Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
HERCCULES: HEROES IN SOUTHERN EUROPE TO DECARBONIZE INDUSTRY WITH CCUS (HERCCULES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Italy,Spain,Germany,Netherlands,Austria,Ukraine,Estonia,Finland,Greece,France,Poland
Call: Decarbonising industry with CCUS (HORIZON-CL5-2022-D3-01, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 39654395.53
EU funding (EUR): 29632076.48
Participants: 31
Project status: SIGNED

HERCCULES aims at defining a first-of-a-kind, integrated and replicable approach for the implementation of the whole CCUS chain to two strategic sectors of the circular economy - Cement and Energy-from-Waste (EfW) – in an area – Italy and Greece – where the industrial promise of CCUS is largely unexplored. Leveraging on the potential of two clusters of emitters in Northern Italy (cement + EfW) and Greece (cement), HERCCULES will pave the way towards the implementation of the first full-scale CCUS chain in Southern Europe. Technological, infrastructural, safety, societal, regulatory and financial issues will be addressed by a multidisciplinary approach to build an “HERCCULES paradigm” comprising nine basic chapters. 1) TRL7-8 demonstration of 2 flexible and retrofittable CO2 capture technologies, to be tested in 2 large-scale cement plants + 1 EfW plant with residual waste/biomass feed to approach nearly zero or negative emissions (>9000 h of tests). 2) Design of the optimal CO2 transport network for utilization and storage under different infrastructural evolution scenarios. 3) TRL8 Geological storage of captured CO2 in the two most advanced CO2 sites in Southern Europe (Prinos and Ravenna). 4) Demonstration in industrial environment of novel CO2 mineralization solutions and re-use technologies for the production of a breakthrough hydraulic binder enabling the industrial production of a carbon-sink concrete (>1000 h of tests). 5) Experimentally-supported, Techno-Economic Analyses with risk assessment to ensure the safety of the full CCUS chain. 6) Advancement of societal readiness through a participative approach. 7) Identification of business models and financial mechanisms tailored to CCUS. 8) TRL8-9 pre-FEED studies on the most promising HERCCULES implementation options. 9) Ad-hoc case studies to verify the replicability of the HERCCULES paradigm. Know-how, data and models will converge into a dedicated exploitation plan to seed CCUS across Europe.

Keywords: cement,energy from waste,retrofitting,calcium looping,oxyfuel,waste management,chain optimization
Beyond Bones: Integrating Statistics and Machine Learning Tools into Archaeological Evidence to Decode Neanderthal-Carnivore Scenarios (BITES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Portugal,Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 2
Project status: SIGNED

The relationship between humans and their natural environment has significantly shaped our evolutionary history. Carnivores in particular, our main competitors in many past ecosystems, likely had a profound impact on hominin behaviours. Neanderthals, potentially more carnivorous than other hominin species, present an intriguing focus. Were the relationships between Neanderthals and carnivores primarily rooted in rivalry, mutual avoidance, or subtle survival adaptations? How did they impact Neanderthal niche exploitation? Can changes in these interactions shed light on Neanderthal disappearance? Archaeological sites yield thousands of animal bone fragments with traces of Neanderthal and carnivore consumption that offer valuable insights into this coexistence. Yet, these data remain underexploited, due to the challenges derived from interpreting complex mixed taphonomic processes. The BITES project aims to reconstruct Neanderthal-carnivore interactions using targeted quantitative methodologies, which are tailored to detect patterns previously unattainable with traditional approaches. Employing both multivariate statistics and machine learning, I will initially accurately quantify hominin and carnivore relative activities across four Middle Paleolithic sites in Iberia set in different environments. Subsequently, reusing literature data, the project will build statistical and machine learning models to identify the main interaction type in previously studied sites, including scavenging, avoidance, and competition for prey. Lastly, the project will explore any environmental, spatial, or temporal shifts in these interactions and their potential correlation with settlement patterns and the eventual disappearance of Neanderthals. The findings derived from bridging cutting-edge methods with ancient data promise to reshape our perspective of Neanderthal ecological behaviour and adaptive strategies, introducing fresh, integrative approaches in Paleolithic research.

