Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mechanism and Consequences of the Interplay between Mitosis and Human Papillomavirus Initial Infection (MitoVin)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 1868993.0
EU funding (EUR): 1868993.0
Participants: 1
Project status: CLOSED

Human Papillomavirus Type 16 (HPV16), the paradigm cancer-causing HPV type, is a small, nonenveloped, DNA virus characterized by its complex life cycle coupled to differentiation of squamous epithelia. Due to this complexity, how HPV16 infects cells is an understudied field of research. Our previous work to define the cellular pathways that are hijacked for initial infection revealed uptake by a novel endocytosis mechanism, and the requirement for mitosis for nuclear delivery. Our findings indicated that nuclear envelope breakdown was required to access the nuclear space, and that the virus associated with mitotic chromatin during metaphase. This prolonged mitosis, a process beneficiary for infection. The viral L2 protein as part of incoming viruses mimics this on its own. The aim of this proposal is to reveal how HPV16 differentially modulates or takes advantage of the mitotic machinery for nuclear import in cells, tissues or during aging, and whether malignant cellular consequences arise. On the viral side, we will define the minimal properties of L2 to mediate association with cell chromatin and mitosis prolongation. On the cellular side, we will identify the protein(s) that mediate recruitment, and how it occurs in a detailed temporal/spatial manner. To elucidate the mechanism of mitotic prolongation and consequences thereof, we will identify which regulatory complex of mitosis is targeted, how it is induced, and whether it causes DNA damage or segregation errors. Finally, we will ascertain the influence of tissue differentiation and aging on this process. Using systems biology, proteomics, virology, cell biology, biochemistry, and a wide range of microscopy approaches we will unravel the complex interactions between HPV and the host cell mitosis machinery. In turn, as viruses often serve as valuable tools to study cell function, this work is likely to uncover new insights into how cells spatially and temporally regulate mitosis in differentiation and aging.
Influence-based Decision-making in Uncertain Environments (INFLUENCE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Netherlands,United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-01-31
Duration (months): 60.0
Total project cost (EUR): 1475560.0
EU funding (EUR): 1475560.0
Participants: 2
Project status: CLOSED

Decision-theoretic sequential decision making (SDM) is concerned with endowing an intelligent agent with the capability to choose actions that optimize task performance. SDM techniques have the potential to revolutionize many aspects of society and recent successes, e.g., agents that play Atari games and beat a world champion in the game of Go, have sparked renewed interest in this field. However, despite these successes, fundamental problems of scalability prevents these methods from addressing other problems with hundreds or thousands of state variables. For instance, there is no principled way of computing an optimal or near-optimal traffic light control plan for an intersection that takes into account the current state of traffic in an entire city. I will develop one in this project. To achieve this, I will develop a new class of influence-based SDM methods that overcome scalability issues for such problems by using novel ways of abstraction. Considered from a decentralized system perspective, the intersection’s local problem is manageable, but the influence that the rest of the network exerts on it is complex. The key idea is that by using (deep) machine learning methods, we can learn sufficiently accurate representations of such influence to facilitate near-optimal decisions. This project will construct a theoretical framework for such approximate influence representations and SDM methods that use them. Scalability of these methods will be demonstrated by rigorous empirical evaluation on two simulated challenge domains: traffic lights control in an entire city, and robotic order picking in a large-scale autonomous warehouse. If successful, INFLUENCE will produce a range of influence-based SDM algorithms that can, in a principled manner, deal with a broad range of very large complex problems consisting of hundreds or thousands of variables, thus making an important step towards realizing the promise of autonomous agent technology.
SAFECHILD: Innovative Safety System for Children Transported in Vehicles (SAFECHILD)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Poland
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2017-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The overall objective of the SAFECHILD project is to significantly improve children’s safety when they are transported on private vehicles. SAFECHILD will launch the production and sale of a new SAFECHILD Child Restraint System (CRS) that offers better protection than any other device available in the market. This new safety system meets the applicable UN/ECE Regulations 129 and goes further by setting the basis for a new standard in protecting the youngest passengers. The sequential ambition of the company leading this project (IDAP Technology) is to create a new brand of CRS, to approach car Original Equipment Manufacturers (OEMs) in order they include the new CRS solution in their portfolios of safety systems and, finally, to become main manufacturer of CRS solutions for those third parties. Summarizing, the current SMEs Instrument project will allow to perform appropriated market research and define in detail SAFECHILD Business Plan, to create strong presence on the Internet and to enlarge selling opportunities from the on-line mass market to, for instance, the car OEMs.

