Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
In search of PERFECTION – the phenomenon of unnatural amino acids in chemical biology for biological and medical applications (PERFECTION)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Panel: Chemistry
Countries involved: Poland
Call: ERA Chairs (HORIZON-WIDERA-2023-TALENTS-01, 2023)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

PERFECTION foresees launching the Department of Chemical Biology for Biological & Medical Applications (DCB) at the Institute of Physical Chemistry PAS (IChF) by Prof Marcin Drąg (ERA Chair holder, ECh), an excellent biological chemist with expertise in combinatorial chemistry of proteolytic enzymes and their applications. IChF is renowned for its methods of measuring and analysing physical, chemical and biological systems. Yet, we lack biologically relevant molecules to improve these methods and tackle complex health issues. We also need more recognition from partners to join project consortia and better exploit our research results. Under the project, DCB will undertake close collaboration with IChF’s researchers, supplying them with novel compounds (modified peptides with unnatural amino acids, UAA) for broad-ranging studies on new chemical markers to target diverse diseases. DCB will also offer leading structures to support the creation of UAA-based drugs, similar to those in Nirmatrelvir/Paxlovid (a SARS-CoV-2 drug that uses UAA discovered by Prof Drąg and team; Nature Chem Biol, 2021). The project measures involve revamping the IChF Research Agenda, training, guidance, and mentorship of IChF researchers by ECh, coupled with enhanced networking with academic and industry partners. We will also tackle the shortage of international researchers available for IChF by setting up training research programmes on drug/diagnostics delivery. To further solidify our partnerships with stakeholders, we will refine IChF’s research management practices, notably in IP management and stakeholder communication. Our efforts will be bolstered by support from 14 research institutions and 6 companies (i.a., Stanford University School of Medicine, Genentech, Kintsugi) that have committed to the project. The ultimate project goal is to establish IChF as a premier research entity recognised for cutting-edge chemical tools for biological chemistry applications and their market launch.

Keywords: chemical biology,unnatural amino acids,peptides,inhibitors of proteases
Protecting modern open-source web applications (PROWEB)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Estonia
Call: Strategic Digital and Health Technologies (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-06-01
End date: 2024-11-30
Duration (months): 30.0
Total project cost (EUR): 2720080.0
EU funding (EUR): 1904000.0
Participants: 1
Project status: CLOSED

The modern way of creating websites relies on using open-source code and plugins that are used as “pre-existing building blocks”. This has made building websites much faster and cheaper. It is the reason why this approach is now being used for creating everything from small personal blogs to large media outlets and web pages of Fortune 500 companies. However, using open-source code introduces a major risk as the security of the website can be compromised. With parts of code originating from a wide variety of different sources, it is very complicated to check all this content and make sure the sites cannot be penetrated by hackers. To solve this problem, we have created a novel solution that combines the independent security researchers’ with our automated virtual patching technology. This way we know about the security vulnerabilities first and can provide the most effective protection against open-source code vulnerabilities. Thus making the web safer for everybody.

Keywords: content management systems,plug ins,third party code,open source community,open source,website protection,wordpress
SUPRAMOLECULAR AGENTS AS RADIOTHERANOSTIC DRUGS (SMARTdrugs)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Netherlands,Spain,Switzerland,United Kingdom,Portugal
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 2713190.75
EU funding (EUR): 2713190.75
Participants: 6
Project status: SIGNED

From diagnostic applications in the quantification and characterisation of biomarker expression in cancer patients, through to molecularly targeted radionuclide therapy, radiopharmaceuticals are at the frontline of modern personalised medicine. The radical long-term vision of SMARTdrugs is to harness the untapped potential of supramolecular chemistry to create a new class of therapies - radiotheranostics - which combine both diagnostic and therapeutic radionuclides in one compound. By using the self-assembly of host-guest supramolecular coordination complexes and molecularly interlocked molecules as scaffolds for creating supramolecular radiotheranostic drugs, new methods for radiotheranostic synthesis that break away from conventional medicinal chemistry concept will be introduced. SMARTdrugs will establish a proof-of-concept demonstrating the utility of non-covalent systems in the design of multifunctional radiotheranostic agents with tailored pharmacokinetics, and their application in challenging drug-delivery scenarios including targeted delivery to cancers of the lung and brain. Our 3 main objectives: Objective 1 – Develop new chemical landscapes using non-covalent bonding to create functionalised supramolecular compounds for cancer-specific theranostics Objective 2 – Elucidate the key relationships between supramolecular radiotheranostics and the complex tumour microenvironment that determine drug efficacy in vivo Objective 3 – Perform head-to-head studies to establish a proof-of-principle that supramolecular chemistry is a viable alternative to classical radiopharmaceutical design The long-term goal is to establish a new chemical landscape for radiotheranostic design, and to facilitate clinical translation of this new technology. Successful experiments will lay the foundations for exploiting supramolecular chemistry in the wider context of drug delivery and theranostics, and for studying biological interactions at the cellular to whole-organism levels.

