Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nutricosmeceutical valorization of Porphyra/Pyropia spp. (Rhodophyta): biorefinery approach in the frame of Blue Economy (NUVAPY-BLUE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

Nutricosmeceutical develops products to improve health through the use of bioactive compounds (BACs). Algae are organisms that have a wide variety of BACs, high productivity and can be produced without irrigation or arable land. Following EU Green Deal and Blue Economy, the proposal aims to increase the macroalgae Porphyra/Pyropia productivity in consortium with fish, to produce high value BACs naturally and make nutricosmeceutical more attractive to the market. To reach this objective, the project will focus in: Porphyra production on a large scale using integrated multitrophic aquaculture with fishpond effluents from Chelon labrosus for alga growing, optimizing natural production of BACs; extract and purify BACs through biorefinery strategy; perform BACs encapsulation and test their sun protection, stability, toxicity, bioavailability; and develop topical and oral sunscreens. Researches shows some abiotic factors for BACs development and production in Porphyra, however there is a lack of studies that correlate various abiotic factors along with fish culture for a circular economy and better algae development. The project will produce biofertilizers and biostimulants from residual algal biomass, after extractions, which has not yet been optimized. Natural sunscreens are still scarce on the market, due to the lack of standards in extracts with stability for use in products and low BACs availability. The project’s interdisciplinarity is strong involving aquaculture, biochemistry, biotechnology and nutricosmeceutical. This 24-month long proposal includes both the transfer of knowledge to the host institution and the researcher’s training in new techniques. Furthermore, this project will place the researcher and the host institution in a leading role on natural production of Porphyra and BACs with emphasis in nutricosmetical industry. It will make the researcher more employable and competitive in applying for future roles, continuing in academic and/or industrial area

Keywords: bioactive compounds,algae,nutraceutics,sunscreens,integrated multitrophic aquaculture
Functionalisation of Propellanes and Bicycloalkanes using Multicomponent Reactions (MultiProp)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Project MultiProp aims to advance the field of synthetic organic chemistry by exploring the use of small-ring propellanes in multicomponent reactions (MCRs). Radical ring-opening reactions of these propellanes lead to bicyclo[n.1.1]alkanes (BCAs), which are sp3 rich "cage" hydrocarbons that are of high interest in drug design. Specific examples include bicyclo[1.1.1]pentanes (BCPs), which have demonstrated to be bioisosteres of para-substituted benzene rings, alkynes, and tert-butyl groups; and bicyclo[3.1.1]heptanes (BCHeps), which have proved to be potential meta-arene analogues. Molecules incorporating these rigid scaffolds typically exhibit enhanced pharmacological properties compared to their parent structures, such as improved solubility and reduced metabolic susceptibility, while preserving their three-dimensional configuration. Despite the utility of BCAs in medicinal chemistry, their synthesis using multi-component reactions is underdeveloped. This proposal aims to address this gap by developing novel methodologies for the application of propellanes in diverse multicomponent chemical processes, thereby streamlining access to functionalised BCAs. The project comprises three Work Packages: WP1: Developing new multicomponent protocols for the C–H functionalisation of organic molecules using propellanes as substrates, and the C–H functionalisation of bicycloalkanes. WP2: Applying Norrish type I and II photochemical reactions to propellanes, and related 1,5-hydrogen atom transfer / functionalisation reactions, for the synthesis of functionalised BCAs. WP3: Developing N-heterocyclic carbene-promoted MCRs using alcohols and propellanes as substrates, where NHC-activated alcohols serve as radical precursors for the synthesis of highly substituted BCPs and BCHeps. MultiProp thus seeks to expand the chemical space of propellane-derived molecules, opening new avenues for their applications in synthetic organic chemistry, medicinal chemistry, and materials science.

