Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
UpSurgeOn Academy: A multilevel educational platform for neurosurgical training. (UpSurgeOn Academy)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

UpSurgeOn is an Italian SME established in 2017, by Neurosurgeons for Neurosurgeons, with a focus on creating a educational platform composed by different educational apps, training and simulation devices actually in the Neurosurgical arena. We have 15 employees, including a combination of neurosurgeons, software developers, technicians and commercial people. Neurological diseases are a global healthcare priority as they include a wide category of conditions from head injuries, strokes, infections, dementia, Parkinson’s disease and even headaches. These conditions affect more than 1 billion people in the world irrespectively of age, sex or income and have estimate mortality rates of 6.8 million people a year. As of 2004 the economic burden of these diseases in Europe was estimated to be €139 billion, a number which has risen over the years due to higher incidence rates. Even though these diseases have such a large impact on the global population and the economy, access to appropriate care is very difficult for most people. In response to this challenge we have developed UpSurgeOn Academy, a series of educational apps, augmented reality simulator and anatomically accurate training devices with the objective of facilitating the learning curve for future neurosurgeons, decreasing time and cost of their studies. Our goal is to improve the accessibility of neurosurgical care worldwide, especially in less developed countries with fewer facilities by helping train more neurosurgeons. This solution will in turn boost the growth of our company, generating, by the fifth year after phase 2 execution, a turnover of €25.5 million, with €2.2 million in profits, 130 new people hired and a ROI of 2.67 per euro invested.

Keywords: neurosurgical training,application
NOTUS, SOLVING THE ACHILLES’ HEEL OF WIND POWER (NOTUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-09-01
End date: 2021-02-28
Duration (months): 30.0
Total project cost (EUR): 1996041.25
EU funding (EUR): 1397228.88
Participants: 1
Project status: CLOSED

The wind power industry is facing important economic losses due to premature failure of turbines, which leads to long downtime periods and costly O&M activities. That premature failure is frequently caused by damage in the blades coating, that cannot be detected with the standard quality control processes in the industry. das-Nano, aware of this problem, has developed NOTUS, the only inspection tool in the market with the capability of effectively detect internal damage in turbine coating. In this scenario, das-Nano has developed NOTUS, the first contact-less tool specifically designed for wind turbine inspection. NOTUS can perform deep characterization of individual coating layers of both metallic and dielectric materials, such as coating and paints in wind blades and aero structures. This includes detection of defects on individual layers, gaps between layers, surface erosion and surface roughness. Besides, NOTUS is the first tool in the market with the capability of quantifying inter-layer adherence, being able to anticipate possible defects and, therefore to prevent from downtime and blade changes in already installed turbines. The objective of the present project is the introduction of NOTUS in the main global reference markets of wind power energy.

Keywords: teraherzt,wind power,non destructutive tools,green energy,quality control,material inspection
Mechanical Immunoengineering for Enhanced T-cell Immunotherapy (MechanoIMM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-12-01
End date: 2023-11-30
Duration (months): 60.0
Total project cost (EUR): 1499800.0
EU funding (EUR): 1499800.0
Participants: 1
Project status: SIGNED

Cancer immunotherapy harnessing the power of a patient’s immune system to fight cancer is transforming the standard-of-care for cancer. Adoptive cell therapy (ACT), a potent immunotherapy that directly infuses a large number of tumour-reactive T cells into patients, has elicited dramatic clinical responses in leukaemia patients recently. However, solid tumour remains a major challenge as tumour employs a number of strategies to prevent effector T cells reaching the tumour sites and attacking cancer by generating a highly immunosuppressive microenvironment. Current strategies are focused on controlling the immune system or the microenvironment using biochemical immunomodulatory reagents to enhance T cell based immunotherapy. Approaches exploiting biophysical and mechanical cues for immunomodulation are largely underappreciated. In this proposal, we aim to exploit mechanical immunoengineering strategies through biophysical cues to develop novel immune related treatments to enhance the efficacy and safety of adoptive T cell therapy for cancer. We will first develop a mechano-training approach to promote the T cell infiltration into tumour tissues using engineered microfluidic system for controlled force application on T cells in a high through-put manner. Second, we will develop a mechano-responsive nanoparticle delivery system to selectively deliver T-cell-supporting drugs in tumour to overcome the immune suppression in the microenvironment and enhance T cell functions for killing cancer. Third, we will develop mechano-inducible cytokine-secreting T cell therapies to augment the efficacy and minimize the toxicity of ACT by exploiting and targeting the difference in tissue stiffness between tumour and healthy tissues. This proposed project will open a new horizon for immunoengineering through biomechanical modulation of immunity for enhanced cancer immunotherapy and provide insight into the fundamentals of mechanotransduction in immune system in health and disease.

