Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dissecting the molecular mechanisms of transgenerational epigenetic inheritance (MOMENTS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

Small RNAs have a remarkable regulatory role in most eukaryotes. These molecules bind to Argonaute proteins (AGO) and form a complex that recognizes its mRNA targets by sequence complementarity. The regulatory role is driven by the catalytic activity of AGO, but not exclusively. In several organisms, AGO recruits other factors to perform the silencing. Remarkably, during transcriptional gene silencing, the small RNA-AGO complex engages factors that interfere with transcription but also proteins that modify the DNA and the chromatin at the targeted loci. This phenomenon has been observed in plants, yeast, flies, and worms. Particularly, in the nematode Caenorhabditis elegans, this silencing regulation can be triggered and inherited by the next generations. This reveals the importance of small RNAs and chromatin modifications for transmitting non-genetic information and maintaining germline stability across generations. Several factors required for epigenetic inheritance have been identified by genetic screens in the worms. The nuclear Argonaute, HRDE-1, is expressed in the gonad and is a key component of this pathway. Still, what are the HRDE-1-associated factors required for transgenerational transcriptional silencing are not fully understood. This proposal aims to address what are the factors participating in the different stages of silencing mediated by HRDE-1: establishment, inheritance, and maintenance. To answer these questions, I will employ strains that allow the inducible depletion of the factors involved in the silencing response. I will combine these tools with encompassing genomics and proteomic approaches to investigate the changes across generations. This proposal will unveil the molecular mechanisms of transgenerational epigenetic inheritance. Moreover, this study will be instrumental for the study of these responses in other organisms, especially other nematodes, with potential applications to health and ecology.

Keywords: epigenetics gene silencing chromatin small rnas c elegans rna interference
Assessing Tourism Sustainability in the EU Region: A Quantitative Approach (TOURSUS-EU)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Portugal,Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-03
End date: 2025-07-02
Duration (months): 24.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 2
Project status: CLOSED

The TOURSUS-EU proposal is designed to contribute to the definition of and the transition to a more sustainable model of tourism, which is one of the major issues of the EU. As a highly interdisciplinary project, TOURSUS-EU intends to introduce a new approach to measuring the impact of mass tourism on the economy and society, by analyzing data from important tourist destinations listed in the UNESCO World Heritage sites (Venice, Lisbon and Split). The proposal relies on the use of state-of-the-art knowledge and state-of-the-art analytical methods (Dynamic Panel Models, time series analysis, MultiCriteria Decision Analysis and Big Data Analysis) in order to develop an innovative structured approach for the assessment and improvement in tourism sustainability. In particular, the project will allow for the quantitative evaluation of the effects of various factors on the negative developments in tourism sector, as well as the assessment of the sustainable growth in tourism that will take into account the negative effects that mass tourism generates. The expected results will be beneficial for both the scientific and the local community and will have an impact on the formation of management practices within tourist destinations, potentially to be adopted in other regions and tourist destinations in Europe and worldwide. The realization of the project TOURSUS-EU will be a turning point in my career. Considering BRU Iscte is a recognized multidisciplinary research center with Researches Excellence, I firmly believe that the proposed cooperation and TOURSUS-EU will open up the best future career possibilities for me. It will significantly help me to increase my expertise in the application of new relevant techniques in the field of sustainable tourism, allowing me to grow as an independent researcher.

Keywords: sustainability,tourism,econometric analysis,dynamic panel model,multicriteria decision analysis,big data
Quantum technology components for space communication (QuTechSpace)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Germany,Czechia,France,Netherlands
Call: Quantum Communication Technologies for space systems (HORIZON-CL4-2023-SPACE-01, 2023)
Start date: 2024-01-01
End date: 2026-10-31
Duration (months): 34.0
Total project cost (EUR): 3463971.19
EU funding (EUR): 2498261.08
Participants: 9
Project status: SIGNED

