Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ready-to-use 3D Cell Cultures for early de-risking in drug development (3DCC)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Spain
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

StemTek is a global biopharmaceutical company with a clear stem cell focus in drug development for cancer treatment. Only about 10% of the candidate compounds progress successfully through clinical development. Many drugs fail during clinical trials, especially during phase III, which is the most expensive phase of clinical development, largely due to the lack of clinical efficacy and/or unacceptable toxicity. StemTek is developing a solution to make cell based assays a commodity: easy to get, easy to buy, easy to use, and disposable, so we eliminate the need for large tissue culture facilities. This new solution is a ready-to-use 3D spheroid culture in standard 96 well plate format that allows customers to profile their pipeline of compounds for their effect on CSC populations using 3D culture models. Thanks to the 3DCC, a business opportunity appears to develop a multi-million euro business capitalizing on the thriving interest from Pharma in finding novel biological testing systems based on 3D cell culture. Latest Markets&market report (2016) establishes that the global 3D cell culture market is expected to reach USD 1,345.2 M by 2021 from USD 466.8 M in 2016 at a CAGR of 23.6% (market growth). According to BCC research, from the seven different niches, “Reagents, media and sera” is precisely the most relevant (37.2 %). 3DCC objectives are: • To produce tailor made kits to improve compatibility with different drug development programs, leading to a broad range of applications. • To use all the competitive advantages of CSC enriched 3D spheroid cultures in ready to use standard 96 well plate format. • The large-scale production of ready to use kits to be able to enter/supply the pharmaceutical industry to achieve economies of scale, and go from current 800 kits/year (manually) up to 120.000 kits per year. • The integration of CSC testing into the drug development strategy of top 10 Big Pharma companies.

Keywords: cancer stem cell,drug discovery,high throughput screening,method,assay,compound validation,spheroid,sphere,tumorosphere
REnaissance of Places with Innovative Citizenship and TEchnolgy (REPLICATE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Innovation actions
Countries involved: Spain,Italy,Germany,Spain,Spain,Spain,Italy,Italy,Germany,Germany,Spain,Italy,Switzerland,Türkiye,Türkiye,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Smart Cities and Communities solutions integrating energy, transport, ICT sectors through lighthouse (large scale demonstration - first of the kind) projects (H2020-SCC-2015, 2015)
Start date: 2016-02-01
End date: 2021-01-31
Duration (months): 60.0
Total project cost (EUR): 29268376.03
EU funding (EUR): 24965263.09
Participants: 45
Project status: CLOSED

The objective of REPLICATE is to demonstrate Smart City technologies in energy, transport and ICT in districts in San Sebastia, Florence and Bristol addressing urban complexity and generate replication plans in other districts and in follower cities of Essen, Nilufer and Lausanne. Main challenges for cities are to increase the overall energy efficiency, to exploit better local resources in terms of energy supply and demand side measures. For successful implementation of Smart City technologies two main elements are considered: - Cities are the customer: considering local specificities in integrated urban plans and the need to develop monitoring systems to extract conclusions for replication. - Solutions must be replicable, interoperable and scalable. REPLICATE considers also the complexity of cities, the tangible benefits for citizens, the financial mechanisms and the new business models. The 3 pillars implemented in the pilots with the engagement of citizens, private actors and authorities are: - Low energy districts: cost-effective retrofitting, new constructive techniques with optimal energy behaviour and high enthalpy RES in residential buildings. Include also efficient measures in public and residential buildings: ICT tools, PV, shading or natural ventilation; district heating is demonstrated hybridising local biomass, recovered heat and natural gas. - Integrated Infrastructure: deployment of ICT architecture, from internet of things to applications, to integrate the solutions in different areas. Smart Grids on electricity distribution network to address the new challenges, connecting all users: consumers, producers, aggregators and municipality. Intelligent lighting will allow automated regulation of the amount of light and integration of IP services via PLC. - Urban mobility: sustainable and smart urban bus service, electric urban bike transport, 3-wheeler delivery and transport services, deployment of EV charging infrastructures and ICT tools.

