Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
This 3 day conference will be focused to the financial instruments, facilities and measures launched under Horizon 2020 to enhance access to finance for research, innovation and SMEs. (First InnovativeWeek)

Framework: Horizon 2020 — Industrial Leadership
Programme: Access to risk finance
Action type: Coordination and support actions
Countries involved: Latvia
Call: RISK FINANCE (H2020-Adhoc-2014-20, 2015)
Start date: 2015-02-02
End date: 2015-12-01
Duration (months): 10.0
Total project cost (EUR): 350000.0
EU funding (EUR): 350000.0
Participants: 1
Project status: CLOSED

The overall aim of the project is a 3 day High level international conference, which will raise awareness of the potential for the financial instruments and accompanying measures launched under Horizon 2020 to enhance access to finance for research, development and innovation. The role of the preparation of the investment project provided by Innovfin advisory will be outlined in compliance with the Political guidelin announced by President Juncker.A special attention will be given to concrete measures supporting innovative SMEs. A particular focus will be the possible interactions between Horizon 2020 financial instruments, COSME's, and European Structural & Investment Funds (ESIF), as well as with instruments at national and regional level. The event will bring together policy-makers, financial intermediaries and representatives of the research, innovation and business communities. The specific objectives of the conference are:Firstly, help businesses and other types of organisation engaged in research and innovation (R&I) to better understand how to gain access, via financial instruments, to loans, guarantees, counter-guarantees and hybrid, mezzanine, equity finance and non-banking initiatives supporting R&I.Secondly, exchange views on the implementation of Horizon 2020 financial instruments (innovfin large, innovfin midcap guarantee, innovfin mid-cap growth finance, innovfin SME guarantee, and Innovfin SME VC) and accompanying measures (innovfin advisory). Thirdly, improving the up-take of new Horizon 2020 financial instruments such as the SME Finance Initiative; the launch of a pilot facility supporting the technology transfer process; and new focuses on major societal challenges in the field of energy and infectious diseases. Finally, the European Investment Bank (EIB) and the European Investment Fund (EIF) will participate in this conference and provide their role, as entrusted entities, in charge of the implementation of Horizon 2020 financial instruments.

Keywords: the conference will bring together high level policy makers,financial intermediaries and representatives of the research,innovation and business communities
The Annotation and Functional Description of Non-Model Bacterial Organisms for Bio-based Engineering and Industry (HOPE-4-BEST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-10-14
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

The project “The Annotation and Functional Description of Non-Model Bacterial Organisms for Bio-based Engineering and Industry (HOPE-4-BEST)” aims to bring new bioinformatics and systems biology tools for a comprehensive description of little studied microorganisms and inference of biological knowledge further utilizable in synthetic biology for engineering of industrially utilizable bacterial strains. Bacteria form the largest group of organisms in the world. Since the DNA and RNA sequencing became widely available, they begun to be often studied on molecular level for their exceptional biological properties, e.g. ability to produce fuels or plastics from waste. Unfortunately, previous lack of interest in their research is the source of many obstacles in bioinformatics and systems biology data processing as current tools, designed primarily for eukaryotic model organisms, cannot be easily used for processing data gathered from non-model bacterial organisms. Inference of biological knowledge presumes identification of regulated genes and annotation of their molecular function so involved biological processes could be captured. The project addresses two important questions, how to assemble a comprehensive functional annotation for non-model organisms and how it affects inferred biological knowledge. This will be achieved by designing novel pipeline utilizing transcriptome wide analysis based on comparison of samples under various conditions while considering data bias, e.g. multimapping reads or overlapping genes, and its combination with annotation build by extensive database searching. Eventually, the successful solution of the project will not only substantially contribute to our understanding how various parameters of bioinformatics data processing and annotation affect resulting biological knowledge, but will provide ready-to-use solution for wide scientific community.

