Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
French Institutes for Advanced Study - Fellowship Programme (FIAS-FP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: France
Call: MSCA COFUND 2024 (HORIZON-MSCA-2024-COFUND-01, 2024)
Start date: 2025-08-01
End date: 2030-07-31
Duration (months): 60.0
Total project cost (EUR): 4042000.0
EU funding (EUR): 4042000.0
Participants: 1
Project status: SIGNED

The French Institutes for Advanced Study (FIAS) Fellowship Programme strengthens high-level scholarship and international mobility in the European Research Area by upgrading the offering of scientific residencies to experienced researchers in the Social Sciences and the Humanities (SSH) and in other sciences interfacing with them. The Institutes for Advanced Study (IAS)—located in Cergy, Lyon, Marseille, Montpellier, Nantes, Orléans-Tours, and Paris—form a large scientific consortium that proposes a unified entry point in France to seven first-class research, training and networking residencies. The 112 fellowships to be offered will provide experienced scholars worldwide with the opportunity to spend 10 months in leading scientific, economic and cultural regions in Europe. FIAS supports individual professional development as fellows benefit from unsegmented time to conduct bottom-up research with the greatest freedom and enjoy outstanding material and intellectual conditions. Thanks to the IAS’ scientific and extra-academic support, the FIAS experience brings fellows to the next level of excellence and generates a significant boost to their careers: 1. It enables fellows to produce important work that would have taken them years to achieve; 2. It stimulates new perspectives on research thanks to daily interaction and collective intelligence of the international and multidisciplinary cohort of fellows and to the individual mentoring; 3. It enriches the fellows’ professional networks with local and international contacts in academia and beyond to develop long-term collaborations; 4. It offers vast training opportunities that improve fellows' research and non-academic skills and level up their individual professional achievements and prospects. FIAS will impact the career development of each fellow, consolidating its strong track record in terms of recruitments and promotions, publications, awards and grants, and extra-academic recognition.

Keywords: excellence innovation incubation multidisciplinary mentoring
Understanding iNKT cell Metabolic features in GlioBlastoMa tumours to improve Immunotherapy (ImmunoGBMet)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 1
Project status: SIGNED

Glioblastoma (GBM) is one of the most aggressive and fatal types of tumours with one of the worse survival rates. Although immunotherapy is a remarkable and fast-growing field on cancer treatment it still faces the challenge that solid tumours are very suppressive for immune cells. This suppressive tumour microenvironment (TME) is known to affect immune cells in different ways, as through the expression of inhibitory ligands and cytokines. Recently, it has been shown that lipids and other metabolites are increased in the TME and affect metabolic pathways in immune cells leading to their dysfunction. NKT cells are a distinct subset of lymphocytes that react to lipids presented via the CD1d molecule and produce a range of cytokines upon activation. They play a role in tumoral immunity either through cytotoxicity or by activating other cytotoxic lymphocytes. However, little is known about their function in the GBM tumour and how the TME affects it. This project will leverage expertise in immunometabolism to describe the alterations in NKT cell metabolism that lead to their dysfunction in the GBM TME. We will take advantage of single-cell metabolic tools and proteomics analysis to unveil the most altered pathways, then, set up the best approaches to engineer NKT cells and make them resistant to the adverse TME. Our findings will potentially pave the way to new strategies on engineering immune cells for cancer immunotherapy and other serious conditions.

