Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Functional role of the beta3-adrenoceptor in modulating the remodeling of the myocardium submitted to stress. (FRB3AR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-12-01
End date: 2014-11-30
Duration (months): 24.0
Total project cost (EUR): 169800.0
EU funding (EUR): 169800.0
Participants: 1
Project status: CLOSED

This project investigates the role of the beta3 adrenoceptor (β3-AR) in modulating the remodeling of the myocardium submitted to stress. Promising advances have been made in the host laboratory in showing that overexpression of the β3-AR in cardiac myocytes confers protection from pro-hypertrophic stimulus induced-remodeling. Preliminary data suggest that nitric oxide (NO) production by NO synthase (NOS), which is known to be coupled to the β3-AR signalling in the heart, is necessary for this protection to occur. Our central hypothesis therefore is that the activation of the β3-AR protects against hypertrophic remodeling of the heart through NOS and, possibly protein kinase G (PKG) -dependent mechanisms. The following stages of the research project will aim at 1) exploring the ability of the β3-AR to regulate remodeling in response to hemodynamic stresses of different severity; 2) ascertaining the specific role of the NOS isoform(s) in this protection; 3) unravelling the downstream effectors involved in the protective effects conferred by β3-AR activation; 4) investigating the co-localization of these key effectors with β3-AR in cellular microdomains, including caveolae; 5) studying the stage-specific- role of β3-AR signalling in the regulation of remodelling and function of stressed hearts from an inducible, cardiac specific, knockout mouse model. These experiments will enhance our understanding of the pathophysiologic role of beta3-adrenoceptors, which are upregulated in the remodeling heart, opening the way for new therapeutic modalities for cardiac remodeling using agonists at these receptors.

Keywords: health sciences,beta3 ar,nos,cardiac remodeling,cardiac specific,knockout mouse model,signalling pathway,protein kinase g,caveolae
Mechanisms of attentional modulation of neural responses in visual cortex of mice (RODATTN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-03-01
End date: 2014-02-28
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

This proposal aims to study the modulation of neural activity by attention in rodents, and its mechanisms. There has been substantial work done in this field using monkeys, which has revealed a number of interesting facts. However, these studies are limited in a number of ways. Firstly, there is a limit to the extent of invasive procedures that can be conducted in monkeys. Secondly, one cannot use molecular and genetic tools that have exploded in recent years in other model systems, in particular, optogenetics. The fundamental questions I will address in this proposal are: (i) What are the changes occurring in the brain when an animal switches its attention, and (ii) What are the mechanisms the brain uses to implement these changes? While work done primarily in primates has shed some light on the first question, very little is known about the second question. By addressing these questions in mice, I aim to take advantage of the powerful genetic tools available in this species to investigate the neural circuits underlying attention. I will train mice on a novel attention switching task, and optically record stimulus evoked calcium transients from multiple regions of the visual cortex at cellular resolution. I will compare the response to the same stimulus in attending and not attending conditions and I expect to find a difference due to attentional effects. I will further express Channel Rhodopsin in cholinergic neurons and excite the nerve terminals selectively in the visual cortex. In this manner I will test the hypothesis that elevated acetylcholine levels in the visual cortex can cause attention to shift and be maintained towards visual stimuli. This study will be relevant in the context of the European Commission's Europe 2020 strategy, since it will lead to innovation of novel techniques and synthesise multiple cutting edge research areas to result in an innovative research project, which will help in establishing the eminence of the ERA in the global scenario

Keywords: biological sciences,neuroscience,optogenetics,attention
miRNASTRESS: structural and functional study of the RBM38-controlled mechanism of mRNA stabilization. (MIRNASTRESS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-10-01
End date: 2014-09-30
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

