Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
From small-scale cooperative herding groups to nomadic empires – a cross-cultural approach (COMPLEXITY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Norway
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1998859.0
EU funding (EUR): 1998859.0
Participants: 1
Project status: SIGNED

The main question of this research project is: can political complexity evolve from small-scale cooperative groups? The predominant view of nomadic empires – that they are caused by contact with agricultural neighbours – cannot explain how pastoralists transitioned from small, kin-based cooperative herding groups to complex hierarchical groups with the power to conquer their sedentary neighbours. By perceiving cooperative herding groups as the building blocks of nomadic societies, this project aims to develop a theoretical explanation of pastoral political organisation ranging from acephalous societies in Africa to imperial confederations in Inner Asia. While cooperative herding has been documented, previous studies have been based on single case studies. Thus, a cross-cultural investigation of pastoral cooperation is lacking. There is also a view that livestock, as the primary source of wealth, limits the development of inequalities, making pastoralism unable to support complex or hierarchical organisations. However, evidence indicates that environmentally induced livestock losses exacerbate rather than limit the development of wealth inequalities. COMPLEXITY rectifies this situation through three steps. First, by combining a systematic literature review of the ethnographic material with information in the eHRAF World Cultures database, COMPLEXITY will cross-culturally document the prevalence of cooperative herding groups. Second, by using a pluralistic methodology, e.g., experimental economic games, observations and interviews, COMPLEXITY will comparatively investigate to what degree pastoral cooperation is structured by evolutionary factors – such as kinship, reciprocity, social network structure, and norms – and investigate how cooperation affect pastoral performance and inequality. Third, by combining empirical data with modelling techniques, COMPLEXITY investigates whether cooperative herding groups can be considered prototypes for more complex organisations.

Keywords: human behavioural ecology,evolutionary social science,cooperation,nomadic pastoralism
Spatial skills and mathematics, towards a causal understanding of mechanisms (SPATHS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,United Kingdom
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 2
Project status: SIGNED

Difficulties in learning maths usually begin at the start of education and are robust over time. The number of students not reaching basic levels of maths achievement remains a major societal challenge, at a time when societies are increasingly demanding maths skills due to scientific and industrial progress. Research examining the key cognitive foundations for successful maths learning has identified spatial skills as a promising potential contributor to maths development. Nevertheless, how and why SPatial skills contribute to mATHS learning remains elusive. SPATHS will therefore develop a new framework that aim to understand the causal mechanisms via which spatial skills impact maths learning. This will be done firstly by using graphical causal models, in particular Directed Acyclic Graphs (DAG), to draw causal inferences from observational data. This technique, originally developed for computer science and novel to cognitive and developmental psychology, is a way of visually representing and testing a priori causal assumptions. Various spatial skills and maths abilities will be tested and causal pathways between the different abilities will be estimated in a cross-cultural context, which varies in the extent to which children start formal school (start at 5 vs. start at 6 years) and allows us to generalise findings across different educational contexts. Second, to empirically validate the findings from the causal models, a training experiment will manipulate the learning of spatial skills in 5-and 6-year-olds. SPATHS will unravel long-awaited knowledge about the mechanism underlying the spatial-maths association. This is essential for future research into efficient interventions to improve maths and to make spatial training programs more effective. Moreover, by introducing DAGs to cognitive and developmental psychology, SPATHS will provide the possibility to test causality in natural environments (e.g., schools) in which experimental data are difficult to obtain.

Keywords: numerical cognition,spatial skills,mathematics
Endoscopic brush cytology and single cell clinal dynamics of early easophageal adenocarcinoma for detecting cost effective surveillance strategies and prediction of cancer recurrence (ENDEAVOR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Research and Innovation actions
Countries involved: Belgium,Germany,Italy,Ireland,Sweden,Spain,France,Netherlands,Denmark
Call: Pragmatic clinical trials on minimally invasive diagnostics (HORIZON-MISS-2023-CANCER-01, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 6726488.69
EU funding (EUR): 6726488.68
Participants: 13
Project status: SIGNED

