Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Proton transport and proton-coupled transport (PROTON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria,Germany,Germany,Germany,Israel,Germany,Germany,Austria,Switzerland,Norway,Romania,France,Czechia
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-09-01
End date: 2024-07-31
Duration (months): 59.0
Total project cost (EUR): 3920811.13
EU funding (EUR): 3920811.13
Participants: 13
Project status: SIGNED

Secure, competitive, and sustainable energy production is a major challenge facing human societies. Biomimetic solutions such as the development of new biofuel cells are hampered by our thus far incomplete understanding of proton transfer reactions. The same holds for health threats to humanity: Curing diseases like cancer, obesity, chronic gastritis, gastric and duodenal ulcers, requires to pharmacologically interfere - in their molecular details - with yet unresolved proton transfer reactions. Here we aim at clarifying the molecular reaction mechanism in the confines of interfacial water layers and proteinaceous cavities with emphasis on arrangement and mobility of proton relay moieties. Achieving this requires an interdisciplinary, multi-level approach comprising cutting edge technologies like second harmonic imaging, single molecule and time resolved fluorescence microscopy and spectroscopy, advanced calculations of proton transfer, bioengineering of membrane channel and transporter containing systems, synthetic design of biomimetic proton channels, solving protein structures and rational drug design. PROTON will train 15 PhD students, who will acquire a solid state-of-the-art multidisciplinary scientific training in all kinds of proton migration/reaction systems, covering from basic science to industrial applications, thus preparing them to generate new scientific knowledge of the highest impact. In addition, practical training on transferable skills will increase their employability and qualify them for responsible positions in private and public sectors. Cross-disciplinary strategies and close collaboration with industry will enable them to resolve the molecular details of proton driven processes in all kinds of settings - enabling the improvement of biomimetic applications – up to fuel cells - and to identify lead substances which may serve to pharmacologically interfere with proton transport through membrane channels and transporters.

Keywords: synthetic organic chemistry,theoretical and computational chemistry,physical chemistry of,biological systems,optical physics
European forum and oBsErvatory for OPEN science in transport (BE OPEN)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Germany,Germany,Austria,Spain,Ireland,Italy,Cyprus,Belgium,Serbia,Greece,Hungary,Lithuania,Poland,Norway,Greece,Greece,France,Czechia,Netherlands,United Kingdom,Portugal
Call: Building Open Science platforms in transport research (H2020-MG-2018-SingleStage-INEA, 2018)
Start date: 2019-01-01
End date: 2021-06-30
Duration (months): 30.0
Total project cost (EUR): 1997283.75
EU funding (EUR): 1997283.75
Participants: 25
Project status: CLOSED

BE OPEN aims to create a common understanding on the practical impact of Open Science and to identify and put in place the mechanisms to make it a reality in transport research. Achieving Open Access to publications, making their underlying data FAIR (Findable, Accessible, Interoperable, Reusable) and open where possible, and using open and collaborative processes and infrastructure via the European Open Science Cloud (EOSC) will be key factors in making transportation researchers share-reuse-reproduce science and in bringing such a critical sector closer to the society for enabling open innovation and citizen science.Openness, transparency, fairness, reproducibility of science are key aspects around which BE OPEN will seek to establish the ground rules for the transport research communities, ultimately establishing a community of transport research organizations willing to work on the basis of a commonly agreed “Open Science Code of Conduct”. To this end, BE OPEN has brought on board key transport and open science related communities in a two-fold action plan: to engage them in a participatory approach fostering a dialogue on Open Science (what exists, what should be done, how it should be done) among relevant stakeholders in Europe and around the world, and develop a detailed roadmap for the implementation of sustainable open science modules which include key practices, infrastructures, policies and business models, all taking into account the specificities of the transport research domain, and the use and integration of existing-infrastructures and the emerging EOSC initiative.
Genetic correction of glycogen debranching enzyme deficiency in Glycogen Storage disease III: a proof of concept study (GLYCODIS3)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Glycogen storage disease III (GSD III) is a rare (1:100,000) autosomal recessive disorder that results from the deficiency of the glycogen debranching enzyme (GDE). The major cause of morbidity is associated with the muscle accumulation of glycogen, which leads to progressive myopathy. A dietary treatment with frequent meals high in carbohydrates, slows the progression of the pathology that is however inevitable. There is no cure for GSD III, the recent development of a mouse model lacking GDE activity, which recapitulates the human condition, represents a unique opportunity to develop and test novel therapies for the disease. Here, we propose to perform a proof-of-concept study of an adeno-associated virus (AAV) vector-mediated gene therapy for the treatment of GSD III. AAV gene therapy has been successfully used for the correction of several genetic diseases in animal models and humans. One of the main limitations of AAV vectors is that they cannot package vector genomes significantly larger than 5kb. Due to the length of the sequence of the GDE enzyme (4596 bp), we engineered a dual-vector system with a recombinogenic sequence to drive reconstitution of the full-length GDE sequence. In alternative to this strategy, we engineered also a truncated GDE that can fit in a single AAV. Because GSD III is both a liver and muscle diseases, and because the liver is involved in glycogen metabolism and, ultimately, in the supply of glucose to the muscle, we will test two main therapeutic strategies to treat GSD III, consisting of constitutive or liver-specific expression of the transgene. The rescue of the GDE enzyme deficiency will be carried out in vivo in a GDE KO mouse, and in vitro in human iPS cells-derived hepatocytes and myocites. We will generate fibroblast-derived iPS cells from GSD III patients and the pluripotent cells will be successively differentiated in hepatocytes and myocites.

