Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
How Bone Adapts to Heavy Weight? Bone Morphological and Microanatomical Adaptation to the Mechanical Constraints Imposed by Graviportality (GRAVIBONE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2023-03-31
Duration (months): 72.0
Total project cost (EUR): 1082450.0
EU funding (EUR): 1082450.0
Participants: 2
Project status: SIGNED

Heavy animals, said to be graviportal, are under strong mechanical constraints. Their skeleton, notably their limb bones, show convergent morpho-functional adaptations that surprisingly remain very poorly studied. Understanding the convergent and specific adaptations of bone to weight bearing in taxa with various morphologies, sizes, habitats and locomotor behaviours is essential to understand how bone responds to biomechanical constraints. In palaeontology, it will allow determining how giant fossil animals could move and support their weight. The study of graviportality provides an ideal case-study to analyse form-function relationship in a macro-evolutionary context. GRAVIBONE proposes a broad and modern comparative investigation of the biomechanical adaptations of the outer and inner bone anatomy of long bones observable in different modern and fossil taxa that have converged on graviportality. It combines various approaches using recently developed powerful methods and tools (notably the innovative integration of the whole 3D external and internal bone anatomy in biomechanical modelling) and uses these in an explicit phylogenetic context. Characterizing the various adaptive traits observed in extant taxa and understanding the link between specific isolated microanatomical, morphological and mechanical parameters will enable to: a) define degrees/types of adaptations to graviportality, b) make palaeoecological and paleofunctional inferences, and c) explain adaptations to graviportality in amniote evolutionary history. This new and highly integrative approach will increase our knowledge on the adaptation of the vertebrate skeleton and thereby of the organisms, to environmental demands.

Keywords: functional anatomy,bone adaptation
Time-domain Gibbs sampling: From bits to inflationary gravitational waves (Bits2Cosmology)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Norway
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2023-09-30
Duration (months): 66.0
Total project cost (EUR): 1999205.0
EU funding (EUR): 1999205.0
Participants: 1
Project status: SIGNED

The detection of primordial gravity waves created during the Big Bang ranks among the greatest potential intellectual achievements in modern science. During the last few decades, the instrumental progress necessary to achieve this has been nothing short of breathtaking, and we today are able to measure the microwave sky with better than one-in-a-million precision. However, from the latest ultra-sensitive experiments such as BICEP2 and Planck, it is clear that instrumental sensitivity alone will not be sufficient to make a robust detection of gravitational waves. Contamination in the form of astrophysical radiation from the Milky Way, for instance thermal dust and synchrotron radiation, obscures the cosmological signal by orders of magnitude. Even more critically, though, are second-order interactions between this radiation and the instrument characterization itself that lead to a highly non-linear and complicated problem. I propose a ground-breaking solution to this problem that allows for joint estimation of cosmological parameters, astrophysical components, and instrument specifications. The engine of this method is called Gibbs sampling, which I have already applied extremely successfully to basic CMB component separation. The new and ciritical step is to apply this method to raw time-ordered observations observed directly by the instrument, as opposed to pre-processed frequency maps. While representing a ~100-fold increase in input data volume, this step is unavoidable in order to break through the current foreground-induced systematics floor. I will apply this method to the best currently available and future data sets (WMAP, Planck, SPIDER and LiteBIRD), and thereby derive the world's tightest constraint on the amplitude of inflationary gravitational waves. Additionally, the resulting ancillary science in the form of robust cosmological parameters and astrophysical component maps will represent the state-of-the-art in observational cosmology in years to come.

