Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The diagnostic potential of miRNAs for early diagnosis of Systemic Sclerosis (MIRASYS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-01-01
End date: 2017-06-30
Duration (months): 18.0
Total project cost (EUR): 149190.0
EU funding (EUR): 149190.0
Participants: 1
Project status: CLOSED

Systemic sclerosis (SSc) is a life-threatening autoimmune connective tissue disorder of unknown cause, characterised by fibrosis of the skin and internal organs. SSc affects approximately 160.000 patients worldwide and is associated with life-long burden of disease. Early detection of SSc is currently impossible as diagnosis is typically based on a combination of late-stage clinical symptoms. Current diagnostics, however, are based on late clinical manifestations. There is a need for actionable biomarkers for early-stage diagnosis and disease monitoring. Based on proprietary ERC research specific microRNA (miRNA) profiles were found that positively correlates with clinical progression and complications of SSc. Its expression was elevated in subjects who demonstrated symptoms that can precede SSc onset by years. These findings provide strong support for the prognostic and diagnostic properties of the miRNA panel in SSc. MIRASYS has been designed to accelerate the commercialisation of a panel of highly potent miRNAs that have breakthrough diagnostic potential in SSc. MIRASYS will be used to validate these findings by setting miRNA expression level boundaries for SSc development and to incorporate these in a diagnostic assay. MIRASYS will also assess the commercial feasibility of setting-up a dedicated spin-off company to commercialise the technology. The team has analysed the IP landscape for similar approaches for SSc and no prior art on the specific miRNAs was found. In the MIRASYS ERC PoC Grant, the team will further investigate the IP position and formulate a strong IP strategy including the steps towards full Freedom to Operate. The MIRASYS team consists of experienced science and business professionals. The team has developed several business models which need to be assessed thoroughly through in-depth market research. The results need to be consolidated into a strong business plan that will be presented to investors and strategic investors.

Keywords: biomarkers,medical diagnostics
Dynamics and transport of quantum matter --- exploring the interplay of topology, interactions and localization (QUANTMATT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany,Sweden
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-01-01
End date: 2021-03-31
Duration (months): 63.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1409785.37
Participants: 2
Project status: CLOSED

Quantum matter is condensed matter which properties are dominated by the quantum nature of its constituents. The two most fundamental properties of quantum mechanics are interference and entanglement. How do these properties, and their derivatives, show up in an experiment? And how does one control them? These are the fundamental questions addressed in this proposal. The study is divided into three main parts: many-body localization, topological insulator nanowires, and topological semimetals. Many-body localization is concerned with the interplay of interference and entanglement and is central to questions about quantum thermalization. I aim to understand experimental signatures of many-body localization as well as devising simulation schemes that allow us to conduct numerical experiments on many-body localization for larger system sizes than has been so far possible. The interplay of interference, topology and geometry is the central theme of the topic of topological insulator nanowires. I have in the past theoretically demonstrated the signatures of fundamental quantum phenomena in these systems, including perfectly transmitted mode and Majorana fermions. The major goal of this part of the project is to collaborate closely with experimental groups seeking to verify my past theories, by providing new and more detailed predictions for these systems. This requires to further understand experimental details, develop certain theoretical devices and simulation techniques based on them. The final part on topological semimetals is particularly timely in view of recent experimental realizations of Dirac semimetals and the impending realization of Weyl semimetals, which both can be roughly thought of as 3D analogs of graphene. I seek to understand their unique transport signatures and the interplay of disorder with 3D Dirac fermions. The three parts feed into and from each other both through unified concepts and common methodology.
Disagreements and Language Interpretation (DALI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-01-31
Duration (months): 65.0
Total project cost (EUR): 2499471.0
EU funding (EUR): 2197167.2
Participants: 2
Project status: CLOSED

