Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hanover experimental lung research project (XHaLe)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-06-01
End date: 2024-05-31
Duration (months): 72.0
Total project cost (EUR): 1989250.0
EU funding (EUR): 1989250.0
Participants: 1
Project status: SIGNED

Non-neoplastic lung diseases (NNLD), such as COPD and interstitial lung diseases rank second among the causes of death and NNLD appear as a growing EU wide challenge. They are characterized by irreversible remodeling with a relentless loss of lung function and a 5-year survival of only 30%. This dysfunctional reaction to injury can be triggered by particulate matters with macrophages (MO) as the key regulators. Wholesale therapeutic suppression of the inflammome actually increases the risk of death, whereas targeted therapy of signalling cascades by novel pharmaceuticals, e.g. nintedanib, only slows disease progression. Thus lung transplantation remains the ultima ratio. However, available grafts are limited, treatment costs are high and the 5-year survival barely surpasses 50%. Therefore novel approaches to understand, prevent and ultimately cure NNLDs are urgently needed. Towards this goal my group focusses on both, the main effector cell in NNLD, the myofibroblast, and the inflammome and particularly MOs, as these orchestrate both, lung healing and remodeling. Modulating the pulmonary immune system, rather than subduing it, holds significant promise. To this end, we have to understand the very early events in NNLDs. There are 2 major obstacles for efficient research: i) the lack of adequate animal models and ii) the availability of human specimens. Therefore we established a unique platform for NNLD: we utilize fresh explanted human lungs from Europe’s largest LuTx program and set up a singular 24h/7d workflow, ensuring short ischemia and tissue viability. In the last years, we have worked up over 500 lungs, acted as an international multiplier for pulmonary research, patented new imaging techniques and described novel diseases. Our understanding MO biology in NNLDs showed us the great potential in macrophages. Now we are going to use these macrophages as potential therapeutics. Hereby we will make a difference in translational medicine in Europe and the world.

Keywords: non neoplastic lung diseases,lung transplantation,lung remodelling,organ dysfunction,macrophages,fibrose
Customised lipid supplementation of culture media for efficient in vitro cell culture applications (Refeed)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Italy
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cell culturing allows scientists to grow cells under controlled conditions outside their natural environments. Each cell type requires a medium in which it can grow that is able to supply all nutrients the cells need for subsistence. Historically, cell biology has always worked on nucleic acid and proteins, leaving lipids behind. In fact, lipids have always received little consideration in academia and from biotechnology companies. Therefore, culture media manufacturers have always considered the lipid intake and its composition quality unimportant, which justifies their use of low-cost and low-quality molecules. Remembrane has proven the importance of lipids in membrane composition and properties, and have developed a sophisticated process for customising lipid supplements able to recreate a membrane environment similar to the one that cells have in-vivo. The lipid supplements are tailored to specific cell type and protocol, and are able to enhance the quality and reliability of in-vitro experimental models. The Phase 1 project will be focused on establishing a complete scale-up strategy, including the elaboration of an industrialisation plan, a scalable business model and commercialization strategy and on planning new collaborations and partnerships with end users to build up strong successful business and use cases.

Keywords: cell culture,in vitro,cell culture media,cell therapy,customised lipid supplements,early drug discovery,preclinical testing,animal testing,regenerative medicine
Intermediate Compressor Case Duct Aerodynamics (IDA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Sweden,United Kingdom
Call: Intermediate Compressor Case Duct Aerodynamics (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-04-01
End date: 2021-04-30
Duration (months): 37.0
Total project cost (EUR): 513242.5
EU funding (EUR): 513242.5
Participants: 2
Project status: CLOSED

