Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Novel Prognostic Personalized Biomarker and Therapeutic Target in Blood Cancer Related Fibrosis (de-ALARMIN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Netherlands
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The objective of this ERC Proof of Concept is to demonstrate the clinical application and commercial viability of a specific driver of the innate immune system as a novel predictive biomarker and as a novel therapeutic target for the diagnosis and treatment of bone marrow fibrosis related to blood cancer. This proposed project builds upon recent findings of my deFiber ERC Starting Grant (Stg) project, where we identified this danger-associated molecular pattern complex as exactly as such a prognostic and predictive biomarker and importantly showed that targeting with a small molecular, oral, anti-cancer inhibitor reduced fibrosis but also the cancer cell burden, in the sense of a targetable biomarker.

Keywords: blood cancer,biomarker,personalized therapy,targeted therapy,fibrosis,bone marrow,hematopoietic stem cells,inflammation,drug repurposing
Development of a new plant variety for the Asian market (REDSTEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-03-01
End date: 2016-08-31
Duration (months): 18.0
Total project cost (EUR): 148307.0
EU funding (EUR): 148307.0
Participants: 1
Project status: CLOSED

Palms are some of the most successfully traded plants, with numerous species sold for indoor, outdoors and as crops. The kentia palm (Howea forsteriana), is one of the most widely exported houseplants in the world and is worth over seven million euros per year in the Dutch horticultural industry alone. Wild kentias are only found on a 12km2 island in the middle of the Tasman Sea, Lord Howe Island (LHI). LHI is a unique ecosystem. It is the focus of the applicant's ERC Advanced Grant, who is using the kentia palms as a model to tackle 'Darwin's mystery of mysteries'. During our expeditions on LHI, we have also discovered a new mutant variety of the kentia palm: instead of having the typical dark green colouration, it has a bright red stem. Red-stemmed varieties of palms are known, but have had very limited commercialisation due to climatic restrictions: these palms are tropical species, requiring high humidity and temperature. In contrasts, kentias are very hardy and grow well under low light and cool temperatures, hence their immense success as decorative items across innumerable indoor public venues and households. In addition, red is an auspicious colour in Asia – and we know our new red kentia palm has tremendous horticulture potential. Building on our genetic research and experiments with these kentia palms, we propose to disentangle the biological underpinning of the red stem. In parallel, we will conduct a market research. Examining our IPR position and strategy, we will take the necessary steps to protect our variety, including its registration as Ornamental Crop to the Community Plant Variety Office. Finally, we will strengthen our links with various industries and private stakeholders to develop a business plan for commercialisation of red kentias

Keywords: plant breeders rights,horticulture,palm,asia
European researchers' Night in Cyprus: the diGitAl and Green Age (ENGAGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Cyprus
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020bis, 2020)
Start date: 2021-04-26
End date: 2022-02-25
Duration (months): 10.0
Total project cost (EUR): 143750.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The ENGAGE proposal aims at organising a European Researchers' Night (ERN) in Nicosia, Cyprus on the 24th of September 2021. The theme of the event, the green and digital age, focusses on the transition towards a green world led by the European Union (EU) through the European Green Deal, in a new decade where the digital transition is well under way and more prominent than ever before as addressed in the European Digital Strategy. Having coordinated the organisation of the ERN events in Cyprus since 2006, the Research and Innovation Foundation (RIF), will seek to build on the experience accumulated over the years and established collaboration with local Research and Innovation (R&I) stakeholders from the academia, the public sector, industry as well as other actors in civil society to make the event a success. The proposal's main objective is to mobilise and actively engage researchers in a quest to increase awareness of research and innovation activities by bringing them closer to the wider public. ENGAGE will additionally seek to raise the public's awareness regarding the latest R&I achievements in Cyprus and the EU, creating an understanding of the benefits and impact of researchers' work on citizens' daily life, whilst at the same time reducing stereotypes about researchers and encouraging young people to embark on research careers. The target audience for the event is the public at large, attracting people regardless of their age, gender or scientific background, with a special focus on families, pupils and students. Activities will bring together the public and researchers from all sectors and disciplines, and include side events such as a European Corner Roadshow in the main cities of Cyprus and a main event with hands-on experiments and demonstrations, games, live science communication competitions and quizzes as well as screenings of science documentaries, a Stand-up Science Comedy Live Show and a digital concert to conclude festivities.

