Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Fostering cross-border knowledge exchange and co-creation on sustainable soil and farm management (Soil-X-Change)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Hungary,Slovakia,Poland,Austria,Spain,Slovenia,Bulgaria,Germany,Italy
Call: Broaden EIP Operational Group outcomes across borders by means of thematic networks to compile and share knowledge ready for practice (HORIZON-CL6-2023-GOVERNANCE-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2105999.29
EU funding (EUR): 1999097.5
Participants: 13
Project status: SIGNED

The proposed project: Initiative of Fostering cross-border knowledge exchange and co-creation on sustainable soil and farm management (Soil-X-Change) will help to connect farmers, actors, policy makers, projects, and initiatives to speed up innovation and promote faster, wider co-creation and transposition of innovative solutions into practice. It will contribute to effective AKIS by intensifying thematic cooperation between researchers, farmers, and other stakeholders in the EU. Soil-X-Change will also contribute to the green transition, smart agriculture, climate-neutrality, and sustainability areas, as well as enhancing and exchanging the knowledge of the main actors. Soil-X-Change, initiated by EIP-AGRI Operational Group practitioners (OGs), reflects the needs of 151 direct partners. It will collect, combine, harmonise, analyse and integrate the results and data product developed by the different EIP-AGRI OGs and the project partners. Soil-X-Change will disseminate and share innovative practices across 9 member countries. Furthermore, the Soil-X-Change project will bring together EIP OGs and key stakeholders working on sustainable soil and farm management to create an EU-wide network, share knowledge, and introduce ready-to-use practices that will enable farmers to make the right decisions related to agricultural production practices. At the end of the project the extended knowledge and innovative ideas of member and non-member OGs will widen the scope of their activities and showcasing their result to an increased number of stakeholders and farmers in an international environment and network across EU countries. Soil-X-Change will use a bottom-up approach (farmers to OGs) and will reinforce and share practical knowledge using the main dissemination channels suitable for farmers and practitioners.

Keywords: eip operational groups,soil management,climate change,knowledge uptake and deployment
Astrocyte dopamine D1 receptor signaling in depression (D1-Glia)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Slovenia
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 171399.36
EU funding (EUR): 171399.36
Participants: 1
Project status: CLOSED

Major depressive disorders (MDD) represent a global challenge. Although many recent initiatives have resulted in new antipsychotic drugs, their efficacy is not optimal. One possible reason for this is that the prevailing paradigm for drug development is based on the neuron-centric view of how the central nervous system (CNS) copes with diseases. In the fellowship, I will study neuroglia, the nonneuronal cells responsible mainly for maintaining homeostasis in the CNS. Failure in the function of these cells can set the course for neurological conditions, including psychiatric diseases and MDD. Thus, targeting neuroglia has recently been viewed as a new translational ground for drug development. The present proposal is therefore based on our understanding of the potential role of neuroglia in brain disease. One of the major neurotransmitters, dopamine, is known to play an important role in MDD. I will examine the regulation of astrocytes, a major type of neuroglia, by dopamine. Based on the state of the art, I hypothesise that astrocytic dopamine D1 receptor signalling may be involved in the pathophysiology of MDD. Through innovative methodological approaches I will study the regulation of astrocytic D1 receptor signalling at the cellular level in an experimental model of MDD. Moreover, this project will explore D1 signalling in vivo to validate the results obtained on isolated cells. The proposed research will provide a new framework that includes astrocytes and the mechanisms underlying the dopaminergic modulation in depression. This will afford novel cellular targets for treatment of MDD associated with dopamine D1 receptor signalling. In addition, a comprehensive two-way transfer of knowledge is envisioned to bring together competences and experiences necessary for the proposed research. The fellowship will facilitate my career development and enable me to get established in the field.

