Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unravelling Spatio-temporal Auxin Intracellular Redistribution for Morphogenesis (STARMORPH) (STARMORPH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Sweden,Czechia,Germany,United Kingdom
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-03-01
End date: 2031-02-28
Duration (months): 72.0
Total project cost (EUR): 10000000.0
EU funding (EUR): 10000000.0
Participants: 4
Project status: SIGNED

STARMORPH is a ground-breaking endeavour with the ambitious goal of understanding plant organ morphogenesis, which will pave the way to engineering plant growth. This is of paramount importance for enhancing agricultural and forestry yields and hence contributing to global food security and environmental sustainability. Plant organ morphogenesis involves differential growth, where various organ parts expand at different rates to create specific structures. A significant challenge lies in understanding these differential growth programs while considering the mechanical constraints imposed by the tissues. The plant hormone auxin plays a central role in differential growth. It forms concentration gradients within tissues, dictating the direction and rate of cell expansion. Mechanistically, auxin can either repress or promote growth in a tissue and concentration-dependent manner, but this biphasic behaviour remains largely unexplained. The extracellular space, cytosol, and nucleus have distinct auxin perception mechanisms and hence STARMORPH pitches an "auxin signature" concept, considering nuanced auxin levels in each compartment specifying an ensemble signal with quantitative and qualitative cell responses for morphogenesis. Currently, auxin subcellular compartmentalisation is poorly understood, and a key focus of the project is to provide a subcellular map of auxin dynamics within a growing organ to uncover how tissue mechanics interact with auxin-dependent growth processes, which will be pivotal for understanding plant morphogenesis. The STARMORPH project leverages a unique combination of plant, cell and synthetic biology, genetics, biophysics and organic chemistry expertise. This interdisciplinary collaboration aims to dissect plant morphogenesis from molecular to organ scales and has the potential to revolutionise our understanding of plant growth and development, with applications in biotechnology and plant engineering.

Keywords: morphogenesis,plants,auxin signature,cell wall,mechanochemical constraints,organelles,multiscale biology,hormone quantification,biosensor engineering,developmental plasticity,differential growth,signal integration,apical hook,interdisciplinary
Rethinking Water Security in an Urbanizing and Uncertain World (MOUNTAINWATERS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Water security is the key to protecting lives and livelihoods from the ravages of climate change. Very shortly, water management needs to undergo transformational, people-centred change with a focus on sustainability. Mountains are marginalized on many fronts — environmentally, politically and financially because of this communities have little or no access to reliable water supply and display low levels of water consumption. Springs are the primary source of water for many mountain communities. Due to urbanization, springs and their quality as well as access to them are changing. The biophysical and jurisdictional boundaries create a mismatch in terms of its management affecting the rights over it. The plethora of water suppliers and the roles they play in water provisioning suggests the need to ascertain the intertwining of the formal and informal. The study investigates the access to water in the face of climate change in the rural-urban continuum in the Himalayan Region in India. Through this study, I intend to create a framework that can be used to study water scenarios and work towards water security for urban mountain settlements. The objectives of this project are: 1. To understand the urban-rural continuum and the right to water 2. To assess women’s participation and roles in achieving water security 3. To appraise current and expected impacts of climate change on water security This work aims to close the methodological gap in carrying out and analyzing interdisciplinary studies on water. The work will add to the literature on water security under a changing climate. It will provide a unique case of the mountains which are marginalized geographies and most vulnerable to climate change. It will also provide methodological insights and help derive policy recommendations for mountainous regions of the world.

