Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Elucidating the Mechanisms of Insect’s Chemical Taste to Understand Specific Host-Plant Selection (ChemoSense)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-12-01
End date: 2019-01-28
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The sense of taste enables an animal to decide what it eats and drinks. Insects are able to discriminate among soluble chemicals via their gustatory receptors (GRs) in order to accept or reject a certain food plant or initiate mating and oviposition. Despite their essential role in the insect’s overall food intake, survival and reproductive success, relatively little is known about insect GRs, especially in beetles. This is surprising given their importance as agricultural and forestry pests, their global distribution and huge species number as herbivorous insects. I aim to identify and characterise GRs that mediate host plant selection in a specialist poplar leaf beetle, Chrysomela populi. These beetles feed on economically important poplar trees and damage timber plantations worldwide. It is hypothesised that the phenolic glucoside salicin in poplar is a major taste stimulant for C. populi and enhances feeding activity. However, it is unknown how salicin or, alternatively, other taste stimulants are detected by, and interact with specific GRs in C. populi to elicit feeding behaviour. I will elucidate these mechanisms by (i) identification of candidate genes encoding GRs in C. populi via tissue specific transcriptome sequencing and transcript visualisation via RNA-FISH, (ii) knock-down of single GR genes via RNAi to test the feeding behaviour of RNAi-silenced beetles, and (iii) test whether any of the taste stimulants from poplar function as in vivo and in vitro ligand for specific C. populi GRs by tissue-specific electrophysiological recordings and heterologous expression, respectively. These results will shed new light on the question how GRs function as regulators for herbivorous beetles to select and consume specific plants, which will significantly advance our knowledge in understanding host plant selection. As poplar leaf beetles are important pests, the results may also pave the way for timely development of sustainable pest management in forestry.

Keywords: chemosensation,gustatory receptors,insect herbivory,specialists,insect plant interactions
Diplomatic Face-Work - between confidential negotiations and public display (DIPLOFACE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Denmark,United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2023-04-30
Duration (months): 85.0
Total project cost (EUR): 1493062.0
EU funding (EUR): 1414252.0
Participants: 2
Project status: CLOSED

The rise of social media, coupled with intensifying demands for more transparency and democracy in world politics, brings new challenges to international diplomacy. State leaders and diplomats continue to react to traditional media, but now also attempt to present themselves proactively through tweets, public diplomacy and nation branding. These efforts often take place simultaneously and sometimes interfere directly with closed-door negotiations and its culture of restraint and secrecy. Yet the relationship between confidential diplomacy and public representation remains understudied. DIPLOFACE will develop a sociologically and anthropologically informed approach to studying how state leaders and diplomats manage their nation’s ‘faces’ in the information age. The project will explore the relationship and tensions between confidential diplomatic negotiations and publicly displayed interventions in various media, applying the micro-sociological concept of ‘face-work’. DIPLOFACE will analyse the complex interactional dynamics that shape the diplomatic techniques and strategies used to convey a nation’s ‘face’ or ‘image of self’. Such face-work is increasingly important for national leaders and diplomats who perform simultaneously on the ‘back-stage’ and the ‘front-stage’ of international relations. DIPLOFACE will identify, theorize and analyse the repertoire of face-saving, face-honouring and face-threatening practices that are employed in confidential negotiations and in public. DIPLOFACE advances our theoretical understanding of diplomacy in the 21st century significantly beyond existing International Relations and diplomatic theory. Combining participant observation, interviews and media analysis, DIPLOFACE will generate important new knowledge about the relationship between public and confidential multilateral negotiation, how state leaders and diplomats handle new media, and the role of face-saving and face-threatening strategies in international relations.
PROOF OF AUGMENTED SAFETY CONDITIONS IN ADVANCED LIQUID-METAL-COOLED SYSTEMS (PASCAL)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Nuclear safety
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Italy,Italy,Italy,Lithuania,Sweden,Sweden,Romania,Switzerland,Belgium,Belgium,Netherlands,Netherlands
Call: Safety Research and Innovation for advanced nuclear systems (NFRP-2019-2020, 2019)
Start date: 2020-11-01
End date: 2024-10-31
Duration (months): 48.0
Total project cost (EUR): 4610189.08
EU funding (EUR): 3799238.0
Participants: 16
Project status: SIGNED

