Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
CHANGE. The development of the monetary economy of ancient Anatolia, c. 630-30 BC. (CHANGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Germany,United Kingdom,United Kingdom
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1981406.0
EU funding (EUR): 1490768.0
Participants: 3
Project status: SIGNED

This project gathers, for the first time, the evidence for the development of the monetary economy of Anatolia, from the invention of coinage there in the late 7th century BC to the absorption of the region by Rome c. 30 BC. Using new digital technology, it organizes this evidence to deploy it for the first time to answer major questions concerning the economic history of this region over the longue durée. Part 1 creates a complete overview of the relevant coinages produced by c.300 cities, 4 empires, 6 kingdoms, and c.50 independent dynasts in this period and region. Delivered with established Linked Open Data technology, this framework amalgamates coins in 5 public collections to create a database of c.50,000 coins. This database will be used to quantify monetary production over time and place. Part 2 assembles for the first time a full record of published finds of coins from hoard and excavation contexts. This data will be amalgamated with that from Part 1 to produce a detailed mapping of movement of coinage over time and place. Part 3 assembles a checklist of epigraphic documents attesting to monetary behaviour across the period of interest. This will be analysed for types and change of monetary activity over time, thus overlaying the evidence from one discipline on that of another. Part 4 comprises a series of interdisciplinary enquiries into the change in the monetary economy based on data from Parts 1-3. Major questions regarding the purpose of coinage, extent of monetisation, and efficiency of transaction will be investigated. It also addresses questions that have dominated recent debates such as economic connectivity, the existence of networks, and economic balance between large states and small. CHANGE will offer a case study of what can be achieved through the marriage of ‘traditional’ research with new methods and tools created by ‘Digital Humanities’. It offers a model for the re-evaluation of the monetary economy of the whole Ancient Mediterranean.

Keywords: ancient coinage,ancient monetary history,greek epigraphy,linked open data
The PIDDosome in Centrosome and Ploidy-Surveillance (POLICE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Austria
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 2355000.0
EU funding (EUR): 2355000.0
Participants: 1
Project status: SIGNED

Tight control of the number of chromosome sets in a cell (ploidy) is fundamental for normal development and organismal health. Most cells in our body are diploid, yet, some cells, including cardiomyocytes or hepatocytes require a balanced increase in ploidy for proper function. Polyploidization is accompanied by an accumulation of centrosomes, structures needed for nucleating the mitotic spindle and ciliogenesis. Extra centrosomes, however, promote aneuploidy in proliferating cells by causing errors in chromosome segregation, underlying a series of human pathologies, most notably cancer and premature ageing. How polyploidization is controlled in organogenesis and how errors in ploidy control contribute to disease is poorly understood. We recently demonstrated that the “PIDDosome” complex polices centrosome numbers in mammalian cells, alerting the tumor suppressor p53 in response to extra centrosomes. This is achieved by inactivating MDM2, the key-inhibitor of p53, by targeted proteolysis. MDM2-processing is mediated by caspase-2, a neglected member in a protease family that controls cell death and inflammation, activated in the PIDDosome. This exciting finding allows examining the consequences of deregulated ploidy and centrosome number in development and disease without interfering with p53, nor the cell fusion or cytokinesis machineries. This puts us in pole position to carry out an integrative study that aims to develop the PIDDosome as a new therapeutic target in cancer, related inflammation and in regenerative medicine. To meet this aim, we will define (i) the relevance of the PIDDosome in aneuploidy tolerance of cancer (ii) the role of the PIDDosome in controlling sterile inflammation and immunity (iii) the PIDDosome as a key-regulator of organ development and regeneration POLICE will open new lines of research at the interface of cell cycle, cell death & inflammation control and promote the PIDDosome as new target in our efforts to improve human health.

