Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Infradev - European Paediatric Translational Research Infrastructure (ID-EPTRI)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Italy,Albania,Germany,Estonia,Italy,Israel,Spain,Austria,Spain,Italy,Italy,Italy,Ukraine,Cyprus,Switzerland,Belgium,Russian Federation,Sweden,Greece,Hungary,Poland,Romania,France,Czechia,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Design Studies (H2020-INFRADEV-2017-1, 2017)
Start date: 2018-01-01
End date: 2020-04-30
Duration (months): 28.0
Total project cost (EUR): 3071250.0
EU funding (EUR): 3000000.0
Participants: 32
Project status: CLOSED

The general objective of this project is to design the framework for the European Paediatric Translational Research Infrastructure (EPTRI), a new Research Infrastructure (RI) aimed to enhance technology-driven paediatric research in discovery and early development phases to be translated into clinical research and paediatric use of medicines. The starting point of the proposal is the serious lack of medicines for children in EU and worldwide as well as the lack of a developmental model for paediatric medicines that integrates technology-driven aspects with the methodological, ethical and regulatory framework. The design for this new RI will be based on the following main pillars: • to harness efficiency and delivery of paediatric research activities and services strengthening collaboration within the scientific paediatric community; • to be a complementary RI in the context of the existing RIs covering the current gaps, while avoiding any duplication; • to develop a one-stop-shop for advice in paediatric drug development. To prepare a valuable Conceptual Design Report (CDR), the project encompasses three phases. During the Context Analysis phase, that will be performed in 5 technical and scientific domains (1- Paediatric Medicines Discovery, 2- Paediatric Biomarkers and Biosamples, 3-Developmental Pharmacology, 4-Paediatric Medicines Formulations and Medical Devices, 5- Underpinning Medicines Development to Paediatric Clinical Studies) the perceived value and the possible gaps to be covered will be estimated by enquiring the scientific communities and many other Stakeholders. During the Operational phase, the different components of the new RI will be depicted including governance model strategies for interaction with national Authorities and the existing RIs, the IT-architecture model, services to be provided and a business plan. Finally, a Feasibility phase is proposed to develop virtual exercises simulating the operations of the RI. The final result of the project will be the CDR to realize EPTRI.

Keywords: paediatric translational research,drug development
EU Relevant, Inclusive, Timely, Trusted, and Open Research Innovation Indicators (EURITO)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Denmark,United Kingdom
Call: Better integration of evidence on the impact of research and innovation in policy making (H2020-SC6-CO-CREATION-2017, 2017)
Start date: 2018-01-01
End date: 2021-07-31
Duration (months): 43.0
Total project cost (EUR): 1469642.5
EU funding (EUR): 1469642.5
Participants: 4
Project status: SIGNED

Big data and data analytics offer significant opportunities to transform Research and Innovation (R&I) policy with a new generation of more relevant, inclusive and timely indicators than those already available, potentially enabling better decisions with bigger (and better measured) impacts. However, concerns about the representativity, accuracy and interpretability of new data sources and methods is slowing down their acceptance. EURITO brings together a unique consortium of organisations with strong capabilities in R&I policy, big data analytics, machine learning and data visualisation with the goal of taking new data sources and methods from the periphery of R&I policy to its core. To achieve this, we will adopt a work process inspired by the findings of a DG RTD funded project on Data Mining for Research and Innovation Policy that Nesta was involved with as a technical expert. We will start with a scoping stage where we engage with policy and data stakeholders to discover R&I policy user needs, then turn those needs into agile R&I analytics data pilots in a exploratory stage. We will scale-up the most promising pilots to generate next generation, relevant, inclusive, timely and open R&I indicators, which we will then validate rigorously, and communicate using interactive visualisation tools that support decision-making, encourage further exploration of the data, and open it up to wider audiences, making R&I policy-making processes more transparent and democratic. The potential impacts of EURITO include better informed and targeted R&I policies, new opportunities for innovation that build on the open data, open code and open knowledge developed throughout the project, an enhanced understanding of innovation systems, and new opportunities for information sharing and collaboration between policymakers, researchers and data businesses.

