Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Decoding User Experience Qualities with and through Technology over Time (UXCODES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-10-01
End date: 2013-09-30
Duration (months): 24.0
Total project cost (EUR): 200549.6
EU funding (EUR): 200549.6
Participants: 1
Project status: CLOSED

User Experience (UX) is a complex, but promising concept in the field of Human-Computer Interaction (HCI). This Marie Curie project aims to identify the key “UXCodes”, in particular to decode the UX qualities for a better ICT-enabled life for older people, following a humanistic, dialogical approach. The key premise is that people act on the basis of social relationships, which influence the quality of an experience with a technology. Gained insights are translated into for practical guidance for designers and generalized by applying experience-centered theories and research methodologies. In addition, the pattern approach is applied as valuable way to preserve knowledge for practitioners in future projects, and optimising technological innovation and opportunity for older people to enrich their lived experience with and through technology. The European Union also recognized the relevance of this topic by focusing research on “Quality of Experience (QoE)” within the FP7 ICT Work Programme 2009-10 and calls for research into “more natural, intuitive and easy-to-use interfaces and new ways to interact with technology, machines, devices and other artefacts.” The proposed research will underpin the essential priority of ICTs in supporting daily life in today's digital society.

Keywords: humanities,social sciences,technological sciences
Monolithic Frequency Comb Generators In the Mid-Infrared (IRCOMB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-10-01
End date: 2013-09-30
Duration (months): 24.0
Total project cost (EUR): 181101.6
EU funding (EUR): 181101.6
Participants: 1
Project status: CLOSED

Optical frequency combs have become pivotal tools in a wide range of studies, from metrology, gas sensing to astronomy. In 2007 the host laboratory has demonstrated an entirely new approach to generate frequency combs from optical micro-resonators. The physical process responsible for the comb generation is parametric four-wave mixing.The micro-resonator frequency combs not only represent considerably reduction in size, complexity and power consumption, but moreover, the small circumference of optical micro-resonators enable for the first time to generate frequency combs with repetition in the technologically and scientifically interesting range of above tens of gigahertz. The high repetition rates have potentials in applications such as high capacity telecommunications and astronomical spectrometer calibration. The main experimental goal of this proposal is to generate frequency combs in the scientifically and technologically significant "molecular fingerprint" mid-infrared spectral region in micro-resonators made of crystalline materials. The crystalline materials feature exceptionally low loss from UV to mid-infrared, and resonators with cavity finesse up to 1 million have been successfully fabricated in the host group. It is envisioned that broadband combs in the mid-IR can be generated in such micro-resonators, and such a mid-IR comb will greatly facilitate molecular spectroscopy, enables multi-heterodyne spectroscopy in the mid-IR and will also have potential in astronomical spectrometer calibration. The applicant is a female scientist who has obtained her undergraduate degree in Taiwan and her PhD at Harvard University (USA) in the group of Quantum Cascade Lasers pioneer Federico Capasso. She started her postdoctoral work in September 2009 at the Max-Planck Institute for Quantum Optics in the host group in the division of Prof. Theodor Haensch. Her experience makes her the ideal candidate to carry out the proposed research project.

Keywords: physical sciences,applied optics,experimental physics,metrology
CloudIX: Cloud-based Indexing and Query Processing (CLOUDIX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Norway
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-09-01
End date: 2013-08-31
Duration (months): 24.0
Total project cost (EUR): 212225.6
EU funding (EUR): 212225.6
Participants: 1
Project status: CLOSED

The advent of cloud computing comprises a new paradigm that entails a large number of low-end processors that perform parallel processing of (usually data-intensive and resource-demanding) computing jobs. This is particularly appealing for a wide variety of data-intensive applications, including scientific data management, analysis and mining of complex data, and internet-scale service provisioning. Nevertheless, processing complex queries in the cloud is still in a primitive stage, largely relying on the concept of map-reduce, without inherent indexing mechanisms that can boost the performance of query processing. In contrast, database research prides itself on scalable techniques for advanced query processing. CloudIX intends to transfer knowledge from data management technology to the cloud infrastructure, in order to support advanced query processing. To this end, CloudIX aims to propose a generic, distributed, dynamic and adaptive indexing framework for handling multidimensional data in the cloud. Capitalizing on this indexing infrastructure, CloudIX will present novel efficient algorithms for processing advanced query types, such as range, nearest-neighbor, top-k, rank joins, and skyline queries. Furthermore, CloudIX will propose new economical cost models that need to be tightly integrated in the process of query optimization. The research results of CloudIX are expected to act as a catalyst that attracts applications that rely on advanced query processing to be moved to the cloud. As a showcase scenario, two applications will be deployed on top of CloudIX, one related with scientific data management, to demonstrate the feasibility and efficiency of the proposed framework.

