Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Targeting dendritic cell plasticity to modulate antigen-specific T cell recall responses in human (plasTCD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

The human immune system has the ability to fight various infectious diseases or self-cells turning malignant. Dendritic cells (DCs) are innate immune sensors and professional antigen presenting cells that initiate the development of adaptive immune responses towards the formation of memory cells. Very important studies deciphered the various signals in DCs to effectively polarize naïve T cells. However, a significant gap of knowledge remains on how DCs can mediate and influence antigen-specific T cell recall responses. In this program, we aim to investigate how the different human DC subsets can modulate antigen-specific T cell recall responses directed against influenza (Flu) epitopes. To this end, we have designed a set of highly integrated work packages: WP1: Using a systematic experimental approach of challenging co-cultures of pure DCs (6 different subsets) and Flu-specific T cells from healthy subjects, we will generate a functional atlas revealing the impact of the different DC subsets on antigen-specific T cell recall responses. T cell response status will be assessed at the protein level using phenotypic and functional approaches on multimer positive T cells. WP2: Using CITE-seq technology together with cutting-edge system biology platforms, we will interrogate the transcriptomic programs and molecular pathways associated with antigen-specific T cell recall responses following stimulation with the various DC subsets. WP3: As a complementary analysis of the data generated in WP2, we will perform TCR repertoire analysis to compare the clonal composition of the responding antigen-specific T cells. This program represents an ambitious and promising project that will generate novel biological insights into fundamental immunological mechanisms of human DC-T cell communication. Such information could have direct clinical impact on the design of therapeutic DC-based vaccines, immunotherapies targeting DCs or T cell expansion protocols for adoptive transfer therapy

Keywords: dendritic cells,antigen specific t cells,recall responses,immunotherapy,vaccine
FOG-aided wireless networks for communication, cacHing and cOmputing: theoRetical and algorithmic fouNdations (FOGHORN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2023-07-31
Duration (months): 74.0
Total project cost (EUR): 2318719.0
EU funding (EUR): 2318719.0
Participants: 1
Project status: SIGNED

The FOGHORN project aims at developing the theoretical and algorithmic foundations of fog-aided wireless networks. This is an emerging class of wireless systems that leverages the synergy and complementarity of cloudification and edge processing, two key technologies in the evolution towards 5G systems and beyond. Fog-aided wireless networks can reap the bene fits of centralization via cloud processing, in terms of capital and operating cost reductions, greening, and enhanced spectral e fficiency, while, at the same time, being able to cater to low-latency applications, such as the "tactile" internet, by means of localized intelligence at the network edge. The operation of fog-aided wireless networks poses novel fundamental research problems pertaining to the optimal management of the communication, caching and computing resources at the cloud and at the edge, as well as to the transmission on the fronthaul network connecting cloud and edge. The solution of these problems challenges the theoretical principles and engineering insights which have underpinned the design of existing networks. The initial research activity on the topic, of which the EU is at the forefront, focuses, by and large, on ad hoc solutions and technologies. In contrast, the goal of this project is to develop fundamental theoretical insights and algorithmic principles with the main aim of guiding engineering choices, unlocking new academic opportunities and disclosing new technologies. The theoretical framework is grounded in network information theory, which enables the distillation of design principles, along with signal processing, (non-convex) optimization, queuing and distributed computing to develop and analyse algorithmic solutions.

Keywords: network information theory,wireless networks
New competence for building professionals and blue collar workers – certified qualification schemes to upgrade the qualification for building nZEBs (NEWCOM)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Austria,Austria,Hungary,Slovakia,Netherlands,Netherlands
Call: Construction skills (H2020-EE-2016-CSA, 2016)
Start date: 2017-09-01
End date: 2020-11-30
Duration (months): 39.0
Total project cost (EUR): 1120562.5
EU funding (EUR): 1120562.5
Participants: 7
Project status: CLOSED

