Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
EU Calculator: trade-offs and pathways towards sustainable and low-carbon European Societies (EUCalc)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Italy,Switzerland,Bosnia and Herzegovina,Belgium,Belgium,Belgium,Hungary,Netherlands,Denmark,United Kingdom,United Kingdom
Call: Pathways towards the decarbonisation and resilience of the European economy in the timeframe 2030-2050 and beyond (H2020-SC5-2016-OneStageB, 2016)
Start date: 2016-11-01
End date: 2020-02-29
Duration (months): 40.0
Total project cost (EUR): 5875173.75
EU funding (EUR): 5283351.25
Participants: 16
Project status: CLOSED

EUCalc replies to topic a) Managing technology transition. The EUCalc project will deliver a much needed comprehensive framework for research, business, and decision making which enables an appraisal of synergies and trade-offs of feasible decarbonisation pathways on the national scale of Europe and its member countries + Switzerland. The novel and pragmatic modelling approach is rooted between pure complex energy system and emissions models and integrated impact assessment tools, introduces an intermediate level of complexity and a multi-sector approach and is developed in a co-design process with scientific and societal actors. EUCalc explores decisions made in different sectors, like power generation, transport, industry, agriculture, energy usage and lifestyles in terms of climatological, societal, and economic consequences. For politicians at European and member state level, stakeholders and innovators EUCalc will therefore provide a Transition Pathways Explorer, which can be used as a much more concrete planning tool for the needed technological and societal challenges, associated inertia and lock-in effects. EUCalc will enable to address EU sustainability challenges in a pragmatic way without compromising on scientific rigour. It is meant to become a widely used democratic tool for policy and decision making. It will close - based on sound model components - a gap between actual climate-energy-system models and an increasing demands of decision makers for information at short notice. This will be supported by involving an extended number of decision-makers from policy and business as well as other stakeholders through expert consultations and the co-design of a Transition Pathways Explorer, a My Europe 2050 education tool and a Massive Open Online Course.

Keywords: low carbon society and economy,climate policy,technology innovations,land use,food security,green growth,transsectoral trade offs,transparent modelling tool,co creation of pathways
Analysis of tridimensional changes caused by type 2 Diabetes-Associated varianTs (3D-ADAPT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Despite the worldwide growing incidence of type-two diabetes (T2D), the molecular mechanisms are largely unknown. Genome Wide Association Studies (GWAS) have identified dozens of loci harbouring common SNPs that affect T2D susceptibility. The host lab recently showed that many associated SNPs lie in clusters of islet-specific regulatory elements that form tridimensional chromatin structures in the nucleus. This project aims to evaluate how common genetic variation could impact the tridimensional chromatin structure and transcriptional activity at the level of broad regulatory domains, and ultimately assess its influence on T2D risk. To this end, allele-specific chromosome conformation capture maps will be developed and analysed together with existing reference regulatory datasets of expression profiles, histone modification marks and transcription factor occupancy in human islets. To further define the function of allele-specific interactions, genetic modification experiments will be carried out on selected disease-relevant regulatory elements. These studies can shed novel insights on how common sequence variation contributes to T2D susceptibility and can lead to the identification of novel non-coding functional variants.

Keywords: type two diabetes,gwas,snps,long range interactions,tridimensional structure
Developing science-driven therapies after trauma: Neural mechanisms underlying the modification of intrusive emotional memories (Farewell flashbacks)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 2
Project status: CLOSED

