Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of Chemical Looping Gasification of microalgae for the 3rd-Generation BioFuels production (CLG-G3BioF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-11-30
Duration (months): 26.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: SIGNED

Global warming is leading to serious climate consequences worrying the world. What’s worse, the global CO2 budget will be used up soon, likely before 2030. Therefore, actions for CO2 mitigation are urgently needed to meet the agreed climate targets. Negative Emissions Technologies (NETs) are possibly the only implementable option to tackle this problem in such short period. This project stands on a novel NETs technology called Chemical Looping Gasification (CLG) and aims at producing the 3rd-Generation BioFuels (G3BioF). CLG is an unmixed gasification using oxygen carrier to transfer oxygen for gasification, thus fuel and air never mix. In light of this unique feature, the gasification product is absent of N2 dilution (thus the CO2 capture is inherent), and in the ash-free air reactor heat-exchanger corrosion is less possible. Microalgae is biomass, a major source for G3BioF, but it has very high content of problematic ash impurities. However, CLG is hypothesized capable to handle this fuel, in addition to its negative CO2 emissions. This project will first select suitable oxygen carrier for microalgae-CLG, through intensive experiments in a batch fluidized-bed reactor and an 1.5 kW continuous pilot. The selected oxygen carrier will be used in a 50 kW dual fluidized-bed pilot for proof of concept and performance optimization. A process model with reaction kinetics details will be established and used to analyze the technology integration with downstream processes. Finally, Life Cycle Assessment (LCA) will be applied to the process chain to evaluate the environmental impacts. This is expected to identify the most promising integration having the best economic and lowest environmental impact. Through the project, the applicant will progress as a scientist and gain at least skills of LCA, complex pilot operation, tar analysis. This project is ambitious for a much greener production of biofuels and the results are important to power a sustainable future.

Keywords: chemical looping oxygen carriers redox reactions fluidized bed carbon capture nets beccs biofuels microalgae
Targeted Respiratory Drug Delivery by Tribo Charged Sprays (TriboCharge)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-01-01
End date: 2025-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The main purpose of this proposal is to develop a radically new technology for very precisely delivering medicine to the human body. Targeted deposition of drug formulations to the lungs exhibits great promise in several treatments, e.g. siRNA treatment against lung cancer or mRNA vaccination against COVID-19. This requires oral and nasal inhalation for which spray pumps and nebulizers are widely used to transform an aqueous formulation into a soft mist spray. However producing the necessary drop size is hampered by droplet coalescence, making drops too large and polydisperse; because of this, they deposit in the wrong places. Large droplets between 10 and 50 micrometers deposit mostly in the upper respiratory tract (mouth, throat or nasal cavity) through ballistic impact on the mucosal tissue, whereas small droplets between 5 and 10 micrometers can be lifted by the airstreams and deposit mostly in the lower respiratory tract (bronchi and lungs). Our innovation relies on the charging of drops through the friction with the nozzle material. The charged drops repel and do not coalesce, allowing precise control of their size to target e.g. the lungs. This allows to achieve safe and effective targeted deposition of drugs and /or vaccines with hitherto unequaled precision.
Listening to change: acoustic monitoring of multi-trophic community dynamics in the face of increasingly variable and extreme environmental conditions (SOUNDCHANGE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 152623.68
EU funding (EUR): 152623.68
Participants: 3
Project status: SIGNED

Species are often predicted to lag behind the unprecedented pace of ecological changes imposed by current human activities. Such changes result not only in modification of the mean environmental values in an ecosystem but also in increasingly extreme and variable environmental conditions. These extreme and variable conditions operate at fine spatio-temporal scales. A mechanistic understanding of these dynamics in response to new environmental conditions thus requires monitoring, analysing and modelling at such fine spatio-temporal resolution. Passive acoustic monitoring (PAM) is a rapidly growing field of research that allows for an unparalleled temporal resolution and a wide taxonomic diversity of sound producing species in terrestrial and aquatic environments. In this context, I will use PAM to understand fine scale spatio-temporal community dynamics in response to increasingly extreme and variable environmental conditions. For that I plan to develop a methodological and conceptual framework to understand community dynamics at unprecedented spatio-temporal resolution. First, I will use unsupervised learning to characterise acoustic community composition, creating acoustic groups that I will ecologically identify. I will then use these groups to assess spatio-temporal variation of community composition in these environments and their associations using network models. Finally, I will use different change scenarios to investigate the potential impact of these changes on community dynamics. This research will increase our understanding of the importance of extreme and variable environmental conditions in driving community dynamics.

