Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Commoditizing Data Analytics in the Cloud (CODAC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-02-01
End date: 2028-01-31
Duration (months): 60.0
Total project cost (EUR): 1498125.0
EU funding (EUR): 1498125.0
Participants: 1
Project status: SIGNED

The goal of this project is to commoditize large-scale data analytics in the cloud, which means (a) to reduce query processing cost to close to what the available hardware is theoretically capable of and (b) to prevent vendor lock-in by making it easy to move data between different clouds and systems. To achieve this, we will design and develop an open and cost-efficient analytical database system for the cloud called CODAC. The CODAC system consists of three main components: First, an intelligent control component that automatically and transparently selects and manages the cheapest hardware instances for the given workload and makes migration to other (e.g., European) cloud vendors possible. Second, a highly-efficient and scalable query processing engine that is capable of fully exploiting modern cloud hardware. Third, a data lake storage abstraction based on open data formats that enables cheap storage as well as modularity and interoperability across different data systems. The resulting system therefore has the potential for making large-scale data analytics both cheaper and easier, boosting data-driven instruct and science.

Keywords: cloud,cost efficiency,data analytics,query processing,data management
CorrelAtes of Protective immuniTy-driven Investigation of malaria VAccine combinaTion stratEgies (CAPTIVATE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Belgium,Norway,Netherlands,Germany,Australia,Czechia
Call: Vaccines 2.0 - developing the next generation of vaccines (HORIZON-HLTH-2022-DISEASE-06-two-stage, 2022)
Start date: 2023-11-01
End date: 2028-04-30
Duration (months): 54.0
Total project cost (EUR): 8725948.0
EU funding (EUR): 8725948.0
Participants: 9
Project status: SIGNED

Malaria remains a serious health concern worldwide, with P. falciparum considered one of the deadliest human parasites. Yet, the currently approved vaccine against malaria (RTS,S/AS01) offers limited protection due to challenges in vaccine development. Using current advances made in understanding immunity to address some of the existing challenges, this proposal aims to develop a more efficacious vaccine against P. falciparum by targeting multiple developmental stages (sporozoite, liver and blood-stage). In this project, combinations of 1) highly promising whole parasite vaccination approach targeting the liver (late-arresting GAP), 2) RTS,S (provided by GSK) and 3) mRNA versions of clinically evaluated and partially protective blood stage vaccine candidates (Rh5, AMA1-DiCo [sporozoite and blood stage]) will be evaluated in preclinical and small-scale human trials to discern the optimal combination for further clinical investigations. To inform a rational design of future vaccine candidates, CAPTIVATE will analyse the vaccine-induced immune response to acquire a full understanding of malaria protective immunity and develop an advanced immunology in-silico platform. While immunity to blood stage malaria is relatively well understood, the mechanisms of adaptive protective immunity for pre-erythrocytic malaria vaccine candidates are less well-established. CAPTIVATE addresses this critical knowledge gap by combining state-of-the-art preclinical and clinical (CHMI) in vivo malaria vaccine efficacy models with an innovative in-silico platform comprising TCR/VDJ sequencing and artificial intelligence predictions, to identify such mechanisms. CAPTIVATE assembles a unique combination of European experts in their respective fields (malaria modelling in primates, clinical vaccine testing, in-silico modelling of immune responses, innovative omics approaches) in an integrated interdisciplinary approach aimed at bringing the next generation malaria vaccines to the clinic.

Keywords: malaria,vaccines,mrna,platform development,mathematical modelling,in silico
Controlling Electrodeposition Processes at the Nanoscale with Well-Ordered Nano-Structured Electrolytes (NanoDep)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1722500.0
EU funding (EUR): 1722500.0
Participants: 1
Project status: SIGNED

