Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Partner Network for a Clinically Validated Multi-Analyte Lab-on-a-Chip Platform (PARCIVAL)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Netherlands,Germany,Romania,Netherlands,Germany,Germany,Germany,Switzerland,Germany
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-01-01
End date: 2014-12-31
Duration (months): 36.0
Total project cost (EUR): 4132600.0
EU funding (EUR): 2973550.0
Participants: 9
Project status: CLOSED

The objective of PARCIVAL is to develop an integrated and automated multi-analyte lab-on-a-disk platform for the fast and reliable sample in -> answer out diagnosis of highly infectious respiratory pathogens, resistance patterns and biomarkers for individual severity of the infection. The platform format will be based on completely integrated microfluidic foil-disposables. The disposables will feature different panels (selection of pathogens, resistance patterns, biomarkers), which can be freely selected and combined to allow a comprehensive choice of diagnostic parameters by the clinician at the point-of-care, vastly increasing the access to diagnostic information for doctors in everyday situations and emergencies. The integrated platform with pre-packaged liquid and dry reagents will automate all processing steps from sample preparation, over assay processing up to result reporting. This will allow evidence-based therapeutic decisions, allow antibiotic prescriptions which are tailored to the individual patient and thus offer the prospect to greatly improve therapeutic outcomes. Also, an air-sampling add-on module for monitoring of clinical ventilation systems will be developed and interfaced to the platform. By acting as early warning system that is able to identify airborne pathogens including resistances, this will increase the impact towards the topic 2.3.1-4 (“retard the development of multi-drug resistance”) as well as the area 2.3.1 (“development of effective infection prevention and control strategies”). The consortium consists of 9 partners (6 enterprises (4 SMEs), 3 institutes). The project is heavily based on the research capabilities of innovative SMEs. Therefore, SMEs will be the main beneficiaries of exploitation in the project. The key-developments of involved European SMEs will support European companies to establish a leading role in the field lab-on-a-chip applications which is based on the huge in vitro diagnostics market.

Keywords: integrated diagnostics,respiratory infections,multi-analyte testing,resistance testing,lab-on-a-chip
Loop models, integrability and combinatorics (LIC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Mathematical foundations
Countries involved: France
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-11-01
End date: 2016-10-31
Duration (months): 60.0
Total project cost (EUR): 840120.0
EU funding (EUR): 840120.0
Participants: 1
Project status: CLOSED

The purpose of this proposal is to investigate new connections which have emerged in the recent years between problems from statistical mechanics, namely two-dimensional exactly solvable models, and a variety of combinatorial problems, among which: the enumeration of plane partitions, alternating sign matrices and related objects; combinatorial properties of certain algebro-geometric objects such as orbital varieties or the Brauer loop scheme; or finally certain problems in free probability. One of the key methods that emerged in recent years is the use of quantum integrability and more precisely the quantum Knizhnik--Zamolodchikov equation, which itself is related to many deep results in representation theory. The fruitful interaction between all these ideas has led to many advances in the last few years, including proofs of some old conjectures but also completely new results. More specifically, loop models are a class of statistical models where the PI has made significant progress, in particular in relation to the so-called Razumov--Stroganov conjecture (now Cantini--Sportiello theorem). New directions that should be pursued include: further applications to enumerative combinatorics such as proofs of various open conjectures relating Alternating Sign Matrices, Plane Partitions and their symmetry classes; a full understanding of the quantum integrability of the Fully Packed Loop model, a specific loop model at the heart of the Razumov--Stroganov correspondence; a complete description of the Brauer loop scheme, including its defining equations, and of the underlying poset; the extension of the work on Di Francesco and Zinn-Justin on the loop model/6-vertex vertex relation to the case of the 8-vertex model (corresponding to elliptic solutions of the Yang--Baxter equation); the study of solvable tilings models, in relation to generalizations of the Littlewood--Richardson rule, and the determination of their limiting shapes.

