Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding the role of microglia in neurodevelopmental disorders (Micro_Syn)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Greece
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 181423.68
EU funding (EUR): 181423.68
Participants: 1
Project status: SIGNED

Neurodevelopmental disorders like autism (ASD) and Fragile X syndrome (FXS) are associated with changes in microglia function and synaptic pruning. No approved or effective therapies exist for FXS/ASD. Novel therapies are needed that target microglia, distinct from conventional drugs targeting neurons. Research on synaptic pruning mediated by microglia is scarce, and the role of microglia in FXS/ASD has been overlooked. Previous studies, including my own work and studies from the host laboratory, however, advanced approaches for analysis of microglia-synapse interactions and demonstrated that the abnormal pruning may be associated with the Integrated Stress Response (ISR) pathway since the elevated phosphorylation of eIF2α is linked to neuroinflammatory disorders characterized by excessive synapse loss. Thus, impaired microglial eIF2α phosphorylation may decrease synaptic pruning, highlighting eIF2α as an attractive target for restoring synaptic pruning in FXS/ASD. My project aims to uncover microglia's contribution to FXS/ASD pathophysiology. First, I will address how the FXS/ASD state affects synaptic pruning by microglia, microglial morphology, and function. Second, I will explore the role of microglia and FAM69, a novel kinase mediating eIF2α phosphorylation, in impaired synaptic pruning at the molecular and cellular levels. Genetically engineered mice and human brain organoids will facilitate visualization and targeting of microglia-synapse interaction. To assess changes in synaptic pruning, I will use viral vector-assisted silencing and overexpression of microglial FAM69, validating their impact on synaptic pruning by vital two-photon microscopy. Finally, I will evaluate whether these interventions can alleviate autism-like behavior. With this integrative approach, I aim to uncover novel molecular pathways mediating the synaptic pruning by microglia and to identify new targets for the treatment of FXS/ASD.

Keywords: autism spectrum syndrome,asd,microglia,synaptic pruning,eif2,fam69,integrated stress response,isr
Development and validation of Direct-Fed Microbials for farm animals to improve animal growth and better nourish the planet (Aviwell)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-12-01
End date: 2025-11-30
Duration (months): 36.0
Total project cost (EUR): 8225327.5
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

In 2021, the worldwide population was approximately 8B, and it is expected to grow at >1% annually. Over the past 70 years, the agriculture industry has made significant efforts to increase livestock production and improve food security, but the results are neither sustainable nor sufficient for current food needs. Aviwell has developed innovative Direct Fed Microbials (DFM) with the ability to control livestock body weight and energy metabolism, targeting specific phenotypes with greater efficiency and efficacy. These DFMs are diverse, native, natural and are only fed as a single dose in the early life of the animal. Also, Aviwell has created a new-concept hybrid AI-based Discovery Platform that quickly and efficiently identifies powerful multi-strain bacterial consortia networks; constantly improving and extending our DFM product portfolio. Aviwell needs the EIC funds for the completion and the optimization of both the platform and DFM products, and its market-approval and entry.

Keywords: biotechnology
Understanding the evolution of continuous genomes (HaplotypeStructure)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2499851.0
EU funding (EUR): 2499851.0
Participants: 1
Project status: SIGNED

An organism's phenotype depends on a multitude of genetic variants, spread over a linear genome. This is widely understood, and yet in practice, has hardly been incorporated into population genetic analysis. Recent developments in theory, computation, and sequencing technology now make it possible to obtain and analyse whole haploid genomes on a large scale. This proposal is to develop and apply a theoretical analysis of genetic variation that is spread over continuous linear genomes. Theory and methods will be developed in close interaction with empirical data from artificial selection experiments and from an intensely studied hybrid zone in Antirrhinum; for both, we have a known pedigree, and phased whole-genome sequence. Population structure will be analysed by following blocks of genome through pedigrees, and across two-dimensional landscapes. Selection on discrete loci will be analysed by finding its effect on surrounding haplotypes, by analysing how favoured alleles become disentangled from heterogeneous backgrounds, and by seeing how haplotype blocks flow past selected clines. The contribution of variants that are spread across the genome to GWA, to selection response, and to hybrid zones will be modelled, and the overall effect of inherited fitness variance on haplotype structure will be determined. This work will establish a new framework for population genomics that goes beyond the current focus on individual loci. It will help bridge the distinct communities within genomics, quantitative genetics, and population genetics, which currently tackle these problems largely in isolation. The project will develop better tools for inferring selection and population structure from DNA sequence data, and more fundamentally, will give us a deeper understanding of how the abundant variation that is carried on linear genomes is shaped by evolution.

