Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Noninvasive Manipulation of Gating in Ion Channels (noMAGIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Germany,Italy
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 2409209.0
EU funding (EUR): 1825344.0
Participants: 2
Project status: CLOSED

noMAGIC has the visionary goal of engineering genetically encoded ion channels, which can be remotely controlled (gated) by stimuli that penetrate deep into human tissue without negative side effects. The control over ion channel activity by deep penetrating stimuli will revolutionize research in neurobiology and physiology as it paves the way for remote and genuine non-invasive control of cell activity in vivo. Synthetic channels, which can be gated by magnetic fields (MF), near infrared (NIR) radiation or ultrasound (US) will be engineered in the frame of noMAGIC by three complementary work packages (WP1-3). Design and engineering of the channels will be performed in WP1 by reiterated steps of rational and irrational design, high throughput screening and in vitro and in vivo functional testing. We have identified two sensor modules for MF and NIR radiation, respectively, which will be functionally connected to a channel pore for a remote control of gating. For the US-gated channel we will engineer a channel pore that is maximally responding to local changes in the lipid environment induced by US. Design and engineering of channels will be complemented by a computational approach (WP2), which analyses, from elastic network models, the mechanical connections in the channel pore and which extracts information on the forces, which are required to gate a channel by the three stimuli. The outcome of WP2 will provide general design rules for synthetic channels with implications much beyond the present project. WP3 also contributes to the engineering effort in WP1 by a spectrum of avant-garde spectroscopic methods, which resolve structural changes of the channel proteins under the influence of remote stimuli. These structural insights will greatly advance our understanding of structure/function correlates in composite ion channels and it will inspire the design and engineering of channels, which respond to remote stimuli.

Keywords: ion channels,gating,optogenetics,k channels
integRatEd Solutions for POsitive eNergy and reSilient CitiEs (RESPONSE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Innovation actions
Countries involved: Ukraine,Spain,Italy,Spain,Spain,Germany,Belgium,Finland,Greece,Greece,Finland,Finland,Finland,Finland,Sweden,Bulgaria,Greece,Romania,Romania,Bulgaria,Finland,Sweden,France,France,France,France,France,France,France,France,France,France,France,United Kingdom,Portugal
Call: Smart Cities and Communities (H2020-LC-SC3-2020-EC-ES-SCC, 2020)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 23571459.18
EU funding (EUR): 19820169.47
Participants: 62
Project status: SIGNED

RESPONSE supports the Lighthouse cities of Dijon (FR) and Turku (FI) and their Fellow cities Brussels (BE), Zaragoza (ES), Botosani (RO), Ptolemaida (GR), Gabrovo (BU) and Severodonetsk (UA) to facilitate them deliver positive energy blocks and districts. Through RESPONSE ,the two LHs will achieve a local RES penetration of 11.2 GWh/y, energy savings of 3,090 MWh/y and an emission reduction of 9, 799 tons CO2eq/y within their districts. To achieve this goal, RESPONSE demonstrates 10 Integrated Solutions (ISs), comprising of 86 innovative elements (technologies, tools, methods), that are being monitored with specific impact metrics (KPIs). It attracts the interest of various stakeholders by generating innovative business models enabling the upscale and replication of the solutions forming a validated roadmap for sustainable cities across Europe and beyond. RESPONSE adopts an energy transition strategy, which includes 5 Transformation Axes (TAs), encompassing the 10 ISs. TA#1 focuses on transforming existing and new building stock into Energy Positive and Smart-ready. TA#2 focuses on the decarbonization of the electricity grid and the district heating/cooling systems, supporting fossil-based regions in transition and the development of energy communities. TA#3 proposes grid flexibility strategies and novel storage systems for optimizing energy flows, maximize self-consumption and reduce grid stress. TA#4 links existing CIPs with apps and other digital infrastructure to enable digitalisation of services and connected city ecosystems, integrating also smart e-Mobility to promote the decarbonisation of the mobility sector. TA#5 offers interdisciplinary citizen engagement and co-creation practices putting citizen at the forefront of shaping the cities they live in and towards the development of each city’s 2050 own bold city-vision. Special focus is given to creating resilient and safe cities increasing quality of life and lowering the impacts of climate change.

