Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A cost effective and efficient approach for a new generation of solar dish-Stirling plants based on storage and hybridization (BIOSTIRLING-4SKA)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable electricity generation
Action type: Collaborative project
Countries involved: Sweden,Finland,Spain,Spain,Spain,Netherlands,Portugal,Germany,Finland,Spain,Portugal,Germany
Call:  (FP7-ENERGY-2012-1-2STAGE, 2012)
Start date: 2013-06-01
End date: 2017-04-30
Duration (months): 47.0
Total project cost (EUR): 5258418.97
EU funding (EUR): 3433106.37
Participants: 15
Project status: CLOSED

In the context of the Energy SET-Plan of the European Commission relevant research and developments channelled to increase the percentage of renewable energy sources. It is crucial the collaboration of the Industry, SME’s and research institutions to bring together the step forward to finally integrate renewable energies as the main source of electricity. Renewable energies represent a wide field upon which international research needs to be focused. The necessity has been envisaged by the BIOSTIRLING consortium and it has been supported by the synergies found with the large-scale international project SKA. The SKA antennas and reception centres, constitute a continental scale sensor network. Aligned with the trend of renewable resources, the overall objective of the project is to implement a cost effective and efficient new generation of solar dish-Stirling plant based on hybridization and efficient storage at the industrial scale. In order to achieve successfully the ambitious objective, the collaboration performed by the consortium will take the advantage of the expertise of the members in the developing of a Solar Dish/Stirling system, which besides being more operative in terms of construction, transportation and commissioning, it will be more efficient than actual systems because an innovative storage device and a bio-hybrid energy collector will be developed to guarantee the electricity supply independently on time and weather conditions. Increased modularity of the system will enable the Solar Dish/Stirling system to act as an energy supplier not only to the grid but also in specific uses as supplying energy to the SKA project, which sets the most challenging power requirements of any Large Research Facility.

Keywords: solar dish system,solar energy,concentrator,stirling engine,hydrogen-based storage,biomass,synthesis gas generation
Innovative Reliable Chip Designs from Low-Powered Unreliable Components (I-RISC)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Future and Emerging Technologies
Action type: Collaborative project
Countries involved: France,France,Netherlands,Romania,Ireland,Serbia
Call:  (FP7-ICT-2011-C, 2011)
Start date: 2013-02-01
End date: 2016-01-31
Duration (months): 36.0
Total project cost (EUR): 2161095.0
EU funding (EUR): 1613284.0
Participants: 6
Project status: CLOSED

The ongoing miniaturization of data processing and storage devices and the imperative of low-energy consumption can only be sustained through low-powered components. Lower supply voltages and variations in technological process of emerging nanoelectronic devices make them inherently unreliable. As a consequence, the nanoscale integration of chips built out of unreliable components has emerged as one of the most critical challenges for the next-generation electronic circuit design. To make such nanoscale integration economically viable, new solutions for efficient and fault-tolerant data processing and storage must now be invented. The i-RISC project aims at achieving these goals, by providing innovative fault-tolerant solutions at both device- and system-level that are fundamentally rooted in mathematical models, algorithms, and techniques of information theory. Proposed solutions will build on error correcting codes and encoder/decoder architectures able to provide reliable error protection even if they themselves operate on unreliable hardware. The project will develop the scientific foundation and provide a first proof-of-concept by validating the proposed solutions on accurate error models and energy measurement tools developed within the project. In the forthcoming challenge of nanoscale technologies, the i-RISC project is an essential prerequisite for preparing the European industry for this paradigm shift.

Keywords: fault tolerance,nanoscale integration,low-powered chip,error correcting codes,fault-tolerant codecs,in-chip coding,reliable storage and transport,reliable synthesis
Exploring the tumor as a communicating organ (TUMORGAN)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physiology, Pathophysiology and Endocrinology
Countries involved: Sweden
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2013-03-01
End date: 2018-02-28
Duration (months): 60.0
Total project cost (EUR): 1498149.6
EU funding (EUR): 1498149.6
Participants: 1
Project status: CLOSED

