Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
LAND-use based MitigAtion for Resilient Climate pathways (LANDMARC)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Indonesia,Switzerland,Sweden,Colombia,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Canada,United Kingdom,United Kingdom,United Kingdom,Portugal
Call: Negative emissions and land-use based mitigation assessment (H2020-LC-CLA-2019-2, 2019)
Start date: 2020-07-01
End date: 2024-06-30
Duration (months): 48.0
Total project cost (EUR): 7062988.75
EU funding (EUR): 6999988.75
Participants: 20
Project status: SIGNED

Roughly 30% of Nationally Determined Contributions (NDCs) under the Paris Agreement (PA) include land-based mitigation measures, but there are still significant uncertainties in their effectiveness to deliver negative emissions. Aside from the expected shortfall of all current NDCs to deliver on the below 2 oC ambition, this uncertainty adds to the risks to human wellbeing as a result of climate change. Land-use based mitigation technologies (LMTs) can play a crucial role in the global efforts to meet the PA goals and the Sustainable Development Goals (SDGs). Considering the land-climate-development interface, LANDMARC aims to assess the impacts of LMTs as net sinks for greenhouse gas (GHGs) by applying unique mixed-methods approach. LANDMARC assesses the potential and feasibility of LMTs in the AFOLU sector by: a) quantitatively assessing environmental, social-economic, co-benefits and trade-offs identified through a suite of monitoring tools and model system (including land use, climate and economic models) complemented by; b) qualitative assessments guided by stakeholder engagement. This mixed-method approach allows us to provide more detailed insights on the effectiveness and climate resilience of LMTs at different spatial scales (e.g. scaling up from local/national level to the regional/global level). These tools, services and approaches will contribute to land-based LMT decision support in the private sector and by policy makers. LANDMARC is an interdisciplinary consortium with expertise from ecology, engineering, climate sciences, global carbon cycle, soil sciences, satellite earth observation sciences, agronomy, economics, social sciences, and business. There is a balanced representation of partners from academia, SMEs, and NGOs from the EU, Africa, Asia and the Americas, which ensures a wide coverage of LMTs operating in different contexts (e.g. climates, land-use practices, socio-economic etc.) and spatial scales.

Keywords: land management,agro forestry,beccs,land use modelling,macro econometric modelling,earth system models,in situ and satellite monitoring
Brick vaults and beyond: the transformation of a historical structural system (1830-1930) (BELVAU)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

Today, building vaults is no longer part of everyday building practice. However, for centuries vaults had been regarded as the ideal structure to span imposing spaces in cloisters, churches, cathedrals and palaces. Several studies have been devoted to the topic worldwide and cover the evolution of vaulting from Antiquity until its decline, typically situated around the 18th century. However, the introduction of new construction materials in the 19th and 20th centuries such as iron, steel and reinforced concrete, together with changing architectural styles and functional needs, growing structural insights and a better delineation of the role of building actors, ensures this later period is exciting to study. The aim of the BELVAU project is to study the evolution of vault construction in Belgium in the 19th and 20th centuries, taking into account the changing context of the young industrializing country. The study builds on my expertise of vaulting in earlier periods, as well as on the considerable research efforts recently undertaken to map the Belgian building sector in these two centuries. Vaults are fascinating study objects: they influence not only the aesthetics, but they are a basic element of the structural system. Consequently, the research questions focus on both aspects. What type of vaults were built during this period? Did these vaults follow traditional techniques? Which innovations were introduced? Did these innovations influence the aesthetical appearance? What are the specific features of Belgian vaults in relation with other European countries? What was the relation between the vault and the covered space? Who were the actors involved? How did the theoretical development of structural analysis influence the design and construction? Via literature study, archival research and in situ geometrical and structural analysis of several vaults, the project will contribute to improve the heritage value assessments of vaulted buildings from this period.

