Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Multiscale modelling and characterization to optimize the manufacturing processes of Organic Electronics materials and devices (CORNET)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Greece,Greece,Switzerland,France,France,United Kingdom,United Kingdom,United Kingdom
Call: Systems of materials characterisation for model, product and process optimisation (H2020-NMBP-2017-two-stage, 2017)
Start date: 2018-01-01
End date: 2021-03-31
Duration (months): 39.0
Total project cost (EUR): 3993750.0
EU funding (EUR): 3993750.0
Participants: 13
Project status: CLOSED

CORNET is an ambitious project that develop a unique EU Open Innovation Environment (OIE), that cover the triangle of manufacturing, modelling and experimentation for the optimization the Organic/Large Area Electronic (OE) nanomaterials, materials behavior and nano-devices (OPVs, PPVs, OLEDs) manufacturing of R2R printing & gas transport (OVPD) processes, to validate materials models based on experimentation and fabricate tailored OE devices and systems for demonstration to industrial applications (e.g. automotive, greenhouses). CORNET will develop a sustainable OIE Platform and OIE Database for documentation of citable & industrially accepted protocols for OE material and device characterization, modelling and manufacturing. CORNET strategy will establish strong links and clustering with existing EU clusters (as EMMC, EMCC, EPPN), end-user & industrial associations, and EU networks to increase the speed of OE materials/device development and industry uptake, maximize the acceptance of the OIE and push-through standards for adoption by industry worldwide. The CORNET main objectives are to: 1. Develop an effective OIE with world-class experts in Manufacturing, Multiscale Characterization & Modelling, connected to EU clusters, and create a reliable database with citable protocols with contribution to Standards 2. Multiscale Characterization & Modelling to Optimize OE nanomaterials and devices fabrication and Models Validation 3. Optimize the nano-device Manufacturing of OPVs, PPVs, OLEDs by Printing (R2R, S2S) and OVPD Processes 4. Fabricate Tailored Devices, Systems and Demonstrate to industrial applications (e.g. automotive, greenhouses) CORNET has developed a strategic plan for the clustering activities with more than 800 existing related bodies, a Business Plan for the continuation of the OIE beyond the project and the Innovation Management, IPR and legal support services to protect generated foreground and to enable its adoption by the EU research & industrial communities.

Keywords: organic electronics,open innovation environment,multiscale characterization and modelling,nanomaterials,manufacturing process,database,perovskites,oleds,r2r printing,ovpd,automotive
The Implantable Subcutaneous String Defibrillator (ISSD), an innovative subcutaneous cardioverter defibrillator for a new paradigm in cardiac rhythm management. (ISSD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-07-01
End date: 2021-03-31
Duration (months): 33.0
Total project cost (EUR): 3519750.0
EU funding (EUR): 2463825.0
Participants: 1
Project status: CLOSED

Sudden Cardiac Arrest (SCA) is a life-threating heart condition and one of the most common causes of death in developed countries claiming many lives globally. There are currently two different implantable technologies to prevent SCAs: 1) Transvenous Implantable Cardioverter-Defibrillators (T-ICDs), which are implanted with wires that snake through veins into the heart; and 2) Subcutaneous Implantable Cardioverter-Defibrillators (S-ICD), which also have generators and leads but avoiding leads within the heart. However this solutions pose many drawbacks such as major complications to the vascular system, replacement needs, aesthetical and comfort impacts, complex implantation procedures and cyber-security issues. The ISSD introduces a new dimension in subcutaneous ICDs. It is a totally integrated device fully inserted subcutaneously, with no leads within the heart, thus remaining the vascular system untouched. It is a wireless rechargeable device, halving replacement rates when compared to current technologies and it is totally seamless and integrated, so no generators or leads are needed. This makes the device almost invisible and improves patients comfort. It is designed from a cyber-security point of view and can be implanted in a rapid outpatient procedure (20 min on average). So far, we have invested €8M which have helped us to ensure its robustness and efficiency and move into the commercialisation stage. To further develop the ISSD, overcome market barriers and deploy it at a European and global level we are seeking via the SME Instrument Phase 2 grant. The proposed work in SME instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of the ISSD and its market uptake.
Distributed System of Scientific Collections - Preparatory Phase Project (DiSSCo Prepare)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Germany,Estonia,Italy,Austria,Germany,Spain,Belgium,Norway,Bulgaria,Finland,Greece,Poland,Slovakia,Belgium,Hungary,Sweden,France,Czechia,Netherlands,Denmark,United Kingdom,Portugal,Portugal,United Kingdom,Luxembourg,United Kingdom
Call: Preparatory Phase of new ESFRI projects and early phase support to ESFRI high strategic potential areas (H2020-INFRADEV-2019-2, 2019)
Start date: 2020-02-01
End date: 2023-02-28
Duration (months): 37.0
Total project cost (EUR): 4868518.37
EU funding (EUR): 3999383.01
Participants: 34
Project status: CLOSED

