Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Microbiota-immune interaction in colorectal cancer (IMMUNO_CRC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

The human gastrointestinal tract harbours trillions of bacteria that have co-evolved to play important roles in health and disease, conferring immunological, metabolic and neurological benefits to the host. This assemblage is known as the Gut Microbiota and has been a focus of investigation over the last decade. Altered gut microbiota composition has been associated with colorectal cancer (CRC), and studies in germ-free mice established an important role for some gut microbiota members in oncogenesis outcome, tumour progression and response to therapy. Data from the host laboratory show that patients with CRC harbour specific gut microbiota sub-types, among which some are associated with distinct mucosal gene-expression profiles. Thus either directly or through their metabolites, these tumour-associated microbiota appear to differentially recruit and interact with host inflammatory cells, which we hypothesize may be involved in different outcomes of carcinogenesis. The presence of particular immune cells is known to be prognostic of clinical outcome, because it often creates a tumour-promoting environment. Therefore, strategies aimed at manipulating the tumour-associated microbiota in CRC represent a promising therapeutic approach for patients. IMMUNO-CRC’s goal is to elucidate the mechanisms by which certain bacterial sub-types associated with CRC may alter immune function and influence clinical outcome. Using multicolour flow cytometry, I will analyse infiltrating immune cells characteristic of different inflammatory responses and microbiota sub-types. Histo-immunophenotyping analysis on tumour biopsies will determine their inflammation and cancer phenotype. Metabolomics will identify specific microbial metabolites involved in the regulation and progression of inflammation. Ultimately, this unique and innovative combination of techniques will pave the way for novel therapeutics targeting the human microbiota for cancer treatment.

Keywords: microbiota,colorectal cancer,inflammation
Integrated Zero Defect Manufacturing Solution for High Value Adding Multi-stage Manufacturing systems (ForZDM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Innovation actions
Countries involved: Germany,Spain,Italy,Spain,Austria,Austria,Germany,Italy,Italy,Italy,Italy,Norway,Sweden
Call: Zero-defect strategies at system level for multi-stage manufacturing in production lines (H2020-FOF-2016, 2016)
Start date: 2016-10-01
End date: 2021-03-31
Duration (months): 54.0
Total project cost (EUR): 7566108.75
EU funding (EUR): 5896860.4
Participants: 16
Project status: CLOSED

Manufacturing companies are continuously facing the challenge of operating their manufacturing processes and systems in order to deliver the required production rates of high quality products of increasing complexity, with limited use and waste of resources. "Zero Defect Manufacturing" (ZDM) is a recent paradigm aiming at going beyond traditional six-sigma approaches in highly technology intensive and strategic European manufacturing sectors through new knowledge-based approaches. The ZDM paradigm is of key importance to manage production quality targets in advanced manufacturing industries. The implementation of this paradigm in industry requires innovative defect management and control methods, novel technologies for in-line inspection and integration of knowledge management and ICT tools for smart and sustainable decisions in complex industrial scenarios, which are not available in the market. The aim of the ForZDM project is to develop and demonstrate tools to support the rapid deployment of ZDM solutions in industry and design more competitive and robust multi-stage manufacturing systems. The proposed ZDM approach is based on the combined adoption of new knowledge-based data-gathering and root-cause analysis solutions to reduce the generation of defects as well as new on-line defect management and improved production traceability solutions to mitigate the propagation of defects along the production line stages. This will be achieved through the proper integration of innovative enabling technologies, such as cyber-physical systems, selective inspection, advanced analytics and integrated process and part-flow control solutions.

Keywords: zero defect manufacturing,monitoring,distributed control,interoperability
Cancer: Activating Technology for Connected Health (CATCH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland,Spain,Spain,Ireland,Spain,Belgium,France,Netherlands,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2016-09-01
End date: 2020-08-31
Duration (months): 48.0
Total project cost (EUR): 2120806.44
EU funding (EUR): 2120806.44
Participants: 11
Project status: CLOSED

