Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
the Study of Orthographic Learning (SOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2024-10-14
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

Literacy acquisition can become a developmental bottleneck for a significant percentage of otherwise-competent children, preventing them from adequate progress in education. One key concept which is both, crucial to attain literacy proficiency, yet a severely understudied topic, is Orthographic Learning (OL). OL refers to the transition that a written word makes from being initially unfamiliar to becoming familiar, so that the word can be spelled accurately and read automatically. However, there are reasons to believe that, contrary to current OL theory, the skill of learning how to spell a word (OL-Spelling) might not be related to the ability to automatise the reading of a word (OL-Reading). This would result in a drastic revision of literacy acquisition theory. Therefore, the main scientific aim of the Study of Orthographic Learning (SOL) is to clarify whether there is a single OL system or two independent OL systems. To meet this goal, SOL will carry out two studies. Study 1 (Cádiz and Gibraltar) will 1) assess to what extent does OL-Reading correlate with OL-Spelling, 2) examine whether the cognitive predictors of OL-Reading and OL-Spelling differ, and 3) explore how the interaction between orthographic depth (English vs. Spanish) and OL clarifies whether there is one or two OL systems. Profiting from cutting-edge neuroimaging technology, Study 2 (BCBL, San Sebastián) will assess if the neural correlates of OL vary depending on the type of OL being assessed. Moreover, one H2020 cross‐cutting priority and two Europe 2020 Flagship Initiatives are i) promoting fairness in education from an early age, ii) contributing to creating an excellent education system and iii) preventing school-failure by improving literacy early on. Adopting an interdisciplinary approach, SOL will address these societal aims by implementing a teacher-training course on how to identify and help children at risk of developing OL-deficits using a novel OL-prediction test battery.

Keywords: orthographic learning,bilingualism,lexical reading,literacy acquisition,spelling,phonemic,awareness,naming speed ran,cross linguistic study
Photonic Integrated Comb Source: An Economic Feasibility Study (PICOMB)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Ireland
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Optical telecommunication networks are being put under huge strain by the rise in mobile video, video-on-demand and other bandwidth intensive services. New disruptive innovations are needed to avoid the impending 'capacity crunch' that that has the potential to affect the growth of the Internet with knock-on adverse effects for the European and global economy and society. Optical Frequency Comb Sources represent one such disruptive innovation. Optical Frequency Combs allow new modulation techniques to be used that increase the data carrying capacity and spectral efficiency of these networks. The benefits of Optical Frequency Combs are well known, but to date no-one has figured out a cost-efficient means to employ them in network equipment. Pilot Photonics Ltd., an Irish SME has licensed a suite of intellectual property around Optical Frequency Combs that has the potential to disrupt the market and displace the single mode lasers that have been used in long haul optical transport equipment for two decades. The intellectual property offers two capabilities: The cost-effective generation of a suitable optical comb, and the cost-efficient demultiplexing of that optical comb for modulation. Both techniques are suitable for photonic integration and can be fabricated using foundry compatible processes, enhancing their viability greatly. The comb generation technique is currently being marketed in bench-top form factor, while integrated prototypes have been produced. The demultiplexing concept has been proven in both bench-top experiments and in photonic integrated circuits. The innovation is in their combination to create value beyond the sum of the parts. The PICOMB project will examine the economic feasibility of this disruptive innovation, through detailed interaction with potential customers and partners. The outputs will be a detailed market survey, desired customer specifications, and cost model which will be combined into a comprehensive business plan.