In order to implement the EPBD systematically and thereby reach the EU's energy and climate targets, building owners, constructors and municipalities should be aware of how energy saving measures have to be planned, applied and monitored. The buildings being built or renovated now, are the building stock of the future. Therefore, it is important to pay attention to the quality of work on construction site. Construction errors are responsible for most of poor energy performance of buildings in practice. Reasons for this are often lack of awareness of workers on construction sites making relevant parts of the building envelope or the HVAC systems regarding the complexity of nearly zero emission buildings. This is because of the very limited availability of further education in the construction sector in many countries around Europe especially with the focus on mutual recognition. Furthermore, actual offered courses in the building sector do not cover topics like cross craft understanding, lifelong service approaches, continuous controlling and monitoring or BIM-tools which are very important for the construction and maintenance of nZEBs. In addition, quality control also lacks in many cases. NEWCOM addresses challenges of raising building quality that supervisory authorities are facing today in order to achieve the European and national climate protection targets for 2020 and the implementation of the nearly zero-energy buildings standards. NEWCOM focuses on the development of missing qualification and certification schemes for blue collar workers and building professionals who inspect and control the most relevant qualities with a specific focus on mutual recognition. By the project “NEWCOM” the number of blue collar workers and building inspectors with special nZEB competence will be increased, the quality of buildings (focus energy efficiency) raised and the market recognition of well-skilled professionals across the building sector in European market boosted.

Keywords: blue collar workers,professionals,certification,mutual recognition
NarcoScan pocket-sized and affordable narcotics screener: making drug detection on the streets as common as catching drunk drivers (NarcoScan)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Finland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-09-01
End date: 2019-06-30
Duration (months): 22.0
Total project cost (EUR): 3365625.0
EU funding (EUR): 2355937.5
Participants: 1
Project status: CLOSED

Every year, EU citizens spend over €24 billion on illicit narcotics. Over 29 million people globally suffer from drug abuse – which is more people than all the Nordic countries combined. The key to limiting drug proliferation lies in the first-responder law enforcement to effectively detect narcotics in the field. However, the current tools and ways of working are not efficient in making quick and correct arrests of drug criminals, nor for discovering criminal organisations. We are introducing NarcoScan – the first pocket-sized scanner for first responders, such as police patrols, to quickly and accurately detect any type of illicit narcotics on the street. Being 20+ times less expensive than alternatives, NarcoScan uniquely enables mass-deployment of narcotics screeners. By combining our innovative spectral sensing technology with cloud and device-to-device connectivity, we have arrived at a disruptive solution that will make screening narcotics on the streets as ubiquitous as breathalysers for detecting drunk drivers. Our drug database is updated as soon as new narcotics appear on the streets, and the updates are deployed immediately across all the scanners on the field – just like antivirus databases are updated in computers. NarcoScan will bring at least €125 million in direct cost savings per year to the European criminal justice system. The impact of our solution extends further to the European society by reducing the size of illegal economy, improving the efficiency of police work (faster arrests, faster confessions, avoiding false arrests), and contributing to building healthier and more secure environments. Having proven the technical and economic viability of our solution through extensive feasibility studies, the main goal of our Phase 2 project is to prepare for global growth by building our technical backbone into a globally scalable and rich technical solution.

Keywords: spectroscopy,sensor,cloud,miniaturisation,connectivity,machine learning,mass deployment
Effective Management of Pests and Harmful Alien Species - Integrated Solutions (EMPHASIS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Spain,Spain,Italy,Hungary,Belgium,Latvia,France,Czechia,Netherlands,Netherlands,Netherlands,United Kingdom,Canada,United Kingdom,United Kingdom
Call: Native and alien pests in agriculture and forestry (H2020-SFS-2014-2, 2014)
Start date: 2015-03-01
End date: 2019-02-28
Duration (months): 48.0
Total project cost (EUR): 6636039.5
EU funding (EUR): 6526038.51
Participants: 24
Project status: CLOSED

