Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Non-archimedean Mirror Symmetry (NAMirror)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1481550.0
EU funding (EUR): 1481550.0
Participants: 1
Project status: CLOSED

Mirror symmetry is one of the most mysterious dualities in mathematics. Roughly, it predicts that given any Calabi-Yau variety, there exists a mirror Calabi-Yau variety such that a rich list of geometric relations hold between the two, involving Hodge numbers, Gromov-Witten invariants, variation of Hodge structures, Floer homology (Fukaya category), coherent sheaves, stability conditions and so on. Despite continual progress in the subject, a fundamental question remains unclear: to what extent do mirrors exist, and how to construct the mirror variety? Here we propose a new approach to answer this question, based on latest developments from non-archimedean geometry, in particular the theory of Berkovich spaces, as well as derived non-archimedean geometry. Our goal is to conceive and pursue a full-fledged theory of non-archimedean mirror symmetry, which will lead to new results unattainable from existing methods. We propose to work out a general mirror construction, starting directly from a non-archimedean Strominger-Yau-Zaslow torus fibration, conjectured by Kontsevich-Soibelman, by counting non-archimedean analytic disks with boundaries on SYZ torus fibers. First we need to establish the existence of such counts in full generality, based on non-archimedean Gromov-Witten theory and tail conditions. Then we have to prove various properties of the mirror algebra, including associativity, radius of convergence and singularity estimates. Finally we propose to use wall-crossing formulas to glue local mirror algebras together to obtain the global mirror variety. A long-term goal is to show that the mirror construction is an involution, the best exhibition of mirror duality. We also aim for applications outside mirror symmetry, in particular towards the moduli of KSBA stable pairs in birational geometry. Our project is intimately related to the ongoing Gross-Siebert program based on logarithmic geometry. We also expect fruitful future interactions with their program.

Keywords: mirror symmetry,non archimedean geometry,berkovich spaces,calabi yau varieties
Deciphering the transport mechanisms of small xenobiotic molecules in synthetic yeast cell factories (YEAST-TRANS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-12-01
End date: 2022-11-30
Duration (months): 60.0
Total project cost (EUR): 1423357.5
EU funding (EUR): 1423357.5
Participants: 1
Project status: CLOSED

Industrial biotechnology employs synthetic cell factories to create bulk and fine chemicals and fuels from renewable resources, laying the basis for the future bio-based economy. The major part of the wanted bio-based chemicals are not native to the host cell, such as yeast, i.e. they are xenobiotic. Some xenobiotic compounds are readily secreted by synthetic cells, some are poorly secreted and some are not secreted at all, but how does this transport occur? Or why does it not occur? These fundamental questions remain to be answered and this will have great implications on industrial biotechnology, because improved secretion would bring down the production costs and enable the emergence of novel bio-based products. YEAST-TRANS will fill in this knowledge gap by carrying out the first systematic genome-scale transporter study to uncover the transport mechanisms of small xenobiotic molecules by synthetic yeast cells and to apply this knowledge for engineering more efficient cell factories for bio-based production of fuels and chemicals.

Keywords: transport proteins,xenopus oocytes expression,saccharomyces cerevisiae transportome,bio based chemicals
Scattering and tapping on soft-hard-open nuts (SCATAPNUT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Austria
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2021-08-31
Duration (months): 60.0
Total project cost (EUR): 1993606.25
EU funding (EUR): 1993606.25
Participants: 1
Project status: CLOSED

