Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development and Validation of ‘findtb’, A Novel Digital Tool for Tuberculosis Triage in Children - Using Innovative Methodologies and an Interdisciplinary Approach (FIND-TB)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1999788.0
EU funding (EUR): 1999788.0
Participants: 1
Project status: SIGNED

About 50-65% of children suffering from tuberculosis (TB) across all age groups are never detected. This contributes to the 250,000 deaths from TB in children annually, making the disease one of the top ten killers of children under the age of five. To improve TB detection in children and reduce TB-related morbidity and mortality, novel diagnostic tests are urgently needed. The Find-TB project aims to address this urgent need by improving case finding at all levels of care in resource-limited, high TB burden settings through the development and validation of an innovative, digital TB triage tool that provides individualized TB disease risk predictions coupled with clinical recommendations to guide next steps of care. The project will capitalize on digital and scientific innovations that have been successfully applied to the COVID-19 pandemic. Starting with large, existing geographically and demographically representative data sets, my team and I will develop and validate two predictive models using highly innovative data science methods (machine learning and Bayesian techniques). An app for use by health personnel at all levels of the health care system will be developed for the best performing model. To maximize the app’s implementation potential, I will engage key stakeholders to assess preferences, acceptability, and feasibility prior to and throughout app development. Furthermore, I will apply human-centered design principles. We will then evaluate the design-locked digital tool in a real-world triage use case in a prospective, cross-sectional diagnostic accuracy study. A cost-effectiveness analysis of population level impact will round out a dossier that will inform a WHO review. This efficient, effective, and scalable digital tool for TB triage of children in resource-limited settings is expected to improve TB diagnosis on an individual-level and thus TB-related morbidity and mortality and on population-level is likely to improve TB control.

Keywords: tuberculosis,diagnostics,digital,global health
EFFICIENT AND NOVEL WASTE STREAMS CO-PROCESSING TO OBTAIN BIO-BASED SOLUTIONS FOR PACKAGING AND AGRICULTURAL SECTORS (ELLIPSE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Spain,Belgium,Portugal,Italy,Croatia,Netherlands,Austria,Ireland
Call: Co-processing of mixed bio-based waste streams (HORIZON-JU-CBE-2022, 2022)
Start date: 2023-05-01
End date: 2027-04-30
Duration (months): 48.0
Total project cost (EUR): 7113497.5
EU funding (EUR): 5509655.5
Participants: 14
Project status: SIGNED

ELLIPSE project will address the valorisation of two heterogeneous waste streams generated in significant amounts in Europe, slaughterhouse waste (bellygrass) and paper and pulp sludge, to produce cost-efficient PHAs for agricultural and packaging sectors, by the co-processing with other organic waste streams such as glycerol from the biodiesel industry and sludge from the dairy industry. The integration of these waste streams as biorefinery feedstocks will allow reducing the volumes of waste destined to landfill or anaerobic digestion, opening new avenues for platform chemicals and bioplastics production while creating additional revenue for the related industries generating the waste, with added advantages of water recycling, decreased soil degradation, groundwater pollution and methane emissions. The selected ELLIPSE feedstocks are locally available and renewable leading to close to 100% renewably sourced personal care packaging and agricultural products. ELLIPSE project will be able to cope with at least 100 tonnes of slaughterhouse waste and 20 tons of wastewater sludge derived from pulp and paper industry. The ELLIPSE technology will impact in the European bioeconomy by valorising 20,000 tons of rumen content waste and 50,000 tons of paper sludge per year. ELLIPSE has a multi-actor approach including all the relevant actors in the bio-based system from the waste stream production and management (GG and HEPA) to technology developers (AIMPLAS, UNIVR, CARTIF, BEST) and industrial actors, both SMEs (BIOT, BIOMI, ZER0-E, HP) and bigger companies (BBEPP, NVMT), plus the expertise of ENCO for the market development perspective. ZER0-E will contribute with the end-user and consumer’s perspective so that all inputs from the relevant actors are taken into account.

Keywords: pha,bioprocess,waste,valorization,fermentation,packaging,biofertilizers,coatings,nutrient recovery,recycling
Managing local and global externalities from growth (EXTGROW)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499740.0
EU funding (EUR): 1499740.0
Participants: 1
Project status: SIGNED

The burden of local and global externalities from growth - such as pollution, congestion and climate change - falls mainly on the poorest across and within countries. EXTGROW will break new ground by offering novel insights into the magnitude and distribution of key externalities in low income countries, and the design of policies that balance the dual imperatives of shielding vulnerable populations and continued growth. It is distinctive in five ways: (1) georeferenced data from innovative sources; (2) frontier spatial equilibrium modelling and econometric methods; (3) aggregate effects of externalities at scale; (4) informing transport, trade and social protection policy design; (5) focus on inequality. The proposed research comprises six projects across two themes which consider respectively the management of local and global externalities. The first theme considers how local externalities alter assessments of the aggregate and distributional impacts of trade facilitation, which is key for the design of transport and trade policies. The first project will examine how traffic pollution in Pakistan influences estimates of the gains from road building. The second assesses whether banning trade in waste products improves welfare when externalities from disposal are heterogeneous across space. The third estimates the impacts of public transit in Tanzania for alleviating congestion costs across income groups. The second theme studies how vulnerable populations respond to the global externalities from climate change and how policy can support these adaptive adjustments. The fourth project will draw on the rollout of a big-push anti-poverty program in Bangladesh to understand whether it can shield beneficiaries from climate shocks. The fifth studies how targeting of public adaptation investments in Pakistan should respond to firms’ private adaptation. The sixth will test whether sovereign natural disaster insurance in the Philippines induces moral hazard in adaptation.

