Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Free-space optical transmission links with unprecedented receiver sensitivity (FREESPACE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Sweden
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-11-01
End date: 2020-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Free-space optical communication links provide higher capacity and smaller beam divergence than their radio-frequency counterpart, and are increasingly being used for relatively short links often established for temporary purposes (e.g. outdoor sporting and concert events). They are also explored for extremely long reaches (e.g. between satellites, to the moon and beyond). In both cases, the sensitivity is fundamentally limited by the effect of diffraction, which results in the divergence of a free-space beam as it travels from the transmitter to the receiver. As there are practical limits on the size of the aperture permitted at both the transmitter and receiver, the diffraction results in a signal loss that limits the capacity and reach of the link. Our approach, which is to implement a unique noiseless optical amplifier in the receiver, is expected to result in a 40% transmission reach extension, or for a given reach target, reduce the aperture size of the optics (significant cost reduction) and increase the capacity. Our technique will help enable the transition from radio-frequency links to lightwave based links as it add significant performance benefits to the latter approach. We wish to use our new knowledge and expertise from our recent ERC AdG project to demonstrate, verify, and explore the commercial prospects of FSO transmission using phase-sensitive amplifiers in the receiver to improve the sensitivity, thus maximizing the possible link power budget, beyond what is possible with today’s approaches. We will work on market evaluation, technology verification, and commercialization strategy with the support from the Chalmers innovation office on our campus which has expertize on commercialization in the early stage. A goal of this project is to reach an agreement with commercial and/or institutional entities to pursue a field test of the PSA-based FSO technology.

Keywords: optical communication,low noise optical amplifiers,free space transmission
Next Generation Flow Diverter for the Treatment of Intracranial Aneurysms Delivering Improved Patient Outcomes and Healthcare Cost Savings (OXIFLOW)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-06-01
End date: 2024-01-31
Duration (months): 56.0
Total project cost (EUR): 4232828.5
EU funding (EUR): 2962979.95
Participants: 1
Project status: SIGNED

Each year ~51,000 EU citizens suffer a subarachnoid haemorrhage (SAH) resulting from the rupture of an intracranial aneurysm (IA), of whom 40% will die and 40% will suffer severe disabilities. However, SAH’s are entirely avoidable through treatment of ‘at risk’ unruptured IAs. Existing treatment options include: surgical clipping, an invasive, risky and expensive procedure but delivering excellent long-term resolution; and endovascular coiling, a cheaper and lower risk minimally invasive procedure but delivering poorer long-term resolution. Flow diverters (FDs) are an emerging endovascular device that divert blood flow away from the aneurysm thereby enabling natural healing. Whilst offering the potential of excellent long-term resolution at low risk and cost, existing FDs have failed to live up to expectations, reporting performance inferior to coiling. Limitations of existing FD’s are inherent to their mesh design that causes weak and non-uniform radial forces resulting in poor vessel apposition, variable porosity and device coning. Existing delivery systems also restrict use due to extension of the central guidewire during delivery. OxiFlow is a unique FD design based on origami principles and made from a shape memory Nitinol material. The innovative design enables optimum and uniform radial forces thereby overcoming the limitations of existing FDs. Furthermore, OxiFlow utilises a novel delivery system enabling complete user control of the central guidewire extension and thus use in small and tortuous vessels. OXIFLOW will evaluate safety and performance of the OxiFlow device through a 10-patient First-in-Man (FIM) study. Project activities include: device design freeze, transfer to pilot scale manufacture, pre-clinical testing; regulatory and ethical approvals; and FIM study implementation. The addressable EU & US market for OxiFlow is estimated at €463M. OE target €40.02M business growth over a 5-year period generating €73.56M cumulative revenues.

