Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Functional analysis of Alternative Polyadenylation during neuronal differentiation at single cell resolution (SCAPA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Understanding how stem cells differentiate into the myriad of cell types that compose an organism is a fundamental question in biomedical sciences. The recent development of single-cell transcriptomic techniques has already allowed the study of the cell composition of organs and tissues, developmental stages, and even whole adult organisms. Yet, in most cases, these studies are primarily descriptive and often provide little insight into the mechanisms regulating gene expression during cell differentiation. Here, I propose to study the role of alternative polyadenylation (APA) and associated RNA binding proteins (RBPs) in neuronal differentiation. For this purpose, I will: (i) develop new computational tools to detect and quantify APA events from single-cell transcriptomics data; and (ii) perform a single-cell-based functional CRISPR screen. The results obtained from this study will provide an in depth analysis of the changes in gene expression and APA during neuronal differentiation at a single cell resolution and identify dozens of APA targets specifically associated with individual RBPs. Together, this study will provide a solid molecular knowledge of the role of APA in neural differentiation, enabling the development of new personalized medicine therapies, which is in compliance with the Horizon H2020 Health demographic change and wellbeing programme.

Keywords: single cell transcriptomics,crispr screening,alternative polyadenylation,rna binding proteins
Efficient and Stable Blue Quasi-2D Halide Perovskite Light-Emitting Diodes (Blue-PeLEDs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 203852.16
EU funding (EUR): 203852.16
Participants: 1
Project status: CLOSED

Within eight years, metal halide perovskite materials become a new class of semiconducting materials for optoelectronic device application. Their unique and attractive optoelectronic properties, e.g., high crystallinity, low-cost, solution processable with large area deposition, direct band gap nature, low defect density, high color purity (narrow PL emission), tunable optical bandgap, long diffusion length, and balance and high charge carrier mobility. These properties make them attractive and potential candidates for light emitting diodes (LEDs) also. The green and red emissive perovskite-based LEDs efficiency reached ~10%, which is equal to the organic light emitting diodes (OLEDs) at lab scale. But still, blue emissive PeLED efficiency is lower as compared to green and red PeLEDs. The poor stability, poor charge balance, and low photoluminescent are major problems to limit blue PeLED efficinecy. In this proposal, I aims to address these challenges and demonstrate efficient and stable blue PeLED. The research work will be organized according to the following key objectives. 1) Design of blue emissive quasi 2D perovskite material by first-principles calculation (with the support of host organization), b) Deposition of high quality and pinhole-free blue quasi 2D thin film by using various deposition method and their characterization, and c) Fabrication of efficient and stable blue emissive quasi 2D PeLED beyond state of the art, by using device engineering and device physics investigation. This project provides basic scientific knowledge of quasi 2D perovskite materials for blue emissive PeLEDs. The expected results of this project are bandgap engineering of quasi 2D perovskite materials for blue emission with good optoelectronic properties, efficient and stable blue PeLED. Also, I will learn the synthesis of quasi 2D materials from the host organization that will be improved my interdisciplinary knowledge and research skills. The efficient blue PeLED is us

Keywords: light emitting diodes,charge balance,electronics,organic inorganic alloys,nanoparticle
Antimicrobial resistance in engineered wastewater systems – Predicting the impacts of dynamic exposure levels to antimicrobial agents on AMR attenuation and amplification (IDYEA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-04-15
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

Antimicrobial resistance (AMR) spread in the aquatic environment poses a growing public health risk with wastewater treatment (WWT), being the most important but still un-optimised barrier in confronting the global water and nutrient scarcity challenges. Europe’s Water Framework Directive aims to achieve good qualitative and quantitative status of all water bodies. Challenges to the effective separation and recovery of water resources from hazardous materials, notably, antibiotic residues and AMR in WWT were recently identified. In the past, AMR spread was experimentally assessed at static antimicrobial exposure levels that may suffer from lack of environmental representativeness as a result of significant variations in the emission of antimicrobials in urban catchments. IDYEA takes on this challenge by (i) experimental modelling of dynamics in the occurrence and fate of selected antimicrobials; and (ii) developing dynamic simulation models for predicting AMR spread at different time scales in WWT. The inter-sectorial and interdisciplinary IDYEA will be hosted at University of Bath, and supported by the Norwegian Institute for Water Research. It trains one experienced researcher in areas of process modelling, analytical chemistry, molecular microbiology and bioinformatics. IDYEA will offer excellent opportunities for mutual knowledge exchange and technology development. IDYEA’s success is based on achieving the project objectives via seven work packages, including laboratory- and full-scale experimentation, model identification and risk assessment. To provide techno-economic solutions to AMR risk assessment as well as optimised process design and operation, the expected main outcome comprises dynamic process rate and stoichiometric relations for AMR spread. IDYEA will disseminate results via public engagement, reaching out to especially young people, inspiring them to get involved with science to solve real-world problems, thus building our global water futures.