Keywords: european researchers night,science communication,research careers,science for all
Materials for Quantum Computing (MATQu)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Research and Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Austria,Germany,Germany,Germany,Israel,Germany,Finland,Belgium,France,France,France,France,Netherlands
Call: ECSEL-2020-2-RIA (H2020-ECSEL-2020-2-RIA-two-stage, 2020)
Start date: 2021-06-01
End date: 2024-05-31
Duration (months): 36.0
Total project cost (EUR): 21707010.0
EU funding (EUR): 6548524.39
Participants: 18
Project status: SIGNED

Over the past 60+ years CMOS-based digital computing has giving rise to ever-greater computational performance, „big data“-based business models and the accelerating digital transformation of modern economies. However, the ever-growing amounts of data to be handled and the increasing complexity of today’s tasks for high performance computing (HPC) are becoming unmanageable as the data handling and energy consumption of HPCs, server farms and cloud services grow to unsustainable levels. New concepts and technologies are needed. One such HPC technology is Quantum computing (QC). QC utilizes so-called quantum bits (qubits) to perform complex calculations fundamentally much faster than a conventional digital-bit computers can. First quantum computer prototypes have been created. Superconducting Josephson junctions (SJJs) have been shown to be extremely promising qubit candidates to achieve a significant nonlinear increase of computational power with the number of qubits. For novel materials there is a great challenge yet opportunity in Europe to create a complete value chain for SSJs and QCs. Such a complete value chain will contribute to Europe’s technology sovereignty. The MATQu project aims at validating the technology options to produce SJJs on industrial 300 mm silicon-based process flows. It covers substrate technology, superconducting metals, resonators, through-wafer-via holes, 3D integration, and variability characterization. These will be assessed with respect to integration practices of qubits. Core substrate and process technologies with high quality factors, improved material deposition on large-substrates, and increased critical temperature for superconducting operation, will be developed and validated. The MATQu partners complement each other in an optimal way across the value chain to create a substantial competitive advantage, e.g. faster time-to-market and roll-out of technologies and materials for better Josephson junctions for quantum computing.

Keywords: quantum computing
Precision Farming of Hazelnut Orchards (PANTHEON)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Belgium,Luxembourg
Call: Robotics Advances for Precision Farming (H2020-SFS-2017-1, 2017)
Start date: 2017-11-01
End date: 2021-10-31
Duration (months): 48.0
Total project cost (EUR): 3144452.5
EU funding (EUR): 3144452.5
Participants: 6
Project status: CLOSED

The goal of PANtHEOn is to develop the agricultural equivalent of an industrial Supervisory Control And Data Acquisition (SCADA) system to be used for the precision farming of large orchards of hazelnut (Corylus avellana L.). By taking advantage of the technological advancements in the fields of robotics, remote sensing and big-data management, our objective is to design an integrated system where a relatively limited number of heterogeneous unmanned robotics components (including terrestrial and aerial robots) move within the orchards to collect data and perform some of the most common farming operations. The information will be stored in a central operative unit that will integrate the data coming from the different robotic units to perform automatic feedback actions (e.g. to regulate the irrigation system) and to support the decisions of agronomists and farmers. We expect that the proposed SCADA system will be able to acquire information at the resolution of the single plant. This will permit to drastically increase the detection of possible limiting factors for each individual plant, such as lack of water or pests and diseases affecting the plant health, and to react accordingly. Compared to the current state of the art in precision farming, we believe that the proposed SCADA infrastructure represents a relevant step ahead in the context of orchards management. In fact, the capability of monitoring the state and the evolution of each single tree will be the enabling-technology to allow more focused interventions. This will result in a better average state of health of the orchard, and in an increased effectiveness of Integrated Pest Managements (IPM). In conclusion, the main advantages of this architecture are: • Increase in hazelnut productions • Decrease in chemical inputs usage • Environmentally-friendly water usage • Simplified orchard management The outcome of the project will be validated through a final demo on a real-world (1:1 scale) hazelnut orchard.

Keywords: scada systems,remote sensing,control theory,big data management,orchards management
Crime and Time: How short-term mindsets encourage crime and how the future self can prevent it (CRIMETIME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Germany,Netherlands,Netherlands
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2024-03-31
Duration (months): 72.0
Total project cost (EUR): 1763690.0
EU funding (EUR): 373750.0
Participants: 3
Project status: SIGNED

Why are some people more likely to commit crime than others? Answers to this question, which is at the heart of criminology, can be grouped into two broad views. On the one hand, dispositional perspectives argue that stable factors within the individual, such as lack of self-control, lie at the roots of criminal conduct. Sociogenic perspectives, on the other hand, put the locus of study outside the individual and point towards factors such as rough neighborhoods, parental unemployment, and deviant peers, as the main causes of crime. In spite of ample empirical support for both views, there has been relatively little constructive engagement with each other. Capitalizing on my multidisciplinary background and drawing on social psychology and evolutionary theory, I outline a new perspective on criminal behavior –Time Frame Theory (TFT)– that integrates both views. TFT is premised on the idea that short-term mindsets encourage crime and specifies how both individual dispositions and sociogenic variables can encourage such mindsets. I test this theory using a combination of longitudinal research and behavioral field experiments. Besides aiming to mend the current theoretical disconnect in criminology and providing the foundation for a common paradigm, the proposed research program goes a step further by using TFT as the basis for a behavioral intervention to reduce crime. Building on recent pilot research, I use virtual reality technology in combination with a smartphone application to instill a future-oriented mindset in offenders. I am convinced that this combination of novel theory and innovative methodology may lead not only to a breakthrough in our understanding of delinquency but can also provide a blueprint for a scalable and evidence-based intervention to reduce it.

