Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Modular Industrial Large-scaLE quaNtum computing with trapped IONs (MILLENION)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Framework Partnership Agreement
Countries involved: Austria,France,Spain,Poland,Germany,Netherlands
Call: Framework Partnership Agreement for developing the first large-scale quantum computers (FPA) (HORIZON-CL4-2021-DIGITAL-EMERGING-02, 2021)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 15
Project status: SIGNED

The MILLENION project focuses on modular scalability and accessibility aspects of trapped-ion quantum computers (QCs), tackling the transition from current laboratory-based experiments to industry-grade quantum computing technologies with technology readiness level above 8. The envisaged platform, which builds on top of the rack-mounted 50-qubit QC demonstrator realised in the flagship project AQTION, will offer a quantum advantage for various use-cases in a fully automated 100-qubit ion-trap QC. Our consortium will aggressively pursue disruptive development goals: (a) changing from one-dimensional strings of ions to two-dimensional arrays will allow us to support more than 1000 qubits; (b) consistently encoding quantum information in the electronic ground state of ion qubits enables error rates smaller than 10-4 per gate operation compatible with fault-tolerant error correction; and (c) implementing parallel gate operations will enable larger algorithmic depth. The new demonstrator device will be equipped with a hardware-optimised firmware suite and will be integrated in a high-performance computing (HPC) infrastructure to realise a QC/HPC solution, supporting standardised interfaces to various quantum software development kits with cloud accessibility. Finally, we will pave the way to scalable quantum computing by introducing long-range connectivity between quantum processors using photonic interconnects. We will combine these quantum information techniques with trap fabrication and packaging technologies which integrate optical and electronic components to achieve stable long-term operation in an industrial environment. These scientific and technological advances will provide a powerful hardware platform that can be exploited by partnering quantum software consortia to solve problems of major commercial and industrial importance such as computational problems in chemistry and machine learning.
New Sustainable Fe-rich Magnet using a predictive Alloy and Microstructure Design Toolbox (MAG-TOOL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 1499876.0
EU funding (EUR): 1499876.0
Participants: 1
Project status: SIGNED

Nd-Fe-B magnets are central to both green mobility and the generation of electricity from renewable resources. But the need to incorporate heavy rare earths like Tb and Dy –highly critical raw materials– to operate these magnets above 100 °C (required for electric vehicles and wind turbines) makes them very costly, environmentally damaging, and with a very fragile value chain. And despite four decades of effort, no practical alternative to Nd-Fe-B has been found. SmFe12-based compounds have superior intrinsic magnetic properties, actually surpassing those of benchmark Nd-Fe-B and, without the need for additional heavy rare earths. The challenge with SmFe12 is phase instability in the bulk form and creating a microstructure that will convert the large intrinsic anisotropy field into a usable coercivity. What we know so far is that the solution lies in combining multiple alloying elements, each one impacting differently. In Sm(Fe,M,X,Z)12, for example, 20 alloying elements results in around ≈10^8 combinations (“experiments”), if each element varies from 1 to 15 at.% in quinary compositions. MAG-TOOL will create a cutting-edge toolbox that combines experimental techniques with state-of-the-art machine-learning algorithms, eliminating the need for trial-and-error. This breakthrough approach drastically reduces the number of experiments from a daunting ≈10^8 down to a manageable ≈10^2. MAG-TOOL will achieve that by breaking the multi-element complexity, starting to predict the compounds with useful phases using only three elements. This knowledge will be transferred to multi-element situations and combined with robust experiments to deliver superior magnetic properties in powders and melt-spun ribbons. MAG-TOOL will also include a laser-deposition, additive-manufacturing system for rapidly creating many compositions within the same bulk samples through compositional gradients. The outcome of the project will be the new medium- and high-performance sustainable magnet.

Keywords: permanent magnets,machine learning,powder processing,phase diagrams,additive manufacturing,magnetic properties,microstructure
Astrogeodesy by VLBI Global Observing System (Astrogeodesy)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1498984.0
EU funding (EUR): 1498984.0
Participants: 1
Project status: SIGNED

