Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deciphering and exploiting ferroptosis regulatory mechanism in cancer (DeciFERR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 1985356.0
EU funding (EUR): 1985356.0
Participants: 1
Project status: SIGNED

Ferroptosis is a cell death modality triggered by the accumulation of oxidised lipids, a process known as lipid oxidation, and associated with a multitude of pathological conditions, including ageing, neurodegeneration, and cancer. On the flip side, recent studies demonstrated that targeting pathways contributing to the prevention or repair of oxidised lipids is a powerful strategy to eradicate therapeutically challenging entities, including neuroblastoma, a pediatric malignancy reported to be remarkably sensitive to ferroptosis. However, therapeutic breakthroughs targeting this pathway are elusive due to our incomplete understanding of the factors controlling this process. DeciFERR will address this critical knowledge gap and identify strategies to trigger ferroptosis. This will be accomplished by discovering and characterising novel mechanisms regulating the stability of key ferroptosis suppressors, thus providing opportunities to develop tailored strategies to target ferroptosis-sensitive entities. This project rests on our pioneering works identifying two major break systems operating against lipid peroxidation, glutathione peroxidase 4(GPX4) and ferroptosis suppressor protein 1 (FSP1). In Aim 1, using a combination of novel cellular model and target-oriented phenotypic screens, we will characterise and target pathways involved in selenocysteine uptake, mobilisation and recycling, which we found essential for the stability of selenoproteins, including GPX4. In Aim 2, we will dissect metabolic and cellular states that determine the antioxidant capacity of membranes via FSP1-dependent mechanisms using a combination of cellular systems and functional genetic screens. DeciFERR will lead to a comprehensive understanding of how ferroptosis is orchestrated and will expand the druggable inventory, providing innovative strategies that will be put to test and could ultimately pave the way for efficacious therapies against malignancies that still defy current treatments.

Keywords: ferroptosis,lipid peroxidation,solute carriers slc
KARMIC - KNITTING ARTISTIC AND RELIGIOUS MATERIALITIES WITH INDUSTRIAL CONVERSIONS (KARMIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Thailand
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-06-01
End date: 2029-04-30
Duration (months): 35.0
Total project cost (EUR): 274773.74
EU funding (EUR): 274773.74
Participants: 3
Project status: SIGNED

KARMIC - Knitting Artistic and Religious Materialities with Industrial Conversions is a research project aiming to explore and stimulate the interconnections between artistic and religious conceptions of matter and materiality and the current “green” conversions in the industrial and infrastructural sectors, especially with regard to waste mismanagement in urban contexts. The project consists of an interdisciplinary, multi-sited and comparative research, grounded along the boundaries connecting the anthropology of religions, MCS (material culture studies), public arts, materials sciences and industrial environmental politics. This crossdisciplinary frame allows to question existing experimentations leading to pragmatic co-adaptations between local communities and the industrial/infrastructural apparatuses in territories exposed to socio-ecological/climatic challenges. Aiming at applying neo-materialist analytical tools to actual experimentations in the artistic, religious and industrial sectors, the research will focus on Thai Buddhist landscapes, where creative collaborations between engaged Buddhist communities, artists and artisans, and the industrial sector in the field of waste re/up-cycling enhanced significant good practices. For this reason, the outgoing phase at Chulalongkorn University (Bangkok, Thailand) will focus on the ethnographic inquiry of activist networks and initiatives (religious and/or artistic) in the capital Bangkok -a riverine/deltaic environment, where the ecological impact of solid waste pollution hits world records- and will point to the acquisition of interdisciplinary scientific skills in environmental sciences, ethical business (focus on CSER) and materials sciences (with a focus on plastic and other recyclable materials, such as organic, glass and ceramics). The incoming phase at University Ca’ Foscari of Venice (UNIVE) will be dedicated to the refination and re-contextualization of the research concept, and to its dissemination.

