Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Solutions for outdoor climate adaptation (SOLOCLIM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Germany,Italy,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-10-01
End date: 2023-09-30
Duration (months): 48.0
Total project cost (EUR): 1626994.8
EU funding (EUR): 1626994.8
Participants: 7
Project status: SIGNED

The aim of SOLOCLIM is to develop a doctoral training programme that enables young researchers to generate solutions for urban outdoor. The aim of SOLOCLIM is to develop a doctoral training programme that enables young researchers to generate solutions for urban outdoor environments. Projections show that urbanisation could add another 2.5 billion people to urban areas by 2050 and the cumulative effect of all the negative urban climate impacts of urbanisation such as the occurrence of urban heat islands as well as distinctive wind patterns in cities create discomfort and health risks. As climate change will exacerbate these urban and microclimatic problems citizens need to be protected. As cities create their own climates, the solutions to these problems are to be found in the (re-)design of cities. Some solutions are known such as the use of vegetation, but there are still many remaining questions about the impact of vertical green as well as the proper distribution of green in cities to have an optimal effect. Moreover, upcoming systems using water vapour as a coolant as well as flexible systems that respond to microclimate have not been studied yet. SOLOCLIM will develop such solutions on different scale levels from small scale around buildings to a larger neighbourhood/city scale and test their effects. The industry in architecture, urban and landscape design is in need of these innovative solutions as climate adaptation in cities is one of the largest challenges for the future. All plans and designs that the industry develops have to respond to the urban (micro)climate challenges. Apart from the availability of solutions the industry also needs the expertise. This expertise involves design and research skills related to urban (micro)climate. SOLOCLIM trains experts in this field and offers a training for advanced climate responsive design that will be offered to the PhD students as well as some parts to a broader community and beyond the duration of SOLOCLIM.

Keywords: urban climate,microclimate,urban design,landscape architecture,facade design,building materials,vegetation
Therapeutic potential of optimized derivatives of an endogenous CXCR4 antagonist for the treatment of cancers and inflammatory diseases (EPI-X4Health)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany,Germany,France
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-09-01
End date: 2020-02-29
Duration (months): 18.0
Total project cost (EUR): 149156.0
EU funding (EUR): 95256.0
Participants: 3
Project status: CLOSED

Deregulation of CXCL12 signaling via the CXCR4 chemokine receptor plays a key role in many diseases, including cancer, rheumatoid arthritis, chronic inflammation and cardiovascular disorders. Thus, agents modulating CXCR4 signaling offer many prospects for therapeutic development. CXCR4 is also a major coreceptor for HIV entry. Thus, we used HIV as tool to screen peptide libraries encompassing the entire blood peptidome for novel CXCR4 ligands. This approach allowed the identification of a small fragment of human serum albumin as potent HIV inhibitor. Remarkably, this naturally occurring peptide, named EPI-X4 (Endogenous Peptide Inhibitor of CXCR4), blocks CXCL12/CXCR4 signaling and suppresses cancer cell migration and invasion. Preclinical studies in mice show that EPI-X4 mobilizes hematopoietic stem/progenitor cells and inhibits lung inflammation in an asthma model. Preliminary analyses suggest that EPI-X4 is more specific and better tolerated than Mozobiol® (AMD3100), the only CXCR4 antagonist approved for clinical application. Recently, we developed synthetic derivatives of EPI-X4 showing about three orders of magnitude improved potency against HIV as well as increased plasma stability. Key goals of this project are to determine the therapeutic potential of these improved derivatives against cancers (Aim 1) and inflammatory diseases (Aim 2) using established mouse models of colon carcinoma, osteosarcoma, glioblastoma, airway inflammation and dermatitis. These disorders were selected from the large number of CXCR4-linked diseases because no safe and effective treatment exists and since preclinical mouse models are available to determine whether EPI-X4 derived agents are more efficient and better tolerated than other compounds. In parallel to the experimental assessment of the therapeutic potential of these novel CXCR4 antagonists, we will perform market analyses and develop an IPR strategy to pave the way towards commercialization and future clinical application.

