Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
An Investigation into the Sociolinguistic Prehistory of Konkani (INSPIK)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 217965.12
EU funding (EUR): 217965.12
Participants: 1
Project status: SIGNED

INSPIK aims to investigate the sociolinguistic prehistory of a language called Konkani, which is spoken in scattered pockets across four states (Maharashtra, Goa, Karnataka, Kerala) on the western coast of India. As a southwestern Indo-Aryan language neighbouring Dravidian languages such as Kannada, Tulu, and Malayalam, Konkani is intriguing from a language-contact perspective. Konkani has, until recently, remained in a diglossic ‘low’ relationship with other local and colonial literary, more powerful languages. In the absence of any written materials in Konkani prior to the 16th century, resources to undertake historically-oriented research on the language have been limited. INSPIK proposes an innovative use of Sanskrit/Kannada/Prakrit inscriptions discovered in today’s Konkani-speaking regions, oral histories of migration recorded in Sanskrit Puranic texts, modern dialectological documentations of Konkani and other neighbouring languages, and comparative analysis of contemporary linguistic data to reconstruct a sociolinguistic prehistory of Konkani. Recent research has revealed that the Konkani language structure shows robust traces of prehistoric long-term, stable Dravidian and Indo-Aryan language contact. INSPIK will develop the idea further by examining previous language documentations complemented with new data collected for the project. Drawing on these linguistic data, and the insights gathered through inscriptions and ancient literary texts, INSPIK will then critically apply the sociolinguistic typological framework to identify the possible prehistoric sociolinguistic settings during the formation period of Konkani. At the end of the project, INSPIK will introduce an innovative methodology for undertaking historical research on languages with limited written materials, apply the sociolinguistic typology framework to a lesser-known language and test its limitations, and contribute data on Konkani to the Kiel South Asian Typological Database.

Keywords: language contact,india,sociolinguistics,typology,dialectology,indo aryan,dravidian,historical dialectology,konkani,marathi,kannada
Sex differences in the persistence of ADHD in relation to childhood adversity and stress exposure (STRESSADHD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,Iceland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 232916.16
EU funding (EUR): 232916.16
Participants: 2
Project status: SIGNED

STRESSADHD aims to enhance understanding of sex differences in the persistence of Attention Deficit Hyperactivity Disorder (ADHD) into adulthood, particularly in relation to adverse childhood events (ACEs) and stress exposure. ADHD is a common childhood-onset neurodevelopmental disorder. Research has predominantly focused on boys with ADHD while girls with ADHD are often underdiagnosed and undertreated, potentially leading to adverse consequences later in life. There is still limited understanding of why ADHD sometimes remits yet in the majority of cases persists into adulthood. This holds especially for females. STRESSADHD will address this gap by investigating the extent to which persistence in females, including the onset and course of comorbid conditions, can be explained by ACEs and high stress exposure. STRESSADHD will use very large population-based cohort studies linked with national registries and genomic data, a combination uniquely suited for this research. Improved understanding of differences between males and females in relation to ACEs, stress exposure, persistence and comorbid conditions in ADHD will have important clinical implications. STRESSADHD will highlight the importance of sex differences in ADHD and raise awareness about its substantial burden. Sharing our knowledge with health care professionals, individuals with ADHD, and the general public STRESSADHD will improve identification, diagnosis and treatment in males and females.

Keywords: adhd,sex differences,adverse childhood events,stress exposure,lifespan,national registries,cohort study,polygenic risk score
Near-field Communications with XL-MIMO: Cost-Effective Designs (NFComCED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-20
End date: 2027-11-19
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

