Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Novel Loop-Heat-Pipe (LHP)-based Data Centre Heat Removal and Recovery System Employing the Micro-channels Cold/Hot Plates (LHP-C-H-PLATE-4-DC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-09
End date: 2021-09-08
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Date centres consume 1.1-1.5% of the world’s total electricity supply and remain 15-20% of annual increase rate in power demand. Space cooling, owing to vast dissipation of the heat from the data-processing equipment to data centre space, has a very high cooling capacity, accounting for 30-40% of energy delivered into the space. Developing an effective heat removal and recovery system to prevent excessive equipment heat transmission to the space is critical to reducing energy consumption of the cooling system. The proposed MSCA programme aims to investigate an innovative a novel Loop-Heat-Pipe-based data centre heat removal and recovery system employing the micro-channels-cold/hot-plates(LHP-C/H-PLATE-4-DC), by integrating the excellence of the host applicants in loop-heat-pipe(LHP) and expertise of the researcher applicant in hot/cold plates for data processing equipment. The innovative features of the system lie in (1) microscopic interior spaces increase liquid evaporation rate and heat transfer of the LHPs; (2) sensor-controlled liquid upper-feeding and liquid/vapour separator prevent the dry-out and entrainment effects of the conventional LHPs; (3) flat-plate surface of the cold-plate enables a perfect contact with the skin of the data-processing equipment; and (4) novel heat/mass transfer analysis approaches employing the latest fractal and enthalpy/temperature-difference-driven heat transfer theories. The programme tasks include (a) concept development; (b) computer modelling; (c) prototype construction & testing; and (d) economic & environmental analyses. The programme will attract an experienced researcher with particular knowledge in data centre heat removal technologies into Europe. This will (a) achieve transfer of knowledge from outside into Europe, thus helping growing EU’s knowledge-based economy and society; (b) develop a long-term contact among the researcher and host/partner organisations; and (c) enable the advanced training to the researcher.

Keywords: micro channel,loop heat pipe,heat removal,heat recovery,data centre,cooling,energy,consumption,cooling load,heat transport capacity,computerised tool,experiment
Material properties in the strong light-matter coupling regime (MaP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

An electromagnetic mode without photonic excitations still has a non-zero energy - called zero-point energy. The resulting vacuum fluctuations give rise to long known physical effects such as the spontaneous emission. By engineering electromagnetic modes in cavities, vacuum can be made to interact with matter in the extensively studied weak, strong and ultrastrong light-matter coupling regimes. The term `light-matter coupling', as well as the optical experimental means by which the regime is usually studied, hides this important fact: vacuum alone gives rise to the coupling and to the mixed light-matter excitations (polaritons) of the system. In physics, still only few experimental platforms have allowed to observe `vacuum-matter coupling' without photonic excitations. Properties of materials dressed by a cavity were successfully observed by measuring their conductivity [Orgiu et al. Nat. Mater. 14, 1123 (2015); Paravicini-B. et al. Nat. Phys. 15, 186 (2019)]. In recent years, the new field of polaritonic chemistry has identified other material properties altered by vacuum coupling, including chemical reaction rates and thermodynamic properties. In this project, we intend to expand the new experimental access to the matter part via conductivity measurements to an entirely new system. So far, only highly disordered organic semiconductors [Orgiu] and very high mobility GaAs based electron gases were used [Paravicini-B.]. Here, we suggest a new platform using transition metal dichalcogenides inside a plasmonic cavity. This should work at room temperature and shed more light on the mechanism responsible for vacuum field assisted charge transport. In a second project, we attempt to alter phase transition properties by dressing a chemical to a cavity. Both projects aim to explore the potential of engineering properties of materials with a cavities vacuum field mode. They both mostly rely on optical, electronic and chemical experimental tools available in the host group.

