Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cryo-ET of Alphavirus Replication Complex (CryoARC) (CryoARC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: SIGNED

Positive-sense single-stranded RNA (+ssRNA) viruses replicate their genomes in membrane-bound, virus-induced replication complexes (RCs). A major genus of +ssRNA viruses are the Alphaviruses (family Togaviridae). Alphaviruses contain several mosquito-borne viruses that cause substantial human disease burden in tropical and subtropical regions, e.g., Semliki Forest Virus (SFV) and Chikungunya Virus (CHIKV). Alphavirus RCs (also referred to as “spherules”) are outward-facing, balloon-shaped plasma membrane buds of 50-80nm diameter. Our structural understanding of spherules is still fragmental and there is no complete 3D macromolecular architecture of these megadalton complexes. The proposed CryoARC project is based on extensive cryo-electron tomography (cryo-ET), proteomics and structural bioinformatics approaches to explore and resolve the in situ 3D structure of SFV spherule's complete neck-complex and identifying the host co-factors interacting with viral proteins. To accomplish the main goal of the CryoARC project, I will address the following objectives (1) Fractionation and purification of active SFV spherules from the infected mammalian cells for proteomics and structural studies, (2): In situ cryo-ET structure determination of the SFV spherule’s complete neck complex, and (3) Macromolecular interaction between viral and host-factors in the RC, and design potential antiviral drugs using computational approaches. The result of the CryoARC project will provide a novel fundamental insight into alphavirus replication, thus aiding development of future therapies for emerging medically and economically important Alphaviruses. The CryoARC project is further designed to allow me to utilize and share my own expertise in virology and protein structural biology, and to benefit from the inspiring and well-equipped host research laboratory. Acquired scientific and management skills will help me on the path towards establishing an independent research lab in Europe.

Keywords: alphavirus,rna viruses,3d protein structures,rna replication,electron microscopy,cryo electron tomography,mass spectroscopy,proteomics,antivirals,inhibitors,viral host interactions,cryo em
Targeting R2TP/TTT/WAC/mTOR complex in ovarian cancer. (WAC-mTOR-OC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Ovarian Cancer (OC) is the most lethal gynecological tumor and has an especially high impact in Europe. 70% of patients develop an advanced stage due to the lack of early diagnosis tools and chemotherapy resistance. Therefore, a better understanding of altered molecular mechanisms driving OC progression is needed. Preliminary data from the host lab suggest that a complex formed by R2TP/TTT/WAC upon glucose and glutamine depletion, impairs mTOR activation. Moreover, the components of this complex are co-expressed in OC, a disease influenced by mTOR signaling and metabolic reprogramming. Thus, our hypothesis is that WAC regulates an mTOR activation pathway that influences OC progression and response to chemotherapy and that targeting this complex is a potential therapeutic prospect for the treatment of OC. In particular, we propose to (i) establish the mechanism and role of the R2TP/TTT/WAC/mTOR complex in OC and (ii) to identify new therapeutic strategies targeting this complex for the treatment of OC. We have envisioned this project as a diverse node of cancer signaling and protein experts, with a predicted outcome highly transferable to society. The translational character of this proposal, from molecular mechanism to therapeutics, relies on the integration of an interdisciplinary team formed by the host group proficiency in Structural Biology and my expertise in Molecular Biology and Drug Discovery, together with scientific experts on Experimental Therapeutics and Bioinformatics from the host institution and collaborators. Importantly, I will have the opportunity to develop new professional skills by both scientific exchanges and specific courses and to participate in dissemination activities to translate our findings to the scientific community and society. Thus, the MSCA fellowship will allow me to develop unique technical and transferable skills, to help me progress in my career developmental plan and establish myself as a leader in cancer research in Europe.

