Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Finding the Lost Library: Hernando Colón's Dispersed Books Worldwide (FILOL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2025-01-31
Duration (months): 28.0
Total project cost (EUR): 232879.67
EU funding (EUR): 232879.67
Participants: 1
Project status: CLOSED

The overarching aim of the FILOL project is to track down for the first time the dispersed books from Hernando Colón’s “Universal Library”. In the early 16th century, Hernando Colón (1488-1539) established in Seville the first documentation centre in the Western world, in which he aimed to gather copies of “every book on every subject in every language”. Almost the entirety of his collection was comprised of printed books. Unlike other Renaissance intellectuals, Colón collected not only fine editions but also the products of popular publishing, such as pamphlets, almanacs and other ephemera. Colón’s library was, therefore, the first official repository of the written products of what was considered universal culture, destined in most cases to disappear precisely because of their physical fragility. To manage the 15,000 books he collected, Colón designed a revolutionary system of cross-referenced catalogues relating to the authors, subjects, extracts and summaries of his volumes. After Colón’s death, most of his books were dispersed, and today only about 4,000 volumes from his original collection survive in the Biblioteca Colombina in Seville. In addition to extensive losses immediately following Colón’s death, books continued to go missing from the BC into the late 19th century, frequently winding up on the antiquarian book market. The FILOL project will attempt to describe and locate a significant portion of the Universal Library’s dispersed volumes, making them available in a catalogue hosted in the open-access database Book of Books, developed by the team of the UCPH project “Hernando Colón’s Book of Books”. This will be accomplished through a cross-reference examination of the complete set of Colón’s library catalogues and an innovative research methodology focused on the analysis of the antiquarian book market’s bibliographic tools to track the mobility of early printed books in the modern and contemporary age.

Keywords: book history,dispersed libraries,book trade,book collecting,book mobility,library history,knowledge mobility
Elucidating the role of biomolecular condensation in meiotic DNA double-strand break formation (MeioticCondensate)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-07-01
End date: 2029-06-30
Duration (months): 60.0
Total project cost (EUR): 1998750.0
EU funding (EUR): 1998750.0
Participants: 1
Project status: SIGNED

Meiosis universally relies on the formation of DNA double-strand breaks (DSB) to initiate a genome-wide recombination program that promotes genetic diversity and is required to produce chromosomally-balanced haploid gametes. DSB formation is catalyzed by Spo11, which in acts in conjunction with nine essential partners in yeast, including the RMM proteins. We previously found that RMM undergoes DNA-dependent condensation, and proposed that this organizes intracellular sub-compartments within which controlled DSB formation takes place. The RMM proteins connect DSB formation to chromosome structure, and are subject to overlapping regulatory pathways that control the timing, position, and number of DSBs. However, the molecular assemblies that catalyze DSB formation and the mechanisms whereby they are regulated remain poorly understood. Here, I propose an approach that takes advantage of our established biochemical and molecular genetics techniques, combined with the development of novel methodologies, to unravel the central role of RMM condensation in DSB formation. Specifically, we will address the following outstanding questions: (1) What are the mechanisms of post-translational control of RMM condensation? (2) How does transcription impact condensation and DSB formation? (3) How does the chromosome axis affect RMM condensation? (4) What are the quantitative molecular interactions that underlie condensation? (5) Which proteins associate with RMM condensates? (6) What is the impact of RMM condensation on chromatin structure? This proposal harnesses our current knowledge of the molecular properties of DSB proteins to explore new models and hypotheses regarding the relationships between the DSB machinery and the cell. My goal is to gain insights into the molecular processes that underlie genetic inheritance. In addition, this work will contribute to our understanding of the role of biomolecular condensation as an organizing principle of cellular structure and function.

