Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High Content Microanalytical Ramanomics for Ultraquantitative Phenotyping of Individual Stem Cells and Bioengineered Organoids (UltraRamanomics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Human induced pluripotent stem (hiPS) cell-based organoids have recently emerged as a promising model system to recapitulate the structure and function of actual biological tissues and organs. These 3D self-organized multi-cellular tissue systems bridge the gap from cell to tissue/organ levels, providing bio-relevant model systems with foreseeable utility in drug discovery, regenerative medicine, and the study of disease pathogenesis, but the increased complexity and unique attributes of each system introduces new challenges in cell culture and experimental reproducibility. While organoids offer profound potential for applications in biological and biomedical research, their scientific value is limited by how closely they mimic the in vivo tissue systems they are intended to model. To achieve a successful organoid-based predictive model system, it is crucial to have a quantitative biochemical and structural analysis technique for single cells and organoids. In UltraRamanomics, I will develop a robust quantitatively-calibrated bioanalytical platform for high content phenotypic profiling of individual stem cells and hiPS cell-derived organoids, to allow direct structural and quantitative compositional comparison of organoid models in absolute biochemical measurements, thereby addressing the currently unmet analytical need. The platform will be based on micro-Raman spectroscopy – enabling direct measurements of the absolute biochemical composition of single-cells and tissue organoids with unprecedented spatial resolution – to provide a novel analytical solution to the existing gap in stem cell organoid research. This proposal takes full advantage of recent advances in ultraquantitative micro-calibration technology I developed during my PhD, quantitative volumetric Raman imaging (qVRI) methodology developed by the Stevens Group, and the organoid-on-a-chip platform in development at the Centre of Excellence Hybrid Technology Hub with the Krauss Group (Secondment).

Keywords: organoids,stem cells,drug screening,raman microscopy,raman imaging,quantitative analysis
COMFort in the cabin DEMOnstrator (ComfDemo)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Germany,Netherlands,United Kingdom
Call: Evaluation and modelling of comfort driving parameters in a Cabin Demonstrator (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-08-01
End date: 2022-12-31
Duration (months): 41.0
Total project cost (EUR): 1191738.75
EU funding (EUR): 1191738.75
Participants: 4
Project status: CLOSED

In this proposal, a demonstrator of an aircraft interior is made in which experiments with real humans can be done to understand and optimize air passengers’ comfort perception. The demonstrator will be able to simulate turboprop airplanes, which have additional complexity due to their unique vibro-acoustic properties. Worldwide, approximately half of air travel is composed of short-range flights, for which turboprop aircraft are demonstrably better suited. They produce less CO2 emissions and are more efficient than jet aircraft. However, cabin noise and vibration is relatively higher in comparison to jet aircraft, lowering the perception of comfort and predisposing passengers to choose jet aircraft. In this proposal, a demonstrator is built in which passengers experience an aircraft interior in which various parameters influencing comfort can be varied to study improvements to the overall in-flight comfort. An initial comfort model is made based on the literature and then updated based on real flights. In these flights, participants complete questionnaires and wear a jacket, which will record data on sound, vibration, temperature, and pressure. The questionnaires contain questions on the perception of 1) physical ergonomics; 2) vibration; 3) acoustics; 4) spatial-psychological; 5) visual-light; 6) air quality; 7) smell; 8) temperature; and 9) temporal (time) requirements and related comfort sensation. In addition, some environmental conditions and psychophysiological reactions will be monitored. A protocol is made to study passengers in the demonstrator, aiming to solve the comfort issue. While applicable to all airplanes, the goal is to study noise and vibration of turboprops, which requires installing equipment like speakers and vibration actuators under seats. By studying comfort-influencing factors on passengers, various aircraft interiors can be tested before the real plane is built, and aspects influencing comfort can be optimized.

