Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Tropical Micro-Archaeology: An interdisciplinary project aiming to study site formation processes in tropical environment related to hunter-gatherers' use of space (TROPICMICROARCH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

TropicMicroArch aims to study how hunter-gatherers' ways of living are reflected in their use of space and how it affects the depositional processes of microscopic materials in tropical forests. Although hunter-gatherers' use of space has previously been studied through Ethnoarchaeology, this project proposes to study it from a new microscopic perspective with special attention given to post depositional processes. In comparison to arid, semi-arid and temperate environments, site formation processes at tropical forest open air sites have not yet been studied in detail. This project will develop methods of sediments sampling and mapping and methods of laboratories analyses of microscopic remains which will aid the archaeological research to analyze the use of space among prehistoric hunter-gatherers and to understand and observe formation processes in tropical sites. This will be achieved by conducting ethnographic and geoarchaeological fieldwork, geochemical analyses and spatial mapping. Fieldwork will centers on living and abandon settlements of a contemporary hunter-gatherer community in the tropic forests of South India. Research will take place in the McDonald Institute for Archaeological Research in the University of Cambridge, where the integration of humanities, social sciences and exact sciences is possible. Due to its multidisciplinary properties, this study will involve several host scientists and mentors from the Department of Anthropology and Archaeology at Cambridge University, in addition to collaboration with researchers from other departments and institutes from Europe and Asia. The fellow will benefit from the interplay and integration of scientific practice and theory in Cambridge University. He will gain invaluable training and experience as a member of the McDonald Institute and the McBurney Laboratory for Geoarchaeology, where many studies related to hunter-gatherers and tropical environments are currently being held.

Keywords: geoarchaeology,tropical forests,hunter-gatherers,use of space,site formation processes
Mobile elements: shuffling the regulome in development and disease. (EVOLINE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2015-02-02
End date: 2019-02-01
Duration (months): 36.0
Total project cost (EUR): 265317.3
EU funding (EUR): 265317.3
Participants: 1
Project status: CLOSED

The present structure of the human genome is largely a result of the activity of Transposable Elements (TEs) or jumping genes. Indeed, they have constantly provided genomic variability over evolution, resulting in the generation of new genes and new regulatory circuits among others, and they are still doing it now, mainly leaded by the activity of few classes of TEs as LINE-1 retrotransposons. LINE-1s are the only autonomous active TEs currently mobile in the human genome, and its activity has been responsible for the generation of at least half of it. Strictly, LINE-1 elements are molecular parasites as they solely replicate in our genome with evident genomic instability effects. However, the recently described activity in healthy human brain, where non-heritable (and thus non-selfish) insertions would provide some sort of genomic plasticity, stokes the discussion about their parasitic (instability) versus symbiotic character (variability, plasticity). In addition, it has been recently reported LINE-1s mobilisation in all human tumours examined to date. Whether their activity participates in the generation/promotion of cancer remains unknown. It is established that many fixed TEs evolved as part of the regulome in a myriad of ways, like for instance becoming gene distal enhancers. However, new somatic TE insertions might impact gene expression/regulation in a mosaic manner, editing the information stored in the somatic genome in some way. In EVOLINE, I propose to conduct real time evolution experiments to infer the phenotypic consequences induced by new somatic TE insertions. Specifically, EVOLINE aims to reveal the role of TEs in the edition of the somatic genome and its effect on neuronal development and cancer. As LINE-1s represent a third of our genome and because of their ongoing activity, deciphering the impact that new somatic TE insertions exert in the human genome will help us to understand their role in genome dynamics and their impact on human diseases.

