Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Elliptic Integrable Systems: solutions, deformations and integrability (ELLIS-SDI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-09-26
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

The proposal studies relativistic generalizations of quantum integrable models of Calogero-Moser-Sutherland (CMS) type and their deformations, and the correspondence between the CMS models and the Painlevé hierarchies. It is divided into several parts. The first part investigates the van Diejen model (which is the most complicated model in the CMS family) and its sophisticated limiting case proposed by Takemura. The aim is to construct exact eigenfunctions of these two models using the kernel function methods. These eigenfunctions belong to an emerging new class in the theory of special functions. The second part is devoted to the study of integrable deformations of the relativistic CMS model (Ruijsenaars model), going back to the works of Chalykh, Feigin, Veselov and Sergeev. In the trigonometric case, the deformed models are known to be integrable and the eigenfunctions of the principal Hamiltonian are given in terms of super-Macdonald polynomials. Using the kernel function identities, I will prove that all higher Hamiltonians of this model are diagonalized by the super-Macdonald polynomials. This will be used to establish orthogonality of the super-Macdonald polynomials. Extending this, I plan to establish integrability of the elliptic case. Furthermore, by using algebraic tools such as Cherednik operators and double affine Hecke algebras, and building upon a recent work of Chalykh, I will construct quantum Lax matrices for the deformed models in all cases. Lastly, we aim to find a conceptual link between elliptic Cherednik algebras and higher Painlevé systems. Namely, first we will obtain the classical Inozemtsev system from Cherednik algebra by a Hamiltonian reduction. By relating this to the recent results of Bertolo, Cafasso, and Rubtsov, we will then find an alternative and more natural interpretation of the higher Painlevé equations as isomonodromic deformations.

Keywords: quantum integrable systems,special functions,calogero moser sutherland models,calogero painlev correspondence
Nano bio-responsive systems designed to avoid staphylococcal colonization of implant interfaces (NanoBioRS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-01
End date: 2025-03-31
Duration (months): 36.0
Total project cost (EUR): 279250.56
EU funding (EUR): 279250.56
Participants: 1
Project status: SIGNED

Antimicrobial resistance (AMR) is responsible for 25,000 deaths per year in the EU and costs EUR 1.5 billion annually. Methicillin-sensitive Staphylococcus aureus (MSSA), Methicillin-resistant S. aureus (MRSA) and S. epidermidis remain a serious problem in the treatment of periprosthetic joint infection (PJI). After surgery, bacteria may attach to the surface of prosthetic joints to form biofilms. The fate of an available surface can be conceptualized as a race between tissue cell integration and bacterial adhesion to that same surface. If the race is won by tissue, then the surface is occupied and defended and is thus less available for bacterial colonization. The integration of the synthetic routes for smart molecular coatings doped with anti-staphylococcal agents that promote tissue growth, their biological responses and biointerface interactions into functional nano bio-responsive systems (NanoBioRS) able to avoid PJI is an unexplored opportunity for innovation. In order to tackle PJI and to contribute to avoid the development and spread of antimicrobial resistance, NanoBioRS aims to engineer smart coatings equipped with three frontlines: (i) Increased adhesiveness of their interface to favour tissue cell integration. (ii) Smart responses to eradicate MSSA, MRSA and S. epidermidis using antimicrobials that are not prompt to resistance development. (iii) Means of avoiding biofilm and horizontal gene transfer (HGT) of AMR. Thiol-modified polymers, surface-tethered stimuli-responsive polymer brushes and antimicrobial/antifouling agents will render coatings with eukaryotic cell adhesive, smart bacterial contact-kill and anti-biofilm properties, respectively. Endonucleases will be used to avoid biofilm and HGT of AMR. Implant surfaces will be modified with NanoBioRS. Nanoscale characterization will allow for the understanding of biointerface interactions taking place during eukaryotic cell colonization and bacterial invasion of implants.

