Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
In vitro evaluation of the biocompatibility of nanofibrous yarns from an oxidative stress perspective (BIOXYARN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Croatia
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-12-01
End date: 2017-11-30
Duration (months): 24.0
Total project cost (EUR): 170010.0
EU funding (EUR): 170010.0
Participants: 1
Project status: CLOSED

Fibres and textiles have been used as biomaterials for thousands of years, mainly as sutures and in dressings for wound care. Recently, it has become of increasing interest to use fibres as implantable materials to support the repair of damaged tissues and organs. In particular, the emergence of nanoscale electrospun fibres has allowed the fabrication of scaffolds that mimic the architecture of native biological tissues. Many studies have demonstrated that these biomimetic nanofibrous materials have the ability to promote cell adhesion, proliferation, and differentiation. However, mixed results have been observed in vivo with regards to their biological effects, including the inflammatory response. Therefore, there is a strong need to understand better the mechanisms involved in the cell response to nanofibres and to come up with better in vitro models for predicting the biocompatibility of electrospun materials in vivo. In tissue healing processes, oxidative stress has been identified as one of the key pathophysiological elements. Therefore, this project will evaluate the biocompatibility of electrospun yarns, a new and promising generation of electrospun materials, from an oxidative stress perspective. Human fibroblasts will be grown on the materials under standard and induced oxidative stress conditions. The cell response to the materials will be assessed, in particular in respect to the induction of 4-hydroxynonenal, a major bioactive marker of lipid peroxidation known as the "second messenger of free radicals". Particular attention will be given to the effects of material degradation and of added antioxidants on the onset of oxidative stress. This interdisciplinary project will contribute to understand the mechanisms underlying interactions between cells and nanofibres that occur upon implantation. Additionally, it will guide the development of electrospun yarns with improved biocompatibility and will aid to evaluate the risks associated to their implantation.

Keywords: oxidative stress,4 hydroxynonenal,redox signaling,growth control,healing promotion,electrospinning,nanofibres,advanced biomaterials,homeostasis,hormesis
Silicon based materials and new processing technologies for improved lithium-ion batteries (SINTBAT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Germany,Austria,Germany,Austria,Poland,Sweden,France,United Kingdom
Call: Extended in-service service of advanced functional materials in energy technologies (capture, conversion, storage and/or transmission of energy) (H2020-NMP-2015-two-stage, 2015)
Start date: 2016-03-01
End date: 2020-02-29
Duration (months): 48.0
Total project cost (EUR): 9755886.25
EU funding (EUR): 8334786.25
Participants: 9
Project status: CLOSED

According to the European Energy Storage Technology Development Roadmap towards 2030 (EASE/EERA) energy storage will be of the greatest importance for the European climate energy objectives. The Sintbat project aims at the development of a cheap energy efficient and effectively maintenance free lithium-ion based energy storage system offering in-service time of 20 to 25 years. Insights gained from advanced in-situ and in-operando analysis methods will be used for multi scale modelling targeting on the simulation of aging mechanisms for a reliable lifetime prediction and enhancement. In addition, the latest generation of anode materials based on silicon as well as a prelithiation process for lifetime enhancement will be implemented in the cell manufacturing process. The implementation of high energy materials combined with a low cost and environmental benign aqueous cathode manufacturing process will lead to remarkable cell costs reduction down to 130 € per kWh. This will enable battery based storage system for an economic reasonable price of less than 400 € per kWh (CAPEX) and will lower the OPEX down to less than 0.09 € per stored kWh for the targeted in-service time of 20 to 25 years (10,000 cycles). The technical developments will be supported by the set-up of a relevant roadmap as well as a catalogue for good practice. To guarantee the highest possible impact for the European economy the Sinbat consortium installed an Industrial Advisory Board including various European battery material suppliers, cell manufacturer and end-users whereby the whole value added chain in this way is completed within the Sintbat project. This strong interaction of the Sintbat consortium with relevant stakeholders in the European energy economy will assure that battery based energy storage systems are becoming an economic self-sustaining technology.

