Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Eradicating Chronic Infections (ERACHRON)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Italy
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2024-07-31
Duration (months): 78.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Given the alarming progression of chronic and relapsing infections in the last decades, and the even more alarming predictions for the upcoming years, it is urgent for chemists to be able to provide new molecular tools to study, and ultimately solve, these complex biological problems. Bacterial persisters are an elusive "dormant" phenotype that play a pivotal role in chronic infections, with mechanisms that remain to be fully unravelled. Current knowledge suggests that bacterial persisters are not genetically resistant to antibiotic treatment; they simply appear to shut down through a cascade of biochemical events called the stringent response (SR), becoming insensitive to current drugs. This subpopulation remains unaffected during the time of pharmacological treatment and represents a reservoir that sustains pathogen survival and resurgence. The goal of this project is to fill the knowledge gap between persisters formation and infection eradication, providing the community with potent and selective small molecular tools that can be used to challenge complementary survival mechanisms. I will adopt a combined approach targeting a specific cellular trigger of the persister phenotype with small molecules designed ad hoc in order to switch it off. The target is a bacterial protein involved in the SR cascade, whose activity is proposed to be allosterically regulated. Coordination propensity analysis of the dynamic behaviour of the target will highlight regulation sites exploitable to modulate and control the protein activity. Structure-based design, virtual fragment screening and chemical synthesis will operate in synergy. Experimental screening methodologies intrinsically rich in structural information, such as those based on NMR spectroscopy, will be privileged. The overarching goal is to identify molecules able to prevent the insurgence of the "dormant" drug-tolerant state and, possibly, revert the persisters already present to the "awake" drug-sensitive phenotype.

Keywords: bacterial persisters,computational chemistry
Microdata analysis for Policies for Productivity, Innovation, Growth and Inclusion (MapProdIGI)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Coordination and support actions
Countries involved: France
Call: Analysing the R&I productivity-inequality nexus (H2020-IBA-SC6-Nexus-2017, 2017)
Start date: 2018-07-01
End date: 2021-06-30
Duration (months): 36.0
Total project cost (EUR): 1657057.49
EU funding (EUR): 900000.0
Participants: 1
Project status: CLOSED

This project is part of efforts to go beyond the so-called “average firm paradigm” when studying cross-country differences in productivity and employment growth and understand the role of policies in Europe and beyond. The evidence base created by this project - based on a unique representative base of firm-level data from a large number of countries - can contribute to the coordination and increased focus of individual country policy efforts to design research and innovation policies and foster framework conditions that foster innovation, productivity growth and diffusion with the ultimate goal of achieving fairer and more inclusive societies. Thus, this project implements the goals of the Horizon 2020 Work Programme “Europe in a Changing World: inclusive, innovative and reflective societies. Building on OECD’s unique expertise and access to a sizeable network of official national experts; government officials and statistical offices this project aims to: 1. Provide new evidence on trends in business dynamism, productivity growth and productivity dispersion building internationally comparable representative evidence for a large set of countries. 2. Build a comprehensive evidence base for policy making on the role of innovation policies; structural policies and framework conditions for achieving inclusive growth in globalised digital economies. This would be achieved through within- and cross-country econometric micro-data analysis. 3. Foster knowledge sharing on firm-level data analysis in the areas of productivity and business dynamics in Europe and beyond.

Keywords: productivity innovation growth inclusion business dynamics
INdustrial Thermal Energy Reuse Enabled by Sorption heaTpumps (INTEREST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-10-01
End date: 2024-05-30
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

