Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Spain,Belgium,Belgium,Greece,Lithuania,Norway,France,France,France,Czechia,Netherlands,Netherlands,United States,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal
Call: The Human Exposome Project: a toolbox for assessing and addressing the impact of environment on health (H2020-SC1-2019-Single-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2025-06-30
Duration (months): 66.0
Total project cost (EUR): 11998333.75
EU funding (EUR): 11998333.75
Participants: 28
Project status: SIGNED

ATHLETE aims to develop a toolbox of advanced, next-generation, exposome tools and a prospective exposome cohort, which will be used to systematically quantify the effects of a wide range of community-level and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways during the first 2 decades of life, to implement acceptable and feasible exposome interventions, and to translate the resulting evidence to policy recommendations and prevention strategies. ATHLETE will establish a prospective exposome cohort, including FAIR data infrastructure, building on Europe’s most comprehensive already existing exposome data (18 cohorts in 12 European countries). ATHLETE will systematically characterise the effects of the exposome on early organ development, health trajectories, and biological pathways (metagenomic, metabolomic, epigenetic, ageing, and stress pathways), longitudinally from early pregnancy through adolescence. Innovative tool development will focus on: 1) complete and accurate measurement of multiple environmental risk factors (external/urban, chemical, physical, behavioural, social) through new targeted and untargeted exposure science approaches, 2) development of advanced statistical and toxicological strategies to analyse complex multi-dimensional exposome data, 3) development of interventions to reduce personal exposures, co-produced with the community, and 4) estimation of the societal impact of the exposome by calculating costs and child health impacts. ATHLETE’s strong focus on the vulnerable early stages of the life course, widespread general population exposures and common non-communicable diseases, its use of a large body of existing exposome data and expertise, its strong emphasis on knowledge translation, its development of an open online toolbox and its close collaboration in the European Human Exposome Network ensure that the objectives are achievable and highly relevant for future research and policy. ATHLETE is part of the European Human Exposome Network comprised of 9 projects selected from this same call.

Keywords: exposome,environmental pollutants,pregnancy,childhood,adolescence,fair data management,exposure science,biological pathways,interventions,health impact assessment,knowledge translation
Mapping the impact of gut microbiota on brain and behaviour through the lens of GABA (GutBrainGABA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1997953.0
EU funding (EUR): 1997953.0
Participants: 1
Project status: SIGNED

Human beings are over 99% genetically identical. It seems striking therefore, that 1% of this genetic difference accounts for the large extent of individual variations seen in human behaviour and brain function. One promising alternative source of individual differences is the resident bacteria in the gastrointestinal tract, which is 40-90% distinct between different individuals. Bacteria in the human gut outnumber human cells, and account for nearly 10 times as much DNA as that from human cells. Some gut bacteria have been shown to produce Gamma Amino Butyric Acid (GABA) and serotonin (5-HT), molecules that function as neurotransmitters in the human brain. However, it is not known whether their production in the gut has any impact on behavioural and brain function. This project takes a biochemically informed approach to address this gap in knowledge through focussing on GABA, whose function as a neurotransmitter is well characterised, and which can be assayed directly or through proxy measures of brain and behaviour. The first work package of this project in human adults will investigate whether the population of gut bacteria capable of producing GABA can modulate brain levels of GABA (measured directly using Magnetic Resonance Spectroscopy), as well as performance in tasks that depend on GABA-ergic activity. The second work package will test the impact of ingesting bacteria known to produce GABA (packaged as a custom-made probiotic) over a period of four weeks, on the same brain and behavioural measures. Together, these studies will answer a fundamental question of whether the population of gut bacteria capable of producing GABA, as well as its modulation by probiotics, has any impact on the level GABA in the brain and its function. This interdisciplinary proposal brings together approaches from psychology, neuroscience, and gut microbiology to chart a new research frontier in understanding individual differences in human behaviour and brain function.

