Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Covalent-ligation-assisted elucidation of protein-aromatic foldamer interactions (PROFOLIG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

The development of ligands that selectively bind to a given protein surface is a challenging area of research with potential applications in diagnostics, pharmacology or therapy. Current approaches include small molecule screening, the design of medium sized epitope mimetics (e.g. alpha helix mimetics) and directed evolution methodologies (e.g. ribosome display). In this project, we intend to initiate an essentially unexplored approach: the design from first principles of synthetic ligands derived from helical aromatic oligoamide foldamer backbones bearing proteinogenic side chains to target the surface of a given protein: interleukin 4 (IL4). Helical aromatic amides appear to be well suited for this purpose thanks to their predictable, tunable and stable conformations in solution; their relatively easy synthesis of secondary and tertiary-like structures as large as small proteins; and their high amenability to crystal growth and structural elucidation. Specifically, we intend to explore molecular recognition rules between large (2-15 kDa) aromatic oligoamide foldamers and a target protein surface, and to validate a novel iterative method based on combining covalent attachment and structural characterization. The proposed strategy thus consists in structure-based iterative design. The following steps will be implemented: 1) synthesis of a small pool of foldamer sequences; 2) covalent attachment of each of them via a disulfide bridge to the surface of a recombinantly expressed IL4 cystein mutant, and screening for foldamer-protein interactions through foldamer helix handedness induction by the chiral protein surface; 3) structural characterization of the interactions, mainly by crystallography, within selected protein-foldamer adducts; 4) design of new and improved foldamers. Ultimately optimized interactions should produce foldamers that bind to IL4 without the assistance of the covalent tether.

Keywords: foldamers,molecular recognition,proteins
Intelligent storage and transport solutions with integrated monitoring to optimize the international fresh produce supply chain, significantly increasing shelf life and preventing food waste (Perfect Fresh)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: France
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Janny MT is a French enterprise highly recognized in the fresh produce preservation sector with vast experience offering storage solutions. Now, the company seeks to strengthen its position in storage and break into the transport sector with an innovative concept called Perfect Fresh. Its unique micro perforated membrane and advanced sensors are easy to use and environmentally friendly. Its products Module (storage) and Bag (transport) are capable of maintaining fresh produce in a micro controlled atmosphere with < 5% CO2/O2 concentrations. This significantly increases the produce´s shelf life as well as avoids weight losses. The advantages are that food waste is reduced, air freight is substituted by sea/rail transport and peak production is better managed. Additionally, the integrated monitoring system will connect the entire value chain from farm to store, providing key information to growers, distributors and retailers. This project will firstly target high value perishables, such as berries, mushrooms, tropical fruits and flowers. These segments have a growing demand worldwide and urgently need a solution to optimize their supply chain in order to limit price fluctuation, lower their carbon footprint and increase their freshness & quality. The envisaged solutions will propel Janny MT to become a global reference in the market for sustainable storage & transport of perishables as well as become a data-driven company offering added value services. Perfect Fresh will revolutionize the sector, enabling a Swede to savour Ecuadorian tree-ripened mangoes and an Italian to enjoy freshly cut Dutch tulips at competitive prices. The objective of this SME proposal is to seek funding to finish developing an innovative transport solution and a monitoring platform as well as to elaborate a complete business plan including a targeted marketing strategy. The feasibility study results will be used to guide market uptake and consequently the company´s growth.

Keywords: micro controlled atmosphere,innovative fresh produce transport solution,shelf life increase,integrated monitoring system,prevention of food waste,reduction of carbon foot print
Positron Emission Tomography in Agriculture and Life: PET for the study of wheat growth in biotic and abiotic stress (PETAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Italy,Italy,Italy,Belgium,China
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-10-01
End date: 2026-05-31
Duration (months): 56.0
Total project cost (EUR): 593400.0
EU funding (EUR): 547400.0
Participants: 6
Project status: SIGNED

