Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Lightening and Innovating transmission for improving Vehicle: Environmental Impacts (LIVE-I)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Italy,Italy,Poland,France
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-03-01
End date: 2024-02-29
Duration (months): 48.0
Total project cost (EUR): 2367270.36
EU funding (EUR): 2367270.36
Participants: 7
Project status: SIGNED

For several decades, vehicles have seen their weight increase to meet more demanding requirements of safety and comfort. At the present time, manufacturers need drastically reduce the energy consumption and greenhouse gas emissions without sacrificing any safety or comfort. Each vehicle element must be considered for weight reduction. In this regard, gear transmissions are a first choice candidate. They form a reliable, versatile, and efficient way to transfer power while representing a significant fraction of the vehicle’s mass. LIVE-I project main objective is to achieve breakthrough technological progress in the design of lightweight gear transmission and to build an innovative training network in order to educate early stage researchers in this hot topic. The technical objective of LIVE-I project is to demonstrate a significant weight reduction of transmission using advanced modeling tools and digital twins together with advanced materials and systems. This objective will be pursued along different ways, each starting with mass reduction and exploring ways to achieve compromises between weight, efficiency, noise and vibration impacts. The modeling will cope with physical complexities of the problem, connected to non-linearities, multi-scale character among others. The weight/NVH (Noise, Vibration, Harshness) and efficiency improvements of gear transmissions will be tackled by introducing new paradigms in the design of housing and components, using new meta-materials and meta-structures, studying the robustness of a given optimization with respect to real manufacturing conditions, developing smart concepts. Numerical simulations and experiments will be carried out to validate the solutions. In addition to the described technical approaches a tight integration of the individual ESRs into the overall research program is taken care of and a specific training plan devoted to their up to date education in gearboxes design and optimization is offered.

Keywords: greenhouse reductions,lightweight constructions,gear transmissions,noise and vibration harshness,efficiency,knowledge based design,robust design,digital twins,metamaterials,smart systems
Learning and Being in Sport: A Phenomenological Investigation (Learn2)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-03-01
End date: 2021-02-28
Duration (months): 24.0
Total project cost (EUR): 179325.6
EU funding (EUR): 179325.6
Participants: 1
Project status: CLOSED

Although sport is habitually promoted as an important context for positive youth development and learning, there is a lack of understanding of what learning in sport is and how it shapes and is shaped by the learner’s identity, values, and socio-cultural situatedness. Using an existential-phenomenological approach, we theorise and explore student-athletes’ learning experiences in sport, providing knowledge that is radically innovative and helps to validate experiential learning in sport. The study responds to European Union initiatives to safeguard the development of talented youth athletes and validation of informal and non-formal learning. Eighteen Finnish student-athletes (10 women) aged 18-19 will participate in hermeneutic interviews focused on clarifying meaning in their learning experiences in sport. Drawing on Structural Existential Analysis, we seek to uncover the essential – yet always situated – structures of athletes’ learning experiences. We also explore gender dimension of learning and sporting experiences. Based on the findings, we will propose a framework for further research and provide recommendations for policy and practice. The findings will be valuable for educational institutions and dual career service providers, as well as sport coaches and student-athletes to support athletes’ future employability and transition into the labour market. The existential-phenomenological perspective offers a novel methodological approach and our study involves a truly interdisciplinary research team (developmental and cultural psychology, existential philosophy, and phenomenological sociology). The project offers training for the experienced researcher in research and transferable skills as well as gender issues, and knowledge transfer through secondment, research visits, and seminars. The project provides the experienced researcher with the possibility to reinforce a position of professional maturity and become a research leader in the subject area.

Keywords: informal learning,youth sport,dual career in sport and education,career development and transitions
CalScreener® – an innovative device for Bacterial Analysis and Diagnostics through Growth and Energy-release in Real-time (BADGER)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Sweden
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-12-01
End date: 2020-07-31
Duration (months): 32.0
Total project cost (EUR): 3572567.5
EU funding (EUR): 3572567.5
Participants: 1
Project status: CLOSED

SymCel provides a novel cell-based assay tool for real-time cellular bioenergetics measurements. Our key product, the calScreenerTM, is the first multichannel calorimetric system specifically developed for cell-based assays, which to date has been sold to the pharmaceutical research segment only. Even though calorimetry is a highly advanced research tool, it is considered not suitable for broad scale uptake into daily clinical practice. Through the BADGER project we intend to break this paradigm by validating and commercializing an in vitro diagnostic tool, that is based on isothermal micro calorimetry, for determining MIC for antimicrobial susceptibility testing (AST) of hetero-resistant sepsis causing strains. By providing a tool for the easy, correct and timely diagnoses of hetero-resistant and extensively resistant infections, we will redefine the commercial application segment for calorimetry systems (from pure research settings -> near patient diagnostics) and take AST to a new level of accuracy and speed. The clinical importance of AST is increasing in line with the growing concerns over antimicrobial-resistance (AMR) and the misuse of antibiotics. Lack of a rapid, low-cost and readily available solution contributes to the inappropriate prescribing and overuse of antibiotics. Clinicians are in need of an accurate and rapid diagnostic test to increase antibiotic stewardship, introduce combination treatment for critically ill patients and help combat AMR. The calScreenerTM will meet the users’ needs by providing a reliable diagnostic tool with high speed, specificity, and sensitivity in a smartly designed and packaged device with the tools available to perform testing in a near-patient setting. In all, the Phase 2 project will lay the foundation to clinically validate the calScreenerTM which will improve diagnostic decisions, provide a higher service level for patients, combat AMR and allow for more personalized and cost-efficient approaches to healthcare.

