Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Clonal hematopoiesis in cancer (CHIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-09-01
End date: 2031-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Clonal hematopoiesis (CH) is the expansion of somatically mutated hematopoietic stem cells. Clonal hematopoiesis of indeterminate potential (CHIP) occurs when CH is driven by mutations in myeloid driver genes in individuals without hematologic disorders. CHIP increases the risk of hematological malignancies and chronic inflammatory diseases. CHIP is also associated with a higher incidence of non-hematological malignancies, such as lung cancer. These associations underline the importance of CHIP in the development of both malignant and non-malignant diseases. Patients with cancer have higher prevalence of CHIP compared to the general population and are at risk of developing therapy-related myeloid neoplasms (t-MN). As the prognosis of t-MN patients is poor, identifying and managing cancer patients with CHIP at risk of developing t-MN is critical. Moreover, patients with solid tumors and CHIP have an excess mortality not fully explained by increased rates of hematologic or cardiovascular diseases. Thus, a knowledge gap remains in understanding the role of CHIP in cancer, both in solid tumor progression and as a precursor to high-risk t-MN. I propose to address key challenges in four interconnected areas of (1) early detection of CHIP, (2) systemic role of CHIP at the solid tumor-immune interface, (3) interception of CHIP evolution, and (4) precision diagnostics at progression to t-MN, using a multidisciplinary approach at the intersection of computational genomics, artificial intelligence, myeloid cell tumor biology, and precision oncology. I will develop tools for the early detection of CHIP during routine clinical care, elucidate the role of CH in tumor evolution, identify mediators of CHIP evolution towards t-MN, and define a novel molecular t-MN classification. This project has the potential to transform our understanding and management of CHIP in cancer.

Keywords: clonal hematopoiesis of indeterminate potential,early detection,interception,tumor microenvironment,lung cancer,therapy related myeloid neoplasms
Colloidal control of multi-phase flow in geological porous media (COCONUT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: France,United States
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1998744.0
EU funding (EUR): 1998744.0
Participants: 4
Project status: SIGNED

The COCONUT project aims at developing predictive capabilities to understand how colloids (nanometals, fine particles, bacteria, viruses, asphaltenes..) control immiscible two-phase flow in complex geological formations. Colloids (including nanoparticles) have an incredible potential to remobilize non-aqueous phases trapped by capillary forces in soils and the subsurface, and then to remediate contaminated groundwater or to enhance oil recovery. Their use in daily engineering, however, is still underexploited because the lack of knowledge regarding their transport mechanisms is an obstacle to precise control of two-phase flow. Importantly, the presence of colloidal particles flowing in the subsurface challenges the standard modeling viewpoint of flow and transport based on Darcy's law. We posit that the precise control of colloids on the motion of two-phase flow can only be achieved by developing a deep knowledge of the coupled hydro-electro-chemical processes at the pore-scale. The COCONUT project uses a combined modelling-experimental strategy focusing on the pore-scale mechanisms and on the upscaling to the continuum-scale. The project is multi-disciplinary and uses computational and experimental sciences, fluid dynamics, electrochemistry, and mathematics. The project will require the development of hydro-electro-chemical computational models at different scales of interest (WP1). We will use high-resolution simulations to interrogate emergent physico-chemical processes and characterize the surface attractive and repulsive forces at the nanoscale (WP2). Then, we will decipher the mechanisms leading to the displacement of fluids trapped in an unsaturated porous medium in the presence of colloids using pore-scale modelling and microfluidic experiments (WP3). Finally, we will demonstrate and optimize the two-phase flow colloidal control in geological systems at the column-scale (WP4).

