Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
First economically-viable process for phosphate recovery (SusPhos)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 4823750.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

The EU has listed phosphorus (P) and phosphate rock as a critical raw material due to supply uncertainties related to 90% imported rock phosphate imports. 90% of used P is irreversibly lost. Our solution converts P rich waste streams, e.g., sewage sludge ashes (SSA) and struvite, into phosphoric acid used in the fertilizer and flame retardant industries and chemicals for wastewater treatment and the construction industry. SusPhos will create Europe's independent supply of P. Flame retardants (FR) and fertilizer industries will readily consume these high-value products. Halogenated FRs are toxic and the manufacturers are switching from halogen-based ingredients to phosphates derived from rock phosphate. There are no methods that can upcycle P-rich SSA for direct use by FR and fertilizer manufacturers that use 3.4M t of phosphates worth €1.84B. By 2026, SusPhos will earn €43.9M p.a. with the potential to displace 20% of conventionally produced phosphates and eliminate 3.9M tonnes of CO2.

Keywords: phosphorus chemistry,phosphate fertilizers,struvite,sewage sludge ash,phosphate flame retardants,phosphorus recycling,circular chemistry,urban mining
Understanding vaccination hesitancy and evaluating single dose and gender-neutral vaccination for improving uptake of HPV vaccines in West and East Africa. (IMPROVE-HPV)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Spain,United Kingdom,Tanzania, United Republic of,Nigeria
Call: Improving modes of delivery, deployment, and uptake of vaccines through phase IV/implementation research (HORIZON-JU-GH-EDCTP3-2023-02-two-stage, 2023)
Start date: 2024-12-01
End date: 2028-05-31
Duration (months): 42.0
Total project cost (EUR): 4130342.5
EU funding (EUR): 3613287.5
Participants: 5
Project status: SIGNED

Cervical cancer, caused by human papillomavirus (HPV), is almost entirely preventable through prophylactic HPV vaccination. Many countries have yet to implement HPV vaccination programmes or are struggling to achieve high vaccine coverage. This presents a major challenge for meeting the World Health Organisation (WHO) cervical cancer elimination target, with 90% of 15 year-old girls being vaccinated against HPV by 2030. Originally licenced as multidose vaccines, WHO has recently recommended that countries can offer a single HPV vaccine dose to 9-20 year olds. The IMPROVE-HPV consortium, a partnership of research institutions in Tanzania, Nigeria, UK and Spain, will investigate barriers to HPV vaccine uptake and the impact and acceptability of new HPV vaccine delivery strategies to improve vaccine coverage and effectiveness and reduce hesitancy. The consortium builds on previous successful collaborations in HPV epidemiology and vaccine research and qualitative research on barriers and facilitators to vaccine uptake. Tanzania has a multidose HPV vaccination programme in girls but will change to a single dose regimen in 2024. A gender-neutral HPV vaccination strategy is currently being implemented in Tanzania as part of a large cluster-randomised trial. Nigeria is one of the first countries to introduce national HPV vaccination with a single dose. Using these opportunities, IMPROVE-HPV will evaluate vaccine effectiveness, uptake and the factors affecting acceptability of (1) HPV two-dose vaccination delivery in females, (2) introducing or changing to a single dose vaccine regimen (3) gender-neutral HPV vaccination, and will also (4) investigate factors influencing vaccine hesitancy, community engagement and perceptions of HPV vaccines. The workplan directly addresses effectiveness and uptake of different HPV vaccine deployment strategies through phase IV/implementation research and will inform policy decision making in sub-Saharan Africa for HPV vaccination programmes.

Keywords: gender neutral single dose hpv uptake effectiveness hesitancy sub saharan africa
Market Entry traceless materials (MaEtra)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Germany
Call: Green Deal innovations for the Economic Recovery (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 3464498.75
EU funding (EUR): 2425149.0
Participants: 1
Project status: CLOSED

traceless materials is a female-founded circular bioeconomy start-up offering a holistically sustainable alternative to conventional (bio)plastics solving global plastic pollution. For the first time, agricultural industry by-products are used to produce storage-stable films, rigid moulds and coatings that provide the beneficial properties of plastics while being compostable in the environment. While bio-based, traceless materials don’t compete with food production, preventing land-use change. Being neither chemically modified nor synthetically polymerized, we expect them not to fall under the EU Plastic Strategy. And in contrast to conventional (bio)plastics, they don’t need harmful additives and have up to 87% lower CO2 emissions. On industrial production scale, they`ll be price competitive to conventional plastics. With this project we’ll build a demonstration plant for first market entry and contract-signing with pilot customers, making the EU part of the solution - not pollution!