A hallmark symptom of posttraumatic stress disorder involves ‘recurrent, involuntary and intrusive memories of the traumatic event’, in their most extreme form referred to as ‘flashbacks’. At present, effective interventions to prevent the development of intrusive memory after trauma are lacking. The research aim is to develop innovative, science-based therapies for treating trauma-related psychiatric disorders, by using a multidisciplinary approach, combining advanced neuroimaging (fMRI) analyses with an experimental analogue for trauma (film footage with aversive content). Key to the proposed research are findings from basic neuroscience showing that consolidated memories can - upon their retrieval – enter a labile state, making them susceptible to interference. Recent finds from the supervisors lab show that the reconsolidation of trauma memory can be disrupted, resulting in fewer subsequent intrusions, by engaging participants in a visuospatial task (i.e., Tetris) after retrieving the memory. To understand the mechanisms underlying this effect, I aim to directly measure the neural processes involved in the modulation of consolidated emotional memory. This has the potential to yield major conceptual, clinical and methodological insights, and will advance my research skills. The acquired transferrable knowledge will form the basis of a future grant application fully supported by the supervisor, prof. Emily Holmes, towards the end of the fellowship and fuel my career as a future leader in mental health science. My training will include courses on advanced MRI, media training and project management, and disseminating my results through scientific papers, conferences, and the media. A fellowship at the Medical Research Council (MRC) Cognition and Brain Sciences Unit (CBU) in Cambridge would help me establish an network with leading scientists from all over the world, while being based at a premier establishment for clinical psychology research and neuroscience.

Keywords: memory plasticity,functional magnetic resonance imaging,trauma film paradigm,experimental psychopathology,behavioural intervention,intrusive memories,memory reconsolidation
Pathophysiology of Primary Aldosteronism (PAPA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 2496875.0
EU funding (EUR): 2496875.0
Participants: 1
Project status: SIGNED

Arterial hypertension is a major cardiovascular risk factor that affects between 10-40% of the population. Primary aldosteronism (PA) due to adrenal excess production of aldosterone is the most common secondary form of hypertension affecting 4-12% of hypertensives. Given the severe cardiovascular adverse effects of aldosterone excess early detection and individualized treatment of PA has important impact on clinical outcome and survival. However, the pathophysiology of PA is not well understood: While we recently identified specific genes underlying aldosterone producing adenoma, the most prevalent form of PA, bilateral adrenal hyperplasia, has remained enigmatic. It is the first hypothesis of this proposal that the pathophysiology of PA is a process based on two ‘hits’: agonistic angiotensin II type 1 receptor (AT1R) autoantibodies (proliferation, nodular hyperplasia) and somatic mutations (adenoma formation). It is the second hypothesis, that together, both factors induce not only aldosterone but also marked glucocorticoid excess. 1.) I will analyze prevalence and binding characteristics of AT1R autoantibodies as a pathophysiologic basis of PA. 2.) I will determine the effect of AT1R antibodies and genetic factors on cellular adrenal cortex models in vitro. 3.) I will extend these studies to specific in vivo genetic rodent models of PA. 4.) I will quantify aldosterone and glucocorticoid excess as disease effectors of AT1R autoantibodies and somatic mutations using liquid chromatography–mass spectrometry in PA. 5.) Using the generated data I will develop a pathophysiology-based concept of PA. This groundbreaking approach using innovative in vitro and in vivo models, state-of-the art genetic, immunologic and steroidobolomic techniques will uniquely open new avenues to the pathophysiologic understanding of PA. It will change our current understanding of PA, has high health impact and, thus, will pave the way to novel concepts of aldosterone excess and hypertension.

Keywords: endocrine hypertension,primary aldosteronism,cortisol,aldosterone
Table Top Device based on Nanostructured Sensors for the continuous ENvironmental monitoring of EXplosive substances in sensitive areas (SENEX)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Italy
Call: Critical infrastructure protection topic 7: SME instrument topic: “Protection of Urban soft targets and urban critical infrastructures” (H2020-SMEINST-1-2014, 2014)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

SENEX Project aims at the industrialization of an innovative table top explosive trace detector that exhibits remarkable and competitive performances in sensitivity and specificity, besides a compact and low-cost architecture. The SENEX device is based on surface plasmonic resonance phenomenon and it fills the growing need of security professionals to have the ability to detect a wide range of explosive substances and to be able to adapt as threats and their needs change. By the use of an innovative automatic microelectronic system based on nano-structured sensors, SENEX system is capable of continuously detecting and identifying explosives during a single analysis, while maintaining high sensitivity. SENEX device has the potential to satisfy all the requirements for the trace detection of explosives because it can overcome all the technical and commercial barriers connected to use of conventional sensors based techniques: Ion Mobility Spectrometry, Gas Chromatography, Computer Tomography, Colorimetry and Chemi-Luminescence. Most of the existing devices are bulky, expensive and require long lasting procedures and complex training activities in the start-up phase. SENEX technology first key market application is transportation security in airports and harbours to detect explosives, weapons, and illegal items in baggage or on passengers, airports threat areas are; another key market application is the freight terminal sectors where currently security explosive controls are often lacking.

