Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
KEEN Quality Keeper - A Competence and Quality Assurance System representing a totally new standard for the health care sector (KEEN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Norway
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Across the EU we are aiming for more safe and secure care facilities, but with fewer resources than before. At the same time, the public scrutiny and the tolerance for error among key incident stakeholders is decreasing. Current approaches cost valuable time, requiring complex planning exercises with inherent risk of unnecessary errors. Especially when facing current restraints of available staff, minimizing read tape with a limited budget in mind. A novel approach is required to reduce risks of incidents in a cost-effective way, improve care staff training and ensuring full documentation in e.g. insurance cases to ensure full reparations, through full, cost-effective compliance. This is reinforced by increasing restraint on the nurses’ time, and urges additional training, to ensure a high quality of care; at the same time remaining fully compliant with safety and security regulation, e.g. being perfectly prepared for first aid, fire and fall incidents 24/7, ensuring recent training for all teams. KEEN Quality Keeper (KEEN) a disruptive Competence and Quality Assurance System reduces the risks of costly accidents and comply with legislation by continuously training nursing homes staff to ensure proper certification. With the SME instrument support we will validate KEEN internationally with nursing homes, but also service flats, home care services and hospitals, scale-up our cloud platform and implement the functional improvements, preparing KEEN for full speed market launch by 2019. Now is the perfect time for KEEN to enter the market. Combining our fast market expansion strategy with the need growth will allow us to reach 50M EUR 5 years after completing the project (2024). KEEN has been developed to the stage where it is ready for testing under real world conditions. A Feasibility Study will verify the technical, regulatory, commercial and economic viability of its implantation, which will lead us to the formulation of an elaborated business plan.

Keywords: health care,competence,quality assurance system,nursing homes,staff training
New biology of oncogenic PI 3-kinase (Oncogenic PI3-kinase)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

PI 3-kinase (PI3K) signalling regulates multiple cell functions and is one of the most frequently genetically-activated pathways in cancer. This is mainly due to activating mutations in PIK3CA (the gene encoding the PI3Kα catalytic subunit) or inactivation of the tumour-suppressor PTEN (which opposes PI3K signalling). Solid tumours are most often hypoxic and nutrient-starved. The central premise of my proposal is that PI3K signalling has thus far been predominantly investigated under experimental settings not representative of these cancer-relevant tissue contexts. In our view, this has resulted in an incomplete understanding of PI3K biology in cancer. Based on this assertion, I have formulated two key objectives: (1) To uncover previously-unappreciated signalling mechanisms of oncogenic PIK3CA under cancer-relevant conditions of long-term starvation and/or hypoxia. (2) To understand the mechanism of cell death induced by an innovative, new type of PI3K modulators, generated by the Host Lab, that kill PIK3CA-mutant cancer cells under hypoxic conditions. These objectives will be achieved by, respectively: (1) Biased and unbiased genetic and pharmacological approaches in cells and mice, including probing signalling under conditions of (A) nutrient and/or oxygen starvation (B) sustained low-level signalling due to genetic PIK3CA activation in the heterozygous state and from the endogenous promotor, as is the case in cancer. (2) Using unique small-molecule PI3K pathway modulators developed in the Host Lab, in cell-biological and signalling studies. These objectives will merge my expertise in signalling under nutrient-starved conditions with world-class know-how in PI3K cancer studies and drug development in the Host Lab. This proposal aims to make scientific breakthroughs in understanding cancer-related PI3K signalling, promoting the progression of my career and allowing the Host Lab to achieve its key long-term aim to make PI3K-based cancer therapies work.

