Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
BioMensio mobile biosensing platform: the first truly palm-sized and accurate digital multi-drug test (BioMensio)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-03-01
End date: 2022-03-31
Duration (months): 37.0
Total project cost (EUR): 4060405.0
EU funding (EUR): 2492021.0
Participants: 1
Project status: CLOSED

In the EU, well over 8 million people have been found to drive under the influence of illicit drugs. In the US, fatal traffic accidents caused by drugged driving has already surpassed alcohol-induced traffic deaths. Drug intoxication testing is an efficient mechanism that helps to avoid drug related fatalities, such as traffic accidents or heavy machinery mishandling. However, the current testing solutions are not suited for wide scale deployment and thus cannot make a meaningful impact in the war against drugs. They are hampered by the bulkiness and high cost of instrumentation, uncertain levels of accuracy, and inability to detect the growing variety of drugs. BioMensio multi-drug testing platform is the first palm-sized and highly accurate device to detect drug intoxication from saliva, designed specifically for the police to detect drugged drivers, paramedics to better understand patient condition, and employers to prevent workplace injuries. Our patented bio-sensing technology enables to simultaneously measure a person’s intoxication from virtually any widely used narcotics, in an easy-to-administrate test that provides results in just 1-2 minutes. This by far exceeds the performance of any other current or up-and-coming technology. BioMensio is a spin-off company from Siemens Technology Accelerator and VTT Technical Research Centre of Finland, and has been backed with €3.5 million early stage funding. We are now beyond the proof-of-concept phase and are ready to scale our technology. We target the globally growing €1 billion saliva-based rapid drug testing market, which is fuelled by increasingly stringent government norms and workplace drug testing legalisation worldwide. As the key to reduce drug related fatalities and injuries is widely deploying and applying preventative tools, the main goal of our project is bring our patented bio-sensing platform to the mass market.
Backreaction of Financial Networks: Risk Estimation and Asset-Management (FinNet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Germany,Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2021-03-01
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 2
Project status: CLOSED

The financial market is a relevant part of our economy. Its crisis spread all over the countries and affect our daily life. Understanding these phenomena has become a crucial field of academic research and a holy grail for investors. In this project, I aim to study and develop models to forecast and manage the risk propagation along simplified structures called dynamical networks with particular emphasis on the morphological changes occurring as back-reaction to the risk spread.

Keywords: dynamical networks,correlation networks,back reaction
TailorFit; The Integrated “made to measure” workflow automation for menswear (TailorFit)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project targets all luxury fashion firms that specifically manufacture classic menswear clothing (i.e. shirts, jackets, pants, coats...) and propose its personalisation. On one hand, personalisation is a great opportunity to provide the final clients with the cloths they desire, but on the other luxury fashion houses are facing the increasing need of having some automated solutions that will help them in creating "customized product" in a faster lead time. In fact all fashion houses manufacturing menswear are focused on providing Made to Measure products to their customers, because it increases their revenues, but at the same time this also increases their costs. An integrated and automated management of the whole value chain will decrease the lead time, increase customization application and decrease costs. Crea Solution Srl proposes the TailorFit solution that will dramatically accelerate the timing of the whole process, by managing every step of the cloths manufacturing: 1) Acquisition of body measures and selection of the type of clothing, collected in a store anywhere in the world or online, 2) Outfit design: data are sent to an intelligent CAD-based system that will generate the optimal person-tailored outfit design starting from the chosen cloths model, 3) Outfit manufacturing: a software will identify the optimized fabric cut according to the tissue and its physical characteristics (i.e. the deformation of the fabric) and then will cut it rapidly allowing time and fabric savings. TailorFit solution is innovative compared to existing ones as those do not provide the management of the entire process, but rather they separate it into parts, do not allow customers to have an integration with the web, do not handle the perfect cut of fabrics and cutting times are operational only for striped fabrics and paintings.