Keywords: gut microbiota brain,individual differences
Populism and Conspiracy Theory (PACT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-04-01
End date: 2025-03-31
Duration (months): 60.0
Total project cost (EUR): 1998375.0
EU funding (EUR): 1998375.0
Participants: 1
Project status: SIGNED

The last two decades have seen the rise of populist movements and parties in Europe, the Americas, Asia, and Africa. Over the same period, conspiracy theories have also significantly gained in visibility and impact. As any casual observer of contemporary politics knows, the two phenomena are connected. Populist leaders often use conspiracist rhetoric, and many of their followers are receptive to it. Previous research has highlighted parallels between the two phenomena (such as Manicheanism and simplification) but left important questions unanswered. When, how, why, and to what effects do populists articulate conspiracy theories? Are they more prominent on the right than on the left? Does their significance change when parties move from the opposition into power? How do populist movements deal with the fact that some of their members believe in conspiracy theories, but others do not? To answer these and related questions, this interdisciplinary project will analyze the role of conspiracy theories for currently successful populist movements in the United States, Brazil, Austria, Hungary, Italy, and Poland. Paying close attention to national, media, and other contexts, it will examine the significance of conspiracy theories for party leaders as well as for ordinary members. Methodologically, the project will combine Critical Discourse Analysis (of speeches, party manifestos, social media etc.) with ethnographic fieldwork (participant observation and semi-structured interviews) to provide a holistic and comprehensive account. Conceptually, the project will combine the ideational and discursive-stylistic approaches to populism. A similar investigation has never been undertaken. The project’s results have potential implications beyond the academic realm. They will not solve the problems that populism and conspiracy theory pose. But there is a fair chance that they will help to meet better the challenges that they currently pose to liberal representational democracy.

Keywords: populism,conspiracy theory,communication,social media,democracy,collective identity,othering
Information encoding to polymers (POLINFO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Data acquisition and mining is currently the principal driving force of technological advances. Massive expansion of the field requires implementation of new solutions in data storing and retrieving, where targeted solutions need not only be resource-sustainable and recyclable, but also have to posses high information-encoding density to decrease space allocated for storage. Polymers represent natural candidates for the task, as nucleic acids already efficiently encode for vast biological complexity. However, the synthesis of long sequence-ordered polymers in vitro has proven to be challenging and remains an open question. Our project aims to address whether conditions of spontaneous sequence ordering can be achieved under non-equilibrium conditions. To that extent, we build a computational model that bridges a coarse-grained representation of polymer with stochastic kinetics modelling of polymerization and depolymerization reaction. The model is a novel approach to exploring information encoding to polymers, as it is not limited by master equation solution feasibility, and allows, for the first time, to interpret the informational content of the generated sequence through its effect on polymer structure. We explore novel theoretical ideas on non-equilibrium systems that have recently emerged, suggesting that spontaneous ordering of systems takes the path of maximum heat dissipation, which we plan to test for the first time in the context of information generation. In addition, we aim to understand the timescales pertinent to sequence ordering under non-equilibrium conditions, where specifically the concentration number of monomer types is varied in time. Finally, we wish to understand the conditions which allow for creation of autocatalytic self-replicative sequence sets, with emphasis on timescales relevant to this process. Overall, we aim to identify timescales pertinent to generation of ordered sequences, which could pave way to new experimental strategies.

