Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Commercialization of simulator for interventional echocardiography, specializing in the field of minimally invasive medical therapies. (TEEMothyTS Simulator)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Poland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2020-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cardiovascular diseases are the main cause of death - only in Europe they account for over 35% of all deaths. Minimal invasive surgery is the most important available treatment technique because it limits interference in the patient's body and significantly shortens recovery time compared to standard invasive procedures. Although professionals are trained in this technique, learning to operate the probe is very difficult and troublesome for both the doctor and patient. In response to the market demand, MST has developed a device, simulator for interventional echocardiography, specializing in the field of minimally invasive medical therapies. The solution is a comprehensive simulation system consisting of software and hardware. The simulation platform based on a heart model from CT scans of real patients. This allows the user to practice on the most realistic heart models with numerous individual anatomies and pathologies and have the feeling of real examination or interventional TEE-guided procedure. The new device will be easy to use, and portable enough to compete with by its mobility. Lower costs of manufacturing and exploitation provides an opportunity to supply market demand to a greater extent than competition currently does. Professional unique solution based on real patient’s heart models with 3D visualization provides higher quality than any device currently available. Incorporated fluoro- and TEE guided puncture simulators build usability. The initial target market concentrate around the USA and Europe – Germany, France, Austria, Italy and Poland. The company is already present in these markets, therefore they are accessible to the new product. MST has developed partnerships with disturbing companies for global presence. ProfiMedical (www.profimedical.pl) is a distributing partner of MST. It specializes in medical equipment sales in Central and Eastern Europe.

Keywords: cardiovascular simulator,minimal invasive surgery,wellbeing
Global Impact Assessment of Regulations and Policies for Sustainable Aviation by 2050 (GLIMPSE2050)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Coordination and support actions
Partnership: CS2 (Art-187)
Countries involved: Netherlands
Call: Environmental regulations and policies (H2020-CS2-CFP09-2018-02, 2018)
Start date: 2019-10-01
End date: 2021-03-31
Duration (months): 18.0
Total project cost (EUR): 193670.0
EU funding (EUR): 193670.0
Participants: 1
Project status: CLOSED

Cross-positioned in Clean Sky 2 and part of Clean Sky 2 TE, GLIMPSE2050 quantifies the environmental impact at air transport system level up to 2050 of regulations and policies that are currently discussed and potentially introduced until 2040. This impact includes noise and emissions. From this quantification, GLIMPSE2050 provides recommendations to target stakeholders. Through its quantification, GLIMPSE2050 helps to understand which environmental benefits can be achieved in addition to those brought by Clean Sky 2 technologies. This understanding subsequently helps to evaluate to which extent technology diffusion in aviation can reach the ACARE Flightpath 2050 environmental goals. GLIMPSE2050’s concept is twofold: first it sets the assessment scope by a systematic selection of regulations and policies and of target stakeholders; then it sets the quantification process, building on proven and successfully applied approaches. For every year 2020/2025/2030/2035/2040/2045/2050, this process compares the environmental performance of two scenarios: one is a projection of the air transport system in that year based on autonomous economic, demographical and technological developments but without the regulations and policies; the other is a projection of the air transport system in the same year, but with the regulations and policies introduced. In these scenarios, Clean Sky 2 technologies are considered an autonomous technological development. GLIMPSE2050 expects to impact Clean Sky 2 TE (by complementing the other assessments), Clean Sky 2 JU and Clean Sky 2 Members (by monitoring Clean Sky 2 achievements in a broader perspective), EC and EU Member States (by assessing the level of success towards the ACARE Flightpath 2050 goals), aviation sector (by providing capabilities to assess effects on business development), research community (by indicating opportunities for further research), and society (by displaying effort and progress in sustainable aviation).

