Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Overcoming specific weaknesses in tendon biology to design advanced regenerative therapies (Achilles)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Germany,Ireland,Ireland,Portugal
Call: Twinning (H2020-WIDESPREAD-05-2017-Twinning, 2017)
Start date: 2018-10-01
End date: 2022-06-30
Duration (months): 45.0
Total project cost (EUR): 999626.25
EU funding (EUR): 999626.25
Participants: 5
Project status: CLOSED

The main goal of Achilles is to significantly strengthen the science and technology capacity of UMinho in biophysics, cell/molecular biology and genetics/gene therapy in order to achieve global scientific excellence and competitiveness for the translation of advanced therapies/ tendon tissue engineering strategies to treat tendon injuries/diseases; At the same tine, Achilles also aims at positioning the research profile of UMinho and its staff in an outstanding international research level. This will be achieved by establishing a twinning process through knowledge sharing and collaboration between 3B’s Research Group of University of Minho (UMinho) and 2 internationally leading institutions: Department of Trauma Surgery of the University Regensburg Medical Centre (UHREG) and the Regenerative, Modular & Developmental Engineering Laboratory of the National University of Ireland Galway (NUIG). Achilles will focus in defined areas in which UMinho shows a less scientific knowledge and are well-complemented by UHREG and NUIG. The project objectives are: - To significantly increase the scientific excellence in tendon tissue engineering and reinforce human resources profile of UMinho; - To significantly increase the international visibility of UMinho and unleash its networking gaps with international outstanding R&D organisations; - To create strong links between UMinho-UHREG-NUIG allowing a constant and sustained knowledge sharing and research collaboration network which will continue sustainably in the long-term; - To significantly increase the capacity of UMinho to translate excellent scientific production into new therapeutic approaches for the treatment of tendon disorders and in providing high-quality services and consulting, improved capability to compete for funding as well as generating useful intellectual property that can help to support in the long-term the sustainability of the organization.

Keywords: advanced therapies for tendon diseases,tendon tissue engineering,gene therapy,cell,molecular biology,biophysics,twinning,scientific excellence,international competitiveness
Development of fast antibody-based screening tests for the detection of harmful mycotoxins in food and feed (MycoTest)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

The contamination of food and feed with harmful fungal derived mycotoxins is a problem worldwide and worsening. Over 400 different mycotoxins are now known, some of them have been studied in great detail, while the data about toxicity and occurrence for many others are scarce. This information is required to determine the risk in relation to animal and human health and establish maximum permitted levels that do not pose any health concerns. The fast elimination of contaminated food and feed from the supply chain is crucial for the protection of human and animal health as many of these toxins can cause serious diseases both after acute and chronic exposure. The occurrence data cannot be provided without fast and reliable detection methods that allow quantification of these toxic contaminants. This research, therefore, is focused on delivering new fast antibody-based (ELISA) screening methods for the detection of three important mycotoxins: T-2/HT-2, ochratoxin A and sterigmatocystin and on the development of a first multiplex flow-through rapid (FTR) test for the simultaneous detection of mycotoxins in food and feed. These tests could be used by food and feed producers, importers and testing laboratories to assure food and feed safety on the European market. The researcher will work for two years with the food safety company EuroProxima (EP) in the Netherlands that will provide training and support of the development of the commercial analytical assays. The project will be also supported by the partner organisations - Institute for Global Food Security (IGFS) at Queen's University Belfast (QUB) and RIKILT Wageningen UR (RIKILT) who will be hosting secondment phases in order to facilitate the work packages. This project aims to combine academic excellence with specialist SME know-how to work on a project with significant impact on public health and that offers a substantial commercial opportunity.

