Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Geo-acoustic mapping of benthic habitat distribution (GEO-HABIT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-05-01
End date: 2014-04-30
Duration (months): 24.0
Total project cost (EUR): 278807.4
EU funding (EUR): 278807.4
Participants: 1
Project status: CLOSED

It is widely recognized that important efforts must be done towards the protection and preservation of the Deep-Sea environments, which are increasingly threatened by human impacts (e.g.: trawl fishing and marine pollution). These efforts imply a further knowledge of the spatial organization of benthic communities in Deep-Sea and an implementation of efficient and cost-saving mapping methods. GEO-HABIT is a multidisciplinary project that will focus on a holistic study of the relationship between seafloor geology and biodiversity patterns. Important insights are expected on the role that physical elements play in the distribution of Deep-Sea habitats and in the development of an integrated and nested-scale method to map them. Data mainly consist of geo-acoustic data (high-resolution Multibeam bathymetry and Sidescan Sonar), HD videos from ROV (Victor6000-IFREMER) and Manned-Submersible (Jago-GEOMAR) and rock/sediment seafloor samples. The study will focus on geomorphic features (Submarine canyons, Seamounts) which are benthic ecosystem hot-spots due to their specific environmental settings and which, according to the European Community, potentially deserve site protection (European Habitats Directive), thus indicating the timeliness and relevance of the project. With the support of researchers from NOC (National Oceanographic Centre), with a long-standing expertise in the fields of habitat mapping, biotic and abiotic characters of the seafloor will be analyzed, classified and mapped at unprecedented detail through the use of cutting-edge geophysical instrumentation and their functional relationships will be explored through multivariate statistical analysis. As a second step, new methods based on geo-spatial analysis will be developed in order to derive statistically robust predictive models of benthic habitat distribution, with relevant impact for the conservation of biodiversity and science-based management strategies of natural resources.

Keywords: natural sciences,habitat mapping,geophysical methodologies,predictive analysis,technological sciences
the Physics of Acoustic Materials (PAM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-07-01
End date: 2014-12-31
Duration (months): 24.0
Total project cost (EUR): 235000.0
EU funding (EUR): 235000.0
Participants: 1
Project status: CLOSED

This project is directed towards material research of acoustic poro-visco elastic materials with the aim to improve physical insight into the acoustic behavior of materials. The project has the following objectives 1. Development of fast and robust methods for material characterization 2. Development of physical models for poro-visco elastic materials. Material characterization of porous materials is a renowned field of expertise of the host, the Laboratory for Acoustics and Thermal Physics at K.U.Leuven, headed by Prof Glorieux. For the characterization of acoustic materials new innovative measurement concepts will be explored. These new measurement concepts involve the Nearfield Acoustic Holography (NAH) and Acoustic Radiation Force (ARF) techniques. The aim of using these new measurement concepts is to estimate poro-visco elastic material properties faster and in a robust manner. For the physical modeling collaboration will be set up with the group of Prof. Desmet at K.U.Leuven, to develop Wave Based numerical models and confront the numerical model results with experimental results. Whilst the fellow up till now had combined jobs at both industry and university, it is the fellow’s ambition is to enter into fulltime employment as a full professor at a European university. The fellow’s training objectives are all centered around this ambition. The Marie Curie IEF-program offers the fellow the possibility to work for 2 years fulltime in an internationally oriented research group that has a world-class reputation in the field of acoustics of poro-visco elastic materials and vibro-acoustic modeling, allowing him to gain experience with all aspects of leadership of an internally working academic research group.

