Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Rewriting the End of Cuneiform Culture (RECC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 1997950.0
EU funding (EUR): 1997950.0
Participants: 1
Project status: SIGNED

In the prevailing view, cuneiform script survived until the first century CE because it was the only way to write the most enduring Mesopotamian science, astronomy. This view, however, is skewed by the nature of the data: while astronomical texts are easy to date, the vast majority of non-astronomical tablets cannot be dated and are overlooked in histories of the period. Yet, the vitality of cuneiform in its terminal phase suggests that a wealth of late literary and scholarly tablets awaits the development of new dating methods. The aim of the Rewriting the End of Cuneiform Culture (RECC) project is to explain why cuneiform survived long after the great Mesopotamian centers had lost their prominence and become provinces within vast empires. The hypothesis posits that the survival and flourishing of cuneiform is a reaction to these changes, an attempt to defend the native tradition against cosmopolitan cultures. With their labored writings, Babylonian scholars endeavored to show that their legacy still had the power to speak to their own world. The project has three Research Objectives: • To grasp the extent of the textual production of the late period and the network of scribal families responsible for it. • To chart the development of cuneiform script by means of a pioneering Machine Learning-powered tool (CuneiDate) that enables, for the first time, the inferred dating of undated tablets. • To rewrite the end of cuneiform civilization by explaining the reasons for the continued use of cuneiform. This pathbreaking method promises to revolutionize cuneiform studies and other disciplines that study manuscript cultures by providing historical context to thousands of unmoored documents. The recovery of these contexts will disclose how the Babylonians coped with the loss of significance of their millennia-old traditions and offer insights for contemporary cultures experiencing “cultural anxiety” as they interact with more dominant cultures in a globalized world.

Keywords: cuneiform,mesopotamia,hellenistic babylonia,assyriology,digital paleography
Improving MicroPollutants Analysis and Controlling of Terrestrial and Aquatic Systems (IMPACTAS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Austria
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2022-12-01
End date: 2025-05-31
Duration (months): 30.0
Total project cost (EUR): 226441.2
EU funding (EUR): 226441.2
Participants: 2
Project status: CLOSED

Degradation of plastics is a sequence of chemical and physical changes reducing their molecular weight and mechanical integrity of the polymer and leads to formation of microplastics (MPs). Negative effect of the MPs on the environment is not only physical, but also chemical due to their ability to adsorb and accumulate many persistent organic pollutants The role of MPs as a vector of the contamination is newly formed phenomenon and could fundamentally top off the role of MPs in the ecological systems. Only limited number of scientific papers and research are currently available and published, thus IMPACTAS project aims to change it. University of Las Palmas de Gran Canaria provides unique opportunity to study micropollutants-microplastics topic in terms of islands location, extensive tourism industry, protected natural parks, excellent infrastructure and knowledge of Environmental Analytical Chemistry research group belonging to Institute for Environmental Studies and Natural Resources. Project will focus at few objectives: - Development of analytical methodologies and strategies for the determination of organic pollutants adsorbed on MPs; - spatial and temporal monitoring of micropollutants - microplastics in different environmental compartments and; - environmental risk assessment of micro-pollutants in different natural ecosystems. Objectives of the project are multidisciplinary including combination of analytical chemistry, statistics, biology and environmental sciences. IMPACTAS implies international research visits and placement of the researcher for further knowledge implementation. Expected results have potential to provide state of the art solutions for micropollutants monitoring and control in different environmental and biology systems around Canary Islands which could be transferred across research groups within EU countries. This project is in line with the EU Strategy for Plastics in a Circular Economy and Blue Growth strategy of the European Union

Keywords: uhplc,mass spectrometry,method development,ultrasound extraction,risk assessment,high resolution accurate mass spectrometry,environmental monitoring,aquatic systems,marine life
Early Interception of Inflammatory-mediated Type 2 Diabetes (INTERCEPT-T2D)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: France,Germany,Italy,Belgium,Netherlands,Sweden,Switzerland
Call: Personalised blueprint of chronic inflammation in health-to-disease transition (HORIZON-HLTH-2022-STAYHLTH-02, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 8689221.5
EU funding (EUR): 8689221.5
Participants: 14
Project status: SIGNED