Keywords: mycotoxins,detection of mycotoxins in food and feed,food safety,human health,immunoassays,elisa,flow through rapid assay
Ecological Modelling of the Greenland Ice Sheet Surface Ecosystem (EMoGrIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Czechia
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 142720.8
EU funding (EUR): 142720.8
Participants: 1
Project status: CLOSED

Glaciers and ice sheets contain distinct ecosystems and are very vulnerable to the ongoing climate change, with potentially significant impacts. However, predictions of future glacier ecosystem change are virtually impossible due to the lack of a theoretical framework of glacier and ice sheet ecosystems that would enable their mathematical modelling. The principal aims of the proposed fellowship are to provide a theoretical framework of the microbe-dominated supraglacial (glacier surface) ecosystem of the Greenland Ice Sheet and to develop a tool for prediction of the future change of the ecosystem, and to establish the Greenland Ice Sheet as a model ecosystem for studying microbial biogeography and diversity patterns. This will be achieved through developing a conceptual model of the system, its mathematical formulation, verification and validation, and subsequent simulations of future climatic scenarios. Furthermore, a sampling strategy will be developed allowing direct testing of relevant ecological hypotheses such as the diversity-productivity relationship. A two-way knowledge transfer is a key feature of this project: The Fellow will take advantage of the expertise of the Supervisor and the Department in ecological theory and modelling, while transferring his knowledge of glaciers as microbe-dominated ecosystems to the Department.

Keywords: glacier ecosystem,ecological modelling,microbial ecology,greenland ice sheet
Mapping Magnetic Fields with INterferometry Down to Event hoRizon Scales (M2FINDERS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-11-01
End date: 2026-10-31
Duration (months): 60.0
Total project cost (EUR): 2499995.0
EU funding (EUR): 2499995.0
Participants: 1
Project status: SIGNED

Active galactic nuclei (AGN) are the most extreme sources of radiative and kinetic power in the Universe, often outshining their entire host galaxies. The production and outward transport of the AGN power can be explained involving rotating supermassive black holes, accretion disks, relativistic plasma jets, and magnetic fields. These plasma jets have been imaged on scales from a few light-days up to thousands of light-years using Very Long Baseline Interferometry (VLBI). The Event Horizon Telescope Collaboration (EHT) has succeeded in imaging the putative super-massive black hole in the galaxy M87 on event horizon scales with sufficient sensitivity and resolution to confirm theoretical predictions derived from General Relativity. However, to ultimately establish the existence of such black holes and to determine their physical properties, precise information is needed about the magnetic field near the event horizon, where it reflects the fundamental black hole physics and governs the formation of the relativistic jets. Such measurements pose tremendous challenges and cannot be realised merely from improvements of the EHT imaging. M2FINDERS will meet this technical and astronomical challenge and precisely map magnetic fields at distances smaller than 1000 gravitational radii. To achieve this ambitious goal, I will combine multi-frequency polarimetric VLBI imaging and opacity measurements with novel methods for image analysis and modelling of relativistic flows. Leveraging the recent major advances in VLBI instrumentation, I will undertake an observational program that will result in the most stringent constraints on the strength and structure of the magnetic field near the event horizon. This will provide crucial independent evidence, complementary to EHT imaging, for the existence of black holes and their event horizons.

Keywords: active galactic nuclei,jets,magnetic fields,supermassive black holes,event horizon,relativistic,plasma
Inter-tissue communication during nematode infections: role of dermal γδ17 T cells (INTERCONNECTION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Complex multicellular organisms evolved to ensure that each tissue or organ responds appropriately to infectious challenge. Achieving pathogen elimination whilst preventing excessive collateral damage often requires the coordination of opposing types of immune responses (such as type-2 and type-17) within particular tissues. Reaching this equilibrium is even more complex when we consider pathogens that migrate across different organs. The mechanisms orchestrating immune responses between tissues, however, remain largely unexplored. Helminth infections provide great models to investigate this process as infective larvae migrate across different organs to complete their life cycles. In this proposal we will employ two distantly related nematode parasites, Nippostrongylus brasiliensis and Litomosoides sigmodontis, to identify and dissect the common mechanisms responsible for coordinating immune responses between different non-lymphoid tissues. Although exhibiting very distinct infection dynamics, both parasites induce host-protective type-2 immune responses, which are the result of an intricate cross-talk with type-17 immunity and poorly understood events early during infection. In addition, both nematodes have the skin as their entry site. Thus, we will employ state-of-the-art high-dimension techniques to generate an extensive phenotypical and topological characterization of the immune responses against nematode larvae in the skin. Moreover, a novel approach for local genetic manipulation of IL-17-producing dermal γδ T cells (the main orchestrators of skin type-17 immunity) will allow us to transpose the mechanisms of type-2/type-17 cross-talk to an inter-tissue dimension. Hence, by determining how skin immunity impacts the generation of systemic immune responses INTERCONNECTION will provide a new holistic view of nematode infections and open avenues of research that pave the way for immunization strategies of the future.