Keywords: g protein coupled receptors,chemokines,cxcr4 signaling,antagonist,colon carcinoma,osteosarcoma,glioblastoma,inflammation,allergy,endogenous peptides,peptide optimization,mouse models
MAGIC-SWITCH: Magnetic Switch Controlled with Voltage (MAGIC-SWITCH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-12-01
End date: 2021-05-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

We are living in a world that is increasingly driven by data. Governments, healthcare facilities, commercial businesses and individuals are all storing information in electronic form. This has led to the emergence of digital and cloud-based technologies. The ability to use information more efficiently has resulted in a rapid increase of the value of information. However, with the Big Data revolution, information is facing new challenges. Energy efficiency during writing of magnetic information needs to be improved. Thus, enhancing robustness in data storage systems is one of the major challenges in our modern society. Our vision for the near future is to turn the scientific output of the ERC Consolidator SPIN-PORICS into a new type of storage memory. MAGIC-SWITCH will deliver the prototype and business case for a new type of compact storage memory, at an industrial-relevant scale. The specific goal of this PoC project is to take the initial steps towards this vision by building a prototype (moving from Technology Readiness Level TRL 3 to 5), standardizing its manufacturing process and creating a business case for its commercial exploitation (including a pitch that can be used to close new partnerships or in fund-raising).

Keywords: data security,secure data storage device,magneto ionics,ferromagnetic antiferromagnetic coupling,magnetoelectric phenomena
MULTISCALE ANALYSIS OF FATIGUE IN Mg ALLOYS (MAFMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-09-15
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

According to the Europe police (EV5V-CT94-0375) Magnesium alloys are potential metals to be progressively introduced in structural components in many areas, especially in transport to reduce weight and achieve required CO2 reductions. As the deformation and failure mechanisms of Mg alloys are very complicated owing to basal slip, prism slip, primed slip and twinning, there lack reliable continuum level constitutive models for engineering application. This project will solve one of the most challenging open questions of Mg alloys, i.e. the influence of twin formation and persistent slip bands on the fatigue crack nucleation and growth by using rigorously scale-bridged models and in-situ experiments. Molecular dynamics, dislocation dynamics, phase field, nonlocal crystal plasticity finite element as well as cohesive zone method will be used to study twin nucleation, twin growth, persistent slip band as well as fatigue crack, respectively. The outcome of this interdisciplinary research proposal will be published in high impact peer-reviewed journals and at international conferences. The approach and the code developed in this proposal will improve the predictive power of Integrated Computational Materials Engineering concerning Mg alloy industry. The applicant will transfer his expertise and his international connection in the field of multiscale modelling to the host institute. He will work with researchers of the host institution to prompt new areas of research that can attract new funding. At the same time, he will receive regular training on transferable skills. All these activities will enlarge the portfolio of skills of the applicant and will ensure further development of his career.

Keywords: mg alloys,hcp crystal structure,slip,twinning,persistent slip band,fatigue crack,molecular dynamics,dislocation dynamics,crystal plasticity,cohesive zone,phase field
Structurally informed Design of Masonry Assemblages Composed of Interlocking Blocks (SiDMACIB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Masonry benefits contemporary architecture regarding sustainability and application to free-form construction. A masonry structure can be considered as an assemblage of conventional or interlocking rigid blocks with frictional joints. Although interlocking blocks’ resistance to sliding is higher and their construction is easier when compared to conventional blocks, there is no digital framework to design structurally-sound assemblages composed of interlocking blocks with diverse typologies. Therefore, I intend to develop a digital framework that supports designers in the design of structurally feasible and assemblable masonry assemblages of interlocking blocks. The framework will accomplish the following: -it allows designers to model an assemblage and to analyze its structural feasibility; -for the structurally infeasible model, it will automatically modify the geometry of the interlocking blocks’ connectors, making the model structurally feasible; -during the geometric modification, it will avoid geometries which do not construct the assemblable blocks. To evaluate the structural feasibility, a novel experimental method will equate the frictional resistance of the corrugated face of an interlocking block to that of the flat face of an equivalent conventional block. I also propose an extension of the limit analysis method, in which block resistance to sliding is different in different directions, and plan to use equations from the experimental method. The project is an interdisciplinary research in the fields of architectural, computational and structural design and will train skills helping to establish me as a researcher leading studies on structurally informed architectural design as well as to become an entrepreneurial architect who uses masonry in contemporary architecture. It will also create opportunities for host organizations to collaborate with architectural academia and manufacturing industry in the field of integrated architectural-structural design.