Keywords: inkt cells,glioblastoma,immunometabolism,immunotherapy,tumor microenvironment
Understanding Neutral Weed Communities - Crops Interactions and Identification of Artificial Intelligence Algorithms for Species-Specific Weed Management Using Robots (NEUTRAWEED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,United States,Argentina,China,Kenya,France,Greece,Spain,Netherlands
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 1249228.57
EU funding (EUR): 1237400.0
Participants: 16
Project status: SIGNED

The overarching objective of NEUTRAWEED is to form an international and inter-sectoral network of 16 organizations in four continents (Europe, Africa, Asia, and America) working on a joint research program in the fields of weed ecology and management, artificial intelligence (AI), and robotics. New sustainable weed management solutions are requested since the over-reliance on chemical control and intensive tillage in over-simplified cropping systems are now questioned because they have many drawbacks. As a solution, we propose the promotion of Neutral Weed Communities (NWCs), which are weed communities that can coexist with the crops without reducing crop yield or quality compared with weed-free conditions. In this 4-yer research plan, we propose to 1) identify NWCs in diverse cropping systems and study their interactions with crops and other biotic agents, 2) investigate their effect on ecosystem services provision, 3) develop weeder robot prototypes for weed-specific analysis; 4) identify AI algorithms for weed species-specific discrimination to test on robots to attain NWCs. A multidisciplinary and intersectoral approach will be used to comprehend the multiple interactions between weeds and crops under four aspects: agroecological, physiological, molecular, and microbiological. Using weed species images, AI algorithms will be developed and tested on autonomous robots to attain NWCs by selectively removing only highly competitive weed species while leaving only the beneficial ones. The staff members will develop new skills and competencies, will be exposed to new research environments, and will have their career perspectives broadened. NEUTRAWEED will advance research by fostering the interconnections among countries, providing training and education at academic and technical levels, and engaging with local, national, and international stakeholders to create shared knowledge on weed-crop interaction and new sustainable AI technological solutions to manage weed.

Keywords: agroecology,functional biodiversity,ecosystem services,pesticide use reduction,soil conservation,crop protection,beneficial organisms protection,policy development,stakeholder engagement
AUTONOMOUS FLYING SHIPS FOR INTER-ISLAND AND INLAND WATERS TRANSPORT (AIRSHIP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Countries involved: Spain,Portugal,Estonia,Finland,Luxembourg
Call: Digital aviation technologies for new aviation business models, services, emerging global threats and industrial competitiveness (HORIZON-CL5-2022-D5-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 5117262.5
EU funding (EUR): 5116012.5
Participants: 7
Project status: SIGNED

In Europe, many archipelagos and inland waterways can be found. The use of such waterways for the airborne transportation of both goods and persons has huge potential, and in many cases is the only possible way. In this cases, the transportation of goods and persons by airplanes or ships has many drawbacks. The first have the problem of cost and environmental impact, while the second, while allowing larger payloads, have the drawback of limited speed. Additionally, both are extremely low energy efficient at high speed. AIRSHIP envisions an innovative use of a known transportation mean: flying ships. Such vehicles (also known as ekranoplans or wing-in-ground -WIG- vehicles) are designed and built to take advantage of the ground effect, that allows these crafts to fly with enhanced lift and reduced drag. WIGS inherit all the advantages of conventional airborne transportation, while being more energy efficient and environmentally friendly, both from the carbon footprint and the acoustic noise pollution point of view. AIRSHIP will study and develop new technologies in zero-emission power, on-boar AI and in automatic flight control that overcome the challenging technological problems that flying in ground effect poses, allowing such vehicles to become autonomous so they can be effectively used in a wide range of business applications and services, leading to new aviation business models. Our aim is to lay the foundations of a new class of fully electrical unmanned aircraft system, the UWV (Unmanned WIG Vehicle) that brings together speed, flexibility and energy efficiency.

Keywords: wing in ground effect,autonomous vehicles,logistics,zero emissions electrical propulsion power network
Automated retinal scans for early detection of diabetic eye diseases through use of artificial intelligence (iScan)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Norway
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 3622500.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Oivi provides affordable eye care for all and prevent unnecessary blindness by providing a low-cost camera for retinal (fundus) photography, with fully automated image capture and diagnostics. Oivi is a point-of-care device for eye screening of diabetic retinopathy (DR). DR affects >160 M people worldwide and is the most common cause of blindness among working-age adults. Yet, early detection can successfully prevent vision-loss in 95% of the cases. Current solutions for DR screening are expensive and require extensive training that limits accessibility to patients, especially in developing countries. Oivi is a unique combination of automated, easy-to-use, low-cost and integrated Machine Learning/Artificial Intelligence solutions (for image capturing and DR diagnostic) in a highly portable design. Within the iScan project, we want to mature the device and its diagnostic functionalities, to clinically validate our solution and to assure regulatory approvals.

