Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Emitter-mediated Photon-Phonon InteraCtion (EPPIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

This action, “Emitter-mediated Photon-Phonon InteraCtion” (EPPIC), will contribute to the research areas of quantum computing and quantum sensors. These are key areas of the quantum technologies flagship initiative, which has the goal of establishing Europe as a leader in the second quantum revolution and its future industrial exploitation. The focus of EPPIC is on III-V semiconductors due to their compatibility with industrial nanofabrication. Implementing quantum bits in such semiconductors typically relies on the optical control of single spins in local potential traps (expertise of the host). These traps are called quantum dots (QDs). In order to carry out computations using QDs their behavior needs to be well controlled. Continuous interactions with an uncontrolled environment have a “distracting” influence on the QD and lead to a phenomenon known as decoherence. Overcoming decoherence is a major challenge in developing quantum technologies. In this action novel optomechanical and purely mechanical nanostructures will be designed and realized in order to shield QDs from some of the light (optics) and sound (mechanics) in their environment (expertise of the applicant). Once achieved, resonators can be designed that make the QDs interact strongly with specific frequencies of light and sound. The aim of EPPIC is to demonstrate that these nanostructures can manipulate the optical and spin-dynamics of a QD and that optical control of the QD can be used to manipulate the state of an isolated mechanical resonator. These accomplishments will lay the ground work for future projects: to create nonlinear elements for optomechanics; mediated QD-QD interaction by a common mechanical mode; achieve ground-state cooling of a mechanical resonator via optical control of a single QD; and using the optical control of QDs to prepare non-classical mechanical states. Thus giving the applicant an excellent starting point to conduct high-impact research in his future scientific career.

Keywords: quantum dots,optomechanical and mechanical crystals,spin dynamics,resolved sideband regime,photon phonon interaction,and quantum acoustics
Device oriented molecular spin filter based interfaces (DELICE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2020-02-16
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

We live in a constantly changing society in which information and communication are at the basis of our economy. To keep progressing is essential to investigate new feasible ways to control and manipulate information in order to develop faster, smaller and less consuming devices. Organic Spintronics has emerged as a promising field to develop low-cost, mechanically-flexible and multi-functional devices in which information is carried not only by the charge but also by the spin of electrons. However, the injection and transport of the spin information through a device remains challenging, being organic/inorganic interfaces key to overcome this limitation. DELICE addresses the interface engineering in organic spintronics, aiming to profit from unique molecular capabilities for the development of highly performant chemically-tailored organic spintronic devices. In particular, DELICE focuses on exploiting the predicted spin filtering behavior of some organometallic molecules to obtain highly spin-polarized interfaces, enhancing the spin injection from ferromagnetic surface or even creating spin-polarization on non-magnetic metal surfaces. These so-called spinterfaces will be implemented in organic spintronic devices, spin valves, in order to determine the impact they have on the device performances. While organics have been mainly used as passive spacers in such devices, DELICE plans to go beyond the state of the art by actively exploiting the molecule’s spin filtering capability to improve device performances. A thorough characterization of the spinterfaces properties together with their implementation in real devices will provide us with valuable knowledge about the role of interfaces in devices. The technological potential of such a result represents a major step towards the realization of competitive organic nanodevices. The ultimate goal of DELICE is offering an interdisciplinary training to a promising young female researcher.

