Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Technology Of Protein delivery in Extracellular Vesicle-induced Cardiac Repair (TOP-EVICARE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-10-01
End date: 2025-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

More than 3.5 million people are newly diagnosed with heart failure every year in Europe with a long-term prognosis of 50% mortality within 4 years. There is a major need for more innovative, regenerative therapies that have the potential to change the course of disease. In the ERC-Extracellular Vesicle-Inspired CArdiac REpair (EVICARE), I hypothesized that we can recondition heart failure by stimulating cardiac repair with extracellular vesicles that are derived from progenitor cells. From the EVICARE application results, however, we realized that enhancing the therapeutic load of EVs will enhance their functional effect size to treat chronic diseases. In TOP-EVICARE (Technology Of Protein delivery in Extracellular Vesicle-induced Cardiac Repair), I aim to explore active loading and release systems that will allow protein therapeutic loading in extracellular vesicles to stimulate myocardial repair. Within this project, I aim to: I. Validate our innovative EV-loading strategy by assessing biodistribution and functional delivery in vivo, and exploring the potential for upscaling GMP production to meet industry standards and requirements; II. Conduct a comprehensive intellectual property (IP) landscape analysis to establish freedom-to-operate (FTO) and ensure that our technology can be commercialized without infringing on existing patents; III. Execute an in-depth market, competitor, and stakeholder analysis to identify strategic opportunities and potential challenges in the EV-based therapeutic landscape; and IV. Develop a robust and detailed business plan to effectively guide the commercialization of our loading technology, thus bringing a transformative solution to the treatment of various diseases.
Optimisation of digital catch monitoring and reporting in European Fisheries (OptiFish)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Innovation actions
Countries involved: Belgium,Spain,Croatia,Denmark,Greece,Netherlands,Türkiye,Norway
Call: Using automatic species recognition and artificial intelligence to fight illegal fish discards and revolutionise fisheries control (HORIZON-CL6-2023-FARM2FORK-01, 2023)
Start date: 2024-02-01
End date: 2028-01-31
Duration (months): 48.0
Total project cost (EUR): 5438952.5
EU funding (EUR): 4972602.5
Participants: 19
Project status: SIGNED

OptiFish will strive to provide technological solutions that will simultaneously improve the sustainability of fisher’s operations, enhance control processes and strengthen society’s trust in their products. OptiFish will develop, test and recommend a set of innovative technologies and tools supported by artificial intelligence (AI) to provide the management, the fishing sector and the scientist with data on catch volumes, catch compositions and the fishing environment. The goal is to unlock the full potential of technologies such as electronic and genetic monitoring for automated species recognition based on AI and computer vision to reduce discards, unreported landings and unreported fishing activities, ultimately establishing a fisheries control and enforcement system fit for the digital age. The technologies are not enough alone, it is also critical to consider the combination of technologies and the integration of computer vision models, the wide range of data sources and their subsequent formats, while also addressing stakeholders needs and acceptance. This goal cannot be achieved by a single project, which is why the aim of OptiFish is to lay a solid foundation for full technological development from which other projects and initiatives can be built. The project will place a strong focus on species recognition in different fisheries equipped with distinctly different catch handling facilities and in different European sea basins. To ensure that these innovations are relevant to fisheries management, OptiFish has participation from the Norwegian Directorate of Fisheries, and has received written support from the European Fisheries Control Agency (EFCA), the Basque, Danish and Belgian Fisheries authorities.

Keywords: em technology,dna,stakeholder engagement,data quality,standards,reporting and decision support tools,optifish academy,managers of the marine good,control agreement template
Multi-modal chemical probes as diagnostic tools (MULTIGLOW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: SIGNED

The overall goal of this project is the detection and imaging of the serine protease TMPRSS2. The first chemical part focuses on the design and synthesis of "multi-modal" chemical probes to visualise serine proteases, in particular TMPRSS2. The then obtained smart activity-based probes will be used to complete the goal of the biomedical part of the project, which is of TMPRSS2 in a mouse model for colorectal cancer (CRC) and in blood samples of CRC and prostate cancer patients. Successful execution will lead to new diagnostic tools to detect TMPRSS2. The chemical tools will be readily applicable to other serine proteases as well, whereas the specific TMPRSS2 probes may also be used in other cancer types.

