Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Augmented CAD: next generation of computer-aided design & engineering (Xirus)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2018-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Today’s architects, engineers & product designers rely on 3D modelling to design, build & fabricate a wide range of complex products—from household appliances to airplanes. 3D digital models are produced with the help of powerful computer-aided design (CAD) & computer-aided engineering (CAE) software. Most existing CAD/CAE software relies on complex mathematical models that have been developed & introduced ~40 years ago. There have been no major improvements since. Building up on 10+ man-years of our fundamental mathematical research, we have developed a novel augmented CAD solution Xirus. Xirus simulates real-world physical contact between the product designer & the 3D object during the 3D modelling process. With Xirus the designers reshape the digital 3D models as if they were handling them with their hands instead. Xirus provides a 10X+ boost in the efficiency of designers by enabling higher precision & speed of modelling of complex surfaces & volumes. Moreover, Xirus overcomes the mathematical limitations of the existing CAD/CAE software & makes possible high-precision 3D models that current CAD/CAE products cannot support. Xirus is a future-proof technology that will allow smooth transition of 3D designers to usage of novel augmented reality/VR devices. The added value of Xirus has been confirmed by 3 major international architecture firms—Herzog & de Meuron, Foster + Partners & UNStudio. We have published the trial version of Xirus in Jan 2018 to overwhelming interest from the target market (420+ qualified leads in 3 months). Sales will commence in mid 2018. We are aiming at €11m worth of licenses to be sold by 2023 & €32m revenues & 50+ FTEs by 2025. In this Phase 1 project we will carry analysis of key verticals & their market potential, impacts of online marketing, commercial potential of product variants & a go-to-market strategy.

Keywords: 3d design,3d model
Smart Cylinder: Breakthrough hydraulic solution to boost productivity, increase energy efficiency and lower emissions in heavy-duty industrial applications (Smart Cylinder)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy,Slovakia
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-11-01
End date: 2019-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Hydraulic cylinders are essential in heavy-duty industrial machinery (e.g. cranes, excavators…) to withstand the stresses generated by high pressure applications such as construction or earth moving. In recent years, machinery manufacturers have been urgently demanding new technological breakthroughs to improve their machines’ efficiency. This is due to global competition that constrains them to enhance their performance and reduce their prices, coupled with the new environmental restrictions in carbon emissions. This huge business opportunity within the hydraulic cylinders’ market sector – valued at 11.2 bn€ in 2016 and projected at 18.8 bn€ by 2025 –, has been addressed by our consortium, composed of Idraulica Sighinolfi, Italian family-owned company with over 50 years producing high quality cylinders’ manufacture, together with PistonPower, an innovative Slovak technological start-up. Our solution, Smart Cylinder, represents a new generation of hydraulic systems that optimizes operational efficiency. Thanks to our unique internal cartridge amplifier, the pressure is automatically increased when a high force is required. Moreover, high pressure remains inside the cylinder, eliminating the need for high-pressure installations and enabling the reduction of the cylinder geometry. As a result, Smart Cylinder delivers similar push force with reduced cylinder weight and dimensions, offering to Original Equipment Manufacturers higher productivity, an opportunity to save costs and reduced environmental impact. With a Smart Cylinder market size estimated in 100,000 cylinders/year (i.e.750 M€), we expect to boost our companies’ growth after market launch. Starting with our customer base in the Demolition industry, we estimate to capture after 5 years of exploitation, at Idraulica Sighinolfi around 34.7M€ revenues, while PistonPower will reach 7.4M€. Both companies also expect to create +25 new jobs.

