Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
AdaPtive micROfluidic- and nano-enabled smart systems for waTEr qUality Sensing (PROTEUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: A new generation of components and systems: Engineering of advanced embedded and energy and resource efficient components and systems
Action type: Research and Innovation actions
Countries involved: Italy,Greece,France,France,France,France,France,Portugal,Portugal
Call: Smart System Integration (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 3993520.0
EU funding (EUR): 3993520.0
Participants: 11
Project status: CLOSED

Water management requires massive, low-cost monitoring means coping with differentiated and evolving requirements. However, the majority of multifunctional water sensors only supports predefined goals hindering interoperability, with a high cost, impeding large scale deployments. Addressing this, PROTEUS aims at offering x10 reduction in both size and unit function cost compared to state of the art. To this end, an increased number of functions will be integrated at a reduced cost and PROTEUS will deliver a reconfigurable microfluidic-and nano-enabled sensor platform for cognitive water quality monitoring. Innovative embedded software will provide reconfigurability of the sensing board to support several differentiated applicative goals while cognitive capabilities will manage evolving requirements during exploitation. Energy autonomy will be made by harvesting water flow energy. In addition, low cost of additional sensing components will enable redundancy increasing life span of the systems. The main challenge relates to the heterogeneous integration into a monolithic, microfluidic sensing chip of carbon-nanotubes-based resistive chemical sensors, of MEMS physical and rheological resistive sensors and of a multifunctional adaptive deep-submicron CMOS system on chip. Upstream, high level system design addressing industrial use cases, manufacturability and cost-effectiveness, packaging, energy budget and interfaces between building blocks, will enable consistency and efficiency of the whole approach. Downstream, system validation will be carried out at different levels: benchmarking, reliability assessment to guarantee service time, model deployments and field testing. The consortium brings together renowned actors along the whole value chain, including system integration and end users. This will contribute to post-project exploitation prepared by ensuring appropriate inclusion of business requirements within the system design.

Keywords: multi parametric sensing,water monitoring,cognitive,reconfigurable,mems,micro fluidic cnt array,energy autonomy
Redirecting glial progenitor fate to rebuild the injured Brain (REBUILDCNS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-06-01
End date: 2023-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Over a million different cell types and billions of connections underlie brain function. While the embryonic brain glial progenitors generate this cellular diversity, in the adult brain progenitor competence becomes restricted to generation of few cell types. Thus, any attempt to repair the brain requires knowledge of the rules governing fate decisions within a damaged environment. We have shown that injury activates an inflammatory transcriptional signature in glial progenitors leading to exit from a dormant state. Excitingly, our recent data indicates that injury leads to demethylation of developmental enhancers in these glial progenitors too. In the regenerating zebrafish, activation of enhancers drives a transcriptional regenerative program. Yet, in rodents, despite enhancer demethylation by injury, transcription of a developmental program is missing. The overall goal of this project is to envisage ways to efficiently commission enhancers to re-direct lineage choices of glial progenitors towards re-establishing brain function following injury. Recent technological breakthroughs, including clonal lineage tracing, genome editing, and single cell “omics” combined with mouse genetics and injury models will allow (i) analysis of fate choices in the naïve and injured CNS (ii) study of how the chromatin landscape impacts transcriptional modulation of cell identity (iii) to finally design an integrated manipulation of the epigenome, transcriptome and environment for directed brain repair by endogenous progenitors. We follow a multidisciplinary approach combining cutting edge technology in functional genomics, developmental biology and translational research and leverage on a set of cutting-edge experimental platforms established in my lab and validated protocols that have led to exciting preliminary discoveries. We will provide fundamental knowledge on the mechanisms underlying lineage-decisions of CNS progenitors and open new research lines for treating CNS disorder

Keywords: ischemia,clonal analysis,dormant stem cells,interferon,epigenome editing,methylome,single cell rna seq,lineage tfs,injury,neuroinflammation,fate choices,differentiation,regeneration
Social Sciences and Humanities for Advancing Policy in European Energy (SHAPE-ENERGY)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Robust decision making and public engagement
Action type: Coordination and support actions
Countries involved: Germany,Italy,Spain,Belgium,Sweden,Norway,Türkiye,Bulgaria,France,France,Czechia,Netherlands,United Kingdom
Call: European Platform for energy-related Social Sciences and Humanities research (H2020-LCE-2016-ERA, 2016)
Start date: 2017-02-01
End date: 2019-01-31
Duration (months): 24.0
Total project cost (EUR): 1996573.75
EU funding (EUR): 1996573.75
Participants: 14
Project status: CLOSED

