Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A bone marrow mimicry bioreactor for cost effective production of hematopoietic stem cells (MarrowMimi)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: SIGNED

Hematopoietic stem/progenitor cell (HSPC) therapies have the potential to treat over 70 diseases including blood cancers and leukemia and are one of only 22 advanced therapy medicinal products currently approved by the European Medicines Agency. However, the number of HSPCs derived from a single blood donation can be insufficient for modern therapies, which typically require a minimum of 10^7 cells. To service adequate treatment regimes, HSPCs must be expanded in the laboratory at great financial expense, resulting in exorbitant treatment costs of up to €315,000. New methods of ex vivo HSPC expansion are therefore required to reduce production costs and ensure therapy affordability. The industry standard for HSPC expansion utilises liquid suspension bioreactors, where cells are diluted in litres of culture media to a final concentration of only 10^3-5 cells/mL. This liquid media, containing large amounts of expensive nutrients, provides high cell expansion but results in high production costs. Liquid suspension bioreactors vary significantly from how humans grow HSPCs within high-cell-density tissue (10^8-11 cells/mL), which require only a fraction of the nutrient quantities per-cell. The bone marrow is the human body’s natural HSPC bioreactor and provides a defined microenvironment for optimal cell production. I aim to artificially replicate these niche conditions by creating a marrow mimicry bioreactor (MarrowMimi) to maximise ex vivo HSPC expansion by (1) formulating a hydrogel scaffold to mimic the bone marrow extracellular matrix, (2) utilising state-of-the-art 3D printing technologies to create a marrow-like perfusion bioreactor, and (3) optimising reaction conditions to maximise HSPC expansion and minimise nutrient demand. The ability to minimise HSPC expansion-associated costs could ensure lifesaving therapies are more widely available to the community, therefore, MarrowMimi will focus on optimising methods for cost effective ex vivo HSPC production.

Keywords: tissue engineering,biomaterials,stem cell biology,additive manufacturing
In situ analysis of chaperone mediated protein folding and stability (INSITUFOLD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-08-01
End date: 2027-07-31
Duration (months): 60.0
Total project cost (EUR): 2136875.0
EU funding (EUR): 2136875.0
Participants: 1
Project status: SIGNED

Molecular chaperones mediate protein folding and conformational maintenance. Failure of these fundamental cellular functions results in a breakdown of protein homeostasis (proteostasis) and facilitates the manifestation of diseases associated with protein aggregation. Much progress has been made in understanding the mechanisms of individual chaperone systems, such as the Hsp70s and the chaperonins, based on analyses in vitro. How these machineries function in the intact cell is not well understood, however. The goal of this proposal is to observe and characterize the dynamic action of the major chaperone systems and their interplay in intact cells in real time.Using live cell single molecule imaging combined with biochemical analyses, proteomic profiling, and genetic screening, we will address the following questions: i) How does the chaperone machinery assist protein chains during and after translation to achieve folding and assembly? We will develop single particle tracking to monitor the chaperone engagement of nascent chains in situ in mammalian cells. ii) How is the conformational stability of chaperone clients assessed, maintained and triaged in healthy cells and in cells burdened with pathological aggregates? We will track the interactions of metastable proteins with chaperones and proteolytic machinery. iii) What is the efficiency of protein folding across the proteome under normal conditions and in chaperone-deficient cells? Pulse proteolysis/mass spectrometry will be developed to analyze the folding of nascent polypeptides and will be scaled to analyze the entire proteome of different cell types. By depleting specific proteostasis components we will explore the capacity of the chaperone network for compensatory rewiring and identify vulnerable proteins with an obligate chaperone dependence. Overall, this work will employ new technology to advance our understanding of the chaperone system in protein folding and proteome maintenance at the cellular level.