Keywords: zooarchaeology,taphonomy,human evolution,neanderthal behaviour,hominin carnivore interactions,quantitative analysis,paleoecology
Electroluminescent cooler prototype (e-COOL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Finland
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-09-01
End date: 2024-02-29
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Refrigeration is necessary in an ever increasing number of technical applications with significant societal importance. The presently available solutions, however, have several shortcomings especially in applications requiring extremely compact cooling with access to cryogenic temperatures. This project aims to provide the commercial incentive and a proof of concept for an optical cooler based on the thermodynamics of electroluminescence. The targeted cooling system would allow a robust and compact cooling method that would primarily target cooling applications at the 50-200 K temperature range that are presently largely inaccessible without using mechanical solutions. Through this project we would learn more about the validity of electroluminescent cooling (ELC) in practical applications as well as its most likely pathways towards commercialization.
In-Touch: Implementation of a person-centered palliative care iNtervention To imprOve comfort, QUality of Life and social engagement of people with advanced dementia in Care Homes (In-Touch)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Ireland,Belgium,United Kingdom,Czechia,Italy,Netherlands,Canada,Poland,Portugal,Slovenia
Call: Novel approaches for palliative and end-of-life care for non-cancer patients (HORIZON-HLTH-2023-DISEASE-03, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 5779835.0
EU funding (EUR): 5723637.0
Participants: 13
Project status: SIGNED

Challenge. Caring for the increasing numbers of people across Europe with advanced dementia and palliative care needs who live in care homes is difficult and demanding. People with advanced dementia can be immobile, non-verbal and unable to take part in day-to-day activities. They can be unsettled or agitated, with low quality-of-life and elevated levels of discomfort. Family members can find it difficult to connect meaningfully with their relative and are anxious about the future. Care staff can struggle to provide care other than for basic needs such as feeding, toileting and skin care. Solution. An ethically sound solution which advances beyond the science, providing both care ‘in-the moment’ (using Namaste Care) and planning for future care needs (using the Family Carer Decision Support ‘Comfort Care’ approach). We call this the In-Touch intervention. Plan. To deliver a cross-country cluster randomised controlled trial of the In-Touch intervention in 56 nursing care homes across 7 countries to determine its effect on comfort, social engagement and quality of life. This is supported by 9 work packages ensuring that: the intervention is robustly planned and contextualised for different country settings; there is understanding of how it is delivered, and what people experience and ethically value about the intervention; the cost-effectiveness is understood; we have effective plans to transfer knowledge about this intervention if it is successful. Impact. This intervention could herald a major change in the way that care for people with advanced dementia, in the palliative phase of their illness, is provided across Europe. People with advanced dementia should have better quality of life as they approach death, improved engagement and reduced social isolation. Care staff will have an ethically sound and evidence-based intervention that is cost-effective to implement, with family members more involved in, and knowledgeable about, comfort care and future care plans.

Keywords: palliative care,advanced dementia,family caregivers,care homes,social inclusion,quality of life,comfort,rct,symptom management
Facilitating Innovations for Resilient Livestock Farming Systems (Re-Livestock)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Research and Innovation actions
Countries involved: Spain,Netherlands,Italy,Portugal,Germany,Poland,Austria,Switzerland,Australia,United Kingdom,Sweden,Denmark,Ireland
Call: Resilient livestock farming systems under climate change (HORIZON-CL6-2021-CLIMATE-01, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 9560958.75
EU funding (EUR): 9560133.75
Participants: 37
Project status: SIGNED

