Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
New µ-CHP network technologies for energy efficient and sustainable districts (FC-DISTRICT)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Collaborative project
Countries involved: Poland,Greece,Spain,Germany,Netherlands,Sweden,Spain,Portugal,United Kingdom,Germany,Italy,Belgium,Germany,Romania,Italy,Belgium
Call:  (FP7-2010-NMP-ENV-ENERGY-ICT-EeB, 2010)
Start date: 2010-09-01
End date: 2014-08-31
Duration (months): 48.0
Total project cost (EUR): 11800888.7
EU funding (EUR): 8000000.0
Participants: 23
Project status: CLOSED

The overall objective of the FC-DISTRICT project is to optimize and implement an innovative energy production and distribution concept for sustainable and energy efficient refurbished and/or new “energy autonomous” districts exploiting decentralized co-generation coupled with optimized building and district heat storage and distribution network. The concept is based on dynamic heat exchange between the building(s) (fitted with Solid Oxide Fuel Cells (SOFCs) for energy production collaborating with improved thermal storage and insulation building systems), the distribution system (optimized piping and district heating with or without a heat buffer) and the consumer (new business and service models), aiming to achieve energy balance at district level. Advanced insulation materials will be developed and implemented for the improvement of building and pipe thermal response. The energy reduction will originate from improved efficiency and cost effective high temperature (SOFC), to act as micro heat and power cogeneration (μ-CHP) systems providing demand-flexible electricity and heat to the building and district, coupled with optimised energy and power distribution networks that will optimally control heat storage at building and/or district level. FC-DISTRICT integrates a proven innovative mid-term energy technology (SOFC) with heat management at building and district level (building thermal storage coupled with intelligent distribution networks) to serve the consumer needs for economy-ecology-sustainability. It introduces a new paradigm in energy efficiency by developing materials, technologies, methodologies and systems specifically intended for integration at district level.

Keywords: fuel cell,energy efficiency,district,solid oxide fuel cell,micro-chp,sofc,thermal network,micro-grid,heat,power,thermal storage,biogas
Knowledge, Awareness and Prediction of Man, Machine, Material and Method in Manufacturing (KAP)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Contribution of the ICT Theme to Public-Private Partnerships for R&D in the European Economic Recovery Plan
Action type: Collaborative project
Countries involved: Germany,Spain,United Kingdom,Germany,Spain,Greece,France,Germany,Italy,Sweden,Germany,Ireland,Spain,Spain
Call:  (FP7-2010-NMP-ICT-FoF, 2010)
Start date: 2010-09-01
End date: 2013-12-31
Duration (months): 40.0
Total project cost (EUR): 12577819.0
EU funding (EUR): 7448980.0
Participants: 15
Project status: CLOSED

Manufacturing is the driving force of Europe's economy, providing over €6,553 billion in GDP. However against a background of climate change legislation, volatile energy prices and increased environmental awareness, modern manufacturing must encompass a focus on eco-efficiency. Given the current economic situation, this must be achieved without the need for large capital expenditure. Adding information technology to an already existing production facility is a cost-effective investment. The KAP project will deliver energy management standards and a technology framework for next generation, sustainable manufacturing. KAP stands for Knowledge of past performance, combined with Awareness of the present state, which together can support Prediction of future outcomes. This philosophy forms the basis of a framework that will enable every existing resource to be used as efficiently as possible through the effective co-ordination of man, machine, material and method. To achieve this goal the project will define a range of sustainable manufacturing standards. Measurements will be gathered through a factory-wide network of sensors. Complex Event Processing (CEP) and data stream analysis will compute on-the-fly production performance indicators (PPIs) for real-time monitoring. Data mining in combination with OLAP will support problem diagnosis and resolution. Computational learning techniques will create a self-improving system for operational control. The inclusion of energy management makes the interpretation of system data an even greater challenge. Perceptually efficient visualisations will communicate PPI’s to decision makers in a format that will reduce cognitive workload and improve situation awareness. A well-balanced consortium of research centres, academic and industry partners provides an ideal opportunity to realise the innovations proposed by the project. In terms of impact, partners estimate reductions of over 5% p.a in waste and energy and 10% in time to market.

