Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cancer cell plasticity on targeted therapy (CANPLAST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: SIGNED

Novel cancer molecular-targeted therapies allow to significantly prolong the survival of cancer patients. However, the inevitable acquisition of resistance mechanisms limits the clinical benefit of these treatments. To fully understand how resistance develops, it is crucial to better integrate tumor heterogeneity, cancer cell plasticity and microenvironment changes by applying cutting-edge single cell technologies directly on sequentially sampled biopsies from cancer patients. Additionally, to achieve deeper and longer-lasting clinical responses for cancer patients, we will need to target the rare drug-tolerant persister cancer cells. Samples collected before, during and after treatment will be used to fully describe the characteristics of the cells that are the source of genetic resistant variants that ultimately give rise to tumor relapses. By combining the establishment of patient-derived models, drug-screening of epigenetic inhibitors, transcriptomic and epigenetic characterization of persister cells we will aim to highlight their vulnerabilities. Finally, identify the driver mechanisms of genomic evolution by elucidating the link between oncogenic kinases and DNA repair pathways activity will be our innovative strategy to exploit putative susceptibilities to impeach the survival of resistant cells. The use of DNA repair substrate combined with CRISPR gene knockout will aim at confirming the value of targeting DNA repair pathways to profoundly transform the outcome of patients with metastatic cancer. Overall, by applying new technological breakthrough at the single cell level on patient biopsies, digging into the intrinsic nature of persister cells and taking advantages of DNA repair defects we will identify innovative treatment strategies to avoid the emergence of resistance in patients.

Keywords: persister cancer cells,targeted therapy,resistance
Learning network for Advanced Behavioural Data Analysis (LABDA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,Denmark,Norway,United Kingdom,Belgium,India,France
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-02-01
End date: 2027-01-31
Duration (months): 48.0
Total project cost (EUR): 3010374.51
EU funding (EUR): 2881036.8
Participants: 20
Project status: SIGNED

BACKGROUND Recently, there has been a paradigm shift from the isolated focus on the health impact of single behaviours (physical activity, sedentary behaviour, sleep) to the combined health effects of 24/7 movement behaviours. Technological advancements have led to wearable sensors providing rich time-series. Such large-scale data require novel analysis methods to provide detailed insight into the links between multidimensional 24/7 movement behaviour and health, potential relevant subgroups, and relevant behavioural characteristics to target in interventions. CONSORTIUM In LABDA, leading researchers in advanced movement behaviour data analysis at the intersection of data science, method development, epidemiology, public health, and wearable technology are brought together to address this challenge. AIM: To train a new generation of creative and innovative public health researchers with strong analytical and data science skills, and a deep understanding of all aspects of wearable sensor data analysis, that are able to develop innovative analysis methods and apply these in various contexts. WORK PLAN Via training-through-research, 13 doctoral fellows establish novel methods for advanced 24/7 movement behaviour data analysis and assess the added value of linking multimodal data. They develop a joint taxonomy to enable interoperability and data harmonisation. Results are combined in an open source LABDA toolbox of advanced analysis methods, including a decision tree to guide researchers and other users to the optimal method for their (research) question. IMPACT The open source toolbox of advanced analysis methods will lead to optimised, tailored public health recommendations and improved personal wearable feedback concerning 24/7 movement behaviour. After the project, LABDA fellows will be in an excellent position to pursue careers in academia (epidemiology, data science), commercial business (wearable technology, consultancy), or government (public health policy).

Keywords: movement behaviour method development wearables accelerometry physical activity sedentary behaviour sleep public health guidelines
ADVANCED VALIDATION AND TESTING ENVIRONMENT FOR ENHANCING THE EU HW AND SW VULNERABILITIES ASSESSMENT AND SECURITY BASED ON INNOVATIVE AI SERVICES (ATHENA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Innovation actions
Countries involved: Spain,Greece,Norway,Italy,Poland
Call: Approaches and tools for security in software and hardware development and assessment (HORIZON-CL3-2024-CS-01, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 6301635.0
EU funding (EUR): 5190153.75
Participants: 12
Project status: SIGNED

