Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A materials informatics approach to the Pauling’s rules and structure-property relationships in low thermal conductivity materials (JG-GH-UCLouvain)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

Inorganic crystalline materials promise solutions to some of our major global problems. Thermoelectric materials, for example, are expected to increase the energy efficiency of many electric devices or production sites to lower the global need for energy. To arrive at materials with properties relevant for thermoelectric applications, a better understanding of structure-property relationships could play a key role. Linus Pauling’s famous five rules on the stability of crystal structures will serve as a starting point for such an improved understanding because they describe the relation between structure and stability based on coordination polyhedra and their connections. They will be assessed for oxides and other chemistries. This will be based on the Materials Project database and a recent study of the statistics of coordination environments in oxides from the host institute. Next, a graph representation of crystal structures based on coordination polyhedra and their connections will be established to go beyond Pauling’s rules. The graphs will then be analysed and classified. Beyond stability, there is a recent design principle relating coordination polyhedra to lattice thermal conductivity–an essential property for thermoelectrics. It will be applied to search for oxides as potential candidates for thermoelectric applications. The design principle is based on the instability of small cations in octahedral coordination environments that is connected to low thermal conductivity. The recent development of one of the first databases of phonon computations at the host institute offers a great opportunity to link phonon and especially soft modes to coordination environments. The best candidates from the search will be synthesized and analysed by a cooperation partner of the host institute. In sum, the project is expected to lead to a better understanding of coordination polyhedra, their connections, and their relation to the stability and other properties of crystals.

Keywords: coordination environments,structure property relationships,ab initio calculations,density functional theory,materials discovery,high throughput computing
Bio Ring Diagnostics (Bio Ring Diagnostics)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Tuberculosis (TB) is one of the largest world health problems: annually 10 million people become ill and 1.5 million people die from TB. According to World Health Organisation (WHO) this is largely attributed to the fact that 4 million TB patients are not diagnosed each year, due to lack of a good diagnostic tests. According to European Centre for Disease Prevention and Control (ECDC) in 2017 323.000 new cases of TB have been registered and 32.000 Europeans died from TB. On global scale all pharmaceutical companies, clinical research organisations and life science research institutes depend on surface plasmon resonance (SPR) instruments for swift (bio-molecular interaction) detection of diseases and for specific research. SPR is an inherently expensive technique and therefore limited available. There is globally a large unmet need for a cost-effective instrument with similar functionality and sensitivity as SPR and multiplexing capabilities for measuring such real‐time biomolecular interactions. Delta Diagnostics has developed an instrument capable of swift bio-molecular interaction detection. This instrument employs Photonic Integrated Circuits (PICs), more specifically so-called ring resonators. Within this project Delta Diagnostics sets out to study the feasibility of the development of a minimal viable product (MVP) of this low cost instrument. This instrument can rival conventional SPR sensors, yet at a fraction (close to a tenth) of the costs. The MVP will make label-free biomolecular interaction analysis technology globally available in a small and cost-effective device. The platform technology behind it, will further contribute to the development of even smaller and more versatile and more accurate point of care (portable) diagnostics. The product will disrupt the world of clinical, chemical and biological laboratories and scientific institutions and will contribute greatly to making portable diagnostics globally available.

Keywords: bio molecular interaction analysis,photonic integrated curcuits,point of care diagnostics
Probing CD28 as checkpoint for T cell co-stimulation in cancer and infection (CD28)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-29
End date: 2024-10-28
Duration (months): 36.0
Total project cost (EUR): 245732.16
EU funding (EUR): 245732.16
Participants: 2
Project status: SIGNED