The failure to bring about major advances in cancer care over the past decades points to the need for a revolution in our view of cancer as a disease caused by a lack of growth control in malignant cells. We propose that a tumor should be considered a communicating organ made of multiple cell types that collectively evolve into a clinically manifested and deadly disease. With this proposition follows that targeting of communication within tumors to attenuate the support from the stroma is the only viable strategy to achieve long term therapeutic benefit. Our research addresses the need to study the cellular context of cancer with a higher resolution. The general aim of the proposed work is to identify subsets of different cell types within the tumor stroma that hold utility as therapeutic targets and biomarkers. The work will be performed through a set of experiments bridging basic biology, pre-clinical studies and molecular oncology. The specific aims are: 1) Identification of cellular subsets of the tumor vasculature 2) Investigation of the therapeutic utility of cellular subsets of the tumor vasculature 3) Exploration of the potential of cellular subsets of the tumor vasculature as biomarkers The aims of the study will be pursued through a series of methodological refinements. Firstly, identification of novel components of tumors will be achieved by the assembly of a mouse genetic tool box enabling isolation, lineage tracing and functional studies. Secondly, single cell transcriptome sequencing will be performed to identify cellular subsets using materials from both mouse and man. Thirdly, the utility as therapeutic targets of the new cellular subsets will be assessed using a live imaging approach. Fourthly, the clinical significance of the new cellular subsets will be investigated using exclusive patient materials. Taken together, the information provided by our studies will enable us to take cancer therapy into a new era of personalized medicine.

Keywords: cancer,tumor microenvironment,angiogenesis,paracrine signaling,cellular subsets,targeted therapy,personalized medicine,translational science,pericyte,endothelial cell
Biological Foundation for the Safety Classification of Engineered Nanomaterials (ENM): Systems Biology Approaches to Understand Interactions of ENM with Living Organisms and the Environment (NANOSOLUTIONS)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Finland,Sweden,Ireland,Netherlands,France,United Kingdom,United Kingdom,United Kingdom,Spain,Germany,Spain,Denmark,Italy,Germany,Switzerland,Germany,Germany,Germany,China,Brazil,South Africa,United States,Belgium,Italy,Belgium,United Kingdom,Spain
Call:  (FP7-NMP-2012-LARGE-6, 2012)
Start date: 2013-04-01
End date: 2017-03-31
Duration (months): 48.0
Total project cost (EUR): 13765733.83
EU funding (EUR): 10000000.0
Participants: 39
Project status: CLOSED

The main objective of this research proposal is to identify and elaborate those characteristics of ENM that determine their biological hazard potential. This potential includes the ability of ENM to induce damage at the cellular, tissue, or organism levels by interacting with cellular structures leading to impairment of key cellular functions. These adverse effects may be mediated by ENM-induced alterations in gene expression and translation, but may involve also epigenetic transformation of genetic functions. We believe that it will be possible to create a set of biomarkers of ENM toxicity that are relevant in assessing and predicting the safety and toxicity of ENM across species. The ENM-organism interaction is complex and depends, not simply on the composition of ENM core, but particularly on its physico-chemical properties. In fact, important physico-chemical properties are largely governed by their surface properties. All of these factors determine the binding of different biomolecules on the surface of the ENM, the formation of a corona around the ENM core. Thus, any positive or negative biological effect of ENM in organisms may be dynamically modulated by the bio-molecule corona associated with or substituted into the ENM surface rather than the ENM on its own. The bio-molecule corona of seemingly identical ENM cores may undergo dynamic changes during their passage through different biological compartments; in other words, their biological effects are governed by this complex surface chemistry. We propose that understanding the fundamental characteristics of ENM underpinning their biological effects will provide a sound foundation with which to classify ENM according to their safety. Therefore, the overarching objective of this research is to provide a means to develop a safety classification of ENM based on an understanding of their interactions with living organisms at the molecular, cellular, and organism levels based on their material characteristics.

Keywords: engineered nanoparticles,material characteristics,protein corona,omics technologies,translocation,systems biology. life cycle assessment,safety classification
Self healing innovative elastomers for dynamic seals, damping and noise reduction (SHINE)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Materials
Action type: Collaborative project
Countries involved: Netherlands,Spain,France,Germany,France,Germany,Spain,Netherlands,Netherlands,Portugal,Netherlands,Switzerland
Call:  (FP7-NMP-2012-SMALL-6, 2012)
Start date: 2013-02-01
End date: 2016-07-31
Duration (months): 42.0
Total project cost (EUR): 6199481.0
EU funding (EUR): 3951749.0
Participants: 12
Project status: CLOSED

