Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Trustworthy and Inclusive MLOps (Machine Learning Operations) made in Europe (TIME)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Italy
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-06-01
End date: 2022-11-30
Duration (months): 6.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Trustworthy and Inclusive MLOps made in Europe (TIME) aims at accelerating the realisation of the strategic ambition of Clearbox AI a deeptech Italian startup, led by a woman leader, Dr. Shalini Kurapati. Our current product, the AI Control Room enables companies to harness the power of AI following the Trustworthy AI principles efficiently and robustly. The AI control room is both a cloud-based and on-premises software platform built on a patented implementation of generative models derived from 10 years of Research and Development. It implements the various principles of trustworthy AI such as data assessment, technical robustness check, model validation, monitoring and reproducibility in a viable and easily usable technical environment. The objective of Clearbox AI is to validate a sustainable business model while creating a positive and lasting impact on society through AI. Through this call the main activities we plan to implement towards this objective are to: 1. Implement the bias and discrimination assessment and mitigation module within our product offering and release it open source 2. Accelerate Communication and dissemination of the value-based propositions of trust, bias mitigation, and inclusion. Our ambition beyond our commercial success and positive social impact is to continue to challenge the technology competitiveness gap in AI in Europe (Enterprise/civilian AI adoption is behind US, China, and Israel) and global women leadership gap (only 8% of AI leadership roles are held by women). The Women tech EU call can help us accelerate our path to create this impact and to support Clearbox AI, and its woman leader in competing with larger players on the platform of global EU leadership in Trustworthy AI.

Keywords: trustworthy ai,mlops,fairness,bias mitigation,inclusion in ai,open source,data centric ai,machine learning,ai model management,ai adoption
Phase-matched nonlInear Optics iN layEred sEmiconductoRs (PIONEER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2026-02-28
Duration (months): 36.0
Total project cost (EUR): 265099.2
EU funding (EUR): 265099.2
Participants: 2
Project status: SIGNED

Light is one of the most powerful tools in our hands to study the world around us. Lasers have indeed revolutionized our daily life. Since they only work at a few fixed wavelengths, it is crucial to convert their wavelength into the required one. Nonlinear optics provides essential tools to this end. For instance, second harmonic generation is a nonlinear process in which an intense input field at frequency ω generates a new field at the second harmonic frequency 2ω. The maximum efficiency of the nonlinear process is achieved by minimising the wave vector mismatch ∆k, i.e. the difference of the input wave vector at ω and the wave vector of the second harmonic at 2ω, achieving the so-called phase-matching condition (∆k=0). Birefringent phase-matching (BPM) can be obtained in anisotropic nonlinear crystals with moderate nonlinearities (few pm/V). Alternatively, quasi-phase-matching (QPM) makes use of periodically-poled nonlinear crystals with larger nonlinearities (10-20 pm/V). Typical crystals for BPM and QPM have a large efficiency but macroscopic thickness, i.e. millimeter/centimeters, and do not easily lend themselves to on-chip integration. PIONEER aims at revolutionising nonlinear optics at the nanoscale, achieving birefringent and quasi phase-matching in engineered vertical stacks of layered semiconductors, like non-centrosymmetric transition metal dichalcogenides (3R-TMDs), which possess huge nonlinearities (100-1000 pm/V) and promise to achieve the same efficiencies of bulk nonlinear crystals within micron-thicknesses. The goal of PIONEER is the development of ultra-compact on-chip integrable nonlinear devices, like entangled photon sources, nano-lasers and waveguides based on 3R-TMDs, exceeding the performances of state-of-the-art photonic resonators and nonlinear waveguides. PIONEER will initiate the field of phase-matched nonlinear optics with layered semiconductors and will trigger the next revolution of integrated nonlinear optical devices.

