Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Metabolic mechanisms underpinning obesity-driven pancreatic cancer (PancObese)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: United Kingdom
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Pancreatic cancer is one of the most lethal malignancies, showing a high rate of metastatic spread and a dismal prognosis. With almost no effective treatment options, new therapies to treat this devastating disease are urgently needed. Such advances will depend on a better understanding of the mechanisms that drive pancreas cancer progression. Previous work has revealed two interesting features of pancreas cancer on which this proposal is built. Firstly, pancreas cancers contain an extremely high stromal component – normal cells that become part of the tumour mass and contribute to the control of malignant progression. Secondly, obesity – a rapidly growing epidemic worldwide – is associated with increased pancreas cancer development. This proposal aims to understand the mechanisms underlying the link between obesity and pancreas cancer, focusing on the metabolic cross talk between the adipocytes in the tumour environment and the tumour cells themselves. This is a pioneering project that pulls together critical aspects of pancreas cancer biology, building on a solid platform of existing knowledge around the importance of metabolic alterations in cancer and the role of other types of tumour associated stromal cells. State of the art metabolomic analyses and in vivo models will be used to identify novel aspects of metabolic control of the tumour cell environment, how these changes promote pancreas cancer progression and the impact of obesity on these responses. Focusing on the importance of adipocytes, the modulation of reactive oxygen species and the metabolite formate, we will apply our extensive expertise to a new area of study, determining novel mechanisms that underpin pancreas cancer progression. Ultimately, the insights developed by this proposal will provide a rational basis for the development of new therapeutic options. These studies will therefore have far-reaching impact on one of the world’s most devastating diseases.
Rotterdam, Umea and Glasgow: Generating Exemplar Districts In Sustainable Energy Deployment (Ruggedised)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Innovation actions
Countries involved: Italy,Austria,Germany,Italy,Sweden,Poland,Sweden,Sweden,Czechia,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Smart Cities and Communities lighthouse projects (H2020-SCC-2016, 2016)
Start date: 2016-11-01
End date: 2022-10-31
Duration (months): 72.0
Total project cost (EUR): 19342932.41
EU funding (EUR): 17692858.41
Participants: 38
Project status: SIGNED

The RUGGEDISED project will create urban spaces powered by secure, affordable and clean energy, smart electro-mobility, smart tools and services. The overall aims are: 1. Improving the quality of life of the citizens, by offering the citizens a clean, safe, attractive, inclusive and affordable living environment. 2. Reducing the environmental impacts of activities, by achieving a significant reduction of CO2 emissions, a major increase in the investment and usage of RES and an increase in the deployment of electric vehicles. 3. Creating a stimulating environment for sustainable economic development, by generating more sustainable jobs, stimulating community involvement in smart solutions and to boost start-up and existing companies to exploit the opportunities of the green digital economy and Internet of Things. To achieve the aims, a key innovation challenge in all three lighthouse cities of RUGGEDISED is to arrange successful combinations of integrated smart solutions for energy and e-mobility (enabled by ICT platforms and open data protocols) and business models with the right incentives for stakeholders to invest and participate in a smart society. Specific challenges relevant for the lighthouse cities are: - to manage peak load variation in thermal and electrical energy supply and demand; - to develop appropriate cooperation structures and business models for exchange of energy; - to develop Smart City (open) data platforms and energy management systems RUGGEDISED has derived 10 specific objectives and planned 32 smart solutions to meet the challenges. The development of solutions in the lighthouse cities is not the primary goal of the project, but a necessary means to find the right incentives and to create validated business cases to enable large scale deployment and replication of solutions. Three follower cities Brno, Parma and Gdansk have selected 27 smart follower solutions to follow the lighthouse cities and to prepare for implementation in the future

Keywords: internet of things,clean energy,smart electro mobility,smart tools and services,innovative solutions,economic viability,buildings,energy systems,climate change,waste,air quality
Mobile ticketing system for urban transport (BLEticket)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2014-09-01
End date: 2014-11-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

