Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Genetic control and molecular mechanisms of cell wall modifications during sieve pore morphogenesis in the phloem of the plant vascular system (SiPoMorph)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The plant vasculature comprises the xylem and phloem. The phloem’s conductive cells, the sieve elements, transport sugars produced in leaves to sink organs, such as roots, tubers, fruits and seeds. They also transport hormones and RNAs throughout the plant, enabling its adaptive and continuous development. Individual sieve elements connect through callose-rich sieve plates to form sieve tubes, the larger supra-cellular conducting units. Perforation of the sieve plate with sieve pores is critical to efficient sap flow and can be modulated by callose-mediated occlusion. Indeed, sieve pores are rapidly closed in response to tissues damage, abiotic stresses and infections. Cellular differentiation and adaptation of sieve elements, particularly sieve pore morphogenesis, are surprisingly poorly understood and, lacking powerful cell-biological tools, has largely been neglected. This project sets out to describe a molecular and genetic framework for sieve plate formation. To this end, mutants and transgenic lines already generated in the host lab will be characterized. Additionally, candidate genes, encoding mostly for unknown proteins will be localized in sieve elements. These genes will be functionally characterized using several state-of-the-art methods and specifically-tailored molecular tools, such as inducible CRISPR knock-out, laser ablation and dominant cell-specific genetic interference. This will identify novel molecular players during callose deposition and degradation at sieve pores and advance our mechanistic understanding of sieve plate formation and possible adaptive mechanisms of stress response. Morphological variances and developmental adaptations of sieve pores are important for phloem source-to-sink transport and nearly all calories consumed by humans and livestock have at some point passed through sieve pores. Hence, understanding their morphogenesis at the molecular level is equally relevant for fundamental plant science as for modern agriculture.
Fostering transnational cooperation between National Contact Points (NCP) in the area of quality standards and horizontal issues (NCP Academy)

Framework: Horizon 2020 — Science with and for Society
Action type: Coordination and support actions
Countries involved: Austria,Germany,Spain,Italy,Ireland,Cyprus,Switzerland,Belgium,Finland,Finland,Croatia,Moldova, Republic of,Greece,Poland,France,Czechia,Portugal,Portugal
Call: Fostering transnational cooperation between National Contact Points (NCP) in the area of quality standards and horizontal issues: follow-up project (H2020-IBA-DEE-NCP-2018, 2018)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 799965.0
EU funding (EUR): 799965.0
Participants: 18
Project status: CLOSED

The NCP Academy is a continuation and expansion of the former NCP Academy support action (2014-June 2018) covering the period September 2018 to August 2020. The project brings together Horizon 2020 NCP Coordinators and Legal and Financial NCPs to implement training on cross-cutting issues for National Contact Points and address quality standards and good practice. It aims to build capacity measures tailor-made for the needs of the NCP community by implementation of a high-quality training programme and provision of opportunities for the exchange of experiences and of good practices. It maps NCP clients` needs and their satisfaction levels and provides central services to the stakeholders/users of the Legal and Financial NCP services. The NCP Academy consortium will cooperate closely with other NCP Networks to implement procedures that ensure a timely flow of information allowing collaboration. It will focus on removal of any duplication between networks and new routes to efficiencies of implementation. It supports the European Commission in providing feedback and analysis. Thus, this project serves as vehicle for building up and mobilising expertise, contributing to future developments. The project addresses the continuous concerns that the programme evolves during its lifetime (2018-2020), that lessons are learned, and that newcomers join the NCP network. It goes some way towards ensuring that adequately trained NCPs will be in place upfront for the next Framework Programme, Horizon Europe. The NCP Academy includes activities aimed at helping NCPs in those countries that have been participating at lower levels in the programme up to now, for example, training, mentoring, twinning and awareness raising actions aimed at increasing visibility of well-qualified potential applicant organisations in those countries.

