Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Strengthening Omics data analysis capacities in pathogen-host interaction (PHINDaccess)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Germany,Spain,Tunisia,France
Call: Twinning (H2020-WIDESPREAD-05-2017-Twinning, 2017)
Start date: 2018-10-01
End date: 2022-09-30
Duration (months): 48.0
Total project cost (EUR): 989468.75
EU funding (EUR): 989468.7
Participants: 5
Project status: CLOSED

The advent of high-throughput approaches has revolutionized the way we address biological circuits and their complex interrelation during infectious processes. Deciphering the molecular mechanisms underpinning pathogen-host interaction (PHI) is now dealt with in the context of systems biology, which is critically dependent upon our ability to analyze Omics data (whole genome sequence, whole exome sequencing, RNA-seq, proteomics, etc.) derived from both the pathogen and its host. The Institut Pasteur de Tunis (IPT) has for long been working at the interface of PHI, aimed at better delineating critical aspects governing pathogenicity and disease transmission. Through this twinning project, referred to as PHINDaccess (Pathogen-Host INteraction Data access), IPT intends to empower its capacities to efficiently exploit the extraordinary potential of Omics data generated in the context of PHI studies. PHINDaccess should in fine streamline the discovery of critical regulatory interactions, thus allowing for the rational identification of putative biomarkers, drug targets and/or lead vaccine candidates. PHINDaccess main objectives are threefold: (i) endow IPT researchers with advanced knowledge and skills in Omics science, (ii) provide IPT with an efficient high-performance bioinformatics environment, and (iii) ambition to make IPT a regional flagship for excellence in innovative Omics research with increased networking and openness to the socioeconomic sector. To achieve this goal, IPT will twin with world-renowned European centers, namely the Institut Pasteur, the Max Planck Institute for Molecular Genetics, the Center for Genomic regulation, and the Robert Koch Institute, with whom previously EC-funded collaborations have been successfully achieved.

Keywords: pathogen host interaction,omics,bioinformatics,systems biology,infectious diseases control,networking,scientific excellence,innovation,smart specialization,open science,ethics
GreenApes Sustainability Software Service: Employee Engagement for Eco-innovation (ECO - ENGAGE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The ECO-ENGAGE solution will support companies to achieve Corporate Social Responsibility (CSR) and sustainability targets (mainly energy and resource efficiency), through a novel composition of social networking and gamification solution, capable of stimulating employees’ eco-friendly activities. The project implementation will impact on the optimization of resources, the reduction of the overall environmental impact or organizations and consequent mitigation of climate change. The strength of ECO-ENGAGE solution relies on: 1) Employees-centric sustainability platform, in which employees do not perceive sustainability as a corporate prescription but rather as a contribution to a larger, global sustainability project; 2) Team achievement approach through incentives for the adoption of sustainable behaviors, tangible rewards, gamification techniques for engagement, the creation of a social sustainability profile; 3) Appealing user-friendly interface that turns natural human curiosity into a valuable learning experience. Overall, the innovative ECO-ENGAGE project will benefit: 1) Targeted clients. With the implementation of the greenApes Employee Engagement Platform (EEP), large organizations can obtain a ROI of up to 50% already in the first year . Considering the huge economic, commercial and Environmental advantage Enel Green Power already signed an agreement to adopt the solution once in the market (5000 employees will be involved). 2) The Proponent. With an estimated ROI of 88% in 3 years the project has the potential to boost company's growth. The current technology readiness level of ECO-ENGAGE project is TRL 7, and it aims at reaching TRL 8-9 by Phase 3. The financing from Phase 1 will provide ECO-ENGAGE insights on the market and on tools for marketing and structuring a sales force

Keywords: sustainability behaviour,energy saving,environment,gamification,corporate green behaviour
The CYBERnetic LowEr-Limb CoGnitive Ortho-prosthesis Plus Plus (CYBERLEGs Plus Plus)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Iceland,Italy,Italy,Belgium,Belgium,Slovenia
Call: Advanced robot capabilities research and take-up (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2021-04-30
Duration (months): 52.0
Total project cost (EUR): 4621125.0
EU funding (EUR): 4285200.0
Participants: 7
Project status: CLOSED

