Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Assessing the role of climate adaptation on human evolution and its implications for health. (ClimAHealth)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-15
End date: 2025-02-03
Duration (months): 36.0
Total project cost (EUR): 263732.16
EU funding (EUR): 263732.16
Participants: 2
Project status: SIGNED

Climate is a key environmental factor and one of the main selective pressures affecting the survival of organisms, including human beings. Human populations were exposed to a wide range of environmental conditions after the migration Out of Africa, which could have shaped the evolution of traits related to metabolism, like thermoregulation. In this project, we will search for signals of selection caused by climate across the human genome to study climate adaptation in our species. We will assess the existence of recent and ancient events of selection using novel approaches that increase the statistical power respect to previous methods and control for many genomic confounding factors that are usually overlooked. We will combine bootstrapping and machine learning methods to this end. This project will focus on the influence of climate in the evolution of traits related to metabolism (thermoregulation in tissues like brown adipose tissue and skeletal muscle). We will also consider the influence of adaptive introgression from archaic humans (e.g. Neanderthals) that human populations encountered during their migrations. Finally, the evolutionary information generated will be used to inform genetic association studies and medical genetics. We will assess the influence of climate adaptation in current health issues by testing the relationship between climate-selected variants and prevalence of non-infectious chronic diseases. Finally, we will propose and test novel candidate genes for these diseases from genomic regions with high signals of climate selection.

Keywords: positive selection,climate adaptation,adaptive introgression,thermoregulation,brown adipose tissue,skeletal muscle,machine learning,evolutionary medicine,genetic epidemiology,candidate genes
Imaging Voltage Gated Sodium Channels Using Positron Emission Tomography (INSCAPE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-15
End date: 2018-05-14
Duration (months): 36.0
Total project cost (EUR): 239860.8
EU funding (EUR): 239860.8
Participants: 2
Project status: TERMINATED

Voltage gated sodium channels (NaVs) are the primary transmembrane proteins underlying fast electrical communication in neurons of the peripheral and central nervous system (PNS and CNS). Being such an integral part of neuronal signaling, they are implicated in a number of severe diseases that have a major impact on human society. However, drugs and established therapies targeting NaVs are rare due to common off-target effects. Therefore, new NaV-blockers will be developed and used for in vivo imaging using positron emission tomography (PET). For this purpose, novel derivatives of the recently disclosed truncated batrachotoxin (tr-BTX), which represent a completely new type of NaV-blockers, will be synthesized and their ability to block different NaV isoforms (NaV1.1 to 1.8) will be tested using fluorescent assays. The most promising candidates will then be labeled using different positron emitting isotopes such as carbon-11 (11C) and fluorine-18 (18F) exploiting different radioactive half-lifes and metabolic stability. The resulting “hot-tr-BTX” will be subsequently employed in small rodent PET-scans revealing their in vivo pharmacokinetics. This novel and unique tool will provide three major immediate benefits. First, hot-tr-BTX might deliver a general imaging probe for nervous activity in the PNS, and potentially the CNS, by monitoring NaV function in vivo. Secondly, this will allow the investigation of various pain conditions and neurodegenerative diseases and link their pathogenesis to NaV-function. Thirdly, the proposed research might deliver not only new NaV-blockers as potential drug candidates, but will also provide a valuable method facilitating the development of long awaited drugs targeting NaVs for pain therapy, a goal that is currently intensely investigated by numerous European and global pharmaceutical companies.

Keywords: voltage gated sodium channels,pain research,neurodegeneratie diseases,modified natural products,medicinal chemistry,positron emission tomography
Ultrafast spin transport and magnetic order controlled by terahertz electromagnetic pulses (TERAMAG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-07-01
End date: 2022-12-31
Duration (months): 78.0
Total project cost (EUR): 1984375.0
EU funding (EUR): 1719313.0
Participants: 2
Project status: SIGNED

