Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Memory Engram Maintenance and Expression (MEME)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Ireland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2023-01-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The goal of this project is to understand how specific memory engrams are physically stored in the brain. Connectionist theories of memory storage have guided research into the neuroscience of memory for over a half century, but have received little direct proof due to experimental limitations. The major confound that has limited direct testing of such theories has been an inability to identify the cells and circuits that store specific memories. Memory engram technology, which allows the tagging and in vivo manipulation of specific engram cells, has recently allowed us to overcome this empirical limitation and has revolutionised the way memory can be studied in rodent models. Based on our research it is now known that sparse populations of hippocampal neurons that were active during a defined learning experience are both sufficient and necessary for retrieval of specific contextual memories. More recently we have established that hippocampal engram cells preferentially synapse directly onto postsynaptic engram cells. This “engram cell connectivity” could provide the neurobiological substrate for the storage of multimodal memories through a distributed engram circuit. However it is currently unknown whether engram cell connectivity itself is important for memory function. The proposed integrative neuroscience project will employ inter-disciplinary methods to directly probe the importance of engram cell connectivity for memory retrieval, storage, and encoding. The outcomes will directly inform a novel and comprehensive neurobiological model of memory engram storage.

Keywords: engram,memory,integrative,connectivity,optogenetics,learning,retrieval,recall,connection
IMMERSE. INTERACT. INVESTIGATE (INFINITY)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Spain,Italy,Germany,Spain,Switzerland,Belgium,Greece,Finland,Greece,France,France,France,France,United States,Netherlands,United Kingdom,United Kingdom,Portugal
Call: Technologies to enhance the fight against crime and terrorism (H2020-SU-SEC-2019, 2019)
Start date: 2020-06-01
End date: 2023-08-31
Duration (months): 39.0
Total project cost (EUR): 6866503.75
EU funding (EUR): 6866503.75
Participants: 23
Project status: SIGNED

Infinity’s ambition is to become a flagship project against society’s most pressing cybercriminal, terrorist and hybrid threats. Synthesising the latest innovations in virtual and augmented reality, artificial intelligence and machine learning with big data and visual analytics, Infinity will deliver an integrated solution that aims to revolutionise data-driven investigations. Bringing together a strong representation from national and supranational agencies with an end-user-driven design, it will directly address the core needs of contemporary law enforcement. Specifically, it will equip investigators and analysts with cutting-edge tools to acquire, process, visualise and act upon the enormous quantities of data they are faced with every day. Bolstered by cognitive research, automated systems and instinctive interfaces and controls, Infinity will be designed and developed to maximise the potential of individual investigators. On a collective level, the immersive collaborative environment offered by Infinity will enable co-located and remote LEA cooperation in ways that have not yet been realised. This end-to-end system for LEA operations will cover the full investigative cycle, including generating reports for decision-makers and admissible evidence to demonstrate to juries and judges. Ultimately, the solutions offered by Infinity will propel LEAs ahead of traditional and evolving complex, hybrid and transnational threats and protect the societies they serve.

Keywords: virtual reality,augmented reality,visualization,cognition,collaborative environment,intelligence analysis
Proving Operations of Drones with Initial UTM Management (PODIUM)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Belgium,Belgium,France,France,France,France,France,France,France,France,Netherlands,Denmark,Denmark
Call: Safe integration of drones (H2020-SESAR-2016-2, 2016)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 3199900.0
EU funding (EUR): 1395649.25
Participants: 31
Project status: CLOSED

