Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Extreme Ultraviolet Ptychographic Microscopy (XUVPM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

This project “Extreme ultraviolet ptychographic microscopy” (XUVPM) aims at improving the robustness and resolution of multispectral extreme ultraviolet (XUV) ptychography by realizing novel types of high divergence structured illumination in XUV spectral range. In this microscope, two-color generation of high-order harmonics from an industrial grade femtosecond laser will be employed to create structured illumination with controllable degree of orbital angular momentum (OAM) to be combined with ptychography. The high-repetition rate and high-average power femtosecond laser source will be temporally compressed with pulse post-compression and then split into two beams, the weaker beam is used to generate the second harmonic in a nonlinear crystal. This forms a two-color interferometer where each arm contains a spatial light modulator (SLM) to individually imprint OAM into each beam. Both beams are directed and focused into a noble gas jet in a non-collinear scheme to obtain high-order harmonics with controllable OAM. The OAM-HHG beam consisting of multiple harmonic orders is focused onto the sample by two toroidal mirrors in Wolter configuration. The sample is scanned transversely and at each scan position a CCD camera records the diffraction pattern. The generated XUV radiation will be optimized for its divergence and spatial properties, where the OAM can be controlled by the settings of the individual SLMs for the two generating colors. The fundamental research on the described illumination technique will offer a chance to investigate the resolution limit of tabletop XUV microscopy, which further can address imaging science challenges associated with, e.g., the fabrication, synthesis, and integration of next-generation quantum and semiconductor devices. The work is supported by two experienced supervisors from complementary fields, covering the whole spectrum of the proposed project.

Keywords: high harmonic generation,extreme ultraviolet,orbital angular momentum,ptychography,structured illumination
Emergent soil, plant and food onsite digital services on chemical and biological contaminants (E-SPFdigit)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Innovation actions
Countries involved: Greece,Cyprus,Spain,France,Portugal,Ireland,Netherlands,Serbia,Italy
Call: Onsite digital technologies to monitor nutrients and chemical or biological stressors in soil and plants with relevance for food safety and nutrition (HORIZON-MISS-2023-SOIL-01, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 5652477.5
EU funding (EUR): 5033127.5
Participants: 18
Project status: SIGNED

E-SPFdigit will bring novel onsite digital tools already at TRL5 under systemic innovation, which will be further deployed, upscaled, field-tested and demonstrated to TRL7-8, in viticulture and horticulture applications in Greece and Spain in soil-contaminated areas (located near mines, offensive industries, highways, floodwaters). E-SPFdigit brings novel developed: i) MIP-based electrochemical sensors coupled with SPME for on-site monitoring and analysis of dedicated to PFAS targeted molecules, ii) Multiplex organic Surface Plasmon Resonance optical biosensors for onsite pesticides residues monitoring and analysis, iii) IDE-based electrochemical sensors for onsite detection and quantification of heavy metals & micronutrients, and iv) UVC LED -based nutrient analysers for soil water content in-situ and real time monitoring. The AI-driven onsite digital tools will be model calibrated using machine learning algorithms to improve error distribution of a predictive model, ensuring reliability. Also, E-SPFdigit brings an edge-based remote sensing framework via a robust autonomous mobile robot self-navigating and a heavy-duty unmanned aerial vehicle for in-field detection of soil parameters regarding the aforementioned chemical and biological stressors. Finally, to predict pesticide and fertiliser and other chemical contaminants impacts on crop-soil-microbiome nexus, the project will use on-field real-time digital ground sensors combined with Earth Observation data and causal machine learning. All the onsite digital tools will be interconnected with a Decision Support Systems with blockchain and cybersecurity mechanisms enabling informed decisions and automated decision making for IPM and INM, enhanced with automated decision making for immediate soil management practices.

