Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
“EEG-based DIagnosis Support solutiON” (EDISON) to help close the epilepsy diagnosis gap in Low- and Middle-Income Countries (LMICs) by combining low CAPEX and AI-guided capture with telemedicine (EDISON)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-06-01
End date: 2025-02-28
Duration (months): 33.0
Total project cost (EUR): 3022110.0
EU funding (EUR): 2078428.0
Participants: 1
Project status: CLOSED

About 40M people in low- and middle-income countries (LMIC) suffer from epilepsy-related seizures but not all are diagnosed and treated due to the lack of electroencephalogram (EEG) devices and neurologists in these regions. BrainCapture (BC) is developing an EEG-based diagnosis service (BrainCap) for epilepsy and other neurological disorders that fits LMIC needs since it is affordable, uses mobile phone infrastructure and does not need an EEG expert on-site for data capture due to an AI-based Quality Control (QC) algorithm. Data is analysed by remotely placed neurologists who provide a diagnosis and treatment plan via the BrainCap app/cloud. Our field trials revealed that there is a clinical need for BrainCap. Now, we will finish the product design, optimize the QC algorithm, and extend clinical validation to multiple sites to convince KOLs in several primary markets. The EIC investment will be key to create EEG market in LMICs, leveraging a significant business opportunity for BC.

Keywords: neurological disorders,epilepsy,epilepsy treatment gap,telemedicine
Small RNAs in immunity and regulation of giant endogenous viral elements in eukaryotes (SMALLGIANT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

In this project, we aim to investigate the role of small RNAs (sRNAs) in defending against giant virus infections. Giant viruses are eukaryotic viruses with exceptionally large genomes, some of which surpass the size of bacterial genomes. Remarkably, giant virus integrations have been found across various eukaryotes, leading to the formation of giant endogenous viral elements (GEVEs). Among the reported GEVEs, the host group (Dr. de Mendoza’s laboratory) has identified a unicellular relative of animals that harbours hundreds of GEVEs—more than any other known eukaryote. This observation suggests that these viral integrations may confer a beneficial role to the host. Although GEVEs are typically transcriptionally silent, the removal of DNA methylation triggers the reactivation of many viral genes, mimicking an infection. Notably, proteins related to sRNA biogenesis are upregulated during this reactivation, indicating that sRNAs may play a role in post-transcriptional silencing of the endogenized viruses, as no viral particles are formed. Based on these findings, we hypothesize that GEVE-derived transcripts generate sRNAs that help defend against future infections.To explore this hypothesis, I will bring my expertise in small RNAs to the host lab, aiming to deepen our understanding of how sRNAs co-evolved with GEVEs and how they may function in immunity against giant viruses. My focus will be on key unicellular eukaryotes that possess the genetic machinery necessary for sRNA processing and show evidence of containing GEVEs. The outcomes of this project have the potential to open a new field of research. If sRNAs are indeed involved in immunity, they could be leveraged to protect these species against new infections. Additionally, we propose various outreach activities to engage the public and highlight the importance of studying the evolution of unicellular eukaryotes and giant viruses.

Keywords: transposable elements,noncoding rna,repetitive dna,protists
D-MIMO Multi-band Imaging for 6G Framework (MIDAS-6G)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-29
End date: 2028-01-28
Duration (months): 24.0
Total project cost (EUR): 252180.0
EU funding (EUR): 252180.0
Participants: 1
Project status: SIGNED