Keywords: meiosis,dna recombination,phase separation,protein interaction,phosphorylation,atomic force microscopy,interactomics,chromatin structure,saccharomyces cerevisiae
NET ZERO PATHWAY RESEARCH THROUGH INTEGRATED ASSESSMENT MODEL ADVANCEMENTS (PRISMA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Austria,Netherlands,Greece,France,United Kingdom,Switzerland,Belgium,Poland
Call: Improvement of Integrated Assessment Models in support of climate policies (HORIZON-CL5-2022-D1-02, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 4457810.0
EU funding (EUR): 4457809.5
Participants: 16
Project status: SIGNED

The ambition to achieve the Paris Agreement goals has led to the realization that a rapid and full decarbonization of the economy is required, involving a structural transition of the current economy and society. With the rise of quantified policy targets, policy packages, and consideration of multiple dimensions and sectors, Integrated Assessment Models with their ability to consider complex relationships and provide calibrated numerical results have become ever more important in the last decade. The PRISMA project aims to bring these models to the next level by focusing on four key areas of improvement, namely the representation of distributional justice and efficiency, innovation and finance, climate impacts and land-use implications, and lifestyle change and circularity. In these four key areas we will improve existing large-scale IAMs and sectorial models, and consider the linking of different models where applicable. Two cross-cutting shared themes across these areas are the improvement of the temporal and spatial resolution of the analysis, and the representation of disruptive and structural change in the economy. Notably we will increase the spatial granularity with a focus on Europe, and look at the yearly and in particular near term detailed modeling of rapid decarbonization pathways. The extensive model development will be co-designed through an interactive stakeholder engagement process from the beginning, and focus on model openness and usability to ensure the stakeholder and policy relevance. Moreover, PRISMA will focus in its application on the analysis of the spectrum of Fit for 55 package policies of the EU developing focalized robust and resilient Net zero pathways and assess the uncertainty around key variables and outcomes. PRISMA will also provide key insights to international climate assessments, a large number of open modelling tools and databases, including capacity building and dissemination activities for all countries.

Keywords: climate change,climate policy,fit for 55,intergated assessment models,finance,structural change,heterodox models,
A Strategic Roadmap Towards the Next Level of Intelligent, Sustainable and Human-Centred SMEs (SME 5.0)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Austria,Slovakia,Malta,Sweden,Germany,Australia,United States,Argentina,Thailand,South Africa
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 1174314.29
EU funding (EUR): 1168400.0
Participants: 16
Project status: SIGNED

Over the last ten years many efforts have been made to transfer Industry 4.0 from research to practice. Recently, great progress has been made to introduce also SMEs to the use of Industry 4.0. The next big challenge for SMEs will be to implement the dual (or twin) transformation in sense of a digital transformation towards more intelligent manufacturing, while tackling and accelerating the sustainability transformation to enhance economically, socially and environmentally sustainable processes, factories and value chains. In this project we aim to take SMEs to this next level by developing a Strategic Roadmap for making them not only intelligent but also sustainable, resilient and human-centric. This next level of SMEs will be data and intelligence-driven, thus using available data to acquire new knowledge and to apply it for optimization purposes using artificial intelligence in a secure way. Further, a great attention is paid to how manufacturing and value chains in SMEs can become more circular, green and resilient by considering ethical, human and societal values for more socio-centred factories. In this next level of SME 5.0 factories the human will play a much more important, albeit changing, role. Besides identifying emerging future work profiles and competencies of SME employees, we will develop guidelines for rendering SME workplaces in industry more inclusive and diverse and for empowering them for increased well-being and attractiveness of SME jobs. The main outcome of the project is to develop and propose a Strategic Guideline and Roadmap that will facilitate SMEs in Europe and worldwide to achieve the above mentioned goals. To expand the impact and exploitation an SME 5.0 Stakeholder & Training Network will be build. The applicability of the results and guidelines is ensured through a close collaboration with non-academic partners, SMEs in the partner network and the aim to validate the results through demonstrators and case study research.