Keywords: water security himalaya mountainous landscapes rural urban continuum resource access springs institutions governance
The transcriptional regulation of cardiomyocyte polyploidization and its relevance in cardiac regeneration (REACTIVA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Spain
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The mammalian heart is a non-regenerative organ due to the extremely limited ability of fully differentiated cardiomyocytes (CMs) to proliferate. While neonatal hearts still contain mostly diploid CMs and regenerate efficiently, physiological postnatal CM polyploidization/hypertrophy ensures the contractile capacity of the adult myocardium but represents a roadblock to cardiac regeneration. Due to this limitation, diseases that provoke CM loss, like acute ischemia, frequently lead to heart failure. REACTIVA will establish a new strategy for heart regeneration based on the reactivation of a dormant endogenous mechanism, thereby achieving unprecedented advances in the field of cardiac regenerative biology. In mice, the proportion of adult diploid CMs (ADCs) correlates with regenerative ability, however, efforts to identify a molecular signature for ADCs have been unsuccessful, which has precluded exploring their roles in heart regeneration. Using an improved methodology for single-CM RNAseq, my group has identified a molecular signature of ADCs related to the fetal program and controlled by a single repressor transcription factor. This factor is specifically expressed in the polyploid CM population (PCM) and its inhibition in the postnatal mouse heart robustly increases ADC abundance and proliferative activity. Based on these findings, we propose that ADCs underlie a vestigial endogenous mechanism for adult mammalian heart renewal and that their stimulation will promote heart regeneration. REACTIVA will exploit our new findings on ADCs to 1) Fully characterize the ADC regulatory network, identifying factors to modulate it, 2) Identify and trace ADCs in the adult heart, defining their niches and contribution to renew and expand the CM population during heart homeostasis, aging and disease, 3) Use the generated knowledge to induce ADC activation with the goal of promoting adult mammalian heart regeneration.

Keywords: cardiac regeneration,transcription factors,gene therapy
A single electronic ship that establishes communications in an optimized way across different standards like 4G, 5G, IoT, and WiFi using AI enhanced features for more security and green impact (THE SMART RF CHIP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

A multi-standard & multi-band RF transceiver with an Artificial Intelligence based features, for configurable, secure, and green wireless communication systems. Transceivers (TRX) are chips that receive and demodulate Radiofrequency signals but also modulate and transmits them. It is the main working part of a Telecom/IoT equipment. Current transceivers are 100% hardware, and each is dedicated to a communication protocol and a specific spectrum band. We have developed a unique disruptive transceiver easily reconfigurable across multiple bands and multiples communication on one single chip (“software-defined radio”). It can also intelligently detect which channels are in use and which are not. On top of this, some AI-based features can improve the Quality of Service, reduce the energy consumption, and protect against cyberthreats. Our clients are chip manufacturers and OEMs, telecom operators, IOT devices manufacturers, satellite & aviation operators. The market is massive and driven by a fast growth of Telecom networks and IoT applications. Our innovation is unmatched in the market even with competition, as it consumes less energy, provides more agility and reduced time to market, and it is less costy. Our business model is flexible, either managing the chip production or licensing the IP. We are currently engaged in prototypes projects with Nokia, STMicroelectronics, and we target now to industrialize our innovation for a market entry.

Keywords: artifical intelligence,semiconductors,single chip,cyber security,european,chips design,innovation,patents,sorbonne,iot
Engaging the Value Of Living Labs to Innovate Care And Regulatory Environments (EVOLVE2CARE)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Greece,Belgium,Bulgaria,Spain,Cyprus
Call: Stimulating Experimentation Practices (HORIZON-EIE-2023-CONNECT-02, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 1220016.27
EU funding (EUR): 987230.14
Participants: 5
Project status: SIGNED