The overall concept of INTERCEPT-T2D is to establish whether an inflammatory-mediated profile contributes to the onset of Type 2 Diabetes (T2D) complications, thus enabling the identification of patients most at risk of complications and the design of personalized prevention measures. T2D is a heterogeneous disease, which is an obstacle to the delivery of an optimal tailored treatment. Consequently, patients’ individual trajectories of progressive hyperglycemia and risk of chronic complications are so far difficult to predict. In this context, onset of diabetic complications represents the most important transitional phase of T2D development toward premature disability and mortality. Chronic systemic inflammation has been suggested to be a major contributor to the onset and progression of T2D complications. INTERCEPT-T2D will bring a new and clinically relevant dimension in T2D care considering at diagnosis inflammatory parameters that are of importance for the transition to T2D-related complications. The combination of state-of-the-art genomics and cell-biology technologies with targeted clinical interventions should lead to potent patients’ stratification. It should allow the identification and prognosis of a novel class or subclass of patients characterized by an “Inflammatory-mediated T2D” endotype. The project has access to the best-documented longitudinal human European cohorts of patients with T2D, with reliable clinical and biological data allowing to trace the transition and evolution towards organ complications. This, added to the exploitation of an extensive health data warehouse, will enable us to establish the inflammatory trajectory of citizens with T2D from diagnosis to the development of complications. To explore the ability to prevent the transition phase of T2D towards organ complications, INTERCEPT-T2D will conduct a phase II clinical trial with an anti-inflammatory therapy targeting NLRP3 Inflammasome activity in patients with T2D.

Keywords: type 2 diabetes,diabetes complications,chronic inflammation,nlrp3 inflammasome,anti inflammatory therapy,phase 2 clinical trial
Efficient algorithmic methods for preparing large resource states with neutral atoms (RydbergAtomArrayTech)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 230184.72
EU funding (EUR): 230184.72
Participants: 1
Project status: SIGNED

The proposed research plan sets itself the main goal of preparing useful large resource states using quantum systems consisting of neutral atoms. These non-classical resource states are at the core of the full range of quantum technologies, from quantum metrology to quantum error-correction and communications. This main objective will be achieved through the synthesis of two novel techniques developed in distant research subfields, both under the umbrella of Quantum optics and information. On the one hand, we leverage the unique versatility of neutral atom systems, which has allowed these systems to emerge as a leading platform for realizing quantum technologies. On the other hand, we bring in the insights that were recently developed in the field of Quantum Algorithms, which has improved the asymptotic complexity of the most important fault-tolerant algorithms, including Hamiltonian simulation and search algorithms. The collection of these algorithmic insights are called Quantum Signal Processing (QSP). Our approach is novel from two perspectives. First, we will propose QSP as a method for controlling near-term quantum systems and preparing resource states, in contrast to its conventional application in implementing fault-tolerant quantum algorithms. Second, we will develop techniques to make implementations of QSP-based state preparation and communication protocols feasible in near-term systems. The participant's expertise in quantum information and the host's expertise in atomic physics perfectly complement one another to render this ambitious objective possible. The proposed project is embracing an ambitious co-design approach, where the quantum software and the concrete hardware platform are developed in synchrony. The co-design approach is a requirement for developing quantum technologies in near- and intermediate-term, and a natural next step for combining the decades of theoretical and practical insights from designing quantum algorithms and devices.

Keywords: neutral atoms,quantum control theory,quantum signal processing,resource state preparation
Learning to synthesize interactive 3D models (NEURi3D)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Greece
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Visualizing our surroundings and imagination has been an integral part of human history. In today's era, we have the privilege to immerse in 3D digital environments and interact with virtual objects and characters. However, creating digital representations of environments (i.e., 3D models) often requires excessive amount of manual effort and time even for trained 3D artists. Over the recent years, there have been remarkable advances in deep learning methods that attempt to reconstruct 3D models from real-world data captured in images or scans. However, we are still far from automatically producing 3D models usable in interactive 3D environments and simulations i.e., the resulting reconstructed 3D models lack controllers and metadata related to their articulation structure, possible motions, and interaction with other objects or agents. Automating the synthesis of interactive 3D models is crucial for several applications, such as (a) virtual and mixed reality environments where objects and characters are not static, but instead move and interact with each other, (b) automating animation pipelines, (c) training robots for object interaction in simulated environments, (d) 3D printing of functional objects, (e) digital entertainment. In this project, we will answer the question: "how can we automate the generation of interactive 3D models of objects and characters?". Our project will include the following thrusts: (1) We will design deep architectures that automatically infer motion controllers and interaction-related metadata for input 3D models, effectively making them interactive. (2) We will develop learning methods that replace dynamic real-world objects and characters captured in scans and video with high-quality, interactive, and animated 3D models as digital representatives. (3) We will develop generative models that synthesize interactive 3D objects and characters automatically, and further help reconstructing them from scans and video more faithfully.

