Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
New therapies for myeloproliferative diseases based on multi-stage and -system analyses of the haematopoietic stem-cell niche (StemNicheOnWaveCrest)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-02-28
Duration (months): 66.0
Total project cost (EUR): 1594500.0
EU funding (EUR): 1594500.0
Participants: 1
Project status: CLOSED

Blood cells are produced in the bone marrow, which contains two distinct adult stem cell types: haematopoietic stem cells (HSCs), that generate all blood and immune cells, and mesenchymal stem cells (MSCs), thought to form the skeleton. HSCs traffic between bone marrow and circulation, what allows for life-saving clinical transplantation. Our previous work has shown that HSC numbers in blood are regulated by the central pacemaker in the brain, which reaches bone marrow nestin+ MSCs through the nerves. Contrarily to what it was believed, our recent data suggest that HSC-niche MSCs are different from those that form the skeleton and share instead a common origin with peripheral nerves and supporting glial cells. Thus, tight regulation of the bone marrow stem-cell niche in vertebrates might build upon developmental relationships of its cellular components. Moreover, we have shown that damage to this regulatory network is essential for the manifestation of myeloproliferative neoplasms, diseases that were previously thought to be driven solely by mutated HSCs. Also, JAK inhibitors (blocking the most frequent HSC mutation found in myeloproliferative neoplasms) cannot eradicate leukaemia stem cells. Our recent data has uncovered a selective regulation of normal and leukaemic haematopoietic progenitor maintenance, survival and division by sex hormones (oestrogens). These results might explain gender differences in blood cancer incidence and they also offer a new way of targeting leukaemia stem cells with clinically approved drugs. Nevertheless, we anticipate that the ideal future treatment of myeloproliferative diseases should target both leukaemia stem cells and their microenvironment. We have shown that protection or rescue of the niche is able to control the expansion of mutated cells. We aim to study this novel neuroendocrine regulation of bone marrow stem cells that will potentially fructify in new therapies for incurable myeloproliferative diseases.

Keywords: myeloproliferative diseases,chemotherapy,haematopoietic stem cell niche,mesenchymal stem cells,sympathetic nervous system,oestrogens
A cost-effective production process to open worldwide the cultured meat market (CULTURED BEEF)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Livestock farming is putting a significant pressure over the environment. Globally, the livestock sector uses 70% of the arable land and emits 15% of all human-induced greenhouse gas (GHG) emissions. If an alternative to the current meat production systems is not found, the situation would only worsen given the fact that meat demand is expected to increase globally by 73% by 2050. Livestock environmental impact, together with animal welfare issues and meat content on saturated fats, is pushing the EU population to cut-down meat consumption and shift to meat substitutes (tofu, tempeh…). For example, 38% of the French, 35% of the Dutch or 17% of the Spanish, are actively choosing to eat less meat. The main reason to take that decision is animal welfare (30%) followed by environmental concerns (22%). However, this choice reduces their meal options and makes it harder to follow a well-balanced diet since meat is an excellent source of high quality proteins and the only dietary source of vitamin B12 (an essential nutrient). Encouraged by this issue, our SME Greenfoods Network started the project CULTUREDBEEF, aimed at obtaining and at marketing beef meat from the culture of dairy cattle muscle cells. To do so, we have developed an innovative and cost-effective production process that will allow us to be the first company worldwide to place in the market cultured beef burgers at a competitive price. Thanks to our solution, the EU population will be able to eat high-quality and environmentally-friendly beef meat, since our product (i) doesn’t imply animal slaughtering, (ii) needs 99% less land, 82-96% less water and emits 78-96% less GHG emissions than conventional meat and (iii) contains 60% less saturated fats than conventional beef meat. We will launch it to the Spanish market in 2021 and reach different EU countries (FR, NL, DE, DK, FI, SE) during the first five commercialization years, obtaining almost 6M€ of profit and creating 20 jobs positions.

Keywords: cultured meat,livestock,environment,cell culture,new market,new product development
Corrugated sheet Application of Solar npo’s for Asbestos Replacement in Argicultural Real-Estate (CASARAR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Sunchip Projects B.V. is a full subsidiary company of Weijland Beheer B.V. and a strategic partner of Weijland Technologies B.V. Within the group a proprietary optimizer technology (Nano Power Optimizer- NPO) has been developed that offers a solution to inefficiencies of the series connection in solar panels. It has also integrated that technology with a traditional roof tile (NanoTile) to enhance viable residential photovoltaic locations (NanoTile), improves shading and soiling inefficiencies up to 15% and provides an affordable off the grid solution for clean sustainable energy generation. The technology is set to further be developed in a Corrugated Sheet Application. Value Proposition: An integrated solar roof solution that improves shading and soiling inefficiencies from PV panels by increasing output generation of electricity by 15% , lowers cost up to 25% and is the fraction of the size of a regular PV panel. This project aims at studying the feasibility of such a development from business, technology, production and economic perspective.

