Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Securing Adoption of Personalised Health in REgions (SAPHIRE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Coordination and support actions
Countries involved: Germany,Belgium,Netherlands,United Kingdom
Call: Actions in support of the International Consortium for Personalised Medicine (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2018-12-01
End date: 2022-05-31
Duration (months): 42.0
Total project cost (EUR): 1853813.13
EU funding (EUR): 1778813.0
Participants: 4
Project status: CLOSED

SAPHIRE or the consortium for Securing Adoption of Personalised Health in REgions: The consortium eSAPHIRE or the consortium for Securing Adoption of Personalised Health in REgions: The consortium engages to help structuring the application of personalised medicine (PM) at regional level and contribute to the implementation and reach of the International Consortium on Personalised Medicine (ICPerMed) to develop its roadmap and Action Plan, while taken regional specific needs into account. Efforts will be taken to express the regional voice within ICPerMed. The activities will include the establishment and support of networking between regions and interregional cooperation, and in particular linking remote or sparsely populated regions with regions harbouring critical mass of medical and PM expertise, while taking into account broader socio-economic and cultural aspects. The network will cover regional policy and decision makers, opinion leaders, regulatory agencies, regional development agencies, cluster organisations, patient organisations and regional knowledge institutions, healthcare actors, ... and will bring regional strengths, needs and barriers to the attention of national and European level. Based on a thorough mapping exercise and addressing specific regional needs, while taken the different levels of PM adoption into account, a modular regional roadmap for PM implementation will be developed. Actions will be taken to support interregional collaborations in the field of PM and identify opportunities for funding or investment by the framework programme, the structural funds or the EIB, whereby efforts will be taken to link remote and sparsely populated regions to regions that are more advanced in PM implementation. Alignment will also be made to smart specialisation initiatives focussing on PM. The integrated approach of SAPHIRE should accelerate the implementation of PM across the European regions, thereby accelerating the uptake of PM in general.

Keywords: icpermed,personalised health and care,predictive,preventive,stratified,precision medicine,biomedical clusters,regional development,interregional collaboration,smart specialisation
New vaccine for a paradigm shift in Brucellosis, one of the world’s most widespread zoonotic diseases affecting humans (BGV1)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-03-01
End date: 2023-02-28
Duration (months): 36.0
Total project cost (EUR): 2005250.0
EU funding (EUR): 1403675.0
Participants: 1
Project status: TERMINATED

Brucellosis is the world’s most widespread zoonotic disease. It is a global problem but most severely affects poor livestock keepers in the developing world because of its impacts on human and animal health and livelihoods. Brucellosis is endemic in most of Asia, Africa and Latin America and is prevalent in the EU Mediterranean regions. Currently vaccines for Brucellosis, around since the 1950s, suffer from serious safety drawbacks mainly due to residual virulence for animals and humans. Combined with rising antibiotic resistance, their use is relatively limited. GreenVac is developing BGV1, the first vaccine in over 60 years against Brucella melitensis in small ruminants that overcomes the main drawbacks of existing vaccines. BGV1 has been designed to a) be avirulent for animals, b) eliminate interference with diagnostic tests after vaccination, c) have low potential transmissibility to humans and, d) be treatable with standard antibiotics. BGV1 is a strong candidate to replace the classic virulent vaccine, exhibiting a safe profile with an enhanced protective efficacy, no residual virulence and minimal serodiagnostic interference. A successful BGV1 EU-project will allow, for the first time, mass vaccination of any animal at any time (including pregnant and lactating animals), which is a radical paradigm shift in Brucellosis control and eradication. The reduction of B. melitensis outbreaks and infection rate in animals will generate €3.81bn in cumulative economic benefits for users by 2029 by evading unnecessary diagnostics costs and losses caused by the infection. It will lead to a lower disease incidence in humans amidst ever rising globalisation and bioterrorism threats to anyone, anywhere. BGV1 will contribute to the objectives of the One Health Initiative: One World, One Health, One Medicine to improve the lives of all species through the integration of human medicine, veterinary medicine and environmental science.