Keywords: bioeconomy,circular economy,novel materials,decontamination and de pollution,agricultural products,plastic substitutes
REPURPOSING FUSIDIC ACID AS A SHORT-COURSE ONCHOCERCA VOLVULUS MACROFILARICIDE: A RANDOMIZED CONTROLLED OPEN-LABEL PARALLEL GROUP INTERVENTION PHASE IIA/B PILOT TRIAL (FAME)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: United Kingdom,Cameroon,Germany,Switzerland
Call: Accelerating development and integration of therapeutics against Neglected Tropical Diseases (NTDs) in sub-Saharan Africa (HORIZON-JU-GH-EDCTP3-2024-01-two-stage, 2024)
Start date: 2025-09-01
End date: 2029-02-28
Duration (months): 42.0
Total project cost (EUR): 5121718.75
EU funding (EUR): 5121718.75
Participants: 4
Project status: SIGNED

Onchocerciasis (river blindness) is a vector-borne, filarial nematode neglected tropical disease (NTD), affecting an estimated 21 million individuals, 99% of which reside within 31 Sub-Saharan African countries. Approximately 14.6 million onchocerciasis infected individuals suffer skin disease and 1.15 million are visually impaired. Onchocerciasis is prioritized for elimination as a public health problem by The World Health Organisation with ambitious targets set as part of the NTDs Roadmap to 2030. To enable elimination targets from 2030 onwards, WHO and major stakeholders, including funders and product development partners, recognize that a new short-course curative (macrofilaricide) treatment is required (or a short-course agent which permanently blocks parasite reproduction and transmission), as well as a safe alternative strategy to eliminate onchocerciasis where the related filaria, Loa loa is co-endemic in Central Africa. We have pre-clinical data from efficacy screens and pharmacokinetic-pharmacodynamic modelling that positions the registered antibiotic, fusidic acid (FA) at the late laboratory validation stage as a potential seven day macrofilaricide drug cure, via targeting the Onchocerca filarial symbiont, Wolbachia. We propose to advance FA into clinical testing. We will undertake dose ranging to assess FA systemic exposures and safety in a Cameroonian onchocerciasis target population aligned with acceptable delivery (once, or twice daily dosing, maximum 14 days). We will establish exploratory efficacy proof-of-concept utilising early endpoint indicators of Wolbachia depletions within female O. volvulus and impact on embryogenesis compared against a 4-week doxycycline gold-standard treatment comparator, six months post-treatment. The major output of FAME will be to develop a development plan of clinical safety, pharmacology, pilot efficacy and market access scoping for entry into phase II trials on a pathway toward registering a new onchocerciasis cure.

Keywords: onchocerciasis,river blindness,wolbachia,macrofilaricide,elimination
SMART-AML: Shaping Marrow Adiposity to Redefine Treatment in Acute Myeloid Leukemia (SMART-AML)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

