Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Highly Accurate Molecular Properties using variational Quantum Electrodynamics (HAMP-vQED)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: France
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1929658.0
EU funding (EUR): 1929658.0
Participants: 1
Project status: SIGNED

Quantum chemical calculations are today in a position where they not only assist, but may also challenge experiment, at least for molecules containing light atoms only. When heavy atoms are present, achieving the same accuracy becomes more challenging, not only because of relativistic effects, but also because the larger number of electrons and the often complicated electronic structures make the electron correlation problem harder. When surveying the physics that has to be included in order to establish a reliable computational protocol for heavy-element chemistry, the role of quantum electrodynamics (QED) should at least be considered. Studies so far indicate that QED-effects reduce relativistic effects by about 1%. However, such investigations have been mostly limited to valence properties, since there are currently no reliable tools for general molecules to study the core region where the QED-effects are generated. The HAMP-vQED project aims to fill this gap by providing a computational machinery allowing highly accurate calculations of molecular properties, with particular focus on properties that probe electron density in the core region, such as NMR parameters. I insist on a variational approach to QED using the local, finite basis sets of quantum chemistry. In short, I want to do QED without diagrams. This allows me to verify the domain of validity of currently used effective QED-potentials and provide a more consistent formulation of relativistic quantum mechanics. QED has been called the last train from physics to chemistry. The HAMP-vQED project provides a train back to physics in the form of highly accurate calculations which, combined with experiment, will allow the exploration of nuclear structure, the standard model of the universe and beyond. An even more tantalizing perspective is that such a variational scheme to QED may inspire progress in other quantum field theories, such as quantum chromodynamics, where perturbation theory is more problematic.

Keywords: relativistic molecular calculations,molecular properties,quantum electrodynamics,coupled cluster theory
Uncovering the machinery for the sorting of newly synthesized proteins into the axon (NEUROSORTER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Neuronal development and function rely on the polarized distribution of organelles and transmembrane proteins (cargoes) across their somatodendritic and axonal domains. However, it is unknown how organelle organization regulates the polarized sorting of transmembrane proteins to ensure proper neuronal function. The classical model for sorting of newly synthesized transmembrane proteins to the plasma membrane (PM) follows the biosynthetic pathway via the rough endoplasmic reticulum (ER) and Golgi, which are restricted to the somatodendritic domain in neurons. It is unclear whether this classical secretion pathway is the main route for cargo sorting into the axon or whether an alternative route to the axon is used for most axonal cargoes. Intriguingly, evidence indicates that cargoes can bypass the Golgi for their sorting to the axonal PM. However, the identity of an unconventional secretory pathway has not been demonstrated yet. Here, I propose that selective machinery, including the axonal ER and undefined intermediate compartments, allows local axonal cargo secretion. Previously, I advanced our knowledge on Golgi-dependent sorting of somatodendritic cargoes and elucidated the mechanisms behind ER organization in neurons. Here, for the first time we will: 1) Identify the sorting routes for newly synthesized axonal proteins 2) Unravel the machinery required for Golgi-independent cargo sorting into the axon, and 3) Elucidate its impact on neuronal development and function We will use high spatio-temporal resolution imaging and mass-spectrometry combined with novel strategies to control and track cargo secretion, as well as proximity-based labeling to identify key players in the newly identified machinery. A broad spectrum of human diseases is associated to cargo Golgi-bypass. Neurons offer a unique advantage in spatial resolution to characterize this unconventional route, which could play a key role in human health and disease.

Keywords: neurons,neuronal development,polarized sorting of transmembrane proteins,classical biosynthetic pathway,unconventional sorting,golgi bypass,endoplasmic reticulum
Youth for Space Challenge - ODYSSEUS II (Odysseus II)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Coordination and support actions
Countries involved: Austria,Italy,Spain,Germany,Belgium,Greece,Poland,Belgium,France,Czechia,Denmark,United Kingdom
Call: Outreach through education (H2020-COMPET-2014, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 2076788.13
EU funding (EUR): 1994376.0
Participants: 15
Project status: CLOSED

The Youth for Space Challenge - ODYSSEUS II project aims to inspire young people from all over Europe and to engage them in space exploration, through a series of educational activities, which will combine scientific learning with hands-on experiences. Through the organization of a fun oriented educational contest, which will be organized in multi rounds and which will target all pupils and students in Europe, wherever they are living and irrespective of their cultural background and the language they speak, the project will foster the development of qualified scientists, engineers and technicians in areas relevant to the priorities of the EU space policy. Besides the objective of providing the Space challenge to young people, the Odysseus II project will also strive to foster international collaboration and to attract attention to the field of science education related to space exploration. In this respect, the objective of the project is to involve national educational authorities and to engage with space industries and many science centres and space agencies across Europe on the exchange of experiences and knowledge on learning programmes about space exploration. Participation in the Odysseus II contest will be used as a good benchmark and indicator of how well space science and technology is accepted and integrated into the curriculum of different educational systems across the EU. Since educational competitions in general enjoy broader acceptance, the Odysseus II contest will also provide the opportunity to space industry and national educational authorities to show their support to educational activities related to space.