Keywords: onsite digital tools,food safety,pesticides,pfas,heavy metals,nutrients,soil food nexus,engss,robots,uav fungal diseases,living labs,floodwaters
Catalysis for Cancer Treatment. (Cat4CanCenter)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC Synergy Grants (ERC-2023-SyG, 2023)
Start date: 2024-01-01
End date: 2029-12-31
Duration (months): 72.0
Total project cost (EUR): 10603994.0
EU funding (EUR): 10603994.0
Participants: 3
Project status: SIGNED

The increased incidence and mortality of tumors that do not respond to standard of care or other targeted therapies is a major challenge in clinical management of these cancer patients. In order to provide innovative therapeutic avenues for treatment refractory patients, it is urgent to develop novel mechanisms of anticancer drugs mode of action that will overcome the drawbacks of current therapies. In Cat4CanCenter, we will merge the research fields of metal-based catalysis for drug development and innovative delivery routes with cancer biology and immunology, applied to one of the deadliest cancers, glioblastoma (GBM), a fatal primary brain tumor for which no curing therapy exists, due to its location within the brain parenchyma and complex tumor microenvironment. Many potential drugs failed in the clinic due to their inherent toxicity and off-target side-effects, which add up to the challenges in reaching the protected brain site. Recently, innovative catalyst design enabled synthetic transformations in the presence of biological molecules. In Cat4CanCenter we will develop four innovative approaches to treat GBM. This new methodology requires the design of cage protected catalysts that will be delivered to targeted cell types using advanced lipid nanoparticle technology. Next, the catalysts will convert nontoxic prodrugs into active drugs within the GBM bulk. Our groundbreaking strategy aims for successful therapies to treat glioblastoma, by developing complementary approaches to therapeutically tackle the complexity of this disease. The new strategies, catalysts and prodrIn this project we explore a new avenue to treat glioblastoma, which is the most difficult cancer to target. In a collaborative program we develop biomimetic transition metal catalysts (key expertise 1) that will be delivered using smart strategies such as lipid nanoparticles (key expertise 2) to generate cancer drug in vivo. The glioblastoma biology will be studies in detail (key expertise 3).

Keywords: supramolecular cage catalysis transition metal catalysis glioblastoma tumor micro environment
Surgify Safety Burrs for safer bone surgery (SSB2)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Finland
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 3484825.0
EU funding (EUR): 2439377.5
Participants: 1
Project status: CLOSED

6 out of 15 top surgical procedures include bone cutting, which are performed using surgical power tools such as high-speed drills. These drills are widely used in neurosurgery, otology (ear), and spinal procedures, which include some of the most demanding surgical bone operations. However, 30% of bone drilling surgeries can lead to severe soft tissue injury. Missing a target by only millimetres or applying slightly too much force can lead to severe complications threatening patients’ life. The revolutionary Surgify Safety Burr enables surgeons to cut bone accurately and efficiently without compromising the safety of important soft structures. Thanks to the scalable technology, the safety feature can be customized for wide range of applications e.g. orthopaedics, pediatrics or even robotics-assisted surgery. During the EIC project Surgify Safety Burr product platform will be designed, developed and commercialized to allow safer surgeries for everyone.

Keywords: robotics for healthcare,surgical bone drilling,soft tissue protection,sensory product,micromechanical engineering,high speed drill,orthopaedics,surgical safety burr
Decarbonized Steel Production with Novel Processes (ZEROSTEEL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Clean Steel (co-programmed)
Countries involved: Germany,France,Denmark,Greece,Austria,Belgium,Finland,Cyprus,Türkiye,Brazil
Call: CO2-neutral steel production with hydrogen, secondary carbon carriers and electricity OR innovative steel applications for low CO2 emissions (Clean Steel Partnership) (RIA) (HORIZON-CL4-2024-TWIN-TRANSITION-01, 2024)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 4998951.25
EU funding (EUR): 4998931.25
Participants: 19
Project status: SIGNED

