Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A GRID-BASED e-INFRASTRUCTURE FOR DATA ARCHIVING/COMMUNICATION AND COMPUTATIONALLY INTENSIVE APPLICATIONS IN THE MEDICAL SCIENCES (NEUGRID)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to existing research infrastructures
Action type: Combination of CP & CSA
Countries involved: Italy,United Kingdom,Netherlands,Sweden,France,Switzerland,Spain,Spain
Call:  (FP7-INFRASTRUCTURES-2007-1, 2007)
Start date: 2008-02-01
End date: 2011-01-31
Duration (months): 36.0
Total project cost (EUR): 3305014.0
EU funding (EUR): 2800000.0
Participants: 9
Project status: CLOSED

Aim of this proposal is to deploy e-Infrastructures (EC-funded MammoGrid and AddNeuroMed’s NeuBase) to enable the European neuroscience community to carry out research required for the pressing study of degenerative brain diseases to build a new user-friendly Grid-based research e-Infrastructure (neuGRID), where the collection/archiving of large amounts of imaging data is paired with computationally intensive data analyses. This proposal will initially provide neuroscientists with the capability to identify neurodegenerative disease markers through the analysis of 3D magnetic resonance brain images via the provision of sets of distributed medical and Grid services and later to provide a general, expandable infrastructure of services for other medical applications. neuGRID will be compliant with acknowledged EU and international standards regarding data collection, data management, and Grid construction. Of the two deployed infrastructure, MammoGrid will provide knowledge related to the middleware and upperware that will allow applications to talk to the Grid, and AddNeuroMed that related to the collection/archiving/retrieval of multicentre clinical data, biomedical images and computerized image analysis. Key research challenges will be: the gridification of algorithm pipelines for brain image analysis, the development of a mid-layer of services between user-facing and grid-facing services to make the infrastructure expandable to a number of algorithm pipelines, and testing and validation of the prototype infrastructure. neuGRID aims to become the "Google for Brain Imaging", providing a centrally-managed, easy-to-use set of tools with which scientists can perform analyses and collaborate.

Keywords: e-infrastructure,grid,grid computing,neuroscience,neuroimaging,computational neuroscience,alzheimer's disease,image repository
International network for capacity building for the control of emerging viral vector borne zoonotic diseases (ARBO-ZOONET)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Sustainable production and management of biological resources from land, forest, and aquatic environment
Action type: Coordination and support actions
Countries involved: France,Germany,United Kingdom,Sweden,Italy,Slovenia,South Africa,China,Iran, Islamic Republic of,Germany,Netherlands,Senegal,Spain,Greece,Italy,Spain,United Kingdom,Türkiye,Italy,Germany,Belgium,Portugal
Call:  (FP7-KBBE-2007-1, 2007)
Start date: 2008-05-01
End date: 2012-10-31
Duration (months): 54.0
Total project cost (EUR): 1115163.2
EU funding (EUR): 998470.0
Participants: 26
Project status: CLOSED

West Nile Fever (WNF), Rift Valley Fever (RVF) and Crimean-Congo Haemorrhagic Fever (CCHF) are arthropod-borne diseases of different domestic and wild animals and can also affect humans, posing a great threat to public health because of their epidemic and zoonotic potential. Their geographical distribution has expanded in recent decades. WNF outbreaks have already occurred in Europe, CCHF is endemic in many countries including Europe. In 2000, RVF, was reported the first time outside of the African continent, cases being confirmed in Saudi Arabia and Yemen. This virgin-soil epidemic raises the threat of expansion into other parts of Asia and Europe. There is a general public concern regarding emerging zoonotic diseases which has gained new relevance in the light of global warming. This is especially true regarding the spread of vector-borne diseases such as CCHF, RVF and WNF. It is imperative to work out integrated control measures which include vector control, vaccination programmes, improved therapy strategies, diagnostic tools and surveillance, public awareness, capacity building and improvement of infrastructure in endemic regions. The anticipated project will address these areas specifically aiming at: 1) creating common knowledge on the diseases, sharing and exchanging data, expertise, experiences and scientific information; 2) maintaining and expanding surveillance systems, monitoring disease occurrence, and vaccine use; 3) introducing, distributing and harmonizing disease detection and control tools; 4) disseminating knowledge and training staff of relevant third countries; 5) interlinking different scientific disciplines which look at the problem from differrent angles. A coordinated research programme including key laboratories in Europe and neighbouring countries can address scientific questions of joint interest enabling the development of effective control measures, aimed at improving the EU's response to outbreaks of diseases.

