Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Long-term performance of Engineered Barrier Systems (EBS) (PEBS)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Radioactive waste management
Destination: Management of Ultimate Radioactive Waste
Action type: Collaborative project
Countries involved: Germany,Switzerland,Sweden,Germany,Spain,Spain,Spain,France,Sweden,Japan,China
Call:  (FP7-Fission-2009, 2009)
Start date: 2010-03-01
End date: 2014-02-28
Duration (months): 48.0
Total project cost (EUR): 6525008.8
EU funding (EUR): 2806333.0
Participants: 18
Project status: CLOSED

The main aim of the project PEBS (Long-term Performance of the Engineered Barrier System) is to evaluate the sealing and barrier performance of the EBS with time, through development of a comprehensive approach involving experiments, model development and consideration of the potential impacts on long-term safety functions. The experiments and models cover the full range of conditions from initial emplacement of wastes (high heat generation and EBS resaturation) through to later stage establishment of near steady-state conditions, i.e. full resaturation and thermal equilibrium with the host rock. These aspects will be integrated in a manner that will lead to a more convincing connection between the initial transient state of the EBS and its long-term state that provides the required isolation of the wastes. The work proposed within the project builds on existing knowledge and experience generated during recent years and supported by ongoing nat. and EC research programmes. The project pretends to provide a more complete description of the THM and THM-C (thermo-hydromechanical-chemical) evolution of the EBS system, a more quantitative basis for relating the evolutionary behaviour to the safety functions of the system and a further clarification of the significance of residual uncertainties for long-term performance assessment. The importance of uncertainties arising from potential disagreement between the process models and the laboratory and in situ experiments to be performed within PEBS, and their implications for extrapolation of results will be reviewed, with particular emphasis on possible impacts on safety functions. In addition to the scientific-tech. aim, the consortium will spread the essential results to the european scientific community and Canada, Japan and China, use its expertise for public information purposes, and promote knowledge and technology transfer through training. WP 5 brings together activities concerning dissemination and training.

Keywords: final repository,engineered barrier systems,buffer,backfil,barrier performance,maboratory and field experiments,bentonit
Cooperation in education In Nuclear CHemistry (CINCH)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Support the development of nuclear competences at Union level and socio-economic aspects
Destination: Human Resources and training
Action type: Coordination and support actions
Countries involved: Czechia,Sweden,Finland,Russian Federation,France,Czechia,United Kingdom,Norway
Call:  (FP7-Fission-2009, 2009)
Start date: 2010-02-01
End date: 2013-01-31
Duration (months): 36.0
Total project cost (EUR): 1234752.03
EU funding (EUR): 804304.0
Participants: 8
Project status: CLOSED

The renaissance of nuclear power will require a significant increase of the numbers of the respective specialists, among others also nuclear chemists. Because the current situation in nuclear chemistry education and training in Europe is quite diverse, the project aims at its coordination. The system developed should enable formation of a long-term Euratom Fission Training Scheme (EFTS) providing a common basis to the fragmented activities in this field and thus move the education and training in nuclear chemistry to a qualitatively new level. The main target group will be not only the doctoral students and research workers but also the students at the master level. Including these students into the system should increase attractiveness of the studies of nuclear chemistry and thus enlarge the source of highly qualified professionals for the future employers. The envisaged consortium includes both academia and ‘future employers’, representatives of all the key players/countries in the field have been included. The EU experience will be faced with the Russian expertise; “Think-tank” activities will be organized for gathering the views as broad as possible. The experience gained by ENEN association during the coordination of nuclear engineering education will be directly applied, among others to design the common qualification criteria, the mutual recognition system, and in the development of a sustainable system of long-term financing of the scheme. The expected results of the project with the broadest impact to students, teachers, industries, and research community are a set of compact joint modular courses in different branches of modern nuclear chemistry, an electronic tool in the form of a virtual educational platform available for both education and training (both conceived as applicable at the Ph.D., life-long learning, and MSc. levels), and a long term sustainable strategy for the nuclear chemistry education including a roadmap for its implementation.

