Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Glycolytic contribution to cancer growth and metastasis (TUMETABO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physiology, Pathophysiology and Endocrinology
Countries involved: Belgium
Call:  (ERC-2009-StG, 2009)
Start date: 2009-12-01
End date: 2014-11-30
Duration (months): 60.0
Total project cost (EUR): 1493320.0
EU funding (EUR): 1493320.0
Participants: 1
Project status: CLOSED

Cancer lethality is most often associated to occurrence of distant metastases. To grow and become aggressive, cancers may undergo 2 critical adaptations: the glycolytic switch, corresponding to uncoupling glycolysis from the tricarboxylic acid (TCA) cycle, and the angiogenic switch, promoting neovascularization. In this high risk/high gain research program, we propose that the glycolytic switch precedes and promotes angiogenesis and metastatic dissemination in most types of cancer. We further envision that lactate, the end product of glycolysis, interfaces glycolysis and the latter processes through activation of hypoxia-inducible factor HIF-1. A thorough characterization of the molecular pathway(s) initiated by lactate (using transcriptomic, gene silencing, enzymatic and pharmacological interventions) has the potential to unravel new therapeutic targets that would simultaneously inhibit the consequences of the glycolytic switch on cancer aggressiveness. We anticipate the plasma membrane lactate transporters of the (sodium) monocarboxylate transporter (S)MCT family to be key determinants of autocrine and paracrine lactate signaling in cancer. Modulation of their activity or expression (notably by the generation of (S)MCT knock out mice) could thus profoundly affect tumor angiogenesis and metastasis. Since hypoxia is a hallmark of cancer and glycolysis its direct consequence in cancer cells surviving to hypoxia, the findings could have important consequences for the treatment of virtually all types of cancers. It could also impact our understanding of other pathologies, such as wound healing and heart infarction, in which the interplay between glycolysis, HIF-1 activation and angiogenesis could play a critical role.

Keywords: cancer,hypoxia,hif-1,metabolism,glycolysis,angiogenesis,metastasis,wound healing.
ATP dependent nucleosome remodelling - Single molecule studies and super-resolution microscopy (REMODELLING)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: Germany,Germany
Call:  (ERC-2009-StG, 2009)
Start date: 2009-11-01
End date: 2014-10-31
Duration (months): 60.0
Total project cost (EUR): 1395381.0
EU funding (EUR): 1395381.0
Participants: 2
Project status: CLOSED

In eukaryotic cells the DNA is packaged into nucleosomes and higher order structures which lead to a condensation and protection of the DNA. During important cellular processes such as transcription or replication access to the DNA has to be granted. This is facilitated by ATP dependent nucleosome remodelling. The mechanistic details how the involved remodelling complexes succeed in providing access to the nucleosomal DNA are currently in spite of large experimental efforts not well understood. The aim of the proposal is to unravel the molecular mechanism of nucleosome remodelling using single-molecule fluorescence resonance energy transfer (FRET). By putting labels on the nucleosomal DNA, the histones or the remodellers we will - step by step - determine the conformational changes that occur during remodelling and use this information to build a mechanistic model. We will also use the controlled assembly of 30 nm fibers from purified components in order to determine how remodelling occurs in this structurally restricted environment. The large size of the chromatin fibers will dictate that in addition to FRET measurements, which will again be used to investigate local motion, super-resolution microscopy need to be employed to obtain information about long-distance movements. To this end we will use stochastic optical reconstruction microscopy (STORM), which allows for accuracy below 10 nm, thus ideally complementing the FRET approach. In summary our experiments will lead us to a mechanistic understanding of ATP dependent nucleosome remodelling, both on mono-nucleosomes as well as in higher order structures. This knowledge will in return stimulate new initiatives aimed at understanding the nature and regulation of chromatin dynamics in vivo.

Keywords: chromatin,remodelling,single-molecule,fret,fluorescence,storm,sted,molecular motor,dna,live cell imaging
From neurons to behavior: analysis of the mechanisms underlying sensory coding and plasticity in chemical senses (NEUROCHEMS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: Switzerland
Call:  (ERC-2009-StG, 2009)
Start date: 2009-12-01
End date: 2014-11-30
Duration (months): 60.0
Total project cost (EUR): 1399998.0
EU funding (EUR): 1399998.0
Participants: 1
Project status: CLOSED