Regulation of T cells has been a cornerstone in the development of therapeutics for fighting a wide plethora of pathologies, including cancer, chronic infections and disease. The mechanisms governing activation or repression of T cells depend on several receptors which provide “second signals” following the initial interaction with APCs presenting MHC complexes. Among these receptors, CD28 constitutes the main interest for this project. Its role as co-stimulator of T cell activity is known for so long. However, the particular mechanisms underlying its effective interaction with its cognate ligands (CD80/CD86) remain unclear yet. In particular, the present project is aimed at exploring the possible role of sialic acid in regulation of CD28 co-stimulatory activity (via inhibition), which could provide a novel explanation for the so-called “neuraminidase effect” described for decades. This effect leads to enhanced antigen-mediated T cell activation when sialic acids are enzymatically removed, but its origin is uncertain. Additionally, the structural basis for CD28 regulation will be explored, putting an special emphasis on its exploitation for the design of molecular platforms which may serve for reactivation of exhausted T cells in tumor models. The proposed project will be jointly undertaken by two renowned groups with large and solid experience in the field of glycomics, at CIC bioGUNE (J. Jiménez-Barbero) and Scripps (J.C. Paulson). The applicant, under their guidance, will develop the project from a very wide and cross-disciplinar perspective, covering all unknown aspects related to CD28 so far as well as proposing a novel methodology to translate this knowledge into valuable goods for society. The success of the project will likewise have a remarkable impact in the field of immunotherapy-based treatments for patients with cancer or chronic infections.

Keywords: cd28,sialic acid,t cell co stimulation,t cell activation,sialidase,molecular recognition,chemoenzymatic synthesis,immunotherapy,chronic infection,cancer
INdependent LIving support Functions for the Elderly (IN LIFE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Innovation actions
Countries involved: Austria,Austria,Ireland,Spain,Spain,Spain,Spain,Sweden,Slovenia,Greece,Sweden,Greece,Netherlands,United Kingdom
Call: Advancing active and healthy ageing with ICT: ICT solutions for independent living with cognitive impairment (H2020-PHC-2014-single-stage, 2014)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 3761728.75
EU funding (EUR): 3383841.25
Participants: 21
Project status: CLOSED

The number of elderly living with cognitive impairment is growing rapidly due to increasing life expectancy. The percentage of those who live alone depends upon the condition (i.e. roughly 30% of those diagnosed with dementia) but the majority would like to live in their own home or with family, provided that it is safe, comfortable, and cost effective. IN LIFE aims to prolong and support independent living for elderly with cognitive impairments, through interoperable, open, personalised and seamless ICT services that support home activities, communication, health maintenance, travel, mobility and socialization, with novel, scalable and viable business models, based on feedback from large-scale, multi-country pilots. Building on existing knowledge and tested AAL technology/services IN LIFE will offer 19 different services, which will be further optimised and adapted to the particular needs and wants of various elderly groups, including mild cognitive impairment (MCI), early dementia and cognitive impairment with co morbid conditions, plus formal and informal caregivers. These interoperable services will be integrated into an open, cloud- based, reference architecture to be tested in 6 Europe-wide pilots in Greece, Netherlands, Slovenia, Spain, Sweden, and UK, with over 1200 elderly with cognitive impairments, 600 formal and informal caregivers, and 60 other stakeholders. Attention will be paid to issues concerning multilingual and multicultural environments. The project will establish and extensively test new business models for a new taxonomy of elderly with cognitive impairments, encompassing those that are clustered as “dependent”, “at risk”, “assisted” or “active” and formulating and accessing new business scenarios, such as the “user-centric”, “service provider-centric” and “data exploitation-centric” ones. This work will be carried out in 36 months by 20 partners from 9 European countries, totaling 591PMs with a total requested financing of 3.38M€ euros.

Keywords: elderly with cognitive impairment,ict solutions,independent living,communications and social interaction support,reference architecture,user profiling,business models,personalization
Solving The Pathway of LADDERane biosynthesis (STePLADDER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2023-05-31
Duration (months): 72.0
Total project cost (EUR): 1753125.0
EU funding (EUR): 1753125.0
Participants: 1
Project status: SIGNED

