Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The compact LIBS module for advanced materials analysis (Colibri)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Netherlands
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2015-01-01
End date: 2015-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Anteryon BV has a track record of more than 30 years in the R&D, manufacturing and marketing of refractive optical components and modules for a variety of niche market applications. Since 2010, Anteryon has been expanding in providing customized optical solutions for compact optical encoders and spectrometers. As a next step in this roadmap Anteryon envisages to accomplish a breakthrough in user access, size and cost reduction of a fast growing spectroscopic materials analysis technique, namely Laser-Induced Breakdown Spectroscopy (LIBS). The name Colibri stands for compact LIBS module for advanced materials. The novel Colibri module is carrier for a breakthrough in LIBS and will enable a more efficient, affordable, and more wide-spread use this spectroscopic technology for the analysis of materials. In this way, the increased use of LIBS will also contribute to the social themes and to the efficiency in executing European programs in the field of waste management, environmental protection, ecological footprint reduction, food safety control and health care. The Colibri module is a novel architecture and manufacturing platform that will be available as a standard plug-in module for compact, cost-effective, robust reconfigurable and user accessible spectrometers. The proposed Colibri module satisfies spectrometer users needs to measure in real-time and in-line without compromising the LIBS spectral accuracy and at affordable costs (at least 4 times lower than the state of the art). The Colibri module allows reconfiguration of the spectrometer for different applications by adapting software only. These features will boost the user accessibility and market size of affordable LIBS technology. The feasibility assessment under Phase 1 will include a business plan including marketing plan, optimal price definition, funding strategies, technical feasibility, fabrication process, capital equipment, cost analysis, an IPR study and a risk and sensitivity analysis.

Keywords: spectrometry,material analysis,segmented grating,waste,food safety,modular,real time,fit for use
Combining constrained based learning and transfer learning to facilitate Zero-training Brain-Computer Interfacing (ZERO-TRAIN-BCI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Brain-Computer Interfaces (BCI) enable the user to control a computer or external device directly through his or her brain signals. This interface can be used for restoring communication for completely paralysed patients, to restore motor function through prostheses but also for non-medical applications such as gaming. The initial BCI prototypes relied on voluntary modulation of the brain signals to control the computer. Nowadays, it is the computer that is taught via machine learning algorithms how to interpret the brain signals and this reduced the training times to 15-30 minutes for a calibration session. During such a calibration session, the user is instructed to perform specific mental tasks, such that the recorded brain signals can be labelled with the user’s intention. This labelled data-set is then used to train the machine learning algorithm. Unfortunately, due to non-stationarity in the observed brain signals, re-calibration is often required to ensure the accuracy of the interface. Obviously, frequent (re-)calibration is not desired. Especially for patients with a limited attention span, it must be reduced to a minimum. The BCI community has invested much effort in reducing the need for calibration data. However, despite this effort, true zero-training BCIs that do not require calibration are rather rare. For the Event Related Potential (ERP) based BCI, we were able to develop such a true zero-training BCI based on the concepts of constraint based learning and transfer learning. That decoder was designed specifically for the ERP based BCI and cannot be ported directly to other paradigms. Hence, the goal in this project is to expand on this idea and to develop a true-zero training Motor Imagery (MI) based BCI by investigating novel machine learning methods based on constraint based learning and transfer learning.

Keywords: machine learning,brain computer interface,motor imagery
Real-time analysis of ribosomal frameshifting and its impact on immunity and disease (T-FRAME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1499852.0
EU funding (EUR): 1499852.0
Participants: 1
Project status: SIGNED

