Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Relevant Realism - Truth, Power, and Action for 21st Century Societies (RELEVANT REALISM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

The aim of this project is to develop a fully functional new concept of realism which intrinsically combines theories of truth with theories of action. This new theory will be measured against other contemporary approaches and adapted to current political problems to validate it and to investigate its practical applications. The problems underpinning the urgent need of developing a new concept of realism are, namely, the rise of authoritarianism and the apparent ineffectiveness of current truth-concepts and communicative strategies in countering totalitarian, authoritarian, and simplistic-populist discourses. The innovative, nostalgia-free concept of realism titled “relevant realism” will provide new ways to frame current political problems and new tools for political communication while avoiding both the current realist backlash and the postmodern relativist trap. The project will engage in a detailed analytic assessment of concepts of realism and a comparative analysis and fusion of positions in Neopragmatism, Poststructuralism, and adjacent theories. Providing a realist approach without losing sight of postmodern and poststructuralist contributions to disentangle and unveil the power-mechanisms involved in every truth-claim is of utmost interest for a culturally diversified space like Europe where constant complexifications of cultures and ways of living have to be faced and are to be preserved as a value. The project will be carried out at the University of Bologna and at the University of Oslo during a secondment period. Research outcomes will be disseminated via conferences, workshops, and scientific publications, exploited for broad policy impacts, and communicated to the larger public via multiple outreach activities. With its cross-cultural, interdisciplinary approach and via mutual theoretic reinforcement the project offers the perfect balance between research innovation, individual career development, stronger networks, and mobility between systems.

Keywords: rorty,postmodernism,poststructuralism
CIRCULAR AGRONOMICS - Efficient Carbon, Nitrogen and Phosphorus cycling in the European Agri-food System and related up- and down-stream processes to mitigate emissions (Circular Agronomics)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Austria,Germany,Italy,Germany,Spain,Spain,Italy,Spain,Belgium,Switzerland,Belgium,Czechia,Netherlands,Netherlands,Kenya
Call: Closing loops at farm and regional levels to mitigate GHG emissions and environmental contamination - focus on carbon, nitrogen and phosphorus cycling in agro-ecosystems (H2020-SFS-2017-2, 2017)
Start date: 2018-09-01
End date: 2023-02-28
Duration (months): 54.0
Total project cost (EUR): 7021764.7
EU funding (EUR): 6999795.5
Participants: 20
Project status: SIGNED

Circular Agronomics (CA) provides a comprehensive synthesis of practical solutions to improve the current Carbon (C), Nitrogen (N) and Phosphorus (P) cycling in European agro-ecosystems and related up- and down-stream processes within the value-chain of food production. The proposed solutions would constitute a further step towards making agriculture an integral part of a circular economy by increasing resource efficiency while simultaneously addressing associated environmental challenges such as greenhouse gas and ammonia emissions as well as eutrophication of water bodies. Along 7 work packages and 6 case-studies, representing locations with different biogeographic conditions and environmental challenges typical for the European agricultural sector, the objective of CA is to contribute to a development towards sustainable, resilient and inclusive economies that are part of circular and zero-waste societies. The involved multi-actor and international consortium aims (i) To increase the understanding of C, N, P flows and the related potential to reduce environmental impacts at farm and regional level under different bio-geographical conditions; (ii) To close loops within cropland farming, from livestock to cropland farming and to increase the reuse of waste/wastewater from food-industry to improve soil fertility and to increase nutrient use efficiency; (iii) To highlight the performance of different prototypes of agro-ecological systems and increase sustainability of food production in the EU; and (iv) To contribute to the improvement of the European Agricultural Policies by providing evidence based, farmer led and consumer relevant recommendations for the agri-food chain. Cross-cutting social, economic and environmental evaluation ensure the overall sustainability of the investigated solution.

