Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ULTRAsensitive PLAsmonic devices for early CAncer Diagnosis (ULTRAPLACAD)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Italy,Italy,Austria,Austria,Italy,Italy,Finland,Finland,Sweden,France,France,Czechia,Netherlands,Netherlands
Call: Development of new diagnostic tools and technologies: in vitro devices, assays and platforms (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-05-01
End date: 2018-10-31
Duration (months): 42.0
Total project cost (EUR): 6026455.0
EU funding (EUR): 6026455.0
Participants: 19
Project status: CLOSED

Cancer biomarkers circulating in body fluids have been shown to reflect the pathological process and for this reason can be used for cancer diagnosis, prognosis and choice for therapeutic interventions. It is proven that their detection is a key to new minimal-invasive detection approaches. However, barriers to wide spread use of similar approaches are lack of test sensitivity, specificity and limited availability of low cost detection platforms. This project is focused at developing a compact plasmonic-based device with integrated microfluidic circuit and functionalized nanostructures for the detection of DNA, microRNA and tumor autoantibodies cancer biomarkers. The aim is to detect cancer biomarkers circulating in blood with improvement in sensitivity of factor up to 1000, reduction in cost of platform of factor ranging from 2 to 4 compared to today’s available techniques and analysis time less than 60 minutes. The proposed detection approache will provide ultrasensitive detection of biomolecular systems with no need for complex sample chemical modifications thus allowing direct and simple assays to be performed. Within the project a bimodal industrial prototype will be developed integrating novel surface plasmon resonance imaging and plasmon-enhanced fluorescence sensing technologies, respectively. Automated fabrication processes suitable for low cost mass production will be developed and applied to produce disposable integrated chips. Prototype will be specifically fabricated for early diagnosis and prognosis of colorectal cancer. The team includes partners holding cross-disciplinary competencies needed to achieve the proposed results, including two of the first five plasmon resonance groups in the world, the inventor of surface plasmon microscopy – also known as surface plasmon resonance imaging- and plasmon-enhanced fluorescence spectroscopy, and full European value chain including disposable chip and readout platforms design, development and manufacturing.

Keywords: in vitro cancer detection,nanostructures enhanced surface plasmon resonance imaging,plasmon enhanced fluorescence spectroscopy imaging,microfluidics,nanoparticles
Evolution of the Cochlea and Hearing in Odontocetes (ECHO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-02
End date: 2019-10-01
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Toothed whales (Odontoceti) are a spectacular example of evolutionary adaptation, highly specialised apex predators and a key component of modern ocean ecosystems. The key innovation that has facilitated their evolutionary success is echolocation. Research into odontocete hearing has so far been biased towards physiological experiments and auditory pathway identification; quantitative studies on the cochlea are lacking, despite its critical role in audition. I will fill this gap in knowledge of the cochlea in cetaceans by: (1) quantifying differences in the morphology of odontocete cochlea through the application of cutting-edge scanning, visualisation and quantitative analytical techniques (e.g. 3D geometric morphometrics) to gather in depth data of all features of a fully representative range of odontocete cochlea; (2) testing through statistical analysis whether these differences correlate with, or are driven by, factors such as diet, behaviour or auditory sensitivity; (3) incorporating fossil taxa to pinpoint the timing of the evolution of echolocation; and (4) identifying convergent evolution of specialised high frequency hearing in river dolphins using novel methods for testing and quantifying morphological convergence. This project will create the most comprehensive data set of odontocete inner ear models ever compiled and will mark a major advance in the understanding of cetacean sensory evolution, providing profound insights into how this enigmatic group of marine mammals came to dominate the oceans - making sense of a sixth sense. The data gathered will be made openly available to other researchers.

