Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Viral Genome Associated Proteome (VGAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-01
End date: 2019-07-30
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The aim of this study is to analyze the comprehensive proteome associated with viral DNA. This systems biology approach that will combine functional proteomics and genomics has the name Viral Genome Associated Proteome (VGAP). It is based on a modification and refinement of the Hybridization Capture of Chromatin Associated Proteins for Proteomics (HyCCAPP) technology. All proteins associated with viral DNA, initially using Herpes simplex virus for proof of concept, will be cross-linked by paraformaldehyde treatment, the viral DNA will be selectively precipitated, and all proteins associated with the viral genome will be analyzed by mass spectrometry. The results will reveal all cellular and viral proteins that physically interact with the viral genome at a certain time and that are involved among others in regulation of viral genome structure, viral gene expression, DNA repair and cellular intrinsic immunity. The development of VGAP, a new method for the specific analysis of the viral genome-associated proteome will provide a new tool for the research of DNA viruses. In theory VGAP should be applicable to all DNA viruses, and we think it will be possible to analyze proteins associated with the DNA of all DNA viruses, so the entire field of virology should profit from the establishment of viral HyCCAPP. DNA viruses include important human pathogens like herpesviruses, human papillomaviruses and adenoviruses. A plethora of novel viral DNA-protein interactions will be discovered that will spark new research projects and can serve as new targets for antiviral therapy and vaccination strategies. Although beyond the scope of this proposal, so far unknown cellular proteins that are needed for efficient viral replication can be used for screening of small molecule libraries and novel small molecule inhibitors identified for antiviral therapy.

Keywords: herpesviruses,dna damage response,dna binding proteins,innate immunity,restriction factors
Scaling up to the Normandie Hydro Open-Centre Tidal Turbine Pilot Array (OCTARRAY)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Ireland,Poland,France,France,Denmark,United Kingdom
Call: Scaling up in the ocean energy sector to arrays (H2020-LCE-2016-RES-IA, 2016)
Start date: 2017-09-01
End date: 2020-08-31
Duration (months): 36.0
Total project cost (EUR): 117894748.75
EU funding (EUR): 15000000.0
Participants: 6
Project status: CLOSED

OCTARRAY is part of an an ambitious 3-year tidal array demonstration programme located in North Western French territorial waters of the Raz Blanchard, a 15 km strait situated between Cap de la Hague and Alderney Island. The array (known as the Normandie Hydro array) will consist of 7 x 2.0MW Open-Centre Turbines (OCT) designed and constructed by the OpenHydro Group which will be installed at depths of between 30 and 40 meters with a total capacity of 14MW. The turbines will be connected by inter-array cabling via a subsea connector and exported onto the grid via an export cable and substation. The project is scheduled to commence operations and begin exporting grid compliant power to the French National Grid in 2019. The objectives of the project are to develop, construct and operate a tidal turbine array in real conditions and to test and confirm the technical and economic viability of tidal energy in preparation for developments on an industrial and commercial scale. The successful demonstration of the pilot array will achieve several technical, industrial, economic and commercial ‘firsts’ which will facilitate and accelerate the development and growth of the tidal industry. OCTARRAY will establish new knowledge and capability to enable the scale up to future commercial arrays (up to 300MW), Levelised Cost of Energy reduction and will provide valuable data and learning on array effects and performance for the benefit of future tidal array projects in the rest of Europe and strategic locations in the world for renewable energy development. Through projects such as OCTARRAY and the Normandie Hydro array, Europe has the opportunity to significantly build its reputation as a world leader in the development and integration of tidal energy, and benefit from the diversity that the technology brings to the overall energy generation portfolio.

Keywords: hydropower,tidal energy,array
Improved production of low cost silver nanowires (PRISTINE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In the development of new smart phones and tablets, there is a market requirement for alternatives to transparent conductive films (TCF) based on indium tin oxide (ITO). For ITO, the combination of conductive and optical properties is not good enough for many new products, and additionally ITO is brittle and can crack when repeatedly flexed in a touch panel. The leading contender for replacing ITO in TCF is silver nanowires and NANOGAP is the leading European manufacturer of nanowires. With a unique patented technology and resultant freedom to operate, NANOGAP has an excellent competive position in a growing market Based on NANOGAP’s technology and freedom to operate NANOGAP has commercial contracts in place with two global companies. In order grow the customer base and sustain this business opportunity NANOGAP must further enhance its technology, improving product performance to levels demanded by the industry (lower sheet resistance, higher light transmission, lower haze) while lowering costs. This project addresses these requirements by using new methods to both study and optimise the synthesis reaction and through developing new improved post-synthesis purification methods. Additionally, during the feasibility phase of this project, a market study will be performed on verifying new market opportunities for the new improved low cost products arising from this project. The key technical innovations will be around real time monitoring of very sensitive reaction conditions coupled to real time kinetic modelling. It is envisaged that this technique will form the basis of future in-line quality control procedures. Also, very importantly, new cross flow filtration techniques will be assessed for post-synthesis purification with particular interest in bespoke membrane development. The expected results from the technical innovation will be thinner longer nanowires, produced at higher purity and lower cost. This will translate to meeting the customer demands

