Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
BiFoldome: Homo- and Hetero-typic Interactions in Assembled Foldomes (BiFOLDOME)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 1496823.0
EU funding (EUR): 1496823.0
Participants: 1
Project status: SIGNED

Self-assembly is a fundamental foundation of life, but what about co-assembly? The main goal of BiFOLDOME is to decipher co-assembly to understand self-assembly. Amyloids were assumed to be assembled by one type of protein, but our recent elucidation of the first 1:1 hetero-amyloid structure (the RIPK1-RIPK3 necrosome core) suggests that amyloids composed of two distinct proteins playing key roles in health and disease may be common. In fact, a viral protein (M45) can displace one partner (RIPK1) to form a distinct 1:1 hetero-amyloid (M45-RIPK3). Taking a leaf from the viral playbook, this means that for a given self-assembling sequence there may be a mating sequence driving the preferential 1:1 co-assembly of the two. Thus, understanding what drives the preferential formation of co-assembled forms over conventional self-assembled species will afford an entirely new vision on assembly processes transversal to all fields of knowledge. BiFOLDOME is organized around three different levels of complexity: (1) characterizing the formation, structure and energetics of representative paradigms of 1:1 co-assembled amyloids using solution and solid-state NMR spectroscopies, and energy calculations, featuring novel technical innovations that we will develop. This will provide the basis for self-assembly by delivering a firm understanding of co-assembly. (2) Applying the fundamental knowledge from (1) to the manipulation of self-assembled, disease-associated proteins using the powerful concept of 1:1 co-assembly. (3) Going beyond the state of the art by developing a new methodology to study the assembly of biomolecular condensates. The approach, which I call “optoNMR”, will enable controlled, light-triggered self- and co-assembly of proteins within the NMR tube, opening new avenues to discern between alternative hypotheses for condensate formation and hardening in real-time and at high resolution, or for sensitive detection using hyperpolarization schemes.

Keywords: supramolecular assembly nmr structural biology light nmr biological chemistry ripk1 ripk3 tdp 43 1 1 hetero amyloid condensates self assembly co assembly amyloids rhim computational chemistry
STRUCTURAL RELIABLE OFFSHORE FLOATING PV SOLUTION INTEGRATING CIRCULAR CONCRETE FLOATING BREAKWATER (SUREWAVE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Norway,Spain,Netherlands,Germany
Call: Innovative foundations, floating substructures and connection systems for floating PV and ocean energy devices (HORIZON-CL5-2021-D3-03, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 3515097.5
EU funding (EUR): 3515097.5
Participants: 7
Project status: SIGNED

SUREWAVE will develop and test an innovative concept of Floating Photo-Voltaic (FPV) system consisting of an external floating breakwater structure acting as a protection against severe wave-wind-current loads on the FPV modules, allowing increased operational availability and energy output, thus unlocking the massive deployment of Offshore FPV. It will be focused on the research for securing optimal behaviour at aero & hydrodynamic and structural integrity level of the external breakwater, the internal FPV modular structure, the connections, the mooring and anchoring and the whole FPV system, complying with mechanical, electrical (maximizing energy output) and cost-efficiency requirements, ensuring high lifetime of critical components, high reliability of the system and easy, quick and cost-efficient, construction, installation and O&M of the whole system. This will require: 1) the development of novel circular concrete material solutions for the breakwater, cost-effective, easy to produce and with high mechanical, physical and durability properties and low CO2 footprint. 2) the development of an advanced predictive computational modelling and simulation framework: coupled aero & hydrodynamic modelling, Structural integrity modelling, material properties modelling and Structural Health Management to reduce CAPEX and OPEX; 3) the design and implementation of an optimal testing and validation methodology for offshore FPV system to achieve TRL5, including lab testing, basin-model testing and marine environment testing of critical components assuring high resilience to corrosion and biofouling. Maximum advantage of existing expertise will be taken from experts in: offshore wind floating structures, material and phenomena modelling (SINTEF, MARIN, CEIT), design and installation of FPV in calm waters (SIS), floating solutions (CLEMENT), circular structural and non-structural materials (ACC) and in social, environmental and economic assessment (IFEU).

