Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Modeling TEL/AML1 childhood lymphoblastic leukemia in zebrafish (ALLRUN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-02-01
End date: 2016-01-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Acute lymphoblastic leukemia is the most common childhood malignancy and is diagnosed in about 5000 children in Europe every year. The most frequent B-type acute lymphoblastic leukemia, called TEL/AML1, is due to a chromosomal translocation that results in the fusion of two transcription factors, TEL with AML1 (also called RUNX1). Most treatments of TEL/AML1 acute lymphoblastic leukemia result in a good outcome, although some patients suffer very late relapse which cannot be anticipated at the diagnosis. Anticipating and treating the late relapse is a real therapeutic challenge. Understanding the pathogenesis of TEL/AML1 will allow anticipating the late relapse and proposing adjusted therapy and new targeted therapy. TEL/AML1 translocation leads to increased expression of the normal allele of AML1. AML1 is a major transcription factor for hematopoiesis. AML1 impairments are found in many acute leukemia: lymphoblastic, myeloid, and megakaryoblastic. Finally, amplifications of AML1 in other B- acute lymphoblastic leukemia are suspected to worthen the prognosis. My goal is to address the question of TEL/AML1-associated leukemogenesis by characterizing the cooperation between AML1 and TEL/AML1 in an innovative pathophysiology approach. We will combine molecular and cellular biology approaches with physiological approach in zebrafish, and validation in human samples. We will use TEL/AML1 transgenic zebrafish that is the only model of TEL/AML1 leukemia available. We will focus on studying the rate of onset of leukemia, change in proliferation, survival and differentiation of lymphoblasts in dual transgenic TEL/AML1 and AML1 zebrafish. We will validate the results in a large cohort of human TEL/AML1 pre-B acute lymphoblastic leukemia samples. This study will provide new insights on how AML1, a key player of hematopoiesis, affects the molecular pathogenesis of TEL/AML1-induced leukemia. The zebrafish model will permit us to identify major players required for leukemia.

Keywords: health sciences,hematology,leukemia,childhood,tel/aml1,tel,aml1,runx1,etv6,zebrafish,leukemogenesis
European Research Area - Network on the Industrial Handling of Raw Materials for European Industries (ERA-MIN)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Coordination and support actions
Partnership: ERA-MIN (ERA-NET)
Countries involved: France,Netherlands,Finland,Germany,Sweden,Hungary,Poland,Germany,Spain,Portugal,Sweden,France,Romania,Türkiye,Slovakia
Call:  (FP7-ERANET-2011-RTD, 2011)
Start date: 2011-11-01
End date: 2015-10-31
Duration (months): 48.0
Total project cost (EUR): 1692771.58
EU funding (EUR): 1490000.0
Participants: 15
Project status: CLOSED

ERA-MIN will, for the first time, bring together a significant number of funding / programming agencies in support of the development of the European non-energy mineral raw materials research area and provide a discussion forum with other European stakeholders involved in non-energy mineral raw materials research. It will aim at building a mirror group to the ETP-SMR, and liaise with non-energy mineral raw materials relevant European Commission (EC) policies and programs as well as with the projects funded by the EC. This will clearly contribute to pool EU capacities, foster EU competitiveness in line with sustainable development ethics, and contribute to the EU security of supplies. ERA-MIN will contribute to the “Raw Materials for a Modern Society” Partnership Initiative“ as it develops, providing inputs from national and regional research programming agencies and their related expert institutions, establishing comprehensive coordination as a permanent feature of the European non-energy mineral raw materials research community (ENERC). ERA-MIN will provide systematic information on its activities to the ESFRI, the OECD Global Science Forum, and the ERC. ERA-MIN will pave the way for coordinated actions between several of its participants, as well as pan-European programs, in the domains of research, outreach, training, mobility, or evaluation procedures. Through these measures, ERA-MIN will help to mobilise the intellectual resources of the whole of Europe in the preparation of the plans for the future, needed to address the non-energy mineral resources related global challenges; and foster initiatives by which a unified Europe will be progressively able to act as an equal partner in collaborative enterprises with the USA, Japan, and developing countries. It will as well be a source of support to developing countries in line with the Action Plan decided by the African and EU in November 2010.

