Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Fluid Biomarkers for Neurodegenerative Dementias (FLUBIODEM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2422973.0
EU funding (EUR): 2422973.0
Participants: 1
Project status: SIGNED

Critical to our understanding of Alzheimer’s disease (AD) and other neurodegenerative dementias (NDDs), as well as to finding disease-modifying therapies, is the development of biomarkers for the underlying disease processes. To facilitate improved diagnostics and drug discovery, we have developed methods to measure markers of amyloid and tau pathology, central and peripheral nervous system injury, astrocytic and microglial activation, as well as neuroinflammation. Our most exciting advancement in this field so far is the development of phosphorylated tau assays sensitive enough to measure this protein in plasma to detect AD pathology in the brain and to allow for disease stratification and monitoring based on AD pathology. I now propose to develop new high-throughput biomarker tools that will enable the analysis of large cohort studies combining clinical, imaging, genetic and biomarker data to provide truly comprehensive molecular disease phenotypes that will inform interventions, drug discovery and translational research, clinical trial stratification, detection of risk and resilience factors (lifestyle-related, as well as genetic), and ultimately drive the quest towards clinically accessible personalised medicine in the NDD field. A large part of the research efforts will be focused on discovering new biomarkers for TDP-43 and α-synuclein pathologies, non-AD tau pathology, and lysosomal and synaptic dysfunction, through general and targeted proteomics on CSF samples, and through employing a novel cell type-biased tandem mass tag proteomics workflow to discover biomarkers related to neuronal, astrocytic, and microglial cells, and their different activation states. Promising CSF biomarkers will be examined in blood; biomarker candidates that are measurable in this matrix and correlate with CSF will be developed into sensitive and specific blood tests using cutting-edge technology, as we have previously done for Aβ40, Aβ42, T-tau, P-tau, NfL, and GFAp.

Keywords: biomarkers,dementia,alzheimer s disease,neurodegeneration,csf,plasma
Prevention, mitigation, management of infectious diseases on cruise ships and passenger ferries (HEALTHY SAILING)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Countries involved: Greece,Norway,Germany,Cyprus,Finland,Spain,Romania,Sweden,Italy,Croatia,United Kingdom,Switzerland
Call: Controlling infection on large passenger ships (HORIZON-CL5-2021-D6-01, 2021)
Start date: 2022-09-01
End date: 2026-02-28
Duration (months): 42.0
Total project cost (EUR): 3194560.79
EU funding (EUR): 3194560.79
Participants: 25
Project status: SIGNED

With vast experience, in-depth knowledge and established expertise in infectious disease prevention and control on passenger ships, HEALTHY SAILING consortium presents a comprehensive approach introducing innovative, multi-layered, risk and evidence-based, cost-effective tested measures for infectious diseases prevention, mitigation and management (PMM) differentiated for large ferries, cruise ships and expedition vessels. This approach covers: a) preparedness and response to known infectious diseases frequently occurring on passenger ships, diseases that have never occurred but for which preparedness is essential, diseases of unknown aetiology to ensure preparedness for future emerging pathogens/pandemics; b) the entire passenger/crew journey travelling from home to ship and returning, on-board, during shore-side visits; c) ship-board operations, shore-side company operations, port destinations and communities; d) a global perspective of project outputs towards communities and passenger shipping industry. Epidemiological studies, risk assessment, modelling for disease spread and aerosol/droplet dispersion and setting disease thresholds/alert levels will develop a scientific evidence-base and support production of evidence-informed guidelines on COVID-19 for ships/ports, passengers/crew vaccination, ventilation systems and expedition vessels’ medical operation needs. Development/testing of ship-specific syndromic surveillance, AI systems, decision support tools will contribute to early health threat detection on-board, risk-based proportionate responses, and healthy on-board environments. Toolkits for blended learning with hands-on training and technology induced behaviour change will further knowledge, awareness and compliance of all stakeholders. An integrated e-pass based on one-ID concept and toolkit predicting port response capacities will address port operation and community needs. A scientific international panel will promote a harmonized global approach.

