Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
integrated nano-photonic OMICs bio-SENSor for lung cancer (OMICSENS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Italy,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 24.0
Total project cost (EUR): 581352.5
EU funding (EUR): 581352.5
Participants: 2
Project status: CLOSED

OMICSENS aims to fabricate a radically innovative nanophotonic multi-omics biosensor that will be applied to improve non-small cell lung cancer (NSCLC) prognosis and treatment outcome through discovery and identification of drug resistance biomarkers. To achieve this overarching goal, OMICSENS pioneers the development of a label-free optical technology using all-dielectric nanostructured metasurfaces functionalized with biomimetic lipid membranes that enable near infrared (IR) light detection of relevant biomarkers (i.e., nucleic acids, proteins, small molecules and extracellular vesicles), with unprecedented sensitives, in quasi real time. The addition of the deep-tech SME - Cellularis Biomodels (CEBIOM), as the widening partner in the OMICSENS project will be pivotal for the optimization and validation of nanophotonics biosensor platform and computational analytic pipeline as it will provide relevant biological samples (i.e., secreted protein, DNA/RNA, extracellular vesicles) derived from EGFR mutated patient-derived 3D tumor tissues as a complement to those solely obtained from 2D cancer cell line cultures. Gathering on CEBIOM previous expertise and proprietary cancer models technologies, the widening partner will bioengineer innovative patient-derived ECM-tumor-stroma organoid models that recapitulate NSCLC hallmarks and its EGFR mutational signatures. The Organoid-on-Capsule model will allow for continuous proteins secretion from tumoroids into culture medium, enabling both discrete or real time analytics of biomarkers on-chip. Compartmentalization in hydrogel capsule units will also allow for concentrating secreted EVs from tumor organoids across different time scales in vitro. Overall, CEBIOM will upgrade OMICSENS activities while contributing for reducing the potentially necessary use of animal tumor models to complement biosensor validation, being in line with EMA 3R’s legislation and the EU-wide Action Plan to phase-out animal models use.

Keywords: non small cell lung cancer cancer biosensor organ on chip omics metamaterial machine learning
Safe Wheat Agriculture Towards Sustainable Health: Innovative Sensing Techniques, and Holistic Spectroscopy Traceability for Improved Soil, plant Health and safe wheat grain (WHEATWATCHER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Innovation actions
Countries involved: Belgium,Germany,Estonia,Greece,Poland,Switzerland,Israel,Czechia,Lithuania
Call: Onsite digital technologies to monitor nutrients and chemical or biological stressors in soil and plants with relevance for food safety and nutrition (HORIZON-MISS-2023-SOIL-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 6277335.0
EU funding (EUR): 5967116.25
Participants: 15
Project status: SIGNED

In a world grappling with complex global challenges such as population growth, climate change, and environmental degradation, ensuring security, sustainability, and food safety is paramount. Agricultural practices and food production processes are integral to public health, economic stability, and societal well-being. However, conventional approaches have often operated in isolation, limiting our understanding and hindering scalability. The WHEATWATCHER initiative seeks to break these barriers by uniting soil health monitoring, plant health assessment, and food traceability through a cutting-edge digital soil monitoring system. This system assesses soil nutrition, chemical, and biological factors impacting wheat grains from field growth to flour production, spanning multiple European regions. By actively involving stakeholders, including farmers, mill proprietors, and policymakers, WHEATWATCHER tailors its solution to practical needs. It leverages diverse sensor technologies, advanced machine learning models, and automated mapping techniques to boost efficiency and scalability. A Decision Support System and cloud platform ensure accessible insights. At its core, a machine learning model seamlessly integrates technologies, creating a cohesive solution that bridges the gaps between soil health, plant health, and food traceability. WHEATWATCHER aims to foster harmony between sensing technologies, data processing, and stakeholder engagement, revolutionizing comprehensive monitoring.