Keywords: intracranial aneurysms subarachnoid haemorrage endovascular flow diversion first in man clinical studies pilot manufacture pre clinical verification and validation glp animal study
Adapting the feed, the animal and the feeding techniques to improve the efficiency and sustainability of monogastric livestock production systems (Feed-a-Gene)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Spain,Spain,Spain,Spain,Hungary,China,Switzerland,France,France,France,Netherlands,Netherlands,Denmark,United Kingdom,Denmark,United Kingdom
Call: Genetics and nutrition and alternative feed sources for terrestrial livestock production (H2020-SFS-2014-2, 2014)
Start date: 2015-03-01
End date: 2020-02-29
Duration (months): 60.0
Total project cost (EUR): 9615108.75
EU funding (EUR): 8999544.0
Participants: 26
Project status: CLOSED

Feed-a-Gene aims to better adapt different components of monogastric livestock production systems (i.e., pigs, poultry and rabbits) to improve the overall efficiency and to reduce the environmental impact. This involves the development of new and alternative feed resources and feed technologies, the identification and selection of robust animals that are better adapted to fluctuating conditions, and the development of feeding techniques that allow optimizing the potential of the feed and the animal. To reach this overall objective, the project will: - Develop new and alternative feeds and feed technologies to make better use of local feed resources, green biomass and by-products of the food and biofuel industry. - Develop methods for the real-time characterization of the nutritional value of feeds to better use and adapt diets to animal requirements. - Develop new traits of feed efficiency and robustness allowing identification of individual variability to select animals that are more adapted to changes in feed and environmental conditions. - Develop biological models of livestock functioning to better understand and predict nutrient and energy utilization of animals along their productive trajectory. - Develop new management systems for precision feeding and precision farming combining data and knowledge from the feed, the animal, and the environment using innovative monitoring systems, feeders, and decision support tools. - Evaluate the overall sustainability of new management systems developed by the project. - Demonstrate the innovative technologies developed by the project in collaboration with partners from the feed industry, breeding companies, equipment manufacturers, and farmers’ organisations to promote the practical implementation of project results. - Disseminate new technologies that will increase animal production efficiency, whilst maintaining product quality and animal welfare and enhance EU food security to relevant stakeholders.

Keywords: precision feeding,feed processing,local resources,by products,feed efficiency,livestock production systems,pigs,poultry,rabbits,genetics,modelling,consumer acceptance,sustainability
“Animal-Free Testing for Acute Toxicity” (AFTAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: United Kingdom
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-07-01
End date: 2016-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

XCellR8 Limited aims to offer the first completely animal-free test for human acute toxicity. The primary focus is cosmetic product safety but the test may also later be applied to other industry sectors including household products, agrochemicals, medical devices and pharmaceuticals. In this context, animal-free means in vitro human cell culture based methods that do not utilise any animal-derived components. There are currently no validated in vitro tests for acute toxicity. Previous attempts to develop such tests used mouse cells and animal-derived components in the culture system and therefore still ultimately required the sacrifice of animals – an approach that is not considered acceptable by ethical cosmetic companies or by the public. The technological feasibility of the project has already been established, through existing tests of XCellR8’s internally developed proprietary methods. This feasibility assessment project is primarily required to address other practical, commercial, regulatory and financial aspects. It will also expand existing market research to assess the appetite of a greater cross-section of industry for such tests. During the project XCellR8 will investigate the alternative routes for test development and adoption by industry as a non-regulatory test to support product development. The ultimate objective is the international validation of the test and regulatory acceptance via incorporation into OECD Guidelines. The proposed project constitutes scientific advancement, using a fully human based method to assess human safety, as well as providing ethical, financial and commercial advantages over the use of animal tests. This offers true SME business model innovation, with an SME creating a pioneering solution that could bring a fundamental change to the manner in which cosmetic companies (and their suppliers) validate the safety of the ingredients used in their products.

Keywords: predictive toxicology,animal free testing,animal free test,in vitro,cosmetic safety
Creative Agency and Religious Minorities: ‘hidden galleries’ in the secret police archives in 20th Century Central and Eastern Europe (Hidden Galleries)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Ireland
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2021-03-31
Duration (months): 55.0
Total project cost (EUR): 990087.0
EU funding (EUR): 990087.0
Participants: 1
Project status: CLOSED

