Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Bridging the gap: an evolutionary genomics approach to illuminate the prokaryote-to-eukaryote transition. (Gap2bridge)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

Eukarya – one of the three Domains of Life along with Archaea and Bacteria (i.e. prokaryotes) – include all complex multicellular life forms, as well as a colossal diversity of unicellular microorganisms. At the cellular level, the gap between prokaryotes and eukaryotes is immense, with the latter cell types displaying a large number of complex subcellular organelles and molecular systems. The evolutionary origin of these unique features, and thus of the eukaryotic cell itself, remains one of the most fascinating enigmas in modern biology. Although many eukaryotic-signature proteins (ESPs) are known to trace back to the last eukaryotic common ancestor, their deeper evolutionary origins remain unclear. The major goal of the current proposal is to illuminate the prokaryote to eukaryote transition by elucidating the origin and subsequent evolution of ESPs, as well as their order of emergence. We will focus on the ESPs of archaeal origin with an emphasis on the specific contribution of the newly discovered Lokiarchaeota lineages to the origin of the eukaryotic cell. In addition, we will aim to determine the placement the eukaryote lineage within the tree of Life and infer the age of the “first eukaryote”. Finally, we will use a novel phylogenomic approach to infer the gene content of the archaeal ancestors of eukaryotes by mapping the evolution of ESPs along the tree of Life. For this purpose, we will analyse entirely novel genomic data from several uncultivated Lokiarchaeota lineages, as well as novel sequence data from deep-branching key eukaryotes. This project will integrate approaches from distinct disciplines within life sciences and computational sciences (including molecular evolution, genomics/metagenomics and cell biology), with a strong emphasis on phylogenomics. Altogether, the innovative nature of this work combined with state-of-the-art methods and novel key genome data will allow to gain unprecedented insights in the origin and early evolution of Eukarya.

Keywords: eukaryotes,eukarya,archaea,prokaryotes,phylogenetics,phylogenomics,comparative genomics,lokiarchaeota,early evolution,ancestral genome reconstruction,tree of life,microbial genomics,genome
Integration of Novel Stack Components for Performance, Improved Durability and Lower Cost (INSPIRE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Germany,Germany,Germany,Germany,Finland,France,France,United Kingdom
Call: Low cost and durable PEMFCs for transport applications (H2020-JTI-FCH-2015-1, 2015)
Start date: 2016-05-01
End date: 2019-10-31
Duration (months): 42.0
Total project cost (EUR): 6878070.01
EU funding (EUR): 6877869.75
Participants: 12
Project status: CLOSED

The objective is to develop and integrate the most advanced critical PEMFC stack components, many from recent FCH JU programmes, into an automotive stack showing BOL performance of 1.5 W/cm2 at 0.6V, <10% power degradation after 6,000 hours, with a technical and economic assessment showing a cost of less than €50/kW at a 50,000 annual production scale. This will be achieved by leading industrial and academic partners with expertise in the design and manufacture of PEMFC stacks, their components and materials. They will select and build on components which can achieve key target metrics, e.g. catalyst materials showing mass activities of 0.44 A/mg Pt. There will be focus on integration of the key components and optimisation of the interfaces regarding the electrochemistry, mass and heat transport, and mechanical interactions. Several iterations of an advanced stack design will be evaluated. Work is organised to optimise the flow of development, which begins with catalysts being advanced and down-selected, scaled then fed into the design and development of catalyst layers, integration with membranes and the demonstration of CCM performance. The CCMs feed into stack component development where they will be integrated with GDLs to form MEAs; and where bipolar plates will be designed and developed and supplied with the MEAs for iterative stack design, assembly and testing. All mandatory and optional objectives of the FCH 2 JU Work Plan are addressed. Performance and durability are evaluated from small single cell to stack level using standardised test protocols. Degradation is addressed by stability testing, structural visualisation and modelling. Interfaces and specification alignment is an important focus, being integrated with the evaluation of new architectures and synthesis methods and informing balance of plant component specifications. Dismantling and recycling for the recovery and re-use of all critical MEA components is included in the costing evaluation.

