Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
End-to-end web platform for the design and implementation of Industrial Control Systems (Wonderlogix STUDIO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-07-01
End date: 2020-12-31
Duration (months): 30.0
Total project cost (EUR): 2774000.0
EU funding (EUR): 1941800.0
Participants: 1
Project status: CLOSED

Industrial manufacturers (2.4 million in Europe) claim to be losing 25% of product sales’ value due to unnecessary factory-floor industrial process quality control. Low quality in industrial processes brings long-term cost increase due to non-optimal utilization of industrial equipment, and is a trigger for costly and undesirable downtime and plant-floor incidents. Programming environments for automation systems are decades away from the likes of similar technologies employed by other industries. This lack of updated resources, causes engineers to lose control over the different factors that have an impact on the final quality of the resulting processes that eventually run at plant-floor. WonderLogix Studio is an end-to-end environment for industrial process design, simulation and PLC programming. It aims at streamlining the way in which Automated Control Systems are developed, by a combination of Model-Driven Engineering, code generation and cloud computing, in an all-in-one environment that overcomes the high segmentation of technologies in the market for design and control software development, reducing up to 3 times the high cost of commissioning. WonderLogix Ltd. was founded in 2015 by 2 engineers with more than 20 years together designing and implementing control systems. Our patented solution has been run in a range of pilot projects at real industrial facilities that received highly positive feedback, and the support from several private and public investors and grants. We have developed a distribution and partnership network that will support market launch, with 6 distributors, 9 system integrators and 6 pilots engaged, and the support from the world leading PLC vendor. This project will let us to accumulate a €8.8M net profit in 5 years, consolidate our brand, and create 17 new jobs. The scalability of our business model guarantees the accomplishment of these objectives only by capturing 3,235 users (<1% of the market share).

Keywords: industrial automation,software,code generation,model driven engineering,programmable logic controller,control software
Fibroblasts in the Biology of Rectal Cancer Progression (FiBRO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Although the therapeutic strategies adopted in the last years for the clinical management of patients with rectal cancer have improved patient’s quality of life, tumor relapse still constitutes to be a factor that determines patient survival. These patients, usually treated with chemo-radiotherapy (CRT), often develop a CRT-induced fibrosis, which is characterized by an overgrowth of fibroblasts at tumor-treated areas. The importance of tumor stroma for the development, progression and invasion of cancer is increasingly gaining weight, however, the biological basis of fibrosis, as well as the consequences that it has in terms of therapy resistance and tumor relapse remain unknown. The major objective of this proposal is to understand the effect of CRT on fibroblasts and its consequences on tumor relapse and formation of distant metastasis. To reach this, we propose a multidisciplinary approach that combines the analysis of unique patient-derived biological samples using innovative and advanced techniques in molecular and cell biology. More specifically, using a proteomic approach and primary cultures of fibroblasts derived from rectal tumors taken before and after CRT from the same patient, we will determine the effect of CRT on the molecular alterations in fibroblasts. Then, using 3D in vitro models we will determine if CRT-derived fibroblasts play a role in therapy resistance, proliferation and invasion of cancer cells, while ortothopic mouse models will be used to test if CRT-derived fibroblasts can trigger rectal cancer progression and metastasis. Finally, using previously collected clinical data of rectal cancer patients we will analyze if tumor relapse is related to the appearance of fibrosis and, if it has a positive or negative prognosis value Altogether, the results expected from this project will improve basic biological knowledge of fibrosis-development, and will provide with new clinical tools to improve patient welfare.