Seeds enclosed in maternal tissue are an important evolutionary plant development as they protect the embryo in many different environments. The protecting coverings are very heterogeneous in structure and origin due to different seed dispersal strategies and environments designed for. The ones having hard outer coverings are commonly called nuts and their shells have recently become of interest for biomimetic research as they represent hard and tough lightweight structures with biological and environmental resistance. Biological materials are optimized at numerous length scales. To unravel the design principles on the micro- and nano scale and their assembly are a big challenge in biomimetic research. Thus the objectives of this project are threefold: 1) develop in-situ methods for in-depth characterization at the micro- and nano level, 2) reveal the heterogeneity and common design principles by investigating different species and 3) follow development (soft), maturation (hard) and germination (open). By measuring the inelastic scattering of laser light (RAMAN microscopy), tapping with a tip (Atomic force microscopy AFM, pulsed force mode) and combining both (Scanning near field optical microscopy-SNOM, Tip enhanced Raman spectroscopy-TERS) sophisticated applications for imaging natural packaging structures will be developed. This will enable us to gain new insights into micro- and nanochemistry as well as nanomechanics in the context of tissue and cell organization. Furthermore in-depth knowledge on the developmental processes of cell assembly, maturation and germination will be obtained. This will lead to a better understanding of the underlying design principles, which is important in order to extract structure-function relationships and identify features that contribute e.g. to the high strength and cracking resistance and longevity. Such information is important for biology (agriculture) and will give new input in intelligent biomimetic material design.

Keywords: raman microscopy,scanning probe microscopy,biomimetics,biomechanic
Artificial designer materials (E-DESIGN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Finland
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-09-01
End date: 2024-08-31
Duration (months): 72.0
Total project cost (EUR): 2374922.0
EU funding (EUR): 2374922.0
Participants: 1
Project status: SIGNED

Constructing designer materials where the atomic geometry, interactions, magnetism and other relevant parameters can be precisely controlled is becoming reality. I will reach this aim by positioning every atom with the tip of a scanning probe microscope, or by using molecular self-assembly to reach the desired structures. I will realize and engineer several novel quantum materials hosting exotic electronic phases: 2D topological insulators in metal-organic frameworks (MOF) and 2D topological superconductors in hybrid molecule-superconductor structures. These classes of materials have not yet been experimentally realized but could enable novel spintronic and quantum computing devices. In addition, we will realize a tuneable platform for quantum simulation in solid-state artificial lattices, which could open a whole new area in this field. I will employ a broad experimental approach to reach the above targets by utilizing molecular self-assembly and scanning probe microscopy -based atom/molecule manipulation. The systems are characterized using low-temperature atomic force microscopy (AFM) and scanning tunneling microscopy (STM). My group is one of the leading groups in these topics globally. We have initial results on the topics discussed in this proposal and are thus in a unique position to make ground-breaking contributions in realizing designer quantum materials. The artificial designer materials we study are characterized by the engineered electronic response with atomically precise geometries, lattice symmetries and controlled interactions. Such ingredients can result in ultimately controllable materials that have large, robust and quick responses to small stimuli with applications in nanoelectronics, flexible electronics, high-selectivity and high-sensitivity sensors, and optoelectronic components. Longer term, the biggest impact is expected through a profound change in the way we view materials and what can be achieved through designer materials approach.

Keywords: topological matter,topological insulators,topological superconductors,molecular self assembly,metal organic frameworks mof,atomic force microscopy afm,scanning tunneling microscopy stm
Atlas (Atlas)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-03-01
End date: 2022-02-28
Duration (months): 36.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The human subcortex is a highly crowded brain area, which consists of hundreds of unique, small grey matter nuclei constituting approximately ¼ of total human brain volume. Importantly, only approximately 7% of these nuclei are currently accessible in standard human brain magnetic resonance imaging (MRI) atlases (Forstmann et al., 2016). This low percentage can have several imaging related causes, including the small size of subcortical nuclei as compared to the voxel size, which is particularly relevant when applying 1.5 or 3 Tesla (T) MRI. Additionally, the challenges posed by the large distance of the subcortex from the head coil may be a cause. In light of the vast amount of uncharted brain areas, one can also think of the human subcortex as ‘terra incognita’. The aim of this proposal is to chart ‘terra incognita’ to create a tool to identify and localize new targets for DBS. Major efforts of my group have already been directed towards resolving at least part of the challenges of imaging the human subcortex through the development of ultra-high field resolution 7T magnetic resonance imaging (UHF-MRI) sequences tailored to image the subcortex. Within our project ‘Atlasing the human subcortex’, collaborations with world-leading companies in DBS technology such as Boston Scientific (http://www.vercise.com/index.cfm) have been established. Here, we aim to extend these efforts by applying for funding for research personnel that will execute the manual segmentations and validation of new potentially more efficient target areas for DBS neurosurgery. These efforts will lead to creating probabilistic atlas maps for DBS surgery with unprecedented detail as well as a 3D app for educational purposes both in the clinical and basic neurosciences. These efforts will ultimately lead to commercial products that have already attracted attention of world-leading DBS companies.

