Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Constructing chiral molecules merging ELECTRochemistry and ORGANOcatalysis (ELECTRORGANO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

Drug discovery must identify successful lead candidates. As such, the development of new catalytic methods for the production of chiral molecules is extremely valuable. ELECTRORGANO seeks to synergistically combine two powerful modes of molecule activation, namely asymmetric organocatalysis and microfluidic electrochemistry, to provide an attractive new pathway for the formation of demanded chiral molecules. Both organocatalysis and electrochemistry possess extraordinary potential for the sustainable preparation of novel organic molecules, which are required to drive innovation within the pharmaceutical industry. However, the implementation of electrochemical methods for the design of stereoselective processes is still falling short, mostly due to the fleetingness of the radical ions intermediates generated on the electrode surface. ELECTRORGANO asks whether the use of an electrochemical microfluidic setup, coupled with asymmetric organocatalysis, can overcome these intrinsic limitations, rapidly providing chiral building blocks with high stereocontrol. Finally, mechanistic studies, aided by the use of in-line instruments, will provide fundamental understanding in the origin of the enantioselective induction, setting the stage for future breakthroughs in enantioselective electrochemistry. This project is highly interdisciplinary, involving different research areas such as asymmetric organocatalysis, electrochemistry, and microfluidics. As such, it is envisioned that the development of this new platform can generate breakthrough scientific papers, valuable discoveries and/or potential patents. This fellowship brings a two-fold transfer of knowledge: advanced techniques in asymmetric catalysis to the host institution and electrochemical methods and microfluidic flow chemistry to the fellow. Overall, the project’s multidisciplinarity and intersectoral nature will broaden the fellow’s competencies and will place him in a competitive position for his next career move.

Keywords: flow chemistry,organocatalysis,catalysis,nhc catalysis,aminocatalysis,enantioselective reactions,electrocatalysis
Novel Nanoporous PZT Materials for Efficient Utrasonic Biomedical Sensors (Nano-PieZoelecTrics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-11-02
End date: 2018-11-01
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Piezoelectric materials have become a key technology for a wide range of industrial and consumer products with a robust global market of U.S. $21 billion in the last 2013. Current technology includes applications on actuators, ultrasonic motors, sensor arrays for structural health monitoring, transformers, micro-energy harvesting devices, hydrophones, high resolution ultrasonic medical imaging, computer disk drives, and accelerometers in mobile phones and notebooks. Currently the most important piezoelectric ceramic materials are based on mixed oxide crystal system consisting of lead, zirconium and titanium, well known as lead zirconate titanate (PZT). Cost-effective and efficient synthetic strategies, structural modifications and doping by foreign ions represent the key steps to significantly improve the performance of PZT materials, such as piezoelectric, dielectric and mechanical stability properties. In this frame, we purpose a new research methodology based on the preparation, characterization and testing of hierarchical porous PZT-doped using alternative synthetic approaches (EISA method) and new doping materials (porous Mg-Niobate, Graphene/Molybdenite and Nanocellulose) to achieve important innovations and overcome the current state of art on the field of hydrophones and high resolution ultrasonic medical applications. Innovations are represented by the preparation of highly-efficient porous PZT matrices, not yet reported in the literature, with very-high surface area whit the idea to enhance the contact between PZT-matrix and media (water, medical gels, etc) and then increasing the sensibility and piezoelectric response of the device. Regarding new doping approaches, Nb-source will be nano-confined into the PZT matrices using the pores as hosting elements with the advantage of constraining dopants in nanoscale. Graphene/Molybdenit nanocomposite and Nanocellulose will be also used to replace critical Nb as also recently recommend by the European guidelines.