The PASCAL project is devoted at significantly contribute to the advancement of the safety research on innovative heavy liquid metal cooled reactors, with the ambition to generate evidence that is ready-for-use in the discussions between the ALFRED and MYRRHA designers and the respective safety authorities in the pre-licensing phase. The goals of PASCAL also set an ambition of relevance and quality to the results, which is reflected in structuring and organizing the proposal. Relevant experiments in representative conditions are planned, and - wherever applicable - accompaigned by simulations with the objective of extending their domain of validation and reducing uncertainties. The selected activities all address the main reference: supporting the justification of resilience to severe accident conditions, aiming to demonstrate the claim that no off-site emergency measures are needed for an HLM-cooled system. Finally, the project will strengthen the longstanding collaborations among European organizations, and will strongly support the education and training of a new generation of experts, to secure safety culture is preserved.

Keywords: advanced reactors,lead fast reactors,safety,experimental validation
Demography, Cultural change, and the Diffusion of Rice and Millet during the Jomon-Yayoi transition in prehistoric Japan (ENCOUNTER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-04-01
End date: 2024-11-30
Duration (months): 68.0
Total project cost (EUR): 1499095.0
EU funding (EUR): 1083431.0
Participants: 2
Project status: SIGNED

Human history is punctuated by episodes of large-scale diffusion of new ideas and people that lead to era-defining transitions in past societies. Investigating what promotes these events, how societies react to these, and what are their long-term consequences is a key to understand the fundamental drivers of cultural change. ENCOUNTER will push forward this research agenda by investigating the Jomon-Yayoi transition, a demic and cultural diffusion event that led the predominantly hunting, gathering, and fishing-based communities of the Japanese islands to adopt rice and millet farming during the 1st millennium BC. The continental migrants who triggered this transition event did not bring just a new economy, but also new technology and culture, deeply impacting the indigenous society. The transition was however not uniform, as different regions responded to the new culture in different ways. Some immediately adopted the new cultural repertoire to its full extent, others embraced only certain elements, and still others resisted for over 1,000 years, generating cultural, linguistic and genetic clines that are still tangible today. ENCOUNTER will investigate this pivotal moment in Japanese prehistory, seeking to determine why the indigenous inhabitants responded so differently to the arrival of the new culture. It will examine the dynamics of this transition by: synthesising one of the richest archaeological records available in the world; combining new and old lines of evidence across different disciplines, including organic chemistry, palynology, and material culture studies; and developing a suite of computational techniques to reconstruct patterns of demographic change and cultural diffusion. It will question the existing narrative that farming is inevitable and instead put new emphasis on the incumbent hunter-gatherer populations to understand their motivations to change subsistence strategies with respect to their environment settings and cultural affinities.
Weed control in row crop farming through natural biocementation (Dust BioSolutions)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Dust BioSolutions is a Munich-based start-up company that aims to become the “no.1 address for biological binders” worldwide. Its mission is to develop, produce, and sell products that solidify permeable materials to improve sustainability, profitability and innovation of established industries with the help of biotechnology. Dust BioSolutions has developed a proprietary technology platform and patented applications based on a bio-geochemical process called microbiologically induced calcium carbonate precipitation. In 2016, Dust BioSolutions decided to expand its product range on weed prevention and management in the agriculture sector. BioWeedControl, which comes either in a solid (powder) or in a liquid form has been successfully developed to a TRL6. Dust BioSolutions has collaboration agreements for final product development with different industry partners and currently more than 25 large scale field tests ongoing. Results show that BioWeedControl has comparable performance to most commonly used products, but can also leverage on additional functionalities. Competition from weeds is one of the major factors reducing crop yield and farmers’ income. This issue is worsened by the growing number of weeds becoming herbicide-resistant. BioWeedControl wants to overcome many disadvantages of currently available products. Dust BioSolutions expects BioWeedControl to become one of the best alternative solutions to weed prevention in the agriculture sector.

Keywords: weed control,biological binders,biotechnology,biobased industry,microbiologically induced calcium carbonate precipitation micp,biocementation,biomineralization,agriculture
Non invasive Cell Based Liquid Biopsy Platform for Bladder Cancer (OneRNA4Bladder)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Denmark
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-12-01
End date: 2020-11-30
Duration (months): 36.0
Total project cost (EUR): 3713994.25
EU funding (EUR): 3713994.25
Participants: 1
Project status: CLOSED

