Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Species-specific aspects in eukaryotic mRNA translation modulation and their implications in diseases (SpicTrans)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 1999539.0
EU funding (EUR): 1999539.0
Participants: 1
Project status: SIGNED

mRNA translation is a universally conserved process consisting on translating the genetic code into proteins, the primary building blocks of all living organisms. Translation is mainly operated by the ribosome, a hybrid molecule made of RNAs and proteins. In most eukaryotes, at least two types of mRNA translation coexist in nearly all cells. Indeed, although the quasi totality of the proteins is translated in the cytosol by the cytosolic ribosome, a small yet essential fraction of mRNA translation can take place in the mitochondria, the cell’s power plant. While mitochondrial translation process has proven to be substantially species-specific, numerous species-specific structural and regulatory differences also exist in the cytosolic translation process in spite of their relative conservation among eukaryotic species and are yet to be elucidated. We will use various structural and molecular biology methods to investigate, from a disease-related perspective, several species-specific aspects of mRNA translation modulation in mammals and in pathogenic parasites from the family of kinetoplastids. Namely, 1- we will investigate the molecular roles of several kinetoplastid-specific proteins involved in translation and evaluate their validity as pharmacophores. 2- We will study mitochondrial translation in kinetoplastids and focus on its variable regulation in different forms of the parasites during their life-cycle (blood vs. insect stages). 3- We will study cytosolic mRNA scanning for the start-codon during translation initiation to i) understand its molecular basis in different types of mRNAs (native and modified mRNAs, natural or artificial), ii) and investigate its alteration in colorectal cancer caused by the absence of a ribosomal RNA modification. Results will advance our knowledge of species-specific mRNA translation and open new perspectives for developing treatments against various human diseases and infections (anti-parasites, cancer therapy, mRNA vaccines).

Keywords: kinetopladtides,species specific mrna translation modulation,cytosolic ribosome,mitoribosome,atp synthase,kozak sequence,translation initiation,cryo em,form differentiation in trypanosomes
Inclusive and Interconnected Ecosystem to Boost Paediatric Innovation in Europe-i4KIDS-EUROPE (i4KIDS-EUROPE)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Spain,Latvia,Poland,Denmark,Finland
Call: Towards more inclusive networks and initiatives in European innovation ecosystems (HORIZON-EIE-2022-CONNECT-01, 2022)
Start date: 2023-01-15
End date: 2025-03-14
Duration (months): 26.0
Total project cost (EUR): 562160.71
EU funding (EUR): 505375.0
Participants: 9
Project status: CLOSED

Innovation in paediatric health is critical to ensure that children, regardless of their age, health condition, socio-economic situation or place of birth, have access to the life-changing healthcare solutions they need to grow-up stronger and contribute to a better society. Children are not just small adults and they need targeted innovative solutions. However, paediatric innovation is still elusive. There are two main causes for this: i) Stakeholders perceive paediatric innovation as risky and they just try to adapt adult solutions to children. ii) Paediatric experts, innovators and other relevant stakeholders are scattered in a fragmented ecosystem across Europe failing to identify opportunities or deliver effective and harmonized action. Thus, the unexploited innovation potential is large, particularly in emerging and moderate innovator countries. To reduce barriers and exploit these opportunities, while ensuring equality across different countries, the establishment of a European Paediatric Innovation Ecosystem is of paramount importance. The i4KIDS-EUROPE project builds on an existing successful initiative (i4KIDS), and it will expand its activities towards Europe in order to enlarge the participation of diverse European paediatric stakeholders and territories. The project will allow synergies, avoid duplications, reduce differences between strong and emerging/moderate innovator territories and strengthen competitiveness to optimise the innovation potential of the European paediatric sector. To achieve this, we will analyse the landscape of paediatric innovation in Europe as well as the barriers that emerging/moderate innovator countries face. i4KIDS-EUROPE will offer an interconnected paediatric innovation ecosystem that will capacitate its underrepresented actors and make them participate in the design of the future European Paediatric Innovation Ecosystem.

