Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
An Integrated Cyber Security Risk & Resilience Management Platform, With Holistic Situational Awareness, Incident Response & Preparedness Capabilities (SYNAPSE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Innovation actions
Countries involved: Italy,Germany,Greece,Cyprus,Spain,Ireland,Norway,Switzerland
Call: Improved monitoring of threats, intrusion detection and response in complex and heterogeneous digital systems and infrastructures (HORIZON-CL3-2022-CS-01, 2022)
Start date: 2023-11-01
End date: 2026-10-31
Duration (months): 36.0
Total project cost (EUR): 7573750.0
EU funding (EUR): 5964850.0
Participants: 15
Project status: SIGNED

SYNAPSE aims to design, develop & deliver an Integrated Cyber Security Risk & Resilience Management Platform, with holistic Situational Awareness, Incident Response & Preparedness capabilities. The proposed platform will encompass: (i) Incident Response through process automation and orchestration mechanisms, also covering organisational/business aspects (e.g., business continuity processes); (ii) AI-enhanced Situational Awareness, encompassing extraction & analytics of actionable and pertinent Cyber Threat Intelligence (CTI), along with attack early warning & threat hunting systems; (iii) Preparedness through cybersecurity, privacy & business continuity training, covering different training delivery means, allowing it to tailor the delivery method to the content; (iv) Technical & economic risk management, integrating outputs of (i)-(iii) above and supporting risk-benefit analyses (including what-if scenarios) to inform decision-making and enable risk transfer schemes with Smart Contract-enabled cybersecurity insurance; (v) Continuous feedback between (i)-(iv) above, along with standards-based sharing, alerting & reporting (intra- & inter- Member State), based on outputs of (i)-(iii) above, thus enabling the establishment of shared situational awareness, coordinated response and joint preparedness

Keywords: intergrated risk management,security orchestration automation and response,cyber range,cyber threat intelligence,user and entity behaviour analytics,business continuity,cybersecurity insurance
Introducing deuterium for next generation chemical biology probes and direct imaging (deuterON)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1499469.0
EU funding (EUR): 1499469.0
Participants: 1
Project status: SIGNED

The ideal microscopy experiment would take place in native cells without genetic engineering, with 3-dimensional resolution on the single molecule scale (<10 nm) by observing the endogenous molecule itself. I propose the introduction and use of deuterium (“deuterON”) as a general method for a multimodal approach, to i) synthesize a first-in-class deuterated cyanine (Cy) fluorophore for super-resolution imaging, ii) to design and test deuterated, next-level photoswitches to restore vision, and iii) use these probes and deuterated drugs for direct and bioorthogonal, spectroscopic imaging. In particular, deuterated Cys will allow stochastic reconstruction microscopy (STORM) by using near infra-red light to break new ground in protein localization in live tissue, opening the gates for thick sample imaging (~100 m axial) with retained super-resolution (~20 nm). In addition, deuterated azobenzene photoswitches will be designed to finally reach the indispensable, and to-date unobtained light sensitivity to remote control neural signalling in vivo. Lastly, the use of "label-free" labelling and imaging will be explored with deuterated drugs to observe drug uptake and metabolism by utilizing the unique properties of the carbon-deuterium bond in Raman spectroscopy. Coupled to a confocal microscope, deuterated drugs will be tracked in native and live cells, without any genetic engineering strategies, and on the molecule of interest itself, reducing perturbations and artefacts to a minimum. This ground-breaking approach holds promise to be generalizable to Chemical Biology disciplines, and as an unconventional, yet attractive and powerful method to design and synthesize next generation small molecule probes. Developing a pipeline for these aims will be a game changer, with ramifications for the life sciences, cell biology, drug development and with prospective translational impact.

