Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Automated Cultured Meat Platform (ACMP) - Automated Plug-and-Produce System for the Resource-Efficient Production of Cultured Meat on an Industrial Scale (ACMP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Innocent Meat GmbH is developing an innovative production platform for cell-based cultured meat on an industrial scale that offers meat processors an automated and sustainable alternative to industrial animal farming as a “plug-and-produce” system. The project aims to build a large-scale demonstration plant in Germany capable of producing minced meat on a large scale. The aim is to demonstrate the technical feasibility and efficiency of continuous operation at this industrial scale. The technology platform combines process automation with an integrated solution for all production steps from cell culture to the final product, specifically tailored to the needs of industrial production. The goal of the project is to develop an industrially scalable solution that will enable the transformation of much of the meat industry towards sustainable, ethical and future-proof practices.

Keywords: cultivated meat,manufacturing,manufacturing as a service,new materials,iot,biotechnology,health,recombinant proteins,tissue engineering,farm to fork strategy,food system,transition,
Drivers of Demographic Dynamics (DEMODRIVERS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2765537.0
EU funding (EUR): 2765537.0
Participants: 1
Project status: SIGNED

This project aims to reconstruct the human demography of SW Amazonia during the Holocene and to reveal the role of environmental and cultural changes in shaping it. Despite decades of research, the relative importance of environmental vs cultural factors in determining prehistoric population growth is still one of archaeology’s greatest scientific challenges. Reaching an agreement about the drivers of demographic dynamics is very difficult because of the fragmentary, incomplete and biased nature of archaeological records. DEMODRIVERS is designed to overcome this problem. This five-year interdisciplinary project will investigate the patterns and drivers of human demographic dynamics by focusing on a regional case study, the Llanos de Moxos (LM) in the Bolivian Amazon, that has a potentially unparalleled explanatory power. This region at the southwestern end of the Amazon hosts a recently discovered, almost complete archaeological record, made up of 4700 sites spanning 8300 years and distributed over 100,000 km2. This area is unique in the world, offering us the first opportunity to quantify how far demographic trends and patterns responded to exogenous (climate, landscape) and endogenous (culture, technology) variables. This project will exploit the full potential of the LM archaeological record by taking an unconventional approach: the density of the occupation and its spatial and temporal boundaries will be measured by studying 150 stratigraphic cores extracted from 100 evenly distributed archaeological sites. The approach is interdisciplinary, integrating conventional archaeology with state-of-art geoarchaeology, biomarkers, paleoclimatology, palaeoecology and artificial intelligence. The results of the project will provide a very thoroughly documented case study against which other models and reconstructions based on incomplete, fragmented and often biased datasets can be compared. The results of the project have broad implications across several disciplines.

Keywords: amazonia,archaeology,sedentism,paleoenvironment,paleoclimate,geochemistry,biomarkers,phytoliths,isotopes
Wireless, Low-Cost, Low-Power Integrated Sensor Photonics (WILLOWISP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Ireland,United Kingdom
Call: Transition Open 2024 (HORIZON-EIC-2024-TRANSITION-01, 2024)
Start date: 2025-04-01
End date: 2028-03-31
Duration (months): 36.0
Total project cost (EUR): 3128889.04
EU funding (EUR): 2495031.9
Participants: 2
Project status: SIGNED

Fugitive methane emissions (“FME”) from fossil fuels account for 20% of total methane emissions. Fugitive emissions are the result of loss of well and pipeline integrity, particularly in aging or decommissioned infrastructure. Emissions are largely self-reported by fossil fuel companies, and one survey indicated leaks from approximately 47% of active wells in the area indicating that actual methane emissions may be much higher than that reported by industry or estimated by government. Gas Analysers based on the current mid infrared (mid IR) Laser Absorption Spectroscopy technology are still complex, delicate and expensive, which limits their potential for deployment. WILLOWISP will combine four recent breakthroughs to make an ultraportable gas analyser for methane, which will be lightweight, streamlined and fully self-contained comprising the laser, photothermal transducer, gas management and electronics. We will reduce a spectroscopy system that currently occupies 1m2 on an optical bench to a 5cmx5cm footprint, with the same and potentially better performance relative to the benchtop system. The system will be capable of operating in environments that are challenging to traditional spectroscopy systems such as small unmanned aerial vehicles. WILLOWISP will realise a separate transducer chip and excitation chip that are indirectly coupled via the photothermal effect in the analyte, No optical elements (lenses, mirrors, fibres etc) are required to couple the two chips. As a result, our gas analyser will have very high vibration and shock resistance. The two photonic chips can be assembled with standard electronics industry high throughput pick-and-place assembly tools. This simplicity and compactness translate into significantly reduced costs, by at least two orders of magnitude, creating a great opportunity for a spin-out company.

