Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Revealing the structure and mechanism of mitotic chromosome folding inside the cell (MITOFOLD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-08-01
End date: 2029-07-31
Duration (months): 60.0
Total project cost (EUR): 3118430.0
EU funding (EUR): 3118430.0
Participants: 1
Project status: SIGNED

Mitosis is a fundamental biological process every cell undergoes at least once. It requires a dynamic and dramatic restructuring of the genome from extended interphase chromatin to compact individual mitotic chromosomes capable of faithful segregation. Altered nucleosome interactions, phase separation and loop extrusion have all been proposed to play important roles in shaping mitotic chromosomes. However, what the internal architecture of single mitotic chromosomes is, and how this architecture is established in space and time by different forces inside the cell remains unclear. This lack of knowledge precludes a comprehensive mechanistic understanding of mitotic chromosome folding and unfolding. This project aims to resolve the folding principles of chromosomes during mitotic compaction and decompaction in situ, in single human cells. To achieve this, we will combine newly developed nanoscale DNA tracing technology with quantitative single protein imaging approaches to achieve a systematic structural analysis of mitotic chromosome folding throughout mitosis. We will investigate when and where which structural features are first established, and then use targeted, acute perturbations to dissect which regulators are required to form and maintain them. The resulting data will provide an in situ structure-based model to explain the essential function of the genome in mitosis and will allow us to understand the spatio-temporal coordination of the underlying molecular and physical mechanisms. Overall, the proposed project will provide a new framework for understanding the physiological and pathological roles of mitotic chromosome restructuring during cell division.
Computing with Light and Sound (SOUND-PC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2998560.0
EU funding (EUR): 2998560.0
Participants: 2
Project status: SIGNED

In contemporary times, intricate challenges, whether they pertain to climate dynamics or economic processes, necessitate the handling of big data and sophisticated intelligent systems. At the core of these systems are digital neural networks that can undergo training. Neural networks based on photonic connections can be an adequate alternative, as they come with a broad bandwidth, high processing speed, and integrability with existing electronic chips. However, so far optical neural networks are mostly based on fixed elements whose connections are difficult to reconfigure. In my project SOUND-PC, I aim at creating an alternative architecture to control the photonic siblings of neural networks and will pioneer the approach of using light-sound interactions for the implementation of an optical neural network. The basis for this project lays in nonlinear optics, optoacoustics, stimulated Brillouin scattering, and optical computing. The main goal of SOUND-PC is to experimentally demonstrate several approaches which use the interaction of traveling acoustic waves with light waves for optical neural networks. This concept has the potential to enable a highly reconfigurable computing architecture in one single optical waveguide that can use inputs in the frequency, spatial or time domain with flexible connection of nodes based on optoacoustic interaction. These approaches can potentially be transferred to the quantum domain and contribute to the new emerging field of quantum neural networks. To achieve the main goal of SOUND-PC, I will harness nonlinear optical effects and optoacoustic interactions to address the following objectives: 1) Optoacoustic computing in the frequency domain 2) In-network computing realized by a distributed optoacoustic approach 3) Mode-processor in the spatial domain via topological-selective Brillouin scattering 4) Feasibility study of transferring optical computing architectures to the quantum domain.

Keywords: nonlinear optics,stimulated brillouin scattering,optoacoustics,optical computing,optical signal processing,optical neural networks,fiber optics,integrated optics
Towards development of new antibacterial strategy for dentistry (ARGO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Latvia,Ukraine,Sweden,Poland,Lithuania
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 990314.29
EU funding (EUR): 915400.0
Participants: 6
Project status: SIGNED

