Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advanced Photonic Integrated Circuits Pilot Line for Europe (PIXEurope)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Research and Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: Spain,Ireland,Netherlands,Finland,Belgium,Portugal,Poland,Austria,Italy,France,United Kingdom
Call: Call for proposals for Set-up, integration and process development (HORIZON-Chips-2024-RIA-CPL-5, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 176054649.6
EU funding (EUR): 88027324.81
Participants: 21
Project status: SIGNED

PIXEurope will establish a globally unique Open Access Pilot Line, addressing key technological and production challenges associated with Photonic Integrated Circuits (PICs). PIXEurope is a distributed Pilot Line, built on a collaboration between world-class research organisations using state-of-the-art equipment to develop breakthrough technologies and processes across the complete PIC supply chain. This includes improved monolithic chip fabrication and novel materials integration processes, advanced wafer-level packaging processes, and high-throughput test and reliability analysis procedures. These breakthroughs will also enable the integration of PICs with EICs to produce advanced semiconductor systems. PIXEurope’s concept is to create a uniquely unified research, training and commercialisation platform, providing well-coordinated services to develop and de-risk advanced PIC technologies, giving Europe unprecedented control, sovereignty and a competitive advantage in this critical technology. PIXEurope will work with European manufacturers to transfer breakthrough technologies and processes to industry, creating a unique research and industrial ecosystem to increase PIC production capacity. PIXEurope will also support research organisations to bridge the gap between lab and fab, accelerating research commercialisation, and will train a high-skills workforce, ensuring companies can access the expertise they need to grow their businesses. When operating, PIXEurope will offer an unparalleled range of MPW runs, from chip to package and test, as well as specialised services. PIXEurope will establish in-depth online and hands-on training courses on advanced PIC manufacturing, targeting 1000 attendees annually. PIXEurope will foster a vibrant European PIC community, accelerating research commercialisation, increasing the production capacity and strengthening supply chains, enabling European industry and researchers exploit the vast potential of PIC technologies.

Keywords: photonic integrated circuits pics,photonic pilot line,open access pilot line,photonics technology scale up,chips,hybrid integration,packaging,test,design kits,technology sovereignty
Exploiting Laser-driven Plasma Chemistry for Ultra-high Repetition Rate Nonlinear Optics (EXPLORE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 2201881.0
EU funding (EUR): 2201881.0
Participants: 1
Project status: SIGNED

Nonlinear optical methods play a crucial role in science and technology and enables scientists across the globe to manipulate light at will and access the entire electromagnetic spectrum, from X-rays to Terahertz (THz) waves via frequency conversion. Accessing material nonlinearities requires high input light intensity, thus novel laser sources are instrumental in advancing nonlinear optics (NLO). The first revolution in NLO was enabled by wide access to femtosecond (fs-) laser sources, that ensured sufficiently high peak powers from table-top systems to access most material nonlinearities. However, these high-peak powers are usually generated at low repetition rates below 1kHz, due to laser source limitations in average power. In this case, the material nonlinearity recovers by the time the next pulse in the train arrives and every pulse sees the “same” material. EXPLORE proposes that the second revolution will be the use of high-repetition rate pulses to collectively tailor the nonlinear properties of the medium and allow for the same interactions at greatly reduced energy, thus opening the door to highly NLO at very high repetition rates without prohibitively increasing complexity, with wide implications across disciplines making use of secondary sources of radiation and nonlinear optical methods. EXPLORE aims to demonstrate this breakthrough idea by using advanced high-power and high-repetition rate laser technology to significantly enhance the nonlinear response of atmospheric plasmas by driving it at ultra-high repetition rates >10 MHz. In these conditions the air plasma chemical composition does not recover from pulse to pulse and a rich chemical mixture can be tailored to enhance the nonlinear properties such that much lower peak power is required for the nonlinear interaction. To prove our theory, we will apply the concept to demonstrate a high repetition rate watt-level air-plasma based Terahertz time-domain spectrometer with unprecedented performance.

