Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Searchable multi-dimensional Data Lakes supporting Cognitive Film Production & Distribution for the Promotion of the EuropeaN Cultural HeritagE (SCENE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Greece,Italy,Germany,Portugal,Spain,Belgium,Cyprus
Call: Increase the potential of the international competitiveness of the European filmmaking industry (HORIZON-CL2-2022-HERITAGE-01, 2022)
Start date: 2023-02-01
End date: 2026-01-31
Duration (months): 36.0
Total project cost (EUR): 3966875.0
EU funding (EUR): 3966875.0
Participants: 14
Project status: SIGNED

The SCENE project has been majorly designed to offer the means for a modern & globally competitive, European filmmaking industry, by building upon two solid pillars, i.e. semantically cognitive AI technologies and the (in) tangible European Cultural assets, always with respect to the European values & policies regarding the human and its environment. SCENE will develop a wide set of cutting-edge technologies & services that are able to cover the whole pipeline of the film-making industry, “from farm to fork”, i.e. from the very early stages of the film planning until their playback at the audience screen. Specifically, SCENE aims to innovate by enriching the existing data lakes with high-qualitative & editable 3D digital models of European cultural sites, and by enhancing their accessibility with the integration of multi-dimensional knowledge graphs carrying location- & cultural-aware information. SCENE will further facilitate the film-making & film-editing side during the production & the post-production phase with efficient simulation & novel assessment mechanisms. Similarly, it will enable a smart & privacy-preserving interaction channels between industrial stakeholders & the audience, that will allow not only for pro-active sensing of the audience’s preferences in the pre-production phase, but also for the early identification of the most matching advertisement & distribution channels during the distribution phase, as well as the insightful matching & recommendation between films & individuals. The integration of the aforementioned technologies under the unique SCENE platform demonstrates significant capacity to render an excellent proof-of-concept prototype to guide, inspire and mark significant breakthrough in the film making industry during the post COVID era, on scientific, commercial, business & policy level.

Keywords: filmmaking,blockchain,3d reconstruction,cultural heritage,data lakes,ontologies,audience building,trend analysis,distribution engine,recommender system,acoustics and light simulation and effects
Multisystem imaging of whole-body emotion circuits with total-body positron emission tomography (TOTALBODY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Finland
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2455842.5
EU funding (EUR): 2455842.5
Participants: 1
Project status: SIGNED

The goal of the TOTALBODY project is to establish the interacting biological networks supporting human emotions and their disorders across the brain and periphery using novel total-body positron emission tomography (PET) approach. The body-to-brain axis maps visceral signals onto emotions, driving complex motivated behaviours. Negative emotions are risk factors for cardiovascular diseases (CVDs) Conversely, CVDs are associated with anxiety, highlighting the link between negative emotions, bodily functions, and somatic health. Systems-level interaction between brain and peripheral organs could thus be a key pathway underlying psychiatric disorders, but it remains poorly understood. TOTALBODY tackles this question from ground-breaking viewpoint by implementing novel total-body PET approach for measuring the physiology of the emotion circuits across the brain and body, creating an innovative multisystem biology approach for studying emotions. We simultaneously map activity in the brain and peripheral organs during pharmacologically and psychologically induced emotions in a large sample (n=240) of healthy volunteers and patients with generalized anxiety disorder (GAD). Links between CVDs, GAD, and whole-body emotion circuit activation are mapped in a clinical study involving 300 patients with suspected CVD. The data are analysed using state-of-the art multi-organ modelling framework developed in the context of the project. Advanced pattern recognition techniques implemented on the whole dataset (540 subjects) are used for discerning the central-peripheral pathways associated with future onset of anxiety and CVD. Anxiety and CVDs constitute a major burden for health and well-being worldwide. This unique large-scale analysis of the central-peripheral axis of anxiety and cardiac functioning enables delineating biological and psychological mechanisms that generate the central and peripheral anxious state and burden the cardiovascular system predisposing individuals to CVD.

