Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Removing Technical Barriers to Biomethane STAndaRdisation Phase 2C (BIOSTAR2C)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Cluster 5 other
Destination: Other Climate, Energy and Mobility destinations
Action type: Coordination and support actions
Countries involved: Belgium,France
Call: Support to European Standardisation Organisations for biomethane injection in the grid in support of the implementation of the RED II as well as gas quality regulatory work (HORIZON-CL5-2022-REDII-IBA, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2999851.0
EU funding (EUR): 2999851.0
Participants: 2
Project status: SUSPENDED

This project marks the completion (Phase 2c) of a programme of work delivered in support of CEN and Technical Committee CEN/TC408 initiated by DG Ener, aimed at revision of the standards for and therefore removal of barriers to introduction of biomethane into gas networks and vehicles. By ensuring that the appropriate standards are fit for purpose at time of revision, the work will ensure that costs of biomethane injection are optimized, and there are no undue burdens on producers. This work is expected to enable growth of the biomethane industry and confidence that investments can be made in biomethane production and injection. It will therefore help to ensure the removal of barriers to achieving the RePowerEU target of 35BCM of biomethane by 2030 by aligning needs of producers, transporters and end users. The programme is therefore highly relevant in advancing regulatory work for greening the gas grid under the Green Deal. It is also relevant for implementing RED II with maximum impact. In cooperation with CEN TC 408, its stakeholder community and DG Energy, GERG has developed and has been delivering a workprogramme to address the removal of barriers identified which will enable standardization: Phase 1 - funded by GERG members to identify barriers SA/CEN/RESEARCH/475/2017-07 (2018-2019) – Phase 2a - experimental work on siloxanes, and a literature study on impacts of sulfur, impacts of oxygen, particularly related to underground storage and corrosion, and health impacts. SA/CEN/RESEARCH/475/2019-09 (2020-2022, Phase 2b, ongoing) – continued experimental work on siloxanes, commencement of experimental campaign on sulphur, and on oxygen impacts. Improving specific knowledge on biomethane at the European level, particularly in relation to impact of feedstocks, The project proposed here (2022-2024, Phase 2c) - Completion of the experimental and literature campaigns begun in Phase 2b to support the delivery by CEN TC 408 and update of the standards.

Keywords: biomethane standards redii repowereu barriers
Health Outcomes from Raised Urban Settings (HORUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Spain,Croatia,Netherlands
Call: Interventions in city environments to reduce risk of non-communicable disease (Global Alliance for Chronic Diseases - GACD) (HORIZON-HLTH-2023-DISEASE-03, 2023)
Start date: 2023-12-01
End date: 2026-11-30
Duration (months): 36.0
Total project cost (EUR): 3999250.0
EU funding (EUR): 3999250.0
Participants: 7
Project status: SIGNED

NCDs, especially diabetes and cardiovascular diseases (CVDs), are the leading causes of morbidity and mortality worldwide. CVDs kill more people globally than any other disease, accounting for 17.9 million deaths per year. Diabetes, on the other hand, accounts for 2 million deaths annually. These diseases have a greater impact on vulnerable populations. This increased prevalence among this population is related to a range of social and environmental factors, lifestyles, and the impact of behavioural determinants. Low-income communities, such as migrants or ethnic minorities, are still undertreated and unprotected by most of the healthcare systems with a lack of quality of care for NCDs and a lack of preventive measures specifically adapted for them. Thus, HORUS aims to tackle NCDs, especially diabetes and CVDs, in urban built environments among vulnerable populations, mainly low-income communities, migrants and ethnic minorities. In particular, it has a twofold objective. (1) First, to analyse and explore in depth the causal links between the characteristics of the urban built environment and the prevalence of NCD risk behaviours in an integrated, comprehensive and multi-approach manner. HORUS will focus on existing urban interventions modifying the physical-social and functional characteristics of the built environment with a significant impact on the prevalence of risk behaviours and, eventually, NCD outcomes. (2) And, secondly, to develop pilot interventions in three European countries –Spain, Croatia and The Netherlands– to promote behaviour change towards healthier lifestyles for empowering vulnerable populations, and to support citizens in making optimal use of the urban environment they live in while reducing NCD risk behaviours, especially those related to diabetes and CVDs.