Keywords: nippostrongylus brasiliensis,litomosoides sigmodontis,t cells,il 17,type 2 immunity,inter tissue communication
Enabling an Open Innovation Model for EU Toy Industry SMEs through Co-Creation with FabLabs, Safety Experts and Customer Communities (ToyLabs)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Spain,Italy,Greece,Greece,Romania,Greece
Call: Support technology transfer to the creative industries (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2018-06-30
Duration (months): 18.0
Total project cost (EUR): 1223325.0
EU funding (EUR): 999825.0
Participants: 9
Project status: CLOSED

Toys market in EU (and globally) is characterized by the domination of a limited number of huge global brands, even though 99% of EU toy manufacturing companies are SMEs. Thus SMEs need to find new ways to strengthen their position, against large competitors. In this context, ToyLabs envisions to introduce a new model that will innovate on the value network of SMEs, towards the direction of changing their market positioning & prospects in the Toy Industry, overcoming obstacles like geographical barriers and fragmented markets. In particular, a multi-stakeholder co-creation network will be created, supported via an open ICT platform, that will bring together a toy manufacturer with other key players of the toy industry value network – FabLabs, Toy Security Experts and End Customers- to collaborate closely for the provision of new toys, that will be user-oriented, will respond to a clear market demand and will be probably addressed to multiple markets. Through ToyLabs approach, each involved stakeholder is expected to offer his valuable perspective that will open up new opportunities for SMEs. Taking advantage of the platform, a toy manufacturer will be able to collect multi-source feedback on new product concepts & designs, through iterative cycles where the initial idea is firstly co-designed with FabLabs, validated by toy safety experts and evaluated by prospective customers both virtually (via augmented reality technologies) and actually (based on prototypes). The main outcomes of the project will be the creation of the ToyLabs collaboration network, based on an innovative ICT enterprise collaboration platform, enriched with added value services utilising state-of-play emerging ICT technologies (e.g. social analytics, augmented reality) and a complete methodological approach to support the operation of the network in order to offer to any SME Toy Manufacturer the opportunity to initiate an alternative process for the creation of new, innovative products.

Keywords: additive manufacturing,3d printing,augmented reality,toys,games
Development of a Master Socket for optimised design of prosthetic socket for lower limb amputees (SocketMaster)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: A new generation of components and systems: Engineering of advanced embedded and energy and resource efficient components and systems
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Greece,Poland,United Kingdom,United Kingdom,Portugal,United Kingdom
Call: Smart System Integration (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2018-07-31
Duration (months): 42.0
Total project cost (EUR): 3950085.0
EU funding (EUR): 3950084.0
Participants: 10
Project status: CLOSED

The function of a lower limb prosthetic is highly dependent upon the characteristics and anatomical profile of the residual limb. This is unique to each individual and changes depending on the activities being engaged in by the amputee. A poorly fitting prosthetic socket can cause significant trauma so it is important to consider how to optimise the fit to maximise the amputee's comfort whilst wearing the limb prosthesis. Current practice in designing a prosthetic socket is time-consuming, and is highly dependent on the experience of the prosthetist. The SocketMaster project aims to integrate micro electronic, mechanical (pressure and acceleration), fluidic biomechanical and moisture sensors into a Master Socket which can help prosthetists to achieve fast customised design and manufacturing of prosthetic sockets for lower limb (trans-femoral and trans-tibial) amputees. Firstly, existing micro sensors such as piezoelectric, MEMS based pressure sensors will be adapted or developed so that pressure distributions within the interface between the residual limb and the socket can be measured. Secondly, a Master Socket will be built by assembling the sensor system in a rigid hosting socket in such a way that the sensors' positions can be adjusted to achieve a comfortable configuration for the patient. The pressure distributions at typical activities of a patient will be used to optimise the socket design to maximise the patient’s comfort. The digital 3D data of the optimised socket design can be fed into a rapid prototyping machine for fast fabrication. Thirdly, clinical trials will be carried out to validate the Master Socket. It is envisaged that SocketMaster will enable same day socket fabrication with optimised quality, and the fit and function of the prosthetic socket will be less dependent on the skills of the prosthetist.

