Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PRECISION CARE IN SYSTEMIC AUTOIMMUNITY: AN INTEGRATED MULTI-TISSUE/LEVEL APPROACH FOR SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) (LUPUSCARE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Greece
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 2355000.0
EU funding (EUR): 2355000.0
Participants: 1
Project status: SIGNED

Systemic lupus erythematosus (SLE) is a heterogeneous disease whereby an interplay of environmental, genetic and epigenetic factors lead to perturbation of complex biological networks culminating into diverse clinical phenotypes of varying severity. High throughput methods have allowed an “initial glimpse” into pathogenesis and have laid the foundations for a molecular-based taxonomy for personalized therapy. Based on our experience with the molecular characterization of SLE, a recently completed RNA sequencing analysis of 150 patients, and our track- record of “paradigm shift” trials in SLE, we will integrate data from multi-tissue analyses with novel technologies to improve its diagnosis, monitoring and therapy, and ask fundamental pathogenetic questions in systemic autoimmunity. More specifically, we will design gene expression panels and “expression profile”/”clinical trait” correlation matrices for diagnostics, personalized immunotherapy and improved clinical trial design. In a systematic multi-tissue approach, we will examine the role of somatic mutations in enhancing immune hyperactivity and the risk for lymphoma. The staggering (7-9:1) female predominance will be elucidated through elaborate genomic, epigenomic and microbiota analyses of family trios. Finally, we will be pursuing the innovative hypothesis that the fundamental abnormalities of SLE lie within the bone marrow hematopoietic stem cells (HSCs) - from which all cells that participate in the pathogenesis of SLE originate - and establish it as a unifying pathogenetic mechanism. By a combination of novel experimental analyses with single cell genomics, multi–omics, humanized animal models, genome editing and an “organ on-a-chip” device, we will validate HSCs as a therapeutic target. The utility of SLE research extends beyond its boundaries, by providing unique insights as to how the immune system recognizes self-constituents and maintains its homeostasis, and how gender impacts on disease biology.

Keywords: autoimmunity,genomics,molecular taxonomy,epigenetics,personalized therapy
Unlocking self-patterning competence to engineer 3D human spinal cord (3DHumanSpinalCord)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

Organizers direct formation of the body, releasing morphogens to position tissues and organs. But what organizes the organizers? I aim to harness organizer formation to build self-patterning 3D human spinal cord in vitro. In developing spinal cord, the floorplate organizer secretes Sonic Hedgehog to direct ventral-dorsal patterning. Prof Tanaka (secondment) discovered how to recapitulate this in vitro: single mouse naïve pluripotent stem cells (PSCs) form neural tube organoids and an early pulse of retinoic acid prompts self-organization of floorplate that drives patterning as in vivo. However, attempts to form cognate human organoids have been unsuccessful. There is a restricted window of competence to initiate floorplate formation, which conventional primed human PSCs are unable to access. To overcome this, I will combine microenvironment bioengineering with new naïve human iPSCs (Prof Elvassore, host) to recapitulate and study human development from an earlier stage, gaining access to molecular events that may underpin later fate specification and tissue organization. By mechanistic analysis in mouse organoids, I will reveal how competence is instated, how it is closed, and how to prolong or re-instate competence de novo. This knowledge will guide me in unlocking the competent state for human PSCs in vitro, and has implications for activating spinal cord regeneration in vivo. By use of sophisticated engineering technologies pioneered in the Elvassore group, I will control the micro-environment to guide tissue growth and formation, mimicking natural physiology and ensuring reproducibility. By engineering 3D organized human spinal cord in vitro, this project will bridge basic knowledge of critical and inaccessible stages of human development with future biomedical applications. This interdisciplinary training opportunity will build on my doctoral expertise in PSC identity transitions, setting me apart with a strong independent niche for my future career.

