Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
One Network for Europe (OneNet)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Germany,Spain,Italy,Spain,Estonia,Italy,Ireland,Germany,Cyprus,Belgium,Greece,Hungary,Slovenia,Norway,Serbia,Finland,Finland,Finland,Finland,Greece,Hungary,Hungary,Lithuania,Poland,Poland,Poland,Slovenia,Slovenia,Slovenia,Sweden,Belgium,Latvia,France,Czechia,Czechia,Czechia,Czechia,Portugal,Luxembourg,Portugal,Portugal,United Kingdom
Call: TSO – DSO – Consumer: Large-scale demonstrations of innovative grid services through demand response, storage and small-scale (RES) generation (H2020-LC-SC3-2020-EC-ES-SCC, 2020)
Start date: 2020-10-01
End date: 2023-09-30
Duration (months): 36.0
Total project cost (EUR): 27900043.75
EU funding (EUR): 21998171.13
Participants: 79
Project status: SIGNED

While the electrical grid is moving from being a fully centralized to a highly decentralized system, grid operators have to change their operative business to accommodate for faster reactions and adaptive exploitation of flexibility. The topic has been subject of several research projects in the past years and reached a maturity that allows now the consideration of a final level, proposing an integrated view on the grid operations beyond the traditional barriers. OneNet aims at performing this critical step creating the conditions for a new generation of grid services able to fully exploit demand response, storage and distributed generation while creating fair, transparent and open conditions for the consumer. As result, while creating one network of Europe, the project aims to build a customer centric approach to grid operation. This ambitious view is achieved by proposing new markets, products and services and by creating a unique IT architecture. While a single platform for Europe is not thinkable, OneNet proposes innovative mechanisms of platform federation which are the key technical enablers for the proposed vision. The project has also very ambitious exploitation goals aiming at creating consensus on the solution far beyond the limits of the consortium partners thanks to a variety of actions including a large-scale forum for discussion within the international energy community. The complete concept is also proven in 4 cluster demos creating an involvement of an unprecedented number of countries and their grid operators in a single project. The consortium, in addition to a significant list of grid operators, includes also key IT players, leading research institutions and the two most relevant associations for grid operators, jointly providing a unique set of expertise in support to these challenging tasks.

Keywords: transmission systems,distribution systems,consumers,energy markets
ENhancing and prObing Strong light-matter Interactions in 2D materials by ultrafaSt optical techniques (ENOSIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

Strong coupling (SC) between light and matter in microcavities has shown to produce striking phenomena such as lasing at low power thresholds, Bose-Einstein condensation (BEC) and superfluidity in the solid state. Embedding transitional metal dichalcogenides (TMDs) monolayers and their heterostructures (HSs) with valley pseudo-spin degree of freedom in microcavities could bring enormous advantages. ENOSIS will enable and enhance the most favourable properties of SC in TMD-based devices, by investigating novel structures with advanced optical techniques relying on ultrafast spectroscopy and hyperspectral microscopy. To this aim, microcavities embedding TMD monolayers and HSs will be fabricated and characterized by developing new microscopy tools, which can provide fast and comprehensive information about the morphological and spectral properties of the samples. Ultrafast spectroscopic techniques will then reveal the subtle mechanisms behind the valley polarization enhancement in TMDs in the SC regime, towards a further increase of valley coherence time. Strong non-linear phenomena could then be observed in these structures for the first time, eventually resulting in BEC at high temperatures. ENOSIS will equip the Researcher with new knowledge and skills in ultrafast optical science and technology, thus broadening his scientific background and enhancing his prospects as an independent researcher. At the same time, the Action and the Host Institution will benefit from the advanced knowledge in 2D materials and strong light-matter interactions acquired by the Researcher during his scientific career. ENOSIS promises to open new horizons for 2D materials in optoelectronics, by enhancing their properties through strong light-matter interactions, creating novel highly non-linear optical devices which could become the building blocks for future optical circuits and computers.

