Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Next Generation Stakeholders and Next Level Ecosystem for ColLaborative Science Education with Online Labs (Next-Lab)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Spain,Estonia,Germany,Cyprus,Switzerland,Finland,Greece,Belgium,France,Netherlands,United Kingdom,Portugal
Call: Technologies for Learning and Skills (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 6336337.5
EU funding (EUR): 4917713.0
Participants: 12
Project status: CLOSED

Next-Lab intends to change the educational landscape of science and technology education in Europe on a very large scale. The project offers a unique and extensive collection of interactive online (virtual and remote) laboratories that, through a process of mixing and re-use, can be straightforwardly and efficiently combined with dedicated support tools (learning apps) and multimedia material to truly form open, cloud-based, shareable educational resources with an embedded pedagogical structure. Next-Lab offers extensive opportunities for localisation and personalisation together with analytics facilities monitoring students’ progress and achievements. Next-Lab is designed to rely on full co-creation with users in combination with rapid development and testing cycles. Next-Lab builds on the highly successful (FP7) Go-Lab project that already offers online labs, inquiry learning apps, and authoring facilities for inquiry learning. To amplify the existing impact to the next-level innovation stage, Next-Lab extends the Go-Lab system with tools for the learning of 21st century skills, facilities for self- and peer-assessment and portfolio development, as well as opportunities to include learning by modeling. Next-Lab will cover secondary and also primary education, to ensure an early positive attitude towards science and technology and the continuous availability of innovative learning material throughout students' school career. To guarantee long-term impact, Next-Lab also addresses the teachers of the future by its presence in pre-service teacher training programs throughout Europe. To evaluate its impact, Next-Lab combines usage data analysis techniques for very large-scale pilots with in-depth, qualitative, case-based, assessments. Next-Lab prepares for a following sustainable stage of the product. As it builds upon and extends existing networks of teachers, professional associations, and policymakers, the impact of Next-Lab will be massive.

Keywords: stem,inquiry learning,21st century skills,online laboratories,teacher training,open learning environments,open educational resources,innovation
Information Sampling in Multiattribute Choice (INFOSAMPLE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany,United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-12-01
End date: 2024-05-31
Duration (months): 66.0
Total project cost (EUR): 1499345.0
EU funding (EUR): 185937.5
Participants: 2
Project status: SIGNED

Do we prefer a small flat with a short commute or a large house with a long commute? Many real-life decisions require combining information across different attributes. It has been shown that during such multiattribute decisions people serially attend to (or sample) a subset of the available information. The way this process takes place largely influences the final choice: for example, if the “commute” attribute is considered for longer, then the small flat will tend to appear better. Up to date, information sampling has been studied within the social sciences using eye-tracking techniques. However, in the context of choice tasks, the way eye fixations influence the upcoming choice is not precisely known and, thus, this line of research has not yielded any definitive mechanistic conclusions. Recently, theorists have proposed different mechanisms of information sampling but these proposals were not constrained by relevant data. I propose to fill this gap in a data-driven fashion by harnessing tools from sensory neuroscience. Using magnetoencephalography (MEG) we will simultaneously track the locus of attention and the tendency to choose one alternative over the other, during the entire time-course of a single multiattribute decision. This approach will enable us to unravel the computational and neural mechanisms that guide attention towards different aspects of a multiattribute choice problem. This project will yield a neurophysiologically detailed theory of multiattribute choice–from the level of neurotransmitters, to large-scale brain networks, to behaviour– that will ultimately shed light on century-long questions, such as why humans reverse their preferences irrationally, when irrelevant alternatives are added to the choice-set. The emerging framework will be useful to policy makers and practitioners, interested in a descriptively enriched model of choice; and to clinicians aiming to understand how information sampling goes awry in neuropsychiatric disorders.

