy efficiency by the technological breakthroughs and concepts of the DISIRE technological platform in the field of Industrial Process Control (IPC). With the DISIRE project the properties of the raw materials or product flows will be dramatically integrated by their transformation in a unique inline measuring system that will extend the level of knowledge and awareness of the internal dynamics of the undergoing processes taking place during transformation or integration of raw materials in the next levels of production. In this approach, the Integrated Process Control system, instead of having external experts to tune the overall processes, based on the DISIRE concept will enable the self reconfiguration of all the production lines by the produced products itself. Specific DISIRE Process Analyzer Technology (PAT) will be able to define quality and performance requirements, that for the first time in the process industry will be able to be directly applied on the physical properties of the developed products and thus enabling the overall online and product specific reconfiguration of the control system. In this way, the whole production can be fully integrated in a holistic approach from the raw materials to the end product, allowing the multiple process reconfigurations and an optimal operation based on the product’s properties that can be generalized in a whole product production cycle being spanned in multiple cross-sectorial processes.

Keywords: integrated process control,on ine pat based ipc,in situ sensors,machine learning,statistical learning,spatial swarm sensing,optimization,industrial demonstration
Understanding Social-Ecological Systems: Coupling population and satellite remotely sensed environmental data to improve the evidence base for sustainable development (USES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-11-01
End date: 2018-02-13
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

In developing countries the majority of rural communities rely on natural resources and environmental products for food, fuel, building materials and medicines. Rapidly changing socioeconomic conditions can have important consequences for environmental resources and ecosystem services. Consequently, the pressure that natural resources experience from population growth is a significant barrier to sustainable human development. This research project will broaden the approach to sustainable development research by studying population-environment relationships using data with unrivalled spatial and temporal resolutions. The objectives of the research are to identify: (1) How satellite data can be used to estimate aspects of environmental resources and ecosystem services important for livelihoods; (2) the relationships between household poverty and remotely sensed environmental conditions? And are these relationships consistent at different time periods? and; (3) how changes in poverty relate to changes in environmental conditions and vice versa? To study these relationships household panel survey data and remotely sensed environmental data will be coupled using GIS and non-parametric Classification and Regression Trees (CART) and random forests models which can handle and represent meaningfully the complex, nonlinear relationships between poverty and environment. The project will contribute to the Horizon 2020 aim of furthering sustainability science by exploring how changes in society and the environment are linked and contribute to society beginning to think about interventions to managing environmental resources which could contribute to development and to understand the changes likely in environmental resources when development occurs. It will contribute to the Work Programme as the fellow will gain new skills and training in geospatial and computational ecology and become an EU leading specialist in a research field with a lot of growth potential.

Keywords: population environment research
International cooperation for the development of cost-efficient kesterite/c-Si thin film next generation tandem solar cells (INFINITE-CELL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,Spain,South Africa,Germany,Belarus,Moldova, Republic of,Norway,Lithuania,France,Morocco
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2017-11-01
End date: 2023-04-30
Duration (months): 66.0
Total project cost (EUR): 1318500.0
EU funding (EUR): 1318500.0
Participants: 14
Project status: SIGNED

Photovoltaic (PV) is recognized as one of the main renewable energy solutions for fulfilling the targets defined by the EU Energy Roadmap 2050 and the SET Plan. Most of the current commercial PV devices are formed by single junctions, and more complex device concepts allowing a significant increase in device efficiency (well beyond the theoretical limit in the 30%-33% range) are still mostly limited to expensive III-V technologies. INFINITE-CELL proposes extending the very high efficiency tandem device concepts to emerging thin film PV technologies with high potential for reduction of costs and avoiding the use of critical raw materials. Within this context, the aim is to establish and consolidate an International and Intersectoral Cooperation between 6 EC/AC Academic Institutions (IREC, SINTEF AS, CNRS, UAM, IAP-ASM, HZB), 2 European Companies (SUNGA, MET), and 4 non EC/AC Academic Institutions (MASCIR, BSUIR, UM5, UWC), for the development of cost-efficient photovoltaic tandem devices based in the combination of wide band-gap kesterite absorbers (Cu2Zn(Si,Ge,Sn)(S,Se)4) as top cell, and low cost c-Si thin film as bottom cell. Thanks to the combination of the know-how generated in previous and successful FP7 projects (PVICOKEST (269167) and EUROSUNMED (608593)), INFINITE-CELL targets to develop stacked and monolithically integrated kesterite/c-Si thin film devices with efficiencies of 15% and 20% respectively, using only fully sustainable materials and processes. This will be possible through de definition of a very impacting Research Plan and a very ambitious Plan of Secondments, where 293 PMs will be exchanged among the partners. The seconded researchers will be immersed in an International and Intersectoral environment for the development and improvement of their networking, scientific, writing, effective communication, and time management skills, warranting the consolidation of a high level scientific community in Advanced Tandem Solar Cell.

