Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Homology of labelled configuration spaces via spectral Lie algebra methods (HLCSSLA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: SIGNED

The goal of this project is to produce new computations of the mod p homology of labelled configuration spaces of a general manifold with labels in an arbitray spectrum. These computations have remained outstanding challenges for decades except in special cases. Recently developed techniques in stable homotopy theory, including spectral Lie algebras and synthetic homotopy theory, have proven to be useful in understanding the algebraic structure on the homology groups of labelled configuration spaces in universal cases, but are less attuned to the topology of the input manifolds. In this project, I plan to attack the problem by incorporating the homotopy-theoretic methods with approaches that take into account the geometry of labelled configuration spaces. New computations of these objects will have applications in a range of fields including stable homotopy theory, string topology, embedding calculus of manifolds, mathematical physics, and motion planning. The supervisor will be Prof. Nathalie Wahl at the department of Mathematics of the University of Copenhagen.

Keywords: configuration spaces,homology,spectral lie algebra,spectral sequence,synthetic homotopy theory,homological stability,mapping class group
Cristina Purtill, Plio Surgical (Cristina Purtill)

Framework: Horizon Europe — Innovative Europe
Programme: The European Institute of Innovation and Technology (EIT)
Theme: EU prize
Destination: EU Prize for Women Innovators
Action type: Recognition Prize
Countries involved: Ireland
Call: EIT Category (HORIZON-EIT-2023-WomenInnovatorsPrize, 2023)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: SIGNED

Founder and CEO Cristina Purtill set up Plio Surgical, a spin-out of Trinity College Dublin with the vision to address one of the most serious complications of colon cancer surgery which consists of a leakage that can occur at the site where the surgeon reconnects the healthy ends of the bowel after the tumour is removed (which is called an anastomosis). This can can lead to patients developing sepsis and requiring re-operation or stoma creation. This contributes to a decreased quality of life for patients, poor clinical outcomes, and increased costs to the healthcare systems worldwide. Plio Surgical developed an innovative implant to reduce anastomotic leakage and make it easier and safer to create an anastomosis. The implant has specially designed tissue anchors so it doesn’t use staples or sutures. Once the healing has occurred, it detaches and passes naturally leaving nothing behind in the patient. Cristina Purtill is a highly experienced professional with a rich career in the healthcare industry, spanning across various countries in Europe and USA. Cristina's career has been marked by a commitment to entrepreneurship which culminated with setting up Plio Surgical. Under Cristina’s leadership, she assembled an excellent team with significant experience in developing and bringing medical devices to market. Plio Surgical were recognised by being selected in the MedTech Innovator Accelerator in the United States out of more than 1,100 highly innovative MedTech companies worldwide. Furthermore, Plio Surgical was also won the UK/ Ireland regional competition of the EIT Health Catapult and received of the People's Choice Award in the Building Better Future of Health Challenge in 2023. In addition to her professional pursuits, Cristina is a devoted mother of three girls. She is keenly passionate about encouraging the next generation to pursue careers in technology and entrepreneurship.

Keywords: medtech innovation
Sustainable Aviation Fuel Production via High Temperature Electrolysis and an integrated Fischer-Tropsch Reactor (SAFphyre)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Netherlands,France,Switzerland,Denmark,United Kingdom,South Africa
Call: Innovative co-electrolysis systems and integration with downstream processes (HORIZON-JU-CLEANH2-2025, 2025)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 4549929.03
EU funding (EUR): 4049361.13
Participants: 7
Project status: SIGNED