With 115 organisations across 21 European countries, The Distributed System of Scientific Collections (DiSSCo) represents today the largest ever formal agreement between organisations of this type, in the world. These organisations have joined forces to develop and operate as a distributed pan-European Research Infrastructure. The DiSSCo RI works for the digital unification of all European natural science assets under common curation and access policies and practices that aim to make the data easily Findable, more Accessible, Interoperable and Reusable (FAIR). DiSSCo will deploy a comprehensive portfolio of services across three main categories: a) e-Science Services, b) Physical and Remote Access Services and c) Support and Training Services. DiSSCo Prepare acts as the main vehicle through which DiSSCo RI will raise its overall maturity and set itself in a position to implement its construction programme. DiSSCo Prepare aims at 1) improving the overall Implementation Readiness Level (IRL), and 2) delivering the DiSSCo Construction Masterplan. The DiSSCo IRL is defined as the measure of the ability to embark on specific implementation actions (construction projects) based on clear, actionable guidelines with minimum risk, and across the scientific, data, financial, technological and organisational dimensions of the infrastructure. DiSSCo Prepare will raise the readiness level of the RI across all five dimensions. The DiSSCo Construction Masterplan will be considered as the final output of the project and will effectively be used as the organisational, financial and technical guiding framework for the construction of the infrastructure (including establishing the legal entity).

Keywords: data infrastructure,biological diversity,geological diversity,natural science collections
Innovative Scientific Data Exploration and Exploitation Applications for Space Sciences (EXPLORE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Research and Innovation actions
Countries involved: Germany,Israel,Austria,France,United Kingdom,United Kingdom,Luxembourg
Call: Scientific data exploitation (H2020-SPACE-2020, 2020)
Start date: 2020-11-01
End date: 2023-12-31
Duration (months): 38.0
Total project cost (EUR): 1991273.75
EU funding (EUR): 1991273.75
Participants: 8
Project status: SIGNED

EXPLORE’s main objective is to deploy machine learning (ML) and advanced visualization tools to achieve efficient, user-friendly, realistic exploitation of scientific data from astrophysics and planetary space missions, as well as from supporting ground-based massive surveys. We will focus on six different topics, each chosen for their timely importance and their complementary data structures. This diversity and complementarity is key to a future evolution and growth of the platform that will be relevant and applicable to the broadest possible user-base within the research community. Two of EXPLORE’s topics are related to Lunar observation, two to Galactic Science and two to stellar characterization. For each of these topics, the state-of-the-art will be enhanced by introducing ML techniques and advanced visualization tools to support “Human Learning”. Project results will be disseminated to a wide range of targets communities (astronomy, AI, general public, etc) and prepared for submission as scientific papers. For each topic, specific tools will be created, called Scientific Data Application (SDA) throughout this proposal. These SDAs will be developed on a dedicated cloud solution (the EXPLORE Thematic Exploitation Platform, EXPLORE-TEP). This will be made available also on existing cloud platforms such as ESCAPE Science Analysis Platform and the ESA Datalabs, close to the input data, and open to the community for direct exploitation-on-demand. These SDAs will also be used by the consortium to produce enhanced scientific datasets for space science mission exploitation, which will be stored in appropriate archives for public access. Datasets from Gaia and recent lunar (LRO, Clementine, Chandrayaan, etc) space missions are at the core of the EXPLORE project and will be complemented by previous space missions (IUE, Galex, WISE, etc). Data from ground-based surveys (APOGEE, Gaia-ESO, RAVE, etc) will be used to provide added value to the Gaia and Lunar missions.

