Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Networking for excellence in functional pharmacology to study the role of fatty acid metabolism in neurological disorders (FAT4BRAIN)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Germany,Austria,Sweden,Latvia
Call: Twinning (H2020-WIDESPREAD-2018-03, 2018)
Start date: 2019-11-01
End date: 2023-04-30
Duration (months): 42.0
Total project cost (EUR): 799406.25
EU funding (EUR): 799406.25
Participants: 5
Project status: SIGNED

The Latvian Institute of Organic Synthesis (LIOS) is in great need to enhance its scientific performance and this could be accomplished through stronger international collaboration within the defined National RIS3 specialization in biomedicine. Latvia is performing well below the EU-average in terms of research excellence and innovation scoreboard. The FAT4BRAIN project builds cooperation between LIOS from the Widening region and world leading partners in translational neuropharmacology (Uppsala University), metabolism and neuropsychiatric imaging research (Eberhard Karls University Tuebingen) as well as innovative mitochondria research company (Oroboros Instruments). The aim of FAT4BRAIN is to establish a network of excellence focused on the pivotal and common role of fatty acid metabolism in the development of neurological disorders, an issue of utmost biomedical and societal interest. FAT4BRAIN will use a multidisciplinary, functional pharmacology approach to promote cutting-edge research in this field. A comprehensive set of activities including workshops, expert meetings and dedicated trainings for early-stage researchers will enhance knowledge-bridging and networking. FAT4BRAIN activities will specifically focus on strengthening capacities in areas that need improvement at LIOS, using the internationally-leading partners’ excellence and experience. Dissemination of results to the research community, industry partners and public through presentations at conferences, media outputs as well as high impact publications will be facilitated by the partners’ extraordinary reputation and high-impact profile. Importantly, the research excellence of the partnering institutions together with the targeted activities of FAT4BRAIN will help LIOS to improve their own research profile by increasing methodological capacities in preclinical and translational research and scientific output in terms of publications of highest quality and impact.

Keywords: capacity building,networking,preclinical models,neuroscience,energy metabolism
ERNCIP CBRNE STANDARDS 2017 and 2018 – support to Mandate 487 (CBRNE STNDS 2017)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Protect and improve the resilience of critical infrastructures, supply chains and tranport modes
Action type: Coordination and support actions
Countries involved: Belgium
Call: Supporting the implementation of the Security Industrial Policy and Action Plan through the European Reference Network for Critical Infrastructure Protection (ERNCIP) (H2020-IBA-SC7-ERNCIP-2017, 2017)
Start date: 2017-06-01
End date: 2019-11-30
Duration (months): 30.0
Total project cost (EUR): 500000.0
EU funding (EUR): 500000.0
Participants: 1
Project status: CLOSED

The primary aim of this project is to improve the detection of CBRN-E substances in Europe by enhanced cooperation among European research laboratories, advancing common technology standards or detection processes. This goal will be achieved through four work packages, each addressing a specific CBRN-E issue. These work packages will be formed around an ERNCIP thematic group, which will undertake pre-normative assessment on the topics identified as having a priority need, driven by the current security threats faced in the EU. The proposed thematic groups for this CBRN-E Standards project are: • Chemical & biological risks to drinking water – Water Security Plan • Radiological and nuclear threats to critical infrastructure – remote expert support & novel detection technologies • Risk assessment and mitigation of explosive threats against structures and soft targets • Vehicle screening against explosive and weapons threats at checkpoints – CEN Workshop Agreement. In order to provide oversight across all these work packages, there will also be a management work package covering the ERNCIP Office’s specific activities which will oversee all the other work packages. Each thematic group will undertake pre-normative assessment to identify the current issues associated with the topic, and what options might exist for further harmonisation activities that would improve the security of the EU, and/or help the EU market for security products. In some cases, this may lead to recommendations for specific harmonisation activities, such as changes to existing standards, or even proposals for new standards. Other possible paths that could be identified include a CEN/CENELEC workshop agreement; recommendations for further research, recommendations for EU policy, or even recommending that no further activity is justified.