Keywords: bioisosteres synthesis,multicomponent reactions,small rings,propellanes,bicycloalkanes
Social Media Artistic tRaining in Teenagers (SMART)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United States,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-05-01
End date: 2026-10-31
Duration (months): 42.0
Total project cost (EUR): 302708.88
EU funding (EUR): 302708.88
Participants: 4
Project status: TERMINATED

SMART is at a novel intersection between cognitive developmental neuroscience, neuroeducation, mobile health promotion, human brain connectivity, and art appreciation & creation fields. The motivation behind SMART is, first, the increase in usage of smart devices/social media platforms (SM), paired with a reduction in the age of first exposure to these platforms; and second, the focus of neuroscientific research on negative effects of their overuse, despite the evidenced positive influences that SM hold (boosting social interaction, creativity, health promotion). Reported negative influences include alterations on executive functions, cognitive & emotional control, and an increased risk of developing depression and anxiety throughout adolescence/adulthood. Nevertheless, effects of overuse of SM during development are influenced by different factors, with the type of activities/interactions playing a crucial role. SMART’s main goal is to apply art-related interventions to transform the use of SM by adolescents, while seeking to overcome the negative implications linked to the excessive ‘passive’ use of these platforms, at brain, cognitive & mental health levels. Art-based interventions have previously proven to strengthen the same brain networks and functions most frequently impaired due to SM passive overuse. Our artistic interventions will engage participants in more stimulating/intellectual SM activities, reducing the passive overuse, and potentially promoting cultural practices that reduce overall use/dependency of SM. Novelty is granted by using a digital art creation approach (no classical art training), involving daily used devices & motivating environments, and the combination of multimethodological data to study the brain mechanisms behind potential cognitive & emotional changes induced by the interventions. Conclusions from SMART may promote artistic activities/professions, inspire education programs and policy, and be applied to improve academic outcomes.

Keywords: brain connectivity adolescents cognition emotion neuroprotection social media artistic trainings music intervention visual arts intervention cognitive control mental health transfer effects
Investigation of coupled bone and eggshell (de)mineralization during laying cycle of hens (BonEggHens)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 3
Project status: CLOSED

Skeletal disorders in laying hens are a major concern for the food industry. It is well recognized that bone demineralization in laying hens is coupled to the daily mobilization of Ca for egg formation but the relation between bone properties and eggshell quality is still unclear. A key point for understanding this coupled process is reveling the factors that influence bone dissolution since the unbalance between resorption and formation is what causes bone diseases such as osteoporosis and osteogenesis imperfecta. Notably, there is limited information on how the composition, structural organization and interaction between bone mineral phase and organic matrix in different bone types influence chicken bone dissolution and its mechanical properties. BonEggHens aims to perform a systematic study, from macro to nanoscopic scale, on a large array of bone and eggshell samples representative of the hen’s life cycle, to assess i) the effect of the mineral labile phase and the organic matrix on bone dissolution, ii) the relation between micro and nanoscopic characteristics of hen’s bones to bone quality parameters (e.g., bone density, mineral crystallinity) and iii) the correlation between bone structural and compositional changes and eggshell quality. The results of the proposed study will shed light on bone/eggshell (de)mineralization processes, which will help to find solutions for a more sustainable yet productive farming system for ovo-production. Moreover, the outcome of BonEggHens has potential implications for future biomineral investigation by cutting-edge microscopy tools and, most importantly, for the study of human bone diseases resembling those in chickens. Finally, the development of the proposal will be career-defining, contributing to the professional and personal growth of the experienced researcher and providing the necessary skills and competences to increase her competitiveness and attain a permanent position in the European scientific framework.

Keywords: geochemistry,biominerals,dissolution,skeletal disorders,animal welfare,tem,micro raman,atom probe tomography,atr ftir
Acceleration of the world’s first autotaxin inhibitor for the treatment of pancreatic cancer (PDAC) (CURE-PDAC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-10-01
End date: 2025-03-31
Duration (months): 30.0
Total project cost (EUR): 5906503.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

iOnctura is a clinical stage biopharmaceutical company dedicated to delivering innovative cancer treatments to patents with unmet medical needs. iOnctura’s unique pipeline of drugs unlock mechanisms at the tumour-stroma-immune (T-S-I) interface, a multi cell-network that is responsible for driving tumour growth and survival as well as treatment resistance. Pancreatic cancer is one of the most lethal cancers associated with devastating impact on the quality of life of patients; current treatments are largely ineffective and there is a need for game-changing therapies. IOA-289, is a first in class autotaxin (ATX) inhibitor that tackles cancer growth and spread by affecting core mechanisms at the T-S-I interface. The EIC Accelerator funding for CURE-PDAC will allow iOnctura to accelerate the clinical development of IOA-289 as a treatment for pancreatic cancer through Phase I/II clinical trials, reach a major value inflection point and attract further financial investment into the company.