Even though electrodeposition processes have been used since the nineteenth century, it is remarkably challenging to control their behaviour on the nanoscale. To the naked eye, deposited metal surface appears homogeneous, yet their morphology at the nanoscale is anything but smooth, with ramified metal structures (dendrites) forming on their surface. The utility of electrodeposition for advanced technologies such as NextGen high-energy metal batteries is proportional to our ability to control metal growth at the nanoscale. In theory, this requirement may be accomplished through nanoscale control over ionic processes. Due to lack of appropriate material systems, it appears that examining and validating this hypothesis, much less meeting its requirements, is currently beyond reach. NanoDep envisions a future in which these requirements are met by the development of nano-structured electrolyte systems with well-ordered conductive and nonconductive nanodomains. Our early results suggest that we may be able to completely prevent uncontrolled dendritic formation by designing structured electrolytes that allow nanoscale regulation over local ionic transport processes. The goals of NanoDep are to (1) uncover the behaviour of uncontrolled nanoscale electrodeposition processes within nano-structured electrolytes, (2) prevent them, and (3) apply these newly acquired insights to the construction of a "real-world" system. To accomplish these goals, we will develop a novel in-situ electrochemical platform for investigating the spatiotemporal electrodeposition behaviour in well-ordered nano-structured model electrolytes. The model system insights and guidelines will be translated into "real-world" macroscale batteries using advanced molecular engineering and self-assembly methods. The successful development of well-ordered nano-structured electrolytes represents an important step toward NextGen high-energy metal batteries based on fully regulated electrodeposition processes.

Keywords: electrodeposition,solid state polymer electrolytes,lithium metal batteries,nano structured materials,metal dendrites,block copolymer self assembly,nanofabrication
From Meaning to Perception: How narratives shape visual processing (VisualNarrative)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

Humans constantly generate expectations of what will happen in the future. Such expectations allow us to quickly absorb incoming data. For example, the visual system takes advantage of the world’s relative stability over space and time to anticipate upcoming input. However, most of what we currently know about predictive visual processing comes from studies using arbitrary associations between simple stimuli, such as gratings or abstract objects, which do not reflect the richness of daily life events. It is largely unknown how more complex, meaning-based expectations influence visual processing. To overcome this barrier, the proposed project will use an ecologically valid paradigm, using picture books, and investigate how such more complex, narrative-based expectations shape visual processing. I hypothesise that narratives will elicit strong expectation signals that impact even the earliest levels of sensory processing. To test this hypothesis, I will first quantify narrative-based expectations derived from the picture stories using state-of-the-art computational modelling. Then, I will assess whether these expectations shape the processing in visual cortical regions of adult human volunteers, using neuroimaging. I will inspect whether such signals become anticipatory as viewers become familiar with the narrative – in line with the idea that upon construction of a world model, the brain predicts upcoming stimuli. Moreover, I will also investigate what brain regions shape such learning of narratives. In a separate eye-tracking experiment, I will explore how narratives influence gaze behaviour, providing another assay into how meaning percolates to visual processing. This project will allow me to conduct creative, original and important research, which will propel my scientific career. More broadly, these lines of inquiry will push the envelope of understanding of human perception and learning, bridging from higher-order cognition to low-level visual processing.

Keywords: cognitive neuroscience,vision,predictive coding,learning,functional magnetic resonance imaging,eyetracking,artificial neural networks,naturalistic stimuli
Development of a Sustainable Bio-Organocatalytic Cascade for Stereoselective Amide Synthesis in Pharmaceutical Applications (SuBStrAte)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 217076.16
EU funding (EUR): 217076.16
Participants: 1
Project status: SIGNED

Amide bond formation is fundamental to the synthesis of a wide array of amide-containing drugs. Conventional methods for amide synthesis typically rely on stoichiometric activating agents that are harmful to the environment and less sustainable. Therefore, there is an urgent need for more efficient, selective, and sustainable methods for amide synthesis. This project addresses these challenges by designing a novel bio-organocatalytic cascade reaction for the stereoselective synthesis of amides, including chiral amides, by integrating biocatalytic and organocatalytic strategies. The proposed method exploits the high chemo- and stereoselectivity of ω-transaminases (ω-TAs) for the synthesis of chiral amines from carbonyl compounds, in conjunction with a newly developed direct amidation method using choline chloride (ChCl) as a green catalyst. This project will thus deliver an innovative platform for the direct transformation of carbonyl compounds into amides in a one-pot process. Adhering to green chemistry principles, the method eliminates the need for hazardous reagents and solvents, while employing mild reaction conditions and renewable catalytic systems. Additionally, microwave-assisted heating is utilized to accelerate the reaction rate, enhance yields, and reduce energy consumption. The bio-organocatalytic cascade will significantly reduce the number of steps, reaction time, and resource consumption compared to traditional methods. It will also be scaled up to demonstrate potential for industrial applications. In summary, this interdisciplinary project combines expertise in biocatalysis, organocatalysis, microwave-assisted synthesis, and analytical chemistry to deliver a viable solution for sustainable amide synthesis, which is critical in pharmaceutical manufacturing.

