Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Improving Health Research in EU through FAIR Data (FAIR4Health)

Framework: Horizon 2020 — Science with and for Society
Programme: Develop the accessibility and the use of the results of publicly-funded research
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Spain,Italy,Spain,Spain,Spain,Switzerland,Switzerland,Serbia,Belgium,Türkiye,Netherlands,United Kingdom,United Kingdom,Portugal
Call: Encouraging the re-use of research data generated by publically funded research projects (H2020-SwafS-2018-1, 2018)
Start date: 2018-12-01
End date: 2021-11-30
Duration (months): 36.0
Total project cost (EUR): 2999053.75
EU funding (EUR): 2999053.75
Participants: 22
Project status: CLOSED

The overall objective of FAIR4Health is to facilitate and encourage European Union Health Research community to FAIRify, share and reuse their datasets derived from publically funded research initiatives through the demonstration of the potential impact that such a strategy will have on health outcomes and health and social care research. FAIR4Health vision for year 2020 is a vast, open community of EU health research institutions fully engaged to the Horizon 2020 ORD Mandate enhancing their knowledge-based economy and their research excellence thanks to the application of the FAIR data guiding principles. High quality health research and routine care data will be shared and reused in a secure, controlled and legally compliant environment in order to accelerate knowledge discovery while reducing the bias and enhancing the strength and quality of the scientific evidence raised by the FAIR4Health community members. Furthermore, a community of data scientists from both public research institutions and private companies will be attracted to develop advanced analytical solutions able to communicate with the FAIR4Health platform in order to provide data-driven innovative services that will enable a seamlessly application of the new evidence raised into the clinical practice. FAIR4Health has four specific objectives and will aim to deliver an effective outreach strategy at EU level, a FAIR data certification roadmap, an intuitive user-centered FAIR4Health platform and to demonstrate the potential impact that the implementation of such FAIR data strategy will have in terms of health outcomes and health research.

Keywords: health and social care research,e health services,interoperability,health informatics,distributed data mining
The Ultimate Therapy for the Oral Lichen Planus (RIVELIN-CLO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: SIGNED

Oral lichen planus (OLP) is an immune-related disorder affecting 84M people worldwide (10M in EU and USA). OLP is a chronic condition which can ultimately lead to precancerous lesions, while patients suffering from it may struggle daily with painful and/or burning sensations in the oral mucosa, being thus kept from living their normal lives. Since there is no approved cure for OLP, the primary goals of its treatment are the alleviation of symptoms and the minimization of mucosal damage from erosive lesions. Current therapeutic options involve the use of topical corticosteroids (typically Clobetasol). However, the ways of use available in the market show lack of adherence to the mucosa and there is a high chance that the product is spread to other areas (which results in reduced efficacy and potentially causing undesired topical and systemic side effects). Our Danish company AFYX Therapeutics A/S was founded in 2014 with the aim to develop innovative approaches to treat mucosal diseases such as OLP. We have developed our first product incorporating an innovative technology (using an electrospinning process): the RIVELIN®-CLO patch. It’s the first to have been developed exclusively for the treatment of OLP, and its unique properties include self-adherence to the oral tissues (2h of topical drug application); occlusion of the lesion; lower bystander toxicity (Clobetasol is prevented from being spread by saliva) and the correct dosing every time. Clinical Phase IIb trials of the patch are ongoing with clinics and hospitals across EU and US and through this project we aim to guarantee that RIVELIN®-CLO is a success from a technical, commercial and financial perspectives, before launching it to the international markets. Five years after market launch, we expect to gather 7% of the EU and US combined OLP treatment market share, generating €22.6M revenues to our company and increasing our staff to 40 employees and generate new IP to venture new markets with our technology.