Keywords: industry 5 0 society 5 0 human centred manufacturing small medium sized enterprises intelligent manufacturing diversity sustainable production resilience operator 4 0 ethics in manufacturing
A novel, rechargeable neuromuscular electrostimulation Smart Geko Device to treat and prevent diabetic foot ulcers (DFU) (SGD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2291142.0
EU funding (EUR): 2291142.0
Participants: 1
Project status: SIGNED

Sky will develop a revolutionary non-invasive, wireless, rechargeable neuromuscular electrical stimulation Smart Geko device (SGD) & a safe conductive skin adhesive to facilitate the treatment and prevention of diabetic foot ulcer (DFU) in clinical and homecare settings. DFU is a common, expensive, and serious complication of diabetes that takes weeks or several months to heal. DFU has become a significant global public health concern that is expected to rise dramatically in line with the staggering projection of diabetes epidemiology over the next decades. The current ineffective and substandard management of DFU leads to infections, resulting in lower-extremity amputation (LEA). Around 85% of diabetes-related LEAs are preceded by a foot ulcer. Existing wound care management methods are expensive, risky and are only focused on reducing the symptomatic burden temporarily by treating the consequences of DFU. The recent novel treatments that have become available to treat DFU have shown limited efficacy and needs clinical validation. Globally, the risk of DFU recurrence is 50%, implying the need for efficient preventive strategies. There is therefore a global unmet medical need to develop a safe and cost-effective treatment and prophylaxis for DFU. Sky’s SGD treatment will represent a novel and advanced approach to accelerate wound healing by restoring the underlying microcirculatory dysfunction that drives DFU. The clinical benefits of the device’s cutting-edge technology have been demonstrated in independent clinical studies involving relevant patient populations. The SGD treatment will offer the potential to prevent the progression of DFU to life threatening and expensive complications including LEAs. It can act as a prophylactic to prevent the DFU reoccurrence and ultimately be used to reduce its first-onset among high-risk patient groups. This will massively decrease the financial and healthcare burden on the patient families and healthcare system worldwide.

Keywords: diabetic foot ulcer,ischemia,microcirculation,diabetes,patient care,personalised treatment,amputation,wellbeing,circular economy,neuromuscular electrical stimulation,wound care treatment
Joint Communication and Sensing in 6G Networks (6thSense)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium,Netherlands,Spain,Italy,Finland,Germany,Türkiye,United Kingdom,United States
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-02-01
End date: 2028-01-31
Duration (months): 48.0
Total project cost (EUR): 2869869.43
EU funding (EUR): 2635429.2
Participants: 20
Project status: SIGNED

Having lost a significant share of the market to big players from the US and Asia, Europe is no longer at the forefront of the telecommunication industry. However, new services focusing on remote health monitoring, industry 4.0, and autonomous vehicles have created a unique opportunity for Europe to regain a leading position in 6G. Unlike traditional mobile broadband that mainly connect people, these emerging services not only exchange data but also critically rely on accurate information from their surroundings (i.e., sensing). Consequently, joint communication and sensing (JCAS) is a key feature of 6G networks, where devices will embed wireless sensing capabilities (e.g., localisation, activity recognition). JCAS faces major challenges since it demands fundamental changes to current communication systems. 6thSense follows a holistic approach to address these challenges by: (WP1) Going beyond traditional sub-6GHz systems and enabling sensing in new B5G/6G communication bands, i.e., millimetre-wave and visible light; (WP2) Addressing distributed sensing and networking challenges through architecture and protocol design; (WP3) Handling the analytical complexity of JCAS by combining the strengths of classical signal processing and optimisation models with advanced machine learning techniques; (WP4) Transferring these research contributions to industry-relevant applications in healthcare, manufacturing, and automotive sectors. 6thSense is an intersectoral and interdisciplinary cluster of excellence formed by electrical engineers and computer scientists that has pooled leading members of large EU initiatives (5G PPP), industry leaders (e.g., Nokia, Ford, Bosch) and academic institutions (e.g., KUL, TUDelft, Princeton, UCLA). Benefitting from this consortium, a comprehensive soft-skill training (WP5) and a tailored dissemination and exploitation strategy (WP6), the 10 PhD fellows will become highly employable in various industries, academia, or public government bodies.