Overall objective of the SHINE project is to develop a novel generation of elastomers that undergo spontaneous self-healing, leading to enhanced durability and reliability of the products made thereof (dynamic seals, shock absorbers, anti-vibration devices for vehicles, roads, railroads and bridges). The elastomers can heal without human intervention and can undergo multiple healing stages. They can prevent damage propagation by healing the microcracks or repair themselves in the case of accidental break. The objectives include also developing and standardizing test methods to quantify the efficiency and effectiveness of the self-healing process. The scientific and technical concept is based on the use of dynamic crosslinks both covalent and supramolecular (H-bonds and ionic interactions) that can be broken and reversibly reestablished to provide self-healing. Supported by the SHINE Exploitation Plan the new elastomers will be used to formulate, compound, manufacture and evaluate the final products as listed above. The results will be disseminated to initiate further research in this field. The products made by the self-healing elastomers will have prolonged lifetime, will increase reliability and enhance safety when used in vehicles, machinery and transportation infrastructure. The societal benefits are in reduction of roads incidents, injuries and fatalities, reduction in environmental pollution, and reduction of urban noise. The economic benefits include less road maintenance work, less traffic jams and waste of time associated with this, savings in energy and natural resources consumption, reduced machinery idle time due to frequent reparations, and reduced transportation costs, which will eventually improve the competitiveness of the European industry. A total of 574 person-months with project duration of 42 months are proposed for achieving the objectives of the project. SHINE has a budget of 6,2 million €, with a requested EC funding of 3,9 million €.

Keywords: self healing,elastomers,rubbers,seals,damping,noise reduction,rail roads,bridges,motorways
Self-healing concrete to create durable and sustainable concrete structures (HEALCON)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Materials
Action type: Collaborative project
Countries involved: Belgium,Belgium,Netherlands,Spain,Germany,Germany,Finland,Denmark,Denmark,Spain,Portugal
Call:  (FP7-NMP-2012-SMALL-6, 2012)
Start date: 2013-01-01
End date: 2016-12-31
Duration (months): 48.0
Total project cost (EUR): 5610518.8
EU funding (EUR): 3997429.0
Participants: 13
Project status: CLOSED

Within the call “Self-healing materials for prolonged lifetime”, self-healing concrete is an important topic. Adequate perpetuation of the road, tunnel and bridge network, is crucial to preserving European cohesion and business operations; and around 70% of this infrastructure is made of concrete. In order to guarantee liquid tightness of concrete structures, and enhance durability of elements prone to bending cracks, smart concrete with self-healing properties will be designed. Thanks to the existing expertise of the consortium in the field of self-healing concrete at a lab scale, a thoughtful selection of promising techniques is possible. For early age cracks a non-elastic repair material can be proposed, such as calcium carbonate precipitated by bacteria, or new cement hydrates of which the formation is stimulated by the presence of hydrogels. For moving cracks under dynamic load, an elastic polymeric healing agent is suggested. Different healing agents and encapsulation techniques are tested and scaled up. Self-healing efficiency is evaluated in lab-scale tests using purposefully adapted monitoring techniques, and optimized with the help of suitable computer models. Finally the efficiency is validated in a large scale lab test and implemented in an actual concrete structure. Life-cycle cost analysis will show the impact of the self-healing technologies on economy, society and environment compared to traditional construction methods.

Keywords: self-healing,concrete,bacteria,polymer,hydrogel,super absorbing polymer,cracking,liquid-tightness,durability,sustainability,safety,infrastructure
Grant to develop several composite indicators relevant for the monitoring of the progress towards objectives in the ERA and the Innovation Union (COMPOSITES 4 IU)

Framework: FP7 — Capacities
Programme: Support for the coherent development of research policies
Destination: Support for the coherent development of research policies
Action type: Coordination and support actions
Countries involved: European organisations area
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2012-04-01
End date: 2013-09-30
Duration (months): 18.0
Total project cost (EUR): 560748.0
EU funding (EUR): 499999.0
Participants: 1
Project status: CLOSED

