Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Holistic Unified Certification Approach for Novel systems based on advanced automation (HUCAN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Italy,Netherlands,Germany
Call: Fundamental Science and Outreach for Capacity-on-demand and Dynamic Airspace (HORIZON-SESAR-2022-DES-ER-01, 2022)
Start date: 2023-09-01
End date: 2026-02-28
Duration (months): 30.0
Total project cost (EUR): 998900.0
EU funding (EUR): 998900.0
Participants: 6
Project status: SIGNED

The HUCAN project addresses legal and regulatory challenges of an ATM environment with higher levels of automation. Coherently with the SRIA, that advocates the need for new methodologies for validation and certification of advanced automation that ensure transparency, legal aspects, robustness and stability under all conditions and take full consideration for a future ATM environment built on multiple AI-algorithms system of systems with a human-centric approach, the HUCAN project proposes a novel approach for certification and approval of new ATM-related airborne and ground systems embedding higher levels of automation, including those based on AI and ML. The proposed approach is intended to support both the approval/certification and the design phases of such technologies, developing to this end two interconnected products: (1) a new holistic and unified certification method for highly automated systems, whose main target users are EASA, national aviation authorities, qualified entities, and ANSPs, and (2) a set of suitable design guidelines and associated toolkit for streamlining the development of automation and AI-powered technologies, targeted to manufacturers. For the design and development of such products the project will review the most prominent trends and challenges in automation and AI research and applications regarding ATM systems, also analysing possible approaches developed in other socio-technical and safety critical domains, and taking into account all possible impacts of higher levels of automation, including those on ATCOs licence and training. A parallel analysis of certification approaches, legal and regulatory features and critical issues of such technologies will be carried out. Case studies specifically focused on capacity on demand and dynamic airspace will feed and validate the theoretical research and the design of both the approval/certification approach and the guidelines for the design produced by the project.

Keywords: certification,automation,automated systems,atm,artificial intelligence,legal,regulation,licence,training,machine learning
Black hole spin and mass function in gaseous proto-clusters (ProtoBH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

Gravitational-wave (GW) Astronomy opened a new window to the Universe from its infant state to the present. The key physical systems which allow probing the Universe through these vast time and length scales are Black Holes (BH). Low metallicity clouds, composed primarily of atomic hydrogen, before and during the epoch of reionization, are a natural environment for BHs to be born and form Binary Black Holes (BBH) which can merge via GW emission. Stellar BHs, being the remnants of the death of very massive stars, are generated early when a huge gas reservoir is available for accretion. Mass segregation leads the BHs close to the center of the system and a dense BH-subcluster, supported by gravitational fluctuations, is formed. The low metallicity of the gas suppresses cooling, while turbulence of the gas and the BHs’ motion further favor quasi-spherical accretion, surpassing the Eddington limit. For sufficiently compact configurations, the BHs shall grow in mass before the gas is depleted by stellar evolution and formation feedback processes. This rapid mass growth through turbulent hot accretion shall leave a distinct spin signature on the BHs. The BBH that accrete gas quasi-spherically may harden if there is not significant angular momentum loss from the system. Furthermore, these are also ideal conditions for high-redshift Intermediate Mass Black Holes (IMBH) to form. We shall calculate the spin distribution of stellar BHs accreting gas in proto-clusters, calculate the BH mass function following such accretion events, investigate the evolution of separation in accreting BBH in low-metallicity hot turbulent gas, develop theoretical models for the evolution of a BH-subcluster inside proto-clusters and investigate the formation of IMBH. Finally, we shall develop methods for identifying the origin of GW observations, confront our results with LIGO-Virgo-KAGRA data, and investigate synergetically the implications for the GW mission LISA and the X-ray mission Athena.