Keywords: infectious disease epidemiology,preparedness,maritime health,cruise,ferry,expedition,ship,passenger,crew member
MetaScat: Metasurface-Advanced Interferometric Scattering for Fluorescence-Free Single Extracellular Vesicle Analysis (MetaScat)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 1
Project status: SIGNED

Recent studies have confirmed that diagnostics based on liquid biopsy with single extracellular vesicle analysis reach sufficient clinical accuracy. The analysis at the single particle level is critical due to their clinically relevant heterogeneity. However, the current standard, fluorescence-based imaging platforms, cannot be scaled and require complex sample preparation. To provide a label-free and scalable alternative to fluorescence-based microscopy for single extracellular vesicle analysis in liquid biopsy, this project will lead to the development of a metasurface-based integrated imaging platform that controls the image-contrast via nanophotonic resonances (MetaScat). The hypothesis is that MetaScat will enable the label-free detection of tiny refractive index changes induced by the binding of specific antibodies to the membranes of extracellular vesicles and extract information about their single-particle biomarker distributions with a low-cost, compact imaging device. Interferometric scattering microscopy (iScat) could provide the required sensitivity. However, conventional iScat relies on high numerical aperture objectives, inherently cannot be scaled, and is restricted to a small field of view. To overcome these limitations and enable the combination of high sensitivity and throughput with low complexity, dielectric metasurfaces will here enable a nanophotonic equivalent of numerical aperture filtering while also providing homogeneous signal enhancement for each particle. The extensive expertise of my host, NanoLab at the University of Trento (UNITN), in the integration of silicon photonic platforms and computation, will be critical for this project. In collaboration with the clinical environment I currently work in, MetaScat is designed to meet the need for scaling and implementing easy-to-use, low-cost technology for single extracellular vesicle analysis in clinical laboratories and enable a wider use for early disease detection.

Keywords: silicon photonics,nanophotonic devices,label free imaging,liquid biopsy,extracellular vesicles,guided mode resonances
Polymathy and Interdisciplinarity in Premodern Islamic Epistemic Cultures (KNOW)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2024-02-01
End date: 2029-01-31
Duration (months): 60.0
Total project cost (EUR): 1996396.25
EU funding (EUR): 1996396.0
Participants: 2
Project status: SIGNED

KNOW is the first comprehensive study of polymathy and interdisciplinarity in premodern Islam. The project sets out to write a history of knowledge that takes the interaction between disciplines as its primary subject. The project’s historical framework is the post-formative period, 1200-1800 CE, which saw the rise of new institutions of learning, the proliferation of libraries, the formation and integration of disciplines and curricular texts, and an increase in academic travel, facilitating interdisciplinary cooperation, competition and conflict. Despite its significance, our knowledge of this period remains rudimentary. The project promises to transform our understanding of the intellectual dynamics of this period by applying the lens of polymathy and interdisciplinarity. Previous scholarship has focused on intellectual products (i.e., doctrines and texts) and has tended to project our contemporary disciplinary divisions onto the premodern period (e.g., humanities v. sciences; religious v. secular). This project departs from these approaches by focusing on epistemic processes and practices rather than products and artefacts. To do so, the project tests three research hypotheses: (1) cultural and intellectual vibrancy of the premodern period is evident in the interaction between disciplines, (2) madrasa education and hospital culture produced an interdisciplinary space, (3) interdisciplinary practices created a common scholarly language. The project’s interdisciplinary methodology draws on the history of science, interdisciplinary studies and polymathy studies. The PI will be supported by an interdisciplinary team of three postdoctoral researchers covering, together, the intersections between philology, theology, exegesis, law, medicine, logic, algebra, and geometry in premodern Islamic epistemic cultures. Know will make significant contributions to interdisciplinarity and polymathy studies, as well as the emergent field of the history of knowledge.

