Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Targeting integrin signaling in tumour-associated macrophages to combat cancer progression and resistance (MacrophInt)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-11-01
End date: 2021-10-31
Duration (months): 24.0
Total project cost (EUR): 116953.92
EU funding (EUR): 116953.92
Participants: 1
Project status: CLOSED

Cancer is the most common cause of death and morbidity in Europe. New therapeutic targets to combat this disease are critical. Across many solid cancers, poor prognosis largely correlates with the infiltration of tumour-associated macrophages (TAMs). TAMs enhance tumour progression and complicate various anticancer therapies. Although macrophages primarily employ amoeboid migration for homeostasis and immune functions, TAMs primarily utilize mesenchymal migration. Experiments in mice revealed that blockade of TAM mesenchymal migration lowers infiltration within tumours and reduces tumour growth. Targeting this distinctive feature has the potential to limit TAM recruitment in tumours and halt disease progression, while preserving healthy macrophage functions. The mesenchymal migratory mode involves podosomes and is characterized by integrin-mediated adherence to the surrounding extracellular matrix (ECM), and the requirement of ECM proteolysis. In sharp contrast, amoeboid migration is independent of podosomes and integrins. We will investigate and evaluate the potential of targeting integrin signaling as a new strategy to manipulate TAM infiltration into tumours. Elegant knock-in and knockout mouse models will be used to establish the key regulators of integrin signaling in TAM mesenchymal migration. This novel paradigm will be extended to TAM migration in human breast tumour specimens. We will also provide new insights at the subcellular level by exploring the roles of integrin signaling in the formation and function of podosomes. Our study endeavours to identify novel and unanticipated avenues for blockade of TAM mesenchymal migration and tumour infiltration to synergize with current combination therapies that simultaneously target both pro-tumour stromal cells and cancer cells. Targeting mesenchymal migration in macrophages could have far-reaching implications beyond cancer in other disease contexts that involve macrophages including chronic inflammation.

Keywords: tumour associated macrophages,migration,tumour infiltration,solid tumours,adhesion,podosomes,integrin,talin1,inside out signaling
Zero Emission Robot-Boat for Coastal and Inland Water Monitoring (ZEBCOM)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Bulgaria
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project aims to develop an eco-innovative product: a zero emission autonomous (unmanned) robot-boat system intended for use as a monitoring station for quality & quantity of surface waters. The proposed innovative product (system) aims to contribute to solving two important issues: -The (unprecedented) need of high quality, real-time information/data on water environment related primarily to the Increasing climate change uncertainty, and to protection of the environment -The need of low-carbon, low-cost, effective vessels operating in inland and coastal water The positioning of the present business innovation project can be estimated as being at “TRL7 – system prototype demonstration in operational environment”. The robot-boat system is intended to be operated as an unmanned apparatus; having onboard computer and a large-range radio-telemetry system for real-time transfer of data for desktop and web-applications; with a large carrying capacity and special shape, to carry onboard various measurement equipment ; incorporating a number of innovative solutions. Main objective of project Phase 1 is the development of a Feasibility study including a business plan. A comprehensive analysis of basic Technological factors, Economics, Marketing and Financial study, Legal requirements, Operational conditions will be carried out. The use of the system as an autonomous monitoring unit can provide low-cost, efficient and routine monitoring of the aquatic environment, this way providing significant impact on EU water sector. Reliable data from such observations are of crucial importance to understanding and adaptation to climate change, as well as to respond to unprecedented burden on water resources, needed not only for safe drinking water, but also to support agriculture, energy, transportation, manufacturing, and civil infrastructure. It can also help coastal and catchment communities to adapt to climate change, and react to flood hazards and environmental threats.