Keywords: antimicrobial resistance dynamics,water quality process modelling,urban water management,wastewater treatment,resource recovery,risk assessment
Anionic redox processes: A transformational approach for advanced energy materials (ARPEMA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-10-01
End date: 2021-03-31
Duration (months): 66.0
Total project cost (EUR): 2249196.25
EU funding (EUR): 2249196.25
Participants: 2
Project status: CLOSED

Redox chemistry provides the fundamental basis for numerous energy-related electrochemical devices, among which Li-ion batteries (LIB) have become the premier energy storage technology for portable electronics and vehicle electrification. Throughout its history, LIB technology has relied on cationic redox reactions as the sole source of energy storage capacity. This is no longer true. In 2013 we demonstrated that Li-driven reversible formation of (O2)n peroxo-groups in new layered oxides led to extraordinary increases in energy storage capacity. This finding, which is receiving worldwide attention, represents a transformational approach for creating advanced energy materials for not only energy storage, but also water splitting applications as both involve peroxo species. However, as is often the case with new discoveries, the fundamental science at work needs to be rationalized and understood. Specifically, what are the mechanisms for ion and electron transport in these Li-driven anionic redox reactions? To address these seminal questions and to widen the spectrum of materials (transition metal and anion) showing anionic redox chemistry, we propose a comprehensive research program that combines experimental and computational methods. The experimental methods include structural and electrochemical analyses (both ex-situ and in-situ), and computational modeling will be based on first-principles DFT for identifying the fundamental processes that enable anionic redox activity. The knowledge gained from these studies, in combination with our expertise in inorganic synthesis, will enable us to design a new generation of Li-ion battery materials that exhibit substantial increases (20 -30%) in energy storage capacity, with additional impacts on the development of Na-ion batteries and the design of water splitting catalysts, with the feasibility to surpass current water splitting efficiencies via novel (O2)n-based electrocatalysts.

Keywords: energy storage,li ion batteries,electrocatalysis
CEREBRAL ASYMMETRY: NEW DIRECTIONS IN CORRELATES AND ETIOLOGY (CANDICE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-03-31
Duration (months): 66.0
Total project cost (EUR): 2497907.0
EU funding (EUR): 2497907.0
Participants: 1
Project status: CLOSED

150 years after Broca's seminal statement "Nous parlons avec l'hémisphère gauche" we still do not know how or why we have this bias. I propose that by studying cases of impaired language development and combining genetic and neuropsychological approaches we will be able to make a leap forward in our understanding of the quintessentially human characteristic of functional cerebral asymmetry. I argue that contradictory findings in the literature may be reconciled if we adopt a novel approach to cerebral asymmetry. In particular, I propose a network efficiency hypothesis which maintains that optimal development depends on organisation of key language functions within the same cerebral hemisphere. In project A, I will combine behavioural measures with functional transcranial Doppler ultrasound (fTCD) measures of blood flow and functional magnetic resonance imaging (fMRI) to identify individual differences in patterns of dissociation between language functions in lateralisation. In project B I will test the prediction that risk for language and literacy impairment is increased if different language functions are represented in opposite hemispheres. For project C, simulations of predictions from genetic models will be tested using data on twin-cotwin similarity in language lateralisation. Project D will test a 'double hit' genetic model that predicts that neurodevelopmental abnormalities, including language deficits and inconsistent asymmetry, arise when there is more than one hit on a functional brain circuit. For this study we will use an existing sample of individuals already known to have one 'hit' on the neuroligin-neurexin circuit, viz people with an additional dose of neuroligin caused by an extra sex chromosome. Project E will focus on individuals with inconsistent patterns of language laterality and will look for rare genetic mutations and structural rearrangements associated with a departure from consistent left hemisphere language.

Keywords: language,cerebral lateralisation,neuroimaging,sex chromosomes
Decentralised technologies for orchestrated cloud-to-edge intelligence (DECENTER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Spain,Slovenia,France,France
Call: Cloud, IoT and AI technologies (H2020-EUK-2018, 2018)
Start date: 2018-07-01
End date: 2021-06-30
Duration (months): 36.0
Total project cost (EUR): 2197700.0
EU funding (EUR): 2197700.0
Participants: 9
Project status: CLOSED

The emerging spring of Artificial Intelligence (AI) will enable innovative applications exploiting the myriad of connected sensors and appliances embedded in every corner of modern life. Currently, AI requires high computational resources only available in high-performance data centers; therefore, realizing an architecture capable of securely processing this unprecedented amount of remotely sensed and potentially sensitive data, as well as conveying timely responses to pervasive configurable actuators is a non-trivial endeavour, requiring the cooperation of multiple parties. To address these challenges, DECENTER aims to realise a robust Fog Computing platform, covering the whole Cloud-to-Things Continuum, that will provide AI application-aware orchestration and provisioning of resources. The project will enrich existing Cloud and IoT solutions with advanced capabilities to abstract features and process data closer to where it is produced. DECENTER will enable a collaborative environment in which multiple stakeholders (Cloud and IoT providers) can securely share and harmoniously manage resources, in dynamically created multi-cloud/edge, federated environments. Cross-border infrastructure federation will be realized via Blockchain-based Smart Contracts defining customized Service Level Agreements, used to commit the execution of verified workloads across multiple, potentially remote, administrative domains. Through such novelties, DECENTER will unlock the potential of innovative decentralised AI algorithms and models, by deploying them across multiple tiers of the infrastructure and federated clouds. The project will follow a lean implementation methodology and validate its concept with real-world pilots executed in urban, industrial and home environments. With its approach, DECENTER will target the emergence of innovative digital businesses, thus providing a competitive advantage to EU and Korean industry and fostering cross-border collaboration.