Keywords: ecoacoustics,community ecology,global change
Intelligent Framework for Inclusive and Seamless Transport Infrastructure and Mobility Services (MOVEO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Innovation actions
Countries involved: Spain,Greece,Italy,Lithuania,France,Switzerland,Poland,Germany,Denmark
Call: Improved transport infrastructure performance – Innovative digital tools and solutions to monitor and improve the management and operation of transport infrastructure (HORIZON-CL5-2024-D6-01, 2024)
Start date: 2025-05-01
End date: 2028-10-31
Duration (months): 42.0
Total project cost (EUR): 5735250.0
EU funding (EUR): 4998495.0
Participants: 17
Project status: SIGNED

In today’s rapidly evolving transport landscape, the need for more efficient, safer, and environmentally sustainable transport infrastructures and mobility services has never been greater. MOVEO proposes a scalable Intelligent Framework designed to overcome these challenges by fostering the integration of transport infrastructure and means through the use of cutting-edge digital technologies. This framework aims to optimize asset management, enhance multimodal capacity, and reduce emissions, all while prioritizing safety, accessibility, and inclusiveness. MOVEO's innovative approach is anchored in five key pillars: (1) Infrastructure assessment and redesign, (2) Inspection and monitoring, (3) Digitalized mobility, (4) Smart logistics, and (5) Inclusiveness and accessibility. These pillars are supported by Technology Innovation (TI) areas that collectively improve both transport infrastructures and modes. MOVEO will be validated through 5 demonstrators across various EU regions, encompassing different infrastructure types, climate conditions, and life cycle stages. The project's methodology is grounded in a co-creation approach, actively involving stakeholders throughout the project via an External Advisory Board (EAB). This approach fosters innovation by integrating diverse perspectives within the quintuple helix framework (academia, industry, government, civil society, and environment). Such collaboration ensures that MOVEO develops sustainable and competitive transport solutions that address the complex challenges of modern mobility. Bringing together expertise from 9 European countries, MOVEO unites the entire value chain in transport and digitalization, including specialists in inspection, monitoring, logistics, mobility, and inclusiveness, as well as end-users and transport infrastructure managers. MOVEO not only addresses today's pressing transport challenges but also lays the foundation for a more connected, sustainable, and safer transport future.

Keywords: multimodal transport,digital infrastructure,smart mobility,ghg reduction
Platform Optimisation To Enable NanomaTerIAL safety assessment for rapid commercialisation (POTENTIAL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Italy,Ireland,Luxembourg,Spain,Bulgaria,Germany,China,France
Call: Advanced characterisation methodologies to assess and predict the health and environmental risks of nanomaterials (RIA) (HORIZON-CL4-2022-DIGITAL-EMERGING-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2999787.5
EU funding (EUR): 2999787.5
Participants: 12
Project status: SIGNED

Advanced Nanomaterials (Ad-NMs) will lead a new industrial revolution and accelerate the transition to greener technologies and better health care. However, lack of practical and reliable protocols to evaluate Ad-NMs' potential hazards and risks has hindered innovation so far. POTENTIAL will generate a methodological framework comprising a set of harmonised protocols for characterisation, testing, grouping and read-across of Ad-NMs, that meet regulatory requirements for risk assessment, by improving: a) Advanced imaging protocols to quantify and characterize the intrinsic and extrinsic properties of Ad-NMs in complex matrices, using conventional analytical methods. b) Protocols to trace the evolution of Ad-NMs properties throughout their lifecycle, and methodologies for accelerated testing. c) in vitro multi-cellular models, in vivo (invertebrate) models, and ecotoxicological models for assessing the environmental and health hazard of Ad-NMs. Grouping and read-across approaches will build up on results from existing Horizon initiatives (GRACIOUS, SUNSHINE and HARMLESS), and will generate novel algorithms for similarity assessment, grouping hypotheses and Integrated Approaches to Testing and Assessments (IATAs). The protocols generated in the project will be validated through peer-reviewed publications and disseminated in Open Access. Furthermore, we will engage with the relevant standardisation bodies and organisations (OECD, ISO, CEN) to ensure that our approach can be translated into industry standards. The consortium comprises 11 European partners and 1 international partner (China), among which 4 high-tech SMEs specialised in Ad-NMs, and a high-tech incubator / accelerator. POTENTIAL contributes to the Horizon Europe workprogram by helping establish appropriate methods for cost-efficient assessment and prediction of the health and environmental effects of Ad-NMs, as well as supporting the inclusion of new methods to support safe-and-sustainable-by-design.

