Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
GN5-2 (GN5-2)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Other destinations
Action type: Research and Innovation actions
Countries involved: Netherlands,Austria,Serbia,Slovenia,Azerbaijan,Belgium,Bulgaria,Croatia,Czechia,Cyprus,Germany,Portugal,Italy,Georgia,Greece,Estonia,Ireland,Latvia,Israel,Lithuania,North Macedonia,Montenegro,Denmark,Poland,Spain,Moldova, Republic of,France,Luxembourg,Romania,Slovakia,Türkiye,Malta,Armenia,Ukraine,Albania,United Kingdom,Switzerland,Hungary
Call: SGA to the FPA for Research and Education Networks (2024) (HORIZON-INFRA-2024-GEANT-01-SGA, 2024)
Start date: 2025-01-01
End date: 2027-06-30
Duration (months): 30.0
Total project cost (EUR): 115314953.75
EU funding (EUR): 80000000.0
Participants: 40
Project status: SIGNED

Under GN5-FPA, GN5-2 continues delivering expanded, cost effective, secure and resilient connectivity for unconstrained capacity ahead of demand in the backbone network and NREN access in multiples of 100Gbps targeting Terabit/s connectivity where needed. GN5-2 will scale its digital service portfolio to changing environments, by prototyping, piloting and, where appropriate, procuring new online above-the-net services to enable researchers and students’ access to applications that support multidomain data-driven, evidence-based and effective collaboration across virtual research teams, worldwide. It will deliver pervasive, innovative and distributed trust and identity infrastructure and services taking into account Open Science and eIDAS, to achieve strategic positioning of T&I as a key enabler of research and education collaboration within Europe. GN5-2 will reinforce the network security and its operation in a federated approach, and foster collaborations to innovate and strengthen Europe’s sustainable connectivity with other world regions. GN5-2 will address Horizon Europe’s priorities in areas such as data security and access control, innovation, inclusion, and DNSH, and will expand NRENs' users beyond traditional scientific and research communities, enabling networking and access to the common European data spaces, and preparing non-traditional use of fiber: sensing technologies, Quantum, Time/Frequency distribution. GN5-2 will ensure access to the valued services required for Open Science, disseminate learning and training, and build community as well as align with EU policies and ongoing participation with standardisation bodies. GN5-2 can offer its distinctive services due to its human network of professionals, in a consortium with a deep understanding of evolving user requirements. Knowledge and experience are shared within this community, to constantly enhance quality and security of services indispensable to the ERA, instrumental to EU strategic autonomy

Keywords: unified,knowledge creation,connecting,empowering,innovation,learning,governance,research networking,multi domain networking,secure,trust,research infrastructure,data,community
Tackling fibrosis and inflammation in LAMA2-RD by in vivo modulation of a novel modifier gene (LAMA2-TFIMG)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 246785.83
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

Merosin-deficient congenital muscular dystrophy (LAMA2-RD) is caused by mutations in the LAMA2 gene, coding for the α2 subunit of laminin-211 (merosin). Typically, LAMA2-RD patients with absent merosin are clinically severe and unable to walk, while those producing a partially functional merosin are clinically milder. I identified a unique family in which the oldest of two affected siblings shows a novel and extremely mild phenotype despite the complete lack of merosin. This patient is still ambulant at 33 years with no respiratory insufficiency or cardiomyopathy. Notably, this patient carries the same LAMA2 loss-of-function mutation as the sibling who followed the typical severe disease course. Hypothesizing that genetic modifier(s) in the atypical patient mitigate the consequences of complete merosin deficiency via a novel mechanism, I isolated unique ultra-rare polymorphisms in genetic factors related to genes expressed in the atypical patient muscle but not in muscle of non-related LAMA2-RD patients, and I identified a novel candidate modifier controlling both fibrosis and inflammation (key drivers of LAMA2-RD pathogenesis). Given that this modifier is severely upregulated in the control LAMA2-RD patients but highly downregulated in the atypical patient, I will decrease its expression in the severely affected LAMA2-RD mouse model DyW/DyW by using the CRISPR-interference tool delivered by a single AAV9. I will then assess motor strength and endurance in treated mice. Finally, I will isolate highly affected muscles and sciatic nerve to characterize any molecular and morphological change occurring in these tissues upon modulating the modifier gene expression. I expect to observe functional improvement in LAMA2-RD animals, thus ameliorating their phenotype. The proposed project will elucidate novel mechanisms attenuating LAMA2-RD severity and will allow me to design new therapeutic approaches for this disorder for which, to date, there is no approved treatment.

