Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Physics-informed nEuRal networks for SEVERe wEather event prediction (PERSEVERE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: CLOSED

The novel development of Physics-Informed Neural Networks (PINNs), which incorporate the constraints given by physics laws into the training process, as excellent means of computing fluidic fields and their characteristics such as velocity and pressure has open the gates to numerous applications. One of them is the data enhancement of experiments, since PINNs can reconstruct by means of applying the Navier-Stokes equations as loss function the full fluid domain in areas where experiments are limited by technology. On the other hand, the development of Generative Adversarial Networks (GANs) as robust networks with excellent precision but excessive computational costs leaves the door open to further investigate new applications where PINNs and GANs can be combined to amplify their strengths and reduce their weak points. One of those applications regards the forecast of severe weather conditions, where PINNs are useful to compute the fluidic behavior of storms approaching a certain location, whereas GANs can incorporate many additional parameters, such as wind speed, humidity, temperature and electric content, which may be essential to determine if in the following 48h a certain location is going to suffer from severe weather conditions. The estimation and forecast of storms is essential to the air transport industry, since the losses incurred due to delays and deviations of air traffic caused by the presence of storms have been reported to be over $38.5 billion in USA. The development of a computational architecture which is able to determine if severe weather events are going to take place within the next 48h is therefore of crucial importance. There exists no model nor application in which the combined strengths of PINNs and GANs have been put into practice, one to rapidly estimate the fluidic behaviour of a moving storm, the second to calculate the properties of the field with high precision.

Keywords: aerodynamics,air transport,severe weather forecast,meteorology,neural networks
THREATS to biodiversity conservation: Global impacts of renewable energies and the interaction with other human activities (THREATS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-12-31
Duration (months): 28.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

Renewable energy developments are essential to fighting climate change but we do not yet fully understand their global spatial patterns and impacts on biodiversity conservation. Moreover, they could interact with other human pressures that are already threatening wildlife species. Understanding these interactions, the underlying factor triggering these threats, and their effects on protected areas, especially in areas where more threats overlap, would help us better prioritize and optimize efforts to break free from fossil fuels while also halting the loss of biodiversity. Therefore, this project aims to improve our current knowledge of the threats that renewable energy developments represent to biodiversity and to explore and advance our understanding of the interactions with other human-induced threats to biodiversity. This project will map for the first time, the likelihood of impact of all renewable energy developments using the International Union for Conservation of Nature Red List of threatened species for amphibians, birds, and mammals. Together with other threat maps (agriculture, afforestation, overhunting, invasive species, pollution, and climate change), obtained from peer-reviewed public sources, this project will identify and assess the interactions between threats through a co-occurrence matrix, and identify areas where more threats overlap. Finally, it will evaluate the socio-economic factors that are triggering all these threats and their effects on protected areas in two contrasting regions, Europe and South America. This project will promote a link between conservation and energy developments, providing relevant information to nature policies, which is both timely and urgent, as human impacts have become catastrophic on biodiversity. It will also have a substantial impact on my career, as new skills in ecological modelling and global threat assessment will complement my previous experience in human-induced threats and conservation biology.

Keywords: human induced threats,birds,mammals,amphibians,landscape ecology,iucn red list,threats interaction
Conformal Organic Devices for Electronic Brain-gut REAdout and CharactERisation (CODEBREAKER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: United Kingdom
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2498444.0
EU funding (EUR): 2498444.0
Participants: 1
Project status: SIGNED

Over 100M people in Europe live with a digestive disorder, and this number is rising. The gastrointestinal (GI) tract is a complex ecosystem which facilitates digestion and regulates food intake in addition to regulating immune function in order to effectively guard against pathogens while tolerating innocuous antigens. It also acts as a sensory organ. The GI tract is connected with the brain via neuronal and hormonal signalling pathways which form the gut-brain axis (GBA). Dysregulation of the GBA contributes to local pathologies such as inflammatory bowel disease and is implicated in the development of neuropathologies such as Parkinson’s and multiple sclerosis. Technologies for diagnosis of gastrointestinal (GI) dysfunction are underdeveloped and have not found widespread clinical utility. GI tract complexity has made it difficult to measure GI function and collect spatio-temporal information that could improve diagnosis or treatment. CODEBREAKER will generate a suite of conformal conducting polymer devices which interface with the GI tract, elucidating pathways of the GBA in health and disease. To do this we will develop new methods to measure key functions of gut: 1. Gut permeability (barrier integrity), 2. gut motility, and 3. enteric nervous system function. Recent, key technology advances in my group set the groundwork to enable CODEBREAKER. Our devices offer unparalleled functionality monitoring that can be applied on a variety of models and tissues of varying complexity. Where possible, devices will be tested on advanced tissue engineered models in vitro and perfused ex vivo tissues (e.g. rodent and pig). Where functionality is lost ex vivo or in vitro, in vivo experiments will be used. We will also investigate the use of permeability as an in vivo diagnostic compatible with endoscopy. CODEBREAKER has the potential to yield huge dividends in our understanding of how gut function and diet can affect our health, not just in the gut but also the brain.