Keywords: lifetime,in service,aging,battery,lifecycle,monitoring,degradation,in situ analysis of aging mechanism,renewable energy,storage systems,lithium ion batteries,silicon based anodes,aqueous
Online and automated E. coli monitoring for 100% safe drinking water (ColiSense Online)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-07-01
End date: 2021-12-31
Duration (months): 30.0
Total project cost (EUR): 2413375.0
EU funding (EUR): 1689362.5
Participants: 1
Project status: CLOSED

Drinking water is the most essential resource for life. Access to safe drinking water can prevent disease outbreaks, and lower diarrheal and other disease burdens. According to the World Health Organisation around 330,000 cases of water-related disease such as E. coli are reported yearly in Europe. Just in 2016, 6,378 confirmed cases of Shiga toxin‐producing Escherichia coli infections were reported in the EU. Symptoms include diarrhoea, vomiting, stomach pains, nausea, headache, and fever. With the current technologies it can take two or more days to identify infectious risks in drinking water and by then the affected water is likely to have been consumed. ColiSense will bring to industrial production stage a quick (60 min), inexpensive (€1 per analysis) and accurate analyzer capable of detecting and quantifying E. coli cells in drinking water below the regulation threshold limits (1 cell per /100ml). ColiSense can be applied in a wide variety of industries, including the ones with the highest quality water demands in Europe (e.g. waterworks, food and beverage, pharma, cosmetic, etc.), and reach very high levels of efficiency. Our solution makes monitoring low-cost and easy to use with an enabled cloud dashboard (for remote monitoring) and analytic tools. The ultimate goal of ColiSense is to eliminate the large problem of E. coli contaminated drinking water distribution in EU (preventing people becoming sick by preventing them from drinking contaminated water). bNovate Technologies AG (bNovate) is a company that offers solutions to waterworks and food and beverage industries for automated monitoring of microbiological parameters and fast detection of bacterial contaminations in water. The bNovate staff is composed of experts and professionals who have extensive knowledge in a wide variety of subjects related to water science, microbiology and flow cytometry.

Keywords: water safety,water monitoring,e coli,drinking water,microbiological analysis
Electric Propulsion System for the Air Transportation of Tomorrow (EPS55)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-03-01
End date: 2019-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

H55 SA is a Swiss company created in 2017 by three members of the Solar Impulse Project, the first round-the-world solar flight. With the strategy of offering electric propulsion solutions to aircraft manufacturers, with systems safety review leading to airplane certification ready, H55 has dedicated the last year and a half to the development of its EPS55 patented technology: The Electric Propulsion System for the Air Transportation of Tomorrow. EPS55 is a ground-breaking and cost-effective Electric Propulsion System (EPS) for Very Light Aircrafts (VLA) and Vertical Take-off and Landing (VTOL) with a certifiable Battery Management System able to handle multiple battery systems, electric motors, hybrid systems and do so while setting priorities in an organized hierarchical way. EPS55 has already proven its feasibility with the integration of a first prototype in an acrobatic aircraft in 2017 which achieved performance values far ahead any of its EPS competitors: 1 hour flight time with 40% of battery reserves at a direct costs per hour of only 18€. Electrifying aviation market is a real and urgent need to achieve noise and green-house emissions reduction of the sector, which reached 768 million tonnes of CO2 in 2016. In addition, safety is a major issue and reducing the human failure factors, which account for the largest reason of air accident fatalities among light aircrafts, is a must. Regarding costs, electrifying light aircraft industry will be market feasible only if final operational costs are approximate to other means of transport like vehicles. Electric aircraft market has a huge potential: it is projected to grow from 6.61€ Billion in 2018 to 9.27€ Billion by 2021, at a CAGR of 7.33% and is predicted to keep growing at a CAGR over 4% after 2021. EPS55 will reach this market by 2021 and will enable the next necessary step for electric aviation to become a reality.