Extremely large-scale multiple-input multiple-output (XL-MIMO) has been recognized as a crucial enabling technology for the sixth generation (6G) networks to realize extremely high throughput and high-resolution localization. XL-MIMO will bring new features of near-field communication which requires new algorithms and transmission scheme design. Meanwhile, given the extra-large number of antennas on XL-MIMO, the cost (operation overhead, hardware cost, power consumption, algorithm complexity) could be unacceptable in practice. Thus, it is key to realise the promising gains of XL-MIMO at an affordable cost, which however has not been comprehensively studied. This proposal aims to propose a cost-effective framework for implementing XL-MIMO in near fields and gain an in-depth understanding of the working mechanisms behind it. The first objective is to implement cost-effective XL-MIMO in the current commercialized sub-6 GHz band (for macro-cell and uniform coverage), by exploiting statistical channel state information (CSI) for beamforming design and exploiting sparse array architectures to reduce the number of antennas while maintaining the array size. The second objective is to propose cost-effective design for XL-MIMO in the mmWave band with rich spectrum resources (for micro-cell hotspots and indoor communication) by using two-timescale design for hybrid precoding and employing energy-saving metamaterial antennas. The third objective is to solve the blockage issue for XL-MIMO and realise ubiquitous coverage in a cost-effective way, by leveraging the nearly passive reconfigurable intelligent surface. Besides, this proposal plans to conduct prototype measurements to validate the effectiveness of the proposed algorithms and architectures. This project is expected to significantly enhance the fellow’s career prospects, enabling him to develop new research skills, establish professional networks, learn leadership skills, and grow into an influential expert in academia.

Keywords: near field communications,extremely large scale multiple input multiple output xl mimo,reconfigurable intelligent surface ris,sub 6ghz mmwave communications,statistical csi,beamforming design
Biocultural roots of diversity and inequality in Mexico: 500 years of mestizo stories (AdMEXture)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Spain
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2495911.0
EU funding (EUR): 2495911.0
Participants: 1
Project status: SIGNED

Transatlantic contact during the 1400’s ignited a series of socio-economic, political, demographic and biocultural changes that irreversibly transformed the course of history in the Americas with repercussions across the world. But one of the most influential encounters occurred in 1519 between the Mexica empire and the Spanish and African troops of Hernán Cortes in the basin of today´s Mexico. The transformational consequences were unparalleled at the time, but equally consequential is the way that the so-called conquest of Mexico has been portrayed over the last five centuries, influencing how the populations involved in this iconic event have perceived themselves and their societies overtime. Of particular significance is the process of mestizaje (admixture) and its conceptualisation. Admixture is a common biological phenomenon in human history, but the perception of mestizaje in the context of this event is far more complex than a mere biological procedure, it is a complex biocultural process shaped by fluctuating social, cultural, biological and historic circumstantial events. The recently commemorated quincentennial anniversary of this event and the debates surrounding it highlighted that the underlying biocultural forces driving mestizaje leading to the present-day population diversity of Mexico remain contested. AdMEXture will explore historical biological effects of social inequalities with particular emphasis on sex bias and differential reproduction patterns, in the survival and distribution of diversity. By generating serial multisource osteobiographies based on the latest experimental and analytical bioarcheological techniques, AdMEXture will deliver crucial data to be incorporated in state-of-the-art historic debates. These individual microhistories will provide examples of real participants in this process, contributing to a more inclusive and representative history.

Keywords: mestizaje bioarchaeology admixture osteobiographies inequality prehispanic mexico
Origin and Development of the B cell response during Immunoregulatory Helminth Infections (B-SELECT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1499935.0
EU funding (EUR): 1499935.0
Participants: 1
Project status: SIGNED

