Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of the complete workflow for producing and using a novel nanomodified Ti-based alloy for additive manufacturing in special applications. (NANOTUN3D)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Developing next generation nanomaterials, nanodevices and nanosystems
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Germany,Germany,Italy,Belgium,United Kingdom
Call: Additive manufacturing for tabletop nanofactories (H2020-NMP-PILOTS-2015, 2015)
Start date: 2015-10-01
End date: 2019-09-30
Duration (months): 48.0
Total project cost (EUR): 2936657.2
EU funding (EUR): 2936656.25
Participants: 10
Project status: CLOSED

NANONTUN3D will take advantage of the possibilities of Additive Manufacturing (AM) together with the development of a specially tailored Ti- based nano-aditived material to achieve dramatic improvements in structural parts of aero, space, mobility, and equipment sectors, reaching expected savings between 40% and 50% of material in critical applications. inherent benefits of AM will be kept (decrease in throughput times, tool-less production, high buy-to–fly-run ratios, etc.). By adding nano-particles (np) to metal matrixes, the whole life cycle of the NANOTUN3D material has been designed with AM processability in mind: safety and handling issues, processing in well-known AM technologies, postprocessing and eventual certification issues are dealt with, and innovative core-shell treatment of the nano-particles that suits the Ti matrix and produces Ti64-like powder ready to be AM processed. A whole Health, Safety and Environmental (HSE) management system will also be developed, as well as all the protocols to start qualification/certification of material and process.

Keywords: additive manufacturing metal matrix nano composites
Demonstration of new, challenging and high FFA waste oil and fat feedstock in biodiesel process with improved costs, conversion and high fuel quality (BioDie2020)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Austria,France,United Kingdom,United Kingdom,United Kingdom
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2016-1, 2016)
Start date: 2016-12-01
End date: 2019-11-30
Duration (months): 36.0
Total project cost (EUR): 2825586.25
EU funding (EUR): 2119087.01
Participants: 6
Project status: CLOSED

BioDie2020 will recover unconventional, degraded waste oils & fats, notably from Water Company infrastructures, and demonstrate the conversion of these wastes as a sustainable feedstock for biodiesel production. This break-through & beneficial pathway will maximise the use of waste oils & fats on a large scale for the 1st time on the biodiesel market, leading to lower transport carbon emissions. BioDie2020 FTI combines 5 top EU players in an agile & direct value-chain, working on this industry-wide milestone which will improve costs & conversion, achieving high fuel quality. Project coordinator Argent (UK, INDUS), a forward-thinking biofuel leader, will thus demonstrate biodiesel production in a closed-loop business model. 2 key process improvements will go from TRL6 to 7 at Argent’s biodiesel plant (site at Stanlow, UK): i) biofuel technology provider BDI (Austria, SME) will deliver Sulphur reduction in the biodiesel process; ii) microwave technology provider LJMU (UK, Uni) will integrate their bespoke microwave unit to improve pre-treatment of challenging feedstocks. Stagecoach (UK, INDUS), a leading EU captive bus fleet service provider, will perform field trials of final biodiesel. Quantis (France, SME), an ambitious EU SME will perform LCA & LCC analysis of the overall process, ensuring sustainability objectives are achieved. BioDie2020 partners own IP on each technical brick, giving pathways to market & business opportunities. Argent will save ~€5 million/year on feedstock costs, improving ROIC from 12% to 18% by 2019. Demo of BDI’s new process will confer a competitive edge on the retrofit market, giving them a ~25% sales increase by 2020. BioDie2020 will deliver 17 direct jobs and ~100 indirect jobs created or sustained in the EU by 2020. Argent’s ultimate aim is to invest in biofuel deployment via this reproducible waste-to-biodiesel plant (embedded in a closed-loop business model) with market replication by 2020 via commissioning or acquisition & retrofit.