The global goal of the CYBERLEGs Plus Plus project is to validate the technical and economic viability of the powered robotic ortho-prosthesis developed within the framework of the FP7-ICT-CYBERLEGs project as a means to enhance/restore the mobility of transfemoral amputees and to enable them to perform locomotion tasks such as ground-level walking, walking up and down slopes, climbing/descending stairs, standing up, sitting down and turning in scenarios of real life. Restored mobility will allow amputees to perform physical activity thus counteracting physical decline and improving the overall health status and quality of life. This consortium will pursue the achievement of the global goal by addressing four specific innovation objectives. 1) Further developments of the existing CYBERLEGs hardware modules, namely the 2-degree-of-freedom active transfemoral prosthesis, the active wearable orthotic device, and the wearable sensory apparatus. 2) Further developments of the existing multi-layered CYBERLEGs control system, to enhance its reliable use in real-life scenarios. 3) Carrying out two multi-centre clinical studies, that validate the therapeutic potentialities and the economic viability of a robotic ortho-prosthesis which restores the amputees’ locomotion abilities in scenarios of activities of daily living. 4) Implementation of a 3-phase strategy to foster the start of the market exploitation within the time frame of the CLs++ project. This proposal focuses on the demonstration in an operational environment (TRL=7) from both the technical and economic viability view point of a modular robotics technology for healthcare, with the ultimate goal of fostering its market exploitation. The proposals involve players from academia, end users, as well as robotics and healthcare industry. Therefore this proposal fits the specific challenge of the scope c of the call H2020-ICT-25-2016-2017.

Keywords: robotic lower limb prosthesis,robotic lower limb orthosis,transfemoral amputees,atherosclerosis
Cosmology, Astronomy, and Religion in Medieval India (CARMI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-06-01
End date: 2019-05-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

CARMI proposes to study the friction between two cosmologies found in India in medieval times: the cosmological model used by the astronomical tradition of India, and the cosmology found in the Purāṇas, a group of texts sacred in Hinduism. In the Indian tradition, cosmology falls within the branch of knowledge known as jyotiḥśāstra, which has three divisions: saṃhitā (omens); horā (astrology); and gaṇita (the astral sciences, including astronomy and cosmology). With CARMI present, the Department of Cross-Cultural and Regional Studies will have experts in all three divisions, creating a unique research environment for the study of all aspects of jyotiḥśāstra. This will be particularly valuable for CARMI. Historically, the Indian astronomers rejected elements from the Purāṇas contradicting their model, but also incorporated compatible elements. With the astronomer Jñānarāja (1500 CE), this changed; he sought to create a synthesis between the two incompatible cosmologies. He maintained that the sacred Purāṇas could not be contradicted. At the same time, he needed a working science. So he re-interpreted passages from the Purāṇas. This approach had a significant impact on Indian astronomy. What were the dynamics that led to this approach? Why was it felt necessary to assert the authority of the Purāṇas within the Indian astronomical tradition? Through a careful investigation of Jñānarāja's sources, CARMI will have an interdisciplinary approach to the understanding of issues arising from the interaction of cosmology, on the one hand, and religion, on the other (that is, two separate subfields of Indology), in medieval India (ca. 1200 to 1500 CE) based on the analysis of primary Sanskrit sources.