Keywords: security,water,cbrne,chemical,biological,radiological,nuclear,explosives,emerging technologies,reachback,structural risk assessment,vehicle screening,soft targets,counter terrorism
Highly customizable robotic solutions for effective and safe human robot collaboration in manufacturing applications (FourByThree)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Spain,Germany,Germany,Italy,Spain,Finland,Netherlands,United Kingdom,United Kingdom
Call: Symbiotic human-robot collaboration for safe and dynamic multimodal manufacturing systems (H2020-FoF-2014, 2014)
Start date: 2014-12-01
End date: 2017-11-30
Duration (months): 36.0
Total project cost (EUR): 6859721.75
EU funding (EUR): 6305517.0
Participants: 17
Project status: CLOSED

Industrial robots have demonstrated their capacity to answer the needs of many industrial applications, offering a high degree of dexterity, accuracy and efficiency. However, when the application requires the collaboration between the robot and the worker, including workspace sharing, it is not feasible to use standard industrial robots due to safety being compromised Recently, new robotic products have appeared on the marked claiming to be safe when used in the vicinity of humans, offering the possibility to control the force exerted in case of collision. However they lack the flexibility (in terms of possible physical configurations) or are very expensive. Furthermore, even these robots are offered as isolated products without rich perception capabilities or adequate responsive behaviours that have to be developed by the system integrators for any new manufacturing process. FourByThree proposes the development of a new generation of modular industrial robotic solutions that are suitable for efficient task execution in collaboration with humans in a safe way and are easy to use and program by the factory worker. Consortium partners in this proposal have already achieved relevant results in different technologies that are fundamental to solving the outlined problem of automating the factory floor by means of modular robots, collaborating with human workers. The approach is to adapt those results, make them more reliable and integrate them in order to achieve the final goal of the project. The acronym of the proposal refers to the two main foci of the proposal: the FOUR main characteristics of FourByThree (Modularity, Safety, Usability, Efficiency) and the THREE main actors (Humans, Robots, Environment) in the manufacturing scenarios. The proposal outlines a Business Model and a Business Plan that will be further elaborated through the project.

Keywords: robot,safety,interaction,control,collaboration,programming,manufacturing
The first manufacturing process to obtain reduced graphene oxide at large-scale (perGOla)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-10-01
End date: 2020-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Despite its unique properties, graphene is relatively chemically inert, but its derivatives, graphene oxide (GO) and reduced graphene oxide (rGO) are much more reactive and attractive for industrial applications. rGO bears some remnant oxygen groups and holes that allow the possibility of functionalisation. Tailoring the oxygen content in rGO (C/O-ratio) controls its properties and modulates its performance, therefore, the capability of controlling the C/O-ratio is crucial. The challenge is that rGO is not widely available at a commercial scale, even with a clear and identified market need for graphene derivatives. The Graphene Council identify 3 main barriers to commercialisation for graphene derivatives: cost of production; limitations of large-scale production and lack of quality assurance standards. Abalonyx will address these challenges through the perGOla project by: 1) Reducing the production cost of rGO to 100-400 €/kg (from 2,500 €/kg) 2) Increasing the large-scale production of rGO up to ~4 kg/day (1,200 kg/year) through the first industrial automated manufacturing process. 3) Offering the most reliable rGO production line in the market since perGOla process will use GO manufactured in-house 4) Increasing the C/O- ratio up to 100, and tailoring the C/O-ratio and number of layers in the rGO Abalonyx, leader in graphene sector, is a worldwide supplier of GO and rGO to research institutes, universities, SMEs such as Provexo, and “big players” such as ABB, Apple INC, and Tata Steel. 15% of our customers are recurrent customers. We have strong support from end-users such as Qenos, an Australian composite manufacturer who is interested in large amounts of rGO, or European Thermodynamics Limited, who requires rGO at a cost-effective price for the development of thermal interface materials, will help us to accelerate the commercialisation of perGOla. Within 6-years of commercialization, we expect €25m of cumulative profit to achieve an ROI of 11.5.