Keywords: kesterite,c si thin film,tandem devices,cost efficient solar cells
Tracking the cognitive basis of social communication across the life-span (CogSoCoAGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2021-02-28
Duration (months): 66.0
Total project cost (EUR): 1488028.0
EU funding (EUR): 1488028.0
Participants: 1
Project status: CLOSED

A vital part of successful everyday social interaction is the ability to infer information about others (e.g. their emotions, visual perspective, and language). Development of these social skills (termed Theory of Mind, ToM) has been linked to improvements in more general cognitive skills, called Executive Functions (EF). However, to date very little is known of how this link varies with advancing age, and no model exists to explain the relationship. Thus, the key aim of the proposed research is to systematically explore the cognitive basis of social communication and how this changes across the life-span. The research will address three complementary objectives: (1) to what degree can variations in ToM ability across the life-span be accounted for by changes in EF skills, (2) how do ToM ability and EF skill change over time in different age groups (using longitudinal methods, i.e. test-retest of the same participants), and (3) can ToM ability be enhanced through training specific EF skills, and how do these training effects differ across the life-span. Contrary to traditional studies of social communication, I will employ an interdisciplinary approach that links theory and practice from cognitive, social, developmental, and clinical (neuro)psychology to study the relationship between ToM and EF across a broad and dynamic age range (10 to 80+ yrs old). I will use cutting-edge combinations of techniques (eye-tracking and EEG) and paradigms, alongside sophisticated statistical methods to track the timecourse of social understanding, and model how it relates to EF and more general cognitive/social skills (eg. IQ, language) within and between individuals. This research will open up new horizons in ToM research by developing an intervention programme to enhance the quality of social communication in older adults (thus improving their mental health and well-being), which has the potential to be applied in other individuals with social communication deficits (eg. autism).

Keywords: theory of mind,executive functions,ageing,training and transfer,eye tracking and eeg,interdisciplinary
Unravelling life-history responses and underlying mechanisms to environmental stress in wild populations (META-STRESS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Finland
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2020-12-31
Duration (months): 69.0
Total project cost (EUR): 1494882.5
EU funding (EUR): 1494882.5
Participants: 1
Project status: CLOSED

Organisms in the wild are constantly challenged by environmental variation in e.g. resource quality. The goal of this project is to move beyond laboratory experiments to understand the mechanisms that allow organisms in the wild to cope with environmental stress. Understanding the responses and mechanisms operating in wild populations is critical for assessing the eco-evolutionary consequences of environmental stress. The large metapopulation of the Glanville fritillary butterfly gives me a unique opportunity to study processes operating from genes within individuals all the way to metapopulation-level dynamics. I will use individuals sampled from families from specific local populations with known ecological background (based on > 20 years of data) to experimentally test the influence of environmental stress on life-history variation. I will combine these experiments with simultaneous life-history assessments on the siblings remaining in the wild, thus effectively coupling laboratory and field-based studies. I will integrate the ecological studies with molecular approaches to unravel the significance of different mechanisms – candidate genes, epigenetic inheritance and intestinal microbial communities – potentially influencing individual responses to environmental challenges. I will focus on the influence of host plant quality as an environmental stressor, which is known to greatly influence life histories in many organisms, and which can be manipulated in the laboratory and assessed in the wild. The proposed research has potential for groundbreaking results in evolutionary ecology, as the results will increase our understanding of 1) how individual responses to unfavorable environmental conditions and the underlying mechanisms vary within and among local populations in a spatially and temporally heterogeneous environment, and 2) how the consequent life-history variation influences the ecological and microevolutionary dynamics of wild populations.

Keywords: life history,metapopulation,environmental stress,conservation
VISION-DMD - Phase 2 Clinical Trials of VBP15: An Innovative Steroid-like Intervention on Duchenne Muscular Dystrophy (VISION DMD)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: France,Czechia,Czechia,Netherlands,United States,Luxembourg,United Kingdom,United Kingdom
Call: New therapies for rare diseases (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2021-12-31
Duration (months): 72.0
Total project cost (EUR): 16858748.72
EU funding (EUR): 6000000.0
Participants: 10
Project status: CLOSED