Keywords: cosmology,astronomy,indian cosmology,indian religion,virodha parih ra,brahmasiddh nta,somasiddh nta,vasi hasiddh nta,romakasiddh nta,siddh ntasundara,j nar ja
Enabling the transferability of cycling innovations and assessment of its implications (Handshake)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Countries involved: Italy,Germany,Spain,Ireland,Italy,Germany,Belgium,Finland,Poland,Belgium,Latvia,France,Netherlands,Denmark,United Kingdom
Call: Increasing the take up and scale-up of innovative solutions to achieve sustainable mobility in urban areas (H2020-MG-2017-Two-Stages, 2017)
Start date: 2018-09-01
End date: 2022-08-31
Duration (months): 48.0
Total project cost (EUR): 4990283.27
EU funding (EUR): 4859093.75
Participants: 19
Project status: SIGNED

HANDSHAKE supports the effective take up of the integrated cycling solutions successfully developed by Amsterdam, Copenhagen and Munich, our Cycling Capitals and world-renowned cycling front runners, to our 10 highly committed Future Cycling Capitals, Bordeaux Metropole, Bruges, Cadiz, Dublin, Helsinki, Krakow, Greater Manchester, Riga, Rome and Turin. Our partner cities are combined in a composite working environment in which diverse geographical contexts, socio-economic conditions and planning cultures work toward the same goals, that is, delivering the desired cycling change. The project believes that effective transfer can happen only in the presence of: i) state-of-art body of knowledge on cycling policy and solutions; ii) sustaining transition processes; iii) motivating and supporting forms of mentorship. In HANDSHAKE this is ensured by the presence of 3 cycling planning champions, the employment of highly innovative methods brought together into a supportive and novel transfer cycle (including Bikenomics, Immersive Study Tours and Transition Management), and a mentorship programme that takes by the hand each participating city. The gathered team will cooperate to reach a number of strategic objectives: i) Inspire the creation or refinement of holistic cycling visions and concrete transfer approaches; ii) Foster the adoption of a multidisciplinary planning culture to empower the project process and consolidate future cycling policies and investments; iii) allow cycling to become a key element of urban transport; iv) Improve cycling modal share and safety; v) Leverage the potential of cycling as a critical congestion relief tool; vi) Leverage cycling to improve public health; vii) Foster economic growth. HANDSHAKE expects to improve cycling attractiveness by +52% and competitiveness by 17%, shift ca. 60.000 people to cycling with +34% in frequency of cycling use, 37,5% in accidents, traffic levels lowered by 6,34%, and CO2 savings of -3.706.000 kg CO2/year.

Keywords: cycling,effectiveness,inspiration,innovation,mentoring,commitment,knowledge exchange,complete transfer cycle,sustainability,economic trigger,people centred,bikenomics,modal shift
Synthetic Active Droplets Inspired by Life (ActiDrops)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-01-31
Duration (months): 60.0
Total project cost (EUR): 1491350.0
EU funding (EUR): 1491350.0
Participants: 1
Project status: SIGNED

Active droplets are made of molecular building blocks that are activated and deactivated by a chemical reaction cycle. In the activation, a precursor is converted into a building block for droplets driven by the consumption of fuel. In the deactivation, the building blocks react back to the precursor. In other words, active droplets emerge when fuel is supplied, but decay when fuel is depleted. Theoretical studies show active droplets all evolve to the same size. Another work predicts that the droplets can spontaneously self-divide when energy is abundant. All of these exciting properties, i.e., emergence, decay, collective behavior, and self-division are pivotal to the functioning of life. If we could engineer these behaviors in synthetic materials, we would obtain a better understanding of active assembly which is directly relevant to biology and the origin of life. I thus aim to synthesize active droplets and study their life-like properties. Two types of active droplets will be investigated; one type based on oil-molecules that phase separate in water, and one type based on cationic peptides in a complex coacervate with RNA. My team will develop reaction cycles that drive the droplet formation, thereby making them active. We will study their spontaneous emergence in response to energy, and disappearance when energy is scarce. Moreover, we study their collective behavior, like how they grow into one large droplet, or all converge to the same droplet volume. Finally, we test their division into daughter droplets. Our systematic approach will test how kinetic parameters, like the activation rate, affect the behavior of the droplets. The results will mark a massive step forward in the engineering of materials with life-like behaviors, which can also serve as experimental models for membrane-less organelles. We expect to elucidate mechanisms that could have played a role in the origin of life. Finally, our findings could form stepping stones towards a synthetic cel.

