Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Planning and Evaluation Methodologies for Mental Healthcare Buildings (PEMETH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The study of psychiatric facilities is major for the care of vulnerable people. It is central to the study of therapeutic environment for mental health, great value for understanding mental illness and the psychosocial impact of the built environment and formulating interdisciplinary relations between architecture and health. In Europe, about 20% of the burden of disease relates to mental illness. With low diagnostic and low medical treatment accuracy factor, environment is key for quality of care and patients’ social re-integration. The key questions of this proposal are: (i) how the mechanisms of the environment influence the personal and social milieu of psychiatric space, and (ii) how the environmental needs of the mentally ill are met by wards. Work in other healthcare settings has shed some light on the first, yet little is known about the second. For these, the researcher aims to exploit the scientific tools of architectural morphology (Space Syntax) and juxtapose them with a patient-focused, model for the evaluation of psychiatric environment (the SCP model), to investigate environment in an integrated way. The research will be comparative of two methodologies and will involve facilities in the community as case studies for its physical locus. Those will be examined for their spatial qualities. The findings could set the framework for a model for evidence-based healthcare architecture to serve as design and evaluation tool, immediately accessible to architects and stakeholders. The final product will be design methods and guidelines for healthcare architecture and in particular for community psychiatric facilities immediately accessible to architects. The research is expandable, when environment is important in prevention and care strengthening the area between healthcare from one side and architecture on the other. However, the largest contribution is in architecture, a sector of great potential, yet in need of more interdisciplinary connections.

Keywords: social inclusion,mental health architecture,space syntax,architectural research,psychiatric facilities,architectural morphology,social reintegration,community mental health,social stigma
ERA-NET for Monitoring and Mitigation of Greenhouse Gases from Agri- and Silvi-Culture (ERA-GAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: ERA-NET Cofund
Partnership: ERA-GAS (ERA-NET)
Countries involved: Germany,Germany,Ireland,Germany,Ireland,Norway,Türkiye,Finland,Poland,Sweden,New Zealand,Romania,Latvia,France,Netherlands,United States,Netherlands,Denmark,United Kingdom
Call: Monitoring and mitigation of agricultural and forestry greenhouse gases (GHG) (H2020-ISIB-2015-1, 2015)
Start date: 2016-05-01
End date: 2022-04-30
Duration (months): 72.0
Total project cost (EUR): 15151516.0
EU funding (EUR): 5000000.0
Participants: 22
Project status: CLOSED

The aim of the ERA-GAS Cofund is to strengthen the transnational coordination of research programmes and provide added value to research and innovation on greenhouse gas (GHG) mitigation in the European Research Area. ERA-GAS will organise a single joint transnational call for proposals with cofunding from the European Commission (EC). In addition, ERA-GAS will undertake additional joint activities including at least one other joint call without EC cofunding. By pooling national money and funding projects at a European/international level, ERA-GAS will achieve a critical mass for funding GHG research, thereby reducing duplication, harmonising research effort and making more efficient use of limited resources. Greater cooperation will enhance innovation capacity in the European Research Area and encourage the development of enabling solutions to reduce GHG emissions and improve inventories. ERA-GAS will work closely with other ERA-NETs and reinforce existing collaborations between actors in the research area (e.g. via FACCE-JPI and the GRA). A plan will also be drawn up for future collaborative actions to ensure that enhanced cooperation will be maintained past the lifetime of the ERA-NET. Through collaboration in this ERA-NET and additional joint activities, partners in the consortium will exchange experience and gain insight into other national/regional research programmes. This will help managers to follow best practice in terms of implementing international funding calls and harmonise research and policy agendas across nations. The objectives of ERA-GAS will directly address the scope of the Work Programme by incentivising participating countries to commit resources towards the development of a sustainable, innovative and more GHG efficient bioeconomy in Europe. This transnational effort is urgently required to develop mitigation solutions, refine reporting mechanisms and design policy instruments necessary to tackle this key global environmental challenge.

Keywords: greenhouse gases,monitoring,mitigation,agriculture,forestry,inventories,uncertainties,carbon sequestration,barriers to implementation,reporting,verification,silviculture
Pasteur's Empire - French Expertise, Colonialism, and Transnational Science (PE-FECATS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-11-15
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This project investigates how bacteriologists at the Pasteur Institute reimagined the French empire as a biotechnological space of experimentation in the early twentieth century, and conversely, how medical technologies developed in French colonies in Indochina, West Africa and Tunisia were enrolled to both shore up and challenge colonial power. Scholars are increasingly interested in how global inequalities shape medical development i.e through the outsourcing of clinical trials. Yet most work has focused on the role of politicoeconomic inequalities. This project firstly investigates how the framework of empire interacted with the construction of colonial technoscience - new epidemiological data, laboratory infrastructure - that rendered French colonies legible as spaces of medical experimentation. Scientists turned the colonies into resources they could use to maneuver around metropolitan obstacles such as resistance to large-scale human trials of new vaccines, and push their projects further. Secondly, this project focuses on plague containment, alcohol and opium fermentation, and tuberculosis and yellow fever vaccination, showing how these projects empowered French, Vietnamese and African actors in the realm of politics. French colonial administrators used vaccines and fermentation techniques as examples of rational French progress, imposing reforms that limited labor rights, centralized major industries in French hands, and restricting rights of association for colonial subjects. At the same time, Vietnamese and African activists could leverage the discourse of progress to point to the practical failures of bacteriological technologies, opening up a new language for claiming rights and criticizing the empire. By integrating transnational history with science and technology studies, this project provides a new lens for studying the history of empire and understanding the political consequences of medical development.