Keywords: gravitational waves black holes binary black holes lisa ligo virgo kagra dwarf galaxies nuclear star clusters globular clusters
Brain Health in Menopausal Women (MenoBrain)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Norway,Netherlands,Sweden,France,Lithuania,Spain,Austria,Finland,Luxembourg
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-09-01
End date: 2029-08-31
Duration (months): 48.0
Total project cost (EUR): 4610865.34
EU funding (EUR): 4476069.0
Participants: 20
Project status: SIGNED

With the global population of menopausal women projected to reach 1.2 billion by 2030, menopause represents a critical yet understudied period in women's health. Hormonal changes during this transition pose significant risks to brain health, cognitive function, and emotional well-being, while increasing vulnerability to age-related diseases such as Alzheimer's disease. Despite its profound societal relevance, menopause-related brain changes remain poorly understood, with limited biomarkers and evidence-based interventions available. MenoBrain aims to fill this gap by training a new generation of 15 doctoral candidates to address the pressing challenges of menopause-related brain health. The DCs will work within a multidisciplinary and international network of 18 participants (11 beneficiaries and 7 partners) spanning neuroimaging, neuropsychology, endocrinology, microbiome research and bioinformatics. MenoBrain will employ cutting-edge methods including advanced neuroimaging (MRI, DTI, PET, EEG), host-microbiome modelling, and computational BrainAGE models. This integrated approach will explore how hormonal changes associated with menopause and interventions such as menopausal hormone therapy impact cognitive health, gut-brain communication, and aging trajectories. The programme combines scientific excellence with a robust training structure to equip MenoBrain doctoral candidates with expertise in interdisciplinary and intersectoral research, advanced technologies, and transferable skills. By leveraging state-of-the-art infrastructure, MenoBrain will discover biomarkers for early detection of cognitive dysfunction, improve therapeutic strategies, and advance personalized healthcare for menopausal women. MenoBrain not only addresses a critical gap in women's health research, but also aligns with the EU's agenda to promote healthy aging, gender-specific healthcare, and fostering innovative training for the next generation of leaders in science and industry.

Keywords: womans health,hormones,hormone replacement therapy,mood and mental dysfunction,cognition,microbiome,gut brain axis,brainage,animal model,prebiotics,metabolic modelling
Radiation-detected NMR: new dimension for Magnetic Resonance spectroscopy and imaging (RD-NMR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Switzerland
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-03-01
End date: 2024-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Nuclear magnetic resonance (NMR) is a powerful spectroscopic technique, used in various fields, including chemistry, biology and medicine. However, conventional NMR has one big limitation, namely very small sensitivity, due to a low level of polarisation of nuclear spins and inefficient signal detection by an induction signal in pick-up coils. My ERC Starting grant has explored the use of radiation-detected NMR (RD-NMR), in which very short-lived nuclei were used as novel NMR probes, bringing up to a billion-fold increase in NMR sensitivity. Such nuclei are produced at a radioactive-ion beam facility and are polarised on the fly, before being introduced into the sample. In this Proof of Concept project, I want to use the advantaged of RD-NMR and explore the prospect of turning it into a more easily accessible analytic tool. I aim to build a prototype of a modular insert for conventional NMR and MRI spectrometers that will allow in-situ polarisation of longer-lived nuclei that can be acquired commercially. The insert will include a sample, rf coil for spin excitation, beta-particle detectors, connections to introduce the hyperpolarising agent and the radiolabelled molecule that will be polarised in situ. The insert will be complemented by hardware and software needed for the data acquisition. During the project we will also explore the most suitable exploitation path, we will refine the end users and end market (including a workshop at CERN), and will investigate the patentability of the results. I will collaborate with researchers from University of Mainz, Knowledge Transfer specialists, and companies active in NMR and MRI.
Innovating Preparedness by Leveraging SYNERGIES and Enhancing Results of DRM Projects (SYNERGIES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Disaster-Resilient Society for Europe
Action type: Innovation actions
Countries involved: Italy,Norway,Ireland,Germany,Netherlands,Estonia,France,Malta
Call: Enhanced citizen preparedness in the event of a disaster or crisis-related emergency (HORIZON-CL3-2022-DRS-01, 2022)
Start date: 2023-12-01
End date: 2026-11-30
Duration (months): 36.0
Total project cost (EUR): 5603260.0
EU funding (EUR): 4997020.0
Participants: 17
Project status: SIGNED

