Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
foodigIT: computational FOOD science and DIGItal Transformation ERA Chair programme (foodigIT)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Panel: Life Sciences
Countries involved: Greece
Call: ERA Chairs (HORIZON-WIDERA-2023-TALENTS-01, 2023)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 2457714.92
EU funding (EUR): 2457714.92
Participants: 1
Project status: SIGNED

The EU agri-food industry is facing major challenges related to Food Security, Safety and Sustainability. European R&I actors can significantly contribute to addressing these challenges and support competiveness of EU food sector. The Aristotle University of Thessaloniki (AUTh), the largest university in Greece is widely recognised as an excellent food science R&I centre. A SWOT analysis reveals that due to the fragmentation of food research across different schools, the huge R&I potential of AUTh is not yet fully exploited, hampering progress in research excellence and talent attractiveness. In line with the “new ERA for Research and Innovation”, the European Green Deal and the EU4Digital strategy, at the heart of this proposal is the ambitious vision to establish the computational food science and digital transformation (foodigIT) Centre at AUTh. Under the guidance of a distinguished ERA Chair foodigIT aims to bridge food science across AUTh and R&I excellence by integrating current food research with data science cutting-edge digital tools and Information Technology (IT) solutions. This integration will attract top-tier talents and act as a transformative force boosting research and infrastructure synergy across AUTh. The foodigIT Centre is also poised to be a cornerstone for reshaping the relationship between academia and society through the creation of foodigITeco, a new Innovation and Knowledge Transfer ecosystem based on an extensive partnership network with R&I organisations, food industry federations, regulators/competent authorities and consumer associations. foodigITeco will transfer cutting-edge research results and knowledge from academia to the food industry, but also act as a conduit for industry needs, identifying challenges and requirements directly from the food sector and integrating them into AUTh's education programme. Overall, foodigIT will enhance AUTh’s visibility and competitiveness in the European Research Area.

Keywords: computational food science,digital transformation,food safety,food microbiology,risk management,big data,it tools
CO-CREATIVE IMPROVED UNDERSTANDING AND AWARENESS OF MULTI-HAZARD RISKS FOR DISASTER RESILIENT SOCIETY (C2IMPRESS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Disaster-Resilient Society for Europe
Action type: Research and Innovation actions
Countries involved: Türkiye,France,Portugal,Greece,Spain,Australia,United Kingdom
Call: Improved understanding of risk exposure and its public awareness in areas exposed to multi-hazards (HORIZON-CL3-2021-DRS-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 4175836.25
EU funding (EUR): 4175836.25
Participants: 17
Project status: SIGNED

There is a lack of data, understanding and awareness in Europe and in the world of compound weather and climate extremes. Insufficient governance function also affect the related vulnerability, risk and resilience of people, communities and places. The C2IMPRESS project aims to bring a radical paradigm shift to disaster and hazard research and innovation by moving away from traditional ‘hazard centric’ approach/ framework to a novel ‘place and people’ centred integrated multi-hazard risk and resilient assessment framework. Guided by this framework, the C2IMPRESS project aims to offer an ensemble of innovative revolutionary models, methods, frameworks, tools and technologies that are holistic and robust enough to provide appropriate fine-grained spatio-temporal qualitative and quantitative data, locally appropriate solutions, better prediction with lower uncertainty on risks of single or multiple hazards stemming from extreme weather events like floods, wildfires etc. under different climate change scenarios. Breakthrough innovations from C2IMPRESS project will be System-of-Systems for Multi-Hazard Risk Intelligence Network (SoS4MHRIN) platform (supported by the robust Earth System Dynamic Intelligence (ESDI) and Information Physical Artificial Intelligence (IPAI)), innovative Agent Based Model, polycentric risk governance, multi-actor decision support microservices and a suite of citizen engagement technologies and tools as well as novel co-design and co-creation approach for socio-technical innovations, knowledge production and validation to empower citizens and society with climate actions for a sustainable transition to a just risk resilient society. With these social and technical innovations -as novel processes and products- the C2IMPRESS project will provide better understanding and public awareness on multi-hazard risks, the associated multidimensional impacts, vulnerabilities and resilience of extreme weather events in 4 case study areas in Europe.

Keywords: disaster risk reductionand response,system dynamic models,agent based models,artificial intelligence,decision support system,citizen science,integrated disaster risk and resilience framework
Hyper-targeting CAR NK cells from induced pluripotent stem cells for novel off-the-shelf anti-tumor therapies (HyperTargIPS-NK)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden,Germany,Denmark
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-04-01
End date: 2026-03-31
Duration (months): 36.0
Total project cost (EUR): 3798713.75
EU funding (EUR): 3798713.75
Participants: 7
Project status: SIGNED