Keywords: cloud data management,indexing,query processing
Multi-sensing polymer transistors for in vivo recording (MULTISENS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-09-01
End date: 2013-08-31
Duration (months): 24.0
Total project cost (EUR): 185748.0
EU funding (EUR): 185748.0
Participants: 1
Project status: CLOSED

The computational power of the brain arises from the complex interaction and cooperation of a large number of neurons embedded in a functional network. Thus, a direct investigation of the temporal dynamics of neuronal populations (and structures) must address the simultaneous observation of multiple neurons. Most breakthroughs in our understanding of the basic mechanisms of information processing in the brain have been obtained with local field potentials (LFPs) and single neuron recordings in freely moving animals. Those measurements have been performed with silicon probes, but the process is prone to errors, since this technology suffers from several limitations, directly related to the materials used for the probe fabrication. In particular, the electrodes are not biocompatible and create tissue scars, they are rigid, and thus cannot compensate for small brain movements (as a result, a given cell cannot be recorded over extended periods of time). More important, information is only electrical and there is no information regarding how the system uses metabolites or how neuronal activity maintains the appropriate level of metabolites to operate properly. The purpose of MultiSENS is to develop a new generation of chronically implantable biocompatible probes displaying multi-sensing recording sites for monitoring brain activity. The most recent technology - organic electronics - will be used to address this issue. In particular, organic electrochemical transistors (OECTs) will be used as sensing sites for metabolites and ion current in situ measurements, thanks to their peculiar properties of strong ion-to-electron transduction, biocompatibility and mechanical flexibility. MultiSENS will make available multi-sensing probes capable of simultaneous in vivo recording of LFPs and ion currents/glucose concentration, delivering an advanced biomedical tool that will have a major impact on neuroscience research.

Keywords: technological sciences,health sciences,physical sciences,organic electronics,bioelectronics
IN-SITU FILLING OF CARBON NANOTUBES WITH METALS (MECARTUBES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-10-01
End date: 2013-09-30
Duration (months): 24.0
Total project cost (EUR): 200049.6
EU funding (EUR): 200049.6
Participants: 1
Project status: CLOSED

Metal-filled carbon nanotubes (CNTs) have attracted intense attention in recent years especially with view to applications in biomedicine such as drug delivery systems. This project concerns the development of in-situ filling CNTs with metals. Different magnetic metals such as Fe, Co, Ni and their alloys will be encapsulated in the inner cavity of the CNTs during growth. In order to achieve this objective, novel carbon vapor deposition experiments for the continuous process of filling CNTs will be explored. The methods proposed have the advantage that the growth and filling of the nanotubes take place simultaneously. The transition from lab to a large scale production will be explored. They will be based on the pyrolysis of metal-organic compounds and catalytic pyrolysis varying catalyst concentration in conjuction with filling facilitating compounds. The influence of the processing parameters (i.e deposition time, reaction temperature or influence of the catalyst particles) on the structure and magnetic properties will be studied in order to elucidate important parameters for the controlled mechanism formation and encapsulation of metallic particles. Structural and chemical analysis of metal-filled CNTs will be carried out by means of scanning and transmision electron microscopy, electron energy-loss spectroscopy or raman spectroscopy. Magnetic properties will be also evaluated. Functionalization of CNTs is the precondition for their application in medicine. In this project, functionalization of the surface of filled-CNTs will be explored mainly by covalent functionalizations through oxidation with strong acids and employing the 1,3 dipolar-cycloaddition mechanism. As part of the last activity of the research, the project will overcome preliminary tests about the binding of therapeutic molecules with some kind of pharmacological activity for the treatment of complex diseases where activity is required at specific sites in the human body.

