Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The molecular diversity of regeneration in the zebrafish spinal cord (SCSC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-08-01
End date: 2022-07-31
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: CLOSED

Because the mammalian nervous system exhibits a limited capacity for regeneration, spinal-cord injury causes permanent damage in humans. In contrast, zebrafish regenerate their spinal cords after damage. Understanding this process in zebrafish might one day suggest regenerative strategies for humans. This proposal therefore aims to elucidate the transcriptional processes that regulate regeneration in the zebrafish spinal cord. Although genome-wide expression profiling has revealed factors that promote spinal cord regeneration, microarray and bulk RNA-seq methods are unable to localize candidates to particular cell types. The molecular diversity of cell types that contribute to spinal cord regeneration thus has not been fully explored, and the cell type-specific roles of the signals that instruct the process remain unclear. The applicant will address this gap by performing single-nucleus RNA-seq on regenerating zebrafish spinal cord and analyzing the data to reveal cell types and cell type-specific gene expression changes. This goal entails three specific aims: 1) Establish a protocol for isolating nuclei from the zebrafish spinal cord. 2) Establish a molecular taxonomy of cell types in the regenerating spinal cord. 3) Characterize cell type-specific gene-expression changes in the regenerating spinal cord. The project will be completed in a laboratory that specializes in single-cell RNA-seq methods and neuroscience, providing exceptional training in the experimental and computational methods associated with high-throughput single-cell analysis and preparing the applicant for a career as an independent investigator. The host institute is moreover a leading research institute at the forefront of neuroscience and single-cell biology, with postdoctoral career support. The proposal will yield an atlas of the cell type-specific transcriptional changes that occur during regeneration, providing new insight and a novel resource for researchers in the field of regeneration.

Keywords: high throughput single nucleus rna sequencing,zebrafish spinal cord regeneration
ENERGY EFFICIENT, SPACE EFFICIENT and COST-EFFECTIVE DATA STORAGE SYSTEM FOR HEALTHCARE (BasePort)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-07-01
End date: 2023-02-28
Duration (months): 32.0
Total project cost (EUR): 2491762.5
EU funding (EUR): 1744233.75
Participants: 1
Project status: SIGNED

The promise of Precision Medicine that was envisioned decades ago with the mapping of the human genome is fast becoming a reality. While genomic research is paving the way for significant advances in healthcare, its practice has led to new challenges for biotechnology firms in terms of increasing data volume, variety and complexity. Given that the data representing a single human genome takes up to 100 gigabytes of storage space, biotech companies engaged in genomic research must develop the computing infrastructure and skills to manage, store, analyse and interpret massive quantities of highly complex data. Healthcare centres, in particular, need a data storage solution that uses low power, small space, small volume, low weight, and is quiet, and easy to implement. It is quite a challenge for an inner-city hospital to construct and operate a data centre like those built by Google, Amazon, & Microsoft. Current alternatives are either too costly, or exhibit low reliability and/or performance, and none of them achieve the right level of security. In answer to this need, Swiss Vault is developing a high-density, modular genome sequencing/storage proprietary system, which enables organisations to scale their data capabilities in terms of both computing power and storage with high security and low carbon footprint. The BasePort project will allow us to bring to market a data storage hardware integrated with software that operates with 1/10th power consumption, 1/4th volume, and 1/5th weight of conventional comparable systems. The innovative form-factor is 10X more power- & 20X more space-efficient, easy to manage, ideal for Industry 4.0, Smart Cities and Edge computing. Our platform makes data storage a “Green Technology” and enables organizations to reduce their data storage costs and their data-carbon footprint by up to 10-fold. Thanks to this project we will bring to the market the best-in-class solution for storage and management if large data.

