Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Respiratory Disease Screening with Dark-Field Computed Tomography (RespeCT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-08-01
End date: 2022-07-31
Duration (months): 72.0
Total project cost (EUR): 2357212.5
EU funding (EUR): 2357212.5
Participants: 1
Project status: CLOSED

The grand goal of this proposal is to translate a recently explored and fundamentally different x-ray contrast mechanism, namely x-ray dark-field imaging, from present in-vivo small-animal proof-of-principle studies to a first clinical dark-field computed tomography (CT) prototype for future human diagnostics. Complementing this main technological development goal, we will explore the potential future clinical diagnostic application range of this technology by systematically screening multiple small-animal disease models. As one of the potentially most beneficial applications, we will particularly focus on one rapidly growing challenge in the healthcare sector, namely the early detection and screening of chronic obstructive pulmonary disease (COPD). For Europe, COPD has been estimated to affect 5-10% of adults over 40 years of age. This translates to 12-25 million individuals affected by COPD in the European Union. If dark-field CT imaging can substantially improve early diagnosis and thus prompt appropriate therapeutic treatment in these patients, this project has the potential to prolong and improve the lives of millions of Europeans. Further, the cost of COPD to society in Europe could be decreased by billions each year, if COPD – with emphysema as one of its main components – could be accurately detected, effectively treated, and stabilized at early stages of the disease. Besides COPD, we will explore the potential clinical benefit of dark-field CT for better diagnosis of pulmonary fibrosis, lung cancer, asthma, pneumothorax, acute lung injury, bronchopulmonary dysplasia, inflammation, and radiation-induced lung injury as a consequence of radiation therapy after lung cancer. The ambition to deliver more than just an academic proof-of-principle development, but a clinically usable new imaging device for a broad medical community is underlined by a firm commitment of an industrial partner (Philips) to support this project, should the proposal receive funding.

Keywords: chronic obstructive pulmonary disease,lung fibrosis,lung emphysema,lung screening,computed tomography,biomedical imaging,x ray imaging,x ray phase contrast,dark field contrast
Investigating Pleistocene population dynamics in the Southern Caucasus (TransCause)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Israel,United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1499875.0
EU funding (EUR): 1217143.75
Participants: 2
Project status: SIGNED

Over the past 25 years, knowledge of the origins, evolution and diversity of our species has increased dramatically. Yet, the behavioural mechanisms enabling their global expansion and ability to cope with ever-increasing ecological diversity are still not fully explored. Armenia, a little studied biodiversity hotspot of Eurasia, is an ideal natural laboratory for testing models of climatic impact on hominin settlement patterns and population dynamics due to its location at the crossroads of the Pleistocene hominin world. TransCause aims to expand the framework of population dynamics by building an intra-regional comparative database of Paleolithic occupations incorporating biological evolution of macro-and micro mammals using ancient DNA, as well as establishing refined environmental frameworks. The TransCause project focuses on two main research questions, what are the impacts of long-term climatic and environmental changes on hominin behavioural repertoire and population dynamics? And what are the adaptations of Pleistocene hominins to changing seasonal resource availability in the landscapes of Armenia? Past hunter-gatherer’s social networks would be studied as a possible solution for populations coping with such terrains. The results of the project will test the presence or absence of population resilience over time; moreover, it will evaluate hypotheses on hominin behavioural responses to variation in resource availability using multi-scalar models; ultimately, those results will examine and compare the population dynamics of humans, large mammals and small mammals against the backdrop of paleoenvironmental oscillations. Examining the ecological tipping point of survival in both hominids and mammals will change the way in which we grasp hominin population dynamics. This project will be of pivotal importance for understanding the economic, demographic and social mechanisms behind the behavioural elasticity which enabled our species to expand globally.
Role of Id4 in the adult subventricular zone of normal and injured brain (ID4)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-12-04
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The aim of this proposal is to propose a scientific research project and a training plan for Dr. Brenda Rocamonde. The scientific research project aims to understand the function of the transcriptional regulator Id4 in the adult subventricular zone (SVZ) under physiological and pathological conditions. The SVZ is one of the largest neurogenic niches of the adult brain, generating new neurons from neural stem and progenitor cells, throughout adulthood. This region is activated after brain injury, such as ischemic stroke. Inhibitor of DNA binding 4 (Id4) is a transcriptional regulator that acts by antagonizing transcription factors. In the developing brain, Id4 is required for neural progenitor cell proliferation and differentiation. However, the function of Id4 in the adult SVZ has not been reported. We have observed that Id4 is expressed in neural stem cells and cells of the neuronal lineage in the adult SVZ. We propose to use in vivo approaches to (i) determine Id4 function in the SVZ by loss and gain of function approaches, and (ii) evaluate its role in the response of the SVZ to ischemic stroke, a major cause of disability in Europe. This project, undertaken in an international research center and carried out by a talented fellow will provide insights into the mechanisms underlying the regulation of adult neurogenesis in the normal and injured brain. In addition, we are proposing a career development plan for Dr. Rocamonde that includes training on scientific and transferable skills. This plan will widen Dr. Rocamonde’s competences and provide her with the tools to become a leading independent researcher.

