Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Chromosomal Condensin Dynamics: From Local Loading to Global Architecture (CHROCODYLE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2023-05-31
Duration (months): 72.0
Total project cost (EUR): 1999599.0
EU funding (EUR): 1999599.0
Participants: 1
Project status: SIGNED

Striking morphological transformations are a hallmark of any cell division cycle. During nuclear division chromatin is compacted into distinctive rod-shaped chromatids in preparation of chromosome segregation by the spindle apparatus. Multi-subunit SMC protein complexes and a large number of regulatory factors are at the heart of this elementary process. SMC complexes also play key roles during other aspects of genome function such as the control of gene expression and the repair of damaged DNA. They are thought to act as chromatin linkers with exquisite specificity for certain pairs of DNA fibres. However, the underlying molecular mechanisms are not understood. Active extrusion of DNA loops by the SMC complex has been proposed to be the mechanistic basis for the establishment of long-range, intra-chromatid DNA bridges. Here, I put forward a multi-pronged research programme that aims to elucidate fundamentally conserved features of SMC protein function and action using the prokaryotic SMC condensin complex in Bacillus subtilis as a tractable model system. We will conduct a combined structural, biochemical and cell biology approach (including crystallography, electron paramagnetic resonance, ChIP-Seq and ‘native’ HiC) to uncover how the SMC complex acts at the higher levels of organization of the bacterial chromosome to promote the efficient individualization of sister DNA molecules. We will reveal the molecular and structural bases for the association between the SMC complex and the bacterial chromosome at different stages of the loading reaction – each representing a crucial intermediate in a sophisticated chromosome organization process. For the first time, we will be able to map the paths of chromosomal DNA through an SMC complex. Our in-depth mechanistic insights will likely have implications for the understanding of various pathological conditions and have the potential to contribute to the development of novel antibacterial compounds.

Keywords: smc proteins,condensin,cohesin,chromosome segregation,chromosome condensation,bacteria,dna replication,sister chromatid cohesion,dna protein interactions
Targeting oxidative repair proteins for treatment of cancer and inflammation (TAROX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-08-01
End date: 2021-07-31
Duration (months): 60.0
Total project cost (EUR): 2279406.0
EU funding (EUR): 2279406.0
Participants: 1
Project status: CLOSED

Oxidative damage and defects in DNA repair are frequently underlying many diseases, e.g., cancer, autoimmune diseases, ischemia/reperfusion injury, neurodegenerative disorders, viral diseases and ageing. Although some molecular understanding into oxidative DNA lesions and repair proteins exist, a thorough understanding on the link to diseases is largely missing, and therapies exploiting oxidative DNA damage and repair have not emerged. Here, we will study mechanisms of nucleotide metabolism and oxidative DNA damage and repair, and generate tools and make use of ‘omics’ approaches to explore the function of the Nudix and glycosylases family enzymes in relation to oxidative metabolism. Furthermore, we will progress and understand the basic mechanisms how oxidative DNA lesions are processed and kill cells. Importantly, we will develop small molecule inhibitors targeting Nudix and glycosylases, e.g. MTH1, NUDT15 and OGG1, and use our newly developed inhibitors to increase our knowledge of these enzymes in oxidative metabolism and disease. We will further optimize these inhibitors into drugs and explore therapeutic approaches in cancer and inflammation as well as in exploratory studies in a variety of diseases involving oxidative stress. Altogether, in this programme we contribute to deepen our knowledge into the fundamental biology of oxidative stress and its links with disease, and providing the scientific community with an innovative repertoire of selective inhibitors for numerous enzymes involved in repair of oxidative lesions. This will enable exploratory basic science discoveries as well as potential novel therapeutic interventions ‘outside the box’. The programme will also generate high value to the industrial competitiveness of Europe in form of novel inhibitors for treatment of diseases.