Keywords: brucellosis,zoonotic disease,livestock,sheep and goats,cattle,veterinary vaccine,avirulent vaccine,massvaccination,low transmissibility
Gender asymmetry in the transmission of Odissi dance in India - a case study (GATRODI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: India,France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2024-06-30
Duration (months): 36.0
Total project cost (EUR): 233808.0
EU funding (EUR): 233808.0
Participants: 2
Project status: SIGNED

Gatrodi is an anthropological study of the practices of Odissi dance in India, considered by the Indian government to be the classical dance from the State of Odisha. Though the dance is practiced by male and female individuals from diverse geographical locations and status groups, it is generally male practitioners from rural areas of Odisha who are recognised as its legitimate transmitters. The women, who generally belong to urban backgrounds, are considered to be the performers of the dance. However, while they do not obtain the same recognition as the men, some women are actually transmitting Odissi. But then, how does their teaching differ from that of the men? In order to shed light on this question, the study will investigate on the modalities of transmission of female practitioners in Odissi in India. The methods of inquiry will consist primarily of observation, and also of video and audio recordings of training situations and interviews. These will be undertaken in selective dance schools in Bhubaneswar, capital city of Odisha, and in a metropolitan city of India as well. Through the above mentioned methodological tools, Gatrodi will produce a detailed ethnographic account of the teaching modalities of the women participating in the study. This shall clarify which methods, be they verbal or non verbal, they implement while transmitting the dance. Consequently, it will be possible to assess which processes are at work in these situations, and how they are related to the social order that prevails in Odissi dance networks. The teaching activities of the women will further be compared to those of the men. In this way, Gatrodi will shed light on the dynamics of transmission of Odissi and the processes of legitimisation of its methods, thereby documenting how, beyond the particular case that is being studied, body practice and social life are interconnected.

Keywords: anthropology dance transmission gender asymmetry india
Ruđer Bošković Institute: Twinning for a step forward of the Theoretical Physics Division (RBI-T-WINNING)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Italy,Croatia,France,Denmark
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-02-01
End date: 2019-01-31
Duration (months): 36.0
Total project cost (EUR): 999987.5
EU funding (EUR): 999987.5
Participants: 5
Project status: CLOSED

Research topics in theoretical physics at Ruđer Bošković Institute (RBI) are broad, from understanding the basic constituents of the Universe, to the study of new materials and complex systems. The research is performed within the Division of Theoretical Physics (DTP), mostly in collaboration with European research institutions. However, the effectiveness and impact is increasingly suffering from a strong limitation of resources, in terms of funding for students, collaboration and dissemination, in addition to the low salaries. In this context, RBI recently made significant efforts to increase its research capabilities in the applied sector, in line with the Smart Specialization Strategy. This is planned through two projects, the major infrastructure project O-ZIP (high priority in the Croatian Operational program for the European Structural Funds) and a recently granted ERA Chair project. Both will impact the theoretical community and call for a rise in its level. RBI-T-WINNING will provide the complementary funding for theoretical physics, with the aim of raising the research profile to that of excellent institutions. This aim will be pursued by supporting strong links with leading European research institutions. Intensive exchange of knowledge and experience will be organized with SISSA, CNRS/University of Paris-Sud Orsay, Ludwig Maximilian University and Niels Bohr Institute, excellent european institutes and altogether cover the investigations within theoretical physics. The set of measures include staff exchanges, training, conferences, summer schools, dissemination and outreach activities for impact on the local community. The project also enables active participation of Croatian researchers in top-level physics research programs, for increasing their experience and visibility. In synergy with other related projects RBI-T-WINNING will maximize the overall impact on the research & innovation potential of Croatia in theoretical physics and overall.

Keywords: theoretical physics
The Elusives Enterprise: Asymmetries of the Invisible Universe (ELUSIVES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Germany,Germany,Spain,Spain,Germany,Italy,Spain,Switzerland,France,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-04-01
End date: 2020-03-31
Duration (months): 48.0
Total project cost (EUR): 3855581.28
EU funding (EUR): 3855581.28
Participants: 12
Project status: CLOSED

