Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Microfluidic multiplexed cell chips (MULTICELL)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Products and process engineering
Countries involved: France
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-02-01
End date: 2017-01-31
Duration (months): 60.0
Total project cost (EUR): 1494744.0
EU funding (EUR): 1494744.0
Participants: 1
Project status: CLOSED

There exist very few techniques for studying a group of cells containing a large number compared to a single cell but small compared to a whole tissue. This implies that statistics are exceedingly difficult to obtain from measurements of individual cells. Microfluidics provides a way to amend this by allowing ways to observe individual cells and automate such measurements. The aim in this project is to develop a cell manipulation platforms based on microfluidics techniques developed in our lab, while answering relevant biological questions. The first question concerns Sickle Cell Anemia, a genetic disease for which no treatment exists. We will study the polymerization of hemoglobin within red blood cells, as they are submitted to cycles of oxygenation and deoxygenation. Quantitative measurements of the response of the cells to oxygen variations will allow physiological conditions to be simulated, including in the presence of therapeutic candidates or other biological agents. The second question concerns the motility of adherent cells in a three-dimensional environment. This question will be to understand the migration of cells in a 3D gradient of chemo-attractant, as well as gradients of rigidity of the environment. This part will require the development of new technological tools which can later be applied to a wide range of biological problems. The long term aim is to replace the current tools of biological labs with miniaturized and integrated lab on a chip devices.

Keywords: microfluidics,biotechnology
Space-Time Methods for Multi-Fluid Problems on Unstructured Meshes (STIMULUS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Mathematical foundations
Countries involved: Italy
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-11-01
End date: 2016-10-31
Duration (months): 60.0
Total project cost (EUR): 918000.0
EU funding (EUR): 918000.0
Participants: 1
Project status: CLOSED

In this project we develop new algorithms for the solution of general nonlinear systems of time dependent partial differential equations (PDE) in the context of non-ideal magnetized multi-fluid plasma flows with thermal radiation. We will produce new high order schemes on unstructured tetrahedral meshes that are applicable to a rather general class of problems in general geometries, thus opening a wide range of possible applications in science and engineering. We will consider both, Eulerian methods on fixed grids and Lagrangian schemes on moving meshes to reduce numerical diffusion at material interfaces. A particular feature of our schemes is that they are high-order one-step methods based on local space-time predictors that allow using time-accurate local time stepping, i.e. each element runs at its own optimal time step. Even nowadays better than second order accurate 3D unstructured Eulerian methods are very rare, but there is still no better than second order accurate unstructured Lagrangian scheme available on general tetrahedral meshes. To develop these missing algorithms is the objective of our research project. A very challenging application that we have in mind is inertial confinement fusion (ICF) which is highly relevant for modern society and its increasing need for clean and inexhaustible energy. It is believed that early ICF experiments in the 1970ies failed because they did not reach the necessary critical pressure and temperature due to hydrodynamic instabilities in the flow. In this project we propose to design algorithms for simulating ICF flows with billions of high order elements on up to 100,000 CPUs of modern supercomputers. We will also propose active control strategies based on adjoint equations to reduce the hydrodynamical instabilities. Hence this project aims at providing next-generation numerical modeling tools for a possible future scenario of clean civil energy production via ICF.

Keywords: scientific computing,numerical analysis,unstructured meshes,high order finite volume and discontinuous galerkin methods,non-ideal multi-fluid plasma flows with thermal radiation for nuclear fusion
Tackling socioeconomic inequalities in smoking: learning from natural experiments by time trend analyses and cross-national comparisons (SILNE)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: Netherlands,Netherlands,Germany,Belgium,United Kingdom,Belgium,Spain,Italy,Lithuania,Sweden,Finland,Portugal
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-01-01
End date: 2014-12-31
Duration (months): 36.0
Total project cost (EUR): 2253420.0
EU funding (EUR): 1795000.0
Participants: 12
Project status: CLOSED

