Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Modelling the impact of resource competition, human expansion and climate on extinction (RESOURCEFUL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2026-09-12
Duration (months): 36.0
Total project cost (EUR): 337400.64
EU funding (EUR): 337400.64
Participants: 1
Project status: SIGNED

This MSC Action will investigate the interplay of behaviour, climate, and human pressure on species extinction, using a highly interdisciplinary approach uniting theoretical population modelling with palaeogenomics. This MSC Action will investigate the interplay of behaviour and population structure on extinction risk in species that rely on geographically fixed resources. It will focus on long extinct cave bears by utilising a highly interdisciplinary approach uniting theoretical population modelling with palaeogenomics to test the causes of their extinction. The host organisation, Prof. Manica’s UCAM Group, is a world-leading research group in population genetics and modelling. I will be provided with training and development opportunities that allow me to build a spatially explicit computational model of cave bear populations that use multiple caves for hibernation. Development of my existing knowledge of palaeogenomics during secondment in Dr. Barlow’s TNTU Lab will allow me to assemble a population level sample of contemporaneous Romanian cave bear genomes to further refine the model based on empirical data. Finally, this refined cave bear population model will allow, for the first time, a detailed and statistically robust assessment of the effect of human competition for caves on cave bear extinction. This MSC Action provides numerous opportunities for my training and personal development, by locating myself in the world-leading UCAM Group, attendance of five formal training courses, and further opportunities during the secondment and visits to other labs. It will result in internationally significant research outputs that will be disseminated to the scientific community via publications and presentations, as well as to different target audiences via public engagement, media and teaching activities. Moreover, it will provide numerous vital steps towards my ultimate career goal of establishing a world-leading research group within the field of palaeogenomics

Keywords: palaeogenomics,ancient dna,population modelling,population dynamics,extinction,cave bears,ursus spelaeus
Actively Enhanced Cognition based Framework for Design of Complex Systems (AGNOSTIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Sweden,Luxembourg
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2023-09-30
Duration (months): 72.0
Total project cost (EUR): 2499595.0
EU funding (EUR): 1843447.0
Participants: 2
Project status: SIGNED

Parameterized mathematical models have been central to the understanding and design of communication, networking, and radar systems. However, they often lack the ability to model intricate interactions innate in complex systems. On the other hand, data-driven approaches do not need explicit mathematical models for data generation and have a wider applicability at the cost of flexibility. These approaches need labelled data, representing all the facets of the system interaction with the environment. With the aforementioned systems becoming increasingly complex with intricate interactions and operating in dynamic environments, the number of system configurations can be rather large leading to paucity of labelled data. Thus there are emerging networks of systems of critical importance whose cognition is not effectively covered by traditional approaches. AGNOSTIC uses the process of exploration through system probing and exploitation of observed data in an iterative manner drawing upon traditional model-based approaches and data-driven discriminative learning to enhance functionality, performance, and robustness through the notion of active cognition. AGNOSTIC clearly departs from a passive assimilation of data and aims to formalize the exploitation/exploration framework in dynamic environments. The development of this framework in three applications areas is central to AGNOSTIC. The project aims to provide active cognition in radar to learn the environment and other active systems to ensure situational awareness and coexistence; to apply active probing in radio access networks to infer network behaviour towards spectrum sharing and self-configuration; and to learn and adapt to user demand for content distribution in caching networks, drastically improving network efficiency. Although these cognitive systems interact with the environment in very different ways, sufficient abstraction allows cross-fertilization of insights and approaches motivating their joint treatment.

Keywords: signal processing,statistical signal processing,wireless communications,mimo communications,radar,mimo radar,cognitive radio,cognitive radar
Monsoons of Asia caused Greenhouse to Icehouse Cooling (MAGIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany,France,Netherlands
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-02-28
Duration (months): 66.0
Total project cost (EUR): 1999999.33
EU funding (EUR): 1108723.08
Participants: 3
Project status: CLOSED