Keywords: oral lichen planus,immune disorder,oral mucosa,oral medicine,topical corticosteroids,clobetasol,electrospinning technology,drug delivery,bioadhesive,biodegradable dual layer
Adapting fishways to hydrological and climatic uncertainty (Smart Fishways)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-12-21
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Current society needs a large volume of fresh water to keep its present lifestyle. This has led to the massive installation of barriers in rivers, causing fragmentation of habitats and ecological alteration of freshwater systems. Fragmentation specially affects fish, as they require different environments to complete their life cycles. Stepped fishways are the most extended solution to ensure fish movements. Unfortunately, their efficiency is sensitive to the equilibrium between biological and hydraulic aspects, which, is often far from acceptable. The natural variability of rivers modifies the hydraulic conditions within fishways, affecting the biological responses and their principal objective: allow the free movement of fish. This research project aims to (1) assess the effect of hydrological variability in stepped fishways and for this (2) to develop a technological and methodological framework to monitor fishways performance in real time which combines fish biology, hydraulics and sensor networks. This will allow creating a new generation of smart fishways capable of self-deciding their optimal configuration when faced to hydrological uncertainty. The study of the effect of variability will allow to adapt and propose specific solutions to some of the challenges that need to be faced the coming years, such us accomplish the requirements or Water Framework (2000/60/EC), Habitats (1992/43/EEC) or Renewable Energy Directive (2009/28/EC), and will help to define solutions and actuation plans for the possible modifications in the water cycle produced by the climatic change, in line with EU Adaptation Strategy.

Keywords: fishways,hydrological variability
Collective intelligence to disrupt the knowledge management (ZAPIENS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-05-01
End date: 2021-08-31
Duration (months): 28.0
Total project cost (EUR): 2169942.5
EU funding (EUR): 1487966.38
Participants: 1
Project status: CLOSED

While the second wave of the Internet development was about social networks and social economy, the third wave of the Internet will be about Internet of Everything (data) and Knowledge. Through the new market of the knowledge management (KM) -TAM of € 175 billion ($140) and growing-, organizations are seeking to acquire or create potentially useful knowledge and to make it available to achieve maximum effective usage to positively influence organizational performance. 80 percent of CEOs who are investing heavily in artificial intelligence also publicly pledged to retain and retrain existing employees. ZAPIENS is an Artificial Intelligence unit that, using Natural Language Processing, trains people, identifies talent, delivers "people analytics" and makes the process of gathering and sharing knowledge seamless. What ZAPIENS is doing is beyond of the current state-of-the-art: we're testing the most advanced techniques and models in real-world data provided by our customers together with the symbolic representations of knowledge and qualitative feedback they give. We're entering in unexplored AI applications but the results we have today are very promising. We already have a fully functional version of our training and peer-to-peer sharing information tool (TRL 8). But in terms of technological innovation (linked to the AI), our stage of development is equal to TRL 7. ZAPIENS has been growing sales from incorporation at 3x in annual basis. For 2018 we expect € 1 million in revenue (half already secured), growing to € 24 million by 2021. This means that, three years after the inception of the H2020 phase-2, ZAPIENS will have an aggregate of € 35+ millions in revenue. ZAPIENS can be the market leader because is the first mover. We have the foundations to build a global game-changer company. Now, we need to speed-up our development and growth, that's why we're asking for the SME Instrument support.

Keywords: natural language processing,data and knowledge management,artificial intelligence,organization management
From bottle to stone. Recyclable engineered stone for countertops. (SUSTONABLE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

