Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Overcoming Barriers and Efficiency Limitations in Secure Computation (OBELiSC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Over the past few decades, our use of networks such as the Internet underwent a complete transformation: the data that we send over the network is now routinely used in computations by third parties. This creates a considerable threat to our privacy, as we witness countless data breaches and companies selling our private data. The aim of secure computation is to solve this problem. It studies the design of methods for computing on sensitive data without compromising confidentiality. Secure computation has been firmly established as one of the most promising approaches to reconcile the use of data-driven algorithms with the necessity of protecting our privacy. It has spurred a considerable research effort in the past decade, which has witnessed the emergence of new models, such as the models of secure computation with silent preprocessing (introduced by the PI), and of non-interactive secure computation. While these silent and non-interactive features are fundamental for the deployment of secure computation over large networks, current protocols suffer from important downsides which make them entirely impractical in real-world scenarios: - They scale poorly with the number of participants and cannot be used over mid- to large-size networks. - They either require many rounds of interaction (hence are impractical over high-latency networks) or trade non-interactivity for huge computational costs. - They induce a large communication overhead compared to executing the computation on the clear data. - They are often based on exotic cryptographic assumptions, whose security is not yet well-understood. The aim of the project OBELiSC is to explore the current limits of silent and non-interactive protocols, and to introduce new methods for overcoming the remaining barriers. The long-term vision of the project is to enable the deployment of a large-scale network that further protects our sensitive data whenever it is used in distributed computation.

Keywords: secure computation,multiparty computation
GRAVITational StoragE, Quantum computing, and AI for enhanced Circularity and Reliability in Clean transition-affected sector-coupled electricity grids (GRAVITEQA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Countries involved: Greece,Bulgaria,Spain
Call: Emerging energy technologies for a climate neutral Europe (HORIZON-CL5-2024-D2-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 2499990.0
EU funding (EUR): 2499990.0
Participants: 10
Project status: SIGNED

The clean energy transition requires at least a 55% reduction in GHG emissions (from 1990 levels) by 2030, according to the ‘Fit for 55’ package. Thus, electricity grids will be called upon to operate in an overall context of 50% electricity production from RES of any scale by 2030. Thus, several challenges will become even more apparent in the following years: (i) reliability issues in electricity grids due to rapid decarbonization, (ii) lack of circularity in conventional power plant’s decommissioning process, (iii) operational issues in sector-coupled systems under mass electrification scenarios, (iv) significant computation and data processing efforts are required to manage the future grid. GRAVITEQA highlights the synergetic benefits of gravitational storage, Quantum Computing (QC) and Quantum Inspired Computing (QIC), and data-driven, trustworthy AI-based analytics services. GRAVITEQA develops and validates 9 components/methodologies up to a TRL 4: (i) QC and QIC for the Facility Location Allocation and Load-side assets management problems, (ii) a generic and holistic methodology to find the optimal energy storage technology or mix of them, to transform a coal power plant and mine into a long duration energy storage plant, (iii) repurposing of available assets case study capable of providing long-term storage and enhancing recyclability of a under-decommissioning thermal power plant and an abandoned coal plant, (iv) conformal prediction for robust energy demand of cold ironing, (v) optimal charging of cold ironing and EVs respecting grid constraints for reliable green port operation, (vi) seaport electrification strategy for seaports: analysis and scenarios planning, (vii) fast nodal flexibility region estimation algorithm for 3-phase grids unlocking the flexibility services procurement from distributed RES, (viii) end-to-end trustworthy learning for non-convex optimization problems, and (ix) a reference design for edge inference in smart grid applications.