Keywords: technological sciences,vibration engineering,acoustics
Molecular mechanisms of ion channels voltage-dependency (MECAVDEP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2012-08-01
End date: 2014-07-31
Duration (months): 24.0
Total project cost (EUR): 158469.65
EU funding (EUR): 158469.65
Participants: 1
Project status: CLOSED

Voltage-gated ion channels are ubiquitously expressed in human tissues where they play diverse physiological functions such as the generation and modulation of the electrical activity in excitable tissues, myocyte contraction, modulation of neurotransmitter and hormone release. Mutations and/or altered regulation of these channels are associated to many pathologies such as neuronal, cardiac and muscular diseases. As a result, structural and functional characterization of those channels will certainly lead to new pharmacological, genetic and cellular therapies. Crystallization of voltage-gated potassium (Kv) and sodium (Nav) channels provided a lot of information on their structure, and represented a new template for investigations on their molecular characteristics. This allowed us to shed light on the molecular mechanism of a cardiac Kv and a skeletal muscle Nav channel voltage-dependency. We showed that the channel protein contains an intramolecular ligand (the linker between the fourth and the fifth transmembrane domain, S4-S5) that binds to the channel gate (S6) and locks it in a closed state, in a voltage-dependent fashion. This channel property allowed us constructing inhibitory S4-S5 peptides and activatory S6 peptides. We now want to test if the channels regulation by S4-S5 and S6 peptides may be of therapeutical interest, first in the context of cardiac and skeletal muscle pathologies. First we will study the structural details of the S4-S5/S6 interaction to improve the peptides efficacy. This will be done with the help of different molecular and structural tools that are available in the laboratory of Dan Minor: Nuclear Magnetic Resonance, isothermal titration calorimetry, circular dichroism…Second we will develop in vivo tests to validate the peptides therapeutical interest. More generally, this project will help me in reinforcing the competitiveness of the group in “biophysics to bedside” studies.

Keywords: health sciences,cardiology,physiology,rare diseases
Definition of the chemical and immunological characteristics of flucloxacillin-induced liver injury (CHIC-FILI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-09-01
End date: 2013-08-31
Duration (months): 12.0
Total project cost (EUR): 139403.7
EU funding (EUR): 139403.7
Participants: 1
Project status: CLOSED

Immunological reactions represent one of the most feared adverse drug events; they cannot be predicted and show no simple dose-response relationship. The presence of drug-response T-lymphocytes in patients with cutaneous reactions provides a robust case for their involvement in the disease pathogenesis. In contrast, the role of T-cells in reactions targeting the liver is less well defined. We have recently defined the profile of drug protein conjugation at specific amino acid residues with respect to dose and incubation time and characterized the minimum levels of modification associated with the stimulation of T-cells. We now aim to utilize these methods to characterize the cellular response in patients with flucloxacillin-induced liver injury. Drug antigens will be characterized by mass spectrometry and used to define the phenotype (CD, homing receptors) and function (Th1, Th2, Th17 & cytotoxicity) of antigen-specific T-lymphocytes and T-cell clones. Recently, an association between expression of HLA-B*5701 and flucloxacillin-induced liver injury has been described, which implies a direct effect of the gene product on the disease pathogenesis. To explore whether susceptibility relates to the restriction of the fit of the drug antigen in MHC, we will utilize our unique cell bank of HLA-typed healthy volunteers and a novel in vitro assay to relate phenotype to function and to investigate the additional signals that might be required to convert an antigenic signal into an aberrant T-cell response. The Fellow will be trained in bioanalytical and cell culture methods that are directly applicable to immunological drug reactions. Furthermore, the Liverpool CDSS and the Ajou School of Medicine will establish a collaboration to transfer clinical samples to investigate other HLA associations in different ethnic groups. This will allow us to respond in real-time to newly identified genetic variants associated with adverse reactions

Keywords: drug-induced liver injury,t-lymphocyte,antigenicity,immunogenecity
Microbial Biomarker Records in Tibetan Peats: Monsoon Variability and its Impact on Methane Biogeochemistry (TIBETMETH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-08-01
End date: 2014-07-31
Duration (months): 24.0
Total project cost (EUR): 278807.4
EU funding (EUR): 278807.4
Participants: 1
Project status: CLOSED

