Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Predictix ™ - a user-friendly procedure that analyses genomic, clinical and demographic data to generate a personalized report on the efficacy of antidepressants and their side effects (Predictix)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 3545737.5
EU funding (EUR): 2482016.25
Participants: 1
Project status: SIGNED

The World Health Organization recognizes mental disorders as one of the most significant public health challenges worldwide as measured by prevalence, burden of disease and disability, and depression as the world’s leading cause of disability. In EC and WHO action plans it is clearly requested that mental health services can be accessed without unfair financial barriers and that treatments are made available on criteria of both efficiency and financial fairness. Personalised medicine is the fastest, most economic and optimized solution to the depression treatment problem. The current push for a cost effective personalised medicine based on IT solution will also help with the commercialisation of our Predictix™ platform. The platform will allow medical practitioners to have up-to-date and accurate knowledge on each case and improve the care that patient receives, with an economic revenue too. Our solution allows for better delivery of available treatments – noted as a vital factor for increasing remission. Taliaz was founded in 2012 by Dr. Dekel Taliaz and Oren Taliaz. Our mission is to set a new standard in personalized medicine improving quality of life for patients suffering from depression. Taliaz takes advantage of in-house expertise in genetics, data science and central nervous system related disease with the advancements in genetic sequencing and machine learning technologies, to develop leading personal medicine proprietary IP solutions for depression. Our future vision is to use Predictix™ also as a decision support tool for common health concerns such as ADHD and Anxiety. The SME Instrument project perfectly fits our strategy and vision by enabling a fast finalisation of the platform development and by providing us the resources necessary to demonstrate the benefits of Predictix™ through a large clinical study.

Keywords: depression,predictive analysis,antidepressants,artificial intelligence,machine learning
Understanding the Material Culture of Islamic Paper and Inks (ISLAPAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Slovenia
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-10-10
Duration (months): 24.0
Total project cost (EUR): 162040.32
EU funding (EUR): 162040.32
Participants: 1
Project status: SIGNED

Islamic paper, i.e. paper produced in the Islamic cultural realm, is a particularly underexplored aspect of Islamic material culture. Although paper was first produced outside China already in 750 AD, our knowledge of historic paper and ink is dominated by research into Western papermaking. However, Islamic paper and inks are particular in their use of polishing practices, use of starch as a filler, use of dyes and use of specific inks. ISLAPAP aims to fill the knowledge gap through material science research of both reference material collections and actual manuscripts, and through archival research into paper- and ink-making recipes in medieval and early modern art-technological sources and treatises. ISLAPAP will further illuminate historic papermaking practices through experimental evidence, which will benefit manuscript scholars. Material science will be used to explore the durability of Islamic paper in order to develop preventive conservation advice. It is namely not known how the typical Islamic papermaking practices of polishing and starch sizing affect the stability of the cellulosic support, and it is currently not known how corrosive Islamic inks are. This knowledge will be of use to libraries and archives hosting Islamic paper collections globally. The research will be carried out at University of Ljubljana as the Host institution with world-leading expertise in heritage science, which will be complemented with the Fellow's skills in archival research and conservation research. The Fellow will study medieval and early modern archival art technological sources and treatises with references to papermaking and ink manufacture. An intensive training programme is planned that will allow the Fellow to develop into a world-leading researcher in the field of Islamic paper collections, supported by a communication and dissemination plan ensuring excellent global impact.

Keywords: islamic paper,history of technology,heritage science
Synaptic Tagging and Capture: From Synapses to Behavior (STC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2022-03-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

