Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Elucidating the crosstalk between the immune system and brown adipose tissue in humans (IMMUNOBAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-05-01
End date: 2025-06-30
Duration (months): 38.0
Total project cost (EUR): 211948.4
EU funding (EUR): 211948.4
Participants: 1
Project status: CLOSED

Brown adipose tissue (BAT) is a promising therapeutic target to improve cardiometabolic health. However, BAT metabolism is dysfunctional in obesity. Hence, it is highly relevant to ascertain which mechanisms modulate BAT function and how it can be improved in this context. Mice studies indicate that the immune cells-brown adipocytes molecular interactions within BAT modulate its function. Indeed, mice knockout for the transcript Mecp2 in BAT macrophages show impaired BAT function and develop obesity. Further, cold acclimation activates specific subsets of infiltrated immune cells which improves BAT function. Altogether points to infiltrated immune cells as key players regulating BAT- but their identity and role, and if they can be targeted to activate BAT in humans, is unknown. The main questions we aim to tackle are: i) Which are the immune cell populations within human BAT? ii) Does local inflammation exist in BAT of obese subjects? Is it related to their disrupted BAT oxidative and metabolic capacity? iii) Is the BAT oxidative and metabolic capacity improvement, after a 3-month cold acclimation, driven by changes in BAT immune cell profile? To answer these questions, IMMUNOBAT will characterize the immune cell profile of BAT in lean and obese subjects, using novel single-cell omics in samples obtained by neck surgery. BAT oxidative and metabolic capacity will be assessed in vivo by state-of-art methods, combining the use of 15O-O2 and 15O-H2O - PET measures with in vitro mitochondrial respiration assays of brown adipocytes. These measures will be repeated in obese subjects after a 3-month cold acclimation (the most powerful stimulus to activate BAT). IMMUNOBAT will provide new mechanistic insights into obesity pathogenesis, at the same time that it expects to find new tools to improve cardiometabolic health by activating BAT. Further, it will promote the fellow´s training in adipose biology and immunology, and his growth as an independent and mature researcher

Keywords: brown adipose tissue,brown fat,brown adipocytes,browning,obesity,energy metabolism,cellular biology,immunology,inflammation,cold,cold acclimation,batokynes,secretome,mitochondria
Vibro-Acoustic Model Order Reduction (VAMOR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium,Sweden,France,Denmark,Germany,Italy,Ireland
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 2783606.4
EU funding (EUR): 2783606.4
Participants: 16
Project status: SIGNED

VAMOR contributes to a more sustainable and quieter future for Europe. Noise pollution has arisen as one of the key factors towards the degradation of the quality of life in European societies. Adding noise treatments commonly leads to an increase in mass and/or volume usage, harming the sustainability of the respective products, e.g. leading to heavier vehicles. To avoid such solutions and striving for the sustainability and optimal acoustic behaviour of products, vibro-acoustic design needs to be pushed earlier in their design phase. Additionally, product sustainability can be also enhanced by exploiting the information included in sound waves emitted during their operation, detecting potential malfunctions. In that context, efficient physics-based sound modelling is a key enabler towards not only optimized and sustainable acoustic profiles through efficient design procedures, but also affordable so-called digital twins that monitor product performance in real time. To this end, the overarching goal of VAMOR is to provide high level scientific and transferable skills training on a new generation of efficient vibro-acoustic modelling techniques, so-called model order reduction (MOR) strategies, to a group of high achieving, competent doctoral candidates to promote a quieter and more sustainable environment. This will be achieved by combining an excellent research programme with an exemplary interdisciplinary training programme. VAMOR brings together a remarkable consortium, which combines research leading academic institutions with a constantly innovating, wide variety of industrial partners working on software, material, testing, design and sound enhancement. By deploying such an inter-sectorial, multi-disciplinary consortium, VAMOR guarantees the creation of a coordinated research environment to develop and exploit novel tools for the efficient simulation of noise and vibration and promote sustainability and acoustic comfort of products.