Keywords: education and public outreach,contests,national space activities,hands in science,coordination of educational initiatives
Sonar INtegrated Advanced NavigatioN (SINANN)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Ireland
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2014, 2014)
Start date: 2015-03-01
End date: 2015-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

SINANN will leverage the identified capability of SonarSim’s high-performance Computational Ocean Acoustics framework to unlock a tangible 10-15% efficiency improvement in coastal zone seabed survey operations. The resulting productivity step change could potentially double the profit margin of a typical survey vessel, an expensive capital investment costing a minimum of €10 million per annum to operate. A significant portion of operational survey time is wasted collecting redundant seabed data and correcting routine errors caused by the inherent deficiencies in traditional manual based vessel path planning and swath coverage prediction processes. SINANN enables end users to identify the optimal fit for purpose survey configuration pre-survey, predict expected seabed survey performance analytics, and execute the optimal survey strategy in the field through smart high performance computerised solutions. Target end users are blue chip survey organisations involved in National charting, offshore oil and gas, marine renewable energy, and subsea telecoms.

Keywords: multibeam,sonar,hydrography,navigation
Creating effects through communication and engagement in Future and Emerging Technologies (EFFECT)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Italy,Spain,Italy,Belgium
Call: FET-Open Coordination and Support Actions (H2020-FETOPEN-2-2016, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 499937.5
EU funding (EUR): 499937.5
Participants: 4
Project status: CLOSED

The aim of the 24-months EFFECT project is (1) to enhance visibility and impact of FET research among a wide variety of actors - researchers, industry, policy makers, civil society organisations, citizens and students - and (2) to stimulate debate and collaboration among multiple stakeholders through dedicated community building and public engagement activities. EFFECT proposes an innovative and customized communication model that will be implemented by: i. screening sources, research projects and results on FET from FP7 and H2020, under the guidance of a scientific Advisory Board; ii. develop and distribute customized contents in different communication formats and channels through web, social and TV media; iii. stimulate public debate, collaborative learning, networking and engagement among multiple players of the FET domain through R& I infodays and brokerage events; policy-oriented workshops; webinars aimed to the on-going FET funded projects; general public engagement campaigns (European Researchers’ Night); iv. monitor the efficacy of the distribution mechanisms, measure and assess the overall generated impacts and elaborate a set of recommendations fostering the development of successful communication campaigns on FET. Customized synergies will be sought with on-going FET projects such as FET Flagships, FET ERANETs and FET CSAs, as well as European NCP Networks and Enterprise Europe Network. EFFECT dynamic and inclusive engagement methodology, as well as its broad and integrated approach on communicational content definition and distribution will improve transfer knowledge, increase awareness, enhance interaction with a larger public, promote dialogue among different target groups and foster the emergence of an innovation ecosystem around future and emerging technologies.

Keywords: media commnuication,social media,staleholders relations,public awareness,outreach,citizen engagement
Airflow characterization through rotating labyrinth seal (AIRSEAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Romania
Call: Airflow characterization through rotating labyrinth seal (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-03-01
End date: 2022-11-30
Duration (months): 45.0
Total project cost (EUR): 547500.0
EU funding (EUR): 547500.0
Participants: 2
Project status: CLOSED

The main objective of this project is to test different labyrinth seal configurations (15 geometries of the labyrinth and 5 axial position between the rotor and stator) to determine the pressure loss characteristics for different rotor speeds, radial clearances and at different temperature and pressure ratios. The test rig, specifically developed in this project, will be able to test a seal configuration in a simplified environment. The tests will be divided in two campaigns, the complexity of the second campaign being dependent on the results and conclusions of the first. The results of the tests will be compared with the prediction of a numerical model in order to perform a gap analysis. The final expected result is that the experimental measurement to match the numerical results. If the experimental data does not match with the numerical results, then improvements will be made to the numerical model.

