Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Fostering a European Research Area for Health Research (ERA4Health)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: COFUND actions
Partnership: ERA for Health (co-funded)
Countries involved: Spain,Netherlands,France,Italy,Norway,Germany,Portugal,Egypt,Belgium,Poland,Lithuania,Latvia,Austria,Israel,Romania,Greece,Slovakia,Ireland,Hungary,Türkiye,Denmark,Taiwan, Province of China,Estonia,Czechia
Call: European partnership fostering a European Research Area (ERA) for health research (HORIZON-HLTH-2022-DISEASE-03, 2022)
Start date: 2022-11-01
End date: 2029-10-31
Duration (months): 84.0
Total project cost (EUR): 110150222.5
EU funding (EUR): 33045066.75
Participants: 50
Project status: SIGNED

Excellent EU programs push health R&I but are not sufficient. Synergy with strategic initiatives in MS and a new model for impactful collaborations are needed to address the challenges for health. ERA4Health brings the opportunity to increase EU transnational collaborative research funding by creating a funding body for joint programming in priority areas addressing EU Public Health Needs, with total duration of 7 years. ERA4Health focuses on tackling diseases and reducing disease burden and the following challenges: 1) the increasing demand for a better quality of life and a better care of patients, 2) the need to transform public health care systems in more effective, efficient, equitable, accessible, and resilient ones and 3) the need to strengthen disease prevention and health promotion. In this view, ERA4Health objectives are: .SO1- Support relevant medical research including clinical fields and intervention areas (prevention, diagnosis, treatment) .SO2- Improve the utilisation of existing health technologies in clinical practice .SO3- Build capacity, in particular in conducting Investigator Initiated Clinical Studies at EU scale .SO4- Implement and advance the practice of RRI across the breadth of the programme ERA4Heatlth will be implemented in 2 phases: . Phase 1 (2 years) will implement joint calls focused on nutrition and lifestyle-related diseases, cardiovascular diseases and nanomedicine (4 in two years). In parallel, it will establish a supporting framework to overcome the challenges in launching international IICSs joint calls. . Phase 2, if the EC approves it: additional multinational calls for IICSs and joint calls for other priority areas will be launched in accordance with the decision of the Health Programme Committee taken at the end of previous Phase 34 partners (20 from EU, 3 Third Countries associated to HE and 2 non-associated, non EU), will commit 90,510,000€, during the 3 first years, as financial support to third parties.

Keywords: cofund,clinical trials,era,investigator initiated clinical study,cardiovascular,nanomedicine,nutrition,diet related diseases,healthy life style,rri,public health,prevention,joint calls
Mobilising novel finance models for health promotion and disease prevention (Invest4Health)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: Research and Innovation actions
Countries involved: Sweden,Netherlands,Norway,Hungary,Belgium,Germany,Spain,United Kingdom
Call: Better financing models for health systems (HORIZON-HLTH-2022-CARE-08, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 4468658.69
EU funding (EUR): 4468658.69
Participants: 18
Project status: SIGNED

In the medium to longer-term, the fiscal space that governments have to provide additional budgetary resources will shrink, including for healthcare. Our response is that it is better to pre-empt rather than repair i.e., to incentivise new ways of financing health promotion and disease prevention. The financing solution is smart capacitating investment. This means sharing risks and resources to invest at scale across multiple levels within health ecosystems generating sustainable returns and localised benefits. The specific objectives are: 1. Draw on available evidence to strengthen how smart capacitating investment is framed and communicated 2. Assess and enhance organisational readiness for testing SCI models in the regional test-beds 3. Develop and test business models that are compatible with smart capacitating investment 4. Develop and test novel finance models to determine which of the business models align with pre-defined contingencies for delivering smart capacitating investment 5. Develop and test a prototype collaborative platform for governing smart capacitating investment in health promotion and prevention. With an interdisciplinary approach we calibrate and harmonise 3 main work streams: developing functional prototype models of the anchoring concept (smart capacitating investment) [WP2-4]; iterative testing in real world environments (ES,DE,SE,UK initially with an Open Call for a 2nd tranche of transition and less developed regions) to show relevance in tax and insurance-based systems [WP5-6]; preparing a social franchising package for large-scale demonstration [WP7]. Underpinning these workstreams, we will also explore and test platform-based collaborative spaces for the involvement of resourced citizen panels and local communities in planning and investment decisions for interventions and services. The project generates concrete outcomes and impacts for further development and uptake of smart capacitating investment that disrupts state-of-the-art.