Keywords: engaged buddhism,materiality,water pollution,solid waste recycling,public arts,industrial infrastructural conversions,corporate social and environmental responsibility cser,climate crisis
Rural landscape hEritage and CArbon sequeSTration (RhECAST)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 288859.2
EU funding (EUR): 288859.2
Participants: 3
Project status: SIGNED

With the ongoing climate emergency and nations’ commitments to meet net-zero carbon emissions by 2050, there is a heightened need to contrast climate change through sustainable land-use (LU) strategies. Agroforestry (AF) has existed since ancient times in European countries, and it has been recognised as one of the most beneficial rural LU systems. The RhECAST (Rural landscape hEritage and CArbon sequeSTration) project aims to develop a new interdisciplinary approach to investigate the interactions between sustainability and rural landscape heritage with particular reference to CO2 sequestration over the long term. The project will take an interdisciplinary approach that combines landscape archaeology (HLC - Historical Landscape Characterisation), computer-based modelling (MSD - Multi-Sector Dynamics) and archaeological soil geochemistry (ASG), and it will focus on one of the main European hot spots of atmospheric pollution, the Po - Venetian Plain (PVP - Italy). The main project innovation will be to develop an MSD model using HLC data to determine which would be the effect on climate change mitigation by recasting the current PVP’s industrial agriculture with historical AF. ASG will be essential to constrain the MSD model results leading to significatively more precise outcomes of past and potential future CO2 sequestration. Thus, the RhECAST project aims at modelling CO2 sequestration rate of historical AF to inform sustainable landscape management plans that will maximise climate change mitigation whilst preserving the regional cultural identity. By applying a range of innovative and interdisciplinary techniques, the project will be able to develop a model that could be potentially extended in other European regions with similar historical and environmental characteristics (e.g. Dehesa - Spain; Montado - Portugal; Plužiny - Czech Republic; Streuobst - Germany).

Keywords: agroforestry multi sector dynamics carbon sequestration rural landscape heritage archaeological soil geochemistry historic landscape characterisation
Shifting Waste Heat from Problem to Power (ZiGrid Technology)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 4147365.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

While our planet face huge challenges to meet fossil free energy supply, we waste 70% of all produced energy as heat which not only has a direct impact on the carbon footprint and costs of operation in energy intensive industries, but also on thermal pollution to the local environment. The waste heat recovery systems that make up a $55.2B market are not economically viable <90C°. This is the gap ZIGRID aims to fill with a patented unique volumetric solution that can produce electricity from heat flows as low as 90-60C°. At the heart of our technology is the 25 kW power module with a unique and robust thermodynamic cycle, insensitive to variations in the energy flow, that enables the most efficient low-grade waste heat recovery to date producing as a little as 4,3 grCO2/kWh. Power modules are connected to each other to produce electricity in cascading steps and connected to an IoT platform which allows the user to gain access to 360° business insights on electricity production. Together these features make ZIGRID ideal to produce electricity in power and processing industries. The ZIGRID-as-a-Service business model aims to de-risk the investment for the user by monetizing customer savings on (i) power consumption (ii) CO2 emission tariffs (iii) grid tariffs and (iv) avoided cooling costs while maintaining product ownership with ZIGRID thus avoiding customer decision inertia and enable the direct sales of ZIGRID power modules and reach profitable operations as early as 2028. We are requesting €2.5M in grant funding and €9M in equity from the EIC in order to test the different size configurations of the power module, its functionalities in real environments with end users from the hydrogen and paper and pulp industries, enhance our IP protection. Funding from the EIC will allow us to address the recovery of 37,000 TWh of low grade waste heat and thus the saving of 40 tons of CO2/year/~150 MWh of electricity produced, a tangible investment opportunity.