Keywords: line-1,retrotransposons,genome,next generation sequencing,gene regulation,somatic retrotransposition,enhancer,chromatin conformation capture
Transport Jars and Commodity Exchange in the Late Bronze Age Argolid: Tiryns and Midea (COMEX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

This project will provide major insights into commodity exchange and maritime links, in the Bronze Age Aegean world and Eastern Mediterranean, through the detailed analysis and publication of Transport Jars of LHIIIA-LHIIIC date in the Argolid, Greece. Building on important new evidence from the major citadels of Tiryns and Midea, it will use thin section petrography and chemical analysis to ascribe provenance to transport jars of the late 14th to 12th centuries BCE. Recent work on transport amphorae and notably Transport Stirrup Jars (TSJs) has demonstrated the great potential of integrated petrographic and chemical analysis to answer questions on the provenance of ceramics and their contents (e.g. Haskell et al. 2011; Day et al. 2011), the latter work concentrating on Crete. Now, transport jars including TSJs, Canaanite amphorae, Cypriote and Attic, will be analysed and compared to the extensive, comparative datasets held by the Sheffield – NCSR ‘Demokritos’ research team, which covers not only the Aegean, but relevant material from much of the Central and Eastern Mediterranean. This important, diachronic ceramic evidence will be used to trace contact between the Argolid, Crete, Cyprus and the Levant both during the life of the Mycenaean Palaces and immediately after their demise. Tiryns and Midea provide an unrivalled resource for such work and it will produce the first fabric-based work on major deposits from these sites. In a dynamic partnership with Higher Education and public institutions, Dr Marta Tenconi, the proposed IEF, will illuminate commodity exchange in the Argolid, the core area of the Mycenaean world. The research will lead to major academic publications, dissemination to the public by national press and a museum outreach programme.

Keywords: ceramics,exchange,bronze age,aegean,petrography,inaa,transport jars,mycenaean,argolid,tiryns,midea
Remote Estimating Vegetation Health (VEGHEALTH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-03-01
End date: 2016-02-29
Duration (months): 24.0
Total project cost (EUR): 256148.4
EU funding (EUR): 256148.4
Participants: 1
Project status: CLOSED

With the current trends of climate change associated with human-induced changes in the amount and composition of atmospheric greenhouse gases, never before has it been so important to understand the spatio-temporal patterns of carbon sequestration through vegetation productivity. Quantifying pigment content, which is a main factor influencing the amount of radiation absorbed by photosynthetically active vegetation and a very direct expression of the photosynthetic apparatus of the plant kingdom, strongly relating to productivity, is one of the main scientific component of vegetation health monitoring. Developing methods to quantify pigment content and composition from remotely sensed data would clearly provide a capability that could advance understanding of photosynthetic processes and insight into detection and monitoring of vegetation condition - health and vigor. Monitoring plant physiological status via measuring reflectance offers a number of distinct advantages over traditional destructive approaches. The most important are simplicity, sensitivity, reliability a high throughput and global coverage. Overall goal of the project is to develop a prototype "Satellite-based Vegetation Pigment Product" that will accurately estimate pigment content and composition in vegetation and will be easy to implement. Specifically, we will (a) develop non-destructive techniques for estimating pigment contents at the leaf level, for calibration and validation of satellite-based retrievals; (b) devise remote sensing techniques for estimating the total pigment content and composition at the canopy level; and (c) apply developed techniques to the satellite data and assess uncertainties of the pigment content estimation. The European Space Agency is developing new missions called Sentinels specifically for the operational needs of the “Global Monitoring for Environment and Security” program. Models developed recently in my lab, which are able accurate determination of main vegetat

Keywords: vegetation health,productivity,pigments,carbon sequestration,satellites,monitoring,sentinel.
PROTECTED AREAS AND THE EXPANSION OF NEOLIBERAL CAPITALISM IN EUROPE (PAENCE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 2
Project status: CLOSED

