Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
EOSC Track: Implementing the European Open Science monitoring mechanism (EOSC Track)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: EOSC ecosystem
Action type: Coordination and support actions
Partnership: EOSC (co-programmed)
Countries involved: Greece
Call: Implementation of the EOSC monitoring mechanism (HORIZON-INFRA-2023-EOSC-MONIT-IBA, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 600000.0
EU funding (EUR): 600000.0
Participants: 1
Project status: SIGNED

EOSC Track will develop and operate the European Open Science Observatory, a policy intelligence tool that will monitor policies, investments, digital research outputs, skills and infrastructure capacities related to the Open Science and the European Open Science Cloud (EOSC). Its mission is to simplify and streamline monitoring in the European Open Science ecosystem, to bring a common understanding on how to collect and interpret data appropriate for monitoring, as well as to assist policymakers and research executives across Europe in understanding, shaping, and aligning Open Science and related policies and their implementation. Starting from the current EOSC Observatory developed during the EOSC Future project (TRL7), EOSC Track will transform the service into TRL9, making it an open, secure and trusted platform to serve as the go-to place for Open Science monitoring Europe. It will enhance it with features to improve usability, engagement and collaboration: automate data ingestion from trusted sources such as the OpenAIRE Graph, incorporate collaborative editing and validation of data, add interactive navigation and search, visualisations. It will complement with the EOS Resources Registry which will serve as a learning tool by including narratives from experts to demonstrate the internal processes towards the OS implementation in a country, and stories for impact or best practice. EOSC Track will explore the sustainability of the EOS Observatory by fostering a co-design process with the EOSC tripartite partnership and other interested stakeholders. The objective is to align various monitoring initiatives, offer practical assistance in data collection, and generate 360o reports to establish a de-facto hub for all information around monitoring Open Science and EOSC in Europe. Fast forwarding to 2027, EOSC Track will facilitate a dialogue with the EOSC tripartite Governance to develop a roadmap for ensuring long-term sustainability.

Keywords: open science monitor,eosc monitor,open science observatory,open science policy
Developing novel single-cell technologies to model and perturb intra-tumor interactions and signaling – an innovation program for the next generation of immunotherapies (TROJAN-Cell)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Single-cell genomic technologies have transformed many fields of research. We here seek to do just that in synthetic-immunology and immunotherapy. At present, our understanding of the complex crosstalk within the tumor microenvironment (TME) is still piecemeal, as is our ability to effectively engineer the immune system to attack tumor cells in spite of the robust immune-suppression signaling of the tumor. In line, current immunotherapies are effective only in a small subset of tumor types and patients, emphasizing the dire need to better understand immune-suppressive mechanisms within the TME and develop new immunotherapy strategies. What if we could develop technologies that reprogram the immune system to suit our therapeutic needs? In TROJAN-Cell, we will do so by first uncovering fundamental principles of the immune-tumor niche using advanced single-cell multiomics tools and modelling approaches. This will then serve to develop TROJAN-Cell—a novel synthetic immunology technology for engineering circuits capable of sensing inhibitory-immune signals and generating a proportional self-regulated immune-activation response—thus using the tumor’s own pro-cancer signaling to eradicate it. In Obj.1, we will dissect the principles of the inhibitory crosstalk and signaling in the TME of diverse human tumors using our single-cell technologies PIC-seq and INs-seq. In Obj.2, we will screen and develop mice tumor models that recapitulate the human TME, which we will use to define the function of factors/circuits of interest. In Obj.3, we will develop TROJAN-Cell, a novel toolset for transforming tumor inhibitory signals into potent, highly specific anti-tumor immunity. Our research will greatly expand our understanding of the immune-inhibitory crosstalk in the TME and give rise to novel immune engineering approaches and molecules, which may serve as the next generation of cancer immunotherapies.

