Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Chiral Triamino Iminophosphorane Organocatalysts and their Reactions (CHIRALTIPOCAT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-05-03
End date: 2012-05-02
Duration (months): 24.0
Total project cost (EUR): 172740.8
EU funding (EUR): 172740.8
Participants: 1
Project status: CLOSED

We wish to develop new families of chiral single enantiomer triamino iminophosphorane bases and exploit their high basicity in a series of new organocatalytic asymmetric methodologies for providing ready access to desirable chiral products with high enantio- and diastereocontrol from readily available starting materials. This would constitute a new, powerful and broadly applicable organocatalytic asymmetric strategy to such target molecules. The development of new readily accessible and modular designs for tunable single enantiomer triamino iminophosphorane bases will be carried out via two complementary routes that could allow the synthesis of focused libraries of tens of catalysts for screening in a range of important synthetic transformations. In the first, stereochemically pure azides are heated with phosphorous triamides, which upon release of nitrogen yields the target base in just one simple transformation. As azides can be readily prepared from parent enantiopure alcohols via Mitsunobu inversion or from amines through diazo transfer, the route benefits from a broad-based simple design which can allow much structural variation to the target triamino iminophosphorane bases. An alternate route would employ commercially available or readily prepared chiral ethylene diamines reacting with PCl5 followed by triple N-alkylation. The performance of these new highly basic chiral organocatalysts will then be assessed in a range of addition reactions of methylene and methine pronucleophiles to a range of low reactivity electrophiles. Furthermore, through molecular modelling we would like to elucidate the mechanistic pathway and origins of stereocontrol and finally apply the chemistry in the total asymmetric synthesis of the natural product (R,R)-elacomine. The work will therefore be multidisciplinary, involving the development of innovative catalytic asymmetric organic methods, computational chemistry and target synthesis.

Keywords: physical sciences,organic chemistry,enantioselective organocatalysis,chiral triamino iminophosphorane bases,addition reactions,molecular modeling studies,bioactive natural products
Evaluation of Beneficial Role of Protein Phosphatases and KLF2 in Diabetic Endothelial and Progenitor Cell Repair (EPCREPAIR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-07-01
End date: 2012-06-30
Duration (months): 24.0
Total project cost (EUR): 161748.8
EU funding (EUR): 161748.8
Participants: 2
Project status: CLOSED

Type 2 diabetes has become one of the major causes of cardiovascular risk factor-induced mortality in recent years. The severe endothelial dysfunction associated with diabetes leads to both macrovascular and microvascular disorders culminating in atherosclerosis and foot ulcers. The specific molecular mechanisms underlying this impaired neovascularization are incompletely understood. One of the main hypothesis is an altered function of progenitor cells derived from the bone marrow in diabetes, associated with a decreased number and a dysfunction of proangiogenic mononuclear/endothelial progenitor cells (EPC). We propose that the easily obtained EPC from patients reflect the more general endothelial dysfunction of the adult vasculature. Previous work from our groups has shown beneficial effects of shear stress and KLF2 (Krüppel-like factor 2) on endothelial function and normalization of MAPK networks as well as the specific role of phosphatases like PTP1B in diabetes. The aim of our project will focus on studying activation pathways involving deregulated phosphorylation cascades. Especially the infrequently studied phosphatases known to take part in diabetic pathology will be monitored in EPC isolated from diabetic and healthy subjects. Next, altered MAPKinase and phosphates relays will be studied in in vitro culture modulated by small molecule inhibitors or lentiviral genetic modulation. Specifically, the beneficial role of shear stress and its linked transcription factor KLF2 on EPC function will be assessed. Finally, we will evaluate the therapeutic capacity of identified inhibitors of specific kinases and phosphatases as well as KLF2 after a genetic or physiological (shear stress) overexpression to normalize EPC/endothelial function in a mouse model of revascularization after hindlimb ischemia. This study will thus contribute to the development of pharmaceutical targets and tools necessary for preventing clinical cardiovascular complications of diabetes.