Keywords: population genomics population structure genome evolution infinitesimal model quantitative genetics
REGIME: Transmission Regimes of Climate-Sensitive Infectious Diseases in Latin America (REGIME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Brazil
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 3
Project status: SIGNED

Extreme climatic events, environmental degradation and socio-economic inequalities exacerbate the risk of mosquito-borne disease (MBD) epidemics and modulate the transmission regimes of these diseases. Most MBDs can coexist and share patterns, which are sensitive to biodiversity loss, land use and land cover change, as well as climate, and socioeconomic and demographic factors. Determining the spatial and temporal scales at which these complex factors interact and modulate disease transmission can help to target effective control and prevention strategies. This research goes beyond the state-of-the-art by developing an innovative modelling tool called REGIME to assess the relative impact of multiple determinants on MBD emergence, spread and co-circulation in Latin America. Models will be formulated using data for Brazil over the past 20 years at the municipality level (5,570 municipalities). Multivariate cluster analysis will be performed to propose a transmission regime classification (e.g. endemic, epidemic, episodic) using disease case time series for each municipality each year to identify temporal changes in the transmission regimes. A model based on the transmission regimes will be designed to disentangle the role of different disease drivers, using multi-source data and random effects, which account for additional layers of uncertainty and help identify unknown spatial patterns, inter-annual signatures and similarities or differences between the drivers for each disease. The knowledge gained from Brazil will be applicable in a broader context in Latin America, by validating the model framework in the context of disease risk scenarios shared by those countries. REGIME will facilitate the generation of actionable knowledge to inform local risk mapping and build robust early warning and response systems to build resilience in low-resource settings.

Keywords: mosquito borne disease,extreme climatic events,environmental degradation,socioeconomic factors,multivariate analysis,disease transmission regime
Regional Economy / Travel Expectations (RE-TE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-09-01
End date: 2025-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The assessment of the economic health of economies around the world has historically been based on reports prepared by multiple public and private institutions – from banks to governments. These describe how an economy has evolved in the past, but are lagging and low-resolution pictures of fast evolving systems, and are therefore hill-suited for guiding real decision-making processes under uncertainty. The solution could come from air transport and its demand, as these can provide real-time indicators of the intentions of citizens and companies to travel several months in the future; but are also linked to, and therefore describe, the evolution of the economy in general. By relying on large-scale data sets covering several aspects of air transport, from operational plans to price evolution, this project proposes exploring the societal and commercial value of macro-economic indicators extracted from air transport. From a technical perspective, this will be achieved by deploying an IT infrastructure to support the creation and distribution of reports based on such indicators and their respective evolution. Most importantly, the value of these reports will be tested in three use cases targeting the general public, a large regional government, and a SME. We will thus explore the commercial value of such reports and their suitability for supporting a future business, while also providing a freely given added value for society at large.
Paleodietary analyses of the first Andean cities: high-resolution assessment to macronutrients using a multiproxy approach. (PACHAMAMA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