Keywords: signalling,pi 3 kinase,cancer,hedgehog,embryonic development,mouse model,cell biology
The Judy Project: A Critical and Historical Investigation of Women and Puppetry from the Eighteenth to the Twenty-First Century (JPEWP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 337400.64
EU funding (EUR): 337400.64
Participants: 1
Project status: SIGNED

The Judy Project: A Critical and Historical Investigation of Women and Puppetry from the Eighteenth to the Twenty-First Century (JPEWP) is the first transhistorical examination of the (re)presentation of gender and identity in Punch and Judy one of the most iconic English puppet traditions. Despite a growing interest in puppet theatre, scholarship does not typically delve into gender issues. The inclusion of women as practitioners and theoreticians, and critical analyses of female figures are scarce. My research, however, shows that women have been inserting themselves throughout its history in significant and under-examined ways. JPEWP will focus on women practitioners as invisible or concealed labour and innovators, and ways the female puppet figure reveals and conceals dominate ideology and anxiety about the female. This project investigates inscriptions and subversions of gender, tracing both its history and alternative, and feminist interpretations focusing on the female character Joan/Judy beginning with early Modern representations of the female figure to contemporary radical feminist re-imaginings. To manage the expansive time frame, I will use case studies from specific culturally volatile moments situated within a trans-historical framework that will be connected through the theoretical approach and common questions. The project will be an interdisciplinary investigation that goes beyond standard understandings of ‘text’ to offer innovative analyses of what is usually seen as archival ‘ephemera’ in order to detect the traces that remain of puppet theatre. As violence against women and female bodies increases and in light of renewed interest in institutionalized sexism, this research investigates: how the female body is presented in a popular performance form, by whom and why. Further, by questioning the narrative of a traditional form and its history, this work destabilizes orthodox notions of a singular male dominated history.

Keywords: puppet theatre,women and performance,popular entertainment
RAPID DISCOVERY AND DEVELOPMENT OF ENZYMES FOR NOVEL AND GREENER CONSUMER PRODUCTS (RADICALZ)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Spain,Switzerland,Croatia,France,France,Netherlands,United Kingdom,Denmark,United Kingdom
Call: Enzymes for more environment-friendly consumer products (H2020-FNR-2020-2, 2020)
Start date: 2021-06-01
End date: 2025-05-31
Duration (months): 48.0
Total project cost (EUR): 6004308.91
EU funding (EUR): 6004308.75
Participants: 14
Project status: SIGNED

The application of enzymes in industrial processes is increasingly important to achieve the EU’s sustainability goals and strengthen the bioeconomy, replacing oil-based chemistry. However, enzymes still find hurdles for their industrial application: low success rates of discovery and engineering; tedious and expensive methods to explore diversity; and limited activity/stability in the final application. RADICALZ assembles an interdisciplinary and intersectoral consortium to deliver faster, more versatile and more affordable tools for enzyme discovery and engineering, enabling the development of novel enzymes, new formulations and ingredients for more environment-friendly and healthier consumer products. This project will: i) develop new droplet microfluidic tools to find suitable enzymes for consumer products; ii) develop user-friendly software solutions based on machine learning (ML) for faster and more accurate enzyme engineering; iii) develop novel enzymes and bio-based, bio-catalytically synthesized ingredients for consumer products (glycosides, wash-enhancing enzymes, bio-based thickeners, natural antioxidants and fragrances); iv) develop bio-based, condition-responsive capsules for the protection and triggered release of enzymes and ingredients in the formulation of consumer products. RADICALZ will reduce the average time for enzyme discovery and evolution to <4 weeks, access 10 bio-based ingredients to replace oil-based chemistry, reducing the environmental impact –supported in depth in ≥3 cases– across 3 different types of consumer products. RADICALZ assembles 6 leading European companies and 6 pioneer academic teams expert in enzyme discovery and evolution, biocatalysis, chemical engineering, microbiology, soft-matter physics and microfluidics. The planned activities span 48 months and 7 work packages. The project is estimated at ca. 6 M€ (42% allocated to industrial partners and 64% of the total dedicated to creating highly-qualified jobs).

