Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
OneBiosecurity Systems and Technology for People, Places and Pathways (OneSTOP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Innovation actions
Countries involved: Belgium,Denmark,United Kingdom,Portugal,Cyprus,Czechia,New Zealand,Bulgaria,South Africa,Austria,Hungary,Germany,Romania,Finland
Call: Invasive alien species (HORIZON-CL6-2024-BIODIV-01, 2024)
Start date: 2025-01-01
End date: 2028-06-30
Duration (months): 42.0
Total project cost (EUR): 6337799.38
EU funding (EUR): 5999990.0
Participants: 21
Project status: SIGNED

The overarching objective of OneSTOP is to pioneer an innovative and joined-up approach to biosecurity for terrestrial invasive alien species, strengthening the interconnections between animal, plant, human and environmental health. OneSTOP aims to harness current technologies and citizen science, while overcoming challenges posed by dispersed and fragmentary processes, policies, and knowledge, to deliver methods for identification, early detection and surveillance of invasive alien species. OneSTOP aims to achieve transformative results to minimise the introduction, establishment and spread of invasive alien species by integrating cutting-edge detection methods, underpinned by prioritisation and robust models, alongside stakeholder engagement to inform harmonised policies and facilitate knowledge exchange. The outcomes will be relevant for invasive alien species policy, noting the importance of enhancing collaboration and coordination across local, national, and regional scales, recognising that geographic boundaries do not confine the impact of these species. By adopting a holistic and interconnected approach, OneSTOP seeks to establish a strategy to achieve rapid and transformative progress in detecting, eradicating and controlling invasive alien animals and plants, ultimately contributing to a more secure and resilient environment. Throughout, OneSTOP is based upon the strategic actions recommended for integrated governance of biological invasions in the recently published IPBES Thematic assessment report on invasive alien species and their control (IPBES 2023).

Keywords: species detection early warning,rapid response,data integration,species prioritization,pathway prioritization,living labs,citizen science,sentinel gardens,invasive species impact
Unified No-Code platform for Interactive Cultural Heritage Experiences (UNICHE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Innovation actions
Countries involved: Luxembourg,Greece,Poland,Italy,Spain,Germany,Hungary
Call: A European Collaborative Cloud for Cultural Heritage – Innovative tools for high-value interactions with visitors and heritage objects (HORIZON-CL2-2024-HERITAGE-ECCCH-01, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 4193678.46
EU funding (EUR): 3608915.55
Participants: 13
Project status: SIGNED

The UNICHE project aspires to co-design and create an intuitive, technology-agnostic "black-box" platform as a “no-code”, single-entry, collaborative tool for effortlessly designing, producing and sharing high-quality, interactive, cultural heritage experiences. With its user-friendly system, CH institutions and professionals, researchers, CI freelancers and resource limited players will be able to collaborate and generate high value interactive content in multiple formats (multimodal). UNICHE’s approach prioritizes ease of use and minimizes the technical expertise required, ensuring broad accessibility for diverse users and their audiences. By leveraging and integrating existing advanced technologies and tools developed by the consortium, UNICHE’s platform (Repository, Authoring Environment, Experience Apps and Evaluation tool) addresses in a holistic way the four E’s: Exhibits, Experience design, Exhibitions and Evaluation processes. Direct access and inclusion of exhibits from existing data spaces at the EU and Member States’ levels through the European Collaborative Cloud for Cultural Heritage (ECCCH) is a fundamental aspect of the project, addressing key challenges in cultural heritage institutions. The cultural content (exhibits) channeled through the ECCCH is utilised and repurposed in the AI-assisted Experience design process and presented through the Exhibition phase (Onsite, Hybrid and Remote), in which Evaluation processes are put in place to inform the enhancement of visitor engagement. UNICHE’s approach will firstly be evaluated in Pilot scenarios that represent diverse cultural heritage settings: open-air archaeological sites, museum permanent exhibitions and portable exhibitions and secondly will be further tested through an open call to third parties, inviting them to use the platform, fostering a community of small cultural heritage institutions and creative industry professionals.

