Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Breeding for Resilient, Efficient and Sustainable Organic Vegetable production (BRESOV)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Spain,Italy,Germany,Italy,Italy,Belgium,Tunisia,Korea, Republic of,Switzerland,Romania,China,Switzerland,France,France,France,Czechia,United Kingdom,Portugal
Call: Organic breeding – Increasing the competitiveness of the organic breeding and farming sectors (H2020-SFS-2017-2, 2017)
Start date: 2018-05-01
End date: 2023-04-30
Duration (months): 60.0
Total project cost (EUR): 6989348.5
EU funding (EUR): 5962019.75
Participants: 23
Project status: SIGNED

The project deals with the urgent need to provide climate-resilient cultivars addressed to organic vegetable production systems. These new cultivars will benefit organic growers, and the organic seed industry, providing much needed security both under current and future scenarios of climate change. In this project, we will exploit the genetic variation of broccoli, kohlrabi, bean and tomato for enhanced productivity, by exploiting up-to-date knowledge of genome structure and function. This work will be enhanced by the active involvement of farmers, advisory services, research institutes, breeding companies and food processors from diverse geographical/climatic contexts in Europe and Non-EU countries. The selection of pre-breeding/ breeding lines for the three species will be undertaken in organic vegetable farming systems, utilizing an annual crop rotation scheme. New cultivars will be selected for efficiency when grown under water, temperature, and nitrogen stress, for resistance to some pests and diseases, for desirable product quality traits such as taste, visual appearance, post-harvest performance. The Stakeholder Board will contribute to the expected outcomes of the project. Crop genetic diversity will be broad as we will be utilizing several landraces (LRs) and crops wild relatives (CWRs) provided by partners for the foreseen pre-breeding and breeding activities. We will adopt an innovative approach, where plant traits related to the roots-zone, and to root-growth, and architecture that enable a better interaction with organic soil and its microbiome, are sought to benefit the end-users. This approach will ensure that the available genetic resources and bred-germplasm, combined with the best on-farm management practices will enhance resource use efficiency and productivity. The germplasm from this project will act to pump-prime the production of new seed for the organic growing sector and will also serve as a model for the enhancement of other crops.
Higher-order constitutive relations for granular materials: a multi-scale approach (ICARUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

The mechanical behaviour of granular materials subjected to large deformations is important in many problems in science and engineering. Current numerical simulation methods using zeroth-order constitutive relations give results that are dependent on the employed mesh size. This problem can be circumvented by using higher-order constitutive relations. However, current higher-order constitutive relations are heuristic, thus in many cases the results are still mesh-size dependent. Using an innovative multi-scale approach, I will constructively challenge current higher-order continuum theories from a fundamental perspective, namely by consideration of the underlying microstructure, in order to obtain mesh-independent solutions. In ICARUS, I will: 1) develop micromechanical expressions for three-dimensional higher-order strain and stress tensors for granular materials, 2) construct higher-order constitutive models within the thermodynamic framework, based on micromechanical analyses of DEM simulations, and 3) demonstrate their capabilities in solving “benchmark” geotechnical large-deformation problems. My investigation results in a computational simulation method that provides valuable insights in large-deformation engineering problems and thus will aid in assessing and reducing risks of natural hazards, with benefits for society. Under the guidance of Prof Kruyt, an internationally-recognised expert on micromechanics of granular materials, and of my high-level international steering committee, I will acquire deep knowledge on granular micromechanics and higher-order continuum theories. This lays a solid foundation for my scientific career. ICARUS paves the way for my ambition to become an outstanding independent researcher on multi-scale studies of granular materials, by significantly strengthening my scientific skills and track record, enhancing my mentoring and teaching capabilities and expanding my international scientific network.

