Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Micromechanics of rock fracture: enabling energy-efficient mining through next generation cracking models (MICROCRACK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Mining is a huge industry that accounts for a very significant share of global energy consumption, with rock comminution being responsible for – at least – half of the total energy expenditure. There is, consequently, a strong need to develop innovative energy-efficient mining techniques, and this proposal will focus on this major opportunity. A physically-based constitutive framework for anisotropic cracking of heterogeneous rocks will be developed, laying the scientific foundations for micromechanical modelling of rock fracture. The model will embed the mechanisms governing cracking of heterogeneous rocks in a novel and interdisciplinary approach. The complementary profile of the applicant and the host group is a strong asset, with their previous experience in micromechanics and fracture establishing the basis to successfully overcome the theoretical, numerical and experimental challenges of the project. The proposal builds upon the applicant’s background and involves new research areas, widening his competences and supporting development to academic maturity. An appropriate work plan has been programmed to achieve the scientific objectives and ensure knowledge transfer. Milestones and deliverables have been established to monitor the progress of the project implementation and pertinent corrective measures projected. A detailed dissemination strategy has been proposed to communicate findings to the general public, and to increase the impact of the research outcomes in the scientific community and engineering practice. The Cambridge Centre for Micromechanics provides an optimum environment for the project, containing the facilities required to perform the indispensable critical experiments and advanced numerical simulations. Moreover, it constitutes a unique platform to develop international, intersectoral and interdisciplinary recognition, supporting the applicant in achieving a breakthrough that will significantly impact his scientific career.

Keywords: fracture,micromechanics,finite element method,damage,cracking
Implementation of Enzymatic Activity in a Naïve, de novo Designed Protein Scaffold by Rational Design and Laboratory Evolution (TIMEnzyme)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

The proposed research project aims at implementing enzymatic activity in a de novo designed, unbiased protein scaffold. First, simplified active site arrangements deduced from two previously evolved model enzymes (Kemp eliminase and retro-aldolase) will be implanted in the scaffold. This will allow evaluating the extent to which a fully computationally designed and naïve protein can be functionalized and evolved. A recently established fluorescence-based microfluidics setup will be utilized to screen large DNA libraries of several million clones per round of laboratory evolution. The artificial protein scaffold, kindly provided by Prof. David Baker (University of Washington), has been designed to adopt a minimalist TIM barrel fold, which is the most abundant and diversely evolved protein fold found for natural enzymes. Here, the substrate binding pocket is usually formed by an extended loop region on one side of the scaffold, which is not yet present in the naïve, designed variant. Thus, in the second step, I will generate a randomized library of loop fragments, insert into the scaffold and screen for improved activity. This approach can be extended from the retro-aldolase model reaction towards synthetic aldolases that catalyze the stereospecific formation of a new carbon-carbon bond. Ultimately, the aim is to evaluate whether loop libraries are an appropriate tool to broaden the substrate scope of these enzymes. Furthermore, the proposal contains a second, independent approach to equip the artificial scaffold with novel enzymatic functionality. Here, I plan to design a covalent dimer of two artificial TIM barrels carrying a cofactor-dependent active site in the dimeric interface. This work will not only generate fundamental insight into the evolution of catalytic activity, it also has great potential to contribute to the development of general strategies for creating enzymes with novel functionality, and thus, prospective applications in industry or medicine.

Keywords: enzyme design,directed evolution,protein engineering
OncoMasTR - Novel Prognostic Assay for Early Stage Breast Cancer (OncoMasTR)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Ireland
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-2-2015, 2015)
Start date: 2016-02-01
End date: 2018-01-31
Duration (months): 24.0
Total project cost (EUR): 2751250.0
EU funding (EUR): 2751250.0
Participants: 1
Project status: CLOSED