ARGO project will be dedicated to explore innovative activities with focus on strong international, interdisciplinary and inter-sectoral cooperation in fields of chemistry, biomaterials, nanotechnology, microbiology, cell biology and dentistry. ARGO network will involve academic and industrial partners from EU MS and associated countries with the aim to open potential for innovative solutions in nanomaterials and clinical dentistry. The primary research goal of the project is to facilitate R&I activities with complementary competences of participant organizations for development of new antibacterial materials for dentistry, particular for the development a new antibacterial root-filling material. The project will be realized through the tight cooperation between partner organizations to create synergies for development and testing of innovative biomaterials for dentistry. The innovative technologies will be used to produce a root-filling material with nanoparticles with tailored biological and antibacterial properties. Evaluation of a new biomaterials with silver nanoparticles in vitro will be carried out on a specially designed tooth model. Biocompatibility and in-vivo assessment will be used to prove antibacterial effect of the new biomaterial on a relevant animal model. Interdisciplinary and inter-sectoral secondment will be the main tool for project realization with aim of strengthening research, training, communication and networking capacities of participant organizations and knowledge transfer from academia to industry and vice versa. Proposed research and training goals will lead to increased research, transferable skills and competences of early stage researcher with the aim to improve employability and career perspectives in both academic and industrial sectors. Public dissemination of new research results will increase the awareness in the general society of the role of research and researchers in development of EU as a leading destination for R&I.

Keywords: dental materials,oral health,antibacterial,silver nanoparticles,biocompatibility,bacterial resistance
Variations In Motivation Across the Day - Understanding the How and Why of Daily Fluctuations (VIMAD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

Life on earth has evolved in synchrony with the day-night cycle. Most species, from single-cell plants to humans, have a circadian system that operates as a pacemaker, modulating a multitude of biological processes across the 24h period. Given the ubiquitous involvement of the circadian system in our physiology, it is not surprising that motivation and related neural systems such as dopamine also vary across the day, but with large variation between individuals. Time-of-day is increasingly being utilised to strengthen treatment effects and facilitate behavioural change. However, we still lack fundamental mechanistic knowledge for establishing more effective and widespread therapeutic applications in mental health care as well as in daily life. Hence, there is a need to more fully understand the circadian clock of motivation and drive. The objective is, first, to predict “when” (i.e., at which time of day) drive and motivation are heightened and blunted, and second, to scrutinise the underlying cognitive and neural mechanisms. Specifically, in phase 1, I plan to conduct a large-scale field study using a mobile application to quantify fluctuations in motivation to engage in daily-life behaviours and cognitive mechanisms including incentive motivation, reinforcement-learning, and cognitive flexibility. Then, in phase 2, I will use this knowledge to probe the role of dopamine in time-of-day effects of motivation by pharmacologically modulating dopamine at different times of day in a subset of the participants from phase 1. The combination of field research and basic experimental research will provide unique and clarifying knowledge of how and why motivation fluctuates both within and between individuals. Given the significant role of motivation in the healthy and sick brain, the results will provide novel valuable insights for the society at large.

Keywords: chronobiology psychobiology chronotype psychopharmacology dopamine motivation
Balancing Adaptive Cooperative Technology (BalancingACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-08-01
End date: 2025-07-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

Balance impairment affects a large proportion of the global population, as a symptom of many neurological diseases and a consequence of advanced age. Methods to improve balance through rehabilitation or assistive devices are effective but are limited by the availability of physiotherapists or by the strength and agility of the patient. While robotic assistive devices could augment mobility, extensive training is often necessary to receive the full benefits. BalancingACT will tackle this bottleneck by investigating methods to facilitate co-adaptation of user and balance assistance, providing personalized assistance directly targeting balance outcomes. The GyBAR, a gyroscopic backpack, has improved standing and walking balance for both healthy and stroke populations, but could benefit from targeted user training. BalancingACT will address three main aspects of human-robot co-adaptation. I will first examine existing datasets from healthy and patient populations to determine which balance metrics explain differences between populations, providing a measure to gauge and optimize human-robot co-adaptation. I will then probe methods to improve motor learning for a healthy population in a challenging task, i.e., walking along a narrow beam. Exploration, driven by the individual or by the device, is a vital component of early learning. I will conduct two experiments, one to understand how self-guided exploration affects learning and one using human-in-the-loop optimization, a method to customize assistance by directly estimating the user’s response to a variety of candidate controllers, to determine the benefits of device-led exploration. This algorithm has previously elicited positive learning effects in exoskeletons and can also provide insight into the third aspect of co-adaptation: adapting the device to the user. In the long term, these results can be used to not only improve outcomes for the GyBAR but can also be generalized to other balance assistive devices.

