Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Metallolinker-Functionalized MOF Catalysts for CO2 Hydrogenation (TUNEMOF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Norway,Denmark,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-15
End date: 2025-02-14
Duration (months): 30.0
Total project cost (EUR): 263638.8
EU funding (EUR): 263638.8
Participants: 3
Project status: CLOSED

One of the main challenges of the 21st century is the reduction of CO2 emissions to the atmosphere, for which replacing fossil fuels with renewable energy sources will help. Methanol is a sustainable key compound that can be directly used as a low-density fuel or as a feedstock for valuable platform chemicals. To date, efforts to perform CO2 hydrogenation to methanol under mild reaction conditions have not achieved high enough selectivity at reasonable conversion values. Heterogeneous catalysts are robust and easy to recover but usually yield low selectivity due to the difficult control of the active sites during synthesis. In contrast, homogeneous catalysts feature well-defined active sites amenable to logical optimization and selectivity design, but inefficient catalyst recovery and decomposition are huge shortcomings for industrial implementation. TUNEMOF proposes to overcome these drawbacks by developing metallolinker-functionalized MOFs bearing earth-abundant metals (Fe and Mn). The immobilization of the molecular-based catalyst center will promote the metal-ligand cooperation and the secondary linker assistance will prevent the deactivation of the catalyst. Meeting this strategy with low-cost metal-based catalysts is a significant added value. TUNEMOF integrates the experience of the researcher in organometallic chemistry, the excellence of Prof. Olsbye’s group (University of Oslo) in applied chemistry of porous materials, the experience in catalytic testing of homogeneous systems of Prof. Beller (LIKAT, secondment), and in spectroscopic analysis and techno-economic assessment of Haldor Topsøe (non-academic placement). This synergy provides a unique networking platform to diversify the researcher’s individual competences and to promote the interdisciplinary and inter-sectorial transfer of knowledge. The complete training gained from the development of TUNEMOF will promote the professional career of the applicant to become a leading independent researcher.

Keywords: metal organic frameworks,co2 hydrogenation
The Formal Turn - The Emergence of Formalism in Twentieth-Century Thought (FORMALISM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1987840.0
EU funding (EUR): 1987840.0
Participants: 1
Project status: SIGNED

The philosophy of science and logic underwent a wide-ranging formal turn in the first half of the twentieth century. This shift is characterized by a new emphasis on formal methods and the adoption of a general formalist viewpoint towards the disciplines in question. The project will give a first interdisciplinary and comparative study of early contributions to formalism in twentieth-century thought. This general objective will be addressed in terms of three interrelated subprojects. The first subproject is historical in character and aims at a historical reconstruction of the emergence of formalist thinking in nineteenth-century mathematics and neo-Kantian epistemology. On the mathematical side, the project will retrace several methodological developments in geometry and algebra between 1860 and 1910 that contributed to a formalist conception of these fields. Regarding its philosophical roots, the focus will be on contributions to a formalist notion of scientific objectivity in the work of the Marburg school of neo-Kantianism (Hermann Cohen, Ernst Cassirer, Paul Natorp). The second subproject will give a comparative study of the formal turn in logic and logical empiricism between 1920 and 1940. This includes research on the foundations of mathematics and the formality of logic by members of the Göttingen school (David Hilbert, Paul Bernays, Gerhard Gentzen) as well as central contributions to a scientific formalism in logical empiricism (Rudolf Carnap, Moritz Schlick). The third subproject will analyze the philosophical implications of the formal turn for the subsequent shaping of these fields. The emergence of formalist thinking was closely related to the development of new theories of semantics in logic and philosophy. The aim will therefore be to connect the early contributions to formalism with contemporary debates on the philosophy of model theory and inferentialism as well as with the logical study of scientific theories.

