Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A First-in-class novel oral drug for Calcium Malabsorption: Advancing BAFA for Osteoporosis Prevention in Bariatric Patients (BAFA-RYGB)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The global obesity crisis, with over 650 million adults classified as obese and 1.9 billion overweight (WHO), has significantly increased healthcare costs and burdened healthcare systems. This has led to a rise in weight-loss surgeries, such as the highly effective Roux-en-Y gastric bypass (RYGB). However, RYGB surgery substantially reduces calcium absorption, making it nearly impossible for patients to obtain adequate calcium through diet alone. Despite vitamin D and calcium supplementation, post-surgery patients face a significant decline in calcium absorption, leading to long-term deficiencies causing severe health issues. With approximately 250k bariatric surgeries in the EU, the estimated cost for fractures due to calcium deficiency is about €3 billion. RYGB patients, lack medications addressing the root cause of calcium malabsorption, crucial for maintaining healthy blood calcium levels and preventing osteoporosis post-surgery. Epicyt Pharma is addressing this critical gap with the development of 'BAFA,' a first-in-class oral medication for patients at risk of accelerated osteoporosis due to reduced calcium uptake after bariatric bypass surgery. BAFA combines glycocholate (a bile acid) and butyrate (a fatty acid) to enhance intestinal calcium absorption. By bringing BAFA to market, Epicyt pharma aims to capture a significant market opportunity for RYGB patients who currently have no medication to address their unique medical needs. By targeting this specific group with a high unmet need, a global opportunity worth €1.8 billion exists, with of €1.26 billion in the EU and the US alone. We request EIC for a total of €17.5Mn of blended finance to de-risk clinical validation of BAFA to complete clinical validation (Phase IIb and III) of BAFA as the first treatment for post-RYGB surgery. Epicyt Pharma aims to lead in preventing osteoporosis and bone fragility by promoting calcium absorption and ensuring sustained bone health.

Keywords: calcium absorption,rygb,bariatric surgery,osteoporosis,metabolic bone diseases,obesity
A novel tissue containment device for safer minimally invasive gynecological surgeries (LapBox)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Hysterectomy (partial/total removal of the uterus) is the most common gynaecological surgery after the C-section, with 1 in 3 women undergoing the procedure during their lifetime and around 2.7 million surgeries per year. It is mostly related to uterine fibroids, which affect >60% of women and have high associated healthcare costs. Abdominal hysterectomy is still common, as although minimally invasive approaches can bring important benefits their implementation is challenging. When the uterus is removed in a laparoscopic procedure, it is first morcellated (cut into smaller pieces) and then removed through a small incision in the abdomen. However, a usual complication is that residual tissue from the uterus remains in the abdominal cavity. Since 1 in 350 women undergoing a hysterectomy has undiagnosed uterine cancer, the survival of postoperative cancerous tissue in the abdomen means there is a very high risk of it spreading throughout the body. In 2014, the FDA issued a statement calling on companies to develop products that will prevent the spread of uterine tissue during morcellation. Several containment bags are now available, but they all share the same safety and performance limitations. Ark Surgical developed LapBox, a novel medical device that meets the FDA's and the broader medical global community's demand for a safer containment approach in hysterectomy. Our proprietary technology has been integrated into devices for both manual and power morcellation (performed with an electronic device), and it is the first one to guarantee the highest safety thanks to a double-layer wall. It also includes an effective delivery system and a simple handling mechanism, so surgeons can effortlessly implement the system in any procedure. After completing clinical studies in the US and obtaining the FDA approval for the manual version, we now aim to advance in clinical and regulatory issues in Europe to expand our company globally and become market leaders.

