Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Projection-based Control: A Novel Paradigm for High-performance Systems (PROACTHIS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-11-01
End date: 2028-10-31
Duration (months): 72.0
Total project cost (EUR): 2498516.25
EU funding (EUR): 2498516.0
Participants: 1
Project status: SIGNED

The field of control has been a key driver for major societal innovations in health, mobility, energy and manufacturing. At present, technological trends push the performance requirements for future applications to extreme levels that are far beyond current control solutions. Existing linear controllers for linear systems are supported by user-friendly time- and frequency-domain design tools, yet they lack the flexibility to overcome fundamental performance tradeoffs. Full nonlinear control structures provide the desirable flexibility, but they lack comprehensive frequency-domain design techniques. These observations indicate a lack of flexible control structures accompanied by systematic design and online optimization frameworks exploiting time- and frequency-domain information to realize the unparalleled performance needs of future engineering systems. In PROACTHIS, I will bridge this scientific gap by creating a new control paradigm based on projection operators. By introducing projections in control loops, specific signals are kept in well-chosen constraint sets inducing direct performance-enhancing benefits. I foresee that the mathematical structure of these projection-based controllers enables fundamental properties that were instrumental in the success of linear control and will be key to obtain effective design frameworks for this new class of hybrid controllers. Developing projection-based control theory has high risks, as even the mathematical formalization of these control schemes leads to a new class of dynamical systems never studied before. This scientific challenge calls for leveraging powerful multi-disciplinary methodologies from Hybrid Systems, Control Engineering, Networked Systems, Learning and Mathematics. Successfully developing this new system theory will pave the way towards game-changing cutting-edge control methodologies addressing the needs of future engineering systems, thereby enabling new breakthroughs in important societal domains.

Keywords: hybrid systems,stability,control systems,networked systems,networked control systems,projected dynamical systems,piecewise linear systems,linear matrix inequalities,iterative learning control,extremum seeking,circle criterion,integral quadratic constraints,frequency response functions,projection,lure systems,linear parameter varying systems,switched systems
A synaptic mechanogenetic technology to repair brain connectivity (SynMech)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Germany,Netherlands,Hungary
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-02-01
End date: 2028-01-31
Duration (months): 60.0
Total project cost (EUR): 3543967.5
EU funding (EUR): 3543967.0
Participants: 8
Project status: SIGNED

We aim to develop a mechanogenetic technology to regulate functional connectivity of neural circuits, and show how it can be harnessed for therapeutic purposes in high-prevalence treatment-resistant brain disorders. Mechanogenetics is an emerging field of health science that attempts to regulate neural networks by combining the advantages of optogenetics with those of magneto-mechanical stimulations; like optogenetics, it relies on targeted actuators to achieve circuit specificity, while exploiting magnetic fields to remotely stimulate the brain. Yet, despite solid theoretical foundations and encouraging experimental results, we are to date unable to repair a dysfunctional brain using mechanogenetics due to technological barriers in spatial resolution and in vivo implementation. We propose an innovative solution based on functionalized biocompatible magnetic nanoparticles and bioengineered synaptic mechanosensors that synergistically integrate at specific synaptic connections to bidirectionally regulate brain circuit connectivity in response to focused magnetic fields of different frequencies delivered via high-permeability transcranial magnetic stimulators. By hijacking the signaling pathways of synaptic mechanosensors, we aim to promote a normalization of neural circuit activity that outlasts the therapeutic intervention. We will assess the capacity of the synaptic mechanogenetic toolkit to promote and depress network activity in mouse models of stroke and epilepsy. To achieve this ambitious goal, we have gathered an interdisciplinary consortium going from material scientists and electronic experts to physiologists and clinicians. Our approach, based on magnetic fields that penetrate brain tissue unimpeded, is predicted to go beyond current therapeutic paradigms because it does not require implantation of invasive devices, and at the same time, promises to achieve subcellular resolution for repairing connectivity defects that underlie most brain disorders.

Keywords: cell adhesion molecules,extracellular matrix,magnetic nanoparticles,transcranial magnetic stimulation,synaptic physiology
An integrated toolbox for improved verification and prevention of adulterations and non-compliances in organic and geographical indications food supply chain (THEROS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Innovation actions
Countries involved: Greece,Slovenia,Spain,Cyprus,Czechia,Serbia
Call: Innovative solutions to prevent adulteration of food bearing quality labels: focus on organic food and geographical indications (HORIZON-CL6-2022-FARM2FORK-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 4739281.75
EU funding (EUR): 3999691.0
Participants: 18
Project status: SIGNED

THEROS aims to implement an integrated toolbox being capable to modernise the process of verifying organic and geographical indications food products and preventing adulterations and non-compliances, through the use of various technological innovations and data sources and while demonstrating enhanced security, transparency and interoperability in the quality labelled food supply chain. The envisioned approach consists of : i) low-cost, digital and scalable solutions that rely on Earth Observation, photonics, Internet of Things and DNA authenticity methods being coupled with advanced analytics, machine learning and artificial intelligence in order to ensure efficient detection of fraudulent cases as well as monitoring of associated quality and sustainability elements ii) blockchain enhanced traceability system and dynamic digital product passport for improved traceability, security and transparent data governance iii) platforms and algorithms allowing management and harmonisation of heterogenous data as well as their consolidation for the verification and validation of transactions across the supply chain iv) interfaces to facilitate monitoring and inspections by competent authorities, informed decision making by supply chain actors and policy makers as well as business model driven approaches to support short supply chains of quality labelled food products. THEROS toolbox components will be extensively evaluated in real life settings through four pilot demonstrations in four different countries and while covering diverse requirements, involvement of all relevant actors and different organic/geographical indication food products and fraud/adulteration cases.