The PODIUM project comprises four complementary, large scale demonstrations, taking place in Denmark, France and the Netherlands where more than 185 drone flights will be conducted. Its partners’ quick wins integrated UTM solution will be demonstrated in a broad range of realistic operational conditions of drone operations (VLOS and BVLOS) in VLL airspace (controlled & uncontrolled airspace; urban, rural and in the vicinity of airports) interacting with manned traffic. Each of its four sites has its own specificities (e.g. routine day to day operations, emphasis on UTM/ATM communication, normal/abnormal conditions). The demonstrations will notably enable its safe and secure use by various categories of users (e.g. authorities, drone operations, drone pilots) and for many types of drone operations (e.g. electricity line inspection, emergency services). Together the four sites demonstrations ensure a comprehensive and extensive demonstration of the full potential and technology readiness level of the PODIUM UTM functionalities (from Before-flight to Post-flight with a special focus on in-flight dynamic geo-fencing). PODIUM is a U-Space compliant demonstration. Under EUROCONTROL leadership, PODIUM consortium comprises 10 members,17 linked third parties and 4 sub-contractors, including many in-kind contributions. By bringing together drone actors (UTM provider, drone operators, drone trackers manufacturers), ATM actors (ANSPs, ATM system integrator & others) and infrastructure providers (drone demonstrations centers, telecommunication network) supported by their local authorities in its Advisory Board, PODIUM project will naturally improve the links between the drone and the ATM communities therefore contributing to a safer integration of drone operation in the European airspace and maximising the outreach of the project at regulatory and standardisation levels.

Keywords: utm u space drones very large scale demonstrations rpas
Allele-specific Deconvolution of Tumour DNA Methylation and Expression Data to Reveal Underlying Cell Populations (DECODE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-08-01
End date: 2018-07-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Owing to advances in sequencing technology, we are now beginning to understand the molecular mechanisms underlying cancer development and evolution. Tumours however are heterogeneous, often containing admixed normal cells and different (sub)clones, confounding interpretation of the massive amounts of data flowing from large initiatives such as the International Cancer Genome Consortium. To address this issue, I will develop methods that disentangle tumour bulk gene expression (RNA-Seq) and DNA methylation (Bisulphite-Seq) data to accurately reveal the states of the distinct underlying cell populations. The innovative algorithms will derive estimates of the allele-specific expression/methylation rates and tumour copy number profiles from the data and use them to separate the signal coming from the tumour from that of the normal cells. In a second step, the method leverages the wealth of available cancer ‘omics data using a recommender-system approach to complete the deconvolution. Careful validation will come from teasing apart computationally mixed pure samples as well as from ongoing and planned collaborative single-cell sequencing projects. A detailed analysis of tumour expression and DNA methylation heterogeneity on these single-cell datasets will guide further methodological advances. As an intrinsic part of the project, massive pan-cancer datasets will be deconvoluted. Drawing on the pure transcriptomes and epigenomes, I will construct a more comprehensive taxonomy of cancers, laying the basis for significant improvements in clinical prognostic prediction and personalised treatment. This project will shift the paradigm of genomic tumour heterogeneity to include the more actionable transcriptome and epigenome. In turn this will lead to a better understanding of how (epi)genomic alterations translate into the transcriptomic (and proteomic, interactomic, …) changes driving cancer evolution.

Keywords: tumour heterogeneity,molecular archaeology,pan cancer analysis,single cell sequencing
Research, Connections, Networks and Culture - Use of Projects, Games, Research And Digital in Education (Reconnect Upgrade 20)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Serbia,Serbia,Serbia
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-06-01
End date: 2021-02-28
Duration (months): 9.0
Total project cost (EUR): 81625.0
EU funding (EUR): 80000.0
Participants: 6
Project status: CLOSED

Knowing that the EU H2020 funds only the best research and innovation projects which generate knowledge for the benefit of society, the Reconnect Upgrade 20.20 project has the ultimate goal to identify, and enhance the public recognition of those remarkable researchers, who are charged with leading the societal progress towards Horizon Europe, and stimulate promotion of research careers among the young pupils and students who will take over in the coming EU framework programmes. Reconnect Upgrade 20.20 project reflects Europe in a changing world which is asked to generate science that is smart, transformational, anticipating, co-creational, and more responsive to stakeholders’ engagement. Researchers need to rise to the societal challenges framed in Sustainable Development Goals and referred to in Towards A Sustainable Europe By 2030, while the general public needs recognize their added value in translating the EU funding for science and education into sustainable solutions that impact the daily life. Since the new EU framework programme for research and innovation is just around the corner, Reconnect Upgrade 20.20 project focuses on this transitional phase and sheds a light on the triangle among the science, industry and citizens, which is well reflected in the EU RIS3 Smart Specialisation Strategies that should bring in a demand-driven dimension, foster innovation partnerships emphasizing greater co-ordination between different societal stakeholders, and align resources and strategies between private and public actors.

