Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Modular, scalable and high-performance DE-polymerization by MicrowavE TechnolOgy (DEMETO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Germany,Spain,Italy,Italy,Germany,Italy,Switzerland,Switzerland,Lithuania,Sweden,Belgium,Denmark,United Kingdom
Call: Pilot lines based on more flexible and down-scaled high performance processing (H2020-SPIRE-2017, 2017)
Start date: 2017-09-01
End date: 2021-09-30
Duration (months): 49.0
Total project cost (EUR): 9890857.14
EU funding (EUR): 7808937.5
Participants: 16
Project status: CLOSED

Based on an internationally patented technology, the project foresees to bring at industrial level (through a completely functional pilot plant) the usage of microwaves as Process Intensification approach (through an electromagnetic catalytical effect) of the well-known alkaline hydrolysis depolymerization reaction. Such reaction was, up to know, economically unfeasible due to a certain number of technological constraints that DEMETO finally solves. Coordinated by PROCESSI INNOVATIVI, R&D company of a large EPC (Engineering, Procurement and Construction) group, but supported by a large basis of SMEs that will bring the most innovative aspects of the project technology, DEMETO's Consortium is composed by highly skilled members, which can guarantee the appropriate exploitation of the project business case, also thanks to the involvement of all the major commercial stakeholders of the PET value chain, including the most relevant Customer Segments. In fact, having followed all previous steps from lab-level testing (TRL3) to industrial demonstration of the core reactor (TRL6), we are now in the position to further move the technology towards its market deployment, by building a pilot plant (containing a full reactive unit) that would act as industrial demonstration of the performances of DEMETO's de-polymerization approach to the market. One of the project major strengths is in fact that the market is ready to accept DEMETO's technology. The existing value chain of post-consumer recovery of PET plastic waste is perfectly apt to accept the introduction of a new "ring of the chain", that would close the loop into a circular economy model, acting either at the end of the chain (mechanical recyclers) or at its beginning (PET producers). This gives us a total addressable market of about 60 plants in Europe (270 worldwide), for a value of around €1.2bn (€5.4bn worldwide).

Keywords: depolymerization,recycling,circular economy,microwaves,plastics,polyester,waste2resource
Dynamic Control of Mineralisation (DYNAMIN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-09-01
End date: 2025-08-31
Duration (months): 84.0
Total project cost (EUR): 2632375.0
EU funding (EUR): 2632375.0
Participants: 1
Project status: SIGNED

This project will take inspiration from biomineralisation to achieve exceptional, dynamic control over crystallisation processes. Understanding the fundamental mechanisms which govern crystallisation promises the ability to inhibit or promote crystallisation as desired, and to tailor the properties of crystalline materials towards a huge range of applications. Biomineralisation provides a perfect precedent for this approach, where organisms achieve control currently unparalleled in synthetic systems. This is achieved because mineralisation occurs within controlled environments in which an organism can interact with the nascent mineral. Thanks to recent advances in microfabrication techniques and analytical methods we finally have the tools required to bring such control to the laboratory. DYNAMIN will exploit microfluidic and confined systems to study and interact with crystallisation processes with outstanding spatial and temporal resolution. Flowing droplet devices will be coupled to synchrotron techniques to investigate and control nucleation, using soluble additives and nucleating particles to direct the crystallisation pathway. Static chambers will be used to interact with crystallisation processes over longer length and time scales to achieve spatio-temporal control to rival that in biomineralisation, while a unique confined system – titania nanotubes – will enable the study and control of organic-mediated mineralisation, using fresh reagents and proteinases to interact with the process. Finally, a key biogenic strategy will provide the inspiration to develop a simple and potentially general method to trigger and control the transformation of amorphous precursor phases to single crystal products. This will generate a new framework for studying and controlling crystallisation processes, where these new skills will find applications in sectors ranging from the Chemical Industry, to Healthcare, Advanced Materials, Formulated Products and the Environment.

Keywords: crystallization,biomineralization,calcium carbonate,bio inspired,microfluidic
Vessel co-option and radioresistance in glioblastoma (VESSEL CO-COPTION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: France
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-08-01
End date: 2024-07-31
Duration (months): 60.0
Total project cost (EUR): 1499823.0
EU funding (EUR): 1499823.0
Participants: 2
Project status: SIGNED