Keywords: reduced graphene oxide,bespoke properties,carbon to oxygen ratio,large scale production,automated manufacturing process,low production cost,tunable reactor
In-situ thermal rock properties lab (ITHERLAB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2019-04-02
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The ITHERLAB project investigates the influence of in-situ (present state in the geological subsurface) pressure and temperature on rock thermal properties (thermal conductivity and thermal diffusivity) as one of the essential thermal properties in the evaluation of the Earth thermal field. The ITHERLAB project will establish mathematic formulations for p/T dependence of both parameters and demonstrate whether micro-structural effects affect these relations for different rock types. For that purpose, an innovative laboratory device will be developed and pilot-tested allowing for dry and saturated rocks measurements of thermal conductivity and thermal diffusivity at pressures and temperatures that are simultaneously raised to values up to 200 MPa and 200°C, respectively. These are the conditions for depths (to approx. 7 km), which are of interest in the use of Earth resources (such as geothermal energy, hydro-carbons, storage of energy or waste). Currently, no laboratory standard procedure exists for this task. Precise knowledge of reliable in-situ thermal rock properties and derived thermal parameters (e.g. heat-flow density) is in-dispensable for understanding the Earth’s subsurface thermal structure and heat budget. Heat mainly drives geody-namic processes (e.g. mantle convection, plate tectonics). Practical implications for the society are arising for exam-ple from the extraction of the Earth’s heat for heating purposes or electricity generation and from the subsurface storage of heat to compensate different seasonal energy demands - techniques that can help to secure and diversify Europe’s energy supply. Moreover, knowledge and methods provided by the ITHERLAB project are paramount for the planning, management and realization of any scientific and industrial subsurface application, which is affected technologically or economically by the subsurface thermal field (temperature and heat budget).

Keywords: in situ rock thermal properties,thermal conductivity,thermal diffusivity,earth thermal field,laboratory device
Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity (EarlyCause)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Spain,Italy,Germany,Switzerland,Finland,Finland,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Understanding causative mechanisms in co- and multimorbidities combining mental and non-mental disorders (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 5997381.25
EU funding (EUR): 5997381.25
Participants: 14
Project status: SIGNED

EarlyCause will identify and demonstrate causative mechanisms and molecular pathways linking early life stress (ELS) to depression and two of its main physical comorbidities, namely coronary heart disease and diabetes. The consortium will disentangle the complex biological contributions from four key interconnected domains linked to ELS, namely epigenetics, inflammation, neuroendocrine system, and microbiome. Furthermore, modifying effects of environmental factors such as sex/gender, socioeconomics, lifestyle and behavior will be quantified, thus uncovering potential intervention targets that may reverse the causative mechanisms and reduce the impact of ELS on multi-morbidity development in high-risk individuals. To achieve the goals of the project, this highly multi-disciplinary and experienced consortium will combine state-of-the-art and novel approaches from basic, pre-clinical and clinical research, including causal inference methods such as Mendelian randomisation, animal models of prenatal and postnatal stress, cellular models in various tissues, and integrative bioinformatics and machine learning methods. The consortium members will also enable access and exploitation of the largest set of European cohorts, comprising rich information on early stressors, biological and omics data, as well as depressive, cardiovascular and metabolic phenotypes. Generated data, tissue samples, experimental protocols and cell lines, as well as best practices, will be compiled and integrated into a new open-access research platform within ELIXIR to support future researchers in the emerging topics of ELS and multi-morbidity. Finally, the project will ensure the research, clinical and socioeconomic impacts are adequately quantified and translated to allow full exploitation of the identified biomarkers and innovation outputs, in particular in relation to new integrated care pathways taking into account ELS-induced multi-morbidity in clinical practice.