Natural language expressions are supposed to be unambiguous in context. Yet more and more examples of use of expressions that are ambiguous in context, yet felicitous and rhetorically unmarked, are emerging. In my own work, I demonstrated that ambiguity in anaphoric reference is ubiquitous, through the study of disagreements in annotation, that I pioneered in CL. Since then, additional cases of ambiguous anaphoric reference have been found; and similar findings have been made for other aspects of language interpretation, including wordsense disambiguation, and even part-of-speech tagging. Using the Phrase Detectives Game-With-A-Purpose to collect massive amounts of judgments online, we found that up to 30% of anaphoric expressions in our data are ambiguous. These findings raise a serious challenge for computational linguistics (CL), as assumptions about the existence of a single interpretation in context are built in the dominant methodology, that depends on a reliably annotated gold standard. The goal of the proposed project is to tackle this fundamental issue of disagreements in interpretation by using computational methods for collecting and analysing such disagreements, some of which already exist but have never before been applied in linguistics on a large scale, some we will develop from scratch. Specifically, I propose to develop more advanced games-with-a-purpose to collect massive amounts of data about anaphora from people playing a game. I propose to use Bayesian models of annotation, widely used in epidemiology but not in linguistics, to analyse such data and identify genuine ambiguities; doing this for anaphora will require novel methods. Third, I propose to use these data to revisit current theories about anaphoric expressions that do not seem to cause infelicitousness when ambiguous. Finally, I propose to develop the first supervised approach to anaphora resolution that does not require a gold standard as a blueprint for other areas.

Keywords: semantics,discourse,anaphora resolution,coreference,ambiguity,corpus annotation,games with a purpose,crowdsourcing,bayesian models of annotation
Eco-efficient and Healthy Commercial Deep Fryer (FC-Unlimited)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-02-01
End date: 2019-11-30
Duration (months): 22.0
Total project cost (EUR): 1820896.25
EU funding (EUR): 1274627.38
Participants: 1
Project status: CLOSED

Deep fryers are essential for restaurant and food companies, however they: Are energy inefficient (<70%); Generate millions of litres of waste oil/year in Europe; Are not eco-friendly: Waste oil is harmful and is later found in rivers, lakes, etc; Produceburnt, greasy and unhealthy food if not used properly; Can produce toxic elements. Some of them are carcinogenic;Deteriorate oils, through the processes of oxidation and hydrogenation, leading to a loss of unsaturated fats and an increasein trans-fats; Cause labour hazards and are responsible for a significant number of serious accidents; Must be supervised bysemi-skilled, trained employees all the time to prevent food from burning and to prevent the danger of starting a fire or beinginjured; Have high costs of installation and maintenance: require exhaust ducts and fire protection systems. Also, theyshould have a specific insurance and receive periodic inspection and testing. QualityFry have developed a new enclosed and automated, commercial deep fat fryer, called FC-Unlimited, that has thefollowing unique selling points: Reduces the level of energy and oil required to prepare fried products; Healthier foodbecause it avoids the migration of oil into the final fried product; No need for trained or specialist staff; No need for fumeexhaust or fire safety certificates; Consistent, high quality of food; Can be installed anywhere; Modular and flexible set up tomeet end-client needs; Eliminates fire hazards and the risk of burns. The technology is currently at a prototype level and needs the support of the SME Inst. to scale up production to an industriallevel and demonstrate the product to future clients. We estimate that we will sell 526u in the first year of commercialisation, and reach up to 4,361 by 2023. The project has anet present value of 3.3M€ on the initial investment of 2M€ when considering a discount rate of 25%, with an IRR of 66%.Cumulative returns during the first 5 years reach 15.7M€.

Keywords: resource efficient,energy efficient,reduction of oil waste,high quality fried products,healthy food,safe at work,professional deep frier
Presidency event: Launch of the 2016 ESFRI Roadmap (KNAW-ESFRI)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Resilient Infrastructure
Action type: Coordination and support actions
Countries involved: Netherlands
Call: INFRA (H2020-Adhoc-2014-20, 2015)
Start date: 2016-01-01
End date: 2016-06-30
Duration (months): 6.0
Total project cost (EUR): 106312.5
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This proposal is about the organization of the launch event for the ESFRI Roadmap on 10 March 2016 in Amsterdam. This event will be organized by the Royal Netherlands Academy of Arts and Sciences (KNAW) in close cooperation with the Dutch Ministry of Science, Culture and Education (OCW), ESFRI and EC. This event is organized under the Dutch EU-presidency. During this event the European Strategy Forum on Research Infrastructures (ESFRI) will present its updated Roadmap 2016. The objectives of this event are amongst others: - -To present the ESFRI Roadmap 2016 publicly, - To discuss with major stakeholders the outcomes and conclusions of the ESFRI 2015-16 road-mapping exercise, - To reflect on the main challenges for implementation of research infrastructures, - To facilitate a quick start towards implementation for new research infrastructures included in the Roadmap, - To reflect among other themes on possible actions aiming at long-term sustainability of research infrastructures, - To prepare ground for the planning of 2018 ESFRI Roadmap update. ESFRI is a strategic instrument to develop the scientific integration of Europe and to strengthen its international outreach in the area of research infrastructures. The specific mission of ESFRI is to support a coherent and strategy-led approach to policy making on research infrastructures in Europe and to facilitate multilateral initiatives leading to a better use and development of research infrastructures at EU and international level.