Keywords: deuterium,fluorescence,microscopy,photoswitches,raman spectroscopy
Multidimensional in vivo metabolic flux analyses: Resolving immune cells based on in vivo metabolic phenotypes (4Dplus_Metaflux)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Ireland
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-06-01
End date: 2024-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The development of better immunotherapies is being hammered by our lack of understanding about immune cell metabolism in vivo at the sites of disease. We know that immune cell metabolism is pivotal in controlling immune function. For instance, disrupting Natural Killer cell metabolism prevents them from killing cancer cells. Cellular immunotherapies for diseases like solid cancer are underperforming and one central reason for this is the metabolic pressure exerted on immune cells in solid tumours. The core problem is that we cannot currently measure the metabolism of immune cells at the site of disease. As a result, the biopharma industry is ill equipped to design immmunotherapies that are effective at these sites in the face of the metabolic stress. My ERC-CoG project (DC_Nutrient) has developed a new type of nutrient uptake assay with single cell resolution that can be used to probe metabolism in vivo. This is highly informative because the uptake of nutrients is the first limiting step for cellular metabolism. The core advance in our approach is to use bioorthogonal chemistry to attach a fluorophore to the nutrient after it has been transported into the cell. This bypasses all the pitfalls and failings of previous attempts to develop such assays using fluorophore tags. This PoC will advance this technology to simultaneously measure the uptake of 3 separate nutrients into immune cells at the site of disease, all with single cell resolution. Combined with an in vivo measurement of protein translation this will provide 4 dimensions of metabolic flux analysis for each cell analysed by multiparmetric flow cytometry. This innovative idea will provide a licensable assay technology that will be of high value to the biopharma industry as it will enable preclinical mouse studies to gain a detailed understanding of the metabolic changes occurring in immune cells at the site of disease. This technology will drive innovation towards metabolically enhanced immunotherapies.
Modeling mICRObial LIFE in Polluted AQuiferS (MICROLIFEPAQS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands,Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-10-31
Duration (months): 25.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 2
Project status: CLOSED

Groundwater pollution is a significant threat to human health and ecosystems and one of the leading causes of limited access to good-quality water resources worldwide. Biodegradation is an effective means to remove chemicals from the environment, and several remediation techniques benefit from degrading bacteria to eliminate pollution from aquifers. Reactive Transport Models (RTMs) have proved to be valuable tools to support remediation. However, efforts made so far to model biodegradation in polluted aquifers have been incomplete, as they did not thoroughly consider that microorganisms’ behaviour in groundwater depends on their metabolism and physical interaction with the porous medium. The MICROLIFEPAQS project aims at implementing a novel and interdisciplinary approach for pollutant biodegradation modelling as reliable support for groundwater remediation optimisation. Modern and newly collected microbiological omics data will constrain RTMs of degrading bacteria with information about their metabolism. Moreover, microorganisms will be considered as reactive biocolloids moving in the subsoil. This omics-informed RTM of biocolloids will be tested in a contaminated test site, considering naturally occurring bacteria or injected/stimulated for bioaugmentation/biostimulation. Working on this project at the Delft University of Technology will enrich my existing expertise with advanced skills in reactive transport modelling and microbiological analysis modelling. Moreover, the secondment at the Technical University of Denmark will provide additional knowledge about innovative contaminated site investigation and advanced (bio)remediation strategies. This transfer of knowledge will foster research and innovation on these topics. As the United Nations and European Union strive to eliminate pollution to reduce the risk for human health and ecosystems and secure safe water resources and sanitation for everyone, this project will also contribute to this global challenge.

Keywords: biodegradation contamination plume organohalide reducing bacteria reactive transport modelling genome scale constraint based metabolic models heterogenous porous media groundwater
Laser-patterned hierarchical porous electrodes for the foreseen Iontronics technology (LASERION)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2025-10-31
Duration (months): 34.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 2
Project status: SIGNED