Keywords: biodiesel,demonstration,waste,feedstock,oils and fats,high ffa,conversion,energy efficiency,fuel quality,closed loop business model,commercialisation,biofuel,circular economy
Identifying spatial determinants of immune cell fate commitment (ImmuNiche)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-07-01
End date: 2025-06-30
Duration (months): 72.0
Total project cost (EUR): 1997500.0
EU funding (EUR): 1847706.25
Participants: 2
Project status: SIGNED

The complex architecture of the mammalian hematopoietic system has been studied for decades, yet the molecular mechanisms underlying cell fate commitment remain poorly understood. Although cytokine signals are major determinants of hematopoietic cell fate, only few niches of stem and progenitor cells have been characterized. Here, we propose to resolve the cell type composition of mouse bone marrow by integrating single-cell RNA-seq with high-resolution spatial analysis of gene expression in tissue sections, visualizing ~250 cell type specific markers by multiplexed single-molecule RNA fluorescent in situ hybridization. This approach will reveal preferential co-localization of hematopoietic cells with other bone marrow-resident cell types, and globally predict niches of hematopoietic progenitor sub-types to pinpoint microenvrionmental determinants of hematopoietic cell fate. Based on this reference we will investigate the role of the microenvironment in the pathogenesis of myelodysplastic syndromes (MDS), representing one of the most frequent blood cell malignancies, commonly giving rise to leukaemia with poor prognosis. To investigate conservation of microenvironmental determinants of normal and malignant hematopoietic differentiation in human, we will apply the same strategy to healthy donors and human MDS patients and compare predicted cell types, differentiation trajectories, and niche interactions to those derived from healthy mice and murine MDS models. This approach will reveal conserved niche regulators of cell fate commitment involved in disease pathogenesis, which we will functionally analyse in murine models to identify novel therapeutic targets for prevention and treatment of MDS. Our approach represents a blueprint for investigating human malignancies of under-characterized tissues by applying cutting-edge high-resolution techniques in combination with advanced computational methods to jointly analyse the murine model and human patient microenvironment.

Keywords: single cell rna seq,spatial gene expression analysis,hematopoiesis,microenvironment,myelodysplastic syndrome,leukemia
Next generation of memory for the age of IoT (IoTMemory)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Serving the €17bn microcontroller industry: Every IoT device needs a microcontroller (MCU). Each MCU has logic transistors for processing data and eNVM (flash) for storing data, among other components. Most microcontrollers today are manufactured at 40nm nodes or above. Smaller technology nodes, like 28nm, promise lower power and lower cost, critical for IoT adoption. Logic transistor scale down fine to 28nm and below. But Flash does not scale down to smaller technology nodes – the effects of Moore’s law have hit a physical limit at 28nm for Flash memory; writing data will destroy them. Consequentially, the benefits of 28nm will be denied to MCU vendors, unless a new eNVM technology is found. FeFET, the ferroelectric field effect transistor by FMC, is based on the discovery that hafnium oxide, the gate material of modern logic transistors, can be modified such that it becomes ferro-electric. By applying a positive or negative voltage, the material can store a 0 or 1. The gate remembers the state even when power is turned off – the transistor becomes a non-volatile memory cell. As hafnium oxide retains ferro electricity to at least 2nm film thickness, we have clear path to eNVM cells even at the 7nm node – the most advanced technology node available today. In Phase 1, FMC wants to better understand the technical requirements in various sectors of the microcontroller market, develop a communication approach, and develop a detailed plan how to meet their application specific functional and performance requirements. Today, FMC is focused on advancing its technology from TRL5 to TRL6 to satisfy minimum viable product properties ahead of commencing prototype production. In Phase 2, FMC will use the base technology to create a range of custom-specific memory macros that satisfy the requirement of different market segments and customer types (TRL7-8). The company should reach more than 115M€ revenues by 2024 provided it can raise the required financing.
Verifying Authenticity with Liquid crystal-Derived Anti Theft Encoding (VALIDATE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Luxembourg
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-09-01
End date: 2021-06-30
Duration (months): 22.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Product counterfeiting, sometimes related to the theft of the original, has emerged as a significant economic issue, with the market value of pirated products equalling or exceeding the gross domestic product of some European countries. A 2016 report from OECD in cooperation with the EU Intellectual Property Office (EUIPO) found that in 2013 counterfeit products sold were worth €375 billion, totalling 2.5% of global trade. Counterfeit products range from high-end consumer luxury goods, to business-to-business products such as machines, chemicals, raw materials or spare parts, and to common consumer products such as toys, pharmaceuticals, cosmetics and food. Some counterfeit products, in particular in the latter category but also, e.g., spare parts, are of low quality, thus creating additional health and safety threats. Valuable raw materials can be stolen at the site of production or in transit, sometimes being replaced by a copy that can be difficult to detect as such by the receiver, sometimes reappearing on the market with no means to detect them as stolen. VALIDATE aims to investigate the commercial feasibility of Cholesteric Spherical Reflectors (CSRs) coatings as high-security identification tags, within a work plan that aims to take our innovation from a Technology Readiness Level (TRL) of 4 to 6/7. This will serve as a key stepping stone towards full commercial exploitation of our CSRs as a game-changing material for authentication. The value proposition of VALIDATE is a physical identifier tag that is effectively unclonable as a result of the manufacturing process, naturally tamper-evident and hard to simulate due to the complexity of the generated patterns. VALIDATE’s end goal is to have a comprehensive description of the commercial feasibility of our technology and, if positive, what commercialization route has the best risk/benefit ratio.