Keywords: national contact points,training,cross cutting issues
Predictive Analysis on the Worldwide Energy Sector (PAWES)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The context in the energy sectors is particularly favourable to adopting new methodologies, especially in view of the arising opportunities and developing knows-how in big data analytics, in order to answer the constant need for more accurate projections of the energy sector’s perspectives (Oil & Gas and renewable energy as well). Kayrros offers services radically different from the technologies currently used in the energy sector and the Fintech applied to energy markets. The novelty of Kayrros’s approach is mainly related to technological innovations. These innovations allow to set up energy indicators solely based on publicly available information, possibly charged but available to anyone. Kayrros has thus developed alternative methods to bypass the lack of relevant straightforward information. The accuracy and reliability of the information provided, as well as the reduced delays to deliver them, are at the core of Kayrros business model. As an information provider, Kayrros is part of the Business intelligence (BI) market for the energy sector. Its services aim to support trading activities and strategic investments, and address a wide range of stakeholders such as oil companies, commodity department of investment banks, oil trading companies, refineries, or equity funds, hedge funds, energy intensive industries, etc. With this SME Instrument project, Kayrros’ ambition is to boost the development of the company so as to become a worldwide leader in the business intelligence for the energy sector. The project will result for Kayrros in 50 m€ of increased revenues by 2021 and 87 job creations.

Keywords: predictive analysis,big data,machine learning,text analytics,image analysis,energy markets,oil and gas,renewable energy,fintech
The Impact of Polymer Dispersity and Monomer Sequence on Self-healing and Photodegradation of Dynamically Crosslinked Polymers (DISCOSH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-15
End date: 2024-01-14
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

Dynamically crosslinked polymer materials (DPMs) have tremendous potential in the development of the next generation of smart functional materials. The presence of dynamic or reversible bonds in the system allows DPMs to display a significant number of beneficial properties such as self-healing, (re)processability, and shape-memory which will enable an extended lifetime, with reduced replacement costs, and improved performance against mechanical challenges. Recently, substantial interest has been developed to improve the properties of DPMs through various dynamic chemistries and structural features of polymers. Similarly, dispersity, molecular weight distributions (MWDs), and monomer sequences play a vital role in governing material properties and functions. However, there is a requirement for a deeper understanding of how the dispersity, MWD, and monomer sequence impact the properties of DPMs. Project DISCOSH is anticipated to study the missing link between MW of dynamic polymers to their thermomechanical properties. The dispersities, MWDs, and monomer sequences of the underlying co-polymer will be tuned to understand the structure-property relationship of DPMs for their thermomechanical properties, self-healing behavior, and degradability of the DPMs. The multidisciplinary nature of the project involves merging one of the top ten emerging technologies in polymer chemistry (controlling polymer dispersity through living polymerization) with the advances in material properties. The fellow’s expertise in material synthesis, characterization techniques, and polymer degradation will be combined with the host’s advanced skills in the sequenced and dispersity controlled polymerization to obtain a deeper and essential understanding of the importance of the dispersity and sequence-controlled polymerization to achieve beneficial dynamic properties for next-generation materials.

Keywords: dispersity and sequence controlled polymerization,dynamically crosslinked materials,and thermomechanical properties
Personalized Cancer Immunotherapy through DNA-EP vaccines (TK-NEO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

TK-NEO is a DNA-based Neoantigen Cancer Vaccine (NCV), for use as therapeutic vaccination in patients with locally advanced or metastatic solid tumours. NCVs are a new form of precision medicine and are a perfect clinical approach for highly heterogeneous tumors in patients with metastatic disease. Takis has developed and patented a unique method for production of patient-specific NCVs based on a 6-week process, from sequencing the specific tumour DNA, synthesis of the right DNA sequence for the specific tumour, delivery through a specific Electroporation (EP) technology used under exclusive license. The solution was proven at pre-clinical stage to reduce to zero a human lung cancer in humanized mice in 60 days and to increase the efficacy several fold with respect to alternative RNA and DNA based NCVs in protecting relapse and boosting immune responses as required for the maintenance of long-term anti-tumor immunity. The strategy to reach the market for TK-NEO is to license the IP of TK-NEO to a large pharma company, after completion of clinical validation trials to demonstrate the applicability and safety of the approach: phase I clinical trials in melanoma are targeted during SME Instrument project, while implementation of a GMP manufacturing to carry out phase II clinical trials and the implementation of the trials will require additional 5M investment. The Total Available Market is constituted by melanoma patients who underwent surgery and first chemotherapeutic treatment, who are estimated in the order of 30.000 patients per year combining EU and US. The objectives of the feasibility study are: 1) to validate the feasibility and the authorization process for the release tests, 2) to confirm investment, cost and pricing for TK-NEO, 3) to define a MoU with VC or with the final client (pharma) for the co-financing of the clinical development of customized TK-NEO and for future licensing.

