Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Functional analysis of TSPAN14 as a genetic risk factor for Alzheimer’s disease (TSPAN14-AD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: CLOSED

Alzheimer’s disease (AD) is the most prevalent deadly neurodegenerative disorder for which no effective treatment exists as of today. Therefore, there is an urgent need to better understand the molecular mechanisms behind AD in order to develop more effective treatments against this complex disease. Recent genetic findings have highlighted several AD-associated genes, many of which are preferentially expressed in microglia in the brain. One of these is tetraspanin 14 (TSPAN14), whose physiological function in the brain is not yet understood. Recent studies suggest that TSPAN14 may act as a functional regulator of ADAM10, a transmembrane protease that cleaves multiple substrates in the brain including the AD-associated protein TREM2. Full-length TREM2 is essential for the phagocytic activity of microglia and its cleavage by ADAM10 results in loss of function. The central aim of the TSPAN14-AD project is to understand how TSPAN14 controls molecular pathways involved in AD, by focusing on proteolysis and function of TREM2. Specifically, we hypothesize that TSPAN14 increases AD risk by modulation of TREM2 cleavage and microglial phagocytosis. The 3 objectives of TSPAN14-AD are to: (1) determine whether AD-protective TSPAN14 alternative splicing variants result in reduced TSPAN14 protein expression; (2) elucidate whether reduced TSPAN14 expression results in decreased ADAM10 cell surface expression; (3) assess whether loss of TSPAN14 reduces TREM2 cleavage and enhances phagocytic activity of microglia. To accomplish this, a combination of biochemical, molecular, and proteomic techniques will be used within both in vitro and in vivo models, including human induced pluripotent stem cell (iPSC)-derived microglia and post-mortem human brain tissue. Outcomes of the project have the potential to fill in a large gap in our current understanding of molecular mechanisms leading to AD pathogenesis and may provide insight into novel therapeutic targets for AD and related disorders.

Keywords: alzheimer s disease,induced pluripotent stem cells,microglia,tspan14,trem2,adam10 alpha secretase,neurodegeneration
Femtosecond laser processing for micro- and nanopatterning of metal halide perovskite thin films for enhanced light management in solar cells (SPARKLES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Belgium,Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 2
Project status: SIGNED

Photovoltaic technology stands as a beacon in the challenge to reduce CO2 emissions by maximizing the use of solar energy. Over the past decade, perovskite materials have emerged as game-changers, offering a powerful combination of affordability and high efficiency. In addition, their remarkable properties make them prime candidates for solar cell applications and are called to revolutionize photovoltaic technology. However, there is still room for improvement in enhancing their light management capabilities. Numerical simulations in perovskites have shown the potential of nanopatterning for the enhancement of light management, but the current landscape of nano- and micropatterning techniques is often time-consuming and unsuitable for large-scale industrial applications. This bottleneck hampers the realization of the full potential of perovskite solar cells. SPARKLES is a pioneering project aimed at revolutionizing perovskite technology. The main objective is to develop an innovative approach that enables rapid, large-area patterning of perovskite thin film surface in a single and efficient step for enhancing light management. This is possible thanks to femtosecond laser processing, a cutting-edge technology that creates Laser-Induced Periodic Surface Structures (LIPSS). This finely tunable periodic line-pattern promises to optimize the light management capabilities of perovskite solar cell devices. LIPSS are the result of an interference phenomenon which allows patterning large areas in the blink of an eye, making them a perfect fit for industrial-scale production. The novel strategy proposed in SPARKLES achieves mask-less patterning without the need for harmful chemicals, ensuring a clean and sustainable process. SPARKLES is poised to illuminate the future of perovskite-based solar energy, making stride towards a greener and more efficient tomorrow.

Keywords: perovskite,fs laser processing,lipss,light management,mass production
Search for physics beyond the standard model with highly charged ions (AlphaVar)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 2499833.0
EU funding (EUR): 2499833.0
Participants: 1
Project status: SIGNED

Spectroscopy has been a central tool in modern physics: it has helped us understand atomic structure, the expansion of the universe and the composition of exoplanet atmospheres. Today, high-precision spectroscopy is one of the most promising tools for investigating some of the most fundamental open questions: many theories beyond the standard model of particle physics can be tested by detecting tiny changes in atomic transition frequencies caused by the interaction with new particles, new forces or the variation of fundamental constants. An especially attractive target is the search for temporal or spatial variations of the fine-structure constant, which is predicted by several different theories. Highly-charged ions (HCIs) are especially well suited for this search, as they have transitions that are over an order of magnitude more sensitive to the fine structure constant than most other atomic systems. The precision necessary for these measurements will soon be within reach, thanks to recent demonstrations of sympathetic cooling and quantum-logic spectroscopy of HCIs. I propose an experiment that simultaneously probes two of the most sensitive transitions in HCIs using quantum logic spectroscopy and directly compares their transition frequencies. This method doubles the advantage of their enhanced sensitivities and reduces systematic effects introduced by an indirect comparison via the SI second standard. Together, these gains will allow an improvement of over two orders of magnitude on current bounds on the temporal variation of the fine-structure constant. I will also take advantage of the exotic nature of these extreme atoms to test further theories of fundamental physics. In particular, I plan to exploit their enhanced Rutherford scattering cross section to determine an improved limit on the number density of proposed millicharged dark matter particles. This data will help narrow down the most viable theories for physics beyond the standard model.