Keywords: esfri roadmap research infrastructures knaw implementation
MULTI-PHYSICS METHODOLOGY FOR PHASE CHANGE DUE TO RAPIDLY DEPRESSURISED TWO-PHASE FLOWS (FireExtinction)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Spain,Spain
Call: Multi-Physics methodology for phase change due to rapidly depressurised two-phase flows (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 395937.5
EU funding (EUR): 395937.5
Participants: 3
Project status: CLOSED

A multi-physics methodology is proposed to couple CFD calculations with models for phase change of rapidly depressurised mist of a fire suppression system. The methodology combines existing models with newly developed ideas with considers the coupling between large and small scales. The new models aim to describe the penetration of a two-phase flow and phase transitions into the confounding space and will be implemented as a user defined function in a tool chain and coupled with the nearfield CFD calculation. Both, a Lagragian and a Eulerian formulation will be followed using existing commercial tools and “in-house” multiphase solvers. Finally, one experiment is proposed to validate the numerical results in one relevant case.

Keywords: fire supression,multi physics,phase change,thermodynamic
Transparent and Flexible Li-Organic 3D Thin-Film Microbattery (TransFlexBattery)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Finland
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

In this Proof-of-Concept project we will demonstrate the practical feasibility of a fundamentally novel transparent and flexible Li-organic thin-film microbattery. The strong basis for the project is the new hybrid Li-organic electrode materials discovered in the PI's ERC Advanced Grant Project “Molecular-Layer-Engineered Inorganic-Organic Hybrid Materials (LAYERENG-HYBMAT)”. These hybrid thin-film materials are fabricated by the combined atomic/molecular layer deposition (ALD/MLD) technique which uniquely allows for fabrication of highly conformal thin-film coatings on various flexible, sensitive, functional and/or nanostructured surfaces. Within this PoC project we will (1) design and construct an actual optimized all-ALD/MLD Li-organic battery cell, (2) confirm its optical transparency and mechanical flexibility as expected, (3) identify the most potential applications for this new type of 3D thin-film microbattery, (4) assess its real-life business opportunities, and (5) build up a network of academic and industrial collaborators for the further advancement of the novel technology.

Keywords: lithium ion battery,solid state thin film microbattery,flexible and transparent organic battery,inorganic organic hybrid materials,atemic layer deposition,molecular layer deposition
Quantum simulation of strong interaction of light and matter (QuSLAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2020-09-30
Duration (months): 18.0
Total project cost (EUR): 131104.8
EU funding (EUR): 131104.8
Participants: 1
Project status: CLOSED

Quantum optics describes the emission and absorption of radiation by quantum systems. The most interesting effects of the coupling between quantum emitters and their environment (a bath) appear when this coupling becomes strong. If multiple quantum emitters are coupled strongly to the same bath, the emitters themselves interact strongly via the bath, opening the way to engineered many-body quantum systems with interesting radiative properties, such as directional emission, chirality, and subradiance. However, fundamental and technical issues limit the coupling strength achievable with state-of-the-art experimental platforms: emitters placed in microcavities or coupled to nanophotonic structures. To circumvent these issues, the applicant proposes to realize an analog quantum simulation of quantum emitters strongly coupled to baths with engineered band structures in one and two dimensions. In this quantum simulation all relevant parameters will be arbitrarily tunable allowing the realization of all system regimes, including the strong coupling regime. This tunability will be achieved by replacing the quantum emitter with an artificial two-level quantum system. Ultracold strontium atoms trapped in optical lattices will be used for this purpose. The implemented quantum simulator will be used to realize and directly image bound states in one and two dimensions that could enable strong long-range atom-atom interactions. Furthermore, by tailoring the emission direction and dynamics of multiple emitters in 1D and 2D, unprecedentedly long-lived subradiant states will be engineered, with applications in precision measurements, metrology, and quantum computing. This project will also open up the possibility of going beyond the physics of photonic baths and engineering both noninteracting and strongly-interacting baths, consisting of either bosonic or fermionic particles, that have no analog in quantum optics.

