Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
VALidation tests of ElectroMechanical Actuators and its dedicated control units at TRL 6 level (VALEMA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Spain,Spain,Spain
Call: Validation tests of electromechanical actuators and its dedicated control units at TRL 6 level (H2020-CS2-CFP04-2016-02, 2016)
Start date: 2017-06-01
End date: 2022-07-31
Duration (months): 62.0
Total project cost (EUR): 1091512.5
EU funding (EUR): 782512.5
Participants: 5
Project status: SIGNED

The objective of the VALEMA project is twofold: - On the one hand it is required to manufacture and assembly units (EMAs and ECUs) previously designed and developed according to the JTI-CS2-2016-CFP03-SYS-02-14 Call (Development of electromechanical actuators and electronic control units for flight control systems) for in flight tests activities. - On the other hand it is required to perform certification activities regarding both the HW and SW of the ECUs in order to obtain a permit to fly in the FTB2 demonstrator of the Regional Aircraft. The manufacturing part will include a deep analysis of manufacturing routes, materials to be used and applicable qualification tests, searching for innovative processes, in order to ensure that the processes optimize the manufacturing time, minimize the raw material used and minimize the environmental impact. The certification activities will be aimed at obtaining the permit to fly from the applicable Airworthiness Authorities for the aileron/spoiler ECU HW design (according to DO-254) and for the aileron/spoiler ECU SW design (according to DO-178B). These activities can be considered as the last step within the HW and SW design of the aileron/spoiler ECU development to be undertaken in EMA4FLIGHT according to the JTI-CS2-2016-CFP03-SYS-02-14 Call and, as such, the innovations developed within that call also apply herein.

Keywords: permit to flight
engineering ligand-REceptor INteractions FOR Molecular communicATIONs (REINFORMATION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Türkiye
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-12-01
End date: 2023-11-30
Duration (months): 24.0
Total project cost (EUR): 145355.52
EU funding (EUR): 145355.52
Participants: 1
Project status: SIGNED

Molecular Communications (MC) is the nature’s way of networking at nanoscale, observed in almost all biological systems, including bacterial populations and nervous system. MC has been widely studied to enable the networks of artificial nanoscale devices promoting new high-impact applications such as intrabody continuous health monitoring with mobile nanosensor networks. At the core of the natural MC systems lies the ligand-receptor (LR) binding interactions, which provide the selectivity of information transfer. Likewise, LR interactions are essential for artificial MC systems to have a selective and reliable channel/receiver interface in the form of a biorecognition layer consisting of ligand receptors. Recent studies have revealed the dramatic impact of LR interactions on the overall MC performance in terms of channel bandwidth, molecular interference, receiver sensitivity and dynamic range, posing a multi-objective optimisation problem. The aim of REINFORMATION is to understand, optimise and engineer the LR interactions for high data-rate and reliable MC systems. To this end, the project will first deliver a realistic theoretical modelling and optimisation framework for MC accompanied by a microfluidic experimental test and validation platform with graphene aptasensor-based MC receivers. The framework will provide the first experimentally validated micro/nanoscale MC models, and enable the optimisation of binding affinity and kinetic rates of LR interactions from the MC perspective. The optimisation results will guide the rational design of new aptamer receptors for target information-carrying proteins, which will then be implemented on the experimental platform. The project will finally provide novel MC modulation and detection techniques, exploiting the LR interactions for high data-rate and reliable MC. Combining expertise in MC, nanotechnology, and computational biology, the project will remove a major barrier to the development of practical MC applications.

