Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Self Consumption Of Renewable Energy by hybrid Storage systems (SCORES)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies enabling energy-efficient systems and energy-efficient buildings with a low environmental impact
Action type: Research and Innovation actions
Countries involved: Austria,Austria,Germany,Germany,Italy,Italy,France,France,France,Czechia,Netherlands,Portugal
Call: Highly efficient hybrid storage solutions for power and heat in residential buildings and district areas, balancing the supply and demand conditions (H2020-EEB-2017, 2017)
Start date: 2017-11-01
End date: 2022-04-30
Duration (months): 54.0
Total project cost (EUR): 5998598.75
EU funding (EUR): 5998598.75
Participants: 18
Project status: CLOSED

The SCORES project aims is to develop and demonstrate in the field a building energy system including new compact hybrid storage technologies, that optimizes supply, storage and demand of electricity and heat in residential buildings, increasing self-consumption of local renewable energy in residential buildings at the lowest cost. Combination and optimization of multi-energy generation, storage and consumption of local renewable energy (electricity and heat) brings new sources of flexibility to the grid and giving options for tradability and economic benefits, enabling reliable operation with a positive business case in Europe’s building stock. SCORES optimizes self-consumption of renewable energy and defers investments in the energy grid. The SCORES concept is to develop several key-technologies in parallel, ie. second-life Li-ion batteries, compact thermal storage by Phase-Change Materials, high performance hot-water heat pump supplied by hybrid photovoltaic and solar collectors (PVT), Chemical Looping Combustion heat storage (seasonal storage), integrated through a smart Building Energy Management System (BEMS), and to demonstrate them together in a hybrid energy system. Full-scale demonstration will be done with regulatory/normative, economic and market boundaries taken into account. Demonstration of the integrated hybrid energy system will take place in two real buildings representative of different climate and energy system configurations for 3 cases, in Northern Europe with and without a heat grid, and in Middle/Southern Europe without a heat grid. Through smart combination and optimization on the system level SCORES will evaluate technical, economic and environmental benefits being larger than the sum of their parts. The partners in the consortium are the key actors for the required technologies that will be integrated in the project, representing strong industrial partners (OEMs) in the value chain for future exploitation of compact hybrid energy system.

Keywords: hybrid system,chemical looping combustion,heat pump,sensible heat storage,bems,second life electrical batteries
Advanced High-Order Simulation Methods for Industrial Applications (ASIMIA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Belgium,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 1268062.2
EU funding (EUR): 1268062.2
Participants: 5
Project status: CLOSED

The ASIMIA technical objectives aim to improve the predictive capabilities of current aerodynamic simulation tools in industry, based on Computational Fluid Dynamics (CFD), by applying High Order Methods (HOM) instead of current second order approximations. HOM for CFD has a strong potential towards higher reliability of the predicted results, leading to enhanced design process, lower costs and reduced time-to-market of challenging future designs. It is generally considered that HOM could form the next generation of industrial CFD tools, but the competitiveness and adequacy of the HOM approaches for CFD has still to be demonstrated for industrial applications. ASIMIA aims at removing some of the current limitations for high-fidelity industrial applications, leading to a new generation of CFD tools with a high level of efficiency and maturity. NUMECA, an innovative SME acting as CFD and multiphysics software developer is joining with the Center for Numerical Simulation of the School of Aeronautics at Universidad Polytecnica Madrid (UPM) and three Industrial Partners from three different sectors, Aviation with AIRBUS, Car Aerodynamics with McLAREN F1 and Industrial Appliance Industry with DYSON, to lead 5 doctorates towards innovative simulation methods and relevant industrial applications. In addition, ASIMIA will • consolidate a joint PhD training program to foster research in the areas of contemporary fluid dynamics and multiphysics numerical simulation • improve the transfer of knowledge between academia, SME's and industry, establishing a long- term collaboration and dissemination strategy • enhance the preparation of highly trained and skilled young engineers to careers in the high-tech industries • enhance researchers career perspectives in numerical simulation, through the transfer of developed algorithms into industrial CFD codes, learning hereby about the requirements of the software industry in terms of quality, robustness and reliability

Keywords: computational fluid dynamics,high order methods
Enabling institutional change for innovation in European peripheries: from policy to implementation (PeripheRIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: SIGNED

PeripheRIS undertakes research to enable institutional support for innovation policy in European peripheries, with a focus on policy implementation. For more than a decade since the financial crisis, uneven development in Europe has intensified, while the economic, social and political problems faced by peripheral regions have become widely recognized. Yet, under the EU's regional and innovation policies, peripheries are meant to compete with core regions to be economically sustainable - a process which relies on innovation as a key driver of economic growth and prosperity. While it has been suggested for some time that institutions play a role in peripheral development, serious inquiry into institutional aspects of regional innovation systems (RIS) has only recently been sparked. PeripheRIS focuses on the interplay between institutions and actors for the innovation-driven, sustainable transition of peripheral regions in Europe, bridging institutional and entrepreneurial strands of RIS as they unfold in complex institutional-entrepreneurial relations. In peripheries, these can be reduced to key personalities on both sides, and the focus turns to the actors at work within the system. The research aims to uncover mechanisms of institutional support to innovation. From his placement at Eurac Research in Bolzano, Bradley Loewen will develop a case study on the innovation system of Italy's South Tyrol region for comparison to prior cases in Central and Eastern Europe. A mixed methods approach is adopted based on qualitative (interviews) and quantitative (causal process tracing) methods. The cases will support theory-building in the area of evolutionary economic geography, to overcome the need for deep contextualization in future case research, which is a limitation for policy learning. In addition to academic outputs, the project will result in a practical guidebook with recommendations to local and regional governments for supporting innovation in peripheries.

