Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Evolutionary and developmental origin of the nervous system (Neurostella)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Duration (months): 24.0
Total project cost (EUR): 178156.8
EU funding (EUR): 178156.8
Participants: 1
Project status: TERMINATED

Little is known about the genetic and developmental mechanisms that led to the evolution of the nervous system in the ancestors of eumetazoans. We plan to address the issue by studying a basal metazoan - the cnidarian Nematostella vectensis. The cnidarians are a sister group to bilaterians and possess a surprising complexity of genetic network, yet a relatively simple overall morphology including a diffuse nervous system. By studying the neural progenitors, we aim to address the problem from a developmental point of view. We propose to employ the state-of-the-art technology (transcriptome sequencing, in vivo imaging, transgenesis) in order to gain insight into the molecular characteristics of neural progenitors of Nematostella and to understand how the different populations of neural progenitors relate to neuronal diversity present in Nematostella. We will also analyse the function of a neural progenitor marker SoxB2, among others, in order to determine the role in the genetic hierarchy of the formation of the first nervous systems. Last, we will perform a comparative analysis of Nematostella neural progenitor make up with other cnidarians and bilaterians. This will elucidate the common and distinct features of cnidarian and bilateral nervous systems, which in turn will enable us to reconstruct the common ancestor.

Keywords: development,neurogenesis,cnidarians,neural progenitors,evolution,soxb2
How Old and New Media Influenced Each Other and Society in Iceland during the 16th and 17th Centuries (Old and New)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 166156.8
EU funding (EUR): 166156.8
Participants: 1
Project status: CLOSED

The influence of a the new medium of print on the old, existing medium of handwriting has never been examined before. The printing press came already around 1530 to Iceland and the earliest printed books were strongly influenced by handwritten manuscripts, which is well documented. A phenomenon which has not yet been analysed is that, as time went on, books in return influenced manuscripts. Manuscript production did indeed not stop after 1530, but grew to new quantitative and qualitative heights, including features of printed books such as title pages. I therefore propose to conduct a study on the relationship between books and manuscripts of the 16th and 17th centuries. The focus will be on title pages, as they are a truly innovative feature of printed books that we also find in post-Gutenberg manuscripts. The objectives of this project concern: a) The influence of a new medium on an existing medium b) The utilisation of features of the new medium to achieve specific aims and goals c) The impact of this utilisation on society Methods to conduct the study of title pages and their sociological impact include content analysis from literary studies, quantitative codicological analysis from book and manuscript studies, and iconographic/iconologic analysis from art history. This project has ground-breaking potential. It will provide insight into the ways features of new media were incorporated into existing media and how they were utilised. It will be the first systematic survey of its kind in Iceland and, concerning the influence of printed books on post-Gutenberg manuscripts, internationally. It will also be one of the first systematic interdisciplinary studies. It will be the forerunner of a larger project about Icelandic book and manuscript history and media changes with more researchers involved. The beneficiary has perfect conditions for interdisciplinary research and career development at the host institution and secondment and will complete the first step toward a full professorship.

Keywords: icelandic manuscript culture,icelandic print culture,media change,media and society
Stability Under Process Variability for Advanced Interconnects and Devices Beyond 7 nm node (SUPERAID7)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,France,United Kingdom,United Kingdom
Call: Generic micro- and nano-electronic technologies (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 3377527.5
EU funding (EUR): 3377527.5
Participants: 7
Project status: CLOSED

