Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Regenerative medicine for cost- and time-efficient pet treatment (Vetherapy)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Portugal
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

There are a number of different veterinary diseases for which current medicine (surgical techniques and drugs) offer absolutely no solution like osteoarthritis and neurological, autoimmune and inflammatory diseases. Today, the treatment of these disorders could get benefit from the administration of stem cells. At Vetherapy we provide stem cell therapies and regenerative products for veterinary application, in an easy, ready-to-use, and affordable manner. We have used our knowledge and experience to develop a whole set of products that use stem cells and stem cell’s derivatives to a variety of scenarios, from injury to degenerative disorders. The secret of our success is based on an innovative technology that allowed us to overcome one of the major difficulties of the application of stem cells: cell viability. Our technology extends cell viability up to 48h (vs. 4-6h of current methods) and enables the delivery of a ready-to-use high quality product, anywhere within this time frame. Following very promising pre-clinical results where we tested the safety and efficacy of our product, we now plan to commercialize our inventions PET-STEM and WOUND FIX® by optimizing their design and carrying out a large veterinary clinical trial. The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of PET-STEM and WOUND FIX® and their market uptake.

Keywords: stem cell therapy,regenerative product,veterinary
The influence of periodicals and their editorial contexts on scientific discourses of the Arctic, 1789-1914. Or: How the Arctic became Epistemological Space (HAES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-04
End date: 2023-01-03
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

As the Central Arctic Ocean’s ice melts, the Arctic region is attracting more and more attention from countries around the globe, including European states. To understand the risks and potentials of the Arctic ice melt, governments depend on scientific research. The more the Arctic becomes the focus of European and world-wide governments, economies and socio-cultural endeavours, the more the communicational infrastructure that carries scientific findings and knowledge on this region needs to be reliable and robust. This action aims to further a central element of this infrastructure—namely the scientific journal. This action approaches today’s scientific journals on Arctic research in a novel and innovative way: through the transnational study of historical scientific journals of the long nineteenth century (1789-1914). As human-made artefacts, science journals have mirrored political, economic and socio-cultural forces since their very beginnings—and this action’s aim is to investigate how exactly these forces have shaped editorial contents and contexts. More concretely, this is an investigation of both the editorial contexts and contents of articles related to the Arctic that appeared in scientific journals within the geographical area that today is home to Austria, the United Kingdom, Germany, Poland, Russia, Switzerland and the United States. If we understand how editorial processes formed earlier journal-based discourses on the Arctic, we can compare them to their counterparts of today, consider their strengths and weaknesses and take editorial action to bolster current scientific discourses on the north polar region. This action aims to do so by bringing together history of science, media history, Arctic research and historical geography. Moreover, by way of two strategic Secondments, the action seeks to translate its findings into practical commentary and editorial suggestions for today’s science journals on north polar research.

Keywords: long nineteenth century,editorship,journals,communication instrument,discourse,science,circumpolar arctic
ReCoN-nect - The Green Deal: Research communication to CommuNities (ReCoN-nect)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Romania,Romania,Romania,Romania,Romania
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020bis, 2020)
Start date: 2021-04-20
End date: 2022-05-19
Duration (months): 13.0
Total project cost (EUR): 149550.0
EU funding (EUR): 133550.0
Participants: 13
Project status: CLOSED

Societies underinvest in research either because it is a long term process and the results are not easily seen, either because of the complexity of this enterprise. This along with other difficulties weighs on the researchers who lack the will or power to get more engaged in the public life which further affects the trust in science and research. Breaking the vicious circle is a slow process and should be based on a genuine partnership between the researchers, as promoters of new findings about the world's true nature, the society as a whole, with its most stringent but also subtles needs, and the communication facilitators as a way to surface the unexpressed realities. The partnership, ReCoNnect-ing these different views, should be effective in educating the present citizens, but also shaping the teaching approaches for the members of the future society. This consortium is made up from 6 research institutes, 4 universities, 1 public body, and 2 civil community associations experienced in promoting science and STEM education, which supported the development of one of the largest educational networks in the country in connection also with EU programmes. Together, we propose a highly innovative concept of European Researchers' Night rooted in a long experience with the programme and well supported by the partner's institutions, which we will implement in a nationwide campaign comprising 21 events in representative urban areas. Three UNESCO/aspiring geoparks will organize events in rural areas, while others will be encouraged to participate remotely. Focusing the conversation, we tackle a topic of great interest for the European Union countries: The European Green Deal. We propose to map the current perceptions and expectations of the population on this programme by a large number of encounters with the public, and to better communicate on the endeavors and successes that Romanian researchers have in contributing to the very ambitious goals of the EU programme.
Friend to understand (Friend2U)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Serbia,Serbia,Serbia
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-05-01
End date: 2015-12-31
Duration (months): 20.0
Total project cost (EUR): 112700.0
EU funding (EUR): 98000.0
Participants: 6
Project status: CLOSED