Keywords: model order reduction vibration and acoustics numerical modelling digital twin machine learning finite element method boundary element method optimization
Combined Spatial-Temporal Models and Decadal Climate Predictions for Tuna Fisheries (CST-TUNA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 226751.04
EU funding (EUR): 226751.04
Participants: 1
Project status: SIGNED

Tuna, a cornerstone of global fisheries, representing 10% of marine catches and sustaining numerous jobs, confronts pressing challenges from overfishing and climate change. To address these issues comprehensively, our proposal outlines a three-fold strategy: 1 - Advanced Spatial Modeling: We will employ Bayesian spatial models, specifically INLA (Integrated Nested Laplace Approximation), to predict tuna catch and price dynamics while considering vital environmental factors. This approach will unveil intricate relationships between catch, prices, and environmental variables, providing a deeper understanding of the complex interplay; 2 - Climate-Based Predictions: Building upon the insights gained from our spatial models, we will integrate predictions from the Norwegian Climate Prediction Model (NorCPM). This integration will allow us to provide skillful forecasts for tuna catch and price fluctuations over the next decade. These forecasts are invaluable for anticipating and responding to dynamic changes in the tuna industry, enhancing its resilience; 3 - User-Friendly Web Application: In collaboration with experts from ICES (International Council for the Exploration of the Sea) and the Norwegian IMR (Institute of Marine Research), we will develop a user-friendly web application. By developing this tool, we aim to make our scientific insights accessible to a wide audience, including researchers, managers, and policymakers. This project not only enhances our understanding of tuna fisheries and climate vulnerabilities but also empowers coastal communities, supports sustainability, and aligns with the Sustainable Development Goals. Our commitment to open-science practices ensures lasting impact through readily available project code and results.

Keywords: spatial temporal models,bayesian,inla,numerical models,decadal prediction,tuna
Developing User-centred Approaches to Technological Innovation in Literary Translation (DUAL-T) (DUAL-T)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 2
Project status: CLOSED

Recent years have seen a growing research interest on the application of translation technology to literary translation workflows, mostly in the form of Machine Translation (MT) or post-editing of MT output. In these studies, literary translators' voices are virtually absent. This project will address the discrepancy between research in Computer Science/AI and Translation Studies, as well as the absence of literary translators from the conversation surrounding technological innovation in their profession. It will do so by proactively integrating literary translators' input in the co-creation of a new technology-inclusive workflow. Professional literary translators will be asked to perform literary translation tasks using (1) MT + post-editing, (2) a Computer-Aided Translation (CAT) tool environment, (3) a CAT tool environment with integrated MT. User testing will be performed using eye tracking, keystroke logging and screen capturing. In-depth interviews and focus groups will be conducted before and after the translation task to register changes in participants' attitudes towards technology before and after using it, as well as advantages and pain points of the tool employed. Being the first study of this kind in literary translation, results will help to (1) devise a technology-inclusive literary translation workflow employing a user-led approach, (2) assess whether and to what extent translation technology can enhance literary translators (particularly, the potential of CAT tools to work in combination with MT and/or as an alternative to MT-centric approaches will be assessed), and (3) mediate a dialogue between literary translators and translation technology developers by feeding back data on literary translators' use of and attitudes towards translation technology to the project's industry partner. It is expected that the project's findings will also contribute to the wider conversation around Human-Computer Interaction in other professions.

Keywords: translation technology,literary translation,translation,computer aided translation,social construction of technology,human computer interaction,user testing
Super Dryer – Breakthrough clean fibrer dryer to cut emissions in paper production, urban sludge and clothes recycling (SuperDryer)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Finland
Call: Green Deal innovations for the Economic Recovery (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-04-01
End date: 2024-12-31
Duration (months): 33.0
Total project cost (EUR): 3510000.0
EU funding (EUR): 2457000.0
Participants: 1
Project status: CLOSED

SuperDryer is a breakthrough clean fiber drying system to reduce energy use and GHG emissions in paper production, sludge processing and textile recycling. It will be the first fiber dryer to integrate renewable energy inputs, cutting GHGs to zero. It uses a patented closed-loop heat and moisture recapture system to recover 100% of heat, stop 100% of airborne emissions, and reduce energy use by 25% compared to existing dirty driers. TM Systems has 100+ experts developing innovative energy-saving equipment. Its installed technology already saves 1 nuclear power plant worth of energy annually. Initial customers will be pulp and paper mills and recyclers, with several interested buyers. Future customers will be municipal and industrial sludge processors, and textile recyclers. TM Systems has prototyped and validated SuperDryer. In this project it will pilot the first full-scale unit in a working paper mill and reach commercialization.

