Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Validation of Progranulin as Biomarker in Diagnostics and Prognosis of Sepsis (Vaprosep)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Germany
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Sepsis is a complex, systemic and inflammatory host reaction on an infection and with worldwide 1.5 million cases per year a health challenge. There is a strong need for a reliable biomarker like progranulin. Preliminary data prove that progranulin allows a highly sensitive and specific detection of sepsis, a monitoring of infection without time delay, prognosis regarding disease course and a differentiation between the infectious agent inducing sepsis. Economic advantages of progranulin as biomarker are the reduction of the length of stay in the ICU (500-1000€ / day) and avoidance of unnecessary antibiotic therapy (10-500€ / day). Thus, the hospital can improve patient care and reduce therapeutic costs by a progranulin measurement for 5-10€. A mean incidence rate of 0.094% results in a 12 million euro market in the US and EU. Based on intellectual property this market is available only for Mediagnost. Successfully validated, progranulin measurement will be introduced in third level hospitals in the EU. The subsequent strategic product development includes point of care and multiplex test systems. Mediagnost already has a technically validated test system for this biomarker available, therefore the overall objectives of this study are the clinical validation of progranulin measurement in sepsis and its implementation in clinical routine. Specifically, in phase I the economic potential of this biomarker is evaluated. These objectives are addressed during phase I in a feasibility study including market and cost analysis. Key opinion leaders in the EU are interviewed by a structured questionnaire to evaluate scientific solidity and market potential. In direct contact to EU Notified Bodies the best regulatory strategy is evaluated. Further, literature research will complete the picture of the market and reimbursement requirements. Excellent infrastructure and highly qualified scientific and administrative employees guarantee the successful completion of this work.

Keywords: sepsis,monitoring,diagnosis
European Training Network for Cell-based Regenerative Medicine (Training4CRM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Spain,Italy,Germany,Italy,Norway,Sweden,Sweden,Sweden,United States,Netherlands,Denmark,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2016-11-01
End date: 2020-10-31
Duration (months): 48.0
Total project cost (EUR): 4028783.4
EU funding (EUR): 4028783.4
Participants: 15
Project status: CLOSED

The main objective of Training4CRM is to train a new generation of 15 highly inter-disciplinary early stage researchers at the highest international level and quality, who will be immediately employable in both the academic and industrial sectors due to their highly sought after cross- and interdisciplinary insights and expertise. Training4CRM addresses existing gaps within Cell-based Regenerative Medicine for treatment of neurodegenerative disorders (e.g. Parkinson´s, Huntington´s, Epilepsy), which occur as a result of progressive loss of structure, function and/or death of neurons in the brain. The disorders have a high prevalence and are associated with impairments and disabilities with high emotional, financial and social burden. New scientific discoveries and technologies are needed, and Training4CRM sets out with the ambition to educate and train students within and across different scientific disciplines to be able to master the design, fabrication and testing of completely new tools and materials within the fields of: Micro- and Nanoengineering (nano/microstructures, 3D scaffolds and 3D lab-on-a-chip devices of different materials, geometries, architectures and properties, wireless electronic components; Biotechnology (human stem cells, human induced pluripotent stem cells, optogenetics, tissue engineering; Pre-clinical studies for the purpose of investigating in vivo, in experimental animals, how the developed cells, materials, structures affect the animal at the physiological and behavioral levels, unravelling the therapeutic effects of the developed strategies.

