Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Illuminating neural microcircuitry underlying flicker resonance in the visual cortex (ResonanceCircuits)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-12-15
End date: 2022-12-14
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

Almost 200 years ago, Jan Purkinje examined the visual illusions induced by flickering light. Since then, scientists, clinicians, and artists have been fascinated by the effects of flicker on brain rhythms. When entrained with rhythmic light of ~10, ~20, ~40 Hz, visual cortex responds more strongly, or resonates. In the visual and cognitive neurosciences, resonance flicker is used to study perception and attention; in clinical domain, aberrant resonance responses to flicker are used as a diagnostic tool and potential treatment. However, the neural mechanisms by which flicker engages resonant properties of local cortical circuits and entrains brain rhythms at the level they are generated remain unknown. Over the past decade, this level became accessible to neuroscientists due to the rapid development of new neurobiological tools such as cell-type-specific optical stimulation (optogenetics). In this project, using recordings that span multiple spatial scales (from neurons and local field potentials across cortical layers to EEG), I will characterize the neural mechanisms by which flicker stimuli engage resonant properties of brain rhythms. I will use optogenetic tools to identify and manipulate genetically targeted cell types, and will combine it with simultaneous EEG and high-density laminar recordings in primary visual cortex of awake mice. I will determine the laminar profile of neural activity underlying flicker resonance observed at the EEG level (Study 1). By recording from distinct GABAergic interneuron classes and optogenetically silencing them, I will test the novel hypothesis that distinct classes of interneurons mediate flicker resonance to low (theta, alpha) and high (beta, gamma) frequencies (Study 2). This research will allow me to uncover the neurophysiological basis of resonance responses to flicker in unprecedented detail, and provide means to exploit the untapped potential of flicker as a tool to study and modulate brain rhythms in a targeted way.

Keywords: flicker,resonance,steady state visual evoked potentials,optogenetics,multiscale
Performance Improvement for Vehicles on Track (PIVOT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Spain,Austria,Austria,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Spain,Italy,Austria,Sweden,Sweden,France,France,United Kingdom,United Kingdom,United Kingdom,Portugal
Call: Development of new technological concepts towards the next generation of rolling stock, applied to major subsystems such as Carbody, Running Gear, Brakes, Doors and Modular interiors (H2020-S2RJU-CFM-2017, 2017)
Start date: 2017-10-01
End date: 2019-12-31
Duration (months): 27.0
Total project cost (EUR): 7746802.22
EU funding (EUR): 7746802.22
Participants: 33
Project status: CLOSED

PIVOT takes the Roll2Rail Lighthouse project and addresses mechanical systems within rail vehicles: Carbodies, Running Gear, Brakes, Entry Systems and Interiors including the Cab. With seven technical WPs, it uses a system engineering approach, giving innovations tangible context considering real interface constraints. It includes specific, trackable, relevant, achievable and motivating quick wins which focus attention and drive home innovation. • WP1 explores the materials, joining techniques and manufacturing for innovative carbodies. It seeks to develop a risk-assessed demonstrator specification. • WP2 develops conceptual carbody components for alternative materials. It includes structural/non-structural assessments, FMECA and a sustainability assessment of facets like reparability and recyclability. • WP3 focusses on smart solutions for running gear considering functions such as health monitoring and active suspension systems. These include new sensor system architecture and affordable hardware providing sufficient reliability and robustness. • WP4 addresses running gear performance more generally. It seeks to develop a common technical specification, to innovatively use both new and existing materials and to scope the authorisation demands arising. • WP5 progresses innovations such as electronics with high Safety Integrity Levels, eddy current brakes, new friction pairs, electro mechanical brake solutions and virtual certification. • WP6 covers entry systems with themes including gap fillers, door entry surveillance, solutions for Persons of Reduced Mobility and performance improvement through mass reduction, improved insulation and higher acoustic attenuation. • WP7 deals with modular interiors both for passenger spaces and cabs and aims make vehicle reconfiguration easier. Topics include flexible systems for adjusting tables, seat, luggage racks and the general décor, and ‘plug and play’ systems within the driver’s cab.

