Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Actionable metabolite supplements to improve treatment response in pancreatic cancer (ACT-PC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-05-01
End date: 2025-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The prognosis with metastatic pancreatic ductal adenocarcinoma PDAC is simply terrible, especially for those that do not respond to the chemotherapy, which is regarded as the standard therapy in most patients. More than half of the patients are non-responders and eventually pass away within months. It is therefore urgently needed to understand the differences among responder and non-responder patients, to develop alternative therapies that overcome the resistance and potentially further extend the survival for both groups. A recent hypothesis proposes the key role of microbiome and of the immune response in regard to tumor initiation, progression, as well as response to therapies. Diet, as a variable, introduces an additional layer of complexity, given its multifaceted impact on both the human microbiome and immune system, as our recent manuscript show. The metabolites produced by gut microbiota are influenced not only by diet, but also by a host of other factors. In ACT-PC, we propose the use of one or a combination of different microbiota-derived metabolites as a treatment to increase the efficacy of chemotherapy and at the same time to boost anti tumor immunity for PDAC patients. The overall goal of ACT-PC is to initiate the preclinical validation of specific microbiota-derived metabolites for improving treatment outcomes in PDAC patients. This project is designed to take our Technology Readiness Level from 2 to 4, enabling us to finalise the preclinical development within a subsequent EIC Transition and initiate clinical validation and development soon after. In implementing the project’s results we will leverage the PI’s unique network that includes commercial partners and patient organisations.
Towards Innovative Treatments and Management Of Surgical and Burn Wounds (INTROS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Slovenia,Italy,Spain,Belgium
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-11-01
End date: 2029-10-31
Duration (months): 48.0
Total project cost (EUR): 2520993.6
EU funding (EUR): 2275839.0
Participants: 12
Project status: SIGNED

The INTROS project, as multi- and interdisciplinary doctoral network, will develop diagnostic and prevention strategies for acute complex wounds that are at risk of infection. Infections represent a significant challenge, as they often require prolonged treatment and may even result in extended hospital stays. All this is associated with considerable burden to clinics and patients as well as financial costs. To address this issue, the doctoral candidates and consortium partners dedicate their efforts in creation of early diagnostic methods that can effectively detect infection and/or facilitate the direct application of advanced antimicrobial dressings and innovative formulations following burn or surgical procedures. Additionally, the (bio)materials will be designed to prevent inflammation, promote healing and regeneration, thereby reducing the risk of infection and its associated complications such as scarring and impairments. The developed systems will consist of innovative nano-/micro-sized delivery systems, biodegradable and-compatible electrical sensors or patches based on hydrogels, bacterial nanocellulose and polyurethanes as well as biologically active extracellular vesicles. This will be supported by extensive biocompatibility and efficacy testing in vitro, in vivo and especially in ex vivo wound models as well as in-depth physicochemical characterisation. Special emphasis will be on the scale-up to industrial levels and manufacturing towards GMP conditions already during the project’s lifetime. INTROS will contribute to bringing forward a new generation of young scientists by creating a research and training network for 8 Doctoral Candidates, equip them with multidisciplinary skills from biomaterials, nanotechnology, pharmaceutical chemistry and technology, biochemistry and material science. Combined with extensive complementary soft/transferable skills, INTROS will enable them to take leading roles in industry and academia in the European community.

Keywords: preventive wound treatment,anitinflammatory and antimicrobial dressings,burn and surgical wounds,particulate delivery systems,ex vivo models
Conjugative-killer plasmids, a novel antimicrobial alternative (CoKiP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

Targeted killing of pathogenic bacteria without harming beneficial members of the host microbiota holds promise as a strategy to cure disease and limit both imbalances in the microbiota and development of antimicrobial resistance. Recent work from the Unité de Plasticité du Génome Bactérien has demonstrated that genetic modules based on toxin-intein systems delivered by conjugation are highly effective antimicrobials agents, able to selectively kill Vibrio cholerae in mixed populations. In this line of work, the project described in this proposal aims at adapting the aforementioned system to other pathogens of clinical importance (Salmonella spp. Shigella spp and Klebsiella pneumoniae) by including new toxin modules whose expression depends on transcriptional factors that are exclusively present in the targeted bacteria. Additionally, to ensure an efficient dissemination and maintenance across the microbial gut population, we intent to engineer conjugative plasmids to be transferred and maintained between Enterobacteriaceae and Bacteroides, one of the main constituents of the gut microbiome. Once validated under laboratory conditions, the system will be assayed in a Caernorhabditis elegans model, either with the aim of eliminating a specific pathogen causing disease or as a probiotic agent against pathogenic colonization. The results obtained from these preliminary tests will direct the refinements needed for the generation of an effective tool against antimicrobial resistant pathogens in a real scenario.