Keywords: electric mobility replicability ict platform
CO-producing Nature-based solutions and restored Ecosystems: transdisciplinary neXus for Urban Sustainability (CONEXUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Protection of the environment, sustainable management of natural resources, water , biodiversity and ecosystems
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Spain,Italy,Argentina,Spain,Germany,Italy,Germany,Sweden,Colombia,Romania,Sweden,Netherlands,Netherlands,Netherlands,Brazil,Portugal,Chile,Peru,United Kingdom
Call: Strengthening international cooperation on sustainable urbanisation: nature-based solutions for restoration and rehabilitation of urban ecosystems (H2020-SC5-2019-2, 2019)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 5635956.25
EU funding (EUR): 4999940.0
Participants: 34
Project status: SIGNED

Cities and regions in Europe (EU) and Community of Latin American & Caribbean States (CELAC) face shared and urgent global-local challenges to integrate practical actions with strategies to achieve greater inclusion, biodiversity, climate change adaptation and environmental quality. Many cities share problems of landscape fragmentation caused by rapid growth, urban sprawl and economic restructuring. Poorly planned urbanisation leaves a legacy of cities lacking the green areas needed for ecosystems to provide the services essential to human life. Nature-Based Solutions (NBS) have the potential to help reverse these trends, and our combined EU-CELAC palette of socio-cultural, ecological and governance contexts represents a huge opportunity to move forward - faster, together. CONEXUS will co-produce, structure and promote access to the shared, contextualised knowledge needed to support cities and communities to co-create NBS, and to restore urban ecosystems, to help drive the required step-change in urban policy and practice in EU and CELAC countries. It adopts a planetary health perspective: healthy landscapes and ecosystems are vital to support human life, and humanity must restore, create and care for these landscapes and ecosystems in a reciprocal, ongoing and iterative relationship. This transdisciplinary project uses nature-based thinking (NBT) to bring together community, private, public and research partners to meet this challenge, and experiments with novel co-production methods to deliver NBS innovations in ‘Life-Lab’ pilots. The project’s core concept is to co-create context-appropriate NBS for ecosystems restoration and sustainable urbanisation in CELAC and EU cities, using a place-based approach (place-making, place-keeping and place-prescribing), solving problems together with citizens. The CONEXUS cities are: in CELAC - São Paulo, Bogotá, Santiago and Buenos Aires; and in the EU - Lisbon, Barcelona and Turin.

Keywords: nature based solutions
Machine Learning-based Market Design (MIAMI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-12-01
End date: 2023-11-30
Duration (months): 60.0
Total project cost (EUR): 1375000.0
EU funding (EUR): 1375000.0
Participants: 1
Project status: SIGNED

Market designers study how to set the "rules of a marketplace" such that the market works well. However, markets are getting increasingly complex such that designing good market mechanisms "by hand" is often infeasible, in particular when certain design desiderata (such as efficiency, strategyproofness, or fairness) are in conflict with each other. Moreover, human agents are boundedly-rational: already in small domains, they are best modeled as having incomplete preferences, because they may only know a ranking or the values of their top choices. In combinatorial domains, the number of choices grows exponentially, such that it quickly becomes impossible for an agent to report its full valuation, even if it had complete preferences. In this ERC grant proposal, we propose to combine techniques from "machine learning" with "market design" to address these challenges. First, we propose to develop a new, automated approach to design mechanisms with the help of machine learning (ML). In contrast to prior ML-based automated mechanism design work, we explicitly aim to train the ML algorithm to exploit regularities in the mechanism design space. Second, we propose to study the "design of machine learning-based mechanisms." These are mechanisms that use machine learning internally to achieve good efficiency and incentives even when agents have incomplete knowledge about their own preferences. In addition to pushing the scientific boundaries of market design research, this ERC project will also have an immediate impact on practical market design. We will apply our techniques in two different settings: (1) for the design of combinatorial spectrum auctions, a multi-billion dollar domain; and (2) for the design of school choice matching markets, which are used to match millions of students to high school every year.