Keywords: cchf,rvf,wnf,integrated control,arbovirus,haemorrhagic fever,encephalitis,mosquito,tick
Conflicting demands of land use, soil biodiversity and the sustainable delivery of ecosystem goods and services in Europe (SOILSERVICE)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Sustainable management of resources
Action type: Collaborative project
Countries involved: Sweden,Netherlands,Germany,Netherlands,Finland,Denmark,United Kingdom,United Kingdom,Greece,Czechia,Sweden
Call:  (FP7-ENV-2007-1, 2007)
Start date: 2008-09-01
End date: 2012-02-29
Duration (months): 42.0
Total project cost (EUR): 4583766.0
EU funding (EUR): 3475774.0
Participants: 11
Project status: CLOSED

European soil biodiversity is pivotal for delivering food, fiber and biofuels and carbon storage. However, the demand is greater than the amount of soil available, as production of biofuels competes with areas for food production and nature. Moreover, intensified land use reduces soil biodiversity and the resulting ecosystem services. SOILSERVICE will value soil biodiversity through the impact on ecosystem services and propose how these values can be granted through payments. SOILSERVICE will combine interdisciplinary empirical studies and soil biodiversity surveys to construct soil food web models and determine effects of changing soil biodiversity on stability and resilience of carbon, nitrogen and phosphorus cycling, as well as assess consequences for outbreaks of pests or invasive species. SOILSERVICE will link ecological and economic models to develop a system for valuing soil biodiversity in relation to ecosystem services. Objectives: • Develop methods to value soil ecosystem services during different pressure of land use and changes in soil biodiversity. • Field and modelling studies will determine to what spatial and temporal scales soil biodiversity and soil ecosystem services are vulnerable to disturbance. • Detecting processes that indicate when ecosystems are approaching the limits of their natural functioning or productive capacity. • Establishing methods to determine and predict sustainability of ecosystem services at different types of land use • Building scenarios to identify economical and social drivers of how land use such as biofuel production and land abandonment can influence soil biodiversity and ecosystem services over European scale. • Interacting with EU policies and strategies with results on which services are at threat and mitigating changes in soil biodiversity to achieve a sustainable use of soils. Our results contribute to a European knowledge-based competitive economy and to a future EU directive on soils.

Keywords: soil biodiversity,ecosystem services,biofuel,agriculture,sustainable soils,soil organic matter
Aerodynamic loads estimation at extremes of the flight envelope (ALEF)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Aeronautics and air transport
Action type: Collaborative project
Countries involved: France,Spain,Germany,Italy,Spain,Italy,France,Germany,Germany,Germany,Sweden,Netherlands,France,Switzerland,Sweden,Italy
Call:  (FP7-AAT-2007-RTD-1, 2007)
Start date: 2009-05-01
End date: 2012-04-30
Duration (months): 36.0
Total project cost (EUR): 5523439.2
EU funding (EUR): 3390000.0
Participants: 20
Project status: CLOSED

