Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Resilient beekeeping and breeding to safeguard natural genetic resources and pollination services (BeeGuards)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Italy,Israel,Belgium,Germany,Denmark,Greece,Croatia,Poland,Slovenia,Sweden,Argentina,North Macedonia,Malta,Austria,Spain,United Kingdom
Call: Resilient beekeeping (HORIZON-CL6-2022-BIODIV-02-two-stage, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 5495685.0
EU funding (EUR): 5495682.5
Participants: 27
Project status: SIGNED

BeeGuards aims to strengthen the resilience of the European beekeeping sector by providing sustainable management practices, novel breeding strategies and digital and forecasting tools that allow the sector to adapt to a changing environment. We focus on determining how abiotic factors such as management practices, climate change, nutrition and resource limitations drive emerging biotic stressors that threaten colony health and erode the resilience of European beekeeping. BeeGuards comprises multiple actors and adopts a multi-actor approach from inception which has led to an open and inclusive design of the work programme. As a community, we will perform European-wide field studies evaluating and validating innovative threshold-based management and breeding strategies for resilience, using hives equipped with technological measurement tools. Complementary detailed immunological, behavioural, microbiological, pathological, ecological investigations will elucidate the ways in which management and climate act on honey bees and other pollinators. In this way, BeeGuards will, for the first time, provide a truly holistic view of the mechanisms determining beekeeping resilience and implement nature-based, local solutions for adaption, including model-based advisory tools for stakeholders. Our open and participatory actions include development of a WikiBEEdia community website where we will share and promote the BeeGuards concepts and results, including a Quest for sustainable beekeeping practices. Ultimately, BeeGuards will show the way for a change of perspective that is needed to achieve resilient beekeeping. BeeGuards will mitigate the environmental impact of beekeeping in terms of impact on wild pollinators and of carbon footprint, protect pollinator biodiversity, ensure the future provision of pollination services and support the economic development and inclusiveness of beekeeping, preparing the European apicultural sector to meet the climate challenge.

Keywords: holobiont,digital data,technological devices,modeling,decision support systems,genomic selection,life cycle analysis,breeding for varroa resistance carbon footprint pollinator protection
A Space Warehouse Concept and Ecosystem to Energize European OSAM (STARFAB)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Belgium,France,Germany,United Kingdom
Call: Future Space Ecosystem and Enabling Technologies (HORIZON-CL4-2023-SPACE-01, 2023)
Start date: 2024-01-01
End date: 2026-06-30
Duration (months): 30.0
Total project cost (EUR): 3277174.77
EU funding (EUR): 2416797.81
Participants: 5
Project status: SIGNED

Implementing sustainable commercial activities in Earth orbit requires not only the key technologies necessary to offer the targeted services (OOS / ISAM) but also the means to effectively ensure the (re)supply of the associated facilities. Storage and handling of goods and resources in orbit, in support of OOS or ISAM, have received limited attention in the perspectives and roadmaps of the major future space ecosystem and economy players. STARFAB aims to explore a novel concept of an automated orbital Warehouse Unit (WU) within the context of both OOS and ISAM (also known as OSAM) commercial perspectives. It seeks to address a critical gap in the future space ecosystem, serving as an enabler for sustainable OSAM business models. The STARFAB project will develop a Phase A equivalent concept and demonstrator of an orbital Warehouse Unit (WU), drawing inspiration from the state-of-the-art automated warehousing practices on Earth, while considering the challenging environmental conditions encountered in space, such as microgravity, vacuum, extreme temperatures, and radiation. STARFAB's objective is to advance the necessary technologies for handling goods in space (including modular and custom-shaped components, raw materials for manufacturing, fuel, water, and more), using robotics and automation. This will encompass storage elements with varying levels of protection, the Items Handling Solution (IHS), featuring custom automation tools for operations within the warehouse structure, and the Item Transfer System (ITS), designed as a robotic manipulator to provide flexible external item transfer within the WU. The STARFAB concept will also include provisions for robotic inspection and minor maintenance tasks, primarily for STARFAB's own integrity but possibly also as a service for spacecraft docking or berthing with STARFAB. At the end, STARFAB will produce a roadmap outlining the path forward for technology maturation, model philosophy, market opportunities, and subsequent exploitation measures

