Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Building a community of railway scientific researchers and academia for ERJU and enabling a network of PhDs (academia teaming with industry) (Academics4Rail)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Europe's Rail
Action type: Research and Innovation actions
Partnership: EU-RAIL (JU-JTI)
Countries involved: Germany,Croatia,Poland,Serbia,Greece,Spain,France,Sweden,Italy,Switzerland,United Kingdom,Czechia,Slovenia,Lithuania,Slovakia
Call: Building a community of scientific research and and enabling a network of PhD (academia teaming with industry) (HORIZON-ER-JU-2022-02, 2022)
Start date: 2023-09-01
End date: 2027-02-28
Duration (months): 42.0
Total project cost (EUR): 1807237.5
EU funding (EUR): 1807237.5
Participants: 25
Project status: SIGNED

Academics4Rail is an stable and durable scientific community that in an organized way can share and exchange scientific knowledge with ERJU and ERRAC. This knowledge is shared at different levels (strategic to concrete technical areas) and for different purposes. When it comes to the strategic level the scientific community intends to share knowledge with ERRAC and ERJU with the purpose of optimise the program for railway research providing insights of fund use, existing themes for research and scientific necessities for the future of European railways. It also supports the methodology of program assessment using KPIs and impact estimation towards the objectives set out in the ERJU masterplan. Finally, the scientific community shares its knowledge about necessities of future PhD funding with a relevant European and scientific weight. In a more concrete technological domain, the scientific community engages in specific themes creating 6 PhD positions that will enlarge the knowledge in 6 specific areas and will enable the cooperation of academia with industry. The areas are: PhD1 Aerodynamics of freight trains. PhD2 Electromagnetic compatibility. PhD3 Additive Manufacturing in wheel reprofiling. PhD4 Digital communications for virtual coupling. PhD5 Prognostics and health management approach for railway asset maintenance. PhD6 Driving assistance.

Keywords: scientific community for rail research,phd,aerodynamics,electromagnetic compatibility,communications for virtual coupling,driving assistance,assets maintenance,wheel reprofiling
PROTESTING THE GLOBAL AIR TRANSPORT INDUSTRY: SOCIAL MOVEMENTS FIGHTING FOR THE PRESERVATION OF LOCAL COMMUNITIES AND THE PLANET (PROTEST-AIRT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: CLOSED

PROTEST-AIRT is a multi-actor and inter-scalar research project aiming at understanding the growing global and European dissent against the air transport industry. Before the pandemic, air transport was expected to growth at a rate of about 4% per year, including both more frequent flyers in developed nations and new markets in the 'developing' world. This future demand was paired with new infrastructural projects, namely new airports and airport expansions. Recently, several social movements have been campaigning in Europe to create awareness about the series of 'side effects' associated to this global industry, from aircraft noise to CO2 and non-CO2 emissions. Airports have become both the site and objects of diverse forms of dissent. As sites of dissent, airports have been the place where activists congregate and exert their democratic rights through claim-making, oftentimes engaging in 'radical' and performative protest acts. As object of dissent, the narratives about airports and airlines as spaces/companies of interconnection and development have been challenged by these dissenting citizens, proposing alternative readings of airports and airlines as spaces of destruction and overconsumption. The PROTEST-AIRT project focuses on selected cases of European activism that target the global air transport industry, including collectives such as SchipholWatch in the Netherlands, Am Boden Bleiben in Germany, Extinction Rebellion in United Kingdom, Zeroport in Spain and the umbrella organization Stay Grounded, which connects action groups from all over the world. PROTEST-AIRT will be based on media texts, in-depth interviews, visual documentation of acts of dissent through participant observation, analysis of social media data (in specific of Twitter as political platform) and secondary literature produced by airports, airlines and social movements alike. The project will study the ongoing debate apropos potential solutions for the aviation industry and their limits.