Keywords: child restraint system crs,child safety
Innovation Management Support for SMEs (Innosupport)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Germany,Germany,Germany
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 50500.0
EU funding (EUR): 50500.0
Participants: 3
Project status: CLOSED

The general objective of the described actions is to contribute to smart growth in the European Union by increasing the efficiency and effectiveness of investments in research, development and innovation and by contributing to a better and more efficient connection of actors along the innovation chain. To achieve the above mentioned objectives the proposed grant shall: a) Identify bottlenecks to the creation of economic impact in companies benefitting from grants by Horizon2020's SME instrument and address these bottlenecks with the help of capable coaches. This service to beneficiaries of the SME instrument in the context of a giving project is called 'Key account management'. b) Increase the efficiency and effectiveness of innovation processes in small and medium sized enterprises with significant innovation activities that could potentially become beneficiaries of European support to research and innovation but would not have effective access to consulting services for innovation management. This service, provided independently from a specific innovation project and focussing on a company's innovation management system, is called 'Enhancing the innovation management capacity of SMEs'.

Keywords: innovation management
BovReg - Identification of functionally active genomic features relevant to phenotypic diversity and plasticity in cattle (BovReg)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Germany,Australia,Germany,Spain,Germany,Switzerland,Belgium,Finland,Poland,France,France,Netherlands,Netherlands,Denmark,United Kingdom,Portugal,Canada,United Kingdom
Call: Agri-Aqua Labs (H2020-SFS-2018-2, 2018)
Start date: 2019-09-01
End date: 2024-02-29
Duration (months): 54.0
Total project cost (EUR): 6033458.83
EU funding (EUR): 5993458.83
Participants: 21
Project status: SIGNED

Despite the revolution in functional genome analysis a wide gap in understanding associations between the (epi)genome and complex phenotypes of interest currently remains and impedes efficient use of annotated genomes for precision breeding. The BovReg consortium will provide a comprehensive map of functionally active genomic features in cattle and how their (epi)genetic variation in beef and dairy breeds translates into phenotypes. This constitutes key knowledge for biology-driven genomic prediction needed by scientific and industry livestock communities. The BovReg brings together a critical mass of experts in ruminant research and beyond encompassing bioinformatics, molecular and quantitative genetics, animal breeding, reproductive physiology, ethics and social science. Our 20 partners from the EU, Canada and Australia form a global interdisciplinary team, which builds on previous and running national and EU-funded projects and many established industry cooperations. In BovReg we will generate functional genome data based on FAANG core assays from representative bovine tissues and newly established cell lines covering different ontological stages and phenotypes applying novel bioinformatic pipelines. We will establish detailed knowledge on traits related to robustness, health and biological efficiency in cattle. Data, knowledge and protocols will be deposited in European biological archives, aiming to set up and maintain a knowledge hub and establish gold standards. Long-term availability of data and targeted dissemination and communication activities are guaranteed by EMBL-EBI, FAANG and EAAP. Our biology-driven genomic prediction tools will integrate biological knowledge on regulatory genomic variation into genomic selection schemes for local and global cattle populations. This improved knowledge will be useful for re-focussing cattle production, fully taking into account societal awareness, environmental and animal-welfare aspects and bio-efficiency.

