Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecular Spintronics using Isolated Rare Earth Magnets (SpinReMag)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

A revolution is underway, as the fast-paced electronics industry moves towards the nanoscale, researchers are starting to consider single-molecule electronics. Such devices are within reach partly due to a new field, called molecular spintronics, which permits the prospect of controlling both spin and charge in single molecules. On the other hand, we know almost nothing about how a magnetic molecule is affected by electrons flowing through it or what chemical ingredients it takes to construct perspective devices. SpinReMag will investigate these uncharted waters by exploring the boundary between chemistry and single-molecule read-out technology. SpinReMag is a strongly multidisciplinary project utilizing an innovative mix of synthetic chemistry, physics and materials methodology to overcome present experimental limitations. Our design approach is to investigate single-molecule junctions, except instead of placing a molecules between bulk electrodes, we will directly grow photoactive groups on the molecule so that electrons will flow through or close to the spin center after a light pulse. This affords an ultra-clean system that can be studied in bulk, with a perfectly defined geometry of the magnetic and electronic elements. SpinReMag will provide the fundamental ground work to explain how molecular spins interact with flowing electrons. The execution of this project will for the first time provide the understanding of fundamental spintronic processes, and open new pathways to the rational design of single-molecule spintronics. The information gathered by SpinReMag will direct the future of research in single-molecule electronics and in the optical control of spin systems in general.

Keywords: lanthanide,single molecule magnet,electronic transport,single molecule electronics,break junctions
Technology and Innovation for Development of Modular Equipment in Scalable Advanced Life Support Systems for Space Exploration (TIME SCALE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Italy,Belgium,Norway,Belgium,Norway,Netherlands,Netherlands
Call: Space exploration – Life support (H2020-COMPET-2014, 2014)
Start date: 2015-02-01
End date: 2018-04-30
Duration (months): 39.0
Total project cost (EUR): 3871209.36
EU funding (EUR): 3871209.0
Participants: 9
Project status: CLOSED

The TIME SCALE project will bring closed regenerative life support system (CRLSS) to the next level by further development of the European Modular Cultivation System (EMCS). The EMCS has been successfully operated on the International Space Station (ISS) for 7 years with rotors allowing scientific research under Moon and Mars gravity exposures in addition to microgravity conditions. The EMCS modular design provides the possibility to replace the individual subsystems including the entire rotor system. The TIME SCALE project main objective is to develop an EMCS Advanced Life Support System Breadboard (EMCS ALSS BB) and demonstrate the operational capability for the ISS. The EMCS rotor baseplate will provide generic interfaces to several compartments of a CRLSS such as higher plants (crops), algae bioreactors and mouse. Scientific knowledge on whole higher plant (crop) physiology and fundamental processes under Moon and Mars gravity conditions are essential to ensure a safe and reliable food supply in future space exploration and integration of higher plants into a CRLSS. As part of the project an EMCS crop cultivation system will be developed and tested. The closed water and nutrient management research and development will include solution for challenges such as lack of thermal convection and the need of optimised technology (e.g. ion specific sensors) to monitor nutrients available for plants. Remote sensing diagnosis of plant health will be implemented using sensors and imaging techniques and Selected Ion Flow Tube Mass Spectrometry (SIFT-MS). Knowledge and technology on nutrient and water recycling and early warning for crop suboptimal growth conditions has significant terrestrial relevance for greenhouse systems. The TIME SCALE project bring together Universities and SMEs with the state of the art knowledge and experience needed to develop the EMCS ALSS BB for ISS and has the capacity to utilise the gained knowledge and concepts for terrestrial application.

Keywords: research,emcs,fractional gravity,scalable,modular,plants,crop,nutrients,water,monitoring
DevelopIng Genetic medicines for Severe Combined Immunodeficiency (SCID) (SCIDNET)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Italy,Germany,Switzerland,France,France,Netherlands,United Kingdom,United Kingdom
Call: New therapies for rare diseases (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 7474316.0
EU funding (EUR): 6926313.0
Participants: 12
Project status: CLOSED

Severe combined immunodeficiency (SCID) is a devastating rare disorder of immune system development. Affected infants are born without functional immune systems and die within the first year of life unless effective treatment is given. Treatment options are limited to allogeneic haematopoietic stem cell transplantation and autologous stem cell gene therapy. Over the last 15 years, gene therapy for two forms of SCID (SCID-X1 and ADA SCID) has shown significant safety and efficacy in correcting the immunodeficiency and allowing children to live normal lives. Proof of concept of gene therapy for 3 other SCID forms has also been shown by members of the proposed SCIDNET consortium and is ready for translation into clinical trials. We are therefore in a position whereby, over the next 4 years, we can offer gene therapy as a curative option for over 80% of all forms of SCID in Europe. Importantly for 1 of these conditions (ADA SCID) we will undertake clinical trials that will lead to marketing authorisation of the gene therapy product as a licensed medicine. In addition, we will investigate the future technologies that will improve the safety and efficacy of gene therapy for SCID. Our proposal addresses an unmet clinical need in SCID, which is classified as a rare disease according to EU criteria (EC regulation No. 141/2000). The proposal also addresses the need to develop an innovative treatment such as gene therapy from early clinical trials though to a licensed medicinal product through involvement with regulatory agencies and is in keeping with the ambitions of the IRDiRC. The lead ADA SCID programme has Orphan Drug Designation and clinical trial design is assisted by engagement with the European medicines Agency. The ADA SCID trial will act as a paradigm for the development of the technologies and processes that will allow gene therapy for not only SCID, but also other bone marrow disorders, to become authorised genetic medicines in the future.