Keywords: organic and geographical indications supply chain,earth observation,photonics,machine learning,artificial intelligence,dna based authenticity,interoperability
Lightning corona Imaging From a radio Telescope (LIFT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 2124988.0
EU funding (EUR): 2124988.0
Participants: 1
Project status: SIGNED

We do not understand how lightning in our atmosphere initiates, nor how it develops and propagates after initiation. The fundamental difficulty is that these basic lightning phenomena are driven by the meter-scale dynamics of the low-conductivity plasma that surrounds the lightning channel, known as the corona, but the dynamics of this corona is as-yet unresolved. Resolving the structure of the lightning corona and how it develops in time is the holy grail of lightning science, as it will reveal the mechanism behind lightning initiation, the physics behind how lightning channels grow and propagate, and why lightning emits intense flashes of X-ray and gamma ray radiation. During the LIFT project I will develop new advanced data processing techniques, including polarization imaging and interferometric beamforming, to produce meter-scale and nanosecond precise radio-frequency images of lightning activity. This project will use data collected by the LOw Frequency ARray (LOFAR) radio telescope, which previous work has shown to be the most precise and sensitive lightning interferometer in the world. The end result of this project will be finely resolved images of lightning corona that are an order-of-magnitude more precise than all previous work. Since it is the coronal plasma that drives most other lightning processes, the impact will be a fundamentally deeper insight into the physics of lightning initiation, propagation, and emission of energetic radiation, including resolving long-standing questions of how cosmic rays or hydrometers could be involved in lightning initiation, how lightning expands from a single point to a kilometer-scale network, and which key plasma processes allow lightning channels to grow. In addition, the LIFT project will make use of the drastically increased bandwidth and processing power that will be made available during the LOFAR 2.0 upgrade in order to push the observations to even higher spectral and spatial precision.

Keywords: lightning,radio interferometry,radio telescope,plasma physics
Consortium Europe-Africa for Research and Innovation on Food Systems Transformation (CEA-FIRST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Coordination and support actions
Countries involved: Ghana,France,Belgium,Netherlands,South Africa,Sweden,Uganda,Burkina Faso,Germany,Italy,Egypt,United Kingdom,Senegal,Finland
Call: Support for the implementation of a sustainable platform for the EU-African Union cooperation under the Food and Nutrition Security and Sustainable Agriculture (FNSSA) partnership (HORIZON-CL6-2023-FARM2FORK-01, 2023)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 3319038.22
EU funding (EUR): 3319038.22
Participants: 22
Project status: SIGNED

CEA-FIRST, the Consortium Europe Africa on Research and Innovation for Food Systems Transformation, consists of 21 partners from Africa and Europe, partly from the former LEAP4FNSSA, extended with new public and private network partners. CEA-FIRST will operationalise the International Research Consortium (IRC) as a long-term platform on food and nutrition security and sustainable agriculture (FNSSA) in line with the FNSSA Roadmap of the AU-EU High-Level Policy Dialogue (HLPD). This IRC is a member-based, multi-actor platform and will work towards increasing synergies and coherence while reducing fragmentation and duplication of research efforts. Its aim is to promote higher returns on investments and impact on business development in Africa and Europe, by linking actors, research and innovation projects, initiatives, and funding programmes. CEA-FIRST will: 1. provide public access to a large knowledge platform, 2. offer a sound method for analysis of R&I activities, 3. support the updating of the FNSSA Roadmap, 4. establish operational working groups and thematic research calls. The final output will be a fully functional IRC, including governance bodies. CEA-FIRST will also support its liaison with the High-Level Policy Dialogue (HLPD). It will create a learning environment, including communication channels, to support multi stakeholder networks and to strengthen R&I coordination. The IRC will also serve related AU-EU policy priorities, such as the Climate Change and Sustainable Energy and the Innovation Agenda of the HLPD, as well as the European Green Deal priorities (and farm to fork strategy) and the AU priorities like the African Free Trade Area.
Understanding Arctic amplification of climate change through air-mass transformations (A3M-transform)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1468938.0
EU funding (EUR): 1468938.0
Participants: 1
Project status: SIGNED

