Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integration of PAper-based Nucleic acid testing mEthods into Microfluidic devices for improved biosensing Applications (IPANEMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Israel,Serbia,China,Russian Federation,Serbia,France,France,Netherlands,United States,Portugal
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-01-01
End date: 2025-08-31
Duration (months): 68.0
Total project cost (EUR): 1352400.0
EU funding (EUR): 1352400.0
Participants: 14
Project status: SIGNED

Twelve-member IPANEMA consortium implements competences of participating academic & industry beneficiaries and 3rd country partners to 1) create a knowledge/experience-sharing network of scientists, entrepreneurs & endusers in the multidisciplinary field of biosensors for POCT (point-of care testing); 2) develop innovative bottom-up approaches for fabrication of low-cost POCT devices & implementation of paper-based nucleic acid testing (NAT); 3) pursue applications in 3 important industry sectors – healthcare, agrifood & environmental monitoring. Research & Innovation (R&I) activities will be focused on developing low-cost paper-based isothermal NATs, their integration into microfluidic devices and optimization for use in a) tissue engineering b) agrifood (poultry/plant/fungal) pathogen detection c) detection of toxigenic freshwater Cyanobacteria causing harmful algal blooms. Secondments & trainings will enable researchers to acquire both technical & soft skills needed for converting scientific knowledge & ideas into products & services. Strong involvement of 4 SME partners from Serbia, Israel, France & US contributing their proprietary knowledge on revolutionary novel materials for microfluidic devices & DNA extraction kits, domain expertise in agrifood sector, unique portable sensing systems & handheld devices for isoNAT quantification, will help researchers focus their efforts on development of innovative products for real-life use. Several transducing methods (colorimetric, fluorescence, SPR, electrochemical, microwave & magnetic) and smartphone-based read-out methods will be investigated for POCT use. Renowned beneficiaries including academic INRAE, WU, INESC MN, BGU, UNSPMF & BIOS together with 3rd country academic partners: Columbia University and Xi'an Jiaotong University, will provide transfer of cutting-edge knowledge and technical expertise in effect yielding good basis for long term collaboration and joint R&I projects.

Keywords: microfluidics,biosensors,isothermal nucleic acid amplification,tissue engineering,agrifood,pathogen,toxin,cyanobacteria,environmental monitoring,point of care testing
Enterprise Europe Network Innovation specific services in the two regions of Eastern France (EEN EF4 INNO 20-21)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: France,France,France
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 274335.0
EU funding (EUR): 274335.0
Participants: 3
Project status: CLOSED

EEN EF4 INNO 20-21 aims at delivering specific innovation management services to SMEs and key account management services to beneficiaries of the EIC pilot coaching scheme in the two regions of Eastern France.

Keywords: innovation,innovation management,key account manager,coaching,sme instrument,eic pilot
SOphisticated 3D cell culture scaffolds for Next Generation Barrier-on-chip In vitro moDels (SONGBIRD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-03-31
Duration (months): 63.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

The blood-brain barrier is a sophisticated biological barrier comprising several different cell types, structured in a well-defined order with the task to strictly control the passage of molecules - such as drugs against neurodegenerative diseases - from the blood into the brain. To reduce the ethical and economic costs of drug development, which in EU today uses ~10 million experimental animals every year, we must develop in vitro models of the blood-brain barrier with high in vivo correlation, as these are completely missing today. SONGBIRD aims to achieve this with the scientific approach to - Develop advanced microfabrication methods to handle biologically derived materials - Structure the materials into heterogeneous 3D multi-layer suspended cell culture scaffolds - Incorporate blood-brain barrier cells with precise control on location and order - Integrated the 3D scaffolds into a microfluidic network as a miniaturised screening platform The vision is to develop and validate versatile microfabrication methods to mechanically structure and physically handle soft biological materials to unlock the use of next generation animal-free barrier-on-chip models that can be used to speed up drug development, serve as screening platforms for nanotoxicology and help medical researchers to gain mechanistic insight in drug delivery. During SONGBIRD, I will focus on the blood-brain barrier due to its urgent relevance for drug development for the ageing population but the final processing tool-box will be suitable for realising in vitro models of any biological barrier in the future. SONGBIRD is proposed to run for 60 months and will include researchers with expertise in microsystem engineering (PI), hydrogel synthesis and drug delivery. The expected output is a validated 3D barrier-on-chip model as well as a microfabrication toolbox for biological materials enabling transformation from 2D to 3D cell cultures in several other life science research areas.

