Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mechanisms of protein SUMOylation and its functional consequences (SUMOwriteNread)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1493515.0
EU funding (EUR): 1493515.0
Participants: 1
Project status: SIGNED

Protein post-translational modification with small ubiquitin-like modifiers (SUMO1, -2, and -3), also known as SUMOylation, targets a third of human proteins, is essential for organisms from yeast to humans, and has strong links to cancer and neurodegeneration. Like ubiquitylation, to which it is related, SUMOylation typically depends on the action of enzymes called E3 ligases, which help determine substrate specificity and the exact signal that is produced. However, while for ubiquitylation several hundred E3s are known, no more than two dozen SUMO-specific E3s have been described and only four characterised structurally in a way that reveals their mechanism. Intriguingly, the SUMO E3 ligase activity keeps being detected in proteins that are unrelated to each other and sometimes can be mapped to apparent disordered regions. In the first part of this project, I will explore the poorly charted territory of SUMO writing by elucidating the structure and mechanism of some known SUMO E3 ligases for which the mechanism is unclear. This analysis will serve as a stepping stone to proposing computational, chemical biology, and structural biology approaches to identifying and characterising new SUMO E3s. In the second part, I will investigate downstream consequences of SUMOylation. Following attachment to a protein substrate, SUMOylation is thought to function as a “molecular glue” by promoting formation of protein complexes with specific SUMO “readers”, but detailed structural and biochemical information is lacking for any of such putative assemblies. To address this topic, I will develop strategies to identify and characterise SUMO-dependent complexes. The new tools, approaches, and knowledge about SUMO writing and reading will be broadly applicable to pathways regulated by SUMOylation, allowing their understanding in molecular and mechanistic terms. The study will also explore general concepts in protein evolution and evolutionary emergence of signalling systems.

Keywords: protein post translational modification,ptm,ubiquitin like modification,sumoylation,sumo,e3 ligase,sumo e3 ligase,parp1,activity based probe,protein structure and function,protein evolution,click chemistry,x ray crystallography,cryo electron microscopy,structural modelling
Networking for excellence in the development of innovative, consumer-oriented horticultural food products using the Living Lab approach (HortiFoodTrends)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Environment and Geosciences
Countries involved: Poland,Denmark,France
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 1496870.32
EU funding (EUR): 1496870.32
Participants: 4
Project status: SIGNED

HORTIFOODTRENDS is a project under which Instytut Ogrodnictwa – Państwowy Instytut Badawczy (InHort) will establish and implement into its practice a long-lasting, interdisciplinary collaboration network with high profile European partners: Københavns Universitet (UCPH), Association Groupe ESA (GROUPE ESA) and Centre de recherche de l'Institut Lyfe (LYFE), in the field of novel food product development, considering the needs of the end-user (consumers and food processing sector), with an approach defined as the Living Lab formula. In accordance with the InHort competence, traditionally strongly linked with horticultural producers and the postharvest management of horticultural commodities, the project effort will focus on creating health-promoting novel foods by using emerging processing techniques dedicated to fruit and vegetable preservation. Obtaining appropriate competences to carry out work in the consumer-oriented formula, and in particular using the Living Lab approach, will provide InHort with a unique tool to enhance the knowledge transfer into the agri-food sector. Cooperation of food technologists (technological knowledge aimed at maintaining the health-promoting properties of processed raw materials) with specialists in the field of consumer sciences (knowledge of communicating with consumers) contrasting with consumers’ needs and preferences as well as market and economic conditions articulated by entrepreneurs (work in the Living Lab formula ), is expected to substantially increase the likelihood of delivering innovative nutritionally and sensory valuable products to the HortiFood market. Thus, a conscious consumer, in line with the idea of the EU strategy "From farm to Fork", will have better access to high-quality food products produced using current, environmentally friendly modern processing technologies. Besides, within HORTIFOODTRENDS activity strengthening research management capacities and administrative skills are foreseen.