Keywords: technological sciences,materials technology,nanobiotechnology,biomedical engineering
Advanced epidemiological analysis of Mycoplasma hyopneumoniae infection in pigs (EPIDEMIOLOGY OF MHYO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-08-01
End date: 2013-08-31
Duration (months): 24.0
Total project cost (EUR): 192849.6
EU funding (EUR): 192849.6
Participants: 1
Project status: CLOSED

Mycoplasma (M.) hyopneumoniae is the causative agent of porcine enzootic pneumonia (EP). This disease, leading to reduced weight gain, reduced feed conversion and increasing use of antibiotics, is one of the major health problems in the pig production throughout Europe. The epidemiology of EP is influenced by several factors including management, hygiene, virulence of the M. hyopneumoniae strain and other factors. In order to increase the epidemiological understanding of EP, five different studies supervised/performed by Dr. Heiko Nathues were conducted during the last five years at the Field Station for Epidemiology, Univ. Vet. Med. Hannover, Germany. The studies addressed the influence of (a) environment, (b) strain variation, (c) time of infection, (d) occurrence of infections among suckling pigs and (e) prevalence among breeding pigs. Initial results from descriptive data analysis have already been published. The objectives of the proposed project are 1) to improve the understanding of EP epidemiology by analyzing existing data collected by projects of Dr. Nathues using a multivariable approach, and 2) to develop a compartmental model of the within herd transmission of M. hyopneumoniae which will allow assessing the impact of different husbandry system and potential control measures. As a result of the project, the impact of targeted intervention measures can be assessed, resulting in prevention of clinical disease, reduction of pain and suffering of animals, and in refraining from the use of antibiotics. The expected outcome is a considerable increase of the animals' health and welfare as well as a considerable reduction of the use of antimicrobial drugs in pig production.

Keywords: bacterial pathogens of animals,pig,mycoplasma hyopneumoniae,infection,epidemiology,statistics,review
Impact of adjuvants on T cell differentiation after Influenza Vaccination analyzed at the Single Cell Level (TCDIFLU)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-03-01
End date: 2013-02-28
Duration (months): 24.0
Total project cost (EUR): 180084.0
EU funding (EUR): 180084.0
Participants: 1
Project status: CLOSED

Mutating viruses and resistance to drugs are the major challenges to overcome in influenza (flu) prevention and treatment. Virus-neutralizing antibodies are the key for protection against flu infection, but flu-specific CD4+ and CD8+ T cells play a significant role by providing help to B cells and in viral clearance, respectively. There are many vaccines against flu infection approved for human use. The generally effective seasonal vaccines, however, have a number of deficiencies, including the need to repeat the injections every year with a newly updated vaccine, which provides only antibody-dominated subtype-specific protection. Adjuvants are used to enhance the immune response to a vaccine. They lead to different types of cell-mediated immune responses. The T cell type (Th1, Th2, cytotoxic) and the magnitude of the immune response discriminate between viral clearance and immunopathology. Particular T cell subpopulations (like Th1 IFN-γ or CD8+ perforin or Fas expressing cells) may be responsible for protection after infection or vaccination and may give correlation to protective adjuvants. Studies of T cells using assays analyzing entire cell populations are not suitable to uncover these cell populations. We propose a detailed T cell differentiation profiling of CD4+ and CD8+ T lymphocytes at the single cell level after flu vaccination using the quantitative single cell multiplex RT-PCR method. Individual T lymphocytes purified from the vaccination site draining lymph nodes will be analyzed for the presence of up to twenty important differentiation markers. The results will be verified by additional methods, like flow cytometry or confocal microscopy. This project will reveal the presence of T cell subpopulations possibly correlated to protection after flu infection with mouse-adapted PR8 influenza strain or immunization with seasonal flu vaccine, with special consideration on the effect of adjuvants.