Unraveling the cause for Cenozoic global climate cooling is one of the most important unresolved questions challenging the Earth and Environmental sciences community today. Increased erosion and weathering of the uplifted Tibetan Plateau and Himalayas, is advocated as the primary cause for the enigmatic pCO2 drawdown, that led to global cooling 50 to 34 Myrs ago from the warm ice-free Greenhouse world to the bi-polar Icehouse conditions still prevailing today. Asian Monsoons are genetically linked to high orography associated with the India-Asia collision starting ca. 50 Myrs ago, however, the relation between Greenhouse to Icehouse cooling and Asian Monsoons remains to be explore as they were previously thought to intensify only much later ca. 25 Myrs ago. Our recent findings of monsoonal activity in Asia since at least 45 Myrs ago raises the fascinating possibility that Asian Monsoons may have triggered global cooling from Greenhouse to Icehouse conditions. Testing this novel hypothesis and exploring its implications on feedback mechanisms between regional environments, Asian Monsoons and global climate, will constitute the stimulating objectives of MAGIC. 3 PhDs will provide end-member monsoonal archives well-dated during greenhouse to icehouse cooling from 3 key locations (NE Tibet, SE Asia and Paratethys Sea). These will be analyzed by three postdocs expert in novel proxy methods tailored for MAGIC to infer temperatures, precipitation, salinity, seasonality, paleoaltimetry, wind-patterns, paleoecology and paleogeography at infra-annual, orbital and tectonic time scales. Ultimately, these records and boundary conditions will be integrated into climate models by a dedicated postdoc to unravel the role and behavior of Asian Monsoons with respect to long-term Greenhouse to Icehouse cooling, pCO2 levels as well as global hyperthermal and cooling event such as the PETM, MECO and EOT.
Does a moving hybrid zone leave a genomic footprint? (GENOMIC FOOTPRINT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United States,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-02-01
End date: 2019-01-31
Duration (months): 36.0
Total project cost (EUR): 269857.8
EU funding (EUR): 269857.8
Participants: 2
Project status: CLOSED

Species are the currency of biodiversity. However, during the early stages of their evolution, species are difficult to delineate, as barriers to gene flow are not yet complete. Range expansions and contractions exaggerate the reshuffling of the genomes of hybridizing species. The key objective of this project is to experimentally test the theoretical prediction that, under hybrid zone movement, genes derived from a displaced species are left behind in the genome of an invading species, leaving a ‘genomic footprint’. I will fill an empirical void by, for the first time, testing this critical hypothesis in the wild, using genome-scale data. I have established a study system (the newt genus Triturus) that is particularly appropriate because it shows strong evidence in support of hybrid zone movement over considerable time and distance. To obtain genome-wide data, I will be trained in the cutting-edge genomic technique of target enrichment through sequence capture during the outgoing phase at the lab of Prof. Shaffer at the University of California, Los Angeles (UCLA). To transfer this important new piece of knowledge back to Europe, I will implement target enrichment through sequence capture during the return phase at the beneficiary, the University of Sheffield (USFD). At USFD the group of Prof. Butlin has unmatched expertise in hybridization/speciation research and excels in the analytical approaches required to uncover a genomic footprint. Human activities have intensified hybridization and I propose a secondment to work together with conservationists and legislators to tackle the insidious conservation problem of genetic pollution by exotic species.

Keywords: historical biography,hybridization,phylogeography,population genetics,sequence capture,speciation
Nanomechanical Switch-Based Logic and Non-Volatile Memory for Robust Ultra-Low Power Circuits (ZeroAMP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Sweden,Switzerland,Switzerland,United Kingdom,United Kingdom
Call: Unconventional Nanoelectronics (H2020-ICT-2019-2, 2019)
Start date: 2020-01-01
End date: 2024-06-30
Duration (months): 54.0
Total project cost (EUR): 3481243.75
EU funding (EUR): 3481243.75
Participants: 7
Project status: SIGNED