Keywords: fog computing,blockchain,distributed artificial intelligence,resource federation,cross border applications
Emotional Fit in Intercultural Interactions: Studying mimicry and emotional grounding as micro-processes of (intercultural) belonging. (EMO - FIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2021-03-02
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Migration is often associated with lower well-being among minorities and with lower social cohesion in the host-society. The current project proposes that emotional similarity or fit between minority and majority members may buffer these negative effects, because fit stands for shared attributions of events and shared intentions to act, and has been linked to reduced stress and higher belonging among members of monocultural dyads and groups. However, since there are profound cultural differences in the typical emotional patterns associated with particular situations, there is often emotional misfit in intercultural interactions. My recent studies demonstrated, however, that minorities’ social contact with majority members increases their emotional fit with majority emotional patterns; yet, we don't know which processes account for this increase. The current project consists of two studies that investigate either mimicry or emotional grounding as a potential micro-process underlying emotional fit (objective1). They also assess the effect of emotional fit on the quality of intercultural interactions (objective2). The Research Fellow (RF) proposes a 2-year stay at the University of Amsterdam under the supervision of Prof. Fischer (mimicry-expert), including a 3-month secondment with Prof. Kashima at the University of Melbourne (expert in grounding and micro-processes of culture) to not only obtain theoretical training on mimicry and grounding, but also technical training on how to study these processes. In addition to conducting the studies, the deliverables of this project include two theoretical and two empirical articles, a behavioral coding scheme for grounding, presentations at 6 conferences and the RF’s training of transferable skills like organization, communication and leadership. This project will provide the RF with a unique skill-set, increase her visibility as an independent scholar and, therefore, importantly increase her future career possibilities.

Keywords: emotion,emotional similarity,cultural fit,acculturation,mimicry,grounding,well being
Increased drainage effects on soil properties and water quality (IDESoWa)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Latvia
Call: Widening Fellowships (H2020-WF-01-2018, 2018)
Start date: 2019-07-15
End date: 2024-03-18
Duration (months): 24.0
Total project cost (EUR): 152202.24
EU funding (EUR): 152202.24
Participants: 1
Project status: SIGNED

Soil stores the largest terrestrial pool of organic carbon (C), and can act as a source and/or filter for water pollutants like nitrogen (N), phosphorus (P), and suspended solids (SS). Fine soil particles (clays, Fe, Al and Mn (hydr)oxides, carbonates) play a crucial role in the stability of carbon and nutrients in soil. Previous studies have found that even a few decades of increased drainage, due to subsurface drainage installation, can substantially change the proportion and composition of fine soil particles closest to the drain. This raises questions regarding increased precipitation, and thus increased soil water flux, effects on the mineral composition and C and nutrient stability in soil. By studying soils on a water flux gradient perpendicular to subsurface drainage pipes, the IDESoWa project will calculate soil element fluxes within soil, and their losses with drainage water. It will determine relationships between between drainage water chemistry and soil properties. By jointly analysing published literature, weather records, precipitation chemistry, drain flow quantity, and soil and drainage water properties, the IDESoWa project will develop a conceptual framework for soil development in two common European agricultural soils (Cambisol and Luvisol), and under two agricultural practices (tilled soil vs. pasture).

Keywords: soil minerals,dissolved elements,suspended solids,carbon,nutrients
In-Seat Ventillation and Supply for Personalised Comfort Control on board an Aircraft (COCOON)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Ireland,Poland,United Kingdom
Call: In-Seat Ventilation & Supply for Personalized Comfort Control on Board an Aircraft (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 635050.0
EU funding (EUR): 444534.5
Participants: 3
Project status: CLOSED

The COCOON project will develop and demonstrate integrated seat climatization, ventilation and air supply system, maturing the technology bricks to TRL6 for a standard economy 3-seat row with a target weight of <1kg to achieve personalised comfort control and a 2% fuel saving through reduced thermal load at the cabin level. Thermoelectric heating and cooling modules combined with a ventilation and air supply system will be controlled via a tablet or smartphone to provide advanced in-seat personalised microclimate control. The project will leverage previous work by UTRC which developed an in-seat microclimate control module for the business jet market by adapting it to the economy sector. UTRC Ireland will work with UTAS GEC Poland to design, test and validate a prototype of the system which will be integrated into BE’s current economy 3-row seat configuration and tested at the BE facility in Kilkeel, Northern Ireland.

Keywords: aircraft seating,personal comfort,in seat ventilation,comfort control,environmental control system