Keywords: open science cloud,artificial intelligence,collaborative visualisation and exploration,galaxies,stars,moon
Training European Experts in Multiscale Studies of Neural Crest Development and Disorders: from Patient to Model Systems and Back again. (NEUcrest)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Spain,Ireland,Israel,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-11-01
End date: 2024-04-30
Duration (months): 54.0
Total project cost (EUR): 4156404.84
EU funding (EUR): 4156404.84
Participants: 11
Project status: SIGNED

Neurocristopathies caused by defects in the neural crest (NC) encompass a broad group of diseases from birth defects (cleftvpalate) to complex syndromes affecting systems such as heart, gut and adrenals. Because NC derivatives are diverse, mutations affecting this lineage can lead to pleiotropic phenotypes making it difficult to understand the causative events. Furthermore, NC-derived cancers, (e.g. melanoma and neuroblastoma) reactivate embryonic programs during tumour initiation. Our aim is to create a unique interdisciplinary network of scientists and clinicians partners from academia, healthcare, industry and the public sector with experience in gene discovery, genetics, functional studies and in vivo phenotyping aimed at training creative and innovative ESRs to study the overall genetic, molecular and environmental regulation of NC tissue in human health. To study each of complex aspects of NC and tumour formation, NEUcrest provides a synergistic framework for comprehensive analysis of candidate genes and biological processes, from patients to model systems to pharma and back to the clinic. With the aim to develop a unified strategy to identify new genetic and environmental factors that contribute to disease and to develop new drug targets for therapeutics, ESRs will address following scientific challenges: undertake novel gene discovery approaches; establish cellular/animal models of disease; establish integrative strategies for understanding neurocristopathies; optimise computational modelling of NC gene networks; establish translational strategies for drug screening in NC-related diseases; improve clinical management strategies of NC-disease and interface with patients and the public. Our training program takes into account training through research as well as multidisciplinary partnerships and networking opportunities. All together, this will improve our understanding of the fundamentals of neurocristopathy and contribute to improvements in healthcare.

Keywords: multidisciplinary training,genetic disorders,genomics and functional genomics,genetic and molecular diagnostic tools,cancer and biological basis,drug discovery,bioinformatics
PeRsOnalized Integrated CARE Solution for Elderly facing several short or long term conditions and enabling a better quality of LIFE (PROCare4Life)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Innovation actions
Countries involved: Germany,Spain,Italy,Germany,Germany,Romania,Netherlands,Netherlands,Portugal,Portugal
Call: Large Scale pilots of personalised & outcome based integrated care (H2020-SC1-DTH-2019, 2019)
Start date: 2020-01-01
End date: 2023-06-30
Duration (months): 42.0
Total project cost (EUR): 6761437.5
EU funding (EUR): 5685937.5
Participants: 17
Project status: SIGNED

The main contribution of PROCareLife consists in proposing an integrated scalable and interactive care ecosystem, which can be easily adapted to the reality of several chronic diseases, care institutions and end-user requirements, benefiting all the involved actors, from patients, to caregivers and health professionals. Its main contributions consist of: (a) building an integrated scalable and interactive care ecosystem for neurodegenerative diseases and adaptable to other chronic conditions; (b) finding the best actions/measures from a medical and social point of view that can facilitate an improved quality of life, awareness and care management for senior users suffering of neurodegenerative and/or other chronic diseases; (c) provide a personalized recommendation and interaction model, which can support the user through gamification techniques to adopt healthy habits, maintain a good daily routine and follow the prescribed actions by the professionals for maintaining and improving their health condition; (d) enable multi-disciplinary communication between all involved stakeholders, better time management for social and health professionals and contribute to achieving a cost-efficient, flexible and high adaptable solution for senior users suffering of short or long term conditions.
Single-cell spatiotemporal analysis of Mycobacterium tuberculosis responses to antibiotics within host microenvironments (SpaTime_AnTB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is an intracellular pathogen that killed 1.6 million people in 2017. Despite its enormous relevance for TB treatment, how intracellular environments affect the response of Mtb to antibiotics remain poorly characterised. This gap in knowledge is mainly due to the lack of appropriate technologies that have precluded comprehensive understanding of the response of intracellular pathogens to antibiotics, critical to design rational interventions. Here, I propose to use cutting-edge imaging approaches to define: (i) Mtb responses towards specific host-subcellular microenvironments by single-cell live long-term imaging in infected human stem cell-derived macrophages (iPSDM); (ii) the dynamics of antibiotic-mediated killing mechanisms using mycobacterial fluorescent reporters and high resolution correlative microscopy and (iii) the spatial and metabolic features of the Mtb response to antibiotics in vivo using a TB mouse model. For this, I will capitalise on technologies developed in the host group to quantify Mtb localisation and replication at the single-cell level combined with correlative electron microscopy (CLEM and CLEIM) approaches. This project will challenge the current limits of high content imaging by combining iPSDM with micro-patterning technologies for single-cell analysis. This will allow the identification of Mtb responses to antibiotics in host cells and how different intracellular microenvironments impact this process in cellulo and in vivo. Together, this proposal has the potential to uncover novel mechanisms of action of antibiotics in human macrophages, opening new avenues for a deeper understanding of human TB treatment and facilitate the discovery of new antibiotics.