Keywords: warehouse automation,storage,space robotics,oos,osam,circular economy,space ecosystem,space economy
Bridging the gaps in nanosafety for animal-free prediction of adverse outcomes (nanoPASS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Slovenia,Germany,Denmark,Norway,Sweden,Ireland,Belgium
Call: Advanced characterisation methodologies to assess and predict the health and environmental risks of nanomaterials (RIA) (HORIZON-CL4-2022-DIGITAL-EMERGING-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 3073736.25
EU funding (EUR): 3073736.25
Participants: 9
Project status: SIGNED

The current animal-based testing of materials’ short- and long-term health effects is slow, expensive, and has limited capacity, which stifles the development of new (nano)materials and hinders efficient regulation of the market. To enable cost-efficient high-throughput screening required for industry and regulation, we here propose to shift the focus of nanosafety testing from late endpoints to early key events (KEs) leading to adverse outcomes (AOs). As such tests can only be based on mechanistic understanding, we need to close the knowledge gaps and match KEs in vitro and in vivo, which the nanoPASS consortium is in a unique position to provide. Our key bridging methods are intravital in vivo microscopy, quantitative time-lapse in vitro microscopies, and automated identification of the modes of action (i.e. KE relationships) with proprietary in silico algorithms, supported by datamining of the worlds’ largest in vivo database and single-cell omics data, and computational modelling of structure-function relationships. With this toolset, we aim to 1) develop new in vitro systems that can replicate early KEs leading to AOs related to inhalation of NMs, 2) identify methods to track the dynamics of these KEs, 3) develop quantitative in silico models to predict AOs, and 4) calibrate the in vitro/in silico AO predictions against in vivo data for 40+ well-characterised benchmark materials. Finally, we will 5) validate the AO predictions on several families of industrial materials, sampled from different stages of their life cycle, and then propose reliable testing protocols and guidelines to OECD and ECVAM. With the consortium of 6 complementary research laboratories, SME as technology developer and provider, material producing company as potential end-user, and an industrial association to facilitate dissemination, nanoPASS covers the whole value chain of the new animal-free safety testing technology, and thus paves the way towards safe adoption of new nanotechnologies.

Keywords: air pollution,particulate matter,exposure monitoring,material production and recycling,nanoplastics,lung toxicity,neurodegeneration,molecular initiating events,aop,qsar,optical microscopy
Design, manufacturing, and validation of ecocycle electric traction motor (VOLTCAR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Partnership: 2ZERO (co-programmed)
Countries involved: Finland,Germany,Slovenia,Ukraine,Belgium,Cyprus
Call: Nextgen EV components: High efficiency and low cost electric motors for circularity and low use of rare resources (2ZERO) (HORIZON-CL5-2022-D5-01, 2022)
Start date: 2023-02-01
End date: 2026-09-30
Duration (months): 44.0
Total project cost (EUR): 5997135.75
EU funding (EUR): 5997135.75
Participants: 12
Project status: SIGNED

As a response to the need to decrease the transportation related emissions and energy consumption, today, all major passenger car and other light-duty vehicle manufacturers are broadening their electric vehicle portfolio. The dependency of the present electrical traction motors on the rare materials, such as rare earth permanent magnet materials, namely Neodymium-Iron-Boron magnets, is problematic from several viewpoints: they are imported and expensive and there is a real risk for supply problems in the coming years. To strengthen the European competitiveness, VOLTCAR ('Design, manufacturing, and validation of ecocycle electric traction motor') proposes high-speed, permanent magnet assisted synchronous reluctance technology with a drastic reduction in rare materials' utilisation. During VOLTCAR, the motor prototype is perfected to meet the strictest performance requirements (power density, efficiency), sustainability criteria (recyclability, circularity and low use of rare resources and copper) and the expectations of the automotive sector (cost, reliability, integrability). This major goal is supported by introducing digital design and optimisation methodologies that are capable of assessing the life cycle costs, energy consumption, and carbon footprint in the early phase, guiding the outcomes towards maximised sustainability with reduced use of rare materials and efficient recycling and repurposing patterns. The validity of the VOLTCAR motor prototypes, 50 kW and 120 kW motor, and related technologies is proved according to the automotive standards, presenting an X-in-the-loop (XiL) experimentation environments. With this development, VOLTCAR will simultaneously lead to more green jobs in local SMEs throughout Europe to reduce unemployment rate. The VOLTCAR consortium comprises world-leading automotive Tier 1 and Tier 2 companies and research partners with complementary knowledge and expertise for the successful execution of the proposed work.

