Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mechanism of Regulated Transcription Initiation (TRANSIT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: Germany
Call:  (ERC-2010-AdG_20100317, 2010)
Start date: 2011-05-01
End date: 2016-04-30
Duration (months): 60.0
Total project cost (EUR): 2226067.0
EU funding (EUR): 2226067.0
Participants: 2
Project status: CLOSED

The regulation of gene transcription governs eukaryotic cell growth and differentiation. Despite its importance, transcription regulation is not understood at a mechanistic level. Regulation occurs mainly during initiation, when the enzyme RNA polymerase II (Pol II) assembles with ~50 polypeptides on promoter DNA. Regulatory signals are transmitted by the 25-subunit Mediator, and convert the initiation complex into a productive elongation complex. Ten years after the solution of the Pol II structure (Cramer et al., Science 2000, 2001), elongation is understood, but the structure and regulatory control of the initiation complex remain largely unknown. Here I propose to solve this central problem of molecular genetics and obtain a movie that shows how a gene is activated. Our recent structure of Pol II with initiation factor TFIIB (Kostrewa et al. Nature 2009) provides the starting point for the proposed risky and challenging structure-function analysis of regulated initiation. First, we will determine structures of Pol II in the initiating state. Second, we will solve the structure of the essential, gene-regulatory 7-subunit head module of the Mediator core. Third, we will establish ¿nascent transcriptome analysis¿ as a novel technique that measures mRNA synthesis rates globally, and will use it to probe the mechanisms of regulated initiation by structure-based mutagenesis in vivo. Expected results will open new horizons for investigating the function of eukaryotic genomes, and will have a strong impact on biomedicine, since deregulated transcription underlies many diseases, including cancers and certain metabolic dysfunctions. This ground-breaking research requires the long-term, flexible commitment of the ERC, to successfully compete with teams in the US and Japan.
High-resolution tweezers for DNA replication and sequence identification (MAGREPS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: ERC Advanced Grant Interdisciplinary Panel
Countries involved: France,Spain,United States
Call:  (ERC-2010-AdG_20100224, 2010)
Start date: 2011-09-01
End date: 2016-08-31
Duration (months): 60.0
Total project cost (EUR): 2193566.0
EU funding (EUR): 2193566.0
Participants: 3
Project status: CLOSED

We propose to investigate the enzymes responsible for DNA replication and repair in micromanipulation experiments with a resolution of a single base. The detailed mechanism by which DNA is synthesized base after base and the coordination of the enzymes involved in this process are not fully understood. We shall develop new magnetic tweezers using lithographic techniques associated with evanescent field detection to address these issues. We shall build arrays of these devices working in parallel, each one on a single DNA molecule and where the measurement of its extension reveals enzymatic activity. The DNA molecule in these devices will form a hairpin the opening of which can be detected with a single base resolution. We will study the different enzymes involved in DNA replication. Firstly, we wish to follow in real time the incorporation of bases one by one by a DNA-polymerase and investigate the proof-reading mechanism of this enzyme. We shall also investigate the translocation mechanisms of different helicases involved in DNA replication and repair. Finally, we plan to study the cooperative action between different enzymes involved in the replication machinery with the help of parallelized micro-tweezers: the coupling between helicase and primase in the lagging strand synthesis, the coupling between the helicase and polymerase during leading strand synthesis and the coordination between leading and lagging strand synthesis. Moreover observing a DNA-polymerase at the single base level is the first step of a DNA sequencing method. Preliminary experiments demonstrate that the unzipping assay is a new way to determine the position of a small DNA sequence with single base resolution. We shall investigate different experimental schemes to achieve this goal.

Keywords: magnetic tweezers,micromanipulation,single molecule,replisome,dna mechanical sequencing
ASTERoseismic Investigations with SONG and Kepler (ASTERISK)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Universe sciences
Countries involved: Denmark
Call:  (ERC-2010-AdG_20100224, 2010)
Start date: 2011-04-01
End date: 2016-03-31
Duration (months): 60.0
Total project cost (EUR): 2498149.0
EU funding (EUR): 2498149.0
Participants: 1
Project status: CLOSED