Glioblastoma (GBM) is one of the deadliest types of human cancer. Despite a very aggressive treatment regime – including resection of the tumor, radiation and chemotherapy – its estimated recurrence rate is more than 90%. Recurrence is mostly caused by the regrowth of highly invasive cells spreading from the tumor bulk, which are not removed by resection. To develop an effective therapeutic approach, we need to better understand the underlying molecular mechanism of radiation resistance and tumor spreading in GBM. Radioresistance in GBM is attributed to glioma stem cells (GSCs), a fraction of perivascular, self-renewing, multipotent and tumor-initiating cells. Growing evidence highlights the perivascular space as a niche for GSC survival, resistance to therapy, progression and dissemination. The unknown factor is the dynamics of GSCs, how they end up in the vascular niche and how this impacts on radioresistance. My overall hypothesis is that GSCs reach the perivascular niche through vessel co-option - the directional migration of tumor cells towards vessels - and that targeting vessel co-option has the potential to radiosensitize GBM. With this project, we aim to uncover the exact molecular and cellular connections among vessel co-option, GSCs, the vascular niche and radioresistance. Using multiple strategies, such as multiphoton intravital microscopy, orthotopic models of GBM, organotypic cultures, screenings and survival studies, we will investigate and mechanistically change the dynamics of GSC and differentiated GBM cells in order to understand the role of their interaction with brain vessels and whether this confers resistance to radiotherapy. These studies will provide clinically relevant insights into the involvement of GSCs, the vascular niche and vessel co-option in the resistance of GBM to therapy. Since all GBM patients receive radiotherapy, many would benefit from therapeutic strategies aimed at increasing its efficacy.
Fine-tuning the brain’s brakes – modulating inhibitory control with transcranial alternating current stimulation (TUNING-BRAKES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-03-01
End date: 2022-10-23
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Inhibitory control over unwanted thoughts, emotions and movements is essential for effective interaction with our environment. This becomes particularly evident when there is too little inhibition, as in obsessive-compulsive disorder or Tourette’s syndrome, or too much, as in Parkinson’s disease. Recent evidence links successful inhibition to the power of neural oscillations in the beta band (15-30Hz) in a circuit involving the frontal cortex and the subthalamic nucleus. While this is an important step forward, it is not yet sufficient to develop effective neuromodulatory treatments for inhibitory control disorders. For that, we need to understand how the beta oscillations mediate neuronal communication within the fronto-subthalamic circuit. In this proposal, I address this challenging question through novel applications of transcranial alternating current stimulation (tACS). This non-invasive brain stimulation technique aligns neuronal oscillations to an oscillating low-intensity electrical current applied to the brain. This external control over oscillatory power and phase will allow me to investigate: (1) the functional relevance of beta oscillatory phase, and (2) the causal role of interactions between beta oscillations and other frequency bands (‘cross-frequency coupling’). Subsequently, I will develop an innovative, non-invasive, treatment strategy for inhibitory control deficits, by recording and modulating abnormal circuit activity only when present. Maastricht University is the ideal place to perform this research program as it is one of the only institutes in the world that has access to a new generation of deep brain stimulators, enabling concurrent recording of cortical and subthalamic activity, and it houses one of the pioneering groups in using oscillation-based non-invasive brain stimulation. Integration within this multidisciplinary team will offer an exceptional opportunity to increase my skill set, and capability to launch my own research group.

Keywords: beta oscillations,transcranial alternating current stimulation,cross frequency coupling,inhibitory control,parkinson s disease
Identification and characterization of the sex pheromone sensitive response gene(s) in the European Corn Borer males (ECBStrainShift)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-15
End date: 2017-10-14
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Night-active Lepidoptera are among the most speciose group of animals (~120.000 known species) and they possess a unique sexual communication system: females attract conspecific males by using a species-specific sex pheromone blend. Due to this fine-tuning, the development of novel pheromone systems is an evolutionary mystery: production of a new pheromone blend by females and preference for that blend by males must be established simultaneously, which is difficult to explain when the female blend and the male response are controlled by independently assorting genes. The pheromone strains of the European Corn Borer, Ostrinia nubilalis provide one of the best model system for a better understanding of pheromone (co)-evolution, because in these strains the females produce opposite proportions of E11- and Z11-tetradecenyl acetate, to which only strain-specific males are attracted. The genes responsible for the strain difference in female production are autosomally encoded and identified as fatty-acyl reductase while the gene(s) underlying male response has(have) been found to be sex-linked but have not been identified yet. For years they have been hypothesized to be olfactory receptors (ORs). However, we found with fine-scale mapping that the ORs map away from the Z-linked response locus and we showed two new candidate genes mapping at the male response region on the Z chromosome. The new candidates are involved in neurogenesis in other species and therefore are interesting for all olfaction and neurogenesis studies, including studies on humans. With our multidisciplinary experience, combining genetic engineering, neurophysiology and behaviour, we wish to identify the genetic change of the genes underlying male response in O. nubilalis and functionally characterize their involvement in olfaction. This approach has the potential to a) identify novel genetic mechanisms that underlie the evolution of pheromone communication and b) develop new pest management strategies

Keywords: olfaction,ostrinia nubilalis,insects,pheromones,sexual chromosome,olfactory receptors,developmental genes,electrophysiology
Social and innovative Platform On cultural Tourism and its potential towards deepening Europeanisation (SPOT)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Reflective societies - cultural heritage and European identity
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Estonia,Italy,Israel,Germany,Greece,Hungary,Poland,Romania,Slovakia,Slovenia,Czechia,Netherlands,United Kingdom
Call: Innovative approaches to urban and regional development through cultural tourism (H2020-SC6-TRANSFORMATIONS-2019, 2019)
Start date: 2020-01-01
End date: 2022-12-31
Duration (months): 36.0
Total project cost (EUR): 3000000.0
EU funding (EUR): 3000000.0
Participants: 15
Project status: CLOSED

