Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Textured Perovskite Tandem Solar Cells (TEXTA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

Halide perovskites exhibit many ideal properties for photovoltaics, as highlighted by the fact that lead halide solar cells (SCs) have now reached efficiencies >25%, a value close the theoretical limit of single-junction SCs. A strategy to overcome this limitation is to combine two SCs, e.g. two perovskites of different compositions, into a tandem device to reduce thermalization and incomplete absorption losses. To maximize power output, each sub-cell must generate a maximum photocurrent matching that of the other sub-cell. This can be achieved by a. careful optimization of the perovskites thicknesses, b. minimizing parasitic absorption in transport layers and electrodes, and c. depositing the SCs on textured substrates. Textures are employed by some SC technologies, e.g. silicon, to enhance absorption and reduce reflection losses. Still, the use of textures in perovskite-based devices has been extremely challenging. Record perovskite-based single-junction and tandem devices rely on solution-processing (spin-coating), complicating and often preventing the uniform coverage of textured surfaces, in addition to hindering their deployment on industry-relevant sizes. This proposal aims to tackle both challenges by producing 30% perovskite-perovskite tandems, where all the functional layers (incl. perovskites) are grown conformally on textured substrates with high uniformity. To track and improve the optoelectronic quality of the perovskites when developing new processing routes, a combination of three in-situ optical spectroscopies (Absorption, PL & Raman) will be implemented. The methods will offer direct insights into the (trans-)formation of perovskites and emergence of defects or unwanted phases. With the means to monitor the quality of the perovskites, the optoelectronic quality of narrow- and wide-bandgap perovskites will be improved through process and additive engineering to finally yield highly efficient textured perovskite-perovskite tandems.

Keywords: halide perovskite,tandem solar cells,high performance,conformal growth
Dissecting spinal cord ependymal cell heterogeneity by single-cell transcriptomics (ECtomics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Cells with stem cell potential, this is with the ability to self-renew and generate specialised progeny, exist in the adult mammalian spinal cord. Previous studies localised this potential within the ependymal cell (EC) population. However, ECs are rather heterogeneous based on their morphological features and the expression of a handful of neural stem cell markers. In this interdisciplinary research proposal, I aim to uncover the cellular and molecular heterogeneity of ECs at the level of individual cells. I propose to take advantage of cutting-edge single-cell RNA-sequencing technology to obtain the transcriptomes of individual ECs from the spinal cord of adult mice. Using advanced computational methods, I will establish EC types and states and use pseudotemporal ordering to elucidate potential lineage relationships among ECs. I will then validate these findings in the tissue context, using high-resolution confocal microscopy. This first comprehensive characterisation of spinal cord ECs will provide novel and fundamental insights into how ECs possess and maintain their unique self-renewing properties. In the future, this will facilitate realisation of the potential of spinal cord stem cells for therapeutic purposes.

Keywords: neural stem cells,spinal cord,single cell rna sequencing,quiescence
Ghosts from the past: Consequences of Adolescent Peer Experiences across social contexts and generations (CAPE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-07-31
Duration (months): 66.0
Total project cost (EUR): 1464846.25
EU funding (EUR): 1103295.0
Participants: 2
Project status: SIGNED

Positive peer experiences are crucial for young people’s health and wellbeing. Accordingly, multiple studies (including my own) have described long-term negative psychological and behavioral consequences when adolescents’ peer relationships are dysfunctional. Paradoxically, knowledge on adult social consequences of adolescent peer experiences –relationships with others a decade later - is much less extensive. Informed by social learning and attachment theory, I tackle this gap and investigate whether and how peer experiences are transmitted to other social contexts, and intergenerationally, i.e., passed on to the next generation. My aim is to shed light on how the “ghosts from peer past” affect young adults’ relationships and their children. To this end, I examine longitudinal links between adolescent peer and young adult close relationships and test whether parents’ peer experiences affect offspring’s peer experiences. Psychological functioning, parenting, temperament, genetic, and epigenetic transmission mechanisms are examined separately and in interplay, which 1) goes far beyond the current state-of-the-art in social development research, and 2) significantly broadens my biosocially oriented work on genetic effects in the peer context. My plans utilize data from the TRAILS (Tracking Adolescents’ Individual Lives’ Survey) cohort that has been followed from age 11 to 26. To study intergenerational transmission, the TRAILS NEXT sample of participants with children is substantially extended. This project uniquely studies adult social consequences of peer experiences and, at the same time, follows children’s first steps into the peer world. The intergenerational approach and provision for environmental, genetic, and epigenetic mediation put this project at the forefront of developmental research and equip it with the potential to generate the knowledge needed to chase away the ghosts from the peer past.

