Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Foods for diabetes and cognition (FODIAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Spain,Italy,Italy,Spain,Spain,Sweden,United Kingdom,Portugal,Portugal,Portugal,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-04-01
End date: 2023-03-31
Duration (months): 60.0
Total project cost (EUR): 432000.0
EU funding (EUR): 432000.0
Participants: 15
Project status: SIGNED

FODIAC aims to develop a dietary solution to tackle type 2 diabetes and cognitive dysfunction of the elderly. FODIAC will enhance the quality of R&I in Europe, promoting cooperation along the Food Value Chain. This is achieved through advanced international, intersectoral, cooperation between 7 academic and 8 industry partners. For this purpose, FODIAC assembles a European multi/interdisciplinary consortium, composed of partners in 5 countries that provide expertise in: extraction and purification of bioactive molecules, nanotechnology, nano/micro-encapsulation, toxicology, nutrition, biomarkers, clinical trial management. Rationale: lack of knowledge sharing among academia and industry acts as a barrier for the development of functional foods for the elderly, who represent one of the fastest-growing population segments worldwide. Approach and Outcomes: FODIAC coordinates the actions of individual partners, academic and industrial, using Exchange of Staff as a tool to capitalize on complementary competences to: i) conduct joint research; ii) protect the Intellectual Property based on this research; iii) foster the transference of the generated knowledge, skills, and technology to the industrial sector; and iv) exploit research output to the benefit of society. FODIAC’s outcomes will include: i) an increase in the R&I capacity among participating partners; ii) boosting of knowledge transfer of emerging micro/nano-biotechnologies from academia to industry, to develop cost-effective processes; iii) commercialization of new functional ingredients and functional foods containing antidiabetic and cognitive-enhancing bioactive molecules; iv) acceleration of the development of dietary recommendations and interventions based on those products, to improve the quality of life of the elderly; iv) a sustainable research network of academic and industrial partners and v) the leveraging of career perspectives of individual researchers, both in and outside academic institution

Keywords: polyphenols,anti diabetic,cognitive disfunction,functional foods,encapsulation,bioactivity
Chemically synthesised novel compounds for the stabilisation of biologics (ExtremoChem)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Portugal
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Biologics are medical drugs produced using biotechnology, other than direct extraction from a native biological source. Many of biopharmaceutical products are subject to very strict production, storage and distribution requirements in order to preserve effectiveness and safety. Biopharmaceuticals stability is a key issue in assuring that these medicines maintain their quality, safety and full potency. Once potency is lost, it cannot be restored, this means the biologic is wasted. ExtremoChem synthesises a line of novel compounds consisting of synthetic small organic molecules, from 8 to 12 carbons, that are able to stabilise proteins and other biological material by preventing their degradation under stressful conditions, such as higher or lower temperatures, pH, salinity, agitation under which they would otherwise degrade. eXtremochem is suitable for a wide range of proteins such as mAbs, vaccines, insulins, interferins and etc. But ExtremoChem currently focuses on mAbs, such as Humira (for rheumatoid arthritis) & Neupogen (for growth of white blood cells), since they present a high value market. The eXtremochem compounds improve the stability of molecules in the most critical purification stages and protects biologics, preventing aggregation and increasing production volume by 20%. Furthermore, eXtremochem enables long-term storage of thermally sensitive biologics without the need for cold chain, thus bringing significant savings to biopharmaceuticals – 6.5% of their revenues. The Phase 1 project will allow ExtremoChem to evaluate the medicines’ degradation under the presence of the small organic molecules through several stabilization tests, prepare a feasible industrial scale-up plan, plan a sound Ph 1 clinical trial, elaborate the business scale up, and size the reachable market and a reliable market share. Within the overall project, ExtremoChem aims to: obtain the clinical validation and sign at least one commercial agreement.