Keywords: astrocytes,neuroglia cells,dopamine,dopamine,dopamine receptor,dopamine signaling,dopamine d1 signaling,cell culture,fret,electrophysiology study,drug addiction,major depressive disorder
Investigating CD1d-dependent neuronal activation of natural killer T cells and its impact on neurodegenerative disease (NKT-in-NDD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 247553.28
EU funding (EUR): 247553.28
Participants: 1
Project status: SIGNED

Neurodegenerative diseases (NDDs) are a broad category of neurological maladies, typically characterized by cognitive decline and motor deficits. NDDs affect over 55 million individuals worldwide, a number that is expected to triple over the following decades. Until recently, the brain was considered immune-privileged, but emerging scientific advancements in the field of neuroimmunology show that immune cells reside within and even infiltrate the central nervous system (CNS). Despite ever-growing evidence illuminating the critical interplay between the nervous and immune system in maintaining neural homeostasis, research efforts have been limited in this scope. We recently identified that an immune-related gene, CD1d, is expressed by neurons. CD1d is recognized by natural killer T (NKT) cells, generally inducing an immunosuppressive response. We found that selective knockout of CD1d in neurons led to NDD development in mice. We also gathered biocomputational evidence from both human and mouse brains showing that neurons near the choroid plexus have the highest CD1d expression. These preliminary findings inspired the NKT-in-NDD project with the following three aims: (1) To determine whether CD1d-expressing neurons can sufficiently activate NKT cells (2) To examine the impact of CD1d-dependent neuronal activation of NKT cells on inflammatory conditions and NDDs (3) To verify whether CD1d is expressed by neurons localized near the choroid plexus As an expert in neurological maladies, I will join forces with Prof. Shohreh Issazadeh-Navikas, a leader in the neuroimmunology field, to tackle this interdisciplinary project at the Biotechnology Research & Innovation Centre (BRIC) at the University of Copenhagen (UCPH) in Denmark. Together, we will address various gaps in the fields of immune cell biology, neuroimmunology, and neurodegeneration. The neuroimmune insight developed from this project may expand current treatment options for NDDs.

Keywords: neuroimmunology,neuroinflammation,neurodegeneration,natural killer t cells
Exploring the induction of trained immunity by anti-infective antibodies delivered directly to the respiratory tract, as a protective response against respiratory infection (TI-LAB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 3
Project status: SIGNED

Therapeutic antibodies (Abs), have become crucial drugs in modern medicine, showing success in treating various diseases, including the global COVID-19 pandemic. Although anti-infective Abs are usually administered parenterally, recent findings demonstrated that local administration into the respiratory tract of an Ab neutralizing Pseudomonas aeruginosa (Pa) not only blocks primary infection but also offers prolonged protection against secondary infections. However, the molecular mechanisms supporting the immunomodulatory features of the Ab and establishment of long-lasting protection remain unknown. Preliminary data from the host laboratory indicate that murine macrophages primed with Ab+Pa immune complexes (ICs) display an antimicrobial pro-inflammatory phenotype, further enhanced after exposure to Toll-like receptor ligands, suggesting the induction of immune memory. This capacity termed trained immunity (TI) depicts a type of immune memory within innate immune cells that recall previous epigenetically-encoded information under heterologous stimulation. Using a combination of molecular, metabolic, and epigenetic approaches in conjunction with omics-based techniques, TI-LAB (Trained immunity Induced in the Lungs by therapeutic AntiBodies) will define the capacity of ICs to induce TI. Furthermore, TI-LAB will provide a detailed analysis of the intracellular signaling pathways involved in IC-mediated TI. Finally, the protective effects of IC-mediated TI will be assessed using an in vivo model of respiratory infection. This proof of concept will be extended to other respiratory pathogens to determine if TI induced by ICs is a conserved mechanism across pathogens. Overall, our findings will reveal a new function of anti-infective Abs in immune memory and reprogramming of the innate immune system, which should help design new treatments against respiratory pathogens.