Keywords: advanced nanomaterials nanoplastic microplastic grouping read across safe and sustainable by design method protocol biodegradation bioactivity in vivo in vitro modelling
MONitoring and Assessing prevention and restoration soLutIons to combat deSertificAtion (MONALISA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Innovation actions
Countries involved: Italy,France,Spain,Denmark,Serbia,Switzerland,Greece,Tunisia,Romania
Call: Innovations to prevent and combat desertification (HORIZON-MISS-2023-SOIL-01, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 7325993.75
EU funding (EUR): 6991831.25
Participants: 23
Project status: SIGNED

The main goal of MONALISA is to identify and promote the expansion of innovative and tailored solutions to prevent and reverse land degradation and desertification (LDD) while showcasing their socio-economic and environmental effectiveness. MONALISA will put in place a transdisciplinary approach to integrate scientific and local knowledge, emerging from newly and established social learning spaces with multi-sector stakeholders and multi-disciplinary and interdisciplinary researchers. Work will be carried out in six Mediterranean case studies (CS), encompassing different levels of aridity across five countries (European: Italy, Spain and Greece; and non-European: Tunisia and Palestine). In the CS, the following solutions to prevent and restore LDD will be assessed and scaled-out: (i) innovative grazing systems (e.g., adaptive multi-paddock grazing systems); (ii) microbial-based solutions (e.g., biofertilizers and symbiotic N-fixing rhizobia); (iii) conservation agriculture practices (e.g., cover crops and reduced tillage); (iv) ecological restoration practices (e.g., harvesting and seeding of residual plant materials in protected grasslands, green infrastructures); (v) water harvesting techniques; (vi) treated wastewater reuse in agriculture. One of the main outputs of MONALISA will be a multi-modular practice-oriented Decision Support System, composed of several web-based applications, that will leverage innovative data and technologies, including from remote sensing and Artificial Intelligence. MONALISA will focus on new business opportunities with (and not only for) stakeholders, taking into account cost-benefit and market analysis and the promotion of public and private investments. The main goal will be the promotion and adoption of sustainable and environmentally-friendly solutions for LDD while contributing to support the economic growth of European and Mediterranean drylands.

Keywords: ldd risk methodological framework,med drylands,tailored and multi modular decision support system,microbial based solutions,organic fertilization,innovative grazing systems,treated wastewater
Dual Stimuli-Responsive Nanoparticles to Achieve Brain Multi-drugs Delivery Improving the Treatment of Neurodegenerative Disorders (BRAVERY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 2
Project status: SIGNED

Leading to disability and morbidity, neurodegenerative disorders (NDs) have a profound socio-economic impact. Given the aging of the population, they are raising remarkable concerns. Several active compounds for NDs treatment showed promising results in-vitro but failed in-vivo due to unfavorable biodistribution and limited biocompatibility. The nanocarriers (NC) proposed in the last decade have certainly improved brain delivery of active compounds, however, the limited bioavailability of the drug and biocompatibility issues make NDs treatment still a hot topic in neuroscience. With BRAVERY, I aim to achieve the spatiotemporal controlled drug release improving the bioavailability of neuroactive compounds in the brain without causing neurotoxicity. To do so, I propose to develop a novel biocompatible multi-drug NC capable of efficiently targeting the brain and releasing the loaded drugs in a controlled manner in response to specific stimuli, after intranasal administration. The proposed NC has three fundamental features: 1) It is mucoadhesive; 2) It degrades in response to two specific stimuli that allow achieving a spatiotemporally controlled release of the carried drugs in the brain; 3) Both NC and products of its degradation are biocompatible, thus limiting neurotoxicity. The biocompatibility and biodistribution of the NC will be evaluated by in-vitro, in-vivo, and ex-vivo analysis. As a proof of concept, the carrier will be loaded with active compounds and the biological effect observed will be compared with the one achieved by the free drugs. The project could have an immediate impact on NDs treatment improving the biological efficacy of the anti-prion protein drug used in this project as model drug. Such a versatile biocompatible multi-drug NC will pave the way toward a new era of NDs treatments, with a remarkable impact on society and health care systems worldwide.