Keywords: gastrointestinal tract,organic bioelectronics,gut brain axis,enteric nervous system,mucosa
The P2X7 receptor as treatment target for traumatic brain injury-induced epilepsy (EpiPrevent)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 215534.4
EU funding (EUR): 215534.4
Participants: 2
Project status: SIGNED

Post-traumatic epilepsy (PTE) is one of the most common, devastating complications following traumatic brain injury (TBI), and is particularly prone to drug-refractoriness. Critically, current anti-seizure medication remains ineffective in over 30% of patients, with no impact on disease progression and frequent adverse side effects. Increasing evidence suggests inflammation as one of the main contributors to the development of PTE. ATP, released during pathological processes in the brain, functions as an important extracellular signalling molecule driving inflammatory processes via the activation of the ATP-gated ionotropic P2X7 receptor (P2X7R). Increasing evidence suggests that targeting of the P2X7R provides potent anticonvulsive effects and, possibly, disease-modification during epilepsy. Whether P2X7R antagonism prevents the development of PTE has not been investigated to date. My planned research will 1) investigate the disease-modifying potential of targeting the ATP-gated P2X7R on TBI-induced epilepsy and associated comorbidities, thereby sparing patients from life-long drug dependency, and 2) evaluate the potential of P2X7R-based PET imaging as novel patient stratification tools to identify patients at risk of developing PTE for an earlier and more effective treatment start. EpiPrevent brings together a team of experts in purinergic signalling, industrial partners developing novel P2X7R antagonists and clinicians specialised in epilepsy. This highly interdisciplinary and intersectoral approach will add a significant contribution to the understanding of purinergic signalling during TBI, providing novel diagnostic and therapeutic approaches. The skills acquired during the research project, the excellent training record of the supervisor and host institution and the outstanding resources for learning and development available at RCSI will give me the tools necessary to establish myself as independent scientist.

Keywords: traumatic brain injury,epilepsy,atp,p2x7 receptor,positron emission tomography
IVERdrought: Investigating how Intra-individual Variability in Embolism Resistance helps plants to cope with increasing drought (IVERdrought)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Drought-induced plant mortality is increasing across the world and inter-individual variation (IIV) in embolism resistance (a key driver of plant death) is a likely important, but unknown, factor in the ability of plant species to tolerate and adapt to drought. Recent research has shown that embolisms (air-bubbles that form in the plant water transport system under drought-stress) cause tissue death, highlighting the critical importance of quantifying embolism resistance for understanding drought damage and death. Recently developed, non-invasive techniques to visualise embolism (such as the OVT, the use of optical cameras and light) enable us to quantify how embolism resistance varies within, between and among individuals. Emerging research using the OVT suggests that IIV in embolism resistance is high in the canopies of drought-resistant trees. Utilising both natural and experimental systems, IVERdrought will investigate the role of IIV in leaf embolism resistance at the species-scale for the first time, and determine how coordination or trade-off’s with other traits may confer species drought resistance. This project will combine physiology, ecology, statistics and more, involve a global network of researchers, a highly skilled supervisor and host institution, and activities to engage scientists and the local and global community. The applicant, Dr Kate Johnson, has the ideal technical and communication skills to undertake this project, which is also perfectly designed to expand her skillset, leveraging her career. By interpreting key aspects of plant physiology through the lens of ecology, IVERdrought will bridge the gap between these fields, providing a novel and urgently needed assessment of what drives species drought resistance in an increasingly arid world.

Keywords: xylem,plants,ecology,physiology,drought,stress,embolism,variation,resistance,tolerance,plasticity,adaption,acclimation
Why late earliest occupation of Western Europe ? (LATEUROPE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2558250.0
EU funding (EUR): 2558250.0
Participants: 1
Project status: SIGNED