For over years integrated ticketing based on Smartphones has been on the agenda of EU transport policy due to his potential for intermodal transport. The future challenge of transport sector is to combine all urban transport modes (metro, bus, train) on a single ticket facilitating transfer between them and to enable ‘pay per use’ approach offering novel pricing model to passengers. Until now, the only two systems enabling users to pay with Smartphones are based on Quick Response (QR) code and Near Field Communications (NFC) technology. However, none of them can be adopted as mobile eticketing system applicable on a wider scale in Europe; QR code pose serious security risks and NFC suffer with lack of interoperability, limited versatility and is not supported by Apple (iOS), the landmark for mobile technology trends. The overall objective of the project is to provide novel eticketing based on Bluetooth Low Energy (BLE) technology. This new approach represents a real break-through in eticketing systems due to their low cost, low consumption, ultra rapid connection, improved coverage and interoperability of operators and platforms. BLE is already incorporated by Apple and most important brands featuring Android are also adopting it. The proposed system offer huge number of benefits to all stakeholders involved; Bus transport operators will obtain better transport statistics, reduced small-cash transaction, and reduced fare-processing time and better passenger throughput. Passengers will have more flexible mode choice and easier interchange, enhanced ease of use and more flexible choice and easier interchange. Authorities will reduce environment impact, increase in transport usage and reduce traffic congestions. The objective of this phase 1 is to complete a feasibility study to find out the workability and profitability of the business venture. If the result of the feasibility study is positive, we will write the Business Plan and we will apply to phase 2.

Keywords: information and communication technology ict,intelligent transport system its,smart cities,bluetooth low energy ble,eticketing,mobile ticketing
Multimodal and interconnected hubs for freight and passenger transport contributing to a zero emission 21st century (MOVE21)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Countries involved: Germany,Italy,Germany,Germany,Italy,Norway,Belgium,Sweden,Greece,Norway,Netherlands
Call: Cities as climate-resilient, connected multimodal nodes for smart and clean mobility: new approaches towards demonstrating and testing innovative solutions (H2020-MG-2020-TwoStages, 2020)
Start date: 2021-05-01
End date: 2025-04-30
Duration (months): 48.0
Total project cost (EUR): 9479717.5
EU funding (EUR): 8999845.5
Participants: 24
Project status: SIGNED

A swift transition to zero emissions and climate resilient transport systems requires that passenger and freight transport no longer are addressed separately and in isolation from one another. Passenger and freight transport must be addressed together so that policies, infrastructure (physical and digital), vehicles and energy sources serve both. These will be tackled in an integrated and coherent way in six urban nodes: from policy definition, to planning and implementation in the cities cooperating in MOVE21. The tested and integrated approach will then be disseminated across Europe. This integrated approach ensures that potential negative effects from applying zero emission solutions in one domain are not transferred to other domains, but are instead mitigated. It also ensures that European transport systems will become more resilient. Central to the integrated approach of MOVE21 are three Living Labs in Oslo, Gothenburg and Hamburg and three replicator cities: Munich, Bologna and Rome. In these, different types of mobility hubs and associated innovations are tested, and means to overcome barriers for clean and smart mobility are deployed. The Living Labs are based on an open innovation model with quadruple helix partners. The co-creation processes are supported by coherent policy measures and by increasing innovation capacity in city governments and local ecosystems. The proposed solutions will deliver new, close to market ready solutions that have been proven to work in different regulatory and governance settings. The Living Labs are designed to outlast MOVE21 by applying a self-sustaining partnership model that builds on already existing, strong partnerships for zero emission solutions. MOVE21 comprises 24 partners (six public authorities, two public transport companies owned by municipalities, six industry partners (two of which are SMEs), six research organisations and four network organisations) from seven different European countries.

Keywords: urban mobility,multimodality,zero emission mobility,mobility hubs,micro hubs,micro mobility,freight and passenger transport,active modes of transport,integrated transport approach
BeadCAP-DNA: 30-minute on-site DNA test kit (BeadCAP-DNA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Ireland
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-01-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