Keywords: research and innovation policy,big data,data analytics,science,technology and innovation indicators,innovation systems,industrial policy,emerging technologies,evidence based policy,data driven
Cost- and Climate-Efficient Milk Cooling Using Slurry Ice and Natural CO2 (KUBBI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Faroe Islands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-03-01
End date: 2019-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

KUBBI COOLING is a milk cooling technology for dairy farmers based on slurry ice as the active cooling ingredient and natural CO2 as refrigerant. The main advantages for the end users (dairy farmers) are superior milk quality, higher raw milk prices and significantly lower energy costs for milk cooling and storage. KUBBI COOLING enables unprecedented rapid cooling of the fresh milk (30-60 sec. vs. 90-120 min.), being 120-180-fold faster than conventional milk cooling systems; this in turn enables much better preservation of valuable proteins in the fresh milk and inhibits bacterial spoilage. The advantages for the milk quality are decreased microorganism growth and slower rancidification (degradation) of the milk fat, directly and positively impacting the taste and the smell and extending the shelf life by 1-3 days. The timing of KUBBI COOLING technology is ideal since recent EU regulation encourages adoption of halogen-free refrigerant solutions which have none to insignificant Ozone Depletion and Global Warming Potentials (ODP and GWP). By supporting Commissions’ efforts to phase out and ban conventional refrigerants, we bring forward a solution working 24/7 for farms with 50-350 milking cows, using milk machines or robotic milking systems (estimated target 30,000 farms in Northern Europe alone). LogPh Ltd.’s ambition is to introduce resource-efficient and cost-effective solutions for healthy and high-quality food. KUBBI COOLING is produced as a size-customable module (as opposed to several separate parts of the conventional milk cooling systems) and comes in 4 different sizes with the highest capacity cooling up to 10,000 l milk per day. In a branch which has an acute shortage of cooling technicians, KUBBI COOLING is designed to be easy to install and support, without the demand for a specialized technician.

Keywords: milk cooling technology,slurry ice,natural co2
Resolving the Perceptual Prediction Paradox (ConflictedPrediction)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom,United Kingdom,United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-12-01
End date: 2026-11-30
Duration (months): 60.0
Total project cost (EUR): 1999707.0
EU funding (EUR): 1683958.75
Participants: 4
Project status: SIGNED

Our sensory receptors are bombarded with noisy, continuous streams of information. From these streams, our brains must construct percepts that are (1) veridical representations of the world, and (2) informative – i.e., highlighting what we did not already know. Cognitive science has suggested that our brain meets these challenges by using probabilistic expectations to shape our perceptual experiences. However, there are currently two broad classes of theory concerning how expectations shape perception, that are both supported by large bodies of evidence and mutually incompatible: some theories propose that we upweight what we expect to generate veridical representations, whereas others propose that we downweight what we expect to privilege the most ‘newsworthy’ information. ConflictedPrediction will test a new theory addressing and solving this paradox for the first time, to determine how perception can be rendered both veridical and informative. I propose that probabilistic knowledge pre-emptively biases perception towards what is likely, to generate largely veridical experiences rapidly. However, if the input is particularly surprising, catecholamine release – acting to aid learning – reactively enhances perception of these inputs by modulating sensory gain. This perceptual enhancement will generate a clearer estimate of these highly unexpected events to guide model-updating. To test the theory, ConflictedPrediction will use temporally- and spatially- sensitive neural measures (EEG, MEG, 7T fMRI), in combination with computationally derived parameters of perception and unexpectedness. This interdisciplinary project therefore will unify understanding of perception and learning across typically isolated scientific domains. Its findings will chart a new research frontier for understanding how the brain surmounts key computational challenges, enabling us to survive and thrive in a challenging sensory world.

