Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Infrared nanospectroscopy to understand and combat Alzheimer's disease (nanoIR4AD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2026-06-30
Duration (months): 34.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

Neurodegenerative diseases are a ticking time-bomb for health care systems because they are care-intensive and will soon become much more wide-spread due to increased life expectancy. Their most common form is Alzheimer's disease (AD), in which the amyloid-ß (Aß) peptide aggregates to amyloid fibers that accumulate in plaques in the human brain. We will study unresolved key aspects of AD in order to understand and eventually combat the disease. The objectives are: 1. To map the biochemical composition of plaques with unprecedented spatial resolution in order to understand the role of lipids in plaque organization and development - possibly leading to a biochemistry-based classification of these brain lesions, 2. To characterize co–aggregates of Aß with other amyloidogenic polypeptides, which may link different diseases and improve diagnosis, 3. To improve anti-amyloid peptides for a possible new AD treatment by characterizing and optimizing their interaction with Aß, and 4. To establish isotope-edited nanoscale infrared (IR) imaging as a versatile tool to characterize chemically similar components of mixtures. We will exploit the advantages of novel approaches in IR spectroscopy to move the field forward in areas that are difficult for more common methods. IR nanospectroscopy with 20 nm spatial resolution will be used throughout and will be combined for the Aß studies with isotope-edition and with Fourier transform IR spectroscopy. The supervisor is a well-know expert in biological IR spectroscopy and has recently established all approaches in his work. I, as the researcher, will be trained in advanced IR spectroscopy as well as in transferable skills, incl. leadership, and in pedagogics. The expertise in IR nanospectroscopy will particularly promote my career because the technique is about to revolutionize chemical imaging and has many applications in basic and applied science. For the same reason, also the EU will benefit from additional experts in this technique.

Keywords: alzheimer s disease,infrared spectroscopy,amyloid,plaques,scattering type scanning near field optical microscopy s snom,alpha synuclein,islet amyloid polypeptide,atomic force microscopy
Multicompartment combinatory pre-clinical model for melanoma drug screening (SkinModelOma)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 172618.56
EU funding (EUR): 172618.56
Participants: 1
Project status: CLOSED

One of the biggest limitations in developing new treatments for cutaneous melanoma relies on overcoming the inefficient screening, often to animal models, which greatly differ from humans. Also, the 3Rs principle limits the number of therapeutics that actually reach the in vivo evaluation of product/drug development or discovery. Thus, there is a high demand for novel pre-clinical platforms, as alternative models to the use of animals, that can screening new treatments. I propose the establishment of a multicompartmental melanoma graft model based on an ex vivo skin tissue grafted with a multicellular spheroid composed by melanoma cells, keratinocytes and monocytes. The ex vivo melanoma graft model, called SkinModelOma, will be a major breakthrough in the study of melanoma tumor growth and on the effectiveness of new therapies in different types of skin and considering gender and age. To the best of my knowledge, this will be the first ex vivo melanoma graft model, and the first model for skin cancer considering age, gender and skin type as important parameters in novel therapies screening for skin cancer. This proposal includes 3 scientific work packages related to 3 objectives and includes transversal work packages related to my training and improviment as a researcher. The objectives are based in the development and standardization of multicellular spheroid, their graft in the human skin and the validation of this model as a screening platform. I believed that the SkinModelOma proposed here will contribute to significant scientific advances in cutaneous melanoma patients’ management and also to great international recognition that will enable other researchers to benefit from a novel pre-clinical tool.

Keywords: tissue culture,3d spheroids,screening platforms,skin cancer,nanomedicines
The first high-performance, low-cost flat panel antenna terminal at Ka band to unlock the full potential of satellite-based broadband communications (Greenerwave)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-12-01
End date: 2025-11-30
Duration (months): 24.0
Total project cost (EUR): 3560500.0
EU funding (EUR): 2492350.0
Participants: 1
Project status: SIGNED

Greenerwave is developing a new type of flat panel antenna for the Ka band using proprietary beamforming technologies that shift the complexity from HW to SW, achieving low production costs and low energy consumption (at least x5 reduction compared to state-of-the-art in both cases), and thus solving the main bottleneck for mass adoption of LEO/MEO mega-constellations. The solution is seen as a key enabler for the EU-based planned IRISS multi-orbit constellation, a strategic asset for Europe. Greenerwave has already received interest from 20+ European satellite operators (e.g. Eutelsat, Intelsat, SES/O3b), suggesting high market demand. Based on a B2B model and the establishment of solid partnerships, we forecast to achieve sales of 18.1k Ka antennas and licensing of 900k units in 2030, representing €152 million revenue. Our vision is to achieve mass-market adoption and become a global leading provider of flat panel antennas for user terminals in the consumer broadband market.