Keywords: microenvironment bioengineering,microfluidics,organizers,spinal cord patterning,organoids
Eyes of Things (EoT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: A new generation of components and systems: Engineering of advanced embedded and energy and resource efficient components and systems
Action type: Innovation actions
Countries involved: Germany,Austria,Germany,Ireland,Ireland,Spain,Switzerland,France,Portugal
Call: Smart Cyber-Physical Systems (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2018-06-30
Duration (months): 42.0
Total project cost (EUR): 4932280.0
EU funding (EUR): 3734830.0
Participants: 10
Project status: CLOSED

Vision, our richest sensor, allows inferring big data from reality. Arguably, to be “smart everywhere” we will need to have “eyes everywhere”. Coupled with advances in artificial vision, the possibilities are endless in terms of wearable applications, augmented reality, surveillance, ambient-assisted living, etc. Currently, computer vision is rapidly moving beyond academic research and factory automation. On the other hand, mass-market mobile devices owe much of their success to their impressing imaging capabilities, so the question arises if such devices could be used as “eyes everywhere”. Vision is the most demanding sensor in terms of power consumption and required processing power and, in this respect, existing mass-consumer mobile devices have three problems: 1) power consumption precludes their ‘always-on’ capability, 2) they would have unused sensors for most vision-based applications and 3) since they have been designed for a definite purpose (i.e. as cell phones, PDAs and “readers”) people will not consistently use them for other purposes. Our objective in this project is to build an optimized core vision platform that can work independently and also embedded into all types of artefacts. The envisioned open hardware must be combined with carefully designed APIs that maximize inferred information per milliwatt and adapt the quality of inferred results to each particular application. This will not only mean more hours of continuous operation, it will allow to create novel applications and services that go beyond what current vision systems can do, which are either personal/mobile or ‘always-on’ but not both at the same time. Thus, the “Eyes of Things” project aims at developing a ground-breaking platform that combines: a) a need for more intelligence in future embedded systems, b) computer vision moving rapidly beyond academic research and factory automation and c) the phenomenal technological advances in mobile processing power.

Keywords: computer vision,machine vision,embedded vision
Links between warming Arctic and climate extremes in northern Eurasia (LAWINE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Finland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-01
End date: 2019-01-31
Duration (months): 24.0
Total project cost (EUR): 191325.6
EU funding (EUR): 191325.6
Participants: 2
Project status: CLOSED

During last three decades, the Arctic has warmed faster than rest of the planet going through unprecedented physical changes as manifested by the record low sea-ice and snow areas in summer. Impacts of these changes on weather and climate outside the Arctic region, such as in northern Eurasia, might be substantial because the Arctic is an integral part of the global climate system. Potentially associated with Arctic warming, an increased occurrence of extreme events, such as heat waves, exceptionally cold winters and flooding, often of unprecedented strength and duration, has already been observed in the Northern Hemisphere during the last decade. Our main motivation is to reduce the potential damage by extreme climate events. For this, we propose to investigate teleconnections linking the ocean and land surface characteristics to the occurrence of extremes. We hypothesise that Arctic warming is affecting Eurasian climate extremes by teleconnections along with other regions, such as the North Atlantic and Pacific. However, our understanding of mechanisms of teleconnections is incomplete due to imperfect models and sparse observations. To address this gap, we will compare observations and climate model output and select the most realistic models in terms of their ability to represent teleconnections. To investigate mechanisms, we configure and execute climate model simulations. Results of our work will be used to improve models' prediction skill and to reduce uncertainties related to estimates of changes in climate extremes in Eurasia. The experienced researcher, Prof. Uotila, has an extensive experience in climatological research focused on the Southern Hemisphere using methods closely related to the ones proposed for this work. His supervisor, Prof. Vihma, is a leading expert in polar meteorology and climatology. Their partnership would help Uotila to integrate in the European climate research community.