Keywords: energy positive districts,coal regions in transition,integrated solutions,transformation axes,decarbonisation,res optimisation,grid flexibility,resiliency,air quality,climate change
IoT PTO Generators for Emergency Power Supply (Schneeberger)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-10-01
End date: 2020-02-29
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Farmers and critical community infrastructure depend on constant reliable power supply. In Europe, severe weather conditions and climate change have led to a surge in power outages. These outages can have devastating consequences. For instance, if the cooling of a piglet stable lasts more than 30 minutes, the entire stock overheats and dies. Many farms and critical infrastructure personnel, as a precaution, have installed emergency power generators. These include internal combustion generators, powerpacks and PTO generators that cannot be controlled remotely. Schneeberger is a pioneer in PTO generators: it engineered the first PTO generator for the agricultural sector. and carries 21 types of PTO generators. Farmers and public services simply need to connect the PTO generators to their tractors. Our technology is so advanced that it allows for our PTO generators to be used in the field as well. We are also the only ones that have equipped PTO generators with a proprietary circuit board. We want to make PTO generators smart and up-to-date with the IoT trend. We want to develop a mobile app and an application to review the status on the computer, which allows remote control and a quick reaction time. Impending regulatory changes as well as a trend towards IoT and ever more severe weather conditions have motivated us to scale up our PTO generators to make them smart and launch them to various verticals. Traditionally, PTO generator focused on the farming sector - a potential market of 12.2 million farmers in the EU. And by offering PTO generators for additional verticals in critical infrastructure (community and municipality institutions, kindergartens, schools, etc.), we would create the non-farming PTO generator market. Our Schneeberger IoT PTO generators can contribute to a more sustainable emergency power supply, to a safer power supply, and to a wider adoption of power supply solutions in critical infrastructures.

Keywords: critical infrastructure,emergency systems,security,safety engineering
MEM’S: My Easy Moving System (MEMS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In Europe more than 600,000 people are disabled in their natural mobility but are able and need to drive since they are of employment age: we want to bring to them an innovative independent mobility solution that overcomes the limitations of the devices currently available. By using robotics-based technology, our solution will allow the disabled person to use his electric wheelchair as a driver's seat in his car, without any intervention or assistance required of third parties while getting into and out of the car, in this way fully achieving his freedom of movement. Our innovation provides the disabled with total independence, greater comfort and saving two-thirds of the equivalent average expenditure incurred today. Our solution has been designed as original equipment to be installed by carmakers, just as it can be installed in a car one already owns: it is the first sustainable standardisation solution for disabled people in the automotive sector.

Keywords: people with disability,mobility solution,special electric wheelchair
Cortical feedback in figure background segregation of odors. (COFBMIX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Israel
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-04-01
End date: 2024-03-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

A key question in neuroscience is how information is processed by sensory systems to guide behavior. Most of our knowledge about sensory processing is based on presentation of simple isolated stimuli and recording corresponding neural activity in relevant brain areas. Yet sensory stimuli in real life are never isolated and typically not simple. How the brain processes complex stimuli, simultaneously arising from multiple objects is unknown. Our daily experience (as well as well-controlled experiments) shows that only parts of a complex sensory scene can be perceived - we cannot listen to more than one speaker in a party. Importantly, one can easily choose what is important and should be processed and what can be ignored as background. These observations lead to the prevalent hypothesis that feedback projections from ‘higher’ brain areas to more peripheral sensory areas are involved in processing of complex stimuli. However experimental analysis of signals conveyed by feedback projections in behaving animals is scarce. The nature of these signals and how they relate to behavior is unknown. Here I propose a cutting edge approach to directly record feedback signals in the olfactory system of behaving mice. We will use chronically implanted electrodes to record the modulation of olfactory bulb (OB) principal neurons by task related context. Additionally, we will record from piriform cortical (PC) neurons that project back to the OB. These will be tagged with channelrhodopsin-2 and identified by light sensitivity. Finally, we will express the spectrally distinct Ca++ indicators GCaMP6 and RCaMP2 in PC neurons and in olfactory sensory neurons, respectively, and use 2-photon microscopy to analyze the spatio-temporal relationship between feedforward and feedback inputs in the OB. This comprehensive approach will provide an explanation of how feedforward and feedback inputs are integrated to process complex stimuli.

Keywords: olfaction,figure background segregation,attention
Nano Traction (Nano Traction)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

In this Marie Skłodowska-Curie Fellowship project entitled “Nano Traction” I will design a platform for the directed autonomous movement of nano- and microparticles. This will be achieved using a completely novel form of traction based on the dynamic covalent attachment of the particles to a surface. Asymmetrically applied redox potentials will induce motion allowing the electrical control of nano- and microparticle motion and the creation of particles that autonomously move and seek out cells that are producing reactive oxygen species a key indicator of disease. This Fellowship will be undertaken under the supervision of Prof. Molly Stevens in the Division of Biomaterials and Regenerative Medicine at the Karolinska Institute (KI), which has the world-leading expertise in functional nanomaterial synthesis, biomaterials engineering, cell biology and tissue engineering crucial to the objectives of this proposal. This ground-breaking new method of particle control at micro and nanometre length scales will have application in many areas including; precision actuation for nanorobotics and microfluidics and; the creation of cell seeking particles for biosensing and the targeted delivery of nanoparticle agents. It will not only initiate new research areas at the cutting edge of nano- and biomaterials science, but will help me to establish my own independent research career following the proposed Fellowship.
Development of a durable and energy-efficient baking plate (Thermoback)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Germany
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In average Europeans consume 650kg of bread per person per year. To answer the increasing demand in term of variety and quality, both industrial and craft bakers need to improve qualitative, economic and energetic process efficiency. The current baking plates in the ovens are made from concrete and are energetic inefficient, having a low life expectancy and reduce the quality of the products. Conrad Liphard & Söhne has developed a new and innovative baking plate from ceramic with outstanding baking characteristics, Thermoback. This development has demonstrated energy-efficient, durable, and heat conduction improvement. The plate is made of a mixture of calcium oxide, aluminum oxide, as well as various additives as silicon carbide which helps to reach optimal heating values. Thermoback demonstrated: about 30% of energy savings, high stability of the plates (firm, unbreakable plates), time savings up to 25%, and a higher product quality. Liphard & Söhne wants to introduce thermoback technology into the market, and therefore, with the requested fund, a feasibility study as well as a market research will facilitate the product’s entry.

