Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Collaborative development of renewable/thermally driven and storage-integrated cooling technologies (CO-COOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Germany,Italy,Egypt,Singapore,China,Thailand,United States,United Kingdom,Canada,Chile,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-10-01
End date: 2025-09-30
Duration (months): 48.0
Total project cost (EUR): 892400.0
EU funding (EUR): 639400.0
Participants: 17
Project status: SIGNED

Cooling is the fastest-growing use of energy in buildings but is also one of the most critical blind spots in today’s energy debate. Rising demand for space cooling is putting enormous strain on electricity systems in many countries, as well as driving up emissions. Comparing to heat, power, and transport, cooling had long been under-represented in the EU energy policy until 2016 when the European Commission took the first step with the launch of its Heating and Cooling Strategy. The strategy identifies actions of ‘increasing the share of renewables’ and ‘reuse of energy waste from industry’ as two key areas for decarbonizing cooling to meet the EU’s climate goals by 2050. Accordingly, the targets are only achievable with fast development and deployment of new efficient and effective cooling technologies driven by either ‘renewable electricity/heat’ or waste heat. This CO-COOL RISE project assembles an international, interdisciplinary consortium from 12 research institutions and 5 industrial companies to collectively accelerate the cooling technology development and deployment, with complementary expertise/skills including composite solids, phase change materials (PCMs), complex fluids, process intensification (heat and mass transfer), cold thermal storage, refrigeration systems, as well as techno-economic analysis (TEA) and life cycle assessment (LCA), marketing analysis, and entrepreneurship skills. Based on the innovation of composite solids (sorbents/PCMs) and fluids (PCMs and hydrate slurries) as well as related components and systems, the project aims to develop renewable/recoverable energy driven, storage-integrated cooling technologies which could offer energy resource-efficient and cost-effective solutions to meet end-users’ low carbon cooling demand.

Keywords: adsorption cooling systems,cold thermal energy storage,refrigeration engineering,waste heat recovery
Renormalisation Group methods for discrete Quantum Gravity (RGDQG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Understanding quantum gravity requires us to bridge a large gap of scales. The fundamental theory we are searching for is a theory of spacetime at the shortest distances and highest energies. There are many competing proposals for what type of structure best describes this regime. We can not currently generate these high energies in the lab, and hence the most likely method of observing quantum gravity effects are large scale, i.e. astronomical and cosmological observations. To make phenomenological predictions for these large structures, from short scale quantum gravity models, we need to use a renormalisation procedure. In solid state physics, it is common to use real space renormalisation, in which systems at different sizes are directly related. An example of this is block spin renormalisation of the Ising model, by summarising several spins into one block the system is rescaled, leading to an effective description at larger scales. Applying a similar blocking renormalisation to discrete theories of quantum gravity can help us understand their scaling behaviour. This scaling behaviour can then be used to generalise from small scale simulations to larger scale structures, and to identify universal characteristics arising in these models. I have much experience in working with discrete gravity systems, using both analytic and computational methods, which the research and training covered in this proposal will allow me to extend. The host institution, Radboud University in Nijmegen, was chosen for the excellent quality of research. The quantum gravity group led by Professor Loll will provide expert advice, and the strong program of visitors will further enrich the project. The mathematical physics group is comprised of experts in the field of non-commutative geometry, and the proposed research will strengthen the interdisciplinary ties between these groups.

Keywords: renormalisation group,discrete gravity,quantum gravity,non commutative geometry,causal dynamical triangulations,causal set theory
A multifunctional self-immolative hydrogel for accelerating the healing of chronic wounds (Multi-SIP Hydrogel)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-01
End date: 2019-01-31
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