One-fourth of the global population is currently infected with helminths, which modulate host immunity against not only their own antigens but also non-cognate antigens, including vaccines. While antigen-specific antibodies and memory B cells are essential for protection against infectious diseases, how the B cell response quality is influenced by helminths remains largely unknown. With my core expertise in studying responses to parasites at the level of single B cells and monoclonal antibodies, I aim to delineate the onset and quality of B cell responses formed during immunoregulatory helminth infections, impacting the development of effective vaccines. The B cell response quality relies on recruiting antigen-specific naïve cells and selecting high-affinity B cells to form antibody-secreting cells and memory B cells. However, how these well-established mechanisms are impaired during B cell immunity modulated by helminths remains unknown. Therefore, the goal of this ERC proposal is to elucidate the molecular principles governing the formation and selection of antigen-specific B cells during helminth-induced immunoregulation and to identify strategies to mitigate modulation. To achieve this, I will investigate the origin and development of de novo helminth antigen-specific B cell responses in the unique controlled helminth infections in naïve individuals and vaccine-specific B cell responses in residents of helminth-endemic areas. Access to clinical samples, advanced human tonsil organoids and transgenic mouse models, combined with my state-of-the-art expertise in studying antigen-specific B cells, uniquely positions me to uncover paradigm-shifting molecular principles that guide B cell responses during helminth infections. Ultimately, I aim to provide the first proof of concept to mitigate modulatory effects and rescue B cell response quality, paving the way to address global health challenges by inducing protective vaccine response in helminth-infected individuals.

Keywords: helminth infections,antibody repertoire,single b cell studies,vaccine responses
Biomimetic Sensorized Barriers-on-a-Chip: Unveiling a new Generation of Market-Ready Investigation Tools (BiSCUIT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-07-01
End date: 2025-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The lack of reliable in vitro pre-clinical models represents a critical aspect unanimously recognized by the scientific community as detrimental in the pathway of bringing new medications from the laboratory to the bedside: addressing this issue would provide immense benefits to drug discovery and development processes, by ethically limiting animal testing and drastically reducing costly failures in clinical trials. To date, most in vitro models fail at recapitulating the physiological microenvironment, and this often results in misleading data withdrawal. Starting from my prototype of real scale, dynamic and biomimetic blood-brain barrier model, in this project I aim at the validation of my system, after an upgrade step consisting in embedding sensing features in the platform, thus allowing a real-time evaluation of barrier formation and integrity maintenance. Characterized by microcapillary size/fenestrations and fluid flows similar to the in vivo physiological barrier, my tool will represent a drastic innovation over other well-established models in the literature and available on the market, allowing a reliable reproduction of the physiological environment and an accurate estimation of the amount of drug and/or nanomaterial concentration delivered through the barrier. Validation will be performed in relevant conditions, by implementing stroke and brain cancer models. All artificial components will be fabricated through two-photon polymerization (2pp), a disruptive mesoscale lithography technique that allows the fast fabrication of low-cost structures with resolution up to the nanometer scale, as well as great levels of scaffold reproducibility/accuracy. The proposed platform can be easily adopted in research laboratories and pharmaceutical industries as an advanced pre-clinical model, the primary biomedical applications of which consist in reliable screenings of drugs against pathologies of the central nervous system.
Spatial Quantum Optical Annealer for Spin Hamiltonians (HEISINGBERG)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Cyprus,Italy,Greece,United Kingdom,Spain
Call: EIC Pathfinder Challenge: Alternative approaches to Quantum Information Processing, Communication, and Sensing (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-11-01
End date: 2027-10-31
Duration (months): 48.0
Total project cost (EUR): 3260250.0
EU funding (EUR): 3260250.0
Participants: 6
Project status: SIGNED

Optical simulators rank among the most promising candidates to power future technological breakthroughs in terms of speed, scalability, power-consumption and quantum advantage, serving a wide range of useful optimization problems. However, the operation of such simulators remains currently limited by noise, the extent of algorithmic problems they can embed and to the classical regime where they compete with supercomputers. HEISINGBERG aims to bring our state-of-the-art spatial photonic spin simulator (an iterated cycle of all-optical processing through a spatial light modulator that couples 10,000 spins) into the quantum regime by upgrading its coherent drive to squeezed light, making it fully programmable through vector-matrix multiplication schemes, use of holography, ancillary spins & effective magnetic fields, and designing dedicated custom-tailored and purpose-built algorithms. The reduced fluctuations in one quadrature of the fields will allow us to scale up and optimize the performances of the existing machine to bring it beyond the capabilities of both classical supercomputers and competing spin-simulators. HEISINGBERG devices will operate 100,000 spins at room temperature and process new quantum annealing algorithms on an improved XY architecture. Besides, the nonclassical resources of squeezed states when modulated, admixed and phase-controlled through beam splitters, such as entanglement or superpositions of multiphoton states will be prospected to harness a quantum advantage and boost our machine into its quantum simulation regime. This development will stimulate the quantum information processing community by concretely articulating problems of algorithmic complexity and clarify the nature of the quantum advantage available in annealers and simulators. These advances will allow us to demonstrate, on a cloud platform, annealing and adiabatic algorithms that can efficiently solve NP-hard problems.