Keywords: free keywords max 200 characters women s health,gynecology,hysterectomy,myomectomy,uterine cancers,morcellation,tissue containment system,laparoscopy surgery
First Cure for Parkinson’s Disease: a Revolutionary Disease-Modifying Vaccine (TRIDEM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Austria
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Globally, 8,5 M people with PD rely on symptom-managing therapies that don't halt disease progression, leading to a decline in QoL. L-DOPA (Levodopa) is the gold standard treatment with significant limitations: within five years, 40%-50% of patients develop dyskinesias and motor fluctuations, efficacy decreases overtime and increased dosages are needed, which worsens symptoms. Non-motor symptoms (e.g., depression, pain) are often overlooked and poorly managed, highlighting the need for therapies that address the disease's progression and improve QoL. As PD advances, life expectancy typically drops below 10 years, further impacting patients' well-being. This ongoing progression of PD also places a heavy economic burden on healthcare systems. Annual costs for long-term PD patients in the EU average 40.842€, with long-term care accounting for 69% of these costs, while in the USA costs for privately insured individuals can exceed 100.000 $ annually. Tridem aims to create the first disease-modifying vaccine for PD. By leveraging our patented WISIT vaccine platform, which uses intradermal administration to activate skin dendritic cells, we intend to elicit a stronger, high-avidity antibody response compared to traditional intramuscular or subcutaneous vaccines. Our initial drug candidates, TRB001 & TRB002 (at TRL6), are designed to target the accumulation of misfolded, fibrillar alpha-synuclein (aSyn) in neurons, the root cause of PD. The WISIT-induced antibodies are x50 more selective and x10 more avid for aggregated aSyn (mice). Antibody titer increase has proven to be x7-fold in rats, x10 in mice, and x50 in guinea pigs compared to CCV. In human studies, titers were x40-50 times higher than PD01A (named patient use). We plan to out-license our drug to a pharmaceutical company after demonstrating clinical proof of principle in the Phase 2 study, expected in 2028. This will be funded by Series A and EIC equity. We anticipate total revenues of 1,1 B € from 2029 to 2039.

Keywords: parkinson disease,vaccine,platform,neurodegenerative disorders,antibodies
LIGNin-IRON complexes for removal of nano-plastics in enhanced coagulation-flocculation from water (LIGNIRON)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

Recent advances in lignin nanotechnology have opened up new possibilities not just for underutilized lignin side streams but also for hybrid organic-inorganic nanocomposites. One specific instance is mixing metal ions with lignin nanoparticles (LNPs) to create new materials with desired superparamagnetic properties. Currently, limited knowledge exists regarding the interaction between LNPs and iron, which is what LIGNIRON intends to fill. Additionally, there is no indication of how iron oxide nanoparticles can be encapsulated into LNPs in a reproducible and uniform manner. Identifying these gaps and unlocking the full potential of the lignin-iron complex requires developing fundamental knowledge of the lignin-iron surface chemistry using microfluidic systems where a variety of opportunities exist for studying hybrid material formation. The combination of this knowledge with electrospinning processes would result in a new method that may translate academic research into practical application for continuous mass production of lignin-iron hybrid materials. By achieving these objectives, LIGNIRION paves the way for the application of LNPs into innovative functional materials and creates a new high-volume, high-value end-use for lignin, thereby contributing to the implementation of the EU circular economy policy. Ultimately, the new materials are designed to be used as as retrievable flocculants to remove nano-plastic from water, enabling EU water treatment plants to be effectively prepared for future combat against nano-plastics without significant infrastructure expansion costs.

Keywords: lignin circular economy nano plastic removal inorganic organic hybrid material
Developing the Next-Generation High-Performance RISC-V Simulator to Revolutionise Semiconductor Design Verification and Accelerate Innovation. (SIM-V)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2210000.0
EU funding (EUR): 2210000.0
Participants: 1
Project status: SIGNED

The growing adoption of the open RISC-V microprocessor architecture presents significant verification challenges due to its customisable nature. Verification is estimated to take 10-100x longer than for proprietary, fixed ISAs using hardware-only validation. It also consumes over 50% of commercial CPU design cycles. Efforts are required to streamline RISC-V design by advancing its ecosystem tools to lower integration challenges when combining diverse systems, optimising compilers through common benchmarks, and upgrading fragmented simulators into a unified solution. SIM-V is a proprietary RISC-V simulator that supports all standard extensions through a high-performance instruction set simulation (ISS) approach. Its intuitive extension mechanism provides immediate feedback on designs. It offers software development acceleration, early functional testing, significant cost reduction, and high-efficiency gain for users, therefore effectively improving their performance and output. The EIC project will enhance SIM-V to address a wider range of use cases through standardised versions for automotive, telecom, HPC, and security use cases. Engagement with standards bodies will help establish SIM-V as the reference platform, accelerating RISC-V adoption by facilitating collaboration and reducing individual and ecosystem-wide costs.