VISION-DMD aims to advance clinical development of the orphan drug VBP15 as a new therapy to revolutionise care for all patients with Duchenne muscular dystrophy (DMD) by 2020, in line with IRDiRC goals. DMD is an incurable, rare muscle wasting disease; boys progressively weaken, lose ambulation and death occurs by early adulthood. Corticosteroids (CS) are widely recognised to increase muscle strength and delay disease progression but global acceptance as standard of care is very variable due to severe side effects. VBP15 is an innovative steroid-like drug designed to retain or better CS efficacy and improve membrane stabilization with reduced or no side effects. VBP15 will increase the therapeutic window to slow disease progression and improve quality of life and lifespan for all DMD patients. Building on positive preclinical and Phase 1 results funded by government grants and international patient groups and based on FDA and EMA advice, VISION-DMD proposes a Phase 2 registration directed clinical programme aimed at an affordable therapy: Phase 2a will study the safety and tolerability of ascending doses of VBP15 in ambulant DMD boys; Phase 2b will demonstrate the efficacy and safety of two doses of VBP15 in young ambulant DMD boys. Both studies will be followed by extension studies for long term safety and efficacy data collection leading to cumulative exposure of up to 2100 drug months. The project proposes the Time to Stand Test as a highly relevant and reliable primary endpoint. Innovative exploratory serum biomarkers and novel wide scale MRI techniques will be used to investigate the VBP15 pharmacodynamics and the effect on muscle cellular pathology. VBP15 will meet the unmet need for better treatment for DMD with widespread acceptance and potentially be used in combination with stratified therapies as they are developed. The Consortium links the leading networks TREAT-NMD and CINRG with ECRIN-ERIC, for trial delivery and regulatory undertakings in Europe/US

Keywords: duchenne muscular dystrophy,corticosteroids,vbp15 steriod like,biomarker panel,orphan drug,phase 2 clinical trials
Emergent Ethics of Drone Violence: Toward a Comprehensive Governance Framework (DRONETHICS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-07-01
End date: 2023-06-30
Duration (months): 60.0
Total project cost (EUR): 1359348.0
EU funding (EUR): 1359348.0
Participants: 1
Project status: SIGNED

The increasing use of armed, uninhabited aircraft (drones) is a serious political challenge with implications for security and justice worldwide. Drone technology is attracting high levels of investment, drones controlled remotely are becoming more numerous, and technological momentum toward drones controlled by artificial intelligence (AI) is building. Many human lives are at stake in this, so the violent use of drones continues to raise ethical questions. DRONETHICS will systematically address an urgent need to clarify the morality of ‘drone violence’, defined as violence involving a weapon system that is radically remote from its immediate user. Such remoteness is achieved through extreme physical distancing or the devolution of agency from humans to machines, so drone violence disrupts traditional expectations about war and a warrior’s exposure to risk. In turn, the disruptively innovative premise of this project is that such violence does not necessarily fall within the remit of the Just War framework according to which war is traditionally judged and governed. Moving beyond state-of-the-art Just War thinking, the project opens up an ethical inquiry into drone violence conceptualised as either war, law enforcement, interpersonal violence, or devolved (to AI) violence. An interdisciplinary research team, incorporating international relations, moral philosophy and computer science perspectives, will conduct rigorous analysis of documentary sources and engage closely with officials, drone operators, and roboticists. Through innovative exploration and application of alternative frameworks for governing violence, DRONETHICS will produce: the first integrated conceptual framework for explaining ethical concerns arising from current and potential forms of drone violence; concrete recommendations for policy-makers on how to manage this violence ethically; and a new normative vision for shaping the longer-term trajectory of drone violence for the good of all humanity.

Keywords: military,computer science,artificial intelligence
Vancomycin resistance regulation in the antibiotic-producers streptomycetes (Vanrestrep)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-01
End date: 2020-01-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Antimicrobial resistance is a critical health issue today. Important pathogens have become resistant to many or all available antibiotics and limited new antibiotics are in the pipeline. Vancomycin is used as a ‘last resort’ antibiotic treatment for many bacterial infections, but worryingly vancomycin resistance (VR) has spread to major hospital-acquired pathogens such as Enterococcus faecium and Staphylococcus aureus. Most pathogen VR gene clusters likely came from actinomycetes, the natural producers of glycopeptides and most other antibiotics of natural origin. Induction of VR in the model actinomycete Streptomyces coelicolor is highly influenced by nutritional conditions, in particular by the phosphate (Pi) concentration in the medium. My previous work has shown that VR in S. coelicolor is blocked with Pi concentrations above 0.2%; suggesting a key role of this nutrient in VR repression. Furthermore, I have isolated a mutant strain (SCO2594::aac(3)IV) lacking this Pi control over VR. This mutant has cell wall synthesis defects and up-regulates a putative small non-coding RNA (sRNA) located in the promoter region of the vanSR regulatory genes. This project aims to understand the mechanisms of Pi regulation of the S. coelicolor van cluster, and to expand this study to other nutrients that may also control VR. A main focus is on the role of sRNAs in the regulation, as they offer potential novel targets for future clinical exploitation such as “antisense RNA therapy”. The work also aims to understand the role of SCO2594 in VR and to identify new players involved in the process. The proposed project represents an excellent opportunity for the researcher to develop new skills whilst helping to ramp up the development of new antimicrobial platforms in the Salas lab.

Keywords: glycopeptides,vancomycin,antibiotic resistance,streptomyces,srna,cell wall,nutrient regulation,phosphate metabolism,transcriptional regulation