Keywords: health,oncology,drugs,pancreatic cancer,immunotherapy,fibrotic disease,clinical development,pharmaceutical industry
QUARC-BEYOND QUANTUM ADVANTAGE: A PRACTICAL AND UNCONDITIONAL PERSPECTIVE (QUARC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-23
End date: 2025-01-22
Duration (months): 26.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

In this project I will develop techniques and tools to demonstrate unconditional and practical quantum advantage. The quantum speedups that have been developed so far are mostly based on certain assumptions from complexity theory, or they are established relative to imaginary back boxes, called oracles, that are assumed to perform certain tasks and implement certain operations on input data. I will design problems that can demonstrate quantum advantage without such assumptions. The tools and techniques that will be developed in this project can have a wide range of applications in other disciplines, in particular, I will export tools and algorithms from theoretical quantum computation to more practically relevant applications in machine learning and cryptography. I specify concrete objectives that address important gaps in the development of quantum advantage. I design work packages to systematically implement my envisaged approaches and methods. I will bring my expertise from quantum information and incorporate it in quantum effects and computation to reach my goals. I clarify the role of the fellowship in my career development towards establishing my own research group. I explain my approaches towards implementing this project in an impactful manner.

Keywords: quantum advantage,unconditional proofs,practical quantum algorithms,non oracular designs
WAterborne fedeRated systems and models for secuRe and resilieNt operations (WARRaNT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Countries involved: Belgium,Norway,Germany,Netherlands,Spain,Greece,Cyprus,Switzerland
Call: Ensuring the safety, resilience and security of waterborne digital systems (HORIZON-CL5-2024-D6-01, 2024)
Start date: 2025-04-01
End date: 2028-03-31
Duration (months): 36.0
Total project cost (EUR): 4251557.5
EU funding (EUR): 4251557.5
Participants: 14
Project status: SIGNED

The WARRaNT project will enhance the dependability, safety, security, and resilience of Waterborne Digital Systems (WDS) and Safe, Secure, and Resilient Operations of Digitalized Ships (SRODS). Leveraging advanced methodologies, the project integrates hazard and risk management with human factors, cybersecurity, and resilience across all ship subsystems and interactions with infrastructure. WARRaNT employs Digital Twin technologies and Knowledge Graphs (KG) to support continuous monitoring, fault simulation, and testing, enabling real-time, predictive maintenance and decision-making. The project also focuses on transferring best practices from other safety-critical industries, such as aerospace and automotive, to the maritime sector. The methodology will be validated and refined through Living Labs, which serve as experimental environments designed to ensure the methodology meets real-world operational needs. To this end, WARRaNT establishes four distinct Living Labs, each focused on a specific aspect of enhancing system reliability: LL1 targets dependable containership digital systems, LL2 focuses on robust smart container-ship connectivity, LL3 addresses resilient automation systems for autonomous green vessels, and LL4 concentrates on the enhanced dependability of remote operation systems. WARRaNT also emphasizes industry adoption by providing tools and a Knowledge Platform for stakeholders, promoting standardization and the secure, federated sharing of data and models. This comprehensive approach positions WARRaNT as a key enabler for the future of autonomous, green, and resilient maritime operations.

Keywords: dependability,cybersecurity,waterborne,digital,autonomy,resilience,safety,resilience,interoperability,hazop,living labs,knowledge graphs,federated learning
Evaluation of Autism SpEctrum Disorder in children with Cerebral Palsy (EASED-CP) (EASED-CP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2027-03-31
Duration (months): 54.0
Total project cost (EUR): 330428.88
EU funding (EUR): 330428.88
Participants: 3
Project status: SIGNED