Keywords: nonlinear optics,second harmonic generation,phase matching,quasi phase matching,coherence length,transition metal dichalcogenides,quantum optics,entangled photons,lasing,integrated optics
Bringing affordable population-level Multi Cancer Early Detection Screening to Europe powered by chemistry and AI (Enlighten)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2485000.0
EU funding (EUR): 2485000.0
Participants: 1
Project status: SIGNED

1 in 3 Europeans will become cancer patients within a lifetime. Proteotype is a MedTech company aiming to Light the WayTM for cancer patients by detecting cancer earlier, when prognosis and treatment options are better. Reducing the cancer burden is only achievable through the implementation of population-wide screening programs that effectively detect cancer at early stages. Despite efforts to implement screening programmes, 50% of cancers are detected at late stages, and 70% of cancer deaths occur from cancers without available screening. To address this problem, several companies have been developing multicancer detection platforms, fostering a burgeoning market estimated to achieve up to €70 billion by 2035. Proteotype has developed EnlightenTM, a cutting-edge Multi-Cancer Early Detection (MCED) test that leverages the patient’s host response to tumours (which is high in the early stages of cancer) through the measurement and analysis of innovative biomarkers (Protein Cross Sections - PCS) using fluorescence-generating compounds and AI. The EIC-A support will be crucial for EnlightenTM development and progression of its TRL level. The Grant Component will be critical for conducting a pivotal clinical trial aimed at maturing our product (extending the analysis to 10 different solid tumours, ensuring robust test sensitivity, and improving the accuracy of tissue-of-origin prediction). Furthermore, the Investment Component will fund a Performance Evaluation Trial. This will assess the performance of our test in its intended use environment, achieving EnlightenTM regulatory approval in the EU, UK, and USA within 3 years, and strengthening its commercialization and adoption as a population-wide cancer screening tool. Overall, the launch of EnlightenTM will solidify the EU’s position at the forefront of global oncology research and provide Proteotype with approximately €4.8 billion in cumulative revenues by 2035, 5 years after market launch.

Keywords: multi cancer early detection mced,early stage cancer,liquid biopsy,biorthogonal chemistry,machine learning
Uncovering the Defensome genetic toolkit of marine embryos in the context of climate change (OikoDefensome)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: SIGNED

Intensification of the frequency and severity of harmful algae blooms (HABs) has recently increased due to climate change and global warming, affecting environment, human health as well as local economies based on fishing and/or recreational activities. Some diatom species (representing half of the primary production of the oceans) synthesize biotoxic compounds derived from secondary metabolites known as oxylipins, which are highly produced during HABs upon cell damage. Several studies have reported that Polyunsaturated aldehydes (PUAs), among the most studied oxylipins, have negative effects on many marine organisms, reporting impairment of growth, reproduction, cell homeostasis and detoxification. However, the genetic mechanisms that regulate these physiological responses are still unknown. It has been proposed that some organisms could have a set of conserved genes that will be activated upon PUAs exposure, the so call ‘Defensome’, but few members had been described. The larvacean Oikopleura dioica is one of the many organisms affected by PUAs. In addition of being among the most abundant components of the mesozooplankton, O. dioica is an “evolutionary-knockout” for many signalling pathways being a perfect candidate to study biological adaptations by gene loss. Using O. dioica as animal model we aim to identify conserved Defensome genes shared among marine animals and to study the developmental pathways affected by biotoxins. To achieve this goal, we will combine transcriptomics (RNASeq), chromatin accessibility (ATAC-Seq) and gene interference approaches (RNAi, DNAi, Cas9-CRISPR). The results of this project will be key for understanding the genetic adaptive response of marine embryos to the biotoxic impact of HABs on marine environments worldwide. Moreover, the discovery of a conserved set of Defensome genes across different groups of marine animals, could provide a useful set of pan-markers of environmental stress for be applied in many different species.
Probing the quantum nature of gravity at all scales (ProbeQG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1987603.0
EU funding (EUR): 1987603.0
Participants: 1
Project status: SIGNED