ZeroAMP is a project to develop a nanomechanical switch-based computing platform that will enable computing components with very high energy efficiency in harsh environmental conditions. Emerging applications such as the Internet-of-Things, all-electric vehicles and more-electric aircraft require electronics that can operate at high temperatures with very high energy efficiency. At the other end of the temperature spectrum superconducting quantum circuits operate at cryogenic temperatures (< 4K) when carrier freezeout in the classical control circuitry makes it a challenge to perform basic functions such as (de)multiplexing of qubits. We will demonstrate a field programmable gate array-like nanomechanical switch-based reprogrammable computing platform comprising logic and non-volatile memory to serve these emerging requirements. Our technology solution will use novel materials, switch designs and circuit techniques along with advanced 3D stacking for large-scale integration of the nanomechanical switching elements to achieve an energy efficiency and environmental capability that cannot be matched by CMOS or any experimental technologies currently on the horizon. ZeroAMP is an industry driven effort that involves three leading companies covering the entire semiconductor supply chain (MICROSEMI, XFAB and AMO), a leading research institute (CSEM), two top universities (University of Bristol and KTH) and an Exploitation Council with key European stakeholders across the different industries relevant to the technology. We cover the complete technology platform required for nanomechanical computing including 3D switch integration, design methodologies and packaging, as well as the entire supply chain with foundry partners and manufacturers. In summary, in ZeroAMP we will develop a novel nanoelectronic technology platform to deliver the first large-scale-integrated nanomechanical computing systems comprising a field programmable gate array and a non-volatile memory.

Keywords: nanomechanical switch circuit,nanoelectromechanical relay,bistable nems relay,robust nonvolatile memory,cryogenic temperature logic,high temperature,field programmable gate array,fpga
MAtchmaking Restoration, Ecology and Aquaculture (MAREA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-07-01
End date: 2023-12-26
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: SIGNED

Aquaculture expansion is a necessary step to respond to increase protein demands while limiting the reliance on wild fisheries and imports.Bivalve aquaculture is considered to be one of the most sustainable, although some potentially negative environmental impacts arising from high deposition rates of faces and pseudofaces on the seabed have been identified. Habitat restoration management can be integrated within aquaculture practices to limit their negative impacts and it can bring positive environmental changes while obtaining both economical and cultural returns.This project aims to integrate restoration with aquaculture, namely the reintroduction of native flat Oyster reefs under mussels culture sites and harvest oyster spat recruiting as seeds in the original farm area to obtain economical returns and start a local oyster farming chain, while leaving the reef intact to provide ecosystem services. The main aim is to identify the best practices for this integration, in terms of size, stock densities and environmental conditions necessary to obtain maximum benefits in terms of both harvestable product and ecosystem services. This will be done combining modelling and experimental approaches, with a pilot site in the northern Adriatic sea. This approach will be included in the global environmental change scenario, and environmental optimals will be found where is possible to employ these strategies for maximum return in order to extend the theories beyond our study system. The results of this project will benefit mutiple stakeholders, from fishermen to policy to scientists working in similar areas. The outcomes will move forward the concept of integrating practices to obtain greatest sustainability without impeding economical advances. I aim to publish results in the form of scientific peer review articles and as a tool box guideline for best practices.

Keywords: restoration,reefs,molluscs
Unifying Control and Verification of Cyber-Physical Systems (UnCoVerCPS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: A new generation of components and systems: Engineering of advanced embedded and energy and resource efficient components and systems
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Germany,Germany,Spain,Germany,France,France,France,United Kingdom
Call: Smart Cyber-Physical Systems (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2019-02-28
Duration (months): 50.0
Total project cost (EUR): 4932902.75
EU funding (EUR): 4932902.25
Participants: 13
Project status: CLOSED

The proposed research effort provides methods for a faster and more efficient development process of safety- or operation-critical cyber-physical systems in (partially) unknown environments. Cyber-physical systems are very hard to control and verify because of the mix of discrete dynamics (originating from computing elements) and continuous dynamics (originating from physical elements). We present completely new methods for de-verticalisation of the development processes by a generic and holistic approach towards reliable cyber-physical systems development with formal guarantees. In order to guarantee that specifications are met in unknown environments and in unanticipated situations, we synthesise and verify controllers on-the-fly during system execution. This requires to unify control and verification approaches, which were previously considered separately by developers. For instance, each action of an automated car (e.g. lane change) is verified before execution, guaranteeing safety of the passengers. We will develop completely new methods, which are integrated in tools for modelling, control design, verification, and code generation that will leverage the development towards reliable and at the same time open cyber-physical systems. Our approach leverages future certification needs of open and critical cyber-physical systems. The impact of this project is far-reaching and long-term: UnCoVerCPS prepares the EU to be able to develop critical cyber-physical systems that can only be realised and certified when uncertainties in the environment are adequately considered. This is demonstrated by applying our ground-breaking methods to automated vehicles, human-robot collaborative manufacturing, and smart grids within a consortium that has a balanced participation of academic and industrial partners.