The MIDAS-6G project aims to seamlessly integrate high-resolution imaging capabilities into the 6G infrastructure using a pioneering multiband distributed multiple input multiple output (D-MIMO) system. This innovative application enhances imaging resolution via large physical and frequency apertures without compromising communication functionalities, marking one of the first such integrations in the field. Structured around three key objectives, optimizing the D-MIMO system for high-resolution imaging capabilities, developing imaging techniques tailored for the D-MIMO 6G infrastructure, and investigating the synergies and trade-offs within an Integrated Communication and Imaging (ICAI) framework, the project is methodically aligned with distinct work packages. This alignment ensures a systematic approach from the initial system design, which utilizes heuristic and convex optimization methods, to the advanced development of imaging techniques using nonlinear compressed sensing and Bayesian methods, culminating in the robust implementation of ICAI. Interdisciplinary expertise from fields such as electromagnetic theory, compressed sensing, and wireless communications is leveraged to enhance the system's capabilities, creating a dynamic collaborative environment that drives technological innovation. Performance is rigorously evaluated through detailed simulations, with metrics such as resolution, signal-to-noise ratio, signal-to-interference-plus-noise ratio, and bit error rate serving as indicators of success. The anticipated outcomes include the development of novel, scalable imaging technologies well-positioned for dissemination across academic and industrial sectors, and enhancing urban safety and autonomous navigation. By integrating high-resolution imaging solutions with cutting-edge 6G technology, the MIDAS-6G project is set to transform technological standards, delivering significant benefits across various sectors.

Keywords: 6g wireless communication
Soft Enforcement of EU Migration Law (SoftEn)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

This project will establish soft enforcement of EU migration law as a new research field in which legal and political science scholars will be equally active. Migration is a salient issue for the EU, and we are witnessing deep shifts in the implementation and enforcement landscapes of EU migration law. Traditional enforcement methods, such as Court of Justice proceedings initiated by the European Commission against Member States, have met their limit. Soft enforcement is becoming a flexible and politically palatable alternative. For example, Fundamental Rights Offices have been established within EU migration agencies that operationalise novel Ombuds-type administrative accountability processes, and a peer review mechanism, run jointly by the Commission and Member States, has been integrated with the Schengen area of free movement. SoftEn conceptualizes soft enforcement and unlocks the black box of its operationalisation in the context of migration. It brings together theoretical insights from legal and political science on governance, enforcement, and accountability, combining legal analysis with empirical qualitative methods. Its groundbreaking nature lies in three characteristics. First, the project will generate a new interdisciplinary, legally grounded and empirically informed theory of soft enforcement in the migration context. Second, it will generate datasets on soft enforcement along three axes (steering policy implementation; supervising policy implementation; and ensuring actor accountability) across the EU’s migration policies. Moving beyond ‘law on the books’, it will also generate unique qualitative empirical insights at EU and selected national levels. Third, it will generate a new evidence-informed governance framework for soft enforcement that can impact the work of public institutions at EU and national levels, and ultimately, individuals.

Keywords: european union eu law eu migration law eu asylum law eu law enforcement fundamental rights administrative governance multi level governance accountability
Twisted nanophotonic technology for integrated chiroptical sensing of drugs on a chip (TwistedNano)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Germany,France,Spain,Switzerland,Cyprus
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-04-01
End date: 2026-07-31
Duration (months): 52.0
Total project cost (EUR): 3679925.0
EU funding (EUR): 3679925.0
Participants: 10
Project status: SIGNED

The quest for new medical drugs demands reliable, ultrasensitive and fast techniques to identify, refine and test small volumes of candidates for clinical trials. The efficacy of pharmaceuticals depends to a large extent on their chiral composition, and thus enantiomeric purity and selectivity is an important issue for the development of new drugs and to test their biotoxicity. TwistedNano addresses this need with a new generation of integrated nanophotonic devices enabling ultrasensitive chiroptical spectroscopy of sub-nanolitre volumes, revolutionizing at-source the sensing technological toolbox for drug discovery and nanomedicine. Because of governmental regulations, agencies require pharmaceutical manufacturers to investigate systematically most of drug enantiomers to determine their safety/efficacy. Thus, the development of fast, compact and accurate chiral sensing on a chip is one of the current primary targets of the nanomedicine industry, constituting a growing market that is already exceeding 100 billion Euros. TwistedNano will result in a photonics-enabled chiral sensing technology that integrates vectorial structured light fields with almost arbitrary control onto a microfluidic chip, providing groundbreaking advantages compared to current instrumentation: (i) remote/distributed analysis, (ii) reduced sample consumption, (iii) cost reduction, (iv) parallelization, (v) increased diagnostic speed and sensitivity. Key elements developed for optofluidic integration include photonic crystal fibers, photonic nanostructures, and metasurfaces operating in close synergy with cutting-edge chiroptical spectroscopic techniques. In the mid-term, TwistedNano will not only lay the foundations of a new lab-on-chip chiral sensing technology revolutionizing drug discovery, theranostics and nanomedicine, but also open a plethora of disruptive applications such as characterization of minute amounts of viruses and macromolecules in general.

