Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Global assessment of grapevine microbiome function to promote sustainable vineyard management (FUNVINE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-16
End date: 2025-01-15
Duration (months): 27.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: CLOSED

Vineyards are integral to supporting the ecology and economy for a sustainable society, as they cover a large portion of land worldwide, and represent an important source of income for local economies. The intensification of viticulture including the excessive use of plowing and agrochemicals has resulted in eroded and biologically impoverished vineyards with associated negative consequences for growers and the environment. Given these challenges, we must now work to restore sustainable biodiversity and ecosystem function while increasing the margin of benefits for growers. An important step in this process is to investigate the functional microbiome associated with grapevine roots and leaves because it controls key processes such as pathogenesis, symbiosis and nutrient cycling. To do so, a global collaborative research network has begun to identify the members of the grapevine microbiome (bacteria, fungi and micro-fauna); the proposed research project (FUNVINE) would complement microbial community analyses by simultaneously characterizing the microbial functional attributes of grapevines worldwide using advanced shotgun metagenomic approaches. FUNVINE will include two major research components to improve our knowledge to help achieve sustainability in vineyard management; 1) global-scale functional profiling of the grapevine microbiome, and 2) manipulative experimentation to identify the impacts of environmental change on grapevine-microbiome interactions. These research objectives will expand global knowledge of the microbial mechanisms that benefit or inhibit grapevines across environmental gradients, including under a major climate change-driven stressor -- drought. Overall, the FUNVINE project will reveal for the first time, the mechanisms of the grapevine microbiome across regions, environmental gradients, and grape varieties, thus providing answers to many of the greatest challenges to healthy, productive, and sustainable viticulture systems worldwide.

Keywords: metagenomics,sustainable agriculture,microbial mediation,viticulture
Computational imaging through scattering materials using speckle correlation (SpeckleCorr)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2125000.0
EU funding (EUR): 2125000.0
Participants: 1
Project status: SIGNED

When viewed under coherent imaging conditions (e.g. laser illumination), scattering materials such as biological tissues create noise-like images known as speckle. Despite their seemingly random nature, speckle patterns have strong statistical correlation properties that are highly informative of the material producing them. These can be used to enable remarkable imaging capabilities, not possible with current state of the art, for example seeing through highly scattering layers. Unfortunately, realizing these in practical settings (tissue imaging, fluorescence microscopy) remains a challenge. Research efforts are hindered by a lack of modeling tools, resulting in an incomplete understanding of speckle properties. This project aims to use computational techniques from computer vision and computer graphics to greatly enhance our understanding of speckle statistics, and significantly expand the scope of their applications. To this end, the project will explore algorithmic tools newly-developed by the PI that can accurately and efficiently simulate speckle patterns, to formulate better models of speckle formation. We will exploit our new understanding to develop new types of computational imaging systems that can directly measure speckle correlation, rather than the traditional pipeline where one captures speckle images and estimates their correlations algorithmically in post-processing. Finally, we will exploit these tools in multiple computational imaging applications, including: (i) Acquiring material parameters: estimating the type, size and density of particles composing a material of interest. (ii) Imaging fluorescent sources deep inside scattering tissue. (iii) Adaptive optics imaging. Potential impact is anticipated in numerous areas where speckle-based imaging techniques hold promise, including medicine (increased depth penetration of tissue imaging techniques) and material fabrication and analysis (accurate characterization of scattering materials).

Keywords: computational photography,scattering,memory effect
Systemic Effects on Metastasis - a look beyond the tumor (SYST-E-MET)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-05-01
End date: 2031-04-30
Duration (months): 60.0
Total project cost (EUR): 1499987.0
EU funding (EUR): 1499987.0
Participants: 1
Project status: SIGNED

