Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
COllaborative Platform for trAnsmedia storytelling and cross channel distribution of EUROPEan sport events (COPA EUROPE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Israel,Germany,Germany,Spain,Cyprus,Greece,Greece,France
Call: Next Generation Media (H2020-ICT-2020-1, 2020)
Start date: 2020-11-01
End date: 2023-10-31
Duration (months): 36.0
Total project cost (EUR): 6207098.75
EU funding (EUR): 4904355.88
Participants: 10
Project status: SIGNED

COPA EUROPE aims to address the exploding demand for non-linear sports consumption (live and eSports) by leveraging OTT and combining it with new set of media technologies that will democratise the consumer experience, enable cost-sensitive live video from anywhere, and personalize the distribution to change the experience of each viewer individually. COPA EUROPE will deliver a cloud-based infrastructure for harvesting, accommodating, transmitting and distributing digital media with regard to sport and competitive events, including the infrastructure needed to allow content creators and producers of live coverage to react to live outcomes, via innovative workflows. COPA EUROPE vision is founded on four main pillars, ripe with potential for future media industry innovation: Media AI, which implements a secure recommender system fuelled by FL, specifically tailored to support the launching of personalized OTT channels, incorporating a variety of data (video, audio, statistical data etc.) harmoniously blended with commercial offerings in order to provide an enriched experience, to promote the personalisation of the provided services. Transmedia Storytelling, which aims to aid both connected subscribers and media professionals in indexing, searching, navigating, synchronizing and editing compelling productions from heterogeneous media sources and a variety of social media channels. Semi professional cloud-based live content workflow, from live video contribution and transmission from anywhere, through basic tools for semi-professional content production leveraging on context-tailored transcoding and bonding transmission using multiple 5G links, and/or 4G together, to ensure reliability, video continuity, high resolution and user experience. Blockchain, which provides support for P2P network infrastructure necessary to deliver an efficient smart contract transaction ecosystem, and subsequently deliver a decentralized live stream to individual paying subscribers.

Keywords: over the top ott streaming,sports and esports media,live video,consumer experience,transmedia storytelling,blockchain
Selecting genetic lesions with essential function for patients' leukaemia in vivo as targets for precision medicine (LeukaemiaTargeted)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-08-01
End date: 2021-07-31
Duration (months): 60.0
Total project cost (EUR): 1945818.0
EU funding (EUR): 1675510.0
Participants: 2
Project status: CLOSED

In Europe, around two million individuals die from cancer each year. Cancer is a genetic disease and each patient's tumour contains several genetic lesions which are identified by next generation sequencing (NGS) and influence patient's outcome. A global current challenge lies in translating NGS data into benefit of cancer patients. As attractive novel therapeutic concept, precision medicine addresses genetic lesions using targeted therapies. A large number of targeted drugs and compounds exist and are currently developed such as kinase inhibitors; unfortunately, numerous clinical trials on targeted therapies failed. In order to better exploit NGS data, it is important to discriminate between genetic lesions that are required and maintain patients' tumours in vivo and others that do not – an impossible mission so far. My proposal aims at solving this key question. Using acute leukaemia as model tumour disease, we propagate primary tumour cells from patients in immuno-deficient mice. We recently pioneered a worldwide unique technique which allows the distinct genetic manipulation of individual patients' tumour cells while they grow in vivo. We will molecularly target tumour-specific genetic lesions one by one; if tumour load is reduced, the lesion fulfils an essential function; essential lesions represent attractive therapeutic targets. Using our cutting edge technology, we will identify genetic lesions with essential, tumour-relevant function (i) in established tumour disease and (ii) in the clinically challenging situations of minimal residual disease and relapse. Our approach implements a new paradigm for target selection in oncology. Our work introduces molecular target validation as important step into the value chain of precision medicine which will tailor drug development by industry and academia. Our approach will improve patient care and the success rate of clinical trials for the benefit of patients suffering acute leukaemia and putatively other cancers.

