Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SELF-sustained and Smart Battery Thermal Management SolutIon for Battery Electric Vehicles (SELFIE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Germany,Austria,Germany,Spain,Italy,Austria,Poland,Türkiye,Belgium,France
Call: Integrated, brand-independent architectures, components and systems for next generation electrified vehicles optimised for the infrastructure (H2020-LC-GV-2018, 2018)
Start date: 2018-12-01
End date: 2023-07-31
Duration (months): 56.0
Total project cost (EUR): 5831581.25
EU funding (EUR): 4999455.13
Participants: 11
Project status: SIGNED

Strong efforts would be required to drastically reduce the fossil dependency and the CO2 emissions reductions in the transport sector, in line with the 2011 White paper on Transport – i.e. a 20% reduction in the CO2 emissions by 2030 (relative to 2008 levels) and a 60% reduction by 2050 (relative to 1990 levels). Electrification of the transport sector offers EU the opportunity to achieve these long-term targets. The larger automotive industry has recognized the potential of electric vehicles (EVs) and there are large strides planned in building electric charging infrastructure – as announced by E.ON and Ionity about their investment plans for ultra-fast charging infrastructure. Right now, there’s no EV that can accept this charge rate, but several automakers are working on electric cars able to accept that kind of power. SELFIE makes its biggest impact here, ensuring that the EVs, in the not so distant future, are able to accept this high charge rate without reduction on battery lifetime, and to store the energy efficiently in their batteries with minimal losses. The overall objective is to develop and demonstrate a novel self-sustained compact battery system, consisting of: - A smart modular battery pack, which has excellent internal thermal conductivity properties, a refrigerant cooling system and thermal storage system (heat buffer) capable to absorb excess heat due to fast charging, and which is thoroughly insulated from the outside; - An advanced battery thermal management system capable to keep the battery temperature effectively within the optimal window and to prevent overheating (and battery degradation) due to fast charging. SELFIE will significantly increase user acceptance of EVs by enabling fast-charging; offering significant cost reductions and elimination of range anxiety compared to other propulsion technologies.

Keywords: battery systems,thermal management,energy efficiency,long driving range,costs reduction
Transcriptional targeting of pacemaker and conduction system gene therapy (PACE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-07-01
End date: 2021-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The problem: Ageing and age-related diseases cause degeneration of the cardiac conduction system (CCS) that creates and conducts the electrical impulse which drives the heart beat (pacing). The resulting slow heart rate (bradycardia) necessitates electronic pacemaker implantation in 500,000 patients yearly in Europe (direct costs of €3.4 billion). This current state-of-the-art treatment has significant limitations (dangerous complications, reduced quality-of-life) that, stemming from its design, may never be resolved. Regeneration of CCS function is conceptually superior and scientific discoveries, enabling CCS regeneration, were recently made. Closest to clinical testing are a variety of gene therapy-based strategies that can provide for biological pacing. Complementary strategies to repair conduction are also under development. The solution: To transit biological pacemaker therapies towards clinical testing it will be crucially important to optimize the gene delivery vectors with transcriptional targeting to the CCS. This will provide for more efficient and safer vectors that can be utilized in the context of biological pacing and repair of compromised conduction. The PACE project is designed to provide for final proof-of-concept in the development path, moving forward from scientific discovery towards clinical implementation and testing. As such the PACE project will optimize and validate the use of CCS-specific cis-acting regulatory modules (CRMs) to optimize transcriptional targeting to desired CCS components in the heart and validate these in vivo. The development and validation of these CCS-targeted vectors will importantly strengthen our IP-position, thereby supporting the business development efforts that are an integral part of the PACE project.

