Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Beyond double-strand break repair: specific mechanisms of homologous recombination at stressed replication forks. (RecInRep)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Genomic instability is the main driving force of tumourigenesis, as highlighted by the cancer predisposition conferred by mutations in caretaker genes. DNA replication stress has recently received much attention, for its causative role in transformation and as a strategy for cancer therapy. Besides other mechanisms protecting replicating chromosomes from genotoxic stress, transient fork remodelling into four-way junctions (fork reversal) is emerging as a key transaction to assist template repair or to tolerate DNA damage and replication interference. Factors and mechanisms modulating this transaction are just beginning to emerge. The central recombinase RAD51 was recently shown to promote fork reversal, uncovering a fork-specific role for homologous recombination (HR) proteins, beyond their established role in the double-strand break repair. However, the molecular determinants controlling RAD51-mediated fork remodelling are yet unknown. I propose to gain mechanistic insight into the role of RAD51 and other HR proteins in replication stress, using an integrated, multidisciplinary approach, which combines my current biochemical expertise with specialized cell biology and single-molecule techniques available in the host lab. In particular, I will first set up a microscopy-based screen to identify factors that regulate RAD51 recruitment at replication forks upon stress. Then, I will use a combination of single-molecule and cell biology techniques to investigate how these novel RAD51 regulators mediate in vivo RAD51 role in fork protection and remodelling. Finally, I will establish an in vitro system to study biochemically the mechanisms by which RAD51 and the novel identified factors catalyse replication fork remodelling. I believe that this "holistic" approach will be instrumental not only to define the molecular basis of cancers with a HR-defective genetic background, but also to provide the groundwork to develop more effective chemotherapeutic strategies.

Keywords: homologous recombination,genome stability,cancer,high content microscopy based genetic screening,single molecule approaches,replication fork remodelling
Novel Compound Rotary Engine Range Extender for Electric Vehicles (CREEV)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: United Kingdom
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-08-01
End date: 2018-11-30
Duration (months): 28.0
Total project cost (EUR): 990962.5
EU funding (EUR): 693673.75
Participants: 1
Project status: CLOSED

This project seeks to successfully demonstrate and scale up for market readiness, a novel, high efficiency, low emission, compact rotary engine range extender for electric vehicles. Electric vehicles (EV) are emerging as the future of transport as they break the dependence on fossil fuels and offer significant advantages in terms of noise and local air pollution. However, uptake has been poor so far due to range anxiety. As a result, while 44% of drivers consider emissions & environmental friendliness as important factors when buying a car, only 5% would consider buying an electric car due to range concerns. Automotive manufacturers have addressed this issue through the installation of range extender engines. However, existing extenders tend to be too large with poor power density, limiting their use in small commercial and domestic vehicles where space is at a premium.. The clear business opportunity is to provide tier 1 automotive powertrain providers and OEMs with breakthrough innovation in EV range extender technology that significantly improves power density whilst providing high efficiency, low emissions, low noise and low vibration to meet consumer needs. Our solution, CREEV, takes the inherent advantages of rotary (Wankel) type engines for such compact applications and applies patent protected innovations to overcome efficiency and reliability issues to deliver an engine exactly matched to OEM needs. Our breakthrough solution is lab tested/demonstrated. The Phase 1 feasibility study report has already been accepted and this DSI Phase 2 funding application builds on this success. With the market for EVs in Europe growing 1300% in the last 2 years, CREEV offers a market opportunity worth an estimated €79m over 6 years. Our management team has over 100 years’ experience in engine technology and strong links with OEMs and Tier 1 suppliers, ensuring market success.

Keywords: range extender,rotary engine generator,compact,advanced,efficient
Multi-sensory experiences for in-home therapy and entertainment (MOMENTS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Multi-Sensory Environments (MSEs) is a discipline of occupational therapy that helps treat cognitive and sensory deficiencies (in memory, attention, social interaction…) of people with developmental disabilities, physical disabilities, neuro-degenerative diseases and or brain-injuries. These conditions which include autism, dementia, Down syndrome or multiple sclerosis affect over 15% of the population (1,1bn people worldwide). Through a controlled environment for sensory stimulation (that combine sound, vibration, light and multimedia content), MSEs are not only a room or space for therapy but also a real entertainment option for people with sensory or cognitive disabilities who often are not able to enjoy movies, videogames, books… MSEs have become popular at special schools, hospitals, care centres, etc. However, the majority of people with sensory and/or cognitive deficiencies live at home. That means they can only benefit from MSEs during a very limited amount of time. MOMENTS aims to bring the benefits of MSEs directly to the homes of end-users. It plans to do so by launching into the market the first lower-scale (and therefore affordable) MSE product. The in-home product will be supported by a unique intelligent system capable of recommending immersive stimulating experiences that adapt to the physical, cognitive and sensory functions of each user (providing more targeted stimulation and easing operation by family members and/or carers). The overall ambition is not only making MSE therapy available 24/7 but also delivering “inclusive entertainment”. The company behind the project is BJ Adaptaciones, an SME specialised in developing and commercialising technologies for people with disabilities, with a track record in international sales. Through MOMENTS, the company expects to generate an accumulated turnover of 25M€ in 5 years, consolidating their position as a leading innovator in multi-sensory environments in Europe and beyond.