Paleodietary analyses of the first Andean cities: high-resolution assessment to macronutrients using a multiproxy approach. The socio-ecological circumstances that underpinned the rise of the earliest urban centers in the Americas are some of the most intriguing and unclear aspects of New World archaeology. In particular, the emergence of Andean cities 5000 years ago has been the subject of contentious debates. On one hand, the Maritime Foundations of Andean Civilization have challenged the conventional assumption that agriculture was a pre-condition for early city development, and on the other, recent archaeological investigations have reenergized these debates by demonstrating that plant management and agriculture were developed in the region before the rise of complex societies and urban centers. Uncertainties remain regarding the proportional contributions of plants, fish and terrestrial animals to individual diet, and their potential roles in sustaining early sedentary and stratified urban populations engaged in monumental architecture. PACHAMAMA will employ a suite of molecular techniques to unlock the relationship between diet and processes of social complexity among early urban groups in coastal Peru. Using a multiproxy approach that integrates stable isotopes of bone collagen (bulk and single amino acids), Bayesian mixing models, and palaeoproteomic analyses of dental calculus, the fellow will address the role of marine resources and plant production systems in Formative period (3000 - 1 BC) populations on the North-Central coast of the Central Andes, a region known as "the crucible of Andean Civilization." This novel integrative approach will advance the state-of-the-art on social complexity and urban development in hyper-arid regions of the ancient world.

Keywords: bioarchaeology,paleodiet,history of agriculture,trajectories to civilization,andean civilization,formative period,history of urbanization,americas first cities
ENTEROVIRUS-LINKED TYPE 1 DIABETES EXPOSED -MECHANISMS AND PREVENTION (ENT1DEP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Finland,Norway,Sweden,France,Germany,Estonia,Australia
Call: Relationship between infections and non-communicable diseases (HORIZON-HLTH-2023-DISEASE-03, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 7144790.0
EU funding (EUR): 7144790.0
Participants: 14
Project status: SIGNED

ENT1DEP aims to define causal links between infections and NCDs by focusing on enterovirus (EV) infections and type 1 diabetes (T1D), a robust association without proof of causality. Causality is addressed by a multidisciplinary, multi-layer approach, using in-vitro and in-vivo models, unique human samples, and artificial intelligence to identify mechanisms and related biomarkers, asking 3 key questions: 1. Why are only insulin-producing β-cells destroyed by EVs? Weak β-cell antiviral responses and high expression of EV entry receptors may favour EV persistence. This hypothesis is addressed using human cell models (stem-cell-derived β/α-cells, organoids, their genetic modifications, anti-EV T-cells) and pancreas tissues from T1D patients. 2. Why do only some individuals develop T1D after EV infection? Weak EV immunity may predispose to virus spreading to pancreas, persistence and local inflammation, triggering autoimmunity. This hypothesis is addressed by analysing adaptive and innate immune responses to EVs, correlating these with gene polymorphisms and EV persistence in children followed from birth and who developed T1D. 3. How can EV-associated T1D risk be attenuated? By using vaccines inducing protective immunity and antiviral drugs eradicating persistent infection. This hypothesis is addressed by examining samples from pioneering EV vaccine and T1D antiviral trials to develop biomarkers of vaccine- vs infection-induced immunity as surrogates of vaccine efficacy; by studying whether vaccine-induced antibodies prevent EV-induced diabetes in mice; by correlating antiviral treatment with EV clearance and immunity to identify biomarkers for EV eradication and patient selection. The final goal is to identify individuals at risk for EV-induced T1D as targets for early interventions. These outcomes may also facilitate progress in other NCDs extending impact. This new knowledge is disseminated among stakeholders to facilitate optimal NCD prevention and treatment.

Keywords: non communicable diseases,type 1 diabetes,enteroviruses,immune response,causality,vaccines,antiviral drugs,artificial intelligence,prevention,prediction
First-in-class anti-PVR mAb NTX1088 - a novel oncology drug that unlocks the power of human immune system and revolutionizes cancer care (NTX1088)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-08-01
End date: 2028-01-31
Duration (months): 42.0
Total project cost (EUR): 3571427.0
EU funding (EUR): 2499998.9
Participants: 1
Project status: SIGNED

Nectin Therapeutics (NectinTx) is a venture-backed company with a top-notch team focused on innovative therapeutic options for cancer patients. To address the limitations of available therapies, the company has developed a diverse pipeline of antibodies that overcome immune inhibitory pathways deployed by the tumours. NTX1088 is a monoclonal antibody that binds human poliovirus receptor (PVR) and activates patient’s immune system to fight cancer through a triple mechanism of action never demonstrated before. A comprehensive preclinical dataset was generated to show the robust antitumor activity of NTX1088 in vitro and in vivo. Following IND approval and strong backing from key opinion leaders, Phase I clinical trial has commenced, aimed to enrol patients with solid tumours. The project will accelerate the clinical development of NTX1088 towards a novel therapy on the €80 billion immune-oncology drug market, resulting in better outcomes for patients and reduced societal and economic burden associated with cancer.

