Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ensuring the success of the next FET Conference and exhibition at a key period for FET (FET-Event)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: France
Call: Coordination and Support Activities (H2020-FETOPEN-2014-CSA, 2014)
Start date: 2015-09-01
End date: 2016-11-30
Duration (months): 15.0
Total project cost (EUR): 998750.0
EU funding (EUR): 998750.0
Participants: 2
Project status: CLOSED

The overall objective of the FET-Event project is to efficiently support the organisation of the next edition of the FET event, addressing in particular pre-conference communication, local organisation, participant assistance, and post-conference follow-up. The 3rd edition of the FET conference and exhibition is a long-awaited one since the previous one was held in 2011 and since FET has reached a new dimension: a new mandate going beyond ICT, newly launched large-scale initiatives, and a much larger budget. In this context, the 3rd edition of the FET event has to be highly successful (over 1200 registered participants and 30 exhibiting organisations), and reach the highest impact among targeted stakeholders (researchers, policy and decision makers, innovators and entrepreneurs, educators and schools, press and media, general public) To reach these objectives, the FET-Event partners have chosen the following approach: • Maintaining a close liaison with the FET Units and the FET Advisory Group all along the project • Developing synergies with the other CSAs selected at the Call • Ensuring the full engagement of FET past and ongoing projects in the conference • Shaping a highly creative event spreading over several days (“FET Week” concept), a multi-faceted one relying on several locations in order to succeed attracting all targeted stakeholders Moreover, the FET-Event project will evaluate the possibility for the FET event to become self-sustainable, to be organised every year / two years, still under the aegis of the European Commission and in close liaison with the FET Units but without any further grants provided through successive CSAs. The FET-Event consortium is compact and complementary. It only counts two partners offering a good knowledge of the FET programme and a longstanding experience in the organisation of large-scale events. It is coordinated by Sigma Orionis and ERCIM who had coordinated the CSA supporting the organisation of FET11.

Keywords: future emerging technologies,conference,exhibition
Arranging the Particles: Step Changing Chemical Measurement Technology (PrintPack)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Belgium
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 2488812.5
EU funding (EUR): 2488812.5
Participants: 1
Project status: SIGNED

The progress in liquid chromatography (LC), basically following Moore’s law over the last decade, will soon come to a halt. LC is the current state-of-the-art chemical separation method to measure the composition of complex mixtures. Driven by the ever growing complexity of the samples in e.g., environmental and biomedical research, LC is constantly pushed to higher efficiencies. Using highly optimized and monodisperse spherical particles, randomly packed in high pressure columns, the progress in LC has up till now been realized by reducing the particle size and concomitantly increasing the pressure. With pressure already up at 1500 bar, groundbreaking progress is still badly needed, e.g., to fully unravel the complex reaction networks in human cells. For this purpose, it is proposed to leave the randomly packed bed paradigm and move to structures wherein the 1 to 5 micrometer particles currently used in LC are arranged in perfectly ordered and open-structured geometries. This is now possible, as the latest advances in nano-manufacturing and positioning allow proposing and developing an inventive high-throughput particle assembly and deposition strategy. The PI's ability to develop new parts of chromatography will be used to rationally optimize the many possible geometries accessible through this disruptive new technology, and identify those structures coping best with any remaining degree of disorder. Using the PI's experimental know-how on microfluidic chromatography systems, these structures will be used to pursue the disruptive gain margin (order of factor 100 in separation speed) that is expected based on general chromatography theory. Testing this groundbreaking new generation of LC columns together with world-leading bio-analytical scientists will illustrate their potential in making new discoveries in biology and life sciences. The new nano-assembly strategies might also be pushed to other applications, such as photonic crystals.