Keywords: digital,augmented reality,artificial intelligence,up to date,innovative,sustainable,engaging,entrepreneurial,ground breaking,excellent,collaborative
Towards prevention, early diagnosis, and noninvasive treatment of uterine leiomyomas through molecular classification (MYCLASS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Finland
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-06-01
End date: 2021-05-31
Duration (months): 60.0
Total project cost (EUR): 2499099.0
EU funding (EUR): 2499099.0
Participants: 1
Project status: CLOSED

Every fourth woman suffers from uterine leiomyomas (ULs) – benign tumors of the uterine smooth muscle wall - at some point in premenopausal life. ULs, also called myomas or fibroids, cause a substantial health burden through symptoms such as excessive uterine bleeding, abdominal pain and infertility. These tumors are the most common cause of hysterectomy. Considering the impact that ULs have to women’s health, they are severely understudied. Our breakthrough work has shed important new light on the biology and genesis of ULs. In this ERC proposal we hypothesize that ULs can emerge through several distinct mechanisms and anticipate that each mechanism contributes to somewhat different tumor biology, clinicopathological features, and response to treatment. Also, we hypothesize that predisposing genetic variants may confer susceptibility to a particular UL subclass. To test these hypotheses, we shall create multiple layers of high-throughput data on clinicopathologically characterized ULs, including copy number variation, whole genome sequence, gene expression, and methylome profiles. Integration of these data should establish the existence and key characteristics of the different UL subclasses. Finally, we shall examine the effect of currently used drugs as well as new lead compounds in response to treatment, stratified per UL subclass. These efforts will 1) provide biological insight into molecular mechanisms driving the UL genesis and lay the scientific basis of their molecular classification, 2) describe the key characteristics of each class, 3) provide key biomarkers and molecular tools for routine diagnosis of UL subclasses, as well as clues to their targeted treatment, and 4) produce tools for detection of hereditary predisposition to ULs. This ERC project will be an important step towards non-invasive management of ULs. Reaching this goal would benefit hundreds of millions of women.

Keywords: gynecology,cancer genomics,tumor predisposition,tumorigenesis,cancer,cancer genetics,medical genetics,molecular classification
General and Light Aviation Head-up Display (GALAHD)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain,Italy
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

A head-up display (HUD) is a semi-transparent screen placed above the cockpit in the direction of the forward view that displays the flight parameters derived from flight instruments on windshield, allowing pilots to keep their look on windshield without being forced to monitor cockpit’s instrumentation. This kind of display is widely used in commercial and military aircraft, since it plays a significant role in supporting pilots and reducing collision risk with terrain.However, HUD combines expensive and complex technologies, bringing to a high minimum selling price of roughly €40,000 for the more expensive sector of business aviation. This amount is not affordable for general aviation (GA) users, which represent the majority of world air traffic with 103,000 aircrafts based in Europe in 2014. Therefore, terrain collision accidents mainly take place in general aviation, representing 81% of cases and 17% of victims.In this context, GalaHD proposes a ground-breaking device, based on HUD technology, designed to reduce pilot workload and support the aircraft control with a clear and intuitive interface and, at the same time, reduced development costs. Known as GalaHD - General And Light Aviation Head-up Display -, our approach is to introduce a navigation device based on Head-Up Displays (HUD) technology in Light-sport Aviation (LSA) and later certify it for use on normal category planes (CS-23 - Utility, Aerobatic and Commuter Aeroplanes – EASA). The exploitation of GalaHD will lead to international growth of the consortium members. Furthermore, a widespread deployment of GalaHD will significantly reduce the number of accidents across general aviation throughout Europe.