Keywords: ecosystem services,preventive health,health promotion,financing models for sustainable health,testbed interventions and evaluation
Energy-Efficient Highly Accurate Data Prefetching (Berti-Chip)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-05-01
End date: 2025-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Data prefetchers are ubiquitous in current high-performance computers such as those manufactured by Intel, ARM, AMD, or IBM, as they play a fundamental role in hiding long-latency memory accesses. Prefetchers predict the data that will be needed by a processor in the future and fetch such data ahead of execution. State-of-the-art data prefetchers, push the limits of performance but often without caring about energy efficiency. The energy efficiency of a prefetcher is dictated by its accuracy, which measures the percentage of data moved by the prefetcher that satisfies the processor demands. Berti is a data prefetcher sited at the first-level data cache (L1D) that makes a compelling case for timeliness and accuracy. Berti can boost processors performance by 33% (with respect to those not using prefetching mechanisms) and 8.5% (when compared to mainstream prefetchers) while providing an accuracy above 90%, which translates into a low energy overhead of the memory hierarchy. In addition, Berti is a cost-effective prefetcher that just requires 2.55KB of storage. The objective of this project is to elaborate a hardware design for the Berti data prefetcher, as we strongly believe that the notable boost in processor performance and efficiency along with its design simplicity makes Berti a serious candidate both for the emerging low-power edge market and for high-performance computers.
Focused Ultrasound Personalized Therapy for the Treatment of Depression (UPSIDE) (UPSIDE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Netherlands,Belgium,Germany,United States,Italy,Portugal
Call: Tools to measure and stimulate activity in Brain Tissue (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-09-01
End date: 2026-11-30
Duration (months): 51.0
Total project cost (EUR): 4149921.25
EU funding (EUR): 4149921.0
Participants: 7
Project status: SIGNED

Major depressive disorder (MDD) is the leading cause of disability worldwide, affecting 300 million people with a lifetime prevalence of 15%. Approximately one third of all MDD patients fail to respond to currently established treatments based on medication and psychotherapy, thus falling into the category of Treatment-Resistant Depression (TRD) patients. Electroconvulsive therapy (ECT), repetitive Transcranial Magnetic Stimulation (tRMS), Vagus nerve stimulation, deep brain stimulation (DBS) and transcranial focused ultrasound (tFUS) still show poor spatial resolution (ECT, tRMS, tFUS) or low network coverage (VNS, DBS), with average remission rates in clinical trials still lower than 30 %. Apart from the existing stimulation hurdles, reliable biomarkers for depression are needed as a diagnostic tool, and, in the case of NT, to determine the stimulation efficacy and allow for personalized treatment. The UPSIDE project proposes a minimally invasive, high spatial resolution and multi-brain region stimulation and recording system to largely exceed the capabilities of existing NT for depression. Our objective is to research and validate in vivo an hybrid neurotechnology consisting of an epidural focused ultrasound (eFUS) stimulator employing three-dimensional beamforming, and a high-density epidural EEG recording system. Epidural deployment of these devices will be enabled by novel methods for massive integration and miniaturization of high-performing piezoelectric ultrasound materials and high-fidelity organic bioelectronic materials with high energy-efficient complementary metal-oxide semiconductor (CMOS) technology in a biocompatible manner. The UPSIDE project will result in a demonstrator which will allow, for the first time, network stimulation and simultaneous biomarker readout in behavioral experiments with animal models featuring depression-like symptoms. This technological breakthrough will pave the way towards a personalized treatment for TRD.

