Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
At the roots of Spatial Numerical Association: from behavioural observation to Neural Basis (SNANeB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2021-12-23
Duration (months): 36.0
Total project cost (EUR): 244269.0
EU funding (EUR): 244269.0
Participants: 2
Project status: CLOSED

Humans represent numbers on a left to right oriented mental number line, with small numbers located on the left and large ones on the right space. It has been suggested that the left-to-right orientation of the mental number line emerges as a result of exposure to formal instruction. Recent evidence has shown that pre-verbal infants and non-human animals associate numbers with space; suggesting that the spatial numerical association (SNA) originates from pre-linguistic and biologically determined precursors. Numerical knowledge constitutes a domain-specific cognitive ability, with a dedicated neural substrate located in the parietal cortices. The challenge at present is to explain how this neural substrate can determine a left-to-right orientation of the SNA, which is the main aim of this project. Here I will study the neural correlates of SNA from a comparative perspective, using domestic chicks and rhesus monkeys as animal models. Both species master numerical skills and have been used to understand the neural basis of cognitive processes. I will use paradigms which allow to test the presence of any facilitation to respond to small numbers on the left space and to large numbers on the right space. The neural correlates of SNA will be studied in monkeys employing a repetitive transcranial magnetic stimulation (rTMS), to understand whether neural perturbation could affect SNA, and in chicks using non-invasive techniques -e.g. monocular occlusion- to disentangle the engagement of each hemisphere in SNA. Overall this project will help in determining the neural basis of SNA. A better understanding of neural representation of numbers will permit optimized designs of clinical applications to enhance numerical comprehension. This might provide a valuable intervention for infants with potential problems in mathematical comprehension, as occurs in Williams syndrome or dyscalculia.

Keywords: numerical cognition,mental number line,spatial numerical association,domestic chicks gallus gallus,rhesus monkeys macaca mulatta
Functional networks and cancer roles of the essential histone chaperone FACT (SilentFACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Our knowledge of the mechanisms underlying cancer rapidly evolves. Diagnosis and treatment are improving, but cancer remains an urgent health burden. Whole-genome sequencing of cancers by the International Cancer Genome Consortium reveals that a key driving force in the etiology of cancer is the abnormal expression of chromatin regulators. The SilentFACT project focuses on an essential regulator of chromatin structure, the histone chaperone FACT. Recently identified small molecules disrupt normal FACT functions, and cancer cells stop growing when FACT levels are reduced. This reveals FACT as an anti-cancer target. We will apply potent cutting-edge genomics, quantitative proteomics and biochemical approaches to systematically dissect and validate the functional networks, novel interactors and chromatin targeting mechanisms of FACT. We will then subject the identified major interactors to a small molecule screen targeting FACT in human cancer cells. This will occur during secondments to the chemical biology platform of the Curie Institute in Paris and at an industrial partner. The SilentFACT project supports a Polish chromatin researcher for two years research and training at Munich University. Our timely research, training and communication aims, as well as exchanges with the international research community, will markedly advance the chromatin field, determine how this essential protein complex is involved in cancer and advance the therapeutic potential of FACT- targeted small molecules. SilentFACT will establish a solid basis for drug development, and advance the researcher’s leadership, networking and employability, helping to establish an independent research program at this exciting interface between basic chromatin science and translational medicine.