Among the physical limitations which challenge progress in nanoelectronics for aggressively scaled More Moore, process variability is getting ever more critical. Effects from various sources of process variations, both systematic and stochastic, influence each other and lead to variations of the electrical, thermal and mechanical behavior of devices, interconnects and circuits. Correlations are of key importance because they drastically affect the percentage of products which meet the specifications. Whereas the comprehensive experimental investigation of these effects is largely impossible, modelling and simulation (TCAD) offers the unique possibility to predefine process variations and trace their effects on subsequent process steps and on devices and circuits fabricated, just by changing the corresponding input data. This important requirement for and capability of simulation is among others highlighted in the International Technology Roadmap for Semiconductors ITRS. SUPERAID7 will build upon the successful FP7 project SUPERTHEME which focused on advanced More-than-Moore devices, and will establish a software system for the simulation of the impact of systematic and statistical process variations on advanced More Moore devices and circuits down to the 7 nm node and below, including especially interconnects. This will need improved physical models and extended compact models. Device architectures addressed in the benchmarks include especially TriGate/ΩGate FETs and stacked nanowires, including alternative channel materials. The software developed will be benchmarked utilizing background and sideground experiments of the partner CEA. Main channels for exploitation will be software commercialization via the partner GSS and support of device architecture activities at CEA. Furthermore, an Industrial Advisory Board initially consisting of GLOBALFOUNDRIES and STMicroelectronics will contribute to the specifications and will get early access to the project results.

Keywords: process variations systematic and stochastic,process simulation,device simulation,interconnect simulation,compact model,circuit simulation,physical model,correlations,extended cmos,nanowires
Improving European VoD Creative Industry with High Efficiency Video Delivery (Film265)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Content technologies and information management: ICT for digital content, cultural and creative industries
Action type: Innovation actions
Countries involved: Germany,Germany,France,Denmark
Call: Support the growth of ICT innovative Creative Industries SMEs (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2016-06-30
Duration (months): 18.0
Total project cost (EUR): 1131934.75
EU funding (EUR): 908851.0
Participants: 4
Project status: CLOSED

Film265 delivers a comprehensive approach to support European small and medium VoD services with the most innovative technology in video delivery. It aims at providing them with the technological edge needed to compete in the international market of film distribution in the internet. The core of Film265 is to adapt a HEVC/H.265 video codec for VoD scenarios, including a decoder integrated into a video player and an encoder integrated into a transcoding application in the cloud. This development will be supported by a comparison of HEVC/H.265 with current solutions that uses H.264/AVC for full length real-life film material. In order to assess feedback on the user demands and needs of the resulting video playouts Film265 will develop statistic tools that allow to determine the Quality of Experience by measuring buffering times, performance, delivery rate, the time watched etc. The tool will mainly consist of a plugin and a player that can be used by any VoD service around the globe. Finally, in order to create a fully market-ready solution, we will create APIs that allow all relevant industry participants to make use of what we have developed. The consortium consists of one university: TU Berlin (Germany), and three SMES: Reelport (France/Germany), Cinando (France) and LevelK (Denmark). TU Berlin (AES group) has an extensive experience on efficient implementations of video codecs, Reelport is a VoD provider for film festivals and other film-related projects. Cinando handles the market of the Cannes FIlm Festival, and LevelK is a Danish film distributor using VoD technologies. TU Berlin will provide the new video codec; Reelport its existing PicurePipe solution cloud encoding solution, and the new quality analysis tool; and Cinando and LevelK will integrate the new technologies into their VoD solutions, and will provide feedback about the efficiency and quality obtained by using the new technologies.

Keywords: h 265,hevc,video on demand,quality of experience,digital cinema,video streaming,video codecs
Electric Field Assisted Dynamic MOF alignment and Crystal Assembly (DYNAMOF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1964345.0
EU funding (EUR): 1964345.0
Participants: 1
Project status: SIGNED