Keywords: mathematical aspect of biology,microbiology,biofuels and bioplastics
OIT3: A novel Magnesiotropic Gene in Kidney (OMG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United States,Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2023-10-16
Duration (months): 36.0
Total project cost (EUR): 253052.16
EU funding (EUR): 253052.16
Participants: 3
Project status: CLOSED

Mg2+ is the second most abundant intracellular cation after potassium and it plays an essential role in the human body. The kidney is the key organ regulating Mg2+ homeostasis through complex processes of excretion and reabsorption. This takes place in the nephrons, the functional units of the kidney, via paracellular mechanisms and ion transporters. Alterations in Mg2+ homeostasis are associated with several diseases and vice versa. Hypomagnesemia (serum Mg2+ <0.70 mmol/L) is the most common form of Mg2+ disturbance which can be due to impaired intestinal Mg2+ absorption or renal Mg2+ wasting. Remarkably, hypomagnesemia is associated with highly prevalent metabolic disorders including diabetes and metabolic syndrome. In the past, many genetic causes of hypomagnesemia and renal Mg2+ wasting have been identified in humans, encompassing mutations in magnesiotropic genes. This has been crucial to decipher part of the mechanisms involved in Mg2+ transport and renal (patho)physiology. However, many cases of Mg2+ disturbances cannot be explained with the current knowledge, meaning that there is a clinical need to further elucidate the mechanisms underlying hypomagnesemia to find an effective treatment. Recently, we have discovered OIT3, a new gene involved in Mg2+ handling. However, the mechanisms of action and its physiological role need to be deciphered. The aim of the present project is to unravel the physiological role and mechanisms of action of OIT3 in relation to Mg2+ handling as well as find clinical indications from human kidney disease where OIT3 can play a role. Applying a wide range of techniques including electrolyte analysis, advanced microscopy, RNAseq and bioinformatics, I will provide mechanistic insights and a holistic view into the role of OIT3 in renal Mg2+ homeostasis. This approach will contribute to the discovery of potential therapeutic targets and biomarkers of electrolyte-related kidney disease.

Keywords: transgenic organisms
Zero sets of random functions (RandomZeroSets)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Israel
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2023-09-30
Duration (months): 84.0
Total project cost (EUR): 1658750.0
EU funding (EUR): 1658750.0
Participants: 1
Project status: SIGNED

The proposed research is focused on zero sets of random functions. This is a rapidly growing area that lies at the crossroads of analysis, probability theory and mathematical physics. Various instances of zero sets of random functions have been used to model different phenomena in quantum chaos, complex analysis, real algebraic geometry, and theory of random point processes. The proposal consists of three parts. The first one deals with asymptotic topology of zero sets of smooth random functions of several real variables. This can be viewed as a statistical counterpart of the first half of Hilbert's 16th problem. At the same time, it is closely related to percolation theory. In the second and third parts, we turn to zero sets of random analytic functions of one complex variable. The zero sets studied in the second part provide one of few natural instances of a homogeneous point process with suppressed fluctuations and strong short-range interactions. These point processes have many features, which are in striking contrast with the ones of the Poisson point process. One of these features is the coexistence of different Gaussian scaling limits for different linear statistics. The third part deals with zeroes of Taylor series with random and pseudo-random coefficients. Studying these zero sets should shed light on the relation between the distribution of coefficients of a Taylor series and the distribution of its zeroes, which is still "terra incognita'' of classical complex analysis.

Keywords: complex analysis,real and harmonic analysis,probability theory,quantum chaos,mathematical physics
Integrated and innovative key actions for mycotoxin management in the food and feed chain (MycoKey)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Argentina,Italy,Ukraine,Italy,Serbia,Belgium,China,Switzerland,Belgium,Switzerland,Türkiye,Finland,Romania,Belgium,France,France,France,Netherlands,Nigeria
Call: Biological contamination of crops and the food chain (H2020-SFS-2015-2, 2015)
Start date: 2016-04-01
End date: 2020-10-31
Duration (months): 55.0
Total project cost (EUR): 6384521.25
EU funding (EUR): 4953160.0
Participants: 33
Project status: CLOSED