Keywords: water environmental monitoring technologies,autonomous robot boat,eco innovation
Spin-Orbit Torque in 2D van der Waals Heterostructures (SOT-2DvdW)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-18
End date: 2020-07-17
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

This Marie-Curie proposal aims to study the mechanisms governing spin-orbit torque in 2D ferromagnetic materials attached to topological insulators. It also proposes a new method to detect the magnetization dynamics of the 2D ferromagnet by using photoluminescence. This is done by measuring the valley splitting induced by exchange proximity effect on a transition metal dichalcogenide (TMD) semiconductor monolayer deposited, or grown, on top of the 2D ferromagnet. I propose first to study the different heterostructures involved, namely 2D ferromagnet/TMD monolayer and 2D ferromagnet/topological insulator, using density functional theory (DFT) in order to get some insight on the electronic structures at the interface between these materials and the different physical phenomena that may take place at these interfaces. This DFT calculations will also help to detect those pairs 2D ferromagnet/TMD monolayer leading to a higher valley splitting which translates into a stronger optical response and clearer peak splitting in the photoluminescence spectra. Second, I propose to use Hamiltonians based on these DFT calculations and non-equilibrium Green’s function formalism to study the torques induced in the 2D ferromagnet after charge injection into the topological insulator. For this, I plan to implement the calculation of field-like and damping-like torques within a previously developed NEGF code. With this proposal, I expect to provide society and researchers with a new methodology which will help to develop new storage devices using 2D materials and other van der Waals materials, which are at the forefront of next generation nano-devices.

Keywords: 2d materials,spin obitronics,non equilibrium transport,topological insulators
Keys to evolutionary success: untangling drivers of hyperdiversification (HYPERDIVERSE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1949788.0
EU funding (EUR): 1949788.0
Participants: 1
Project status: SIGNED

Explaining why some taxa are more diversified than their closest relatives remains one of the major challenges in evolutionary biology. However, much of Earth’s biodiversity is concentrated in few diverse non-vertebrate animal lineages, whose analysis of diversification dynamics is hampered by the lack of empirical data. The NEOME project will focus on one hyperdiverse and poorly-known taxon of molluscs, the marine predators Neogastropoda. Their high species diversity (>15,000 species), largely undescribed, and the key innovations they evolved, linked to their feeding habits and dispersal abilities, make them a perfect model system to test hypotheses related to the diversification of hyperdiverse taxa. The first objective of the project will be to reconstruct a robust, precise and complete phylogeny of the group by using cutting-edge omic technologies. The second goal will be to test correlations between two traits – the exogenome diversity as proxy of feeding habits, and the type of larval development as a proxy of dispersal capabilities, which are keys for understanding diversification dynamics, using genomic, transcriptomic and proteomic approaches. The same data will also be used to fulfil the last objective: identifying the genetic determinants of the two traits, the molecular mechanisms at the origin of their diversity, and the processes by which these traits interact with the environment to mediate the diversification of the neogastropods. The major breakthrough of the project will thus rely on the joint analysis of the correlation between traits and diversification and of the causal factors at the origin of this correlation. Furthermore, the project will also impact other fields of research, with the production of unique data on many culturally, economically and scientifically important species, including the first complete genomes for the group, and the characterization of numerous compounds potentially promising in human therapeutics and biotechnologies.

Keywords: evolutionary systematics,population genomics,exogenomic,comparative transcriptomics and proteomics
Peer to Peer Smart Energy Distribution Networks (P2P-SmartTest) (P2P-SmarTest)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Spain,Spain,Spain,Spain,Spain,Belgium,Finland,United Kingdom,United Kingdom
Call: Distribution grid and retail market (H2020-LCE-2014-3, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 3866215.0
EU funding (EUR): 3496141.5
Participants: 9
Project status: CLOSED

P2P-SmartTest project investigates and demonstrates a smarter electricity distribution system integrated with advanced ICT, regional markets and innovative business models. It will employ Peer-to-Peer (P2P) approaches to ensure the integration of demand side flexibility and the optimum operation of DER and other resources within the network while maintaining second-to-second power balance and the quality and security of the supply. The proposed project will built upon extensive experience of the consortium on Information and Communications Technologies (ICT), especially ICT for the Energy Sector, Smart Grids including Distributed Energy Resources (DER) integration, MicroGrids, CELLs, Virtual Power Plants etc., power system economics, electricity markets and business models. The project comprises of 7 work packages (WP), of which 5 are technical WPs. Apart from project management (WP1) and dissemination and exploitation (WP7) the P2P-SmartTest project defines and demonstrates the suitable business models (WP2) for peer-to-peer based distributed smart energy grids, quantify the value from significantly increased system interaction and integration, and assess the required development in ICT and power networks in conjunction with commercial and regulatory frameworks to enable P2P trading realising its full potential. WP3 shall develop and demonstrate the distributed wireless ICT solutions capable of offloading the required traffic of different applications of energy trading, network optimization, AMR data and real-time network control to name a few. In WP4 the optimization mechanisms of energy flows in P2P context shall be defined, as well as market design solutions. To properly operate distributed network, WP5 shall integrate the necessary network operation functions for resilient distribution system operation. The results of WPs 2-5 will be integrated to demonstration and validation environment in WP 6 to provide real-life results of distributed energy system designs.

