Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Participatory science toolkit against pollution (ACTION)

Framework: Horizon 2020 — Science with and for Society
Programme: Integrate society in science and innovation issues, policies and activities in order to integrate citizens' interests and values and to increase the quality, relevance, social acceptability and sustainability of research and innovation outcomes in various fields of activity from social innovation to areas such as biotechnology and nanotechnology
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Italy,Italy,Norway,Norway,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Exploring and supporting citizen science (H2020-SwafS-2018-1, 2018)
Start date: 2019-02-01
End date: 2022-01-31
Duration (months): 36.0
Total project cost (EUR): 1994911.25
EU funding (EUR): 1994911.25
Participants: 11
Project status: CLOSED

ACTION will transform the way we do citizen science (CS) today: from a mostly scientist-led process to a more participatory, inclusive, citizen-led one, which acknowledges the diversity of the CS landscape and of the challenges CS teams have to meet as their project evolves. We have partnered with 5 European CS initiatives tackling major forms of pollution, which pose substantial threats to human health and to the environment, and contributing to Sustainable Development Goals. These pilots will be the starting point for a ‘citizen science accelerator’, which will be expanded through an open call. By considering the needs of multiple stakeholders throughout the lifecycle of CS, we will create methodologies, tools and guidelines to truly democratise the scientific process , allowing anyone to design and realise a CS project from the early stages of ideation to validating and publishing the results. Our research will account for the multitude of manifestations of CS, addressing everything from from small-scale, localised social issues to international research agendas. All ACTION’s outputs - infrastructure, the citizen science platform and toolkit - will be made openly available for online and offline use. They will use accessible formats and interfaces, which appeal to audiences with diverse motivations and backgrounds and provide detailed examples, workflows, and advice tailored for a range of activities, going beyond data collection and analysis. Our digital infrastructure will help citizen scientists use existing specialised platforms and publish results according to RRI principles, including open science. Our toolkit will tackle common difficulties around methodological choices, quality, incentives, community building and sustainability. In addition, the 35 pilots hosted by the accelerator will result in case studies that will demonstrate the impacts of CS at social, economic, environmental and policy level.

Keywords: combating and preventing pollution,sustainable development goals,openness,diversity,sustainability,evolution,citizen science life cycle,citizen science accelerator
Death Receptors as Integrators of Stress-induced inflammation (DESTRESS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Ireland
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2499386.25
EU funding (EUR): 2499386.25
Participants: 1
Project status: SIGNED

Inflammation is initiated in response to the detection of foreign entities, called PAMPs derived from infectious agents, or due to the release of intracellular contents, called DAMPs, due to serious tissue damage (i.e. necrosis). However, inflammation can also be initiated in response to Cell Stress (e.g. ER stress, cytoplasmic stress, mitochondrial stress) resulting from perturbations in normal physiology, but how cellular stress is converted to inflammatory outputs is very poorly understood. Many diseases are associated with chronic long-term inflammation (e.g. cancer, obesity, neurodegeneration, diabetes), which is a compounding factor in these conditions that can accelerate disease progression, but the inflammation seen in these conditions does not have an obvious infectious (PAMP) or acute injury (DAMP) cause. Instead, these diseases are frequently associated with persistent cell/tissue stress (e.g. due to misfolded proteins, elevated dietary fats, or metabolic stress) arising from persistent ER or cytoplasmic stress, that is likely to serve as a key driver of inflammation in these settings. However, the key sensors and effectors of stress-induced inflammation remain enigmatic. Based on our recent observations, I wish to explore the hypothesis that members of the 'Death Receptor' subset of the TNF receptor family serve as stress-associated molecular patterns (SAMPs), becoming upregulated and/or activated in response to divergent forms of ER and cytoplasmic stress, leading to inflammation. Here, we will explore the role of Death Receptors as putative SAMPs, how they are activated by stress, the composition of their stress-induced signaling complexes, and the potential to suppress stress-induced inflammation through targeting these receptors. Understanding how Cell Stress initiates inflammation will open up a new frontier in inflammation research and identify new molecular targets for the treatment of chronic inflammation associated with multiple diseases.