Keywords: protein folding,molecular chaperones
DevelopIng STratEgies by integrating mitigatioN, aDaptation and participation to climate changE Risks (DISTENDER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Spain,Greece,Italy,Portugal,Germany,Netherlands,Poland,Slovenia,Austria,Ukraine,Hungary,France,Lithuania,United Kingdom
Call: Better understanding of the interactions between climate change impacts and risks, mitigation and adaptation options (HORIZON-CL5-2021-D1-01, 2021)
Start date: 2022-06-01
End date: 2025-11-30
Duration (months): 42.0
Total project cost (EUR): 6417722.13
EU funding (EUR): 6417721.0
Participants: 32
Project status: SIGNED

DISTENDER will provide integrated strategies by building a methodological framework that guide the integration of climate change (CC) adaptation and mitigation strategies through participatory approaches in ways that respond to the impacts and risks of climate change (CC), supported by quantitative and qualitative analysis that facilitates the understanding of interactions, synergies and trade-offs. Holistic approaches to mitigation and adaptation must be tailored to the context-specific situation and this requires a flexible and participatory planning process to ensure legitimate and salient action, carried out by all important stakeholders. DISTENDER will develop a set of multi-driver qualitative and quantitative socio-economic-climate scenarios through a facilitated participatory process that integrates bottom-up knowledge and locally-relevant drivers with top-down information from the global European Shared Socioeconomic Pathways (SSPs) and downscaled Representative Concentration Pathways (RCPs) from IPCC. A cross-sectorial and multi-scale impact assessment modelling toolkit will be developed to analyse the complex interactions over multiple sectors, including an economic evaluation framework. The economic impact of the different efforts will be analyse, including damage claim settlement and how do sectoral activity patterns change under various scenarios considering indirect and cascading effects. It is an innovative project combining three key concepts: cross-scale, integration/harmonization and robustness checking. DISTENDER will follow a pragmatic approach applying methodologies and toolkits across a range of European case studies (six core case studies and five followers) that reflect a cross-section of the challenges posed by CC adaptation and mitigation. The knowledge generated by DISTENDER will be offered by a Decision Support System (DSS) which will include guidelines, manuals, easy-to-use tools and experiences from the application of the cases studies.

Keywords: adaptation,mitigation,climate risk,synergies,economic evaluation,robust actions
Geometric algorithms for transport network graphs (GA-TNG)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-03-01
End date: 2027-02-28
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

Graphs have been used to analyse transport networks for hundreds of years. However, graphs are general structures and many graph algorithms are very slow. Specialised algorithms are much more efficient but can only be applied to restricted graph classes. Transport network graphs suffer from a lack of efficient specialised algorithms, since most graph classes are too restrictive and do not accurately represent real-world transport networks. Recent developments have led to geometric graph classes that are tailored to real-world transport networks. One of these geometric graph classes, phi-low-density graphs, captures the property that there are more connections between geographically nearby nodes than geographically distant ones. Unfortunately, the fundamental properties of phi-low-density graphs are not well understood, which has prevented the development of a wide range of specialised algorithms. My objective is to fill the acute need for a simple and versatile graph class that accurately represents real-world transport networks. My research will allow experts to finally harness the power of specialised algorithms on a wide range of important transport network problems. I will achieve my objectives through two sub-objectives: (1) To build fundamental structures for phi-low-density graphs, and (2) To design provably efficient specialised algorithms for phi-low-density graphs. I will be support by my host institution (University of Copenhagen), my host group (Basic Algorithms Research Copenhagen), my primary supervisor (Mikkel Abrahamsen), and my secondary supervisor (Rasmus Pagh).

Keywords: geometric algorithms,graph algorithms
European Training Program to Understand, Diagnose and Treat Autosomal Dominant Retinal Diseases (ProgRet)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium,Netherlands,Germany,Italy,France,Spain,Czechia,Switzerland,United Kingdom,Ireland
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 2737859.66
EU funding (EUR): 2626200.0
Participants: 18
Project status: SIGNED