Keywords: diabetic retinopathy,eye diseases
The Role of Ascending Proprioceptive Information in Decision-Making Processes in Walking Drosophila (BottomUpFly)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 1
Project status: SIGNED

Locomotion is one of the most relevant tasks of nervous systems, allowing animals to approach food, locate a mate, and escape predators. Most types of locomotion, like walking and flying, are based on rhythmic body movements generated by local premotor networks in the nerve cord, whereas the goal of where to move is generated in the brain – e.g., a hungry fly visually locating a food source. For flexible, goal-directed locomotion, the communication between the brain and premotor networks in the nerve cord must be bidirectional. However, in contrast to descending commands from the brain, little is known about proprioceptive signals ascending from the nerve cord's premotor networks. We hypothesize that ascending information plays a vital role in decision-making and action selection processes. Before commanding the body to change direction, or to keep it from doing so to maintain a straight path, brain circuits need to consider the current stability of the body, its walking speed and direction. In this project we aim to characterize the ascending signals determining the direction of upcoming turns if the fly’s trajectory deviates from the intended one. We will identify the source of the ascending information, characterize functional differences of ascending information pathways, and determine their integration within brain circuits by harnessing the vast toolkit of Drosophila melanogaster and combining the expertise of the Chiappe group on sensorimotor integration in the brain of walking Drosophila with mine on networks controlling walking in the ventral nerve cord. This work will deepen our understanding of the function of proprioception in higher order brain functions, action selection, and decision-making.

Keywords: decision making action selection proprioception ascending information motor control
Deciphering Membrane Compartmentalization in Protein-Misfolding Bacterial Dysfunction to Re-Sensitize Multi-Drug Resistant Pathogens. (CLAMP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Spain
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-04-01
End date: 2031-03-31
Duration (months): 60.0
Total project cost (EUR): 2497271.0
EU funding (EUR): 2497271.0
Participants: 1
Project status: SIGNED

Multi-drug resistant (MDR) bacterial infections threaten all the advances in modern medicine after the industry nearly abandoned antibiotic development and no mechanism to suppress antibiotic resistance has been found. However, our results indicate that this mechanism does exist and is conserved in functional membrane microdomains (FMM) in all prokaryotes. We discovered bacterial FMM, akin to eukaryotic lipid rafts, and demonstrated their crucial role in preserving proteins correctly folded at no ATP cost. FMM are essential for pathogens survival during infections thus, FMM perturbation causes the bacterial proteome to collapse, particularly affecting heterologous proteins responsible for MDR. This leads to attenuated infections and additionally re-sensitizing MDR pathogens to antibiotics. Studying FMM will transform our understanding of cellular membrane organization and its connection to protein misfolding disorders. Accordingly, this proposal will undertake an ambitious molecular characterization of FMM and its impact on bacterial proteostasis, and we will apply this knowledge to bring closer to the clinic a battery of anti-FMM drugs that target FMM to reactivate antibiotics against MDR infections. To achieve this, a first structural goal will describe FMM molecular organization, how FMM operate to prevent protein misfolding, and the molecular principles driving the assembly of membrane microdomains in cells. Secondly, a functional goal will describe the mechanism of proteome stabilization independent of ATP and its crucial role in pathogenesis. Finally, an applied goal will be to implement anti-FMM drugs to eliminate MDR infections and re-sensitize them to conventional antibiotics. This proposal unveils a new frontier in understanding the cellular programs for membrane compartmentalization, their connection to protein-misfolding cellular dysfunction, and the possibility of applying this knowledge to revitalize classical antibiotics against MDR infections.