Keywords: oxidative dna damage,nudix,mth1,drug development,cancer theraphies
Toxicity of anthropogenic multi-stressed soils under a global warming perspective (GLOBALTOX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Portugal
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-02
End date: 2019-01-01
Duration (months): 24.0
Total project cost (EUR): 148635.6
EU funding (EUR): 148635.6
Participants: 1
Project status: CLOSED

Concept: Global climate change is displayed as a set of stressors (increasing temperature and CO2 levels, decreasing soil moisture content, higher UV radiation exposure) potentially impairing both biotic and abiotic ecosystem components. This may worsen in environments degraded by human activities where organisms have to deal with multiple stress factors, i.e. in multi-stressed environments, and the toxicity of the contaminants present may change depending on climate conditions. GLOBALTOX aims at assessing how the toxicity of anthropogenic multi-stressed soils may be affected under the current global warming perspective, using soil invertebrates as bioindicators along with soil physicochemical and microbiological parameters. Methodology: An inter/multidisciplinary ecotoxicological approach will be applied to soils from different environments with high human pressure (metal mining and agricultural areas), different soil invertebrate species (collembolans and enchytraeids) and single and multiple combinations of different climate factors (air temperature, soil moisture content, atmospheric CO2 concentrations and UV radiation). Climate factor combinations will be based on the emission scenarios predicted by the IPCC by the year 2100. For a complete overview of the problem, the project will rely on changes in key soil parameters (pH, organic matter, nutrient cycling, microbial community) and soil invertebrates (body metal concentrations, enzymatic biomarkers, DNA-damage, gene expression) to understand the effects at organism/population level (survival and reproduction). Impact: The foreground derived from the project will improve the environmental risk assessment of anthropogenic-degraded areas under future scenarios of climate change. GLOBALTOX will promote the social perception and awareness of anthropogenic contamination under a global warming perspective and the suitability of using soil invertebrates as bioindicators of toxicity changes.

Keywords: climate change,air temperature,soil moisture,atmospheric co2,uv radiation,contamination,anthropogenic degraded soils,ecotoxicology,soil invertebrates,exposure,multiple stress factors
Decentralised Citizens Owned Data Ecosystem (DECODE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Sweden,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Net Innovation Initiative (H2020-ICT-2016-1, 2016)
Start date: 2016-12-01
End date: 2019-12-31
Duration (months): 37.0
Total project cost (EUR): 4987673.75
EU funding (EUR): 4987673.75
Participants: 16
Project status: CLOSED

Today’s Internet is becoming increasingly centralised, slowing innovation and challenging its potential to revolutionise society and the economy in a pluralistic manner. DECODE will develop practical alternatives through the creation, evaluation and demonstration of a distributed and open architecture for managing online identity, personal and other data, and collective governance in a citizen-friendly and privacy-aware fashion. Strong digital rights that makes it possible for data subjects to determine access rights to their information through flexible entitlements and open standard-based agreements regarding data governance (on the model of Creative Commons licenses) will be woven into the technological architecture. DECODE will increase digital sovereignty of European citizens by enabling them to produce, access and control their data and exchange contextualised information in real-time, and in a confidential, and scalable manner. DECODE will develop a modular privacy-aware IoT hub with a free and open source operating system backed by a state of the art blockchain infrastructure supporting smart-contracts and privacy protections. The architecture will be demonstrated through four pilots in Barcelona and Amsterdam, in the field of digital democracy, citizen sensing, and collaborative economy. The pilots will be run with the active involvement of social entrepreneurs, hackers, and makers. Innovators will be able to build solutions on top of the platform through hackathons and open challenges, while ensuring their security, resilience and privacy preserving qualities. This aims to create a decentralised innovation ecosystem that will attract a critical mass able to shift the current centralised data-driven economy towards a decentralised, sustainable and commons-based economy. DECODE puts agency and data control in the hands of citizens, to improve citizens’ well-being and society for the collective benefit of all.