The EU2020 strategy contains a blueprint for transforming Europe into an ‘Innovation Union’ by 2020. The Innovation Union flagship initiative (October 6th, 2010) commits the EU to boosting investment in research and making Europe an attractive place to develop innovative products. According to this initiative, national governments will have to reform their innovation systems to boost cooperation between industry and universities, ensure a modernization of framework conditions for enterprises, and enact additional measures to enhance cross-border cooperation and to embrace joint programming. All these innovation aspects need to be carefully monitored by policy-makers in the European institutions, Member states and Regions. The focus of this project is on monitoring some key structural dimensions of the Innovation Union and the European Research Area (ERA). The study builds on the findings of a feasibility study called ERA_MONITORING carried out by the proponent in 2011 and financed by the 2010 Capacities work programme. The study addresses the development of four sets of indicators regrouped in relevant sub-dimensions and ultimately hinged into composite indicators to measure: 1) progress towards a unified European Research Area (ERA), to attract talent and investment in order to create a genuine single market for knowledge, research and innovation. 2) progress towards higher research excellence, meaning the vitality of the research environment and the quality of research outputs in both basic and applied research; 3) structural change in the economy, to monitor the increase towards a more knowledge-intensive economy in Europe coherently with the orientations of the EU 2020 strategy and the Innovation Union initiative; 4) diffusion of knowledge and technology between research institutions and industry to monitor the increase of knowledge transfer practices in view of optimizing market and societal uptake.

Keywords: indicators,era,structural change,research excellence,knowledge and technology diffusion
small RNA mediated heterochromatin formation in fission yeast (SMALLRNAHET)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Genetics,Genomics,Bioinformatics and Systems Biology
Countries involved: Germany
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2012-11-01
End date: 2018-10-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Regulation of genome expression is essential for cell proliferation, differentiation, development and viability. Small RNA silencing pathways are involved in the cellular control of gene expression and in protection of the genome against mobile repetitive DNA sequences, retroelements and transposons. Small RNAs interact with target RNAs and promote chromatin modifications, translational inhibition or degradation of complementary RNAs. We have uncovered new class of small RNAs in fission yeast, priRNAs, which are generated independently of Dicer. priRNAs are likely to be involved in triggering of siRNA amplification and heterochromatin assembly within centromeric repeats. In first aim, using small RNA sequencing and transcriptomic approaches, combined with biochemistry and functional assays, we will determine biogenesis and function of noncentromeric priRNAs. Specifically, Argonaute-dependent 3' end formation of priRNAs will be studied, a process conserved in piRNA biogenesis in higher eukaryotes. In second aim, we will study what recruits RNAi to transposable and repetitive elements. Furthermore, we will study RNA susceptibility to RNA interference. In third aim, we will use cryo electron microscopy to determine structure of chromodomain protein Chp1 bound to nucleosomes with histone 3 lysine 9 methylated. We will extend this study on other RNAi and heterochromatin complexes. Defects in small RNA-mediated regulation of genome expression have been described in several human cancers. Fundamental understanding of the role of small RNAs in gene regulation will help us understand why some cells loose their identity and turn into cancer cells.

Keywords: rnai mediated heterochromatin formation,small rna biogenesis,cryo em of chromatin complexes
Multi-Dimensional Lab-On-Chip (MUDLOC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Applied life sciences and biotechnology
Countries involved: Israel
Call:  (ERC-2012-StG_20111109, 2012)
Start date: 2013-02-01
End date: 2018-01-31
Duration (months): 60.0
Total project cost (EUR): 1497990.0
EU funding (EUR): 1497990.0
Participants: 1
Project status: CLOSED

There are several bottlenecks that hinder certain aspects of proteomics, in particular, incompatibility of high throughput technologies with certain protein types or modifications, low sensitivity and lack of quantitative data. I have developed a microfluidics affinity assay compatible with transmembrane proteins and post-translational modifications that is highly sensitive and can provide quantitative data. The primary objective of this proposal is to bioengineer, using the abovementioned building blocks, a multi-functional microfluidic-based human protein arrays. The platform will enable addressing important scientific questions not otherwise possible. Specifically, the process of DNA demethylation, which is poorly characterised due to technological limitations. The biological aspects of chromatin methylation and their regulators that are crucial for cell differentiation and disease will be studied. Work in MuDLOC will include the following: i) Bioengineering of a microfluidic-based platform that expresses thousands of human genes; ii) Design new tools for post-translational modifications and chromatin modifications; iii) Search for chromatin modifiers and their regulators; and iv) Exploration of specific inhibitors using a microfluidic inhibitor screen. Beyond studying chromatin methylation from a new perspective, MuDLOC will greatly benefit a plethora of disciplines, such as proteomics, genomics and cancer research. At the end of the project my vision is to capture under one platform a whole pathway, including protein interactions, post-translational modifications and chromatin modifications.

Keywords: integrated microfluidics,protein arrays