Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Communications at the Synapse - a Near Atomic Resolution View into Cell-Cell Communication in the CNS (CellCellEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 1499885.0
EU funding (EUR): 1499885.0
Participants: 1
Project status: SIGNED

Synapses are intercellular junctions specialized for coordinated cell-cell communication throughout the nervous system. They are organized by cell-adhesion molecules (CAMs) that bi-directionally orchestrate neuronal communication. Latrophilins (LPHNs) are a unique sub-family of CAMs that play critical roles in structuring the synaptic architecture through multifaceted interactions with a large variety of synaptic partners. Mutations in LPHN have been associated with neurodevelopmental and neuropsychiatric disorders. Despite their gravity, the mechanism governing LPHN synaptic activities remain elusive. To further our understanding of LPHN-mediated cell-cell communication, we suggest to characterize these receptors’ interactions with their intracellular and extracellular partners. For this purpose, we propose to adopt a hybrid approach driven primarily by cryo-EM, a state-of-the-art technique capable of dissecting the molecular mechanisms of super-molecular assemblies at extremely high spatial resolutions, which is our group’s main field of expertise. The cryo-EM studies will be complemented by cryo electron tomography (cryo-ET), fluorescence microscopy and biochemical approaches. Our specific aims are: Aim 1: Dissect the molecular mechanisms of LPHN activation by combining cryo-EM with biochemical methodologies. Aim 2: Characterize the LPHN interactome through cryo-EM and fluorescence microscopy. Aim 3: Resolve the architecture of the LPHN interactome at a close-to-native environment through cryo-ET. Our experimental strategy will generate a quantitative, near-atomic resolution view of LPHNs and the mechanism by which they interact with their synaptic partners and instigate trans-synaptic signal transduction. These data will be vital for understanding LPHN-mediated cell-cell communication as well as the mechanisms governing trans-synaptic interactions and could potentially highlight novel approaches to treat neurodevelopmental and neuropsychiatric disorders.

Keywords: cryo em,cryo et,gpcr,cell cell adhesion
Sperone Speroni (1500-1588) and the Rebirth of Sophistry in the Italian Renaissance (SPERONI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

This two-year research project aims to analyze the works of Sperone Speroni degli Alvarotti (Padua 1500–1588), his re-evaluation of ancient sophistic perspectives and his legacy in the early modern age. Speroni was one of the most important protagonists of the Renaissance debate on language and logic as well as civil and speculative philosophy. Educated as an Aristotelian, he eventually developed a distinctive philosophy and was the first to challenge Plato’s (327-447 BCE) condemnation of sophists. Despite the fact that Speroni was a central figure of Renaissance philosophy and literature in the vernacular, he is one of the most neglected authors in scholarly production. Furthermore, scholars have considered Speroni’s interest in ancient sophists as a marginal aspect of his philosophy and have disregarded the paramount role of the period’s vernacular writing on sophistry that began with his works and spread throughout sixteenth-century Italy. This project will not only contribute to the research on vernacular Aristotelianism funded by an ERC Starting Grant 2013 (ARISTOTLE – 335949) and led by Marco Sgarbi but also fill the gap in international studies with a complete analysis of the subject. Teodoro Katinis, an Experienced Researcher educated in European institutions and at Johns Hopkins University (U.S.A.), presents a research proposal from which the ground-breaking findings will revolutionize the traditional scholarly approach to a crucial period of the history of Western culture. Katinis expects that the development of this project will profoundly impact his career. Thanks to the training provided by Ca’ Foscari University in Venice and to its international network, Katinis will acquire new skills and build fruitful relations with European institutions and scholars. The training, network and publication of the project’s outcomes will increase Katinis’ possibilities of obtaining an eventual ERC Grant.

Keywords: sperone speroni,renaissance,sophistry,italian aristotelianism,philosophy,literature
A global initiative to understand gypsum ecosystem ecology (GYPWORLD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Spain,Italy,Iran, Islamic Republic of,Argentina,South Africa,Australia,Cyprus,Türkiye,United States,Portugal,Chile,Mexico
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-01-01
End date: 2023-10-31
Duration (months): 70.0
Total project cost (EUR): 747000.0
EU funding (EUR): 724500.0
Participants: 19
Project status: SIGNED

Gypsum soils occur worldwide and represent natural laboratories of evolution and ecology. The unusual mineral content of gypsum soils is a significant barrier to the growth of most plants, and yet these soils host highly diverse endemic floras that have evolved independently on five continents. Nevertheless, these ecosystems are poorly understood compared to those of other unusual substrates. Little is known about the conservation status of gypsum floras, the potential impact of climate change on them, and their responses to mitigation and restoration. We propose an integrated global study of the ecology and evolution of plant and lichen life on gypsum, including eight gypsum-rich regions from four continents that differ in geological origin, climate, and flora. We will 1) assess the plant and lichen diversity of gypsum; 2) investigate the evolutionary origins and assembly of these floras; 3) evaluate potential adaptive mechanisms on gypsum, the functional structure of gypsum plant and lichen communities, and the processes regulating gypsum ecosystem function; 4) analyse the responses of gypsum communities to global change drivers and explore how gypsum ecosystem restoration/conservation may help mitigate the effects of global change; 5) promote the study of gypsum ecosystems; and 6) communicate the ecological and conservation value of these ecosystems to the public. With the involvement of gypsum experts from 18 academic and non-academic organizations from 11 countries, this project provides an innovative, integrative, and interdisciplinary approach to address key questions in gypsum ecosystem ecology, evolution, and management. The project thus strengthens existing international collaborative networks and consolidates Europe’s leadership in gypsum ecosystem research, including management and conservation plans and the identification of traits for crop improvement on gypsum soils, enhancing its attractiveness as a leading destination for related R&D