Keywords: activity based probes,serine proteases,chemiluminescence,colorectal cancer,prostate cancer
CELLULOSE-BASED MULCH FILMS WITH NATURE-INSPIRED WATER-MANAGEMENT STRUCTURES FOR AGRICULTURAL APPLICATIONS (CELLAGRI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Germany,Belgium,France,Sweden,Slovenia,Spain,Switzerland
Call: Nature inspired alternatives for food packaging and films for agriculture (HORIZON-EIC-2024-PATHFINDERCHALLENGES-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 4353512.61
EU funding (EUR): 3965307.25
Participants: 9
Project status: SIGNED

The main idea of the project relies on cellulose-based films featuring passive water management by microfluidic structures. The base material is biobased, biodegradable, and broadly available. Unfortunately, the mechanical properties (tear resistance, stretchability, penetration stability) are not sufficient for agricultural applications. Moreover, in horticulture, cellulose is prone to the formation of fungi and mould. These drawbacks will be overcome by combination of different cellulose types like plant-based cellulose, regenerated cellulose and bacterial cellulose. Additional coatings will be applied that partly immerse the film. Such coatings will be modified in view of its surface structure to achieve water management or avoid mold formation in horticulture. This will be done using imprint technologies in combination with coating technologies. Such nano- or micro-imprint technologies are known to be used for high-end applications like generating lab-on-chip devices for medical applications. A new approach will be investigated using electron beam curing technologies to validate such structuring method in low-cost applications like mulch films utilizing high-speed capabilities of e-beam curing processes. The water management will be nature-inspired mimic e.g. leaf structures. Using atmospheric plasma technologies hydrophobicity and hydrophilicity of structures will be optimized by changes in surface chemistry. Tuning the surface properties will also have an important impact on biodegradability. The goal is to develop a toolbox that allows to use the novel mulch materials for a variety of applications in agriculture and horticulture and at different climate conditions. Development targets TRL 5 by validating at real field tests. Nevertheless, all different technological building blocks will be scaleable to roll-to-roll production, ensuring high productivity and allowing low-cost products in the future.

Keywords: mulch film,microfluidic structures,bacterial cellulose,plasma treatment
Enzyme-Mediated Dynamic Combinatorial Chemistry (ENZYME-DCC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 1499997.0
EU funding (EUR): 1499993.0
Participants: 1
Project status: SIGNED

Biomolecular templates define the outcomes of enzymatic reactions in some of the most fundamental of biological processes, such as DNA replication, transcription and translation. In synthetic chemistry, molecular templates have enabled the synthesis of highly complex molecular architectures and interlocked structures. The possibility to use synthetic templates to direct enzymatic reactions and obtain alternative products to those generated in Nature will be investigated in this project. The overall objective of this research programme is to explore a conceptually new approach to the use of enzymes for chemical synthesis and thus establish a new synthetic methodology - Template-Directed Enzyme-Mediated Dynamic Combinatorial Chemistry. We will exploit the inherent reversibility of enzymatic reactions to generate dynamic chemical networks, which can be manipulated via supramolecular interactions with artificial template molecules to promote the preferential synthesis of specific products. To implement this novel concept, we will develop an unprecedented, templated, enzymatic approach to oligosaccharide synthesis. We will explore dynamic systems of interconverting glycans with the goal of accessing unusual or challenging oligosaccharide products. The specific aims are: 1. To achieve templated enzymatic selective synthesis of large-ring cyclodextrins (cyclodextrins (CDs) with more than 8 glucose units). 2. To explore cyclodextrin glucanotransferase-mediated dynamic mixtures of modified CDs, and, using thiol-functionalised CDs, develop a doubly dynamic system that combines reversible transglycosylation with disulfide exchange. 3. To generate phosphorylase-mediated dynamic mixtures of linear α-1,4-glycans and employ templates to achieve length- and sequence-selective synthesis. 4. To establish a fuelled far-from-equilibrium system for continuous large-ring CD synthesis using templates together with a series of interconnected dynamic enzymatic transformations.