NEUTRINOS and DARK MATTER (DM) are the most abundant and also the most elusive building-blocks of nature because of their tenuous couplings to the ordinary matter we are made of. Each particle has a mirror image with identical mass and opposite charge: its antiparticle. What is the essential nature of particles and antiparticles? This is a most fundamental open question in science. The laws of physics are almost -but not quite- symmetric for particles and antiparticles, and this could explain why the universe is made of matter, i.e. why we are here. Tiny differences detected in visible matter are largely insufficient, while an asymmetric behaviour of neutrinos or of DM may be the seed. In turn, the unnaturally symmetric behaviour of strong interactions points to a new particle, the axion, also a superb DM candidate. For the first time, the connection between these asymmetries in the visible and invisible world will be addressed. Very timely, an ambitious experimental search of asymmetric behaviour has been launched on neutrinos, axions and other DM, and the Higgs, with imminent major breakthroughs. The path to understand the Universe and build the New Standard Model must confront this problem. The mission of Elusives ITN is to form the new generation of researchers to accomplish this task, focusing on phenomenology with the necessary link to experiment. This is the first transnational such program, exploiting the capital investment in new experiments and overcoming the fragmentation of the research effort. ELUSIVES ITN is uniquely placed for it: * World-leadership in all relevant areas; * Multidisciplinarity; * Key theorists and experimentalists; * Outstanding training record; * CERN, Fermilab, SuperKamiokande and ADMX partners; * World leading cutting-edge research-related industry; * Highest professional beneficiary dissemination; * Top-quality expertise from emerging countries; * Optimal gender balance with over 50% female international leaders as coordinators.

Keywords: neutrinos dark matter particle antiparticle identity complementarity
Development of the Cyclin-Dependent Kinase Inhibitor VS2-370 to Target HIV-associated Malignancies and to Purge Viral Reservoir (THUNDER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Italy
Call: Dedicated support to biotechnology SMEs closing the gap from lab to market (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-03-01
End date: 2017-07-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

ViroStatics, operating in the biotechnology industry, is developing the innovative drug VS2-370 that targets both HIV-associated cancer and its indirect cause, the viral infection. There is no similar drug, as HIV infection and associated malignancies are presently treated independently, without realizing that they are two sides of the same underlying pathogenetic problem. VS2-370 unique anti-CDK4/6/9 profile not only suppresses HIV, but also limits clonal expansion and induces apoptosis of infected cells, with the potential to purge the viral reservoir. Unlike with currently available antiretroviral therapy (ART) this could lead to a cure of HIV infection (or functional cure, that is to allow long periods of ART-free remission), mirroring the recent success of Hepatitis C cure, and it would similarly open a multi-billion Euro market opportunity. ViroStatics strategy is to develop VS2-370 through the well established pathway of oncology drugs, then to expand the indication to the HIV cure. VS2-370 has reached TRL6 and demonstrated anticancer activity in CDK4/6/9-dependent tumors in relevant in vitro and in vivo models, it has shown good exposure/tolerability profiles, and it has been produced in a GMP lot. After confirming the interest of a Pharma Customer with franchise in Oncology and/or HIV (Phase 1) we will file an Investigational New Drug application and carry out a First in Men (FIM) study through the extensive use of systems biology (Phase 2), thus significantly increasing the value of VS2-370 before out-licencing it to the Pharma Customer. The advantages for the final users (HIV-infected individuals with associated malignancies) will be: tumor- and ART-free remissions, quality of life improvement, decreased side effects associated with ART, cost savings for the patients and the Health Systems.ViroStatics has capital to support its experienced management and to contribute in part to Phase 1 and Phase 2, but needs the SME instrument to complete the FIM study.

Keywords: cure,systems biology,hiv associated tumors
DIMO6FIT: Extending the Standard Model -- Global Fits of Optimal Variables in Diboson Production (DIMO6FIT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2022-07-31
Duration (months): 66.0
Total project cost (EUR): 1497000.0
EU funding (EUR): 1497000.0
Participants: 1
Project status: CLOSED