This work will further strengthen R&D skills of the applicant, especially considering the development of efficient sorption heat pump systems, extend his technical and nontechnical network, increase his knowledge regarding market demands and strategies and provide new career perspectives. The project aims at accelerating development and application of hybrid resorption heat pump for more energy efficient use of heat. A recast of European Performance of Buildings Directive indicated that higher energy efficiency is required for heating and cooling in building and industrial sector. Heat pumps can provide such efficient use, among which sorption heat pump could be a promising candidate. Due to various sorption working pairs, the heat with a wide temperature range could be recovered which almost saves 50% energy through desorption and sorption process compared to direct heating systems. So far, this technology has not been commercially realized in large-scale application or served as an auxiliary application. The project objectives are elaborated as follows: 1. Screen potential thermo-chemical sorbents with higher energy density through comprehensive review, develop and test the promising composite materials. 2. Develop a transient model for hybrid resorption heat pumps. 3. Design, construct and test a pair of resorption reactors that can operate over 1000+ cycles without noticeable loss of reactivity, and to be integrated with compressor for completing resorption system. 4. Conduct techno-economic analysis of hybrid heat pump for real industrial application. This proposal combines the applicant’s expertise concerning heat/mass transfer and reaction kinetics of sorbents with thermal engineering skills & experience of Dr. Carlos Infante Ferreira at TUDelft to achieve the high energy efficient sorption heat pump. These synergies will deliver a successful project as measured by well-defined deliverables, both in terms of hardware development and disseminated knowledge.

Keywords: adsorption,hybrid technology,heat pump,heat and mass transfer,adsorption kinetics
A DNA NANOtechology toolkit for artificial CELL design (NANOCELL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1497477.0
EU funding (EUR): 887487.65
Participants: 2
Project status: SIGNED

Bottom-up synthetic biology aims to artificially replicate the emerging behaviours of cellular life but struggles to do so without relying on poorly controllable machinery borrowed from biological cells. DNA nanotechnology enables ab-initio design of nanoscale objects with fully programmable structure and dynamic response, making them ideal to mimic the complex functionalities of biological machinery in a truly bottom-up fashion. NANOCELL will establish a fully modular and integrated platform that utilises DNA nanotechnology to prescribe structure and functionality of artificial cells. I will design a library of micron-scale DNA-based objects that mimic cell organelles in their ability to perform specific tasks in response to chemical and environmental stimuli including signal detection and amplification, the capture and release of cargoes, and the construction of structural elements. These “membrane-less organelles” will self-assemble from a new class of amphiphilic DNA building blocks I recently introduced, which enable unprecedented control over the morphology and response of nanostructured frameworks. Interaction between organelles will lead to the emergence of collective effects, and their encapsulation in lipid-bilayer compartments will enable the modular construction of artificial cells displaying a range of complex behaviours such as remote communication, dynamic adaptation, and spatiotemporal patterning in multicellular systems. NANOCELL will consist of three Work Packages reflecting its hierarchical approach: WP1: Mapping the self-assembly behaviour of amphiphilic DNA nanostructures. WP2: Embedding different functionalities in amphiphilic DNA frameworks to produce artificial organelles. WP3: Creating artificial cells by encapsulating DNA organelles in compartmentalised systems. The full programmability afforded by NANOCELL will ultimately unlock long-awaited applications of artificial cells, spanning from biosensing to smart therapeutics.

Keywords: structural dna nanotechnology,dynamic dna nanotechnology,artificial cells,bottom up synthetic biology,encapsulation,self assembly,amphiphilic molecules,phase behaviour
Dark galaxies: Probing the ΛCDM cosmological model on unprecedented scales (DarkGalaxies)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: SIGNED