Keywords: emotion,anxiety,positron emission tomography,embodiment,anxiety,cardiovascular diseases,psychophysiology
Quantifying temporal patterns of viral mortality in soil (MeMori)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1547500.0
EU funding (EUR): 1547500.0
Participants: 1
Project status: SIGNED

Atmospheric CO2 levels are affected by sources (industrial processes, respiration) and sinks (carbon fixation, storage of organic carbon). Viruses that infect microorganisms may play an important role in soil carbon sink properties. In soil, carbon is stored, or sequestered, by binding to minerals. Recent studies show that long-term mineral-associated matter is mostly microbial debris, and its fraction out of soil organic carbon varies by soil type. Hence, viruses that break microbial host cells create microbial debris and contribute to carbon sequestration in soil, yet are missing from carbon flux models. We lack fundamental information about the physiology of soil viruses to link viral lysis of microbes and soil carbon sequestration. Recently, we provided the first estimate of microbial mortality by viruses during soil re-wetting after the dry season, a peak time of carbon flux. Our study estimated mortality of up to 46% of cells within a week. The main knowledge gaps preventing better accuracy of mortality estimates are the average number of viruses produced per host cell and infection rates year-round. I propose to address these gaps using a combination of classic microbiology and cutting-edge bioinformatics. This project will: (1) generate physiological constraints for soil viral mortality across soil types with different amounts of microbial debris, and (2) establish a multi-year monthly time-series of viral infection dynamics of soil microorganisms. I will focus on soil viruses infecting Actinobacteriota, an abundant phylum of drought-resilient soil bacteria that experiences consistently high viral infection rates. A time-series of viral activity will place the culture-based physiological parameters within the context of spatiotemporal dynamics of the entire viral community. This project will create an unprecedented ability to estimate the potential contribution of viruses to soil carbon sequestration and incorporate it into global carbon flux models.

Keywords: soil viruses,microbial physiology,carbon sequestration,phage
Rylenediimide-(Bis)triazinyls: Synthesis, Characterization, and Magnetic Properties (RYLTAZ)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Cyprus
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 164328.0
EU funding (EUR): 164328.0
Participants: 1
Project status: CLOSED

Polycyclic aromatic hydrocarbons (PAHs) with stable open-shell ground-states are needed for state-of-the-art applications, e.g., organic spintronics, electronics, energy storage etc. Herein, we propose rylenediimides (naphthalenediimide; NDI / perylenediimide; PDI) as promising PAH scaffolds for building multifaceted Blatter-type (di)radical conjugates that are typically inherently stable but also readily prepared. The introduction of [e]-ring fusion of the triazinyl moiety (Blatter-type) promotes planarization and rigidity of the rylenediimide core to allow spin delocalization, which electronically stabilizes the rylenediimides-(bis)triazinyl conjugates: DFT calculations support the high spin delocalization across the N−C−N−N tetrad (triazinyl) unit and the π backbone (NDI/PDIs). Three rylenediimide-mono(triazinyl) and two rylenediimide-bis(triazinyl) conjugates will be prepared and studied. The latter were selected from DFT computational studies of eleven possible NDI/PDI-bistriazinyl conjugates owing to low singlet-triplet energy gaps (< –1 kcal/mol) that indicate potential singlet biradical behavior. The triplet states of these conjugates could be accessible by heat or light which will open up the opportunity of having desirable switchable materials. The selected five rylenediimide-(bis)triazinyl conjugates will be synthesized via our previously optimized straightforward synthetic protocols. After standard characterization, magnetic and spintronic properties (conductivity and film forming properties) will be investigated. Single crystal X-ray crystallography, EPR and SQUID studies will validate spin states, singlet-triplet energy gaps, and solid-state magnetic properties. The project will advance the field of organic electronics.