Keywords: peer to peer,ict architecture,smart grid,micro grid,energy market,system operation,demand response
Lab to Fab development of air decontamination system for protecting health practitioners against COVID19 (CleanAir)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Action type: Innovation actions
Countries involved: Austria,Austria,Germany,Italy,Israel
Call: Medical technologies, Digital tools and Artificial Intelligence (AI) analytics to improve surveillance and care at high Technology Readiness Levels (TRL) (H2020-SC1-PHE-CORONAVIRUS-2020-2-CNECT, 2020)
Start date: 2020-11-01
End date: 2023-01-31
Duration (months): 27.0
Total project cost (EUR): 3198750.0
EU funding (EUR): 2303250.0
Participants: 9
Project status: SIGNED

The CleanAir project relates to the application of an innovative and novel geometrically extended electrode design to be integrated in air ionizers. This innovative electrode design has already been pre-tested successfully for efficient electrostatic disinfection and particle removal from air. Contrary to other air ionizers available on the market it does not produce any harmful substances such as ozone or NOx because corona discharges will not occur. As a further innovative step, the electrode can be manufactured in different and much larger sizes and various 3D geometries to make them suitable to different needs from the medical end consumers for mounting them in examination and treatment rooms. The final product will be easily adaptable to be used efficiently in rooms of different sizes and heights. The aim of the CleanAir project is to develop this technology to a market-ready and CE mark certified device for series production for protecting health practitioners and their patients against COVID-19 infections. Market ready devices for three application areas will be preferentially developed in the project: for dental treatment rooms, for medical doctors offices and for patients rooms in a hospital. The project will prepare all required documentation, marketing information, customer portfolio and a sales and detailed business plan for being ready after the end of the project to start the series production and commercialization phase.

Keywords: health,codid19,coronavirus,innovation,healthcare,medical,air decontamination,air purification,clean air,air ionization
COVID-19 ICU-CARE – A ground-breaking ICU bed-side COVID-19 trachea flushing system that can cut healthcare costs and reduce COVID-19 spread between ICU patients and staff (COVID-19 ICU-CARE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-08-01
End date: 2021-07-31
Duration (months): 12.0
Total project cost (EUR): 1719017.5
EU funding (EUR): 1196749.0
Participants: 1
Project status: CLOSED

When the severely ill COVID-19 patients are admitted to the Intensive Care Unit (ICU) for respiratory support (breathing with the support of a mechanical ventilator), it is crucial that the upper airways of these patients are being suctioned many times daily to remove secretion and mucus, in order to prevent lung infections. If not removed efficiently, there is >50% likelihood of mortality. Unfortunately, the suctioning techniques today have 2 major limitations 1) it cant remove secretions efficiently and thereby preventing lung infections and 2) it induces a very high risk of COVID-19 spread amongst ICU patients and staff, as secretion is suctioned outside the patients body. AW Technologies aims to solve these problems with TrachFlush – a patented suctioning assist system. As an add-on to standard mechanical ventilation systems used in the ICU, TrachFlush automatically flushes ALL secretion out of the airways and has already shown to cut cost and to reduce contamination in a small feasibility study on general ICU patients. The aim of this project is to take TrachFlush to market and battle the COVID-19 outbreak. In collaboration with experts from 5 leading hospitals from Denmark, Italy, Holland and Spain, this COVID-19 ICU-CARE project concerns a large-scale clinical study to reach TRL 8 and aims to demonstrate: 1) a 90% efficient secretion removal and implicit reduction in lung infections, 2) a 90% reduction in ICU nurse workload and, 3) elimination of any contamination between patients and staff – on COVID-19 patients! When we reach these goals, we can help EU battle the COVID-19 outbreak. The business opportunity is huge. Our market is €3,6Bn and will reach €4,5Bn by 2025. Via a recently signed distribution agreement with an ICU ventilator manufacturer, we aim for rapid market penetration and a market share of 5,3%, a turnover of €100M, an EBITDA of €57M and additional employment of 22 people by 2025. We foresee a total budget of €1.7M for this project