It is crucial to understand terrestrial microbial processes because they govern greenhouse gas emissions; unfortunately, the long-term microbial responses to climate change remain unclear, causing uncertainty in predictions for how they will impact future climate and atmospheric composition. The peatlands from the Tibetan Plateau, controlled by the Indian Monsoon and East Asian Monsoon systems, have been major players in climate change and carbon cycling, such that these deposits represent a truly novel potential to address the above scientific issues. This proposed research will expand the Tibetan Plateau dataset of peat-forming plant δD values, a key hydrological indicator; quantify and isotopically characterise microbial biomarkers and especially those derived from organisms involved with methane cycling; evaluate the link between precipitation, vegetation, redox conditions and microbially mediated processes and especially methanogenesis. These records will be developed using cutting edge approaches exploiting gas chromatography (GC), GC-mass spectrometry, high performance liquid chromatography-mass spectrometry, GC-isotope ratio mass spectrometry (IRMS) and GC-thermal conversion-IRMS. This dataset seeks to understand methanogenic and methanotrophic processes and will be used to develop higher resolution and longer-term CH4 biogeochemical records over the Holocene and to better understand the effect of Asian monsoon change on modern and ancient CH4 biogeochemistry, and to ultimately embed them in the framework of known and hypothesised relationships between microorganisms and climate change. This work will be one of the very first applications of these novel methodologies to the study of past changes in peat biogeochemistry outside of Northern Europe. It will validate and expand on the European investigations and contribute to a better mechanistic understanding of the microbial response to climate change and its impact on CH4 biogeochemistry.

Keywords: asian monsoon variability,ch4 biogeochemistry,the tibetan peatland,microbial biomarkers,the holocene
Interactions between polarons in polarized Fermi gases (INTERPOL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-03-01
End date: 2014-02-28
Duration (months): 24.0
Total project cost (EUR): 193594.8
EU funding (EUR): 193594.8
Participants: 1
Project status: CLOSED

In this application, we propose to study the physics of the polaronic gas. In a spin imbalanced Fermi gas, that is with a larger number of spin up particles than with spin down, the usual Cooper pairing scenario no longer applies, and this raises the question of the possible phases of the system. It was recently proposed by C. Lobo et. al. [PRL 97, 200403 (2006)], that in the strong imbalanced regime the minority atoms dressed by the Fermi sea of the majority atoms form a weakly interacting gas of quasi-particles called polarons. Whereas the basic one-body properties of these polarons seem to be quite well understood the interaction between polarons is still a debated issue, but crucial in order to understand the many-body properties of the polaronic gas. We therefore propose to study the polaronic interaction problem in homogeneous polarized Fermi gases, and its extension to optical lattices. We will tackle the problem in two different ways: (i) directly addresses the scattering problem of two finite momentum polarons with a variational approach, or with a Green’s function approach, (ii) addresses the many-body properties of the polaronic gas assuming that the p-wave scattering volume of two polarons is obtained from the first step.. Allowing the applicant to be hosted at the ENS (Paris), would give him the possibility to work in a different geographical and working environment from the one in which he has already worked before. The excellence of the host institution, which has been playing at international level a leader in the experiments on strongly interacting fermions, and in the theory of polarons, together with the vanguard of the project, provide the fellow with a good training, and open the way to a position of professional maturity.

Keywords: physical sciences,condensed matter properties,statistical physics
Ecological conditions underlying the lack of lipid synthesis in parasitic insects (ECOLOGY&LIPOGENESIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-09-01
End date: 2015-12-21
Duration (months): 24.0
Total project cost (EUR): 193594.8
EU funding (EUR): 193594.8
Participants: 1
Project status: CLOSED

All organisms invest in nutrient storage to fuel energetic requirements needed for survival and reproduction. The consistency with which organisms invest in nutrient storage, in particular lipids, makes it remarkable that numerous parasitic insects lack lipid synthesis. The parasitic larval lifestyle adopted by these parasitoids has facilitated a means to carry over valuable resources from their host and allows them to refrain from costly investment in storage reserves. The lack of lipogenesis has thus evolved concurrently with that of the parasitic lifestyle in insects. However, several parasitoids deviate from this pattern, in which lipogenesis is recurring, suggesting that ecological conditions rather than evolutionary adaptations may underlie the lack of this trait. I propose to explore how ecological conditions affect the lack of lipogenesis in parasitoids, and the costs and benefits associated with this strategy. I will determine how nutritional conditions affect gene transcription and nutrient dynamics in two species of parasitic wasp differing in their propensity for lipogenesis. Biological systems will be experimentally pushed to switch their lipogenic strategy using flight to increase energy-demand and the ecological setting necessary to maintain lack of lipogenesis as a successful strategy will be determined using a modeling approach. This integrative study will be the first to identify the causal link between the molecular and physiological mechanisms and the ecological conditions that underlie the lack of an essential metabolic trait in parasitic insects. It will provide important insights into how shifts in metabolic regulation occur and function, and help to unravel how and when organisms can survive while lacking a metabolic trait that is crucial for survival and reproduction in all other organisms.