Keywords: antimicrobial resistance bacterial toxins inteins plasmid biology conjugation genetic engineering
Consolidating Research and Policy along the Cognitive Computing Continuum (NexusForum.EU)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Coordination and support actions
Countries involved: Sweden,Spain,Ireland,Switzerland,Japan,Korea, Republic of
Call: Coordination and Support of Cognitive Computing Continuum research and policy (CSA) (HORIZON-CL4-2023-DATA-01, 2023)
Start date: 2024-01-01
End date: 2026-06-30
Duration (months): 30.0
Total project cost (EUR): 1999500.0
EU funding (EUR): 1999500.0
Participants: 7
Project status: SIGNED

The transition from H2020 to HE reflects an ongoing mega-trend in ICT: the convergence of Cloud, Edge, and IoT. This tendency has significant impact in Europe at scientific, technological, socio-economic, and geopolitical levels, as these traditionally separated fields are now converging into a much larger ecosystem now sharing a number of common challenges and key priorities. Upcoming RIAs should integrate and capitalise on ongoing efforts, with a vital aspect for Europe in this whole process being to successfully combine and consolidate the technology priorities defined by EU industry through the “European Alliance for Industrial Data, Edge and Cloud” and the advancements that the IPCEI-CIS will provide in the coming years. This transition and the move of the whole community of EC-funded projects and related initiatives towards a closer cooperation with industry is what the NexusForum.EU project aims to support and facilitate by focusing on consolidating research and policy along the Cognitive Computing Continuum, something crucial to effectively expand what the ongoing CSAs (particularly EUCloudEdgeIoT) are working on, thus providing a clear, consistent vision for future research and innovation topics in this EU strategic area. NexusForum.EU, through its unique consortium, will be able to effectively undertake a number of crucial activities, such as producing annual research roadmaps and policy recommendations; fostering collaboration between industry and academia; creating solid links with the IPCEI-CIS and the “European Alliance for Industrial Data, Edge and Cloud”; collaborating with past and present RIAs in order to promote a diverse EU research and innovation community; identifying relevant issues such skills development gaps; analysing the relationship with crucial topics such as Open Source and Open Standards; and engaging with forward-looking research and innovation communities and strategic initiatives outside Europe (starting with Japan & South Korea).

Keywords: cloud edge iot cognitive computing continuum
PUBLIC ENGAGEMENT IN RESEARCH INFRASTRUCTURES FOR MISSION CANCER: MANAGING COMPLEXITY OF EMERGING TECHNOLOGIES (PERIFORMANCE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Other missions
Destination: Other missions
Action type: Research and Innovation actions
Countries involved: Austria,France,Spain,Latvia,Malta,Belgium,Estonia,Netherlands,Greece
Call: Experimental local action for EU missions: knowledge institutions as focal points of transdisciplinary research and innovation activities with European outreach (HORIZON-MISS-2024-CROSS-02, 2024)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 2362348.75
EU funding (EUR): 2362348.75
Participants: 13
Project status: SIGNED