To reduce fuel-burn and CO2 emissions from aero gas turbines innovative, very-high bypass ratio and smaller ultra-high pressure ratio core engine technologies are required as this will increase their propulsive and thermal efficiency. However, this makes the design of the intermediate compressor ducts connecting the various compressor spools much more challenging as the change in radius becomes much greater. The ability to design shorter, more aggressive ducts is advantageous from a performance and weight saving perspective but flow separation must be avoided if efficiency is not to be compromised or the downstream compressor performance not adversely affected. This programme of work will establish and validate improved and more integrated duct technologies that will contribute to the development of the very-high bypass ratio turbo fan demonstrator (UltraFan™). A fully annular, low-speed test facility incorporating a representative compressor stage will be used to validate, at low TRL, an initial compressor inter duct design. A representative bleed port will also be added upstream of the compressor to allow compressor/bleed/duct interactions to be studied. This bleed port is required in the engine to extract ice and water but currently little is known about how it affects the compressor or duct aerodynamics. The results will be used to develop and experimentally validate future potential duct technologies for the UltraFan™ engine and other very high bypass ratio applications. This will include a second design solution optimised for a more effective bleed extraction and/or lower impact on system performance and stall margin. In parallel to the experimental work this project will also establish best practice for advanced, yet efficient, CFD methods (e.g. hybrid RANS/LES). The experimental data will be used to validate these methodologies which will provide increased numerical accuracy but with a reasonable turn-over time and robust performance.

Keywords: experimental,aerodynamics,ultrafan
Appearance Printing - European Advanced Research School (ApPEARS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Israel,Germany,Germany,Germany,Italy,Sweden,Norway,France,France,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-04-01
End date: 2023-11-30
Duration (months): 56.0
Total project cost (EUR): 4265884.44
EU funding (EUR): 4265884.44
Participants: 15
Project status: SIGNED

The international manufacturing industry is undergoing radical changes in the way items are digitally printed and fabricated. From the home to aerospace, the speed of change has had impacts on traditional methods of printing, and which has led to incomplete understanding of the design and reproduction workflow, for example accurate measurement of the optical and material properties, gloss, modelling and controlling printing systems beyond colour. To provide a strategic response to the needs of the industry, the group Appearance Printing – European Advanced Research School (ApPEARS), is a robust European network that builds upon the extensive experience across the partners, and is at the forefront for leading an innovative training programme. It will facilitate the successful completion of high quality PhDs by a significant body of ESR students through collaborative supervisory and research training practices which encompass innovative cross-disciplinary methodologies. It will co-create student research projects with cross sector partners and develop career potential through a structured programme of training events and placement opportunities across Europe. It will produce models of good practice for training and cross-disciplinary research that can be applied in the arts, science and technology fields.

Keywords: material appearance,gloss,printing,colour,measurement,metrology,workflow,application,business and innovation,modelling,training,simulation,visualisation,proofing,reproduction
Hybrid Carbon-free electrically driven fishing longliner with low power methanol combustion engine for propulsion back-up and auxiliary equipment (RENShip)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Iceland
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Out of NAVIS high commitment with a greener shipbuilding industry and our many years’ experience in naval architecture and engineering design, we have developed a 100% renewable energy propelled vessel. With the objective of maximizing operational efficiency and green energy whilst improving the handling of the catch, we have taken the current hybrid ship concept to a step further and developed RENShip. Our innovative RENShip is a small fishing long liner vessel powered by a revolutionary hybrid system including a single small combustion engine powered by methanol and a set of lithium batteries, connected to onboard wind turbine and solar panels for supercharging. European fishing fleets are major oil consumers and so, they are greatly responsible for global greenhouse gas emissions from the world’s fleets. Moreover, current ship engines are excessively powerful diesel engines of 50-60% efficiency, resulting in excess of fuel combustion and cost (specially as fossil fuels prices increase over 50%), as well as causing noise and vibration impacting fishing effectiveness and crew’s health. With benefits such as >30% reduction in fuel consumption and associated CO2 emissions and air pollutants (SOx, NOx), considerable reduction in underwater noise, access to fish product’s ecolabels and new tailored displacement hull form, RENship demonstrates its great business opportunity and potential to shift current shipping practices towards efficiency, lower costs and greener operation. Currently located at TRL6, we will integrate all components into a new design to build a pilot ship and validate RENShip in operational conditions, reaching TRL9. RENShip will be the first vessel totally operated by renewable energy and the smallest fishing vessel running with a hybrid propulsion system. There is currently one RENShip design we plan to take to the market with an average market price of €2M (10% profit margin), which will report €100K per boat to NAVIS.

