Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Combining Artificial Intelligence and smart sensing TOward better management and improved quality of LIFE in chronic obstructive pulmonary disease (TOLIFE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Italy,Belgium,Spain,Germany,Sweden,Greece
Call: Clinical validation of artificial intelligence (AI) solutions for treatment and care (HORIZON-HLTH-2021-DISEASE-04, 2021)
Start date: 2022-09-01
End date: 2027-02-28
Duration (months): 54.0
Total project cost (EUR): 6368235.0
EU funding (EUR): 6368234.0
Participants: 15
Project status: SIGNED

Chronic obstructive pulmonary disease (COPD) is a highly prevalent chronic condition. While COPD is a lung disease, it is mainly the exacerbations and extrapulmonary comorbidities which affect the quality of life, health care costs, and prognosis. The optimal COPD treatment needs to focus on both the characteristics and consequences of the lung disease itself and the diagnosis and treatment of comorbidities. While the severity of lung function impairment is routinely assessed, the exacerbations, the associated comorbidities and limitations in daily life are still significantly underestimated. A personalized approach to COPD management is needed to specifically address the disease, prevent exacerbations, and mitigate its comorbidities to obtain a positive impact on patient health and quality of life. TOLIFE will clinically validate an artificial intelligence (AI) solution to process daily life patient data captured by unobtrusive sensors to enable optimised personalised treatment, assessment of health outcomes and improved quality of life in COPD patients. The TOLIFE approach to COPD management, targeted to predict and mitigate exacerbations and continuously assess the health outcomes, has the potential to reduce mortality, improve health related quality of life and reduce the healthcare costs. TOLIFE will develop and clinically validate an AI-based platform for the early prediction of exacerbations and assessment of the health outcomes. Prediction of exacerbations and assessment of health outcomes will be exploited by clinicians through a patient management tool to perform early and personalized treatment. TOLIFE platform will inform through a disease information tool the patient and caregivers about the patient's health status, the specific treatment plan and lifestyle indications. Two clinical studies will be implemented, one to collect data for AI-tools development and the other to validate the effectiveness of TOLIFE to reduce the risk of exacerbations.

Keywords: copd monitoring and management prediction of copd exacerbations trustworthy artificial intelligence for health smart sensors health technology assessment
Robotic and Electrical Stimulation Platform for Integral Neuromuscular Enhancement (RE-SPINE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-07-01
End date: 2026-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

RE-SPINE develops a real-time neuro-robotic platform for lower limb rehabilitation. Motor recovery following neuromuscular injuries is often sub-optimal. A key barrier hampering progress is that current neurorehabilitation robots interact with the human with limited knowledge of their effect on critical neuromuscular targets. RE-SPINE addresses this challenge by proposing a platform that integrates a stationary robotic ankle exoskeleton with a non-invasive spinal cord electrical stimulation system. This platform generates electrical and mechanical stimuli non-invasively, which are directed to spinal motor neurons and innervated muscle fibers, with precision not considered before. RE-SPINE combines non-invasive biosignal recording and numerical modelling to decode the cellular activity of spinal motor neurons, with the resulting mechanical forces generated by innervated muscle fibers. In this way, residual spinal motor neuron activity is translated into biomechanical force, which is subsequently used to enable volitional and continuous control of a stationary robotic ankle exoskeleton across a wide range of joint rotations, which could not be otherwise achieved without neuro-robotic support. Concurrently, decoded spinal motor neuron activity is used to command spinal cord electrical stimulation patterns that modulate spinal excitability and neuronal synchronization, ultimately for enhancing volitional control of the own leg. Over time, the integrated effects of neuro-controlled electrical and mechanical stimulation promote positive neuro-plastic changes, which are required for gaining an integral motor recovery after injury, with potentials for disrupting current robotic systems for rehabilitation.
The doctoral rift science network for the energy transition (TALENTS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,United Kingdom,France,Iceland,Norway,Greece,Netherlands,Spain,Ethiopia,Italy,Switzerland,United States
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 2700252.0
EU funding (EUR): 2700252.0
Participants: 33
Project status: SIGNED