Keywords: organs on chip,microfluidics,3d cell cultures,microfabrication
Evolving Language Ecosystems (ELE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Czechia
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 3234000.0
EU funding (EUR): 3234000.0
Participants: 1
Project status: SIGNED

The ELE project will study the foundational principles of programming language evolution and develop practical tools and technologies for supporting the evolution of complete ecosystems. If successful, ELE will drastically decrease the cost of evolution and avoid the need to invent completely new languages every time there is a shift in hardware trends or in programming methodology. Instead, ELE will allow evolution of languages and will support migration of code and knowledge bases. The project proceeds along two major axes. The first axis is language dynamics where new features and new capabilities are added to a preexisting language. This requires changing, at the same time, the language's specification, it's semantics, and the language's implementation, the compiler and interpreter that runs code written in the language as well the runtime libraries that provide basic capabilities. The second axis for evolution is language statics where new rules are added to enforce novel programming disciplines and where existing code artifacts are adapted to new semantics. These axes are not entirely disjoint, as static restrictions, such as a new type system, can feedback into the implementation by providing behavioral information that can be exploited by a compiler.

Keywords: programming languages,compilers,virtual machines,static analysis
BIOSKOH’s Innovation Stepping Stones for a novel European Second Generation BioEconomy (BIOSKOH)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Innovation actions
Partnership: BBI (Art-187)
Countries involved: Italy,Germany,Italy,Switzerland,Belgium,Slovakia,Slovakia,Slovakia,Sweden,Belgium,France,France,Netherlands,United Kingdom,Denmark
Call: From lignocellulosic feedstock to advanced bio-based chemicals, materials or ethanol (H2020-BBI-PPP-2015-1-1, 2015)
Start date: 2016-06-01
End date: 2022-05-31
Duration (months): 72.0
Total project cost (EUR): 30122313.75
EU funding (EUR): 21568194.13
Participants: 19
Project status: CLOSED

The BIOSKOH project will pave the way for a Second Generation European Circular Bioeconomy by showcasing how a number Innovation Stepping Stones can realise a breakthrough in techno-economic viability of lignocellulosic biorefineries. It will do so through a two stage investment process and development path to realise the largest (110 kton) second generation (2G) biorefinery in Europe. It starts from a brownfield industrial site in the eastern part of the Slovak Republic to realise the 1st stage Flagship plant to produce 55 kton of cellulosic ethanol per year for EU bio-fuel mandates. Partners include the full value chain starting from land owners and feedstock producers, supply chain experts and an agronomical research partner to set-up a new biomass value chain exploiting large amounts of currently unused crop residues (kton/year), and developing newly grown dedicated crops on marginal land (total circa 320 kton/year), as such revitalising the regional economy. Technology providers (Biochemtex, Novozymes and Lesaffre) developed, tested and demonstrated in the only available semi-industrial scale 2G biorefinery research plant, an innovative integrated pre-treatment, hydrolyses and fermentation package, with higher yield and lower CAPEX which will now be upscaled to the 1st of a kind commercial scale Flagship, to be built by Energochemica. Aim is to showcase techno-economic viability based on a sound business plan and 4 stepping stones (yield, biomass cost, brownfield and industrial symbiosis). Dedicated innovation actions by expert partners include assessing increased cascading potential through lignin valorisation and 2G bio-chemicals, LCA, Socio-economic impact analyses, business plan for a 2nd investment round, exploitation, dissemination and replication actions to various bio-economy clusters in Europe, thus giving both a short term and a long term contribution to the European Industrial Renaissance and bio-economy.

Keywords: bioeconomy,biorefinery,ethanol,second generation,cascading approach,biomass,flagship
Drivers of Pontocaspian biodiversity RIse and DEmise (PRIDE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Germany,Ukraine,Azerbaijan,Germany,Romania,Russian Federation,Türkiye,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-03-01
End date: 2019-02-28
Duration (months): 48.0
Total project cost (EUR): 3784088.6
EU funding (EUR): 3784088.6
Participants: 17
Project status: CLOSED