SUSTONABLE is a revolutionary thin and ultra-lightweight building material developed and patented by INNSTECH, with the physical look and feel of engineered (quartz) stone. The product has a high scratch and impact resistance. The end product weighs 1/3 of current engineered stone while using only 20% of the raw materials. In recent 30 years composite stone has been replacing natural stone in the kitchen. Artificial stone is a factory-made alternative with all the beauty of the natural material and the added benefits of resistance to staining, consistent colour, ease of handling and cutting. It is a fast-growing segment with 400M m2 countertops sold and will continue to gain share from less desirable materials such as HP Laminate worktops, which still represent 50% of the market as the cheapest option. We at INNSTECH have pioneered the way to use recycled PET from plastic bottles and create a thin composite stone-like material that is recyclable with a very efficient process, and still having the desired look, feel and properties of current composite stone. Moreover, we can drastically reduce SUSTONABLE price than comparable materials in the market -up to 50% cheaper than top vendor engineered stone, e.g. Silestone with sales €548M/yr. Our vision is to deliver the next generation stone surface materials ready for the new sustainable circular economy, while positioning SUSTONABLE in the low-cost segment of the market offering the high-quality functional properties of competitors. Having already successfully run our process in a pilot plant, SUSTONABLE has produced approximately 450 slabs of 250x80cm. The business strategy is first to prove the technology in the kitchen market by building and operating a medium scale plant with a capacity of 400,000 m2/year, reaching €12.6 million revenues in 2024. The kitchen countertop leader in NL, Dekker (3500 countertops per week), has signed up as a co-investor in the project with the intention to sell and install SUSTONAB

Keywords: engineered stone,recyclable materials,countertops,kitchen,green building
Gene overdosage and comorbidities during the early lifetime in Down Syndrome (GO-DS21)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,France,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Understanding causative mechanisms in co- and multimorbidities combining mental and non-mental disorders (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2025-06-30
Duration (months): 66.0
Total project cost (EUR): 5965967.75
EU funding (EUR): 5965967.75
Participants: 12
Project status: SIGNED

The aim of the project is to elucidate etiological mechanisms involved in the appearance of obesity, and intellectual disability comorbidities in Down syndrome (DS). With its incidence of 1 in 1000 births, DS offers a great opportunity to uncover common/novel mechanisms because it is associated with a higher risk to develop several obesity, and intellectual disability. The increased risk to develop this combination of comorbidities in DS, suggests that specific genetic or epigenetic mechanisms associated with trisomy 21 (the cause of DS) predispose to this comorbidity. For this aim, GO-DS21 will have the following objectives: 1) To determine age-related comorbidity patterns observed over the early lifetime (before age 45) in persons with Down syndrome (WP1). 2) To identify specific physiological biomarkers (WP4), and regulatory and epigenetic signatures (WP5) in human, cellular and animal models. 3) To decipher the contribution of environmental factors (stress, diet, exercise) to trisomy 21 obesity/ID comorbidities in preclinical models (WP2, 3). 4) To investigate the effects of overdosage of three Hsa21 candidate genes (DYRK1A, MRAP, NRIP1) to explain comorbid patterns in mouse models (WP3). 5) To integrate multilevel data from human patients, preclinical and cellular models across different spatial and temporal scales of biological complexity using computational biology models and machine learning approaches (WP6). 6) To design new therapeutic interventions to reduce the penetrance of comorbidities in preclinical models (WP3 and WP4). This approach will help to improve diagnosis and understanding of prognostic factors, and will establish recommendations and targeted interventions to prevent or minimise comorbidities in persons with DS (WP7). Beyond the impact for patients with DS we expect that findings of this project will also be beneficial for patients in the general population.

Keywords: co and multimorbidities,mental disorders,obesity,stress,genetic,epigenetic,neglected population,intellectual disabilities
The logics of information visualisation (LOGIVIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Information visualisation is an essential tool in data-science, but the lack of a theoretical foundation currently prevents visualisation science to make substantial progress and develop solutions for the epistemological challenges posed by Big Data. Starting from the current state of the art in formal logic and the philosophy of information, the prospects of a new foundation for information visualisation are explored. This should lead to a model of the information-lifecycle in visualisation that sheds light on trade-offs in design decisions, gives a unified account for reasoning and communication with visualisations, and explains why and how information-visualisation allows us to climb the Data-Information-Knowledge hierarchy. Given the epistemic challenges in science and in policy-decisions, substantial attention is also devoted to what can go wrong with the use of information-visualisation, which requires the development of an account of mis- and disinformation, and of fallacious reasoning based on computer-generated representations of data.

