Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Connectivity in the neural control of muscles in stroke patients. (NeuralCon)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The lack of objective and robust measurements of motor recovery is a general problem in stroke rehabilitation. After the ischemic event, the motor impairment is assessed using clinical scales that provide only a general overview of the patient’s conditions, without detailed information on the activation of the individual muscles and the pathological co-contractions. In recent years, the hypothesis that the coordination of multiple muscles is wired at the neural level in a synergistic way has received strong experimental evidence. Therefore, the possibility to better understand the recruitment of multiple muscles and use this information for the assessment of motor recovery is extremely relevant for stroke rehabilitation. The project NeuralCon aims to investigate the neural mechanisms behind the control of multiple muscles of the lower limb in healthy individuals and its degeneration in acute stroke patients. The project will address the characterization of the neural coupling between muscles using innovative signal processing approaches applied to the high-density surface electromiographic signals during voluntary contractions. From the electromiographic signals, we will extract information regarding the coupling between multiple motor neurons in different motor pools. The final aim will be the development of a new generation of biomarkers based on the concurrent neural activation of several muscles in the lower limb of acute stroke individuals. The project will combine expertise in several fields: neuroscience of human movement, clinical neurophysiology, stochastic signal processing and computational neuroscience. The NeuralCon project will produce substantial progress toward a better understanding of the neural pathways involved in the coordination of voluntary movements and its modifications in cerebrovascular diseases.

Keywords: rehabilitation,synergy,stroke,motor unit,multichannel,biomarker,motor neuron,computational neuroscience
Intelligent Recommendation Decision Technologies for Community-Driven Requirements Engineering (OPENREQ)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Austria,Germany,Italy,Italy,Finland
Call: Software Technologies (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 4511775.0
EU funding (EUR): 4511775.0
Participants: 9
Project status: CLOSED

Requirements engineering is a key activity in ICT projects: What are current user needs and what requirements satisfy them? How much effort would a requirement cost and in which release should it be delivered? Which requirements can be reused from similar projects? Are there hidden dependencies or inconsistencies? What trade-offs are acceptable for users and other stakeholders? A satisfactory, efficient answer to these questions is essential for the success for nowadays software projects. OPENREQ leverages modern recommender algorithms, semantic technologies and data-mining to provide intelligent, proactive support for stakeholders survey alternatives and make individual or group decisions. OPENREQ focuses on complex, community-driven ICT projects with various dependencies and stakeholders as in the Telecom, Transportation, and Cross-Platform-Software domain covered in our trials. We will develop, evaluate and disseminate a fully integrated open-source requirements management platform and a set of connectors with the following decision-making capabilities: Requirements Intelligence: monitors the actual software usage, collects stakeholders’ and users’ feedback (e.g. from social media), aggregates and visualizes this information as predictive analytics. Stakeholder’s Personal Recommender: implements advanced recommendation and machine-learning algorithms to assist requirements work, improve a requirement’s quality, estimate its properties or predict relevant stakeholders. Group Decision Support: enables the stakeholders’ participation, the resolution of preference conflicts, and the identification of consensus, e.g. during release planning. Dependency Management: semi-automatically identifies requirements dependencies, supports requirements reasoning and reuse of requirements knowledge. With the OPENREQ Interfaces, these capabilities will be integrated into stakeholders’ workflows and tools including requirements tools, issues trackers and collaboration tools.
Extremal Sparse Graphs and Graph Limits (ExtSpGraphLim)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Hungary
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 134239.2
EU funding (EUR): 134239.2
Participants: 1
Project status: CLOSED

This proposal focuses on two related families of problems concerning algebraic invariants of graphs, i.e., networks. On the one hand, we study extremal values of algebraic invariants, i. e., we propose to give lower and upper bounds for certain algebraic graph parameters in a given class of graphs like d{regular graphs. On the other hand, we study the behavior of algebraic invariants of very large graphs, more precisely we study whether for a certain graph parameter p(G) it is true that the sequence (p(G_n)) converges if the graph sequence (G_n) converges in some sense. The two families of problems are connected by the observation that many graph parameter does not achieve its extremal value on finite graphs, but on some infinite object which is the limit of finite graphs.