Keywords: non-energy mineral raw material,mineral supply,recycling,substitution,resource efficient manufacturing,sustainable environment monitoring,education,training,public/societal involvement,marine
Use of newly designed organic molecules as large and efficient structure directing agents for the synthesis of microporous aluminophosphates (NEWSDASFORALPOS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-09-01
End date: 2013-08-31
Duration (months): 24.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

We aim to develop new large and efficient structure directing agents (SDAs) for the specific synthesis of microporous aluminophosphates (AlPOs). New concepts will be used for designing new types of SDAs in a search for extra-large-pore microporous aluminophosphates, in line with the search for tailored materials proposed in the Work Programme. AlPOs have unique chemical properties that differentiate them from their zeolite counterparts, remarkably a high hydrophilic nature. We will explore the chemical uniqueness of these AlPO networks in a search for SDAs specifically designed for this type of materials. Three different concepts will be investigated. First, we will explore supramolecular chemistry issues in order to get extra-large SDAs. We will use molecules bearing large aromatic moieties, which are able to self-assemble through π-π type interacions, and thus will form larger molecular entities that will act as SDAs. We will then introduce fluorine atoms in those aromatic rings in an attempt to enhance the molecular aggregation, since it is known that organic F atoms tend to aggregate by developing non-bonded F---F interactions in aqueous media. Second, N-containing molecules bearing hydrophilic groups, such as hydroxyl substituents, will be used in an attempt to maximise the interaction with the hydrophilic AlPO network in order to enhance the structure directing ability of the SDAs. An interesting example of this type of SDAs will be provided by the use of aminosugars, which contain an amino group, required for providing a basic character, and many outermost hydroxyl groups that will potentially enhance the interaction with the hydrophilic framework. Once understood these concepts, they will be combined in order to get large (through aggregation) and efficient (through OH groups) SDAs that will potentially lead to extra-large-pore AlPO structures. A combination of experimental and computational works will ensure a satisfactory progress of the research.

Keywords: computational chemistry,heterogeneous catalysis,inorganic chemistry,supramolecular chemistry,structure directing agents,template effect,aggregation,microporous materials,zeolite,fluorine
Self-Assembly, Structures and Interactions of Cell Specific Cytoskeleton (IF INTERACTIONS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-08-01
End date: 2015-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Cell specificity plays a critical role in the complexity high-order organism can achieve. The cascade of signals and events leading embryonic stem-cells to differentiate has been a major research topic in the last century. During differentiation, cell-specific proteins are expressed in order to accommodate the necessary specific functions. Among other cell/tissue specific modulations, the cytoskeleton is altered during differentiation and at different developmental stages of a specific cell type. This is presumably to account for the constantly-changing mechanical strains and stresses, as well as interactions with the environment, intracellular transport and cell motility. We propose to study a class of cytoskeleton proteins, named intermediate filaments, which are expressed at various developmental stages and cell/tissue types of neuro-muscular origin. Interdisciplinary studies will include protein purification, biochemical characterization, high-resolution microscopy, as well as structural studies in hydrated state using small-angle x-ray scattering. Combining these multiple techniques, we aim to model and reveal how minor molecular differences between proteins from the intermediate filament family are translated into supramolecular forces that, in turn, alter the cytoskeleton elastic and mechanical properties.

