Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Study of the role of mast cells in the modulation of immune and inflammatory responses associated with eczema: novel genetic approaches from mouse systems and relevance to the human disease. (MAST CELLS IN ECZEMA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2012-09-01
End date: 2015-08-31
Duration (months): 36.0
Total project cost (EUR): 256657.8
EU funding (EUR): 256657.8
Participants: 1
Project status: CLOSED

The overall objective of this grant is to complement Dr. Marichal’s expertise in basic and translational Allergy and Immunology. He will therefore integrate an outstanding laboratory in this area (Pr. Stephen J. Galli’s laboratory) at Stanford University School of Medicine, a world leader in medical education, training and research. Scientifically, Dr. Marichal will acquire cutting-edge knowledge in the detailed mechanistic understanding of allergic disorders, which are increasingly recognized as a major global public health problem. Indeed, the current proposal aims to evaluate in depth the contribution of mast cells in early immune and late inflammatory responses associated with skin eczema, the most complex allergic skin disorder. To address this question, two complementary genetic approaches of mast-cell deficient mice will be used in combination with a clinically relevant mouse model of skin eczema. In addition, Dr. Marichal will learn and take advantage of the innovative tool of Gene Set Enrichment Analysis to assess to relevance of the findings to the human disease. This challenging project is possible thanks to Dr. Marichal’s previous experience, in combination with the financial and technical resources of the host laboratory, as well as the scientific and training environment that will be provided. Pr. Galli has indeed a long history of highly successful training of postdoctoral researchers. Moreover, Dr. Marichal will benefit from many training and educational programs, enabling him to gain essential skills at the level of leadership, project management and financial independency and helping him in growing as an independent researcher. Finally, it is the goal of the outgoing and return host laboratories to create a strong international collaboration and a worldwide network of experts in the fields covered by the project, thereby addressing societal challenges and training needs at the worldwide scale.

Keywords: eczema/atopic dermatitis,mast cells,allergy/th2 response,cellular immunology,innate immunity,mouse models,microarray analysis,gene set enrichement analysis
Resolving short-distance physics mechanisms in hadron collisions at TeV-scale energies. (PROBE4TEVSCALE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-04-01
End date: 2014-03-31
Duration (months): 24.0
Total project cost (EUR): 191675.4
EU funding (EUR): 191675.4
Participants: 1
Project status: CLOSED

The Large Hadron Collider (LHC) at CERN offers a promising opportunity to discover and characterize a putative new physics sector at the TeV energy scale. Due to the complexity of the experimental signatures, the direct search for new particles at this huge experimental facility is a real challenge, requiring a very clear understanding of the structure of hadron collisions. For this reason, in the last decade a tremendous effort has been devoted to improving the accuracy of theoretical scattering amplitudes. Very recently, a new milestone has been reached with the elaboration of algorithms capable of generating hard scattering amplitudes at next-to-leading-order accuracy. In this context, it is urgent to redefine strategies for new physics searches at the LHC which makes maximum use of state-of-the-art theoretical information. In this project, we consider more specifically the case of decay chains, which plays a very important role in the search for new physics. As a first objective, we propose to use our expertise in Monte Carlo techniques, spin physics and next-to-leading-order calculations to develop a generic decay algorithm designed specifically to retain all spin correlation effects at next-to-leading order accuracy in any decay chain in the Standard Model and beyond, and to implement this algorithm in the MadGraph framework. Secondly, we propose to develop a matrix-element-based likelihood method dedicated to experimental analyses involving decay chains and constructed to maximize the use of spin correlation effects. Finally, we propose to revisit, with the aid of these tools, specific searches for new physics at the LHC -in particular the search for a light Standard Model Higgs- and to assess the increase of significance that is gained with a careful treatment of higher-order radiation and spin correlation effects.