Keywords: genomics,security,data storage and management,computation,petabyte,data compression,modular,bigdata,data sequencing,space management
Paradigm Change in Skin Health: Novel Microbiome-based Cosmetics for Acne and Other Skin Conditions (SkinMicrobiome)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Belgium
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-02-01
End date: 2022-01-31
Duration (months): 24.0
Total project cost (EUR): 1856055.0
EU funding (EUR): 1299238.5
Participants: 1
Project status: CLOSED

S-Biomedic has developed a disruptive technology to directly modulate the skin microbiome, enabling a wide range of applications in dermatology. The first product is a cosmetic for acne prone skin (TRL6) with proven efficacy and safety in an area where competing products are either ineffective or cause severe side-effects. Acne is amongst the 10 most prevalent diseases globally and the main reason for people to consult a dermatologist. It affects the life quality of millions of Europeans and represents a market of €4.4 billion. S-Biomedic’s novel skin probiotic product will be launched in 2021 in selected European countries, and will allow reducing current treatments from years to weeks and preventing the actual relapse episodes of acne. S-Biomedic is leading the skin microbiome field based on a unique combination of approach, technology and careful IPR protection. Backed by global industrial partners with an unparalleled reputation in the personal care industries, such as Johnson & Johnson, DSM and Beiersdorf, S-Biomedic has successfully accelerated its R&D and turned its platform technology into a high-potential product pipeline. However, the ambitious challenge posed by the launch of a new cosmetic product in the market can only be met to its full potential with the support of the EIC pilot. The SkinMicrobiome project will support S-Biomedic in the route to market and accelerate its growth, enabling sales >€55M by 2028, positioning it among the Top 10 acne brands globally, with a projected market share of 2,58%. SkinMicrobiome will allow to hire employees with commercial and marketing background, who will complement a multidisciplinary team led by excellent business and scientific professionals. SkinMicrobiome will become a key cornerstone for the successful launch of the first highly innovative cosmetic and will enable S-Biomedic to lead at the forefront of microbiome-based solutions not only in Europe but also on a global level.

Keywords: skincare,skin,microbiome,microbiota,acne,health,probiotic,cutibacterium acnes
European Futures for Energy Efficiency (EUFORIE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Robust decision making and public engagement
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Finland
Call: Socioeconomic research on energy efficiency (H2020-EE-2014-2-RIA, 2014)
Start date: 2015-03-01
End date: 2018-11-30
Duration (months): 45.0
Total project cost (EUR): 1092500.0
EU funding (EUR): 1092500.0
Participants: 4
Project status: CLOSED

The EUFORIE project studies energy efficiency at macro level (EU as a whole and comprison to China), national level (EU-28 Member States), sectoral/company level (selected energy-intensive sectors and companies) and household level, taking into account the perspectives of energy production and consumption. The project uses also participatory foresight workshops to provide new information for energy policy preparation in selected EU Member States. The project has nine Work Packages, the Research/Innovation WPs focus on (1) macro-level analysis on energy efficiency (EU as a Whole and EU-28 Member States; WP2), (2) regional and sectoral case studies on energy efficiency (WP3), and (3) energy efficiency metabolism in socio-economic systems (WP4) by using innovative analysis tools developed by the EUFORIE consortium beneficiaries in previous projects financed by the EuropeanCommisson. Moreover, the project analyses energy efficiency from the consumer perspective (WP5) and energy efficiency development in selected energy-intensive companies by using the previously developed analysis tools (WP6). Last but not least, the project implements a participatory foresight process for energy efficiency stakeholders in selected countries (WP7) and a comparison of energy efficiency in the EU and China (WP8).

Keywords: energy efficiency,decomposition analysis,participatory workshops,eco innovation,advanced sustainability analysis,multi scale integrated analysis of societal and environmental metabolism
Innovative Depalletiser for the automated feeding of signatures in the bookbinding industry. (D-PAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