Keywords: biophysics,molecular biophysics,small angle x-ray scattering,soft matter and polymer physics,nanosystems
MOLECULAR MECHANISMS OF AUTOPHAGY REGULATION IN TUBERCULOSIS (AUTOPHAGTUBERCULOSIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-08-01
End date: 2015-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Mycobacterium tuberculosis (M.tb), etiologic agent of tuberculosis (TB), is still the leading cause of mortality by single bacterial infection worldwide. Annually, these air-borne bacilli kill almost 2 million people around the globe. M.tb is an extremely successful pathogen that have developed several strategies to neutralize the host immune defenses. One of significance is the block of phagosome maturation which results in survival and replication of M.tb inside macrophages. Autophagy is a cellular lysosomal degradative process which plays a fundamental role in immune responses to M.tb infection. Indeed, multiple reports show that extracellular inducers of autophagy promote phagosome maturation and killing of M.tb by macrophages. Furthermore, autophagy enhances BCG vaccine efficiency and antigen presentation. Although, M.tb succumbs to induced-autophagy, a recent study indicates that virulent M.tb can also modulate basal autophagy to survive intracellularly. Despite important progresses made in the research field of autophagy and mycobacterial infection, how M.tb regulates autophagy and its role in virulence remains largely unknown. To gain further insights into M.tb-autophagy interplay, we propose to decipherer the molecular mechanisms involved in autophagy regulation by M.tb using original, interdisciplinary and complementary approaches. We will (1) examine the correlation between virulence, pathogenicity of mycobacteria and autophagy modulation in human macrophages; (2) determine autophagy signaling pathways regulated by M.tb; (3) identify new M.tb factors that modulate autophagy. This project proposal will expand our understanding of the intricate relationship between M.tb and autophagy and its role in virulence which should help in the future design of innovative therapeutics for the fight against TB. Moreover, manipulating host autophagy might be one significant alternative for elimination of multi- and extensively-drug-resistant M.tb strains (M/XDR-TB).

Keywords: infection,mycobacterium tuberculosis,macrophages,autophagy,virulence,mutants,gene expression,killing,knockdown,lysosome,phagosome,pathogen,cell biology,biochemistry,autophagosome,disease
Novel therapeutic agents to improve bone quality during fracture repair (FRACQUAL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Supporting this application will enhance the changes for a well-known Swedish biomechanics researcher to relocate to Lund University and suceed with her long term goal to establish her research activities in Sweden. The proposal includes the use of highly advanced technology (engineering and physics) to evaluate novel treatments for bone fractures (orthopedics). Hence, it is truely multidisciplinary and requires the involvement of engineers, physicists, biologists and orthopedic surgeons within the collaborating environments. Fracture repair is a complex process, where about 5-10% of all fractures lead to complications. Complications are especially high in elderly patients with osteoporosis, where more effective treatment options are needed. This project evaluates the effect of newly developed potent bone modulating drugs during fracture repair in osteoporotic animals. Two animal models have been developed and are in use; the bone chamber and the open fracture healing model in rats. The evaluation methods involve highly modern biophysical evaluation techniques in order to determine and evaluate the quality of the newly formed tissue, to assess the treatments clinical potential. Hence, the project applies newly developed technology to study fracture repair and evaluate bone quality, including vascularization (in vivo microCT), composition (Synchrotron FTIR) and structure (Synchrotron SAXS), of the newly formed tissue. A successful outcome would result in enhanced quality of life for many patients. Lund University has long experience in developing novel biological treatments of fracture repair, and excellent technical experimental facilities, including MAX-lab synchrotron facilities, Biomedical Imaging center and Center for Biomechanics at Lund University. Hence, the match between the fellow, the project and the location is excellent.

Keywords: biomedical engineering,biomedical materials,orthopaedics,biomechanics
Dissecting the role of BRCA2 in the DNA damage response and exploiting its parts for anticancer therapy. (DISSECTING BRCA2)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-11-01
End date: 2015-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Mutations in the tumor suppressor gene, BRCA2, cause susceptibility to breast and ovarian cancer. BRCA2 protein is required for homologous recombinational DNA repair (HRR), the predominant mechanism employed by cells to accurately repair DNA double-stranded breaks (DSBs). In humans, the central player of the HRR process is RAD51; it catalyzes the DNA strand exchange that results in the repaired DNA. Through its interaction with RAD51, BRCA2 controls RAD51 function by locating it to the DSBs. Thus, defects in BRCA2 lead to genomic instability, a hallmark of tumorigenesis. During my postdoc, I have revealed important aspects of BRCA2 protein, the regulatory function of the BRC repeats of BRCA2 on RAD51 DNA binding selectivity as well as contribute to the first biochemical characterization of the full-length BRCA2 protein. In an interdisciplinary approach and, as an independent researcher, my main goals are to: 1) Reveal new roles of BRCA2 by mapping the interactions with other proteins: For example, recently a DMC1 interacting site on BRCA2 has been reported involving BRCA2 in meiotic recombination. 2) Better understand the HRR process: Evidences from the BRCA2 homologue in fungus point to another DNA binding site in BRCA2; finding this region in the human protein may decipher important aspects of the regulation of HRR that remain elusive. 3) Exploit regions of the protein as a therapeutic tool for tumor treatment. We will use peptides derived from BRCA2 protein that are involved in interactions with key proteins in the HRR pathway to block this pathway in tumors cells. 4) Develop new strategies to carry these peptides to the targeted tumor cells. The combination of basic science (aims 1, 2) and applied science (aims 3, 4) approaches proposed here provides a framework to understand the connection between different DNA damage response mechanisms that in turn, will lead to develop new anticancer therapies.