Keywords: catalyst,catalyst layer,membrane,seals,bipolar plate,stack,component integration,performance,stability,degradation,durability,costing
Open access virtual testing protocols for enhanced road users safety (VIRTUAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Austria,Slovenia,Sweden,Switzerland,Norway,Sweden,France,France,Netherlands,Netherlands
Call: Protection of all road users in crashes (H2020-MG-2017-Two-Stages, 2017)
Start date: 2018-06-01
End date: 2022-11-30
Duration (months): 54.0
Total project cost (EUR): 6997943.75
EU funding (EUR): 6997843.75
Participants: 17
Project status: CLOSED

The objective of VIRTUAL is to improve the safety of road users by providing procedures and open access tools to assess the benefit of novel safety systems. The goal is to establish a European based global hub for Open Source Virtual Testing (OpenVT) and to demonstrate its success in traffic safety. Open Source Human Body Models of both men and women will be made available in a format that is scalable to represent different ages and sizes of car occupants, vulnerable road users, and users of public transport. VIRTUAL will develop computationally efficient, robust crash simulation tools and standardised protocols for impact scenarios not yet considered in regulations or consumer testing. It will cover enhanced integrated safety for pedestrians, cyclists, occupants of (automated) vehicles and public transport. An OpenVT platform will be established to provide stakeholders with all models, tools and protocols for virtual testing (VT); the platform will continue to be available after this project has ended. These new resources will allow the European automotive sector and transport providers to produce better performing safety systems that will reduce road casualties. VIRTUAL will demonstrate how current road safety assessments can be complemented and improved by VT giving full credit to vehicle manufacturers and transport providers for their efforts in providing best real-world vehicle safety. VIRTUAL will close the gap between VT and standardised vehicle safety assessments by providing models of the humans (validated for safety assessment) and the protocols and criteria needed to identify the foremost road user protection beyond the scope of physical testing and provide a method for cost-benefit analysis of novel systems. VT will reduce the number of physical tests needed while addressing a greater variety of accident scenarios and road users, actively promoting safety innovations reducing the number of injuries and fatalities providing safer road transport in Europe.

Keywords: virtual testing,open source human body model,average female,vehicle safety,child,pedestrian and cyclist safety,public transport safety,consumer testing,injury prevention,cost benefit
Development of an in silico model for prediction of in vivo human bone fracture healing using micro-finite element analysis (HealinguFE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Current knowledge of fracture healing is based on experimental animal studies of diaphyseal bone, despite 20% of fractures occurring in the metaphysis of the distal forearm. Moreover, current fracture healing assessment tools lack the resolution to identify and isolate the initial fracture site in cases involving a crushing fracture. The objectives of this project are to (1) develop a micro-finite element (μFE) model for fracture site identification, (2) develop an in silico model for human bone fracture healing capable of tracking local microstructural changes, and (3) test the predictive power of the in silico model using clinical data. μFE models will be generated from high-resolution peripheral computed tomography (HRpQCT) data of the distal radius from wrist fracture patients. The μFE models will be generated from HRpQCT data collected at the early stages of fracture healing and compared to remodelling maps in order to determine if μFE models can be used to isolate the site of the initial fracture. Adaptations will be made to an existing in silico model based on the findings of the μFE analysis. The resulting in silico model will be applied to clinical HRpQCT data to predict endpoint microstructural changes as well as patterns in fracture healing and remodelling. The predictive power of this in silico model will be determined by comparing the simulation results to observed behavior in vivo. The proposed project merges recent advances in bone mechanobiology, μFE simulations, and medical imaging to develop novel image analysis and registration methods as well as a tool for predicting if, when, and where fracture healing will occur. The proposed work will provide insights into the local behavior of trabecular bone fracture healing and help the fellow achieve professional maturity. Further, the in silico model has the potential to change the landscape of fracture healing research, particularly in areas of preclinical testing and personalized medicine.