In order to fully exploit the electron spin as a signal carrier in future information processing, spins need to be transported and flipped as fast as possible. Spintronics research aims at implementing these operations by electric fields in circuitry, but has so far been limited to frequencies below ~10 GHz. The much faster complementary femtomagnetism approach employs femtosecond laser pulses (carrier frequency ~400 THz), but is not compatible with microelectronics technology. In the TERAMAG project, I will apply intense terahertz (THz) electromagnetic pulses to solids to realize 1) ultrafast transport of spins and magnons, and 2) ultrafast control over magnetic order. Our strategy relies on extending concepts from the fields of spintronics (electronics) and femtomagnetism (optics) to the elusive THz frequency gap (0.3 to 30 THz), thereby combining the benefits of both worlds. To realize spin operations and open up new pathways to their implementation, it is essential to understand the underlying microscopic processes. THz radiation is an ideal tool for this task as it directly and uniquely interacts with many fundamental modes and couplings of solids at their natural frequencies. For example, by using ultrashort THz pulses, we will obtain unprecedented insights into the energetic structure of spin-orbit coupling of equilibrium and nonequilibrium conduction electrons (e.g. in metals and two-dimensional semiconductors) and into the unexplored but highly relevant interaction of optical phonons with spins, including magnons. Novel measurement schemes (e.g. of the spin Hall effect from ~0.3 to 30 THz) and applications (such as spintronic THz emitters and detectors) will emerge.

Keywords: terahertz,ultrafast
The spectrum of infinite monster groups (SPECMON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

Groups are abstract algebraic structures that mathematically encode the notion of symmetry. Groups are ubiquitous in all areas of mathematics and have applications, for example, to theoretical physics and computer science. Group theory tries to understand particular classes as well as global properties of groups. The theory of infinite monster groups is a crucial part of the theory. It provides examples of infinite groups with exceptional geometric, analytic, and algebraic properties, thus clarifying boundaries of classes of groups and often resolving outstanding open questions. This project aims to develop further methods for constructing and studying infinite monster groups, providing new techniques for producing such groups as well as a deeper understanding of the spectrum of phenomena encountered in the existing theory. The monsters within the scope of this project arise from methods of geometric group theory, which studies finitely generated infinite groups through their actions on geometric structures. The planned work will benefit greatly from the excellent synergies between the ER's geometric viewpoint and Prof. Thom's more analytic viewpoint on infinite groups, a combination which has produced outstanding results in the past. The methods and results developed in this project will lead to significant advances in outstanding open questions. Particular topics addressed by the project are, for example: Diximier's problem on unitarizability of groups (open since 1950), the Kaplansky zero-divisor conjecture (1956), the Baum-Connes conjecture (1982), and the open questions of residual finiteness of hyperbolic groups and of quasi-isometry invariance of acylindrical hyperbolicity. Furthermore, the project will lead to new models of random groups, in particular infinitely presented ones and periodic ones.

Keywords: geometric group theory,analytic group theory,negatively curved groups,small cancellation theory,random groups
Commercialisation of a Novel and Efficient Air Compressor to Improve the Economic Viability of Hydrogen Fuel Cells (FC-eCompressor)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 1167900.0
EU funding (EUR): 817530.0
Participants: 1
Project status: CLOSED

Ongoing environmental and health concerns associated with the use of fossil fuels is driving demand for clean energy sources. For example, countries including China, the UK, Germany, India and France intend to ban new internal combustion vehicles within ~20 years. Battery powered electric vehicles have an important role to play, but they continue to be limited by range and charging time, so there is increasing interest in alternatives such as hydrogen fuel cells. It is predicted that by 2032, over 22 million fuel cells will be in operation. Fuel cells consume stored hydrogen and oxygen (from air) to produce electricity. Heat and water are the only by-products, so the technology is non-polluting at the point of use. However, fuel cells are still relatively expensive and a key way to reduce their cost is to supply air at higher pressure, using a compressor. This increases power output, allowing them to be made smaller and cheaper, but compressors can consume up to 40% of the energy produced by the fuel cell, so their efficiency is critical. Aeristech’s compressors operate much more efficiently, requiring 10-20% less power than competitive products. They are also up to 20% smaller and will operate continuously at high power for 4,000 hours without servicing. These unique advantages are creating enormous commercial interest. Our solution, FC-eCompressor, has been developed to prototype stage (TRL6) and we now need to optimise the technology for production and gain approvals for commercial supply. To achieve this, we must produce sample units that are manufactured using high-volume production techniques, but this is expensive and time-consuming. By overcoming this barrier, we will open-up market opportunities that will create at least 110 new jobs and generate over €65 million in cumulative revenue by 2025.