The coding region of many genes contains sequence elements that constitute roadblocks during mRNA translation. These roadblocks present problems, but also opportunities for the cell to increase the coding capacity of the genome by so-called programmed ribosome frameshifting (PRF). PRF is a universal gene expression strategy that brings plasticity to the proteome. It is widely studied in viruses and bacteria, yet poorly understood in humans. My own mechanistic discoveries have highlighted that, regardless of various stimulatory structures and slippery nucleotides involved, PRF in bacterial and viral mRNAs follows one of the two general pathways depending on substrate. In contrast, many questions remain regarding the occurrences of PRF in humans and its regulation by recently discovered trans-acting viral and cellular factors. In T-FRAME, I will investigate the mechanism of PRF and its role in disease using HIV infection of human-T lymphocytes as an in vivo paradigm. To study molecular details of how trans-factors modulate PRF, I will leverage cutting-edge ensemble and single-molecule techniques to monitor the ribosome as it moves along the mRNA codon per codon. In addition, I will assess mRNA interactions with PRF factors during this process. Using a PRF-RNA-interactome capture assay that we have recently developed, I will search for new trans- factors in human cells. Finally, I will study the translation of T cells and HIV-1 on a global level during infection to understand the full scope and dynamic nature of PRF in this model system. To summarize, T-FRAME will advance our understanding of how RNA structure and trans-factors shape translation regimes in higher eukaryotes and how deviations from the standard decoding path impact infection and innate immunity. I envision harnessing these findings to develop novel tools for synthetic biology and new design principles for RNA-centric antiviral and immune therapies.

Keywords: mechanisms of infections,immunity,frameshifting,translation,hiv 1,recoding
Overcoming plant graft incompatibility by modifying signalling and perception (GRASP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-08-01
End date: 2024-07-31
Duration (months): 60.0
Total project cost (EUR): 1499902.0
EU funding (EUR): 1499902.0
Participants: 1
Project status: SIGNED

For millennia, people have cut and joined together different plants through a process known as grafting. Plants tissues from different genotypes fuse, vasculature connects and a chimeric organism forms that combines desirable characteristics from different plants such as high yields or disease resistance. However, plants can only be grafted to closely related species and in some instances, they cannot be grafted to themselves. This phenomenon is referred to as graft incompatibility and the mechanistic basis is completely unknown. Our previous work on graft formation in Arabidopsis thaliana has uncovered genes that rapidly activate in grafted tissues to signal the presence of adjoining tissue and initiate a vascular reconnection process. These genes activate around the cut only during graft formation and present a powerful tool to screen large numbers of chemicals and genes that could promote tissue perception and vascular formation. With these sensors and our previously established grafting tools in the model plant Arabidopsis, we can address fundamental questions about grafting biology that have direct relevance to improving graft formation through: 1. Identifying genes required for the recognition response using forward and reverse genetic screens. 2. Determining and characterising signals that activate vascular induction using a chemical genetics screen. 3. Characterising the transcriptional basis for compatibility and incompatibility by analysing tissues and species that graft and comparing these to tissues and species that do not graft. 4. Overcoming graft incompatibility and improving graft formation by applying the knowledge obtained from the three previous objectives. We thus aim to broaden our fundamental understanding of the processes associated with grafting including wound healing, vascular formation and tissue regeneration, while at the same time, use this information to improve graft formation and expand the range of grafted species.

Keywords: plant grafting,vascular formation,developmental biology,arabidopsis thaliana,tomato,maize,self,non self recognition
Local quantum operations achieved through the motion of spins (LOQO-MOTIONS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-02-01
End date: 2023-07-31
Duration (months): 66.0
Total project cost (EUR): 2264167.0
EU funding (EUR): 2264167.0
Participants: 1
Project status: SIGNED