Keywords: multi sensory environments,occupational therapy,disabilities,cognitive function,autism,dementia,multimedia,digital content,snoezelen
Novel mechanisms of neurogenesis- from centrosome to engineering migration (NeuroCentro)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 2256834.0
EU funding (EUR): 2256834.0
Participants: 1
Project status: SIGNED

The centrosome is a crucial cellular organelle involved in many functions especially during development where it acts to regulate key processes, such as cell division, cilia formation and migration. While many mutations in centrosome-associated proteins lead to diseases often predominantly affecting the brain, the basis for this specificity is in most cases not known. Likewise, basic aspects of centrosome biology, such as the role of RNAs at the centrosome, are largely unknown. Our recent discovery of novel centrosome-associated proteins in human neural stem cells revealed specific RNA-binding proteins at the sub-distal appendages of centrosomes with significant and selective associations to periventricular heterotopia (PH), a neuronal migration disorder. This provides a unique entry point to explore, in the first part of this project, fundamental questions associated with the role of RNAs and RNA-binding proteins at the centrosome and their contribution to neurodevelopmental disorders. In the second part, we will explore changes in centrosome composition from NSCs to young migratory neurons and identify the role of the centrosome in neuronal subtype-specific migration modes using the novel centrosome protein Akna as entry point. In the third part, we will utilize our advanced tools for dCas9 multiplexed transcriptional engineering to restore centrosome function of ectopic neurons and revert migration defects causing PH. These rescue attempts will be extended to later stages of development aiming to revert differentiated glia, the ependymal cells, to radial glial cells, that serve as guides for migrating neurons. This work will thus tackle fundamental functions of neural-specific centrosome proteins, laying the basis to understand the brain-specific phenotype of mutations in factors that are widely expressed but predominantly affect the brain.

Keywords: neural stem cells,neurogenesis,neuronal migration,centrosome
An Activity-based Protein Profiling-supported Protein Therapeutic Drug discovery platform for the development of innovative anti-cancer therapies based on Lin28 inhibition (ABPP-PROTDRUG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Cancer remains one of the most prevalent diseases worldwide and new therapeutic targets are highly sought. The oncogenic triangle LIN28/HMGA2/IGF2BP1 is a self-promoting pro-tumorigenic group of proteins with relevant roles in many cancers that antagonize the let-7 family of miRNAs, which possess anti-tumorigenic roles. Activity-based protein profiling applied to the measurement of cysteine reactivity profiles has been efficiently used to profile the landscape of ligandable cysteines in a given phenotype, which in turn has allowed the discovery of novel therapeutic targets in relevant disease phenotypes and the pharmacological modulation of targets previously described as undruggable. Our approach will characterize the influence of the LIN28/HMGA2/IGF2BP1 proteins in the cellular landscape of ligandable cysteines, focusing on liver and ovarian cancer. Additional protein interacting partners to the oncogenic triangle will be identified and validated as novel anti-tumor targets. Variations in the probes used will allow the established methodology to be adapted to other entities like serine hydrolases, well known players in cancer and metastasis, or sulfenic acids, oxidized cysteines known to take part in redox control of the cellular environment. Cysteine labeling chemistries and protein engineering will be used to weaponize LIN28/HMGA2/IGF2BP1 and their protein interactors against the oncogenic triangle as “protein drugs” via proximity-enabled reactive therapeutics, where reactive aminoacids are introduced in a native protein structure to allow a transient non-covalent interaction to be stabilized by formation of a permanent covalent bond. This approach is at the frontline of novel therapeutic methodologies and its application will restore the levels and function of let-7 miRNAs and their anti-tumor properties. The outcome of this project will establish a powerful platform to weaponize transient non-covalent interactions as innovative therapeutic modulators.

Keywords: activity based protein profiling,protein engineering,protein drugs,cancer,mirna
Econometrics for Public Policy: Sampling, Estimation, Decision, and Applications (EPP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2022-01-31
Duration (months): 60.0
Total project cost (EUR): 1291064.0
EU funding (EUR): 1291064.0
Participants: 1
Project status: SIGNED