Keywords: ship,fishing,renewable energy,vessel,hybrid ship,hybrid system,methanol engine,wind turbine,solar panel
Modelling Anthropocene Trophic Cascades of the Judean Desert Ecosystem: A Hidden Dimension in the History of Human-Environment Interactions (DEADSEA_ECO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Israel
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 1499562.5
EU funding (EUR): 1499562.5
Participants: 1
Project status: SIGNED

This project aims to explore the effects of human settlement intensity on desert ecological community structure, focusing on the hitherto unstudied phenomenon of trophic cascades in antiquity. Its key research question is whether human-induced changes in arid land biodiversity can feedback to affect natural resources important for human subsistence, such as pasture and wood. The role of such feedback effects in ecological systems is increasingly acknowledged in recent years in the biological literature but has not been addressed in the study of human past. The research question will be approached using bioarchaeological methods applied to the uniquely-preserved material record from the middle and late Holocene settlement sequence (approximately 4,500 BCE to 700 CE) of the Dead Sea Ein Gedi Oasis, and to the contemporary palaeontological assemblages from caves located in the surrounding Judean Desert. The proposed research is expected to bridge between aspects of current thinking on ecosystem dynamics and the study of human past by exploring the role of trophic cascades as an invisible dimension of Anthropocene life in marginal environments. The study of the history of human impact on such environments is important to resource management planning across a rapidly expanding ecological frontier on Earth, as climate deterioration brings more people in contact with life-sustaining and sensitive arid land ecosystems.

Keywords: archaeozoology,human ecology,desert,sustainability,anthropocene
VERA: Extracellular VEsicles, miRNAs and particulate Air pollution: developing a new tool to identify subjects with high exposure-associated cardiovascular risk (VERA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-04-01
End date: 2019-09-30
Duration (months): 18.0
Total project cost (EUR): 149939.0
EU funding (EUR): 149939.0
Participants: 1
Project status: CLOSED

Air pollution exposure, in particular the particulate matter (PM) component, has been consistently linked to an increased risk of developing acute and chronic cardiovascular diseases (CVD). The SPHERE ("Susceptibility to Particle Health Effects, miRNAs and Exosomes") project was granted by ERC-2011-StG 282413 and hosted by the “Università degli Studi”, Milan, Italy, to examine possible molecular mechanisms underlying the effects of PM exposure in relation to health outcomes. In this project, in particular, we investigated the role exerted by extracellular vesicles (EV) and their miRNA cargo in mediating the cardiovascular effects of PM exposure. EVs might be the ideal candidate to mediate the effects of PM, since they could be potentially produced by the respiratory system, reach the systemic circulation and lead to the development of cardiovascular effects. In the SPHERE study, we confirmed in a population of obese subjects that PM is able to stimulate EV release in plasma and we were able to identify a EV-specific miRNA signature, responsive to PM exposure. One of the most important gaps in our current knowledge regarding PM-related cardiovascular health effects is the identification of susceptible subjects. This identification would provide the groundwork for the development of prevention strategies and of targeted treatments. The Proof of Concept project VERA (Extracellular VEsicles, miRNAs and particulate Air pollution: developing a new tool to identify subjects with high exposure-associated cardiovascular risk) aims to confirm the commercial and technological feasibility of a tool for testing EV-specific miRNA expression, in order to identify subjects with an higher susceptibility to PM. We propose scientific activities which will validate the project SPHERE findings, extend them to the general population, will use in -vitro experiments and will support the development of a commercial kit aimed at evaluating the cardiovascular risk related to PM exposure.

Keywords: air pollution,susceptibility,cardiovascular disease,extracellular vesicles,micrornas
BRIDGING THE GAP BETWEEN HORIZONS THROUGH TRANSNATIONAL COOPERATION OF ITS NCP SUPPORT STRUCTURES (Bridge2HE)

Framework: Horizon 2020 — Societal Challenges
Action type: Coordination and support actions
Countries involved: Austria,Iceland,Spain,Ireland,Germany,Italy,Cyprus,Switzerland,Belgium,Finland,Finland,Croatia,Hungary,Lithuania,Slovakia,Sweden,Moldova, Republic of,Greece,Poland,France,Czechia,Luxembourg,Portugal,Portugal
Call: Fostering transnational cooperation between national support structures (e.g. National Contact Points): ensuring a transition between Horizon 2020 and Horizon Europe (H2020-NSUP-2020, 2020)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 2025972.21
EU funding (EUR): 1999700.78
Participants: 28
Project status: CLOSED

