Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deciphering the combinatorial signalling patterns in brain development by structural studies of axon guidance receptors and adhesive GPCRs (ComplexSignal)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Brain development relies on formation of functional neuronal circuits. This requires coordinated migration of embryonic neurons and their cellular processes such as axons to the target regions and their selective connections with synaptic partners. The migration of neurons and axons is mediated by guidance cues. Combined interactions of multiple guidance cues with their receptors direct neurons and axons to their final destinations. So far our understating is limited to the effect of individual cues, which result in attractive or repulsive responses. How multiple cues influence neuron and axon migration remains elusive. In addition, interactions of multiple cues and receptors are poorly understood. Our group recently elucidated the structure of an octameric super-complex fragment consisting of FLRT proteins, adhesion GPCRs Latrophilin and guidance receptors Unc5. In this project, we will aim at elucidating the full length (including the transmembrane domains) structure of the super-complex to reveal the molecular details of the interactions. Further analysis of structure-function relationship of the super-complex will, for the first time, address how modular architecture of these medically important receptors influence their signaling functions. Expertise of the host, capacity of the researcher, multidisciplinary approach of the proposal and well-planned implementation and risk mitigation strategies will ensure successful completion of the project. The results will enhance competence of the researcher; collaboration opportunities and competitiveness of the host and contribute to the excellence of European research.
Mineral wool waste back to loop with advanced sorting, pre-treatment, and alkali activation (WOOL2LOOP)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Innovation actions
Countries involved: Finland,Finland,Sweden,Slovenia,Belgium,Poland,France,Netherlands,Netherlands,Denmark,Portugal
Call: Raw materials innovation for the circular economy: sustainable processing, reuse, recycling and recovery schemes (H2020-SC5-2018-2, 2018)
Start date: 2019-06-01
End date: 2022-11-30
Duration (months): 42.0
Total project cost (EUR): 6716690.5
EU funding (EUR): 5294937.86
Participants: 16
Project status: CLOSED

Mineral wool within construction and demolition waste (CDW) is considered largely unrecyclable. It is formed at a rate of 2.5 Mt/year and although it is only 0.2 % of total CDW, it requires disproportionally large space due to low density. The WOOL2LOOP project aims to close this material loop by introducing novel technology and value chain to CDW sorting, pretreatment, and processing. The quality of sorted mineral wool is upgraded by comparing and combining the following approaches: pre-demolition audit, robotized demolition and sorting, novel on-site analysis with time-gated Raman spectroscopy, and smart demolition practices. Pre-treatment involves logistical considerations and milling of the mineral wool waste to sufficiently small particles. Processing utilizes alkali-activation (i.e., geopolymerization) technology to convert reactive silica and alumina of the mineral wool into new building material products. Alkali-activation in this context is a completely new approach and it enables to diversely adjust the resulting material properties. Therefore, a broad selection of products were selected for WOOL2LOOP, ranging from relatively low to high value products: hollow core and pavement slabs, facade elements, acoustic panels, dry concrete, floor screed and 3D-printing equipment, for instance. All the required technologies and product manufacturing cases will be demonstrated in large-scale pilots with a wide geographic coverage within the EU. The consortium includes several leading large construction material enterprises and innovative SMEs to cover the whole value chain. Safety, health, environmental, and economic aspects are considered throughout the project. According to the preliminary calculations, there is a strong business potential in the WOOL2LOOP concept. Finally, the constantly increasing landfilling costs (approx. 250 M€ for mineral wool in the EU) create a clear economic driver for the project.

