Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Role of the SIRT7-NPM-c-Myc pathway in lung cancer (SIRT7-LC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Lung cancer is the second cause of death due to malignancy and diagnosed patients rarely survive beyond two years. Thus, unveiling the molecular mechanisms underlying lung tumorigenesis is imperative for development of novel therapeutic approaches. The nucleolar protein nucleophosmin (NPM) plays critical roles in cancer progression and is often deregulated in human malignancies. NPM employs distinct mechanisms to control cancer cells growth including regulation of the proto-oncogene c-Myc, a transcription factor often aberrantly activated in lung cancer. Recent studies highlighted the fundamental impact of post-translational modifications in controlling NPM functions. NPM is a deacetylation target of Sirtuin 7 (SIRT7), a member of a class of NAD+ dependent histone/protein deacetylases collectively known as sirtuins. Deacetylation of NPM by SIRT7 is fundamental to control NPM subcellular localization and stimulate NPM-mediated cellular stress responses. SIRT7 also acts as a potent oncogene in different malignancies although through still poorly characterized mechanisms. Thus, SIRT7-LC aims to characterize the impact of the SIRT7-NPM axis on regulation of c-Myc pro-oncogenic activities and its impact on lung cancer cells proliferation in vitro and in vivo, as well as possible aberrant activation of this pathway in human lung cancers and its correlation with prognosis. Thus, SIRT7-LC may lead to identification of novel molecular mechanisms sustaining lung cancer growth that could be targeted for therapeutic interventions. Dr. Alejandro Vaquero, a world-leading expert in the sirtuins field, will supervise this project. His competence in the field together with my expertise in characterization of mouse models of diseases will undoubtedly ensure successful realization of the proposed project, expanding my scientific knowledge, increasing my visibility as scientist and contributing to my development as a fully independent investigator.

Keywords: sirtuins,sirt7,nucleophosmin npm,deacetylation,proto oncogene c myc,lung cancer
Cellular and molecular mechanisms of pancreatic beta-cell adaptation to pregnancy in large mammals. (betaPPreg)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

Pregnancy is characterized by the development of maternal insulin resistance and increased hepatic glucose production to provide sufficient glucose to be used as nutrient by the developing fetus. The maternal insulin-producing beta-cells expand to counterbalance the increased glucose levels and failure of this process can lead to development of gestational diabetes, which has great health implications for both the mother and the developing fetus. Yet, our knowledge on the mechanisms behind the pregnancy-induced beta-cell expansion in humans is limited. To address this knowledge gap, in the betaPPreg project, I will use the pig model as an ideal surrogate large mammal to study the mechanisms and identify physiological drivers of pregnancy-induced beta-cell expansion. First, I will identify the extent and the different cellular mechanisms of beta-cell adaptation in the porcine pancreas over the three trimesters of gestational time (~114 days) by histological analysis. To reveal the physiological candidates of beta-cell adaptation, I will perform untargeted metabolomics coupled with proteomics analysis of serum and pancreas at sequential temporal windows during gestation. This analysis will point to the significantly changed metabolites and growth factors that can be potentially involved in beta-cell expansion. I will perform a small-scale metabolite/growth factor screen in isolated neonatal porcine islets with the most regulated factors, to causatively link the metabolites/growth factors stimulating beta-cell expansion. The most promising candidates will be then tested in isolated human islets and human-derived ductal organoids to assess their translational potential as beta-cell proliferation/differentiation inducers and human therapeutics. Overall, the proposed project will greatly advance our understanding of beta-cell adaptation during pregnancy in large mammals and provide novel therapeutic candidates for gestational diabetes treatment.