The HyperTargIPS-NK project aims to combine novel technologies from three research laboratories and a stem cell company to develop a revolutionary therapeutic modality for patients with devastating refractory malignancies. The treatment we propose is based on allogenic transplantation of induced pluripotent stem (iPS) cell-derived natural killer (NK) cells, genetically modified to a hyperactive state to ensure high potency NK cell targeting and destruction of tumor cells. CAR NK-based cancer treatment is an extremely promising new therapeutic avenue. However, the full potential of CAR NK therapies will only be achieved when an off-the-shelf product is rapidly accessible to patients in need. IPS with its unlimited expansion potential is the ideal cell source for NK-based products, however, improved efficiencies of NK cell production, suitably activated status, and resistance to immune suppression would need to be achieved. We have several breakthrough technologies to address these issues with 1) a novel iPS cell differentiation system based on our newly identified metabolic regulators that can be easily scaled to generate billions of functional NK cells, 2) identified and validated several novel and state-of-the-art CAR, non-CAR and TRUCK based regulators of NK activation to elicit the hyper activated NK cell state and prolonging NK survival, and 3) improved NK response to tumors via tumor microenvironment remodeling. We will target the NK cells towards three life-threatening cancers for which novel treatment options are urgently needed as they are considered among the most lethal cancers; i.e. Pancreatic cancer, Glioblastoma, and Acute Myeloid leukemia (AML). Our iPS culture system, NK activation systems, and gene editing systems, have already been designed towards GMP compatibility. Taken together, these advances ensure that once this study is successful, our Hyper-Targ-IPS-NK cells are poised for rapid translation towards the clinic with our industrial partner.

Keywords: car nk cells,induced pluripotent stem cells,hematopoietic development,genetic modification,cancer
GREEN NUDGEs for sustainable FORESTry and AGRIcultural practices post 2027 (ForestAgriGreenNudge)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: France,Sweden,Poland,Portugal,Lithuania,United Kingdom,Greece,Spain,Serbia,Finland,Slovenia,Tunisia
Call: Towards CAP post 2027: evidence on nudging farmers to leverage more sustainable practices and behaviours (HORIZON-CL6-2023-GOVERNANCE-01, 2023)
Start date: 2024-11-01
End date: 2028-04-30
Duration (months): 42.0
Total project cost (EUR): 2615435.0
EU funding (EUR): 2615435.0
Participants: 16
Project status: SIGNED

Behavioural and cognitive biases reduce the ability of decision makers to adopt the best solutions among the alternatives available. Borrowed from pre-existing knowledge in psychology on priming, “nudges” are defined as gentle interventions in a decision maker’s choice architecture (default choice, information, presentation, framing etc.), which enhance the likelihood of optimal choices. ForestAgriGreenNudges will first review initiatives and projects which explicitly or implicitly use Green Nudges to promote the use of sustainable practices in farming and forestry. It will then assess each type of nudge according to two types of criteria: 1) Criteria associated with efficacy in promoting the use of the desired practices over a sufficiently long period and 2) Criteria dictated by ethics and good practice principles (transparency, nudgee awareness, participation/self-regulation, actor-specificity, etc.) that guarantee the quality of the implementation process. Nudges will then be tested in the field and assessed on a grid, reflecting the desiderata of efficacy and implementation quality. The set of successful nudges will be enriched by innovative nudges based on information regarding attitudes and strategies of actors along the entire value chain. The resulting set of nudges together with their corresponding implementation guidelines, and the business models and market conditions which favor their application in agroforestry will be collected on an online tool (iNUDGE Academy) whose target audience will include policy makers, wholesalers, retailers, farmers and foresters. The tool will associate each nudge with implementation rules, possible domains of application and possible risks in terms of efficacy/good practice tradeoffs. Diffusion of the results among farming and forestry experts, policy makers, and actors along the value chain will maximise the impact of the project, enhancing the adoption of sustainable practices in the farm and in the forest.

Keywords: green nudges sustainable practices green transition behavioural biaises
Neutrino flavor Transformations in dense Astrophysical Environments (NeuTrAE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

This project NeuTrAE is aimed to advance our understanding on lingering puzzles on the flavor evolution of neutrinos and their implication in particle and nuclear astrophysics. Neutrinos are characterized by their flavors that can change as they propagate in a phenomenon known as neutrino flavor oscillations. The oscillations in vacuum and ordinary matter are well understood and confirmed by several experiments. Astrophysical compact objects, such as core-collapse supernovae and the violent merger event of two neutron stars or a neutron star and a black hole, are profuse sources of neutrinos. In those astrophysical environments the neutrino flux becomes so intense that the flavor interference of neutrinos with each other has to be taken into account. This non-linear effect coupling neutrinos propagating in different directions and with different energies is known as collective neutrino oscillations. Accounting for the collective neutrino oscillations in simulations of astrophysical environments requires a quantum kinetic transport. It remains a tremendous challenge due to the high-dimensionality of the problem and the vastly different scales for flavor and hydrodynamical evolution. The impact of neutrino flavor transitions on those compact objects remains elusive without efficient and sophisticated treatments. I propose the project NeuTrAE providing a pipeline to study the impact of collective neutrino oscillations in astrophysical environments. It consists of three steps: performing neutrino quantum kinetic simulations, developing numerically effective schemes that can be incorporated in state-of-the art hydrodynamical simulations, and assessing the impact of neutrino flavor transformations on heavy element nucleosynthesis and its electromagnetic signatures. NeuTrAE will also commit to significant advance on dynamical evolution of astrophysical compact objects.