Keywords: piezoelectric ceramics,porous pzt,biomedical imaging,nanomaterials,magnesium niobate,highly ordered mesoporous matrix
REGENERATING LARGE BONE DEFECTS (REGENERBONE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France,France
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-04-01
End date: 2019-09-30
Duration (months): 18.0
Total project cost (EUR): 149998.71
EU funding (EUR): 149998.71
Participants: 2
Project status: CLOSED

In the field of orthopedics and maxillo-facial surgeries, there is still no satisfying solution to repair critical size bone defects. Autograft, which is the current gold standard, presents several drawbacks, including prolonged pain on donor site and higher infection risks. It needs to be replaced by efficient, safe and easy-to-use strategies. Some synthetic bone grafts are providing mechanical and osteoconductive properties, but there is a need to introduce a bioactive molecules, such as a growth factor or a peptide, to trigger actively bone repair. These “orthobiologics” products are appealing since they trigger stem cell activation in situ. There are several approved products containing orthobiologics on the market for bone regeneration, but the physiological delivery of orthobiologics remains a challenge: severe adverse effect have been reported due to the supra-physiological dose of biologics used. In addition these product do not provide structural properties which is necessary for critical size defect reconstruction. Ideally the carrier for the bioactive molecules should be appropriate and enable a spatially/temporally-controlled molecules delivery with physiological dose. Our nanomedicine technology consists of an osteoinductive biomimetic films that can be deposited on architectured implant of any shape and material (ceramics, polymers, metals). The aim of REGENERBONE is to advance our technology toward a clinical application in maxilla-facial surgery and orthopedics. This will be done by conducting pre-clinical trials in large animals, doing a market search, securing the sourcing of the film components and building a business model. The successful results we obtained recently in the frame of the ERC BIOMIM and Proof-of-Concept OSCODI are the basis for REGENERBONE, which goes a step beyond in the long process of introducing an innovative medical device to the market in an era of personalized medicine.

Keywords: implants,bone repair,nanomedicine,biomimetic coating,personnalized medicine,scaffold,growth factor
Energy management competition for local authorities for uptake and enhance of Sustainable Energy and Climate Action Plans (COMPETE4SECAP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Germany,Germany,Spain,Italy,Germany,Cyprus,Croatia,Hungary,Latvia,France
Call: Engaging and activating public authorities (H2020-EE-2016-CSA, 2016)
Start date: 2017-10-01
End date: 2020-12-31
Duration (months): 39.0
Total project cost (EUR): 1781483.75
EU funding (EUR): 1781483.75
Participants: 10
Project status: CLOSED

All over Europe, a good level of knowledge about Sustainable Energy Action Plan (SEAP) development has been reached. There are different good quality methodologies and guidelines available. However, currently municipalities struggle to implement these action plans. There are different reasons for that; one of the most important is the fact that often municipal employees do not feel engaged and are not motivated to take any sort of actions and initiatives, unless someone has actually “obliged” them. In many cases, this lack of engagement and commitment ends up with investments in energy efficiency that do not deliver expected technical and economic outcomes. Hence, the energy efficiency potential is not fully exploited and worse suboptimal investments do not provide expected yields. Moreover, local authorities (LAs) more often are facing also challenges regarding climate resilient infrastructure and climate adaptation. The level of knowledge and understanding is even scarcer as regarding climate mitigation. COMPETE4SECAP is designed to deliver a systematic approach to energy savings in local authorities using energy management systems (EnMS) according to ISO 50001 or European Energy Award with dedicated online monitoring tool and energy saving competitions. EnMS and competitions when combined can trigger significant benefits by providing innovative and efficient way to involve municipalities that have already their SEAPs but do not act in order to foster their integrated development at local level. Trained and engaged municipal employees will be able to better implement energy efficiency projects, which then require higher investments. An EnMS will help the LA to have reliable data for informed decision and further help in monitoring and evaluation of implemented projects. The use of renewable energy and integration of climate adaptation will also be facilitated through EnMS with the set of procedures from an environmental management system (e.g. IS0 140001).
A nanovaccine Approach for the treatment of Pancreatic Cancer (PAVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Spain,Norway,France,Netherlands,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-10-01
End date: 2024-03-31
Duration (months): 54.0
Total project cost (EUR): 4023616.68
EU funding (EUR): 4023616.68
Participants: 15
Project status: SIGNED