The growth and yield of major cereals represents one of the key issues in food security, due to the abiotic andbiotic stress caused by climate change and desertification. PETAL proposes to measure the early changes of CO2 metabolism and water transport induced by stress in wheat using Positron Emission Tomography (PET). Novel functional imaging data correction andanalysis models are developed in order to have a quantitative interpretation of the PET images of wheat obtained with the RAYCAN digital E180 preclinical PET/CT scanner, the MOLECUBES beta- PET/CT preclinical scanner, a dedicated digital portable plant PET system and a portable Table-Top PET/ MRI scanner. Functional imaging data, conventional morphological and proteomics data and CT root images willbe collected at each stage of growth of the wheat under defined stress condition and after biostimulant treatment.This unprecedented unique dataset will be analyzed using new High-Performance Computing approaches,in order to define a new set of measurable quantities, which are affected by stress at the early stage of the plant development. On this basis, the PETAL consortium will generate a SME/academic platform providing servicesfor wheat growth early analysis in agriculture. PETAL builds on the cross-disciplinary expertise of the partners in physics, technology, biology,agronomy, ecology, computing and software systems. Researchers involved in the 38 secondments will participate to the validation of PET as imaging technique for plants, to thedevelopment ofnovel PET data analysis algorithms and technologies, to the data collection and analysis. They will be trained in new technologies, experimental techniques in agriculture, data analysis, and algorithm implementation, in order to establish a multi- disciplinary working chain train personnel, and therefore prepare the sustainability of the project proposal. To complete the training offer, 3-montly webinars and yearly workshops are organized.

Keywords: positron emission tomography,biotic and abiotic stress,data modelling in agriculture
Do intermediate-mass black holes exist? (imbh)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 1999975.0
EU funding (EUR): 1999975.0
Participants: 2
Project status: CLOSED

With this proposed project I will determine whether intermediate-mass black holes (IMBHs) exist. I propose to use ESA's new Gaia mission, the rich Hubble Space Telescope data archive, and state-of-the-art techniques to investigate systems predicted to exist but not yet found hitherto, such as recoiled hyper-compact stellar systems, red-supergiant mass donors to ultra-luminous X-ray sources, and white dwarf tidal disruption events. The latter can only be detected if black holes with masses less than 1E5 Msun are involved. Using these systems and events we can probe the sphere of influence of the IMBH and determine the black hole mass dynamically. Currently, there are strong indications for the existence of IMBHs, but dynamical evidence, the irrefutable proof of their existence, is still lacking. Whereas the unequivocal detection of an IMBH will be a breakthrough discovery in itself, it has also important consequences for searches of dark matter annihilation signals, it will provide a baseline for the rate predictions of gravitational wave radiation events involving IMBHs, and the properties of a population of IMBHs provides important constraints on the growth of supermassive black holes and galaxies. Finally, if we discover IMBHs in hyper-compact star clusters it validates numerical relativity simulations that predict that merging black holes receive a recoil kick. My membership of Gaia's Data Processing and Analysis Consortium gives me a distinct advantage in analysing and interpreting Gaia data that, through the superb angular resolution, immediate spectroscopic observations and all-sky coverage, provides unique capabilities ideally suited for answering the question whether IMBHs exist. My proposed project is the first to recognize the potential of Gaia (WP1&2) as well as the implications of having red supergiant mass donors in some ultra-luminous X-ray sources (WP3) for answering the question on the existence of IMBHs.

Keywords: black holes
A Thermal-Visual Integrated System Mounted on an Unmanned Aerial Vehicle for 3D energy performance mapping and forecasting and damage evaluation (TherVIS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Objective of this project is the implementation, validation and demonstration up to the commercial phase of an innovative and flexible device mounted on an Unmanned Aerial Vehicle (UAV), named in the following TherVIS. The device is suitable for: i) mapping energy building performance for energy saving within large extent areas (e.g. building blocks, districts, small communities), ii) evaluating structural health of civilian infrastructures (including bridges, new, old and historical buildings, pipelines, etc.) for public security. The age of existing buildings is rising and, as a result, they continuously undergo degradation. The improvement of the energy consumption efficiency of buildings and their environmental impacts is a general issue of increasing importance for the construction industry in Europe and all over the world. For minimizing energy losses TherVIS device is proposed, consisting in a monitoring device integrating a new generation thermal camera coupled with a stereo camera or laser scanning. The monitoring system is mounted on a micro-UAV equipped with different navigation sensors, stabilized by a microcontroller-based flight control and basically operated by GPS navigation or manual remote control. An innovative methodology would be implemented allowing the 3D aerial pictures and thermal images, acquired at a high sensitivity rate, high speed and low frequency, to be automatically integrated in a combined 3D spatial-thermal image within a purposely-built model. Using in situ measured meteorological conditions, the model would allow for quantification of local energy losses and for detection of structural damages of the building. This approach would lead, within large extent areas (e.g. building blocks, districts, small communities) and with a limited number of images (i.e. low operating costs), to: i) an automatic cracking pattern recognition and to ii) a smart 3D spatial-thermal mapping for energy performance assessment.

