Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of multi-source micro energy harvesting power management devices (HarvestAll)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-25
End date: 2018-10-24
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Many IoT market leaders incl. ARM Holdings (the world's leading semiconductor IP supplier) predict that the IoT will begin to free itself from battery power in 2018. Without reducing the reliance on battery power, there is a significant roadblock in reaching trillions of devices. Future devices will need to be self-sufficient and operate without any battery swaps or any human intervention for decades. This will be made possible through harvesting of all the available ambient energy in the environment, for example: Thermal energy associated with static and dynamic temperature differences; Vibration energy e.g. from vehicles driving over a bridge or oil following through a pipe; Light energy from indoor artificial lighting. For these predictions to be realised, the current roadblock is micro energy harvesting systems that can effectively capture all available energy using just one energy management device. The technical challenge is that these ambient energy sources have widely different electrical characteristics that must be managed e.g: photovoltaic and thermoelectric harvesters are low-voltage DC, resistive, “trickle” sources; electrodynamic harvesters are high-voltage, inductive, “pulsed” sources whilst piezoelectric harvesters are high-voltage AC, capacitive, “bursty” sources. Trameto is a UK-based fabless semiconductor business that is focusing on bringing ‘HarvestAll’ to market. HarvestAll enables energy harvesting from any-single harvester type, many-identical harvesters and multiple-different harvester types. This functionality is not currently available in the market. This project will help us to: further strengthen our market understanding, formalise existing and build new relationships with partners across the energy harvesting ecosystem to develop our supply chain and routes to market. This project will take us closer to having an exploitable technology that will achieve an ROI of 13.9:1 through sales of our novel energy management chip.

Keywords: internet of things,micro energy harvesting,power management device,multi source harvesting,photovoltaic,electrodynamic,piezoelectric,thermodynamic,fabless,effective operating area
The Westernmost and Easternmost Borders of Christendom: Early Christianity in Armenia and Ireland (CHRISTIAN_FRONTIERS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-16
End date: 2022-11-15
Duration (months): 24.0
Total project cost (EUR): 196590.72
EU funding (EUR): 196590.72
Participants: 1
Project status: CLOSED

The Christian_Frontiers aims to research the early history of Christianity in the westernmost and easternmost borders of Christendom, that is, in Armenia and Ireland. Neither Armenia, nor Ireland were just the confines of the Roman world, but also the Pax Romana. The aim of this project is to trace early Armenian and Irish Christian identity, to determine how they identified themselves regarding the Roman papacy and how Rome perceived these two remote churches, which were beyond empires. During the work on the Christian_Frontiers not only the history of two national churches will be examined, but also the defending features of Eastern and Western Churches will be explored through the example of Irish and Armenian churches. The history of Irish Christianity has never been researched in comparison to Eastern Christianity, just as Armenian Church has never been considered in context with the Western one. Such a fresh approach in combination with the usage of modern methodology and a wide range of sources, as well as the guidance of an experienced Supervisor will enable the Fellow to provide an original and fresh view on the early medieval history of the countries. To achieve the desired results The Fellow will work in different libraries in Ireland and Armenia to have access to a wide range of sources and references. Consultation-meetings with the supervisors from the Host and Secondment, and other professional trainings, including Latin courses will be undertaken. Apart from professional skills, the Fellow will gain and improve a number of transferable skills by undertaking the trainings organized by UCC. Hence the contribution to the Researcher’s knowledge and career development, creation of wide scientific ties, publications in the relevant peer-reviewed will assist the Researcher in achieving professional maturity and increase her employability.

