Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Multifunctional Immunocompatible NanoTheranostics to modulate tumor microenvironment and improve treatment monitoring: A double blow to pancreatic cancer (MINT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

Different nanomaterials were developed so far in particular against cancer, paid very little attention to their potential immunogenicity, to their final destiny, as well as to the importance of zero-delivery in unwanted places. Thus, there is still a huge disproportion between the present nanomedicine tools and the clinical requirements. The ambitious purpose of the MINT project is to develop immunocompatible tumor targeted zinc oxide nanocrystals (ZnO-NCs) coated by extracellular vesicles (EVs) with enhanced drug delivery capabilities to cancer cells, by disturbing the supportive tumor microenvironment of pancreatic cancer, one of the most lethal human malignancies. Moreover, ZnO-NCs is doped with transition metal elements to be probed for treatment monitoring. In recent years while several therapeutic advances were implemented in many cancer types, the scenario of pancreatic cancer remains unchanged. The main factor behind the limited efficacy of chemotherapeutics in pancreatic cancer is its complex microenvironment. We propose to deliver Hedgehog pathway inhibitor & vascular endothelial growth factor receptor kinase inhibitor simultaneously through the multifunctional EV-coated doped ZnO-NCs to deplete tumor stroma, normalize tumor vascularity and improve pancreatic cancer therapeutic index. The proposed Fellowship will enable a highly interdisciplinary collaboration between the Researcher, experienced in targeted therapy & pancreatic cancer biology, and the supervisor, pioneer in designing nanotheranostics. These working conditions will effectively promote the Researcher’s professional development, providing her with excellent new expertise in nanotheranostics and fundamental leadership skills, significantly widening her career perspectives. The project outcomes will be of tremendous benefit to the European biomedical sectors, bridge the current gap between the conventional therapies and the Frontier research in the field of cancer nanomedicine.

Keywords: doped zinc oxide nanocrystals,extracellular vesicle,targeted peptide ligand,tumor microenvironment,pancreatic cancer
Feasibility Study of the induction WELding, FIbre placement and shaping of Thermoplastic composites (WEL-FIT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

BERCELLA, Italian SME with established expertise in composites for advanced applications, has identified in the induction heating a breakthrough enabling technology to welding, shaping and fibre placement of composites coupled with Non Destructive Inspection. Innovative ranges of thermoplastic reinforced carbon fibre composites will be the subject of the project, unlocking new products, and revolutionising the sector. The process is established through cooperation with the research centre CETMA, granting to BERCELLA the access to the relevant know-how in the field of induction welding, developed through years of research and laboratory practice, and protected by patents. The objectives: Technological Feasibility, Market Assessment, Business Models and Plans, are addressed through a structured approach. Barriers to the implementation will be identified and overcome, permitting to identify a complete roadmap towards the industrial shop-floor and the market approach. Innovative range of products can be manufactured thanks to the innovative process, control and adaptation of the induction equipment to a range of materials that can be extended via a continuous process of industrialization, stimulated by the quality and competitiveness of the results. The basis for a successful Phase 2 project are set in accordance to the results of the present Feasibility Study, for the industrial and market acceptance of induction as a one-stop process for sustainable, automated composites manufacturing.

Keywords: composite materials,induction processing,industrialization,process upscale
Clinical validation of a continuous flow peritoneal dialysis system, with dialysate regeneration (CORDIAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Netherlands,Netherlands,United Kingdom
Call: New interventions for Non-Communicable Diseases (H2020-SC1-2020-Two-Stage-RTD, 2020)
Start date: 2021-07-01
End date: 2024-06-30
Duration (months): 36.0
Total project cost (EUR): 3482224.82
EU funding (EUR): 3482224.8200000003
Participants: 6
Project status: SIGNED

