Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Defect passivation for two-dimensional (2D) magnetic semiconductors (Defect M)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-12-18
End date: 2027-12-17
Duration (months): 24.0
Total project cost (EUR): 236340.0
EU funding (EUR): 236340.0
Participants: 1
Project status: SIGNED

The unique integration of magnetic and semiconducting properties in 2D magnetic semiconductors opens new opportunities for controlling charge and spin degrees of freedom, crucial for developing advanced spin-based technologies. Among these materials, 2D van der Waals CrSBr stands out due to its strong coupling between magnetic and electronic structures. However, the unexplored passivation strategies and unclear defect mechanisms hinder its advancement for nanoscale opto-spintronic devices. Defect M is designed to establish innovative chemical passivation methodologies to achieve high-quality and stable 2D CrSBr with a comprehensive understanding of defect physics, which not only allows us to gain a better understanding of the degradation mechanism but is also critical to enable reliable studies of spin- and charge-based phenomena. This highly interdisciplinary project facing key future technologies will pave the way for next-generation spin-based devices and benefit the upcoming EU's priorities of digital transformation and green transition.

Keywords: 2d magnetic semiconductors,defect passivation,synchrotron radiation,ultrafast optical spectroscopy
Integrated Optomechanical Nanoresonators for Real-Time Single-Molecule Detection Thorugh Photothermal Spectroscopy (IONR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-05-15
End date: 2027-05-14
Duration (months): 24.0
Total project cost (EUR): 183600.96
EU funding (EUR): 183600.96
Participants: 1
Project status: SIGNED

Optical absorption microscopy based on the photothermal heating effect has recently succeeded in detecting single molecules with a temperature-sensitive nanomechanical resonator. Molecules are sampled onto the nanomechanical resonator and probed with a free-space laser. Upon scanning, optical absorption and photothermal heating of the sample results in a detectable detuning in the mechanical resonance frequency. This technique has overcome the main limitations of alternative optical probing methods. A remaining challenge of nanomechanical photothermal microscopy is the alignment of the free-space optics with the intersecting molecular sample beam necessary to perform time-resolved single-molecule spectroscopy. Furthermore, off-plane optics limits its possibility to be miniaturized. Integrating NIR/MIR waveguides in nanomechanical resonators will create an innovative optomechanical device that solves the alignment problem, increases the field of view, decreases optical complexity, and enables photothermal spectroscopy miniaturization avoiding absorption spectroscopy limitations (i.e.Fabry-Perot resonances, outcoupling, and propagation losses). We propose to give the first steps towards a complete integrated photothermal spectroscopic device for single-molecule analysis dispensing with free-space optics. In the envisioned design, the probing light travels inside the nanomechanical resonator, orthogonal to the sample beam, resulting in an evanescent interaction with the sample molecules on the surface. This design will enable the detection of single-molecule deposition events from heterogenous samples, in particular, airborne particles and proteins in solution will be the target analyte due to its environmental and health relevance. Furthermore, the selectivity provided by the spectroscopic measurement allows for identifying and monitoring neoplastic, while the device holds potential use for early diagnostics.

Keywords: nanomechanical resonators,integrated photonics,single molecule detection,photothermal spectroscopy
FeDerated nEtwork of pLatforms for Passenger and freigHt Intermodality (DELPHI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Countries involved: Greece,Cyprus,Ireland,Belgium,Spain,Romania,Switzerland,Germany
Call: Smart enforcement for resilient, sustainable and more efficient transport operations (HORIZON-CL5-2022-D6-02, 2022)
Start date: 2023-07-01
End date: 2026-06-30
Duration (months): 36.0
Total project cost (EUR): 4999561.5
EU funding (EUR): 4999561.5
Participants: 18
Project status: SIGNED