The SYNERGY project intends to promote preparedness with the coherent and synergic involvement of the different actors of disaster management. These actors include first and second responders, citizens, communities, education systems, authorities and public administrations, business companies and practitioners. The project will concentrate on five needs identified for disaster preparedness: i) involvement of all relevant actors in building preparedness; ii) strengthening preparedness education and training; iii) communicating with citizens; iv) management of spontaneous volunteers; v) ensuring sustainability of solutions for preparedness. To address these needs SYNERGIES is leveraging the knowledge, experience, and results of five H2020 projects (ENGAGE, RESILOC, LINKS, IMPACT, BUILDERS), and one nationally funded project (Ready2Help). The results of these projects will be integrated with practitioners' best practices and experiences, revised, and improved, increasing their level of maturity. Targeted research, including social science expertise, will be dedicated to covering remaining gaps and supporting the integration work. Three Real Preparedness Cases will offer the opportunity to orient the project work, evaluate the progress and demonstrate the final results. These Preparedness Cases are real situations in which stakeholders intend to improve preparedness with a better involvement and empowerment of citizens. The SYNERGIES activities will last 36 months with a Consortium composed of 16 partners, representative of all the types of stakeholders in DRM, including research organizations, business companies, first and second responders, civil society organizations, and authorities.

Keywords: disaster preparedness culture management of spontaneous volunteers
Cutting-Edge Anion Exchange Membrane Electrolyzer for Sustainable Green Hydrogen Production: From Advanced Catalyst Synthesis to Innovative Membrane-Electrode Assembly Fabrication (H2-IMPACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-01
End date: 2028-02-29
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: SIGNED

H2-IMPACT seeks to transform anion exchange membrane water electrolysis (AEMWE) technology to enable sustainable large-scale green hydrogen production. The project addresses critical challenges, including the need for cost-effective, durable, and platinum group metal (PGM)-free electrocatalysts, as well as the stability of membrane-electrode assemblies (MEA). To overcome these issues, H2-IMPACT implements innovative catalyst synthesis methods that precisely regulate electronic structures, maximize active site density, and enhance ionic conductivity. This includes the creation of high-performance Ni-based catalysts doped with high-valent metals, confined within porous carbon supports for anode and cathode. The project also develops a groundbreaking ionomer-free MEA design with a strip-shaped hydroxyl ion conduction pathway to control local pH and enable in situ/operando analysis under real operating conditions. H2-IMPACT aims to deliver a cost-effective 5-cell AEMWE stack prototype (TRL4), targeting hydrogen production costs below €2.5/kg and a lifespan exceeding 5,000 hours. The project focuses on four core objectives: designing durable PGM-free electrocatalysts, fabricating stable ionomer-free MEA, developing high-performance AEMWE cells, and demonstrating a large-scale prototype integrated with solar energy. The project strategy combines advanced materials science and electrochemical techniques to optimize AEMWE performance. H2-IMPACT will significantly enhance my research profile by providing multidisciplinary training in hybrid catalyst synthesis, operando/in-situ techniques, and scientific communication. It will also expand my professional network in technologies, such as metal-air batteries for bifunctional air electrodes. Additionally, I will contribute my expertise in electrolyzers to the host institution. The outcomes of H2-IMPACT will support the EU's green hydrogen strategy, promote renewable energy integration, and create new economic opportunities.

Keywords: platinum group metal free electrocatalysts,water electrolysis,sustainable green hydrogen production,membrane electrode assembly,anion exchange membrane
Emission of marine microplastics by waves and wind: A key mechanism for global microplastic dispersal? (AIRSEA-PLASTIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-12-01
End date: 2026-11-30
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 3
Project status: SIGNED

In this project, I will focus on one of the most uncertain processes governing the worldwide spreading of plastic particles, the ocean-to-atmosphere emission of microplastics (MPs). I hypothesize that these marine emissions are significant at the global scale and contribute to dispersal of MPs to remote ocean regions and back to land. I propose an innovative and complementary approach to test this hypothesis based on three Training & Research Objectives (TROs) including Field Observation and MPs identification (TRO1): The goal is to collect and identify marine-atmospheric MPs from surface ocean and atmospheric marine boundary layer; I will be trained for field sampling and MPs identification methods. Experimentation (TRO2): The purpose will be parameterization of the water-to-air transfer of MPs via bubble bursting experiments; I will be trained in laboratory experiments on bubble bursting MP emission. Modeling (TRO3): I will be trained for numerical ocean-atmosphere modeling of MPs emitted via sea spray and their atmospheric fate. All these three TROs will be addressed at the host institute CNRS-GET in Toulouse, and at UGA and AMU (secondments). In general, this interdisciplinary approach combining field observations, experimental work and modeling will enlarge our knowledge of the fate and global dispersal of MPs, constituting a threat in themselves but also as potential chemical and biological contaminants carrier, and will thus contribute to the characterization of the human, animal and plant exposomes.