Keywords: fugitive methane,nanophotonics,silicon photonics,photonic integration,laser absorption spectroscopy
Uncovering the effects of pharmaceuticals in the wild, beyond individuals to animal communities (AquaDrugs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 2
Project status: CLOSED

The increasing production and release of pharmaceutical pollutants into waterways is now a leading threat to aquatic wildlife and ecosystems around the world. Despite this, knowledge on the hazards these contaminants cause in complex natural ecosystems is still extremely poor and thus considered an urgent research priority. AquaDrugs will harness new developments in underwater animal tracking and computer automation to identify how pharmaceutical waste in the environment can induce behavioural changes in animals that lead to high-order ecological effects. Through a series of well-integrated experiments, and using fish as a model system, AquaDrugs will trace the impact of pharmaceuticals across biological scales to address four novel and ambitious objectives: (1) test how environmentally relevant concentrations of two globally pervasive pharmaceuticals (clobazam an tramadol), both in isolation and in a mixture, influence ecologically important wildlife behaviours and variability; (2) identify whether, and how, such changes impact animal collectives; (3) determine how pharmaceutical-induced behavioural changes at the individual and group levels scale up to shape aquatic communities; and (4) uncover how exposure shapes the ecological interactions of multiple species. The project will deliver urgently needed data for chemicals regulation leading to improved policies that safeguard Europe’s aquatic ecosystems and wildlife from pharmaceutical impacts. The interdisciplinary approaches and theory in AquaDrugs—from integrative ecology, ecotoxicology, and analytical chemistry—also promises to yield pioneering results and experimental innovations that will advance these scientific fields and boost the expertise and academic career of the research fellow, Dr Marcus Michelangeli. Importantly, the research in AquaDrugs directly addresses key research priorities in Europe including the European Green Deal and the EU’s Mission for ‘Healthy Oceans, Seas, and Inland Waters’.

Keywords: pharmaceutical pollution,movement ecology,collective behaviour,animal personality,behavioural variation,aquatic toxicology
Change toolkit for digital building permit (CHEK)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Countries involved: Netherlands,Italy,Portugal,Spain,Germany,Bulgaria,North Macedonia,Luxembourg,Poland,United Kingdom,Czechia,Belgium
Call: Digital permits and compliance checks for buildings and infrastructure (IA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 5644248.8
EU funding (EUR): 4917856.07
Participants: 19
Project status: SIGNED

Today's building permit issuance is mainly a manual, document-based process. It therefore suffers from low accuracy, low transparency and low efficiency. This leads to delays and errors in planning, design and construction. Several EU countries have developed attempts to push forward the digitalisation of building permit procedures. But none of these have led to complete adoption of digital building permit processes within municipalities. The aim of CHEK is to take away barriers for municipalities to adopt digital building permit processes by developing, connecting and aligning scalable solutions for regulatory and policy context, for open standards and interoperability (geospatial and BIM), for closing knowledge gaps through education, for renewed municipal processes and for technology deployment in order to reach TRL 7. CHEK will do this by providing an innovative kit of both methodological and technical tools to digitise building permitting and automated compliance checks on building designs and renovations in European urban areas and regions. The CHEK consortium consists of a multidisciplinary team covering GIS, BIM, municipal processes and planning, data integration and standardisation. In addition, the consortium is a multisectoral mix of research&education, AEC- and software-companies, governmental institutions, and international standardisation organisations. The multisectoral and multidisciplinary consortium is essential to align and connect all aspects of digital permit processes required to meet the highly ambitious project objectives. Several partners are already collaborating in the European Network for Digital Building Permit (EUnet4DBP). The institutions in the advisory board, representing governments and municipalities of other European countries, will further assist the development, exploitation, and upscaling of results. The best practices and developed software following the logic of OpenAPI will enable replicability in any other European country.