The project aims at a breakthrough in our understanding of stellar evolution, by combining advanced observations of stellar oscillations with state-of-the-art modelling of stars. This will largely be based on very extensive and precise data on stellar oscillations from the NASA Kepler mission launched in March 2009, but additional high-quality data will also be included. In particular, my group is developing the global SONG network for observations of stellar oscillations. These observational efforts will be supplemented by sophisticated modelling of stellar evolution, and by the development of asteroseismic tools to use the observations to probe stellar interiors. This will lead to a far more reliable determination of stellar ages, and hence ages of other astrophysical objects; it will compare the properties of the Sun with other stars and hence provide an understanding of the life history of the Sun; it will investigate the physical processes that control stellar properties, both at the level of the thermodynamical properties of stellar plasmas and the hydrodynamical instabilities that play a central role in stellar evolution; and it will characterize central stars in extra-solar planetary systems, determining the size and age of the star and hence constrain the evolution of the planetary systems. The Kepler data will be analysed in a large international collaboration coordinated by our group. The SONG network, which will become partially operational during the present project, will yield even detailed information about the conditions in the interior of stars, allowing tests of subtle but central aspects of the physics of stellar interiors. The projects involve the organization of a central data archive for asteroseismic data, at the Royal Library, Copenhagen.

Keywords: asteroseismology
Designing new technical wastewater treatment solutions targeted for organic micropollutant biodegradation, by understanding enzymatic pathways and assessing detoxification (ATHENE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Products and process engineering
Countries involved: Germany,Switzerland,Germany
Call:  (ERC-2010-AdG_20100224, 2010)
Start date: 2011-04-01
End date: 2017-03-31
Duration (months): 72.0
Total project cost (EUR): 3473400.0
EU funding (EUR): 3473400.0
Participants: 3
Project status: CLOSED

The identification of degradation pathways relevant for organic micropollutants in biological wastewater treatment processes is currently a major gap, preventing a profound evaluation of the capability of biological wastewater treatment. By elucidating the responsible enzymatic reactions of mixed microbial populations this project will cover this gap and thereby allow finding technical solutions that harness the true potential of biological processes for an enhanced biodegradation and detoxification. Due to the multi-disciplinary approach Athene will have impacts on the fields of biological wastewater treatment, analytical and environmental chemistry, environmental microbiology, water and (eco)toxicity. The multi-disciplinary approach of the project requires the involvement of a co-investigator experienced in process engineering and microbiology in wastewater treatment. Athene will go far beyond state-of-the-art in the following fields: a) efficiency in chemical analysis and structure identification of transformation products at environmental relevant concentrations; b) identification of enzymatic pathways relevant for micropollutant degradation in biological wastewater treatment; c) designing innovative technical solutions to maximize biodegradation; d) map and model relevant enzymatic pathways for environmental concentrations. Furthermore, designing biological wastewater treatment processes by understanding enzymatic pathways relevant for organic micropollutants removal represents a paradigm shift for municipal wastewater treatment. In the context of the actual scientific discussion about the relevance of trace organics in the aquatic environment and in drinking water, this topic is deemed as highly innovative: for its potential of proposing new technical options as well as for the gain in understanding compound persistency. Finally enzymatic reactions as well as the treatment schemes will be assessed for there capability to reduce toxiciological effects.
Mastering the dusty and magnetized Interstellar Screen to Test Inflation Cosmology (MISTIC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Universe sciences
Countries involved: France
Call:  (ERC-2010-AdG_20100224, 2010)
Start date: 2011-06-01
End date: 2016-05-31
Duration (months): 60.0
Total project cost (EUR): 1755000.0
EU funding (EUR): 1755000.0
Participants: 1
Project status: CLOSED

How did the Universe begin? The prevailing idea is that the Bang of the Big Bang was an early burst of exponential expansion, dubbed inflation. A key prediction of inflation is that it generated gravitational waves. The corresponding ripples in the space-time geometry left an imprint in the polarisation of the Cosmic Microwave Background (CMB). A new generation of experiments are making a major step towards this signal by mapping the microwave sky polarisation with an unprecedented sensitivity and combination of sky coverage, angular resolution and wavelengths. These experiments may show whether the energy scale of inflation predicted by the simplest models is correct. However, unlike for temperature anisotropies, Galactic foregrounds have larger amplitude than any putative primordial B-mode signal. The signature of cosmic inflation will not be detected, unless contamination associated with the dusty and magnetized interstellar medium in the Galaxy is removed with the required accuracy and confidence. Within the competitive field of CMB studies, the MISTIC project proposes a unique contribution to the search for its B-mode polarisation. The MISTIC team has the unmatched ambition and capability to tie the analysis of polarisation data and component separation to state-of-the-art understanding and modelling of the dusty magnetized interstellar medium. Our project goal is to achieve the breakthroughs in the fields of Galactic astrophysics, microwave sky modelling, and component separation, required to achieve the best sensitivity on the B-mode CMB polarisation. Our work plan bridges data analysis, physical modelling, sky modelling and component separation into an iterative process that will take full advantage of the uniqueness and complementarities of expertise and data gathered in the MISTIC project.
Re-integration of a skilled researcher through an intra-European collaboration on pathology-specific bone cements (SPINEGO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-11-01
End date: 2013-10-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