Keywords: enzymatic cascades,chemo biocatalytic cascades,organocatalysis,biotransformations,asymmetric synthesis
Degradation of micro(nano)plastics in water via Fenton-based Advanced Oxidation Processes under intensified conditions (PlasticOX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-15
End date: 2023-10-14
Duration (months): 13.0
Total project cost (EUR): 82656.48
EU funding (EUR): 82656.48
Participants: 1
Project status: CLOSED

Plastic debris, including micro and nano-sized particles, is considered a top environmental problem that might affect human ability to preserve biodiversity and the availability of safe water supplies in the future. Hence, there is a clear and urgent need for the development of targeted treatment processes for the effective removal of micro(nano)plastics (MNPs) from water. Although advanced oxidation processes (AOPs) have been widely studied for the treatment of different emerging and recalcitrant water pollutants, their application for MNPs removal have been scarcely addressed. Among them, Fenton-based AOPs display significant implementation advantages, which will be explored and optimized in the present project. The main challenge consists in mineralizing pollutants that do not dissolve in water and were designed to be hardly degradable. To face this problem, PlasticOX pursues the development and intensification of advanced treatment strategies, such as homogeneous Fenton and photo-Fenton processes, to age and mineralize MNPs in water. This project seeks to tackle many of the knowledge gaps in the research field of this hot topic. The MNPs degradation will be assessed in terms of fragmentation, polymer deterioration, process efficiency, intermediates identity and kinetic models based on particles with decreasing diameters. Moreover, the effect of particle size, shape and composition will be explored in depth. My unique research background, which includes material science, catalysis, reactor engineering and a preliminary training in polymer science, will allow me to perform this ambitious project. Moreover, I will collaborate and learn from my Supervisors, who have a vast experience in the field. The Marie Curie fellowship will enhance the potential of my future career perspectives empowering me to take leading positions in the field of Wastewater Management worldwide. Moreover, I expect to develop a lasting scientific cooperation with the European host group.

Keywords: microplastics,nanoplastics,advanced oxidation processes,homogeneous catalysis,fenton,photo fenton,water treatment
New Catalysts for Synthesis of Stereodefined and Modifiable Tetrasubstituted Alkenes (HISUBMET)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1651750.0
EU funding (EUR): 1651250.0
Participants: 2
Project status: SIGNED

Tetrasubstituted olefins are key to drug discovery, and the ability to such entities is a compelling goal. Pioneering studies have led to a number of noteworthy advances by significant shortcomings remain. For example, it is especially challenging to access tetrasubstituted alkenes that contain four sizeable substituents or a F atom and/or a CF3 unit. Most protocols can only afford one of the possible isomers. Tetrasubstituted alkenes that contain multiple modifiable substituents are particularly attractive, because they can serve as diversification points that lead to a large assortment of desirable compounds. Olefin metathesis offers a strategically distinct, efficient, and stereodivergent route to such entities. Yet, there are only a few reported olefin metathesis reactions that generate a cyclic tetrasubstituted olefin that does not contain two methyl substituents at each carbon (i.e., no stereochemistry). A much smaller number (four cases) are RCM reactions that afford cyclic tetrasubstituted olefins with one modifiable C–Cl bond. All involve a Ru catalyst. However, olefin metathesis reactions that can generate poly-halogenated olefins cannot be effected with a Ru catalyst (rapid decomposition). Only a Mo or a W catalyst must be used, but such complexes do not exist. We will design a new class of pivoting Mo and W catalysts that can be used to promote efficient RCM and cross-metathesis (CM) reactions that generate a wide range of readily modifiable tetrasubstituted olefins. We will accomplish this by designing catalysts wherein the rotation of the imido and aryloxide ligands is synchronized, so that a proper binding pocket is made available. The expected products, which can serve as versatile diversification points, will contain 2-3 easily modifiable units. We will also design an entirely new class of cyclic Mo and W catalysts for CM between easily accessible trisubstituted alkenes and polyhalogenated alkenes. A unique feature of these catalysts is that intra

