Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The European first generation of aquaculture SERS-based Biosensor (AQUASERS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-01
End date: 2020-02-29
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Aquaculture industry has turned essential to fulfil the growing demand of fish & shellfish seafood. With latest global production peaked at 171 M tones in 2016, aquaculture represented 47% of the total and a first sale value of $232 billion. Nonetheless, in spite of its importance, yet the early detection and monitoring of infectious disease agents during the whole process is not sensitive neither fast enough. Consequently, aquaculture industry faces up to $6 billion per year of productivity losses due to uncontrollable diseases, because they are not identified on time. In response, we have developed the first equipment for the detection of infection diseases within minutes in aquaculture. Our solution uses antibody-gold nanoparticles that specifically capture the infection disease agents present in water sample. Once combined, the agent-antibody-nanoparticles cross a microfluid chamber that after been irradiating gives an amplified light signal if the agent is present. This signal is immediately detected by surface-enhanced RAMAN spectroscopy (SERS). Thanks to the sensitivity of the SERS-technology, our equipment enables a fast treatment respond within 30 min for three of the main infections in Europe affecting salmon, abalone and flatfish. Thus, thanks to AQUASERS equipment we will reduce the productivity losses for salmon, abalone & flatfishs in Europe and Worldwide. Furthermore, after 4-year sales, our product will give net revenues of ~€66.84M, net profits of ~€46.64M and considering the investment of €2.69M, a ROI of ~17.33 euro per € invested.

Keywords: sers,cloud,real time,spectroscopy,patogen,disease agents,early detection,monoclonal,microfluidics,measurement,accuracy,easy to use,fish and shellfish infections,infections detection
Topological interactions as functional regulators of the eukaryotic genome: moving beyond intramolecular looping (TopoGenomics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Austria
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 2792500.0
EU funding (EUR): 2792500.0
Participants: 1
Project status: SIGNED

Topological interactions between distant DNA segments play fundamental roles in the function of eukaryotic genomes. While tremendous progress has been made in understanding the molecular mechanisms shaping intramolecular chromosome loop structures, limitations in our ability to distinguish specific chromosome conformations between paired molecules has hindered research into the role of interactions across separate chromosomal DNA molecules. Our recent development of an approach allowing analysis of contacts between sister chromatids now provides an opportunity for research into topological interactions to enter a new phase. Initial analyses with sister chromatid-sensitive Hi-C (scsHi-C) have indicated enormous potential to elucidate the mechanisms by which sister-chromatid conformation controls processes as varied as DNA repair, gene regulation and the segregation of mitotic chromosomes. To fulfil this potential, we will now develop next-generation scsHi-C technology to generate high-resolution genome-wide conformation maps of sister chromatids, along with the establishment of a machine learning-based computational framework to systematically detect topological structures in sister chromatids. This will be complemented with an imaging-based super-resolution approach to trace sister-chromatid fibers in thousands of individual cells. These core advances will allow us to map distinct sister-chromatid contact domains and identify associated molecular signatures, understand how loop-extruding and cohesive cohesin interact to shape replicated chromosomes, and determine how epigenetic modifications control pairing between sister chromatids. Together, these developments will allow us to make key advances in understanding a fundamental yet largely neglected aspect of chromosome biology—how replicated sister chromatids topologically interact to support maintenance, expression, and segregation of eukaryotic genomes.

Keywords: genome topology,chromosome conformation capture,hi c,machine learning,dna repair,gene regulation,chromosome segregation,cell division,cohesin
IcoCell− Chassis for Enhanced Mammalian Cell Line Development and Engineering (IcoCell)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Estonia
Call: SME boosting biotechnology-based industrial processes driving competitiveness and sustainability (H2020-SMEINST-1-2014, 2014)
Start date: 2015-04-01
End date: 2015-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The opportunity to focus on the production of biopharmaceuticals is often taken from SMEs since huge amount of resources is required for the development of high-producer cell lines. We envision that our parental cell factories will increase the efficiency of cell line engineering and will effectively reduce the time-to-market for mammalian cell-based products. It allows SMEs to leverage their traditional strengths of adaptability and creativity, and to develop novel products for biotechnology industries.