Keywords: social movements,civil disobedience,democratic disobedience,online activism,media studies,public sphere,aviation,airports,environmental crisis,mass transport,technology,climate change
Engineering of low germination stimulant production to control witchweed infection in maize in Sub-Saharan Africa (LGSMAIZE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands,Mexico
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-09-01
End date: 2025-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

The parasitic witchweeds, such as Striga hermonthica and Striga asiatica, pose an enormous threat for production of cereal crops, such as sorghum, millet and maize, in the African continent, threatening the livelihood of millions of people, especially in sub-Saharan Africa. Striga seeds lay dormant in the soil until their germination is triggered by strigolactones (SLs), signaling compounds exuded by roots of plants, including maize. Maize exudes at least six different SLs from its roots into the rhizosphere, two of which were structurally identified as zealactone and zeapyranolactone. In work on maize strigolactone biosynthesis that was part of the ERC Advanced grant CHEMCOMRHIZO we demonstrated that there is natural variation in the germination stimulant composition in the root exudate of maize varieties and that this results in a degree of Striga resistance. We have elucidated the entire biosynthetic pathway of all SLs in maize and we showed that the difference in strigolactone composition is the result of a difference in the expression of one of the genes in the pathway. The line with the strongest reduction in the expression of this gene, a North-American cultivar, displays almost full Striga resistance compared with a susceptible control. In collaboration with the CGIAR institute CIMMYT, we propose to create knock-out lines in this gene in two elite African maize varieties to deliver the proof-of-concept that this Striga resistance can be introduced into Africa.
Silicon solar cells with Low Environmental footprint and Advanced interfaces (SiLEAN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Belgium,Netherlands,Switzerland,Italy,Türkiye
Call: Advanced concepts for crystalline Silicon technology (HORIZON-CL5-2023-D3-02, 2023)
Start date: 2024-05-01
End date: 2027-04-30
Duration (months): 36.0
Total project cost (EUR): 3379462.5
EU funding (EUR): 3379462.5
Participants: 9
Project status: SIGNED

The SiLEAN project, involving 2 research institutes, one University partner, 4 SMEs and 1 industry partner, deals with the development of advanced innovations to tackle the major drawbacks of silicon heterojunction solar cell technology, namely the high energy and material demand for Si wafer manufacturing, limited current generation, and the consumption of scarce materials like silver, bismuth and indium. Within the scope of the project, we will directly grow the wafers from the gas phase with low temperature processes, apply alternative passivation concepts that show higher optical transparency, develop indium-free contact layers and apply silver and bismuth-free metallization with all-in-one cell interconnection and encapsulation. We aim to achieve >25.5% solar cell efficiency and >23.5% module efficiency with 50% lower costs for Si wafers and contacting, as well as up to 75% lower carbon footprint. All processes applied allow upscaling to larger sizes as well as high manufacturing throughput. Eventually, the developments of SiLEAN will pave the way for a new, lean, generation of heterojunction solar cell technology that will both increment the energy conversion efficiency and unlock production at terawatt-scale.

Keywords: silicon carbide,transition metal,heterojunction,shj solar cells,epitaxial wafers,metal free,low environmental impact,nanotexture,mini modules
Development and demonstration of zero-emission propulsion technology on board ships using green hydrogen from liquid organic hydrogen carrier in combination with fuel cells at MW-scale (SHIP-AH2OY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Partnership: ZEWT (co-programmed)
Countries involved: Finland,Norway,Germany,Greece,Cyprus,Spain
Call: Enabling the full integration of very high power fuel cells in ship design using co-generation and combined cycle solutions for increased efficiency with multiple fuels (ZEWT Partnership) (HORIZON-CL5-2021-D5-01, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 14999513.26
EU funding (EUR): 14999509.0
Participants: 20
Project status: SUSPENDED