Keywords: spinterface,spin transport
PlateLys: The innovative human platelet lysate especially designed to maximize the effectiveness of cell-based therapies (PLATELYS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Iceland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cellular therapies making use of stem cells, engineered immune cells or engineered tissue represent an unprecedented and fast-growing therapeutic area. To date, 14 cell therapies have been approved by the FDA. However, the cells being implanted to the patient need to be cultured in vitro at some point under highly specific and controlled conditions. One of these conditions –indispensable to culture any type of isolated cell in vitro– involves using animal-derived serum as a source of hormones and growth factors to mimic cells' native environment. It is estimated 1.5 million calf fetuses are inhumanely sacrificed to collect serum. This leads (among other negatives) to endanger patient's safety, because of cross-species immune reactions (which may be lethal) and the transmission of animal borne diseases (e.g. the mad cow disease). PlateLys is PLATOME´s solution to develop and produce a remarkable human-based serum substitute fulfilling all the requirements to culture cells. PLATOME is an award-winning Icelandic start-up created in 2016 to leverage the substantial know-how on human platelet lysates (hPL) production from its founders. PlateLys is the only hPL combining: a viral-inactivated hPL ensuring the highest safety profile for patients and operators; a clinical-grade lysate with standardized quality control and GMP certified amenable for research and clinical set-ups; a powder formulation providing maximal flexibility, especially on applications that were nonviable previously. The market of sera supplements will be worth €1.14 billion by 2025 (CAGR of 8%, period 2017-2025) with a large shift to hPL use ongoing. Through the PlateLys project we seek to complete the optimization and scale-up production, starting commercialization activities in Europe by 2021. By 2025, we will have generated €5.52 million in turnover and increase our staff by 300%. PlateLys will allow us to expand our portfolio of cell-oriented products, thanks to our patented production technology.

Keywords: human platelet lysate,animal serum free,cellular therapies,cell culture,cell sera,biotechnology
Political prisoners: a transnational question in 19th century Italy (PoliticalPrisoners)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2022-09-30
Duration (months): 36.0
Total project cost (EUR): 251002.56
EU funding (EUR): 251002.56
Participants: 2
Project status: CLOSED

This research project is a transnational historical investigation which examines the international role and representations of Italian political prisoners during the 19th century. Its goal is to investigate how and to what extent political prisoners were key figures not only in the construction of an Italian nationalist discourse, but equally in the foreign understanding of and commitment for the Italian Risorgimento. Moreover it will delineate how humanitarian debates operated in the commitment towards a national political cause. The project will place political detainees beyond legal and political history, and insert them in the context of the new questions raised by transnational and cultural history, and by the history of humanitarianism. I argue that political prisoners acted as political and patriotic agents at home as well as abroad. Not only did the experience of imprisonment influence the detainees’ political activities and identities, and help to create a sense of national community; but it influenced the representation of the Italian national movement abroad. The project will offer a new approach in studying political imprisonment emphasising its international and humanitarian dimension and will challenge the current state-of-the-art, highlighting how political prisoners were an international concern already in the 19th century. Finally the research will help to understand the historical evolution of a European sensitivity and a commitment towards political detainees, refugees and people persecuted for political opinions and the evolution of international protection and humanitarian discourses. There is a running thread between these historical issues and questions concerning political prisoners in the world today and the international awareness and concern about them. The research project is a multi-lingual and multi-archival study that will employ an interdisciplinary and a transnational approach.

Keywords: political prisoners,transnational history,19th century,europe,repression,nationalism,solidarity,humanitarianism
Bi(III)/Bi(V) Redox Catalysis for Organic Synthesis (BiREDOX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

The continued use of non-earth abundant and toxic metals as catalysts represents a major challenge in catalysis that must be addressed if true sustainable processes are to be developed. In this regard, the development of new low-cost and non-toxic catalysts would be highly desirable with significant impact to the environment and ultimately, our society. To this end, bismuth represents an attractive alternative for the development of catalytic alternatives that secure sustainable and environmentally friendly approaches for organic synthesis. Despite the wide range of bismuth salts capable of performing organic transformations, their ability to participate in catalytic redox processes is largely unknown. Hence, the major reason for this underdevelopment is the requirement of strong oxidants to achieve a higher oxidation state at the metal center, rendering a catalytic cycle unfeasible. Thus, this project aims at the rational design of novel bismuth complexes to be engaged in catalytic Bi(III)/Bi(V) redox processes, which will represent an unprecedented strategy for organic synthesis. The research proposal presented herein relies on the design of strained Bi complexes to unlock the use of N-fluoro/trifluoromethyl salts and of aryliodonium and diazonium species, to serve as mild oxidants for Bi(III) centers. In addition, reductive elimination from Bi(V) will also be studied in detail to fully elucidate the basic steps of a Bi(III)/Bi(V) redox cycle. Additionally, the ultimate goal of this proposal is the implementation of such bismuth complexes as catalysts in organic synthesis, thus opening up new possibilities to explore a new chemical space. Thus, this project aims to provide a greener alternative to the scarce and expensive second- and third-row transition metals typically used in catalysis, particularly focusing on both their replacement for bismuth salts and the discovery of novel reactions and selectivities previously unknown.