In many European countries the recent rise in incidence of esophageal adenocarcinoma (EAC) is without precedent. EAC is notorious for its highly aggressive biological behavior leading to invasive disease and early metastases. The only way to reduce mortality is through treatment in early stage of the cancer. EAC has a well recognized premalignant precursor lesion identified as esophageal metaplasia, or Barrett’s Esophagus (BE), which offers important opportunities for treatment in early stages of cancer which may reach 5 years survival rates up to 80%. However, these patients need to be monitored constantly for timely intervention in case of disease recurrence or metastases. The problem is that after endoscopic treatment up to 30% of cases will develop recurring cancers or even present with metastases, which requires additional endoscopic treatments or surgery. Currently it is impossible to predict which of the treated BE patients with will have stable disease and which will recur or progress to invasive cancer. As a consequence all treated patients need to remain in frequent endoscopic surveillance. This leads to over-treatment of a large group of BE patients and under-treatment of those with more aggressive disease. There is a low cost effectiveness of endoscopic therapies, low quality of life of patients and poor satisfaction of care providers. An accurate risk stratification method for early AEC in BE patients is therefore an unmet clinical need. The ambition of the ENDEAVOR consortium is to implement an innovative risk stratification method, which encompasses minimally invasive cell collection supplemented by single cell genomic analysis to address this specific need. Taking into account patient characteristics, gender dimensions, an optimal model model will be tested in a randomized controlled prospective trial. Future implementation of this method will reduce health care costs, increase quality of life and satisfaction of health care providers. This action is part of the Cancer Mission cluster of projects on Diagnostics and Treatment (diagnostics).

Keywords: clinical trial personalised medicine quality of care
European Underground H2 STorAge Reference System (EUH2STARS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Austria,Netherlands,Spain,Poland,Hungary
Call: Large-scale demonstration of underground hydrogen storage (HORIZON-JTI-CLEANH2-2023-1, 2023)
Start date: 2024-01-01
End date: 2029-09-30
Duration (months): 69.0
Total project cost (EUR): 27228904.25
EU funding (EUR): 19655460.13
Participants: 12
Project status: SIGNED

The overall aim of the project is to demonstrate underground hydrogen storage in depleted porous natural gas reservoirs at TRL-8. RAG Austria AG is in the unique position to start with an already existing pilot facility, developed within the framework of the USS-2030 project (www.uss-2030.at) to TRL 6. EUH2STARS will bring the pilot to TRL8 using results of several relevant projects (HyUSPRe, HyStoRIEs, Underground Sun Storage, Underground Sun Conversion and others). To achieve the overall aim and maximize the exploitation of the project results for replication in other regions of Europe the following specific objectives and outcomes are planned: - Provide recommendations to best manage all environmental, legal and (future) regulatory, societal and market-related aspects to ensure a successful implementation of an underground hydrogen storage facility in Europe (WP 1) - Provide recommendations on the topic of Health, Safety, Environment and Quality (HSEQ) including a monitoring plan to ensure an ALARP (as low as reasonably practicable) risk level when operating the demonstration site and future commercial storage sites (WP 2) - Run 4 cycles of seasonal operation with different characteristics and usage profiles to demonstrate the ability to integrate with different energy infrastructure systems with highest purification levels of Hydrogen (WP 3) - Show transformation pathways to replicate demonstrator findings in full-scale commercial settings at existing underground gas storage facilities and new to be developed storage sites in depleted natural gas reservoirs in Europe located in Austria (RAG), The Netherlands (Shell), Hungary (HGS), and Spain (TES) (WP 4) - Show how to integrate hydrogen storage facilities into the local, national and European energy infrastructure and market by showcasing specific use cases in AT, HU, NL and ES and other use cases including the integration into the European Hydrogen Backbone (WP 5) - Establish a sound interactive stakeholder involvement process to maxim replication potential and exploitation of the demonstrator results (WP 6). Our EUH2STARS mission is: Best practice demonstrator for a competitive, complete and qualified large-scale hydrogen storage system using a porous subsurface reservoir to enable the integration of European renewable energy sources.