Keywords: quantum simulators,optical lattices,subradiant states,quantum gas microscope,single site imaging,optical clocks
Network of summer academies for the improvement of entrepreneurship in innovative sectors (CREA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Estonia,Italy,Italy,Germany,Greece,Slovenia,Netherlands,United Kingdom
Call: Innovation and Entrepreneurship Support (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2017-04-30
Duration (months): 28.0
Total project cost (EUR): 1559422.5
EU funding (EUR): 1468896.37
Participants: 10
Project status: CLOSED

CREA aims to promote ICT development and creativity as new drivers able to produce specific structural changes and arrangements in the European entrepreneurial base, to influence the future paths of social change and innovation to a large extent. CREA project wants to validate a new European Model of Summer Academy for students who wants to develop business ideas focus on creativity and ICT and able to explore innovation in advanced fields: new products for new markets, social innovation, meaning drive innovation in old sectors, service innovation, technology driven innovation etc. CREA will test 2 edition of Summer Academy simultaneously organized in 6 European Cities (Milan, Stuttgart, Ljubljana, Newcastle, Tallin, Utrecht), which will end with an international event (CREA ICT Business Idea Contest) for the presentation of results to international investors and the awarding of a prize. The project includes training courses, mentoring activities and the incubation program for start up companies that will be able to use the opportunities of ICT and Creativity to propose new business model with a European vision. The general objectives of CREA project are: - To create European wide system of Summer Academies for university and last year high school students entirely focused on ICT entrepreneurship; - To create a model of Summer Academy action oriented with a strong focus on ICT and entrepreneurial skills development and a rich offer of mentoring, support for business planning, matchmaking opportunities and generation of ICT related business idea; - To stimulate the development of new start up business ideas boosting on ICT and creativity; - To complement and extend similar existing Summer Academy program while strongly focusing on ICT and creativity entrepreneurship; - To organize and promote ICT Business Idea Contests.

Keywords: creativity,cross fertilisation,business idea development,business idea contest
Predictive Memory Systems Across the Human Lifespan (PIVOTAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany,United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-07-31
Duration (months): 66.0
Total project cost (EUR): 1416934.0
EU funding (EUR): 1330126.5
Participants: 2
Project status: SIGNED

As neuroscientific findings on brain functions accumulate, it is increasingly important to derive a set of overarching general principles about how the human brain works. For this, the predictive coding framework emerges as a promising route, with the notion that the brain operates as a prediction machine; internal models in the brain predict future states against which incoming information of new experience is compared. This new conceptual framework leads to two essential empirical questions that PIVOTAL will tackle: (1) What is the nature of the internal models on which predictions are generated and how do our actual experiences shape them? (2) How do prediction processes play out in human brains that are inherently diverse due to changes such as those caused by maturation and senescence. Addressing these issues is important for advancing our basic understanding of the neurocognitive architectures that enable the brain to perform adaptively in our environment, with predictive processing as a fundamental operation. PIVOTAL will integrate three separate strands of cognitive neuroscience research on predictive coding, memory systems, and lifespan development. By using functional magnetic resonance imaging (fMRI) in experimental research designs, we aim to unravel the cognitive and neural mechanisms that underlie predictive processing based on individuals’ memory of prior experience (episodic memory) and well-learned knowledge about the world (semantic memory). These mechanisms will be systematically examined in samples of children, younger adults, and older adults, who differ from each other in important ways due to divergence in developmental orientation (progression vs. conservation) and neurocognitive landscape (structural and functional integrity of memory neural circuits). By explicating a more dynamic version of the predictive brain principle, we can start addressing issues related to the emergence of disorders at particular time windows in life.

Keywords: predictive coding,memory systems,human life span development,cognitive neuroscience