Keywords: strong light matter coupling,vacuum field fluctuations,cavity quantum electrodynamics
Delivering Advanced Predictive Tools form Medium to Seasonal Range for Water Dependent Industries Exploiting the Cross-Cutting Potential of EO and Hydro-Ecological Modeling (PrimeWater)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European research in support of international space partnerships
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Australia,Germany,Sweden,Greece,France,United States,United Kingdom
Call: International Cooperation Copernicus – Designing EO downstream applications with international partners (H2020-SPACE-2019, 2019)
Start date: 2019-12-01
End date: 2023-05-31
Duration (months): 42.0
Total project cost (EUR): 2077679.99
EU funding (EUR): 2013827.99
Participants: 10
Project status: SIGNED

PrimeWater aims to maximize the potential of the Earth Observation (EO) technologies for the water sector by enhancing and expanding the information base for inland water quality attributes, through advanced physics-based algorithms that integrate multi- and hyper-spectral imagery from satellite, airborne and ground-based sensors, increasing the situational intelligence of water regulators, emergency planners, water-related industry professionals and local communities. PrimeWater aspires to further add value to EO data and other Copernicus sectoral services through cross-cutting research with Data Assimilation (DA) and Machine Learning (ML) techniques aiming at improving the skill of hydro-ecological forecasts and their related impact at different spatial scales and time horizons, and hence improve preparedness against water hazards and enhance the capacity of decision-making through uncertainty information. PrimeWater will establish a complete value chain linking science with the water business sector, ensuring the co-development of products and services through continuous and efficient interaction and communication with water professionals across the globe and in-depth analysis of the intrinsic barriers for the wide market uptake of EO-enabled services in the water sector. As a result PrimeWater will deliver water intelligent services that capitalize on advanced EO data products and intersections with other data sources, will build on cause-effect analyses through diagnostic modelling tools, and will utilize predictive and prescriptive calculations by integrating forecasting capabilities with planning and scenario analysis.
Non-equilibrium features of small systems within critical liquids. (NEQLIQ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: SIGNED

NEQLIQ aims to contribute to the European Research Area (ERA) by developing new fundamental knowledge about the features of small systems. Particularly, NEQLIQ will focus on the dynamics and energetics of small systems within critical baths. Critical interactions have been proposed to play a key role in the performance of living systems, and they have great perspectives to be applied to artificial devices. NEQLIQ is based in: i) micelle-solvent mixtures to enhance the intrinsic critical features of a binary-fluid, ii) a combination of microrheology and dynamic light scattering for determining the impact of confinement or inclusion of tracers in the viscoelastic features of the fluid, and iii) the study of the statistics of the energy transfer by non-equilibrium thermodynamic protocols. The objectives of NEQLIQ have a direct impact on some of the ‘Societal Challenges’ listed in H2020 i.e. ‘Secure, Clean and Efficient Energy’ and ‘Climate Action, Environment, Resource Efficiency, and Raw Materials’. NEQLIQ will merge the expertise of the host group in surfactants, micelles, and microfluidics, together with the background of the applicant using optical micromanipulation technique to unravel the fundamental features of the energetics of small systems, to reach the scientific objectives and technological challenges, to reach the desired deliverables and milestones. An ambitious training program including several new scientific and soft skills to be transferred to the applicant is also envisaged. Moreover, the applicant will transfer his knowledge to the host group and will be the link between them to forge future collaborations. Altogether, NEQLIQ will give the candidate a challenge to gain new expertise in different areas of research and new soft skills and leadership capacities. Hence, MSCA will position him at the forefront of the young researchers in the ERA, paving his way to reach a position as a principal investigator at a University in the European Union.

