Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deciphering the Role of aberrant glycOSylation in the rEsponse to Targeted TherApies for breast cancer (ROSETTA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-07-21
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

Resistance and cancer progression remain a major obstacle to the successful treatment of cancer. In HER2+ breast cancer, the development of targeted therapies such as trastuzumab, has revolutionized the treatment for these cancer patients. However, a significant number of patients develop resistance. In this realm, my previous work focused on understanding the crosstalk of interconnected signaling pathways in HER2+ cancer cells that drive tumorigenesis and undermine the efficacy of current treatments. The research goal of this proposal is to provide a new focus to the challenge of resistance by deciphering the role of glycosylation in driving resistance to HER2-targeted therapies. Aberrant glycosylation of proteins is a hallmark in cancer and has been linked to multiple processes such as invasion, angiogenesis and modulation of the immune response. The receptor HER2, the main driver of HER2+ cancers, is heavily glycosylated and is the target of current antibody-based treatments, including trastuzumab. In this scenario, this proposal aims to (1) identify glycosylation-related genes associated with incomplete pathological response to trastuzumab to (2) dissect their role on trastuzumab binding and (3) assess their impact in the response to trastuzumab mediated by immune cells. This research plan will be accomplished combining the analysis of clinical data from tumor biopsies, the use of trastuzumab-resistant tumor-derived breast cancer cell lines and, the implementation and imaging of 3D heterotypic cultures of cancer cell line-derived spheroids and immune cells. Thus, this proposal addresses a largely unexplored layer of complexity in cancer biology – the role of glycosylation in resistance to targeted therapies – and holds the potential to identify new markers of response to therapies and open the path to new therapeutic options for the improvement of current treatments.

Keywords: breast cancer,her2,protein glycosylation,resistance,targeted therapy,3d cancer spheroids,trastuzumab,biomarker,adcc
Shifting Dynamics of Chinese Labour in a Global Perspective (Chinese Labour)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Australia
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-12-15
End date: 2018-12-14
Duration (months): 36.0
Total project cost (EUR): 250518.6
EU funding (EUR): 250518.6
Participants: 2
Project status: CLOSED

With the financial crisis stepping up the pressure on labour regimes around Europe, and with the European national economies increasingly subject to the vagaries of an uncertain Chinese growth, questions traditionally of interest only to Chinese labour specialists and rights advocates are taking a whole new dimension. Chinese labour issues have ceased to be local matters and have assumed a particular urgency, entering much of the political rhetoric of the European countries. Such diffused presence of Chinese labour in the European imaginary raises many questions and requires a thorough investigation. In particular, in the past few years, much has been written about a “rights awakening” allegedly undergoing among internal migrant workers in China. But how do Chinese workers perceive their rights? What role do Chinese state and non-state actors play in shaping this perception? And, more important, how will these shifting dynamics of Chinese labour activism affect the future of China as a “world factory”? Research that answers these questions is still scarce. The purpose of this study is threefold: a) analyse the expectations of Chinese migrant workers toward work hours and salaries, on the background of the minimum standards mandated by the current labour legislation; b) deconstruct the role played by different actors in shaping these expectation, with a particular attention to the role of the central and local state, the union, civil society organizations and foreign enterprises; c) address the implications of the rising expectations of the Chinese workers for EU investments in China and for the future of the country as a “world factory”. This research will not only give a meaningful contribution to the academic debate, but will also provide European policy-makers, companies, trade unions and labour NGOs with much needed knowledge on how to address Chinese labour issues in this new phase of the globalization process.

