Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
UNIfied Cosmology Across Lensing Surveys (UNICALS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

According to the current consensus cosmological model, dark matter and dark energy make up most of the energy density of the universe. However, their physical nature is still unknown and understanding them presents a grand challenge. Moreover, there are unresolved tensions between observations from the late-time and the early-time universe. Intriguingly, all weak lensing analyses favour a smoother matter distribution than Planck's Cosmic Microwave Background observations. In order to assess if this discrepancy is due to unaccounted systematics or new physics, it is essential to analyse the existing weak lensing datasets with a unified pipeline. This effort is especially required as we approach the next generation of dark energy surveys —including ESA's Euclid mission, the Vera C. Rubin Observatory Legacy Survey of Space and Time, and the Nancy Grace Roman Space Telescope— since they will provide unprecedented high-quality data that will increase the statistical power by orders of magnitude. In this project, we will combine for the first time the final data sets from the current generation of dark energy surveys (DES, KiDS and HSC) to obtain competitive cosmological constraints from the joint analysis of galaxy clustering and weak lensing. For this purpose, we will develop a novel unified modelling and inference pipeline to fully exploit the statistical power of the different surveys in an optimal way. The methodology developed and employed in this project will be crucial to shed light on the existing tensions with Planck and the nature of dark energy with ESA's Euclid mission, the Rubin Observatory and the other upcoming dark energy surveys.

Keywords: cosmological parameters,galaxy clustering,weak gravitational lensing,sky surveys
Perovskite Ferroelectric Materials For Sustainable Energy Technologies (OFFSET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2027-04-30
Duration (months): 36.0
Total project cost (EUR): 261380.64
EU funding (EUR): 261380.64
Participants: 2
Project status: CLOSED

Many governments are working towards decarbonising their economies, with the EU having set net-zero targets to be reached by 2050. At the moment, however, still about 70% of all the world’s power comes from burning fossil fuels (i.e. coal, oil, gas). It is clear that in order for these goals to be feasible and economically viable, the way we generate and use energy needs to change drastically. One way of addressing this challenge is research into novel, more advanced classes of quantum materials where, broadly speaking, new structural and electronic properties can start to emerge. Here, ferroelectrics are a leading candidate for achieving high-performance energy technologies. OFFSET aims to explore the potential of ferroelectric materials for future energy applications by focusing on one specific material class, nitride perovskites. While the properties of many nitride perovskite candidates have already been studied computationally, experimental realisations have been lacking, hindering potential applications. In order to achieve these goals, OFFSET aims to synthesise a number of structures using molecular-beam epitaxy. This will be combined with advanced characterisation techniques, including cryogenic and structural measurements as well as piezoresponse atomic-force and transmission electron microscopy, in order to assess their quality and quantify the piezoelectric/ ferroelectric response. At a later stage, OFFSET also aims to explore potential technological applications including uses as memories, photovoltaics and/or thermoelectrics. This will be achieved via an advanced nanofabrication programme, making use of the cleanroom facilities available at both project partners. With these efforts, OFFSET expects to acquire fundamental knowledge on the viability and feasibility of nitride perovskites for use in future energy technologies.

Keywords: ferroelectrics nitride perovskites molecular beam epitaxy nanofabrication energy technologies
COMORBIDITY MECHANISMS UTILIZED IN HEALTHCARE (COMMUTE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Germany,Luxembourg,Denmark,Spain,United Kingdom,Hungary,Austria,France,Netherlands
Call: Relationship between infections and non-communicable diseases (HORIZON-HLTH-2023-DISEASE-03, 2023)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 7280986.25
EU funding (EUR): 7280986.25
Participants: 13
Project status: SIGNED