Keywords: heavy duty machinery,demolition,construction,power transmission,hydraulic cylinder,high pressure,pressure amplifier,booster,power supply,productivity,energy efficiency,carbon emission
A programme for cosmology from current and next-generation Cosmic Microwave Background experiments (CMBforward)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-04-01
End date: 2026-03-31
Duration (months): 72.0
Total project cost (EUR): 1915814.0
EU funding (EUR): 1915814.0
Participants: 1
Project status: SIGNED

After almost two decades, the Standard Model of cosmology remains deeply unsatisfactory and incomplete from a theoretical viewpoint. Cosmic Microwave Background (CMB) observations provide a unique window into the early universe and are key to answering our most important and unresolved questions. The CMB has been mapped recently with unprecedented precision by the Planck satellite. However, its full potential in testing fundamental physics lies in measurements of its polarization at high resolution and sensitivity. This will be unlocked for the first time with current and future ground-based experiments. The Atacama Cosmology Telescope (ACT) is one of the leading experiments currently operating and from 2021 the new Simons Observatory (SO) will supersede all existing and funded instruments. CMBforward is a programme capitalizing on my expertise built with Planck and ACT, to deliver new CMB cosmology from ACT (during 2020-22) and SO (from 2022) that will advance the state of the art. I will lead work that will take great strides in constraining the properties of neutrinos, the nature of the primordial fluctuations seeding the cosmic structures, the physics of dark matter and dark energy, and the time of cosmic dawn. Recognizing the need and importance of a new dedicated CMB satellite, I will also lead, working closely with other European partners and space agencies, the design of the next CMB mission with European contribution. This proposal presents a workplan for the development of new, more precise, and robust data analysis techniques, and requests support for the research time and resources needed for analysis and scientific exploitation of the high volume of incoming data. Building on my expertise in characterizing and interpreting CMB data, and with leadership established and secured in key current and future experiments, this project is unique in bringing together past, present and future CMB studies, and will be at the forefront of key frontiers in cosmology.

Keywords: neutrino physics,inflationary cosmologies
In vivo Imaging Genesis and Circuit Integration of Interneurons Engineered from Glia (IMAGINE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2143826.0
EU funding (EUR): 2143826.0
Participants: 1
Project status: SIGNED

Direct lineage reprogramming of cell identity in the nervous system offers the prospect of remodelling diseased brain circuits. Recent years have provided evidence for the possibility of converting brain glia into neurons in vivo. Yet, the process by which glial cells give up their original identity and adopt a neuronal fate remains by large enigmatic. Moreover, it is unclear how neurons induced from glia may integrate into the pre-existing circuits of non-neurogenic brain regions such as the cerebral cortex. Finally, can they participate in cortical information processing and even restore dysfunctional cortical circuits? We have discovered a specific cocktail of reprogramming factors that gives rise to induced neurons with hallmark features of fast-spiking, parvalbumin-expressing interneurons, a neuronal subtype that is highly vulnerable in neuropsychiatric and neurological disorders. Here, we aim at visualising the conversion of glia into these induced interneurons in real time by in vivo imaging. This will not only unambiguously demonstrate the genuineness of the identity switch, but also unveil cellular intermediates along the reprogramming process. By measuring single cell gene expression during conversion, we will be able to relate intermediate states to their molecular underpinnings. Moreover, in vivo imaging will allow us to follow structural remodelling of dendrites as induced interneurons integrate into pre-existing cortical circuitry. By using in vivo calcium imaging in primary visual cortex, we will examine whether induced interneurons become recruited into sensory information processing circuits. Finally, we will scrutinise induced interneurons for their ability to rescue excitation-to-inhibition balance in a mouse model of endogenous interneuron dysfunction. IMAGINE will thus break new ground towards unveiling the full potential of engineered neurogenesis for brain repair.

Keywords: cell fate,lineage reprogramming,proneural,transcription factor,dendritic remodelling,in vivo calcium imaging
A holistic design of secure vehicular networks: communications, data caching and blockchain services (SEEDS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Singapore,China,United Kingdom,Portugal,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 565800.0
EU funding (EUR): 340400.0
Participants: 6
Project status: SIGNED