Keywords: critical systems,optical tweezers,micellar dynamics
Intelligent Automatic Sign Language Translation (EASIER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Switzerland,Switzerland,Belgium,Greece,France,France,Netherlands,United Kingdom,United Kingdom
Call: An empowering, inclusive Next Generation Internet (H2020-ICT-2020-2, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 3991591.25
EU funding (EUR): 3991591.25
Participants: 14
Project status: SIGNED

EASIER aims to create a framework for barrier-free communication among deaf and hearing citizens across the European Union by enabling users of European Sign Languages to use their preferred language to interact with hearing individuals, via incorporation of state-of-the-art new machine translation technology that is capable of dealing with a wide range of languages and communication scenarios. To this end, it exploits a robust data-driven sign language (video) recognition engine and utilizes a signing avatar engine that not only produces signing that is easy to comprehend by the deaf community but also integrates information on affective expressions and coherent prosody. The envisaged ecosystem will incorporate a robust translation service surrounded by numerous tools and services which will support equal participation of deaf individuals to the whole range of everyday-life activities within an inclusive community, and also accelerate the incorporation of less-resourced sign languages into sign language technologies, while it leverages the sign language content creation industry. The deaf community is heavily involved in all project processes, while deaf researchers are among the staff members of all sign language expert partners.

Keywords: neural machine translation,deep learning,sign language translation
Dopaminergic neurons and the reward system in fish: a functional neuroanatomical multidisciplinary study (FISHDOPA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

The current proposal aims at elucidating the role of the dopaminergic (DA) system in regulation and control of reward systems. The study of DA regulation is of great importance since it has been known to regulate reward, as well as other vital neurological functions and several neuropsychological illnesses, but the underlying molecular mechanisms are still not fully understood. With the emerging technologies of in vivo imaging, optogenetics and transgenic techniques, it is today possible to better study the molecular mechanisms underlying reward behaviour. To this end, the zebrafish (Danio rerio) is an excellent model system where these tools are amenable for complex network analyses. It is believed that, as in mammals, DA neurons provide a central role in signal and response to salient stimuli. Therefore in this project we plan to 1. Establish which forebrain DA neuronal populations, brain targets and signalling molecules are active during reward conditions and 2. Establish a causal relationship between these areas and the control of reward-motivated behaviour in fish. We will conduct this research by pinpointing DA neuron populations active during reward situations and their target areas by in vivo calcium imaging analysis and corroborating established focus brain networks by quantifying c-Fos and brain-derived neurotrophic factor (BDNF) expression by means of in situ hybridization (WP1). Thereafter, we will elucidate target molecules that are important during reward processing in established networks, by laser microdissection and a targeted and non-targeted approach, i.e. qPCR and RNA sequencing, respectively (WP2). Finally we will demonstrate causality between focus brain networks and reward oriented behaviour by optical and genetical regulation, i.e. optogenetics, of neural population activity (WP3). Extrapolating information obtained from these results could help predict neurobiological principles that could be the basis for therapeutic interventions.

Keywords: dopamine,reward,zebrafish,neural networks,optogenetics,calcium imaging
Investigating the mechanism of spatiotemporal control over genome activation by Zelda in an in vitro reconstituted system (ZELDA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

A long-standing question in biology is how do transcription activators and repressors exert their function over large batteries of specific targets spread throughout the genome in a timely and coordinated way. An excellent model system to study this process is zygotic genome activation (ZGA) that happens during development of every animal and hallmarks initiation of transcription from the zygotic genome. During ZGA, developmental cues such as morphogen gradients are converted into coordinated and robust spatiotemporal patterns of gene expression. I will study the mechanisms that govern this process by focusing on transcriptional activator Zelda – a key protein that orchestrates ZGA in Drosophila melanogaster. Using in vitro assays on purified recombinant proteins, I will investigate Zelda’s interactions with DNA, chromatin, RNA and transcription factors and examine the capability of such reconstituted system to recapitulate key aspects of gene regulation such as local clustering of regulatory DNA regions and transcription factors. I will examine structural and biophysical properties of Zelda, test its propensity to undergo liquid-liquid phase separation and explore the consequences it has for its interactions with its binding partners and its function. The in vitro approach will be combined with in vivo experiments in Drosophila using tagged wild-type and mutant variants. This combined approach will give us novel insights into mechanisms governing zygotic genome activation as well as general rules of transcriptional regulation. Local clustering of enhancer and promoters emerges as a general principle of transcriptional regulation. Understanding the mechanisms that could drive formation of these micro-domains is therefore of paramount importance, not only to basic biology, but also for development of new strategies to treat diseases caused by transcriptional dysregulation.