Keywords: clean sky 2,environmental impact,noise,emissions,aviation regulations and policies,air transport system
Device for improving the value of the Classic/Mechanic stethoscope – An innovative device for improvement, digitization and recording of the sound. (STETHOTELEPHONE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-10-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

STETHOtelePHONE is an add-on device able to digitize the sounds detected by any classic stethoscopes with the aim to improve it (by amplifying and filtering), and finally send it to ICT devices. Through a SW application, it allows to record and share auscultation among specialists, with the aim to improve diagnosis and monitoring of pathologies and perform Remote Patient Monitoring (RPM) services. Being posed instead of the ears of the “examiner”, STETHOtelePHONE is the unique device, protected by a PCT patent, able to digitize the natural sound exactly as it is heard by the examiner. All the Electronic stethoscope on the market, depends critically on the electro-acoustic properties of the sensors, used to acquire the signals of interest, and this is reflected in no existing acoustical standards for characterizing electronic stethoscopes; This lack, reduce the trust of physicians in an electronic based auscultation; they need to be trained for the sound electronically transduced. This project has the ambition to allow a better diagnosis of COPD and valvulopathies. Furthermore, STETHOtelePHONE will strengthen RPM services. European data show the business opportunity: at least 1 out of 5 people suffers from chronic diseases suitable for homecare and 4 out of 5 citizens classify medical errors as an important issue. Patient anxiety, due to uncertain diagnosis, is reflected in expensive additional testing: the average price for an echocardiogram range from $1,000 to $3,000. The Global market demand of digital stethoscope from 2018 until 2022 is of 8 Million units. The users are hospital and clinics; cardiologists, general practitioners, and students; and company providing RPM services. The feasibility study planned for phase 1, will contribute to define the product engineering and production roadmap and assess the commercialization strategies enhancing the quality of the company´s BP and contributing to the market replication success.

Keywords: diagnosis,education and training,stethoscope
How complement molecules kill bacteria (ComBact)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-03-01
End date: 2020-02-29
Duration (months): 60.0
Total project cost (EUR): 1497290.0
EU funding (EUR): 1497290.0
Participants: 1
Project status: CLOSED

This proposal aims to provide insight into how bacteria are killed by the complement system, an important part of the host immune response against bacterial infections. Complement is a large protein network in plasma that labels bacteria for phagocytosis and directly kills them via the formation of a pore-forming complex (Membrane Attack Complex (MAC)). Currently we do not understand how complement activation results in bacterial killing. This knowledge gap is mainly caused by the lack of tools to study the enzymes that trigger MAC formation: the C5 convertases. In my lab, we recently established a novel assay system for C5 convertases that allows us for the first time to study these enzymes under purified conditions. This model, combined with my expertise in microbiology, places my lab in a unique position to understand C5 convertase biology (Aim 1), determine the enzyme's role in MAC functioning (Aim 2) and elucidate how the MAC kills bacteria (Aim 3). Thus, I aim to provide insight into the molecular events necessary for bacterial killing by the complement system. I will use biochemical, structural and microbiological approaches to elucidate the precise molecular arrangement of C5 convertases in vitro and on bacterial cells. I will generate unique tools to study how C5 convertases regulate MAC insertion into bacterial membranes. Finally, I will engineer fluorescent bacteria and labeled complement proteins to perform advanced microscopy analyses of how MAC kills bacteria. These insights will lead to fundamental knowledge about the functioning of complement and will create new avenues for blocking the undesired complement activation during systemic infections and acute inflammatory processes. Furthermore this knowledge will improve desired complement activation by therapeutic antibodies and vaccination strategies in infectious diseases. Finally, this work opens up new possibilities to understand how both humans and bacteria regulate complement.

Keywords: complement,bacteria,convertases,membrane attack complex
The ultimate Time scale in Organic Molecular opto-electronics, the ATTOsecond (TOMATTO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Spain,Italy
Call: ERC Synergy Grant (ERC-2020-SyG, 2020)
Start date: 2021-04-01
End date: 2027-03-31
Duration (months): 72.0
Total project cost (EUR): 11726141.25
EU funding (EUR): 11726141.0
Participants: 4
Project status: SIGNED