Keywords: dynamic covalent chemistry,systems chemistry,enzymology,carbohydrates
Large-scale subcellular ensemble dynamics in the mouse brain revealed by adaptive optics two-photon mesoscopy (AdaM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 2
Project status: SIGNED

Higher brain functions, such as decision-making, are associated with the coordinated activity of multiple cellular structures (e.g., cell bodies and cellular processes of neuronal and non neuronal cells) distributed over multiple brain areas. Recent technical developments enable monitoring this ensemble activity across different brain regions with high (i.e., cellular and subcellular) resolution using large field-of-view (FOV) two-photon (2P) mesoscopy. However, optical aberrations mostly due to light scattering strongly limit the application of these technologies when the imaging depth within the brain increases. To address this limitation, I will here design, develop, and validate the first adaptive optics (AO) mesoscope, combining the strength of adaptive aberration correction with the power of large FOV 2P mesoscopy. I will first benchmark this novel approach to image ensemble Ca2+ dynamics of small brain structures (e.g., processes of neuronal and non-neuronal cells) in living mice over large FOV and at increasing imaging depths. I will then focus on recording Ca2+ signals from processes of astrocytes, the main non-neuronal cell type in the brain, which play fundamental roles in brain physiology. I will study how networks of thin astrocytic structures encode behavioural information over multiple cortical regions during a decision- making task. Finally, I will apply analytical methods based on information theory and machine learning to extract emergent properties of distributed ensembles and their correlation with behaviour. In conclusion, I will combine expertise in optical engineering, neuroscience, and computation to reveal the functional dynamics of the fine cellular structures across multiple cortical areas. This project will allow extracting details about ensemble dynamics that have long remained inaccessible, contributing to elucidate the contribution of coordinated activity of cellular and subcellular structures to higher brain function and behaviour.

Keywords: adaptive optics,two photon random access microscopy,calcium imaging,sub cellular resolution,astrocytes,l5 neurons,somatosensory cortex,motor cortex,information theory,machine learning
Open source deep learning platform dedicated to Embedded hardware and Europe (NEUROKIT2E)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Research and Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: France,Netherlands,Austria,Italy,Germany
Call: General according to ECS-SRIA 2022 (RIA) (HORIZON-KDT-JU-2022-2-RIA, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 19423471.66
EU funding (EUR): 6203293.72
Participants: 27
Project status: SIGNED

The NEUROKIT2E project aims at proposing a Deep Learning Platform for Embedded Hardware around an established European value chain (providing AI hardware and software). This open-source platform will provide the necessary tools for Europe to play on the same level with its American and Chinese competitors, and take the lead on a competitive aspect (still underdeveloped but which will quickly prove to be essential): embedded AI. The NEUROKIT2E’s offer targets to serve European industry needs as a priority, enabling easy and fast Neural Network design, optimization and implementation on constrained hardware targets. This challenging development will be powered using N2D2 (for Neural Network Design & Deployment) platform, developed by CEA, Coordinator of NEUROKIT2E, for the exploration and development of AI applications, and embed specific hardware components from European players such as NANOXPLORE, STMICRO, , all members of the NEUROKIT2E consortium. NEUROKIT2E will provide essential outcomes such as the end of the dependence of EU stakeholders to American and Chinese tools, the valorisation of EU hardware technologies, the benchmark of hardware and architectures before implementation to ensure the success of embedded AI in devices from energy consumption to sparse resources exploitation, the capacity to overcome the heterogeneity of components through a single, open, sovereign platform while ensuring reliability, safety, transparency. The NEUROKIT2E framework will impact on the AI landscape as the first one dedicated to embedded AI and will position EU stakeholders in this key market. The NEUROKIT2E consortium relies on 5 EU countries active in the hardware and software activities, France, Netherlands, Austria, Germany and Italy, with a balance between private and public research: 13 private companies (4 large industries: THALES, IFAG, TTTECH AUTO AG, STMICRO; 9 SMEs: NANOEXPLORE, KOMPAI ROBOTICS, Almende, Spiki, Deepsensing, HTS, Sensity, CODA, Sorama) ; 5 RTOs (CEA, IMEC-NL, SAL, FBK, Fraunhofer) and 6 universities (FH-CAMPUS WIEN, TUD, UNICT, UNIPA, UNIME, UROS ).