Keywords: quantum computing,long term energy storage,transmission and distribution grids,energy conversion,trustworthy ai learning,recyclability,explainable ai,non convex optimization
Confidently Changing Colonial Heritage (CONCILIARE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Portugal,Belgium,Netherlands,Italy,Finland,Croatia
Call: Cultural heritage in transformation – facing change with confidence (HORIZON-CL2-2023-HERITAGE-01, 2023)
Start date: 2024-03-01
End date: 2027-02-28
Duration (months): 36.0
Total project cost (EUR): 2741606.25
EU funding (EUR): 2741606.25
Participants: 13
Project status: SIGNED

OBJECTIVES: CONCILIARE centers on the ongoing changes in Colonial Cultural Heritage (CCH) with a threefold aim: 1) identifying and analyzing changes in CCH across four pivotal domains: textbooks, public spaces, museums and cultural consumption of products and traditions; 2) advancing knowledge on reactions to and representations of changes in CCH in the four domains held by diverse sociodemographics groups (ethnic, gender, generation, and cultural contexts); 3) propose four different methods – one per domain – to promote confidence in changes in CCH. HOW THEY WILL BE ACHIEVED: To accomplish these objectives, CONCILIARE proposes an interdisciplinary (social sciences and humanities studies) and multi-methodological (small scale applied qualitative and quantitative) approach. Each domain will be covered by a specific work package (WP1-4) with methodologies linked to two axes: Axis 1 respecting to CCH: changes, reactions and representations and Axis 2 to promoting confidence in changes in CCH. Four small scale pilot trials will be carried out – one per domain – in different European countries to test the effectiveness (assumptions and applications) of the four proposed methods in fostering confidence in CCH changes across the diversity of Europe. THEIR RELEVANCE TO THE WORK PROGRAMME: The accomplishment of these objectives will allow CONCILIARE to meet the two envisaged expected outcomes of contributing to a “deeper and broader understanding of the constantly changing nature of cultural heritage and of how this understanding can be effectively shared by citizens” and to the “the development of evidence-based methods, tested in small scale, to help citizens face current and future societal transformations with greater confidence”.

Keywords: colonial cultural heritage representations collective memories confidence in change intergroup relations european identity values emotions textbooks public spaces museums cultural consumption
Designing Efficient Water-Based Nanopesticides for Sustainable Agriculture (ENASA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom,Cyprus
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-01
End date: 2028-02-29
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 3
Project status: SIGNED

Pesticides are vital for global food productivity. Traditional formulations pose environmental risks due to their heavy reliance on organic solvents and surfactants. Nanopesticide formulations (NPF) offer safer, eco-friendly alternatives but are often costly and complex. The ENASA project aims to simplify this by developing pure water-based nanopesticide formulations (PW-NPF) that are free of organic solvents and use minimal surfactants for plant production. To achieve this goal, researchers will undergo secondment at Queen Mary University of London (QMUL) for training in molecular dynamics simulation to aid in designing amphiphilic water-soluble surfactants for constructing PW-NPT. Subsequently, a secondment at NovaMechanics Ltd (NovaM) will use computational modeling to establish relationships between surfactant configurations and pesticide structures, enabling the prediction of structure-activity relationships and broader applications. This project has the potential to unlock the application of many pesticide varieties through formulation innovation, especially considering the high costs of developing new pesticides today. Additionally, it represents a crucial step for the fellow, who is in the early stages of his career, on his path to becoming an excellent researcher in the field of nano-agrochemicals.

Keywords: plant protection,pesticide formulation,nanopesticides,water based nanodelivery,sustainable agriculture
The ethics of early risk and cancer detection: a Study on Experiences of Active Surveillance in Oncology (SEASOn)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,Switzerland,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-09-30
Duration (months): 25.0
Total project cost (EUR): 271441.34
EU funding (EUR): 271441.34
Participants: 3
Project status: SIGNED

Early risk and cancer detection are at the heart of Europe's strategy in the fight against cancer. The belief underlying these efforts is that if we can detect and treat cancer as early as possible, then we can prevent its progression towards metastasic of fatal disease. However, many types of cancer follow profoundly heterogeneous trajectories: some may indeed become very severe if not treated, while others may remain stable or regress on their own. In order to circumvent ethical issues related to overdiagnosis and overtreatment, active surveillance is often selected in order to assess through time the potential evolution of the disease towards more severe stages. The population of persons who are placed under active surveillance is thus rapidly growing through the current push for early risk and cancer detection and the accessibility of new diagnostic technologies. These “patients-in-waiting" live with great uncertainty, not knowing if and when they will ever need to be treated for cancer. The "invisibility" of this population withrepresents a significant public health challenge, as concerned patients' needs and distress may remain unseen, disregarded or dismissed. SEASOn’s main goal is to co-construct an ethical framework to address issues raised by the development of early risk and cancer detection as well as the needs and vulnerability of patients-in-waiting under active surveillance in oncology. Based on field work to gather qualitative data (semi-structured interviews and ethnographic observations) and on participatory methodologies (public and patient involvement, structured dialogues), SEASOn will (1) evaluate how oncologists introduce and explain the need for active surveillance to concerned patients; (2) analyse concerned patients’ experiences, expectations and needs surrounding active surveillance; and (3) co-construct an ethical framework with concerned stakeholders and highlight priorities for the improvement of surveillance pathways.