Growing challenges are identified during the last years in both passenger and freight mobility, such as urbanization trends, the increasing complexity of stakeholder scene, e-commerce, rising fragmentation of freight transport. Despite the various technical challenges and shortcomings, current governance and regulatory systems have proven so far inadequate, dealing with the passengers and freight transport systems as independent -and thus disconnected- sectors while integration between passenger and freight transport has been a subject of debate in the transport community over the last years with a peak coming after the recent Covid19 crisis. DELPHI focuses on the strategic dimension of integrating passenger and freight transport in a single system aiming to deliver the enablers -both on technical and governance/regulatory level, towards a federated network of platforms for multimodal passenger and freight transport, capable of sharing in a seamless and secure manner, cross-sectoral, multi-modal passenger and freight transport data, as well as traffic management systems information. Moreover, DELPHI will utilise novel and ultra-efficient methodologies for traffic monitoring such as UAS-powered monitoring, multi-/inter-modal optimisation, AI/ML-powered algorithms and frameworks, and will exploit diverse modes for hybrid passenger and freight transport in different ecosystem types. To achieve its maximum potential, utmost interoperability and best optimisation results, DELPHI’s digital framework and transversal tools will be validated in the context of 4 pilots with complementary requirements and features.

Keywords: governance,federated network of platforms,data federation,inter modal optimisation
Personalizing virtual brains with neurodegenerative disease: noninvasive stimulation approach (PINGED)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: SIGNED

Tracking of individual progression trajectory of neurodegenerative brain disease such as Alzheimer's disease (AD) can enable targeted interventions to prolong active living with increased quality of life and substantially reduce the socioeconomic burden. Approaches based on mechanistic modeling have the capacity to integrate heterogeneous data and capture the inter-individual variability, but their application in the case of AD is challenging due to non-idetifiability of relevant parameters from spontaneous brain activity. This project will use the recently developed technology for noninvasive brain stimulation - the temporal interference - to address the key question: is the response to stimulation sufficiently informative to allow estimation of the model parameters reflecting the position of an individual along the AD progression trajectory. The main objective of this project is to develop and validate a proof-of-concept of a brain health status estimation workflow informed by both the response to targeted non-invasive stimulation (TI) and the resting state dynamics (fMRI), while leveraging the personalized model-based inference. The project will advance along following main axes: systematic analysis of parameter identifiability using both stimulation and resting state paradigms, development of a personalization workflow combining structural data, resting state fMRI and the TI, and evaluation of model inversion performance using response to different stimulation targets. The results of the project have the potential to pioneer personalized mechanistic model inversion in the context of AD, and to pave the way for further development of the AD monitoring workflows which can be adapted in routine health screening practices.

Keywords: noninvasive brain stimulation,neurodegenrative disease,virtual brain modeling,disease trajectory,alzheimer s disease
Origin, evolution and function of bacterial extracellular vesicles in the human host-gut microbiome system (VESICULOME)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1999423.0
EU funding (EUR): 1999423.0
Participants: 2
Project status: SIGNED

Bacterial extracellular vesicles (BEVs) are small membrane vesicles secreted by a diverse range of bacteria that act as bioactive nanocarriers of a high diversity of proteins, lipids and nucleic acids. BEVs have mostly been studied in pathogenic bacterial models, owing to their causal role in pathogenicity. Compared to other microbial features, such as taxa, genes or metabolites, BEVs secreted by the large diversity of commensal bacterial species of the human gut microbiota have received little attention so far, leaving their influence upon gut microbial ecology and human health almost entirely unknown. We hypothesize that gut BEVs and their molecular cargos (i.e. the gut bacterial vesiculome) play critical roles in bacteria-bacteria and host-microbiome interactions, and in shaping phenotypes of host-microbiome systems. Our project will enable a comprehensive profiling of BEV molecular diversity across a large number of gut bacterial taxa, and a functional analysis of their impact on inter-species and inter-kingdom interactions. We intend to tackle these objectives through three aims: 1) characterize the origin, diversity and evolution of the human gut bacterial vesiculome; 2) investigate the role of BEVs in promoting horizontal gene transfers among bacterial species in the gut microbiome; and 3) investigate the role of BEVs on bacteria-bacteria and host-bacteria interactions. We will tackle each of these aims from three diversity perspectives: investigating multiple bacterial species, including geographically-distinct healthy human populations, and comparing healthy vs. disease. The project will expand our basic understanding of the evolution and function of bacterial vesiculation. It will also generate the first atlas of BEV profiles across gut bacterial taxa and host cohorts, providing key resources to mine for vesicular characteristics and functions that have translational potential for biomedicine.
The molecular suite of shell Bio- & ArCHaeochromes (BACH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Lithuania,Denmark,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 142757.76
EU funding (EUR): 142757.76
Participants: 3
Project status: SIGNED