Keywords: microfluidics,metagenomics,protein engineering,machine learning,bioprocess sustainability
Verified Extraction from Coq to OCaml with GADTs (Coqaml)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-12-01
End date: 2023-11-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

The Coq proof assistant is a popular tool to verify the correctness of security-critical software. The CompCert C compiler, some implementations of blockchain languages, and the implementation of the P-256 elliptic curve in Google’s BoringSSL library are all OCaml programs obtained by extraction from Coq functions. While a type checker for Coq has recently been verified via a machine-checked mathematical proof based on the MetaCoq project for verified meta-programming, the extraction process from Coq to OCaml is still part of the trusted computing base (TCB). The Coqaml project will minimise the TCB for extracted programs even further by also providing a machine-checked correctness proof for the extraction mechanism to OCaml. Under the supervision of Nicolas Tabareau, head of the Inria Gallinette team in Nantes, the experienced researcher (ER) will implement Coq's extraction as mechanically verified MetaCoq-plugin, obtaining the guarantee that extracted OCaml programs behave exactly like the Coq function specified. In order to be usable in industrial applications, Coqaml will include a novel extraction targeting generalized algebraic datatypes (GADTs) in OCaml. The project includes a secondment of the ER to Nomadic Labs in Paris, who require GADTs as target for Coq's extraction. The intermediate semantic correctness proof for type and proof erasure, allowing axioms like functional extensionality or proof irrelevance in verified programs, can also be exploited in other extraction projects like the CertiCoq compiler from Coq to C code. The Coqaml project is interdisciplanary by design, spanning logic, type theory, programming languages, and compilers. The density of some of the world’s leading experts on Coq and type theory in the Gallinette team and the expertise at Nomadic Labs will ensure that the environment is ideal for the success of the Coqaml project and the most beneficial development of the ER, greatly enhancing his future career prospects.

Keywords: ocaml,programming languages,type theory,compilers,meta programming,logics in computer science,program verification,security
Virtual reality aided design blending cross-disciplinary aspects of architecture in a multi-simulation environment (PrismArch)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Italy,Malta,Switzerland,Greece,United Kingdom,United Kingdom,United Kingdom
Call: Interactive Technologies (H2020-ICT-2019-3, 2019)
Start date: 2020-11-01
End date: 2023-01-31
Duration (months): 27.0
Total project cost (EUR): 2325562.5
EU funding (EUR): 1928062.5
Participants: 7
Project status: CLOSED

The recent past of the AEC industry is characterized by digital breakthroughs that have dramatically shaped the design process. The powerful programs that are currently available offer unlimited possibilities, allowing complex and creative designs to be modelled accurately with ease while enabling collaboration and Building Information Modeling. The realization of structurally complex constructions is an inter-disciplinary process that passes through the close collaboration of architects and engineers. By employing advanced VR applications, designers can immersively perceive and interact with the current status of their creations and realize the consequences of their decisions. Unfortunately, these solutions focus on the aesthetic aspect of architecture while ignoring the driving cause hidden behind each architectural creation, functionality, that can only be perceived through advanced simulations combined with powerful visualization. Therefore, architects and engineers that struggle to create complex constructions which abide to high functional standards cannot take full advantage of VR solutions. PrismArch aims to achieve a “prismatic blend” between aesthetics, simulation models and meta-information that can be presented in a contextualized and comprehensive manner in VR in order to allow collaborative manipulation of the design and accurate assessment of new design decisions. This achievement passes through intuitive interactions in a VR world with high-quality photorealistic graphics that satisfies the needs of all types of designers in parallel. By supporting dynamic collaboration among architects, structural and MEP engineers, PrismArch will allow them to jointly decide, preview and assess the outcome of their decisions towards a universal optimal solution. Through PrismArch, the designers will be able to experience in real-time how their decisions affect both their own and other disciplines via a discipline-specific and personalized point of view.