Keywords: inflammation,death receptors,cell stress,er stress,tnf receptor family,trail receptor
Perovskite Light Emitters (PLE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-01-01
End date: 2017-06-30
Duration (months): 18.0
Total project cost (EUR): 149983.0
EU funding (EUR): 149983.0
Participants: 1
Project status: CLOSED

Metal halide perovskites have recently astonished the research community and garnered a mass following to realize extremely high efficiency low cost photovoltaics. This work was largely catalyzed by outputs from the ERC-Stg HYPER, but in addition to solar cell applications, these materials could also be near perfect light emission materials for displays and lighting. This POC grant will formulate a strategy to move the perovskite materials and device research towards commercial exploitation as light sources. Within the project an assessment of the impact perovskite nanocrystals could have in the current lighting market will be undertaken, and a strategy to capitalise upon exiting Oxford IP and how best to develop foreground IP will be formulated. To complement these activities, a demonstrator perovskite light source will be created. From the derived information on IP and business development, a business plan will be delivered which will be taken to the investor community following successful completion of the POC project. This project will therefore enable the transition for perovskite light emitting nanocrystals from University research to a commercial venture.

Keywords: materials science,perovskite materials,demonstrator light source,nanocrystals,commercialization,prototype,business plan,spin out
Mechanoradicals in Collagen (RADICOL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1998873.0
EU funding (EUR): 1998873.0
Participants: 1
Project status: SIGNED

Our tissues, in particular collagen as the most abundant protein in our body, are constantly exposed to mechanical loads, reaching multiples of the body weight. In artificial polymers, mechanical loads are known for a century to cause radical formation and chemical degradation processes. Mechanoradicals from bond ruptures, being highly reactive and oxidising, deteriorate the material, leading to stiffening and ageing. Ageing of organic tissue is a fundamental problem in health and disease, but a role of mechanoradicals has been a blind spot. Our simple but novel idea is to test the role of mechanoradicals for ageing of biomaterials. As a starting point, we have recently uncovered mechanoradicals in tensed tendon collagen. They readily react with water to form reactive oxygen species (ROS), key signalling molecules in a multitude of physiological processes including ageing. I hypothesise that mechanoradicals generate a feedback loop resulting in accelerated collagen ageing. Using a scale-bridging combined computational and experimental approach, I will dissect the full lifecycle of mechanoradicals in collagen, from bond scission and radical migration to ROS formation, to uncover new mechanisms of radical-mediated ageing. We will perform quantum chemical calculations and Molecular Dynamics (MD) simulations, including a new reactive Monte Carlo/MD scheme, to identify scissile bonds and subsequent radical reactions in atomistic collagen I fibril models. For validation, a combination of electron-paramagnetic resonance spectroscopy, mass spectrometry and other biophysical experiments will be employed to measure degradation pathways, radicals and ROS under varying crosslink densities and types as present in young, aged and diseased tendon tissues. RADICOL will establish protein mechanoradicals as an as yet uncovered source of oxidative stress, and as a new paradigm of biological mechanosensation and ageing.

Keywords: computational biophysics,protein biochemistry,material ageing,collagen
Realtime Adaptive Prototyping for Industrial Design of Multimodal Interactive eXpressive technology (RAPID-MIX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Content technologies and information management: ICT for digital content, cultural and creative industries
Action type: Innovation actions
Countries involved: Spain,France,France,United Kingdom,United Kingdom,Portugal
Call: Multimodal and Natural computer interaction (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 2682586.25
EU funding (EUR): 2330004.0
Participants: 9
Project status: CLOSED

RAPID-MIX brings together 3 leading research institutions with 4 dynamic creative industries SMEs and 1 leading wearable technology SME in a technology transfer consortium to bring to market innovative interface products for music, gaming, and e-Health applications. RAPID-MIX uses an intensely user-centric development process to gauge industry pull and end-user desire for new modes of interaction that integrate physiological human sensing, gesture and body language, and smart information analysis and adaptation. Physiological biosignals (EEG, EMG) are used in multimodal hardware configurations with motion sensors and haptic actuators. Advanced machine learning software adapts to expressive human variation, allowing fluid interaction and personalized experience. An iterative, rapid development cycle of hardware prototyping, software development, and application integration accelerates the availability of advanced interface technologies to industry partners. An equally user-centric evaluation phase assures market validation and end-user relevance and usability, feeding back to subsequent design cycles and informing ultimate market deployment. The RAPID-MIX consortium leverages contemporary dissemination channels such as crowd funding, industry trade shows, and contributions to the DIY community to raise awareness across the professional and consumer landscapes of novel interface technologies. Project output is encapsulated in an Open Source RAPID-API exposing application level access to software libraries, hardware designs, and middleware layers. This will enable creative partner SMEs to build a new range of products called Multimodal Interactive eXpressive systems (MIX). It also allows broader industries such as quantified self, and DIY communities, to use the API in their own products in cost effective ways. This assures the legacy of RAPID-MIX and marks its contribution to European competitiveness in rapidly evolving markets for embodied interaction technologies.

