Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Numerical Simulation and Design Optimization of a Lower Fuselage Structure with Advanced Integral Stiffening (FUSDESOPT)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Netherlands
Call:  (SP1-JTI-CS-2009-01, 2009)
Start date: 2010-01-01
End date: 2010-06-30
Duration (months): 6.0
Total project cost (EUR): 99635.0
EU funding (EUR): 74726.0
Participants: 1
Project status: CLOSED

This proposal is for the structural analysis and design optimization of the lower fuselage of an aircraft. The objective of the structural optimization is minimum weight and the design constraints fall into two categories; firstly the capability to withstand structural loads with sufficient margins, and secondly constraints relating to the manufacturing methods. The structure to be optimized is a thin-walled metallic structure with stiffening elements (stringers and frames) using three options for the manufacturing technology: 1. Riveted stiffeners (conventional technology), 2. Laser welded integral stiffeners, 3. Load-adapted stiffeners with welded integral knots. The first two options are reference designs to be analyzed and compared with a new proposal based on the third manufacturing technology. Additionally, two types of aluminium alloy will be considered for the weldable options. The work shall be carried out by experienced aerospace engineers at AOES Group BV, a Dutch SME with many years specialist experience in the structural design, analysis and verification of aircraft and spacecraft structures, including FEM-simulation of large components for aircraft fuselage structures. AOES will use design optimization and topology optimization tools in NASTRAN for identifying the preliminary layout and sizing then standard stress and buckling analysis approaches for the accurate simulation of the load-bearing characteristics and detailed mass calculation. For seamless transmission of data and dissemination of results, data can be received or transmitted as engineering drawings, neutral CAD files or CATIA files. AOES also intends to use the resources of its Medialab department to provide attractive 2-D and 3-D rendering of the results of the work performed.

Keywords: finite element analysis,structural optimization,design,integral,weld,weight
Electrical Harness and Wires Analysis and optimiZation (EHWAZ)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Belgium,France
Call:  (SP1-JTI-CS-2009-01, 2009)
Start date: 2010-02-01
End date: 2010-07-31
Duration (months): 6.0
Total project cost (EUR): 398388.0
EU funding (EUR): 199194.0
Participants: 3
Project status: CLOSED

EHWAZ is a professional software solution dedicated to the sizing, analysis and optimization of electrical wire harnesses in aeronautic context. Starting from an electrical harness definition (logical and wire harness CAD-info and equipment definition), the tool checks whether harnesses comply with user-defined business rules. The harness definitions are then used to create a physical electro-thermal model (Modelica and/or C based). These models are used to simulate the transient electro-thermal phenomena in function of A/C missions and the location of the harness in the A/C. Automated post processing build map of heat flow from the harness to its environment (by branch &amp; by A/C zone), and global results for the harness are reported by wire and by branch: weight, temperature, voltage drop, heat flow. Additionally, the electrical simulation allows plotting the current evolution, temperature and the electrical resistance over time and by wire. The voltage drop includes the current path return with respect to the A/C technology (metal, composite or hybrid). The simulation results are linked to and benchmarked with the professional rules (user-defined by integrator and/or supplier). Eventually, an optimization process is included to help the harness designer sizing and selecting the right wire. The optimization technology takes into account the multiple constraints, discrete standard aeronautical wire database. The optimization wants to achieve minimal harness weight &amp; costs versus an electro-thermal safe, reliable &amp; robust harness. The output of the optimization is an XML file describing the optimized harness selection in term of wire type and gauge. Besides wires optimization, the connectors are challenged to find a lighter global harness. The mechanism of professional rules extension associated with the formalism chosen for models creation offers the possibility to further extend the capacity of the tool.