Keywords: target validation,in vivo function of genomic mutations,preclinical in vivo models,acute leukaemia,primary tumour cells of individual patients,patient derived xenografts,genetic engineering
Light-Atom Interactions in Nanophotonic Structures (LANTERN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-01
End date: 2019-03-31
Duration (months): 36.0
Total project cost (EUR): 257191.2
EU funding (EUR): 257191.2
Participants: 2
Project status: CLOSED

In recent years, tremendous progress has been made to interface cold atoms with nano-photonic systems, with the motivation of scaling down and transferring ideas from macroscopic platforms, such as cavity QED in Fabry-Perot cavities. However, little attention has been devoted to identifying completely new paradigms for light-matter interactions, which take full advantage of the ability to control the dimensionality and dispersion of light in nanoscale optical structures. Within this context, LANTERN makes an ambitious attempt to theoretically propose new techniques to manipulate atom-photon interactions, to design realistic photonic crystal structures that are simultaneously capable of trapping atoms and realizing the desired physical phenomena, and to help guide state-of-the-art experiments in the field. The fellow will show how such structures can be used to induce strong and tunable long-range interactions between atoms, and to realize strong optical nonlinearities at the single-photon level that do not depend on the saturation of an atom. These approaches are expected to overcome major bottlenecks faced by current experiments to use atoms in quantum information processing and quantum simulation. The multidisciplinary perspective of this action will advance the state of the art in quantum optics, nanophotonics and atomic physics, and will lead to fruitful synergies between theoretical and experimental groups. During the outgoing phase of the grant, Ana Asenjo will join the Quantum Optics group lead by Prof. Kimble at Caltech, in the USA. In the return phase, she will team up with the Theoretical Quantum-Nano Photonics group lead by Prof. Chang at ICFO, in Spain.

Keywords: quantum optics,nanophotonics,photonic crystals,cold atoms,cavity qed,nonlinear optics,quantum simulation
Combined Chemo- and Radiotherapies by Controlling the Surface Chemistry of Truncated Metal Organic Framework Nanoparticles (SCoTMOF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 1493777.0
EU funding (EUR): 1493777.0
Participants: 1
Project status: SIGNED

Cancers are the leading cause of death in the developed world, with populations facing a 30% chance of developing the disease by the age of 75. As part of a concerted effort to open up new treatments and improve patients’ experiences with existing ones, the concept of drug delivery – using non-toxic carriers to transport medicines directly to the location of disease – has emerged. Metal-organic frameworks (MOFs), porous materials comprised of organic linkers and metal joints, show considerable promise as drug delivery vectors due to their high storage capacities, amenability to functionalization and the ability to prepare entirely non-toxic nanoparticulate derivatives. This proposal will use the PI’s expertise in advanced MOF synthetic methods to facilitate dramatic technological breakthroughs through unprecedented control of MOF self-assembly and surface chemistry. Management of MOF surface chemistry will allow installation of stimuli responsive release mechanisms and offer control over the trapping and release of cargo within MOFs, ensuring drugs are released only at the site of disease in the body. Surface incorporation of sophisticated biotargeting units such as peptides and aptamers will facilitate selective uptake of the MOFs by diseased tissues only. Rapid clean microwave syntheses will allow metal radionuclides to be incorporated for PET imaging, offering a novel alternative to traditional chelates. Comprehensive in vitro and in vivo testing will ensure that this multidisciplinary streamlining of materials, supramolecular and medicinal chemistries with the biosciences will generate highly efficient theranostic devices, offering more efficient, targeted drug delivery to improve treatment efficiency, mitigate side effects and open up new therapeutic avenues such as siRNA delivery. The fundamental advances required to generate these novel materials will also impact across the many applications of MOFs, from molecular storage and separations to catalysis.
Motif repeats in intrinsically disordered regions of the clathrin mediated endocytosis pathway (MultiMotif)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany,France
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2025-03-31
Duration (months): 74.0
Total project cost (EUR): 1599809.0
EU funding (EUR): 1095590.31
Participants: 2
Project status: SIGNED