Keywords: islamic intellectual history,arabic,qur an,interdisciplinarity,islamic theology,islamic law,islamic science
Development of a photoelectrochemical device for Ammonia production (DEMONIA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-08-01
End date: 2024-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The growing world population is pressing on an increasing global food and energy demand, and simultaneously contributing to an unceasing rise in carbon dioxide emissions. In this context, finding inexpensive and fossil-free pathways to supply energy and food has become one of the most critical challenges of this century. On this scenario, ammonia (NH3) is envisaged as a zero-carbon fertiliser, fuel and energy store, with a potential key role in the transition towards a low-carbon economy. DEMONIA is a high gain proposal to address the aforementioned challenges, by means of the development of a scalable and environmentally friendly photoelectrocatalytic device for the production of solar ammonia. This key platform molecule will be produced using a new generation of hybrid heterostructures based on Conjugated Porous Polymers (CPPs), which have not been studied for NH3 production until now. These materials are expected to outperform conventional photoelectrodes, leading to higher N2 conversion to ammonia. DEMONIA project will evaluate the feasibility of this novel photoelectrochemical solar ammonia approach, with the aim of accelerating the development of this technology for a near-future access to the market. The success of this proof of concept will have important commercial implications in a wide range of energetic and environmental research areas (energy sector, agriculture, transportation, chemical and pharmaceutical industry). Besides, the strong inter- and multidisciplinary approach (chemical, physical, engineering and materials science) of this proposal is expected to impact on several fields, from fundamental research to applied investigations concerning renewable energy production. The transfer knowledge plan will be a vendor IP strategy based on the information obtained by previous contacts with Industry/manufacturer holders with interest on this innovative technology. It implies Effectiveness, Patent, Transfer of Knowledge, and Dissemination.
Climate Models and Climate Scientific Understanding (CMCSU)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

What exactly is the epistemic goal of constructing climate models? Can these models help us in our endeavour to understand Earth’s climate system and our role in climate change? This is a very important question that hasn’t yet received the attention it deserves in the recent philosophy of climate science. My overall research objective in this project is to address this important lacuna. I plan to do this by developing an account of climate scientific understanding and the means by which we can achieve understanding in climate science. The method I will use originates with Carnap and has recently gained a great deal of popularity, i.e. conceptual engineering. I will achieve this objective by combining my previous expertise on the topic of understanding with scientific models and the role of mathematics in scientific understanding with the new skills and competencies gained through advanced training, under the guidance of a highly qualified supervisor, Prof. Stephan Hartmann, a leading expert on scientific models and their role in science. Conducting this project at the Munich Center for Mathematical Philosophy (LMU) will considerably improve my research and help me make significant contributions to the current discussion in the philosophy of climate science. This will establish me as an independent research leader in Europe and, therefore, help me secure a permanent academic position. The results of this project can have a wide-ranging impact on the philosophy of science and neighbouring philosophical and scientific disciplines. For instance, it can contribute to a better understanding of the practice of climate science, it can generate a new context for forging interdisciplinary relations between philosophers and climate scientists, and (suitably modified) it can be used in a general strategy to help the general public better understand and trust climate science. My project fits with the 13th goal set out in the UN 2030 Agenda on Sustainable Development

Keywords: philosophy of climate science general philosophy of science scientific understanding scientific models model understanding scientific explanation model explanation climate models
WILA19-91, WOMEN’S INTELLECTUAL AND ARTISTIC LABOR 1919-1991 (WILA19-91)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 1
Project status: SIGNED

WILA19-91 main aim is to to bridge the gap between intellectual history and labor history, and through this methodological innovation not only highlight the disparity between intellectual labor and intellectual achievements, but also challenge historiography's perception of the latter. While intellectual history predominantly focuses on artistic and intellectual achievements, it often fails to question the underlying conditions that made such achievements possible. Consequently, many marginalized groups have been excluded from the canon, as they did not have the necessary working conditions to consistently produce intellectual or artistic labor. The WILA19-91 project focuses specifically on women's intellectual labor from 1919 to 1991, utilizing Yugoslavia as a transnational laboratory space to observe the dynamics of intellectual and artistic labor across different time periods, generations, social classes, nationalities, and ethnicities. The project's outcomes will contribute to establishing new norms for reevaluating artistic and intellectual achievements, ultimately broadening and decolonizing the canon. The project examines work conditions, considering the power structures associated with intellectual authorities, social prejudices, intimate beliefs, and invisible social agreements at various times. To achieve this, it explores the intersection of intellectual, labor, and gender history. By drawing on a diverse range of sources in different languages (Slovene, Croatian, Serbian, German) and amplifying the voices of women from ethnic and sexual minorities, this project will investigate working conditions, attitudes towards work, legislative changes, family dynamics, public reception, financial compensation and care work, in order to understand the division between intellectual work (as labor) and being an intellectual (as a status).