BeadCAP-DNA aims to create a world-first 30-minute on-site DNA test kit, for food provenance, thereby eliminating the 2 to 5 day wait for DNA results from a central Lab. This is achieved by a novel merging of molecular biology and semiconductor capacitive sensing in a single-use microfluidic disposable DNA test kit. No such solution currently exists. Our prototype has no molecular amplification, i.e. no risk of on-site cross-contamination. It has 3-orders of magnitude response, enabling qualitative and quantitative DNA detection. The first product version is defined with end-user customers as 8-multiplex, aimed at GMO detection & 8-food-species testing to 0.1% limits. 3 patents are pending. BeadCAP kits will address the huge un-met need for fast on-site DNA food diagnostics. Consumer trust will be significantly increased by on-the-spot DNA-ID-tests of food content and GMO’s. BeadCAP will help food processors and retailers eliminate costly quarantines and food recalls, food wastage, risk of reputational damage and loss of sales (e.g. ‘horse-burger’ crisis 2013). BeadCAP will also accelerate uptake of EURL regulations on DNA-testing of food and shell-fish, thus increasing food safety, and reducing food fraud, mislabelling, and adverse health issues. The AltraTech trans-disciplinary team has 30 previous patents and >100 years experience in semiconductors, molecular biology, microfluidics, venture-capital fundraising, and commercialization success. Our ambition is to scale up BeadCAP-DNA to €100M revenue in high-growth niches of the €4B food-test market, and become a full product solutions supplier and world leader in portable on-site point-of-use DNA diagnostics. We've raised €900,000 seed funds to date. In this SME-Inst-Phase-1 feas.study we aim to do DNA trials & investigate technical and commercialization risk reduction. We target Phase-1 final report on 30/11/2014, and aim to submit business-plan to 17/12/2014 SME-Inst-Phase-2 call, target up to €2M.

Keywords: food safety food authenticity food fraud dna testing dna rna snp biosensor magnetic beads microfluidic cmos semiconductor capacitive sensor
INtegrated Spatial PlannIng, land use and soil management Research ActTION (INSPIRATION)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Protection of the environment, sustainable management of natural resources, water , biodiversity and ecosystems
Action type: Coordination and support actions
Countries involved: Austria,Germany,Spain,Italy,Germany,Germany,Switzerland,Slovakia,Belgium,Finland,Poland,Romania,Slovenia,Sweden,France,Czechia,Netherlands,Netherlands,Netherlands,United Kingdom,Portugal
Call: Structuring research on soil, land-use and land management in Europe (H2020-SC5-2014-one-stage, 2014)
Start date: 2015-03-01
End date: 2018-02-28
Duration (months): 36.0
Total project cost (EUR): 2910604.25
EU funding (EUR): 2598760.5
Participants: 28
Project status: CLOSED

The aim of INSPIRATION is to adopt a funder and end-user demand-driven approach to establish and promote the adoption of the knowledge creation, transfer and implementation agenda for land use, land-use changes and soil management in the light of current and future societal challenges. Main objectives are: • Formulate, consult on and revise an end-user oriented strategic research agenda (SRA), • Scope out models of implementing the SRA, • Prepare a network of public and private funding institutions willing to commonly fund the execution of the SRA. INSPIRATION’s mission is to improve the supply and effectiveness of science/knowledge take-up by those who really need it. The proposed methodology is based on a multi-stakeholder, multi-national and interdisciplinary approach that covers the variety of stakeholders (public bodies, business, science, citizens and society) and the variety of relevant. The vehicle to engage with all relevant stakeholders across the Member States is a National Focal Point (NFP) in 16 countries. The NFP’s will organize workshops with national stakeholders of funders, end users and researchers across the various soil and land management disciplines. The results will be taken up, structured along four integrative themes and merging into thematic knowledge needs to satisfy the as yet unmet societal challenges and to ensure that knowledge contributes primarily to enable meeting these challenges. Based on these results a cross country and cross discipline dialogue will subsequently be organized among the relevant user communities, funding bodies and scientific communities in Europe in order to reach a trans-national, prioritized SRA as well as a model for execution of this SRA. Thus to achieve an SRA of which national funders believe that for any Euro they spend, they will get a multitude of Euro’s worth of knowledge in return. Knowledge welcomed to face their national, societal challenges.