Keywords: two dimensional materials,transition metal dichalcogenides,van der waals heterostructures,microcavities,strong coupling,polaritons,ultrafast optical spectroscopy,valleytronics
Ionic Liquid Interface Dynamcis (ILID)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-01-31
Duration (months): 64.0
Total project cost (EUR): 2498125.0
EU funding (EUR): 2498125.0
Participants: 1
Project status: CLOSED

The aim of the project is to take the ground-breaking step from our present knowledge of static properties to the understanding and control of dynamical processes at ionic liquid interfaces. Ionic liquids (ILs) are chosen as model systems for liquids in general for two reasons: First, their structural diversity allows their properties to be tailored over a wide range, and second, they can be studied using the extremely powerful methods of surface science in ultra-high vacuum due to their low vapor pressure. Such studies cannot be performed for conventional liquids, since they evaporate. ILs are not only relevant from a fundamental point of view, but also for a variety of applications. In catalysis, two new concepts have been put forward: Supported Ionic Liquid Phase (SILP) and Solid Catalyst with Ionic Liquid Layer (SCILL). In both, a high surface area solid substrate is covered with a thin IL film, which contains a dissolved metal complex for SILP, or which modifies active sites at the support for SCILL. For these and other applications, a fundamental understanding of the dynamical processes at the gas/IL and/or IL/support interfaces is strongly needed, but does not exist. Equally important, but even more challenging, is the investigation of the dynamics of chemical reactions in ILs, also under electrochemical conditions. Therefore, the applicant proposes a multi-method approach with new and unique setups to follow these dynamical processes in real time, that is, while they occur. Towards this goal, four key topics will be addressed: (A) How do gases pass through the gas/liquid interface? (B) How does the liquid/solid interface form? (C) Real-time studies of reactions in ILs, and (D) Real-time studies of electrochemical processes in ILs. The achieved insight will then enable to control the processes at the molecular level by tailoring the properties of the ILs. This promises a breakthrough not only for ILs, but for liquid interfaces in general.

Keywords: interface science,characterisation methods of materials,x ray photoelectron spectroscopy,scanning tunneling microscopy,molecular beam methods,method development
Developing novel tools and technologies to assess the safety and efficacy of cell-based regenerative medicine therapies, focusing on kidney disease (RenalToolBox)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Ireland,Italy,Germany,Germany,Italy,Belgium,Malaysia,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2018-11-01
End date: 2023-04-30
Duration (months): 54.0
Total project cost (EUR): 4071175.56
EU funding (EUR): 4071175.56
Participants: 15
Project status: SIGNED

The RenalToolBox ITN comprises a team of world-leading clinicians, scientists and industrialists from academia and private enterprise whose common goal is to develop innovative medical devices and imaging technologies to expedite the translation of cell-based regenerative medicine therapies (RMTs) to the clinic. The target disease for RenalToolBox is kidney disease, the incidence of which is increasing annually. The ITN provides an excellent framework for training 15 early stage researchers (ESRs) in a range of technological, entrepreneurial and transferable skills that will not only enhance their career prospects, but will also boost European scientific excellence and business innovation. By the end of the programme, the ESRs will have benefitted from a comprehensive multidisciplinary and multi-sectoral training experience that will equip them to expedite progress in the emerging supradisciplinary fields of biomedical devices, bio-imaging, cellular therapeutics and regenerative medicine. The research training objectives are as follows: 1. Train the young researchers in the development of diagnostic devices and novel tracers for monitoring renal function. 2. Apply cutting-edge imaging technologies to evaluate the safety and efficacy of novel cell-based RMTs in a rodent model of kidney disease. 3. Assess the safety and efficacy of different sources of mesenchymal stromal cells and explore the mechanisms whereby these cells can ameliorate kidney disease. This comprehensive training programme will endow the young researchers with the necessary scientific and industrial skills to ensure their employability and readiness to engage and lead the next European generation of scientists-entrepreneurs.

Keywords: kidney disease,mesenchymal stem cells,multimodal imaging,mathematical tools for image analysis,near infrared dyes,cell tracking nanoparticles,preclinical models,safety and efficacy
Surface functionalized-MoS2 nanofluids as high temperature lubricant additives (SmartLube)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-12
End date: 2022-12-09
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