Keywords: instruction set architecture,instruction set simulator,verification,simulation
Chiral covalent organic frameworks for spin-selective processes (SPIN-COF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,United States,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2028-04-30
Duration (months): 36.0
Total project cost (EUR): 401232.0
EU funding (EUR): 401232.0
Participants: 3
Project status: SIGNED

In recent times a paradigm shift in chemical reactivity has been induced by the role of chirality. Indeed, chiral structures have the special electronic property of preferentially transmitting electrons with one spin direction. This phenomenon is called chiral-induced spin selectivity (CISS) effect. CISS can play a pivotal role in the control of chemical reaction pathways and it has been exploited to improve the selectivity and efficiency of reactions that involve intermediates of different spin multiplicity, like the oxygen reduction reaction (ORR). Generally, current catalytic systems based on CISS are obtained by anchoring chiral organic molecules to the catalytic units. This approach has some drawbacks, like the reduction of accessibility to the catalytic centers. To overcome this issue and fully exploit the CISS potential, a new generation of catalysts with intrinsic chirality needs to be designed. In this context, covalent organic frameworks (COFs), a class of crystalline porous polymers, are highly promising candidates, as they are tunable and designable. The overall scientific aim of SPIN-COF is to develop new chiral COFs that can exhibit spin-filtering abilities and enhanced catalytic activity. To this aim, during the outgoing phase at Northwestern University, the synthesis of novel chiral COFs will be investigated. In particular, two families of chiral materials will be produced with different elements of structural chirality. Then, the CISS properties of the developed materials will be tested during a secondment period at the University of Florence, carrying out magnetic conductive atomic force microscopy measures. During the return phase at the Max Planck Institute for Solid State Research, the synthesized materials will be tested as catalysts to promote ORR. The effect of chirality on the catalytic performances will be disclosed, setting new perspectives on the control of chemical reactivity using a new generation of chiral materials.

Keywords: covalent organic frameworks,chirality,chiral induced spin selectivity effect,electrocatalysis
Unmanned-Power-to-Methanol-production (UP-TO-ME)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Finland,Germany,Greece,Spain,United Kingdom
Call: Next generation of renewable energy technologies (HORIZON-CL5-2021-D3-03, 2021)
Start date: 2022-11-01
End date: 2025-10-31
Duration (months): 36.0
Total project cost (EUR): 2697500.0
EU funding (EUR): 2697500.0
Participants: 7
Project status: SIGNED

It is a great challenge to upgrade decentralized CO2 point-sources to production sites for renewable fuels. These CO2 sources can be related for example to production of biogas in anaerobic digestion plants. UP-TO-ME targets a ground-breaking change in decentralized Power-to-Methanol production for hard to electrify applications, like marine vessels. The potential of producing renewable methanol, only by utilizing the CO2 content of biogas in Europe is 128 Mt/a. UP-TO-ME concept is based on a hybrid process which combines the capture of CO2 with the synthesis to methanol in a fully autonomous, unmanned plant. The process comprises 3D-printed reactors and column packings designed using highly advanced Computational Fluid Dynamics. The fully automated, self-learning and self-optimizing control system allows production at fluctuating conditions by combining dynamical plant models and Artificial Intelligence. The aim of UP-TO-ME to provide self-optimizing control even for off-grid-operation is very challenging and, to our knowledge, has not yet been achieved anywhere for comparable plants. The ability of a remote plant to adapt itself to varying boundary conditions such as availability of renewable energies (e.g., from weather forecasts) or on the availability of CO2 from a fluctuating source, open unforeseen possibilities for distributed production. Currently, so-called blue methanol originating from natural gas, is used in limited cases as a marine fuel. However, the quality requirements of a renewable marine methanol fuel, especially considering water content, organic and sulfur impurities originating from P2X production, are not known. UP-TO-ME will assess experimentally the suitability of the produced fuel on a marine type of engine and provide ranges for fuel specifications and max limits for impurities for this to become a sustainable marine fuel.