The COVID pandemic can be seen as an experiment done with the entirety of humankind (as almost everybody has been or will get infected with SARS-CoV-2). It will therefore have the best coverage over the widest variation possible and is therefore ideally suited to study the effects of infections with SARS-CoV-2 on large quantities of heterogeneous individuals. In our project, we will focus on neurodegenerative diseases (NDDs), namely Alzheimer and Parkinsonism, as the NCDs under investigation. COMMUTE is a project characterized by the intelligent combination of two fundamentally different approaches: a hypotheses-free, data-driven approach is building on available big data and the application of cutting edge AI/ML technologies to answer the question, whether infection by SARS-CoV-2 causes effects that result in a higher risk for the development of NDDs at population-level. Complementary to that, a hypothesis-driven, knowledge-based approach leverages the substantial knowledge in the scientific community working on NDDs on the putative comorbidity mechanisms linking COVID and neurodegeneration. Both approaches are informing and supporting each other through an intensive crosstalk between computational and experimental biology methods. Understanding comorbidity between COVID and NDDs at causal level is the first goal of the COMMUTE project. The second goal is the translation of the actionable insights into personalized health applications. On the AI/ML side, the targeted outcome for translation into practice is a set of qualified biomarkers and predictive features that will be used for an AI-powered, model-generated recommender system that will allow for individualized risk assessment and personalized recommendations. On the side of the biomedical assay systems, COMMUTE will use cell-based assays based on clear pathophysiology mechanism understanding for drug-repurposing screenings in collaboration with REMEDI4ALL, the largest of the EU drug repurposing platforms.

Keywords: comorbidity mechanisms,artificial intelligence,data driven,knowledge driven,covid,neurodegeneration,integrative approach,causal machine learning,real world data
the new generation of scalable urban HEat isLand mitigatIOn by means of adaptive photoluminescent radiative cooling Skins (HELIOS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-05-01
End date: 2027-04-30
Duration (months): 60.0
Total project cost (EUR): 1498125.0
EU funding (EUR): 1498125.0
Participants: 1
Project status: SIGNED

From their early origins urbanization has produced both benefits and penalties due to the generated anthropogenic stress. Documented overheating such as urban heat island (UHI) compromises human wellbeing in cities, where 60% of the world population lives and is exposed to the related health risks and vulnerability. An urgent solution is much needed here and now, since classic passive cooling techniques showed to slowly mitigate UHI. A disruptive improvement must be dedicated to eradicate the problem by conducting a ground-breaking multidimensional and multidisciplinary research. That is the key motivation of HELIOS, which aims at holistically developing the resilient urban skin of the future. This skin will take advantage of the combination of successful radiative cooling in the atmospheric window(8-13μm) and high solar reflectance integrated for the first time to photoluminescence in the short wave(0.25-2.8μm) thanks to the breakthrough lead-free halide perovskites. HELIOS will develop novel radiative cooling structures into temperature responsive carriers (eg phase change-oxides, thermonastic shape-memory alloys) and albedo adaptive photoluminescent finishing, with the twofold purpose to tailor radiative supercooling performance enough to minimize winter penalties and to give the desired colour finishing, finally allowing the sustainable upscaling of this research frontier. This approach would radically change the building physics paradigm, with the ambition of rethinking built environment into a fully-dynamic resilience, as only Nature can do. HELIOS will indeed analytically and experimentally identify the thermal-radiative physics of such skin, assessing its performance for indoor-outdoor human comfort and energy-efficiency. HELIOS bio-inspired radiative and photoluminescent skin will be indeed tailored and optimized for each dynamic boundary, as demonstrated through a disruptive building physics experimentally-validated balance and urban canopy model worldwide.

Keywords: urban heat island passive cooling energy efficiency smart building material building envelope smart pavement radiative cooling perovskite environmental comfort urban resilience
Renewable and safe Aromatic compounDs As Replacements for substances of concern (RADAR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Belgium,Germany,Netherlands,Denmark,Austria,Spain,France,Croatia
Call: Development of safe and sustainable by design alternatives (IA) (HORIZON-CL4-2024-RESILIENCE-01, 2024)
Start date: 2024-12-01
End date: 2028-11-30
Duration (months): 48.0
Total project cost (EUR): 15043285.0
EU funding (EUR): 13924216.39
Participants: 18
Project status: SIGNED