A Nanovaccine Approach For The Treatment of Pancreatic Cancer By Multicomponent Immuno-Modulation: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer deaths in men and women and still fatal in over 90% of patients. It is characterised by its extremely aggressive nature where it is also responsible for the highest mortality rate compared to other major cancers, resulting in excess of 250,000 deaths worldwide per annum. Current state-of-art therapies for advanced PDAC including chemo- and/or radiotherapy, despite extensive efforts, have met with only limited success. Surgery is only applicable for those with early stages of the disease, or to relieve symptoms, if the cancer is blocking the bile duct or the bowel. There are two major reasons for the resistance of PDAC to conventional therapy. Firstly, PDAC has a very defining hallmark, where an abundance of stromal content is present in the tumour microenvironment (TME) to form a physical and biochemical barrier. Secondly, during progression of the disease, the body's immune system is hijacked to support the proliferation of the cancer. New approaches, such as immunotherapy, are therefore needed where it has already shown promise in overcoming many aspects of this resistance. Immunotherapy has the potential to treat minimal residual disease after pancreatic resection (surgery) as well as for metastatic and non-resectable PDAC. Our objective for this project is to bring together a multidisciplinary and intersectoral group to develop novel vaccine approaches, including use of multiple immunomodulating components.

Keywords: nanovaccines,immunotherapy,personalized nanomedicine approaches,image guided,surgery,molecular imaging
Photonic Metaconcrete with Infrared RAdiative Cooling capacity for Large Energy savings (MIRACLE)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Spain,Spain,Belgium,France
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-02-01
End date: 2025-01-31
Duration (months): 48.0
Total project cost (EUR): 3192466.25
EU funding (EUR): 3192466.25
Participants: 8
Project status: SIGNED

This project envisions a new science and technology that turns low-tech concrete and cement-based materials into high-tech functional photonic metamaterials. In particular, the MIRACLE project will construct and test a revolutionary Photonic Meta-Concrete (PMC) whose response to light will be engineered for exhibiting radiative cooling ability; i.e. the PMC will be able to expel heat from buildings to the outer space without any extra energy consumption. Though this ambitious challenge can have a big impact in the Nearly-Zero-Energy-Buildings (NZEB) uptake, the concept of PMC transcends this particular application, with multiple implications in avenues like solar cell-technology or communication technologies, for example. Radiative cooling technology utilizes the atmospheric transparency window to passively dissipate heat from the Earth to outer space. This technology has attracted wide interest from both fundamental and applied sciences, due to its a priori potential in multiple applications like building cooling, renewable energy harvesting, or even dew water production. However, currently the development of this technology is in a bottleneck, where the scientific ideas have negligible potential impact in any real-world energy solution. In this context, the MIRACLE consortium proposes a considerable advance in the state-of-the-art because it will address for the first time an effective and fully scalable solution based on steel microfibre reinforced concrete ! The idea of MIRACLE is to propose new designs where an ordered arrangement of the steel microfibres can work in combination with hierarchical porous structure of concrete as a PMC. For this challenging objective, advanced optimization methods based on deep learning technologies will be employed at the design level, while the fabrication will rely on an inverse-phase methodology where micro-patterned concrete mould will be produced by two-photon-polymerization (2PP).

Keywords: photonic metamaterials,radiative cooling,concrete,reinforced concrete
Increasing scientific, technological and innovation capacity of Serbia as a Widening country in the domain of multiscale modelling and medical informatics in biomedical engineering (SGABU)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Austria,Belgium,Greece,Serbia,United Kingdom,United Kingdom
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2020-10-01
End date: 2023-12-31
Duration (months): 39.0
Total project cost (EUR): 883502.5
EU funding (EUR): 883502.5
Participants: 6
Project status: SIGNED

University of Kragujevac (UKG), Serbia and specifically the group of Prof. Nenad Filipovic is a research group active in the field of multiscale modeling and medical informatics in biomedical engineering. The group has published numerous studies in scientific journals and has participated in FP7, H2020 and other international RDI projects. Prof. Filipovic spent several years at Harvard University and upon returning to Serbia he founded a strong group of young researchers specialized to perform research in the field of biomedical engineering. Although the group produces significant research results, either as outcomes of collaboration with local medical staff or through EU research projects, the quality of those remains limited and most of the results have been published in journals with low IF. The target of the TWINNING action SGABU is to enhance research capacity and capabilities of UKG, through collaboration with four EU leading research institutions - University of Ioannina, Greece; Vienna University of Technology, Austria; Katholieke Universiteit Leuven, Belgium and Newcastle University, the UK. These four universities are widely recognized in producing high quality research results and are very active in performing research in the field of multiscale modelling and medical informatics in biomedical engineering. Exchange of know-how and scientific experience between UKG and the EU partners will be accomplished through meetings at UKG at the partner institutions; study visits of staff members to the partner institutions and their labs; summer school, workshops. One of the main project results will be a computational platform for multiscale modelling in biomedical engineering which will be integrated, tested and validated on the patients with cardiovascular, bone and cancer disease.