Keywords: photonics,optical,telecommunication,frequency comb
Materials synthesis in vivo – intracellular formation of nanostructured silica by microalgae (BioSilica)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Israel
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Organisms evolved the ability to form a magnificent array of functional materials, which surpass any man-made product. A prominent example is diatoms, marine microalgae that form an intricate cell-wall made of meso-porous silica. Diatom silica is a tough, hierarchically built, and biocompatible material that is environmentally friendly and cheap, making it an exciting target for nanotechnology. Nevertheless, the principles of this regulated formation mechanism remain elusive. A persistent obstacle for elucidating biomineralization processes is the inaccessibility of the cellular environment for structural and chemical investigations. Recently, far-reaching developments in electron microscopy have revolutionized our abilities to investigate chemical processes inside living organisms. It is now becoming feasible to image and analyze, with nanometer-scale resolution, an intracellular mineralization process. This proposal aims to elucidate the intracellular mechanism of silica formation by diatoms. We will study cells undergoing the silicification process in situ, using a suite of state-of-the-art electron and X-ray imaging and spectroscopy tools. The combination of structural and chemical data will enable us to elucidate: 1) The concentration and stabilization mechanism of transient Si phases in the cell. 2) The nanoscale environment in which silica condensation takes place. 3) Genetic and environmental strategies to engineer the silicification process for designed outcomes. Diatom silica is a promising material for applications such as photonics, pharmaceuticals, and catalysis, which require hierarchical, high-surface area, nano-materials. The achievements of this project will inspire synthetic methodologies to produce and design nano-patterned silica, and genetically-engineer the biological silicification process to produce custom-made materials.

Keywords: diatom,silica,cryoem,biomineralization,electron tomography,biosilicification,morphogenesis
At first INsight: how our memories shape empathy for others’ physical pain (MEMPATHY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-01
End date: 2019-03-14
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Empathy is a multifaceted concept. It mostly relies on the ability to mirror and to explicitly infer others’ inner states. The simulation-theory (ST) account of Theory of Mind (ToM) suggests that people build an accurate representation of others’ inner states by using one’s own mind as a model, i.e. internally simulating others’ mind; for Theory-Theory (TT) such a representation is formed on the basis of common knowledge. Accumulating evidence supported the idea that our memories interact with empathy in building a representation of others’ inner states. In a series of two experiments, the current proposal is aimed at determining how, if any, the recruitment of autobiographical memory occurs when we empathize with others’ emotional experience, such as physical pain. Connectivity analysis applied to oscillatory activity, such as pattern similarity analysis, revealed that neural patterns present during memory formation are reactivated during memory retrieval, thus being a powerful tool to monitor a memory trace. By further combining excellent temporal resolution of electrophysiological measures and the excellent spatial resolution of functional imaging data in a multimodal EEG-fMRI recording, MEMPATHY aimed at establishing whether our memories are reactivated when we empathize with others' pain even when reactivation of our memories is detrimental to build an accurate representation of others’ pain. Importantly, by means of multi-modal neuroimaging measures and connectivity analysis, the proposal will allow to individuate the pathway and the direction of the dynamic communication within the brain network underlying memory and empathic processes.

Keywords: empathy,long term memory,electroencephalography,fmri
High Performance and High Yield Heterogeneous III-V/Si Photonic Integrated Circuits using a Thin and Uniform Bonding Layer (PICTURE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Ireland,Belgium,France,France,Czechia,United Kingdom,United Kingdom
Call: Photonics KET 2017 (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2021-12-31
Duration (months): 48.0
Total project cost (EUR): 4050477.5
EU funding (EUR): 3924532.5
Participants: 9
Project status: SIGNED

The objective of PICTURE project is to develop a photonic integration technology by bonding multi-III-V-dies of different epitaxial stacks to SOI wafers with a thinner and uniform dielectric bonding layer. This heterogeneous integration platform will enable higher performance lasers and photo-detectors using the optimized III-V dies. In addition, the thinner bonding layer will lead to record performance MOSCAP III-V/Si modulators, and to a new generation of wavelength tunable distributed feedback lasers. Moreover the full process including SOI process, bonding, III-V and back-end process will be made on a 200mm R&D CMOS line, leading to higher yield, smaller footprint and lower cost PICs. Two types of PICs with a total capacity of 400Gb/s will be developed, packaged and validated in system configuration. In parallel, PICTURE project will develop direct growth of high performance quantum-dot lasers and selective area growth on bonded templates for high density future generation of PICs. The project is coordinated by III-V Lab, and includes University of Southampton, CEA, University College London, Imec, Tyndall, Argotech and Nokia Bell Labs. The consortium is highly complementary, covering all skills required to achieve the project objectives: growth of semiconductor materials, silicon process and III-V process, design and characterization of PICs, prototyping and assessment of PICs in high bit rate digital communication systems: Apart from the adequacy of the consortium to achieve collectively the project objectives, the consortium partners have the potential to set up a comprehensive supply chain for the future exploitation of the project results, either by exploiting the results “in house” or by setting up suitable partnerships.