Keywords: electrical wiring harness,thermal and electrical analysis,gauge optimization
Uncertainty principles versus localization properties, function systems for efficient coding schemes (UNLOCX)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Future and emerging technologies
Action type: Collaborative project
Countries involved: Germany,Switzerland,France,Israel,Germany,Austria,Germany,Germany
Call:  (FP7-ICT-2009-C, 2009)
Start date: 2010-09-01
End date: 2013-08-31
Duration (months): 36.0
Total project cost (EUR): 2529751.0
EU funding (EUR): 1958971.0
Participants: 11
Project status: CLOSED

Algorithms in signal and image processing have reached an impressive level of sophistication and computing power still increases at an exponential rate. However, high-tech applications have an ever-increasing demand for even more efficient algorithms, even more powerful computers and new concepts for advancing applications. Starting from a recently discovered gap in the theory of uncertainty principles, this project aims at developing a framework for constructing problem adapted, ultra-efficient algorithms concerning (de-)coding and analyzing/synthesizing signals/images. We expect, that this will allow us to tackle complex applications in life sciences and ultra precise audio signal processing which presently cannot be solved appropriately with existing algorithms on existing computers. The key for developing these algorithms is a representation of signals and images by function systems, which satisfy the following requirements: 1. Optimal localization, 2. Efficient discretization. The theoretical foundation of this approach is based on the definition of suitable localization measures in generalized phase spaces and the construction of minimizing waveforms. These waveforms are then the basic building blocks in discretization schemes. We expect that this approach allows us to shift the limits of the efficiency vs. precision paradigm considerably. The efficiency of an abstract algorithm has to be evaluated in connection with the computer hardware (parallelization, data exchange, storage) used. Accordingly, our proof of principle includes implementations of baseline algorithms as well as of advanced GPU implementations. As final proof of principle we apply these methods for two challenging applications in audio signal design and life sciences (proteomics). The evaluation will be done by our industrial consortium partners together with our advisory board consisting of one SME, one world market leader and two internationally highly recognized scientific experts.

Keywords: uncertainty principle,signal and information theory,image analysis (proteomics,medical imaging,consumer electronics)
Role of the Grhl1 gene in skin cancer. (GRHL1IN SKIN CANCER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-05-01
End date: 2014-04-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Many functions of the Grainyhead-like (Grhl) transcription factors have already been studied in various animal models. So far these studies have been primarily concerned with the roles of such factors in development and wound healing. Now we have new preliminary data indicating that the Grhl factors are potential novel tumor suppressors. We have already established that the Grhl1-deficient mice have increased susceptibility to chemically induced cutaneous tumor development. We have also generated a list of putative targets of GRHL1 regulation, which are known to be involved in cancer. The proposal outlined here aims to further investigate the role of the Grhl1 gene in skin cancer. We plan to characterize the process of tumorigenesis in the Grhl1-null mice in response to chemical carcinogens and UV radiation. We will analyze the proliferation, differentiation and apoptosis in the induced skin of Grhl1-deficient mice and in the Grhl1-null keratinocytes. We will examine the expression of candidate GRHL1 target genes in these contexts and the binding of GRHL1 to its putative target sites. We will profile changes in gene expression during chemically- and UV-induced tumorigenesis in the Grhl1-deficient mice using microarray technology. Our ultimate aim is to unravel the molecular mechanisms underlying the Grhl1 function in skin cancer. The results of this work may thus have medical significance.

Keywords: health sciences,natural sciences,grainyhead-like,transcription factor,genetic regulation,tumor,skin cancer,squamous cell carcinoma,signaling,signal transduction,apoptosis,proliferation
Single-molecule studies of protein-protein and protein-DNA interactions, enabled by DNA origami. (DNA ORIGAMI DEVICES)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: Germany
Call:  (ERC-2010-StG_20091118, 2010)
Start date: 2010-11-01
End date: 2015-10-31
Duration (months): 60.0
Total project cost (EUR): 1494216.0
EU funding (EUR): 1494216.0
Participants: 1
Project status: CLOSED