Keywords: particle physics,quantum field theory,hadron colliders.
Graphene-Ferroelectric Interface for Electronic and Spintronic Technologies (GRAFIEST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-09-01
End date: 2015-03-01
Duration (months): 24.0
Total project cost (EUR): 224462.4
EU funding (EUR): 224462.4
Participants: 1
Project status: CLOSED

Graphene is a perfect infinite single layer of sp2-bonded carbon atoms densely packed into a benzene-ring structure. The confinement of electrons in two dimensions and the peculiar symmetry of the carbon network give graphene exceptional electronic properties that make it a promising material for carbon-based nanoelectronics and spintronics. In particular, the performances of such devices rely on the exceptional intrinsic carrier mobility of graphene. However, extrinsic scattering sources due to standard SiO2 substrates limit the mobility. Hence, the quest for alternative substrates is mandatory in order to increase the mobility beyond the extrinsic limits. Among the possible candidates, ferroelectric (FE) substrates are the most promising due to their ultrahigh dielectric constant and hysteretic dielectric response to an electric field (Objective 1). In addition, periodic polarization domains can be written in FE materials, resulting in a substrate with tunable periodic potential that would allow the engineering of the electronic properties of graphene without etching (Objective 2). Further, a magnetic FE (magnetoelectric, ME) substrate can induce magnetism in graphene and can transfer the ME properties to the graphene itself, hence allowing for electrical control of magnetism in graphene (Objective 3). The three Objectives of the present Proposal concern the theoretical investigation of these new hybrid graphene-FE and graphene-ME systems. Unveiling the properties of graphene-FE and graphene-ME interfaces is a fundamentally important first step towards the development of novel nanoelectronic and spintronic devices. In order to achieve the accuracy needed to capture the fine physical details and due to the nanoscopic scale of the systems to be studied, quantum-mechanical computations with atomic resolution are necessary. Hence, first-principles techniques based on Density Functional Theory (DFT) are the method chosen to address the proposed objectives.

Keywords: physical sciences,computational physics,condensed matter properties,nanoelectronics,spintronics,first-principles computation,graphene,ferroelectrics,multiferroics
Non adiabatic vibrational spectra from first principles. (NON ADIABATIC PHONON)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-04-11
End date: 2013-04-10
Duration (months): 12.0
Total project cost (EUR): 115773.6
EU funding (EUR): 115773.6
Participants: 1
Project status: CLOSED

We submit to consideration of the 7th framing EU program, Marie Curie Incoming Fellowship program, a research project in the field of computational material science to explore material thermal properties of homogeneous systems. We propose this project with the idea of setting up long term collaborations between the groups in Mexico and Germany. The proposed research program is aimed to understand, to develop and to characterize systems with novel properties originating from electronic correlations and in particular of systems where the electron-phonon coupling plays an important role in its thermal response. In that respect, we expect to use and implement two different recent proposed methodologies, which allow us to explore the non adiabatic contribution and anharmonic effects to the phonon spectra. This physical phenomena has been reported to have relevance in layered materials, such as graphene, MgB2, CaC6 and in most superconductor systems. Basically we will be implementing, within the ELK code(elk.sourceforge.net), two different methodologies to characterize thermal behavior away from the adiabatic approximation (a) a self consistent phonon calculation, where the atoms within the unit cell are displaced by a Bose-Einstein factor, such that they are able to reach a new stable minima as function of temperature (b) a fist order perburbation on the changes on the stationary forces after a time dependent perburbation on the ionic displacements is imposed into the system.

Keywords: physical sciences,computational material science,vibrational spectroscopies,thermal properties
Rapid evolutionary responses to climate change in natural populations: Integrating molecular genetics, climate predictions and demography into an eco-evolutionary modelling framework (RAPIDEVO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2013-01-01
End date: 2015-12-31
Duration (months): 36.0
Total project cost (EUR): 264639.6
EU funding (EUR): 264639.6
Participants: 1
Project status: CLOSED