Solid oxide electrolysis (SOE) is a promising technology for producing sustainable aviation fuel (SAF) via Fischer-Tropsch (FT) synthesis. Despite its advantages, such as high efficiency and waste heat utilization, challenges remain in scaling up SOE/FT integration. These include optimizing heat integration, cell performance, and energy efficiency while reducing costs. Collaboration is crucial in addressing these issues and advancing SOE/FT technology to meet the growing demand for low-carbon SAF driven by recent emission reduction targets. SAFphyre brings together a well-designed consortium of industry experts and leading researchers to tackle key challenges in co-SOE and FT. By leveraging their collective expertise in computational modeling, experimental validation, and industrial scale-up, the consortium will address critical issues in materials development, process optimization, and system integration. The industrial partners – Topsoe and Sasol – will bring in essential expertise in manufacturing, scale-up, and commercialisation, while providing a clear pathway to further develop and exploit its key results. The main aim of SAFphyre is thus to demonstrate the production of SAF using syngas produced by co-SOE technology. It will manufacture and test next generation SOE cells and combine advanced modelling and simulations with innovative numerical approaches to optimise BoP and cell design, demonstrating the potential for highly efficient and cost-effective co-SOE. Fed by the latest industrial insights on co-SOE manufacturing and FT e-fuel production, SAFphyre will address the key technical challenges for co-electrolysis integration to deliver a demonstration platform for new co-SOE technology that includes dynamic operational and scale-up strategies for large scale (100+ MW) systems, thereby lowering costs, increasing efficiency, accelerating the deployment of co-SOE and contributing to the overall sustainability of the European chemicals industry.

Keywords: solid oxide electrolysis,fischer tropsch,sustainable aviation fuel,process simulation,heat integration
non-thermal Radiation from AStrophysical jets: from theory of Plasma turbulence to Observations (RASPO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: CLOSED

Relativistic jets from Active Galactic Nuclei (AGN) and Gamma Ray Bursts (GRBs) have fascinated astronomers for decades. Despite its importance for multi-messenger astronomy, astroparticle physics, and galaxy evolution, the physics of relativistic jets is not fully understood. According to a widely accepted paradigm, relativistic jets extract the rotational energy of the black hole via electromagnetic stresses, and transport it out to large distances in the form of Poynting flux. However, we do not understand how the Poynting flux is converted into the non-thermal radiation that we observe. Since relativistic jets have huge Reynolds numbers, turbulence could naturally dissipate the magnetic energy and accelerate a population of non-thermal particles, which emit the observed radiation via synchrotron and inverse Compton cooling. Developing concrete jet emission models based on such scenario has recently become possible due to the advent of large-scale fully kinetic simulations of magnetically dominated plasma turbulence. A crucial finding of these simulations is that particles have a strong pitch angle anisotropy (namely, particles move nearly along the direction of the local magnetic field), contrary to the textbook (and ad hoc) assumption that the radiating particles in relativistic jets are isotropic. I propose a project aiming to investigate "non-thermal Radiation from AStrophysical jets: from theory of Plasma turbulence to Observations" (RASPO). In this project, I will develop models for the pitch angle and energy distribution of the radiating particles that rely on fully kinetic simulations (rather than ad hoc assumptions), and fit these model to the non-thermal spectra of AGN and GRB jets. I will study the apparent contradiction between fitting of non-thermal spectra with existing isotropic models, which suggest that the emission region is matter dominated, and theoretical expectations, which suggest that jets should be instead magnetically dominated objects.

Keywords: relativistic jets blazars gamma ray bursts non thermal radiation turbulence magnetically dominated plasmas
International cooperation for digital standardisation (INSTAR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Coordination and support actions
Countries involved: Spain,Italy,Germany,Belgium,France,Netherlands,Greece,Austria
Call: Support facility for digital standardisation and international cooperation in digital partnerships (CSA) (HORIZON-CL4-2023-HUMAN-01-CNECT, 2023)
Start date: 2024-01-01
End date: 2026-06-30
Duration (months): 30.0
Total project cost (EUR): 1780052.55
EU funding (EUR): 1498596.67
Participants: 10
Project status: SIGNED