Keywords: cosmic microwave background,gravitational waves,inflation,galactic radiation,modelling,instrumental effects,statistical techniques,bayesian analysis
Proactive Operational Intelligence Cybersecurity Platform for the Financial Services Industry (REDSENTRY)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Spain
Call: Engaging SMEs in security research and development (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-07-01
End date: 2017-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

REDSENTRY aims to provide a flexible, scalable and open solution to the ever-changing threat landscape faced by the financial services sector. The threats faced by the financial services industry are varied and constantly evolving and cybercrime is the 2nd most reported type of crime by financial institutions according to PWC. The potential impact of cybersecurity incidents is tremendous as the sector accounts for €731 billion (5.9%) of the EU’s total GVA (Gross Value Added) and employs 6.4 million people. The size, potential for monetary gain and overall societal disruption of make the financial services sector a prime target for cyber criminals using the latest techniques which are often undetectable with current solutions. A recent report by GreAT found 140 enterprises, including banks, affected by “file-less attacks” which use the system’s RAM to execute malicious code and are currently undetectable through conventional means. This is only one example of the numerous ways in which cyber criminals are innovating and developing new means of bypassing cybersecurity measures. REDSENTRY will provide a real-time networking monitoring platform to provide the ability to detect and manage any type of threat. By focusing on network monitoring REDSENTRY will provide enable financial sector institutions to manage their infrastructure in real time, proactively and with automatic security response protocols.

Keywords: real time network monitoring,cybersecurity,proactive operational intelligence,financial services,critical infrastructure
Bioengineered hippocampal organoids for epilepsy treatment (NEUROTILES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Epilepsy is a life-threatening progressive disorder causing uncontrolled activity of the brain (seizure); it carries among the highest burden of disease and significant social stigma. Temporal lobe epilepsy (TLE) is the most frequent syndrome, the least responsive to medications and the most linked to severe psychiatric and cognitive co-morbidities. When drug resistance ensues, neurosurgery and deep-brain stimulation are invasive options to carefully consider. Thus, TLE treatment demands urgent innovative interventions. Is it possible to generate ‘replacement parts’ to heal the diseased brain? The idea of repairing the brain using engineered transplants is nowadays more appealing than ever thanks to the ground-breaking advent of ‘mini-brains in a dish’ (brain organoids). Remarkably, brain organoids can be derived from human stem cells, thus carrying unique potential for targeted studies. However, their application in regenerative medicine has yet to thrive. Therefore, the interaction of brain organoids with mammalian brain tissue remains unexplored. In this project, I engage in the challenge of generating surrogate brain areas as transplants for epilepsy treatment. Specifically, I will focus on the hippocampus, a central structure in learning and memory which is crucially involved in TLE. I will push an unprecedented biohybrid design based on the synergetic exploitation of organoid technology and innovative neural engineering tools to pursue, for the first time ever, the establishment of a dialogue between engineered and mammalian brain tissue. The foundation of NEUROTILES stems in the emerging concept that brain repair strategies from regenerative medicine and neural engineering are distinct yet complementary. In the era of artificial intelligence and nanotechnology, NEUROTILES will promote a revolutionary framework for brain repair strategies and ultimately ignite the establishment of the novel field of ‘enhanced’ regenerative medicine.

Keywords: epilepsy,brain organoid,hippocampus,functional brain repair,biohybrid system,closed loop control,electrophysiology,brain slice
Pressurised Rotational Oil Transfer – Experimental Unit & System (PROTEUSS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: United Kingdom
Call: Oil Transfer Bearing for Advanced Pitch Change Mechanism (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-06-01
End date: 2023-07-31
Duration (months): 50.0
Total project cost (EUR): 2271333.75
EU funding (EUR): 2271333.75
Participants: 1
Project status: SIGNED