Keywords: histone chaperone,centromere,heterochromatin,cancer,yeast
QuickTicket (QuickTicket)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-10-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Mobile app for sell tickets for live shows with discounts and buy in two taps. Quickticket is a smartphone app where you can buy last minute tickets with big discounts. The main target of Quickticket is to make a success of every live show by selling all their tickets. Concert and theatre halls do not sell all their tickets on a daily basis. The European crisis has made the situation worse, the bigger the venue bigger the amount of empty seats, around 40% is empty during week days. The market of unsold tickets in Spain alone is bigger than 170 M EUR. This outcome provokes many theatres and concert halls to close due to the lack of business. The solution that Quickticket is proposing is to solve this problem by providing event promoters a tool to upload their spare tickets to the platform when they realize they will not sell out. Our aim is to optimize the capacity of their event and revenues from one side and from the other we provide to our users the best offers on live events on the market. Advantages QuickTicket: * For venues - Do not sell all their tickets - Having fix costs - the market of unsold tickets is really big * Users - Looking for activities for today and tomorrow (80% of tickets sold the day of the show) - Looking for the best offer (cash sensitive) - Smaller prices incentivize trying new things * Quickticket - Allows venues to optimize their capacity - Fast user activation (via personalized push notifications) - Best prices in the market Quickticket intends to bring something new to Europe by developing an app will let its users to know what is happening in your city and also other European cities, since swapping between cities is very easy, and if you are travelling to another European city you will be able to buy tickets from the same app. Quickticket is changing the way of people make plans in Spain and its prepared to do it all around Europe and the world. The novelty of our innovation is that we can sell last minute tickets in a very short time, thanks to our push notifications in such a way that we can give out tickets that would not have been sold otherwise and making theatres and concert halls make some profit from spare tickets. We are giving the event promoters a tool to upload their spare tickets and give them a last chance to be sold. Mobile apps are used for last minute decisions such as “Where is the closest Starbucks ?” “ How do I get from here to the metro Station?” We are talking about a new generation of customers that make “last minute decisions”, where Quickticket fits perfectly since it answers the question “What do I do tonight?”

Keywords: mobile,mobile ticketing
The steel industry, circularity and the stock-flow-service nexus (CircNexSt)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-03
End date: 2023-05-02
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

Steel is the world’s most recycled metal, yet only 21% of the global demand is met through scrap, which highlights the gap between the present reality and the ideals embedded in the concept of the circular economy. The latter is designed to increase material recoverability and product optimisation throughout the entire life cycle, resulting in less carbon emissions, waste and resource dependency. Within the steel industry, leading companies and professional bodies have sought to promote and embody the circular economy to advance sector sustainability. This project will use the Stock-Flow-Service (SFS) Nexus to quantify the circularity of an international steel company’s products from extraction to service. The SFS nexus is a conceptual framework that explicitly highlights the interactions, including trade-offs, between energy and material flows (e.g. coal, iron ore), material stocks (e.g. buildings, vehicles) and service provision (e.g. shelter, mobility). By applying this nexus, one can assess the overall environmental performance of a light weighting strategy by juxtaposing reduced fuel consumption and carbon emissions with the increased incorporation of complex material composites. The latter make energy savings possible but are difficult to re-use and recycle, thus reducing the circularity of the process. The project will use Material Flow Analysis and Dynamic Stock Modelling to quantify resource consumption and accumulation linked to the service provided by steel. A set of resource efficiency and circularity indicators will be developed to evaluate the environmental performance of steel products (and prototypes) under various business strategies, including stock optimisation, green leasing, and product-service systems. The project’s results and recommendations will support the steel company in their corporate sustainability targets and facilitate the accurate prediction and tracking of steel’s residual value and resource efficiency across their product range.

Keywords: circular economy,corporate sustainability,resource efficiency,social ecology,sustainable resource use
Automatic Hitching for theTotal Safety of the Farmers when Coupling machinery (SIWI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-02-01
End date: 2021-07-31
Duration (months): 30.0
Total project cost (EUR): 2149713.75
EU funding (EUR): 1504799.63
Participants: 1
Project status: CLOSED

The penetration of automation in the agricultural industry is forging ahead. Yet, the process of changing and hitching trailed implements, a key operation that every farmer performs many times per day, remains manually operated, as it was 50 years ago. Due to this, 40% of farmers deaths in farms are the result of being crushed by machinery such as tractors or implements, with fatal farms accidents costing to the EU society €923 million/year. The need for an automated, strong and reliable hitch system has never been greater. Listening intently to the needs of our customers, we invested 3 years of R&D to develop industry’s first fully automated hitch system. Our game-changing technology is 10x times better than closest substitutes and allows farmers to hitch their heaviest implements from tractor’s cabin, in less than 30sec. This redefines farm operations, enabling farmers to use only 1 tractor instead of 4 which is the current way of working, and brings huge cost savings enabling farmers to recoup their investment in our product in less than 258 working hours. Currently, our patent protected technology is at TRL6, with the system being optimised in our Danish facilities. With a feasibility plan developed under a Ph1 grant, we now seek a Ph2 grant to fine-tune our industrial-grade high pressure connection system and optimise our Machine Module to certify it for transport on public roads as per TÜV. Also, we will patent our new Machine Module and fully certify our systems for strength, reliability and safety. To speed-up market launch, we will showcase our products to key customers who have already expressed their interest. This will allow us to launch our products in Europe, Japan, Australia, Canada and the US, growing our business by €24 million in cumulative net profits by 2025. This cash-flow is vital to build our new facilities to meet market demand and continue improving our products, ultimately generating 18 new jobs in SIWI production and sales activities