The overall objective of Re-Livestock is to evaluate and mobilize the adoption of innovative practices applied cross-scale (animal, herd, farm, sector and region) to reduce GHG emissions from livestock farming systems and increase their capacity to dealing with potential climate change impacts. To reach our aim, Re-Livestock have brought together the excellence scientific expertise in Europe and Australia and across disciplines, including co-innovation, animal feeding, breeding, welfare, farm management, environmental and socio-economic assessment and policy analysis, to develop novel and scientifically supported integrated approaches specific for different dairy, beef and pig systems and geographic regions in the context of climate change. Strong collaboration with industry stakeholders to identify the innovations and to co-design the validation will ensure relevance and maximise the adoption of best practices. National groups of farmers (case studies) and ‘stakeholder forums’ together with a ‘European multi-actor platform’ will allow for an engaged co-design of transition pathways whilst ‘learning from innovation networks’ will allow for the testing and sharing of latest innovative solutions. A ‘community of practice’ will extend the multi-actor approach to a broad range of stakeholders.

Keywords: livestock,mitigation,adaptation,climate change,co innovation,adoption,farming systems,resilience,circularity
IntraVenous Immune Boost (IVI-Boost)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,Belgium
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-05-01
End date: 2026-02-28
Duration (months): 22.0
Total project cost (EUR): 6910955.5
EU funding (EUR): 2499999.0
Participants: 2
Project status: SIGNED

What if we could finally treat metastatic patients and uncurable cancers like sarcomas ? HEPHAISTOS-Pharma developed ONCO-Boost, the first-in-class intravenous TLR4 immunostimulant that will be a game changer in immunotherapy. This innovation was discovered after 40 years of research from a woman entrepreneur who developed a mature, scalable, disruptive and eco-friendly platform. ONCO-Boost can cure hard to treat cancers as a stand-alone treatment but can also increase the efficacy of existing treatments. Our cure is injected intravenously and this changes everything, we can offer therapeutic options for patients with metastatic cancers and hardly accessible tumors. As such, ONCO-Boost can cure 10x more patients than competitors, all limited to intratumoral injection. HEPHAISTOS' ambition is to become the European leader in immunostimulants, with a platform able to supply the market with large quantities of drugs, able to save millions of patients each year.

Keywords: tlr4,immunostimulant,immuno oncology,immunotherapy,osteosarcoma
Copper(II) Induced Oxidation of Enolates via Visible Light Induced Homolysis (CuII-VLIH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

CuII-VLIH is envisaged and designed to develop novel synthetic strategies to access a wide variety of bioactive cyclic and acyclic 1,4-dicarbonyl organic compounds via Cu(II) mediated oxidation of enolates using visible light induced homolysis (VLIH). Considering the earth abundance and low cost, Cu(II)-based complexes are recently being utilized as efficient photocatalysts and as low-cost alternative to the Ru or Ir-based complexes. A range of Cu(II)-complexes will be screened in the proposed work for optimizing the efficiency of the aforementioned enolate oxidation processes via photoredox catalysis. The most effective catalyst will oxidatively activate the substrates and the reactions will proceed through the generation of photoinduced reactive species (enol radicals) that can be productively exploited for the synthesis of a range of biologically significant dicarbonyl compounds by successive reaction with an alkene acceptor followed by quenching with molecular oxygen. CuII-VLIH will address the long-standing problem of finding an appropriate classical activation mode for different varieties of enolizable ketones by providing a remarkable activation mode through the formation of enol radical intermediates. CuII-VLIH also aims to bridge the gap between the fields of medicine and energy by enabling facile and highly selective synthesis of a wide array of high value heterocyclic moieties by utilizing copper complexes as environmentally benign photoredox catalysts and visible light as a sustainable source of energy. The successful photoactivation of enolates and subsequent combination of enol radical with suitable alkene acceptors in the presence of molecular oxygen would also allow synthesis of various carbocyclic and heterocyclic natural products such as convulatamydine A and pharmaceutically relevant compounds like AG-041R, serotonin 5HT1A receptor antagonist via late-stage modifications.