There is an increasing and urgent need in Europe and globally for effective and robust high temperature (HT) lubricant additives in critical industrial applications. Combining synergistically the exceptional oil solubility of organic polymers and the excellent tribological behaviour of MoS2 nanoparticles (NPs), polymer functionalized-MoS2 NPs with good dispersion stability will be designed and synthesized as candidates for HT lubricant additives. In addition, to suppress MoS2 oxidation under HT, which would cause high friction and wear, carbon nanomaterials (CNMs) will be covalently combined with MoS2 NPs to improve the retention of MoS2 on the frictional surfaces and prevent oxidation during rubbing. In this project, MoS2 NPs will be functionalized by two methods: 1) Immobilization of organic polymer on the surface of MoS2 NPs using non-covalent and covalent approaches. The organic polymers including oil-soluble poly-(lauryl methacrylate) (PLMA), polyalkylene glycol (PEG), and hyperbranched poly(3-ethyl-3-hydroxymethyloxetane) PEHO; 2) MoS2 NPs growing on the surface of organic polymer modified-CNMs with covalent bonds. The polymers connecting CNMs and MoS2 NPs are novel PEHO and PEG derivatives with lipoic acid (LA) and nitrilotriacetic acid (NTA) terminals. The properties of the grafted polymers on MoS2 NPs and CNMs will be analyzed. The dispersion stability of surface functionalization MoS2 NPs will be assessed by SAXS/SANS, as well as cryo-TEM, SEM, DLS, and ξ- potential measurements. The surface force apparatus (SFA) will be used for mechanistic understanding of how such NPs mediate friction, with the macroscopic HT tribological properties of the NP dispersions investigated using tribometer. The correlation between the NP physicochemical properties and their efficacy in lubrication will be assessed. The wear mechanism of surface functionalized-MoS2 NPs as friction reduction and antiwear (AW) additives in lubricating oils will be explored by XPS and SEM-EDS.

Keywords: nanofluids,high temperature lubricant oil additive,friction reducing and antiwear,surface forces
Full-scale demonstration of a flexible inline production concept for breweries, drawing on water hydraulics (HYDRACTFLEX)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Austria,Germany,Denmark,Denmark
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2018)
Start date: 2019-08-01
End date: 2021-11-30
Duration (months): 28.0
Total project cost (EUR): 2635555.0
EU funding (EUR): 1844888.51
Participants: 5
Project status: CLOSED

The brewing industry is a strong pillar of the European economy with more than 2.3 million jobs linked with this industry. Today it is facing unprecedented challenges as the competition increases and the consumers are more demanding than ever. To remain competitive, breweries need to invest in solutions that may increase their productivity, cut costs and adapt quickly to what the market desire. HYDRACTFLEX vision is to introduce a new production paradigm concept – Flex Supply – that will enable for the first time integrated: High Gravity brewing, Just-In-Time production and inline mixing of beers, directly from the bright beer tanks, increasing productivity and decreasing costs for the end-user. HYDRACTFLEX will leverage a technological synergy between complementary innovations of technology providers (water-based actuators/valves (KMR), control software (ProLeiT) and monitoring sensors (ACM)) to offer a full package capable of regulate/control the new process with unprecedented precision, which is indispensable to unlock the full potential of Flex Supply. The overall aim is to mature and prove full functionality and benefits of the integration of the three core technologies that together will enable the Flex Supply concept, in the context of a full-scale demonstration, at Carlsberg (Fredericia, DK). The full-scale demonstration will overcome the remaining market barriers, while prove: reductions in costs, materials usage, energy demand, CO2 footprint, product losses; increases in flexibility and productivity; and enhanced beverage safety. HYDRACTFLEX will have a significant impact on the partners competitiveness and visibility. The partnering with a leading player is already a tremendous validation of the potential of our solutions and will be the definitive leverage for the market uptake, primary in the brewing industry, and later in other sanitary industries where precise regulation is fundamental, e.g. dairies, soft drinks, etc.

Keywords: high gravity beer,just in time production,beer production paradigm shift,water based actuator,accurate and fast control system,laser refractometry,inline blending,mixing of beers,energy savings
Quantitative modeling of cargo-carrier biogenesis for model-based design of drug-delivery systems (QARGO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Lipid-based drug delivery systems have shown great therapeutic potential, in particular for tumor targeting treatment. However, the production at relevant scales of such therapeutic agents remains a challenge due to the empirical nature of their development, and limited quantitative understanding of their biophysical properties. Remarkably, cells heavily utilize lipid carrier trafficking to encapsulate and transport with great efficiency various biological components to targeted sites in the intra- and extracellular environment. Inspired by the robustness of cellular trafficking processes, this proposal aims to elucidate the biophysical principles underlying the biogenesis of functional lipid carriers, and thereby direct the design and production of biomimetic transport carriers for drug delivery. Bringing together a complementary team of cell biologists, biophysicists, and mechanical engineers, we will develop a unifying modeling framework of vesicle biogenesis, in constant dialogue with experimental investigations of the mechanisms at play. The objectives of our integrated approach are two-fold: (i) elucidate the quantitative biophysical mechanisms of transport-carrier biogenesis mediated by coat proteins; and (ii) provide a toolbox for model-based design of liposome technologies for therapeutic drug delivery. All together, this project has potential impact in fundamental biology - by providing a systematic framework to formulate experimentally testable predictions and develop new ideas to control cellular functions in health and disease – as well as in biomedical engineering – by offering in silico solutions to design and test biomimetic cargo-carrier production processes for therapeutic applications.

