Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sequence sPecific ELImination of shiga-Toxin E. Coli (SPELITEC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-04-01
End date: 2022-03-31
Duration (months): 36.0
Total project cost (EUR): 3948250.0
EU funding (EUR): 2763775.0
Participants: 1
Project status: CLOSED

SPELITEC is the first treatment for Shiga toxin-producing E. coli (STEC) infections, which affects primary young children and can be fatal in 1-5% of the cases. Currently there is no validated safe treatment: hospitalized patients receive only symptomatic treatments consisting of rehydration coupled with transfusions and dialysis for haemolytic uremic complications. The SPELITEC program is designed to finalise preclinical and initiate clinical studies for elimination of STEC bacteria (Shiga-toxin producing E. coli) in paediatric populations with a dedicated product: EB003. EB003 selectively eliminates STEC bacteria early in the disease progression; it is not expected to exert any toxicity in humans or animals; it is a multivalent mix of different capsid variants allows to target the whole spectrum of clinically relevant strains and pre-empts the acquisition of resistance through mutation of bacterial receptors; it is administered orally by a liquid/gel which is patient-friendly and adapted to young children and it represents a cost-effective alternative to antibodies against Shiga toxins. Our technology is the only one allowing the specific elimination of STECs without toxin release and without disrupting microbiota and inducing antibiotic resistance. Eligo will complete early drug development, which should ensure market authorization given the orphan and unmet medical need nature of the indication, and plans to out-license the compound to an established pharma company that will launch the product on the market. The management team of Eligo has solid business and technical management experience in multinational companies and a very strong drug development background. During the Phase 2 project we will validate this new individualised therapeutic approach and mechanism of action by conducting the validation of the pharmacological model, the production of a clinical batch and the safety tests in healthy animals.

Keywords: selective bacteria elimination,microbiome,genomic sequence,stec
Algebraic K-theory -- Arithmetic and Topology (K-theory)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: CLOSED

Algebraic $K$-theory -- Arithmetic and Topology. The goal of the proposed project is to use recent results in algebraic K-theory to further the connection between algebraic K-theory on the one hand, and arithmetic and topology on the other. This will split the proposed project into two parts: The one exhibiting connections to topology, more precisely the topology of manifolds and Poincaré duality spaces, and the other exhibiting connections to arithmetic geometry, more precisely gaining access at explicit calculations of K-theory groups of (spectral) schemes. Both main goals build on previous work in which I played a role, on the one hand establishing the foundations of a new ``real algebraic K-theory spectrum'' which leads in particular to a solution of a conjecture of Hesselholt--Madsen, and on the other hand a recent result in algebraic K-theory which proves the existence of a ring spectrum, the circle-dot ring, which determines the failure of excision in K-theory. The pure existence (and some formal properties) of this ring have already been exploited for many applications, and the goal of this part of the project is to make the circle-dot ring more explicit and use this new knowledge for explicit computations.
Science promotion in Bistita-Nasaud county (Science4future)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Romania,Romania
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-07-01
End date: 2020-12-31
Duration (months): 6.0
Total project cost (EUR): 36500.0
EU funding (EUR): 36500.0
Participants: 3
Project status: CLOSED

Science plays a major role in the development of a society. Despite this, the general population of Romania has little knowledge about the impact of research on all aspects of life. In this context, events that advertise science among the general public are very welcome. Another strong argument in favour of organising the science popularization event in Bistrița is that this kind of events usually take place in major cities, while in small and medium towns they are very rare, so their population is missing the opportunity to discover science from a different perspective; in turn, this lack of information facilitates the occurrence of stereotypes about scientists and their work and about the usefulness of scientific research, which ultimately discourages young people to pursue a career in R&D. The main concept proposed for 2020 is to reduce the passive presentation of what means to be a researcher, by involving the people directly in different interactive activities (workshops, games, competition, debates etc.). The project is constructed around three basic ideas: Future through past; Health and wealth through a clean environment; Economic development of the county through technology and innovation. An important objective is also the future utilization of information gathered during the event, in order to enable cooperation between relevant actors that are committed to support scientific collaboration that may generate new opportunities for research and industry and new knowledge and know-how that can be shared by confronting new ideas and viewpoints. Regarding the audience, the Dissemination Strategy will be directed towards various user groups, such as: the general public, especially young people, the scientific community, public institutions, NGOs, policy-makers, various associations, businesses etc. The partners have the complementary skills to assure the achievement of the project objectives and the future exploitation of the results.

