Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
An Innovative and Sustainable Spray Drying Technology (SpeeDrying)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

This proposal aims to widen the competences and skills of a young, excellent and ambitious researcher (Loredana Malafronte) by advanced training at one of the most innovative food engineering groups located at ETH - Swiss Federal Institute of Technology Zürich, Switzerland. The training will develop Malafronte's personal, technical and entrepreneurship skills, as well as widen her network of international contacts both in academy and industry. The research project that will be carried out aims to develop a sustainable and innovative spray drying technology for production of highly functional powders from a liquid feed by combining electromagnetic (microwave and/or infrared) and convective heating. The advanced spray-drying technology is expected to improve drying efficiency in food, pharmaceutical and chemical industries, reduce energy consumption, and enable manufacture of flexible dryers and innovative dry products with high functionality. This work will build on knowledge developed by Malafronte during her PhD work and it will give to the candidate possibilities to learn a new scientific approach and how to develop more complex and innovative processes. A tailor processing approach, developed by Prof. Windhab, the main supervisor at ETH, will be used to extract Process-Structure Functions (PSF) and Structure-Property Functions (SPF) from the molecular- to macro-scale during electromagnetically assisted spray-drying. In addition to skills in conducting research, Malafronte will learn how to manage projects, communicate results effectively and commercialize research. This project will give Malafronte the possibilities to pursue a research career in Europe.

Keywords: spray drying,electromagnetic heating,particle formation,modeling,drying kinetics,encapsulation,powder functionality
Aerodynamic upgrade of Surface Air Cooled Oil Cooler (SACOC) (SACOC)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Spain,United States
Call: Aerodynamic upgrade of Surface Air Cooled Oil Cooler (SACOC) (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-04-01
End date: 2021-09-30
Duration (months): 30.0
Total project cost (EUR): 648106.25
EU funding (EUR): 552606.25
Participants: 3
Project status: CLOSED

The next generation of Geared Turbofan, like the UHBR concept, requires larger heat exchangers to dissipate the heat generated in operation. The main aims of this project are: - to develop a predictive numerical methodology to assess the performance of any new air heat exchanger concept. The methodology will be validated against an experimental database to be acquired in this project. - to evaluate numerically but also experimentally new concepts like SACOC without fins to improve the current SACOC technology, resulting from the better understanding of physical phenomena.

Keywords: heat transfer,acoustics,uhbr
Market Power and Secular Macroeconomic Trends (MARKET POWER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-06-01
End date: 2025-05-31
Duration (months): 60.0
Total project cost (EUR): 1564000.0
EU funding (EUR): 1439000.0
Participants: 2
Project status: SIGNED

In the last four decades, there have been a number of significant secular trends in the advanced economies around the world. Wage inequality has risen sharply, and most of the wage gains have been appropriated by the top 1%. In addition, labor market dynamism and new startups have declined, the labor share of total output has fallen, low skilled wages have stagnated, and there has been reallocation of production from small to superstar firms. During the same four decades, there has also been a sharp secular increase in market power. Firms set higher prices, profit rates are higher, and scale economies are up. In this proposal, I address the question whether these secular trends are related. Specifically, I ask whether the rise of market power has caused these profound macroeconomic changes. The objective is to uncover economic mechanisms that help understand this fundamental transformation and the implications for efficiency and welfare. I propose to investigate both the causes of the rise in market power and its macroeconomic consequences. I distinguish between causes that stem inherently from the market structure (such as antitrust enforcement and Mergers & Acquisitions) and those that result from technological change (economies of scale, intangible assets, and network externalities). Methodologically, this research proposal aims to contribute to the literature on three fronts: 1. the measurement of markups, 2. to derive theoretical results linking market power and macroeconomic consequences, 3. to estimate and quantitatively evaluate these models. The close link between the macroeconomic consequences and the causes of market power renders this a research proposal at the intersection of macro/labor, industrial organization and law & economics. The objective is to inform the policy debate: how to keep market power under control in order to remediate its macroeconomic consequences that were hitherto considered independent.
Automate ISO-certified DNA screening platform to enhance the global food supply chain (BEAMitup)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-08-01
End date: 2022-07-31
Duration (months): 24.0
Total project cost (EUR): 3571000.0
EU funding (EUR): 2499700.0
Participants: 1
Project status: CLOSED

Food recalls, costly mitigation measure following the evidence of contaminated, adulterating or counterfeiting foods are daily. It can cost several milions to take back the food company and cause severe damages to the brand. Lab tests, detecting food contaminants can take up to seven days and are thus not compatible with fresh-food processes. The BEAMit-up platform that will bring the global food supply chain to the upper level of safety is composed of a hardware, capsules and a cloud solution. The capsule integrates a rapid DNA screening, developed and patented by SwissDeCode. Placed at the point-of-care, the BEAMit-up platform will certify the presence of pathogens or identify pork in beef meat in only 30 minutes. An ISO 17025 certificate will be released by SwissDeCode for each test. We will validate the BEAMit-up platform early access programs: We supply hardware and capsules to the customer who will perform a pre-defined number of tests per week. We will investigate the presence of Halomonas, milk proteins, and pork. We will also use the platform for GMO corn detection. SwissDeCode estimates a positive EBITDA at 5 years of €6.8M with a company growth to 200 employees. To tackle the SARS-CoV-2, rapid and accurate detection methods are needed. Since the beginning of March, SwissDeCode collaborates with The Genova Hospital to extend the core technology to the detection of the virus. Preliminary tests were sent to the virology labs of the hospital and will be tested with patient samples. With the support of the EC, SwissDeCode can bring this new test to the hospital within few months only.