Keywords: china,globalization,labour,migrant workers,cambodia,activism,race to the bottom,ngos,trade unions,hegemony
PREcision medicine Drug combination testing In neuroblastoma organoids to guide Clinical Trials (PREDICT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2022-02-28
Duration (months): 60.0
Total project cost (EUR): 1406250.0
EU funding (EUR): 1406250.0
Participants: 1
Project status: CLOSED

Neuroblastoma are pediatric tumors that respond poorly to chemotherapy and have a very poor prognosis. To improve treatment options, a global development towards precision medicine is ongoing. This strongly focusses on molecular genetic target identification in tumors and subsequent assigning patients to the best trials according to their molecular profile. Still it is difficult to predict which patients will benefit from these targeted compounds. In addition, if tumors do respond to single compound targeted therapy, they almost always relapse. These tumor evolution processes could be prevented by simultaneous intervention in different activated tumor pathways. We now want to study how we can select patients that will most likely respond to a targeted compound and what combinations of targeted compounds are most effective? This can’t be tested in a clinical setting since the number of neuroblastoma patients that can be included in Phase1/2 trials is very small. Recent research shows that tumor organoids mimic human tumors and can effectively be used as xenograft in nude mice as well. These in vitro and in vivo models could be used as an alternative selection system for optimal combination treatment in a personalized approach. The overall aim is now to test if combinations of targeted compounds can cause complete remission in neuroblastoma organoid model systems to select combination treatment options for personalized clinical trials For this purpose we will generate neuroblastoma organoids that properly represents the complexity and heterogeneity of individual tumors and build a repository that represents the various subtypes of neuroblastoma tumors. We will identify synergistic compound combinations that are effective in neuroblastoma tumors that are characterized by specific molecular genetic aberrations. Thereby we will build an efficient pipeline to generate personalized models that can be used in precision medicine programs to perform compound validation.

Keywords: neuroblastoma,relapse tumors,organoids,personalized medicine
NeuroRobotics Platform Application to Traction Control for Automotive Industry (NeuroMotive)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Germany,United Kingdom
Call: FET Innovation Launchpad (H2020-FETOPEN-4-2016-2017, 2017)
Start date: 2018-07-01
End date: 2019-12-31
Duration (months): 18.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

The work proposed aims at the development of a service in Traction Control for the automotive industry, building upon innovation from the NeuroRobotics Platform (NRP, HBP-SP10). The service will use the platform’s capacity to synthesize sophisticated neural control laws. Controllers developed will be tested on a unique infrastructure, the Siemens Mobility Test Setup (SMTS), which allows physical emulation of a wide range of road conditions for any car connected. This System-in-the-Loop (SyL) setup will support machine learning processes, allowing tuning of the traction controller to a high standard of performance, and provide early control-function validation and performance assessment. The work proposed involves: A limited amount of Technical Work, to connect NRP and SMTS, and develop the required service provision tools, Market Analysis and business plan development for the envisioned service, and a heavy emphasis on Outreach and Engagement of stakeholders and potential interested end-users.

Keywords: traction control for automotive
Engineering Carbon Nanodots for (Nano)Technological and Biomedical Applications (e-DOTS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy,Spain
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 1820231.25
Participants: 2
Project status: SIGNED

e-DOTS takes advantage of nanoscale and process-intensification principles, information technology and automation/robotics to translate molecular properties to nanoparticles for use in technologically advanced challenges, ranging from high-quality bioimaging to green catalysis in water. A stringent molecular control over the synthesis and multivalent properties of “carbon nanodots”, 2-5 nm spherical nanoparticles, will allow us to shape a nanofabrication space with engineered functions. The core-shell structure of carbon nanodots, consisting of a confined core and an outer functional shell can be rationally designed by controlled chemical approaches and by a tailored choice of the proper starting materials. e-DOTS scientific objectives are planned to go beyond the state of the art, with the aim to: (i) elucidate the mechanism and the structural details in the conversion of small molecules to nanoparticles; (ii) expand the carbon nanodots preparation process window and allow its automated exploration, directed at ambitious targets; (iii) design and prepare carbon nanodots with tailored properties – in terms of size, charge, luminescence, chirality, and outer-shell functions – outperforming current technologies in green catalysis and biomedical imaging. (iv) investigate and ensure the safety profile of carbon nanodots in a safe-by-design approach. e-DOTS is a highly interdisciplinary project, based on frontier methods that the Prato group has successfully designed for the molecular modification of very diverse carbon nanostructures. Delving into fundamental aspects of carbon nanodots will allow to unfold their full potential in technological and biological applications. e-DOTS will thus offer unprecedented opportunities to the scientific community, since the specific molecular properties of the reactants can be transferred, combined and enhanced up to the nanoscale, yielding carbon nanodots tailored to function.