Acute Myeloid Leukemia (AML) is an aggressive hematologic malignancy characterized by the uncontrolled proliferation of myeloid cells, which hijack the bone marrow (BM) and compromise its physiological functions. AML prognosis remains poor, with <10% of patients above 60 years old surviving after 5-years. Recent discoveries have revealed the key role of BM microenvironment in harboring and protecting leukemic stem cells from chemotherapy, contributing to AML relapse. Therefore, targeting the hijacked BM niche and transforming it into a “tumor-inhospitable” microenvironment represents a promising therapeutic strategy. In adults, bone marrow adipose tissue (BMAT) is the predominant component of the BM microenvironment, making it an appealing target. However, the role of BMAT in AML development, drug resistance and survival is still controversial. With SMART-AML, I aim at identifying AML cells-related changes within the BMAT/BM microenvironment, to introduce BMAT manipulation as therapeutic strategy to sensitize leukemic cells to chemotherapy. To achieve this goal, I will exploit state-of-the-art bioprinting technologies to engineer a perfusable, humanized bone/BMAT 3D biomimetic microenvironment. Patient-derived AML cells will be cultured within the engineered platform to characterize the AML-induced BMAT changes in a controlled environment, with limited variables. Finally, BMAT will be manipulated (i.e. expanded or reduced), to determine the potential of this therapeutic approach on enhancing the efficacy of chemotherapy on leukemic stem cells and reducing the chance of relapse. This project will prepare me to become a tenured scholar, strengthening my academic profile and enabling me to establish myself as an independent principal investigator with a research line on advanced bone disease modeling. It will also create opportunities to perform cutting-edge research at the intersection between tissue engineering and cancer research.

Keywords: bioprinting,biomimetic microenvironment,acute myeloid leukemia,bone marrow adipose tissue,bioreactor
A COMPREHENSIVE TRUSTWORTHY FRAMEWORK FOR CONNECTED MACHINE LEARNING AND SECURE INTERCONNECTED AI SOLUTIONS (CoEvolution)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Research and Innovation actions
Countries involved: Greece,Italy,Germany,Spain,Ireland,Cyprus,Switzerland,Austria
Call: Security of robust AI systems (HORIZON-CL3-2023-CS-01, 2023)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 5999688.75
EU funding (EUR): 5999688.75
Participants: 17
Project status: SIGNED

The contemporary AI landscape demands a holistic framework ensuring security across the supply chain and entire AI lifecycle. Despite existing adversarial attack techniques, a comprehensive end-to-end flow for identifying threats and vulnerabilities with associated risks is lacking. The EU, through initiatives like the AI Act, emphasizes safety and trustworthiness in AI applications but lacks a system managing weaknesses in a networked AI-supply chain. The CoEvolution project integrates its architecture components to create an end-to-end Security, Trust, and Robustness (STR) assessment solution, generating context-aware AI models characterized by their AI Model Bill of Materials (AIMBOM). The goal is a universal hub providing a coherent STR risk assessment and security assurance flow, aligning with MLDevOps and EU AI regulatory frameworks. The paradigm includes novel AI model descriptions, AIMBOM management, security monitoring, and context awareness. CoEvolution introduces a new STR paradigm based on Bills-of-Materials, offering a unified approach to describing AI models in supply chains, ensuring STR compliance with EU directives on trust, fairness, data governance, and GDPR guidelines. Open source trusted datasets and CoEvolution-developed AI models enhance the hub's capabilities, aiming for a robust, adaptable risk analysis and security assessment framework aligned with evolving AI cybersecurity threats.

Keywords: ai model bill of materials,security,trust,and robustness,context aware ai models,adversarial attacks
Bioorthogonal Implantable Iontronic Switch to Temporally Control the Local Release of Chemotherapeutics (bioSWITCH)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden,Netherlands,Austria,Hungary
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-03-01
End date: 2026-02-28
Duration (months): 36.0
Total project cost (EUR): 4420511.0
EU funding (EUR): 4420511.0
Participants: 7
Project status: SIGNED

Our vision for a new type of cancer treatment is based on an implantable therapeutic system capable of ‘programmable’ on-demand delivery of drugs directly to the tumor. We conceive an implantable iontronic switch (bioSWITCH) to enable a spatiotemporally controlled administration of highly potent chemotherapeutics, without the need for systemic administration of (pro)drugs or drug conjugates. This radically new technology will be realized by a combination of next-level tools. As a result, bioSWITCH can generate previously unobtainable discrete as well as continuous drug concentration profiles at the tumor site, and thus allows for the use of highly potent drugs that are otherwise not applicable due to high cytotoxicity. The goal is to demonstrate the technology’s potential to effectively interfere with tumor progression using a xenograft pancreas cancer mouse model. Efficiently shrinking tumors in size allows for surgical resection of previously non-operable tumors and dramatically increases survival rates. Our consortium of world leading academics and pioneering SMEs will ensure the translation of this disruptive technology into the market to maximize the socioeconomic impact.