Keywords: nuclear chemistry,radiochemistry,education,training,coordination,modular course,e-learning
Evaluation and Viability of Liquid Fuel Fast Reactor System (EVOL)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Cooperation with Third Countries
Destination: Cooperation with Third Countries
Action type: Collaborative project
Countries involved: France,European organisations area,Netherlands,Germany,Germany,Italy,United Kingdom,Hungary,France,France,Czechia
Call:  (FP7-Fission-2009, 2009)
Start date: 2010-12-01
End date: 2013-11-30
Duration (months): 36.0
Total project cost (EUR): 1855883.8
EU funding (EUR): 995860.0
Participants: 13
Project status: CLOSED

An innovative molten salt reactor concept, the MSFR (Molten Salt Fast Reactor) is developed by CNRS (France) since 2004. Based on the particularity of using a liquid fuel, this concept is derived from the American molten salt reactors (included the demonstrator MSRE) developed in the 1960s. The major drawbacks of these designs were (1) a short lifetime of the graphite blocks, (2) a reactor fuelled with 233U, not a natural fissile isotope, (3) a salt constituted of a high chemical toxic element: BeF2, and (4) a fuel reprocessing flux of 4000 liters per day required reaching a high breeding gain. However, this concept is retained by the Generation IV initiative, taking advantages of using a liquid fuel which allows more manageable on-line core control and reprocessing, fuel cycle flexibility (U or Th) and minimization of radiotoxic nuclear wastes. In MSFR, MSR concept has been revisited by removing graphite and BeF2. The neutron spectrum is fast and the reprocessing rate strongly reduced down to 40 liters per day to get a positive breeding gain. The reactor is started with 233U or with a Pu and minor actinides (MA) mixture from PWR spent fuel. The MA consumption with burn-up demonstrates the burner capability of MSFR. The objective of this project is to propose a design of MSFR in 2012 given the best system configuration issued from physical, chemical and material studies, for the reactor core, the reprocessing unit and the wastes conditioning. By this way, demonstration that MSFR can satisfy the goals of Gen IV, in terms of sustainability (Th breeder), non proliferation (integrated fuel cycle, multi-recycling of actinides), resources (close U/Th fuel cycle, no uranium enrichment), safety (no reactivity reserve, strongly negative feedback coefficient) and waste management (actinide burner) will be done

Keywords: gen iv system innovative fast neutron reactor fuel processing molten salt chemistry high temperature materials
Tracing Amazon soil organic carbon input from land to the ocean (SOURCE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-04-01
End date: 2012-03-31
Duration (months): 24.0
Total project cost (EUR): 30000.0
EU funding (EUR): 30000.0
Participants: 1
Project status: CLOSED

Comprehensive knowledge about fluxes and processes related to the continental erosion and the subsequent delivery of organic carbon (OC) to the oceans via rivers is one of the priorities for a better understanding of the global carbon cycle. However, the fate of terrestrial OC in rivers as well as in the oceans is far from understood. In particular, the transport and transformations of soil OC in the oceans is poorly known although it is the largest terrestrial carbon pool. In this context, the overarching goal of the SOURCE project is to trace soil OC export across the land-ocean interface by applying newly developed techniques for soil OC tracers and by combining approaches from biogeochemistry, soil science, and oceanography. It is foreseen that this highly multidisciplinary research project will result in a more precise understanding of flux, age, and burial efficiency of soil OC at the land-ocean interface.

Keywords: biochemical and hydrological cycles,biogeochemistry,carbon cycle (climate change),soil erosion (climate change)
Converging Criteria for Consciousness: Using neuroimaging methods to characterize subliminal and conscious processing (NEUROCONSC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: France
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-07-01
End date: 2015-06-30
Duration (months): 60.0
Total project cost (EUR): 2486640.0
EU funding (EUR): 2486640.0
Participants: 1
Project status: CLOSED

We aim to find the limits of subliminal information processing and clarify the function and brain architecture underlying conscious processing in adults, infants, patients and non-human primates. (1) We will design experimental tests applicable to non-verbal organisms that can reveal behavioral and cerebral signatures of conscious processing. Those tests, respectively called rule extraction and central collision , each comprise an automatic sensory component and a central component thought to require conscious access. (2) Using these tests, we will identify brain signatures of non-conscious and conscious processing using neuroimaging techniques (ERPs, MEG, fMRI, intracranial recordings) in normal human adults. To validate our approach, we will manipulate stimulus perceptibility (masking), attention (distraction by another task) and vigilance (sleep and anesthesia). (3) We will then extend the approach to brain-damaged adults with coma, persistent vegetative state or minimal consciousness, in order to detect residual processing and to obtain predictors of recovery. We will design computer systems to extract signatures of conscious processing in real time. (4) We will also examine when these signatures first appear in human infancy. (5) Finally, we will measure fMRI activation in monkeys during the same tests, thus allowing for a direct comparison of monkey and human signatures of conscious processing. We will study the effects of anesthesia on the loss of these signatures, and the potential beneficial impact of thalamic stimulation on their restoration. This research will clarify the brain mechanisms of conscious processing, illuminate their ontogeny and phylogeny, and pave the way to clinical intervention studies in patients with impaired consciousness.