Molluscs adorn their shells with an incredible diversity of colours and patterns which were highly appreciated since ancient times. Shell biochromes encode important biological information - they may play a role in immunity, shell strengthening, protection from thermal stress and UV radiation. They are also extremely durable in time – pigments can be found in fossil shells dating to millions of years. Could shell biochromes be among the most promising ancient biomolecules? Despite the great diversity and complexity of shell colours, there is no complete molecular understanding of shell pigmentation in any mollusc system. The studies are limited and our knowledge how biochromes are mineralised (not to mention how they preserve) remains patchy. BAch will carry out an in-depth study of mollusc shell biochromes. The work will focus on a model species Littorina fabalis which displays colour polymorphism and are abundantly found in archaeological record, since they were used in prehistory. I will employ cutting-edge ‘ShellOmic’ techniques - transcriptomics and proteomics, coupled with the first application of CRISPR-Cas9 gene editing tool to elucidate the chemical nature of shell biochromes and associated proteins. Gene editing will help to verify genes that are involved in shell coloration and biomineralisation. The research and training will provide me with a novel set of skills reinforcing my position as an expert shell research. Finally, I will use palaeoproteomics, the analysis of ancient proteins by mass spectrometry techniques, to investigate the preservation potential of ancient biochromes, i.e. archaeochromes. In the future, we could use these as biomolecular colour markers to answer archaeological questions. BAch will address decades long query – what are the shell pigments and what biological information do they encode? My unique expertise, multidisciplinary network, international background and expert team on board will guide me to answer these questions.

Keywords: mollusc shells gene editing shell proteomics,mollusc transcriptomics,shell pigments,palaeoproteomics,archaeological shells
The PUPILLO tracker: next generation eye tracking (PUPILLO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Denmark
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-03-01
End date: 2026-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Eye-tracking is one of the most valuable tools for measuring human behaviour, applicable to multiple populations and stages of development, and their use has enjoyed an exponential increase both within and outside of research. Pupil size, measurable with eye-trackers, provides a valuable index of a wide range of cognitive functions. However, pupillometry has significant untapped potential because current commercial eye-trackers are unable to provide reliable indications of cognitively driven pupil changes. This results in a restricted design space for research, large loss of data and often unreliable measurement. We propose a novel architecture of remote eye-tracker for behavioural research, conceived to address both the problem of large data loss, and the problem of reliability of pupil size changes. Our solution addresses these pains at both the hardware and software levels, with a series of innovations including an identical offline mode to retrieve otherwise lost data, and autofocus and robotic tracking to accommodate much greater participant movement. In pilot experiments, with infants, we have increased the proportion of usable data from about 50% with the current state of the art, to close to 100%. We are currently developing procedures and algorithms to compensate for the light reflex so that pupil dynamics data is deconfounded, and acquisition possible over a much larger span of stimuli and situations. PUPILLO aims to become the next generation eye-tracker, providing the research and medical communities and beyond, with a cost-effective, easy-to-use and customizable solution to fully exploit the potential of gaze tracking and pupillometry.
BE READY NOW - EUROPEAN PARTNERSHIP FOR PANDEMIC PREPAREDNESS (BE READY NOW)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: COFUND actions
Partnership: Pandemic Preparedness (co-funded)
Countries involved: France,Austria,Belgium,Bulgaria,Czechia,Germany,Denmark,Finland,Greece,Hungary,Ireland,Italy,Lithuania,Luxembourg,Netherlands,New Zealand,Norway,Poland,Portugal,Sweden,Spain,Türkiye,Ukraine,United Kingdom,Estonia,Slovakia,Moldova, Republic of
Call: European partnership for pandemic preparedness (HORIZON-HLTH-2024-DISEASE-12, 2024)
Start date: 2026-01-01
End date: 2032-12-31
Duration (months): 84.0
Total project cost (EUR): 118328575.79
EU funding (EUR): 57281202.18
Participants: 81
Project status: SIGNED