Keywords: gene therapy,biological pacing,transcriptional targeting,cis acting regulatory modules
Schobers, Mutations and Stability (SCHEMES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Belgium
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1015047.5
EU funding (EUR): 1015047.5
Participants: 1
Project status: SIGNED

Mirror symmetry is a manifestation of string theory that predicts a certain symmetry between complex geometry and symplectic geometry. Mirror symmetry is justified on physical grounds but makes nonetheless strong and testable predictions about purely mathematical concepts. A celebrated example is the prediction by physicists of the number of rational curves of a given degree in a generic quintic threefold which went far beyond classical enumerative geometry. The main actor in this proposal is the "Stringy Kähler Moduli Space" which is the moduli space of complex structures of the mirror partner of a Calabi-Yau manifold. The SKMS is not rigorously defined as mirror symmetry itself is not rigorous, but in many cases there are precise heuristics available to characterize it. Mirror symmetry predicts the existence of an action of the fundamental group of the SKMS on the derived category of coherent sheaves of a Calabi-Yau manifold. This prediction has only been verified in a limited number of cases. We will attempt to confirm the prediction for algebraic varieties occurring in geometric invariant theory and the minimal model program. Our main approach will be the construction of a perverse schober on a partial compactification of the SKMS. The existence of such a schober does not only confirm, but also clarifies the predicted action as it is now becomes the result of ``wall crossing'', i.e. moving outside the SKMS itself. To reach our objective we will approach the SKMS from different angles, most notably through its relation with the moduli space of stability conditions.

Keywords: stringy k hler moduli space,moduli space of stability conditions,perverse schobers
OmniBot: Artificial Intelligence and Natural Language Processing Bot platform (OmniBot)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In the digital age the online channel is very important for lead generation: that is why chat-bots and Virtual Digital Assistants can become one of the most important channels. Chat-bots and VDAs are platforms that simulate a real conversation with users in written or spoken form by using artificial intelligence. Most of the available chat-bot platforms are limited in text, written and voice recognition. If they are not supported by AI, they are not able to identify the context and to remember conversations. Additionally, most platforms support a limited number of conversation domains. Platforms supporting custom domains, coming with high additional costs, require a lot of training data like chat logs, which are often not present or not sufficient. OmniBot is an Artificial Intelligence and Natural Language Processing Bot platform for designing and integrating Virtual Assistants. Through the use of the OmniBot platform components, OEMs and end customers can quickly start with simple limited task bots for initial functional deployments and evolve to more complex, conversational, voice enabled multi-task bots and virtual assistance. OmniBot provides a complete SDK providing all documentation, tools, templates and libraries for multiple platforms required for building and integrating scalable enterprise ready virtual assistants: this speeds up the bot integration process and reduces costs and complexity while increasing productivity and quality. OmniBot seeks funding to conduct a feasibility study to prove technical and commercial viability, conducting an analytical exercise to position the product. The objective is to test the economic viability of the platform among a larger pool of potential clients (user -acceptance), and to assess if the chosen commercialization approach will be conducive of the projected growth on the European level.

Keywords: virtual assistant,chatbot
Investigation of the underlying resilience and physiological adaptive response of the bona fide Cypriot indigenous grape cultivar cv. ‘Xynisteri’ to climate change (REXyCLIMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Cyprus
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-23
End date: 2024-03-22
Duration (months): 24.0
Total project cost (EUR): 157941.12
EU funding (EUR): 157941.12
Participants: 1
Project status: CLOSED

The adverse effects of increasingly warm and dry growing conditions are already pushing traditional and new-world wine-growing regions to their limits,. Since the grape-growing potential of their long-established cultivated grape varieties - and consequently the often strictly regulated quality and typicity of their wines - relies on the mesoclimate of their terroir sustaining a high temporal stability, climate change becomes a major threat. Among the adaptation measures considered, the most urgent is the adoption of climate-resilient grapevine varieties. Certain indigenous varieties found on the island of Cyprus, a natural “open lab” of warm and dry climate viticulture, have been reported to have a very high heat and drought tolerance and deserve consideration for cultivation outside their native region of production. However, their resilience remains yet to a large extent scientifically unexplored. To this end, the researcher will carry out a fellowship to investigate the underlying resilience and physiological adaptive response of the bona fide Cypriot indigenous grape cultivar cv. ‘Xynisteri’ to climate change, with an aim to support with sound scientific data its suitability as a variety to be used as a long-term adaptation measure, from countries where their viticulture is already negatively impacted by increasingly warm and dry growing conditions. The fellowship will be carried out in Zambartas Wineries Ltd as the Host Institution, a pioneering SME tightly aligned with regional Research Units, with targeted secondments at leading in the field Institut des Sciences de la Vigne et du Vin, France and University of Tuscia, Italy. The interdisciplinarity and intersectionality of the proposed project will provide the researcher with a unique opportunity to broaden her knowledge/skills and acquire a truly multidisciplinary methodological scientific perspective of an emerging field like viticulture, allowing her to seek a permanent senior position in viticulture R&D.