Advances in cancer diagnosis and treatment have been groundbreaking, and we are now considering some cancers as chronic disease rather than fatal illness. This moves the point of focus in the fight against cancer from sustaining life towards maximizing functional capacity and quality of life (QOL). A critical element in this shift has been the rise of active rehabilitation in the management of cancer. In the past 10-15 years we have seen the emergence of significant evidence for the clinical effectiveness of active rehabilitation in cancer care, both in maximizing functional capacity and QOL, and preventing secondary recurrence. However, many barriers to implementation of active rehabilitation in cancer care exist due to its profound physical and psychological implications. Technology advances such as gamification based on biofeedback, and neuromuscular electrical stimulation, can help address some of these barriers but much must be done before we can effectively marry the technological capability to the unmet clinical need. In particular we need to understand specific challenges and patient journeys associated with cancer care and how we can help patients to leverage psychological tools to better engage in their own care. We then need to optimize technological tools to meet patients’ rehabilitation needs, and finally, to understand how to bring resultant solutions to market where they can have maximal impact on quality of care. This can only be done by a multidisciplinary programme of research involving close collaboration between researchers in academic, clinical and industry settings. CATCH is a deep collaboration across academic, business and clinical sectors. Students will benefit from intersectoral secondments, interdisciplinary communication skills, public engagement and outreach while working on a programme of interrelated core research projects addressing gaps in the knowledge and evidence base for technology enabled cancer rehabilitation mentioned above.

Keywords: health care,data,change management,business models,connected health,e health,health,technology,health systems,health promotion
Energy efficient, primary production of manganese ferroalloys through the application of novel energy systems in the drying and pre-heating of furnace feed materials. (PreMa)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: South Africa,Germany,Germany,Germany,Norway,Norway,Norway,Finland,Slovakia,Poland,France
Call: Energy and resource flexibility in highly energy intensive industries (IA 50%) (H2020-NMBP-SPIRE-2018, 2018)
Start date: 2018-10-01
End date: 2023-03-31
Duration (months): 54.0
Total project cost (EUR): 11826828.75
EU funding (EUR): 10073272.5
Participants: 16
Project status: SIGNED

Global Manganese-alloys (Mn) are highly linked to the steel sector for key engineering applications in Europe. In 2017, Mn-alloy production was approx. 4 Mio tons, required 12,200 GWh electrical energy and emitted around 14.2 Mio tons of CO2. Therefore, an energy intensive and inherent cross-sectorial value chain that is, nowadays, led by the Asian market demand. PREMA is an ambitious initiative that aims at demonstrating an innovative suite of technologies (involving heat recovery and solar technologic approaches) that allow to pre-treat Mn ores, utilising more efficiently energy and material streams and decreasing direct and indirect CO2 emissions (along with SO2 and NOx). LCA and LCCA methodologies will be implemented from early stages to ensure the technical, economic and environmental viability of the solution across the whole Mn-alloys’ value chain. The vision of PREMA is thus to make the Mn-alloys sector in Europe more flexible, sustainable and attractive. In order to cover the whole value chain, there is a strong presence of South African (SA) partners in the consortium, SA being the top 1 in high quality Mn ores’ extraction and exports worldwide. A win-win situation in order to strengthen the Mn-alloys and steel value chains in Europe. PREMA consortium puts together a total of 11 production facilities spread over Europe and SA among 4 Mn producers, representing an aggregated process capacity of 380 MW (Transalloys in SA, Eramet in France and Norway, Ferroglobe in Norway and Spain and OFZ in Slovakia). The innovative character of the project is brought by major players in R&D across Europe and SA, with the Norwegian organisation SINTEF as coordinator. Last but not least, clustering with other EU initiatives, including other SPIRE projects, will be paid special attention in order to create awareness of the project developments from early stages of the demonstration.

Keywords: manganese alloys,energy efficiency,renewable energies applied to the industry,solar energy innovative technologies,sustainable process industries,circular economy
POWER BOX - HYBRID ENERGY STORAGE FOR ANY ENERGY SOURCE (POWER BOX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The construction sector is responsible for 50% of global GHG emissions. In fact, diesel generators supply 98% of the electrical power required in construction sites. These generators are usually over-sized in order to cover all power peaks while working at low loads most of the time (<50% of their capacity). Unfortunately, diesel generators have a very poor efficiency at low load levels which causes a waste of tremendous amounts of fuel along with increased emissions. Working at low levels also reduces the service life of the generator and entails high engine-servicing costs. xelectrix Power GmbH is an Austrian company specialized in construction equipment with energy-efficient drive technology. Strove by the need for a solution that would combine electric energy storage and grid stabilization and could work in parallel with any kind of energy source (renewable or not), we have developed Power Box: a “plug & play” energy storage system (battery pack and hybrid inverter – patent pending) that can work in parallel with any energy source (alternating AC or direct current DC) including diesel generators, renewables and the grid suiting the needs of construction sites and bigger operations. With Power Box, diesel generators and the grid always operate at optimal efficiency. During peak energy requirements, Power Box and the generator combine to meet these requirements while during periods of low loads, the power is taken directly from Power Box’s battery storage. Through this project, we aim to set the technical and commercial bases of Power Box optimization to then by mid-2021 commercialize it among construction companies who already own diesel generators and energy who need energy storage and stabilization solutions. By the lack of adequate competing solutions on the market along with the growing demand of power supply, we expect to sell at least 3,900 Power Box units in 5 years to generate €119M revenues (ROI 7.86).