Central to the constitution of current ecological crises are modernist environmental views that separate nature from society, culture and civilisation and which make possible large-scale exploitation and despoliation of natural resources. In recent decades, the critical study of conservation conflicts have contended that, despite promoting new environmental attitudes, most conservation initiatives have failed to query the nature-society separation that underlies ecologically depredatory initiatives. But nature conservation is experiencing profound changes, which challenge our current knowledge of the tensions surrounding the relationship between conservation policies and Western ideas of nature and society in binary opposition. The growing links between capitalism and conservation and the current economic crisis are extending the faith in market solutions to environmental problems and creating new spaces for global capital expansion. This research project seeks to critically analyse the ideas of nature that are encouraging new neoliberal trends in Protected Areas, facilitating their conversion into new spaces for global capital expansion, and the intentionality, situated interests and individual and collective agencies behind them. This research will focus on the multi-level network of individuals and institutions that supports an ongoing phenomenon of territorial reintegration and land-use reorganisation in two Protected Areas in the Region of Andalusia (Spain) with the aim to promote the growth of a service economy, replacing customary farming and fishing practices whose reliance on subsidies makes them clearly deficient within a globalised economy. I will identify these actors and institutions and trace their worldviews, practices and role in processes of decision-making with the intention to unveil how Protected Areas have become an instrument to incorporate marginal regions and livelihoods to global capitalism and the role ideas of nature play in this process

Keywords: protected areas,conservation conflicts,nature-culture,neoliberal conservation supporters,neoliberal environmentality,europe,andalusia
Crosstalk between microRNAs and epigenetics in melanocyte differentiation: A new approach to unravel the complexity of melanoma progression and metastasis. (EPIMIRMEL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-04-23
End date: 2017-07-01
Duration (months): 36.0
Total project cost (EUR): 352176.3
EU funding (EUR): 352176.3
Participants: 1
Project status: CLOSED

Melanoma is the most aggressive form of skin cancer and one of the most invasive tumor types. Melanoma incidence keeps increasing worldwide and the therapeutic choices are limited. The lack of treatments with durable responses may be due, at least in part, to an incomplete understanding of the molecular mechanisms that regulate tumor initiation and/or progression to metastasis. Therefore, there is an urgent need to find new strategies to expand our knowledge of melanomagenesis. We propose a new approach to unravel the complexity of melanoma: To use a cellular differentiation model to decipher the role of epigenetic regulation during melanocyte differentiation and its contribution to melanoma progression. Melanoma cells often express developmental genes, display multi-differentiation potential, and seem to recapitulate the migratory nature of neural crest stem cells from which melanocytes arise. We reasoned that studying a model of differentiation of melanocytes from neural crest stem cells could be useful to identify the mechanisms that modulate melanoma stem-like properties, probably among the most significant contributing features to the tumor aggressiveness. The plasticity and reversibility of the epigenetic mechanisms make them ideal orchestrators of these dynamic processes. Then, we hypothesize that epigenetically controlled miRNAs could be involved in normal differentiation and in tumorigenesis when altered. Thus, aberrant epigenetic modifications could be responsible for reactivation (or retention) of stem-like properties in melanoma cells. The identification of epigenetically regulated miRNAs involved in melanoma progression will be useful not only as prognosis biomarkers in order to stratify patients for more rigorous follow-up and aggressive therapy, but also by their potential as therapeutic targets considering the reversibility of epigenetic changes.

Keywords: melanoma,mirna,epigenetics,melanocyte differentiation,stem cells,metastasis
Improving Dyslexic Children's Reading Abilities: the Role of Action Video Games and Hypermedia Texts (LCLD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-10-01
End date: 2017-03-31
Duration (months): 30.0
Total project cost (EUR): 226481.7
EU funding (EUR): 226481.7
Participants: 1
Project status: CLOSED

The main aim of this project is to identify practices for improving dyslexic children’s reading abilities, starting from some very recent stimulating findings in the field (Facoetti A., Franceschini S., Molteni M., Gori S., Ruffino M., Viola S., 2013): in March 2013, the journal 'Current Biology' has published the results of a research carried out at the University of Padua (Italy) in which Italian dyslexic children’s development of reading skills has been correlated to attention training: following research works analysing the role of Action Video Games for training attention published on very influential journals in the last ten years, the dyslexic children have been asked to play Action Video Games for 12 hours with no other orthographic or phonological training. At the end of the Video Games sessions the researchers have found out that reading speed has improved considerably, without any cost in accuracy. In particular, it has improved more than what it generally improves after one year of spontaneous reading development. The present proposal aims at expanding the Italian data by evaluating the efficacy of this kind of training with English speaking children (in the otgoing phase) and with another sample of Italian children (in the return pase). In both Countries (Australia and Italy) three groups of children will be selected: a group will be trained through the same Action Video Games used in the Padua research; a group will be trained through a multimodal hypermedia platform; a third group of children will continue being treated with traditional methods. This will permit a deeper investigation of attention training efficacy for improving reading abilities and, at the same time, a cross-linguistic analysis to analyse the role of the language spoken by children. This research may also help lay the basis for tcreating Adaptive Training Platforms where children’s reading abilities can be improved through stimulating and user-friendly digital environments.