Keywords: intellectual work,artistic work,valuation of intellectual and artistic work,gender,yugoslavia,labor centric perspective
Wireless Networks at Optical Speed with Deterministic Performance (TeraWireless)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece,France,Italy,Germany,Spain,United Kingdom,Sweden
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-03-01
End date: 2029-02-28
Duration (months): 48.0
Total project cost (EUR): 3809959.2
EU funding (EUR): 3454941.6
Participants: 11
Project status: SIGNED

Future networks will support several applications that require extending fiber-optic quality of experience to wireless links. This means connectivity at extremely high data rates with deterministic performance (guaranteed requirements in terms of reliability and time response). Virtual avatar presence, traffic control, autonomous driving, remote health monitoring, cyber physical systems for intelligent transportation, industrial automation are only a few examples of anticipated use cases. Owing to the large amount of available bandwidth, the European Telecommunications Standards Institute has identified terahertz (THz) as a key technology for future wireless networks. TeraWireless is the first EU training-through-research industrial doctoral network of doctoral candidates and senior supervisors fully committed to lay the theoretical, algorithmic, and architectural foundations for enabling THz systems at optical speed with deterministic performance. TeraWireless will 1) put forth the innovative ultra-MIMO (multiple-input multiple-output) technology for increasing the data rate and link reliability through spatial multiplexing and superdirective beamforming, and will pioneer the development of electromagnetic and communication models for evaluating its performance in low-scattering THz channels, where multipath propagation cannot be exploited, by integrating sensing, localization, communication capabilities; 2) leverage the emerging concept of semantic and goal-oriented communications by folding message semantics and goals of communication within communication layers; 3) develop innovative physics-based ML solutions for energy-efficient, robust, reliable, and explainable-by-design implementations; 4) make available to the research community the EU’s and world’s first open-access and open-source simulation environment - integrating ray tracing, link-level, and system-level features - for evaluating and optimizing THz large-scale deterministic networks at optical speed.

Keywords: 6g wireless networks,terahertz communications,multiple input multiple output systems,semantic communications,rule based machine learning
Creating Suspects. Security Politics and Colonial Rule in the Spanish Empire (SUSPICIO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 1999706.0
EU funding (EUR): 1999706.0
Participants: 2
Project status: SIGNED

SUSPICIO proposes an entirely new hypothesis in the field of modern history as well as in Hispanic studies: that security became a key concept of governance in the late Spanish Empire (ca.1770–1820). This phenomenon began in the last quarter of 18th century when Spain felt the threat of losing its American colonies through external events that questioned the colonial rule, including US independ-ence and the influence of the French revolution. The perception of threat and the Spanish government’s distrust of their own population in America gave rise to extensive security regulations and measures in order to protect the colonial order. With my extensive expertise in both archive research and Hispanic studies, SUSPICIO will, for the first time, study thus far neglected sources of political crime. The novel approach to these sources will ana-lyse how the colonial administration identified and judged those individuals who were perceived to be a threat to the order, i.e., who were categorised as ‘suspects’. There was no longer the requirement for a rebellious act to already have occurred in order to make an individual an enemy of the state, but ra-ther the mere suspicion that a person would perhaps – in the future – act against the state. SUSPICIO will study to what extent the creation and persecution of ‘suspects’ polarised the people so that, rather than preserving the colonial rule, it had a debilitating effect. By regarding the ambivalence and counterproductive effects of security politics, the project promises a new interpretation of the dis-solution of the Spanish Empire. Its case may serve as an example, even for today, of how supra-national political entities can collapse under the pressure of security concerns, even though these secu-rity measures were meant to preserve them.

Keywords: security,surveillance,categorization