Cultural tourism is changing. The traditional forms still exist – museums, art galleries, landscapes, historical sites, festivals – but both cultural destinations and the tourists are under transformation. Many ‘cultural tourists’ see themselves neither as seeking culture nor as tourists; there is increasing evidence of people seeking to experience culture rather than merely observing it. That is: agri-tourism where visitors want to experience rural life; people wanting to visit the actual venues of TV crime thrillers; culture being explored by those using themed routes in winery regions or via pilgrimage. These trends provide opportunities to both revitalise poorer and rural areas through economic and social development while protecting local cultures and landscapes. The project brings an extension of existing policies and the promotion of new approaches. The project’s aim is to develop a new approach to understanding and addressing cultural tourism and to promote development of disadvantaged areas. Based on an Innovation Tool and digital technology the project identifies layers of data and capitalise on existing practice, explores emerging forms of cultural tourism, identifies opportunities and develop strategies allowing local people to gain local benefit from their precious cultural assets. The project uses case studies across 15 European regions, consolidates definitions of ‘cultural tourism’, engages academics and stakeholders in developing policy proposals in practice and posits means of generalising the lessons via an Innovation Tool to assist policy-makers at all levels as well as practitioners. Positive and negative aspects of cultural tourism exist; a balanced development path needs to be sought. The project will help to identify themes and areas where intervention at local, regional, national and European levels may assist in achieving successful developments, it will help in managing that balance and offering solutions.

Keywords: cultural tourism,new innovation tool,urban and regional development,european cultural heritage,rural landscape,good practice,case studies
Production, Trade and Governance: a New Framework for the Understanding of Organized Crime (CRIMGOV)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: France,United Kingdom
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-11-01
End date: 2026-10-31
Duration (months): 60.0
Total project cost (EUR): 2492911.0
EU funding (EUR): 731600.0
Participants: 2
Project status: SIGNED

There is a consensus that organized crime (OC) is harmful and its profits are immense. Yet the concept of OC itself lumps together people engaging in very different activities—from peasants in Colombia to professional enablers in London to mafias in Italy—, and the data used by scholars are generally of poor quality. We are in urgent need to establish this field of study on solid analytical grounds and to produce good data. CRIMGOV is designed to do precisely that. We first present a framework that distinguishes three key activities of OC groups: Production, Trade and Governance. We will ask: How do groups engaged in (criminal) Production, Trade or Governance differ from each other? Do they each have a different organizational structure, members with different ‘professional’ profile and skills? To what extent is there overlap between them? Finally, under which conditions would one group specializing in Production or Trade evolve into a Governance-type OC group? The project will study a broad range of organized crime in depth: local cybercrime production hubs in Europe, the international trade of drugs from Colombia to Europe, the emergence of criminal governance inside and outside prisons. The project will produce high-quality data sets that are hard to collect and time-consuming to code, a challenging and risky yet highly rewarding contribution to knowledge. Breaking traditional disciplinary boundaries between the social sciences and adopting a global outlook, CRIMGOV will overturn long-held theoretical approaches, produce substantial new findings and data, and speak to scholars across different disciplines.

Keywords: organized crime,governance,drugs trafficking,prisons
Gender-Gap in Political Endurance: a novel political inclusion theory (SUCCESS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Norway
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2335750.0
EU funding (EUR): 2335750.0
Participants: 1
Project status: SIGNED

Democracies are under pressure worldwide: The political landscape is rapidly changing, with new parties emerging and old ones suffering, as voters turn away from established parties. We also witness a significant gender-gap in political endurance, meaning that women’s careers as elected representatives in parliaments tend to end quicker than men’s. SUCCESS argues that questions of women’s political endurance are of uttermost importance for the quality and legitimacy of democratic processes and therefore demand scholarly attention. SUCCESS will advance a novel theory of inclusion that explains gender-gaps in endurance, and provide much-needed new empirical evidence on why, how and under what conditions women’s political careers are likely to endure. SUCCESS will investigate the multifaceted relationships between a) the agency of elected representatives, i.e. their choice of strategies to get re-elected b) popular opinions about representatives’ gender, political experience and their career strategy, and c) the specific institutions and contexts that underpin gender-gaps in political endurance across time, regions and political systems. SUCCESS thus offers a comprehensive perspective, highlighting the interconnections between these three aspects in a novel theory of political inclusion: Rather than focusing on what excludes women from political office, the project explores what contributes to their success. SUCCESS will employ a unique multi-methods approach to collect data in five core country cases and a large-N dataset, including qualitative interviews, survey experiments, conjoint analysis, simulation study and anthropological film. These efforts yield unprecedented opportunities for a new turn towards understanding how gender-gaps in political endurance affect political inequalities. The project is pioneering empirical studies on why and how increased electoral volatility in new and old democracies disrupts or reinforces gendered power hierarchies in politics.

Keywords: gender equality,political representation,parliaments,elections