Keywords: competitiveness of the sme,mammalian cell line development,protein production,recombinant antibodies
Deciphering type 2 innate lymphoid cell/epithelial progenitor cell crosstalk in pancreas regeneration and neoplasia (PanILC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Regulation of the epithelial stem cell compartment is critical for tissue homeostasis and regeneration. Consequently, imbalance in this process, through acquisition of somatic mutations for instance, may give rise to tumorigenesis. Emerging reports reveal that regulatory T cells (Tregs) can modulate epithelial stem cell dynamics in the skin, while type 2 innate lymphoid cells (ILC2s) are known to influence tissue-regeneration. Recent work in our laboratory has elucidated that ILC2s crosstalk is essential for local Tregs expansion. We hypothesize that tissue-resident ILC2s influence the stem cell niche by recruiting and regulating Tregs, and that such a mechanism could be key to tissue regeneration as well as tumor development. Preliminary data in the lab suggest that the intraperitoneal injection of the potent ILC2 inducer IL-33 in mice activates ILC2 in the pancreas, and that a concomitant increase in Treg numbers is observed in this organ. This raises the possibility of the existence of a crosstalk between ILC2s and Tregs in the pancreas upon inflammation, such as in the case of pancreatitis. Given the considerable attention brought lately on the ability of Tregs to develop tissue-promoting capacities, we postulate that regeneration of the exocrine pancreas following pancreatitis may be driven by such pancreatic Tregs upon their “priming” by ILC2. The present project will therefore focus on understanding the role of ILC2 and Tregs and their possible crosstalk in pancreatitis development, as well as in the regeneration process that follows, i.e. the interaction of these immune cells with epithelial progenitors. As pancreatitis is a major risk factor for the development of pancreatic cancer, the resulting observations will then be extended to the analysis of the role of ILC2/Treg crosstalk in tumor development in an orthotopic mouse model of pancreatic tumours as well as in a genetic mouse model of pancreatic adenocarcinoma.

Keywords: ilc2,treg,pancreatitis,pdac
Shear Stress Induced Arterial and Venous Specification through Piezo1 (SAVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-07-01
End date: 2020-11-18
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Arteriovenous malformations (AVMs) are characterised by abnormal connections between arteries and veins due to defects during vascular remodelling. Although often asymptomatic, AVMs can cause intense pain and patients affected present higher risk for strokes and aneurysms. Hereditary AVMs have a prevalence of 18 in 100000 people causing a two-fold increase in mortality in patients younger than 60 years of age. Hereditary AVMs are linked to defective Notch/BMP signalling, however they represent less than 10% of cases. The majority of AVMs do not present genetic mutations and remain idiopathic. Asides Notch/BMP signalling, vascular responses to haemodynamic forces generated by blood flow are crucial regulators of blood vessel formation. The passage of fluid results in physical forces on the endothelium, i.e. shear stress, which activate signalling cascades inside the cells necessary for vascular remodelling. Endothelial cells sense shear stress through proteins localised on their plasmatic membrane. The calcium channel Piezo1 is required for shear stress induced calcium signalling and its ablation resulted in serious vascular defects. Both shear stress and calcium signalling are known to affect the activation of Notch, a pathway essential during the process of arterial-venous specification and vascular remodelling. Therefore we hypothesise that Piezo1 plays a crucial role in arterial venous specification and onset of AVMs by modulating Notch signalling activation. This proposal utilises an interdisciplinary approach to decipher the new targets underlying the intricate and still unknown interaction of physical and molecular mechanisms responsible for defective arterial venous specification. The results of this research will potentially provide appealing diagnostic and therapeutic opportunities for both hereditary and idiopathic AVMs.