Keywords: construction history,architectural heritage,vaults,belgian architecture,19th and 20th centuries
Identifying Variable Chromatin Modules using single-cell epigenomics (CHROMISE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: SIGNED

Most common disease-associated genetic variants are thought to fall into gene regulatory regions, where they affect the interaction between transcription factors (TFs) and DNA and induce transcriptional changes. To understand the extent of, and the mechanisms underlying variation in binding of TFs to DNA, genome-wide TF and chromatin state profiling studies were performed which revealed that non-coding variants frequently mediate coordinated changes in TF binding and chromatin mark enrichment over regions that span more than 100 kb. These regions were termed “variable chromatin modules” (VCMs), providing a conceptual framework of how regulatory variation might shape complex traits. However, little is known about the formation, function, or plasticity of VCMs. This is because vast amounts of epigenomics data have so far been required for identifying VCMs, making their identification costly, labour-intensive, and only applicable to easy-to-culture cell types. Recent work has demonstrated the value of ATAC-seq for defining regulatory element hierarchies that conceptually resemble VCMs. Here, I propose to extend these principles by developing an experimental and computational workflow for VCM identification using single-cell ATAC-seq. This will allow sample multiplexing for sequencing followed by genotype-based demultiplexing, thereby increasing throughput, minimizing sample input, and mitigating variation between samples (Aim 1). I will apply this workflow to study VCM plasticity during human mesenchymal stromal cell differentiation (Aim 2). The resulting data will be used to identify VCM-linked metabolic disease-relevant genetic variants, whose role in VCM formation will be validated using CRISPR-Cas9 (Aim 3).
Late-stage C–H bond construction of cyclopropanes to impact drug discovery (LateCPC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

The cyclopropane ring is the 10th most commonly observed core in small-molecule drugs. This is due to the fact that cyclopropanes can positively influence metabolic stability, conformation, pKa, entropy, membrane permeability or pharmacokinetics in drug leads. The cyclopropane ring is often introduced in drug candidates at the early stages of the synthesis, however, the late-stage construction of multi-substituted cyclopropanes using C–H bonds as a functional group has not been developed yet. This concept promise to reach a “cyclopropanated” chemical space not possible by current strategies and that may impact how medicinal chemists will discover cyclopropane-based drugs that address unmet medical needs. LateCPC aims to develop an innovative technology to rapidly construct cyclopropanes from C–H bonds in feedstock and fine aromatic molecules as well as in complex drug molecules. Our approach will rely on the diazo activation of bespoke carbyne sources developed in the host group with metal catalysts, allowing the catalytic generation of metal-carbynoids. A key strength of this conceptually new and multidisciplinary proposal is the introduction of a secondment phase in Novartis (Basel) to explore real-life applications. The ambitious action merges perfectly the expertise of the host in novel C−H functionalization strategies based on the catalytic generation of innovative carbyne equivalents with the strong background of the applicant in metal-catalyzed Tsuji-Trost reactions, thus enhancing two-way transfer of knowledge between the ER and the host group. Successful development of this project will enable the ER to become a leader for the next generation in the field of chemical synthesis and late-stage functionalization techniques. The ER will be exposed to a wide range of cutting-edge chemistry and biomedical sciences in an interdisciplinary and international environment (ICIQ) that will aid the fellow’s competencies and cultivate him as independent researcher.

Keywords: rh carbenes,hypervalent iodine reagents,diazo compounds,cyclopropenes,cyclopropanes,cyclopropenyl cations
Marine Biodiversity as Sustainable Resource of Disease-Suppressive Microbes and Bioprotectants for Aquaculture and Crop Diseases (MARBLES)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Research and Innovation actions
Countries involved: Ireland,Germany,Germany,Spain,Ireland,Italy,Switzerland,Norway,Belgium,Netherlands,Netherlands,Denmark,United Kingdom
Call: Prospecting aquatic and terrestrial natural biological resources for biologically active compounds (H2020-FNR-2020-2, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 7496896.25
EU funding (EUR): 7496896.25
Participants: 14
Project status: SIGNED