Goal is the clinical validation of a new peritoneal dialysis (PD) system called CORDIAL. Instead of a stagnant filling as in traditional PD CORDIAL continuously circulates and regenerates dialysate in the peritoneal cavity. Hereby, a significant improvement in blood purification (2-3x) can be achieved in comparison to traditional PD. For the regeneration, a sorbent unit is used to remove toxins from the peritoneal dialysate by adsorption. The sorbent system also facilitates slow release of glucose needed for osmotic removal of excess fluid (i.e. ultrafiltration). Very high glucose concentrations, as used in traditional PD and harmful to the peritoneal membrane, are no longer required, which helps to preserve the membrane function. CORDIAL is an easy to use, portable/wearable machine that allows renal patients to dialyze conveniently at home or at work, independently from a fixed water supply, up to 24 h/day. With the improved clearance and low glucose load, CORDIAL eliminates current drawbacks of PD (low efficacy, high glucose concentrations leading to damage to the peritoneal membrane), benefiting the overall health condition and quality of life (fitness, lower pill burden). In order to demonstrate clinical efficacy and safety of the system an early feasibility first-in-human (FIH) trial and a crossover feasibility trial will be performed in PD patients. The FIH study will involve a group of 12 stable PD patients in an hospital setting for 5 consecutive days. Upon successful functionality and safety analysis of the FIH trial, the clinical validation is continued in a crossover study to test the hypotheses that the system (1) improves blood purification, (2) results in adequate ultrafiltration at low glucose concentrations and (3) does not show important safety/ biocompatibility problems. Hereto 30 stable PD patients will be randomized to receive at home either CORDIAL treatment in the first 2 months and traditional PD in the month 3 and 4 or vice versa.

Keywords: continuous regeneration,peritoneal dialysis,personalised dialysate,home use,portable,kidney failure
Dynamic synthetic molecular duplexes (DyNAmics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Precise control of macroscopic properties at molecular level is one of the biggest challenges of modern science. Nature accomplishes this by adding information to matter, and organizes chemical system of nonliving components into living, biological systems. Achieving a deep knowledge on the appropriate manipulation of the intermolecular non-covalent interactions, will allow chemistry to be not only the science of the structure and transformation of matter, but also an information science, involving the storage of information at the molecular level. Inspired by the most fascinating nature’s information system, the DNA, “DyNAmics” will perform a modular and highly flexible synthesis of novel information carrying monomers, able to self-organize in duplex structure, through both covalent and non-covalent bonds formation. The reliability, robustness and the dynamic formation of H-bond based duplex, together with the template ability in a dynamic combinatorial system, will be deeply investigated. By quantitative assessment of multivalent recognition of complementary sequences and imperfections in the duplex formation of non-complementary and defective sequences, valuable information on the structural features and fidelity of supramolecular assembly formation of various sequences will be obtained. Reliable formation of dynamic synthetic duplexes would allow precise control over supramolecular interactions and will lay the foundation for formation of smart advanced materials with unprecedented properties, such as innovative data storage materials and new Constitutional Dynamic Materials. Furthermore this will be crucial for the development of efficient template directed synthesis for information encoding molecules, and it will provide information to answer to important questions regarding the formation of duplex encoding information, in a enzyme free system, such as the prebiotic word.

Keywords: duplex,dynamic combinatorial chemistry,molecular recognition,self assembly
Functional Biology of Hepatic CD8+ T cells (FATE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-07-01
End date: 2023-06-30
Duration (months): 72.0
Total project cost (EUR): 2390000.0
EU funding (EUR): 2390000.0
Participants: 1
Project status: SIGNED

CD8+ T cells have a key role in eliminating intracellular pathogens and tumors that affect the liver. The protective capacity of these cells relies on their ability to migrate to and traffic within the liver, recognize pathogen- or tumor-derived antigens, get activated and deploy effector functions. While some of the rules that characterize CD8+ T cell behavior in the infected and cancerous liver have been characterized at the population level, we have only limited knowledge of the precise dynamics of intrahepatic CD8+ T cell conduct at the single-cell level. In preliminary data for this project we have developed several advanced imaging techniques that allow us to dissect the interactive behavior of CD8+ T cells within the mouse liver at an unprecedented level of spatial and temporal resolution. We predict that this approach, combined with unique models of hepatitis B virus pathogenesis and a new model of hepatocellular carcinoma created ad hoc for this proposal, will generate novel mechanistic insights into the spatiotemporal determinants that govern the capacity of CD8+ T cells to home and function in the virus- or tumor-bearing liver. Specifically, we plan to pursue two main goals: 1) To assess how the anatomical, hemodynamic and environmental cues that characterize hepatocellular carcinomas shape CD8+ T cell behavior and function; 2) To characterize intrahepatic T cell priming events that induce functionally defective T cell responses. Results emerging from these studies will advance our knowledge on how adaptive immunity mediates pathogen clearance and tumor elimination. This new knowledge may lead to improved vaccination and treatment strategies for immunotherapy of infectious diseases and cancer.

