Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Let the music move you: involvement of motor networks of the brain in music processing. (MUSICMOVES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-09-01
End date: 2013-08-31
Duration (months): 24.0
Total project cost (EUR): 200049.6
EU funding (EUR): 200049.6
Participants: 1
Project status: CLOSED

Previous work has shown an intricate connection between music processing and movement in the brain. This overlap is also present for imagined music, and may as such be applied to existing imagery-based movement rehabilitation paradigms. In the following proposal we outline two main questions. The first concerns the extent of the involvement of motor areas during music processing in various modes, namely perception, auditory imagination, auditory-motor imagination and observation. Common and separate brain activation patterns will be assessed using fMRI. The second question addresses the effects of imagery training paradigms on plastic changes in the brain, and the effect of cuing during this training. Pre- and post training fMRI will be measured as well as the behavioral output of the training. These questions will address unanswered issues that are relevant to existing movement rehabilitation paradigms. Additional to furthering our knowledge of imagery mechanisms in the brain, the results will be directly applicable to the clinical arena, as well as training in high-level skill acquisition.

Keywords: neuropsychology,cognitive science
The subnuclear relocation of promoters during development, and following stress induction in C. elegans (WORMPROLOC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-01-01
End date: 2014-05-07
Duration (months): 24.0
Total project cost (EUR): 180101.6
EU funding (EUR): 180101.6
Participants: 2
Project status: CLOSED

During development and cellular differentiation, cells acquire specific fates by regulating spatially and temporally the expression of certain groups of genes. This correlates with drastic changes in the 3D organization of the genome. A recent discovery from the Gasser lab has demonstrated that in differentiated cells of C. elegans, tissue-specific promoters relocate inward the 3D nuclear space when activated, and maintain this subnuclear position in a tissue-specific manner into adulthood. Another interesting finding is the relocation of heat-shock promoters toward the nuclear periphery after their induction. Altogether, the data strongly suggests a link between the subnuclear relocation of specific promoters and cellular processes. However, the exact purpose of these chromatin movements is unclear and so is the underlying mechanism, including the responsible components. Therefore, this project aims to understand the mechanism and function of the subnuclear relocation of promoters during development, and following stress induction in C. elegans. This proposal will focus first on the identification of molecular and genetic elements that may be involved in this mechanism. Second, we want to understand how the candidate components we will identify effect the subnuclear promoters' relocation, and understand for the first time the relevance of this kind of chromatin reorganization. We combine genetic manipulations, advanced biochemical methods that we will need to develop and quantitative live imaging approaches to address these questions. The work is proposed to be carried out under supervision of Prof. Susan Gasser, at the FMI institute which offers state-of-the-art facilities and provides excellent multi-disciplinary training and collaboration opportunities, thus providing the ideal environment for a successful postdoctoral stay. This postdoc experience will mean switching fields and countries which will play an essential role in my professional growth.

Keywords: c.elegans,differentiation,chromatin,stress-response,transcription,natural sciences
Dissecting the regulation of lateral root formation by phosphate (EMPHOS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-10-04
End date: 2012-10-03
Duration (months): 24.0
Total project cost (EUR): 30000.0
EU funding (EUR): 30000.0
Participants: 1
Project status: CLOSED

Phosphate is an essential nutrient that is present in soils at low concentration with poor mobility and therefore represents a limiting factor for plant growth. The exponential demand of phosphate as a result of world population increase (50% by 2050) could lead to a world shortage of phosphate in a near future. The EmPhos project aims at characterising how plants perceive and adapt their root architecture to low phosphate concentrations. We will dissect and model the auxin regulation of phosphate response using innovative tools (Strand 1) and identify new genes responsible for the increase of lateral root number in response to phosphate starvation (Strand 2). This research will take advantage of tools developped by the applicant during his Marie Curie fellowship and will integrate tools and ressources developped by the host laboratory (Strand 3). This project identifies a collaboration with Prof. Malcolm Bennett (Centre for Plant Integrative Biology, Nottingham, UK) and builds upon the award of a long-term EMBO fellowship (ALTF 503-2010) to the applicant in Dr. Laurent Nussaume's laboratory (Laboratoire de Biologie du Développement des Plantes, CEA Cadarache, France). The outcome of this project will greatly improve our understanding of how plants perceive a low phosphate signal and how this signal is further transduced to generate an architectural response. Therefore, it will shed light on how plants adapt to a changing environment which may lead to application in crop improvement.