To understand the quantum structure of spacetime, we must confront proposed theories of quantum gravity with experimental data. This is a challenge, because quantum-gravity effects are generally assumed to manifest at the Planck length, which lies far beyond current experimental reach. I challenge this assumption by probing quantum gravity at different scales. To achieve this, I propose to use lever arms that translate predictions of quantum gravity at the Planck scale into predictions at larger distances, where we can compare them to experimental data. I have identified such lever arms in particle physics, black holes and cosmology. The proposal’s first testing ground for quantum gravity is particle physics, where the scale dependence of couplings is a lever arm that translates Planck-scale predictions into testable predictions at larger distances. Using this lever arm, I will predict the values of couplings in the Standard Model and models of dark matter. The second testing ground is black holes, where the spin can act as a lever arm that translates Planckian physics into horizon-scale effects. To use this lever arm, I will derive spinning black-hole spacetimes and explore their image features. The third testing ground is late-time cosmology, where the dark energy is a lever arm that translates a microscopic interplay of scalar fields with gravity into an accelerated expansion of the universe. To use this lever arm, I will predict the properties of dark energy. The proposal’s main objective – to confront quantum gravity theory with observational data – will thus be achieved by forging new connections between quantum gravity and other research fields. These novel connections also provide a fresh perspective on long-standing questions in these other fields, for example on the nature of dark matter and dark energy. To demonstrate the power of these lever arms, I will work in the framework of asymptotic safety, a compelling framework for a quantum theory of gravity.

Keywords: quantum gravity phenomenology asymptotically safe quantum gravity interplay of quantum gravity with matter quantum effects in black holes
VALIDATING AI IN CLASSIFYING CANCER IN REAL-TIME SURGERY (CLASSICA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Ireland,France,Netherlands,Denmark,Italy,Belgium,Slovenia,Austria,United States
Call: Clinical validation of artificial intelligence (AI) solutions for treatment and care (HORIZON-HLTH-2021-DISEASE-04, 2021)
Start date: 2022-05-01
End date: 2026-04-30
Duration (months): 48.0
Total project cost (EUR): 5978718.74
EU funding (EUR): 5978716.0
Participants: 13
Project status: SIGNED

Building on breakthrough research in the AI analysis of fluorescence and perfusion in cancer tissues, this project clinically validates the use of AI-driven imaging and decision support in real-time cancer surgery. Cancer and healthy tissue have radically different local blood perfusion patterns. This perfusion can be captured using near-infrared video after systemic fluorophore (indocyanine green) injection. Analysis of the video can digitally identify regions of cancer by tracking the perfusion over the initial seconds after dye administration by comparing the fluorescence signal in these areas with those in adjacent normal tissue within the same endolaparoscopic field of view. Application of AI methods (including computer vision and machine learning techniques) has enabled this differential classification to occur in real time so that better, individualised surgical decisions can be taken during an operation. In this project, we build up our existing AI solution research prototype into an operating room-standard surgical tool and validate its performance, reliability, usability and acceptance in five leading cancer surgery centres across Europe (500 patients). The validation studies address (a) generalisability across clinics; (b) biopsy and tumour identification; and (c) optimised resection of large (>3cm) rectal polyps, a key area of current surgical practice where the biggest clinical challenge ensuring accurate patient selection for curative therapy. Training and education, communication and dissemination will be delivered by IRCAD, Europe's leading surgical education organisation. Legal, regulatory and liability research (co-led by UCPH CeBIL Centre and PSU) and usability and acceptance research (led by surgical professional organisation EAES) will identify and address all obstacles to widespread use of this technology in particular, and of real-time AI in the operating-room in general. Draft clinical guidelines will be created for future EAES adoption.

Keywords: dynamic fluorescence video analysis artificial intelligence real time ai surgical support
Mechanisms of gas-driven mineral weathering in a changing climate (DryCO2)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 1499176.0
EU funding (EUR): 1499176.0
Participants: 1
Project status: CLOSED

Chemical reactions in the unsaturated zone in Earth's shallow subsurface, where pores are filled with a mixture of fluid and gas, support life on our planet and have a profound influence on the global carbon cycle and climate. Gas-driven mineral weathering reactions not only provide nutrients essential to life but serve to regulate atmospheric CO2 concentrations and climate, and are facilitated in the unsaturated zone where reactive gases like CO2 and O2 are readily transported. Earth's climate has experienced major fluctuations over its history, and is currently changing rapidly due to human activities. Climate change impacts the size and water content of the unsaturated zone, and therefore the rates of mineral weathering. At present, prediction of the impacts of changes in water saturation, CO2 concentration, and temperature on mineral weathering rates is hindered by an incomplete understanding of the controls on mineral weathering in the unsaturated zone. DryCO2 will elucidate the physical and chemical controls on gas-driven mineral weathering in the unsaturated zone to evaluate climate evolution over Earth's history, to optimize engineered CO2 removal for climate change mitigation, and to forecast the impact of future anthropogenic climate change on the mineral weathering reactions that store CO2 and release nutrients. DryCO2 will comprise five work packages, and combines experimental studies at multiple scales in the laboratory and field, analysis of key field samples, and multi-scale reactive transport modelling. This multi-scale, multi-tool approach will allow DryCO2 to quantify the effects of CO2 concentration and changes in water availability on mineral weathering reactions from the mineral surface to the global scale in a comprehensive fashion.