Despite the staggering number of reports on Metal-Organic Frameworks (MOFs), we are still greatly limited in our ability to manipulate colloidal MOF particles and control MOF orientation. Reliable control of MOF crystal orientation is extremely important as the properties and functionality of most MOFs are highly dependent upon crystallographic direction due to lattice anisotropy. However, the effective exploitation of such functionality remains frustratingly out of reach. Based on the novel concept of exploiting MOF anisotropic ion mobility and polarizability, DYNAMOF aims to establish a flexible toolbox of methods for both dynamic and static control over the orientation, alignment and deposition of MOF crystals, which can be integrated into other processing techniques, thus paving the way for major advancements in the performance of MOF materials, composites and devices. The mechanisms of E-field alignment of MOF particles as well as colloidal interactions governing MOF plastic or liquid crystal assembly, non-classical crystal growth and oriented film formation will be studied to develop a comprehensive and revolutionary platform for orientational control of free-standing and supported MOF crystals. As a proof-of-concept, the implications of MOF alignment on the proton conduction of MOF composites will be tested to pave the way towards next-generation MOF proton exchange membranes. This ambitious project, which straddles the disciplines of materials science, chemistry and physics, is expected to break new ground by removing a key barrier in our ability to manipulate MOF particles. The wider goal of DYNAMOF is to establish the principles and working methods for colloidal manipulation across a wide materials spectrum, by using MOFs as a versatile platform for expanding our understanding of colloidal materials. Given the ubiquity and importance of colloids in materials science and daily life, the success of DYNAMOF will therefore have far reaching impact.

Keywords: colloidal assembly,liquid crystals,electrophoretic deposition,metal organic frameworks,proton conductivity
Oxidative stress and platelet hyperactivity: the role of NADPH oxidases in haemostasis regulation in health and diabetes. (POSTA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

Platelets are circulating blood cells that help to arrest of bleeding (i.e. haemostasis) and promote the repair of blood vessels following injury. In type 2 diabetes mellitus (T2DM), platelets are hyperactive and their uncontrolled activation leads to the unwanted occlusion of blood vessels (i.e. thrombosis). Thrombosis is the main cause of mortality for T2DM patients, who display significantly higher risk of cardiovascular disease than the rest of the population. Currently, 70% of T2DM patients succumb to cardiovascular diseases. I have been working on pro-oxidant enzymes called NADPH oxidases (NOXs), which are responsible for oxidative stress and activation of platelets. I have shown that the enzymatic activity of NOXs generates oxidant molecules (i.e. free radicals), which in turn are responsible for platelet activation. In preparation to this application, I have generated data showing that platelets from T2DM patients contain higher levels of the NOX1 isoform. This enzyme is responsible for oxidative stress and hyperactivity of platelets from T2DM platelets compared to healthy controls. In this project, I aim to understand the molecular mechanisms underlying platelet regulation by NOXs and the contribution of NOX1 to platelet hyperactivity in T2DM. I will use human blood from T2DM patients and murine models of T2DM. In addition to clarifying the role of NOX1 in the vascular complications of T2DM, I will test whether NOX1 inhibitors synthesised in my laboratory can protect the health of the vascular system in this disease. Taken together, this project will markedly advance our understanding of how platelets are regulated and will generate novel information on the link between cardiovascular risk and T2DM, which may result in a substantial improvement of the clinical management of this disease.

Keywords: diabetes,platelets,oxidative stress,thrombosis,cardiovascular risk
Novel therapeutic approaches for the treatment of cystic fibrosis based on small molecule transmembrane anion transporters (TAT-CF)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Spain,Italy,Spain,Hungary,Denmark
Call: New therapies for rare diseases (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 4591287.5
EU funding (EUR): 4591287.5
Participants: 8
Project status: CLOSED

This project will develop an innovative therapeutic approach for the treatment of Cystic Fibrosis (CF). This condition originates from the defective function of the CFTR protein, a chloride and bicarbonate permeable transmembrane channel. This project will evaluate small molecules capable of facilitating the transmembrane transport of anions such as chloride and bicarbonate and will thus enable CF treatment by replacing the missing CFTR anion permeation activity. This represents an unexplored path in the treatment of CF and a paradigm shift with respect to current strategies searching for a cure for CF. Instead of focusing on the development of mutation-specific treatments, we plan to develop a therapy applicable to CF patients, regardless of the type of mutation they harbor. Thus, this therapeutic approach overcomes the limitation of current mutation-specific treatments and is applicable to CF patients in general. To achieve this goal we have set up a comprehensive program to validate a research concept and complete the preclinical development of a new lead compound, making it ready for early clinical development. A rmultidisciplinary team of qualified researchers have been assembled to bring to conclusion a truly translational project from the synthesis of new compounds to validation on animal models. Cystic Fibrosis affects more people than any other rare disease. Therefore, it could be said, at least in quantitative terms, that CF qualifies as the main target of the topic. This project aims to complete the preclinical development of novel, innovative drugs based on a radically new concept in Cystic Fibrosis therapies. This result fully addresses the expected impact set out in the work programme of advancing the development of new therapeutic options for patients living with rare diseases as well as contributing to reach the IRDiRC objective to deliver 200 new therapies for rare diseases by 2020.

