Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SEismology of the MOon (SeisMo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-02-01
End date: 2018-01-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

As part of the Apollo lunar missions, four seismometers were deployed on the near-side of the Moon between 1969 and 1972, and operated continuously until 1977. There are many difficulties associated with determining lunar structure from these records. As a result, many properties of the moon, such as the thickness, density and porosity of the crust are poorly constrained. This hampers our ability to determine the structure, geochemical composition of the moon, its evolution, and ultimately the evolution of the solar system. This proposal uses modern seismic processing techniques to overcome these limitations. Using ambient noise tomography, it will provide a new, more accurate, model of the lunar crust and mantle. I will apply recent advances in the full waveform modelling of scattering at planetary scale by the host institution to the strongly scattering lunar crust. We will explore entirely new routes for planetary seismology by investigating single-station inverse problems building on recent work in rotational seismology pioneered at the host institution. The project is designed to develop a profile for myself as a planetary seismologist, and to position myself and the host institution to work on the Mars InSight mission in the future. InSight is a NASA Discovery mission, scheduled to land in September 2016, which will deploy a single seismometer on the surface of Mars. We combine the expertise of the researcher in surface wave analysis and tomographic modelling; the facilities and expertise of Ludwig Maximilian University (LMU) in ambient noise studies, full waveform modelling, modelling of seismic scatter and rotational seismology; and an interdisciplinary team of researchers with experience of the techniques and with diverse interests in geochemistry, geodynamics and planetary evolution.

Keywords: moon,ambient noise,full waveform propagation,rotational seismology,synthetics
Public Debt: Risk Management and Restructuring Optimization (DebtRisks)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Cyprus,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-06-01
End date: 2018-12-31
Duration (months): 31.0
Total project cost (EUR): 218094.3
EU funding (EUR): 218094.3
Participants: 2
Project status: CLOSED

Much we have been learning about the flawed design of eurozone form the current crisis. Non-optimality of euro as a currency zone, banking system fragmentation, weak institutional structures, insufficient political integration, lagging competitiveness and global imbalances, are all blamed for the crisis. At a country level problems are attributed, according to The World Bank and IMF, imprudent public debt management, weak macroeconomic management, and debt overhang. Our project looks into these over-arching challenges with the broad objective to: "Develop the capacity for risk management of public debt that can be used in response to crises, and to analyze policy proposals for debt restructuring and common assumption of debt in a currency union". The eurozone crisis challenges us to develop our capabilities for public debt management and advance the state-of-the-art.This is the purpose of the project. The four specific research tasks, taken together, advance the broad objective: 1. Develop an asset-and-liability management framework for risk management of public debt. 2. Operationalize the framework using multi-period stochastic programming integrated with multi-factor simulations. 3. Extend the optimization model to incorporate debt sustainability analysis and study debt restructuring of crisis countries. 4. Extend the simulation models to integrate current proposals for EU-bonds in public debt risk management. The project is devoted to complementing existing skills and broadening the fellow's knowledge base to develop models for asset-liability management optimization and EU-bond pricing, implement and calibrate them using market data, and demonstrate their efficacy in addressing policy issues for public debt management in crisis countries. The models will be tested in depth on the interesting case of Cyprus, for which we have special knowledge and data, on IMF stylized examples, and for the Italian and Argentinean debt where we also have access.

