Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Decrypting neuro-cancer crosstalk in pediatric cancers of the peripheral nervous system (CANEUTREAT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-02-01
End date: 2029-01-31
Duration (months): 60.0
Total project cost (EUR): 1836141.25
EU funding (EUR): 1836141.0
Participants: 1
Project status: SIGNED

Cancer neuroscience has emerged as a major axis of cancer biology, at the crossroad of two biological areas. Multi-layered dialogs between cancer and nervous contingents have started to be unravelled, with pivotal roles of the nervous system in tumor initiation, growth and invasion, in turn amplified by cancer-induced hijacking of nervous functions. Specifically, brain tumors were shown to be integrated in bona fide neuron-to-cancer synaptic networks but also to capture neural-activity dependent released factors that boost their tumor properties. In the last years, this completely rewired the view of high-grade gliomas, especially those arising in the pediatric population, suggesting specific vulnerabilities when neural networks are being shaped. The knowledge regarding neuro-cancer crosstalk in the peripheral nervous system (PNS) is far more fragmented, and is even obscure in malignancies arising within peripheral nervous tissues. Neuroblastoma (NB) is an emblematic, deadly, pediatric cancer of the PNS, with primary tumors that develop in sympathetic ganglia or in the adrenal gland. Despite its occurrence in sites of active central-to-PNS synaptic contacts, whether neural activity impacts on NB tumor features and metastatic progression is fully unknown. We have conceived a model of NB that reproduces the embryonic and nervous microenvironment in which it arises but also the sequence of its metastatic progression. Guided by preliminary data, the objective of the proposal is to decrypt the panel of neuro-cancer functional interplays in NB, at the anatomical, electrophysiological and molecular level. We will deploy multidisciplinary and cutting-edge approaches to provide a comprehensive and dynamic picture of neuro-NB dialogs, in relevant models for this pediatric cancer. Our underlying aims are to identify novel entry points for therapeutic strategies, and to define subtypes of NB that would benefit from neuro-related therapies.

Keywords: cancer neuroscience neuroblastoma peripheral nervous system embryonal cancer neuronal activity
Time-resolved imaging of membrane transporter dynamics under physiological ionic gradients (GRAIL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Netherlands
Call: ERC Synergy Grants (ERC-2023-SyG, 2023)
Start date: 2024-05-01
End date: 2030-04-30
Duration (months): 72.0
Total project cost (EUR): 11178784.0
EU funding (EUR): 11178784.0
Participants: 2
Project status: SIGNED

Without biological membranes, there would be no life as we know it. Lipid bilayers shield cellular content from the environment, creating defined micro environments with specific functionality. Transport of molecules and information across these membranes is carried out by integral membrane protein channels, receptors, pumps and transporters. Living cells maintain chemical gradients and electrical potential differences across their membranes, the potential energy of which can be accessed by the membrane proteins to perform useful work. Indeed, central processes such as metabolic energy generation and nerve impulse propagation directly depend on these membrane gradients. Due to their core role in the life of cells and in the health of living organisms, such proteins represent the majority of all current drug targets. Therefore, membrane proteins have been the focus of intense efforts to obtain high-resolution macromolecular structure information. However, the current lack of experimental methods to carry out time-resolved structural studies of membrane proteins at physiological temperatures and under physiological gradients leaves a gigantic blind spot is our mechanistic understanding. We will address this challenge by bringing together our complementary expertise in membrane protein biology, time-resolved structural studies, photochemistry and nano fabrication methods. We will link a set of state-of-the-art technologies to build a technology platform, based on a partitioned microfluidic liquid sample environment, optimised for high-resolution, time-resolved, structural studies of membrane proteins by serial electron diffraction from 2D crystals at room temperature and in the presence of physiologically meaningful membrane gradients for the first time. This will allow us to structurally validate models based on biochemical and computational data, and uncover new possibilities for modulation of function by small molecule therapeutics based on allosteric regulation.