Keywords: caspases,ploidy,centrosomes,inflammation
Majorana bound states in Ge/SiGe heterostructures (MaGnum)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: CLOSED

Each particle has its antiparticle, and upon bringing them in close vicinity, they annihilate (they disappear). A fundamental question arises: what happens if a particle is its own antiparticle? Ettore Majorana predicted their existence and evidence has been put forward for the existence of such a state of matter in the form of quasiparticle excitations in hybrid semiconductor-superconductor devices. Research activites so far has concentrated on InAs nanowires, planar InAs and InSb nanowires. Theory suggests to look for Majorana bound states (MBS) in Germanium and I propose to use a novel yet promising material system, namely a Germanium/Silicon-Germanium heterostructure, to provide evidence for the topological state of matter leading to Majorana bound states (MBS). Using Ge/SiGe brings the advantage of a long mean free path, which will allow for a larger spatial separation of the MBS and facilitate the long anticipated but yet elusive detection of correlation of two MBS. Additionally, the planar geometry brings the possibility to couple the MBS to their environment, which will be important for their usage as topologically protected quantum bits for quantum computation. I propose to show step-by-step the ingredients necessary for a topological phase transition resulting in MBS. In particular, I will follow these steps: I will collaborate with G. Isella's group to develop a highly mobile two-dimensional hole gas and make it accessible for magneto-transport measurements. I will further confine the holes into a one-dimensional wire with tunable tunneling barriers at each end. I will test the presence of a strong spin-orbit interaction by measuring helical transport. I will induce superconducting order by coupling the wire to NbTiN contacts. Finally, I will test the presence of MBS with tunneling conductance measurements and use a proper geometry to show evidence of the correlation of two MBS at each end of the wire.

Keywords: semiconductor,sige heterostructure,quantum dot,quantum point contact,helical states,spin orbit interaction,majorana bound states,transport measurements
LEVERAGING LEADERSHIP FOR RESPONSIBLE RESEARCH AND INNOVATION IN TERRITORIES (RRI-LEADERS)

Framework: Horizon 2020 — Science with and for Society
Programme: Integrate society in science and innovation issues, policies and activities in order to integrate citizens' interests and values and to increase the quality, relevance, social acceptability and sustainability of research and innovation outcomes in various fields of activity from social innovation to areas such as biotechnology and nanotechnology
Action type: Coordination and support actions
Countries involved: Spain,Bulgaria,Greece,Switzerland,Denmark
Call: Supporting the development of territorial Responsible Research and Innovation (H2020-SwafS-2020-1, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 1994855.0
EU funding (EUR): 1994855.0
Participants: 9
Project status: SIGNED

RRI-LEADERS adopts a meso-level approach, and will explore the application and sustainability of the RRI paradigm within territorial innovation systems. In RRI-LEADERS a “territory” is understood as a confluence between three interconnected primary aspects: geographical location, socio-economic and cultural bonds, and administrative authority. The project will involve four distinct territories from different parts of Europe, representing different cultural and socio-economic backgrounds, different scope of territorial oversight, different institutional and decision-making infrastructures, different R&I landscapes, and different dynamics among territorial actors. As such, the four territories will represent a diverse range of opportunities and implications for RRI, which will enable the RRI-LEADERS consortium to carry out a thorough assessment of the RRI relevance to territorial governance and have the involved territories act as demonstrators for the potential of RRI on subnational level. The partners will engage in a multi-stage co-creation process (referred to as RRI-AIRR) that will mobilise territorial quadruple helix stakeholders towards the elaboration of future-oriented strategy and action plans - territorial outlooks for each of the participating territories. Territorial partners will have the leading role in this process, and will additionally work to ensure the broadest societal and governance-level endorsement. The Consortium will further use the accumulated knowledge to chart a detailed outlook for the future potential of RRI as a guiding framework in territorial governance of R&I, and will aim to provide an evolutionary perspective on RRI for the upcoming Horizon Europe programme.