Keywords: offshore floating photovoltaic,fpv,aerodynamic,hydrodynamic,wave breaker,new circular concrete materials,anchoring,mooring,modeling and simulation tools,structural health management
Consumer Demand Flexibility in Electricity Use (CoDeF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland,Germany,Norway,Belgium,Denmark,Netherlands,Lithuania,Switzerland,Finland
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 3635604.0
EU funding (EUR): 3635604.0
Participants: 25
Project status: SIGNED

The project CoDeF pursues the primary objective of training innovative and expert doctoral researchers with a combination of strong research skills and key transferable competencies to face the challenges presented by an emerging aspect of the clean energy transition, consumer energy flexibility. The network integrates the variety of disciplines needed to study consumer energy flexibility and will train participants in research and transferable skills to progress and deliver state of the art research in their fields. Consumers and citizens will play an important role in the transition to net zero carbon energy through flexible energy use and matching demand to available renewable energy supply, thus reducing the need for fossil fuel generation and consumer energy bills. Nonetheless, technical, economic, and societal challenges currently hinder consumer participation in energy markets. The scientific research focuses on three objectives related to the increased participation of consumers in the provision of demand flexibility: - Incentives and behaviour: how to incentivise consumer flexibility through behavioural change, demand response interventions, and markets. - Enabling frameworks: how to facilitate flexible consumer demand through enablers, such as control algorithms and smart grids, smart devices in the home, and institutional frameworks. - Impact assessment: evaluating the impact of consumer energy flexibility on emissions, the energy system and society. Each doctoral candidate will carry out specialised research related to one of the objectives, in cooperation with their supervisors and interlinked with other researchers and associated partners of the consortium. Collectively, the doctoral network delivers multidisciplinary, integrated, innovative research outcomes for energy policy and society and a cohort of expert researchers equipped to realise the clean energy transition.

Keywords: consumer behaviour,households,energy flexibility,electricity markets
Amenable C*-dynamics and their classification (AMEN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1940875.0
EU funding (EUR): 1940875.0
Participants: 1
Project status: SIGNED

Our understanding of amenable C*-algebras has drastically improved over the past decade due to substantial advances in the Elliott classification program. The proposed research is intended to spearhead the classification and structure theory for C*-dynamics, which encompasses groups acting continuously on C*-algebras and the question to which extent their detailed structure is encoded at the level of computable invariants. The objectives involve the following lines of investigation: - The case of discrete groups acting on simple amenable C*-algebras, the latter of which have become accessible due to recent methodological breakthroughs within Elliott's program. The task is to develop a dynamical version of Elliott's program, i.e., to consider natural categories of such group actions, identify functorial invariants such as K-theory and traces, and show that these invariants completely classify a naturally occuring category up to a suitable notion of isomorphism. - The theory of invariants for noncommutative C*-dynamics. This field is faced with numerous open problems requiring solutions before a fully general classification theory can be developed. This part of the project addresses the need for effective computational methods for equivariant Kasparov classes, or systematic techniques to exploit equivariant Ext-theory for the purpose of classification. - The case of noncommutative time evolutions, which includes new rigidity phenomena for the passage of time in simple C*-algebras, both with and without the presence of equilibrium states. A deeply rooted theme within all these objectives is the presence of amenability for the actions and the C*-algebras, which gives rise to radically new phenomena in the context of non-amenable acting groups. Drawing ideas from diverse areas such as the Elliott program, equivariant Kasparov theory, classical and noncommutative ergodic theory, novel methods are proposed to achieve groundbreaking results in the area of C*-dynamics.