Keywords: environment
Exploiting Nanopore sequencing to discover what microbes eat (NanoEat)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 1455274.0
EU funding (EUR): 1455274.0
Participants: 1
Project status: SIGNED

MicMicrobial communities play a vital role in most processes in the biosphere and are essential for solving present and future environmental challenges. Examples include the impact of the human microbiome on health and disease, the discovery of new antibiotics, and turning waste products into valuables. In the past 10 years, new DNA sequencing-based methods have revolutionized our access to the genomes of microbial communities and have sparked an explosion of new fundamental discoveries based on genomic evidence. However, despite the fundamental discoveries enabled by new methods in the past decade, we are far from having a meaningful genomic representation of the tree of life - and we are even further away from understanding how microbes realize their genomic potential in complex environments. This is underlined by the fact that the current microbial genome databases contain genomic information on 47,894 prokaryotic species, while the most conservative analysis estimates millions of different species in nature. The NanoEat project will enable the next generation of large-scale studies in microbial communities to answer the fundamental questions of who is there and what do they eat. In nature, most microbes modify their DNA in highly specific combinations, either as a defense system against viruses or to regulate activity. In NanoEat we will exploit this feature using the raw Nanopore sequencing signal that, in principle, enables discovery of any type of modified DNA. By developing new machine learning frameworks that can identify these species-specific modification patterns we can utilize this novel feature to supercharge recovery of individual microbial genomes from complex communities. Furthermore, by supplying synthetic nucleotides, that can be detected by Nanopore sequencing, we hypothesize that it is possible to estimate how microbes grow, by using the incorporation rate of these synthetic nucleotides to estimate replication in complex communities at scale.
In situ structural basis of human axonopathies (cryoNERVE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1986750.0
EU funding (EUR): 1986750.0
Participants: 1
Project status: SIGNED

Myelinated axons propagate action potentials across otherwise unsurmountable distances. The overarching hypothesis of the cryoNERVE project is that membrane morphology crucially determines axonal health and function. Mutations in genes coding for membrane-shaping proteins are the major cause of familial axonopathies like hereditary spastic paraplegia (HSP) and Charcot-Marie-Tooth (CMT) disease. However, current techniques lack the resolution to ascertain the functions of these proteins and their pathological dysfunction within native nerves. At the same time, the highly specialized architecture of axons and their delicate interplay with glia can only be studied in situ. I have shown how cryo-electron tomography (cryo-ET) reveals the structural basis of neuronal function and disease within intact cells. However, cryo-ET imaging of tissues remains a major challenge. In cryoNERVE, we will develop cryo-ET workflows to image native nerve tissue at unprecedented resolution. We will build on these advances to study the function of HSP and CMT proteins within truly physiological environments. Specifically, we will investigate (i) how these proteins shape axonal organelles and their cross-talk, (ii) the mechanisms allowing myelin sheath formation and neuron-glia communication, and (iii) the alterations introduced by axonopathy-causing mutants. Lastly, we will pioneer the first cryo-ET analyses of vitrified human tissues. Frustratingly, peripheral nerve biopsies from axonopathy patients often cannot be diagnosed with existing methods. We will examine patient biopsies at molecular resolution, and capitalize on our findings in flies and mice to reveal hitherto obscured pathological abnormalities. Thus, cryoNERVE will provide a holistic molecular and structural basis of human axonopathies like HSP and CMT, pave the way for high-resolution analyses of native human tissues and explore the potential of cryo-ET as a diagnostic tool with nanometric precision.

Keywords: cryo electron tomography cryo focused ion beam milling endoplasmic reticulum mitochondria myelin membrane morphology axonopathy hereditary spastic paraplegia charcot marie tooth disease
Green Additive Manufacturing through Innovative Beam Shaping and Process Monitoring (InShaPe)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Photonics, Made in Europe (co-programmed)
Countries involved: Germany,Netherlands,France,Italy,Spain,Sweden,Israel,Slovenia
Call: Laser-based technologies for green manufacturing (Photonics - Made in Europe Partnerships) (RIA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-06-01
End date: 2025-05-31
Duration (months): 36.0
Total project cost (EUR): 7216933.0
EU funding (EUR): 7216931.25
Participants: 11
Project status: CLOSED