Keywords: market design,economics and computation,mechanism design,auctions,machine learning
Manufacturing of biodegradable and compostable packaging nets through a conventional one-step extrusion process (BioPackNet)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

European demand for plastic in 2014 was 47.8 M tonnes, of which 90% came from non-renewable sources. Moreover, 25.8 M tonnes of plastics ended up in the rubbish, with 30.8% completing their life cycle in landfills. Suitable sites for landfill across Europe are running out and public concerns are increasing about the impact of landfill on the environment and health. Reducing the quantities of waste that ultimately ends up in landfill has become imperative in the EU (Landfill Directive 1999/31/EC) and represents a particularly difficult task to achieve. Recycling is one of the most important actions currently available to reduce the impact of waste and plastic production. However, some packaging items such as nets (e.g used to package potatoes, oranges) are not suitable to be treated in recycling facilities as they are difficult to be cut and get entangled in the sorting equipment ending up as waste in landfills. One possible solution is the development of biodegradable and compostable materials that could be processed through extrusion melt spinning (EMS) to manufacture these nets. Some advances have been made in this area but the high price of the final packaging product make these alternatives economically unviable. Ecoplas, a spanish manufacturer of packaging nets has come up with a solution: Biopacknet. Biopacknet will be the first packaging net with improved physical characteristics that will be processed through conventional EMS, saving energy, quantity of material and above all at a competitive cost. Biopacknet will turn into compost when it reaches its end of life, giving life to plants that will become raw materials for biopolymers in Biopacknet's formulation, closing the loop to a circular economy. With sales of 1312 tonnes of packaging net, a turnover of €5,5M and 8 new jobs created in just 3 years of commercialization Ecoplas will be able to double its revenue in just 6 years while helping businesses adopt more sustainable practices in the EU.

Keywords: biodegradable,compostable,plastic,extrusion melt spinning,packaging
European Colonial Heritage Modalities in Entangled Cities (ECHOES)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Research and Innovation actions
Countries involved: Poland,France,Netherlands,Denmark,Portugal,United Kingdom
Call: Strengthening Europe's position in the global context: science diplomacy and intercultural relations (H2020-SC6-ENG-GLOBALLY-2017, 2017)
Start date: 2018-02-01
End date: 2021-07-31
Duration (months): 42.0
Total project cost (EUR): 2461890.0
EU funding (EUR): 2461890.0
Participants: 6
Project status: CLOSED

ECHOES addresses a pressing dilemma at the heart of contemporary Europe: the fact that while the history of empires and colonialism undoubtedly constitutes a shared European past, this past remains strangely silent in official narratives about Europe’s ‘heritage’; those things it values enough to save for future generations. We argue that the EU urgently needs not just to acknowledge this dilemma but to reflexively and progressively include it at the heart of its identity. ‘Europeanising’ difficult colonial heritage is becoming all the more necessary today as the EU operates in increasingly global contexts, relationships and geographies, where its ongoing ‘deficit’ towards accepting colonialism as a part of European history collides with the palpable ‘surplus’ of colonial memory in much of the outside world with which Europe grows ever more entangled. ECHOES therefore proposes that the memory of colonialism needs to find its place in contemporary European heritage debates. Drawing on the proven expertise of a team of leading international scholars, ECHOES will show that it is through exploring the creative activities and engagements with colonial legacy in European and non-European cities still imbued with manifold traces of the colonial past that one can identify new forms of progressive heritage practice. Through a facilitation of horizontal science diplomacy between cities and the creation of new links and partnerships with artists, museums and civic groups, ECHOES will foster new future-oriented forms of intercultural dialogues based on de-colonial understandings of colonial relations. When lifted to a European level this science diplomacy will contribute to a rethinking of existing tensions between Europe and its global neighbours.

Keywords: colonial heritage,intercultural dialogue,history and memory,museums,heritage practice
Enhancing innovation management capacities of SMEs in Montenegro (MontEENegro)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Montenegro
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 15221.25
EU funding (EUR): 15221.0
Participants: 4
Project status: CLOSED

