Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Regions’ Alliances for Interconnected Startup Ecosystems (RAISE)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Belgium,Spain,Ireland
Call: Preparatory action for setting up joint programmes among innovation ecosystems actors (HORIZON-EIE-2021-CONNECT-01, 2021)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 498625.0
EU funding (EUR): 498625.0
Participants: 5
Project status: CLOSED

The main goal of RAISE is to contribute to the development of a new and sustainable integrated support framework to foster startup growth and scale-up within and across Europe in all its dimensions, from initial funding, research support to public incentives and internationalization. This will result in promoting competitive business models, unconventional collaborations and solutions from all, in all over Europe, and contributing to the establishment of a true EU startup ecosystem, not based on a single city or region, but linking all of them together. The vision of an interconnected EU startup ecosystem has been largely developed through the combined efforts of European associations, complementing the scope of the actions of national or regional agencies in the different countries, which offers a first opportunity for a more global perspective on the different aspects of startup support. However, and in spite of several cooperation initiatives between these organisations, there is still a lack of integration between their action plans, which creates gaps in startup support at EU level. This proposal will address these gaps establishing a joint agenda to build an effective collaboration amongst key players of the innovation ecosystem, fostering a common action that will inovolve key stakeholders at regional, national and EU level, that play a role in the lifecycle of start-ups growth be through upskilling initiatives, R&I programmes and policies, capacity building, private investment or access to public funding.
The Psychological Underpinnings of Nonpharmaceutical Interventions (NONPHARM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 1998168.0
EU funding (EUR): 1998168.0
Participants: 1
Project status: SIGNED

Infectious diseases cripple well-being, batter economies, and kill millions annually. These negative consequences can be drastically reduced via nonpharmaceutical interventions (NPIs) – behaviors that reduce the spread of pathogens. A wealth of recent theoretical and empirical work has illuminated how and why disgust intuitively motivates some NPIs, such as avoiding bodily wastes and spoiled foods. However, disgust does little to inhibit transmission via aerosols, respiratory droplets, and fomites – key pathways for the respiratory pathogens that circulate seasonally, have caused recent pandemics, and will cause the pandemics of the future. Hence, even with advances in our understanding of disgust, the psychological underpinnings of the less-intuitive NPIs that inhibit respiratory pathogens – such as handwashing, barriers to respiratory droplets and aerosols, and self-isolation while infectious – remain mysterious. This project addresses the urgent need to better understand these NPIs using theory and methods that cut across social psychology, evolutionary psychology, health psychology, and behavioral genetics. First, it catalogs and explains cross-cultural differences and similarities in NPI practices with an unprecedented survey of 50 nations, and it uses a state-of-the-art nuclear twin family design to assess within-population genetic and cultural transmission of NPIs. Second, it uses experimental methods to test the roles of folk theories of immunity, moralization, and conflicts between individual and collective interests on NPI practices. Third, it develops novel, theory-based interventions for increasing handwashing and voluntary quarantining while sick and uses objective assessments of soap use and total daily movements to evaluate those interventions. By providing groundbreaking data, theory development, and empirically-supported interventions, this project will arm science and society with critical new knowledge in our battle against infectious disease.