EMPHASIS is a participatory research project addressing native and alien pests threats (insect pests, pathogens, weeds) for a range of both natural ecosystems and farming systems (field crops, protected crops, forestry, orchards and amenity plants). The overall goal is to ensure a European food security system and the protection of biodiversity and of ecosystems services while developing integrated mechanisms of response measures (practical solutions) to predict, to prevent and to protect agriculture and forestry systems from native and alien pests threats. The specific objectives are the following: 1.Predict, Prioritize and Planning: pest management challenges and opportunities will be evaluated according to stakeholder-focused criteria and through pathway analysis; 2.Prevent: practical solutions for surveillance in different pathways to enhance preparedness will be provided to end-users, and monitoring tools following outbreaks and eradication will be developed; 3.Protect: practical solutions for managing native and alien pests in agriculture, horticulture and forestry will be developed, their technical and economic feasibility will be demonstrated and their market uptake will be enhanced. 4.Promote: a mutual learning process with end-users will be developed, and the solutions identified by the project will be promoted through training and dissemination. The project is in line with EU policy framework (Plant Health Dir. 2000/29/EC, EU Biodiversity strategy to 2020, Dir. 2009/128/EC on sustainable use of pesticides, Roadmap to a Resource Efficient Europe) and its future developments (Reg. on protective measures against pests of plants, Reg. on Invasive Alien Species). The project is not focused on a single management systems but the plant/pest ecosystems dealt with are treated with a multi-method approach to design true IPM methodology that will be developed for key systems with portability to other similar systems, thereby having a large impact.

Keywords: pathway analysis,surveillance,lamp assays sentinel crops,next generation sequencing,dna barcoding host plant resistance,semiochemicals,cultural control,optimized chemical control,co innovation
Elucidating natural bilayer lipid environments (ENABLE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-06-01
End date: 2021-05-31
Duration (months): 60.0
Total project cost (EUR): 2481744.0
EU funding (EUR): 2481744.0
Participants: 1
Project status: CLOSED

Excising a membrane protein from its natural environment, preserving the lipid bilayer, and characterising the lipids that surround it is the ‘holy grail’ of membrane protein biophysics. However, with some 40,000 different lipid structures the challenges we face in understanding selective binding arise not just from the complexity and dynamics of the lipidome, but also from the transient nature of protein lipid interactions. To overcome these challenges we will take mass spectrometry (MS) into a new era, allowing, for the first time, the study of proteins in an environment as close as possible to the natural one. To do this we will (i) characterise protein lipid interactions by employing a high resolution Orbitrap mass spectrometer developed in-house, specifically for membrane proteins, (ii) capture the native lipid environment in vehicles suitable for use in conjunction with MS, and (iii) establish a new platform to be known as integral membrane protein desorption electrospray ionization (impDESI). Designed and built in-house impDESI is capable of releasing membrane proteins from surfaces directly into the mass spectrometer (MS). We will develop impDESI for membrane mimetics, and subsequently portions of natural membranes, enabling us to extract proteins with oligomeric state preserved and native lipid binding intact. The development of impDESI, in conjunction with high resolution Orbitrap MS, and coupled with the optimisation of membrane mimetics, has the potential to radically transform our understanding of native lipid binding, not only directly, but also temporally and spatially. Together these advances will answer key questions about how lipids modulate protein interfaces, occupy different binding sites, modulate membrane protein structure and modify function in vivo. Given the importance of membrane proteins as potential drugs targets understanding their modulation by lipids would be a major step towards more effective drug development.

Keywords: mass spectrometry of non covalent interactions,membrane proteins
CO2 reconstruction over the last 100 Myr from novel geological archives (OldCO2NewArchives)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2024-10-31
Duration (months): 69.0
Total project cost (EUR): 1996784.0
EU funding (EUR): 1996784.0
Participants: 1
Project status: SIGNED

