Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Modern Au-based Surfaces and Secondary ionisation for Mass Spectrometry Imaging of Small molecules (MASS2)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: CLOSED

Matrix-assisted laser desorption/ionisation (MALDI) mass spectrometry imaging (MSI) is increasingly used for clinical application. Based on untargeted, spatial chemical information, tissue samples can be analysed with superior density of information compared to conventional histology techniques. However, MALDI suffers from several significant limitations like strong ion suppression effects, inherently low ion yields limited to a few classes of polar to mid-polar analytes, and impeded detection of low-weight compounds. This crucially hampers a comprehensive analysis of complex biological samples. Strategies for post ionisation (PI) – most prominently MALDI-2 – significantly increase the ion yields for numerous mid-polar and polar compounds. Surface-assisted LDI (SALDI) uses photoactive surfaces, which feature specific ablation and ionisation that can majorly extend the range of detectable compounds and can be prepared in a superiorly homogeneous manner for SALDI-MSI. The proposed study aims to develop a novel means for extensive metabolome and lipidome analysis by SALDI-PI-MSI to overcome limitations of MALDI. Therefore, a new PI strategy coined Single-Photon Induced Chemical Ionisation (SPICI) will be combined with functionalised Au layers for comprehensive tissue characterisation of an extended polarity range with high mass resolution. The versatile software package rMSI will provides the computational means for the analysis of the complex measured data sets. We will apply our approach to human samples of bladder cancer tumour and achieve detailed monitoring of physiological processes in the cancerous tissue in unpreceded analytical depth. Newly identified biomarkers will help the urgent need for prognostic and diagnostic means for cancer. This comprehensive approach can be a massive generator of hypotheses for disease characterisation and foster the implementation of MSI into further fields of medical research and help to mature MSI in a multidisciplinary fashion.

Keywords: instrumentation
BuiLding-integrated User-Empowered flexiBIlity tRaDing (BlueBird)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Countries involved: Spain,Austria,Germany,Belgium,Poland,Denmark
Call: Smart grid-ready buildings (HORIZON-CL5-2024-D4-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 5740744.03
EU funding (EUR): 4999305.0
Participants: 16
Project status: SIGNED

BlueBird - BuiLding-integrated User-Empowered flexiBIlity tRaDing With the objectives of the Green Deal in mind, BlueBird aims to tackle the advantages derived from an increased use of flexibility assets in the electricity domain, leveraging AI and data solutions. BlueBird will deliver a comprehensive and validated toolset, to fully allow competitive adoption of buildings as energy flexibility assets, supporting smooth integration of services towards energy market players (i.e., TSO, DSO, aggregators) while maximally aligning with end-user's (i.e., building managers, occupants) requirements and acceptance criteria. BlueBird trials will take place in seven large-scale pilots in six countries: Spain, Belgium, Poland, Austria, Denmark, and Germany. These trials will include the validation of end-user and beneficiary acceptance using social-science methods. To foster replicability, BlueBird will offer a package of lessons learned and recommendations for future adoption. This will include suggestions for feasible win-win industrial partnerships and guidance on ecosystem sustainability. These ambitious objectives will be achieved by a consortium of experienced and highly complementary partners from research institutions, industrial sectors, public authorities, and NGOs across eight European countries.

Keywords: building user empowered flexibility trading ai based services for energy flexibilities
Fabrication of self-powered 2D MoS2 field-effect synaptic transistors actuated by triboelectric nanogenerators for neuromorphic application (FAST_TRIBONIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2027-03-31
Duration (months): 30.0
Total project cost (EUR): 226441.2
EU funding (EUR): 226441.2
Participants: 3
Project status: SIGNED

The development of neuromorphic devices and sensory networks has led to the creation of new systems similar to human brains. An artificial synapse can be used to perform various functions, such as long-term potentiation, depression, and spike-timing-dependent plasticity. Various types of synaptic electronics can be used to develop sensory neurons. Some of these include three-terminal devices and memristors with neuromorphic configurations. However, a particular device ideal for neuromorphic applications is a field-effect transistors based on the two-dimensional layered semiconductor. To reduce the energy consumption of artificial sensory neurons, a self-powered neuromorphic system can be developed that can operate on mechanical energy. This strategy can be useful in developing systems that are energy-efficient. This project aims to develop a functional and biological self-powered artificial synapse sensory system similar to the human somatosensory system. This will allow engineers to create self-powered electronic sensors, actuators, and communicators capable of handling biological intelligence. This project (FAST_TRIBONIC) involves the development of high-performance field-effect synaptic transistors with 2D MoS2 layered semiconductors and the construction of powerful triboelectric nanogenerators (TENGs) for the effective conversion of mechanical energy into electricity. Also, to develop an indigenous neuroelectric interface (artificial electronic skin) by integrating synaptic transistors and TENG during non-academic placement. By coupling TENG and field-effect transistors, a new field of tribotronics has been established for devices such as memory chips and tactile sensors. These technologies are expected to play a vital role in developing modern high-performance, energy-efficient self-powered wearable electronic devices.