Keywords: separation science,liquid chromatography,microfluidics,lab on a chip,ordered hierarchical materials
Chromatographic micro-column development for pharmaceutical applications in zebraFish (ChromaFish)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-09-15
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

ADME (Absorption, Distribution, Metabolism and Excretion) studies focus on the examination and prediction of drug behavior in the human body. Zebrafish present a good in vivo model for this purpose since they comply with the 3R principle of humane animal research (Replacement, Reduction and Refinement). The research group of Prof. Deirdre Cabooter recently developed a novel sample preparation and analytical method to accurately measure the whole-body uptake of drugs in zebrafish. The next step is to further exploit the developed methodology to study other aspects of ADME, in particular uptake and metabolisation of new drug candidates in the brain. Since the blood-brain barrier is a major obstacle preventing many pharmaceuticals from achieving effective concentrations in the brain, infinite small concentrations are to be expected. The detection of low brain concentrations can be improved by using advanced analytical techniques with lower sample dilution and thus enhanced detection limits. An important part of this research project will therefore be devoted to the development and characterization of new capillary column formats based on core-shell particles offering unprecedented sensitivity and unique selectivities. A new brain dissection technique will moreover be developed to isolate the brain from the circulating blood and investigate the uptake and metabolisation of selected pharmaceuticals in the brain. Molecular transport routes will be unraveled and the uptake in specific parts of the brain will be investigated as well using laser microdissection microscopy. Finally, the potential of the developed methodology to provide a robust protocol for brain uptake measurements in industrial applications will be investigated by comparing the outcome obtained by zebrafish experiments with typical results obtained by more traditional models (murine, rat).

Keywords: high performance liquid chromatography,capillary columns,core shell particles,mass spectrometry,adme studies,pharmaceutical uptake in zebrafish
Personalised Image-based Computational Modelling Framework to Forecast Prostate Cancer (PICModForPCa)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 251002.56
EU funding (EUR): 251002.56
Participants: 2
Project status: SIGNED

Prostate cancer (PCa) is a major health problem among ageing men worldwide, especially in Europe. However, the medical management of PCa only offers limited individualisation and has led to significant overtreatment and undertreatment, which may compromise patient quality of life and survival respectively. Active surveillance is a clinical strategy in which patients with life-threatening PCa are directed to treatment while those with indolent tumours remain closely monitored via regular clinical tests and medical imaging. Multiparametric magnetic resonance imaging (mpMRI) provides high-quality data on PCa and is increasingly used in its diagnosis and surveillance, but computationally exploiting the wealth of data in these images to obtain precise information on tumour evolution to guide clinical management is an unresolved challenge. To address this timely issue, this project proposes to derive a personalised predictive mathematical model of PCa based on mpMRI to run organ-scale simulations that improve diagnosis and forecast the patient’s tumour evolution. The model will rely on robust biological and mechanical phenomena described via differential equations whose parameters are identified voxel-wise by solving an inverse problem using the patient’s clinical and mpMRI data at two dates. The model will then be validated by comparing simulation and actual data at a posterior date. The resulting predictive technology offers an unparalleled advance to personalise and optimise active surveillance for PCa, hence meeting many European Commission priorities for research in cancer. The candidate has previously developed computational models and methods to study PCa growth in clinical scenarios. Building on this ideal background, this project will provide him with crucial scientific techniques and skills to become a leading independent researcher, produce high-impact oral and written communications, and start an active network of collaborations between the US and Europe.

Keywords: prostate cancer,active surveillance,multiparametric magnetic resonance images,computational oncology,patient specific,organ scale,isogeometric analysis,inverse problems,biomechanics
Metamorphosis as a driver of biodiversity? From a single genome to multiple phenomes (META-MORPHOSIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