SHAPE-ENERGY “Social Sciences and Humanities for Advancing Policy in European Energy” will develop Europe’s expertise in using and applying energy-SSH to accelerate the delivery of Europe’s Energy Union Strategy. Our consortium brings together 7 leading academic partners and 6 highly respected policy, industry and communications practitioners from across the Energy, Social Sciences and Humanities (energy-SSH) research field, to create an innovative and inclusive Platform. Our partners are involved in numerous European energy projects, have extensive, relevant networks in the energy domain, and represent exceptional coverage across SSH disciplines across Europe. These enable us to maximise the impact of our Platform delivery within an intensive 2-year project. SHAPE-ENERGY brings together those who ‘demand’ energy-SSH research and those who ‘supply’ that research to collaborate in ‘shaping’ Europe’s energy future. A key deliverable will be a “2020-2030 research and innovation agenda” to underpin post-Horizon 2020 energy-focused work programmes. It will highlight how energy-SSH can be better embedded into energy policymaking, innovation and research in the next decade. Our SHAPE-ENERGY Platform activities will involve >12,114 stakeholders and begin with scoping activities including: an academic workshop, call for evidence, interviews with business leaders and NGOs, online citizen debates and multi-level policy meetings. We will build on our scoping to then deliver: 18 multi-stakeholder workshops in cities across Europe, an Early Stage Researcher programme, Horizon 2020 sandpits, interdisciplinary think pieces, a research design challenge, and a pan-European conference. Our expert consortium will bring their considerable expertise to overcome difficulties in promoting interdisciplinary and cross-sector working, and reach out to new parts of Europe to create an inclusive, dynamic and open Platform. SHAPE-ENERGY will drive forward Europe’s low carbon energy future.

Keywords: social sciences and humanities,multi stakeholder,energy research,policy and innovation,innovative collaboration methods,platform
Slimming MIcroaLgae Extract : Development of a new highly effective microalgae-based slimming ingredient for nutraceutical applications (SMILE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: France
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2014, 2014)
Start date: 2015-03-01
End date: 2015-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The SMILE project aims at developing a microalgae-based innovative natural marine ingredient with scientifically demonstrated benefits on weight management and metabolism issues. Obesity and overweight concerning 37% of world population in 2013 (The Lancet, 2014) represent major global health challenges causing millions of deaths worldwide. Well integrated comprehensive strategies can contribute to overweight management. Specifically developed bioactive compounds used in food supplements can help people wanting to lose weight. Consumer are looking for safe, effective (scientifically proven), affordable and natural solutions on these issues that represent today an unmet need. Marine environment is full of biological compounds that could represent relevant answers to these needs. Especially, a specific marine carotenoid found in algae, has received a strong and recent interest from the industry as several scientific publications have demonstrated superior efficacy of this molecule in comparison of existing products targeting weight reduction. However, the only available sourcing (a macroalgae) presents several drawbacks such as the presence of micro-pollutants and some sustainability issues. Through an innovative and patented technology, Microphyt produces sustainably and markets unique bioactive compounds extracted from the untapped diversity of microalgae. Microphyt has identified few strains which are difficult to produce in competitors’ systems and that are able to produce high quantities of this specific marine carotenoid. Moreover, our specific process allow the optimal production of this compound combined with PUFAs which exhibit demonstrated synergistic effects on metabolism. In this context SMILE ingredient represents a high added value potential for Microphyt. Phase 1 feasibility study aims at further analyzing IPR and regulatory status of the different strains, releasing a detailed business plan based on market feedback and pursue the scale up of the best selected strain.

Keywords: microalgae,weight management,obesity,natural ingredients,food supplements,fucoxanthin,omega 3,nutraceuticals
Regeneration of Articular Cartilage using Advanced Biomaterials and Printing Technology (ReCaP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Ireland
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-08-01
End date: 2024-07-31
Duration (months): 72.0
Total project cost (EUR): 2999410.0
EU funding (EUR): 2999410.0
Participants: 1
Project status: SIGNED

Adult articular cartilage has a limited capacity for repair and when damaged or injured, experiences a loss of function which leads to joint degeneration and ultimately osteoarthritis. Biomaterials-based treatments have had very limited success due to the complex zonal structure of the articular joint, problems with biomaterial retention at the joint surface and achieving integration with the host tissue while also maintaining load bearing capacity. Stem cell therapies have also failed to live up to significant hype for a number of reasons including the challenges with achieving formation of stable hyaline cartilage which does not undergo hypertrophy. Building on a wealth of experience in the area, we propose a solution. ReCaP will initially overcome the problems with traditional biomaterials approaches by utilising recent advances in the area of advanced manufacturing and 3D printing to develop a 3D printed multi-layered scaffold with pore architecture, mechanical properties and bioactive composition tailored to regenerate articular cartilage, intermediate calcified cartilage and subchondral bone. Following this, and building on internationally recognised pioneering research in the applicant’s lab on scaffold-mediated nanomedicine delivery, this system will be functionalised for the controlled non-viral delivery of nucleic acids (including plasmid DNA and microRNAs) to direct host stem cells to produce stable hyaline cartilage at the joint surface and encourage the rapid formation of vascularised bone in the subchondral region. A new paradigm-shifting surgical procedure will then be applied to allow this system to be anchored to the joint surface while directing host cell infiltration and tissue repair, thus promoting restoration of even large regions of the damaged joint through a joint surfacing approach. The proposed ReCaP platform is thus a paradigm shifting disruptive technology that will revolutionise the way joint injuries are treated.