Keywords: pancreatic beta cell expansion beta cell adaptation during pregnancy porcine pancreas
Automated Tumour Tissue Dissection. The missing link in molecular pathology (TISSECTOR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

By 2040, cancer cases are expected to reach 27.5 million worldwide. Transformative technologies in PCR and Next-Gen Sequencing are now a mainstay in Molecular Diagnostics to guide personalized cancer therapy based on the molecular profile of patient’s tumor specimen. The need to precisely select a region of interest (RoI) from tumor by TISSUE DISSECTION is a critical pre-analytical step for the sensitivity and specificity of molecular assays. Yet, tissue dissection workflow remains a painstaking, manual process based on subjective RoI mapping and a limited manual scraping precision. As a leading innovation in molecular pathology, Xyall redefines tissue dissection with an automated, digitally guided, fully embedded workflow. From digital annotation to robotic scraping, Xyall’s TISSECTOR technology is the missing link between Anatomical Pathology and Molecular Diagnostics. The high throughput, accuracy and traceability offered is to create a new gold standard for tissue dissection.
European Training Network on Integrating AI in Proteomics: From Data Acquisition to Translational Applications (ProtAIomics)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Germany,United Kingdom,Denmark,France,Austria,Sweden,Finland,Czechia,Switzerland
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 4635875.52
EU funding (EUR): 4635875.52
Participants: 24
Project status: SIGNED

ProtAIomiProtAIomics is a European Innovative Doctoral Network aimed at training the next generation of computational proteomics researchers by integrating advanced artificial intelligence (AI) methods with proteomics. Computational proteomics stands at the forefront of cutting-edge life science research, utilizing advanced data analysis and AI to decode the complex interplay of proteins in biological systems. Proteins, typically referred to as the workhorses of biological systems, are central to understanding cellular functions, disease mechanisms, the mode of action of drugs, and drug response. The network brings together 15 beneficiaries and 9 associated partners from diverse academic and non-academic sectors, including university hospitals, SMEs, and large companies, to tackle key challenges in the computational proteomics field. The network focuses on three main research objectives: (RO1) developing AI-assisted algorithms to maximize the extraction of high-quality information from raw mass spectrometry (MS) data; (RO2) creating advanced tools to transform this data into deeper biological knowledge through AI-driven models; and (RO3) applying this knowledge to generate actionable insights, such as precision drugs and clinical biomarkers, with a focus on advancing therapeutic applications. Through cross-disciplinary collaboration, ProtAIomics will bridge gaps in current proteomics research by enhancing data utilization, improving understanding of protein functions, and advancing AI tools for clinical applications. The network will provide comprehensive training, equipping doctoral candidates with exceptional AI application and development skills in an intersectoral, interdisciplinary and international setting, and improving their future employability. ProtAIomics is committed to fostering responsible research and innovation (RRI), ethics, effective science communication, proficient data management, and advance towards delivering solutions to societal challenges.

Keywords: computational proteomics,artificial intelligence,protein function,structural proteomics
Decoding the path to cellular variation within pathogen populations (switchDecoding)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 1999825.0
EU funding (EUR): 1999825.0
Participants: 1
Project status: SIGNED

Heterogeneity amongst isogenic cells is pervasive throughout biology. Recently developed single-cell omics approaches are beginning to systematically reveal the repertoire of functionally distinct cell subpopulations within metazoan tissues. Pathogens frequently encounter changing and often hostile environments. To adapt to these challenges unicellular pathogen populations also exhibit a large degree of cell-to-cell heterogeneity, which often affects the outcome of infections. Yet, despite the importance of this cell-to-cell variation, very little is known about the mechanisms that control the level of heterogeneity in pathogen populations or why some isogenic populations are more heterogeneous than others. The goal of switchDecoding is to unveil the path to cellular variation. To this end I will go beyond identifying and describing new subpopulations of cells and elucidate the molecular pathways that establish them and modulate the level of cellular heterogeneity. As a model I will study the mechanism responsible for creating heterogeneity in surface antigen expression in the unicellular parasite Trypanosoma brucei. Antigenic variation is a widely employed strategy by evolutionarily divergent pathogens to evade the host immune response. Using a multidisciplinary approach, I will develop and combine single-cell multi-omics, lineage tracing and CRISPR-Cas-based genome manipulation strategies to characterize the processes, pathways and molecules regulating antigen switching in T. brucei. A better understanding of the mechanisms affecting the level of heterogeneity within a pathogen population will enable us to better predict how pathogens adapt to environmental challenges, including those that lead to the emergence of drug resistance. In the future this knowledge will enable the development of novel intervention strategies: drugs that modulate cell-to-cell heterogeneity to facilitate the clearance of infections.