Keywords: mineral wool,construction and demolition waste,waste separation,geopolymer,alkali activation,additive manufacturing,alkali activated concrete,construction industry,alternative raw materials
New Technology for Multi-Axial, Slim and High Performance Timber Structures (TS3.0)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Buildings are responsible for 36% of total EU emissions of carbon dioxide (CO2). Concrete has been an excellent choice in the buildings construction, nevertheless is responsible for emitting 500 kg of CO2 per 1m3 of concrete used. Triggered by these facts EU has already set binding targets for CO2 reduction for which alternative safe techniques to build buildings in a carbon neutral manner will be crucial. Timber is a structural solution that has a much lighter carbon footprint than functionally equivalent concrete systems since it absorbs and stores 1 ton of CO2 per 1 m3 of timber. Nevertheless, all known timber building systems allow only slabs with a uniaxial load bearing action. Thereby, in comparison to normal reinforced concrete slabs, timber slabs are often thick, expensive and complicated to build, since there is no efficient connection technology to rigidly connect timber slab elements to each other. TS3.0 technology represents the next generation of timber constructions aiming to realise typical skeleton buildings using only timber. We offer the possibility to build beams and slabs in any length and size and our proprietary butt-joint bonding technology allows the bonding of timber parallel to the grain. Therefore, timber beams by almost any length or plates of almost any dimension can be produced (i.e. rigid walls, floors or shells of any shape). Through the project we expect to reach €26.7 million revenues five years after its commercialization. Phase 2 will require an investment of close to €2 million, which will present a Cumulative Return of Investment of 5.9.

Keywords: timber multi axial load bearings,timber slim slabs,timber structures,novel construction technology,construction industry
PHOto-induced Energy flow in Bio-inspired molecular circuits probed with Ultrafast two-dimensional Spectroscopy (PHOEBUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2018-09-30
Duration (months): 36.0
Total project cost (EUR): 244269.0
EU funding (EUR): 244269.0
Participants: 2
Project status: CLOSED

Solar energy is forecast to cover an important fraction of the world’s energy necessities over the next century. The energy captured from sunlight will be used to drive photovoltaic cells or to produce solar fuels, thus Scientists must learn how to harvest, transfer and store it efficiently. In this framework, the PHOEBUS project aims at providing the design of innovative chemical structures (molecular circuits) that can control in sophisticated ways the flow of excitation energy. The project focuses on bio-inspired molecular circuits, where several light-absorbing molecules are linked together to form antenna systems displaying ultrafast electronic energy transfer (EET). We aim to identify and understand how coherent effects can direct, control, and optimize energy flow after photo-excitation. PHOEBUS will answer to the following questions: (i) does coherence radically change excitation transport compared to incoherent hopping of excitation? (ii) how can we design chemical structures that use coherence in light harvesting? Two-dimensional electronic spectroscopy (2DES) is the ideal experimental tool to track EET and unveil coherent couplings in multi-chromophoric complexes. This optical technique is at the frontier of ultrafast spectroscopy. We will develop a 2DES apparatus using sub-10fs optical pulses and we will use it to determine the quantum-chemical rules guiding ultrafast EET in these innovative systems. The combination of femtosecond nonlinear spectroscopy, quantum chemical calculations, and chemical synthesis will contribute to the ultimate ambitious goal of changing the way artificial light-harvesting technologies are designed.

Keywords: energy transfer control molecular citcuits ultrashort pulses bidimensional electronic spectroscopy solar harvesting lartificial complexes bio inspired
Safe and COnnected aUtomation in road Transport (SCOUT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Spain,Germany,Germany,Germany,Germany,Germany,Italy,Italy,Germany,Belgium,France,Netherlands,United Kingdom
Call: Safe and connected automation in road transport (H2020-MG-2015-Singlestage-B, 2015)
Start date: 2016-07-01
End date: 2018-06-30
Duration (months): 24.0
Total project cost (EUR): 998342.5
EU funding (EUR): 998342.5
Participants: 14
Project status: CLOSED