Keywords: building energy performance,thermal camera,structural health
European Long-Term Ecosystem and socio-ecological Research Infrastructure (eLTER)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Spain,Israel,Germany,Germany,Germany,Spain,Italy,Germany,Austria,Serbia,Bulgaria,Finland,Greece,Romania,Slovakia,Sweden,Belgium,Hungary,Poland,Slovakia,Slovenia,Latvia,France,Czechia,Netherlands,United Kingdom,Portugal
Call: Integrating and opening existing national and regional research infrastructures of European interest (H2020-INFRAIA-2014-2015, 2014)
Start date: 2015-06-01
End date: 2019-10-31
Duration (months): 53.0
Total project cost (EUR): 4999138.0
EU funding (EUR): 4999138.0
Participants: 33
Project status: CLOSED

A collective effort is needed to create the environmental research infrastructure for answering pressing questions in a world of rapid social, economic and environmental change. The overall aim of the eLTER project is to advance the European network of Long-Term Ecosystem Research sites and socio-ecological research platforms to provide highest quality services for multiple use of a distributed research infrastructure. eLTER´s major objectives and methods are to: (1) identify user needs for the research infrastructure in relation to major societal challenges through consultations with scientific, policy and business stakeholders and horizon scanning; (2) streamline the design of a cost-efficient pan-European network, able to address multiple ecosystem research issues, in collaboration with related global and European research infrastructures, e.g. LifeWatch; (3) develop the organisational framework for data integration and enable virtual access to the LTER data by enabling data publishing through distributed Data Nodes and by providing access to data on key research challenges through a Data Integration Platform; (4) foster the societal relevance, usability and multiple use of information, data and services through new partnerships with the providers of remotely sensed data, analytical services and scenario testing models, and via the adoption of new measurement technologies. The LTER-Europe network and the European Critical Zone community will collaborate to achieve these goals. 162 sites in 22 countries will provide data on long-term trends in environmental change, some reaching back 100 years. Test cases using these data will address a range of environmental and social issues to push innovation in network level services and steer conceptual developments. The envisaged “LTER Infrastructure” will enable European-scale investigation of major ecosystems and socio-ecological systems, and support knowledge-based decision making at multiple levels.

Keywords: ecosystem research,socio ecological research,research infrastructure,esfri,lter,ltser,lter infrastructure,critical zone,data integration platform,lter europe,deims
Folate-Target Nanodevices To Activated Macrophages For Rheumatoid Arthritis (FOLSMART)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Ensuring the safe and sustainable development and application of nanotechnologies
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Germany,Germany,France,Portugal,Portugal,Portugal,Portugal,Portugal
Call: Novel nanomatrices and nanocapsules (H2020-NMP-PILOTS-2015, 2015)
Start date: 2016-01-01
End date: 2020-12-31
Duration (months): 60.0
Total project cost (EUR): 4993833.75
EU funding (EUR): 4993833.75
Participants: 11
Project status: CLOSED

FOLSMART will bring to phase I clinical trials novel folate-based nanodevices (FBN) for the treatment of rheumatoid arthritis (RA). These nanodevices for folic acid (FA)-mediated targeting of activated macrophages showed improved clinical scores in a mouse model of RA when compared to methotrexate (MTX), first-line drug therapy for the treatment of RA. In this way, FBN will be benchmarked against this drug. MTX has significant associated toxicity and second-line biological therapies pose a great economic burden to hospital/public health systems. In parallel, nanodevices encapsulating Sulfasalazine (SSZ), will be tested. SSZ is a second line indication for the treatment of RA, unresponsive to MTX or MTX–intolerant patients. Furthermore, FOLSMART proposes the optimization of mechanisms for the release of the drugs, through pH and temperature-sensitive nanodevices. Exploitation and business plans will be elaborated. In parallel, the initial economic evaluation of all proposed treatments will be performed to validate these claims. Specific technological objectives of FOLSMART will be: Good Manufacturing Practice (GMP) production of the FBN based therapies which have been positively bench-marked in the previous FP7 European project NANOFOL in comparison with the use of MTX in a RA mouse model: -Liposomal MTX and SSZ with FA-“neck domain” peptide as targeting agent -Nanoparticles from HSA-FA/MTX conjugates and SSZ -Optimization of mechanisms of drug release and application to other fields Pre-clinical development on RA models: -Toxicology and pharmacokinetics, to determine tolerability and efficacy benefit in two animal models rat and dog, under Good Laboratory Practice (GLP) standards -Genotoxicity and Carcinogenicity Preparation for Phase I clinical trial of the best therapies bench marketed against MTX: -Nanodevices with MTX and SSZ will offer improved tolerance and greater efficacy meaning that patients who do not do well on MTX will have cost-effective alternatives