Keywords: disgust,evolutionary psychology,behavioral immune system,disease,emotion,health
Isotopically labelling of cell surface glycans to illuminate infectious processes at atomic resolution (Glyco13Cell)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Every human cell is covered by a dense coat of glycans (sugars, carbohydrates). Sugars are the first molecules that viruses encounter when they approach host cells. Many viruses encode lectins to adhere to the outer glycan layer and start infection. In this scenario, Glycoscience holds a tremendous potential for combating infections. Elucidating the molecular basis of infection is essential, but far from trivial. The complexity of the chemistry of glycans, including synthesis, structure, conformation, and dynamics hampers the full knowledge of sugar-mediated recognition events and the development of glycan-based drugs. Surfing the current information on glycan/lectin interactions, we stumble in contradictory outcomes, pointing out the tremendous difficulty of translating in vitro results to the in vivo environment, which limits the translation from the bench to clinics. I propose an unprecedented strategy to untangle the key glycan’s molecular interaction features breaking the limits in answering fundamental questions related to sugar structure, presentation, dynamics, and eventually function. I will chemically remodel the glycans, directly on the cell surface, using NMR active probes to decode their roles at atomic resolution, while preserving their presentation in a near-to-in-vivo environment. I am in a favoured position to accomplish this project due to my experience in NMR, synthesis, and mammalian cells manipulation. I will combine chemical biology tools, novel chemical and enzymatic synthesis, and NMR-based methods: From chemistry to biology and beyond. Glyco13Cell will gap down the observed differences between in vitro and in vivo results paving the way for develop novel glycan-based tools for predicting, diagnosing and treating infectious diseases. Now it’s time. The increasing understanding of infection biology with the atomic precision of modern chemical tools will make glycomics run in parallel with genomics & proteoms towards personalized medicine.

Keywords: chemo enzymatic synthesis,cell engineering,nmr probes,molecular interactions
Desynchronizing weak cortical fields during deep brain stimulation (DECODE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Netherlands,Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1498914.0
EU funding (EUR): 1498914.0
Participants: 2
Project status: SIGNED

Deep brain stimulation (DBS) is a surgical treatment for Parkinson’s disease and other neurological disorders. By applying pulsed, alternating electric currents to targets deep in the brain, DBS induces widespread changes in neural network activity. Although motor symptoms can be reduced by DBS in most patients, some patients suffer from severe side effects or insufficient symptom relief. Many attempts have been made to optimize the therapeutic effects of DBS, but these attempts have been restricted by a lack of understanding of how DBS exerts its therapeutic effects. Various therapeutic mechanisms have been proposed, but none have fully explained all of the complex effects of DBS. These theories have focused on direct and indirect effects of the strong electric fields near the stimulation contact. I propose a radically new hypothesis on the therapeutic mechanism of DBS that harnesses current insights from noninvasive brain stimulation. Weak electric fields during noninvasive brain stimulation have recently been shown to desynchronize neural activity from the surrounding network activity. I suggest that weak electric fields during DBS desynchronize cortical activity, which can, in combination with the effects of strong subcortical electric fields, reduce pathological synchrony in motor system networks and thereby restore motor control. DECODE will integrate large-scale volume conduction modeling to estimate and steer personalized electric fields, biophysical neural network modeling to understand the physiological consequences of weak fields and their interaction with strong field effects, and EEG measurements in humans to verify these models. Finally, based on the obtained knowledge and computational tools, DECODE will clinically test the hypothesis in patients with Parkinson’s disease. If successful, DECODE will start a new era in our understanding of the therapeutic network mechanisms of DBS and trigger clinical breakthroughs to optimize DBS therapy.

Keywords: deep brain stimulation transcranial alternating current stimulation biological neural networks plasticity
The role of Base molecules in AErosol formation (BAE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Cyprus,Finland
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 2248644.0
EU funding (EUR): 2248644.0
Participants: 2
Project status: SIGNED

Aerosol formation and growth mechanisms need to be better understood to improve air quality and weather prediction models, and reduce uncertainty of radiative forcing in climate change projections. Globally, half of the aerosol population is formed via gas-to-particle conversion and the fraction exceeds 90% in high latitudes. In many locations, the initial molecular cluster forms from sulphuric acid and ammonia or dimethylamine. Growth to an aerosol particle is often explained by the condensation of sulphuric acid, methanesulfonic acid and highly oxygenated organic compounds. While the roles of strong acids and organic compounds and their oxidation channels are quantified in laboratory and field studies, cation detection and neutral atmospheric base measurements are notably under-represented. An important innovation of this project will be the direct measurement of cations and neutral base molecules and clusters based on mass spectrometry. Ammonia, a base predominantly emitted by agriculture, is a key air pollutant in the formation of fine particulate matter (PM2.5). In western Europe, up to half of PM2.5 is attributed to ammonia pollution because of its ability to form aerosols in reactions with common atmospheric acids. Current atmospheric models do not include amines, which can form aerosol particles at a 1000-times faster rate than ammonia. To uncover the composition and level of toxicity of PM2.5, as well as the scattering and absorption of sunlight by aerosol particles, it is critical to understand the atmospheric chemistry and molecular pathways that control their formation and growth. The project will focus on the role of base molecules in the formation of new particles and their fate in the atmosphere and is led by an established PI with a demonstrated history in ground breaking nanoaerosol and precursor studies. It will underpin the modelling of atmospheric aerosol processes, which are subject to major precursor emission changes in Europe and beyond.