Keywords: plant development,root architecture,phosphate response,auxin response,arabidopsis
Should historical injustices be corrected? (HISTORICALINJUSTICES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2012-06-01
End date: 2016-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This research aims to examine whether historical injustices should be corrected. Historical injustices are cases of past wrongs, in which all the wrongdoers and all the victims have passed away. Are the descendants of the victims entitled to compensation? What kind of compensation? Who should bear the cost of this compensation, once all the wrongdoers have died? These are extremely difficult questions to answer, and they are politically sensitive. These are also practical questions, as courts in Europe, Australia and the U.S.A have struggled with those questions, and produced a variety of responses. A careful, balanced systematic and precise research project, in the discipline of political theory, on this topic is required, as while the importance of this topic is obvious, there are very few fully developed research projects on this topic. The research project will have two main parts. The first part is a full length book project on the question of historical injustices. The methodology of this book is that of analytical political theory. I intend however to examine several courts' decisions, including the important recent European human rights court decision of a case concerning Greek Cypriots. The second part, conducted in collaboration with scholars from UCLA and University of North Carolina at Chapel Hill, aims to examine some of the arguments, counter arguments and potential solutions in the context of the Israeli context. The final goal is to produce several peer reviewed publications on this topic, aside from the book mentioned.

Keywords: humanities,historical injustices,corrective justice,property rights,stability,supersession.
Estimation of neutral and adaptive/selective genetic variation in farm animal species (NEUTRADAPT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-06-01
End date: 2014-05-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Genetic variation can be differentiated, within the boundaries of current scientific knowledge, in functional variation and neutral variation. Functional variation includes adaptive and selective genetic variation: these are genetic mutations that play a role in the adaptation of farm animals to their environment (adaptive variation), or that have been under directional selection for traits of agricultural interest in farm animals (selective variation). Neutral variation is genetic variation that has no apparent influence on adaptation or on the traits under selection, and that is inherited along with adaptive and selective variation through linkage, genetic drift and other mechanisms. The estimation of the extent of neutral and non-neutral genomic regions in the genome of farm animals would be of great theoretical interest, contributing to unravel the mysteries of the genome with respect to coding and non-coding sequences, to regulatory regions and to functional and (apparently) meaningless mutations. Estimates of neutral and non-neutral genetic variation would also have great potential for applications in biodiversity studies and in genetic improvement of farm animals. This information would help identify animal breeds or populations at risk of extinction and in quantifying such risk. It would also be helpful in designing conservation programmes of genetic resources of endangered animal breeds or populations. From the perspective of genetic improvement of livestock, the knowledge of the neutral and adaptive/selective components of genetic variation could be used in focusing selection on such variation. In this way, therefore, neutral variation would not passively follow selection for goal traits due to linkage and genetic drift, but could be preserved contributing to the limitation of the rate of inbreeding and the conservation of genetic variability (lower Bulmer effect). More efficient selection schemes for farm animals could thus be designed.

Keywords: neutral and adaptive genetic variation,estimation of variation components,biodiversity,conservation of genetic resources,inbreeding rate,animal breeding,cattle,sheep,goats,whole genome data
Flow energy harvesting in assemblies of vibrating solids: stability analysis and non-linear coupled dynamics. (FLOWENERGY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-06-01
End date: 2014-05-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