Keywords: virtual reality aided design,architectural design,structural engineering,mep engineering,collaborative design,multi simulation,multi presence,assisted content creation,spatial cognition
Production technology to achieve low Cost and Highly Efficient phOtovoltaic Perovskite Solar cells (CHEOPS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Ireland,Italy,Germany,Germany,Switzerland,Switzerland,Switzerland,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2015-1-two-stage, 2015)
Start date: 2016-02-01
End date: 2019-01-31
Duration (months): 36.0
Total project cost (EUR): 5042913.75
EU funding (EUR): 3299095.0
Participants: 12
Project status: CLOSED

The aim of CHEOPS is to develop very low-cost but highly performing photovoltaic (PV) devices based on the emerging perovskite (PK) technology. At lab scale (<0.5cm2), PK energy conversion was rapidly advanced to efficiencies >20%. But only few attempts at upscaling have been made, yielding significantly reduced efficiencies <9% on aperture area. In addition, the very question about material stability and reliable measurement procedures are still debated. CHEOPS will now scale up the lab results to single junction modules manufactured in a pre-production environment while maintaining high efficiencies (>14% stable for aperture area in modules >15x15cm2). This will demonstrate the potential of PK as a very low-cost technology (target <0.3€/Wp) well suited for building-integrated PV. In parallel, CHEOPS will develop materials and processes to achieve very high efficiency (>29% on 2x2cm2 cells) at low cost (target <0.4€/Wp) using a tandem configuration with a crystalline silicon heterojunction cell. CHEOPS will also perform a sustainability assessment from a life-cycle perspective to anticipate potential risks for the technology (including business, technological, environmental, social & political risks). CHEOPS will establish a quantified future development roadmap as well as protocols for stability testing and for reliable measurements. CHEOPS partners cover the whole value added chain: key PK researchers, groups with track records of scaling up high efficiency and tandem cell developments, specialised technology and service providers as well as SMEs and industry partners with already strong IP portfolios, ready to exploit the CHEOPS results. Transferring the results to other growing industry sectors such as lighting or organic large area electronics will additionally benefit European industry. In summary, CHEOPS will decisively advance the potentially game-changing PK technology towards the market and will thus help to face the energy challenge in Europe and beyond.

Keywords: perovskite,thin film,module,large area,high efficiency tandem solar cell
Illuminating the dark side of surface meteorology: creating a novel framework to explain atmospheric transport and turbulent mixing in the weak-wind boundary layer (DarkMix)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-05-01
End date: 2023-01-31
Duration (months): 69.0
Total project cost (EUR): 1898103.5
EU funding (EUR): 1898103.5
Participants: 1
Project status: SIGNED

Surface meteorology impacts the abundance and quality of life on Earth through the transfer and mixing of light, heat, water, CO2, and other substances controlling the resources for humans, plants, and animals. However, current theories and models fail when airflows and turbulence are weak during calm nights leaving weather and climate forecasts uncertain. This ‘dark side’ occupies substantial fractions of time and our landscape, its physics are largely unknown, and has eluded proper experimental investigation. DarkMix creates technological and theoretical innovations to observe and explain transport and mixing in the weak-wind boundary layer. Its ambitious goal is a radically new framework incorporating unexplored mechanisms such as submeso-scale motions, flow instationarities, and directional shear to effect a quantum leap in understanding the air-plant-soil exchange. DarkMix will build the ground-breaking first-ever fiber-optic distributed temperature sensing harp to fully resolve the 3-dimensional flow and air temperature fields and enable unprecedented computation of eddy covariance fluxes at scales of seconds over 4 orders of magnitude (deci- to hundreds of meters). Both key innovations bear significant risks of technical and fundamental nature, which are mitigated by pursuing alternatives. Measurements will inform cutting-edge large eddy simulations to test hypotheses. The interdisciplinary dimension takes DarkMix to a unique set of weak-wind sites including a valley-bottom grassland, a forest in complex terrain, and a city to investigate topographic effects, the forest carbon cycle, and the urban heat island. DarkMix will open a new window for surface meteorology and its links to air quality, biogeochemistry, and climate change by giving physically meaningful and societally relevant answers to profound questions such as the exchange of greenhouse gases, hazards from ground fog, urban pollution, and agricultural losses through extreme cold air.

Keywords: atmospheric turbulence,distributed temperature sensing,surface layer,dispersion,diffusion,forest and urban climate change