Keywords: anti infective antibodies trained immunity immune complexes inhalation respiratory infection
Climate and Contemporary Transformations of Vernacular Architecture - Interaction, Effects and Perspectives (CLIMATE-Arch)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1986871.5
EU funding (EUR): 1986871.5
Participants: 1
Project status: SIGNED

The majority of the world’s population still live in vernacular buildings which are based on local knowledge. Climate has a significant impact on the use and evolution of local building techniques and building design. CLIMATE-Arch will focus on the processes involved in the transformation of local building techniques caused by climate and climate change. A wide range of local material resources and natural environmental conditions, and the effects of climate change, produce various kinds of technical adaptations. CLIMATE-Arch will explore these transformations and their drivers at the level of both building technology and building design, focusing on two regions in Eurasia that use a range of local building technologies. Most previous research on the impact of climate change has taken a mono-disciplinary approach, in the main not considering the processes responsible for the evolution and transformation of buildings, which principally stem from the inextricable link between material and environmental conditions. CLIMATE-Arch will break new ground by examining the factors that trigger vernacular transformation through a climate lens, combining climate research and the disciplines of architecture, engineering, natural environmental sciences and sociology. As the project will examine vernacular changes expected as a result of predicted climate change, the results will remain relevant long after the conclusion of the work. In the long term, the research of CLIMATE-Arch will be indispensable both for producing accurate scientific accounts and for establishing standards to balance conservation and modernization. The PI’s extensive multi-disciplinary scientific experience makes him eminently qualified to lead CLIMATE-Arch and to coordinate the team of post-docs, PhD students and research assistant based at the Austrian Academy of Sciences’ Institute for Social Anthropology (ISA).

Keywords: rural studies,vernacular architecture
Selenium Containing Rupturing Dendritic Prodrugs for Therapeutic Applications (RUPTURE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-01
End date: 2025-01-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 2
Project status: CLOSED

Elevated rates of reactive oxygen species (ROS) have been detected in almost all cancers, where they promote many aspects of tumour development and progression. The radical generated, the location, as well as the local concentration, are essential for the cellular functions of ROS in cancer. Among redox modulating compounds, selenium derivatives have gained substantial attention due to their promising chemotherapeutic potential, which result from selenium’s ability to act as a pro-oxidant at high dosage. This proposal is intended to develop novel therapeutic agents based on selenium-containing dendrimers, which act as precision carriers with unparalleled structural perfection. These agents, with a plethora of internally queued selenium-selenium bridges will be activated upon the rupturing of the dendritic carriers by external stimuli. It is herein envisioned that RUPTURE can rise to the challenge, acting as cutting-edge prodrugs that will fine-tune intracellular ROS signalling to effectively deprive cells of ROS-induced tumour-promoting events, thereby tipping the balance to ROS-induced apoptotic signalling.

Keywords: nanotechnology,dendrimer,rupture,selenium,ros,cancer
Scalable Continuous Variable Cluster State Quantum Technologies (CLUSTEC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Denmark,Czechia,Germany,France,Switzerland
Call: Basic Science for Quantum Technologies (RIA) (HORIZON-CL4-2021-DIGITAL-EMERGING-02, 2021)
Start date: 2022-11-01
End date: 2026-10-31
Duration (months): 48.0
Total project cost (EUR): 2994543.75
EU funding (EUR): 2994543.75
Participants: 9
Project status: SIGNED

Continuous variable (CV) quantum technologies have in recent years made significant impact on the fields of quantum communication, sensing, and computing, as signified by the detection of gravitational waves and demonstration of quantum advantage via Gaussian boson sampling. Moreover, the recent generation and manipulation of CV cluster states, comprising thousands of entangled modes, have direct implications for future developments of scalable CV quantum computing and networking systems. In CLUSTEC, we will pursue an interdisciplinary approach to unfold the full potential of CV cluster state technology by making conceptual and technical breakthroughs along three different directions. First, we will develop two complementary optical platforms for scalable generation of massive CV cluster states of different entanglement topologies and generation of hardware efficient error-correcting codes. The two systems will be based on a well-established low-loss fiber platform and the emerging, highly promising integrated photonics platform of thin-film Lithium Niobate. Second, we will develop and test radically new measurement-induced CV quantum computational and networking protocols and algorithms with certified quantum advantage and real-life applications. Third, we will explore and develop, theoretically and experimentally, novel quantum error-correcting CV protocols and technologies that facilitate the realization of practical fault-tolerant quantum technologies for quantum computing, communication and sensing with true scalability potential. With these activities, CLUSTEC will create a new path towards scalable quantum technologies and accelerate the development of practical quantum technologies with potentially radical impact on European society and economy. The results will pave the way for industrial uptake and exploitation in the near and long term, and in turn support the development of European leadership and autonomy in emerging strategic technologies.
Reslient Rapid ReconfiGurable pROdUction Process chains (R3GROUP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: France,Greece,Spain,Austria,Portugal,Germany,Italy,Denmark,Romania,Slovenia,Luxembourg
Call: Rapid reconfigurable production process chains (Made in Europe Partnership) (IA) (HORIZON-CL4-2022-TWIN-TRANSITION-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 11904020.41
EU funding (EUR): 9124528.5
Participants: 25
Project status: SIGNED

