Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
INTERNATIONAL HUMAN EXPOSOME NETWORK PROJECT (IHEN PROJECT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: Coordination and support actions
Countries involved: Spain,Netherlands,Czechia,France,Cyprus,Finland,Belgium,Greece,Lebanon
Call: Global coordination of exposome research (HORIZON-HLTH-2023-ENVHLTH-02, 2023)
Start date: 2023-12-01
End date: 2026-11-30
Duration (months): 36.0
Total project cost (EUR): 2999957.5
EU funding (EUR): 2999957.5
Participants: 12
Project status: SIGNED

The proliferation of exposome research programs and projects has led to a significant increase in research output and to the establishment of new initiatives and infrastructures in Europe and globally. Yet, cooperation between initiatives at the EU level and globally is still sporadic and scattered. The IHEN Project aims to establish an International Human Exposome Network (IHEN) with the overall purpose of improving global research and cooperation on the exposome. It proposes an ambitious pathway towards the development of a longer term IHEN that brings together multi-sectorial stakeholders globally, which is essential for enhancing the impact of future exposome research. Specific objectives are to: 1) design the organisational structure of IHEN so that it serves to strengthen cooperation and coordination of exposome research in Europe and foster and align cooperation globally, including options for long-term governance and financing; 2) identify and make available exposome tools, metadata and resources at the global scale in a FAIR toolbox, including tool inventories and data catalogues; 3) test the FAIR toolbox via a series of demonstrator projects; 4) develop a roadmap for future exposome research and innovation, including the formulation of an operational definition of exposome research and an interim research agenda; and 5) effectively communicate and disseminate the IHEN Project results to a wide community of stakeholders, and develop an inventory of exposome training opportunities. The project will interact, in all stages of the work, with key stakeholders’ groups: EU and global exposome researchers, initiatives and infrastructures; EU, national, and international agencies and organisations; funding bodies; civil society organisations; and industry.

Keywords: exposome,international network
COx-free Hydrogen Production in Additively Manufactured Electrified Reactor through Catalytic Decomposition of Ammonia (CHyAMera)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Slovenia,Austria
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 155559.36
EU funding (EUR): 155559.36
Participants: 4
Project status: CLOSED

Europe’s transition to a decarbonised energy system, as outlined in the EU Green Deal, will radically transform how the EU generates, distributes, stores, and consumes energy. It will require virtually carbon-free power generation, increased energy efficiency, and the deep decarbonisation of transport, buildings, and industry. Europe is further boosting its green hydrogen ambitions to secure energy independence following the global geopolitical tensions and market instability. The current need to decarbonise our economy makes the search of new methods crucial to use chemicals, such as ammonia, that can be produced and employed as carbon-free (COx) hydrogen carrier. Dr. Milan Vukšić (applicant) will design and additively manufacture a modular, monolithic, multiscale ceramic catalytic reactor for magnetically heated COx-free hydrogen production with the fully electrified decomposition of ammonia. The project will be carried out at the Institute Jozef Stefan and the National Institute of Chemistry, Slovenia, under the supervision of Dr. Aljaž Iveković, Prof. Andraž Kocjan, and Prof. Blaž Likozar as consequence of a high level of interdisciplinary work. In contrast to the established stereolithography process, where ceramic filler particles are bound by a polymeric binder, the proposed project aims to form polymer-derived ceramic (PDC) structures by photopolymerisation of pre-ceramic polymers (PCPs) followed an additional heat treatment (pyrolysis) in collaboration with the TU Wien, supervised by Prof. Thomas Konegger. The main research focus will be on the additive manufacturing of ceramic catalytic reactor components with magnetic functionality induced by the in-situ formation of magnetic nanoparticles. The final goal of the project is to demonstrate the viability and advantages of the proposed approach for technical innovations and improvements in end systems that can use ammonia fuel.
Innate lymphoid cells and tissue adaptation to changing metabolic needs (ILCADAPT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 2379266.0
EU funding (EUR): 2379266.0
Participants: 1
Project status: SIGNED