Keywords: granular materials,micromechanics,higher order continuum,fabric tensor,constitutive relations,microstructure,dem simulations,large deformation problems
Grating Reflectors Enabled laser Applications and Training (GREAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Germany,Germany,Germany,Finland,France,France,France,France,France,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-03-01
End date: 2024-01-31
Duration (months): 59.0
Total project cost (EUR): 4058697.24
EU funding (EUR): 4058697.24
Participants: 15
Project status: SIGNED

The overall aim of the GREAT (Grating Reflectors Enabled laser Applications and Training) project is to train a cohort of 15 ESRs through the completion of interconnected individual projects which will deliver innovative approaches for development and use of Grating Waveguide Structures (GWS), from design to implementation in several laser systems. GWS results from the combination of sub-wavelength gratings and planar waveguides. This combination results, by means of an appropriate design of the overall GWS, in resonances which can be used for many applications that are more efficient than current grating-only devices. The young will be trained to work collaboratively to deliver systems and solutions responding to realworld problems. This is crucial since there is an overall lack of qualified specialized personnel in this field, with a limited number of companies active worldwide. Crucially, this lack of skilled workforce has been identified by the ETP Photonics21 (Photonics21 (2013) Towards 2020 – Photonics driving economic growth in Europe-Multiannual Strategic Roadmap 2014 – 2020) as a major challenge for the photonics community. Moreover, GREAT gathers Photonics, Micro-Nano technologies, Advanced materials as well as Nanotechnologies which are among the Key technologies defined within the H2020 project for the competitiveness and renewal of European manufacturing. Lasers are also defined as an important industrial sector, where the European Community is a key player which aims to keep its competitive position (http://www.strategies-u.com/ lasers-photonics.html). Therefore, GREAT will provide important modelling methods and fabrication tools that allow the development of GWS to consolidate and expand their use in several applications in the laser field like pulse compression, spectral stabilization and wavelength multiplexing, as well as polarization shaping (generation of beams with radial and azimuthal polarization

Keywords: grating waveguide structures,coatings,pulsed laser deposition,lithography,etching,polarization shaping,spectral stabilization and multiplexing,pulse compression,ultrafast,lasers,diode lasers
ENergy TRANsitions from Coal and carbon: Effects on Societies (ENTRANCES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Robust decision making and public engagement
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Italy,Spain,Belgium,Norway,Romania,Poland,Slovakia,France,United Kingdom,Portugal
Call: Social Sciences and Humanities (SSH) aspects of the Clean-Energy Transition (H2020-LC-SC3-2019-NZE-RES-CC, 2019)
Start date: 2020-05-01
End date: 2023-10-31
Duration (months): 42.0
Total project cost (EUR): 2999523.75
EU funding (EUR): 2999523.13
Participants: 14
Project status: SIGNED

This project is framed under the topic "SSH aspects of the Clean-Energy Transition" and it tries to interpret the "Challengues facing the carbon intensive regions" within a multi-contextual framework: 1) the de-carbonisation policies; 2) the ongoing processes of de-territorialisation; and 3) the territorial dimension of clean energy transition. These contextual elements are presented in the project, providing an interpretation of the main research questions of the topic.: a) The de-carbonisation of coal and carbon intensive regions risks to be a cul de sac of the energy transition process. Along with this process a set of conflicts emerge and move from local to national and European level and vice-versa. One of the main ideas of the project is analysing these conflicts and the negotiation processes related to them, as well as the political cultures and discourses behind these conflicts; b) The challenges facing coal and carbon-intensive regions are studied in the light of the ongoing process at the territorial level. Another main idea of the project is to identifying the factors of de-territorialisation in action in different coal and carbon-intensive regions and to explain their dynamics and interactions; c) The clean energy transition cannot be understood only as a technological change or as an industrial shift, and it is studied as a socio-economic-psychological process affectng the life of local communities. In this respect the project is focused on the study of the coping strategies from a wide array of perspectives: A multidimensional perspective, combining different disciplinary frameworks; a comparative perspective, developing a comprehensive set of case studies; and a multilevel perspective, involving different key players at territorial, regional, national, European and global level. Each of these strategies will be developed in a specific strand of research: Theoretical strand, Analytic strand, and Pro-active strand.

Keywords: clean energy transition,de carbonisation policies,de territorialisation,multilevel analysis
Microphotonics-based frequency combs for habitable exoplanet detection (STARCHIP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-05-01
End date: 2025-04-30
Duration (months): 60.0
Total project cost (EUR): 1950000.0
EU funding (EUR): 1950000.0
Participants: 1
Project status: SIGNED