The currently favoured Lambda-Cold-Dark-Matter (ΛCDM) cosmological model makes specific predictions about the abundance, structure and clustering of dark matter halos (DMHs), the sites where galaxies form. These predictions are accurate at describing large scale observations. On smaller scales, the agreement between ΛCDM and observations of dwarf galaxies is unclear because (i) the structure of DMHs depends on particularities of different galaxy formation models, and (ii) observations of dwarfs suffer from sizable uncertainties. Is ΛCDM successful on small scales? A definite answer to this major open question may either reveal the nature of DM or change dramatically our understanding of structure formation in the Universe. My research will deliver the foundations to probe ΛCDM on unprecedented small scales by exploiting a fundamental prediction of the model: the existence of nearby DM-dominated “dark” galaxies (so-called RELHICs). RELHICs are pristine collapsed DMHs that contain sufficient gas leftover from the epoch of reionization to recombine and emit radiation that can be observed in 21 cm (or recombination lines) but without becoming self-shielding and forming stars. Firstly, I will develop and analyse high-resolution hydrodynamical simulations performed with state-of-the-art numerical codes that include cutting-edge galaxy formation and radiative-transfer (RT) models to predict the abundance and clustering of RELHICs. Secondly, I will design robust survey strategies targeted at detecting RELHICs with current and upcoming observing facilities (e.g., ALMA, FAST, MEERKAT, WALLABY). The detection and characterization of REHICs will offer an unprecedented and clean probe to ΛCDM on scales that have not yet been probed. My extensive expertise in numerical simulations, cosmology and galaxy formation, combined with that of Prof. Michele Fumagalli in RT and physics of the interstellar medium will enable me to materialize my predictions into observational probes.
Bio-inspired capillary capture of viscous fluids with soft structures. (BioCapSoft)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: SIGNED

Capturing fluids at small scales is a challenge that nectarivores have solved by developing various type of specialized tongues, which consist of a complex assembly of flexible structures of small size compared to the capillary length. Most of the physicochemical mechanisms allowing some of those animals to quickly feed on nectar are not yet fully understood. This project aims to understand the physical mechanisms underlying the efficient capture of nectar by bees and hummingbirds which results from the dynamical coupling between viscous flows, capillary forces and elasticity in hierarchical soft tongues. To achieve this objective, model experiments are proposed. Mimicking hummingbirds’ tongues, I will first characterise the static closing of soft open tubes in contact with a specific amount of liquid. I will then study the dynamics when the same structure is dipped and removed from a fluid bath. In a second step, I will study the equilibrium shape and the dynamics of soft brushes and hairy surfaces dipped into a fluid bath, mimicking bumblebee’s tongue. The study of these systems will allow us to develop general physical models. The relevance of these models for describing the biological systems will be assessed by the direct comparison between the theoretical predictions and in-vivo measurements by setting the control parameters of the model systems to values compatible with the biological systems. This project will thus provide general models for the capture of viscous fluid through elastocapillary effects in some geometries inspired by biological systems. Based on the insights gained from these model experiments and the comparison with in-vivo data, optimal soft structures will be designed to passively capture precise amount of viscous fluids at a controlled rate. The BioCapSoft project will thus contribute to a better understanding of the dynamical coupling between viscous flows, capillary forces and elasticity in soft impregnated structures.

Keywords: elastocapillarity,impregnation dynamics,bio inspired slender structures
Selective CO2 conversion to renewable methanol through innovative heterogeneous catalyst systems optimized for advanced hydrogenation technologies (microwave, plasma and magnetic induction). (LAURELIN)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Alternative fuels and mobile energy sources
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Spain,Spain,Belgium,Netherlands,United Kingdom,United Kingdom,Japan
Call: International cooperation with Japan for Research and Innovation on advanced biofuels and alternative renewable fuels (H2020-LC-SC3-2020-NZE-RES-CC, 2020)
Start date: 2021-05-01
End date: 2025-04-30
Duration (months): 48.0
Total project cost (EUR): 4853053.75
EU funding (EUR): 4448838.75
Participants: 11
Project status: SIGNED

The LAURELIN is a R&D project, with a duration of 48 months, that will be focused on the optimization and improvement of CO2 hydrogenation process, to obtain methanol as renewable fuel (TRL3). Main objectives are related to the improvement of previous discussed limiting factors: selectivity, yield, and energy reqThe LAURELIN is a R&D project, with a duration of 48 months, that will be focused on the optimization and improvement of CO2 hydrogenation process, to obtain methanol as renewable fuel (TRL3). Main objectives are related to the improvement of previous discussed limiting factors: selectivity, yield, and energy requirements. The strategies adopted by LAURELIN project to achieve the planned objectives are basically the following: a) Research and development in disruptive multifunctional catalyst systems. LAURELIN is focused on methanol synthesis from selective CO2 hydrogenation. A clean process that produces water, CO and methane. b) New technologies for CO2 hydrogenation. CO2 hydrogenation with very low energy demands will be adressed by introducing three advanced synthesis technologies employing: Magnetic Induction, Non-Thermal Plasma Induction and Microwave technologies. These three technologies are suitable to employ intermittent renewable energy supply systems for selective CO2 hydrogenation, which is based on to convert renewable power energy to chemicals. One of the most remarkable aspects of the LAURELIN project will be the close collaboration with Japanese partners to share and increase knowledge on catalyst systems (mainly about high porous supports as zeolites) focused on hydrogenation processes, as well as to increase impact by fast future industrial and market deployments. LAURELIN partnership is composed by 10 partners, 8 of them are from 5 EU countries (Spain, United Kingdom, Germany, Netherlands and Belgium) and 2 partners are from Japan. Furthermore it is composed by Research Organisations, Higher Education Institutions and SME companies.