Keywords: piezo1,notch signalling,shear stress,avms,arterial venous specification
The Historic Urban Landscape of European Cathedral Cities: a transnational approach towards an understanding of a shared European heritage (URBS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2023-01-30
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Many European cities are characterised by the presence of a medieval cathedral within a settlement comprising of civic, religious and domestic buildings, enclosed by vestiges of urban walls and gates of antique or medieval origin. They can be small settlements as well as capital cities, with variable degrees of conservation of the historic built environment, but they all have similar patterns in their historic landscape created by a common history and culture. There are many challenges in the curation, including conservation and presentation to the public, of cathedral cities: inspired by the UNESCO (2011) declaration on managing change in the Historic Urban Landscape, which promotes a comprehensive survey of tangible and intangible heritage and includes the ways in which people absorb and react to their surroundings, URBS will focus on how inhabitants and visitors perceive, experience and value the historic landscape of cathedral cities. The first aim of the project is to develop a set of narratives and mapping that addresses the experience of cathedral cities from several perspectives simultaneously, applying historic landscape methodologies together with qualitative research methods to four case studies: Girona (Spain), City of London (UK), Palermo (Italy) and Poitiers (France). The second aim of URBS is to investigate and demonstrate how cathedral cities in Europe, despite having their individual character and spirit of place, have similarities in their topography and historical layers. The third aim of URBS is to train the fellow in qualitative research methodology and in the emerging technology of cultural mapping, giving her experience of leadership of collaborative groups; she will thus develop a full range of skills and experience which will allow her to design and direct future research in participatory approaches to the historic urban landscape.

Keywords: historic urban landscape,cathedral cities,urban history,heritage,medieval archaeology,cultural,mapping,participation,theory of space,archaeology of buildings
ERA Chair position in Materials Research in Extreme Environments (MATTER)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Estonia
Call: ERA Chairs (H2020-WIDESPREAD-2018-04, 2018)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 2499750.0
EU funding (EUR): 2499750.0
Participants: 1
Project status: SIGNED

The overall objective of the MATTER project is to hire excellent researchers to facilitate structural changes in University of Tartu (UTARTU) by establishing an integrated ERA Chair in Materials Research in Extreme Environments (MATTER) to increase the research excellence in advanced materials modelling, biomedical engineering and nanomanipulation and exploitation of materials science in biomedical applications and nanomaterials. For achieving the main objective, the following activities will be implemented: • Recruitment of the ERA Chair (R3-R4 level), three established researchers (R3 level), engagement of 3 post docs, 3 ESRS and establishing collaboration with existing 8 research groups Formation of International Advisory Board (IAB), implementation of 3 IAB workshops • Defining the MATTER’s key long-term strategies – research strategy, knowledge and IP management strategy, exploitation and sustainability strategy • Increasing research excellence by implementation of the scientific strategy by ERA Chair team and establishing and coordination of collaboration network of high level science and education centers: organization of 10 incoming and 14 outgoing visits • Improving of Ph.D. curriculum by introducing innovation and technology management entrepreneurship module, mentoring and coaching of ESRs on entrepreneurial aspects by the ERA Chair and the team • Increasing the opportunities for interdisciplinary learning and promoting entrepreneurship, through innovation and technology management entrepreneurship module, industry traineeships, mentoring and coaching by ERA Chair team • Create high-profile industrial collaboration via: Implementation of at least 10 onsite and off-site demo and info-days 7 short-term exchange of senior researchers, 6 internships and industry co-supervision of ESRs • Increase the visibility of the MATTER research excellence via: 3 high-level international conferences/workshops, 3 summer schools, posters/presentations/interve

Keywords: materials in extreme environments,biomedical engineering,advanced materials modelling,nanomanipulation,biomedicall applications,nanomaterials,era chair
EXPLORATHON 2021 - European Researchers' Night in Scotland (EXPLORATHON 2021)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020bis, 2020)
Start date: 2021-05-01
End date: 2022-02-28
Duration (months): 10.0
Total project cost (EUR): 370096.0
EU funding (EUR): 209606.0
Participants: 5
Project status: CLOSED

Our proposal builds on the success of EXPLORATHON in Scotland from 2014 to date and will deliver a blockbuster edition of the NIGHT across all of Scotland, utilizing both digital events as well as face-to-face events. Our pan-Scotland partnership learned significant lessons in our online only delivery in 2020 which will allow us to reach more audiences, leave a lasting digital legacy and upskill researchers in how to achieve digital as well as traditional engagement. We will engage with audiences in the main urban centres in Scotland as well as in hard to reach audiences in rural areas and geographically isolated communities in the Highlands and Islands. We will use our full expertise of marketing, social media and styles of engagement to mobilise our researchers and train them to engage with the public. We will use a variety of different styles of engagement from comedy to drama, to online and fun hands-on science experiments to enthuse the public about research and researchers. Working with key partners across Scotland we will showcase to secondary and upper primary aged school children the array of research careers that are on offer and bust myths about researchers.

