Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
THERAPEUTIC ARCHITECTURE FOR CANCER: MIXED METHODS ANALYSIS OF BUILT ENVIRONMENT INFLUENCES ON OLDER PATIENTS’ WELLBEING IN CANCER OUTPATIENT INFUSION CLINICS (THERARC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2024-07-31
Duration (months): 36.0
Total project cost (EUR): 337400.64
EU funding (EUR): 337400.64
Participants: 1
Project status: TERMINATED

The proportion of the number of people aged 65 years and over compared to the younger population is steadily increasing in Europe. To accommodate growing healthcare needs, at least three European countries recently allocated a budget of €477 toward the building of new healthcare facilities. With age, the incidence of cancer greatly increases. Cancer is one of the primary causes of morbidity in Europe, with more than 3 million new cases yearly. Moreover, cancer patients’ experience of mental and physical fatigue, and anxiety is more pronounced due to the ageing process. Costly cancer medicine and research address the treatment of illness, yet the socio-spatial therapeutic qualities of cancer clinics, a fundamental aspect of health, remain an overlooked element of healthcare provision. Medical and architectural researchers recognize the therapeutic role of the built environment, yet primarily focus on patients’ needs in inpatient wards. Research in outpatient clinics has been scarce, even though the transient nature of outpatient clinics often fails to support fundamental socio-spatial needs such as privacy, territoriality and accessibility. Articulation of how the built environment of care, particularly outpatient cancer clinics, can support older patients’ wellbeing lacks interdisciplinary perspective. The scientific objectives of this project are a) exploration of the spatial elements that influence multifaceted needs of older cancer patients through ethnographic, quantitative research and gender analysis; b) the establishment of an interdisciplinary theoretical foundation based on medical sociology, environmental psychology and built environment studies. Articulating the spatial determinants of healthcare provision for the older population increases their survival rates and of other vulnerable groups with cognitive and physical impairment. This research addresses three Horizon 2020 challenges: inclusive society, wellbeing and health and resource efficiency.

Keywords: wellbeing,therapeutic environments,older patients,cancer,environmental psychology,user centered design research,user experience,medical architecture,healthcare environments
Deciphering the epigenetic components of the Shade Avoidance Syndrome in Arabidopsis (EpiShade)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-05-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Light limitation caused by vegetation proximity is an important threat to plant survival in natural and agricultural environments. In order to adapt the growth and development to high plant density communities, plants reacts with a set of responses named Shade Avoidance Syndrome (SAS). The objective of the current proposal is to investigate the transcriptional regulation of the SAS response by relating the activity of the transcription factor PIF7 (as a major SAS transcriptional regulator) with the chromatin status (particularly the transcriptional activator or repressor role of histone acetylation and methylation). The main goal of the EpiShade proposal is to elucidate if the chromatin landscape modulates PIF7 activity and/or PIF7 attracts the chromatin remodellers that leads to changes in the chromatin status. Since it seems likely that different PIF7 targets presents different regulation, the use of the genome-wide approaches included in EpiShade will be crucial. For the success of the proposal, EpiShade combines the expertise of the hosting group in the study of light response (phenotypic, biochemical, transcriptional) with that of the applicant in epigenetic marks profiling (combining chromatin immunoprecipitation and bioinformatics). To include the epigenetic level in the regulation of transcription is a novel approach and SAS an ideal model to address its complexity. The Marie Skłodowska-Curie fellowship will enable the candidate to develop his career improving his expertise in light response and to build an independent research program in Europe in the CRAG, a top-leading plant research centre.