Keywords: supramolecules,theranostics,imaging,therapy,cancer,blood brain barrier
MIGRALIGHT: effects of urbanisation and artificial light at night on the migration of a nocturnal bird (MIGRALIGHT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Switzerland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2027-07-31
Duration (months): 36.0
Total project cost (EUR): 317205.6
EU funding (EUR): 317205.6
Participants: 2
Project status: SIGNED

The itinerant lifestyle of migratory species makes them especially vulnerable to changes in environmental conditions. Understanding how migratory species respond to human-induced changes in the environment is nowadays of paramount importance to conserve migratory species and the diversity of migratory behaviours. In particular, urbanisation and artificial light at night (ALAN) could have important impacts on migratory species. Urbanisation changes environmental harshness, potentially offering new wintering areas with milder temperatures and higher food availability for migratory species. ALAN modifies the airspace over which individuals migrate, potentially fragmenting the sky and generating barriers for airborne migratory animals. Understanding how these two anthropogenic factors affect migration and its population consequences are now essential to anticipate the response of migratory species to anthropogenic global change. Combining expertise from the Swiss Ornithological Institute (Switzerland) and Doñana Biological Station (Spain), this interdisciplinary project will investigate how urbanisation and ALAN affect long-distance bird migration and the evolutionary implications of such effects. Specifically, this project will (i) identify differences in migratory behaviour between urban and non-urban bird populations; (ii) test the effects of ALAN on migratory behaviour across a broad geographical range; and, (iii) determine the genetic population structure and connectivity of migratory populations exposed to varying levels of anthropogenic environmental pressure. To address these questions, this project will use a long-distance migratory owl, the Scops owl (Otus scops), an ideal species to achieve the aims of this project. The findings of this project have the potential to inform conservation plans for migratory species and the management of ALAN in cities.

Keywords: bird migration,urban ecology,urbanisation,alan,artificial light at night,ornithology
Echoes of Experience: How statistical and reward learning guide our decisions (RewSL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

Our visual system constantly encounters a plethora of stimuli, drastically surpassing our processing capabilities for in-depth analysis. It is hence essential to select the element(s) that is most relevant for our objectives and ignore irrelevant ones. One helpful feature for this is that the world is characterized by numerous regularities making it partially predictable. Our brain can extract these regularities from past experience and use them to efficiently guide target selection. Recently, significant scientific interest has been directed to two forms of learning that focus on two types of regularities: in reward-mediated learning (RL), people learn which stimuli are associated with reward, prioritizing the elements related with high (vs. low) reinforcement. Statistical learning (SL), in contrast, allows people to extract statistical regularities from the environment, such as how often a stimulus occurs in a specific location, optimizing future actions toward the location where the relevant element appears frequently. In everyday life RL and SL coexist and they jointly guide our selection of relevant stimuli. However, they have been mainly addressed separately using divergent tasks, hindering a direct comparison of the results and assessing their combined influence. This project seeks to bridge this gap by systematically comparing RL and SL in a systematic and well-balanced experimental setup to understand how people implicitly learn from their past experience. Using a series of consistent experimental tasks, behavioral, ocular and electroencephalography measures will be recorded from healthy human volunteers to assess the individual and joint effect of RL and SL on the process dynamics from target selection until response execution. Furthermore, employing Markov decision process models, we will compare the observed performance with model performance. Jointly, our results will provide important insights into real-world learning mechanisms.

Keywords: reward mediated learning,statistical learning,eeg,computational model visual selective attention
Securing Holistic and Impactful Food Systems Transformation with Novel Foods based on alternative proteins (EPIC-SHIFT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Sweden,United Kingdom,Finland,Denmark,Spain,Greece,Italy,Belgium,Poland,Netherlands,France,Germany,Australia,Japan
Call: Impact of the development of novel foods based on alternative sources of proteins (HORIZON-CL6-2024-FARM2FORK-01, 2024)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 4499427.5
EU funding (EUR): 4499427.5
Participants: 20
Project status: SIGNED

The current food system is unsustainable and underperforming, having high environmental and socio-economic costs, while still failing to ensure food and nutrition equity for all. Dietary shifts towards novel foods based on alternative protein sources (NFAP; proteins derived from insect, fungi, bacteria, micro and macro algae and agriculture and aquaculture by-products), provide a unique opportunity to reduce consumption of animal-based proteins potentially minimizing the impact of the Food Systems. However, knowledge regarding the environmental, economic and social impact of the widespread production, provision and consumption of NFAP is very limited and not integrated into a holistic vision of the food system able to identify trade-offs, interaction between food system actors and second and third order impacts. The goal of EPIC-SHIFT is to provide an unprecedented, independent, solid knowledge base on the sustainability (env., eco. and soc.) aspects of NFAP as options for protein diversification for human consumption. Considering that the contribution of each NFAP types to reorganize the food systems may differ, EPIC-SHIFT applies a quadruple helix innovation model in its multi-actor approach to roadmap the sustainable development of NFAP for Planetary Health Diets. Designed as a think-tank and adopting Food Systems Thinking approach, EPIC-SHIFT will provide a multidimensional impact assessment of 7 NFAP (from protein type to product level) at scale complemented with the necessary recommendations for food environments, marketing, regulatory approval, infrastructure and investment needed to support long-term market growth. EPIC-SHIFT integrated scenario analysis will further result in decision support tools that will inform policy and decision-making about the trajectories to achieve the sustainable integration of NFAP in the EU diets ensuring resource efficiency, food security and nutrition within a framework of just transition for all food system actors.

