Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
WIDER AND ENHANCED VERIFICATION FOR YOU (WeVerify)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Belgium,Bulgaria,Greece,Greece,France,United Kingdom
Call: Future Hyper-connected Sociality (H2020-ICT-2018-2, 2018)
Start date: 2018-12-01
End date: 2021-11-30
Duration (months): 36.0
Total project cost (EUR): 2931000.0
EU funding (EUR): 2499450.0
Participants: 9
Project status: CLOSED

Online disinformation and fake media content have emerged as a serious threat to democracy, economy and society. Content verification is currently far from trivial, even for experienced journalists, human rights activists or media literacy scholars. Moreover, recent advances in artificial intelligence (deep learning) have enabled the creation of intelligent bots and highly realistic synthetic multimedia content. Consequently, it is extremely challenging for citizens and journalists to assess the credibility of online content, and to navigate the highly complex online information landscapes. WeVerify aims to address the complex content verification challenges through a participatory verification approach, open source algorithms, low-overhead human-in-the-loop machine learning and intuitive visualizations. Social media and web content will be analysed and contextualised within the broader online ecosystem, in order to expose fabricated content, through cross-modal content verification, social network analysis, micro-targeted debunking and a blockchain-based public database of known fakes. A key outcome will be the WeVerify platform for collaborative, decentralised content verification, tracking, and debunking. The platform will be open source to engage communities and citizen journalists alongside newsroom and freelance journalists. To enable low-overhead integration with in-house content management systems and support more advanced newsroom needs, a premium version of the platform will also be offered. It will be furthermore supplemented by a digital companion to assist with verification tasks. Results will be validated by professional journalists and debunking specialists from project partners (DW, AFP, DisinfoLab), external participants (e.g. members of the First Draft News network), the community of more than 2,700 users of the InVID verification plugin, and by media literacy, human rights and emergency response organisations.

Keywords: disinformation,misinformation,fake news database,debunking,multi modal content verification,social media,network analysis,blockchain,digital companion,factchecking,micro targeting
Adaptive immunity in prokaryotes: how Bacteria do not forgive and do not forget their enemies (REMEMBER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Netherlands,Netherlands
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-06-01
End date: 2020-05-31
Duration (months): 60.0
Total project cost (EUR): 1499183.75
EU funding (EUR): 1373296.84
Participants: 2
Project status: CLOSED

Microbes in natural ecosystems are under constant evolutionary pressure from viruses. To survive in this hostile environment microbes have evolved an adaptive immune system called CRISPR-Cas. The immune system is based on incorporation of invader DNA sequences in a memory locus (CRISPR), the formation of guide RNAs from this locus, and the degradation of invading target DNA using CRISPR RNA-guided protein complexes. Invaders escape immunity by making point mutations in the targeted region of their DNA, but hosts quickly restore immunity by integrating new memory sequences against the same invader in a process called priming. Recently, I have made the remarkable discovery that hosts mount a primed immune response even when facing heavily mutated invaders. This implies that the memory of the CRISPR-Cas system not only functions in the short term against relatively recent threats, but also remembers a range of revisiting old foes in the long term, providing a huge evolutionary benefit for the host in the arms race with their invaders. This proposal sets out to determine the mechanism of the enigmatic process of primed memory formation against heavily mutated invaders. Using a combination of genetic, biochemical and structural approaches, including state-of-the-art single molecule imaging of CRISPR immunity in living Escherichia coli cells, I will investigate the driving hypothesis that perfectly matching and degenerate targets are differentially recognized, and trigger either target DNA degradation or priming. Moreover, I will test the supposition that degenerate priming is a universal phenomenon among different CRISPR-Cas types. If this is the case, degenerate priming will impair the use of viruses as therapeutic agents to treat antibiotic resistant bacterial infections. To prevent CRISPR resistance I propose to screen for organic molecules that inhibit the formation of CRISPR resistance. These molecules can be co-administered with viruses to potentiate treatments.

Keywords: crispr,bacteria,viruses,immunity,small rnas
INNOVATIVE LASER MACHINE FOR INDUSTRIAL ENGRAVING AND 3D TEXTURING (INFINITE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-01-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Created 15 years ago, the innovative Italian company ML Engraving Srl is one of the leaders in laser engraving and texturing on moulds/dies and parts for automotive and consumer goods industries in one of the most industrialised regions in Europe, Lombardia. ML Engraving is also part of the partner´s alliance “Cactooos, The Engraving Network” , which gathers the best companies – ML Engraving, DS4 and 2 other Italian SMEs (Jockoo and NovaTex) – specialized in services connected to the creation and engraving and texturing on moulds. With INFINITE project, they are developing an innovative laser machine for high precision engraving and 3D surface texturing, fully adapted to these industries in terms of design requirements, productivity, repeatability, easy operability & price. This new technology will allow ML Engraving to consolidate its position in the laser engraving/texturing services (+32% services in 5 years) while extending its business – in partnership with DS4 – as laser machine supplier for these markets and other production lines industries in Europe and Worldwide (€25 million accumulated sales for 2017-2021).