Keywords: empirical bioethics,active surveillance,oncology,early detection,risk,vulnerability,uncertainty
Stabilization of Protein Protein Interactions; transforming molecular glue discovery from art into science (PPI-Glue)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2496596.0
EU funding (EUR): 2496596.0
Participants: 1
Project status: SIGNED

Intrinsically Disordered Proteins (IDPs) represent one of drug discovery’s major challenges. Due to their high degree of conformational freedom, IDPs have no defined pockets for binding small molecules. Molecular glues that can strengthen protein-protein interactions (PPIs) are a revolutionary technology for drug discovery. The hub protein 14-3-3 regulates many IDPs via phosphorylation-dependent PPIs. Stabilization of 14-3-3 PPIs with small molecular glues provides a unique entry point to render IDPs druggable and mitigate the aberrant behaviour of malfunctioning IDPs, for example in neurodegenerative diseases. While inhibition of PPIs by small molecules has expanded the proteome suitable for therapeutic intervention, the opposite chemical-biology strategy of PPI stabilization by small molecular glues is, despite a recent surge of interest, remarkably underexplored. The lack of mechanistically understanding PPI stabilization impedes systematically identifying molecular glues and limits progress to drug IDPs. Based on compelling preliminary data, I propose here that mechanistic understanding of 14-3-3 PPI stabilization will play a crucial role in the discovery of molecular glues for IDPs and transform molecular glue drug discovery from art into science. We will tackle this central question by pursuing two key objectives: Objective 1 – Mechanistically understand PPI stabilization between the 14-3-3 scaffold protein and IDPs. This will address the underlying thermodynamic and kinetic processes, conformational selection, multivalency, cooperativity and selectivity; Objective 2 –Drugging the undruggable -biomolecular condensates and IDPs- via PPI stabilization approaches. The potential for PPI stabilization in the dense environments of biomolecular condensates will be uncovered and a mechanism-driven campaign to identify molecular glues for the 14-3-3/Tau PPI will lead the way to novel drug discovery for neurodegenerative diseases.

Keywords: protein protein interactions 14 3 3 molecular glues cooperativity selectivity
Charting the evolution of protein-protein interaction networks shaping plant metabolic adaptation to land (EPPIMAL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-01
End date: 2025-01-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: CLOSED

Plant colonization of land was a critical evolutionary step for terraformation and the emergence of rich terrestrial ecosystems. Land plant ancestors emerged from freshwater algae and subsequently radiated to yield the astonishing diversity observed nowadays. Extant land plants comprise two major groups, tracheophytes and bryophytes, which represent the vascular and non-vascular stage of their evolution. Recent advances in phylogenomics indicate that the water-to-land transition was accompanied by the emergence and/or expansion of protein families that founded novel plant metabolic pathways. This has been for instance the case for the pathways generating phenylpropanoids, specialized molecules serving as anti-UV and precursors to structural polymers, and the hormones abscisic acid (ABA) and strigolactones (SL) that help plant coordinate stress responses and interaction with microorganisms. While these three plant metabolic pathways are almost fully elucidated, little is known about (i) the organization of involved proteins in interacting networks and (ii) the evolutionary relevance of protein-protein interaction (PPI) networks for the emergence and function of metabolic pathways. EPPIMAL project proposes to answer these questions by exploring the evolution of PPI networks associated with the phenylpropanoid, ABA and SL metabolisms. The project will implement a cutting-edge proximity-dependent labeling (PDL) approach centered on key enzymes to characterize PPI networks in bryophyte and tracheophyte species. The project shall disclose the conservation or expansion of PPI networks in the course of land plant evolution and potentially identify overlooked protein involved in investigated metabolic pathways. PPI data will be complemented with molecular genetics and metabolomics investigations. Altogether, EPPIMAL will bring original information on the evolution of protein networks shaping three iconic land plant metabolic pathways that supported plant adaptation to land.

