Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Functions of Genomic Hypomethylation in Gametogenesis (hypomethGENOME)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499995.0
EU funding (EUR): 1499995.0
Participants: 1
Project status: SIGNED

Replication in S phase duplicates not only the genome but also the epigenome, to ensure cell identity is propagated and genome stability maintained in daughter cells. Epigenome propagation in development has been understudied due to lack of appropriate methods, even though replication is widely accepted to be a primary vehicle through which programmed epigenetic changes occur in vivo. In mammalian germline development, the epigenome is reprogrammed via impairment of the epigenome maintenance network. By dividing without maintaining core components of the epigenome, primordial germ cells harbor genomes devoid of the crucial repressive mark DNA methylation. Hypomethylation is destabilizing because it de-represses transposable elements. Despite this, oocytes arrest in a hypomethylated state, regaining methylation only in preparation for ovulation as part of puberty. In parallel, two-thirds of the oocyte pool dies around birth in mammals, and the features delineating oocytes that survive this process from those that die are unclear. I propose that hypomethylation is alternately selected for and against across gametogenesis. Specifically, that hypomethylation a positive feature in primordial germ cells but a deleterious feature in the female germline after sex specification. To test this, we will develop novel transgenic mouse models and technologies to study epigenome propagation in vivo, and utilize state-of-the-art sequencing, mass spectrometry, microscopy, and metabolic labelling approaches. By developing a method for tracking DNA molecules and their associated methyl marks across division in live animals and embryos, we will establish an unprecedented technology for understanding epigenome propagation in development. Cumulatively, this work will uncover the functions and consequences of global hypomethylation in the germline, and provide groundbreaking insights into the nature of mitotic and intergenerational epigenetic inheritance in vivo.

Keywords: epigenetic reprogramming,dna methylation,primordial germ cells,oocytes,chromatin,epigenome maintenance,gametogenesis,oocyte attrition,nucleoside mass spectrometry,lineage tracing,metabolic labelling,functional genomics,mouse
Green Investments, Household Finances, and Local Economic Dynamics (GREENVEST)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

GREENVEST fuses the power of satellite data and cutting-edge econometric analysis to study patterns emerging in two under-studied, inter-connected phenomena at the crossroads of finance, environmental science, and economics: (1) green investments and local economies and (2) the contribution of market dynamics on biodiversity loss and pollution. Drawing on research from environmental economics, climate science, finance, and business strategy, I will explore and reveal to what extent households' financial welfare is impacted by public and private investments in green projects and how the investments, performance, and environmental impact of local firms and banks are affected by government green initiatives such as the EU Green Deal and the US Inflation Reduction Act (IRA). GREENVEST’s new modeling approach will not only enable environmental economists to estimate the financial value of natural ecosystems, but highlight for the first time the financial value of nature conservation and the financial benefits of investments in nature-based solutions. With the world-renowned business school IESE as my host and channeling my project through its Institute of Sustainable Leadership, I will grow new skills in project management skills, R&I insight communication and satellite and biodiversity data analysis to become a leading voice in biodiversity and sustainable finance in both academia and as a European policy influencer about green investments in service to public, non-profit, and private institutions.

Keywords: nature conservation,sustainable finance,household finance,labor income,savings,credit markets,competition,eu green deal,pollution,nature loss,market concentration
MCAA new horizon: Enhancing the impact of MSCA Alumni on the European Research Landscape (MCAA-new-horizon)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: MSCA other
Action type: Coordination and support actions
Countries involved: Belgium
Call: Support to the Marie Curie Alumni Association (HORIZON-MSCA-2022-ALUMNI-IBA, 2022)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 2387500.0
EU funding (EUR): 2387500.0
Participants: 1
Project status: SIGNED