Keywords: dna screening,automation,coronavirus detection
Explaining Politicians' and Voters' Behavior (POLITICALMIND)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-10-01
End date: 2021-07-31
Duration (months): 70.0
Total project cost (EUR): 1375869.0
EU funding (EUR): 1375869.0
Participants: 1
Project status: CLOSED

Theoretical models and empirical studies in political economy aim at explaining both the beliefs and the choices of voters and politicians, so as to assess their impact on economic policy. In particular, a recent literature has recognized the crucial relevance of the identity of politicians in taking policy decisions and ultimately in shaping the fate of their country (Besley 2005; Jones and Olken 2005). In this project, we will address two neglected elements in the existing literature: the role of political parties as organizational structures that shape political careers (i.e., who gets on top in democracies); and the nature of social preferences, personality traits, and cognitive biases in understanding the beliefs and the choices of both politicians and voters. To make this research agenda operational, we will cover a set of related topics, which will range from the analysis of networks and career trajectories within political parties to the impact of emotions on protests, from the cognitive biases and personality traits of elected officials to the impact of violence on long-term political attitudes, from cognitive dissonance in voting to the contamination between political and judicial elections. From a methodological perspective, the project will tackle these issues empirically by combining the collection of original individual-level datasets (mainly in Italy) with the implementation of design-based identification strategies (Angrist and Pischke 2010). In particular, based on a careful institutional analysis of the topics under investigation, the empirical strategies will range from randomized controlled trials to instrumental variables, from laboratory experiments with elected officials (i.e., taking politicians to the lab) to regression discontinuity designs.
Integrated Pedestrian Behavior Modeling under Normal and Evacuation Situations (IPBMNES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

In order to understand the nature of complex and collective dynamics of pedestrians during normal and evacuation situations, mathematical models and simulation tools are essential. Compared to vehicular flows, pedestrian movements show a more complex behavior, mainly because they are essentially two-dimensional and not limited to specific lanes. Moreover, in pedestrian dynamics, collective dynamics will be formed from individual human nonlinear interactions. Specifically, pedestrian behavior is the result of a series of interdependent decisions which are based on a specific plan. The plan is a latent (unobserved) variable resulting in a series of (observed) actions. However, in state-of-the-art pedestrian flow models, the latent plans and some observed actions are ignored. When it is implemented in simulation software, this leads to an unrealistic representation of individual pedestrian movements and collective crowd dynamics. In order to overcome this issue, a framework for integrated pedestrian behavior modeling based on the concepts of a short-term plan and action, is proposed. This framework integrates the following sub-models: Target Destination Choice Model, Pedestrian Route Choice Model, Pedestrian Pace State Model, and a Pedestrian Movement Model. It captures pedestrians' planning capabilities and interdependent decisions. The parameters of all the components of the framework are estimated jointly by observed pedestrian trajectories using maximum-likelihood theory. Finally, the above behavioral models will be incorporated in the traffic simulator, MovSim (Multi-model open-source vehicular-traffic Simulator developed by Technical University Dresden -TUD) to simulate the normal and evacuation pedestrian environment. This tool will be useful to develop guidelines for local authorities and organizers of mass events in larger cities of Europe and for designing the pedestrian facilities.

Keywords: pedestrian behavior,pedestrian dynamics,self organization,crowd turbulence,simulation
Interconnection between R-loops and co-transcriptional alternative splicing (RLOOP-AS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

R-loops are long RNA/DNA hybrids naturally formed behind RNA polymerase II (Pol II) during transcription, but their persistence is a threat for genome integrity through the creation of DNA damage, leading to cancer development. However, several recent studies reported a new and exciting role for R-loops in gene expression regulation by influencing transcription termination and chromatin modification. As mutations in several RNA processing factors have been shown to stabilize R-loop formation, we propose here to investigate the link between R-loops and co-transcriptional alternative splicing (AS) and to decipher the underlying mechanisms, a hypothesis supported by our preliminary results identifying more than 3000 splice junctions affected by decreased R-loops upon overexpression of RNase H1. The use of a specific antibody to RNA/DNA hybrids and stabilization/removal of R-loops coupled to high-throughput analysis of splicing (RNA-seq), R-loop profiling (DRIP-seq) and Pol II positioning and measurements (PRO-seq) will allow us to investigate genome-wide regulation of AS by R-loop formation. We will use particular AS events as models to elucidate the molecular mechanisms interconnecting R-loops and AS. Moreover, based on our previous expertise, we plan to study the impact of R-loops on DNA damage-induced AS alteration as a model of physiological regulation of AS by R-loops. This project will provide new insights on AS regulation through the formation of R-loops and also on cancer progression through R-loop stabilization. Finally, this project will allow me to acquire independent thinking and scientific leadership to reach an independent academic position in France.