Keywords: multiscale modelling,medical informatics,biomedical engineering,cardiovascular,bone,cancer,disease,tissue engineering
Reputation Matters in the Regulatory State: Re-thinking the Fundamentals of Regulatory Independence, Credibility and Accountability (RICA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands,Netherlands,United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-06-01
End date: 2023-05-31
Duration (months): 72.0
Total project cost (EUR): 1444852.0
EU funding (EUR): 338266.5
Participants: 3
Project status: SIGNED

RICA will fundamentally challenge, reconceptualise and redefine core foundational assumptions of the regulatory state. Arm’s length governance and regulatory independence have become the cornerstone normative and institutional design principles of the European regulatory state. Regulatory credibility is premised on agency insulation from politics with major systemic implications in the form of a rise in non-majoritarianism and a parallel devaluation of the political process. Efforts to compensate through alternative sources of input legitimacy have proven challenging. Conceptualised in a rational-choice tradition, accountability is seen to be in a zero-sum relationship with regulatory autonomy. Bolstering accountability is said to threaten autonomy, undermining the system’s normative foundations. Informed by insights from the political science literature on reputation, RICA profoundly questions these assumptions. It does so in two separate and interlocking tracks. Module 1 theorises about, and tests, the established wisdom of a wholesale positive relation between agency insulation and credibility. To the contrary, from a reputational perspective, a strategy of insulation is expected to have a negative effect on regulatory credibility, with overall delegitimising effects. Similarly informed by reputation insights, Module 2 challenges dominant understandings of accountability and puts forward the building blocks of a new theory of public accountability. The module draws out and studies empirically how reputation shapes the accountability behaviour of regulatory actors, both account-holders and account-givers, and their interactions. It will re-conceptualise the role played by accountability in the regulatory state as well as its relationship with autonomy. In contrast to dominant understandings, as a mechanism of reputation-building, accountability can reinforce autonomy with sweeping implications for regulatory control strategies and institutional design choices.

Keywords: regulation,agencies,accountability,independence,reputation,control,agencification,credible commitment,regulatory credibility,regulatory state,voluntary accountability
Mechanically-Interlocked Ring-on-Thread Molecules for Super-Resolution Imaging (Ring-STORM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-15
End date: 2020-10-14
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

This interdisciplinary project focuses on the development of unprecedented autonomous novel photoactive nanoscopic molecular machines that “blink” for fluorescence microscopy imaging with a resolution higher than the light scattering limit. Its use in super-resolution imaging will represent a major innovation in imaging, both conceptually and practically, overcoming many inherent constraints associated with current techniques. By applying steady-state and time-resolved spectroscopies, photo-induced electron transfer will be used in these autonomous [2]rotaxanes to modulate fluorescence, and studies down to the single-molecule level (based on Stochastic Optical Reconstruction Microscopy) will be undertaken to achieve a new localization microscopy method ("Ring-STORM") adapted for living cells, without the need for overexpressing genetically encoded fluorescent proteins. The project will be developed at leading French research institutes, Institut des Sciences Moléculaires (ISM) and Institut d'Optique (LP2N-IOGS) both at the CNRS/Univ. Bordeaux. The fellow, a specialist in synthetic organic and supramolecular chemistry from Spain, will receive via the project training in molecular photochemistry/photophysics and super-resolution fluorescence imaging, providing him the necessary skills to design, develop and study novel tailored-made functional supramolecular architectures with enhanced spectroscopic properties. For this, the project is organized in synergistic work packages to assure efficient coordination and management, career development and training, science development, communication and technology transfer by patenting the new super-resolution imaging methodology that Ring-STORM expects to develop. This will give him independence and professional maturity towards an independent research career. The experience of the fellow, the expertise of the research groups, the infrastructure and equipment will assure the fulfilment of the project objectives.

Keywords: super resolution imaging,fluorescence,molecular machines