Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Blue Bunkering of Anchored ships with Renewable Generated Electricity (BlueBARGE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Innovation actions
Partnership: ZEWT (co-programmed)
Countries involved: Greece,Spain,Norway,Denmark,Türkiye,Netherlands,Portugal,Cyprus,Austria,Italy
Call: Developing a flexible offshore supply of zero emission auxiliary power for ships moored or anchored at sea deployable before 2030 (ZEWT Partnership) (HORIZON-CL5-2023-D5-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 11334100.0
EU funding (EUR): 8498001.25
Participants: 15
Project status: SIGNED

The shipping industry is responsible for around 3% of global greenhouse gas emissions, and this is expected to increase as global trade and shipping activity continues to grow. As such, reducing emissions from shipping is an important part of global efforts to tackle climate change. In recent years, policies and legislation, mainly focusing on environmental sustainability, have pushed international shipping toward the process of its decarbonization. Regulatory bodies are pressing on the maritime world by adopting ambitious targets and by introducing a number of initiatives that will facilitate the transition to a sustainable future, including the International Maritime Organization's strategy to reduce greenhouse gas emissions from shipping, which aims to halve emissions from the sector by 2050 compared to 2008 levels. To this end, BlueBARGE will design, develop and demonstrate an optimum power-barge solution to mainly support offshore power supply to moored and anchored vessels, limiting local polluting emissions and global GHG footprint in a life cycle perspective, following a modular, scalable, adaptable and flexible design approach which will facilitate its commercialisation by 2030. The proposed power-barge solution will consider different alternatives as containerised power supply modules in a variety of configurations, where battery modules will serve as basis due to their high energy efficiency and readiness level, and other considered modules including hydrogen fuel cells and hydrogen generators. The project will address electrical integration issues, interfacing challenges of the barge with ships, ports and local grid, operational safety and regulatory compliance aspects, delivering a high-readiness and complete “power bunkering” solution. Overall, the BlueBARGE project’s full integrated system aims at contributing to the shift of the maritime industry towards the goals of electrification and decarbonisation at an EU and international level.

Keywords: electrification anchoring ships power supply anchorage power barge ops offshore power supply onshore power supply
Bidirectional remote deep brain control with magnetic anisotropic nanomaterials (BRAINMASTER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The emergence of a new era in neuromodulation is led by the intriguing potential of functional materials to replace or control neural activity. The ability to simultaneously analyse neural activity offers the potential to translate signals into a feedback loop for intuitive therapy or even to replace lost neurological functions. However, neuromodulation and recording in the deep brain commonly relies on chronic implantation of macroscale hardware with numerous safety concerns and often suffers from poor spatiotemporal resolution. BRAINMASTER will demonstrate scalable, wireless, minimally invasive neuromodulation relying on forces transformed to mechanosensory neurons by magnetic nanodiscs (MNDs) coupled to external magnetic fields (MFs). Neuromodulation will run concurrently with magnetic resonance imaging (MRI) of Ca2+ transients. BRAINMASTER’s ambitious objectives will permit cell-type specific interrogation (write) and simultaneous imaging (read) of deep brain in untethered subjects without implanted hardware, overcoming major challenges present in existing approaches. MNDs will be engineered to selectively target neural mechanosensitive ion channels by release of viral vectors for exogenous channel expression or by recognition motifs for endogenous stimulation. MND surface with Ca2+ binding moieties will allow dynamic MRI imaging via formation of ferromagnetic clusters translated as MRI contrast variations. The bidirectional BRAINMASTER interface will include MRI Ca2+ imaging simultaneous with stimulus from large gradient forces ‘pulling’ MNDs on mechanosensory cells and torques mediated by low frequency MFs from miniaturized, MRI compatible coils. Ultimately, I will develop the first-of-its-kind intuitive interface between the deep brain and an engineered system to facilitate cognitive training and therapies for developmental, neurodegenerative and mental disorders and demonstrate the technological breakthrough in the rodent model of early Alzheimer’s disease.