We expect that temperatures over the wintertime central Arctic will increase by 20 degrees - and precipitation will double - by the end of this century if greenhouse gas emissions continue to rise. Arctic sea-ice is projected to completely melt in summer within the next decades, and may cease to form in winter in the coming century. The traditional framework to understand this Arctic amplification of climate change focuses on the steady-state mean Arctic climate. However, the Arctic wintertime atmosphere has two preferred states that are largely controlled by initially warm and moist air masses that cool and dry after being advected from lower latitudes. We understand little about how these air masses cool and dry, and what controls the sudden transition from a cloudy state to a clear state along their trajectory. This lack of understanding is a major obstacle to scientific progress and improved climate models. To achieve groundbreaking progress, I will analyze the warm, moist poleward flows, cold, dry equatorward flows and the air-mass transformations that lead from one to the other. I will observe and model such air masses along their trajectories using recently developed air-mass following balloons and customized model setups. Cooling of air in the Arctic mirrors heating in the Tropics. Together, these drive the global atmospheric circulation, but the Arctic’s role in this picture has largely been overlooked. My team will investigate how the Arctic couples to the global climate system using a novel concept of averaging the atmospheric circulation. We will focus on how and why both the heat and moisture content and the amount of air transported into and out of the Arctic change in a warming world and contribute and respond to Arctic amplification. A3M-transform will deliver a step change in understanding the air-mass transformation processes that shape Arctic amplification and transform our view of how the Arctic couples to the global climate system.

Keywords: arctic amplification,climate change,clouds,atmospheric boundary layer
Understanding how different condensin activities regulate mitotic chromosome folding in human cells (Chromofold)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

In human cells, the SMC complex condensin plays a significant and essential role in chromosome condensation, but there is conflicting data. Studies from other groups have suggested that the loop extruding activity of condensin is important for chromosome folding, but a study from my host lab suggested that loop extrusion (LE) alone is not able to package chromosomes. Using molecular biology experiments and polymer simulations they hypothesized that condensin has an additional bridging induced phase separation (BIPS) activity that is required for correct chromosome folding. In its absence, chromosomes are not fully compacted leading to chromosome instability. I will collaborate closely with polymer physicists in Edinburgh to interpret experimental data and to understand how different condensin activities are necessary for chromosome folding. Together, we expect to provide a new model of condensin molecular functions based on experiments in vivo analyzed together with simulations of mitotic chromosomes. Deviations between simulations and experiments will be used to identify gaps in our knowledge leading to new hypothesis generation. My aim is to investigate how different condensin activities (BIPS vs LE) regulate mitotic chromosome folding. To achieve this I have the following objectives: (i) Use an in silico model of condensin-mediated chromatin folding with diverse levels of LE and BIPS to develop models of chromosome folding and generate testable hypotheses and predictions. (ii) In human cells replace endogenous condensin components with already identified separation of function mutants to alter the balance between BIPS and LE activities and assess their role in chromosome folding. (iii) Explore how different mutations affect condensin binding and clustering on mitotic chromosomes using super-resolution microscopy.

Keywords: smc complex,mitotic chromosome,condensin,separation of function,loop extrusion,simulation,genome organization,chromatin folding
European Lighthouse of AI for Sustainability (ELIAS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Countries involved: Italy,Netherlands,France,Germany,Spain,Greece,Denmark,Slovenia,Czechia,Sweden,Poland,Romania,Ireland,Hungary,Switzerland,Finland,United Kingdom
Call: European Network of AI Excellence Centres: Expanding the European AI lighthouse (RIA) (HORIZON-CL4-2022-HUMAN-02, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 11030575.01
EU funding (EUR): 11030575.0
Participants: 37
Project status: SIGNED

We live in a crucial historical moment, with tremendous challenges ahead, from climate change to the energy crisis. ELIAS emerges from the belief that AI will be a key discipline to help us tackle these challenges. At the same time, the development of AI entails deep ethical and societal concerns that need to be addressed. As for fundamental research, ELIAS will address key scientific questions about how AI can reduce computational costs, serves to model effects of policy decisions on society, and impacts individuals. ELIAS will strive for a deep integration of the fundamental research that takes place in academia and the more applications-focused research from industry. ELIAS builds on and expands the highly successful and internationally recognized European Laboratory for Learning and Intelligent Systems (ELLIS). ELIAS will further develop the excellence criteria and the pillars in ELLIS and implement actions that will support AI researchers and young talents at different stages of their careers. Furthermore, ELIAS will develop a Sciencentrepreneurship track, with the purpose of attracting and empowering talents at the interface of scientific innovation and business and establish original AI solutions that move towards a sustainable long-term future for our planet, contribute to a cohesive society, and respect individual rights. The outcome of ELIAS will be to establish Europe as a leader in AI research in which impact on the environment, society and the individual are integral considerations during development. We will measure the success of this endeavor in terms of key indicators, including the number of new cross-institutional collaborations, the number of cross-disciplinary collaborations, the number of industry-academic partnerships, publications in top conferences and journals, patents, and the number of projects that have resulted in deployed technologies.

Keywords: sustainable technologies,trustworthy and responsible ai,ai for a sustainable society,ai talents,entrepreneurship and technology transfer