Keywords: novel food product,emerging technology,sensory analysis,perception tracing,food design thinking,knowledge transfer
Unravelling White Matter Biological Heterogeneity for the Prediction of AD (WHY-AD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 2
Project status: SIGNED

White matter (WM) is being increasingly studied in Alzheimer’s disease (AD) as a possible key pathological driver. In-vivo, WM health can be measured through several metrics derived from diffusion weighted imaging (DWI). While these metrics provide information about the WM micro- and macro-structural alterations, the biological processes determining such changes is often unclear. Characterizing these biological pathways is crucial for a more refined use of MRI in the clinics and for building accurate disease models for individualized prediction. In this work, we will use several cohorts covering the AD spectrum with both available MRI and biological data (genetics, proteomics). We will first perform a characterization of the biological pathways that provoke WM dysfunction in different stages of AD. Subsequently, we will use this information to build data-driven models of disease progression and spreading. Finally, we will test the applicability of these models in data from memory clinics.

Keywords: multi omics,white matter,diffusion imaging,biomarkers,disease modeling
Advancing SOLid-state battery development and production to driVE the future of electromobility (SOLVE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Spain,France,Italy,Slovenia,Finland,Germany,Austria,Switzerland
Call: Advanced materials and cells development enabling large-scale production of Gen4 solid-state batteries for mobility applications (Batt4EU Partnership) (HORIZON-CL5-2023-D2-02, 2023)
Start date: 2024-06-01
End date: 2028-05-31
Duration (months): 48.0
Total project cost (EUR): 8902038.75
EU funding (EUR): 7623420.99
Participants: 16
Project status: SIGNED

Solid-state batteries (SSB) offer a promising opportunity for the EU to become an early player and enhance its position in the global battery market. Supported by a consortium comprised of key industry and academic players in the battery field, SOLVE aims to capitalize on the extensive R&D base and contribute to the scaling-up efforts required for SSB Gen4b mass production. To this end, SOLVE will address the most significant barriers hindering sector growth by demonstrating innovations across the main stages of the value chain, optimizing active and inactive materials, and associated processing techniques under industrially relevant conditions (TRL>=6). This will help achieve high-performing, cost-effective, and safe- and sustainable-by-design 20 Ah SSB prototypes and a proof-of-concept 0.25 kWh module based on: (i) thin, defect-free hybrid solid polymer based electrolytes (<=30 μm, >0.5 mS/cm @25-40ºC, >4.7 V); (ii) high loading solid state cathodes (>4.0 mAh/cm2) based on 4V-class cathode active materials (>200 mAh/g), and (iii) ultra-thin Li metal anodes (including cutting-edge lithophilic current collectors for the development of zero Li excess SSB) (<10 µm, >3.000 mAh/g), all of them produced through easily scalable and sustainable R2R processes. This entire process will be reinforced by the implementation and adaptation of predeveloped digital tools and models to support and accelerate the SSB design, as well as the incorporation of imperative sustainability criteria to promote efficient resource utilization through eco-design principles and the development of innovative recycling processes. Finally, a robust dissemination, communication and exploitation strategy, including the development of tailor-made training activities and business models, will be established to propel SOLVE’s post-project commercialization and future market success, ultimately contributing to the decarbonization of the transport sector and the widespread adoption of electromobility.

Keywords: solid state battery,lithium anode,lithiophilic current collector,hybrid solid electrolyte,battery modelling,safe by design battery,electromobility,gen4b
Community-driven Farming for the Atlantic and Arctic sea basins through REgeneRative aquaculture (C-FAARER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Coordination and support actions
Countries involved: Ireland,Netherlands,Norway
Call: Towards local community-driven business models: regenerative ocean farming (HORIZON-MISS-2022-OCEAN-01, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 1000002.5
EU funding (EUR): 1000002.5
Participants: 6
Project status: SIGNED

To restore and protect ocean ecosystems within a sustainable blue economy, in line with the objectives of the Mission ‘Restore Our Ocean and Waters by 2030’, we urgently need new business models for regenerative aquaculture, informed by best scientific evidence on environmental impacts and developed in partnership with societal stakeholders. To encourage adoption, such practices must be technically, operationally, and economically viable for ocean farmers, with clear benefits to ecosystem services, community resilience, market potential and job creation. C-FAARER will deliver a roadmap and guidance, co-designed with stakeholders, to support ocean farmers in the Atlantic and Arctic Sea basin to develop community-driven business models for regenerative ocean farming and policymakers to take enabling actions. C-FAARER builds on prior EU projects, reviewing evidence on socio-economic and environmental impacts and successful community business models to establish a robust case for adoption. Working with ocean farmers and coastal communities at sites in Norway and Ireland, we will analyse technical, operational, economic, environmental, and social needs and create guidance on developing site-specific community-led business plans. We will co-design feasibility reports and evidence-based business plans with members of the Norwegian Seaweed Association cluster of 80+ ocean farmers, replicate lessons via a new Irish Seaweed Association and ensure long-term sustainability through a new Community of Practice on the established Connecting Nature Enterprise Platform. Policy recommendations will highlight barriers, supports and investments needed from local, national and EU authorities to strengthen and scale regenerative community-led aquaculture in the Atlantic and Arctic Sea basin. Clustering and engagement with Ocean Mission projects and partner networks will identify opportunities to embed community-led business models for regenerative aquaculture in future Mission actions.

