Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
NUmerical investigation of LAndslides and tsunamis in CANary Islands (NULACAN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: SIGNED

Landslides induced by volcanic activity can lead to deadly tsunamis. The urgency of developing effective hazard and risk assessments for landslides and tsunamis is highlighted by past tragic events. Nonetheless, specific guidelines for risk assessment concerning landslides and tsunamis are currently lacking. Landslide tsunamis can be triggered by submarine or subaerial landslides. However, the complex multiphase and multiphysics dynamics of landslides interacting with the ocean lead to a large number of uncertainties that diminish our capacity to quantify the risk associated with potential landslides and the subsequent tsunamis. Thus, the goal of this project is to reduce the uncertainties in landslide modeling, water/landslide interactions, and tsunami generation. This pioneer research intends to improve the accuracy of future probabilistic tsunami hazard assessments in the Canary Islands. The project comprises two phases: The first phase of the project investigates submarine landslides and their turbidity currents to gain insights into deposit shapes and triggering mechanisms. Numerical simulations will be conducted to study the evolution of the seabed during volcanic eruptions and the potential mechanisms that enhance landslide mobility. The second phase focuses on subaerial landslides, considering the interaction of air, water, and soil. More specifically, the project aims to accurately predict the energy transfer from landslides to wave generation. Different numerical approaches, including discrete element method, finite volume method, and depth-averaged equations will be used to provide a comprehensive analysis of landslide dynamics from local to large scales. Through a case study using real field data, the project will validate a multiscale numerical approach and mitigate the current knowledge gaps, paving the way for a future probabilistic tsunami hazard assessment of the Canary Islands.

Keywords: granular flows,numerical methods,multiphase flows,landslides,tsunamis
DigiShares – RealEstate.Exchange (DS.REX)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 2433462.5
EU funding (EUR): 2433462.5
Participants: 1
Project status: SIGNED

DigiShares - RealEstate.Exchange DigiShares will create the only regulated exchange in Europe for real estate known as RealEstate.Exchange (REX) which focusses specifically on giving the real-estate sector the necessary innovation and improvement. The mission of DigiShares is to democratize access to real estate as an investment object in order to create equal opportunity among "rich" and “poor” and in the long-term help close the European and Global wealth gap. REX is a platform, managed by DigiShares, where primary offerings and secondary trading allows investors to increase or exit their positions, capitalize on market opportunities, and provides flexibility in managing their real estate investments. DigiShares will act as the stewards for tokenization of the housing market and serve as an example for other projects wishing to follow suit. As the creator of REX, DigiShares has built more than 150 white-label solutions, allowing shares of real estate companies to be digitized and issued as security tokens on the blockchain. It is in a strong position since it meets the necessary legal and compliance requirements for operating in the region, and helps to build trust in the system. In addition, REX will be the first real estate exchange to comply with the EU distributed ledger technology (DLT) Regime. The requested grant is €2,433,462.50. This represents 70% of the total costs €3,476,375.00. The remaining €1,042,912.50 will be covered by a combination of Debt, Equity and revenues from the project to ensure the successful scaling of the innovation.The real estate industry is keen to work with DigiShares. To date, DigiShares has 150+ customers who have signed NDA’s, spread across 40+ countries. This represents between €500 and €1bn in AUM. Overall, the REX platform will provide equal access to good investment opportunities and contribute to closing the global wealth gap.

Keywords: real estate,tokenization,blockchain,regulated exchange
The geometrical and physical basis of cell-like functionality (CellGeom)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2498813.0
EU funding (EUR): 2498813.0
Participants: 1
Project status: SIGNED