The goal of QuTechSpace is to push the development of key components for space quantum communication and to facilitate standardization of the technology. To this end, we will advance three core technology components: entangled photon source (EPS), prepare and measure (P&M) source, and the post-processing software for the QKD protocol. In particular, we will increase the performance parameters such as sending rates, reduce the size, weight, and power consumption (SWaP), and perform space qualification of hardware. The technology development will be accompanied by facilitating the standardization process of space quantum communication technologies and systems through active involvement in standardization bodies. By including European entities ranging from academics over new space companies and quantum technology developers to large system integrators, the joint European ecosystem will be included in the process and together we will work towards the joint goal of reaching European sovereignty in space quantum technologies. QuTechSpace will also take into account developments in the field of space quantum communication. The technology development will be completed through testing in relevant environment, reaching TRL 6. Furthermore, the different technology components will be tested together in an end-to-end implementation of the quantum chain in the laboratory, providing crucial insights into the heart of space-based quantum-communication systems. Finally, it is important to highlight that the developed components can be used for quantum key distribution as well as for realization of the quantum internet. QuTechSpace will conclude by giving an outlook and recommendations for future developments and implementations of quantum-communication systems.

Keywords: quantum key distribution,entangled photon source,prepare and measure source,post processing software,space based quantum communication,
UTU-ESR Programme: Solutions for Green and Digital Transition (UTU-GreDiT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Finland,Portugal,Sweden,Norway,United Kingdom,Canada,Germany,United States,France
Call: MSCA COFUND 2022 (HORIZON-MSCA-2022-COFUND-01, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 3360000.0
EU funding (EUR): 3360000.0
Participants: 27
Project status: SIGNED

UTU-GreDiT is a unique international, inter-sectoral and interdisciplinary Doctoral Programme hosted by the University of Turku (UTU). The objective of UTU-GreDiT is to provide a top-quality research training ecosystem for 25 ESRs focusing on Green and Digital Transition to strengthen transformative change. It boosts transformative change towards sustainable societies and producing high-demand experts for the needs of public-private sectors and academia. The call of the UTU-GreDiT Programme will be published internationally and applicants will be evaluated through an open, merit-based process by external evaluators. The appointed ESRs will be full members of UTU Graduate School (UTUGS) with similar opportunities, obligations and working conditions to other UTUGS members. UTU-GreDiT will integrate cutting-edge research infrastructures, experienced supervisors, and existing knowledge base of 14 research groups with >45 professors and experienced researchers. This enables ESRs to gain high-quality training and perform novel research under interdisciplinary supervision that crosses research groups from UTU and associated partners on topics related to Green and Digital Transition, and European Green Deal. National or international 4-6 months secondments and other training activities are provided through 26 associated partners and UTU. UTU-GreDiT will provide transferable skills for ESRs including scientific writing, project management, culture of open science and entrepreneurial skills that are essential for widening their career prospects. The training and secondments offered will actively involve all participants, and thus, contribute to bridging the gaps between research and private sector and boosting the sustainable socio-economic growth from regional to EU level. After training, ESRs will be capable of working in the private or public sector or academia, especially in the area of Green and Digital Transition, and have skills to start their own business, as well.

Keywords: green and digital transition,transformative change,sustainable socio economic growth,biodiversity,geodiversity,green deal
REduced or Single Pilot Operation iNcapacitation Safety Enhancement (RESPONSE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Ireland,Italy,Spain,Netherlands,Germany,France
Call: ATM application-oriented research for air–ground integration and autonomy (HORIZON-SESAR-2023-DES-ER-02, 2023)
Start date: 2024-09-01
End date: 2027-02-28
Duration (months): 30.0
Total project cost (EUR): 1999577.5
EU funding (EUR): 1999577.0
Participants: 6
Project status: SIGNED

The resilient growth of global air travel continues to lead to ever busier skies and airports, placing growing workloads on pilots and operators both in the air and on the ground, as well as increasing the demand for pilots globally. Addressing these concerns will require technological solutions, in the form of increasingly automated assistance systems to help alleviate pilot workload (reduced crew operation, extended minimum crew operations), as well as fully autonomous solutions which can support Single Pilot Operations (SPO) in the event of pilot incapacitation. On the other side, the adoption of new operational procedures such as SPO will have an impact on the ground operations and the ATC operators responsibilities. The RESPONSE consortium led by Collins Aerospace aims to deliver one TRL2 solution: safe return to land including pilot incapacitation. The proposed solution directly support pilots’ incapacitation transition monitoring and deliver an integrated air-to-ground SPO CONOPS to enhance safe return to land operations. In the project, the Consortium delivers a technology enabler as pilot incapacitation transition monitoring to detect pilot incapacitation and map cognitive states and degradation of human performance. The solution delivered is a safe return to land CONOPS introducing the role of air-to-ground digital assistants minimizing the required changes from dual pilot operations to SPO, including dealing with pilot incapacitation in the flight deck, with the impact on ATC operators tasks and with the role of human autonomy/AI teaming to support workload reduction. RESPONSE project builds on top of the outcomes and recommendations of SAFELAND project and will enhance the execution of current projects in SESAR3 Industrial Research, actively contributing to the future preparation and delivery of a full demonstrator for safe return to land in the case of SPO.