Very Long Baseline Interferometry (VLBI) is a powerful technique in astronomy to generate the most detailed radio images of exotic astronomical objects, mostly Active Galactic Nuclei (AGNs); in geodesy, it enables both societal and scientific applications through its unique and essential role in defining the reference frames that underpin GNSS and its many applications. Some scientific applications of geodesy, such as monitoring sea level rise, require high levels of precision and accuracy. The next generation VLBI system, the VLBI Global Observing System (VGOS), is being developed with the ambitious goal of achieving, on global scales, the accuracy of 1 mm in station position and 0.1 mm/yr in station velocity. For a long time it was thought that the radio propagation medium was the dominant error source and hence considerable effort was invested towards its reduction. However, in more recent years, partly thanks to the pioneering work of the PI, it has become clear that the true potential of geodetic VLBI can never be reached without understanding and correcting for the distortions caused by the angular structure of the AGNs (i.e. distribution of the radio emission on the sky). The Astrogeodesy project will (1) study, characterize, monitor, and interpret the frequency- and time-dependent structure of the AGNs based on VGOS observations and (2) develop approaches to model them as point-like fiducial anchors on the sky. The aim is to close the gap between current capabilities and the target goal of 1 mm accuracy by combining the three disciplines of geodesy, astrometry, and radio astronomy. At the same time, this combination will in return enable VGOS to be a powerful tool providing data to enhance these three fields. About 30 VGOS antennas have been or are being built across the world, and regular VGOS observations are carried out with the completed antennas. It is timely to develop a new data calibration and analysis concept for VGOS through this project.

Keywords: very long baseline interferometry,geodesy,terrestrial reference frame,active galactic nuclei
Deciphering host-gut microbiota spatio-functional plasticity in inflammation (ExtractABact)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-02-01
End date: 2028-01-31
Duration (months): 60.0
Total project cost (EUR): 1997500.0
EU funding (EUR): 1997500.0
Participants: 1
Project status: SUSPENDED

Over the past two decades, gut bacteria have emerged as major regulators of human health. The focus in the field thus far has been on bacterial taxonomy, with their spatial organization and functionality largely overlooked. Crohn’s disease (CD) vividly portrays this spatiofunctional dimension, as it features patches of gut inflammation (skip lesions) surrounded by uninflamed regions—in the same host—with a clear demarcation but unknown cause. Our preliminary data demonstrate host-microbe functional feedback loops in which bacterial strains can adapt and modify their immunomodulatory functions in response to the host. Moreover, we find functional alterations in gut bacteria of IBD patients. Thus, we hypothesize that bacterial spatio-functionality can be largely affected by host physiology, and, in turn, modulate the pathophysiological state, creating a functional feedback loop. We propose to study bacterial spatiofunctional plasticity and mechanisms of host-microbe interactions in CD, and their potential causal effects on inflammation, combining microbiology, immunology and systems biology approaches. We intend to focus on three independent yet complementary aims: (1) Characterize host-microbe spatio-functional alterations in skip lesions and assess their potential causal effects on inflammation; (2) Decipher the functional and molecular mechanisms of host-microbe feedback loops in healthy and inflamed intestines; and (3) Develop a toolbox for high-resolution functional analyses of gut bacteria directly in their natural environments. This study will address, for the first time, bacterial functional plasticity in response to host inflammation, unveiling the phenomena, its mechanism of action, and potential causal effects on gut inflammation. Such understanding can shift our perception on microbiota-host interactions, may explain contradictions in the field, point to novel contributing factors to CD and related disorders, and guide future translational studies.

Keywords: microbiome,inflamatory bowel disease,crohn s disease,bacterial functional plasticity,feed back loop interaction,phase variation
Regenerated Cotton for Electronic Textiles (RETEX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Türkiye,Belgium,Romania,Austria,Italy,Estonia,Germany
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 969942.86
EU funding (EUR): 814200.0
Participants: 14
Project status: SIGNED

The main objective of the RETEX MSCA SE project is to form a world class international and inter-sectoral network of organizations, working on a joint research programme in the field of novel Sustainable Electronic Textile Materials, by replacing conventional textile materials with sustainable, environmentally friendly, and advanced materials such as; regenerated fibres from cotton fabrics. This can only be achieved by bringing together world-class experts in materials, polmers, environmentalists, chemists, software engineers, and designers with state-of-the-art innovations and processes in their respective fields of expertise. The participants will exchange skills and knowledge to create sustainable textile materials, strengthening collaborative research between different countries and sectors. RETEX will also refine and produce potential commercial market opportunities for non-academic participants in the project .Our goal is to train next generation of researchers and innovators in sustainable textiles through cross-sectoral and training modules. The staff members will develop new skills, be exposed tonew research and innovation environments, international networks, new industrial processes and techniques whilst widening and enriching career development through cross-sectoral knowledge transfer and international mobility.

Keywords: textile based sensors,sustainability,electronic textiles,cotton,conductivity,regenerated fibres,
Trends on educational inequalities over time and successful interventions that contribute to reverse them (REVERS-ED)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Spain,Lithuania,Belgium,Greece,Italy,Finland,Portugal,Ireland,Denmark,Bulgaria,Romania
Call: Mapping of longitudinal data and assessment of inequalities in education, training and learning achievements (HORIZON-CL2-2023-TRANSFORMATIONS-01, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 2575606.25
EU funding (EUR): 2575606.25
Participants: 14
Project status: SIGNED