Keywords: neural interfaces,wireless neuromodulation,advanced functional nanomaterials
Pneumonia induced trained immunity as a driver of pathogenic inflammation within the lung (Trained_Lung)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-15
End date: 2026-10-14
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

The world health organisation has labeled inflammatory diseases the greatest threat to human health. Inflammation is a major cause of pathogenesis in respiratory conditions such as bronchiectasis, ARDS, and COPD. There is a growing appreciation that our prior pathogen exposure can induce trained immunity in macrophages. Trained_Lung will explore how bacterial pneumonia induces central trained immunity and how this can lead to excessive inflammation and lung damage, in response to other bacteria or environmental pollutants. Recently it has been shown that repeat exposure to influenza can lead to lung damage due to the altered functionality of lung macrophages, leading to excessive inflammation and damage to the structure of the lung. However, it remains unclear if this is the case for bacterial pneumonia and if it can lead to inappropriate inflammatory response upon rechallenge with other bacterial species or environmental pollutants. I propose that bacterial pneumonia will drive enhanced myelopoiesis and enhance circulating monocyte inflammatory responses. Further, these circulating monocytes will replace resident alveolar macrophage populations over time, seeding the lung with these trained monocytes which will become resident alveolar macrophages. Alveolar macrophages are constantly in contact with a range of bacteria, viruses, PAMPs, and pollutants which all have the potential to drive excessive inflammatory responses. Trained_Lung will identify pathogens that can train human macrophages and examine secondary inflammatory responses to a range of bacterial pathogens and environmental pollutants. Further, myelopoietic changes in the bone marrow and functional changes in macrophages post-pneumonia in mice will be explored, and how these changes impact subsequent challenges in terms of lung function and damage. Finally, Trained_Lung will explore how trained macrophages impact immune responses within iPSC-derived human lung organoids, adding a key translational aspect

Keywords: trained immunity,pneumonia
Smart roots for reducing greenhouse gases emissions from rice cropping (SmartRoots)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-15
End date: 2025-01-14
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 2
Project status: CLOSED

Rice production is the main agricultural source of greenhouse gases (i.e., carbon dioxide; CO2, nitrous oxide; N2O and methane; CH4). Scientific evidence suggest that greenhouse gases (GHGs) produced and accumulated in rice paddies (flooded soils) can be vented out to atmosphere through plant tissues. However, information on the plant characteristics influencing such GHGs emission processes is scarce. The mechanisms of GHGs diffusion from rhizosphere to and along the roots and the vent of these GHGs to atmosphere as well as the permeability coefficient of roots to GHGs are largely unknown. This project aims to identify characteristics of rice roots that reduce both the vent of GHGs through plant tissues from soils to atmosphere (through root apoplastic barriers) and the production of GHGs in soils (oxidation of CH4 to CO2). Moreover, this project will study the root permeability to GHGs and the anatomical and chemical characteristics contributing to GHGs diffusion through plants. This project will use a multidisciplinary approach combining state-of-the-art physiological measurements including microsensing technology (for in vivo gas fluxes), gas chromatography, mass spectrometry and microscopy characterization of plant tissues. It is hypothesized that genotypes with tight barriers to radial oxygen loss will have less permeability to GHGs. Moreover, genotypes with no barriers to radial oxygen loss, high number of laterals and an efficient roots system for O2 transport will allow high CH4 oxidation to CO2, thus reducing the venting of this potent GHG to atmosphere. This project will identify root phenotypic differences among rice cultivars and this will serve as a basis for developing high yielding cultivars with desirable traits reducing GHGs emissions from flooded soils.

Keywords: greenhouse gases,climate change,rice,flooding,radial oxygen loss,apoplastic barriers,microsensors,root permeability
Glycan-coated Protein(oid) Nanocarriers for the Delivery and Controlled Release of Anticancer Agents (PRONACORE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Hungary
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 157622.4
EU funding (EUR): 157622.4
Participants: 1
Project status: SIGNED

