Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The eye as a window to the brain, extending lifelong brain health (Nocturne)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Nocturne specializes in products and services that allow diagnosing neurologic disorders through imaging of the eye. Nocturne’s proprietary technology (patent pending) analyses 3D images of the retina, which are obtained by optical coherence tomography (OCT). OCT is a noninvasive imaging technology routinely used in ophthalmology. Standard OCT devices are affordable but are by themselves of only limited value for neurologic applications. At market entry, Nocturne offers a web service, which accepts data from standard OCT scans. The data is then analyzed with Nocturne’s technology, and a report is sent back to the customer. With its service, Nocturne addresses customers in pharmaceutical research, academia, and clinical care. More than 10 million people suffer from neurological disorders such as multiple sclerosis, neuromyelitis optica, Parkinson’s disease, and Alzheimer, in Europe alone. Nocturne expects that its OCT-based retinal image analysis will allow neurologists short-term diagnostic decisions, which will reduce the need for external costly MRIs. The ultimate goal is to offer specialized OCT devices in the future.

Keywords: digital health,neurological diseases,diagnosis,monitoring,mathematical modeling,deep learning
Overcoming and Compensating in academia Weaknesses (OCAWADHD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Action type: Marie Skłodowska-Curie actions
Countries involved: France
Call: MSCA Special Needs Allowance (H2020-IBA-MSCA-SNLS-2020, 2020)
Start date: 2021-02-15
End date: 2024-04-14
Duration (months): 38.0
Total project cost (EUR): 12160.0
EU funding (EUR): 12160.0
Participants: 1
Project status: SIGNED

Request of financial support to cover the additional costs that researchers/staff members with disabilities face due to the increased costs of their mobility and/or to ensure necessary assistance by third persons or for adapting their work environment.

Keywords: attention deficit and hyperactivity disorder,neurodiversity
REAL-time discovery strategies for DARK matter and dark sector signals at the ATLAS detector with Run-3 LHC data (REALDARK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Sweden,United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-11-01
End date: 2026-10-31
Duration (months): 60.0
Total project cost (EUR): 1999777.0
EU funding (EUR): 1999777.0
Participants: 2
Project status: SIGNED

The Standard Model of Particle Physics (SM) describes the fundamental particles and interactions of ordinary matter. Despite the SM's success in predicting experimental results, it fails to account for the large abundance of dark matter in the Universe. Dark Matter (DM) particles could be created from collisions of SM particles, such as in the Large Hadron Collider, but storage and computing limitations mean that rare processes involving DM may be missed by current data-taking methods. In REALDARK, I will consolidate my leadership in DM searches with innovative data-taking techniques in order to solve these problem for the ATLAS experiment. The technical innovations from this proposal will be widely disseminated, paving the way to advancements for future experiments. Under my leadership, the REALDARK team will break the traditional paradigm of recording detector data and then analyzing it in separate steps, by deploying data processing in real-time so that far more collision data can be searched for rare processes. We will enable new types of datasets from the upcoming LHC data-taking period and search them for new phenomena, motivated by theories of weakly interacting massive DM particle candidates and by "dark" sectors inaccessible to ordinary particles. The proposed searches will yield either a discovery of dark matter candidates, to be studied in connection with astrophysical observations, or world-leading constraints on the particle nature of dark matter, focusing theoretical efforts and search targets for future experiments.

Keywords: atlas,trigger,dark matter,data analysis
Improving therapy of NPM1-mutated AML (TREAT-NPM1-AML)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Italy
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-11-01
End date: 2022-10-31
Duration (months): 60.0
Total project cost (EUR): 2895836.0
EU funding (EUR): 2895836.0
Participants: 2
Project status: CLOSED