Keywords: comfort model,real flights,jacket,environmental conditions and psychophysiological reaction monitoring
Arrowhead Tools for Engineering of Digitalisation Solutions (Arrowhead Tools)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Austria,Germany,Germany,Germany,Spain,Spain,Italy,Italy,Italy,Italy,Italy,Austria,Germany,Germany,Germany,Germany,Italy,Italy,Austria,Austria,Germany,Germany,Germany,Austria,Finland,Norway,Norway,Hungary,Poland,Türkiye,Finland,Sweden,Sweden,Sweden,Switzerland,Norway,Belgium,Romania,Romania,Sweden,Latvia,France,France,France,France,France,Czechia,Czechia,Netherlands,Netherlands,Netherlands,Portugal
Call: ECSEL-2018-1-IA (H2020-ECSEL-2018-1-IA-two-stage, 2018)
Start date: 2019-05-01
End date: 2022-07-31
Duration (months): 39.0
Total project cost (EUR): 83757196.26
EU funding (EUR): 21154991.47
Participants: 94
Project status: SIGNED

For the purpose of creating digitalisation and automation solutions Arrowhead Tools adresses engineering methodologies and suitable integrated tool chains. With the global aim of substantial reduction of the engineering costs for digitalisation/automation solutions. Thus the Arrowhead Tools vision is: - Engineering processes and tool chains for cost efficient developments of digitalization, connectivity and automation systems solutions in various fields of application For the further and wider commercialisation of automation and digitalisation services and products based on SOA, Arrowhead Framework and similar technologies there is a clear need for engineerings tools that integrates existing automation and digitalisation engineering procedures and tool with SOA based automation/digitalisation technology. For this purpose the Arrowhead Tool’s grand challenges are defined as: - Engineering costs reduction by 40-60% for a wide range of automation/digitalisation solutions. - Tools chains for digitalisation and automation engineering and management, adapted to: 1. existing automation and digitalisation engineering methodologies and tools 2. new IoT and SoS automation and digitalisation engineering and management tools 3. security management tools - Training material and kits for professional engineers The results will create impact on: - Automation and digitalisation solution market - Automation and engineering efficiency and the SSBS market - Automation and digitalisation security - Competence development on engineering of automation and digitalisation solution

Keywords: engineering of digitalisation solutions
Dis-inhibitory circuits in the human cerebral cortex (INHIBITHUMAN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Denmark,United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-12-01
End date: 2022-11-30
Duration (months): 72.0
Total project cost (EUR): 2499913.0
EU funding (EUR): 1796038.0
Participants: 2
Project status: SIGNED

Temporal co-ordination of the activity of cortical neurons underlies cognitive processes. Intracortical inhibitory circuits set temporal windows for modulation of glutamatergic pyramidal cell firing. In non-human mammals, the activity of the GABAergic neurons is governed by other specialised GABAergic neurons, which can dis-inhibit pyramidal cells. The overarching aim of this project is to define cellular and pharmacological mechanisms of dis-inhibitory circuits in the human cerebral cortex. These circuits could act as regulators of cognitive process. First, we will investigate the neuron types and their synaptic influences to characterise how dis-inhibition controls synaptic integration and the output of neurons. Second, we will elucidate synaptic plasticity in dis-inhibitory circuits, as plastic events likely represent physiological substrates of cognitive operations. Third, we will identify the subcellular sites and the mechanisms of action of key receptors for ACh, monoamines, endocannabinoids, neuropeptides and mGluRs modulating dis-inhibitory circuits, which are targets of small molecule CNS drugs, such as cognitive enhancers. We will test three hypotheses: 1) the human cortical pyramidal cell output is gated by compartment-specific dis-inhibition mediated by specific interneurons; 2) activity-dependent plasticity occurs in dis-inhibitory circuits and has consequences for the output of cortical pyramidal neurons; 3) small molecule drugs act via dis-inhibitory mechanisms at cell-type specific sites altering the inhibitory dynamics of pyramidal cells leading to subcellular redistribution of inhibition and alteration in their output. Combined electrophysiology/imaging with neuropharmacology and high resolution molecular receptor localisation will generate an unprecedented knowledge of the human cortical circuits. Understanding human cortical neuronal connections and their responses to pharmacological interventions may also lead to novel therapeutic strategies.

Keywords: interneuron,gaba,cerebral cortex,electrophysiology,synaptic transmission,synaptic receptors
Market Surveillance Action for Tyres 2015 (MSTYR15)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Germany,Spain,Estonia,Ireland,Türkiye,Belgium,Bulgaria,Finland,Croatia,Lithuania,Poland,Romania,Sweden,Latvia,Netherlands,Luxembourg
Call: Ensuring effective implementation of EU product efficiency legislation (H2020-EE-2015-3-MarketUptake, 2015)
Start date: 2016-03-01
End date: 2018-06-30
Duration (months): 28.0
Total project cost (EUR): 1854673.7
EU funding (EUR): 1854672.95
Participants: 19
Project status: CLOSED