Keywords: peers,adolescence,intergenerational,developmental
A novel gene therapy for epilepsy (CG01)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-08-01
End date: 2021-07-31
Duration (months): 36.0
Total project cost (EUR): 4801925.0
EU funding (EUR): 3361347.5
Participants: 1
Project status: CLOSED

The aim of this project is to clinically validate CG01 as a novel gene therapy for the treatment of drug-resistant epilepsy patients. Epilepsy affects approximately 50 million people worldwide. 6 million Europeans are afflicted by the condition which annually costs around EUR 15 billion in France, Germany and the UK alone. Current standard of care entails anti-epileptic drug (AED) therapy. However, up to 30% of epileptics (20 million people worldwide) are unresponsive. Research to date has shown that adeno-associated virus (AAV) vector-mediated upregulation of the human neuropeptide Y (NPY) and its receptor Y2 inhibits epileptic seizures. This has inspired CG to develop CG01, a type of advanced therapy medicinal product based on the introduction of genes that encode human NPY and Y2 via the AAV vector into the brain cells of epileptic patients. AAV has already been shown as clinically safe and validated gene delivery system. The current project aims to translate promising findings in animal research into valid human data by bringing CG01 through a Phase I/II trial in drug resistant epilepsy patients. This will be the basis for further clinical development and commercialisation of the product. CombiGene’s strategic operations are currently aligned to establish CG01 as a novel epilepsy treatment. This innovation has the potential to revolutionize treatment for epileptics by delivering a treatment that may cure rather than just alleviate symptoms. Developing CG01 is integral to the company’s growth and this project is therefore essential in fulfilling the company’s long term vision.

Keywords: epilepsy,anti epileptic drug resistant
Mechanisms that maintain centromere DNA repeats stability in human cells. (Centromere Stability)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

Cell division relies on centromeres, which connect chromosomes to the spindle for separating sister chromatids in mitosis. Human centromeres are composed of large arrays of repetitive DNA, which are often sites of aberrant rearrangements in cancer. While centromere defects can cause chromosomal instability, the molecular mechanisms that maintain their repetitive DNA stable are poorly understood. During the fellowship, I aim to investigate how human centromere stability is maintained and the consequences of centromere dysfunction in driving cancer and aging. To circumvent impeding technical barriers due to incomplete centromere sequence annotation, I have ideated the use of Chromosome Orientation Fluorescence In Situ Hybridization at human centromeres (Cen-CO-FISH; Giunta, 2018). Using this innovative technique, I revealed that CENP-A and CCAN (constitutive centromere-associated network) proteins prevent centromere instability, and this functionality is compromised in cancer cell lines and in primary cells undergoing senescence (Giunta & Funabiki, 2017); my data show that CENP-A may play a new role during centromere replication, preventing DNA damage, repeats shortening, and subsequent aneuploidy. I will use the Auxin-Inducible Degron (AID) system and CRISPR-Cas genome editing with high-throughput imaging of Cen-CO-FISH to identify the human centromere maintenance network and investigate the mechanisms of repeats stability. I will also examine the consequences of centromeres dysfunction, including changes in the size of the array, cell ploidy and proliferation dynamics, using a variety of validated and novel methods, including Cen-qRT-PCR, qFISH and cytogenetic assays. Altogether, the proposed research will unveil a novel conceptual framework to explain the fragility of repetitive centromere DNA and its consequences on cell physiology and disease. This work will lay the foundation for my future independent research on centromere instability in age-associated cancers.