Enhancing stakeholder engagement in cancer research is essential for advancing the relevance, impact, ethicality, and equity of research outcomes. Engaging patients, caregivers, clinicians, researchers, and community representatives in the research process enables synergistic optimisation of potential impact. The PERIFORMANCE project focuses on promoting local action for Mission: Cancer and aims to leverage the federated biobanking domain as focal points for transdisciplinary research and innovation activities with European outreach. Biobanks, particularly those using population cohorts dedicated to cancer research, set the sampling frame to explore best practices and identify needs in the context of stakeholder engagement. PERIFORMANCE goes beyond the standard patient/public involvement (PPI) practices and adopts a quadruple helix perspective on stakeholders, which includes patients and donors, research and healthcare professionals, industry partners, and policymakers. By addressing the use of AI and EHDS in biobanking within cancer research, the project aligns with the call’s objectives to foster systemic solutions at a time of major sociotechnical transformations. Its emphasis on ethical, legal, and societal dimensions resonates with the call’s focus on ensuring that technological advancements contribute positively to public trust and societal well-being. PERIFORMANCE prioritises broad dissemination and training, ensuring its outcomes are widely accessible and scalable. Its approach supports the call’s goal of achieving broad, lasting impact across Europe, reinforced by an open call for bottom-up engagement exercises in diverse contexts, considering local or regional needs. PERIFORMANCE will contribute to the EU’s Mission: Cancer by fostering informed participation among stakeholders, enhancing the ethical use of new technologies and boosting the relevance and equity in public policy and research outcomes.

Keywords: cancer,public engagement,stakeholder engagement,innovation,science and society,ehds,artificial intelligence,biobanks,patient organisations,open calls,local,cancer mission,elsi
Nocturnal Chemistry in a Today's European Metropolis (NOCTEM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

Urban air pollution has a great impact on both climate and human health. As policies increasingly focus on the reduction of pollutant emissions (e.g. nitrogen oxides, NOx), the evolving role of nocturnal atmospheric oxidation processes in urban air quality remains poorly understood. Even though the nitrate radical (NO3), formed from oxidation of NOx by ozone, is a powerful oxidizing agent at night, its impact on contemporary and future urban atmospheres is not yet well characterized. Model calculations as well as field measurements in China and the US imply that NO3 production rates significantly increase during the evolution NOx abatement acts. Nevertheless, there have been no recent assessments of NO3 mixing ratios in European cities during the night, especially considering the EU's latest mitigation efforts. The NOcturnal Chemistry in a Today's European Metropolis (NOCTEM) project aims to illuminate this neglected dark side of air pollution by combining field measurements of NO3 with means of cutting-edge absorption spectrocopy techniques atop a central tower in Paris, France, with chamber studies under controlled present and future NOx emission scenarios. The results from these studies are going to be implemented in the CHIMERE model used to predict the air quality in Île-de-France. The applicant offers expertise in nocturnal atmospheric chemistry, spectroscopy, and field work. This research project will not only broaden the applicant's experience and research skills but also strengthen the professional network, thereby advancing the long-term goal of securing a permanent researcher position.go

Keywords: nitrogen oxides,atmospheric oxidation of volatile organic compounds,nocturnal processes,urban environments
NEXT GENERATION TOOLS FOR GENOME-CENTRIC MULTIMODAL DATA INTEGRATION IN PERSONALISED CARDIOVASCULAR MEDICINE (NextGen)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Netherlands,Finland,Italy,France,United States,Germany,Belgium,Switzerland,United Kingdom,Sweden,Portugal
Call: Better integration and use of health-related real-world and research data, including genomics, for improved clinical outcomes (HORIZON-HLTH-2023-TOOL-05, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 7869618.75
EU funding (EUR): 7869617.5
Participants: 22
Project status: SIGNED

Healthcare is the fasted growing EU27 expenditure. Personalised medicine, comprising tailored approaches for prevention, diagnosis, monitoring and treatment is essential to reduce the burden of disease and improve the quality of life. Integration of multiple data types (multimodal data) into artificial intelligence models is required for the development of accurate and personalised interventions. This is particularly true for the inclusion of genomic data, which is information-rich and individual-specific, and more routinely available as the cost of sequencing continues to fall. Multimodal data integration is complex due to privacy & governance requirements, the presence of multiple standards, distinct data formats, and underlying data complexity and volume. NextGen tools will remove barriers in data integration several cardiovascular use cases. NextGen deliverables will include tooling for multimodal data integration and research portability, extension of secure federated analytics to genomic computation, more effective federated learning over distributed infrastructures, more effective and accessible tools for genomic data analysis; improved clinical efficiency of variant prioritisation; scalable genomic data curation; and improved data discoverability and data management. A comprehensive gap analysis of the existing landscape, factoring ongoing initiatives will ensure NextGen deliverables are forward-looking and complementary. NextGen embedded governance framework and robust regulatory processes will ensure secure multi-jurisdictional multiomic multimodal data access aligned with initiatives including “1+ Million Genomes” and the European Health Data Space. Several real-world pilots will demonstrate the effectiveness of NextGen tools and will be integrated in the NextGen Pathfinder network of five collaborating clinical sites as a self-contained data ecosystem and comprehensive proof of concept.

