Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Pi-Conjugated Porphyrin Nanorings (NANORING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-03-01
End date: 2012-02-29
Duration (months): 12.0
Total project cost (EUR): 200049.6
EU funding (EUR): 200049.6
Participants: 1
Project status: CLOSED

This project will explore the synthesis and properties of fully pi-conjugated molecular nanorings with diameters of 3-5 nm. These covalent rings of molecular wire will be constructed from porphyrin and alkyne units, via non-covalent supramolecular assembly on wheel-shaped templates. Their highly delocalized electronic structures are expected to result in unusual optical and magnetic behavior. The photophysical and light-harvesting behavior of the nanorings are expected to mimic natural light-harvesting photosynthetic chlorophyll arrays. Physicists have long been fascinated by the persistent ring-currents and quantized magnetization observed in small loops of wire; it is important to discover whether similar effects can be observed in molecular nanorings. The synthesis of these wire rings could herald the development of molecular solenoids and induction coils with unusual optical and magnetic characteristics, leading to applications in nanoelectronics and nonlinear optics. This project will extend the researcher's experience of organic synthesis, large delocalized chromophores and near-infrared dyes, while introducing him to the latest developments in template-directed synthesis, ESR spectroscopy and ultra-fast photophysics through established collaborations involving the host research group.

Keywords: physical sciences,chemistry,organic chemistry
The rise and fall of military honour in Western Europe, 1789-1918 (EMH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-05-01
End date: 2013-10-31
Duration (months): 24.0
Total project cost (EUR): 170401.6
EU funding (EUR): 170401.6
Participants: 1
Project status: CLOSED

The proposed project examines changing concepts of military honour in Western Europe between the end of the ancien régime culture of civility in the mid-eighteenth century and the advent of modern mass warfare in 1914/18. This period, as a is well known, marked an important political, economic, technological, and cultural watershed in European history. The ancillary transformation of normative codes of conduct in war on the other hand shows historiographical lacunae. Whereas a substantive corpus of literature has been written on the operationalisation of honour within nation-states, we know less about its transnational articulation from a longue durée perspective. The practice of parole d’honneur, which granted captured officers freedom of movement within or en route to their place of confinement in exchange for the promise not to escape, is a case in point. For long both sides imposed heavy social sanctions on non-conformists, but in the Napoleonic Wars and even more so the First World War there occurred partial breakdown of these practices, despite their codification in the Hague Conventions of 1899 and 1907. To address the complex reasons for the reconfiguration of military honour, my projects will develop an interdisciplinary analytical framework which draws on methodologies from history, sociology, and international relations.

Keywords: humanities,history,modern history,political history
Age related changes in strigolactone control of adventitious root initiation (ADVROOTAGESTRIG2010)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-04-01
End date: 2013-03-31
Duration (months): 24.0
Total project cost (EUR): 165800.0
EU funding (EUR): 165800.0
Participants: 1
Project status: CLOSED

Strigolactones are a newly identified (2008) group of plant hormones known to control bud outgrowth. Recently the applicant has discovered that strigolactones also inhibit the formation of roots from non-root tissues (adventitious roots), defining a new role for strigolactones in plants. Adventitious root formation is central for clonal propagation of elite plants and requires the dedifferentiation of stem tissues followed by controlled cell divisions. Plant hormones including auxin regulate adventitious root formation and physiological properties such as age of the explants also determine root induction success. However, the interaction between ageing and plant hormones is poorly understood. Preliminary evidence for age-related variation in strigolactone control of adventitious root formation suggests that the physiological conditions restricting adventitious rooting are likely mediated through a strigolactone signalling mechanism. This project will characterize age-related variation in the strigolactone control of adventitious rooting. Explants from different developmental stages of Poplar and strigolactone mutants of Pea and Arabidopsis will be examined for adventitious rooting phenotypes and response to strigolactone. The project will also investigate interactions with the rooting promoter auxin particularly in relation to the newly identified ARF6, ARF8 and ARF17 regulatory pathway for adventitious rooting developed by Prof. Bellini. This project will facilitate exchange of expertise between the strigolactone lab of Assoc. Prof. Beveridge (Australia), the auxin regulation of adventitious roots (Prof. Bellini, Sweden), the lateral root lab of Prof. Beeckman (Belgium) and the host lab of Prof. Geelen (Belgium) focusing on adventitious rooting and tissue culture.

