Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
(Re)distributive Politics after the AI Revolution (REPAIR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Recent advancement in Artificial Intelligence (AI), such as the release of ChatGPT, has intensified concerns about the future of work. Studies suggest that ChatGPT could already fully replace up to 33% of jobs, with high-skilled workers facing the greatest risk. Scholars warn that AI automation may threaten the central role of work as the primary means of income distribution, potentially leading to an era of widespread poverty and intensified inequality. In response, many countries are seeing growing political momentum to reform welfare in anticipation of rapid changes in the world of work. Yet, political science has yet to examine how welfare states will respond and adapt to the labor market challenges posed by AI. This project is the first comprehensive analysis of welfare state politics in the age of AI, examining how institutions, and the supply and demand of welfare politics shape responses addressing AI's impact on the labor market. Employing a multimethod approach that integrates natural language processing and multilevel models, it aims to address the central question: How does AI reshape welfare politics across OECD countries? The project will examine in real-time how welfare policies and politics are evolving in response to the rapid changes brought by AI. The project will: (1) shed light on different welfare systems will be affected by AI, (2) map the political landscape of party positions and framings of AI, (3) examine public support for different welfare reforms, (4) develop a new understanding of how welfare systems will adapt to the challenges posed by AI. By exploring how existing systems shape the adoption of AI, the project moves away from techno-deterministic perspectives to focusing on the active role of policies in shaping the future. The project breaks new academic ground by developing a new area of study, and offers actionable recommendations to policymakers on viable paths for welfare reforms to address the challenges posed by AI.
Laser induced nanojet functionalization of two-dimensional materials for sensing and energy harvesting applications (LANAFUSEHA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Greece
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-07-30
End date: 2025-07-29
Duration (months): 24.0
Total project cost (EUR): 169326.72
EU funding (EUR): 169326.72
Participants: 2
Project status: SIGNED

The project will make an impact in important societal needs in the fields of energy harvesting and sensing for environmental, safety, and medical applications, which are relevant to the entire global population. The development of any of these high-tech areas is associated with the use of new materials. The scope of this proposal is to advance 2D materials by adding to them novel functionalities for improved energy-harvesting and sensing applications. Such 2D materials as graphene and transition metal dichalcogenides were selected for functionalization. The creation of nanopores or the attachment of chemically active compounds will significantly expand the capabilities of such materials, for example, it will enable the development of universal chemical sensors for the detection of volatile organic compounds. The project proposes to solve an important problem of functionalization, localized on nanoscale, which will allow minimizing the proposed devices. The disruptive technique to be used in this proposal for nanometer-precision patterning of 2D materials is based on one of the latest nanophotonics advancements, the photonic nanojets. It is possible to functionalize 2D materials by laser with spatial resolutions significantly lower than the diffraction limit, as light in a photonic nanojet can be concentrated into a volume that is one order of magnitude smaller. The project provides for a fairly simple and scalable technology. The low technological hazard of the method and invariance for materials are the basis for economic feasibility. New materials and devices arising from this project will be exploited by the industry, strengthening the EU economy and technological excellence in the fields of energy, electronic technology, health industry, security, environmental and industrial monitoring

Keywords: laser functionalization,optical tweezers,nanojet,graphene,dichalcogenides of transition metals
Targeting DNA Damage Response and Metabolism for Precision Medicine in Rheumatoid Arthritis (DDRAsTic)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: SIGNED

Rheumatoid arthritis (RA) is an autoimmune disease that affects millions of people worldwide, and its negative health burden is accelerating in the ageing population. Despite many available treatments, up to 40% of RA patients do not respond sufficiently to current therapies and the needs for a precision medicine approach and new treatments are pressing. The complexity of RA and unselective mechanisms of action of existing drugs are challenges. Current treatments also have unintended adverse effects because they affect healthy cell types in the body. The proposed project “DDRAsTic” focuses on a particular enzyme called MTHFD2, which plays a crucial role in the metabolism of folate and DNA damage response of activated T cells. Recent research and preliminary data, suggest that MTHFD2 is overactive in RA patients. DDRAsTic aims to address the hyperactive T-cell responses at the core of RA by targeting MTHFD2 with novel inhibitors that spare essential components, thereby minimizing the risk of toxicity and adverse effects. In parallel, DDRAsTic seeks to understand the underlying reasons for the limited efficacy of current RA treatments and explore potential biomarkers that can predict how patients will respond to standard therapies, with a specific focus on understanding the involvement of MTHFD2. The aim is to introduce a precision medicine approach in RA and identify a novel treatment. To achieve this, DDRAsTic adopts a multidisciplinary approach and uses patient-derived specimens, RA animal models and bioinformatics analysis from large cohorts of RA patients to undergo advanced imaging, cellular and molecular techniques. Overall, these analyses aim to provide insights into MTHFD2's regulatory role in abnormal immune responses and advance RA treatment by introducing precision medicine approaches and overcoming treatment toxicity.