OncoMark Ltd are developing a novel, game-changing breast cancer prognostic assay, called OncoMasTR, which has the potential to transform clinical practice and patient care. OncoMasTR will help clinicians to decide which patients should receive chemotherapy for early stage breast cancer, which is a pressing clinical and economic issue worldwide. OncoMasTR is more cost-effective than competitor assays, demonstrates superior performance clinically, generates a user-friendly binary (yes/no) output and can be carried out on-site using standard equipment. Our principal aim is to develop OncoMasTR as a CE marked kit, and penetrate a global market. OncoMasTR comprises a novel panel of biomarkers of tumour progression, measured by qRT-PCR using standard procedures and equipment. Objectives for Phase 2 are to analytically, clinically and commercially validate the OncoMasTR prototype under ISO13485 standards, using two large cohorts of breast cancer patients. Access to tissues from a prospective clinical trial will enable us to benchmark OncoMasTR’s performance against the leading competitor assay. Communication and dissemination of data will be key to building a strong base of OncoMasTR ambassadors in the clinical arena, and to leverage private investment in OncoMark for development of other products in our pipeline. OncoMasTR will bring OncoMark into the clinical biomarker arena and will positively impact healthcare costs in the EU and globally.

Keywords: breast cancer,prognostic,assay,oncology,biotechnology
Diesel efficiency improvement with Particulates and emission Reduction (DiePeR)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Spain,Germany,Italy,Italy,Germany,Austria,Switzerland,France,France,France,Netherlands,United Kingdom,United Kingdom
Call: Technologies for low emission light duty powertrains (H2020-GV-2016-INEA, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 8645405.0
EU funding (EUR): 7211029.75
Participants: 17
Project status: CLOSED

Growing road traffic in Europe results in detrimental effects on the environment and public health to a level that is becoming unsustainable, this in spite of increasingly stringent emission standards. In particular, CO2 and noxious emissions are not sufficiently reduced in real driving, while higher injection pressures have led to a shift towards the emission of smaller nanoparticles that are undetected by current certification procedures. The challenge of the DiePeR project is to apply advanced technologies for combustion and exhaust aftertreatment to existing non-hybrid Diesel engines and to optimize the improved characteristics of a new generation of engines with regard to emissions, fuel consumption and driveability. Specific technologies will be advanced to TRL 6 or TRL 7 and integrated in two demonstration vehicles: One passenger car of the mid/ premium segment and one light commercial vehicle. A full calibration and assessment of the vehicles and underlying technologies will take place to proof: Real driving emissions substantially below Euro 6/ NEDC limits, less than half of emitted particles (number) including particles < 23nm and a more than 5% improved fuel efficiency based on best-in-class MY2015 vehicles. The project also addresses design features, control and basic research such as modelling of particles formation and the deterioration of engine components (fuel injection system, exhaust aftertreatment system) and its effect on emissions, in order to assess the robustness of the vehicles over useful lifetime.

Keywords: particulates,emission reduction
Mining and Metallurgy Regions of EU (MIREU)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Coordination and support actions
Countries involved: Austria,Germany,Spain,Spain,Spain,Ireland,Spain,Austria,Belgium,Finland,Romania,Finland,Greece,Poland,Slovakia,Sweden,Poland,Sweden,Finland,France,France,France,United Kingdom,Chile,United Kingdom,Portugal,Portugal
Call: Raw materials policy support actions (H2020-SC5-2017-OneStageB, 2017)
Start date: 2017-12-01
End date: 2021-04-30
Duration (months): 41.0
Total project cost (EUR): 2999725.0
EU funding (EUR): 2999725.0
Participants: 35
Project status: CLOSED

The project MIREU aims to establish a network of mining and metallurgy regions across Europe with a view to ensure the sustained and sustainable supply of mineral raw materials to the EU. The network will help the regions to share knowledge and experiences when facing the challenge to establish and maintain an extractive industry. MIREU will facilitate an exchange between all interested stakeholders in the regions, namely regulatory authorities, political and administrative bodies, development agencies, mining companies, non-government organisations, as well as the general public. The project will develop a shared knowledge base, taking into account the region-specific geographic and economic features, cultural, societal and language diversity, and their historical developments. The network will also learn from experience in other regions of the World. This knowledge base will allow to understand what has been conducive and what hampering to the development of extractive and metallurgical industries. It will also provide the context for a bottom-up integration of these activities into their respective socio-economic and socio-cultural context. Development is about people and, therefore, bringing people into the decision-finding procedure in order to achieve a ‘social license to operate’ will be a key aspect of the project. Guidelines and recommendations for actions to be taken to foster a sustained and sustainable development of the extractive industries will be developed in close co-operation with a range of selected regions from the European Union. These regions will form a nucleus and multipliers for a more extensive network beyond the life-time of the project.