Keywords: waves physics,panel flat antennas,electronically steerable antennas,high frequency communication technologies,consumer broadband,on the move communications,5g
Defect-Tolerant Materials for Energy (MATERIALISE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499995.0
EU funding (EUR): 1499995.0
Participants: 1
Project status: SIGNED

Defects are at the heart of modern electronic materials. Our ability to precisely design and control defects has advanced computing, energy generation, catalysis, and hundreds of other applications contributing over €4 trillion to the global economy. It is therefore surprising that our capacity to a priori rationalise the presence and behaviour of defects is severely limited. While computational tools can now predict defect properties with high accuracy, they are constrained in their widescale application due to the enormous computational costs involved. This presents a major bottleneck in the design, optimisation, and adoption of next-generation electronics, impacting our ability to create new renewable energy devices for the net zero target. MATERIALISE will discover new energy materials at the forefront of the EU’s innovation strategy including solar absorbers, thermoelectrics, and transparent conductors. This will be achieved by developing and applying a novel method to capture the impact of defects in semiconductors rapidly and accurately. Based on proof-of-principle work where I demonstrated state-of-the-art machine learning approaches can accelerate and circumvent the use of costly computational defect calculations, MATERIALISE, will enable a 4-5 order-of-magnitude increase in the number of materials that can be accurately screened for energy applications. Crucially, I will identify defect design principles that can yield optimisations across the semiconductor sector more broadly. MATERIALISE will adopt an integrated approach to materials discovery, extending the boundaries of what is possible in computational design through electronic-structure calculations of bulk, surface, interfaces, transport, and synthesisability. My international network of collaborators will validate and build devices for the most promising candidates. This new approach to designing defects in materials will establish my group at the forefront of computational materials science.

Keywords: defects,doping,machine learning,density functional theory,energy materials,high throughput
Personalised Medicine, the evolution of healthcare for improving people’s lives (PM4Future)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Other health destinations
Action type: Coordination and support actions
Countries involved: Spain
Call: Presidency event - Spain. Genomics-based health strategies: towards personalised and precision medicine (HORIZON-HLTH-2023-PSPA-10-IBA, 2023)
Start date: 2023-04-01
End date: 2023-12-31
Duration (months): 9.0
Total project cost (EUR): 341836.25
EU funding (EUR): 300000.0
Participants: 1
Project status: CLOSED

The project PM4Future aims at organising a Conference on Personalised Medicine with the overarching objective of identifying challenges and opportunities for the implementation of personalised medicine in the healthcare as well as gaps on research and funding. The event, organised by the Spanish Foundation for Science and Technology (FECYT), on behalf of the Spanish Ministry of Science and Innovation (MCIN) and with collaboration of the Institute of Health Carlos III (ISCIII), the Centre for the Development of Technology and Innovation (CDTI), will be held on October the 4th and 5th 2023 in Valencia. The agenda will focus on three main axes: 1) Prevention, diagnostics and treatment of diseases through a personalised approach; 2) Tools for Personalised Medicine: the role of federated transnational research infrastructures in the research and development of PM; and 3) International cooperation as an element to promote the development of Personalised medicine in African and Latin American regions.

Keywords: personalised medicine,conference,spanish presidency of eu,international cooperation,
A robotic platform for rapid optimization and scale up of photocatalytic transformations (RoboChem)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-12-01
End date: 2027-05-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

In the ERC Consolidator Grant FlowHAT, we developed RoboChem, a fully autonomous robotic platform capable of optimizing photocatalytic reactions with minimal human intervention. Despite its success, several key challenges emerged that limit its full potential, including overlooked reaction parameters in literature, the absence of a seamless workflow between high-throughput experimentation (HTE) and autonomous optimization, and inherent biases in published reaction datasets. The ERC Proof of Concept (PoC) RoboChem project aims to address these limitations by integrating RoboChem with HTE technology, creating a hybrid workflow that enhances efficiency, reproducibility, and scalability in reaction optimization. HTE will provide rapid, broad screening of reaction parameters, systematically identifying key factors affecting yield and selectivity. RoboChem will then refine these parameters, delivering precise optimization while reducing material waste and development time from months to days. This dual approach mirrors traditional chemical discovery but significantly accelerates the process, ensuring robustness in both academic and industrial settings. By integrating HTE-driven screening with AI-powered robotic optimization, this project will establish a data-driven reaction optimization framework that improves predictive modeling and enhances experimental reproducibility. Through validation in industrially relevant contexts, we seek to demonstrate RoboChem’s transformative potential and pave the way for a spin-off company dedicated to advancing automation in synthetic chemistry.
Inclusive History of East-Central Europe: Mid-19th Century to Present (INHIST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Czechia
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 2499900.0
EU funding (EUR): 2499900.0
Participants: 1
Project status: SIGNED