Border surfaces of vertebrate organisms are in constant exchange with their habitat. Host cell networks consisting of epithelial cells, stroma and tissue-resident immune cells continuously integrate signals from the environment, a process by which an organism becomes better suited to its habitat (i.e., adaptation). Our understanding of the molecular underpinnings of such homeostatic processes is in its infancy, yet they are decisive for proper organ function. Recently, we and others have identified homeostatic circuitry involving tissue-resident immune cells in the small intestine facilitating adaptation to changes in nutrient cargo. The goal of my laboratory is to capture these molecular networks and to investigate how their failure predisposes to diseases. This proposal aims to systematically define the role of mucosa-associated group 3 innate lymphoid cells (ILC3) and of the IL-22:IL-22BP module in tissue adaptation to changes in metabolic need via their interaction with intestinal stem cells, stromal cells and enteroendocrine cells (EEC). Answering these questions demands both focused and global experimental approaches as well as the use of new genetic models for targeting of ILC3 and for recording epithelial cell differentiation. Based on these considerations and on strong preliminary data, we have devised 3 Specific Aims that will allow an unprecedented analysis of ILC3-controlled tissue adaptation: (1) to understand intestinal ILC3-epithelial cell units regulating nutrient handling and systemic metabolism, (2) to test the role of ILC3 in intestinal adaptation to increased metabolic demand during pregnancy, and (3) to characterize a new immune-epithelial module consisting of EEC and IL-22-producing ILC3. We and others have demonstrated that ILC3 effector programs are highly conserved and are operative in humans. Thus, the anticipated results will carry tremendous implications for the prevention and therapy of metabolic diseases.

Keywords: innate lymphoid cells,interleukin 22,ilc epithelial cell units
Construction of a FLEXIble and adaptable enZYMatic biotechnological platform for sustainablE industrial production of bio-based fatty amines from side stream materials (FLEXIZYME)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Research and Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Spain,Greece,Netherlands,Italy,France,Belgium
Call: Robust and optimised industrial biotech and chemical/industrial biotech processes (HORIZON-JU-CBE-2023, 2023)
Start date: 2024-06-01
End date: 2028-05-31
Duration (months): 48.0
Total project cost (EUR): 4984163.75
EU funding (EUR): 4984163.75
Participants: 19
Project status: SIGNED

Fatty amines possess cationic and surface-active properties, finding applications in cosmetics, coatings, detergents, and more with a projected market growth to $5.54 billion by 2027. The traditional "nitrile route" for their synthesis is flawed by drawbacks like high energy needs, toxic catalysts, harsh conditions, and low selectivity, resulting in complex amine mixtures. Biotechnological alternatives, deploying enzymes, offer a sustainable alternative, characterized by mild conditions and high selectivity but their industrial implementation is hampered by cost and complexity challenges. Currently, there's a lack of a holistic approach that considers upstream, midstream, and downstream factors when designing biotechnological processes. FLEXIZYME aims to pioneer an interdisciplinary, systematic biotechnological platform for fatty amine production from fat and protein-rich residues, encompassing all process stages. Integrating cutting-edge technologies will address limitations hindering enzyme use in cosmetics, detergents, and agriculture. Scaling up and validation across these sectors is a pivotal project aspect. Key project elements include a chemo/enzymatic approach, enzyme engineering/improvement, machine learning tools applied to experimental and in silico data, reactor design and monitoring. These findings will culminate in a biotechnological platform for fatty amine production, encouraging widespread adoption of biotechnological industrial applications. Guided by Techno-Economic Assessment and Life Cycle Assessment, FLEXIZYME ensures productivity, yield, robustness, and flexibility. A multi-actor approach and interdisciplinary collaboration aligned with industrial needs will streamline the implementation of the biotechnological platform's outputs in industry. This flexible, versatile biotechnological platform marks an innovative departure from existing fatty amine production processes, addressing current limitations enhancing environmental performance.

Keywords: green chemistry,bio products,ia,enzyme engineering,process design,reactor design,circular economy
Beyond state of the art Efficiency by improving Balance of Plant components (BeBoP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Norway,Germany,France,Italy,Switzerland
Call: Balance of plant components, architectures and operation strategies for improved PEMFC system efficiency and lifetime (HORIZON-JTI-CLEANH2-2024, 2024)
Start date: 2025-01-01
End date: 2028-06-30
Duration (months): 42.0
Total project cost (EUR): 5017882.73
EU funding (EUR): 3983049.07
Participants: 8
Project status: SIGNED