The aim of the research activities detailed in this proposal is to understand how the RNA-binding protein RBM38 mediates the cellular stress response —the series of cellular events triggered by diverse harmful factors to restore cellular homeostasis— by modulating the activity of microRNAs on specific targets. Our objective is to determine the molecular mechanism by which RBM38 interferes with the binding of miRNAs on a selection of messenger RNAs that are targets of the tumor suppressor p53, a protein which guards the genomic integrity and regulates the stress response. The normal cellular stress response is crucial to restore or reprogram various gene-expression patterns that maintain homeostasis. Failure in this response can lead to severe pathological conditions, such as cancer. Understanding the mechanisms that mediate the stress response at the molecular level is thus one of the most important open questions in cell biology today and has a clear impact in molecular medicine and in the pharmaceutical industry. We will use state-of-the-art biophysical techniques to identify the molecular and biophysical basis of RNA recognition by RBM38. We will propose a mechanism to explain how RBM38 controls post-translational gene expression through the inhibition of miRNA activity. Our research will provide the molecular rationale for a key mechanism of cell regulation and will advance our knowledge of the biology involved in the development of cancer. miRNASTRESS will address a gene-regulation mechanism based on the interference of miRNA activity and will provide the necessary structural information to tune the activity of RBM38. Building on our study and on the know-how accumulated on RNA recognition motif-RNA interactions, we aim to use the RBM38 high-resolution structure as a protein template to develop small molecular weight compounds with therapeutic valence that interfere with the RBM38 biological function.

Keywords: molecular biology,biochemistry,biophysics,microrna,mrna,nmr spectroscopy,rna-binding proteins,protein structure,cancer,cellular stress response,p53,rbm38,post-translational gene regulation
Receptor competition for ligand: Stochastic modelling and cellular fate (VEGFR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-10-01
End date: 2017-01-31
Duration (months): 24.0
Total project cost (EUR): 209033.4
EU funding (EUR): 209033.4
Participants: 1
Project status: CLOSED

Vascular endothelial cells, that line blood vessels in mammals, make use of membrane-bound receptor molecules to bind extra-cellular molecules, such as growth factors, to regulate blood vessel development, new blood vessel sprouting, and vascular repair. While this vascular system is vital for the normal growth of tissue during development and wound-healing processes, it is also exploited by malign tumours through secretion of vascular endothelial growth factors that induce the growth of new blood vessels (angiogenesis), enhancing the perfusion of tumour mass. Moreover, imbalance in the regulation of this system has been linked to ocular and inflammatory disorders, ischaemic heart disease, neuro-degeneration, and other pathologies. This inter-disciplinary project aims to develop new stochastic mathematical models of the vascular endothelial growth factor receptor (VEGFR) and its binding to vascular endothelial growth factor, as well as receptor dimerisation, internalisation, signalling, trafficking, degradation, and subsequent regulation of endothelial cell fate. These models will be tested against experimental data obtained from the literature or generated within experiments to be designed and conducted during the execution of this project. The models will be constructed using a rule-based-modelling approach, analysed using Van Kampen’s system size expansion, and simulated using the Gillespie algorithm. Moreover, the models will be compared using a novel, sequential Monte-Carlo-sampling based Bayesian method that allows for the calculation of a posterior distribution over the models being compared, given the data. The insights derived from the analysis, simulation, validation and comparison of the stochastic models will advance our current understanding of the biology of the VEGFR receptor as one of the fundamental molecular mechanisms underlying blood vessel development, vascular repair and angiogenesis.

Keywords: biomathematics,stochastic processes applied to biology,receptor-ligand interaction,computational biology
Synthesis of molecular probes for cancer research based on priviliged natural products through a novel enantioselective oxidative arylation technology. (PYRROLOINDOLE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-09-01
End date: 2014-08-31
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

Enantioselective catalysis continues to be a necesarily expanding part of Organic Chemistry and Synthesis to be able to provide the enantiopure compounds that Society demands in a straightforward and sustainable way. This research proposal is aimed at doing so through the development of new enantioselective oxidative arylation reactions a completely unprecedented research field. Moreover, the molecular structures and synthetic targets have been selected in close collaboration with the group of Dr. Murrell at CRUK Cambridge. This collaboration is aimed at understanding the processes of cancer generation and growth at the molecular level through development of small molecule histone methylation and acetylation modulators. To study such processes a priviliged and synthetically challenging familiy of natural products is targeted: the pyrroloindole alkaloids. Development of molecular probes inspired by these products and demonstration of the total synthesis of some members will be accomplished through the development of appropiate chemical tools. The synthesis of these compounds will enable multidisciplinar research to study the particularities of oncogenesis.

