Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Exponentially Improved Quantum memory (ExIQ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-15
End date: 2022-06-14
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

We plan to demonstrate a new approach towards quantum memories based on a theoretical proposal which is centered around the phenomenon of selective radiance. Selective radiance occurs when the distance between emitters around a waveguide is smaller than the wavelength of the emitters. In this case destructive interference suppresses light scattering into all modes except the forward propagating target mode. This drastically reduces photon losses and increases the efficiency of the quantum memory operation. The error rate of such a new type of quantum memory scales with the optical depth (OD) as exp(-OD) in contrast to the previously established 1/OD. We plan to implement this new scheme with atomic emitters coupled to a nanofiber. Nanofiber based atom-light interfaces are versatile and scalable platforms which allow to precisely study these fundamental quantum effects and at the same time allow for easy integration into fiber based applications. The effect of selective radiance depends upon a lattice with a period smaller than the emitter wavelength. This will be achieved through an appropriate new choice of the laser wavelengths used in the optical trapping scheme. For best memory performance all lattice sites need to be filled. To realize this we use a collisional blockade effect in a Lambda-enhanced gray molasses cooling which ejects one atom every time two or more atoms are present at a lattice site. To optimize the quantum memory performance we will perform an in-depth study of the phenomenon of selective radiance by analyzing the transmission spectrum, the scattering into free space and by ring-down measurements. In the last step we will demonstrate the quantum memory performance and the exponential scaling with OD. The successful demonstration of this type of quantum memory is an important steps towards large distance distribution of quantum information and paves the way for future quantum networks.

Keywords: nanofiber,collective effects
ERACoSysMed - Collaboration on systems medicine funding to promote the implementation of systems biology approaches in clinical research and medical practice (ERACoSysMed)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: ERA-NET Cofund
Partnership: ERACoSysMed (ERA-NET)
Countries involved: Austria,Germany,Ireland,Italy,Israel,Spain,Germany,Norway,Slovenia,Belgium,Slovakia,France,Netherlands,Luxembourg
Call: ERA-NET: Systems medicine to address clinical needs (H2020-HCO-2014, 2014)
Start date: 2015-01-01
End date: 2020-06-30
Duration (months): 66.0
Total project cost (EUR): 14778271.0
EU funding (EUR): 4876821.0
Participants: 15
Project status: CLOSED

Systems medicine is a new approach which integrates biological and medical data with mathematical and computational modelling in order to understand the underlying mechanisms of disease and to develop new strategies for individualised diagnosis, treatment and prevention. Systems medicine can fill the gap between experimental data produced by modern technologies and medical knowledge. Through the implementation of systems biology approaches in both clinical research and medical practice systems medicine will provide a new tool to clinicians that will change the capabilities of the clinician to diagnose and treat patients faster, better and more effectively – a tool, which has the potential to become a generic prerequisite for any personalized or P4 medicine approach. The central idea of ERACoSysMed is to implement systems biology approaches in medical concepts, research and practice by structuring, coordinating and integrating national efforts and investments during its project duration of five years. To achive this main goal the specific objectives of ERACoSysMed are: 1) Strengthen the systems medicine community both across national borders as well as across specific research areas 2) Establish a network of funding bodies to sustainably implement systems medicine across Europe 3) Launch joint trans-national research calls with the aim to push forward the desired paradigm shift towards P4 medicine 4) Provide a platform for the implementation of the actions recommended by the CASyM road map For this aim Joint transnational calls (JTCs) for research proposals will be implemented. As a first step a co-funded JTC call will be launched with the aim to select transnational research projects in a competitive approach that shall demonstrate the social and economic benefit of the systems medicine approach. The consortium intends to implement further JTCs and other networking activities in order to keep alive the momentum which will be created by the co-funded JTC.