Charting a course for a more resilient and patient-centric healthcare future depends on continuous development and delivery of innovation to the market. EVOLVE2CARE focuses on HealthTech experimentation practice frameworks, standardizing and enhancing the symbiotic relationship between living labs and innovators in the context of the Transitional Care sector. Challenges ranging from an aging population to complexity of medical conditions and regulatory frameworks, bring a growing recognition of the importance of experimentation practices. By subjecting innovations to real-world scenarios, experimentation uncovers complexities, ethical considerations, interoperability challenges, and unforeseen barriers that controlled environments may not reveal. By harnessing the power of Living Labs – real-world environments involving users and stakeholders – EVOLVE2CARE will provide innovators with access to services for testing/validating research and products. EVOLVE2CARE focuses on three Use Cases (Hospital Discharge Management, Homecare Monitoring Solutions, Aging Population & Care Transitions), engaging stakeholders from across the value chain to examine complexities, barriers and enablers that regulatory frameworks pose to the development and commercialization of healthcare innovations. Recognizing the cross-disciplinary nature of healthcare, we will engage with EIT KICs and their beneficiaries. We will provide a scalable, collaborative experimentation space (the AccelUP marketplace), to aggregate Living Labs, innovators, researchers, regulators, investors, and other pertinent stakeholders. Trainings workshops, and reports will increase knowledge and disseminate findings to our stakeholders. The project partners encompass vast expertise and networks covering the development/commercialization of innovation in transitional care. The project advisory board consists of C-Level Experts in Healthcare/Pharma, Living Labs, Startups, EIT programs and Regulatory issues.

Keywords: experimentation practice frameworks,living labs,transitional care,healthtech innovations
The genomic consequences of domestication for ruminant pathogen evolution and herd diversity across ten millennia (HERDPATH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Ireland,France
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-03-01
End date: 2031-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: SIGNED

Palaeogenomics has transformed our understanding of the genetic consequences of domestication, particularly for livestock species, first brought into the anthropological sphere ~10,000 years ago in Southwest Asia. However, we know little of how domestication shaped the evolution and frequency of pathogens affecting livestock. Moreover, the evolution and occurrence of zoonoses - pathogens infecting both animals and humans - in Neolithic and later societies has been debated, but studies have focused on human remains to obtain ancient pathogen genomes, neglecting animal sources. HERDPATH will address this deficit through large-scale palaeogenomic screening of faunal remains from Eurasia across 10,000 years. Focusing on sheep and goats, two of our oldest domesticates and which share a high number of common diseases with humans, HERDPATH will analyse both pathogen and ruminant genomes to reveal the dynamic between ancestry, husbandry-induced inbreeding, immune gene variation, and pathogen occurrence through time. Bioinformatic screening will produce a temporal, multi-species archive of pathogen-positive livestock, providing the first molecular baseline of infectious disease presence in domestic herds. Time-stamped pathogen genomes will permit the timing of key evolutionary events such as host adaptation and the origin of lineages circulating today. Using data derived from multiple livestock species, HERDPATH will explore the co-evolutionary trajectory of pathogens and immune genes since domestication. Exploiting temporal genomes from underexplored sources will reveal how domestication shaped pathogen evolution towards increasing host adaptation, helping us to model the evolutionary dynamics of future livestock disease, zoonosis outbreaks, and food security. HERDPATH will be a step-change in our understanding of the consequences of domestication; how it drove pathogen evolution and the genetic makeup of our herds, shaped animal health, and our own health in return.

Keywords: goat genomics,sheep genomics,livestock pathogens,pathogen palaeogenomics,domestication palaeogenomics
Unravelling Biocontrol and Physiological challenges in pine wood NEMAtode pathosystem (BiPhyNEMA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Portugal
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-02-15
End date: 2025-02-14
Duration (months): 24.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 1
Project status: CLOSED

Pine Wilt Disease (PWD) caused by the nematode Bursaphelenchus xylophilus (Pine Wood Nematode, PWN) is one most devastating forest diseases worldwide. This pathology was detected in Europe in 1999 and future climatic scenarios point PWD will spread in the next decades threatening more than 60% of native range of Pinus sylvestris and P. pinaster. In parallel, adaptation of woodlands to Climate Change and its effect in tree defense against this pathology remain unclear. BiPhyNEMA will investigate how pines will react to those stress sources to better understand ecophysiological and pathogenic procedures that will drive their response in the middle term. The project has four research objectives: a) to evaluate physiological response of two P. pinaster genotypes (susceptible and resistant) infected by PWN under two different environmental conditions according to IPCC scenarios; b) to characterize functional response of infected seedlings and PWNs by dual-transcriptomics approach in the aforementioned scenarios; c) to monitor populations of PWN-mutualistic bacteria during nematode infection, and d) to investigate virus-based control potential using phages against PWN-associated bacteria. BiPhyNEMA combines transcriptomics with tree ecophysiology from an integrative point of view (ecophysiolomics) to achieve a holistic description of disease development. In addition, the project integrates that approach with pathology and applied virology, resulting in an original and interdisciplinary research with high potential for innovative findings. BiPhyNEMA provides a detailed personal career development plan focused in reinforcing autonomous research profile of the fellow. Moreover, the project will transfer new knowledge between forest researchers, foresters, and society using the most suitable means in each case. BiPhyNEMA adheres to key strategic orientations of Horizon Europe Program, and addresses the need to develop eco-friendly methods for forest protection