Keywords: single pilot operations,reduced crew operations,safe return to land,pilot incapacitation,digital assistants
Structure, Function and Regulation of Antimicrobial and Virulent Amyloids at High-resolution (FuncAmyloid)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: SIGNED

Self-assembly of proteins and peptides into amyloid fibrils produced across kingdoms of life is associated with antimicrobial activity, microbial pathogenicity, and a wide range of diseases. The correlation of fibrillation and morphology to function is poorly understood, and high-resolution structural information and mechanistic models are lacking. Our lab pioneered the atomic-level analysis of bacterial amyloids and eukaryotic functional fibrils involved in cytotoxicity, biofilm structuring, and antibacterial activity. We revealed novel morphologies extending beyond canonical amyloid cross-β structures of tightly mated β-sheets, to include, for example, cross-α fibrils composed on amphipathic α-helices. In addition, we exposed a unique lipid-induced cross-α/β secondary structure switch in fibrils of the same sequence. Here we investigate amyloid fibrils which serve as key virulence determinants in S. aureus and Pseudomonas acting as cytotoxins and in biofilm scaffolding, and as antimicrobials produced across different species. We will leverage the knowledge and expertise, and newly emerging methods in electron, light and force microscopy, to understand how fibrillation propensity, fibril morphology and structural switches are connected to function, membrane interactions and toxicity mechanisms at high resolution. The findings are expected to identify structural features that underlie the formation, regulation, and activity of these fibrils, providing advantages in specific environments. Understanding these structure-function relationships will help to clarify the link between amyloid formation and antimicrobial activity. We will use the insights gained from these studies for the rational design of antimicrobial peptides and small molecules targeting virulent determinants towards potential applications in the management of infectious diseases. Our findings on functional amyloids can overall advance life, material, medical and environmental sciences.

Keywords: amyloids,fibrils,self assembly,antimicrobial,virulence,structure,cryo em,cryo clem
Risk stratified care to reduce antibiotic use and AMR transmission in African hospitals (PediSEP1)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: United Kingdom,Kenya,Uganda,Malawi,Italy,Canada,United States
Call: Tackling Antimicrobial Resistance (AMR) through R&D in novel and existing antimicrobials (HORIZON-JU-GH-EDCTP3-2024-01-two-stage, 2024)
Start date: 2025-07-01
End date: 2030-06-30
Duration (months): 60.0
Total project cost (EUR): 5998992.5
EU funding (EUR): 5998992.5
Participants: 10
Project status: SIGNED

In suv-Saharan Africa (sSA), most government-run hospitals aim to follow WHO or national syndrome-based guidelines. Clinical syndromes, such as ‘severe pneumonia’ are designed to be sensitive for pathologies like invasive bacterial disease that require specific treatments to prevent death. However, low specificity means that a far wider group of children is captured by a syndrome definition including many with a self-limiting infection and very low risk of death. Currently, decisions regarding admission, discharge, and escalating or de-escalating antimicrobials are typically made by staff with limited paediatric training, very often interns, and current guidelines have very limited or no advice on de-escalation and discharge. These factors contribute to antimicrobial over-use, overly broad-spectrum prescribing, and unnecessarily prolonged treatment ‘to be on the safe side’. Excessive duration of antibiotic treatment means a greater risk of acquiring AMR from the hospital environment, significant costs to health providers and families, overcrowding, a low nurse:patient ratio, and reduced care for higher risk children. We propose that major reductions in antibiotic use, exposure to the hospital environment and transmission of AMR can be achieved by risk stratified care enabling very low-risk children admitted to hospital to be cohorted away from longer-stay patients, stop antibiotics and go home earlier with inexpensive phone follow up. We will engage policymakers, undertake mathematical modelling of antimicrobial usage, AMR transmission and costs across sSA within risk strataand conduct a trial of risk stratified care, and develop a tool 'PPS-plus' for monitoring of AMR transmission through simple cross sectional surveys. Relevance to the work programme includes combatting the major global threat from AMR through identification of personalised treatment options, a better evidence-base for policymaking, and digital tools to optimise clinical workflows.

