Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Scientific Discoveries and the Public Debate on ‘The Human Condition’ in Victorian Britain: An Analysis of Periodicals for Young Readers, 1847-1900 (SCIENCE IN MAGAZINES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2009-01-01
End date: 2010-12-31
Duration (months): 24.0
Total project cost (EUR): 170142.1
EU funding (EUR): 170142.1
Participants: 1
Project status: CLOSED

In Britain, from the middle of the nineteenth century on, scientific discoveries (e.g. anaesthesia) and theories (e.g. evolution theory) fundamentally changed the way humanity perceives of itself; science engendered a controversial cultural debate on ‘the human condition’ and on humanity’s position in nature (or ‘creation’) that is still on-going. On the basis of a large corpus of Victorian periodicals for young readers, the project will examine the treatment of natural and human sciences (i.e. biology, medicine, ethnology, anthropology) and the extent to which this treatment reflects and positions itself within this public debate. The project will not only contribute to our understanding of Victorian literature for young readers – particularly with regard to interrelations between scien-tific discourse and its ‘translation’ into fictional and non-fictional texts for lay readers –, but also, more generally, to our understanding of the interplay of scientific development and cultural, ethical and religious debates that started in the Victorian period but which are still current today (for example in the controversies around the creationist concept of ‘intelligent design’ as part of school curricula). The project will utilize quantitative and qualitative approaches (descriptive statistics, discourse analysis, text-sociology, cultural history) to chart sociological factors of text production and reception and their influence on the treatment of science and its ideological implications. The researcher will publish his findings in journal articles. As a further result, the project will create an on-line database indexing the treatment of science in periodicals which will make the material much more easily accessible for scholars in the fields of British literature and cultural studies, the history of science, cultural history or other disciplines.

Keywords: humanities,english literature,british studies,cultural studies,history of science,juvenile literature,cultural history
Integration of regulatory networks in Pseudomonas (PSEUDOTOX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-05-12
End date: 2011-09-11
Duration (months): 40.0
Total project cost (EUR): 182276.12
EU funding (EUR): 182276.12
Participants: 1
Project status: CLOSED

The competitiveness of Europe in the field of antibacterial discovery programs has been drastically compromised due to a serious drift of academic expertise on antibacterial discovery away from Europe’s to major USA Pharmaceutical companies where the multidisciplinary skills required for this work is available in single institutions. ERA is therefore at serious risk of becoming non-competitive with North America where there is critical mass and excellent training in this area. To regain the European leadership in this field there is an urge to generate a critical mass of scientific workforce with the required advanced multidisciplinary training. The research project will use Pseudomonas aeruginosa as a model bacterial human pathogen to investigate the integration of different key regulatory systems in the control of essential molecular mechanisms for virulence and survival during infection with a view to identify novel antibacterial targets within these regulatory networks. This type of project cannot be achieved with the expertise of a single institution but can be attained through establishment of this IEF fellowship for advance complementary multidisciplinary training where both the host institution and the visiting fellow will benefit from the exchange of expertise. This IEF project is highly complementary to the applicant’s existing research skills and her extensive knowledge on advanced technologies for the study of bacterial biofilms formation, protein interactions and microbial ecology will, in return, bring new expertise to the University of Nottingham. The topic has been freely chosen by the fellow in collaboration with the host institution with the aim to maximise his employability, competence diversification and life long learning as an independent researcher.