In this Marie Skłodowska-Curie Fellowship project entitled “Multi-SIP Hydrogel” I will design a modular synthetic platform for preparing multifunctional self-immolative polymer (SIP) hydrogels designed to accelerate tissue regeneration in chronic skin wounds. The hydrogels will contain multiple SIP components, each designed to rapidly degrade and deliver a therapeutic payload in response to a specific biochemical stimulus typical of a chronic wound (e.g., reactive oxygen species or enzymatic action). During the two years of this Fellowship, I aim to establish a proof-of-principle SIP-hydrogel system that will undergo sequential stimuli-responsive degradation and promote cell proliferation in vitro. This Fellowship will be undertaken under the supervision of Prof. Molly Stevens in the Division of Biomaterials and Regenerative Medicine at the Karolinska Institute (KI), which has the world-leading expertise in polymer chemistry, biomaterials engineering, cell biology and tissue engineering crucial to the objectives of the proposed work plan. Due to the modular design of the "Multi-SIP Hydrogel" platform, there is broad scope for designing SIP-hydrogels matched to different tissue types once a proof-of-principle is established. This will initiate new research areas at the cutting edge of biomaterials science, which will help me to establish my own independent research career following the proposed Fellowship.

Keywords: dynamic hydrogels,self immolative polymers,stimuli responsive materials,live cell raman microspectroscopy
New Buildings Energy Renovation Business Models incorporating dual energy services (NOVICE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Germany,Ireland,Spain,Austria,Spain,Italy,Finland,Greece,United Kingdom
Call: Development and roll-out of innovative energy efficiency services (H2020-EE-2016-CSA, 2016)
Start date: 2017-06-01
End date: 2020-05-31
Duration (months): 36.0
Total project cost (EUR): 2041206.25
EU funding (EUR): 2041206.25
Participants: 10
Project status: CLOSED

NOVICE will develop and demonstrate a new business model in building renovation to better monetize energy efficiency by consolidating services and subsequent revenue streams from both energy savings and demand response. In order to do so NOVICE introduces new actors (aggregators) in building energy upgrade projects and fosters their collaboration with ESCOs, financing institutions, facilities management companies, engineering consultants to facilitate the roll out of the dual (grid services and energy efficiency) energy services model. The main business bond to be forged between ESCOs and Aggregators through NOVICE will allow their seamless collaboration in exploiting economies of scope and scale along with risk sharing on implementing building energy renovations. That business relationship will take the form of a MoU and will result in the composition of a new enhanced EPC template that can deliver the successful deployment of the dual energy services scheme in building renovation. The enhanced EPC template and the overall dual energy services scheme will be scrutinized by a financing institution to assess its bankability and identify the appropriate financing mechanisms for initiating and rolling out investments under that scheme. NOVICE throughout its duration targets to trigger the initiation of more than 20.8 m EUR of investments in building renovation based on the dual energy services model that will result in primary energy savings of more than 25.2 GWh/year. To achieve that target NOVICE brings together a highly experienced consortium that consists of stakeholders from the entire value chain (research institutions, technology vendors, engineering consultants and facilitators, Aggregators, ESCOs, Financing institutions, Facilities Management companies) of building renovation. Strong participation of SMEs (6 out 9 partners) demonstrate the commercial exploitation potential of the NOVICE outputs and supports the successful rollout of the NOVICE business model.

Keywords: energy efficiency,demand response,esco,aggregator,building renovation,business model,dual energy services,financing,monetisation
A new biosynthesis procedure for pharmaceutically active gamma-aminobutyric acids (SynBioGABA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-07-01
End date: 2017-09-30
Duration (months): 15.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Chiral γ-aminobutyric acids (GABAs) represent abundantly prescribed drugs, which are broadly applied as anticonvulsants, antidepressants and for the treatment of neuropathic pain. With the incorporation of more population to western-based style in the coming decades, there is a need of developing and producing pharmaceutically active GABAs and similar (or generic) drugs for higher number of consumers. Supported by an ERC starting grant, Prof. Poelarends has developed an efficient, enzyme-based procedure for the enantioselective synthesis of a wide variety of GABAs. The PoC grant will allow Prof. Poelarends to identify those opportunities in the huge pharmaceutical/generics market where his novel synthesis procedure for pharmaceutically active GABAs provides unique advantages over existing industrial synthesis strategies, in terms of performance, sustainability and economics. To enable the next step towards commercialization, a strong and commercially attractive IP position will be built and a portfolio will be assembled in which the performance of the new technology is compared to current industrial production strategies using extensive market research and demonstration studies. Ultimately, the hope is to license our technology to existing pharmaceutical/generics companies.