Keywords: hydrogen,porous reservoir,hydrogen production,hydrogen storage,hydrogen withdrawal,demonstration plant,upscaling,replication
Implementation of an upgraded strategy to reach zero HIV transmission by breastfeeding in rural and urban settings in Zambia – the PROMISE-ZERO study (PROMISE-ZERO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: France,Norway,Zambia,Uganda
Call: Promoting implementation of research results into policy and practice (HORIZON-JU-GH-EDCTP3-2022-01, 2022)
Start date: 2023-07-01
End date: 2027-06-30
Duration (months): 48.0
Total project cost (EUR): 3995300.0
EU funding (EUR): 3995300.0
Participants: 5
Project status: SIGNED

Most cases of paediatric HIV now occur during the breastfeeding period. Through an EDCTP-2 funded randomized controlled trial in Burkina Faso and Lusaka, we tested a postnatal prevention strategy relying on point of care (POC) early infant diagnosis (EID) and maternal VL tests for same-day infant lamivudine initiation when VL>1000 copies/mL until the end of breastfeeding, and maternal ART optimization. At the 2nd immunization visit (EPI-2), maternal HIV status was reassessed and infants from HIV-positive mothers were enrolled. Among the 754 children in each arm, the 12-month transmission rate was 1.16/100pers-yrs (CI:0.44-2.60) in the control arm vs. 0 (97.5%CI: 0.71) in the intervention arm. The period at risk for infant (i.e.HIV VL>1000c/mL and no prophylaxis) was 5.96/100pers-days (95%CI: 5.85-6.1) vs. 0.36 (95%CI: 0.34-0.36). The primary objective of the proposal is to assess the effectiveness of a similar intervention in 2 provinces of Zambia, to reach zero postnatal transmission. For this implementation research proposal, we will use the RE-AIM framework. We designed a cluster randomized controlled arm with 2000 HIV-exposed HIV-negative children (1000 per arm) recruited at EPI-2 visit, in 40 clusters (maternal & child health centres) matched for district and size. The primary trial outcome is postnatal HIV infection at 18 months. The EID and VL tests will be organised at the district level with a mobile team equipped with POC machines, and one referral MCH centre equipped with Xpert platform. Research capacity will be built through PhD fellowships. By demonstrating the (cost)-effectiveness of POC tests and infant lamivudine (health technologies) to prevent infant HIV infection, identifying and addressing barriers to uptake in RE-AIM, notably via end-users participation, and ensuring the translation of research findings into policy through the strong involvement of policy makers, this study addresses both objectives of EDCTP-3 and those of the present call.

Keywords: implementation research for the prevention of mother to child hiv postnatal transmission
Building Resilient Innovations in Democracy, Governance and Excellence (BRIDGE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Social Sciences and Humanities
Countries involved: Ukraine,Netherlands,Estonia,Germany
Call: Twinning Green Deal (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 1498575.32
EU funding (EUR): 1498575.32
Participants: 5
Project status: SIGNED

The BRIDGE project aims to boost the innovation capacity of the Kyiv School of Economics (KSE, Ukraine) with particular attention to research-to-policy transfer over a pressing policy problem: the role of decision support and deliberative formats for citizen participation (citizen assembly) in the reconstruction of housing and infrastructures, destroyed by the Russian war against Ukraine. The project fills broader gaps in public administration theories and practice on how to blend representative and participatory models of democracy during crisis situations to achieve efficient and legitimate policy outcomes in democracies. To achieve this goal, KSE has partnered with three excellent institutions - Erasmus University Rotterdam (EUR, the Netherlands), Berlin University of Technology (TU Berlin, Germany) and University of Tartu (UTARTU, Estonia). Partners bring complementary expertise in developing and studying digital democratic innovations, such as citizen assemblies, and using public governance approaches to research and improve the adoption and diffusion of digital innovations. Hackathons, site visits, peer-to-peer mentoring, online workshops and secondments serve to unleash the Kyiv School of Economics’ potential in three capacity domains: (i) contribution to ongoing methodological and empirical-analytical debates in the academic literature, (ii) bridging the knowledge gap with policymakers and professionals, and (iii) organisational capacity to sustainably secure grants and research funds for KSE’s ongoing organisational development, talent acquisition and preventing brain drain. For maximum effectiveness, KSE will apply acquired knowledge to a pilot study of digital recovery system DREAM and its participatory module eDem, including a design and assessment of a pilot digital citizen assembly on a municipal level.