The ZEROSTEEL project aims at reducing the CO2 emissions in the steel production applying novel technologies, integrating green hydrogen, coming from local networks and electrolyzers, for the direct reduction of the iron ore. In particular, four novel direct reduction processes will be applied which will be integrated from hydrogen or/and renewables, namely (a) the Circored Fluidized Bed (CFB), (b) the rotary kiln direct reduction, (c) the hydrogen plasma smelting reduction and (d) the molten oxide electrolysis. Additionally, the possibility of utilizing biomass to produce green hydrogen will be also investigated, aiming at the valorisation of biobased residues as well as the development of a Digital Twin for AI-based steel quality monitoring. Biochars will be also be produced from the biomass utilization which will be applied as alternatives foaming agents at the EAF process. At last novel hydrogen- based hydrogen-based technolgiestechnologies will be integrated in the forming and shaping of the steel closing the loop of the zero emissions technologies for the steel production. The above-mentioned activities will be completed by a detailed life cycle and environmental assessments along with a clear business case for the exploitation of project’s activities and the corresponding business plan.

Keywords: hydrogen,biomass,green steel
dealii-X: an Exascale Framework for Digital Twins of the Human Body (dealii-X)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Research and Innovation actions
Partnership: EUROHPC (JU-JTI)
Countries involved: Germany,Italy,Belgium,France
Call: Call on Centres Of Excellence For Exascale HPC Applications (HORIZON-EUROHPC-JU-2023-COE-03, 2023)
Start date: 2024-10-01
End date: 2026-12-31
Duration (months): 27.0
Total project cost (EUR): 3939780.0
EU funding (EUR): 1969890.02
Participants: 16
Project status: SIGNED

"dealii-X: an Exascale Framework for Digital Twins of the Human Body" is a pioneering project aimed at developing a scalable, high-performance computational platform using the deal.II library to create accurate digital twins of human organs, with emphasis on the human brain. This framework will leverage exascale computing capabilities and existing lighthouse applications to simulate complex biological processes in real-time, aiding in personalized medicine and advancing the diagnosis and treatment strategies of neurological disorders. The computational complexity to solve the underlying mathematical models has previously prevented the simulation knowledge from being translated into clinical practice. By integrating cutting-edge HPC technologies with multiphysics and multidisciplinary approaches, dealii-X will deliver unprecedented computational efficiency and fidelity in biological modeling. The project represents a significant leap toward the future of medical diagnostics and treatment planning, offering a robust tool for researchers and clinicians alike.

Keywords: finite element method,computational fluid dynamics,computational structure mechanics,matrix free methods,multiphysics problems,coupling algorithms
Learning from nature: Microbiome training towards improving agricultural sustainability (MicroTRIAS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

A major challenge for mankind in the age of climate change is to feed the increasing human population in a sustainable manner. Currently, more than one third of crop yields are lost due to abiotic and biotic stresses, such as drought, salinity, pests and diseases. To minimize this yield gap and to simultaneously reduce the environmental impact of current agricultural practices, future crop production needs to be achieved with reduced input of fertilizers and pesticides. These challenges have increased the awareness of plant microbiomes bearing a hidden untapped potential for crop productivity and resilience that we must learn to use. Recently, more and more microbial products are tested in agriculture but often they are based on one or a few bacteria inoculants. However, the performance and efficacy of these products can be affected by many factors such as, soil type, temperature, humidity and the composition of the native microbiomes. The aim of the microTRIAS project is to unfold the potential of microbiomes by steering the native soil microbial communities towards plant-growth promoting and (a)biotic stress alleviating functions. To achieve this goal, I propose an innovative and ambitious multi-disciplinary approach based on the hypothesis that we can stimulate and train functional and taxonomic shifts in microbiomes on demand to remodel and improve existing communities, rather than introducing new elements in a native ecosystem. Additionally, by monitoring the microbiome changes, using beyond the state of art (multi)omics technologies, I will be able to identify microbes and functions fundamental to desirable microbiome traits. This study will suppose the first proof of concept of this novel integrative approach, opening new avenues for microbiome applications in agricultural settings. The findings of this study will be beneficial for improving agriculture sustainability but also will raise societal climate change awareness on the local and global scale.