Keywords: waste heat recovery,thermodynamic cycle,low grade waste heat,sustainable electricity
Designer Biofilms: controlling cellular interactions by printing bacteria onto rationally micro-shaped surfaces. (DesiBio)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom,France,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-09-30
Duration (months): 26.0
Total project cost (EUR): 299203.58
EU funding (EUR): 299203.58
Participants: 3
Project status: SIGNED

Bacterial biofilms–conglomerates of bacteria held together by an extracellular matrix–play a major role in our lives including disrupting medical implants, industrial pipelines, or providing antibiotic tolerance to bacteria deep within biofilms by e.g., limiting antibiotic diffusion. It is imperative we understand biofilm population dynamics to improve both our health and industrial processes. However, biofilms are difficult to study because 1) they often contain multiple bacterial species or multiple genetic variants of a single species that form biofilm subpopulations, where the interactions of subpopulations are controlled by their spatial distribution within the biofilm and 2) they are often found growing on irregular surfaces with nooks and crevices, in contrast to most biofilm models on flat agar surfaces. To understand the biofilm dynamics, and thus to control it, it is crucial to analyze the impact of the surface shape and the spatial distribution of biofilm subpopulations on the biofilm formation and growth. However, we lack tractable methods to do so for several days necessary for a typical biofilm to stabilize. Here we propose a synergistic effort based on years of research by myself (surface irregularity, microfluidics expert) and the Imperial College Host (bacteria printing expert), where we aim to use microfabrication techniques, microfluidics, and droplet printing to develop a system to follow bacterial interactions in a growing biofilm where we control: a) the initial patterning of the community, b) surface irregularities on which the community grows, c) cell-surface interactions. We will work with Prof. Sujit Datta at Caltech (secondment) to follow mutant spread in biofilms in porous beds, and we will work with a Paris-based company Hummink to potentially the results of DesiBio for potential commercialization (non-academic placement).

Keywords: biofilm,microfluidics,droplet printing,bioprinting,surface shape,antibiotic resistance,antimicrobial resistance,bacteria printing,bacterial adhesion and cohesion
CAPTURING ULTRAFAST ELECTRON AND ION DYNAMICS IN BATTERIES (UltraBat)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Denmark,France,Germany,Slovakia
Call: Interface and electron monitoring for the engineering of new and emerging battery technologies (Batteries Partnership) (HORIZON-CL5-2022-D2-01, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 5407437.5
EU funding (EUR): 5407437.5
Participants: 7
Project status: SUSPENDED

Batteries are attractive candidates for lightweight, high capacity, mobile energy storage solutions. Despite decades of research, a persistent fundamental knowledge gap prevents batteries from fulfilling their potential, because the atomistic mechanisms of charge and ion transfer across interfaces in batteries remain largely unexplored by experimental techniques. When charges move, the local arrangement of atoms changes in response to the new electronic configuration. How these changes occur has a significant impact on how efficiently and how far the charges can move, yet the time and length scales are still poorly understood. Conventional experimental probes used in battery research cannot provide the needed ultrafast time and atomic length scale resolution, nor sensitivity to changes in electronic configuration around specific atomic species. Hence, it is currently challenging to unravel the dynamic rearrangement of atoms and ions which accompany electron transfer, and in turn govern the charge transfer processes. UltraBat will close this knowledge gap by pushing further the latest development of ultra-bright and ultra-fast X-ray Free Electron Laser (XFEL) scattering and spectroscopy techniques together with visible ultrafast spectroscopy to study charge transfer between different redox centres in Li-rich layered intercalation compounds and at the solid/liquid interface. Advances in NMR spectroscopy will reveal local ordering and lithium interfacial dynamics on the nanometer scale. Coupled with predictions of experimental observables from a new framework for atomic-scale simulations of the electrochemical interface and transport mechanisms, we will reveal phenomena driving diffusion of ions in complex electrode materials. This will provide the insight required for transformational approaches to control the redox reactions (e.g. electron transfer) that are common to many energy-related processes, including batteries, photovoltaics, and water-splitting systems.