Keywords: biologics,biopharmaceuticals,protein stabilisers,synthetic molecules,monoclonal antibodies
The Psychology of Administrative Burden (POAB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2024-01-31
Duration (months): 60.0
Total project cost (EUR): 1499611.0
EU funding (EUR): 1499611.0
Participants: 1
Project status: SIGNED

The burdens of dealing with administrative rules and red tape in government are a fact of life around the world, ranging from small hassles to heavy burdens in the form of stigmatizing processes of proving eligibility and facing potential sanctions. In light of the immense importance of such burdens for millions of people and for the effectiveness of benefit programs, we know surprisingly little about the conditions that give rise to experiences of burden. POAB combines and extends extant theory and uses a unique combination of experimental methods and data to explain how, why, and for whom administrative rules are experienced as burdensome. POAB studies comprehensive rules regarding unemployment and social benefits and will provide novel register, physiological, and survey measures of welfare benefit recipients’ experiences of burden. I develop and test three theories to explain differences in experiences of burden: 1) How resource scarcity causes cognitive load and hence reduces the ability to cope with rules; 2) How self-efficacy increases the ability to cope with rules; and 3) How perceptions of being undeserving cause stigma and stress. POAB analyses the causal impact of rules on burden. To this end, I use a unique combination of complementary experimental methods in political science: 1) Cross-national lab experiments with physiological measurement and manipulations of rules, scarcity, efficacy and deservingness perceptions; 2) Cross-national survey experiments to assess different aspects of rules in different contexts; 3) Quasi- and field experiments to assess the impact of rules on register measures of burdens in a real-world context. POAB offers a fundamentally new interdisciplinary approach by bridging the gap between research on administrative burdens and psychological perspectives. The project’s output will provide profound knowledge of citizens’ experiences of burden and the inequalities in such experiences among recipients of major welfare benefits.

Keywords: administrative burden,welfare benefits,inequality,resource scarcity,deservingness,self efficacy,experimental methods,cognitive science
A solar based, internally-illuminated bioreactor for microalgae cultivation (Brevel)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-04-01
End date: 2018-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Microalgae can be of great benefit as a food source, as a natural source for a wide range of products and as biomass for production of biofuels as they can replace synthetic and/or fossil biomass, but they are far from reaching their commercial potential, because their cultivation is expensive and inefficient, limiting their use to high-value markets. An important product derived from microalgae is naturally produced Astaxanthin that can replace the current synthetically produced Astaxanthin used in salmon feed. For health reasons, consumers and regulators have started demanding replacing synthetic sources of Astaxanthin by natural sources. Brevel has created a novel microalgae cultivation system based on an internally illuminated photo bioreactor. Our system allows for microalgae production to become affordable and enables the stable cultivation of microalgae at a high capacity and resource efficient method. The unique approach lies in the internal volumetric illumination by concentrating and transporting sunlight by optical fibers. Brevel Ltd. was founded by three brothers in 2016 whose background is in microalgae production, physics and healthcare. The company is owned by the founders who invested €350,000 of their own savings as seed funding. Whilst the total market size for microalgae is almost €3 billion, we will first target the Astaxanthin market that had a €600 million size in 2016. Over 90% of this is manufactured synthetically due to the lower production cost. We would be the first to be able to compete with the synthetic alternative with natural Astaxanthin, which would greatly profit EU consumers who have access to eat healthier salmon. With the Phase 1 project, we want to study the feasibility of creating a small-scale and then large-scale production plant (with 5 and 50 production systems respectively). Once we succeed, our initial product will be Astaxanthin sold to salmon feed manufacturers at a price comparable to the current synthetic one.

Keywords: algae,microalgae,cultivation,bioreactor
Photochemistry and radiolabelling of gold(III) anticancer prodrugs (PhoRAu)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