Keywords: protein protein interaction,plant evolution,bryophytes,plant metabolism,plant hormones
Melting and dissolution across scales in multicomponent systems (MultiMelt)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Melting and dissolution induce temperature and concentration gradients in liquid systems. These gradients induce flows, namely buoyancy driven flows on large scales and phoretic flows on small scales. Such flows locally enhance or delay the melting or dissolution process and thus determine the objects’ shape. On large scales, a relevant example for the climate are glaciers and icebergs melting into the ocean, where cold and fresh meltwater experiences buoyant forces against the surrounding ocean water, leading to flow instabilities, thus shaping the ice and determining its melting rate. Another example is the dissolution of liquid CO2 in brine for CO2 sequestration. Next to buoyant forces also phoretic forces along the interfaces come into play. For dissolving drops at the microscale the phoretic forces become dominant. The resulting Marangoni flow not only affects their dissolution rate, but can also lead to their autochemotactic motion, deformation, or even splitting. In spite of the relevance for these and many other applications, such multicomponent, multiphase systems with melting or dissolution phase transitions are poorly understood, due to their complexity, multiway coupling, feedback mechanisms, memory effects & collective phenomena. The objective of this project is a true scientific breakthrough: We want to come to a quantitative understanding of melting & dissolution processes in multicomponent, multiphase systems, across all scales and on a fundamental level. To achieve this, we perform a number of key controlled experiments & numerical simulations for idealized setups on various length scales, inspired by above sketched problems, but allowing for a one-to-one comparison between experiments and numerics/theory. For the first time, we will perform local measurements of velocity, salt concentration, and temperature and connect them to global transport processes, to arrive at a fundamental understanding of such Stefan problems in multicomponent systems.

Keywords: turbulent thermal convection,double diffusive convection,taylor couette turbulence,melting,dissolution,marangoni force
Properties of quantum gravity from effective field theories (PROFIT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 292118.88
EU funding (EUR): 292118.88
Participants: 1
Project status: SIGNED

General relativity (GR) has led to remarkable scientific progress, most notably with the recent detection of gravitational waves (GW). This success has prompted efforts to build new GW experiments (e.g. Einstein Telescope, Laser Interferometer Space Antenna) and as a result, it is now time to refine theoretical models and implement precision tests of gravity. However, despite these advances, GR falls short as it fails to provide a complete description of a quantum theory of gravity. To probe new physics, at higher energy scales as quantum gravity dictates, it is essential to work beyond GR. This is achieved by introducing certain types of modifications, in the formalism of effective field theories (EFT). A complete scheme to constrain the EFT is not known and in turn, the physical consequences of a given EFT is limited. Moreover, modified theories of gravity become increasingly challenging to study from a computational perspective. As a result, there is limited access of solutions in EFT extensions of gravity, highlighting the need to develop new technical and mathematical methods to learn about these theories and their solutions. Therefore, the objective of this action is twofold. First, I will investigate modified theories of gravity, implementing a unique physical constraint, understanding how this constraint dictates a unique form of the EFT and as a result, compute the observations consequences, relevant to GW. Second, having comprehensively studied such EFTs and identified their key features, I intend to search for novel solutions of these theories. I will compute the quantum signatures of these solutions, connecting them to quantum gravity. As a fellow, this action allows me to conduct research on current challenges at the forefront of theoretical physics, enhancing my scientific expertise. As a result, I will increase my visibility in the field, fostering my independence and setting the stage to lead my own research team.

Keywords: gravity,modified theories of gravity,black holes,holography,effective field theories,quantum corrections,quasinormal modes,string theory,higher derivatives,dualities,general relativity