Keywords: precision measurements,tests of fundamental physics,highly charged ions,quantum logic spectroscopy
Group Formation under Conflict: An Experimental and Theoretical Study of Causes and Consequences (GROUPFORM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

Theoretical and experimental research has significantly advanced our understanding of the economic and psychological factors underpinning human group conflict. Yet, a critical gap persists: nearly all existing research assumes that competing groups are fixed. This neglects the fact that conflict actively and dynamically affects group formation and that this can have a crucial impact on competitive success. Here, I propose to examine key drivers and consequences of such group formation processes under conditions of conflict. Specifically, I contribute to answering three related research questions: (i) How do people choose which groups to join under conditions of conflict? (ii) How do group size and social identity interact to influence these choices? And (iii): How do such group formation processes impact groups’ competitiveness and success? I tackle these questions via two independent yet complementary work packages (‘WPs’): WP1 combines game-theoretic analyses with a series of experiments to systematically examine how key group characteristics impact group choice under conditions of conflict. Specifically, it tests for the influence of structural aspects such as group size and psychological factors tied to social identity. WP2 uses agent-based simulations to investigate how individuals' preferences for group choice evolve over time in response to the adoption of group-level strategies aimed at resolving collective action problems. Part 1 will assess how variations in the type and effectiveness of these strategies affect group choice, size, and success. Part 2 provides a theoretical analysis of the role of social identity in group formation, complementing WP1’s empirical findings. This project advances a novel line of inquiry into the precursors and mechanisms underlying intergroup conflict, contributing significant insights into how structural and psychological factors drive group formation in this context.

Keywords: group formation,alliance formation,group conflict,social identity,intergroup relationships
Entanglement-based Quantum Key Distribution Networks (eQKD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Austria
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Quantum Industries GmbH (“QI”) is pioneering the global cryptography market with its entanglement-based quantum communication technology. Founded in April 2023, the company aims to utilize its 40+ years of combined world-class know-how in quantum key distribution (“QKD”) to become a European unicorn within seven years. QKD is critical for securing telecommunications against quantum computing security threats, with applications across various industries and potential for high sales growth. QI’s unique entanglement-based Quantum Key Distribution (eQKD) systems enable fully connected communication network topologies with linear resource scaling, a significant advancement over the competition’s point-to-point QKD systems. The USPs of QI’s eQKD solution, besides scalability, are its high data rates (100 Mbit/s), and long communication distances (350 km). QI’s sales strategy rests on two pillars: establishing a key-as-a-service business model and selling systems and networks directly to customers who need to own the systems for security reasons. Target countries for QI’s products include NATO member states, with a prime focus on Europe, and industries such as telecommunication, financial services, public transport, government, military and overall critical infrastructure. The company's innovation in eQKD technology is based on scientific achievements by its team, including the "best source of entanglement ever" and the first international fiber connection carrying entanglement over international borders, proving TRL 6. These achievements have demonstrated the potential of QI’s fiber-based eQKD solutions to bring its unique quantum networking technology to TRL 8 with the help of the EIC Accelerator. Quantum Industries' eQKD systems are the only technology that allows for 100% safe and future-proof communication in networks, providing a truly future-proof way to face the quantum computing security threat.

Keywords: high speed and long distance quantum key distribution,fiber based quantum communication using entanglement,unhackable future proof telecommunication,quantum computer interconnections
European Glocal Counter-Terrorism (EU-GLOCTER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland,Germany,Poland,Australia,United Kingdom,United States,Indonesia,Spain,Czechia,Brazil,Belgium,Israel,Netherlands
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 2597803.2
EU funding (EUR): 2597803.2
Participants: 26
Project status: SIGNED

Terrorism remains one of the main security threats facing the European Union (EU) and its Member States, with a considerable impact on European societies. There is therefore a strong need for knowledge and expertise that will enable the EU and its Member States to effectively address the contemporary terrorist threat. The EU-GLOCTER (EUropean GLOCal Counter-TERrorism) Doctoral Network will produce the expertise that the EU and its Member States require to effectively address this threat. The research programme is highly innovative in its emphasis on analysing EU counter-terrorism through the lenses of ‘glocalism’ at different levels, ranging from the local through the EU to the global level, and in the crossing of the public-private sector boundaries. EU-GLOCTER brings several beneficiaries with an excellent research track-record in counter-terrorism together with a range of Associated Partners from across the world in order to deliver a world-class PhD programme. The EU-GLOCTER project will train 11 doctoral candidates (DCs) using cutting-edge resources at leading research facilities, universities and think thanks throughout the EU and globally in the most important centres of power. The research programme involves world-leading social scientists (from a range of disciplines including political science, criminology, sociology, policing, and law) in combination with innovative think thanks and industry partners. The two main objectives of EU-GLOCTER are: (1) to provide world-class training to DCs in EU ‘glocal’ counter-terrorism - thinking globally, responding locally; and (2) to generate scientific excellence and technological innovation in the area of counter-terrorism.