Keywords: diesel generators,energy storage,power peaks,hybrid power systems,energy efficiency,inverter
Modelling of Twin Screw Granulation on Micro-Macro Scales (MODSIM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 184590.72
EU funding (EUR): 184590.72
Participants: 1
Project status: CLOSED

Pharmaceutical manufacturing companies use various powders to prepare granules/tablets with stable attributes. However, wastage costs in the manufacture of solid dose drugs are of the order $50 billion. Much of this is due to a lack of fundamental knowledge of the physical processes occurring inside the particulate processes. In this project, common manufacturing systems such as are twin screw granulator (TSG) to produce suitable granules/formulations will be studied. A fully mechanistic understanding of these processes will be undertaken with the objective of reducing the manufacturing wastage and handling cost of the TSG using the skills and knowledge of the experienced researcher (ER) and the host supervisor. Improving this efficiency will play a key role in ensuring a more sustainable production system through less wastage into the future, a societal challenge which will be met by the H2020 programme. MODSIM is a multidisciplinary project aimed at exploiting my background in mathematical modelling of particulate processes using population balances in an area of pharmaceutical solid drug manufacturing. Apart from its manufacturing potential, this research will broaden current understanding of micro scale processes inside the TSG using MC method. The project forms a collaboration between the world leading Bernal Institute for Process Engineering research laboratories and an SME and exploits the multidisciplinary nature of their studies. The resulting knowledge will help EU manufacturing enterprises, in particular SMEs, to adapt to global competitive pressures by improving the technological base of EU manufacturing from pharma and importantly potential translation into high-value bioprocessing and med-tech sectors. The proposed research will provide outstanding research-led training and falls within the H2020 excellence science remit.

Keywords: twin screw granulation,micro macro scales,monte carlo method,population balance modelling,model predictive control
CONcentrating EXcellence in UC3M - Postdoc Programme (CONEX-Plus)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2017, 2017)
Start date: 2019-03-01
End date: 2025-08-31
Duration (months): 78.0
Total project cost (EUR): 6372000.0
EU funding (EUR): 3186000.0
Participants: 1
Project status: SIGNED

CONEX-Plus is a training and mobility program that aims to accelerate the career development of a cohort of Experienced Researchers at UC3M in Spain. CONEX-Plus will offer 30 fellowships of 36 months each, for incoming mobility to UC3M. Building on the excellence of UC3M, the program will develop the next generation of research leaders in the strategic research areas that are identified in the Research and Innovation Strategy for Smart Specialisation (RIS3) strategy of the Madrid Autonomous Region, underpinned by Social Sciences and Humanities. The principles of the Charter and Code are applied throughout the program. Applicants will submit proposals on research topics freely chosen by them. There will be two calls where fellows will be selected following an open, transparent, merit-based, impartial and equitable selection procedure, based on international peer review and interviews. Training is received through the implementation of an individual interdisciplinary research project under guidance of a supervisor. Secondments are compulsory and will be supported by 12 non-academic and 2 academic entities. All fellows will participate in the CONEX-Plus training program, with dedicated modules on relevant transferable skills and Industry Training Blocks. The career development of all fellows will be supported by the use of a Career Development Plan and through regular supervision meetings. The interdisciplinary research program will provide fellows with excellent scientific and relevant transferable skills to communicate across and between research disciplines. Fellows will also learn how to work in and between different sectors. Both are requisites for achieving most future relevant scientific and industrial results. CONEX-Plus equips researchers with skills and expertise in research areas that are of strategic importance to UC3M, the Madrid region and Europe who will contribute to address future challenges for the benefit of European citizens and society.