Keywords: cardiovascular biology,diabetes,endothelial progenitor cells,phosphatases,map kinases,revascularization,molecular biology,mice
Dissecting synaptotagmin isoform function: from vesicle docking to fusion pore formation. (EXOSYTS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-01-01
End date: 2013-05-12
Duration (months): 24.0
Total project cost (EUR): 206629.0
EU funding (EUR): 206629.0
Participants: 1
Project status: CLOSED

Exocytosis is at the base of fundamental physiological processes such as neurotransmission and hormone release and elucidating its molecular mechanisms is a major step towards deciphering the immense complexity of brain function. It is well established that synaptotagmins (syts) are essential components of the release machinery that couple the entry of Ca2+ to the fusion of vesicles and subsequent release of their contents. However, many aspects of syt function, and of the interplay between different syt isoforms, in triggering the release process are as yet unknown. In the present project I propose to investigate the roles of different syt isoforms on exocytosis in chromaffin cells and hippocampal neurons. Since both syt-1 and syt-7 cooperatively participate in exocytosis I will first study the modulation of fusion pore properties by these isoforms. This will be done by studying fusion pore formation through single-spike amperometry in chromaffin cells obtained from syt-1, syt-7 and syt-1/syt-7 knockout mice. I will also virally re-express wild type syts and chimeras between both proteins to identify the domains involved in slow and fast secretion. Additionally, I expect to clarify whether vesicles containing syt-1 and syt-7 are recruited during separate phases of release (fast vs. slow) using constructs that express these isoforms tagged with a pH-sensitive YFP. Finally, I will seek to identify a possible function of syt-7 in hippocampal neurons by first studying its subcellular distribution in vesicles vs plasma membrane. Additionally, I will study whether syt-7 plays a differential role in release between GABAergic and glutamatergic neurons. My proposed multidisciplinary approach offers great potential to tackle these questions and is expected to yield original results that may help in deciphering the precise role of different syt isoforms in exocytosis. This will contribute, on the longer term, to our understanding of neuronal communication.

Keywords: neurophysiology,neurochemistry,health sciences
Effect of sublethal thermal injury on the survival and re-growth of Salmonella enteritidis. Model development and application to eggs products (LAGSAL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-07-01
End date: 2012-06-30
Duration (months): 24.0
Total project cost (EUR): 180603.2
EU funding (EUR): 180603.2
Participants: 1
Project status: CLOSED

The European Food Safety Authority and the European Centre for Disease Prevention and Control have published their Community Summary Report on Food-borne Outbreaks in the EU in 2007 and it shows that Salmonella remained the most common cause of food-borne outbreaks. In particular Salmonella enteritidis in eggs has been identified as a major cause of outbreaks. It has been recommended that eggs used in raw or minimally processed foods should be “commercially treated”, usually meaning inactivation by heat treatment. The treatment severity has to be low, in order to minimise the damage to the functional properties of the egg. Whilst the enforcement of this recommendation has helped to reduce the number of cases of Salmonella infections, the kinetics of the recovery and possible growth of Salmonella after heat treatments has not yet been quantified satisfactorily. A well-established and verified mathematical model would be especially important in cases where the heat treatment fails or where the food is cross-contaminated. The predictions generated by the model could be integrated into microbiological risk assessments. The project output would also help to improve the general understanding of the recovery process of bacteria injured by heat treatments.The purpose of this project is to model the survival and re-growth of Salmonella enteritidis after mild heat treatments. A mathematical model will be developed based on experiments in broth. It will be adapted to egg products, while bearing in mind that the medium has a significant influence on the recovery of injured cells, for which not all factors are known. The modelling will take into account: the probability of growth in the recovery medium which will depend on the treatment and environmental conditions; both the effect of the severity of the heat treatment and the environmental conditions on the distribution of the single cell lag times;the effect of the environmental conditions on the growth rate.

