Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PHOtonic integrated OCT-enhanced flow cytometry for canceR and cardiovascular diagnostics enabled by Extracellular VEsicles discRimination (PHOREVER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Partnership: Photonics (co-programmed)
Countries involved: Greece,Netherlands,Germany,Switzerland
Call: Advanced multi-sensing systems (Photonics Partnership) (RIA) (HORIZON-CL4-2022-DIGITAL-EMERGING-01, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 4973882.5
EU funding (EUR): 4973882.5
Participants: 9
Project status: SIGNED

Imaging tools such as the Computed Tomography (CT) and the Magnetic Resonance Imaging (MRI) can offer diagnosis of the cancer and the cardiovascular disease (CVD), but not insight into the molecular mechanisms that promote their occurrence, progression and possible resistance to treatment. Information about these mechanisms is present however in the blood. Extracellular vesicles (EVs) are secreted into the blood, and can inform us about the state of their cells of origin, and by extension, about the presence and progression of diseases. Unfortunately, their detection is still imperfect due to the ultra-small size (50-200 nm) of most of them. PHOREVER will develop a disruptive multi-sensing platform that will enable for the first time the reliable detection of EVs with size down to 80 nm, the detection of EVs with specific biomarkers (proteins) on their surface, and the calculation of the corresponding EV concentrations in the blood. Its operation will be based on 3 sensing modalities: Flow-cytometry (FCM) with 4 wavelengths (405, 488, 633 and 785 nm) as the main modality for EV detection and size classification, dual-channel swept-source optical coherence tomography (SS-OCT) with 2.5 µm resolution for imaging of the sensing area and noise reduction of the FCM measurements, and fluorescence sensing at 488 nm for biomarker detection after staining. The key components will be the 2 photonic integrated circuits in TriPleX and the 3 microfluidic chips, which will be integrated as a compact point-of-care device. The medical impact can be ground-breaking. The first use case will be related to pancreatic cancer with focus on progression monitoring, metastasis risk assessment, and treatment efficacy evaluation. The second use case will be related to stroke with focus on its fast and precise diagnosis for time-to-treatment reduction. In either case, data analysis empowered by artificial intelligence will correlate the measurement data to disease specific medical information.

Keywords: flow cytometry,optical coherence tomography,fluorescence,extracellular vesicles,silicon nitride,pics,swept source,microfluidics,ai,cancer,poc,stroke
Decipher how mRNAs are captured at specific subcellular locations to support local translation in neurons (RNA.ORG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499140.0
EU funding (EUR): 1499140.0
Participants: 1
Project status: SIGNED

Brain function requires precise regulation of the neuronal proteome which involves localizing thousands of mRNAs to neurites, where specific subsets are translated at the required subcellular locations. Although local translation is well-established, the mechanisms that ensure the capture and translation of specific mRNAs at the correct subcellular location remain elusive. A better understanding of this process is urgent since dysregulation of mRNA localization and translation is emerging as a key pathological event in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). In RNA.ORG, I aim to define, at a molecular level, how the coordination between mRNA transport, capture and local translation occurs to support neuronal function. Recent work from my lab and others has shown that multiple organelles interact with mRNA and translational machinery. This raises the exciting possibility that organelle interactions coordinate mRNA distribution, local capture and selective translation. I have developed tools to visualize and manipulate organelle position and contacts at nanoscale resolution. Here, I will leverage these tools and directly control mRNA positioning to elucidate the importance of mRNA capture in neuronal function and intervene in its dysregulation in ALS. In combination with live-cell and super-resolution imaging, RNA-sequencing and proteomics, this project will address the following key objectives: 1) Resolve the subcellular distribution and dynamics of neuronal organelle-mRNA contacts 2) Unravel the functions of organelle-mediated mRNA capture at specific subcellular locations 3) Determine the role of dysregulated mRNA capture in amyotrophic lateral sclerosis RNA.ORG will elucidate novel mechanisms on the subcellular capture and translation of specific mRNAs in neurons and will provide new insights into the role of local mRNA positioning in neuronal development, physiology and pathology.