Keywords: gene therapy,glycogenosis type iii,neuromuscular disorders,liver,muscle,glycogen debranching enzyme,induced pluripotent stem cells,myocyte,hepatocyte,fibroblast
Maximising wellbeing and minimising emissions: backcasting social visions for a low-carbon Europe. (MAXWELL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Finland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-14
End date: 2017-09-13
Duration (months): 24.0
Total project cost (EUR): 179325.6
EU funding (EUR): 179325.6
Participants: 1
Project status: CLOSED

The science of climate change demands radical long-term reduction in greenhouse gas (GHG) emissions. In supporting this, EU policy is committed to develop a low-carbon future by 2050 . Key to meeting this target is the contribution of energy and both analysis and policy development have been prioritised. The central planks of mitigation practices globally include technological change and efficiency. It is widely acknowledged that the challenge of mitigation fundamentally requires more , as emissions are dependent on the wider development path and underlying driving forces. Within these concepts exists not only the challenge of more complex analysis, but the opportunity of new ways to reduce energy consumption. A neglected but promising option is to look at the social structures underlying material consumption. The perception of mitigation policy is of cost and loss, but there is potential to deliver mitigation while improving peoples´ lives, to maximise wellbeing and minimise emissions. This study will backcast scenarios of social wellbeing in a low-carbon Europe of 2050 and how to achieve transition. It begins with the contested links between wellbeing and material consumption. The study is a first, adopting interdisciplinary alternative perspectives rather than a unifying theory. These perspectives will be used to develop an original contribution, different visions of desired social wellbeing in the EU of 2050. The energy implications of social scenarios entailing lower material consumption are unknown, this study is original in quantifying their contribution. An innovation follows by backcasting transition through European policy towards scenarios of future wellbeing and reduced emissions. The proposed study is novel and highly innovative addressing priority gaps in knowledge. It dovetails important contributions to energy research and European society and policy with development of the researchers´ career and shared benefits for the host institution.

Keywords: wellbeing,consumption,scenarios,energy,low carbon
Radioactivity Monitoring in Ocean Ecosystems (RAMONES)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Greece,France,France,United Kingdom,Portugal
Call: Environmental Intelligence (H2020-FETPROACT-2020-2, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 3926093.75
EU funding (EUR): 3926093.75
Participants: 9
Project status: SIGNED

Natural radioactivity in the marine environment has been present since the Earth’s formation, while artificial radionuclides were introduced into the oceans in 1944. More recent direct sources exist that feed the oceans, such as low-level liquid discharges from reprocessing plants, large-scale releases due to disasters (e.g. Fukushima hit by the tsunami in 2011), and smaller-scale radiological events. Exploration of submarine environments should consider the existence of radioactivity in terms of its short- and long-term impact on marine and coastal ecosystems, also in correlation to natural hazards, such as seismic activity over submarine faults. Significantly undersampled in oceans, radioactivity poses real risks to marine ecosystems and human population, urging for detailed, data-driven modelling. RAMONES aims to offer new and efficient solutions for in situ, continuous, long-term monitoring of radioactivity in harsh subsea environments. A new generation of submarine radiation-sensing instruments, assisted by SoA robotic and artificial intelligence (AI) will be developed towards understanding radiation related risks near and far from coastal areas, while providing data towards shaping new policies and guidelines for environmental sustainability, economic growth and human health. The main ambition is to lay a radical new path to close the existing marine radioactivity under-sampling gap and foster new interdisciplinary research in threatened natural deep-sea ecosystems. RAMONES will invest a significant effort to provide tools for long-term, rapid deployments, propose new AI-driven and supported methodologies, and offer scaled-up solutions to researchers, policy makers and communities. RAMONES will combine SoA equipment from various disciplines and advanced modelling in fine synergy, and design new and effective approaches for the marine environment to provide efficient response to natural and man-made hazards, shaping future policies for the global population.