Keywords: waveguides,artificial tissue and organs,lab on a chip,parkinson s,huntington s,epilepsy,conducting scaffolds
Mobility and management of cattle in Iron Age and Roman Netherlands (MoMa)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This research project aims to study long-term developments in cattle management and mobility in the Netherlands, from the Iron Age to the Roman period (750 BC – AD 450). Cattle have always played a crucial role in this region, in supporting arable farming by traction and manure, in providing food in the form of meat and dairy products, and in providing raw materials for clothing and artefacts. Our understanding of cattle management could be improved enormously by an integrated study of traditional and newer methods of research. The main objectives of the research project are: • to investigate movements of cattle in the Iron Age, indicating exchange and/or raiding; • to investigate movements of cattle in the Roman period, indicating import and/or local supply; • to investigate whether the size increase of cattle in the Roman period was a direct result of the incorporation in the Empire, or whether it should be seen as a continuation of developments that started in the Iron Age; • to provide a comprehensive view of cattle management in the Iron Age and Roman period. The objectives will be achieved through the applied methodology, which consists of three lines. First, through Strontium isotope analysis, the local or non-local origin of cattle can be established. Second, biometrical analysis will be used to investigate developments in shape and size over time. And third, mortality profiles offer insight into how cattle were exploited. Two work packages correlate to the first two methods, while the third combines the results from the other work packages with mortality data to obtain a comprehensive view of cattle management. A fourth work package is concerned with dissemination of the results among an academic and non-academic audience, while the fifth covers training in statistics and transferable skills. The project will provide the applicant with specific research skills (stable isotope analysis, biometrical analysis) that are still underused in the Netherlands.

Keywords: zooarchaeology,animal husbandry,netherlands,iron age,roman period,cattle,mobility
Empowering Patients by Professional Stress Avoidance and Recovery Services (STARS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Pre-Commercial Procurement
Countries involved: Spain,Germany,Italy,Spain,Italy,Finland,Greece,Netherlands
Call: PCP - eHealth innovation in empowering the patient (H2020-SC1-2016-CNECT, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 4657000.0
EU funding (EUR): 4191300.0
Participants: 11
Project status: CLOSED

Patient Empowerment Individualized tackling of unnecessary stress, in particular when related to healthcare procedures, promises to enhance the autonomy and quality of life of many people and yield a significant contribution to self-empowerment, thus relieving careers and related persons from personal assistance. Not at least, also a considerable economic relief (see Impact). This is the topic the STARS consortium is determined to deal with. Of course, as will be shown, the objective is complex and ambitious and has to meet challenges from smart vital signs measuring to wireless real-time transfer of large data amounts to big data management. Nevertheless, concerning the expectable positive impact there is a large potential of revenue for the efforts. And, regarding present technological progress, it seems absolutely feasible to face this challenge when doing this inby a concerted, multidisciplinary, cross-linked effort. To achieve the aim, our proposal addresses an advanced, eHealth based concept for tailored avoidance and/or reduction of healthcare related stress, beginning as early as in the preclinical phase, proceeding during their hospitalisation until the end of the aftercare period. I.a. it can be expected that, recovery time will be shortened, harmful side-effects of sedating drugs will be prevented and costs will be reduced, which in sum will be an important contribution to a cost-effective healthcare system in the next decades.

Keywords: patient empowerment,hospitalised,outpatient,continuum,ehealth,mhealth,self management tools,open innovation,more cost effective,transition to new services,increase role of responsibility of
Effects of atmospheric DUST deposition on COccolithophore production (DUSTCO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 148635.6
EU funding (EUR): 148635.6
Participants: 1
Project status: CLOSED

The deposition of atmospheric dust is thought to provide nutrients that are essential for phytoplankton growth in large areas of the ocean, with implications for primary production and remaining oceanic food chain, as well as for the ocean's biological carbon pump. Amongst the main primary producers in open-ocean oligotrophic waters are the coccolithophores. By also including more opportunistic taxa that quickly respond to short-term changes linked to nutrient input, and by being both photosynthetic and calcifying, coccolithophores provide interesting perspectives as indicators of ocean fertilization by dust, and its contribution to the organic and inorganic oceanic carbon pumps. Given the huge amounts of Saharan-dust blown into and over the equatorial North Atlantic, a region where nitrogen fixation is co-limited by Fe and P, it is only likely to expect that dust will act as nutrient supplier for marine phytoplankton. Here, I propose to investigate the effects of Saharan dust deposition on the cell production, species composition, carbonate production and coccolith-Sr/Ca ratios on coccolithophore populations across the equatorial North Atlantic. The study will be based on seawater samples covering the entire photic layer and sediment trap samples collected between NW Africa and the Caribbean, complemented by a coccolithophore culturing exploring the response of key coccolithophore species to dust input. As the transatlantic array was lying directly underneath the largest dust plume originating from the African continent (12º N), and two events of dust deposition were clearly recorded during the sampling cruise, DUSTCO provides a unique in situ opportunity to investigate the potential of Saharan dust as a fertilizer. Ongoing multidisciplinary research in the region, offers an excellent context for this study. The obtained findings will be used to develop a dust-related coccolithophore-based correlation/calibration function.