Keywords: fracture site identification,bone healing,mechanobiology,micro finite element analysis,in silico modeling
Emerging Printed Electronics Research Infrastructure (EMERGE) (EMERGE)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Austria,Germany,Spain,Greece,Poland,Greece,Sweden,Portugal
Call: Integrating Activities for Starting Communities (H2020-INFRAIA-2020-1, 2020)
Start date: 2021-07-01
End date: 2025-06-30
Duration (months): 48.0
Total project cost (EUR): 6177816.0
EU funding (EUR): 6177816.0
Participants: 11
Project status: SIGNED

The aim of EMERGE is to establish the first integrated, distributed research infrastructure supporting comprehensive user projects for multi-and-trans-disciplinary research on sustainable flexible large-area printed electronics and photonics (FLAPEP) value chain, going from materials formulation to design and architecture of processes, devices and systems, backup by characterization, test modelling and simulation tools, through a coordinated open-access for RTOs, industry and SMEs to complementary facilities. This is a route for creating added value and road mapping the introduction of new, recyclable electronics products at “Half-the-time/ Half-the-cost” to establish a sustainable prosperity, as required by today’s science and technology challenges and ESFRI landscape analysis. The overall objective of EMERGE is to provide access for users working with materials such as paper, textiles or biocompatible polymers to small-footprint FLAPEP technologies which enables emerging devices by using industrially compatible hybrid printing processes (roll-to-roll (R2R), functional 3D printing, etc.) accompanied with in-line inspection tools and automatic systems for high throughput inks determination, both driven by a novel Knowledge repository powered by Artificial Intelligence (AI) methods. At least 1400 users will be involved in the project through cross-border experiments, while creating at least 4 Symbiotic Clusters transregional connected, 4 Innovation gateway Hubs focusing on technology brokerage and 1 transversal hub valuing the results of the prototypes within a market approach. EMERGE will focus intensively on networking among partners and stakeholders through advocacy and dissemination, sharing data and information management and exploitation to ensure a long lasting, sustainable community in line with the Green Deal initiative for environmentally friendly approaches towards circular economy.

Keywords: functional materials,flexible electronics,printing electronics,3d printing,green electronics,hybrid electronics,biosensors,smart diagnostic platforms,flexible energy sources,nanogenerators
Biomarker Enterprise to Attack DKD - Sofia ref.: 115974 (BEAt-DKD)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Austria,Austria,Germany,Germany,Germany,Germany,Italy,Germany,Germany,Germany,Germany,Italy,Germany,Finland,Finland,Finland,Switzerland,Sweden,Sweden,France,Netherlands,United States,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Denmark,United Kingdom
Call: Diabetic Kidney Disease Biomarkers (DKD-BM) (H2020-JTI-IMI2-2015-05-two-stage, 2015)
Start date: 2016-09-01
End date: 2023-08-31
Duration (months): 84.0
Total project cost (EUR): 30586654.14
EU funding (EUR): 15085937.0
Participants: 38
Project status: SIGNED

Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD), and its global incidence and prevalence have reached epidemic dimensions in recent years. Unfortunately, there are no effective means to prevent or cure DKD, the few existing treatments have limited effect and very few alternative therapies have emerged in the past years. Lack of new predictive and prognostic biomarkers for a more accurate patient stratification, limited access to kidney tissue from patients at various stages of DKD as well as novel model systems to better understand the pathogenesis of the disease, are likely reasons for the stagnating development of new treatments. The BEAt-DKD consortium combines outstanding basic and translational researchers in nephropathy, diabetes, kidney model systems, imaging techniques and systems biology, and includes leaders of diabetes and kidney disease-relevant IMI1, FP7 and US consortia, like SUMMIT, KIDNEYCONNECT, Syskid, CPROBE and C-Path, in an unprecedented search for new and better biomarkers for DKD, through a better understanding of the disease. Jointly, the partners have access to vast and very relevant clinical cohorts and trials, state-of-the-art analysis and imaging techniques, novel model systems and the long-standing experience and networks to make this collaboration a success. By involving regulatory agencies throughout the project, BEAt-DKD aims at making the introduction and acceptance of new tools as efficient as possible. The overall goals of BEAt-DKD are (1) to provide a holistic systems medicine view of the pathogenesis of DKD with the aim to identify targetable mechanisms and pathways underlying initiation and progression of DKD, applying a novel sub-classification of diabetes, and (2) to identify and validate biomarkers of disease progression and treatment responses representing first steps towards precision medicine in the management of DKD.