Keywords: cell biology,sylviculture,plant development,plant propagation,in vitro culture of plant material,plant hormone physiology,cell differentiation
Conceptual processes with and without sensorimotor experience: what is gained and what is missed? (ACTICO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2011-09-01
End date: 2014-08-31
Duration (months): 36.0
Total project cost (EUR): 230084.8
EU funding (EUR): 230084.8
Participants: 1
Project status: CLOSED

Evidence of activation of sensorimotor circuits for action and perception during cognitive tasks, such as language understanding, has been used to challenge the “Cartesian” conception that mind and body are different entities to be studied as separate domains. However, the study of brain-damaged patients has shown that the integrity of sensorimotor processes is not necessary for language. Why would, then, there be activation of the sensorimotor system during language if that activation is not causally involved in the task? To explore this issue, we will investigate how motor processes relate to the language network in the brain, and what information is conveyed by motor processes in language. We will use trancranial magnetic stimulation (TMS) to assess whether motor activity is temporally subsequent and causally determined by activity of language-processing areas, or is independent of it. We will use functional magnetic resonance imaging (fMRI) to investigate activation patterns in the sensorimotor circuits of individuals with congenital deprivation of sensorimotor experience (i.e., amelics) during action-word comprehension, to define how action words are represented in the brain in the absence of sensorimotor experience. The conceptual design of this project takes advantage of the study of a special population, that has not been studied before in this field, and of modern techniques of analysis, such as fMRI and TMS. It has the potential to create a new line of research by establishing a bridge between different cognitive domains, and to impact conceptions in education and re-education by clarifying what sensorimotor experience adds to our conceptual ability and what is missed when it is lacking. Harvard University and CIMeC, University of Trento, will provide the ideal intellectual and technical environments to develop this project and improve significantly the scientific experience of the fellow for a successful career.

Keywords: cognitive neuroscience,experimental psychology,language,semantics,sensorimotor processes,conceptual impairment,neuroimaging,transcranial magnetic stimulation,brain organization
Rapid and Reliable Detection of Foodborne Pathogens by Employing Multiplexing Biosensor Technology (PATHFINDER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-08-01
End date: 2013-07-31
Duration (months): 24.0
Total project cost (EUR): 271636.8
EU funding (EUR): 271636.8
Participants: 1
Project status: CLOSED

Pathfinder is an important research project focused on development of innovative means of detecting important pathogenic organisms associated with food poisoning. This will be achieved using biosensor technology capable of detecting many different pathogens simultaneously. To achieve the main goal the Marie Curie Fellow, Dr. Nitsara Karoonuthaisiri from Thailand will bring her skills in microarrays and pathogen detection and lead a team of scientists at the Host Institute at Queen’s University Belfast. The Fellow will work closely with the Institute Director, Professor Chris Elliott, an eminent European researcher in the field of advanced diagnostics on this two year project at the host institution followed by one year return phase. The outcomes of this research will be extremely important to Europe as food poisoning affects many millions of citizens each year and improved diagnostics has been identified as one of the key topics requiring more research activity. Dr. Karoonuthaisiri has been motivated to apply for this prestigious Fellowship to work in a European centre of excellence to enable transfer of her skills & knowledge to an EU research team.

Keywords: food biotechnology,food products
Methodological development of phytolith analysis for studying non-dietary crop products in prehistoric agricultural societies. (PHYTORES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-06-01
End date: 2013-05-31
Duration (months): 24.0
Total project cost (EUR): 166565.6
EU funding (EUR): 166565.6
Participants: 1
Project status: CLOSED