What would you do if you were diagnosed with pancreatic cancer? The chance that it would happen is not that high (life-time risk of 1/60), but neither is the chance to survive (10%). In addition, the quality of life as a patient is severely compromised by inadequate understanding of the metastatic process, and lack of targeted treatment options or biomarkers to individualize treatment, leading to severe side-effects despite lack of treatment response in most cases. To make a difference and challenge this disease, by appreciating the systemic nature of cancer, I propose to focus on the role of the liver, the main organ of metastasis leading to subsequent death, in pancreatic cancer. I recently demonstrated the potential of using liver-derived information to predict outcomes in pancreatic cancer patients undergoing resection for localized disease (Bojmar et al., Nature Medicine, 2024). With this proposal, I suggest that the liver plays an active role in the progression of pancreatic cancer, and that this can be used to inform on treatment decisions, thereby improving the survival and quality of life in this patient group. I will investigate this concept through a translational study led by my team to evaluate treatment decisions guided by liver-based diagnostics, aiming at directing treatment locally or systemically, based on the metastatic biology of the cancer. Improving our knowledge about this stage of the disease could provide a treatment-window and open the door for tailoring chemo- and immuno-therapy, based on the systemic nature of the disease. I am uniquely positioned to lead this study, with my previous experience from the U.S., leading the first study of the human “pre-metastatic liver” in pancreatic cancer patients. Now independently established with my translational team and liver-based trials in the Swedish population, I aim to understand and tackle pancreatic cancer’s metastatic potential, thereby improving the life of afflicted patients.

Keywords: pancreatic cancer,metastasis
Urban B/ordering: An Ethnographic Study of the Ghetto Package in Denmark (UrBorder)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark,Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 2
Project status: CLOSED

At a time when migration is increasing, many EU countries still struggle with fully accepting migrants and other minorities. In this context, increasingly, member states introduce laws and regulations that police borders and reinforce social boundaries, and as a result, undermine the idea of liberal democracy. These practices, often labelled b/ordering, constitute attempts to control and order the ‘unknown’ or ‘undesired’ subjects. While much literature has dealt with this, it remains understudied how b/ordering works in and through urban planning and housing. The proposed project addresses this lacuna through an interdisciplinary analysis of such a practice of urban b/ordering: the Ghetto Package in Denmark, i.e. a set of laws implemented to break up migrant ‘parallel societies’ and enforce social mix. The proposed project further develops existing studies dealing with b/ordering by linking three scientific strands of literature: anthropological criminology, urban studies and migration. Methodologically, it will rely on participant observation, focus groups, life-histories, and semi-structured interviews in two different housing areas affected by the Ghetto Package in Denmark. This way, it will complement the existing analyses on the normative and discursive elements of b/ordering with an ethnographic account of its implementation and social and political consequences. Likewise, focusing on an iconic liberal democracy like Denmark will elicit knowledge on potential societal effects regarding citizenship and belonging in the EU. Academically, the project will benefit from the placement at the University of Copenhagen, the prominent research centre, the Centre for Global Criminology, and a Secondment at the inspiring research environment at the Amsterdam Institute for Social Sciences Research, University of Amsterdam.

Keywords: bordering borders boundaries spatialization and materialization of power
Graduate Research On Worldwide challenges (GROW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Netherlands
Call: MSCA COFUND 2022 (HORIZON-MSCA-2022-COFUND-01, 2022)
Start date: 2024-07-01
End date: 2029-06-30
Duration (months): 60.0
Total project cost (EUR): 6854400.0
EU funding (EUR): 6854400.0
Participants: 1
Project status: SIGNED

GROW – Graduate Research On Worldwide challenges – is an international PhD programme that offers tomorrow’s leaders a unique opportunity to do high quality and novel research with supervision from globally renowned professors on pressing issues affecting the people of Africa, and make a real contribution to understanding and addressing worldwide problems. Research and innovation that is interdisciplinary, international and intersectoral (Triple-I) stands a better chance of understanding wicked challenges and producing creative and effective solutions. Thus, they can play a vital role in meeting the 2030 Sustainable Development Goals. Currently the African continent has few R&D staff compared to other regions. With GROW we invest in training scholars with an understanding of the continent, while strengthening existing Africa – Netherlands partnerships. Because academic and non-academic stakeholders are involved from the start – collective learning and co-creation makes for deeper understanding of the challenges and their trade-offs, more detailed specs, earlier prototype testing, more opportunities for validation and transforming academic research results into real-world developments. As the science is complex and original, it can also be captured in high quality scientific papers. For GROW, 6 high ranking Dutch universities have joined up with 22 African academic and 16 non-academic partners so that 51 PhD students from anywhere in the world can pursue scientifically challenging research that in some way links LMICs in Africa with Europe. The possibilities are manifold, as fellowships are available in the Natural Sciences, Social Sciences & Humanities, and Engineering. The Triple-I design of the GROW programme offers the PhD students the chance to equip themselves with an advanced, future-proof set of scientific and complementary skills that they will take with them as they pursue high-flying careers in a world that is becoming ever more complex and interconnected.