Keywords: digital democracy ukraine algorithmic governance deliberation citizen participation
Building multidisciplinary evidence to support Integrating Malaria VACcine with Seasonal malaria chemoprevention in West Africa (IMVACS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Burkina Faso,Italy,France,Mali,United Kingdom
Call: Improving modes of delivery, deployment, and uptake of vaccines through phase IV/implementation research (HORIZON-JU-GH-EDCTP3-2023-02-two-stage, 2023)
Start date: 2024-12-01
End date: 2028-11-30
Duration (months): 48.0
Total project cost (EUR): 5736729.64
EU funding (EUR): 5736729.64
Participants: 5
Project status: SIGNED

Despite available efficacy data on two malaria vaccines designed for broad use, there is little evidence about scalable delivery strategies in areas with seasonal malaria transmission. We propose a multi-site, multi-disciplinary Phase IV cluster-randomized trial in Burkina Faso and Mali to evaluate the effectiveness, real-life impact, acceptability, feasibility and cost-effectiveness of a novel integrated delivery strategy of R21/Matrix-M in areas with highly seasonal malaria transmission.We will compare campaign-style vaccination co-administered during Seasonal Malaria Chemoprevention to vaccination following an age-based strategy in routine Essential Programme on Immunisation activities using a non-inferiority design. We will engage with all stakeholders to co-design the integrated strategy, collect malaria incidence data via surveillance and prevalence via cross-sectional surveys, generate data on coverage, assess feasibility and acceptability among stakeholders and end-users using qualitative longitudinal study methods, and describe the cost-effectiveness of both approaches, with costs and outcomes measured from the societal perspective. We will also use the trial platform to perform post-licensure pharmacovigilance of R21/Matrix-M. The project will ensure translation of results into policy and practice throughout areas of highly seasonal malaria transmission. It responds to SDG3, and is aligned with the Immunization Agenda 2030, particularly by testing a community-based vaccine approach that should reduce the number of “zero-dose” children. By leveraging the SMC platform, we hope to mitigate vaccine hesitancy. Our multi-disciplinary approach aims to generate a comprehensive package of evidence that will allow policymakers to make informed guidelines for malaria vaccine schedules and delivery in the Sahel, at the same time reinforcing health systems and promoting synergies between malaria and vaccination programs in support of the Primary Health Care agenda.

Keywords: malaria,vaccine,implementation research,cluster clinical trial
SEarChing REcent CrYomagmatism in Ceres and Europa, astrobiological targets (SECRECY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: SIGNED

The motivation of this project is to contribute to the search and characterization for potentially habitable planetary environments. During the two last decades, missions to the outer solar system, such as Galileo to the Jupiter system, Cassini-Huygens to the Saturn system and Dawn to the main protoplanets of the asteroid belt, have discovered several "ocean worlds". Jupiter’s moon Europa, Saturn’s moons Titan and Enceladus, and the dwarf planet Ceres, show signs that indicate the presence of liquid water in their interiors, potentially interacting with organic compounds and hot rocks. These "ocean worlds" are now considered as prime astrobiological targets by the major space agencies ESA and NASA. This project proposes a strategy to identify freshly erupted materials at the surface of these icy bodies and provide informations on their composition and on the subsurface source. Specifically, it is focused on Europa and Ceres, the most accessible targets for in-situ landing missions. For this purpose, we will experimentally study the processes that aqueous solutions of diverse compositions undergo from their emplacement in the interior of the crust at medium-high pressure and relatively low temperature, to their subsequent arrival at the surface at high vacuum and much lower temperature. Infrared and Raman spectroscopies and mass spectrometry instruments will be used to characterize the different processes from the source conditions to the surface emplacement and subsequent alteration. These techniques are within the science payload of past, current and future missions. Therefore, the data obtained in the laboratory will be used as public databases to assist in the interpretation of spectra taken on space missions.

Keywords: ocean worlds,cryomagmatism,icy material analogues,infrared and raman spectroscopy,mass spectrometry,space missions data interpretation