Keywords: ireland,armenia,early christianity,roman papacy,christian identity,eastern christianity,western christianity,universal church
Implementation and preclinical testing of a closed-loop control system for deep brain stimulation (DBScontrol)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Ireland
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-03-01
End date: 2022-02-28
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Over the past 25 years deep brain stimulation (DBS) has emerged as an effective treatment for the symptoms of Parkinson's disease (PD). Despite its success, the mechanisms of DBS are not yet fully understood. Moreover, patients experience side effects and poor control of symptoms associated with suboptimal programming of stimulus parameters. Current DBS systems operate in an 'open-loop' configuration with stimulus parameters (pulse amplitude, duration and frequency) empirically set and remaining fixed over time. Closed-loop DBS offers an alternative approach that has the potential to overcome current limitations and increase therapeutic efficacy, while reducing side-effects and increasing battery life, by automatically adjusting stimulation parameters as required. Although the potential benefits of closed-loop DBS are widely recognised, these systems have not yet been implemented clinically. Under the parent ERC project DBSmodel, we have developed biophysically detailed computational models of the neural circuits in the brain during DBS and are using these to develop and test novel algorithms for closed-loop DBS. Before these can be trialled in humans, however, feasibility must first to be demonstrated through implementation on a prototype device and pre-clinical testing in animal models. ERC proof of concept funding will enable us to do this by implementing and testing a novel closed-loop DBS system in an animal model of PD. The experimental validation will confirm the efficacy of a prototype solution suitable for translation to human studies.

Keywords: deep brain stimulation,closed loop control,parkinson s disease,pre clinical testing,medical device
Fully connected virtual and physical perovskite photovoltaics lab (VIPERLAB)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Italy,Austria,Germany,Germany,Spain,Germany,Switzerland,Belgium,Switzerland,Belgium,Belgium,France,Netherlands,United Kingdom
Call: Integrating Activities for Starting Communities (H2020-INFRAIA-2020-1, 2020)
Start date: 2021-06-01
End date: 2024-11-30
Duration (months): 42.0
Total project cost (EUR): 5520124.75
EU funding (EUR): 5520124.75
Participants: 15
Project status: SIGNED

VIPERLAB identifies perovskite PV as the key emerging technology that will be the lever for a future market penetration of EU-based PV production with lowest costs and lowest carbon footprint. Therefore, through facilitated and coordinated access to the best EU perovskite infrastructures and the use of advanced data mining approaches, VIPERLAB will stimulate European academic and industrial researchers to work together on the research and development of the next generation of solar cell technology, which will accelerate the perovskite PV technology development in Europe. Top-level material synthesis, state-of-the-art device design and development, as well as standardized testing methods, simulation methods, and databases will be the main services offered in order to validate at lab-scale and at pre-industrial-scale, the technology that will form the backbone for EU PV recovered worldwide leadership all along the value chain. VIPERLAB will boost this ambition for the emerging perovskite community by providing transnational and virtual access aiming to: (1) combine European top-ranked, relevant and complementary perovskite PV infrastructures to foster perovskite solar cells and module development and testing. Facilitate access to these perovskite-focused infrastructures for the community of EU PV academia and industry; (2) connect and support the starting European perovskite community through physical and virtual infrastructures and through targeted networking activities and (3) further develop physical and virtual perovskite infrastructures, build an up-to-date database on materials and devices, on long-term performance and on environmental and economic impact (enabling evidence-based commercial and political decision making. Hence, VIPERLAB will build up a close dialogue with the emerging perovskite industry with the help of new initiatives such as EPKI as well as more established players such as the European solar industry association Solar Power Europe.

Keywords: perovskite pv,materials and device database infrastructures,transnational and virtual access,physical and virtual infrastructures
High sensitivity multi-gas handheld gas analysis technology (IRON)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Finland
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-2-2015, 2015)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 3351725.0
EU funding (EUR): 2346207.5
Participants: 1
Project status: CLOSED

GASERA, a high tech Finnish SME, aims to develop and commercialise the IRON handheld device for sub-parts per billion (ppb) gas detection based on proprietary mid-infrared laser spectroscopy combined with novel patented photoacoustic technology. The transitioning of its technology from fixed mount analysers to portable and handheld instruments, motivated by the strong need for portable analysers for toxic gases and air pollutants in several application fields with laboratory grade performance, will enable access to new markets. Existing technologies have limitations in terms of size, performance, versatility and/or usability. A miniaturized detector that offers both sensitivity and selectivity would enable a plethora of new applications (cargo container safety, indoor air quality monitoring, hidden person detection, explosives and narcotics detection, occupational safety, odour analysis, unknown chemicals identification, etc.) unlocking the floodgates to a multimillion euro business opportunity in the growing green economy, whereby there is increasing concern over the impacts of air pollution and air quality in the EU. Our first target application of fumigants and toxic industrial chemical measurement in cargo containers will generate ~ € 42.3 M in sales by 2023 and will enable ~38 high-end jobs to be created in Gasera. IRON will respond to growing demand for affordable, rapid, sensitive and selective instruments to enable on-site detection of hazardous chemicals in cargo containers and prevent worker exposure to the harmful volatile chemicals caused by fumigants and off-gassing of freight. The current lack of technology places dockworkers, container unloaders and consumers at risk of carcinogenic or toxic gases, many of which elude subjective detection. IRON will have the required sensitivity, selectivity and speed for providing quick, accurate and reliable readings of the type and quantity of chemicals inside to enable safe handling of contaminated containers.