Keywords: research,science,innovation,carrier,impact,progress,future,pleople
Structure-based subwavelength imaging (SBSI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2015-11-01
End date: 2017-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Until recently it was believed to be impossible to perform optical imaging with resolution beyond the fundamental resolution limit. However, in the past few years, our team was able to algorithmically enhance the resolution of optical imaging, bringing it to below one fifth of the optical wavelength. This achievement is based on the prior knowledge that the image is “sparse”, that is, the image can be represented in a compact form in an appropriate mathematical basis. The purpose of this PoC is to develop an algorithmic platform – a software demonstration prototype - that would lead to commercialization of two (closely connected) applications: (1) Improving the resolution of Scanning Electron Microscope (SEM), used in the micro-chip industry for defects detection; (2) Improving high-resolution florescent microscopy (STORM) by reducing the number of exposures (iterations) required.
Investigating the functional architecture of microbial genomes with synthetic approaches (SynarchiC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: France
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2024-03-31
Duration (months): 72.0
Total project cost (EUR): 1995557.0
EU funding (EUR): 1995557.0
Participants: 1
Project status: SIGNED

The folding of eukaryotic and prokaryotic chromosomes consists of an assortment of intertwined structural features. The resulting complex networks of contacts is highly dynamic and interacts functionally with, or regulates metabolic processes ranging from gene expression to chromosome segregation. Some higher order structures involve evolutionary conserved molecular players, such as structural maintenance of chromosomes (SMC) proteins, while others depend on phylum specific proteins. The functional organization of yeast and bacteria chromosomes are actively investigated, with multiple folded structures uncovered in recent years. However, disambiguating the intermingled structures is a difficult task, limiting their functional characterization. In addition, current technologies are limited and are unable to track the genome-wide folding of duplicated sister chromatids (SC) molecules, limiting the study of genome folding during replication and mitosis. The overall aim of the SynarchiC project is to characterize, through innovative derivatives of the chromosome conformation capture technology combined with synthetic chromosomes, the folding patterns of microbial genomes during the entire cell cycle, including those of SCs. By reverse engineering chromosomes in bacteria and yeast, we will discriminate the different layers of topological structures and their associated molecular players. We will then investigate how these 3D structures affect SC folding, individualization, and segregation. Finally, we will investigate the interplay between a pathogen and its hosts during an infectious process. How the bacteria redirects its host chromosome metabolism in stressful environment will be addressed from the perspective of genome organization and segregation. Technologies and results from SynarchiC will provide fundamental insights on the cell cycle, and should appeal broadly to scientists working on various aspects genome functional organization in any clade.

Keywords: chromosome organization,chromosome segregation
Tax Evasion in Developing Countries. The Role of Firm Networks (DEVTAXNET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 1288125.0
EU funding (EUR): 1288125.0
Participants: 1
Project status: CLOSED

Tax evasion leads to billions of Euros of losses in government revenue around the world. This does not only affect public budgets, but can also create large distortions between activities that are fully taxed and others that escape taxation through evasion. These issues are particularly severe in developing countries, where evasion is especially high and governments struggle to raise funds for basic services and infrastructure, while at the same time trying to grow independent of international aid. It is widely suspected that some of the most common and difficult to detect forms of evasion involve interactions across firm networks. However, due to severe data limitations, the existing literature has mostly considered taxpayers as isolated units. Empirical evidence on tax compliance in firm networks is extremely sparse. This proposal describes 3 Sub-Projects to fill this gap. They are made possible thanks to access I have obtained -through five years of prior research and policy engagement– to unique datasets from Chile and Ecuador on both the networks of supply chains and of joint ownership structures. The first Sub-Project focuses on international firm networks. It aims to analyze profit shifting of multinational firms to low tax jurisdictions, exploiting a natural experiment in Chile that strongly increased monitoring of international tax norms. The second Sub-Project investigates the analogous issue at the intranational level: profit shifting and tax collusion in networks of firms within the same country. Despite much anecdotal evidence, this behavior has received little rigorous empirical scrutiny. The final Sub-Project is situated at the nexus between international and national firms. It seeks to estimate a novel form of spillovers of FDI: the impact on tax compliance of local trading partners of foreign-owned firms. DEVTAXNET will provide new insights about the role of firm networks for tax evasion that are valuable to academics and policy makers alike.
Blue Ocean Secondary Oily Water Separator (BOSOWS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Faroe Islands
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2018-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

All ships produce oily bilge water. The MARPOL Convention requires vessels to have oily water separators and prohibits the discharge of water with more than 15 ppm oil content. Present techniques to clean bilge water on board include gravitational separation, adsorbents, flocculation, filtration and biotreatment. They are expensive, cumbersome and often unreliable under real life conditions at sea. Holding tanks on board are limited, some ports have insufficient reception facilities, and port delivery of oily water is expensive. Hence, 10-15% of all vessels regularly discharge illegally (OECD). Our inventions (pat. pending) for the first time enable separation of water from the disparate mix of oil, grease, detergents, solvents etc. in bilge water by common flash distillation. A working prototype superior to present solutions exists: it is insensitive to the ships motions and vibrations, reliable, requires less maintenance, employs no expensive and annoying filters, chemicals etc., and is easy to operate. Further, it exploits the engines cooling water for heating and seawater for cooling, and operates and cleans automatically. The Phase 1 funding will be spent on developing a business plan and a technical feasibility assessment, including testbed certification of the cleaned water, patent processing and freedom to operate examination. The customers for oily water separators are ship-owners, naval architects, shipyards etc. Their incentive to buy our separator is competitive price, and economical-, trouble-free and easy operation. The market is more than 6,000 units annually for new vessels and retrofitting. Phase 1 team: H. A. Djurhuus, the inventor, experienced ship-engineer. Responsible for the technical feasibility study. L. Johannesen, electrician, AP Graduate in Service Engineering and ship-engineer. Responsible for the PLC programming and electronics. P. M. Jacobsen, MSc. in Economics, MBA in Shipping & Logistics. Responsible for business development.