Keywords: axonal mrna translation,mrna localization
Rethinking the future of clean cooling through a revolutionary class of thermally-driven chiller based on a novel bio-based thermochemical material (CharCool)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Italy,Netherlands,Belgium,Spain,Poland
Call: EIC Pathfinder Challenge: Clean and efficient cooling (HORIZON-EIC-2023-PATHFINDERCHALLENGES-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 3857353.75
EU funding (EUR): 3857353.75
Participants: 6
Project status: SIGNED

In response to set targets for reducing our carbon footprint and securing our energy future in Europe, the CharCool project combines the use of natural energy and nature-based solutions to achieve clean and efficient cooling. CharCool is an innovative and sustainable heat-driven cooling system, where the excess of clean renewable energy or waste heat is stored in a modular thermochemical energy storage system that allows for seasonal storage. CharCool challenges the current vision of cooling industry by proposing a system that is highly flexible and reliable, thanks to its coupling with a high-energy density (200 kWh/m3) and inexpensive mid-/long-term thermochemical material. The CharCool chiller is supplied by a new interchangeable (thus rechargeable) modular thermopile made of biochar obtained from low-cost agricultural by-products, impregnated with environmentally-friendly and easily available inorganic salts. The chiller operates with water as the refrigerant, offering a completely natural and safe alternative to the current electricity-driven and environmentally-harmful cooling solutions. CharCool runs on waste heat (e.g. from data centres) or renewable energy sources (e.g. solar thermal or excess wind through power to heat) within a temperature range of 60-150 °C. This offers the advantage of decoupling the refrigeration system from the electricity grid, thus increasing the penetration of renewable energy. Moreover, mobile and modular thermopiles close the spatial and temporal gap between the heat source and the user cooling demand. CharCool clean and efficient cooling technology will reduce the volumes and cost of the current sorption systems by 40% and 50%, respectively. By investing in CharCool, Europe will assert its global research and innovation leadership while creating quantifiable social and economic impacts. This novel technology will partly address energy poverty and create value for the billion-euro-worth heating and cooling market.

Keywords: sorption chiller,water as refrigerant,tcm,biochar,buiding cooling,data center cooling,waste heat recovery,thermal energy storage,thermochemical storage,renewable energy integration
Operator Algebras that One Can See (Graph Algebras)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Poland,Denmark,Italy,Netherlands,Germany,Israel,Canada,United States,Mexico,Australia,Brazil
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 496800.0
EU funding (EUR): 496800.0
Participants: 28
Project status: SIGNED

Graph C*-algebras are analytical objects blessed with a tangible structure and classification theory derived from their combinatorial origins. Through the analysis of directed graphs, including higher-rank graphs or quantum graphs, one can visualize and explore them in intuitive ways lacking elsewhere. They serve as strikingly efficient models for key open problems in noncommutative geometry and topology, as well as in C*-dynamical systems. They also provide a focal point for the much-needed extension of the celebrated Elliott classification program to non-simple C*-algebras. The main objective of the project is to achieve a critical mass for a successful attack on these problems by combining the weight of strong research groups inside and outside the EU, using graph algebras as a unifying vehicle for hitherto unconnected areas of mathematics. The synergy of these new and innovative connections should allow us to develop and apply brand new methods unavailable otherwise. Furthermore, researchers using graph C*-algebras for applications in adjacent fields are likely to provide groundbreaking insights making impact way beyond graph algebras themselves. In particular, we expect to develop an interdisciplinary dimension involving quantum computing. We aim to achieve our objective through networking and transfer of knowledge. Between twenty six partners from the EU and North America participating in the network, there are worldwide leading scientific centers. Among about seventy researchers involved in the project, there are famous experts and extremely efficient mentors of young researchers. Combining them with student members of the network yields a top human-resource infrastructure. An important objective is to take advantage of that potential by creating new career opportunities. Another tremendous asset of the network is a unique opportunity it gives to tie new and lasting connections for successful transcontinental scientific collaboration.