Keywords: cultural experiences,eccch compliant tools and applications,experience authoring environment,visitor behaviour analysis,ai enabled cultural content management
Unraveling the peroxisome-associated mechanisms counteracting ferroptosis during quiescence (PEROXISCENCE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 200400.0
EU funding (EUR): 200400.0
Participants: 3
Project status: SIGNED

Quiescence, a temporary cellular state of non-proliferation, is widespread in nature. Quiescent fungi often cause persistent infections resistant to conventional treatments. Quiescence is maintained via the consorted action of several regulatory pathways. In yeast, these include stabilization of the eisosome-localized, ubiquinol-generating Flavodoxin-like proteins (FLPs), recently shown by my host labs to counteract ferroptosis, a form of iron-dependent cell death promoted by peroxidised phospholipid (PL) accumulation at the plasma membrane. Importantly, new results suggest that lack of eisosomes or FLPs disrupts peroxisome biogenesis and function, i.e. fatty acid β-oxidation. PEROXISCENCE focuses on the data-driven hypothesis that increased PL peroxidation rewires certain Membrane Contact Sites (MCSs), leading to channeling of fatty acids towards PL remodeling instead of β-oxidation, to compensate for defective repair. I will investigate this model by employing a multidisciplinary approach, including genetics, a split-Venus-based screening of peroxisomal MCSs, lipidomics and a secondment for training in STED microscopy, with the goals to 1) identify the enzymes involved in PL remodeling and determine their role in counteracting ferroptosis, 2) determine if eisosomes and PL peroxidation regulate fatty acid flux by affecting MCSs, and 3) elucidate the role of Pex11, a protein implicated in the formation of tethers at peroxisomal MCSs. The outputs of PEROXISCENCE are expected to provide novel scientific knowledge with an impact on the fields of cell biology, ferroptosis, aging, and fungal pathogenicity. Furthermore, understanding the mechanisms of lipid homeostasis in quiescence could lead to the identification of innovative ways to tackle persistent fungal infections. With a strong background in molecular microbiology and microbial biotechnology, PEROXISCENCE is the ideal project for expanding my expertise in the field of cell and molecular biology of S. cerevisiae.

Keywords: yeast,eisosomes,membrane contact sites,ferroptosis,peroxisome,phospholipid,remodeling,beta oxidation,saccharomyces cerevisiae,lipids,membrane domains,quiescence,aging
Optical fiber higher order mode technologies and their application within communication, sensing and bio imaging (HOMTech)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark,Sweden,Italy,Germany,Netherlands,Japan
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-10-01
End date: 2027-01-31
Duration (months): 52.0
Total project cost (EUR): 2807107.2
EU funding (EUR): 2807107.2
Participants: 17
Project status: SIGNED

Optical fibres supporting propagation of light in so-called higher order modes (HOMs) have gained major research interest in the last years. However, there are still quite a few obstacles to overcome before HOM fibres can be used for major commercial applications. In the HOMTech doctoral network, seven leading European universities, within the field of HOM fibres and their applications, join forces with one research institution and three European industrial partners and two world leading industrial research labs in the USA and Japan with the aim to significantly progress the field of HOM fibres and their applications. Five European countries are represented. Ten doctoral candidates (DC) will work in the network. Apart from the research and training at the host beneficiary, each DCs will also have two research secondments (both at least 3 months long) at another beneficiary or an associated partner. For DCs from academic partners, at least one of the secondments will be to an industrial partner. Five training schools in five different countries will be organized for the DCs through a joint effort between all beneficiaries. The research is organized in three work packages (WPs). WP1 on HOM applications within communication (both in optical fibres and in free space), WP2 on properties of HOMs, and WP3 on HOM applications within sensing. WP2 act both as support for WP1 and WP3, e.g., WP2 research essential non-linear properties of HOM fibres that is key in optical communication, but also applications of HOM for microscopy imaging. In WP1 both classical communication as well as quantum communication will be researched. It is the ambition that HOMTech will build a strong and lasting network not only between the DCs but also between the beneficiaries and associated partners. HOMTech aims at bringing European industry and academy in the forefront of HOM fibres and their application.

Keywords: optical fibres,communication,optical fibre sensing,higher order modes,few mode fibres,microscope imaging,nonlinear optics,mode division multiplexing,optical fibre characterization
Breathing Life into the New European Research Area and the ERA Policy Agenda Through Engaging Awareness-Raising Initiatives (INSPIRING ERA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Germany,Sweden,Slovakia,Poland,Austria,Lithuania
Call: Exploitation and valorisation of results relevant for the ERA Policy Agenda (HORIZON-WIDERA-2023-ERA-01, 2023)
Start date: 2023-12-01
End date: 2026-11-30
Duration (months): 36.0
Total project cost (EUR): 2166762.5
EU funding (EUR): 2166762.5
Participants: 6
Project status: SIGNED