Keywords: regional network,regional development,mining region,social acceptance,region,mining,metallurgy,development
Unraveling Turbulence through Ensemble Decomposition (UniTED)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany,Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 1724375.0
Participants: 2
Project status: SIGNED

Turbulence governs essentially all large-scale flows on our planet, including our atmosphere and oceans. With a vast number of engineering applications in transportation technology, renewable energies, and more, turbulence has a direct impact on our lives. However, developing predictive theories of turbulence, which ultimately all modeling applications rely on, remains one of the outstanding scientific challenges. Moreover, while massive simulations on the largest supercomputers are nowadays an established tool, reaching realistically high Reynolds numbers remains prohibitive. Already today, analyzing the sheer amount of peta-scale simulation data requires new paradigms for making meaningful progress. Fundamentally new approaches are needed to achieve a breakthrough. UniTED will deliver such an approach by a unique, synergistic combination of data-driven theory and large-scale computations. How? Recently, I showed that the complex statistics of turbulence can be disentangled into much simpler sub-ensembles. This significant reduction of complexity points toward exciting new theoretical pathways and novel computational methodologies, which I will explore in this project. In UniTED, we will (A) dissect the multi-scale structure of turbulence through massively parallel computations. This will (B) provide the foundation for a statistical theory of turbulence which is based on a novel ensemble decomposition approach. Combining (A) and (B), we will (C) develop a novel ensemble-based simulation approach, enabling unprecedented insights into turbulence at high Reynolds numbers. We will then use this approach to (D) provide big data for modeling small-scale turbulence using physics-informed machine learning. UniTED will boost our fundamental understanding of turbulence at very high Reynolds numbers and provide new modeling approaches in a breadth of fields such as computational engineering, the Earth sciences, renewable energy, and plasma physics.

Keywords: turbulence,computational fluid dynamics,statistical field theory,reduced order models
Scalability Investigation of hybrid Electric concepts for Next-generation Aircraft (SIENA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Germany,Italy,Ireland
Call: Scalability and limitations of Hybrid Electric concepts up to large commercial aircraft (H2020-CS2-CFP11-2020-01, 2020)
Start date: 2021-02-01
End date: 2023-07-31
Duration (months): 30.0
Total project cost (EUR): 764148.33
EU funding (EUR): 764148.33
Participants: 4
Project status: SIGNED

The project presented in this proposal has the ambition to accelerate the development of hybrid electric A/C technologies in larger vehicles through the identification of scalable technologies that are reusable across vehicle classes. Economic, operational and regulatory aspects, will be considered in the project beyond the technical considerations. The project presented in this proposal has the ambition to accelerate the development of hybrid electric A/C technologies in larger vehicles through the identification of scalable technologies that are reusable across vehicle classes. Economic, operational and regulatory aspects, will be considered in the project beyond the technical considerations. Those include key elements such as impact on infrastructure, vehicle safety, operational reliability and industrial competitiveness, thus ensuring that the technologies proposed are not only technically feasible but viable for the industry as a whole. The early identification of radical technologies and architectures will help identifying early in the process regulatory gaps that need to be addressed to ensure that regulations and technologies development progress at the same pace. United Technologies Research Centre Ireland and Politecnico di Milano will partner to enhance the design process for radical hybrid electric propulsion architectures through the Scalability Investigation of hybrid Electric concepts for Next-generation Aircraft: SIENA project. SIENA introduces an innovative notion of scalable-by-design aircraft concepts by performing an automated and exhaustive design space exploration and systematic analysis of novel technologies, and their integration in new vehicle architectures. Additionally, the technologies and architectures evaluation process will be enhanced by innovative machine learning algorithms, while taking into account economic and operational considerations. The generated breakthroughs will guide upcoming projects under Horizon Europe program.