Keywords: ships bilge oily water,marpol convention,environment,discharge to sea
The Impact of Legal Recognition of Sign Languages on Sign Language Users and Deaf Communities (LRSL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-01
End date: 2024-08-20
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

The Legal Recognition of Sign Languages project (LRSL) aims to interrogate whether legal recognition of Sign Languages (SLs) actually provides Deaf people and SL users with realisable and enforceable rights. Using a socio-legal approach, LRSL investigates both the laws and the experiences of SL recognition in three European jurisdictions: Finland; Ireland and the United Kingdom. Semi-structured interviews will be conducted with Deaf representatives from Deaf Organisations to investigate how legal recognition is actually impacting Deaf people and Deaf Communities. In combining legal research and qualitative research, LRSL will provide an understanding of the necessary steps for implementation of rights that are meaningful and effective for Deaf people and SL users. LRSL will provide valuable insight into effective and ineffective mechanisms used to give agency and rights to Deaf Communities over their languages and culture. The research will provide unique and vital analysis and understanding of best-practices for the implementation of legal recognition of SLs, or the amendment of pre-existing legal recognition. LRSL will provide a roadmap for future efforts to recognise SLs in law within other jurisdictions. This roadmap will be made available to Deaf people and Organisations, activist groups, policymakers and legislators to aid in the implementation or amendment of legal recognition for SLs.

Keywords: deaf,sign language,language,minority rights,minority language,legal recognition
Unobtrusive Health Monitoring System for the Early Detection of Heart- and Micturition-Related Diseases (EarlyCare)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-09-18
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

EarlyCare project aims at developing and implementing cutting-edge sensing technologies and advanced Artificial Intelligence (AI) techniques to create a Health Monitoring System enabling early prediction of Diabetes Mellitus (DM) and Congestive Heart Failure (CHF), through the continuous monitoring of vital signs of older adults’ living alone related to micturition and cardiac activities as well as their warning signs. The innovative aspect of EarlyCare solution is the efficient deployment of completely nonwearable, unobtrusive, and privacy-friendly devices such as gas sensors and wireless physiological sensors which are coupled with explainable AI to detect and analyse the underestimated warning signs (i.e., nocturia and pollakiuria as abnormal micturition activity, arrhythmia and breathlessness). The AI-powered systems will be trained using publicly accessible sets and refined during the first phase of piloting. EarlyCare will be integrated into an interoperable IoT platform (enSenior) and validated on voluntary patients. The successful conclusion of this project will contribute to promote healthy ageing and reduce burden of formal and informal caregivers of older adults by advancing in development of eHealth tools and smart devices. The proposed multidisciplinary research activities, training, transferable skills and secondments will grant the improvement and acquisition of the most appropriate skills for his future career development.

Keywords: health monitoring system,gas sensors,physiological data analysis,machine learning,explainable artificial intelligence
Intelligent corrosion management underpinned by advanced engineering science (INTELLICORR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-07-01
End date: 2021-04-30
Duration (months): 46.0
Total project cost (EUR): 955710.0
EU funding (EUR): 955710.0
Participants: 1
Project status: CLOSED

Our planet’s population will continue to grow rapidly; between 2010 and 2025 the population will grow by 1.1bn. Urbanisation and growth of the consumer class in developing countries will lead to unprecedented demands on energy. There is arguably no bigger challenge to society than ensuring the security of affordable and environmentally-sustainable energy. Hydrocarbons will provide a large proportion of the world’s energy for the foreseeable future. There is no escape from the critically low oil price worldwide. Innovation becomes important in this price environment. “Easy” oil has already been found; future supply will come from complex reservoirs requiring enhanced oil recovery (EOR). There is a massive growth in renewables technology; the EU is making steady progress towards its 2020 target. The EU renewables energy share increased from 8% to 15% in the decade to 2013. Energy supply and consumption brings with it the global issue of climate change as emissions from industry and transport increase. Inextricably linked to energy is the reduction of the global carbon footprint and Carbon Capture and Storage (CCS) offers the only real technology that can handle the already produced carbon dioxide. Corrosion in energy and environmental control linking to energy supply provide the underpinning rationale for this proposal. Corrosion is one of the major life-limiting factors for energy supply (oil and gas, renewables, EOR) and in environmental pollution control (CCS) and is estimated to cost 3% GDP. This proposal brings some of the most exciting experimental and modelling engineering science to create a framework for the intelligent management of corrosion. INTELLICORR will use synchrotron techniques, advanced microscopy, numerical methods and environmental/cost analysis to bring about unprecedented advances in (a) prediction and management of localised pitting corrosion and (b) novel methods for green corrosion protection using the natural corrosion product layer

Keywords: corrosion,synchrotron,electrochemistry