Keywords: dyslexia-reading abilities-attention training-action video game-hypermedia multimodal texts
Anticancer nanoparticles from amphiphilic macromolecular produgs (AMPHIDRUGS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-05-01
End date: 2016-04-30
Duration (months): 24.0
Total project cost (EUR): 202405.8
EU funding (EUR): 202405.8
Participants: 1
Project status: CLOSED

Among the numerous classes of drug delivery systems, drug-loaded polymer nanoparticles have attracted much attention. Although this approach has led to numerous encouraging results and proofs of concept in vitro, important limitations still remain, which may explain the lower number of successful in vivo studies and the limited number of marketed nanomedicines. In this view, the current project aims at developing an innovative and versatile nanoparticulate platform to prepare well-defined amphiphilic polymer-drug “prodrug” nanoassemblies by means of controlled/living radical polymerization (CLRP) techniques, such as nitroxide-mediated polymerization (NMP), atom transfer radical polymerization (ATRP), or reversible addition-fragmentation chain transfer (RAFT). The new, facile and general strategy we propose relies on the controlled growth of biorelevant polymers (hydrophobic or hydrophilic) from functionalized drugs of the opposite solubility under CLRP conditions. This will result in well-defined amphiphilic species, bearing one drug molecule at the extremity of each polymer chain, able to self-assemble into nanoassemblies of various morphologies, exhibiting high drug payloads and thus high biological activities. This new methodology tends to be: (i) universal as it is virtually applicable to multiple drugs and consequently to multiple pathologies and (ii) versatile as various polymer prodrugs can be produced with high degree of control and flexibility over their structures (e.g., nature of the drug/polymer couple, nature of the linker, polymer chain length, etc.). This will be illustrated by the synthesis of a broad range of polymer prodrugs from a wide selection of drugs having demonstrated activities against cancer. Comprehensive characterization of the resulting nanoassemblies will be performed as well as their pharmacological evaluation in vitro (cell culture) and in vivo on relevant models, according to standardized protocols.

Keywords: polymer,polymerization,nanoparticles,prodrug,cancer
Targeting Glioblastoma Signalling (GBMTARGET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-03-01
End date: 2016-02-29
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

This project will establish a computational strategy which exploits polypharmacology to identify drug targets in biological systems implicated in cancer. The value of our polyphamacology platform will be tested by application to glioblastoma multiforme, a deadly brain cancer. The aim will be to identify multiple targets in protein networks linked to glioblastoma to thereby enable repositioning of drugs against that cancer. The novelty of the work will lie in its use of protein domain structure data to link known and putative drug compounds to biological networks. The project is proposed as an interdisciplinar and intersectoral research: (i) It will be developed on the basis of the domain structure resources and expertise in the host group of Prof. Orengo at University College London (UCL), and the compound-target libraries and drug discovery expertise within the pharmaceutical company GlaxoSmithKline, which will be a seconded host institution; (ii) it will benefit from the expertise in protein-ligand interactions developed in the group of Prof. Janet Thornton and the group of Prof. John Overington at the European Bioinformatics Institute; (iii) the experimental testing of putative drug compounds will be undertaken in collaboration with the group of Dr Matilda Katan-Muller at UCL and the group of Prof David Selwood at UCL.

Keywords: structural biology,bioinformatics,computational biology,systems biology,cancer and its biological basis,pharmacology,cell signalling,networks