Keywords: nano sensors,explosive detection,explosive trace detector,surface plasmon resonance,airport security,harbour security
Development and Demonstration of Highly Insulating, Construction Materials from Bio-derived Aggregates (ISOBIO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies enabling energy-efficient systems and energy-efficient buildings with a low environmental impact
Action type: Innovation actions
Countries involved: Spain,Spain,Germany,Belgium,Belgium,Norway,France,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Materials for building envelope (H2020-EeB-2014, 2014)
Start date: 2015-02-01
End date: 2019-01-31
Duration (months): 48.0
Total project cost (EUR): 6286320.5
EU funding (EUR): 5470127.0
Participants: 17
Project status: CLOSED

The ISOBIO project will develop a new approach to insulating materials through the novel combination of existing bio-derived aggregates with low embodied carbon with innovative binders to produce durable composite construction materials. These novel composites will target 50% lower embodied energy and carbon than traditional oil based insulation panels, and will increase thermal insulation compared with traditional systems by at least 20%. By using bio-based materials, using vertical integration from raw material production through to finished systems, the ISOBIO project aims to reduce costs by at least 15% over traditional systems. The use of bio-based materials ensures that whole life energy use is reduced through taking advantage of the photosynthesis of atmospheric carbon which is sequestered in the fabric of the building for its lifetime. The ISOBIO materials take advantage of the natural moisture sorption/desorption characteristics of bio-based materials, which is known to passively manage the indoor environment resulting in greatly improved indoor air and environmental quality, whilst at the same time reducing the demand for air conditioning.

Keywords: insulation,low carbon,composite,construction,bio aggregate,moisture sorption,environmental quality,air quality,carbon sequestering,modular construction,panel,render
Search and Rescue: Emerging technologies for the Early location of Entrapped victims under Collapsed Structures and Advanced Wearables for risk assessment and First Responders Safety in SAR operations (Search and Rescue)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Increase Europe's resilience to crises and disasters
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Italy,Italy,Italy,Austria,Germany,Italy,Estonia,Ireland,Cyprus,Greece,Belgium,Belgium,Poland,Greece,Romania,France
Call: Technologies for first responders (H2020-SU-SEC-2019, 2019)
Start date: 2020-07-01
End date: 2023-06-30
Duration (months): 36.0
Total project cost (EUR): 7890585.0
EU funding (EUR): 7890585.0
Participants: 30
Project status: SIGNED

Apart from earthquakes that usually result to catastrophic structural collapses, with many people entrapped or killed (e.g. Indonesia 2018, Japan 2011, Haiti 2010, Italy 2009, Greece 1999), there are also other causes that may result into a building’s collapse, such as an accidental explosion or a terrorist attack (e.g. 9/11) in public areas or critical infrastructures (airports etc.). Moreover, natural disasters like earthquakes may trigger technological disasters, such as industrial chemical release or even fires; this dynamic or “domino effect”, as it is called may pose tremendous risks to the countries and communities and hence it is a great challenge to cope with by the first responders and relevant organizations of civil protection. First responders and rescuers need specialized instrumentations, available to all times, easily accessible that meet stringent requirements in terms of detection accuracy, quick localization, and reduction of false alarms. The S&R project will design, implement and test through a series of large scale pilot scenarios a highly interoperable, modular open architecture platform for first responders’ capitalising on expertise and technological infrastructure from both COncORDE and IMPRESS FP7 projects. The governance model of S&R will be designed to operate more effectively and its architectural structure will allow to easily incorporate next generation R&D and COTS solutions which will be possibly adopted in the future disaster management systems. The Model will also support a unified vision of the EU role and will provide a common framework to assess needs and integrate responses. The framework will enable supportive approach using a wider range of decisional support features and monitoring systems and will also give to first responders an effective and unified vision of (a) the dynamic changes going on during event’s lifetime and (b) the capabilities and resources currently deployed in the field.

