Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Evolvable platform for programmable nanoparticle-based cancer therapies (EVO-NANO)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Finland,Poland,Serbia,United Kingdom,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2018-10-01
End date: 2022-03-31
Duration (months): 42.0
Total project cost (EUR): 2988658.75
EU funding (EUR): 2988658.75
Participants: 7
Project status: CLOSED

EVO-NANO aims to create an integrated cross-disciplinary platform for the artificial evolution and assessment of nanoparticle-based drug delivery systems. Nanoparticles (NP) are increasingly being studied in cancer research for their ability to improve diagnosis accuracy and/or deliver tailored treatments directly to tumours. However, their effective biodistribution is still a major limitation. The challenge is to discover how to program collective behaviour of the trillions of NP interacting in a complex tumour environment. Finding effective NP designs that give rise to desired outcome will require a new class of evolutionary algorithms that can simultaneously 1) generate novel NP-based anti-cancer strategies, 2) search over a large space of solutions, and 3) adapt to a wide variety of scenarios. Our novel evolutionary approach will be integrated with molecular dynamics simulations, PhysiCell (http://physicell.mathcancer.org) and STEPS simulators that reproduces realistic NP motion and interactions within the tumour environment and with other NP. The most promising NP designs will then be synthesized and tested in vivo and in vitro on breast and colon cancer stem cells using mouse cancer xenografts and microfluidic testbeds featuring cancer microenvironments. To promote translation of the platform from early stage research into a commercialized product for patients, we will work with industrial partner ProChimia Surfaces, organize ‘Industry Open Days’ for potential investors and develop a translation strategy. EVO-NANO is a multidisciplinary project that will create an entirely novel NP design platform for new cancer treatments, capable of autonomously evolving both innovative and adaptive solutions. The proposed platform has the potential to be at the forefront of cancer nanomedicine by enabling much faster development and assessment of new cancer treatments, than is done today. The project will generate concrete tools for the predictive design of nanomedicines that could be applied in other clinical fields.

Keywords: cancer,cancer stem cells,nanoparticles,evolutionary algorithms,unconventional computing,drug delivery system,microfluidic cell chips,colon cancer,breast cancer
Medieval Irish and Medieval Icelandic Texts in Nineteenth-Century Translation (MIRMINT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Iceland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 184239.36
EU funding (EUR): 184239.36
Participants: 1
Project status: SIGNED

The project 'Medieval Irish and Medieval Icelandic Texts in Nineteenth-Century Translation' (MIRMINT) is a comparative study of translations of medieval Irish and Icelandic texts published by antiquarians in Ireland, Iceland, and Denmark in the nineteenth century. This period saw both scholars and cultural and political nationalists in several countries reflect on their respective national medieval pasts and what relevance it could have to the contemporary political situation. This, in turn, led to the adoption of so-called 'Golden Ages' - a point in time which was deemed to embody all of the characteristics which the envisaged national ideal held. Key to the adoption and perpetuation of the golden age were the translations of medieval texts from this designated period which made these works accessible to a larger audience. The project will answer the following three questions: What texts were translated? What does the choice of these texts tell us? What are the links between the texts and cultural nationalism? This will be achieved by compiling a database with a list of publications which will be crossreferenced against another list of medieval texts known to antiquarians in the nineteenth century, and by researching antiquarian correspondence and nationalist periodicals. This study will centre and promote the role of the small nation in the nineteenth-century context of empire, exploring how the past was used to argue for cultural and linguistic distinction, which, it was hoped, would lead to greater political autonomy. It will also investigate how the dominating countries, in this case, Britain and Denmark, also shared an interest in the Irish and Icelandic past, though they had different motivations for engagement with antiquarian research. The research is highly topical at a time when white nationalists associated with the Alt-Right have centred the middle ages to further their arguments, frequently focusing on the imagined Irish and Nordic pasts.