Keywords: odontoceti,toothed whales,cetaceans,evolution,hearing,fossils,cochlea,anatomy,morphology
Unique breakthrough ex vivo human skin model to predict efficacy and toxicity of subcutaneous drugs (HypoSkin)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Subcutaneous injection drug market is highly increasing (CAGR of 7%) and is view as a viable alternative route for parenteral drug administration because it enables at-home injection, improves quality of life and reduces health care costs. However, the absence of accurate biological model to predict the effect of drug injection in the subcutaneous tissue limits their development. That issue leads to 88% of drug attrition causing a loss of more than €1B per developed drug and a sharp decrease of patient security during clinical trials. HypoSkin is the first and unique in vitro standardized and ready-to-use testing kit containing living ex vivo human skin biopsies with subcutaneous fat, allowing pharmaceuticals to highly reliably predict local human’s response to the injection of a drug or a medical device. This disruptive innovation permits Hyposkin’s customers to save time and money (10 times faster and 5 times cheaper than animal experiment, confirmed in the on-going payed pilot test) as well as secure the development of their products before clinical trials. HypoSkin will become worldwide reference method to replace inadequate animal testing currently used today. HypoSkin model is developed by Genoskin an innovative French company, founded in 2011 as a spin-off of the French National Center for Scientific Research and the Paul Sabatier University in Toulouse. Genoskin provides other human-skin alternative models to pharmaceuticals companies all over the world leading to sales of €700K in 2017. The SME Instrument project will allow the company to improve, qualify and industrialise HypoSkin. To accomplish this goal Genoskin will complete a feasibility study to further analyse risks and cost of scale-up, the European regulatory framework and will deepen and sharpen the global subcutaneous injection market. Genoskin plans to lead the European and global alternative method market with an estimated turnover of € 34 M by 2024, and 110 new European and worldwide jobs.

Keywords: alternative method to animal testing,subcutaneous injection drug development,predictive model,preclinical trials,skin tests,hypodermis
Thawing Carbon From LAND to SEA: Microbial Degradation of Organic Matter and Response to Thawing Permafrost in the Northeast Siberian Land-Shelf System (TCFLAND2SEA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-01
End date: 2022-02-28
Duration (months): 24.0
Total project cost (EUR): 203852.16
EU funding (EUR): 203852.16
Participants: 1
Project status: CLOSED

Arctic permafrost (PF) as vulnerable carbon stock to global warming is increasingly receiving attention due to significant importance in global climate change. Immense carbon stock is held in surface soils on land, coastal Pleistocene Ice Complex Deposit and sediment of shallow subsea in Arctic. Under global warming, the emission of greenhouse gases CO2 and CH4 from PF could further intensify global warming; however, the key link between thawing PF and greenhouse gas emission -microbial degradation remains poorly understood. Microbial degradation of organic matter and its response to thawing is conducive to understanding the biogeochemical carbon cycle and even the future prediction of greenhouse gases in Arctic. To better understand microbial mediation on PF-carbon feedback to global warming, this proposal aims to quantitatively estimate the microbial activity and metabolism in different types of PF (inland, coastal Ice Complex Deposit and marine sediment of subsea PF) from the northeast Siberian via multidisciplinary techniques including microcosm incubation, lipid-based stable isotope probing, modelled metabolic flux analysis and metabolomics. This proposal will improve the understanding of microbial ecosystem in response to thawing PF and their roles in biogeochemical carbon cycle in Arctic.

Keywords: biogeochemistry,environmental microbiology,stable isotope probing,metabolic flux analysis,metabolomics,arctic permafrost
ERA NET NEURON in the area of brain-related diseases and disorders of the nervous system (NEURON Cofund)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: ERA-NET Cofund
Partnership: NEURON Cofund (ERA-NET)
Countries involved: Austria,Germany,Spain,Italy,Israel,Germany,Norway,Finland,Poland,Türkiye,Belgium,Romania,Slovakia,Latvia,France,Netherlands,Canada,Portugal,United Kingdom
Call: ERA NET Collaboration and alignment of national programmes and activities in the area of brain-related diseases and disorders of the nervous system (H2020-HCO-2015, 2015)
Start date: 2016-01-01
End date: 2022-12-31
Duration (months): 84.0
Total project cost (EUR): 20882250.0
EU funding (EUR): 6772342.5
Participants: 24
Project status: CLOSED

The ERA-NET NEURON Cofund will coordinate and align European and international research funding programmes in the area of brain-related diseases and disorders of the nervous system. Key activity is the implementation of an EC co-funded joint transnational call for research proposals. The mission of NEURON is based on the fact that disorders of the brain are the major cause for impaired quality of life, and they are a heavy burden not only for patients, their families and carers, but also a socioeconomic problem for society. By improving collaboration and by implementing a variety of additional activities (such as further joint transnational calls and support of early-career scientists) NEURON Cofund will decrease fragmentation of research programmes and improve the funding situation for neuroscience researchers thereby strengthening the search for novel therapeutic approaches to fight brain disease; NEURON Cofund will also develop and provide concrete plans for (i) expanding data sharing, (ii) promoting common data elements for the establishment of patient registries, and (iii) involving stakeholders and relevant existing initiatives such as patient organizations. The aforementioned challenges will be addressed in a network of 22 funding organizations across 14 European Member and Associated States and Third countries.