Keywords: anticancer therapy,molecular genetics,carbon chemistry,homogeneous catalysis
Modeling the acquisition of phonotactics (MODACQUPHON)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-10-01
End date: 2015-09-30
Duration (months): 24.0
Total project cost (EUR): 191675.4
EU funding (EUR): 191675.4
Participants: 1
Project status: CLOSED

Children learn their target language early, fast and efficiently. For instance, nine-month-old infants already display knowledge of the phonotactics of their target language, namely have been shown to react differently to licit versus illicit sound combinations. Children must thus rely on a remarkably efficient phonotactic learning procedure. What does it look like? According to the error-driven learning model, the learner maintains a current hypothesis of the target adult phonotactics and keeps slightly updating its current hypothesis whenever it makes a mistake on the incoming stream of data from the adult language, until it makes no more mistakes. This learning model is very popular in the current acquisition literature because of its cognitive plausibility: it models the observed acquisition gradualness, as it describes a stepwise progression towards the target adult grammar; it relies on surface phonology, without requiring any knowledge of morphology (that plausibly develops later than phonotactics); and it does not impose unrealistic memory requirements, as it only looks at a piece of data at the time without keeping track of previously seen data. Yet, computational phonology has failed so far to develop a computationally sound implementation of the error-driven learning model. This project aims at filling this gap. Two complementary directions are pursued. An analytical direction geared towards learnability uses tools from Machine Learning to investigate the computational efficiency of the error-driven learning model, focusing on issues such as convergence, correctness, error bounds, and robustness. This analytical strategy is complemented by large scale simulations, that test the model on a large database of infant-directed speech and child acquisition data. Combining a computational perspective focused on learnability with a modeling perspective based on acquisition data will allow my project to break new ground in child language acquisition.

Keywords: phonotactics,learnability,child acquisition,optimality theory,modeling
De-coding European Foreign Policy from the Outside. Views from the Maghreb Periphery (EU-MED INSIGHTS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-09-01
End date: 2016-03-10
Duration (months): 24.0
Total project cost (EUR): 174475.2
EU funding (EUR): 174475.2
Participants: 1
Project status: CLOSED

This research project explores the gaps between how the EU understands and presents itself to the world and how Others’ in the EU’s southern periphery perceive its role in the two challenging fields of democratisation and development. The project is grounded on the literatures on European foreign policy, democratization and development. It fills the gap linking these three broad areas of research. Moreover, it is related to the EU’s aspirations to contribute to development and democratization processes in its turbulent neighbourhood. With the Lisbon treaty, a lively debate has ensued on how the EU can exert any meaningful influence in increasingly interconnected, non- Western and heterogeneous environment while it remains divided on all major issues of foreign policy. What is at stake is indeed a complete change in the way relations of power are recognized and calculated within the EU external relations. Taking such path is not easy, but it is becoming clear that inward looking and hesitant Europe is no longer an option – unless Europe is prepared to accept its own decline in world politics. With that theoretical background the overall objective is to investigate how the Arab-Mediterranean periphery is responding to and shaping EU external policy, and in return is responding to and managing its own processes of socio-economic and political transformations. In the interests of defining a viable and manageable research project, the focus on the EU’s democratization and development discourses and practices towards three Mediterranean neighbours: Morocco, Algeria and Tunisia.

Keywords: social sciences,european foreign policy,development,democratisation,mediterranean region
Development of radiation sensors based on stacked RADFET technology (NEWRADSENS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-09-01
End date: 2013-08-31
Duration (months): 12.0
Total project cost (EUR): 133361.3
EU funding (EUR): 133361.3
Participants: 1
Project status: CLOSED

Tyndall National Institute is a world leader in research, development, and commercialisation of Radiation Field Effect Transistor (RADFET) technology. RADFET is essentially a p-channel MOSFET optimised for radiation sensing. We have developed the RADFETs for applications in space, high energy physics laboratories, and radiotherapy clinics. The promising application/market segment of personal dosimetry is currently out of reach of standard RADFET technology owing to its insufficient sensitivity for this application. However, we have recently developed a so called “stacked RADFET” concept which increases the sensitivity of a standard technology by 2-3 orders of magnitude and potentially brings it to the ranges required in personal dosimetry. We have recently completed the preparatory work and secured funding to actively pursue this topic starting from early 2012. Tyndall would greatly benefit from additional experienced researcher working on the crucial aspects of a dedicated stacked RADFET development project. We have identified a researcher with the ideal background to perform this work and in the process receive training and enhance his experience in the multidisciplinary set of skills, including fabrication process/device simulations, semiconductor manufacturing, electrical characterisation techniques for the RADFETs, analysis of basic mechanisms of radiation-induced defects, and administrative/technical management of the EU projects.