Keywords: gypsum ecosystems,evolution,conservation,ecological restoration,ecophysiology,functional ecology,community ecology,plant plant interactions,plants,lichens,endemic flora
Compact, light, efficient and reliable turbo compressor for fuel cell vehicles (Turbo-FuelCell)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Switzerland
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The stronger regulation of carbon dioxide emissions, rising consumer awareness towards eco-friendly energy sources, and the need to minimize our dependency on fossil fuels are boosting the fuel cell electric vehicle (FCEV) market. Fuel cells need to be fed with a constant supply of oxygen, usually from air provided by a compressor. While much attention has been put on the fuel cell itself and the hydrogen storage, the oxygen supply has not been yet optimized. Currently, air management for fuel cell systems remains a challenge because today’s compressor technologies are not optimized for fuel cell applications. We are CELEROTON, a Swiss high-tech business at the forefront of high-speed turbo compressor technology. We are able to achieve speeds up to 300,000 rpm, which allows our product to be 20 times lighter and smaller than state-of-the-art compressors, while achieving the highest efficiency of all commercial compressors. Moreover, our compressor is 100% oil-free which results in the highest air purity, crucial to increase the fuel cell lifetime. Since our foundation in 2008, we have invested over 1.6M€ to develop our compressor technology up to near-commercial stage. Now, with project TURBO-FUELCELL, we aim to take the last technical and commercial steps to introduce our unique turbo compressor as the key technology for oxygen supply in the fuel cell vehicle market. This market with such growth potential (predicted to increase at 22.1% CAGR up to 2024 reaching 1.2 B€), could greatly benefit from the compactness and lightness of our product. Our vision is contributing to the deployment of fuel cell vehicles in Europe, increasing their efficiency and decreasing their cost thanks to our compact, lightweight, quiet and reliable air compressor. We aim to achieve sales of 23,000 units in the first five commercialization years subsequent to this project, which will provide cumulated revenues of more than 60 M€ and cumulated gross profit of around 23 M€ by 2024.

Keywords: turbo compressor,compressor,fuel cell,fcev,compact,efficiency,high tech components,high speed,oxygen supply
Search engine for organising complete collaborative economy experiences. (WONOWO)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Spain
Call: New business models for inclusive, innovative and reflective societies (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The rise of the sharing economy is changing the face of European business – creating opportunities for new entrants, challenges for incumbent players, and searching questions for all stakeholders. A recent study for the European Commission (April 2016) names “Assessing the size and presence of the collaborative economy in Europe” shows that activity in the sharing economy across Europe has accelerated over the past two years and the collaborative economy start-up scene across Europe is form by at least 275 different platforms. By 2025, it is estimated that many areas of the sharing economy will rival the size of their traditional counterparts, with platforms generating Europe-wide revenues worth over €80bn and facilitating nearly €570bn of transactions . The problem with the sharing economy is that is has grown too fast becoming a highly fragmented sector. To realise this potential and attract the mass market, sharing economy platform providers will need to overcome trust issues and promote a culture of sharing. WONOWO offers a revolutionary business model offering a one-stop-shop and unique identity for collaborative economies in order to aggregate in one single platform all the third party services demanded by the consumers. The aim is to prevent fragmentation of the Single Market and boost collaborative economy high level competitiveness internationally potential, by providing a single and open platform and digital identity to drive growth while unlocking the value of underused assets by matching needs and haves. WONOWO facilitates the access, comparison and all-in-one management of collaborative services. This point is especially beneficial as it provide growth opportunities for innovative start-ups and existing European companies, both in their home country and across borders.

Keywords: collaborative economies,online platforms,mobile,search engines
European Virus Archive goes global (EVAg)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,South Africa,Germany,Germany,Italy,Australia,Switzerland,Slovenia,Slovakia,Sweden,China,Russian Federation,France,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Integrating and opening existing national and regional research infrastructures of European interest (H2020-INFRAIA-2014-2015, 2014)
Start date: 2015-04-01
End date: 2020-07-31
Duration (months): 64.0
Total project cost (EUR): 12168054.68
EU funding (EUR): 10792868.0
Participants: 29
Project status: SIGNED