Keywords: microbiological risk assessments,mathematical models,bacteriology,food technology,food contamination,food preservation,food safety
Worldscience: Scientific Experts in Trans-European Networks (1770-1840) (WORLDSCIENCE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-06-01
End date: 2012-05-31
Duration (months): 24.0
Total project cost (EUR): 162769.0
EU funding (EUR): 162769.0
Participants: 1
Project status: CLOSED

This project focuses on a limited number of highly mobile polyvalent savants -civilians or military- who were invited by the ruling elites of a foreign country to promote scientific-technological policies. The researcher will study the role of these men of science in multidirectional cultural transfer from a comparative perspective. A uniting factor which makes the comparison feasible is achieved through a selection of independent countries where the ruling elites interiorized the notion of decline, “delay” or backwardness and aimed to overcome it by searching inspiration abroad (Spain, Latin American republics, the Ottoman Empire, Russia). The time span includes the period of Enlightenment and the first decades of constitutional regimes. Biographic method and network analysis will be combined with the analysis of discourse in order to examine the representation and self-representation of these savants whose “cosmopolitan” life trajectories -paradoxically?- often combined with their contribution to the building of modern Nation-States. One of the objectives is to examine whether these men constituted not only networks that crossed the borders, but also a universal imagined community. The researcher also aims to analyze the possibilities and limits of cultural transfer, examining the compatibility and incompatibility of practices, standards and values, as well as the appropriation and hybridization of concepts, focusing on broader political and social framework. The multidirectionality of transfer will be stressed, pointing to Extra-European contribution to the Enlightenment. The project will help the researcher acquire new skills: she will use innovative interdisciplinary methodology and develop intercultural communication skills through the collaboration with an international project on Global and World History led by the host institution. Working in the host institution represents a fundamental step for her in order to achieve an independent leading position.

Keywords: humanities,social sciences,history,savants,transnational,networks,science,technology,transfer,state-building,latin america,the ottoman empire,representation,community,discourse analysis
The role of nuclear pore and inner nuclear envelope proteins in the regulation of recombination and repair pathways in budding yeast (NE AS A HEALING HUB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2010-07-01
End date: 2012-06-30
Duration (months): 24.0
Total project cost (EUR): 174065.2
EU funding (EUR): 174065.2
Participants: 1
Project status: CLOSED

DNA double strand breaks (DSBs) and telomeres both represent ends of a linear chromosome, and both can lead to dangerous genomic rearrangements. Recent studies in budding yeast suggest that persistent DSBs associate with factors in two perinuclear compartments, at nuclear pores and in the inner nuclear membrane (INM). The stability of short telomeres also involves telomere binding to an INM protein, Mps3, and unequal sister chromatid exchange in the rDNA array is prevented by binding another INM protein, Heh1. In the absence of this anchor, rDNA rings are excised leading to premature senescence. From these studies it is clear that the interaction of chromatin with the nuclear periphery contributes to genome stability, yet many questions remain concerning the relocalization and its functional consequences. Are these interactions part of a common mechanism to stabilize or process breaks? Do they cross-talk with each other or do the anchorage sites provide distinct activities specific to the context of the DSB? This proposal will examine the role of nuclear pore and INM proteins in telomere maintenance, rDNA stability and DSB repair, but comparing the outcome of damage at the three sites in various mutant strains. I will use high resolution fluorescence imaging to observe the movement of a randomly distributed DSB to the INM or to pores, which can be distinguished by use of fluorescent tagging and a nup133 mutation. I will determine which repair pathways are regulated by the pores and by INM factors involved in perinuclear anchoring, and finally will investigate whether common mechanisms regulate DSBs processing and the repression of recombination at telomeres or within the rDNA. Intruiguingly all of the nuclear envelope components implicated in this process have homologues in higher eukaryotic cells, which suggests that these mechanisms may be conserved.