Keywords: cd8 t cells,intravital imaging,dynamics of immune responses,liver,hepatitis b virus,hepatocellular carcinoma,immunopathology
Integrating Platforms for the European Research Infrastructure ON Heritage Science (IPERION HS)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Italy,Italy,Spain,Italy,Germany,Germany,Spain,Italy,Israel,Cyprus,Malta,Norway,Hungary,Poland,Poland,Poland,Slovenia,Sweden,Sweden,Sweden,Romania,Sweden,Belgium,Greece,Greece,Hungary,Romania,France,France,France,France,Czechia,Czechia,Netherlands,United States,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom,Portugal,Brazil,Mexico,United Kingdom,United Kingdom,Portugal
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2019-1, 2019)
Start date: 2020-04-01
End date: 2024-03-31
Duration (months): 48.0
Total project cost (EUR): 6516247.93
EU funding (EUR): 6162711.12
Participants: 68
Project status: SIGNED

The IPERION HS proposal aims at establishing and operating an Integrating Activity for a distributed pan-European research infrastructure, opening key national research facilities of recognised excellence in heritage science. Heritage science is a young and cross-cutting scientific domain embracing a wide range of research disciplines enabling deeper understanding of the past and improved care for the future of heritage. Since 2016, heritage science is included in the ESFRI Roadmap as one of the strategic areas in the domain of Social Sciences and Humanities, where it is represented by the ESFRI Project E-RIHS (European Research Infrastructure for Heritage Science). IPERION HS will provide to the advanced community of heritage science - built and reinforced with the support of four EU projects spanning across four Framework Programmes, approaching 20 years of constant service to the heritage domain - a further level of pan-European integration, in view of the establishment of E-RIHS. IPERION HS is a further step towards a unified scientific approach to the most advanced European instruments for the analysis, interpretation, preservation, documentation and management of heritage objects in the fields of art history, conservation, archaeology and palaeontology. IPERION HS core activity will be offering Trans-National Access to a wide range of high-level scientific instruments, methodologies, data and tools for advancing knowledge and innovation in the domain. In addition, IPERION HS will contribute joint innovative research for a better interoperability not limited to data, but including sample materials, methods and instruments. The networking activities in the project aim at reinforcing the binding in the group and at creating a sense of belonging for heritage science researchers which will exploit the RI services. IPERION HS consists of partners from 22 Countries clustered around their national nodes.

Keywords: heritage science,research infrastructure
Molecular mechanisms underlying synaptic maintenance and rejuvenation (HEALTHYSYNAPSES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

The deterioration of brain function and prevalence of dementias are some of the most striking and unfortunate consequences of ageing. Proper neuronal function relies on accurate signal transmission via synapses. While the basic cell biology of synaptic transmission is well studied, how precise activity is maintained over time remains poorly understood. Several age-dependent neurodegenerative conditions, characterized by the build-up of protein aggregates, affect synaptic function. These observations are consistent with a model where defects in the repair mechanisms that clear away defective proteins may constitute the basis for synaptic dysfunction and neurodegeneration. However, the processes that control protein rejuvenation at the synapse remain elusive. Autophagy is a process that is well suited for this purpose as it has emerged as a major means by which the cell can degrade dysfunctional components but a specific role for autophagy at the synapse has not been established. Levels in autophagy have been strongly linked to longevity and neuronal health. I hypothesize that autophagy plays an important role in synapse maintenance and that synaptic autophagy is disrupted during ageing and in neurodegenerative diseases. I will utilize a diverse set of approaches to elucidate the link between autophagy and changes in synaptic function during ageing in Drosophila. By generating novel optogenetic tools, I propose to test how the precise modulation of autophagy can influence synaptic function and whether boosting synaptic autophagy is beneficial in ageing and disease conditions. Furthermore, I will conduct a large-scale genetic screen for identifying genes regulating synaptic autophagy. Finally, I will explore the intriguing connections between synaptic proteins implicated in Parkinson’s disease and autophagy. Revealing the mechanisms underlying synaptic maintenance and health will help guide strategies for alleviating the undesirable effects of ageing.