SHIP-AH2OY project will develop a scalable, green and sustainable technology for power and heat generation on board ships. The concept is based on the combined use of hydrogen fuel cells (FC) and liquid organic hydrogen carrier (LOHC) with efficient heat integration. The developed FC/LOHC powertrain will be demonstrated on board a vessel Edda Brint owned by Ostensjo. The SHIP-AH2OY project aims to achieve the following high-level targets: 1. Use of LOHC as the hydrogen storage technology to allow use of existing infrastructure (transport, bunkering, etc) 2. Integration of the hydrogen power unit on board an existing and available ship and the demonstration of the efficient operation of the power plant using green hydrogen. 3. Scalable system architecture for larger ships and power plants by integrating several 1 MW FC/LOHC modules enabling power requirements well in excess of 3 MW. 4. A replication study for the developed FC/LOHC system allowing easy replication in e.g. service vessels and ROPAX-vessels. Basis of the project is the strong commitment of the wide range of industry partners to realize zero-emission shipping. The partners have an already pre-prepared vessel earmarked for the project and plans to retrofit several other vessels with FC/LOHC systems after the first successful demonstration of the technology. As the consortium covers the whole value chain from design-offices and class-society to ship builders, owners and operators, efficient dissemination and exploitation of the results will be a natural outcome of the project.

Keywords: solid oxide fuel cells,liquid organic hydrogen carrier,heat integration
cryo-EM structures of a Gram-positive type 4 secretion system (Cryo-GraPoTSS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-04-22
End date: 2028-04-21
Duration (months): 24.0
Total project cost (EUR): 236340.0
EU funding (EUR): 236340.0
Participants: 1
Project status: SIGNED

Gram-positive (G+) bacteria, such as the Enterococcus species faecium and faecalis, cause around half of hospital-acquired infections. These infections are increasingly antimicrobial-resistant (AMR), which presents a major challenge for tackling the global burden of disease. AMR arises from mutant genes, which can be inherited, and also spread between bacterial species by conjugation through type 4 secretion systems (T4SS), which are protein complex. T4SS are an attractive target for new antibioitics, but development has proven difficult without detailed structural information on these molecular machines. Information is especially lacking for G+ species, which we will address. This project will use cryogenic electron microscopy and tomography to study the T4SS of E. faecalis and obtain the first high-resolution and in situ structures of any G+ T4SS, combining my experience with the cryo-EM of membrane protein complexes and the host’s expertise in G+ T4SS. We will reveal the molecular architecture of a critical conjugation machine and its network of protein-protein interactions. This will enable the precise mechanism of gene transfer and essential (targetable) proteins to be determined.

Keywords: cryo em,tomography,gram positive bacteria,membrane proteins,dna transporters
Linking genome variation with haplotype-resolved sequencing (HAPLOTAGGING)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-05-01
End date: 2023-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

DNA sequencing has transformed biological research, and is fast becoming the standard-of-care in medicine. Chances are good that every European person born today may have their genome sequenced at some point in their lifetime (it is already happening in Iceland). The currently prevailing sequencing platform, Illumina short-read sequencing, prioritizes content (DNA basepairs) over preserving long-range haplotype context. This decision has paid off so far, but comes at the cost of complicated analyses and often lead to undetected disease-causing chromosome rearrangements. Alternative “long-read” technologies, however, have yet to deliver the scale and throughput to truly take over from Illumina sequencing. To meet the grand challenge of sequencing humanity and biodiversity, we need both content and context. As part of our ERC StG action, we have invented haplotagging, a technique that restores haplotype context while integrating seamlessly into Illumina sequencing. We have previously published a small-scale pilot study that haplotagging can deliver superior results at a fraction of existing costs. In doing so our team have solved a series of molecular engineering and computational challenges that have stumped far larger parties. However, our prototype dataset are still not large enough to fully allay concerns from potential licensees regarding robust scalability. Thus, we propose to generate a mid-scale, 2000-sample pilot with direct support from Illumina to provide additional benchmark data, guide scale-up efforts and inform decision-making by industry and academic stakeholders. We expect this proposal will help transition haplotagging from a research concept towards the market.
High-resolution weather observations East of Dakar (DakE) (DakE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-07-01
End date: 2025-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