Keywords: era net systems medicine,joint transnational calls,additional activities
Software Workbench for Interactive, Time Critical and Highly self-adaptive cloud applications (SWITCH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Spain,Slovenia,Romania,Netherlands,United Kingdom,Portugal
Call: Tools and Methods for Software Development (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 2922500.0
EU funding (EUR): 2922500.0
Participants: 6
Project status: CLOSED

The SWITCH project (Software Workbench for Interactive, Time Critical and Highly self-adaptive Cloud applications) addresses the urgent industrial need for developing and executing time critical applications in Clouds. Time critical applications such as disaster early warning, collaborative communication and live event broadcasting can only realise their expected business value when they meet critical requirements for performance and user experience. The very high requirements on network and computing services, particularly for well-tuned software architecture with sophisticated data communication optimisation, mean that development of such time critical applications is often customised to dedicated infrastructure, and system performance is difficult to maintain when infrastructure changes. This fatal weakness in the existing architecture and software tools yields very high development cost, and makes it difficult fully to utilize the virtualised, programmable services provided by networked Clouds to improve system productivity. SWITCH aims at improving the existing development and execution model of time critical applications by introducing a novel conceptual model (application-infrastructure co-programming and control model), in which application QoS/QoE, together with the programmability and controllability of the Cloud environments, can all be included in the complete lifecycle of applications. Based on this conceptual model, SWITCH provides an interactive environment for developing applications and controlling their execution, a real-time infrastructure planner for deploying applications in Clouds, and an autonomous system adaptation platform for monitoring and adapting system behaviour. The SWITCH consortium has well-balanced partners with complementary expertise from both academic and industrial backgrounds. By demonstrating the software using diverse use cases, the consortium specifically aims at exploitation of the business potential of the SWITCH results.

Keywords: time critical cloud applications,self adaptable system,software defined networking
Driving simulator for disabled people with scientific assessment of driving skills and indication to of adaptation to be made to the vehicle (DRIVING RIG)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Italy
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

This project involves the creation of a driving simulator for disabled people that can provide a scientific assessment of their driving skills and indicate the type of adaptation to be made to the vehicle. The product consists of three different components: a complex hardware device that assesses the driving context through sophisticated sensors, software that simulates various driving situations (sudden braking, queues, roundabouts, etc/) and a real-time analytics system that converts the series of measurements into a genuine medical/scientific assessment.

Keywords: disabled people
Assistant for Quality Check during Construction Execution Processes for Energy-efficienT buildings (ACCEPT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies enabling energy-efficient systems and energy-efficient buildings with a low environmental impact
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Germany,Italy,Germany,Spain,Germany,Cyprus,Belgium,Belgium,Netherlands,United Kingdom
Call: Development of new self-inspection techniques and quality check methodologies for efficient construction processes (H2020-EeB-2014, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 4463367.5
EU funding (EUR): 4463367.5
Participants: 16
Project status: CLOSED

Assistant for Quality Check during Construction Execution Processes for Energy-efficienT buildings Problem: What the consortium sees as a major problem today is the potential loss of benefits of energy-efficient building components because of the lack of knowledge or bad implementation during the construction processes. Solution: During the project ACCEPT will be created – An assistant for quality check during construction execution processes for energy-efficienT buildings. The assistant will run on Smart Glasses and unobtrusively guide workers during the construction on site. This provides a standardized and coordinated process for all workers, ensuring that all benefits of energy-efficient building components are maintained. From a user perspective ACCEPT is focused on the following very clear main results: 1. The Construction Operator Assistant App (CoOpApp) running on Smart Glasses, which passively collects data and actively provides guidance to the worker on site during the building process. (Pillar I: Advanced Knowledge Transfer for Energy-efficient Construction) 2. A Site Manager App (SiMaApp) running on a mobile device, which allows to remotely coordinate the working process as well as collect additional data on site by different sensors. (Pillar II: Agile Project Coordination for Bridging Heterogeneity) 3. An interactive web-based Dashboard as a monitoring and quality assurance solution. The Dashboard will use self-inspection methods to determine important characteristics such as U-Values. (Pillar III: Adaptive Quality Assurance with Self-Inspection Features) The project is fully build around achieving a maximum of impaxt: The three results will be accompanied by 7 real-world pilots grouped into 3 piloting areas within the project. Pilots are located in 4 different EU countries.