ALEF's objective is to enable the European aeronautical industry to create complete aerodynamic models of their aircraft based on numerical simulation approaches within the respective development processes. I.e. ALEF will kick-off a paradigm shift from greater confidence in experimentally measured loads data to greater confidence in computational results. Beyond the scope of ALEF this paradigm shift will essentially influence the overall aerodynamic development process. The objective has three aspects: 1. Comprehensiveness refers to the ability to predict aerodynamic forces, moments and their derivatives in time for any point of the flight regime. It is addressed by two complementary approaches: A high fidelity CFD based approach serves short-term impact. Long-term improvements are delivered by incorporation of simulation tools of different fidelity. 2. Quality refers to the accuracy and physical correctness of each flow simulation result used for aero data prediction as well as to a high coherence of aero data integrated over the complete flight envelope from tools of varying fidelity. It is improved by considering the impact of physical modelling as well as novel quality control means to achieve a highly coherent data space representation. 3. Efficiency refers to the necessity to compute the entire aero data space within time frames dictated by industrial design processes at given costs. It is tackled by means of surrogate models for both steady and unsteady flows. Also planning techniques for efficient simulation campaigns are addressed. The ultimate scope of using simulation tools in aero data generation is to cover all flight conditions and configurations by means of a numerical toolbox. This would ensure an up-to-date and fast estimation of most recent statuses of aircraft with every data consistent. ALEF will essentially contribute to a 70% wind tunnel testing cost reduction by 2020, which will cut the aerodynamic development effort by about 40%.

Keywords: aerodynamic loads,flight envelope,surrogate models,computational fluid dynamics
European Multidisciplinary Seafloor Observation (EMSO)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to new research infrastructures
Action type: Combination of CP & CSA
Countries involved: Italy,France,Germany,Ireland,Spain,Sweden,Greece,United Kingdom,Norway,Portugal,Türkiye,Netherlands
Call:  (FP7-INFRASTRUCTURES-2007-1, 2007)
Start date: 2008-04-01
End date: 2012-09-30
Duration (months): 54.0
Total project cost (EUR): 5423781.7
EU funding (EUR): 3900000.0
Participants: 13
Project status: CLOSED

The European Multidisciplinary Seafloor Observation - Preparatory Phase (EMSO-PP) is a 4-year project with the main objective of establishing the legal and governance framework for EMSO, an infrastructure servicing scientists and other stakeholders in Europe and outside Europe for long-term deep water observation and investigation. The Preparatory Phase will handle all further actions towards the actual realisation of the infrastructure and its long-term management. Moreover, it will promote the catalytic process and synergic effort at EC and national levels, coordinating and harmonising all the resources made available, in link with the Network of Excellence ESONET. One peculiarity of the EMSO infrastructure, among the ones indicated within ESFRI, is that it is geographically distributed around European waters from the Arctic to the Mediterranean Sea EMSO cabled deep-sea observatories deployed on specific sites will allow – as a basic scientific objective – to make real-time long-term monitoring of environmental processes in the geosphere, biosphere and hydrosphere of European seas. The observatories will be organised in a unique management structure at European level which is part of an international endeavour in seafloor observatories. A pan-European Core Legal Entity (CLE) and several Regional Legal Entities (RLEs) will be defined and founded. The responsibilities of CLE and RLEs, with respect to their internal decision-making processes, as well as their external relations (to stakeholders, users, etc.) will be established. In the project, 9 work packages are envisaged to manage all the activities (including legal, governance, logistical, financial, strategic, and technical work). EMSO-PP will constitute a breakthrough towards a large scale European infrastructure progressing the scientific knowledge and technologies. It will providing an innovative mean for environmental monitoring and geo-hazard impact mitigation.