Keywords: ovarian cancer,mtor,wac
Multimodal meanings for conceptual communication before and beyond spoken language (MultiMeans)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

Language is our most potent cognitive and cultural tool, through which we can shape one another’s minds, share information and build knowledge collectively across generations. This is crucial during development: infants build knowledge to the extent that adults offer the appropriate scaffold, i.e. if the teaching material is tuned to the infant’s current understanding. At present, it is hotly debated whether we can open communication and share knowledge with infants only by means of spoken words, or whether gestures offer equal scaffolding. The growing "baby sign" movement may offer this possibility. Baby sign is a system of symbolic gestures, i.e. signs that have meaning and symbolize concepts. As a result, symbolic gestures are a potential means for exchanging meanings in the preverbal infant/adult dyad. However, this exciting scenario cannot be proved by the existing research, which shows contrasting views that only rely on the indirect interpretation of infant behaviour. Using EEG, the present project will be the first to directly decode the baby brain and establish a direct quantitative comparison with the adult brain to verify whether the two share a common multimodal conceptual space, essential for exchanging meanings before and beyond spoken language. At the scientific level, the project will provide an unprecedented understanding of the origins of human language and symbolic cognition, which are essential hallmarks of our species. By testing whether these core abilities develop not only via the verbal channel (spoken words) but also via the visual channel (symbolic gestures), it may support a paradigm shift in favor of human language as inherently multimodal. At the societal level, the project will test key assumptions of baby signing, whose widespread interest is not equally paralleled by compelling scientific evidence; thus, it will directly impact intervention models that aim to support human language and symbolic cognition during (a)typical development.

Keywords: multisensory processing,language,communication,gestures,semantics,preverbal infants,eeg
Partnership for the Assessment of Risks from Chemicals (PARC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: COFUND actions
Partnership: Chemicals Risk Assessment (co-funded)
Countries involved: France,Denmark,Estonia,Finland,Germany,Hungary,Iceland,Israel,Italy,Latvia,Lithuania,Luxembourg,Netherlands,Norway,Poland,Portugal,Austria,Slovakia,Slovenia,Spain,Sweden,Greece,Switzerland,Belgium,United Kingdom,Croatia,Cyprus,Czechia,Ireland,Montenegro
Call: European partnership for the assessment of risks from chemicals (PARC) (HORIZON-HLTH-2021-ENVHLTH-03, 2021)
Start date: 2022-05-01
End date: 2029-04-30
Duration (months): 84.0
Total project cost (EUR): 400000000.0
EU funding (EUR): 200000000.0
Participants: 209
Project status: SIGNED

PARC is an EU-wide research and innovation partnership programme to support EU and national chemical risk assessment and risk management bodies with new data, knowledge, methods, networks and skills to address current, emerging and novel chemical safety challenges. PARC will facilitate the transition to next generation risk assessment to better protect human health and the environment, in line with the Green Deal?s zero-pollution ambition for a toxic free environment and will be an enabler for the future EU ?Chemicals Strategy for Sustainability?. It builds in part on the work undertaken and experience acquired in past and on-going research and innovation actions, but goes beyond by its vocation to establish an EU-wide risk assessment hub of excellence. To contribute to several expected impacts of destination 2 ?Living and working in a health-promoting environment?, PARC will organise the activities to reach three specific objectives: - An EU-wide sustainable cross-disciplinary network to identify and agree on research and innovation needs and to support research uptake into regulatory chemical risk assessment. - Joint EU research and innovation activities responding to identified priorities in support of current regulatory risk assessment processes for chemical substances and to emerging challenges. - Strengthening existing capacities and building new transdisciplinary platforms to support chemical risk assessment. The Partnership brings together Ministries and national public health and risk assessment agencies, as well as research organisations and academia from almost all of EU Member States. Representatives of Directorates-General of the EC and EU agencies involved in the monitoring of chemicals and the assessment of risks are also participating. PARC will meet the needs of risk assessment agencies to better anticipate emerging risks and respond to the challenges and priorities of the new European policies.