Keywords: head up display,general aviation,aircraft,safety
Creating an evaluation and research strategy and an evidence base for eHealth systems to improve the quality of data collection and care in low and middle income settings (Global eHealth)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Healthcare in low and middle income countries (LMICs) is undergoing rapid change and addressing a widening range of diseases. The needs of the disadvantaged, underserved and remote communities are increasingly recognized, and there is an emphasis on disease surveillance, measuring and improving quality of care and reducing preventable adverse events. The timely and accurate collection, analysis and use of health information is essential for all these initiatives, and eHealth systems are increasingly seen as essential. The Fellow has led several multi-national eHealth projects in LMICs for over a decade including electronic medical record systems (EMRs). In 2004 he co-founded and co-leads the OpenMRS open source EMR system now deployed in more than 40 LMICs, and it’s initial roll out in Rwanda, now in over 300 clinics. He has led or co-led 18 innovative evaluation studies of eHealth and mHealth systems demonstrating impacts on clinical care processes and laboratory data access including the first randomized controlled trial of a lab information system in a LMIC to show clinical benefit. The objectives of this fellowship are to (1) evaluate with an RCT the clinical and health service impacts of an eHealth systems in an LMIC, and to evaluate system performance and costs. (2) improve the quality and use of clinical data from EMR systems for care and research in both the EU and in LMICs, focusing on heart disease and diabetes and (3) create a Global eHealth group at Leeds University to strengthen European and Global capacity in eHealth development, implementation and evaluation. The Fellowship builds on the innovative and internationally recognized work of the Fellow, in collaboration with Professor Jeremy Wyatt a world leading expert on eHealth evaluation at the University of Leeds, UK. It will provide a unique opportunity for the Fellow to re-integrate into Europe, make a major step forward in his skills and leadership in eHealth, and achieve a senior career position.

Keywords: global ehealth,evaluation,developing countries
Consolidating the capacities of EATRIS-ERIC for Personalised Medicine (EATRIS-Plus)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Ireland,Italy,Spain,Ireland,Italy,Belgium,Norway,Bulgaria,Finland,Finland,Croatia,Slovenia,Sweden,Latvia,France,Czechia,Czechia,Netherlands,Netherlands,Portugal,Luxembourg
Call: Individual support to ESFRI and other world-class research infrastructures (H2020-INFRADEV-2019-2, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 4999023.75
EU funding (EUR): 4999023.25
Participants: 27
Project status: SIGNED

In the first five years of operations, EATRIS has shown strong proof of concept of the value of the services portfolio, with users ranging from academia, SMEs, large pharma, to biotech and research funding organisations. The overarching aim of EATRIS-Plus is to support the long-term sustainability (LTS) of EATRIS by delivering innovative scientific tools to the research community, strengthening the infrastructure’s financial model and reinforcing EATRIS leadership in the European Research Area (ERA), particularly in the field of Personalised Medicine (PM) research and development. Specific objectives are: (i) To consolidate EATRIS capacities in the field of PM to better serve academia and industry and augment the number of EATRIS Innovation Hubs with large pharma; (ii) To further strengthen the LTS of EATRIS financial model; (iii) To drive patient empowerment through active involvement in the infrastructure’s operations; (iv) To expand strategic partnerships with Research Infrastructures and other relevant stakeholders. The proposal relies on a scientific and technological programme combined with capacity-building activities across 16 EU countries, with the support of two umbrella organisations representing patient organisations and SMEs. EATRIS-Plus will help pooling and exploiting the translational academic capacities of the infrastructure in omic technologies to enable researchers to better address the scientific and societal challenge of PM. Additionally, the coordination office and 13 existing national nodes of the infrastructure will participate in implementing joint outreach, training, industry engagement and international collaboration activities to further build national capacity, increase users’ trust and strengthen EATRIS and the ERA global scientific leadership.

Keywords: public private collaboration,personalised medicine,translational research,biomarker validation,omic technologies,data management,quality assessment,sustainability