Adhesive interactions between macromolecules are ubiquitously found in biology. Regulatory processes in biology depend on temporary physical inter-biomolecular interactions whose strengths are regulated by the internal state of the cell. Obtaining quantitative insight the dynamic strength of interactions between biomolecules has remained a difficult task. Single-molecule approaches can provide detailed insight into intra-molecular interactions in biomolecules. Yet, protein-protein and protein-DNA interactions have remained largely inaccessible. We propose to enable the single-molecule study of protein and protein-DNA interactions by taking advantage of the fine positional control afforded by DNA origami to overcome critical experimental challenges. As a first case study we plan to employ the DNA origami devices to study the single-molecule mechanics protein-protein and protein-DNA interactions that are relevant in the regulation of the galactose metabolism in yeast. We also seek to take steps towards a high-throughput single-molecule protein-DNA and protein-protein interaction assay to open access to a quantitative and combinatorial study of many different inter-macromolecular interactions, as well as to study the effects exerted by additional inhibiting or activating ligands. The proposed project will open up novel opportunities for a systematic study of macromolecular interactions in biology and is likely to deepen our understanding of regulatory processes in biology. Lessons that will be learned may suggest new ways to the rational design or identification of compounds that can prevent disease-causing interactions.

Keywords: single-molecule biophysics. protein-protein interactions. protein-dna interactions. molecular self-assembly. dna origami. dna nanotechnology
Direct observation of ligand binding and channel gating on individual ligand-gated ion channels (FLUOROPATCH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-04-01
End date: 2013-06-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Understanding the dynamics of ligand-gated ion channels is essential for understanding synaptic processes and neuronal signal integration (neurotransmitter gated channels) and intracellular signalling (cyclic nucleotide gated channels). Here we will combine single molecule fluorescence detection, with single channel electrophysiology, to detect ligand-binding and follow subsequent channel gating simultaneously. Single-channel patch-clamp alone can only measure two experimental states and their development in time: open and closed. Still, given some assumption, such data permitted construction of detailed kinetic models. Fluorescence detection can determines whether ligands are present or not, and the kinetics of the binding process. However, the nature of the ligand (agonist or antagonist) is not directly accessible. It was suggested more than 10 years [Edelstein 1997], that combining the two approaches on the single-molecule level will gain insights into the receptor mechanism. We will combine the two approaches to directly link the two molecular functional determining events (ligand binding and channel gating) within one experiment. Recently we implemented a combination of confocal single molecule fluorescence detection with single channel patch clamp, and showed (on the example of nAChR and fluorescent epibatidine) that such experiments are technically possible and feasible [manuscript in preparation]. We identified two parameters as limiting for the achievable time resolutions: counting noise and ligand diffusion into the confocal volume. Scope of this project includes: (1) identifying and analyzing biological systems with kinetics accessible to this approach, (2) developing techniques to reduce the time limitation, in particular the use of FRET to avoid the diffusion delay and (3) propose a model to describe the intra-molecular single transduction, and discuss it in comparison to models derived from single channel patch clamp alone.

Keywords: single-molecule,fluorescence,electrophysiology,patch clamp,ligand-gated ion channel
Expression and function or Resistin-like molecule alpha in asthma pathogenesis and fibrosis. (RELM-A IN THE LUNG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-07-01
End date: 2014-06-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Currently there is an epidemic of asthma in the western world and the incidence is rising in alarming rates. Experimentation in the asthma field has identified involvement of Th2 cytokines (e.g IL-4 and IL-13), chemokines, mucus hypersecretion, airway obstruction, eosinophilia, enhanced airway hyperreactivity to spasmogens in the asthmatic response and the presence of fibrosis. IL-4 and IL-13, “hallmark” Th2 associated cytokines are markedly elevated in the asthmatic lung and are central regulators of many of the hallmark features of disease and is now viewed as a critical cytokine in disease pathogenesis. Resistin is a hormone that was originally identified in adipose tissue and shown to promote insulin resistance and possibly obesity. However, it is now appreciated that resistin belongs to a newly defined family of resistin-like molecules (Relm) including Relm-alpha, Relm-beta and Relm-gamma that are potent innate immune regulators, and are implicated in Th2-associated immune responses. Indeed, Relm-alpha was originally identified in inflammatory zones associated with an experimental allergic airway disease model and has been called Found in Inflammatory Zones (FIZZ) 1. Recently, I have characterized a pro-inflammatory, regulatory role for Relm-alpha in experimental colitis. Furthermore, I have identified Relm-alpha as one of the highest upregulated IL-13 induced genes in the murine asthmatic lung. Collectively, implicating an important role for Relm-alpha in lung allergic inflammatory responses. The central hypothesis of this grant application is that allergen-induced lung inflammation and fibrosis are regulated by Relm-alpha. To define the role of Relm-alpha in such settings I aim to define the expression pattern, molecular regulation and cellular source for Relm-alpha expression following experimental-asthma and -fibrosis induction. Furthermore, I aim to define the function of Relm-alpha in experimental-asthma and -fibrosis. Finally, I will define the effects o