The use of light to activate anticancer prodrugs is nowadays a reality in clinics around the world. Photodynamic therapy is an effective treatment for the localised destruction of cancer cells in a range of tissues and organs. Triggering the antiproliferative activity of chemotherapy agents with spatial and temporal control offers the advantage of reducing side effects and resistance. On the bases of the great success of metal-based drugs (e.g. cisplatin and its derivatives), photoactivatable metal complexes have been investigated for their potential in light-activated therapy. This promising class of molecules is characterised by outstanding photophysical and photochemical features, which can result in novel cytotoxicity mechanisms. Among transition metals, gold has shown promising anticancer features, however no attempt to exploit Au photochemistry for medicinal use has been reported yet. This project aims at exploring such potential by investigating the development of innovative photoactivatable gold complexes that can be used as effective prodrugs for photochemotherapy and simultaneously act as imaging agents. In particular, the research plan involves the synthesis of novel gold(III) carbene complexes which display dark stability in physiological conditions and high reactivity under light irradiation. These systems can undergo controlled Au(III)/Au(I) reduction in cell compartments giving new cell killing modes and therapeutic advantages. Strikingly, their remarkable synthetic and chemical versatility are ideal for combining therapy and imaging capabilities through labelling with 124-I radionuclide for Positron Emission Tomography (PET). Integration of such features has the potential to deliver innovative image-guided agents for cancer phototherapy.
Next Generation solid oxide fuel cell and electrolysis technology (NewSOC)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Italy,Italy,Germany,Spain,Estonia,Italy,Switzerland,Finland,Greece,Greece,Poland,Switzerland,France,Netherlands,United Kingdom,Denmark
Call: New materials, architectures and manufacturing processes for Solid Oxide Cells (H2020-JTI-FCH-2019-1, 2019)
Start date: 2020-01-01
End date: 2023-06-30
Duration (months): 42.0
Total project cost (EUR): 4999726.25
EU funding (EUR): 4999726.25
Participants: 16
Project status: SIGNED

The EU has the long-term goal to reduce greenhouse gas emissions by 80% to 95% compared to 1990 levels by 2050, mainly by introducing more shares of renewable energy sources in the EU energy systems. Solid oxide technologies (SOC: SOFC & SOE) are key enabling technologies for allowing for such integration. They are an efficient link between sectors: power, gas, heat. SOC can therefore emerge as key players in the energy transition in many concepts, such as • fuel/gas to power and heat at small to large scale, • energy storage through power to hydrogen/fuel, • utilisation and upgrading of biogas, • balancing of intermittent electricity from renewable sources through load following and reversible operation, and • central and decentral solutions for electricity and heat production. The NewSOC project aims at significantly improving performance, durability, and cost competitiveness of solid oxide cells & stacks compared to state-of-the-art (SoA). In order to achieve these goals, NewSOC proposes twelve innovative concepts in the following areas: (i) structural optimisation and innovative architectures based on SoA materials, (ii) alternative materials, which allow for overcoming inherent challenges of SoA, (iii) innovative manufacturing to reduce critical raw materials and reduction of environmental footprint at improved performance & lifetime. The NewSOC project will validate the new cells & stacks at the level of large cells with > 50 cm2 active area and short-stacks in close collaboration with industry thereby moving the technology readiness level from 2 to 4. Six major European SOC manufacturers are part of the consortium, representing a large range of SOC concepts and product & market strategies. Industry partners will take the lead for providing a path how to increase the TRL level beyond the project period towards TRL of 6. The NewSOC project will evaluate the new SOC materials and fabrication processes according to life cycle impact and cost assessment.

Keywords: solid oxide fuel cell,solid oxide electrolysis,reversible solid oxide cells
PHYSICAL BREAST ANTHROPOMORPHIC MODELS AND TECHNOLOGY FOR THEIR PRODUCTION (PHENOMENO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Bulgaria,Greece,Greece
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-05-01
End date: 2025-04-30
Duration (months): 48.0
Total project cost (EUR): 772800.0
EU funding (EUR): 772800.0
Participants: 5
Project status: SIGNED

Breast cancer is the most common incident form of cancer among women bellow seventy years of age. Early diagnosis is recognized as a critical factor that improves the chance of survival. In this research, anthropomorphic physical three-dimensional models of the breast are necessary, whenever a real tissue background is required to investigate the detectability of lesions, the performance of image processing algorithms, the reconstruction algorithms, the whole imaging chain and to replace real breast in virtual clinical studies. Manufacturing of such phantoms, however, is still not widely accepted due to cost and challenges of current 3D technology, limited number of suitable printing materials and availability of anthropomorphic computational models. This project aims to form an international network of organizations working on a joint research programme on the development of a complete technology for the production of physical models of the breast based on their computational models. The overall goal is to utilize partners’ experience and expertise to improve research, researcher training and skills and increase knowledge transfer from research to practice, which will be achieved through international and intersectoral collaboration and staff exchange. Expected results are related to new methodology for design of anthropomorphic breast phantoms, new methodology for producing materials and a methodology for development of a prototype of complete equipment and relevant technology for the fabrication of realistic breast phantoms, structures or part of them including health and cancerous tissues. An application in x-ray imaging is targeted. The consortium is with an expertise in rapid prototyping technology, modelling, validating and use of anthropomorphic phantoms, software and hardware design. Joining the efforts of engineers, anatomists, physicists, x-ray imaging specialists in this project will guarantee the successful implementation of the project aims.