Keywords: reduced lead time,made to measure menswear,tailoring automated process,precision automated fabric cutting
Continuation of the efforts of the local Enterprise Europe Network to further enhance the Innovation Management Capacity of Cypriot SMEs (KAM2CY 2) (KAM2CY2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Cyprus
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 48547.5
EU funding (EUR): 48547.5
Participants: 3
Project status: CLOSED

Continuation of the efforts of the local Enterprise Europe Network to further enhance the Innovation Management Capacity of Cypriot SMEs (KAM2CY 2) The project envisages the continuation of specialised coaching services addressing the innovation management capacity of Cypriot SMEs in order to increase the efficiency and effectiveness of investments in research, development and innovation. The Research Promotion Foundation (RPF), is currently implementing a similar project funded by the EC (KAM2CY), which provides the local SMEs with Key Account Management services (KAM). The project aims to contribute to a better and more efficient connection of local SMEs along with the innovation chain. This will result to a smart growth of Cypriot SMEs and consequently of the Cypriot economy in general. The services will continue to be offered by RPF, as a bundle of additional specialised services, aiming to increase and accelerate economic returns of innovation. RPF is the coordinating organisation of the Business Support Centre in Cyprus (BSC-Cy), the local member of the Enterprise Europe Network (EEN).

Keywords: innovation management
Metal-detected past: a study of long-term developments in settlement patterns, technology and visual culture on the example of metal-detector finds from Estonia (MetDect)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Estonia
Call: Widening Fellowships (H2020-WF-02-2019, 2019)
Start date: 2020-09-01
End date: 2023-09-21
Duration (months): 24.0
Total project cost (EUR): 142193.28
EU funding (EUR): 142193.28
Participants: 1
Project status: SIGNED

MetDect examines long-term developments in the settlement patterns, local production of ornaments and visual culture by using metal-detector finds from Estonia. Despite the inherent limitation of the data (uneven level of contextual and empirical information), MetDect will demonstrate that the vast amount of metal-detector finds will significantly advance our current knowledge about the past. Unlike many other studies, this project focuses on the full variability of detected-artefacts in a long temporal scale (1800BCE–1800CE). MetDect will use a combination of methods drawn from humanities and natural sciences for investigating each topic. Settlement patterns and workshop areas will be examined by using GIS mapping and spatial analysis (e.g., point-pattern analysis), but production series of ornaments will be distinguished stylistically. Local production of ornaments is further examined by determining chemical composition (bulk alloy and trace elements) of selected production series. Lastly, new types and form variations of artefacts that are discovered by private detectorists will be compared with other visual sources (architectural and artefactual) in order to discuss circulation of ideas related to cross symbolism. MetDect will launch the first open-access database on metal-detector finds in the Eastern Baltic. Further, the results of this project will provide an important contribution to a wider debate regarding the usage of metal detectors by private persons. As such, MetDect offers a novel and ambitious research programme for studying metal-detector finds in the Baltic Sea area and beyond.

Keywords: metal detecting,settlement patterns,production of ornaments,visual culture,baltic sea area
Mechanical contribution of starch granules in the stabilization/destabilization of cell walls during bread baking (MECASTARCH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-11
End date: 2023-10-10
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

Wheat-based bread is a staple food in the European and North American diet, presenting a relevant economic importance. Early successes in the wheat selection (high in gluten) along with the use of additives (surfactants, supplementation in gluten) to smooth out the variability in batch-to-batch performance of wheat flours reduced the incentive to carry out in-depth characterization of the roles played by other flour ingredients in the inflation process during bread baking. However, supplies of bread-quality wheat are being threatened by climate-induced variability, while consumers are more critical regarding the use of food additives and more demanding of clean-label products. In this scenario, the bakery industry will demand a transformation and alternatives such as flour blending will become a hot topic. In order to obtain breads with similar performance, it is crucial to understand the exact role played by flour ingredients other than gluten in breadmaking, especially starches (~80% of the wheat flour). In this context, the MECASTARCH project proposes a cutting-edge approach of computer modelling offering the possibility to decouple the multiple roles played by starch in the stabilization/destabilization of Gas Cell Wall (GCW) during baking and focusing on the mechanical contribution of starch. Several experimental approaches applied to a selection of starches will feed this computer modelling, including rheometry on moderately hydrated starch, starch/gluten interactions by AFM, and morphometric observations of GCW by sophisticated microscopy. On the one hand, the fellow will share her large experience in the characterization and evaluation of starches with the host. On the other hand, the host will contribute to develop her scientific skills related to material science, as well as her management skills. The project will deeply contribute to the career development of the fellow who aims at promoting a holistic approach from her background science in a near future