Keywords: rehabilitation,balance,motor learning,robotics
Advanced Acoustic Liners Concept: An innovative Approach to Predicting Sound Propagation Using Physics-Improved Time-Domain Impedance Boundary Conditions (LinerFun)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Australia,France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-05-01
End date: 2029-04-30
Duration (months): 36.0
Total project cost (EUR): 309153.72
EU funding (EUR): 309153.72
Participants: 3
Project status: SIGNED

Aircraft engines generate significant noise during takeoff and landing, prompting the use of acoustic liners (ALs) in engine nacelles for noise reduction. However, conventional ALs are inadequate for modern Ultra-High Bypass Ratio (UHBR) engines, which require thicker liners to cope with lower fan speeds, resulting in increased drag and design trade-offs. LINERFUN tackles the challenge of designing novel ALs that provide the necessary noise attenuation with reduced size without compromising aerodynamic efficiency. This complex task demands innovative solutions and a deep understanding of AL physics. LINERFUN aims to develop a physics-improved TDIBC (piTDIBC) model using scale-resolving simulations to predict sound propagation in turbulent flows within lined ducts. The piTDIBC model addresses the limitations of existing impedance models, which often fail to capture the intricate interaction between acoustic and aerodynamic phenomena. Due to piTDIBC's efficiency, LINERFUN will drive innovation in AL studies in academia and industry, enabling the conceptualization of ALs that meet the aeroacoustic, aerodynamic, and geometric challenges of UHBR engines. The project fosters interdisciplinary collaboration between Politecnico di Torino, the University of Melbourne, and ONERA, ensuring knowledge transfer among partners. Developing a new AL prototype to address UHBR acoustic challenges could be a significant milestone for the aerospace industry, revolutionizing AL technology and offering advanced tools for designing quieter, more efficient engines. LINERFUN contributes to the broader goals of reducing environmental impact and promoting the sustainability of modern air travel.

Keywords: acoustic liner,computational aeroacoustics,computational fluid dynamics,time domain impedance boundary condition
Broadband MEMS-based InfraRed spectrometers: The core of a multipurpose spectral sensing photonic platform (BROMEDIR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Partnership: Photonics (co-programmed)
Countries involved: Cyprus,France,Austria,Poland,Belgium,Germany
Call: Advanced multi-sensing systems (Photonics Partnership) (RIA) (HORIZON-CL4-2022-DIGITAL-EMERGING-01, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 4999821.25
EU funding (EUR): 4999821.25
Participants: 11
Project status: SIGNED

There is a continuously increasing need for miniaturised sensors providing simultaneous access to multiple chemical and biochemical parameters sensing. Optical spectroscopy is the golden standard for the identification and quantitative measurement of several chemicals simultaneously, using a single device: a spectrometer. Challenge #1: Conventional FTIR spectrometers are bulky benchtop instruments. Regarding PTS for gas sensing, the proof-of-concept has only recently been validated at macroscopy scale. Considering field deployment of such spectrometers, the main challenges are related to the production cost, ruggedness & size of the instrument. Challenge #2: A key advantage of FTIR absorption spectroscopy is its broad spectral range in the MIR range, where fundamental molecular vibrational tones have large absorption cross section. However, while conventional benchtop FTIR spectrometers can operate up to 25000 nm or more, it is still a big challenge when considering miniature spectrometers to reach a wide spectral range coupled with high sensitivity. SIWARE recently developed an ultra-compact, MEMS-based, FTIR spectrometer. The commercial product, NeoSpectra, is operating in the Near-Infrared range up to 2500 nm. BROMEDIR will address the aforementioned challenges and make an important step towards meeting the related need, using Neospectra as a Spectroscopy Development Platform, targeting though the development of a radically new spectrometer with multiple extensions of its capabilities beyond the SotA. In parallel, a novel, miniaturised PTS spectrometer will be developed, taking advantage of the same silicon-MEMS technology platform that has been used for the development of the PIC used in Neospectra’s FTIR chip. In BROMEDIR, this new generation of miniature spectrometers will be used to develop sensing platforms, to be demonstrated in 3 application domains: a) sustainable farming, b) hydrogen supply chain quality monitoring and c) fuel quality control