Photoinduced electron transfer (ET) and charge transfer (CT) processes occurring in organic materials are the cornerstone of technologies aiming at the conversion of solar energy into electrical energy and at its efficient transport. Thus, investigations of ET/CT induced by visible (VIS) and ultraviolet (UV) light are fundamental for the development of more efficient organic opto-electronic materials. The usual strategy to improve efficiency is chemical modification, which is based on chemical intuition and try-and-error approaches, with no control on the ultrafast electron dynamics induced by light. Achieving the latter is not easy, as the natural time scale for electronic motion is the attosecond (10-18 seconds), which is much shorter than the duration of laser pulses produced in femtochemistry laboratories. With femtosecond pulses, one can image and control “slower” processes, such as isomerization, nuclear vibrations, hydrogen migration, etc., which certainly affect ET and CT at “longer” time scales. However, real-time imaging of electronic motion is possibly the only way to fully understand and control the early stages of ET and CT, and by extension the coupled electron-nuclear dynamics that come later and lead (or not) to an efficient electric current. In this project we propose to overcome the fs time-scale bottleneck and get direct information on the early stages of ET/CT generated by VIS and UV light absorption on organic opto-electronic systems by extending the tools of attosecond science beyond the state of the art and combining them with the most advanced methods of organic synthesis and computational modelling. The objective is to provide clear-cut movies of ET/CT with unprecedented time resolution and with the ultimate goal of engineering the molecular response to optimize the light driven processes leading to the desired opto-electronic behavior. To this end, synergic efforts between laser physicists, organic chemists and theoreticians is compulsory.

Keywords: attosecond chemistry,electron and charge transfer,organic optoelectronics,molecular wires,attosecond pump probe,quantum chemistry of attosecond molecular science,organic synthesis,carbon nanostructures
Feasibility study for water leakage detector CiWater (CiWater)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Sweden
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

A water distribution network is an important part of the infrastructure. In every water pipe system around the world more than 20% of the produced water is lost before it reaches the consumer, corresponding to a production cost of more than 20 M€ every day. It is a challenge to find small leakages before they became major and causing an emergency. Cinside has the ambition to grow and internationalise. With this project we will get a new innovative and unique product that strengthens the company's competitiveness in the environmental area and increasing the future revenue opportunities. The main selling points are to save money, energy and valuable nature resources. The system has a worldwide market with the potential of 100000's of users. The aim is to develop a handheld radar based system to pinpoint the leakages in a more accurate and effective way than available methods like correlator and electro-acoustic techniques. The idea is to use the Cinside proprietary hardware and Doppler signal processing previously developed to find humans behind walls and in rubble by detecting very small physical movements. In a previous project we have built a demonstrator showing that we can detect water leakages in certain environments. To get a fully working easy-to-use product we need to gain more experience from different leakage conditions. In phase 1 we will investigate the properties of different leakage conditions, and from that make a project plan for development in phase 2. We will also do a market survey to be able to setup a realistic business plan. We will search for certain experts and end-users around Europe, in addition to the end-user group already formed in Sweden, to find partners willing to participate in phase 2. In phase 2 we will develop the product from TRL6 to TRL9. The participating end-users will contribute with experience, trial areas, real leakages and verification. To complete this project we will need external financing.

Keywords: fresh water,leakage,distributing,radar,signal processing,portable,affordable,effective,pinpoint,cinside
Estimation of the term premium in Euro Area government bonds (EUTERPE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-05-01
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

The European monetary authorities, as well as most central banks, are currently pursuing the objective of reducing the Quantitative Easing and normalize interest rates. A clear understanding of the forces underlying the movements in interest rates has thus become a timely and very relevant issue. In particular, a challenging task for policymakers is the estimation in real time of the unobservable term premium, which provides a measure of the investors’ perceived risk of holding government bonds. The purpose of the EUTERPE (EUropean TERm Premium Estimation) project is to implement an innovative system producing timely and reliable estimates of the term premium and its components for government bonds of the Euro Area (EA). The project aims to fill an important gap in the existing literature by proposing an integrated procedure which relies on a novel multi-country term structure model with interrelation between yield curves, macro variables, volatility, and global factors. EUTERPE intends to equip the European policymakers with a new analytical tool for their monetary policy decisions and has potentially various applications in the financial industry, thereby representing a way to use knowledge in Europe effectively for business and policy purposes. The specific training activity in research and transferable skills, the outstanding profile of the Supervisor, the excellent research environment offered by the host institution, and the interaction with a first-class network of European policymakers and research institutions are all factors which will contribute to increase my professional maturity and will allow me to restart a career in research at an advanced level. In particular, the publication of the results in highly reputable scientific journals and the other dissemination activities will strengthen my profile both for European universities and for research departments of international financial institutions and will open up new interesting career opportunities.