Our mission of exposing the researchers as ordinary people with an extraordinary job to the public at large in Serbia started in 2010. Annual impact assessment reports show that we significantly influenced the perception and knowledge of the general public regarding WHAT the researchers do, but they also showed that there is room for improving the ways of showing WHO the researchers are, by making the personalities and faces of the researchers recognizable to the society, as well as in clarifying WHY they become researchers, i.e. their motivation and inspiration to explain why research matters to society. Therefore, without losing a focus on WHAT, RN 2014-2015 will focus on the questions of WHO and WHY in order to offer a new dimension of perceiving the researchers and offer more answers beyond the WHAT question. Friend2U - Researchers’ Night project aims at bringing the researchers closer to the general public and increasing awareness of the research and innovation activities with a view to supporting the public recognition of researchers, creating understanding of the impact of the researchers' work on our daily life, and encouraging young people to embark on scientific careers. In other words, it aims at increasing mutual understanding, interest and connections, and facilitating a dialogue between the researchers and the general public. In a nutshell, it is about making the researchers friends with the common people i.e. the general public - as closest friends as possible. Friend2U project proposal mixes, blends and unites faces, voices, results and energies of many generations of the researchers in offering the public at large, regardless of their age, education and scientific background, the opportunity to make friends with these researchers. Here, making friends with the researchers is a paradigm of learning more about their science, learning how to appreciate their work and achievement, and above all, about building trust in what friends do and invessuccessful implementation fot eh ation and as such needs to be udnertaken weell before sumemr break.

Keywords: friendship,faces of science
VALidation of human PApilloma virus assays on Self-collected first void urine samples (VALPAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Belgium
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-09-01
End date: 2015-10-31
Duration (months): 2.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Annually, about 13,000 women in the EU28 and 266,000 worldwide decease of cervical cancer caused by the human papilloma virus (HPV), thereby ranking third most common cancer worldwide . Throughout Europe, cervical screening programs are organized by local governments to detect cervical cancer at an early stage. Importantly, HPV-based screening (instead of cytology-based screening) is being implemented worldwide. However, a global challenge is that about 40% of women in the EU do not participate in these screening programs and are thus at-risk for development of cervical cancer. To reach these non-attendees, home self-sampling devices can increase the participation rate. The innovative Colli-PeeTM device developed by Novosanis offers a non-invasive, user-friendly solution. The device is suited for collection of first void urine (first 20ml of the urine flow) which allows for detection of HPV DNA. The Colli-PeeTM device thereby offers a novel innovative approach towards HPV-based screening. The VALPAS (VALidation of human PApilloma virus assays on Self-collected first void urine samples) project aims to successfully launch the Colli-Pee first void urine collection for HPV DNA testing in the EU28 and global market. The feasibility assessment in phase I aims to explore strategies with regard to market penetration & growth, competitors, pricing & reimbursement, partnerships, revenue models; ultimately leading to a business plan for Colli-PeeTM-based HPV screening. Specifically, phase I entails: - Market segment analysis - Competitor bench marking - Initiation of partnerships with diagnostic companies & labs - Exploration of pricing & reimbursement strategy - Assessment of diagnostic assays for analysis for HPV in urine Phase II funding will be requested to further validate the HPV assays for detection of HPV DNA in first void urine and set-up full scale production and exploitation strategy in the EU28 and at global level.

Keywords: cervical cancer screening,hpv test
Sympathetic and immune mechanisms underlying obesity (SympatimmunObesity)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 2029175.0
EU funding (EUR): 2029175.0
Participants: 1
Project status: SIGNED

The era of molecular genetics has enabled the mechanistic dissection of brain circuits as well as the immune system in spectacular ways. However, the molecular and cellular organization of the sympathetic nervous system (SNS), which innervates all known organs, is essentially unexplored. In an attempt to push this frontier, we have recently uncovered a direct physical functional connection between the SNS and the adipose tissue. Further, we found this neuro-adipose junction to drive lipolysis and fat mass reduction (1). In this proposal we aim to define the molecular mechanisms that link SNS neurons, the immune system and the adipose tissue. A major entry point is our recent discovery of a novel population of Sympathetic Associated Macrophages (SAMs) that suppress the output of SNS. We propose to unravel their contribution to obesity in rodents (Aim 1) and in humans (Aim 2). Another major objective of this proposal is to establish a functional and molecular neuronanatomical map of the SNS, which defines subpopulations of neurons that specifically innervate fat (Aim 3). To achieve this, we will build molecular genetics tools for rapid non-invasive optocoustic visualization and functional probing of SNS circuits. A molecular and realistic atlas of the SNS will allow us to systematically access the functional anatomy of one of the most elusive tissues of the mammalian body and will form a blueprint upon which our neuroimmune mechanistic studies can be build. Our identification of the fundamental biological mechanisms that govern the neuro-adipose junction will set the stage for a new anti-obesity therapy that would circumvent the challenge of drug delivery to the brain, i.e. by targeting an excitatory drug directly to SAMs or sympathetic inputs in adipose tissue.