Keywords: food processing,baking,bread dough,gas bubble,aeration,expansion,thermo reaction,starch,polymeric film,computational modelling,rheology,microscopy,multi scale imaging
Endosome positioning in tumour-stroma interactions (EndoPos)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-06-28
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Endocytosis of cell surface receptors controls signaling during proliferation, differentiation and migration of cells, and plays a significant role in cancer progression. Invasive cancer cells accumulate recycling endosomes (including Rab11) at protrusions. This promotes the delivery of integrins, receptors for extracellular matrix, to regulate interactions between tumour cells and their surroundings, and coordinates actin polymerization through Rho family GTPases. The Rab11 family is particularly important in determining the aggressiveness of high-grade serous ovarian carcinoma (HGSOC). Despite its importance, the machinery that guides Rab11 trafficking and the functions of polarized trafficking are not clear in HGSOC. I aim to determine how recycling endosomes are positioned within HGSOC cells invading extracellular matrix, using BioID-based proteomics (a proximity labelling approach well established in the host lab) to identify the Rab11-associated machinery in HGSOC cells. I further aim to actively manipulate the dynamics of Rab11 positive endosomes in invading cells by developing a magnetogenetic approach to reposition endosomes in live cells, using a combination of my developed skills (including live imaging, protein engineering). Both cutting-edge methods will be applied in the most physiological and cancer relevant context to lend clinical relevance to our observations. Combining these innovative approaches will provide molecular detail and mechanistic insight to elucidate how localised endocytic trafficking controls tumour-stroma interactions in the metastatic niche and contributes to HGSOC lethality. This work will further provide targets for therapies aimed at suppressing metastasis and preventing relapse in HGSOC, a lethal form of ovarian cancer that has one of the worst survival rates (<40% 5-year survival). Moreover, this project will allow me to acquire technical skills and expertise essential for my development as an independent researcher.

Keywords: endocytic trafficking and recycling,cell invasion into extracellular matrix,high grade serous ovarian cancer
Hexahedral mesh generation in real time (HEXTREME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Belgium
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2021-09-30
Duration (months): 60.0
Total project cost (EUR): 2244237.5
EU funding (EUR): 2244237.5
Participants: 1
Project status: CLOSED

Over one million finite element analyses are preformed in engineering offices every day and finite elements come with the price of mesh generation. This proposal aims at creating two breakthroughs in the art of mesh generation that will be directly beneficial to the finite element community at large. The first challenge of HEXTREME is to take advantage of the massively multi-threaded nature of modern computers and to parallelize all the aspects of the mesh generation process at a fine grain level. Reducing the meshing time by more than one order of magnitude is an ambitious objective: if minutes can become seconds, then success in this research would definitively radically change the way in which engineers deal with mesh generation. This project then proposes an innovative approach to overcoming the major difficulty associated with mesh generation: it aims at providing a fast and reliable solution to the problem of conforming hexahedral mesh generation. Quadrilateral meshes in 2D and hexahedral meshes in 3D are usually considered to be superior to triangular/tetrahedral meshes. Even though direct tetrahedral meshing techniques have reached a level of robustness that allow us to treat general 3D domains, there may never exist a direct algorithm for building unstructured hex-meshes in general 3D domains. In HEXTREME, an indirect approach is envisaged that relies on recent developments in various domains of applied mathematics and computer science such as graph theory, combinatorial optimization or computational geometry. The methodology that is proposed for hex meshing is finally extended to the difficult problem of boundary layer meshing. Mesh generation is one important step of the engineering analysis process. Yet, a mesh is a tool and not an aim. A specific task of the project is dedicated to the interaction with research partners that are committed to beta-test the results of HEXTREME. All the results of HEXTREME will be provided as an open source in Gmsh.