Keywords: co2 storage carbon cycle mineral weathering kinetics carbon mineralization reactive transport modelling experimental geochemistry unsaturated zone critical zone
Time-Delay PhotoIonization of Core-Orbitals in the Molecular Frame (TD-PICO-MF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-15
End date: 2025-03-14
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

The recent development of broadband coherent extreme ultraviolet sources makes it possible to measure dynamics with attosecond resolution (1 attosecond = 10-18 s). This time scale is associated with the electron dynamics and more particularly to the electronic correlation in various systems, from atoms and molecules to solids. Generating and controlling processes on this time scale then gives the opportunity to develop new promising applications in chemistry and biology that can have high impact in society. TD-PICO-MF aims at studying electronic correlation through the measurement of the photoemission delay of core-orbital electrons in a laser-controlled molecular system. For this purpose, TD-PICO-MF brings together advanced technologies from the attosecond interferometry field and laser-induced alignment field, in order to resolve both spatially and temporally the photoemission process. In particular, the research project proposes to study, as a prototype, the photoemission from the 4d core-orbitals of the iodine atom in iodine monochloride (ICl) molecules in gas phase. The measurements will be realized during different laser controlled configurations of the molecular system e.g., during its alignment, orientation and dissociation. The expected impact is to gain a global picture of the influence of the molecular cationic potential during a chemical reaction and to evidence the role of electronic correlation through the measurement of 3D-scattering phase maps in the molecular frame. TD-PICO-MF will utilize existing, and forge new, international collaborations between experiment, theory and academia in order to tackle this complex problematic. The results of our work will be made globally available and presented to the general public. The post doctoral fellow will bring to the host his expertise on laser control of molecular systems and will be trained to the attosecond science and technologies, enlarging his scientific experience and employability.

Keywords: attosecond ultrafast strong field molecular physics high harmonic generation rabbit laser induced alignment time resolved photoemission velocity map imaging core orbital ionization
Towards full implementation of the KM3NeT Research Infrastructure (KM3NET-INFRADEV2)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: France,Germany,Italy,Greece,Spain,Netherlands
Call: Consolidation of the research infrastructure landscape – Individual support for ESFRI projects (HORIZON-INFRA-2021-DEV-02, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 1498537.5
EU funding (EUR): 1498537.5
Participants: 6
Project status: SIGNED

KM3NeT is a large Research Infrastructure comprising a network of deep-sea neutrino telescopes in the Mediterranean Sea with user ports for earth and sea sciences instrumentation. The main science objectives, a description of the technology and a summary of the costs are presented in the KM3NeT Letter of Intent. Following the appearance of KM3NeT on the ESFRI roadmap 2016 and in line with the recommendations of the Assessment Expert Group this proposal addresses the Coordination and Support Actions (CSA) to prepare a legal entity for KM3NeT and establish open access to the RI, thereby providing a sustainable solution for the operation of the Research Infrastructure during ten (or more) years. During the EU-funded Design Study (2006 - 2010) and Preparatory Phase (2008-2012), a cost-effective technology was developed, deep-sea sites were selected and the Collaboration was formed. This proposal constitutes a second INFRADEV CSA dedicated to KM3NeT. The project will be carried out within the context of the current KM3NeT Collaboration which already has a provisional implementation of the management and governance of the Research Infrastructure in place. The resources requested will be complemented by the Collaboration.

Keywords: neutrino telescope,deep sea research infrastructure,legal entity,open science,neutrino astronomy,neutrino physics