It is shown that long-term potentiation (LTP) is the cellular basis of memory formation. However, since all but small fraction of memories are forgotten, LTP has been further divided into early LTP (e-LTP), the mechanism by which short-term memories are formed, and a more stable late LTP (L-LTP), by which long-term memories are formed. Remarkably, it has been shown that an e-LTP can be stabilized if it is preceded or followed by heterosynaptic L-LTP. According to Synaptic Tagging and Capture (STC) hypothesis, e-LTP is stabilized by capturing proteins that are made by L-LTP induction. The model proposes that this mechanism underlies the formation of late associative memory, where the stability of a memory is not only defined by the stimuli that induce the change but also by events happening before and after these stimuli. As such, the model explicitly predicts that a short-term memory can be stabilized by inducing heterosynaptic L-LTP. In this grant, I will put this hypothesis into test. Specifically, I will test two explicit predictions of STC model: 1) A naturally formed short-term memory can be stabilized by induction of heterosynaptic L-LTP. 2) This stabilization is caused by the protein synthesis feature of L-LTP. To do this, using optogenetics, I will engineer a short-term memory in auditory fear circuit, in which an animal transiently associates a foot shock to a tone. Subsequently, I will examine if optogenetic delivery of L-LTP to the visual inputs converging on the same population of neurons in the amygdala will stabilize the short-term tone fear memory. To be able to engineer natural memory by manipulating synaptic plasticity I will develop two systems: 1) A two-color optical activation system which permits selective manipulation of distinct neuronal populations with precise temporal and spatial resolution; 2) An inducible and activity-dependent expression system by which those neurons that are activated by a natural stimulus will be optically tagged.

Keywords: synaptic tagging and capture,memory formation,cellular consolidation,synaptic plasticity
AerIal RoBotic technologies for professiOnal seaRch aNd rescuE (AirBorne)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Italy,Germany,Italy,Sweden,United Kingdom
Call: Advanced robot capabilities research and take-up (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2021-04-30
Duration (months): 40.0
Total project cost (EUR): 2931193.75
EU funding (EUR): 2295998.13
Participants: 6
Project status: CLOSED

AirBorne is a high tech social innovation targeted to Search and Rescue (S&R) organizations operating in mountains to increase safety in tourism and leisure activities key for European mountaineer communities. The goal of AirBorne is twofold: From one hand the objective is to develop at TRL8 a few selected robotic aerial technologies for professional S&R teams/associations with a specific focus on quick localization persons buried by avalanches by leveraging the successful EU FP7 project SHERPA (www.sherpa-project.eu) in which specific application contexts have been characterized and products for S&R in the Alps have been developed at TRL5. The robotic technologies developed, then, will constitute the initial “technological seed” on which an innovative ICT technology service network will be constituted at European level with the final goal of feeding professional S&R teams/associations with effective ICT technologies by creating a business opportunity and contributing to address several shortcomings of current operations. Actions to set up of the network and to promote its proliferations are the further objective of AirBorne. The partnership includes CAI, one of the leaders in Alpine Search and Rescue organization with the role of end-user and first “seed” of the network, XLog and RECCO, the manufacturers of the key components of the most reliable personal safety equipment for avalanche incidents, ATECH, the company that developed at TRL5 the SHERPA aerial technologies, and PV one of the first companies in Europe active on the development of social innovation projects. The action is coordinated by UNIBO, bringing into AirBorne specific skills in automatic control and Innovation Management. AirBorne develops a clear business proposition to address an “orphan market” and overcome the constraints determined by demand fragmentation, the public sources of funding of operations and the mainly voluntary nature of EU S&R organizations.
Carbon Nano Materials Enabling High-Performance Lead Acid Batteries (CaNE-HiP-LA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Israel
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2015-03-01
End date: 2015-05-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The objective of this innovation project is to address the lead acid battery industry’s growing technology and market challenges through a Carbon-Nano Materials technology solution which dramatically enhances L.A. battery performance, without altering battery design or existing manufacturing processes, and at a nominal cost to the manufacturer. By doing so we will create a direct $2B / annum market opportunity across our value chain, substantially reduce the huge environmental footprint of the lead acid industry, advance European objectives in vehicle emissions reduction, and reinforce European leadership in nano-technology. Over the past 5 years, L.A. battery manufacturer Vulcan, together with its partners – France-HQ'd Carbon Nano Materials market leader Arkema, and Bar Ilan University’s nanotechnology and battery experts - have been developing a disruptive Carbon Nano Materials-based technology solution, branded VoltaNano, specifically targeted at the L.A. industry’s growing market challenges. VoltaNano-enhanced batteries now achieve over 100,000 ignition cycles on average based on a standard flooded battery platform, compared to the industry standard of ~30,000 cycles. Medium DoD cycle life is more than doubled. A novel method was invented to allow optimal dispersion within the lead acid matrix and enable seamless introduction into existing fabrication lines. Bill of materials was driven down to meet industry targets. VoltaNano is already integrated into Vulcan's own production line, and in-vehicle testing is in advanced stages. The objective of the feasibility study of phase 1, is to build a comprehensive business plan for the international dissemination of VoltaNano to lead acid manufacturers worldwide through a packaged license, service and materials-supply offering. Beyond this key objective, we will aim to achieve regulatory compliance, complete the in-vehicle testing program, and establish a first international pilot towards commercial launch in Phase 2.