Keywords: rheumatoid arthritis,folate based nanodevives,macrophages,methotrexate,sulfasalazine,nanofol
Innovation Management Capacity Building of SME by the Enterprise Europe Network Baden-Württemberg 2 (BW-KAM2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Germany,Germany,Germany,Germany,Germany,Germany
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 504596.0
EU funding (EUR): 504596.0
Participants: 11
Project status: CLOSED

SMEs are the driving force of economic growth and job creation in Europe: 20.7 million SMEs in the non-financial business economy make up ~99% EU enterprises. 85% of new jobs in the private sector created by SMEs provide more than two thirds of total jobs (more than 87 million). And SMEs account for more than 58% of the total gross-value added in Europe. For SMEs, the backbone of European industry, H2020 is looking into completely new funding measures and project types. The new SME instrument, which is used by the various industrial and societal programme lines in H2020, offers not only a new 3-phase project development and implementation - from idea validation to market. It also offers those SMEs which win the race and receive funding, a new form of accompanying support: key account managers and coaches, which are meant to help SMEs keep track of their target for growth through innovation. By providing key account management and enhanced innovation services, the overall objective of the BW-KAM2 project is to enhance the innovation management capacity of SMEs in the geographical region of Baden-Württemberg, Germany, which is also the geographical area covered by the Enterprise Europe Network Baden-Württemberg. BW-KAM2 will target SME beneficiaries in the SME Instrument, which are located in Baden-Württemberg as well as high potential SME with strong innovation activities and high potential for internationalisation and growth. BW-KAM2 will deliver up to 120 service packages.

Keywords: innovation management
Monitoring meat texture to optimize slicing yield and reduce wasted meat in high-speed slicing lines (SLICEWATCH)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-2-2015, 2015)
Start date: 2016-05-01
End date: 2018-10-31
Duration (months): 30.0
Total project cost (EUR): 1731961.25
EU funding (EUR): 1212372.88
Participants: 1
Project status: CLOSED

The EU-28 meat processing industry generates an annual turnover of €160b, with 50% corresponding to SMEs. Over recent years, the production of sliced meat products has grown steadily, driven by increased consumer demand for ready-to-eat products, including cooked and dry-cured ham. Despite significant efforts made by processors to optimize the process, around 10% of meat is wasted during slicing, which amounts to t72,000/year of meat wasted in EU slicing lines. The presence of soft and exudative textures (PSE) in meat is responsible for a major fraction of the meat loss during slicing. On average PSE meat represents yearly costs of €180k per slicing line, and €490m/year for the EU sector as a whole. At present, meat processors do not have an effective means to address this problem. SliceWatch aims to develop a commercial solution to evaluate meat texture in-line, non-invasively, and on a piece by piece basis. Based on a scanning technology developed, demonstrated, and patented by LENZ, meat processors will be able to sort raw meat pieces according to texture, and to reassign soft textured meat to products which are less sensitive to raw meat texture, e.g. sausages, hamburgers and other specialty products. This will enable processors to increase their slicing yield by 4% to 12%, and to reduce operating costs. With the support of an approved H2020 Phase I project, LENZ successfully demonstrated the SliceWatch prototype in a pilot meat processing line and developed a business plan. The Phase II project will scale-up and validate the solution with meat processors to achieve TRL9, prior to commercialization. The project is an essential part of LENZ’s business strategy to develop industrial inspection solutions which provide cost savings for the meat processor companies. SliceWatch represents a unique business opportunity for LENZ to boost sales and access international markets, and to help our customers improve their business and achieve environmental benefits.

Keywords: food technology,meat processing,non destructive testing,electromagnetic scan