Keywords: oncology,immunology,drugs
Smart Modular Wind Propulsion Solution for Shipping Decarbonisation (SmartWingSail)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Advanced Wing Systems Limited (AWS) is transforming maritime transport with scalable wind propulsion technology, addressing decarbonization in a sector responsible for 3% of global CO2 emissions. Our modular wing sail systems deliver up to 30% annual fuel savings per vessel, reducing CO2 emissions by 1,090–1,522 metric tons annually. Designed for retrofits and new builds, they align with the EU's Green Deal, Fit for 55, and the Sustainable and Smart Mobility Strategy, while supporting initiatives such as Zero-Emission Waterborne Transport and the Renewable and Low-Carbon Fuels Value Chain. AWS is advancing its Technology Readiness Levels (TRL), with Model 1 targeting TRL 8 by Q4 2025 and Model 2 by Q3 2026, achieving TRL 9 and full commercialization by 2027. Within five years, we aim to retrofit 400 vessels with over 1,200 sails, saving 485 kilotonnes of CO2 and generating €200M in annual recurring revenue. Backed by a €2.5M EIC Accelerator grant, our €8.5M funding round will drive scaling efforts, create over 50 direct jobs, and contribute significantly to the EU economy by 2030. Our disruptive technology addresses key barriers in traditional Wind-Assisted Propulsion Systems (WAPS), offering low-cost installations (€30,000–50,000 per sail), AI-driven automation, and rapid scalability. By ensuring compliance with EU ETS and FuelEU Maritime regulations and leveraging a cost-efficient leasing model, we make decarbonization accessible to a wider market. Strategic partnerships with Lomar Shipping, Navim Group, and Sustainable Sailing Ltd position AWS at the heart of the EU industrial ecosystem, advancing innovation, maritime decarbonization, and economic growth.

Keywords: maritime decarbonization,wind propulsion,modular sails,fuel savings,eu ets compliance,renewable energy,scalable retrofits,ai driven automation,sustainable shipping,green technology
Satellite Processing By Artificial Intelligence - Enabling Satellite Analytics (EARTHPULSE)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Spain
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

BUSINESS NEED. Climate change leads to infrastructure disruption, food insecurity and global losses and hence, does directly affect safety and security of people. Nowadays, when an event occurs emergency protocols are activated, and damages are evaluated in the following days. There is a need of having vulnerability assessment information, before the event occurs to know where the most vulnerable area, asset or population is. Knowing the most vulnerable point and its dynamic evolution (where the impact will be worst) is a key information to generate an adaptative answer to climate extreme events and minimize socio economic damages. However, current impact analysis methods are semi-automated, limiting the speed, coverage and number of analyses that can be done. Our solution, interoperable, fast to deploy and easy to use, is based in the analysis of different data sources such as Copernicus (Satellite data), Meteo patterns and OpenData. MARKET OPPORTUNITY. During the last decade thousands of satellites have been put in orbit creating the new space economy. The total amount of investment done just in Copernicus Satellites amounts to 8,2 Billion. In addition, according to Space Capital the total equity investment over the last decade in the space economy was €177.7 billion. However, the penetration over different industrial markets is very low , putting at risk the Return of Investment (ROI). EARTHPULSE GOAL. Artificial Intelligence (AI) is the transformational technique of our era. Satellite data, and in particular, Earth Observation (EO), will greatly benefit, as other areas, from its application by lowering the cost of adoption and accelerating market uptake. Our company goal is to accelerate the market uptake of EO data with AI. At EarthPulse we are working hard on overcoming these barriers with the objective to leverage the full potential of AI4EO to make satellite analytics accessible to anyone (experts and non-expert users) through our Software SPAI.

Keywords: artificial intelligence,earth observation