With the drive for engine cores to become smaller in size whilst operating at ever greater speeds and loads, the demands placed on the transmission systems are becoming ever greater. Correspondingly, effective lubrication, liquid cooling and hydraulic actuation are increasingly essential to the performance and life span of engine transmission systems. The above general trends, coupled with a recent resurgence of interest in open rotor engines, propel a need for new Oil Transfer Bearings (OTBs) to be developed. OTBs are required for two main reasons: (a) to provide both lubrication to bearings of planetary gears when the carrier of an epicyclic gearbox rotates and (b) to actuate movable objects on the rotating frame such as a blade pitch mechanism. The proposed experimental rig and supporting computational model will investigate both of these conditions simultaneously. UNOTT is well placed to carry out this work due to its experience in delivering high quality research relevant to bearings, seals, shafts and other parts of the gas turbine transmissions system that have become a feature in all recent engine development programmes at Rolls-Royce. This is an area of focus for the Gas Turbines and Transmissions Research Centre, which included a significant investment in research facilities that would allow research in this area of long-term strength at UNOTT to deliver benefits to the wider engines community and contribute to the global challenges we face to reduce noise and emissions.

Keywords: oil bearing,seals,gearbox,aero engine transmission system
The structures of the Early Modern Mediterranean shipbuilding (ModernShip Project)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-16
End date: 2021-05-15
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

The knowledge of modern naval architecture reached an important stage in the late 80’s with the first characterization of 16th century Ibero-Atlantic shipbuilding drafted by Thomas Oertling. Together with the contribution made by this work to the definition of an architectural model for the ‘Atlantic’ nautical space, it has paved the way for a better understanding of the spatial organization of shipbuilding, where two quite distinct technical cultures coexist, the first called "Atlantic" and the second called "Mediterranean". Over the last 30 years, however, little progress has been made in describing these models, particularly the Mediterranean one, due to a lack of wrecks. The discoveries of the wrecks of Mortella (1527,France) and Santiago de Galicia (1597, Spain), both of Mediterranean shipbuilding tradition, together with the discovery of the probable Mediterranean constructive origin of other wreck dated from the 16th c. (Yarmouth Road, UK) change this situation. The prospect of the analysis of this archaeological data in conjunction with that of the two already documented wrecks of Mediterranean origin (Lomellina and Calvi I, 16th c.) opens the way, for the first time, to the draft of a Mediterranean technical model. By comparing it to the Atlantic model, it also enable a first approach to the technical organization of European shipbuilding as a whole. Therefore, the essential objective of my research project is to contribute to the knowledge of these nautical spaces conceived as "technical spaces" by prioritizing the study of Mediterranean technical culture, still largely unknown, and to characterize it in relation to its Atlantic counterpart. It eventually aims to understand and highlight a shipbuilding system in which these two nautical spaces have been in continuous interaction since the Middle Ages, and to try to comprehend them in all the complexity of their exchanges and technological transfers.

Keywords: shipbuilding,naval architecture,early modern era,renaissance,mediterranean
Trans-generational immune priming: molecular basis and fitness consequences (TGIP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Understanding parasite and pathogen resistance is crucial for human and wild-life health. Even though recent genomic advances have refined our knowledge of parasite resistance, the role that trans-generational effects and epigenetics play remains poorly understood. To fill this knowledge gap, this project is designed around four different objectives: 1) Perform laboratory controlled experiment to disentangle the genetics and epigenetics of resistance; 2) Identify those epigenetic marks on the genome that are inherited and associated to increased parasite resistance; 3) Test for the maternal or paternal origin of those marks; 4) Test for the specificity of non-genetic response to parasite resistance when facing multiple diseases. For all those research objectives, we will use the three-spined stickleback (Gasterosteus aculeatus) as well-established model organism for host-parasite studies. Sticklebacks are virtually present in all water bodies of the Northern hemisphere, they have small and well described genomes and are easy to maintain under laboratory conditions. The combination of the unique study system (G. aculeatus), the quantitative breeding design, the molecular (bisulphite and next generation sequencing; NGS) and immunological techniques as well as the state-of-the-art statistical approach, makes the research outlined in the proposal highly original and competitive. This work will contribute to European excellence through further advancement of European science within the field of host-parasite interactions and pathogen resistance. Upon a successful completion of the project, results will have major implications for diverse research areas, e.g. immunology, speciation, genomics and medicine, but also it could revolutionize management of human and wildlife diseases and improve supportive breeding programs of endangered species.