Keywords: quantum integrability,representation theory,algebraic and enumerative combinatorics
Innovative strategies to generate human hepatocytes for treatment of metabolic Liver diseases: Tools for personalized cell therapy (INNOVALIV)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: France,United Kingdom,Spain,Sweden,Germany
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2011-12-01
End date: 2014-11-30
Duration (months): 36.0
Total project cost (EUR): 7682012.41
EU funding (EUR): 5884171.0
Participants: 7
Project status: CLOSED

Transplantation of donor hepatocytes has become an alternative to liver transplantation for the treatment of liver diseases. However, in addition to the complication imposed by severe shortage of donor livers, adult hepatocytes cannot be expanded in vitro. Autologous transplantation of genetically corrected hepatocytes represents another strategy as it circumvents the need for immunosuppression but this approach requires removal of 20% of the liver to isolate hepatocytes, which is not devoid of risks in patients with metabolic diseases. Therefore, there is a critical need to explore the potential human stem cells such as human Embryonic Stem (hES) cells to generate sufficient quantities of functional human hepatocytes. However, the production of safe and fully functional, human hepatocytes from hES cells under GMP conditions for clinical applications remains to be achieved. The general scientific objectives of this proposal are: - to develop scale-up procedures for hES cells and to produce GMP-grade tissue culture reagents that will facilitate large-scale differentiation of hES cells to hepatocytes. InnovaLiv aims to provide the EU healthcare system with a renewable and reliable source of functional clinical-grade hepatocytes generated from EU hES cells lines. Rigorous standards to ensure the safety and quality of these cells will be developed. The GMP-compliant hepatocytes will be prepared as a prototype therapy aiming at treating one patient on the basis of a compasive use protocol. - to provide proof-of-principle that defective hepatic function associated with inherited disorders (Familial Hypercholesterolemia, Hemophilia B, Crigler-Najjar) can be regenerated by correction of the deficiency in patient-specific iPS cells using integration-targeted lentiviral vectors to express the therapeutic cDNAs. Commercialization of novel products such as GMP-grade cells and cell culture tools will be performed by two partner SMEs that will assume leading roles in InnovaLiv.

Keywords: hepatocytes,liver diseases,pluripotent stem cells,regenerative medicine,clinical trials,therapeutic lentivectors
A Quantum Non-Demolition Microscope (QUANTUMPROBE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Fundamental constituents of matter
Countries involved: Germany
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-08-01
End date: 2016-07-31
Duration (months): 60.0
Total project cost (EUR): 1368600.0
EU funding (EUR): 1368600.0
Participants: 1
Project status: CLOSED

QuantumProbe will devise a novel microscope to probe and fully control the intriguing properties of quantum systems, formed by neutral atoms trapped in optical lattices. This includes in particular the possibility of in-depth quantum state characterization as well as engineering arbitrary quantum correlations. The microscope’s achievements will go far beyond standard state-of-the-art detection and manipulation capabilities in both, top-down approaches using large quantum gas systems, and bottom-up approaches with single particles. For this purpose, single or few well controlled neutral atoms will be immersed as “quantum-probes” into a quantum target system, a Mott-insulating state of another atomic species. Hence, QuantumProbe extends the concept of scanning microscopy to a single atom based coherent microscope, capable of parallel multi-tip operation with more than one probe atom. The fundamental measurement mechanism of this microscope is the entanglement between probe and target atoms, induced by coherent inter-species interaction, and subsequent detection of the probe atom’s state. QuantumProbe will thereby enable local, quantum non-demolition measurements of atom number or spin state as well as local, coherent manipulations such as spin flips and controlled-NOT quantum gates within the Mott-insulator. QuantumProbe will pave the way for break-throughs in various fields of research and practice: It will introduce local, fundamental quantum gates in scalable many-body systems, highly relevant for implementations of quantum information processing and quantum computing strategies; help elucidating the classification and quantification of multi-particle entanglement, which is even theoretically not fully clear; allow local coherent spin state engineering and read-out, opening the route for studies of quantum magnetism and related quantum simulations with single atom resolution; and devise tools for the studies of impurity physics in a well controlled environment.

Keywords: quantum gases,single neutral atoms,quantum non-demolition measurements
Optimisation of treatment with off-patent antimicrobial agents of ventilator-associated pneumonia (VAP) (MAGICBULLET)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Spain,France,Germany,Italy,Greece,Spain,Spain,Spain
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 7721719.0
EU funding (EUR): 5988018.0
Participants: 10
Project status: CLOSED