Keywords: cystic fibrosis,preclinical development,drugs,medicinal chemistry,biophysics,electrophysiology,drug delivery,lung disease,anion transporters,therapy,small molecules,compound optimization
REuse and REcycling of CDW materials and structures in energy efficient pREfabricated elements for building REfurbishment and construction (RE4)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies enabling energy-efficient systems and energy-efficient buildings with a low environmental impact
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Italy,Italy,Germany,Italy,Italy,Italy,Taiwan, Province of China,Belgium,Sweden,Sweden,Czechia,United Kingdom,United Kingdom
Call: New technologies and strategies for the development of pre-fabricated elements through the reuse and recycling of construction materials and structures (H2020-EEB-2016, 2016)
Start date: 2016-09-01
End date: 2020-02-29
Duration (months): 42.0
Total project cost (EUR): 5117523.75
EU funding (EUR): 4808148.75
Participants: 18
Project status: CLOSED

The overall goal of the RE4-Project is to promote new technological solutions for the design and development of structural and non-structural pre-fabricated elements with high degree of recycled materials and reused structures from partial or total demolition of buildings. The developed technology will aim at energy efficient new construction and refurbishment, thus minimizing environmental impacts. The RE4-Project targets the demonstration of suitable design concepts and building elements produced from CDW in an industrial environment, considering perspective issues for the market uptake of the developed solutions. The technical activities will be supported by LCA and LCC analyses, certification and standardization procedures, demonstration activities, professional training, dissemination, commercialisation and exploitation strategy definition, business modelling and business plans. The overarching purpose is to develop a RE4-prefabricated energy-efficient building concept that can be easily assembled and disassembled for future reuse, containing up to 65% in weight of recycled materials from CDW (ranging from 50% for the medium replacement of the mineral fraction, up to 65% for insulating panels and concrete products with medium mineral replacement coupled with the geopolymer binder). The reusable structures will range from 15-20% for existing buildings to 80-90% for the RE4-prefabricated building concept.

Keywords: construction and demolition
SPHERICAL MULTILAYER “RADAR DOME” (RADOME)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Radar is an essential tool for air traffic control and safety. Government agencies are pressuring the industry to produce systems that can monitor broader areas of the sky simultaneously and offer images with higher resolution and precision. The purpose is to enhance passenger safety and improve traffic control within their countries. All technological improvements made to radar are particularly affected by a structure called “radome”, which must be installed around the radar installation in order to protect it. “Radome” is a contraction of the two English words "radar" and "dome". It is therefore clear that it provides special protection of the antenna, whatever its type, but must cause minimal attenuation of the EM signal, both transmitted and received. For this reason, the trend is to build radomes that are as thin as possible, and are also self-supporting; i.e., without using metal supports that distort the signal. This creates a problem when designing the radome: on the one hand, it must be as electromagnetically transparent as possible; on the other, the entire structure must be sufficiently sturdy. Radar manufacturers plan to market antennas for civil air traffic control that operate at much higher frequencies than those currently used, since the former provide the higher resolution required. This type of antenna is already available; however, it cannot be used for air traffic control because the structure that covers it causes signal losses that are intolerable in this application. Thanks to a multidisciplinary approach employing new materials, nanotechnology and advanced simulation technologies, our project will launch on the civil air traffic control market an innovative, spherical, self-supporting radome that can operate at 26 GHz. By overcoming the current limitations of radomes, we will make an important contribution to the diffusion of new, high-frequency radar equipment and therefore to increasing air traffic safety and efficiency.

Keywords: radome,radar,air traffic control,safety,signal losses