Keywords: diabetes,cardiovascular diseases,vulnerable populations,urban environment,behavioural change
Developing a STEAM Roadmap for Science Education in Horizon Europe (Road-STEAMer)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Belgium,Greece,France,Malta,Netherlands,United Kingdom,Italy,Austria,Ukraine,Poland
Call: Developing a STE(A)M roadmap for Science Education in Horizon Europe (HORIZON-WIDERA-2021-ERA-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 1660625.0
EU funding (EUR): 1660625.0
Participants: 14
Project status: SIGNED

The overall aim of the proposed project is to develop a STEAM roadmap for science education in Horizon Europe, i.e. a plan of actions that will provide guidance to EU's key funding programme for research and innovation on how to encourage more interest in STEM through the use of artistic approaches involving creative thinking and applied arts (the "A" in "STEAM"). The consortium aims to provide Europe with this roadmap, through: 1) Collaboration and co-creation with the stakeholder communities of science education, research, innovation and creativity, through intensive exchange, dialogue and mutual learning among them which will produce better knowledge and shared understandings of the relevant opportunities, challenges and needs; 2) A bottom-up approach emphasizing educational practice and practitioners' agency rather than high-level conceptualizations of STEAM and generic top-down plans (in reality often just vague statements of intention) for its adoption in science education; and 3) A specific focus on ways to leverage the power of STEAM approaches, as manifested through exemplary cases and best practices, in order to enable a bridging of open science and open schooling mentalities and practices, which can catalyse an increased impact for science education as a crucial tool for addressing Europe?s current scientific and societal challenges. The originality of Road-STEAMer resides in its overall approach to the development of the STEAM roadmap that will triangulate the knowledge gained from the stakeholder engagement and the analysis of the STEAM practices with the knowledge produced from the analysis of the current educational policies, contexts and frameworks.

Keywords: open science,open schooling,horizon europe,arts
Antiviral Therapeutics for Rapid Response Against Pandemic Infectious Diseases (AVITHRAPID)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Netherlands,France,Latvia,Czechia,Switzerland,Portugal
Call: Pandemic preparedness and response: Broad spectrum anti-viral therapeutics for infectious diseases with epidemic potential (HORIZON-HLTH-2023-DISEASE-03, 2023)
Start date: 2024-01-01
End date: 2028-06-30
Duration (months): 54.0
Total project cost (EUR): 7459253.75
EU funding (EUR): 7459253.75
Participants: 20
Project status: SIGNED

The European Consortium "Antiviral Therapeutics for Rapid Response Against Pandemic Infectious Diseases" (AVITHRAPID) aims to support the search for novel broad-spectrum antiviral compounds by advancing multiple approaches. Building on a pre-existing set of bioactive small molecules, which are at least at the validated hit level, AVITHRAPID strives for the development of pre-clinical candidates targeting several viruses. This will be achieved by combining the relevant expertise for pre-clinical drug discovery, including molecular modeling, biochemical and cell-based assays, X-ray crystallography, medicinal chemistry, biophysical binding studies, ADMETox profiling, in vitro and in vivo PK, as well as animal disease models. In addition, the consortium aims to conduct a Phase 2a clinical trial for a small molecule developed against Zika virus. Moreover, the consortium aims to identify and validate further viral targets and thereby contribute to the search for novel antiviral targets. As a consequence of the activities in AVITHRAPID, an early-stage drug discovery pipeline will be established that can be used to rapidly identify and develop novel antiviral compounds against emerging diseases.
Genomic applications for laboratory Diagnostics supported by Artificial Intelligence (GenDAI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Ireland,Italy
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 1311000.0
EU funding (EUR): 1145400.0
Participants: 6
Project status: SIGNED