High-resolution automatic weather monitoring system east of Dakar (DakE) will probe the internal structure and dynamics of tropical mesoscale convective systems (MCS) and design a novel methodology for flood and storm early warning.
Fatigue life assessment of additively manufactured material through a hybrid framework (FLAME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,United Kingdom
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 2
Project status: SIGNED

Additive manufacturing (AM) has been proven as a likely potential alternative to conventional manufacturing methods as it is able to reduce the global environmental impact of many industrial products. One of the main obstacles that prevent AM from expanding its application towards fulfilling the requisites of sustainability and green manufacturing, is poor fatigue resistance of AM material caused by multiple intrinsic surface and internal defects. Currently, different post-processing treatments are being used to tackle this challenge by enhancing surface regularity and reducing bulk defects. Despite the enhancement of fatigue resistance after the aforementioned treatments, these are additional steps that result in longer production times and higher costs. Moreover, due to the complexity of geometry and size, sometimes AM components cannot be easily post-processed by regular treatments. Optimizing the AM processes aiming at maximized fatigue life is a plausible solution that significantly minimizes the need for post-processing. However, the main barrier here is the lack of accurate, fast, and economic prediction tools to correlate fatigue life directly to AM process parameters. FLAME will address the aforementioned needs and pave the way towards efficient fatigue life assessment of AM via developing a hybrid framework through the association of physics-based models and machine learning approaches. It will improve the state-of-the-art fatigue life prediction accuracy from 75% to 90%, making them more economical by eliminating experiments and fast with an implementation time of less than 1 minute. FLAME, through its aforementioned performance, will effectively maximize the fatigue life at the design stage which results in a reduction of post-processing demand and a decrease in production costs. Moreover, it boosts the advancement of AM technology to replace the conventional methods paving the path to sustainable manufacturing and minimizing environmental impacts.

Keywords: additive manufacturing fatigue surface integrity simulation
How do tetraspanin proteins organize, shape, and remodel biological membranes? (ReMembrane)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 1495625.0
EU funding (EUR): 1495625.0
Participants: 1
Project status: SIGNED

Our bodies rely on protein driven shaping and remodelling of our cells’ membranes to function. Uncovering the mechanisms of remodelling of the cell membrane is, therefore, essential for understanding biological processes such as fertilization, but also to allow for precise intervention in them when needed. The interplay between protein position, membrane tension, and local curvature is believed to dictate these processes. However, experimental verifications of this hypothesis in specific biological systems are scarce. Here, I propose to apply my expertise in the characterization of mechanical properties and remodelling of membranes to obtain ground-breaking quantitative details of the shaping and remodelling mechanisms in which the Tetraspanin (TSPN) family of proteins are involved. TSPNs provide an ideal case study for several reasons, they are of extreme importance to biological processes such as viral infection, they are well characterized by biochemical, genetic and proteomics approaches, and their mode of action is suspected to depend on membrane tension and curvature. Of specific interest is the role of TSPN in the formation of the newly discovered cellular organelles, called migrasomes, which are a new cell-cell communication paradigm. This proposed project addresses TSPN functions by a bottom-up approach, reconstituting the processes of interest from simple building blocks and characterizing the distinguished roles of membrane tension and curvature. To this end we will use several new assays based on combined optical tweezers, micropipette aspiration and confocal microscopy as well as AFM that will operate on crafted membrane model systems. Our unique experimental approach will allow us to recreate the conditions leading to migrasome formation, egg-sperm, and viral membrane fusion. Revealing the mechanisms underlying these processes will have direct impact on the development of infertility treatments, non-hormonal contraceptives, and novel anti-viral drugs.

Keywords: membrane biophysics,membrane physical chemistry,membrane fusion,membrane remodeling,optical tweezers