Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Feminist Institutionalist Approach to Gender Equality in STEMM (FIAGES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-03
End date: 2020-09-02
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

“Feminist Institutionalist Approach to Gender Equality in STEMM” (FIAGES) addresses the research question: “is narrative congruence essential for progressing Gender Equality (GE)?” using the qualitative hypothesis that progress in GE is dependent on strong congruent narratives supporting of GE in academic and workplace organisations, in particular STEMM disciplines and high tech companies. Studying and working in organisations having a satisfactory level of gender equality can foster gender-sensitive innovation in STEMM fields in academia and in high tech companies, creating a virtuous circle that reinforces a culture of GE. It is hypothesised that when narratives are a) non-congruent; b) non-supportive; or c) congruent and non supportive, GE does not progress, while d) congruent and supportive narratives will favour progress in GE. Trinity College Dublin is well placed to support the planned research since it promotes an integrated approach to equality, mainstreams all gender-related policies and activities across the University; deepens partnerships to promote GE with key professional, service and business organisations in the wider community. The ER, with a strong competence in non-academic sectors, wishes to apply for tenured academic position in Gender Studies: the Trinity Centre for Gender Leadership, the Centre hosting the ER, provides excellent training opportunities and specific skills needed in gender studies, and the supervisor has an established international research profile strongly aligned to this application. Research outputs include two journal articles, a book, presenting the research at international conferences, and international seminars and webinars. A bilingual dissemination and communication plan will increase awareness of the research aims and results. Numerous outreach activities, including the use of social media, will allow the transfer of knowledge in academy and companies, and also to the general public.
FOOD IQ. Eat out knowledge on European Researchers? Night 2021 (FOOD IQ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Netherlands
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020bis, 2020)
Start date: 2021-05-01
End date: 2022-02-28
Duration (months): 10.0
Total project cost (EUR): 161036.25
EU funding (EUR): 161036.0
Participants: 1
Project status: CLOSED

Food for Thought is a project that promotes science and scientists around the topic of healthy food in an interactive, accessible and innovative way. Our main goal is to teach residents of the Northern Netherlands, of all ages, more about healthy food, the impact of science on public health and about researchers and their profession. The project exists of three parts: Main event: Aletta’s Kitchen Aletta’s Kitchen is an entertaining and educational show designed to involve researchers and the audience to build a bridge between these two worlds. Named after a renowned Dutch persona of the medical field, Aletta Jacobs, the show invites multidisciplinary researchers to share their research findings connected to the topic of Food for Thought. Two different shows will be created; one as part of the education programme and one for adult residents of the region. Pre-event: Education program Our education program will teach children not only about food but also about the science of it. It is important that children know that food takes time to grow, that milk comes from a cow and a tomato grows on a plant. But also what their own food environment looks like and what food does in the body. As part of the program researchers will visit the schools to talk about their knowledge and research regarding the topic. By bringing researchers closer to the children we increase their awareness of research, creating an understanding of the impact of researchers’ work on their daily life and to encourage the pupils to embark on research careers. Installation An interactive installation facilitates accessible encounters between public health researchers and other residents of the Northern Netherlands. The visitor will gain insight into the process of knowledge development and the role of science in everyday life. Moreover, the visitor experiences how he/she can - directly or indirectly - take more control of her own health and the people around her.

Keywords: interdisciplinarity,food science,children,impact,health,public engagement,interactive exhibit,schools,show
ATRIAL FIBRILLATION INTEGRATED APPROACH IN FRAIL, MULTIMORBID, AND POLYMEDICATED OLDER PEOPLE (AFFIRMO)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Italy,Italy,Italy,Italy,Belgium,Serbia,Belgium,Bulgaria,Romania,Sweden,Belgium,United Kingdom,United Kingdom,United Kingdom,Denmark
Call: Healthcare interventions for the management of the elderly multimorbid patient (H2020-SC1-2020-Two-Stage-RTD, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 5998753.25
EU funding (EUR): 5998753.25
Participants: 20
Project status: SIGNED

