Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
COmmunity Ocean farms and Local Business cLUstErs (COOL BLUE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Coordination and support actions
Countries involved: Germany,Denmark,Sweden,Finland,Estonia
Call: Towards local community-driven business models: regenerative ocean farming (HORIZON-MISS-2022-OCEAN-01, 2022)
Start date: 2023-04-01
End date: 2026-03-31
Duration (months): 36.0
Total project cost (EUR): 998587.5
EU funding (EUR): 998587.5
Participants: 12
Project status: SIGNED

Coastal and terrestrial fisheries communities in Europe, often economically marginalised, are likely to face severe impacts as climate change becomes more acute. Although progress on climate mitigation and adaptation from national governments remains slow, local development actions can also address these impacts from the bottom up. Transformation to a post-carbon society undoubtedly requires additional, targeted support and extensive educational activities at the local level. The primary objective of COOL BLUE is to create frameworks for communities to self-organise and rediscover healthy, low-impact seafood. This healthy, beautiful, tasty food simultaneously revitalises ecosystems while bringing communities closer together, creating resilient, self-sufficient and self-sustaining socioecological systems which can withstand emerging global threats such as climate and demographic change. The COOL BLUE project will create a Northern European network of community-led initiatives in the Baltic and North Sea basins. This network will facilitate closer collaboration between regions, combining efforts across parallel projects and initiatives (e.g. PREP4BLUE, BlueMissionBANOS), while accelerating the development of commercially self-sustaining, low-impact, inclusive ocean farming systems in line with the Mission Work Programme to contribute to the recovery of our ocean and waters by 2030.

Keywords: seaweed,shellfish,permaculture,community
Traditional Knowledge for the Conservation of the Silk Roads Monumental Terracruda Sculptures (TANTRiC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

It is in Central Asia, that more than 2,000 years ago, the art of making monumental terracruda sculptures become one of the most significant expressions of knowledge transfer along the Silk Roads. Despite the wide distribution of this art and its historic relevance, we still lack a scientific understanding of the manufacturing of these sculptures. Consequently, preservation remains a challenge. Recent studies have shown that monumental terracruda sculptures are still produced in some areas of Himalaya (Bhutan) and India (West Bengal) and, although the precise materials may vary, the technological pattern remains unchanged over time. This pattern is the result of a specific knowledge acquired and transmitted over centuries. TANTRiC will study and valorise this traditional knowledge to unveil the cultural significance of this unique artistic practice, as well as to inspire, through scientific criteria, innovative and sustainable solutions for the conservation of these sculptures. TANTRiC proposes an interdisciplinary methodological framework in the domain of heritage science combining: ethnographic research, materials science and conservation. The objectives are: 1) documenting the empirical knowledge of making these sculptures, 2) analysing samples of archaeological sculptures to compare ancient and contemporary materials and additives, 3) carrying out a battery of simulations-tests to analyse the behaviour and properties of the clay-based mortars, inspired by traditional “recipes”. The expected results will be: a) improving the understanding, significance and evolution of the artistic practice of making monumental terracruda sculptures; b) enhancing and valorising the traditional knowledge for making these sculptures; c) informing new evidence-based conservation treatments; d) demonstrating that exploring the traditional use of green materials represents an innovative solution for the design of more sustainable and responsible heritage conservation strategies.

Keywords: heritage science,conservation restoration,archaeometry,traditional knowledge,green materials,silk roads,arts and crafts
Advanced, trustworthy AI and data solutions for individualised automated milking & feeding of dairy cows (dAIry 4.0)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Cyprus,Netherlands,Spain,Greece,Austria,Switzerland
Call: AI, Data and Robotics for Industry optimisation (including production and services) (AI, Data and Robotics Partnership) (IA) (HORIZON-CL4-2022-DIGITAL-EMERGING-02, 2022)
Start date: 2023-10-01
End date: 2027-03-31
Duration (months): 42.0
Total project cost (EUR): 3533843.75
EU funding (EUR): 2957356.25
Participants: 7
Project status: SIGNED