Keywords: higher rank and quantum graphs,topological groupoid,pushout of graphs,pullback of c algebras,semiprojectivity,kk theory,quantum metric space,spectral triple,c dynamics,quantum group
Low-Carbon Multi-component Marine Cementitious Materials for Sustainable and Resilient Infrastructure (LCMMCMs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,Singapore,Portugal,France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 5
Project status: TERMINATED

The objective of this fellowship is to train Dr Xing Ming, through a research project titled “Low-Carbon Multi-component Marine Cementitious Materials for Sustainable & Resilient Infrastructure” (LCMMCMs), to develop sustainable and resilient cementitious materials through the bottom-up approach for marine concrete infrastructures by taking advantages of the research expertise of the Fellow and the hosts. Leveraging the synergistic effects of seawater and supplementary cementitious materials (SCMs), this project will explore the complex interactions during cement hydration and the resulting structural evolution in the assistance of multi-scale ab-initio calculations and advanced in-situ and ex-situ experiments. The research will quantify these effects to optimise the compositions of LCMMCMs, improving both fresh and hardened properties and significantly enhancing their mechanical performance and durability in harsh marine environments. The project will also develop an advanced durability-coupled life-cycle assessment (LCA) model to evaluate the environmental and economic impacts of these materials, supporting the decarbonisation of the construction sector in line with the Paris Agreement and the European Green Deal. By integrating expertise across materials science, chemistry, physics, civil engineering and environmental engineering, LCMMCMs will address the longstanding challenges of sustainability and durability in marine infrastructures. The project will generate valuable scientific outputs, including new hydration models, sustainable cement formulations, and practical industry applications, all contributing to the UN Sustainable Development Goals (SDGs 6, 9, 11, 12 and 14) and the EU Mission: Restore our Ocean and Waters. The outcomes of LCMMCMs will not only support the development of resilient marine structures but also set a new benchmark for sustainable construction practices globally.

Keywords: seawater ab initio calculations low carbon cementitious materials supplementary cementitious materials hydration microstructure durability life cycle assessment
Collaborative Innovation in 3D VLSI Reliability (COIN-3D)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Information Science and Engineering
Countries involved: Greece,Netherlands,Germany,United Kingdom
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 1207881.69
EU funding (EUR): 1207881.69
Participants: 4
Project status: SIGNED

The overarching goal of COIN-3D is to foster strategic networking and knowledge exchange between UTH and leading European research institutions to enhance research management and commercialization capacities in the area of 2.5/3D chiplet architectures. To achieve this objective, the project will establish strong partnerships with European counterparts and create a space for collaborative learning and experience sharing. Additionally, the project will develop tailored training programs and resources to equip UTH researchers and administrative staff with the necessary skills for effective research management and successful commercialization endeavours. The main target of the COIN-3D project is to enhance the research capacity of an entity being active in a widening country with the assistance of more developed countries trying to expose the pathways for innovation and research excellence. Through these initiatives, the project aims to elevate UTH's research profile, stimulate innovation, and contribute to the institution's strategic positioning within the global research community. In addition, our vision aligns seamlessly with the objectives of the European Chips Act , as we work towards cultivating a vibrant ecosystem for semiconductor research, development, and commercialization. A wide number of twinning activities are foreseen, and a strong interaction plan is already in place together with core research activities that can be beneficial for the entire consortium. Our core research plan is moving around one of the most significant research directions in the area of 2.5/3D VLSI systems reliability, i.e., the provision of novel EDA reliability tools for 3D VLSI designs, through the integration of innovative algorithms for physical-level and system-level reliability assessment, optimizing power delivery networks, and modelling aging phenomena, thereby advancing the state-of-the-art in semiconductor system design and ensuring long-term reliability.