Keywords: trans generational immune priming,specificity,three spined sticklebacks,epigenetics,host parasite interactions
International Conference on Research Infrastructures (ICRI 2016) (ICRI 2016)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Resilient Infrastructure
Action type: Coordination and support actions
Countries involved: South Africa
Call: INFRA (H2020-Adhoc-2014-20, 2015)
Start date: 2015-10-01
End date: 2016-12-31
Duration (months): 15.0
Total project cost (EUR): 623202.5
EU funding (EUR): 300000.0
Participants: 2
Project status: CLOSED

The next International Conference on Research Infrastructures, (ICRI), will be hosted in South Africa in October 2016. The Department of Science and Technology (DST) will be co-hosting ICRI 2016 with the European Commission (EC). In the recent few years, ICRI has become the platform for stakeholders to engage and interact on many of the critical research infrastructure (RI) related questions. ICRI 2016 will be an international event bringing together experts from across the globe and also seeking to make recommendations going forward for the RI community. It will bring together a set of speakers that are representative of the global debate on RI as well as target participation from across the world. The Conference will target multiple stakeholders including scientists, RI managers, multilateral institutions, policy makers, politicians, foundations as well as the private sector. The conference aims to attract 600-700 participants from across the globe. ICRI 2016 contributes to the general objectives stipulated in the European Commission’s work programme “European research infrastructures (including e-Infrastructures). The work programme highlights the role of RI within the context of the challenges that are faced globally. The themes of ICRI will be developed in a manner that also stimulates dialogue on the critical role that RI plays in addressing socio-economic challenges. The objectives will be to host a successful International Conference on Research Infrastructures (ICRI). The project will enable the successful organisation and implementation of the Conference, through key focus on project management; communication and branding; and logistics and organization. The Conference program will consist of a high level plenary, thematic discussions and exhibitions. The project will interface closely with the management structures, including the steering committee as well as the organising committee to deliver a successful event.

Keywords: international conference on research infrastructure,research infrastructure
Support Ecosystems for Digital Startups (DIGISTART)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Coordination and support actions
Countries involved: Sweden,Portugal,United Kingdom,Portugal
Call: Web Entrepreneurship (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2017-06-30
Duration (months): 30.0
Total project cost (EUR): 584375.0
EU funding (EUR): 584375.0
Participants: 5
Project status: CLOSED

Online Businesses are significantly different from traditional businesses due to a variety of factors such as relatively low entry costs, high word of mouth, low incremental costs, high efficiency of viral marketing strategies amongst others. Quick deployment, rapid prototyping, low cost of market tests and introduction along with the right business model and pricing strategy are some of the vital elements that can ensure success or failure. These challenges are quite daunting to cope even for seasoned entrepreneurs but much more challenging for younger entrepreneurs. While several startup initiatives, business accelerators and localised business support ecosystems have come up to provide these specialised skills and support services, the main barriers to a large scale web entrepreneurship ecosystem in Europe are: i) A significant gap between University Students who form the largest pool of potential young entrepreneurs and the business accelerators providing support to such initiatives. ii) Lack of internetworking between the various business accelerators, investors, mentors to coordinate their activities to reach a much wider audience across the widely dispersed European communities. iii) Lack of Business Analytical Tools that can help digital startups optimise their business models and pricing decisions. There is a strong need to develop an ecosystem of web entrepreneurship, where budding entrepreneurs can find the right support to let their ideas blossom into viable business models, with access to the necessary inputs such as funding, mentoring, and access to the necessary technical resources and IT skills. That is why 2 business accelerators from 2 different European regions: Portugal and Scandinavia came together to develop a coordinated set of support actions with the coordination of an academic partner (UNIDEMI) to leverage the use of the largest European Startup Web- Platform F6S for a range of activities that support web-startups.

Keywords: startup,online platform