Background. Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-adquired infections, and multidrugresistant gram-negative bacilli (MDR-GNB) constitute the main etiology in many countries. Inappropriate empiric antimicrobial treatment is associated with increased mortality. In this context, the empirical treatment of choice for VAP is unknown. Colistin, and “old” drug, is now the antimicrobial with greatest in vitro activity against MDR-GNB. However, no randomized clinical trial with colistin has been carried out. Additional aspects of colistin are also not well known, such as the appearance of resistant strains or alterations in the intestinal microbiome during treatment. Furthermore, conventional microbiological techniques take 48 to 72 hours to identify pathogens and determine their susceptibility. This is too long if empiric treatment is inappropriate. Objetives. The overall goal is the optimisation of the treatment of VAP caused by MDR-GNB, by defining a gold standard empiric therapy and reducing the period of time needed for the determination of the etiology and susceptibility of pathogens. Methods. MagicBullet proposes a randomized, open label, multicenter, clinical trial to compare the safety and efficacy of colistin vs. meropenem, both combined with levofloxacin, for empirical treatment of VAP. The pharmacokinetic and pharmacodynamic characteristics of colistin will be determined. Evaluation of the impact of the both treatments in the intestinal microbiome of patients and in the Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-adquired infections, and multidrug-resistant gramnegative bacilli (MDR-GNB) constitute the main etiology in many countries. Inappropriate empiric antimicrobial treatment is associated with increased mortality. In this context, the empirical treatment of choice for VAP is unknown. Colistin, and “old” drug, is now the antimicrobial with greatest in vitro activity against MDR-GNB. However, no randomized clinical trial with colistin has been carried out. Additional aspects of colistin are also not well known, such as the appearance of resistant strains or alterations in the intestinal microbiome during treatment. Furthermore, conventional microbiological techniques take 48 to 72 hours to identify pathogens and determine their susceptibility. This is too long if empiric treatment is inappropriate.

Keywords: off-patent antibiotic,multidrug-resistant gramnegative bacilli,clinical trial,optimal treatment,ventilation associated pneumonia
Multi-level Embedded Closed-Loop Control System for Fluidic Active Flow Control Actuation Applied in High-Lift and High-Speed Aircraft Operations (ESTERA)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Poland,Poland
Call:  (SP1-JTI-CS-2010-04, 2010)
Start date: 2011-12-01
End date: 2013-04-30
Duration (months): 17.0
Total project cost (EUR): 249980.0
EU funding (EUR): 187470.0
Participants: 2
Project status: CLOSED

ESTERA project objective is to develop and deliver prototype of Closed-Loop Control System optimized for Active Flow Control actuation applied at the wing’s trailing edge or wing’s body and used for drag reduction / buffeting control in high-lift and high-speed aircraft operations. The project objective shall be achieved by: acquiring requirements imposed on CLC-System (particularly in terms of working conditions, wing geometry and sensors / actuators location), numerical simulations of air flow speed and pressure at wing surface (without and with working actuators) to define regulation goals (pressure values that shall be achieved) and to select the best control strategy, building system-under-control mathematical model, selection of control techniques to be tested (PID, LQR, adaptive, hybrid, others), definition of test cases and scope of tests, construction CLC-System Mock-up from already available parts, testing of selected control techniques on wing model in wind tunnel provided by Consortium and their iterative improvement / efficiency optimization due to test results with support of MATLAB tool (applying stochastic and evolutionary algorithms) and finally production and delivery of CLC-System prototype to SFWA. Multi–level distributed CLC-System is proposed, constructed of signal conditioning units embedded in sensors, sub-controllers embedded in actuators and main controller, connected in digital communication network (e.g. ARINC 429). This construction shall improve CLC-System efficiency by separation of tasks performed at high and low level as well as improve CLC-System reliability by independency of local sub-controllers. CLC-System Prototype shall be miniaturized using FPGA/CPLD technologies to be embedded in AFC actuators and sensors. CLC-System prototype shall be designed, developed, documented and tested (EMC & climatic tests) according to required standards (DO-160F, DO-178B, DO-254, EMC, etc.) to ensure possibility of obtainment of EASA certificate.

Keywords: active flow control,multi-level closed-loop control system,control algorithms optimization,fpga
Atmospheric Gas-Aerosol Interface: From Fundamental Theory to Global Effects (ATMOGAIN)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Earth system science
Countries involved: Sweden
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-09-01
End date: 2016-08-31
Duration (months): 60.0
Total project cost (EUR): 1498099.0
EU funding (EUR): 1498099.0
Participants: 1
Project status: CLOSED