Keywords: experienced researcher,training,career development,scientific excellence
STORAGE OF HYDROGEN: ALTERNATIVE PRESSURE ENCLOSURE DEVELOPMENT (SH2APED)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Italy,Belgium,Belgium,United Kingdom
Call: Development of hydrogen tanks for electric vehicle architectures (H2020-JTI-FCH-2020-1, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 1993550.0
EU funding (EUR): 1993550.0
Participants: 6
Project status: SIGNED

The goal of the SH2APED project is to develop and test at TRL4 a conformable and cost-effective hydrogen 70 MPa storage system with increased efficiency and unprecedented safety performance. The innovative storage system is composed of the assembly of 9 tubular vessels fitting into a design space of 1800x1300x140 mm used for the battery pack. Fire resistance and mechanical robustness are drastically improved while the cost is decreased by 20% compared to the state-of-the-art Type IV tanks. This architecture allows a modular system configuration fitting into the flat space of light-duty car underbodies. All the vessel and the system elements are being manufactured using know-hows and high-throughput processes. Performance parameters and KPIs are monitoring in compliance with the current regulations, codes and standards (RCS) aiming the update of RCS by new knowledge and technological breakthroughs and simplification of certification. Economic assessment for industrial mass manufacturing is in line with the expectations of the automotive industry. The SH2APED consortium is a strong partnership of two industrials, one federal institute and one university. Optimum CPV - Plastic Omnium is the leader in hydrogen vessels fabrication for the automotive industry. Misal Srl is the highly skilled on mechanical components machining. BAM is the expert on safety and reliability of high-pressure composite cylinders. Ulster University is one of key providers of hydrogen safety research globally. In addition, a vital contribution to the project is expected from the Advisory Board comprising vehicle manufacturers including Daimler, Toyota, Audi, Geely, FIA, GreenGT. They will advise the project on the SH2APED system integration in light-duty fuel cell vehicles and validate the project results. The project testing capabilities are reinforced by the unique facilities and experts in performance evaluation of hydrogen tanks from the Joint Research Centre of the European Commission.

Keywords: hydrogen storage,hydrogen vessel,70 mpa storage system,mechanical robustness,hydrogen safety,hydrogen system efficiency,fire resistance,optical fibres,hydrogen regulations,fuel cell vehicle
Investigations Supporting MOX Fuel Licensing in ESNII Prototype Reactors (INSPYRE)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Nuclear safety
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Finland,Sweden,Switzerland,Belgium,France,Netherlands,Netherlands,United Kingdom
Call: Materials research for Generation-IV reactors (NFRP-2016-2017-1, 2016)
Start date: 2017-09-01
End date: 2022-02-28
Duration (months): 54.0
Total project cost (EUR): 8500739.7
EU funding (EUR): 3998478.8
Participants: 15
Project status: SIGNED

INSPYRE, a proposal fully supported and endorsed by the Steering Committee of the EERA Joint Programme on Nuclear Materials, focusses on the investigation of fast reactor MOX fuel to support the licensing of the start-up cores of the ESNII reactor prototypes. It will: • Use carefully designed separate effect (modelling and experimental) investigations to accurately describe basic phenomena occurring in the fuel with sound physical models, expanding empirical fuel behaviour knowledge gained in the past in irradiation tests and post-irradiation examinations, • Characterize selected key irradiated fuel samples to fill clearly identified knowledge gaps, • Combine and leverage basic and technological research to enhance and extend the reliability range of traditionally deduced empirical laws governing performance of nuclear fuels under irradiation, • Implement the new models and data obtained in the fuel performance codes used for the design of ESNII systems and apply the improved codes to ESNII relevant conditions. The impacts of the INSPYRE project will be many. Fuel is at the heart of nuclear reactor systems, but its qualification and licensing is challenging due to the complex coupled phenomena (physical, chemical, radiation, thermal and mechanical) induced by fission. INSPYRE represents a paradigm shift. It will enable a timely, facilitated and cost effective licensing of fast reactor fuels, only achievable by generating validated simulation tools capable of limiting qualification to punctual dedicated irradiation experiments. Of foremost importance is the relevant and efficient leveraging of past knowledge, technological and basic science approaches to extend the applicability of codes. INSPYRE’s goals will be achieved by a well-balanced consortium from universities, research and industrial organisations already collaborating in the EERA JPNM, further augmented by a dedicated user group stemming from ESNII representatives, fuel vendors, utilities and TSOs.

Keywords: nuclear fuels,esnii systems,fuel performance codes,behaviour under irradiation,physics based models,modelling oriented experiments,model validation