Plants have been of economic importance since the start of human evolution. Archaeobotanical studies of past agricultural societies have mainly focused on crop domestication and cultivation, both related to food production. However, particularly cereal crops supply not only food but also so-called secondary products (straw, chaff, etc.). Ethnographic studies indicate that these non-dietary resources must have been of fundamental importance in the past, supplying fuel, animal fodder and components for construction material, to cite but a few examples. Proper identification and study of these resources in archaeological studies is crucial for a full understanding of past economies and social organization. However, current analyses focusing on plant macroremains tend to overlook secondary crop products mostly because of preservation biases of these more fragile remains. An excellent opportunity to ensure that secondary resources are no longer forgotten is given by the relatively new research area of phytolith studies. Phytoliths are microscopic, mineral plant particles that preserve under a wide range of environmental conditions, can be identified at different taxonomic levels and enable anatomical plant part identification. The aim of the proposed research is to develop a new methodological framework based on phytolith analysis for the study of non-dietary products originating from Eurasian cereals. The first objective is to systematically develop the identification of Eurasian cereal crops and their different anatomical parts by the study of phytoliths from recent plant material. The second objective is to assess the level of confidence with which the developed identification methodology can be applied to archaeological samples from different contexts (archaeological pilot study). It is expected that the results will represent a substantial development in phytolith analyses and will provide a better understanding of European and Asian history and past economy.

Keywords: archaeology,archaeobotany,phytolith analysis,methodology,morphology,morphometry,prehistoric economy,non-dietary resources,eurasian crop plants,taphonomy.
Cross-cultural misunderstandings of conflict avoidance: A multi-method test of the roles of attributions and communication enhancement (CONFLICT AVOIDANCE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-08-01
End date: 2013-10-03
Duration (months): 24.0
Total project cost (EUR): 192923.2
EU funding (EUR): 192923.2
Participants: 1
Project status: CLOSED

Cross-cultural interpretations of conflict avoidance have not been examined previously but have important implications for global organizations. Furthermore, in some cultures, avoidance is viewed as a negative coping strategy in terms of negotiation and conflict management, whereas in other cultures, it is seen as a positive strategy. Thus, I propose to examine three specific research objectives, namely (1) Understanding cross-cultural interpretations of and attributions made for avoidance behavior; (2) Examining the relationship between attributions for avoidance and outcomes in the context of negotiation; (3) Testing an intervention aimed at improving cross-cultural understanding of avoidance. Specifically, I propose to test hypotheses about how avoidant behavior is interpreted during a cross-cultural negotiation between Jewish and Arab Israelis. Attributions for avoidance are hypothesized to be correlated with outcomes, and information sharing is hypothesized to mediate the relationship between attributions and outcomes. Research questions will first be explored during qualitative interviews with Arab and Jewish Israeli managers in Israel, and hypotheses will subsequently be tested in an experimental study. Given the differences between Arab and Jewish cultural norms for avoidance, Israel provides an excellent laboratory for examining how avoidance of conflict is interpreted (or misinterpreted) cross-culturally. The proposed research also has direct implications for the EU mission of transfer of knowledge, and is in line with the EU’s goals for greater political and economic integration within the EU, between the EU and its neighbors, and throughout the Middle East.

Keywords: organization psychology,industrial psychology
A comprehensive framework for high-resolution assessment and short-term forecasting of the solar resource for renewable energy applications (SOLFORRENEW)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2011-10-03
End date: 2014-10-02
Duration (months): 36.0
Total project cost (EUR): 212869.6
EU funding (EUR): 212869.6
Participants: 1
Project status: CLOSED

The foreseen depletion of the fossil resources is forcing us to seek for new energy springs but the everyday issue of the climate change claims for non-pollutant solutions. In addition, it is expected that the demand for electricity will strongly increase between 2006 and 2030. Therefore, it is unavoidable the transition to more and more renewable energy shares. In this scenario, solar and wind energy are probably the only energy solutions that are acceptable enough to sustain the planet’s long term requirements. However, as solar and wind energies are strongly dependent on highly variable weather, increased penetration rates will lead to strong fluctuations in the electricity grid. Therefore, renewable energies cannot guarantee the amount of energy which is requested by the users and secondary support energy sources are required. Consequently, accurate assessments and forecasts of the resources are pivotal for optimal sitting of the facilities and improved planning and operating decisions. In this proposal we address the development of the methods for assessing and forecasting the solar resource using Numerical Weather Prediction models, the current state of the art in weather modelling. The outgoing phase will be conducted at the National Center for Atmospheric Research (NCAR) of the USA, one of the foremost centers in weather modelling. The fellow will acquire high-quality research training, NCAR’s work methodologies, organization, transfer of knowledge and synergy with university and private sector. Reintegration will increase the perspectives available on this topic in the EU and the experience will be used in future management positions of the fellow. This project will help to promote the solar production in Europe and to increase its penetration in the electricity grid. This proposal will help to meet the increasing demand of electricity, to decrease the emission of greenhouse gases, and also to overcome the dependency of energy imports from outside Europe.