Keywords: regional innovation systems ris,institutions,systems and actors,peripheries,case study,varieties of capitalism,evolutionary economic geography,process tracing,mechanisms of change
‘Development of hypoxia-activated quadruplex DNA binders as potential cancer therapeutics’ (G4Redox)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-04
End date: 2024-01-02
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

Cancer is the second leading cause of death globally. In spite of the great advances in cancer therapy over the past two decades, there is still a pressing need to develop new therapies with reduced side effects caused by conventional therapies. Historically, many chemotherapeutic approaches to treat cancer, have targeted DNA. But targeting genomic DNA has some disadvantages such as undesired side effects due to low selectivity of most chemotherapeutics (e.g. cisplatin and alkylating agents). In this project I aim to address this problem via the development of ‘smart’ compounds that have the following features: (i) target G-quadruplex DNA structures instead of duplex DNA; this non-canonical DNA topologies form transiently during replication and transcription (as well as in the telomeric region) and have been identified as attractive targets for anticancer drugs (ii) developing compounds that are only activated in tumors and not in healthy tissue to achieve this, I have designed pro-drugs that are only activated in the hypoxic (low levels of oxygen) conditions present in tumors and only when activated can target G-quadruplex DNA (iii) my ‘smart’ compounds will not only target G-quadruplex DNA once activated but will release a second drug able to target other cancer molecular targets (e.g. topoisomerase I, COX-2) to cause a cumulative response of the chemotherapeutic agent. I expect to see significant synergism between the different chemotherapeutics released upon activation of the pro-drug. This synergy in the activities is expected to play an important role to overcome drug resistance. The multidisciplinary nature of the project is strong. The proposal includes both way transfer of knowledge between the host group at Imperial College of London and the candidate in new advanced skill sets and techniques. The proposed work will expand my experience, research competencies, and professional networks, enhancing the development of my career as an independent researcher.

Keywords: hypoxia triggered multi action g quadruplex dna binders
Lexical Acquisition Across Languages (LEXICAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-08-31
Duration (months): 72.0
Total project cost (EUR): 1989203.0
EU funding (EUR): 1989203.0
Participants: 1
Project status: CLOSED

Due to the growing volume of textual information available in multiple languages, there is a great demand for Natural Language Processing (NLP) techniques that can automatically process and manage multi-lingual texts, supporting information access and communication in core areas of society (e.g. healthcare, business, science). Many NLP tasks and applications rely on task-specific lexicons (e.g. dictionaries, word classifications) for optimal performance. Recently, automatic acquisition of lexicons from relevant texts has proved a promising, cost-effective alternative to manual lexicography. It has the potential to considerably enhance the viability and portability of NLP technology both within and across languages. However, this approach has been explored for a very small number of resource-rich languages only, leaving the vast majority of worlds’ languages without useful technology. The ambitious goal of this project is to take research in lexical acquisition to the level where it can support multi-lingual NLP, involving also languages for which no parallel language resources (e.g. corpora, knowledge resources) are available. Building on an emerging line of research which uses mainly naturally occurring supervision (connections between languages) to guide cross-lingual NLP, we will develop a radically novel approach to lexical acquisition. This approach will transfer lexical knowledge from one language to another as well as will learn it simultaneously for a diverse set of languages using new methodology based on guiding joint learning and inference with rich knowledge about cross-lingual connections. We not only aim to create next generation lexical acquisition technology but also aim to take cross-lingual NLP a big step toward to the direction where it is no longer dependent on parallel resources. We will use our approach to support fundamental tasks and applications aimed at broadening the global reach of NLP to areas where it is now critically needed.

Keywords: natural language processing,automatic lexical acquisition,lexical resources,lexical semantics,cross lingual nlp,multilingual nlp,language transfer,joint learning and inference,machine learning
Analysis of the Artistic Exchanges in the Medieval Mediterranean between 12th and 15th Centuries through the Geographical Information Systems (GIS): A Critical Review of Centre and Peripheries (ArtMedGIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Portugal
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 160635.6
EU funding (EUR): 160635.6
Participants: 2
Project status: CLOSED