INHIST is based on the premise that current efforts to build an inclusive society urgently require education that offers an inclusive and multivocal interpretation of our past. Official interpretations of modern European history, especially of East-Central European (ECE) states, are still dominated by a narrow vision of the one-nation state. INHIST offers an alternative in the form of an inclusive history of ECE, in which history from the mid-19th century to present is analyzed from the perspective of three marginalized and internally diverse communities: Roma and Sinti, Jews, and people with disabilities. The project introduces the concept of ‘polyphonic inclusivity,’ inspired by Mikhail Bakhtin, in which intertwined histories of different historical actors are presented without privileging anyone’s voice over another. Geographically, the project focuses on Poland, Ukraine, Czechia, Slovakia, and Hungary. INHIST primarily traces individual and collective efforts at emancipation that show the diverse agency of Roma, Jews, and disabled people in co-shaping the histories of ECE. Methodologically, INHIST pursues an intersectional approach across these three communities and with an emphasis on gender and class, while developing a historical view of everyday life from below and from geographical periphery. Through extensive archival research, INHIST examines previously neglected sources produced by Romani, Jewish, and disabled people, including less-accessible sources in languages including Romanes and Yiddish. The team includes specialists in Romani, Jewish, and disability histories who speak at least ten languages and have also expert knowledge on the history of the individual countries in our focus. INHIST is thus a groundbreaking attempt to radically reinterpret the history of ECE through the paradigm of polyphonic inclusivity that overcomes the ‘methodological nationalism’ and ethnic hierarchies that have so far dominated historiographic research.

Keywords: roma and sinti jews disability studies east central europe emancipation
Deciphering rhinovirus-mediated macrophages impairment through the establishment of human induced pluripotent stem cells-derived macrophages (MacroRhino)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

A growing body of evidence suggest that viruses can modulate myeloid cells responses leading to long term impairment of monocytes/macrophages phenotypes. Whereas for virus directly infecting macrophages, the long-term effects on these cells function and phenotype have been extensively studied, for virus infecting other cell types, the effects on macrophages have been overlooked. Yet, recent data suggest that virus-mediated modulation of macrophages can even occurred when the virus do not replicate in these cells. Indeed, viruses have broader ways to modulate the innate immune responses than the one identified in permissive cells. Understanding the mechanisms of action employed by viruses to modulate macrophages responses could not only provide possible targets to eliminate the infection, but also offer therapeutic options to prevent/avoid virus-associated pathogenesis. Human rhinovirus (HRV) impairs macrophages’ responses upon secondary challenge with bacteria. The host laboratory identified arpin as a critical factor targeted by HRV to alter the phagocytic activity of macrophages and showed that HRV16-treated macrophages present a “paralysed” phenotype in terms of cytokine secretion. The precise mechanisms governing the reprogramming of the macrophages are however not fully elucidated. Furthermore, it is still unclear whether HRV needs to replicate within macrophages to reprogram their phenotype and functions. Therefore, my objectives are to decipher (i) if HRV can replicate in alveolar macrophages and (ii) what are the HRV-mediated mechanisms leading to impaired macrophages’ functions. Moreover, the models employed to study macrophages present advantages but do not recapitulate organ physiology, which plays a key role on the resident macrophage phenotype. Therefore, I will develop a model of human lung alveolar macrophage-like cell (LAML) derived from induced pluripotent stem cells (h-iPSC) to answer the above-mentioned objectives.

Keywords: macrophages phagocytosis innate immunity host pathogen interaction copd
Advancing Energy Conversion Technologies: High-Frequency Magnetics in Modern Power Electronics (MAGNIFY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium,Finland,Slovakia,Greece,Italy,Poland,Spain,France,Switzerland
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 4852607.25
EU funding (EUR): 4260106.44
Participants: 15
Project status: SIGNED

Power electronics constitutes a core enabling technology in the energy transition decarbonizing our society. It is omnipresent in energy conversion applications linked to electrification and decentralization, such as renewable energy, storage integration, AC and DC microgrids, and electromobility. Wideband gap semiconductor technologies have been key for its rapid progress, and equally crucial are the high-frequency magnetic components, i.e. inductors and transformers. However, there is a lack of engineers with a comprehensive understanding of the whole chain and their intrinsic multiphysical and multiscale interactions: magnetic materials, magnetic component models, power electronic circuits and converters. MAGNIFY addresses this urgent need by focusing on three research objectives: 1) tailoring and characterising magnetic materials; 2) developping new efficient multiphysical and multiscale models of magnetic materials and components, integrating these models in the power electronic circuits; 3) aiming at a holistic system-level design of energy converters in several applications. MAGNIFY will exploit the expertise of the consortium to achieve these objectives and equipe 15 research fellows with the relevant skills and innovative tools to contribute to the development of energy- and cost-efficient power electronics to enable sustainable electrification. While becoming experts in the individual carefully chosen research topics, the participating companies will benefit from the generated magnetic material database, the more efficient and accurate models, the software tools, and the new design methodology. In addition, the research fellows will be exposed to different working environments owing to the involvement of five companies in the research and training program. This synergy between research output and the unique engineering profiles of the trained research fellows will increase the competitive advantage of the EU in the field of energy conversion technologies.