Keywords: era net,neuron,brain related diseases,disorders of the nervous system,disease related neuroscience
Connecting EURATOM National Contact Points in a pro-active network under EURATOM Programme in Horizon 2020 (NUCL-EU 2020)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Support the development of nuclear competences at Union level and socio-economic aspects
Action type: Coordination and support actions
Countries involved: Estonia,Italy,Slovakia,Greece,Poland,Czechia,Portugal
Call: Fostering the network of National Contact Points (NFRP-2014-2015, 2014)
Start date: 2015-09-01
End date: 2020-02-29
Duration (months): 54.0
Total project cost (EUR): 500000.0
EU funding (EUR): 500000.0
Participants: 8
Project status: CLOSED

NUCL-EU 2020 is a 54 months Coordination and Support Action having the specific objectives to Ensuring high quality EURATOM NCP services on Nuclear Fission and Radiation Protection in Horizon 2020 programme to applicants; Lowering entry barriers for EURATOM NCPs approaching EU Framework Programme for R&I for the first time; Consolidating the network of EURATOM NCPs. NUCL-EU 2020 will take into consideration the significant changes that Horizon 2020 has brought about the EURATOM NCP mandate. With its brand new approach to R&I Horizon 2020 demands EURATOM NCPs: a) to address their services to a wider target, b) to have specific multidisciplinary competences. NUCL-EU 2020, whose consortium is composed by experienced and less experienced EURATOM NCPs from 7 countries, will tackle these challenges building up the NCP capacity by organizing benchmarking activities to identifying and sharing good practices, at least 7 interactive and at least 8 virtual training sessions and 7 twinning schemes (supporting at least 20 NCPs). The dialogue with participants will benefit of at least 2 enhanced cross-border brokerage events and 9 training sessions for stakeholders (2 per year). The project will also take special care of outreaching activities by extending the collaboration with other NCP thematic networks, working on partner search and cooperating on international relevant activities. Finally, communication within and outside the network and the dissemination of results will be ensured through the website, the development of promotion/ information materials, the participation at major events and PR activities and an e-mail alert service/newsletter. Throughout the project special attention will be paid to the diversity of stakeholders in the Nuclear Fission and Radiation Protection sectors, the gender dimension, as well as to establish links with other EU relevant initiatives, programmes and policies.

Keywords: network ncp,training,twinning,brokerage event,sharing best practices
Advanced nonlinear wave analysis for complex experimental data (NWACOMPLEX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-01
End date: 2024-02-29
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

The proposed research program entitled NWACOMPLEX aims at pioneering studies of nonlinear wave processes in optics and hydrodynamics implementing by young talented theoretical researcher Dr. A Gelash in exceptional collaboration with top-level experimental teams of the EU Host Université de Bourgogne and partners organizations. The transfer of the Fellow knowledge to experimental teams will make his theoretical and numerical developments widely used in practice. The project will strongly enhance the expertise and professionalism of the Dr. Gelash by high-quality trainings, new contacts and collaborations leading to a cascading effect on his career development. The Fellow being experienced inverse scattering transform technique, physics of nonlinear coherent structures and various computational methods proposes novel theoretical approaches and numerical tools for advanced analysis of modern experiments on generation, detection and nonlinear propagation of light in optical systems and waves on the surface of water. The innovative idea of the project is to reveal the nature of complex nonlinear phenomena using inverse scattering transform theory employing the most recent numerical advancements. The project will benefit the nonlinear science by fundamental studies of novel mechanisms of coherent structures interactions, statistic of nonlinear waves, dense soliton and breather gases. The Fellow will present theoretical predictions on nonlinear wave dynamics and statistic which will be verified by experimental groups of the host and partner organizations. The developed numerical tools will allow to generate various nonlinear light and water surface waves patterns for experiments on their propagation, as well as provide the opportunity to reliably analyse complex experimental data revealing coherent structures and their parameters.