OneRNA4Bladder aims to save lives and reduce cost of care for bladder cancer treatment – the most expensive type of cancer to treat due to expensive diagnostic procedures and ineffective drugs leading to a recurrence rate of 70%. Implementing the OneRNA4Bladder system for bladder cancer recurrence detection could cut the cost of managing bladder cancer in half, resulting in savings of more than €800 million/year in Europe The key project technology is a patented Urine Cancer Cell Filtration Device (UCCFD) that enables the selection of tumor cells from a simple urine sample. The UCCFD was developed and validated in a small prospective clinical study by the Danish Cancer Society and in-licensed by Genomic Expression Aps (GEx). In OneRNA4Bladder, GEx aims at the clinical validation of the UCCFD – in combination with DNA biomarkers – for the detection of bladder cancer recurrence. Furthermore, the UCCFD can – in combination with GEx’s proprietary OneRNA™ platform, which links RNA's to drugs that can provide a more effective treatment – be applied as a liquid biopsy platform to monitor the disease response to treatment without invasive biopsies or cystoscopies. In OneRNA4Bladder, we will also clinically validate the UCCFD technology together with OneRNA™ as a liquid biopsy platform. OneRNA4Bladder is an opportunity for GEx to enter the world-wide bladder cancer diagnostic market. The accomplishment of the project objectives will represent a significant business opportunity for the SME, with expected sales of over €165 million within 5 years of launch.

Keywords: bladder cancer,recurrence,urine cancer cell filtration device,non invasive,cost,reduction
Post ERuption Incision of Landscapes (PERIL) (PERIL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Although more than 11% of the world’s population lives close enough to an active volcano to be at risk from a potentially hazardous eruption, little research has been done to understand the long-term and often devastating consequences eruptions can have on the local landscape. After a major volcanic eruption, the surrounding landscape is significantly destabilised by the mass of volcanic material deposited on it, which can dam rivers, destroy vegetation, and lie precariously on steep slopes. For example, the 1991 eruption of Mount Pinatubo in the Philippines left more than 700 people dead, but only ~50% lost their lives during the eruption itself. The rest were killed in the following months by mudflows and landslides that displaced >150,000 people. There are many other examples where such secondary hazards have proven just as deadly and disruptive as the initial volcanic eruption, and yet little research has been done into how post-eruptive landscapes evolve. Addressing this issue requires a cross-disciplinary approach that combines the fields of volcanology and geomorphology. The specific goal of this research is to create an accessible, user friendly computer model that can predict patterns and rates of landscape response after a volcanic event. The model will be refined from observations of how certain natural volcanic landscapes have evolved after recent eruptions. With this new model, government agencies, non-profit organisations, local businesses, and private citizens will have the capability to predict and mitigate post-eruption hazards in vulnerable communities around the world.

Keywords: volcanic geomorphology,landscape evolution modelling,secondary volcanic hazards
Disruptive GPCR Lead Discovery Platform Delivering New and Safer Therapeutics (PICARD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

InterAx Biotech, a Swiss company and spin-off from the ETH Zürich and the Paul Scherrer Institute has built PICARD, a unique drug discovery platform for the identification of drug candidates with improved efficacy and reduced side effects for the largest class of human receptors: The G-Protein Coupled Receptors (GPCRs). These receptors play a central role in many vital biological processes and they are implicated in a large variety of human diseases. Due to their complex nature and mechanisms that lead to the disease state, only 60 out of 375 pharmacologically relevant GPCRs have been successfully targeted by drugs, leaving >80% GPCRs without therapeutics. Bringing a drug to the market requires an investment of up to €2.2B; out of 5000 compounds only 5 will make it to the clinical trial phase and 9 out of 10 compounds fail during costly clinical trials. This inflates the price of the drugs that reach the patients, making the society paying for inefficiencies of pharmaceutical R&D. PICARD will enable better and earlier detection of safety and efficacy profiles of GPCR-targeting drugs by increasing quality and reducing costs and time-to-market of new therapeutics. The novelty of our discovery platform lies on the combination of our screening to find novel compounds, signalling Assays that cover the most common GPCR activation aspects and our Systems Biology approach leading to highly efficient and fast delivery of functional-selective compounds. We offer custom-designed PICARD services to pharmaceutical and biotech companies that are outsourcing key stages of their drug discovery process lowering risks and greatly reducing R&D costs. The revenue stream is generated both from fee per service and from long-term drug discovery partnerships with upfront and milestone payments. We estimate reaching break-even 2 years after commercialization with 45 FTE and achieving a ROI of 4.5.