Keywords: biocatalysis,biosynthesis,enzymatic cascade,artificial metabolism,pharmaceuticals,drugs,gaba,gamma aminobutyric acid
A motivic circle method (MotivicCircleMethod)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-01
End date: 2022-10-24
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: CLOSED

The Hardy-Littlewood circle method is a well-known technique coming from analytic number theory, which has been very successful, throughout the last century, in solving many major number-theoretic problems, among which the ternary Goldbach conjecture. In recent years, it has proven even more versatile, finding several applications beyond number theory, for example in quantum computing and algebraic geometry. The aim of this proposal is to adapt the circle method to the so-called motivic setting and apply it to a range of geometric problems. The possibility of a motivic circle method has been raised as an open question by several renowned researchers, as an increasing number of mathematicians are becoming interested in motivic methods because of their numerous applications to other areas of mathematics. The goal is to create a clear and convenient setup for the motivic circle method accessible to mathematicians less used to the motivic setting, highlighting the analogies with the usual circle method. The proposed applications concern spaces of rational curves on hypersurfaces. Describing such spaces is of interest in theoretical physics and is a very active field of study in mathematics, as understanding their structure can shed light on several major open questions in algebraic geometry and number theory. The candidate plans to carry out a thorough investigation of the geometry of such spaces using the motivic circle method, greatly generalising previous results. This will initiate a systematic approach to the study of spaces of rational curves in the motivic framework, and will in particular extend previous work by the proposed supervisor Prof. Tim Browning and his coauthors. The choice of supervisor and host institution is a natural one: while the proposed supervisor Prof. Tim Browning is a leading expert of the circle method, the candidate is very experienced with the motivic setting, and both have previously worked with spaces of rational curves.

Keywords: circle method,spaces of rational curves,grothendieck ring of varieties,motivic integration,cubic fourfolds,k3 surfaces
REE4EU: integrated high temperature electrolysis (HTE) and Ion Liquid Extraction (ILE) for a strong and independent European Rare Earth Elements Supply Chain (REE4EU)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Germany,Italy,Spain,Spain,Belgium,Norway,Sweden,Norway,Belgium,France,France,France,France,United Kingdom
Call: Recovery technologies for metals and other minerals (H2020-SPIRE-2015, 2015)
Start date: 2015-10-01
End date: 2019-09-30
Duration (months): 48.0
Total project cost (EUR): 9063772.5
EU funding (EUR): 7522490.63
Participants: 19
Project status: CLOSED

The REE4EU project will develop, validate and demonstrate in 2 industrially relevant Pilots an innovative Rare Earth Alloys (REA) production route from Permanent Magnets (PM) and Secondary Batteries (SB) waste. Currently only 1% of RE waste is being recovered as no adequate process is available, so proof-of-concept in REE4EU will open-up a fully new route bringing recovery of 90% of in-process wastes from PM manufacturing within reach. The targeted integrated solution is based on recently developed lab-proven technologies for direct high-temperature electrolyses of REA production. It will be combined in the pilots with an innovative and proven Ionic Liquid Extraction or tailored hydrometallurgical pre-treatment to demonstrate dramatic improvements in cost and environmental performance compared to state of the art technologies. This includes avoidance of process steps (pure RE extraction and reprocessing), 50% energy savings, and 100% recycling of ionic liquids as opposed to disposal of strong acid leeching agents in state of the art pre-treatment steps. The project involves in its consortium the full value chain including (SME and large) RE metal producers, PM manufacturer, SME process engineering companies and LCA experts, (SME and large) electronics and battery recycling companies, SME technology transfer, innovation specialists as well as chemical and end-user associations. Together with 4 top research institutes on electrolyses, ionic liquids and RE recycling, they will prove technical and economic viability on in-process PM waste (swarf), as well as End-of-Life (EoL) PM and SB waste, develop urgently required market data on EoL RE availability and a triple value-chain business case for a new European secondary Rare Earth Alloys (REA) production sector, creating new jobs, increasing Europe’s independence from imports and providing valuable raw materials for fast growing European green-technology industries such as Electrical/Hybrid vehicles and Wind Turbines.