The aim of this research project is to evaluate the artistic exchanges in the Mediterranean during the late Middle Ages through the Geographical Information Systems (GIS). The start point is the selection of certain elements of the Islamic art, developed by the Almoravids in the 12th century. It is assumed that Almoravid arts and architecture were not isolated and can be related to other Mediterranean artistic manifestations due to commercial, political and cultural relations. In this context, the objectives of the project are: to measure the presence of the pre-selected elements in the main artistic manifestations of the Islamic and Christian Mediterranean countries in the late Middle Ages, to apply the new method based on the GIS, through the creation of three databases for studying the exchanges between the main Mediterranean artistic manifestations and Almoravid art, to assess the relation of religion and power with the artistic productions of the Islamic countries in the Mediterranean frame and to review the concepts of centre and peripheries regarding the artistic production in the Mediterranean context. To achieve the objectives the fellow will extract the study data from the historiography, Arab and Latin written sources related to this period, and the artistic funds of the main museum collections with medieval Mediterranean pieces. The results will be included in a database, a blog and several publications, which will be available for the scientific community and the general public. The importance of this project lies in the revision of concepts, the improvement of the knowledge of societies that lived simultaneously in a given territory through the study of their culture and thought, and the introduction of an innovative method for the Art History research, based on the GIS. All these factors will become Europe a leading intermediary power between East and West, thanks to the comprehension of history, religion and culture of Islamic Mediterranean countries

Keywords: artistic elements,almoravid art,12th 15th century,mediterranean,geographical information systems gis
Comparative INsect CHRONobiology (CINCHRON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Spain,Italy,Israel,Italy,Poland,France,Czechia,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-06-01
End date: 2022-11-30
Duration (months): 54.0
Total project cost (EUR): 3809005.92
EU funding (EUR): 3809005.92
Participants: 14
Project status: CLOSED

Chronobiology is the study of biological rhythms. The best understood cycles are those with circadian 24 hour periods that modulate the temporal dynamics of physiology and behaviour of all higher organisms. Four model organisms have been widely used to study the underlying molecular biology of endogenous circadian clocks, Cyanobacteria, the fungus Neurospora, the fruitfly Drosophila, and the mouse. Insect clocks, both circadian and seasonal, are vital for adaptation to the environment and recent global patterns of climate change mean that insect pests and vectors of disease are expanding their ranges into Europe. Consequently there is an urgent need to study the circadian clocks of these insects and how they synchronise to the environment. CINCHRON will create an integrated European centre of excellence for the research training of ESRs in the emerging multidisciplinary field of Comparative INsect CHRONobiology. CINCHRON will bring together molecular neurogeneticists working predominantly with Drosophila, and comparative biologists who study circadian and seasonal clocks of non-model insects of economic importance. These researchers have different approaches so we will harness their different skills for mutual benefit via the integrated training of their ESRs in association with industrial partners. This will be done by high level interactions between university and industry, as well as interactions among laboratories with different areas of expertise, thereby connecting the different sectors (academic and commercial) as well as different disciplines. The goal is to seed-corn the next generation of researchers with highly trained, flexible workers in cutting edge technological methods and complementary generic skills that will support European academic, academic-related and industrial institutions. CINCHRON will therefore contribute to the integration and cohesion of future European research efforts in solving pure and applied biological problem.

Keywords: insects,circadian,seasonal,clock,genetics,synchronize,environment
Dissection of Bioenergetic Plasticity of Tumors (ONco-Energetics_OFF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-08-31
Duration (months): 66.0
Total project cost (EUR): 1499875.0
EU funding (EUR): 1499875.0
Participants: 1
Project status: SIGNED

Tumors reprogram their metabolism to fuel rapid growth. Glycolysis and oxidative phosphorylation “OXPHOS” are the main energy-producing pathways. For decades, metabolic reprogramming of tumors was perceived as only increased glycolysis (Warburg effect). This dogma has recently been revised as we started to realize the importance of OXPHOS in tumor metabolism. We are now entering a new era as metabolomics studies show that tumor metabolism is more heterogeneous than initially assumed. In the preparatory phase of this proposal, using an integrated transcriptional and metabolic profiling, a panel of cancer cell lines was first classified according to the bioenergetic pathway they predominantly utilize (glycolysis or OXPHOS). Second, the response of glycolytic and OXPHOS-dependent cells to the inhibition of their wired bioenergetic program was assessed. My findings show that regardless of their dependency at baseline, cancer cells can be collectively categorized according to their adaptability into “bioenergetically-committed” to one of the two pathways or “bioenergetically-plastic” cells which are able to switch from one to the other upon metabolic challenges. This proposal uses an integrated system approach to dissect the molecular signature, regulation and implications of bioenergetic plasticity. We will answer three key questions: 1-Why some cancer cells are bioenergetically-plastic while others are committed? What are the differences in metabolic machineries and oncogenic switches between both? 2-How heterogeneous tumor cell subpopulations are in terms of bioenergetic plasticity? Does metabolic crosstalk contribute to bioenergetic plasticity of tumors? 3-What are the implications of bioenergetic plasticity in drug resistance and metastasis and finally how to design approaches to target this plasticity? Only handful drugs targeting tumor energetics have made it to clinical use. ONco-Energetics_OFF has a realistic and immediate translational potential.

Keywords: tumor metabolism,bioenergetics,plasticity,glycolysis,oxidative phosphorylation,mitochondrial respiration,oxphos,mcl 1,mtorc1,pp2a,metformin,fasting,drug resistance,metastasis