The goal of INSPIRING ERA is to leverage and accelerate the valorisation of results from the ERA Policy Agenda 2022-2024 through a service-oriented hub that connects and supports Member State, Associated Countries and Stakeholders with regard to their joint implementation of the ERA actions in close collaboration with the European Commission. The project aims to create and support a culture of mutual learning, to build and strengthen a viable community of practice for ERA that thrives through from insights, and to maximize the broad uptake of valorisation of results stemming from the ERA Policy Agenda actions through the elaboration of recommendation and guidance for policy-makers.
Transmission Electron Microscopy Studies of Charge-Density Waves in YBa2Cu3Oy and ErTe3 (TEMCO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Understanding high-temperature superconductivity in cuprates is arguably the hardest problem in condensed matter. Active research in the pastten years has shown that a successful microscopic theory of superconductivity will need to describe other electronic phases that emerge alongside superconductivity. One of those electronic phases are charge-density waves (CDWs). We propose a novel approach to study CDWs and their competition with superconductivity down to the atomic scale using Transmission Electron Microscopy (TEM) and ultrafast TEM (UTEM) at cryogenic temperatures in the particularly clean cuprate YBa2Cu3Oy. These techniques are very sensitive to the periodic lattice distortion (PLD) that results from the coupling between the CDW and the lattice. Being able to study CDWs at the atomic scale, we will achieve a complete picture of the CDW properties in real-space that goes beyond what has been uncovered by X-ray diffraction and Nuclear Magnetic Resonance (NMR). Firstly, this will allow to study whether CDWs are correlated with disorder or vice versa. Secondly, by applying uniaxial strain we will enter the long-range CDW phase and investigate whether the PLD is truly incommensurate or whether repeated discommensurations shift the CDW wave vector away from a commensurate value, as has been suggested by NMR. Thirdly, using UTEM and photo-excitation within the superconducting state we will have the chance to observe the competition of CDWs with superconductivity in real-space at the femtosecond time scale. Before studying YBa2Cu3Oy, we will investigate a CDW model system, the transition metal trichalcogenide ErTe3. These two materials have a number of similarities. Both these studies will advance the understanding of charge-density waves. This novel approach will establish the study of charge ordering using electron microscopy at croygenic temperatures in cuprate superconductors.

Keywords: charge density waves,cuprates,transmission electron microscopy,transition metal trichalcogenides,high temperature superconductivity
Non-uniform programmable integrated photonic waveguide meshes (NU-MESH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-11-01
End date: 2025-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Programmable integrated photonics (PIP) is an emerging new paradigm that aims at designing common integrated optical hardware resource configurations, capable of implementing an unconstrained variety of functionalities by suitable programming. The work carried out within the Advanced Grant ERC-ADG-2016-741415 UMWPCHIP of which I was the Principal Investigator, allowed me to lay the foundation for the first technical stages of a novel revolutionary concept, the Field Programmable Photonic Gate Array (FPPGA), developed in the context of a Proof-of-concept Grant ERC-POC-2019-859927-FPPAs. Currently, the core of the processor is a uniform 2D programmable photonic waveguide mesh, formed by replicating hexagonal unit cells. This layout suffers from limited flexibility in the spectral period and sampling time values. The challenge is to develop and demonstrate solutions that overcome these limitations and which can be easily incorporated into existing mesh designs. In NP-Mesh I aim to demonstrate and validate the concept of non-periodic programmable photonic integrated waveguide meshes formed by embedding defect cells into the otherwise uniform 2D hexagonal mesh. Including defect cells solves the problem of spectral period limitation through the exploitation of the Vernier effect as well as the as the sampling time resolution limitation of the uniform waveguide mesh. My working roadmap will include: 1) carrying out the required research activities linked to the development of the proposed technical concepts, 2) validating them through outsourced chip fabrication in an external foundry followed by measurement and characterization experiments carried out in my lab at UPV, 3) generating the new intellectual property rights (IPRs) for the new results via patent writing and application and transferring the new IPR to the spinoff company iPronics, which I co-founded three years ago with the help of ERC-POC-2019-859927-FPPAs.
HISTORICISING THE PRIVATISATION OF HEALING KNOWLEDGE (PrivHealth)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: CLOSED

PrivHealth aims to establish the first history of the process of privatisation of healing knowledge. Combining methods from history of knowledge and tools from computational history, PrivHealth demonstrates how a legal framework that guaranteed that healing knowledge could be kept as a private asset arose from colonial exploitation and knowledge circulation between 1700 and 1900. The results of PrivHealth will provide a nuanced historical framework that will both shape academic historical debates and inform discussions over intellectual property rights in the medical and pharmaceutical fields at a societal level.