Keywords: 3d modeling,3d deep learning,animation,reconstruction,generative models
Boosting the uptake of circular integrated solutions in construction value chains (CIRC-BOOST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Innovation actions
Countries involved: Spain,France,Serbia,Czechia,Greece,Italy,Germany,Norway
Call: Integrated solutions for circularity in buildings and the construction sector (HORIZON-CL6-2022-CIRCBIO-02-two-stage, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 9143250.0
EU funding (EUR): 7890862.5
Participants: 28
Project status: SIGNED

In order to upscale circular solutions in buildings and the construction sector in general, a concentrated research effort involving multiple actors and stakeholders is needed. This includes the development and deployment of both digital and technical solutions in building urban material databanks, digital twins, as well as demolition, decontamination and recycling and reuse of waste materials. With this in mind, the Circ-Boost project proposes to become a focal point and interaction node for different emerging technologies to foster circularity in buildings and the construction sector. The project's core consists of five pilot projects, deployed in different European regions, highlighting and demonstrating at large scale novel and integrated solutions for demolition, construction waste processing, management, and valorisation in new products. Transversal activities of digitalization will allow collaboration between the pilot projects and more efficient use of digital tools and platforms. Targeted activities are envisioned for boosting and maximising the pilot projects' commercial and business potential through effective exploitation measures. Furthermore, in order to ensure that the solutions demonstrated will actually be adopted by the industry, the project will support construction and design companies in educating and training their workforce to optimally use the new technologies as part of training activities. The Circ-Boost project will also leverage the partners' existing regional and international networks and connect with new networks, initiatives, and projects to disseminate and compare project results with a wide audience of construction stakeholders increasing the overall uptake potential of circular solutions. Finally, tailor-made communication and dissemination measures will further support the dissemination of project results with policy makers, and European-wide construction industry, as well as the promotion of the project's success.
Vibrational Micro-robots in Viscoelastic Biological Tissues (VIBEBOT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1499728.0
EU funding (EUR): 1499728.0
Participants: 3
Project status: SIGNED

Wireless micro-robots hold great potential for minimally-invasive medicine, since they may allow for targeted drug delivery, in vivo sensing, stimulation, and even new surgical procedures. However, the biggest hurdle for biomedical applications is the penetration of real biological media, for instance, mucus, vitreous, blood clots and tumour tissues. Most current micro-/nano-robots can propel in water, however, the same propulsion mechanisms do not readily transfer to viscoelastic biological media. One major bottleneck is that it is not possible to exert enough force for propulsion in a system that could one day also accommodate a human. The overall goal of this proposal is to develop vibrational microdevices that can actively propel and wirelessly sense in viscoelastic biological tissues. The excited mechanical vibration is coupled with the frequency-dependent fluidic rheology to increase the energy release rate, to reduce the penetration force needed for tissue rupture, and thus to facilitate an easier penetration of the tissues. We will investigate the fundamental mechanisms of propulsion at low Reynolds number in viscoelastic materials. The microrheology of the biological fluids will be measured and modelled, and it will allow us to optimize the shape and gait of the micro-robot to exploit the complex rheological properties of biological tissues and generate propulsion. The proposed work will also advance three-dimensional fabrication technologies for asymmetric micro-/nanostructures as key elements to interact with tissues to facilitate efficient locomotion. We will also develop novel sensing methods for in vivo sensing and localization of the microdevices. Our research will lead to a new class of micro-robots - the VIBEBOTS that will be able to actively penetrate real tissues, and open up outstanding opportunities for useful biomedical applications.

Keywords: bio rheology,mechanical vibrations,micro robotics,micro propulsion,microdevices,biomedical engineering
Next-generation red cell analysers for blood-banking, transfusion medicine, and haematological diagnosis (BLOODSPEED)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom,Poland
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-10-01
End date: 2026-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: SIGNED

Tissue O2 delivery is essential for life and rate-limiting for activities. Its maintenance is paramount in medical conditions ranging from critical care to anaemia, and a common corrective intervention is blood transfusion, drawing an annual demand of >20 units/1000 people. Blood tests are routinely performed (2/capita/year in Europe) to measure surrogates of O2-carrying capacity, such as haemoglobin content, driving a global market worth €10B. However, current diagnostics cannot measure the speed of O2 release from red blood cells (RBCs), a parameter as important in determining tissue oxygenation as O2-carrying capacity and particularly labile in haematological disease and blood storage. To address this unmet need, we developed single-cell oxygen saturation imaging, a method for tracking O2 release from individual RBCs. We demonstrated how O2-unloading depends critically on the shape and metabolic state of RBCs, providing a gauge of the blood’s physiological quality. Notably, our method described slower O2 unloading in spherocytic anaemias and in banked blood units. To verify significance, we showed how impaired O2 release from stored RBCs reduces oxygenation and respiration in perfused human kidneys. End-users of our technology are blood-banks (quality control, recipient-donor matching, guiding improvements in materials and methods) and clinicians (novel haematological traits, transfusion, transplant medicine). However, further data are required to re-affirm the medical utility and market for our novel parameter. Teaming with engineers and industry, this project will design and assemble three benchtop prototypes of our device for proof-of-concept testing in a blood bank (UK’s NHSBT), intensive care (Great Ormond St Hospital), and haematological research (Peru). Positive experience will make a compelling case for measuring O2-handling. Our ambition is to produce a next-generation haematology analyser as a spin-out, or for acquisition by a major commercial partner.