How sensory processing is occurring into the brain and how to relate behavior to neuronal activities are key questions in modern neuroscience. Understanding the neural codes underlying brain function will be of great importance for future implementation of brain-machine interfaces. This research project proposes to study the cellular and network mechanisms controlling sensory perception. In particular, we would like to precise how sensory stimuli are coded by brain networks and how these representations may be influenced by experience or modulatory brain centers. In order to address these general questions, we propose to study olfaction as model sensory system. The olfactory system is central to the behavior of rodents (animal models that we study), is highly plastic and largely modulated by the neuromodulatory brain centers. We propose to use a combination of genetic, electrophysiological, imaging and behavioral methods to study how odor information is processed in the central nervous system as it moves from the periphery to higher areas of the brain. We showed in the past that sensory information can be contained in dynamic neural ensemble. We propose to show that ensemble dynamics may be the basis of odor coding in the olfactory bulb and to describe the mechanisms underlying cortical coding that would allow us to relate neuronal activity to behavior. In addition, we hope to show the existence of a novel form of plasticity in the olfactory bulb namely ensemble plasticity. We believe that the general questions addressed in the study of these sensory systems go beyond understanding olfactory sensory perception and could potentially be generalized to the function of many brain regions.

Keywords: olfaction,sensory coding,plasticity,neural ensembles,network connectivity and dynamics
IMproving Occupational Safety & Health in European SMEs with help of simulatION and Virtual Reality (IMOSHION)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SME associations
Action type: Research for the benefit of specific groups
Countries involved: Germany,United Kingdom,Germany,France,Netherlands,Germany,Spain,Bulgaria,Italy,United Kingdom
Call:  (FP7-SME-2008-2, 2008)
Start date: 2011-03-01
End date: 2014-02-28
Duration (months): 36.0
Total project cost (EUR): 2864556.5
EU funding (EUR): 1956059.6
Participants: 12
Project status: CLOSED

5,720 people die yearly in the European Union as a consequence of work-related accidents, according to EUROSTAT figures (2005). Beside human losses, these incidents cost SMEs time and the availability of specific human expertise which directly translates into money and competitiveness. Moreover, to reduce time to market, shorter decision times and high speed productivity are demanded, and this might potentially lead to more risks for safety and health. On the other hand, and although occupational safety and health (OSH) regulations are obligatory and enforced by legal authorities, SMEs have limited resources in time, money and personnel, so it tends to be not regarded as a priority. Therefore, it seems necessary to stimulate awareness and to provide European SMEs with modern and user-friendly tools to support their understanding and compliance of OSH regulations. The IMOSHION project will establish novel methods to enhance SMEs productivity at both organisational and technological levels through better integration of OSH into their daily workflow. The project is targeting all manufacturing sectors (e.g. construction, machine building, metal working, aerospace, food industry) for which OSH concerns are the most challenging. Initial work will be carried out to elicit the technological requirements of SMEs by providing the RTD performers with a further definition of the tools to be developed. The RTD performers in collaboration with the SME associations will develop the set of OSH-related tools of the IMOSHION project. This will include (a) an OSH knowledge and learning management system, (b) a workplace simulation for experimenting and training on OSH issues, (c) an immersive training and learning tool for OSH procedures, and (d) a planning tool for OSH prevention at workstation and workplace levels. The SME associations will support validation, training as well as dissemination activities to transfer the project results to their SME members and beyond.

Keywords: simulation technology,virtual reality & virtual environments,mixed reality
INNOVATIVE FIRE PROTECTIVE COATINGS FOR STEEL STRUCTURES (STEELPROST)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SME associations
Action type: Research for the benefit of specific groups
Countries involved: Spain,Slovenia,France,United Kingdom,Spain,Spain,Belgium,Italy,Germany
Call:  (FP7-SME-2008-2, 2008)
Start date: 2010-05-01
End date: 2012-10-31
Duration (months): 30.0
Total project cost (EUR): 2368529.32
EU funding (EUR): 1871649.0
Participants: 11
Project status: CLOSED

Current methods to provide fire protection of light steel structures include the nowadays most efficient approach of intumescent paints, which are typically applied on-site on a mounted structure using brushes or spray guns. Such treatments are generally achieved through the preparation of the surface by grit/shot blasting, followed by the application of a primer, and followed by the application of several layers of intumescent coatings. This methodology has a number of drawbacks for a large community of end users, including: a)Drying times of intumescent coatings are very long, resulting in high cost associated to labour, site disruption, and space required for painting; b) As a consequence of those significant costs and burdens, the reality is that many end users, particularly SMEs, end up applying fewer layers than required, uneven or irregular layers, or none at all, breaching therefore current legislation, facing serious penalties and fees and endangering the security of their own installations. The STEELPROST project aims to provide a solution to current surface treatment limitations, by developing a second generation of fire-protective coatings that are: easier to paint on, covering a larger area faster, having improved adhesion and quick drying properties. This will be achieved through 3 core innovations: 1)Development of low cost fire-retardant agents using novel tin-based technology, based on nontoxic halogen-free additives ; 2)Combination of the above fire retardant agents with further nanoparticle additives to confer the paint outstanding adhesion to the metal, and increase abrasion and wear resistance properties; 3)Design and optimisation of a procedure for fast curing of the coating using existing heating source technologies such as infra-red (IR). The proposed technology is expected to reduce steelwork treatment cost in constructional projects on a 25% for on-site applications and 50% for off-site application.