Keywords: carbon nanodots,carbon nanostructures,nanoparticles
Role of extreme events in Galaxy evolution (ELEMENTS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1367500.0
EU funding (EUR): 1367500.0
Participants: 1
Project status: SIGNED

The primary goal of my proposal is to provide stringent observational constraints on the cosmic origins of elements heavier than iron and on the role of extreme objects in the evolution of the Milky Way. I will do this by employing abundances of different chemical elements for hundreds of thousands of stars from my high-resolution spectroscopic survey of the disk and bulge on the 4MOST instrument. These elements trace the production in a variety of extreme astrophysical sites: hydrostatic and explosive burning, s-process in asymptotic giant branch stars and in massive stars, r-process in compact binary mergers, neutrino-driven winds of core collapse supernovae, magnetars, and collapsars. I will use the novel Non-LTE models that I pioneered and successfully applied throughout my career to provide accurate and homogeneous chemical abundances of stars. I will quantify the trends of abundance ratios and their dispersions with metallicity, age, and location that will be directly compared with the predictions of Galactic chemical evolution models. My ERC project represents the first systematic investigation of s- and r-process nucleosynthesis in a large stellar sample. I will use the comprehensive maps of chemical enrichment to constrain the multimodality of the nuclear production sites, to confine the parameter space of stellar sources capable of hosting s- and r-process, and to test the role of these extreme events in the evolution of the Galaxy.

Keywords: radiative transfer,stellar spectroscopy,chemical abundances,stellar surveys,galaxy evolution,nucleosynthesis
Health Condition Monitoring of Small Scale Tidal Generators Using Miniature Torque Sensors (TidalHealth)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Türkiye,United Kingdom
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2015-03-01
End date: 2015-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

By 2050, the size of wave and tidal energy is expected to reach an installed capacity of 100GW, which will be able to power 66 million European homes and also enable the EU to meet its target of reducing emission of green-house gases by 80-95% below 1990 levels. Tidal generators are installed in very harsh environments of the sea-bed, where saline water, unpredictable tidal flow, marine debris and suspended particle impact can cause serious damage to generator blades and gearboxes. In addition, the unpredictable changing nature of load demand causes stresses on the tidal components. The primary objective of the TidalHealth project is to commercially produce a direct torque measurement device attached to tidal generator shaft for overall condition monitoring of tidal power plants remotely. This will result in the reduction of operations and maintenance cost of the plants and thus improves the return on investment for tidal technologies.

Keywords: tidal energy,tidal generator,generator health monitoring,oandm cost of generators
The International Court of Justice and the Preservation of Peace in the 21st Century: Global Governance in Action (CaPE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

The overall goal of CaPE is to contribute new insights into the role that the International Court of Justice (ICJ) plays in the preservation of peace and global governance. In view of the geopolitical challenges of the 21st century, the project will investigate the potential that ICJ holds in relation to the settlement of international disputes and the preservation of international peace and security. CaPE’s two key hypotheses are that not only does the ICJ occupy a central position in the system of international adjudication and preservation of peace as the World Court, but it can also steer the evolution of international law by guiding the case-law of the other international courts and tribunals (ICs), and by offering a common frame of normative reference. The hypotheses will be tested by critically assessing the role and function of the ICJ in the complex environment of world society, and by locating the counter-trends of its jurisprudence. CaPE is the first project to systematically and holistically explore the peace/law distinction in the ICJ jurisprudence, and the steering function of this distinction by the operation of other ICs. The key ambition of CaPE is to contribute to the cause of peace in the current, unpredictable international environment through new insights into the role of ICJ. I am convinced that CaPE will contribute significantly to the development of an important research field, which will also impact future work of lawyers, diplomats, politicians, and NGOs within the area of preservation of peace and global governance. CaPE is based on the combination and complementarity of my academic/practical background, and that of the host, iCourts and its Director, Professor Mikael Madsen. iCourts provides the ideal academic environment for CaPE, which will provide me with training on new forms of socio-legal research, broaden my methodological approach, and improve my scholarly horizons and career perspectives significantly.