Keywords: rail vehicle mechanical engineering solutions
Mine Kafon Drone: An Unmanned Airborne Demining System (MKD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2020-01-01
End date: 2020-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

There are more than 100 million active landmines throughout the world. These explosive devices not only kill 10 innocent civilians every day, but they breed fear and helplessness in the minds of millions of people around the world. Speaking about the landmine issue, Paul McCartney of The Beatles said: "When a war is over I think it's a cowardly thing to leave the war behind you in minefields that hit women and children and the most vulnerable. Imagine the war is finished and you go to work and there are snipers shooting at you. Imagine taking your kids to the beach and you find that the beach is blowing up beneath you. Like there's nowhere safe." Using current technologies, detecting and clearing all landmines across the entire world would not be accomplished within our lifetime. These established processes, such as manual or animal-based discovery, are slow, dangerous and expensive. These drawbacks often mean that no demining efforts are even started in the first place. Massoud and Mahmud Hassani, the founders of Mine Kafon, grew up on the edge of Kabul, in Afghanistan. They experienced the horrors of landmines from an early age. These experiences fueled the brothers to found Hassani Design BV and develop the Mine Kafon Drone (MKD) system. Using unmanned aerial vehicles (UAVs), the MKD offers a disruptive solution to landmine detection, providing a reliable and safe system that maps entire areas and scans them centimetre by centimere. Moreover, it does so faster, cheaper and more efficient than current technologies, without putting any human or animal life at risk. The following proposal explores MKD's potential by examining its technical feasibility (problem-solution fit) and its commercial feasibility (product-market fit). With an increasing amount of money allocated for humanitarian demining, and with the drone market undergoing an exponential rise, the time to solve this long overdue problem is now. Help us make the world a safer, more hopeful place!

Keywords: landmine mapping,landmine detection,unmanned demining system,cloud based platform,landmine free world,disruptive innovation,drone technology,humanitarian aid
CIPHER: Hip Hop Interpellation (Le Conseil International pour Hip Hop et Recherche / The International Council for Hip Hop Studies) (CIPHER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Ireland
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-08-01
End date: 2024-07-31
Duration (months): 60.0
Total project cost (EUR): 1990526.25
EU funding (EUR): 1990526.25
Participants: 1
Project status: SIGNED

CIPHER will launch the global research initiative, Hip Hop Interpellation, pilot a new semantic digital/ethnographic web methodology, and codify the emergent discipline of global hip hop studies. It addresses the central question: why has this highly localized and authenticizing African American music translated so easily to far-flung communities and contexts around the globe? Through this specific question the project attempts to understand the foundational and broadly transferable question: how are globalization and localization related? To answer these questions CIPHER posits the Hip Hop Interpellation thesis, that hip hop spreads not as a copy of an African American original, but, through its performance of knowledge, emerges as an always already constituent part of local knowledge and practice. The theorization thus moves beyond the “hailing practices” described by Althusser’s theory of interpellation—the discursive webs that coerce ideological incorporation—to describing an interpolation that locates other histories within and through hip hop’s performed knowledges. CIPHER’s semantic web methodology tests this thesis, tracking how hip hop memes—slogans, anthems, and icons—are simultaneously produced by people and produce people. This research clears the conceptual impasse of structural “cultural imperialism” vs. agentic “cultural appropriation” debates and instrumentalizes the methodological distance between ethnographic specificity and big data generality. It does so by creating a feedback loop between digital humanities methods (crowd sourcing, semantic tagging, computational stylometry) and ethnographic fieldwork techniques (interviews, musical analysis, participant observation). The result will be an iterative map of Hip Hop Interpellation/Interpolation created by stakeholders that is transformational of our understanding of culture and/as cultural production and transferable to pressing questions about globalization and l’exception culturelle.