The development of new energy harvesting technologies from renewable sources is essential for the European Union not only to prove its leadership in reducing greenhouse gas emissions, but also to achieve a greater energetic independence from limited fossil fuels. To assess the performance and identify the potential of particular technological designs to harvest energy from geophysical flows, a fundamental understanding of the underlying fluid-solid interactions instabilities and non-linear dynamics is essential. The proposed research project will adopt a fundamental point of view to investigate three aspects of flow energy harvesting using coupled fluid-solid instabilities: (i) the impact of the harvesting system on the fluid-solid dynamics, (ii) the coupling between multiple harvesting units through the flow and the coupled dynamics of lattices of vibrating solids, (iii) and the similarities with the active flapping problem as encountered in collective biological locomotion (e.g. fish schooling). Vibrating cylinders in cross flow and flexible plates in axial flows will be considered. This research work will be performed during Dr. Michelin's re-integration period at LadHyX at Ecole polytechnique after his research experience in the United States from 2005 to 2010. It will benefit from the scientific excellence of this institution and the expertise in these disciplines gained by Dr. Michelin during the beginning of his career. This project will ensure the long-term establishment of Dr. Michelin's research activities in Europe and the development of a leading research at Ecole polytechnique on flow energy harvesting.

Keywords: mechanical engineering,applied mathematics
Fungi in white biotechnology: Expression of novel lignocellulose degrading enzymes (FUNBIO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-03-01
End date: 2013-02-28
Duration (months): 24.0
Total project cost (EUR): 30000.0
EU funding (EUR): 30000.0
Participants: 1
Project status: CLOSED

White Biotechnology consists of modern applications for the sustainable processing and production of chemicals, materials and energy. It uses whole organisms and enzymes to synthesize products that are easily degradable, require less energy and create less waste during their production. Various agricultural, agro-industrial and forestry lignocellulosic residues are known to have a huge potential as cheap and renewable feedstocks for production of bioenergy and the opportunity of co-producing valuable-added chemicals. Lignocellulose represents the most abundant renewable organic resource. For the efficient decomposition of lignocellulose fungi utilise a set of hydrolytic and oxidative enzymes recognized as economically viable and environmentally friendly industrial biocatalysts. To make industrial applications feasible,an efficient production system for these enzymes would be needed. This project focuses on the science underlying the use of lignocellulosic materials in biotechnological applications. To further enhance our understanding of decomposition of lignocellulose by fungal enzymes, the project focus on the characterisation and heterologous production of new lignocellulose decomposing enzymes. These enzymes will be isolated, biochemically characterized and corresponding genes will be cloned and expressed in selected host organisms. Recombinant protein expression techniques in ascomycetes are not yet in use for the basidiomycete enzymes in the Univ. of Helsinki (UHel) thus setting-up these techniques will be of great importance. The combination of skills gained by the applicant during her MC Fellowship at the Univ of Nottingham and the excellent facilities at UHel make the project feasible and the project outputs will underpin the future career development of the applicant. The project will enhance continuation of collaboration between Nottingham and UHel in a research area which is competitive and has increasing need for collaborations and inter-disciplinarity.

Keywords: applied molecular biology,heterologous expression,lignocellulose degradation,basidiomycete,ascomycete,hemicellulase,esterase,laccase,heme peroxidase
Clustered Atomic Layer Deposition for Emerging micRoelectonic Applications (CALDERA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-03-01
End date: 2013-02-28
Duration (months): 24.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

A less-well known aspect of Moore's law is the need for increased drive current of the transistors. In addition to traditional dimensional scaling, recent work to improve the drive current is increasingly based on alternative materials with higher carrier mobility. When replacing silicon with III-V compound semiconductors as the channel material in CMOS devices, the main problem is the passivation of the interface between the channel and the gate dielectric due to defects created at the III-V surface by the formation of native oxides. It is important to either remove these defects or avoid their formation before the deposition of the gate dielectric to achieve acceptable electronic performance. The most promising gate dielectric for III-V materials is Al2O3 when grown by atomic layer deposition (ALD). Although ALD Al2O3 provides native-oxide-free interfaces with GaAs, the interface defect density is still much larger than on silicon and it is necessary to avoid the oxidation of the surface prior to gate dielectric deposition. Since GaAs has been reported as being deposited epitaxially by ALD, this will be a means to generate defect free surfaces. But to be effective, this must be combined with a clustered deposition of Al2O3 without any air break. The use of in-situ analysis tools in combination with a clustered deposition tool provide an ideal means to study the initial stages of ALD on III-V surfaces and the interface formation since all air exposure will be avoided. In-situ analysis during ALD has been done before, but never with a combination of analysis tools used on the same sample. Since no prior tools combining clustered ALD of both GaAs and Al2O3 and in-situ characterization techniques exist, a major part of the proposed work will be the design and the assembly of a clustered ALD deposition tool. By enabling such a combination, this project will provide the clearest insight into the growth mechanisms of ALD and of III-V interfaces to date.