Keywords: biomaterial,scaffold,manufacturing,cartilage,bone,3d printing,gene delivery,stem cells
ALMA: Human Centric Algebraic Machine Learning (ALMA)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Finland,France,Portugal
Call: FET Proactive: emerging paradigms and communities (H2020-EIC-FETPROACT-2019, 2019)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 3996500.0
EU funding (EUR): 3996500.0
Participants: 9
Project status: SIGNED

Algebraic Machine Learning (AML) has recently been proposed as new learning paradigm that builds upon Abstract Algebra, Model Theory. Unlike other popular learning algorithms, AML is not a statistical method, but it produces generalizing models from semantic embeddings of data into discrete algebraic structures, with the following properties: P1: Is far less sensitive to the statistical characteristics of the training data and does not fit (or even use) parameters P2: Has the potential to seamlessly integrate unstructured and complex information contained in training data, with a formal representation of human knowledge and requirements; P3. Uses internal representations based on discrete sets and graphs, offering a good starting point for generating human understandable, descriptions of what, why and how has been learned P4. Can be implemented in a distributed way that avoids centralized, privacy-invasive collections of large data sets in favor of a collaboration of many local learners at the level of learned partial representations. The aim of the project is to leverage the above properties of AML for a new generation of Interactive, Human-Centric Machine Learning systems., that will: - Reduce bias and prevent discrimination by reducing dependence on statistical properties of training data (P1), integrating human knowledge with constraints (P2), and exploring the how and why of the learning process (P3) - Facilitate trust and reliability by respecting ‘hard’ human-defined constraints in the learning process (P2) and enhancing explainability of the learning process (P3) - Integrate complex ethical constraints into Human-AI systems by going beyond basic bias and discrimination prevention (P2) to interactively shaping the ethics related to the learning process between humans and the AI system (P3) - Facilitate a new distributed, incremental collaborative learning method by going beyond the dominant off-line and centralized data processing approach (P4)

Keywords: human centric algebraic machine learning
All Optical Manipulation of Photonic Metasurfaces for Biophotonic Applications in Microfluidic Environments (AMPHIBIANS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-02-01
End date: 2025-01-31
Duration (months): 72.0
Total project cost (EUR): 1999524.0
EU funding (EUR): 1999524.0
Participants: 1
Project status: SIGNED

The current trend in biophotonics is to try and replicate the same ease and precision that our hands, eyes and ears offer at the macroscopic level, e.g. to hold, observe, squeeze and pull, rotate, cut and probe biological specimens in microfluidic environments. The bidding to get closer and closer to the object of interest has prompted the development of extremely advanced manipulation techniques at scales comparable to that of the wavelength of light. However, the fact that the optical beam can only access the microfluidic chip from the narrow aperture of a microscopic objective limits the versatility of the photonic function that can be realized. With this project, the applicant proposes to introduce a new biophotonic platform based on the all optical manipulation of flexible photonic metasurfaces. These artificial two-dimensional materials have virtually arbitrary photonic responses and have an intrinsic exceptional mechanical stability. This cross-disciplinary project, bridging photonics, material sciences and biology, will enable the adoption of the most modern and advanced photonic designs in microfluidic environments, with transformative benefits for microscopy and biophotonic applications at the interface of molecular and cell biology.

Keywords: photonic metasurfaces,optical tweezers,microfluidics,biohphotonics
Research And Development with Ion Beams – Advancing Technology in Europe (RADIATE)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Italy,Italy,Germany,Switzerland,Belgium,Finland,Hungary,Sweden,Croatia,Slovenia,France,France,United Kingdom,Portugal,United Kingdom
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2018-1, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 9999669.24
EU funding (EUR): 9999669.24
Participants: 21
Project status: SIGNED

Fifteen partners from public research and four industrial partners, sharing the vision of structuring the ERA in the field of ion technology application and innovation, join forces in the RADIATE project. Largely com-plementary national ion beam facilities will be integrated into one single virtual multi-sited ion beam centre providing unprecedented research capabilities for scientists from a large variety of different re-search fields and from anywhere in Europe and beyond. New challenges arising from the commitment of the EU to Open science, Open innovation and Open to the world will be tackled. To this end an Ion Beam Web Portal will be developed and will serve as pivotal platform for sharing information and software among researchers and for access to ion beam-related databases and to research data. Combining the consortia of the previous successful EU projects ITS LEIF and SPIRIT incorporating leading high and low energy ion beam labs, and integrating top-notch AMS facilities, a comprehensive, easy, flexible, and efficient access to Europe’s key ion beam facilities will be provided. Users from Widening Countries and from new research communities, and young researchers are targeted by a dedicated guest researcher programme. Innovation managers will be established at selected facilities to raise awareness of the exploitation potential of ion beam technology, to support the technology transfer along the whole value chain, and to spin-off commercial activities. Reach-through to industry will be enhanced and self-sustainability of the network and its provisions will be achieved based on the economic success associat-ed with the growth of industrial service and technology transfer activities. Joint Research activities involving the industrial partners will target specific challenges for major advances across multiple subfields of ion beam science and technology, thus reinforcing Europe’s leading position in ion beam science and technology.

Keywords: analytical facilities,ion beams,multidisciplinary research,materials modification,materials analysis,ion implantation,accelerator mass spectrometry,simulation software,technology transfer