Keywords: co creation,territorial governance,rri leadership,anticipation,inclusiveness,reflexivity and,responsiveness airr dimensions
Develop simple tissue regeneration technologies for the benefits of humanity by leveraging the biomimetic properties and the mechanical advantages of a new silk manufacturing nanotechnology. (SilkByPass)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Silk Biomaterials is a nanotechnology platform company. Its goal is to revolutionize the €85bn global tissue engineering market by leveraging the biomimetic properties and the mechanical advantages of silk. SilkByPass, a device designed for the regeneration of small blood vessels, will be the first product developed by Silk Biomaterials. About 560k/year coronary artery bypass graft surgeries (CABG) are performed in OECD countries. The current golden standard for CABG is autograft (mainly saphenous vein, umbilical vein and mammary artery) and very often more than one graft is required for each procedure. However, autografts are not always available and present several drawbacks: so, there is a global urgent need for man-made grafts. Very few synthetic grafts are on the market and, due to their very poor results, they are used only when autografts previously failed. There is also a need for man-made solutions for peripheral blood vessels, like saphenous veins and carotids. For those vessels there are no autografts available and small calibre synthetic grafts fail in restoring the bloodstream. Our innovative nanotechnology stimulates faster natural human tissue regeneration, with no rejection risks or use of drugs. In addition to that, it is cheaper than other synthetic grafts, allows for easy surgery and doesn’t produce any dangerous degradation product in the patient’s body. Key opinion leaders, clinicians, venture capitalists and medical device companies have already recognized its commercial potential, which is estimated to be around €3.9bn annually in OECD countries. The feasibility assessment to be undertaken in Phase 1 will help Silk Biomaterials further de-risk its technological/commercial viability and plan for a series of activities requiring Phase 2 funding (i.e.: clinical trials, reimbursement negotiations, distribution and licensing agreements, etc.) that will improve the investment readiness of our company and strengthen its long term sustainability.

Keywords: tissue engineering,silk nanotechnology,advanced manufacturing of silk grafts
“Biosensor for Effective Environmental Protection through the on-site, automated monitoring of a large set of chemical contaminants in Water.” (BEEP-WATER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The Drinking Water Treatment Industry is subject to a stringent legislation regarding contaminants in water. Quality of water intended for human consumption and its monitoring are regulated under the drinking water directive 98/83/CE. Pesticides and heavy metals must be monitored and tested regularly with maximum allowable concentration of 0.1 μg/l for individual pesticides and 0.5 μg/l for the total amount of pesticides. The directive 2013/39/EU concerning emerging contaminants to be controlled in the field of water policy establishes what contaminants are identified for priority action at Union Level. Most important for the Drinking Water Treatment Industry is the cost associated to contaminants detection: approximately €160millions are invested in pesticide water analysis in Europe. Currently, a pesticide analysis costs an average of €300 per sample since it requires specific staff and high technology equipments. We have developed a prototype of BEEP-WATER biosensor technology able to detect and quantify on site a wide range of chemical contaminants including pesticides, heavy metals and emerging contaminants in water saving the cost associated to current laboratory analysis. The objective of our current project is the industry adaptation and implementation in the Drinking Water Treatment Industry of BEEP – WATER early warning system as a real quick and inexpensive alternative to current contaminant analysis systems in water.

Keywords: water quality monitoring,biosensor
Solar Energy for Food Industry (SEFI)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Austria
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Solar Energy for Food Industry Proposal for the elaboration of a feasibility study, including a CPVT market study, for the application of concentrated PV-T solar energy and Large Thermal Storage (LTS) as support to the development of sustainable Food Security, through the construction of 2 CPVT demonstration plants in food-processing facilities in southern and northern Europe. Demonstration plants are planned to be built in northern Europe, in the Netherlands, and in southern Europe in Spain. Phase one will submit technical and financial solutions which shall pave the way for phase 2 submission of a final construction project for both demonstration plants. The innovative concept proposed is a Solar Concentration Hybrid Photovoltaio Thermal Cogeneration system using state of the art triple solar cells and a solar tracking device to capture the maximum possible solar energy with a parabolic trough linear concentration. The novelty presented in the project focusses on the food processing industry which is the largest manufacturing sector in the EU with 1,048 bilion € turnover and 4.2 milion employees busy throughout the European Union. Food processing is a major energy consuming manufacturing sector, which accounts for about 20% of the total EU fossil fuel consuption and the project has the ambition to contribute to the reduction of this resource consumption. The project will work with 4 participants spread over 3 EU countries. All technologies were patended last year. The project will move the novelty from TRL8 to TRL9.