Ladderanes are highly unusual hydrocarbon moieties with linearly concatenated cyclobutane rings. They are found in the membranes of bacteria performing anaerobic ammonium oxidation (“anammox”). How these complicated molecules are produced is expected to involve both novel enzymes and specially evolved versions of known proteins, but the details remain enigmatic. How do these enzymes assemble such intricate carbon skeletons? How do they control the complex stereochemistry involved? How do they deal with the typical nonreactivity of hydrocarbons? And how do they overcome the ring strain inherent in these molecules? Answering these and other questions about the molecular mechanism of ladderane biosynthesis will open up new frontiers in enzymology. I therefore propose to elucidate the pathway of ladderane biosynthesis. I will use a synergistic approach, combining biochemistry, chemical biology and structural biology to arrive at a comprehensive view of ladderane biosynthesis in molecular detail. Heterologous expression of selected biosynthetic gene clusters will be used to study ladderane biosynthesis in vivo. Chemical biology will be used to load ladderanes and their intermediates onto carrier proteins to study their interactions with enzymes from the biosynthetic pathway in vitro. Protein crystallography will elucidate structures of enzymes and their complexes with ladderane-loaded carrier proteins. The knowledge accumulated will not only break new ground in enzymology, but also serve as a stepping stone for the use of these enzymes in bioinspired organic synthesis.

Keywords: chemical biology
enabling Consumers to Learn about, Engage with, Adopt and regulate Renewable energy technologies 2.0 (CLEAR 2.0)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Italy,Spain,Belgium,Slovenia,Czechia,Portugal,United Kingdom
Call: Engaging private consumers towards sustainable energy (H2020-EE-2016-CSA, 2016)
Start date: 2017-09-01
End date: 2020-02-29
Duration (months): 30.0
Total project cost (EUR): 2397182.5
EU funding (EUR): 2397182.5
Participants: 8
Project status: CLOSED

CLEAR 2.0 - enabling Consumers to be Engage with and Adopt Renewable energy technologies. 2.0- is a new project that builds on the learning of an EU funded project IEE13-588 CLEAR. It will actively guide consumers in the energy market and enable them to be more aware, active players, save money and easily become "prosumers". The Consortium will accompany consumers through all the stages leading to the purchase and the correct efficient use of domestic renewable and low-carbon energy technologies. The CLEAR 2.0 project will focus as well on changing behaviour and optimisation of existing installations. The main needs of a home, including heating/cooling and electricity production (including storage and monitoring systems) will be addressed through a consumer-centric approach and actions that will lead to the changing behaviour and form collective consumer groups to support the purchase of renewable energy technologies such as photovoltaic installations, batteries, pellet stoves and heat pumps for heating and cooling. The three major barriers (awareness, behaviour and price) to the investment in RES will be directly addressed, having as a result a higher consumer engagement. BEUC and the consumers organisation focus their advocacy work on relevant legislative developments in order to overcome existing barriers and facilitate consumers’ participation in the energy market. It will distil policy lessons to create a favourable and stable national and European policy framework for the benefit of all European consumers.

Keywords: renewable energy,change behaviour,group purchases
Wave-modulated Arctic Air-sea eXchanges and Turbulence (WAAXT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Wave-modulated Arctic Air-sea eXchanges and Turbulence (WAAXT) is a project designed to improve our understanding of ocean boundary layer processes in a changing Arctic Ocean. Sea ice extent in the Arctic Ocean has been decreasing since the beginning of the satellite era, meaning that open-water, as opposed to under-ice, oceanographic processes are becoming increasingly important for Arctic dynamics. One of the most fundamental differences between the open and ice-covered oceans is the presence of surface waves. Surface waves and wave-driven processes drastically alter air-sea fluxes, upper-ocean turbulence, and the dominant dynamical balance in the upper ocean. WAAXT will be based on a series of field experiments to study the small-scale processes associated with this emerging wave climate, with a particular focus on near-surface turbulence. Three major effects of wave processes will be targeted: 1) Modification and suppression of ice formation by wave motions and the associated elevated near-surface turbulence. 2) Physical breakup of sea ice by wave motions, and the associated contributions to the modification of air-sea fluxes, upper-ocean structure, and melt rates. 3) Interactions between wave-driven turbulence, especially breaking and Langmuir circulations, with the unique salinity-based stratification in the Arctic basin. A key aspect of these processes is their horizontal variability, which will be captured using a multi-platform approach. Experimental work will begin in a natural laboratory in the Saint Lawrence Estuary and move to the Arctic as scientific and technical capacity is developed. The long-term goal for WAAXT is to produce the data and parameterizations needed to understand climate-scale feedbacks associated with the emerging wave climate in the Arctic basin.