Keywords: single cell genomics system immunology immunotherapy
artificial Intelligence To enHAnce Civic pArticipation (ITHACA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Ireland,Greece,Belgium,Austria,Romania,Slovakia
Call: Artificial intelligence, big data and democracy (HORIZON-CL2-2022-DEMOCRACY-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2640875.0
EU funding (EUR): 2640875.0
Participants: 11
Project status: SIGNED

ITHACA project aims to better understand the complexities and controversies for applying AI into the field of civic participation and stimulate new and responsible practices of research and innovation that anchor AI technologies design in human rights, values and principles, and moral and ethical reflection.The project vision is to contribute to the maximisation of the possible positive impact of AI on the functioning of democratic institutions and processes by developing and testing of a human centric Artificially Intelligent and Ethics by Design online discussion platform for civic participation in local governance, which incorporates human and social interpretations into the design process to ensure that AI decision-making processes are explainable, transparent and fair. ITHACA will pay particular attention to the needs and voices of citizens from vulnerable groups, with a view to ensuring that human rights impacts stemming from the design, development and ongoing deployment of algorithmic systems are comprehensively monitored, debated and addressed. Through its pilot activities in two different EU countries, ITHACA plans to assess the ability of AI to enhance citizens participation in the local governance while preventing or minimizing possible adverse effects stemming from unregulated use of AI and empowering citizens with knowledge about the AI model involved. ITHACA will also provide scalable tools for the identification of security risks and threats and for conformity with the Fairness principle and Privacy principle in AI-based systems and big data for civic engagement applications. Based on its implementation experiences, the project will define a data governance framework with relevant ethical principles and practices to be implemented in the design, development, deployment process for AI civic engagement platforms as well as policy recommendations on philosophical, legal and ethical values that should be embedded in the development of such platforms.

Keywords: fundamental rights european values philosophical,legal and ethical values data governance,citizen engagement
Eco-friendly smart multifunctional composite coatings for long-lasting corrosion protection of magnesium and its alloys (SMECOCOAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

The world is moving towards sustainable economic growth and green technologies; therefore, the high specific strength, easy recyclability and lightweight of Magnesium (Mg) based materials make them potential options to minimize weight, save energy and reduce environmental issues. However, their poor corrosion resistance in aqueous and atmospheric conditions limits their widespread usage in many industrial applications. Enormous effort has been made to protect Mg and its alloys against degradation and improve their service time. Despite that, the questions related to their durability, longevity, biocompatibility, cost and environmental impacts must be resolved. This scientific work aims to develop durable, multifunctional multilayer composite (MMC) coatings to provide long-term corrosion protection to Mg-based materials. Durability and long-term protection will be achieved by using eco-friendly materials and considering interfacial adhesion strength between substrate/composite within the multilayers and their surrounding environments. MMC coatings will be prepared to protect Mg-based materials against corrosion and give a visual response when the coating is damaged to achieve this scientific goal. MMC coating will consist of a self-assembled organic layer, a polymeric composite containing corrosion inhibitor and sensing agents loaded metal-organic frameworks (MOF) using a stimuli-responsive polymeric gatekeeper in a single layer and a top self-cleaning hydrophobic polymeric layer. They will provide adequate long-term corrosion protection of Mg-based structures by the synergistic effect of self-cleaning, passive barrier layers and on-demand release of active corrosion inhibitors from loaded MOF. Corrosion-sensing agents encapsulated MOF will monitor the onset of corrosion upon physical damage to the coatings for large area systems. MMC coatings will ensure minimum cost and environmental impacts consistent with desired properties and help to substitute PFAS.

Keywords: corrosion,surface modification,coating and films,organic inorganic hybrid materials,intelligent and self assembled materials
Tandem Repeats Associated with Neurogenomic Somatic Instability and Neurodegeneration (TRANSIT-ND)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 1495557.0
EU funding (EUR): 1495557.0
Participants: 1
Project status: SIGNED