Keywords: natural sciences,lack of lipogenesis,nutritional ecology,parasitoids,nutrient metabolism,metabolic regulation,gene transcription,fitness,modeling
Peptide Sensing Platforms for proteins and antibodies detection (PSP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2012-06-30
End date: 2014-06-29
Duration (months): 24.0
Total project cost (EUR): 247840.1
EU funding (EUR): 247840.1
Participants: 1
Project status: CLOSED

The present fellowship proposal aims to give the applicant a strong expertise in peptide folding and peptide based sensors. This objective will be reached through a scientific project focused on the development and optimization of a novel, rapid, point-of-care method for the simultaneous detection of multiple diagnostic proteins. The approach, which will utilize electrochemistry to monitor the binding-induced folding of peptide/polypeptide used as recognition elements, will be rapid, specific, convenient and, critically, selective enough to be employed directly in blood serum and -we propose- whole blood. Through a multidisciplinary and complementary approach the fellow will be trained in protein and peptide folding, a field fundamental to develop the proposed biosensor platform. Training on peptide labeling with redox tags and on formation of peptide films on different sensor surfaces will be also exploited during the fellowship in order to achieve the final research objectives. Outgoing and return host institutions have both the required expertise for these training and scientific objectives. In particular, the outgoing host, Prof. Plaxco lab at UCSB, USA, has a unique strong expertise on both peptide/protein folding and electrochemical sensors. The outcome of the fellowship will be crucial for the applicant’s future career and will not only strengthen his scientific knowledge but also his communication and didactic know-how. Moreover, the peptide sensors developed could be of strong impact for the scientific excellence of European Community.

Keywords: clinical chemistry,clinical analysis,electrochemistry,surface chemistry
Metamodelling of dynamic models of the heart (METAMODELLING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-01-01
End date: 2013-12-31
Duration (months): 12.0
Total project cost (EUR): 104516.7
EU funding (EUR): 104516.7
Participants: 1
Project status: CLOSED

Mathematical modelling of biological systems facilitates a deeper understanding of organ function and disease mechanisms. However, biophysically based models have a complex structure, are computationally demanding and extremely difficult to validate, and comparison of competing models is very challenging. These characteristics seriously delay progress in the use of modelling in sciences such as systems biology and medicine, and as the application of models to both large basic science data sets and in clinical context progresses these issues will become increasingly important. The aim of the proposed project is to reduce these bottlenecks using metamodelling, i.e. generation of statistical approximations of model input-output mappings. The objectives are to 1) reduce computational demand of multi-scale spatiotemporal heart models by substitution of parts of the models with statistical approximations, 2) establish a robust platform for global high-dimensional sensitivity analysis (analysis of the impact of the various input parameters on the model outputs) based on metamodels, enabling more efficient model validation, and 3) develop metamodel-based methodology for model construction and validation through systematic comparison and assessment of the prediction spaces of different models and comparison of models to experimental data. We will build a flexible metamodelling framework based on multivariate regression, adapted to handling the high parameter- and state space- dimensionality characterising multi-scale models. The fellowship will have a large impact on integration of metamodelling into the modelling community due to the central role that the host group has in e.g. the FP7-funded Virtual Physiological Human project. The methodology will be generic and highly instrumental in the development and testing of complex models, and has the potential to make a major impact not only within the modelling community but also across both experimental and clinical sciences.

Keywords: computational biology,applied biology,applied mathematics,modelling tools,computational models,biomathematics,statistics