Keywords: high speed permanent magnet assisted synchronous reluctance motors,ecodesign,digitalised motor,virtual and experimental validation,recyclability,circularity
Secure post-quantum cryptographic primitives (SQPRIM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

Quantum computers pose a huge threat to cybersecurity, with the potential of solving complex problems in just a fraction of the time it takes to the most powerful supercomputers today. With conventional public key infrastructure (PKI) cryptography at risk, we face the task of securing our digital systems with the development of new cryptographic primitives for the post-quantum era. Inspired by nature, this project aims to developing the biometric equivalents of fingerprints and DNA for the digital world that will univocally and individually identify hardware. For this goal, Physically Unclonable Functions (PUFs) will be developed to provide hardware-based digital identifiers that will be utilised to build lightweight encryption and robust authentication procedures. But creating such unique structures is challenging in a fast-growing digital environment with increasing demand for new interconnected devices, such as the Internet of Things (IoT). To achieve this goal, we will combine light and sound. We will use ultrasound (US) waves to control the travel path of a light beam transmitted through a scattering medium to generate unique patterns. This novel method can potentially generate a high number of unique patterns while reducing the cost and complexity compared to current systems exploiting optical PUFs. The proposed device is expected to be unconditionally unclonable and, therefore, safe in the post-quantum era. This project will also explore the integration of the proposed novel PUFs with CMOS-based cryptographic primitives to create IDentity of Things (IDoT). The proposed solution is expected to be of relevance in a wide spectrum of application domains such as financial systems, medical services, energy industry, governments, and citizens.

Keywords: puf,cybersecurity,photoacoustic effect,ultrasound,optical scattering,speckle pattern,iot,cryptographic primitive,optical sensor,photonics,quantum security
Role of estrogen signaling to astrocytes in the hypothalamus in the development of obesity. (SHAPE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-06-08
End date: 2028-06-07
Duration (months): 24.0
Total project cost (EUR): 232916.16
EU funding (EUR): 232916.16
Participants: 1
Project status: SIGNED

Obesity is a complex condition that causes around 1.6 million deaths each year. The metabolic alterations to an obesigenic environment are highly dependent on the sex of the individual. In the brain, the hypothalamus controls energy homeostasis by fine tuning feeding and energy expenditure to nutrient availability. Disruption of this regulation results in obesity. While hypothalamic neurons are crucial for the control of energy balance, their activity is tightly dependent on adequate delivery of energy substrates provided by astrocytes, the major type of glial cells in the brain. Whether nutritional challenges evoke sex-specific astrocyte adaptations and its contribution to the sex-dimorphism in the pathogenesis of obesity remains unknown. Interestingly, estrogen signaling is an essential target that mediates sexual differentiation in the brain. This project’s main aim is to determine the role of estrogen signaling in astrocytes in: 1) hypothalamic astrocytic adaptations to obesity, 2) energy metabolism in lean and obese conditions and 3) in the beneficial effects of incretin-based therapies against obesity. The present proposal intends to combine interdisciplinary expertise in astrocyte biology and neural control of metabolism to expand the understanding on the involvement of hypothalamic astrocytes in the development of obesity in a sex-dependent manner. The cutting-edge approach of ex vivo and in vivo astrocyte-selective targeting of estrogen signaling in specific hypothalamic areas, extends beyond the neuro-centrist approach by demonstrating that functional remodeling of hypothalamic astrocytes in response to nutrient overload represents a key step for the development of novel cell-selective therapeutic approaches for treating obesity and associated pathologies.