For any strategy aimed to reduce socioeconomic inequities in health in Europe it is vital to tackle the large and widening inequalities in smoking. However, there is only limited evidence on effectiveness of tobacco control policies in terms of reducing inequalities. Especially lacking are evaluations of the effects of policies that have actually been implemented in different European countries. In addition, no studies have assessed the role of “strategic drivers” such as social welfare or educational policies. The aim of the proposed project is to analyse various “natural policy experiments” within Europe with the aim to generate new empirical evidence on the effectiveness of possible strategies to reduce inequalities in smoking. The project has three parts. First, time trends in various European countries will be analyzed with the aim to assess whether changes in national tobacco control policies have influenced inequalities in smoking cessation among adults. Second, comparisons between European countries will be made with the aim to assess whether cross-national differences in specific tobacco control policies were associated with inequalities in smoking initiation among adolescents. These cross-national comparisons will also assess whether different types of educational systems are associated with inequalities in smoking initiation. Third, the project will review the published results of intervention studies, and integrate these with our results. The combined evidence base will be disseminated across Europe, especially among those who are involved in the development of tobacco control policies and health-in-all policies. This innovative project will develop comparative research into a new strategy for the evaluation of natural experiments, combining methods from different disciplines. Top researchers from different European countries will work together, and bring together four large international networks relevant to inequities in smoking.

Keywords: smoking,education,socioeconomic factors,policies,trends,international variations,experiments,evaluations,tobacco control,schools,europe
Phosphorus dynamics in low-oxygen marine systems: quantifying the nutrient-climate connection in Earth’s past, present and future (PHOXY)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Earth system science
Countries involved: Netherlands
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 1498000.0
EU funding (EUR): 1498000.0
Participants: 1
Project status: CLOSED

Phosphorus (P) is a key and often limiting nutrient for phytoplankton in the ocean. A strong positive feedback exists between marine P availability, primary production and ocean anoxia: increased production leads to ocean anoxia, which, in turn, decreases the burial efficiency of P in sediments and therefore increases the availability of P and production in the ocean. This feedback likely plays an important role in the present-day expansion of low-oxygen waters (“dead zones”) in coastal systems worldwide. Moreover, it contributed to the development of global scale anoxia in ancient oceans. Critically, however, the responsible mechanisms for the changes in P burial in anoxic sediments are poorly understood because of the lack of chemical tools to directly characterize sediment P. I propose to develop new methods to quantify and reconstruct P dynamics in low-oxygen marine systems and the link with carbon cycling in Earth’s present and past. These methods are based on the novel application of state-of-the-art geochemical analysis techniques to determine the burial forms of mineral-P within their spatial context in modern sediments. The new analysis techniques include nano-scale secondary ion mass spectrometry (nanoSIMS), synchotron-based scanning transmission X-ray microscopy (STXM) and laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). I will use the knowledge obtained for modern sediments to interpret sediment records of P for periods of rapid and extreme climate change in Earth’s history. Using various biogeochemical models developed in my research group, I will elucidate and quantify the role of variations in the marine P cycle in the development of low-oxygen conditions and climate change. This information is crucial for our ability to predict the consequences of anthropogenically-enhanced inputs of nutrients to the oceans combined with global warming.

Keywords: global marine phosphorus cycle,climate change,oceanic anoxia
High Temperature Electronics (HITME)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: United Kingdom,United Kingdom,Belgium
Call:  (SP1-JTI-CS-2010-04, 2010)
Start date: 2011-01-04
End date: 2014-04-03
Duration (months): 39.0
Total project cost (EUR): 1486090.4
EU funding (EUR): 901200.0
Participants: 4
Project status: CLOSED

The migration of electronic control units from the engine fan-case to the core would be considered a huge benefit for the engine designer, reducing interconnection complexity and system weight, simplifying assembly and maintenance and providing key nacelle aerodynamic and bypass flow improvements. However, today’s engine control electronics, typically mounted on the engine fan-case, operates to a maximum temperature in the order of 125 deg C. If the control electronics were to be migrated to the engine core environment, it would be subjected to steady-state temperatures in the order of 2500C, rising to 3000C during transient engine behaviour. In this environment, today’s electronic control units would exhibit inferior performance, reduced reliability and extremely short lifetimes. The prime aim of the HiTME project is therefore to develop a safety-critical electronic system which can operate reliability when installed in the severe engine core environment. Central to this objective, will be the development, to TRL6, of electronic components and material technologies along with smart thermal and packaging designs that make the concept feasible. In order to design a product capable of withstanding the high temperatures associated with an engine core installation, whilst still maintaining performance (accuracy) and life, fundamental advancement in key technological areas will be necessary. The following areas are seen as the underpinning building blocks that will ‘enable’ a new generation product that will form the core of the research activity. • Component Enhancement (HTSOI, SiC & Passive Components) • Thermal Design (Cooling Technologies) • Material Selection (Material Technologies) • Packaging / Installation Design (Novel Packaging) • Develop Test Methods (and Analyses)