Keywords: renewable fuel,methanol,catalyst,co2 hydrogenation reaction,decarbonization
Commercialization of the most sustainable laundry detergent (EcoVel)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Germany
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2016-01-31
Duration (months): 9.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

With project EcoVel, COIN Consulting UG will realize the first laundry product generating an almost completely closed resource cycle of non-actives (monomolecular fiber, concentrated liquid in combination with solid particles for superior cleaning). The fabric, which even allows for color and fluff catching, is 100% recyclable, does not include any filling additives and has the potential (by further development) to outperform all other laundry products concerning cleaning power. Estimates based on the sustainability report from Henkel 2013 suggest a reduction of the CO2 emissions of nearly 70% by the use of the laundry wipe in comparison to regular powder detergents. The main reason for this reduction is attributable to low weight in transportation and energy efficient production without a counter stream and heating process. This eco-innovation will also have a global effect with respect to climatic issues and green economy. To market the laundry wipe it is necessary to conduct a feasibility study which includes benchmark cleaning power tests, consumer product tests, IP research and a series of production tests. The results of the feasibility study will allow us to prepare a validated business plan which is necessary for assessing finance and marketing the product through major European retailers.

Keywords: decreasing water wastage,decreasing co2 emissions
Continuous Downstream Processing of Bioproducts (CODOBIO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria,Germany,Italy,Austria,Austria,Switzerland,Sweden,Switzerland,Belgium,Slovenia,France,Netherlands,Netherlands,United Kingdom,Portugal,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-02-01
End date: 2023-08-31
Duration (months): 55.0
Total project cost (EUR): 3988839.25
EU funding (EUR): 3988839.25
Participants: 20
Project status: SIGNED

Continuous biomanufacturing is one of the grand challenges of Europe’s bio-industry. It offers a significant opportunity to boost productivity, improve competitiveness and to reduce the environmental footprint. Current progress is impaired by shortage of trained engineers and scientists, who can design and control continuous biomanufacturing processes. This Innovative Training Network (ITN) will focus on addressing the critical gaps in research training to enable advances in continuous downstream processing. An expert consortium of nine industry partners, eight universities, one research organisation, a regulatory institution and a business consultancy has developed a research and training programme to address the most urgent topics in continuous downstream processing. These are: (1) process control and modelling (including economic modelling), (2) miniaturization, scale-up and scale-down of unit operations and (3) process design and development of integrated continuous downstream processes. Furthermore, regulatory framework questions, such as comparability of product quality between batch and continuous processes will be addressed. Adding the regulatory and environmental aspects to the scientific, technological and economic approach, makes our program interdisciplinary, comprehensive and unique. Specific Ph.D. topics for 15 ESRs have been outlined. The presented research and training programme will equip the ESRs with the scientific and important transferable skills, such as IPR, entrepreneurship, data management and innovation management. The consortium’s strong track record in the management of interdisciplinary research and training will ensure effective and timely training of the next generation of leaders able to design innovative continuous facilities of the future for Europe’s bio-industries, ensuring affordability and widened access. Exposure to academic, industry and regulatory sectors will provide the researchers with unparalleled career opportunities.

Keywords: downstream processing,bioproducts,control engineering,continuous manufacturing,regulatory