Keywords: atlasing,the human subcortex,ultra high field mri
Sustainability Assessment of Harmonised Hydrogen Energy Systems: Guidelines for Life Cycle Sustainability Assessment and Prospective Benchmarking (SH2E)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Coordination and support actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Spain,Germany,Spain,France,France,France,Japan
Call: Guidelines for Life Cycle Sustainability Assessment (LCSA) of fuel cell and hydrogen systems (H2020-JTI-FCH-2020-1, 2020)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 2142778.75
EU funding (EUR): 1997616.25
Participants: 8
Project status: SIGNED

Hydrogen is expected to play a key role as an energy carrier in the path towards global sustainability. Nevertheless, right decisions are needed to make fuel cells and hydrogen (FCH) systems effective in this crusade. Besides technological advancements, methodological solutions that allow checking the suitability of FCH systems under sustainability aspects from a life-cycle perspective are needed to sensibly support decision-making. Such methodological contributions should rely on well-defined guidelines that allow a reliable assessment and benchmarking of FCH systems. In this sense, sound guidelines for Life Cycle Sustainability Assessment (LCSA) of FCH systems are urgently needed. The goal of SH2E is to provide a harmonised (i.e., methodologically consistent) multi-dimensional framework for the LCSA and prospective benchmarking of FCH systems. To that end, SH2E will develop and demonstrate specific guidelines for the environmental (LCA), economic (LCC) and social (SLCA) life cycle assessment and benchmarking of FCH systems, while addressing their consistent integration into robust FCH-LCSA guidelines. These guidelines aim to be globally accepted as the reference document for LCSA of FCH systems and set the basis for future standardisation, going beyond the update of past initiatives such as the FC-HyGuide project and the IEA Hydrogen Task 36 through their reformulation to deal with underdeveloped topics such as material criticality and prospective assessment. For the sake of practicality and extended use of the guidelines, key SH2E outcomes also include user-friendly, open-access software tools with illustrative case studies, also being a source of publicly available data reviewed by a third party. Thus, the project is aligned with international initiatives towards global sustainability, including the Innovation Challenge on Renewable and Clean Hydrogen, by providing robust frameworks and tools that help decision-makers check the sustainability of FCH solutions.

Keywords: sustainability assessment,life cycle assessment,life cycle costing,social impact,hydrogen,fuel cell,harmonisation,prospective assessment,material criticality,benchmarking,guidelines
Training the people. A transnational history of sport in interwar Europe. (Training People)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

This project will explore the changing nature of European sport in the interwar period from a transnational perspective, combining cultural, political and social history. Based on the German, French, Italian and British cases but with reference to other countries, this innovative work will permit the writing of a standard work to fill a major gap in the subject which has been dominated by national histories. The interwar years were a critical period for the development of sport in Europe: the traditional ‘amateur ideal’ gave way to athletes who embodied new national and social causes. The flourishing development of physical culture (German Turnen and games, Swedish/Danish gymnastics, ‘English’ sports…) was marked by the powerful politicising of sport as well as the expansion of the press and broadcast media, which influenced people and governments to an unprecedented degree. The ideal of the ‘New Man’ best exemplified this change. This research will bring to the fore the similarities that have been obscured as well as striking national differences. In taking Europe as a point of departure, this work will focus on three areas. (1) Hygiene: how the post-war body was to be (re)educated: (1.1) national health campaigns and (1.2) new school curricula. (2) The politics of sport: as expressed through (2.1) the nature and extent of institutionalisation and (2.2) the growing importance of ‘mega events’, especially the Olympics and the FIFA World Cup. (3) The increasing specialisation of sport: (3.1) how amateurism came under threat from professionalism and (3.2) how scientific research into physical culture was expanded. The researcher brings all the necessary qualities and maturity to realise this highly ambitious project. She will be hosted in a major German university by a world-leading professor recognised for his scientific excellence and dynamism in the field. The project’s sources are held in various European libraries and institutions already known to the researcher.