Keywords: sea ice,heat,cold,flood,draught
Next Generation of SMARt Active Inceptor for Tilt Rotor Application (SMAR-TeR)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Italy,Germany,Italy
Call: Smart Active Inceptors System definition for Tilt Rotor application (H2020-CS2-CFP09-2018-02, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 1309293.75
EU funding (EUR): 1309293.75
Participants: 5
Project status: CLOSED

The SMAR-TeR project is aimed at identifying, developing, prototyping and pilot-in-the-loop validating a new class of active inceptors for civil tilt rotor application. The design will focus on inceptors’ mechanical interfaces and ergonomics so that NGCTR FCS augmentation can be further improved. At the same time studies on ergonomics, electromechanical senso-actuators, haptic capabilities, command logic including diagnostic capabilities and system integration by pilot-in-the-loop simulation at WAL premises will be part of SMAR-TeR commitment. The first step will consist in a specification review, a conceptual system design, trade-off activities and a technological innovation assessment with the final aim to identify the possible ergonomic architectures that match the WAL requirements and the tilt rotor specific application. Virtual reality based and 3D-printed methods will be used in order to define the best inceptor ergonomic architecture and functionality to improve the pilot and co-pilot comfort and workload reduction. Innovative inceptor with “haptic capabilities” will be implemented by developing software and hardware solutions in order to define an active inceptor systems that feeds information from the tiltrotor’s fly-by-wire system to the pilot through the inceptor itself. This “tactile cueing” will be one of the many benefits of the proposed active inceptor system. Algorithms modelling, simulation and performance analysis will be carried out in order to develop a new worldwide state of art inceptor for tiltrotor application. The system will be designed, produced and tested keeping in mind current trends in pilot haptic aiding that go beyond the variable stiffness or passive haptic aids characteristics currently adopted; the proposed hardware and software architecture will allow adoption of future active haptic aids. The final three inceptors’ configurations will be tested at WAL facilities in order to define the inceptor specification.
Popularitas : pursuit of consensus and populism in ancient Rome (POPULARITAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The Popularitas project aims to provide a comprehensive study of the precedents of populism in ancient Rome. The Latin adjective popularis had a passive meaning (the man who enjoys the favour of the people), but also an active one (the man who seeks the favour of the people). Sometimes this active meaning was employed in connection with ambitious outsiders, wannabe “charismatic” leaders, who took a perspective hostile to the senatorial elite, claimed to have a direct connection with the people, and exploited this connection in order to bypass the institutions, to subvert the constitutional rules, and to gain power. The object of the project is precisely this political attitude, where the legitimate seeking of consensus turned into populism: what are the similarities and differences between ancient and contemporary populism? how far the allegations against ancient populists were well-founded? did populistic attitudes have ideological implications? to what extent populistic methods were effective? what was the people’s feedback? The main output of the project will be the publication of a monograph on the populism in ancient Rome and of three scientific papers; a two-days international conference on “ancient and modern populisms”, open to classicists, modern historians, and political scientists; a course of lectures on the ancient populism in the secondary schools; the creation of an internet site, intended both for scientific and educational use. The Popularitas project will historicize for the first time a much-discussed political phenomenon of our time and highlight similarities (and differences) with the ancient political practice. It will provide the tools for a diachronic assessment of modern populism, opening new research prospects. Its ambition is not only to be useful to the historians of the ancient world, but also to offer to political scientists and sociologist some fresh material and a new starting point for a proper understanding of the phenomenon.

Keywords: roman history,roman political factions,populism,populares,optimates,plebs,ancient democracy,greek and latin historiography
SCAlable LAttice Boltzmann Leaps to Exascale (SCALABLE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Innovation actions
Partnership: EuroHPC (Art-187)
Countries involved: Germany,Germany,Germany,France,France,France,Czechia
Call: Industrial software codes for extreme scale computing environments and applications (H2020-JTI-EuroHPC-2019-1, 2019)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 3444062.5
EU funding (EUR): 1415333.32
Participants: 10
Project status: SIGNED