Keywords: geo,bim,digitalisation of building permits,aec,building design,renovation
Exploring the impact of gut microbiota-derived octadecanoids on mucosal healing (GUTMATES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-04-01
End date: 2028-03-31
Duration (months): 24.0
Total project cost (EUR): 236340.0
EU funding (EUR): 236340.0
Participants: 1
Project status: SIGNED

The microbiota-host crosstalk is crucial for several processes in the gut and its dysregulation is a hallmark of diseases such as colorectal cancer (CRC) and inflammatory bowel disease (IBD). Despite its key relevance for a holistic understanding of human (patho)physiology, how this crosstalk affects the cellular and molecular programs in the intestine remains is yet to be fully understood, mainly due to a lack of suitable technologies and models. It is known that one of the ways that the gut microbiota interacts with the host is via metabolite production. Among these, octadecanoids, lipid mediators from 18-carbon (18-C) polyunsaturated fatty acids, are poorly studied in the context of the gut despite their high abundance and diversity. Studies on this topic have only focused on inflammation, neglecting the mucosal healing response, highly relevant for IBD outcome and CRC tumorigenesis. In GUTMATES, I will use a new zebrafish model of intestinal damage/regeneration- and organoid-based screening platforms, together with murine colitis models, spatial transcriptomics, metabolomics, metagenomics, and clinical readouts to visualize the effect of microbial octadecanoids in intestinal regeneration. This project will provide the first large-scale exploration of how these metabolites modulate the mucosal healing process in vivo, as well as giving a multi-omic atlas of the impact of selected 18-C compounds in the mouse colon during regeneration. My ultimate aim with GUTMATES is to have a comprehensive view of the mucosal healing landscape given by gut microbial octadecanoids, to eventually find compounds or microbes that can be exploited for regeneration-based therapies in IBD and biomarkers for CRC.

Keywords: intestinal regeneration,gut microbial metabolites,lipid mediators,zebrafish,organoids,inflammatory bowel diseases
Multicriteria analysis of the technical, environmental and social factors triggering the PIMBY principle for Wind technologies (WENDY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Spain,Belgium,Norway,Italy,Greece,Denmark
Call: Wind energy in the natural and social environment (HORIZON-CL5-2021-D3-03, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 2999687.5
EU funding (EUR): 2999687.5
Participants: 9
Project status: SIGNED

WENDY aims at unravelling the factors triggering social acceptance of wind farms through an in-depth analysis at three dimensions: social sciences and humanities, environmental sciences and technological engineering. For that, the project will implement a series of local actions promoting the wider adoption of the project solutions, including guidelines, reports and handbooks which will be created to boost the understanding of wind farms decision making processes and enhance energy citizenship. This will be supported by the spatial multi-criteria WENDY toolbox. A tool able to identify the optimal turbines’ siting with the minimum environmental impact and highest social acceptance likelihood. All developed models, methods, guidelines and tools will be implemented within 10 wind projects spread across 4 countries. These have been selected considering: geography (north vs. south Europe), maturity stage (viability phase / planning phase / short-term operation phase / long-term operation phase); type of wind energy (onshore / offshore – floating, fixed-); and co-existence with other activities (agriculture, fisheries, energy communities). In these locations, outreach activities tailored to their specificities will be performed, creating the WENDY Knowledge Hubs which will incorporate citizens, local authorities, business owners and value chain actors of wind energy. WENDY Hubs will serve as a baseline for the WENDY Knowledge Exchange Platform, a forum that will be developed to facilitate the exchange of knowledge between decision makers and key stakeholders within wind farms planning processes. For a successful implementation of the project activities, all the value chain and the best-in-class expertise is involved in the project consortium including 9 partners from 6 European countries: 1 Large Company (EGP), 2 SMEs (WR, Q-PLAN), 1 University (CBS), 2 RTO (CIRCE, NINA), 1 Energy Community (MEC), 2 Non-profit organisations and associations (NOWC, APPA).