Keywords: cancer microenvironment,cancer associated fibroblasts,fibrosis,recurrence,metastasis
The evolutionary and ecological implications of mito-nuclear epistasis (MITONUC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

The main hypothesis of the proposed research is that, contrary to common and long-standing belief, mitochondrial genetic variation is functional and plays a key role in evolutionary adaptation. I suggest that a novel understanding of selection on mtDNA can derive from simultaneously considering sex-specific selection and genetic interactions between mtDNA and nDNA. Because males are a genetic “dead-end” for mtDNA, mtDNA mutations that are detrimental for males but beneficial for females will spread. This will generate a male-specific genetic load (“the mother’s curse”). Further, the main energy producing pathway in eukaryotes (the OXPHOS pathway) is built collectively by products of the mitochondrial and the nuclear genome. Thus, mtDNA and nDNA are potentially entangled in an intricate web of epistatic interactions that dictates organismal metabolism. The proposed research is built upon a series of interrelated parts, and will use a very amenable insect model organism and employ a range of different research methodologies. Specific aims of the proposed research is (1) to assess the effects of mito-nuclear genotype on key life history traits such as metabolic rate and test whether these effects are sex-specific in line with the “mother’s curse” and (2) to test the hypothesis that mito-nuclear interactions promotes the maintenance of polymorphism in mitochondrial genome through negative frequency dependent selection. This research will have a range of biological implications, ranging from applied medical genetics over our use of mitochondrial genetic markers in population genetics/biology to speciation and our understanding of thermal adaptation to climate change.

Keywords: mtdna variability,mito nuclear episastasis,metabolic rate,fitness
Self-driven INTramedullary bonE Regeneration: Development of a SINTER nail for bone reconstruction (SINTER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

As a Maria Skłodowska-Curie Fellow, I aim to develop a self-driven bone transport nail to reconstruct large bone defects caused after trauma or tumour removal. This is to overcome the current limitations of bone transport techniques that use intramedullary nails. These are: daily involvement of patients during the distraction process, regular interventions by surgeons and the significant cost of the procedure. These limitations have led to limited use of this method regardless of its superior outcomes compared to other commonly used techniques. It is becoming more popular now as it overcomes limitations of external fixators: a prolonged treatment time, diligent care, as well as psychological, hygiene, and daily activity burden for patients and caregivers. Automating the process and reducing its cost, can considerably promote the use of the nails. Under the supervision of Prof. Anthony Bull, a world leader in translational low-cost medical devices and musculoskeletal biomechanics at Imperial College London, I aim to overcome this translational barrier by developing a novel distraction mechanism. I will optimise the nail using a spring-piston system to achieve the optimised distraction rate for bone reconstruction. The unique design of the nails allows manufacturing by traditional processes as well as additive manufacturing. Given the type of trauma and tumour, the defect could be developed at different places in the bone. Therefore, surgical and technical considerations will be taken into account in collaboration with Mr Craig Gerrand and Mr Pierluigi Cuomo, world leaders in bone cancer/transport surgery, during a secondment at the Royal National Orthopaedic Hospital. This project will develop the first self-driven intramedullary nail for bone transport. This nail is not only advantageous compared to the available ones but also a low-cost option that can make this technique more affordable and available worldwide, particularly in Low- and Middle-Income Countries.

Keywords: medical devices,bone reconstruction,bone transport,intramedullary nail
ImmunoPET directed to specific subtypes of GABAA receptors as strategy for molecular mapping of behaviour and mental illness (GABARPET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-09
End date: 2023-09-08
Duration (months): 36.0
Total project cost (EUR): 304021.44
EU funding (EUR): 304021.44
Participants: 1
Project status: SIGNED

Changes in GABA receptors are known hallmarks for numerous neurological diseases including schizophrenia which is a severe psychiatric disorder that has a profound effect on both the individuals affected and society. The diagnosis of schizophrenia is complex because of the loss of high specific biomarkers. Research papers have suggested that the differential expression of GABAA receptors in the brain is associated with this mental disease. The current evidence on GABAergic abnormalities in schizophrenia is mostly based on postmortem studies and, in this sense, in vivo measurements of GABAA receptor subunits can reveal additional insights. This project will develop Positron Emission Tomography (PET) probes which could unveil quantitative information about GABAA receptor expression in schizophrenia patients. However, the lack of imaging tracers with high affinity and specificity do not shed a clear light on the diagnosis in a traditional PET setting. In this sense, the immune-positron emission tomography (immunoPET) is a non-invasive technology based in antibody imaging which reveals a specific and sensitive molecular characterization of the cell surface phenotype in vivo. Nevertheless, its success in neuroimage is limited because of intact antibodies cannot penetrate the Brain Blood Barrier (BBB) in healthy conditions. However, GABARPET will tap into a small recombinant bispecific antibody construct targeting the GABAA receptors as well as the transferrin receptor because it is able to readily transmigrate across the BBB in vivo after peripheral injection. This project wants to develop di-single-chain variable fragment (di-scFv) directed to α1 and α2 subunits of GABAA receptors. Then, they will be labeled with conventional radionuclides produced by cyclotron as 18F and 89Zr. ImmunoPET probes will be used in wild-type mice, GABAA receptor knockout mice and different kind of rodent models of schizophrenia.