Keywords: paediatric innovation,paediatrics,participatory ecosystem,emerging and moderate innovator countries,capacity building
Glass at the Time of the Crusades: A new source for the socio-economic history of the Levant? (CRUSADERGLASS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 216240.0
EU funding (EUR): 216240.0
Participants: 1
Project status: SIGNED

The so-called Mediterranean “commercial revolution” of the central middle ages coupled with the Crusader occupation of the Levant utterly reshaped the region's socio-economic landscape, leading to an increase in commercial exchange and markets, urban production and socio-cultural interaction. This project uses the important evidence from glass to assess technologies of production and patterns of circulation and trade in a period of significant change. Through an interdisciplinary approach that integrates chemical analysis, archaeological evidence and historical records, I will investigate the contribution that glass can provide in shielding new light on the complex and poorly understood socio-economic relationships in the medieval Levant.

Keywords: medieval glass,islamic glass,crusader archaeology,economic history,la icp ms analysis,isotopic analysis
From RNA-peptide coevolution to cellular life at heated air bubbles (BubbleLife)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-04-01
End date: 2031-03-31
Duration (months): 72.0
Total project cost (EUR): 5972920.0
EU funding (EUR): 5972920.0
Participants: 2
Project status: SIGNED

The origin of life on Earth is one of humanity's profound mysteries that lacks scientific answers. We aim to answer this fundamental question by performing pioneering experiments starting from the Darwinian evolution of RNA and peptides to the emergence of cellular life, all in a single environment with only a small selection of starting molecules. We are an interdisciplinary team with diverse backgrounds in chemistry, physics, and biochemistry, and we have a proven track record of strong interdisciplinary collaborations. Preliminary experiments have revealed the remarkable potential of heat-exposed air bubbles for molecular evolution. BubbleLife connects long evolutionary timescales through targeted experiments, bridging from amino acids and nucleotides to the emergence of protocellular life in one unified environment. Our experimental studies indicate a chemical cooperation of amino acids, nucleoside monophosphates and lipids, driving their Darwinian co-evolution towards modern biochemistry. The non-equilibrium at heated air bubbles promotes RNA oligomerization and template-directed ligation, fostering the emergence of autocatalytic replication networks, including the first RNA catalysts (ribozymes). Co-accumulating lipids form membrane vesicles at heated air-water interfaces that autonomously encapsulate RNA. Driven by prebiotic phosphorylation, amino acids polymerize into peptides in the same alkaline environment. Subsequently, they form RNA-peptide hybrids, revealing intriguing modes of early proto-translation. By combining our unique expertises in a synergistic manner, our work will ultimately culminate in "protocell generators" that feed and encapsulate not only primitive RNA-based replicators, but also modern transcription-translation-based systems. BubbleLife will reshape our understanding of the origin of life on Earth and potentially elsewhere in the universe.

Keywords: prebiotic chemistry,origins of life,rna,lipids,peptides,ribozymes,cell free systems,in vitro translation
COST: Europe's most empowering research programme Strengthening science and innovation through research networking (SGA2)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: European Cooperation in Science and Technology
Destination: European Cooperation in Science and Technology
Action type: Coordination and support actions
Countries involved: Belgium
Call: Implementation of COST actions - Specific Grant under Framework Partnership Agreement (HORIZON-WIDERA-2024-COST-SGA, 2024)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 120000000.0
EU funding (EUR): 120000000.0
Participants: 1
Project status: SIGNED