Keywords: graphene,2d materials,triboelectric nanogenerator and thin film transistor,self powered devices,pvdf,polymer composite,graphene oxide,carbon nanofillers
Measuring the value of the Key Performance Indicators (KPI) of the 2Zero Partnership (LeMesurier)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Coordination and support actions
Partnership: 2ZERO (co-programmed)
Countries involved: Germany,Greece,Spain,France,Belgium,Austria
Call: Measuring road transport results towards 2ZERO KPIs (2ZERO Partnership) (HORIZON-CL5-2023-D5-01, 2023)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 1387320.25
EU funding (EUR): 1064295.25
Participants: 14
Project status: SIGNED

The 2ZERO Partnership KPIs are multiple and various, relating to the three-layer approach for the Objectives of 2ZERO, as expressed in its SRIA. This proposed CSA will determine a common framework for monitoring these multiple and various KPIs (including their sources, methods and reporting formats). It will generate values for the KPIs and their expected variation for the coming decade, based upon the results of the projects being conducted within the partnership and the assessment of the impact of these projects' results. The proposed CSA will support the identification and quantification of all interactions, impacts and effectiveness of the partnership within the road transport challenge. Furthermore, the proposed CSA will provide recommendations for development and analysis of the means of measurement and evaluation of the partnership within the road transport challenge. Finally, the CSA will disseminate and communicate its results to a wide range of stakeholders, throughout the road transport sector, but also across Member States and to the public in general, via a range of media and events. The consortium undertaking the proposed CSA represents many sectors of the road transport community from multiple European countries: it will be guided by a strong Advisory Board representing a broad range of vehicle manufactures, suppliers, RTOs, operators and infrastructure providers, as well as technology partnerships, joint undertakings and other representative organisations within Europe.

Keywords: road transport towards zero emissions partnership key performance indicators evaluation methods and measurements
Probing emergent phenomena in twisted WSe2 using THz-on-Chip spectroscopy (Twist-TOC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

Understanding how strong electron-electron correlations shape the behavior of quantum materials is important both for fundamental scientific discovery and future technological applications. For example, determining the role of electron correlations in unconventional superconductivity could allow scientists to design a room temperature superconductor. However, complicated materials and lack of in situ tuning parameters limit progress. Twisted WSe2 (tWSe2), like other van der Waals heterostructures , possesses in situ tunability of both doping and displacement field, providing a tractable model system with unprecedented control which may be described by a simple, single orbital triangular Hubbard model. In TwistTOC, I will investigate the strongly correlated dynamics and possible superconducting phase in moiré superlattices of tWSe2 using on-chip terahertz (THz) spectroscopy. The group of Dr James McIver at the Max Planck Institute for the Structure and Dynamics of Matter is the ideal host organization as they are pioneering the use of on-chip THz spectroscopy for investigating graphene-based vdW heterostructures. This technique uniquely probes the material response on the energy scale resonant with the emergent phenomena, containing a wealth of information, such as direct signatures of superconductivity. Using this platform, I will study the origin of the correlated insulating state observed at half-filling and characterize the frequency dependence of the metal to insulator transition. Next, I will investigate the nature of the possible superconducting phase in tWSe2. These studies will further our understanding of tWSe2, provide insight for theoretical models, and potentially shed light on unconventional superconductors with similar phenomenology. This project will provide me with the technical and leadership skills necessary to forge future research directions investigating the equilibrium and non-equilibrium THz response of a wide variety of quantum materials.