Keywords: carbon nano materials,carbon nano tubes,multi walled carbon nano tubes,lead acid battery,enhanced lead acid battery,energy storage,automotive,transportation,passenger vehicles
Cross Assessment of Energy Certificates in Europe (crossCert)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Austria,Germany,Spain,Spain,Malta,Poland,Bulgaria,Greece,Croatia,Slovenia,United Kingdom,Denmark
Call: Next-generation of Energy Performance Assessment and Certification (H2020-LC-SC3-EE-2020-2, 2020)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 1997557.5
EU funding (EUR): 1997557.5
Participants: 12
Project status: SIGNED

Energy efficiency of buildings plays a paramount role in the European Commission (EC), who aims to achieve net-zero greenhouse gas emissions by 2050 in Europe through a socially-fair transition in a cost-efficient manner. The role of Energy Performance Certificates (EPCs) to boost building energy renovation is widely considered crucial in the literature because they are fundamental to provide better information to all the actors involved in the building renovation process. Besides, EPCs can act as a link between the different types of actions (institutional, financial, others) that will be needed to accomplish the building renovation goals. The crossCert project will create a product testing methodology for the new EPC approaches that will result in: improved accuracy and usability of the EPCs, people-centric designs, and increased homogeneity across Europe. The crossCert project is based on a bottom-up approach, with the following stages: (1) Cross-testing among energy authorities of current EPCs and the new approaches/concepts/initiatives, using more than 140 buildings in 10 European countries, and creating a public benchmarking repository of test cases; (2) Comparing and analysing the results between different approaches; (3) Elaboration of policy recommendations, which will include potential improvements on the accuracy, usability and harmonisation; (4) Engaging networks and alliances for analysis and (5) for outreach. Beyond accuracy, usability and harmonization, crossCert will use the cross-assessment exercise to conduct research and issue guidelines on: training and education of certified EPC issuers; EPC promotion and marketing; adapting EPCs investor needs; linking next-generation of EPCs to energy audits, logbooks and Building Renovation Passports; and EPCs and one-stop shops for building renovation.

Keywords: cross testing,test repository,accuracy,usability,people centric,homogeneity,convergence,bottom up,energy audits,building renovation passports,logbook,one stop shops
Migration in the early modern world: the Franciscans of the Custody of the Holy Land as a facilitator of the circulation of people in the Mediterranean (MIGMED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-09-01
End date: 2018-10-18
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Migration is a key socio-political issue in present-day Europe, however it is by no means a new phenomenon. Even though the importance of South-North (and vice versa) mobility on the development of our society has been addressed by historians, characteristics of this phenomenon have not yet been fully investigated nor have been the similarities between early modern’s mobility and our actual experience. Was migration in the early modern world a network driven phenomenon? What is the link between internal migration and long distance mobility? Leaving aside individual experience, how did migration influence the life of communities at large? This research project aims to answer to these questions and to deepen our understanding on migration in the Euro-Mediterranean region during the early modern period. In order to do so it investigates mobility between Palestinian parishes and from Palestine to Europe during the 17th and the 18th century focusing on the Custody of the Holy Land of Jerusalem. By complementing Islamic court records and Ottoman surveys with Franciscan sources and previously unused parish registers, it will shed new light on spatial mobility and will contribute to overcome the limits of current research on the topic. Methodologically, the proposal breaks new ground by combining micro-, meso- and macro-level analysis and conceptualizing the role of the Franciscan order as part of a migration network. The results of in-depth research on numbers, motives and experiences of individuals and groups moving in and around the Holy Land will help to advance the wider fields of migration, mission and parish studies in the Mediterranean.