Keywords: arabidopsis thaliana,shade avoidance,epigenetic marks,histone acetylation,polycomb group activity
Unleashing the potential of narrow leaf lupin as locally grown protein crop (UnleashLupin)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-02
End date: 2022-03-01
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Europe is in great need of a locally produced protein crop as it imports 70% of its protein requirements. Narrow-leafed lupin (Lupinus angustifolius, NLL) represents an excellent candidate. It is native to Europe, able to fix atmospheric nitrogen and produces high-protein grain (up to 40%). However, toxic alkaloids in the grain (quinolizidine alkaloids, QAs) prevent its widespread cultivation. Cultivars with low QA levels in all tissues are available; however, these are susceptible to herbivores, and grain QA content often surpasses safety thresholds. Interestingly, QAs are not produced in the grain, but are transported to the grain from vegetative tissues. Thus, I propose to specifically eliminate QAs from grain using a transport engineering approach without compromising defenses in vegetative tissues. In this UnleashLupin project I will discover and characterise the unknown transport proteins involved in translocating QAs to the grain. For this, I will combine my background in NLL genetics and genomics with the expertise of the Nour‒Eldin laboratory, which is world-leading in the field of plant specialised metabolite transport. Candidate genes will be selected from recently generated resources, and they will be tested for transport activity (e.g. in Xenopus oocytes) and cellular/sub-cellular localization. Techniques for in planta characterization (e.g. virus-induced gene silencing) will be provided by the Geu-Flores laboratory, which is currently investigating QA biosynthesis in NLL. The outcome will significantly advance the emerging field of long-distance transport of plant specialised metabolites. It will also be instrumental in the development of a locally grown high-value, herbivore-resistant NLL crop that accumulates little or no QAs in the grain but retains QAs in vegetative tissues. Such a crop has the potential of curbing the EU’s dependency on imported vegetable protein, thus contributing to sustainability and economic growth.

Keywords: transport engineering,anti nutritional compounds,crop improvement,pulse,secondary metabolites
Manipulating single fermions with light in cQED architectures (FERMIcQED)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1499133.0
EU funding (EUR): 1499133.0
Participants: 1
Project status: SIGNED

FERMIcQED aims at interfacing novel quantum materials with microwave light at the level of the single photon and fermion. To achieve this ambitious goal, I plan to use low-dimensional quantum conductors – such as carbon nanotubes or semiconducting nanowires – combined with state-of-the-art architectures and techniques of circuit Quantum Electrodynamics. The idea consists in isolating an individual fermionic degree of freedom within a hybrid Josephson junction – a quantum dot connected to two superconductors. Due to the superconducting proximity effect, entangled electron-hole states – called the Andreev bound states – form in the quantum dot and depend on the superconducting phase difference. By enclosing the hybrid Josephson junction inside a superconducting photonic cavity, one can couple these fermionic states to microwave light and probe their quantum properties in a well-controlled environment. Specifically, FERMIcQED will tackle three key experiments. First, we will detect the spin degree of freedom of the Andreev bound states and manipulate it coherently as a superconducting spin qubit. We will demonstrate strong coupling with cavity photons, which will enable quantum logic operations and long-range qubit interactions. Second, we will operate the hybrid Josephson junction in the topological regime in order to observe and manipulate Majorana fermions, thus implementing a topological qubit. At last, we will probe the joint entangled dynamics of bosonic and fermionic modes that coexist in hybrid Josephson junctions and simulate the spin-boson problem.

Keywords: hybrid quantum circuits
Holistic training of next generation Osteoarthritis researchers (OSTASKILLS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Netherlands
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2020, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 2169600.0
EU funding (EUR): 1084800.0
Participants: 1
Project status: SIGNED

Osteoarthritis (OA) is the single most common cause of disability in older adults and is expected to continue to grow in the decades to come. Despite the major socio-economic impact, OA patients are facing a staggering lack of disease-modifying therapies, leaving invasive total joint replacement as the only currently available option to treat end-stage OA. OSTASKILLS is based on a research programme aimed at the clinical development and market introduction of medical devices, pharmaceutical products and advanced therapy medicinal products for joint repair. OSTASKILLS aims at attracting ten talented doctoral candidates worldwide. It will issue two calls, inviting early stage researchers to apply for a doctoral training. The selection process OSTASKILLS has adopted is based on openness, transparency, merit, impartiality and equality for the applicants. The doctoral candidates will receive training through research and training by education. The main training objectives are: a variety of scientific methods within the field of regenerative medicine, as well as other transferable skills to improve the career perspectives of the doctoral candidates. OSTASKILLS aims to train the next generation of entrepreneurial scientists who are capable of combining and translating major innovations in life sciences towards meaningful clinical applications and the health care market. The field of joint preservation will act as a unique blueprint for the training of entrepreneurial scientists that can find their way towards other clinical application areas following their training in this programme. Every doctoral candidate will work in both an academic, as well as an non-academic partner organisation, to expose the young researchers to diverse research environments and equip them with the skills needed to bring innovations to actual implementation in practice.