Keywords: hybrid electric propulsion,scalable hybrid electric technologies,scalable hybrid electric architecture,cs 23 regulatory gap,cs 25 regulatory gap,hybrid electric propulsion operational viability
Super-Kamiokande plus (SKPLUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,Poland,Poland,Japan
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2014-12-01
End date: 2018-11-30
Duration (months): 48.0
Total project cost (EUR): 310500.0
EU funding (EUR): 310500.0
Participants: 4
Project status: CLOSED

This proposal is a part of ongoing global efforts to understand the most fundamental elements of matter and their interactions. We aim to investigate neutrino interactions using the existing experimental facility in Japan, the Super-Kamiokande (SK) detector located in the Kamioka Observatory (Gifu Prefecture) and owned by the Partner of this Project: the Institute for Cosmic Ray Research of the University of Tokyo. Furthermore, we propose a joint work on the design and construction of new neutrino detectors planned at the Kamioka Observatory. They are Gadzooks! (and its R&D program EGADS), that is an extension to SK, and Hyper-Kamiokande (HK), its next generation detector. These Projects are currently ongoing and in preparation phase, respectively. We address several fundamental problems in physics. We do it at different stages: by analyzing the data from SK, by building and commissioning Gadzooks!, and by designing HK: • Neutrino Oscillations – neutrino mass hierarchy (SK, Gadzooks!, HK), leptonic Charge-Parity violation (HK), precise measurement of mixing parameters (SK, Gadzooks!, HK), • Dark Matter – search for neutrinos induced by dark matter annihilation/decay in the cosmic space (SK, HK), • Nearby Galactic Supernova Physics – measurement of neutrinos emitted in the burst (SK, Gadzooks!, HK), • Diffuse Supernova Neutrino Background – discovery (Gadzooks!) and energy spectrum measurement (HK), • Grand Unification – search for proton decay (SK, Gadzooks!, HK). Seconded researchers will work in Japan on those investigations. The collaborative work with the leaders of the field, the Japanese Groups and Research Facilities, should assure the researches and the Participants Groups the gain of an invaluable experience from these studies ,covering neutrino physics, cosmology, astrophysics, technical design, construction and operation of water Cherenkov detectors, data analysis techniques, hardware and software development for the new generation detectors.

Keywords: neutrino,water cherenkov,super kamiokande,gadzooks,hyper kamiokande,t2hk,mixing,mass hierarchy,cp violation,supernova,dark matter,diffuse supernova neutrino background,proton decay
A generic CMOS-compatible platform for co-integrated plasmonics/photonics/electronics PICs towards volume manufacturing of low energy, small size and high performance photonic devices (PLASMOfab)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Germany,Austria,Israel,Austria,Germany,Germany,Switzerland,Greece,France,France,Netherlands
Call: Photonics KET (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 4150246.25
EU funding (EUR): 3580691.25
Participants: 11
Project status: CLOSED

PLASMOfab aims to address the ever increasing needs for low energy, small size, high complexity and high performance mass manufactured PICs by developing a revolutionary yet CMOS-compatible fabrication platform for seamless co-integration of active plasmonics with photonic and supporting electronic. The CMOS-compatible metals Aluminum, Titanium Nitride and Copper, will be thoroughly investigated towards establishing a pool of meaningful elementary plasmonic waveguides on co-planar photonic (Si, SiO2 and SiN) platforms along with the associated photonic-plasmonic interfaces. The functional advantages of PLASMOfab technology will be practically demonstrated by developing two novel functional prototypes with outstanding performances: 1) a compact, plasmonic bio-sensor for label-free inflammation markers detection with multichannel capabilities and record-high sensitivity by combining plasmonic sensors with electrical contacts, Si3N4 photonics, high-speed biofunctionalization techniques and microfluidics 2) a 100 Gb/s NRZ transmitter for datacom applications by consolidating low energy and low footprint plasmonic modulator and ultra high-speed SiGe driving electronics in a single monolithic chip. The new integration technology will be verified through wafer-scale fabrication of the prototypes at commercial CMOS fabs, demonstrating volume manufacturing and cost reduction capabilities. PLASMOfab technology will be supported by an EDA software design kit library paving the way for a standardized, fabless plasmonic/photonic IC eco-system.

Keywords: photonic integrated circuit,plasmonic waveguide,silicon photonics,cmos technology,100 gb,s electronics,plasmonic modulator,monolithic integration,multi channel sensing,biomarker detection