Keywords: terahertz science and technology,secondary sources
Symbol Elimination in Reliable System Engineering (SYMELS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Austria
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-06-01
End date: 2020-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

We are living in a world that is increasingly run by software. Daily activities, such as online banking, mobile communications and air traffic use, are controlled by software. This software is growing in size and functionality, but its reliability is hardly improving. We are getting used to the fact that that computer systems are error-prone and insecure. To (re)gain the trust of end-users in software and Web services, formal automated reasoning is one of the main investments made by ICT companies in preventing software errors. To improve in this area, one should answer some important questions, such as - Which methods in automated reasoning are the most appropriate for proving software error-free? - What needs to be done to apply research in automated reasoning to large-scale code bases? Our SYMELS project aims at answering these questions by bringing our symbol elimination method to the ICT market. The key innovation brought in by SYMELS is the ability to automatically generate and prove first-order properties of software that prevent programmers from introducing errors while making changes in this software. Our initial results show that symbol elimination can be a breakthrough method: e.g. when testing programs manipulating computer memory it was able to prove that over 80% of test cases are guaranteed to have the expected behavior. Most of these test problems were coming from industry, where similar proofs required very costly human work. Analyzing such programs requires reasoning about program properties in full first-order logic. No other method can reason about such properties with the same accuracy and expressiveness as SYMELS. For the proof-of-concept, SYMELS gives ICT customers and investors a tool-supported methodology for ensuring continuous growth in software functionality, thus increasing software reliability and user's trust in software technologies.

Keywords: software verification,system engineering,formal methods,automated reasoning
ENgagement and JOurnalism Innovation for Outstanding Open Science Communication (ENJOI)

Framework: Horizon 2020 — Science with and for Society
Programme: Improving knowledge on science communication in order to improve the quality and effectiveness of interactions between scientists, general media and the public
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Belgium,Netherlands,Portugal
Call: Taking stock and re-examining the role of science communication (H2020-SwafS-2020-1, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 1222462.5
EU funding (EUR): 1222462.5
Participants: 6
Project status: SIGNED

There are no recognized standards in science journalism and communication, nor principles or indicators of quality. And yet they are needed, particularly in a moment when science communication is more than ever a key factor in facilitating democratic deliberation and in fighting misinformation. To fully benefit from a digital society, citizens need to feel that the information they receive responds to their needs and is useful to face and solve their problems. The climate crisis, the recent pandemic and many more global challenges can only be dealt within a framework of policies and actions properly informed by science, allowing all relevant stakeholders to decide and act on the basis of evidences and not of noises and misinformation. ENJOI will explore and test engagement as a key asset of innovation in science communication distributed via media platforms, with a strong focus on journalism. Through a combination of methodologies and in collaboration with producers, target users and stakeholders of science communication, ENJOI will co-create and select a set of standards, principles and indicators (SPIs) condensed to a Manifesto for an Outstanding Open Science Communication. ENJOI will deploy a series of actions via Engagement Workshops, Labs, field and participatory research, evaluation and testing phases.It will also build an Observatory as its landmark product to make all results and outputs available to foster capacity building and collaboration of all actors in the field. ENJOI will work in four countries: Belgium, Italy, Portugal and Spain, taking into account different cultural contexts. ENJOI’s ultimate goal is that of improving science communication by making it more consistently reliable, truthful, open and engaging. Contextually, ENJOI will contribute to the active development of critical thinking, digital awareness and media literacy of all actors involved in the process.
Development of a Sensor with WIde Spectrum Sensitivity for MOnitoring of Damage and Defects In Composite Structures (SWISSMODICS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Switzerland,France,France
Call: Innovative miniaturized sensing device for large wave length spectrum reception capability as a tool for quality control and aircraft maintenance (H2020-CS2-CFP10-2019-01, 2019)
Start date: 2020-07-01
End date: 2023-11-30
Duration (months): 41.0
Total project cost (EUR): 923172.0
EU funding (EUR): 923172.0
Participants: 4
Project status: SIGNED