Keywords: interlocking masonry blocks,orthotropic friction,limit analysis of masonry block structures
EGFR signalling talks to mitochondria through contact sites (EGFRtoMITO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 1840125.0
EU funding (EUR): 920062.5
Participants: 2
Project status: SIGNED

The integration of distinct internalization routes is crucial to determine the fate of plasma membrane (PM) receptors and the output of their signalling pathways. Contact sites between cellular organelles adds a further layer of regulation by creating microdomains that favour different signalling and metabolic pathways. These regulatory mechanisms are relevant to the epidermal growth factor receptor (EGFR). We found that EGFR internalization through non-clathrin endocytosis (NCE) leads primarily to receptor degradation and signal extinction, while clathrin-mediated endocytosis (CME) is mainly involved in EGFR recycling and sustaining signalling. Notably, internalization via NCE involves the formation of contact sites between the PM, the endoplasmic reticulum (ER) and the mitochondria, where EGF-dependent localized Ca2+ signalling occurs. The founding hypothesis of this proposal is that the PM-ER-mitochondrial interface could represent a functional unit where direct cross-communication between EGFR signalling and mitochondria takes place. To investigate this hypothesis, we will use a three-tiered strategy aimed at elucidating: 1. the EGFR-dependent signalling that leads to NCE-ER-mitochondrial contact site formation and to local Ca2+ release, and the role of these contacts in EGFR endocytosis, signalling and fate; 2. the crosstalk between EGFR signalling and mitochondrial function at the PM-ER-mitochondrial interface by analysing the impact of EGFR-NCE on mitochondrial physiology and metabolism; 3. the relevance of NCE-ER-mitochondrial crosstalk to EGF-dependent cell physiological responses, e.g., migration, proliferation and differentiation, by exploiting isogenic cell derivatives from embryonic/pluripotent stem cells or ex vivo organoid cultures. The verification of this hypothesis will expand our understanding of the impact of EGFR signalling on cellular functions not previously linked to this pathway and possibly impinging on cellular energetics and metabolism.

Keywords: egfr signalling,endocytosis,er contact sites,mitochondria,calcium signalling,migration,metabolism
INDIVIDUAL ACTION THROUGH SOCIAL ORGANIZATIONS: THE CASE OF POVERTY (IATSO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-11-01
End date: 2021-07-31
Duration (months): 57.0
Total project cost (EUR): 1217313.76
EU funding (EUR): 1013571.57
Participants: 4
Project status: CLOSED

There is arguably a lack of research on organizations with social goals in management. For an extreme case, i.e., of poverty, Prahalad (2006) described compelling examples of innovative organizations in South Asia, which he suggested served the poor. However, very little is known about: 1) What factors ‘cause’ social organizations, for instance, in settings of extreme poverty, to grow and scale up ‘successfully,’ and how and why?, and 2) What organizational factors influence ‘social performance’ for target groups, and how and why, and under which conditions (where and when), and for whom? Building on insights from our earlier theoretical and empirical work on networks, leadership, and learning, as well as our extensive pilot studies in India, we will explore how and why social organizations grow and scale up, in relation to social outcomes for relevant target groups, using mixed methods (a qualitative phase followed by a quantitative phase, to first build and then test theory). We propose to study organizations in an extreme setting, where arguably, social problems are worst: of poverty in South Asia, and picked the education sector given its potential importance for enabling people to move out of poverty. We believe that a better understanding of how and why organizations scale up successfully to enable target groups in poverty to be more proactive is also relevant from a practical perspective. It is for instance at the heart of the new Sustainable Development Goals, and it is our hope to make a contribution into this direction.