Keywords: silicon photonics
Semantics for PerfoRmant and scalable INteroperability of multimodal Transport – SPRINT (SPRINT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Spain,Italy,Italy,Italy,Belgium,Czechia
Call: Semantic framework for multimodal transport services (H2020-S2RJU-OC-2018, 2018)
Start date: 2018-12-01
End date: 2021-02-28
Duration (months): 27.0
Total project cost (EUR): 1999500.0
EU funding (EUR): 1999500.0
Participants: 10
Project status: CLOSED

The concept of Interoperability Framework (IF) is at the core of the Shift2Rail Innovation Programme (IP) 4, and it is the key concept for facilitating a seamless travel experience for users across borders and modes. The IF enables the technical interoperability of heterogeneous, multimodal transport-related services by relieving applications from the task of locating, harmonizing and understanding multiple and independent data and event sources, services, etc. A series of past and ongoing projects related to Shift2Rail IP4 (IT2Rail, ST4RT, GOF4R, CONNECTIVE) have developed and are refining and extending a set of core concepts and technologies that are part of the IF. The Semantics for PerfoRmant and scalable INteroperability of multimodal Transport (SPRINT) project will improve key aspects of the Shift2Rail IF to bring the market uptake of the multimodal transport ecosystem envisioned by IP4 closer to reality. In particular, the project will address the following specific challenges posed by the objectives of TD4.1 objectives and explicitly addressed by the S2R-OC-IP4-01-2018 call: • Improve IF performance and scalability to sustain a large deployment. • Simplify/automate all the necessary steps needed to integrate new services and sub-systems in the IP4 ecosystem. To this end, the project will: • Define a reference architecture for the Shift2Rail IF, which will take into account recent advances in the design and development of distributed systems, and in particular of cloud-based ones. • Define techniques facilitating – in particular by increasing their level of automation –activities that are central to the concept of IF, such as the collaborative creation and management of ontologies and of semantic-based mappings between heterogeneous data representations. • Demonstrate the proposed improvements to the IF through a proof-of-concept implementation that will reach at least TRL 4.

Keywords: interoperability framework,performance,scalability,automation,architectural solutions,agile ontology engineering,best practices and recommendations,semantic technologies,multimodal transport
Deciphering collagen mineralization process by dynamic imaging in liquid (DYNAMIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

Bone is a complex nanocomposite with outstanding mechanical properties arising from the nanoscale interaction between its two main building blocks: type I collagen fibrils and hydroxyapatite crystals. Despite its clinical relevance, the mechanisms governing bone formation are still poorly understood, mainly due to the complexity of the processes. During bone formation and remodeling, non-collagenous proteins and proteoglycans act synergistically to regulate the mineral deposition process, participating in multiple signaling pathways involving regulatory molecules, osteoblasts and osteoclasts. Many of the studies performed until now relayed into simplified in vitro models that hardly represent this complexity. Furthermore, methods traditionally applied only provide snapshots of this process, unable to extract dynamic information. To really understand the mechanisms regulating bone mineralization, we need to simultaneously visualize its different components in its context, to be able to monitor their interactions. In this project, I propose to combining liquid-phase electron microscopy and immunolabelling, with which I aim to bring together dynamic imaging of a complex biochemical process and the identification of the biomacromolecules involved. By recreating the mineralization conditions inside the liquid cell, I aim to obtain real time data on nucleation sites, crystal growth and mineralization dynamics. The combination of dynamic imaging with immunogold will allow me to monitor the direct interaction of these regulatory molecules with the mineral particles at nanoscale resolution. By means of this new exciting approach I expect to provide unprecedented data on the processes of bone formation and take a step forward in the application of LPEM in biological materials.

