Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hegel's Philosophy of Biology (HoBi)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 2
Project status: CLOSED

The project addresses Hegel’s philosophical stance concerning the nature of organismic life, which in contemporary terms might be defined as his philosophy of biology. It asks how Hegel assesses the ontological status of living organisms, the purposive features of living systems, and the relation between life and cognition. It further asks whether Hegel’s philosophy of biology can be interpreted as a theory of biological autonomy. While extensive literature has been devoted to Kant’s philosophy of biology, Hegel's work on this topic remains largely unexplored. This is due to a long-lasting preconception against his philosophy of nature, which originated in the nineteenth century and still reigns today. The challenge of the project is to remove this preconception. The term “biological autonomy” was coined by biologists Humberto Maturana and Francisco Varela to define the ability of a living system to produce and maintain itself. My working hypothesis is that the framework of biological autonomy provides the most effective template for re-reading Hegel today and that Hegel’s theory of biological individuality is extremely useful for those who aim to lay the philosophical groundwork for the articulation of a biologically compelling theoretical alternative to the mechanistic conception of life.

Keywords: hegel,philosophy of nature,philosophy of biology,dialectical biology,biological autonomy,autopoiesis
The incident management tool to use when everything goes wrong (PulSAR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Iceland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Despite the growing numbers of crises (both natural and human-caused), most entities do not operate with proper management systems for emergencies, but instead use conventional project management software that works only in safe conditions. Thus, whenever a disaster strikes (floods, earthquakes, etc.), there is a life-threatening incidence or an emergency situation (terrorist attack, fire etc.), regular management tools break down and cause further chaos. Moreover, the different players usually involved in incident management (e.g. police, firemen, emergency services, etc.) each have their own management procedures, which do not enable effective and timely communication and coordination. Our company, SAReye ehf was founded in 2013 to develop solutions for these issues, and so we present PulSAR, the first user-friendly and cost effective incident management software, which combines disaster management with Search and Rescue. In this way, it provides immediate network and continuous status notification (if necessary on a national level for achieving the highest cooperation) as well as tailored pre-plans to handle different types of incidents. Experts have defined PulSAR as “an outstanding Incident Management System that fits perfectly with needs in small regional incidents as well as national calamities.” (J. S. Hjartarson, CEO Icelandic Search and Rescue) and is gathering huge interest from all kind of stakeholders, from first responders, and public safety communities, to governmental level: we recently received the Annual Honor IT Achievement Award 2017 for "an outstanding contribution in the field of information technology, creating value and enriching the Icelandic community with utilisation of IT" from the president of Iceland herself. Our next aim upon the great results that we have is thus to increase PulSAR’s range of application even more, implementing new modules with tailored solutions for specific incidents while strengthening our presence worldwide.

Keywords: incident manager,search and rescue,emergency,cooperation,up to date communications,preparedness plans
Research and Training in Early Life Nutrition to Prevent Disease (GROWTH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,France,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-06-01
End date: 2024-04-30
Duration (months): 59.0
Total project cost (EUR): 2133077.52
EU funding (EUR): 2133077.52
Participants: 8
Project status: SIGNED

The interplay between nutrition, gut microbiota, and its large numberof metabolic and immune mediators plays an essential role in the development of gut immune homeostasis in early life. This interaction needs to be better understood because a disturbed immune function in the neonatal period is harmful for neonatal survival and enhances the risk of chronic inflammatory disease later in life. In particular, preterm infants have an immature gut and an associated intestinal state of dysbiosis, which limits the efficacy of nutritional interventions to 1) support early life nutrition, 2) prevent sepsis and conditions such as necrotizing enterocolitis and intestinal failure, and 3) reduce the risk of chronic inflammatory diseases mediated by the gut. A major barrier to elucidating the critical nutritional-host-microbiome interactions and reducing neonatal mortality is the lack of expertise in this rapidly emerging area of metabolomics. We therefore proposes a multidisciplinary approach making use of a large-scale pre-existing clinical cohort of neonates, and state of the art analytical and bio-informatics tools. GROWTH is an Innovative Training Network focused on European Industrial Doctorates that aims to train young business-oriented researchers in developing pathological insights, biomarker diagnostics and personalized nutritional interventions for intestinal failure in neonates and preterm infants. As a multidisciplinary consortium that will involve the participation of 7 non-academic and 5 academic partners in the life sciences field and will attempt shortening the path from basic research to clinical applications.