Keywords: sensing technologies remote,proximal
Integration through rights in a European Society? A new theory on the role of law for integration within and beyond a fractured EU (RIGHTS-TO-UNITE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Ireland
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2498916.0
EU funding (EUR): 2498916.0
Participants: 2
Project status: SIGNED

Among the many crises of the European Union (EU), the fracturing of its promise to integrate the emerging European society peacefully through law represents a fundamental one. At the time of writing, martial conflict and pressure through economic sanctions are once again relied upon to assuage conflict in the EU’s neighbourhood, while the authority of EU law has been challenged by several Constitutional Courts, most recently by the Romanian and the Polish supreme courts in December and September 2021. The question thus is: can the EU still rely on the integrative capacity of its law? RIGHTS-TO-UNITE addresses this question by placing citizens’ practical usage of substantive EU-derived rights at its centre. It conceptualises rights as claims between citizens as well as between citizens and states and the EU itself. European integration is defined as a process combining citizen into a coherent, though diverse, society. This approach captures whether and if so, how integration through rights can succeed in a multipolar society constituted by European Union law, both in the EU and its neighbourhood, while also specifying conditions which are supportive and averse to achieving integration of the emerging European society. After theorising conditions for EU-derived rights to integrate the emerging European society in the EU and its neighbourhood, qualitative comparative research is deployed to identify to what extent EU derived rights are part of Europe’s living law in the EU and beyond. The qualitative research develops an innovative methodology comprising interactive vignettes visualising scenarios in which EU economic, social, and digital rights could be relevant. This enables cross-cultural exploration of citizens’ everyday experience with EU derived rights. In a final step the results are synthesised in a socio-legal theory of integration through rights for the context of the EU and its neighbourhood.

Keywords: integration through rights,european society,eu citizens rights,eu neighbourhood,european integration,differentiated integration,variegated geography
Structural Health Monitoring of Hydrogen Composite Overwrapped Vessels (SHyCOV)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,United States,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2029-07-31
Duration (months): 42.0
Total project cost (EUR): 473121.9
EU funding (EUR): 473121.9
Participants: 4
Project status: SIGNED

Hydrogen energy is a promising component of a sustainable future, though its extensive adoption is challenged by issues in storage and transportation. Composite Overwrapped Pressure Vessels (COPVs) have emerged as a promising solution due to their superior strength-to-weight ratio and corrosion resistance. However, maintaining the structural integrity of COPVs under the demanding conditions of hydrogen storage remains a major concern. Micro-damages and operational impacts can compromise the safety and lifespan of these vessels, yet there is currently no standardized EU-wide methodology for in-service condition assessment. The SHyCOV project (Structural Health Monitoring of Hydrogen Composite Overwrapped Vessels) addresses this critical gap by developing an advanced Structural Health Monitoring (SHM) system tailored for COPVs. This project is timely given the anticipated growth of hydrogen infrastructure in Europe and the crucial role COPVs will play in this transition. SHyCOV employs a multi-disciplinary approach, integrating advanced ultrasonic wave propagation modeling, experimental testing, and innovative sensor technologies to detect and localize damage within COPVs. The outcome will be a cost-effective, real-time monitoring system that extends the lifespan of hydrogen storage vessels and prevents potential catastrophic failures. By bridging a significant gap in current EU standards and ensuring the safe deployment of hydrogen energy, SHyCOV will enhance scientific knowledge and facilitate the broader adoption of hydrogen as a clean energy source. The project also provides researcher with essential skills in assessing structural damage in hydrogen composite vessels, positioning him as a leader in this innovative field. SHyCOV’s SHM solution holds considerable commercial potential, supporting future industrial applications and aligning with global initiatives to reduce carbon emissions and transition to sustainable energy.