Keywords: philosophy of information,visualisation,data science,internet studies,visual reasoning,visual communication
Innnovation capacity analysis and services for SMEs in Thuringia (INNCAS4TH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Germany
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 102500.0
EU funding (EUR): 102500.0
Participants: 2
Project status: CLOSED

Innovation capacity analysis and services for SMEs in Thuringia

Keywords: innovation capacity
eForcis and BeForcis, Wave Energy Generators for marine buoys and devices. (eForcis)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Maritime activities are essential to the European economy with an estimated gross value added of at least 260 bneuros and employ at least 6.6 million people. Exploitation of seas and oceans is increasing as new industries emerge and traditional ones move further off-shore. But while the marine energy sector is focusing on high potential energy, offshore activities need viable and cost-effective solutions to face their not very elevated energy demands. At the same time, the EU is seeking a balance between maritime industry growth and environmental damage reduction. Smalle has found a pioneering solution to this energy and ecologic challenge using an innovative approach. We are developing two reliable, autonomous and free of maintenance power supply systems -eForcis and BeForcis (eForcis adapted to the aquaculture sector)- that can obtain energy from less powered waves. By focusing on the generation of small amounts of energy through a simple off-grid mechanism, we will provide an alternative and satisfactory energy source for marine economic activities. This is especially relevant for key offshore sectors such as aquaculture and buoys (collecting data or creating signals for navigation security), as they will benefit from two ground-breaking power generators that will not only reduce carbon emissions but will also contribute to a more efficient and competitive sea industry in Europe and worldwide. Promising results gathered so far allow us to establish a twofold objective for this SME instrument phase 1: to analyze the techno-economic feasibility of the different eForcis equipment optimization routes and to explore the market potential of the current eForcis generator and its version for aquaculture (BeForcis). As a result, a marketing strategy will be developed to commercialize our products both through manufacturers/distributors (buoys and other devices) and end-users (aquaculture companies, oil and gas facilities, fish farms, Port authorities, among others).

Keywords: wave energy,buoys,aquaculture
System for AcceleroMeter-Based Assessment of cardiac FUNction (SAMBAfun)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Germany,Germany,Norway,Denmark
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2018)
Start date: 2018-12-01
End date: 2022-12-31
Duration (months): 49.0
Total project cost (EUR): 3688711.25
EU funding (EUR): 2918312.75
Participants: 6
Project status: SIGNED

In patients undergoing open-heart surgeries, perioperative cardiac monitoring is used to track the functioning of the heart and identify complications. However, myocardial failure and other severe complications can escape detection using current monitoring technologies, given the trade-offs between invasiveness, real time measurements, accessibility and accuracy of data. Given the high-risk profile of these surgeries, failure to timely detect complications leads to increased mortality and morbidity, which in turn results in increased hospitalization costs and lower quality of life for the affected patients. For effective cardiac monitoring, surgeons need real time data, 24h continuous monitoring during and post-surgery, and an accurate biosignal marker that can be trusted for immediate detection and assessment of cardiac events. No current technology enables this with low invasiveness and risk. Cardiaccs (SME) and Osypka (SME) will bring to market a patented solution that involves adding a 3-axis accelerometer to a standard epicardial pace lead, which is routinely used for most cardiac surgical patients, to assess cardiac motion and contractility in real time, both during and after surgery – and up to 7 days. Data from CardiSense will appear on a monitor and an alert function will let surgeons and nurses know as soon as a complication is picked-up on the continuously analysed data. SAMBAfun brings together 2 SMEs with complementary know-how, IPR and value chain positions. Cardiaccs patented the concept, whereas Osypka has 40 years of experience in developing cardiac pace leads. Osypka dominates the German market and has extensive ties to global distributors. Three leading research hospitals (Oslo, Aarhus and Berlin) will demonstrate the latest advances in this device, provide Key Opinion Leader input and contribute with multi-market, highly credible data for regulatory certification and health economic models to support reimbursement applications in all markets.

Keywords: heart contractility,heart function,accelerometer,early detection,open heart surgeries,critical care patients