D-PAL is an innovative depalletiser based on grip technology used for the stacks of signatures handling and feeding the hardcover bookbinding machine in the printing, bookbinding and graphics atrs industry. D-PAL will increase the competiveness of the printing industry by improving the workflows and by saving approx. 3.6% of the printing cost directly related to labour cost for depalletising. D-PAL reduces problems related to the Health and Safety of the workers, is easy to operate and avoids the quality defects due to human error factor due to repetitive tasks. D-PAL is able to depalletise at a speed of 3600-7000 books per hour with high precision, flexibility and versatility. D-PAL is adapted to current methods of automated palletising with paper separators between the layers and is 20% less expensive than competitive solutions. D-PAL has been developed by LARGOIKO S.L.L, a Spanish Mechatronics Engineering enterprise that designs and carries out the automatization of industrial processes, special machines or under demand since 1999. European Union will be also impacted by D-PAL. D-PAL will be 100% manufactured in Europe (Spain) and it will attract foreign capital from USA. D-PAL will have impact in our company, LARGOIKO. We have invested more than €0.4M and we will invest €1.55M more in this project to put into the market D-PAL by January 2019. According to our forecast, we will have revenues of €9,100,000 by year 2023 from sales of our D-PAL depalletiser. The ROI of the project will be 2.60. During Phase 1 execution, we will develop a feasibility study including a business plan to assess the technological feasibility and economic viability. The general aim of D-PAL project is put into the market 8 units of our D-PAL by 2019.

Keywords: depalletiser,printing industry,bookbinding,automated machine
Ladino Proverbs: Edition, Recovery and Dissemination of the Endangered Cultural Heritage in the post-Holocaust Yugoslavia (LadinoProverbs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

This research project will constitute the first peremiological study of the Sephardic tradition from Serbia and Bosnia. Whereas other forms of the Ladino oral tradition from these countries such as ballads, songs or folktales have all been analysed, the proverb tradition remains largely unstudied. Thus my project seeks to fill a serious void in this field. I intend to edit and examine five manuscripts containing proverbs from these countries. All five manuscripts are postHolocaust. Three are exclusively in Ladino, whereas two are bilingual (Ladino/Serbian). The study will entail an analysis of the literary genre of the proverb from an interdisciplinary approach that will include contributions from biblical studies, medieval Iberian cultural studies, modern Balkan history, sociological criticism, linguistics, and folklore paremiology and narrative. The study will also include a cross-cultural analysis of the proverbs using a comparative method. The ultimate goal of this project is a monograph intended to preserve, revitalise and disseminate the endangered Ladino language and culture. Prof. Paloma Díaz-Mas, who works in the Instituto de Lengua, Literatura and Antroplogía (ILLA) of the Centre for Human and Social Sciencies (CSIC, Spain) is the ideal person to supervise my work. She leads a research group that focuses on the culture of post-diaspora of Hispanic Jews (Sephardim) and has an extensive and prominent list of works on the topic published either independetly or in collaboration with other members of the project. By joining her group I would be given the opportunity to [the] acquire new skills (transliteration of Ladino texts written in Hebrew script[s]; edition of texts) and disseminate my work among both academic and non-academic audience through a number of activities (international conferences, workshops and seminars; radio and television programmes; participation in Science weeks and fairs,organisation of exhibitions and promotional talks).

Keywords: sephardim,sephardic jews,ladino,judeo spanish,proverbs,paremiology,folklore,etnography,endangered material,cultural heritage,memory,identity,serbia,bosnia,post holocaust
Enhance New Approaches in BioBased Local Innovation Networks for Growth (ENABLING)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive agri-food sector for a safe and healthy diet
Action type: Coordination and support actions
Countries involved: Italy,Italy,Israel,Austria,Germany,Ireland,Italy,Bulgaria,Norway,Belgium,Belgium,Greece,France,Czechia,Netherlands,United Kingdom
Call: Thematic Networks compiling knowledge ready for practice (H2020-RUR-2017-1, 2017)
Start date: 2017-12-01
End date: 2020-11-30
Duration (months): 36.0
Total project cost (EUR): 1997640.0
EU funding (EUR): 1997640.0
Participants: 17
Project status: CLOSED