Cancer is a leading cause of death in the EU and worldwide. Chemotherapy has high risks and severe side effects due to the poor bioavailability of anticancer drugs. The inefficiency of current formulation vehicles necessitates better carrier systems. Proteins, as non-toxic, biodegradable natural polymers capable of self-assembly, seem especially promising as nanocarriers to encapsulate anticancer agents. Plasma-derived protein excipients are expensive and increase the risk of infection. The use of plant proteins, however, is limited by their immunogenicity. The main ambition of PRONACORE is to develop new, safe and sustainable, glycan-coated protein(oid) nanocarriers with reduced immunogenicity for the oral, subcutaneous, and intravenous delivery of poorly soluble anticancer agents. By a top-down approach, core-shell type corn protein hydrolysate-pectin nanocarriers will be developed, demonstrating also a high-value route for the valorisation of sugar beet pectin. In parallel, we apply a bottom-up approach to design and synthesize glycosylated proteinoid nanocarriers, tailored to the cargo compound by the careful selection of building blocks assisted by molecular dynamics tools. IP protection will be sought for the methods invented. The feasibility of the developed nanocarriers for parenteral delivery will be determined. Our study on self-assembly and the factors determining the immunogenicity of protein(oid) nanocarriers will be made widely available to the scientific community, end-users, and the public. The concept builds on Researcher’s previous experience, incorporates new elements, and creates the opportunity to initiate further research and innovation. He intends to remain active in this field beyond the scope of the MSCA fellowship to set up his own research group at the host, securing funding from national and EU grants and building a consortium for the development of sustainable soft materials for food, cosmetics, pharma-, and nutraceutical applications.
Electrochemical stereoselective radical cascades for accessing natural-like compounds (ELECTRO-ASYMMETRIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 3
Project status: CLOSED

Identifying successful lead drug candidates is a significant and current challenge to society. The ELECTRO-ASYMMETRIC project seeks to provide some solutions through assisting the development of more effective drug discovery technologies. Specifically, we aim to use electricity-driven organocatalytic cascade processes for the stereocontrolled synthesis of chiral lactones and polyfunctionalized heterocycles, which are common motifs in biologically active molecules. Asymmetric organocatalysis and electrochemistry, two powerful strategies of modern chemical research, have extraordinary potential for sustainably preparing the novel organic molecules required for driving innovation in the pharmaceutical industries. However, the control of enantioselectivity in electrochemical radical processes poses a fundamental scientific challenge. ELECTRO-ASYMMETRIC asks whether asymmetric organocatalytic electrochemical cascades could be an effective tool for rapidly synthesising novel chiral nature-inspired building blocks with high stereocontrol. The chiral molecules prepared in this project will be screened for biological activity in a multidisciplinary collaboration with Janssen, increasing the probability of success in identifying successful drug candidates. This fellowship brings a new industrial collaboration to the host institution, and transfers expertise of advanced techniques in asymmetric catalysis to the candidate and knowledge of electrochemistry to the host group. The project’s multidisciplinarity and intersectoral nature will broaden the fellow’s competencies and will place him in a competitive position for his next career move.

Keywords: radical chemistry,asymmetric catalysis,organocatalysis,electrochemistry,electron transfer,drug development
Data Aware efficient models of the urbaN microclimaTE (DANTE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 1450560.0
EU funding (EUR): 1450560.0
Participants: 2
Project status: SIGNED

The share of the world’s population living in cities is rapidly increasing, and it is expected to rise to 80% by 2050. It is therefore crucial to develop new efficient and reliable methods to model the urban microclimate; in fact, these models can support urban planners and policymakers to create more comfortable and sustainable cities. High computational requirements limit existing numerical methodologies, and DANTE fits in this context and aims to create a new paradigm for fast and reliable numerical simulations bridging the fields of model order reduction, machine learning, and data assimilation. The idea is to create a research team to answer many unresolved questions in model order reduction for complex and real-life urban microclimate simulations. Particular emphasis will be given to advanced machine learning tools, which incorporate physics knowledge, aiming to improve the accuracy, interpretability, and reliability of predictive models. The identified tasks cover a wide range of different topics: dimensionality reduction of the solution manifold in problems governed by complex physical principles, uncertainty quantification, data assimilation, and inverse modeling. The new tools will have the agility of data-driven methods in complex nonlinear settings and the physical rigor of projection-based methods with quantified errors. The developed methods will significantly impact digital transformation, enabling digital twins of urban environments. Possible applications include, but are not limited to, urban air pollution, heat island modeling, wind loads on buildings, and inverse modeling approaches.