Keywords: chiral spectroscopy,enantiomers,nanophotonics,radiation matter interaction,photonic crystal fibers,nonlinear optics,microfluidics,lab on a chip,nanomedicine
Metabolomics InveStigation of cyStic fIbrosis pulmOnary exacerbatioNs (MISSION)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: CLOSED

Cystic fibrosis (CF) is a lethal genetic disease affecting 1 out of 2500 newborns. In CF patients, compromised innate immunity enhances the susceptibility to colonization of lower airways by different microbes, leading to long-term bacterial infections. Data suggests that the resulting host-pathogen interactions can shape the course of disease progression, but this relationship is still poorly understood. I propose to use CF patients' samples of exhaled breath condensate to investigate intra-microbial interactions and host-responses, especially during pulmonary exacerbations (PEx), which are recurrent episodes of acute worsening of respiratory symptoms, adversely influencing patients' quality of life. Metabolomics (i.e., the exploration of small molecules within a biological system under defined conditions) has been acknowledged to be the omics discipline closest to the actual phenotype. Thus, I plan to use an unbiased metabolomics approach based on liquid chromatography-mass spectrometry to investigate the chemical environment of CF lungs, with the aim of reducing interpatient variability, characteristic of CF, to increase the generalisability of the findings. I will combine this approach with clinical information and cell biology techniques to test the immune response modulation in vitro, and shed light on the important roles played by metabolites present in CF airways in the regulation of host immune responses. Targeting the main hurdles in finding a cure for CF patients, namely the interpatient variability and the elucidation of the immunopathogenesis of CF, the expected results will give a necessary contribution to the understanding of CF mechanisms, that are still largely unknown. This knowledge is in turn fundamental to guide personalised clinical decisions for early intervention and amelioration of PEx treatment. To the best of our knowledge, there are not yet studies proposing a similar methodology to achieve such an ambitious goal.

Keywords: lc ms ms untargeted metabolomics cystic fibrosis host pathogens interactions
UPSCALING INNOVATIVE GREEN URBAN LOGISTICS SOLUTIONS THROUGH MULTI-ACTOR COLLABORATION AND PI-INSPIRED LAST MILE DELIVERIES (URBANE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Innovation actions
Countries involved: Greece,Belgium,Spain,Italy,Netherlands,Germany,Denmark,Norway,Finland,France,Czechia
Call: New delivery methods and business/operating models to green the last mile and optimise road transport (HORIZON-CL5-2021-D6-01, 2021)
Start date: 2022-09-01
End date: 2026-02-28
Duration (months): 42.0
Total project cost (EUR): 10000945.25
EU funding (EUR): 8783042.88
Participants: 43
Project status: SIGNED

URBANE brings together a multidisciplinary group of 41 partners from 12 different EU Member States, including 12 cities, industry leaders in logistics services, novel solution providers for shared, connected and automated operations and research experts to co-develop novel last mile delivery solutions combining green automated vehicles and shared space utilisation models. The project will support the transition path towards effective, resilient, safe and sustainable last mile transport, through four Lighthouse Living Labs (Helsinki, Bologna, Valladolid and Thessaloniki, that will demonstrate TRL7/8 efficient, replicable and socially acceptable innovative last mile delivery solutions (Wave 1 LLs), building on existing TRL>5 assets. Hands-on lesson learning at European level will be primarily facilitated by an Innovation Transferability Platform comprising Digital Twinning Tools, open models, smart contracts governed by blockchain technology and a data-driven Impact Assessment Radar that will enable the adaptation and replication of Wave 1 solutions in two Twinning LLs in Barcelona and Karlsruhe (Wave 2 LLs), demonstrating their own solutions within the course of the project. URBANE’s commitment to upscaling is further strengthened by the engagement of six early adopters (Follower Cities) in innovations’ adoption feasibility studies, thus stimulating the formulation of new LL communities across Europe. The approach employs social simulation tools to experiment with possible strategies. URBANE will provide evidence of the real introduction of the Physical Internet in urban deliveries for the first time.