Keywords: multi gas gas analyser,handheld device,mid infrared laser spectroscopy,photoacoustic technology,cloud data management,air pollution monitoring,occupational safety,indoor air quality
Multiscale study of the interactions between corona viruses of various pathogenicity and cell membrane components in the early stages of virus entry (CoVentry)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-05-23
End date: 2024-05-22
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: SIGNED

Coronaviruses (CoV) have been responsible for several severe viral outbreaks culminating in the current global pandemic. However, some viruses of this family are widespread and only cause mild conditions, like the common cold. The origin of the significant variation in the severity of the CoV-related diseases is still poorly understood. Recent studies have suggested that the strength of the interaction between the virus and the cell surface during the early stages of virus entry could play an important role. CoVs attachment to the plasma membrane is mediated by the specific interaction between the viral spike glycoprotein (CoV-S) and receptors found on the cell surface. In addition, several CoVs have been shown to interact with the cellular glycocalyx during the early attachment to the cell surface. In this proposal, I describe the study of the early entry mechanism of CoV-SARS, CoV-SARS2, and hCoV-NL63 which all target the same cellular receptor, angiotensin-converting enzyme 2, while strongly varying in their pathogenicity. The study focuses on the dynamics, kinetics and strength of the interaction of these viruses with the cell surface. It employs an incremental approach, from the study of the bond between individual CoV-S and single membrane components to multivalent interactions between the virion and the cell surface. A wide array of biophysical (e.g. single-particle tracking, and optical tweezer) and biological (e.g. viral pseudotypes) techniques are used, combining the host’s and my expertise. This multidisciplinary project will result in a unique and comprehensive characterisation of the interactions taking place during CoV-entry, it will elucidate the difference between viral species, and it will give insights into the origin of the observed differences in pathogenicity. In addition, this work will strengthen and expand my experience and network in the virology and biophysics fields, significantly improving my career prospects as an independent researcher.

Keywords: cov sars nl63 sars2 virus entry ace2 cov s spike optical tweezers tirfm spt hs gags
Elucidating the mechanisms, heterogeneity and role of epigenetic topological alterations in cancer (CancerEpiTopology)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Cancer genomics has revolutionized cancer research by systematic mapping of oncogenic genetic alterations of genes, yet oncogenic epigenetic alterations of regulatory elements away from genes remain elusive. I recently demonstrated that aberrant DNA methylation of CTCF binding sites perturbs chromosomal topology in IDH-mutant glioma and SDH-deficient gastrointestinal stromal tumors (GISTs). Loss of CTCF binding at the boundary between two topologically associating domains disrupts their insulation, leading to oncogene activation. This groundbreaking model links metabolic, epigenetic and topological alterations and demonstrates that they can drive oncogenesis. Aberrant DNA methylation is common in many tumors and therefore epigenetic CTCF disruption may play a role in other cancers, but this has not been studied to date. Prompted by my findings, recent advances in genome-wide characterization methods and newly available large-scale data, I now propose to systematically uncover the rules of regulation of DNA methylation at CTCF binding sites, and how its disruption in cancer leads to epigenetic heterogeneity and drives oncogenesis. To achieve that, we will develop new statistical models to systematically uncover the rules of regulation of DNA methylation at CTCF binding sites and its impact on topology (Aim 1); uncover mechanisms of epigenetic topological alterations and their role in cancer (Aim 2); and develop computational tools to study intratumor epigenetic heterogeneity to investigate the interplay between different subclones (Aim 3). Taken together, this research program will facilitate a systematic understanding of epigenetic topological alterations and their role in cancer. These are critical goals for the field in order to understand the events that drive cancer, to discover new biomarkers, dependencies and therapeutic strategies, and to inform epigenetic and other personalized therapies.