Keywords: fuel cell,zero emissions,reduction,energy,efficiency,sustainable,compressor,legislation,hydrogen,medical,telecommunications,power generation,transport
Enabling dynamic and Intelligent workflows in the future EuroHPCecosystem (eFlows4HPC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Innovation actions
Partnership: EuroHPC (Art-187)
Countries involved: Spain,Spain,Italy,Germany,Italy,Germany,Germany,Spain,Italy,Italy,Switzerland,Norway,Poland,France,France
Call: HPC and data centric environments and application platforms (H2020-JTI-EuroHPC-2019-1, 2019)
Start date: 2021-01-01
End date: 2024-02-29
Duration (months): 38.0
Total project cost (EUR): 7663216.25
EU funding (EUR): 3576656.13
Participants: 17
Project status: SIGNED

Today, developers lack tools that enable the development of complex workflows involving HPC simulation and modelling with data analytics (DA) and machine learning (ML). TheFlows4HPC aims to deliver a workflow software stack and an additional set of services to enable the integration of HPC simulation and modelling with big data analytics and machine learning in scientific and industrial applications. The software stack will allow to develop innovative adaptive workflows that efficiently use the computing resources and also considering innovative storage solutions. To widen the access to HPC to newcomers, the project will provide HPC Workflows as a Service (HPCWaaS), an environment for sharing, reusing, deploying and executing existing workflows on HPC systems. The workflow technologies, associated machine learning and big data libraries used in the project leverages previous open source European initiatives. Specific optimization tasks for the use of accelerators (FPGAs, GPUs) and the EPI will be performed in the project use cases. To demonstrate the workflow software stack, use cases from three thematic pillars have been selected. Pillar I focuses on the construction of DigitalTwins for the prototyping of complex manufactured objects integrating state-of-the-art adaptive solvers with machine learning and data-mining, contributing to the Industry 4.0 vision. Pillar II develops innovative adaptive workflows for climate and for the study of Tropical Cyclones (TC) in the context of the CMIP6 experiment, including in-situ analytics. Pillar III explores the modelling of natural catastrophes - in particular, earthquakes and their associated tsunamis- shortly after such an event is recorded. Leveraging two existing workflows, the Pillar will work of integrating them with the eFlows4HPC software stack and on producing policies for urgent access to supercomputers. The pillar results will be demonstrated in the target community CoEs to foster adoption and get feedback.

Keywords: scientific and industrial workflows,convergence high performance data analytics,machine learning and high performance computing,distributed and heterogeneous computing,widening hpc usage
Development of new electrode materials and understanding of degradation mechanisms on Solid Oxide High Temperature Electrolysis Cells. (SElySOs)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Greece,Norway,Greece,Greece,France,Czechia
Call: Research in electrolysis for cost effective hydrogen production (H2020-JTI-FCH-2014-1, 2014)
Start date: 2015-11-02
End date: 2020-05-01
Duration (months): 54.0
Total project cost (EUR): 2939655.0
EU funding (EUR): 2939655.0
Participants: 7
Project status: CLOSED

The high temperature Solid Oxide Electrolysis (SOEC) technology has a huge potential for future mass production of hydrogen and shows great dynamics to become commercially competitive against other electrolysis technologies (AEL, PEMEL), which are better established but more expensive and less efficient. On the downside, up to now SOECs are less mature and performance plus durability are currently the most important issues that need to be tackled, while the technological progress is still below the typically accepted standard requirements. Indicatively, the latest studies on State-of-the-Art (SoA) cells with Ni/YSZ and LSM as cathode and anode electrodes, respectively, show that the performance decreases about 2-5% after 1000h of operation for the H2O electrolysis reaction, whereas for the co-electrolysis process the situation is even worse and the technology level is much more behind the commercialization thresholds. In this respect, SElySOs is taking advantage of the opportunity for a 4-years duration project and focuses on understanding of the degradation and lifetime fundamentals on both of the SOEC electrodes, for minimization of their degradation and improvement of their performance and stability mainly under H2O electrolysis and in a certain extent under H2O/CO2 co-electrolysis conditions. Specifically, the main efforts will be addressed on the study of both water and O2 electrodes, where there will be investigation on: (i) Modified SoA Ni-based cermets, (ii) Alternative perovskite-type materials, (iii) Thorough investigation on the O2 electrode, where new more efficient O2 evolving electrodes are going to be examined and proposed. An additional strong point of the proposed project is the development of a theoretical model for description of the performance and degradation of the SOEC fuel electrode. Overall, SElySOs adopts a holistic approach for coping with SOECs degradation and performance, having a strong orientation on the market requirements.