Keywords: molecular communications,nanonetworks,nanoscale communications,biosensors,nanosensors,microfluidics,receiver,ligand receptor interactions,detection,modulation,internet of bio nano things
Learning from the past: linking ancestral epigenetic states to current cellular fates with single-cell multi-omic approaches (FateID)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The establishment of cell type-specific transcriptional programs involves many interconnected regulatory mechanisms acting on different genomic scales. To dissect this multi-layered control of gene expression in detail, I will develop methods that a) measure multiple cellular outputs in single cells, and b) obtain that information in a time-resolved manner. This proposal outlines my approach to study early mouse development at numerous levels, including (but not limited to) transcription, chromatin context, and nuclear organization. In doing so, I expect to shed light on the mechanism behind cell fate specification and the epigenetic states that precede it. I will develop a novel strategy to simultaneously profile many factors involved in gene regulation in the same cell. Its successful implementation will give insight into transcriptional control at unprecedented modality, revealing the causal relationships between histone modifications, spatial positioning within the nucleus, Polycomb group proteins, and others. Next, I will pursue several “molecular memory” strategies to obtain recordings of past regulatory states, followed by multi-omic readouts at later developmental times. Such retrospective analyses enable linking fate decisions to past molecular events in the same cell, thereby permitting careful reconstruction of the molecular trajectories underlying cell fate choice. Finally, these and previously developed single-cell methods will be applied to unravel the gene-regulatory mechanisms that govern lineage determination in early mouse development.

Keywords: spatial genome organisation,single cell genomics,epigenetic,nuclear lamina
The Finances of the Caliphate: Abbasid Fiscal Practice in Islamic Late Antiquity (CALIPHALFINANCES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1497647.0
EU funding (EUR): 1497647.0
Participants: 1
Project status: SIGNED

This project offers an ambitious new account of a seminal period in Islamic history. It will for the first time provide a view from below on Abbasid fiscal history through a study of papyrus documents in Greek, Coptic and Arabic written in Egypt, a field in which the PI is a leading scholar. The Abbasids were the second longest ruling dynasty in Islamic history (750-1258). The first centuries of their rise to power are of key importance for the history of Islam, as the earliest surviving literary texts written by Muslims (religious, legal and fiscal treatises, grammars and poetry) were composed at this time and in their capital, Baghdad. They have been the preferred sources for scholars working on this period. As a result, our current view of Abbasid state structures is a view from the top. State policies, however, were not decided by the caliphal centre and Baghdadi administrators alone. CALIPHAL FINANCES will refocus scholarship on the totality of Abbasid administration. It will be the first large-scale research project on Abbasid administrative and fiscal history to make use primarily of documentary sources. Egyptian papyri are concerned with everyday arrangements for fiscal collection in secondary urban centres and villages of the Nile valley. Capitalising on this material, the project will study the organisation of tax collection, tax rates and categories of taxpayers. The project team will trace how provincial revenues reached the caliph, incorporating information found in provincial chronicles with that in the papyri. Connections between administrators and local elites, religious and linguistic communities, their convergence on fiscal questions, their loyalty or resistance to the caliphate will all be assessed. In a field largely dominated by religious history, CALIPHAL FINANCES will renew our understanding of the dynamics of change in pre-modern state structures, with a focus on the complexity of local agency.

Keywords: fiscal history,state structures,administration,multilingualism,abbasid,empire,late antiquity
On- and offline-Networks for Event Aware Topological detection (O-NEAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2021-01-01
End date: 2022-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Imaging methods enabling the acquisition of millions of cell contours have opened the path for improved understanding of development, repair, homeostasis and pathology. The full potential of such imaging methods can only be reached when robust, cost-effective and user-friendly methods are democratized to extract important information from the huge amounts of data generated. Our project aims to implement a disruptive deep-learning based technology, O-NEAT, that uses these masses of data for training neural networks to automatically and reproducibly explore tissue dynamics. This would enable researchers in academia and the private sector to quickly and reliably extract information regarding cell dynamics in normal or pathological conditions thus having significant potential market applications.

