Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Label-free fluorescence lifetime analysis for the screening of nanoencapsulated drugs (enLIGHT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-10-01
End date: 2027-03-31
Duration (months): 18.0
Total project cost (EUR): 165000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: SIGNED

Nanomedicine has the potential to revolutionize healthcare by enabling targeted drug delivery, reducing side effects, and improving treatment efficacy. However, the field faces a critical bottleneck: the lack of efficient, non-invasive analytical tools to assess drug encapsulation, stability, and release dynamics in nanoformulations. Current techniques rely on destructive, time-consuming methods, limiting their applicability in formulation development and quality control. enLIGHT introduces a breakthrough approach—a patented, label-free fluorescence lifetime-based screening technology that provides real-time, quantitative insights into the physical state of encapsulated drugs. By leveraging exploitation of the intrinsic luminescence of drugs and a phasor-based, fit-free and purely graphical analysis, enLIGHT eliminates the need for fluorescent labeling or complex sample preparation, offering a rapid, cost-effective, and non-destructive alternative to traditional characterization techniques. Validated in laboratory settings, enLIGHT has already revealed unexpected drug behaviors in FDA-approved nanomedicines, demonstrating its ability to uncover hidden formulation instabilities. This Proof of Concept project aims to move enLIGHT from a complex lab setup to a compact, user-friendly device for pharmaceutical and research laboratories. By refining the prototype and validating its performance across diverse nanoformulations, the project will establish enLIGHT as an indispensable tool in nanomedicine analytics. With its potential to enhance drug development pipelines, reduce formulation failures, and streamline regulatory approval processes, enLIGHT represents a transformative innovation for the pharmaceutical industry—ensuring more stable, effective, and safer nanomedicines for the future.
Ontological diversity in environmental education (ODEEN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 2
Project status: SIGNED

Working as an environmental education (EE) facilitator I can attest to the fact that a feeling of urgency, detachment, helplessness and lack of alternatives tends to be a common reaction when working with EE in the European context. This has led me to question the factors that influence the learning process within EE. Building on my past work on ideological and epistemological blockages to effective social change, this project will utilize the concept of ontology as a more encompassing term for social analysis. Based on analytical frameworks on secularism, religion and climate change developed within the Faculty of Theology and Religious Studies at Groningen University, together with transdisciplinary currents of thought such as political ontology and agroecology, in the proposed research I will study the role of ontological diversity in environmental education (EE) utilizing concepts and methods from the field of theology and religious studies (TRS). Framing the research within TRS will allow us to find a critical perspective on the dominant secular-scientific tradition behind EE policy and implementation, as well as the presumed secularity-based ontological homogeneity of EE in Western and Westernized contexts. In this research we will explore if the effectiveness of European environmental education is being hindered by lack of ontological diversity, together with ways in which TRS can contribute to fostering ontological diversity (OD) within EE. I will be focusing on EE in the contexts of Barcelona (Spain) and Havana (Cuba) using literature review, expert interviews, critical discourse analysis, grounded theory, good practice analysis and participatory action-research (PAR) in order to develop four scientific articles on OD in EE, a handbook for EE practitioners, a handbook for policy makers, and policy recommendations for EU GreenComp implementation.

Keywords: ontological diversity environmental education greencomp participatory action research spain cuba
Novel enzymes from extreme marine environments as a source for value-added targets (NEXTMARINE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Research and Innovation actions
Countries involved: Greece,Germany,Denmark,Slovakia,Poland,Belgium,Spain,Sweden,France
Call: Targeting aquatic extremophiles for sourcing novel enzymes, drugs, metabolites and chemicals (HORIZON-CL6-2024-CIRCBIO-01, 2024)
Start date: 2025-11-01
End date: 2029-10-31
Duration (months): 48.0
Total project cost (EUR): 4496933.75
EU funding (EUR): 4496933.75
Participants: 12
Project status: SIGNED