This project concerns the creative agency of religious minorities in the transformation of Central and Eastern Europe societies in the 20th century. It constitutes the first comparative research on the secret police archives in the region from the perspective of the history and anthropology of religion and offers a radical perspectival shift on the value and uses of the secret police archives away from questions of justice and truth to questions of creative agency and cultural patrimony. Interdisciplinary in nature it combines archival, anthropological and cultural studies approaches to provide a re-examination and re-contextualization of the holdings of secret police archives in three states; Romania, Moldova and Hungary. The secret police archives, in addition to containing millions of files on individuals monitored by the state, also constitute a hidden repository of confiscated religious art and publications of religious minorities that were persecuted in the 20th century under fascism and communism. The investigation of these materials will be complemented by ethnographic research and the impact of the research will be extended through a public exhibition of previously hidden materials. The project has three principal stages: 1) copy/retrieve and catalogue examples of this creative material from the archives; 2) engage in ethnographic research with the communities that produced this material in order to explore the meaning and power of these artistic creations at the time of their production and in the context of post-socialism; 3) curate and stage a touring exhibition that re-presents the narratives and experiences of religious groups through their own artistic creations in order to conduct research in real time on questions of religious pluralism and intolerance in contemporary society. Through these three steps, this project will shed fresh light on the role that minority religious groups played in challenging the hegemonic order and in extending pluralism.
PLASTtics to be CLEANED by sorting and separation of plastics and subsequent recycling of polymers, bromine flame retardants and antimony trioxide (PLAST2bCLEANED)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Spain,Germany,Spain,Belgium,Netherlands,Netherlands,Netherlands
Call: Methods to remove hazardous substances and contaminants from secondary raw materials (H2020-SC5-2018-2, 2018)
Start date: 2019-06-01
End date: 2024-02-29
Duration (months): 57.0
Total project cost (EUR): 4500830.0
EU funding (EUR): 4500830.0
Participants: 11
Project status: SIGNED

1.2 Million tons of mixed plastics arise from Waste Electrical and Electronic Equipment (WEEE) treatment in Europe and this quantity is still growing. WEEE plastics often contain undesired additives that hamper recycling in Europe. 75% of WEEE is currently exported to Asia where it is recycled to secondary plastics containing undesired (hazardous) substances or ending up in landfill where leaching occurs. Hence for WEEE plastics a closed loop solution is needed. PLAST2bCLEANED’s aim is to develop a recycling process for WEEE plastics in a technically feasible, environmentally sound and economically viable manner. To fulfil this aim, PLAST2bCLEANED addresses the recycling of the most common WEEE plastics acrylonitrile butadiene styrene (ABS) and high impact polystyrene (HIPS) that contain up to 20wt% brominated flame retardants (BFR) and up to 5wt% of the synergist antimony trioxide (ATO). PLAST2bCLEANED will close three loops: (1) polymer, (2) bromine, and (3) ATO. Key technologies developed within the project are: (1) improved sorting of HIPS and ABS that contain BFR from other polystyrene and ABS fractions; (2) dissolution of WEEE plastics in superheated solvents; (3) separation of additives to concentrate BFR and ATO fractions for recycling; (4) energy efficient recovery of solvent and of polymer. The developed technology will be integrated in a pilot facility with capacity of 2 kg/hr (TRL 5/6) delivering polymer samples. The developed technology can be applied to similar waste streams from other sectors, e.g. automotive. The combination of improved sorting and use of superheated solvents offers an economic and environmental advantage. First calculations indicate a sound business case. The consortium is well equipped to develop this technology and consist of partners to cover the whole value chain.

Keywords: plastics,additives,superheated,bromium,recycling,weee
Ancient Adhesives - A window on prehistoric technological complexity (AncientAdhesives)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2025-01-31
Duration (months): 72.0
Total project cost (EUR): 1499926.0
EU funding (EUR): 1499926.0
Participants: 1
Project status: SIGNED

AncientAdhesives addresses the most crucial problem in Palaeolithic archaeology: How to reliably infer cognitively complex behaviour in the deep past. To study the evolution of Neandertal and modern human cognitive capacities, certain find categories are taken to reflect behavioural and thus cognitive complexitye.g. Among these are art objects, personal ornaments and complex technology. Of these technology is best-suited to trace changing behavioural complexity, because 1) it is the least vulnerable to differential preservation, and 2) technological behaviours are present throughout the history of our genus. Adhesives are the oldest examples of highly complex technology. They are also known earlier from Neandertal than from modern human contexts. Understanding their technological complexity is thus essential to resolve debates on differences in cognitive complexity of both species. However, currently, there is no agreed-upon method to measure technological complexity. The aim of AncientAdhesives is to create the first reliable method to compare the complexity of Neandertal and modern human technologies. This is achieved through three main objectives: 1. Collate the first comprehensive body of knowledge on adhesives, including ethnography, archaeology and (experimental) material properties (e.g. preservation, production). 2. Develop a new archaeological methodology by modifying industrial process modelling for archaeological applications. 3. Evaluate the development of adhesive technological complexity through time and across species using a range of explicit complexity measures. By analysing adhesives, it is possible to measure technological complexity, to identify idiosyncratic behaviours and to track adoption and loss of complex technological know-how. This represents a step-change in debates about the development of behavioural complexity and differences/similarities between Neanderthals and modern humans.