LASERION’s main objective is to develop robust and efficient hierarchical porous laser-patterned film (LPF) carbonized electrodes (CE) for unprecedented ion sensing by electrochemistry. LASERION’s ambition, aligned with the EU Green deal 2050 carbon neutrality roadmap and United Nations goal 9, is to contribute simultaneously to climate neutrality while proposing a new technological path to reinvent the modern electronical industry. For that purpose, the research fellow (RF) will conjointly with the host scientist, prepare sustainable electrodes through valorization of bio-based polymers via three material engineered strategies centered at the CO2-laser carbonization, namely porogen agents (before, WP1a), controlled atmosphere (during, WP1b), and conductive polymers (after, WP1c). The resulted carbonized based electrodes, using lignosulfonates as the carbon source, will be characterized with an extended portfolio of routine (WP3a) and advanced (WP3b) techniques listed in section 3.1. The same LPF-CE will be tested via electrochemistry in a newly engineered designed cell (WP2). Such electrochemical tests are divided in two configurations: standard (WP4a) three-electrodes cell (working, counter, and reference) and a more sophisticated cell (WP4b) with an additional potentiostat to provoke an electromagnetic stimulus. Combinedly, WP5 deals with training, communication, dissemination, and strategic network building. Finally, WP6 is dedicated to project management, specifically in the technical, administrative, financial, and IPR aspects. By accomplishing these ambitious work packages, tasks, and objectives towards unprecedented LPF-CE evaluating their ion sensitivity capacity in liquid using a new custom bipotentiostat electro-cell, LASERION attempts to provide a qualified training to the RF while delivering a potential technological readiness level 3 with an untapped modern CO2-laser pyrolysis conversion of lignin-based pulping residues for a needed circular economy.

Keywords: iontronics,laser patterned,conductive polymers,porous,neuronal network,city map
Precision engineering for plant resilience: MYB-driven tissue-specific deposition of essential plant biopolymers (MYBEST)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

Environmental stressors such as nutritional imbalances, severe temperature, drought, and salinity are detrimental to plant growth. As a major strategy for adaptation to environmental stressors, plants have evolved extracellular barriers as part of their cell walls made of aliphatic biopolymers, cutin and suberin, along with their associated waxes. Cutin and cuticular waxes form the cuticle that covers the outer surfaces of leaves, fruits, and flowers. Suberin, on the other hand, is present in the extracellular space of inner tissues, such as endodermis, periderm, and exodermis, as well as the seed coat. Both cutin and suberin act as barriers, preventing water loss and nutrient leakage while also shielding the plant from pathogens. Despite decades of studies on these biopolymers, many essential aspects of their biosynthesis and assembly remain unclear. Among these is our understanding of the assembly of cuticle and suberin monomers in the extracellular space, as well as the control of the polymerising machinery both developmentally and environmentally. A few members of the GDSL-esterases/lipases (GELP) family have been shown to be involved in the polymerisation of tomato fruit cuticle and Arabidopsis thaliana root suberin. Intriguingly, another subset of GELPs has been shown to be able to degrade cutin or suberin, implying a complex mechanism that plants have evolved to modulate the dynamics of these polymers. On a regulatory level, several MYB transcription factors have been shown to be important in controlling the developmental and tissue-specific responses of suberin and cutin. The proposed research aims at uncovering the mechanisms of MYB-directed and GELP-mediated cuticle and suberin assembly and plasticity during growth and adaptation. Importantly, as part of our proposed work, we intend to use MYBs to manipulate suberin and cutin deposition at the tissue level to create new crop resilience strategies to environmental stressors including drought and salinity.

Keywords: myb,gelp,suberin,cuticle,dynamics,arabidopsis,tomato
POst-quantum SEcure dIgital iDentities for EurOpean solutioNs (POSEIDON)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Research and Innovation actions
Countries involved: Spain,Austria,Germany,Poland,Belgium,Greece,United Kingdom
Call: Post-quantum cryptography transition (HORIZON-CL3-2024-CS-01, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 5999555.0
EU funding (EUR): 5999555.0
Participants: 15
Project status: SIGNED

To advance towards the strategic goal of achieving both a tangible and effective increase in cybersecurity/resilience and a more secure online environment across the EU with technological sovereignty, a fundamental pillar will be the implementation of a secure and efficient transition from pre- to post-quantum cryptography sustained on tools implementing a hybrid approach. POSEIDON will pave a credible pathway in this regard by developing novel digital technological capabilities in this domain, and by evaluating them in realistic high-impact scenarios. The developed techniques will innovate at the level of more mature, scalable PQC algorithms including HW optimization and support, identity protocols based on them, and methodologies to facilitate integration in different systems. They will support to the maximum extent protection of data both at rest and in transit (confidentiality, integrity, authenticity) and will implement measures and provide application-oriented recommendations to incumbent stakeholders and fora (institutional level like NIS PQC subgroup and EUDI Cooperation Group, public-private partnerships, associations like ECSO with Working groups dealing with cybersecurity priorities, among others) for the widespread industrial adoption of post-quantum crypto. Specifically, POSEIDON will focus on providing robust and reliable solutions in digital identity management applications, given the critical importance of protecting citizens and businesses against the rising threats of identity-centric cyberattacks (i.e. identity compromises and misuse of valid credentials among others. POSEIDON will address the provision of crypto-agile, PQC-ready identity tools in a moment where new applications are being introduced for pan-European digital identity aligning with EU advancements and security policy like NIS2, CRA, CSA, etc

