Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Foundations for Sustainable Security (FSSec)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 1498489.0
EU funding (EUR): 1498489.0
Participants: 1
Project status: SIGNED

Security and efficiency are often seen as a conflict. IT already consumes 11% of electricity globally, with a steep upwards trend. Resource sharing increases efficiency but introduces information leakage vulnerabilities, such as Meltdown and Spectre. Reducing reliability margins also increases efficiency but introduces fault attacks, such as Rowhammer and Plundervolt. This reveals a fundamental problem in current systems: Reliability mechanisms are not designed with adversaries in mind. Security is then patched on top of reliability mechanisms, incurring additional energy costs. We will overcome the conflict between security and efficiency with novel foundations to make security sustainable and use security to increase efficiency. We will research how to measure the efficiency of security, design principled and efficient security mechanisms, utilize security to increase efficiency, secure microarchitectural optimizations, and secure lightweight isolation. Our methodology is to integrate principled cryptography-grade security into all system layers to minimize and supersede inefficient reliability mechanisms. We will develop a framework for fine-grained energy efficiency measurements. We will research fine-grained replication for side-channel isolation, maintaining efficiency. We will explore selective resource sharing for secure variables, enclaves, and virtual machines, superseding today's inefficient and insecure techniques. The originality of FSSec stands out in that energy efficiency has played no role in security so far. In particular, using cryptography to replace established error correction methods will be the key to our goal of using security to increase efficiency by 20% compared to current systems. We will construct secure optimizations with fine-grained isolation, increasing the efficiency without adding side channels. Asst.-Prof. Daniel Gruss heads an internationally renowned security research group. FSSec will fund 6 PhD students.

Keywords: side channels,system security,microarchitecture security,efficient security,sustainable security
Understanding and embracing artificial agents’ impact on the social dynamics of families (F-AI-MILY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 1499930.0
EU funding (EUR): 1499930.0
Participants: 1
Project status: SIGNED

How we trust, feel, understand, and connect with family members shapes the well-being of all family members. With families increasingly inviting artificial agents into their life, questions arise how we can describe these dynamics in the age of artificial intelligence. Integrating insights and methods from family psychology, social neuroscience, and human-ai interaction, F-AI-MILY will 1) establish a new group-centred mobile-lab approach to study the neurocognition of family social dynamics, 2) describe the developmental aspects of changes in households’ social dynamic during long-term interactions with artificial agents, and 3) identify how sustainable interactions with artificial agents can provide support in households with chronic illness. First, we will develop a new group-centred mobile lab to study how the key mechanisms of social dynamics, similarity and distance between family members, are impacted by interactions with artificial agents. Using this innovative neurocognition-at-home approach we will measure both behavioural and brain measures of key attitudes and behaviours of all family members and uncover social dynamics with unprecedented detail and clarity. Second, we will test how child development interacts with the impact of artificial agents on social dynamics. Going beyond one-off interactions, we will directly test how long-term living with an artificial agent affects families with children (4-12 years) that differ in their flexibility to the influence of these agent. Third, we will use the neurocognition-at-home approach to guide the development of artificial agents to support vulnerable households. This artificial agent support system targets family coping with chronic illness and aims to change maladaptive to adaptive social dynamics. The innovative, interdisciplinary, and full circle approach of F-AI-MILY offers new ground-breaking vistas on family systems, neurocognition of social behaviour, and the developmental of artificial agents.

Keywords: social dynamics family artificial intelligence,neurocognition artificial agents social robots digital voice assistants social interaction
CRISPR/Cas-based innovative electrochemical multiplexed immunosensor for specific detection of ovarian carcinoma biomarkers in urine (CRINOVA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Serbia
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 2
Project status: SIGNED