Keywords: seafloor multidisciplinary monitoring network
Probabilistic Long-term Assessment of New Energy Technology Scenarios (PLANETS)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Knowledge for energy policy making
Action type: Collaborative project
Countries involved: Italy,Netherlands,Germany,France,Switzerland,Sweden,Lithuania,United Kingdom,Netherlands
Call:  (FP7-ENERGY-2007-1-RTD, 2007)
Start date: 2008-01-01
End date: 2010-06-30
Duration (months): 30.0
Total project cost (EUR): 1927049.8
EU funding (EUR): 1541673.6
Participants: 9
Project status: CLOSED

The goal of PLANETS is to devise robust scenarios for the evolution of energy technologies in the next 50 years. This is achieved by means of an ensemble of quantitative and analytical tools that are designed to foresee the best technological hedging policy in response to future environmental and energy policies. Focused technological assessments will provide the necessary guidance for technology availability and competitiveness. Given the long term nature of the analysis, not to mention the many uncertainties surrounding the natural, technological and socio-economic determinants, the scenarios development will be accompanied by probabilistic and stochastic modelling analysis to quantify the most determinant sensitivities. To this purpose, a suite of state-of-the-art energy-economy-climate models will be brought together. The model portfolio spans varieties of regional coverage, technological detail and economic interrelations. Dedicated integrated assessments will explore the technological options that are most likely to play a role over the time horizon under investigation, and the critical issues that are needed for their competitive deployment. PLANETS will research the future of energy systems by examining environmental and energy policies at the European and global level in their capacity to influence the deployment of new technologies with respect to a mutually agreed Business-As-Usual scenario. This project will also analyse the linkage between European and world perspectives of energy technology futures and forecasts, in particular in terms of issues like economic competitiveness and the capacity to export clean technology adoption. Finally, PLANETS will aim to broadly disseminate EU energy technology futures, by setting up an informative scenarios website and acquainting a large number of stakeholders – from science, industry, government and so forth – with peer-reviewed publications and a final general-audience conference.

Keywords: energy technologies,long term scenarios,environmental policies,sustainability and competitiveness
Targeted DISCOvery of novel cellulases and hemicellulases and their reaction mechanisms for hydrolysis of lignocellulosic biomass (DISCO)

Framework: FP7 — Cooperation
Programme: Food, Agriculture and Fisheries, and Biotechnology
Destination: Life sciences, biotechnology and biochemistry for sustainable non-food products and processes
Action type: Collaborative project
Countries involved: Finland,Netherlands,United Kingdom,Russian Federation,Hungary,Sweden,Estonia
Call:  (FP7-KBBE-2007-1, 2007)
Start date: 2008-08-01
End date: 2012-07-31
Duration (months): 48.0
Total project cost (EUR): 4001460.0
EU funding (EUR): 2985845.0
Participants: 12
Project status: CLOSED

The aim of the proposed DISCO project is to develop more efficient and therefore more cost-effective cellulosic and hemicellulosic enzyme tools for the enhanced hydrolysis of pre-treated lignocellulosic biomass in simultaneous saccharification and fermentation (SSF) conditions for bioethanol production. The focus will be on enzymes having increased catalytic activity on various types of relevant European lignocellulosic biomass. In addition enzymes with lower affinity for lignin shall also be developed. Such enzymes would increase the effective amount of cellulases/ hemicellulases for cellulose hydrolysis. Furthermore the recycling of these enzymes would be applicable. The approach in this proposal is to discover the desired activities by combining classical and modern screening technologies. The enzymes will be produced in suitable host systems for industrial enzyme production. The project also focuses on elucidation of enzymatic hydrolysis mechanisms, about which there is a paucity of knowledge. The project will determine the limiting structural factors in these mechanisms by characterisation of the substrate during the course of the hydrolysis and the remaining recalcitrant residue. Synergy between different cellulase and hemicellulases components will also be addresses on the chosen lignocellulosic substrates. Furthermore, the project seeks to demonstrate the proof of concept with the cellulolytic enzymes in a pilot scale using the most relevant European feedstock pretreated wheat straw and related high-volume co-products.