Keywords: assistant quality check construction execution processes energy efficient buildings development smart glass optical head mounted display natural user interface usability accessibility statement
Open Schools for Open Societies (OSOS)

Framework: Horizon 2020 — Science with and for Society
Programme: Encourage citizens to engage in science through formal and informal science education, and promote the diffusion of science-based activities, namely in science centres and through other appropriate channels
Action type: Coordination and support actions
Countries involved: Germany,Spain,Ireland,Australia,Israel,Italy,Greece,Finland,Bulgaria,Greece,France,France,Netherlands,Netherlands,Portugal,Luxembourg
Call: Open Schooling and collaboration on science education (H2020-SwafS-2016-1, 2016)
Start date: 2017-04-01
End date: 2020-03-31
Duration (months): 36.0
Total project cost (EUR): 3042250.0
EU funding (EUR): 2982250.0
Participants: 19
Project status: CLOSED

Our schools should be incubators of exploration and invention. They should be accelerators of innovation. They should promote Open Schooling. School leaders should set a vision for creating learning experiences that provide the right tools and supports for all learners to thrive. Teachers should be collaborators in learning, seeking new knowledge and constantly acquiring new skills alongside their students. A holistic approach to innovation is needed. We need to facilitate the process with a provision of the necessary catalyst: This is the foreseen role of the OSOS Coordination Action, to describe and implement at scale a process that will facilitate the transformation of schools to innovative ecosystems, acting as shared sites of science learning for which leaders, teachers, students and the local community share responsibility, over which they share authority, and from which they all benefit through the increase of their communities’ science capital and the development of responsible citizenship. In this framework the proposed coordination action is aiming to support a large number of European schools to implement Open Schooling approaches by a) developing a model that promote such a culture, b) offering guidelines and advice on issues such as staff development, redesigning time, and partnerships with relevant organisations (local industries, research organisations, parents associations and policy makers), and c) suggesting a range of possible implementation processes from small-scale prototypes through to setting up an “open school within a school” or even designing a new school while it is testing and assessing them in more than 1,000 school environments in 12 European countries. The themes of the project activities developed and pursuit in participating schools that will take place will focus on areas of science linked with the Grand Societal Challenges as shaped by the EC, will be related to RRI and will link with regional and local issues of interest.

Keywords: open schools,science capital,science education and careers,responsible citizen
Super-resolution imaging to uncover microRNA control of astrocytes in epilepsy (AstroMiRimage)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-12-01
End date: 2020-11-30
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

This Horizon2020 – Marie Sklodowska Curie Actions – Individual Fellowship grant proposal focuses on exploring mechanisms controlling the structure of support cells (astrocytes) in the brain that promote hyper-excitable neuronal networks and underlie common, chronic neurologic disorders such as epilepsy. My research builds on emerging data showing the molecular machinery for microRNAs - short non-coding RNAs that regulate gene expression post-transcriptionally by targeting mRNAs - is present locally, within astrocyte processes. For this purpose, I will employ for the first time super-resolution microscopy to visualise astrocyte processes and microRNAs in rodent and human brain. I will then target candidate microRNAs to influence astrocyte morphology, and increase local translation of neurotransmitter and ion channels in astrocytic processes. In turn, this allows the clearing of excess glutamate and potassium from the synaptic cleft and hence prevents synchronous neuronal discharges that generate seizures. During the fellowship, I will acquire new research skills in modelling epilepsy and through training and secondments, where I will visualise locally produced proteins in astrocyte processes after microRNA targeting. The ground-breaking nature of the project will enhance my creative and innovative potential. With advanced training and international mobility, the fellowship will help me to diversify my scientific and non-scientific skills needed to help me reach my career goal of transitioning into an independent principal investigator in molecular imaging and translational neuroscience focused on astrocyte biology and pathophysiology. These findings will have strong therapeutic relevance, offering a novel strategy for seizure-suppressive or disease-modifying actions via targeting microRNAs that regulate aberrant astrocyte morphology that could benefit patients with drug-resistant, refractory epilepsy, which affects approximately 2 million people in Europe.