In SCALABLE, eminent industrials and academic partners will team up to achieve the scaling to unprecedented performance, scalability, and energy efficiency of an industrial LBM-based computational fluid dynamics (CFD) software. Lattice Boltzmann methods (LBM) have already evolved to become trustworthy alternatives to conventional CFD. In several engineering applications they are shown to be roughly an order of magnitude faster than Navier-Stokes approaches in a fair comparison and in comparable scenarios. In the context of EuroHPC, LBM is especially well suited to exploit advanced supercomputer architectures through vectorization, accelerators, and massive parallelization. In the public domain research code waLBerla, superb performance and unlimited scalability has been demonstrated, reaching more than a trillion (10^12) lattice cells already on Petascale systems. waLBerla performance excels because of its uncompromising unique, architecture-specific automatic generation of optimized compute kernels, together with carefully designed parallel data structures. waLBerla, however, is not compliant with industrial applications due to lack of a geometry engine and user friendliness for non-HPC experts. On the other hand, the industrial CFD software LaBS already has such industrial capabilities at a proven high level of maturity, but it still has performance worthy of improvement. Therefore, SCALABLE will transfer the leading edge performance technology from waLBerla to LaBS, thus breaking the silos between the scientific computing world and physical flow modelling world to deliver improved efficiency and scalability for LaBS to be prepared for the upcoming European Exascale systems. The project outcomes will directly benefit to the European industry as confirmed by the active involvement of Renault & Airbus in the project and will additionally contribute to fundamental research.

Keywords: computation fluid dynamics,lattice boltzmann methods
Cell Plasticity in Metastatic Colorectal Cancer (PLASTICAN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Colorectal cancer (CRC) belongs to the most frequent tumor entities in both men and women. Although early detection and certain therapies have improved, the prognosis for patients with metastatic diseases is dismal and survival rates are below 10% at 5 years after diagnosis. Colorectal carcinogenesis is greatly dependent on the plasticity of both tumor cells as well as surrounding stromal cells within the tumor microenvironment. Among the latter, both T cells as well as mesenchymal cells substantially contribute to the survival prognosis. Importantly, mesenchymal cells are very heterogenous and various subtypes have been recently described in other tumor entities. Most likely these subtypes rather represent different activation states and have the capacity to interconvert, however, their precise functional role is unknown. Thus, a detailed mechanistic understanding about the cancer-stromal cross-talk as well as the stromal plasticity in CRC, particularly during late tumor stages and the relevance for metastasis development is lacking. Here we aim to perform well-defined hypothesis driven approaches to characterize the plasticity of both tumor and stromal cells and to develop innovative tools that will allow the functional analysis of distinct cell types in the stroma of primary tumors as well as in the pre-metastatic niche in the liver. This will be complemented by unbiased in vivo screens to identify novel pathways involved in plasticity of tumor epithelia and hepatocytes contributing to metastasis formation. Collectively, the combination of these comprehensive approaches that are based on sophisticated novel in vivo models as well as functional analysis of patient samples will ultimately aid the development of novel therapeutic strategies for late-stage CRC patients.
SUPERinductance for hardware-PROTECTED superconducting qubits (SuperProtected)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 2132595.0
EU funding (EUR): 2132595.0
Participants: 1
Project status: SIGNED

The quantum computer dream is driven by promises of unprecedented capabilities but is also facing a stark reality: quantum coherence is as powerful as it is difficult to protect. Quantum Error Correction (QEC) aims to extend coherence using redundancies but leads to solutions that are extremely resource-intensive: at present, protecting one bit of information requires at least ten thousand physical qubits. The main objective of this proposal is to engineer a new type of superconducting qubit, which will be intrinsically protected against de-coherence. Instead of matching the qubit states to the number of Cooper pairs or flux quanta of a given circuit, as is usually done, SuperProtected will exploit a completely new encoding scheme: quantum information will be stored as the parity of the number of Cooper pairs. This will be achieved by building a circuit component where charge transport occurs as pairs of Cooper pairs (4e-tunneling) while the standard single pair transport (2e-tunneling), or Josephson current, is reduced to zero. This new paradigm implies inductances with unprecedented value (10μH), also known as superinductances. The novel approach builds on two technological steps: a new high-kinetic inductance superconductor (InOx) and suspended silicon membranes. Improvement of the coherence time over current state-of-the-art is expected to be two orders of magnitude. The proposed qubits offer another major advantage: protected gates can be implemented using a simple modification of the architecture. The resulting protected qubit will extend the frontiers of the current knowledge in QEC and bring down the hardware requirements for a logical qubit by several orders of magnitude. Such a result would considerably change the quantum computing landscape.