The project "Safe and COnnected aUtomation in road Transport" (SCOUT) aims at identifying pathways for an accelerated proliferation of safe and connected high-degree automated driving in Europe, taking into account user needs and expectations, technical and non-technical gaps and risks, viable business models as well as international cooperation and competition. The analysis will start from a thorough consideration of the concerns and expectations from the perspectives of users, suppliers of the technology and experiences from projects and field tests. Alternative strategies for the implementation of automated driving will then be developed, under due consideration of different innovation cycles in the related industries (automotive, telecom, infrastructure, services) and the pending challenges regarding framework conditions (legal, testing & validation, safety & security). With regard to the perceived use cases for connected automation in road transport, technical und non-technical gaps and risks for the implementation will be identified, assessed and ranked. In parallel, sustainable business models will be identified with particular emphasis on the role of digitization, connectivity and data-driven business cases. Advice for policies and regulatory frameworks for safe and connected automation will then be derived on the basis of the aforementioned analyses with the support of a network of relevant stakeholders, and subsumed into a common roadmap aiming to implement the formulated vision for "Safe and connected automation in 2030". The results will be communicated to and discussed with policymakers, stakeholders and the general public at a multitude of opportunities. International trends and results of European funded projects will be closely monitored and reflected in the strategy development process.
Deep-sea Sponge Grounds Ecosystems of the North Atlantic: an integrated approach towards their preservation and sustainable exploitation (SponGES)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Germany,Germany,Spain,Italy,Sweden,Norway,Netherlands,Netherlands,Netherlands,United States,Canada,United Kingdom,United Kingdom,Portugal,United Kingdom,Portugal,Portugal
Call: Improving the preservation and sustainable exploitation of Atlantic marine ecosystems (H2020-BG-2015-2, 2015)
Start date: 2016-03-01
End date: 2020-12-31
Duration (months): 58.0
Total project cost (EUR): 10275365.25
EU funding (EUR): 9994302.75
Participants: 25
Project status: CLOSED

The objective of SponGES is to develop an integrated ecosystem-based approach to preserve and sustainably use vulnerable sponge ecosystems of the North Atlantic. The SponGES consortium, an international and interdisciplinary collaboration of research institutions, environmental non-governmental and intergovernmental organizations, will focus on one of the most diverse, ecologically and biologically important and vulnerable marine ecosystems of the deep-sea - sponge grounds – that to date have received very little research and conservation attention. Our approach will address the scope and challenges of EC’s Blue Growth Call by strengthening the knowledge base, improving innovation, predicting changes, and providing decision support tools for management and sustainable use of marine resources. SponGES will fill knowledge gaps on vulnerable sponge ecosystems and provide guidelines for their preservation and sustainable exploitation. North Atlantic deep-sea sponge grounds will be mapped and characterized, and a geographical information system on sponge grounds will be developed to determine drivers of past and present distribution. Diversity, biogeographic and connectivity patterns will be investigated through a genomic approach. Function of sponge ecosystems and the goods and services they provide, e.g. in habitat provision, bentho-pelagic coupling and biogeochemical cycling will be identified and quantified. This project will further unlock the potential of sponge grounds for innovative blue biotechnology namely towards drug discovery and tissue engineering. It will improve predictive capacities by quantifying threats related to fishing, climate change, and local disturbances. SponGES outputs will form the basis for modeling and predicting future ecosystem dynamics under environmental changes. SponGES will develop an adaptive ecosystem-based management plan that enables conservation and good governance of these marine resources on regional and international levels.

Keywords: sponge grounds,vulnerable marine ecosystems,habitat mapping,biogeography and connectivity,goods and services,distribution,food web and ecosystem models,genomics,biogeochemistry
antibiotic RESistance and mObile genetic eLements dissemination in enVironmEntal conditions (RESOLVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-08-01
End date: 2018-07-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Multidrug-resistant bacteria are spreading worldwide and present a serious public health issue. Bacterial resistance has to be addressed with a global approach connecting human health with animals and the environment. Mobile genetic elements (MGEs) such as bacterial plasmids, transposons or cassettes of integrons, as frequent carriers of antibiotic resistance genes (ARGs), play an important role in the global spread of ARGs among bacterial communities. My research aims to understand how environmental parameters could modulate the dynamics of MGEs involved in ARG dissemination and contribute to the global burden of antibiotic resistance. For this aim, I will use a global approach that merges medical and molecular microbiology, microbiota studies and genomic studies (employing next generation sequencing techniques). Single monospecies-biofilms as well as natural biofilms grown from wastewaters will be used as models of investigation. The proposed research will profoundly improve my knowledge in molecular and medical microbiology techniques to study MGEs associated with antibiotic resistance. This project will be pivotal for my personal development to become an independent researcher and will provide me with the unique opportunity to work with experts in the field of MGEs, antibiotic resistance and the environment. I will be exposed to novel ideas and input from renowned researchers belonging to scientific disciplines unrelated to my background that will have a strong impact on my personal and scientific development. Furthermore, I aim to establish a series of lectures and seminars for the general (research) community to further increase awareness of the importance and relevance of the global fight against antibiotic resistance.