The BeBoP project will achieve an overall increase in system efficiency and durability and a reduction in Total Cost of Ownership (TCO) of fuel cell systems for heavy duty applications by providing for and incorporating improvements in key balance of plant (BoP) components - air compression and humidification, and DC-DC conversion. Novel and integrated cell monitoring combined with advanced modelling will lead to overall architectural- and operational optimizations. The project brings together key component developers already actively supplying BoP components into the market (Garrett, Freudenberg and Silver Atena), with the specialist powertrain division of a heavy-duty truck manufacturer IVECO (FPT), alongside two leading European research institutes (SINTEF and DLR) with a strong records in the area of fuel cell systems development and modelling. Novel key BoP components (air compressor, humidifier and DC/DC converter) will be developed from the current status of TRL 3 to TRL 5. The prototype components will be tested to prove performance, either on a fuel cell engine (for the air compressor and DC/DC converter), or at a test bench (humidifier), and iteratively modelled and improved with real time data. Collectively, the developments will bring about a significant optimization of both BoP and system level characteristics, addressing performance, durability and cost targets. Beyond this, next generation fuel cell systems and their scalability will be explored through modelling, involving improved compressor configurations and stack operation on enriched air to further increase system efficiency and validate the applicability to other heavy-duty segments of transport. Through collaboration with its Advisory board, which comprises University of Groningen, Ballard, EKPO, IVECO, Damen, Seam, Isotta Fraschini, ZeroAvia and Lufthansa Technik, and the ScaBoP project, which is exploring the scale up of BoP components, this project will facilitate a strategic alliance and contribute to achieving the project's objectives.

Keywords: balance of plant,fuel cell
Multidimensional Integrated Quantitative Approach To Assess Safety And Sustainability Of Nanomaterials In Real Case Life Cycle Scenarios Using Nanospecific Impact Categories (INTEGRANO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Italy,Belgium,Portugal,Spain,Israel,Bulgaria,Denmark,Germany
Call: Integrated approach for impact assessment of safe and sustainable chemicals and materials (RIA) (HORIZON-CL4-2023-RESILIENCE-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 4140133.35
EU funding (EUR): 3985648.75
Participants: 13
Project status: SIGNED

In line with the current guidelines for Safe and Sustainable by Design (SSbD) chemicals and materials, INTEGRANO proposes a general assessment approach based on quantitative evidence to be applied in practice for specific Nano Materials (NMs) design cases referred to inorganic, organic and carbon NMs. The development NMs dedicated novel impact categories (ICs) for nano-toxicity and eco-nano-toxicity assessment will enable the integrated application of standardised assessment methodologies. The following four NMs Life Cycle Stages (LCS) are addressed: synthesis, incorporation, use phase and end-of-life. The application of the stage-gate SSbD process through the LCS addresses performance in the five dimensions (5D s): Safety, Environmental, Economic, Social and Functional. Generation of dedicated response functions will allow associating Key Decision Factors (KDFs, such as: concentrations, processing parameters, etc.) to Key Performance Indicators (KPIs, such as: occupational safety, CO2 emissions, job creation potential, NM cost, antibacterial functionality, etc.). SSbD NMs solutions will be obtained by Multi Objective Optimisation Design (MOOD) dedicated algorithm. A dedicated digital Decision Support Toolbox (DST) will elaborate design case specific data and run MOOD algorithm to sort the set of multi-optimal SSbD options, which are simultaneously complying with all the targeted KPIs referred to the 5Ds. The digital supported decision process will help scientists, material engineers, Nano-Enabled Products (NEPs) designers, policymakers and decision-makers to takle the SSbD challenge, allowing for dramatic reduction of Research & Development (RTD) and approval lead-time as well as minimising costs and increasing the transparency of the data, by making the industrial uptake of nanotechnologies more sustainable and viable. INTEGRANO allows the integration with other existing SSbD frameworks by transposing results into other scoring metrics and enabling data exchange.

Keywords: multioptimization analysis,life cycle stages,lead time reduction,design of experiment,open platform,
Site-selective C(sp3)–H functionalization with gaseous reagents using Hydrogen Atom Transfer photocatalysis in flow (FlowHAT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