Keywords: distributed architectures,decentralised data management,privacy design strategy,digital sovereignty,open standards,blockchains,citizen owned data ecosystem
A Photothermal Lateral Flow Test for Visual Point of Care Detection (HOTFLOW)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-08-01
End date: 2019-01-31
Duration (months): 18.0
Total project cost (EUR): 149293.0
EU funding (EUR): 149293.0
Participants: 1
Project status: CLOSED

The rapid development of cost-effective and efficient biosensors has had a profound worldwide socioeconomic impact. Advances in the fields of microelectronics, materials science and nanotechnology have been vital to the implementation of enhanced sensing platforms aimed at providing alternatives to traditional analytical methods. Further, current sensing platforms are often slow, unreliable and expensive; in particular, when ultralow concentration detection is required. Although progress in the biosensors field typically focuses on clinical point-of-care diagnosis, a clear demand exists in areas such as food safety regulation, environmental policy, military and the arts, where time, cost, portability and ease-of-use of the device are critical. The grand aim of HOTFLOW is to develop an innovative, rapid, inexpensive, versatile and sensitive thermal transduction biosensor for the ultralow detection and quantification of relevant proteins such as tumoral markers. This novel sensing technology will use detection biomolecules linked to plasmonic gold nanoprisms which serve as thermal transducers by based on a lateral flow immunoassay and a “sandwich” recognition strategy with capture biomolecules immobilized on a dual-active nitrocellulose membrane support/thermosensitive paper that subsequently functions as photographic and tracing detection element. Although the ambitious thermal sensing device proposed here will be prototyped using simple analytes, this ERC POC project goes significantly beyond the current state-of-the-art in nanoplasmonics and biosensing by proposing the development and elaboration of an almost universal paper-based thermal sensing device. This technology will be implemented and validated by applying it to a specific problem, gastrointestinal cancer diagnosis.

Keywords: nanobiosensing,biosensor,photonics,nanoparticles,immunosensors,diagnosis
Integrated aquaculture based on sustainable water recirculating system for the Victoria Lake Basin (VicInAqua) (VicInAqua)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Uganda,Italy,Germany,Germany,Malta,Tanzania, United Republic of,Kenya,Denmark
Call: Development of water supply and sanitation technology, systems and tools, and/or methodologies (H2020-WATER-2015-two-stage, 2015)
Start date: 2016-06-01
End date: 2019-05-31
Duration (months): 36.0
Total project cost (EUR): 2997710.0
EU funding (EUR): 2997710.0
Participants: 12
Project status: CLOSED

VicInAqua will follow an integrated approach in order to develop a sustainable combined sanitation and recirculating aquaculture system (RAS) for wastewater treatment and reuse in agriculture in the Victoria Lake Basin area. In this decentralized integrated treatment system wastewater from households and fish processing industry as well as RAS production water will radically reduce stress on the sensitive ecosystems of the Lake Victoria and will contribute to food and health security. It will be operated fully autonomous powered by renewable energies (PV, biogas). The RAS will particularly produce high quality fingerlings of the local fish species to supply the pond aquaculture of the area with stocking material. The innovative core idea of the project is to develop and test new technologies which enable the integration of sanitation with the aquaculture in a sustainable manner. The core of the project concept is to develop and test a novel self-cleaning water filters which consist of a highly efficient particle filter as well as a membrane bioreactor (MBR) as principal treatment unit within a combined treatment system where the nutrient rich effluent water will be used for agricultural irrigation. the surplus sludge from both filter systems will be co-digested with agricultural waste and local water hyacinth to produce biogas. The overall concept will promote sound approaches to water management for agriculture, taking into consideration broader socio-economic factors and also fomenting job creation and greater gender balance in decision-making. The pursued approach will be perfectly in line with the strategic guidelines of the Rio+20 and the post-2015 development framework.

Keywords: sanitation,innovative water treatment,membrane bioreactor,lake victoria,fish ponds,closed recirculation aquaculture systems,water reuse,agriculture,renewable energy,capacity building
Development of Tagged (DIVA), Virus-Like-Particle polyantigenic Vaccine against Bovine Viral Diarrhea virus (BVDc) (BoVLP-BVD)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In a general context of environmental, social and legal pressure to reduce the use of antibiotics to fight diseases in livestock animals, cost-effective vaccination becomes the focus of most of the industry, regulatory and agro-food public bodies. Development of new vaccines to prevent the disease and therefore avoid the use of antibiotics or to improve suboptimal available vaccines is now an European and industry priority. Bovine viral diarrhea virus (BVDV) is an important infectious agent of cattle worldwide that affects herd productivity and reproduction. BVD has been and is an endemic disease in all countries where no systematic eradication and control programs have been established. Under these conditions, approximately 50% of the herds have or have had animals with persistent infection, and approximately 90% of the cattle have been exposed to the virus at some point during their lifetime.Infection with BVDV has a major economic impact, estimated in hundreds of euros per animal for a European hut of around 80 million animals. Modified, live and killed vaccines have been available for more than 50 years, yet the incidence of BVDV-induced disease remains significant, confirming a need for improved vaccines. Aquilón intends to develop a new recombinant vaccine against BVDV using a Virus-Like- Particle patented technology. The vaccine will be poly-antigenic, non-live, tagged so that can differentiate vaccinated from infected animals, and cost-effective from the manufacturing side. Prior to start the experimental phase of the project, Aquilón wishes to confirm its commercial feasibility, defining precisely the Target Product Profile and exploring systematically its market potential and prospective cost/calendar of development to fulfil regulatory requirements. These studies are mandatory for the formulation of a business plan which will be the basic tool to decide investing in the future development of the project.