Keywords: staphylococcus aureus,bacterial membrane,membrane microdomains,protein misfolding,proteostasis,multi drug resistance
PHOS-SVD: PHOSpholipids in Cerebral Small Vessel Disease (PHOS-SVD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 2
Project status: SIGNED

Cerebral small vessel disease (SVD) is the leading cause of vascular dementia, plays a significant role in Alzheimer's disease and increases stroke risk, highlighting its critical impact on our ageing population. Endothelial cell dysfunction precedes other pathologies in both human SVD and preclinical models, where a causative deletion mutation and a single nucleotide polymorphism in the phospholipid flippase ATP11B were identified. However, the mechanism of action of ATP11B in SVD remains unclear. ATP11B is thought to mediate the translocation of phospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE) from the outer to the inner leaflet of plasmalemmal and intracellular vesicular organelle membranes. Both PS/PE contribute to membrane curvature and are essential for function of vesicular organelles. Single-nucleus transcriptome data from human SVD donors suggests involvement of lysosomal/autophagosomal pathways in SVD-affected endothelial cells, while loss of ATP11B disrupts membrane integrity, indicating that lipid changes drive SVD pathology. In PHOS-SVD, I hypothesize that loss of ATP11B alters the normal PS/PE lipid signature of endothelial cell membranes, altering lysosomal/autophagosomal function, promoting endothelial cell dysfunction and SVD pathology. Here, I will address 3 objectives in the Atp11bKO rat SVD model, with subsequent validation in human SVD tissue: 1) describe intracellular vesicular organelle function in endothelial cells in SVD, 2) determine PS/PE distribution in endothelial membranes and their action on intracellular vesicular organelle function and 3) examine if manipulation of lysosomal function and autophagy ameliorates endothelial dysfunction. PHOS-SVD interdisciplinary approach, integrating chemistry, super-resolution imaging and optogenetics, will advance our understanding on lipid membrane signature and its impact on SVD pathology. PHOS-SVD outcomes will help to develop future therapeutics to alleviate SVD burden.

Keywords: cerebral small vessel disease atp11b phospholipids lysosome autophagy
Discover the physiological and developmental functions of X chromosome dosage using new genetic and system models (XDose)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-07-01
End date: 2030-06-30
Duration (months): 60.0
Total project cost (EUR): 1983769.0
EU funding (EUR): 1983769.0
Participants: 1
Project status: SIGNED

Sex chromosomes are critical for controlling the phenotypic differences between males and females. However, they also create an imbalance in the gene products of sex-linked genes, with males having only one copy and females having two copies. To counteract this imbalance, many species evolved a chromosome-wide mechanism known as dosage compensation, which helps equalise gene expression between the sexes. This process is vital, as failed dosage compensation can lead to sex-specific disorders and lethality in several species including humans. Although researchers have made significant progress in understanding the mechanistic basis of dosage compensation, the core questions remain unanswered: why is the lack of X-chromosome compensation lethal and what are the physiological consequences of its absence? The proposed research aims to identify the mechanisms underlying X monosomy-associated lethality by studying the genes, cells, and developmental processes sensitive to X chromosome doses. This question has been poorly investigated partly due to the difficulties of studying sex chromosome effects. To overcome this barrier, we will investigate flies as these permit the remarkable possibility of generating mosaic animals where sex chromosomes can be genetically manipulated in defined organs, and consequently, functional and molecular analysis. Here, I will combine classical fly genetics, two novel model systems and cutting-edge genomic techniques to: 1. Identify the functions of X chromosome dosage in fly development. 2. Characterise the ancestral X chromosome compensatory system of all insects. 3. Discover the general shared functions of sex chromosome dosage in development using new insect model species. Thus, results from this research should have a major impact on our understanding of the importance of sex chromosome dosage in physiology and disease.

Keywords: sex chromosomes,sexual differentiation,dosage compensation