Keywords: social organizations,poverty,education
New approaches in subaqueous PALEOseismology using high‐resolution SEISmics to derive single net paleoearthQUAKEs displacement and to characterize the seismic cycle on active faults (PALEOSEISQUAKE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-08-01
End date: 2019-07-31
Duration (months): 36.0
Total project cost (EUR): 239191.2
EU funding (EUR): 239191.2
Participants: 2
Project status: CLOSED

The study of past earthquakes is essential in modern seismic hazard assessment. Paleoseismology is a field of research that allows to characterize past earthquakes and to determine the seismic potential of the source faults based on the interpretation of the geological record. Thus, its strength is that covers much longer periods than the instrumental or historical seismic catalogues. Subaqueous paleoseismology merge and integrate paleoseismology and marine geology to detect and describe the occurrence of paleoearthquakes on faults located underwater. Recent advances in subaqueous paleoseismology have allowed to derive the submarine paleoearthquake records directly on-faults and their individual vertical displacement. The next step now is to move towards the obtaining of net displacements per event (normal and strike-slip components) and short term net slip-rates. The main objective of the PALEOSEISQUAKE project is to implement a new approach to characterize the seismic potential of active faults, with special emphasis on recognizing single net event displacements and obtaining precise net slip-rates. To achieve this objective different active fault systems located in the California margin (US) and Alboran Sea (southeastern Iberia) will be analyzed using closely-spaced grids (pseudo 3D) or 3D PCable surveys of high-resolution (HR) seismic data to derive 3D geological models where net displacements will be calculated. The resulting methodology will give more accuracy on the Quaternary slip rates of the faults and improve scientific knowledge about their behavior, but, also, reduce the uncertainties on the data used by scientists and civil protection authorities involved in seismic hazard assessment. PALEOSEISQUAKE is an original and innovative project that aims to develop a new scientific approach using modern analysis techniques, and will represent a step forward in subaqueous paleoseismology.

Keywords: active tectonics,active fault,paleoseismology,seismic cycle,net slip rate,net displacement per event,earthquake geology,tectonic geomorphology,marine geology,seismic hazard
COmposite repair solutions for aeronautical BUSiness development – Phase 2 (COLOMBUS-2)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: France
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-08-01
End date: 2018-07-31
Duration (months): 24.0
Total project cost (EUR): 1850000.0
EU funding (EUR): 1295000.0
Participants: 1
Project status: CLOSED

Composites are extensively used in many industrial applications, primarily in Transport. A technological sector dealing with composite repair solutions has emerged, now expanding proportionally to the extension of composites applications. GMI is a leading SME in this sector since 25 years, developing equipment for composite manufacturing, maintenance and repair. To ensure excellence, during the last 15 years GMI has invested in several EU co-funded R&D Projects, focusing on the development of innovative composite repair solutions. Today GMI possesses in its portfolio innovations deriving from >15 R&D projects focusing in composite repair: Advanced heating solutions for curing of complicated a/c composite repairs, Repair application equipment, for high performance adhesive bonding and Smart patches enabling SHM of critical a/c components. As there is a rising demand for this type of tools, both from the aeronautical and from other related industries (aolien, petroleum platforms, civil engineering), GMI objective is to improve its commercial position to those markets exploiting its technological excellence. Apart from direct equipment sales, a variety of related services will be additionally developed (training, studies for demanding repairs, consulting, certification support, logistics, application of advanced repairs, participation to R&D projects, etc). To this end 2 phases were specified: Phase 1- Development of a feasibility study, to examine technological, practical and economic viability issues, resulting in a realistic business plan for growth through “COmposite repair solutions for aeronautical BUSiness development COLOMBUS-1”; This phase has already been completed, following a grant won by EU. Phase 2: COLOMBUS-2 is now submitted, including required innovation and support activities for the materialization of prepared GMI plan. A sustainable yearly increase of turnover by 20% is expected for the next years, following implementation of COLOMBUS projects.

Keywords: aircraft structural repair,composite materials,bonded composite repair,adhesive bonding,out of autoclave curing,composite repair application