Linear motifs are short sequence stretches that occur in intrinsically disordered protein regions (IDRs) lacking stable secondary and tertiary structure, and mediate vital interactions within various biological systems. An exemplary system for the presence of IDRs and a high concentration of linear motifs is the clathrin mediated endocytosis machinery of the eukaryotic cell, where a complex interaction network of IDR-rich adaptor proteins enables both protein and lipid interactions. The molecular mechanism of such interactions, especially when multiple motifs act in concert, is however only poorly understood particularly since the dynamic and flexible nature of IDRs makes them a very difficult object to study. I aim to develop an integrative approach based on single molecule fluorescence and NMR spectroscopies to characterize the molecular principles of IDRs in clathrin mediated endocytosis. A systematic analysis of IDRs with different types of motifs and various interaction partners will not only shed light on the molecular functions of linear motifs within endocytosis, but also on how multiplicities of linear motifs may work in various biological processes in general. In vitro structural studies will be connected with single molecule imaging to relate molecular conformation with function within the cell.

Keywords: intrinsically disordered proteins
Does the temporal cortex make humans special? What comparing the human and great ape brain can tell us about cognitive evolution (HumanUniqueness)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

What makes humans the dominant animal species on the planet? Much of the popular literature has emphasized similarities between humans and our closest animal relatives, especially the chimpanzee. But there can be no doubt that humans are special. A major human cognitive specialization is our ability to process conceptual information. We are able to form abstract concepts by combining sources of information and generalizing from current knowledge. These concepts can be invoked in the absence of immediate percepts and used to recognize exemplars not encountered before (e.g., recognizing a basset hound as a dog even after only encountering beagles in the past). To understand how our brain evolved the ability to process such conceptual information, we need to know what anatomical specializations occurred to allow this behavior. We still know little, but damage to the anterior temporal lobe in humans produces disruption to the production and manipulation of abstract concepts. We also know that the anterior temporal lobe has disproportionately expanded in the humans since our divergence from old world monkeys and that its connections with other parts of the brain have proliferated. Therefore, the goal of the current proposal is to investigate which anatomical specializations have developed in the human brain, compared to that of our closest animal relatives, and whether these are involved in the uniquely human ability to process conceptual information. We will use a combination of ineuroimaging techniques to investigate the organization of the human, chimpanzee, and macaque brains to identify parts of the temporal cortex that are unique to the human brain. Then, using functional neuroimaging in the human volunteers, we will test whether this unique area is indeed activated when people engage in the processing of conceptual information. Together, this presents a unique opportunity to study human uniqueness in a combined comparative and psychological project.

Keywords: mind,chimpanzee,conceptual integration,connectivity,fmri,tractography
Cargo Beacons – no unexpected delays or losses in shipments of valuable cargo (Cargo Beacon)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Sweden
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-11-01
End date: 2017-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Hiotech is an innovative Swedish SME whose ambition is to solve a pressing logistics challenge – to make damages or losses to valuable cargo known to the stakeholders before the goods arrive, so that corrective measures could take place with least impact on manufacturing and supply chains. Realizing that globally almost €90B worth of goods are mishandled or damaged every year, and that there are market segments with stringent requirements on transportation (such as industrial equipment parts or medical substances), Hiotech designed Cargo Beacon – a compact, ruggedized logger of temperature, humidity and shocks. Cargo Beacons are designed to be long-lasting, highly-reusable and low cost – with manufacturing costs at €10 they pose a serious competitive threat to existing loggers with less functionality and a price tag of €100-500. Cargo Beacons communicate their measurements via a dedicated gateway that connects them to a cloud-based data services portal. These services provide additional analytics to the goods owners & recipients and logistics operators. These services include identification of damage cause, optimization of goods flows, reduction of bottlenecks and others. Cargo Beacons are currently on trial with Nefab Group – a packaging solutions OEM, with additional trials pending. During the 6-month feasibility study, Hiotech will validate further the product/market fit of Cargo Beacons in industrial equipment and medical substances markets, and will seek endorsements of this technology from insurance companies that frequently need evidence that goods were transported in full compliance with signed contracts and no damage or wastage took place.

