Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Phthalocyanine-biopolymeric nanoparticle delivery systems for cancer photodynamic therapy (BIOnanoPDT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Poland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-02
End date: 2024-02-27
Duration (months): 24.0
Total project cost (EUR): 149625.6
EU funding (EUR): 149625.6
Participants: 1
Project status: SIGNED

According to the World Health Organization cancer was responsible for approximated 9.6 million deaths in 2018 what is the reason of being one of the biggest civilizational health problem, just behind the heart diseases. The global objective of interdisciplinary BIOnanoPDT project is to develop novel biodegradable phthalocyanine (Pc)-polymeric nanoparticles (NPs) which enhance cancer photodynamic therapy (PDT). Up to now, there is no ideal therapy for cancer treatment but among the others PDT presents several advantages, e.g. it is a selective treatment with less secondary effects than other therapies. This promising therapy combines three components: photosensitizer (PS), light and oxygen. 20 years ago PDT was approved by Food and Drug Admnistration as a clinical protocol for cancer treatment but it still have limitations to use it in all types of cancer. The development of new powerful PSs, which specifically target cancer cells, and can more deeply penetrate tissue allowing to treat large tumors is still a challenge. Phthalocyanines (Pcs) are one of the most promising second generation PSs and meet many requirements for being ideal PSs. Unfortunately, very often Pcs are hydrophobic species and undergo self-aggregation in aqueous solutions, which drastically reduces their photosensitizing efficiency. In BIOnanoPDT project the limitations of Pcs will be overcame by tailoring their properties in terms of singlet oxygen generation and by incorporating them with polymer NPs which could improve their photophysical properties, selectivity for targeted tissues by surface modification, eliminate aggregation of the PSs and their low water solubility. Additionally, it can enhance the treatment by increasing the blood circulation and selective accumulation in tumor cells. The BIOnanoPDT project will bring many innovations to the current cancer research by novel Pc-polymer NP hybrids for cancer PDT which will be an attractive alternative for conventional drugs.

Keywords: polymeric nanoparticles,phthalocyanines,breast cancer,photodynamic therapy
Fiction Film and Borderlands (REEL BORDERS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1482562.0
EU funding (EUR): 1482562.0
Participants: 1
Project status: SIGNED

REEL BORDERS aims to bring fiction film to the centre of discussions about borders and belonging. As different institutions and actors increasingly turn to fiction film to circulate messages about borders, the study looks at how borders and fiction film have been related since the early 20th century. Border regimes are intimately intertwined with cultural imaginations and representations of borders and their insiders and outsiders. This project is the first to comprehensively investigate this relation across different borderlands and for the various actors involved. While grounded in the cultural studies tradition, it originally combines insights from representations research, film theory, popular geopolitics, border studies and migration studies. The main questions to be addressed are: What are the cultural imaginations of borders and its insiders and outsiders found in fiction film? How do different societal actors use fiction film to construct, contest, or experience territorial borders? These questions will be answered by looking at 3 groups of actors (institutions, creatives, and borderlanders) at 3 borderland cases: Ireland-UK, Turkey-Syria, and the Ceuta and Melilla exclaves. The study will combine archival work with media studies methods (production, content and reception analysis) and participatory filmmaking where borderlanders will make their own short films. REEL BORDERS will have a threefold impact. Empirically, it puts film firmly on the map of research on borders, conflict and migration, while expanding the horizon both in terms of historical depth and geographical width. Methodologically, it will include the most ambitious participatory film study to date. Theoretically, the study will establish new conceptual understandings of borders and belonging in cultural studies and beyond.

Keywords: popular geopolitics,border studies,participatory visual methods,film,media and migration
A novel technology enabling efficient delivery of personalized probiotics to prevent gut-related diseases and recover damaged gut microbiota (MBSelect)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-06-01
End date: 2022-11-30
Duration (months): 30.0
Total project cost (EUR): 2875932.0
EU funding (EUR): 1995700.0
Participants: 1
Project status: CLOSED

Gut-microbiome is an essential part of human health. Gut bacteria imbalance is now recognized as a crucial factor in the development of many diseases – chronic, obesity, diabetes, liver, cardio, cancer and neurodegenerative. Traditional probiotics used today, aimed at restoring this imbalance, are not effective: They are incapable of delivering sufficient number and variety of bacteria to the correct location in the gut and have them colonize. MyBiotics, a microbiome company, developed a novel technology for very efficient growth, delivery, and colonization of needed bacteria types in the gut. The technology uses innovative fermentation methods to grow complex bacteria communities on micro-particles, dry it to powder and place into capsules administered like any probiotic supplement. MyBiotics proved the technology for single-strain-bacteria and for replicating multi-strain biological samples. In this project it is introducing MBSelect, which will remove the reliance on a biological sample and add formulation of multi-strain communities of human bacteria, grown in pre-selected clusters in any combination. The MBSelect innovation enables, for the first time, the creation of personalized, microbiome-based probiotics, fitted to any purpose – recovery from illness, chronic condition, or as supplements – and fitted to specific microbiome needs of different ethnicities, age, and gender. MyBiotics won and executed a Phase1 feasibility study in 2015, which served as a basis for its development since and for this project application. MyBiotics’ objectives in this project are to complete the development of the MBSelect technology, develop its first three probiotic products, scale them to industrial level, test them, and produce the 1st batch for initial commercial market testing immediately following the project; followed by full EU & US commercialization and scaling. The success of MBSelect is key in realizing the potential of MyBiotics and enabling the company to grow.