Keywords: subventricular zone,brain injury,transcription factor
Immigrant Activity-Space Segregation: Spatio-Temporal Patterns of Assimilation and Separation in Barcelona (IASS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

This project will deepen society’s understanding of immigration while enabling a young, experienced researcher to acquire new skills by collaborating with a well-established European research group with a long record of high quality academic output. The project will help illuminate the lives of immigrants in Barcelona, focusing on their use of space and time as a way to understand the process of assimilation and barriers to social and economic inclusion. Drawing on the expertise of UPF’s Interdisciplinary Research Group on Immigration (GRITIM-UPF), the researcher (John Palmer) will interview and observe a panel of immigrants over time to learn about their routines and about the places and people with which they come into contact as they go about their daily activities. The researcher will use newly-developed mobile phone geolocation methods to quantify systematic differences in the spatio-temporal distributions of immigrants and natives, while using traditional qualitative approaches to analyse the social significance of these segregation patterns.

Keywords: immigration,segregation,demography
Innovation Associate for OIP (IA for OIP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Netherlands
Call: European SME innovation Associate - pilot (H2020-INNOSUP-2020-02, 2020)
Start date: 2021-01-01
End date: 2021-12-31
Duration (months): 12.0
Total project cost (EUR): 196428.57
EU funding (EUR): 137500.0
Participants: 1
Project status: CLOSED

Research suggests that there is a market demand for third-party intelligent service management platforms. Video Service Providers need new tools to reduce their operational costs and improve end-user quality of experience through efficiencies in issue detection and resolution. Divitel sees great potential in the automation of customer care as well as the integration of AI enabled software in the Television (TV) domain. Most of the TV operators make a huge amount of revenue with their customers, but even today, customer service is very poor. Customer complaints are not answered and responded to in a proper way, the fixing time for open bugs or tickets can take up to a few weeks to months and in the end, they do not optimize their internal infrastructure based on current system failures. Also The road to get video content from its creation to the device is long. Operators, content providers and broadcasters must not only investigate the many different types of technology, employ them effectively, but also to operate their services in an efficient way, allowing faster times to change with increasingly lower margins of error. While trying to implement this, they all have limited resources, in an industry that is becoming more and more hyper competitive. Divitel wants to change this and truly believe that the new trend of AI (Artificial Intelligence) will also take place in this industry. To address this problem, Divitel wants to build and offer an Intelligence Operations Platform (IOP) to the marketplace. The platform enables the delivery of products and services such as Monitoring, Analysis and Managed Operations. It will rely on the latest research in Machine Learning (ML) and Artificial Intelligence (AI) which runs on the top of the knowledge graph architecture and is optimized to take full advantage of its underlying data structure. Service Providers will take advantage of insights coming from the Knowledge Graph to solve challenges such as personalizing

Keywords: intelligence operations platform
Self Organization in Competition and Diversity (SOURCE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Denmark
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-09-01
End date: 2023-02-28
Duration (months): 66.0
Total project cost (EUR): 2211015.0
EU funding (EUR): 2211015.0
Participants: 1
Project status: CLOSED

At all scales, biology presents an astounding diversity of discrete states or species that coexist with each other long times. At the sub-cellular scale, molecular competition and positive feedback maintain cells in specialized epigenetic states over very long time, allowing for embryonic development of complex multicellular organisms. On larger length scales, stable yet dynamic ecosystems emerge from competition between different species. This general pattern calls for research with a focus on diversity, and how competition can act as its "engine". Statistical mechanics of complex systems provides a framework for studying universality of collective and cooperative phenomena, usually through repeated action of identical agents. I want to extend this methodology by allowing these agents to diversify. And I want to focus on the emerging diversity as a main measure of complexity. I will explore the origin and sustainability of diversity, using model systems from biology. The hypothesis is that competition is the main driver of diversity, with randomness and cooperation playing auxiliary roles. The research will be guided by agent based models of biologically relevant examples of competition and diversity: - Patterns of Competitive Regulation - Competition as an Engine of Ecosystem Diversity - Diseases and host Immunity. These categories will include computational aspects of gene regulation, sustainable structures of ecosystems, mechanism of speciation facilitated by competition and defense systems including the interplay between diseases and host immune systems. My aim is both multidisciplinary and ambitious: To create a new paradigm that explicitly measures self organization in terms of its resulting diversity.