Keywords: early life nutrition,intestinal failure,sepsis,necrotizing enterocolitis
EEN Innovation Support Services for SMEs in North West Italy (ALPS INN3)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Italy,Italy,Italy
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 126335.0
EU funding (EUR): 126335.0
Participants: 8
Project status: CLOSED

The project, whose geographical coverage will be North-West Italy (3 regions : Piemonte Liguria and Valle d’Aosta) aims at providing and upgrading a specific framework service for supporting SMEs in the innovation management capacity . The service will be directed to SMEs with international growth potential via product, process service and or business model innovation- with gaps regarding innovation management. In particular, the action will focus on the following specific objectives: 1. Fine tuning of a Key Account Management based customised service provision directed to: a. SMEs /Scale ups international growth, including participation to European programs b. SMEs Innovation capacity enhancement and innovation projects implementation, job creation and new market access c. SMEs Innovation results exploitation 4. Integration of the service within local business innovation support delivered, EEN specific service official embedding within the regional innovation ecosystem 5. Advisory skill enhancement: ALPS EEN personnel, assisting the experts in this Action, will increase expertise and competences, providing high level advisory on innovation management 6. Upgrading a EU shared support methodology for EEN staff, which could be adopted for profitably supporting other local SMEs 7. Contribution to the enhancement of a visible and well identified Coach/EEN experts community at EU level 8. Updating the operational internal manual/chart for a harmonized service within the EEN ALPS Consortium and contribution to definition of a common EEN operational manual

Keywords: innovation management,sme instrument,fet open,scale up,growth,innovation results explotation
Feasibility study for Bioapplications – BioBalanced Farm probiotic (BioBalanced)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Lithuania
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-07-01
End date: 2018-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

A rapid emergence of resistant bacteria occurs worldwide, endangering the efficacy of antibiotics, which have transformed medicine and saved millions of lives. The antibiotic resistance crisis has been attributed to the overuse and misuse of these medications. 700 000 patients die annually as a result of infections caused by antibiotic resistant bacteria. Due to a growing demand to substitute medicine and hazardous chemical usage in agriculture, Bioapplications developed the BioBalanced Farm Probiotic – a unique probiotics blend, which is misted in the facility, naturally excludes pathogenic bacteria and prevent mutation and development of resistant bacteria. The Solution also strengthens immune system, improves the welfare and increases the mass of the livestock, reduces bad odours, and generally improves a quality of meat. Consequently, farmers are able to fight. According to Eurostat, there were 331.16 million Livestock Units (LSUs) in 2017 – 44.47% were pigs, 26.9% were cows, 26.3% were sheep’s and 3.9% were goats. Since pigs are the most prevalent in Europe and antibiotics are heavily overused in pig farms, the commercialisation of the solution will be firstly focused on pig farms. With a total of 147.24 M pigs in EU-E8, the total available market size for BioBalanced Farm probiotic is 88.34 M square meters. Bioapplications will enter the market by targeting large pig farms in home market Denmark, followed by Spain, Germany, the Netherlands and Belgium. After a successful commercialisation, Bioapplications plans to scale-up by expanding into other EU regions and providing the service to poultry and cows farms. Commercialisation strategy includes three steps: preparation for market entry (home markets), market replication (large pig farms in target countries) and scaling-up (large pigs/poultry/cow farms in other EU countries). The Solution developed by Bioapplications is currently at TRL 6: prototype that is validated in industrially relevant environment stag

Keywords: probiotics,antibiotics,livestock,immune system
Low NOx / low sOot injection system design for sPinning combuStion technology (LOOPS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France,France
Call: Low NOx / Low soot injection system design for spinning combustion technology (H2020-CS2-CFP10-2019-01, 2019)
Start date: 2020-05-04
End date: 2023-08-03
Duration (months): 39.0
Total project cost (EUR): 591280.0
EU funding (EUR): 591280.0
Participants: 3
Project status: SIGNED

Safran Helicopter Engines has recently developed and patented a new spinning combustion technology (SCT). This innovative technology improves ignition and blow-off capabilities and enables combustor weight reduction, without compromising turbine nor combustor lifetime. To further promote this highly promising technology, the next step is to assess SCT performances in terms of NOx and soot emissions. Indeed, new aeronautical technologies entering the market today must comply with international regulations and answer the public environmental concern about global warming and human health. To assist Safran in this development phase, the LOOPS project aims to design, manufacture, test and model an advanced low-NOx and low soot/particles injection system for SCT. The technology is based on the multi-point injection concept, which has already demonstrated very good low-NOx capabilities. The challenge is to guarantee low soot emission as well, which may be detrimental to other pollutant reduction. Two injectors will be designed and evaluated in a systematic way for both NOx and soot emission using combined measurements and numerical simulation. On the experimental side, the most advanced experimental diagnostics will be used, providing in particular and for the first time a complete and detailed characterization of the soot particles with their concentration and size distribution. On the numerical side, a significant contribution of LOOPS will be the assessment and application of accurate models for NOx and soot production in real helicopter engines. The confrontation of measurements and simulation results will allow to evaluate the accuracy of the numerical approach and to better understand the underlying mechanisms of pollutant emissions. In addition to a new low-emission injector systems for SCT, outputs of the project will be guiding rules, as well as an engineering numerical tool for low-emission SCT, allowing to find the best compromise between competing phenomena.