Keywords: time resolved structural biology,membrane protein transporter mechanism,time resolved electron diffraction,liquid cell nanodevices,photoactivateable molecular systems
Study on the influence of nitroxyl (HNO) and nitric oxide (NO) bioactivity on potato defense against pathogens: on the lookout for improving the global food supply. (ONGUARD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Poland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 155793.6
EU funding (EUR): 155793.6
Participants: 2
Project status: TERMINATED

Potato (Solanum tuberosum L.) is one of the world’s most important crops for human consumption, thus it is an integral part of the world's food supply. Poland is the world's 8th largest producer (2nd in the EU), with 9 million tons annually. Potato is susceptible to a wide range of pathogenic organisms, which can cause severe quality and yield losses worldwide. Given the absence of cultivars resistant to pathogens and the immunization of pathogen isolates to successive fungicides, any attempt to understand and strengthen the knowledge of factors related to natural potato immunity is extremely important. In light of this, it is well documented that nitric oxide (•NO) is a key element involved in pathogen recognition as well as activation of local and systemic plant defense signaling activities and pathways. Moreover, the interdisciplinary group proposing this plan recently reported endogenous production of HNO (nitroxyl) in plant tissues (Arabidopsis thaliana) for the first time, and points toward a novel regulatory role. Under physiological conditions, HNO concentration in plant cells is in the nanomolar range. The ubiquitous HNO bioavailability allows it to support or compete with •NO signaling, depending on the local redox environment (shifts with stress or senescence). Finally, we showed that HNO formation is an early reductive stress-related response. Taking all this into account, this proposal will focus on the real-time detection and visualization of simultaneously endogenous HNO and NO in leaves of the important crop plant challenge inoculated with vr/avr Phytophthora infestans, a cause of late blight disease. Moreover, it will be an important issue to answer the question of whether and to what degree the HNO presence in cells modifies the plant's defense responses. The hypothesis is that HNO is generated during potato - P. infestans interaction and can act as a functional signal molecule favoring redox changes towards effective defense responses in potato.

Keywords: potato solanum tuberosum l,nitroxyl hno,nitric oxide no,endogenous gasotransmitter,pathogenic organisms,enhance effective defense responses,real time detection,bioinorganic sensors
The Interplay of Aging, Immune Signaling and Stem Cell Function (immSC-AgingFate)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Portugal
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1998843.0
EU funding (EUR): 1998843.0
Participants: 2
Project status: SIGNED

Adult stem cells (SCs) sustain tissue renewal and repair throughout life. The SC niche is fundamental in the regulation of SC function and an important contributor to SC decline in aging. While alterations in the tissue’s immune environment are emerging as important contributors to impairments found in aged organs, their contribution to SC dysfunction in aging is unknown. The skeletal muscle (SkM) is a paradigmatic model to study age-related loss of repair capacity. Muscle stem cell (MuSC) function during regeneration requires plasticity in transit between states of quiescence, activation and differentiation. MuSC functional impairments in aging result from changes in the extrinsic cues that govern their behavior, but also cell intrinsic alterations, including senescence and defects in lineage commitment. However, we still have a limited understanding of how changes in the environment manifest as SC intrinsic defects. Our previous work indicates that changes in immune signaling are important drivers of MuSC dysfunction and regenerative decline in aging. Here, we propose to identify the contribution of specific immune populations and signals to changes in regenerative capacity and MuSC activity in aging (Aim 1). We hypothesize that the immune environment is an essential regulator of MuSC plasticity and lineage commitment under regenerative pressure, and immune alterations underlie defects in MuSC lineage fidelity in aging. We propose to map the trajectories of MuSCs diverging from the myogenic lineage and uncover the changes in epigenetic landscape that underlie the loss of lineage fidelity associated with immune aging, identifying transcriptional regulators of MuSC fate (Aim 2). The knowledge generated on the mechanisms linking immune aging and MuSC dysfunction will be tested for the conservation in human SkM and will be applied to improve the success of MuSC-based therapies in aging (Aim 3).
Flagship project 2 - MObile radio for RAilway Networks in Europe 2 (FP2-MORANE-2)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Europe's Rail
Action type: Innovation actions
Partnership: EU-RAIL (JU-JTI)
Countries involved: France,Spain,Netherlands,Sweden,Germany,Italy,Hungary,Austria,Belgium,Switzerland,Finland,Norway,Denmark,United Kingdom,Croatia,Poland,Slovenia
Call: EU-RAIL – SNS SYNERGY: DIGITAL & AUTOMATED TESTING AND OPERATIONAL VALIDATION OF THE NEXT EU RAIL COMMUNICATION SYSTEM (HORIZON-ER-JU-2024-01, 2024)
Start date: 2024-12-01
End date: 2027-09-30
Duration (months): 34.0
Total project cost (EUR): 17572123.27
EU funding (EUR): 13499875.24
Participants: 49
Project status: SIGNED