Keywords: composite pressure vessels,structural health monitoring,non destructive testing,hydrogen storage safety
Sustainable Urban Net Zero Network for Ukraine (SUN4Ukraine)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Climate neutral and smart cities
Destination: Climate neutral and smart cities
Action type: Coordination and support actions
Countries involved: Belgium,France,Ireland,Finland,Ukraine,United States,Italy,Netherlands,Türkiye,Poland
Call: Associating Ukrainian cities to the Climate-neutral and smart cities Mission (HORIZON-MISS-2023-CIT-02, 2023)
Start date: 2024-05-01
End date: 2028-04-30
Duration (months): 48.0
Total project cost (EUR): 4999605.0
EU funding (EUR): 4999605.0
Participants: 18
Project status: SIGNED

SUN4Ukraine aims to bring together Ukrainian cities with the EU 100 Climate Neutral and Smart Cities Mission, through capacity building, technical expertise, twinning, multi-level governance and policy to support them in adopting climate neutrality targets and incorporating climate neutrality into reconstruction plans. SUN4Ukraine will select and work closely with 10 Ukrainian frontrunner cities who will receive technical support and participate in a capacity building programme to develop Climate Neutrality Plans, aiming for climate neutrality by 2050. A needs assessment will be undertaken to understand the specific needs of each of the frontrunners informing detailed design of support. Technical support will guide frontrunners through the process of setting targets and the gap to be filled, identifying mitigation actions, engaging citizens and establishing new governance, designing Climate Neutrality Plans, and funding/financing their implementation. Connections with funders and financiers will also be made to facilitate implementation. The capacity building programme will build the skills and capabilities of frontrunners, and include at its core, the peer learning, exchanges and study visits of frontrunners to Mission cities. A Ukrainian Cities Climate Hub will be established to bring frontrunners and other Ukrainian cities together to encourage mentoring, ongoing partnerships and replication. The lessons learned from technical support and the capacity building programme will be synthesised into guidance made available via the Hub and Mission Platform. Policy dialogues and recommendations, and good practices on multi-level governance will be developed to ensure Ukrainian cities can become climate neutral by 2050. A targeted communication and dissemination strategy will complement and support implementation. SUN4Ukraine will bring increased visibility to the Cities Mission and achieving its second objective of all European cities becoming climate neutral by 2050.

Keywords: cities mission,climate neutrality plans,climate neutrality targets,sustainable rebuilding of ukraine,climate neutrality,citizen engagement,twinning,capacity building,peer learning
The Cost of Stigma: Tackling and Responding to Discrimination Against Students in the Sex Industry within Spanish and Italian Universities (COSTI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Mexico,Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 280513.2
EU funding (EUR): 280513.2
Participants: 3
Project status: SIGNED

Global challenges in fostering university education free from discrimination are on the rise. Many students face bias based on their class, gender, race, age, or occupation, often without recognition of their rights. While European universities have made significant progress in preventing gender-based violence against women and the LGBTQ+ community, they have yet to address discrimination against students in the sex industry. This issue is increasingly relevant as more students turn to sex work due to rising tuition fees and living expenses. COSTI aims to fill this gap by promoting equitable responses to the needs of student sex workers in Spanish and Italian universities. This pioneering project employs an interdisciplinary, intersectoral, and multi-sited approach to explore student sex work in previously unexamined contexts. COSTI will investigate the interplay between stigmatization, sex work, the education system, and social change and pursues four key objectives: 1) to map the phenomenon of university students in the sex industry in Europe through a comprehensive literature review; 2) to understand the motivations of student sex workers and the social and political factors contributing to their institutional stigma in four of the most important Spanish and Italian universities; 3) to identify the needs of student sew workers together with experts in institutional stigma; 4) to co-create recommendations with student sex workers to prevent discrimination within the academic community. The methodology will combine ethnographic research, quantitative methods, and action research practices. This means realising short online anonymous questionnaires among students and academic staff, face-to-face in-depth interviews and focus groups with student sex workers. COSTI will elevate awareness of student sex work within educational institutions and society, delivering significant benefits to researchers, student sex workers, academic community and civil society at large.