Keywords: bursaphelenchus xylophilus,pine wilt disease,climate change,forest resilience,phage therapy,ecophysiolomics,plant pathogen transcriptomics
Sub Sea Quieter, a disruptive, low cost and highly efficient Noise Mitigation System for reducing MRE installation noise and turbidity impacts on underwater ecosystems (SEALENCE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 3832967.75
EU funding (EUR): 2392687.5
Participants: 2
Project status: SIGNED

For offshore windfarms or coastal foundations, pile driving technique is often used. But it generates a high level of noise, which severly damages - up to death - marine mammals, fishes and other species. Noise Mitigation Systems (NMS) exist but with limits : high price, weak acoustic efficiency, bad behavior with current, waves and depth... To fill these gaps, we develop an innovative and eco-designed NMS : the SSQ® Pile Driving. It is based on the disruptive membrane Sub Sea Quieter® (inflatable panels of 3D-woven fabric, coated and sealed to insure acoustic efficiency) resulting from 5 years of R&D. Designed like a sock deployed closest and around the pile thanks to a clever manutention system, it aims at becoming the NMS technical reference by its very high acoustic mitigation efficiency, turbidity containment, its cost up to 5 to 10 times cheaper than existing NMS, with no any extra vessel or crane and its adaptability to the most severe site conditions (waves, curent, depth...).

Keywords: marine renewable energy,noise mitigation system
Disruptive Platform for advanced assessment and analysis of brain MRI studies powered by artificial intelligence (AI). (EDoNaDD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Poland
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

50 million individuals worldwide have a neurodegenerative disease, often resulting in dementia, a number expected to rise to 152 million by 2060. Moreover, 2.8 million people are affected by multiple sclerosis (MS). Early detection and treatment can help delay the progression of the disease. Our technology has the potential to revolutionise early diagnosis completely. Powered by AI, our MRI (brain) screening can detect a range of neurological diseases, including but not limited to Multiple Sclerosis (with emphasis on the progressive type differentiation and Double Inversion Recovery (DIR) sequence support), Alzheimer's (AD), Amyloid Related Imaging Abnormalities (ARIA), Atrophy, Aneurysm and more. At the heart of our solution are AI algorithms that generate reports with a comprehensive analysis of neuro-MRI studies. These reports include precise quantitative data on the volumetry of brain structures, allowing for tracking changes over time with particular attention to atrophy, vascular damage, and demyelinating changes. Through long-term insights, we assist in the early detection and monitoring of disease progression and the adjustment of personalised treatment plans for neurological disorders. Users will get the information on the fly in the automatically generated report accessible under its standard software PACS/RIS (integration with clinical/hospital software). The total estimated annual worldwide cost of dementia is over $1.3 trillion, and this figure is forecast to rise to $2.8 trillion by 2030. By supporting radiologists in fast and effective patient selection for treatment, we are potentially mitigating the high progression risk of various diseases. Moreover, our solution can be used during clinical studies with patients heading to new, effective drug development, having neurological diseases as the beginning of our mission.

Keywords: artificial intelligence,ai,brain mri,early detection,tracking,neurodegenerative diseases,demyelinating diseases,progressive multiple sclerosis,ms,wmh,alzheimer s ad,aria,atrophy,aneurysm