Keywords: dna damage response,mthfd2,rheumatoid arthritis,small molecules inhibitors,precision medicine,metabolism
Strategies and Technologies for United and Resilient Critical Infrastructures and Vital Services in Pandemic-Stricken Europe (SUNRISE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Resilient Infrastructure
Action type: Innovation actions
Countries involved: Spain,Italy,Slovenia,Germany,Luxembourg,Austria,Ireland,Serbia,Israel,France,Estonia,United Kingdom,Belgium,Czechia,Cyprus
Call: Ensured infrastructure resilience in case of Pandemics (HORIZON-CL3-2021-INFRA-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 11643258.75
EU funding (EUR): 9542736.0
Participants: 44
Project status: SIGNED

The COVID-19 pandemic has highlighted the importance of the continuity of vital services, has shown the need to work together for the common good. It has proven that a pandemic is not only a health crisis and that it does not only disrupt Critical Infrastructures (CIs), but that there is an extremely important link between the resilience of CIs and our societies. The economic crisis caused by the pandemic also provides a unique opportunity to jointly ‘build back better’ with the focus on sustainability and green recovery. SUNRISE will facilitate active collaboration of CIs across Europe to share best practices and jointly tackle future pandemics. By Q3/2025, this collaboration will result in a new stable working group for resilience to pandemics with at least 100 members. With a group of 4 CI authorities, 16 CI operators, 3 other CI stakeholders, 4 experts in Social Sciences and Humanities, 2 experts in epidemiology and climate extremes, and 12 security researchers and SW developers, we will: (1) Identify pandemic-specific vital services and CIs, their dependencies, risks, cascading effects, and effective measures to tackle them at European level. (2) Develop a comprehensive strategy (TRL8) and four innovative tools (TRL7) ensuring greater availability, reliability, security, robustness, trustworthiness, cost-effectiveness, climate-friendliness, and continuity of pandemic-specific vital services in Europe: Tools for risk-based access control, resource demand prediction and management, cyber-physical resilience, and remote infrastructure inspection. (3) Pilot the results in operational environments of the CIs while tackling some of their biggest pain points exposed by the current pandemic. (4) Promote our approach across Europe to ensure a united front and resilience of CIs to pandemics. We will carefully consider legal, ethical, societal, economic, and climate aspects, ensuring that our results address not only the needs of the CIs, but also those of our society.

Keywords: ci resilience,pandemics,ci collaboration,resource demand prediction and management,green pass risk based access control,remote infrastructure inspection,cyber physical resilience
Building a Global Criminal Justice System at the Domestic Level (JOINEDUPJUSTICE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands,Canada
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2332184.0
EU funding (EUR): 2332184.0
Participants: 3
Project status: SIGNED

JOINEDUPJUSTICE develops parameters for a coordinated system of global justice at the domestic level. While the project’s focus is on international criminal law (ICL), international refugee law (IRL) is the starting point; it is the metaphorical canary in the coal mine that flags up questions at the heart of ICL. Many of the domestic prosecutions of international crimes (crimes against humanity, war crimes, genocide) are asylum related. This comes with problems. First, article 1F(a) of the Refugee Convention, (exclusion clause), stipulates that those who are suspected of having committed international crimes are undeserving of protection and should be prosecuted. There is no uniform understanding of ‘undeserving’. At the same time, ICL lacks an overarching policy of who is 'deserving' of prosecution. Many excluded asylum claimants remain unprosecuted and exist in a legal limbo. Second, asylum related prosecutions have a distorting effect. It comes with a focus on low-level and ‘low cost’ defendants (from weak countries). Third, it hampers developing a long-term approach to ICL enforcement. The project consists of 5 work packages and 9 subprojects: (i) through empirical research in 8 focus countries and comprehensive case-analysis it maps who is deserving of prosecution whilst scrutinizing the ‘enemy of mankind’ narrative, ‘no safe haven’ and ‘end to impunity’ goals, (ii) it clarifies the scope of ‘undeserving’ and draws the line between criminal complicity and non-criminal association, addressing the ICL-IRL mismatch that leaves many in limbo, (iii) it proposes a system of ‘jurisdiction designation’ based on subsidiarity and burden-sharing plus a settlement proposal premised on a ‘right to start again’, (iv) allows for policy integration, (v) and synthesises findings into an account of coordinated global criminal justice. The project’s ambition, scope and methodology will lead to a step change in international criminal justice where the future is domestic.