Keywords: diabetes,nephropathy,kidney,prognostic and predictive biomarkers,personalized medicine,imaging biomarkers,clinical trials,omics,diabetic kidney disease pathogenesis,mechanisms and pathways
The developmental and evolutionary basis of human intersubjectivity (DEVOLEMPA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Finland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2018-02-14
Duration (months): 24.0
Total project cost (EUR): 179325.6
EU funding (EUR): 179325.6
Participants: 1
Project status: CLOSED

This research aims to unravel the ontogenetic and phylogenetic roots of the unique human intersubjectivity. Empathy forms the basis of intersubjectivity. In the first part of the research, we address empathy development in young, 6-16-month-old infants who engage in interactive, intentional communication but do not yet cognitively represent others’ mental states. They may, however, attend to and show concern of others’ emotional states, indicating dispositional empathic orientation. This tendency is tested in a peer context, involving emotions of positive and negative valence. In addition, we assess the infants’ early communicative and prosocial behaviours in the emotionally charged situation. This will reveal the early developmental phases of the fundamental base for intersubjectivity. In the second part of the research, the evolution intersubjectivity is tested by assessing empathy in non-human primates. According to the recent cooperative breeding hypothesis, humans evolved as cooperative breeders, which increased sensitivity and motivation to attend to and show concern of others’ emotional states. The hypothesis is tested by assessing rudimentary empathy in common marmosets, a distantly related cooperatively breeding monkey. To allow full comparability, we will use identical methods in the infant and the marmoset studies. The study incorporates theoretical backgrounds and methods from several disciplines, i.e., comparative cognition, animal behaviour, developmental psychology, evolutionary anthropology, and sociological interaction research. The multidisciplinary approach yields understanding of the emotional and cognitive foundation of intersubjective interactions no single discipline can achieve alone. Moreover, the study yields fruitful prospects for future research lines in the respective disciplines and their synthesis.

Keywords: intrsubjectivity,empathy,comparative psychology,infant development,emotions,interaction,cooperative breeding,human evolution,marmoset monkey
Breaking the Mould: A cross-cultural analysis of the character of bronze smiths and craft diversity in late Bronze Age Europe (1300-800 BC) (BREAKING THE MOULD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

During the late Bronze Age in Europe (c. 1300-800BC) there was a transition in metal consumption from a restricted-access prestige material to a common medium for making practical objects. The objective of this project is to characterise culturally particular developments in bronze workshop practices using case-study areas in Europe, and through this to rethink relationships linking resource control, craft organisation and identity formation. This is achieved by measuring variability in the technological choices, skillsets and knowhow underlying smithing traditions and defining the social practices of craft production. I will employ a cross-cultural approach using three case studies: the Balkans, Central Europe and Northwest Europe. Multidisciplinary diagnostics will be used to assess technological markers that reveal intentional differences in production techniques. Methods will include 1) collating and analysing metallurgical datasets 2) recording and 3D modelling of craft traces on artefacts, 3) experimental bronze casting and material analysis. I will use these to build the first pan-European metallurgical digital resource, making specialist data more accessible and better enabling international collaborative actions. By moving to UCD, I will work closely with Aidan O’Sullivan, director of the Centre for Experimental Archaeology and Ancient Technology. Resources there and in the School of Archaeology provide a unique constellation for training in bronze object casting, forging and mechanical testing, along with digital 3D rendering of artefacts and data management. My career goal is to be a research leader in experimental archaeology, which this project will enable by developing a novel integrated kinaesthetic and scientific method for the study and visualisation of bronze metalworking. Through training in core and complementary skills, including teaching, supervision, and public outreach, I will develop key resources to maximise the impact of my career restart.

Keywords: experimental archaeology,experiential archaeology,kinaesthetic,bronze age,archaeometallurgy,metal smith,craft,ancient technology,metalworking,metallurgy,casting