The agricultural sector has a big challenge: producing more with fewer raw materials and less adverse effects on society, production animals, climate and biodiversity. Optimal use of resource is even more important now, due to the imminent food crisis. Climate-friendly sustainable agriculture, with care for natural resources, is essential for our food production and quality of life, today and for future generations. Automated Milking Systems (AMS) were developed in the late 20th century under the perspective of reducing manual labour & costs and improving quality of life for the farmers. Not only have these machines improved in harvesting milk efficiently, but they also have the added ability to collect a greater amount of data about production, milk composition, cows health and behaviour. This could allow producers to make more informed management decisions, while in parallel reducing emissions and increasing animal welfare. Nevertheless, currently available AMS have important limitations in terms of optimising their operation. dAIry 4.0 addresses these challenges, integrating and optimising AI, data and robotics solutions to demonstrate how this combination will optimise AMS production aspects and minimise adverse effects on society, climate and biodiversity. The approach will be demonstrated through real-world use cases of interest both for the farming sector and the food industry. In terms of AI tools to be used, the project will focus on the following novelties: - Developing multimodal learning techniques to efficiently utilize multiple types of information for animal health & overall animal status monitoring - Developing self-supervised and novel data augmentation techniques to reduce the amount of labelled training data needed - Exploring novel explainable AI techniques to increase transparency of the system and eventually facilitate acceptance by the users - Including the farmer in the loop to build the cognitive abilities for the system

Keywords: ai,automated milking systems,milk quality analysis,decision support systems
Elucidating and targeting the mechanisms encoded in the genome of long-lived individuals to improve healthy ageing (ElucidAge)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany,Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-08-01
End date: 2027-07-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: SIGNED

Advancing age is the major risk factor for many serious illnesses, including cancer, cardiovascular disease, and dementia. The rising number of older individuals is thus causing a major burden of ill health. However, individuals that reach an exceptional old age often seem to escape or delay age-related diseases, and part of this trait seems to be encoded in their genome. Hence, by studying the genome of long-lived individuals, we may be able to identify mechanisms that could be targeted for healthy ageing in the general population. My previous work suggests that large genome-wide association studies (GWAS) of long-lived individuals can be used to identify genetic variants involved in longevity. However, the common genetic variants thus far identified using GWAS only explain a minor part of the genetic component of longevity. This trait, therefore, may well be mainly determined by rare genetic variants, which can be detected using whole-genome or exome sequencing of long-lived families or exceptionally long-lived individuals. The aim of the proposed project is to establish the effect of genetic variants identified in genetic studies of long-lived individuals on general health and lifespan using cellular models and, subsequently, model organisms. To this end, I will use CRISPR/Cas9 gene editing to generate transgenic cell lines and mice that harbour genetic variants in candidate genes and pathways identified through GWAS and sequencing studies of long-lived families and individuals. I will subsequently use this information to create a high-throughput screening assay to identify compounds that can pharmacologically recapitulate the observed in vitro effects. As a proof-of-principle, I will start with functional characterisation of rare variants in genes involved in insulin/insulin-like growth factor 1 (IIS) and mammalian target of rapamycin (mTOR) signalling, given the well-known role of these networks in ageing in pre-clinical model organisms.

Keywords: functional characterisation genetic variants crispr cas9 longevity lifespan healthspan model organisms high throughput screening drug discovery
The enforcement of EU Competition Law in the pharmaceutical sector: before, during, and after a health crisis (learning from the COVID-19 Pandemic) (COMPHACRISIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-09-30
Duration (months): 25.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 1
Project status: CLOSED

COMPHACRISIS will be carried out in line with the Pharmaceutical Strategy for Europe, under the supervision of Professor Imelda Maher at University College Dublin (UCD). The main question of the research is: what are the significant differences between normal, crisis and post-crisis EU competition law and policy in the pharmaceutical sector? Analysing the normal enforcement of competition law, evaluating the crisis enforcement of competition law, exploring the significant consequences of the crisis policies in the post-pandemic law and designing an Effective Health Crisis Competition Law Framework are specific objectives of COMPAHCRISIS. The European Union competition law enforcement and three member states (Germany, Italy, and Ireland) will be reviewed in COMPHACRISIS. To conduct the project, both the semi-structured interview method and doctrinal method will be used. COMPHACRISIS leads to significant improvement of my scientific profile, better networking with the research and industrial community through interviews, workshops, seminars and conferences, and helps me gain different skills such as project management skills, qualitative and quantitative skills, mentoring, grant writing, interview and analytical skills. I will also take some courses in Econometrics methods and Health Policy. I will be able to submit papers in English to leading international competition law journals and learn new research methods and teaching skills from my supervisor. The results of COMPHACRISIS will be published in prestigious journals, and I will present my research at well-known and international conferences. We will also organise two specialised workshops in UCD. Using social media and social networking tools to present the work is among the COMPHACRISIS communication activities. COMPHACRISIS will lead to a new approach in understanding the importance of competition law in the pharmaceutical sector during and after a crisis, and influence European policy-makers and legislators.