Keywords: immunoengineering,cancer immunotherapy,mechanical modulation,adoptive t cell therapy,responsive biomaterials,force and stiffness responsiveness
Development of radical innovations to recover minerals and metals from seawater desalination brines (SEA4VALUE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Ukraine,Germany,Spain,Italy,Germany,Spain,Germany,Belgium,Finland,Switzerland,Netherlands
Call: New solutions for the sustainable production of raw materials (H2020-SC5-2019-2, 2019)
Start date: 2020-06-01
End date: 2024-05-31
Duration (months): 48.0
Total project cost (EUR): 6995736.25
EU funding (EUR): 6995736.25
Participants: 17
Project status: SIGNED

SEA4VALUE wants to deliver a Multi-mineral Modular Brine Mining Process (MMBMP) for the recovery of valuable metals and minerals from brines produced in sea-water desalination plants. The project will proof the feasibility of the next generation technologies (including advanced concentration and crystallization processes and highly selective separation processes) for recovery of Mg, B, Sc, In, V, Ga, Li, Rb, Mo and set the basis for their future assimilation in already existing SWDP and those yet to come. The EC and national public officials are well aware of the economic importance and supply risk of CRM and non-CRM, and are promoting new solutions for the recycling, exploration and mining of raw materials needs. SEA4VALUE puts together an industrially and user-driven consortium of 15 members that represent the whole value chain (from Water Infraestructure Operator to Processing Industry) who will extensively work during four years to proof that the measures presented are competitive, technically feasible, contribute towards circular economy strategies and sustainability goals. SEA4VALUE will upscale 10 technologies by developing novel selective membranes; producing new 3D printed selective adsorbents; applying advanced metallurgical solutions including solvometallurgy, ionic liquids and supported liquid membranes; improving membrane crystallization; and, developing thermally-conductive polymer composite materials for the heat exchangers to be used in multi-effect distillation while building confidence for the market uptake of the recovered elements, and therefore considerably reducing the arrival into the market and its uptake of brine as new source of raw materials.

Keywords: brines,dessalination plants,processing industry,value chain,eu dependency,raw materials,separation technologies,concenration and crystalisation,trace metals recovery,multi modular process
Discovering a novel allergen immunotherapy in house dust mite allergy tolerance research (MATCH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-01-01
End date: 2021-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The advances in medical sciences and biopharmaceutical development during the last decennia have been overwhelming. While the scientific and clinical insight in numerous diseases have significantly increased, the curative treatment to most diseases is still not in reach. The most common diseases such as cancer and chronic diseases are still challenging scientists. Therefore, during our ERC Advanced project the main goal was to develop a vaccine to cure cancer using targeted immunotherapy. We used dendritic cells (DCs) as potentiator to improve anti-tumor T cell activity. However, we discovered that many tumors display a high content of sialic acids which actively suppress DCs function and induce tolerance to tumor associated antigens. This unexpected serendipity finding that sialylation of tumor associated antigens induced tolerance to the body’s immune response opens a window of opportunity to use sialylation (modification with sialic acid) to induce tolerance in allergies, such as house dust mite allergy (HDM). In the ERC PoC project (MATCH) I will couple HDM major allergens to specific sialic acid using a linker molecule to induce immune tolerance towards effector T cells in inflammation processes during HDM allergy. The results will lead to validation of the technology developed during the ERC Advanced project and PoC that sialylation induces tolerance when used with HDM allergens. When PoC is reached, the MATCH technology will represent a new allergen immunotherapy in a vaccine technology for HDM allergy with shorter treatment protocols, better efficacy and reduced side effects can be developed. The future potential of this technology may be extended to other allergies and/or autoimmune diseases.

Keywords: allergies,house dust mites,sialylation,dentric cells,vaccine,allergen immunotherapy
The first affordable and easy-to-use IoT system that tracks pill intake with printed circuits technology (SIGUEMED)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

SIGUEMED is provides the first cost-effective and convenient solution to an unsolved world-wide problem of massive economic and societal impact: the non-adherence to medication of chronic poly-medicated patients. Low medical adherence represents a heavy burden for the EU28 in terms of: - Cost due to extra medical treatment that needs to be given and to additional hospitalisations: estimated at 125,000 M€/year. - Premature deaths that could be avoided with correct adherence to medication: over 200,00 citizens/year Currently there are several solutions that attempt to increase medication adherence, but none of them reaches a sufficient market penetration because they are not useful enough or do not fully meet user demands. To bridge that market gap, we have developed SIGUEMED. SIGUEMED is an IoT eHealth solution aimed at fostering and monitoring medical adherence in a disruptive way. By combining a smart personalized blister pack with printed circuits in its foil (key enabling technology), wearables connected via Bluetooth to the base dock and a SW platform, we are able to remind to the patients intake the time for the intake of pills, and to track if and when this intake has taken place. If there has been any breach in the intake, a cascade of alerts is sent to contact people (relatives, caretaker, pharmacists). Access to track records and monthly reports is also possible. SIGUEMED is especially user-friendly, even for digital immigrants. To commercialize SIGUEMED we will create a network of associated pharmacies, which will be our clients and will shape our network of authorized distributors. They will sale and provide SIGUEMED’s associate services to poly-medicated patients, which are the end-users. After five year of commercialization, we expect to have built a network of more than 10,000 pharmacies in 5 different EU countries and have reached more than 350,000 patients through them. The ROI of the project is of 3.80.