Keywords: perception,prediction,expectation
STARs that 'R' Young : When do stars form in clustered environments? (STARRY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EID) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-02-01
End date: 2020-01-31
Duration (months): 48.0
Total project cost (EUR): 546575.76
EU funding (EUR): 546575.76
Participants: 2
Project status: CLOSED

STARRY (STARs that ‘R’ Young) is a twin site EID that will provide training to 2 inexperienced researchers in the development of sophisticated research tools in order to exploit, interpret and analyse astronomical data from state-of-the-art observatories in the field of star formation. The joint training programme is provided by world experts in stellar astrophysics at the University of Leeds, UK and in developing, maintaining and exploiting space science data archives at ISDEFE in Madrid, Spain. The programme is extremely timely in exploiting the astrophysical data that are now becoming available from the European Space Agency’s (ESA) mission GAIA and other, mainly European-led, sky surveys. These new developments allow us to answer a current and significant question in the field of the formation of stars, namely: “do massive stars form in clusters?”. The science question requires a particular, novel, functionality to interpret and analyze these new data, and the programme brings together both the academic sector and the non-academic sector to achieve this. The tools which will be developed in the Work Packages in order to address the current scientific question have the potential to enable future studies in many branches of stellar astrophysics, and beyond. Throughout, emphasis is put on skilling a new generation of researchers to work and communicate cross-borders which is vital for the future competitive health of this sector. In short, the need for the development of new analysis tools is identified by a clear and current research question. Its implementation will have a long term benefit to ISDEFE which will ultimately lead to a competitive commercial advantage for the company across Europe. In addition, a new generation of researchers is provided with a research and transferable skillset designed to exploit the considerable European investment in space.

Keywords: star formation,star clusters,distances,data archives
Redesigning the Photosynthetic Light Reactions (PhotoRedesign)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Czechia,United Kingdom
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-04-01
End date: 2026-03-31
Duration (months): 72.0
Total project cost (EUR): 7496829.5
EU funding (EUR): 7496829.0
Participants: 3
Project status: SIGNED

Oxygenic photosynthesis uses the energy of sunlight to generate the oxygen we breathe and the food we eat, but the vast majority of the received solar energy is not converted to biomass. Enhancing photosynthesis to improve the production of food, energy and high value compounds is a compellingly important challenge that has not been taken up yet, because it requires the modification and exchange of large ensembles of interacting photosynthesis components from different organisms. For the first time, we will undertake the comprehensive redesign of photosynthesis to enhance its capacity to harvest and safely convert solar energy. To achieve this, we combine in our team unique and complementary expertise in genetics, biochemistry and biophysics in the full range of bacterial and plant photosynthetic organisms. We will combine genetic engineering with new approaches from synthetic biology and adaptive evolution to create a novel enhanced variant of photosynthesis in the model cyanobacterium Synechocystis as chassis. The ground-breaking overall objective is to combine photosystems from different photoautotrophic organisms, including de novo-designed antennas in reimagined photosystems. By employing a multidisciplinary approach for combining different natural and de novo-designed photosynthesis modules in one adaptable bacterial chassis with the goal to create a novel enhanced type of photosynthesis, PhotoRedesign goes far beyond conventional applied and fundamental photosynthesis research. PhotoRedesign will establish new model systems and toolkits for the next generation of photosynthesis researchers, and it develops a novel concept for modifying complex processes, hitherto considered to be immutable. In consequence, PhotoRedesign will advance photosynthesis research and create the basis for improving the productivity of economically-relevant photosynthetic organisms.

Keywords: photosynthesis,light reactions
Multi-compartmental Tumor-on-a-Chip (MTOAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2021-01-06
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Breast cancer is one of the most common causes of cancer-related death in women all over the world. Although therapeutic approach like surgery, chemotherapy, radiation and targeted therapy reduced the risk of cancer specific mortality. Still there is a risk of cancer recurrence and mortality. Cancer research is typically dependent on 2D system and animal model which leads to conflicting the result due to cellular behavior, phenotypes, gene expression level and expensive animal studies (Szot et al., 2011). In this way 3D microfluidics systems are designed to fulfill the gap between 2D and animal model for screening and testing of drug. The present proposal is conceptualize to bridge the gap between 2D and animal model effectively, by designing the Organs-on-chip (3D), microfluidics system of tumor microenvironment to evaluate the efficacy of combination of anticancerous drug. Herein, the multi-compartment microfluidics platform will be generated by co-culturing of cancer cells, fibroblast and endothelial cells into biocompatible hydrogel, to produce a multi-organ-on-a-chip devices. It recapitulates organ-like functions in each compartment and a vascular-channel between the compartments produce preliminary human on-chip. This 3D microfluidics system dedicated to evaluate the efficacy of anticancerous drug will be helpful to improve the future drug development applications.