Keywords: flame retardant,zinc stannate,nano-clay,synergy,smoke suppression.
Establishing the scientific bases and technical procedures and standards to recover the European flat oyster production through strategies to tackle the main constraint, bonamiosis. (OYSTERECOVER)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SME associations
Action type: Research for the benefit of specific groups
Countries involved: Spain,Spain,Ireland,United Kingdom,Netherlands,France,Denmark,Ireland,Netherlands,United Kingdom,France
Call:  (FP7-SME-2008-2, 2008)
Start date: 2010-05-01
End date: 2013-10-31
Duration (months): 42.0
Total project cost (EUR): 3199005.58
EU funding (EUR): 2475513.89
Participants: 16
Project status: CLOSED

The European flat oyster, has been part of the human diet for many centuries. High mortality episodes and overfishing decimated the populations of O.edulis in Europe through the first half of the XXth century. Then, two diseases (due to Marteilia refringens and Bonamia ostreae) spread in the early 1970s and 1980s, drastically reducing the production. Despite new management practices, and intensive repletion programmes, the production of O. edulis has remained low since that time. The recovery of European flat oyster production is seen as an important opportunity for the shellfish industry in Europe. Thus this project proposal aims to attain a clear competitive advantage for a number of SME AGs and their members for different reasons: 1st- Chance to diversify production (risk management) 2nd- High market value of the product. 3rd- Environmental positive effects of fostering aquaculture activities based on native species 4rd-Biotechnology provides tools and procedures to face the oyster industry problems that were not available until recently A total of five Shellfish Producer Associations from four different Member States and three SMEs in major oyster production countries in Europe, concerned about the above mentioned issues and being aware of recent scientific progress in selective breeding programmes for bonamiosis tolerance, decided to work together with the common general objective of facing the challenge of establishing the scientific and technical bases, procedures and standards that allow the recovery of the O. edulis production, through development of strategies to tackle the main constraint, bonamiosis . To successfully achieve this goal those European Research Centres and Universities which have mainly contributed to scientific progress on O. edulis recovery and selective breeding programmes for bonamiosis resistance, will be hired by the SM-AGs and SMEs involved in this OYSTERECOVER proposal to carry out the relevant research.

Keywords: bonamiosis,tolerant strains,selective breeding
Rapid Biosensor for the Detection of Mycotoxin in Wheat (MYCOHUNT)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SME associations
Action type: Research for the benefit of specific groups
Countries involved: Hungary,Spain,Italy,Belgium,Sweden,France,Greece,Belgium,Hungary,Poland,Hungary,Greece,Greece,United Kingdom,Netherlands
Call:  (FP7-SME-2008-2, 2008)
Start date: 2010-09-01
End date: 2013-08-31
Duration (months): 36.0
Total project cost (EUR): 3589101.02
EU funding (EUR): 2670740.0
Participants: 19
Project status: CLOSED

Mycotoxins are naturally occurring secondary metabolites produced by certain moulds/fungi as a result of their organic processes. Unfortunately, most mycotoxins are known to hazardously contaminate crops and consequently animal feeds and animal products, causing significant economic losses associated with their impact on animal and human health, animal productivity and domestic and international trade. While the economic effects are not easily calculated due to the several participants in the grain sector, European Union is setting stricter and stricter limits of mycotoxin concentrations. Deoxynivalenol also known as DON or vomitoxin is one of about 150 related compounds known as the trichothecenes that are formed by a number of species of Fusarium and some other fungi. It is nearly always formed before harvest when crops are invaded by certain species of Fusarium such as F. graminearum and F. culmorum. Our goal would be twofold: -developing a new sampling technique guaranteeing a 95% bulk transparency, -adapting a biosensor technology for the detection of deoxynivalenol. The electrochemical detection was selected as the amperometric sensor technology using a special biorecognitive layer proved to be the most reliable, low-cost method to be used in an on-site operating device. Our proposed solution will provide an easy-to-use, environmentally friendly, continuously operating system to fight against the mycotoxin infection.