Keywords: 1 stable organic radical,2 singlet diradical biradical,3 low singlet triplet energy gap,4 rylenediimide,5 naphthalenediimide ndi,6 perylenediimide pdi,7 heterocyclic chemistry
Artificial User (Artificial User)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Finland
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2499208.0
EU funding (EUR): 2499208.0
Participants: 1
Project status: SIGNED

PROBLEM: Despite decades of research on human-computer interaction (HCI), the problem of how to predict human performance with a given user interface (UI) is unsolved. Existing computational models are limited in scope or require large datasets or expert input. Instead, empirical methods are used that are costly and error-prone. OBJECTIVE: This project establishes the foundations of simulation intelligence in HCI through computational rationality. Given a design and a task environment, a simulator generates human-like moment-to-moment behavior autonomously, from which key metrics can be computed, i.e. for learning, performance, and ergonomics. ”Artificial users” can be commanded using natural language without modeling expertise. APPROACH: We seek a breakthrough through the theory of computational rationality that would dramatically expand the models’ scope and actionability. The theory posits that interactive behavior is an emergent consequence of a control policy adapted to internal bounds (cognition) and rewards. While previous work has demonstrated progress, scope has been limited to simple sensorimotor tasks and required reward engineering. This project will study the principles of computationally rational agents that learn skills like humans, can operate autonomously and yet be commanded via natural language. We design a workflow for building dramatically larger models via self-supervised pretraining. IMPACT: We develop a strong complement to existing evaluation methods in HCI. The pushes forward generative modeling in HCI by combining theory-driven causal assumptions about people and modern ML, while being deployed directly in high-fidelity simulators. This allows dealing with novel task environments with higher accuracy. This will be a leap forward in applications of design and engineering (rapid evaluation) and ML (realistic synthetic data) in HCI.

Keywords: human computer interaction,simulation models,user modelling,user interfaces,cognitive modeling,evaluation methods,generative models,computational rationality,reinforcement learning
Simultaneous solar hydrogen and value-added product generation by inexpensive photoelectrodes (SolarHyValue)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Hungary
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 157622.4
EU funding (EUR): 157622.4
Participants: 2
Project status: SIGNED

The role of solar energy and the need for clean fuels (such as hydrogen) is essential in achieving a net zero future. A sustainable way of green hydrogen generation is photoelectrochemical water splitting, which uses only solar energy and water to produce green hydrogen and concomitantly oxygen. This technology, however, with the currently demonstrated efficiencies is not cost-competitive. A less explored application of photoelectrochemical devices is the generation of a value-added oxidation product from abundant polymeric waste materials (e.g., biomass, plastics), instead of the low market value oxygen. Such a device can lead to a reduced energy consumption (compared to water splitting), as well as high market value anodic product. Excitingly, in this approach green hydrogen is generated as a by-product (virtually free) on the cathode. The SolarHyValue project proposes the use of perovskite and organic photoactive layers with a protective sheet to fabricate stable photoelectrodes for simultaneous solar hydrogen and value-added product generation. Efficient bias-free operation of waste valorisation with photoelectrochemical device was only demonstrated with expensive precious metal catalysts (platinum, palladium). The proposed large bandgap caesium lead halide perovskite layer has the potential to enable bias-free, and at the same time efficient photocurrent generation even with the use of solely earth-abundant materials. This will be allowed by the novel device design and the development of a transition metal dichalcogenide (MoS2) catalyst doped at its basal plane with non-precious metal heteroatoms, resulting in excellent catalytic activity. Through increased scientific understanding the SolarHyValue project will lead to the first ever demonstration of a photoelectrochemical device that allows simultaneous, bias-free production of solar hydrogen and value-added product relying solely on inexpensive materials.