In Europe, physicochemically extreme environments, such as the volcanic arc in the Mediterranean Aegean Sea, as well as anoxic zones and ammunition dump sites in the Baltic Sea, serve as extreme ecosystems that selectively favors various extremophilic microorganisms. The central tenet of the proposed research is that the extremophiles play important roles in the cycling of nutrients and chemical elements in these environments, representing a vast genetic source of enzymes with high industrial application potential, which needs to be explored. The proposed research involves applying innovative sampling method that use novel remotely operated underwater vehicles at these extreme environments, and conducting investigative exploration of the sites through underwater hyperspectral cameras, imaging measurements, and robotic sensing technologies. These activities will advance both the fundamental understanding of the extreme ecosystems and will supply a wide range of unique samples for exploration and discovery of novel enzymes. The enzymes will be identified and characterized using cutting-edge gene sequencing technologies, bioinformatics, artificial-intelligence tools for structural and functional comparisons, and high-throughput methods. Furthermore, new enzyme production intensification and up-scaling methods will be employed to provide both a range of novel, unique halogenases for manufacture of new pharmaceutical compounds, and an array of carbohydrate processing enzymes for seaweed and chitin biorefining to provide new value-added compounds (alginates, fucoidans, chitin-derivatives) for pharmaceutical, biomaterial and food applications. The program includes a targeted dissemination plan to share of high-impact research results, along with extensive communication efforts aiming the general public, non-governmental organizations, and regional development agencies. These initiatives collectively contribute to conservation and protection of the marine genetic diversity.

Keywords: enzyme discovery,marine polysaccharides,metagenomic bioprospecting,extreme environments,valorization,oligosaccharides
Molecular gated Eco-MOFs for anti-cancer drug delivery (GateMOF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-05
End date: 2027-02-04
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Cancer is a major societal challenge, as reflected by Horizon's Europe mission on cancer and Europe's Beating Cancer Plan. In particular, despite great advances in cancer treatment in recent decades, its treatment still remains a challenge without an effective cure. In 2020 the EU reported around 3 million new cancer cases and more than 1.2 million deaths, and its incidence is expected to increase in Europe due to its aging population. The standard treatment relies on the systemic administration of chemotherapeutics, which has limited efficacy and causes side effects. To overcome current limitations, GateMOF will develop low-toxicity Molecular Organic Frameworks (MOFs) as advanced nanosystems to tackle cancer. Such Eco-MOFs will be equipped with molecular gates and loaded with anticancer drugs resulting in advanced biocompatible nanosystems with the ability to respond to stimuli present in the tumor intracellular/microenvironment for a selective anticancer drug delivery. The project combines the unique expertise of the host laboratory (Supramolecular Chemistry and Biotechnology) and the candidate (MOF design and synthesis) to ensure the fulfillment of objectives. The fellow will be trained in advanced nanomaterial preparation with molecular gates to obtain stimuli-responsive MOFs for anti-cancer drug delivery, including training for biological studies for their evaluation in vitro in cells and in vivo in animal models. Notably, the project will also allow the fellow to gain experience in patenting and tech transfer. Altogether, GateMOF will develop a new therapeutic technology and provide the fellow with complementary scientific and transferable skills with a significant impact toward an independent research career.

Keywords: nanosystems,nanomedicine,anti tumour effect,metal organic frameworks mof,drug delivery,cancer
fuTure pRoof efficient and sUSTainable dEployment of zEwt (TRUSTEE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Coordination and support actions
Partnership: ZEWT (co-programmed)
Countries involved: Italy,Germany,Spain
Call: Structuring the Waterborne transport sector, including through changed business and industrial models in order to achieve commercial zero-emission waterborne transport (ZEWT Partnership) (HORIZON-CL5-2024-D5-01, 2024)
Start date: 2025-02-01
End date: 2028-01-31
Duration (months): 36.0
Total project cost (EUR): 929836.88
EU funding (EUR): 849999.38
Participants: 7
Project status: SIGNED

TRUSTEE project aims at supporting the European roadmap to deploy the ZEWT providing the decision makers and the wide stakeholders community with a comprehensive and science-based set of knowledge and recommendations built on an evidence based approach, founded on: - clarity and comprehensiveness of foresight scenarios in 2030 and 2050 where ZEWT will be deployed - a comparative multidimensional assessment framework incorporating environmental, social, technological, financial and operational aspects, including safety and security aspects for workforce and citizens - a robust validation roadmap with an equitable representation of direct and indirect stakeholders. TRUSTEE is built on the following objectives: - Define and validate future European ZEWT wide ecosystem at 2030 and 2050 time horizons through foresight scenarios - Detail and validate the most promising ZEWT Use Cases for the 2030 and 2050 target horizons - Build and validate a multi-stakeholders and cross-sectorial assessment framework for system components and overall ecosystems underpinning the Zero Emissions target in the European water transport sector - Identify systemic and sectorial barriers challenging the ZWET targets and defining recommendations for its timely deployment - Create a common knowledge background among all direct and indirect stakeholders for ZEWT targets timely achievement. Thanks to a consortium with relevant expertise and strong institutional liaison with all the ZEWT stakeholders, TRUSTEE will achieve the desired impact delivering actionable Open Access Results: - ZEWT 2030 and 2050 foresight scenarios - ZEWT technology readiness review - Comparative analysis framework for ZEWT use cases assessment, combining environmental, technical integration, operational, societal and financial indicators - ZEWT barrier analysis - Most promising ZEWT Use Cases - Recommendations for ZEWT standards, regulations and policy development - ZEWT open access learning pack.