Keywords: osteoarthritis,rheumatic diseases,translational research,cell therapy,regenerative therapy
AUTOCONFIGURABLE METROLOGICAL MEASUREMENT SYSTEM FOR PRODUCTION LINES IN AUTOMOBILE PIECES PROVIDERS (AUTOMET)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

WIP has detected that the companies engaged in the manufacture of metal assemblies for automobile, providers of a lot of parts to largest car manufacturers, have several problems in the measurement and calibration of its pieces, because much of this provision is the result of processes of stamping and welding. These processes are so aggressive that deform the components, causing a dimensional uncertainty gives rise to a problem unresolved: Many of the manufactured parts are large and have complicated geometries, therefore, it is impossible to measure them in the production line. Industrial measurement systems are generally large machines (coordinate system) located in temperature controlled laboratories. Current solutions are able to measure very few parts per time unit. These laboratories are typically used inspection of a part of each lot in a production, assuming that the assembly process is effective enough to not have to measure 100 % of them. But this is not this case, WIP has since found that this rule was valid in the past, but the specifications (tolerances) that automobile companies require to their suppliers (tolerances of tenths of a millimeter in large welding pieces), are destroying this measurement model. Producing a batch of defective pieces, with erroneous measurements, may result loss of entire batch, it would have to make the batch again (large stress in production line in the factory, the viability of the line is under doubts, etc) and this would involve a high cost. Moreover, confidence would be lost with the end customer. Therefore, due to these deficiencies in the measurement of pieces, WIP has identified a great business opportunity, especially in the field of automobile suppliers. WIP aims to apply to the SME Instrument for the large-scale commercialization of an AUTOCONFIGURABLE METROLOGICAL MEASUREMENT SYSTEM with a FAST SET-UP in any point of the production line, focused on the EUROPEAN AUTOMOBILE SUPPLIERS MARKET mainly: AUTOMET

Keywords: autoconfigurable metrological measurement system,fast set up,100,efficiency,advanced processing technologies,defective pieces,inspection
Science Unites ALL (SCI-ALL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Türkiye,Türkiye
Call: European Researchers' Night (H2020-MSCA-NIGHT-2016, 2016)
Start date: 2016-05-01
End date: 2017-10-31
Duration (months): 18.0
Total project cost (EUR): 162062.5
EU funding (EUR): 162062.5
Participants: 6
Project status: CLOSED

Europe has been witnessing a rapid increase of scientific developments, innovation and creation in the 21st century and transforming into one of the largest and leading scientific hubs of the world in terms of the scientific production and activities. However, the pace of science and technology production is not equally distributed all over the Europe and there are still serious gaps among countries concerning to the rate of scientific research and development activities. Moreover, all outcomes of this excellence and developments in science still cannot be instrumentalised enough to totally eliminate some serious social problems in the European societies. While this proposal pursues the general philosophy and goal of the European Researchers’ Night scheme as to provide a platform for bringing researchers and public together and motivate young people for a scientific career pathways, it also aims to emphasize on how scientific activities and developments can contribute for uniting European society at national and international level by raising awareness on the power of the science for social cohesion, dialogue and also individual development. Stemming from this general rationale, all activities of the “Science Unites All” (SCI-ALL) Researchers’ Night are constructed on the four main themes. These are: (i) Science unites generations, (elderly people, young people and all adult groups); (ii) science unites cultures; (iii) science unites genders; (iv) science unites stakeholders (research institutions and academia, research and development units of the companies, non-governmental organizations working on scientific development and social media settings that disseminate the scientific knowledge).