Keywords: asthma,fibrosis,eosinophils,il-13,resistin-like molecule
Integrated European Disaster Community Resilience (ICRED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-07-01
End date: 2014-06-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Recent events have shown how systems (regions, communities, structures etc.) are vulnerable to natural disasters of every type like human errors, systems failures, pandemic diseases and malevolent acts, including those involving cyber systems and weapon of mass destruction (chemical, biological, radiological ). In order to reduce the losses in these systems the emphasis has shifted to mitigations and preventive actions to be taken before the extreme event happens. Mitigation actions can reduce the vulnerability of a system; however, also if there is insufficient mitigation, or the event exceeds expectations, recovery is necessary to have a resilient function to the community. The objective of this proposal is to establish a framework for defining and measuring disaster resilience at the community scale. The framework will build on and expand previous research at MCEER linking the four resilience properties (robustness, redundancy, resourcefulness, and rapidity) and resilience dimensions (technical, organizational, societal, and economic) so as to measure the disaster resilience of capital assets (e.g., hospitals) and asset classes (e.g., health care facilities). Once developed, the framework will provide the basis for development of quantitative and qualitative models that measure the disaster resilience of communities. Over the longer term, these models will enable the development of decision-support software tools that help planners and other key decision makers and stakeholders to enhance the disaster resilience of their communities.

Keywords: technological sciences,social sciences,natural sciences
Integration of living cells with organic transistors for the rapid detection of toxins and enteric pathogens (CELLTOX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-07-01
End date: 2014-06-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The epithelium plays a significant role in resistance to infection in mammals, and is made up of a single layer of elongated, column-shaped cells that line the stomach and colon. This single layer of epithelial cells restricts the entry of toxins and pathogens, while selectively absorbing nutrients that sustain the body. Pathogens have devised multiple mechanisms to destroy the integrity of the intestinal epithelial barrier, compromising the normal absorption of water in the intestine and thereby causing diarrheal disease. The World Health Organization estimates that in 2005 alone 1.8 million people died from diarrheal diseases. CELLTOX is a novel type of biosensor for the detection of enteric pathogens and toxins, based on the principle of using live epithelial cells grown on an organic electrochemical transistor (OECT), which provides a very sensitive and convenient means of measuring ionic transport. When the epithelial cells form a monolayer, the integrity of the cell monolayer prohibits ion transport keeping the transistor in the ON state. Assault of the cells by an enteric pathogen or toxin will lead to a disruption of the cell monolayer and enable ion migration into the polymer, switching the transistor OFF. This novel “canary in a coal mine” platform will constitute a broad first-line diagnostic for gastrointestinal disease, with applications for food and water safety. It will lead to sensors that are fast, portable, inexpensive and label-free. Future use of different cell lines (eg. bronchial, dermal, etc.) with this platform will lead to a host of sensors for applications in medical diagnostics, agriculture, and environmental protection. This multidisciplinary project encompasses the disciplines of organic electronics, cell biology and microbiology, and will contribute to the successful and lasting reintegration of the applicant back to Europe.

Keywords: diagnostics,biomedical engineering,medical electronics,cell biology,microbiology,physical sciences,materials engineering,nanodevices