Keywords: strategic research agenda,soil sediment system,land take,science policy interface,societal challenges
New enzymatic oxidation/oxyfunctionalization technologies for added value bio-based products (EnzOx2)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Germany,Spain,Germany,Germany,Spain,Spain,Switzerland,Switzerland,Switzerland,Netherlands,Denmark
Call: Innovative efficient biorefinery technologies (H2020-BBI-PPP-2015-2-1, 2015)
Start date: 2016-11-01
End date: 2019-10-31
Duration (months): 36.0
Total project cost (EUR): 5000000.0
EU funding (EUR): 3000000.0
Participants: 13
Project status: CLOSED

Sustainable production of chemical building blocks and other added value products from plant biomass is required for a bio-based economy. However, the biomass biorefineries should benefit not only from the use of renewable feedstocks but also from greener and more efficient bio-chemical technologies. Previous projects have shown the potential of oxidative enzymes in the production of some added value compounds from biomass components. Of special interest are still unexplored oxidation/oxyfunctionalization reactions (of sugar and lipid compounds) by microbial oxidoreductases, including new (self-sufficient) heme-thiolate peroxygenases. In this context, EnzOx2 plans to develop a 100% biochemical conversion of bio-based 5-hydroxymethylfurfural (HMF) into diformylfuran, a platform chemical, and 2,5-furandicarboxylic acid (FDCA), a plastic building-block. Oxidases (flavo and copper/radical) and peroxygenases will be used to perform the three-step oxidation of HMF to FDCA in a co-substrate and side-product free, one-pot conversion. On the other hand, highly (regio/stereo) selective hydroxylation of plant lipids (such as fatty acids, terpenes and steroids) by peroxygenases will be optimized for cost-effective production of flavours and fragrances (F&F), active pharmaceutical ingredients (APIs) and others. ENZOX2 aims to solve some main bottlenecks in these industrial processes by the use of bio-chemical tools (new/engineered enzymes and optimized biotransformations), to be later validated at the pilot/flagship scale. To attain this objective the consortium includes: i) two world leaders in industrial enzymes (Novozymes) and F&F (Firmenich); ii) two chemical SMEs producing HMF and chiral APIs (AVA-Biochem and Chiracon); iii) two specialized biotechnology SMEs (JenaBios and CLEA); iv) one technology centre in the Plastics sector (AIMPLAS); and v) three CSIC institutes and two universities (Dresden and Delft) with expertise in enzyme reactions and bioprocess implementation.

Keywords: bio chemical technologies,bioplastics,biorefineries,biotechnology,building blocks,enzymes,flavours,lipid,oxidases,oxidation,oxyfunctionalization,peroxygenases,process engineering,sugars
3D and 4D Bioprinting: Additive Manufacturing of Smart Biodegradable Hydrogels (4D-Biogel)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2022-05-31
Duration (months): 36.0
Total project cost (EUR): 263732.16
EU funding (EUR): 263732.16
Participants: 2
Project status: CLOSED

The controlled behaviour of biological systems in response to external stimuli is ubiquitous in nature and perceived as a key requirement for the development of advanced functional materials. A good example found in nature is the so-called “sensitive plant” (Mimosa) that responds to touch by rapidly closing its leaves, as a defense mechanisms against herbivores. This quick response to touch is due to rapid water release from specialized cells located at the leaves. In attempt to mimic nature, 4D-BIOGEL project aims to combine new fully biodegradable water-filled hydrogels with additive manufacturing or 3D printing to design smart materials that can undergo a temporal change in their shape under the influence of an external stimulus, giving a 4th dimension to the previously designed 3D object. Light-sensitive structures activated by near-infrared (NIR) are especially appealing, since light can be conveniently pinpointed to the location of interest with the maximum depth of penetration and the minimum damage of tissues. To obtain NIR-sensitive hydrogels, nanoparticles capable of converting light into heat will be incorporated into the hydrogel matrix to afford small volume contraction-expansion changes on demand. This advanced technology offers great potential for the creation of sophisticated dynamic structures with high resolution that could find application not only in regenerative medicine or drug-delivery, but also in robotics or bioelectronics. The 24-month outgoing phase will take place at the University of Washington in Seattle, under the supervision of Dr. Alshakim Nelson - one of the top-class researchers in 3D and 4D printing of hydrogels. The final goal is that during the third year of the fellowship, under the guidance of Dr. Haritz Sardon at the University of the Basque Country in Spain (BERC-POLYMAT), Dr. Eva Sanchez can translate all the expertise acquired about the innovative fields of 3D and 4D bioprinting to Europe, where there is a clear need.

Keywords: nir sensitive biodegradable hydrogels