Covid-19 has shown that unpredictable events can disrupt supply chains, demand, and induce work restrictions, which can be detrimental to the manufacturing sector, significantly affecting growth. Especially, when medium or high-volume manufacturing is considered, resilience can only be achieved through rapid reconfigurability and digitalization. Rapid reconfigurability must be addressed in all production levels, ranging from the factory to the machinery and to each individual process step, as well as the interaction with the supply chain. The objective of R3GROUP is to develop and demonstrate resilience strategies for reconfiguration. The project will carry out industrial demonstrators in diverse manufacturing sectors (automotive, fabricated metal products, rubber and plastics, wearing apparel, home appliances) facing various reconfiguration issues (scale up or down, introduction of new suppliers, accommodation of multiple product variants, resilience to unforeseen events), engaging end-users operating with different business models (B2B, B2C) and on different positions in the value chain (OEM, Tier 1). R3GROUP will follow the 6 reconfigurability principles to develop technologies in 5 pillars towards resilience through reconfigurability: i) release an AAS-enabled platform for horizontal and vertical integrability for reconfigurability; ii) develop production tools and technologies, through the reconfigurable machine tool concept; iii) deploy a digital toolkit supporting rapid evaluation of reconfiguration impacts, using multi-level digital twins; iv) integrate innovative tools to capture the trigger for reconfiguration that provide awareness on the status of the rest of the value chain (supply chain, market); v) multi-level monitoring, control, and quality assessment to mitigate the reconfiguration impact. Finally, R3GROUP will develop human-centred solutions and put special focus on reskilling to support the adoption of novel technologies.
Delineating PLATElet-induced sex-specific responses in Calcific Aortic Valve disease using 3D-bioprinting and proteomics. (PlateCAV-3D)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2028-04-30
Duration (months): 36.0
Total project cost (EUR): 426533.76
EU funding (EUR): 426533.76
Participants: 2
Project status: SIGNED

Calcific aortic valve disease (CAVD) is an increasing global health burden. Once symptomatic and untreated, CAVD confers a 2-year mortality rate of ~50%. Crucially, costly and highly specialised valve replacement surgery remains the only treatment. Additionally, while male and female patients present with calcific or fibrotic tissue degeneration, respectively, experimental studies mostly use male models. The rising disease burden, lack of understanding of differential pathophysiological mechanisms underlying CAVD onset and progression, and inequality in accessing surgical intervention impose the need to uncover novel therapeutic targets to delay disease development. Haemostatic alterations, including platelet activation, are implicated in CAVD, and may particularly compromise patients with bicuspid vs. tricuspid valves. Endothelial-to-mesenchymal transition of valvular endothelial cells is a hallmark of CAVD onset and potently induced by platelet-derived mediators such as TGF-β, suggesting the direct involvement of activated platelets. The differential platelet-mediated mechanisms underlying both the valve morphology- and sex-specific disease pathophysiology remain elusive. We will perform unbiased global proteomics to identify novel platelet-derived mediators in the onset of CAVD. These mediators will be used to induce CAVD in a biologically relevant, sex-specific 3D bioprinted in vitro model. By combining histopathology, imaging, proteomics, and bioinformatics, PlateCAV-3D will characterise the contribution of platelets to the onset of CAVD and infer valve morphology- and sex-specific disease trajectories to uncover novel therapeutic targets. Identification of patient-specific therapeutic target candidates provides the opportunity to design clinical trials to decelerate disease onset/progression and ultimately diminish the need for surgical intervention, globally decreasing health care costs, and eradicating the inequality in access to interventional therapies.

Keywords: calcific aortic valve disease platelets 3d bioprinting endothelial to mesenchymal transition