Keywords: sex work,stigma,anthropology of sexuality,higher education,action research,policy recommendations
Roads to Sustainability: exploring the infrastructures of a sustainable future (Roads2SUSTAINABILITY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1367444.0
EU funding (EUR): 1367444.0
Participants: 1
Project status: SIGNED

Roads2SUSTAINABILITY develops a new form of political ecology, infrastructural political ecology. This alters the theoretical work of political ecology (how culture, history and politics make natures), combining contemporary treatments of infrastructure (analyzing how hard infrastructures co-constitute social worlds) with theories of more-than-human assemblage (always changing human/ non‐human relations) and multi-species justice (extending principles of justice beyond humans). These will be led by political ecology’s attentiveness to dynamics of power and scale. Together, this transforms social science debates on infrastructure and political ecology with a new concern for how infrastructure co-constitutes socio-environmental worlds, creating new understanding of how trajectories of co-existence and sustainability are materialized. This is critical given accelerating climate change and global commitments to sustainable development. With a team of 2 post-doctoral researchers and 16 Indigenous researchers, the PI will investigate road building in the Western Amazon and the emancipatory possibilities of alternative infrastructures. Specifically, different types of transport infrastructure (top-down infrastructure, community roads and river networks) at three sites crucial for responses to climate change and sustainability – Indigenous territories, conservation areas and cities. Grounded in collaboration with four Indigenous territories, a core foundation is an innovative but reproduceable decolonial methodology. This is used to address three objectives 1. To investigate how different forms of road and river infrastructure co-constitute trajectories of sustainable development and to conceptualise sustainable development from these material geographies 2. To reveal, analyze and advance the emancipatory possibilities of infrastructure 3. To improve highest ethical standards of how research is undertaken, networked and communicated on Indigenous land.

Keywords: political ecology,sustainable development,infrastructure,decolonial methods,land rights,territorial knowledges,latin america
K-edge imaging for cOLOR Spectral Photon-Counting Computed Tomography in lung diseases IMAGING (KOLOR SPCCT IMAGING)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 1603750.0
EU funding (EUR): 1603750.0
Participants: 1
Project status: SIGNED

Computed tomography (CT) is the mainstay of lung imaging because of its higher spatial resolution, convenience, availability and faster time of acquisition in comparison with other imaging methods such as magnetic resonance imaging (MRI) and nuclear imaging. However, CT’s lack of specificity and absolute quantitative capabilities limits the comprehensive guidance of therapeutic strategies based on imaging assessment of oncologic, inflammatory, and fibrotic pathophysiology processes. Spectral photon-counting CT is an emerging CT technology that not only capitalises on all CT’s advantages but also offers a cutting-edge method of imaging, called Color K-edge imaging. This method allows the specific and quantitative identification of one or multiple atoms concomitantly within a tissue, enabling the simultaneous imaging of independent or interacting pathways. However, K-edge imaging is still limited by its low sensitivity and the scarce availability of contrast agents for potential Human translation, and therefore has not been translated yet to practice. Addressing these issues would be extremely beneficial to the diagnostic and theragnostic evaluation of lung diseases in general and more specifically, lung fibrosis and cancer. Therefore, the goal of this proposal is to develop a framework of SPCCT Color K-edge imaging to provide high-resolution specific and quantitative imaging for non-targeting and targeting agents’ candidates, mainly from the nanobiotechnology field. We will carry out preclinical studies to evaluate the contribution in combination with the contrast agents using different routes of injection, either by intravenous injection or inhalation, on key lung applications: cancer and fibrosis. This will open to the concomitant imaging of lung ventilation and perfusion for monitoring the inflammation and pulmonary agent delivery in animal models.

Keywords: color k edge imaging ventilation perfusion lung imaging spectral photon counting computed tomography lung disease diagnostic