Keywords: obesity,optoacoustics,macrophages,chemogenetics,optogenetics,mouse models,neurocircuits
A rapid, non-invasive, cost-effective, analytical device for bacterial or viral infection diagnosis through ultra-high sensitivity breath analysis. (BreathSpec)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Germany,Ireland,United Kingdom,United Kingdom
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2016-1, 2016)
Start date: 2017-05-01
End date: 2019-07-31
Duration (months): 27.0
Total project cost (EUR): 3323172.5
EU funding (EUR): 2367647.5
Participants: 5
Project status: CLOSED

The world faces a growing epidemic of antimicrobial resistance (AMR); however, only two new classes of antibiotics have been brought to the market in the last 30 years. The discovery and development of new antibiotics is essential to maintain medical advances but poses significant scientific, clinical, and financial challenges, particularly for antibiotics active against Gram-negative bacteria (such as E. coli). Such bacteria have effective barriers against drugs, making treatment difficult, resistance likely and development costs and risks high. In addition, any new antibiotics brought to the market would likely be used cautiously to delay the development of resistance, adding an additional financial challenge in recouping the development costs. The O’Neill Report on AMR identifies diagnostics as critical to the battle against antibiotic resistance. This innovation action, BreathSpec, proposes a viable solution to the global problem of AMR through the final developmental stages of an existing diagnostic device, which will allow a rapid, binary decision to be made on the need for antibiotic treatment, and which with suitable optimisation will allow further differentiation and stratification to take place. The Innovation Action includes technical developments to optimise its function, data acquisition for the development of the decision making analytical function and clinical validation. It addresses these issues by producing reliable identification and quantification of key signature volatiles present in exhaled breath. It provides a non-invasive method for monitoring the volatile organic compounds present in an individual’s exhaled breath (and subsequently the blood) and has long been recognised as having significant utility as a clinical test that can be used for early disease detection and monitoring, and potentially to diagnose specific bacterial infections for better, more targeted use of existing antibiotics.

Keywords: breath analysis,breath,bacteria,viral,antibiotics,antimicrobial resistance,diagnostics
Identification of a novel function of lysosomes in mitosis for cancer therapy (M-Lysosomes)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Controlling cell cycle, process by which cells progress and divide, is at the heart of cancer research therapies. Tumor cells signature often lays in high proliferation rate, alterations of multiple intracellular signaling networks and hijacking of programmed-cell death pathways. Implication of autophagy and lysosomal biology in cancer is still controversial. Lysosomes are catabolic vesicles involved in the degradation of biological material and need to be tightly regulated. Lysosomes may influence cancer formation and progression by regulating many complex processes of cell biology, such as cell signaling, cell death, nutrient sensing and cell metabolism. Lysosome function depends on lysosome acidification capacity modulated by proton pump v-ATPase activity and on its intracellular localization driven by motor proteins, mainly by motor protein kinesin KIF5B. We recently discover an innovative mechanism involving lysosomes impairment to induce mitotic error that could potentially lead tumor cells to cell death.

Keywords: lysosomes,autophagy,lysosomotropic drugs,cancer therapy,mitotic error,cell death
Coming-of-age of Process Research: Connecting Theory with Measurement and Modelling (OPTIMAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Recent innovations in measurement such as ambulatory assessments and experience sampling, have created the unique opportunity to study psychological processes as they unfold over time in everyday life. Combined with novel statistical models that focus on within-person dynamics, these developments offer a radically new perspective on foundational concepts in psychology. In clinical psychology for instance, these innovations are used to study mental disorders as networks of symptoms that trigger each other over time, and this is leading to valuable new insights on the emergence and persistence of psychopathology. How to optimally employ these new tools is a major methodological challenge, however: Researchers must determine whether to use self-reports or physiological measures, what the frequency and duration of the measures should be, and which model fits their data and allows to test their theory. The costs of choosing inapt measurement and modelling methods can be severe and include: invalid results, erroneous conclusions, poor theory building, wasting resources, diminished trust in psychological science, and outcomes that are less useful or even harmful for individuals and society. The aim of OPTIMAL is to resolve this challenge by developing an overarching methodological framework of process research that allows psychological researchers to connect theory, measurement and modelling. To achieve this, I will: a) strengthen the pairwise links between theory, measurement and modelling; b) conduct literature inventories in five substantive areas to elicit information on how to measure and model particular processes; and c) develop a taxonomy of models and an interactive website that researchers can use to guide them to optimal models. The generic nature of this methodological framework guarantees that it will be applicable in virtually all substantive fields within psychology that focus on processes, thus impacting psychological science in its full breadth.

Keywords: intensive longitudinal data,dynamic modelling,simulation research,longitudinal research,methodology,psychometrics