Keywords: multichannel calorimetric system,alorimetry based clinical diagnostics,cell based assays,antimicrobial susceptibility testing,sepsis,antibiotic stewardship
The dynamics of sign language grammar: Morphology, language change, iconicity, and social structure in signing communities (SignMorph)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 2347968.75
EU funding (EUR): 2347968.75
Participants: 1
Project status: SIGNED

SignMorph aims to address two of the most fundamental questions in the language sciences: how much do the languages of the world resemble each other and how do they differ, and what factors account for both the cross-linguistic similarities and the differences? SignMorph will provide answers to these questions about the nature of human language through a focus on the sign languages of deaf communities. This project will also be the first to focus on key aspects of the grammar across three distinct subtypes of signing communities: (1) established macro-community sign languages used across an entire national deaf community, (2) established micro-community sign languages which are languages in smaller communities within a nation state, and (3) emerging sign languages which are sign languages that have only begun to emerge in the late 20th century. The driving research question is: sign languages are natural languages, but what kind of languages are they? SignMorph aims to better understand similarities and differences in the grammar of sign languages, and how these are shaped by language-internal and language-external factors. The factors to be investigated in the study include (1) the role of iconicity in mapping grammatical meanings onto form, (2) the relatively recent emergence of sign languages, and how their short history has impacted on the processes which create grammatical structure, and (3) the sociolinguistic structure of signing communities, particular the effect of the large proportion of child to child (rather than parent to child) transmission of sign languages, varying ages of first language acquisition, and variation in interaction individuals have with native signers through their social networks. The study of this distinctive combination of characteristics in sign languages means that this project will make a vital contribution to an understanding the human language capacity more generally.

Keywords: linguistics,sign languages,morphology,typology,sociolinguistics,psycholinguistics,language evolution
Study on Environmental and GenomeWide predictors of early structural brain Alterations in Young students (SEGWAY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-12-01
End date: 2022-05-31
Duration (months): 78.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Mounting evidence suggests that early life factors have an important impact on the occurrence of late-life neurological diseases. From a public health perspective this is of particular relevance for dementia, the prevalence of which is increasing drastically, with no available preventive treatment, and epidemiological data suggesting that pathological processes may begin many years before clinical diagnosis. MRI-defined structural brain phenotypes are powerful intermediate markers for dementia, and can already show measurable alterations in young and middle-aged adults. These include global and regional brain volumes, gray matter volume and cortical thickness, and markers of white matter integrity. The SEGWAY project aims to: (i) explore the heritability and genetic determinants of structural brain phenotypes in young adults in their early twenties participating in the i-Share study, the largest ongoing student cohort; (ii) take a lifetime perspective by examining the shared genetic contribution to structural brain alterations in young adulthood (i-Share) and late-life, among participants of a large French population-based study (3C-Dijon); (iii) explore the interaction between genetic variants and vascular risk factors with established impact on structural brain phenotypes, in both age groups; (iv) examine the clinical significance of genetic risk variants for structural brain alterations by testing their association with cognitive performance in young and older adults. Replication and of our findings will be sought in the multigenerational Framingham Heart Study and other independent samples. Identifying common biological mechanisms underlying both early and late-life structural brain changes would provide important information on the mechanisms and timecourse of brain aging throughout a lifetime and could be of major importance for identifying of molecular drug targets and characterizing high risk populations most likely to benefit from early interventions.

Keywords: brain volume,magnetic resonance imaging,alzheimer disease,dementia,genome wide association studies
The Global Dimension of the Libyan Crisis (GLIBAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-01
End date: 2025-02-28
Duration (months): 36.0
Total project cost (EUR): 269002.56
EU funding (EUR): 269002.56
Participants: 2
Project status: SIGNED

