Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Genomics of Luminescence in Mycena Mushrooms (GLiMMer)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: CLOSED

Sailors called it “burning of the sea”, Shakespeare described it as “pale fire” and Aristotle named it “cold light”. The glimmer they witnessed was light emitted by living organisms or bioluminescence. While it represents one of the most striking examples of convergent evolution across the tree of life, in Fungi it has a single origin in the Agaricales order, Basidiomycota. In particular, Mycena, a large genus of mushroom-forming fungi, includes most of known bioluminescent species together with hundreds of species that lost the ability to emit light. In GLiMMer, I will study the evolution of fungal bioluminescence and test the hypothesis that multiple, lineage-specific mechanisms led to the convergent loss of this trait, providing clues for its ecological relevance. To date, Mycena lacks a robust phylogenetic framework and is heavily under sampled. Fungarium collections, such as the one at Naturalis, preserved thousands of Mycena specimens over the past centuries. Thanks to new high-throughput sequencing methods these collections are being transformed in genomics resources, bridging taxonomy and evolution. In GLiMMer, my expertise in fungal genomics will serve to develop a genome-based classification of Mycena, that combines contemporary and museum specimens. I will generate assemblies of 100 representative species using short-read sequencing. Next, I will extract phylogenetically informative loci to design a target sequence capture method for recalcitrant museum specimens for the first time in mushrooms. Then, I will use the new classification to select reference species and obtain chromosomal-level assemblies using long-read sequencing. Finally, with genome-wide synteny analyses I will investigate the evolutionary circumstances that led to the birth and death of bioluminescence in Fungi. By integrating taxonomy, genomics and evolution, my project will create a paradigm shift in our knowledge on fungal biodiversity and ultimately contribute to its conservation.

Keywords: fungal genomics,museomics,long read sequencing,next generation sequencing,target enrichment via dna hybridization capture
Upcycling PHAs to innovative materials for fully sustainable food packaging (SATISPHACTION)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Spain,Portugal,United Kingdom,France,Belgium
Call: Nature inspired alternatives for food packaging and films for agriculture (HORIZON-EIC-2024-PATHFINDERCHALLENGES-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 4378020.65
EU funding (EUR): 3735886.83
Participants: 9
Project status: SIGNED

Conventional fossil-carbon plastics represent a significant environmental challenge due to their large carbon footprint and poor biodegradability in natural environments. A substantial portion of plastic production is dedicated to food packaging, contributing heavily to global plastic pollution. PHA (polyhydroxyalkanoate), a biopolymer naturally produced by bacteria, presents a promising alternative as it is fully biodegradable, renewable, and has a low carbon footprint. However, despite its environmental benefits, PHA currently faces significant barriers to widespread adoption: it is expensive, compostable but not recyclable, and hard to process and therefore has to be blended with other less environmentally friendly polymers to form plastics. The SATISPHACTION project will address these issues by developing innovative recycling processes for PHA, with computational assistance. Moreover, the consortium will develop new formulations with increased PHA content, no harmful additives, and thermostable enzymes for accelerated self-degradation. We will demonstrate the viability of these advances through three specific food packaging use cases. We will demonstrate the complete biodegradation of these plastics in natural soils, and fresh and marine water environments, and determine their complete lifecycle impacts.

Keywords: biopolymers,recycling,upcycling,chemistry,computational aided chemistry,machine learning,bio engineering
Exciting Iron Catalysis: A route towards sustainable cross-couplings Enabled by Light (ExCEL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499995.0
EU funding (EUR): 1499995.0
Participants: 1
Project status: SIGNED

The manufacture of many high-value chemicals that sustain our daily lives depends on the ability of palladium catalysts to link together (cross-coupling) complex structural motifs. Yet, in view of the rapid increase of the price of palladium and its progressive depletion, it is crucial to invent alternative and more sustainable systems based on Earth-abundant metals to ensure the viability in the long term of these strategic processes that provide us with materials, agrochemicals or medicines. Iron is considered the most benign of transition metals because it is endless, inexpensive and biocompatible. However, despite its early discovery, iron-catalyzed cross-couplings have been underutilized owing to their narrower scope and the need for strong organometallic reductants or harsh conditions, which hampers their applicability in complex targets and densely-functionalized substrates. This proposal introduces a fundamentally new approach to overcome the issues that restrain the development of iron-catalyzed cross-couplings, exploiting the innate ability of iron complexes to harvest light and repurposing it to “activate” catalysis. Capitalizing on novel modes of reactivity accessed upon visible-light irradiation, this research programme offers a strategy to access key catalytically active iron species under mild conditions without the use of strong organometallic reductants, enabling unprecedented transformations with extended scope. ExCEL recruits charge-transfer excited states of iron complexes, providing access to Fe(I)/Fe(III) and Fe(0)/Fe(II) catalytic manifolds to achieve C–C and C–heteroatom bond formation as well as multicomponent reactions that are currently out of the reach of state-of-art iron catalysis. Overall, this proposal aims to introduce a new paradigm to upgrade and unleash the full potential of iron catalysis in organic synthesis, and will pave the way for the discovery of exciting new synthetic transformations.