Keywords: agri food chain,greenhouse gas emissions,nutrient recycling,manure,nitrate,agriculture,food waste,climate change,life cycle assessment,bioenergy,carbon management,policy briefing
Cherenkov Telescope Array: Infrastructure Development and Start of Implementation (CTA-DEV)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany
Call: Individual implementation and operation of ESFRI projects (H2020-INFRADEV-1-2015-1, 2015)
Start date: 2015-07-01
End date: 2019-12-31
Duration (months): 54.0
Total project cost (EUR): 4916562.5
EU funding (EUR): 4257813.0
Participants: 1
Project status: CLOSED

The Cherenkov Telescope Array project aims to provide a unique global facility for very high energy gamma ray astronomy addressing many long-unanswered questions in astronomy and astrophysics, astroparticle physics, particle physics, and cosmology. Two arrays of Cherenkov telescopes – one in each hemisphere – will provide unprecedented sensitivity for the study of the Universe at the highest energies of the electromagnetic spectrum. The project is supported and promoted by the CTA Consortium, with 178 institutes in 29 countries; Consortium institutes plan to provide the telescopes as in-kind contributions. CTA completed instrument specifications and design in the CTA Preparatory Phase. The ESFRI expert committee has identified the main bottlenecks towards implementation of CTA as: characterisation and survey of array sites, design and implementation of site infrastructure, concluding long-term agreements, and preparing for construction to begin. The CTA-DEV proposal targets these bottlenecks by specifically addressing: -Designing and planning in detail the site-specific infrastructure required to operate the telescopes provided by CTA Consortium institutes; -Planning the deployment process, exercising it on the first pre-production telescopes and their infrastructure, and providing a solid foundation for the mass deployment of telescopes; -Providing the legal basis for approval and deployment of CTA by creating the required founding agreement, hosting agreements, and framework contracts; -Implementing local outreach programmes in the host countries and defining the outreach infrastructure required, promoting relations with the host country at government, commercial, and public levels. These tasks will be carried out by the CTA Observatory gGmbH, a non-profit organisation founded by CTA member states to provide a legal framework for the preparations for the CTA Observatory, to administer CTA project management and system engineering, and to prepare for deployment.

Keywords: cherenkov telescope array,observatory,very high energy vhe gamma ray astronomy,site infrastructure,deployment planning,hosting agreements,local outreach
REsearch LIfecycle mAnagemeNt for Earth Science Communities and CopErnicus users in EOSC (RELIANCE)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: EOSC ecosystem
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Norway,Poland,United Kingdom
Call: Increasing the service offer of the EOSC Portal (H2020-INFRAEOSC-2020-2, 2020)
Start date: 2021-01-01
End date: 2023-06-30
Duration (months): 30.0
Total project cost (EUR): 1999972.5
EU funding (EUR): 1999972.5
Participants: 9
Project status: SIGNED

RELIANCE will extend the EOSC service offering with a set of industry-strong, innovative, interconnected services for the open, efficient, and cross-disciplinary management of the research lifecycle. In accordance with FAIR and Open Science principles, it will adopt a holistic approach to address different research activities, spanning: discovery of and access to research data, methods and materials; extraction of valuable information from scientific literature; structuring data-driven scientific investigations as semantically rich research objects; FAIR-ness self-assessment; dynamic collaboration, sharing and dissemination considering the whole lifecycle as a first-class citizen; and supporting reproducibility, validation, versioning and reuse of research results. Core to the service portfolio are Research Objects as the overarching information artefact to manage research, Data Cubes for efficient and scalable structured data access and discovery, and Text Mining for the extraction of information from scientific text as machine-readable metadata. RELIANCE will pilot the services in three different Earth Science communities, fostering the use of Copernicus data and demonstrating their efficacy in real-life vertical and multi-disciplinary scenarios, and will launch an Open Call to engage other communities. The high-TRL research-enabling services portfolio will be onboarded in ESOC following established procedures, ensuring the interplay with cross-cutting and added value services, and following a user-centric approach. RELIANCE will expose its services via APIs and libraries, enabling their use via different frontends and Jupyter notebooks. RELIANCE brings into EOSC more than 3,000 research objects from research communities like Earth Science, represented by three project partners, but also others like Astrophysics and Bioinformatics, which have embraced research objects concept and tools, and will become the best ambassadors to enlarge and engage new communities

Keywords: research lifecycle management,research objects,data cubes,text mining,earth science,fair,open science,global challenge,multi disciplinary,cross fertilisation,research publishing
Towards Intelligent DC-based hybrid Grids Optimizing the network performance (TIGON)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Italy,Spain,Italy,Spain,Spain,Spain,Finland,Bulgaria,Greece,Belgium,Greece,France,United Kingdom,Portugal
Call: DC – AC/DC hybrid grid for a modular, resilient and high RES share grid development (H2020-LC-SC3-2020-EC-ES-SCC, 2020)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 7996115.0
EU funding (EUR): 6957197.01
Participants: 17
Project status: SIGNED

