Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Altered eco-evolutionary feedbacks in a future climate (ECOFEED)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: France
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-04-01
End date: 2025-03-31
Duration (months): 72.0
Total project cost (EUR): 1983565.0
EU funding (EUR): 1983565.0
Participants: 1
Project status: SIGNED

Current scenarios predict an accelerated biodiversity erosion with climate change. However, uncertainties in predictions remain large because the multitude of climate change effects from genes to ecosystems and their interdependencies are still overlooked. This incomplete vision hampers the development of effective mitigation strategies to sustain biodiversity. Climate change can directly modify the phenotype and performance of individuals through phenotypic plasticity and evolution on contemporary time scales. The microevolution of keystone species can spread throughout the whole ecological network due to changes in species interactions and further translate into an altered ecosystem functioning. Conversely, direct impacts on communities and ecosystems can have ripple effects on the phenotypic distribution and evolution of all species of ecological networks. Climate-driven changes at individual and population levels can shape community composition and ecosystem functioning, and vice versa, altering eco-evolutionary feedbacks, namely the reciprocal interactions between ecological and evolutionary processes. Climate-driven ecological and evolutionary dynamics are yet often investigated separately. The role of eco-evolutionary feedbacks in climate change impacts on biological systems therefore hinges on little concrete empirical evidence contrasting with a profuse theoretical development. ECOFEED will investigate climate-dependent eco-evolutionary feedbacks using a 6 year-long realistic warming experiment reproducing natural conditions and thus allowing for both evolutionary and ecological dynamics to occur under a predicted climate change scenario. Complementary laboratory experiments will quantify reciprocal impacts of climate-dependent evolutionary and ecological changes on each other. ECOFEED will provide unprecedented insights on the eco-evolutionary feedbacks in a future climate and will ultimately help refine predictions on the future of biodiversity.

Keywords: climate change,eco evolutionary dynamics,experimental ecology
Engineering magnetic properties of hexagonal boron nitride - based hybrid nanoarchitectures (WHITEMAG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

2D magnetic materials have attracted enormous interest over the last years because of their potential towards miniaturization of novel low-power and memory storage technologies. Isostructural and isoelectronic to graphene, an atomically-thin layer of hexagonal boron nitride (hBN) is electrically insulating, and one of the most prominent 2D materials because of its superior mechanical, thermal and especially chemical properties. Inducing magnetic properties (together with reducing the size of the bandgap) will allow the realization of full potential of hBN nanostructures in functional applications. In this line, the efforts reported to date lack characterization and control of the sample’s properties at the atomic level, which is crucial to achieve a comprehensive understanding of the physical phenomena driving the emergence of magnetic properties. WHITEMAG aims to create routes for controlled magnetic functionalization of hBN in order to induce and exploit emerging electronic and magnetic properties at the atomic scale. hBN will be precisely modified by exploring novel defect engineering methods to introduce substitutional magnetic atoms, and subsequently by designing hybrid nanoarchitectures that combine hBN with magnetic organic molecules. The structural, electronic and magnetic properties of these systems will be studied by STM/STS, XPS/ARPES, nc-AFM and XMCD, giving a complete picture of the phenomena occurring at the atomistic level. The synthesis and characterization experiments will be addressed based on a surface science approach, involving controlled dosing of molecular and atomic species on well-defined surfaces under ultra-high vacuum (UHV) conditions. If successful, the outcomes of this work will push forward the microscopic understanding of magnetic phenomena in low-dimensional systems, and will open new promising perspectives for the implementation of hBN-based nanostructures in future spintronics and molecular electronics applications.

Keywords: 2d magnetic materials,hexagonal boron nitride hbn,scanning tunneling microscopy,defect engineering,metallo phthalocyanines and porphyrines,magnetic properties and functionalities,kondo physics
Predicting Cardiotoxicity Induced by Kinase Inhibitors: From Systems Biology to Systems Pharmacology (CARDIOTOX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-12-06
End date: 2018-12-05
Duration (months): 36.0
Total project cost (EUR): 242929.8
EU funding (EUR): 242929.8
Participants: 2
Project status: CLOSED