Keywords: novel foods based on alternative protein sources,food systems thinking,multi actor approach,lca,tea,s lca,just transition,nutrition and health impacts,true cost of food,market potential
Cognitive Decentralised Edge Cloud Orchestration (CODECO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Greece,Luxembourg,Netherlands,Israel,Switzerland,Sweden,Ireland,Portugal
Call: Cognitive Cloud: AI-enabled computing continuum from Cloud to Edge (RIA) (HORIZON-CL4-2022-DATA-01, 2022)
Start date: 2023-01-01
End date: 2026-03-31
Duration (months): 39.0
Total project cost (EUR): 6060537.5
EU funding (EUR): 6060537.5
Participants: 22
Project status: SIGNED

CODECO is a cognitive, cross-layer and highly adaptive Edge-Cloud management framework with a unique orchestration approach that provides support for data management and governance decentralised data workflow; dynamic offloading of computation and computation status; and adaptive networking services (TRL5). In the core of the CODECO framework are privacy preserving decentralised learning mechanisms to i) reduce latency and power consumption from the far Edge to Cloud; ii) adjust the computation in real-time to available Edge-Cloud constraints; iii) adjust running services into the needs of the application, the data sources, the surrounding context; iv) benefit from a flexible networking infrastructure that adapts to the needs of active services; and v) democratize the technology to a faster market adoption of the toolkit, as well as products and services derived from it. CODECO proposes the following assets: i) A1: Open, cognitive toolkits and smart Apps, integrating the elastic and advanced concepts to manage, in a smart and flexible way, containerized applications across Edge and Cloud (dynamic cluster and multi-cluster environment; ii) A2: A developer-oriented open-source software repository, to be available in an early stage of the project, thus allowing for early exploitation of initial, advanced results and a better adaptation throughout the project lifetime; iii) A3: Training tools, to support the development of services based on the CODECO framework; iv) A4: Use-cases across 4 domains (Smart Cities, Energy, Manufacturing, Smar Buildings), as the basis for experimentation and demonstrations; v) A5: a Research and Innovation community engagement programme, based on the different use-cases and including the different CODECO stakeholders; vi) A6: CODECO integration into the large-scale EdgeNet , experimental infrastructure, to assist in the building of experimentation and novel concepts by the research community.
Engineered viscoelasticity in regenerative microenvironments (devise)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Spain
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2497246.0
EU funding (EUR): 2497246.0
Participants: 1
Project status: SIGNED

Tissues are viscoelastic materials whose mechanical properties evolve with time and yet this important property has not been incorporated in the design of regenerative biomaterials. Mechanical properties of biomaterials are known to influence fundamental cellular process, including cell migration, cell growth and cell differentiation. However, most of the work to understand the mechanical properties of substrates on mesenchymal stem cell (MSC) differentiation has made use of pure elastic materials. Cells probe their environment by pulling forces and receiving mechanical feedback through membrane receptors. Since viscoelastic materials respond with a time dependent process to force, we hypothesise that viscoelasticity will play a fundamental role in the differentiation of mesenchymal stem cells and hence in the design of regenerative biomaterials. This project will develop (a) a new family of viscoelastic hydrogels with controlled properties that include biochemical functionalities (recapitulating the properties of the extracellular matrix in vivo), extreme mechanical properties (i.e. very low/high elastic and viscous properties) and mechanical gradients; and (b) Brillouin microscopy to follow the evolution of the local viscoelastic properties of these cell-laden materials as a function of time. we will use viscoelastic materials to promote bone regeneration in vivo using our critical-sized defect in the mouse radius model and, in a major attempt to move the field forward, we will further develop Brillouin microscopy to monitor the viscoelastic properties of regenerative microenvironments in vivo.

Keywords: viscoelastic materials,mesenchymal stem cells,tissue engineering,brillouin microscopy
Additional financial support to project TRAMPAS (TRAMPAS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: MSCA other
Action type: Coordination and support actions
Countries involved: United Kingdom
Call: HORIZON-MSCA-SNLS-2021-IBA (HORIZON-MSCA-2021-SNLS-IBA, 2021)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 48062.5
EU funding (EUR): 48062.5
Participants: 1
Project status: CLOSED

Request of financial support to cover the additional costs that researchers/staff members with disabilities face due to the increased costs of their mobility and/or to ensure necessary assistance by third persons or for adapting their work environment.

Keywords: temporomandibular disorder,trigeminal nerve injuries,long term physical illness,hyperacusis,soil science related illnesses,