DC grids attractiveness has been increased in the last years due to the high proliferation of renewable energy sources together with the increase in DC loads (electronics, LED lighting, electric vehicles, energy storage…). The main drivers behind this paradigm shift are related to the improved efficiency, flexibility, security and reliability DC grids may provide, thus increasing the sustainability of the energy distribution system. However, there is a need for demonstration of DC technologies and grid topologies so that these solutions are able to evolve from a promising solution for the future smart grids to a commercially available technological option. Under this context, TIGON aims to achieve a smooth deployment and integration of intelligent DC-based grid architectures within the current energy system while providing ancillary services to the main network. To do so, TIGON proposes a four-level approach aiming at improving 1) Reliability, 2) Resilience 3) Performance, and 4) Cost Efficiency of hybrid grids through the development of an innovative portfolio of power electronic solutions and software systems and tools focused on the efficient monitoring, control and management of DC grids. These solutions will be demonstrated in two main Demo-Sites located in France and Spain, while additional use cases in the residential and urban railway sectors will act as niche markets for analysing and further solidifying the replication of TIGON developments after the project’s end. TIGON has involved for this purpose a multidisciplinary team of 15 partners from 8 different European Member States with a well-balanced consortium integrated by 7 non-profit entities and 7 companies. This partnership provides the required expertise from fields such as power electronics, cybersecurity, standardisation, etc. to design the solutions proposed within TIGON as well as the industrial capabilities required for the manufacturing, integration and validation of the whole TIGON concept.

Keywords: mvdc grid,hybrid grid,solid state transformer,dc converter,wampac,smart energy system,cybersecurity,decission support tool
Non-contact Near Infra-Red insPEction and monitoRing For Evaluation of ComposiTes (NIR-PERFECT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2014-11-01
End date: 2015-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Increasing automation and demands for quality in production (food, pharmaceuticals, non-metals such as polymers and composite components etc.) has resulted in visual and optical inspection by humans becoming impractical in certain situations. Therefore there have been a number of non-destructive techniques developed to inspect, monitor and detect impurities and defects within products in production lines. Existing inspection tools such as X-ray imaging have been used to inspect engineering materials and food products but are subject to health and safety issues as well as large equipment footprint and high cost resulting in unsuitability for many inspection situations. Structural health monitoring (SHM) and damage detection techniques are also of great importance in the offshore, civil, mechanical and aeronautical engineering communities, both for safety reasons and because of the economic benefits that can result. The need to be able to detect damage in complex structures has led to the development of a vast range of non-destructive techniques (NDT), of which many are based upon structural vibration analysis. However, the majority of NDT systems for SHM are slow, costly and require long periods of downtime to complete. They also struggle to give structural information on near surface (<10 mm) layers. We have developed an innovative and new form of NDT, based on Near Infrared (NIR) inline inspection and detection of defects, which has been validated for non-metallic engineering materials and is capable of providing a rapid, more informative and cost effective NDT solution for composite manufacturers and end users. The NIR-PERFECT project will therefore develop a more robust business plan for this new NIR NDT inspection and monitoring system. This will then enable us to define end user specifications and allows us to align our engineering approaches to further optimise the system to meet future end user requirements.

Keywords: non destructive testing,system integration,hardware,software,composite production monitoring and inspection
Tracking the movement and dynamics of Holliday junctions (HollidayTrack)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