Keywords: anti counterfeit,anti theft,supply chain security,track and trace
Development of a commercially-viable system for the automatic generation of high-throughput well-defined microdroplets (AutoMonoDroplet)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: France
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 86250.0
EU funding (EUR): 86250.0
Participants: 1
Project status: CLOSED

Emulsions are widely used in industries such as foods, cosmetics, pharmaceuticals and chemicals. However, most of the emulsions used consist of polydisperse droplets. Emulsions of monodisperse droplets have many advantages, including higher stability (i.e. longer shelf life and minimization of additives) and more controllable physical properties, including drug encapsulation and release properties. Small scale production of monodisperse emulsions is available using microfluidics technology. However, to increase the production rate of the emulsions to industrial production levels (L/h) coupled flow microfluidics chips and fully automated system is required. We have all of the high-performance tools at Elvesys to build such a device (high speed, extremely stable pressure controller and switcher, leader in optical droplet detection tools). However, we are lacking an Innovation Associate with the knowledge to carry out such a project and are unable to find such a person in the local market. To create such a high throughput automated system we are seeking an associate who is enthusiastic about entrepreneurship with technical skills in microfluidics, high precision microfabrication, flow control and automatization which we are lacking in the company. We will train this candidate in entrepreneurship from the perspective of a start-up company and encourage him/her to start their own spin-off company with the instruments they build. Elvesys’ long-term strategy is to be leading provider of microfluidic solutions to science and industry. It is expected that the innovation associate will bring new expertize and technical knowledge while implementing our vision towards automated monodisperse droplet production system which is in high demand from scientists and industry working with emulsions.

Keywords: droplets,automation,instrumentation,start up,cosmetics,drug encapsulation,microfluidics
Land, Property and Spatial Justice in International Law (PROPERTY[IN]JUSTICE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Ireland
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

This project will scrutinize the concept, definition and interpretation of property rights in international law as they relate to land. It will not only examine the international human rights, environmental and cultural heritage law frameworks, but also specific areas of international economic law, including investment, that converge and diverge with spatial justice in the realm of land-based projects and policies. Lastly, the project will also include a strong conceptual component, by ascertaining to what extent a reconceptualization of property can contribute to transforming international law from ‘tool of empire’ to vehicle for change. Globalization has significantly affected the ways in which communities in many parts of the world interact with and access land and resources – from changing farming patterns due to international trade agreements, to collective tenure and customary rights in landscapes that are simultaneously the location of large-scale resource extraction projects. At the same time, normative developments in the field of human rights and environmental protection provide for the recognition of communities’ rights to ancestral and communal lands, as well as the free, prior and informed consent of communities in order to conduct activities on such lands (e.g. UNDRIP). Yet the abstract notion of ‘property’ rights in international investment law (land as commercial asset) often collides with the ‘lived-in’ property rights of people and communities on the ground (land as the basis for social, cultural and ecological life). As noted by Cotula, “far from being relegated to the exclusive domain of national law, property has long been and remains an important issue in international legal ordering” (2017, 234). Yet despite its centrality, its impact on people-place relations remains under-scrutinized in the international law scholarship. This project aims to fill this lacuna.