Dementia and other neurodegenerative diseases are among the leading causes of disability worldwide and have an immense societal impact due to lack of effective treatments. For developing better preventive and therapeutic strategies, it is essential to clarify their still largely elusive genetic basis and pathophysiology. Emerging insights from the study of rare hereditary repeat expansion disorders caused by elongations of repetitive DNA sequences ("tandem repeats" (TRs)) indicate that TRs could induce instability of neuronal DNA ("neurogenomic somatic instability"), and thereby instigate molecular changes that lead to neuronal degeneration. However, the role of highly prevalent TR variations or their somatic instability in the pathogenesis of common age-associated neurodegenerative diseases is unknown. Here, I aim to assess the role of TRs and their somatic instability in the pathogenesis of neuronal degeneration, the defining hallmark of all neurodegenerative diseases. To this end, I will 1) systematically identify TRs whose size or somatic instability are related to neuronal degeneration in the general population and/or disease severity in repeat expansion disorders, using an innovative approach combining "liquid biopsy" of neuronal tissue, high-throughput ultra-deep long-read DNA sequencing and ultrasensitive biomarkers of neuronal degeneration, 2) delineate the neuroanatomical pathways affected by TR somatic instability through comprehensive neuroimaging analyses, and 3) disentangle the underlying molecular and cellular mechanisms, using an extensive integrative multi-omics approach with experimental validation in neuronal cell lines and post-mortem human brain tissue. The wealth of unique insights from TRANSIT-ND could substantially increase our understanding of the pathogenesis of neuronal degeneration and provide shared targets for the prevention and treatment of a range of different neurodegenerative diseases that afflict millions of people globally.

Keywords: neuroepidemiology,genetic epidemiology,neurodegenerative diseases,tandem repeats,repeat expansion disorders,huntington disease,spinocerebellar ataxia,somatic instability,genetic association study
Bringing 3D cardiac tissues to high throughput for drug discovery screens (3DCardiacHTS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2023-01-01
End date: 2025-11-30
Duration (months): 35.0
Total project cost (EUR): 1457500.0
EU funding (EUR): 1457500.0
Participants: 1
Project status: SIGNED

1. Cardiovascular disease is the number 1 cause of death worldwide. Novel cardiovascular drugs have a high failure rate of 91% in clinical trials. This failure rate is due to lack of proper cardiac models used to find new drugs. Drug discovery studies rely mainly on 2D culture models, which have insufficient predictive value of the human heart. A new in vitro 3D model has been developed by assembling human cardiomyocytes into a three-dimensional strip configuration (3D cardiac strip) that better mimics the native heart tissue. However, this system is not compatible with the high throughput setting needed to perform drug discovery screens. River BioMedics has found a unique solution to miniaturize the human 3D cardiac strips and use them in a high-throughput assay. We combine two innovative technologies: human induced pluripotent stem cell (hiPSC)-cardiac cells and microfluidic systems. The Open-TOP microfluidic technology developed in the group of Prof. v.d. Berg from the University of Twente enables the culturing hundreds of culture chambers automatically and consistently, which is key in high throughput screens. This technology will enable the production and culture of 3D cardiac strips in large numbers, bringing 3D vitro models into a high throughput scale. The end users of this technology are pharma companies performing drug discovery activities and CROs providing drug discovery services. For commercialization of 3DCardiacHTS we plan to partner with an end-user and assess their requirements for the use of such high throughput technology, with the intention of securing their partnership at the end of the project In parallel we will discuss the various partnering options with identified potential Pharma partners and/or CROs the best financial deal structure for partnership on 3DCardiacHTS and consequently validate the best business model to pursue the commercialization of 3DCardiacHTS.

Keywords: heart on a chip,high throughput,microfluidics,3d cardiac tissue,drug discovery
Enriching HDR edits for enhancing efficacy and precision of HSPC gene therapy (ENRICHING-HDR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 299261.83
EU funding (EUR): 209483.28
Participants: 1
Project status: SIGNED