Multimorbidity is a common condition in older age, and can substantially influence individuals’ health and quality of life, making management more difficult. A single-disease approach with fragmented care is still prevalent in current healthcare systems despite multimorbidity representing a heterogeneous spectrum of disease combination(s). On this background, the novel approach underpinning the AFFIRMO project is to focus on clusters of multimorbidity where atrial fibrillation(AF) represents one of the chronic conditions. Improving the management of AF in the context of multimorbidity may benefit individuals on a larger scale, with a holistic approach to optimize clinical management of older AF patients taking into account the multifaceted aspects of individuals’ health, including multimorbidity, polypharmacy, personal preferences, and social context. First, the project aims to identify different clusters of multimorbidity in older patients with AF. Second, AFFIRMO aims to assess the needs of patients, caregivers, and health professionals for the comprehensive management of multimorbidity including AF, and to examine ways of optimizing care and self-management. Third, AFFIRMO will develop, implement and test the effectiveness of a patient-centered approach on older multimorbid AF patients in the clinical practice. We aim to adapt, implement and promote a care pathway, in older patients with multimorbidity. A specific objective will be to develop an interoperable care framework that can facilitate the application of this personalized care pathway, that bridges the continuum between primary and secondary care, with the active involvement of patients with shared decision-making. A further aim will be to model the impact of multimorbidity including AF on healthcare costs and the health economic benefits by the proposed integrated care pathway. Finally, subgroup analyses would assess differences on outcomes of in relation to gender and social inequalities.

Keywords: atrial fibrillation,multimorbidity,polypharmacy,patient centred,integrated care
Digital twins for model-driven non-invasive electrical brain stimulation (Neurotwin)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Spain,Italy,Sweden,United States
Call: FET Proactive: emerging paradigms and communities (H2020-FETPROACT-2020-2, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 4485736.25
EU funding (EUR): 4485735.0
Participants: 8
Project status: SIGNED

Neuropsychiatric disorders are a leading cause of global disability-adjusted life years, and solutions are lacking. Can digital twins be useful? At least in some cases, we hold they will be central to progress. Recent findings suggest that non-invasive brain stimulation may be a valuable option in conditions such as epilepsy or Alzheimer's (AD). Still, a better understanding of mechanisms and patient-specific factors is needed. Personalized hybrid brain models uniting the physics of electromagnetism with physiology – neurotwins or NeTs – are poised to play a fundamental role in understanding and optimizing the effects of stimulation at the individual level. We ambition to deliver disruptive solutions through model-driven, individualized therapy. We will build a computational framework – weaved and validated across scales and levels of detail– to represent the mechanisms of interaction of electric fields with brain networks and assimilate neuroimaging data. This will allow us to characterize the dynamical landscape of the individual brain and define strategies to restore healthy dynamics. Benefitting from existing databases of healthy and AD individuals, we will deliver the first human and rodent NeTs predicting the effects of stimulation on dynamics. We will then collect detailed multimodal measurements in mice and humans to improve the predictive power of local and whole-brain models under the effects of electrical stimulation, and translate these findings into a technology pipeline for the design of new personalized neuromodulation protocols which we will test in a cohort of AD patients and healthy controls in randomized double-blinded studies. With research at the intersecting frontier of nonlinear dynamics, network theory, biophysics, engineering, neuroscience, clinical research, and ethics, Neurotwin will deliver model-driven breakthroughs in basic and clinical neuroscience, with patients ultimately benefiting from safe, individualized therapy solutions.

Keywords: non invasive brain stimulation,hybrid brain models,alzheimer s disease
Advanced Materials Research Postdoctoral Fellowship Programme (ADMIRE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Ireland
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2019, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1765440.0
EU funding (EUR): 882720.0
Participants: 1
Project status: SIGNED