Keywords: history of medicine,french history,technopolitics,empire and colonialism
Protometabolic pathways: exploring the chemical roots of systems biology (ProtoMet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Spain,Germany,Spain,Italy,Switzerland,France,France,France,United States,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2018-11-01
End date: 2023-10-31
Duration (months): 60.0
Total project cost (EUR): 2174048.28
EU funding (EUR): 2174048.28
Participants: 11
Project status: SIGNED

Understanding how prebiotic chemistry gave rise to life as we know it represents one of the greatest enduring mysteries. The complete absence of a historical record requires the collaboration of scientists from different disciplines with access to advanced tools in order to make any meaningful progress. Here, we plan to exploit this tremendous challenge to train a new generation of scientists to think big, but also to work methodically and logically alongside colleagues from academia and industry. Eight Early-Stage Researchers (ESRs) will be recruited to work in laboratories with expertise in systems chemistry, synthetic biology, microfluidics, and science philosophy to develop together a reconstituted protometabolism within compartments consisting of coacervates, vesicles, coacervate containing vesicles, and compartments etched into microfluidic chips. The underlying protometabolism will be composed of triose glycolysis and a reverse citric acid cycle and will be regulated by (metallo)peptide catalysts. Importantly, the protometabolism will support the maintenance of the compartment that houses the protocell. The ESRs that primarily focus on the construction of compartments that mimic protocellular structures will gain firsthand experience in how their formulations could be exploited as drug delivery vehicles through secondments at partner organizations. Similarly, the ESRs that develop (metallo)peptide catalysts will apply their newfound skills to the development of drug molecules through a secondment at a company that specializes in metallodrug formulations. Ultimately, by becoming experts in elucidating the chemical underpinnings of all known living cells, the ESRs will be extremely well positioned to enter a wide variety of research fields from synthetic biology to medicinal chemistry in either industry or academia.

Keywords: origins of life,prebiotic chemistry,metallopeptide,protocell
Dynamic Earth Evolution and Paleogeography through Tomographic Imaging of the Mantle (DEEP TIME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France,United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-08-01
End date: 2022-01-31
Duration (months): 78.0
Total project cost (EUR): 1438846.0
EU funding (EUR): 92626.36
Participants: 2
Project status: CLOSED

DEEP TIME will unearth a record of geological time that is buried thousands of kilometres deep. The seafloor that covers two-thirds of the earth's surface is a tiny fraction of all seafloor created during its history – the rest has sunk back into the viscous mantle. Slabs of subducted seafloor carry a record of surface history: how continents and oceans were configured over time and where their tectonic plate boundaries lay. DEEP TIME will follow former surface oceans as far back in time as the convecting mantle system will permit, by imaging subducted slabs down to the core with cutting-edge seismological techniques. Current tectonic plate reconstructions incorporate little if any of this deep structural information, which probably reaches back 300+ million years; they are based on present-day seafloor, which constrains only the past 100-150 million years. DEEP TIME will match deep slab structure to the geological surface record of subduction – volcanic arcs and other crustal slivers that stayed afloat, survived collisions, and form the world’s largest mountain belts. Integrating these two direct records of subduction, the project will * Add paleo-trenches to existing plate reconstructions and extend them 2-3 times longer into the past. * Produce a 3-D atlas of the mantle that matches subducted seafloor with paleo-oceans inferred by land geology. * Rigorously test the hypothesis of vertical slab sinking, which may yield an absolute mantle reference frame. Tomographic models and geological land records will be synthesized into quantitative and testable paleogeographic reconstructions that complement and extend existing ones, especially in paleo-oceanic areas. This is likely to transform our understanding of the earth’s physical surface environment and biosphere during Mesozoic times, as well as the formation of natural resources. It also will put observational constraints on elusive mantle rheologies. Nearly every subdiscipline of the earth sciences could benefit.