Keywords: biomineralization,liquid phase electron microscopy,collagen mineralization,apatite,bone,in situ electron microscopy,proteoglycans
Genetically engineered human pluripotent stem cells, functionalized silk-fibroin platforms and bio-inks: a novel solution for large-scale ex-vivo platelet production, transfusion and drug research (SilkFUSION)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Sweden,France,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2017-11-01
End date: 2022-10-31
Duration (months): 60.0
Total project cost (EUR): 2998500.01
EU funding (EUR): 2998500.0
Participants: 6
Project status: CLOSED

The demand for human platelets (plts) for medical research and clinical applications is massive. The primary goal of SilkFUSION is to engineer groundbreaking 3D nanotechnologies for large-scale production of blood plts for human transfusion from human pluripotent stem cells (hPSCs). Our hypothesis is that plt production ex-vivo can be optimized by providing megakaryocytes (Mks) with the correct physical and biochemical environment. To prove this, we will develop a unique technological platform by engineering non-thrombogenic silk-fibroin biomaterial with proteins, that were proven to promote a 55-fold gain in plt production, to create a three-dimensional ex-vivo bone marrow model that will enhance plt release from Mks derived from hPSCs. Our platform will include (i) novel applications to study pathogenetic mechanisms in patients with inherited platelet production disorders using genetically modified hPSCs; (ii) screening technology for predicting therapeutic efficacy of drugs for thrombocytopenic patients. The development of this technology will exploit an extremely innovative approach using silk-fibroin as a bio-ink for 3D printing a "live chip" containing viable Mks for reproducible drug testing. Our long-term vision is to foster the production of plts in-vitro for clinical transfusions in humans at a scale and cost that will address current supply challenges regarding (i) immunologically matched products to alloimmunised patients; (ii) “supercharged” platelets with recombinant FVIIa generating plts specifically suited for patients with acute haemorrhage resulting from trauma, surgery and wounded in conflict zones. The successful development and distribution of the SilkFUSION platforms will also offer researchers and clinicians specialized precision instruments and bio-ink kits for determining the safety and efficacy of drugs, reducing costs of ineffective therapies while promoting affordable functional strategies for the development of novel molecules.

Keywords: bone marrow,platelet transfusion,platelet ex vivo generation,megakaryocytes,silk biomaterial,bioreactor,drug testing,3d printing
Force Servo (Force Servo)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Lithuania
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Servo drives are small devices that have an output shaft, which can be positioned to specific angular positions by sending the servo a coded signal. Development of autonomous vehicles, drones, advanced robotic manipulators, camera stabilizers and other innovations require servo drives that are able to react and imitate the force of a living being. Absence of such solution creates a market gap in these industries and stagnate revolution of autonomous devices. Currently, there are no commercially available servo drives on the market that can fulfil the performance requirements needed for development of new generation autonomous devices. Force Servo (TRL 7), developed and patented by My Research is a new type of servo drive with controllable action force. The value of force is proportionate to the control signal and does not depend on the position of the arm, while the force is controlled with a force sensor. Force Servo improves technical characteristics of many autonomous devices, by providing simplicity, accuracy, lightness, energy efficiency, and replicating the force of a living being. To demonstrate advantages of Force Servo, the company will first commercialize a video camera stabilizer integrated with Force Servo drives. Such stabilizer is smaller, lighter and better performing than any alternative on the market. In the future, My Research will standardize and commercialize Force Servo drives in all relevant market segments – video stabilization, robotics, bionics, remote controlled vehicles, interactive interface, etc. To ensure successful commercialization, in Phase 1 of SME Instrument, Nord Robos Holding intends to develop an elaborate feasibility study for My Research Force Servo drive commercialization that would include: identification and contacting target users, verification of technological and economic viability, redesign of the product, and a business plan with an extensive financial, pricing, and IPR strategy.

Keywords: force servo,robotics,stabalisers,cameras,movie studio