Keywords: autophagy,optogenetics,presynaptic function,protein homeostasis
EcoSwing - Energy Cost Optimization using Superconducting Wind Generators - World’s First Demonstration of a 3.6 MW Low-Cost Lightweight DD Superconducting Generator on a Wind Turbine (EcoSwing)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Germany,France,Netherlands,United Kingdom,Denmark
Call: Demonstration of renewable electricity and heating/cooling technologies (H2020-LCE-2014-2, 2014)
Start date: 2015-03-01
End date: 2019-04-30
Duration (months): 50.0
Total project cost (EUR): 13846593.75
EU funding (EUR): 10591733.64
Participants: 9
Project status: CLOSED

EcoSwing aims at world's first demonstration of a superconducting low-cost, lightweight drive train on a modern 3.6 MW wind turbine. EcoSwing is quantifiable: The generator weight is reduced by 40% compared to commercial permanent magnet direct-drive generators (PMDD). For the nacelle this means a very significant weight reduction of 25%. Assuming series production, cost reduction for the generator can be 40% compared to PMDD. Finally, reliance on rare earth metals is down by at least two orders of magnitude. This demonstration is enabled by the increasing maturity of industrial superconductivity. In an ambitious step beyond present activities, EcoSwing will advance the TRL from 4-5 to 6-7. We are shifting paradigms: Previously, HTS was considered for very big, highly efficient turbines for future markets only. By means of cost-optimization, EcoSwing targets a turbine of great relevance already to the present large-scale wind power market. The design principles of EcoSwing are applicable to markets with a wide range of turbine ratings from 2 MW to 10 MW and beyond. Despite technological successes in superconductivity, turbine manufacturers and generator suppliers are hesitant to apply HTS into the wind sector, because of real and perceived risks. The environment inside a wind turbine has unique requirements to generators (parasitic loads and moments, vibration, amount of independent hours of operation). Therefore, a demonstration is required. The consortium represents a full value chain from materials, over components, up to a turbine manufacturer as an end-user providing market pull. It features competent partners on the engineering, the cryogenic, and the power conversion side. Also ground-based testing before turbine deployment, pre-certification activities, and training are included. EcoSwing can become tangible: The EcoSwing demonstrator will commence operation in 2018 on an existing very modern 3.6 MW wind turbine in Thyborøn, Denmark.

Keywords: superconductors,drive train,direct drive
Multilingual Children’s Speech Assessment Platform for Literacy and Language Learning (SpeechTech4Literacy)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Ireland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 2124175.0
EU funding (EUR): 1486922.5
Participants: 1
Project status: CLOSED

Literacy is a foundational skill, yet 20% of EU children have difficulty reading, unchanged over the past decade. This problem is more serious for disadvantaged and immigrant children, who lag even further behind in reading skills. Multilingualism is both a needed and desired skill across the globe. Speech technology has the potential to be a game changer by voice enabling digital literacy and language learning apps to ‘listen’ (and assess) as the child reads aloud, providing the child individual real-time feedback to rapidly improve reading and language skills and track student progress and difficulties. Adult speech technology systems don’t work for children and existing commercial systems for children are predominantly English and only work in quiet ‘lab-like’ environments, severely limiting their real-world use. SoapBox Labs (SBL) has developed a children's speech assessment platform for real-world conditions such as homes and schools and made the platform available for open license into 3rd party digital learning products, maximising potential for market penetration and impact. Our ambition is to extend our existing English platform, scaling to 13 languages by 2022 and targeting a global market of 187M children, €3B opportunity. SBL closed a €1.2M fundraise in Jan 17 and has received widespread support from leading academics, educators and industry stakeholders. SBL’s innovations will have a positive impact on children (through robust, widely accessible and affordable products), industry stakeholders (opening new product channels for education publishers, EdTech companies and developers) and SBL (international expansion with estimated revenues of €33M in 2022; 83 direct/indirect jobs). The project provides a major achievable step toward raising stagnant EU children’s literacy levels, reaching children no matter where they are, on everyday consumer mobile devices, opening a portal to learning and empowerment, particularly for the most vulnerable.

Keywords: kindergarten and primary education,school education,social economics,inequalities,social,mobility,reading,speech recognition,children,personalised learning