Keywords: history of knowledge,healing,medicine,privatisation,1700 1900,computational history
EU-AU PARTNERSHIP FOR RESILIENT, INCLUSIVE AND SAFE FOOD SYSTEMS FOR EVERYONE (UP-RISE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Belgium,Italy,France,Netherlands,Nigeria,Benin,Côte d'Ivoire,Kenya,South Africa
Call: EU-Africa Union – food safety (HORIZON-CL6-2023-FARM2FORK-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 5030905.0
EU funding (EUR): 5030905.0
Participants: 14
Project status: SIGNED

The UP-RISE EU-African Union (AU) project integrates food safety practices associated to mycotoxin contamination into all aspects of food production, distribution, marketing and consumption in the AU and provides tangible tools and strategies to enhance inclusive participation in the improved African Food Safety System (AFSS) at the local, national and regional level. UP-RISE activities are aligned with the current AU Food Safety Strategy for Africa, focusing on 3 regions of the AU with field work in 5 target member states (Benin, Côte d’Ivoire, Nigeria, Kenya, and South-Africa). UP-RISE assembles 5 building blocks for knowledge generation and implementation: 1) Roadmaps for a shared quality culture and possible integration of the informal sector in the AFSS; 2) Strengthening the food safety regulatory framework with focus on mycotoxins in both formal and informal sectors; 3) Early warning to prevent mycotoxin contamination and adapt to climate change; 4) Prevention of food losses and improving food safety by providing innovative microbiome-based solutions for mycotoxin reduction and nutritious food and 5) Co-creation, training and mentoring. UP-RISEs co-created solutions will be demonstrated on 5 representative fermented food product value chains based on maize, millet, sorghum or milk and will be implemented in 10 business cases of SMEs in the target AU member states. UP-RISE builds on strong synergies between all excelling consortium members combining social sciences with technological approaches and an outstanding network, which has been complemented with the Accelerator Platform comprising a.o. competent food safety authorities, farmers, consumers and trade organizations. UP-RISE guarantees sustainability through the creation of Training Hubs in each target member state, an AU-EU Microbial Biobank Network, early warning systems, a risk assessment toolkit and a food safety regulatory model.

Keywords: mycotoxins,fermentation,regulation,informal markets,early warning
Limiting West Nile Virus impact by novel vaccines and therapeutics approaches (LWNVIVAT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Spain,France,Germany,Denmark
Call: Pandemic preparedness and response: Immunogenicity of viral proteins of viruses with epidemic and pandemic potential (HORIZON-HLTH-2023-DISEASE-03, 2023)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 5772465.75
EU funding (EUR): 5772465.75
Participants: 8
Project status: SIGNED

West Nile virus (WNV) is considered one of the most widespread mosquito-borne viral disease in the world. While most of WNV infected individuals are asymptomatic, 1% of WNV-infected individuals develop a severe illness that affects the central nervous system, causing encephalitis or meningitis and eventually the death. The case-fatality rate notoriously increases in immunosuppressed individuals and in population over 60 years old (up to 30%) and, to date, there is no prophylaxis or treatment for this disease. Here, we aim to develop a safety prophylactic WNV vaccine that cover WNV diversity and protect elderly individuals by promoting the generation of potent and long-lasting neutralizing humoral and T cell responses, with limited or no cross-reactive activity against other flaviviruses. If success, the present proposal may guide the development of effective vaccines against other viruses, particularly flaviviruses. Methods: We will use outstanding computational tools to design novel Envelope-based immunogens that cover the global WNV genetic variability. Immunogens will be designed for eliciting highly-specific neutralizing humoral responses, with limited potential to mediate antibody-dependent enhancement (ADE) of infection or disease. In addition, we will also seek for T cell responses that work synergistically with antibodies to generate a long-lasting and polyfunctional protective anti-WNV immune response. Besides a classical and highly effective recombinant protein-based vaccine approach, we will explore novel and innovative strategies based on Virus Like Particles, and the use of antibodies as adjuvants, that may improve vaccine immunogenicity and efficacy. For immunogenicity analysis we have designed a complete set of assays that encompasses from in vitro testing, using human immune cells (tonsil and PBMCs) to in vivo evaluation using both young and old mice, and a complementary swine model.

Keywords: vaccines,antibodies,vlps,immunogens,adjuvants,immune response