Keywords: competition law,antitrust,competition policy,competition authority,european commission,state aid,pharmaceutical sector,health law,pandemic,post pandemic,eu law,health sector
A PRAGMATIC CLINICAL STUDY OF NEOADJUVANT CHEMOTHERAPY FOLLOWED BY SURGERY VERSUS SURGERY ALONE FOR PATIENTS WITH HIGH RISK RETROPERITONEAL SARCOMA (STREXIT2)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Research and Innovation actions
Countries involved: Belgium,Italy,Netherlands,Hungary,Germany
Call: Pragmatic clinical trials to optimise treatments for patients with refractory cancers (HORIZON-MISS-2022-CANCER-01, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 4971875.0
EU funding (EUR): 4971875.0
Participants: 5
Project status: SIGNED

Retroperitoneal sarcomas are rare diseases refractory to treatment with dismal prognosis. Surgery is the only standard approach to primary disease. We are proposing an innovative pragmatic approach supplementing a standard phase III clinical trial with an observational cohort. It is proposed to amend the ongoing phase III EORTC clinical trial STRASS2 investigating the added value of neoadjuvant chemotherapy before surgery for high-risk retroperitoneal sarcoma and to add an observational arm STREXIT2 that will capture real world data from patients not participating to STRASS2. We will compare the clinical outcomes between STRASS2 and STREXIT2 and explore the possible combination of STRASS2 and matched STREXIT2 patients to strengthen the results of the randomized clinical trial data and increase the power of subgroup analyses. If conclusive, the proposed research will help to understand the clinical added value and costs-effectiveness of neoadjuvant chemotherapy before surgery for high-risk retroperitoneal sarcoma. We will perform health economics analysis assessing the economic value of different treatment scenarios based on STRASS2 and STREXIT2. If successful, the outcomes of the project will define a new evidence-based standard of care for high-risk retroperitoneal sarcomas. The proposed research could lead to improved patient survival and quality of life but also improving health system sustainability. This is a multidisciplinary and multistakeholder consortium involving clinical oncologists, surgeons, health economists and patient representatives. The study design was successfully discussed with patients. This action is part of the Cancer Mission cluster of projects on ‘Diagnosis and treatment’.

Keywords: retroperitoneal sarcoma,chemotherapy,health economics
Large area uniform industry compatible perovskite solar cell technology (LUMINOSITY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Netherlands,Germany,Italy,Denmark,Belgium,Cyprus,Switzerland,Sweden,Czechia
Call: Large Area Perovskite solar cells and modules (HORIZON-CL5-2023-D3-02, 2023)
Start date: 2024-06-01
End date: 2028-05-31
Duration (months): 48.0
Total project cost (EUR): 7607805.5
EU funding (EUR): 6996063.13
Participants: 15
Project status: SIGNED

LUMINOSITY is an industry driven project aimed at leveraging the flexible perovskite solar cells (PSC) technology to commercially relevant production scales, using established industrial processes. The objective of the project is to demonstrate roll-to-roll (R2R) processed photovoltaic (PV) module with power conversion efficiency (PCE) of >20% at an area of >900 cm2, and thus overcome the efficiency gap between lab-scale and fab-scale processed devices, elevating the TRL up to 7. One of the unique selling points of this work is the commercial substrate foil based on aluminum with fluorinated-tin-oxide (FTO) electrode layer, which is an intellectual property of HyET Solar, the end user in the consortium. By using this substrate foil, LUMINOSITY will alleviate the bottlenecks related to limited process window of typical polymer substrate foils – such as high quality nickel oxide charge transport layer deposition (requires 300ºC thermal process) – to reach high stability, efficiency, and lower environmental impact, while keeping the flexibility. The consortium encompasses the full value chain from research and technology developers, equipment manufacturers, suppliers, and industrial end-users. Together, we are well-equipped to surmount the existing challenges that have hindered the widespread adoption of PSC technology. Specifically, LUMINOSITY will achieve operational stability exceeding 20 years that rivals the lifetime of current commercial thin film PV technologies, while ensuring economic (0.14 USD/W at R2R production scale) and environmental feasibility (50% lower CO2 foot-print in comparison to c-Si PV), substantiated by comprehensive Life Cycle and Techno-economic Analysis. LUMINOSITY will fast-track the market uptake of flexible perovskite PV technology and thus enable rapid increase of PV installation capacity in EU to reach the goals set by REPowerEU plan.