Keywords: visible light,copper,photoredox catalysis,oxidation,enolates,1,4 dicarbonyls,oxindoles
Experimental investigation of CO2 solubility trapping in heterogeneous 3D porous media (ExpeCO2SolTrap)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 3
Project status: CLOSED

Atmospheric CO2 contributes to 2/3 of the Earth’s global warming by greenhouse effect. Storing CO2 in deep geological formations is the main mitigation measure currently available. ExpeCO2SolTrap addresses solubility trapping (ST), a trapping mechanism of CO2 in dissolved form within the resident brine of the subsurface porous medium, which allows storing CO2 perennially by gravity. ST has been studied extensively in the last 10 years. But numerical studies cannot account for the pore scale heterogeneity of the flow, while most experiments cannot provide a full measurement of the system’ evolution (in particular its dissolution flux). Recent ground-breaking experiments by the host group and secondmend group of ExpeCO2SolTrap have shown that the growth of the instability is orders of magnitude faster than that predicted by a Darcy scale numerical simulation of the experimental process, due to coupling beween the gravitatitional instability and the heterogeneity of pore scale flow. This effect has been hitherto ignored in the literature. Furthermore, the impact of Darcy scale heterogeneity has hardly been studied, in particular not experimentally. ExpeCO2SolTrap proposes to (i) extend the experiments developed in the host group and secondment group to allow for pore scale measurement of fluid velocities three-dimensional (3D) granular porous media, in order to fully understand the aforementioned coupling, and (ii) to study the impact of Darcy scale (e.g., permeability/porosity) heterogeneity of the medium experimentally in granular porous media as well as in 3D-printed porous media of controlled heterogeneity. Two experiments, both relying on refractive index matching of the flowing liquid to the solid phase, but using respectively analogue fluids and dissolved CO2, will be used in parallel. Pore scale concentration fields will be measured by laser-induced fluorescence and scanning by laser sheets, while fluid velocities will be measured by stereo-PIV.

Keywords: carbon dioxide sequestration,gravitational instabilities,solubility trapping,rayleigh taylor instabilities,convective transport
Sustainable preservation of underwater archaeological sites: A novel approach to cultural heritage management (ENDURE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Denmark
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2496306.0
EU funding (EUR): 2496306.0
Participants: 1
Project status: SIGNED

Cultural heritage is the legacy of tangible, intangible and natural heritage assets of a society that is inherited from past generations. Preserving the remains of the past for the benefit of future generations is common in international heritage policy. Current management practice advocates preserving underwater cultural heritage (UCH) where it lies on the seabed, in situ. However, this practice is questioned due to a lack of understanding of the entangled threats posed by multiple natural and anthropogenic drivers. In a rapidly changing ocean environment and increasing human exploitation of the marine environment, it is necessary to develop new concepts for assessing and preserving this resource. With over 3,000,000 shipwrecks and thousands of submerged prehistoric sites lying on the floors of the world’s oceans, ENDURE aims to disentangle both natural and anthropogenic decay processes, determine their cumulative and interactive effects on UCH and proposes a novel conceptual framework to preserve this heritage based on site entropy. This will be achieved by: 1) Detect, visualise and interpret the products of natural and anthropogenic decay of shipwrecks and submerged prehistoric sites using marine remote sensing techniques integrated with natural and anthropogenic variables in a GIS platform; 2) Determine key natural processes and rates of decay of archaeological materials in situ and in the laboratory; 3) Remotely identify and rank simultaneous decay processes, including increasing threats to hidden and largely inaccessible heritage sites using ecosystem modelling, and 4) Propose novel intervention methods to mitigate threats to UCH and where not possible, strategies for curated decay. Ultimately, ENDURE’s holistic structured framework can be synergistically integrated and implemented by stakeholders and marine practitioners for a sustainable preservation of the marine environment and the world’s underwater cultural legacy for future generations.

Keywords: underwater cultural heritage,sustainable management,ecosystem modelling,remote sensing,deterioration and decay of cultural sites,mitigation and preservation practices,natural heritage