Acute myeloid leukemia (AML) is the most common acute leukemia in adults accounting for approximately 15,000 new cases/year in Europe and 20,000 new cases/year in US. Currently, 40-50% of AML patients (age 18-60 years) and only 5-10% of older patients (who are usually more frequently affected by the disease) can be cured using conventional chemotherapy +/- allogeneic hematopoietic stem cell transplantation. Thus, AML still remains an urgent medical need which calls for new forms of molecular targeted therapies (similarly to those available for acute promyelocytic leukemia). The P.I. previously discovered the nucleophosmin (NPM1) mutations, the most common genetic lesion in AML (about one-third of cases) and gave fundamental contributions in the translation of this seminal discovery into the clinic (improved classification of myeloid neoplasms according to WHO, genetic-based risk- stratification of AML patients, monitoring of minimal residual disease and first demonstration of the anti-leukemic activity of actinomycin D). The present research proposal is focused on improving therapy of NPM1-mutated AML. Specifically, it is aimed to: i) identify novel chemical tools interfering with NPM1 functions by interacting with the N-terminal portion of the protein (objective 1); ii) conduct a clinical trial (AML-PG02; Eudract 2014-003490-41) with actinomycin D in older untreated and/or unfit patients with NPM1-mutated AML and to better understand in vitro and in mice models the mechanisms of action of this drug, used alone or in combination with other agents (objective 2); iii) develop compound mouse models aimed to investigate how NPM1 mutations cooperate with FLT3-ITD or DNMT3A mutations in promoting AML with the goal to better understand the characteristics of relapsed cases and to design new therapeutic strategies (objectives 3 and 4): and iv) generate a murine model for testing the feasibility of “in situ” vaccination in AML, especially in NPM1-mutated AML (objective 5).

Keywords: acute myeloid leukemia,npm1,gene mutations,target therapy,immunotherapy,preclinical,models
Rare Earth Supply Chain and Industrial Ecosystem: A Material Flow Assessment of European Union (REE Value Chain)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Europe is the leading importer and consumer of rare earth minerals both in mineral and applied forms. Europe is almost dependent on others for imports of these mineral resources, despite the fact that engineering and manufacturing are backbone of many European economies. The criticality of these minerals were highlighted in European Commission’s Report of the Ad hoc Working Group on defining critical raw materials published in 2010 as well as 2014. E.U’s primary end use application of REEs includes polishing, metal alloys, magnets, and catalysts. Highest demand growth is foreseen in high tech-electric/hybrid vehicle motors, magnets, phosphors and ceramics end-markets. Though these raw materials are fundamental to Europe’s economy, growth and jobs, the importance of these minerals to European economy has never been studied thoroughly. However, responses have been initiated in different nations, economic areas and companies, with the European Commission launching the “Raw Materials Initiative (RMI)”. European Commission has identified criticality of raw materials to boost the innovation capacity of the EU along with addressing entire raw materials value chain in the Raw materials part of the Societal Challenge 5 of Horizon 2020. Therefore an empirical study on rare metals including rare earth elements and its importance to European economy in terms total demand, the issue of stable supply, recycling capacity of European companies, value addition and value chain management become important aspects to study and applying an input-output matrix and network diagram, the study will trace the entire value chain of the identified minerals from mining to intermediate products to final products and calculate the value addition in each stage

Keywords: rare earth elements,value chain,material flow assessment
Cocoro Advanced Lingerie, the ultimate reusable absorbent underwear (COCORO)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Disposable menstrual products represent around 1M of the 3B tons of waste produced in the EU every year. Mostly composed by highly pollutant plastics, they have a huge impact on the environment. The pollution and greenhouse gas emissions they cause contribute to climate change, as well as material loss – a significant problem in the EU, which is highly dependent on imported raw materials. Moving towards a circular economy is an urgent need for the feminine hygiene industry to contribute to the competitiveness of the EU economy. Only two new companies in the US and Australia have recently started selling absorbent underwear as an alternative to pads. Yet, they cannot fully compete with pads given their insufficient absorption capacity and practicality. These products are also very expensive to get in Asian and European markets, which are the largest pads markets. Femmefleur has developed the ultimate alternative to disposable external menstrual hygiene management (MHM) products: a highly absorbent, breathable, practical and comfortable reusable underwear. Cocoro Advanced Lingerie uses a combination of cotton and polyester treated with an innovative technology that absorbs corporal fluids like menstruation or slight urine loss, satisfying women’s needs in MHM and beyond. Its unique features are highly competitive as our disruptive technology and design guarantee a cost-effective and ecological solution for MHM. Increasing their absorption capacity, these panties can be commercialized in other market segments such as urine incontinence or maternity. This translates into a high-potential users group, as only in the EU it represents around 190M people. The successful results gathered together with the huge business opportunity ahead allow us to establish two main goals for this SME Inst. phase 1: to finalise a techno-economic assessment of the polyester fabric technology and to corroborate the feasibility of the developed commercial strategy for the MHM market.