Keywords: radiation sensor,radfet,mosfet dosimeter,personal dosimetry
The evolution of cancer in ageing societies: An international perspective (CAN-EVOLUTION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-05-01
End date: 2014-04-30
Duration (months): 24.0
Total project cost (EUR): 201932.4
EU funding (EUR): 201932.4
Participants: 1
Project status: CLOSED

This project is a training-through-research project that aims to describe the global evolution of cancer in the ageing societies using international comparison studies. Three theories have been proposed to explain the dynamics of ageing populations: compression of morbidity, expansion of morbidity, and dynamic equilibrium. Yet, these theories have never been applied to understand the evolution of cancer, a disease that occurs primarily at old age. Using global databases, I will assess the population impact of changes in longevity and duration of morbidity among patients with cancer. I hypothesize that increases in life expectancy after cancer diagnosis have primarily led to expansion (longer time spent with disease before death) rather than compression of years lived with illness and disability. Life table analysis weighted for severity of cancer types to derive disability-adjusted life expectancy will be used to assess the evolution of cancer in ageing societies. This is the first study to apply the dynamics of aging population theories to unravel how cohort of cancer patients can be expected to evolve after survival. The study will also provide an important base for applying these theories in the aging theories in general and to solve health care issues pertinent to this frail population. Parallel to the scientific activities aimed to describe the dynamic of ageing among cancer patients, this project will provide various training opportunities to increase my competence in analysing large databases, in communication and teaching, in writing scientific articles and it will also substantially increase my collaborative network. The combination of renowned scholars with the available resources and access to international networks makes the host institution (International Agency for Research on Cancer) the best place to spend a mobility period to carry on this project. It will also significantly benefit my future career development.

Keywords: oncology,demography,epidemiology
Tau Toolkit for opening the New Physics Window at LHC and possible spin off effects (TAUKITFORNEWPHYSICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-07-01
End date: 2014-06-30
Duration (months): 24.0
Total project cost (EUR): 193594.8
EU funding (EUR): 193594.8
Participants: 1
Project status: CLOSED

The applicant, from Seoul National University proposes to develop novel tools and research strategies for exploring the physics beyond the Standard Model (BSM), at the LHC at CERN, by taking part to the CMS multipurpose experiment from 2012 to 2014. This exciting period will witness a new major step in the LHC program and BSM exploration, with important Physics results from the 5 -10 fb-1 recorded data and the LHC reaching highest luminosity and preparing for doubling energy. This project takes all these facts into account and aims to develop a “toolkit” based on Physics studies, related software tools development and detector R&D aspects to optimize the extraction of New Physics in these worsened conditions. By observing that the tau is a key component and the top production a reference process in the study of the BSM signatures, this project will develop tools for improving the selection of New Physics signatures from the increasing huge backgrounds and pile up events The toolkit comprises i) new highly performing software tools, fully exploiting the tracking information ii) inserting them at high level trigger, iii) contributing then to the exploratory studies to include the tracking at the first level trigger, iv) and participating to launch the R&D on a new generation of Silicon trackers and associated readout electronics. Integrating the tracking in the trigger is the main experimental challenge at LHC in this decade; it will request novel developments on various aspects of the semiconductor technology. The CMS part will be done in association with the Pisa CMS group, based on long term collaboration with the researcher in charge at the Tevatron. The R&D on advanced Silicon technology will be performed in the host Institution. This special twofold framework will optimize the chances of success by combining high and complementary expertise with important benefits for Europe and Korea in the long range.

Keywords: particle physics,lhc,cms,tau lepton,top factory,new physics,tracking trigger,novel silicon technology