Keywords: cardiovascular medicine,genomics,federated learning,data space,data oriented architecture
OPTAM: Intelligent Materials Acceleration for Additive Manufacturing Excellence (GAL-OPTAM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Generative Alchemy Ltd (GAL) is a deep-tech company transforming the future of metal additive manufacturing (AM) through data-driven alloy innovation. Our mission is to eliminate the bottlenecks in alloy development—traditionally slow, costly, and environmentally intensive, by enabling rapid, sustainable, and intelligent material design. Leveraging advanced AI, proprietary datasets, and world-class expertise, we empower engineers to develop and deploy custom alloys and print strategies in months rather than years, redefining production speed and flexibility across aerospace, automotive, energy, healthcare, and defence. Founded in 2021 in London by three University of Cambridge alumni, GAL brings together over 50 years of combined experience in materials science, manufacturing, and AI. Our proprietary cloud platform, OPTAM (Optimisation for Additive Manufacturing), integrates AI-powered microstructure recognition, machine parameter optimisation, and generative alloy discovery. Unlike traditional approaches, OPTAM predicts how material composition and process variables influence part performance—reducing time-to-market by up to 90%. Since launch, GAL has delivered a TRL6 MVP of OPTAM, secured pilot customers including Protolabs and Birmingham City University, and attracted interest from GE Additive, Leonardo, and Imperial College. Our growing team comprises PhD-level engineers, data scientists, and AM specialists, supported by global advisors and strategic partners. Our pilot with Protolabs has already yielded measurable process improvements, while academic collaborations continue to enrich our proprietary multi-material datasets. GAL is building the foundational infrastructure for next-generation industrial materials. With EIC Accelerator support, we will scale our impact and help Europe lead in sustainable, high-performance manufacturing.

Keywords: additive manufacturing,3d printing,materials discovery,process optimisation,saas,cloud platform,artificial intelligence,generative alchemy,optam,digital thread,advanced metal alloys
Capacitation of Quantum-Entangled NV-Center Sensing (C-QuENS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Spain,Belgium,Germany,Czechia
Call: Next generation quantum sensing and metrology technologies (RIA) (HORIZON-CL4-2023-DIGITAL-EMERGING-01-CNECT, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 2999990.0
EU funding (EUR): 2999990.0
Participants: 5
Project status: SIGNED

C-QuENS is an innovative research project aimed at advancing the field of quantum sensing by developing the next generation of NV-centre-based quantum sensors with quantum entanglement-enhanced performances. To achieve this goal, C-QuENS brings together six world-leading experts from four European countries who have made pioneering contributions to this research field that are essential for the realisation of the C-QuENS research vision. The project will focus on developing novel sensing protocols based on engineered correlated quantum spin states, such as entangled states and dynamical phase transitions. These protocols will outperform current quantum sensing scenarios based on independent spins in terms of sensitivity and precision. The development of these protocols will build on strong theoretical support with the development of quantum control methods, advanced signal processing protocols and experiment modelling, optimisation and analysis. C-QuENS will conduct laboratory demonstrations of these protocols using multi-qubit quantum registers undergoing magnetic dipolar interaction to create multi-qubit entanglement and many-body dynamics. In addition, the project aims to bridge the knowledge and technical gaps to implement laboratory prototypes of NV-based quantum devices that can find application in a wide range of fields as diverse as semiconductor testing or medicine. These objectives will leverage pivotal advances in diamond quantum-capable materials, including NV growth control and surface treatments. The outcomes of C-QuENS will be disseminated to the scientific community, industry, and society to promote the adoption of these technologies and maximize their impact in basic science, material manufacturing, microelectronics, healthcare, and metrology. The project will also contribute to training quantum-literate physicists and engineers and to consolidate the European supply chain on diamond quantum sensors, crucial to maintain Europe's competitiveness.

Keywords: quantum sensing,entanglement,nitrogen vacancy centre,diamond,spin,colour centres