Keywords: migration,mediterranean,ottoman empire,middle east,palestine,parishes,missionaries,religious conversions,cultural history,demography,franciscans,networks
INNOVATIVE ENGINEERING OF GROUND VEHICLES WITH INTEGRATED ACTIVE CHASSIS SYSTEMS (EVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: South Africa,Germany,Spain,Germany,Sweden,Belgium,France,France,Netherlands,United States,Netherlands,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 616500.0
EU funding (EUR): 571500.0
Participants: 15
Project status: CLOSED

Innovation technologies in ground vehicle engineering require strong interdisciplinary and intersectoral investigations with an international dimension. In this context the project EVE proposes sustainable approach based on intensive staff exchange that leads to collaborative research and training between universities and industrial organizations from Germany, Belgium, Spain, Sweden, The Netherlands, South Africa, and the USA. The project includes basic and applied research, development design, experimentations, networking, and dissemination and exploitation activities. The research objectives are focused on the development of (i) experimental tyre database that can be used in the design of new chassis control systems and subjected to inclusion into Horizon 2020 pilot on Open Research Data, (ii) advanced models of ground vehicles and automotive subsystems for real-time applications, and (iii) novel integrated chassis control methods. It will lead to development and improvement of innovative vehicle components such as (i) an integrated chassis controller targeting simultaneous improvements in safety, energy efficiency and driving comfort, (ii) new hardware subsystems for brakes, active suspension and tyre pressure control for on-road and off-road mobility, and (iii) remote network-distributed vehicle testing technology for integrated chassis systems. The project targets will be achieved with intensive networking measures covering (i) knowledge transfer and experience sharing between participants from academic and non-academic sectors and (ii) professional advancement of the consortium members through intersectoral and international collaboration and secondments. The project EVE is fully consistent with the targets of H2020-MSCA-RISE programme and will provide excellent opportunities for personal career development of staff and will lead to creation of a strong European and international research group to create new hi-tech ground vehicle systems.

Keywords: vehicle dynamics,automotive control systems,hardware in the loop,terramechanics
Microbiome Applications for Sustainable food systems through Technologies and EnteRprise (MASTER)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive agri-food sector for a safe and healthy diet
Action type: Innovation actions
Countries involved: Spain,Ireland,Italy,Italy,Germany,Ireland,Iceland,Austria,Austria,Spain,Germany,Ireland,Ireland,Norway,Belgium,Finland,Romania,France,France,France,France,France,Netherlands,Netherlands,United Kingdom,Denmark,United Kingdom,Canada
Call: Microbiome applications for sustainable food systems (H2020-SFS-2018-1, 2018)
Start date: 2019-01-02
End date: 2023-07-01
Duration (months): 54.0
Total project cost (EUR): 12136475.89
EU funding (EUR): 10950171.9
Participants: 31
Project status: SIGNED

Although microorganisms dominate almost every ecological niche in our planet, it has only been during the past 10-15 years that we have begun to gain insights into the composition and function of microbial communities (microbiomes) as a consequence of major advances in High Throughput DNA sequencing (HTS) technologies. These approaches have allowed a comprehensive analysis of microbiomes for the first time. Following initial curiosity-driven investigations of microbiomes using HTS technologies, the field has evolved to harness the insights provided, leading to the development of a new multi-billion euro industry focused on characterisation and modulation of microbiomes. The vast majority of this investment has been in the clinical space. In contrast, far less is known about microbiomes across complex food chains, making it difficult to harness food-chain microbiome data for the development of more sustainable food systems and to yield innovative products and applications. This is despite the evident importance of microbes throughout the food chain. MASTER will take a global approach to the development of concrete microbiome products, foods/feeds, services or processes with high commercial potential, which will benefit society through improving the quantity, quality and safety of food, across multiple food chains, to include marine, plant, soil, rumen, meat, brewing, vegetable waste, and fermented foods. This will be achieved through mining microbiome data relating to the food chain, developing big data management tools to identify inter-relations between microbiomes across food chains, and generating applications which promote sustainability, circularity and contribute to waste management and climate change mitigation. We will harness microbiome knowledge to significantly enhance the health and resilience of fish, plants, soil, animals and humans, improve professional skills and competencies, and support the creation of new jobs in the food sector and bioeconomy.

Keywords: microbiome,food science,food technology,food and drink processing,food quality and safety,sustainability,molecular biology,innovation