Ovarian carcinoma (OC) is a leading cause of cancer deaths in postmenopausal women worldwide. Unfortunately, it is diagnosed in the advanced stages (III/IV) with five-year survival rate of 20% and poor prognosis due to lack of distinct early symptoms. The current diagnostic tools (pelvic examination and imaging techniques) often fail to detect premalignant tumors and standard biomarker (cancer antigen 125) analysis show low sensitivity and specificity. The goal of this proposal is to develop a radically innovative modality in the field of early diagnosis of ovarian cancer. I propose cutting-edge CRISPR/Cas (Clustered regularly interspaced short palindromic repeats/CRISPR associated protein) technology-based molecular diagnosis as the next generation OC screening tool. The proposed CRINOVA project will apply the CRISPR-mediated biosensing approach for the first time combining with immunoassay to detect OC protein biomarkers (cancer antigen 125, human epididymis protein 4 and mesothelin) noninvasively in urine of early stage (I/II) OC patients through electrochemistry. The nucleic acid programmed nuclease activity of Cas effector protein will be activated upon sequence-based recognition of guiding RNA of CRISPR by a single strand DNA in the presence of biomarkers resulting in their highly specific and sensitive detection. The purpose of the project is linked to improving prognosis of OC patients, making a direct impact on enhancing their quality of life. This major objective will be achieved through a cross-disciplinary approach involving my wide experience in electrochemical biosensor development and the expertise of my supervisor on DNA nanotechnology and CRISPR-based biomolecular sensors. I have an excellent track record of scientific collaborations undertaking international mobility in different laboratories globally. The outcome of the fellowship will be crucial to boost my career in academia and to achieve a permanent position (i.e. professorship) in Europe.

Keywords: biosensor crispr cas,protein biomarkers,ovarian cancer,paper based spes,noninvasive detection
MicroScale system integrating Patient-specific cancer Organoids in a 3D Tumor microenvironment for Therapy rEsponse preDiction (SPOTTED)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-06-01
End date: 2026-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Cancer remains a leading global cause of death, with incidence projected to increase significantly by 2050. Despite advances in detection and treatment, there is an urgent need for more effective and personalized therapies. Personalized medicine (PM) is emerging as the future of cancer care, using 3D patient-specific models to replicate the tumors complexity. Current in vitro models struggle to accurately mimic the tumor microenvironment (TME), including the extracellular matrix (ECM) and stromal interactions, which are critical to tumor progression and therapy response. SPOTTED aims to address these limitations by developing patient-derived (PD) in vitro models integrated into a microfluidic device, by exploiting patient-derived organoids (PDOs) from bioptic tissues from the Biobanca di Ricerca of the University Hospital of Padua. The first vertical case study is on pancreatic cancer (PC), projected to become the second deadliest type of solid tumor by 2040. Our SPOTTED platform will use PDOs and PD-ECM hydrogels to reconstruct a realistic 3D model of PC, incorporating stromal and immune cells. By replicating the TME, SPOTTED enables precise drug screening and therapeutic testing in a highly controlled and automated environment. Its design allows for real-time monitoring and analysis, while the platform’s versatility supports scalable, reproducible experiments tailored to individual patients. SPOTTED, with its customizable, patient-specific approach, aims to bridge the gap between laboratory research and clinical application, paving the way for more effective, tailored therapies for PC and other solid tumors, with the potential to revolutionize personalized cancer treatment.
Alkaloids as signals of stress to modulate microbiome assembly in tomato (Solanum lycopersicum) (ALKBIOTA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Switzerland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 217965.12
EU funding (EUR): 217965.12
Participants: 2
Project status: SIGNED

Plants host diverse communities of microorganisms called plant microbiome that provide specific services by several mechanisms. Because of its capacity to enhance plant nutrient uptake, yield, and tolerance to challenging conditions, the rhizosphere microbiome stands as a valuable bioresource for fostering sustainable agriculture. However, there remains a lack in comprehending the process of interaction within the rhizosphere-microbiome ecosystem. Plants secrete a broad of secondary metabolites, which vary with species and may interact with the biota. Alkaloids, a class of secondary metabolites play a major role in plants' signaling and defense. Although significant progress has been made in elucidating the role of polyphenols in controlling Arabidopsis roots microbiome, little is known about the impact of the alkaloids on microbiome shaping. In this project, we intend to dissect the hidden role of alkaloids in controlling the root microbiome of tomato in response to biotic/abiotic stress and to determine the related microbial processes and services that will help the plant under stress using a multidisciplinary approach. We first seek to identify the effects of Phytophthora infestans attack and nitrogen deficiency on the composition of tomato root-microbiome. Then, we intend to unravel the biological role of alkaloids on microbiome control under stressful conditions. Afterward, the interrelation microbiome and alkaloids will be better defined using SynComs. Finally, we will employ bioinformatics pipelines to analyze data and to decode the correlation alkaloids-microbiome-plant performance. The outcomes of this project will provide new insights on the interaction tomato-alkaloids and microbiome, allowing for a better understanding of alkaloids, and how tomato use it to communicate with the microbiome under stresses. It will reveal promising avenues for leveraging alkaloids as signals to control and harness the rhizomicrobiome to enhance tomato fitness and production