Keywords: microfluidics,tumor on a chip,biomaterials,in vitro 3d models,pharmaceutical testing
Adaptation of human brown adipose tissue to overnutrition (BATON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-01
End date: 2025-07-23
Duration (months): 36.0
Total project cost (EUR): 250497.6
EU funding (EUR): 250497.6
Participants: 2
Project status: SIGNED

Brown adipose tissue (BAT) is a highly thermogenic tissue whose main function is to produce heat to maintain mammals’ body temperature. In humans, it has long been believed that BAT is either absent or irrelevant in adults. However, a decade ago, several independent research groups confirmed the presence of metabolically active BAT in human adults. In rodents, BAT plays a key role in the adaptation to overfeeding, protecting murine from diet-induced obesity. Whether this phenomenon also occurs in humans is still unknown. To date, technical limitations for in vivo human BAT assessment have precluded us from adequately studying it. The BATON study will first aim to develop a new method to accurately measure human BAT volume and thermogenic capacity in vivo. New approaches based on recent advances in human BAT metabolism (i.e. BAT’s unique ability to burn its own intracellular triglycerides and the recently discovered, and unexpected, capacity of human BAT to be activated through β2 adrenergic receptor agonism) will be tested in a randomized cross-over study. Ten young healthy adults (18-30 years old, 5 men and 5 women, with a body mass index <25kg/m2) will undergo 3 experimental sessions including sequential positron emission tomography-computerized tomography and magnetic resonance imaging and spectroscopy scans. Later, the newly develop method(s) will be used to measure BAT volume and thermogenic capacity changes in response to a 4-week 40% overfeeding, in a proof-of-concept overfeeding pilot study. Twelve healthy adults (18-30 years old, 6 men and 6 women) with a body mass index <25kg/m2 will participate in this randomized controlled trial. After baseline assessments, participants will be randomized (blocking the randomization by sex) to a 4-week weight maintenance diet (control group) or a 40% overfeeding diet. A 5-days weight maintenance diet will be prescribed before baseline and post-intervention assessment.

Keywords: human brown adipose tissue,overfeeding,energy expenditure,pet ct
Do extreme climatic events facilitate plant invasions? (EXTREME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-01
End date: 2018-05-25
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Extreme climate events (ECEs) are projected to increase in magnitude and frequency as global warming intensifies the global water cycle. Global warming is also changing species distribution patterns by affecting native plant communities and by enabling alien species to expand beyond their native range. We increasingly realize that climate change and biological invasions act together, leading to even more dramatic outcomes. However, how ECEs will affect the incidence and strength of biological invasions remains poorly understood. Therefore, the overall objective of EXTREME is to develop a mechanistic understanding of how increased climatic variability and ECEs affect alien plant invasions. I will relate the incidence of species invasiveness with climate variability and the occurrence of ECEs, using drylands as study system. A novel approach to develop further understanding is the inclusion of genomic features in explaining the response to ECEs. A modelling approach will be combined with a common-garden experiment to study the effect of drought and heavy rainfall on the performance of native and alien plant species in a model dryland system in South Africa. EXTREME will allow me to diversify my individual competence by acquiring new skills (statistical and climate modelling and GIS) and competencies (academic leadership, proposal writing, project management). EXTREME will strongly benefit my inter-sectoral and interdisciplinary expertise and strengthen my international network, which is also beneficial for the host. A two-way transfer of knowledge is guaranteed since EXTREME combines my expertise in invasion and evolutionary ecology with the host’s expertise in the effect of climate variability and extremes. Therefore, EXTREME is not only expected to catalyse my career development, but will contribute to Europe’s knowledge-based economy and society by providing invaluable knowledge on climate change and invasive species that is of the highest priority in the EU.

Keywords: extreme climatic events,climatic variability,invasive species,drylands,plants,precipitation,whole genome duplication,polyploidy