Founded in 1971, COST is an intergovernmental framework for cooperation in science and technology (S&T). As defined in the COST Mission statement, COST provides networking opportunities for researchers and innovators in order to strengthen Europe’s capacity to address scientific, technological and societal challenges. To do so, COST funds bottom-up, excellence-driven, open and inclusive networks for peaceful purposes in all areas of science and technology. According to COST Vision statement, COST is aiming to become the leading open networking tool in the ERA. To continue to pursue its Mission and Vision, the COST Strategic Plan defines three strategic priorities for the remaining part of Horizon 2020 and in Horizon Europe: - Promoting and Spreading Excellence - Fostering interdisciplinary research for breakthrough science - Empowering and retaining young researchers and innovators To implement those strategic priorities, COST focuses its efforts on strengthening its core business and implementing a range of complementary activities. The COST Association is the beneficiary of a Coordination and Support Action (CSA) following the Horizon Europe Work Programme 2023-2025. The COST Association is an AISBL under the Belgian law with an integrated governance, management and implementation functions, creating the base for a responsible and accountable organisation where the COST Full Members have direct control. The legal and financial frame for the COST Association operations is provided via a Framework Partnership Agreement (FPA) and subsequent Specific Grant Agreements (SGAs). An overall budget of EUR 120 million is foreseen for the second SGA2 for a duration of 24 months, 1 November 2024 to 31 October 2026.

Keywords: networking,excellence driven networks,open and inclusive networks
NUTRIclock: a tool based on microbiome and artificial intelligence for implementing precision nutrition. (NUTRIclock)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-09-30
Duration (months): 28.0
Total project cost (EUR): 186332.93
EU funding (EUR): 186332.93
Participants: 1
Project status: SIGNED

The aging process is nowadays the major risk factor for chronic diseases. Understanding its mechanisms and developing interventions to modulate it constitute a major challenge in order to increase both our life and healthspan. The nutritional interventions have arisen as a potent instrument to influence aging mechanisms. However, the great variability of the effect of nutrition in different persons requires the development of proper tools to characterize the impact of a nutritional treatment. Here, we propose the development of NUTRIclock, an algorithm based on the latest advances in artificial intelligence and microbiome data directed to implement personalized nutrition by characterizing the effect of nutritional interventions on the aging process and health status of an individual. NUTRIclock will be the first algorithm designed to specifically address the interaction of nutrition with aging and the specific changes occurring in the microbiota. We have conceived this project as the opportunity to develop an instrument useful to implement precision nutrition strategies. It will be highly translational both in the design of public health plans through the application of efficient and personalized treatments, but also for the development in the food industry of new products and approaches to enhance the precision nutrition field. The implementation of this project will require the combination of the expertise in biocomputing of the hosting group and my background in molecular sciences and aging signaling. Importantly, I will strengthen my current bioinformatic knowledge, increasing my capacity to develop scientific projects making use of this powerful tool. In addition, I will sharpen my communication skills, instrumental for the dissemination of our work to the scientific community and the society. This project will enhance my professional career and help me to become an independent researcher in the nutrition, aging and bioinformatic field.

Keywords: nutritional interventions through precision nutrition approach
PSEUDOPIN (PSEUDOPIN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-05-01
End date: 2024-04-30
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: CLOSED

Pseudouridine (Ψ) is abundant in major classes of non-coding RNA (ncRNA), including ribosomal RNA, transfer RNA, and spliceosomal RNAs. The Watson-Crick base pairing potential of Ψ is identical to that of uridine, but Ψ may stabilize RNA structures and engage in RNA interactions distinct from those of uridine, probably explaining its requirement for cellular viability. In addition to the many constitutive Ψ-sites in major ncRNAs, recent reports have uncovered Ψ induced by specific stimuli or present in specific cell types, in rare cases with demonstrated importance for cellular translation and splicing patterns. Nonetheless, the full extent of occurrence and regulatory consequences of induced pseudouridylation remain unknown, highlighting the outstanding potential for discovery on this topic. PSEUDOPIN builds on my observation that the gene encoding PseudoUridine Synthase PUS5 in the plant Arabidopsis thaliana exhibits mRNA isoform switching upon immune receptor activation: in growing seedlings, PUS5 encodes an organellar enzyme, but immune receptor activation induces transcription initiation at a downstream site to exclude the organellar target peptide from the PUS5 protein, thus giving rise to a nucleo-cytoplasmic enzyme. Two questions are being investigated here: (i) can we identify PUS5-dependent Ψ-sites upon immune receptor activation, and (ii) can we define functions of selected induced Ψ-sites in the growth-to-defense genetic reprogramming? PSEUDOPIN uses state-of-the-art sequencing methods, including direct RNA sequencing technology, to systematically map Ψ in major RNA classes after immune receptor stimulation. It also lays out strategies to select and study particularly interesting cases. The topic remains completely uninvestigated in plants, so the project promises to break open a new research field within plant gene expression, and thereby provide material to start an independent research career following successful completion of the fellowship.