Keywords: thiomers,surface thedered polymer brushes,stimuli responsive,tissue regeneration,anti staphylococcal,anti biofilm,anti horizontal gene transfer
Towards effective and efficient pest management in agriculture (PESTEFFECT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-02-02
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Résumé: The reduction of environmental and health risks from pesticide use is a major challenge for agriculture and on top of the agricultural policy agenda. Despite substantial efforts, current pesticide policies have not reached their reduction targets. Recent research shows that targeting farmers’ application behavior could be key for advancing pesticide policies. However, our theoretical understanding of the farmers’ decision-making process is limited and empirical studies on the main drivers of inefficient decisions are missing. The interdisciplinary PESTEFFECT project will i) advance our understanding of farmers’ pesticide use decisions, ii) quantify impacts of the main drivers of inefficient decisions, and iii) identify risk reduction potentials on a regional level. In the project, we will i) develop a conceptual and empirical model of farmers’ pesticide use decisions that integrates concepts from agricultural economics, agronomy, and ecology, ii) provide the first empirical analysis of economic and environmental effects of inefficient pest management decisions using an econometric model and iii) provide temporally- and spatially explicit assessments of risk reduction potentials on a regional level using multi-layered maps. For our analysis, we will use a unique, long-term dataset on farmers’ management decisions, environmental conditions, and biodiversity (losses) from Western France. Results will support the development of pesticide policies targeting inefficient pest management decisions and the creation of guidelines for farmers and farm advisors. The project will thus contribute to a more sustainable agriculture in Europe.

Keywords: agricultural economics,pesticides,environment and health risks,farmers behaviour,risk reduction,pesticide policies,sustainable agriculture
Exploring the identity construction of IS members through linguistic markers in online discourse (ISICD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

The proposed research (Islamic State identity construction through discourse or ISICD) will explore the discourse of the Islamic State (IS) with the aim of contributing to a system of detecting, tracking, monitoring and studying such discourse in the Internet. As a tool, language allows us to establish our relationship with people discursively, to represent and distort reality, and to convince those with who we communicate to act in a certain way. This makes it a valuable resource for exploring larger motives and ideologies that are not explicit at the level of the text itself. The growing popularity of IS and its global influence depends on the ability of its members to communicate and share information online. As a consequence, its social identity as a political and religious group is established through online language in particular. The research will be carried out with a triangulation methodology, incorporating corpus linguistic methods with a discourse analysis frameworkand systemic functional linguistics, to determine four specific objectives (O): O1 how extremism is identified within language use through quantitative linguistic markers such as n-grams and collocations; O2 how extremism is identified through qualitative structural patterns such as transitivity, modality and appraisal; O3 how the use of these linguistic traits explains rhetoric and persuasive strategies used by IS; O4 what these findings tell us about how IS ideology is represented discursively. The findings from this research will provide a much-needed comprehensive account of the linguistic markers that characterise online identity of IS members. The project will develop original quantitative methodologies which will be transferrable to other contexts in which ideology is constructed in online communities. The findings will also have a wider relevance in areas such as sociology, the media, anti-terrorism research, politics and border control.

Keywords: discourse analysis and identity politics show how linguistic fingerprints can be used to measure the,spread of extremists attitudes to local populations over time
European university of technology - Experimentation to Transform Research Activities and Steering (EUt EXTRAS)

Framework: Horizon 2020 — Science with and for Society
Action type: Coordination and support actions
Countries involved: Germany,Spain,Ireland,Cyprus,Bulgaria,Romania,Latvia,France
Call: Support for the Research and Innovation Dimension of European Universities (Part II) (H2020-IBA-SwafS-Support-2-2020, 2020)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 1999996.0
EU funding (EUR): 1999996.0
Participants: 8
Project status: SIGNED