Keywords: live imaging,image analysis,software,deep learning,artificial intelligence microscopy
GUideline Implementation with DEcision Support systems (GUIDES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-15
End date: 2017-07-14
Duration (months): 24.0
Total project cost (EUR): 208400.4
EU funding (EUR): 208400.4
Participants: 2
Project status: CLOSED

Healthcare based on the best available clinical evidence can lead to better quality of care. Evidence-based guidelines are potentially important instruments, but clinicians often do not adhere to them. A computerised decision support system (CDSS) is a technology that uses patient-specific data to provide relevant medical knowledge at the point-of-care. It is considered to be an important quality improvement intervention and EU member states are recommended to prioritise investment in it. However, the significant investments do not consistently result in value for money due to content and implementation issues.This project aims to improve the impact of CDSS through better content wise development and optimised implementation. Our objectives are to (1) investigate the factors that determine successful CDSS implementation, (2) develop tools to address these factors and (3) validate the utility of these tools through the development of a tailored CDSS intervention. We also (4) develop a protocol for a cluster randomised controlled trial on the effectiveness of the tailored CDSS intervention. We selected the conservative management of knee osteoarthritis as a prototype condition for the pilot. Ultimately, the better implementation of CDSS may lead to better informed decisions and improved care and patient outcomes for a wide range of conditions. This project integrates expertise from multiple scientific domains and builds upon the leading expertise from the consortium in major projects (GRADE, DECIDE, TICD). The planned research and training will lead the fellow to an essential new specialist role for the successful implementation of CDSS and will be the start of an international multidisciplinary career. The project is a response to the Horizon 2020 health priorities on transferring knowledge to clinical practice, individual empowerment for self-management of health, scalable innovation actions, better use of health data, treating chronic diseases, and active ageing.

Keywords: chronic disease,decision support systems,patient participation,quality improvement
The Quantum Structure of Black Holes and the Recovery of Information (QBH Structure)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-01-01
End date: 2024-09-30
Duration (months): 69.0
Total project cost (EUR): 2462659.0
EU funding (EUR): 2462659.0
Participants: 1
Project status: SIGNED

The detection of black-hole mergers in 2015 was a spectacular confirmation of General Relativity (GR). Yet, it is also in black holes that the fundamental conflict between GR and quantum mechanics (QM) is most acute. Black holes are known to have a vast entropy. Consistency with QM requires that the microstates giving rise to this entropy must be accessible at the horizon scale. However, GR coupled to field theory is incapable of supporting this horizon-scale microstructure! My work has shown that Microstate Geometries (MG’s), based in string theory and higher-dimensional field theory, have all the essential elements for supporting and encoding microstate data: MG’s are smooth, horizonless solutions in string theory that are identical to black holes on large scales but differ radically from the black holes of GR at the horizon scale. I propose to launch a new, extensive study of the MG paradigm, focussing on the, as yet, unexplored dynamics of the microstructure in MG’s: (i) How infalling matter is absorbed and diffused into excitations of MG’s; (ii) How the excitations of MG’s, and the MG’s themselves, decay into some form of Hawking radiation that carries the microstructure data to infinity, thereby preserving quantum unitarity; (iii) How the large-scale, collective dynamics of microstructure interacts with matter in the horizon region and, particularly, how microstructure dynamics influences accretion disks and black-hole mergers. Progress will be achieved by analyzing the energy transfer between infalling probes and MG’s, computing the resulting excitations of the MG and the drag on infalling objects. The results will be re-expressed in a hydrodynamic form that can be applied to simulations of astrophysical black holes. This proposal will thus solve the information paradox by providing a microscopic description of black-hole entropy at the horizon scale and this should lead to macroscopic, measurable signatures of the horizon-scale microstructure.

Keywords: string theory,black hole information paradox
Portable Characterisation of Sperm Motility (PorCSperM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-04-01
End date: 2018-09-30
Duration (months): 18.0
Total project cost (EUR): 139986.0
EU funding (EUR): 139986.0
Participants: 1
Project status: CLOSED

Based on an ongoing ERC project on characterising and studying the motility of highly-idealised, model micro-swimmers, we have built and validated a first-generation portable prototype device for assaying accurately bull sperm motility. To move to a more advanced prototype requires integrated software and hardware development and the setting up of standard protocols to render the measurement procedure robust for non-expert operators. Such a device, with integrated hardware and software, for Portable Characterisation of Sperm Motility (PorCSperM) will assembled and applied to bull semen in this project, but is in principle applicable to other animals, and perhaps also to human fertility.

