Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Analysis Tool for Mesh Design of Leading Edge Design of Integrated Circuits (MeshAnalyzer)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: France
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

EDXACT (Electronic Design Automation: Extraction Analysis and Control Tools) is a software editor producing software tools that are necessary for the design of leading edge integrated circuits (IC). EDXACT is a supplier of Apple, Samsung, Huawei, Intel, AMD, TSMC and many other companies that supply the world with products containing advanced integrated circuits. The design of circuits with several tens of millions of transistors has become a normality over the last decade. The feature sizes of leading semiconductor circuits vary from 28nm downto 10nm and are extremely small. The design automation tools proposed by the oligopoly of the major suppliers of the market are lagging behind the technical possibilities. One of the most important aspects is the clock-design, where as much as 40% of design time could be saved by switching to modern tools. More importantly, by changing to a slightly different design approach and using a mixture of a clock-tree and clock meshes, today’s circuits could save energy by more than 35%. Unfortunately, no commercial tools exist today capable of analysing clock meshes correctly. Designers are limited to manual design and internal tools, which is limiting the use of this technology. We see an important market opportunity for EDXACT by combining our existing technology with existing tools and some intelligent glue in order to create the sought-after mesh analysis tool. Being in direct competition with the leaders of the market, we intend to progressively displace the usage of the monopolistic tool for timing analysis. Phase 1 of the project will put in place the prototype, including documentation and marketing material, finalize an official partnership with two leading IC manufacturers, and will clarify the business plan for this interesting technology.

Keywords: design automation,integrated circuits,nanometer circuits,wireless,reduction of energy consumption
Creating transformation-stable microstructures through shared crystallographic motifs (TRANSFORMERS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

While we continue to develop alternative and renewable power sources, the capture and sequestration of CO2 from flue gas in fossil fuel power plants and other industrial processes is one viable solution to decrease our CO2 emissions. CO2 can be removed from flue gas by chemical looping, where a material chemically reacts with CO2 and is treated at a later stage to release pure CO2 and regenerate the starting material. Limestone, CaCO3, is the oldest material to be used for this purpose. However, although limestone is abundant and cheap, the CO2 absorption capacity rapidly decays with use because of undesirable changes to the microstructure. The proposed work will prepare and investigate novel ternary metal oxide ceramics designed to be mechanically stable after repeated thermal and CO2 cycling. In particular, the proposed work will determine whether similarities in the crystal structures of materials (the atomic scale) before and after a transition will lead to robust microstructures (the micro scale) that will retain functionality – in this case, high porosity and CO2 sorption capacity. The complex crystal structures, rich phase space, and strong bonding networks available in ternary phases to be studied will lead to materials that are less prone to degradation. This evolution will be studied at the atomic level using in situ spectroscopic techniques, and the microstructure evolution will be studied using novel in situ X-ray tomography methods, which allow the 3D visualization of the microstructure in real time as the chemical transformations take place. These new approaches to material design will be immediately relevant to many other scientific fields where chemical transformations and mechanical stability are important, such as battery electrodes, solid oxide fuel cells, solid ion conductors, and catalyst supports, all of which suffer from performance loss over time due to microstructure changes.
From Omics to Patient: Improving Diagnostics of Pathogenic Yeasts (OPATHY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Ireland,Germany,Germany,Spain,Spain,Belgium,Netherlands,Netherlands,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-09-01
End date: 2019-08-31
Duration (months): 48.0
Total project cost (EUR): 3319305.84
EU funding (EUR): 3319305.84
Participants: 10
Project status: CLOSED