Keywords: alkaloids,rhizomicrobiome,tomato,plant secondary metabolites,stress,bioinformatics
ALD-protected Next Generation Lithium-Sulfur battery Cell (ANGeLiC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Estonia,Slovakia,Poland,Germany,United Kingdom,Czechia,France,Israel,Belgium,Spain
Call: Post-Li-ion technologies and relevant manufacturing techniques for mobility applications (Generation 5) (Batt4EU Partnership) (HORIZON-CL5-2024-D2-02, 2024)
Start date: 2025-06-01
End date: 2028-11-30
Duration (months): 42.0
Total project cost (EUR): 4992189.13
EU funding (EUR): 4992189.13
Participants: 13
Project status: SIGNED

The proposed project aims to revolutionize battery technology by developing Generation 5 batteries based on lithium-sulfur (Li-S) chemistry to meet the growing demands of mobility applications focusing on heavy-duty vehicles. This project will address critical challenges in battery performance, safety, and sustainability by innovating in materials, cell design, and manufacturing processes. By employing advanced techniques such as Atomic Layer Deposition and Molecular Layer Deposition, we will enhance the protection of lithium-metal anodes, thus overcoming the issues of a dendrite Li growth and low coulombic efficiency, which have hindered the commercialization of Li-S batteries so far. The consortium will develop scalable and manufacturable surface coatings, integrating these advancements into Li-S batteries to achieve higher energy densities, extended cycle life, and improved safety profiles. The project will also focus on creating batteries with designs that facilitate end-of-life recyclability, aligning with the European Union's objectives for sustainable and circular battery technologies. To ensure the practical application and scalability of these technologies, the project will evaluate the compatibility of the new manufacturing processes with existing lithium-ion production infrastructure. This will include proof-of-concept demonstrations at the small pilot line scale, paving the way for future commercialization and widespread adoption of Gen5 battery technologies in the automotive sector and beyond. The outcomes of this project will contribute significantly to the European Union’s goals of achieving a sustainable, circular, and competitive battery ecosystem, thereby supporting the broader objectives of the European Green Deal and the transition towards a climate-neutral economy by 2050.

Keywords: lithium sulphur batteries green deal
Sustainable, safe, and high-performance bio-based adhesives for wood-based composites (SUSPENSE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Greece,Spain,Finland,Türkiye,Norway,Germany,France
Call: Innovative bio-based adhesives and binders for circular products meeting market requirements (HORIZON-JU-CBE-2024, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 9304007.5
EU funding (EUR): 7488697.0
Participants: 17
Project status: SIGNED

The SUSPENSE project aims to develop and demonstrate innovative safe and sustainable bio-based adhesives to replace conventional fossil-based adhesives, which are harmful to the environment and human health. The project focuses on creating adhesives from renewable feedstocks such as bio-acids, polyphenolics, proteins and other bio-derived materials. These adhesives will meet market demands and regulatory standards and will be used in wood-based panels (Plywood, Particle Board, and MDF), and wood-based insulation materials. The technical performance of the adhesives will be validated through comprehensive industrial testing. The project will introduce two production routes for bio-based adhesives: the Acids Route and the Polyphenolics Route. The Acids Route will use bio-acids and various bio-derived raw materials like hemicellulose sugars, proteins, and vegetable oils to develop adhesives with high water resistance and bonding strength. The Polyphenolics Route will leverage natural compounds like protein, chitosan, and functionalized lignin to produce adhesives with strong bonding capabilities and moisture resistance. To ensure the practical applicability and scalability of the developed solutions, the project will include several demonstration cases. These cases will provide real-world validation of the bio-based adhesives in different industrial applications, focusing on wood-based panels and insulation materials as well as producing furniture using the panels. The recyclability of the end applications will be validated based on the induced ability of the developed adhesives for debonding. The SUSPENSE project aims to significantly reduce CO2 emissions, improve sustainability and circularity, and foster increased consumer acceptance of bio-based adhesives. By achieving these objectives, the project will contribute to the European Union's goals for a Circular Economy and Zero Pollution.