Keywords: international criminal law,international crimes,prosecutorial policy,icc,universal jurisdiction
Anthropogenic Residue Traces In Speleothems: new methodology for exploring Temporality of human use in rock art Sites (ARTISTS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Canada
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 3
Project status: SIGNED

Rock art, one of humanity’s earliest symbolic expressions, is considered a milestone in human evolution. Despite extensive global research, little is known about the specific patterns and rhythms of how past societies used rock art sites. ARTISTS project seeks to understand patterns of use of rock art sites, which hold a special place in prehistoric societies' physical and symbolic territories through three main objectives: 1) Identify and characterize anthropogenic traces (such as chars) from complementary sites (geography, climate and chronology) in Spain and France using an integrated multi-method protocol, 2) Document the temporality of rock art site use with micro-chronological precision and calendar accuracy, and 3) Synthesize findings to understand the dynamics of site use from archaeological and anthropological perspectives. To achieve these goals, Dr. Vandevelde will study sooty speleothems, which are exceptional archives for micro-chronological research. They offer precise radiometric dating and high-resolution paleoenvironmental data through annual laminae. They also serve as anthropogenic records, capturing traces of human activity, such as soot from lighting, allowing the construction of a relative chronology of visits at a site. These detailed chronologies can reveal occupation patterns on an annual scale, providing groundbreaking insights into human mobility. By targeting rock art sites, ARTISTS will shed new light on occupation dynamics of sites visited for symbolic activities. A decorated cave is not a vitrified site, and recent studies show that the temporal complexity of rock art sites is much greater than previously believed. By combining innovative in-lab and on-site multidisciplinary methods from archaeology and geosciences, ARTISTS can reveal this complexity with unprecedented accuracy. For the first time, integration of rock art sites into annual or multi-year cycles of nomadism will be discussed directly from archaeological data.

Keywords: european archaeology,archaeology of fire,pyroarchaeology,high temporal resolution,temporality,rock art
Evaluation of Feynman integrals for scattering observables relevant for gravitational physics (GravityIntegrals)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: CLOSED

This work focuses on the evaluation of integrals encountered in Post-Minkowskian perturbative expansion of gravitational observables, using the modern scattering amplitude techniques. In particular, we encounter integrals having a very complicated analytic structure in the form of integrals containing elliptic curves. These integrals are one of the main bottlenecks in the present computations. The aim is to utilise studies from collider physics to evaluate these integrals.

Keywords: scattering amplitudes,elliptic feynman integrals,multi loop feynman integrals,gravitational observables
Method for Integrated All-Optical Biological Analysis at Scale (MIOBAS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-10-01
End date: 2026-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The advent of light-emitting sensors and light-driven actuators has profoundly transformed the fields of biology and medical science over the past three decades. These innovations enable the manipulation and monitoring of various physiological processes using light with remarkable precision in both time and space. Applications include the study of signaling and cell trafficking in healthy and malignant tissues, the unraveling of causal relationships within neural networks or the assessing the effects of pharmaceutical compounds. To fully harness the potential of these so-called optogenetic technologies, there is a pressing need to create integrated optical systems offering both 3D imaging and precise light-targeting of specific regions at scale. Within the framework of the ERC, we have successfully engineered a unique system designed for the optogenetic probing of small vertebrate brains (zebrafish larvae) at cellular resolution. Our proposal expands upon this earlier achievement, by evolving it into a versatile all-optical platform tailored for biologists and biomedical laboratories. This platform will seamlessly integrate cutting-edge optical systems with automated data analysis through artificial intelligence (AI) techniques. Anticipating a vast array of applications, we envision that this platform will prove invaluable e.g. in the realms of neuroscience, developmental biology, and cancer research. Its multifaceted capabilities will empower researchers to unlock new insights and accelerate advancements in these critical scientific domains.
Druggability of G-quadruplexes, promising modulators for antimicrobial resistance (The G-Q-reat ESKAPE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

The antimicrobial resistance (AMR) is an underrated problem promoted by widespread misuse and massive use of antibiotics. Thus, the health systems are facing enormous costs to treat nosocomial infections due to AMR bacteria. In particular, six highly virulent bacteria (E.S.K.A.P.E.) are the main responsible for worldwide nosocomial infections. In the last years, our research strategies to discover and develop new clinically relevant antibiotics lacked effectiveness. As a result, we are unable to efficiently treat AMR infections and are unprepared to face an AMR bacteria outbreak. One possible strategy is to target bacteria G-quadruplexes (bGQs) which are highly conserved DNA/RNA secondary structures pivotal for bacteria duplication, transcription and translation. This strategy is particular effective because, when a new pathogen emerges, its DNA/RNA genome is first disclosed through sequencing, hence the ability of quickly designing new drug candidates based only on this information will be a powerful tool to face a new epidemic/pandemic. Furthermore, the human GQs (hGQs) were largely investigated as possible target for anticancer treatment thus the interest in bGQs raised later and with less intensity than hGQs. In addition, most GQs modulators bind G-quartets top by π-stacking interactions and the druggability of GQs loops/grooves was still not addressed. In this context, the multidisciplinary of G-Q-reat ESKAPE project aims to provide a novel and effective strategy to contrast AMR by targeting bGQs and to expand the knowledge on bGQs.

Keywords: g quadruplex,antimicrobial resistance,in silico screening,molecular dynamics,biophysics