With the rapid development of future connected vehicles, Cyber Security has been gaining increasing importance to the connected systems that are fundamental to our society, health and welfare. It will be given priority to the upcoming areas, including autonomous systems and cyber-physical systems, etc. The SEEDS project sets an ambitious research agenda to fully exploit the potentials of V2X communications, data caching and blockchain services for revolutionizing the security and privacy of vehicular networks. Particularly the overall aim of SEEDS is to accelerate the transfer and deployment of research knowledge between European countries and third-country (TC) partners in order to realize a cross-layer design of reliable and robust security for V2X networks, and meet the challenging security requirements, that is confidentiality, integrity, privacy-preserving, trust and scalability. The technical approach is seeking is two-fold. One is to pursue a new design of spectrum efficient and decentralized approaches to address security challenges in physical layer communications and upper layer content disseminations by fully exploring the practical and theoretical analysis, dynamic nature of channels/traffic patterns and self-learning techniques, which provides the theoretic aspect of the project. Then, the second step is from the practical aspect, where the proposed security methods and their performance will be validated using large scale simulations and testbed provided by the TC partners. The proposed vehicular mechanisms are expected to facilitate an increasing number of vehicular applications with flexible availability, high confidentiality and robust integrity.

Keywords: vehicular communications and networks,cyber security,data centric networks,blockchain
Highly-lubricated soft contact lenses (ContactLube)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-01-01
End date: 2016-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The object of this proof of concept project is to modify soft contact lenses to render them more lubricated, and so make them far more comfortable to use. We propose to improve greatly the lubricity of soft contact lenses, used by over 100 million people worldwide with a market of around $7.5bn, and for which acute discomfort may arise from high friction at the interfaces between the lenses and the eyelid or cornea. According to an established clinical hypothesis, ocular comfort is related to the level of friction between the anterior side of the contact lens and the inner eyelid occurring during the blinking process, and boundary lubrication is the key to providing user comfort during extensive wearing of soft contact lenses. High lens friction, for a substantial part of the user population, can limit the extent to which soft lenses may be used and can also aggravate pathologies such as dry eye syndrome. Thus soft contact lenses that are much better lubricated than those currently in use have clear economic and health-related benefits. The current project, working through 5 work-packages, will establish the feasibility, will carry out competitive analysis, explore the commercialization process and the IPR position, and seek contacts with appropriate industrial partners to further develop the commercialization of this idea.

Keywords: soft contact lenses,hydration lubrication,lubricated contact lenses,contact lens comfort,dry eye syndrome
Excellent research and expertise of quality of cancer care by internationally trained staff (INEXCA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Belgium,Finland,United States,Denmark,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-03-01
End date: 2019-02-28
Duration (months): 48.0
Total project cost (EUR): 913500.0
EU funding (EUR): 913500.0
Participants: 8
Project status: CLOSED

There is an international imperative to improve healthcare through health service research, including nursing research and new innovations. This EU-RISE project “Excellent research and expertise of quality of cancer care by internationally trained staff (INEXCA)” aims to utilize expertise across the globe to improve research, researcher training and care of cancer patients, family caregivers and patient and public involvement through international and intersectoral collaboration and staff exchange. The ultimate objectives are to create innovative opportunities to improve research and researchers’ skills and increase knowledge transfer from research to practice and business. The participants in the project representing academic, non-academic and clinical settings as well as information technology industry and health-related business experts from Belgium, Denmark, Finland, Italy, Great Britain and United States of America have enormous and interdisciplinary competences of their specializing areas in research methodology, quality of care, cancer care, patient involvement, family care givers and information technology in academic, non-academic and clinical settings. The participating organizations will bring their best know-how through staff’s secondments, workshops, training courses, conferences, publications and other activities. An innovative ICT platform will be developed for sharing information and knowledge. In total, 34 academic and non-academic staff members will be involved in this INEXCA project for 263 months. The participants’ synergies and complementarities from different disciplines, experiences, methodological advancements as well as clinical practice will be fully in use. The planned secondments will offer the best opportunity to get the best outcomes for patients, families, EU citizens as well as researchers. Descriptors: HEALTH SERVICES, HEALTH CARE RESEARCH