Can systems with life-like properties be built from scratch with only a minimal set of components? While progress has been made experimentally in the development of such minimal systems, there is a lack of theoretical underpinnings that could provide mechanistic principles. My goal is to discover such principles by combining theoretical modeling and in-silico evolution to explore the potential for life-like functions of minimal systems consisting of only two core elements of cells: reaction compartments enclosed by lipid membranes (liposomes) and equipped with a protein reaction network. Towards this goal, we will develop new multi-scale approaches to investigate the mechanistic interplay between the ability of protein networks to form spatiotemporal patterns by decoding information about the membrane geometry and to reshape the membrane through mechano-chemical feedback. Using methods from differential geometry we will develop projection techniques that reduce the model to the two-dimensional manifold of the membrane. Building on my expertise with protein pattern formation I will design coarse-graining methods using machine learning concepts to link scales. These theories will give unprecedented insights into the relative role of reaction networks, membrane elasticity, and mechanochemical feedback in forming different types of protein patterns and membrane morphologies. Moreover, they will provide an efficient computational platform, which I will use to in-silico explore the potential of supported lipid bilayers with adhering liposomes as a platform to generate functions such as cell migration, cell division, and collective cell-cell communication. This will lead to theoretical insights into the mechanistic principles of the emergent behavior of these systems, make specific predictions for established bottom-up experimental model systems, and provide innovative suggestions for the rational design of systems with targeted functionalities.

Keywords: theoretical physics,nonequilibrium dynamics,self organization,cell membranes,protein pattern formation,continuum field theory,model reduction and coarse graining,evolutionary algorithms,numerical simulations
Development of an innovative GPM for the ZEPHYR microlauncher (ZEPHYR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-12-01
End date: 2026-11-30
Duration (months): 24.0
Total project cost (EUR): 3567500.0
EU funding (EUR): 2497250.0
Participants: 1
Project status: SIGNED

Latitude, a French launcher company, ambitions to become a world leading end-to-end space access provider, by developing and operating a dedicated micro-launcher called “Zephyr”. Zephyr is a launch vehicle which will be able to place small satellites of up to 200 kg in a Low Earth Orbit. This launch solution is expected to be nimble, reliable, reactive, and affordable to allow small satellites to embark on their own dedicated micro launcher. The cornerstone of these services is Zephyr, powered by an in-house designed rocket engine, Navier and an innovative low-cost launchpad system which allows an easy rescheduling, launching from several launchpads without launchpad-specific design, and therefore scale economies.

Keywords: ground means
F-POINT: AN INNOVATIVE POINT-OF-CARE DIAGNOSTIC FOR OPTIMAL TREATMENT OF MASSIVE HAEMORRHAGE (F-point)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 18.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

xPoint Diagnostics aims to bring point-of-care diagnostics to clinicians, enabling them to provide optimal treatment to patients suffering from massive haemorrhage. Globally, over 5 million people die of massive haemorrhage, of which an astonishing 20% of deaths could be prevented with existing treatment options if they were administered adequately. During bleeding, coagulation pathways are activated to form a blood clot to stop a bleed. The final step in coagulation is the conversion of fibrinogen to fibrin which form the fibres of the clot. In severe bleeding, which can occur in trauma or post partum haemorrhage, the fibrinogen can be used up, preventing blood clot formation. Therefore, it is vital for patient survival, that fibrinogen is replaced as soon as fibrinogen levels in the patient drop. To facilitate timely, precision guided fibrinogen replacement therapy, repeated monitoring of patient fibrinogen levels is required. Unfortunately, current gold-standard fibrinogen diagnostics are too slow (~1h from sample collection to result), preventing clinicians to give patients the optimal care to save their lives. To address this need, xPoint Diagnostics has developed F-point: an easy-to-use microfluidics-based point-of-care fibrinogen diagnostic that measures fibrinogen at gold standard accuracy within <7 minutes from sample collection to result. F-point, enables clinicians to easily monitor fibrinogen levels and to provide treatment adequately, improving patient outcomes and saving lives. Clinicians treating trauma and postpartum haemorrhage patients indicate eagerness to adopt F-point. Furthermore, Roche is interested in a distribution partnership when F-point is closer to market. To further develop F-point towards a commercial product, we request a grant support of €2.5M from EIC. With this support, we will finalize the design and conduct a clinical performance test, reaching our next milestone: a finalized product ready for clinical trials.