Keywords: crisis management,technologies for first responders
International Re-Entry demoNstrator Action (IRENA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European research in support of international space partnerships
Action type: Coordination and support actions
Countries involved: Italy,Germany,Greece,France,France,Japan
Call: Technology “demonstrator projects” for exploration (H2020-COMPET-2014, 2014)
Start date: 2015-01-01
End date: 2016-04-30
Duration (months): 16.0
Total project cost (EUR): 862058.75
EU funding (EUR): 823608.75
Participants: 6
Project status: CLOSED

In January 2014, the ISEF participants insisted on the importance of “fostering international cooperation for additional space exploration projects”. The partners of IRENA (International Re-Entry demoNstrator Action), including major space agencies involved in ISEF and ISECG, are convinced of the need for demonstrators in atmosphere entry/re-entry and of the potential for international cooperation in this area. IRENA mainly aims at: - creating a cluster of European and international stakeholders to study two types of demonstrators aimed at developing entry/re-entry technologies and suitable for other enabling technologies - jointly defining two technology demonstrator projects relevant for international cooperation - contributing to a European position for ISEF and - disseminating the results and preparing the next steps. To achieve these objectives, IRENA will rely on an international and complementary team: four major European and international space agencies (CNES, DLR and JAXA as beneficiaries and NASA as a 3rd party), the two European industry leaders in entry/re-entry and space exploration (Astrium, Thales Alenia Space) and a research institute expert in dissemination and exploitation. IRENA will build on a cooperative approach to jointly define the projects, on feasibility and cost assessment studies and on implementation assessment studies (governance, funding, international cooperation). Five workshops including one in Japan, the USA and two based on Concurrent Engineering will be used to support the work. IRENA’s objectives have been chosen to explicitly meet the main work programme's requirements i.e. to be in line with ISEF recommendations, to involve international countries active in space exploration, to create a cluster around several demonstrator projects, to define these projects and discuss how to build them, to target enabling technologies and to include workshops and information events.

Keywords: cluster,japan,entry,re entry demonstrator projects,international cooperation
European Research and Preparedness Network for Pandemics and Emerging Infectious Diseases (EU-RESPONSE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Ireland,Italy,Austria,Switzerland,Norway,Türkiye,Belgium,Greece,Hungary,Poland,Slovakia,France,France,France,Czechia,Czechia,Portugal,Luxembourg,Portugal
Call: Advancing knowledge for the clinical and public health response to the 2019-nCoV epidemic (H2020-IBA-SC1-CORONAVIRUS-2020-3, 2020)
Start date: 2020-07-01
End date: 2025-06-30
Duration (months): 60.0
Total project cost (EUR): 16055304.1
EU funding (EUR): 15719450.0
Participants: 27
Project status: SIGNED

The overall objective of this 5-year project is to build a multinational, adaptive European COVID-19 and emerging infectious diseases trial network, based on existing initiatives, experience and expertise, allowing European expansion of DisCoVeRy (WP1) and the establishment of a COVID19 adaptive platform trial (WP2). The DisCoVeRy trial, designed as a multi-arm adaptive repurposing trial, initiated in France, has the potential to expand to many other European countries with appropriate support in terms of multinational funding and trial management capacity. This will complete the evaluation of repurposed drugs, while building a European clinical trial network which, together with other European networks such as the Solidarity trial, will design and run a new European platform trial. EU-RESPONSE will swiftly generate robust evidence for drug repurposing or registration, through a modular trial framework allowing most European hospitals to participate at their preferred level of commitment, thus building a network of investigation sites within European and associated countries. Cooperation with other European platforms, in particular the RECOVER consortium platform will be achieved through a joint coordination mechanism aligned with European and national policies (WP3), ensuring a coordinated strategy for the European COVID-19 Adaptive Platform Trials, their complementarity in providing access for requests for a new domain or arm, their synergy and cross-fertilization through the development of a common toolbox for the development and the management of Adaptive Platform Trials. Joining forces in Europe and with international partners, it will contribute to the global clinical trial capacity for urgently meeting the expectations of society and developers. It will also boost multinational cooperation in Europe and promote the establishment of adaptive platform trials in other diseases, and will have a major impact on epidemic control.

Keywords: covid 19,platform trials network,emerging infectious diseases