Keywords: health sciences,infections,microbiology,molecular biology,gene regulation,antimicrobial targets
Coordination of European Research on Emerging and Major Infectious Diseases of Livestock (EMIDA)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Coordination and support actions
Partnership: EMIDA (ERA-NET)
Countries involved: United Kingdom,France,Germany,Germany,Netherlands,Italy,Denmark,Czechia,Belgium,Finland,Ireland,Norway,Sweden,Switzerland,United Kingdom,Cyprus,Lithuania,Israel,Türkiye,Spain,Austria,United Kingdom
Call:  (FP7-ERANET-2007-RTD, 2007)
Start date: 2008-04-01
End date: 2011-12-31
Duration (months): 45.0
Total project cost (EUR): 1092514.0
EU funding (EUR): 997218.0
Participants: 29
Project status: CLOSED

The disease threats to the livestock industry have increased steadily over the past decades as a result of globalisation, evolving pathogens and climate change. Responding to animal disease threats relies heavily on science; research makes a significant contribution to the development of disease control policy and the translation of policy, and other drivers for improving animal health, into practical effect. Although the legislation that underpins policy for the control of statutory diseases is determined at the EU level, the research that supports policy development and implementation is primarily carried out at the national level and is largely uncoordinated as is the research on other major infectious diseases currently affecting livestock production. The aim of the Animal Health ERA-NET is to build on and accelerate the work of the SCAR CWG in developing a durable focused network of national research funders in Member and Associated States of the EU for the purpose of sharing information, coordinating activities and working towards a common research agenda and mutual research funding activities in the field of animal health. The scope of the project will include emerging and major infectious diseases of production animals, including fish and bees and including those conditions which pose a threat to human health but excluding food safety issues relating to livestock products and diseases of wildlife except where they act as reservoirs of infection for humans or production animals. The objectives of the ERA-NET will be delivered through the following four workpackages: WP1. Project coordination, management, communication and dissemination; WP2. Mapping and analysis of existing research and current needs and information on the commissioning and management of joint programmes; WP3. Develop, test, evaluate and refine instruments (Pilots) and WP4. Developing a strategic trans-national animal health research agenda.

Keywords: animal disease research coordination
Mathematical Interfaces for Epidemiology and Environment (MATINEE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2009-08-20
End date: 2010-10-19
Duration (months): 14.0
Total project cost (EUR): 225566.68
EU funding (EUR): 225566.68
Participants: 1
Project status: CLOSED

This proposal would bring a mathematical epidemiologist from the U.S. to the University of Lyon (France) to collaborate with researchers in the Biometry and Evolutionary Biology Laboratory in research on the nosocomial transmission of rotavirus in pediatric and other hospital wards. Because of inadequate sterilization and pathogen resistance to antibiotics, healthcare workers and hospital equipment act as vectors to spread these infections from one patient to another, causing thousands of deaths each year, especially among children under five years of age. This project proposes to develop and analyze a sequence of mathematical models describing the transmission dynamics, beginning with deterministic compartmental models which describe the average spread of infections at the hospital level and progressing to stochastic and network-based models which take into account individual variations in transmission within small populations such as wards, and the structure of infectious contacts that connects multiple wards through workers and equipment moving from one ward to another. The project also includes two methodological components: one which will compare epidemiological indices of infection transmission such as the basic reproductive number, to see which best capture the effects of contact structures (how potential infection events occur), and another which applies uncertainty and sensitivity analyses in order to derive a measure of confidence in the results. This interdisciplinary collaboration, broad both in the fields of expertise from which it draws and in the spectrum of modeling approaches it uses, aims to play an important role in the context of public health: by putting predictive tools at the disposal of the community of physicians, it aligns with the public health strategy of the European Community in improving the capability to respond to significant public health threats.

Keywords: nosocomial rotavirus infection mathematical model hospital workers patients children deterministic stochastic network epidemic contact structures public health interdisciplinary
Establishment of cortical polarity in the one-cell C. elegans embryo (GOEHRING - POLARITY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2009-07-01
End date: 2011-06-30
Duration (months): 24.0
Total project cost (EUR): 159828.87
EU funding (EUR): 159828.87
Participants: 1
Project status: CLOSED