GLIBAL – The Global Dimension of the Libyan Crisis will provide a new reading of Libya’s ongoing war from a global perspective. Breaking with current interpretations that present the war as a result of historically self-inflicted and local problems, the project’s overall objective is to investigate how those processes that were central to the making of the US-led global order unfolded, shaped and were contested in a key country of the EU’s Southern Neighbourhood from 1969 to the present. It does so by capturing the manifold and interactive character that its people and places bear with those projects of financial and political control that consolidated at the global level from the end of WWII to the present day. By creating a better and timely understanding of the situation, the focus of the project will contribute to clarify the ways in which evolving global governance schemes—of which the EU is a major player—are connected to the formulation of policies to prevent conflict and tackle the issue of migration in the EU’s Southern Neighbourhood. More specifically, it aims to contribute to major areas of EU policy (European Neighbourhood Policy, Common Security and Defence Policy and EU Global Approach to Migration and Mobility). To accomplish this goal, GLIBAL will be undertaken in collaboration with two major academic institutions, Ca’ Foscari University of Venice (UNIVE) and Columbia University in the City of New York (CU), and under the guidance and supervision of the most apt and internationally established scholars, Profs Matteo Legrenzi and Timothy Mitchell. The expected results for the researcher’s career are: The consolidation of research outputs disseminated at the highest scientific level—and of communication activities fruitfully bridging research and positive societal impact issues—to underlie the achievement of a tenure-track academic position in his fields of specialization (Global and Middle East Studies).

Keywords: libya,global war,global order,middle east and north africa
Functionally Metalized Nanocellulose For Future Smart Materials (FUNMAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-01
End date: 2024-12-18
Duration (months): 33.0
Total project cost (EUR): 259399.17
EU funding (EUR): 259398.72
Participants: 2
Project status: SIGNED

Designing at the nanoscale is a promising and challenging strategy to innovate new building-block materials with improved properties and functionalities. This is a critical point to answer the increased demand of multifunctional materials. Nanocellulose is a functional structured nanomaterial engineered by nature long time before us. It maintains the optimal structural integrity in plant cell wall allowing plants to play their vital role in the ecosystem. Thanks to their high aspect ratio, high surface area and their 150 GPa, nanocellulose could be considered as a revolutionary renewable nano-building block material. Nanocellulose was principally investigated and used as bio-based filler in polymer nanocomposites. One of challenges in the developments of nanocellulose will be to make these naturally nano-structured objects functional with new properties allowing the design and engineering of smarter materials. Our proposal aims to bring nanocellulose to novel frontiers by functionalization of their large surface area and designing new innovative hybrids at the nanoscale. Main objectives of our project are: 1) setting up conditions for nanocellulose surface metallization. 2) Characterizing properties of these innovative nanohybrides and 3) Designing new functional materials based on metalized nanocellulose. The project is an opportunity to the fellow to restart his career in the exciting field of nanocellulose.

Keywords: nanocellulose,biocomposites,nano hybrid
Alzheimers Disease Apolipoprotein Pathology for Treatment Elucidation and Development - Sofia ref.: 115975 (ADAPTED)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Germany,Germany,Germany,Spain,Spain,Spain,Belgium,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: From ApoE biology to validated Alzheimer’s disease targets (H2020-JTI-IMI2-2015-05-two-stage, 2015)
Start date: 2016-10-01
End date: 2020-09-30
Duration (months): 48.0
Total project cost (EUR): 6796740.0
EU funding (EUR): 3510000.0
Participants: 14
Project status: CLOSED

APOEɛ4 has long been known as a risk factor of LOAD, yet the biological mechanisms through which it acts remain largely unknown and affect both the vasculature and the brain. This complexity and pleiotropic influence demands an integrated hypothesis-free approach to embark on a fundamental study of the gene, the phenotype and modulation by other risk factors. ADAPTED proposes to leverage extreme genotypes from consortium cohorts dating back more than 25 years to generate, and use existing, lines of human induced pluripotent stem cells (iPSC). These cells, with blood cells, will form the backbone of the research programme. We will differentiate them to the most relevant cells for APOE and AD studies and with gene editing create bespoke homozygote ɛ3 and ɛ2 cells for a highly focussed effort on APOE biology. A series of experiments including neuron-astrocyte and macrophage-endothelium co-culture and Organ on a Chip models combined with state-of-the-art omics including quantitative proteomics assays will generate data for rigorous integrated analysis to uncover new signalling pathways related to APOE. Lipid homeostasis, endocytosis, metabolism and immune systems pathways will be investigated in a broad approach. The findings are expected to lead to identification of new treatment approaches and blood based AD signatures with a temporal dimension from the earliest stages of risk identification and progression through MCI to AD. Testing and validation of biomarkers will be performed by examining their influence and predictive capacity in a longitudinal ADAPTED cohort harmonised using a combination of approaches for marker and diagnostic consistency. The impact of this work can be expected to include seminal new finding to illuminate the research path towards new diagnostics and therapies to attenuate the rising tide of suffering from AD. The vision is a follow on with clinical proof of concept validating utility of the results within two years of the end of ADAPTED.

Keywords: alzheimer s disease mild cognitive impairment apolipoprotein e genetic risk factors multiomics human induced pluripotent stem cells genome editing cellular models humanised animal models