Keywords: terahertz spectroscopy,moir heterostructures,transition metal dichalcogenides
THz Industrial Mesh Networks in Smart Sensing and Propagation Environments (TIMES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Italy,Germany,France,Spain,Norway
Call: Wireless Communication Technologies and Signal Processing (HORIZON-JU-SNS-2022, 2022)
Start date: 2023-01-01
End date: 2026-03-31
Duration (months): 39.0
Total project cost (EUR): 6180161.0
EU funding (EUR): 5969258.0
Participants: 11
Project status: SIGNED

Future wireless networks are envisioned to support novel applications that require similar performance as wired networks in terms of data rate (Tbps), ultra-low-latency (well below 1 ms), sensing (e.g., mm-level localization accuracy), and reliability (e.g., 1 in a billion transmission error). The current 5G approaches have a hard time keeping up with such envisioned applications. TIMES addresses this problem by combining novel radio channel propagation measurements and modeling approaches, spectrally efficient and reliable communications at Terahertz (THz) spectrum bands with intelligent mesh networking protocols and smart sensing and shaping of the propagation environment through reconfigurable meta-surfaces. While the fundamental technologies developed will be applicable to different beyond-5G scenarios, TIMES will focus on an industrial setting, since many of the envisioned applications in this complex scenario (e.g., cooperative robots, predictive maintenance, real-time closed-loop control) require concurrent high performance, reliability, and sensing capabilities. To tackle the challenge, TIMES extends the state-of-the-art on three fronts: 1) Propagation channel measurements and characterization in THz bands, including measurement and modeling of meta-surfaces and electromagnetic leakage in complex scenarios; 2) Developing technological enablers for reliable THz communications (e.g., smart beam management, ultra-massive MIMO, THz-tailored PHY and MAC design, meta-surfaces, and new mesh-based architecture); and 3) Implementation of a THz mesh network prototype, including design and fabrication of both active (transceivers) and passive (meta-surface) nodes, to validate selected technological enablers developed in TIMES.

Keywords: thz communications,mesh networking protocols,smart propagation environments,integrated sensing and communications,design and fabrication of thz devices and meta surfaces,industrial scenarios
Dismantling and recycling Rare Earth Elements from End-of-life products for the European Green Transition (REEPRODUCE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Norway,Spain,Belgium,Slovenia,Netherlands,Poland,France,Germany
Call: Developing climate-neutral and circular raw materials (IA) (HORIZON-CL4-2021-RESILIENCE-01, 2021)
Start date: 2022-05-01
End date: 2026-04-30
Duration (months): 48.0
Total project cost (EUR): 12642498.75
EU funding (EUR): 10051919.5
Participants: 15
Project status: SIGNED

Europe's ambitious energy and climate goals are heavily dependent on critical raw materials such as Rare Earth Elements (REEs). The largest end-user of REEs is the permanent magnet (PM) industry for electric mobility and renewable energy technologies. The growth in those strategic sectors till 2050 is expected to increase the demand of Neodymium (Nd) and Dysprosium (Dy) by ~4 and ~12 times, respectively. However, Europe depends 100% on REEs imports and there are no market-ready substitutes. Despite the fact that significant amounts of EoL products containing REE-based PMs are collected in Europe, the current recycling processes do not allow PMs recovery, and therefore they are lost downstream. To face this challenge, the REEPRODUCE project aims at setting up, for the first time, a resilient and complete European REEs-recycling value chain, at industrial scale for the recovery of REEs at competitive cost compared to REEs primary production in China (at least 25% cheaper) with environmentally friendly and socially sustainable technologies. REEPRODUCE will capitalize on the knowledge generated in previous projects and aim to solve all remaining technical challenges along the value chain to construct pilots able to produce 70 t of PMs per year from variety of EoL products bearing Nd-based PMs. Additionally it will demonstrate the conversion of PMs extracted from many different EoL products into high purity Rare Earth Elements Oxide (REO)-mixtures and Rare Earth Elements Alloy (REA) that will be used in the manufacturing of new PMs with performances similar to those manufactured with virgin REEs-intensive materials. This project is formed by key partners covering the whole value chain, including EoL products recyclers, metal recyclers, manufacturers of equipment for recycling, producers of REEs-intensive material and PMs, developers of technologies successfully proven in previous projects, and experts in dissemination, communication and exploitation.