ProgRET will create a multidisciplinary and intersectoral European training network focusing on the mechanisms, diagnosis and therapy of dominantly inherited retinal diseases (IRD). IRD represent a major cause of blindness, affecting 350,000 people in Europe. IRD have long been considered incurable, however major advances have led to groundbreaking new treatments. Today, the most important challenges in the IRD field relate to an unsolved genetic diagnosis, unknown disease mechanisms and gene therapy development for autosomal dominant IRD (adIRD), representing 25–40% of all IRD cases. We have demonstrated an emerging role for splicing factors, structural variants and non-coding defects in patients with adIRD, and developed novel disease models and gene therapies for adIRD. ProgRET aims to dissect adIRD mechanisms using retinal stem cell and aquatic animal models, to advance adIRD diagnostics using a single-molecule multi-omics framework, and to develop innovative treatments based on RNA therapy and CRISPR-genome editing. These challenges will be tackled by integrating unique expertise and cutting-edge technology within ProgRET, including (multi-)omics, bioinformatics, functional genomics, RNA biology, gene regulation, stem cell technology, retinal organoids, animal models, genome editing and gene therapy. ProgRET will give Doctoral Candidates (DCs) unparalleled training opportunities in outstanding academic and industrial settings through training-by-research via individual research projects, secondments, and network-wide training sessions. All individual training and research activities will provide each DC with the necessary skills in academic and industrial research. ProgRET will make a career in both sectors attractive and improve their career prospects. Finally, our multidisciplinary network offers a unique opportunity to accelerate the understanding, diagnostics and therapeutics for adIRD in Europe, and to translate research findings to healthcare and society.

Keywords: genetic and genomic variation,genome editing,stem cell biology,animal disease models,therapy development,blindness,rare disease
Sustainble alternative to flexible packaging (FlexFoam)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Finland
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-01-01
End date: 2025-09-30
Duration (months): 33.0
Total project cost (EUR): 3562500.0
EU funding (EUR): 2493750.0
Participants: 1
Project status: SIGNED

Paptic Foam is a new material for flexible packaging, combining the sustainability of paper, versatility of plastics and haptics of textiles. Our material is compatible with the production processes of the respective flexible packaging value chain thus can be easily introduced in processing. The unique haptic properties also enable consumers to differentiate the products, improving efficiency of sustainability communication of end-users/brand owners. Paptic already has developed and piloted the foam technology to produce renewable, recyclable and reusable wood-fibre based material that is over 50% more resource efficient compared to paper. Paptic’s patented material technology has vast application opportunities in various flexible packaging market segments like dry and frozen food packaging, electronics, hygienic products, toys, etc. Our technology enables resource efficient manufacturing and higher product performance, enabling position of most sustainable alternative to plastics.

Keywords: materials engineering,production technology,process engineering,resource efficiency,foam technology,flexible packaging,recycling,environment,pollution and climate
Governing the Urban Dimension of European Law (GUD EU Law)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-06-01
End date: 2025-11-30
Duration (months): 30.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: SIGNED

‘GUD EU Law – Governing the Urban Dimension of EU Law’ explores how constitutional principles can enhance integration of urban policies with the European Union (EU) legal order. It critically analyses EU judgements and practices of the EU Urban Agenda to provide a richer understanding of how EU law impacts environmental sustainability and social inequalities in EU cities. Based on this, it will advance proposals for a refashioned interpretation of constitutional principles of subsidiarity and proportionality, constructing an empirically-based understanding of when and how EU institutions should regulate policies with implications on urban spaces. GUD EU Law innovatively combines doctrinal legal research with critical geography’s contextual case analysis and semi-structured interviews to experts. Conceptually, it analyses trends the effects of EU law on urban spaces reveal about limits and possibilities of the EU to solve urgent societal issues, advancing debates on constitutionalism, policy and sociology. To achieve these objectives, I will be supervised by Prof. Le Galès at Sciences Po’s Center for EU Studies and Comparative Politics, a top institute home to one of the largest multidisciplinary groups studying public policies at EU and city level. Besides enhancing my scientific knowledge and skills, as well as my international network and profile as independent researcher, thereby improving my career opportunities, the project will advance EU research excellence and raise institutional and public awareness about the need for governing the urban dimension of EU law. I will distil findings in two journal articles, and formulate evidence-based proposals to govern the urban dimension of the EU in a policy brief. Dissemination to scientific and policy community will involve an urban lab and a multi-stakeholder conference. Communication to wider audiences will involve a course, a newspaper article, and interactive city maps.