Keywords: muscular dystrophy,modifier genes,crispri,gene therapy,lama2 rd
Shift2Sustain: Driving Behavioural Change in Mobility Towards Sustainability (Shift2Sustain)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Climate neutral and smart cities
Destination: Climate neutral and smart cities
Action type: Coordination and support actions
Countries involved: Portugal,Netherlands,United Kingdom,Italy,Belgium,Slovenia,Spain,Croatia,Poland,Türkiye,Bosnia and Herzegovina,Denmark
Call: Mobility Management Plans and Behavioural Change (HORIZON-MISS-2024-CIT-01, 2024)
Start date: 2025-11-01
End date: 2028-10-31
Duration (months): 36.0
Total project cost (EUR): 4999238.75
EU funding (EUR): 4999238.75
Participants: 17
Project status: SIGNED

Shift2Sustain aims to promote sustainable urban mobility by driving behavioural change through improved Mobility Management Plans (MMPs) and Measures (MMMs). To this aim, Shift2Sustain focuses on (1) generating a database of information on existing MMPs and MMMs to understand their impact, success factors, and challenges, (2) developing assessment methods based on environmental, economic and social KPIs, (3) testing innovative approaches to understanding MMMs uptake and implementation, using gamification, serious games and behavioural incentives, and (4) empowering stakeholders and guarantee knowledge transfer. These four aims will be achieved through comprehensive data collection on current MMPs and MMMs to identify best practices and obstacles, pilot testing in seven cities to evaluate the effectiveness of different sustainable mobility strategies, stakeholder engagement and co-creation, development of evidence-based recommendations, including digital tools and policy guidelines for urban mobility planning, and knowledge dissemination, via open-access platforms, training programs, and partnerships with local authorities. Shift2Sustain aligns with the EU Sustainable and Smart Mobility Strategy, supporting the transition to low-carbon and energy-efficient urban transport. The project contributes to the EU Cities' Mission by integrating technical solutions with behavioural insights. Additionally, its focus on stakeholder involvement, policy alignment, and innovative transport solutions ensures that results can be widely applied across European urban contexts.

Keywords: mobility management plans mobility management measures,shift in travelling behaviour,serious games
Mapping the Evidence for the WHO Classification of Tumours: a Living Evidence Gap Map by Tumour Type. (WCT EVI MAP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: Research and Innovation actions
Countries involved: France,Spain,Poland,Germany,United Kingdom,Singapore
Call: Data-driven decision-support tools for better health care delivery and policy-making with a focus on cancer (HORIZON-HLTH-2021-CARE-05, 2021)
Start date: 2022-07-01
End date: 2026-06-30
Duration (months): 48.0
Total project cost (EUR): 2768241.25
EU funding (EUR): 2768240.0
Participants: 9
Project status: SIGNED

The WHO Classification of Tumours (WCT) underpins cancer diagnosis, and hence treatment and care of cancer patients, as well as research into cancer epidemiology, prevention, diagnosis, and treatment. However, decisions for such a global reference tool are not always informed by the best available evidence, and risks of incorporating misinformation into the clinical decisions pathway exist. We aim to develop a tool that maps existing evidence, showing gaps, identifying pockets of low-level evidence, and synthesis of reliable evidence. The tool will map the evidence base of the WCT in order to facilitate evidence-based decision-making in pathology, and promote the application of higher research standards in the field. We will adapt the recently developed Evidence Gap Map (EGM) methodology, first time ever to be used in biomedicine. The resulting EGMs will increase the discoverability and use of studies by the WCT decision-makers, research commissioners, researchers and others. Our WCT-EVI-MAP project is organized in three subsequent phases, where we will apply a stepwise approach to: first, develop a framework and define evidence levels based on expert consensus; second, elaborate a series of Megamaps in iterative cycles describing evidence of all tumour types; third, perform a descriptive analysis of the use of evidence in a continuous updated exercise. To overcome identified challenges, several strategies are proposed, such as using recent advances in technologies, following a strict multidisciplinary approach and integrating this project into the WCT strategic planning for the 6th edition. We believe that the WCT EVI-MAP will represent a ground-breaking advance for the WCT and research in the field, and will accelerate progress in cancer diagnosis and management. Integration of evidence-based medicine methods has been shown to have a positive impact in other specialized medical fields and our project represents a first step towards an evidence-based pathology.