OPATHY is an innovative translational research training network that will explore the potential of omics technologies, including genomics, transcriptomics and proteomics, to study the interactions of yeasts that cause disease to humans (e.g. Candida and Cryptococcus sp.) with their host, and to develop new diagnostic tools to monitor yeast infections in the clinic. Today, these infections are poorly understood, difficult to diagnose, and are becoming increasingly frequent and serious, affecting over 300 million people worldwide. OPATHY will exploit omics technologies to investigate host-pathogen interactions during yeast infection and colonization with a primary focus on their potential to develop innovative diagnostics tools to improve health care. For this proteomics, transcriptomics and genomics measurements of strains and infections will be integrated with state of the art computational analyses to identify novel biomarkers able to determine the infection stage, the infective pathogen, and the potential resistance traits. This knowledge will drive the development of diagnostic tools based on the detection of specific DNA sequences (by PCR) or antibodies (by Elisa or proteomics). These tools will be validated in a clinical study of key patient cohorts. The participation of two clinical centers and four companies is of paramount importance for the network to provide an integrative and transversal research and training environment. Importantly, the methodologies and approaches of OPATHY can be easily extended to the study and identification of other human, animal and plant microbial pathogens, or the tracing of relevant industrial organisms. Grounded on solid individual research projects, OPATHY will train Early Stage Researchers in several scientific technologies and fields and transferable skills, to boost their careers as innovative and creative researchers.

Keywords: pathogenic yeasts,next generation sequencing,proteomics,omics,diagnostic,resistance,host pathogen interactions
Decision Support Tool for Rail Infrastructure Managers (DESTinationRAIL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Austria,Ireland,Switzerland,Norway,Croatia,Slovenia,Norway,Netherlands,United Kingdom,United Kingdom
Call: I²I – Intelligent Infrastructure (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 36.0
Total project cost (EUR): 3924800.0
EU funding (EUR): 2997000.0
Participants: 15
Project status: CLOSED

The project provides solutions for common infrastructure problems encountered in diverse regions of Europe, e.g. deterioration and scour damage to bridges, slope instability, damage to switches and crossings and track performance. Whilst similar failure modes are seen around the EU, the triggers (precipitation, earthquake loading etc.) are regional. The DESTination RAIL project will develop management tools based on scientific principles for risk assessment using real performance measurements and other vital data stored in an Information Management System. This will allow for a step-change in the management of European rail infrastructure. The objectives will be achieved through a holistic management tool based on the FACT (Find, Analyse, Classify, Treat) principle. Find - Improved techniques for the assessment of existing assets will be developed. Analyse- Advanced probabilistic models fed by performance statistics and using databases controlled by an information management system. Classify- The performance models will allow a step-change in risk assessment, moving from the current subjective (qualitative) basis to become fundamentally based on quantifiable data. Treat - The impact of proposed remediation or reconstruction will be assessed using the a probabilistic whole life cycle model which includes financial and environmental costs and the impact of work on traffic flow. The FACT principles will be implemented in a holistic decision support tool for infrastructure managers. DESTination RAIL will result significant impact in relation to the objectives of the work programme. It will reduce the cost of investment by using the IMS to manage the network, (ii) Monitoring and real-times analyses will prevent unnecessary line restrictions and closures. (iii) Lower maintenance costs by optimisimg interventions in the life cycle of the asset and (iv) optimise traffic flow in the network.

Keywords: infrastructure management,structural health monitoring,traffic model,information management system
The ubiquitin system in RAS-driven disease (UB-RASDisease)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2023-03-31
Duration (months): 60.0
Total project cost (EUR): 1999796.0
EU funding (EUR): 1999796.0
Participants: 1
Project status: SIGNED