Keywords: chemicals,mixtures,exposure assessment,environmental and human monitoring,hazard assessment,eco toxicology,adverse outcome pathways,integrative approaches for testing and assessment,fair data
Co-operation for the Convention on Biological Diversity (CO-OP4CBD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Coordination and support actions
Countries involved: Belgium,France,Finland,Norway,Bulgaria,Hungary,United Kingdom
Call: Cooperation with the Convention on Biological Diversity (HORIZON-CL6-2022-BIODIV-01, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 4389748.75
EU funding (EUR): 4359748.75
Participants: 9
Project status: SIGNED

CO-OP4CBD aims to enhance coordination of the EU support to advance the implementation of the CBD, and doing so make more effective use of existing expertise and initiatives. This will lead to greater coherence in the ways in which the EU, its Member States and associated countries identify and draw on available expertise, improved advice and support to a range of CBD processes, and a more coordinated and cooperative approach in the engagement of experts in supporting implementation of other intergovernmental agreements and processes. Therefore the core focus of CO-OP4CBD is to support the increase facilitation of technical and scientific cooperation in European countries and elsewhere. This will be achieved through the implementation of a set of Coordination and Support Actions: 1) building on existing networks of experts and institutions; 2) engaging experts into the CBD processes; 3) supporting the implementation of monitoring, reporting and review; and 4) increasing technical and scientific cooperation. These actions are targeted at and will benefit the EU, its Member States and associated countries. Many actions and outputs of CO-OP4CBD however will be of interest and use to other Parties to the CBD.

Keywords: cbd,technical and scientific cooperation,clearing house mechanisms,synergies,capacity building,implementation,monitoring,review,post 2020 global biodiversity framework
The Dynamics of Attribute Weighting in Multiattribute Choice (DYNATT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Ireland
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 2109549.0
EU funding (EUR): 2109549.0
Participants: 2
Project status: SIGNED

How much flavour do we give up in pursuit of a healthier choice, and how many extra minutes of commute do we sacrifice in fostering a more sustainable future? Daily decisions involve navigating multiattribute tradeoffs by assigning weights to different attributes. Understanding the mechanisms underlying attribute weighting is key to explaining and predicting choice behaviour. However, these mechanisms are poorly understood. Past research has examined how people adjust attribute weights in response to shifts in goals or in the context. Beyond induced shifts, it is unknown whether attribute weights maintain stability in stationary contexts, from one decision to the next. My central hypothesis is that, akin to other representations in the brain (e.g., memories), attribute weights are in constant flux, being controlled by inherently noisy and dynamical processes. This project aims to unravel these processes. Attribute weights are inherently subjective and not directly observable. Reading them out from single choices is impossible, as choices are perturbed by noise and influenced by normatively irrelevant factors. To overcome this limitation, I will use multiattribute choice tasks with magnetoencephalography and, focusing on decision-relevant neural signals, I will separate the influence of attribute weights from the distorting influence of irrelevant factors. This will enable me to read-out attribute weights at each decision, and to subsequently chart their temporal dynamics across successive multiattribute decisions. Understanding the dynamics of attribute weighting will offer mechanistic insights on how preferences change, informing century-old debates on the nature of preferences. These insights will be valuable to clinicians seeking to understand pathological preference variability or persistence (e.g., in addiction); and to policy makers probing whether specific consumer tradeoffs (e.g., between monetary and environmental attributes) are stable or changeable.