Keywords: microbiome,dysbiosis,probiotics,pharmaceutical,medical,chronic disease,bacteria,dietary supplement,food supplement,healthcare,microbiology,antibiotics,personalized medicine
Plasma active pollution control system (PAIR)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Innovative active air pollution control system based on plasma technology.

Keywords: ammonia,odour,plasma
How our adaptive immune system separates “self” from “foreign” – a physicochemical study of binding in cell contacts (SELFOR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

How can our immune system efficiently fight foreign pathogens at the same time as it is selective enough to leave our own cells alone? This, so called antigen discrimination, is still not understood on a molecular level. I will here illuminate this question by developing a physicochemical understanding of how T-cell receptors (TCRs) bind peptide-loaded major histocompatibility complexes (pMHCs), and importantly, how this differs for pMHC displaying self and foreign peptides. The interaction between TCRs and pMHCs on contacting immune cells is the first step in initiating an adaptive immune response. However, binding between membrane-anchored TCR and pMHC is a challenging physicochemical problem that has not been solved, and the binding kinetics is strongly affected by the membrane. Well-controlled measurements between TCR and pMHC under relevant conditions are needed to better understand the TCR/pMHC kinetics. A key discovery to achieve this is a method recently developed by me, which allows for extremely weak protein-protein interactions in contacting cells to be measured. I will in this project, backed up by immunologist in Oxford and theoretical chemists in Lund, build on this breakthrough and for the first time measure the binding kinetics between TCR in model cell membranes and pMHC on single cells, and how binding varies between self and foreign pMHC. Parameters such as adhesion molecules, applied force on the bond, the co-receptor CD4 and TCR clustering are all crucial for proper T-cell signalling, but their influence on the TCR/pMHC binding kinetics is unknown, and will here be studied. The obtained data will finally be used to evaluate, and improve on, kinetic models of antigen discrimination. Complemented with molecular dynamics simulations this altogether opens up for a fundamental understanding of binding between membrane-anchored molecules in general, and how this affects the TCR/pMHC interaction and antigen discrimination in particular.

Keywords: intermolecular interactions,binding kinetics,adhesion,supported lipid bilayers,theoretical models
Optical Sensor System for Realtime Proprotor Flapping Angle Monitoring (FLAPSENSE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Germany,Netherlands
Call: Contactless measurement system for real time monitoring of proprotor flapping angle (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2023-12-31
Duration (months): 70.0
Total project cost (EUR): 925720.51
EU funding (EUR): 872422.89
Participants: 3
Project status: SIGNED

The main objective of the proposed project FLAPSENSE is to design and manufacture a contactless measurement system for real time monitoring of proprotor flapping angle. The system will be integrated in the proprotor assembly and co-rotates with the rotor. It will be based on an highly accurate optical sensing method providing the actual flap motion of the rotor blade to the avionic system. The Partners DLR, Hit09 and NLR will closely cooperate in order to design and manufacture a sensor prototype during the project duration. Furthermore the function of the prototype will be demonstrated during a test bench experiment. Besides this demonstration test the development process for the airworthy sensor system will be completed until the CDR in order to pace the way forward for a sensor system for the NextGenCTR Demonstrator.

Keywords: rotating camera,marker detection,realtime measurements,rotor flapping
Virtual Reality in high fidelity Flight Simulation (VR-FS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Türkiye
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-07-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The adoption of flight simulation slowly started after the Second World War, as a disruptive innovation in the training of aviation pilots. Its enormous potential for cost savings was the driving force for its progressive adoption. Currently, the cost of a training session in a Full Flight Simulator (FFS) is estimated to be between 5-20% of the cost of a session in a real aircraft. High fidelity (HI-FI) flight models are the core of Full Flight Simulators, as models replicate the aerodynamics that rule how aircraft fly and how they react to flight control inputs and to external physical conditions (turbulence, wind, precipitation, ...). These models represent “only” 5% of the total cost of a FFS, which is in the average of €25 million, since the hardware equipment comprises very complex motion platforms (required for 6-degree of freedom, in order to emulate movements and acceleration of a real aircraft) and aircraft cockpits (specific for each aircraft model, replicating the real instrumentation panel and flight controls) mounted on the platform. Our solution is the integration of HI-FI Flight Models in Virtual Reality (VR), creating a VR FFS that eliminates the high costs related to hardware in the current FFS, lowering the price of FFS from €25M to €125K. During the 5 months of execution of Phase 1 we will validate the technical, operational and financial viability of our solution.