Keywords: energy,manufacturing,cep,kpi,data management,production,ppi,process optimisation,automotive,semiconductor
Intelligent Management System to integrate and control energy generation, consumption and exchange for European Sport and Recreation Buildings (SPORTE2)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Contribution of the ICT Theme to Public-Private Partnerships for R&D in the European Economic Recovery Plan
Action type: Collaborative project
Countries involved: Italy,Portugal,Italy,Spain,United Kingdom,Italy,Greece,Italy,Spain
Call:  (FP7-2010-NMP-ENV-ENERGY-ICT-EeB, 2010)
Start date: 2010-09-01
End date: 2014-08-31
Duration (months): 48.0
Total project cost (EUR): 4664310.0
EU funding (EUR): 2915850.0
Participants: 12
Project status: CLOSED

The European Sport and Recreation Building Stock accounts for approximately 1,5 Million buildings or 8% of the overall building stock. These facilities are unique by their physical nature, their energy consumption profiles, the usage patterns of people inside, ownership, and comfort requirements. SPORTE2 aims to manage and optimize the triple dimensions of energy flows (generation, grid exchange, and consumption) in Sport and Recreation Buildings by developing a new scalable and modular BMS based on smart metering, integrated control, optimal decision making, and multi-facility management. This tool will enable a new relationship and business model structure between facility managers and power providers. The SPORTE2 modules will be applicable to both new and existing structures and answer the fundamental questions of how, where, when and why energy is produced, used and grid exchanged. The approach will target a reduction of energy consumption by up 30%, with commensurate CO2 reductions and cost savings. The project will make use of a full scale building laboratory environment (Kubik) for system integration and testing. The project will then implement the SPORTE2 modules in three full-scale pilots representative of the sector (e.g. swimming pools, indoor and outdoor courts, gyms, etc) and able to implement the smart grid concept through the availability of RET and cogeneration devices. Strong linkages to sport associations and green building design are present in the consortium to enable exploitation of project results.

Keywords: sports centres,energy efficiency,energy conservation,smart grids,smart metering,smart buildings,energy saving,energy audits,energy benchmark,retrofitting
Flexible Compression Injection Moulding Platform for Multi-Scale Surface Structures (IMPRESS)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: New production
Action type: Collaborative project
Countries involved: France,Switzerland,France,Germany,United Kingdom,France,Germany,Germany,Portugal,Ireland
Call:  (FP7-2010-NMP-ICT-FoF, 2010)
Start date: 2010-05-01
End date: 2013-04-30
Duration (months): 36.0
Total project cost (EUR): 7038467.99
EU funding (EUR): 4616297.0
Participants: 15
Project status: CLOSED

IMPRESS targets the development of a technological injection moulding platform for serial production of plastic components incorporating micro or nano scale functional features. The platform will be based on the gathering of up to date and most advanced facilities based on three main modules, each of them being a tool box including several building blocks: - a tool manufacturing module involving different technologies of micro- nano direct manufacturing, from top-down to bottom-up such as self-assembling, - an injection moulding module including equipments fitted with up to date hardware to improve replication quality and capability, - an intelligence module dedicated to advanced process control and online metrology integration. Beside this large panel of facilities, three case studies have been selected (biology, health and energy), each of them requiring a specific and well defined surface micro-nano texturation. These case studies cover a very large range of nano-feature (from 100nm up to 1 µm) and component size (from 1 cm2 up to 1000 cm2). They will serve to qualify the capabilities of the different building blocks and will allow (i) to select the most suitable building blocks as of application requirements (ii) to learn about the platform working and (iii) to anticipate the technological future of the platform. Finally, a technico-economic tool for decision making will be developed based on the IMPRESS case studies and thus to allow end-users to select the most appropriate configuration regarding the end product manufacturing requirements. Further to the IMPRESS case studies, the performances of the platform will be validated through a satellite group. IMPRESS technological platform will accelerate the production and the time to market of micro nano-scale functional feature on multi-component devices in order to obtain an important reduction of needed supply chain space, technological risk and manufacturing costs of next generation plastic part products.

Keywords: injection molding,micro nano feature
Car multi propulsion integrated power train (CASTOR)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Contribution of the ICT Theme to Public-Private Partnerships for R&D in the European Economic Recovery Plan
Action type: Collaborative project
Countries involved: Germany,Norway,Italy,Germany,United Kingdom,Spain
Call:  (FP7-2010-ICT-GC, 2010)
Start date: 2010-06-01
End date: 2013-11-30
Duration (months): 42.0
Total project cost (EUR): 5315615.0
EU funding (EUR): 3400000.0
Participants: 7
Project status: CLOSED