Intensification and increased frequency of weather extremes is emerging as one of the most dramatic aspects of climate change. Thus, the study of ecological implications of global-scale changes is expanding from a focus on trends (e.g., mean temperatures) to broader investigations including the effects of extreme events and associated catastrophic disturbances (e.g., floods, fires, droughts). However, investigations exploring adaptations of individuals and species to altered patterns of extreme events are still rare and overarching studies are greatly needed. Crucially, rapid evolutionary and adaptative processes are highly relevant for understanding and predicting species responses to climate change. I propose to investigate the selective consequences of periodic catastrophic disturbances on genetic diversity and life-history traits, using marble trout (Salmo marmoratus) populations living in Slovenian streams as a model system. In this system, flash floods and debris flows causing massive fish mortalities are increasing in frequency and intensity. I will use an innovative multidisciplinary and interdisciplinary approach, combining (i) molecular genetics, (ii) demographic analysis and statistical characterization of temporal and spatial patterns of flood events, and (iii) life-history, demographic and eco-evolutionary modelling, to understand and predict the selective consequences of the altered pattern of catastrophic disturbances on the genetic composition and life-history traits of marble trout. Bringing together genetic, climatic, life-history and demographic aspects in this model system will allow the development of an overarching and general modelling and conservation framework for rapid evolutionary and adaptive processes, and will establish a reference of how to explore the consequences of climate change-induced intensification of weather extremes on natural populations.

Keywords: animal ecology,climate change impact,applied ecology,aquatic ecology
Controlling the Order of Functional Polymers and Their Corresponding Blends. (CONDPOLYBLENDORD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

Controlling the ordering of polymer systems has been the Holy Grail within the polymer community over the past 60 years. Researchers have used additives and processing variability to control the final properties of these commodity based polymer systems. One of the next generation, macromolecular materials - semiconducting polymers – presents new challenges since the functional properties (i.e. conductivity) of such systems are dependent on their molecular ordering. Furthermore, many functional polymer based devices (e.g. polymer solar cells) require complex, multicomponent and multi-layered systems. Thus, control of the micro-structure within these systems is of utmost importance for the successful development of the next generation polymer-based devices, which will be important, e.g., for the European Photovoltaic industry to remain competitive in a market which experiences a strong and increasing competition from companies in China, Taiwan or Korea. This proposal aims to use nucleating agents – dditives commonly utilized to manipulate the soldification of semicrystalline polyolefins – to control the ordering within conducting polymers and their corresponding blends. We will use this information to establish relevant structure-property interrelationships in these functional macromolecular structures, advance reliable processing protocols, and design the next generation of nucleating agents specifically for combination with conductive polymer materials.

Keywords: photovoltaics,molecular electronics,materials engineering,physical chemistry
Detection of exo-Planets via High-Accuracy Radial-velocity spectrographic measurements with Adaptive Optics enHancement (PHARAOH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-04-01
End date: 2015-03-31
Duration (months): 24.0
Total project cost (EUR): 157748.4
EU funding (EUR): 157748.4
Participants: 1
Project status: CLOSED

The PHARAOH project aims the detection of exo-Planets via High-Accuracy Radial-velocity spectrographic measurements with Adaptive Optics enHancement. The chief objective of this proposal is therefore to assess the impact of adaptive-optics (AO) correction on the detectability of Earth-like planets with a high-resolution, high-stability spectrograph on the future European Extremely Large Telescope (E-ELT). Since the discovery of planet 51 Peg b by M. Mayor and D. Queloz, huge progress has been made in the detection and characterisation of extra-solar planets. The increasing instrumental precision (in particular in the Doppler radial velocity (RV) domain) has raised the detection efficiency and allowed the scientific community to discover in 2004 the first ‘Neptune-mass planet’. The goal with the next generation spectrographs is to be able to detect rocky planets on current telescopes and Earth-like planets with the E-ELT. For that end an outstanding RV precision of 1 cm/s is required to detect the wobble of harbouring stars caused by a revolving planet. Embedding AO in actual instruments can further increase their precision in RV and their efficiency. For this fellowship, 3 work-packages were identified with scientific and management objectives: 1) AO simulations of the E-ELT, 2) impact of AO on spectrographic resolution and 3) implementation of instrumentation-directed activities at the host institute. All packages will be developed in strong collaboration with the exo-planet and instrumentation communities, in particular those with which the host presently partners internationally: the ESPRESSO spectrograph for the Very Large Telescope and ESA’s PLATO mission. Through a pondered choice of training and transfer-of-knowledge actions together with an exciting scientific project, the fellow will increase the prospect of gaining a mature position in state-of-the-art research and thereupon benefit the European Research Area.