Keywords: diagnostic medical device,point of care,haemorrhage
Engineering Catalytic Membraneless Organelles for CO2 Fixation (ECOFix)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2025-04-30
Duration (months): 18.0
Total project cost (EUR): 130385.52
EU funding (EUR): 130385.52
Participants: 1
Project status: CLOSED

In recent years, membraneless organelles were shown to be intracellular liquid like condensates formed through phase separation. Following their discovery, they have been found across all kingdoms of life. For some of these organelles, a crucial role in cellular physiology has been determined, while for many others their true function remains unresolved. Recently, it has also emerged that the pyrenoid, which concentrates the CO2 fixation machinery of photosynthesis, behaves like a liquid non-membrane bound organelle in green algae. However, the pyrenoid and its forming protein EPYC1 undergo a complicated assembly in vivo, which poses a challenge for the functional understanding, engineering and transplantation of pyrenoids. Here I propose to use a bottom-up strategy to assemble and evolve pyrenoid formation de novo. To paraphrase the renowned physicist Richard Feynman – “What I cannot create, I do not understand” – I plan to mimic the formation of pyrenoids by fusing liquid-liquid phase separating (LLPS) intrinsically disordered peptides (IDP) to RuBisCO to create artificial pyrenoid-like condensates in vitro (objective 1). From the RuBisCO-IDP library, I will select the best performing condensate for transplanting into S. elongatus to generate an artificial pyrenoid. Subsequently, I will compare this strain with the wild-type and a carboxysome knock-out strain (objective 2). Finally, I will evolve the RuBisCO-IDP and the corresponding strain for enhanced photosynthesis (objective 3). My experiments will inform on the evolutionary differences between different carbon concentrating mechanisms (CCM), on the biochemical mechanisms underlying a liquid-liquid phase separated CCM and will show whether and how CCMs can be engineered towards improved photosynthesis. This project will lay the basis to realize strategies for increased CO2 uptake in phototrophs, thereby providing new options for a carbon-neutral bioeconomy and improved food productivity in the future.

Keywords: carbon fixation,membraneless organelles,rubisco,intrinsically disordered proteins peptides,metabolic engineering,phototrophs,cyanobacteria
CENTRE FOR DATA ENRICHED MEDICINE (TEAMPERMED) (TeamPerMed)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Estonia,Netherlands,Finland
Call: Teaming for Excellence (HORIZON-WIDERA-2022-ACCESS-01-two-stage, 2022)
Start date: 2023-09-01
End date: 2029-08-31
Duration (months): 72.0
Total project cost (EUR): 15000000.0
EU funding (EUR): 15000000.0
Participants: 11
Project status: SIGNED

Using advanced experience, medical research progress, and international know-how, the TeamPerMed project empowers the University of Tartu together with Tartu University Hospital to form the independent Centre for Personalised Medicine - TeamPerMed. This Center of Excellence (CoE) will become a multi-disciplinary unit integrating expertise in Genomics, IT, Clinical Medicine, and Socio-Economic Analysis. It will create a scalable framework for developing clinical guidelines and clinical decision support (CDS) tools that can be effectively integrated into EU healthcare systems. With the guidance from the leading expert partners, Erasmus Medical Centre and the University of Helsinki, a vibrant network of associated stakeholders, and the support of EC and the Republic of Estonia, TeamPerMed will become a recognized regional/EU leader in translating genomic and electronic health data to prevent the development of chronic or hereditary disease and offering high-quality personalized medical care. TeamPerMed will stimulate digital transformation in healthcare by using available databases and electronic health records to develop AI tools and protocols effective for prevention/early identification of individual health risks and their consecutive treatment. TeamPerMed CoE intellectual outputs including technology, tools, knowledge, and innovative healthcare practices, will boost Estonia’s and Europe’s competitiveness in the emerging personalised medicine sector, improving the quality of healthcare, prolonging longevity and maximizing health of European citizens, and bringing the advantages of future digital medicine to our citizens already today. The TeamPerMed Center will become an internationally recognized leader in the areas of personalized medicine and customized healthcare contributing directly to a better physical and mental wellbeing and indirectly to social and spiritual wellness, opening the door to a more harmonious society and paving the way for the ‘next generation