Keywords: r loops,alternative splicing
Light weight airframe structures through combination with high performance materials (LightAir)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Spain
Call: Light weight, certifiable airframe structures through combination with high performance materials (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-11-01
End date: 2020-11-30
Duration (months): 25.0
Total project cost (EUR): 571345.0
EU funding (EUR): 499465.0
Participants: 3
Project status: CLOSED

A further step towards more light weight airframe parts is the combination of existing materials with new high performance materials. This project aims at qualifying new high performance materials for airframe structures following a bulding block approach. To do so, the three first levels of the building block approach will be covered, including coupons, elements and sub-structural details. State-of-the-art test will be introduced in the qualification test campaign that will provide useful material parameters for damage tolerance analysis. The consortium is formed by experienced partners in composite material testing and design. All the coupons and parts will be manufactured by an experienced manufacturer equipped with the latest manufacturing technologies, with the most demanding quality certifications and currently qualified by Airbus and Airbus Helicopters.

Keywords: lightweight,composite materials,high performance,structural materials,qualification,building block
Lifecourse biological pathways underlying social differences in healthy ageing (LIFEPATH)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Ireland,Italy,Australia,Italy,Finland,Switzerland,France,France,Netherlands,United States,United Kingdom,United Kingdom,Portugal
Call: Understanding health, ageing and disease: determinants, risk factors and pathways (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-05-01
End date: 2019-04-30
Duration (months): 48.0
Total project cost (EUR): 7259113.16
EU funding (EUR): 5999756.0
Participants: 17
Project status: CLOSED

The dramatic differentials in healthy ageing, quality of life and life expectancy between individuals of different socioeconomic groups, is a major societal challenge facing Europe. The overarching aim of the LIFEPATH project is to understand the determinants of diverging ageing pathways among individuals belonging to different socio-economic groups. This will be achieved via an original study design that integrates social science approaches with biology (including molecular epidemiology), using existing population cohorts and omics measurements (particularly epigenomics). The specific objectives of the project are: (a) To show that healthy ageing is an achievable goal for society, as it is already experienced by individuals of high socio-economic status (SES); (b) To improve the understanding of the mechanisms through which healthy ageing pathways diverge by SES, by investigating lifecourse biological pathways using omic technologies; (c) To examine the consequences of the current economic recession on health and the biology of ageing (and the consequent increase in social inequalities); (d) To provide updated, relevant and innovative evidence for healthy ageing policies (particularly “health in all policies”) that address social disparities in ageing and the social determinants of health, using both observational studies as well as an experimental approach based on the existing "conditional cash transfer" experiment in New York. To achieve these objectives we will use data from three categories of studies: 1. Europe-wide or national surveys combined with population registry data; 2. Cohorts with intense phenotyping and repeat biological samples (total population >33,000); 3. Large cohorts with biological samples (total population >202,000). The cohorts will provide information on healthy ageing at different stages of life, based on the concepts of life-course epidemiology ("build-up and decline") and multimorbidity.

Keywords: healthy aging,life course,biological pathways,biological embedding,socioeconomic status ses,omics technologies,social inequalities,biomarkers,lifestyle factors
Nutritional epigenetic programming of gut mucosal health in first-feeding fish (Reprogram)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

The growing world population, combined with over-exploited fisheries, indicates that by the year 2030 aquaculture should provide 70% of the fish protein required for human consumption. The potential of early life programming of fish health, by diet-induced changes, could be an important step towards better health management in aquaculture and to promote the need for intensification. The aim of Reprogram is to epigenetically program fish health during the critical early life window to maintain broad immune competence. Evidence suggests that the effect of certain nutrients on the intestinal microbiota can induce epigenetic reprogramming of innate immune cells with long-term positive effects on health. Early epigenetic nutritional programming by butyrate, will be evaluated in first-feeding stages of Nile tilapia, exploring the potential of this dietary additive to enhance gut mucosal health in a fish species important to aquaculture. The project will integrate research methodology relevant to several disciplines including fish immunology, nutrition and microbiology and employ advanced biological approaches such as a germ-free system, to assess dietary effects on the gut microbiome. Reprogram will familiarise the candidate with state-of-the-art genomic approaches, for transcriptome and epigenome by next-generation sequencing nanopore and chromatin immunoprecipitation technology, and with effects on the fish immune system. Hosting, by both a world-class university and at one of the world’s first certified sequencing providers of Oxford Nanopore Technologies (secondment), will increase the potential of the researcher to reach professional maturity during the fellowship. Dissemination of the project results to a wide audience, including a non-profit organisation relevant to worldwide aquaculture, will complement the already excellent career path of the candidate and facilitate her acquisition of a stable research position in Europe.

Keywords: fish nutrition,immunoprophylactics,innate immune response,gut microbiome,gut health,early life stages,disease resistance,epigenetic programming