Keywords: wind energy,energy community,ssh,wind technology,biodiversity,modeling tools,knowledge hubs,guidelines,models,energy citizenship,enviromental design,energy landscape,onshore,offshore
Single-Clone Multi-omics Sequencing for Cancer Diagnosis (MultiCloneSeq)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-10-01
End date: 2025-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Cancer led to one in six death worlds wildly. By nature, cancer is characterized by abnormal and uncontrolled cellular growth caused primarily by genetic mutations. Despite of the high cellular heterogeneity, only a small number of somatic mutations shown to be directly associated with tumorigenesis, hence driving cancer growth. The first hurdle in the cancer diagnosis is to identify these rare populations that have the potential to develop drug resistance. A second hurdle is to be able to associate mutations in the genetic level to the RNA expression level, which will improve the chance of pinpointing a specific mutation with the relevant activity. Therefore, it is of crucial importance to develop a single-cell multi-omics sequencing tool to simultaneously study the heterogeneity of expression and DNA-based regulation of cancer-associated genes. Recently, several multi-omics tools have emerged that allow for the interrogation of both gene expression and open chromatin regions. However, there are some notable limitations constrain the capability and applicability of these tools: 1) The expensive and disposable apparatuses and reagents of these methods is extremely expensive, and thus limits their extensive application and potential as a diagnosis tool; 2) The transcriptome derived from all these technologies only captures the 3 ' RNA termini of polyadenylated transcripts. It excludes the capture of non-polyadenylated transcripts which plays a vital role in cancer development, and the interrogation of somatic mutation from full length RNA. (3) The low input of single-cell material leads to the sparse data. To overcome these hurdles, our novel technology is based on three methods that we have developed leveraging the power of microfluidics: 1. single-clone sequencing, 2.Full-length RNA, and 3. A cost efffective open chromatin extraction method. MultiCloneSeq will be the first method providing low-cost and full-scale multiomic profiling with high resolution.
Valorisation of iron-rich & Zinc-containing steelmaking by-products via HYdrogen-based ReductiON (ZHYRON)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Clean Steel (co-programmed)
Countries involved: Spain,France,Belgium,Sweden,Germany,Italy
Call: Circular economy solutions for the valorisation of low-quality scrap streams, materials recirculation with high recycling rate, and residue valorisation for long term goal towards zero waste (Clean Steel Partnership) (RIA) (HORIZON-CL4-2023-TWIN-TRANSITION-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 4531761.5
EU funding (EUR): 4531761.5
Participants: 9
Project status: SIGNED

In the coming years, innovative DR shafts and EAFs will be installed in several steelmaking sites across Europe to follow the strategic decarbonization guidelines. The progression of these production processes will imply changes in the composition and management of generated by-products, especially for those containing Zn. Likewise, the large rate of fossil fuels/reductants needed in the current valorisation processes of these wastes make them very intensive in terms of CO2 emissions, requiring the metallurgical industry to move to H2 applications in its targeted pathway towards zero wastes goal. To tackle with these complex challenges and to solve the recycling of key steelmaking by-products like EAF dust, BOF dust and sludges, DR sludge and pellet fines and mill scales (among others), ZHYRON will develop an innovative valorisation route for Fe-rich and Zn-containing by-products based on the combination of pyrometallurgical (using green H2 as reductant) and hydrometallurgical stages The iron oxides units would be recovered as Direct Reduced Iron able to be consumed in EAF and the zinc would be recovered as zinc oxide concentrate to be used in zinc smelting sector, contributing thus to circular economy and industrial symbiosis approaches. The proposed technologies will be developed and endorsed at lab pilot scale (TRL6), and the obtained circular products will be validated by testing and characterization analysis. ZHYRON will also examine solutions regarding technical integration, economic and environmental criteria, contributing to the development of novel business models, guidelines and strategies. ZHYRON has been structured in 6 WP, combining R&D activities, project management and dissemination activities, and gathering a competitive consortium of 9 partners from 6 EU countries. If the solutions are successful, the benefits will include avoiding landfill of dangerous wastes, reduction in the CO2 emissions and the implementation of a new circular economy loop.

Keywords: steelmaking residues valorisation,fe rich and zn containing wastes,h2 thermal reduction,hydrometallurgical zn recovery,steel sector circular economy