Keywords: radioactivity,remote sensing,environmental monitoring,marine geohazards,marine robotics,persistent autonomy,radioactivity modelling,dose assessment,health risk,environmental policy
Monetary Policy and Shadow banking: global micro-evidence from ABCPs (SHADOWBANKING)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

This project aims to contribute to a multi-disciplinary understanding of shadow banking and banks’ interactions with it, which includes accounting, banking and macroeconomics, with the purpose to assess their response to monetary policy changes. The financial crisis revealed how the banking system is both intertwined with, and exposed to, (systemic) risks in the shadow banking system. This latter is generally defined as “credit intermediation involving entities and activities outside the regulated banking system”, or non-bank credit intermediation. The complexity of the issue, the heterogeneous legal forms and accounting practice assumed has so far limited empirical research on these “de facto” banks and their activities outside the scope of the regulatory framework. Based on extensive rating agencies’ data, we examine how global shadow banking in the form of asset-backed commercial paper (ABCPs) – where the 2007- crisis started - are affected by monetary policy and can become a potential source of financial and banking instability because of their market-based funding. This research is innovative as it takes a global view of the shadow banking system by: i) focusing on the (lending)-activities of shadow banks, regardless of their legal forms and their reporting practices; ii) including US, but also EU and UK banks as major global players; iii) using micro data at ABCPs-portfolio level. After the crisis, this issue remains relevant in the current global uncertain economic environment and in the Euro Area as early-stage regulatory initiatives (FSB, BCBS) are aiming to transform shadow banking into a resilient market-based financing as an alternative to bank funding to support the recovery of real economy. The project addresses one of the focus areas in the agenda of Horizon 2020 in line with Europe’s main challenge to overcome the economic crisis: i) understanding the evolution of the crisis and ii) understanding the impact of global trends on the EU’s economy. ---

Keywords: shadow banking,monetary policy,asset backed commercial paper
Optimizing Support for Innovating SMEs (OaSIS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Germany,Spain,Belgium,Belgium,Croatia,Türkiye,Türkiye,Bulgaria,Türkiye,Poland,Czechia
Call: Innovating SMEs - segmentation along lifecycle and sectors (analytical research activity) (H2020-INNOSUP-03-07-08-2017, 2017)
Start date: 2017-12-15
End date: 2019-12-14
Duration (months): 24.0
Total project cost (EUR): 549750.0
EU funding (EUR): 549750.0
Participants: 13
Project status: CLOSED

The OaSIS project aims at improving the efficiency and effectiveness of the innovation support provided in European regions and strengthening the capacity of regional development agencies and other support providers. This goal will be achieved through the analysis of currently used approaches to the segmentation of innovating SMEs, description of the portfolio of innovation support measures used throughout Europe and the development of a new, performance-based methodology of SME segmentation, allowing for the precise targeting of innovating enterprises with support instruments best suited to their profile and enabling development of a new, hybrid innovation support schemes. Methodologies currently used by the innovation support providers for the "segmentation of the client base" and targeting the high-potential SMEs with the most ambitious projects are ineffective and not based on solid evidence. To improve the situation and increase the societal and economic impact from the innovation support we propose to gather a large dataset, containing historical information about support provided to SMEs by at least 15 different Regional Development Agencies from at least 10 different European regions. The performance of SMEs, in response to specific support measures will be assessed using carefully defined Key Performance Indicators and the big data analysis of the whole dataset will allow us to find correlations and similarities within the groups of SMEs that showed highest increase in performance after receiving specific support. Combination of the results with the analysis of the effectiveness of currently used approaches will be the basis for the formulation of the new, performance-based methodology of segmentation and practical tools, such as hybrid innovation support measures. The OaSIS project will significantly change the European innovation landscape and will provide a significant boost for European economy, as well as substantial societal impact.