Keywords: stereoselective synthesis,stereoselective catalysis
Safe food in a world of changing climate: The doctoral training programme to develop novel control, mitigation and risk assessment methods for biotoxins (BIOTOXDoc)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria,Czechia,Portugal,Spain,Netherlands,Italy,United Kingdom,France
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 2475764.23
EU funding (EUR): 2359908.0
Participants: 20
Project status: SIGNED

There is a massive and urgent need to ensure security and safety of the food supply of the growing world population. The ongoing war in Ukraine as well as the energy crisis emphasized this even further. However, agriculture and food industries continue to be vulnerable to problems of contamination with biotoxins produced by plants, algae and particularly by fungi. Global warming and extreme weather events make the occurrence of these toxic metabolites even less predictable. Alarmingly, the EU currently faces a lack of food safety specialists, as recognised by the European Commission. These challenges lay the foundation for BIOTOXDoc – Safe food in a world of changing climate: The doctoral training programme to develop novel control, mitigation and risk assessment methods for biotoxins. The objective of BIOTOXDoc is to train doctoral students (PhDs) in a broad range of skills and complementary competencies - necessary to innovate various scientific fields and approaches, so urgently needed to control and mitigate biotoxins - by taking advantage of a multidisciplinary, multi-sectoral team of world-class experts. The training and research will include development of early warning systems and on‑site testing by portable mass spectrometry. PhDs will develop novel detoxification strategies of biotoxins and will assess the combined toxicity of co‑occurring biotoxins. Moreover, PhDs will develop much-needed rapid as well as confirmatory tests for biotoxins and aim to close major gaps in our current knowledge of biotoxins. The major common link between all PhDs, working on a wide range of biotoxins at different points along the food and feed chain, is the influence of climate change on biotoxin occurrence and the resulting demand of revised strategies to mitigate its impact on the European population.

Keywords: biotoxins,climate change
Computational Study on the Performance of Iron-Polypyridine Catalysts in Artificial Photosynthesis (CO2RedFePP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-07-01
End date: 2028-06-30
Duration (months): 24.0
Total project cost (EUR): 191918.16
EU funding (EUR): 191918.16
Participants: 2
Project status: SIGNED

As contemporary society faces increasingly difficult challenges arising from climate change, devising means for the reduction of anthropogenic greenhouse emissions has become a focal point of research. The reduction of CO2 to profitable products such as CO is a promising means to that end. Unfortunately, the highly inert CO2 makes this endeavour practically impossible without the use of sophisticated catalytic procedures. Iron-polypyridine (FePP) complexes, were found to be promising candidates, triggering a race to find the optimal catalytic system. Computational studies (including by me) have provided essential insights to groups in this race but have so far been solely used to rationalise experimental results. By combining my in-depth knowledge on the computational investigation of transition metal complexes with the Rulíšek group’s expertise in the handling large chemical sampling spaces and the description of solvation effects and the IOCB’s vast computational resources, we propose a proactive computational investigation into the space of potential FePP catalysts. Therein, we will use a robust quantum chemical protocol, tested in the investigation of FePP properties, in combination with a stepwise elimination procedure to evaluate the expectable suitability of a large sampling space of FePP catalysts w.r.t. the reduction of CO2 to CO. We will further use these data to elucidate the relevance of the chemical features of the FePP class for this reduction reaction. We expect that our data will considerably advance the race for the most active, cost-efficient and selective catalyst for the reduction of CO2 and, therefore, accelerate the development of economical applications the significantly reduce human CO2 emissions. Personally, this project will enhance my scientific knowledge as well as my presentation and tutoring skills, thereby boosting my development as an independent researcher.

Keywords: co2 reduction,artificial photosynthesis,climate change