The MCAA-new-horizon project will provide support to the management of the Marie Curie Alumni Association (MCAA) as well as to the implementation of its core activities. The MCAA is an international non-profit organisation that brings together current and past Marie Skłodowska-Curie Actions (MSCA) fellows. Its main goal is to increase the impact of the MSCA, by promoting networking opportunities for the alumni, by supporting their career development, and by providing feedback to the European Commission (and other organisations) on the MSCA and other policies. The project activities will be organised in five core work packages: - Governance & Management. It includes activities aiming to ensure a proper management of the association (e.g. support to governing bodies, Working Groups and regional Chapters (WG&C), and the overall administration of the MCAA. - Alumni engagement, networking and services. It includes activities aiming to engage MSCA fellows in the MCAA and its initiatives (such as the annual conference and events organised by WG&C). It also aims to provide support for the career development of the MSCA alumni (via access to education and training opportunities, financial support for the participation in events and courses, promotion of networking opportunities, etc.) - Policy & Institutional relations. It mostly concerns the provision of feedback to the Commission on the MSCA and other policies (partly based on surveys to the MCAA members). It also includes all institutional relations with relevant scientific and non-scientific organisations that could represent a benefit for the MSCA alumni (e.g. through partnership agreement with institutions). - Communication & Outreach. It includes all activities aiming to disseminate the activities of the association, engage MSCA fellows, and promote the MSCA to different audiences worldwide. - IT infrastructure. It will mostly deal with the further development of the website as a digital ecosystem.

Keywords: excellence alumni career development researcher research innovation mcaa msca marie curie
SUstainable federatioN of Research Infrastructures for Scaling-up Experimentation in 6G (SUNRISE-6G)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Greece,Spain,Germany,France,Ireland,Finland,Belgium,Italy,Cyprus,Sweden,Portugal,Poland
Call: Complementary SNS experimental Pan-EU federated Infrastructure (HORIZON-JU-SNS-2023, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 13929059.25
EU funding (EUR): 13120676.76
Participants: 29
Project status: SIGNED

6G is expected to emerge as key enabler for the intelligent digital society of 2030 and beyond, providing superior performance via groundbreaking access technologies, such as joint communication and sensing, cell-free, Radio Intelligent Surfaces, and ubiquitous wireless intelligence . Most importantly, 6G is expected to trigger a total rethink of network architecture design, which builds on the key idea of new stakeholders entering into the value chain of future networks. The SUNRISE-6G approach is inspired by the “network of networks” concept of 6G Networks, aiming to integrate all private and public infrastructures under a massively scalable internet-like architecture. SUNRISE-6G similarly aspires to create a federation of 6G test infrastructures in a pan-european facility that will support converged Testing as a Service (TaaS) workflows and tools, a unified catalogue of 6G enablers publicly accessible by experimenters, and cross-domain vertical application onboarding. Experimentation and vertical application onboarding are offered via a Tenant Web Portal, that acts as a single-entry point to the facility, serving end users (e.g., experimenters) and tenants (e.g., vertical developers, infrastructure owners, 6G component manufactures). The project execution is based on 4 pillars, delivering: (a) the Implementation of new 6G enablers, complementary to existing ones being developed in SNS Phase 1 projects, (b) A truly scalable and 3GPP compliant Federation solution that provides access to heterogeneous resources and devices from all Europe, (c) A Federated AI plane aligned with AIaaS and MLOPS paradigms, which promotes a collaborative approach to AI research which benefits immensely from scaling-up datasets and models and (d) a commonly adopted Experimentation Plane, which offers common workflows to experimenters.

Keywords: experimentation platform,camara initiative,federation,aiaas,intent driven experimentation
Reducing Iron Oxides without Carbon by using Hydrogen-Plasma (ROC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2491836.0
EU funding (EUR): 2491836.0
Participants: 1
Project status: SIGNED