Keywords: debt crisis,eurozone,risk management,sovereign default,debt restructuring,eurobonds,liquidity premium,credit premium,multi factor simulations,optimization,stochastic programming
Chemical Biology in Zebrafish: Drug-Leads and New Targets in the Melanocyte Lineage and Melanoma (ZF-MEL-CHEMBIO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2022-02-28
Duration (months): 78.0
Total project cost (EUR): 1865345.0
EU funding (EUR): 1865345.0
Participants: 1
Project status: CLOSED

Melanoma (cancer of the melanocyte) kills over 20,000 Europeans each year and incidence continues to rise rapidly. BRAF(V600E) inhibitors have led to clinically significant improvements in outcomes for melanoma patients, yet many patients with metastatic melanoma rapidly succumb to the disease due to eventual chemoresistance, or insensitivity to the drug. Thus, it is critical to identify new therapies that can act alone, or be combined with available treatments for enhanced efficacy and/or to overcome drug resistance. An important and new therapeutic concept for melanoma is to target the melanocyte lineage. Recent evidence reveals that a melanocyte lineage specific programme maintains melanoma survival, and we have engineered the first animal model in zebrafish to demonstrate that targeting the master melanocyte lineage transcription factor MITF leads to rapid melanoma regression. Thus, understanding and targeting the melanocyte lineage is directly relevant to melanoma, and reveals therapeutically targetable processes. Our vision is to use live-imaging of the melanocyte lineage as the basis for phenotypic chemical screens in zebrafish to find drugs/leads and identify targetable processes that might elucidate pathways for cancer therapy. Screening for targets of the melanocyte lineage is highly relevant to melanoma because melanocytes are the melanoma cell of origin, and genes that specify the melanocyte stem cells and the lineage during embryogenesis are the same genes that play fundamental roles in cancer. We will use innovative chemical-biology to capture and validate targets in vivo, and perform chemo-preventative and -therapeutic trials in zebrafish melanoma models using known and novel drug-delivery methods. Ultimately, we aim to translate our most promising drug/leads and targets into the mammalian system, to establish the basis for patent applications and clinical trials.

Keywords: melanocyte,melanoma,cancer stem cells,drug lead,drug development,target id,small molecules,biochemistry,imaging,tumour regression,genetic engineering,crispr,zebrafish,model systems
Between saints and celebrities. The devotion and promotion of stigmatics in Europe, c.1800-1950 (STIGMATICS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2019-03-31
Duration (months): 48.0
Total project cost (EUR): 884725.0
EU funding (EUR): 884725.0
Participants: 1
Project status: CLOSED

By far most of the historical studies on the 'golden age' of the stigmatics have focused on medical debates and religious treatises. This project wants to move beyond the traditional historiographical emphasis in at least three ways. First of all, it will focus on the popular perception of stigmatics in the nineteenth and early twentieth century and examine how they became symbolic figures of political and religious causes. Secondly, we will study the interaction of the 'victim souls' with their communities and examine how they were turned into 'living saints' through religious practices and discourse, and how some of them were eventually even beatified and canonized. Thirdly, we will address them as carefully constructed religious commodities (celebrities) and rebalance the research on the selling of religion that has adopted a top-down perspective and focused primarily on the popularization of authorized cults rather than on the impact of the commercialization from the bottom-up. Combining these three aspects in studying the stigmatics, the project will enhance our understanding of the role of (new) media and consumption practices in religious change and the construction of religious identities. As each of these emphases calls for a study that takes into account chronological and geographical differences, we will adopt a comparative approach and examine five of the countries where most of the (hundreds of) stigmatics have been attested (Italy, Spain, France, Germany and Belgium). This will allow us to trace larger trends as changes in the type of stigmatic (e.g. bedridden silent 'sign' or a socially engaged charismatic leader) and moments and locations of increased attention (e.g. political crises). However, since this was the era of an internationalized Catholicism the countries will not be studied in isolation and special attention will be given to transnational attraction (e.g. pilgrims) and the related differences in promotion and perception.
Statistical analyses and composite indicators in research and innovation (INNOVA_MEASURE 2)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Coordination and support actions
Countries involved: Belgium
Call: Europe (H2020-Adhoc-2014-20, 2015)
Start date: 2015-11-01
End date: 2017-03-31
Duration (months): 17.0
Total project cost (EUR): 400000.0
EU funding (EUR): 400000.0
Participants: 1
Project status: CLOSED

The study has FIVE foci of interest: 1) to better understand the sectoral and cross-country differences in fast-growing enterprises in Europe 2) To investigate the role of research mobility in steering research excellence, by analyzing the impact of researchers’ inflows, outflows, and “turbulence” (inflows + outflows) on the citation impact or research excellence of universities and other research organizations 3) to explore the location determinants of foreign direct investments in R&D at the regional level in EU-28 countries 4) to provide support in the improvement and refinement of existing indicators to measure research excellence and innovation output 5) to investigate the impact of EU research funding initiatives on the production of excellent research.