Since the 1930s, the unique endemic aquatic biota of the Caspian-Black Sea region is facing a biodiversity crisis as it is severely affected by anthropogenic activities such as habitat destruction, invasive species and pollution. Understanding long-term natural biotic and abiotic drivers of lake system change and biotic response to perturbations in the past 2 Ma – i.e. gradual, rapid and/or threshold responses – is absolutely necessary to assess the current response of Pontocaspian biota to rising natural- and human-induced perturbations. The Pontocaspian example mirrors the complex global ecological and biodiversity challenge due to Global Change. This challenge can only be addressed through an integrated cross-disciplinary research involving climate, earth- and bio-sciences. PRIDE (Pontocaspian biodiversity RIse and DEmise) is a fully integrated academia-industry training network of scientists with complementary cutting-edge competences. PRIDE focuses on the evolution of Pontocaspian biota over the past 2 million years. The extraordinary endemic biodiversity, coupled with a high-amplitude record of palaeoenvironmental change, makes it an ideal system to study drivers of past and current biodiversity crises. By linking Pontocaspian palaeoenvironmental and biodiversity changes we will reconstruct biological resilience to environmental change and apply this knowledge to the current Pontocaspian biodiversity crisis to model future diversity shifts under different Global Change scenarios. PRIDE will provide outstanding interdisciplinary technical training, new skills acquisition and career development for 15 early stage researchers. An innovative outreach plan will deliver our results to stakeholders and the public. PRIDE results from existing, successful collaborative relationships and will expand to include 17 first-class private and academic geological and biological institutions allowing Europe to remain world-leading in integrated studies of biodiversity change.

Keywords: biodiversity turnover drivers resilience quaternary pontocaspian
INDUSTRIALIZATION OF BIOBASED TEXTILE FABRICS FOR CLOTHING APPLICATIONS (FIBFAB)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Spain,Türkiye,Belgium,Belgium,Czechia
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-09-30
Duration (months): 33.0
Total project cost (EUR): 1447689.92
EU funding (EUR): 1266296.45
Participants: 5
Project status: CLOSED

FIBFAB project aims to industrialize and launch successfully the production of biodegradable and sustainable polylactic acid (PLA) based fabrics (wool/PLA and cotton/PLA) for the applications in casual (men and womenswear), protective and workwear clothing, and to overcome current limitations of PLA fibres as real alternative to current fabrics (wool and cotton with polyester fibres). Main FIBFAB project innovations are: - To obtain a final clothing product 100% bio-based and biodegradable that meets the mechanical and performance requirements of the textile sector - To improve the current poor thermal resistance of PLA fibres to meet the requirements in several clothing applications by adding additives to enhance the final PLA crystallinity. - To improve the extrusion process for PLA fibres and especially the mechanical spinning process -To introduce in the textile market yarns and fabrics produced from PLA fibres combined with cotton or wool.

Keywords: fibres,compounds,yarns,clothing,sustainable,cotton,wool
Supporting EU-African Cooperation on Research Infrastructures for Food Security and Greenhouse Gas Observations (SEACRIFOG)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Coordination and support actions
Countries involved: Germany,Ireland,South Africa,Germany,Germany,Italy,Germany,Norway,Sweden,Finland,Namibia,Czechia,Ghana,Cabo Verde,Kenya
Call: Policy and international cooperation measures for research infrastructures (H2020-INFRASUPP-2016-1, 2016)
Start date: 2017-03-01
End date: 2020-08-31
Duration (months): 42.0
Total project cost (EUR): 1999890.0
EU funding (EUR): 1999890.0
Participants: 18
Project status: CLOSED

African societies face growing global change risks, with rapidly changing patterns of human settlements and intensity of use of ecosystem services. At the same time, climate variability and climate change trends are intensifying stress on the ecosystems that ensure environmental security, both locally (e.g. ecosystem services), regionally (e.g. sustainable development options) and internationally (e.g. carbon sequestration). Approaches that can address this challenge in an integrated and multidisciplinary way are urgently needed in many places in Africa where there is a close relationship between societal well-being and environmental condition, relating particularly to biomass for energy and food production, and hydrological considerations such as water yields. Policymakers and land-use decision makers are increasingly dependent on knowledge on the state of the environment. Long-term observational systems and research infrastructures have been identified to be indispensable elements of knowledge generation to serve climate change adaptation, food security, and climate change mitigation. This proposal supports EU-African cooperation on research infrastructures. Its aims are to increase coherence and interoperability between infrastructures in Europe and Africa, to enhance technical competence, science awareness and life-long learning in Africa in order to facilitate the use of research results for evidence-based policy making, and to identify knowledge gaps for future research directions. The project will 1) identify the essential parameters needed to develop science based strategies to improve food and nutrition security including early warning systems and to mitigate climate change, 2) formulate a roadmap towards fully interoperable and accessible research infrastructures in agricultural and climate research in the EU and Africa that match the needs of the users, and 3) deliver a contribution to capacity building and human capital development in Africa.