Keywords: multimodal interfaces,embodiment,biosensing,user centred design,non verbal communication,expressiveness,music,videogame,wellbeing,wearables,motion,mobile,audiovisual,open acces
The Choice for Europe since Maastricht. Member States' Preferences for Economic and Financial Integration (EMU Choices (former EMU_SCEUS))

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Italy,Austria,Switzerland,Switzerland,Hungary,Sweden,France,France,United Kingdom
Call: Resilient and sustainable economic and monetary union in Europe (H2020-EURO-SOCIETY-2014, 2014)
Start date: 2015-07-01
End date: 2019-06-30
Duration (months): 48.0
Total project cost (EUR): 2290669.0
EU funding (EUR): 2150794.0
Participants: 11
Project status: CLOSED

The Eurozone crisis corroborated the warnings of economists that weak economic policy coordination and loose fiscal oversight would be insufficient to stabilise the monetary union. To prevent a recurrence of the crisis, economists, political actors and the “Blueprint” of the European Commission are asking for the construction of a deep and genuine economic and monetary union with reinforced governance architecture – beyond the recently adopted mechanisms. Many models of a fiscal union have been proposed and discussed. What is missing are not ideas and economic analysis, but the political consensus among member states’ governments for a specific integration path. Therefore, this political science project analyses the politics of economic and fiscal integration, that is, the conflict structure among member states. To this end, we aim to study the preferences of member states’ governments’ for different models of a fiscal union. Our theoretical framework builds on the comparative political economy literature and liberal intergovernmentalism and argues that domestic economic, fiscal and political factors are the main determinants of member states’ preferences. To empirically study the extent to which governments’ preferences are shaped by these factors, we propose to conduct 165 semi-structured interviews with decision makers in all member states. The interview data will be analysed with a mixed-method strategy – including quantitative analysis as well as case studies. We fully expect that the findings of the project will provide guidance for the successful implementation of a feasible reform of the governance architecture of the EU to the effective stabilisation of the economy. In addition to the political feasibility analysis, we aim to study the legal context of potential integration scenarios. The consortium conducting this research covers all regions of the EU and consists of 8 distinguished political scientists and one legal scholar.

Keywords: comparative political economy,public policy,legal analysis,european integration studies
Traveling Wave Tube based W-band Wireless Networks with High Data Rate, Distribution, Spectrum and Energy Efficiency (TWEETHER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,France,France,France,France,France,United Kingdom
Call: Smart optical and wireless network technologies (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2018-09-30
Duration (months): 45.0
Total project cost (EUR): 3333722.5
EU funding (EUR): 3333722.5
Participants: 11
Project status: CLOSED

Never technology has penetrated so deeply and fast in society everyday life as Internet has done in the last decades and is expected to do in the future. The enormous flux of data transferred via wireless networks, increasing at exponential pace, makes today’s state of the art networks soon outdated. Large parts of the society are deprived of adequate access to Internet due to the high costs, long deployment time of optical fibres and inadequate performance of wireless networks. This inequality will most likely pertain in the next years. Millimetre waves are the most promising solution to support the increasing data throughput and to be a credible fibre complement for the last miles. The TWEETHER aim is to realise the millimetre wave Point to multi Point segment to finally link fibre, and sub-6GHz distribution for a full three segment hybrid network, that is the most cost-effective architecture to reach mobile or fixed final individual client. The TWEETHER project responds to the call H2020-ICT6, to foster smart wireless network architecture for high capacity everywhere outdoor data distribution, in gigabit class, that other technologies cannot support, at low operating cost. High spectrum and energy efficient W-band (92-95GHz) technology will be developed. A powerful and compact transmission hub based on a novel traveling wave tube power amplifier with performance precluded to any other technology and an advanced chipset in a compact terminal will be realised. The TWEETHER system will be tested in a real operating environment. Integrated smart networks of backhaul for 4G and 5G small cells and of access for residential houses are the targeted market that benefits from the actual light regulation of W-band. A big company Thales Electron Devices, four SMEs, Bluwan, OMMIC, HFSE, Fibernova, and three top Universities, Lancaster, Goethe Frankfurt, Politecnica de Valencia, join their expertise to successfully tackle the formidable challenges of the TWEETHER project.