Without doubt, one of the most intriguing questions in modern astronomy is whether habitable planets, potentially supporting life, exist outside our solar system. In the upcoming era of large aperture astronomical telescopes and highly stable spectrometers, answering these questions is for the first time a tangible possibility. Successfully finding answers to these questions will, however, critically rely on non-incremental advances in astronomical instrumentation. The objective of the proposed research is, developing and demonstrating novel photonic-chip laser frequency combs to support the revolutionary advances in astronomical precision spectroscopy required to enable detection and characterization of habitable Earth-like planets. Habitable exo-planets can be discovered by observing minute wavelength-shifts in the optical spectra of their host stars. These wavelength-shifts are so small that exquisitely accurate and precise wavelength-calibration of astronomical spectrometers is required. It has been recognized that laser frequency combs (LFCs), broadband spectra of laser-lines with absolutely-known optical frequencies, can provide the required level of precision, provided the LFCâ€™s lines can be resolved by the spectrometer. Generating such frequency comb spectra (â€œastrocombsâ€?) with resolvable lines remains, however, exceedingly challenging. Here, we will develop and demonstrate a novel class of photonic-chip microresonator-based astrocombs that can naturally provide broadband spectra of resolvable lines, potentially from visible to mid-infrared wavelengths, thereby overcoming key challenges in astrocomb generation. In order to achieve this goal we will pursue radically different microresonator designs and new nonlinear optical regimes in order to overcome long-standing limitation in microresonator physics. The developed astrocombs will not only be pivotal to astronomy but indeed can directly and profoundly impact the way we transfer data, monitor our environm

Keywords: microresonator frequency combs,microphotonics,nonlinear optics,frequency combs,astronomical spectrograph calibration
Semi-autonomous border surveillance platform combining next generation unmanned aerial vehicles with ultra-high-resolution multi-sensor surveillance payload (BorderUAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Strengthen security through border management
Action type: Research and Innovation actions
Countries involved: Ukraine,Italy,Spain,Malta,Cyprus,Belarus,Greece,Moldova, Republic of,Bulgaria,Greece,Romania,Serbia,Greece,Croatia,Romania
Call: Technologies to enhance border and external security (H2020-SU-SEC-2019, 2019)
Start date: 2020-06-01
End date: 2023-11-30
Duration (months): 42.0
Total project cost (EUR): 6997332.5
EU funding (EUR): 6997332.5
Participants: 19
Project status: SIGNED

The project will combine for the first time a multi-role lighter-than-air (LTA) unmanned aerial vehicle (UAV) with an ultra-high resolution multi-sensor surveillance payload supporting border surveillance as well as search & rescue applications, and specifically rough terrain detection. The sensor payload will include synthetic aperture radar (SAR), laser detection and ranging (LADAR), shortwave/longwave infrared (SWIR/LWIR) and acoustic cameras for direct target detection, as well as optical and hyperspectral cameras for indirect detection (via vegetation disturbance). The project will use the ground-based infrastructure of border police units (command & control centres), innovative data models (to identify illegal crossing patterns and preferred routes) and advanced audio/video analytics and storage (to provide additional detection capabilities). The technology concepts will be validated in the field by 6 border police units (Greece, Bulgaria, Romania, Moldova, Ukraine, Belarus) covering 3 major illegal migration routes into Europe (Eastern Mediterranean, Western Balkan and Eastern Borders Routes), which represent 58% of all illegal border crossings detected and are also the most used for smuggling of drugs, weapons and stolen vehicles. The combined solution will provide high coverage, resolution and revisit time with a lower cost (4 EUR/kg/hr) than satellites and higher endurance (100 kg payload for 12 hours) than drones. Based on the field trial results, the consortium expects to develop a solution that can be deployed further by European border polices after project completion. The project will also involve the contribution of NGOs working with illegal migration and human right protection issues, as well as regulatory experts dealing with the ethics and privacy requirements of border surveillance solutions