Keywords: macrophage,tuberculosis,antibiotic,imaging,live cell
Versatile Integrated Accelerator-based Heterogeneous Data Centres (VINEYARD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Greece,Greece,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,Luxembourg,Portugal
Call: Customised and low power computing (H2020-ICT-2015, 2015)
Start date: 2016-02-01
End date: 2019-01-31
Duration (months): 36.0
Total project cost (EUR): 6283895.0
EU funding (EUR): 6283895.0
Participants: 12
Project status: CLOSED

VINEYARD will develop an integrated platform for energy-efficient data centres based on new servers with novel, coarse-grain and fine-grain, programmable hardware accelerators. It will, also, build a high-level programming framework for allowing end-users to seamlessly utilize these accelerators in heterogeneous computing systems by using typical data-centre programming frameworks (e.g. MapReduce, Storm, Spark, etc.). VINEYARD will develop two types of energy-efficient servers integrating two novel hardware accelerator types: coarse-grain programmable dataflow engines and fine-grain all-programmable FPGAs that accommodate multiple ARM cores. The former will be suitable for data centre applications that can be represented in dataflow graphs while the latter will be used for accelerating applications that need tight communication between the processor and the hardware accelerators. Both types of programmable accelerators will be customized based on application requirements, resulting in higher performance and significantly reduced energy budgets. VINEYARD will additionally develop a new programming framework and the required system software to hide the programming complexity of the resulting heterogeneous system based on the hardware accelerators. This programming framework will also allow the hardware accelerators to be swapped in and out of the heterogeneous infrastructure so as to offer efficient energy use. VINEYARD will foster the expansion of the soft-IP cores industry, currently limited in the embedded systems, to in data centre market. The VINEYARD consortium has strong industrial foundations, and covers the whole value chain in the data-centre ecosystem; from the data-centre vendors up to the data-centre application programmers. VINEYARD plans to demonstrate the advantages of its approach in three real use-cases a) a bioinformatics application for high-accuracy brain modelling, b) two critical financial applications and c) a big-data analysis application.

Keywords: data centres,hardware accelerators,dataflow engines,mapreduce,cloud computing,heterogeneous computing,reconfigurable computing,fpgas
Theoretical study of cold and ultracold collisions in triatomic systems using inner-region nuclear motion wavefunctions and outer-region R-matrix propagation (Rmat3)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2018-06-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

A "quiet revolution" is occurring at the "border between atomic physics and experimental quantum chemistry" (Annu. Rev. Phys. Chem., 2014, 65, 501-518). Techniques for producing cold and ultracold molecules are enabling the study of chemical reactions and scattering at the quantum scattering limit with only a few partial waves contributing to the incident channel leading to the observation and even full control of state-to-state collisions in this regime. Rmat3 will develop a new formalism and allied codes for tackling problems for triatomic molecules involving low- and ultra-low energy collisions. Though this project focuses on triatomics, the formalism is completely general and could prove transformative in its scope. It is particularly appropriate for slow collisions occurring over deep wells. The many resonance states make such systems hard to treat theoretically but offer the best prospects for novel physics: resonances are being widely used to control diatomic systems and should provide the route to steering ultracold reactions. Rmat3 will build on the progress made in variational calculations of molecular spectra by using these methods to provide rovibrational wavefunctions for the whole system at short internuclear distances. These wavefunctions will be used to construct collision-energy-dependent R-matrices which can then be propagated to give products as a function of collision energy. The methods will be used to study ultracold collisions in triatomic systems in conjunction with leading European experimental groups, focusing on the H2O and H3+ systems for which spectroscopically accurate potential energy curves are already available. The project will focus on elastic and inelastic collisions and reactive scattering.s The new methodology explored in Rmat3 can be extended in the future to treat larger molecular systems as well as photodissociation and photoassociation, charge exchange and predissociation. The Rmat3 code will be made freely available to the scientific community.

Keywords: cold molecules,scattering,collisions