Keywords: extremal graphs,regular graphs,graph limits
Selective 20S proteasome inhibition for multiple myeloma therapy (20SInhibitor)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-04-01
End date: 2020-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Multiple myeloma (MM) is a cancer of plasma cells, that is incurable, and the second most common form of blood cancer. Proteasome inhibitors (PIs) are considered a mainstay in the treatment of MM and mantle cell lymphoma (MCL). Current drugs, based on PIs however, target the chymotrypsin-like activity of the 20S proteasome, and inhibit the activities of both the 20S and 26S proteasomes. Thus, it is possible that selective drug intervention specifically inhibiting only the 20S proteasomes will reduce toxicity, and minimize the deleterious side effects of the current therapeutic regimens. Our preliminary work revealed a family of 20S proteasome inhibitors, which we termed Catalytic Core Regulators (CCRs) that selectively target the 20S proteasome rather than the 26S complex. Based on sequence motif and structural elements of the CCRs we have designed an artificial protein that is capable of inhibiting the 20S proteasome. We anticipate that these findings will lead to the design of synthetic proteins, peptides or peptidomimetic compounds targeting cancer cells more specifically. This specificity will pose the compounds in an attractive light for using them in various therapeutic applications. What is exciting from the commercialization perspective, is that pharmaceutical research has switched to revisit the use of peptides as therapeutics. Pharmaceutical companies have seen the development of peptides as a promising direction to lower their risk position. Overall, peptide therapeutics have a 20% chance of receiving regulatory approval, a probability that is 50% higher than that for the approval of small molecules, which form the basis of so called traditional drugs. In the project, we will carry out actions, which will equip us with the sufficient IP protection strategy, business strategy, industry networks and initial contacts for taking the innovation out from the laboratory to next phase in developing therapy first for MM and MCL later on.

Keywords: 20s proteasome,26s proteasome,proteasome inhibitors,peptide based drugs,multiple myeloma
Stereoselective Synthesis of Atropisomeric Fluorophores for Asymmetric Photocatalysis (AtropFluoPhoto)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

Arylated heterocyclic systems, such as fluorophores, have a long history as a component in functional materials. They are extremely useful platforms for a broad application in material science, biological imaging or organic synthesis, owing to their unique chemical, photophysical, and electrochemical properties. The development of an efficient route to prepare this type of heterocycles continues to attract interest for various applications, while only limited to the synthesis of symmetric fluorophores in racemic fashion. Introducing a chiral element into the molecules is of great significance for drug discovery, the design of catalysts for asymmetric synthetic photochemistry and other enantioselective methods. The resulting fluorophore bearing enantiospecific sensing platforms may also find potential applications in the enantioselective recognition of chiral small molecules or bioactive compounds such as DNA. Hence, the aim of the proposed AtropFluoPhoto is to develop a strategy for the asymmetric catalytic synthesis of chiral heterocyclic fluorophores. We plan to investigate different activation modes, such as chiral Brønsted acid and anion-binding catalysis, to achieve the construction of axially chiral fluorophores in intramolecular or intermolecular reactions. With the knowledge of their unique chemical and photophysical properties, we will then particularly explore their practical application in synthesis and novel catalyst design for asymmetric catalysis in photocatalysis. The proposed research will greatly broaden the fellow´s competencies and help him reach the professional maturity for a future academic career.

Keywords: catalysis,organocatalysis,asymmetric catalysis,organo fluorophores,helicenes,photocatalysis,axial chirality,ion pairing catalysis,chiral phosphoric acid
Efficient 5G Localization, Tracking, and Environment Mapping for Systems of Autonomous Vehicles (5GTRACK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2022-05-01
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

The automobile industry is fast moving towards commercializing autonomous vehicles (AV) after 2020. An important component of AVs is localization; a process by which the location of an AV is estimated, for which the industry is relying on high cost and computationally expensive technologies. 5GTrack aims to fill this gap by devising localization methods using 5G millimetre-wave (mmWave) communication technology, which have the potential to provide cm-level accuracy. Since AVs will be equipped with 5G communication technology anyway, integrating localization with 5G communication would provide an affordable and accurate localization solution. In a close interaction with local industry (Vovlo, Ericsson, Zenuity, Autoliv), the objective of 5GTrack is, firstly, to provide an integrated low-cost high-accuracy localization and tracking solution for near-static and highly-dynamic scenarios with a max error of 20 cm to serve vehicles, infrastructure, and vulnerable road users. Secondly, based on the reflective and scattering nature of the mmWave channel, 5GTrack also investigates methods of environment sensing to create a map of the vehicle surrounds that can be stored for future use. 5GTrack has 3 WPs, each will be achieved in 3 steps: 1) Modeling and performance requirement that will be discussed with the relevant industry, 2) theoretical analysis and 3) validation via computer simulation. Hosted by a highly dynamic, international, and intellectually stimulating department, 5GTrack will provide the ER with a great opportunity to interact with world class industrial partners, who work on cutting edge vehicular and communication technologies. This will boost his market competitiveness in a domain that will witness high growth in the future by giving him hands-on experience in the industrial requirements and methodology, as well as relevant software packages. It will also give the ER an opportunity to lead and industrial and academic innovation and patenting process.

