Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Individual Variations and Cultural Evolution: The pottery wheel-throwing skill as a case study (SKILL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Both genetic and cultural human traits evolve through the successive mechanisms of: production of variations, transmission of variations, and differential selection of variations. From a behavioral point of view, individuals learn cultural traits channeled by social models and they participate themselves to transmit these traits to their peers and to the younger generations. How much are the cultural traits influence by the individual’s own style and his social surrounding? How individual variations lead to cultural divergences? The SKILL project addresses these issues, focusing on individuals practicing the pottery wheel-throwing. I will analyse an existing experimental dataset (collected with expert potters in France, India, and Nepal) and I will set up a new field experiment in Laos with expert potters and their novices. I will analyse both the behavior (hand positions) and its material consequences (xy coordinates of the pots’ profiles) with methods (inspiring from the ethology and the biology) allowing precise identification of the individual variations. Because motor learning of cultural skills does not result from strictly reproducing a model but rather as a behavior elicited by the observation of a model, I assume that the apprentice adapts the motor skill shown by his tutor. The adaptation hypothesis claims that apprentice develops idiosyncratic motor skill leading to inter-individual variations of the traditional shapes. Some of these variations can be transmitted and different selective forces can operate on them causing the evolution of the traditional shapes. At the crossroad of archaeology, anthropology, movement sciences, and ethnology, the SKILL project addresses the questions of the transmission and the evolution of the human material (artifacts) and non-material (motor skills) culture. It will complement existing work on pottery which still lacks direct insight into the nature of the skilled work required to produce them.

Keywords: motor skill,cultural evolution,cultural transmission,individual variation,pottery wheel throwing,expertise,artifacts variability,comparative studies
High load gear and bearings materials (HILOGEAR)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Germany,Italy
Call: High load gear and bearings materials (H2020-CS2-CFP04-2016-02, 2016)
Start date: 2017-05-01
End date: 2022-11-30
Duration (months): 67.0
Total project cost (EUR): 683565.0
EU funding (EUR): 450000.0
Participants: 3
Project status: SIGNED

The Ultra High Bypass Ratio technology achieved with the geared turbofan concept, that decouples fan and turbine speeds by means of an Integral Drive System (IDS), is an innovative architecture that can enable significant reduction in fuel burn, noise and emissions. The HILOGEAR (High load gear and bearings materials) project supports the aims to mature differentiating technologies and processes that could be introduced in the innovatve drive system module for the UHPE (Ultra High Propulsion Efficiency Engine) demonstrator. Since classical aerospace materials, although performant, do not exhibit all the necessary technical characteristics to fulfil both bearing and gears strength needs for their application in the UHPE power gearbox, innovative materials and heat treatments have to be investigated. Therefore the main HILOGEAR project tasks and goals will be: • the selection, jointly with the TM, of promising materials and surface treatments suitable both for gears and bearings • testing activities on bearings also in contaminated conditions • testing activities on gears in high load and high temperature conditions similar to those of new engines. The activity will be managed with a Phase & Gate approach and will include detailed technical / program, documentation, including planning, drawings, design report, risk analysis, test plan and test requirements, test results and test analysis reports.

Keywords: gears,bearings,innovative materials and heat treatments,high load,high temperature,scuffing,pitting,bending
Herpesvirus Effectors of RNA synthesis, Processing, Export and Stability (HERPES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-05-01
End date: 2022-04-30
Duration (months): 60.0
Total project cost (EUR): 1994375.0
EU funding (EUR): 1994375.0
Participants: 1
Project status: CLOSED