Keywords: public engagement with research,inspiring young minds,reaching new audiences,innovative,engagement,promoting research careers
MARine MAnagement and Ecosystem Dynamics under climate change (MARmaED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Germany,Norway,Finland,Finland,Norway,Finland,Norway,France,Netherlands,Netherlands,Denmark,United Kingdom,Denmark
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2015-10-01
End date: 2019-09-30
Duration (months): 48.0
Total project cost (EUR): 4073903.28
EU funding (EUR): 4073903.28
Participants: 16
Project status: CLOSED

The proposed European Training Network, MARmaED, connects science, policy and people and transcends national borders, disciplinary barriers and sectorial divides. By building a greater knowledge base and train the next generation of scientists to think across disciplines, MARmaED contributes to reinforce Europe’s position as a global leader in marine science and ensure blue growth and sustainable exploitation of marine living resources. The objectives of MARmaED are: - To increase the marine scientific knowledge base by integrating traditionally separate scientific disciplines within a unified learning platform. - To train a new generation of innovative researchers with interdisciplinary experience and skilled in promoting marine science to a wide audience. MARmaED integrates education and research in complementary marine sciences in Norway, Finland, Denmark, the Netherlands, Germany and France. Specifically, the network links state-of-the-art competences in genetics, ecophysiology, ecology, climatology, physical oceanography, statistics and economics. By so doing, the network unifies essential disciplines needed to achieve a good understanding and management of the marine environment. The research will provide new insights into how the cumulative stress from biodiversity loss, climate change and harvesting affects Europe’s complex marine systems and the consequences for optimal resource use - knowledge that is needed for sustainable, ecosystem-based management. MARmaED has a strong focus on training, with a mobility programme facilitating inter-disciplinarity and training modules of transferrable skills such as communication. Targeted secondments in the non-academic sector will provide the network’s students with inter-sectorial training and favourable employment opportunities. MARmaED will thus create novel standards in the training of a new generation of multi-disciplinarily skilled and creative marine scientists, fit to address Europe’s future challenges.

Keywords: management of living resources,ecosystem based management,bio economics,anthropogenic drivers,multiple stressors,environmental genomics,climate change,socio economics
Dynamic Urban Environmental Exposures on Depression and Suicide (NEEDS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2022-01-31
Duration (months): 58.0
Total project cost (EUR): 1499902.5
EU funding (EUR): 1499902.5
Participants: 1
Project status: CLOSED

19% of the Dutch population suffer from depression and people affected by depression have a significantly higher suicide risk. Although the World Health Organization attributes modifiable environmental factors including urban environments (i.e. the built, natural and social environments) to health outcomes, they are largely disregarded as either stressors or buffers in scientific debates on depression and suicide. A limitation of current studies is that urban environmental features are often restricted to the neighbourhoods within which people live. This may result in incorrect conclusions about health-influencing factors and inappropriate policies. Human life ultimately unfolds over space-time; people are exposed to multiple urban environments not only during daily life but also over the course of their lives. It is this, not yet assessed spatiotemporal interplay of urban exposures that might revolutionize health assessments. This research aims to understand the interactions between urban environments, depression and suicide in the Netherlands. The scientific breakthrough will be dynamic health geographies embedded in space-time by two innovative case studies. We will investigate the following research questions: What are the associations between depression and the built, natural and social urban environments along people’s daily space-time paths? And what are the associations between suicide and the built, natural and social urban environments of previous residential locations? A multidisciplinary approach combining health, geographic information science and urban geography will lead to this breakthrough. It will be grounded on cutting-edge smartphone-based human tracking, health register data and spatiotemporal modelling. Knowledge about dynamic urban exposures is key to revealing disease aetiologies, advancing health preventions and formulating policies supporting a healthier urban living.

Keywords: urban environmental exposures,depression,suicide,time geography