Keywords: critical raw materials,rare earth metals,process resource efficiency,supply chain security
A Biophysical Investigation of the Duality in Fas Receptor (Fas_Life-Death)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Membrane receptors control fundamental physiological processes in cells, and are major targets of medical drugs. The goal of this project is to investigate the nanoscale motion of the membrane receptor Fas and its functional role in maintaining immune surveillance. Fas is ubiquitously expressed in human body and has significant roles in disease progressions. A type I single pass transmembrane protein, Fas is known for its ‘dual character’ in triggering signaling pathways leading to both cell survival and cell death. In the presence of its ligand, the receptor undergoes higher-order clustering to form a death-inducing signaling complex (DISC) in the intracellular region. Immune cells use Fas-mediated DISC formation as a mechanism to ‘kill’ virus infected or malignant cells. The Fas ligand, which is a type II transmembrane protein, can be cleaved which results in its soluble variant. Unlike the membrane anchored Fas ligand, the cleaved variant is known to induce an alternative motility inducing signaling complex (MISC) in Fas receptor that results in cell migration. Although the functions of the Fas receptor (and the notion of duality) are well established, how it selects for non-apoptotic or apoptotic pathways is an open question. It has been postulated that the membrane bound and cleaved variants of the Fas ligand induce different structural orientation and conformations in the intracellular domains of the receptors to control DISC/MISC formation. However, due to the immediate higher order aggregations upon ligand-binding and the presence of other modulating proteins during in-vivo experiments, it has been a great challenge to test this hypothesis. This project will investigate the biophysical mechanism behind the duality in full-length Fas receptors by exploiting single-molecule Förster resonance energy transfer (smFRET) and membrane nanodisc platform. Mechanistic understanding of Fas transmembrane signaling has both scientific and pharmaceutical significance.

Keywords: smfret,membrane receptors,nanodiscs
Financial and Institutional Reforms for the Entrepreneurial Society (FIRES)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Belgium,Greece,Hungary,Sweden,Netherlands,United Kingdom,Portugal
Call: The European growth agenda (H2020-EURO-SOCIETY-2014, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 2544641.0
EU funding (EUR): 2544641.0
Participants: 9
Project status: CLOSED

In this project we will analyse the broader contexts of smart, inclusive and sustainable growth in Europe to support implementation of the Commission’s 'Europe 2020' growth strategy and to restore Europe’s ability to innovate, grow and create jobs over the coming decades. In this proposal we argue that entrepreneurship must play a central role in that effort. 'Entrepreneurship' tends to make people think of the US and its model of high growth and high-tech start-ups in Silicon Valley. We are keenly aware, however, that a European growth agenda requires a focus on European entrepreneurship. US recipes and models will not fit the European context and do not deliver the results Europe wants. Our project's objective is therefore to thoroughly analyse European institutional arrangements and their current (in)ability to mobilise Europe’s human, financial and knowledge resources for entrepreneurial activity. This will help us formulate an effective reform strategy to reinvigorate European economies. The current diversity of institutional arrangements in Europe has long and common historical roots that must first be recognised and understood. Based on common global trends in technology and competition, we then establish the urgency and desirability for making the transition to a more entrepreneurial economy throughout Europe. Once this has been established, our project will develop and provide the tools for policy makers to assess the quality of national and regional entrepreneurial ecosystems and to identify the main strengths and weaknesses with regard to making the transition. Based on this assessment we will formulate specific proposals to enhance the allocation of talent, finance and knowledge to new value creation and we will conclude our project with a legal analysis to see where competencies currently lie and what action could be taken.

Keywords: institutional economics