Keywords: stochastic thermodynamics,polymers,information encoding,biophysics,coarse grained model,non equlibrium conditions
Biomechancial Aneurysm Risk Assessment Trial (BARAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Austria
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-03-01
End date: 2015-10-31
Duration (months): 8.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The formation of aortic aneurysms is the by far the most common aortic disease and its prevalence (1%-5% in the 65+ population) strongly increases with age. Expensive aneurysm repair interventions (about 60k per year in Europe) are performed in order to prevent aortic aneurysms from rupture. However, oversimplified criteria like the maximum transverse aortic diameter or the aortic expansion rate are used to indicate aneurysm repair. These criteria fail to provide patient-specific (individualized) treatment indication, such that many patients are treated without a reason and health care resources are wasted. In contrast VASCOPS’ A4clinics software allows a detailed biomechanical rupture risk assessment, and hence, allows prioritizing patients according to their individual risk of aortic rupture. The market volume for such diagnostic information is estimated to 12000k€ per year in Europe. A4clinics is patented, CE approved and achieved already Technology Readiness Level 9. Despite first retrospective validation studies demonstrated the clinical benefit of the system large prospective validation is needed to fully convince clinicians and to commercially exploit the product. Consequently, the aim of this proposal is to develop a clinical validation plan for the A4clinics software, which is tightly linked to its successful large-scale commercialization. Key points are the definition of a targeted validation strategy and the installation of an effective network of clinical partners, who also should serve as national contact points for product commercialization. In addition early measures to gain awareness of the validation initiative and links to product distribution plans are investigated. The planning will be performed in collaboration with our clinical contact at Karolinska University Hospital in Stockholm, Sweden. Stockholm area screens for aneurysm patients, and, as such provides latest, and for most European countries, a future health care environment.

Keywords: abdominal aortic aneurysms,vascular,analysis,validation,biomechanics,patient specific,rupture risk assessment,rupture risk index,life science,vascular center,surgery,diameter
Contested urban territories: Ethnographic concept building for a more global urban theory (Decolonizing Ecology)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-04
End date: 2023-10-03
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

Indigenous movements in Latin America exemplify alternatives ways of relating to urban nature. These different practices and ecological imaginaries at play in urban contexts could signal different routes for a more sustainable development. Yet, they remain under-investigated, this proposal argues, due to a lack of an adequate conceptual repertoire and methodological tools to analyse these practices. This is despite new starting points for a more global urban theory: while post- and decolonial scholars have argued to further diversify socio-spatial theory, scholars engaging with an ontological turn are rethinking dualisms separating nature and culture or urban and rural to open up new grounds to study urban political ecology. This project addresses this gap by building on Latin America-based scholarship to reframe these types of socio-environmental struggles as urban contestations, emphasising intersectional dimension of indigeneity, race and gender, to understand these multiply scaled processes. The main questions are: What practices do indigenous urban movements mobilize to defend their right to territory? How do the urban worlds enacted through these practices challenge and inform concepts and methods in urban studies more widely? Empirically, the research builds on a systematic comparative study of Mexico City (Mexico) and La Paz-El Alto (Bolivia) – cities marked with indigenous urban movements and rapid urbanization. This research will demonstrate novel strategies to compare different ecological and urban understandings. By advancing an interdisciplinary approach to analyse environmental conflicts in cities, the project will contribute to knowledge on urban development and provide a sound base to put forward suitable policy instruments to work towards sustainable cities and communities.

Keywords: comparative urban studies,social geography and ecology,urbanization and urban development,ontological turn,socio territorial movements,latin america
ISOTOPIC LABELING FOR DRUG INNOVATION (ISOTOPICS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Belgium,Sweden,Belgium,France,France,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 3948843.96
EU funding (EUR): 3948843.96
Participants: 13
Project status: CLOSED

Excessive attrition rates during clinical trials dramatically impact on Drug Discovery and Development (DDD). Absorption, Distribution, Metabolism and Excretion studies carried out on larger series of drug candidates at an earlier stage of the DDD timeline and evaluation of drug efficacy through better assessment of pharmacokinetic/pharmacodynamic relationships, target engagement and receptor occupancy are critically important approaches for de-risking drug innovation since they facilitate early identification of the candidates that display the best in vivo profile. When successfully implemented, this strategy can accelerate the discovery of new therapeutic solutions to existing and emerging diseases, and enhance European pharmaceutical innovation. For implementation, large sets of isotopically-labeled molecules are required and consequently, a huge revival of labeling techniques is urgently needed. Another crucial issue is the scarcity of expert radiochemists in Europe and the lack of first class training programs in this inter-disciplinary field merging chemistry, radiochemistry and medicinal chemistry. The aims of ISOTOPICS are: i) to train the next generation of European chemists with expertise in isotopic labeling and advanced medicinal chemistry through a first-class taught and research training program combined with a highly interactive secondments plan; ii) to develop innovative and general isotopic labeling chemistry and radiochemistry to streamline the synthesis of labeled small-molecule drugs and biologics; iii) to work closely with the European pharmaceutical industry to apply the new labeling methods to drugs currently in development in order to provide solutions to the most pressing problems in drug innovation. This highly interdisciplinary project is expected to have a profound beneficial impact on drug innovation in Europe by providing novel efficient techniques and new experts in the fields of labeling and medicinal chemistries.

