Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The inherent morphological potential of the actin cortex and the mechanics of shape control during cell division (MORPHOCORDIV)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Cellular and Developmental Biology
Countries involved: United Kingdom
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2013-03-01
End date: 2018-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

The shape of animal cells is primarily determined by the cellular cortex, a cross-linked network of actin and myosin lying directly beneath the plasma membrane. Although it is increasingly clear that the study of cell mechanics is essential to understand cellular morphogenesis, the physical properties of the cortex are poorly understood. Our previous study on the mechanics of cytokinesis identified cortex tension, network turnover and cellular elasticity as key mechanical parameters controlling cell morphology. A physical description coupling cortex mechanics to cellular shape changes indicates that modulation of these three key parameters could be sufficient to induce a variety of morphological behaviors, including symmetric ingression of a contractile ring, cortex oscillations, and even asymmetric cell cleavage. The aim of this proposal is to reveal the intrinsic shape-generating potential of the cortex and to understand how this potential is used and controlled during cell division. To do so, we will first investigate how cortex tension, turnover and cell elasticity are controlled throughout division. We will test our understanding of cell shape mechanics by exploring how perturbing these properties affects the shape of the dividing cell. We will then explore whether cortical contractions can lead to asymmetric cytokinesis by attempting to induce differences in size between daughter cells by mechanical perturbations. Finally, we will use blebs separated from cells as model isolated cortices and investigate the control of shape dynamics in this simplified system. Our interdisciplinary approach will produce an integrated description of the mechanical function of the cortex in cell shape changes. More generally, I expect that this work will unveil some of the fundamental principles of cell morphogenesis by resolving how the coordinated regulation of a single set of physical parameters can unify seemingly disparate cellular morphogenetic events.

Keywords: actin cortex,cell mechanics,cytokinesis,asymmetric division,blebs.
Environmentally-induced Developmental Origins of Health and Disease (E-DOHAD)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: France
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2013-02-01
End date: 2018-01-31
Duration (months): 60.0
Total project cost (EUR): 1499870.0
EU funding (EUR): 1499870.0
Participants: 2
Project status: CLOSED

The DOHaD (Developmental Origins of Health and Disease) hypothesis states that, because of developmental plasticity, in utero and early postnatal stressors can increase chronic disease risk in childhood and later. Alterations of epigenetic marks, impacting on gene expression, are one mechanism that could explain such long-term impact. These hypotheses have so far been tested mostly in animals, and little for atmospheric pollutants, for which animal evidence is scarce. We aim to characterize the impact of environmental exposures on childhood health. Our focus is on two families of pollutants with a highly prevalent and controllable exposure in humans: atmospheric pollutants and specific high-volume non-persistent chemicals (Bisphenol A, other phenols and phthalates). These pollutants are archetypal of modern life pollutants challenging environmental health research. We will set up a new type of mother-child cohort with early recruitment in pregnancy, intense follow-up (including geolocalisation of subjects with GPS combined with fine-scale air pollution modelling), personal exposure monitoring, repeated collection of biological samples. Transcriptomic analysis, non-invasive clinical examinations (Doppler and ultrasound imaging, ECG, early postnatal evaluation of lung function) will bring clues regarding target functions. This observational approach in humans will be supplemented by an animal experiment aiming at characterizing the impact of in utero exposure to traffic-related atmospheric pollutants on foetal development and health in adulthood, and characterizing target functions and organs more finely than the human study can allow. E-DOHaD spans over the whole range of environmental health disciplines, with epidemiologic and toxicologic studies being conducted in parallel to ease comparability and results synthesis. E-DOHaD is expected to have far-reaching implications in environmental health research and for public health.

Keywords: air pollution,dohad,environmental health,phenols,phthalates,pregnancy
Implementation of Multi-scale Agricultural Indicators Exploiting Sentinels (IMAGINES)

Framework: FP7 — Cooperation
Programme: Space
Destination: Space-based applications at the service of the European Society
Action type: Collaborative project
Countries involved: France,France,United Kingdom,France,Hungary,Belgium,Belgium,Spain
Call:  (FP7-SPACE-2012-1, 2012)
Start date: 2012-11-01
End date: 2016-06-30
Duration (months): 44.0
Total project cost (EUR): 2854735.85
EU funding (EUR): 1998246.09
Participants: 9
Project status: CLOSED