Kinase inhibitors (KIs) are a major class of highly effective anti-cancer drugs. Unfortunately, therapeutic use of KIs is often associated with cardiotoxicity (CT), a serious adverse condition which limits their use. This fellowship aims to develop mathematical systems pharmacology models for KI-induced CT. These models will be used to identify predictive CT signatures that will allow to decrease CT risk of new KIs. This innovative multi-disciplinary approach consists of integrating mathematical systems pharmacology modelling, with state-of-the-art experimental data generation. To this aim, KIs with different magnitudes of CT will be selected based on clinical adverse event databases. Human cardiomyocytes derived from pluripotent stem cells will then be treated with the selected KIs and in combination with CT modifying drugs. The effect of these treatments on changes on untargeted mRNA and protein expression will be measured and then analyzed using network modelling. This approach allows identification of key regulatory proteins. The selected proteins will then be quantified over time along with cardiomyocyte health markers. With this data, dynamical models will be developed to capture the relationship between exposure to KIs and the effects on protein expression and cardiomyocyte health over time. Ultimately these models will allow generation of predictive network-based dynamically-weighted signatures for CT. The fellow aims to establish himself as independent researcher in systems pharmacology. Training in state-of-the-art computational and experimental technologies at the leading systems pharmacology group at Mount Sinai in New York will fundamentally strengthen and broaden the experience of the fellow. This project will significantly contribute consolidate the career track of the fellow, foster future collaboration between Mount Sinai and Leiden University, and disseminate training in Europe.

Keywords: cardiotoxicity,systems pharmacology,kinase inhibitors,systems biology,signatures,toxicity
Fast Thermalization of the Quark-Gluon Plasma (FastTh)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Understanding the properties of extreme phases of nuclear matter created in relativistic heavy ion collisions is one of the major challenges in theoretical physics. Matter under such extreme conditions was present in the very early universe and is nowadays produced in relativistic heavy ion collisions. In this proposal we address two questions that are central to the understanding of the very early stages of such collisions from the perspective of both strongly and weakly coupled field theory: What is the time-scale of the thermalization and why does it happen so fast? We will study these questions in the strongly coupled setup via the gauge/gravity duality by utilizing numerical relativity techniques to describe black hole formation in the gravity side. This allows to access real-time dependent non-equilibrium dynamical quantities and will improve the understanding of pre-equilibrium flow in heavy ion collisions. In order to understand thermalization at intermediate couplings we will carry out a comparison between strong and weak coupling approaches.

Keywords: heavy ion collision,quark gluon plasma,cft correspondence,high energy qcd,thermal field theory
Anaerobic Biotechnology for Sewage Sludge Treatment: Integrating Anaerobic Bioleaching with Anaerobic Digestion (AnBIOSST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

During wastewater treatment, a significant amount of sewage sludge (SS) is generated as a by-product, with an estimated production in Europe alone of 2 bio tons/yr. SS use as fertilizer and anaerobic digestion are 2 disposal routes that comply with current legislative guidelines on waste disposal and environment. Anaerobic digestion (AD) is widely applied, resulting in volume reduction and biogas production. However, high heavy metal (HM) contents in SS impede the use of raw SS or AD effluent to be used as fertilizer. Bioleaching is based on the activity of Fe-and S-oxidizing microbes, capable of degrading metal sulfides and solubilizing HM. Because of its potential to remove HMs from solid matrices, bioleaching has been considered as a promising technique for both raw SS and AD effluent. In this regard, studies have been performed on conventional oxidative bioleaching approach (OBL). However, the rate of HM dissolution through OBL is slow, it requires aeration and addition of leaching agents (acids, bases, etc), which increases costs. Also, the inevitable formation of by-products limits the process efficiency. Recently, anaerobic bioleaching (ABL) has been a choice to recover HMs of different sources,with benefits of acid production and minimization of by-products. However, up to now, ABL has not been introduced in SS treatment. Furthermore, the application of ABL to sewage sludge prior to AD digestion offers various potential advantages: (i) the bio-availability of HM (which serve as micronutrients to AD microorganisms) is increased, (ii) volatile fatty acids (VFA), very important AD intermediates, are produced; and (iii) the sludge is already in a reduced state before in enters the digesters. In this research project, we will obtain essential knowledge about (1) ABL as sludge treatment, and (2) the effect of ABL on the efficiency of subsequent AD. By filling these gaps in knowledge, we are one step closer to a clean-up and valorisation strategy for sewage sludge.