Keywords: antiquarianism,nineteenth century,ireland,iceland,denmark,medieval literature,translation,empire,cultural nationalism,nationalism,historiography
MID-IR Integrated Photonic Sensor for Health and Environment (MIRIPSHE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

MID-IR Integrated Photonic Sensor for Health and Environment (MIRIPSHE) address the growing demand for a CMOS compatible Mid-infrared (MIR) wave band photonic sensor. MIRIPSHE aims to achieve this goal by integrating rare earth doped chalcogenide glass into a silicon platform in order to exploit the superior optical and electronic properties of these two materials, respectively, for unparalleled bio-chemical sensing for health and environmental monitoring. The MIR band is an excellent detection window for most bio-chemical elements such as Amides, Lipids, Nitriles and Carbon dioxide as the absorption fingerprints of these molecules lies in the 3-10 µm wavelength range. Integrated Photonics platform can play a major role in the MIR on-chip chemical and biological sensing with high sensitivity. The progress of current MIR platforms to a complete lab-on-chip system is limited due to their incompatibility to monolithically integrate with a CMOS platform. MIRIPSHE strives to ingeniously develop a CMOS-compatible MIR optical sensor platform and a pilot demonstration of liquid phase Nitriles/Alkynes pharmaceuticals detection in the 4-5 µm region by functionalizing rare earth enriched chalcogenide glasses into silicon substrate using the novel ultrafast laser plasma implantation (ULPI) technique developed at the University of Leeds (UNIVLEEDS). The sensing scheme relies on the MIR fluorescent emission of rare earth elements and their selective absorption characteristics corresponding to the molecular composition of the analytes. This ambitious project in the emerging technologies is perfectly suited to a Fellow with a strong background in Opto-electronics research and CMOS industry. The Fellow, Jayakrishnan Chandrappan, is one of the unique candidates having vast industrial experience both in optoelectronics device development and 300 mm silicon wafer processing. He recently moved to University of Leeds to pursue his interest in academic research, transferring the

Keywords: mid infrared,integrated photonics,silicon,cmos,ultrafast laser processing,waveguides,rare earths,chalcogenides,optical sensor
Active & intelligent PAckaging materials and display cases as a tool for preventive conservation of Cultural Heritage. (APACHE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Italy,Ireland,Italy,Italy,Italy,Germany,Germany,Italy,Greece,Slovenia,Sweden,Sweden,Hungary,Greece,Belgium,France,United States,United Kingdom,Brazil
Call: Innovative and affordable solutions for the preventive conservation of cultural heritage (IA) (H2020-NMBP-ST-IND-2018, 2018)
Start date: 2019-01-01
End date: 2022-06-30
Duration (months): 42.0
Total project cost (EUR): 7873590.9
EU funding (EUR): 6837732.75
Participants: 29
Project status: CLOSED

Most Cultural Heritage objects housed by museums are often stored under unsuitable climate conditions. APACHE will develop a cutting edge technology to control and prevent the degradation of such patrimony. The novel approach is based on three pillars: 1) advanced sensing and absorbing materials to control the artifacts’ environment; 2) modeling to define the threshold of artifacts’ degradation and to discriminate between the need for preventive or remedial conservation; 3) remote control of the works of art stressors. The unique combination of these pillars will reduce to the lowest possible level the costs actually required by conventional technology for art conservation. New generation of active and intelligent display cases, crates, and storage boxes, will be implemented thanks to: i) The unique APACHE partnership, comprising the most important experts in the three aforementioned pillars; ii) The development of easy-to-use sensing devices able to communicate through Wireless Sensor Networks and Radio Frequency Identification Devices thanks to Industry 4.0-5.0 ICT technologies, granting the optimal environmental conditions around the art objects. Multiscale models integrated in an open simulation environment will be used to predict the degradation of artefacts and set the properties of sensors (detection limits) and polyfunctional absorbents. APACHE includes small, medium, and large museums exhibiting representative variety of display and storage conditions. For instance, the Venice Peggy Guggenheim Collection features one of the most important collections of modern/contemporary art, which experiences highly unfavorable environmental conditions, difficult to control with conventional tools. Centre Pompidou and National Museum of Hungary possess a vast amount of artefacts stored in deposits (e.g. in crates and boxes). Moreover, a decision-making tool composed by a modular set of decision trees will be offered to end-users to guide them through the best solutions.