Keywords: drug discovery,drug development,biotech,pharma,gpcr
A BIONIC INVISIBLE PANCREAS TO FORGET DIABETES (FORGETDIABETES)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Germany,Italy,Italy,Norway,France
Call: FET Proactive: emerging paradigms and communities (H2020-EIC-FETPROACT-2019, 2019)
Start date: 2020-10-01
End date: 2025-03-31
Duration (months): 54.0
Total project cost (EUR): 3901014.75
EU funding (EUR): 3901005.75
Participants: 7
Project status: SIGNED

FORGETDIABETES introduces a radically new approach to Type 1 Diabetes (T1D) treatment, by developing an immuno-optimized, fully-implantable, fully-automated, Bionic Invisible Pancreas (BIP). BIP targets physiological intraperitoneal hormone delivery, enabling an optimal glycemic control. T1D patient number is rising, projected at 63-94 million in 2045. T1D patients require exogenous insulin, resulting in an exorbitant number of actions: 100.000-500.000 in one patient’s life. BIP will free T1D subjects from therapeutic actions and from related psychological burden. BIP will become a life-condition (like wearing glasses), allowing T1D patients to live just as everybody else. An interdisciplinary team with top experts in micro-nano mechatronics, control engineering, biomaterials, endocrinology, surgery and behavioural sciences has been assembled to develop what was regarded as impossible for decades: a long-lasting system relying on a physiological glucose sensing and hormone delivery, orchestrated by personalized adaptive algorithms with advanced self-diagnostic capabilities. Pump refilling through a weekly oral recyclable drug pill will free T1D subjects from the burden of painful and awkward daily measurement and treatment actions. Wireless power transfer and data transmission to cloud-based data management system round-up to a revolutionary treatment device for this incurable chronic disease. In this project, the key technologies enabling BIP will be developed. Furthermore, extensive in vivo preclinical experiments along with massive in silico testing will establish the proof-of-principle, paving the way to the ambitious first-in-human inpatient trial of BIP. This paradigm will revolutionize diabetes treatment and stimulate an innovation ecosystem including research bodies, SMEs, patient organizations, diabetes societies and clinicians. By investing in efforts like FORGETDIABETES, Europe will stand at the forefront of technological innovations for T1D treatment.

Keywords: artificial organs,diabetes,endocrinology and metabolism glucose nano sensing,intraperitoneal insulin delivery,personalised and adaptive control algorithms,modeling and simulation
The validation, certification and industrial testing of advanced road marking retro reflectance (RL) measuring equipment (RetroTek-M) for the global market. (DuaLine)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Ireland
Call: Small business innovation research for Transport (H2020-SMEINST-2-2015, 2015)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 1416516.25
EU funding (EUR): 991561.38
Participants: 1
Project status: CLOSED

RMS Ltd is developing road marking retro reflectance (RL) measuring equipment (RetroTek-M) for the global market. The Dualine proposal is to enable RMS Ltd to complete the development of this equipment from a TRL 7- Demonstration system to TRL 9 – full commercial application, technology available for customers. The advantages RetroTek will deliver relative to the current state of the art are significant and game changing. RetroTek will provide a 50% reduction in the cost of line inspection by performing a two line inspection (one either side of a road lane) on one pass, compared to single line inspection by the current state of the art. Customers such as Road Marking Contractors, Road Survey Companies and Road Authorities are requesting improvements in RL measuring equipment such as driver-only inspection, vehicle flexibility, no lane closure requirements during inspection and real-time data, all of which RetroTek provide. This project will provide significant commercial benefit to RMS Ltd in increased revenue, to its customers in significant cost savings and to the wider community by providing a much safer night-time driving environment. Dualine proposal is an integral part of and fully compliments the business strategy of RMS Ltd. This proposal addresses many of the aims of the Council as detailed in Framework Programme for Research & Innovation(2014-2020) relating to Smart Green and Integrated Transport ref: 2011/0402(CNS), The technology is an efficient maintenance and inspection system (4.1.2); It reduces traffic congestion by eliminating road closures and efficiently uses and manages surface transport infrastructure (4.1.2);gives road authorities a tool to maintain safety standards and assists towards the target of zero fatalities in road transport by 2050 (4.2). Researched and developed in the EU, it assists Europe’s aim of becoming the world leader in efficiency and safety in all modes of transport (4.3).

Keywords: retro reflectivity,reflectivity,retro,roadway,line,marking,rpm s,raised pavement marker,cats eyes,road vision,vision,stripes,strips,motorway,highway,carriageway,dual,dualine