The expected obsolescence of GSM-R and the need to enable digitalisation in train operations has led the European railway sector to set a global plan for the definition of a new radio system, the Future Railway Mobile Communication System (FRMCS), as presented in the EU-Rail System Pillar Report on FRMCS V2 and V3 Scope and Planning (ref. SPG-STG-D-SPG-076-01). A key part of this plan is the delivery by UIC, in the frame of its FRMCS Program, of the FRMCS V3 specifications, also named “FRMCS 1st Edition”, corresponding to the first implementable version of the new system, for their inclusion in a new CCS-TSI in 2027. Starting from the final UIC FRMCS V2 Specifications & V3 target requirements, expected by December 2024 as a result of the ERA EECT process, there will be consequently a need to verify, complete or amend these V2 Specifications & V3 target requirements through a full testing of FRMCS functions and system, leading then to market ready V3 Specifications. This operational testing is precisely the objective of FP2-MORANE-2 (MObile radio for RAilway Networks in Europe). The first step of the testing activities will be achieved in 3 different labs, run by Ericsson, Nokia and Kontron. They will be followed by 5 different field tests, operated on two railway tracks from ADIF, one from DB, one from TRAFIKVERKET and one from PRORAIL. 4 of these lines are conventional, the 5th, in ADIF network, being a high-speed line. The PRORAIL line will welcome a MNO, KPN. The FP2-MORANE-2 project, coordinated by UIC, takes advantage of the participation of 13 European railways, from which 7 will act as associated partners. It regroups the expertise of 13 product manufacturers, all recognised as key players in the FRMCS domain, and finally benefits from the contribution of UNIFE. Conceived as a continuation of all previous FRMCS activities, such as Horizon 2020 5GRAIL prototyping project or EU-Rail R2DATO FRMCS-related work packages, FP2-MORANE-2 will set the way for FRMCS deployments in Europe, as its predecessor MORANE did for GSM-R 20 years ago.

Keywords: frmcs
Digitalised Value Management for Unlocking the potential of the Circular Manufacturing Systems with integrated digital solutions (DiCiM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Czechia,Sweden,Germany,Slovenia,Spain,Türkiye,Hungary,Ireland
Call: Digital tools to support the engineering of a Circular Economy (Made in Europe Partnership) (RIA) (HORIZON-CL4-2022-TWIN-TRANSITION-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 5991891.25
EU funding (EUR): 5991891.25
Participants: 13
Project status: SIGNED

The aim of the current project is to bring about the development of the full demonstrator of DiCiM, a set of integrated digital solutions that makes use of Internet of Things (IoT), Machine Learning (ML) based Artificial Intelligence (AI), Big Data, Image Processing and Augmented Reality (AR) to support different actors of the industrial value chain such as managers, engineers and operators in their decision making and to carry out value recovery activities for circular economy. The integrated digital solutions include an open access digital platform for lifecycle information management and support solutions for value recovery activities. DiCiM project revolves around the value use and value recovery phases of the Circular Value Model (CVM) with the specific data, technology and the management needed to support its implementation. In particular, it focuses on integrated digital solutions to enabling condition monitoring during the use phase, optimizing the reverse logistics, and achieving efficiency and responsiveness in the value recovery activities (i.e. collection, inspection, sorting, disassembly, testing and repairing/refurbishing/remanufacturing/recycling) to enable reuse of products, parts and materials. DiCiM project will demonstrate integrated digital solutions in four use cases in three industrial sectors that represent over two thirds of the European Economy. They include whitegoods (i.e. refrigerators, washing machines), electronics (i.e. printers) and automotive. With important gains such as increase in spare part recovery efficiency by 90% (which means 126 000 labour hours are saved for refrigerator demonstrator) and increase in spare part recovery rate by 20% (about 2920 tons net material saving for washing machines and 6000 tons for automotive). DiCiM digital solutions will boost new circular economy business models based on value recovery activities to sustain and encourage remanufacturing throughout Europe.