Keywords: preventive conservation,artefacts in storage,display,multi scale modelling,chemisorbents,sensors,packaging materials,display cases,wireless networks,radio frequency identification devices
Regulating Vehicle Access for improved Livability (ReVeAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Italy,Israel,Spain,Germany,Germany,Italy,Germany,Belgium,Sweden,Belgium,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Harnessing and understanding the impacts of changes in urban mobility on policy making by city-led innovation for sustainable urban mobility (H2020-MG-2018-TwoStages, 2018)
Start date: 2019-06-01
End date: 2022-11-30
Duration (months): 42.0
Total project cost (EUR): 3942067.5
EU funding (EUR): 3942067.5
Participants: 15
Project status: SIGNED

Despite urgent calls for “smarter urban vehicle access regulations” in the Urban Mobility Package and other high-level political commitments, very few decision makers are keen on going public with the idea of restricting car access (in time or space) in urban areas. ReVeAL will help to add Urban Vehicle Access Regulations (UVAR) to the standard range of urban mobility transition approaches of cities across Europe. Toward this end, the ReVeAL consortium will combine conceptual work and case study research with hands-on UVAR implementation in six pilot cities and systematic stakeholder interaction and professional communication activities. The pilot cities of Helmond, Jerusalem, London, Padova, Vitoria-Gasteiz and the project leader Bielefeld are committed to developing, implementing, testing and evaluating UVAR measures in one or more of four “Measure Fields”: 1) Zero Emission Zones, 2) Spatial Interventions, 3) Pricing Measures and – through a process called “sandboxing” – 4) some innovate Future Options (C-ITS, geo-fencing etc.). ReVeAL considers the implementation of UVAR measures a necessary part of a wider transition management challenge and therefore ensures comprehensive and coordinated changes to multiple elements of the urban transport system. Most prominently, these aspects fall into four “Transition Areas”: Governance and Financing; User Needs/Acceptance; Mobility Concepts; and System Design/Technology – all of which play a role in any change process. With its built-in mechanisms to accompany, document and analyse the processes and impacts in the six pilot cities, ReVeAL will be able to systematically extract lessons learned and thus support the wider roll-out of smart UVAR approaches across Europe. A key strategy towards this goal is the provision of practical decision support tools and advice on the integration of UVAR in SUMPs. ReVeAL will result in an online Decision Support Tool, which includes a UVAR Readiness Assessment and a UVAR Process Advisor.

Keywords: uvar,access regulation,zero emission zone,superblock,transition,governance,user needs,acceptability,technology,readiness assessment,process advisor,livability,mobility concepts,urban
Genetics of Individuality (IndiGene)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Germany,United Kingdom
Call: ERC Synergy Grant (ERC-2018-SyG, 2018)
Start date: 2019-02-01
End date: 2025-07-31
Duration (months): 78.0
Total project cost (EUR): 6272613.0
EU funding (EUR): 6272613.0
Participants: 4
Project status: SIGNED

We propose to thoroughly investigate and characterise the sources of variation that results in varying phenotypes in a complex vertebrate. As well as characterising the genetic and environmental sources of variation, we will also investigate individual stochastic variation present even in fixed settings (both genetically and environmentally). To achieve this we will exploit the unique properties of Medaka fish, which can be fully inbred from the wild. We have already inbred and performed whole genome sequencing of a panel of 111 diverse Medaka fish from a single location; we propose to phenotype these fish in depth with high replication structure, ranging from organismal to molecular phenotypes. We will also phenotype entirely wild fish from the same source population as the panel with a subset of the phenotypes. We will analyse the data using state of the art methods to partition variation between genetic, environmental and stochastic components, and their interactions. We will integrate across both the different levels of phenotypic information across the cardiovascular system, and also across vertebrate phenotypes, in particular the extensive human phenotypes. By using genetic crosses and CRISPR-Cas9 techniques we will definitively prove specific interactions. We will host a “Research Hotel” for other phenotyping schemes to be applied to this panel, in particular from the Zebrafish community. This comprehensive and carefully replicated study will allow us to understand the opportunities and limitations of genetic stratification and personalised medicine in humans.
Blood Samples and DNA-an Innovative Technique for Lung Cancer Diagnostics (Lung EpiCheck)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-11-01
End date: 2021-04-30
Duration (months): 30.0
Total project cost (EUR): 3509375.0
EU funding (EUR): 2456562.5
Participants: 1
Project status: CLOSED