Keywords: rna,epitranscriptomic,nucleotide modification,pseudouridine,plant innate immunity,srnas,pus
The Hidden Weapon. Blockade in the Era of the Two World Wars (BLOCKADE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Norway,Germany,Netherlands
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-05-01
End date: 2031-04-30
Duration (months): 72.0
Total project cost (EUR): 9881766.0
EU funding (EUR): 9881766.0
Participants: 4
Project status: SIGNED

The main aim of BLOCKADE is to investigate how blockades shaped the course, outcome and aftermath of the world wars. In both wars, belligerents sought to blockade their enemies, cutting them off from vital resources such as food, oil, information and capital to hasten their defeat. Existing research is contradictory and fragmentary, leaving us in the dark as to the scope and the effects of blockades, just as the world is confronted with new blockades. Our hypothesis is that understanding the blockades is critical to the era of the world wars (ca. 1900-1960). The blockades affected societies the world over, testing their resilience and vulnerability. They produced new forms of violence and humanitarian care, prompted innovation and learning, and had integrative and disintegrative effects on wartime societies, alliances and the world order. The project’s ambitious approach transcends the traditional fixation on western Europe and integrates actors long seen as ‘peripheral’. It connects the disparate histories of the First and Second World Wars in a single explanatory frame by uncovering the shared generational experiences and learning processes related to blockades, allowing us to assess their impact on the wars and the peace that followed them. The high gain promised by this project comes with the high risk that we might fail to separate the impact of blockades from other effects of warfare; but it is a risk we believe we can mitigate via innovative methodology and careful source analysis. BLOCKADE requires input from a range of academic disciplines (economics and economic history, international history, cultural and war studies, statistical and digital analysis and many languages). Only the synergy resulting from combining the four PI and the larger team’s different qualifications and research methodologies will realise the potential for high scientific gains with the necessary complexity and range.

Keywords: first world war,second world war,aftermaths of war,globalization,deglobalization,violence,humanitarianism,resilience,international order,innovation
ROHS-compatible Low-cost Narrow bandgap Colloidal Nanocrystals for Infrared Photovoltaics and Photodetectors (CIRPH2) (CIRPH2)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-16
End date: 2027-07-15
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 1
Project status: SIGNED

Solution-processed photovoltaics and photodetectors have attracted significant attention in the last decades as a result of their ease of manufacturing and low cost. Colloidal nanocrystals form a special group of materials that can be utilized in the production of solution-processed devices thanks to their tunable bandgap, high absorption coefficient, composition tunability and their ability to form nanoheterostructures. Although this technology is very promising in terms of cost effectiveness and large-scale production of consumer goods, its wide-spread utilization in devices that operate in the infrared region of the electromagnetic spectrum is hindered due to the lack of environmentally-friendly materials with narrow bandgap. Current attempts typically employ lead- and mercury-containing semiconductors as the light-absorber, which complicates their utilization in large-scale applications as these materials do not comply with the European directive on the restriction of hazardous substances (RoHS). This project aims at developing narrow bandgap colloidal nanocrystals that will be used in the productions of RoHS-compliant photovoltaics and photodetectors. Within this project we are going to implement: i) a facile synthesis method for colloidal nanocrystals that do not contain any lead (Pb), cadmium (Cd) or mercury (Hg), ii) deposition and characterization of photovoltaics quality thin films of these colloidal nanocrystals via solution-processing methods and iii) fabrication and characterization of low-cost solution-processed photovoltaics and photodetectors based on these environmentally-friendly nanocrystals.

Keywords: colloidal nanocrystals,rohs,low cost,green energy,photodetectors