Keywords: medical adherence,polymedicated patients,ageing population,printed circuits,elderly,pharmacists,chronic diseases,pill intake verification,cascading alert,patients homecare,new business mode
Temporal Quantum Correlations (TempoQ)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-05-01
End date: 2021-10-31
Duration (months): 66.0
Total project cost (EUR): 1673875.0
EU funding (EUR): 1673875.0
Participants: 1
Project status: CLOSED

Correlations are central for our modern view on the foundations of quantum theory and applications like quantum information processing. So far, research concentrated on correlations between two or more particles. Indeed, for this situation it is well established that spatial quantum correlations are a useful resource for tasks like quantum cryptography and quantum metrology. There are, however, other types of correlations in quantum mechanics, which arise if a sequence of measurements on a single quantum system is made. These temporal quantum correlations have recently attracted attention, because they are central for the understanding of some differences between the quantum and the classical world. Moreover, due to experimental progress their observation has become feasible with trapped ions, polarized photons, or other quantum optical systems. This project aims at a full understanding and characterization of temporal quantum correlations. For that, we will derive criteria and measures for temporal quantum correlations and investigate their connection to information theory. Then, we will elucidate to which extent temporal correlations can be used to prove that a system is quantum and not classical. Finally, we consider implementations of temporal quantum correlations using continuous variable systems like nanomechanical oscillators and applications in quantum information processing.

Keywords: foundations of quantum mechanics,quantum information theory,quantum correlations
Recycling and Repurposing of Plastic Waste for Advanced 3D Printing Applications (Repair3D)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Spain,Spain,Italy,Belgium,Greece,Greece,Belgium,Greece,Greece,Belgium,France,United Kingdom,United Kingdom
Call: Smart plastic materials with intrinsic recycling properties by design (RIA) (H2020-NMBP-ST-IND-2018, 2018)
Start date: 2019-01-01
End date: 2023-05-31
Duration (months): 53.0
Total project cost (EUR): 5998832.5
EU funding (EUR): 5998832.5
Participants: 19
Project status: SIGNED

The project aims at the development of innovative reclamation and repurposing routes for end-of-life plastic and carbon fibre reinforced polymer (CFRP) components. This will be achieved by employing advanced nanotechnology solutions, Additive Manufacturing (AM) and recycled resources, for the production of high added value 3D printed products with advanced functionalities. In this way, the combination of AM, polymer processing and recycling technologies could constitute a new paradigm of a distributed recycling process, easily implemented at local scale in collaboration with the industrial sector and collection facilities, in order to create competitive, highly customisable products at lower production costs, in a flexible digital environment that fully unravels the potential of eco-design and allows for integration of smart intrinsic self-sensing, self-repairing and recycling options. The project aims to address all aspects and stages of thermoplastic and CF reinforced thermoplastic 3D printing material development from recycled resources, starting with the selection of suitable waste streams, strategies for material repair, compatibilization and upgrade towards AM processing, compatibility between different thermoplastic matrices and the reinforcing fibres and nanoparticles, comparative assessment of various AM thermoplastic processing technologies and closed-loop material optimisation in terms of processability and performance.

Keywords: additive manufacturing,carbon fibre reinforced thermoplastics,circular economy,thermoplastic recycling,cfrp recycling,design for recycling,recycling by design cfrps
Alternative Splicing Codes for Synaptic Specificity (SPLICECODE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2021-09-30
Duration (months): 60.0
Total project cost (EUR): 2496460.0
EU funding (EUR): 2496460.0
Participants: 1
Project status: CLOSED

Neuronal networks represent an impressive example of highly organized complex systems. Sperry postulated that selective neuronal connectivity is achieved by chemoaffinity labels. Several such labels for axon guidance and topographic mapping have been defined. However, until recently, molecules that direct the recognition of synaptic partners and functional specification of synapses have remained obscure. Chemoaffinity tags are envisioned to provide a recognition code that would encompass the recognition of self versus non-self, recognition of sister cells, and recognition of appropriate and inappropriate synaptic partners. Key parameters that determine the function of recognition systems are the diversity (number of independently recognizable tags), the repertoires of recognition tags in a cell population, and the contribution of tags to selective interactions. The finite number of protein-coding genes in the human genome severely limits the genetic resources that can be employed for generating molecular diversity. In this project we will test the hypothesis that alternative splicing is a central mechanism for the amplification of molecular diversity in recognition tags and their role in synaptic specificity. We will implement novel mass-spectrometry and sequencing methods to define molecular diversity of a highly diversified receptor family in mice. We will unravel the logic of receptor repertoires across cell populations and test the importance of cell type-specific alternative splicing programs for synaptic specificity. The focus of this project on cell-type specific alternative splicing advances a new dimension in neuronal transcriptomics. Discoveries and technical innovations made in this work should be applicable to molecular studies of recognition events in any system. Finally, human genetic studies link mutations in the gene families explored here to autism. Thus, insights from this work will facilitate analysis of the pathophysiology of this disorder.

Keywords: cell biological mechanism,synapse formation,cell adhesion,recognition