BE READY NOW aims to implement the European Partnership for Pandemic Preparedness. This Partnership will gather 74 organisations from 24 countries, including public funding agencies, public health institutes, clinical networks, ministries and research infrastructures active in pandemic preparedness. This consortium is aligned around the vision of building a European research and innovation ecosystem optimally prepared for future health crises caused by infectious diseases, therefore contributing to the objectives of the European Research Area (ERA). To achieve its ambitious vision, BE READY NOW will align stakeholders in pandemic preparedness around shared research priorities to foster a coordinated and efficient research landscape, producing sustainable scientific, health, and socio-economic benefits. Through Joint Transnational Calls, BE READY NOW will help close critical research gaps covering the whole spectrum of pandemic preparedness research (including basic research, diagnostics, therapeutics, vaccines, and public health interventions), through an interdisciplinary approach. It will therefore directly address the goals of Horizon Europe’s Cluster 1 Health. Building on the infrastructures, projects and initiatives supported by the European Commission and Member States, BE READY NOW will establish and sustain an "ever-warm" research ecosystem, capable of pivoting swiftly in response to emerging health threats. This ecosystem will include an innovative, ever-warm EU-wide network of networks of clinical research sites. In the longer term, BE READY NOW will improve the EU's capacity in the areas of prevention, preparedness, surveillance, risk assessment and response to infectious diseases, ensuring the international visibility of the EU as a recognised actor for pandemic preparedness research and response, and providing resilience for citizens and health systems beyond the Partnership’s duration.

Keywords: medical countermeasures,one health,pandemic,ever warm,readiness,sria,randi,fair data,jtc,coordination of research,basic,pre clinical,clinical implementation research,integrated approach
Educating Europe`s Future Engineers for the Next Generation of Mobile Working Machines: AI driven Sustainability, Productivity, and Safety (ENGAGE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Finland,Germany,Sweden,Austria
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 5113893.5
EU funding (EUR): 3975066.72
Participants: 17
Project status: SIGNED

Mobile working machines (MWM) are ubiquitous in mining, construction, harbours, forestry, and farming, and without doubts vital for economic and industrial advancement of our society and as such key to sustainability and productivity of our society. Ambitious goals for sustainability, productivity, and safety, coupled with a shortage of human resources, have prompted the European mobile working machines ecosystem to come together in proposing this innovative network of Industrial Doctorates. ENGAGE network will train a new generation of engineers to build next generation mobile working machines for green and autonomous operations. Key European machine manufacturers (Volvo CE, Liebherr, Ponsse, AGCO), and technology suppliers (Bosch Rexroth, Bosch, Novatron, Algoryx, GIM Robotics) have joined forces with 6 academic groups highly specialised in AI, robotics, and mechanics from Finland, Germany, Sweden, and Austria to deliver ENGAGE. Europe’s MWM industry needs to invest heavily in digitalization, ‘green’ and innovative technologies. Thus, there is a rapidly growing demand for experts: who possess a holistic overview of the trends in sustainability and safety; have an understanding of the challenges and opportunities that robotics and AI can bring; and who are trained within certain disciplines such as robotics and AI (control, computer science, signal processing), machinery (safety, mechanical engineering, simulation, optimization), domain knowledge (construction, logistics, forestry, agriculture, mining), and big trends (digitalization, sustainability, responsible AI). ENGAGE will address these needs and fill the gap related research and training.

Keywords: mobile working machines,non road mobile machines,construction,mining,agriculture,forestry,automation,safety