Fossil-based aromatic chemicals like phenol, bisphenol A (BPA), BPA derivatives and alkylphenols are produced on a million ton scale and are commonly used in surfactants, flame retardants and plastics. However, they also raise serious environmental and health concerns especially in applications that result in potential exposure to the body such as detergents, furniture, textile or food packaging. Therefore, this multidisciplinary EU project aims at developing renewable compounds as benign alternatives for current aromatic chemicals following the Safe and Sustainable-By-Design (SSbD) framework. The project will focus on the molecular design of novel biobased compounds as alternatives for substances of very high concern (SVHC) via an inventive catalytic biorefinery of biomass sides streams. New approach methodologies (NAMs) will be used for hazard assessment of the new chemicals in terms of human health and environmental toxicity. Machine learning models will be developed for the design phase and for the in-silico impact assessment of the novel chemicals. Successful products will be safe, follow the principles of green chemistry, demonstrate a lower carbon footprint than their petrochemical counterparts and will have a calculated life cycle and socio-economic impact. Formal SSbD reporting in RADAR will demonstrate the applicability of the framework and support EU policy. The selected RADAR chemicals will be upscaled to multi kg scale and investigated in industrial applications while they will be benchmarked against functional properties of standard flame retardant, surfactant or can coating materials. RADAR data will allow mapping of the substitution barriers in terms of supply, production cost and performance. To reach its goals, the RADAR consortium involves all relevant industrial actors along the value chain ranging from biomass refinery to chemicals production and brand owners in end markets supported by excellent knowledge institutions.

Keywords: biomass,biorefinery,lignin,in silico models,nam,bisphenol a,nonylphenol,hazard assessment,ssbd,flame retardant,surfactant,life cycle,socio economics,epoxy,can coating
Controlling spin angular momentum with the field of light (SPINFIELD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1499625.0
EU funding (EUR): 1499625.0
Participants: 1
Project status: SIGNED

Short pulses of light allow controlling electrons in solids with superb precision and outstanding speed, now reaching the sub-femtosecond timescale. Yet, our ability to act on the angular momentum of materials at these ultrafast time scales is surprisingly close to inexistent. This is because very little is known about direct, first-order coherent interactions between the electromagnetic field of light and angular momentum. Predictions show that these interactions are extraordinarily complex and comprise components of fundamentally different nature – originating from quantum many-body effects, relativistic quantum electrodynamics, or symmetry breaking. These coherent phenomena, however, have yet to be directly captured. The proposed research aims at unveiling this class of direct light-spin interactions for the first time. My strategy relies on the use of the shortest pulses of light available today – attosecond pulses – employed to probe systems which selectively enhance different components of the coherent response. We will establish spectroscopic schemes building upon mature state-of-the-art attosecond technology, providing clear-cut evidence of phenomena which are in the blind spot of current approaches. Two control scenarios will be explored – in the first one, ultrashort pulses will redistribute angular momentum among the system constituents, on sub-femtosecond timescales. In the second, the spin angular momentum of light pulses itself will be imparted to matter, thereby coherently controlling the magnetic and topological properties of materials. We aim to answer key fundamental questions reaching across several disciplines of physics. Because spin angular momentum in solids is intimately related to magnetism and topology, SPINFIELD will also provide a decisive blueprint guiding the design of a new generation of devices that can be optically controlled and switched at unrivaled speeds.

Keywords: attosecond,spin angular momentum
From Insightful Science to Innovative Health: Strengthening Translational Capacity and Talent Interoperability in Vaccine and Biologic Research & innovation (VISION)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Tunisia,Ukraine,Serbia,France,Spain,Belgium
Call: Fostering balanced brain circulation – ERA Talents (HORIZON-WIDERA-2022-TALENTS-03, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 2706416.25
EU funding (EUR): 2706416.25
Participants: 8
Project status: SIGNED

Following the COVID-19 pandemic, biologicals and vaccines became regarded as salient pillars for disease prevention and control. However, strengthening preparedness for and response to health emergencies request more commitment and intersectoral cooperation between academia and industry to set up efficient strategies against diseases, whether through surveillance, detection, diagnosis, prevention, or treatment. VISION (Vaccine & bIologics reSearch & innovatION) intends to implement an intensive intersectoral and bidirectional knowledge/know-how transfer programs in order to reinforce vaccine and biologics development capacities with manufacturing, upscaling, or delivery capabilities among a consortium with Institut Pasteur de Tunis (Tunisia), Darnitsa (Ukraine), Torlak Institute (Serbia) and Connect’innov (Tunisia) as academic (AC) & non-academic (NA) widening members; Institut Pasteur (France) and Center for Genomic Regulation (Spain) as academic research non widening (NW) organizations; Merck (France) and Quantoom (Belgium) as NW&NA partners. VISION comes as a critical lever for R&I ecosystem feeding post-pandemic needs and matches the WHO mRNA Transfer initiative aiming to enhance widening production capacities and help achieving a comprehensive health coverage towards Sustainable Development Goals. VISION will in fine streamline the discovery, testing and production of biologics and vaccine candidates including mRNA-based technologies. VISION's main objectives are threefold: (i) endow Widening Talents with advanced knowledge and skills in Vaccine and Biologics Development, (ii) promote more impactful collaboration through training and mobility between AC and NA sectors towards an efficient high-performance translational R&I environment with an Open Science pillar, and (iii) ambition to make widening members a regional flagship for excellence in innovative research with increased biobusiness and entrepreneurship capacity and openness to the socio-economic sector.