Keywords: anaerobic bioleaching,sewage sludge,heavy metals,anaerobic digestion,acidithiobacillus ferrooxidans
Navigating Schengen. Historical Challenges and Potentialities of the EU Free Movement of Persons, 1985-2015 (NAVSCHEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-02
End date: 2022-09-01
Duration (months): 36.0
Total project cost (EUR): 251002.56
EU funding (EUR): 251002.56
Participants: 2
Project status: CLOSED

NAVSCHEN will produce the first dedicated historical analysis of all worldwide available primary sources on the transnational roots, debates and conditions for the implementation of the European Union (EU)’s free movement of persons (henceforth, FMP). The project’s overall objective (OO) is to highlight: a) the value of critical historical analysis and b) the normative legacies on human mobility rights in the European integration process to address the current challenges of the EU’s FMP. This project aims to bridge this gap via the comparative analysis between the European Parliament (EP) and the European Commission (EC)’s role and impact on the changing modes of implementation of this Schengen Area ‘fourth freedom’. These two cases will be explored as part of a larger study on belonging and displacement in a ‘Europe in the making’. The project’s timeline will examine human mobility rights in light of the historical analysis of the European integration process from 1985 (the inception of the Schengen Area) to 2015 (a key turning point dominated by the public and private perception management articulation of responses to the so-called ‘refugee crisis’). Core questions: What are the evolving modes of exclusion in transnational mobility in Europe and beyond? How can historical critiques be relevant to today’s challenges to free movement of persons? What are the neglected solidarity and diversity dimensions of European integration? In this light, can we articulate responses to humanitarian dilemmas beyond security-centered conceptions of transnational mobility? And normatively, are narratives on ‘shared values’ in the EU and beyond, sufficient to mediate countervailing factors of exclusion? The main consulted archives will comprise the Historical Archives of the EU (HAEU), the Historical Archives of the European Parliament (HAEP) and the ‘Barbara Sloan European Union Delegation Collection (BSEUDC)’, currently hosted at the University of Pittsburgh Archives.

Keywords: european integration history,eu free movement of persons,discourse analysis,history of concepts,regional integration,migration,asylum,global governance
Realising Value from Electricity Markets with Local Smart Electric Thermal Storage Technology (RealValue)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Innovation actions
Countries involved: Ireland,Germany,Germany,Germany,Ireland,Ireland,Germany,Finland,Latvia,United Kingdom,United Kingdom
Call: Local / small-scale storage (H2020-LCE-2014-3, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 15413331.0
EU funding (EUR): 11987429.73
Participants: 16
Project status: CLOSED

RealValue aims to demonstrate how local small-scale energy storage, optimised with advanced ICT, could bring benefits to market participants throughout the EU. Smart Electric Thermal Storage (SETS) will be deployed in physical demonstration trials in 1250 homes in Germany, Latvia and Ireland but the analysis will also consider other storage technologies and energy vectors, including integration with district heating and micro-generation. SETS is a direct replacement for existing electric thermal storage heaters and water tanks with a combined load of 55GW across the EU. It can also replace direct electric resistance heaters with further connected load of 93GW. To validate the physical demonstrations at large scale RealValue will use modelling & virtual simulation to demonstrate the technical and commercial potential in millions of homes across representative EU regions. Thorough research studies are an integral part of RealValue and will include techno-economic and behavioural analysis that will be used to inform EU regulation and policy decision makers. RealValue will develop business models which quantify the potential of small-scale storage as an aggregated controllable load. It will provide system services or release value through price arbitrage within existing energy market structures, and highlight any barriers associated with integration into the electricity grid. The RealValue consortium is a truly cohesive partnership which has full participation and commitment from the whole energy supply chain. The consortium includes: technology developers (Glen Dimplex, Intel); energy system modelling specialists (UCD, DIW, RTU); energy market specialists (VTT); socio-economic experts (Oxford University); electricity network operators (ESBN, EirGrid) and energy utilities (MVV, SSE). RealValue is designed to accelerate innovation and develop business models necessary for small-scale storage, allowing it to form an integral part of the future EU energy landscape.