Keywords: decision making,attention,mulitattribute choice,choice dynamics,magnetoencephalography,sequential sampling models
Training innovative future leaders in research and development of materials and implants for the spine (NU-SPINE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Switzerland,Switzerland,Sweden,United States,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2023-09-30
Duration (months): 57.0
Total project cost (EUR): 4272380.36
EU funding (EUR): 4272380.36
Participants: 9
Project status: SIGNED

This proposal aims to develop Early-Stage Researchers into innovative European leaders in biomedical engineering, with a focus on spinal devices. Synergies will be drawn from the involved high-quality research centres in the interdisciplinary fields of materials science, mechanical engineering and biology, which will permit acquiring expertise in the development and preclinical testing of such devices, with a focus on meeting current and future societal challenges related to implant longevity and biocompatibility. The training programme has been put together in close collaboration with the relevant industry, SME’s as well as larger enterprise, ensuring adequate exposure to these environments, through e.g. secondments, as well as a knowledge base permitting a seamless transfer into industry and fostering innovation. An expert in industrial engineering and management will undertake co-ordination of the innovation-related training as well as consist of an independent career coach to the young researchers. The growing elderly, more active population puts higher demands on implants, which need to last longer and provide an adequate biological response throughout their lifetime. Current solutions for the spine suffer from a variety of issues, such as implant subsidence as well as potentially detrimental metal ion release and wear products. The current proposal aims to provide alternatives to these, by developing novel materials and implants for the spine, which provide i) non-detrimental wear products and reduced metal ion release and/or ii) enhanced osseointegration. Since many implant failures can be linked to inadequate loading, considerable effort will be spent on developing methods that simulate more closely adverse and individual biomechanical environments, as well as adapting implant designs to these situations. Adequate biological response will be evaluated through in vitro and in vivo models, closing the circle of the pre-clinical testing value chain.

Keywords: spine,implants,materials synthesis,mechanical properties,tribology,corrosion,biology,fusion,coating,silicon nitride,alumina,ceramics,wear,osseointegration,numerical modelling
The Genomic Underpinnings of Convergent Evolution: Repeated Loss of Flight in Island Rails, the Greatest Avian Colonizers (FLIGHTLOSS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-06
End date: 2023-01-04
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Convergent evolution—when similar changes occur in independent lineages—may be caused by similar selection pressures resulting in the same adaptations. This is exemplified by the evolution of echolocation in bats and whales, and the evolution of flight in insects, bats, and birds. The phenotypic convergence in major traits is less well-understood at a molecular level, and cases of genomic convergence are rare. In this action, I will focus on rails, a family of birds that is outstanding in two respects: (1) They are extremely successful dispersers and have colonized hundreds or thousands of islands by flight. (2) If island conditions did not require a volant lifestyle, over time the developmental resource investment into the flight apparatus is reduced, and the flight capability often eventually entirely lost. The loss of flight has occurred repeatedly and independently at least 30 times, often over short evolutionary time scales (<125,000 years). I will combine field sampling with historic samples from the unique bird collection of the Natural History Museum of the UK, including six now extinct species. With an extended museomics approach, I will sequence and assemble whole genomes with large-fragment linked-reads, and then employ a novel whole-genome alignment-based annotation method, followed by identification of genes or regulatory elements as targets for selection for flightlessness, replicated over three different lineages of rails. This MSCA action will uncover the genomic underpinnings of recent loss of flight and address the fundamental question whether phenotypic convergent adaption is reflected by convergence at a molecular level. It will also assess the contribution of changes in amino acid sequence vs. changes in gene regulation. Understanding the genomic changes behind loss of flight can also offer unique insights into the original gain of flight in the transitional theropod dinosaurs, ancestors of modern birds.

Keywords: convergent evolution,loss of function
Geo-inspired pathways towards nanoparticle-based metastable solids (Genesis)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1999577.0
EU funding (EUR): 1999577.0
Participants: 1
Project status: SIGNED