omologous recombination (HR) is a DNA repair pathway that plays a central role in the maintenance of genomic stability and cancer prevention. In the late stages of HR, recombination intermediates (Holliday junctions, HJs) need to be resolved to allow proper chromosome segregation. Whilst HJ processing reactions have been well characterised in vitro, there is limited knowledge of the dynamic properties of these structures within a cellular context. To explore the biological properties of HJs in vivo, I will use site-specific DNA cleavage and ChIP-sequencing techniques to reveal the distance of HJ migration from the site where HR is initiated. The ability of HJs to branch migrate spontaneously or be driven by potential HJ translocases will be determined using RAD54, BLM, WRN, RECQ1, RECQ5 and FANCM deficient cells. To enable these studies, my first challenge will be to develop a molecular tool that specifically detects HJs in vivo, that can be used to monitor the appearance and kinetics of HJs after DNA double strand break formation. The specific DNA break sites and corresponding HJ migration will be determined with respect to the dynamic chromosome domain architecture and organisation within human cells, which will provide valuable insights into the impact of local chromatin structure on HJ migration and resolution. Additionally, the newly developed HJ-specific tools may be applied to ask a wide range of questions relating to the role of HJs in telomere biology and replication fork reversal or to study patterns and distributions of HJ formation and migration in different cancer cell types.

Keywords: homologous recombination,holliday junction,branch migration,dna helicases,chromatin topology
Streptococcus dentisani's Antimicrobial Peptides: New Strategy Against Oral Diseases of Microbial Origin. (SMILES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2026-01-02
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Billions of people suffer from oral diseases world-wide while oral health treatments are not affordable for everyone. Goal 3 of the United Nations Sustainable Development challenge/priority programs, to be reached by 2030, is to promote “access to quality essential health-care services and access to safe, effective, quality and affordable essential medicines [..] for all”. The WHO points therefore towards cost-effective oral disease prevention as a key strategy to reach a universal health care access. The main scientific objective of SMILES is identifying, characterizing, and harnessing antimicrobial peptides (AMPs) produced by Streptococcus dentisani and select cocktails with biomedical application in the treatment of caries and periodontitis. S. dentisani is a probiotic bacterium which produces AMPs, and which is naturally found in oral disease-free individuals maintaining the balance for a healthy oral microbiota. Caries and periodontitis are two oral diseases resulting from microbial dysbiosis. These cocktails could be incorporated in the future as additives in conventional oral hygiene products (ex. toothpaste), as oral disease preventive agents accessible for the public independently of their monetary resources. Dr. Revilla-Guarinos has expertise in antimicrobial resistance and will lead SMILES. The research and training at the academic host institution will be complemented with an intersectoral secondment in DENTAID (an oral health care products leading company), international networking & collaborations, specialized training courses & complementary skills workshops. Dissemination & exploitation activities, as well as communication & outreach events will promote the action and its results. The overarching ambition of this action is training and preparing Dr. Revilla-Guarinos for her to start her own group in academia or, alternatively, to develop a new path by changing to a career in industry, working at the forefront of Applied Microbiology in Europe.

Keywords: antimicrobial peptides,bacteriocins,oral disease prevention,microbial dysbiosis,universal health care,cost effective,caries,periodontal disease,translational research,applied innovation
The mutation-buffering capacity of RNA chaperones (MuRChap)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The goal of this project is to investigate how mutations that affect RNA structure can be buffered in trans by RNA chaperones using a combination of experimental and computational approaches. The Warnecke lab (the host) recently showed that RNA chaperones, like their protein chaperone counterparts, can buffer the fitness effects of deleterious mutations in Escherichia coli (Rudan et al. 2015 eLife, 4:e04745). However, the rules governing mutation buffering at the RNA level remain poorly understood. Do RNA chaperones rescue misfolded RNA intermediates? Do they alleviate the effects of mutation that lead to excessively stable secondary structures? Which mutations are amenable to buffering and which are not? And does that presence of RNA chaperones render their substrate RNAs more evolvable? Here, I will evaluate the buffering capacity of a model RNA chaperone, the DEAD-box RNA helicase CYT-19, by exploring how it affects the mutational robustness of the Tetrahymena group I intron, whose self-splicing activity is dependent on its structure. Following systematic site-directed and random mutagenesis, I will assay differential splicing activity of the generated intron variants and compare results to predictions from RNA structural modelling. Importantly, I will assay activity both in the presence and in the absence of CYT-19 to identify mutations that are buffered by RNA chaperone activity. To further understand the structural impact of chaperone-dependent mutations, I will use in-cell SHAPE-Seq to determine the mutated intron structures. To my knowledge, this is the first quantitative assessment of mutational effects on RNA in the presence of an RNA chaperone. The expected outcome will improve our understanding of RNA robustness, and may reveal insights into making better RNA-based tools.

Keywords: rna chaperones,mutation buffering,intron,splicing