Keywords: functional biology,applied biology,human biology,gene therapy,structural biology
The Dialectic of Tradition and the Transformation of Theological Knowledge in Modern Jewish Writing (TRADITION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-08-01
End date: 2015-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The project deals with transformations of theological knowledge in 20th century Jewish literature and thought. It looks at various cases in which religious traditions have been translated, interpreted and implied in new contexts of poetics and political thinking. The project, however, studies not only how traditions shape the world of modern Judaism, but also looks at modernist interpretations as creating new experiences of tradition. We are thus dealing with the “dialectic of tradition”– the process through which tradition itself gain new meanings. The project looks at tradition as a process of “delivery,” which also implies opening and renewal. In the modernist frames of Jewish literature, theological knowledge is not eliminated, but rather gains new and different forms of expression. The project should lead to a better understanding of tradition beyond the familiar binary thinking about religiosity and secularism, myth and science, faith and skepticism. Most of the project’s case studies deal with German-Jewish and Hebrew cultures in the 20th century. The methods to be used are multidisciplinary and are based on literary theory and criticism, intellectual and cultural history, rabbinical studies and Jewish philosophy. The project will focus on five major issues: 1. New Hebrew and its theological challenges in the era of secularization. 2. The relationships between poetry and prayer; the translations of the liturgical tradition (the Hebrew piut) and its transformation into new textures of literary and philosophical representation. 3. The figure of the angel and its new, ambiguous appearance in modern literature and thought. 4. The story of the Akeda (the binding of Isaac), its exegesis, and its implications for modern literary criticism. 5. The idea of messianism and its transformations into new poetical textures.

Keywords: humanities
Modulation of AMPA receptor properties by auxiliary subunits. (MOAMAUX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory synaptic transmission in the brain. The regulation of certain AMPARs (calcium-permeable; CP-AMPARs) is relevant in synaptic plasticity, neuronal development and certain neurological diseases. AMPARs are regulated by transmembrane AMPA regulatory proteins (γ-2, -3, -4, -8; TARPs), which affect the trafficking and also important biophysical properties of AMPARs. Among them, we have recently demonstrated that TARPs increase single-channel conductance and attenuate block by intracellular polyamines of CP-AMPARs (Soto et al., 2007). However, the mechanisms involved in those changes are yet to be determined. On the other hand, new AMPARs auxiliary subunits have been recently discovered, such as γ-5, γ-7 or CNIHs raising interesting questions regarding the role of these proteins in AMPARs function. For example, how do TARPs modify the block of AMPARs by polyamines? How do the new auxiliary subunits affect some biophysical properties of AMPARs? Do TARPs or CNIHs modulate AMPARs in periferic nervous system (motorneurons or Schwann cells)? Therefore, the aim of the proposed research project is to further our understanding of the roles played by AMPARs auxiliary subunits (TARPs and CNIHs). We will address the following issues: 1) Using patch-clamp techniques we will investigate AMPARs modulation by auxiliary subunits and the molecular mechanisms involved in that modulation. 2) With the patch-clamp technique in either expression systems or neuronal cultures, we will study AMPARs auxiliary subunits focusing on the new recently discovered ones. We will take advantage of pharmacological and molecular tools (site-directed mutagenesis and siRNA) combined with the patch-clamp records. 3) The role of auxiliary subunits will be investigated in motor neurons and Schwann cells. We anticipate that the results will shed new light on the AMPAR field that will be invaluable in future improvements for certain CNS conditions.

Keywords: neurosciences,ampa receptors,auxiliary subunits,tarps,cnihs,polyamines,patch-clamp,sirna,site-directed mutagenesis,expression systems,neuronal cultures,motorneuron,schwann cell.