Keywords: photocatalysis,iron catalysis,cross coupling,excited states,photochemistry,sustainability
Deciphering information encoded on the nanoscale (NanoArchive)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 1499916.0
EU funding (EUR): 1499916.0
Participants: 1
Project status: SIGNED

Despite the natural ubiquity of nano- and microparticles and their increasing production and emission in anthropogenic processes, we struggle to understand their direct impact on environment and health. This is anchored in their elusive nature and analytical challenges arising from it. Although current approaches can retrieve some facets, we are blind for a majority of properties or cannot retrieve them coherently. We are in a dire need to decipher basic traits of particles and gain more comprehensive insights in their compositions, size distributions and abundances. Only this way, we can advance on our understanding on origin, implication, and fate of particulate entities. “NanoArchive” will provide new paradigms and innovations to enable the analysis of particles and aims to close a persistent gap in our understanding of the world at the nano- and microscale. The technological innovation is based on the convolution of elemental mass spectrometry, optical traps, and molecular spectroscopy to promote characterisations on a single particle level. The hyphenation of newly emerging technologies goes far beyond the current state-of-the-art but provides new opportunities to gain complementary and comprehensive perspectives on particles. Our aim is the empowerment of non-target particle analyses, the identification of integral molecular and elemental information and the bottom-up modelling of dispersion parameters using single particle data. This way, we will be able to bring particle science to a ground-breaking new level, allowing us to understand particles in our environment. The application potential of “NanoArchive” will be demonstrated by focussing on glacier ice cores – the ideal archive to investigate natural background as well as the chronological evolution of human emission. However, the full impact of “NanoArchive” goes much beyond, potentially revolutionizing the analytics and understanding of particles in fields like geology, biology, or medicine.

Keywords: single particle analysis,elemental mass spectrometry
Translating the Image: Art, Science and Global Imagination in the first Islamic Description of the New World (Tarih-i Hind-i Garbī / History of the West Indies), 16th-20th Centuries (America-Islamica)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 209483.28
EU funding (EUR): 209483.28
Participants: 1
Project status: SIGNED

America-Islamica investigates a little-known and unstudied corpus of illustrated and painted books known as The Tarih-i Hind-i Garbi (History of the West Indies) or the New Hadith, and in Persian translation as the Tarjuma-yi tā’rikh-i yangī dunyā (Translation of the History of the New World). The first non-indigenous and non-European history of the Americas, this account of the Spanish conquest and colonization was composed in Ottoman Turkish in Istanbul based on Italian translations of Spanish sources in the 1580s. Manifesting rich layers of multidirectional translation, the work’s journeys, crossings, and circulations in text and image, geographically and temporally—from Spanish and Italian to Ottoman Turkish, Persian and French, from the Americas to Spain, Italy and the Ottoman capital to Iran and India, and more recently to Europe and the U.S., and from manuscript to printed editions in form that span three centuries—speak to the esteem, admiration, wonder, and appeal it exuded. Inherently interdisciplinary, this study will introduce the work to a wider contemporary audience. An in-depth analysis of its text and image in various formats, languages and canons, will enrich our understanding of early modern travel and colonization from the perspective of the non-colonizers, who were acutely curious and interested in knowing about the confines of the earth, and in competing for its domination.

Keywords: islamic art history,early modern history,global history,ottoman,ottoman turkish,persian,visual translation,manuscript and print arts and cultures
Co-creating strong uptake of REMEDIES for the future of our oceans through deploying plastic litter valorisation and prevention pathways (REMEDIES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Slovenia,Greece,Germany,Italy,Croatia,Spain,Belgium,France,Albania,Ireland,Morocco,Serbia
Call: Mediterranean sea basin lighthouse - actions to prevent, minimise and remediate litter and plastic pollution (HORIZON-MISS-2021-OCEAN-03, 2021)
Start date: 2022-12-15
End date: 2026-12-14
Duration (months): 48.0
Total project cost (EUR): 9137345.35
EU funding (EUR): 7999644.75
Participants: 23
Project status: SIGNED

The project is built around the three main pillars of monitoring plastic litter, its collection and valorisation and, of course, the prevention of the distribution of non-degradable plastics. We will do so by strongly building on former projects addressing these topics and by connecting to previously identified major initiatives active in this area. For us, the most promising aspect is the activation and necessary participation of citizens affected by plastic pollution directly on the shorelines. We will guide them to becoming plastic entrepreneurs with a deeply rooted knowledge base and the right tools to start their own businesses through the valorisation of collected plastic litter and the provision of zero-waste solutions to all actors. We plan to employ 4 breakthrough innovations per pillar (monitoring, collection, prevention) that are neatly interwoven, building upon each other to create an even better whole. We will test these solutions in 8 demonstration sites in 8 Mediterranean countries and after validation, scale them up in 33 more sites with the potential to be launched across the whole Mediterranean. In parallel we will run two open calls to third parties to attract more solutions for implementation following our same methodology. All-in-all, we plan to map out 170 km2 for plastic litter, reach circa 100,000 citizens, collect around 400 tons of plastic waste, and build up plastic prevention pathways through scaling and replication for an equivalent of 3,700 tons of plastic.
Democratising the Family? Gender Equality, Parental Rights, and Child Welfare in Contemporary Global History (DEMFAM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 1999546.0
EU funding (EUR): 1999546.0
Participants: 1
Project status: SIGNED