Keywords: personalised medicine,genomics,clinical medicine,clinical decision support tools,health data
Sensing Microbial Activities Related To Harmful Algae Blooms (SmartHAB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-06-16
End date: 2028-06-15
Duration (months): 36.0
Total project cost (EUR): 285140.64
EU funding (EUR): 285140.64
Participants: 2
Project status: SIGNED

Harmful algal blooms (HABs) impair water quality and ecosystem health, therefore the EU Water Framework Directive requires water management authorities to establish comprehensive monitoring programs in water bodies at risk. Traditional hand-held sampling provides limited temporal and spatial resolution that generates large uncertainties for decision making and hinders responsiveness of contingency plans. The SmartHAB project will advance emerging automatic high-frequency monitoring (AHFM) systems to improve the forecasting of HABs through data-driven modeling and real-time decision making. Microbial electrochemical sensors (MESs) capable of detecting microbial interactions during HABs episodes will be developed. This novel approach exploits the overlooked role of microbial communities in the promotion and termination of HABs as forecasting model tool. The fellow will conduct a multidisciplinary methodology at Arizona State University (USA) to (i) design and develop low-cost and low-maintenance biosensors and characterize the interface between electroactive bacterial biofilms (EABs) and the electrode; (ii) design and develop a multimodule AHFM platform with biosensors to collect massive water quality data that, after processing through machine leaning/artificial intelligence (ML/AI) tools, will allow to correlate the electrical fingerprints with HAB-related processes; and (iii) understand the sensitivity of the biosensor to microbial community shifts. All this knowledge will be transferred to IMDEA Water (Spain-EU), where (iv) the ability of biosensors to identify specific events related to HABs will be enhanced by constructing tailored biofilms on electrodes through an innovative 3D-printing technique. Overall, this project will allow the fellow to gain experience and a set of skills to reach a future position of maturity, while advancing scientific knowledge in the framework of EU policies on adaptation to climate change and digitization of water resources.

Keywords: harmful algae blooms,cyanobacteria,eutrophication,biosensors,microbial interaction,monitoring,biofilms,electroactive bacteria,3d printing,scanning electrochemical microscopy,digitalization
Wellbeing and Employability for Youths with Psychosocial Disabilities through Digital Technologies (WAYSIDE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Kenya
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2025-05-31
Duration (months): 36.0
Total project cost (EUR): 281970.72
EU funding (EUR): 281970.72
Participants: 2
Project status: CLOSED

Psychosocial disability (PD) refers to ‘disabilities that arise from barriers to social participation experienced by people who have or who are perceived to have mental conditions or problems’ According to the World Health Organization, mental, neurological and substance use disorders (MNS) account for more than 10% of the global disease burden of disease and are responsible for 1 in 5 years lived with disability. The global loss of productivity on account of depression and anxiety is estimated to cost the global economy US$1 trillion each year. In low- and middle- income countries, more than 75% of people with MNS receive no treatment at all for their disorder. In Kenya, unmet need for mental health services (MHS) is worse in young persons compared to adults. Further, poverty and adversities are causes and consequences of poor mental health and persons with PD experience discrimination in mental health service, employment, and social life that affect wellbeing and life expectancy. Mental health services in Kenya are sparse and elude most persons with PD. Access to available MHS is limited by lack of information about where and how to access it, and discriminatory delivery of services. In recognition of the dire need for inclusive mental health services, a recent interagency Government of Kenya Taskforce on Mental Health in 2021 declared mental ill-health in Kenyan society as a national public health emergency. Also, strengthening the Mental Health system is the fourth strategic objective of the Kenya Mental Health Action plan 2021-2025. This project responds to this need (identified by GOK taskforce) and aligns with the WHO’s vision of a world where ‘all people achieve the highest standard of mental health and well-being’. The overall aim of this project is to develop and pilot a support framework for an inclusive mental health system using digital technologies to promote wellbeing, work, and employment for young persons with PD in Kenya.

Keywords: wellbeing,work and employment,psychosocial disabilities,inclusive mental health system,digital technologies