Keywords: silver nanowires,low cost,real time kinetic modelling,purification,cross flow filtration,low haze,touch panels,oleds,conductive adhesive,emi shielding,smart packaging
Using Network Science to Study Children’s Conceptual Development (ConceptNet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Concepts are mental representations that organize experience. They are the building blocks of ideas (e.g., the thought “birds are animals” requires the knowledge of both the concepts “birds” and the concept “animal”). They enable inductive reasoning and predictive inferences which guide behavior and explanation. Some concepts are already present in infancy. These early concepts are richer than previously thought. However, much of the abstract and sophisticated concepts that make human cognition so special (e.g., scientific concepts) are not present at birth. Thus one of the most exciting challenges in psychology is to understand how abstract concepts develop. Much of the abstract concepts that form the basis of our ability to organize the world and make inferences (e.g. “animal”, “artefact”, “alive beings”) have non-observable shared properties (e.g., a cat and a flower are perceptually quite different, but both belong to the concept alive beings). Thus, the refinement of abstract concepts requires access to cultural cues, mostly via language, which provide information beyond what can be obtained through the senses.,, The goal of this project is to explore how children’s conceptual development can benefit form the language they hear around them. To capture the complexity of the linguistic input as well as the children developing conceptual knowledge, I use methods from the growing field of dynamic networks. I will carry out my research at the Institute of Complex Systems, Paris Île-de-France (ISC-PIF). I will also use the model to provide insights about how scientific concepts can be taught efficiently at school. To this end, I will collaborate with experts in science education at the secondment foundation La Main à La pâte (LAMAP), which is the leading French NGO in developing and promoting best practices in science education.

Keywords: conceptual development,conceptual change,network science
Monitoring cancer heterogeneity based on the dynamic assessment of the Warburg effect under metabolic perturbation (CHyMERA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-02
End date: 2021-05-01
Duration (months): 24.0
Total project cost (EUR): 159815.04
EU funding (EUR): 159815.04
Participants: 1
Project status: CLOSED

Cancer heterogeneity is reflected in the multitude of phenotypes found in the clinic, with different proliferation statuses and metastatic potentials. These features cannot be assessed with the molecular imaging methods commonly available for diagnosis and monitoring. The main goal of this proposal is to develop a molecular imaging methodology based on endogenous contrast – CHyMERA – and demonstrate its feasibility to image hotspot areas of active proliferation and metastatic potential. The approach is based on the concept of cancer metabolic plasticity, does not require contrast agents or radioactive tracers, and should ultimately provide more specificity to cancer diagnosis and treatment planning than other imaging methods currently available. We propose to use animal models of human cancer, a glucose-enhanced imaging method, and an objective analysis of regional metabolic responses to controlled, reversible changes in the tumour microenvironment (perturbations), such as transient hypoxia. Specifically, we will (i) develop and validate CHyMERA at ultra-high magnetic fields, to monitor the metabolic kinetics of glucose and lactate in the tumour microenvironment. This methodology will be (ii) applied in vivo to two immunocompetent mouse model of GBM (allograft and genetically engineered models), to image vascular permeability/perfusion and hotspots of glioma proliferation. Finally, we will (iii) carry out a pilot study with two isogenic mouse models breast of cancer, metastatic and non-metastatic, to generate hotspots maps of proliferation and metastatic potential. All in vivo results will be validated post-mortem by immunohistochemistry. If successful, this methodology has a strong potential for clinical translational, which the host institution is ideally suited to test.
3D Organization of Functionally Conserved Cis-Regulatory Elements (3Dcis)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Embryonic development requires precise spatio-temporal gene expression generating numerous cell types that build the animal body plan. Cell-fate specification and patterning are driven by developmental genes that are often expressed in complex and conserved fashion. Gene expression is precisely modulated by gene regulatory networks (GRNs) constructed through the integration of signalling pathways acting at cis-regulatory elements (CREs). While signalling pathways and GRNs are evolutionary constrained, CREs are poorly conserved at the sequence level, posing the question which cis-regulatory mechanisms facilitate coordinated and conserved gene expression patterns during animal development and evolution. CREs and their target genes are spatially restricted into conserved 3D chromatin structures suggesting a possible link between the less conserved CREs and highly conserved gene expression patterns. In this proposal, I aim to identify CREs that differentially respond to signalling cascades. Novel approaches, such as HiChIP and capture Hi-C, will be applied to decipher the chromatin structure of the associated CREs and their target genes. The application of this approach in two distantly related vertebrate model organisms will allow me to gain insight into genome-wide evolutionary conserved nodes of GRNs controlled by these pathways. Furthermore, detailed analysis of chromatin structures induced by activation or inhibition of signaling cascades will further contribute to understanding of co-dependency and complementarity of genome architecture, cis-regulatory information, and signalling pathways. 3Dcis research will shed light on the mechanisms driving conserved gene expression patterns and common body structures, but also the constraints that different animal lineages have faced during their evolutionary path. Finally, the results will make ground breaking advances in our understanding of how cis-regulatory information and structure of our genome translate into function