Keywords: flight simulation,aviation,virtual reality,flight training,simulator
Aerial Transport for Remote Areas (ATRA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2020-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Shipping to and from remote locations is costly and challenging. In the Alps (Europe) there are plenty of mountain shelters that cannot be accessed with vehicles. Those mountain shelters depend on the expensive and inefficient transport service of helicopter companies. FlyingBasket offers aerial transport services for medium payloads of up to 100 kg. This service will be offered in combination with our innovative multicopter (UAV), called FB3 capable of lifting payloads of up to 100kg. Our multicopter will use a pure electric propulsion system and batteries for energy storage. An aircraft like this is a compelling goal due to low noise, no exhaust gases, and battery energy transformed to motive power exceeding 80% efficiency. Founded by Moritz and Matthias Moroder in 2015, FlyingBasket has the necessary expertise to carry out the Phase 1 Feasibility Study. Our young team holds complementary competences in the technical field and in project management. We plan on hiring additional skills for production, development and marketing activities, growing to 95 employees by 2025. The Feasibility Study will be used to acquire a deep understanding of the market, competitors, customer segments, end-users and stakeholders, the company plans to reach TRL9 through the SMEI-2 by 2021.

Keywords: multicopter,delivery service,remote areas delivery
Origin and evolution of organic matter in carbonaceous chondrites: influence of hydrothermal processes (HYDROMA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-09-01
End date: 2025-02-28
Duration (months): 66.0
Total project cost (EUR): 1994351.0
EU funding (EUR): 1994351.0
Participants: 1
Project status: SIGNED

Carbonaceous chondrites (CC) are believed to be fragments of carbonaceous asteroids from the asteroidal belt. They contain up to 4wt% of organic compounds, showing a huge diversity and extremely variable H and N isotope compositions. These isotope compositions can relate to synthesis environments but the exact nature of the processes that influenced the formation of organic compounds in CC remains unresolved. Part of the issue comes from the occurrence of hydrothermal alteration on the chondrites that exhibit the largest content in organic matter. Hydrothermalism may have modified the chemical and isotopic signature of organic molecules, but the extent of these modifications is not yet constrained, leaving a lot of uncertainties on the interpretation of H and N isotope ratios. The HYDROMA project aims at determining the effects of hydrothermalism on the D/H and 15N/14N ratios of organic molecules in CC. This project will rely on an innovative experimental approach to quantify isotopic exchange of hydrogen and nitrogen between organic compounds and the hydrothermal fluid. HYDROMA will provide a self-consistent determination of the extent and kinetics of the modification of the isotopic signatures recorded in organic molecules. Hence, it will improve the understanding of H and N-isotope systematics of organic matter in CC. HYDROMA will permit using isotope composition of organic compounds to constrain the hydrothermal events (duration, temperature) on carbonaceous asteroids. This multidisciplinary research will shed new light on the origin and reprocessing of organic matter in the early solar system, and its delivery to rocky planets, including the Earth, thus disclosing the origin of prebiotic molecules on our planet.

Keywords: organic matter,carbonaceous chondrites,isotope fractionation,hydrothermalism,h isotopes,n isotopes,compound specific mass spectrometry,asteroids,protoplanetary disk
Twinning for Sustainable and Visible Excellence in Screen Media Entrepreneurship Scholarship (ScreenME-Net)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Ireland,Estonia,Belgium,Finland,Sweden,Denmark
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 880176.25
EU funding (EUR): 880176.25
Participants: 8
Project status: SIGNED

The objective of the ScreenME-Net project is to enhance excellence in screen media entrepreneurship scholarship at Tallinn University (TLU), to increase its networking position and visibility in this scholarly field, and to ensure sustainability of the impact of this project, mainly through the institutionalization of a screen media entrepreneurship research hub, the so-called ScreenME-Hub, at TLU. In terms of enhancing excellence in scholarship, the project aims at positively impacting all four pillars of scholarship (Boyer, 1990): discovery, integration, teaching and application. The objectives will be achieved through networking and collaboration activities with an interdisciplinary set of internationally-leading research institutions with strong expertise in entrepreneurship teaching and research as well as in various academic disciplines and scholarly areas of high relevance to understanding current dynamics in media industries and their wider societal effects. These partners are: Technical University Ilmenau (Germany, TUIL_IfMK), Lappeenranta-Lahti University of Technology LUT University (Finland, LUT), Jönköping International Business School and its Media Management and Transformation Centre (Sweden, JIBS_MMTC), Aarhus University (Denmark, AU_CMIP), Munster Technological University and its Hincks Centre for Entrepreneurship Excellence (Ireland, MTU) and Vrije University Brussels (Belgium, VUB_SMIT). Not only do these partners have a high level of scientific capacity and international reputation, they are also well-integrated into the relevant international research and collaboration networks and have shown excellence in early stage researcher development as well as research management and administration skills. The experience, knowledge and authority of these leading institutions will provide a perfect guide to TLU in achieving sustainable and visible excellence in screen media entrepreneurship

Keywords: entrepreneurship,media industries,screen media,media management