Keywords: antibiotic resistance,mobile genetic elements,dissemination,environment,expression induction
Rydberg Quantum Simulators (RYSQ)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Germany,Germany,Germany,Italy,Germany,Switzerland,France,France,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom
Call: Quantum simulation (H2020-FETPROACT-2014, 2014)
Start date: 2015-03-01
End date: 2018-02-28
Duration (months): 36.0
Total project cost (EUR): 4695000.0
EU funding (EUR): 4383000.0
Participants: 18
Project status: CLOSED

Quantum Simulators provide new levels of understanding of equilibrium and out-of-equilibrium properties of many-body quantum systems, one of the most challenging problems in physics. The main objective of the RYSQ project is to use Rydberg atoms for quantum simulations, because their outstanding versatility will allow us to perform a great variety of useful quantum simulations, by exploiting different aspects of the same experimental and theoretical tools. By implementing not only one but a whole family of Rydberg Quantum Simulators, the project will address both the coherent and incoherent dissipative dynamics of many-body quantum systems, with potential applications in the understanding and design of artificial light harvesting systems, large quantum systems with controlled decoherence, and novel materials. This will be achieved by building upon a novel generic approach to quantum simulation, where Rydberg atoms allow both digital (gate) and analog (interaction) simulations. In addition to solving problems in fundamental and applied science, the project will build up core competences for quantum science and technologies in mainstream engineering, by using innovative methods for communication, dissemination and exploitation of results. In summary, RYSQ plans (A) to develop a collection of novel experimental and theoretical tools for Rydberg quantum simulators, and (B) to use them as a basis for implementing many important applications of quantum simulations. The project is structured in such a way to allow for efficient exchanges within the consortium, and to maximize the overall outcome of the work.

Keywords: quantum technologies quantum simulators rydberg atoms
Profiling of tumour cells in blood for personalized treatment of metastatic cancer (CYTOPRO)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Denmark
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-10-01
End date: 2015-10-31
Duration (months): 1.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Challenge Up to 40% of patients diagnosed with metastasised breast cancer fail to respond to treatment. Cancer cost the EU €126bn in 2009 incl. productivity losses of €42.6bn and lost working days worth €9.43bn. 3.2m citizens in EU lose their lives to cancer each year. Solution Circulating Tumour Cells (CTC) are cells that have shed into the vasculature from a primary tumour and circulate in the bloodstream. CytoTrack has developed a breakthrough technology that can identify and isolate metastatic cancer cells from a blood sample. It is superior to all other technologies due to a very efficient and non-biased detection principle and an integrated feature to isolate individual cells for characterisation. It is the perfect tool to be used together with new single cell characterisation assays currently being introduced on the market. Impact The innovation will provide an effective, accurate, fast and cheap characterisation of CTCs in a single device, enabling pathologists and clinicians worldwide to deliver personalised medicine and cancer treatment targeted the exact mutation of the individual patient’s cancer form. CytoTrack expects that the innovation can reduce cancer deaths by 10%. In EU alone this would reduce the productivity loss with >€10bn per year and treatment costs with >€12.5bn. Project This phase 1 project will investigate 1) collaboration with labs, 2) regulatory conditions for first markets, and 3) prepare for clinical trials. The overall innovation project will enable CytoTrack to be the first on the market to offer an integrated diagnostic platform for routine isolation and characterisation of metastatic cancer cells in blood, enabling personalised therapy targeting the exact profile of the cancer form. Customers and market The CTC technology market was $3.7bn in 2013, growing 18.9% annually. The research market is a first step in gaining a strong foothold before approaching the much larger, but also more challenging, clinical market.

Keywords: integrated diagnostic platform,personalised therapy,cytotrack ct11