Keywords: ammonia,mass spectrometry,air pollution,base,new particle formation,aerosol
ATHENA-Pi: INDUSTRIALIZATION AND MARKET INTRODUCTION (ATHENA-Pi)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Spain
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-07-01
End date: 2023-03-31
Duration (months): 9.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Small satellite manufacturers, integrators, and their clients have proven reluctant to incorporate on-board propulsion since it comes in conflict with the already stringent payload requirements. These power/volume/mass constraints have limited historical adoption to under 7% and 1% in the nano- and pico-satellite classes. In response to the perceived market need, ienai SPACE is developing ATHENA (Adaptable Thruster based on Electrospray for Nano-/micro-/pico-satellites) an innovative electric thruster for on-board propulsion based on electrospray technology, which represents a step change in comparison to the current state-of-the-art Electric Propulsion (EP) devices; our first product is the ATHENA-π, a pico-satellite version which is currently in development and is expected to begin commercialization in 2022 Adding on-board propulsion systems will allow for custom operational orbits, cost-effective deployment of satellite constellations and increased mission lifetime in Low Earth Orbit. In addition, these systems would allow for collision avoidance and controlled deorbiting maneuvers, mitigating the growing space debris issue. The overall work plan is focused on the activities which will take ATHENA-π from a flight qualification campaign, to take place in January of 2022 (with a backup for March of 2022) to commercial success, including the initial scale-up industrialization efforts and supporting financial structure.

Keywords: scale up industrialization efforts and supporting financial structure
Decoding endothelial cell BEhavioral MOSAICism within single vessels (BEMOSAIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Spain,Israel,United States
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-07-01
End date: 2031-06-30
Duration (months): 72.0
Total project cost (EUR): 10624448.0
EU funding (EUR): 10624448.0
Participants: 3
Project status: SIGNED

Endothelial cells (ECs) form a dynamic monolayer lining the lumen of vessels. While single-cell data have revealed high degrees of heterogeneity amongst ECs at the inter- and intra-organ levels, the prevailing notion has long been that vessels themselves are composed of largely similar ECs. Instead, data from our labs challenge this view by showing that vessels are built of highly diverse ECs displaying different behavioral properties, a feature we term intravessel EC behavioral mosaicism. While these findings are promising, there is still much to learn about the range of behavioral variability among ECs within vessels and how this intricate mosaic of behaviors is orchestrated to optimize vascular function. Building on our past achievements, we now aim towards novel directions- to push forward a fresh conception of vessels, as mosaic composites of specialized ECs. Here, we will integrate our synergistic expertise in live imaging, sophisticated genetic approaches, and spatial omics to map EC behaviors in zebrafish and mice. In addition, we will harness oncogenic mutations causing vascular malformations in humans to investigate how they alter the behavioral map. Finally, we will decode mechanisms of vessel tolerance and co-optation in response to stochastic expression of mutations to understand how vessels cope with EC mosaic behaviors. The important and unique aspects of our approach are the focus on in vivo dynamics and the cross-animal and organ comparisons, which will provide much needed knowledge on vessel architecture and function, making substantial advances at the frontier of vascular biology. Overall, we envision that shifting the paradigm of vessel heterogeneity to behavioral mosaicism will provide a better understanding of vascular-related pathologies and will lay the foundation for improving vascular therapies by targeting specific EC subsets. Moreover, we expect to offer means to understand other diseases involving mosaic responses, including cancer.