Keywords: organisation of transcription,zygotic genome activation,in vitro reconstitution,liquid liquid phase separation
Regulatory Science Framework for Nano(bio)material-based Medical Products and Devices (REFINE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Ensuring the safe and sustainable development and application of nanotechnologies
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Ireland,Italy,Switzerland,Norway,Belgium,France,France,Netherlands,United Kingdom,United Kingdom
Call: Regulatory Science Framework for assessment of risk benefit ratio of Nanomedicines and Biomaterials (H2020-NMBP-2017-two-stage, 2017)
Start date: 2017-12-01
End date: 2022-02-28
Duration (months): 51.0
Total project cost (EUR): 7967941.0
EU funding (EUR): 7967941.0
Participants: 18
Project status: CLOSED

REFINE proposes a Regulatory Science Framework for the risk-benefit assessment of medical products and medical devices that are based on nanomedicines and biomaterials. The heart of our framework is the development of a product-specific Decision Support System that identifies the most efficient way to deliver the data required by regulation by the best-fitting methods. The decision tree will explicate the product’s specific regulatory challenges and the priorities of both missing data and missing methods to match these challenges. It will thus allow planning a cost-and time efficient strategy both for necessary measurements and for the advancement of methods. Our approach is aligned with the industrial R&D practice of stage gating. We will demonstrate the relevance of the framework for the most pressing regulatory challenges, which are: borderline products, nanosimilars, and products combining several functionalities. In order to do so, we will identify the regulatory challenges with Regulation Authorities from Europe and abroad, and design methods for tiered decision tree, guided by the latest scientific knowledge. We will study/predict physiological distribution of nanomedicines and biomaterials, as well as develop and validate new analytical or experimental methods and assays requested by the regulators. These latter development will be performed in a quality management system, ensuring the possible standardisation of our assays. REFINE will gather a wide community of stakeholders in regulation, industry, science, technology development, patients, and end-users, into a Consortium for the Advancement of Regulatory Science in Biomaterials and Nanomedicine.

Keywords: regulation,nanomedicine,biomaterials,medical devices,assays,dss or decision making,regulatory framework,medicinal innovation,risk assessment,knowledge base,international cooperation
New strategies for the formation of two-dimensional covalent organic frameworks (2D-COFs) on surfaces. (CustomCOF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

Organic chemistry, including polymer synthesis, has a great impact on society, since many consumer goods would not exist without these chemistries. Most often, organic synthesis is carried out in solution and, despite the fact that it is a proven powerful approach, new synthetic strategies are needed for the formation of the next generation of complex materials. One kind of functional materials that receive great attention nowadays are the so-called two-dimensional covalent organic frameworks (2D-COFs). Basically, these are extremely thin films (one-molecule thick) that are often crystalline in two dimensions, and that contain nanopores. Potential applications of this type of materials range from superthin membranes to advanced electronics. This innovative project deals with the use of surfaces to template the formation of such sophisticated 2D-COFs. New synthetic approaches are explored, not only to generate the next generation of this type of materials with unique topologies and functionality, but also to conceive smaller versions of these 2D-COFs with a well-defined size. In this highly interdisciplinary project, we use atomically flat substrates that act as support for the formation of these new networks. These exciting novel 2D-COFs are not only of interest by themselves, but they also nanostructure and functionalize the surfaces they are adsorbed on. CustomCOF will provide an exceptional platform to acquire new knowledge through research and training, to reach scientific maturity, leadership and independent thinking, strengthening my team-working spirit, individual personal development training and my willingness to assume responsibilities and accept risks, which are always important assets to obtain high-quality results. It will offer networking opportunities and international collaborations. In brief, this MSCA grant will be a turning point in my career towards scientific excellence.

Keywords: covalent organic frameworks,scanning probe microscopies,dynamic covalent chemistry,host guest systems,organic chemistry