Keywords: bovine,genomic features,bioinformatics,quantitative genetics,animal breeding
Unravelling Glycochemistry with Ion Mobility Spectrometry and Gas-Phase Spectroscopy (GlycoSpec)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-08-01
End date: 2025-07-31
Duration (months): 60.0
Total project cost (EUR): 2642850.0
EU funding (EUR): 1705350.0
Participants: 2
Project status: SIGNED

Oligosaccharides or glycans are essential in nature and central participants in virtually every biological process. The extensive structural diversity enables glycans to encode rich information in biological functions; however, it also creates major challenges in almost all aspects of the glycosciences. The synthetic formation of glycosidic bonds during glycan assembly for example, is mechanistically still not fully understood. This is largely a result of highly-reactive, but short-lived oxocarbenium ion intermediates, which are difficult to study using established techniques. However, the structure of these intermediates dictates the stereochemistry of the resulting glycosidic bond, the control of which is absolutely crucial for a successful synthesis. An equally important aspect is the sequencing of glycans, which is generally complicated by the frequent occurrence of isomers. This is further complicated by poorly understood rearrangement reactions during mass spectrometric analysis, which often lead to erroneous structural assignments. Here as well, cationic intermediates are the key species that determine the outcome of the rearrangement. The aim of GlycoSpec is to unravel fundamental aspects of oligosaccharide reaction and fragmentation mechanisms by probing cationic glycan intermediates. To do so, a unique combination of instrument and method development (ion mobility-mass spectrometry and cold-ion spectroscopy), chemical synthesis and theory will be used. The gain in mechanistic understanding will provide the basis to tailor building blocks and reaction conditions and is expected to lead to a major advancement in glycosynthesis. The mechanistic understanding of fragmentation reactions will furthermore lead to general rules for the prediction of tandem mass spectra. Just like in the early years of proteomics, this will make the technology automatable and accessible for broader applications. Therefore, GlycoSpec will help to initiate the pursuit of glycomics.

Keywords: mass spectrometry,ion mobility spectrometry,gas phase spectroscopy,infrared,glycosyl cations,glycomics
LIGHTS in Lincoln – Get Hold of Tech and Science research nights (LIGHTS Nights)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: United Kingdom
Call: European Researchers' Night (H2020-MSCA-NIGHT-2016, 2016)
Start date: 2016-05-01
End date: 2017-12-31
Duration (months): 20.0
Total project cost (EUR): 195878.75
EU funding (EUR): 165349.0
Participants: 1
Project status: CLOSED

The key aim of University of Lincoln (UoL) ‘LI-GHTS’ festival is making research accessible for everyone, expressed in its LIGHTS acroynm (Lincoln – Get Hold of Tech and Science). LIGHTS Nights will serve a huge hinterland of the Midlands and North/North Eastern England with a dispersed, predominantly rural population including some of the most deprived areas of the UK which are home to large numbers of non-UK born EU citizens. Centred in this area, which too often lags behind other parts of Europe socially, economically and educationally, LIGHTS Nights has immense capacity to help realise the untapped potential of its local and regional hinterland by bringing people of all ages and backgrounds closer to the research of UoL through showcasing some of the University’s most exciting and dynamic science, informing them of the amazing science being forged on their doorstep, and inspiring them with the importance, excitement and excellent of our research. The UoL sits in the ancient Roman and medieval city of Lincoln, close to the stunning cathedral which has dominated the surrounding landscape for nearly 1,000 years. In contrast, the UoL was founded barely 20 years ago, but has become the UK’s fastest growing university expanding from nothing in 1995 to more than 13,000 students in 2015 and been ranked among the top 40 UK universities. The UoL’s meteoric growth has not been allowed to sever the it’s connections with its community. As well as working internationally, UoL is firmly embedded within its locale and is thus transforming its host city. The ambitious and upward trajectory of the UoL represents an inspiring model for young people looking to engage with learning and research. As such the opportunity to stage a Researcher’s Night is both timely and very valuable, and has a high potential to deliver a significant dividend in terms of attitudinal shift in wider publics towards the importance and benefits of research and research as a career.