Keywords: hiching system,farming machinery
European Virus Archive GLOBAL (EVA-GLOBAL)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Germany,Germany,Italy,Italy,Italy,Australia,South Africa,Switzerland,Slovenia,Belgium,Greece,Hungary,Slovakia,Sweden,China,Russian Federation,France,France,France,France,Netherlands,United States,Netherlands,United Kingdom,United Kingdom,United Kingdom,Senegal
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2019-1, 2019)
Start date: 2020-01-01
End date: 2024-09-30
Duration (months): 57.0
Total project cost (EUR): 13902748.75
EU funding (EUR): 13902748.75
Participants: 37
Project status: SIGNED

EVA-GLOBAL gathers 38 academic institutions at the forefront of human, animal and plant research in Virology, associated with key Non-Governmental Organisations including the World Health Organisation, OIE, FAO and related international organizations such as the CGIAR. This new project is built on the strong foundations constituted two previous EVA (2009-2014), FP7 and EVAg (2014-2019), H2020 projects. It includes high calibre institutes with the appropriate expertise to collect, characterise, standardise, authenticate and distribute human, animal and plant viruses. EVA-GLOBAL is conceived to be an open access entity aiming at developing synergies and complementary capabilities in such a way to offer an improved access to the researchers. A single-entry point, the web-based catalogue, gives a facilitate access to the end-user, to the collections including viruses, derived materials and engineered cells. This project will integrate 13 facilities dedicated to the high-risk pathogens manipulations (BSL4), which constitutes the largest BSL4 network worldwide. EVA-GLOBAL will also link up with other network-based virus associated programmes that exist globally. This unique advanced community aims at becoming the most responsive network to improve the control of emerging or re-emerging virus outbreaks at the global level. During the past EVAg project, this infrastructure has already been able to play a key role for the control of emerging virus diseases by the supply of unique reagents for the detection of viruses under the WHO umbrella. Through this new ambitious four-year project and the new institutes joining the consortium, EVA-GLOBAL will become the largest virtual virus collection for human, animal and plant viruses will move beyond the current state-of-the-art to provide an increasingly valuable resource and service to the scientific community, including government health departments, higher education institutes, industry and to the general public as well.

Keywords: virus collection,derived products,support to response,gold standard products
Investigating the Design and Use of Diagnostic Devices in Global Health (DiaDev)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: India,Sierra Leone,United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-05-01
End date: 2024-01-31
Duration (months): 81.0
Total project cost (EUR): 1479558.0
EU funding (EUR): 1306313.59
Participants: 5
Project status: SIGNED

Many people living in resource-poor settings have never had access to the laboratory facilities or technical expertise that are needed to diagnose diseases. With the development and deployment of a new generation of affordable, easy-to-use, and portable diagnostic devices that are designed for places with no laboratory infrastructure, the global landscape of diagnosis is dramatically changing. Can portable diagnostic devices strengthen health systems in resource-poor settings? DiaDev is the first study to comprehensively address this question through comparison across multiple devices, sites of production, and contexts of use. Diagnostic technologies are often championed as universal solutions to health equity and access. This ethnographic study investigates the extent to which how diagnostic devices work and what they can achieve depends on the locally specific relationships through which they are designed and used. Five ethnographic case studies from the USA, India and Sierra Leone examine the partnerships between donors, governments, humanitarian organisations and users that characterise current models of technological innovation and implementation in global health, the processes by which diagnostic devices are integrated with health infrastructures in target settings, and the practices of knowledge production and use they entail. The ultimate aim is to generate new insight into (i) changing relationships of power between governments, donors, and business in global health, and (ii) the ways in which diagnostic devices are transforming health systems in resource-poor settings. It will produce a new context-specific and comparative framework for exploring the opportunities and challenges involved in the design and use of diagnostic devices. Through innovative collaborative methods it will also develop a set of ‘health system strengthening tools’ that will enable stakeholders to improve the design and use of these devices in dialogue with the project findings.