Keywords: coccolithophores,coccolith caco3,coccolith sr,batch culture,phytoplankton pigments,saharan dust,amazon river,tropical north atlantic
Low-cost and low-maintenance innovative mid-power horizontal axis wind turbine operable with low winds and small installation areas. (INNOWIND)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Sistema Eólico Morcillo is a Spanish SME specialized in the development, construction and sales of innovative medium power wind turbine systems. We have developed and patented a disruptive multi-award winning wind turbine technology called INNOWIND. By 2050, the EU-28 aims to achieve CO2 emissions cuts of 80-95% compared to 1990 levels and to achieve a 20% share for renewable energy sources in its overall energy consumption by 2020. This requires a process of "decarbonising" Europe's economy, including the development and deployment of low-carbon technologies. Wind energy and Solar photovoltaic (PV) energy have been the leading sources of low carbon electricity generation in EU since 2011. The installation of wind turbines is characterized by very high construction costs that amortize slowly over the years through the sale of electricity to the grid. The amount of energy produced depends mainly on the nominal power of the installed generator and of the amount of wind that can be used. INNOWIND offers cost-effective mid-power wind turbine farms, with high flexibility in terms of size and area of construction, with low security requirements and no special construction permits required, making implementation in urban areas a possibility. INNOWIND offers for the first time the opportunity to make use of terrain not suitable for conventional wind farming. Furthermore, thanks to the easy scaling of the units from 50kW to 1000kW, it is possible to cater the specific power needs in a wider range of use-cases and scenarios. Other unique selling points include less visual and environmental impacts, safer in case of storm or fire damage,

Keywords: wind turbine,electricity,mid power generator,low wind speed,low cost,low maintenance,environmental impact,small construction area,horizontal axis
Maintaining Quantum Coherence for Quantum Information Applications (MQC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Quantum information technologies have attracted much attention in recent years. Advanced fabrication technologies have made it possible to develop quantum architectures, such as trapped ions, color-defects in crystals (nitrogen-vacancy in diamond), and Rydberg atoms, where quantum information applications can be implemented. At the heart of this growing field stands quantum coherence. Maintaining coherence for longer times enables the realization of richer and more interesting quantum applications, varying from quantum gates for quantum computation, through quantum simulation of classical intractable systems, to quantum sensing schemes for medical applications. Noise, leakage and decay channels constitute the main sources for decoherence, which limit the fidelity of the desired quantum operations. In this project my main goal is to theoretically investigate ways to maintain coherence in the quantum systems mentioned above, while realizing a variety of quantum applications. This will be done using either dynamical decoupling or quantum error correction techniques. A numerical verification of the theoretical proposals will be undertaken using Runge-Kutta simulations of the systems together with the Orenstein-Uhlenbeck noise process. Importantly, I intend to collaborate on the realization of the theoretical proposals with the relevant experimental groups. In this way, I will enrich my scientific knowledge regarding the specific decoherence sources in the different experimental setups, and thus, my theoretical investigation can be adjusted specifically to the experimental needs. Eventually, these experiment-theory collaborations will end up in experimental verification and application of the theoretical proposals, which will have high impact on research within and far beyond physics.
Drug release metadynamics simulations with natural micro- and nanostructured excipients (METADRUG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