TALENTS is a European based research network aiming to train early career researchers with the interdisciplinary, science-driven understanding and skills that are the foundation to develop new sustainable solutions for the global challenges of the energy transition. Our joint research focuses on continental rifts which are key regions for geothermal energy, carbon capture and storage, for new resources such as native hydrogen as well as high-risk human habitats due to geohazards such as earthquakes and volcanic activity. We believe that only if we better understand the natural process chains that shape rifts and passive continental margins by investigating key natural laboratories, characterising rift initiation (East African Rift), rift maturation (Gulf of Corinth in Greece, Central European Rifts), and continental breakup (West Iberian margin), we will obtain key knowledge for a safe and sustainable exploration for new, carbon free energies. TALENTS fuses research and training at 18 beneficiaries and academic partners that are among the world leaders in the study of rift systems and 11 companies that are actively involved in the energy transition. The 12 PhD projects address fundamental scientific aspects of rift system processes, collectively bridging several orders of magnitude of spatial and temporal scales. Each doctoral candidate is linked to (1) an academic partner to complement and broaden their scientific training, (2) to a dedicated industry partner to acquire industry-relevant skills and preview possible non-academic career paths, and (3) to a media contact to actively train in communicating their science to the public. Training by research and interaction will be complemented by various forms of education, spanning a wide range of topics to develop scientific and professional skills, to establish ethical standards and to widen career perspectives.

Keywords: geodynamics,geophysics,geomorphology,continental margins,green energy
Intrinsic Microenvironment-Dependent Potentiation of Antibodies for Cancer Therapy (IMPACT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-03-01
End date: 2026-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The principal goal of this proof-of-concept study is to explore the feasibility of a cofactor-induced oligomerisation of IgG to potentiate the therapeutic efficacy of anti-cancer antibodies targeting the tumour site. Our idea is based on two phenomena: Firstly, in our previous studies on the interaction of heme with therapeutic antibodies we found that the interaction of Trastuzumab with heme results in the formation of well-organized oligomers through Fab-Fab interactions of two IgG molecules. These species were considerably more potent in activating the complement system and inducing killing of cancer cells. Importantly, we were able to transfer the potential for oligomeriszation mediated by heme on two unrelated monoclonal antibodies used in clinical practice, thus providing strong evidence of the feasibility of the engineering effort and the utility of its application for broad range of IgG molecules. Secondly, there is strong evidence in the literature about the ability of tumours (especially malignant) to provoke haemorrhages. Based on these two phenomena, we formulated our working hypothesis that the locally released heme and hemoproteins at tumour sites can be harnessed as trigger of oligomerization of engineered IgG molecules, thus increasing their pro-inflammatory and cytotoxic activities due to aggregation of the Fc portion in close proximity. This will result in higher antibody avidity, more efficient cross-linking of Fc-gamma receptors, better recruitment of complement proteins (C1q) and, hence, a stronger activation of the immune effector cells and the classical pathway of complement system on the surface of cancer cells. Successful accomplishment of this project will have considerable societal impact due to clinical and social significance of cancer.
Dissection of Microglial State Biology in Brain Repair (MicroDissect)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Ireland
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 1684803.0
EU funding (EUR): 1684803.0
Participants: 1
Project status: SIGNED