The main objective of CASTOR is to integrate an innovative distributed propulsion system on fully electrical vehicles. Future electrical propulsion concepts demand more efficiency and less complexity with great functionality, high robustness and light weight and need to run in a wide ambient temperature range. CASTOR is aimed at: •Energy saving of 10 - 20% in respect to present propulsion systems •Cost reduction of about 25% (TBD) respect to present propulsion systems •Increasing the safety due to traction properties and improved integrability into drive applications •Mileage improvement of 15 -20% due to higher efficiency and less weight How these goals will be achieved: •Advancements in efficiency and safety by implementing a multi propulsion power train enabling novel driving functionalities based on the holistic understanding of propulsion and related energy conversion needs. •Integration of the energy storage with the propulsion unit advancing the current state-of-the-art. •Novel conversion topologies like direct power conversion and battery to motor phase alignments reducing the amount of active switching elements •Application of high efficiency control structures and modules in automotive technology ensuring robustness, reliability, drastically reduced maintenance and architectural simplicity •Distribution and delocalization of distributed propulsion systems in order to minimize energy consumption assuring the maximum safety of the vehicle •Development of smart electric system controls in order to improve propulsion and energy management and create an intelligent network on-board vehicle •Simplification of production chain for distributed propulsion systems through a drastic simplification of system architecture •The research need is not only based on the integration of the component functionalities but also considering a holistic approach for the thermal management especially related to the restricted operation temp. of Li-Ion batteries.

Keywords: electronic,vehicle,propulsion,system,energy,range,efficiency,robustness,weight,consumption
Long-term PHARMacovigilance for Adverse effects in Childhood arthritis focussing on Immune modulatory drugs (PHARMACHILD)

Framework: FP7 — Cooperation
Programme: Health
Destination: Other Actions across the Health Theme
Action type: Collaborative project
Countries involved: Netherlands,Italy,Germany,United Kingdom,Germany,Netherlands,Netherlands,Germany
Call:  (FP7-HEALTH-2010-single-stage, 2010)
Start date: 2011-04-01
End date: 2014-09-30
Duration (months): 42.0
Total project cost (EUR): 3924102.4
EU funding (EUR): 2973976.0
Participants: 9
Project status: CLOSED

Until the age of biotechnology, treatment options for children and adolescents with severe arthritis, inflammatory bowel diseases and other serious diseases with chronic inflammation were limited. Advances in understanding the pathophysiology of the inflammatory responses have led to the development of a new class of medications that are capable of inhibiting selectively the principal mediators of inflammation and tissue damage. The introduction of these new immunomodulators, which are collectively termed biologics, has opened a new era in the treatment of inflammatory diseases. Recent reports however suggest unexpected increases in adverse - or serious events -associated with the use of these biologics. PHARMACHILD aims to detect, assess and understand long term and short term side effects of the use of biologics by studying the pharmacovigilance in a large international cohort of patients with Juvenile Idiopathic Arthritis (children and young adults) in order to support regulatory decisions on marketing authorizations for these products. There is a clear need for a study that will enable the promotion of more effective and safer use of biologics in JIA as children and young adolescents represent an especially vulnerable patient group, JIA is the most common chronic disease of childhood treated with biologics, and data available from adults cannot be extrapolated to children. PHARMACHILD brings together leading European scientists in the field of infectious diseases, immunity, inflammation and oncology. Our network combines resources from international organizations and existing national registries. This combination will enable us to achieve the critical mass (in terms of expertise and resources) to identify the risk factors for developing adverse events, to elucidate the mechanisms involved in the adverse events (such as latent infection reactivation) and to develop methodologies for screening and predicting patients at risk.

Keywords: biologics,pharmacovigilance,large cohort,juvenile idiopathic arthritis,children and young adults
To the root of organ growth: the control of root meristem activity in Arabidopsis. (ROMA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Cellular and Developmental Biology
Countries involved: Italy
Call:  (ERC-2010-StG_20091118, 2010)
Start date: 2010-11-01
End date: 2016-10-31
Duration (months): 72.0
Total project cost (EUR): 1475999.2
EU funding (EUR): 1475999.2
Participants: 1
Project status: CLOSED

In animals, the formation and growth of new organs cease at the completion of development; in plants, the body is continuously built throughout the plant lifespan. In addition, in plants there is virtually no cell migration due to rigid cell walls: this provides a unique opportunity for dissecting the relations between pattern formation and final organ structure. Plant post-embryonic development takes place in localized regions called meristems. In the root of Arabidopsis thaliana, stem cells in the apical region of the meristem self-renew and produce daughter cells that differentiate in the distal meristem transition zone. To ensure root growth, the rate of cell differentiation must equal the rate of generation of new cells. Recent work of the proponent has shown that maintenance of the Arabidopsis root meristem size - and consequently root growth - is controlled by the interaction between two hormones in the meristem transition zone: cytokinin, which promotes cell differentiation, and auxin, which promotes cell division, and has unveiled the regulatory circuit underlying this interaction. Scope of this proposal is to clarify how the cytokinin/auxin interaction influences the activities of the entire root meristem, thus ensuring a balance between cell differentiation and cell division. In particular, the work proposed aims to: - Clarify how the cytokinin/auxin interaction is perceived in the transition zone to bring about synchronous differentiation of all cell files of the distal meristem. - Understand how the cytokinin/auxin interaction maintains a balance between cell differentiation in the (distal) transition zone and cell division in the (apical) stem cell niche. - Unveil other inputs and regulatory circuits that interact with the cytokinin/auxin regulatory circuit in controlling root growth. These goals will be achieved via the identification of genes involved in these processes. Hypothesis-driven experiments will allow verifying the role of candidate genes, and genetic and genome-wide approaches will allow identifying new genes. In these activities, we will take advantage of state-of-the-art techniques, including tissue- and cell-specific gene expression techniques, analysis of microarrays from cell lines isolated via cell sorter, light microscopy and confocal imaging techniques, as well as classic genetic, physiological and pharmacological approaches. The experimental results of these research lines will be integrated into computational models with the ultimate goal of describing the mechanisms of root growth and its control