Keywords: enzymes,cellulase,hemicellulase,biomass,lignocellulose,hydrolysis,screening,discovery,bioethanol,biorefinery,mechanisms
Carbohydrate Multivalent Systems as tools to study Pathogen interaction with DC-SIGN (CARMUSYS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain,Italy,France,Germany,United Kingdom,Czechia,Netherlands,France,Germany,Netherlands
Call:  (FP7-PEOPLE-2007-1-1-ITN, 2007)
Start date: 2009-01-01
End date: 2012-12-31
Duration (months): 48.0
Total project cost (EUR): 3123720.43
EU funding (EUR): 3123720.43
Participants: 13
Project status: CLOSED

The importance of glycosciences in the development of biology and medicine and the central role played by chemistry in this process have recently been pointed out by ESF. However, it appears that exposure of young scientists in their training phase to the chemical biology of carbohydrates is still lacking. This multidisciplinary project intends to approach the design and synthesis of carbohydrate multivalent systems to be used as tools to study the interaction between carbohydrates and DC-SIGN (Dendritic Cell-Specific ICAM-3 Grabbing Non-integrin), a C-type lectin implicated in the recognition of pathogens and in some of the earliest stages of the infection process. Targeting pathogens at the earliest stages of infection, before cell penetration, is of crucial importance because it can result in a significant decrease of pathogen titre in the organism and therefore will facilitate the efficiency of current therapies. The role that DC-SIGN plays in the immune response through the interaction and recognition of pathogens leads to a very complex pathway of signalling cascade that could be modulated using these carbohydrate multivalent systems as effectors. Thus the studies we propose could provide the background for the design, selection and preparation of better antiviral drugs and could afford new insights to unravel the complex mechanisms of the immune system, thus opening a strategy to develop vaccines through the modulation of dendritic cells activity. To reach these goals, a highly interdisciplinary group of scientists (synthetic chemists, computational chemists, biochemists, immunologists, etc.) has been assembled, some of whom are already collaborating on the topic. The planned flow of information between laboratories and the network-wide training activities described in this proposal will create an unrivalled environment for training of young scientists in glycosciences.

Keywords: organic chemistry,carbohydrates,biological chemistry,dc-sign,molecular recognition,multivalency,viral infection,macromolecular chemistry,natural sciences
Single Molecule Workstation (SMW)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Austria,Poland,Austria,Germany,United Kingdom,Germany,Germany
Call:  (FP7-NMP-2007-SME-1, 2007)
Start date: 2008-12-01
End date: 2011-11-30
Duration (months): 36.0
Total project cost (EUR): 3070118.53
EU funding (EUR): 2066150.0
Participants: 10
Project status: CLOSED

This proposal aims at the development and application of an innovative single molecule workstation, enabling advances in the research happening throughout Europe and the rest of the world around the investigation of living cells. By combining three most advanced microscopic techniques into a single workstation, we aim at reaching a new quality level in the study of the molecular biology of living cells. The proposed single molecule workstation will be composed of three key elements: (i) inverted light microscope (ILM); (ii) atomic force microscope (AFM); and (iii) optical tweezers (OT). A true virtue of this initiative is that by combining several ultra-sensitive microscopy techniques into a single workstation completely new horizons for molecular biology related studies are opened. The aim of this combined ILM-AFM-OT setup is to look at the surface topography using high-resolution AFM, to study the distribution of cellular molecules using high sensitive fluorescence and contrast enhanced light microscopy (ILM), and to measure molecular interaction forces with ultra-sensitive optical tweezers. As a complementary method, photo-thermal nano-spectroscopy (PTNS) will be used to investigate spectroscopic properties of cellular material with a spatial resolution down to sub-100 nm which will enable chemical analysis of sub-cellular components. The combined setup will provide a qualitatively new level in microscopic studies, giving unprecedented versatility in the detection and monitoring of cellular events with highest spatial and temporal resolution. The proposed single workstation will be used for the study of the correlation between structure and function of living cells with applications in immunology and cancer research.

Keywords: nanotechnology,afm,inverted light microscope,ilm,photo-thermal nano-spectroscopy,ptns,optical trap,advanced microscopic techniques,single molecule workstation.