Keywords: wood adhesives,bio based resins,wood based panels,circular economy,zero pollution,insulation panels
Deciphering the molecular mechanisms governing PARP14 ADP-ribosylation activity and its interplay with ubiquitylation signalling (UbADPrLINK)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: CLOSED

Intricate networks of post-translational modifications (PTMs) shape how cells respond to environmental threats. Adenosine diphosphate (ADP)-ribosylation (ADPr) has emerged as a pivotal PTM elicited by DNA damage or host immune responses to combat viruses, including SARS-CoV-2. This protective ADPr signature can be regulated by PARP14, a versatile enzyme that can both install and remove ADPr. While the connection between ADPr signalling and these damaging events is clear, the physiological targets and functions of PARP14-mediated ADPr remain ill-defined. Recently, a cryptic link between PARP14 ADPr and ubiquitylation signalling has arisen, adding complexity to PARP14-regulated processes. This ambitious research program ‘UbADPrLINK’ aims to dissect the mechanistic underpinnings of PARP14 ADPr and its link with ubiquitylation using an integrative approach, merging proteomics, structural, biochemical methods. UbADPrLINK will focus on four areas. First, we will precisely map and characterise cellular PARP14-catalysed ADPr sites on important targets by reconstituting ADPr in vitro. Concurrently, we will study the structure-function relationships of PARP14 and explore the roles of uncharacterised PARP14 domains and auto-modification in regulating its activity. Next, we will attempt to decipher the interplay between PARP14 and the PARP9-DTX3L complex that is known to regulate PARP14 activity using unclear mechanisms. We will structurally characterise the PARP14-PARP9-DTX3L complex and assess its potential to simultaneously modify targets with ADPr and ubiquitin. Finally, we will launch a drug discovery campaign to discover cyclic peptides capable of modulating SARS-CoV-2 by targeting PARP14 and SARS-CoV-2 domains involved in ADPr during infection. By seeking to unravel the molecular details of PARP14-catalysed ADPr, UbADPrLINK has the potential to advance our understanding of ADPr signalling beyond the state-of-the-art and may contribute to the development of new therapies.

Keywords: adp ribosylation,parp14,post translational modification ptm,ptm crosstalk,ubiquitylation,dna damage,antiviral immunity,sars cov 2,structural biology,biochemistry,proteomics,drug discovery
Effector-Guided Engineering for Crop Resistance (PREDESIGNX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1499985.0
EU funding (EUR): 1499985.0
Participants: 1
Project status: SIGNED

PREDESIGNX aims to revolutionize crop protection strategies by developing a comprehensive pipeline for engineering durable disease resistance in Solanaceous crops. This ambitious project integrates advanced computational predictions, synthetic biology, and translational research to reduce pathogen-caused losses. The project is structured around three interconnected work packages: 1. TARGET: Predict effectors and identify their host targets using advanced computational tools and large-scale genomic data. Validate predictions with high-throughput experimental approaches in planta. 2. BIOENGINEERING: Explore natural domain integrations in well-characterized NLR systems, including Pik and Solanaceous NRC sensors. Engineer NLR receptors with altered recognition specificities using rational design principles guided by structural biology and evolutionary analysis. 3. RESISTANCE: Apply bioengineered NLRs to crop protection, focusing on potato. Generate and evaluate transgenic potato lines expressing promising engineered NLRs against important pathogens. PREDESIGNX represents a significant advance in plant immunity and crop protection. By focusing on natural host protein domains and multiple NLR scaffolds, the project aims to develop a generalizable framework for engineering disease resistance in crops. This approach promises durable resistance while potentially simplifying regulatory pathways. The insights gained will advance our understanding of plant-pathogen interactions and provide innovative tools for crop improvement. By spanning computational biology, synthetic biology, and evolutionary analysis, PREDESIGNX has the potential to significantly impact global food security by providing new strategies for protecting key crops against devastating diseases. Furthermore, this project will yield fundamental insights into pathogen virulence strategies and the evolutionary dynamics of NLR-integrated domains, revealing the molecular arms race between plants and pathogens.