Keywords: photoelectrochemical,solar hydrogen,value added product,perovskite,organic,transition metal dichalcogenide,photoactive,photoelectrode,2d materials,catalyst
The OVAL study for VB-111 treatment of platinum-resistant ovarian cancer (OVAL)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-04-01
End date: 2024-03-31
Duration (months): 24.0
Total project cost (EUR): 7037500.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

VBL therapeutics is a late-stage clinical biopharmaceutical company focused on first in class treatments for cancer. VBL's lead oncology product candidate, VB-111, is an innovative targeted anti-cancer gene therapy with potential to treat a wide range of solid tumors. Most cancer therapies aim to target tumors cells while sparing normal cells, but tumors are heterogeneous and often develop resistance to treatment. Instead of targeting the tumor directly, VB-111 targets the tumor environment by disrupting the blood vessels that supply blood to the tumor and by recruiting the immune system into the tumor. This dual mechanism of action together with an excellent safety profile make VB-111 a game-changer. VBL is pursuing Ovarian Cancer as the first indication for VB-111. In the scope of this project, VBL will to finalize a Phase 3 potential-registration clinical trial, the OVAL study as well as execute all the necessary steps towards final regulatory approvals and commercialization

Keywords: ovarian cancer
SCALING UP FRIDGE-FREE VACCINES STABLE AT +40°C (SUFFVSA40C)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-06-01
End date: 2027-02-28
Duration (months): 21.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

At Stablepharma, our mission is to revolutionise vaccine distribution and storage by leveraging our proprietary StablevaX™ technology platform which results in the production of vaccines that are thermostable and do not require temperature controlled storage or distribution. Our technology can be applied to over 60 existing and currently, approved vaccines and our business model enable us to reformulate and thermostabilise existing, vaccines in partnership with vaccine manufacturers. By eliminating the need for cold-chain distribution and storage, we aim to enhance global access, reduce vaccine wastage, lower costs, and cut carbon emissions, all while enabling strategic stockpiling of vaccines. Our lead product is SPVX02 (a thermostable tetanus and diphtheria (Td) vaccine) and is currently positioned to enter the largest global human vaccine market by dose volume (tetanus and diphtheria-containing vaccines) aside from COVID-19 in recent years. SPVX02 addresses critical challenges in vaccine distribution and storage, especially in regions where cold-chain logistics create barriers to vaccine access. By stabilising vaccines at ambient temperatures, we extend the reach and impact of life-saving vaccines, to all populations worldwide. With the support of EIC funding, we intend to rapidly progress SPVX02 through a pivotal Phase 2b Clinical Trial, whilst collaborating with a range of EU-based manufacturing, clinical, and regulatory partners, before working with commercial distribution partners to apply for Market Authorisation in the EU and other regions. Ultimately, we plan to expand our portfolio to include additional thermostable vaccines and pharmaceuticals using our proprietary StablevaX™ technology platform enabling us to achieve our vision of saving lives and reducing wastage globally.

Keywords: vaccine,thermostable,biotechnology
Collective dynamics in Rydberg arrays (CODRA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-03-01
End date: 2027-02-28
Duration (months): 24.0
Total project cost (EUR): 183600.96
EU funding (EUR): 183600.96
Participants: 1
Project status: SIGNED

In recent years, neutral atoms in tweezer arrays have gained prominence as scalable platforms for a variety of quantum technology applications, primarily due to the powerful collective dynamics offered by the Rydberg blockade mechanism. As the platform’s size continues to grow, there is an increasing theoretical emphasis on devising protocols that predominantly utilize global atom driving, given the persistent challenges associated with individual atom addressing. In this research proposal, the Applicant will deepen the understanding of the complex collective dynamics inherent to Rydberg arrays, with the objective of formulating innovative, scalable protocols that minimize the reliance on local controls. He will investigate a brand new set of dynamics, made accessible via the strategic inclusion of proper arrangement of atoms – superatoms and Rydberg gadgets – for quantum computation and optimization purposes, leveraging the Host’s deep expertise in the field.

Keywords: rydberg physics,neutral atoms,quantum optimization,quantum computation,quantum optimal control