Keywords: vaccine and biologicals development,talent upskilling,intersectoral mobility,knowledge transfer,brain circulation
Sustainable and HIgh Performance MEmbranes via iNTerfacial complexation (SHIPMENT) (SHIPMENT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-05-01
End date: 2023-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Membrane technology is a very sustainable approach to separation, as it requires much less energy than conventional separation approaches. But the sustainable image of membranes becomes substantially tarnished when you realize that nearly all membranes are prepared using large quantities of toxic and unsustainable aprotic solvents (NMP, DMF etc). To secure the future of membrane technology, it becomes critical to develop more sustainable approaches to membrane fabrication. An Aqueous Phase Separation (APS) technique has recently been proposed by the PI as a green and sustainable alternative to the currently dominant non-solvent induced phase separation (NIPS) process.[1–4] APS utilizes polyelectrolytes such as poly(sodium 4-styrenesulfonate) (PSS), poly(diallyldimethylammonium chloride) (PDADMAC), poly(allyl amine hydrochloride) (PAH), and polyethyleneimine (PEI) to obtain sustainable polyelectrolyte complex (PEC) membranes in a completely water-based process. The structure and morphology of these APS membranes can easily be controlled to produce excellent separation properties. Although APS membranes show high solute retentions, the water permeability is much lower than NIPS membranes now utilized for the same application. This originates from the fact that the separation is performed by the same material that gives the membrane its mechanical strength and porosity. As a result, the water permeability is compromised when utilizing dense and mechanically strong membranes, but mechanical properties are poor when more swollen materials are used that provide a high water permeability. The lower water permeability of the existing APS membranes is now the major obstacle preventing their commercial production and large scale industrial acceptance. Herein, we propose a modification of the APS procedure by employing Interfacial Complexation (IC) during the phase inversion step to produce composite membranes that ultimately lead to the required high performances.
HYDRIDE: Hydrogenase Driven H2 production through Design and Evolution (HYDRIDE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: CLOSED

Climate change is shaping up to be the greatest existential threat that humanity has ever faced. To combat climate change and the corresponding energy crisis, greenhouse gas emissions must be substantially reduced by 2030 while developing non-fossil future fuel alternatives, such as hydrogen. Hydrogen is highly versatile as it can be used in both fuel cells and electricity production. However, currently >95% of the global hydrogen production is fossil fuel-based and not sustainable. Biotechnological hydrogen production is realized through microorganisms harbouring hydrogenases and represents a promising alternative to expand the proportion of sustainable hydrogen within the global budget. However, the utilization of these enzymes is limited by various mechanisms, including inhibition by oxygen, making biohydrogen in its current state not economically sustainable. HYDRIDE is an interdisciplinary study aiming to overcome the oxygen sensitivity of [FeFe]- hydrogenases by designing and evolving high-performance hydrogenase enzymes. This will be achieved by 2 major steps: 1) Using sequence data, ancestral enzymatic scaffolds (AEC) of [FeFe]-hydrogenases will be designed and characterized towards their ability to produce hydrogen, their oxygen sensitivity and active site characteristics. AECs have been shown to provide good starting points for laboratory evolution. Thus, these ACEs will be 2) evolved to overcome low hydrogen production under oxygen exposure using a high-throughput selection system. Consequently, HYDRIDE will tackle one of the major bottlenecks for the utilization of [FeFe]-hydrogenases, paving the way for sustainable and economical biotechnological hydrogen production. While addressing two societal UN sustainability goals, the knowledge gained from this study will substantially advance other scientific fields, aiding e.g., the development and design of artificial catalysts.

Keywords: hydrogen,hydrogenases,directed evolution,enzyme design,biohydrogen,directed evolution