Keywords: science education,research,science awareness,science literacy,science unites generations,science unites cultures,science unites genders,science unites stakeholders
PRS, a disruptive technology for the industrial repair of large series of reusable plastic articles in the circular economy (PRS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In Europe, there are 1.8 billion items of plastic Returnable Transport Packaging (RTP), which are plastic pallets and crates that are used across various sectors, including the automotive, beverage, logistic and pooling services. Also in Europe, the number of plastic street containers for Municipal Solid Waste (MSW) exceeds ten million. The average lifetime of these articles ranges from five to ten years. When they break, these items are discarded and replaced with new ones. Discarded items have three destinations: recycling, incineration or as landfill. The owners of these plastic elements barely consider the possibility of their repair. At Plastic Repair System, we have developed and patented an industrial technology for the repair of reusable plastic articles, which allows their use with total confidence and guarantees, while the cost of repair is less than one third of the new value of the same article. Repairs undertaken with PRS technology have been analysed by independent laboratories that have certified that PRS recovers 100% of the object's functionality and at least 98% of its original strength. The industrialization of processes allows the systematic repair of large volumes of plastic articles, achieving significant cost savings for our customers, as well as environmental advantages. We estimate that our technology will help to reduce the carbon footprint in at least 0.89 Kg CO2 per Kg of repaired plastic item. After having successfully tested our technology on a small scale, we want to expand our Business Model internationally, starting with Europe. In fact, some customers with plants in several countries have asked us to extend our service to their plants in other countries. We have received also interest from two European venture capital funds focused in innovative companies in the circular economy. Phase 1 of SME Instrument represents an opportunity to improve our Business Plan for internationalization in a way that will allow us to minimize any risk

Keywords: reuse,plastic,repair,environment
Global drivers, local consequences: Tools for global change adaptation and sustainable development of industrial and cultural Arctic “hubs” (ArcticHubs)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Iceland,Iceland,Austria,Italy,Finland,Sweden,Sweden,Sweden,Norway,Finland,Norway,Norway,Norway,Russian Federation,Faroe Islands,Canada,Greenland,United Kingdom
Call: The changing cryosphere: uncertainties, risks and opportunities (H2020-LC-CLA-2019-2, 2019)
Start date: 2020-08-01
End date: 2024-07-31
Duration (months): 48.0
Total project cost (EUR): 5991083.75
EU funding (EUR): 5956083.75
Participants: 22
Project status: SIGNED

Increasing global competition for natural resources poses major challenges to the Arctic. ArcticHubs will develop sustainable solutions for reconciliation of competing livelihoods and land-use modes in key Arctic ‘hubs’—important socioeconomic nodes in a geographical network—and their surroundings, considering in particular the needs and cultures of local communities (incl. indigenous people). This will be achieved by applying multi- and interdisciplinary, multi-actor participatory approaches to systematically map, identify and analyse global drivers and pressures with high environmental, societal and economic impacts affecting 33 key hubs examining sustainability of fish farming, multiple use of forests, tourism, mining and indigenous cultures. The outcome of ArcticHubs will be the provision of solution-oriented tools, such as improved public participatory geographical information systems, guidelines for ‘social license to operate’, and future scenarios to Arctic communities, industrial stakeholders, decision- and policymakers, and other relevant actors. This will enable creation and implementation of regional development strategies that reconcile new economic opportunities with traditional livelihoods, and increase the resilience of both new and existing industries and livelihoods against environmental, economic and political changes in the Arctic. The impact of the project will be long-term sustainability and resilience of future environmental, socio-cultural, economic and political factors in the increasingly competitive and globalised Arctic, enhancing social acceptance of increased economic activity. These impacts will contribute to the implementation of the new integrated EU policy for the Arctic, IPPC assessments and other major regional and global initiatives, provide support to the EU Arctic Research Cluster, and enhance engagement of and interaction between local (incl. indigenous), national and global actors.

Keywords: participation,local communities,participatory gis,foresight,land use planning,fish farming,tourism,mining,forestry,indigenous culture,empowerment,globalisation,glocal,qualitative methods