Keywords: mems spectrometer,miniaturised spectrometer,ftir,photothermal spectroscopy,atr
Cease or Persist: A multivariate mechanistic account of effortful persistence (COPE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Is this worth my effort? Should I persist and push through or give up and move on? We are constantly confronted with this fundamental question. Persisting through effortful endeavors at all costs is often the key to success in modern society. Reduced or excessive persistence is a hallmark dysfunction in many neuropsychiatric disorders (anxiety, depression, OCD, apathy, etc.) with massive individual and societal cost. Despite the urgency to better understand this process, how exactly we decide to cease or persist, and which cognitive, neural and neurochemical systems support persistence, remains unclear. With COPE, I propose a novel neuro-computational theory of effortful persistence, able to predict decisions to Cease or Persist (COPE), and how they emerge from the dynamic multivariate optimization of costs and benefits across momentary and long-term time scales. I propose that persistence depends on how much reward or punishment we expect, how effective our efforts are, and how surprising and unstable the environment is. I will 1) establish and test a neuro-computational model able to simulate effortful persistence, and the neural and neurochemical systems involved in supporting it. 2) I will causally test the neural circuit involved in effortful persistence combining transcranial Focused Ultrasound stimulation with advanced neuroimaging protocols designed to capture activity in small brainstem and midbrain nuclei. 3) I will probe the contribution of 3 key neurochemicals – Dopamine, Noradrenaline, and Serotonin – and use the COPE model as a prediction tool of the impact of pharmacological manipulation on brain systems and behaviour. COPE integrates the algorithmic, neural and neurochemical levels of explanation in a unifying model of effortful persistence, laying the grounds for phenotyping of abnormal decision-making in psychiatric disorders and personalization of treatment selection.

Keywords: effort,motivation,computational modeling,noradrenaline,serotonin,dopamine,fmri
Lightweight, Cost-effective Composite and Green Bipropellant System for Space Transportation Applications (GREENLAM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-12-31
Duration (months): 30.0
Total project cost (EUR): 254330.4
EU funding (EUR): 254330.4
Participants: 2
Project status: TERMINATED

Engineering novel materials and their design optimization using simulation-based tools enable the development of lightweight and sturdy thrusters. In Europe, the development of high-temperature-resistant structural materials for space transportation has gained momentum over the years. This has led to the increased usage of ceramic matrix composite over conventional metal alloys in aerospace applications. Most of the reported works focus on manufacturing cost-effective and lightweight composites, whereas the thermally stable nature of composites has not been fully explored. The Green Charter and European Green Deal promote low-emission forms of transport and emphasize developing sustainable and renewable forms of energy. The adoption of green fuels offers advantages in terms of total life cycle cost reduction, contributing to cheaper space transportation, and environmental impact reduction. Contemporary research innovations have expanded the development of "green propellants" for spacecraft in diverse space applications on a global level, primarily for eco-innovation and safety considerations. Studies with ammonium dinitramide, hydrazinium nitroformate with methanol, and ethanol-water are still in the nascent phase whereas H2O2 is delivering state-of-the-art performance to replace conventional hydrazine. This project aims to explore the possibility of developing a 1-100N class thruster made of thermally stable composite (carbon-ceramic) and green bipropellant (H2O2-Kerosene) system for the upper stage to reduce the overall weight, life cycle cost, and environmental impacts without compromising on the performance parameters. This will be researched through a comprehensive blend of multi-physics-based numerical modeling and analysis to generate a highly reliable design and a scale-specific experimental characterization and test rig to yield propellant formulation data corresponding to the state-of-the-art. The proposal will produce high societal, scientific, and economic impacts.

Keywords: nanofiber green propellant h2o2 high test peroxide composites eco innovation sustainable design