Keywords: gabaa receptors,schizophrenia,immunopet,blood brain barrier,electrophysiology,pharmacology,antibody engineering,molecular biology,radiochemistry,single chain variable fragment
HEALTHCARE ALLIANCE FOR RESOURCEFUL MEDICINES OFFENSIVE AGAINST NEOPLASMS IN HEMATOLOGY – PLUS (HARMONY PLUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Germany,Germany,Germany,Germany,Germany,Spain,Italy,Italy,Germany,Spain,Italy,Germany,Germany,Spain,Spain,Spain,Finland,Switzerland,Switzerland,Belgium,Belgium,France,France,Czechia,Netherlands,United States,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Restricted Call to maximise impact of IMI2 JU objectives and scientific priorities (H2020-JTI-IMI2-2019-19-single-stage, 2019)
Start date: 2020-10-01
End date: 2024-03-31
Duration (months): 42.0
Total project cost (EUR): 12012669.0
EU funding (EUR): 6715625.0
Participants: 43
Project status: SIGNED

Haematological malignancies (HM), also known as blood cancers, are a heterogeneous and complex group of multicausal diseases that can’t be easily diagnosed nor treated. Nowadays most treatments are extremely complex, and advances in patient diagnosis and therapies slow due to the low number of patients per centre. Thus, there is a need to harmonise, store, and analyse the current HM information to speed-up and support the decision-making process for patients’ access to new therapies. HARMONY PLUS takes advantage of the capabilities of the HARMONY Big Data platform to match these unmet needs by expanding its scope to incorporate myeloproliferative neoplasms, including chronic myeloid leukemia, polycythaemia vera, essential thrombocythaemia, and myelofibrosis; and lymphoproliferative disorders, including Hodgkin’s lymphoma, Waldenström macroglobulinemia and all the other rare HMs not covered by HARMONY Project. In parallel, HARMONY PLUS will continue to refine and define the Core Outcome Sets (COS), especially for these new HMs to ensure the use by researchers of useful common outcomes relevant to all stakeholders. As previously accomplished in HARMONY, HARMONY PLUS is committed to pursue the maximum ethical and legal requirements, particularly to ensure patient’s right to privacy. Data-driven research within Europe will be enhanced by converting the current HARMONY platform into an Integrated Services Platform to serve as a valuable tool to support clinical trial design and use of available data as a control arm. This platform, combined with a HaemoDatabank repository with information about HMs patient biological samples across Europe, will facilitate a more efficient research and clinical trial design, and consequently will promote collaborations with recognised databases outside Europe. From the regulatory point of view, HARMONY PLUS will be a valuable technology tool during the evaluation of new treatments and drugs by also considering the patients’ needs.