Keywords: centromere,repetitive dna,genome stability,recombination,sister chromatid exchange,chromosome orientation fluorescence in situ hybridization co fish,senescence,cancer,aging,aneuploidy
FEASIBILITY ANALYSIS OF INNOVATIVE PRACTICES IN VIRTUAL TESTING METHODS FOR AIRCRAFT CERTIFICATION (FAVIT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain
Call: Virtual Testing Based Certification (H2020-CS2-CFP09-2018-02, 2018)
Start date: 2019-10-01
End date: 2022-03-31
Duration (months): 30.0
Total project cost (EUR): 714250.0
EU funding (EUR): 499975.0
Participants: 1
Project status: CLOSED

FAVIT main objective is to deliver a set of knowledge-based proposals for the improvement of aerospace standards and guidelines for the system suppliers and aircraft manufacturers. FAVIT will analyse the current aerospace standards and guidelines to identify how the design and verification processes can be enhanced to accelerate the processes using the state-of-the-art technologies based in virtual testing. FAVIT Project aims to become the tool for Clean Sky 2 to obtain this complete and accurate feasibility analysis of innovative practices in virtual testing methods for aircraft certification contributing to an innovative future framework of the aerospace standards in Europe. The methodology for the development of this study will include interaction with main stakeholders from the industry and the relevant certification authorities, as well as dissemination events to promote projects results.

Keywords: certification,standardization,aircraft,virtual,testing,methods,v model,mbse,modelling,aerospace
Examination of the recent past and future Response of coastal Dunes to Extreme storms and Sea level rise (ERoDES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 277061.76
EU funding (EUR): 277061.76
Participants: 1
Project status: SIGNED

The ERoDES research project aims, for the first-time, to develop our ability to understand, anticipate, and make projections on how coastal dunes would respond to future extreme storms and sea level rise along the Atlantic coast of Europe. As climate change is expected to cause more intense extreme weather events and an increase in extreme sea levels along the coastline of Europe and other continents, it is crucial to understand coastal dunes behaviour, since they serve as the first line of protection against coastal erosion and flooding. Field observations, a process-based and a reduced-complexity model will be used to hindcast and forecast dune behaviour at highly diverse coastal environments under previous and future sea level rise and extreme storms scenarios. These results will provide useful information and tools for short-and long-term coastal management strategies along the Atlantic coast of Europe. The researcher has demonstrated over the last few years a strong knowledge and understanding of geomorphological and hydrodynamic processes along diverse coastal environments, and aims to develop his numerical modelling skills through this project, benefiting from the strong experience of the supervisor. Knowledge exchange between the researcher and the host will offer the opportunity to explore niche topic such as the use of Satellite data, and to analyse outstanding but yet unexploited LiDAR datasets. The various achievements of this multidisciplinary project will be disseminated to both academic and non-academic key actors of coastal science and coastal management, adding social and economic repercussions to the scientific impact of the ERoDES project. Communication activities such as a scientific field trip, a science festival, and the presentation of new technologies used in coastal science like drones, will also be organised with the wider public to illustrate how EU-funded research aims to contribute in reducing risk in coastal flooding and erosion.

Keywords: geomorphology,coastal erosion,coastal dunes
Advanced High Aspect Ratio and Multicomponent materials: towards comprehensive intelLigent tEsting and Safe by design Strategies (HARMLESS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Austria,Germany,Spain,Germany,Poland,Sweden,Sweden,Switzerland,Sweden,Bulgaria,Finland,France,Netherlands,Denmark,United Kingdom,Denmark
Call: Safe by design, from science to regulation: multi-component nanomaterials (RIA) (H2020-NMBP-TO-IND-2020-twostage, 2020)
Start date: 2021-01-01
End date: 2025-01-31
Duration (months): 49.0
Total project cost (EUR): 7999085.0
EU funding (EUR): 7999084.75
Participants: 21
Project status: SIGNED

Next generation nanomaterials are a challenge for the established risk assessment and management paradigm. The regulatory frameworks have just been modified to address risk assessment of primary nanomaterials with simple coatings and are currently in the first phase of implementing methods and tools adequate for simple nanomaterials. Next generation nanomaterials and products thereof, are multiconstuent materials which exhibit much more complex behaviour, potentially including mixture toxicology. The morphologies and stoichiometry of next generation advanced nanomaterials are not harmless, as designs including high aspect ratio shapes and heavy metal content are abundant. By elucidating the role of nanostructures, their transformation and initiation of adverse outcome pathways, HARMLESS will provide novel tools, guidance and decision support for balancing functionality versus risk to ensure that the next generation nanomaterials will be harmless.