Keywords: li rich ni mn co layered oxide lithium ion battery charge transfer solid liquid interface xfels ultrafast x ray techniques ultrafast optical and raman spectroscopy nmr dft simulation framework
European Universities designing the horizons of sustainability (Sustainable Horizons)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Portugal,Spain,Romania,Finland,Germany,Czechia,Angola,Mozambique,Chile,Brazil,Paraguay,Colombia,Sao Tome and Principe,Central African Republic,Nigeria,Algeria,Egypt,Sri Lanka,Bhutan,Equatorial Guinea
Call: Capacity building to strengthen networks of higher education institutions and cooperation with surrounding ecosystems (HORIZON-WIDERA-2021-ACCESS-05, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 2325576.75
EU funding (EUR): 2325576.75
Participants: 22
Project status: CLOSED

Sustainable Horizon Alliance will contribute to an inclusive society, supporting researchers/academics deeply thinking, respecting nature, practical problem-solving professionals, adapting to new challenges. We are six young HEIs, open to innovation, located in small cities within EU periphery, from South Extreme (Faro-Pt, Huelva-Es), Central (Zlìn-Cz, Ludwigshafen-De), Eastern (Timisoara-Ro) to North (Lahti-Fi) carried out activities of co-production with relevant economic regional impact. The complementary strength in sustainability scientific fields aiming at inclusive institutional transformation and providing a platform as preferential partners collaborating with surrounding ecosystems. The goals are to support the Alliance created in 2019 and in especially the Widening Countries HEIs (UAlg, BUAS UTB) to, within the network and with the best practices, define road maps to effectively implement inclusive approaches to open science policies, gender balance plans, careers management, researcher’s societal links. Our sustainability research approach will be anchors on traditional sciences (environmental, socioeconomics) but with strong interdisciplinarity innovation based on Artificial Intelligence, allowing Entrepreneurship and Employability to impact regional ecosystems. The Alliance will rely on a creative governance model with a balanced top-down and bottom-up approach with the academic/researcher clusters (Science & Technology, Health, Socio-Economics), the leadership (Rectors& Directors), to an effective institutional change that will achieve balance between careers and life, to foster a variety of joint research projects based on excellence and trustful collaboration to allow International competitiveness. Using our HEIs geographic proximity, historic, cultural and linguistic links, we aim to project the Alliance outside Europe (eg. Africa & South America) offering Distance learning PhD supporting locally at global level sustainability and a Healthy Planet.

Keywords: sustainability research,institutional transformation,synergy higher education researcher support,distance learning phd
TightRope for WorldTrans (TightRope)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Norway,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 36.0
Total project cost (EUR): 597565.0
EU funding (EUR): 597565.0
Participants: 3
Project status: SIGNED

The primary aim of the WorldTrans project is to unpack the mystery of Integrated Climate Assessment modelling and make the process of using such models more democratic and inclusive. WorldTrans proposes here to widen the team using EU's “Hop on” facility to include FCiências.ID, through its Research Center Instituto Dom Luiz at the Faculty of Sciences of the University of Lisbon, Portugal. Participation in WorldTrans is an opportunity for FC.ID scientists to engage with a society-facing transdisciplinary research agenda for the onboarding of natural sciences in social planning and policymaking, which is increasingly prioritized in Horizon calls for proposals. It will create a new line of research at FC.ID on Integrated Environmental Assessment and modeling, developing new methods to explore the societal relevance of environmental issues in educational settings, and creating opportunity for a new line of courses at the University of Lisbon. In addition, the Hop-on proposal will contribute to meeting the original WorldTrans objectives. FC.ID researchers Camara, Trigo, Soares and Russo will provide expert knowledge in modelling and analysing the impacts of single or compound climate interactions, such as the drought - fires - health nexus, in several sectoral areas, namely in the energy, finance, economy, aagriculture, and energy sectors. The strength of the feedbacks between the several sectors and the climatic constrainers will also be addressed. FC.ID researchers provide a wide range of complementary domain insights to System Tellus and will strengthen these publications by adding expertise across all IPCC WGs, but especially in WG3 (Köberle) which is underrepresented in the original WorldTrans consortium. FC.ID will bring five Early Career Researchers (ECRs) to the project: one Postdoc, two PhD students and two MSc Students. As the ECRs in WorldTrans already do, the FC.ID ECRs will work within and across Work Packages to ensure a truly interdisciplinary project.

Keywords: integrated climate assessment model,iam,feedbacks,policy,leverage,fully endogenous system dynamics