Keywords: neoantigen cancer vaccine,cancer immunotherapy,synthetic plasmid dna fusion,electroporation,melanoma,lung cancer,personalized vaccines
Sustainability assessment methods and tools to support decision-making in the process industries (SAMT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Coordination and support actions
Countries involved: Spain,Germany,Germany,Spain,Germany,Switzerland,Norway,Finland,France
Call: Methodologies, tools and indicators for cross-sectorial sustainability assessment of energy and resource efficient solutions in the process industry (H2020-SPIRE-2014, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 514804.38
EU funding (EUR): 498554.0
Participants: 12
Project status: CLOSED

Sustainability assessment methods are needed to support sustainable technology development and to evaluate the impacts of existing solutions, products and technologies. While there are aspects and indicators that are common to all process industries, sector specific tools are required to address the sector specific features in a fair and transparent way. At the moment, several tools, assessment methods and indicators exist, but they differ in their goal and scope and are intended for different kind of use within companies, by consumers or by authorities to support policy planning and evaluation. Additionally, different tools are focused for different levels of assessment: product, company, industry or society. Thus the problem is not so much the existence of proper tools but rather the lack of understanding and knowledge on how they should be applied and in which context. Furthermore, suitable tools for analysing resource and energy efficiency within the process industries and across the different sectors should be recognized. The aim of the SAMT project is to review and make recommendations about the most potential sustainability assessment methods for evaluating energy and resource efficiency in the process industry. The analysis will focus on the applicability of different methods in industrial settings, the ability of the methods to support decision-making towards sustainable solutions and the suitability of the tools for cross-sectoral analysis. SAMT will evaluate tools that cover either environmental, economic and social aspects, or a combination of these, and apply principles of life cycle thinking. The project will consider demands and make recommendations related to sectorial and cross-sectorial assessment in a wide spectrum of process industries: cement, metal, oil, water, waste and chemical industry. To maximize the impact of the project the work will be supported by active dissemination activities including an implementation strategy as an outcome.

Keywords: sustainability assessment method,tool,life cycle thinking,slca,resource efficiency,energy efficiency,decision making,process industry,sector specific,cross sectoral
Majorana Fermions in Topological Insulator Platforms (MajoranaTopIn)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-05-01
End date: 2022-10-31
Duration (months): 66.0
Total project cost (EUR): 2406250.0
EU funding (EUR): 2406250.0
Participants: 1
Project status: CLOSED

Majorana fermions were recently discovered in topological superconductors as exotic quasiparticles having the curious property of being their own antiparticles. They are not only interesting as novel relativistic quasiparticles, but are also useful for realizing fault-tolerant quantum computers. However, currently available platforms to materialize Majorana fermions are limited, and the existing platforms have respective drawbacks for actually building qubits for a scalable quantum computer. Also, various unusual properties are predicted for Majorana fermions, but few have been experimentally addressed. To make a leap in the Majorana-fermion research which is technically highly demanding, one needs to grow state-of-the-art materials and tightly combine them with mesoscopic device research. By performing such an integrated research efforts in the same laboratory, this project aims to explore new platforms for Majorana qubits and to establish new methodologies to address peculiar physics of Majorana fermions. As new platforms, we pursue (i) three-dimensional topological-insulator nanoribbons and (ii) ferromagnetic topological-insulator thin films, both of which will be proximity-coupled to an s-wave superconductor. Each of them allows for conceiving Majorana qubits based on different principles, which will be tested in this project. Also, by developing new methodologies, we will elucidate (i) non-Abelian statistics probed by interferometry and (ii) quantized/universal heat transport phenomena probed by thermal conductance. These works will be complemented by materials growth efforts involving molecular beam epitaxy and detailed characterizations of the local electronic states using scanning tunnelling spectroscopy. If successful, this project will not only contribute to the realization of scalable quantum computers, but also elucidate the non-Abelian statistics, which is a fundamentally new property of particles and is ground breaking in physics.