Keywords: biosensor,amperometry,immunoassay,deoxynivalenol,don,sampling,filtering
Facilitate IT-providing SMEs by Operation-related Models and Methods (FACIT-SME)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SME associations
Action type: Research for the benefit of specific groups
Countries involved: Germany,Spain,Hungary,Italy,Spain,Spain,Belgium
Call:  (FP7-SME-2008-2, 2008)
Start date: 2010-01-01
End date: 2012-06-30
Duration (months): 30.0
Total project cost (EUR): 2549445.0
EU funding (EUR): 1980000.0
Participants: 18
Project status: CLOSED

The FACIT SME project addresses SMEs operating in the ICT domain. The goals are (a) to facilitate the use of Software Engineering (SE) methods and to systematize their application integrated with the business processes, (b) to provide efficient and affordable certification of these processes according to internationally accepted standards, and (c) to securely share best practices, tools and experiences with development partners and customers. The project targets (1) to develop a novel Open Reference Model (ORM) for ICT SME, serving as knowledge backbone in terms of procedures, documents, tools and deployment methods; (2) to develop a customisable Open Source Enactment System (OSES) that provides IT support for the project-specific application of the ORM; and (3) to evaluate these developments with 5 ICT SMEs by establishing the ORM, the OSES and preparing the certifications. The approach combines and amends achievements from Model Generated Workplaces, Certification of SE for SMEs, and model-based document management. The consortium is shaped by 4 significant SME associations as well as a European association exclusively focused on the SME community in the ICT sector. Five R&amp;D partners provide the required competences. Five SMEs operating in the ICT domain will evaluate the results in daily-life application. The major impact is expected for ICT SMEs by (a) optimising their processes based on best practise; (b) achieving internationally accepted certification; and (c) provision of structured reference knowledge. They will improve implementation projects and make their solutions more appealing to SMEs. ICT SME communities (organized by associations) will experience significant benefit through exchange of recent knowledge and best practises. By providing clear assets (ORM and OSES), the associations shape the service offering to their members and strengthen their community. The use of Open Source will further facilitate the spread of the results across Europe.

Keywords: model generated workplaces,engineering best practices,model based knowledge sharing,certification
Development and application of environmental Life Cycle Impact assessment Methods for imProved sustAinability Characterisation of Technologies (LC-IMPACT)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Environmental technologies
Action type: Collaborative project
Countries involved: Netherlands,Switzerland,Denmark,Netherlands,Austria,United Kingdom,Germany,Netherlands,European organisations area,Spain,Germany,Sweden,Sweden,Denmark
Call:  (FP7-ENV-2009-1, 2009)
Start date: 2009-12-01
End date: 2013-05-31
Duration (months): 42.0
Total project cost (EUR): 4491805.87
EU funding (EUR): 3413950.0
Participants: 16
Project status: CLOSED

LC-IMPACT is a 3.5-year project and its main objective is the development and application of life cycle impact assessment methods, characterisation and normalisation factors. Impact from land use, water use, marine, mineral and fossil resource use, ecotoxicity and human toxicity, and a number of non-toxic emission-related impact categories will be considered in LC-IMPACT. First, new impact assessment methods will be developed for categories that are not (commonly) included in life cycle impact assessments and categories for which model uncertainties are very high, i.e. land use, water exploitation, resource use, and noise. Second, LC-IMPACT will provide spatially explicit characterisation factors based on global scale models for land use, water exploitation, toxicants, priority air pollutants, and nutrients. Thirdly, parameter uncertainty and value choices will be assessed for impact categories with high uncertainties involved, such as ecotoxicity and human toxicity. Fourthly, ready-to-use characterisation factors will be calculated and reported. Fifthly, normalisation factors for Europe and the world will be calculated for the impact categories included. Sixthly, the improved decision support of the new characterisation factors and normalisation factors will be demonstrated in the context of the following three case studies: i) food production (fish, tomatoes, margarine), ii) paper production and printing, and iii) automobile manufacturing and operation. Finally, verification and dissemination of the new life cycle impact assessment methods and factors will be done by a portfolio of actions, such as stakeholder consultation, a project website, workshops, course developments, and training of user groups. In short, LC-IMPACT will provide improved, globally applicable life cycle impact assessment methods, characterisation and normalisation factors, that can be readily used in the daily practice of life cycle assessment studies.

Keywords: life cycle impact assessment methods,characterisation factors,normalisation factors,uncertainty analysis,lca case studies
CERTIFIED COMPLEXITY (CERCO)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Future and emerging technologies
Action type: Collaborative project
Countries involved: Italy,France,United Kingdom
Call:  (FP7-ICT-2009-C, 2009)
Start date: 2010-02-01
End date: 2013-03-31
Duration (months): 38.0
Total project cost (EUR): 1528094.0
EU funding (EUR): 1164533.0
Participants: 3
Project status: CLOSED

The project aims to the construction of a formally verified complexity preserving compiler from a large subset of C to some typical microcontroller assembly, of the kind traditionally used in embedded systems. The work comprise the definition of cost models for the input and target languages, and the machine-checked proof of preservation of complexity (concrete, not asymptotic) along compilation. The compiler will also return tight and certified cost annotations for the source program, providing a reliable infrastructure to draw temporal assertions on the executable code while reasoning on the source. The compiler will be open source, and all proofs will be public domain.

Keywords: verification,proof checking,program extraction,compilers,assembly,complexity