Keywords: bioelectronics,drug delivery,pancreatic cancer,bioorthogonal tools,implanted devices,iontronics
SURFACE WATER INFORMATION MANAGEMENT (SWIM) (SWIM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: EU Space
Destination: EU Space
Action type: Research and Innovation actions
Countries involved: Cyprus,United States,Spain,Colombia,Germany
Call: Designing space-based downstream applications with international partners (HORIZON-EUSPA-2023-SPACE, 2023)
Start date: 2024-11-01
End date: 2026-04-30
Duration (months): 18.0
Total project cost (EUR): 1368141.09
EU funding (EUR): 999778.59
Participants: 6
Project status: SIGNED

The SWIM (Surface Water Information Management) project assembles a geographically diverse and interdisciplinary consortium, comprising of SMEs, a research organisation, and an end-user NGO from 3 European countries (Cyprus, Germany, and Spain) and two international Copernicus cooperation partners (USA and Colombia). Together, we aim to develop and test at TRL4, a Copernicus-based surface water information management application that provides continuous, reliable, and accurate monitoring and reporting of various ecological parameters (water quality, algal blooms), predict future conditions (water quantity and water balance), assess risks related to surface waters (floods and droughts), and translate this information into direct, easy-to-understand, actionable recommendations via an artificial intelligence decision support system and an interactive, user-friendly layout (alerts, data visualization layers, and reports) to be used by water management authorities and relevant stakeholders for surface water management and more reliable decision-making. SWIM will contribute to UN’s Sustainable Development Goal 6- ‘Ensure access to water and sanitation for all’ and other important European initiatives and directives like the Water Framework Directive and Surface Waters Ordinance. SWIM will use surface water information from Copernicus Earth Observations (EO) satellite data that is calibrated and enhanced using in-situ measurements from our patented satellite based IoT (Internet of Things) hardware platform called WAMO (Water Monitoring) developed by the consortium. The platform will combine three main aspects of water management for specific water basins: a water quality module including identification, tracking, predictive analysis and reporting of water quality indicators; a water balance module for assessing the hydrological balance of water bodies and lastly a natural disaster assessment module for identifying and mapping of areas at risk of floods and droughts.

Keywords: water assessment,water quality,flood and drought risk assessment,downstream application,copernicus,egnss,early warnings,in situ data,eo data,copernicus data
Understanding biodiversity-ecosystem function and biodiversity-stability relationships across spatial and organizational scales (GorBEEa)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1998793.0
EU funding (EUR): 1998793.0
Participants: 1
Project status: SIGNED

The role of biodiversity in shaping ecosystem functioning (EF) and stability (ES) is a fundamental question in ecology. The mechanisms underlying biodiversity-EF (BEF) and biodiversity-ES (BES) relations have been extensively studied, but they have been approached separately, and we thus lack an understanding of how EF and ES relate, a particularly urgent task in the face of global environmental change. Further, most research has been conducted within single trophic communities and relatively small spatial scales, and whether the types of relations observed are scalable and applicable to multi-trophic communities is unknown. To address these shortcomings, in GorBEEa I propose to merge BEF and BES research (i) within multi-trophic communities, in this case plant-pollinator interaction networks, (ii) across spatial and organizational scales (from local to regional scales, and from populations, to communities), (iii) taking a dynamic perspective that considers multiple temporal scales (within day, within season, between years), and (iv) following a multi-functional approach, analysing several functions on the resource side, but also considering the many times neglected impact on the consumer side. Further, (v) to understand aspects of stability beyond temporal invariability, I will introduce a perturbation to the system, to understand whether biodiversity in multi-trophic communities provides higher resistance and resilience values. GorBEEa represents an ambitious research programme at the intersect of population, community, ecosystem, and conservation ecology, that will deliver an understanding of how declining biodiversity levels influence natural ecosystem dynamics. But it will also offer an applied angle, through collaborations with stakeholders to develop scientifically-informed management practices.

Keywords: ecosystem function,ecosystem stability,perturbation,plant pollinator interactions,interaction networks,spatial dynamics,temporal dynamics,managed honeybee impacts