Microglia, the macrophages of the brain, are critical regulators of many neurobiological functions and implicated by human genetics in several central nervous system diseases. Recent studies have revealed that microglia can adopt distinct co-existing subtypes, termed 'states'. Microglial states appear especially in the context of damage, disease or repair and understanding these states may lead to the ability to precisely modulate neuroinflammation. However, due to a lack of datasets and tools, the dynamics and functions of these microglial states are unknown, representing a poorly explored frontier of neuroscience. The core goal of this proposal is to understand the kinetics and biological roles of microglial states. Using focal brain repair in the mouse as a model system, I will address this knowledge gap with three synergistic objectives. First, how do microglial states change in space and time? To answer this, I will unravel the dynamics of microglial states by generating a spatiotemporal atlas of gene expression at the single-cell level, from injury to full repair. Second, how do specific microglial states emerge and what are their functions? I will address this question by focusing on one state that interacts with the peripheral immune system and appears to be triggered by a particular cytokine. Finally, I will build novel molecular tools to genetically access and specifically arrest any microglial state. This will enable me to investigate their impact on remyelination and uncover the biological mechanisms by which microglial states orchestrate brain repair. Together, this work will comprehensively dissect the biology of microglial states in brain repair and provide the enabling technologies to do the same in other contexts, from development to disease. It will open up microglial states to experimentation, resulting in a step change in our understanding of this important brain cell type.
Innovating Secure and Efficient Border Management Through Vehicle-Integrated Technologies (AutoBorder)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Border Management
Action type: Research and Innovation actions
Countries involved: Greece,United Kingdom,Austria,Ireland,Poland,Türkiye,France,Netherlands,Slovakia,Moldova, Republic of,Romania
Call: Open Topic (HORIZON-CL3-2024-BM-01, 2024)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 3529431.79
EU funding (EUR): 2999905.0
Participants: 15
Project status: SIGNED

AutoBorder focuses on developing and implementing innovative solutions for border checks specifically designed for vehicles. The approach leverages cutting-edge technologies, including advanced biometrics and in-car sensors integrated with the car's Infotainment and Control Electronics (ICE) system, to streamline the border-crossing process. By utilizing Digital Travel Credentials (DTCs) and pre-registration systems, the project aims to enhance security while significantly reducing waiting times at land borders. Beyond border checks, the technology enhances passenger security through identity monitoring, real-time alerts for unauthorized access, and predictive analytics for threat detection. This dual-purpose approach improves identity verification and passenger safety during travel, advancing security and connectivity across Europe. Leading actors in several relevant fields actively participate in the project, including biometrics and security experts, car manufacturers and researchers. The project builds on prior EU initiatives (e.g., SMILE, D4FLY, EINSTEIN) and, as a RIA project, targets a Technology Readiness Level (TRL) of 5–6 for most components, with some at TRL4. Validation and demonstration will occur in relevant environments, not connected to actual border systems. Solutions must comply with GDPR, the AI Act, EU travel regulations, and other legal and ethical standards. A dedicated legal/ethical partner will ensure compliance, while social aspects like acceptance and human rights will be addressed. End-user involvement is critical, providing feedback to align solutions with practical needs and enabling pilot demonstrations and validations. AutoBorder involves several EU and non-EU end-users, and has foreseen pilot studies at 2 external EU BCPs (UK-France and Moldova - Romania)

Keywords: land borders,vehicle,biometrics,dtc,in car,non stop
New business for farmers and cooperatives in rural areas by local upcycling solutions using underutilized agricultural feedstocks (PRIMARY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Innovation actions
Countries involved: Finland,Estonia,Greece
Call: From silos to diversity – small-scale bio-based demonstration pilots (HORIZON-CL6-2024-CIRCBIO-02, 2024)
Start date: 2025-05-01
End date: 2029-04-30
Duration (months): 48.0
Total project cost (EUR): 5256210.5
EU funding (EUR): 4996935.5
Participants: 12
Project status: SIGNED

PRIMARY aims to develop and pilot local solutions for the production of food, feed, bio-based materials, bioenergy, and fertilizers by valorizing agricultural biomass feedstocks, including grass, greenhouse and cotton by-products, and olive tree pruning that are currently underutilized and exist in substantial amounts in Europe. The project focuses on North-East Europe (Finland) and South-East Europe (Greece), providing business models and demonstrations in rural areas where pilot and demo plants are rare. PRIMARY works with primary producers and local actors, and pilots six process concepts: 1) separation of protein and fibre rich fractions from grass to produce food/feed and biobased materials, respectively; 2) submerged and 3) solid-state fermentation processes to upcycle the feedstocks to protein rich food and feed ingredients; 4) fibre forming technology to enable production of packaging and construction materials; 5) pelletizing process to solid biofuel for gasification to bioenergy from olive-tree pruning and cotton byproducts; 6) pyrolysis of cotton and olive byproducts to biochar for fertilizer and material applications. The solutions piloted in the project are selected based on cascading use of the feedstocks to find the highest possible value, considering the regional conditions. Sustainability of the new value chains is broadly assessed. To maximise project outcomes and impact, other partners and regions are engaged through an open innovation call to promote the ecosystem for valorizing agricultural biomass, and to show replicability of the project solutions. PRIMARY outcomes, including new processes, products and service concepts, will be communicated via various channels, including a stakeholder platform, to ensure wide exploitation of the solutions. A multi-actor approach is used in the development of processes and replicable business models, and for delivering guidance to farmers and SMEs, and advice to policymakers at national and EU level.