Cerebral Palsy (CP) is the most common physical disability in childhood and Autism Spectrum Disorder (ASD) is one of its most common and impactful comorbidities. Proper identification of ASD in CP is clinically important but state-of-the-art diagnostic methods rely on behavioural symptoms that overlap with the motor and speech difficulties seen in CP. This makes ASD diagnosis very challenging and limits the validity and usability of standardized clinical instruments. Consequently, some children with CP go undiagnosed and without important support for their ASD. Others can be falsely diagnosed by, for example, being physically unable to complete assessments. This has detrimental effects and results in resource misallocation. EASED-CP will establish the next-generation gold-standard clinical tools for assessment of ASD symptoms in CP. Current clinical and research practices for ASD assessment in children with CP will be reviewed and experts surveyed. Consensus clinical guidelines and an adapted standardized instrument for ASD assessment in CP will be co-developed though a Delphi process, implemented, and tested. This will be enabled by a cross-cultural international collaboration of pioneers in ASD (University of California San Francisco, outgoing phase), CP (University of Barcelona, return phase) and instrument validation (Hogrefe TEA Ediciones, placement). My current clinical and research expertise in the psychological characteristics of children with CP, interdisciplinary profile and previous success building international collaborations makes me the perfect fit to lead this project. Through EASED-CP I will connect with a broad international expert network and develop a unique collection of expertise. This includes completing exceptional-quality training in test-building methods and ASD assessments. Overall, the cooperation of these leading research centres is expected to have a tremendous impact on the understanding and diagnosis of ASD in CP.

Keywords: cerebral palsy autism spectrum disorder disability diagnosis standardised instruments guidelines consensus differential diagnosis
Brain Interchange ONE SR—the implantable neuromodulation technology for stroke rehabilitation (BIC ONE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 3675427.5
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Electrical brain stimulation has been successfully used since the 1990s to treat neurological illnesses, particularly movement disorders. Most of the devices for this novel approach are based on the old pacemaker technology. Companies are unwilling to take device development risks & rely on established tech, limiting new therapy developments. Many neurological diseases are still treated with pharmaceuticals only, which has limited effectiveness and causes severe side effects. Neuromodulation—electrical stimulation research has increased in recent decades. Additional recording capabilities & closed loop therapy expand therapeutic options. CorTec aims to provide novel implantable tech to overcome the current limitations: it enables researchers, medical institutions & industry to develop new therapies & devices. We plan to finalise the development of our tech for stroke rehabilitation, conduct clinical trials & get market approval in 2029, generating €250M in sales in 2030.

Keywords: therapy development,stroke rehabilitation,rehabilitation,plasticity,personalised treatment,neurological disorder,neurodegenerative diseases,neuromodulation,computational neuroscience,neuroimaging,micro system engineering,central nervous system,ai
Melt-Spun Amorphous Drug Systems for Enhanced Pharmaceutical Efficacy (DRUG-SPIN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-04-01
End date: 2027-09-30
Duration (months): 18.0
Total project cost (EUR): 197544.96
EU funding (EUR): 197544.96
Participants: 1
Project status: SIGNED

Half of the globe’s population takes at least one drug a day. Since 90% of currently developed drugs exhibit poor water solubility, leading to exceeding amounts of drugs being consumed and unprocessed drug ending up in waste water. This project aims to address the challenge of poor water solubility in pharmaceuticals, improving the drug’s efficacy and patient compliance. By converting crystalline drugs into their amorphous forms, the solubility is known to increase by a large factor. However, based on the strategy for to obtain the amorphous form, drugs are more or less stable and crystallize in storage. This project will adapt an established method from materials science, melt-spinning, rapidly quenching molten drugs on a spinning copper wheel to achieve reproducible, high cooling rates and perfectly stabilize the amorphous state. The project has four key objectives. First, a melt-spinning device will be set up for drug quenching. This will involve designing and building the necessary equipment to achieve controlled quenching rates. Next, the project aims to produce amorphous drug particles or films, exploring the relationship between quenching rates and drug stability. The third objective is to characterize the stability and solubility of these amorphous drugs using advanced analytical techniques such as spectroscopy, calorimetry, and diffraction methods. Finally, the solubility and stability of these amorphous drugs will be assessed over an extended period. The project is expected to significantly advance the understanding of amorphous drug formulations, potentially leading to more effective and stable drugs. This research will contribute to reducing pharmaceutical waste and improving patient compliance, aligning with global sustainability goals. Furthermore, the fellowship will enhance my career prospects by providing expertise in pharmaceutical technology, thereby bridging the gap between materials science and life sciences.

Keywords: pharmaceutic technology pharmaceutic processes