Enterprise Europe Network is a main support instrument for innovation in SMEs. It will provide innovation support services as well as information and advisory services such as mentoring, coaching and partner search activities for SMEs wishing to develop cross-border innovation projects. Innovation support, as a service that EEN Montenegro will deliver, will be offered through two packages - Key Account Management (KAM) to support the innovation capacity of successful “SME instrument” applicants benefiting from Horizon 2020 specific supporting mechanism, and Services to enhance the innovation management capacity of SMEs in Montenegro in order to improve their effectiveness and efficiency, in particular aimed at those with significant innovation activities and a real potential for international growth.
Research Infrastructures for Phenotyping, Archiving and Distribution of Mouse Disease Models - Promoting International Cooperation and User Engagement to Enhance Biomedical Innovation (IPAD-MD)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Coordination and support actions
Countries involved: Germany,Spain,Germany,Spain,Italy,France,Czechia,United Kingdom,United Kingdom,Canada
Call: International cooperation for research infrastructures (H2020-INFRASUPP-2014-2, 2014)
Start date: 2015-06-01
End date: 2019-11-30
Duration (months): 54.0
Total project cost (EUR): 1109863.75
EU funding (EUR): 1103613.75
Participants: 12
Project status: CLOSED

The IPAD-MD project addresses cooperation and coordination between the pan-European INFRAFRONTIER Research Infrastructure and complementary research infrastructures in America, Asia and Australia, contributing to the global effort of the International Mouse Phenotyping Consortium (IMPC). In order to increase the reach of INFRAFRONTIER, IPAD-MD will also reach out to complementary infrastructures and user communities in Africa. IPAD-MD will organise a series of workshops to achieve three major objectives: 1) Strengthen the coordination between the global research infrastructures. A particular focus of IPAD-MD will be to improve global access to the common resources created by INFRAFRONTIER and the IMPC and to align the scientific strategy with international research agendas. 2) Promote the involvement of the key international stakeholders to improve the resources and services offered by INFRAFRONTIER and established in the context of the IMPC. IPAD-MD will involve funders and program offices in the discussions about the future of the resources and services developed in INFRAFRONTIER and the IMPC. 3) Coordinate globally the development of innovative technology solutions for the improvement of the resources and services provided by INFRAFRONTIER and the IMPC. Importantly, the development of related quality control measures to sustain the high quality standards established in INFRAFRONTIER and in the IMPC, ensuring the reproducibility of results. The outcomes of the IPAD-MD workshops will be made available in reports and in key publications in scientific journals and on the INFRAFRONTIER and IMPC websites. A dedicated Communications & Dissemination Group will ensure the outreach to the wider scientific community and to the general public. The IPAD-MD will improve the quality and global accessibility of high-quality resources and services enabling the biomedical research community to tackle the global health challenges.

Keywords: systemic phenotyping,archiving,distribution,mouse disease models,global access to resources,engagement key stakeholders,innovative technology,communication and dissemination
Application of high power ultrasounds (HPUs) to improve the sustainability in meat TENderize and BRINe processes (TENBRIN)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-11-01
End date: 2017-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The meat segment represents the 20 % of the total turnover of the European food and drink market, with over €200 billion in 2012. However, the European meat industry has found to be less competitive than other international players in the global market. RI-LAVO proposes a solution for meat processing that will decrease costs while improving sustainability and quality in processed meats, without requiring the use of additives. After our previous experience in the FP7 project ULTRATENDER, we propose now the TENBRIN solution. TENBRIN is a High Power Ultrasounds (HPUs) based technology, non-invasive and safe, that improves meat processing and preservation in an energy-saving and cost-effective way. RI-LAVO´s value proposal consist on a HPUs equipment for brining and tenderizing different types of meat. The application of HPUs reduces the refrigeration time of tenderizing to 2 days (average time of traditional tenderizing: 20 days or more), and the brining time to 7 days (average brining time: 14 days). Therefore, TENBRIN can provide a reduction of 90% refrigeration time in tenderizing and 50% refrigeration time in brining greatly reducing the energy waste. Our users will be meat processors and gourmet restaurants. With the Tembrin solution, they will be able to improve the sustainability of their processes by decreasing processing times and energy waste, at an affordable cost for SMEs. In this phase 1 project we intend to do a feasibility study to address technical requirements to take our validated prototype to a ready-to-market product. We will also study the financial feasibility to determine the needed investment, that we estimate in €2M, and asses the profitability of the project. Finally, we will perform the commercial feasibility study and a business plan in order to better characterize the addressed market, assure our freedom-to-operate and define our IPR strategy and ensure our sales objectives, which we forecast to be €11,3M by 2022.

Keywords: ultrasound,tenderization,brining,meat,food processing