Keywords: evodevo,regulatoy landscapes,vertebrate evolution,genome architecture,cis regulatory elements
LIGHT-PROMOTED, IRON-CATALYSED FORMAL HYDROGENATION OF ORGANIC COMPOUNDS (LIONCAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-12-06
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The present proposal aims at the development of new methods for the reduction of alkenes and alkynes combining bioinspired Fe catalysts, photocatalysts and visible light as a source of energy. Organic synthesis is central for a wide range of scientific areas and technologies which rely on accessing molecules of interest in a practical manner, in terms of resources and time frame. Organic synthesis has experienced an enormous development in the last half century, however, the efficient use of resources remains a very significant challenge. Two of the factors influencing this are (i) the extensive use of scarce precious metal catalysts and (ii) the need for high energy reactants to ensure favourable thermodynamics in synthetic processes. In recent years, extensive efforts have been dedicated to the development of technologies for the splitting of water into its components, hydrogen and oxygen. This reaction is thermodynamically disfavoured, requiring an external energy input which can be achieved by the use of a photocatalyst (a compound capable of harvesting energy from light and use it to promote a chemical reaction). These technologies are useful for the production of hydrogen, which is a valuable energy vector and a powerful reductant. On the down side, hydrogen is a very flammable gas with wide explosion limits, which poses serious safety challenges to its storage and use. We propose to investigate the combination of water-splitting technologies with iron-catalysed reduction of organic compounds. In this way, the energy from light is directly used for the reduction of organic compounds and intermediate production of hydrogen is avoided (challenge ii). Moreover, iron is the most abundant element in Earth, so its use is beneficial in terms of sustainability (challenge i). Thus, the proposed research will result in the development of more sustainable methodologies for organic synthesis, streamlining the process and reducing the use of non-renewable feedstocks.

Keywords: iron catalysis,base metal catalysis
ENROUTE: WORK YOUR RIDE (ENROUTE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-10-01
End date: 2019-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Enroute Ltd. is a privately held company founded in Israel with the vision of providing passengers with the best experience in their newly created enroute time. After successfully piloting the prototype version of Enroute technology, the team will be able to confirm the capability of its breakthrough product to open new markets in Europe with the potential for rapid growth. By pursuing the present feasibility study, Enroute’s management team aims to improve its understanding of international market conditions and the associated risks that need to be considered as the company develops a deeper business plan for rolling-out, and scaling up Enroute as a marketable innovative solution. SME Instrument Phase-1 and Phase-2 will be extremely beneficial in helping the company to accelerate development and market penetration of the Enroute solution in target segments, boosting the company’s growth to 45 employees and €84,6M revenues by 2025.

Keywords: travel,time,new business model,mobility software
The choral life in the cities of Bern and Fribourg in the long nineteenth century (CLEFNI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2023-06-03
Duration (months): 36.0
Total project cost (EUR): 304724.16
EU funding (EUR): 304724.16
Participants: 1
Project status: SIGNED

During the 19th century, several music and choral societies arose in Europe, giving rise to a choral movement that fostered not only communal singing, but also patriotic feelings. In Switzerland, this movement involved several men’s choirs that had a strong liberal and patriotic character. This patriotism, however, could not be based on cultural, linguistic or ethnic unity, but called for the integration of the four cultures that make up Switzerland. With its songs and festivals, the Swiss choral movement became a crucial element in this integration process. Yet despite its significance, this movement remains largely ignored by recent scholarship. There is a lack of research on the movement as a whole and principally of specific knowledge about the choral life in different places. The cities of Bern and Fribourg for example have different languages, religions and traditions. To what extent did their choral life differ from or resemble one another? By answering this question, CLEFNI aims to understand how choral activities influenced the social and political life in these cities and contributed to the integration of the Swiss peoples. The objective is to better understand the historical circumstances and the specific conditions that allowed integration and multicultural understanding. CLEFNI is designed as an archival research and will critically analyse sources in archives of 19th-century choral societies in terms of their musical, social and political contexts and of their gender dimensions. Findings will then be discussed in view of existing research on the 19th-century choral movement, on musicology and on related disciplines like sociology and history. Considering that multicultural understanding continues to be a challenge in Europe, CLEFNI’s value goes beyond the Swiss borders, providing new knowledge that contributes to understanding how cultural movements like choral singing may lead to multicultural understanding and integration of cultural minorities.

Keywords: 19th century choral movement,switzerland