Keywords: mechanistic studies,oxidative addition,reductive elimination,transmetalation
TRanscriptomic analysis improving models to predict microbial SafeTy of ready-to-eat foods (TRuST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Listeria monocytogenes (Lm) is a potentially deadly pathogen with the ability to grow in a wide range of ready-to-eat (RTE) food products. This pathogen is of major concern for food stakeholders, as numerous product recalls from markets and an increasing number of outbreaks are occurring in Europe. In this economic and public health context, more research is urgently needed to understand and prevent Lm growth in RTE foods. TRuST is about creating a robust growth model to predict and manage Lm growth in RTE foods, especially lightly preserved and RTE seafood where contamination with Lm is particularly high. While some mathematical models exist today for this purpose, there is a general consensus that more accurate models are needed. For example, models incorporating gene expression (GE) data and growth variability (GV) between different isolates. My approach will be to combine GE and GV data in the existing and extensively used Lm growth model developed at DTU Food (host institution). This will be obtained by using RNA sequencing techniques and innovative mathematical modelling approaches. The newly generated models will be freely available as part of the Food Safety Spoilage Predictor (FSSP) software, developed at DTU Food. FSSP is today used in more than 125 countries by more than 10,000 users, benefitting the food industry, authorities and consumers worldwide. The team at DTU Food has a solid experience with Lm in RTE foods, food safety modelling, and software development. The secondment supervisor (UZH) is an expert in the genomics and transcriptomics of Lm. I have large experience in predictive microbial modelling and analytical food microbiology techniques. With the MSCA fellowship, I will benefit from the complementary expertise at DTU Food and UZH and facilitate collaboration between the two institutions. Moreover, this fellowship will be instrumental to prepare me as an expert scientist capable to assist the resolution of future food safety issues in Europe.

Keywords: predictive microbiology,transcriptomics,food safety
PAssive Systems: Simulating the Thermal-hydraulics with ExperimentaL Studies (PASTELS)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Nuclear safety
Action type: Innovation actions
Countries involved: Germany,Germany,Germany,Italy,Finland,Switzerland,France,France,Czechia
Call: Innovation for Generation II and III reactors (NFRP-2019-2020, 2019)
Start date: 2020-09-01
End date: 2024-02-29
Duration (months): 42.0
Total project cost (EUR): 3801457.5
EU funding (EUR): 2993262.76
Participants: 11
Project status: SIGNED

PASTELS aims to significantly increase the knowledge within Europe of innovative passive systems, namely SACOs and CWCs, and the ability of several European system and CFD computational codes to be able to accurately model key phenomena such as natural circulation loops and condensation. This is very challenging due to their very specific properties, i.e. small driving forces working against high resistive forces which are specific to the concept of these technologies. Given the growing use of the SACO and CWC technologies in non-European NPPs, it is essential, especially with the foreseen future use of Small Medium Reactors (SMR) that the European nuclear community is able to adapt its current numerical tools to this promising technology. Extensive experimental testing (SET, CET and integral experiments) with representative operating conditions on semi-industrial full scale test facilities (PKL facility [DE] and PASI facility [FI]) will provide essential data to support the improvement of the numerical activities. Existing data from PERSEO and HERO-2 facilities will also be used. The numerical and experimental activities will be conducted in an integrated step-by-step approach. PASTELS will investigate improvements to models, novel methodologies for the coupling of system and CFD codes working at different scales. Additionally, important knowledge on the behaviour of the SACO and CWC will be captured through the observation of their behaviour during the test campaigns. Different and similar computational codes will be used by the partners in order to be able to benchmark and compare the different results obtained, understand the causes and propose strategies to improve them. All project results will feed into extensive methodology guidelines and a roadmap to achieving licensing and implementation of these innovative passive system technologies in future European NPPs.