Keywords: solar resource,solar forecast,renewable energies,atmospheric modelling,numerical weather prediction model,environmental physics,remote sensing,energy environmental impact,sustainable policies
Structure and function of γ-secretase studied by single particle cryo-electron microscopy (ΓSECRETASE STRUCTURE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-01-10
End date: 2014-01-09
Duration (months): 24.0
Total project cost (EUR): 173000.0
EU funding (EUR): 173000.0
Participants: 1
Project status: CLOSED

The γ-secretase intramembrane protease complex plays a critical role in multiple cellular processes including Notch signaling and secretion of amyloid β peptides, the accumulation of which causes Alzheimer’s disease (AD). The enzymatic activity of γ-secretase is, therefore, a prime target for intervention in AD and is of major interest. Yet, despite the detailed knowledge of γ-secretase's function in various cellular processes and disease, structural information regarding the complex is extremely limited and its mechanism of action at the molecular level remains poorly understood. We propose to address this challenge by structurally analyzing γ-secretase and its unique mechanism using single particle cryo-electron microscopy (cryo-EM) as a primary tool. While structural approaches, such as X-ray crystallography, struggle in the study of membrane-embedded complexes in general and in the study of γ-secretase in particular, an initial structure has already been produced using single particle cryo-EM, demonstrating the feasibility of the procedure and its great potential. The host laboratory of Prof. Bart De Strooper is well established in the γ-secretase field, while the applicant, Dr. Nadav Elad, is highly experienced in single particle cryo-EM. Combining our expertise, research will aim at achieving a high-resolution structure in close-to-native conditions, determining subunit arrangement and characterizing functional states of γ-secretase. The proposed project both addresses fundamental biological questions regarding intramembrane proteolysis and has immediate therapeutic implications for AD. Additionally, the project will serve as a platform for future studies of γ-secretase, since numerous unanswered questions regarding its variable composition, interactions with multiple substrates and modulators, and its functional mutations, require structural-functional analysis.

Keywords: neurosciences,degenerative diseases,?-secretase,alzheimer?s disease,intramembrane-cleaving protease,single particle cryo-electron microscopy,health sciences
In Vitro and in Vivo Screens for Novel Regulators in Leukemia (NOREL) (NOREL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-04-01
End date: 2014-03-31
Duration (months): 24.0
Total project cost (EUR): 219590.4
EU funding (EUR): 219590.4
Participants: 1
Project status: CLOSED

Leukemic cells, similar to other types of cancer cells, are characterized by aberrant epigenetic changes, which often lead to abnormal expression of oncogenes and tumor suppressor genes. The goal of this project is to identify and characterize new regulators of normal and malignant hematopoiesis. We propose two complementary loss-of-function screens, using shRNA vectors against two groups of histone modifying enzymes, histone methyltransferases and histone demethylases. We plan to perform an in vitro shRNA screen, infecting mouse primary cells with lentiviruses based on single pLKO.1 vectors. We will assess the effect of down-regulation of a specific protein by flow cytometry analysis. In parallel, we will carry out an in vivo shRNA screen in a mouse model of human acute myeloid leukemia (AML). Mouse leukemic cells will be infected with a pooled retroviral shRNA library and transplanted into a small number of recipient mice. When the recipient mice develop AML, the leukemic cells will be harvested and high-throughput sequencing of shRNAs will be used to determine shRNAs depleted or enriched during initiation and progression of AML. Selected candidate genes will be validated and further characterized using in vitro and in vivo assays. Moreover, we will search for molecular mechanisms mediating the function of validated candidates in normal hematopoiesis and/or leukemia. I strongly believe that this project can lead to a discovery of novel oncogenes and/or tumor suppressors involved in AML, and potentially also to design of novel therapies for leukemia treatment.

Keywords: cancer,leukemia,hematopoiesis,shrna,epigenetics