Keywords: building integrated photovoltaics,asbestos removal,prevention,solar energy efficiency
Virulence Activities of the Metalloprotease Effector AVR-Pita from the rice blast fungus Magnaporthe oryzae (VAMEAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-04
End date: 2023-01-03
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Plant diseases are a major constraint on food production. To rationally design efficient and resilient disease control strategies, it is essential to understand the molecular mechanisms underlying pathogen virulence. Most pathogens rely on secreted proteins called effectors to manipulate the host machinery for their benefit and perform their life cycle. In VAMEAP, we propose to characterize the virulence activities of the metalloprotease effector AVR-Pita from Magnaporthe oryzae, the causal agent of rice blast disease. Despite a strong selection pressure against this effector, AVR-Pita is maintained in populations of the pathogen suggesting a crucial role for the fitness of M. oryzae. Yet, next to nothing is known about the virulence activities or host targets of AVR-Pita. Here we propose an ambitious combination of biochemical and functional approaches to bridge this knowledge gap. We will survey the natural diversity and sequence polymorphisms in AVR-Pita and investigate the impact of its loss on the fitness of M. oryzae. We will identify the virulence targets of AVR-Pita using protein-protein interaction screens and characterize the protease activity of this effector. Beyond the knowledge that this project will gather on AVR-Pita, it will also help to understand the biology of metalloprotease effectors commonly found in fungal pathogens. The multidisciplinary approach developed in this project will be a powerful tool to further understand fungal virulence and help design new resistance strategies to control fungal crop diseases.

Keywords: rice,magnaporthe oryzae,effector,metalloprotease
Enhancing the innovation management capacity of SMEs through the Enterprise Europe Network in Macedonia (INNO EEN-M) (INNO EEN-M)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: North Macedonia,North Macedonia
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 9082.5
EU funding (EUR): 9082.5
Participants: 3
Project status: CLOSED

The general objective of the INNO EEN-M project is to increase the economic returns from innovation and enhanced innovation management capacities of the Macedonian SMEs through offering a standardised set of coaching and innovation management services while ensuring synergy with other services of the Enterprise Europe Network in Macedonia (EEN-M). The project aims to deliver 13 (thirteen) 7-day service packages: 10 package services will be provided to SMEs with significant innovation activities and high potential for internationalization and 3 packages for the SME instrument beneficiaries. As the national consortium is responsible for providing services at whole territory of the country, this project will also cover the same area. The services will be delivered by three innovation experts/Key Account Managers (KAM) from UKIM, member of EEN Macedonia. The INNO EEN-M project is highly related to the call for Enterprise Europe Network – Horizon 2020 (2019) and will provide necessary tools, knowledge and experience to the EEN-M for implementation of the specific activities in the context of innovation support. The activities within the project are organized in two work packages: key account management (KAM) for the beneficiaries of the SME instrument, FTI and FET-Open and enhancing SME innovation management capacities for innovating SME independently from a specific project. The selection of SMEs will be done based on identified criteria whereas services will be delivered in line with the specific common format with the packages. The team will use the IMP³rove tool as an assessment tool. The KAM will undertake needs analysis/coachcom tool to support SMEs in selection of lead coach. The planned duration of both work packages is 12 months (2019). The services, benefits and experiences from these activities will be part of internal evaluation. The beneficiaries of these activities will be also used for identification of potential needs for training in the future.

Keywords: innovation,smes
Neuronal networks from Cortical human iPSCs for Machine Learning Processing- NEU-ChiP (NEU-ChiP)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,Israel,Switzerland,France,United Kingdom,United Kingdom
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 3461780.0
EU funding (EUR): 3461780.0
Participants: 6
Project status: SIGNED

The EU and the rest of the world increasingly rely on artificial intelligence (AI) and machine learning (ML) for everyday functioning. Applications range from decision making in areas such as health and finance, face recognition, autonomous vehicle control, speech recognition and interaction with the internet and social media platforms. Estimated annual global spend on ML and AI is $77.6B in 2022 with a business value of $3.9T. However, current deep-learning machines suffer from inherent and difficult limitations: architectures not adaptable, ineffective learning rules, long training times and computing power, making advances unsustainable. The NeuChiP project will tackle this issue. We will use emerging stem cell technology to make human neuronal networks that self-organise developmentally using the rules that form the brain. Networks will be made of layered cortical structures and hubs, with guided directional network connections and housed in a fabricated assembly. Input will be by patterned light at cells expressing optogenetic actuators, and output recorded via high resolution 3D multielectrode arrays. Intrinsic physiological mechanisms will enable them to undergo plasticity to designated input patterns. NeuChip will surpass the abilities of conventional artificial neural networks by conducting tasks in dynamically changing environments, exploiting the adaptive, complex and exploratory nature of biological human neural systems. To achieve this we have assembled a cross-disciplinary consortium of neuroscientists, stem cell biologists, bioelectronics developers, statistical physicists, together with machine learning and neuromorphic computing experts. We expect that within 15 years NeuChiP technology, using biological learning rules and powerful human-brain-based circuits will lead to novel and widespread advances in machine learning abilities and beyond, leading to a paradigm-shift in AI technology and applications to benefit society.