Keywords: epilepsy,epileptogenesis,microrna,antagomir,astrocytes,super resolution microscopy,calcium imaging
Commercialization of novel Diagnostic Platform with Synaptic adaptation Arc treatment method for tinnitus patients. (Tinnitus Platform)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Poland
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Meeting demand for the first medical device for diagnosis and therapy of tinnitus is set to be a crucial challenge for future audiology and neurology. For that reason Kinetic Center of Advanced Audiology (www.kinetic-cna.pl/) aims to commercialize technologies for the Tinnitus examination and treatment. To do so, co-founders rely on their extensive experience and the interdisciplinary team of: audiologists, laryngologists, medical technicians, neurobiologists, neuroscientists, musical trainers, hearing care professionals, clinicians and nutritionists. Our main objective today is to bring to the global market a novel “Tinnitus Diagnostic Platform” which is a IT platform of multiple test, that can give more information and indicate with more precision the nature of the tinnitus and “Synaptic adaptation Arc therapy” which is dedicated for tinnitus patients after sudden hearing loss. We have conducted preliminary research studies on a small group of around 200 patients and the promising results encouraged us to demonstrate clinical effectiveness of our solution on n a bigger number of subjects. The key market application of Tinnitus Diagnostic Platform is to differentiate the pathology of hearing and finally to select appropriate treatment. Synaptic adaptation Arc therapy is based on continuous acoustic stimulation which enforces activity of hear cells and nervous system and gives opportunity to release Arc/Arg 3.1 protein that rebuild synapses. The project addresses the problem of lack of medical device for tinnitus diagnosis and very poor research on the course of the condition. Finally, to fully exploit and to commercialize this new and EU-based technology, we want to open new Advanced Audiology Clinics around Europe to propose complex methods on hearing pathologies. The Future growth will be driven through sales of Tinnitus Diagnostic Platform to other Audiology Clinics (B2B) and sales of Synaptic adaptation Arc therapy treatment set to patients (B2C).

Keywords: hearing disorder,ear disease,tinnitus,audiology,hearing and auditory pathway pathologies,diagnostic platform,hearing loss
SUGARSmart: Smart design of recombinant antibody fragments specific for carbohydrate molecules (SUGARSmart)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-07-10
End date: 2020-08-09
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

The development of new approaches to explore the diverse role of glycans in normal and physio- pathological conditions of the cell is a major challenge. Our previous research recognized roles of anti-glycan recognition molecules (lectins and antibodies) in the diagnosis of diseases like cancer, immunity, and hyperacute rejection upon bioprosthetic transplantation etc. However, because of the structural complexity, well-established approaches for developing glycan-based therapeutics are limited. To address this issues, SUGARSmart aims to develop a workflow for rational design of single-chain fragment variable (scFv) antibodies to enhance glycan recognition capabilities, both specificity- and affinity-wise (improving detection limits of assays). Three major aims will be pursued: First, we will apply molecular modeling to predict mutations which lead to enhance affinity and specificity of anti-αGal scFv. A range of mutational strategies will be tested in order to learn which scFv domains, which particular locations (functionally important sites), and which mutations (aromatic or polar) are best suited to improve affinity and specificity. Second, computationally predicted mutants will be obtained by mutagenesis or chain shuffling. Validity of the predictions will be tested by affinity-measurement (ITC/SPR), array techniques and ELISA. At the end, validation of computational models of scFv-glycan interactions with experimental techniques will enable us to propose a workflow to engineer other anti-glycan scFv antibodies. Overall, this project proposes an interdisciplinary approach to enhance our ability to quantify and engineer glycan recognition molecules having potential application in the smart and tailored development of future diagnostic reagents and therapeutics. To the best of our knowledge this will be the first attempt to provide a complete and coherent framework for anti-glycan antibody engineering, combining a wide computational pipeline and experiments.

Keywords: glycans,antibody,rational design,antibody engineering,carbohydrate recognition agent,scfv,modeling antibody glycan interactions