Keywords: european government bonds,term premium,inflation risk premium,term structure and macroeconomy,time varying volatility,global factors,kalman filter,dynamic factor analysis,yield curve smoothing
Marine Stratocumulus Cloud Cover and Climate (MSCCC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Global climate change is forced by the balance of the warming due to anthropogenic greenhouse gases and the cooling due to anthropogenic aerosol pollution particles. Among these, the cloud-mediated aerosol radiative forcing is by far the main component of the uncertainty. Marine stratocumulus clouds in particular play a decisive role due to their very large net effect on the Earth's radiative energy budget. Stratocumulus clouds occur in the two main regimes of open and closed cells that differ significantly by their cloud cover, and thus by their radiative effect. The main hypothesis of this proposal is that anthropogenic aerosols exert a substantial radiative forcing via their potential to impede or delay the transition from closed to open cells marine stratocumulus, and that this presumably un-buffered effect is not accounted for in forcing estimates by current climate models. The Marine Stratocumulus Cloud Cover and Climate (MSCCC) project aims to improve the quantification, at a global, multi-year scale, of the radiative forcing on climate that anthropogenic aerosols exert by affecting stratocumulus cloud cover. To achieve this goal an inter-disciplinary approach that involves both observations and climate modelling is required. I will develop novel satellite observation methodologies in order to retrieve an in-depth understanding of the processes relevant for the transitions between closed and open stratocumulus regimes, and based on these I will evaluate and improve the relevant climate model parameterizations to realistically represent the forcing by aerosols due to stratocumulus transitions in climate models. This will allow to significantly reduce the uncertainty in simulated aerosol-cloud radiative forcing, and subsequently also in simulated climate sensitivity and projections of future climate change. Achieving these goals will be performed in synergy with my training to acquire complementary knowledge and skills in climate modelling.

Keywords: cloud radiative forcing,aerosol cloud interactions,marine stratocumulus clouds,anthropogenic aerosols effect on cloud cover,climate change,global climate modeling,satellite observations
multipurpose robotics for mAniPulation of defoRmable materIaLs in manufacturing processes (APRIL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Spain,Italy,Spain,Italy,Spain,Türkiye,Hungary,Poland,Portugal,United Kingdom
Call: Handling systems for flexible materials (RIA) (H2020-NMBP-FOF-2019, 2019)
Start date: 2020-04-01
End date: 2024-03-31
Duration (months): 48.0
Total project cost (EUR): 7926391.25
EU funding (EUR): 7926391.25
Participants: 15
Project status: SIGNED

APRIL project aims at implementing and deploying market oriented, low cost and multipurpose robots that supports semi-automatic tasks in manufacturing production lines that use flexible or deformable materials in industries of any size or domain. APRIL will use fine grasping, innovative computational vision technology, gathering of sensors’ information, as well the development of modular and different middleware layers and interfaces. APRIL will provide innovative sensoring and computational vision supporting detection of slips, estimate weight, dynamic center of mass, or regulating grasping forces while manipulating deformable objects of different types (e.g. paper, chicken breast, shoes’ insoles, viscoelastic textile materials, cables, etc.). A federated approach, wireless communication, usage of multipurpose hands and placement of various sensors, will connect all robots to a cloud based knowledge base that will contain the needed information to perform the different jobs. APRIL system will be deployed in six different demonstration use cases across Europe. Robots integrated in the manufacturing processes will operate on several critical steps that affect production, packing and quality assurance on the different manufacturers involved as pilot sites. On one hand, introduction of APRIL system will produce an expected increase on safety and related health conditions of working environments. On the other hand, APRIL will enable an increase on productivity and quality of the final products; thus leading to a greater competitiveness of European industry. The project will be implemented in 40 months by 15 partners from 8 European countries.

Keywords: automation,federated robots,flexible manufacturing,manipulation of flexible materials,robot hands