Keywords: automotive,laser,engraving,polymer
Integral p-adic Hodge Theory and p-adic Vanishing Cycles (IPAHOT-PVC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-03
End date: 2018-10-02
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

The proposed project concerns p-adic Hodge Theory, a major area of arithmetic algebraic geometry; it owes its existence to the 1968 observation of John Tate that the well-known Hodge decomposition of the singular cohomology of a complex manifold should have a p-adic analogue, in which the singular cohomology is replaced by the p-adic etale cohomology. There are currently two distinct approaches to the study of this Hodge-Tate decomposition. The first, developed mainly by Bloch, Kato, and Tsuji, uses algebraic K-theory, syntomic complexes, and p-adic vanishing cycles, while the second, more in line with Tate's original ideas, was developed by Faltings using his almost mathematics and purity theorems. The project will resolve a number of outstanding open problems in the field, including the relation between these distinct methods, the resolution of a 1983 conjecture of Bloch on vanishing cycles, and the development of integral results keeping track of p-torsion. It is a particularly timely moment to carry out such a project as the ER has recently developed a new integral p-adic cohomology theory with Bhatt and Scholze, while the Supervisor has recently put Faltings' machinery on a rigorous base in an extended joint work with Gros. The conjunction of the complementary backgrounds of the ER and Supervisor will be central to the project. Specifically, the ER's recent work with Bhatt and Scholze, as well as his expertise in K-theory, topological cyclic homology, de Rham--Witt methods, etc., will be merged with the Supervisor's detailed understanding of the aforementioned works of Bloch, Kato, Tsuji, and Faltings. The theories of perfectoid spaces and pro-etale cohomology, as introduced by Scholze, will play a fundamental role.

Keywords: p adic hodge theory,vanishing cycles,k theory
Neurophenomenology of Mental Imagery (NeuPheMi)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-22
End date: 2018-03-21
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The NeuPheMi project presents a novel approach in the neuroscientific study of mental imagery. Mechanisms of mental imagery are not yet well understood and while traditional approaches investigated their neural correlates based mostly on problem-solving tasks, NeuPheMi proposes to shed the light on the neural correlates of experiencing mental imagery. By taking into account the subjective experience and using electroencephalography and brain stimulation techniques to investigate the dynamic of neuronal activity during mental imagery in an original neurophenomenological approach, NeuPheMi is expected to bring a better understanding of the neuronal basis of mental imagery and extend our comprehension of human consciousness. Conjointly investigating the subjective experience and cerebral activity during mental imagery is a considerable research challenge, with tremendous benefits to both applied and basic science – directly in line with the European research priorities, as underlined in the Horizon2020 Future and Emerging Technologies initiative Knowing, doing and being: cognition beyond problem solving.

Keywords: electroencephalography,brain stimulation,phenomenal data,mental imagery
ElectroRheological fluid based eXOSkeleton devices for physical upper limb rehabilitation (ERXOS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2016-04-01
End date: 2016-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The main objectives of the ERXOS innovation project are to develop ready-to-market innovative, modular, light weight, low cost, intrinsically safe, portable, semi-active exoskeleton devices to be used for the optimization and easy personalization of the rehabilitation treatment for upper limb. The above objectives will be pursued through the uptake of a class of Smart Materials called Electrorheological Fluids (ERFs), whose principal exploited characteristic is the change of their rheological capabilities to provide a unique tunable mechanical resistance opposed to motion when an electric field is applied. The proposed product key marketing features, enabled by the ERFs technology, will be: low-cost to allow the use of robot-assisted therapy in rehab centres and also in nursing houses, private physiotherapists centres, specialized fitness centres for elderly people (e.g. Adaptive Physical Activity-APA); intrinsically safe (no presence of active power actuators) allowing an easier Standard Compliance certification procedure and decreasing time to market; intuitive to reduce set-up time and to allow a simple use without supervision; adaptable in terms of possible use of people with different sizes and needs; modular to be split in different sub-systems to allow, as an example, separate rehab of shoulder, elbow, wrist; goal-oriented (e.g. combined with serious game techniques/virtual reality systems).The ERXOS devices have the target to enhance the quality of rehabilitation services at low-cost and for all. The feasibility study of the ERXOS Project will be dedicated to assess the complete viability of the proposed products with the main aim to reach the market in a 3 years period. To this extent a detailed business plan will be produced at the end of PHASE I including risk assessment, market analysis and detailed market strategy.