Keywords: land,property,environment,spatial justice,international law
COMMUNITIES FOR SCIENCES (C4S) Towards promoting an inclusive approach in Science Education (C4S)

Framework: Horizon 2020 — Science with and for Society
Programme: Integrate society in science and innovation issues, policies and activities in order to integrate citizens' interests and values and to increase the quality, relevance, social acceptability and sustainability of research and innovation outcomes in various fields of activity from social innovation to areas such as biotechnology and nanotechnology
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Spain,Italy,Hungary,Belgium,Bulgaria,Sweden
Call: Building the SwafS knowledge base (H2020-SwafS-2019-2-two-stage, 2019)
Start date: 2020-10-01
End date: 2023-11-30
Duration (months): 38.0
Total project cost (EUR): 1154516.25
EU funding (EUR): 1154516.25
Participants: 11
Project status: SIGNED

AIM: Communities for Sciences (C4S) will be developed in 9 European cities (Milan -Italy-, Brussels -Belgium-, Manresa -Spain-, Vic – Spain-, Vienna -Austria-, Budapest -Hungary-, Sofia -Bulgaria-, Lund -Sweden- and Berlin -Germany) and their areas of influence. The activities that will be implemented will be coordinated by a local Hub in 6 cities with the leadership of one of these local partners of the Consortium. Each Hub will focus on a specific vulnerable community (immigrants, Roma community and disabled citizens) working with and for children and youth aged from 0-16 years old and their families. C4S will study the relationships between science and society by focusing upon vulnerable communities due to the fact that they are often not visible as active social agents. It is necessary not only to create activities for them, but also to include them as co-participants of these activities in order to ensure a more coherent approach towards inclusive education and to promote anticipatory policy-making. This will be done through science education activities, through formal and non-formal educational institutions, from an inclusive standpoint, to provide them with better science awareness and capacities and to make them progressively aware of exclusionary practices that at times may occur in science. Special emphasis will be put on engaging them in an intersectional approach to fight against the gender discrimination suffered by women and girls on multiple levels. In addition to this, each HUB will engage with policy-makers, educators and institutional representatives to promote their role in supporting and promoting an inclusive science education approach and to consolidate such inclusive practices on more solid grounds.

Keywords: science education,inclusion,diversity,disability,immigrants,roma,children,youth,families,society,gender,governance,awareness
Unravelling host intestine-parasite interactions that define immune responses to whipworms (GUTWORM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-11-20
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Whipworms (Trichuris trichuira) are soil-transmitted helminths that infect about 700 million people in the tropics and sub-tropics and cause the human disease, trichuriasis. Whipworms live preferentially in the cecum of their hosts where they tunnel through epithelial cells and cause inflammation potentially resulting in colitis. Despite extensive research, the role of whipworm interactions with epithelial and immune cells in triggering parasite expulsion remains unclear, hindering the development of anti-parasite therapies. The ultimate goal of my research proposal is to investigate and understand this interaction in detail. To achieve this, I will use T. muris, a mouse model of T. trichuira infection in humans. This research proposal has three key aims. First, to identify new parasite and host genes that could interplay and modulate immunological outcomes. Second, to characterize the role of host genes in whipworm infection and immunity. Here, novel and known candidate mutations conferring susceptibility to colitis identified through the Wellcome Trust Sanger Institute - Mouse Genetics Project will be targeted. Thus, I will challenge mutant mouse lines with T. muris and evaluate the influence of these mutations on anti-parasite immunity and expulsion. Finally, upon identification of key genes regulating the immune response to whipworms, I will explore the mechanism of action of selected genes and their effect on the parasite. For this, I will take advantage of the vast range of ‘omic’ technologies and facilities available at the WTSI. This project will generate novel fundamental data on host-whipworms interactions and also support future efforts to control these parasites by the identification of potential new therapeutic targets. Moreover, resulting knowledge of the parasiteimmunological interplay could be exploited to understand other intestinal inflammatory diseases such as ulcerative colitis that have many similarities with trichuriasis.

Keywords: whipworms,intestinal epithelial cells,host parasite interaction,trichuriasis,trichuris muris,intestinal immune system