Keywords: transnational history,sport,physical culture,europe,interwar period
Direct reprogramming for HD Disease Modelling (DISMOD-HD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-15
End date: 2019-10-12
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

Huntington’s disease (HD) is a rare and devastating autosomal dominantly inherited disorder caused by the amplification of the CAG codon in the huntingtin gene. The clinical symptoms of HD are chorea and motor incoordination as well as psychiatric symptoms. To date no cure has been found to alter the progression of the striatal atrophy due to the dramatic loss of GABAergic medium spiny neurons (MSNs) which eventually leads to death. Over the past years increasing knowledge around the function of huntingtin (HTT) has allowed the identification of number pathogenic mechanisms, however the specific processes whereby the mutated HTT leads to degeneration and their temporal evolution remains unknown. We believe it is of vital importance to develop disease-relevant human cell models from clinically characterized HD subjects in which to address questions related to pathogenic mechanisms and their dependence on the CAG repeats. For this reason the aim of the proposed project is to generate induced medium spiny neurons (iMSNs) from healthy or HD-diseased fibroblasts in order to generate a reliable disease modelling tool. The applicant will optimize an existing protocol for the generation of iMSNs from direct conversion of fibroblasts published by Victor et al (2014) to obtain healthy iMSNs in the laboratory of prof. Elena Cattaneo at the University of Milan. In a second step she will perform direct in vitro reprogramming of human fibroblasts derived from well characterized patients affected with HD exhibiting different degrees of CAG repeat expansion into induced HD-derived MSNs (HD-iMSNs). Finally, the newly generated HD-iMSNs will be analyzed, and their characteristics compared to those of the healthy iMSNs, in order to assess their appropriatness as a disease modelling tool to investigate the pathophysiology and pathogenesis of HD.

Keywords: direct reprogramming,medium spiny neurons,huntington disease,disease modelling
KAM to West Poland 2 (KAM2WP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Poland,Poland,Poland,Poland,Poland,Poland,Poland,Poland
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 85000.0
EU funding (EUR): 85000.0
Participants: 9
Project status: CLOSED

The objective of the project is to contribute to and enhance the innovation potential and innovation management skills within SMEs in the West Poland area. The project will follow a developed methodology to help the regional businesses to increase their innovation capacity and to innovate profitably. The project will be implemented via 2 specific schemes: 1) Service ‘Key account management for SME Instrument beneficiaries’. This service will be aimed at SMEs which will be successful in applying for the SME Instrument Programme under the Horizon 2020 (Phase I and / or Phase II). Upon the receipt of the information (potential beneficiary’s contact details) from the EC/ EASME, the project partner will contact the potential beneficiary in order to explain the service and convince the SME to apply for the coaching scheme. 2) Service: ‘Enhancing the innovation management capacity of SME’s’. This service will be aimed at promising SMEs capable of growth and successful internationalisation that have real potential for innovation via proper development of their products, processes, services or business model but who lack the right skills, knowledge and experience to manage the innovation activities. The aim of this scheme is to first of all support those SMEs in order to make them unlock their potential for better management of the processes linked to innovation.

Keywords: innovation management,capacity building,innovation expert,sme instrument,key account management,horizon 2020,enhancing innovation performance