MARBLES will use a novel and systematic approach to access and exploit marine microbial biodiversity for sustainable bioprospecting to discover microbial consortia and bioactive molecules for application in aqua- and agriculture and in the clinic. MARBLES' ecology-based bioprospecting strategy will focuses on unique host-microbe interactions in marine environments, including marine sponges, microalgae and fish, which rely on their microbiomes and microbial natural products for disease resistance. Partners’ existing microbial collections and new ones generated during MARBLES will be harnessed for the discovery of novel natural products and synthetic microbial communities. For this, MARBLES will use a systems-wide genomics approach to uncover the bioactive agents in disease-suppressive microbiomes. Also, MARBLES will explore host- and microbe-derived chemicals that elicit production of bioactive compounds, as elicitors to revitalise drug screening. The deliverables will be microbes and consortia and bioactive natural products, their derivatives and elicitors, which can be harnessed to fight infectious diseases in the agrochemical and aquaculture industries and in healthcare. Besides highly innovative, the approaches will be cost-effective and will offer advantages from both environmental and health perspectives in comparison to existing alternatives. The sustainable production of bioprotectants will increase the effectiveness of fish production - reducing the pressure on harvesting wild fish - and aid the transition of the crop agriculture sector towards bio-based and circular solutions. MARBLES will work closely together with a panel of SMEs and large companies from the EU aquaculture, crop protection biotechnology and health sectors. MARBLES fully complies with the Nagoya and Cartagena Protocols, and aims to make major contributions to the UN sustainable development goals, SDG 2, 3, 12, 13 and 14, as well as to current UN processes (BBNJ, DSI, SynBio)

Keywords: marine bioprospecting,disease suppression,microbiome,sustainable aquaculture and agriculture,chemical ecology,bioactive natural products,strain engineering,systems biology,healthy ecosystems
A Chemical Approach to Molecular Spin Qubits: Decoherence and Organisation of Rare Earth Single Ion Magnets (DECRESIM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-08-01
End date: 2021-01-31
Duration (months): 66.0
Total project cost (EUR): 1827375.0
EU funding (EUR): 1827375.0
Participants: 1
Project status: CLOSED

Coordination Chemistry and Molecular Magnetism are in an ideal position for the rational design of Single-Molecule Magnets which can be used as molecular spin qubits, the irreducible components of any quantum technology. Indeed, a major advantage of molecular spin qubits over other candidates stems from the power of Chemistry for a tailored and inexpensive synthesis of systems for their experimental study. In particular, the so-called Lanthanoid-based Single-Ion Magnets, which are currently the hottest topic in Molecular Magnetism, have the potential to be chemically designed, tuning both their single-molecule properties and their crystalline environment. This will allow the independent study of the different quantum processes that cause the loss of quantum information, collectively known as decoherence. The study of quantum decoherence processes in the solid state is necessary both to lay the foundations for next-generation quantum technologies and to answer some fundamental questions. The goals of this project are: #1 To unravel the mechanistic details of decoherence in molecular spin qubits based on mononuclear lanthanoid complexes. This study will stablish criteria for the rational design of single spin qubits. #2 To extend this study to the coupling between two or more spin qubits. This will allow us to explore the use of polynuclear lanthanoid complexes to achieve quantum gates or simple algorithms. #3 To extrapolate to infinite systems formed by the complex organization of spin qubits. This exploratory goal will permit us to move beyond zero-dimensional systems, thus facilitating the advance towards complex quantum functions.

Keywords: molecular magnetism
Superconductive MiR phOton Counter (ShaMROCk)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Quantum measurements based on single photon detectors (SPDs) can be efficiently carried out in the visible and near-infrared spectra due to the presence of two well-established technologies named silicon avalanche photodiodes and superconductive nanowire SPDs (SNSPDs). However, the mid-infrared (MIR) spectral range suffers from the absence of a fast SPD with high system detection efficiency (SDE) due to the lack of a competitive semiconductor technology or the poor absorption of the SNSPD systems showed so far. Vibrational modes of molecules and absorption bands of gases resides in this wavelength range, making a detector sensible to MIR single photons extremely sought for sensing and vibrational spectroscopy. Additionally, this wavelength range can be used efficiently for free-space QKD, being robust against adverse weather conditions. These are only but a few of the numerous applications that would benefit or be enabled by a performant SPD. The research goal of this proposal is to realize a Superconductive MiR phOton Counter (ShaMROCk) that outclasses all the existing technologies in terms of SDE, providing a solid platform for additional functionalities. SNSPDs realized so far suffered from the top-coupling approach that limits the interaction length between photons and the detector active area since the large diffraction limited mode of MIR light and the lack of MIR optical cavities. On the other side, in ShaMROCk I intend to integrate SNSPDs on top of MIR waveguides, realized using silicon carbide. All the light propagating inside the waveguide, evanescently coupled to the active are of the detector, can be absorbed in this way. The SDE is therefore limited by the efficiency with which light is coupled from a fiber to a waveguide. Preliminary results shows that ShaMROCk could provide a SDE twenty times higher than top-coupling SNSPD and two order of magnitude higher than other pursued technologies. This project will pave the way for MIR quantum measurements.