Keywords: agricultural feedstock,biorefinery,grass,greenhouse,olive,cotton,fermentation,extraction,food,feed,fibre forming,biobased materials,bioenergy,biochar,fertilizers,business models,lca
Highly efficient, heavy metal-free color conversion ink technology for microLED applications (QustomDot)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Belgium
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 3571277.5
EU funding (EUR): 2499894.25
Participants: 1
Project status: SIGNED

QustomDot is the first and only company developing an all-around heavy metal-free quantum dot (QD) solution which is fully RoHS-compliant while combining high stability under high light flux with the excellent optical properties required by the microLED applications. This is an urgent demand from the display industry, which cannot develop marketable microLED displays without using an efficient QD color conversion technology (QDCC) free of heavy metals. Our main target customers are the microLED developers/manufacturers, while the users are panel makers, OEMs and the end user. We are already collaborating with key players from all the layers of the value chain, and we have 6 patent families (3 of them already granted). Our unique capacity as key enablers of the microLED technology, will position us as the reference on QDCC for the next-generation display technology. Our vision is to become a world leader in the QD quantum dot market, addressing a 20% of the market share by 2030.

Keywords: chemistry,quantum dots,semiconductors,materials science,thermodynamics
Nanomechanical Hardware Platforms for Edge Computing (i-EDGE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Germany,Sweden,Austria,France,Switzerland,United Kingdom
Call: Innovative materials for advanced (nano)electronic components and systems (RIA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2132745.0
EU funding (EUR): 2132745.0
Participants: 8
Project status: SIGNED

Challenging operating environments are common across many important internet of things (IoT) applications related to enterprises and the circular economy, including automotive, aerospace, industrial and power generation. However, conventional electronics are not suitable for operation in challenging and harsh environments, e.g. at high temperatures. i-EDGE establishes an enabling nanoelectromechanical (NEM) switch technology platform for IoT edge devices operating under demanding conditions, i.e., high temperature (<300 °C) and/or high-radiation (<1 Mrad), uses zero standby power, non-volatile memory and has low compute performance requirements. i-EDGE will realize a proof-of-concept demonstrator of a NEM “system-on-chip” (SoC) IoT node with an FPGA, non-volatile memory, and a temperature sensor, powered by a high-temperature capacitor bank, with a wireless power receiver for trickle charging the capacitor, and a simple data transceiver and sensor readout to interface to the on-chip FPGA and non-volatile memory. The FPGA fabric will be based on the NEM switch technology for digital logic, and integrated with a non-volatile memory array, analog utility blocks for wireless power transfer, data exchange and sensor readout. We will develop a NEM physical design kit (PDK) for design and circuit simulation, which will facilitate broad usage by application engineers. The technology and design flow will be demonstrated with a condition monitoring application, that has been developed for industrial IoT processes. In several previous EU and national projects, our technology has matured to TRL3 and i-EDGE will bring it to TRL5. The i-EDGE consortium has all expertise to establish a full supply chain, from basic logic and memory cell design to Systems-on-Chip and a migration path to pilot manufacturing of the NEM technology in Europe. Thus, i-EDGE will help position the EU at the cutting edge of chip design and manufacturing capabilities, as envisaged by the EU Chips Act.

Keywords: nanoelectromechanical switch nem non volatile memory fpga cmos system integration soc sip iiot harsh environment radiation hardened electronics pdk system level modelling lab to fab