Keywords: antibiotic free,virus like particle,bvdv,recombinant,vaccine,diva,lifestock,bovine vaccine,non live vaccine,cattle,respiratory disease,reproductive disease
Bimetallic Catalysis for Diverse Methane Functionalization (BECAME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1999679.0
EU funding (EUR): 1999679.0
Participants: 1
Project status: SIGNED

One of the remaining primary challenges in modern chemistry is the development of clean, energy- and cost-efficient catalytic processes that can allow to convert simple and abundant chemical feedstocks into high value-added products. Given the vast reserves of methane from natural gas, available worldwide, the direct use of the simplest alkane as source of fuels and chemicals could have a great impact in our society. However, methane´s low intrinsic reactivity has rendered its use extremely difficult for purposes beyond aerobic combustion and the production of syngas. Despite some recent advances in the field, a general strategy for a diverse and versatile use of methane is elusive. The overall aim of this proposal is the development of a new paradigm in catalysis which can provide new catalytic processes that allow direct methane functionalization by using it as a methylating reagent in a variety of C-C bond forming reactions. The approach described in this proposal is based on a cooperative interaction between two transition metal complexes in which an early transition metal is responsible for the methane C-H activation and a late transition metal is the actual catalyst of the methylation process. The link between these two processes is a transmetalation step and will be used to transfer the mechanism of typical cross-coupling reactions to the field of methane functionalization. New pathways for the direct use of methane in reactions such as allylic alkylation, conjugate addition, cross-coupling, C-H methylation and alkene hydromethylation will be developed based on this novel bimetallic catalytic strategy. It is envisioned that the proposed research will lead to a new concept at the interface of catalytic cross coupling reactions and C-H activation. It will contribute to the fundamental understanding of these two reactions and will provide the basis for a new technology for energy efficient and environmentally friendly, thus sustainable, methane conversion.

Keywords: organometallic chemistry
Provizio Accident Prevention Technology™ Platform (P-APT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-07-01
End date: 2022-06-30
Duration (months): 24.0
Total project cost (EUR): 3571375.0
EU funding (EUR): 2499962.5
Participants: 1
Project status: CLOSED

Provizio is radically transforming vehicle safety with our proprietary Accident Prevention Technology (APT) platform. Human error is the fault in 90% of car accidents. Over 1.35 million people are killed every year on the road (equivalent to 20 airplane crashes every single day) + 50 million injuries [World Health Organisation] = a cost USD $24 trillion (2%+ of worldwide GDP) [International Road Assessment Programme, iRAP] . More than $80 billion has been invested in ADAS over the last 5 years [Brookings Institute]…with zero impact on road deaths. Provizio was founded by a team of automotive and aerospace industry veterans with a mission to use advanced technology to reduce the devastation caused by road accidents. Our skill sets include entrepreneurship, scaling start-ups to exit, VC fund raising, building strong defensible IP portfolios as well as an enviable track record in developing the most advanced technology in automotive radar. This proposal outlines the further development of the APT Platform. APT combines proprietary vision sensors and machine learning to see further, wider and through obstacles, detecting danger in all-weather conditions and applying predictive analytics in real time to augment driver behaviour…and prevent accidents.

Keywords: safety,radar,accident prevention,augmented driving,autonomous,adas