The Copernicus Land Service is being built in the framework of the FP7 geoland2 project, which is setting-up pre-operational infrastructures. IMAGINES intends to ensure the consolidation and the continuity of the R&D efforts initiated in geoland2 to support the operations of the Copernicus Global Land Service, preparing the exploitation of the future Sentinel data in the Copernicus Operations phase beyond 2014. Furthermore, IMAGINES will favor the emergence of new downstream activities dedicated to the monitoring of crop and fodder production. The main objectives of IMAGINES are to (i) investigate the retrieval of multi-sensor and multi-scale biophysical variables (LAI, FAPAR, FCover, Albedo) in view to exploit Sentinel sensors data; (ii) develop qualified softwares able to process multi-sensor data at the global scale on a fully automatic and reliable basis; (iii) complement and contribute to the existing or future agricultural services by providing new data streams relying upon an original method to assess the vegetation above-ground biomass based on the assimilation of above-mentioned satellite products, using either regional or global Land Data Assimilation System infrastructures, in order to monitor the crop/fodder production together with the carbon and water fluxes; (v) demonstrate the added value of this contribution for a community of users acting at global, European, national, and regional scales. The added value of IMAGINES is to build a framework to perform the research and development activities needed for the evolution of the operational Global Land Service, in response to user needs and to new sensors, and to cover the whole chain of value from EO data to the final agricultural indicators directly readable by the end-users.The duration of the project is 40 months, starting in Autumn 2012, with 2 main phases for the definition, and development of demonstration products: first, using PROBA-V 333m data, as proxy of Sentinel-3, to generate hectometric products; then, using using PROBA-V & Landsat-8 (as proxy of Sentinel-3 & Sentinel-2) and Sentinel-1 data to generate multi-sensor decametric products.

Keywords: biosphere,environment,sustainability,agriculture,land monitoring,sentinels,assimilation,biomass,carbon flux
Combining innovation in vineyard management and genetic diversity for a sustainable European viticulture (INNOVINE)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: France,France,Spain,Portugal,Germany,Hungary,Italy,France,Bulgaria,France,France,France,Germany,Spain,Bulgaria,Spain
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2013-01-01
End date: 2016-12-31
Duration (months): 48.0
Total project cost (EUR): 8489665.0
EU funding (EUR): 5999990.0
Participants: 28
Project status: CLOSED

The strategic goal of the project is to help the European vineyard sector facing the increasingly global competition by meeting: * Consumer demands for diversified high quality wines and concerns for food safety * Citizens’ requests for environment-friendly production systems involving decreased or no use of pesticides and spare of not renewable natural resources * Producers’ needs of plant material, tools and methods to help them cope with the negative impacts of climate change while responding to demands for quality, environmental friendliness and needs of profitability To reach this overall goal, the project will: * At the plant level, improve and design agricultural practices (canopy management, irrigation, fertilisation, training systems, pest and disease control, etc.) aimed at maximising berry quality, durable resistance to pests and and diseases, and adaptation to climate change (higher CO2, drought, UV light, and higher temperatures) * At the vineyard level, design, develop and test innovative agronomic systems integrating new agricultural practices and taking into account the variability of constraints met by European vineyards grown under a wide range of environments * At the breeding level, diversify grapevine varieties with regard to desirable adaptative traits building on tools and knowledge developed through international breeding and genomic initiatives. The project will combine short, medium, and long-term approaches to respectively conceive innovative viticulture systems, design and test novel agronomic practices and decision support systems, and exploit the genetic diversity of grapevine that all together will ensure a progress towards sustainable viticulture.

Keywords: viticulture,sustainable practices,berry quality,biotic & abiotic stress,climate change,pesticides reduction,modeling,monitoring devices,decision support systems,genetic diversity
Pluridisciplinary study for a RObust and sustainabLe Improvement of Fertility In Cows (PROLIFIC)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: France,Denmark,Ireland,Spain,Netherlands,Sweden,United Kingdom,Spain,Denmark,Italy,Sweden
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2013-02-01
End date: 2017-01-31
Duration (months): 48.0
Total project cost (EUR): 5933631.58
EU funding (EUR): 2999531.0
Participants: 13
Project status: CLOSED