MycoKey aims to generate innovative and integrated solutions that will support stakeholders in effective and sustainable mycotoxin management along food and feed chains. The project will contribute to reduce mycotoxin contamination mainly in Europe and China, where frequent and severe mycotoxin contaminations occur in crops, and where international trade of commodities and contaminated batches are increasing. MycoKey will address the major affected crops maize, wheat and barley, their associated toxigenic fungi and related mycotoxins (aflatoxins, deoxynivalenol, zearalenone, ochratoxin A, fumonisins). The project will integrate key information and practical solutions for mycotoxin management into a smart ICT tool (MycoKey App), providing answers to stakeholders, who require rapid, customized forecasting, descriptive information on contamination risk/levels, decision support and practical economically-sound suggestions for intervention. Tools and methodologies will be strategically targeted for cost-effective application in the field and during storage, processing and transportation. Alternative and safe ways to use contaminated batches will be also delivered. The focus of Mycokey will be: i) innovating communications of mycotoxin management by applying ICT, providing input for legislation, enhancing knowledge and networks; ii) selecting and improving a range of tools for mycotoxin monitoring; iii) assessing the use of reliable solutions, sustainable compounds/green technologies in prevention, intervention and remediation. The multi-disciplinary consortium, composed by scientific, industrial and association partners (32), includes 11 Chinese institutions and will conduct the 4 years programme in a framework of international networks.

Keywords: mycotoxins,maize,wheat,barley,aflatoxins,deoxynivalenol,zearalenone,fumonisins,ochratoxin a,detection tool kits,feed additives,sustainability,risk monitoring,risk characterization
SN: The first blood biomarker to accurately STratify mortality Risk In patients with Cardiac arrhyTmia (STRICT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Norway
Call: European SME innovation Associate - pilot (H2020-INNOSUP-2019-02, 2019)
Start date: 2019-12-15
End date: 2020-12-14
Duration (months): 12.0
Total project cost (EUR): 119805.0
EU funding (EUR): 119805.0
Participants: 1
Project status: CLOSED

Cardiovascular disease (CVD) is the no. 1 killer worldwide. 25% of all CVD mortality is caused by ventricular arrhythmias that lead to sudden cardiac death (SCD). The diagnosis of arrhythmias is difficult but crucial for accurate decision-making and patient survival. To assess the patient’s status, cardiologists currently ask: physical exams, some cardiac biomarkers data, an ECG (which may detect an arrythmia) and an echocardiogram to measure the blood ejection from the left ventricle (LVEF), since there is a correlation between LVEF and risk of ventricular arrhythmias. If LVEF is < 35%, the patient is eligible for implantable cardioverter-defibrillator (ICD) surgery, which costs at least 20K€. Still, around 51 % of victims of SCD have normal LVEF. In addition, 67% of all implemented ICDs are never activated because those patients were (unknowingly) at low-risk for arrhythmias, which represents a 1.3B€ overtreatment cost / year in the EU alone. CardiNor is bringing to market a new in vitro diagnostic (IVD) test to measure blood levels of Secretoneurin (SN), a globally patented biomarker and the only one shown to be specifically linked to ventricular arrhythmias. With SN data, cardiologists will be able to stratify patients according to their risk as well as to pinpoint high-risk patients not identified by the current diagnostic regime, thus reducing health burden costs and saving lives. CardiNor needs the SME Innovation Associate Programme to boost R&D activities within test maturation and effectively take it to TRL8. Currently, we do not have in-house expertise in biomedical device development or quality assurance. Therefore, we are looking to recruit an Innovation Associate. Acquiring these skills is important for CardiNor to maintain competitive advantage over coming years, positioning our company to high growth in the global CVD biomarkers market.

Keywords: cardiac and cardiovascular systems,biomarkers,diagnostic tools,secretoneurin,ventricular arrythmias,in vitro diagnostics,elisa,risk stratification,icd selection,cost savings
Realizing the Potential of the Transients Boom: A Consolidated Study of Stellar Demise (StarDestroyers)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Israel
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-07-01
End date: 2025-06-30
Duration (months): 60.0
Total project cost (EUR): 1998625.0
EU funding (EUR): 1998625.0
Participants: 1
Project status: SIGNED

How do massive stars evolve and achieve explosion? What governs the various regimes of accretion physics? What is the population of quiescent supermassive black holes? What is the neutron star equation of state? These seemingly unrelated questions (among others) can be answered through the study of transients, mainly: supernovae (SNe), tidal disruption events (TDEs), and kilonovae (KNe). For this reason, an enormous amount of observational effort is being put into surveys to discover more of these rare events. The bottleneck is now in identifying the transients of value in ever-growing alert streams, and in performing prioritized wide-scale followup. Without these crucial steps, which cannot be done retroactively after the transient surveys are concluded, we will not gain full access to the broad underlying physics, regardless of the quantity of events discovered. Here I propose to develop and use novel tools to consolidate discoveries from various transient surveys, identify the events that demand immediate followup, prioritize followup resources, and conduct the followup, all in real time. My experience with prominent transient surveys and followup facilities allowed me to obtain some of the most comprehensive observations of young SNe, identify the first class of optical TDEs and their unique host-galaxy preference, and lead the discovery team that secured the densest early data of the first KN following a gravitational-wave trigger. I now have access to a unique combination of observing resources that will allow me to transform these discoveries from the few events level to statistical samples. The public ZTF survey is already producing 100,000 alerts per night. LSST is around the corner, and is expected to produce 10 million alerts per night. Now is the time to invest in identification, classification, and followup of the potential treasure chest of events provided by transient surveys in order to unlock the broad range of physical insights we gain from them.