Keywords: dna recombination,nuclear pore,inner nuclear envelope,rdna stability,live imaging,telomere maintenance
Sociological identification of the actors, practices, discourses and technologies involved in the conservation of media-art works (SOMEART)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2010-07-01
End date: 2013-06-30
Duration (months): 36.0
Total project cost (EUR): 239551.0
EU funding (EUR): 239551.0
Participants: 1
Project status: CLOSED

The increasing engagement of artists with film, video, computers and the internet, has enabled the emergence of an unprecedented variety of ‘media-art’ forms, such as video-art, audio-visual installations, multimedia art, digital-art or net-art. However, the dependence of these media-art works on rapidly evolving technologies makes these works one of the most fragile parts of our contemporary artistic heritage. This research proposes a pioneering sociological investigation on media-art conservation practices. Its main objective is to identify the networks of technologies, practices, discourses and actors involved in the preservation of media-art works These objectives will be met by undertaking advanced training at New York University’s Sociology Department (USA) and by conducting an ethnographic study of media-art conservation practices at the Museum of Modern Art of New York (MoMA). This investigation will be transferred to the Centre for Research on Socio-Cultural Change (CRESC) at The Open University (UK), where it will contribute to establish a new line of research on the material dimensions of culture. The results of the study will be of great significance for both museum professionals in charge of the conservation of media-art collections and for cultural sociologists dealing with the processes of cultural preservation. This project will be instrumental to forge an international and interdisciplinary research network of academics, museum and cultural-policy professionals working on the intellectual and policy-related challenges facing contemporary art conservation and, more widely, culture in a digital age.

Keywords: cultural sociology,media-art,conservation,ethnography,museums,digital culture,material cultures
Genetics of Systemic lupus erythematosus in northern and southern European populations (GENETICS OF SLE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-09-06
End date: 2013-09-05
Duration (months): 24.0
Total project cost (EUR): 173240.8
EU funding (EUR): 173240.8
Participants: 1
Project status: CLOSED

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease mediated by autoantibodies, which recognize nuclear and tissue specific antigens.The aetiology of this disease is incompletely determined. However, the risk to SLE has a significant genetic component, a conclusion supported by successful genome wide association studies (GWAS) in SLE published since 2008 - all were conducted in US-based cohorts. The variability within the “top hits” generated by each GWAS indicates the lack of power of these studies. In order to confidently define the full genetic architecture of SLE a significantly larger study will be required. My host laboratory is leading the effort in a well-powered GWA experiment in 5,500 SLE cases, collected from Northern and Southern Europe. First, high density SNP genotyping will be performed using Illumina Omni-Quad chip. I will participate in the ensuing genetic associations analyses on the data generated. Thereafter, I will make a meta-analysis of these GWAS data with the published GWAS in SLE in northern European populations and then to compare these data with the data of the southern European GWAS. We will seek replication for novel associations in additional samples available through the SLEGEN consortium. Finally I will select one novel locus in which to conduct functional studies that will help to clarify the role of the locus in SLE ethiopathogenesis.

Keywords: healht sciences,population genetics,systemic lupus erythematosus,genetics,genome-wide association study,fine mapping,bioinformatics
Cultural Approach of Radical Islamism in the Context of European Pluralism: Radical versus Moderate Muslims. (CARP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-11-01
End date: 2012-10-31
Duration (months): 24.0
Total project cost (EUR): 230927.2
EU funding (EUR): 230927.2
Participants: 1
Project status: CLOSED

The radical Islamism is often presented in the political debate through the prism of religion or geopolitics. Following March 11, 2004 Madrid attacks the European commission has, for the first time, assumed this phenomenon to be the expression of the problem of radicalisation. Moreover, this phenomenon is analysed in the global strategic debate without taking into account the anthropological knowledge of the radicalisation at the local and national levels. Our project consists in filling this gap by leading an empirical, innovative and independent study of the cultural process of Islamist radicalisation in Europe. The Islamist radicalization is presented in the numerous studies in social sciences as the revival or the continuity of the ancient Islamic tradition or of the classical Islamic religious. We intend to confront in the empirical way the cultural tradition and the Islamism. The radicalisation expresses itself by excluding the other, including the non radical Muslims. For us, this phenomenon arises the political question of alterity and ethnicity. Iterdisciplinary our research project arises in the field the question of the emergence, in the democratic political contexts, of the new political forms of dissidence in cases of Moderates and Radicals Muslims in Spain, France and United-Kingdom.

Keywords: political islam,radicalisations,ethnicity,muslims,immigrants,pluralism,democracy,diversity,ethnographic,fieldwork