Keywords: machine learning,probabilistic inference,physics of disordered systems,information theory,neural engineering,lab on a chip
Exploring the Limits of Mass Transport in Electro-Chemical Energy Converters ThRough uncOnstrained Design and Interface Engineering (ELECTRODE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany,Norway
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-05-01
End date: 2026-08-31
Duration (months): 64.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1323941.25
Participants: 2
Project status: SIGNED

A promising option to store and transport clean energy are electrochemical fuels that can be converted to electricity on demand. Fuel cells, electrolysers and flow batteries are used for conversion to and from fuel and have advantages over batteries as storage capacity is cell size independent. Reactant and product transport set the maximum current density obtainable determined by the interplay between multiphase and opposing vapor and liquid flow. To understand this limit, a better way of controlling transport of reactant and products within electrodes is necessary. In particular, we need to (1) tune convection for distributing reactant concentration, (2) tailor the interplay between Knudsen and bulk diffusion, (3) tailor capillary forces to remove liquid products and (4) ensure fast reaction kinetics through reducing the reaction energy barrier. Electrode design is hence key, yet current architectures provide limited control over feature sizes, length scales and geometrical complexity, making the study of transport mechanisms tedious and controlled experiments difficult. We propose a radically new way of studying mass transport in electrodes via the direct conversion of multiscale computer designs into physical glassy carbon electrodes with desired surface functionality. We propose to (i) develop a photopolymer based AM process for tailored glassy carbon architectures with features ranging over multiple length scales, (ii) study the interplay between convective flow and diffusion throughout the electrode architecture, (ii) geometrically separate reactant and product transport, (iii) study and improve liquid product management and (iv) create catalytically active nitrogen doped carbon architectures potentially omitting the need for noble metal catalysts. ELECTRODE will improve our understanding of mass transport and arrive at a new toolbox for designing electrode architectures that may generate knowledge for next generation energy conversion and storage.

Keywords: mass transport,glassy carbon,photopolymer,additive manufacturing,electrochemical flow converters,fuel cells
MEthane activation via integrated MEmbrane REactors (MEMERE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Spain,Belgium,Switzerland,Belgium,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: New adaptable catalytic reactor methodologies for Process Intensification (H2020-SPIRE-2015, 2015)
Start date: 2015-10-01
End date: 2020-01-31
Duration (months): 52.0
Total project cost (EUR): 5428858.75
EU funding (EUR): 5428858.5
Participants: 14
Project status: CLOSED

The key objective of the MEMERE project is the design, scale-up and validation of a novel membrane reactor for the direct conversion of methane into C2H4 with integrated air separation. The focus of the project will be on the air separation through novel MIEC membranes integrated within a reactor operated at high temperature for OCM allowing integration of different process steps in a single multifunctional unit and achieving much higher yields compared with conventional reactor . To achieve this MEMERE aims at developing novel, cheap yet more resistant oxygen selective membranes (target costs < 5000€/m2) for efficient air separation and distributive oxygen feeding to the reactor. The objective is to give a robust proof of concept and validation of the technology (TRL 5) of the new technology by designing, building, operating and validating a prototype module based on the OCM technology that will be integrated in a mini-plant built in containers. MEMERE technology will deliver direct conversion of methane to C2+ with a reduced energy penalty in a much effective way (target C2 yields >30%) as compared to currently available techniques contributing to the implementation of the Roadmap and Implementation Plan for process intensification of the SET-Plan. Additionally, as air integration is integrated in an efficient way in the reactor, the MEMERE technology can be used a small scales to convert methane produced in remote areas where conventional technologies cannot be exploited.

Keywords: membranes,membrane reactors,methane conversion,ethylene production,prototype testing,energy analysis
Advanced Surgical Implants (ASURI) (ASURI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Hungary
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-07-01
End date: 2016-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The ASURI project at DO3D Innovations Ltd. aims to enter the 3D – printed medical implant and surgical guide market with a 3D printing service that integrates the whole medical implant and surgical guide design and manufacturing process. Our solution is innovative, safe, fast, cost effective and unquestionable from a healthcare and regulatory perspective. The novelty of our solution lies in the integration of castable 3D printing techniques with high precision casting in the area of medical implants: traditional implant manufacturers cannot provide patient specific implants or surgical guides, while 3D-printed implant manufacturer service providers work with SLM technology, which is slower and more expensive. Key benefits of our solution are: • it provides an alternative for expensive surgical equipments or navigation systems with also keeping the level of efficiency close to them, or claiming for even higher efficiency • applying our service to hospitals having no resources for such operational equipment allows them to successfully perform more complex interventions • integrates presurgical planning in the traditional process • patient specific, taylor made surgical devices provide better treatment, faster healing process and lower rate of failure leading to an improved medical outcome • patients with complex pathologies can be treated who cannot be cured with traditional solutions • makes revisional surgeries easier • our new DLP printing technology provides a 2-times faster printing speed than currently commercially available printers, which ensures a cost and time effective manufacturing. This project creates a Europe-wide and global business opportunity for DO3D. Our project is supported by our strategic partners as well.

Keywords: 3d printing,healthcare,disruptive innovation,surgical guides,personalized implants