Herpes simplex virus 1 (HSV-1) is an important human pathogen, which intensively interacts with the cellular transcriptional machinery at multiple levels during lytic infection. Employing next-generation sequencing to study RNA synthesis, processing and translation in short intervals throughout lytic HSV-1 infection, my laboratory made the surprising observation that HSV-1 triggers widespread disruption of transcription termination of cellular but not viral genes. Transcription commonly extends for tens-of-thousands of nucleotides beyond poly(A)-sites and into downstream genes. In contrast to textbook knowledge, HSV-1 infection does not inhibit splicing but induces a broad range of aberrant splicing events associated with disruption of transcription termination. Exploring these fascinating phenomena will provide fundamental insights into RNA biology of human cells. The proposed work combines both hypothesis-driven and innovative unbiased screening approaches. I will utilise cutting-edge methodology ranging from high-throughput studies to advanced single molecule imaging. Thereby, I will detail the molecular mechanisms responsible for disruption of transcription termination and aberrant splicing. I will identify novel cellular proteins governing transcription termination using a genome-wide Cas9-knockout screen. I will develop RNA aptamer technology to visualise and track single RNA molecules suffering from poly(A) read-through. I will elucidate why transcription termination of some cellular and all viral genes remains unaltered throughout infection. I hypothesize that the alterations in RNA processing are depicted by specific changes in RNA Polymerase II CTD phosphorylation and in the associated proteins. I will characterise these dynamic changes using mNET-seq and quantitative proteomics. Finally, data-driven quantitative bioinformatic modelling will detail how the coupling of RNA synthesis, processing, export, stability and translation is orchestrated by HSV-1.

Keywords: herpes simplex virus,systems biology
Implementing Fuel Cells and Hydrogen Technologies in Ports (H2Ports)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Italy,Italy,Spain,Spain,Spain,Italy,Spain,Italy,Netherlands,Denmark
Call: Developing Fuel Cell applications for port/harbour ecosystems (H2020-JTI-FCH-2018-1, 2018)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 4117197.5
EU funding (EUR): 3999947.5
Participants: 15
Project status: SIGNED

Hydrogen is an energy carrier with great potential for clean, efficient power in transport applications. Hydrogen can be obtained from different sources, which in combination with fuel cells it can improve energy efficiency especially when hydrogen is produced by renewable energy sources. The action proposed tries to introduce hydrogen as an alternative fuel in the port industry. The H2Ports project is an Action aligned with the needs and objectives of the European Commission and the port industry. The aim is to provide efficient solutions to facilitate a fast evolution from a fossil fuel based industry towards a low carbon and zero-emission sector. Hydrogen has been proved in other logistics and transportation sectors as a solution to power machinery and vehicles, therefore the action proposes different pilots to bridge the gap between prototypes and pre-commercial products: • The first prototype will comprise a reach stacker powered with hydrogen and tested under a real life trial, in a Port Container Terminal. • The second prototype will comprise a yard tractor equipped with a set of fuel cells. The design will enable the tractor to perform different operations like container horizontal transport or ro-ro loading/unloading operations. • The third prototype will comprise a mobile Hydrogen supply station, which will provide the needed fuel under the appropriate thermodynamic conditions for guaranteeing the continuous working cycles of the abovementioned equipment. The H2Ports project would also have a transversal objective that consists on developing a sustainable hydrogen supply chain at the port, coordinating all actors involved: customers, hydrogen producers, suppliers, etc. The expected results of the project are to test and validate hydrogen-powered solutions in the port-maritime industry, with the aim of having applicable and real solutions without affecting to port operations while producing zero local emissions.

Keywords: ports,fuel cells,hydrogen,energy efficiency,emissions,noises,port equipment
The first ultra-high sensitive breast imaging device based on non-ionizing safe microwave (MammoWave)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Italy
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2017-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Breast cancer is the most common cancer in females. Regular screening is of paramount important for early diagnosis to reduce the incidence and increase the outcome of a cure. Current techniques based on ionizing radiation cannot be used in many cases. MammoWave is a mammography device based on safe microwave that enable a fast and accurate breast imaging allowing for an early detection of breast cancer, based on simple technology and low cost. MammoWave can be used any time, at any age and in any condition (pregnancy, specific illness etc.) for all patients since it does not use ionizing radiation. Defer to traditional mammography only cases positive for a first screening MammoWave, limiting the use of harmful radiation. The breast scanner consist of a cup that hold the breast of the patient in a prone position and of two antennas, one to transmit the microwave signal and one to receive. The breast is exposed to completely safe wave field. Both antennas are configured to be moved around the azimuth, to capture reflected electromagnetic field in all directions and measured by the receiving antenna. MammoWave is based on an innovative image reconstruction algorithm that processes the microwave signals according to the Huygens' principle: the result is able to identify the presence of any suspected tumor in the breast tissue. MammoWave addresses the market of hospitals, clinics and private doctors replying to their need of enhancing the specificity of mammography screening in breast cancer detection to battle the increasing rate of false-positive and false-negative results, which implies additional cost for the healthcare system and unnecessary distress for women. The Phase 1 project will be focused on establishing a complete supply chain, a sound business model and commercialization strategy, a planning of all activities for performing the clinical trials in hospital departments, as well as the elaboration of an industrialization and marketing plan