Keywords: solar,cogeneration,energy,solar energy,solar cogeneration,food production process,beverage production process,demonstration plants
European Carbon Fibres and Pre-Impregnated Materials for Space Applications (SpaceCarbon)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Austria,Greece,Portugal,Portugal
Call: Technologies for European non-dependence and competitiveness (H2020-COMPET-2017, 2017)
Start date: 2018-01-01
End date: 2022-06-30
Duration (months): 54.0
Total project cost (EUR): 4922544.93
EU funding (EUR): 4922544.93
Participants: 6
Project status: CLOSED

SpaceCarbon aims to develop European-based carbon fibres (CF) and pre-impregnated materials for launchers and satellite applications, enabling a European supply chain that is capable to reduce the dependency of the European Space sector on this critical Space technology and, therefore, reducing the risk of stopping future Space programmes, due to supply restriction and shortage of these materials from non-European sources. SpaceCarbon is expected to create the capacity in Europe to produce specialty CF products, and related intermediate products, by promoting the development of industrial and research facilities in these products and contributing to improve Europe’s worldwide competitiveness in the field of high performance Carbon Fibre Reinforced Polymer (CFRP) structures. In SpaceCarbon, it is objective to develop the semi-industrial manufacturing process for Intermediate Modulus (IM) CF (starting at TRL 6 and aimed to achieve TRL 8), targeting mainly launcher applications, and to improve the properties of the previously obtained High Modulus (HM) CF (starting at TRL 4) aiming at reaching a modulus in the range of 440 to 540 GPa at TRL 6. These properties will allow to enter in the range of HM CF products that are used in satellite sub-system applications. Moreover, the prepregs manufacturing process will be developed at semi-industrial scale to make possible to provide such materials at short-term to European Space End-users and to develop new prepreg formulations at lab scale, in view of enhancing composites performance for future Space missions. New testing methods will be developed to support the development and qualification of such materials, according to Space environment requirements. Finally, the design, manufacturing and testing of launcher and satellite sub-component demonstrators will be performed with the developed SpaceCarbon materials to validate their possible use at short and mid-term for Spacecraft structures.

Keywords: carbon fibres,pre impregnated materials,composites,high modulus,intermediate modulus,launchers,satellites
Enhancing at an Early Stage the Investment Value Chain of Energy Efficiency Projects (Triple-A)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Italy,Germany,Spain,Greece,Greece,Lithuania,Bulgaria,Czechia,Netherlands
Call: Mainstreaming energy efficiency finance (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-09-01
End date: 2022-05-31
Duration (months): 33.0
Total project cost (EUR): 1486196.25
EU funding (EUR): 1486196.25
Participants: 12
Project status: CLOSED

Triple-A has a very practical result-oriented approach, seeking to answer three questions: - How to assess the financing instruments and risks an early stage? - How to agree on the Triple-A investments, based on selected key performance indicators? - How to assign the identified investment ideas with possible financing schemes? The Triple-A scheme is introduced, compromising three critical steps (answering each question), with the following main outputs: - Step 1 - Assess: Member States (MS) risk profiles and mitigation polices, including a Web based database, enabling national and sectoral comparability, market maturity identification, good practices experiences exchange, reducing thus uncertainty for investors. - Step 2 - Agree: Standardised Triple-A tools, efficient benchmarks, and guidelines, translated in consortium partners’ languages, accelerating and scaling up investments. - Step 3 - Assign: In-country demonstrations, replicability and overall exploitation, including recommendations on realistic and feasible investments in the national and sectoral context, as well as on short and medium term financing. The Triple-A case study countries were selected to promote diversity across a number of factors, including: a leading European economy (Germany), an innovation front-runner in energy (The Netherlands), a weak economy, went through one of the longest and most severe recessions (Greece), an economy with slow economic recovery (Italy), a diversified economy with a strategic geographical location having some of the largest European firms (Spain), a country that has experienced one of the fastest economic recoveries in Europe (Lithuania), a progressing country with a once sceptical stance towards low-carbon development (Czech Republic), and a country, recovering from a slow transition to a market economy, with growing regional strategic role and significant ambition towards EU processes (Republic of Bulgaria).

Keywords: investments,risk mitigation,standardised triple a tools,efficient benchmarks,knowledge web based database,stakeholder dialogue,capacity building,in country demonstrations,recommendations