Shocks on a composite structure of an aircraft can propagate and generate delamination at a distant place. There is currently no other method than regular inspection of the structure to detect these delamination, which requires to immobilize the aircraft. The SWISSMODICS project ambitions to answer the lack of efficient diagnostic tools by providing a miniature, ultra-thin camera to be incorporated in the composite structure of an aircraft where delamination risk to occur. This will considerably facilitate diagnostic and reduce immobilization time, even allowing in-operation diagnostic. The SWISSMODICS project will develop a camera sensitive to X-ray, visible and infrared light. This will be achieved by creating a monolithic detector made of a CMOS pixel array with configurable pixels to the specificity of each wavelength range, covalently bonded to an absorber with areas sensitive to these 3 different wavelength ranges. The detector will be tested on a panel of section of fuselage in composite, with delamination defects representative of real defects. The work will be executed by a consortium of 3 companies with complementary competences. CSEM, in Switzerland will develop the CMOS integrated circuit. G-ray, also in Switzerland, will develop the absorber with areas sensitive to different wavelength ranges and will perform wafer to wafer covalent bonding between the CMOS wafer and the absorber wafer. Finally, Almay, a French engineering company with experience in composites for the aeronautical applications, will provide guidance and will integrate and validate the detector on composite structures with defects. This new sensor will be a breakthrough in non-destructive testing and will open the door to "intelligent" composite structures. In aeronautics, it will not only reduce immobilization time but also enable to reduce the security margin on composite parts thanks to continuous monitoring, resulting in economy of weight and fuel.

Keywords: x ray,visible,infrared,miniature camera,embedded sensor,non destructive testing
A comprehensive analysis of microRNA-124 regulated gene networks and its role in epilepsy. (EpiMIRgen)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2018-06-30
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

Evidence is emerging that rapid, profound and persisting changes in gene expression regulation and post-transcriptional regulation underlies the epileptogenic process. The current proposal builds on preliminary data which demonstrates that rapid reduction of a microRNA; miR-124, causes increased expression and activity of NRSF, a master-regulator of epileptogenesis. The current proposal will build on this and investigate other gene networks regulated by miR-124 in neurons, by developing the first miR-124 KO mouse using CRISPR technology and a miR-124 overexpressing mouse. These transgenic mice will then be profiled at the epigenomic level using ATAC-Seq, the transcriptome level using HITS-CLIP and ribosomal profiling and the proteomic level using mass spec. This will be the first study to examine the pleiotropic role of miR-124 in mature neurons and identify gene networks regulated by this neuronally enriched miRNA. If miR-124 disruption causes aberrant activity of epigenetic modifiers including NRSF then we will test whether miR-124 restitution can restore correct gene expression networks and prevent or modify epileptogenesis in a mouse model of the disorder. Next we will determine whether data obtained in mouse models is translatable to the human form of the condition by obtaining and maintaining resected human epileptic hippocampus live in culture. We will ectopically introduce miR-124 and test the effect of miR-124 restitution on network activity and energetics using live-calcium imaging as well as the epigenomic and transcriptomic effects. Together this proposal represents the most in-depth analysis of miRNA function and will set the standard for future functional analyses of these molecules. Furthermore it has the potential to intervene in disease process and apply findings to a relevant human model providing a novel therapeutic target for the treatment of epilepsy.

Keywords: epilepsy,microrna,mir 124,epileptogenesis,epigenetics,transcriptomics,calcium imaging
TK210 ELISA – universal serum protein biomarker for cancer screening, diagnosis, treatment response monitoring and early detection of relapse (UNIBIO) (UNIBIO)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Sweden
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-09-01
End date: 2015-10-31
Duration (months): 2.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The UNIBIO project is a feasibility study for TK210 ELISA – a serum and plasma biomarker for cancer diagnosis and treatment response. Leveraging on the knowledge that cancer cells undergoing rapid growth produce and release into the blood abnormal amounts of protein called thymidine kinase (TK), AroCell has pre-validated a biomarker that quantifies the amount of TK protein directly in the serum in a blood sample. Current cell growth-related biomarkers are measured from tumour tissue, which limits their clinical utility. Recognizing a strong business opportunity, AroCell will propose TK210 ELISA as an easily-deployable and cost-efficient diagnostic and treatment-response test. The key need of clinicians and oncologists is the access to reliable biomarkers for the malignancy potential of cancer at diagnosis and effective monitoring of therapies. The test should make it possible to implement cost-efficient added information for diagnosis and follow-up. In the Phase 1 project, AroCell will perform a feasibility study verifying the clinical and economic viability of the clinical validation to be performed in the Phase 2 project. The EU added value of the project lies in the possibility to improve diagnostic accuracy using a minimally invasive diagnostic procedure based on the ELISA platform that is established within the EU Community.