Keywords: global hip hop,glocalization,big data,ethnography
Combinatorial Construction (CC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-01-01
End date: 2021-06-30
Duration (months): 66.0
Total project cost (EUR): 1706729.0
EU funding (EUR): 1706729.0
Participants: 1
Project status: CLOSED

Combinatorial Construction is a mathematical challenge with many applications. Examples include the construction of networks that are very sparse but highly connected, or codes that can correct many transmission errors with little overhead in communication costs. For a general class of combinatorial objects, and some desirable property, the fundamental question in Combinatorial Construction is to demonstrate the existence of an object with the property, preferably via an explicit algorithmic construction. Thus it is ubiquitous in Computer Science, including applications to expanders, sorting networks, distributed communication, data storage, codes, cryptography and derandomisation. In popular culture it appears as the unsolved `lottery problem' of determining the minimum number of tickets that guarantee a prize. In a recent preprint I prove the Existence Conjecture for combinatorial designs, via a new method of Randomised Algebraic Constructions; this result has already attracted considerable attention in the mathematical community. The significance is not only in the solution of a problem posed by Steiner in 1852, but also in the discovery of a powerful new method, that promises to have many further applications in Combinatorics, and more widely in Mathematics and Theoretical Computer Science. I am now poised to resolve many other problems of combinatorial construction.
Flight plan artificial intelligence assistant (FlightAI)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Italy,Switzerland
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-4, 2020)
Start date: 2021-09-01
End date: 2023-05-31
Duration (months): 21.0
Total project cost (EUR): 133291.43
EU funding (EUR): 100000.0
Participants: 4
Project status: SIGNED

Drones in Europe are a rapidly developing sector with enterprises increasingly using drones for their business and the EU Legislator giving EASA rulemaking responsibility for civil drones of any mass. The common rules have been developed and will be enforced from January 2021. The performance of flight operations requires the compilation of a safety risk assessment document, in particular, the SORA (Specific Operations Risk Assessment) established for drone operations and endorsed by EASA. Compiling this assessment is expertise intensive and time-consuming. Currently, EUSC supports this operation with a web service called SAMWISE that, however, still requires the manual gathering of a large amount of information and the satisfaction of several constraints. The project aims to integrate into the web-solution built by EUSC the Artificial Intelligence (AI) technology generated by the FET-OPEN GOAL-Robots project, allowing the search of solutions in highly-nonlinear search spaces. The new technology from GOAL-Robots will support the semi-autonomous search of a solution to formulate flight plans based on an interactive interface, that meets the user’s requirements (flight start/arrival points, drone available, pilot licences, etc.), the SORA requirements, and the GIS characteristics of the involved overflown territory/airspace. The project will accomplish a systematic validation of the integrated system by testing the acceptability and usability of the proposed technology by selected stakeholders through the wide stakeholder network of the consortium. Moreover, business case refinement and focused dissemination activities will pave the way to the commercialisation of the produced service within the European drone market.

Keywords: service for drone markets,drone flight regulations,easa,sora specific operations risk assessment,drone flight plan formulation,artificial intelligence novelty enhanced search algorithms
STING immune activation and regulation by phosphatidylinositol 4-phosphate-associated components (STARPAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-10-03
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: SIGNED

The immune response to cytosolic DNA is crucial for preventing tumour formation and virus infection. This response critically depends on the cGAS-STING pathway, which detects cytosolic self-DNA present in tumour cells and viral DNA. STING can also detect cytosolic self-DNA induced by upon RNA virus infections, and numerous RNA viruses have evolved strategies to disable STING. STING activation is a complex process that requires various post-translational modifications, leading to STING trafficking and activation at the Golgi apparatus. STING activation induces the transcription of genes that promote immune cell recruitment. Aberrant STING regulation may lead to virus infections, inflammatory disorders, and tumour formation. Many of the regulators involved in STING activation are unknown. To identify host factors regulating STING activity, I recently performed a genome-wide CRISPRi screen (Luteijn et al, 2019, Nature). I found many novel genes involved in STING activation, including the Golgi protein ACBD3. This protein localizes the phospholipid phosphatidylinositol 4-phosohate (PI4P) to the Golgi membrane by recruiting the PI4P kinase PI4KB. My preliminary work revealed that STING activation in the Golgi critically depends on ACBD3 and PI4P. Remarkably, ACBD3 and other PI4P-associated factors are also targeted during infection by certain RNA viruses. It is completely unknown how ACBD3 and PI4P distribution affect STING activity, and if PI4P hijacking by RNA viruses modifies the STING-induced immune response. This project has 3 main objectives: 1. Define the role of ACBD3 and PI4KB expression and function on STING activation 2. Identify and target regulators of PI4P biology to increase STING activity 3. Define the role of PI4P hijacking by RNA viruses on STING immune evasion Understanding how ACBD3 and other PI4P-associated factors regulate STING will lead to the identification of novel therapeutic targets to combat tumours, virus infections, and inflammation.