The ambition of EUt+ project EXperimentation to Transform Research Activities and Steering (EUt EXTRAS) is to support the emergence of intercampus knowledge-creating teams across our institutions, across disciplines, and across types of activities, towards a new approach of the environment and of steering and execution of research. It will be a test bed to establish a common roadmap for research and innovation at the EUt+ level by 2030 to validate a solid methodology of institutional transformation fully integrating the challenges of European technology development. We want to co-construct a pilot experimentation to achieve a critical mass in research that is flexible, decentralised and collaborative, to support the institutional transformation necessary for Europe’s industrial renewal. This entails opening up new career opportunities for the fluidity of ideas and knowledge (both within the university and with the private sector, and the other way around), and avoiding the brain drain often associated with such endeavors. Since its beginnings, EUt+ has emphasized the importance of involving the local communities: universities of Technology should have a direct impact on local economic structures by providing educational opportunities to underrepresented groups, and know-how to local companies. We will develop human capital to steer Europe towards a new path of excellence, do science and create technology with and for society, connect technological research with its peripheral environment, conduct series of internal and external analyses for an informed decision-making, create commons in terms of resources and infrastructure, and - importantly - develop, document, and disseminate an assessment methodology with a strong participatory and bottom-up approach. As the EUt+ motto reminds us, we always Think Human First.

Keywords: evaluation methodology,human capital and careers management,relations sciences society,open science,common infrastructure and roadmap,analysis and information for research orientation decision
Reactions That Translate mRNA into Drug-like Molecules (TRIGGDRUG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2016-01-01
End date: 2020-12-31
Duration (months): 60.0
Total project cost (EUR): 2470400.0
EU funding (EUR): 2470400.0
Participants: 1
Project status: CLOSED

How could a molecular cancer therapy look like in 2040? In cancer, gene expression is deregulated due to amplification, mutation and translocation of genes. Next generation RNA sequencing provides us with the opportunity to identify the number and identity of the gene products aberrantly expressed in a patient. But do we have methods that take advantage of the personalized sequence data? In this research project we propose the idea to use the RNA molecules expressed upon disease-type gene expression as instructors for the chemical synthesis of drug-like molecules that cure the disease. Accordingly, drug-like molecules would only be formed in those cells that express the disease-specific RNA molecules. Such a personalized molecular therapy would eliminate side effects caused by unwanted perturbation of healthy cells. The idea to use cellular RNA molecules as triggers for drug synthesis requires methods that couple RNA recognition with a change of chemical reactivity. Reactive molecules must be able to “read” and “translate” the sequence of a RNA molecule into a drug-like output. We will develop mRNA-triggered reactions that i) proceed with turnover in template to cope with low mRNA copy numbers and ii) allow the single-step synthesis of highly active drug-like molecules to address deregulated protein targets inside cancer cells. To achieve this aim, we will advance chemical acyl transfer and alkylidene transfer reactions. The reactions on disease-specific mRNA will form peptides/peptidomimetics/small molecule-based kinase inhibitors which will induce apoptosis in cancer cells. We will target validated drug targets. Synergy between the nucleic acid and protein worlds will be harnessed. Furthermore, we will develop a RNA-promoted reaction with turnover beyond product inhibition. This will enable a transcriptome-activated photodynamic therapy. In a nutshell, we will develop a chemistry-based tool to hijack disease mRNA and rewire the cell death program.

Keywords: nucleic acid chemistry,peptides,proteins,catalysis,apoptosis,smart drugs
Biomechanical Characterization of Carotid Plaque Rupture (BIO-CAPTURE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Stroke is the second leading cause of mortality worldwide. Most stroke events are triggered by an atherosclerotic plaque rupture in a carotid artery. Current clinical decisions for the carotid plaque removal surgery are made without assessing the plaque rupture risk as no reliable means exists today. Biomechanics can help to develop such risk assessment tools; yet, the fundamental knowledge on biomechanical descriptors of plaque rupture is missing. This project aims to provide biomechanical characteristics of atherosclerotic plaque rupture. This will be done by combining experimental work, high-end plaque imaging and computational modeling. First, non-existing biomechanical plaque rupture data will be collected from a novel experimental approach of physiological, ex-vivo inflation/rupture tests with atherosclerotic human carotid arteries. The pre-rupture and rupture strain distributions in plaques during the tests will be assessed in 3D via a cutting-edge high frequency ultrasound technique. With a novel inverse finite element (FE) technique, heterogeneous material properties of the plaques will be identified. This unique material information will be used in plaque-specific FE models to compute 3D pre-rupture and rupture stress distributions in the plaques. The assessed plaque strain and stress fingerprints will be evaluated for their predictive value of plaque rupture. The essential knowledge on biomechanical characteristics of plaque rupture will aid making more accurate surgical treatment decisions to prevent stroke-related mortality and morbidity. Besides the high-impact research, this fellowship will also result in enhancement of the applicant’s skill set through the valuable training on ultrasound imaging, histology and pathomorphology examination. Furthermore, the fellowship will allow him to return to the EU research environment, and bring back his expertise in tissue experimentation and modeling, and advanced FE analysis.