This project aims to re-integrate a skilled researcher and strengthen the European research network in biomedical engineering.The optimal outcome is new treatment options for vertebral fractures in order to reduce the pain and improve the stability of the spine.Bone cements are frequently used to treat vertebral fractures, but may cause adjacent fractures due to their high stiffness.This is particularly an issue during their increasingly frequent application to osteoporotic fractures,where the surrounding bone is of poor quality.Furthermore,other diseases which affect the bone quality (on a focal or generalised level) indicate the need for different cement properties.This project aims to develop and evaluate pathology-specific bone cements.The first objective is to develop a target profile through imaging and mechanical testing of vertebrae.Secondly,cements of various properties will be developed and tested using standard protocols.Their spreading characteristics will also be evaluated using surrogate models.Finally,their efficiency will be assessed through in vitro testing on human vertebral bone. The researcher has a strong background in both bone cements and spinal research. She has successfully completed various research projects and been the lead author on international publications.The project will be implemented through a collaboration between the previous–University of Leeds-and the new-Uppsala University-host.Substantial advantages will be drawn by all parties through the synergy created between an expertise in biomaterials (Uppsala) and biomechanics (Leeds) and both hosts will benefit from a reciprocal knowledge transfer.Both institutions have a strong international reputation and excellent facilities which will assist in a timely completion of the project.It is expected that this opportunity will allow the researcher to build a strong research profile in the spinal biomedical field and ultimately become a competent European research leader of the future.

Keywords: biomaterial engineering,biomedical engineering
Technology platform Operational Programme Wind (TOP WIND)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable electricity generation
Action type: Coordination and support actions
Countries involved: Belgium,Denmark,United Kingdom
Call:  (FP7-ENERGY-2010-2, 2010)
Start date: 2011-02-01
End date: 2014-04-30
Duration (months): 39.0
Total project cost (EUR): 1029950.0
EU funding (EUR): 897050.0
Participants: 3
Project status: CLOSED

The European Wind Energy Technology Platform (TPWind), established in 2005, is today a well-established and broadly recognized network of approximately 150 wind energy experts, who play a key role in supporting the development of wind power in Europe. For the last three years, the costs of its Secretariat, hosted by the EWEA in Brussels, have been covered by the FP6 “Windsec” project, which was very successfully managed in partnership with Risoe/DTU and Garrad Hassan. The main aim of the TOP Wind project will be to ensure the proper functioning of the European Wind Energy Technology Platform over the 2010 – 2013 period, as well as to increase its effectiveness, impact, visibility and network (especially by reinforcing existing relationships, and developing new ones, with oil & gas, ocean and grids operators, who can cooperate with wind energy players to reduce fragmentation of EU R&D activities). Thanks to the publication in 2008 of its Strategic Research Agenda / Market Deployment Strategy, which quickly became a reference document in the wind power sector, and to its contribution to the development of the Wind Energy Roadmap (published by the EC in October 2009 in its Communication on Financing Low Carbon Technologies), the Platform is playing a central role in shaping wind energy in Europe. TOP Wind, which builds on the experience gained by partners during the implementation of the Windsec project, will therefore reinforce the Platform, streamline its activities, expand its membership base and enhance its links with all relevant stakeholders, so as to further increase the efficiency and competitiveness of research in the field of wind energy and to maximize synergies with oil & gas, grid and maritime sectors to avoid duplication of efforts.