The overall aim of the InShaPe project is to develop and demonstrate in four different industrial use cases (aerospace, energy, space and industrial goods) a novel first-time-right Powder Bed Fusion Process of Metals using Laser Beam (PBF-LB/M). The process will be underpinned by two technical innovations: (i) a first-of-a-kind AI-enhanced optical beam shaping module that enables the flexible adaptation of laser beam shapes tailored to the material/geometry of the printed parts; and (ii) a novel multispectral in-line process monitoring and control system application. It is expected that InShaPe will disrupt the manufacturing sector by helping to turn PBF-LB/M from a niche high-potential technology into a mainstream manufacturing technology outperforming traditional methods such as die casting when it comes to the precision of manufacturing parts, treatment of novel super-materials and sustainability. At the same time the InShaPe innovation is expected to keep pace with traditional manufacturing methods when it comes to cost-per-part economics and agile and large-scale production volumes. The KPIs to be reached in the project are: 7 times higher build rate, over 50% lower cost, 60% less energy use and 30% less scrap as compared to current best-in-class PBF-LB/M. Furthermore, the project will demonstrate how AI-based solutions can be practically deployed to deliver advanced manufacturing strategies whilst complying with current ethical standards and user expectations. InShaPe is targeting the rapidly growing global metal fusion additive manufacturing market which is estimated to be worth EUR 6.92 billion annually. In terms of the long-term impact, the successful deployment of the InShaPe technologies is expected to reinforce the European PBF-LB/M manufacturing sector's international reputation as a leading supplier of highly complex parts, and help stakeholders set new best-in-class standards for digital, green, and agile laser-based production methods.

Keywords: powder bed fusion of metals using laser beams multi spectral in line process monitoring and control system flexible adaptation of laser beam shapes
Defining the origin of Barrett’s oesophagus by exploring a submucosal gland stem cell model (ORIBAR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: TERMINATED

Esophageal adenocarcinoma is the most rapidly increasing form of cancer in the Western world characterized by short survival times. Its precursor lesion is Barrett’s oesophagus, which is present long before oesophageal adenocarcinoma arises. This offers an opportunity for prevention. However, the cell of origin of Barrett’s oesophagus is unknown. This represents a huge knowledge gap and impairs the development of preventative and curative therapies. My research has shown homeobox transcription factor HOXA13 is expressed in both Barrett’s oesophagus and in a fraction of oesophageal submucosal gland cells, but not in differentiated epithelial cells of the oesophagus or stomach. The submucosal glands have been proven to have positional and mutational kinship with Barrett's oesophagus. Therefore, they likely contain its cell of origin. Currently, the only models with oesophageal submucosal gland cells are large laboratory animals. These don't contain human cells, are impractical, costly and unethical in their use. Therefore, I propose to establish and validate the first human, 2D, organoid based, model of these glands. I propose to test if submucosal glands contain the (HOXA13+) tissue specific stem cell of Barrett's oesophagus by employing single cell culture and single cell visualisation techniques. If proven, the resulting identification of the cell of origin of Barrett’s oesophagus would open a clear path to understanding mucosal plasticity and early stage oesophageal carcinogenesis. I propose to elucidate the characteristics of this cell of origin and identify which signaling pathways mediate the emergence of Barrett’s oesophagus. The proposed host group of Prof. Krishnadath is well-positioned for executing this project due to their access to relevant tissues and experience with handling submucosal glands, organoid technology and Barrett’s oesophagus experimental models. The results and experience gained will be instrumental for my further scientific career.

Keywords: barrett s metaplasia hox transcription factors carcinogenesis gastroenterology experimental medicine
Real-time growth studies of high-entropy alloy thin films: phase formation and stress evolution (GREAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

This project aims to gain physical knowledge on the mechanisms taking place during the early nucleation and growth stages of high-entropy alloy (HEA) and high-entropy nitride (HEN) thin films, hitherto only partly investigated by theoretical studies. The proposed experimental investigation is a unique, original approach that will rely on both the kinetics and the reactivity of the thin film growth process and will be achieved, for the first time in HEA/HEN films, using in situ and real-time electrical (sheet resistance) and optical (wafer curvature) nanoscale diagnostics, the latter being also capable to provide reliable information on the intrinsic stress of the produced material. Ex situ post-growth microstructural evaluation will be also considered, as well as the film synthesis conditions prevailing on their phase formation and mechanical properties. Two HEA that find applications in areas of importance for society will be studied: the CoCrFeMnNi and MoNbTaVW, which are archetypes of fcc- and bcc-forming systems, respectively. The former is the most studied HEA, known for its outstanding mechanical properties even in cryogenic environments, whereas the latter is an advanced refractory alloy with high-temperature strength and stability. This postdoctoral fellowship will be carried out by the applicant Felipe Cemin under the supervision of Prof. Gregory Abadias at Pprime Institute (host), CNRS/University of Poitiers/ISAE-ENSMA (Poitiers, France).

Keywords: thin films,nucleation and growth,high entropy alloys,high entropy nitrides,intrinsic stress,magnetron sputtering