Keywords: behavioural complexity,technological complexity,process modelling
Global views of cell type specification and differentiation (CellularBiographies)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 2411440.0
EU funding (EUR): 2411440.0
Participants: 1
Project status: SIGNED

Each cell in our body has a specific biography that is defined by its pedigree relationship with other cells (lineage) and by its history of gene expression (trajectory). A fundamental question in cellular and developmental biology has been how the lineage and trajectory of a cell lead to its specification and differentiation. Remarkable progress in genome editing and single-cell sequencing has generated the opportunity to understand this process at global scales and single-cell resolution. We have recently developed methods to reconstruct the cellular ancestry and transcriptional trajectories of cells during embryogenesis. The resulting lineage and trajectory trees can be analyzed to gain comprehensive views of how cellular diversity arises and how differentiation leads to physiologically specialized cell types. To generate such global views of cellular development, we will: 1. Define the cellular diversity and gene expression trajectories during zebrafish embryogenesis and organogenesis. Trajectory trees will be generated from scRNA-seq data and analyzed to reconstruct the gene expression pathways underlying fate specification. 2. Reveal the relationships between lineage and transcriptional trajectories during fate specification. Lineage trees will be generated by marking cells via genome editing and combined with trajectory trees to reveal the cellular paths towards fate specification. 3. Discover the gene expression cascades that remodel cells into physiologically functional types. Cell biological modules will be identified by comparing gene enrichment in differentiation trajectories and reveal the specialized and shared mechanisms of differentiation. These studies will help provide the first comprehensive and global view of the trajectories and lineages underlying vertebrate development. Our focus is on the zebrafish model system, but the data and concepts developed in this project will be applicable to other developmental and cellular systems.

Keywords: lineage,developmental biology of the cell,zebrafish
Revolutionary AR eyes for industrial maintenance (GLARTEK)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Portugal
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

GLARTEK product: is tool for industry, to interact and communicate in a new way, combining the Internet of Things (IoT) technology with Augmented Reality (AR). GLARTEK addresses a business opportunity for a solution merging two, still very distant, worlds - monitoring systems and setup/maintenance teams. Customers: C-level and factory / maintenance directors and industrial software developers and consultants Users: maintenance operators will have, on the field, a device with technical documentation and real-time information. Our objective is to sell, directly and indirectly, to industrial manufacturing companies, where downtimes and inadequate setups have tremendous economic environmental and social impact. Strategy: we conducted trials in 2017 to validate technically the product in customer’s industrial premises, and to have success case with verified ROI. Today we have a prototype that can be presented and deployed rapidly in industrial environments. Since direct and indirect sales have low scalability we aim to grow with a SaaS model. Industrial trials: the product was validated with early adopter customers in food and beverage (F&B) JM, a retailer in Portugal, Poland and Colombia, energy utility EDP (operates in 14 countries e.g. USA, Spain and Brazil), biofuel producer PRIO, Portugal, plastic equipment manufacturer Zoppas in Italy and energy efficiency in CCB buildings. All have stated willingness to buy GLARTEK and funded its trials (78,7 K€ for 5 trials). Contacts and negotiations for new trials are ongoing with Waters of Portugal, Bayer Italy, aeronautic manufacturing Mechacrome France, UNILEVER Netherlands, and Deutsche Bank. The target market is global and high-value: world market for manufacturing was more than 3.4 Trillion €. Goals: we expect to achieve 42.5 M€ of sales - 654 SaaS customers and installations in 216 facilities (2022). The feasibility study goal is to prepare for scaling the business with SaaS – Software as a Service.

Keywords: manufacturing,industrial management,maintenance,production optimisation