Throughout biology, from a single-celled bacterium developing into a mother cell and endospore, to the differentiation of gut epithelium in higher eukaryotes and even the morphological changes required in the generation of neurons within the human brain, the ability of a cell to generate intrinsic asymmetry plays a crucial role in development. In higher eukaryotes, this ability to polarize requires the establishment within the cell cortex of domains, which acquire distinct molecular and functional identities. One of the best-studied examples of cortical polarity is the one-celled C.elegans embryo, which undergoes an asymmetric division critical for sequestering the germ cell lineage. Prior to cytokinesis, a complex of conserved polarity proteins (PAR-3, PAR-6 and atypical protein kinase C - aPKC) is segregated to the anterior half of the embryo, while at the same time, a posterior domain containing PAR-1 and PAR-2 forms in the complementary posterior region. While it is believed that mutual antagonism between these anterior and posterior polarity complexes is critical to the formation and maintenance of these domains, the mechanisms underlying this process are poorly resolved and no coherent model has been achieved. This proposal takes a multi-disciplinary approach in order to explore how specific kinetic properties of PAR proteins give rise to discrete and robust cortical domains. To this end I will a) Use confocal microscopy to measure in vivo protein dynamics including cortical diffusion and cortical exchange rates and to quantify boundary gradients; b) Analyze how these parameters are affected by depletion or mutation of specific PAR components, and c) Develop and test quantitative models for maintenance of discrete cortical domains.

Keywords: polarity,par,cortex,cortical domains,cell morphology,development,diffusion gradients
Application of Droplet-Based Microfluidics for the Screening of Supramolecular Catalysts (MICRODROPCAT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-07-01
End date: 2009-12-31
Duration (months): 18.0
Total project cost (EUR): 157733.2
EU funding (EUR): 157733.2
Participants: 1
Project status: CLOSED

In this project we propose to develop new methodologies to prepare and screen large libraries of homogeneous catalysts based on supramolecular (self-assembled) ligands using droplet-based microfluidics. Presently, the discovery and design of efficient homogeneous catalysts still relies on time intensive trial-and-error methodology. To overcome these limitations, a new paradigm shift for the discovery of effective ligands relies on the supramolecular self-assembly of libraries of ligand through reversible non-covalent interactions. This significantly increases the potential chemical space within which an optimal ligand set can be found. The full potential of this methodology is impeded by current synthesis and screening techniques which rely on macroscale (mL) trial for all the ligands sets and reaction conditions. One effective strategy to increase the rate at which reactions can be performed at is through extensive miniaturization of the reaction vessel. Recent advances in droplet-based microfluidics have enabled the effective screening of reaction conditions on a nano- to pico- liter scale. We thus propose to develop, in collaboration with a lab-on-a-chip research group, a modular droplet-based microfluidic device which will enable the generation, within a nanoliter droplet, of supramolecular catalyst made up of self-assembled ligands around a transition metal. These catalytic droplets will then be merged with a stream of reactants to form a nanoliter-size reaction size vessel which will enable the catalytic activity of the self-assembled catalyst to be evaluated. The intended outcome of this project is to greatly accelerate the speed at which an active catalyst can be identified at. This will have a broad impact on the chemical community for which screening methodologies have become an integral part of the discovery process (e.g. drug discovery).

Keywords: homogeneous catalysis,combinatorial chemistry,organometallic chemistry,chemical engineering,microfluidics,supramolecular catalysis
Avian flight: Integrating experiments with aerodynamic theory (AVIAN FLIGHT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2008-09-01
End date: 2010-08-31
Duration (months): 24.0
Total project cost (EUR): 169563.3
EU funding (EUR): 169563.3
Participants: 1
Project status: CLOSED

Here we propose a series of experiments on the energetics and aerodynamics of avian flight and migratory behavior, to be performed at Lund University. In Experiment 1, we will be examining the effects of turbulence on the energy use of migratory birds in order to better understand how atmospheric conditions affect migrants and what effects climate change may have on them. In Experiment 2, we will be quantifying both the energetic and aerodynamic costs of natural and simulated molt; molt is one of the most important life-history events in the avian annual cycle. Finally, in Experiment 3, we will be studying the energetics of Common Swifts (Apus Apus) during both foraging flight and aerial roosting, when they are thought to sleep on the wing. We will be using a combination of wind tunnel work and field observations, and will use our results to update theoretical models of avian flight behavior. In the end, we hope to make significant advances in our understanding of avian flight and migratory behavior as well as form trans-Atlantic friendships which will result in future scientific collaborations.