Keywords: anthropomorphic breast models,3d printing materials,3d printing technology,breast ct,mammography,phase contrast,dual energy,monte carlo
Residue and Materials analyses of Early Iron Age ceramics, KwaZulu-Natal (RAMEKIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-06-09
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: SIGNED

Ancient food systems are often broadly simplified as a dichotomy between foraging and farming. This view, however, is increasingly challenged by archaeologists who argue that it does not apply neatly to all contexts in the past. In fact, it is likely that ancient societies followed a myriad of pathways to full food production. The goal of this project, led by Dr Emma Loftus, is to explore the archaeology of food in coastal south-east Africa, one of the last major regions on Earth to be occupied by agriculturalists. Specifically, I test the hypothesis that this southernmost extension of pioneer farmers in Africa, during the 1st millennium AD, was only made possible by a substantial shift in subsistence practice, namely an extensive reliance on wild coastal foods. This project aims to document the little-explored Early Iron Age archaeology of the northern KwaZulu-Natal coastline, extending to Mozambique. In conjunction with foot surveys, new excavations and scientific dating, RAMEKIN will undertake portable x-ray fluorescence (XRF) and organic residue analyses of the distinctive pottery made by early farmers. Portable-XRF reveals details of the ceramic composition and manufacture, indicating the wider relationships between these groups and others, including foragers and farming groups that appeared later in this region. Organic residue analyses of adsorbed lipids in cooking vessels will demonstrate the relative importance of coastal foods, such as shellfish, and animal domesticates, such as cattle, during this expansion phase. Altogether, RAMEKIN will facilitate new, nuanced perspectives on the many routes to food production in Africa, and will help to document the ways in which ancient agriculturalists dealt with episodes of environmental change, an increasingly pertinent topic given the evermore extreme and unpredictable climates faced by farmers today.

Keywords: african prehistory,early farming societies,archaeological science,southern africa,archaeological ceramics,organic residue analyses,portable xrf,radiocarbon dating,iron age
IN²LISBON - Innovative and Inclusive Lisbon (IN2LISBON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: SIGNED

"IN²LISBON - Innovative and Inclusive Lisbon" will investigate whether and how public policies and private investments that announce “innovation” in two neighbourhoods of Lisbon (Beato and Marvila), Portugal, promote or neglect the social inclusion of subaltern groups (women, ethnic minorities and low-income residents) and diversity in this city. These interventions are advertised as vehicles for the establishment of “innovative and creative industries”; for the creation of an “open, entrepreneurial city and a world reference”; and the consolidation of Portugal's status as a “cosmopolitan, open and innovative” country. However, the governance of this urban renewal process can also reproduce privileges and hierarchies, and even reinforce dynamics of urban segregation and inequality within the city. The Beato and Marvila area offers a privileged vantage point for the interests of this investigation, due to the clear articulation between urban renewal operations, on the one hand, and the existence of municipal and national symbolic strategies aimed at repositioning Lisbon and Portugal on the global map. Second, due to the scale and the fast pace that characterize this process in the context of a post-crisis economic recovery phase. Third, due to its timing: since the beginning of the current pandemic, many plans, deadlines and ideas for these projects are being discussed, and IN²LISBON will also be well positioned to contribute to this debate. The researcher will count on the contribution and partnership of the Institute of Social Sciences of the University of Lisbon (ICS-ULisboa), with excellent academic resources, namely the stimulating and productive research group Environment, Territory and Society. Based on this unique experience, the researcher intends to assume a more qualified and powerful position to continue his academic career in Brazil.

Keywords: urban renewal,urban regeneration,social inclusion,subaltern groups,policy public,symbolic representations,lisbon