Keywords: haematology,oncology,molecular genetics,business model,digital health outcome,big data,data analysis,translational medicine,myeloproliferative disorders,lymphoproliferative disorders,rare hm
Statistical Mechanics and transport phenomena in Active Colloidal Solids (StaMACS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: SIGNED

The objective of StaMACS is to uncover the dynamics of an active and loosely packed magnetic colloidal crystal. This system will consist of repulsive paramagnetic particles immersed in a bath of light-driven bacteria. We will have two independent ways to tune the interactions: 1) An external magnetic field will control the strength of the dipolar repulsion between colloids. 2) The intensity of light will control the motility of bacteria and thus the particle’s induced activity, both locally and globally. By combining experiments with simulations and theoretical analysis, we will reach a general understanding of this system’s dynamics, study its melting and crystallization transitions and examine how a local change in activity propagates throughout the crystal. Our findings will unveil the properties of a novel out-of-equilibrium system: an active colloidal solid. Furthermore, this work will stimulate theoretical investigation related to the kinetics of such systems, with strong implications on understanding the fundamental process of crystallization in the presence of activity. By a two-way transfer of knowledge, StaMACS will bring numerous mutual benefits to both the researcher and the host institution. Its results will represent a major contribution to the soft and active matter field with direct applications in physics, biology and material science. Descriptors: Active Matter, Soft Matter, Statistical Mechanics, Magnetic Colloids

Keywords: active matter,soft matter,statistical mechanics,magnetic colloids
Mortality Risk Attributable to Thermal Discomfort Indicators with Implications of Climate Change (MORDIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

A rapidly growing body of studies attribute mortality outcomes to thermal exposures, by empirically estimating reduced-form mortality responses to meteorological fields, usually ambient temperature. The research theme proposed in this project is motivated by the awareness that the human thermoregulatory system is a function of not just ambient temperature, but also other environmental parameters such as humidity, radiant temperature and wind. Correct characterization of the environment-related mortality relationship is vital not just in epidemiology, but also for climate-health impacts assessment, understanding the burden on health services, and the potential spill overs to labour productivity and the wider economy. This project will attribute mortality risk to multiple thermal stressors not previously examined in epidemiology and the wider climate-health impacts studies. The project will apply innovative approaches and for the first time, a comprehensive suite of thermal discomfort indicators, both under present climate and contrasting future socio-economic/climate scenarios. The transdisciplinary nature of the project requiring knowledge and training in subjects such as biostatistics, environmental epidemiology, human biometeorology, big data and climate modelling; will involve two-way transfer of knowledge between the researcher and the host institute. Results have the potential to: (i) improve the data and modelling approaches applied in existing environment-related morality studies at a global scale; (ii) facilitate better understanding of the population’s adaptive capacity to thermal exposures, accounting for age and gender; (iii) inform future public health responses at various national/international scales, such as urban planning, healthcare services, and investments in energy-health adaptation; and (iv) assist in government initiated National Adaptation Programmes. The project is in line with the broader EU strategy for ‘Climate, Environment and Health’.

Keywords: climate change and health,human discomfort indices and mortality
Construction of Self-Dividing Protocells (CSDP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Artificial cells are synthetic compartments that are able to mimic one or more properties of natural cells and provide valuable avenues for the study of fundamental cellular functions. However, thus far there are no examples of synthetic systems/materials that can achieve self-replication. Therefore the key aim of this project is to create artificial self-dividing protocells. I will build a platform that combines synthetic chemistry, cell biology and microfluidics to prepare cell-like systems. Monodisperse picoliter multiple all-aqueous droplet systems (e.g., liposomes) generated by microfluidics will be utilized to construct self-dividing protocells. To achieve division, the so-called Z-ring of the bacterial divisome will be incorporated in droplets, together with an energy-generation system. I have extensive experience in microfluidics research and especially in the preparation of multiple emulsions with complex compartments, which I will exploit in this project. At Radboud University (RU), I will obtain new skills and expertise in biochemistry and biology such as in vitro gene expression, chemical reaction networks, and bottom-up synthetic biology. Importantly, the reconstitution of an artificial cell divisome would lead to a deeper understanding of the biophysical principles of cellular behavior and will be the most fundamental step towards construction of artificial cells. I believe this in vitro reconstituted system provides a revolutionary new platform for biomimetic research.

Keywords: artificial cells,self dividing protocells,multiple emulsion,droplet microfluidics,all aqueous droplet systemms,liposomes,z ring,in vitro generation of gtp,bottom up synthetic biology