Keywords: identity,euwallet,transition,hybrid cryptography
Solution-processed toxic metal-free alloy colloidal quantum dots for self-powered near-infrared photodetector application (SolProDet)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 2
Project status: SIGNED

Self-powered near-infrared (NIR: 0.7–2.5 μm) deteSelf-powered near-infrared (NIR: 0.7–2.5 μm) detection technologies attract immense interest both from scientists and industry experts due to their vital applications in environmental monitoring, night vision, and imaging in remote locations. However, available conventional NIR photodetectors (PDs) are based on costly fabricated inorganic semiconductor materials or toxic heavy metal-containing quantum dots (QDs), which restrict their use in electronics and biomedical applications. Silver chalcogenide-based (Ag2E, E= S, Se, Te) QDs have recently joined as new promising toxic heavy metal-free materials for NIR detection, making them appealing from health and environmental safety perspectives. Nevertheless, the development of Ag2E-based NIR PDs is in its initial stage and far behind the commercially available devices due to the lack of protocols for device-relevant thin film fabrication with favourable device architecture. In this project, we propose a novel approach to solve this issue, which consists of two strategies: (i) chemical synthesis of small Ag2E and MAgE alloyed QDs followed by thin film preparation with favourable legend and thickness, (ii) PD architecture with proper electrode and electrode distance. To achieve this, the first strategy will develop synthesis protocols to control the size of Ag2E QDs and optimize their absorption and electronic properties by ligand exchange for NIR PDs application with different metal electrodes and electrode distances. In the next stage, the potential metal alloy will be introduced into Ag2E QDs by cation exchange, followed by studying the optical and electrical properties to optimize the synthesis and thin film quality for self-powered NIR PDs. In the last stage, the work will concentrate on the optimization of photodiodes using the best-suited Ag2E and MAgE QDs and demonstrate the application potential and related extensive characterization of these devices for upscaling.

Keywords: nir photodetector,qds metal alloy,metal exchange,self powered photodetectors,qds photodiode,
Thinking Infrastructurally about Business Activities and Economic Value for a Socio-Ecological Transformation (ReValue)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2025-08-31
Duration (months): 35.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

More than 70% of global carbon emissions responsible for climate change are nowadays produced by only 100 firms. This makes transforming corporations towards more sustainable pathways a crucial challenge of today. ReValue explores an innovative approach to meet this challenge, by combining new infrastructural perspectives in legal analysis with philosophy and the use of social science methods. Until now, the policy and scholarly focus has been placed on setting ambitious carbon-neutrality goals for leading firms in key industries with the aim of greening their global supply-chains. ReValue transcends this focus. It does so by broadening the focus to those actors with the regulatory authority to constitute markets and thereby to re-configure the rationalities that shape corporate decisions. For these purposes, ReValue focuses on two key private governance institutions that currently shape the preferences of transnational corporations in the global economy: (1) the legal-regulatory infrastructure provided by predominant accounting institutions, which govern what counts as income or wealth in financial markets; and (2) the legal-regulatory infrastructure provided by predominant stock-exchange institutions, which govern how the price of shares and other financial instruments are determined. These private governance institutions do not just report income, price, or risk. ReValue investigates the extent to which they rather performatively shape the information that they purport to describe, through private regulatory choices that configure corporate preferences and market orders and thereby can transform them towards more sustainable pathways by determining what is susceptible of economic value and how it is valued.

Keywords: transnational law global governance sustainable corporate governance corporate social responsibility business regulation private governance global administrative law