MSTyr15 (Market Surveillance Action TYRes 2015) will help deliver the economic and environmental benefits of Regulation (EC) No. 1222/2009 on the labelling of tyres with respect to fuel efficiency. It will achieve this by: • Coordinating the monitoring, verification and enforcement activities of 13 Market Surveillance Authorities (MSAs) across the Single Market and Turkey; • Improving the effectiveness of the MSAs through skills-building training, the provision of guidelines and the promotion of Best Practices. MSTyr15 will enhance the functioning of the European Single Market by ensuring that the tyres regulatory measures are effectively enforced across MS. It will deliver energy savings >105 GWh/year through removing incorrectly labelled tyres from the market. Experience and resources for enforcement have been very limited in many MS since the tyres regulations were introduced in 2009. MSTyr15 includes mechanisms for assisting the skills development of less experienced staff and their authorities, supporting the adoption of common best practices and providing budgets to cover the high costs of testing tyres to the required standards. It will coordinate market surveillance actions involving checks on in excess of 15,000 tyres. It will deliver a higher level of surveillance activities that go beyond testing. The consortium will work closely with other non-participating MSAs across the EEA though its liaison with the Tyres ADCO. Additionally, the MSTyr15 consortium will work together with an Advisory Board comprising of supply-side business, consumer organisations and environmental NGOs. The expected results are: - Adoption of best practices; - Market surveillance being undertaken in a more cost effective and consistent manner; - Increased awareness of and respect for market surveillance by tyres suppliers and users; - Effective enforcement of EC Regulation on the labelling of tyres resulting in substantial energy savings expected to be better than 105 GWh/year.

Keywords: tyres
Supporting Sustainable Energy Production from Biomass from Landscape Conservation and Maintenance Work (greenGain)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Spain,Germany,Italy,Spain,Germany,Italy,Germany,Czechia
Call: Market uptake of existing and emerging sustainable bioenergy (H2020-LCE-2014-3, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 1829390.5
EU funding (EUR): 1829390.5
Participants: 10
Project status: CLOSED

The aim of greenGain is to strengthen the energy use of regional and local biomass from the maintenance of areas and landscape elements, which is performed in the public interest. The scope of the biomass used, will be any material predominantly produced from nature conservation and landscape management, but not from energy-crops. The main target groups are regional and local players, who are responsible for maintenance and conservation work and for the biomass residue management in their regions. Moreover, the focus will be on service providers - including farmers and forest owners, their associations, NGOs and energy providers and consumers. The project will show strategies to build up reliable knowledge on local availability of these feedstocks and know-how on issues from logistics to storage and sustainable conversion pathways for the transformation of these feedstocks to renewable energy (heat and energy products). Furthermore political, legal and environmental aspects will be addressed in model regions. Awareness raising, governance and public acceptance actions will be focussed on. General guidelines will be prepared to guarantee a wide dissemination to other regions in the EU. The regional partners will be actively supported by Technical Partners for the project measures’ development and implementation. As a CSA, the project focal point will be the exchange between the model regions and other similar relevant players in the EU, by good practice exchange, a topic-specific website, several workshops and educational site visits in different regions as well as other standard public relations activities. The project team is carefully balanced between technical and scientific organisations and local demand side oriented players. Regions in northern Europe with a wide knowledge in this field are cooperating with European (south-west, middle, east) regions, having an untapped potential, that can be accessed through efficient knowledge transfer.

Keywords: stakeholder network,landscape conservation feedstock,residues,roadside vegetation,harvest,logistic,intermediates,conversion,database,governance,awareness raising,cap building
Analysis, Design and Experimental Evolution of Novel Carbon Fixation Pathways (NOVCARBFIX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-01-01
End date: 2020-12-31
Duration (months): 60.0
Total project cost (EUR): 1999843.0
EU funding (EUR): 1999843.0
Participants: 1
Project status: CLOSED