Keywords: covid 19,intensive care unit,icu mechanical ventilation,medical devices
Bridging the Early Diagnosis and Treatment Gap of Brain Diseases via Smart, Connected, Proactive and Evidence-based Technological Interventions (ALAMEDA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Spain,Italy,Cyprus,Norway,Greece,Romania,Greece,Greece,Greece,Luxembourg,United Kingdom
Call: Personalised early risk prediction, prevention and intervention based on Artificial Intelligence and Big Data technologies (H2020-SC1-DTH-2020-1, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 6053812.5
EU funding (EUR): 6053812.0
Participants: 16
Project status: SIGNED

Direct costs of brain disorders make up for 60% of the total costs – which EBC estimated at 800 bln€/year in Europe. At European level, this health budget far exceeds that of cardiovascular diseases, brain diseases and diabetes together. ALAMEDA will research, develop and exploit the next generation of personalized AI healthcare support systems that improve the rehabilitation treatment of Parkinson’s, Multiple Sclerosis, and Stroke (PMSS) patients. Stemming from very specific clinical use cases, ALAMEDA will develop user-friendly solutions that will be designed and evaluated on the principles of value-based health. The consortium brings together established medical research teams, AI researchers, medical software vendors and healthcare market experts to demonstrate AI-based personalised prediction, prevention, and intervention approach in three (3) real world pilots. Liaisons have been established with projects MULTI-ACT and IDEA-FAST and the carefully structured workplan, embodies an integrated and harmonized approach with active patients’ engagement towards meeting the ALAMEDA objectives and delivering market-relevant outcomes of significant exploitation potential.

Keywords: parkinson s,multiple sclerosis,stroke,retrospective data sources,brain diseases,machine learning,value based health,shared decision model,digital transformation,deep learning
Meiotic crossing-over: from spatial distribution to in situ chromosomal architecture (CrossOver)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 1999180.0
EU funding (EUR): 1999180.0
Participants: 1
Project status: SIGNED

To haploidise their genome, sexually reproducing organisms employ a specialised cell division program – meiosis – which consists of one round of DNA replication followed by two consecutive rounds of chromosome segregation: meiosis I and II. While meiosis II resembles mitosis, the ability of cells to segregate homologous chromosomes entails several specialised events. In most organisms, physical linkage and subsequent disjunction of maternal and paternal chromosomes require homologous recombination and crossing-over. As observed over a century ago, crossovers occur at different chromosomal positions in different meiotic nuclei – however, the incidence of a crossover in a given location reduces the probability of a neighbouring crossover event. As a result, crossovers tend to be widely and evenly spaced along chromosomes, a phenomenon termed crossover interference. Work in the last 30 years has led to remarkable progress in the delineation of the sequence of molecular events that lead to crossing-over. However, how cells spatially regulate the deployment and assembly of molecular determinants to accomplish crossover patterning remains largely unknown. Here, I propose to tackle this fundamental question through the development of two novel approaches tailored to explore central aspects of meiotic recombination with unprecedented resolution: i) to understand how chromosomal context shapes crossing-over, we will develop novel methodology (HJmap) to achieve genome-wide mapping of Holliday junctions: central recombination intermediates which mark future crossover sites. ii) to explore how local chromosomal features influence crossing-over, we will visualise the architecture of crossover-designated recombination intermediates in situ, and in 3D, using electron cryotomography. By understanding how cells implement genetic exchange through crossing-over we will shed light on the molecular basis of heredity: the passing of traits from parents to their offspring.

Keywords: meiosis,homologous recombination,nucleases,dna repair,chromosomes