Keywords: cargo transporter,copi,copii,endoplasmic reticulum,golgi,lipid membranes
Microfluidic chambers for establishing physiological and pathological human iPSC-derived neuronal circuits (BrainCircuit-on-chip)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-08-01
End date: 2021-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

In vitro cultures of brain cells generate an ease and accessible ensemble of neurons In vitro cultures of brain cells generate an ease and accessible ensemble of neurons which has been invaluable for innumerable cellular and molecular studies. However, brain tissue dissociation and neuronal plating in vitro causes a complete loss of the original connections present into the brain tissue. Therefore, in vitro neuronal cultures do not allow to model specific neuronal circuits and study their specific properties. The same limitation is valid for human stem cell-derived neuronal cell cultures. In fact, several neuronal cell types can be differentiated from human iPS cells (iPSCs), but without any organization in terms of connectivity or synaptic specificity. We have established a microfluidic platform, named BrainCircuit-on-chip, which allows to growth human iPSC-derived neurons with a stereotyped organization and to establish patterned connections between different neuronal cell types. These microchips contain a central chamber where synapses between the two neuronal cell types are generated establishing the correct functional integration between the two neuronal populations. PDMS-microfluidic chambers are transparent and enables high-power and time-lapse imaging in the different neuronal compartments for sub-cellular and molecular studies. Moreover, the design of the central chamber enables to expose the synapses to chemicals or other cells types like astrocytes or microglia to study their effects on a specific class of synapses. We will produce a convenient kit with the frozen human neurons, the microfluidic chamber and a detailed protocol for generating the patterned neuronal circuits for research studies, compound testing and toxicology research.

Keywords: microfluidics,organ on chip,stem cells,parkinson s disease,neuronal circuits
Blocking Inhibition of T-cell Co-stimulation for Anti-tumour Therapy (BITCAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Canada
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-05-08
End date: 2020-05-07
Duration (months): 36.0
Total project cost (EUR): 243352.8
EU funding (EUR): 243352.8
Participants: 2
Project status: CLOSED

Tumours escape proper immune response by propagating immune suppression. Immunotherapy aims to enhance anti-tumour immunity. This highly relevant research area arose recently from advantages in immunology, genetics and oncology. Currently, immunotherapeutics are either protein (e.g. antibodies) or cell-based (e.g. cancer vaccines) and promising approaches target immune checkpoint control, a mechanism crucial for anti-tumour T cell activity. Here, development of a completely new class of immunotherapeutics based on advantageous oligonucleotides is proposed. To this aim, oligonucleotides will be designed to modulate expression of receptor genes involved in immune checkpoint control (e.g. PD-L1, CTLA4) and thus block tumour-mediated T cell inhibition. Of special interest will be the employment of the exon skipping technique to reduce surface receptor and potentially induce antagonistic soluble isoforms. To ensure delivery of oligonucleotides, liposomal or polycationic nanoparticles will be utilized as previous studies demonstrated good tissue bioavailability, e.g. for PTO-antisense RNA and polyethylenimine. Oligonucleotides will be tested for functionality, efficacy and non-toxicity in vitro. To facilitate practical clinical application of the developed drugs, most promising candidates will then be applied to pre-clinical tumour models in vivo. Charmingly, this novel technique will also be applied ex vivo to enhance anti-cancer cell therapy, thus evading systemic distribution. Collaboration of two world-renowned scientific institutions, the German Fraunhofer society and Canadian partner McMaster University, will ensure a prolific environment for successful project conclusion and allow considerable advancement of the career of a most promising European researcher. Furthermore, the project will support development of a key technology in the important field of cancer therapy, thus providing a significant competitive advantage for European interests in health research.

Keywords: cancer immunotherapy,oligonucleotide based therapeutics,immune checkpoint control