Keywords: history of formalism,logical empiricism,philosophy of science,history of modern logic,philosophy of mathematics
Response of the Earth System to overshoot, Climate neUtrality and negative Emissions (RESCUE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Netherlands,Italy,Norway,France,Austria,Denmark,Switzerland,Sweden,South Africa
Call: Improved understanding of greenhouse gas fluxes and radiative forcers, including carbon dioxide removal technologies (HORIZON-CL5-2021-D1-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 7999427.5
EU funding (EUR): 7999426.0
Participants: 18
Project status: SIGNED

The RESCUE project will improve knowledge and understanding in area c) of this call: “Climate and Earth System responses to climate neutrality and net negative emissions”, by pursuing two overall objectives: 1) Quantify the climate and Earth system responses to pathways achieving climate neutrality by Carbon Dioxide Removal (CDR) deployment with and without temperature overshoot, and 2) Assess the potential role of CDR in reducing net GHG emissions, as well as its potential environmental risks and co-benefits. RESCUE will expand existing knowledge on CDR methods, to design a suite of new global temperature stabilization scenarios at several target values to achieve the first objective. New model developments will deliver improved climate projections with explicit representation of CDR portfolios for these scenarios. The analyses will be devoted to finding suitable pathways to climate neutrality considering multiple aspects of the Earth system response: mean climate and extremes, sea-level rise, global carbon cycling, biodiversity, and ecosystem services. Particular attention will be paid to the reversibility of induced changes by comparing scenarios with and without temperature overshoot. The second objective will be achieved by analyses assessing various factors determining overall effectiveness, impacts and co-benefits of CDR portfolios. These factors include CDR-specific CO2 uptake, CDR-induced biogeophysical climate feedbacks, CDR-derived non-CO2 radiative forcers, and the interaction between socio-economic and environmental impacts (e.g., biodiversity). Moreover, a dedicated analysis will provide key criteria for developing a monitoring system for the effectiveness of CDR portfolio deployments and their potential side effects. Stakeholders will be closely engaged throughout the project to ensure policy relevance and final update of the results which will be made freely available via existing climate services.

Keywords: earth system climate neutrality carbon dioxide removal temperature stabilization overshoot extreme events environmental impacts climate feedbacks ecosystems cdr effectiveness
New crisis and old mysteries: Resolving cosmic tensions to reveal the dark sector (NewRecords)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

It has recently been established that the current expansion rate of the universe (i.e, the Hubble constant) as measured by local probes is discrepant at 5σ with that predicted in the standard Λ cold dark matter (ΛCDM) model calibrated onto cosmic microwave background (CMB) data. Additionally, analyses of the latest galaxy weak lensing surveys find an amplitude of density fluctuations on large scales (the S8 parameter) that is about 2−3σ lower than what is predicted in ΛCDM. This growing “crisis” is potentially the first indication of a departure from the ΛCDM model, giving hopes to access the fundamental properties of the mysterious dark matter and dark energy that pervade the universe. On the one hand, I have shown with my colleagues that the “Hubble tension” could indicate the presence of new physics in the era pre-recombination, potentially connected to new dark energy properties at early time. On the other hand, the “S8 tension” can be connected to new dark matter properties, and in particular could indicate that dark matter is not stable on cosmological timescales, or interacts with some new light species. Yet, none of the suggested models have been robustly detected nor are they able to explain simultaneously the Hubble and S8 tensions. With the support of the ERC, I will build a group that will develop public tools to firmly identify the new physics mechanism required to explain these cosmic tensions, assess the observational consequences for a wide variety of observables, and the implications for the nature of dark matter and dark energy.
Inhibitor-Mediated Programming of Glycoforms (IMProGlyco)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: United Kingdom,Austria,Norway,Ireland
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-02-01
End date: 2028-01-31
Duration (months): 36.0
Total project cost (EUR): 2998878.0
EU funding (EUR): 2998878.0
Participants: 7
Project status: SIGNED

Site-directed mutagenesis revolutionised the study of proteins and enabled the development of protein-based therapeutics. Our long-term vision is to have equivalent impact through the precise manipulation of the glycans (carbohydrates) on cells and recombinant proteins that will enable the discovery and production of the next generation of therapies for cancer, neurodegeneration and other disease families. The glycans that are present on most proteins and cells have a substantial impact on their biological functions, yet the untemplated nature of their synthesis leads to inherent heterogeneity in both their structure and activity. This heterogeneity is very difficult to control, making it impossible to generate defined glycan ensembles with optimal activity using current technology. Here we present a radically new approach to the controlled manipulation of glycans that will be the functional equivalent of site-directed mutagenesis for manipulating proteins. We will use the delivery of computationally defined mixtures of enzyme-specific inhibitors to the site of glycan biosynthesis in the cell to tune the activity of glycosyltransferases. Our approach, termed Inhibitor-Mediated Programming of Glycoforms (IMProGlyco) will provide an effective strategy to manipulate the glycosylation machinery and thereby generate proteins with defined ensembles of glycans. It will enable the production of precision glycan engineered therapeutic proteins and vaccines. Moreover, shaping cellular glycan profiles will aid discovery science to uncover glycan functions and improve therapeutic cells, such as those used in Chimeric Antigen Receptors cell Therapy (CAR-T). Our technology will be adaptable and expandable into other cell types and organisms allowing glycan shaping in all areas of eukaryotic cell biology to enable new biotechnological applications and fundamental studies of biology.