Keywords: physical sciences
Thermochemical Storage of Solar Heat via Advanced Reactors/Heat exchangers based on Ceramic Foams (STOLARFOAM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-09-01
End date: 2014-08-31
Duration (months): 24.0
Total project cost (EUR): 224462.4
EU funding (EUR): 224462.4
Participants: 1
Project status: CLOSED

ThermoChemical Storage (TCS) involves the exploitation of the heat effects of reversible chemical reactions for the “storage” of solar heat. Among gas-solid reactions proposed for such an approach the utilization of a pair of redox reactions involving multivalent solid oxides has several inherent advantages that make it attractive for large-scale deployment. The new concept introduced in the current proposal is instead of using packed or fluidized beds of the redox material as the heat storage medium, to employ ceramic foam structures made entirely or partially from the redox oxide materials. In this respect the proposal involves an Experienced Researcher (applicant) who is a specialist in the synthesis of advanced oxide redox powder materials and in the shaping/manufacture of advanced porous ceramic structures for demanding applications, to be hosted in a world-class research institute (host organization) that is a solar simulator/furnace/tower facilities owner, specialized in the design and construction of high-temperature solar reactors. The main research training objectives for the applicant are related with the acquisition of hands-on experience with the design, operation and requirements of this variety of real concentrated solar power facilities and systems available at the host institution that will be used as test bench for pilot scale testing and validation of the project’s technological innovations . The proposed concept combines the demonstrated technologies of ceramic volumetric receivers and structured solar reactors with the inherent advantages of foam structures and promotes them one step further to the development of an integrated receiver/reactor/heat exchanger configuration with enhanced heat storage characteristics, through a series of innovations to be implemented concerning new reactor/heat exchanger designs, enhanced incorporation of redox materials in the reactor’s structure and improved redox material compositions.

Keywords: solar chemical reactors,thermochemical storage,redox materials,ceramic foams
Sources, transport, and degradation of permafrost-derived organic carbon in a warming Arctic: the Siberian Shelf (ARCTIC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-08-20
End date: 2014-08-19
Duration (months): 24.0
Total project cost (EUR): 181418.4
EU funding (EUR): 181418.4
Participants: 1
Project status: CLOSED

Among the mechanisms that could move significant quantities of green house gases into the atmosphere within this century, climate scientists are particularly concerned about the carbon (C) locked in permanently frozen Arctic ground that is now being released because of warming temperatures. Given the extent of this mega-pool of C (~1,400 Gt of C) susceptible to climate-induce changes compared to the atmospheric reservoir (~750 Gt of C), the potential release of this stock into the atmosphere due to thawing is considered a serious risk for the future climate. Recent studies suggest that a significant fraction of previously frozen soil will be re-located along the Arctic shelf. Indeed there are ample of evidence indicating that land-to-ocean fluxes of organic carbon (OC) along the Arctic coasts are changing because of thermal collapse of coastal permafrost and increase of the river runoff. However, the fate of this material once re-introduced in the marine carbon cycle is poorly constrained. With this project we propose to address this critical knowledge gap by analyzing the composition and physical properties of surface sediments from the Siberian Shelf. Our overarching objective is to develop and test a sensitive proxy of land-derived OC degradation in a system that will experience a massive supply of terrigenous material in the near future. The extent of degradation will be assessed using mineral surface-normalized concentrations of terrigenous OC. This latter will be characterized at molecular level using a suite of terrigenous biomarkers including lignin phenols, cutin-derived products, and high molecular weight compounds (n-alkanols, n-alkanoic acids and n-alkanes). The degree of soil-OC degradation will be assesses as a function of the depletion of the terrigenous biomarkers loadings relative to the original concentrations in river and permafrost samples. The study will be carried out on different sediment size fractions to avoid sorting bias.

Keywords: chemical oceanography,biogeochemistry,carbon cycle (climate change)