ATHENA will bring a flexible and scalable Cyber-security solution for being used by SW&HW manufacturers, including microenterprises, small and medium-sized enterprises (SMEs), organizations CISOs and cyber-security personnel. This solution will allow the above-mentioned stakeholders to test, validate and ensuring their SW&HW products compliance with the new EU mandatory security requirements (CRA) and its readiness for certification following the schemes proposed by the EU Cyber-security Act Certification Framework (CACF). In addition, this solution will include a security engineering dedicated tool to guarantee the reliability of new SW&HW from the early development phases and its compliance with both, the EU mandatory essential requirements for the security of products with digital elements stated in the new EU harmonised legislation (e.g. Cyber Resilient Act (CRA) , NIS2 , Data Act ) and the stakeholders own security needs. Furthermore, several innovative security services based on Artificial Intelligence (AI) along with a cutting-edge automatic vulnerabilities detection and assessment toolset will be developed and integrated in the ATHENA solution for ensuring the continuous SW&HW products security assessment and protection against complex cyber threats.

Keywords: ai based security services,vulnerabilities assessment,security engineering
Fibroblasts-microbiome crosstalk in tissue regeneration and fibrosis: unraveling novel therapeutic targets through single nucleus RNA-seq, multi-omics and spatial analysis (REGENER-OMIX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2029-08-31
Duration (months): 36.0
Total project cost (EUR): 401232.0
EU funding (EUR): 401232.0
Participants: 2
Project status: SIGNED

Upon injury or disease, most human organs yield fibrotic tissue resulting in permanent scars and the failure of tissue function, compromising the health span and lifespan of affected individuals. Organ fibrosis is influenced by a myriad of factors, including fibroblast heterogeneity, the activated signal transduction pathways and environmental cues. Fibroblasts hold a central role in fibrosis, yet a nuanced understanding of their heterogeneity driving regenerative versus fibrotic healing remains elusive. Recently, it was shown that the microbiome regulates inflammation and extracellular matrix remodeling. However, the microbiota function in tissue regeneration and fibrosis is poorly characterized. Integrating microbiome insights into anti-fibrotic approaches is an uncharted territory. REGENER-OMIX aims at investigating: 1. fibroblast heterogeneity and, specifically, the microbial components-recognizing fibroblasts, and the wound microbiome in the regenerative oral mucosa and pro-fibrotic skin; 2. the fibroblasts-microbiome crosstalk through spatial analysis; 3. the role of the microbiome in the healing outcome toward regeneration or fibrosis. To address these objectives, I will leverage advanced transgenic models, cutting-edge single nucleus RNA-seq, multi-omics and spatial biology techniques through a novel and interdisciplinary approach. The project (36 months) will unravel the interactions between fibroblasts and microbiome, and their functional role in regeneration and fibrosis. This study will offer new avenues to manipulate the healing process and antagonize fibrosis-associated pathologies. I will combine the strengths of a USA-based research group, world-leading expert in wound healing and fibrosis, with the expertise of a world-renowned Europe-based laboratory, who pioneered host-microbiome research. This sets the stage for a unique environment for my postdoctoral training, knowledge exchange and new research lines to be explored.

Keywords: fibrosis,regeneration,multi omics,fibroblasts,skin,microbiome,oral mucosa,spatial biology,tissue repair
Hub Molecules of Metabolism and Signalling – Key regulators of Life (HubMOL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway,Spain,Netherlands,Germany,Denmark,Italy,Switzerland,Austria
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 4539624.59
EU funding (EUR): 4181039.9
Participants: 21
Project status: SIGNED

Metabolic disorders are a major burden on the European population and health care systems. Moreover, metabolic perturbations contribute substantially to other pathologies such as neurodegenerative disorders and cancer. The causes of metabolic dysregulation are manifold and lead to pathological shifts, often in response to imbalanced nutrition. Likewise, changes in metabolism affect signalling mechanisms and gene regulation, aggravating the pathology. The mechanisms of this interdependence between metabolism and signalling are still not well understood. HubMOL will fill this knowledge gap and open new horizons by exploring the functional duality of a set of small molecules that are involved in all cellular functions - the Hub Molecules Of Life (HubMOLs) including ATP, SAM (S-adenosylmethionine) and the vitamin-derived cofactors, NAD, FAD, and CoA. They are key components of both metabolism and signalling networks and are interconnected, for example, through their participation in posttranslational protein modifications (PTMs). The complexity of this emerging area requires interdisciplinary scientists equipped with comprehensive competences covering experimental, computational and systems biology as well as clinical medicine. Therefore, the main HubMOL goal is to provide world-class training in these areas to 16 DCs enabling them to establish fundamentally new insights into cofactor biology and lay the ground for patient-tailored vitamin supplementation concepts. The strategic exposure of the 16 young researchers to leading European academic institutions, companies and clinical environments combined with systematic training in entrepreneurship and transferable skills will strongly improve their employability for positions in both private and public sectors. HubMOL will impact patients and society by developing therapies for metabolic and regulatory imbalances based on hub molecule biology.