Keywords: glycosylation,cell culture,biopharmaceuticals,therapeutic cells
BOOSTING INGENIUM FOR EXCELLENCE (BI4E)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Romania,Spain,Germany,Italy,Bulgaria,France,Ireland,Sweden
Call: Capacity building to strengthen networks of higher education institutions and cooperation with surrounding ecosystems (HORIZON-WIDERA-2021-ACCESS-05, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 1998758.0
EU funding (EUR): 1998758.0
Participants: 20
Project status: SIGNED

The BI4E project is born out from the IngEniUm Alliance of European Universities with the ambition of enhancing the existing inter-university cooperation between the partner Universities, as well as with other entities (both international and local), and to strengthen the Higher Education Institutions (HEIs) capacity to meet the diverse challenges faced by the Higher Education System and Institutions: the twin green and digital transition, the fight against climate change, the achievement of the Agenda 2030 SDGs, all of them profound societal challenges the Universities must be ready to address. The BI4E project intends to give a boost to the Alliance, making it an effective instrument to promote excellence in the partner HEIs, particularly targeted to the alliance members in the widening countries, the Gheorghe Asachi Technical University of Iasi and the Medical University – Sofia, and involving leading HEIs from six different Member States. This BI4E project is particularly focusing on the research and innovation missions, completing the strategic and operational capacities of the partners, especially those from the widening countries. BI4E activities will directly touch six out of the seven “transformation modules” proposed by the Policy Report ‘Towards a 2030 Vision on the Future of Universities in Europe’. The project will improve HEI capacity to address major challenges, through the implementation of strategic planning adapted to their needs, institutional transformation, cooperation in terms of research, fostering entrepreneurship and the promotion of international scientific careers. The project will help to build closer cooperation links between the partners that will facilitate the exchange of information, knowledge and experience. At the end of the project the Alliance will be much more prepared to become a fully operational European University Alliance, in which cooperation in education and research will be carried out seamlessly.

Keywords: strategic planning,institutional transformation,cooperation in research,knowledge transfer,talent attraction,entrepreneurship
Tissue-specific induction of autophagy as an innovative therapeutic strategy in cardiovascular and metabolic disease. (CARDIOPHAGY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: CLOSED

Western-style diets are hypercaloric and characterized by high fat and high sugar content. They are responsible for an epidemic of cardiovascular disease, including atherosclerosis (AS), and metabolic disorders, including Non-Alcoholic Fatty Liver Disease (NAFLD). The European population is becoming increasingly exposed to these disorders, for which the only available therapeutic option is lifestyle modification. This typically involves dietary changes and physical activity, but patient compliance with these measures tends to be suboptimal. Pharmacological treatment options could therefore have significant potential to improve patient perspectives. With this respect, pharmacological induction of autophagy is intensively studied. Autophagy is the main detoxification and recycling mechanism of cells, and it has been shown to become dysfunctional in AS and NAFLD. Small molecules that can stimulate the process have been demonstrated to treat the diseases in animal models. However, all known autophagy-inducing molecules lack specificity, and this is suspected to cause systemic toxicity during chronic application in humans. In this proposal, we deliver molecules that avoid systemic exposure by targeting them specifically to disease-relevant tissues. First, potent autophagy inducers will be chemically linked to selected ‘homing peptides’ that we hypothesize to deliver the molecules to dysfunctional vascular endothelial cells in atherosclerosis. Similarly, we hypothesize that triantennary N-acetyl galactosamine (GN3) can guide autophagy inducers to liver cells in the context of NAFLD. All molecules that are prepared in this project will be first studied in cells: both autophagy induction potential and tissue targeting will be evaluated thoroughly. For the best molecule prepared (either endothelial- or liver-targeted), in vivo proof-of-concept will be delivered. In this way, the proposal's potential to deliver new, relevant drugs will be maximally valorized.