Keywords: regional development
The Nuclear Pore Complex: Bridging Membrane Remodelling and Lipid Metabolism (NPC-MEM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2499250.0
EU funding (EUR): 2499250.0
Participants: 1
Project status: SIGNED

The nuclear pore complex (NPC) is a defining component of eukaryotic cells. Its role as a selective transport channel is well-documented, but NPCs also remodel the nuclear envelope, bending and fusing the inner and outer nuclear membranes to form a pore without rupturing the cell nucleus. The underlying mechanism of this process is poorly understood, despite its profound implications for cellular function. My proposal addresses how nuclear pore complexes function as membrane remodelling machines, which remains a fundamental question in eukaryotic biology. Despite its significance, this question has been scarcely explored, primarily due to technical challenges. These include the need for detailed knowledge of NPC protein structure, which has only recently emerged, the lack of tools for NPC membrane biochemistry, and the requirement for a deeper understanding of the inner nuclear membrane (INM), where NPC biogenesis begins during interphase. The process by which NPCs sculpt membrane pores is tied to lipid chemistry, which is the output of lipid metabolism. Therefore, the core strategy of this proposal is to study the nexus between nucleoporins, lipids, and lipid metabolism in an integrated manner, through biochemical reconstitution and system-wide approaches. Using newly developed tools, we will reconstitute and structurally characterize the largest NPC assembly on a membrane to date, revealing how stepwise NPC assembly drives progressive membrane remodelling. This will enable us to reveal the principles of pore membrane formation. Concurrently, we will identify every lipid metabolism enzyme at the INM and use new technology to catalogue all INM lipids. This will provide a foundational reference for nuclear envelope biology and enable us to test how specific lipids impact NPCs and the cell nucleus. This proposal aims to offer pioneering insights into NPC biogenesis and how nuclear lipid metabolism affects NPC function.

Keywords: nuclear pore complex,nuclear envelope,inner nuclear membrane,lipid metabolism
Robotics Knowledge Transfer Lab (ROBO-KNOT)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Hungary,Belgium,Spain,Portugal,Slovenia,Greece,Estonia
Call: ERA Talents (HORIZON-WIDERA-2024-TALENTS-03, 2024)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 2978690.0
EU funding (EUR): 2978690.0
Participants: 12
Project status: SIGNED

The ROBOtics KNOwledge Transfer Lab (ROBO-KNOT) is a cross-sectoral and cross-border mobility initiative designed to accelerate knowledge transfer in the Robotics field. By facilitating secondments of Research and Innovation (R&I) talent between academic and non-academic sectors, this project aims to promote more attractive and sustainable research careers in Widening Countries, in alignment with the European Commission’s ERA Policy Agenda (Action 4). The project will directly involve 24 researchers and 12 R&I support staff from academic institutions in Widening Countries (Greece, Portugal, Slovenia), who will be seconded to organisations in either Widening (Estonia, Greece, Portugal) or non-Widening (Spain) countries. ROBO-KNOT's structured methodology, comprising Pre-secondment, Secondment, and Post-secondment phases, ensures impactful skills development and knowledge exchange. Firstly, talent is carefully selected and matched with opportunities that align with both individual goals and hosting organisations’ strategic needs. Through a modular secondment approach, participants are then immersed in diverse work settings, enhancing their practical knowledge of Robotics technologies’ commercial development. Finally, the Post-secondment phase includes targeted training activities and ongoing support to ensure long-term impact of the action, particularly with regards to the innovation-to-commercialisation pipeline. ROBO-KNOT has developed a tailored Skills Development Framework, in line with the European Commission’s ResearchComp, as well as a Career Advancement Plan, which ensures high impact of the project on secondees’ employability, future career prospects and knowledge sharing capabilities. ROBO-KNOT not only benefits seconded talent individually, but also increases consortium organisations’ R&I support capacity and ability to establish effective cross-sectoral and cross-border collaborations, contributing to a more integrated European innovation ecosystem.