Keywords: ultrasound neuromodulation,neuronal recording,closed loop stimulation,treatment resistant depression
Literary Translations at War: Mapping World War 2 in Europe (1939-45) (TranslAtWar)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2128708.0
EU funding (EUR): 2128708.0
Participants: 1
Project status: SIGNED

While the history of translation is a field in Humanities that has known a significant increase recently worldwide, a European history of literary translation during the war has yet to be written. Due to the importance of power relations, ideology, censorship and propaganda, the practice of literary translation and European translators in wartime is a particularly interesting configuration, but it remained relatively unexplored so far on a truly European level: few comprehensive researches have been carried out on literary translation in Europe during this constrained historical context, unlike on translation practices during peacetime. What was translated (how and by whom) whilst wars were destroying bonds between people and States? What meaning does one then invest translation with? Focussing on World War 2, a very significant period of 20th century European history, the TranslAtWar (Literary Translations at War) research project aims at investigating how literary translation then contributed to the understanding of History in the making, and, reciprocally, how History contributed to the analysis of multiple forms of literary translation. It is about questioning the circulation of ideas and culture through translation, and equally taking a close interest in the role of the agents of these circulations, both male and female translators, during wartime. We will also question the impact that the practice of translation in such exceptional historical circumstances had on the intellectual and cultural development of several countries, and what it is likely to have contributed given their position (central or peripheral) in the world of European literature. Under my supervision and taking advantage of long-standing international partnerships and expertise, this innovative project aims at writing a new page of European history and, eventually, promoting the emergence of a new disciplinary field at the crossroads of translation studies and war studies.

Keywords: literary translation,translators,translation history,literature,world war 2 ww2,europe,propaganda,censorship,ideology,cultural transfers
Stackable surface rationalization for freeform architectural design (STACK)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Norway,Denmark,United Kingdom
Call: EIC Pathfinder Challenge: AEC digitalisation for a new triad of design, fabrication, and materials (HORIZON-EIC-2023-PATHFINDERCHALLENGES-01, 2023)
Start date: 2024-10-01
End date: 2028-03-31
Duration (months): 42.0
Total project cost (EUR): 3055280.0
EU funding (EUR): 3055280.0
Participants: 3
Project status: SIGNED

STACK will pioneer a mathematical framework and develop computational design tools for freeform surface stackability complemented by 3D elastica theory, unlocking the potential for advanced digital fabrication workflows, such as hot blade cutting, demonstrating our technology's capabilities within the Architecture, Engineering, and Construction (AEC) sector.

Keywords: computational design,freeform architecture,digital fabrication,stackability,elastica,hot blade cutting
Between the sacred and the mundane: A historical inquiry into travel and travelling practices on the Ottoman pilgrimage road from Üsküdar, c. 1517-1800. (OTTOHAJJ)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Türkiye
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2023-10-11
End date: 2025-10-10
Duration (months): 24.0
Total project cost (EUR): 148478.4
EU funding (EUR): 148478.4
Participants: 1
Project status: SIGNED

The hajj caravan was likely the largest and most regular flow of peoples and commodities through the arteries of the Ottoman empire. Yet surprisingly little is known about the experiences of Ottoman pilgrims who took the overland route to Mecca and Medina each year. OTTOHAJJ will investigate early modern (c. 1517-1800) Ottoman travel through an in-depth study of the material and human aspects of the caravan from Üsküdar to Mecca. The project has four main objectives: Undertaking research in manuscript libraries in order to build a corpus of Ottoman hajj guidebooks authored by pilgrims; Classification and analysis of these sources, exploring intertextuality, authorship, and milieu of authors; Investigating the infrastructure of pilgrimage in order to produce a typology of locations, including sacred sites, facilities, and places of leisure, rest and relaxation; Constructing a typology of social profiles and associated traveling patterns of pilgrims. The use of guidebooks will be supplemented by other Ottoman Turkish and Arabic sources, including travelogues, chronicles, documents, objects, and images. The project will provide data on the diverse territories of the former Ottoman empire and traveling practices within them, a crucial undertaking since climate change and rapid urban transformations continue to irreversibly alter the landscape and diminish ecological diversity. This data will allow us to better understand the social, religious, cultural, ecological, and scientific history of the early modern empire. The project will also make important contributions to the study of manuscript cultures and the application of digital humanities in Ottoman studies. Project outputs include a monograph on traveling practices and mobility, a critical edition of a late-sixteenth-century manuscript guidebook, digital maps of locations and network maps of guidebook authors, a project website promoting open science and open access, and participation in conferences and symposiums.