Keywords: electrorheological fluid,robot assisted rehabilitation,exoskeleton,upper limb rehabilitation
Energy efficient and environmentally friendly multi-fuel power system with CHP capability, for stand-alone applications. (PROMETHEUS-5)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Greece
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The primary objective of the Prometheus-5 project is the field testing, standardization and industrialization of a highly innovative, energy efficient and environmentally friendly power production system, mainly for decentralized power generation. The device is able to convert the fuel (LPG/Natural Gas/Biogas) into electrical and thermal power, with intermediate production of hydrogen, by means of a Proton Exchange Membrane (PEM) fuel cell. Hydrogen is produced on site, via the reformation of the fuel, and feeds the PEM fuel cell, resulting in the production of electrical power. The nominal capacity of the power system is 5 kWe, while, in the case of CHP, an additional 7kW of thermal energy is produced. Regarding its electrical efficiency, it is greater than 35%, while the total efficiency, when thermal power is included, exceeds 85%. The proposed innovative and efficient technologies address major EU and global challenges, dealing with both environmental and efficiency issues and they are in accordance with the Roadmap for moving toward a low-carbon economy in 2050. The product targets decentralized power production, where numerous applications have been identified. The sectors that will mainly be focused on are the followings: telecommunications, biogas production plants, transportation, marine, households, hospitals, etc. Currently, this market segment is served by diesel or gasoline generators which rely on mature and relatively low cost technology. However, the proposed system has electrical efficiency twice that of the conventional technology and less than half of its emissions. Also, it presents lower operational and maintenance costs and noise-free and reliable operation. The main objective of phase 1 of the project is to conduct a feasibility study evaluating all aspects of the commercial application of the developed product. This will include conduction of market and techno-economic studies, SWOT analysis, exploration of market and product strategies, etc

Keywords: hydrogen production,fuel cells,power production,out of grid applications
The Development of a »New« Planocentric Gearbox with a Closed Cage and S-gear Tooth Flank (S-Gearbox)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Slovenia
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2015-06-01
End date: 2015-10-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The planocentric gearboxes are complex mechanical devices with precisely manufactured components, particularly suitable for automation and mechatronic subsystems. On the market, several solutions are available, none of which cope with the main disadvantages of the technology. The most common drawbacks of these solutions start with a single cage design structure which suffers in looseness and unfavourable shaft loading. A precise manufacturing and assembly is of utmost importance in the case of the cycloidal planocentric gearboxes, so manufacturing costs could be increased. Moreover the gear ratio is limited. Additional problems, in lantern gears, are sliding and efficiency. All in all, current gearboxes are not fully optimised and present a high lifecycle impact on the environment. S-Gearbox project is dedicated to eliminating the common drawbacks and replacing several metal parts with plastic material, increasing the overall reliability and recyclability of the gearbox. Our goal is to develop a new planetary gearbox as small and as lightweight as possible, with low hysteresis for accurate positioning, high torsional stiffness, low inertia, high efficiency, overload capacity, lifetime lubrication, no maintenance. Developed and optimized S-gearbox will have tremendous potential to be used for different applications primarily in automotive and aerospace industry but also many other industries, such as: wind turbines industry, household appliances, mechatronic devices, industrial equipment and medical equipment. The main aims of our proposal at this stage of development of the technology, are to finalise the analysis of all the remaining technological risks associated with our innovation and proving our solution in an operational environment in automotive or airspace industries, to assess the size of potential market, outline a full product development, IP protection and marketing strategy and to assess the environmental burden.

Keywords: gear box,tooth flank,innovation,automotive industry,wind turbines industry,plastic,robotics
Competitive assembly dynamics of the DCC receptor with its guidance cues integrates signals for cellular steering (GUIDESIGINT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-01
End date: 2019-01-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Secreted proteins and their receptors underlie the communication networks of multicellular organisms and guide the proper organization of developing tissue. An essential process involves the human transmembrane receptor and signal integration hub, Deleted in Colorectal Cancer (DCC). Emerging evidence indicates that the netrin and draxin guidance cues are secreted by neighboring cells and form competitive and complex multivalent interactions with DCC. The DCC receptor thus integrates multiple inputs (netrin and draxin) to elicit the appropriate physiological response (cell migration towards or away from the source of netrin or draxin, or even programmed cell death), resulting in proper connectivity of neurons in the brain and of endothelial cells in blood vessel networks, or their misprogramming in tumorigenesis. Our knowledge of this medically important signaling pathway is now poised for translation to an integrated systems mechanism across biological scale. This research action will address the challenge by experimentally determining the competitive and multivalent assemblies formed among netrin, draxin and DCC as a biophysical basis for signal integration. These binding events will then be computationally simulated to examine their dynamic partner exchange and polarized orientation of assemblies in the membrane that are dependent on their distance from the netrin and draxin sources. Experiments and simulations of competitive binding and assembly will be further complemented and validated by assaying the distance-dependent turning response of living axons placed between netrin and draxin-soaked beads. Together, these approaches will describe the competitive assembly dynamics of signaling and will provide unprecedented mechanistic insights into cellular communication and organization, thereby targeting efforts for therapeutic intervention.