Keywords: waveguide single photon detector,mid infrared,silicon carbide
Harnessing Data and Technology for Journalism (JOLT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Ireland,Greece,France,France,Netherlands,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-05-01
End date: 2022-04-30
Duration (months): 48.0
Total project cost (EUR): 3912451.72
EU funding (EUR): 3912451.7199999997
Participants: 9
Project status: CLOSED

JOLT will deliver a world-class, multi-sectoral PhD research-training programme focused on harnessing digital and data technologies to advance economically sustainable and socially valuable journalism. Journalism is in profound crisis arising from declining advertising revenues, the dominance of US technology platforms, and the rise of online information-sharing including fake news. Journalism research has not kept pace with these changes. This is reflected in the lack of European, and indeed global, PhD programmes focussed on the intersections of journalism, data and technology. Europe lacks knowledge on the best-practice integration of data and digital technologies, strategies to overcome organization disruption, and on the political, social and ethical implications of digital journalism. JOLT addresses this lack by creating a multidisciplinary and multi-sectoral consortium of five leading European universities and twelve non-academic partners (four as beneficiaries) representing journalism NGOs, SMEs and large-scale media enterprises. JOLT’s training programme is grounded in the universities’ academic excellence and the complimentarily of diverse non-academic partners. In addition to secondments with non-academic partners, all ESRs will attend 3 industry workshops, 6 seminars on research and transferrable skills, and 3 summer schools, which draw on the cross-sectoral and multi-disciplinary expertise of all partners. JOLT’s key measurable outputs will be much-needed open-source tools and technical protocols, 30 journal articles, 30 conference papers, 15 policy and best-practice guidelines, and extensive media outreach conducted in collaboration with JOLT’s media partners. JOLT will act as a pilot for the formalization of similar PhD programmes, create a sustainable network of multi-disciplinary and cross-sectoral partners to advance research/innovation beyond the project, and support the renewal of a socially valuable and competitive European media sector.

Keywords: journalism,digital media,social media,politics,ethics and journalism,new technologies,digital media analytics,content based retrieval,visual content coding
Photon-recycling for high-efficiency energy harvesting in GaAs photovoltaic devices on silicon (RECHARGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-05
End date: 2020-06-04
Duration (months): 36.0
Total project cost (EUR): 248063.4
EU funding (EUR): 248063.4
Participants: 2
Project status: CLOSED

The Internet of Things promises billions of connected sensors and devices measuring and reporting information about the world around us. Due to the limited lifetime of batteries, this vision will not be realised without energy harvesting solutions providing power autonomy to sensors, a topic specifically prioritised in the 2016-2017 Work programme of Horizon 2020 (page 100). This project aims to develop and demonstrate high-efficiency and low-cost GaAs photovoltaic energy harvesters as power sources for wireless sensors, and equip the fellow with the entrepreneurial competencies required to commercialise the results. Prof. Tonio Buonassisi’s photovoltaic research lab at MIT (PVLab) is a global leader in optoelectronic modelling and testing of novel photovoltaic devices, and will train the candidate to determine the technical and economical viability of this new technology. The growth of these novel devices will be carried out with Mr. Brian Corbett in the III-V materials and devices group at the the Tyndall National Institute, Ireland. During the outgoing phase, as well as training in technical competencies, one-day a week will be dedicated to attending MIT’s Translational Fellows Programme, a specialist course for entrepreneurially-minded postdocs, teaching venture creation in-line with the candidate’s career goal to be an EU leader in science-based entrepreneurship in the clean energy sector. On return to the EU, a secondment at IQE plc., a III-V foundry, will allow the economic aspects of producing these devices in industry to be explored.

Keywords: energy harvesting,wireless sensor,photovoltaics,gaas,silicon