The RAS pathway is the most frequently activated signaling node in human disease. Despite intensive efforts, effective therapeutic strategies for RAS-driven disease remain daunting. Elucidation of the mechanisms of RAS activation promises to lead toward novel therapeutic approaches to inhibit RAS activity, and may permit identification of patients who might benefit from RAS pathway inhibitors. Our preliminary studies show that reversible ubiquitylation controls RAS activity by altering its interaction network, thus representing a conceptually novel mechanism of RAS regulation. Our initial steps towards the understanding of the RAS ubiquitylation machinery have shown that positive regulators of RAS ubiquitylation are frequently mutated or down-regulated in RAS-driven diseases, whereas negative regulators are commonly up-regulated. These striking initial results suggest that dysregulation of RAS ubiquitylation may be an alternative mechanism that drives RAS activation in human disease. Here, we aim to elucidate the role of the ubiquitin system in RAS-driven disease. We will unravel the molecular machinery controlling RAS ubiquitylation and ascertain alterations of the identified machinery in RAS-driven disease. To assess the functional impact of these alterations, we will create genetically modified mouse models and CRISPR-engineered human cell models. We will employ cutting-edge proteomic approaches to determine how disease-associated dysregulation of RAS ubiquitylation perturbs RAS interactions and signalling. Using a synthetic biologic approach, we will obtain insights into mechanisms by which ubiquitylation modulates RAS interactions. It is significant that, in contrast to the majority of known RAS regulators, the ubiquitin enzymes are “druggable”, which implicates them as promising targets for inhibiting RAS activity. Thus, our studies could lead to new ways of defeating RAS-driven disease.

Keywords: post translational modifications
InSwitch – Ultra-Compact Electronic Solid-State Device for Induction Motor Starting and Performance Improvement (INSWITCH)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Portugal
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The proposed feasibility study respects to a project to develop, manufacture and commercialize worldwide of an ultra-compact, self-powered, electronic solid-state device for optimized soft-starting and steady-state performance improvement of fixed-speed three-phase squirrel-cage induction motors, by means of a novel automatic load-based stator winding connection-mode management technique. It also performs advanced motor protection and fault diagnosis. One of the most disruptive features of the proposed device is that it can be installed inside the motor terminal box. In can potentially be installed in more than 100 million of induction motors worldwide, replacing the obsolete electromechanical star-delta starters and compete with electronic soft-starters. From a conservative perspective, it is estimated that the World market for this device can reach 7500 M€/year in revenues, being an excellent business opportunity. Furthermore, the proposed technology is in line with the general trend toward solid-state solutions due to the inherent higher reliability. The device manufacturing will be outsourced, but the design and commercial exploitation will be fully managed by OptiSigma. “SME Instrument - Phase 1” funding will be used to produce a complete feasibility study in which the technical, economic, financial and commercial aspects are analyzed in detail, offering key information regarding the design, construction, certification, IP management, manufacturing and commercialization of the proposed product, as well as a market assessment in terms of dimension and risks. A detailed well-grounded business plan, SWOT analysis and a business model will be also included in the final feasibility report. The results will be used to prepare a proposal for “SME Instrument - Phase 2”, as well as to start private fund raising actions.

Keywords: cleantech,energy efficiency,energy savings,efficiency and power factor improvement,induction motor,motor starting,motor protection and fault diagnosis solid state electronic device
Understanding selective neuronal vulnerability in Alzheimer’s disease (NEVULA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2021-10-01
Duration (months): 36.0
Total project cost (EUR): 247059.0
EU funding (EUR): 247059.0
Participants: 2
Project status: CLOSED

The aim of this action is to understand the mechanisms behind the susceptibility of enthorinal cortex II (ECII) neurons to neurofibrillary tangle (NFT) formation in Alzheimer´s disease. To do so we will modulate the expression of the genes that according to NetWAS (Network-wide Association Study) are more directly involved in NFT formation in ECII neurons. Understanding why the pathological lesions that lead to neurodegeneration appear earlier in some specific neurons of the human brain is one of the major challenges in the neuroscience field. Prof. Greengard´s lab has generated a transgenic mouse that allows the immunoprecipitation of ribosome-bound mRNAs specifically from ECII neurons (ECII-bacTRAP mice). We will perform AAV stereotaxic injections in the enthorinal cortex of these mice followed by RNA-seq to determine how the modulation of our target genes affects ECII neurons expression profile. We will also explore whether our intervention can influence ECII neurons susceptibility to NFT in P301S AD mice. The results obtained in mice will be validated by immunofluorescence and in situ hybridization studies in human samples from control and AD patients at different Braak stages. Our results could add extremely relevant information on the mechanisms underlying AD pathogenesis and reveal these genes as new therapeutic targets for the disease.