Spins have long been appreciated as versatile tools for studying coherent quantum phenomena in a range of materials and have emerged as powerful components for the development of technologies such as quantum information processors and sensors. Results from the past 5 years have shown that spins can exhibit exceptionally long coherence lifetimes (seconds for the electron spin, hours for the nuclear spin), and can be measured with high fidelity in a single shot and at the single spin level. These achievements provide strong motivation to address what remains an open challenge: how to controllably couple such coherent spins in a scalable manner. This goal is being vigorously pursued by many groups following approaches such as those based on exchange interactions between spins, or coupling spins to optical or microwave photons and measurement-based entanglement. However, each of these approaches carries formidable challenges and a clearly realisable route to a scalable technology is still currently lacking. The aim of LOQO-MOTIONS is to exploit the long coherence times observed in spins of atomic defects in materials and open up a new approach for coupling spins based on dipolar interactions combined with physical motion to achieve local quantum operations. This approach is inspired by a recent blueprint for the implementation of a surface code using donors in silicon, permitting fault-tolerant operation even with the limited positional accuracy of ion implantation. LOQO-MOTIONS assembles a comprehensive set of tools required to explore and exploit physically mobile spins, including: versatile single- donor spin measurement, coupling of donor spins and optically-addressable defect spins, and cryogenic scanning of probe spins over static spins to generate entanglement. In addition to developing a new platform for engineering spin-spin couplings, LOQO-MOTIONS has strong synergies with spin-based magnetometry and nano-scale quantum sensing applications will be explored.
Mission-Oriented SwafS to Advance Innovation through Co-creation (MOSAIC)

Framework: Horizon 2020 — Science with and for Society
Action type: Research and Innovation actions
Countries involved: Italy,Belgium,France,France
Call: Bottom-up approach to build SwafS knowledge base (H2020-SwafS-2020-1, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 1138000.0
EU funding (EUR): 1138000.0
Participants: 7
Project status: SIGNED

While most SwafS initiatives have contributed to strengthening knowledge and approaches to Open Science, few initiatives have explored and implemented an RRI approach to Open Innovation. MOSAIC will address this SwafS knowledge base gap, exploring how to translate the involvement of stakeholders “from all parts of the quadruple helix”, typical of SwafS and RRI, in Open Innovation ecosystems, within the context of a mission-like environment focused on climate neutral and smart cities priorities. Drawing upon the richness of SwafS experiences so far, MOSAIC’s research will lead to the assessment of effective instruments applicable to successful co-creation approaches in quadruple-helix Open Innovation pathways. While doing so, the MOSAIC consortium will define and assess indicators to measure impacts and transformative changes that are specific to this particular context, generating scientific publications as well as toolkits to be further used within future SwafS-like initiatives and beyond. Pilot actions in the cities of Brussels and Milan will test MOSAIC’s methodological approach and research actions throughout the project. The piloting process will produce concrete instruments and recommendations, to be replicated in further European cities and regions willing to engage in mission-oriented approaches via quadruple helix collaboration, but also to enrich the work of Horizon Europe researchers and stakeholders more broadly.

Keywords: co creation,swafs,quadruple helix,open innovation
Combinatorial aspects of Heegaard Floer homology for knots and links (MM-CAHF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Hungary
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 139850.88
EU funding (EUR): 139850.88
Participants: 1
Project status: SIGNED

The action's goal is to achieve major advances in Heegaard Floer homology for knots and links. Heegaard Floer homology is a package of powerful invariants for 3-manifolds, and knots and links inside them. Introduced two decades ago, it is now a major research area in low-dimensional topology. To a knot or link in the 3-sphere, together with extra data called `decoration', Heegaard Floer homology associates a bigraded vector space which determines key topological properties of such a knot or link, such as its Alexander polynomial and its Seifert genus. Moreover, given a (decorated) link cobordism between two links, there is a linear map induced between their Heegaard Floer homology. The original definition of Heegaard Floer homology is based on counting pseudo-holomorphic curves in symplectic manifolds, but there exist combinatorial reformulations of the vector spaces associated to decorated knots and links. The proposal consists of three major projects: 1) Give a combinatorial reformulation of the Heegaard Floer cobordism maps, to make their computation algorithmic, by extending existing combinatorial definitions of the vector spaces associated to decorated knots and links. 2) Extend the most efficient combinatorial reformulation, namely the Kauffman-states functor, from decorated knots to decorated links. 3) Define a combinatorial Heegaard Floer invariant for partially decorated links, for which attempts to give an analytic definition seems unfeasible.