Carbon fixation is a prerequisite for accumulating biomass and storing energy in most of the living world. As such, it supplies our food and dominates land and water usage by humanity. In agriculture, where water and nutrients are abundant, the rate of carbon fixation often limits growth rate. Therefore increasing the rate of carbon fixation is of global importance towards agricultural and energetic sustainability. What are the limits on the possible rate of carbon fixation? Attempts to improve RuBisCO, the key enzyme in the Calvin-Benson cycle, have achieved only limited results. My lab focuses on trying to overcome this global challenge by building synthetic pathways for carbon fixation. We create a computational framework that designs and scores pathways and creates step-wise selection strategies for in-vivo experimental implementation. Our most promising synthetic carbon fixation pathways are found to utilize the highly effective carboxylating enzyme, PEP carboxylase. We experimentally test these pathways in the most genetically tractable context by constructing an E.coli strain that depends on atmospheric CO2 fixation. We will gradually incorporate the pathways, initially as essential reaction steps for biomass production, and finally with CO2 as sole carbon input of the cell. As a stepping-stone towards this challenging goal, we will construct an autotrophic E.coli strain that uses the Calvin-Benson cycle. We systematically convert this synthetic biology grand challenge into a gradual evolutionary ladder with independently selectable steps. We recently achieved key steps in the ladder, such as semi-autotrophic growth, serving as powerful proofs of concept. The proposed research will advance our basic-science understanding of evolutionary plasticity of metabolic pathways. It also paves the way for a hybrid rational-design/experimental-evolution approach to revisit and advance the capacity of metabolism for agricultural productivity and renewable energy storage.

Keywords: carbon fixation cycles,metabolic pathways
GRAvitational waves from Neutron stars: Investigating Transient Emission (GRANITE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

In this research project we will perform the first search for a promising new type of gravitational-wave signal from neutron stars: medium-duration transients (MDTs). We will use data of unprecedented sensitivity from the new detectors Advanced LIGO and Advanced Virgo. A successful detection will provide a novel test of gravity and unique insights into the structure of neutron stars. Gravitational waves (GWs) were predicted by Einstein a century ago, but are extremely hard to detect. Their first direct observation will herald the start of a new era in astronomy but requires specialised searches to extract the full astrophysical information about each source. Much effort already goes into the search for continuous waves (CWs) emitted by rotating neutron stars (NSs) with non-axisymmetric deformations, which should be observable over many years. Only very weak CWs are expected, but NSs can also emit relatively strong transient GWs on much shorter timescales. In this fellowship we will develop and implement the first practical search for signals spanning these extremes, bridging the gap between continuous and transient phenomena. Based on an explicit CW-like signal model, limited in duration, and on a Bayesian model selection approach, we will first construct an optimal detection method for medium-duration transient (MDT) signals taking into account astrophysical priors on transient GW emission from rotating NSs. Second, we will use synergies with established CW data-analysis methods to guarantee an efficient implementation and build on previous experience to account for complex detector noise properties. We will then apply these newly-developed methods to the best advanced-detector data available. This novel CW-based transient search will be the first to provide the ability to detect NSs as MDT sources, to estimate their astrophysical parameters with high precision, and to infer their internal properties which are inaccessible through other observational methods.

Keywords: gravitational waves,neutron stars,data analysis,bayesian statistics,continuous waves,pulsars
Ubiquitin-dependent regulation of the microtubule cytoskeleton (UBIMAPS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-11-01
End date: 2020-03-02
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The microtubule cytoskeleton is a dynamic array of cylindrical polymers that play important roles in various cellular processes including chromosome segregation and ciliogenesis. Hundreds of accessory factors – grouped under the term microtubule-associated proteins (MAPs) – orchestrate this network by governing the interaction profile and growth behaviour of microtubules. Due to this critical function, the precise abundance and distribution of MAPs within cells is of high importance and their deregulation is associated with various human diseases, such as ciliopathies and cancer. Surprisingly little is known about mechanisms involved in the regulation of MAPs and so far only a few of them have been identified as targets of the major proteolytic control machinery in cells, i.e. ubiquitin-proteasome system. In this work, I will further explore how MAPs are regulated by ubiquitin-dependent degradation by focussing on a multi-subunit ubiquitin E3 ligase called SCFFbxw5 that seems to play an important role in microtubule control according to preceding experiments of the host lab. Hence, I will investigate in detail two MAPs that were identified as substrates of SCFFbxw5 by the host lab in order to unravel the functional, temporal, and spatial characteristics of their ubiquitylation by SCFFbxw5. Since these MAPs are known to fulfil crucial functions in ciliogenesis and chromosome segregation, this work will promote our knowledge about how ubiquitin-dependent degradation contributes to these processes and may open up novel therapeutic strategies with the associated diseases.

Keywords: microtubules,spindle,microtubule associated proteins,ubiquitin,f box protein,fbxw5,centrosome,cilium,mitosis,chromosome segregation