Keywords: environmental and green technologies,environmental protection
OPTIMISED, FABRICATION-AWARE METASURFACE DESIGN FOR STRUCTURED LIGHT CONTROL IN DIGITAL PATHOLOGY (OPTIPATH-HopOn)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Norway,Greece
Call: Hop-on facility (HORIZON-WIDERA-2025-03, 2025)
Duration (months): 22.0
Total project cost (EUR): 599375.0
EU funding (EUR): 599375.0
Participants: 2
Project status: CLOSED

OPTIPATH is pioneering a new paradigm in digital histopathology by enabling real-time, non-destructive, label-free, multidimensional optical imaging of tissue samples. Through the use of structured light, specifically vector vortex beams, and polarization- and spectral-resolved detection, the project aims to deliver a compact and adaptive platform for enhanced tissue characterization. At its core, OPTIPATH integrates advanced metasurfaces and MEMS technologies for light shaping, targeting major challenges in surgical and oncological diagnostics. The OPTIPATH-HopOn contribution brings to the consortium a fabrication-aware, simulation-driven design workflow for metasurfaces and photonic phase plates optimized for structured light generation. It introduces full-device electromagnetic modelling using the Wavesim platform, a high-accuracy, GPU-accelerated solver capable of simulating optical propagation through large, complex photonic structures. This capability will support a transition from trial-and-error empirical prototyping to predictive, scalable fabrication for tailored, inverse-designed components. The HopOn team will also develop a dedicated off-axis holography setup to quantitatively assess optical performance, establishing a closed loop between simulation, fabrication, and experimental validation. Alongside technical development, the HopOn action will assess the exploitation potential and intellectual property value of the design-to-fabrication pipeline, complementing OPTIPATH’s strategy. The HopOn partner, FORTH, is one of Europe’s leading multidisciplinary research centres. Its Institute of Electronic Structure and Laser brings world-class expertise in biophotonics, metasurface design, and photonic simulations. By joining OPTIPATH, FORTH enhances its role in biomedical optics, photonic design and metamaterials and integrates into a high-impact European research ecosystem, strengthening excellence, capacity building, and innovation in the Widening region.

Keywords: model based hardware design,fabrication aware simulation,photonics,wavesim,modified born series
Unravelling the impact of nucleosome arrays on condensin by implementing an in-vitro chromatin-loop extrusion assay (ConNuc)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 217965.12
EU funding (EUR): 217965.12
Participants: 1
Project status: SIGNED

The three-dimensional organization of chromosomal DNA is essential for critical genomic functions, including chromosome segregation, gene expression, and DNA damage repair. Structural Maintenance of Chromosomes (SMC) complexes, such as cohesin, the Smc5/6 complex, and condensin, are integral to preserving chromosomal architecture and supporting these vital processes. Condensin folds DNA into mitotic chromosomes through DNA loop extrusion, a process critical for proper chromosome segregation. Recent single-molecule studies using naked DNA as template have shed light on how condensin drives DNA loop extrusion through multiple dynamic DNA-protein contacts. However, in cells, DNA is organized into nucleosomes that further compact into chromatin fibers, stabilized by linker histone H1, which restricts DNA accessibility to most DNA-binding proteins. How condensin gets access to DNA and extrudes DNA wrapped into nucleosome arrays remains unclear. Understanding how condensin operates on chromatin fibers is essential, as dysregulation of condensin activity in humans is linked to neurological disorders, cancer, and Alzheimer’s disease. This research aims to explore whether and how condensin extrudes nucleosome arrays by implementing a novel single-molecule chromatin loop extrusion assay. This project aims to (1) examine whether in-vitro-reconstituted densely packed nucleosome arrays affect condensin-mediated DNA loop extrusion; (2) study the impact of internucleosomal linker DNA length on this process; (3) assess the influence of nucleosome compaction by linker histone H1 on condensin-mediated loop extrusion; (4) investigate the enhancement of condensin-mediated DNA loop extrusion by chromatin remodellers. Insights gained from these studies have the potential to significantly advance our understanding of how the condensin complex interacts with chromatin fibers and extrudes these fibers into loops within the cellular environment.