Keywords: africa netherlands,interdisciplinary intersectoral international,global challenges,sdg trade offs,phd graduate training,cocreation intervention context research,ssh,engineering,natural sciences
Antimicrobial Stewardship, Prevention of Infection and Resistance in Africa (ASPIRE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Germany,Ethiopia,Ghana,Norway
Call: Tackling Antimicrobial Resistance (AMR) through R&D in novel and existing antimicrobials (HORIZON-JU-GH-EDCTP3-2024-01-two-stage, 2024)
Start date: 2025-04-01
End date: 2028-03-31
Duration (months): 36.0
Total project cost (EUR): 2840208.75
EU funding (EUR): 2840208.25
Participants: 8
Project status: SIGNED

African hospitals are increasingly providing microbiological diagnostics, hygiene and antimicrobial stewardship (AMS) procedures in response to multidrug-resistant (MDR) bacterial diseases. However implementation within integrated, multidisciplinary hospital services is often poorly established. We first aim to assess the impact of an enhanced hospital hygiene intervention on the incidence of healthcare-associated infections (HAI) in hospitalized patients, using a stepped-wedge cluster randomised trial (SW-CRT) design. Clusters (surgical, medical wards, ICUs) in four tertiary level hospitals in Ethiopia and Ghana will be transitioned to interventions focusing on hand and instrument hygiene procedures, hygiene procedures for visitors and standardized room surface cleaning. Microbiological assessments and AMR of patients and hospital environments will be conducted, with an expected 10-15% reduction in HAI incidence. Nested within the SW-CRT, we further focus on therapeutic drug monitoring (TDM) and predicted pharmacodynamic target attainment (PTA) to optimize beta-lactam antibiotic regimens as part of AMS procedures. Patients (N=400) with severe bacterial infections (e.g. sepsis) will receive standard versus standard plus TDM/PTA based AMS assessment, with dose optimization expected in up to 50% of cases. By integrating TDM/PTA into an AMS eHealth system, we aim to generate generalizable population-based PTA support, linked with cost-effectiveness analysis to promote sustainability within routine care procedures. By shifting antibiotic treatment from an empirical to a more individualized patient management strategy, we aim to introduce optimized and affordable AMS interventions, expecting an impact on improved clinical response and reduction of AMR within hospitals. Our study consortium is built on multidisciplinary expertise. Partners have been linked for years through African-European hospital partnerships implementing high quality microbiological diagnostics.

Keywords: antimicrobial stewardship,therapeutic drug monitoring,healthcare associated infections
Precision Gravitational Wave Astronomy with Black Hole Perturbation Theory (TestGravity)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-07
End date: 2027-10-06
Duration (months): 24.0
Total project cost (EUR): 252728.64
EU funding (EUR): 252728.64
Participants: 1
Project status: SIGNED

Since 2015, gravitational waves have entered the realm of astronomy, providing a new channel to observe our universe. The groundbreaking measurements of gravitational waves have extended our knowledge of gravity, black holes, and neutron stars. Like all measurements probing new, extreme regimes, gravitational wave astronomy has the potential to uncover new fundamental physics. Analysing gravitational wave signals requires accurate theoretical waveform models. Black hole perturbation theory (BHPT) has significantly contributed to waveform modelling and helped us understand the nature of black hole dynamics. The next generation of gravitational wave detectors will produce richer data requiring more precise models. The Laser Interferometer Space Antenna (LISA) mission was recently adopted by the European Space Agency and is planned to launch in 2035. Producing precise measurements of binaries and testing gravity are two key science goals for the LISA mission, but such measurements will require precision waveform models beyond our current capabilities. This proposal will advance waveform modelling to the required accuracy for future detectors by extending BHPT. I will extend BHPT models in General Relativity to second perturbative order for spinning black hole spacetimes—and create new models in alternative theories of gravity. The waveforms produced will help measure binaries and perform tests of gravity with LISA and ground-based detectors. UCD is the ideal sponsor for my fellowship because of its world-leading research group in BHPT. Combining my expertise in the theory of BHPT and alternative theories of gravity with UCD's expertise in practical BHPT waveform calculation will cultivate knowledge exchange and a successful project impact. An MSCA fellowship will result in my research testing our theory of gravity with gravitational wave astronomy.