Keywords: microplastic nanoplastic transportation entrainment air sea atmospheric oceanic modeling,global emission dispersal marine microplastic atmospheric microplastic
(Re)constructing the liver, brick by brick (LegoLiver)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Belgium
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2499920.0
EU funding (EUR): 2499920.0
Participants: 1
Project status: SIGNED

Mammals display an abundant capacity for organ growth in the neonatal window but lose this capacity in adulthood. The adult liver maintains some regenerative capacity, but this remains far below the neonatal growth capacity. The adult liver can replenish up to 70% of its mass after surgical resection. However, resection of larger volumes induces liver failure, which causes death of one in three patients. For decades hepatologists have tried to pharmacologically augment hepatocyte proliferation to improve liver regeneration, yet all these attempts have failed. Our recent liver cell atlas revealed the modular architecture of the liver, with each module containing a dedicated macrophage and stromal cell. The primary hepatic module is composed of 4 cell types: hepatocytes, sinusoidal endothelial cells, stellate cells and Kupffer cells. We studied this 4-cell-circuit across seven species and found that throughout evolution these cells became so interdependent that they operate as one interconnected functional module. Stepping away from the conventional hepatocyte-centric view of liver regeneration, we propose a paradigm shift in which we hypothesize that the key to successful liver regeneration is to maintain the integrity of each liver module. Our preliminary data indicate that multiplication of neonatal cells happens synchronously, while adult generation is characterized by uncoupled multiplication of liver cells. We will track the multiplication of liver cells in space and time across different biological models, during the neonatal window and in adults upon surgery, to identify the mechanisms that underlie the synchronous multiplication of neonatal liver cells. We will develop high-throughput functional in vivo screens to manipulate the hepatic molecular circuits and identify pathways that can boost liver regeneration and maintain cellular functionality, with as ultimate goal to identify novel classes of therapeutic targets that can boost liver regeneration.

Keywords: neonatal liver growth,liver regeneration,kupffer cells,monocytes,endothelial cells,hepatocytes,stellate cells,spatial transcriptomics,epigenetics,cell cell circuits,systems biology,crispr screens
Scientific excellence in Nano-CATalysis at the Heyrovský Institute (NanoCAT)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Czechia,Austria,Germany
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 1375500.0
EU funding (EUR): 1375500.0
Participants: 3
Project status: SIGNED

The overall aim of the NanoCAT project is to boost scientific excellence in Nanocatalysis at J. Heyrovský Institute of Physical Chemistry (HIPC) by creating a consortium network with outstanding research institutions, University Ulm and Vienna University of Technology. The consortium benefits from and fully utilizes complementary competencies, both at the scientific and management level. The partner institutions participate in joint research projects in the progressive field of physical chemistry, namely Nanocatalysis, bringing together all expertise and approaches instrumental to achieving the scientific objectives, by uniquely combining nanocatalysis, synthesis, surface science, and electrochemistry, from experiment to theory. Collaboration with respected experts enhances the visibility of HIPC in the European context, builds further scientific links, and fosters the HIPC integration into European Research Area. Aselfstanding activity is the creation of a European office at HIPC. The project structure comprises scientific exchanges of research staff, empowering the performance of nanocatalysis science; scientific exchanges of early-stage researchers (ESRs) supporting equal opportunities and gender balance; organization of community-building events such as opening and concluding international conference in Nanocatalysis, reaching better visibility and increasing the profile of all partner institutions, as well as organizing summer schools, with ESRs presenting their scientific achievements and gaining additional communication and soft skills; dissemination and communication to target audience; and project management structure guaranteeing smooth project implementation. The project dedicates a specific attention to ESR from the coordinator institution, reflecting young researchers' needs and encouraging ambitious, challenging, and international collaborative spirit.

Keywords: scientific and administrative exchange,scientific event,international conference,summer school,physical chemistry,nanocatalysis,decomposition of methanol