Keywords: natural sciences,avian flight,turbulence,molt,aerial roosting,wind tunnel,thrush nightingale,common swift
Large-area ordered arrays of semiconducting oxide nanowires as electrodes for nanostructured hybrid solar cells. (CAMBAR07)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-10-01
End date: 2010-09-30
Duration (months): 24.0
Total project cost (EUR): 169390.93
EU funding (EUR): 169390.93
Participants: 1
Project status: CLOSED

The target of the present project is to fabricate high efficiency nanostructured hybrid solar cells in which the exciton recombination is strongly avoided by interface nanoengineering. The cells will be made in three main steps. First, large-area, ordered Anodised Aluminium Oxide (AAO) templates will be fabricated electrochemically onto transparent conducting substrates. Order will be induced prior to the anodization of aluminium by pre-patternig using Focussed Ion Beam (FIB). In a second step, the ordered templates fabricated will be used for the synthesis of large-area arrays of aligned semiconducting oxide nanowires. The arrays will be synthesized by electrodeposition within the template pores and by later removal of the same. Finally, films of conducting organic materials will be deposited onto the nanowire arrays by classical methods such as spin-coating from solution or thermal evaporation. The structures and devices obtained after each of the steps will be thoroughly characterised and the final test device performance will be evaluated. There are many materials science issues which will be addressed for improving the efficiency of hybrid solar cells. In particular, reduction of recombination of photo-induced charges through control of arrangement and size of oxide nanostructured electrodes, understanding of charge transfer at inorganic/organic interface, and permeation of organic semiconductor into the oxide nanostructures.

Keywords: self-assembly,solar cells,nanostructuring,nanoengineering,eletrodeposition,aao templates,semiconducting oxides and organics,nanowires,functional materials,excitonic cells,renewable energy
Defining the transcription factors code directing sensory lineage diversification and connectivity (SENSORY NEURONS CODE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2009-02-02
End date: 2010-09-01
Duration (months): 19.0
Total project cost (EUR): 178454.93
EU funding (EUR): 178454.93
Participants: 1
Project status: CLOSED

How is the enormous cellular complexity that characterizes the vertebrate organism arising? Cell diversification depends on the coordinated deployment of multiple programs of cell commitment. One fundamental question is how a discrete number of transcriptional programs combine to produce different cell types. This research aims to address the principles of how cellular diversity is created in the sensory nervous system. Specific objectives: #1:Defining the role of Cux1/2 transcription factors in sensory neuron subtype specification. #2: Defining the role of Cux1/2 in the establishment of specific contacts in the CNS. #3: Identifying potential interactions between Cux and other transcription factors driving diversification. Methods: We propose multidisciplinary approaches including model systems and methods such as rapid assessment of gene function in the chick, peripheral neural stem cell cultures, biochemistry, advanced mouse genetics. Significance and contribution to community: Dysfunction of sensory neurons is associated with a number of diseases lacking adequate treatment (chronic pain, irritable bowel disease, gastro oesophageal reflux disease). This is due to a lack of knowledge in the molecular and functional properties of the subpopulations of sensory neurons. Understanding the molecular mechanisms controlling sensory neurons development is necessary to understand the ontogeny of diseases and may open for new strategies for treatment. Objectives of the action: My goal is to perform research at the international top level and to develop my skills to become a good research group leader. This Marie Curie Fellowship will be highly important for my future scientific carrier. It will allow me to diversify my competence methodologically, to gain new expert knowledge in sensory biology, and to further my career in one of the best neuroscience centers in Europe

Keywords: health sciences,sensory nervous system,developmental biology,transcription factors,mouse,chicken,cell fate specification,connectivity network.