Keywords: rare earth elements,recycling,permanent magnets,waste electrical and electronic equipment,end of life vehicles,end of life products,critical raw materials,electric motors,hard disk drives
Acute pancreatitis therapy by RORα activation and FGF21 expression (PanRORα)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-11-01
End date: 2026-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Pancreatitis in humPancreatitis in humans is a cause of significant morbidity and mortality. Acute pancreatitis events have increased worldwide over the last 20 years at an average annual percent change of 3% and the economic burden is growing (1). Treatments for pancreatitis are currently limited. The overall mortality rate in acute severe pancreatitis is 10-15%. Thus, a specific treatment for pancreatitis is of great need. Recent reports suggest that FGF21 can ameliorate acute pancreatitis in mice. FGF21 is a protein which belongs to the fibroblast growth factor family and is predominantly produced and secreted by the liver. FGF21 is positively regulated by the RORα transcription factor. I will assess whether a RORα agonist that we identified by screening compounds that act against Non-Alcoholic Steatohepatitis (NASH) in mice, and which we found to increase FGF21 expression, can be used to treat acute pancreatitis (2). In addition, we will also investigate whether increased FGF21 expression can be used to prevent pancreatitis triggered by Endoscopic Retrograde CholangioPancreatography (ERCP). We established the Caerulein and alcohol induced pancreatitis models. In the Caerulein model we show [unpublished and patented (US Pending Patent 11,865,090)] significant therapeutic effects of a small compound that activates RORα. In this PoC, we intend to explore new compounds of the same family with better efficacy on FGF21 in vivo, and improve the treatment for acute pancreatitis. This study will establish FGF21 as a prognostic biomarker for acute pancreatitis in humans, by plasma ELISA and circulating free DNA. This PoC project has the potential to achieve a breakthrough therapeutic treatment for acute pancreatitis; one that is commercially viable, effective, avoids an immune response and has the benefits of a natural delivery, a natural chemical composition of FGF21, lower cost, higher availability, simple storage and overcomes the short half-life of synthetic proteins.
BioProtect Balloon Implant System – Enabling Safe Prostate Radiation Treatment even at extreme dosage (ProSpace)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 5501632.5
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Prostate is the 2nd leading cancer in men in the world, with more than 1.4 million men diagnosed every year globally. ~50% of men will be treated with radiation treatment. Radiation is a highly effective treatment; however, it has significant complications, mainly injuring the rectal tissue, approximate to the prostate treatment area. Up to 35% of the patients will experience rectal toxicity side effects such as bleeding, urinary, bowl and erectile dysfunction, damaging severely patient’s quality of life. There is a growing need for a solution that protects the rectum from the radiation field. Our soluton ‘ProSpace’ is a biodegradable medical grade copolymer (70:30 Poly L-Lactide-co-ε-Caprolactone) balloon spacer deployed in the prostate-rectum interspace. It creates a 1.8cm, symmetric distance between the prostate & rectum, allowing physicians to radiate prostate tumours & sparing healthy rectal tissue.

Keywords: medical devices,biodegradable materials for healthcare,balloon spacer,prostate cancer,health,novel bio materials,radiotherapy
NOVEL DOMESTIC BATTERY GRADE LITHIUM CARBONATE VALUE CHAIN FOR GREEN LIFE (Li4life)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Spain,Greece,Ireland,Belgium,United Kingdom,Germany,Finland,Czechia,Serbia
Call: Technologies for sustainable, cost-efficient and low carbon footprint downstream processing & production of battery-grade materials (Batt4EU Partnership) (HORIZON-CL5-2023-D2-01, 2023)
Start date: 2024-03-01
End date: 2027-02-28
Duration (months): 36.0
Total project cost (EUR): 6298614.26
EU funding (EUR): 6298614.25
Participants: 19
Project status: SIGNED

The fact is that the lithium deposits within the EU are associated with different mineralizations in solid host rocks, except from the lithium brines of South America and Australia. These mineralizations require a special approach when processing and purifying happen up to battery grade lithium carbonate. Li4Life proposal creates of an efficient technology for the extraction of lithium from poor or complex ores of underutilised deposits, as well as post-mining tailings, as the basis for the development of future clean energy. Reference objects is potentially viable lithium projects have been identified in Europe from Finland in the North, through Germany, Austria and Czech Republic in Central Europe, to Spain and Portugal in the South-West. To cover the needs of the EU Battery Industry, Li4Life is aim to contribute an ambitious objective to increase the EU domestic supply of local raw materials by at least 5% to upcoming 2030. This is possible by creating an innovative value chain for domestic lithium raw materials. Li4Life's pathway to this ambition - novel processing methods, and purification up to battery-grade lithium carbonate to overcome existing barriers, namely the lack of a sustainable social licence to operate (SLO) and compliance with strict EU environmental laws.

Keywords: lithium downstreams technologies lcc lca social assessment li value chain