An essential part of synthetic organic chemistry is the conversion of raw materials into highly complex molecules. While traditionally this has been achieved through conversion of functional groups, Nature has developed strategies to deliberately functionalize C–H bonds in organic molecules. Mimicking Nature’s machinery, chemists have developed a diverse set of powerful C–H bond functionalization strategies. However, undirected and selective C–H bond functionalization is still very challenging and it remains “a dream reaction” for the community. Herein, I propose a novel approach that combines both chemical and technological tools and is based on a continuous-flow photocatalytic Hydrogen Atom Transfer (HAT) that uses cheap decatungstate to activate these C(sp3)–H bonds selectively. Four different reaction classes will be developed which forge C=O, C–NO, C–SO2X and C–CO2H bonds using respectively O2, NO, SO2 and CO2 as cheap and atom-efficient reagents. All these methods provide useful functional handles which can be seamlessly engaged in other transformations. I will show that our methodology can be used to enable the late-stage diversification of bioactive molecules, establishing a new way of retrosynthetic thinking. Furthermore, I propose to exploit the intrinsic ability of HAT to abstract a hydrogen from volatile alkanes, such as methane, to generate the corresponding carbon-centered radicals. These nucleophilic radicals will be engaged in various cross-coupling transformations, including enantioselective variants. Moreover, I envision that a combination of continuous-flow, automation technology and machine learning will provide a much-needed technological impact, enabling the development of unique screening tools for the reproducible functionalization of organic molecules. The synthetic methods and technological tools will provide a breakthrough in the selective functionalization of strong C(sp3)–H bonds in both gaseous alkanes and biologically active molecules.

Keywords: flow chemistry photocatalysis synthetic methodology microreactor gas liquid reaction
Interfacial Electrochemistry of Carbon-based Interlayer in Lithium-metal Solid-state Batteries (IECILSB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: CLOSED

Lithium-metal solid-state batteries (LMSSBs) are regarded as highly promising Post-Lithium-Ion Technology due to their high energy density and exceptional safety. However, their practical application remains challenging because of the interfacial issues at the metallic lithium|solid-state electrolyte interface (e.g., contact resistance and dendrite formation). In this regard, interlayer engineering based on carbon materials with different dimensions and fluorination degrees has been proposed to effectively address interfacial issues. Specifically, carbon quantum dots (0D), nanostripes (1D), and nanosheets (2D) will be used to clarify the influence of the geometric structure of carbon on the plating/stripping performance of lithium ions. Also, the fluorination degrees of carbon nanostructures will be precisely regulated to quantitively understand the fluorine chemistry-electrochemical performance relationships. Ultimately, this project will fill the knowledge gap in geometric design and chemical modification of carbon-based interlayer materials for developing safety LMSSBs with energy density > 500 Wh kg-1 and cycling life > 2000 times.

Keywords: interface,carbon interlayer dendrite lithium metal sold state batteries
MWGaiaDN: Revealing the Milky Way with Gaia (MWGaiaDN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands,Japan,South Africa,United States,Spain,Portugal,Ireland,United Kingdom,Italy,France,Sweden,Germany,Greece
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-02-01
End date: 2027-01-31
Duration (months): 48.0
Total project cost (EUR): 2618733.6
EU funding (EUR): 2618733.6
Participants: 23
Project status: SIGNED

The Milky Way-Gaia Doctoral Network (MWGaiaDN): Revealing the Milky Way (MW) with Gaia - Excellent science, Extending techniques, Enhancing people skills, Effecting the next revolution in European led astronomy through leadership in astrometric-based science. What: Gaia, ESA’s major space mission launched in Dec 2013, is now in its extended mission to map some two billion stars in the MW. It’s upcoming data releases , that will provide chemical and physical annotation of the earlier positional releases, present major challenges in terms of complexity and size, hence research training to deliver a full science exploitation is essential, ensuring that Gaia is the `game changer’ for astronomy How: Our DN will link major partners responsible for the development of Gaia, to form an effective and unique training network combining the best research training with a range of academic and industrial placements, specialist research and knowledge transfer workshops. It will develop and train a cohort of young researchers through a set of key science projects pushing the Gaia data to its limits. Our DN will train 10 ESRs located across 10 European beneficiaries, benefiting from the participation of 13 associate partners. These include major industry (e.g. AirbusDS, TAS), at the forefront of Space and Information technologies; SME Industry (e.g. DAPCOM, Suil), innovating new technologies for Space and partners leading the development of next generation astrometry missions outside of Europe (NAOJ). Relevance: It will shape the delivery of training in astrometry and the study of the MW across Europe: delivering key insights into the structure and formation of our Galaxy; delivering the roadmap for the next generation of astrometric space telescopes; equipping the ESRs with skills to drive the next innovative steps in this crucial area of space discovery, as well as enabling them to contribute to the future, growth and challenges of the big data industry and commerce. MWGaiaDN

Keywords: astrometry,data intensive astronomy,astro statistics