Keywords: knowledge transfer,robotics,randi talent secondment,randi talent skills development,randi support capacity,research commercialisation,entrepreneurial training,cross sectoral collaboration
CIRCULAR ECOLOGICAL ESSENTIAL & CRITICAL RAW MATERIALS (ROTATE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Countries involved: Spain,France,Sweden,Denmark,Portugal,Norway,Belgium,United Kingdom,Finland
Call: Reducing environmental footprint, improving circularity in extractive and processing value chains (IA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 14212290.49
EU funding (EUR): 11432610.0
Participants: 24
Project status: SIGNED

ROTATE's ambition is to tap the full potential of minerals extraction and processing in a sustainable and ecological way, developing the needed technologies and tools for achieving zero emissions and pollution for essential and critical raw materials obtention and ensuring a circular approach by implementing mechanisms for waste valorisation in the context of industrial symbiosis, especially reusing waste as aggregates for the construction sector and also recovering secondary products. ROTATE'S GENERAL OBJECTIVE is to achieve a near zero emissions and pollution obtention of raw materials, providing new tools for the mining industry in its journey to a more sustainable and green mineral extraction. The solutions proposed in the project will allow to improve the cut-off grade while reducing the environmental footprint of the whole process. The pilot demonstrations in mineral deposits with different paragenetic (minerals occurring together in a rock, formed by the same genetic process during the same stage) profiles will ensure the replication of the technologies to a wide variety of mining sites. To ensure EU?s lead on Critical Raw Materials access, the project is structured in three main interconnected PILLARS providing technical solutions and three transversal FLOORS covering cross cutting issues, including clustering and social acceptance. A series of technical Project Results of Pillars [PRP] and Project Results of Floors [PRF] will be delivered within the ROTATE's framework. ROTATE's will deliver specific methods and/or technologies aiming to overcome the reluctance of social agents to the exploitation of CRM deposits thanks to the environmental impact reduction achieved. This will result in an increase of the CRM sites that could be exploited in a future, boosting the access of EU to strategic CRM and enabling the development of the Renewables, e-mobility and Defence & Space sectors.

Keywords: critical raw materials,valorisation,environmental assessment
Next-Generation Epitope Mapping Technology to Unleash the Full Potential of Advanced Monoclonal Antibody Therapies. (Seqitope)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2497950.0
EU funding (EUR): 2497950.0
Participants: 1
Project status: SIGNED

The emergence and evolution of viral variants driven by factors like climate change and global interconnectedness have led to a surge in infectious diseases. Viral variants like Delta and Omicron have showcased higher transmissibility and immune evasion, emphasizing the need for adaptable therapeutic solutions. The economic and social impact of pandemics, as seen in COVID-19, has been devastating, highlighting the importance of effective countermeasures. Monoclonal antibodies (mAbs) offer targeted responses to viral variants, especially when engineered to target conserved epitopes. mAbs play a dual role in prevention and treatment and complement vaccines. Precise epitope mapping is pivotal in mAb development, ensuring accuracy and adaptability to evolving viruses. However, current mapping technologies are expensive and face limitations in handling antigens and offer limited throughput and resolution. Seqitope, pioneered by AAX Biotech, revolutionizes epitope mapping with its exceptional high throughput, precise single amino acid resolution and groundbreaking cost-effectiveness, makes epitope mapping accessible to all budgets. This remarkable high throughput, coupled with minimal material requirements, not only broadens accessibility but also facilitates unprecedented turnaround times, translating into the fastest response to disease outbreaks and enhancing global preparedness. With the epitope mapping market projected to grow significantly, reaching approximately $726 million by 2028 at a CAGR of 16.1%, the EIC Accelerator funding is key to enhancing Seqitope's capabilities. Our aim is to automate and robotize its processes, maximizing our engagement with this expanding market. This expansion will enable Seqitope to significantly enhance the development of monoclonal antibody-based therapies, offering a transformative impact on global healthcare.

Keywords: epitope mapping,monoclonal antibodies,antigen,disease outbreak response,antibody therapeutics,precision medicine,bioinformatics,next generation sequencing,phages,viral variant analysis