Metamorphosis is one of the most fascinating phenomena in the animal kingdom, implying an abrupt change in morphology and ecology during the lifetime of an individual transforming it from a larva into an adult. Metamorphosis can be thought of as a second birth for an animal, emerging as a completely different organism, despite being produced from the same genetic material. From butterflies to frogs, almost all the successful and speciose lineages of animals are metamorphic, suggesting that metamorphosis may be an important driver of biodiversity. At the time of the sixth mass extinction, where one-fifth of living species are threatened, understanding whether development can be a driver of morphological and functional diversity, and whether it may be advantageous in allowing populations to adapt rapidly to changing environments is of prime importance. The goal of META-MORPHOSIS is to test the impact of metamorphosis on morphological diversification by disentangling the factors (developmental, functional, and ecological) shaping morphological diversity. I aim to 1) identify the patterns of morphological and functional variation depending on developmental strategies across species throughout ontogeny; 2) shed light on the origin and evolution of metamorphosis using the fossil record; 3) understand how metamorphosis fosters diversity and to quantify its impact on the generation of biodiversity. To do so, I will study salamander species with different developmental strategies and ecologies throughout ontogeny using a combination of state-of-the-art approaches, including phenomics (geometric morphometrics), analyses of function (feeding kinematics and forces), phylogenetic comparative methods, development, paleontology and methods exploring diversification. META-MORPHOSIS will produce an unprecedented data set and analyses of diversification considering for the first time how morpho-functional, developmental, and ecological factors shape biodiversity through deep-time.

Keywords: metamorphosis,functional morphology,head,salamanders,development,diversification
Development of standardised innovation services through peer learning to efficiently increase innovation management capacity among SMEs (INNOWEST)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany,Sweden,United Kingdom
Call: peer learning of innovation agencies (H2020-INNOSUP-2014-5, 2014)
Start date: 2015-09-01
End date: 2016-04-30
Duration (months): 8.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

Many SMEs are not willing to invest time and resources in developing their internal innovation systems. The lack of innovation management capacity among Swedish SMEs might very well be the main reason why certain government support schemes to Swedish innovative SMEs do not indicate any significant impact. The support actions "Enhancing the innovation management capacity of SMEs by the Enterprise Europe Network" in 2014 and 2015 includes a standardised innovation management capacity assessment (e.g. using IMP3rove), a gap analysis and the provision of targeted services to address recognised gaps. However, the action does not involve activities, methods or tools on how these gaps could be filled, only that they are recognised. The objective of this project proposal is to address these problems by using the tool Twinning Advanced to explore an innovation support challenge, which is to develop, design and re-design new and existing innovation services as standardised modules so that support organisations can assess the needs and deliver the most appropriate support more efficiently. The peer learning will take place between three innovation agencies, who are also partners in the Enterprise Europe Network, and with external expert organisations depending on the outcome. The result will be documented in a Design Option Paper (DOP) that will identify and document implementation options, guidelines and implementation alternatives that we have experienced and would recommend to other innovation support service agencies. The DOP would particularly address Enterprise Europe Network partners in Europe to meet common needs expressed by SMEs that need to increase their innovation management capacity. The specific objective is to document at least five such modules describing how to implement 1) an innovation strategy, 2) an innovation culture, 3) an innovation life cycle process, 4) enabling factors, and 5) a system for assessing outputs of innovation management.

Keywords: innovation management capacity,enterprise europe network,imp3rove,innovation strategy,innovation culture,innovation life cycle
Insect-repellent coating for food packages (INSECTBARRIER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2016-01-01
End date: 2016-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

More than 4 million packaging units of rice and dry pasta are lost every year as consequence of insect infestations at European level. This problem represents around one third of the complaints received by the food companies. European consumers are highly reluctant to find insects in the food they consumed and therefore a severe control of insect infestations is demanded. One sole infested package has huge economical consequences for food processors and retailers, estimated in €400 million in complaints and €10 million in un-sold products. In addition, the devaluation of the brand, the loss of consumer’s loyalty, and infringement of food safety regulations (EC 178/2002) can be highlighted. INESFLY CORPORATION, S.L. is a company founded in 1997 that has 14 employees and an annual turnover of €1,368,478. It is specialised in the research and production of new and more efficient products to combat all kind of arthropods and pests. INESFLY’s patented a technology based on the microencapsulation of active agents providing a longlasting activity. INSECTBARRIER proposes to transfer this technology from the current applications to the paperboard packaging. With INSECTBARRIER, we aim to launch our products into the food packaging sector by providing a specific coating solution for cardboard packages as those used to store, transport and distributed the packed rice and dry pasta. As a whole, sales of about €19 million are forecast within a five-year period, generating profits of over €2.4 million. During phase 1, a feasibility study including a business plan will be developed. This study will include: (1) a market assessment to confirm INESFLY’s products acceptance in the two food segments considered; (2) a technical assessment to validate our coatings according to paperboard converting procedures, as well as final testing; (3) a stakeholder assessment to identify the key players and activities for the second and third phases of the project; and (4) a complete Business Plan.