Intensive genetic selection in dairy cattle has resulted in a modern cows with very high milk yield but reduced fertility and poor calving performance. The sustainability of dairy cattle farming systems relies in large part on the ability of cows to maintain reproductive performance as they cope with the constraints imposed by environmental conditions and livestock practices. The strategic aim of this project is to unlock the potential for proactive herd management by providing the farmer with improved tools for on-farm reproductive monitoring and management. This will be achieved by a pluridisciplinary approach to eliminate the key scientific/methodological blockages and develop innovative solutions for a robust and sustainable improvement of fertility in cows. The project is structured in four R&D workpackages, one demonstration, one outreach and one management WP. The project will: 1) develop models to support on farm decision at different levels: animal fertility, herd management, and socio-economic impact for the farm and the farmer 2) identify genes and pathways involved in the adaptation of the reproductive function to different environmental conditions, especially low input feeding systems 3) identify the functional quantitative trait nucleotides for days till first luteal activity (based on progesterone measures) and estimate genomic breeding values using whole sequence information on individuals 4) study the adaptative response of animals to different feeding systems and management strategies 5) demonstrate the applicability of the knowledge and tools produced in the PROLIFIC project at the farm level 6) disseminate the knowledge produced in the project to the relevant stakeholders. PROLIFIC is a pluridisciplinary project taking advantage of the skills and expertise (modelling, molecular biology, genomics, phenotypic recording and statistics) of partners from all Europe. Seven research organizations, one industry and four SMEs are involved in the project

Keywords: dairy cows,reproductive performances,modelling,breeding strategies,fertility biomarkers,adipose tissue,genomic breeding values,nutritional management,milk analyzer,socio-economic impacts
Biopolymers from syngas fermentation (SYNPOL)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: Spain,United Kingdom,Germany,Ireland,Switzerland,Sweden,Germany,France,Spain,Belgium,Spain,Netherlands,Spain,Spain
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2012-10-01
End date: 2016-09-30
Duration (months): 48.0
Total project cost (EUR): 9939222.1
EU funding (EUR): 7344554.0
Participants: 16
Project status: CLOSED

SYNPOL aims to propel the sustainable production of new biopolymers from feedstock. SYNPOL will thereto establish a platform that integrates biopolymer production through modern processing technologies, with bacterial fermentation of syngas, and the pyrolysis of highly complex biowaste (e.g., municipal, commercial, sludge, agricultural). The R&D activities will focus on the integration of innovative physico-chemical, biochemical, downstream and synthetic technologies to produce a wide range of new biopolymers. The integration will engage novel and mutually synergistic production methods as well as the assessment of the environmental benefits and drawbacks. This integrative platform will be revolutionary in its implementation of novel microwave pyrolytic treatments together with systems-biology defined highly efficient and physiologically balanced recombinant bacteria. The latter will produce biopolymer building-blocks and polyhydroxyalkanoates that will serve to synthesize novel bio-based plastic prototypes by chemical and enzymatic catalysis. Thus, the SYNPOL platform will empower the treatment and recycling of complex biological and chemical wastes and raw materials in a single integrated process. The knowledge generated through this innovative biotechnological approach will not only benefit the environmental management of terrestrial wastes, but also reduce the harmful environmental impact of petrochemical plastics. This project offers a timely strategic action that will enable the EU to lead worldwide the syngas fermentation technology for waste revalorisation and sustainable biopolymer production.

Keywords: syngas. carbon monoxide. hydrogen. recombinant bacteria. fermentation. systems biology. building blocks. biopolymers.
Enhancing the BILATeral S&T Partnership with UKRraine * Advanced INnovative Approach (BILAT-UKR*AINA)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Bilateral coordination for the enhancement and development of S&T Partnerships
Action type: Coordination and support actions
Countries involved: Austria,France,Germany,Poland,Romania,Hungary,Ukraine
Call:  (FP7-INCO-2012-2, 2012)
Start date: 2012-09-01
End date: 2015-06-30
Duration (months): 34.0
Total project cost (EUR): 838089.84
EU funding (EUR): 749657.0
Participants: 10
Project status: CLOSED

The major objectives of BILAT-UKR*AINA are • to support the institutional dialogue on STI policy between the European Commission, the EU MS, CC and AC, and Ukraine, • to provide analytical input to the dialogue at the JSTCC and • to ensure practical follow-up and sustainability; Particularly, BILAT-UKR*AINA • foresees in a flexible manner pilot activities to facilitate the implementation of the joint EU-Ukraine STI Roadmap; • promotes RTDI cooperation opportunities to support the creation of networks and the participation in joint projects; • monitors and analyses innovation and research cooperation expressed in co-publications, scientific and educational networks and in terms of joint projects; • analyses, promotes and monitors the participation of EU researchers in Ukrainian S&T State Programmes; • secures the outreach of the project to interested parties who are not consortium members and • increases awareness about the assets of RTDI cooperation with Ukraine. The consortium is supported by the key stakeholders from the target country: the responsible Ministry, the State Agency, the National Information Point and the National Academy of Sciences - who are either project partners or members of the advisory board. Most partners have already cooperated in the preceding BILAT-UKR project and present herewith an Advanced INnovative Approach within BILAT-UKR*AINA.