The overall objective will be to create and mobilise an International network of high calibre centres around a strong European group of institutes selected for their appropriate expertises, to collect, amplify, characterise, standardise, authenticate, distribute and track, mammalian and other exotic viruses. The network of EVAg laboratories including 25 institutions represents an extensive range of virological disciplines. The architecture of the consortium is based on the association of capacities accessible to the partners but also to any end-users through the EVAg web-based catalogue. This concept has been elaborated and tested for its efficiency during the successful EVA project (FP7). The project will integrate more facilities dedicated to high risk pathogen (HRP) manipulation (1 in EVA, 13 in EVAg) The access to products derived from those HRP will be enhanced and for instance the production of diagnostic reagents will be facilitated. The new project will also provide access to high containment biosafety facilities to carry out in vivo studies of infectious disease using natural or models hosts, to look at prophylactic or therapeutic control measures and to develop materials for the evaluation of diagnostic tests, meaning an extensive capacity to service and to training. EVAg will also link up with other network-based virus-associated programmes that exist globally. However, looking further ahead, EVAg is conceived ultimately to be an open entity aiming at developing synergies and complementarity capabilities in such a way as to offer an improved access to researchers. This project will generate the largest collection of mammalian viruses in the world and move beyond the current state-of-the-art to provide an increasingly valuable resource and service to the world’s scientific community, including government health departments, higher education institutes, industry and, through information systems, the general public.

Keywords: virus collection,derived products,support to response,gold standard products
A novel platform for the direct profiling of circulating cell-free ribonucleic acids in biofluids (diaRNAgnosis)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Italy,Italy,Netherlands
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-01-01
End date: 2025-05-31
Duration (months): 53.0
Total project cost (EUR): 759000.0
EU funding (EUR): 759000.0
Participants: 7
Project status: SIGNED

Circulating cell-free ribonucleic acids (ccfRNAs) represent an emerging and important class of molecules, able to provide significant clinical relevance as novel screening, prognostic and therapy monitoring biomarkers in cancer. Through analysing specific ccfRNAs, different cancers can be accurately correlated for type and stage. Sadly, despite extensive academic and clinical research identifying and validating in limited clinical trials, ccfRNAs have not yet entered the field of clinical diagnostics. This is amongst others because the current analytical methods remain less than satisfactory, and until now ccfRNA detection remains therefore challenging, costly, and requires elaborate multi-step sample preparations. Prompted by these current analytical limitations, two innovative EU companies, DESTINA Genomica SL (Spain) and OPTOELETTRONICA ITALIA SRL (Italy) have developed the “ODG Platform” for direct quantitative measurement of circulating RNA molecules. The diaRNAgnosis project objective is to complete development of the ODG platform, delivering reliable and robust detection of novel ccfRNA signatures that could be linked to specific cancer types. To ensure timely delivery and success of the diaRNAgnosis project, DESTINA and OPTOI have considered and invited partners who they believe will add real value to the consortium. These are the Spanish company NanoGetic SL (specializing in nanotechnologies); three key academic research groups from the Universities of Trento and Catania (Italy), Granada (Spain); as well as the Princess Máxima Center (The Netherlands). This new pan-European, multidisciplinary and intersectoral team will develop a reliable and innovative method and platform to identify cancer biomarkers in liquid biopsies. The research collaboration will address the need to perform high sensitivity/high specificity analysis of ccfRNAs that are specifically and overexpressed in testicular germ cell tumour (TGCT) and prostate cancer (PCa) respectively.

Keywords: liquid biopsy,peptide nucleic acids,molecular diagnostics,cancer biomarkers,prostate cancer,testicular cancer,microspheres,sensors,circulating cell free rna,microrna
Symbolic Computation and Automated Reasoning for Program Analysis (SYMCAR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Austria
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2016-04-01
End date: 2021-06-30
Duration (months): 63.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Individuals, industries, and nations are depending on software and systems using software. Automated approaches are needed to eliminate tedious aspects of software development, helping software developers in dealing with the increasing software complexity. Automatic program analysis aims to discover program properties preventing programmers from introducing errors while making changes and can drastically cut the time needed for program development. This project addresses the challenge of automating program analysis, by developing rigorous mathematical techniques analyzing the logically complex parts of software. We will carry out novel research in computer theorem proving and symbolic computation, and integrate program analysis techniques with new approaches to program assertion synthesis and reasoning with both theories and quantifiers. The common theme of the project is a creative development of automated reasoning techniques based on our recently introduced symbol elimination method. Symbol elimination makes the project challenging, risky and interdisciplinary, bridging together computer science, mathematics, and logic. Symbol elimination will enhance program analysis, in particular by generating polynomial and quantified first-order program properties that cannot be derived by other methods. As many program properties can best be expressed using quantified formulas with arithmetic, our project will make a significant step in analyzing large systems. Since program analysis requires reasoning in the combination of first-order logic and theories, we will design efficient algorithms for automated reasoning with both theories and quantifiers. Our results will be supported by the development of world-leading tools supporting symbol elimination in program analysis. Our project brings breakthrough approaches to program analysis, which, together with other advances in the area, will reduce the cost of developing safe and reliable computer systems used in our daily life.

Keywords: automated reasoning,first order theorem proving,symbolic computation,formal methods,program analysis,program verification