INSTAR promotes Europe’s position as a forerunner in global standards-setting in advanced ICT technologies (eg. AI, 5G and 6G, internet protocols, IoT, cybersecurity, data, eID, quantum or DLTs) with strategic international partners. The 30-month project shapes the definition & uptake of standards in target countries, delivers studies & analyses on ICT standards, and monitors international standards in trade & cooperation agreements. INSTAR’s active and experienced ICT standardisation experts will manage a set of technology domain workstreams to build high-level standardisation frameworks, engaging key stakeholders; map standards onto a Standards Dashboard; activate high-level task forces to provide inputs; organise webinars and workshops; deliver monthly and bi-annual reports on agreements on common standards and roadmaps; monitor international standards implementation in trade and cooperation agreements. Impact: a)high-level standardisation frameworks; b)Standards Dashboard with a common vision in international fora/SDOs; c)6 High-level Task Forces (TF) to manage technology domain workstreams; d)bi-annual reports on agreements on common standards and roadmaps; e) monitoring implementation of int’l standards in trade & cooperation agreements. The strong Consortium of 10 partners, 8 countries with complimentary skills: 4 specialist consultancy SMEs, 4 RTOs, an industry association & a university, active & well regarded in the standardisation community, EU & internationally. Partners are embedded in existing SDOs and standardisation initiatives, in committees centred on the key technologies while retaining independence; have trusted relationships with stakeholders in target countries, and are experienced in supporting the development of effective standardisation policies. Engagement includes 6 task forces, 6 joint committees, 6 workshops, 6 Webinars, 1 Impact event, 2 Coordination Board meetings, 10 signed MoUs, 24 3rd party events; 1,000 engaged community members.
Deep learning analysis of imaging and metabolomic data to accelerate antibiotic discovery against antimicrobial resistance (AI4AMR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: France,Germany
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-04-01
End date: 2031-03-31
Duration (months): 72.0
Total project cost (EUR): 10968734.0
EU funding (EUR): 10968734.0
Participants: 4
Project status: SIGNED

Antimicrobial resistance (AMR) is one of the most pressing global health problems of our times. To counteract AMR, we urgently need new antibiotics, particularly with novel modes of action (MoA). However, while typical antibiotic screening pipelines can identify compounds that impair bacterial growth, they are unable to predict drug targets and MoA so must be followed up by time-consuming target identification steps. By synergizing our expertise in microbiology, genetics, advanced microscopy, metabolomics, medicinal chemistry, computational biology and artificial intelligence (AI), we propose to create a new pipeline at the forefront of the antibiotic discovery field that will be capable of informing simultaneously on the bioactivity and MoA of new antibiotic candidates. Working with seven pathogens, our improved acquisition strategies for both imaging-based high-content screening and metabolomics will generate a massive dataset of rich multidimensional phenotypes of libraries of genetic mutants and of bacteria exposed to a range of perturbants, at unprecedented scale. Deep learning analyses will then enable us to explore these massive datasets to correlate chemical-induced phenotypes to those from mutants, linking drugs to genes to elucidate the target/MoA of new drugs. This innovative pipeline will enable us to explore unique chemical spaces, including complex natural product extracts (without the need for isolation of individual components) and novel synthetic compounds. Promising candidates with novel MoA will be tested against drug-resistant clinical isolates and against a future pandemic 'pathogen X', demonstrating our pipeline as an AI-powered solution for achieving higher productivity in antibiotic discovery. AI4AMR will provide the community with a new pipeline to efficiently screen large compound libraries to identify novel antibiotics and define their MoA and target, helping directly to combat AMR.

Keywords: antibiotics,metabolomics,chemical libraries,natural products,mutant libraries,high content imaging,artificial intelligence,drug discovery
Programmable Reconfigurable Optical Transport for Efficiently offering Unconstrained Services in 6G (PROTEUS-6G)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Greece,Italy,Spain,Germany,Israel,Netherlands,Portugal,Switzerland
Call: Communication Infrastructure Technologies and Devices (HORIZON-JU-SNS-2023, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 4182601.25
EU funding (EUR): 3967251.25
Participants: 14
Project status: SIGNED