Keywords: who classification of tumours evidence gap maps evidence based decisions making
Multirotor Estimation of Wind (MEW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-17
End date: 2026-06-16
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: TERMINATED

In the last decade both remotely-piloted and autonomous multirotor aerial systems have been employed for a wide range of challenging tasks, including visual inspection and physical maintenance, that were previously either dangerous or impractical. Wide-spread adoption is, however, hindered by the sensitivity of existing systems to unpredictable disturbances caused by wind forces that they are not able to estimate and hence mitigate. With funding provided by Marie Skłodowska-Curie Actions programme, the MEW project seeks to use recently developed acoustic wind sensors in a sophisticated and mathematically sound estimation framework. Researchers will design entirely new algorithms for the estimation of wind forces so that they may be compensated for by the multirotor flight control system. Real-world tests and experiments will demonstrate the soundness of the research and lead to software implementations that are ready to be adopted by industry. The results of the MEW project will lead to a new wave of application domains for multirotor technology, and will create new approaches to estimating wind dynamics that may extend to other engineering and scientific questions around fluid dynamics.

Keywords: aerial robotics state estimation
The Congo-Ubangi watershed : An interdisciplinary approach to the genesis of a linguistic accretion zone in Central Africa (CongUbangi)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Central Africa’s Congo-Ubangi watershed spans multiple ecozones in the northern margins of the rainforest. It is a major hotbed of linguistic, cultural and human genetic diversity with deep occupation history. This linguistic accretion zone is home to a complex mosaic of genealogically and typologically diverse languages spoken by small-size communities with different societal organizations, material cultures, and subsistence specializations. Despite the myriad of new insights it could generate about language evolution and deep human past, it is poorly known due to difficulty of access and an astonishingly intricate configuration. The aim of CongUbangi is to understand the present-day interconnections between language, material cultures and genes in the Congo-Ubangi watershed and project them as far back into the past as possible through a holistic, localized and locally-enforced interdisciplinary approach. The project team’s core scientific expertise covers linguistics, ethnoarchaeology, and archaeology. Genetic and paleoenvironmental expertise is added through inter-university collaboration. CongUbangi will realize a breakthrough in our understanding of how linguistic diversity correlates with cultural and genetic diversity and why it originated and persisted in this specific ecoregion for millennia. New bodies of evidence from mutually-feeding disciplines will be integrated to determine whether (i) language shift is an adaptive strategy in response to environmental stress and (ii) past environmental changes impacted the synchronic distribution of linguistic enclaves. By untangling one of the most historically intricate areas of the continent, it will contribute to scores of theoretical and methodological issues in a large array of disciplines and blaze research trails in previously unimaginable directions. Beyond research, it will foster the preservation of small-scale autochthonous languages and cultures facing increasing extinction threats.

Keywords: linguistic diversity,language shift,language contact,niger congo,ubangi,central sudanic,ethnoarchaeology,archaeology,genetics,central african prehistory
Deciphering the Recognition, Recruitment and Modification of structured lncRNAs by the methyl-transferase complex METTL3/METTL14 and its cofactors (RRMs-lncRNA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-15
End date: 2026-05-14
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

The human METTL3/METTL14 methyltransferase complex (MTC) is responsible for the m6A methylation of a large set of RNAs, and plays a crucial role in tumorigenesis. It targets numerous long non-coding RNAs (lncRNAs), including Xist and MALAT1. To date, studies have only considered single-stranded RNA motifs, and a critical need for structural information on the complex in interaction with lncRNA has grown over the years. METTL3 and METTL14 form a heterodimer through their catalytic domains (MTDs). Additionally, each monomer comprises flexible regions that are essential to the complex activity but have been truncated because of their dynamics: the METTL3 tandem zinc-finger domains (ZFDs) and the RGG region of METTL14. Moreover, two cofactors of the MTC display a significant importance for its activity in vivo but have never been studied in interaction with lncRNA: the RNA Binding Motif protein 15 (RBM15) and the Zinc Finger CCCH-Type Containing 13 protein (ZC3H13). This project aims at understand how structured regions of lncRNAs are recognized by the functionally active MTC and its cofactors at an atomic level. For that purpose, we will measure the binding and methylation activity of both the ZFDs and RGG region to a set of RNA targets – corresponding to modified region of Xist and MALAT1 – in the context of the whole MTC with or without the cofactors. By using mutated and post-translationally modified protein, we will assess (i) the lncRNA binding cooperativity between ZFD and the MTD, (ii) the role of the RGG region methylation in lncRNA binding structure specificity, (iii) the role of the cofactors in lncRNA recognition. Finally, combining 13C methyl-TROSY experiments, segmental labeling, and paramagnetic relaxation enhancement, we will access the dynamics of the complex in interaction with the lncRNA in solution. We expect to bring high-impact structural information of the specific recognition, recruitment and modification of lncRNAs by the MTC.