Keywords: air sea interactions,sea ice,waves,upper ocean turbulence,breaking
The EU Migration/Refugee crisis and border security: a contribution to theory and practice through the case of Hungarian-Serb border policing practices (SECURE BORDERS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2023-09-01
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

In 2015 more than 1 million refugees and migrants entered Europe largely from conflict-ridden states such as Syria, Iraq and Afghanistan. The Hungarian government single-handedly decided to stop the migration by building a barbwire wall along the Hungarian-Serb border. Many observers agree that building the fence was primarily a domestic political act to help the Prime Minister Viktor Orbán and his party Fidesz to gain the far-right vote in support of his and his party’s re-election. Nonetheless, his landslide victory, predictably won on a populist ticket rallying against migrants and Muslims in April 2018, together with media and NGO reports on the treatment of migrants and refugees seemed to suggest to the outside world that the Hungarians were predominantly right-leaning, anti-migrant people who lack humanitarian compassion and are thus different from other Europeans. As my preliminary findings of exploratory research at the Hungarian-Serb border in summer 2018 suggest, however, the situation is much more nuanced. There is a substantial gap between the border police, local policing organisations, the local border communities, on the one hand, and local and national politicians, and the international media perception of the events and the Hungarian migration/refugee crisis and border security management, on the other. At the theoretical level, this raises a larger issue in security studies: how does securitizing work in practice? Taking securitization practices seriously through focusing on everyday performances of security, this project aims to analyse (1) how communities manage security concerns locally (especially when these concerns are ignored in the national or international spheres); (2) how local security concerns are mobilised elsewhere for political gains; and (3) how mistrust between communities is generated locally, nationally and internationally in order to explain the de-facto re-militarised EU border.

Keywords: ir theory,practice theory,hungarian serb border,border police,eu migration,refugee crisis,transit,countries,ethnography
Complementary Adhesive Coatings based on Molecular Association (CompAd)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-05-01
End date: 2018-04-30
Duration (months): 12.0
Total project cost (EUR): 149975.0
EU funding (EUR): 149975.0
Participants: 1
Project status: CLOSED

Adhesives constitute a potent and very broad technology, offering innovative solutions to a wide range of industries and providing craftsmen and private consumers with easy-to-use technically-advanced products. For every application in which two elements need to be fastened together, a specific adhesive can in principle be formulated. We aim at developing a novel adhesive technology, CompAd, that ultimately targets the commercialization of adhesive formulations for coating different surfaces, producing materials where bonding: 1) occurs under a pressure-sensitive contact mechanism; 2) can be classified as weak; 3) is reversible; and 4) takes place between two complementary surfaces. CompAd technology is based in chemically mimicking the operation of materials like Velcro® by using, in a bioinspired approach, complementary noncovalent interactions between molecules. This PoC Project therefore endeavours to bond the scientific bases, technical know-how and expertise acquired during the last years in the ERC Starting Grant PROGRAM-NANO project, with a novel potential applied technology that aspires to provide industry and society with an unconventional chemical adhesive product. The range of potential applications of the CompAd technology is broad, so we will focus in this project on identifying the most lucrative and feasible market niches as a function of the technical adhesion parameters measured in standard prototypes. This requires the assembly of a team comprising experienced researchers on one hand, to validate CompAd performance through well-established standard tests, and management, market and IPR experts on the other, to develop the most convenient business strategy for the exploitation of our technology. Due to its innovative nature and versatility, CompAd has a great potential to open up important technological and commercial opportunities in the design and applications of future smart adhesives.

Keywords: supramolecular chemistry,noncovalent molecular interactions,polymer chemistry,adhesives,coatings