GenDAI will leverage metagenomic potential to deliver powerful diagnostic results facilitating the development of Personalized Medicine, addressing assay research and development as well as productive clinical diagnostics in a comprehensive way by creating a highly innovative medical diagnostics platform that supports microbiome profiling with novel biomarkers using Artificial Intelligence (AI). This innovative platform will allow clinicians to assess and monitor patients while complying with strict regulatory requirements of laboratory diagnostics. Ultimately, GenDAI will contribute to accelerate conversion of innovative ideas and technology solutions into breakthroughs in medical analyses services. Delivery of GenDAI tangible outputs will be driven by the following Research and Innovation Objectives: a) Create new metagenomic datasets containing microbiome samples from stool of patients under informed consent suffering from inflammatory bowel disease (IBD); b) Develop and integrate the GenDAI Diagnostics Workflow, focusing on implementing a fully automated data processing pipeline; c);Provide a robust, cloud-based foundation for the development of the platform that integrates advanced data management and knowledge infrastructure focusing on security, reproducibility and long-term archiving (GenDAI Safe); d) Develop and improve AI methods to identify relevant biomarkers and classify corresponding metagenomic sequences in order to characterise microbiome profiles to provide a personalised diagnostic result of patients’ state of health (GenDAI Discovery); e) Deliver innovative visual user interfaces and interactive clinical reporting (GenDAI Interactive Reporting) and f) Deliver the marketable, regulatory compliant GenDAI technology and tool suite.

Keywords: cloud computing software development,advanced visualisation,data management,persistent identifiers
Impacts of biodiversity loss on food webs during the Upper Palaeolithic in the Cantabrian Region. (FOOD-WEBS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom,Norway
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-02
End date: 2028-01-01
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 2
Project status: SIGNED

During the Upper Palaeolithic, Europe witnessed major climatic changes, the extinction of mammal species, and substantial transformations in human demography and culture. In the Cantabrian Region, a climate refuge during colder phases, human populations grew exponentially, marking the onset of resource overexploitation. By integrating cutting-edge paleoclimate reconstructions, extensive archaeo-paleontological data, ancient environmental DNA and trophic network models, FOOD-WEBS will test whether, and to what extent, the loss of biodiversity affected: a) the human carrying capacity, and b) the vulnerability of human populations to climate changes. The Evolutionary Ecology Group, led by Prof. Manica and renowned for ecological modelling, will provide training in machine learning techniques to reconstruct trophic interactions between species. In addition, training in ancient DNA metabarcoding will be acquired during a secondment in Prof. Alsos’s Ancient DNA lab. Using climate-induced biomass fluctuations, we will estimate the abundance of each species and compute, for the first time, energy fluxes along trophic links. This will enable the first quantitative assessment of human resilience to climate change and biodiversity loss in our deep past. The training and research offered by this MSCA will position me as an expert in past trophic networks and computational archaeology. FOOD-WEBS will build a new reference framework to assess the relationship between climate change, biodiversity loss, and human population dynamics in Prehistory.

Keywords: paleoecology,modelling,computational archaeology,environment
Isotope geochemistry to Water pool conservatIon in viNEyards (IsWINE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,New Zealand
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-15
End date: 2027-08-14
Duration (months): 36.0
Total project cost (EUR): 257235.36
EU funding (EUR): 257235.36
Participants: 3
Project status: SIGNED

In the EU, changing precipitation patterns pose challenges to the wine sector, urging it to adapt to shifting climate conditions. IsWINE aims to quantify the effect of land management practices on the water pool of vineyards, providing valuable information on climate change adaptation. As European winegrowers increasingly recognize the urgency of harmonizing sustainability practices with economic viability and grape quality, New Zealand vineyards stand out as role models, demonstrating their long-standing commitment to sustainability. At the intersection of environmental and agricultural sciences, IsWINE will establish two pilots, one in Northern Spain and another in New Zealand, to empirically test the correlation between different land management practices and soil moisture, grapevine water uptake, and water use efficiency of grapevines using isotope geochemistry. This approach will allow meaningful insights into vineyard resilience and cross-learning between the two regions. EU wine stakeholders will participate in defining adaptive management measures resulting from the pilots, thereby delivering tangible solutions aligned with the sector. By generating actionable knowledge, IsWINE can equip European vineyards with adaptation measures to balance environmental stewardship and agricultural productivity. These efforts align with the European Green Deal and the Common Agricultural Policy, supporting many strategies and two EU Missions of the Member States. IsWINE will be hosted by three highly qualified institutions. The outgoing phase (24 months) will take place at the University of Auckland under the guidance of Asso. Prof. Luitgard Schwendenmann, the return phase (12 months) at the Neiker Technology Center under the supervision of Dr. Ana Aizpurua, and a secondment (3 months) will take place at the University of Barcelona under the guidance of Dr. Adrià Barbeta.