Keywords: decision making attention multiattribute choice choice dynamics preferential choice magnetoencephalography cognitive neuroscience
Modelling nanoparticle transport in the extracellular matrix: improving drug delivery with ultrasounds (ModEMUS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Norway,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-08-01
End date: 2025-08-31
Duration (months): 25.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 2
Project status: SIGNED

Cancer is the second most important cause of death in Europe, with an estimated 2.27 million new cases and 1.3 million deaths in 2020. The prerequisite for a successful medicinal therapy is that the drug reaches its target and that toxicity towards healthy tissue is limited, however the systemic injection of drugs leads to less than 1 % of the drugs accumulating in solid tumours. Relying on the permeability of the blood vessel in cancer tumours, the encapsulation of drugs in nanoparticles (NPs) constitutes a promising approach for cancer treatment. However, the homogeneous distribution of NPs in the tumour tissue remains a challenge. To reach all cells in the tumour the NPs must cross the extracellular matrix (ECM), a major component of solid tumours consisting mainly of a network of collagen fibres embedded in a hydrophilic gel of proteoglycans. Together, they limit the diffusion of drugs across the tumour. Focused UltraSound (FUS) exposure has been reported to improve the delivery of NPs to tumour cells. FUS induces acoustic radiation force and cavitation that can lead to microstreaming or shock waves but the underlying mechanism(s) for the improved transport are not well understood. Successful delivery depends on many factors including the pathology, structure and composition of the diseased tissue, the characteristics of the NPs, and the exposure parameters of the FUS, making it a complex problem difficult to solve using an experimental approach. In this project, we will use molecular modelling to identify correlations between the molecular details of NPs and ECM, and FUS exposure parameters with NP transport across the ECM, creating a predictive model for FUS delivery of NPs and drugs to diseased tissue. The model, validated by experimental data, will contribute to the design of personalized medicine for improved NP-based drug delivery.

Keywords: molecular modelling nanoparticle transport drug delivery ultrasound irradiation langevin dynamics
Project Metalis (Project Metalis)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Slovenia
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-09-30
Duration (months): 15.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

AIONIS d.o.o. is a deep-tech start-up company developing the next generation of metal additive manufacturing machines. With it's patented technology, AIONIS d.o.o. aims to revolutionise metal 3D printing, by speeding up the process of producing metal 3D printed parts. Project Metalis aims to analize the metal additive manufacturing market, update the scale-up business model of AIONIS d.o.o., and secure an investment to implement said business model. Metal additive manufacturing market includes sales of metal 3D printers as well as metal 3D printed parts, which are already in use in the automotive, aerospace, medical devices, metal tooling industry, and other related industries. The most viable business solution to fullfill the market demand for metal 3D printed parts shall be chosen based on freshly gathered market analysis data, the business model will be updated to fit the current market demands, and an investment shall be secured to implement the scale-up of AIONIS d.o.o.

Keywords: market analysis,updated business plan,securing investment
Quantum Adaptive Real-time Error Correction (QuARTEC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 401232.0
EU funding (EUR): 401232.0
Participants: 2
Project status: SIGNED

A major focus of current quantum technology research is noise mitigation, whether through material improvements, decoupling strategies, or the design of noise-resistant quantum devices. Traditional non-adaptive methods struggle with unpredictable errors, such as solid-state defects, quantum information leakage, and correlated noise across qubits, limiting their efficiency. In the Quantum Adaptive Real-time Error Correction (QuARTEC) project, I will implement a novel approach that continuously monitors noise fluctuations and dynamically adjusts qubit control signals, optimizing quantum error correction (QEC) in real time. This builds upon my experience in real-time quantum feedback with single quantum bits (qubits). By employing adaptive real-time techniques, QuARTEC addresses the limitations of conventional methods, significantly enhancing the stability and scalability of quantum processors while relaxing demanding error correction thresholds. I will receive high-fidelity multi-qubit operation training from experts at MIT and the University of Regensburg. The training provided through QuARTEC, with support from the MSCA-PF, will equip me to pursue a leadership role in the quantum field, whether in academia or industry. The project will shift the burden of noise resilience from fragile quantum hardware to robust classical control systems. QuARTEC will leverage the synergy between quantum control, computation, and computer science to drive the next generation of quantum computing technologies.

Keywords: quantum computing,quantum feedback,quantum control,superconducting qubits,spin qubits