CO2 exerts a major control on Earth’s environment, including ocean acidity and global climate. Human carbon emissions have elevated CO2 levels to above 400 ppm, substantially higher than at any time in the 800,000 year ice core record. If we want to understand how Earth’s environment and climate will respond to a high CO2 world, we need to look deeper into the geological past. This project provides a novel way to reconstruct ocean pH and atmospheric CO2 levels over the last 100 Myr. This will allow us to fathom the fundamental mechanisms governing Earth’s environmental evolution, and improve predictions of environmental response to CO2 change in the future. Atmospheric CO2 and ocean pH are closely coupled, because CO2 is acidic and is readily exchanged between the ocean and atmosphere. If ocean pH is known, we can place strong constraints on atmospheric CO2. Thanks to recent developments in geochemistry, it is possible to reconstruct changes in ocean pH using the boron isotope composition (d11B) of fossil shells. The well-studied systematics of this method and its underlying thermodynamic framework provide confidence in its application to the geological record. However calculation of pH from carbonate d11B requires knowledge of the boron isotope composition of past seawater d11Bsw. Here I propose novel strategies and techniques with new or underutilized archives (evaporites, shallow carbonates, and infaunal foraminifera) to constrain this crucial parameter. With d11BSW constrained, new d11B records from benthic foraminifera will provide a 100 Myr record of ocean pH. This benchmark reconstruction will be used to test key hypotheses on major environmental change in the geological record, and to constrain atmospheric CO2 using a state-of-the-art biogeochemical model. These paired data and modelling outcomes will provide a major step forward in our understanding of the fundamental processes regulating Earth’s climate and long-term habitability.

Keywords: boron,palaeoceanography,seawater chemistry,biominerals
Tracking and Targeting Tumor States at single-cell resolution in real time in vivo (TrackingTumorStates)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Belgium
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

It is now widely recognized that within a tumor, not all cancer cells are alike and different tumor states (TS) exist. This process is known as tumor heterogeneity. Some cancer cells actively proliferate, while others differentiate, migrate and give rise to metastasis, or enter in a dormant state and resist to chemotherapy. The identification of distinct TS and the mechanisms that regulate their identities and functions is critical for our understanding of tumor heterogeneity. The different TS can acquire distinct phenotypes responsible for tumor progression, metastasis, and therapy resistance. In this project, using multidisciplinary approaches that combine single-cell lineage tracing, single-cell genomics, epigenomics and transcriptomics together with pharmacological treatment and genetic perturbations, we will define in a comprehensive and integrated manner the identities and functions of distinct TS at single-cell resolution in squamous cell carcinoma (SCC). Then, we will develop new genetically engineered tumor models expressing different fluorescent proteins to visualize the dynamics of TS in real time in vivo using intravital microscopy. Moreover, we will assess the roles of the identified TS by lineage ablation and identify the intrinsic and extrinsic mechanisms that regulate their transitions and functions, which will help to define new tumor vulnerabilities and provide new therapeutic opportunities.
Thermoplastic on Doors (TOD)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Italy,Italy,United Kingdom
Call: Full scale innovative composite doors, surrounds and sub-structure for Regional Aircraft Fuselage barrel on-ground demonstrators (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-10-01
End date: 2022-01-31
Duration (months): 40.0
Total project cost (EUR): 1775035.0
EU funding (EUR): 1593572.5
Participants: 4
Project status: SIGNED

The Regional Aircraft IADP will bring the integration of technologies developed in phase one within the Green Regional Aircraft ITD to a higher level of complexity and maturity via two flying test-beds and three large integrated ground demonstrators. The overall goal of the TOD project is to demonstrate rapid manufacturability and validation of a full scale thermoplastic composite door including its surrounding, sub-structure for regional aircraft fuselage barrel. This will be achieved by a tangible step beyond the current state of the art of several thermoplastic manufacturing technologies, some of which are already implemented in other certified aircraft parts. 3 reputable European partners, with a very well-known track-record in their respectively area of expertise, aim to use their background to address the objectives set out in this project. The proposed approach include: • Optimisation and validation of component manufacturing using thermoforming and, joining processes such as, Induction Welding and Resistive Implant Welding, which will enable light weighting by removal of mechanical fasteners. • Take advantage of technology advancement in industry 4.0 automation and on-line monitoring to support higher production rate with high quality performances ( Zero defect) and roubust control.

Keywords: door,door sorround,thermoforming,welding