Keywords: vineyard management practices,water pool,climate change adaptation
The Role of novel PKC Kinases in Integrin Activation (nPKCInAction)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 1
Project status: CLOSED

Integrins represent a family of cell adhesion receptors mediating cell interaction with the extracellular matrix ligands. Their ligand-binding activity is tightly regulated and, when defective, gives rise to thrombosis or inflammation and contributes to cancer progression. To date, the key steps of integrin activation in response to both extracellular and intracellular signals are well described, however, the counteracting processes resulting in receptor inactivation remain incompletely understood. The host laboratory has pioneered research in this area by screening to identify integrin inactivating proteins involved in neuronal disorders, cell migration and cancer. Although the novel subfamily of protein kinase C (nPKC) has emerged from these screens as putative integrin inhibitors, the role of these kinases in regulation of integrin-mediated signalling remains to be investigated. Benefiting from my strong methodological proficiency in protein kinase research and the host laboratory's extensive expertise in integrin biology in cancer, I aim to address the role of nPKCs in regulation of integrin activation from both mechanistic and pre-clinical points of view. I expect to identify new cancer relevant signalling nodes by executing mechanistic in vitro studies with specifically engineered kinase mutants, state-of-the art cancer cell biology and imaging, followed by in vivo pre-clinical cancer studies in cancer models and patient sample cohorts. The result of this innovative and interdisciplinary project will represent a valuable basis for potential design of drug targeting strategy and therapeutic intervention not only for treatment of cancer, but also of other diseases where nPKCs and integrins are implicated.

Keywords: integrin regulation,protein kinase c,cancer signalling,cell migration,metastasis,phosphorylation,protein protein interaction
How salty was the Mediterranean Outflow Water? (HowMOW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-12-15
End date: 2025-12-14
Duration (months): 24.0
Total project cost (EUR): 172618.56
EU funding (EUR): 172618.56
Participants: 1
Project status: SIGNED

Heat and salt are major components of the thermohaline circulation of the global conveyor belt as they regulate the masses of water bodies and and hence ocean-climate dynamics. The thermohaline circulation (THC) has played a significant role in the past climate extremes such as the onset of the Northern Hemisphere Glaciation. Although the temperature component of the THC can be extracted applying various methods such as foraminiferal magnesium/calcium thermometry and alkenone thermometry, salinity information of past seawaters is still among the unknowns in paleoclimate studies due to the lack of a direct paleosalinity proxy. Thus the role of one important salt contributor, the Mediterranean Outflow Water, to the deeper levels of the THC during major climate shifts in the geological record is scarcely documented. To that extent, this research proposal aims at establishing and exploring a new proxy that will allow to extract information on past salinity changes in seawater from deep-sea benthic foraminifers. As second step, I will investigate the role of the Mediterranean Outflow Water in the THC and the shift in ocean-climate dynamics during a well-documented major climate shift, i.e., the Early-Middle Pleistocene Transition (1.2-0.7 Million years ago), when the 41-kyr glacial-interglacial cycles were replaced with 100-kyr abrupt cycles. Execution of this project will allow me to enhance my scientific portfolio by learning a new technical instrument, joining a new research group in an internationally fast-growing research center, having the opportunity to manage my own research budget, and benefitting from the experience of the chosen supervisor, which are positive impacts for an early career scientist in becoming an established independent researcher.

Keywords: foraminifers,trace elements,mediterranean sea,empt,paleosalinity