Through the lens of ‘shared and equal parenting’, DEMFAM studies the transformation of gender and the family in contemporary global history. First, it studies a shift from hierarchical to egalitarian conceptions of family relations, or a democratisation of the family. This entails the equalisation of parental rights within and outside the domain of heterosexual marriages, which coincided with the harmonisation of the rights of marital and non-marital children. The emergence of post-familial care arrangements, secondly, led to a denser regulation, or juridification of co-parenting. Inner-familial power shifts were accompanied by a reconfiguration of family-state relations. The project investigates the development of judicial and extra-judicial institutions (including family courts, social work interventions, and mediation agencies) which aimed to promote parental cooperation and safeguard child welfare in familial conflict situations. Finally, it shows how parental rights assumed centre stage in the twenty-first century’s ‘gender wars’, or the politicisation of gender, sexuality, and the family in struggles over national and religious identity, liberalism, and democracy. DEMFAM analyses these (limited and contradictory) transformative processes across different political-economic and legal systems within a shared global environment. The project develops a social history of law reform on different political scales to understand global dynamics of divergence and convergence in the transformation of gender and the family. It combines the analysis of transnational knowledge circulation (including policy transfer, civil society mobilisation, and scientific expertise) with the comparative study of family change in Western Europe (FRG, UK), Central Eastern Europe (the GDR, Poland), and South Asia (India). Integrating research on post-colonial legal pluralism, and on (post-)socialist gender and family politics, DEMFAM opens new horizons for global gender history.

Keywords: global gender history history of the family gender equality care childcare child custody parental rights
LILY: A Breakthrough Technology to Prevent Chemotherapy-Induced Hair Loss (LILY)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-10-01
End date: 2026-03-31
Duration (months): 30.0
Total project cost (EUR): 4107666.25
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Chemotherapy-induced alopecia (CIA) is hair loss associated with chemotherapy treatment for cancer. LILY is a portable, comfortable, and effective CIA prevention device that uses localised microvasculature compression therapy (LMCT) to prevent CIA. The LILY device uses this unique LMCT technique to reduce perfusion at the scalp and prevent the destructive action of chemotherapy on hair follicles. By applying a consistent low-level pressure (between 35 and 60 mmHg) to the local micro blood vessels, which could deliver chemotherapy drugs to fast-dividing hair follicles, the vessels are temporarily compressed, inhibiting drug delivery. The device comprises a proprietary pneumatic bladder network design and soft robotics system with the ability to non-invasively induce vasoconstriction in superficial vessels of the scalp to mechanically control tissue perfusion, and an electronic control system for both patient management of the system and real-time feedback into the treatment protocol.

Keywords: automation and control systems,micro system engineering,business model innovation,chemotherapy induced alopecia,chemotherapy,breast cancer
Young Children of Disadvantaged Families: A Comprehensive Analysis of Parental Human Capital Investment and Child Health (YouCDF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: United States,Türkiye
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 171521.28
EU funding (EUR): 171521.28
Participants: 2
Project status: SIGNED

Promoting new-born and children’s health is a policy priority for sustainable development and the EU takes action to “promote inclusive and child-friendly societies, health and education systems” (Thematic area 2 of the EU Strategy on the Rights of the Child). Nevertheless, within country differences exist in children’s access to essential health care especially among the vulnerable groups of undocumented migrants and children living in poverty. An obvious obstacle for access to health care for the irregular migrants is lack of universal health coverage. Another significant determinant of restricted health care utilization of these vulnerable children is the challenges associated to the socioeconomic status of the parents. There is little research to show methods to eliminate the health risks associated to displaced children and children living in poverty and to integrate them into the European health system. The overall goal of YouCDF is to provide a systematic and comprehensive analysis of the amount, types and short- and long-term consequences of parental investment to children from the perspective of health economics. YouCDF will: -investigate the extent to which the limitations in the household level (restricted financial resources available to the main caregivers) could be compensated by a universal health care system, -test the empirical implications of the model, - inform policy makers about the potential risks to the public health system caused by underinvestment to children, and related inequalities. YouCDF addresses one of the potential public health challenges for Turkey and the EU: The number of children who have limited access to nutritious food increases as a result of hosting refugee children from Syria and facing increased food prices due to the war in Ukraine.

Keywords: health economics,health care use,child health,inequality in health,public health,vulnerable children,maternal bargaining power,universal health care,burden of disease