Keywords: quality of care,cancer,patients,methodology,training,staff exchange
Parallel Numerical Linear Algebra for Future Extreme-Scale Systems (NLAFET)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: High Performance Computing
Action type: Research and Innovation actions
Countries involved: Sweden,France,United Kingdom,United Kingdom
Call: HPC Core Technologies, Programming Environments and Algorithms for Extreme Parallelism and Extreme Data Applications (H2020-FETHPC-2014, 2014)
Start date: 2015-11-01
End date: 2019-04-30
Duration (months): 42.0
Total project cost (EUR): 3907375.0
EU funding (EUR): 3907375.0
Participants: 5
Project status: CLOSED

The NLAFET proposal is a direct response to the demands for new mathematical and algorithmic approaches for applications on extreme scale systems, as identified in the FETHPC work programme and call. This project will enable a radical improvement in the performance and scalability of a wide range of real-world applications relying on linear algebra software, by developing novel architecture-aware algorithms and software libraries, and the supporting runtime capabilities to achieve scalable performance and resilience on heterogeneous architectures. The focus is on a critical set of fundamental linear algebra operations including direct and iterative solvers for dense and sparse linear systems of equations and eigenvalue problems. Achieving this requires a co-design effort due to the characteristics and overwhelming complexity and immense scale of such systems. Recognized experts in algorithm design and theory, parallelism, and auto-tuning will work together to explore and negotiate the necessary tradeoffs. The main research objectives are: (i) development of novel algorithms that expose as much parallelism as possible, exploit heterogeneity, avoid communication bottlenecks, respond to escalating fault rates, and help meet emerging power constraints; (ii) exploration of advanced scheduling strategies and runtime systems focusing on the extreme scale and strong scalability in multi/many-core and hybrid environments; (iii) design and evaluation of novel strategies and software support for both offline and online auto-tuning. The validation and dissemination of results will be done by integrating new software solutions into challenging scientific applications in materials science, power systems, study of energy solutions, and data analysis in astrophysics. The deliverables also include a sustainable set of methods and tools for cross-cutting issues such as scheduling, auto-tuning, and algorithm-based fault tolerance packaged into open-source library modules.

Keywords: numerical linear algebra,software libraries,portability,robustness,multi core,heterogeneous arc hitectures,communication avoidance,auto tuning,scheduling,fault tolerance,extreme parallelism
Metal-Mediated Methods for the Functionalization of White Phosphorus (P4) (FunctionalP4)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-09-01
End date: 2023-08-31
Duration (months): 60.0
Total project cost (EUR): 1955846.25
EU funding (EUR): 1955846.25
Participants: 1
Project status: SIGNED

Organophosphorus compounds are an important and industrially relevant class of molecules with numerous uses, e.g. as reagents in organic synthesis, ligands in catalytically active metal complexes, and in pest control. State-of-the-art synthesis methods for all these valuable and useful compounds rely on an atom inefficient and hazardous multi-step procedure involving the oxidation of white phosphorus (P4) with toxic chlorine gas. Less wasteful and more environmentally benign methods are highly desirable, but transformations of white phosphorus directly into organophosphorus compounds are hardly developed. This project explores new methods for the activation and functionalization of white phosphorus. The metal-mediated stepwise transformation of P4 into organophosphorus compounds is a key objective. Novel transition metal compounds are designed and synthesized, which can generate reactive phosphorus units. The concept of heterobimetallic P4 activation, where two electronically different metal complexes interact with P4 cooperatively, is introduced for this purpose. Reactions of the phosphorus fragments in these new, reactive complexes with electrophiles will produce novel, fundamentally interesting organophosphorus compounds avoiding chlorinated intermediates. Catalytic methods for P4 functionalization are currently unknown, and developing such methods using transition metal and photoredox catalysts is an additional objective of this proposal. By providing novel synthetically useful and even catalytic procedures for converting P4 into organophosphorus compounds, this project will significantly contribute to the development of phosphorus chemistry and more sustainable synthesis methods.

Keywords: phosphorus,transition metal compounds,inorganic chemistry,organometallic chemistry