Keywords: horticulture,viticulture,berry quality,ripening,climate change,stress resilience,crop adaptation
New geomodels to explore deeper for High-Technology critical raw materials in Alkaline rocks and Carbonatites (HiTech AlkCarb)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Namibia,Czechia,United Kingdom,Virgin Islands, British,United Kingdom,Denmark,United Kingdom,United Kingdom
Call: New sustainable exploration technologies and geomodels (H2020-SC5-2015-one-stage, 2015)
Start date: 2016-02-01
End date: 2020-01-31
Duration (months): 48.0
Total project cost (EUR): 5395296.0
EU funding (EUR): 5395296.0
Participants: 14
Project status: CLOSED

Five of the 20 raw materials identified by the European Commission as critical are commonly found in association with alkaline rocks and carbonatites (heavy and light rare earth elements, niobium, fluorspar, and phosphate). Other elements increasingly important for ‘hi-tech’ applications, and found in these rocks include hafnium (Hf), tantalum (Ta), scandium (Sc) and zirconium (Zr). In fact, there is a greater chance of a carbonatite complex having resources economic to mine than any other rock type (about 20 active mines in ca. 500 known carbonatite complexes). Less than 3% of critical raw materials supply is indigenous to the EU. However, deposits are known and exploration is ongoing in parts of northern Europe. In central and southern Europe the presence of abundant alkaline volcanic rocks indicates the likelihood that deposits exist within about a km of the surface. This project will make a step-change in exploration models for alkaline and carbonatite provinces, using mineralogy, petrology, and geochemistry, and state-of-the-art interpretation of high resolution geophysics and downhole measurement tools, to make robust predictions about mineral prospectivity at depth. This will be achieved through studies at seven key natural laboratories, combined with Expert Council workshops. The results will be incorporated into new geomodels on multiple scales. In contrast to known deposits, Europe is well endowed with expertise. The project brings together industry partners involved in exploration, geophysics and environmental assessment with two geological surveys, a major museum and five universities. The results will make Europe the world leader in this specialist area. They will give the four SME industry partners world-leading expertise to develop and expand their businesses, transferring their business expertise from Africa to Europe. The project will help give European ‘hi-tech’ industry the confidence to innovate in manufacturing using critical raw materials.

Keywords: critical metals,carbonatites,alkaline rocks,geophysics,geology,mineralogy,geochemistry
Single molecule sequencing and biophysical properties of oxidized genomic DNA using magnetic tweezers. (EpiSeq)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Next-generation DNA sequencing technologies are at the core of modern molecular biology and are rapidly entering the technological arsenal for personalized medicine. The recent explosion of sequencing technologies has provided researchers with various solutions to fit their sequencing needs, with a large spectrum of costs and limitations. However, most sequencing methods use enzymatic duplication of DNA to generate a strong enough sequencing signal. Therefore, chemical modifications potentially present on native bases are lost, and with them, an entire level of epigenetic information about. Although some workarounds are emerging, they are indirect, costly, and not yet amenable for the targeted sequencing of a given native genomic locus or biophysical analysis of the modified DNA. Given the need to understand the epigenetic layer of genetic information, I propose to develop a reliable and cheap method to map, at the single-molecule resolution, the epigenetic status of a genomic DNA locus of interest. This will be achieved through biochemical capture of this locus using CRISPR/Cas9 technology, and its epigenetic sequencing via single-molecule manipulation by magnetic tweezers. In addition to identifying the nature and the position of the modified bases at a given genomic DNA locus, I will use this magnetic tweezer technology to address fundamental questions about the effect of epigenetic modifications on the biophysical properties of DNA (formation of DNA structures and protein interactions). Specifically, I will focus on 8-oxoguanine, for which there is increasing interest since it is a hallmark of degenerative pathologies like cancer or Alzheimer’s Disease, and since it has recently entered the known epigenetic arsenal. This project has great potential applications in medical diagnosis. It will give me a first-hand experience in developing a cutting-edge technology, which will be of great benefit to my future independent research career.