Keywords: rare diseases,scid,gene therapy,genetic medicines
Adaptive wavefront shaping microscope objective lens (Wavelens)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Greece
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-4, 2020)
Start date: 2021-05-01
End date: 2022-10-31
Duration (months): 18.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

For centuries optical microscopy constitutes one of the most fundamental paradigms in biological and medical imaging, even though significantly challenged by light diffusion in tissue, limiting its applicability to superficial depths. Recent advances though have paved the way for exploiting multiple scattering and the increased optical paths to predetermine light propagation, addressing the depth to resolution limits and significantly improve optical imaging capabilities. The currently running DynAMic project in which WAVELENS is linked to aims at revolutionizing microscopic imaging by breaking the depth-to-resolution ratio offering non-invasive, real time, high resolution, multiparametric in vivo imaging, across length scales, deep in biological complex media. Launching from these technology innovations, WAVELENS aims at substantially disrupting the modus operandi of microscopic imaging creating a next generation microscopy capability with enormous benefits for the scientific, industrial and societal community. What this project will achieve is to investigate the commercialization of a completely new line of technology based on the advanced wavefront shaping systems developed within DynAMic up to the proof of concept level, and further engineered and integrated in the shell of a standard microscope objective lens. Spearheaded by this proof of concept prototype, WAVELENS will produce user-defined demonstrator prototypes, a complete market analysis, IP valuation and freedom to operate landscape, a detailed business plan and complete pitching portfolio, providing a concrete foundation for a high-tech spin-off company created during or after the end of the project.

Keywords: wavefront shaping microscopy,adaptive microscope objective lens
Organic Functionalisation of N2 Using Metal-Main Group and Metal-Metal Cooperativity (OrFuNCo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France,France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2023-08-31
Duration (months): 66.0
Total project cost (EUR): 1499640.0
EU funding (EUR): 1499640.0
Participants: 2
Project status: SIGNED

Activation and transformation of dinitrogen (N2) into other nitrogen-containing compounds is a challenge for chemists due to the inertness of this molecule. The well-established Haber-Bosch process allows transformation of dinitrogen into ammonia (NH3) at the industrial scale through heterogeneous catalysis, but it is an energy-demanding process (1-2% of the World's annual energy consumption). The ammonia thus produced is almost totally converted into more value-added chemicals. Similarly, in Nature, the nitrogenase enzymes are able to convert N2 into NH3 catalytically, spending a high amount of energy to produce a molecule which is subsequently transformed into amino-acids or nucleotides. At a time where energy savings have become a major issue, alternatives to the Haber-Bosch process are desirable. Improving ammonia synthesis still prevails in current dinitrogen chemistry, despite the relative lack of utility of this molecule. Conversely, a catalytic process affording a nitrogen-containing product directly from N2 does not exist yet, and remains a highly attractive, though challenging, goal. Given this context, the PI proposes to investigate novel molecular chemical tools capable of direct conversion of N2 into nitrogen-containing organic compounds under mild conditions, while approaching the catalysis problem from a new direction. Two unprecedented strategies relying on the symbiotic reactivity of two partners towards dinitrogen will be detailed herein. In the first one, metal-boron frustrated Lewis pairs (FLPs) will help activate and functionalise N2, thus unlocking the thus far missing FLP chemistry of this small molecule. In the second one, it is proposed to explore the virgin territory of N2's cycloaddition reactivity, thanks to bimetallic cooperativity. By the careful examination of stoichiometric reactions considered as key steps of putative catalytic cycles, tackling the "Holy Grail" of catalysis will be facilitated.

Keywords: dinitrogen,frustrated lewis pairs,organometallic chemistry,cycloadditions
A groundbreaking smartlock system to increase security and control of entry points (Digital Keys)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

LEAPIN has developed a new type of access control and unlocking system. Digital Keys is a Software Development Kit that utilises apps and web-based software to set, send, receive and revoke time sensitive one-time use passwords (keys) to provide access anytime anywhere. A secure encrypted technology is used to overcome concern related to fear of hacking and security. The traditional magnetic stripe technology is outdated and the system is subject to regular failures. The installation of innovative smartlocks delivers a more reliable and secure system. LEAPIN’s patented technology allows Digital Keys users to open doors with their smartphones, to self check-in to accommodation/assets with their smartphones, to web check-in to their accommodation/assets, to continue to use keycards linked with Near Field Communications and enable complete self-management of accommodation without human interaction. Digital Keys require no supporting network infrastructure through the use of a one-time password cloud based software. The flexibility of remotely controlling and managing access to properties provides convenient accessibility and does not restrict operating hours. Within the overall project, LEAPIN aims to: implement Near Field Communication technology and Bluetooth Low Energy technology features into the LEAPIN Software Development Kit; undertake at least three pilot trials of the smart lock in hotels in 3 EU countries; undertake a market replicability test of the software platform and its functionality; and establish a sound marketing and commercialization strategy.