Keywords: genome organization,condensin,single molecule dna loop extrusion,nncleosome arrays,linker histone h1
TIME-Varying Nanophotonics for New Regimes of QED LIGHT-Matter Interactions (TIMELIGHT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Controlling light and its interaction with matter at the nanoscale is one of the major aims of current Science with applications ranging from energy-efficient photonic-based communications, quantum information processing, or high precision sensors. Owing to the hybrid light-matter modes supported by nanophotonic structures, from THz and IR polaritons in 2D materials to optical plasmonic resonances, nanophotonics offers an ideal platform for an exquisite control of light-matter interactions even at room temperature. Light concentrated at the nanoscale is a natural playground for quantum electro-dynamical (QED) processes, whereby light-matter interactions reveal their quantum nature. However, conventional approaches to nanophotonics-based QED are limited by two fundamental principles: energy conservation and reciprocity. Overcoming these limitations would enable non-photon conserving devices and one-way channels, opening the door to a compact route to quantum photonic circuits. TIMELIGHT proposes the use of time-modulated media, whose optical parameters (e.g., permittivity) are dynamically modulated by an external actuation, to realise fundamentally new non-Hermitian and non-reciprocal QED effects. This theoretical project roots in recent experimental advances that have shown unprecedentedly large and fast modulations of nanophotonic structures. TIMELIGHT will deliver advances in the following areas: (1) tuning of spontaneous emission and collective interactions of quantum emitters, (2) new forms of free electron radiation, (3) novel mechanisms for enhancing spontaneous photon generation, and (4) synthetic-motion based fluctuation-induced forces. TIMELIGHT will open the door to time-varying nanophotonics as a new paradigm to tailoring light-matter interactions at room temperature with non-Hermitian and non-reciprocal effects. This will shed light in the understanding of fundamental QED processes and ultimately be of interest to quantum photonic technologies.

Keywords: nanophotonics,light matter interactions,time varying media,temporal metamaterials,macroscopic quantum electrodynamics,polaritons
Physiological adaptations to ecological niches in coccolithophore haplodiplontic life cycle (Cocco-Next)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Croatia
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2022-11-14
End date: 2024-11-13
Duration (months): 24.0
Total project cost (EUR): 161889.6
EU funding (EUR): 161889.6
Participants: 1
Project status: CLOSED

Human CO2 emissions are critically poisoning the earth's climate. However, sedimentation by marine primary producers contributes greatly to carbon sequestration, with coccolithophores, unicellular marine algae with cell envelopes composed of CaCO3, being the key contributors. Nevertheless, the extent of the biogeochemical impact of coccolithophores is largely unknown. They have a dual life cycle and can grow as both haploids and diploids, but past research has focused mainly on the diploid phase. Moreover, knowledge of coccolithophores is almost exclusively limited to a single species that is distributed worldwide, and can form blooms visible from space. However, this species is peculiar in many biological aspects and does not calcify in the haploid phase, therefore we need to develop more model organisms to represent impact of coccolithophores on the carbon cycle. In this action, my objective is to understand how the physiological acclimations of the coccolithophore life cycle phases allow them to inhabit different ecological niches. I will implement a multidisciplinary approach to investigate two levels of complexity: how environmental factors influence physiology and which genes contribute to distinct genetic programs. To this end, I will work on a widespread coccolithophore species that calcifies at both life cycle phases. I will characterize for the first time how photosynthesis (light-driven CO2 fixation) and photoprotection (dissipation of excess energy) differ between the two phases, and determine which environmental conditions trigger ploidy transitions. To investigate the underlying genetic factors, I will then sequence the genome and, in both phases, the transcriptome. Overall, the ambition of the Cocco-Next project is to provide important insights into the interplay between life cycles, ecological niches, and biological CO2 sequestration and beyond, create novel, interconnected and open datasets that will be invaluable to the oceanographic community.

Keywords: coccolithophores,photosynthesis,life cycle,haplodiplontic,genomics,transcriptomics,environmental conditions