Keywords: plant microbe interaction,sustainable agriculture,microbiomes,multiomics
Exometeorology: Probing Extrasolar Atmospheres (Exo-PEA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Ireland
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499964.0
EU funding (EUR): 1499964.0
Participants: 1
Project status: SIGNED

The exploration of worlds beyond our solar system aims to answer one of the most fundamental questions: Are We Alone in the Universe? Studying a diverse range of exoplanets is critical for investigating Earth-like exoplanets in the long-term as we develop the tools, facilities and techniques necessary for understanding their atmospheres in detail. Advanced telescopes such as the James Webb Space Telescope (JWST) and 30-metre telescopes (e.g. the Extremely Large Telescope, ELT; first-light ~2028) will enable direct exoplanet studies, but interpretation of these results will hinge on a thorough understanding of their complex weather phenomena. Exo-PEA is a transformational program that will utilise a novel combination of observational and computational data-driven techniques to reveal the physics of three critical weather phenomena in giant extrasolar worlds: clouds, winds and aurorae. Objective 1: Spatially-Resolved Investigations of Clouds My team will perform the first spatially-resolved investigations of clouds in extrasolar worlds, revealing the longitudinal and latitudinal behaviour of clouds. This objective will make use of data from JWST Cycle 2 PI Programs #3548, #3496 and #3486 as well as Co-I Programs #2965, #3375 and #3181. Objective 2: Wind Speeds in Extrasolar Atmospheres My team will pioneer the study of winds in imaged extrasolar atmospheres by measuring vertically-resolved winds in an extrasolar world for the first time and significantly increasing the number of wind speed measurements that exist. This objective will make use of data from JWST Cycle 2 PI Programs #3548 and #3496. Objective 3: Atmospheric Signatures of Aurorae My team will characterise the effects of magnetically-driven aurorae on extrasolar atmospheres for the first time beyond the solar system. This objective will make use of data from JWST Cycle 2 PI Programs #3548 and #3496.
Supporting optimisation of photovoltaic resource efficiency and sustainability (SOLARIS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Coordination and support actions
Countries involved: Germany,Norway,Spain,France,Türkiye,Switzerland
Call: Resource Efficiency of PV in Production, Use and Disposal (HORIZON-CL5-2024-D3-02, 2024)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 2921520.67
EU funding (EUR): 2921520.67
Participants: 6
Project status: SIGNED

With photovoltaics being expected as the main pillar of the future global energy system by 2050, understanding the underlying technological developments, their supply chain material flows, resource requirements, environmental life cycle impact and circular economy potential becomes crucial for the European continent. In the transition to an increasing electrification of the energy system, Photovoltaics gives Europe the opportunity to become independent from importing fossil fuels. With a circular economy approach – as PV technology is to almost 100% recyclable – supported by and eco design strategies, Europe has the opportunity to become less energy dependent from outside and at the same time significantly reduce the environmental impacts in its energy sector. The SOLARIS project has the expertise and is designed to give guidance and support this goal with underlying data on future market and technology development, related resource use and supply chains, environmental impact and recommendations on policy measures to guide European decision makers along this path in the future. Despite clear goals on PV deployment, support for the development of a European industrial supply chain has been minimal. SOLARIS will combine projected technology and market development scenarios from material mining to End of Life including recycling strategies for a deeper understanding of the future required material resources and waste recycling strategies throughout the whole PV value chain and analyse related environmental and social impacts and highlight opportunities for reducing the industry’s environmental impact and reduce resource criticalities. SOLARIS will also develop a database that compiles variables that contribute to GHG/CO2 and EPBT savings, which can be combined to show strategies and best practice to considerably reduce GHG/CO2 emission and EPBT time at each value stage. The outputs of SOLARIS will enable the PV industry to benchmark cross-comparisons in processes and materials which can incentivise best practice to lower the environmental impacts and increase preparedness for an EU PV supply chain.

Keywords: lifecycle inventory,resource efficiency,scenarios,material flow analysis,production,usage,end of life