Keywords: heegaard floer homology,knot floer homology,link floer homology,kauffman states functor,link cobordisms,cobordism maps,sutured manifolds
Evolution of Cognitive Tools for Quantification (QUANTA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Norway,France,United States,United Kingdom
Call: ERC Synergy Grant (ERC-2020-SyG, 2020)
Start date: 2021-09-01
End date: 2027-08-31
Duration (months): 72.0
Total project cost (EUR): 9900025.0
EU funding (EUR): 9900025.0
Participants: 5
Project status: SIGNED

Exact quantification, including the ability to count, depends on both conceptual breakthroughs and cognitive tools such as numeral systems. These tools appear in striking diversity across cultures and manifest in different modalities (verbal, body-based, written, or material). To address the tantalizing questions of when, why, and how they emerged and evolved, we test two previously untestable key hypotheses: that conceptual breakthroughs and tools co-evolved, with different modalities coactively scaffolding the breakthroughs; and that the tools diversified in response to changing cultural requirements. Reconstructing this evolution is the prime goal of QUANTA. Addressing its ambitious objectives requires an unprecedented synergetic combination of (i) archaeological, ethnographic, and linguistic insights into numeral systems worldwide, including prehistoric artefacts and symbols, and on contemporary contexts in which quantification occurs and changes; (ii) a cognitive framework for deriving evolutionary hypotheses from system properties; (iii) powerful computational (phylogenetic) methods for testing these hypotheses and thereby reconstructing cultural evolution; and (iv) innovative means to substantially extend the temporal scope of these methods into the past, to include the first attested instances of quantification. To achieve this goal, QUANTA brings together four leading PIs with unique and complementary expertise in exactly these means. By integrating an evolutionary approach with a cognitive perspective on quantification, QUANTA will transform this research field. Its novel strategy will, for the first time ever, yield substantiated insights into the emergence and evolution of numeral systems, thus advancing our understanding of human cognition and its dependence on cultural tools. While the highly interdisciplinary, multi-method approach renders this a high-risk project, QUANTA has the potential to bridge the gap between previously incommensurable fields.

Keywords: numbers,language,and mind,evolutionary anthropology,cultural evolution,phylogenetics,numerical cognition and culture,numeral systems,diversification of languages,distributed cognition,cognitive evolution,prehistory,quantification,counting devices,experimental archaeology,history of writing,notational systems
Intra- and Inter-Areal Communication in Primate Brain Networks (In2PrimateBrains)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Italy,Germany,Germany,Greece,Belgium,France,France,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 4005134.64
EU funding (EUR): 4005134.6399999997
Participants: 11
Project status: SIGNED

In2PrimateBrains proposes a highly competitive training-through-research program dedicated to the study of neuronal intra- and inter-areal communication in non-human primate (NHP) brains. This program will empower the next generation of researchers with best practices and cutting edge methodologies for studying complex neuronal activity from multiple brain areas and across cortical layers. Our core scientific goals are to identify common and specific bottom-up and top-down communication principles across NHP brain networks for vision, motor control and executive functions. These functions are especially well developed in primates, and we propose to study them in a brain model as close as possible to the human brain: the NHP brain. Critically, detailed insights into the local- and long-range dynamics of communication, down to the single-neuron level and at millisecond precision, necessitate invasive recording, stimulation and inactivation techniques precluding human investigations. The project entails 9 work packages with well-defined tasks to ensure success in our research and training objectives. We propose tailored research training by world-leading European researchers from the academic, clinical and industrial sectors. This will be accompanied by a comprehensive program of network-wide training events including thematic workshops in essential research-related skills and soft-skill training sessions to ensure successful careers in public or private sectors. The direct experience and acquired expertise in state-of-the-art NHP research and technology development in different environments will drive our ESRs to pursue international, interdisciplinary and intersectoral careers. In a highly competitive international environment, In2PrimateBrains will ensure that Europe remains at the forefront of primate brain research in health and disease with scientists trained by the highest scientific, methodological and ethical standards.

Keywords: non human primate,brain,integrative neuroscience,translational research,clinical models,brain dysfunctions,pathologies,pre clinical,complex cognitive functions,intersectoral,ethics