Keywords: coenzymes,protein modification,acetylation,methylation,nad,coa,nutrition,vitamin supplementation,metabolic flux,kinetic modelling,sirtuins
Novel fibre value chains and ecosystem services from sustainable feedstocks (FIBSUN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Research and Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Finland,Netherlands,Sweden,Germany,Portugal,France,Italy,Greece,United Kingdom
Call: Sustainable fibres biorefineries feedstock (HORIZON-JU-CBE-2022, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 4521790.0
EU funding (EUR): 4354416.52
Participants: 18
Project status: SIGNED

In order to stimulate the rural bioeconomy and industrial competitiveness, achieve climate mitigation and biodiversity targets, and increase the resilience of production systems, the European Union needs forerunners, both in primary production and industry. Despite the widely recognised and urgent need to substitute fossil raw materials with renewables, under-developed biomass processing methods and business models, and poor understanding of the multiple benefits of well-planned, novel applications currently restrict the implementation of sustainable value chains with balanced environmental, economic and social outcomes. Every step in the novel bio-based fibre value chains targeted by FIBSUN need to be optimised, from cultivation practices, industrial processes, and business models, through to understanding the needs of consumers. The use of novel industrial feedstocks must not lead to undesirable land-use changes, such as the conversion of forest or land currently used for food production into land used for fibre biomass production. Instead, the related land use must be designed to alleviate the harmful effects of desertification, contamination, flooding or mining, by using degraded soils and marginal land to cultivate underutilised biomass feedstocks which can restore soil productivity and enhance the provision of diverse ES. FIBSUN will address these challenges using a multidisciplinary and multi-actor approach involving research organisations, companies and a wide range of stakeholders in a co-creational process aiming at outcomes and long-term impacts promoting green transition in the EU.

Keywords: biomass,fibre,biorefinery,bio based,business model,value chain,ecosystem service,resilience,sustainability,climate change,soil,land use
At the Margins of Equality: A Theory of Vulnerability to Social Exclusion (MESE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

The COVID-19 pandemic has exposed our shared vulnerability to isolation, serving as a reminder that relations of marginalization and exclusion constitute significant obstacles to the achievement of a society in which everyone can fully participate and stand in relations of equality with each other. Moreover, empirical research has shown that marginalised individuals are being disproportionately disadvantaged by the Coronavirus emergency in several ways: they are the target of stigmatization and discrimination. And, although they are more likely to experience mental health issues and are typically exposed to serious health risks, they are not provided access to the same degree of medical care as other members of society. The current socio-political state of affairs, then, vividly illustrates how persons' vulnerability to social exclusion is one of the most pressing social justice challenges that liberal democracies must face. Building on my previous research on the justification and the value of equality, in this project I will contribute to the Horizon Europe strategic plan towards "creating a more resilient, inclusive and democratic European society" by developing the first-ever comprehensive liberal egalitarian theory of vulnerability to social exclusion in analytical political philosophy. This theory will define the rights that marginalized individuals have to be fully included as equals in society and identify the social arrangements that the state ought to put in place in order to ameliorate their social condition. In our current pluralist and diverse societies the call for social equality is ubiquitous but its precise meaning is contested. By providing an account of what shape equality takes when applied to socially marginalized groups, this research will thus fill an important theoretical and normative gap when thinking about what a just society owes to its most vulnerable members if they are to be considered and treated as equals.