Keywords: crime,delinquency,future self,self control
Development of the first fully biocompatible, soft actuated heart: combining in situ tissue engineering and soft robotics (HybridHeart)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Germany,Germany,Netherlands,Netherlands,Netherlands
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2017-11-01
End date: 2023-04-30
Duration (months): 66.0
Total project cost (EUR): 3035550.0
EU funding (EUR): 3035550.0
Participants: 9
Project status: SIGNED

The Hybrid Heart consortium envisions to develop and bring to the clinic soft biocompatible artificial organs. These will consist of a soft robotics shell with actuators (‘artificial muscles’) and sensors, enabling completely natural motion. The inner lining and structures will be made by in situ tissue engineering (TE), ensuring biocompatibility of blood-contacting surfaces. As the first step, the consortium will develop the Hybrid Heart, which can completely replace a patient’s heart in a procedure similar to a heart transplant, to provide a cure for heart failure, which affects ~23 million people worldwide. Currently, patients with end-stage heart failure either receive a heart transplant, if available, or long-term mechanical circulatory support, which causes severe complications. To achieve the ambitious goal of providing a permanent cure for these patients, the participants will, in parallel, develop the components of the Hybrid Heart: 1) a soft elastomeric robotics shell containing actuators and sensors, 2) scaffolds for in situ TE of inner lining, valves and vessels and 3) a wireless energy transfer system. These components together will form the full Hybrid Heart, which will be soft, adaptable, wireless and fully bio- and hemocompatible. Both functionality as well as biocompatibility of the Hybrid Heart will be shown in a Proof-of-Principle study in the chronic sheep model at the end of the project. The Hybrid Heart project will be carried out by an interdisciplinary group of (academic) researchers and high-tech SMEs, with experience in cardiac surgery, TE, soft robotics and engineering. The technology underlying the Hybrid Heart is applicable to a range of soft robotics-based artificial organs, including the bowel, lung, or muscle structures (limbs). Replacing an entire organ with bioinspired robotic elements, TE biocompatible surfaces, artificial sensors, and an external power source allows for an off-the-shelf therapy for patients with organ failure.

Keywords: artificial heart,in situ tissue engineering,soft robotics,wireless energy transfer
Advanced in vitro physiological models: Towards real-scale, biomimetic and biohybrid barriers-on-a-chip (BBBhybrid)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-04-01
End date: 2020-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

This project is focused on the design, the production, the characterization, and the proposal for future commercialization of the first 1:1 scale 3D-printed realistic model of the brain tumor microenvironment with its associated blood neurovasculature. The proposed biomimetic dynamic 3D system, characterized by microcapillary diameter size and fluid flows similar to the in vivo physiological parameters, represents a drastic innovation with respect to other models well-established in the literature and available on the market, since it will allow to reliably reproduce the physiological environment and to accurately estimate the amount of drugs and/or of nanomaterial-associated compounds delivered through a modular length of the system. At the same time, in vitro 3D models are envisioned, allowing more physiologically-relevant information and predictive data to be obtained. All the artificial components will be fabricated through advanced lithography techniques based on two-photon polymerization (2pp), a disrupting mesoscale manufacturing approach which allows the fast fabrication of low-cost structures with nanometer resolution and great levels of reproducibility/accuracy. The proposed platform can be easily adopted in cell biology laboratories as multi-compartmental scaffold for the development of advanced co-culture systems, the primary biomedical applications of which consist in high-throughput screening of brain drugs and in testing of the efficacy of different anticancer therapies in vitro.

Keywords: organ on chip,drug screening,in vitro models,neurological diseases
Enabling the continuous monitoring of drinking water with an all-in-one sensor (CENSE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-11-01
End date: 2022-08-31
Duration (months): 34.0
Total project cost (EUR): 2035250.0
EU funding (EUR): 1424675.0
Participants: 1
Project status: CLOSED

The CENSE Integral probe combines 5 water quality monitoring sensors in one: temperature, turbidity, pressure, conductivity and chlorine. The chlorine sensor developed by the CENSE team is a brand-new technology based on a microfluidic lab-on-chip. This new technology is far more affordable than the more standard colorimetric and amperometric methods; it is also much less hazardous to handle and can withstand high pressures and challenging conditions. Installation costs are low and the time taken to replace an amperometric sensor with the Integral probe is minimal. EFS listened to and answered the needs of its customers – there has been a lot of demand for a high-performance low-cost chlorine sensor within the drinking water sector. The feasibility studies have shown that uptake of the new probe will be large, and its release is much anticipated. EFS have already gained trust within the drinking water sector, thanks to the success of their previous water probes. Sales will be made via direct sales and indirect sales, through EFS’ extensive distributor network. The team working on CENSE are experienced and have brought multiple water probes and water sensing technologies from lab to market already. The new technology will be rolled out initially in France, Germany, Italy Spain and the UK. France was chosen to be the kick-off point for several reasons: first of all EFS is based in France and has a strong network there, and secondly France is home to several global market leaders in drinking water provision: VEOLIA, AQUALTER and SUEZ, to name a few. From year 3 the product will be launched in the rest of the EU with a global launch beginning year 5.

Keywords: water quality,chlorine,monitoring,sensor