Keywords: breast cancer,cancer detection,non ionizing radiation,breast imaging,microwave imaging
Nanoencapsulation for Energy Storage and Controlled Release (ENERCAPSULE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2022-02-28
Duration (months): 78.0
Total project cost (EUR): 2004500.0
EU funding (EUR): 2004500.0
Participants: 1
Project status: CLOSED

The main vision of the project ENERCAPSULE is the development of nanoencapsulation technologies based on switchable nanoscale barriers for novel generation of controlled energy storage and delivery systems. These systems will be based on the “smart” nanocontainers (size below 200 nm) loaded with the energy-enriched active components: materials for thermal energy (both latent and based on chemical reactions) storage and substances for bioenergy (ATP or its components) storage for synthetic biology platforms. First novelty of the proposed project is the protection of the nanoscaled energy-enriched materials against environment during storage and controlled release of the encapsulated energy on demand only using both inherent properties of nanocontainer shell or biomimetic nanovalves introduced as shell components. Another main objective of the project is to study the structure and surface-to-volume properties of the energy enriched materials dispersed and encapsulated on nanoscale. The questions of stability of energy nanomaterials, influence of the nanocontainer shell on their energy capacity, homogeneity and operation lifetime will be investigated. Polymer organic nanocapsules with hollow interior and mesoporous carbon nanoparticles are chosen in the project as main types of the nanocontainer scaffolds for energy-enriched materials due to their high loading capacity and potential to design their shells to attain them controlled permeability properties. At the end of the project, developed novel energy storage and delivery systems will be combined within one network having several mechanisms for release and uptake of energy, which can be activated depending on type and intensity of the external impact (demand). The potential applications of such multienergy storage systems will be tested by industrial companies supporting the project.

Keywords: nanoencapsulation,energy storage,controlled release,energy capsules,nanodispersed energy,nanomaterials
FEderated interoperable SmarT ICT services deVelopment And testing pLatforms (FESTIVAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Italy,France,France,France
Call: Experimentation and development on federated Japan - EU testbeds (H2020-EUJ-2014, 2014)
Start date: 2014-10-01
End date: 2017-09-30
Duration (months): 36.0
Total project cost (EUR): 1499801.25
EU funding (EUR): 1499801.0
Participants: 7
Project status: CLOSED

The development of the Internet of Things is set to have a strong impact on many aspects of society. Test-beds and experimental facilities, both of small scale and up to city scale, will be an essential enabler to facilitate the development of this vision. Facilitating the access to these test-beds to a large community of experimenters approach is a key asset to the development of a large and active community of application developers, necessary to address the many challenges faced by European and Japanese societies. FESTIVAL project’s vision is to provide IoT experimentation platforms providing interaction facility with physical environments and end-users, where experimenters can validate their Smart ICT service developments in various domains such as smart city, smart building, smart public services, smart shopping, participatory sensing, etc. FESTIVAL testbeds will connect cyber world to the physical world, from large scale deployments at a city scale, to small platforms in lab environments and dedicated physical spaces simulating real-life settings. Those platforms will be connected and federated via homogeneous access APIs with an “Experimentation as a Service” (EaaS) model for experimenters to test their added value services. There have been long years of research work in Europe and Japan on federation of testbeds and more recently on IoT testbeds. FESTIVAL will as much as possible make reuse of existing software and hardware available in Europe and in Japan for building such testbeds. Mutually applying European enablers for Japanese testbeds and vice versa in real-life trials that the project will organize, FESTIVAL will bring have a strong impact in bridging the gap among the aforementioned component technologies. FESTIVAL, as a common testbed infrastructure for efficient communication and collaboration among stakeholders, will push European and Japanese IoT testbeds and their practices one step beyond the current state of the art.