The project aims to question human migrations and peopling: why the earliest hominins did occupy Western Europe later than other portions of Eurasia? Early Hominins, conquered Eurasia, long before Modern Humans, the single Homo species living now on the earth. They conquered Eurasia along a rapid “Out of Africa” movement but left Europe empty during almost 1 million years. Western Europe did indeed face environmental constraints. This subcontinent is in a remote corner of Eurasia but other large Eurasian peninsulas are dead-ends as well. Certainly, Western Europe mixture of various environments and topographies did change a lot over time and the succession of climates, then causing favorable territories for human occupations to fluctuate. However, archaeology in Asia and the Levant shows that hominins did overcome variable climatic conditions and geographies. Investigating why Western Europe have remained out of the “Oekoumen” for so long is our research proposal LATEUROPE, that we base over datasets of interdisciplinary and behavioral materials enriched by future fieldworks in several specific sites and biomes on the key period before 500 ka. This will question at the local, regional and continental scale, the environmental, geographic and climatic conditions of Europe as compared to the rest of Eurasia and the characteristics of the hominin occupations and behaviours, or/and if a minimum degree of cognition was required to thrive in these lands. Databases will input multiple scenarios combining migration patterns and internal evolution mechanisms, using conceptual modeling and spatial agent-based simulations. This formalized combination of modeling and field methodologies is an epistemological advance for bringing interdisciplinarity to reality, allowing us to deeply question the ability of Homo species to adapt themselves to harsh environments, to face environmental shocks and changes on a long term scale.
Translational Research and Training on Atrial Cardiomyopathy as a Key to Better Atrial Fibrillation Management (TrackAF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Austria,Netherlands,Spain,Italy,United Kingdom,Belgium
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-03-01
End date: 2030-02-28
Duration (months): 48.0
Total project cost (EUR): 4624894.23
EU funding (EUR): 4374295.2
Participants: 17
Project status: SIGNED

Atrial fibrillation (AF) is a complex cardiac arrhythmia with multifactorial causes and poses significant global healthcare challenges due to increased morbidity, mortality, and healthcare costs. The TrackAF project will train 15 researchers to address gaps in our understanding of AF, atrial cardiomyopathy (ACM) their management and consequences by integrating advanced data-driven and mechanistic computational modelling, clinical AI and wet-lab research with a focus on extended time scales of AF aetiology and progression. Systematic identification of their longitudinal effects of age and sex on AF progression and treatment outcomes remains challenging. The 2024 European AF guidelines highlight evidence gaps, including the variability in AF and ACM evolution and the need for personalised risk prediction. TrackAF will bridge these gaps through a comprehensive, interdisciplinary and intersectoral research and training program to develop innovative approaches to AF prevention, diagnosis and treatment, supporting key health policies and contributing to the UN's Sustainable Development Goals. Our objectives include enhancing AF prediction and risk stratification using novel biomarkers, refining diagnostic techniques by multimodal stratification and improving acute and long-term management and treatment outcomes through integration of mechanistic and data-driven decision-support models. TrackAF's doctoral training will produce medical scientists with expertise in AF through a balanced structure of core research, formal training and practical secondments. This interdisciplinary approach gives doctoral candidates the ideal preparation for diverse career paths in medical science by integrating technical, ethical and legal aspects of medical research to foster innovation and collaboration across academia, industry and healthcare. The TrackAF outcomes will contribute to reducing the burden of AF and thereby improve patient quality of life across Europe and beyond.

Keywords: atrial fibrillation,atrial cardiomyopathy,in silico medicine,in silico trials,virtual cohorts,clinical data science,electrocardiography,digital twin
Metabolomics-driven Molecular Source Analysis for personalized medicine in children (MeMoSA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1999763.0
EU funding (EUR): 1999763.0
Participants: 1
Project status: SIGNED

While recent advent empowered the new reality of holistic metabolic phenotyping, we are currently still unable to accurately determine the source(s) of the underlying metabolites. This is undoubtedly the main stumbling block in inferring causality to new biomarkers for disease prevention, prediction, and prognosis, particularly given the rapidly increasing burden of metabolic diseases. At the same time, conventional metabolomics methods do not meet the requirements for adoption in clinical practice. MeMoSA will address these issues by unraveling the source hierarchy of the gastrointestinal metabolome, ultimately enabling effective personalized treatments through longitudinal source modulation and follow-up. First, two workflows for 1. high-throughput comprehensive 2D metabolomics and lipidomics and, 2. rapid clinically applicable ambient ionization metabotyping, will be developed. Second, molecular fingerprints of our unique deeply phenotyped pediatric cohorts (1.5k children) will be generated and advanced machine learning algorithms will be used to predict metabolite abundances based on their sources, i.e., diet, lifestyle, anthropometrics, microbiome, drug intake, psychological factors, clinical markers, etc. Third, a combination of in vitro digestions, in vivo humanized mice, and in silico experiments with selected source variables will be designed to contribute to our understanding of source-metabolite causality. These mechanistic insights will be used to build dedicated intervention trials in children with specific source-dominated metabotypes. MeMoSA will lay the foundation for integrating metabolomics into personalized and preventive medicine in children through (i) better prediction of individual metabotypes in relation to health; (ii) in-depth insight into metabolite sources, which will foster a framework for biomarker qualification and unraveling disease etiology; (iii) greater treatment efficacy through dedicated metabolome-driven source modulation.

Keywords: metabotyping,mass spectrometry,pediatrics,4p medicine