Keywords: menstrual products,reusable,absorbent underwear,feminine hygiene,innovative technology,disruptive technology,menstrual hygiene management,technical fabric
Affordable zero energy buildings (A-ZEB)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Italy,Spain,Spain,Spain,Germany,Bulgaria,France,Netherlands
Call: Cost reduction of new Nearly Zero-Energy buildings (H2020-EE-2016-CSA, 2016)
Start date: 2017-05-01
End date: 2020-04-30
Duration (months): 36.0
Total project cost (EUR): 1979222.5
EU funding (EUR): 1979222.5
Participants: 9
Project status: CLOSED

Project Proposal: Affordable Zero Energy Buildings (A-ZEB) This project aims to achieve significant construction and lifecycle cost reductions of new NZEB’s through integral process optimization in all construction phases. The main objectives are: a) To develop a methodology for cost reduction in synergy with better energy/ grid-interaction/comfort/environmental performances of new NZEB’s for the European climate zones with a framework of tested strategies and technologies from which designers, builders and urban planners may combine the best for their context. b) To disseminate the gained and consolidated knowledge and experience as market-ready solutions to the widest possible EU audience and this way inspire stakeholders to take up new NZEB’s with RES concepts and implement the cost-effective solutions. c) To facilitate frontrunners and innovators, from policy-makers to progressive contractors, to help transform the building sector into a sustainable industry, with ready-to-use material and strategies to influence their target groups. Optimizing construction processes to fully integrate available solutions (in the areas of process, technology, contracting) is seen as the largest potential in lifecycle cost reduction and is at the core of the project. A-ZEB proposes to create a common methodology on this. The main steps are: - Evaluate available experience and solutions - Create a common methodology for cost reduction - Apply the methodology to demonstration projects - Finalise the methodology including lessons learned - Disseminate the results The project will pave the way for the process and organizational innovation in construction, to enable significant cost-reduction and solid market acceptance of NZEB’s.
Mapping and Assessment for Integrated ecosystem Accounting (MAIA) (MAIA)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Protection of the environment, sustainable management of natural resources, water , biodiversity and ecosystems
Action type: Coordination and support actions
Countries involved: Germany,Spain,Germany,Greece,Bulgaria,Norway,Norway,Belgium,Belgium,Finland,France,Czechia,Netherlands,Netherlands,United Kingdom
Call: Valuing nature: mainstreaming natural capital in policies and in business decision-making (H2020-SC5-2018-1, 2018)
Start date: 2018-11-01
End date: 2022-10-31
Duration (months): 48.0
Total project cost (EUR): 3002007.5
EU funding (EUR): 3002007.5
Participants: 21
Project status: CLOSED

MAIA (Mapping and Assessment for Integrated ecosystem Accounting) aims to mainstream natural capital and ecosystem accounting (NCA) in EU member states. MAIA uses the System of Environmental Economic Accounting – Experimental Ecosystem Accounting (SEEA-EEA) as the methodological basis for NCA. The SEEA EEA provides a consistent framework for analysing and storing information on ecosystem assets and flows of ecosystem services, in both physical and monetary units. The SEEA EEA follows a spatial approach, requiring extensive (spatial) data and models as inputs into the accounts. In MAIA, a flexible approach will be followed, allowing for adaptation of the SEEA EEA framework to the conditions of individual EU countries. In particular, MAIA will: (i) assess policy priorities for accounting; (ii) test, pilot and mainstream NCA in 10 countries; (iii) test innovative approaches for NCA in the European context; and (iv) support NCA in the EU through various communication and dissemination activities including the development of guidelines, a web-based information system and other facilitating actions. MAIA will involve in-country work in Belgium, Bulgaria, Czech Republic, Finland, France, Germany, Greece, the Netherlands, Norway and Spain but there will be outreach to all EU member states through exchanging data, guidelines and experiences. The MAIA consortium includes a balanced mix of partners with backgrounds in statistics, ecological modelling and environmental economics, including three statistical agencies. In addition, MAIA has 18 supporting partners including statistical and other government agencies in 10 countries. Institutes with more experience will mentor and assist those with less experience. MAIA partners are involved in a range of other initiatives such as the SEEA London Group, MAES, ESMERALDA and IPBES, and includes partners supporting KIP INCA, which will facilitate exchanging experiences. Overall coordination of MAIA is with Wageningen University.