Nucleix has developed a highly innovative process for cancer diagnostics. The company plans to introduce Innovative Technique for Lung Cancer Diagnostics via identification of changes in DNA Methylation in Blood Samples. The company has already introduced successfully the Bladder EpiCheck and gained experience in the process of: clinical validation, regulatory approvals and commercialization of bladder cancer diagnostic of cancer via identification of changes in DNA Methylation. Nucleix’s current technology of lung cancer detection in blood samples – Lung EpiCheck - was developed using the same technology and team which has successfully developed Bladder EpiCheck. Nucleix breakthrough innovations are in the area of cancer detection using a unique combination of a best-in-class biochemical tool, combined with advanced big-data bioinformatics analysis. Lung EpiCheck is a high-potential innovation idea and though having some risk in the process of market adaptation it creates a very high commercial opportunity for Nucleix for growth and a successful mature enterprise At present, lung cancer is usually detected at late stages, where survival rates are very low – about 15%. The reason for this is that lung cancer patients are mostly asymptomatic in early stages. Detecting lung cancer in early stages significantly improves survival rates to 50% to 80%, thus a good tool for lung cancer detection has huge potential. The current high clinical results of Lung EpiCheck and the meetings with European potential customers (such as leading medical centers and lab chains) shows that the project proposed methodology and the expected performance is very promising to potential customers and market leaders. These potential customers have also confirmed company’s assumption about pricing that provides proper value for money. Nucleix’s technology is expected to create a huge value proposition to patients, physicians and payers identified as the main stakeholders

Keywords: cancer,lung cancer
EXtreme upper TAil of SEA level rise: constraints from geological records (ExTaSea)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-01
End date: 2022-02-28
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Sea-level rise is a major societal concern, with potential impacts on population, infrastructure and coastal environments. Coastal defence and adaptation strategies are highly dependent upon our ability to understand and predict sea-level variability, including extreme sea levels. Quantifying the upper tail probability of sea level – i.e., the risk of extremes - is therefore of high socio-economic relevance. Current projections suggest a low probability of polar ice-sheet decay scenarios, but they cannot be ruled out. Such scenarios are poorly parameterized and/or associated with large uncertainties in current projections. The ExTaSea project will address two sources of uncertainty in current projections of future sea-level: (1) our understanding of the system and, (2) the degree to which we can simulate natural variability. ExTaSea will do this by producing well quantified natural bounds on both the rate and magnitude of sea level rise (objective 1) and probability distributions that include specific information on high-end extremes for global mean and regional sea levels (objective 2). These will contribute to our understanding of these sources of uncertainty and will form the basis for policy-relevant extreme sea-level scenarios (objective 3) that account for the dynamic response of the ice sheets to climate forcing. ExTaSea will produce statistical distributions by: (1) collating and quality checking already available geological data from past time intervals of the last 200,000 years that are useful analogues for future change; (2) novel statistical techniques (e.g., modified Bayesian partition modelling) and (3) modelling of solid Earth deformation processes (GIA) that will allow absolute magnitudes of sea levels to be determined. As the geological record integrates all processes, the statistical distributions on the natural bounds of sea-level will include the high-impact (extreme) tail associated with mass loss from the polar ice sheets.
Cross-layer resilience for rack-scale disaggregated memory (SHEPHERD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Cyprus
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2024-12-30
Duration (months): 24.0
Total project cost (EUR): 145941.12
EU funding (EUR): 145941.12
Participants: 1
Project status: SIGNED

Data-intensive applications, such as search, social connectivity, and e-commerce, are increasingly relying on computer memory for storing and processing a large amount of data with low latency. Emerging disaggregated memory meets this growing demand by leveraging recent technology advances in high-density, byte-addressable non-volatile memory and low-latency interconnects to provide a large memory pool shared across micro-server compute nodes. With a larger memory density and capacity though, memory errors will become more frequent. Addressing such errors becomes paramount as they can cripple service availability and cause data loss. However, established hardware techniques for tolerating memory errors transparently to application software, originally developed for DRAM-based main-memory systems, become impractical at the scale of disaggregated memory due to increasing performance, energy and area overheads. This research will investigate and develop cross-layer memory resilience techniques where software and hardware work together cooperatively to prevent service unavailability and data loss due to memory errors in disaggregated memory with low overhead. It capitalizes on the existing strengths of the experienced researcher (ER) in the area of system software design for non-volatile memory and expertise of the host on memory fault tolerance and micro-server architectures. It will lead to several publications in top-quality venues and will inform forthcoming industrial efforts to develop resilient disaggregated memory micro-server architectures, thus contributing to the research output, visibility, and economy of Europe. Overall, the fellowship will give the ER the opportunity to reintegrate into a long-term academic position in Europe, after a long and fruitful research career in the academic and industrial sectors of the United States. The ER will emerge from the project with new skills and the capability to effectively lead his own research group.

Keywords: rack scale architectures,non volatile memory,disaggregation,fault tolerance,hardware,software codesign