Keywords: high temperature electronics,engine control unit,packaging,thermal management,material selection,validation methods,characterisation,robust,reliable,aerospace,htsoi,sic,passive components
GURNEY FLAP ACTUATOR AND MECHANISM FOR A FULL SCALE HELICOPTER ROTOR BLADE (PT656)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: United Kingdom,Italy,United Kingdom
Call:  (SP1-JTI-CS-2010-04, 2010)
Start date: 2011-05-01
End date: 2015-10-31
Duration (months): 54.0
Total project cost (EUR): 660614.84
EU funding (EUR): 371063.0
Participants: 4
Project status: CLOSED

Microtecnica SrL (MT) have brought together industry leading expertise to support the design and development of a full scale Active Gurney Flap (AGF) system. The team have a combination of relevant experience in blade actuation across a range of technologies together with significant capabilities in fundamental engineering analysis to support a comprehensive review of potential solutions. The proposal reflects the joint desire of offering a risk managed baseline approach as well as ensuring all potential candidate solutions are assessed as part of the initial development task. The consortium is lead by MT who provide the technical and programme management and the detail design and manufacture of the wind tunnel and whirl test hardware. MT will be supported by Microtecnica Actuation Technologies (MAT), University of Bristol and the “Politecnico di Torino” based in Turin. The team ensures a balance of technical depth together with a commitment and capability to exploit technology for commercial gain.

Keywords: actuator,helicopter flight control system,blades control,electro mechanical actuator
Target binders (TARGETBINDER)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: Germany,Germany,United Kingdom,Germany,Bulgaria,United Kingdom,Austria,Germany
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-01-01
End date: 2014-12-31
Duration (months): 36.0
Total project cost (EUR): 5553931.0
EU funding (EUR): 3988730.0
Participants: 10
Project status: CLOSED

We want to further develop our tools and technologies for high-throughput research, with the final goals being (I.) the particle-based combinatorial synthesis of 1 Mio different peptides on a glass slide for chemical costs of ~50€ (KIT, CBL, MS, TUV), and (II.) the labelling-free parallel readout of binding affinities by a variant reflectometric interference spectroscopy method for ~10.000 peptide spots per cm(+2) when staining the array with an unlabeled protein (BIA, KIT). These tools provide the basis (III.) for a standardized, fast, and reliable high-throughput procedure that we want to develop in order to find high-affinity peptide binders against any pharmaceutically interesting target protein. Such a procedure might have an important impact in medicine and in the biotechnology industry. In order to achieve this goal, we will use display techniques that in combination with high-throughput sequencing typically will identify ~100.000 putative peptide binders per target protein (ISO). These will be synthesized in array format to validate binding to the target protein by an independent method (PPP, DKFZ). Next, based on binders from initial screens, many variant peptides are synthesized in high-density array format for iterative screens (PPP, DKFZ, KIT), whereby massive parallel labelling-free detection of binders pinpoints higher-affinity binders (BIA). In order to validate our novel high-throughput procedure, (IV.) we want to find high-affinity peptide binders against relevant target proteins (delivered by APO and OXF), and test these binders in biological assays (OXF, APO).