Hematopoietic stem and progenitor cell (HSPC) gene therapy involving viral vectors has shown remarkable promise in treating severe genetic disorders. The advent of gene editing technologies offers new possibilities for broadening the scope of HSPC gene therapy by enabling precise in situ gene correction or targeted transgene integration through homology-directed repair (HDR). However, HDR efficiency in HSPCs remains limited due to their cell cycle dynamics, suboptimal responses to the repair template, and the dominance of error-prone DNA repair pathways such as non-homologous end joining (NHEJ) and microhomology-mediated end joining (MMEJ), which negatively impact the engraftment of HDR-edited cells in vivo. This proposal aims to overcome these challenges by introducing an innovative "purifying selection" strategy. By using CRISPR/Cas9 to target essential genes that are haplo-insufficient in HSPCs, only cells undergoing HDR-mediated insertion of the gene of interest (GOI) will restore the function of the essential gene, while non-HDR edited cells will fail to recover, leading to their elimination. This selective enrichment of HDR-edited cells will dramatically enhance the precision and efficacy of gene editing. ENRICHING-HDR project will focus on identifying critical genes required for HSPC survival and maintenance through genome-wide CRISPR screening, selecting the most promising candidates for purifying selection, and evaluating the system's precision and platformability for clinical application. This project will establish a standardized platform for guide/nuclease reagents and template delivery, enabling reliable genomic integration and rapid adaptation of new therapeutic transgenes, streamlining the development of targeted therapies. The comprehensive training in advanced experimental techniques, research communication, and knowledge transfer will be instrumental in shaping my career trajectory, driving me toward my goal of becoming an independent researcher.

Keywords: gene therapy,gene editing,homology directed repair,hematopoietic stem and progenitor cells,genome integrity
Designing a Novel Protein Inspired Therapeutic Against Xylella (PROTaX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

This project aims to develop an innovative protein therapy to combat Xylella fastidiosa (Xf), a plant pathogen causing significant economic losses in high-value crops such as olive, grapevine, almond, and blueberries. Xf has particularly impacted agriculture in the Mediterranean Basin, with the widespread decline of ancient olive groves in southern Italy serving as a prominent example. Current management strategies are ineffective, underscoring the need for novel disease control solutions - an issue central to the MultiX grant on Xf virulence and plant immunity. Our key inventive step is based on the hypothesis that the phytomicrobiome of a non-host plant contains factors that inhibit Xf. Through experiments and proteomics, we have identified a protein that demonstrates inhibitory activity against Xf. This protein shows significant promise and, with further refinement and optimization, could be developed into an effective therapy. Building on this discovery, PROTaX will design an effective therapeutic and demonstrated its potential to manage Xf infections. Furthermore, we will have gained a deeper understanding of market interests.

Keywords: xylella fastidiosa,microbiome
Deciphering the eccDNA inheritance with novel plant eccDNA genetic tools (circlePLANT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: CLOSED

Enhancing plants’ natural innate and immune systems for the generation of primed plants that will better withstand stressors, can be an effective way to reduce losses in crop production. These systems are broadly defined under the plant transgenerational inheritance (TI) of stress memory, which is based on the heritability of attained traits caused by environmental conditions. I propose a new player in plant TI: the extrachromosomal circular DNA (eccDNA). EccDNA is recognized as a major source of genetic variation behind key adaptive traits. I hypothesize that stress-responsive eccDNAs in the soma of a plant can be considered as adaptive toolkits, that can be transferred to the gametes during meiosis, and thus to the progeny. Thus, I have developed an ambitious but feasible plan, to bridge two major gaps in this context: (1) We require innovative technologies to prove causation, so I will develop the first and novel genetic toolbox to study eccDNAs in plants, by targeted circularization driven by the novel CRISPR-C system; (2) We lack knowledge about how eccDNAs are inherited, so I will characterize the transmission of eccDNAs from the soma to the gametophyte in Arabidopsis, through genome-scale (Circle-seq) and cytological analysis (FISH). CirclePLANT offers a unique opportunity for the development of a new line of research, with potentially remarkable impact because it will explore the bases for eccDNA-based technologies that may be useful in crop breeding, ultimately leading to the generation of stable climate-smart crops, which fits with the environmental objectives of the European Common Agricultural Policy (CAP) of improving crop yields by applying low-input agricultural practices.

Keywords: extrachromosomal circular dna,transgenerational inheritance,meiosis,crispr c,arabidopsis thaliana