Keywords: autophagy,cardiovascular diseases,nafld,tissue targeted,gn3,hepatocytes,endothelium cells,peptide synthesis,
Nonlinear Evolutions and Iterative Algorithms: Optimization and Control (NEITALG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2086498.0
EU funding (EUR): 2086498.0
Participants: 1
Project status: SIGNED

Iterative algorithms (IA) stand as the very backbone of scientific computing. Traditional IA rely on convex optimization to guide the search for optima, severely limiting their scope to local solutions. Consequently, nonconvex problems are regarded as the ultimate challenge of global optimization. Solving them with convergence guarantees will lead to numerous scientific discoveries, such as finding new medications through optimization of the properties of molecules or enhancing materials for solar cells to accelerate advances in green technologies. The first goal of NEITALG is to design new, efficient, and scalable iterative algorithms that can provably solve relevant nonsmooth nonconvex optimizations. This will allow us to overcome locality barriers and open up an entirely new field in scientific computing. Furthermore, parametric IA, which are tailored to training data —making them learnable IA— are currently driving remarkable advances in computing and machine learning. However, most of these systems lack rigorous guarantees of performance or interpretability of results. The second goal of NEITALG is to formulate new learnable IA with focus on interpretability and generalization guarantees. This will greatly advance the development of safer and more reliable technologies based on machine learning. The key approach to achieve both goals involves the systematic study of the largely unexplored mathematical field connecting iterative algorithms and nonlinear evolutions (NE). NEITALG will 1. Explore the principles for which the analysis of NE provides insights into the convergence of an IA; 2. Generate new IA from nonstandard NE to overcome traditional limitations (e.g., locality, lack of interpretability); 3. Provide mean-field optimal control theories for new learnable IA; 4. Obtain guarantees for learnable IA on metric spaces; 5. Develop code and conduct numerical experiments for novel solvers for nonlinear ODE/PDE and new methods for 3D computer vision.

Keywords: iterative algorithms,nonlinear evolutions,global optimization,optimal transport,mean field optimal control,scientific computing,machine learning
Energy Level Engineering of Basal plane of Metal Dichalcogenides (MoSe2 and WSe2) by Doping of Transition-Metals for the Fabrication of Energy storage Devices (POWER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland,Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-08-01
End date: 2025-08-31
Duration (months): 25.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 2
Project status: CLOSED

In POWER, a novel asymmetric supercapacitor (SC) will be fabricated using two-dimensional (2D) transition metal (TM) doped dichalcogenides, with the aim of developing the next generation of high energy and power density SCs as energy storage devices. For the first time, TM (Fe, Co, Ni, Mn, and Zn) doped 2D MoSe2, and WSe2 will be used to fabricate the asymmetric SC and combined with a battery to form a hybrid. This is a timely proposal as the energy-hungry world demands more energy and this growing demand for electrical power requires sustainable energy conversion and storage systems. This is aligned directly with the EU’s Energy Storage and Development roadmap up to 2030. The TM doped MoSe2 and WSe2 will be synthesised using low temperature hydrothermal approaches, and then mixed with binders, and used to form the negative electrode. A commercial activated carbon electrode will be used as the positive electrode, to give the asymmetric SC. The modified electrodes will be characterised using high resolution surface analytical techniques and electrochemical methods. The performance of the fabricated SCs will then be assessed and the potential applications of the optimised SC, considering both the TMs and dichalcogenides, will be explored. By working on POWER, the fellow will have the opportunity to focus on a multidisciplinary project, encompassing Physical Chemistry, Physics, Materials, Electrochemistry and Energy with global impact in the energy sector. Through a tailored Career Development Plan with a 3-month secondment at TU Delft, the fellow will be able to establish new research collaborations within Europe and reach her goal of becoming an independent researcher. With communication targeted on various groups and potential end users, the fellow will develop the skills required to communicate with non-experts, including the public, community groups and charities, enriching her academic experience in the non-academic sector.

Keywords: 2d layered materials,metal chalcogenides,defect engineering,supercapacitors,energy storage