Keywords: hybrid systems,model predictive control,formal verification,conformance testing of models,automatic code generation,safety,automated vehicles,human robot collaborative manufacturing,smart grid
Development of new multi-valent vaccine systems against Candida pathogens (VacCan)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2023-08-14
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

The fungal pathogen Candida albicans is the most pathogenic of the Candida species and causes millions of superficial mucosal infections and approximately 200,000 deaths per annum due to invasive and disseminated disease in susceptible patient populations. Fungal infections in immunocompromised patients have an unacceptably high mortality rate of approximately 40%, and the yearly healthcare expenditure for the treatment of fungal diseases is estimated to be $15 billion. The clinical treatment of fungal diseases is hampered by poor and time-consuming diagnostics, a limited repertoire of anti-fungal drugs, and increasing levels of resistance to anti-fungal prophylaxis. Crucially, there are currently no licensed vaccines against fungal pathogen. Recent attempts to formulate vaccines have involved delivering simple mixtures of peptide/protein components of the target fungi with adjuvants (without controlled chemical conjugation), and without specific synthetic control have met with limited success. This project will develop new vaccine candidates to Candida albicans, the leading cause of fungal infection in humans worldwide. Unlike previous efforts, a multi-valent approach will be employed, chemically coupling three proteins expressed by Candida albicans. This synthetic approach will ensure the concurrent delivery of multiple protein antigens to overcome barriers faced by previous attempts at developing vaccines. Specifically, the project will focus on the synthesis of multi-valent systems by conjugating proteins to the surface of either: i) dendrimeric scaffolds (3D nanoscale covalent structures) or ii) liposomes (3D nanoscale self-assembled structures). This multidisciplinary proposal will use cutting-edge methodologies to address an unmet clinical need in fungal immunology that will deliver exceptional value through innovative vaccine research against fungal pathogens that are an escalating threat to global health.

Keywords: candida albicans,candidalysin,multi valent vaccine,evaluation in vivo,fungal infections,immune response,liposomes,self assembled structures,protein dendron,chemical biology
Localization in biomechanics and mechanobiology of aneurysms: Towards personalized medicine (BIOLOCHANICS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: France,France,France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-05-01
End date: 2020-12-31
Duration (months): 68.0
Total project cost (EUR): 1999396.0
EU funding (EUR): 1920003.0
Participants: 3
Project status: CLOSED

Rupture of Aortic Aneurysms (AA), which kills more than 30 000 persons every year in Europe and the USA, is a complex phenomenon that occurs when the wall stress exceeds the local strength of the aorta due to degraded properties of the tissue. The state of the art in AA biomechanics and mechanobiology reveals that major scientific challenges still have to be addressed to permit patient-specific computational predictions of AA rupture and enable localized repair of the structure with targeted pharmacologic treatment. A first challenge relates to ensuring an objective prediction of localized mechanisms preceding rupture. A second challenge relates to modelling the patient-specific evolutions of material properties leading to the localized mechanisms preceding rupture. Addressing these challenges is the aim of the BIOLOCHANICS proposal. We will take into account internal length-scales controlling localization mechanisms preceding AA rupture by implementing an enriched, also named nonlocal, continuum damage theory in the computational models of AA biomechanics and mechanobiology. We will also develop very advanced experiments, based on full-field optical measurements, aimed at characterizing localization mechanisms occurring in aortic tissues and at identifying local distributions of material properties at different stages of AA progression. A first in vivo application will be performed on genetic and pharmacological models of mice and rat AA. Eventually, a retrospective clinical study involving more than 100 patients at the Saint-Etienne University hospital will permit calibrating estimations of AA rupture risk thanks to our novel approaches and infuse them into future clinical practice. Through the achievements of BIOLOCHANICS, nonlocal mechanics will be possibly extended to other soft tissues for applications in orthopaedics, oncology, sport biomechanics, interventional surgery, human safety, cell biology, etc.

Keywords: biomechanics,aortic aneurism,rupture,full field optical measurement,inverse methods,distribution of material properties,nonlocal mechanics,soft tissues