Advanced materials science is one of the key enabling technologies identified by the European Commission as boosting European competitiveness, creating jobs, and supporting growth. ADMIRE is an innovative postdoctoral fellowship programme providing interdisciplinary and intersectoral training in strategic priority areas of advanced materials research, aligned with the strengths of AMBER: SFI Research Centre for Advanced Materials and BioEngineering Research. The aim of ADMIRE is train the next generation of research leaders in Europe in advanced materials science. A rigorous training programme will equip the fellows with the skills and flexibility to develop independent careers in their field of research in academia or industry. The ADMIRE programme will fund 12 two-year incoming fellowships in Ireland in the area of advanced materials, with fellows being recruited through 2 calls for proposals over the 60 month duration of the project. AMBER/TCD will contribute €1.19M to support the implementation of the programme, and will ensure that a fair, transparent, open and merit based recruitment process is implemented in the 2 calls. ADMIRE fellows will be based in one of the 8 academic partners of AMBER, and they will have access to the full range of AMBER state of the art facilities and expertise at these locations. Principal investigators across the academic partners will supervise, host and train fellows. Industry partners will host fellows during secondment periods and will contribute to industry relevant training in the ADMIRE programme. Fellows will have complete freedom of choice in their supervisor, host institution and research topic, provided it aligns with the existing research priorities within AMBER. ADMIRE is an exciting new strategic endeavour which will contribute to AMBERs core mission of generating world-class materials innovations and translating these into impact communities nationally and internationally.

Keywords: advanced materials research,bioengineering,interdisciplinary training,postdoctoral,materials for health,2d materials,material synthesis and characterisation,biomaterials,intersectoral
Symbiont-mediated defense of amoebae against Legionella pneumophila - molecular mechanisms and pathogen ecology (SymPathInfect)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2018-09-24
Duration (months): 24.0
Total project cost (EUR): 178156.8
EU funding (EUR): 178156.8
Participants: 1
Project status: CLOSED

Legionellae are opportunistic human pathogens infecting thousands of people annually in Europe. These bacteria are ubiquitous in many natural and man-made water systems, where they survive as free-living organisms in biofilms or intracellularly within a variety of protozoa. Free-living amoebae are the main route for spread and replication of legionellae in the environment, and infection of humans generally occurs via amoebae as vectors. Amoebae are frequently associated with bacterial endosymbionts, and recent data suggests that these symbionts interfere with replication of legionellae in amoebae thereby protecting the amoeba host from legionellae-induced lysis. The aim of this proposal is to further investigate this phenomenon of symbiont-mediated defense in protozoa, and to assess its implications for the ecology and transmission of legionellae. To shed light on the molecular and physiological interactions during infection of symbiont-containing amoebae with Legionella pneumophila, co-infection experiments will be performed and analyzed by state-of-the-art molecular methods including transcriptomics, proteomics and metabolomics, isotope profiling and chemical imaging techniques. Infection experiments will first be performed under controlled laboratory conditions to understand the interaction between amoeba, their bacterial symbionts and L. pneumophila, to analyse the molecular cross-talk, and to determine the mechanism of competition between the bacterial partners in this association. Subsequently, mesocosm experiments simulating environmental conditions will help to understand the impact of bacterial symbionts of amoebae on L. pneumophila spread and replication in the environment. Taken together, the comprehensive analysis of symbiont-mediated defense in amoebae will provide a new perspective on the ecology of L. pneumophila and lead to a better understanding of the role of amoebae and other microbes in water-borne disease outbreaks.

Keywords: microbial ecology,environmental microbiology,free living amoeba
Pathoecology of Vibrio cholerae to better understand cholera index cases in endemic areas (CholeraIndex)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2018-02-01
End date: 2024-01-31
Duration (months): 72.0
Total project cost (EUR): 1999988.0
EU funding (EUR): 1999988.0
Participants: 1
Project status: SIGNED

Cholera is one of the oldest infectious diseases known and remains a major burden in many developing countries. The World Health Organization estimates that up to 4 million cases of cholera occur annually. The transmission of cholera by contaminated water, particularly under epidemic conditions, was first reported in the 19th century. However, early volunteer studies suggested that an incredibly high infectious dose (ID) is required to produce disease symptoms, in contrast to most other intestinal pathogens. Therefore, the mechanism of infection of index cases at the onset of an outbreak is unclear. This proposal aims to fill this knowledge gap by studying how the environmental lifestyle of the causative agent of the disease, the bacterium Vibrio cholerae, may prime the pathogen for intestinal colonization. We hypothesize that one of the natural niches of the bacterium (chitinous surfaces) fosters biofilm formation and provides a competitive advantage over co-colonizing bacteria. As an adaptive trait, passage of chitin-attached sessile V. cholerae through the acidic environment of the human stomach might be vastly facilitated compared to planktonic bacteria. Moreover, interbacterial warfare exerted by V. cholerae on these biotic surfaces may help the pathogen overcome the colonization barrier imposed by the human microbiota upon ingestion. The mechanism by which V. cholerae leaves the sessile lifestyle and the regulatory circuits involved in this process will also be investigated in this project. In summary, our goal is to elucidate the environmental community structures of V. cholerae that may enhance transmissibility from the ecosystem to humans in endemic areas resulting in the infection of index cases.