Keywords: reduced order modelling,scientific machine learning,digital twins,autoencoder,nonlinear model order reduction,computational mechanics,uncertainty quantification,urban microclimate
Embodying Pain: Chinese Women Writers’ Articulations and Memories of Mao-Era Suffering (EMBODIMENT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Estonia
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-15
End date: 2027-07-14
Duration (months): 24.0
Total project cost (EUR): 189905.52
EU funding (EUR): 189905.52
Participants: 1
Project status: SIGNED

This project explores Chinese women writers’ articulations and recollections of pain from the 1950s through the 1980s. The focus is on heretofore neglected or understudied life writing by women who had become established cultural workers before the founding of the People’s Republic of China in 1949, and had witnessed or suffered punishment in the mid- or late 1950s. Mei Zhi’s (1914-2004) account of her husband Hu Feng’s political exile in Sichuan and Ding Ling’s (1904-1986) memories of her experience at a labor camp in Beidahuang, Manchuria, are a few examples of women writers’ personal narratives of Mao-era suffering, and among the key texts that this project intends to analyze. Traditionally marginalized within Chinese literary histories and canons, these texts offer a unique entry point into how Chinese women have brought life writing to bear on experiences of suffering. Drawing on literary and gender studies, memory theories, pain studies, and histories of emotions, senses, and experience, this project highlights the potential of these texts for rethinking the place of the female body in life writing that stems from or evokes authoritarian and disciplinary contexts. In historicizing these women writers’ embodied articulations and recollections of pain, this project adopts an interdisciplinary methodology centered on the notion of affective experience to reveal the dynamic relationship between context, lived experience, and writing. This relational model will draw attention to women’s creative strategies of negotiation and survival from within the system, beyond clear-cut divisions between compliance and resistance under duress. Finally, by attending to a wide range of emotions and solidarities that can grow out of pain situations, this project will unravel the therapeutic potential and the limits of life writing, with far-reaching implications in the interdisciplinary fields of gender studies, pain studies, and medical humanities, as well as in society at large.

Keywords: chinese literature life writing pain
Arousal and respiratory co-dysfunction in drug-resistant epilepsy: from mechanisms to therapy (EPIAROUSAL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 1994315.0
EU funding (EUR): 1994315.0
Participants: 2
Project status: SIGNED

Both seizures and their complications are modulated by patients’ vigilance states. Several epilepsy complications are associated with sleep, including Sudden and Unexpected Death in Epilepsy (SUDEP). SUDEP primarily results from a fatal postictal central apnea after a nocturnal generalized convulsive seizures. While transient seizure-related respiratory dysfunction is frequent in patients, current hypotheses suggest that in some of them, repetition of seizures may induce a chronic alteration of respiratory regulation, increasing the risk of fatal apnea. Reducing the severity of postictal respiratory dysfunction has thus appeared as one of the most promising way to prevent SUDEP. However, no encouraging result has been reported yet, suggesting that epilepsy-related respiratory dysfunction may only be the tip of the iceberg. Given the numerous interconnections between the network that regulates arousal and sleep and the respiratory network, I make the hypothesis that some patients with drug-resistant epilepsy might combine this well-known seizure-related respiratory dysfunction with a chronic alteration of arousal regulation, resulting in abnormal asphyxia-induced arousal. Adenosine system is deeply implicated in the regulation of sleep and central respiratory control and is modulated by seizures. Epilepsy-related alteration of the brainstem adenosine pathway may play a key role in the development of arousal and respiratory co-dysfunction. Using both experimental and clinical studies, EPIAROUSAL will investigate the exact interplay between epilepsy-related respiratory dysfunction and arousal regulation on the one hand, and the relation between long-term repetition of seizures, brainstem adenosine pathway and the respiratory and arousal co-dysfunction on the other hand. The final objective is to validate that adenosine-targeted therapy can restore normal asphyxia-induced arousal in drug-resistant epilepsy, paving the way for a first a clinical trial of SUDEP prevention

Keywords: epilepsy,sudep,adenosine