Keywords: antigenic variation,genome architecture
Multifunctional fibre-reinforced plastic composites with MXene layers (MIRACLES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Lithuania,Latvia,Slovakia,Czechia,Italy,Sweden
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 1039600.0
EU funding (EUR): 943000.0
Participants: 10
Project status: SIGNED

Fibre-reinforced plastic composites (FRPC) are widely used in advanced fields such as aviation, shipbuilding, wind energy, etc. FRPC structures, during exploitation, lose loadbearing capacity because of local damage, icing, water absorption and other factors. The specific objective of the MIRACLES fundamental research is FRPC with the tailored additional functionality of damage monitoring, de-icing, self-sensing, and moisture barrier protection. These functions are implemented using thin MXene-dopped coatings and (or) interlayers. Novel two-dimensional MXene nanoparticles uniquely combine high electrical conductivity and mechanical properties realised under the high alignment of the particles in thin coatings and (or) interlayers. The workflow in the project combines theoretical modelling and experimental research with nano-engineered technologies for validation, upscaling, and demonstrating. Novel eco-friendly methods of MXene delamination and exfoliation will be explored together with the possibilities of reagent recycling. An automated spray and print methods with precisely controlled nanoparticle quality will be explored. Layer sensitivity will be improved with the new technology using different nanoparticle and polymer configurations. New surface temperature annealing, antioxidants, and protective polymer coatings will be explored to increase stability further. The objectives and contributions to the impact will be achieved through 117 secondments for 205 person-months, homework, and other networking actions. The interdisciplinary and intersectoral consortium of six academic and four industrial partners from six EU countries has complementary expertise in Materials Engineering, Mechanical Engineering, and Chemical Sciences. By starting from TRL3, the project plans to grow forward to TRL6. The greatest impact of this innovation will be achieved by making FRPC structures safer, cleaner and cheaper.

Keywords: mxene,fibre reinforced plastic composite,local curing,de icing,self sensing,barrier properties
GREEN-X: Advancing Sustainable Polymer Innovation through Circular Feedstocks, Greener Materials, and Industrial Collaboration (GREEN-X)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Portugal,Greece,Germany,Slovenia,Netherlands,France
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2026-03-01
End date: 2030-02-28
Duration (months): 48.0
Total project cost (EUR): 432291.43
EU funding (EUR): 395790.0
Participants: 7
Project status: SIGNED

The Green-X project is vibrant community for transferring scientific, technological, and industrially relevant knowledge in polymer chemistry and engineering, to advance the implementation of more sustainable materials in the plastic and coatings industries. Secondments will unite intersectoral and interdisciplinary efforts to explore alternative carbon feedstocks – such as humins from biorefinery and polyester waste – transforming them into high-value aromatic functional chemicals and polymers. For this, the excellent academic partners – University of Aveiro (UAveiro), the Aristotle University of Thessaloniki (AUTH), the Ecole Nationale Supérieure des Mines de Paris (Mines Paris PSL) and Fraunhofer WKI (WKI) - will team up with the innovative industrial companies with a focus on sustainable products – Worlée Chemie GmbH (Worlée), AVANTIUM Renewable Polymers BV (ARNP) and KANSAI HELIOS (HELIOS). Another key aspect of Green-X is promoting of ‘green skills’ and labour market opportunities essential for transitioning to a circular economy and aligning with the European Green Deal and the United Nations’ Sustainable Development Goals (SDGs). Through secondments, workshops, and co-organisation of activities, GREEN-X will acquire critical skills to bridge the gap between fundamental research and industrial applications. This includes scaling biobased monomers and polymers for packaging and coatings, enhancing chemical recycling technologies, and setting the stage for market penetration of bio-based polymeric materials. Moreover, GREEN-X will use existing research infrastructures and specialised know-how to support innovation in the circular economy. This collaboration ensures that the knowledge exchange and innovation ecosystem extends beyond the project’s duration, as outlined in the Sustainability Action Plan, contributing to development of a greener and more sustainable economy through breakthrough technologies and a well-trained workforce.