Keywords: travel,travelling practices,ottoman,ottoman history,pilgrimage,hajj,applied science,material culture,guidebooks,environmental history
Deep learning of chemical reactions (DeepRxn)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 1499285.0
EU funding (EUR): 1499285.0
Participants: 1
Project status: SIGNED

The exploration of reactions is a central topic in chemistry. Compared to the success of machine learning for molecules, the modeling of reactions is lagging behind, especially for stereo- and regioselective reactions. Since current efforts toward sustainable synthesis such as asymmetric organocatalysis or biocatalysis rely on the accurate prediction of enantio- and regioselective reaction pathways, new modeling approaches are needed. The proposed project aims toward developing new, data-driven deep learning frameworks for modeling organic and enzymatic reactions, focusing on chemo-, regio-, and stereoselectivity arising through intermolecular interactions with the reagent, solvent, or catalyst. In detail, we target the rule-free, stereochemistry-aware modeling and subsequent experimental validation of asymmetric organocatalysis to identify new enantioselective transformations, the exploration of new biocatalytic synthesis pathways including enzymatic cascades, and the accurate prediction of activation energies via developing new deep learning approaches. We will expand molecular graph-convolutional neural networks and graph transformers to reactions in a rule-free manner, and introduce hidden three-dimensional representations to account for stereochemistry and intermolecular interactions, yielding a versatile, open-source toolbox for reaction deep learning. This approach largely surpasses current approaches, which rely on two-dimensional representations, reaction rules, or three-dimensional input data, in offering the opportunity to model three-dimensional aspects and atom-mapping on-the-fly, for the first time, representing a significant breakthrough in this field. Its experimental validation campaign further allows for a direct application to the identification of new asymmetric organocatalytic transformations, as well as enzymatic cascades including cofactor recycling and side-product reduction, addressing the current need for more sustainable synthesis.

Keywords: machine learning deep learning reaction properties enzymatic cascade design asymmetric organocatalysis
Burden of disease based methods for estimating the socio-economic cost of environmental stressors (BEST-COST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: Research and Innovation actions
Countries involved: Belgium,Germany,Denmark,Estonia,Finland,France,Netherlands,Norway,Portugal,United States,Switzerland
Call: Methods for assessing health-related costs of environmental stressors (HORIZON-HLTH-2022-ENVHLTH-04, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 4185218.75
EU funding (EUR): 3997718.25
Participants: 17
Project status: SIGNED

The outdoor environment has a significant impact on our health and wellbeing. The European Green Deal has introduced the ambitious commitment to a ‘Zero-Pollution Action Plan for air, water, and soil’ to protect humans and the environment. Evidence-based policy making on environmental stressors is however hampered by the methodological challenges to quantify their socio-economic costs. The overall objective of BEST-COST is to improve methodologies for the socio-economic cost assessment of environmental stressors to i) enhance regular usage of economic and health modelling in policy impact assessments and policy evaluation; and ii) promote harmonised and consensus metrics for integrative socio-economic assessments of environmental stressors in Europe. BEST-COST will develop an improved and consensual burden of disease (BOD) framework for estimating the health impact of environmental stressors, with a focus on air pollution and noise and their interactions; an improved and consensual methodology for monetization of BOD estimates of environmental stressors; and a coherent methodological framework for assessing social inequalities in the socio-economic cost of environmental stressors. The methods will be co-developed with key stakeholders, made available as open access tools, and trialled in different EU countries. To ensure sustainability, transferability of the knowledge and methods developed by BEST-COST to other countries and stressors will be established. BEST-COST is conducted by a strong and unique consortium, gathering world-class expertise on environmental BOD assessment. The BEST-COST consortium consists of 17 organisations from 10 EU countries and the USA, and will be supported by an Advisory Board including representatives from JRC, EEA, and WHO. The consortium bridges the expertise from the Global Burden of Disease study, via the inclusion of IHME and key GBD collaborators, with that of national BOD studies, and will translate this expertise to EU agencies

Keywords: environmental burden of disease,health inequalities,monetization,air pollution,noise