Keywords: combustion,injection,particulate,emission,soot,simulation
Energy-efficient SCalable Algorithms for weather Prediction at Exascale (ESCAPE)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: High Performance Computing
Action type: Research and Innovation actions
Countries involved: Ireland,Germany,Switzerland,Switzerland,Belgium,Poland,France,France,United Kingdom,Denmark,United Kingdom,United Kingdom
Call: HPC Core Technologies, Programming Environments and Algorithms for Extreme Parallelism and Extreme Data Applications (H2020-FETHPC-2014, 2014)
Start date: 2015-10-01
End date: 2018-09-30
Duration (months): 36.0
Total project cost (EUR): 3977952.5
EU funding (EUR): 3977952.5
Participants: 12
Project status: CLOSED

ESCAPE will develop world-class, extreme-scale computing capabilities for European operational numerical weather prediction (NWP) and future climate models. The biggest challenge for state-of-the-art NWP arises from the need to simulate complex physical phenomena within tight production schedules. Existing extreme-scale application software of weather and climate services is ill-equipped to adapt to the rapidly evolving hardware. This is exacerbated by other drivers for hardware development, with processor arrangements not necessarily optimal for weather and climate simulations. ESCAPE will redress this imbalance through innovation actions that fundamentally reform Earth-system modelling. ESCAPE addresses the ETP4HPC SRA 'Energy and resiliency' priority topic, developing a holistic understanding of energy-efficiency for extreme-scale applications using heterogeneous architectures, accelerators and special compute units. The three key reasons why this proposal will provide the necessary means to take a huge step forward in weather and climate modelling as well as interdisciplinary research on energy-efficient high-performance computing are: 1) Defining and encapsulating the fundamental algorithmic building blocks ("Weather & Climate Dwarfs") underlying weather and climate services. This is the pre-requisite for any subsequent co-design, optimization, and adaptation efforts. 2) Combining ground-breaking frontier research on algorithm development for use in extreme-scale, high-performance computing applications, minimizing time- and cost-to-solution. 3) Synthesizing the complementary skills of all project partners. This includes ECMWF, the world leader in global NWP together with leading European regional forecasting consortia, teaming up with excellent university research and experienced high-performance computing centres, two world-leading hardware companies, and one European start-up SME, providing entirely new knowledge and technology to the field.

Keywords: weather prediction,berkeley dwarfs,accelerators,numerical methods,benchmarking
Coherent manipulation of cold trapped ions in Rydberg states (RydIons)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The project aims at developing a full coherent control of cold, trapped ions excited to Rydberg states. The experiment will be implemented using laser-cooled atomic ions at microkelvin temperatures in a microfabricated radiofrequency ion trap. The superb control over internal and external degrees of freedom in cold ions will be combined with the high flexibility offered by the Rydberg interaction that enables accurately tuning the strength as well as the angular dependence of the interaction. Building on this control, the researcher will investigate fundamental physics in long-range interactions between such highly controllable quantum systems. New techniques will be developed to generate quantum states that are independent from the trapping field using specific dressed states in a microwave field as well as a fast switching electric field. This will enable the excitation to high-laying Rydberg states, and thus the observation of new quantum effects, i.e., the Rydberg blockade effect in cold ions. Furthermore, coherent excitation of these quantum systems will be achieved based on a two-photon excitation scheme, while the focus will be on experiment with multi ions in linear as well as two-dimensional arrays. The project will establish a novel approach for understanding the physics of strongly correlated many-body systems. Therefore, the proposed research will pave the way for the implementation of quantum simulators based on fast switchable Rydberg ions as well as for the exploration of the underlying mechanism of symmetry-breaking defect formations. This quantum technology has the potential application for simulating the transport of vibrational excitations along protein chains.

Keywords: trapped ions,laser cooling,rydberg interaction,coherent excitation
Identification and characterization of sites of lipid droplet biogenesis in the ER (LD_Biogenesis)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-03-01
End date: 2020-03-14
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

Lipid droplets (LDs) are evolutionarily conserved dynamic organelles dedicated to storage of fat. Relatively little is known about the molecular processes that regulate nascent LD formation at specific sites in the endoplasmic reticulum (ER). Understanding LD biogenesis and degradation is crucial for deciphering the pathophysiology of LD storage disorders, like obesity, diabetes type-2, atherosclerosis, and lipodystrophy. The main objective of this project is to precisely map and characterize LD biogenesis sites in the ER using the model eukaryote, S. cerevisiae. One reason so little is known about the earliest stages of LD biogenesis is that until recently we have not had tools to visualize and characterize these sites. However, I have generated a yeast strain in which it is possible to use electron microscopy to image the earliest stages of LD biogenesis. In a recently published study I used this strain to characterize early stages of LD biogenesis and I propose to use this strain to investigate the role of a number of proteins in LD biogenesis by using mutants lacking these proteins. In addition, I have developed the first fluorescent protein marker of sites of nascent LD biogenesis. This new protein will allow me to use fluorescent microscopy to visualize LD biogenesis in live cells and in mutants lacking proteins known to be involved in LD biogenesis. I will also use this protein as a molecular tool to identify proteins and lipids that are enriched at LD biogenesis sites in the ER by performing immuno-purification and mass-spec analyses. The proposed studies will reveal and identify proteins and lipids necessary for the earliest stages of LD biogenesis and will make possible future mechanistic studies of LD biogenesis. My participation in “LD_biogenesis” will broaden my scientific expertise and hone my competences in becoming a successful project investigator.

Keywords: lipid droplets,yeast,lipid droplet biogenesis,triglyceride synthase