Keywords: big data,data mining,regions,regional development agency,smes segmentation
COST - Maximising impact (SGA3)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: European Cooperation in Science and Technology
Action type: Specific Grant agreement
Countries involved: Belgium
Call: COST (H2020-SGA-SEWP-COST-2019, 2019)
Start date: 2019-05-01
End date: 2021-10-31
Duration (months): 30.0
Total project cost (EUR): 81840000.0
EU funding (EUR): 81840000.0
Participants: 1
Project status: CLOSED

Founded in 1971, COST is an intergovernmental framework for cooperation in science and technology (S&T). As defined in the COST Mission statement, COST provides networking opportunities for researchers and innovators in order to strengthen Europe’s capacity to address scientific, technological and societal challenges. To do so, COST funds bottom-up, excellence-driven, open and inclusive networks for peaceful purposes in all areas of science and technology. According to COST Vision statement, COST is aiming at becoming the leading open networking tool in the ERA. In order to continue to pursue its Mission and Vision, the COST Strategic Plan defines three strategic priorities for the remaining part of Horizon 2020 and in Horizon Europe: - Promoting and Spreading Excellence - Fostering interdisciplinary research for breakthrough science - Empowering and retaining young researchers and innovators To implement those strategic priorities, COST focuses its efforts on strengthening its core business and implementing a range of complementary activities. The COST Association is the beneficiary of a Coordination and Support Action (CSA) following the H2020 2019-20 Work Programme. The COST Association is an AISBL under the Belgian law with an integrated governance, management and implementation functions, creating the base for a responsible and accountable organisation where the COST Full Members have direct control. The legal and financial frame for the COST Association operations is provided via a Framework Partnership Agreement (FPA) and subsequent Specific Grant Agreements (SGAs). An overall indicative budget of EUR 300 million was foreseen for the duration of the FPA covering the total Horizon 2020 period. The proposal covers the second reporting period of SGA3.2 for a duration of months of 18 months, 1 May 2020 to 31 October 2021.

Keywords: networking,research and innovation,science and technology,knowledge sharing,interdisciplinary,openness,inclusiveness,bottom up,pan european cooperation,output oriented
The Emergence of a Science of Vegetation in Early Modern Natural Philosophy and the Sciences of Life: From Cesalpino to Malpighi (VegSciLif)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-15
End date: 2024-01-14
Duration (months): 36.0
Total project cost (EUR): 269002.56
EU funding (EUR): 269002.56
Participants: 2
Project status: SIGNED

This three-year research project aims to explore the emergence of a philosophy and science of plants in the century that goes from Cesalpino’s De plantis (1583) to Malpighi’s Anatome plantarum (1679), which influenced the development of a new science of life. Although understudied, a new approach to the study of plants and vegetation surfaces in this period, bridging the gulf between natural historical efforts to classify plants and natural philosophical investigations of vegetal bodies. By means of overlooked sources, the main objective of this project is to reconstruct these philosophical examinations through 4 sub-objectives: (1) the appropriation and reinterpretation of Aristotelian biology in botany; (2) the development of alchemical and mechanical frameworks to understand vegetal life; (3) the definition of plants as a crucial subject to reinterpret the physiology of living bodies; (4) the collecting attraction to plants diversity, and monstrosity, which preludes to the philosophical perception of interconnected systems of life, forestalling biodiversity. While new scholarly attention has been recently devoted to the philosophical study of plants in the early modern period, the result of this research project will be a broad investigation into the concept of vegetation and vegetal life that paved the way to eighteenth century morphologies and systems of nature. This project will result into several articles and a scholarly book for historians of knowledge. Dr Baldassarri has international experience in Germany, the Netherlands, Romania, and Israel, and has focused on the Cartesian understanding of plants and the mechanization of the vegetative soul. The development of this project will profoundly impact his career: training provided by Ca’ Foscari University in Venice and Bloomington Indiana University will help Baldassarri acquire new academic skills and boost his knowledge in connecting early modern science to contemporary biology and vegetal philosophy.

Keywords: early modern natural philosophy,early modern science of plants,vegetative soul,early modern vegetal anatomy and physiology,plants monstrosity,early modern biodiversity,life sciences,malpighi