Keywords: mantle structure,seismic tomography,plate tectonic reconstructions,geology,geodynamics,continental growth,mountain belts,subducted ocean basins,paleomagnetism
Tubular Supramolecular Polymers: A new class of therapeutic polymers (TUSUPO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2021-06-30
Duration (months): 72.0
Total project cost (EUR): 1692376.0
EU funding (EUR): 1692376.0
Participants: 1
Project status: CLOSED

This research programme will establish a new class of materials and develop them into functional devices for biomedical applications. We will design tubular supramolecular polymers, supramolecular polymer brushes (SPBs), based on the self-assembly of cyclic peptide – polymer conjugates. The synergy between the cyclic peptide, which directs the formation of the SPBs and the polymer conjugate, which provides functionality, will open the route to a wealth of new functional structures. We will build on our initial work and expand our research to generate new synthetic routes for the ligation of polymers to peptides, develop new protocols for the characterisation of the materials, and establish the mechanism of supramolecular polymerisation. This research programme will open new horizons in the fundamental understanding and production of supramolecular polymers. In particular, beyond the generation of new materials, the functionality of these systems may allow the development of supramolecular living polymers, a long-standing goal in polymer chemistry that is still elusive. The functionality and versatility of the SPBs obtained in this work open the route to a wealth of applications, and we will focus on one specific target: the fabrication of drug delivery vectors. We will exploit the unique combination of features presented by this new class of polymer therapeutics, such as multiple attachment points for one or more drug(s) / targeting ligands / markers, the ability to self-disassemble into smaller and easy-to-excrete components, and an elongated shape that enables diffusion and interaction with cells more efficiently than traditional globular delivery systems. We will study the pharmacology properties of the SPBs, including their stability, toxicity, mode of cell penetration and ability to deliver a single or a combination of bioactive agent(s) (in the case of concerted mechanisms).

Keywords: living radical polymerisation,peptides
Elucidating the involvement of neutrophils in the pathogenesis of tuberculosis using a zebrafish model (MYCONEUTROPHILS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Tuberculosis has afflicted humans for about 70,000 years and continues to take a huge toll on human health. The increase of drug-resistant Mycobacterium tuberculosis and the limited effectiveness of the existing treatments make urgent a deeper understanding of its immunopathogenesis. The role of macrophages in the disease has been intensively studied, but little is known about the involvement of neutrophils. Recent findings indicate that neutrophils play crucial roles in the pathogenesis of tuberculosis that are unknown until the present. Thus, in this project I will use the recognized zebrafish-Mycobacterium marinum infection model, available in the host lab, to study the role played by neutrophils in mycobacterial infection. I propose to use this infection model combined with in vivo imaging of the interactions host-pathogen, gain and loss of gene function strategies, the use of zebrafish transgenic and mutant lines, gene expression analysis, and multitude of other techniques available in the host lab to study (1) how mycobacteria can evade neutrophil recruitment and phagocytosis, (2) what is the origin of the two functionally different neutrophil populations observed in mycobacterial infection, (3) how neutrophils can kill mycobacteria in the absence of macrophages and without any physical interaction, and (4) why neutrophils act as macrophage scavengers. The elucidation of all these questions never studied before will allow me to shed light on the involvement of neutrophils in the pathogenesis of tuberculosis, and will represent a relevant improvement in the field with biomedical implications. Moreover, it will be a crucial step in my scientific career thinking of becoming a group leader in the field of immunology and infectious diseases, since I will have the opportunity to work in a relevant biomedical question, with the support of the main experts in the field, in an unsurpassable scientific environment, and with the best facilities.

Keywords: tuberculosis,mycobacterial infection,neutrophils,involvement of neutrophils in the pathogenesis of tuberculosis,zebrafish,mycobacterium marinum infection model
CONNECTED CLERICS. BUILDING A UNIVERSAL CHURCH IN THE LATE ANTIQUE WEST (380-604 CE) (CONNEC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Austria,United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-06-30
Duration (months): 66.0
Total project cost (EUR): 1465316.0
EU funding (EUR): 1333336.0
Participants: 2
Project status: SIGNED

In 380 CE, the Emperor Theodosius (d. 395) ordered all Roman subjects to follow Catholic Christianity and limited imperial patronage to the Catholic Church. Theodosius was the last ruler to reign over a united empire. At his death the realm was divided into two halves, and by the end of Gregory the Great’s papacy (d. 604), a mosaic of independent kingdoms had replaced the western part of the empire. Yet despite the political division, during this period western clerics built a supra-regional ecclesiastical structure with substantial levels of hierarchy and cohesion. Up to the 1950s historians have largely conceived of these ecclesiastical institutions as organizations with widely accepted power. More recent scholarship, however, has revealed the social origin and fallibility of clerical authority. Nonetheless, this move away from the study of institutions has left unanswered the fundamental questions of how a ‘universal’ church was built at a time of political fragmentation, and how the transition from informal mutual aid to more formal hierarchical structures of law- and policy-making came about. With innovative methods of social inquiry we can offer new answers to these historiographical questions. Our project (CONNEC) will use social network analysis and new institutional theory to trace four processes: how clerical networks adapted to the new secular contexts, how these interactions shaped the development of ecclesiastical law, how clerics constructed and disseminated discourses that supported different structures of the church, and how networks fostered compliance and a sense of accountability among clerics. CONNEC’s use of state-of-the-art methods will be enhanced by the implementation of cutting-edge digital technologies, adapting network analysis software for late antique sources. By bringing together digital tools with qualitative textual analysis, CONNEC will provide a more nuanced understanding of a key process of world history.

Keywords: history of late antiquity,history of the christian church