Keywords: inspiring young people,women in science,science and therapy,science and disease,science and learning,science in society,science,history and heritage,science and environment
Models for Lignocellulose Thermochemical Conversion (Mod-L-T)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Ireland
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 1943146.88
EU funding (EUR): 1943146.88
Participants: 1
Project status: SIGNED

Chemicals, fuels and energy must be produced from lignocellulosic plant-matter if global economies are to decarbonise. To be successful, these lignocellulose-derived products must compete in technical quality and price with fossil derived products. Thus, we must understand what lignocellulose is, and how its chemical structures react in thermochemical processing technologies, such as pyrolysis. Pyrolysis is a promising method to produce valuable products from lignocellulose and the basic fundamental process of more complex thermochemical technologies, such as catalysis. Mod-L-T deciphers the elementary reaction mechanism and kinetics of lignocellulose pyrolysis. Relative to cellulose, the reaction kinetics of hemicellulose and lignin are less studied, and thus the focus of Mod-L-T. Mod-L-T creates the first detailed, elementary, mass- and energy-conserved chemical reaction model for lignocellulose pyrolysis. A compositional characterisation and modelling procedure utilising Nuclear Magnetic Resonance spectroscopy identifies what molecular structures comprise, and best represent actual lignocelluloses. The mechanism and kinetics of the pyrolysis reaction of the identified hemicellulose and lignin functionalities are then rigorously and systematically determined by the study of model molecules of incrementally increasing structural complexity, up to actual hemicellulose and lignin structures. Experimental and theoretical means are coordinated; A Thin Film Reactor obtains kinetically limited isothermal reaction rate and time-resolved evolved species information. Potential Energy Surfaces are determined by the M06-2X/6-311++G(d, p) methodology. This new fundamental knowledge is assimilated by the construction of detailed reaction kinetic models for hemicellulose, lignin and lignocellulose pyrolysis. The knowledge is disseminated for application in optimized and reduced models, envisaging their coupling to process and fluid dynamic engineering modelling tools.

Keywords: chemical reaction kinetics,kinetic model,lignocellulose,pyrolysis,lignin,hemicellulose
Prevalence and Experience of Diagnostic Shifts in Youth Mental Healthcare (PAEDS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

Epidemiological data shows that psychiatric diagnoses in childhood have limited temporal continuity. Over the course of a child’s contact with mental health services, a diagnosis received at one time can transition into a different diagnostic classification or be lost entirely. Such shifts can have profound implications for young people and their families, given the significance invested in diagnostic labels as a means of making sense of emotional and behavioural difficulties. However, no research has investigated the prevalence of diagnostic shift in Child & Adolescent Mental Health Services (CAMHS) or explored how it is experienced by the children and families affected. PAEDS aims to provide the first such evidence through a two-stage mixed-methods design. First, a review of clinical records in an Irish CAMHS service will establish the frequency with which diagnostic shifts occur and the typical patterns through which they manifest. Second, qualitative interviews will be conducted with children and parents who have experienced diagnostic shift, to establish the narratives through which people make sense of these changes and the implications for self-concept, social identity and service engagement. To exploit the social and clinical value of the results, a Delphi process will be initiated that engages a diverse panel of stakeholders in developing evidence-based resources that help service-providers and service-users adapt to diagnostic shift. The project will thereby promote sensitive, patient-centred youth mental health policy and practice. It will also provide a platform for me to build a career pioneering the interdisciplinary study of how scientific and clinical classifications interact with identity. By fully integrating a tailored Personal Career Development Plan into the action programme, I will capitalise on the MSCA’s opportunity for the strategic development of skills and competencies valued in the current academic environment.

Keywords: psychiatric diagnosis,youth mental health,mixed methods,case note review,qualitative interviews