Keywords: wind energy technology platform research innovation clean renewable network agenda roadmap
Probing Europe’s Undiscovered Genome: A Metagenomics Approach to Find Unique Enzymes for the Biofuel and Bioprocessing Industries (EUROPE’S METAGENOME)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-11-01
End date: 2014-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Our civilization is facing increasing pressures on finite natural resources, and Europe in particular faces serious challenges to its energy security. The purpose of the project is to explore Europe’s unique environments to discover novel enzymes which may support the development of viable bioenergy and other bioprocessing industries. Hydrogen has great potential as a future energy source. To make biological hydrogen production more favorable and competitive, more powerful hydrogenases needs to be discovered. Various kinds of enzymes such as lipases and cellulases are used as biocatalysts for a variety of bioprocessing industries; however there is still a strong need for new generations of these enzymes with more favorable characteristics such as stability to extremes of temperature, pressure, and pH. In this research, a metagenomics approach will be used to target the discovery of novel enzymes by exploring the world of unknown microorganisms in Europe. Finally, to fully achieve the goal of creating more powerful enzymes, directed evolution approaches will be applied. The anticipated result of this research is to discover highly effective hydrogenases, cellulases, and lipases. This project aims to provide tremendous environmental, economic, and strategic benefits and improve the quality of human life. The enzymes discovered may have a big influence and increase the competitiveness of Europe. The specific objectives of this research are to: (1) create metagenomic libraries using genomic DNA isolated directly from European water and soil samples (2) using activity based agar plate screening, discover novel hydrogenases, cellulases, and lipases (3) isolate and identify the sequences of the enzymes and clone novel ones into an expression host strain (4) explore their potential for application by evaluating their activities, substrate specificities, and stabilities at temperature and pH extremes (5) enhance the characters of isolated enzymes using directed evolution.

Keywords: metagenomics,enzyme discovery,directed evolution,family shuffling,hydrogenase,lipase,cellulase,biofuel,bioprocessing
Support to the activities of the European Technology Platform on Renewable Heating and Cooling (SECRHC-PLATFORM)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewables for heating and cooling
Action type: Coordination and support actions
Countries involved: Belgium,Belgium
Call:  (FP7-ENERGY-2010-2, 2010)
Start date: 2011-01-01
End date: 2014-06-30
Duration (months): 42.0
Total project cost (EUR): 1109632.32
EU funding (EUR): 999423.41
Participants: 4
Project status: CLOSED

This proposal aims at establishing a secretariat to support the activities of the European Technology Platform on Renewable Heating and Cooling. Such a Platform was launched in December 2008 with a view to bringing together stakeholders from the solar thermal, biomass and geothermal sectors, as well as related technologies (e.g. heat pumps, construction, district heating and cooling), to draft a common research and policy strategy for the whole renewable heating and cooling sector.

Keywords: support activities,renewable heating and cooling sector,solar thermal,geothermal,biomass,cross-cutting issues,shared strategic research priorities,shared policy issues
Study on Low-power Multi-Gbps Ultra-Wideband Impulse Radio at License-free UWB and 60GHz bands (UWB-IR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-11-01
End date: 2014-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Ultra-Wideband Impulse Radio (UWB-IR) has an advantage of providing high data-rate with lower power consumption than conventional complex quadrature modulated radios, such as orthogonal frequency modulation (OFDM) with quadrature phase shift keying (QPSK) or 16 quadrature amplitude modulation (QAM). The requirement of large bandwidth is the disadvantage of UWB-IR since license-fee of bandwith requires high cost. But, in 2002, three ultra-wideband frequencies are allocated for license-free applications. From 3.1 to 10.6GHz microwave band called as UWB and 59 to 66GHz millimeter-wave bands are allocated for wireless communication and 22-29GHz pseudo millimeter-wave band is allocated for short-range collision avoidance automobile radar applications. UWB and 60GHz bands are suitable for low-power several Gbps wireless communication. Every day, low-power and high-speed new consumer electronics appliances are appearing in the market such as digital camera, laptop, iPot, etc. These devices need to communicate each other with more than 1 Gbps data-rate where the power consumption of the transceiver is main issue not to reduce the battery life time especially when the communication speed is faster than 1 Gbps data-rate. This research will contain multi-displinary study where we are doing to design radio-frequency integrated circuits, antennas, microwave impulse circuits and customized test structures to study the low-power multi-Gbps UWB-IR. Low-power multi-Gbps UWB-IR at license free bands are going to be investigated for widespread public benefit.

Keywords: low-power,gbps,cmos,uwb,impulse radio,60ghz,millimeter-wave