Keywords: quantum simulator spatial photonic spin simulator annealing and adiabatic algorithms cloud platform
Bismuth Redox Catalysis for C–C Coupling Reactions (Cross-Bit)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Formation of C‒C bonds through transition metal-catalyzed cross-coupling represents the cornerstone strategy to build chemical complexity in a myriad of contexts, spanning from academic laboratories to industrial settings. These remarkable reactions generally proceed through three elementary steps —oxidative addition, transmetallation and reductive elimination— which couple two organic fragments together using transition-metal complexes as redox-active catalysts. Very recently, bismuth —a main-group element— has been found to take part in this type of redox events, resulting in the formation of different C–heteroatom bonds, or in H-transfer processes. However, the use of bismuth redox catalysis to forge the highly coveted and synthetically relevant C–C bond remains elusive. In this project, we aim to harness this novel redox behavior of bismuth complexes to unlock the unprecedented bismuth-catalyzed C–C cross-coupling full catalytic cycle between organic electrophiles and organometallic nucleophiles. For this, we propose the design of a low-valent bismuth(I/III) redox platform, which would cycle through the three key steps of a classical transition metal-mediated coupling. This will involve the study and optimization of challenging processes (such as an unprecedented C–C reductive elimination at a bismuth(III) center), which will be approached through a combination of careful ligand design, experimental/theoretical mechanistic analysis, and combinatorial screenings. Besides the conceptual breakthrough derived from such discovery, this idea will be used to implement bismuth-catalyzed cross-coupling reactions as competent, cheaper, and less toxic alternatives to traditional methods based on transition-metal catalysis. Furthermore, the unique properties of bismuth as a main-group redox catalyst could potentially combine advantages of both early and late transition metals, resulting in the development of more versatile catalytic systems.

Keywords: main group metal catalysis,bismuth catalysis,cross coupling reactions,synthetic methodology development
Emotional COupling in interpersonal SYNChronization (ECoSync)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway,Canada
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 275523.36
EU funding (EUR): 275523.36
Participants: 2
Project status: SIGNED

The proposed action titled “ECoSync” aims to incorporate computational modelling as a pivotal framework for elucidating the intricate dynamics of social bonding. This new framework is crucial for the European Work Programme in the current global crises. The action perfectly aligns with the Programme's vision of addressing pressing societal challenges for the well-being and stability of European communities. Recognizing the profound impact of emotions on human well-being, this research endeavors to uncover the underlying mechanisms that govern the emergence of social bonding. The action includes training in computational modelling and fundamental research in musical performance. It highlights interpersonal synchronization as a method for cultivating strong interpersonal connections. Understanding the interplay between emotions and interpersonal synchronization in musical interaction opens up new avenues for exploration, supporting resilience and recovery in the context of global adversity through social bonding. To quantify the processes underlying the formation of social bonds, we will execute a sequence of three work packages (i.e., WP2-WP4). These work packages will synergistically integrate cutting-edge methodologies from nonlinear dynamical systems, social and affective neurosciences, and music psychology. WP2 will focus on the computational mapping of emotional effects on interpersonal coupling. In WP3, we will validate and refine the model through empirical dyadic musical interaction, leveraging advanced motion capture and physiological techniques. In WP4, we will investigate how emotions influence group synchronization and its subsequent impact on social bonding. Finally, the action’s international mobility and training in research will broaden the applicant's academic portfolio and develop extensive experience as well as professional connections, furthering the advancement of the applicant's career as an independent researcher.

Keywords: interpersonal synchronization,delay coupled modelling,social bonding