Keywords: high temperature solid oxide electrolysis cells and stacks,h2o electrolysis,h2o plus co2 co electrolysis
Digiteal: European Payment and e-Invoicing platform (Digiteal)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Belgium
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Digiteal is a payment and e-invoices management platform that works in synergy with the Digital Single Market policy. We will support standardization and enable payment in and between all countries of the SEPA zone. Our payment platform gives value to companies within the European Union and to customers by cutting those interoperability transaction costs within the EU and giving EU citizens a complete control of their SEPA mandates. Digiteal aims to reduce the huge dependencies on US online payment services. On the other hand, Digiteal is unique offering a SEPA domiciliation management platform for end-users. Users will be able to manage the bills of all the companies using a unique domiciliation platform. Our innovation is to apply the same principle to e-Invoicing. Our clients are B2C European companies that issue high volume of invoices in paper. We offer an intuitive platform to manage their invoices and reducing the operating costs. Our end users will be able to manage and pay their mandates and invoices for free. During the feasibility assessment in phase I we will study how to develop our SDD payment functionality, study the integrations with European document service providers and detail an International commercialization and Business plan. Also, a Freedom to operate analysis will be performed. Digiteal is a new way of managing invoices and making the SDD payment using disruptive technologies breaking the cross-border limitations within the European countries and our solution will reduce the actual European huge USA dependencies on online payment services. Digiteal will improve the competitiveness of the European companies. We will seize the opportunity brought by the need of modernization of the European unified marketplace, identified by the top priority need of creating a Digital Single Market Strategy within the European Agenda.

Keywords: einvoincing,e invoicing,sdd sct,sepa,payment,digital,single,market,mandates,ebilling,e billing,invoice,bill,qr code,bank
Science for Clean Energy (S4CE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Iceland,Italy,Italy,Germany,Italy,Germany,Germany,Switzerland,Finland,Serbia,Switzerland,Poland,France,France,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Measuring, monitoring and controlling the potential risks of subsurface operations related to CCS and unconventional hydrocarbons (H2020-LCE-2017-RES-CCS-RIA, 2017)
Start date: 2017-09-01
End date: 2020-12-31
Duration (months): 40.0
Total project cost (EUR): 9785730.0
EU funding (EUR): 9785730.0
Participants: 28
Project status: CLOSED

Science4CleanEnergy, S4CE, is a multi-disciplinary consortium, of world-leading academics, research laboratories, SMEs and industries. S4CE will develop a project that includes fundamental studies of fluid transport and reactivity, development of new instruments and methods for the detection and quantification of emissions, micro-seismic events etc., lab and field testing of such new technologies, and the deployment of the successful detection and quantification technologies in sub-surface sites for continuous monitoring of the risks identified by the European Commission. S4CE leverages approximately 500M EUR in existing investments on 4 scientific field sites. S4CE will utilize monitoring data acquired during the project in these field sites on which (a) it will be possible to quantify the environmental impact of sub-surface geo-energy applications; (b) new technologies will be demonstrated; (c) data will be collected during the duration of the project, and potentially after the end of the project. Using reliable data, innovative analytical models and software, S4CE will quantify the likelihood of environmental risks ranging from fugitive emissions, water contamination, induced micro-seismicity, and local impacts. Such quantifications will have enormous positive societal consequences, because environmental risks will be prevented and mitigated. S4CE set up a probabilistic methodology to assess and mitigate both the short and the long term environmental risks connected to the exploration and exploitation of sub-surface geo-energy. S4CE will maintain a transparent dialogue with all stakeholders, including the public at large, the next generation of scientists, academics and industrial operators, including training of young post-graduate students and post-doctoral researchers. S4CE will deliver the independent assessment of the environmental footprint related to geo-energy sub-surface operations, having as primary impact the assistance to to policy making.

Keywords: monitoring environmental impacts,development of technologies,mitigation of short and long term environmental risks,training for geo energy applications,impact on industry and practitioners