Keywords: ai,ar,iot,machine learning,big data,image processing
Pannexin 1 – a novel target for pediatric orphan epilepsy (PANNEXIN)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-10-01
End date: 2026-03-31
Duration (months): 30.0
Total project cost (EUR): 4078906.0
EU funding (EUR): 2499500.0
Participants: 1
Project status: SIGNED

Epilepsy is a group of syndromes with high unmet medical need, especially in children as frequent seizures affect the immature brain and its development. In some orphan syndromes, drug resistance is 70% with dramatic consequences for patients and their families. Novel treatments must prevent the negative effects of seizures, but also minimize off-target effects on brain development and cognitive functions. Our solution is the specific blockade of the activated form of the Pannexin 1 (Panx1) channel using a reformulated form of probenecid: PTI5803. This compound, a first-in-class drug, inhibits seizures preclinically in >80% of cases without hampering cognitive functions. Designed to be adapted to children (from 6 months of age) and to improve the bioavailability, PTI5803 is a highly specific breakthrough product to counteract the pathological activation of Panx1 in patients with an ultra-resistant orphan epilepsy, with the potential to disrupt the market of paediatric epilepsy.
gaLAxies duriNg The Epoch of ReionizatioN (LANTERN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-14
End date: 2026-10-13
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

Our understanding of the first billion years of the Universe, specifically the initial 500 million years, remains quite limited. Until last year (prior to the James Webb Space Telescope launch), only one galaxy had been detected during this period. Since then, the number of candidates from these epochs has surged. This newfound abundance of candidates offers an unprecedented opportunity to delve into a crucial phase known as the epoch of reionization (EoR) marking the Universe's last major gas-phase transition in cosmic history when all the neutral hydrogen gas between galaxies produced by the Big Bang became fully ionized. The actors of this transitional period, the mechanisms underlying its emergence, and the physical properties of galaxies during this period are still mainly unknown. Thus, my research aims to probe the fundamental physics governing these galaxies (particularly their density, luminosity, and stellar mass) and investigate if these properties align with our theoretical framework and hydrodynamic simulations. Preliminary studies, including mine, indicate an excess of bright galaxies compared to the models. I aim to unambiguously quantify the excess of bright galaxies during the EoR, characterize their properties, and investigate the underlying physical phenomena that have driven these galaxies to acquire such properties. In particular, I aim to unveil the emergence of dust during the EoR. The core of this research revolves around leveraging the complementarity between the JWST through the COSMOS-Web program – the largest JWST program designed for detecting these galaxies and for which I am one of the architects - and the Euclid telescope. The outstanding research environment at AIM (host institute) along with my supervisor's expertise offer optimal conditions to enhance my career prospects. Returning to Europe and elevating my profile on national and European platforms through this fellowship align seamlessly with my career's natural progression.

Keywords: high redshift galaxies,epoch of reionization,jwst,uv luminosity function
Mycelium Material Bonding: Molecular Mechanism and Enhancement Strategy (MyBond)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: CLOSED

The development of natural-based materials is crucial to reduce environmental impact and achieve a circular economy. Fungal mycelium has recently achieved significant attention as a new biobased sustainable material. In nature, filamentous fungi colonize lignocellulosic (i.e. plant) substrates such as wood and agriculture waste streams; their elongated mycelium works as a natural glue that binds the substrate together. Taking advantage of this unique binding property, people have developed innovative methods to grow fungal mycelium in different lignocellulosic waste streams resulting in composite products with various forms, densities, and target applications. However, little is known about the fundamentals, especially the essential factors that determine the material properties. This project aims to provide an in-depth understanding of the adhesion of mycelium to the substrate and to use this knowledge to enhance this adhesion to optimize fungal mycelium materials thereby contributing to the EU’s sustainable plan. The project will focus on three different levels: understand filamentous fungi adhesion to lignocellulosic surfaces at the molecular level; improve this adhesion based on the findings; apply this technology to novel fungal mycelium-lignocellulosic-based sustainable materials development. This project will carry out a multidisciplinary study linking molecular and chemical biology to materials science and technology. The transfer of knowledge will benefit both the researcher and the host and further promote mycelium material development. The result of this proposal will be shared with researchers in different disciplines, industrial partners, and the public. It will contribute to EU’s sustainable technology.

Keywords: mycelium adhesion lignocellulosic biomass modification