Keywords: biomechanics,atherosclerosis,finite element modeling,plaque rupture,stress and strain analysis,stroke,ultrasound imaging
Mechanisms of protein translocation in ER-associated protein degradation and the related protein import into the apicoplast of Plasmodium falciparum (ERAD_SELMA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-03-01
End date: 2021-05-31
Duration (months): 63.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

The removal of misfolded proteins is an essential process in all cells. Failure to dispose of such proteins often results in disease. A particularly intriguing process serves to discard misfolded proteins from the endoplasmic reticulum (ER). The ER does not itself degrade proteins, so machinery has evolved that moves misfolded proteins into the cytosol where they can be degraded by the proteasome. This retro-translocation process is called ERAD (for ER-associated protein degradation). By comparison with other membrane translocation processes, the mechanism of ERAD is poorly understood. How are misfolded proteins distinguished from folding intermediates? How are proteins moved across the membrane? How is the energy for membrane translocation provided? To answer these fundamental questions I will use a combination of in vitro reconstitution experiments with purified proteins from S. cerevisiae and experiments in intact yeast cells. It appears that some ERAD components have been adapted to function in protein translocation in a very different setting. Many parasites like the malaria causing P. falciparum contain a plastid-like organelle, called the apicoplast. It is the site of several metabolic pathways essential for the parasite’s survival, and thus an important drug target. Like other organelles of endosymbiotic origin, the apicoplast lost most of its genetic information and has to import proteins. This is a particularly challenging endeavour because four membranes surround the apicoplast. It is thought that symbiont specific ERAD-like machinery (SELMA) mediates proteins translocation across the second-outermost membrane. However, not much is known about SELMA. What is its molecular composition? Which aspects of SELMA are conserved in comparison to the classical ERAD machinery? I will address these important questions using a completely novel combination of biochemical and genetic approaches.

Keywords: endoplasmic reticulum associated protein degradation,protein translocation,apicoplast,membrane protein biochemistry
Fabrication of Polysaccharides-Protein complex Nano-Hybrid Scaffold as regenerative biomaterial for bone tissue engineering (PONS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

The development of new biomaterials in bone tissue engineering requires an interdisciplinary joint-venture combining material and biomedical sciences. The aim of the regenerative biomaterial is to repair the functional defect or damages by generation of a bone substitute. The biomaterial has to be highly engineered at the molecular level to mimic the function of the extracellular matrix including complex cell-material interactions and physical properties of the scaffold. The focus of this proposal is to fabricate an organic-inorganic complex nanohybrid scaffold as a bone implant for applications in tissue engineering. The nanohybrid scaffold is based on three components: an inorganic particle containing biological carrier molecules (BCM), polysaccharide (cellulose) and protein (collagen). Layered-double hydroxides (LDH) inorganic particles will be functionalized with BCM allowing controlled release of biological molecules that will direct cell-material interactions. Polysaccharides (Pol)–Protein (Pro) biomaterials reinforced with LDH-BCM will be fabricated and tested in ectopic bone formation analysis technology which will translate to clinical trials. In essence, Pol-PrO complex reinforced LDH-BCM Nanohybrid Scaffold (PONS) will be developed as regenerative biomaterial in bone tissue engineering and will incorporate cutting edge stem cell technologies, engineering of advanced materials and controlled delivery of biomolecules in vitro and in vivo.

Keywords: biomaterial,bone,polysaccharides,protein,scaffold,tissue engineering,in vivo