Keywords: consciousness,neuroimaging,human brain,development.
Emotional interaction grounded in realistic context (TANGO)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Future and emerging technologies
Action type: Collaborative project
Countries involved: Netherlands,Germany,Switzerland,Israel,France,Germany,Italy
Call:  (FP7-ICT-2009-C, 2009)
Start date: 2010-04-01
End date: 2013-03-31
Duration (months): 36.0
Total project cost (EUR): 3592890.0
EU funding (EUR): 2784999.0
Participants: 7
Project status: CLOSED

Many everyday actions take place in a social and affective context and presuppose that the agents share this context. But current motion synthesis techniques, e.g. in computer graphics, mainly focus on physical factors. The role of other factors, and specifically psychological variables, is not yet well understood. The goal of the TANGO project is to take these familiar ideas about affective communication one radical step further by developing a framework to represent and model the essential interactive nature of social communication based on non- verbal communication with facial and bodily expression. TANGO will investigate interactions in real life contexts showing agents in daily situations such as navigation and affective communication. A central goal of the project is the development of a mathematical theory of emotional communicative behaviour. Theoretical developments and investigations of the neurofunctional basis of affective interactions will be combined with advanced methods from computer vision and computer graphics. Emotional interactions can be studied quantitatively in detail and can be transferred in technical systems that simulate believable emotional interactive behaviour. Based on the obtained experimental results and mathematical analysis, a new generation of technical devices establishing emotional communication between humans and machines will be developed. TANGO goes beyond the state of the art in theoretical scope, in methodological approaches and in innovative applications that are anticipated.

Keywords: social communication,affective information,interaction,realistic context,avatars,human-computer interaction,mathematics
Linking ecological and evolutionary dynamics in theory, in the lab and in the field (LEED)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Evolutionary, population and environmental biology
Countries involved: United Kingdom,United Kingdom
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-06-01
End date: 2015-05-31
Duration (months): 60.0
Total project cost (EUR): 2053934.92
EU funding (EUR): 2053934.92
Participants: 2
Project status: CLOSED

Population biologists do not have a well-developed quantitative framework that links ecological and evolutionary dynamics in variable environments. Recent advances in stochastic demography and evolutionary biology mean that the formulation of a general quantitative framework is now within reach. The objective of this proposal is to develop this framework and to apply it to a laboratory and a field system. The key to linking evolutionary and population dynamics in variable environments is to understand what processes drive the dynamics of heritable phenotypic traits. I have developed methods to exactly decompose observed phenotypic change in structured populations living in variable environments. I will build on this research to develop predictive theory. The work will help unify ecology and evolutionary biology, and allow biologists to make predictions on the consequences of environmental change for the natural world. Theory can be used to explain observed change or make testable predictions. The theory I will develop will be applied to two systems bulb mites in the laboratory and wood mice in the field. Application to the bulb mite system will provide general insight into processes that maintain phenotypic and genetic diversity in stochastic, density-dependent environments, and will specifically explain why a heritable morphological character is maintained in bulb mites. In applying the theory to an established rodent field study I will utilise new, powerful technology that will allow researchers to monitor free-living animals in unprecedented detail. The field study will provide insight into eco-evolutionary dynamics in a natural setting, and on the management and conservation of a group of animals of public health, economic and ecological importance.

Keywords: stochastic demography,quantitative genetics
Combined time domain and spectral domain coherence gating for imaging and biosensing (COGATIMABIO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: United Kingdom
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-05-01
End date: 2015-10-31
Duration (months): 66.0
Total project cost (EUR): 1999241.0
EU funding (EUR): 1999241.0
Participants: 1
Project status: CLOSED

Revolutionary combination of principles of spectral domain and time domain coherence gating will be researched. The present proposal puts forward: (i) a novel class of optical interferometers, (ii) a novel class of wavefront sensors and (iii) combinations of imaging channels with the novel wavefront sensors. All these are driven by the needs to address the limitations in terms of speed of the time domain (TD) optical coherence tomography (OCT), in terms of range, resolution and focus of the spectral (SD) OCT methods and in terms of spatial resolution of wavefront sensors. A new class of OCT systems is researched, as a marriage between the TD-OCT and SD-OCT methods. The novel methods present the generality of being compatible with both TD-OCT and SD-OCT. It is envisaged that the research results will revolutionise the field of high resolution imaging and high sensitive sensing and open applications not currently possible with the present OCT, confocal microscopy or multiphoton microscopy technology. The method to be researched will allow versatile functionality in measurements, in 3D imaging of moving tissue and functional/low noise imaging by making use of angular compounding or polarisation. Novel directions are opened in the tracking of the axial position of objects (cornea or retina), automatic dispersion compensation as well as improvement in the synchronism between the coherence gate and the focus in axial scanning. Simultaneous measurements over multiple path lengths becomes feasible, with potential applications in high throughput sensing. The methods proposed open novel avenues in biosensing by amplification of tiny frequency shifts or tiny changes in the optical paths. Possible outcome are high sensitive biosensors, multiple imaging at different depths, fast and long range tracking, long axial scanning, coherence gated wavefront sensors with applications in vision sciences and microscopy, protein identification and contrast agents developments.