ENABLING is the initiative of 16 partners in 13 EU and associated (IL, NO) countries. The main goal is to support the spreading of best practices and innovation in the provision (production, pre-processing) of biomass for the BBI (Bio-Based Industry). In particular, ENABLING aims at creating appropriate conditions for the development of efficient biomass to BBPs (Bio-Based Products and Processes) value chains. The consortium’s vision is that Europe bears a huge potential for optimising the supply of biomass into innovative bio-based processes and products. Upscaling biomass production and pre-processing, and combining streams towards the BBPs with those of more traditional bioenergy chains would enhance at least three interlinked types of impact. a) biomass production gains scale to meet higher demand in both sectors (bioenergy and the BBI); b) the reinforcement of biomass supply for the BBI benefits smaller BBI players, helping them diversify and consolidate biomass input sources; c) reinforcing the biomass and BBPs linkages may contribute to job-creation, due to the increased need for specialised workers. To realise such potential, ENABLING also anticipates its longer term exploitation pathways. In the intention of the consortium, the project should aggregate and engage partners for the establishment of a permanent innovation brokerage platform, likely to become in the future, one of the main marketplaces and innovation transfer accelerators at European level. In this sense, the project organises its work around two building blocks: one relates to animating the stakeholders (on the farming and BBPs sides), identifying best practices, turning them into easy to access content (in the EIP format) for their potential users and providing stakeholders with coaching and guidance on innovation. The other one looks at future developments, with the consolidation, in a self-sustainable way, of the innovation brokerage platforms after the end of the EU funded initiative.

Keywords: bio based products,biomass,agricultural residues
Automated, Fast Generation of High-Performance Instruction Set Simulators for Microprocessors (HIPERSIM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

HIPERSIM is a software platform enabling the fast and automated generation of microprocessor simulators. Using the HIPERSIM platform simulators for virtual exploration, simulation, and verification of microprocessor architectures can be generated within minutes and without the need for programming. The ABIX HIPERSIM concept clearly outperforms conventional, manual development methods for instruction set simulators. It reduces the effort for simulator development and verification drastically, requires only little programming expertise and delivers instruction set simulators with outstanding simulation speed and feature sets.

Keywords: software development tool,simulator tool generator,automatic tool generation,microprocessor simulator,instruction set architecture
Advancing brain research in children’s developmental neurocognitive disorders (ChildBrain)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Belgium,Finland,Hungary,Finland,Sweden,Finland,France,Netherlands,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-03-01
End date: 2019-02-28
Duration (months): 48.0
Total project cost (EUR): 3883795.2
EU funding (EUR): 3883795.2
Participants: 14
Project status: CLOSED

The European Brain Council (EBC) has recommended the disorders of the brain to be prioritised for funding. The purpose of this ChildBrain ETN is 1) to train young scientists, Early Stage Researchers (ESRs), to utilise evidence-based neuroscientific knowledge for helping children, especially those at high risk for dropout due to neurocognitive disorders, to meet future educational and societal demands. The network aims 2) to develop new, innovative brain imaging-based tools through research and industry to be applied by researchers and clinical sector end users for 3) increasing understanding and improving diagnosis and treatment of neurocognitive disorders, as well as enhancing targeted educational programs. To accomplish these goals, we aim 4) to form a cross-disciplinary and trans-sectorial European network of experts. Three research and two training work packages (WPs) are planned to reach these goals. The Childhood neurodevelopmental disorders WP comprises new research and training on the neural underpinnings of dyslexia, ADHD, epilepsy, and hearing loss and creates links to healthcare industry and special education. The Brain development WP will focus on understanding the systems-level brain development at the level of the individual child. The Brain research methods WP will develop new multi-modal data analysis methodologies that are essential for children and will also further brain research in adults. The academic, industrial and private sector partners will work across these themes, offering the ESRs project-specific collaboration, secondments, workshops, summer school and courses on scientific, transferable and entrepreneurial skills, as well as supervision. The ChildBrain ETN will produce a new generation of scientists with the theoretical, technological, and entrepreneurial skills necessary for making breakthroughs in the understanding of brain development and childhood neurocognitive disorders.

Keywords: child,neurocognitive disorder,brain development,dyslexia,adhd,epilepsy,deafness,multi modal brain imaging,dmri,brain connectivity,signal processing,source analysis,modelling