Keywords: endothelial cells,vessels,vascular malformations,live imaging
Development of selective breeding programs for boosting organic fish farming that respect high animal welfare requirements, maintain biodiversity and improve fish health and resource efficiency (SelectOrganic)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Norway,Italy,Finland,France,Sweden,Denmark,Greece,Netherlands,Germany
Call: Selective breeding programme for organic aquaculture (HORIZON-CL6-2024-BIODIV-01, 2024)
Start date: 2025-09-01
End date: 2029-02-28
Duration (months): 42.0
Total project cost (EUR): 3025725.0
EU funding (EUR): 3000000.0
Participants: 20
Project status: SIGNED

The overall objective for SelectOrganic is to develop selective breeding programs for the organic farming of European sea bass, gilthead seabream, rainbow trout and Atlantic salmon, respecting high animal welfare requirements and aiming at improving species resilience, disease resistance, product quality and resource efficiency. Furthermore, we aim at fish utilizing as much alternative feed materials as possible. This will contribute to “develop and improve good practices in organic aquaculture, make sustainable use of biodiversity". Four Case Studies are outlined with different tasks in 5 WPs. Each case study addresses each of the four key species above and specific traits of economic and welfare importance in addition to key challenges in organic aquaculture. We will define breeding objectives, develop phenotyping of “new organic” traits, estimate genetic parameters and develop the required organic reproduction technology and selection methods to address critical knowledge gaps or challenges. A specific welfare auditing WP will exploit experiments from two other WPs on resource efficiency, bacterial disease resistance and heat wave resilience to test and apply species-specific fish welfare indicators. The project outcome will be technologies, methods, and strategies for selective breeding for organic fish farming, while maintaining genetic diversity and contributing to non-toxic environments and to maintain biodiversity. Finally, successful innovations, including many aiming at precision farming, will be integrated in cost-effective breeding plans for organic aquaculture. Socioeconomic studies on non-market valuation of public goods as fish welfare and ecosystem services in addition to policy incentives will involve a broad range of actors. Together with communication, dissemination, and training activities, this ensures successful exploitation and significant impact of the project output and expanded organic aquaculture in Europe.

Keywords: organic aquaculture,breeding goal,fish health,fish welfare,fish feeds,feed efficiency,reproduction,breeding strategy,breeding plans,policies,economics,climate impact,biodiversity
Innovative Digital Twins for Advanced Combustion Technologies (INVENT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium,Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-09-01
End date: 2026-02-28
Duration (months): 18.0
Total project cost (EUR): 162857.14
EU funding (EUR): 150000.0
Participants: 2
Project status: SIGNED

Significant adoption of renewable sources will be witnessed in future years to meet the long-term objective of CO2 neutrality and mitigate the effects of global warming. While electrification will play a key role in the transition to a sustainable energy system, combustion processes will remain part of the picture, requiring sustainable combustion technologies and renewable synthetic fuels. The design and development of novel combustion technologies in power and heat generation, transportation and manufacturing processes require developing a digital combustion infrastructure that promises to bring down the needed R&D investments for meeting the tightening environmental regulations. However, predicting combustion processes is a complex and challenging task, and the tools available today fall very short of what is needed for new design and optimisation. We made an innovation that formed a digital twin, combining theory, experiments, simulations and machine learning into one unique combination. With our approach, we can predict complex multi-physics systems that can be used for designing combustion-based energy generation applications for growing markets. Our approach is expected to impact significantly new combustion systems while reducing the resources and time for designing such fuel-flexible, nonpolluting and energy-efficient systems. This is expected to have vast commercialisation potential in the industries 1) designing environmentally friendly energy systems and 2) supplying digital tools for the design processes.