Keywords: nanomedicine,controlled release,biocompatibility,biodistribution,brain delivery,cytotoxicity,in vitro studies,in vivo studies,neurodegenerative disease
JUSTice for Communities Adaptation and REsilience (JUST4CARE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: Spain,Belgium,United Kingdom,Türkiye,Hungary,Croatia,Norway
Call: Demonstration of approaches by regions and local authorities focused on increasing climate resilience of the most vulnerable social groups (just climate resilience) (HORIZON-MISS-2024-CLIMA-01, 2024)
Start date: 2025-11-01
End date: 2028-10-31
Duration (months): 36.0
Total project cost (EUR): 6881623.88
EU funding (EUR): 6551423.63
Participants: 16
Project status: SIGNED

The JUST4CARE project aims to transform climate adaptation practices by integrating principles of justice, equity, and resilience into urban and regional planning. Through inclusive and innovative approaches, the project addresses the specific needs of vulnerable and marginalized groups, who are disproportionately affected by climate change in European cities. The project will be implemented in pilot cities such as Madrid, Ankara, Budapest, and Zagreb, where equitable, data-driven solutions will be developed and tested. These solutions will be co-created with local communities and stakeholders, ensuring active participation and the implementation of equity-oriented policies. Additionally, AI-driven models will be used to integrate climate justice principles into risk assessments. The project will foster collaboration between cities and regions, allowing for the replication of effective solutions. JUST4CARE aligns with the work programme objectives by identifying, developing, and demonstrating equitable adaptation actions that enhance adaptive capacity and reduce vulnerability. It focuses on ensuring that the most vulnerable groups are meaningfully involved in the solution development process and directly benefit from them, promoting equity and climate resilience.

Keywords: climate justice,urban resilience,vulnerable communities,strategies against gentrification,ai driven solutions,socio economic equity,scalable innovation,transformative models,equitable access
Non-Animal Platform for Nanoparticle-Based Delivery across the blood-brain barrier Interface with Vehicle Evolution (NAP4DIVE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Finland,Sweden,Netherlands,Estonia,Czechia,France
Call: Innovative non-animal human-based tools and strategies for biomedical research (HORIZON-HLTH-2024-TOOL-05-two-stage, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 9130567.47
EU funding (EUR): 7767276.26
Participants: 11
Project status: SIGNED

The blood-brain barrier (BBB) is a major obstacle in treating diseases of the central nervous system (CNS) such as Parkinson's, Alzheimer's, Schizophrenia and brain cancer, affecting 180 million Europeans with less than 5% of current candidate drugs effectively reaching the brain. NAP4DIVE strives to revolutionize the traditionally expensive and inefficient drug development for these diseases by establishing advanced non-animal alternatives for testing and predicting nanoparticle (NP)-based drug delivery across the human BBB. This approach aligns with EU and global initiatives to reduce animal testing and advance human-based biomedical research models. The project will develop two complementary non-animal tools: a high-throughput BBB-on-Chip and an in silico model based on machine-learning (“NP Design Simulator”). A digital repository of optimized nanoparticle designs “NP Design Library” will be created to gather publicly available and newly obtained NP characterisation data, specialised for BBB delivery. The Design simulator screens thousands of NP designs to recommend the most promising ones, which will be tested in vitro on the microfluidic BBB-on-Chip with real-time measurement of barrier integrity. The accuracy and physiological relevance of both tools will be validated by the pharmaceutical partner through comparison with clinical and pre-clinical data. NAP4DIVE tools will reduce animal use in CNS drug development by up to 95% while saving 30 % of costs. By identifying nanoparticles for cross-BBB drug delivery and offering avenues for new effective treatment options, NAP4DIVE addresses one of the most pressing healthcare challenges of the century. A comprehensive HTA will demonstrate market readiness and cost-effectiveness of the tools, an ethical assessment will analyse harm reduction and engagement with regulators and policy makers will promote non-animal alternatives in preclinical testing on a larger scale.

Keywords: blood brain barrier,cns diseases,organ on chip,np design simulator,non animal models,sustainability,ethics,drug development,alzheimer s,parkinson s