With 1.8 billion tons produced per year, steel is the dominant metallic material. It can be recycled by melting scrap, a resource satisfying at most 30% of the demand. Hence, fresh steel must be produced in huge amounts, from oxide minerals reduced by CO in blast furnaces, followed by partial removal of C by O2 in converters. These two processes create ~2.1 tons CO2 per ton of steel, qualifying steelmaking as the largest single greenhouse gas emitter on earth (~8% of all emissions). ROC tackles the fundamental science needed to drastically cut these staggering CO2 numbers, by up to 80% and beyond. This is the biggest single leverage we have to fight global warming. The disruptive approach of ROC lies in (1) using H instead of C as reductant and (2) merging the multiple steps explained above into a single melting plus reduction process which can run with green electricity, namely, an electric arc furnace operated with a H-containing reducing plasma. ROC’s approach is feasible as it can be upscaled by modifying existing furnace technology. The motivation is that solid Fe from other synthesis methods such as direct reduction must anyway be melted after reduction. Project ROC also addresses hybrid processes, where partially reduced oxides from direct reduction are fed into a reducing plasma, for high energy and H2 efficiency at fast kinetics and high metallization. Project ROC explores the physical and chemical foundations of these processes, down to atomistic scales, with a blend of instrumented laboratory furnaces, characterization, simulation and machine learning. Specific topics are the elementary nucleation, transport and transformation mechanisms, mixed scrap and ore charging, influence of contaminants from feedstock, plasma parameters, C-free electrodes, slag metallurgy and the role of nanostructure. Drastic reduction of CO2 is the biggest challenge of our time and project ROC explores how steelmaking can contribute to it by cutting its emissions by 80% and more.

Keywords: sustainable ironmaking,green metallurgy,green steel,metallurgy,reduction,co2,sustainable metals,recycling,metallurgical processing,plasma reduction,metal physics,phase transformation
Smart Thermal Metamaterials (STM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: SIGNED

The main goal of this proposal, to propose self-adaptive thermal regulation systems that are smart, green, aesthetically pleasing and engineering applicable, is in line with the RePowerEU plan that efforts in saving energy and decarbonising heat. In this project, new thermal metamaterials are designed that integrates smart radiative cooling, high solar reflectance and customized colour, a multi-function design not previously available. Utilizing the metal-insulator transition of phase changing materials, the thermal metamaterial adapts its thermal emissivity smartly to different ambient temperatures, thus intelligently switching between “on cooling” mode in hot times and “off cooling” mode in cold times, which benefits creating comfortable household conditions and contributing to energy saving from an all-season perspective. Besdies, the thermal metamaterial can present vivid colours to satisfy aesthetic needs. Considering that thermally induced deformation can lead to structural failure of designed thermal metamaterials and affect their working life, mechanical robustness is also considered for scalable production and for real-world applications. A new inverse method is developed to accurately predict the structural deformation by eigenstrain reconstruction. On basis of this, mechanical stability strategy is proposed to eliminate the deformation, which pushes the smart regulation system closer to real-world application. The proposed design is estimated to save at least 134 €/year for a single family in Besançon, Franche-Comté, France. The resulted energy savings not only bring economic benefits but also contribute to environmental preservation and climate change suppression by reducing greenhouse gas emissions. This project can create significant impact in household energy saving and industrial heat management sectors.

Keywords: thermal metamaterial radiative cooling
Controlling particle flow driven by local concentration gradients in geological porous media (TRACE-it)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 1499985.0
EU funding (EUR): 1499985.0
Participants: 2
Project status: SIGNED

Many engineering applications foreseen the usage of small particles for groundwater remediation or for sealing damaged geological confinement barriers, however, delivering materials to a contaminated or damaged region is challenging. TRACE-it aims at controlling the flow of colloidal particles in subsurface geological environments using in situ solute concentration gradients. The phenomenon, known as diffusiophoresis, has a tremendous potential to move colloids to regions that are inaccessible by conventional transport. Diffusiophoretic transport in porous media, however, has received very little attention so far, especially in standard transport in porous media models where it remains unconsidered. What is the magnitude and location of solute concentration gradients produced during subsurface processes? How to use these gradients to transport colloids towards target regions? The answers will be found through a combined experimental-modelling approach to: (i) measure coupled hydro-electro-chemical dynamics, (ii) characterize concentration gradients generated in situ in geological porous media, (iii) identify the influence of concentration gradients on particle transport and develop a macroscale model of transport in porous media that includes diffusiophoresis. TRACE-it integrates the usage of microfluidic experiments, observation techniques, and multi-scale computational fluid dynamics to describe the transport mechanisms at the pore-scale before upscaling to the continuum-scale. The experimental-modelling toolset will open new ways for moving colloidal particles by sensing chemical gradients generated naturally or from human activity, leading them to their target such as oil, contaminants, or reacting minerals. During column-scale experiments, controlling colloid transport will be achieved through the characterization of solute concentration gradients and the use of specifically designed particles.