Keywords: perovskite solar cells,roll to roll processing,metal halide pervoskite
Lifting up the working poor: predistribution and redistribution at the low end of the wage spectrum (LIFT-UP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1445656.0
EU funding (EUR): 1445656.0
Participants: 1
Project status: SIGNED

Minimum wages and taxes and transfers are prominent examples of pre and redistributive policies in the area of low pay in Europe and the U.S. Despite their pervasive coexistence and extensive research on their effects, the two have been mostly studied in isolation. This has limited our ability to evaluate their interplay in the labor market and identify joint design options to effectively support the working poor. With these goals, our first contribution is to examine the pre and redistributive components of low-income support jointly. We will develop an empirically grounded model of the low-wage labor market, which can be used to evaluate the impact of alternative joint designs of minimum wages and taxes on labor market equilibrium in a realistic way. This requires new empirical evidence on how the two interact and on the fundamental features of the market environment in which they operate. Minimum wages are widely popular, although according to standard normative theory their existence is not justified if governments can redistribute with taxes. Why, then, are minimum wages so socially and politically successful? Our second contribution is to uncover what drives support for pre and redistribution to the working poor. Besides enriching our knowledge of the political feasibility of reforms in this area, evidence on policy preferences will be central to characterizing an optimal redistribution policy based on a new notion of welfare desirability, which considers not only the material interest of individuals as market participants, but also their policy preferences as citizens. Academically, this is groundbreaking since it overcomes multiple empirical and theoretical divides in both positive and normative analysis, with the end goal of characterizing the optimal configuration of low-income support policies. Practically, it will provide guidance for concrete reform actions, highlighting their economic and distributional implications and their political feasibility.

Keywords: public economics,labor economics,social economics,labor market inequality,minimum wage,taxes and transfers
Revolutionize the treatment and long-term healing of Diabetic Foot Ulcer (DFU) (CAREGLASS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 48.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

Diabetes-related lower-extremity complications are a leading cause of the global burden of disability. Every 20 seconds in the world, someone will lose a limb due to diabetes. Among the many complications of this chronic disease, diabetic foot ulcers (DFUs) remain one of the most devastating—and least discussed. Affecting millions globally, DFUs are not just wounds; they are gateways to lifelong disability, social isolation, and premature death. The current treatments (advanced dressings, cell-based matrixes and bioresorbable polymers) fail to heal DFU. For one, they are often used when it is already too late. Moreover, the recurrence rate is alarmingly high despite these treatments, and there is no true healing with non-recurrence. In this context, NORAKER has developed CAREGLASS, the world-first Bioglass-based continuum of products that transforms a passive wound dressing into an active, regenerative interface, initiating a cascade of cellular and molecular events that mirror natural tissue healing processes, from the earliest stage (superficial wound level 1) to an advanced stage (deep wound level IV). To date, CAREGLASS prototypes have been validated in a relevant environment, bridging the gap between lab testing and operational deployment. TRL5 activities have all been completed. In this EIC Accelerator project, the CAREGLASS will be clinically validated, industrialized, and deployed to the international market. This unique medical device will enable to treat DFU with the urgency it deserves, and contribute to stop the silent suffering of millions of patients. Every patient will now have a chance to overcome the infection. With CAREGLASS, NORAKER’s goal is to eliminate preventable amputations from DFUs over this next generation. Upon successful completion of this project, NORAKER will address the specific segment of DFU in both the EU and the USA, and expect an EU market share of 20% and 10% in the US, generating a revenue of €33m by 2035.

Keywords: diabetic foot ulcer,non healing wounds,bioglass processing,implants,soft tissue regeneration