Keywords: living biological systems,competing states,conceptual models
Energy and Seismic AFfordable rEnovation solutions (e-SAFE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Innovation actions
Countries involved: Italy,Italy,Italy,Austria,Cyprus,Norway,Greece,Belgium,Türkiye,Netherlands
Call: Decarbonisation of the EU building stock: innovative approaches and affordable solutions changing the market for buildings renovation (H2020-LC-SC3-EE-2019, 2019)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 4591044.75
EU funding (EUR): 3996778.5
Participants: 13
Project status: SIGNED

e-SAFE defines and develops a market-ready deep renovation system for non-historic buildings, whose ability to uptake the EU market relies on the combination of decarbonization goals with earthquake safety (where applicable), indoor comfort, reduced implementation time and cost, affordable financial options, reduced occupants’ disturbance, increased aesthetic and functional attractiveness. This is reached through an iterative process based on a multidisciplinary methodology, where traditional modelling and experimental research are integrated with tools for promoting financial feasibility, knowledge co-production, mutual learning and public engagement. The result is a new deep renovation system that benefits from the full integration between technological innovation and process-based innovation. From a technological standpoint, e-SAFE integrates TRL5-6 technologies within a TRL8-9 upscaled framework, deployed and validated through 3 large scale pilot projects. The output is an abacus of innovative, tailorable, integrated solutions for energy-efficient deep renovation, with recyclable bio-materials and increased seismic resistance. The e-SAFE technical systems also enhance indoor comfort while significantly reducing primary energy demand. Market uptake and public interest in deep renovation are than pursued via 3 process-based innovations: 1) a co-design protocol for future e-SAFE exploiters, to fully engage their customers in the finalization of renovation design, assisted by a newly developed ICT-based decision making tool; 2) an original dedicated value chain, where e-SAFE-related royalties are used by a new one-stop-shop financing entity for broadening deep renovation opportunities by providing to potential clients tailored financial solutions; 3) the generation of a public engagement protocol that makes every e-SAFE-based project an occasion to raise public awareness on the importance of decarbonization and seismic safety, while enhancing market opportunities.

Keywords: decarbonisation,affordable deep renovation,seismic upgrade,innovative financial schemes,stakeholders involvement,prefabricated components
Tracing Hominin Occupations of and Migrations through the Levant: Reviving Paleolithic Research in Lebanon (REVIVE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1999875.0
EU funding (EUR): 1999875.0
Participants: 1
Project status: SIGNED

Our species evolutionary success story is intriguing. For over a century, we have been trying to formulate a narrative for the evolutionary and migration steps our ancestors took and made us who we are today. Several decades ago, our narrative for our lineage’s dispersals from our place of origin, Africa, across the globe, was based on two separate big waves: one with Homo erectus at ca. 1 million years ago and the second with modern humans 60-50 thousand years ago. However, recent archaeological, paleoanthropological, and genetic evidence has forced us to alter this narrative to one which favors more dynamic geographic movements of hominins over several millions of years. Yet, although we seem to have now framed the overall picture of our narrative, its details remain mostly blurred leaving many chapters unfinished and their events highly debated, particularly those related to the number and timing of the dispersal events, the specific hominin taxa involved in each, and the effects of factors like technology, climate, and interactions among hominin populations, in shaping these events. As the bridge that connects Africa to the rest of the world, the Levant is an ideal place to look for answers. At its heart is Lebanon, a small country exceptionally rich in Paleolithic archaeological material reminiscent of a dense hominin occupation spanning the entirety of this period. Yet, Lebanon’s rich Paleolithic record remains undiscovered and its potential is mostly forgotten since Paleolithic archaeological exploration in the country was forcefully stopped in its early infancy by the outbreak of the civil war (1975). REVIVE, a highly ambitious, groundbreaking project, will form the first ever large-scale and systematic archaeological/paleoanthropological project to be conducted on Lebanon’s Paleolithic. It will, finally after 45 years, revive Paleolithic research in the country and use its wealthy record to start filling in the gaps in our ancestors’ dispersals narrative.

Keywords: hominin dispersals,neandertals,early modern humans
'Marriage and Cultural Diversity in the German Empire' (MARDIV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-19
End date: 2019-09-18
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

How do putatively universalistic norms with global reach relate to politics of diversity and pluralism within national societies? By assessing the legal regulation of marriage and the family, ‘Marriage and Cultural Diversity in the German Empire’ (MARDIV) will advance significantly our understanding of the global diffusion of legal and social norms. The tension between global norms and cultural specificity has come to a head during the first decade of the 21st century. Not only has the presence of Muslim immigrants raised the profile of debates over the diversity of personal status law throughout Europe. The legalisation of same-sex marriage in many European countries has also pointed to a seachange in public views about the family and the role of the state in preserving it. How do legal transplants operate in family law? Can we discern particular patterns of diffusion in specific historical circumstances? And, how do 19th- and early 20th-century developments in family law remain relevant today? MARDIV addresses these questions by scrutinizing the historical roots of recent debates. 19th- and early 20th-century Germany offers a particularly relevant case study because it was a laboratory of both modernity and cultural diversity in which questions of global reach, national identity, regional particularity and local traditions came into especially sharp relief. MARDIV suggests that an understanding of Germany’s past experiences can enable us to better analyse Europe’s present. To this end, the project employs an innovative interdisciplinary methodology linking history and sociology and a novel theoretical framework. The main empirical aims are twofold: to shed light on the historical roots of contemporary European debates about the family, and to reflect on broader processes of the global diffusion of legal and social norms. The primary aim is the PI’s advanced training in historical sociology and project management so she can reach a position of research leadership.

Keywords: religious and cultural diversity,migration,marriage,family,germany,empire,human rights,international norms,modern history,historical sociology,globalization,gender,europe