Keywords: electric aviation,propulsion system,battery management
Safe and fast control system for acrylamide in food (AFREELAMIDE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Acrylamide is a human neurotoxin classified as a probable carcinogen. It is present in heat-processed foods high in carbohydrate, such as snack foods, potato crisps, breads, cereal products, and coffee. Therefore acrylamide is considered a public health risk. Since April 2018, a new EU directive has entered into force, which urges food operators to monitor the presence of acrylamide in foodstuffs. However, existing acrylamide detection techniques rely on time-consuming, expensive and complex assays that are only conducted to a few samples of products in the laboratory. Our INNOVATION provides a non-invasive, rapid, robust, accurate and 5x cheaper inspection system adapted for at-line and real-time monitoring. AFREELAMIDE is a detection device that uses near-infrared spectroscopy (NIRS) technology to efficiently inspect food piece one by one and detect acrylamide. The PROTOTYPE is currently at TRL6 and we intend to conduct several assessments under the umbrella of the SMEI Phase-1 project, before moving further. These will include experimental trials with an industrial operator (Siro Group), among others. The AFREELAMIDE solution will be marketed by local, national and international distributors (including online distribution) with a consolidated network and experience, which are paid out commissions. Estimated Unit selling price AFREELAMIDE: 20.000€. According to financial assumptions, sales will reach more than 8 million € by 2025 with 11 employees.

Keywords: acrylamide,food safety,process control,food,bread,potatoes,coffee,cereals,substances harmful,to health,carcinogenic substances
Sympathetic Wiring of Adipose Tissue (CLEARFAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Obesity is a metabolic disorder with unmet medical intervention strategies, for which a therapy is urgently needed. The Domingos Lab recently discovered that sympathetic (SNS) neuro-adipose junctions mediate lipolysis and fat mass reduction (Zeng et al., 2015). Thus, direct and targeted activation of SNS inputs to adipose tissues (AT) could represent a new strategy for the induction of fat loss that would circumvent central leptin resistance as well as historical challenges associated with drug delivery across the blood-brain-barrier. While it is known that the autonomic nervous system (ANS) plays a critical role in energetic metabolism through both its sympathetic and parasympathetic (PNS) branches; the mechanisms that underlie the development of the autonomic innervation of AT remain completely unexplored. Both the parasympathetic and sympathetic systems develop before birth, and autonomic nerve fibers can be observed in various peripheral organs as early as mid-gestation (Black, 1978; Burris and Hebrok, 2007; Rinaman and Levitt, 1993) although as AT originates at late gestation it is unclear how this late stage targeting may occur and how disruption to this process may impact metabolic profiles later in life. Although it has recently gained acceptance as an important endocrine organ, the cellular architecture of AT also remains elusive, as well as how this may be altered past hyperplasia and hypertrophy in pathological states. This has been due to the amorphous and unclearly defined nature of the tissue that becomes deformed and disrupted by classical dissection. The advent of whole body tissue clearing techniques allows us for the first time to study the architecture of AT and its inputs obviating the need for dissection and sectioning.

Keywords: metabolism,sympathetic nervous system,development,obesity
Laser Dismantling Environmental and Safety Assessment (LD-SAFE)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Decommissioning and environmental remediation
Action type: Innovation actions
Countries involved: Spain,Belgium,Sweden,France,France,France
Call: Fostering innovation in decommissioning of nuclear facilities (NFRP-2019-2020, 2019)
Start date: 2020-07-01
End date: 2024-06-30
Duration (months): 48.0
Total project cost (EUR): 4044689.0
EU funding (EUR): 2799112.1
Participants: 8
Project status: SIGNED

The aim of NFRP-2019-2020-09 call is to capitalise existing technologies for characterisation and risk assessment, dismantling, on-site waste management and environmental remediation in order to gain needed efficiencies in the decommissioning of nuclear power reactors. One very challenging dismantling task in the focus of the industry is the segmentation of the reactor pressure vessel and internals. Limitations are known for all conventional cutting techniques currently used including mechanical cutting, plasma arc cutting or abrasive water jet cutting. In this context, the laser cutting technology for nuclear dismantling, an adaptation from the manufacturing industry developed by over a decade of R&D efforts, is identified in Europe and elsewhere in the world as a promising alternative. The objective of the LD-SAFE project is to validate the laser cutting technology for the dismantling of the most challenging components of power nuclear reactors in air and underwater. LD-SAFE project will remove the last barriers to enable the replacement of conventional cutting techniques and prove by 4 specific objectives that the technology is mature (TRL7): - Objectives 1: Demonstration of the capabilities of a versatile laser cutting solution to address the key technical challenges in decommissioning of large nuclear facilities - Objectives 2: Environmental and safety assessment of the implementation of laser cutting for nuclear reactor decommissioning - Objectives 3: Technical validation of the laser cutting prototype in operational environment (TRL7) - Objectives 4: Demonstration of the economic advantage of using the laser cutting technology for the forthcoming reactor decommissioning market LD-SAFE consortium is a strong partnership of 4 leading industrials and 2 European research centres having extensive track-records in the field of dismantling of nuclear facilities; environment and people protection; safety assessment; and associated domains.