Keywords: mesh generation
An innovative axial turbine for conversion of hydro-kinetics energy to electricity in rivers and canals (HyKinetics)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2020-01-01
End date: 2023-06-30
Duration (months): 42.0
Total project cost (EUR): 2192125.0
EU funding (EUR): 1534487.5
Participants: 2
Project status: SIGNED

HyKinetics is an innovative and patented 3-blades axial 20 kW micro hydroelectric generator, able to competitively exploit the hydro-kinetics energy of the flowing water, specifically designed for exploitation of renewable energy on rivers and canals, not using dams or waterfalls. HyKinetics is the first product on the market for micro hydropower sector (< 100 kW) able to achieve a Cost of Electricity of comparable with large hydro plants, solar photovoltaic, biomass and geothermal power technologies and presenting a very limited visual and environmental impact, very important for river applications, subjected to stringent environmental constraints. To enter the market with a standardized and easily accessible market, COSBI targets to address as entry point the installation to canals downstream of dam-based hydroelectric power stations, increasing production of existing large hydro power plants of >5%, i.e 17 TWh/year if applied in all hydropower plants in EU28 (the annual electricity consumption of Slovenia). The potential and acceptance of this market segment has been demonstrated by means of a Customer Validation methodology (discussion and agreements with big players owners of large hydropower plants). The Total Available Market of this segment in Europe amounts to 12.2 GW, able to generate a turnover of 26.8 B€. Then, after entering the market, COSBI will face the huge rural electrification sector, with a market potential of up to 40 B€. The objectives of the project are: 1) Manufacturing of 5 HyKinetics prototypes (Minimum Viable Product); 2) Installation and validation of the prototypes in real testing sites already selected; 3) Achieve the certifications needed for commercialization and optimization of industrial production to reduce cost of production ; 4) Increase market awareness and demonstrate results to potential clients for product launch just after the project.

Keywords: micro hydropower plant,axial hydropower turbine,in river kinetic energy exploitation,hydroelectric generator
Detecting, understanding and exploiting intracellular redox signaling relays (Redox Relays)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2024-03-31
Duration (months): 78.0
Total project cost (EUR): 2006250.0
EU funding (EUR): 2006250.0
Participants: 1
Project status: SIGNED

Redox signaling is a process by which endogenous oxidants, derived from metabolism, reversibly modify particular thiols on particular proteins to change their functional behavior in an adaptive manner. However, the molecular mechanisms of redox signaling remain largely unknown. In particular, specificity and efficiency of redox signaling remain unexplained. The now emerging solution to this conundrum is that redox signaling is mediated and channeled by protein-to-protein redox relay chains that dynamically assemble in the cytosolic, nuclear and mitochondrial compartments. We and others have found that H2O2 signals are relayed through thiol peroxidases to neighboring proteins within supramolecular assemblies. Evidence now suggests that so far we have just glimpsed the ‘tip of the iceberg’, namely that redox relay chains are ubiquitous and also operate for reactive nitrogen and sulfur species. This project aims to systematically uncover, dissect, monitor and manipulate the redox relay chains that give specificity and efficiency to redox signaling. The basic strategy is to tag all protein-coding genes with genetically encoded reporters which –within the context of the living cell– sense the transmission of thiol oxidizing equivalents within their sphere of immediate proximity (≈10 nm). A combination of genetic screening, redox proteomics and transcription profiling will then allow to identify the composition of redox relays, their endogenous target proteins und their functional impact on gene regulation. The knowledge about the composition of redox relays will lead to precision tools for the observation and manipulation of defined redox signaling pathways in vivo. The project is expected to yield fundamental insights into the specific molecular links by which reactive oxygen, nitrogen and sulfur species couple changes in metabolism to cellular and organismal adaptations regulating resilience and healthspan.

Keywords: redox signaling,redox regulation,protein thiol oxidation