Keywords: cancer,epigenetics,chromosomal topology,cancer heterogenity,systems biology
Sustainable and efficient bio-chemical catalytic cascade conversion of residual biomass to high quality biopolymers (BioCatPolymers)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Innovation actions
Countries involved: Germany,Italy,Italy,Sweden,Switzerland,Greece,Netherlands,Netherlands,Netherlands,United Kingdom
Call: Optimisation of biocatalysis and downstream processing for the sustainable production of high value-added platform chemicals (H2020-NMBP-BIO-2017, 2017)
Start date: 2018-01-01
End date: 2021-06-30
Duration (months): 42.0
Total project cost (EUR): 5339235.08
EU funding (EUR): 4362047.5600000005
Participants: 11
Project status: CLOSED

The overall objective of BioCatPolymers is to demonstrate a sustainable and efficient technological route to convert low quality residual biomass to high added-value biopolymers. The technology is based on an integrated hybrid bio-thermochemical process combining the best features of both. The biological step consists of the efficient conversion of biomass-derived sugars to mevalonolactone (MVL). MVL can be then converted to bio-monomers via highly selective chemocatalytic processes. BioCatPolymers is specifically aiming at the efficient and economic production of isoprene and 3-methyl 1,5-pentanediol (3MPD), two momoners with very large markets that can be further processed in the existing infrastructure for fossil-based polymers for the production of elastomers and polyurethanes, respectively. This ambitious target will be attained by optimizing and demonstrating the entire value chain on 0.5 ton of biomass/day scale, starting from the pretreatment of lignocellulosic biomass to hydrolysis and biological fermentation to MVL, separation of MVL from fermentation broth, selective catalytic conversion to the targeted monomer and finally purification to polymer grade quality. The novel approach we propose in this project surpasses the impediments of traditional solely bio-based approaches. It aims at producing bio-isoprene at 50% cost reduction and 3MPD at 70% cost reduction compared to average market prices, by optimizing the platform cell factories and all downstream processes and integrating the process modules, thereby increasing the competitiveness of biological processes in terms of economics. The BioCatPolymers consortium consists of highly qualified and experienced researchers with complementary expertise. Trans-disciplinary considerations are strongly involved in the project. The strong industrial leadership-driven innovation potential is reflected through the fact that the large majority of the partners are from industry.

Keywords: mevalonate,bio monomers,isoprene,3 methyl 1,5 pentanediol,bio polymers,fermentation,hybrid bio chemocatalytic process
Expanding and widening customized design-based consumer goods access (EXPANDCUSTOM)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Spain
Call: New business models for inclusive, innovative and reflective societies (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-10-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

There is a lack of widely available, easy to use, e-commerce tools adapted to the idiosyncrasy of design-driven customised footwear. Customizable goods are not manufactured until the customer co-design/customize the product and makes a formal order: this implies the absence of physical samples, and supposes a huge number of possible functional, aesthetic and design combinations. Specialized tools are required to offer the customer the co-design possibilities, additional tools for virtual test and for fitting are required to mitigate the absence of physical samples, and specific e-commerce tools are required to adequately offer the product to the potential customer. A notable lack is the absence of a specific CSE (Comparison Search Engine) focused on customizable footwear. ExpandCustom make available to any customizable footwear manufacturer (no matter the big or the small they are) the opportunity to easily and competitively market their products in Internet, by means of a set of specialized tools that allow the fast deployment of a shopping site connected to a CSE focused on customizable consumer goods. ExpandCustom appears to the consumer and to the manufacturer as two sides of a mirror: -For the consumer is a specialized CSE: allow buyers to focus their Internet search on a unique location specialize in customizable footwear, rather than having to navigate through a huge number of sites. -For the manufacturer is a set of tools that allow an easy deployment of a shopping site integrated with existing ERP/CRM and with unassisted CSE feed of products, including functionalities specific to customizable products: co-design tool, virtual models creation/conversion, virtual materials, virtual tester tool and fitting tool. The CSE will be the driver of all Internet traffic to the manufacturer of customizable footwear, and the creation tools will be the brick of the shopping site.

Keywords: e commerce,comparison search engine,customizable,footwear,design driven