One of the ultimate goals of economics is to inform a policy that improves welfare. Despite that the vast amount of empirical works in economics aims to achieve this goal, the current state of the art in econometrics is silent about concrete recommendation for how to estimate the welfare maximizing policy. This project addresses statistically optimal and practically useful ways to learn the welfare-maximizing policy from data by developing novel econometric frameworks, sampling design, and estimation approaches that can be applied to a wide range of policy design problems in reality. Development of econometric methods for optimal empirical policy design proceeds by answering the following open questions. First, given a sampling process, how do we define optimal estimation for the welfare-maximizing policy? Second, what estimation method achieves this statistical optimality? Third, how do we solve policy decision problem when the sampling process only set-identifies the social welfare criterion? Fourth, how can we integrate the sampling step and estimation step to develop a package of optimal sampling and optimal estimation procedures? I divide the project into the following four parts. Each part is motivated by important empirical applications and has methodological challenges related to these four questions. 1) Estimation of treatment assignment policy 2) Estimation of optimal policy in other public policy applications 3) Policy design with set-identified social welfare 4) Sampling design for empirical policy design

Keywords: microeconometrics,program evaluation,decision theory,partial identification,machine learning
A Global Social Sciences Network for Infectious Threats and Antimicrobial Resistance (SoNAR-Global)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Coordination and support actions
Countries involved: Austria,Germany,Uganda,Ukraine,Italy,Malta,Slovenia,Thailand,France,Netherlands,Netherlands,Senegal,United Kingdom,Bangladesh,United Kingdom
Call: Establishment of an International Network of Social Sciences Research Centres to help address governance and other challenges in the preparedness for and the response to infectious threats (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2022-06-30
Duration (months): 42.0
Total project cost (EUR): 4306347.5
EU funding (EUR): 4306347.5
Participants: 15
Project status: CLOSED

SoNAR-Global is a global consortium led by social scientists specializing in emerging infectious diseases (EID) and antimicrobial resistance (AMR). It will build a sustainable international social science network to engage the active participation of social sciences and promote complementarity and synergy in the governance of prevention and response to infectious threats and AMR. As such, it will become an integral part of emergency response. Partnering with major international and regional institutions, it will lead activities through a program that builds governance from the ground up. It will: • Develop an open-access platform to support the SoNAR-Global activities and to share them broadly. • Adapt, test, and evaluate vulnerability assessment tools on the ground and engagement models to facilitate collaboration across multiple stakeholders. • Create, pilot, and evaluate curricula for training social scientists in preparedness and response to infectious threats and through curricular development and piloting social science knowledge of infectious threats among non-social sciences actors.

Keywords: social sciences network,vulnerability,one health,engagement models,curriculum development,antimicrobial resistance,infectious disease management,resilience,social anthropology
OriginIoT - novel platform for increased utilization of GNSS constellations via outdoor IoT products (OriginIoT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Israel
Call: Engaging SMEs in space research and development (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-04-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project addresses a common need among IoT product developers stemming from the challenge of placing GNSS modules in proximity to other electronic components; and the shortage of experienced developers required for IoT (RF, electric, embedded software). OriginIoT is a novel, highly-integrated cellular IoT system designed to shorten development time and drastically reduce costs of IoT projects. The system facilitates increased utilization of GNSS constellations by integrating OriginGPS’ unique GNSS modules in the product, overcoming GNSS/cellular integration challenges out-of-the-box. Additionally, the product encapsulates a unique method of sensor operation from a remote cloud, freeing the developer from developing embedded code. With OriginIoT™, one can develop a complete location-aware, cellular IoT device in only six weeks, with ~85% cost savings. The European GSA defined IoT as one of the macrotrends that will contribute to the growth of GNSS devices install base from 5.8 bln GNSS devices in use in 2017 to almost 8 bln in 2020; the OriginIoT has the potential to become one of the main enablers in this area as it is tailored for the needs of this particular type of developers. Potential users for this technology can come in the forms of start-ups, "traditional" products that wish to add IoT value and large companies who needs to implement an IoT project quickly and efficiently. Under phase 1 we wish to test the ability to produce this device in small-form factor allowing high GNSS performance, develop commercial materials and plan to introduce this product and design a detailed work-plan for phase 2. This project can assist the growing European innovation ecosystems, providing them with the perfect solution for quick IoT roll-out.

Keywords: gnss,galileo,internet of things,product development,prototyping,platform
The First Driver-Minded Electric Compact Street-Sweeper (GluttonZen)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Glutton®Zen®, is a compact all-electric city sweeper vehicle that will transform the market of cleaning cities services by offering an autonomous, no emissions waste capturer vehicle. A compact street sweeper machinery which is primarily used for the purpose of waste removal in the cities and other areas such as highways, airport roads and in industries. The first operational prototype was completed in early 2017 and has now been successfully demonstrated. Glutton®Zen® includes a regenerative engine that recuperates kinetic energy (adding 90 minutes over an 8-hour shift) for longer autonomy helping the Glutton®Zen® to reach a class-leading 10-hour guaranteed, and contains a proprietary filter that retains 99.9% of particulate matter in the air. It has also an enhanced ergonomically-minded cabin with accessories intended to dignify and give value to the driver’s work. We added a proprietary; all unique advantages that make the Glutton®Zen® the leading candidate for municipal tenders on electric sweepers.

Keywords: city cleaning services,smart cities,co2 emissions,electric vehicles,compact sweeper,local authorities