Keywords: bactrap
Rapid absorption denaturalized collagen dressings (NATURALSKIN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-01-01
End date: 2019-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The World Health Organization and United Nations issued a warning statement on the world’s health in September 2011 on hard to heal wounds as 2-3% of world population is expected to suffer severe wound in life. Estimated cost of treating chronic wounds is between 2-3% of annual healthcare budgets (treatments and hospitalization). Essential part of the wound care treatment (after removal of devitalized tissue) is the use of dressings to promote autolysis and reduce microbial presence. EKOLBER has developed a rapid absorption linear (denaturalized) collagen made wound dressing (called NaturalSkin). This solution allows to improve dressings healing characteristics (due to rapid and complete absorption of the matrix) and reduction of dressing application times with a remarkable low price. Those improvements will contribute to reduce hospitals wound care costs and effectivity considerably. The advanced wound dressing market is an enormous and growing market because the number of patients suffering from hard to deal and chronic wounds. Main factors driving the appearance of this kind of wounds are the diabetes, cardiovascular diseases and the aging. Taking into account Natural Skins benefits, market needs and enormous existing market, a clear business opportunity for EKOLBER is outlined. In this Phase 1 project, a feasibility study will be held to analyse the viability of the whole project, analysing market, product, business and financial features in order to guarantee the profitability of the investment in the identified markets and future scenarios.

Keywords: collagen,dressings,wound,skin waste,circular economy,ulcer
Arctic Impact on Weather and Climate (Blue-Action)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Iceland,Germany,Germany,Germany,Germany,Spain,Italy,Switzerland,Norway,Finland,Korea, Republic of,Norway,China,Russian Federation,Finland,France,France,United States,Netherlands,Netherlands,Netherlands,Denmark,Denmark,Canada,Denmark,United Kingdom,United Kingdom,Faroe Islands,United Kingdom,Portugal,United Kingdom,United Kingdom
Call: Impact of Arctic changes on the weather and climate of the Northern Hemisphere (H2020-BG-2016-1, 2016)
Start date: 2016-12-01
End date: 2021-09-30
Duration (months): 58.0
Total project cost (EUR): 8103125.0
EU funding (EUR): 7500000.0
Participants: 50
Project status: CLOSED

Blue-Action will provide fundamental and empirically-grounded, executable science that quantifies and explains the role of a changing Arctic in increasing predictive capability of weather and climate of the Northern Hemisphere.To achieve this Blue-Action will take a transdisciplinary approach, bridging scientific understanding within Arctic climate, weather and risk management research, with key stakeholder knowledge of the impacts of climatic weather extremes and hazardous events; leading to the co-design of better services.This bridge will build on innovative statistical and dynamical approaches to predict weather and climate extremes. In dialogue with users, Blue-Arctic will take stock in existing knowledge about cross-sectoral impacts and vulnerabilities with respect to the occurrence of these events when associated to weather and climate predictions. Modeling and prediction capabilities will be enhanced by targeting firstly, lower latitude oceanic and atmospheric drivers of regional Arctic changes and secondly, Arctic impacts on Northern Hemisphere climate and weather extremes. Coordinated multi-model experiments will be key to test new higher resolution model configurations, innovative methods to reduce forecast error, and advanced methods to improve uptake of new Earth observations assets are planned. Blue-Action thereby demonstrates how such an uptake may assist in creating better optimized observation system for various modelling applications. The improved robust and reliable forecasting can help meteorological and climate services to better deliver tailored predictions and advice, including sub-seasonal to seasonal time scales, will take Arctic climate prediction beyond seasons and to teleconnections over the Northern Hemisphere. Blue-Action will through its concerted efforts therefore contribute to the improvement of climate models to represent Arctic warming realistically and address its impact on regional and global atmospheric and oceanic circulation.

Keywords: weather and climate prediction,long range,extreme weather,hazardous events,arctic,climate services,co design of services with end users,transdisciplinarity,innovation,societal engagement