Finding the most efficient and cheapest drug-excipient complex for an increased or modified release kinetics profile of drugs in the body is a current technological challenge in the pharmaceutical industry, especially to improve the treatment of high prevalence and third-country diseases. In this context, it is highly interesting the research on adsorption and diffusion of organic compounds in the surface or internal spaces of clays or related systems. The aim of this proposal is to apply the unique enhanced sampling metadynamics computational tool to properly analyse the processes involved at the nanometric scale, leading not only to rational principles but also to predictions of the pharmaceutical properties. Initially, a computational strategy based on metadynamics simulations will be defined to reproduce known drug release kinetics in drug-clay complexes. A program to automatize all the computations and data management (METADRUG) will be developed after that and in a subsequent step it will be applied to predict unknown release kinetics of relevant drugs from laminar, porous and nanotubular clays. The overall results shall allow determining the clay structural parameters and drug-clay interactions which modulate the release energetics, contributing to the development of new drug delivery systems and novel analysis processed in pharmaceutical technology. The comprehension and accurate prediction of drug increased or modified release phenomena will contribute in this manner to the EU to gain a competitive edge in this area. By means of the proposed project, the fellow will reach a great expertise in the field of Theoretical and Computational Chemistry by strengthening her skills in the use of classical and quantum chemistry methods, acquiring experience with the employment of metadynamics approaches, and learning about programming in Lammps and Plumed. The fellowship will also allow the applicant to develop a promising scientific career to the European level.

Keywords: metadynamics,clay minerals,antiparasitic,antimicrobial and antidiabetic drugs,schistosomiasis,tuberculosis,diabetes,drug release,pharmaceutical technology,force fields
Underwater Time Of Flight Image Acquisition system (UTOFIA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Norway,France,Denmark,United Kingdom
Call: Acoustic and imaging technologies (H2020-BG-2014-2, 2014)
Start date: 2015-02-01
End date: 2018-04-30
Duration (months): 39.0
Total project cost (EUR): 5716971.0
EU funding (EUR): 5716971.0
Participants: 8
Project status: CLOSED

UTOFIA will offer a compact and cost-effective underwater imaging system for turbid environments. Using range-gated imaging, the system will extend the imaging range by factor 2 to 3 over conventional imaging systems, while at the same time providing video-rate 3D information. This will fill the current gap between short-range, high-resolution conventional video and long-range low-resolution sonar systems. UTOFIA offers a new modus operandi for the main targeted domains of application: marine life monitoring, harbour and ocean litter detection, fisheries and aquaculture stock assessment, and seabed mapping.

Keywords: underwater imaging,time of flight,backscatter reduction,range gated imaging
Assessing safety of food packaging through computational toxicology (SafePack)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-03-16
End date: 2020-08-19
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 2
Project status: CLOSED

Thousands of chemicals contained in food packaging may potentially migrate into foods and result in consumer exposure. There is an increasing alarm about their potential toxicological effects since most of them lack data, while others (e.g. bisphenol A) have created significant debate because of their documented endocrine properties. This project, SafePack, aims to offer a publicly usable in silico strategy to establish rapidly and cost-efficiently the level of safety concern of packaging chemicals without animal toxicity testing. There has been already initiatives to screen packaging chemicals using in silico toxicology, but all of them use qualitative approaches, mainly mutagenicity predictions, suitable for hazard identification. However they do not provide information about hazard characterization (how much is needed for triggering a toxic effect) and even less about health risks. In toxicology, "the dose makes the poisons" and it is very important to address safety concern by balancing predicted toxicological alert with potential exposure as done in standard risk assessment. The SafePack project aims at a) fill the toxicological data gaps of large sets of packaging chemicals using computational tools to predict toxicities, b) compare predicted toxicological values with exposure to obtain Margins of Exposure (MoE), a powerful method to establish level of safety concern, c) implement the overall workflow in freely available VEGA platform to make it ready for free utilization. Thousands packaging chemicals will be compiled. A number of toxicity endpoints relevant for risk assessment will be sequentially screened using available in silico predictive models: mutagenicity, carcinogenic potency and chronic toxicity; also, endocrine activity and developmental toxicity will be covered. The quantitative predicted values will be compared to exposure estimates providing MoEs, the size of which determines the level of safety concern.

Keywords: in silico models,food packaging,exposure,mutagenicity,endocrine disruption,developmental toxicity,carcinogenicity potency,chronic toxicity,safety assessment,qsar,read across