Keywords: long non coding rna,methyltransferase,nmr spectroscopy
Nourishing Europe's Future through Regenerative Livestock Feed (NUTRIFEEDS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Germany,Denmark,Portugal,Spain,Switzerland,China,Greece,Lithuania,Finland,Italy,Poland,United Kingdom
Call: Animal nutritional requirements and nutritional value of feed under different production management conditions (HORIZON-CL6-2024-FARM2FORK-02, 2024)
Start date: 2025-09-01
End date: 2029-08-31
Duration (months): 48.0
Total project cost (EUR): 6812496.25
EU funding (EUR): 6812496.25
Participants: 15
Project status: SIGNED

NUTRIFEEDS is dedicated to developing regenerative animal feed solutions by transforming underutilised local plants and agri-food by-products into high-protein feed through cutting-edge, cross-disciplinary methods. Aligning with the EU's Farm2Fork strategy, the project aims to reduce the reliance on imported feeds, enhance agricultural circularity, and minimize waste. The initiative involves detailed analysis of raw materials, including net energy, followed by their enhancement through Black Soldier Fly larvae and targeted fermentation to improve nutrient content and reduce anti-nutritional factors. Experimental validation will contribute to enhanced diet formulation. The project explores the impacts on welfare, health, immune responses, microbiome, and behaviour of both monogastric animals and ruminants. Through collaborations with farms, experimental feeds from insect upcycling and fermentation will be refined. NUTRIFEEDS also seeks to build on existing silvopasture systems and engages farmers in co-creating local policies. It also integrates AI for insightful data analysis and development of software aiding farmers with efficient monitoring and feeding systems, allowing hence for the creation of feed formulations that enhance both animal health and welfare while sustaining productivity. Thus, the project emphasizes animal welfare, aims to reduce the environmental impact of feed production, and involves stakeholders in the development and dissemination of its solutions. Methods of preserving energy, such as drying powered by solar energy, will help to create extra revenue streams from the sale of feed. A proposed European Centre for Regenerative Animal Nutrition will facilitate dissemination and promote uptake of these innovations and will implement online courses based on NUTRIFEEDS findings. NUTRIFEEDS will factor in environmental, social and economic sustainability and will create guidelines to reinforce Europe's position as a leader in global innovation.

Keywords: drought and heat tolerant plants,targeted fermentation,side stream materials,animal health and welfare,productivity,sylvopastoral systems,on farm circularity,local feed,virtual european center
Formate-dependent Regulation of Cancer Metastasis (4M8)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Luxembourg
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Mechanisms underlying cancer metastasis are poorly understood and context dependent. An essential feature of disseminating cancer cells is metabolic plasticity which allows cellular adaptation to changing environmental conditions along the metastatic cascade. I discovered in 2016 the phenomenon of formate overflow, an alternative pathway for serine catabolism via folate-mediated one-carbon (1C) cycle. Instead of using formate for nucleotide synthesis (to support proliferation), formate overflow is characterised by formate excretion from cancer cells. Furthermore, I have convincingly demonstrated that mitochondrial 1C metabolism and increased extracellular formate concentrations promote cancer metastasis in a growth-independent manner. However, it remains unknown which intermediates of 1C metabolism contribute to this phenotype, how formate controls metastasis and how it can be targeted therapeutically. To cross the current edge of knowledge, I will (1) take advantage of genetic and newly developed analytical methods to dissect how the formate-dependent effects are propagated in cells; (2) describe intrinsic mechanisms to explain how the formate signal is relayed to promote metastasis and (3) exploit formate overflow for cancer cell killing by directly targeting the formate molecule. 4M8 will explain a novel concept of how a mitochondrial metabolic signal drives cancer cells towards a pro-metastatic phenotype and how this knowledge can be translated into a signature to analyse the metabolic state in human tumour samples. Finally, we will develop a novel tool to target formate directly within cancer cells. In sum, our research will shed light on an unexplored field of cancer metabolism providing the foundation to develop novel treatment approaches against metastatic cancer, the primary cause of cancer death.

Keywords: serine,one carbon metabolism,invasion,metastasis,13c metabolomics,formate,cancer metabolism,metabolic plasticity