Keywords: porous media pore scale modeling microfluidics colloids hydro electro chemical coupling
BIOremediation systems exploiting SYnergieS for improved removal of Mixed pOllutants (BIOSYSMO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Spain,Slovenia,France,Belgium,Germany,United Kingdom,Portugal,Greece
Call: Environmental services: improved bioremediation and revitalization strategies for soil, sediments and water (HORIZON-CL6-2021-ZEROPOLLUTION-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 4873331.0
EU funding (EUR): 4873331.0
Participants: 17
Project status: SIGNED

BIOSYSMO is a 48-month action that will develop a computationally-assisted framework for designing and optimizing synergistic biosystems combining the required pathways and traits to achieve the most efficient degradation and sequestration of pollutant mixtures. These biosystems will comprise combinations of bacteria, fungi and plants containing the natural or engineered pathways required for pollutants degradation and identified based on a computationally-assisted analysis. BIOSYSMO will take advantage of the high natural microbial diversity by screening samples from polluted sites and locations affected by diffuse pollution to identify natural microorganisms already present and able to metabolize the target pollutants. The search will be expanded to microorganisms previously identified and characterized by applying data mining tools to genomic and metagenomic data available in public repositories. The construction and optimization of synergistic biosystems will combine approaches based on 1) enhancing plant-microbe (bacteria, fungi) interactions to achieving combinations with improved pollutant uptake and/or degradation; 2) engineering bacteria, for improved degradation and bioaugmentation, and plants (poplar tree), for improved microbial colonization and pollutant uptake; 3) constructing artificial micro-structured consortia into aggregates and biofilms, containing all the required pathways for pollutant removal; and 4) applying bioelectrochemical systems (BES) as stand-alone or in hybrid systems. The different key players will be identified and combined to formulate innovative biosystems with the assistance of genome-scale metabolic (GEM) models for elucidating and simulating the key metabolic pathways. The constructed biosystems will be applied in conventional (phytoremediation, biopile, bioaugmentation) and innovative (BES, hybrid BES-phytoremediation) bioremediation approaches optimized for the treatment of mixtures of pollutants in soil, sediments and water.

Keywords: bioremediation biodegradation phytoremediation bioaugmentation bioelectrochemical systems metabolic pathways genome scale model plant microbe symbiosis microbial community
Multi-scale incidence geometry (MUSING)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Finland
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-08-01
End date: 2028-07-31
Duration (months): 60.0
Total project cost (EUR): 1362842.5
EU funding (EUR): 1362842.5
Participants: 1
Project status: SIGNED

The ERC CoG project MUSING aims to make progress in several old problems in geometric measure theory (GMT), including Vitushkin's conjecture from the 60s, and the Furstenberg set conjecture proposed by Wolff in the 90s. Both problems are related to sharpening and generalising some cornerstone results in GMT, such as the projection theorems of Besicovitch and Marstrand. Recent work on these questions combines techniques from GMT, additive combinatorics, harmonic analysis, and incidence geometry. Vitushkin's conjecture is motivated by the Painlevé problem on finding a geometric characterisation for the removable singularities of bounded analytic functions. The Furstenberg conjecture has direct links to other key open problems in continuum incidence geometry, such as Falconer's distance set problem, and the Erdös-Szemerédi sum-product problem. MUSING will tackle its problems with techniques from multi-scale analysis, and via the special case of Ahlfors-regular sets. These sets are uniform at different scales and locations, so they are particularly amenable to multi-scale methods. On the other hand, progress in the Ahlfors-regular special cases can often be extended to more general sets via mechanisms such as the corona decompositions of David and Semmes, and the scale block decomposition technique, devised by Keleti and Shmerkin in their work on Falconer's distance set problem. Apart from being a stepping stone on the way to general sets, Ahlfors-regular sets also have great independent interest. Evidence is accumulating that incidence geometric problems may admit far stronger solutions for Ahlfors-regular sets than for general sets. Conclusive results of this type already exist for classes of dynamically generated sets, notably self-similar sets, due to the works of Hochman, Shmerkin, Wu, and others. To what extent can these results be extended to Ahlfors-regular sets, which share the spatial uniformity of self-similar sets, but lack an underlying dynamical system?