Keywords: sperm motility,microorganism motility,bull fertility,differential dynamic microscopy,active matter physics
Support to Reinforce the European Strategy Forum for Research Infrastructures (STR- ESFRI)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Coordination and support actions
Countries involved: Italy,Germany,Greece,United Kingdom
Call: Policy measures for research infrastructures (H2020-INFRASUPP-2014-2, 2014)
Start date: 2015-03-01
End date: 2019-02-28
Duration (months): 48.0
Total project cost (EUR): 1999983.75
EU funding (EUR): 1999983.75
Participants: 5
Project status: CLOSED

A 4 year "Coordination and Support Action" project led by the Science Technology Facilities Council (UK) in partnership with Universita degli Studi di Milano, (Italy), ATHENA Research and Innovation Centre, (Greece) and German Aerospace Center, DLR (Germany). The goal of STR-ESFRI is to provide support to reinforce the European Strategy Forum for Research Infrastructures (ESFRI) under the guidance of its Chair, by providing additional resources, tools and expertise for performing its activities and supporting its structures. The main objectives of this project are to provide support to the ESFRI Chair in all ESFRI related activities, to support the process for delivery of the new ESFRI Roadmap, to disseminate and exploit ESFRI related outputs to the European and Global Research Infrastructure Area, liaise with key stakeholders including the e-Infrastructure Reflection Group (e-IRG), to identify best practices and facilitate the exchange of experiences among ESFRI projects and other European and Global Research Infrastructures and finally to monitor projects on the ESFRI roadmap.

Keywords: esfri,european strategy forum for research infrastructures,str esfri
Understanding how Inositol Polyphosphates regulate autophagy and lipid body formation in photosynthetic organisms: crosstalk with TOR signaling. (INSPirAUTOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-03-01
End date: 2021-02-15
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

The elucidation of regulatory networks that govern cell growth and carbon storage in photosynthetic cells may potentially benefit the world's dependence on the declining reserves of fossil fuels. The growth/carbon sink relationship impacts metabolism, carbon partitioning and productivity but its regulation is poorly understood. Recently, we found a connection between two major cell growth regulators in the model green alga Chlamydomonas reinhardtii. Our findings revealed a synergistic effect between TOR kinase and Inositol polyphosphate (InsP) regulating lipid metabolism and the recycling process of autophagy. Based on the relevance of these results, we aim to find the mechanisms and the conditions in which this intersection takes place within the green lineage. In this sense, we have designed a straight-forward project including different goals. First, we will set novel analytical tools to evaluate the InsP level fluctuations in the presence of new TOR inhibitors and monitor the impact on autophagy flux and lipid metabolism in the model photosynthetic organisms Chlamydomonas reinhardtii and Arabidopsis thaliana. Second, we want to identify the phosphorylation targets of InsPs using Kinome/P-phosphoproteome in a Chlamydomonas InsP-deficient mutant. This analysis will unravel the phosphorylation network of InsP signaling and will provide new insights about the role of InsP in the control of cell growth. Third, we will evaluate InsP levels, autophagy flux and lipid storage under nutritional stress to determine the InsP modulation response in plants and algae. Understanding this signaling pathway will impact metabolic engineering of food and biofuel crops to improve yields of high-value products including oils and lipids. We believe this project will impact a general audience and will help to teach people how basic research can turn into a greater understanding of a process that is conserved in humans and has a direct economic impact.

Keywords: autophagy,tor kinase,inositol polyphosphates,lipid metabolism,chlamydomonas reinhardtii,arabidopsis thaliana,c storage,biofuels,metabolic network