Keywords: topological insulators
Social Sustainability and Urban Regeneration Governance: An International Perspective (SURGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2020-08-31
Duration (months): 36.0
Total project cost (EUR): 255349.8
EU funding (EUR): 255349.8
Participants: 2
Project status: CLOSED

The aim of the research is to support the career development of an experienced researcher through an interdisciplinary project that tackles a crucial policy issue for cities globally, that of urban regeneration governance. Developing a novel interdisciplinary conceptual framework, and applying a stakeholder evaluative frame in the analysis, the project explores the governance of urban regeneration projects in two world cities, Vancouver and London. The scientific objectives of the research are: to develop an innovative theoretical framework that integrates different disciplinary perspectives on urban governance; to critically analyse the dynamics of urban regeneration governance and in particular the role of different stakeholders in the process; and to provide research and policy recommendations for dissemination to wide audiences. The outgoing host is the University of British Colombia, Vancouver, at the School of Community and Regional Planning (SCARP), while the return phase will be hosted at Oxford Brookes University (OBU). Both SCARP and OBU provide ideal hosts for the fellow, offering a strong multidisciplinary environment, a network of international contacts, and an outstanding track record of training researchers. The research training objectives of the proposal are to train the fellow in a new methodology, digital ethnography, which she will then apply to the research; to complement the researcher’s knowledge of urban governance in the UK with in-depth understanding of the Canadian case, and so develop a comparative urbanism perspective; to participate in seminars and other events organised by the outgoing and return hosts; and to interact and collaborate with international scholars from different disciplines in areas of mutual interest. In order to maximise the impact of the research, the fellow will also undertake a three-month secondment at a Paris-based NGO, European Alternatives, where her findings will be exploited in real life regeneration settings.

Keywords: urban governance,urban regeneration,community engagement
Investigation of carrier multiplication in van der Waals heterostructures for highly efficient solar cells (CAMPVANS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Presently, the two-dimensional (2-D) crystals and their van der Waals heterostructures (vdWHs) are attracting a lot of attention from the scientific community due to the unique features that they offer such as the possibility to widely tune their band gap, study strong light-matter interactions at the ultimate thickness limit. These features are of great relevance for the light harvesting applications as in photodiodes and photovoltaic cells. In this project, we propose to optimise the (opto-)electrical and photovoltaic behaviours of these components. The state-of-the-art ab-initio quantum transport solver relying on the density-functional theory and the Non-Equilibrium Green’s Function formalism will be employed to simulate the I-V characteristics of single- and multiple-junction vdWHs as well as their optoelectronic and photoresponse properties. Electron interactions with phonons and photons will be taken into account to ensure very accurate performance predictions. The validity of our models will be tested by comparing our results for vdWH-based devices with experimental data from our collaborators. These results will advance our understanding of the light-matter interaction in the atomistic scale vdWH junctions. We will then investigate whether the innovative idea of using the inter-layer carrier multiplication will lead to significant improvement of the light conversion efficiency of the photovoltaic cells. Novel vdWH-based superlattice photovoltaic cells will be designed and optimised with the precisely calibrated atomistic simulator. The most promising device configuration will serve as reliable design guidelines for our experimental collaborators so that the designed devices can be manufactured and characterised. This project aims to significantly increase the light conversion efficiency of vdWH-based solar cells by enabling the cascade inter-layer carrier multiplication.

Keywords: 2 d materials,van der waals,ab initio,quantum transport,non equilibrium green s functions