Research through the decades has demonstrated the existence and persistence of educational inequalities. These inequalities particularly affect vulnerable groups of students such as those with low socioeconomic status or a migratory history, who more frequently show high rates of early school leaving and low school performance. However, there is increasing scientific literature which identifies educational interventions that are effective in compensating for these inequalities, overcoming deterministic analyses in the understanding of the educational trajectories of vulnerable children and youth. Taking this into account, this project will have a double approach. On the one hand, the project will exploit the large volume of existing educational data at the national and regional levels to map and analyse educational inequalities from a longitudinal perspective, identifying key features and trends. For the analysis, retrospective cohort studies will be conducted to understand how educational inequalities have evolved in recent years and how they relate to characteristics of the education received. On the other hand, the existing interventions that compensate for these inequalities will be studied in depth. Longitudinal analysis (quantitative and qualitative) will be performed of the educational trajectories of children and youth who have participated in successful educational interventions already identified by scientific research, to better understand how and to what extent they contribute to improve learning outcomes. With these analyses, this project aims to facilitate that effective interventions can be translated into policies and replicated to advance into more inclusive educational systems with better learning outcomes for all. Additionally, the project will allow a better knowledge of the type of data to collect and how to collect them, to be able to make informed decisions towards overcoming educational inequalities in the short, medium, and long term.

Keywords: learning outcomes,educational inequalities,educational policies
Melding behavioural ecology and biomaterials research to track the evolution of mechanical super-performance of spider silk composites (SuPerSilk)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1788003.0
EU funding (EUR): 1788003.0
Participants: 1
Project status: SIGNED

Many organisms assemble biological materials into architectures and tools that add and extend biological functions - with profound ecological effects, and inspiring human technologies. However, there is no general concept of how evolutionary bio-material innovation arises from both the physiological and the behavioural recombination of compounds. SuPerSilk aims to understand how mechanical super-performance evolves by disentangling the concerted effects of both physiological and behavioural factors on structure-function relationships, utilizing spiders and their silk products as a model system. Specifically, SuPerSilk will (1) determine if the diversification into different types of silk glands facilitated the evolvability of spider silk performance, (2) test if the behavioural combination of different spider silks into compound threads provides a fast track for the evolution of thread performance and an extension of performance limits, (3) test whether similar thread functions evolved via repeated or alternative pathways, and (4) establish a roadmap for the targeted bioprospecting of silk compounds with specific properties. Being the first project that will jointly track the evolution of base materials and their behaviourally assembled compound products, SuPerSilk will address a timely question in evolutionary biology: if and how the evolvability of physical traits can be modified by the evolution of novel behaviours and vice versa. The outcome will be a precedent for the integrative study of animal products that will establish a new line of research: evolutionary materials. In addition, by probing the structure-function relationship of behaviourally assembled silk composites, SuPerSilk will reinvigorate efforts to develop super-tough biofibres for industrial applications, a field that has stagnated in recent years, and enable the engineering of bio-fabrics with tailorable properties.

Keywords: mechanical properties of biological materials
Adipose tissue-Liver Macrophage CrossTalk in NASH and Fibrosis (MacTalk)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2025-06-30
Duration (months): 34.0
Total project cost (EUR): 204937.05
EU funding (EUR): 204937.05
Participants: 1
Project status: CLOSED

Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis and damage. This drives liver inflammation, promoting the progression to non-alcoholic steatohepatitis (NASH) and liver fibrosis. There are currently no approved therapies for NASH and fibrosis, which is in part due to a lack of knowledge of the immunological events underpinning NASH and fibrosis. The pathogenesis of NASH is strongly influenced by crosstalk with other tissues. There is increasing evidence that specifically obese adipose tissue macrophages (ATMs) are directly linked to liver pathology. In this respect, the host lab has shown that obese ATMs increase hepatic macrophage number. However, the exact changes in macrophage subsets and phenotypes were not investigated. I recently demonstrated that in NASH liver macrophages display large heterogeneity in phenotype and tissue localization and this plays a key role in NASH-associated liver fibrosis. Based on this combined preliminary data generated by the host lab and me, I hypothesize that ATMs alter hepatic macrophage composition and consequently affect the progression of NASH to liver fibrosis. By combining the mouse models and expertise available in the host lab and advanced technology present at the host institute, with my expertise in detailed immunophenotyping of the liver in NASH and fibrosis, I will address this innovative hypothesis in great detail. To bridge the translational gap from animal studies, I will investigate the potential contribution of ATMs to hepatic inflammation and fibrosis in humans by using unique fresh paired adipose tissue and liver biopsies available through the clinical network of the host lab. MacTalk integrates the scientific and technical expertise of both me and the host lab, creating a unique framework to identify novel mediators of hepatic inflammation and fibrosis. Furthermore, MacTalk will lay a strong foundation for my future career as independent researcher in the field of liver fibrosis.

Keywords: fatty liver disease,nash,liver fibrosis,macrophage,organ crosstalk,flow cytometry