Keywords: foresight scenarios technology readiness review comparative analysis barriers,use cases,leraning pack
Seafloor spreading on Short And Long Time scales (SeaSALT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1999804.0
EU funding (EUR): 1999804.0
Participants: 1
Project status: SIGNED

Seafloor spreading is the process that single-handedly shapes 2/3 of our planet, modulates the dynamics of deep ocean currents, controls the composition of seawater, and supports unique ecosystems that thrive in extreme environments. Discovered in the 1960s, it is now explained as the slow and steady divergence of 2 tectonic plates accommodated by magma emplacement and faulting at a mid-ocean ridge axis. In the current paradigm, the texture of the seafloor is primarily determined by the magmatically-accommodated fraction (M) of plate separation at the ridge axis. However, we do not know what sets the M fraction in the first place, and why it is subject to spatiotemporal fluctuations that can cause drastic shifts in seafloor spreading regimes. SeaSALT tackles this issue by rethinking seafloor spreading as a succession of discrete magmatic and tectonic events which, by inhibiting or triggering one another, self-consistently distribute magmatic and tectonic strain. To test this hypothesis, we will design brand-new simulations of seismo-volcanic cycles in which dike intrusions, earthquakes, or aseismic slip transients may occur in response to far-field extension and pressurization of a shallow magma reservoir. Each component of the model will be constrained by groundbreaking observations of seafloor spreading events and inter-event stress build-up at 3 target sites. This includes the most ambitious seafloor seismo-geodesy experiment to date across a ridge axis, and the development of a novel “hydrothermal geodesy” method that constrains sub-seafloor stress changes via the perturbations they impart on black smoker temperatures. The success of our new framework will be indexed on its ability to spontaneously generate the types of events documented at each site, while accounting for the M fraction and its multiscale variability, as recorded in high-resolution bathymetry. It will also help forecast hazards to rift populations and key submarine infrastructure.

Keywords: seafloor spreading mid ocean ridges faulting magmatism hydrothermal circulation
JWST Breakthrough in Galaxy Formation: Mass Build-up Efficiency at Cosmic Dawn (SFEER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 1979422.5
EU funding (EUR): 1979422.5
Participants: 1
Project status: SIGNED

We present SFEER (Star Formation Efficiency in the Epoch of Reionization), an ambitious project to enable one of the most significant and long-lasting leaps in our understanding of early galaxy formation. The discovery of exceptionally massive galaxies in the distant Universe has confronted us with puzzling questions about how galaxies could assemble so efficiently at early cosmic times. Unfortunately, significant instrumental limitations have prevented us from robustly reconstructing their physical properties. The recent launch of the James Webb Space Telescope (JWST) has ignited a revolution. Its exquisite sensitivity and spatial resolution are going to provide dramatically new information on massive galaxies in the the Epoch of Reionization (EoR) and beyond. SFEER is set to play a dominant role in this process. At its core is a cycle 1 JWST/NIRSpec program I am leading which will obtain spatially resolved spectroscopy for 12 exceptionally bright galaxies in the EoR. Remarkably, estimates of the interstellar medium (ISM) reservoirs of this sample are already in our hands thanks to recent Atacama Large Millimeter Array (ALMA) observations, providing information on their molecular gas and dust content, and the fraction of obscured star formation. This joint dataset clearly stands out in the panorama of current JWST programs, and constitutes an important benchmark. SFEER will enable to probe the assembly history of these tantalizing objects through the characterization of their ages, stellar mass, energy-balanced star-formation rates, metallicity, merging fractions and gas kinematics, and their relationship with the host dark matter halos. Taking advantage of complementary JWST programs and wide-area multi-wavelength data from ground and Euclid, we will extend our results to higher and lower masses, and probe galaxy formation from the earliest points in cosmic time.