Keywords: self assembly,supramolecular chemistry,active materials,droplets,emulsion,active droplets
High-Precision Global Analysis of Color-Free LHC Processes at Small Recoil (COLORFREE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The Large Hadron Collider (LHC) at CERN collides protons at the highest energies. With the large datasets from Run 2 and the further increase expected from Run 3, the precision of LHC measurements will significantly improve over the next years. Color-free processes (for which the final state of the hard interaction is color neutral) are of central importance to several high-priority areas of the LHC precision physics program. Prominent examples are measurements of the W-boson mass, of the couplings of the Higgs boson, and searches for the elusive dark matter particles. The key innovation of COLORFREE will be to combine many different color-free processes in a new type of global analysis in which the dominant theory uncertainties are either eliminated or constrained by the data itself, thereby improving the theoretical precision up to an order of magnitude to the 1-2% level. In doing so, COLORFREE will unlock the full potential of existing and future precision measurements of color-free processes. This will be achieved 1) by exploiting and further developing a groundbreaking new method to reliably quantify perturbative theory uncertainties and their correlations, which was recently developed by the PI, and 2) by developing innovative new effective-field theory methods to account for all effects that are relevant at this precision but have been neglected so far. Important outcomes of COLORFREE will be: 1) Determinations of fundamental parameters at the highest possible precision, and stringent tests for possible effects beyond the Standard Model. 2) A new type of precision theory predictions with built-in uncertainties and correlations, which will solve a long-standing problem at the interface of theory and experiment. In particular, precision measurements often avoid theory limitations by relying on theory uncertainties to cancel between different control and signal regions, but until now have had no means to reliably quantify the remaining theory uncertainties.

Keywords: lhc precision physics,scet,effective field theories,resummation,theory uncertainties and correlations,w mass,higgs couplings,dark matter
Demonstration and launch of high performance, biodegradable, regenerated New Cotton textiles to consumer markets through an innovative, circular supply chain using Infinited Fiber technology (New Cotton)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Innovation actions
Countries involved: Germany,Finland,Finland,Türkiye,Sweden,Sweden,Slovenia,Netherlands,Netherlands,Portugal
Call: Innovative textiles – reinventing fashion (H2020-FNR-2020-1, 2020)
Start date: 2020-10-01
End date: 2024-03-31
Duration (months): 42.0
Total project cost (EUR): 8813414.6
EU funding (EUR): 6745801.25
Participants: 13
Project status: SIGNED

Every second, the equivalent of one garbage truck of textiles is landfilled or burned at a huge environmental and societal cost. Textile production is one of the most polluting industries, producing 1.2 billion tons of CO2e per year – more than international flights and maritime shipping. Apparel consumption is projected to rise to 102 million tons by 2030 – a 63% increase equivalent to more than 500 billion T-shirts. As a result, the challenges this project is targeting to solve are becoming even more critical. The textile industry - along with government officials, environmental organizations, and consumers - agree that it’s imperative to make a change towards sustainable production and consumption. There’s a will and an urgent call for change. Existing solutions cannot recycle the growing piles of discarded textiles. There hasn’t been a feasible alternative on the market that would be affordable, environmentally sustainable and provide the required mechanical properties and functionality. Infinited Fiber Company’s cellulose carbamate technology enables textile waste that is currently burned or landfilled to be turned into cost efficient, cotton-like fiber with superior qualities. The patented process can digest cotton rich textile waste (including mixed fibers) and other cellulose based waste feedstocks. The diverse feedstock range is a technological advantage diminishing the need for virgin raw materials. This project will demonstrate that circular, sustainable production and consumption can be a reality. Bringing together the whole circular textile value chain, we will demonstrate an approach where post-consumer waste textiles are recycled with the IFC technology into new fibers and textiles with considerably lower environmental impact while fulfilling brand and consumer performance requirements. In collaboration with leading global brands, the regenerated New Cotton textiles are converted to apparel and launched to consumers to validate their market.

Keywords: post consumer textile waste,chemical recycling,textile fiber technology