Keywords: decommissioning,dismantling,reactor,pressure vessel,internals,laser,cutting,in air,underwater,safety,environment,assessment,qualification,prototype,demonstrator,economic,time,market
Optimised Electric Network Architectures and Systems for More-Electric Aircraft (ORCHESTRA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Italy,Austria,Germany,Italy,Spain,Italy,France,France,United Kingdom,United Kingdom
Call: Innovative electric network architectures and systems, optimising global energy, electrical power, data and communication for aviation (H2020-MG-2020-SingleStage-INEA, 2020)
Start date: 2021-02-01
End date: 2025-01-31
Duration (months): 48.0
Total project cost (EUR): 4829335.0
EU funding (EUR): 4829335.0
Participants: 11
Project status: SIGNED

ORCHESTRA combines: · The leading University in Europe (UNOTT) on Aircraft electrification, · Europe’s leading Regional Aircraft Company (LDO VEL), · The world largest provider of aircraft Systems (SAF & SEP), · Leading experts on Thermal Management (CIRA&FhG) and Electrical Energy Storage Technologies (AIT), · Innovative businesses specialising in technologies for Aircraft Electrification (SKLE, BSIM &AER) · Leading experts with decades of experience in aircraft certification (VR-ASP) to deliver the “Technological Building Blocks” (TBB) that will form the foundation for the development of Much More Electric Aircraft (M2EA). The key quantitative objectives achieved by ORCHESTRA will include overall EPS weight reduction by 25% and improvement in EPS efficiency by 10% compared to the current state-of-the-art. The ORCHESTRA consortium will investigate all the relevant technical aspects including electrical architectures, machines, power management and control, harness solutions, thermal management, electric energy storage, experimental and virtual testing, as well as systems integration, to develop and deliver a holistic framework of innovative modular scalable “building blocks” that incorporate emerging technologies and breakthrough design ideas. Each partner within the Consortium has been carefully selected due to their world leading expertise in the technology areas indicated Figure 3. The involvement of VR-ASP, with decades of experience on aircraft certification, is noteworthy to ensure that TBBs delivered through ORCHESTRA will be designed with a clear path to certification from the outset. This will be complemented through the involvement of EASA on the Industrial Advisory Board.

Keywords: aerospace electrification,electrical networks,electrical architectures,power electronics,electrical machines
Neurotechnology to understand the emotions of customers in market research (usenns)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2014-09-01
End date: 2014-11-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Human-Centric Marketing is the current trend in marketing that looks at customers holistically, recognizing their emotions as one of the most important dimensions. All experts indicate that only the companies that adapt to this trend will successfully survive the current competitive and global environment. However, traditional market methodologies cannot objectively measure emotional insights as this information is unconscious and cannot be accessed under rational processes. BitBrain has already developed a neurotechnology solution able to measure emotions completely adapted to the market research sector, and the objective of the usenns project is to penetrate the market. This solution has 3 main innovations: i) two new measurement devices (neuroheadset and a “ring”) adapted to the market research sector; ii) the encapsulation and integration within the technology of all the neuroscience knowledge on design-execution of experiments and on elaborated data analysis, in a completely transparent manner for the user; and iii) presentation of the results on emotions of consumers in a comprehensible and valuable language for the market researcher and its client. This results in a technology easy to implement in market research companies without incurring a risk due to high initial investments (clients pay an affordable price for the measurement devices), and a pay-per-use with a reasonable price only charged at the end of a study. This pay-per-use service with a visualization and interaction web-based application make this business model highly scalable. The objectives of the feasibility project are to accelerate the process of corroborating the business plan, and to define an action plan to reach mainstream commercial use from the current prototype state. After the feasibility study, the action plan will bring to the market a solution that will revolutionize the global market research sector by helping companies to design better strategies adapted to their customers

Keywords: neurotechnology,market research