Keywords: household thermal storage,grid integration,aggregation,value realisation,business modelling,demand response,smart metering
Delineating the kinetic RNA interactome of nuclear exosome adaptor complexes (EXOonRNA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: SIGNED

The human genome is ubiquitously transcribed into far more RNA than is immediately needed. Consequently, RNA turnover becomes critical for keeping our cells healthy. The nuclear RNA exosome degrades the majority of short-lived RNA species within cell nuclei and is hereby the gatekeeper of an enormous RNA synthesis output. To perform this essential task, the exosome employs so-called ‘adaptor complexes’ (ExoACs), which contribute to target specificity. While the trimeric nuclear exosome targeting (NEXT) complex is specifically required for the degradation of short RNA transcripts, the poly(A) tail exosome targeting (PAXT) connection recruits the exosome to longer polyadenylated RNAs. Interestingly, and in contrast to NEXT, PAXT exhibits a rather complex nature. Besides the integral component RNA helicase MTR4 and the large scaffolding protein ZFC3H1, the proteins PABPN1, ZC3H3, and RBM26/27 participate in the RNA-targeting of PAXT. How assembly of all these proteins is achieved to commit a polyadenylated RNA for decay and how it is balanced with other nuclear RNA metabolic processes to avoid untimely decay of mRNA is unknown. Here, I will track the interaction of the RNA-binding components of NEXT and PAXT with newly synthesized RNA in human cells using a novel and cutting-edge temporally resolved CLIP (T-CLIP) methodology, which combines nascent RNA labeling using photoactivatable ribonucleoside analogue 4-thiouridine with the time course of UV crosslinking of protein-RNA complexes. Since the T-CLIP approach allows us to link ExoAC interaction profiles to RNA synthesis and turnover data, I will define the positioning and timing of ExoAC component interactions with nuclear RNA in real-time to understand how nuclear exosome identify and eliminate nonfunctional RNA. In achieving my aim, I will critically further our understanding of how the cells in our bodies manage to quality control their genetic information through the post-transcriptional control of RNA levels.

Keywords: rna turnover,clip,nuclear exosome
Fast Infrared Coherent Harmonic Microscopy (FAIR CHARM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Germany,Germany,Germany,Belgium,Lithuania,Hungary,Switzerland,France,France
Call: Disruptive photonics technologies (H2020-ICT-2020-2, 2020)
Start date: 2022-01-01
End date: 2025-12-31
Duration (months): 48.0
Total project cost (EUR): 5944726.25
EU funding (EUR): 5944726.25
Participants: 10
Project status: SIGNED

The emergence of innovative research avenues in biomedicine in the last decades (cell therapy, cancer immunotherapy, bio-nanotechnology) has led to many proof-of-principle demonstrations fostering the hope for new therapeutic strategies for diseases. However, the translation from a laboratory bench into clinical practice has often proven unproductive. One of the reasons for this failure in translation is in the absence of imaging instruments capable of encompassing both the subcellular length-scale, where pathogenic disorders are set in, and that of tissues with differentiated cell types required to organize spatial and temporal functionality. An instrument enabling translation should allow resolving three-dimensional features within this large spatial range and operating with the same physical observables at each length scale, also enabling millisecond temporal resolution to monitor relevant processes. These requirements are essential to elucidate the hierarchical and temporal connections between micro and macro structures and events. Multiphoton microscopy has a yet undiscovered potential to fulfill these needs. FAIR CHARM aims at bringing this technique to its full capacity by i) providing access to millimetre imaging depths by building a microscope (SWIM) with excitation in the Short-Wave Infrared Region relying on new laser sources, optimized optics, and ad hoc labelling probes; ii) enabling unprecedented acquisition frame-rates (kHz/s) by the Spectro-temporal Laser Imaging by Diffracted Excitation (SLIDE) approach; iii) adapting Deep Learning recognition algorithms to multiphoton observables. The consortium features photonics innovators, worldwide renown enterprises in laser technology and microscopy, and clinical and biomedical end-users selected within the oncology/immunology, regenerative medicine, and neural signalling fields to provide the scientific push and timely feedback during the development of the final devices: SWIM and SLIDE.

Keywords: multiphoton microscopy,clinical translation,short wave infrared,cytometry