Keywords: constitutional law eu law cities and law subsidiarity proportionality urban governance urbanization sustainability eu green deal city missions eu multilevel legal order eu policies
Controlling spin properties of molecules with quantum fields: ab-initio methodologies for spin polaritons (QED-Spin)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1499754.0
EU funding (EUR): 1499754.0
Participants: 1
Project status: SIGNED

The goal of QED-Spin is to build novel ab initio techniques to reveal effects induced by quantum fields on the spin properties of molecules. Quantum computing and spectroscopic techniques are just two of the main fields that stand to benefit significantly from advancements in spin engineering; a field that is currently at the science frontier both for experiments and quantum many body theory. In this project I will propose new strategies based on strong light-matter coupling to manipulate static and dynamical spin properties of molecules. The mission of QED-Spin is to explore, using advanced theoretical techniques, the phenomena that arise when quantum fields interact with the electronic and nuclear spins of molecular systems and their implications in chemistry, spectroscopy and spintronics. In particular the proposed techniques will represent a significant step forward toward a better manipulation of molecular spin qubits used in quantum information and energy and memory storage. They will also increase our current possibilities of control on the photochemistry of molecular systems. The effects induced on the nuclear spins will bring to the formulation of a novel and more selective nuclear magnetic resonance technique. The developed theoretical and computational techniques will provide, differently from the previously applied model treatments, new tools to quantitatively simulate spin properties of molecules. Combination of cavity quantum electrodynamics and accurate quantum chemistry methodologies will form the basis for the development of novel tools to interpret and design spin properties. Coupled cluster theory, configuration interaction and density matrix renormalization group approaches will be used. I believe that the results of QED-Spin will build the foundations for a new field of research -- cavity spintronics.

Keywords: molecular spin polaritons,cavity quantum electrodynamics,coupled cluster theory,density matrix renormalisation group,strong coupling,quantum cavity
Time, ethics and the brain: Understanding the Behavioral and Neural Effects of Temporal-Discounting on Moral-Conflict Decisions (TempMoralDecisions)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 232916.16
EU funding (EUR): 232916.16
Participants: 1
Project status: SIGNED

Moral-conflicts arise when individuals need to decide whether to perform actions that benefit themselves, yet at the price of possibly hurting others. The effects of temporal-delays in the outcomes of these decisions are critical, as real-life consequences often unfold over varying timeframes in everyday life, as well as in public-policy, healthcare and economic decisions. While temporal lags are known to affect subjective reward valuation, their effects on moral decisions with conflicting self-benefit and harm-to-others outcomes, remain unexplored. This project will investigate how individuals assign subjective value to delayed outcomes in such conflicts, focusing on the behavioural and cognitive biases that arise due to temporal-discounting, and aim to uncover the neural mechanisms underlying them. Participants will perform moral-decisions, choosing between small self-monetary rewards associated with an unpainful small shock to another individual, to a larger self-reward coupled with a more intense shock to the other, with varied time-delays in the different outcomes. By combining behavioural, fMRI and physiological methods, and integrating them with computational modelling approaches, we will obtain a comprehensive picture of the neurocomputational effects of temporal-discounting in this context, aiming to explain and predict individuals’’ decisions in single-trials. By revealing the effects of temporal-discounting on moral decisions, this project will offer insights for social neuroscience, psychology and neuro-economics, and real-life implications for everyday decision-making, as well as for long-term, high-impact decisions by policymakers. The project will be performed at the Social Brain Lab at the Netherlands Institute for Neuroscience, supervised by Prof C. Keysers and V. Gazzola, world-leading experts in social neuroscience, ensuring I will develop novel theoretical and methodological skills, having a valuable impact on my training and career advancement.

Keywords: social neuroscience,cognitive neuroscience,moral conflict,empathy,decision making,temporal discounting,fmri,computational modelling