The NCP systems are support structures established by MS and AC and recognized by the European Commission in order to help participants to access the different EU Programme opportunities. For Horizon 2020 (H2020) there are 21 NCP defined functions apart from the NCP coordinator, giving support to participants across the different parts of H2020. In order to ensure cooperation among NCPs from different countries, improve mutual learning between them and develop dedicated tools and services for participants, the European Commission has historically funded the NCPs through NCP networks CSA projects, in variable geometry of partners, covering typically one NCP “function” per project and renewing it, with a follow-on project, approximately at the middle of each Framework programme. Taking advantage that the current H2020 NCP network projects finalize at the end of 2020 and the new NCP network projects will not start at least until Q3 of 2021, this project, under the leadership of the national NCP coordinators has a unique window of opportunity to lead the effective integration of the NCP systems into a coherent frame of work for Horizon Europe. Our project, Bridge2HE, is the agreed response of 22 NCP host organizations across Europe to the challenge of an efficient transition to Horizon Europe, both from the NCP systems’ perspective but also from the support to participants’ perspective. Our project does not only enable a degree of continuity to the current NCP structures and network coordination but also it goes a step further making a real integration of the NCP networks offer under a common portal, the Horizon Europe NCP Portal. During this transition Bridge2HE will implement more than 20 training activities; tools and services for NCPs and applicants; 6 big brokerage events; 2 full proposal checks events; 2 NCPs Workshops for the continuous improvement of the NCP system and a number of special activities to push the low participant countries.

Keywords: national contact points,horizon europe
UKMidsINNOV (UKMidsINNOV)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: United Kingdom
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-07-01
End date: 2014-12-31
Duration (months): 6.0
Total project cost (EUR): 49358.75
EU funding (EUR): 39487.0
Participants: 1
Project status: CLOSED

UKMidsINNOV will establish new services in the English Midlands region to enhance the innovation management capacity of SMEs. The project will provide high-quality specialised consulting services to improve innovation management capacity in SMEs and provide beneficiaries of the SME instrument with access to coaching services.

Keywords: establishing services enhancing the innovation management capacity of smes in the enterprise europe network
A Dynamic Economic and Monetary Union (ADEMU)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,France,Czechia,United Kingdom,United Kingdom,Portugal
Call: Resilient and sustainable economic and monetary union in Europe (H2020-EURO-SOCIETY-2014, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 8
Project status: CLOSED

In response to the European debt crisis and associated deep recession, a number of important steps have recently been taken towards redesigning the institutional architecture of EMU, based on the roadmap outlined in the Van Rompuy Report (2012). But these institutional innovations – in particular the ‘fiscal compact’, the ESM, the SSM and the SRM – retain relatively weak theoretical foundations. In particular, there is a noticeable gap between policy-oriented analyses of the precise EU challenges, and the major developments in dynamic macroeconomic theory of the past three decades. ADEMU brings together eight research groups from leading European institutions with the aim of closing this gap. It studies the overall monetary and fiscal structure of the EU and the euro area, and the mechanisms of fiscal policy coordination among member states, with specific focus on: i) ensuring the long-term sustainability of EMU, addressing issues such as debt overhang, fiscal consolidation, public debt management, risk-sharing within the union, and crisis management mechanisms; ii) building resilience to economic shocks, with special emphasis on the coordination of fiscal policies, fiscal multipliers and labor market risks; and iii) managing interdependence in the euro area, analyzing both fiscal and financial spillovers and the effects of macroeconomic imbalances on financial and money markets, and, to confront these issues, new forms of banking regulation and monetary policy. ADEMU is at the frontier of dynamic macroeconomic research, and the project will generate new knowledge that will be used to provide a rigorous assessment of the current institutional framework, and detailed proposals for improving it. It will also be a focal point in debates among academics, policymakers and other stakeholders regarding the implementation of new policies. The scope of the project will include a full consideration of political economy and legal dimensions to alternative institutional reforms

Keywords: economic and monetary union,risk assessment,credible policies,risk sharing,fiscal imbalances,macroeconomic policy coordination