Keywords: ladar,radar,swir,lwir,acoustic camera,data processing,data fusion
Cerebral organoids: human mini brains in a dish open up new possibilities for drug development in neurodegenerative and developmental diseases (Mini Brains)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2017-01-01
End date: 2018-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Transferring results from animal models to humans is a major bottleneck in pharmaceutical research. This is particularly true for brain disorders, including neurodegenerative and developmental diseases. Both animal models and conventional cell culture methods fail to recapitulate the complexity of the human brain and there are fundamental differences in developmental and physiological aspects between humans and the commonly used animal models. The high attrition rate of drugs for brain disorders has led major pharmaceutical companies to severely downsize their respective departments. To overcome the inherent limitations of current in vitro and in vivo models for brain disorders, we have generated a proprietary human pluripotent stem cell-derived 3D organoid culture system, termed cerebral organoids. These cerebral organoids are ‘mini brains’ that grow in a petri dish , display discrete but interconnected brain regions and recapitulate features of human brain development. ‘Mini Brains’ can be derived from patient-specific stem cells and represent a unique opportunity for creating specific human disease models in a 3D culture. The aim of the ‘Mini Brain’ project is to investigate the commercial feasibility of cerebral organoids as a new and highly cost-effective tool in the discovery and development of therapies for neurodegenerative and developmental diseases. The use of patient-specific cerebral organoids for drug screening and validation offers an alternative to animal experiments, reducing costs and animal use and improving reliability of results, and has the potential to decrease the cost of drug development, reduce the brain disease burden and increase the rate of approved drugs for brain disorders.

Keywords: cerebral organoids,3d culture,neurodegenerative disease,developmental disease,reduction of animal experiments
Molecular Evolution of the Primary Structure of Single Chain Polymer Nanoparticles via Dynamic Covalent Chemistry (MolecularEVOLUTION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Cancer continues to be a major cause of death worldwide. While many drugs can reduce the size of tumors, their side effects commonly outweigh their benefits when the drug is administered by conventional methods. One promising approach to overcome this issue is to employ a synthetic enzyme to activate a prodrug into an active drug via a bioorthogonal reaction at the site of a tumor within a patient. Recent work by the group of Prof. E. W. Meijer at the Eindhoven University of Technology on amphiphilic polymers with pendant “sticky” hydrogen bonding moieties and pendant catalytic centers represents state-of-the-art synthetic enzymes. When these polymers are dissolved in dilute aqueous solutions, individual chains fold to form single chain polymer nanoparticles (SCPNs). The folding is thermodynamically driven by hydrophobic interactions and the dynamic aggregation of the “sticky” moieties. Although current SCPNs catalyze bioorthogonal reactions in water, they do not have well-defined high order structure like natural enzymes, instead exhibiting non-cooperative folding and open, elliptical structures. This lack of well-defined high order structure is due to a lack of polymer sequence control, as SCPNs reported to date are random or block copolymers. As a postdoctoral fellow in the Meijer group, I propose to make a new generation of biocompatible SCPNs that feature an aliphatic polycarbonate backbone that undergoes dynamic covalent chemistry in conjunction with the dynamic aggregation of the “sticky” pendant units to “molecularly evolve” the SCPN’s primary structure. This strategy will allow SCPNs to “correct” non-optimal sequences by giving each polymer chain the ability to reshuffle its primary structure, ultimately allowing the SCPNs to achieve lower energy folding states. I predict that the hydrophobic cores of the resulting evolved SCPNs will be more enzyme-like and thus better suited for catalysis and targeted drug therapy applications.
Self-healing geological construction materials and structures (GEOHEAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-22
End date: 2020-01-21
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Geological materials are used in significant quantities for construction purposes, structurally and for cladding, but are subject to damage, deformation and deterioration through natural weathering processes in combination with the stress state induced in service. As a consequence, structural performance can be reduced, durability is compromised and there may be aesthetic or heritage issues with regard to preservation of the original structural form. Currently, such issues are addressed either through initial overdesign, implementation of maintenance programmes, or both. The proposal seeks to explore the potential for providing such materials with the ability to self-heal – to automatically respond to damage or deterioration, instigating a healing process that restores or even enhances the desirable structural or aesthetic properties. Such technology will take inspiration from, and work in parallel with, current research into self-healing in cementitious, polymeric and other engineering materials. Previously, biological methods of treatment of geological materials have been employed, e.g. cementation through bacterial mineralisation of calcite, to enhance structural properties as well as to protect and conserve valuable structures. Similar technologies have been employed in the self-healing of cementitious materials. It is therefore envisaged, for the first time, to introduce the concept of biological self-healing to geological materials, combining the Fellow's expertise in geo-material conservation with that of the Host in self-healing materials and biomineralisation. A major part of this work is to identify and assess suitable healing mechanisms, and methods of triggering them, for the particular environments under consideration. Ultimately it is hoped that the technology would be applicable to both new and existing engineered structures comprising geological materials.

Keywords: self healing,durability and deterioration,biomineralisation,building materials