Keywords: safe by design,iata,risk assessment,risk reduction
The Extracellular Matrix in Epileptogenesis (ECMED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Italy,Spain,Belgium,Finland,Poland,France,Netherlands,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3047025.6
EU funding (EUR): 3047025.6
Participants: 11
Project status: CLOSED

Over 50 million people worldwide have epilepsy and 30% are resistant to our present therapies. Epilepsy, therefore, comprises a major burden to society and so there is a pressing need for new approaches to treatment. The brain extracellular matrix (ECM) plays a critical role in governing brain excitability and function. Although research into the role of the ECM in neuronal signalling and network function has advanced considerably in recent years, its full translational potential has yet to be realised. There is growing evidence for a major role of the ECM in epilepsy including the association between ECM protein mutations and epilepsy, changes in the ECM and associated proteins during the development of epilepsy and the strong association between the ECM and brain diseases associated with epilepsy including stroke, traumatic brain injury, neurodegeneration and autism. This proposal brings together considerable expertise from academic and industry partners in the biology of the ECM with experts in epilepsy research. This, therefore, represents a truly collaborative effort to determine not only the role of the ECM in the development of epilepsy but also novel approaches to treat and to prevent epilepsy. The academic partners will focus on specific research questions, whilst the industrial members will provide diagnostic, treatment and advanced research tools. The project has a strong translational theme and the combination of basic and translational science will be of great benefit for the training of young researchers. Trainees will be exposed to courses, workshops, joint research meetings and inter-laboratory visits. The focus of the training programme is on expanding knowledge and the application of such knowledge to address pertinent question relevant to the diagnosis, prognosis and treatment of epilepsy, so providing an ideal insight into translational neuroscience.

Keywords: extracellular matrix ecm,epileptogenesis,neuronal circuits,therapeutics,anti epileptogenic
Mobilization of chromium by organic matter in reduced systems (CHROMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: SIGNED

Long-term pollution mitigation requires a better understanding of the biogeochemical processes that regulate the behavior and fate of trace metals, such as chromium (Cr), in subsurface environments. The emerging role of organic ligands, including siderophores and organic acids, in the speciation, bioavailability and mobility of trace metals is receiving increasing attention. However, the relative importance of the opposing Cr reduction and mobilization processes in sediments remain poorly constrained, and the Cr-ligand interaction has not been explicitly determined. Whilst stable isotope compositions of Cr are an effective tool for assessing biogeochemical cycling and redox processes, there have been few studies reporting the isotope effect of ligand-induced Cr mobilization. This project combines an interdisciplinary set of field sampling, controlled experiments, isotopic analysis alongside geochemical modelling, aiming to test the hypothesis that (1) solid Cr can be effectively remobilized by organic matter in reduced environment despite Cr reduction, and (2) aqueous Cr can be stabilized in the form of organic complexes with a distinct Cr isotope signature. The extent and mechanism of Cr mobilization by organic ligands under various environmental conditions will be quantified. Stable Cr isotopes in sediment pore water will be accurately determined and validated as a tracer for Cr-ligand complexation. The fate of Cr in relation to Fe and organic ligands in sediments will be predicted. This project will shed new light on the role of organic ligands in the Cr redox cycle, and will reveal the sensitivity of subsurface environments to anthropogenic activities. This project includes both the transfer of knowledge to the host institution and the training of the candidate in advanced techniques. Results from this project will be disseminated to the environmental science and geochemistry research community and to the wider public.

Keywords: chromium,organic ligands,redox cycling,stable isotopes,sediments