Keywords: multi morbidity,depression,cardiovascular disease,metabolic disorder,early life stress,epigenetics,microbiome,causal inference,animal models,cellular models,machine learning
Regulating Pathological Neural Connectivity in Posttraumatic Stress Disorder (PTSD Neurofeedback)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-03-15
End date: 2022-03-14
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: CLOSED

Posttraumatic stress disorder (PTSD) is a debilitating and prevalent psychiatric illness that develops after exposure to a traumatic event, and involves symptoms of severe intrusive recollections and flashbacks related to the trauma, hyperarousal and reactivity, avoidance, and negative alterations in cognitions and mood. Indeed, patients with PTSD are characterized by decreased prefrontal cortex (PFC) regulation on hyperactive emotion generation regions, such as the amygdala and brainstem. Real-time fMRI neurofeedback allows for brain regions to be self-regulated through neuroimaging signal feedback. Recently, the experienced researcher has shown that learning to decrease amygdala activation via real-time fMRI neurofeedback leads to a normalization of pathological neural circuitry maintaining PTSD, which was negatively correlated to symptoms. Critically, however, an intervention has not yet been developed to directly target suboptimal connectivity between emotion regulation regions (PFC) and emotion generation regions (amygdala and brainstem), where an urgent need for novel treatment interventions exists particularly among individuals suffering from PTSD. The objective of the current proposal is to determine the treatment efficacy of increasing the strength of connectivity from the PFC to the amygdala and brainstem via a real-time fMRI neurofeedback randomized clinical trial (RCT). Here, connectivity signals will be relayed back to the participant in the scanner as a simple thermometer that changes as directed connectivity between brain regions-of-interest fluctuate. Participants will be asked to self-regulate the neural signal displayed by the thermometer in real-time during PTSD emotion induction paradigms. The proposed study has the potential to develop into a novel treatment for PTSD, and is in line with current European research trends and societal needs to decrease the economic resources required to support mental health treatment.

Keywords: posttraumatic stress disorder,neurofeedback,real time fmri,dynamic causal modelling,psychiatry,amygdala
Powerstar Virtual Power Station (PVPS) solution - Powerstar Virtue (PVPS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: United Kingdom
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-2-2014, 2014)
Start date: 2015-07-01
End date: 2018-07-31
Duration (months): 37.0
Total project cost (EUR): 2365407.5
EU funding (EUR): 1655785.25
Participants: 1
Project status: CLOSED

EMSc(UK) Ltd is the designer and manufacturer of the Powerstar voltage optimization (VO) system, one of the top recognised energy saving technologies. Powerstar, is the only VO system in the world with a Patent granted on its design (Pat. No.1014460.8.), and is a global leader in the VO market. With more than 6.500 Powerstar installations worldwide, the company is in an ideal position to expand its business in this important new emerging market for Smart Grid Virtual Power Stations. Powerstar Virtue aims to pilot-test an integrated smart grid solution based on the Powerstar system design with storage mediums and renewable energy sources. This new solution will open up significant new market opportunities for the company in the European and international markets. The company has been working since 2011 in an R&D project with Warwick University to enhance the functionalities of its Powerstar system in order to harness the saved power (resulting from Powerstar VO) and divert it into a storage medium. This R&D project has led to the development of the Powerstar Storage system (Patent pending) which will be launched in February 2015. This is a unique functionality for any VO system, enabling the company to enter the Virtual Power Station market and remain a leader in VO technologies. The Powerstar Virtual Power Station (PVPS) solution to be pilot-tested under this project will ensure the long term expansion of the company's market opportunities and will enhance the current EU plans for Smart Grid applications. The pilot will evaluate and demonstrate the benefits of the PVPS solution at a commercial site in a live operational environment (ASDA - Longwell Green Superstore). This will ensure that the user (ASDA) and the DSOs (National Grid through E.On) have a clear understanding of the value of the PVPS solution. Such a live demonstration will open up the market opportunity for the full commercialization of the PVPS solution.

Keywords: voltage optimization,virtual power station,energy storage,renewable energy,energy savings,energy efficiency,reliable supply,grid independence,smart grid