Keywords: ukraine,sti policy,bilateral cooperation
BlueGenics – From gene to bioactive product: Exploiting marine genomics for an innovative and sustainable European blue biotechnology industry (BLUEGENICS)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: Germany,France,Portugal,Iceland,Italy,United Kingdom,Germany,France,Sweden,Croatia,United Kingdom,Switzerland,China
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2012-08-01
End date: 2016-07-31
Duration (months): 48.0
Total project cost (EUR): 8146397.0
EU funding (EUR): 5999869.0
Participants: 18
Project status: CLOSED

Marine organisms, in particular sponges and their associated microorganisms, are an inexhaustible source of novel bioactive (lead) compounds for biomedical application. Industrial exploitation of this natural resource using traditional approaches is, however, hampered, with a few exceptions, by unsolvable supply problems - despite of numerous efforts in the past. Therefore, there is, very likely, only one way: to start from the genes encoding the bioproducts, or their biosynthetic pathways, to sustainably obtain the active molecules in sufficient amounts. The aim of the presented industry-driven integrating project is to combine the knowledge in marine genomics, chemogenetics and advanced chemistry to produce recombinantly prepared novel secondary metabolite (lead) compounds and analogous from them, as well as pharmacologically active peptides, and to bring them up to the pre-clinical, and hopefully also to the clinical studies. This ambitious approach is based on breakthrough discoveries and the results of previous successful EU projects of members of the applying consortium, including European leaders (or worldwide leaders) in marine (sponge) genomics, metagenomics (polyketide synthase clusters), combinatorial biosynthesis and marine natural product chemistry/structure elucidation. This multidisciplinary project, driven by high-tech genomics-based SMEs with dedicated interest in bringing marine-biotechnology-derived products to the market, will also involve the discovery and sustainable production of bioactive molecules from hitherto unexploited extreme environments, such as hydrothermal vents and deep-sea sources, and the expression/scale-up of unique enzymes/proteins of biomedical and biotechnological interest. The molecular-biology-based strategies developed in this project for a sustainable exploitation of aquatic molecular biodiversity will further strengthen the international position and effectiveness of European (SME-based) blue biotechnology industry.

Keywords: marine bioactive compounds,biodiscovery,molecular biology,bioengineering
Quantification of ecological services for sustainable agriculture (QUESSA)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Collaborative project
Countries involved: United Kingdom,Switzerland,Netherlands,Italy,Hungary,France,European organisations area,United Kingdom,France,Estonia,Germany,Hungary
Call:  (FP7-KBBE-2012-6-singlestage, 2012)
Start date: 2013-02-01
End date: 2017-01-31
Duration (months): 48.0
Total project cost (EUR): 3824023.0
EU funding (EUR): 2998006.0
Participants: 14
Project status: CLOSED

The project aims to identify the key semi-natural habitats (SNH), outside and within crops, providing essential ecological services (ES). Vegetation traits will be linked to potential ES provision, case studies will measure actual ES levels and inform models which will show unused opportunities and trade-offs among ES by SNH from habitat to landscape scale. This will be achieved for a range of representative cropping systems and farming intensities in regions dominated by agriculture and matched to the requirements of local and national stakeholders. Surveys will identify key SNH and existing literature will be used to link their vegetation traits to ES provision. ES provision will be measured in existing habitat types (SNH to crop) across economically important cropping systems, farming intensities and four European agro-climatic zones using simple techniques in 16 case studies. A case study is defined by a unique combination of region, crop species, and service. Each case study will concentrate on locally important cropping system and the main ES required. Pollination and pest control have been identified as main ES needed, but also soil fertility, weed control and social services will be considered. The relative socio-economic weight of the studied ecosystem services will be appraised using feedback from national experts using a semi-quantitative method. Data will parameterise spatially explicit models to determine how the vegetation composition, management, shape, area, and placement of SNH in agricultural landscapes affect the distribution of mobile-agent based ecosystem services from farm to landscape level. To investigate synergies and trade-offs in ecological services, multi-criteria analysis will be developed to combine a suite of modules in an integrative modelling framework. Outputs are designed to inform local, national and EU stakeholders on how to improve ES provision from SNH and will include a novel web-based tool.

Keywords: functional biodiversity,biocontrol,pollination,socio-economics,modelling,policy,landscapes