Keywords: high-throughput screening,peptide arrays,combinatorial peptide synthesis,cis display,labelling-free detection,rifs,cancer cells,therapeutics
WIND TUNNEL TESTS FOR THE EVALUATION OF THE INSTALLATION EFFECTS OF NOISE EMISSIONS OF AN OPEN ROTOR ADVANCED REGIONAL AIRCRAFT (WENEMOR)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Ireland,Italy,France,Italy,Greece,Italy
Call:  (SP1-JTI-CS-2010-04, 2010)
Start date: 2011-09-01
End date: 2013-10-31
Duration (months): 26.0
Total project cost (EUR): 1999332.62
EU funding (EUR): 1429231.56
Participants: 7
Project status: CLOSED

In the 1980s, many research work was performed, manly in the US, on new propulsion technology, at that time named “prop-fan”, that have the objective to reduce significantly the fuel consumption. WENEMOR has been developed in response to the requirements described in the Clean Sky-ITD-GRA call for proposals referenced under SP1-JTI-CLEAN SKY-2010-4 and named “Aero-acoustic noise emissions measure for advanced Regional Open Rotor A/C configuration”. Trying to respond to this call with a well organized and optimized proposal, WENEMOR has put together a consortium of well recognized universities, a well known aeroacoustic wind tunnel company and some SME around Europe with specific competence on noise measurements and data analysis. WENEMOR will address the topic of the above mentioned Call for Proposal carrying-out aero-acoustic measurements in an open test section of a large low speed wind tunnel, on a complete reduced scale modular model of different configurations of an aircraft with installed open rotor systems, operating in both “pusher” and “tractor” modes. The aim of these tests will be the creation of an aeroacustic data base that will have two main applications: to characterize emitted noise and evaluate installation effects of these different configuration and to allow the validation of Alenia aero-acoustic simulation codes. The acoustic data coming from these tests will be analyzed both for far-field and near-field noise characterization. Fundamental Aeronautics Program of NASA’s Aeronautics Research Mission Directorate have started funding GE and Boeing for wind tunnel test programs on isolated open rotor propulsion system and on scale model of aircraft equipped with this kind of propulsion system in low-speed wind tunnel to simulate low-altitude aircraft speeds for acoustic evaluation. Also JU Clean Sky project have addressed the problem in different ITD: Sustained And Green Engines (SAGE), Smart Fixed Wing Aircraft (SFWA) and Green Regional Aircraft

Keywords: open rotor noise: aeroacoustic measurements,wind tunnel testing.
Pathways common to brain development and ageing: defining strategies for preventive therapy and diagnostics (DEVELAGE)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Austria,Spain,Netherlands,Italy,Germany,France,France
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-01-01
End date: 2014-12-31
Duration (months): 36.0
Total project cost (EUR): 3881830.13
EU funding (EUR): 2994137.0
Participants: 9
Project status: CLOSED

The increasing number of elderly people will have a major impact on the prevalence of age-related diseases, which will pose major challenges to keep health systems in Europe sustainable. Current knowledge is insufficient to identify the transition of normal brain ageing into Alzheimer`s Disease (AD)-like brain damage. Elucidation of the genes and pathways contributing to the earliest stages of AD pathology and associated neurodegeneration should be instrumental to allow intervention when the condition is still reversible. The aim of the DEVELAGE project is to characterise shared molecular pathways between early developmental processes in the brain and brain ageing. Our concept is based on the hypothesis that disorders of neural development contribute to age-related neurodegeneration, that developmentally essential proteins might have a role in neurodegeneration, and that neurodegeneration-related proteins and genes are important during the development of the brain. The DEVELAGE approach is unique in that it is brain tissue-based, derived from neuropathological diagnosis with detailed molecular analysis of the spectrum of developmental and ageing changes in the very same brain samples used for a comprehensive array of investigations in humans as well as in experimental models at genetic, epigenetic, transcription and protein levels. DEVELAGE contributes to the understanding of biological variation by examining relevant number of cases with different phases of ageing and neurodegeneration as well as developing brains with or without developmental disorders. Pathways examined in humans will be validated in animal models, including a non-human primate, and vice versa. The combination of human samples and animal models susceptible to experimental manipulation will promote the translation of clinically relevant data into experimentally testable predictions and promotes the exploitation of therapeutically relevant targets to reverse or halt disease progresssion.

Keywords: ageing,development,human brain,genomics,proteomics,transcriptomics,epigenetic,non-human primate model