Keywords: prosthetic socket,micro sensor,pressure,friction,moisture,temperature,master socket,socket design,sensor integration,clinical trial,biomechanical model
Regionalizing Infrastructures in Chinese History (Reginfra)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Belgium,Netherlands
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-04-01
End date: 2027-03-31
Duration (months): 60.0
Total project cost (EUR): 2499625.0
EU funding (EUR): 2499625.0
Participants: 2
Project status: SIGNED

RegInfra analyses how infrastructures such as city walls, roads, and bridges contributed to regional and empire-wide integration, and equally how they contributed to countervailing trends including local tensions, local autonomy, and cross-border regional formations in late imperial Chinese history (ca. 1000-1800). At a time when the People’s Republic of China is heavily investing in domestic and cross-continental infrastructures, we aim to map, compare, and critically analyse the material infrastructures on which Chinese polities of the past have been constructed. Key objectives include: • mapping the appearance and disappearance of large-scale infrastructures on an open access spatial analysis platform based on the digital annotation of the extant textual and archaeological record; • conducting comparative spatial analyses of the distribution of infrastructure features, their construction, maintenance, breakdown, uses and cultural meanings, and developing a regional history of infrastructures on this basis; • comparing data derived from the historical textual record and from modern archaeological reports and modelling processes of infrastructure development and decline; • publishing research in the fields of history, digital archaeology, and infrastructure studies that will substantially revise existing historiographies on the nature, durability, and efficacy of material infrastructures and contribute to emerging historiographies that place socio-economic and cultural developments in regional contexts and cross-border contact zones; • developing an event-based digital annotation method that will be made available for use in various languages; • developing a method for the automated extraction of data on infrastructure in Chinese archaeological reports including an ontology and a machine learning model Through these activities we aim to foster broader debate about the past and present uses and meanings of historical infrastructures and their digitization.

Keywords: chinese history,history of infrastructure,digital history,comparative history,digital archaeology
A preparative approach to geometric effects in innovative solar cell types based on a nanocylindrical structure (SOLACYLIN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 1938655.0
EU funding (EUR): 1938655.0
Participants: 1
Project status: CLOSED

The ERC Consolidator Grant project SOLACYLIN aims at providing experimental insight into the function of 'third-generation' photovoltaic systems by generating materials stacks structured in a well-defined, accurately tunable, nanocylindrical geometry. To this goal, we will develop and exploit advanced preparative methods based on two fundamental ingredients: (a) ordered 'anodic' porous oxides and (b) atomic layer deposition (ALD). The former solids will be generated as templates providing ordered arrays of straight, cyclindrical pores, the diameter and length of which can be varied between 20 nm and 300 nm and between 0.5 microns and 50 microns, respectively. The latter method will be used to coat the inner pore walls with one or several layers of the photovoltaic stack, each with a thickness set to values chosen between 1 nm and 30 nm. We will invent and characterize novel surface reaction schemes for the deposition in ALD mode (from the gas phase and from solutions) of functional materials (doped semiconductors and intrinsic light absorbers) with tailored chemical and physical properties. We will investigate the experimental conditions in which they can be combined in a way that optimizes the quality of their interfaces. Finally, we will quantify the electrical and photovoltaic performance of p-i-n junctions prepared with our methods. We will have the unique capability of describing in a systematic, accurate manner how the experimental photovoltaic parameters depend on the individual thicknesses of the individual layers and on the length of the cylinders. This direct experimental handle on the amount of light absorbed, on the one hand, and the charge carrier transport distances to the electrical contacts, on the other hand, will be correlated with the relevant material parameters (absorption coefficients, carrier mobilities). This information will unveil the phenomena limiting the efficiency of each type of solar cell, and suggest avenues to remedy them.