Keywords: liberalism social equality social exclusion vulnerability public policy
Multimodal 3D Holographic tool and real-time Guidance System with point-of-care diagnostics for surgical planning and interventions on liver and pancreatic cancers (HoloSurge)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Innovation actions
Countries involved: Norway,Netherlands,Belgium,United Kingdom,Hungary,Cyprus,Finland,Germany,Poland,Austria
Call: Harnessing the potential of real-time data analysis and secure Point-of-Care computing for the benefit of person-centred health and care delivery (HORIZON-HLTH-2023-TOOL-05, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 7677490.0
EU funding (EUR): 6806755.76
Participants: 15
Project status: SIGNED

Perioperative care is an intricate process that encompasses 1) preoperative evaluation, surgical planning and preparation; 2) intraoperative procedure; and 3) postoperative management. Perioperative care depends on clinical decision-making, a continuous process that involves many healthcare professionals (incl. radiologists, surgeons, anaesthesiologists, nurses, and others) who – based on the best available evidence, clinical experience, and the patient's individual circumstances – make informed decisions on the best course of action. Even though advancements in medical imaging modalities (CT, MRI, ultrasound) have greatly improved surgical outcomes, their interpretation towards deciding a specific course of action remains subjective. In addition, these modalities have several limitations when used alone (e.g., missed lesions; cannot provide a 3D visualization of key structures such as vessels), ultimately failing to provide a full picture of the patient’s anatomy that is shared and unambiguously understood by all in the assigned team. Due to these limitations, there are often suboptimal decisions that add to a cumulative risk of surgical complications in perioperative care. HoloSurge is a joint undertaking that brings European scientists and clinicians from high-tech companies, clinical centres, and research institutions in a consortium to deploy an innovative AI-based medical system that: i) enables automatic fusion and segmentation of state-of-the-art imaging modalities for interactive 3D holographic visualization of patients’ organs; ii) provides real-time surgical navigation; and iii) allows real-time cell-level cancer diagnostics. The solution will provide surgical teams with an unmatched holistic view of the patient’s anatomy and pathology in real-time at point of care, before and during surgery. This innovation will be validated for cancer interventions, while creating a trail of better-informed perioperative decision-making that can save countless lives.

Keywords: pancreatic liver cancer surgery tumour resection endoscopic interventions surgical navigation ai 3d holographic models model to patient registration real time data hyperspectral imaging
pre-Normative Research on Hydrogen Releases Assessment (NHyRA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Italy,France,Spain,Poland,Germany,Belgium,United States,Norway,United Kingdom
Call: Pre-Normative Research on the determination of hydrogen releases from the hydrogen value chain (HORIZON-JTI-CLEANH2-2023-1, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2086683.75
EU funding (EUR): 2086683.75
Participants: 15
Project status: SIGNED

How much hydrogen (H2) is released from the value chain? To answer the question is very challenging since insufficient and, when available, no standardized data can be found in the literature. However, it is essential to cover this knowledge gap to perform any credible and scientifically validated research regarding the H2 value chain impact on the climate change. The literature is full of studies investigating and calculating the risk of H2 leakages in case of failures, accidents, and emergencies. But significant knowledge gaps exist about the amount of anthropogenic H2 (in the atmosphere) from the H2 value chain. The research community needs to address this by improving the capability to quantify small and large releases, delivering validated methodologies and techniques for measuring or calculating them. A universally accepted and open-access inventory is needed as soon as possible. Likewise, an open access and comprehensible tool that is easy to be used is also asked by the stakeholders to better quantify the leaks from the whole in H2 value chain while the momentum is fast gathering to upscale H2 energy applications. The NHyRA project is specifically designed to address these urgent needs. The project will deliver a "H2 releases" inventory to serve as a reference for the scientific and industrial community. New or adequately adapted experimental, theoretical, and simulation methodologies will be validated to perform laboratory or in-field measurements to achieve the ambitious goal. Experimental tests will also be performed on the most critical elements of the H2 value chains by the partners of the Consortium. A complete picture of the H2 releases' scenarios in the middle (2030) and long (2050) term will be developed to enable decision-makers to identify and prioritize effective mitigation actions. And finally, the project will formulate recommendations for Standards and Technical Specifications.

Keywords: hydrogen releases,hydrogen releases detection,hydrogen releases secnario,hydrogen releases quantification methodologies,hydrogen releases inventory