Keywords: indicators,composite indicators,innovation,econometrics,fast growing firms,research excellence,mobility,eu funding
Molecular Analytical Robotics Assays (MARA)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Poland,Denmark,United Kingdom,United Kingdom
Call: FET-Open research projects (H2020-FETOPEN-2014-2015-RIA, 2015)
Start date: 2015-12-01
End date: 2020-08-31
Duration (months): 57.0
Total project cost (EUR): 3996477.5
EU funding (EUR): 3996477.5
Participants: 6
Project status: CLOSED

Diagnostic tests are essential to provide a targeted treatment of infectious diseases and to contain the further spread of multidrug resistant pathogens. Current methods are based either on cultivation or on PCR and have significant limitations concerning the clinical requirements to characterise pathogens including their resistance mechanisms within 3 hours. In MARA, we will develop and combine three radically novel technologies that will lead to substantial breakthroughs in science, medicine and industry and, as proof-of principle, use them to create a DNA-based molecular toolkit characterising pathogens. First, the detection of pathogen-associated antigens will be performed by Autonomous Detection Nucleic Acids (AUDENA) that are independent of any laboratory instruments and sophisticated processing. The realisation of the AUDENA concept will lead to an autonomous, stable, simple and very economic novel sensor class applicable for any water-soluble substances. The second revolutionary technology in MARA employs a novel approach in protein mimicry and creation of artificial enzymes, which represents a breakthrough in several disciplines, such as biotechnology, biomedical manufacturing and the energy sector. The third breakthrough in this project represents the development of a Molecular Robot (MORO) that can specifically identify target cells and destroy them. In MARA, the MORO will be used for the lysis of bacterial cells to release intracellular antibiotic resistance associated antigens, but the long-term vision anticipates an application as antibiotic replacement for infectious diseases and a therapeutic agent for cancer treatment, which would represent one of the most important breakthroughs in medicine in the recent years. To meet the highly ambitious objectives pointed out in this proposal, MARA is driven by a complementary, multidisciplinary team of leading experts, with a young, high-profile scientist in the lead.

Keywords: infectious diseases,diagnostics,dna origami,aptamers,artificial enzymes,molecular machines
Enertechnos Capacitive Transfer System for efficient electricity transmission and distribution. (CTS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-25
End date: 2019-03-24
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Our Capacitive Transfer System (CTS) is a new cable/line geometry that is inherently more efficient than conventional cable design. Instead of a solid ohmic conductor, the cable core is composed of coupled capacitors that transfer energy from the source to the load. Despite this, its other critical dimensions are identical to conventional lines and can be manufactured on conventional machinery with minimal adaptation. The ability of CTS to transfer power is based on its capacitance, which increases with the length of the cable, meaning longer sections of cable can transfer more power, without voltage drop, in direct contrast to conventional cables. Delivering up to 40% more active power and with voltage losses of only 2.57% (6x better than conventional cable). Voltage drop decreases with increased cable length and delivered power increases, these are both in direct contrast to conventional cables. CTS will allow significant capex and operational savings to the owners/operators of electrical grids. The main customers of Enertechnos will be the manufacturers of standard Transmission and Distribution (T&D) cables and lines. The users will be Transmission and Distribution Network Operators. CTS delivers more, and better quality power which will have a long-term ongoing beneficial impact on system losses. We will sell licences to the manufacturers of T&D cables and charge 5% royalty on each km of cable they sell. Go-to-market segment will be the Distribution Network Operators. The global T&D infrastructure market was estimated to be ~$282 billion in 2016. The cable and line portion of this market was estimated to be worth $63 billion in 2017 rising to $90 billion in 2020. The senior management has over 100 years’ experience in starting, growing and managing businesses, holding senior executive and consultancy positions in the energy, IT and hi-tech industries. SME Instrument funding will provide crucial non-diluting funding to help us hold our first in-field pilot trial