The status quo of particle physics after the first data taking at the Large Hadron Collider is: a light Higgs particle has been discovered that is perfectly compatible with the electroweak Standard Model (SM). While this is undoubtedly a historic step in particle physics, it is not entirely satisfactory, as in its current state the SM leaves many questions unanswered. If the Standard Model of today is just the low energy theory of more complex phenomena, then these phenomena will become manifest in modifications of the cross sections and differential distributions of known processes. These modifications can be described by higher dimensional operators, which are general extensions of the SM and can be tested using precision measurements of diboson production processes. The DIMO6Fit project will focus on measuring those production processes most sensitive to the new physics effects, using innovative analysis techniques aimed at significantly reducing the debilitating limitations in current measurements. I will set up a novel combined global fit for determining the higher dimensional operators coherently based on the LHC measurements. The full determination of the higher dimensional operators will be the first global precision test of general extensions to the SM. The ERC Starting Grant will make it possible to bring together a team that will conduct more efficient measurements then today at the ATLAS experiment, that will establish the framework for new precision tests, and will generate results of yet unforeseeable potential. With DIMO6FIT I will establish an exciting programme aiming at determining the higher dimensional operators, which will help uncover new physics and elucidate its nature. These novel studies will form a unique and significant contribution to the understanding of the fundamental interactions of known and possibly yet unknown particles.

Keywords: test of the standard model,diboson measurement,electroweak physics,atlas,new physics in precision measurements
Optimised Framework based on Rough Set Theory for Big Data Pre-processing in Certain and Imprecise Contexts (RoSTBiDFramework)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 2
Project status: CLOSED

Over the last decades, the amount of data has increased in an unprecedented rate, leading to a new terminology: "Big Data". Big data are specified by their Volume, Variety, Velocity and by their Veracity/Imprecision. Based on these 4V specificities, it has become difficult to quickly acquire the most useful information from the huge amount of data at hand. Thus, it is necessary to perform data (pre-)processing as a first step. In spite of the existence of many techniques for this task, most of the state-of-the-art methods require additional information for thresholding and are neither able to deal with the big data veracity aspect nor with their computational requirements. This project's overarching aim is to fill these major research gaps with an optimised framework for big data pre-processing in certain and imprecise contexts. Our approach is based on Rough Set Theory (RST) for data pre-processing and Randomised Search Heuristics for optimisation and will be implemented under the Spark MapReduce model. The project combines the expertise of the experienced researcher Dr Zaineb Chelly Dagdia in machine learning, rough set theory and information extraction with the knowledge in optimisation and randomised search heuristics of the supervisor Dr Christine Zarges at the University of Birmingham (UoB). Further expertise is provided by internal and external collaborators from academic and non-academic institutions, namely Prof Tino (UoB), Prof Merelo (University of Granada), Prof Lebbah (University of Paris 13) and Philippe Barra (Arrow Group). The involvement of Arrow Group, an SME based in France specialised in Big data, Banking, Finance & Insurance is of particular importance to ensure that real-world requirements are met throughout the development of the framework.

Keywords: big data,rough set theory,optimization,information extraction,missing values
Understanding the drivers of the genetic and functional structure of deep-sea sponge symbiont communities (DeepSym)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2021-01-28
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Sponges (phylum Porifera) are sessile filter-feeding organisms that dominate the benthos in many regions of the marine environment. They represent the pillars of the ecosystem for the functions and services they provide. Sponges are known for hosting dense, diverse, and highly specific microbial communities that contribute appreciably to the host’s metabolism and biochemical repertoire. Shallow water sponges and their associated microorganisms have received most attention but much less is known about deep-sea sponges, and whether these sponges exhibit contrasting functions and symbiotic relationships as a result of being in an extreme environment. This project aims to determine the next frontier of sponge symbiosis: the functionality of the microbial consortia of deep-sea sponges. Sponge associated microbial communities vary within and among species, and this variation can be attributed to biotic and abiotic factors. The genetic variability and population structure of the host sponge has been suggested as a factor controlling the intraspecific bacterial composition in different locations. This hypothesis has yet to be rigorously tested, particularly examining coexisting species in the same habitat and species widely distributed across latitudinal gradients. I will explore the role of the host genotype in shaping the associated microbial community by examining several individuals of three species of sponges among five geographically segregated regions, including three localities within each region. Genotyping of sponges and analyses of microbial communities will use next generation sequencing technologies of DNA and RNA, providing high-resolution information of host relationships, microbial compositional and functional profiles. This project will constitute a major breakthrough in bridging the gap between evolution and function in multispecies relationships, attracting the interest of a wide variety of fields.