Keywords: eu africa,research infrastructures,food security,greenhouse gas observations,interoperability
International Interdisciplinary PhD studies in Biomedical Research and Biostatistics. Supporting the career and training in omic-based research and biostatistics by inter-national and-sectoral mobility (ImPRESS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,Iceland,Germany,Austria,Belgium,Poland,Poland
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2016, 2016)
Start date: 2018-02-01
End date: 2023-01-31
Duration (months): 60.0
Total project cost (EUR): 3139200.0
EU funding (EUR): 1569600.0
Participants: 11
Project status: CLOSED

The aim of the project is to launch Interdisciplinary PhD Studies in Biomedicine aimed at young aspiring scientists, who will conduct research on life-style diseases and on biostatistics and bioinformatics methods necessary to process and interpret data obtained in research projects. The studies will provide an outstanding opportunity for in-depth education in high-throughput experimental and computational techniques used in genomics, proteomics, metabolomics and immunology. 15 PhD students will be involved in scientific projects supervised by excellent researchers, outstanding scientists selected from partner organizations, with a profound expertise and experience in: Cancer/Mutagenesis, Cardiovascular diseases, Population Medicine and Epidemiology, Diabetes/Obesity, Metabolic and Neurodegenerative diseases, Regenerative medicine, Molecular Biology, Genomics, Protein Analysis and Proteomics, Metabolomics/Lipidomics, Immunology and Experimental Medicine. They will be employed at Medical University of Bialystok. The development of doctoral students' research potential will be based also on internships, short research visits, conferences and trainings at the partner institutions: CEMBIO San Pablo University, Vienna Biocenter, Spanish National Center for Cardiovascular Research CNIC, Bialystok University of Technology and CenStat at Hasselt University. Industry partner organizations: Agilent Technology, deCODE, ideas4biology and Warsaw Genomics will invite PhD students for scientific visits, to familiarize young researchers with the tools and methods of work and organizational environment in the company. Industry providing their know-how will educate, and prepare their potential employees with high qualifications to get job in the close future. Best young scientists from the beginning of their academic career will be able to gain scientific independence and will have huge motivation to become more involved and creative in the research projects carried out thanks to COFUNDing the project by EC.

Keywords: phd studies,biomedical research,biostatistics,bioinformatics,omics,research projects,international,interdisciplinary,intersectoral
Excel in Rare Diseases’ Research: Focus on LYSOsomal Disorders and CILiopathies (LYSOCIL)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Italy,Portugal
Call: Twinning (H2020-WIDESPREAD-05-2017-Twinning, 2017)
Start date: 2018-11-01
End date: 2022-04-30
Duration (months): 42.0
Total project cost (EUR): 967572.5
EU funding (EUR): 967572.5
Participants: 3
Project status: CLOSED

The high diversity, low numbers and scattered distribution of patients affected rare diseases (RDs) represent a big challenge for biomedical research and health care, the patients and their families. International cooperation is paramount to understand the etiology and find better diagnostic procedures for RDs. LYSOCIL addresses that need through a scientific strategy to reinforce research and innovation excellence in the study of lysosomal diseases and ciliopathies, with a special attention on the diagnosis and etiology of these diseases. The Chronic Diseases Research Center of the NOVA Medical School (UNL-NMS-CEDOC) aims to be at the forefront of European and international scientific excellence in chronic RDs. Towards this goal, UNL-NMS-CEDOC is twinning with two internationally leading research institutions, the Münster University (WWU) and the Telethon Institute of Genetics and Medicine (TIGEM - FTELE.IGM). LYSOCIL will leverage on WWU and TIGEM’s outstanding multidisciplinary knowledge and experience, research and training best practices, as well as collaborative networks to enhance the research capacity and innovation potential of CEDOC-NMS. LYSOCIL is an integrated network of interactions (exchange and training of researchers, satellite meetings, Winter Retreats, virtual think tanks, etc.), articulated with the individual and joint scientific agendas of the partners, to power the research capacity of CEDOC-NMS and of its local and national ecosystems. LYSOCIL expects to increase by 20% in multiple indicators by 2021, including the number of citations; h-index of UNL-NMS-CEDOC researchers; percentage of publications in top impact journals; number of international collaborations and publications. By stimulating novel and long-lasting interactions between UNL-NMS-CEDOC, WWU and TIGEM (FTELE.GM) l unlock the research potential within and outside CEDOC-NMS, with an overall increase in the Portuguese and European RD research competitiveness.

Keywords: rare diseases,chronic disease,ciliopathies,lysosome related organelles,cilia