Keywords: global health,institutions,partnership,value,humanitarian enterprise
Unraveling the mechanobiology of tissue growth in native and tissue-engineered heart valves (G-Valve)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-05-01
End date: 2018-08-20
Duration (months): 24.0
Total project cost (EUR): 174864.6
EU funding (EUR): 174864.6
Participants: 2
Project status: CLOSED

The currently available heart valve prostheses do not consist of living tissue and, hence, they cannot grow, repair, and remodel in response to changing demands. This restricts the use of valve replacements in pediatric patients, since they need multiple reoperations to accommodate somatic growth. Tissue-engineered heart valves (TEHVs) may be able to overcome this limitation due to their growth and remodeling potential. However, the exact growth and remodeling processes remain poorly understood, which has become evident in many pre-clinical studies where TEHVs lost their functionality over time due to adverse tissue remodeling. The goal of this proposal is to unravel the mechanisms of tissue growth in native valves and TEHVs by integrating advanced continuum mechanics and cell biology, in order to develop predictive models of valve growth that can guide and optimize tissue engineering of heart valves. To achieve this goal, I will first be trained in developing continuum models of valve growth in the lab of Dr. Kuhl at Stanford University, who is a leading expert in modeling soft tissue growth. Furthermore, I will be trained in cell biology and mechanobiology which will enable me to develop agent-based mechanobiological models as a driving mechanism for valve growth in the continuum models. I will use the obtained knowledge to analyze and predict growth of TEHVs in Europe. At this moment, mechanistic models of valve growth are not available. The models that I will develop during and after my training will provide crucial information for designing TEHVs with long-term functionality and growth potential, and will boost European excellence and competitiveness in the fields of biomechanics and tissue engineering. Moreover, the training that I will receive will significantly extend my scientific profile, and it will provide me the valuable international training at a prestigious academic institute that is required for pursuing an academic career in Europe.
Writing on the Margins: Graffiti in Italy (7th–16th centuries) (Graff-IT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Italy,Italy,Italy
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2499731.0
EU funding (EUR): 2232213.82
Participants: 3
Project status: SIGNED

In all modern languages, the word ‘graffiti’ is associated with social criticism, protest movements and vandalism. On the contrary, what historians call graffiti is unrelated to transgression. Nonetheless, contemporary and ancient graffiti share one important aspect: both are public writings, produced spontaneously and beyond any control from authorities. Graffiti give us access to the worldview of individuals in the past: this is why they are an important historical source, worthy of being considered, alongside the conventional sources. The Graff-IT project aims to develop a new interdisciplinary approach to the study of medieval and Renaissance graffiti (7th-16th c.) as a historical source, in order to allow a correct contextualization of graffiti within their space-time and social production frame. The project will focus on the following objectives: 1) Giving graffiti full dignity as a written source and asserting the study of graffiti as intrinsic to palaeography; 2) Overcoming the atomistic approach to graffiti, in order to identify new textualities and new languages; 3) Reading graffiti as a source for the history of devotional practices; 4) Interpreting graffiti as signs of the socio-cultural identity of people and places; 5) Exploring graffiti to change our perception of historical artworks, shifting the focus from the creation stage to its social function and use over time. The project will have an innovative and groundbreaking effect on the established method of historical investigation: different perspectives will merge towards an integrated approach that takes the multifaceted complexity of graffiti (writing, image, language, and material aspects) into account. Innovative tools and methods will be used to build out the first national graffiti survey and the related digital Archive. Other outputs are expected: 5 workshops; 2 international conferences and proceedings; a monograph; at least 15 open access articles; a virtual exhibition and a documentary.

Keywords: graffiti,public lettering,literacy,historical method,palaeography