Keywords: international court of justice,preservation of peace,governance,adjudication,international courts,authority and power,european new legal realism,social constructivism,legal hermeneutics
The Age of Hostility: Understanding the Nature, Dynamics, Determinants, and Consequences of Citizens' Electoral Hostility in 27 Democracies (ELHO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-04-01
End date: 2026-09-30
Duration (months): 90.0
Total project cost (EUR): 2499838.0
EU funding (EUR): 2499838.0
Participants: 1
Project status: SIGNED

‘I hate Brexiteers, they betrayed my future’. Those words of an 18 year old on Brexit Referendum Night represent a growing and worrying phenomenon: electoral hostility. Electoral disagreements have long been seen as results of social divisions, but recent research shows that they have become a basis of antagonism in their own right in the US. Two comparative pilots I ran also found electoral hostility widespread in recent French and British elections but rare in South Africa and Australia. In the UK Brexit referendum, 51% of citizens felt anger towards opposite voters and 46% disgust. I define electoral hostility as negative feelings (frustration, anger, contempt, disgust) held towards individuals or groups as a result of their effective or perceived electoral preferences. It may occur in the campaign, post-election, and reinforce into self-perpetuating cycles of hostility as it is structured as a Mokken scale which can become ‘stages’ of hostility. While scepticism of political elites is well-studied, hostility towards fellow voters takes electoral negativity to a new level. Electoral hostility may have far reaching consequences, leading citizens to resent one another due to electoral stances and drift apart in increasingly divided societies, but also to the delegitimization of electoral outcomes and negative attitudes towards solidarity. ELHO will answer the following research question: What are the causes and consequences of electoral hostility at individual, group, and aggregate levels and how does it develop over time? The project’s innovative methods combine a 27 country multi-level panel survey, visual, physiological and field experiments, election diaries, family focus groups, a scoping survey of Election Management Bodies, and campaign and atmosphere coding. The project will also explore possible mitigation in ambitious partnership with psychiatrists, ergonomists, lawyers, EMBs and IGOs creating new Electoral Hostility Research Centre and Observatory.

Keywords: citizens,elections,identity,political behaviour,hostility,polarisation,election psychology,election ergonomics
Innovative eco-friendly crosslinker for leather and textile finishing (Green-linker)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-05-01
End date: 2017-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Crosslinkers are substances with a catalytic activity towards the polymeric chain and their main feature is the capacity to interact with separate polymeric units (by reacting with the free functional groups available along the chain) creating a net of links crossing between two chains (from here the term “cross-linker”) which leads to a 3D structure, once the film is dried (after application). This 3D structure is more solid and shows higher stability/fastness features, which result in improved resistance/fastness of the treated support (leather, fabric). Aiming at producing an innovative crosslinker able to reproduce the advantages of each rival without their faults, Italkem developed Green-Linker whose trials stated excellent features. Summarizing, Green-Linker results as the best performing in terms of highest temperature tolerance, fastest reaction time and longest pot-life, and colour fastness while its eco-friendliness level equals the best current option in the market in this regard. In addition, its competitive price is strongly supported by an improved storability, transport and logistic capacity, converting our crosslinker in the most worthwhile option. Thanks to Green-Linker, Italkem will be able to increase its sales of crosslinkers by 30% and differentiate production so to compete also in the textile sector. This will allow to reach an accumulative turnover of the present project of up to €19M and to hire 18 more people.

Keywords: crosslinker,tannery,leather,textile