Keywords: sustainable polymers,biobased monomers,chemical recycling,circular economy,green chemistry,european green deal,thermoplastics,thermosets,biomass
Simulating coastal HydrOdynamics and particle tRansport procEsses (SHORE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 1497100.0
EU funding (EUR): 1497100.0
Participants: 1
Project status: SIGNED

Beaches are eroding at many locations around the world and, with the pending climate change (sea level rise and increased storminess in Northern Europe), coastal erosion is expected to potentially worsen. State-of-the-art practical engineering models for predicting sand and particle transport struggle with the cross-shore processes (perpendicular to the beach), and they even have difficulties predicting the sign right (offshore transport vs. onshore transport), in an experimental setting where the boundary conditions are fully known. The shortage of state-of-the-art models also means that the spreading of microplastic particles, which are increasingly polluting the oceans cannot be predicted accurately. As a result, the future shape of the world’s coastal profiles and the fate of microplastic particles in the coastal region are largely unknown. SHORE aims to bridge this knowledge and competence gap and develop the first model capable of accurately simulating both on and offshore transport of sediments and microplastic particles without case-specific calibration. The new model will (1) break from central assumptions used in existing state-of-the-art models, (2) utilize integrated rather than local quantities and (3) include additional factors known to govern the physics in the complex region around the shoreline. The development of the novel model will be made possible by gathering a novel experimental database containing measurements across a wide range of scenarios and utilizing more advanced numerical models. These advanced models are too computationally heavy to be used to study morphology, but due to recent breakthroughs by my colleagues and I they can be used to study the governing processes. The model developed within SHORE will subsequently be used to answer questions of great interest to research and society, such as the effect of climate change on coastal profiles and microplastic hotspots.

Keywords: sediment transport waves coastal profiles cross shore processes numerical modeling
Bio-based Hydrogels by Click Chemistry for Cartilage Tissue Engineering (ClickBioGel)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

Cartilage injury afflicts over a million patients annually in Europe and it is a serious problem due to Europe's ageing population. Hydrogels are promising materials for cartilage tissue regeneration in case they are designed accordingly. The use of synthetic materials suffer from biocompatibility and toxicity problems while natural materials can have drawbacks such as low mechanical strength, limited types, insufficient integration with host tissues and easy contamination with bacteria due to high biocompatibility. ClickBioGel aims to fill this gap through fabrication of bio-based hydrogels for cartilage tissue regeneration using a ternary material system composed of collagen, hyaluronic acid and K-carrageenan to advantage from their synergetic effects, and the “Click” chemistry concept, particularly thiol-ene and Diels-Alder reactions, for the selective and high yield chemical crosslinking of the hydrogels under mild reaction conditions. Chitin nanofibrils will be dispersed in the hydrogel precursor for enhancing the mechanical properties as well as antibacterial and bioadhesive characteristics while RGD peptide will be attached on the hydrogels for cell-adhesiveness. The production of the hydrogels will mainly be in three categories as photocrosslinked hydrogels, 3-D printed hydrogels and light-free injectable hydrogels, which will allow the tunability according to the needs. In vitro cell viability, cytotoxicity and chondrogenesis performance of the hydrogels will be evaluated. With the support of my supervisor (Prof Sangermano), his infrastructure at Department of Applied Science and Technology, as well as the interdepartmental biomedical research centre and the multidisciplinary additive manufacturing research centre at Politecnico di Torino, the fellowship will train me on hydrogel synthesis, photocuring, 3D-printing and biological analysis and act as a pilot for my own ERC starting grant to be an independent researcher.

Keywords: photocrosslinked hydrogels,3 d printed hydrogels,light free injectable hydrogels,diels alder reaction,thiol ene reaction,click chemistry,cartilage tissue regeneration