Keywords: smartlock,near field communications,smartphone,one time password,online check in
Optimal design of frustrated self assembly building blocks (OPT-ASSEMBLY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Romania
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 141778.56
EU funding (EUR): 141778.56
Participants: 1
Project status: SIGNED

Nature's ability to organize building blocks into large structures of finite size has inspired many researchers to attempt similar constructs with synthetic subunits. DNA origami triangles are such synthetically built subunits capable to self assemble to shells of various shapes. Subunits and their interactions are typically designed so that they match the target shell geometry as much as possible. Such designs, however, require an increasing number of subunit types as the target shell complexity increases. Instead, we propose a computational scheme aimed to reduce the required subunit specificity in such assemblies, by relaxing the exact geometrical constraints on the target surface and exploiting subunit deformability. Two example structures will be considered, in both of which subunits are triangular and the assembly is stress mediated. The first one is an icosahedral structure of either of two sizes, both in a mechanically stressed state. Our aim is to find the appropriate subunit design which assembles both sizes with prescribed yields, from a single type of subunits, by adjusting the subunit's mechanical properties. The second structure is an ellipsoidal shell, which, again, we aim to assemble from a single species of subunits. Finite compliance allows subunits to adapt to the local geometry and coordination, however, the associated frustration raises the problem of controling long range elastic interactions and rules out naive subunit designs. As a solution, we propose an optimization approach to efficiently adjust the subunits' mechanical properties until a target free energy minimum is reached at the required sizes and shapes. We use a coarse grained triangle model with a grand canonical Monte Carlo scheme for equilibrium and dynamical simulations. Progressing from the fastest towards the most accurate estimates of the free energy we intend to provide a full stack methodology for finding the most optimal subunit parameters given a target structure.

Keywords: self assembly,self organization,dna origami,elastic shells,monte carlo simulations
DRone European AIM Study (DREAMS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Italy,Spain,Italy,Italy,Netherlands
Call: Drone information management (H2020-SESAR-2016-1, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 710435.0
EU funding (EUR): 710435.0
Participants: 6
Project status: CLOSED

The DREAMS project aims at contributing to the definition of the European UTM Aeronautical Information Management operational concept by exploring need for and feasibility of new processes, services and solutions for the drone aeronautical information management within the new UTM concept. The UTM is seen as the key enabling concept for safe integration of drones within VLL airspace, tailored on the needs of UAS operations. The study put together the knowledge of mission needs and operational requirements of drones commercial operators that want to make their operations safer and cost effective (BVLOS) with the knowledge of operating modes and procedures currently adopted by airlines and aircrew, general aviation associations and pilots, leisure/sport aeronautical activity associations and pilots, accessed information services, required data quality, resolution, temporality and services costs. The study will be focused not only to the needs of drones operators but will addressed the aeronautical information sharing requirements coming from the several stakeholders involved for different purposes in the drones VLL operation concept. The DREAMS study and its methodology are based on a deep competence in systems and technologies, currently used in the management of all types of air traffics, for flight planning, static and dynamic aeronautical Information and for airspace design and management. Operational and technical aspects, environmental scenarios, technologies, safety and security impact will be analysed in order to identify possible UTM data service providers (e.g. airspace structure, terrain, obstacles and weather,..) and facilities and the way this data service need to be tailored for UTM management service provision in order to allow quality and resilient information and airspace services.

Keywords: information sharing,no fly zones,swim,bvlos,vlos,autonomous flight
Preclinical Human In Vitro Drug Immune Response Analysis Platform (PHIVIDIAS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-01-01
End date: 2019-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Drug-induced tissue damage and the associated risk for developing auto-immune secondary disease is fully ignored in preclinical toxicity testing. As a consequence, there are currently 300 drugs on the market that cause drug-induced auto-immune-mediated interstitial lung disease. In their regulatory documents, EMA and FDA strongly advocate for inclusion of tests to address this type of adverse effects in preclinical research. Immundz (www.immundnz.com) addresses this market opportunity by developing a unique and innovative platform, PHIVIDIAS, for comprehensive preclinical analysis of drug-induced tissue damage and the immune response against molecules released from the damaged cells, together with a computational model for risk assessment for developing auto-immune secondary disease. The testing platform will be animal free. Key persons from the client networks and a variety of other small and large companies have already been approached to assess their interest in the PHIVIDIAS platform. Their feedback identified a significant need for the PHIVIDIAS test platform and a variety of companies expressed their commitment to use the services. With PHIVIDIAS, Immundnz will be first in the market.

Keywords: in vitro,preclinical,immunology,immune response,auto immunity,cell culture,immune modelling,tissue damage,secondary disease,immunogenicity,predictive model,drug induced