Constant search of new solids is required to advance our knowledge in materials science, and then to stimulate progresses in fields like energy and environment. Genesis aims at expanding the collection of functional inorganic solids as nanoparticles by rational exploratory synthesis. The pivotal idea is to draw inspiration from the processes of solid formation encountered in natural geological processes, in order to set a framework of synthesis conditions prone to yield new nanoscaled solids. I focus on kinetically stabilized, metastable solids, which yield novel, sometimes surprising properties prone to deliver new functions. However, conventional solid-state syntheses use high temperatures that yield thermodynamic products, hence hampering the synthesis of metastable inorganic solids. This obstacle is even more significant when the solids possess complex structures, as is the case of non-oxides made of transition metals and boron, silicon or phosphorus. The known members of these families are made of covalent bonds that bring unique electrocatalytic properties. This motivates the search of ternary solids joining these elements. Their quest is a synthetic challenge that I will address by the discovery of new metastable covalent solids. To do so, I will set an original inorganic synthesis methodology by taking inspiration from the processes of crystallization of gems in molten salts, of lavas at high rate and of metamorphic rocks at high pressures to merge nanosciences and solid-state chemistry. Genesis will operate at the crossroad of three pillars: use of the surface energy of nanoparticles to stabilize solids that would be metastable in their extended form; establishment of liquid-phase syntheses at 300-1000 °C in mild conditions; use of high-pressure chemistry to stabilize new solids. Within this frame, I will develop new methods to screen in situ the reaction pathways and I will trigger a new reactivity between boron, silicon, phosphorus and nanoparticles.
MASS SPECTROMETRY WITHOUT LIMITS: Pioneer MS equipment and Automated Sample Preparation unit to boost New Therapies Development (MS-INFINITE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Modern medicine is evolving. Traditional drugs are small molecules with masses under 1 kDa. Emerging therapies increasingly rely on macromolecules 100 times this size: proteins, nanoparticles, viruses etc. Mass spectrometry is the primary tool for quantitative measurement in the pharmaceutical industry, generating revenues of €1.1Bn in 2015, but is failing to meet new demands. Conventional MS detectors become ineffective at 50 kDa making them incompatible with the emerging landscapes of biotechnology and nanomedicine. With a combined 70 years’ experience in analytical instrumentation, we plan to commercialise MS-INFINITE, our solution for large analyte mass quantification. MS-INFINITE is a multicomponent system, comprising a cryodetector MALDI-TOF mass spectrometer allowing 100% detection efficiency, regardless of molecular mass. MS-INFINITE also offers a pioneering calibration method, allowing concentration of specific constituents of large analytes to be quantitatively determined by MS for the first time (patent submitted). Through a unique business model, MS-INFINITE will generate revenue by selling an Automated Sample Preparation (ASP) unit to end-users, allowing non-specialists to reproducibly prepare clinical and pharmaceutical material for measurement. The market launch of MS-INFINITE’s ASP unit (2022) will bring the 1st revenues into our company, generating 18 new jobs, a cumulative profit of €11M, and a 5-years ROI of 5. Despite this, we believe our impact will be far more significant than company growth: MS-INFINITE has the potential to become the standard tool for quantification of analytes too heavy for existing mass spectrometers. With experts estimating that over 100 high molecular weight therapies will enter phase II or III clinical trials in 2020, our innovation will facilitate the development of pioneering advances in biotechnology and nanomedicine, allowing research to advance towards life-saving cures for cancer, Alzheimer’s and arthritis.

Keywords: mass spectrometry without limits,development of new thrapies,large analytes molecular weight determination
Improving the Innovation Management Capacities of SMEs (InnovImp)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Malta
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-05-01
End date: 2014-12-31
Duration (months): 8.0
Total project cost (EUR): 10500.0
EU funding (EUR): 8400.0
Participants: 1
Project status: CLOSED

The InnovImp proposal is designed to provide in-depth innovation management support services to SMEs based in the Maltese Islands due to an absence of such affordable assistance in the market. The proposal also outlines how beneficiaries of the H2020 SME Instrument will receive specific support by the Enterprise Europe Network through the supported coaching assignments addressing innovation weaknesses. The service portfolio outlined in the InnovImp proposal being funded under H2020, totally complements the other actions being funded under the COSME programme and the proposal ensures that the right synergies will be created to result in the desired impact particularly by removing the innovation management inefficiencies of the client SME. For instance, whereas under COSME new innovation opportunities through partnering may arise, the new services funded under this H2020 call shall enhance the innovation management performance of the enterprise. In this way making their innovation processes more effective and efficient or, specifically for the beneficiaries of SME instrument identifies barriers to might hinder the SME to realise economic impact from its supported project. InnovImp foresees the use of dedicated assessment tools to gauge gaps and weaknesses in the client's innovation process, and these will be based on the latest CEN definition of an innovation management system. The InnovImp proposal supports and endorses the objectives outlined in the Competitiveness of Small and Medium Sized Enterprises [COSME] and Horizon2020 [H2020] programmes which both anticipate new and enhanced support mechanisms to help European SMEs. Moreover the delivery of such services through the only Enterprise Europe Network in the Maltese Islands strengthens the relevance of this work programme since the Malta Network enjoys both an embedded position in the local advisory eco-system and significant proximity to the targeted client base.