Keywords: w band,wireless network,access,backhaul,traveling wave tube,chipset,mmic,transmission hub
Understanding the light-fastness of heritage Turkey Red textiles through modern dye chemistry and historical dyeing technology to inform sustainable display and access (LightFasTR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-03-20
End date: 2019-03-19
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

LightFasTR seeks to increase physical and creative access to Europe’s most profitable globalised textile of the 19th c. Industrial Revolution - Turkey red (TR) printed cotton. TR was famed for colourful bold patterns on a characteristic bright red background. Many 19th c. TR printed cottons survive within the pages of pattern books as well-preserved, vibrant and creative storyboards of forgotten global trade and cultural connections. Museums and archives want to exhibit these collections and increase access, but need to preserve the colours, especially the characteristic red. The 19th c. TR makers’ claim of excellent light-fastness for the red dye is unproven, raising uncertainty about suitable light levels and exposure times for historical TR textile collections. LightFasTR unites the materials and processes of making 19th c. TR with modern dye chemistry and heritage textile conservation science to provide essential guidance for museums and archives. LightFasTR draws upon the Fellow’s expertise in dye chemistry and reaction mechanisms, and extensive research knowledge of industrial dyeing, notably madder, the traditional natural dye for TR. The Fellow takes an innovative approach to heritage TR preservation by combining historical research of different 19th c. materials and methods with state-of–the art chemical studies of the colorants in historical and reconstructed textiles. LightFasTR seeks to answer: to what extent do differences in materials, methods, makers and period impact on TR colour light-fastness? How much light exposure is safe for historical TR, particularly the red dyes? Should recommended current light-levels in museums and archives be increased or decreased for TR? The Fellow brings the host organisation a unique skill-set of natural dye chemistry for industrialised dyeing to create a world-class knowledge base in the lost tacit and technical skills needed to needed to understand and preserve Europe’s surviving TR heritage.

Keywords: conservation,textile design,dye chemistry,natural dye industry revival
Validation of Innovative Lipopeptide Antibiotics (VOILA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Antibiotic resistance presents a growing threat to global health. The emergence of the superbugs is alarming: at current rates of increase, and without new intervention strategies, antibiotic resistance could cause a staggering 10 million deaths/year worldwide by 2050. Therefore, new approaches need to be developed to combat antibiotic resistance, particularly for the WHO’s priority pathogens which include the so-called ESKAPE family of dangerous drug-resistant bacteria. Recently, we developed a novel technology platform comprising a set of methodologies to semisynthetically modify the natural antibiotic nisin. In doing so we generated novel lipopeptide antibiotics with a much higher in vivo stability than the parent compound. These semisynthetic antibiotics possess a lipid II-mediated mode of action similar to nisin, which sets them apart from any current clinically-used antibiotic. During my ERC CoG, we have significantly improved these compounds, i.e. increased their antimicrobial activity and eliminated undesired haemolytic effects. Importantly, preliminary data shows that these antibiotics have a lower propensity to lose their potency due to antibiotic resistance development. I propose that these innovative lipopeptide antibiotics present a significant step forward in addressing the alarming threat of antibiotic resistance. However, to establish their commercial viability and broad applicability, the efficacy and preliminary safety of the new compounds need to be addressed. This can best be achieved via a PK/PD proof of concept study in appropriate animal models along with with a detailed evaluation of the business opportunity. The main objective of VOILA is therefore to establish both the technical feasibility and commercial viability of an entirely new class of lipopeptide antibiotics that is enabled by our innovative technology platform.

Keywords: antibiotics,antibiotic resistance,semi synthesis,mechanism of action,antibacterial assays,pd studies