Keywords: c dynamical systems cocycle conjugacy classification of c algebras elliott program amenability
FOODCoST: FOOD Costing and Internalisation of Externalities for System Transition (FOODCoST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Netherlands,Hungary,Italy,Belgium,France,Germany,Portugal,Denmark,Slovakia,Sweden,Spain,Romania,United Kingdom
Call: Towards an EU approach to assess and internalise positive and negative externalities of food for incentivising sustainable choices (HORIZON-CL6-2021-FARM2FORK-01, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 7355092.5
EU funding (EUR): 7355091.5
Participants: 26
Project status: SIGNED

Ensuring sustainable food systems requires vastly reducing its environmental and health costs while making healthy and sustainable food affordable to all. In current food systems many of the costs of harmful foods and benefits of healthful foods are externalized, i.e. are not reflected in market prices and therefore not in decision making of actors in food value chains. Solving the externality problems means to determine current costs of externalities and redefine food prices (true pricing) to internalize them in daily practice. Policy makers, businesses and other actors in the food system, lack sufficient information and knowledge to internalize externalities to achieve a sustainable food system. FOODCoST responds to this challenge by designing a roadmap for effective and sustainable strategies to assess and internalise food externalities. FOODCoST provides approaches and databases to measure and value positive and negative externalities, proposing a game-changing and harmonised approach to calculate the value of climate, biodiversity, environmental, social and health externalities along the food value chain based on economic cost principles. FOODCoST provides an analytical toolbox to experiment, analyse, and navigate the internalisation of externalities through policies and business strategies providing tools and guidance to policy makers and businesses to assess the sustainability impact of their internalisation actions. FOODCoST emphasises the diversity of challenges of true pricing in different value chains and countries and regions, and cocreates, tests and validates the valuation and internalisation approaches in 11 diverse case studies enabling to test, validate and enrich the approaches in order to transit towards a sustainable food system. The project will be based on a multi-actor approach that will ensure a continuous dialogue with all relevant actors across the whole food system (land and sea).

Keywords: externalities,multi actor approach,economic policy modeling,valuation,internalization,impact assessment
Open-source ReSilient Hardware and software for Internet of thiNgs (ORSHIN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Research and Innovation actions
Countries involved: Austria,Belgium,France,Germany,Italy,Czechia
Call: Improved security in open-source and open-specification hardware for connected devices (HORIZON-CL3-2021-CS-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 3814500.0
EU funding (EUR): 3814500.0
Participants: 7
Project status: SIGNED

It is common wisdom that security is only as strong as the weakest link in a chain. However, identifying the chain and its weak links is a huge challenge, even more so for open-source hardware aimed at the Internet of Things (IoT), industrial IoT and critical infrastructure. Most of these devices operate in constrained environments, with limited energy budgets and routinely lack essential security and privacy guarantees. The primary goal of the ORSHIN project is to create a generic and holistic methodology, which we call the ‘trusted life cycle’ to develop and manage connected devices based on open-source hardware. We identified a chain of six essential phases: Design, Implementation, Evaluation, Installation, Maintenance, and Retirement. The life cycle will specify how to translate abstract security goals (e.g., build a secure IoT product) into security policies for the phases, and further into concrete security requirements for the building blocks of the product (e.g., use 128-bit keys). Using this holistic view, ORSHIN will address critical links, corresponding to three important expected outcomes mentioned in the call, to reduce the security threats associated with open-source connected devices: 1. We will propose new models of security properties in order to extend formal verification to the secure, open-source hardware realm. 2. To enable effective security audits of open-source hardware and embedded software, we will develop practical, fast, and hardware-augmented testing techniques. 3. We will create secure and privacy-preserving protocols for intra-device and inter-device communication to provide secure communication and authentication methods for connected devices. These ambitious objectives, leading to open-source demonstrators at TRL4, are proposed by an international consortium with complementary experience, consisting of four high-tech SME’s in collaboration with two excellent academic partners and one important European semiconductor company.
Dissecting Brain Pollutant Exposure and its Contribution to Neurodegeneration and Alzheimer’s disease: From Signatures to Prevention Strategies to Protect and Maintain a Healthy Brain (EXPOSIGNALZ HOP-ON)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: France,Cyprus
Call: Hop-on facility (HORIZON-WIDERA-2025-03, 2025)
Duration (months): 48.0
Total project cost (EUR): 587195.0
EU funding (EUR): 587195.0
Participants: 2
Project status: CLOSED