Keywords: high redshift galaxies,epoch of reionization,lyman break galaxies,galaxy stellar populations
Bio-based, repairable and recyclable vitrimer composites and advanced sensors for highly reliable and sustainable wind blades (EOLIAN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Italy,Türkiye,United Kingdom,Belgium,Spain
Call: Critical technologies to improve the lifetime, efficient decommissioning and increase the circularity of offshore and onshore wind energy systems (HORIZON-CL5-2023-D3-02, 2023)
Start date: 2024-06-01
End date: 2027-11-30
Duration (months): 42.0
Total project cost (EUR): 3653176.25
EU funding (EUR): 3653176.25
Participants: 11
Project status: SIGNED

Today 2.5 million tonnes of composite material are in use in the wind energy sector globally. Wind turbine blades are made up of composite materials that allow lighter and longer blades with optimised aerodynamic shape, which boost the performance of wind energy. However, current wind blade composites exhibit relatively short life spans, are problematic to repair and are notoriously difficult to recycle. As we continue to build more wind farms these issues pose a major problem to achieving a truly sustainable European wind energy sector. The EOLIAN project will develop an innovative new smart wind turbine blade, manufactured from an infinitely recyclable circular platform chemistry, with in-mould electronics (recyclable sensors and heating actuators) that detect damage early before it becomes a major issue. EOLIAN is the breakthrough that will make obsolete single-use engineering resins in wind blade manufacture. Our unique blade is made using vitrimers, a new class of polymer combining the performance of thermosets with the processability and logistical benefits of thermoplastics. Vitrimer resins enable circularly recyclable composite structures (1), and the option of post-cure processing provides unprecedented manufacturing flexibility (2), but also repairability (3). These three features will provide a truly sustainable and step-change approach in how wind turbine blades are maintained, re-shaped for new applications and/or recycled in a circular economy. In the project we will validate these performance claims through the manufacture, testing and benchmarking of a smart sensor-assisted vitrimer-based composite 14m prototyped wind blade. Additionally, we will prove circular recyclability through the manufacture of 2nd generation composites with (i) recycled fibers and recycled vitrimer obtained after the chemical recycling by vacuum infusion; (ii) with composite parts produced by SMC (Sheet Mould Compound) following mechanical recycling.

Keywords: circular economy,circular recycling,vitrimers,bio based vitrimer epoxy,vitrimer composites,condition monitoring,materials reuse,materials recovery,natural fibers,basalt fibers,bio based vitr
Paradigm shift in breast cancer management (Resitu Slider)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2400000.0
EU funding (EUR): 2400000.0
Participants: 1
Project status: SIGNED

Over 2.3 million women are diagnosed with breast cancer every year. It is by far the most common form of cancer in women, globally affecting one in every eight. The incidence continues to rise and mortality is high. Open surgery to remove a breast lesion is costly and increasing healthcare costs have accelerated the need for minimally invasive alternatives to remove breast tumors rather than open surgery. Resitu Medical has developed the Resitu Slider, a novel medical device that offers a potential paradigm shift in breast cancer management. Its minimal invasive approach provides a new method to replace biopsy harvesting and open surgery. Resitus business model is a stepwise strategy to get regulatory clearances, escalate claims and reach a global market. It is based on achieving regulatory approval for Resitu Slider with the lowest risk claims first (breast biopsy) and use this release as a springboard to gather safety evidence for escalated claims (cancerous tumor removal) of a subsequent release. The business model is highly scalable with initial market launch in selected EU countries and the US immediately after market clearance followed by a global launch, with a projected annual revenue of €30 M by 2030. The uniquely large diameter of Resitu Slider enables removal of an intact lesion identified by x-ray under ultrasound guidance with sufficient safety margins of healthy tissue surrounding the lesion. All performed in one single procedure and a surgical setting is not required. The technologys potential is also clear for several other disciplines including lymph nodes, thyroid & prostate lesions, neurosurgical indications. The Resitu team has a broad, extensive experience in all aspects of Medtech development and commercialization, which, combined with close collaboration with key international KOLs and surgical experts, for a strong user perspective, will introduce Resitu Slider to the market as a revolutionary instrument for tumor removal from the breast.

Keywords: breast cancer,minimally invasive surgery,breast lesion removal,health economics