Keywords: vitushkin s conjecture,furstenberg sets,projections,visibility problem,distance set problem,hausdorff dimension,incidence geometry,sum product theory,uniform rectifiability
Scalable and Modular robotic tools for pipeline inspection and repair (TUBERS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: France,Greece,Netherlands,United Kingdom
Call: AI, Data and Robotics for the Green Deal (AI, Data and Robotics Partnership) (IA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 3140832.49
EU funding (EUR): 2400141.0
Participants: 15
Project status: SIGNED

The European water network distribution is plagued by leaks that cause a staggering 20% of drinking water to go wasted. This is an environmental disaster given that water and sanitation sector is currently estimated to contribute up to 5% of global GHG emissions. Water utilities are struggling with this problem however the deadalic nature of water networks make manual inspections and repairs completely non-viable. Technology-based solutions have significant limitations in terms of measurement accuracy and leak localisation. Most importantly they do not encompass repair. TUBERS sets forth a new paradigm by creating the world’s first combination robotic platforms allowing for 24/7 inspection and targeted in-situ repairs, greatly reducing the costs of regular inspection and maintenance. The system will comprise: (a) A snake-like resident robot which can operate over long distances and negotiate pipeline-junctions to navigate large parts of the water network, (2) A modular soft-robotic platform capable of moving using an “inchworm” movement technique, for inspections and repairs of pipe segments featuring a novel repair deployment mechanism (3) A High-accuracy inspection system that can detect leaks and, most importantly, measure corrosion based on coded excitation, an advanced technique that greatly improves Signal-to-Noise ratio, (4) A Decision Support System powered by Explainable Machine Learning algorithms incorporating a Multi-Criteria Decision Analysis framework for holistic planning of inspection and maintenance. The TUBERS solution will be validated in real water network pipelines operated by 3 of the most prominent water utility companies in the Netherlands. Once it reaches the market, our solution is poised to revolutionise inspection and repair of drinking water networks, providing the operators with powerful tools to eliminate waste, facilitating savings of an estimated 158GWh of energy and reduction of 79.000 tonnes of CO2 emissions within a 5-year period.

Keywords: snake robot,drinking water,inspection and maintenance,pipelines,explainable machine learning,ultrasonic testing,pipeline inspection
Development of Micro-Magnetron for Terahertz Imaging Applications (Micro-magnetron)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2025-02-28
Duration (months): 28.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: CLOSED

Famous scientist Freeman Dyson states that most of the scientific developments are tools and instruments driven. For instance, X-rays, as a scientific tool was discovered by Roentgen using Lenard's vacuum tube. Apart from the significant scientific breakthrough and discoveries, the technological advancement of tools is needed to serve the growing demands in communication, healthcare, security and manufacturing industries. Medical imaging applications from cancerous cells diagnostic to teeth caries, space applications from the universe exploration to upper atmosphere studies, homeland security applications to identify persons with concealed arms, and industrial applications such as non-destructive testing can be made possible with non-ionising, high bandwidth THz frequencies. Despite these advantages, A THZ gap exists between electronics and photonics. Compact electron devices are needed to exploit these potential advantages. With the collisionless propagation nature of an electron beam, the micro vacuum electron devices generate higher power per unit volume than solid-state devices and Lasers. From the victory of World War II to present daily services in our kitchen, magnetron tube has given unbeatable performance at many scientific and industrial fronts. With these motivations, we put this veteran magnetron tube on THz fronts in the current proposal. The THz micro-magnetron is proposed to serve medical imaging and RADAR applications for homeland security, earthquakes evacuation, material investigation. The EM wave power generation with a high degree of compactness will be turned into an innovative solution as listed: 1. With a non-ionising nature, the THz micro-magnetron based system is an economical alternative for medical imaging, including various cancer diagnostic 2. A portable standoff device for the detection of concealed arms at crowded places. 3. Highly suitable for restricted payload environments such as space-borne RADAR and UAV-enabled 3D imaging RADAR.