Keywords: risk,cost,overcrowding,transmission,antimicrobials,personalised
Analysis of Molten Salt-Air Heat Exchangers for Large Scale Energy Storage Technologies (MAX4LES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark,Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 2
Project status: SIGNED

Molten salt-air heat exchanger thermal sizing design influences the performance and, in turn, the cost-effectiveness of a range of emerging technologies (such as concentrated solar power integrated pumped thermal energy storage, process heating, and high-temperature processes like H2 production) supporting the green transition. As per 2019 reports, worldwide power generation capacity from molten salt storage in CSP plants was 60 GWh (thermal) and is expected to rise several folds by 2030 [1]. The primary goal of MAX4LES is to develop and provide a scientific benchmark for the optimal design of molten salt-air shell and tube heat exchangers. I aim to identify the cause and effect of freezing and time required for melting the solidified molten salt inside the tubes of molten salt-air heat exchangers. And to propose selective coatings to avoid the salt deposition on the tubes to prevent clogging that might lead to reduced performance and/or cause structural damage. The project outcomes will bridge the existing knowledge gap and support the future development of molten salt-air heat exchangers. The training at the host, Technical University of Denmark, Denmark, secondment at Eindhoven University of Technology, Netherlands, and the short stay and cooperation with the industrial partner, Aalborg CSP, Denmark, will provide me with the ideal technical, ethical, and cultural exchange and significantly strengthen my future career prospects. The intersectoral approach will provide the basis for implementing the research outcomes commercially. Overall, the project will set a foundation for me to continue focusing my expertise and skills to contribute toward meeting the long-term European Union’s (EU’s) Net-Zero decarbonization goals by 2030.

Keywords: heat exchangers freezing melting computational fluid dynamics
Services for inter- and cross-disciplinary data discovery, access, sharing and reuse in the EOSC Federation (EOSC Data Commons)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: EOSC ecosystem
Action type: Research and Innovation actions
Partnership: EOSC (co-programmed)
Countries involved: Netherlands,Spain,Poland,Germany,France,Czechia,Italy,Croatia,Finland,Austria,Switzerland
Call: Innovative and customizable services for EOSC Exchange (HORIZON-INFRA-2024-EOSC-01, 2024)
Start date: 2025-04-01
End date: 2028-03-31
Duration (months): 36.0
Total project cost (EUR): 6999766.25
EU funding (EUR): 6999766.25
Participants: 22
Project status: SIGNED

The EOSC Data Commons project’s mission is to contribute to tThe EOSC Data Commons project’s mission is to contribute to the establishment of EOSC as the European Research Commons, a global trusted ecosystem that provides seamless access to high-quality interoperable research outputs and services that enable European researchers to collaborate more easily, be more productive and achieve higher levels of excellence. The project achieves this with innovative EOSC Exchange services for improving and accelerating data lifecycle management supporting discovery, analysis, deposition, preservation, sharing, use and reuse of research data in a European data and compute continuum that builds on the capabilities of the EOSC EU Node, national and European infrastructures for data-intensive research and a community of federated repositories from national, institutional and thematic initiatives. The project will deliver: (1) a AI-based Analytics-Oriented Metadata Warehouse and Discovery Service; (2) a federation of data repositories from different providers enriched by scientific applications and data analytics tools; (3) a Catalogue of data analytics tools (4) an Execution Service for tool deployment and execution; (5) metadata specifications for the reproducible and interoperable execution of analytic tools; (6) a FAIRness assessment and reproducibility toolset and related policies. Innovation is led by multidisciplinary and thematic use cases from Social Sciences and Humanities, Physics, Life Sciences, Biology, Heath and Medicine, and Environmental Science. The project’s pan-European consortium involves open source technology providers, major national and thematic data repositories, and user communities contributing to co-design, testing and validation with their use cases. By working with 12 national and institutional data repositories, the project has the ambition of delivering new solutions that will support the integration of Nodes in the future EOSC Federation.

Keywords: eosc exchange,open science,data discovery,federation of repositories,data analytics,use cases