Keywords: hypothalamus,astrocytes,obesity,estrogen
Nanoscale Bioanalytical measurements of Exosome Release to gain insight into the initiation of Short-Term Memory (NanoBioER-STM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: CLOSED

The aim of this proposed research is to determine the molecular paradigm for initiation of STM based on exosome release. Despite the vital role in neural disorders, the molecular mechanism to initiate STM remains a mystery. Understanding the mysterious mechanism of the STM initiation at the molecular level from how the exosome modulates synaptic strength and plasticity to effect memory is difficult to establish, as it requires advanced analytical measurements at the level of nanometer exosomes and synaptic cleft to monitor individual exosome exocytosis events. "NanoBioER-STM" will quantitative measure exosome release at single cell level and clarify it is another pathway of exocytosis through new analytical nanoelectrochemistry (Work Package 1), and will determine how exosome release in the presence of endogenous (lipids and zinc) and exogenous effectors (cognition enhancing drugs) is regulated and will correlate these changes to the molecular initiation of STM (Work Package 2 and 3). These changes, which might alter the cell communication, can be hypothesized to be the initial step that alters synaptic plasticity and commencement of STM. These studies will be developed based on state of the art analytical techniques including subcellular nanoelectrochemistry, Nano Secondary Ion Mass Spectrometry (NanoSIMS) and Stimulated Emission Depletion (STED) super-resolution nanoscopy on model cells and simple animal nerve cells. Overall, this project will provide new insights into the pathogenesis of neurodegenerative disorders, ultimately driving the development of exosomes as diagnostic biomarkers and therapeutic measures. Implementation of this project will also be a major innovation in the field of both neurochemical research and electrochemical sensing, which will provide innovative analytical approaches for modern brain science discoveries.

Keywords: nanoelectrochemitry,bioanalytical mesurement,bioanalytical chemistry,exosome release mass spectrometry immaging short term memory stimulated emission depletion nanoscopy
SWESTEP CC Technology - The Next Step to Fossil independence and Circularity (SWESTEP - Trash2Cash)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

CHALLENGES ADDRESSED SWESTEP tackles two of the global challenges: • The supply of circular, sustainable fuels and oil for performance chemicals to potentially replace also other oil based end products • The search for environmentally friendly solutions for waste treatment and recycling: This addresses environmental, health and economic problems related to waste management WHY SWESTEP IS UNIQUE 1) The process allows for an exceptionally versatile range of input material. All hydrocarbon based materials can be used. Contaminated fossil oils can also be refined with a low environmental impact, giving a possibility to bridge feedstocks from fossil to non-fossil over time. 2) The Catalytic Conversion Technology process uses low temperature and low pressure. The proprietary catalytic direct liquefaction technology mimics the natural crude oil production process, shortening the process to below 6 minutes. This makes SWESTEP a fully sustainable and eco-friendly solution 3) SWESTEP produces renewable synthetic fuels/oil/performance chemicals that can replace fossil oil products to 100% with no engine or infrastructure adaptations. It can be used stand-alone or mixed, using it as a drop in. SWESTEP WILL BE SUCCESSFUL BECAUSE SWESTEP is currently in project negotiations amounting to 430€M, with a project pipeline of over 7€B. The market traction demonstrates our high degree of product/market fit and paves the way for the development of a solid customer base. Through a previous test plant producing 150 l/h, TRL7 has been reached. Commercial installations of 250-1800 l/h were delivered prior to SWESTEPS acquisition and further development of the base technology. For this reason, we know that the technology has proven itself and are confident that our competent and experienced team will be able to smoothly manage the proposed construction activity and project management provided for this EIC-Accelerator project. Funding application approximately 2.5€M Grant / 11.1€M Equity

Keywords: waste management,recycling technology,catalytic conversion technology,synthetic fuels,renewable fuels,synthetic diesel,saf,renewable shipping fuels,co2 saving,co2 capture,circular society