Keywords: 5g communication,millimeter wave,localization,tracking,v2v and v2i communication,autonomous vehicles
Developing Rapid Inquiry as a pedagogical framework for multimodal interactions in informal science settings (SCIENCE-MINQ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2022-03-11
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

This project is firmly situated within the Learning Sciences – the interdisciplinary field that aims to further scientific understanding of learning and engage in the design and implementation of learning innovations; focusing on the area of Informal Science Learning – the study of science learning processes and outcomes in informal settings such as science centres. Bell et al. argue that a key challenge for science centres is to enable their visitors to link their emotional, sensory and cognitive interactions with the exhibits – known as multimodal experiences – to science-specific phenomena. This research aims to utilise the structure provided by inquiry-led scientific investigations to harness the engagement power of multimodal exhibits in science centres. To achieve this aim, we will work with science centre educators, science teachers and young people (aged 12-16) to: co-design a Rapid Inquiry framework; elicit user requirements; co-design interaction components that integrate multimodal interactions with exhibits; develop an Inquirer app and evaluate its impact; and develop a set of technical requirements and pedagogical guidelines that will enable science centres to adopt rapid multimodal inquiry as a pedagogical approach. Partnerships with science centres in the UK, local secondary schools and after-school science clubs will be established to secure maximum practical value and dissemination.

Keywords: science centres,science learning,informal learning,inquiry learning,multimodal learning,pedagogy,mobile learning
Destination cilium: towards selective probing and perturbation of ciliary signaling (DestCilia)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1408776.0
EU funding (EUR): 1408776.0
Participants: 1
Project status: SIGNED

The primary cilium is a microtubule-based organelle that organizes a variety of cellular signaling pathways. Its importance for human health is illustrated by a large collection of cilium-based diseases, the ciliopathies, caused by mutations that alter cilium formation, structure, and function. Importantly, the mammalian Hedgehog signaling pathway is critically dependent on the primary cilium, dysregulation of which contributes to severe developmental defects and a variety of cancers. The ultimate goal of this work program is to enhance our understanding of the molecular mechanisms of ciliary signaling in health and disease. This is accomplished through the development of advanced technologies that provide a currently unattainable level of spatiotemporal control over ciliary proteins in mammalian cells. Unraveling the mechanisms by which the ciliary compartment orchestrates signal transduction is challenging, because ciliary and cytoplasmic roles of proteins involved in signal transduction are tightly connected, difficult to resolve and, importantly, context-specific. Here, an innovative chemical biology program is presented that provides a powerful toolbox to overcome these challenges, allowing the intraciliary manipulation, and therefore study, of ciliary proteins. Combining chemical probes, synthetic ciliary targeting approaches, and a modular enzymatic tagging strategy, this program provides unprecedented opportunities to probe, visualize, inhibit or degrade proteins at specific times and selectively within the ciliary compartment. Specifically, these tools will be used to decipher the relationships between tubulin acetylation state, intraflagellar transport, and Hedgehog signal transduction in wild-type and ciliopathy-mutant cells. These innovative work packages synergistically provide enhanced fundamental understanding of ciliary signaling, and pave the way for novel therapeutic approaches to combat cilium-based diseases.

Keywords: primary cilium,hedgehog signaling,chemical probes,protein tagging,sortase a mediated ligation,ciliary targeting sequence,tubulin acetylation,atat1,intraflagellar transport,spatiotemporal control,ciliopathies
Universal and compatible system for plumbing and heating (HTPush)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2014, 2014)
Start date: 2015-04-01
End date: 2016-11-30
Duration (months): 20.0
Total project cost (EUR): 1628900.0
EU funding (EUR): 1140230.0
Participants: 3
Project status: CLOSED

Current trends in the global construction market show a scenario in which sustainability and modularity are the predominant concepts. These trends are shifting the value chain of this sector towards economic, strong, fast and versatile construction systems. In this line, accessories for quick connection of pipes (fittings), known as push-fit fittings, have great advantages over conventional ones. However, their use is limited because they are neither universal (usable for any kind of pipe) nor compatible (valid to be used with pipes of any manufacturer). At Hita Technology of Plastics Systems, S.L. we aim to develop and commercialise a complete family of push-fit fittings and flow regulators (HTPush) for potable water, plumbing heating, floor heating and radiator systems, intended to remove current shortcomings, offering end users a comprehensive solution to build complete installations to transport fluids from the general water network to the discharge point regardless from the pipe material and/or its manufacturer. These accessories will be developed (in line with topic NMP-25) making use of advanced polymeric materials, and novel and exclusive manufacturing methods. It will also based on a new, patented technology developed by our company (WO/2014/072539). Through this development our company expect introduce an innovative product into the market carrying out exploitation and diffusion activities during the project. As a result, it is expected an important growth for our company reaching a 2,4% market share, multiplying our sales by 10 and obtaining a total profit of 12,5 M€ in H2020. Also it is expected an induced benefit for UE, 42,75 M€ reached in H2020, derived from savings for end users, energy and waste savings and benefits from exportation.

Keywords: push fit,fitting,flow regulator accesories,advance manufacturing,polymeric materials