Keywords: p2x,ccu,biogas upgrading,methanol,autonomous plant,metal 3d printing,process intensification,marine fuel
Enabling Massive Integration of PV into Buildings and Infrastructure (MASS-IPV)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Germany,Netherlands,Spain,Switzerland,France,Italy,Cyprus,Norway
Call: PV integration in buildings and in infrastructure (HORIZON-CL5-2023-D3-01, 2023)
Start date: 2023-11-01
End date: 2027-10-31
Duration (months): 48.0
Total project cost (EUR): 8674371.24
EU funding (EUR): 7190188.74
Participants: 20
Project status: SIGNED

A dramatic rise in the implementation of renewable energy sources is needed if we want to meet European climate protection targets. Photovoltaic (PV) costs have decreased spectacularly over time, turning photovoltaics into one of the most competitive sources of electricity in the EU. An economically feasible and space-saving approach to increase the capacity of renewable energy sources is to integrate PV systems into structures that already exist or to build new structures that originally integrate a PV function. Building-integrated and infrastructure-integrated PV are technologically proven solutions. Due to its multifunctionality, building-integrated photovoltaic (BIPV) installations can achieve a better economic and ecological balance over their lifetime than conventional building elements. New technologies for PV cells, electrical connections, and front and back covers allow a free choice of formats and colours for integrated PV modules. Likewise, infrastructure-integrated PV offers a large potential for PV integration, due to the unique advantages of somewhat standardized constructions, little emphasis on aesthetics and a small number of builders and owners compared to the building sector. However, integrated PV (IPV) is still a niche market. Several barriers are still preventing the massive integration of PV into buildings and infrastructure. The project MASS-IPV has been conceived as a multidisciplinary action that connects key players along the PV and construction value chains. The goal of the project is to demonstrate that suitable tools, technologies, and methods, combined with a collaboration framework among key stakeholders, can overcome the barriers preventing the mass deployment of IPV and deliver multifunctional and cost-effective IPV systems for buildings and infrastructure. Six different built objects will be used to demonstrate the technology, representing different construction typologies in five different locations in Europe.

Keywords: bipv value chain,synergie pv green roof,aesthetics,material circularity,substainability certification,easy maintenance,reducing costs,bim planing tools,energy matching
Unlocking the Complexities of Wind Farm-Atmosphere Interaction: A Multi-Scale Approach (WINDFLOW)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Turbulence drives transport processes in the atmosphere and determines Earth’s weather and climate. Wind farm performance depends on atmospheric turbulence as it entrains energy into wind turbine arrays. As wind turbines and farms expand in size, they increasingly interact with an unexplored atmospheric region and large-scale weather phenomena in ways that are not fully understood. Typical wind farm simulations assume idealized cases and do not capture the influence of (i) dynamic changes in atmospheric conditions, (ii) the interaction between the atmosphere and ocean, and (iii) the influence of clouds. In reality, these effects are dynamic and influence atmospheric turbulent flow across a wind farm. Understanding these interactions is crucial to optimize wind farm design, control, and power production forecasts. Far beyond the local scale, wind farm physics impact large-scale atmospheric processes. Outstanding questions include how wind farms influence large-scale weather phenomena, atmospheric stability, moisture dispersion, and clouds. The influence of wind farms on heat and momentum exchange between the atmosphere and ocean is also not fully understood. To bridge these knowledge gaps, I envision using 3D simulations to locally model the wind farm flow physics (microscale) in a weather model (mesoscale). This is a conceptually different approach from typical weather models that use a limited refinement of microscale processes throughout the domain. Using high-resolution simulations, I will go beyond idealized cases and explore dynamic interaction between atmosphere, ocean, clouds, and wind farms. The goal is to study wind farm interaction with realistic weather conditions and provide more accurate wind production forecasts. I will develop novel computational techniques to increase the domain size of high-resolution simulations. Addressing these fundamental modeling challenges is crucial to unlock the complex interaction between wind farms and the atmosphere.

Keywords: turbulence,fluid dynamics,fluid mechanics,wind farm fluid mechanics