Keywords: artificial intelligence,embedded software,ai framework,process technology,edge computing,digital industry,aiot,processors and accelerator
The map of Redox Intracellular Signaling in skin physiology (redOXFluxMAP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

The skin is the widest organ of the human body. Despite this, the mechanisms that underline its regulation are relatively poorly understood. Many skin diseases are characterized by defects in the control of lining renewal or reestablishing barrier integrity after the disruption. Thus, dissecting the signals that underpin the maintenance of skin homeostasis and regeneration are of pivotal interest for medicine. Recently, redox signaling as described to have a crucial role in these processes: indeed, H2O2 -the major signaling molecule of redox biology- is not only an essential second messenger, involved in skin proliferative and survival pathways but also it is reported that mild ER stress cursing with an increase in organelle redox potential is needed for efficient reepithelization. Recently, we have shown the presence of different ER-linked H2O2 fluxes that orchestrate cellular redox responses in normal conditions and after the induction of ER stress in HeLa cell lines. In this scenario, I propose to unveil the compartment-specific H2O2 fluxes that regulate the redoxstasis during keratinocytes differentiation with particular emphasis on those that arrive from the Endoplasmic Reticulum (ER). Indeed, the ER is one of the major contributors to cellular redoxstasis harboring sources, internal regulators, and distributors that vehicle redox signals back and forth to the ER. In particular, I divide this project into two main aims I) Characterize the role of intracellular redox fluxes during keratinocytes differentiation both in 2D and in 3D models II) Identify the interactors of ER-derived H2O2 flux in skin cell lines and characterize the downstream pathways. Importantly, a systematic analysis of the timing, thresholds, and targets of redox signals in skin pathways is a paramount gap in the field that has not yet been tackled, and thus constitutes the principal aim that this project wants to undertake.

Keywords: skin,redox signaling,h2o2,flux,differentiation
On-chip energy harvesting and management enabled by Thermal engineering of two-dimensional MAterials (TheMA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Greece,United Kingdom
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-02-01
End date: 2029-01-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: SIGNED

Two-dimensional (2D) van der Waals layered materials have been acclaimed for their great potential in several fields of condensed matter physics. As applications are starting to appear, increased effort is dedicated to understand their unique electronic, optical, mechanical and chemical properties. However, thermal and thermoelectric (TE) properties of 2D materials remain largely underexplored despite their profound potential impact on one of the most important current scientific and technological challenges: energy management. TheMA is an ambitious project, which aims to create a breakthrough in our understanding and ability to control phonon and energy transport at the nanoscale. Its main goal is to create novel 2D semiconductor nanomaterials and heterostructures for thermal management applications and TE devices for power generation beyond current state-of-the-art. Specifically, by using phonon engineering approaches supported by advanced characterization, the project targets the fabrication and on-chip integration of (a) novel engineered transition metal dichalcogenide (TMD) based nanostructures for heat guiding and superior thermal insulation and (b) TE power generators capable of recycling the waste heat from hot spots or environmental interlinks, to deliver sufficient power to sustain low-power electronics. Ultimate goal of the project is to provide innovative solutions for on-chip energy management and energy harvesting for Information and Communication Technologies, the Internet of Things and 2D nanoelectronic devices. The research proposed here will go beyond state-of-the-art providing the in-depth understanding of nanoscale energy dissipation and phonon transport in 2D nanomaterials and lay the foundations for the development of future three-dimensional heterogeneous electronics. The findings will drastically enhance the prospects of TMD materials for thermal management and TE applications and boost their integration in the main semiconductor industry.

Keywords: 2d materials,phonons,energy transport,thermal management,thermoelectric power generation,phonon engineering