Keywords: neutrino oscillations nucleosynthesis core collapse supernovae neutron star mergers quantum kinetic transport
A hybrid atom-photon-phonon quantum processor (HAPPQP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: CLOSED

Many quantum information processing tasks were first demonstrated with neutral atoms and ions. With improving capabilities of nanofabrication, a growing number of artificial systems have also shown significant potential in this area and have often even surpassed the early existing systems in their performance and potential for applications. One of these new quantum systems is the optomechanical resonator, consisting of an optical cavity, coupled through the radiation pressure force to a mechanical oscillator. When cooled to the ground state, the mechanical mode can exhibit quantum behavior and be used to process quantum information. Limited by relatively weak photon-phonon coupling, this process is typically probabilistic. In this proposal, we will include a strong non- linearity in order to facilitate a deterministic manipulation of phonons. We will realize this by introducing a single trapped neutral atom, forming a hybrid atom-photon-phonon system. The single atom will be trapped in close proximity to the optomechanical resonator and will strongly couple to the optical mode. As a first demonstration, we will realize a photon blockade effect, which will allow only one photon to enter the cavity at once, prohibiting any multi-phonon generation. This will be verified by a thermal phonon mediated Rabi oscillation experiment. Details of the technique, as well as additional experiments, are discussed in the proposal. The successful completion of these experiments will have a major impact on quantum physics. It represents a milestone towards a fully controllable atom-photon-phonon hybrid quantum system. While the project is ambitious and very competitive, it is just within experimental reach when combining several cutting edge experimental techniques. The experienced researcher Yong Yu is in a unique position to realize this project given his cold atom and quantum optics background, which matches up perfectly with the optomechanics expertise at the host group at TUD.
Hypnodelic therapy: the benefits of hypnosis know-hows for psychedelic therapy (Hypnodelic)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: SIGNED

In recent years we have witnessed a renewed interest in psychedelic-assisted psychotherapy (PAP). The psychedelic compound ketamine, a N-methyl-D-aspartate glutamate receptor antagonist, shows potential for the treatment of depression and addiction. Key psychological mechanisms underlying these effects of PAP are the suggestions by the therapists and psychedelic-induced mystical experiences. Currently, the mechanism of suggestibility in PAP is receiving more attention as it is hypothesized that all psychedelics increase suggestibility – a topic that so far has been studied mostly in the field of hypnosis research. At a neurobiological level, the predictive processing framework suggests that ketamine induces its effects by disrupting the brain’s predictive functioning. In the context of the renaissance of psychedelic research, this project proposes to leverage the practical know-how on suggestibility from hypnosis research to investigate the intriguing interplay between suggestibility, hypnotic suggestions, and the psychedelic experience within the predictive processing framework. Our study has 4 aims: 1) assess suggestibility under ketamine; 2) assess hypnotic suggestions’ impact on the phenomenology of the psychedelic experience; 3) assess if a hypnosis- and ketamine-induced mystical experience leads to improved mental well-being, and 4) validate the predictive processing framework. We will conduct a crossover randomized double-blind placebo-controlled study with a 1-month follow-up, including 36 healthy participants and 2 conditions: Hypnodelic (ketamine + hypnotic suggestions) and Hypnocebo (placebo + hypnotic suggestions). We will measure suggestibility, mystical experience, and predictive processing through quantitative, qualitative and neurophysiological analyses. This groundbreaking study has interdisciplinary translational potential, offering insights into therapeutic applications of hypnosis and psychedelics and paving the way for new clinical applications.

Keywords: hypnosis,psychedelics,ketamine,suggestion,suggestibility,phenomenology,electroencephalography
Three Generations of Digital Human Rights (DigitalHRGeneration3)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The proposed research program explores different strategies developed in the digital age within and outside international human rights law to respond to new needs, interests, risks and challenges brought about by transition of inter-personal interactions, social activities and regulatory schemes from offline to online environments. It investigates the development in recent years of three generations of digital human rights: adaptation of existing rights and their manner of application to online environments (e.g., online privacy), the creation of new digital rights (e.g., right to access the Internet) and the introduction of new rights and duty holders (e.g., virtual persons and online platforms exercising quasi-sovereign power), as well as the development of alternative protection avenues based on private ordering, including rights by design and community standards, Internet governance and multi-stakeholder arrangements. The ERC project will examine these paradigmatic normative, institutional and theoretical developments, and the policy choices behind them from five methodological perspectives: (1) historical study of the evolution of digital human rights and of choices made by norm-entrepreneurs and law-makers between different protection frameworks; (2) analytical study of protection gaps, overlaps and conflicts across traditional and digital human rights and alternative arrangements; (3) comparative study juxtaposing developments in the field of digital human rights against analogous development in international human rights law, with a view to identifying paradigms of normative and institutional change; (4) empirical analysis through interviews of the perceived effectiveness and legitimacy in the eyes of stakeholders of the said developments ; (5) Evaluation of the developments under theories of rights, global governance, business ethics and corporate responsibility and rational choice.