Keywords: insect repellent,cardboard packaging,active packaging,coating,microencapsulation,rice,pasta
Function of long non-coding RNA in Crohn Disease Ulcer Pathogenesis (cureCD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Israel
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-05-01
End date: 2024-04-30
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The Inflammatory Bowel Diseases (IBD), Crohn’s Disease (CD) and Ulcerative Colitis (UC) are chronic/relapsing disorders that affect over six million individuals worldwide. Mucosal ulcers, the hallmark of CD, are the result of a complex interaction between microbiota, immune cells, and gut epithelia. Healing of mucosal ulcers is associated with better outcomes, but is achieved in less than half of cases. Past attempts to suppress central and conserved nodes of the immune system failed due to opposing off-target deleterious effects on epithelial renewal. Therefore, there is a critical need to identify more tissue specific targets that lead to mucosal healing and to improved outcomes. Using mRNAseq of intestinal biopsies, we identified a widespread dysregulation of long non-coding RNAs (lncRNA) in the ileum of treatment naïve pediatric CD patients. Importently, we identified significant correlations between lncRNA and mucosal ulcers. CD lncRNA, after carful mechanistic exploration, are highly promising targets for potential future intervention as they regulate diverse cellular functions and exhibit a more tissue specific expression in comparison to protein coding genes. The core goal of this proposal is to understand the role of CD lncRNA in ulcer pathogenesis focusing on granulocytes and epithelial functions in the contexts of their interactions with the microbiota. I plan to utilize state of the art informatics, RNAseq and microbiome profiles together with advanced and novel experimental lab model and co-culture systems, patients-derived prospectively collected tissues, and gut microbiota to explore the role of CD lncRNA function in mediating healing of mucosal ulcers. This work carries the potential to guide new novel therapeutic strategies for mucosal healing with minimal off-targets effects. In a broader prospective, this work will expand our relative limited understanding regarding the role of lncRNA in mediating human diseases.

Keywords: crohn disease,ulcer,long non coding rna
PEER LEARNING FOR A DESIRED SCENARIO ON GREEN PUBLIC PROCUREMENT FOR INNOVATION (GREENIN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain,Hungary,Portugal
Call: Peer learning of innovation agencies (H2020-INNOSUP-2018-2019-05, 2018)
Start date: 2018-10-01
End date: 2019-09-30
Duration (months): 12.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

The GREENIN project aims to set up a desired scenario in green public procurement for innovation (GPPI) aligned with smart specialisation strategies, based on the “twinning advanced” methodology to increase knowledge exchange among partners and with policy makers and interested stakeholders, favouring SMEs participation by means of pilot actions. The project focuses on green since GPP stimulates eco-innovation which is one of the main focus of the smart specialisation strategies of the participating regions and contributes to the EU's efforts to become a more resource-efficient economy. Additionally, the project has an approach on innovation since PPI fosters new solutions in a shorter time-to-market and advice to SMEs on innovation is one of fields of expertise of the participating host organisations. A peer learning mechanism will be set up among the three partner agencies in order to allow them to jointly set up a desired scenario for GPPI based on existing policies, methodologies, experiences and good practices on GPPI. As a result, a GREENIN Design Option Paper will be designed, containing recommendations on possible policy schemes, methodologies and initiatives for the deployment of GPPI in European territories.

Keywords: peer learning,public procurement,innovation,business support,ris3,green economy