Keywords: auxin,cytokinin,root meristem
A functional analysis of Listeria and Staphylococcus lipoteichoic acid (LISTA-LTA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: United Kingdom
Call:  (ERC-2010-StG_20091118, 2010)
Start date: 2011-01-01
End date: 2015-12-31
Duration (months): 60.0
Total project cost (EUR): 1483505.0
EU funding (EUR): 1483505.0
Participants: 1
Project status: CLOSED

This proposal aims to provide insight into the physiological function of lipoteichoic acid (LTA) in the two Gram-positive bacterial pathogens Listeria monocytogenes and Staphylococcus aureus. LTA is an essential component of the envelope in Gram-positive bacteria. While the chemical structure of this polymer was elucidated several decades ago, the key genetic determinants for its synthesis have been identified only recently. These genetic studies made it clear that LTA has a crucial function within the cell, as absence of LTA severely impairs bacterial growth; a cell that lacks LTA has an aberrant cell shape and does not form normal division septa, but the molecular mechanism underlying these defects is not understood. With the recently developed mutants in the LTA synthesis pathway, we can now begin to address these questions. It is particularly intriguing that the absence of LTA on the outside of the cell influences the function and localization of FtsZ, the key cytoplasmic protein involved in the cell division process. However nothing is known about the molecular mechanism that links these two fundamental cellular processes. Upon consolidating my research group and with the experiments outlined in this application, I propose to investigate the molecular mechanism that links LTA synthesis with other fundamental cellular processes such as cell division and regulation of cell shape, provide insight into the structure and function of key enzymes involved in LTA synthesis, provide insight into the link between LTA synthesis and membrane lipid turnover and its functional consequences and determine the role of LTA as anchor for cell wall envelope proteins.

Keywords: cell wall envelop lipoteichoic acid lipids cell division
Identification and characterization of primate structural variation and an assessment of intra-specific patterns of selection and copy-number variation (PRIMATESVS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Genetics,Genomics,Bioinformatics and Systems Biology
Countries involved: Spain
Call:  (ERC-2010-StG_20091118, 2010)
Start date: 2010-12-01
End date: 2014-11-30
Duration (months): 48.0
Total project cost (EUR): 1599999.2
EU funding (EUR): 1599999.2
Participants: 1
Project status: CLOSED

Structural variation and copy-number variant regions (CNVs) (including segmental duplications) are usually underrepresented in genome analyses but are becoming a prominent feature in understanding the organization of genomes as well as many diseases. Large-scale comparative sequencing projects promised a golden era in the study of human evolution, however, many genome regions, especially these complicated regions, are clearly not solved. Despite international efforts to characterize thousand of human genomes to understand the extent of structural variants in the human species, primates (our closest relatives) have somehow been forgotten. Yet, they are the ideal set of species to study the evolution of these features from both mechanistic and adaptive points of view. Most genome projects include only one individual as a reference but in order to understand the impact of structural variants in the evolution of every species we need to re-sequence multiple individuals of each species. We can only understand the origins of genomic variants and phenotypical differences among species if we can model variation within species and compare it to a proper perspective with the differences among species. The object of this proposal is to discover the extent of genome structural polymorphism within the great ape species by generating next-generation sequencing datasets at high coverage from multiple individuals of diverse species and subspecies, characterizing structural variants and validating them experimentally. The results of these analyses will assess the rate of genome variation in primate evolution, characterize regional deletions and copy-number expansions as well as determine the patterns of selection acting upon them and whether the diversity of these segments is consistent with other forms of genetic variation among humans and great apes. In so doing, a fundamental insight will be provided into evolutionary variation of these regions among primates and into the mechanisms of disease-causing rearrangements with multiple repercussions in the understanding of evolution and human disease.

Keywords: primate evolution,structural variation,segmental duplications,next generation sequencing,cnvs