Keywords: atomic layer deposition,high-k,iii-v devices,surface chemistry,reaction mechanisms ands dynamics,nanosystems,high vacuum technology,microengineering,materials engineering,cmos technology
Carbon-based nanoelectronics (CARBOTRON)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-05-01
End date: 2014-04-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Molecular electronics has the potential to go well below the size limitations of silicon-based electronics, such that the well known Moore's law can be maintained for much longer than with silicon alone. Without advances in nanoscale/molecular electronics, future computers would not be able to continue the current pace of development over the next twenty years. Molecular electronics can reduce the size of semiconductor rectifiers to the nanoscale by using single molecules as rectifiers. In addition, molecular electronics can also pave the way to single molecule sensing, which is an important part of the improvement of next-generation health care involving highly sensitive detection of toxic materials. Carbon-based nanomaterials such as carbon nanotubes, graphene, graphene nanoribbons, and carbonaceous molecular wires are the basis of carbon-based nanoelectronics. The 2009 edition of the International Technology Roadmap for Semiconductors (ITRS) recognizes the importance of carbon-based nanoelectronics, calling it an "emerging research information processing technology" and stating that it "exhibits high potential and is maturing rapidly". The study of carbon-based nanomaterials is important for the eventual realization of their vast application potential. The research in this proposal will focus on the theoretical multi-scale modeling of nanoscale carbon-based materials such as nanotubes and graphene, addressing multiple different topics. Nanoscale rectification will be studied by examining various single molecule rectifiers connecting graphene or nanotube electrodes. Single molecule sensing will be studied by looking at functionalized graphene. The electronic structure of small diameter carbon nanotubes and small molecules that are of interest in molecular electronics will be examined with state-of-the-art methods that go beyond conventional density functional theory and can provide reliable predictions for experimentalists.

Keywords: condensed matter properties,molecular electronics
A NOVEL NON-INTEGRATING REPLICATION LIMITED LENTIVIRAL-BASED VECTOR FOR HIV VACCINATION (HIVNONILV)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-07-01
End date: 2014-06-30
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Innovative vectors and strategies are hardly needed to generate safe and efficacious HIV vaccines. Many types of recombinant viruses and DNA vectors have been used to induce protective immunity in the macaque model of HIV vaccine. However, the extent of protection achieved by these vaccines remains disappointing compared to Live-attenuated vaccines. We focused in development of lentiviral-based vectors as DNA vaccines and have shown that our first generation vector was efficient alone to induce protection of monkeys from AIDS following challenge with highly pathogenic homologous virus. We recently characterized the immune responses associated with this protection in immunized macaques. In this project we developed novel lentiviral vectors (lentivector) that have never been tested before. These lentivectors are non-integrating (NONI-LV) into the host genome and are driven by LTRs that have constitutive promoters. These innovative vectors synergize the properties, without the inconvenient, of both DNA and Live-attenuated vaccines. We hypothesize that these vectors will induce responses strong enough to induce protection against heterologous challenge viruses. Our long term goal is to develop safe and efficacious prophylactic vaccines against HIV in humans. The goal of the present project is to evaluate the immunogenicity and the safety of our novel NONI-LV vectors and the protection against pathogenic viruses in the non-human primate model of HIV. The work plan includes 4 major specific aims. In aim 1, we will focus on the safety of this type of vector by demonstrating their inability to integrate into the host genome. In aim 2 we will explore the immunogenicity of this vaccine vector in humanized SCID/NOD mice compared to our first generation vector. In aim 3 we will explore the immune responses induced in monkeys. In aim 4 we will explore the efficacy of induced immune responses to protect immunized monkeys against heterologous pathogenic viruses.

Keywords: health sciences,hiv,aids,vaccine,vector,caev,lentivirus