Keywords: electrical network,national grids,cable infrastructure,power transmission,reduced losses
An edible and biodegradable, ZERO SUGAR straw to accompany cold drinks or cocktails, preventing plastic residues. (Sugar Free Sorbos)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2019-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

SORBO MJV SL has developed a unique biodegradable, edible and flavored straw to substitute plastic straws, a residue which generates an important environmental and health impacts in life of population. The original sugar sustainable straws do not modify the taste or color of the drink, as the constitutive material was developed from a genuine SORBOS formula with the right rigidity, durability and stability. However, the market is now demanding repeatedly a sugar-free option, representing a huge challenge as the formulation and the equipment required must be radically modified. The plastic straw is useful only for a few minutes and often end up escaping into waterways. The production and distribution of plastic has a huge carbon footprint, which is exacerbated because so many plastic products are designed to be disposable and are destined for the landfill after just one use. However, tons of them reach the oceans where marine birds and wildlife become entangled, or choke on our plastic waste, or mistake it for food. The edible straw from SORBOS could help reduce the amount of plastic in oceans and save millions of fish and other marine life preventing the introduction of toxins in the human food chain. It should be considered also post-drink snack and promptly a functional food when adding vitamins and nutrients.Sugar-free SORBOS will be the first healthy, edible and aromatized straw in the market, 100% biodegradable and respectful with the environment with personalization in terms of aroma, flavour, colour and size and using and innovative complex production process first in class.

Keywords: sugar free straw,plastic ban,edible straw,biodegradable,flavoured,coctails,soft drinks,beverage,sea protection,residues elimination,healthy food,environmental protection,ocean pollution
Next generation analysis of the oldest ice core layers (GOLD-ICE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-15
End date: 2021-01-14
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

In order to prepare for future climate changes we need to understand the fundamental dynamics of our climate system. To this end it is crucial to understand the role of greenhouse gases in the past shift some 1.2 million years ago from 40k to 100k year periodicities dominating our climate system. Only studying the deepest, and oldest ice layers of Antarctica can provide us with an answer. However, the deepest layers are inevitably highly thinned, thus calling for ice core analysis at unprecedented detail. Succeeding where conventional cm-resolution melting techniques fail, Laser-Ablation Inductively-Coupled Plasma Mass Spectrometry (LA-ICP-MS) has recently started to emerge for glaciochemical analysis at sub-millimeter depth resolution. The project proposed here takes a novel approach to establish LA-ICP-MS for ice core analysis at the Università Ca' Foscari Venezia. Unique synergy exists for this purpose, based on the leading expertise in trace element ice core analysis of Professor Carlo Barbante at the Institute for the Dynamics of Environmental Processes and the state-of-the-art know-how in applying LA-ICP-MS to ice cores recently obtained by the proposer. LA-ICP-MS is an essentially non-destructive technique, and offers the opportunity to re-visit existing archive pieces from previous ice core drillings. In so doing, the project targets a two-fold application to investigate previously untapped paleoclimatic signals stored in the highly thinned deep layers of Antarctic ice cores. At the same time, a comprehensive view on potential limitations arising on this fine is integrated in its unique approach to avoid misinterpretation of the novel LA-ICP-MS signals. By this means, the project will fully unfold the potential of LA-ICP-MS for ice core analysis, opening new avenues of research in Europe at the forefront of future prestigious ice coring projects.