Keywords: porous media microfluidics colloid pore scale hydro electro chemical coupling
Global Adaptation of soil Microbes under Environmental Change (GAMEchange)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 1499775.0
EU funding (EUR): 1499775.0
Participants: 1
Project status: SIGNED

The representation of soil carbon in models used by the Intergovernmental Panel on Climate Change (IPCC) remains significantly underdeveloped, leading to uncertainty concerning some models predicting soils as carbon sinks and others as sources of carbon dioxide. The development of microbe-explicit models is a very promising avenue for avoiding such inconsistencies and obtaining more accurate soil organic carbon (SOC) predictions. However, these models still suffer from uncertain parameterization due to the lack of data and the high variability in microbial responses at the ecosystem scale. These issues are especially true in carbon-rich northern high-latitude soils that are most vulnerable to large SOC loss with global change. The variability in microbial response at the ecosystem scale is rooted in intricate microscale eco-evolutionary adaptive processes, namely evolution, dispersal, and filtering of community diversity. The diversity in microbiomes, resulting from past selection, influences present adaptive capacity and is referred to as the contingency effect. The GAMEchange project will harness a recent surge of novel microbial genomic data in order to parameterize a new generation of biogeochemical model that accounts for the effect of microbial adaptation on SOC, including contingency effects. GAMEchange will couple the genome-parameterized microscale microbial model with a vegetation land model using a novel emulation approach. This novel coupled model will allow us to compare the 2100 SOC predictions with and without microbial adaptation. This project will produce the first coupled soil microbe-land model parameterized with genomic data, laying the foundation for more realistic microbial models for IPCC climate projections.

Keywords: global carbon cycling,soil microbes,ecology and evolution,land models
BIOBASED PYRAZINE MONOMERS FROM SECOND GENERATION BIOMASS FOR HIGH PERFORMANCE POLYMERS, COPOLYMERS AND BLENDS (BIOPYRANIA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Research and Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Netherlands,Belgium,Spain,France,Germany,Israel,Italy,Estonia,Greece
Call: Development of novel, high-performance bio-based polymers and co-polymers (HORIZON-JU-CBE-2023, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 4999785.0
EU funding (EUR): 4999785.0
Participants: 13
Project status: SIGNED

The Sustainable Product Initiative sets a challenge for European industries to create sustainable products, considering environmental impact, durability, recyclability, and safety. BIOPYRANIA introduces a groundbreaking approach using a new class of biobased pyrazine monomers. They will be synthesized from glutamic acid and 5-amino levulinic acid that are on their turn obtained via fermentative processes starting from European, second generation woody biomass. As already proven by the recent work on pyrazine based polyesters in the labs of Maastricht University, the incorporation of pyrazines gives unprecedented properties, including the potential for added chemical functionality and improved material characteristics through non-traditional hydrogen bonding. BIOPYRANIA will use this knowledge to develop new classes of pyrazine based polyamide and polybenzimidazole polymers, copolymers, and blends in a safe and sustainable way from lab to pilot scale. These pyrazine-based materials have the potential to revolutionize high-performance applications, with a focus on the automotive and green hydrogen sectors. With the electrification of the automotive industry, lightweight, high-performance materials are more and more crucial, and BIOPYRANIA polyamides are promising candidates. In the green energy market, there is a growing demand for clean hydrogen production. Electrolyzers and fuel cells play a key role in this process, and BIOPYRANIA aims to enhance the performance and sustainability of anion exchange membranes that are used therein with pyrazine based polybenzimidazoles. Recycling of these materials will enhance their circularity profile. The developments will be supported and accelerated by digital methodologies, environmental, toxicological, techno-economic and social impact studies. The BIOPYRANIA consortium is a robust partnership of 2 ACAs, 2 RTOs, 7 SMEs, and 2 industrial partners.

Keywords: biobased polymer,pyrazine,polyamide,polybenzimidazole,recycling,unprecedented properties