Keywords: sting,phosphatidylinositol 4 phosohate,membrane trafficking
Twinning in non-Gaussian Physics for Quantum Technology (NONGAUSS)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: France,Czechia,Denmark
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 899625.0
EU funding (EUR): 899625.0
Participants: 3
Project status: SIGNED

The NONGAUSS project aims at enhancing the research profile of the Department of Optics of Palacky University (UP) in Olomouc in modern quantum science, intensifying networking with top Quantum Technology laboratories, broadening the applicability of theoretical non-Gaussian quantum physics in experiments, disseminate outcomes to quantum community and communicate about Quantum Technology to general public and young generation. Through the intensified individual training of Early Stage Researchers (ESRs), postdocs and also academic staff in the modern experimental tools and methods of quantum technology (see Section 1.2 and WP1), not yet available in the Czech Republic, NONGAUSS will eliminate the main bottleneck of the expanding theory group in Olomouc and increase its impact within EU. The project partners, excellent foreign experimental teams at the Laboratoire Kastler Brossel, Sorbonne Université (SU) in Paris and the Danish Technical University (DTU) in Lyngby, will provide the required complementary expertise and in close collaboration with UP form a clear scientific strategy to significantly strengthen the tools and methods of non-Gaussian quantum technology (see Section 1.3). These complementary laboratories belonging to a network of EU quantum technology labs will cover the full spectrum of modern optical, atomic, mechanical and solid-state experiments in quantum technology. The NONGAUSS project will combine this training process (WP1) with extensive networking, workshops, summer schools (WP2), expert visits and presentations at international conferences and colloquia (WP3) with knowledge transfer for management & administration of research (WP1), dissemination to broad quantum community and communication to general public focused to young generation and policymakers (WP4). The project will contribute to new experimental proposals, prepare publicly available reviews, and stimulate submission of new EU research grant applications and fellowships.

Keywords: quantum optics,quantum technology,quantum information,quantum optomechanics,quantum,nanophysics
Interdisciplinary Cybercrime Project (iCrime)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 1499966.0
EU funding (EUR): 1499966.0
Participants: 1
Project status: SIGNED

The Interdisciplinary Cybercrime Project (iCrime) is an innovative research program incorporating expertise from criminology and computer science to develop and evaluate cybercrime responses. iCrime consists of four major interconnected components to research cybercrime using the offender, the crime type, the place (such as online black markets), and the response as discrete units of analysis. The pathways of cybercrime offenders will be explored, such as how they begin offending, and why they stop, including similarities and differences across populations. The steps and skills required to successfully undertake complex forms of cybercrime will be mapped out. We will also analyse the social dynamics and economies surrounding cybercrime markets and forums, and how these evolve. We will use the findings from the first three components to inform situational and social crime prevention initiatives. In the fourth component, we will use robust experimental designs to evaluate the effects of these interventions, measuring their impact on crime reduction, as well as how offenders and their methods adapt and displace as a result. We will work with law enforcement and industry to build evaluation into their implementation strategy. We will also use natural experiments to measure the effects of interventions ‘in the wild’. The project is flexible in nature, enabling us to respond to new cybercrime issues as they emerge. Cybercrime offenders are innovative and change monetising techniques rapidly. This approach will be valuable for quickly understanding cybercrime techniques. Within iCrime, we will develop tools to identify and measure criminal infrastructure at scale. Difficult challenges will be tackled by using and developing unique datasets, and designing novel methodologies. This is particularly important as cybercrime changes dynamically. We will be at the forefront of new developments as they arise. Overall, our approach will be evaluative, critical, and data driven.

Keywords: cybercrime,criminology