PROTEUS-6G focuses on the development of advanced packet-optical x-haul networking infrastructure, relying on novel software-programmable photonic-integrated-circuit based subsystems operated under an intelligent software management system, capable of simplifying and optimizing network operations and supporting future ultra-high capacity, low-latency and energy-efficient 6G cellular and cell-free MIMO radio access networks. The targeted innovations will enable efficient utilisation of packet and optical resources (spectral subcarriers and spatial lanes), realizing the vision of flexible functional splits (FFSs), adapting the fronthaul, under dynamically customizable operational conditions, to the network demands, for varying distribution of users, traffic demands and use-cases. To implement the 6G optical-enabled radio-access network, the consortium will develop ultra-low energy (low-pJ/bit), ultra-high capacity (0.8 Tb/s) and fast-reconfigurable (sub-ms) software-programmable solutions (i.e. transceivers, multiplexers and fast optical switches integrating tuneable lasers/filters) based on novel photonic processing/switching schemes, to be reconfigured by an intelligent control plane optimizing the utilization of resources across the front-/mid-/back-haul continuum and reducing unnecessary opto-electronic transitions, thus collectively improving performance while minimizing the environmental impact. The PROTEUS-6G consortium covers the entire value-chain of industry/academia organizations focusing on implementing wireless-optical connectivity solutions. The participating experts possess demonstrated expertise re delivering on their promises as indicated by their research track record and exploitation activities towards commercialization of new products and contributions to standards. Their collective development of the targeted innovations is going to reenforce the European leadership in 6G networks thus paving the way for prosperity of Europe’s economy and society.

Keywords: 6g fronthaul,flexible functional split,optical enabled radio systems,programmable optical transceivers,optical switching,inteligent control,energy efficiency
One Archaeological Science in the BEMME region (OneArchSci)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Panel: Social Sciences and Humanities
Countries involved: Cyprus
Call: ERA Chairs (HORIZON-WIDERA-2023-TALENTS-01, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2498572.5
EU funding (EUR): 2498572.5
Participants: 1
Project status: SIGNED

OneArchSci aims to attract an innovative researcher to lead, integrate, expand and thereby significantly strengthen the archaeological science group at the Cyprus Institute. It will spearhead a One Archaeological Science approach to integrate the currently fragmented field, and position the research team as the regional leader in the Balkans, Eastern Mediterranean and the Middle East (BEMME), a region that from the Bronze Age through to the Ottoman period has been culturally closely connected, while preserving distinct identities of its peoples. Concrete steps will be taken to cross sectorial boundaries, linking academic research with government agencies, NGOs and SMEs, contributing to multiple impacts on a societal level. Over a five-year period, Professor Patrick Degryse, an outstanding researcher and research manager from KU Leuven, Europe’s most successful university in terms of Horizon Europe grant income, will work with the existing team in Cyprus to establish a new formally incorporated research facility at the Cyprus Institute. We will recruit a rising star as long-term New Team Leader, supported by a team of younger researchers to enable this step change. The collaboration with KU Leuven will continue beyond the project, offering long-term opportunities for brain circulation, research and educational programme development

Keywords: archaeological science,community of practice
PArtial REbreathing for Migraine with Aura (PAREMA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 2115824.25
EU funding (EUR): 1481076.0
Participants: 1
Project status: CLOSED

Migraine with aura (MA) affects 4% of the global population, causing severe attacks that strongly impact patients’ quality of life. Currently available treatments are often ineffective, contraindicated or prone to side effects, causing 74% of migraine patients to be unsatisfied with their current treatment. This indicates a large unmet clinical need and a significant commercial potential. The Rehaler medical device is a unique, patented, non-drug MA treatment that effectively relieves or aborts a high percentage of migraine attacks by modulating CO2 and O2 levels in the central nervous system. The device has a unique commercial advantage by combining 1) A high treatment effect, 2) A low risk profile, and 3) Simplicity, compactness and affordability. To pave the way for regulatory approval, market launch and wide-scale adoption, we will carry out a large-scale clinical trial to collect gold-standard safety and performance data, while expanding our company team and production capacity.

Keywords: neurology