Keywords: natural capital accounting
Artificial Intelligence approach for Product Inspection through the use of Cobot enabling quality control of Unshaped products Solution (APICUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Handling a product to perform entire quality controls at the end of production processes has been a human prerogative. Complete integrity is paramount for hollow glass containers, used as packaging for food&beverages, perfumery and pharmaceutics, to ensure shelf-life properties and safety of products for costumers. Following the market needs for customization, non-standard containers are increasing and posing new challenges for quality controls. Current technologies are limited to examine standard shapes and specialized per type of defects causing false positives phenomena, increasing production costs and slowing-down times. Video Systems aims to develop an innovative inspection system for the cold-end and the reselection phase, APICUS, with no comparable solution. It is a collaborative robot, empowered by artificial intelligence and artificial vision, able to handle a glass article in a human-like way and detect all potential defects, cutting down false positives to 0.1% and speeding up processes. APICUS is expected to revolutionize quality controls contributing to the paradigm of Zero-Defect Manufacturing. First market applications are projected to be hollow glass and white goods sectors, with GISAL, Nordfish, Stazione Sperimentale del Vetro, Vetri Speciali already interested in the solution. With an initial market share of 30% corresponding to non-standard shapes of hollow glass at present controlled manually, it has other potential market applications like tile, automotive and aerospace industries. Our team will capitalize on years of researches in data mining, artificial intelligence, hyperspectral vision and software development. APICUS will boost our growth with an expected turnover of €8 million by year 5 from the commercialization and 14 more jobs created. During Phase 1 we aim to finalize technological and economic viability assessments, whereas during Phase 2 to reach a market readiness level to launch APICUS in European and international markets.

Keywords: artificial intelligence,artificial vision,collaborative robot,intelligent algorithms,quality control,automation,defects inspection,hollow glass,flat glass,white goods industry
Novel photo-assisted systems for direct Solar-driven redUctioN of CO2 to energy rich CHEMicals (SUN2CHEM)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Spain,Singapore,Sweden,China,Switzerland,France,France,Netherlands,Denmark,United Kingdom,Japan
Call: Converting Sunlight to storable chemical energy (H2020-LC-SC3-2019-NZE-RES-CC, 2019)
Start date: 2020-10-01
End date: 2024-04-30
Duration (months): 43.0
Total project cost (EUR): 3941507.5
EU funding (EUR): 2998445.0
Participants: 15
Project status: SIGNED

Gathering 15 partners from 9 European and associated countries and 3 from Asian countries, SUN2CHEM’s main objective is to develop solutions to achieve efficient solar-driven CO2 reduction, targeting ethylene as the final product. Ethylene, an energy-rich chemical produced from fossil fuels in industry, has both high commercial value and a giant global market. SUNCHEM’s ambitions will simultaneously reduce our dependence on fossil fuels and mitigate carbon emission by CO2 conversion. For that purpose, SUN2CHEM partners will conjointly develop all the components to be integrated into tandem photoelectrochemical (PEC) cells and advanced photocatalytic (PC) reactors. The technical part of this project includes applied and fundamental research on photocatalysis to improve light-harvesting and charge separation in heterojunctions and plasmonic bimetallic nanoparticles united in a PC reactor (WP2). Next WPs focus on the development of up-scalable efficient and stable photoelectrodes (WP3) and the design of earth-abundant catalysts (WP4), which will then be integrated into the tandem PEC (WP5). Both PC reactor and PEC device will be tested and characterised in operating conditions (WP6). In addition to this highly technical core, this project has for ambition to perform related environmental and social studies in order to integrate the developed technology within a context of circular economy, assess the energy security impacts on end-users and increase the social acceptance of chemicals produced from sunlight conversion (WP7). A prospective market analysis and roadmap towards the upscaling of the technology will then evaluate its medium-term potential and establish pathways towards its future industrial development (WP8). Achieving these ambitious developments by tackling photo-electrochemical cells, catalysts for CO2 reduction, light-harvesting and charge separation, SUN2CHEM will contribute answering Mission Innovation’s Converting Sunlight Innovation Challenge.

Keywords: ethylene,polymers,fuel,photocatalysis,photoelectrochemical,photosynthesis