Environmental pollutants constitute significant risk factors for Alzheimer's disease (AD), yet the circuit-level mechanisms linking exposure to neurodegeneration remain insufficiently defined. Building on EXPOSIGNALZ's identification of neurotoxic compounds and pro-amyloidogenic chemical signatures, University of Cyprus (UCY) will investigate causal relationships between pollutant exposure and brain circuit function using cutting-edge systems neuroscience approaches. We will examine how exposure to anilinopyrimidine fungicide cocktail and environmentally relevant toxicants with neurotoxic effects and pro-amyloidogenic properties perturbs key memory circuits in mouse models. Specifically, UCY will determine whether pollutant exposure accelerates AD-related cognitive decline through circuit dysfunctions using: (1) ex vivo electrophysiology to identify synaptic plasticity alterations in Schaffer collateral and temporoammonic pathways; (2) in vivo fiber photometry to monitor real-time calcium dynamics during memory tasks; and (3) electroencephalography to capture hippocampal-prefrontal network impairments. Additionally, UCY will assess developmental circuit disruption through maternal pollutant exposure models, mapping synaptic plasticity changes from early post-natal stages to aging. To establish therapeutic proof-of-concept, targeted optogenetic interventions will be applied to test whether timely restoration of circuit function can mitigate or prevent cognitive decline. This approach will generate the first translational biomarkers of pollutant-induced circuit dysfunction, define critical developmental windows of susceptibility and evaluate potential rescue interventions. The outcomes will directly advance EXPOSIGNALZ’s objectives of reducing AD incidence through early detection and intervention strategies, while establishing UCY as a reference center for environmental neurotoxicity research and contributing to evidence-based brain health protection policies.

Keywords: environmental pollutants brain health dementia alzheimer
Closing the gap between fork and farm for circular nutrient flows (P2GreeN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Innovation actions
Countries involved: Germany,France,Ireland,Sweden,Denmark,Finland,Greece,Spain,Cyprus,Italy,Belgium,Switzerland,Hungary,Netherlands
Call: Piloting innovative governance solutions to limit nitrogen and phosphorus emissions at the interface of rural/coastal and urban/industrial environments (HORIZON-CL6-2022-ZEROPOLLUTION-01, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 8409921.58
EU funding (EUR): 7250117.0
Participants: 35
Project status: SIGNED

P2GreeN will foster a paradigm shift, from a linearly organised resource and nutrient system within the agri-food supply chain, towards a circular material flow system between urban and rural areas thereby restoring the coupling of the water-agri-food system using a holistic symbiotic resource management approach following the 3R principle “Reduce, Reuse, Recover”. P2GreeN will therefore develop new circular governance solutions for the transition from fork to farm to halt and eliminate N & P pollution by connecting blue urban with green rural infrastructure, focussing on circular nutrient flows of nitrogen (N) and phosphorus (P). This will be done trough implementation and demonstration of innovative N & P recovery solutions for the utilisation of human sanitary waste from urban settlements and its conversion into safe bio-based fertilisers for agricultural production in three pilot regions (P2GreeN pilot regions) on a north-south trajectory from the Baltic Sea region via the metropolitan area of Hamburg-Hannover to the region of Axarquia in Southern Spain. This approach will be extended to follower region in Italy, France, Greece and Hungary. P2GreeN will close nutrient cycles of N & P to foster the transition towards a circular and clean economy (green transition) as well as supporting sustainable food systems from farm to fork offering viable alternatives to reduce the current usage of mineral fertilisers with innovative Green bio-based fertilisers and thus minimise the pressure on the natural resources, specifically water and soil. P2GreeN will further enable policy makers to replicate P2GreeN’s sustainable regional circular economy models in all regional settings across Europe. To facilitate systemic change, co-creation strategies including the participation of all relevant stakeholders as well as harmonised governance frameworks that foster innovations will be key to P2GreeN.

Keywords: circular nutrient flows n and p,blue urban and green rural infrastructure,biobased fertilizers,symbiotic resource management,circular business models,blueprint governance framework