Keywords: energy efficient,long life expectancy,bakery sector,bread consumption,baking plate,heat conduction improvement,save time,feasibility study,market exploitation
Ultrafast Demagnetization Dynamics Using Novel Table-top X-ray Source (FASTMAGNETS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Magnetic data storage enabled the tremendous progress in the modern computing and the amount of data world-wide is progressively growing. The continuing growth relies on the technological innovations as well as research in the fundamental magnetic interactions. With the growing amount of data being recorded/erased on the magnetic memory devices, it poses a question of what are the fundamental speed limits for altering the magnetization state and what are the underlying mechanisms of the interaction. One of the most intriguing questions in the field of ultrafast magnetism is what is the fundamental speed limit for demagnetization (“erasing”) or magnetization switching (“writing”). In this proposal the applicant proposes the use of novel state-of-the soft X-Ray sources based on high order harmonic generation (HHG) to study magnetization dynamics in ferromagnetic materials on the unprecedented temporal resolution. The aim of this project is to address three fundamental questions in the field of ultrafast magnetization dynamics: (1) how fast can a magnetic sample be demagnetized when heated by an ultrashort laser pulse? (2) how fast can the magnetization component of a device be switched by an oscillating electromagnetic field? (3) what is the mechanism behind the ultrafast laser-induced demagnetization? These three work packages will be performed at University of Geneva together the support from thee partner institutions: INRS-EMT in Canada, and two groups in ETH Zurich. These results will lead to a major breakthrough in ultrafast magnetism research field and represent the long-standing goals actively pursued by many laboratories around the world. These experiments will provide an insight into the physics, the ultimate speed limits of such ultrafast magnetization switching, and will contribute to the development of fast memory storage devices in the future.

Keywords: ultrafast magnetism,femtosecond,x ray,high order harmonic generation
An Integrated Security Concept for Drone Operations (SECOPS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Finland,Belgium,Netherlands,Netherlands
Call: Security & cyber-resilience (H2020-SESAR-2016-1, 2016)
Start date: 2017-10-01
End date: 2019-12-31
Duration (months): 27.0
Total project cost (EUR): 909293.75
EU funding (EUR): 909293.75
Participants: 4
Project status: CLOSED

Project SECOPS (an integrated SECurity concept for drone OPerationS) is initiated by a research centre (NLR) and 3 SME industrial partners (SensoFusion, Unifly and Delft Dynamics), in response to the SESAR2020 Remotely Piloted Aircraft Systems (RPAS) Exploratory Research Call, under Topic 06 “Security & cyber-resilience”. SECOPS' objective is to push drone technology forward by ensuring that security risks in the Unmanned Traffic Management (UTM) concept are mitigated to an acceptable level. An integrated security concept at TRL2 will be developed addressing resistance of drones against unlawful interference, protection of third parties and integration of geo-fencing technology; focussing on technological options (navigation, surveillance, in-flight updates, etc.) for both airborne and ground elements, considering legal, regulatory and social aspects. SECOPS will include a proof of concept of the integrated security concept, integrating COTS technology of the consortium partners. A preliminary demonstrator, based on a realistic scenario, will be performed at the Netherlands RPAS Test Centre (NRTC). The comprehensive experience of the SECOPS partners working on drone security and geo-fencing in various R&T projects and initiatives, joint national and European collaboration on multiple aerospace programs of OEMs motivate their common application. NLR has a strong track record in drone research, testing, applications and training. The industrial partners are keys to the project’s success: SensoFusion in the development and commercialisation of the AIRFENCE drone detection and prevention system, Unifly in the development of a UTM system and Delft Dynamics in developing and building robot helicopter systems to provide innovative security solutions for drone and third parties, but also in the development of the counter drone system DroneCatcher. SECOPS total grant request to EC is 909 293€ for the whole consortium and the project will be conducted within 24 months.

Keywords: rpas operations,security and cyber resilience,drone security,geo fencing,datalink security,rpas testing,airspace integration,dynamic geo fencing