Keywords: digital twin,physical internet
INCREASED FLEXIBILITY OF ATCO VALIDATIONS – V3 (IFAV3)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Germany,Netherlands,Spain,Sweden,United Kingdom,Italy
Call: Industrial Research & Validation for Master Plan Phase C Capacity-on-Demand and Dynamic Airspace (HORIZON-SESAR-2022-DES-IR-01, 2022)
Start date: 2023-07-01
End date: 2026-06-30
Duration (months): 36.0
Total project cost (EUR): 5442142.25
EU funding (EUR): 3809499.59
Participants: 13
Project status: SIGNED

Growing traffic numbers, environmental aspects and cost effectiveness issues create a huge demand on the Air Traffic Management to continuously optimize its processes and use of resources. One key resource is the availability air traffic controllers of the air navigation service providers. Due to current regulations and practices, the deployment of air traffic controllers to a specific airspace or unit is restricted by unit endorsements, as controllers have to be comprehensively trained on local procedures and circumstances. The research proposed in this project aims at enabling a more flexible deployment of ATCOs to sectors. This is a very wanted and eagerly awaited improvement in ATM, because it would improve its cost efficiency by Millions of Euros that could be saved yearly in the European Union. The concept behind increased flexibility of ATCO validations (IFAV) are various flexible endorsement strategies, that are based on technical enablers, like specific controller assistance systems that provide support on sector specific procedures and rules and/or procedural enablers, like for example ATC task standardization. Based on prequel SESAR solutions, like PJ.33-01a/b and PJ.10-73 IFAV, this new project will continue the IFAV work done in upper area control, and progress it to V3 / TRL6 maturity. This will be the main part of the project. In addition, about 15% of the project will be spent to transfer the know-how to another beneficial and similar use case: the application of IFAV in a remote tower centre. This project proposes two solutions that correspond to the described activities, and will include eight validation exercises. The consortium will consist of 13 partners: 5 ANSPs, 2 universities, 1 big industrial partner and 5 research organisations. Most of the partners were involved in prequel solutions PJ.33-01a/b and/or PJ.10-73 IFAV. DLR will act as project coordinator.

Keywords: ifav,unit endorsement,air traffic management,air traffic control,trl6,flexible endorsement
Workers’ Agency and Social Justice in the Age of Authoritarianism: Austria and Czechoslovakia, 1938–1989 (WORK-AGE-JUST)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 1
Project status: SIGNED

The project entitled “Workers’ Agency and Social Justice in the Age of Authoritarianism: Austria and Czechoslovakia, 1938–1989” develops a bottom-up perspective on workers’ engagement and promotion of social justice The project entitled “Workers’ Agency and Social Justice in the Age of Authoritarianism: Austria and Czechoslovakia, 1938–1989” develops a bottom-up perspective on workers’ engagement and promotion of social justice in the labour environment in Central Europe. Using and historically exploring the concepts of labour, social justice, and the welfare state, I will analyse how the notion of social justice was imagined in the workplace, how it circulated among and was communicated by workers during Nazism and Cold War and how the central European countries, such as Austria and Czechoslovakia, treated working conditions and labour relationships in the ‘age of extremes.’ The project aims to (1) explore employees’ understanding of social justice, (2) search for continuities and ruptures from Nazism to Cold War, and (3) bridge the conventional distinction between socialist Eastern and democratic Western Europe by studying institutionalized mechanisms of social justice in the work environment with respect to equality, rights, and labour safety. This is a topic full of relevance for our own times. Labour rights have come to the fore of political debate, in response to growing social inequality, and the impact of the Covid-19 pandemic.

Keywords: social justice,agency,labour,social rights,welfare state,trade unions,national socialism,cold war,communism,austria,czechoslovakia