Keywords: gravity,gravitational waves,black hole perturbation theory,general relativity,alternative theories of gravity,self force,quasi normal modes
Next-generation models and genetic therapies for rare neuromuscular diseases (MAGIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: France,Italy,Switzerland,United Kingdom,Germany,Ireland,Netherlands,Spain,United States,Portugal
Call: Development of new effective therapies for rare diseases (HORIZON-HLTH-2022-DISEASE-06-two-stage, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 6553472.0
EU funding (EUR): 6553472.0
Participants: 17
Project status: SIGNED

Muscular dystrophies are severe genetic disorders characterised by muscle wasting, impaired mobility and premature death, which to date remain incurable. Although preclinical and clinical evidence position genetic therapies amongst the key emerging treatments for several genetic conditions, no gene therapy or genome editing strategy has been approved for any muscular dystrophies yet. The lack of robust, human(ised) models enabling precise development of such advanced therapies is a major barrier towards their clinical translation for muscle diseases. To overcome this limitation, we have assembled the multidisciplinary MAGIC consortium to build novel, high-fidelity, models of human skeletal muscle pathophysiology which will be used to develop new vectors for safe and efficacious neuromuscular gene therapy and genome editing. Specific rare (paediatric) diseases targeted by our consortium are Duchenne muscular dystrophy (DMD), X-linked (XLCNM), autosomal dominant (ADCNM) and autosomal recessive (ARCNM) centronuclear myopathies (CNMs), LMNA- and COL6-related congenital muscular dystrophies (CMDs). Microfabrication, microfluidics and human stem cell differentiation technologies will be used to generate disease-specific human myofiber- and muscle-on-chip devices qualified for commercialisation, capable of screening toxicity and cell-specificity of new adeno-associated viral vector (AAV) capsid variants, and unique muscle-specific lentiviruses. Selected vectors will be equipped with novel lineage-specific regulatory elements to further restrict transgene expression to myofibres, muscle stem cells or interstitial fibroblasts, reducing also potential immunogenicity. The same vectors will be loaded with therapeutic genes or with new mutation-independent (for DMD and XLCNM) or mutation-specific (for LMNA- and COL6-CMD) gene editing tools, which will then be validated in dystrophic rodents. Finally, GMP-compatible batches of the top performing vectors will undergo advanced preclinical testing in large animals, preparing them for future clinical translation.

Keywords: neuromuscular diseases,skeletal muscle,bioengineering,gene editing,muscle stem cells
European Quantum Technologies Conference 2025 (EQTC2025)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Cluster 4 other
Destination: Other Digital, Industry and Space destinations
Action type: Coordination and support actions
Countries involved: Denmark
Call: Organisation of the Presidency Event European Quantum Technologies Conference (EQTC) 2025 (HORIZON-CL4-2025-QUANTUM-CONFERENCE-IBA, 2025)
Start date: 2025-06-12
End date: 2026-01-11
Duration (months): 7.0
Total project cost (EUR): 300000.0
EU funding (EUR): 300000.0
Participants: 1
Project status: SIGNED

EQTC2025 will serve as a platform to advance and promote Europe’s collective capacity within quantum research and technology. EQTC 2025 has three overarching goals. First, it seeks to deepen the connections within Europe’s quantum ecosystem by fostering collaboration among researchers, industry, and policymakers. Second, the event will serve as a global showcase of Europe’s academic excellence in quantum sciences as well as cutting-edge advancements in quantum technologies by presenting Europe’s progress to a global audience with an aim to position the continent as a leader in quantum research and application. Lastly, the conference will bridge the gap between research, industry, and policy by integrating activities that encourage cross-sector collaboration, ultimately driving the adoption of quantum technologies across diverse sectors.