Keywords: twining activities,research capacity,knowledge exchange,mobility framework,joint research and training activities,strategic networking,2 5 3d chiplet architectures,eda tools,vlsi reliability
Functional impact of the psychiatric risk gene CACNA1C in human iPSC-derived microglia (Psy-hiPSC microglia)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 1
Project status: SIGNED

Psychiatric disorders such as major depression, bipolar disorder, schizophrenia, and autism are highly prevalent chronic diseases. However, their underlying pathophysiology is still largely unknown. Genomic studies have identified single nucleotide polymorphisms (SNPs) in the CACNA1C gene that are robustly associated with all of these major psychoses. Among these is the main non-coding risk SNP rs1006737. Beyond that, a gain-of-function mutation in CACNA1C has been described, which causes a multiorgan phenotype including severe cardiac arrhythmias, immune deficiency, cognitive abnormalities, and autism, named Timothy syndrome (TS). Immune alterations plus the involvement of their primary mediators in the brain, the microglia, have also been reported for psychiatric disorders. Based on this, we aim to introduce the risk A-allele of the CACNA1C SNP rs1006737 as well as the TS mutation G406R into human iPSC control lines using CRISPR base editing. The generated isogenic lines are then differentiated into iPSC-derived microglia cells (iMGs) and undergo a systematic functional characterization, including the analysis of transcriptomic profile, intracellular calcium levels, motility, phagocytic activity, cytokine release, cellular bioenergetics, and mitochondrial parameters. Furthermore, the newly created iMG cultures are tested in brain organoid systems to assess their effects on neuronal activity and function via multielectrode array recordings and single nuclei sequencing. The obtained results will contribute significantly to elucidating whether microglial function is causally affected by the selected CACNA1C risk variants, what underlying checkpoint mechanisms are involved, and whether these changes compromise microglia-neuron interactions, thereby impairing neuronal activity and function. Overall, this study will add to a better understanding of the role microglia play in the pathogenesis and/or progression of CACNA1C-associated psychiatric disorders.

Keywords: microglia,neuroinflammation,human induced pluripotent stem cells,immunocompetent brain organoids,crispr base editing
Flexible hybrid electrical systems for sustainable process intensification on-demand and where required (FLEXHYON)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Countries involved: Italy,Poland,Spain,France
Call: Alternative heating systems for efficient, flexible and electrified heat generation in industry (HORIZON-CL5-2024-D4-01, 2024)
Start date: 2025-01-01
End date: 2028-06-30
Duration (months): 42.0
Total project cost (EUR): 6257711.16
EU funding (EUR): 5247799.25
Participants: 9
Project status: SIGNED

Recognizing the significance of energy efficiency in industry and carbon emissions reduction, FLEXHYON is proposing a clever combination of alternative fully electrified heating systems (microwave, heat pumps, ultrasound) to tackle three specific industrial processes: ultrafast drying of compact material, drying of granular materials and distillation/extraction of ground material to address their urgent need to transition from fossil energy to renewable and low-carbon energy sources. Three optimized prototypes will be built and demonstrated in 3 industrial environments: ceramics, feed production, biomass. The quality and economic impact of the developments will be evaluated using LCA and LCC; environmental and technical performances, health protection, safety will be demonstrated and validated. Sound market strategies will be developed, giving clear indications on scalability, transferability and replicability across different industrial sectors, commercialization and deployment will be achieved through development and validation of set of business models for the 3 business cases. The FLEXHYON solutions will exhibit significantly higher energy efficiency in comparison to traditional fossil fuel-based heating technologies, therefore leading to a reduction in GHG emissions, maximizing primary energy savings, and enabling higher production flexibility (e.g. production on-demand, production on-site). Their scalability (upscaling, downscaling) will allow to better follow market demand and enable leaner production paradigms. To achieve the project goals, FLEXHYON combines 9 partners covering the whole technical value chain required for the development and validation of alternative fully electrified heating systems. The Consortium will also implement different dissemination and communication activities to raise awareness about the benefits of alternative heating systems in industry and exploitation opportunities from know-how generated and exploitable results developed.

Keywords: flexible hybrid electrical systems,microwave,heat pumps,ultrasound,ceramics,feed production,biomass,renewable low carbon energy sources