Keywords: isotopic labeling,drug discovery,adme studies,preclinical studies,molecular imaging,deuterium,tritium,carbon 11,carbon 14,fluorine 18,beta imaging,animal testing
Enhancing the Innovation Management Capacity of SMEs (by EEN), Slovenia (We4SMESLO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Slovenia,Slovenia,Slovenia
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 64820.0
EU funding (EUR): 64820.0
Participants: 8
Project status: CLOSED

The EC has within its Survey of 2011, carried out on request of DG Enterprise and Industry (DG EI), realized that the main barriers of innovation in the eyes of the SMEs, are lack of financial resources and inability to manage innovation process. Since different understandings of the term "Innovation Management System" (IMS) have been noted the EC has supported European Committee for Standardization to provide the stakeholders with a unified definition of relevant parts in the IMS. According to this definition the most important parts of IMS include company's innovation processes from idea generation to innovation result, but also leadership, management skills and other enabling factors, like the ability to cooperate with third parties like RD partners, clients, and suppliers. The objective of this project in Slovenia is to enable SMEs to bridge the knowledge gap in innovation management, get aware of shortages and improve their internal innovation management system and/or focus on achieving market value with their inventions. The consortium will achieve this objectives with providing: 1.) Enhancing the Innovation Management Capacity of SMEs. The beneficiaries will receive diagnostic of their innovation system based on the standardized IMP³rove tool. This will lead to the formation of tailored action plan to improve the SME’s capacity to better manage innovation. 2.) Key Account Managers – Facilitators for the H2020 SME Instrument. Key Account Managers will identify and source appropriate lead coaches (from predefined pool of coaches), facilitate linking the SMEs to innovation support services and to support the lead coach in delivering services to the SME. The SME Instrument participants will receive the most appropriate services and support to enhance the probability of successful exploitation of the innovation project and to leave a footprint for the future sustainable growth of these beneficiaries.

Keywords: sme instrument,innovation management,imp3rove,key account manager
SecondHands: A Robot Assistant For Industrial Maintenance Tasks (SecondHands)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Advanced interfaces and robots: Robotics and smart spaces
Action type: Research and Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Germany,Italy,Switzerland,United Kingdom,United Kingdom
Call: Robotics (H2020-ICT-2014-1, 2014)
Start date: 2015-05-01
End date: 2020-04-30
Duration (months): 60.0
Total project cost (EUR): 6930000.0
EU funding (EUR): 5994000.0
Participants: 6
Project status: CLOSED

The subject of this proposal is a robot assistant that is trained to understand maintenance tasks so that it can either pro-actively or as a result of prompting, offer assistance to maintenance technicians performing routine and preventative maintenance. Conceptually the robot's task is to provide a second pair of hands to the maintenance engineer, such that once the robot has been trained it can predict when and how it can usefully provide help. The robot's behavioural repertoire is learnt in a training phase that includes the monitoring of maintenance technician activity, the construction of a knowledge base that describes the context of a task, and a theory of action that enables dynamic behaviour generation. The result is a set of competencies coupled with an ability to recognise the state of a task and an understanding of how these competencies can be usefully deployed given the state. The scope of work includes the construction of a robot assistant, the systems that facilitate the training, the actual training on a number of representative tasks, perceptual systems that facilitate activity recognition, and validation of the system's ability to usefully contribute to tasks in collaboration with a maintenance engineer. Assessment of the system will test its ability to recognise when it doesn't know something as well as its ability to generalise its knowledge to previously unseen tasks.

Keywords: pro active assistance,task understanding,second pair of hands,automation maintenance