Keywords: thymidine kinase tk,cell growth related biomarkers,elisa platform
MHC-I biogenesis and degradation at the endoplasmic reticulum membrane (MHCIbiopic)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-01
End date: 2021-01-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

One third of the cell proteome utilizes the secretory pathway for entrance into the endoplasmic reticulum (ER). However, the insertion of nascent proteins into or their translocation across the ER membrane, their maturation and assembly to oligomeric complexes and their degradation are very basic cellular processes of which we largely lack an integrative structural insight. I propose to use Cryo Electron Tomography (CET) to unravel the molecular mechanism of the biogenesis and degradation of Major Histocompatibility Complex-I (MHC-I) as a model substrate in situ. MHC-I are critical for immune responses to viruses and tumors. They are hetero-trimeric complexes formed by a light chain, a heavy chain and a variable cellular or microbial peptide. MHC-I folding is assisted by the chaperones ERp57 and calnexin at the ER membrane, where it assembles co-translationally, stabilized by tapasin. Once loaded with a peptide, MHC-I is exported to the cell surface for recognition by CD8+ T-cells. However, some viral immunoevasins like the human cytomegalovirus (HCMV) proteins US2 and US11 trigger the ER-Associated Degradation (ERAD) of MHC-I. I will combine data from CET, cross linking mass spectrometry (XL-MS) and in vitro functional assays on eukaryotic cellular and microsomal cell-free systems to provide an integrated picture of the complexes transiently involved in these processes. This work will make great contributions to our molecular understanding of cellular proteostasis and possibly provide novel molecular targets addressing diseases associated with ER stress. The proposed project will extend my knowledge from protein X-ray crystallography to the study of more complex molecular assemblies in association with membranes at larger length scales – ultimately the cell. Taken together, this project represents a unique opportunity to start blooming in my career as an independent researcher with a strong european network, and become a leader in the scientific community.

Keywords: cryo electron tomography,major histocompatibility complex class i,endoplasmic reticulum membrane,protein biogenesis,proteasomal degradation
Engineering Extremely Rare Events in Astrodynamics for Deep-Space Missions in Autonomy (EXTREMA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1972837.0
EU funding (EUR): 1972837.0
Participants: 1
Project status: SIGNED

A new space era is fast approaching. A multitude of miniaturised probes will soon permeate the inner solar system. The abundantly variegated minor bodies will be the destinations of numerous missions driven by exploration and exploitation needs. Missions to rocky planets will feature networks of artificial satellites to support science and operations. Yet, the state-of-the-art is to pilot deep-space probes from ground. Although this is reliable, ground control slots will saturate soon, thus hampering the current momentum in space exploration. EXTREMA enables self-driving spacecraft: machines able to travel in the deep space free of human-driven instructions. We take the challenge to make these systems a reality, and fundamental research is conducted to lay down their foundations. The ambition of EXTREMA is to prove that minor bodies and inner planets can be reached in a totally autonomous fashion with highly constrained platforms. These systems are used to engineer ballistic capture, an extremely rare event observed in highly sensitive regimes. To reinforce this logic, a new approach in orbit validation is introduced, which excels pure computer simulations. Erected over three pillars, the project forges a Simulation Hub, which reproduces on ground the spacecraft-environment interaction. While the pillars enable intermediate milestones, such as inferring the spacecraft position by exploiting the surrounding environment (autonomous navigation), self-determining a nominal plan without a-priori knowledge (autonomous guidance), and targeting the corridors that conduce to ballistic capture, it is the activity performed in the Simulation Hub that allows achieving the objectives via dedicated case studies. A successful outcome will boost access to outer space. The impact is to favour settlements in the inner solar system on a large-scale basis. Located at the fringe of research, EXTREMA can determine a paradigm shift in the way we conceive and conduct deep-space mission.

Keywords: astrodynamics,space trajectory design and optimisation,optical navigation,orbit control,autonomous guidance,navigation,and control,interplanetary cubesat,space engineering