Keywords: epigenetic sequencing,magnetic tweezers,8 oxoguanines,next generation sequencing,medical,diagnostic tool development,crispr,cas9
Anthropologies of Extortion (EXTORT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Switzerland,Norway,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2026-12-31
Duration (months): 72.0
Total project cost (EUR): 2495250.0
EU funding (EUR): 2055718.75
Participants: 6
Project status: SIGNED

Extortion had come to occupy a quintessential position in the global imaginary of mafia-type-criminal organizations. Yet it is also increasingly present beyond clandestine criminal networks and is becoming a normalised profitable source of livelihood and governance and a key visible social relation in many parts of the world. Systematic research on and explanatory models for the apparent expansion and rountinisation of extortion in everyday life (including cyber-extortion) are currently lacking. Timely, the project sets up extortion as an object of anthropological inquiry and charts the first comprehensive cross-cultural account of extortion in social life across South and East Asia, the Americas, Africa and Europe. The proposed program of work consists of 5 main components: 1) Primary research on ‘offers that cannot be refused' across different domains of life in and across 22 settings; 2) Analytical and theoretical development in the study of power, consent and organized crime; 3) Methodological innovation by conducting a simultaneous cross-national ethnographic research and adding a South-to-South comparative angle in an area dominated by single case studies and a focus on the Global North; 4) Capability enhancement by forging an international network of scholars in the emerging field of the anthropology of crime and supporting the careers of the project's 5 Post-docs; 5) Policy relevant research in the fields of violence and consent, organized crime, informal economy and development. The study capitalises on previous research and skills of the PI in the cross-cultural study of bossism, politics and kinship and 'mafias' in the global South. Research will be embedded in anthropology but informed by empirical and analytical questions relevant to criminology, political science, economics and development studies.

Keywords: violence force,intimidation,consent,protection,power,informal,criminal economies,governance,organized crime
Development of novel technological approaches for a low-cost and reliable characterization of CROP Yield QUALity Traits of target crops grown under Changing Environmental Conditions (CropYQualT-CEC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria,Spain,Spain,Spain,Belgium,China,United States,United Kingdom,Japan,Chile
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-10-01
End date: 2026-05-31
Duration (months): 68.0
Total project cost (EUR): 1163800.0
EU funding (EUR): 1071800.0
Participants: 11
Project status: SIGNED

The expansion of world population requires the development of new strategies and tools for agriculture to ensure that high levels of production will accommodate the needs of world population by developing a highly productive and resource efficient agricultural systems. To that end, it is necessary to provide current breeding programs with improved methodologies (traits and protocols) for phenotyping together with a deeper knowledge of the molecular and metabolic mechanisms that modulate plant response to abiotic constraints in terms of yield and quality. Therefore, the development of new technological approaches, such as multispectral sensors and near-infrared reflectance spectroscopy (NIRS) is critical to deliver new tools for efficient breeding programs and in field management of crops. The current project has five main objectives: 1st objective is to investigate how will crop (wheat, rice, soybean, maize and quinoa) production and quality will be affected by the environment. 2nd objective is to identify the best adapted cultivars and molecular markers conferring a better grain yield and quality. 3rd objective is to investigate what phenotyping and molecular traits can better inform on crop yield and resource (water, nutrients, radiation) use efficiency. 4th objective is to develop the use of different remote sensing at field and labs levels as strategic tools to determine yield value. 5th objective will be the development of models. The result will be to build on the strong existing research network of 5 EU academic, 5 non-EU academic institutions and 2 firms. The project pursues the main objective of generating a common solid knowledge basis arising from the fruitful cross-sectorial synergy between forefront research Centers in precision agriculture and industry, in a cross-fertilization multidisciplinary approach that will provide new tests and methodologies (or improve existing ones) to assess. In this proposal, funding is requested for all TC partners.

Keywords: resource efficient agricultural systems,multiespectra technology,nirs technology,phenotyping,rice,soybean,quinoa,water stress and wheat