Keywords: low pressure turbine,labyrinth seal testing,radial clearance,data processing,design of experiments
Stepping Up mRNA Mutanome Immunotherapy (SUMMIT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-08-01
End date: 2023-07-31
Duration (months): 60.0
Total project cost (EUR): 2482500.0
EU funding (EUR): 2482500.0
Participants: 1
Project status: SIGNED

Immunotherapy is expected to fundamentally change the treatment of cancer patients. Personalized vaccines eliciting immune responses against individual cancer mutations have moved into the spotlight. We have pioneered the field and moved ´cancer mutanome vaccines´ from a mere vision into a disruptive medical concept compatible with current standards of drug development and health care practice. Solving key scientific and technological challenges and building on extensive preclinical studies, we showed in a first-in-human trial potent tumor-directed immunity in every single vaccinated patient, and clinical activity of a novel mRNA-based mutanome vaccine. Given that mutations are a hallmark of cancer, mRNA mutanome vaccines are universal drugs the efficacy of which are unaffected by the cancer type. The aim of this proposal is to ignite the next wave of advancement by addressing four key constraints challenging a full clinical realization of such vaccines. We will address the scarcity of point mutations in many tumors by extending neoepitope discovery to the full spectrum of genetic aberrations. Cancers are heterogeneous and outgrowth of clones unaccounted for by the vaccine is an efficient escape mechanism. We will develop neoepitope prediction algorithms deciphering clonal heterogeneity to inform rational vaccine design and countermeasures against selection of target escape variants. Tumor cell resistance to vaccine-induced T cells due to antigen presentation defects will be addressed by developing strategies for mobilizing the full repertoire of immune effector mechanisms, including antibodies and NK cells. T-cell exhaustion will be tackled by vaccination protocols promoting long-lived memory responses and by combination treatments counteracting tumor-mediated immunosuppression. Finally, we will drive the seamless clinical translation of the scientific findings by close interdisciplinary collaboration with strong and established clinical and industrial partners.

Keywords: precision medicine,personalized cancer vaccines,neoepitope prediction,cancer mutanome,immune escape,tumor heterogeneity
Augment your pension - How Augmented Reality (AR) can improve future financial well-being: The role of future self-imagery and its impact on pension awareness and engagement (AUGMENTPENSION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2024-04-02
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: SIGNED

Elderly poverty is a prominent problem, and financial well-being in elderly is often considered low. A common cause for elderly poverty is a lack of sufficient pension awareness and engagement, especially at a young age. Independent of the pension scheme in a particular country, pension funds and policymakers around the world struggle to increase the engagement of pension plan consumers that would affect a consumer's future financial well-being positively. An often-proposed intervention to overcome the present bias that leads to not engaging with pension communications is to stimulate the imagery of the future self in pension plan consumers. Yet, current pension communications fall behind expectations in stimulating imagery of the future self and thus fail to improve pension awareness and engagement. In light of recent evidence on a new technology coined Augmented Reality (AR), this project proposes an experimental approach to investigate the impact of AR on the imagery of the future self and the downstream effects on pension awareness and engagement. Building on a series of laboratory, online, and field experiments, I apply findings from recent AR research in consumer behavior to find evidence and theoretically explain the effects AR can have on pension awareness and engagement. Combining findings from laboratory studies with field-evidence from the world’s third largest pension provider (APG) will shine light on how to improve pension communication with AR to improve future financial well-being. The proposed results are societally relevant as they can help to promote pension engagement that results in future financial well-being. My strong background in experimental consumer behavior research with a focus on AR technology and consumer engagement, combined with my supervisor’s expertise in pension and financial well-being research, and the strong research and training environment at Maastricht University (UM) will guarantee a successful project completion.

Keywords: consumer behavior,financial well being,pension awareness,pension engagement,augmented reality ar
Bulk Photovoltaic effect via Wannier functions (PhotoWann)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

PhotoWann aims to shed light into the exceptional properties related to the bulk photovoltaic effect (BPVE) - a nonlinear absorption process - of cutting edge materials like Weyl semimetals, whose photocurrent has very recently been measured to reach colossal values. Thanks to a newly developed method, the track record of the applicant and the expertise of the Host in this field, we are in a privileged position for quantitatively accessing the structure of the BPVE that emerges from narrow k-space regions surrounding the Weyl points, hence shedding light into the breakthrough experimental measurements as well as proposing novel ones. As an additional major goal for the project, we will perform a combined theoretical-experimental investigation (secondment) with the group of T. Neupert in UZH Zurich for analyzing the beta phase of GeSe, a newly synthesized 2D material that is expected to show unconventional nonlinear absorption properties thanks, among other features, to its unusually large electronic density of states, making it a realistic candidate for future applications. In parallel with these two major objectives, we plan to undertake yet another ambitious goal, namely the development and implementation of a robust and efficient computational algorithm for the calculation of the various properties related to the BPVE within the well-established free-software package WANNIER90. This will undoubtedly benefit a substantial part of the scientific community in this field, as it will turn the up-to-now cumbersome and almost prohibitive calculation of this type of processes into a fairly routine task. Our work will therefore generate a fundamental and systematic understanding of nonlinear physics of solids not only through our particular investigations, but also from many other researcher's via the developed and shared computational algorithm.

Keywords: ab initio methods,wannier functions,density functional theory,bulk photovoltaic effect,shift current,topological physics,weyl semimetals,2d systems,semiconductors