Keywords: health sciences,medical sciences,immunology,infections,vaccines
Signaling Mechanisms Intersecting Histamine Receptors and Pattern Recognition Receptor Activation in Dendritic Cells (DC-SIGNAL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-06-01
End date: 2013-05-31
Duration (months): 24.0
Total project cost (EUR): 177601.6
EU funding (EUR): 177601.6
Participants: 1
Project status: CLOSED

The immune response is a tightly regulated process which normally results in protection from infection and tolerance of innocuous environmental antigens. However, in allergy and asthma, the activated immune response results in a chronic pro-inflammatory state characterized by T cell Th2 polarization to normally well-tolerated antigens resulting in tissue inflammation and tissue remodeling. Dendritic cells (DCs) are essential for inducing activation and differentiation of effector CD4+ and CD8+ T cells in response to antigens, and it is well established that these cells play a pivotal role in the initiation and maintenance phase of inflammatory responses. However, the molecular basis for aberrant DC activation within inflamed tissues is poorly defined. The hypothesis to be tested in this proposal is that pattern recognition receptor (PRR) activation in the context of histamine receptor (HR) stimulation skews the DC activation program resulting in aberrant T cell polarization. Human-derived DCs and T cells from humans will be utilized in order to ensure the results obtained are relevant in vivo. This project is a significant leap forward as it combines multiple, clinically relevant, triggers of DC activation in a co-ordinated research program, which will ultimately result in the identification of new therapeutic targets for allergy and asthma patients. The original feature of this proposal relates to the elucidation of the key molecular checkpoints intersecting HR and PRR pathways, in myeloid and plasmacytoid DCs from allergy and asthmatic patients. SIAF is well placed to perform these studies as SIAF members have well-established track records in elucidating novel immunological mechanisms in allergy and asthma. The public health implications of this proposal are immense as development of novel DC modifying compounds allows clinicians to target a range of inflammatory diseases such as asthma, allergy, autoimmune disorders and inflammatory bowel disease (IBD).

Keywords: health sciences,dendritic cells,asthma,histamine receptors,prrs
Empires of the Visual - public visual economies in Southern Africa and the genesis of African modernities (VISUALEMPIRES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2011-07-01
End date: 2014-06-30
Duration (months): 36.0
Total project cost (EUR): 227851.1
EU funding (EUR): 227851.1
Participants: 1
Project status: CLOSED

The project aims to explore and synthesize the history of modern public visual production and consumption in Southern Africa. It is based on the assumption that the varied Southern African visual economies are framed and patterned by a South African claim to hegemonic control of visual production and communication. As in many other realms of society the country's imperial outreach on its neighbors remains very tangible up to date. Hence the project focuses on what has recently been termed the South African empire, an imperial formation including South Africa as the metropole and Namibia and Mozambique as its main peripheries. While the genesis of these relations of power, the discursive interdependencies, and South Africa’s attempt to homogenize visual culture form the point of departure of this project, the various subaltern voices and dynamics that counter the hegemonic claim are also considered. The project will hence engage in an inquiry of the complex history of entangled visual economies throughout an enormous geographical and socio-political space, which is Southern Africa. Three particular domains of visual production will help to illustrate this point: landscape design, poster histories and struggle photography, all of which allow the consideration of various sites and spaces of visual representation and communication in the public domain, and of different agents who become active within the visual cultures the project is concerned with. Methodologically the research is based on archival studies including known and hidden archives, on reception studies with focus groups in the three countries, as well as on the synthesis of various existing case studies and literature.

Keywords: southern africa,south africa,mozambique,namibia,history,visual studies,cultural studies,geography,landscape,photography,posters,public space,colonialism,post-colonialism,modernity
Dynamic Combinatorial Chemistry at Lipid Membranes (DYNAMEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-05-21
End date: 2014-05-20
Duration (months): 24.0
Total project cost (EUR): 184040.8
EU funding (EUR): 184040.8
Participants: 1
Project status: CLOSED

Molecular recognition at bilayer membranes is key to many vital processes in biology, yet notoriously difficult to study. Aim of this project is to introduce a new technique to this field: dynamic combinatorial chemistry. We propose to adapt reversible thioester chemistry to this end and use it for two different purposes: (i) Discovering new synthetic receptors that are optimized for operating at the bilayer interface. This should lead to new fundamental insights into what differentiates molecular recognition at the lipid bilayer interface from the corresponding process in solution. (ii) Unraveling the mode of action of gramicidin antibiotics through covalent capture of the self-assembled superstructures formed upon incorporation of this compound in the bilayer membrane.

Keywords: supramolecular chemistry,dynamic combinatorial chemistry,bilayer membranes,molecular recognition,antibiotics