Keywords: innovation management,competitiveness,growth,smes,internationalisation,enterprise europe network,key account management,sme instrument
Paramagnetic Species in Catalysis Research. A Unified Approach Towards Heterogeneous, Homogeneous and Enzyme Catalysis (PARACAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria,Germany,Germany,Spain,Germany,Spain,Italy,Italy,Belgium,Greece,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 2649371.04
EU funding (EUR): 2649371.04
Participants: 11
Project status: SIGNED

PARACAT aims at educating a group of young researchers to implement methods for cutting edge research in the field of catalysis, comprehensively exploring for the first time the role of open-shell species, an innovative area at the intersections between chemistry, physics and biology. The programme puts strong emphasis on ethics and social reflections by combining the scientific expertise of (bio)chemists, (bio)physicists and industrial partners with the input of an ethicist to form a new generation of scientists capable to take up appropriate societal responsibilities as experts in their field. PARACAT is set up by a consortium formed by 5 academic beneficiaries flanked by 1 research institute, 3 industrial organizations and 2 academic institutions as partners, collaborating in the research and training activities to offer 10 early-stage-researchers the possibility of being awarded with double doctoral degrees in two different European countries. The overall PARACAT programme will address the role of paramagnetism in catalysis with a focus on a knowledge-based bottom-up approach, integrating homogeneous, heterogeneous and bio-catalysis with the objective of 1) designing new catalysts based on earth abundant and safe elements; 2) discovery of new and more sustainable reaction pathways for the activation of small molecules and selective oxidations by learning from nature; 3) enabling new routes for polymerization and de-polymerization reactions. The training programme overcomes barriers between traditional disciplines providing top level tuition on topics spanning from advanced spectroscopic methods, synthesis and property characterization, to quantum chemical modelling, and on a full set of complementary skills .The goal is therefore to build a chain of knowledge whereby fundamental understanding is translated into practical applications by the synergistic interaction between academic and industrial partners, in an ethical and social dimension.

Keywords: heterogeneous catalysis,homogeneous catalysis,enzyme catalysis,open shell species,epr spectrosocopy,quantum chemical modelling
TRILLIO, a porTable pRescription assistant Improving heaLth of Europeans citizens by increasing therapeutic adherence in eLderly people and in patIents affected by chrOnic diseases (TRILLIO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Therapeutic adherence is defined as “the extent to which a person’s behaviour – taking medication, following a diet, and/or executing lifestyle changes, corresponds with agreed recommendations from a health care provider”. It is estimated that each year the poor adherence to medical treatments in Europe causes about 200,000 deaths and burdens on health expenditure up to 80 billion euro a year (AIFA source). TRILLIO is a therapeutic adherence device really similar to an “alarm clock”, thus really familiar for elderly. The TRILLIO device is provided with an app that optimizes the connections among various players and organizations who share a common goal: make sure a patient follows his or her pharmaceutical treatment plan. When it's time to take a drug, TRILLIO alerts the user with a sound and a visual alarm, while showing all the relevant information on its 2.7" e-paper display. If the user doesn't press the button on the device to turn off the alarm within ten minutes, TRILLIO automatically sends a notification to any family member connected to the system. TRILLIO has been already tested in Italy and received serval endorsement by organisations in Italy and abroad. We are a targeting and overall population composed by 150.000.000 European that are suffering from Chronic diseases, 50% of them have difficulties in following a therapy: we are addressing 0,2% of this market and we are aiming at selling 112.000 devices by 2023, that will generate 17M€ turnover. The Feasibility study will have the purpose to support us in completing the market analysis, in launching a small pilot (i.e. 500/1.000 users), in identifying suitable partners in Europe for wide demo site (i.e. hospitals) and in identifying the right partners for distributing TRILLIO in Europe. TRILLIO is brought on the market by LA COMANDA, an Italian startup established under the Italian act for innovative startup, whose founders are Carlo Brianza and Andrea Gaggi, former executives of Nokia mobile team.

Keywords: therapeutic adherence,mobile health,chronic diseases