Keywords: joint communication and sensing,radar systems,6g communication networks
PREFIGURING DEMOCRATIC FUTURES. CULTURAL AND THEORETICAL RESPONSES TO THE CRISIS OF POLITICAL IMAGINATION (PREDEF)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2430483.0
EU funding (EUR): 2430483.0
Participants: 1
Project status: SIGNED

Democracy is in a crisis of global scale. This crisis has variously been attributed to a loss of belief in political representation, the rising of technocratic ‘post-democracy’, or an authoritarian and populist turn. However, a narrow focus on the political system is inadequate. PREDEF starts from the assumption that the crisis of democracy is also a crisis of political imagination. As the infamous TINA-principle (‘There is no Alternative’) illustrates, it has become increasingly difficult to imagine genuine democratic alternatives to the status quo. PREDEF sets out to explore potentials for deepening and pluralizing democracy beyond the sphere of politics narrowly defined as the body of existing political institutions. The project will turn to the fields of culture, art and intellectual history, for these fields hold hitherto untapped potentials for extending our democratic imaginary and disclosing political alternatives. Located at the intersection between cultural research and democratic theory, PREDEF meets this challenge empirically and theoretically. Empirically, artistic and cultural counter-practices are investigated that champion democratization in the time-based arts (through theatrical occupations), international relations (through counter-summits) and law (through ‘mock’ tribunals). Theoretically, the project seeks to widen our democratic imaginary by searching the history of ideas for ‘forgotten’ institutions that hold untapped democratic potentials, and by elaborating a democratic theory of counter-institutions. The main objectives are: i. regaining a ‘sense of possibility’ in a time of vanishing democratic alternatives, ii. exploring the democratizing potential of cultural and artistic practices and institutions; iii. learning from alternative configurations of the past and beyond the Western context, specifically regarding institutional designs; iv. connecting theoretical and empirical research with the aim of genuine cross-fertilization.

Keywords: democratic theory prefiguration radical democracy
Novel light regimes and drought effects on temperate forest plant biodiversity (CanopyChange)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1999094.0
EU funding (EUR): 1999094.0
Participants: 1
Project status: SIGNED

Tree canopies are one of the most recognizable features of forests, providing shelter from external influences to a myriad of species that live in the understorey. Canopy disturbances are now accelerating across European forests, and climate-change induced drought is a key driver. These disturbances are opening the canopy and exposing forest biodiversity to no-analog light regimes and drought – light and drought levels they have never been exposed to before. As the majority of forest plant species occur in the shade below tree canopies, the combination of altered light regimes and intensifying droughts can strongly impact forest biodiversity. However, the interactive effects of novel light regimes and drought on temperate forest biodiversity have never been investigated before. Since recent European droughts are unprecedented in the last two millennia, and this has initiated the largest pulse of forest disturbances in almost two centuries, the time to assess impacts on biodiversity is now. The overarching aim of CanopyChange is to quantify, understand and predict the impacts of no-analog light regimes and drought on below-canopy forest plant biodiversity. To address this challenging goal, cross-continental resurveyed vegetation plots, the first pan-European forest disturbance-drought experiment, and a pioneering canopy clipping mesocosm experiment will be combined with an interdisciplinary toolbox drawing from ecology, forestry, and climatology. These data will then feed into cutting-edge joint species distribution models to project European forest plant biodiversity responses to future climate and canopy change. CanopyChange will be the first integrative study of pan-European forest plant biodiversity responses to no-analog light regimes and drought. CanopyChange is at the heart of biodiversity conservation and forest management, and will deliver much-needed information for policy makers and managers to adapt to the future, no-analog conditions in European forests.

Keywords: climate change,forest biodiversity,conservation,understorey plants,drought,modelling