Keywords: pacs2010 97 10 me mass loss and stellar winds,97 60 bw supernovae,97 60 jd neutron stars,98 62 js galactic nuclei,circumnuclear matter,and bulges,95 75 rs remote observing techniques
Understanding the drivers and impacts of homicides in 4 major Latin American cities. (HomicidesLACcities)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2023-01-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

This project will seek to better understand the drivers and effects of homicides in 4 major Latin American cities (Bogotá, Medellín, Cali and Mexico City) with of focus on the differential impacts on vulnerable groups especially women, while allowing an experienced French researcher—Emmanuel Letouzé—having acquired solid credentials in leading US universities and global forums to contribute to Europe’s standing in data-driven social science and policymaking. Building on the researcher’s rich interdisciplinary background, past and ongoing related work on conflict and crime, and deep international network and experience, the project will draw on the resources and expertise of UPF’s Faculty of Political and Social Sciences, Jorge Rodriquez, John Palmer, and Sebastian Sarasa, to yield 4 scientific papers and a synthesis monograph along with supporting tools and activities on homicide dynamics in these cities, with broader applicability to other regions. In particular, the researcher will leverage ‘Big Data’ sources such as cell-phone data from a major Spanish telecom operator—Telefónica— and Spanish Bank (BBBVA), in combination with official statistics on economic conditions and homicides and structural open urban data to shed light on 2 main research questions: (1) what are the key factors that seem to be driving homicides in these cities? (2) How do homicides affect the daily behaviors of affected communities and groups especially women? In the medium term, this project will seek to pave for the way for a network of European regional urban laboratories dedicated to making cities safer and fairer around the world.

Keywords: homicides,big data,impacts,drivers,latin america
Challenging current models of valence encoding in the mammalian brain (VALENCE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Portugal
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 1988266.0
EU funding (EUR): 1988266.0
Participants: 1
Project status: SIGNED

In an ever-changing environment, organisms evolved to filter information and focus on stimuli that are associated with relevant outcomes. Even the simplest animals assign valence to otherwise neutral stimuli in order to survive. A positive (rewarding) valence stimulus elicits approach, whereas a negative (aversive) valence stimulus supports avoidance behaviors. Decades of research revealed that some regions of the limbic system encode valence, including the nucleus accumbens (NAc), which is considered a prime candidate to interface valence and behavior. The NAc is mostly composed of GABAergic medium spiny neurons (MSNs), divided into those expressing dopamine receptor D1 and dynorphin, and those expressing D2 and enkephalin. D1 and D2 neurons were assumed to encode opposing valence, but recent data by us and others revealed this model to be overly simplistic. That is - to date, it is still not known how valence is encoded in this region. The main goal of this project is to determine how NAc neurons encode valence. Based on preliminary data, we hypothesize that valence is encoded by distinct patterns of MSN activity. These patterns differentially signal via GABA and opioids (dynorphin, enkephalin), triggering rewarding/aversive behaviors. To test this hypothesis, we will record neuronal activity of rodents performing tasks with opposing valences, in combination with time- and spatially-resolved analysis of opioidergic transmission, using newly-developed opioid fluorescent sensors. This information will then be used to mimic/block patterns of MSN activity and opioid events in order to show causality. This cutting-edge approach will unravel with unparalleled accuracy how NAc encodes valence, the role of endogenous opioids, and how these signals are decoded in the circuit to drive behavior. VALENCE is a frontier opening project that will answer long-standing questions in the field, deepening the knowledge on how the mammalian brain encodes rewarding and aversive events.

Keywords: valence,reward,aversion,nucleus accumbens,opioids,behavior