Keywords: high throughput sensing,protein recognition,eye tracking,vision research,high resolution imaging,wavefront sensing
Development of high throughput in vivo oncogenomic screening strategies in acute leukaemia (ONCOGENOMICS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: United Kingdom
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-05-01
End date: 2016-04-30
Duration (months): 72.0
Total project cost (EUR): 2249439.7
EU funding (EUR): 2249439.7
Participants: 1
Project status: CLOSED

Within a highly successful research environment, we will develop a state-of the-art high throughput functional in vivo oncogenicity assay, using mouse bone marrow transplant models of leukaemia to conclusively identify the important genetic changes involved in the development and progression of cancer. This study will focus on B-lineage acute lymphoblastic leukaemia (ALL), for which there is a wealth of knowledge on the biology of the disease. Our aim will be to differentiate between driver and passenger genes, when other techniques have implicated large numbers of candidates. Initial areas of focus will be 1) to determine the gene(s) involved in patients with the poor risk subtype of ALL, iAMP21, so that these may be specifically targeted by molecular therapy. This is important to reduce the high level of toxic treatment required to prevent relapse in these patients; 2) to definitively identify tumour suppressor genes within the deleted region of chromosome 6. Patients with this abnormality comprise a high proportion of ALL and non Hodgkin s lymphoma (NHL), particularly childhood T-lineage NHL, where it is linked to a poor prognosis; 3) to identify and characterise those genes involved in drug resistance leading to relapse. Candidate tumour suppressor genes associated with relapse have already been implicated. Comprehensive sequencing of further samples will identify additional mutated genes. The ultimate aim is to determine the clinical relevance of these abnormalities and develop molecular genetic assays suitable for routine clinical detection, with a view to validating their role as molecular targets for therapy; a particular strength of my group. In the future this methodology will be extended to the detection of genes in other haematological malignancies.

Keywords: cancer,genes,drug targets
Eradication of tumors by targeting dsRNA selectively to cancer cells and recruitment of the innate immune system (TARGETING_CANCER)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: Israel
Call:  (ERC-2009-AdG, 2009)
Start date: 2010-02-01
End date: 2015-01-31
Duration (months): 60.0
Total project cost (EUR): 2054340.0
EU funding (EUR): 2054340.0
Participants: 1
Project status: CLOSED

We have recently shown that EGFR over-expressing tumors can be eradicated by an EGFR homing chemical vector, carrying dsRNA. The vector is PolyInosine/Cytosine (PolyIC) bound to Polyethleneimine-Polyethyleneglycol-EGF (PEI-PEG-EGF, PPE). We have shown that even tumors in which up to 50% of cells do not express EGFR are eradicated, due to the strong tumor-localized bystander effects, which involve the innate immune system. Using this EGFR homing vector we have been able to eradicate EGFR overexpressing tumors by either local or systemic application. Since the success of this strategy seems to be due to the strong bystander effects induced by the internalized PolyIC it is likely that heterogeneous tumors, in which only a portion of the cells harbor the targeted receptor, will be eradicated too, as shown in our preliminary studies (PloS Med, 2006). This strategy actually targets the innate immune system to the tumor. We propose to establish tumors in which decreasing portions of cells over-express EGFR and determine the lowest number of EGFR over-expressing cells that can yield tumor eradication by the lowest dose of PolyIC/PPE. The principle behind the success of the Trojan horse approach is that the targeting moiety, EGF, is tethered to the other components of the vector in such a way that it retains its native EGFR binding properties and its ability to internalize with the receptor. The composition of the vector is such that the ligand EGF can be replaced by any other ligand, if the appropriate coupling conditions are used, retaining the ability of the ligand to bind to the target protein and internalize with it. We propose to replace EGF by a number of other ligands, such PSMA binding ligand (targeting prostate cancer) and Her-2 affibodies. Although only a fraction of women who over-express Her-2 respond to Herceptin, it is likely that they will respond to PolyIC/PP-Her-2 affibody.

Keywords: cancer,innate immunity,poly ic