Keywords: iot testbeds,smart ict,user involvment,federation of europe japan testbeds
The disruptive personalized machine-based genetic counseling platform (Igentify)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The promise of personalized medicine will soon materialize. However, this revolution will require genetic counsellors as key professional to facilitate patients´ informed decision-making. However, there are just 7,000 worldwide, insufficient to fulfil the ever-growing demand for these services (>40 million people tested in 2018). Likewise, health care organizations cannot implement genetic counselling (GC) as a tool to help patients understand, adapt and adjust to the medical and psychological consequences of their genetic tests results. Innovative automated solutions are needed to fully exploit the benefits from the upcoming genomic revolution to overcome, not just the shortage but also expensive, time consuming and not scalable current GC approach. At Igentify Ltd, an Israeli startup home to 32 highly-skilled individuals, we have created the first clinically-approved Igentify: A 4 module-based machine learning digital platform automating all stages from the GC process, starting from enrolment of the patient into the system, until the delivery of customized machine generated GC. Igentify incorporates 2 features simplifying and making scalable GC: (1) A set of algorithms analysing all genetic-related parameters (e.g. ethnicity, carrier frequency, medical history, lifestyle, etc.) to profile the individual as low or high-risk. (2) A revolutionary audio-visual asset generation algorithm that autonomously creates dynamic audio-visual content customized for patients, explaining all information in an educational way. We have commercial agreements with early adopters, including Northwell Health, Gene by Gene, Kaplan Medical Center or Meudehet, confirming Igentify´s business opportunity. We expect to gain a 4% market share within the global genetic testing market (€16.7 billion valuation by 2024, CAGR of 12.2%, period 2018-2024). This will translate into a revenue of € 104.06 M in 2026 (ROI of 7.04), while creating 150 jobs.

Keywords: genetic counselors,informed making decisions,genome sequence
Sustainable Polyurethane Elastomers for Footwear based on CO2 with improved properties (PUFOOTCO2)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Most hiking boots or sport shoes include a polyurethane outsole (elastomer) due to its lightness and higher damping properties compared with rubber. However, a major problem is its poor resistance to hydrolysis, which implies a degradation of the material and the appearance of cracks, when stored for a long time under certain temperature/humidity conditions without being used, thus crumbling completely. Moreover, the current production of polyurethanes is entirely dependent on fossil fuels, implying a large environmental impact. In this sense, PUFOOTCO2 aims to develop polyurethane elastomers with improved properties (high hydrolysis resistance) in an environmentally sustainable way, not depending on petroleum, and starting from CO2 as a raw material, offering the following benefits: - Technical benefits: CO2-based polyurethanes with improved properties to produce PU elastomers for the footwear industry, which implies a product with a longer shelf life. - Environmental benefits: CO2 is free, abundant, and renewable and it can be used as a chemical building block for the production of polymers, thus reducing the dependence on fossil fuels for obtaining polyurethanes, reducing the carbon footprint and contributing in a sustainable way to the decrease in CO2 emissions into the atmosphere. - Economic benefits: CO2 is significantly cheaper than conventional petroleum-based raw materials, so CO2-based polyurethane manufacturing costs are more favourable compared to conventional polyurethanes. Our company, SYNTHELAST S.A., has tested these “green polyols” on a small scale. Through this project we wish to validate this new generation of sustainable polyurethanes on an industrial scale successfully, meeting the technical requirements for footwear applications, with a high hydrolysis resistance and taking advantage of this huge market opportunity.

Keywords: polyurethane elastomers footwear,resistance to hydrolysis,hiking boots polyurethane outsole degradation,co2 chemical feedstock,co2 based polyols,polyurethanes