Keywords: magnetron,microfabrication,medical imaging,radar,terahertz,vacuum electronics
The actuation of sound change (SoundAct)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-02-01
End date: 2028-01-31
Duration (months): 60.0
Total project cost (EUR): 2468550.0
EU funding (EUR): 2468550.0
Participants: 1
Project status: SIGNED

In William Shakespeare's times, 'knee' and 'knot' were pronounced with a /k/, just like German does today. But why did English and not German drop the /k/? This question is part of the actuation of sound change, recognised as one of the greatest challenges in linguistics, and which is about explaining why sound change happens, and why languages can follow such different paths of sound change. The actuation puzzle remains unsolved principally because the beginning of sound change is so gradual that it is undetectable even with modern instrumentation. Yet a breakthrough is essential for explaining why languages split and diversify. The project remedies this deficiency by determining how the cognitive mechanisms that control human speech processing, the social factors that bind individuals together, and the phonetic properties that shape a community's dialect, can, in combination, cause the sounds of the world’s languages to become unstable and change. The methodological innovation is to recast the elusive actuation puzzle as an empirically tractable transformation of an input (A) into an output (B). Here A and B are two closely related, geographically proximal, living dialects whose sound patterns differ in whether one or more common sound changes have taken place. The actuation puzzle is then solved with experiments in human speech imitation and computational modelling in order to estimate which combination of cognitive, social, and phonetic factors transforms A into B. Generalisation is achieved by selecting dialect pairs from Bantu, Indo-European, and Japanese languages that differ markedly in their sound patterns and sociocultural background. The wider scientific impact lies in the commonality with many disciplines including ecology, economics, and geoscience in understanding complex systems (here: language) in which interactions between sub-components (here: communicating speakers) cause transitions (here: sound change) that are unevenly distributed in time.

Keywords: human speech processing speech sciences phonetics sound change agent based modelling
(Re)Constructing the Archaeology of Mobile Pastoralism: bringing the site level into long-term pastoral narratives (CAMP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1968851.5
EU funding (EUR): 1968851.0
Participants: 2
Project status: SIGNED

CAMP investigates long-term pastoral dynamics in drylands, by developing an innovative and reliable methodology to study archaeological pastoral sites. Pastoralism has been recently endorsed by the FAO as a successful strategy to achieve food security by efficiently exploiting the inherent variability in natural resources. Modern pastoral systems represent the legacy of animal domestication processes that started before the beginning of the Holocene. However, our understanding of ancient pastoralism is hampered by the lack of a proper methodology that can overcome the ephemeral evidence that characterize pastoral sites. CAMP will pave the way, through methodological innovation, to a more thorough investigation of past adaptation to dryland environments. Highly controlled data on the anthropic markers for pastoral activities (chemical multi-element by portable X-Ray Fluorescence, phytoliths, organic residues and isotopes) will be collected in pastoral ethnographic settlements and analyzed to create models that will then be used to interpret the archaeological evidence. CAMP will advance research in: (a) methods and theory in the archaeology of pastoralism; (b) anthropic activity markers and the use of pXRF in archaeology; and (c) adaptive strategies in drylands. This project is a unique opportunity to strengthen the study of pastoralism by providing a widely applicable methodology that can augment our knowledge on past human adaptation to drylands and inform the design of sustainable and historically-grounded development strategies for pastoral futures. CAMP methodology will be potentially exportable to other archaeological sites, independently of their chronology, cultural or geographic context, representing an invaluable advance to archaeological methods at large.

Keywords: pastoralism geo ethnoarchaeology drylands anthropogenic deposits multi element analysis pxrf geostatistics
DDG-MRI for Cancer Detection – A Novel Medical Imaging Approach that Correlates to FDG-PET Without Ionising Radiation - New Non-Animal Models for the Project (DDG-MRI)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Israel,Portugal
Call: Hop-on facility (HORIZON-WIDERA-2025-03, 2025)
Duration (months): 18.0
Total project cost (EUR): 599952.5
EU funding (EUR): 599952.5
Participants: 2
Project status: CLOSED

This Hop-On proposal aims to provide non-animal models for the DDG-MRI project. These models will mimic the 3D structure of the tumors that should be detected and the vasculature perfusing them. This will provide tools to predict the utility of the deuterated deoxyglucose analogs being developed in this project for tumor detection and characterization, as well as for monitoring treatment response.

Keywords: deuterated deoxyglucose,non animal models of cancer tumors