Keywords: freight,cargo,tracking,beacon
Self-adjusting air deflectors for heavy trucks (RMBLStrip)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Sweden
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

RMBLStrip is ultimately a pure software solution that will enable savings of 2-3% of all the fuel consumed by long haul heavy trucks in Europe. The solution has been patented in Sweden and is now to be patented around the world. This project aims at showing feasibility and proof of concept of a technical solution that ultimately can reduce an incredible amount of CO2 emissions in Europe. It also aims at searching for partners for setting up an aftermarket sales distribution as well as for original equipment. Finally, the project also aims at taking the next steps with regards to IP protection and to file a PCT application based on the Swedish patent with a number of heavy-truck relevant designation countries. The purpose with the project is to position Disruptify with a product appealing to European haulers, with huge savings to investment ratio and where a high gross margin is possible to achieve and maintain. The project will help Disruptify to a position were it will be able to attract development funds from industrial actors and/or investments from financial investors.

Keywords: air deflector,boat tail,fuel efficiency
The role of GABAergic circuits in the orchestration of hippocampal neuronal assemblies (GABASSEMBLY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The last decades of research have revealed that neuronal assemblies are fundamental units of brain computation and cognition. The mechanisms of assembly activity may be clinically relevant, because these cells have been shown to be altered in neuropsychiatric disorders such as schizophrenia and epilepsy. Despite the significance of assemblies, it remains unclear how these cells are orchestrated by GABAergic circuits. Here I propose to investigate the role of GABAergic cells in the activity of hippocampal assemblies using in vivo 2-photon calcium imaging and electrophysiology in awake mice. Thanks to a behavioural paradigm designed in the host laboratory, I will be able to discriminate whether the spatiotemporal patterns of GABAergic activity differ between a hippocampal internal mode (limited and constant sensory inputs) and an external mode (richer and changing sensory inputs). Immunohistochemistry will allow the identification of defined GABAergic classes. Next, I will test whether the activity of GABAergic cells is spatially or temporally correlated with the recruitment of hippocampal cell assemblies. Finally, I will investigate in vivo activity and role in assembly recruitment of a particular population of GABAergic cells. This consists of cells that are born early in development and that at early postnatal age exert a ‘hub’ function, namely they trigger powerful synchronisation of hundreds of cells and of network oscillations. Recent evidence has led to the hypothesis that this GABAergic population may play a critical role in the reactivation of cell assemblies during sleep or quiet wakefulness, a phenomenon that is important for memory consolidation. In summary, this project involves a state-of-the-art multidisciplinary approach at the boundary between cellular and system neuroscience. It may provide unique knowledge on the role of GABAergic cells in network mechanisms that are involved in cognition and that appear pathologically relevant.

Keywords: gaba assemblies hippocampus oscillations imaging interneurons inhibition memory
WAVe Resource for Electrical Production (WAVREP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

WAVREP aims to challenge the notion that wave energy should be considered only at energetic regions exposed to open ocean waters. More than 70% of EU coastlines have moderate wave energy resource of 3000-6000 W/m at deployment depths resulting in lower harsh conditions when compared to open ocean coasts. Most Wave Energy Converters (WECs) are developed for higher operational ranges (ocean coasts), with WEC capacity factors and availability at such areas not exceeding 15% and 40% respectively. Higher latitude regions encompass larger wave environments that can propagate high energy content from 5000-8000 W/m. However, such conditions impose significant stresses on the structural integrity and negatively affect expected energy production of WECs, with final capacity factors not exceeding 15-25% (device dependent). WECs at highly energetic wave environment also require higher survivability considerations and have reduced maintenance times. Such factors result at higher capital, operational and energy costs, hindering WECs cost-effectiveness. Using an interdisciplinary scientific methodology the project aims to provide a WEC that can attain higher availability and capacity factors over 60% and 30% respectively, enhancing its global applicability.

Keywords: wave energy,renewable energy,numerical wave modeling,wave energy converters,levelized cost of energy,milder resources