Atmospheric aerosol particles are a major player in the earth system: they impact the climate by scattering and absorbing solar radiation, as well as regulating the properties of clouds. On regional scales aerosol particles are among the main pollutants deteriorating air quality. Capturing the impact of aerosols is one of the main challenges in understanding the driving forces behind changing climate and air quality. Atmospheric aerosol numbers are governed by the ultrafine (< 100 nm in diameter) particles. Most of these particles have been formed from atmospheric vapours, and their fate and impacts are governed by the mass transport processes between the gas and particulate phases. These transport processes are currently poorly understood. Correct representation of the aerosol growth/shrinkage by condensation/evaporation of atmospheric vapours is thus a prerequisite for capturing the evolution and impacts of aerosols. I propose to start a research group that will address the major current unknowns in atmospheric ultrafine particle growth and evaporation. First, we will develop a unified theoretical framework to describe the mass accommodation processes at aerosol surfaces, aiming to resolve the current ambiguity with respect to the uptake of atmospheric vapours by aerosols. Second, we will study the condensational properties of selected organic compounds and their mixtures. Organic compounds are known to contribute significantly to atmospheric aerosol growth, but the properties that govern their condensation, such as saturation vapour pressures and activities, are largely unknown. Third, we aim to resolve the gas and particulate phase processes that govern the growth of realistic atmospheric aerosol. Fourth, we will parameterize ultrafine aerosol growth, implement the parameterizations to chemical transport models, and quantify the impact of these condensation and evaporation processes on global and regional aerosol budgets.

Keywords: atmospheric aerosols,ultrafine aerosol growth,condensation,evaporation,organic aerosols
Probing fundamental properties of the neutrino at the SNO+ Experiment (NEUTRINOSNO+)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Fundamental constituents of matter
Countries involved: United Kingdom
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-11-01
End date: 2017-06-30
Duration (months): 68.0
Total project cost (EUR): 1345471.78
EU funding (EUR): 1345471.78
Participants: 1
Project status: CLOSED

I propose a comprehensive programme of research on SNO+, a multi-purpose neutrino experiment that has the capacity to push forward the frontier of our knowledge in both neutrino and solar physics by addressing a wide range of physics topics. There are three main goals: A) To extend our understanding of neutrino oscillations by studying the suppression of low energy solar electron neutrino flux components. B) To address discrepancies in solar models by publishing the world's first measurement of neutrino fluxes from the CNO-cycle interactions in the Sun. And C) To contribute to the search for neutrino-less double beta decay, the so-called 'golden channel' for testing the fundamental nature of the neutrino and the absolute neutrino mass scale. The neutrino survival probabilities and CNO spectra will be extracted simultaneously in a novel approach to the solar analysis that will capitalize on theoretical correlations between the different flux components. Similar techniques will be applied to the double beta analysis allowing for a fully correlated treatment of all backgrounds and systematic uncertainties. Given the huge potential impact of these measurements, it is imperative that we maximise the physics reach of the SNO+ experiment and ensure the credibility of all results through detailed calibration and modelling to attain a complete understanding of the detector response to both the neutrino signals and inevitable background contributions. In addition to the above analysis goals, this proposal focuses on two key areas - a detailed charcterisation of the detector optical response through calibration measurements and detailed simulations and the development of an electron calibration source to confirm our understanding of the detector response to electron signals across a broad energy range. Both of these unique contributions should significantly enhance the accuracy and credibility of all SNO+ physics measurements.

Keywords: neutrino oscillations solar modelling low background particle physics
Predicting Properties of Large Heterogeneous Systems with Optimally-Tuned Range-Separated Hybrid Functionals (PPOLAH)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physical and Analytical Chemical sciences
Countries involved: Israel
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-09-01
End date: 2016-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

I propose to develop a broadly applicable, quantitatively reliable, computationally simple approach to the study of large heterogeneous systems, and to apply it to important problems in molecular and organic electronics and photovoltaics. This will be based on a radically different approach to the development and application of density functional theory (DFT) - determining an optimally yet non-empirically tuned system-specific functional, instead of seeking a universally applicable one. Large heterogeneous systems are vital to several of the most burning challenges facing materials science. Perhaps most notably, this includes materials systems relevant for basic energy sciences, e.g., for photovoltaics or photocatalysis, but also includes, e.g., organic/inorganic interfaces that are crucial for molecular, organic, and hybrid organic/inorganic (opto)electronic systems. Theory and modelling of such systems face many challenges and would benefit greatly from accurate first principles calculations. However, the “work-horse” of such large-scale calculations – DFT – faces multiple, serious challenges when applied to such systems. This includes treating systems with components of different chemical nature, predicting energy level alignment, predicting charge transfer, handling weak interactions, and more. Solving all these problems within conventional DFT is extremely difficult, and even if at all possible the result will likely be too computationally complex for many applications. Instead, I propose a completely different strategy - sacrifice the quest for an all-purpose functional and focus on per-system physical criteria that can fix system-specific parameters without recourse to empiricism. The additional flexibility would help us gain tremendously in simplicity and applicability without loss of predictive power. I propose a practical scheme based on tunable range-separated hybrid functionals and a plan for its application to a wide range of practical systems.

Keywords: organic electronics,organic photovoltaics,density functional theory