Keywords: european union counter terrorism european security international security terrorism and political violence glocalism
Theranostic magnetic nano-based codelivery system for boosting cancer immunotherapy (MultiTheranostic)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal,Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 172618.56
EU funding (EUR): 172618.56
Participants: 2
Project status: SIGNED

Cancer is a leading cause of death and a major impediment to increasing life expectancy around the globe. Amongst all skin cancers, melanoma is a hard-to-treat disease, owing to its high potential for metastasis, and it remains as one of the most aggressive cancers. Single therapy is not efficient to tackle metastatic melanoma and a combination of therapies is thus emerging as a necessity to efficiently eradicate all cancer cells. Recently, immunotherapy, in particular immune checkpoint inhibitors (ICI), has become a powerful treatment strategy for cancer. Nevertheless, the physical barriers represented by cellular and non-cellular components of the tumour microenvironment combined with immune escape mechanisms of cancer, hamper an efficient tumour infiltration and patients’ responsiveness to ICI therapy. In this context, MultiTheranostic aims to develop theranostic nanoparticles for gene therapy-mediated immune checkpoint silencing and chemotherapy, exploiting the properties of magnetic nanoparticles to induce damage locally on the tumour microenvironment by magnetic hyperthermia (MH). This multimodal theranostic approach, incorporating MRI tracking, is versatile, as it could be also applied to other types of solid tumours. MultiTheranostic objectives are (i) to synthetize and validate a biocompatible magnetic lipid nanoparticle (NPs) incorporating silencing RNA against ICI targets, and chemotherapy (WP1, WP2), (ii) to develop a tissue-engineered (TE) model for screening and monitoring the efficacy of the NPs (WP3), and (ii) to demonstrate the effectiveness of the final drug delivery system as a multimodal theranostic approach for metastatic melanoma (WP4). With MultiTheranostic the researcher will greatly expand her scientific expertise in the fields of nanotechnology and bioengineering, positioning her as a leading independent researcher, contributing to the advancement of nanomedicine in Europe and beyond.

Keywords: theranostics magnetic nanoparticles chemotherapy gene silencing magnetic hyperthermia combinatorial treatment mri tissue engineered models metastatic melanoma gene based immunotherapy
Health Innovation Next Generation Payment & Pricing Models (HI-PRIX)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Maintaining an innovative, sustainable and globally competitive health industry
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Austria,Spain,Belgium,United Kingdom,Lithuania,Portugal,Netherlands,France
Call: New pricing and payment models for cost-effective and affordable health innovations (HORIZON-HLTH-2022-IND-13, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 3962457.5
EU funding (EUR): 3962457.5
Participants: 18
Project status: SIGNED

The variety of innovative technologies with the potential to revolutionize the delivery of health care means that the policy toolbox will need several pricing and payment models, adapted in their design and implementation according to the specific situation. Although there are examples of novel pricing and payment models, the lack of appropriate data infrastructure, legal barriers and unwillingness to adapt current systems often prevent their use. Therefore, the overall objectives of the Health Innovation Next Generation Pricing Models (HI – PRIX) project are: i) to map and formulate new pricing and payment schemes that can be used across technology classes, therapeutic areas, setting and healthcare systems/geographies together with a related set of principles that may guide successful adjustment and flexible implementation to the context of use; ii) to investigate the impact on competitiveness, innovation, equity and affordability of a pipeline of contracting modalities for health innovations; iii) to address the challenges and concerns of payers, manufacturers, healthcare professionals, and patients about different models of pricing by sustaining an effective dialogue across stakeholders’ groups about the trade-offs between affordability, innovation and patient access. Coordinated by Bocconi University, the HI-PRIX Consortium involves 18 partners from 10 European countries, including academic institutions, public authorities, healthcare providers, and independent research organizations. Through theoretical models, quantitative simulation, qualitative research work and case-studies, this three-year project structured around 10 WPs, will generate new evidence on the role of public sector in R&D and indirect medical and environmental costs in pricing and reimbursement determinations, on the pricing dynamics over pharmaceutical products’ lifecycle, on the impact of policies and incentives on the competitiveness, innovativeness and equity in the healthcare system.

Keywords: pricing models payment schemes innovation affordable healthcare system competitive life science industry
Cell line engineering for imporved fertility treatment (Kyron.bio WomenTech)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: France
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-01-31
Duration (months): 7.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

kyron.bio is a female led biotech company on a mission is to unclog bottlenecks in therapeutic protein production, allowing better drugs to reach patients. We are using synthetic biology to engineer mammalian cell lines for improved bioproduction, harnessing highly efficient enzymes from diverse life forms. Our preliminary data demonstrates a 3X yield gain for the amount of therapeutic produced in our system, with further gains in yield, activity and stability predicted post optimisation

Keywords: cell line engineering,therapeutic production