Keywords: innovative passive systems,safety demonstration,design,reliability,saco,relevant experimental data,system and cfd code,benchmark,guidelines,code coupling methodologies
Engineering Interdependence - A Window into the Evolution of the Human Mind (ENGINE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Switzerland
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The human mind is very similar to that of other great apes, yet also strikingly different, and a vast body of research converges on one conclusion: this gap is fundamentally social. Moreover, it emerges early in ontogeny, reflects the distinctly human neurochemical profile, and is characterized by physiological, hormonal, and behavioural synchronicity. But why did this gap evolve in the first place, and why was it us, rather than any of the other great apes, who diverged so dramatically and evolved this unique socio-cognitive niche? Multiple proposals stress interdependence as the key factor during human cognitive evolution, but testing this idea empirically remains a major challenge for the field. ENGINE sets out to do so, by proposing a process-oriented working model of human cognitive evolution in which interdependence takes centre stage, and testing it by engineering interdependence in the marmoset monkey, the emerging next-generation model for human social behaviour. I will thus produce an inter-dependent lineage of marmosets that will only be able to overcome daily challenges (i.e. finding food, defence against out-groups and predators, securing comfort) via mandatory cooperation, whereas an in-dependent lineage will have to overcome these challenges via individual effort. I will investigate downstream effects of this experimentally induced variation in interdependence on neurochemistry, synchronization at various levels, and cognitive outcomes. I will examine both immediate and long-term effects, when mandatory interdependence is experienced during ontogeny and over generations of animals. I will complement this engineering part by studies with human children, and validate it with wild marmosets. ENGINE thus allows us for the first time to comprehensively assess how interdependence affects socio-cognitive functioning in nonhuman primates, which brings us a crucial step forward in understanding how and why the human mind evolved.

Keywords: joint action co representation,synchronicity,cognitive positivity bias,conformity,comparative and developmental psychology,evolution of the human mind,nonhuman primates,marmoset monkeys,cooperative breeding,oxytocin,interaction engine,hunter gatherers,interdependence,obligate cooperative foraging
Virtual hot Forming and Mechanical design of beta Titanium alloys: towards a sustainable process (ViFoMeTi)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-03-01
End date: 2024-09-20
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

The experienced researcher Bernardete Coelho, doctor in Mechanical Engineering from the University of Aveiro (Portugal), aims at leading research activities on the numerical modelling of the thermo-mechanical behaviour of β-metastable titanium alloys. Such activities will be carried out in Université Bretagne Sud (France) under the supervision of Prof. Sandrine Thuillier. Advanced materials such as titanium alloys are considered as technological key enablers in societal challenges and a key factor in technological solutions, as they determine the process, the mechanical properties and the service life of an object. Regarding β-titanium alloys, they are more and more used in the biomedical and aeronautic fields and the modelling of their thermo-mechanical behaviour will become an enabling technology in order to perform forming at warm and elevated temperatures. Given the huge interest in the thermo-mechanical behaviour of lightweight β-titanium alloys, one objective of this project consists in its investigation and numerical modelling over a large range of temperatures. It is also intended to include the modelling of the occurrence of plastic instabilities in β-titanium alloys, for a biphasic material, i.e. titanium molybdenum with several compositions as well as an industrial material. Moreover, the technological part of this project aims to validate the thermo-mechanical models to the case of hot forming of a β-titanium alloy. Then, the final objective of this project is to perform a fast eco-audit, using eco-indicators, for different scenarios including hot forming and heat treatment for β-titanium alloys. Additionally, a business plan for a promising application will be developed. As a global overview, this project deals with the virtual forming and mechanical design of parts made out of β-titanium alloys for a large range of compositions, based on the modelling of the thermo-mechanical properties (up to rupture) of such alloys in a large range of temperatures.

Keywords: titanium alloys