Keywords: vibrio cholerae,opportunistic pathogens,ecology,biofilm formation,regulatory networks,type vi secretion
Ultra-sensitive NMR in liquids (BetaDropNMR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-10-01
End date: 2022-03-31
Duration (months): 78.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

The nuclear magnetic resonance spectroscopy (NMR) is a versatile and powerful tool, especially in chemistry and in biology. However, its limited sensitivity and small amount of suitable probe nuclei pose severe constraints on the systems that may be explored. This project aims at overcoming the above limitations by giving NMR an ultra-high sensitivity and by enlarging the NMR "toolbox" to dozens of nuclei across the periodic table. This will be achieved by applying the β-NMR method to the soft matter samples. The method relies on anisotropic emission of β particles in the decay of highly spin-polarized nuclei. This feature results in 10 orders of magnitude more sensitivity compared to conventional NMR and makes it applicable to elements which are otherwise difficult to investigate spectroscopically. β-NMR has been successfully applied in nuclear physics and material science in solid samples and high-vacuum environments, but never before to liquid samples placed in atmospheric pressure. With this novel approach I want to create a new universal and extremely sensitive tool to study various problems in biochemistry. The first questions which I envisage addressing with this ground-breaking and versatile method concern the interaction of essential metal ions, which are spectroscopically silent in most techniques, Mg2+, Cu+, and Zn2+, with proteins and nucleic acids. The importance of these studies is well motivated by the fact that half of the proteins in our human body contain metal ions, but their interaction mechanism and factors influencing it are still not fully understood. In this respect NMR spectroscopy is of great help: it provides information on the structure, dynamics, and chemical properties of the metal complexes, by revealing the coordination number, oxidation state, bonding situation and electronic configuration of the interacting metal. My long-term aim is to establish a firm basis for β-NMR in soft matter studies in biology, chemistry and physics.

Keywords: laser spectroscopy,optical pumping,beta detected nmr,radioactive ion beams,bioinorganic chemistry,metal interactions with biomolecules,liquid nmr
Learning From Failing and Passing Executions At the Speed of Internet (Learn)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-10-01
End date: 2019-09-30
Duration (months): 48.0
Total project cost (EUR): 1141875.0
EU funding (EUR): 1141875.0
Participants: 1
Project status: CLOSED

Modern software systems must be extremely flexible and easily adaptable to different user needs and environments. However, this flexibility also introduces relevant quality issues. These problems are so common that is sufficient browsing the Web to find millions of reports about failures observed after updates and incompatibilities caused by the interaction of a newly installed component with the existing components. The impact of problems introduced by end-users can be dramatic because end-users can easily modify applications, like developers do, but end-users have neither the knowledge nor the skill of developers, and they cannot debug and fix the problems that they unintentionally introduce. It is thus necessary to timely develop novel solutions that can increase the reliability of the moderns systems, which can be extended and adapted by end-users, with the capability to automatically address problems that are unknown at development-time. The Learn project aims to produce innovative solutions for the development of systems that can work around the problems introduced by end-users when modifying their applications. The three key elements introduced by Learn to automatically produce a (temporary) fix for the software are: (1) the definition of the InternetLearn infrastructure, which is a network infrastructure that enables communication between every individual instance of a same program running at different end-users’ sites, thus augmenting each application with the capability to access a huge amount of information collected in-the-field from other sites; (2) the definition of analysis techniques that can learn the characteristics of successful and failed runs by monitoring executions in the field from a number of instances running at many end-user sites; and (3) the definition of techniques for the automatic generation and actuation of temporary fixes on an Internet (World) scale.

Keywords: automatic debugging,self repairing programs,anomaly detection