Keywords: soliton,inverse scattering transform,breather,rogue waves,nonlinear waves,integrable systems,nonlinear fourier transform,soliton gas,optical fibre,surface waves,modulation instability
Enthusiasm, Passion, Inspiration, Challenge (EPIC) – join us during the Researchers’ Night and see for yourself how by connecting science and passion one can make a difference! (EPICNIGHT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Poland
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-05-01
End date: 2015-12-31
Duration (months): 20.0
Total project cost (EUR): 139825.0
EU funding (EUR): 132775.0
Participants: 6
Project status: CLOSED

Researchers’ Night again in Poznan! EPICNight! Enthusiasm, Passion, Inspiration, Challenge– join us during the Researchers’ Night and see for yourself how by connecting science and passion one can make a difference! Come and uncover the secrets of scientists and researchers! Open the doors to your good neighbours – researchers! Measure immeasurable and see invisible! Become a researcher for one night and construct DNA helix, have a ride in 3D helmet, design your own clothes or learn the secrets of Eco-robots! Come and sing karaoke songs with researchers and at the end dress up like a famous scientist and dance with us cha-cha or jive. Feel like doing some sport? These and many other attractions are waiting for you to reveal your passion for science and convince you that researchers are just ordinary people with an extraordinary job and various hobbies! EPICNIGHT is a continuation of the Researchers’ Night projects of the past seven years, which were highly successful gathering last year app. 57 000 people willing to meet researchers face to face and to learn new things about their work and personal lives. The project, promoting an image of researchers, builds on last years’ experiences and aims at enhancing further public recognition of researchers and their work by bringing them closer to the public, underlying their important contribution to the daily life and well-being of the European citizens. Activities organised during the Night on 26 September 2014 and 26 September 2015 will be focused on public at large and will have even more hassle-free and festive character, being a valid alternative to "traditional Friday night activities" while allowing learning more about researchers and research. Those activities will offer a direct contact between researchers and public, combine fun and education elements (edutainment), ensure linking together Nights organised in different cities in Poland and ensure an active and direct involvement of the visitors in activities.

Keywords: epicnight,researchers,poland,poznan,edutainment
NorrDigi revolutionary Energy Saver (Norrdigi)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-11-01
End date: 2021-03-31
Duration (months): 29.0
Total project cost (EUR): 3133625.0
EU funding (EUR): 2193537.0
Participants: 1
Project status: CLOSED

Norrhydro Oy is a Finnish hydraulic cylinder manufacturer. Since 2007, Norrhydro has developed a technology, NorrDigiTM, that has the ability to regenerate, store and share energy by the functions on mobile equipment, such as excavators, the largest market for cylinders. The economic effect of NorrDigiTM is very significant. It requires less space, is cost neutral and has proven 45-60% fuel efficiency improvement and 5-12% productivity gains in side-by-side tests with a standard excavator. NorrDigiTM is a modular control system made of highly engineered hydraulic cylinders, control valves, sensors and electronics in an integrated control package and is patented in all major countries. The initial target market is crawler excavators and large material handling equipment. The current addressable market size is 4,0 billion euros yearly. The first goal is a 5,6% market share by 2025, which means total sales will grow from 19 to 260 million euros in that period. The next target is 15% market share by 2028, which coupled with growth in adjacent markets will amount to over 800 million in annual sales. The imminent market launch is based on finalizing the product designs, testing, production investments and increased marketing. The solution is scalable, and Norrhydro performs an internal investment and LEAN improvement program to meet the increased volume demands. The other main components are modular and come from suppliers who have ample capacity. The direct effect on employment goes from 126 people in 2017 to 700 people by 2025. The SMEI-funding will assist in speeding up the launch, reduce risks, and improve the economics and the environment due to the drastically reduced fuel consumption (emissions). The funds will help securing additional financing which is planned as an IPO in 2020. The team leading the effort consists of dedicated, motivated and highly experienced professionals with long international track records of successful product and technology launches.