Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DARPin Targeted Magnetic Hyperthermic Therapy for Glioblastoma (DARTRIX)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: United Kingdom,Switzerland,Germany,France,Germany
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-03-01
End date: 2017-02-28
Duration (months): 60.0
Total project cost (EUR): 7754338.43
EU funding (EUR): 5998134.0
Participants: 8
Project status: CLOSED

DARTRIX, ‘DARPin Targeted RX (therapy)’ is a multidisciplinary collaborative project that will develop high-affinity protein scaffolds to create a new generation of targeted therapeutics for the treatment of glioblastoma. There is great need; glioblastoma is virtually incurable and most patients die within 12 months of diagnosis. DARPins are small, non-immunoglobulin human protein scaffolds that bind specific targets with exceptionally high-affinity. DARPins are amenable to GMP production and to scale-up. They are remarkably stable, even at high temperatures and they can be engineered to incorporate additional favourable properties to target glioblastoma cells with exceptionally high affinity. The new DARPins will be coupled to dextran-coated iron oxide nanoparticles, such as ferucarbotran or nanomag-MIP, which has been used clinically as a contrast agent for Magnetic Resonance Imaging (MRI). These ‘particles’ are safe to use in patients and are traceable within the body. When stimulated by an appropriate alternating magnetic current, the particles generate heat that can kill cancer cells very effectively. The conjugation of DARPins with ferucarbotran or nanomag-MIP (DARTRIX particle) leads to a potent therapeutic by delivering targeted hyperthermia to glioblastoma. In addition, DARTRIX particle will be created economically, exploiting the fact that DARPins can be produced to GMP in gram quantities using E. coli. The DARTRIX particles will target to glioblastoma cells by virtue of the high affinity and specificity of DARPins and the particles will remain in place when heated. By using DARPins to target the DARTRIX particle to tumour cells before application of the magnetic current, it should be possible to generate toxic heat specifically in the tumour. The consortium has all the skills and knowledge to develop DARPins from bench-to-bedside for glioblastoma treatment. This DARTRIX particle will pioneer targeted hyperthermic cancer treatment of glioblastoma in an innovative adaptive first-in-man trial, using direct injection or convection enhanced delivery to localise the particles to the tumour.

Keywords: darpins,scaffold,affinity,cancer,glioblastoma,gmp,scale-up,targeted therapy,magnetic hyperthermia,egfr1,spion,phase i/ii trial,bench-to-bedside,immunogenicity,proof-of-concept
Organic Zeolites (ORGZEO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Materials and Synthesis
Countries involved: Germany
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

This ERC-StG proposal, OrgZeo, outlines a strategy for the synthesis, processing and application of charged, porous, covalent organic net- or frameworks, denoted “organic zeolites”. In analogy to their inorganic counterparts, organic zeolites should fulfil the following criteria: a) the material will possess small (nm-range) and accessible pores and consequently very high surface areas and pore volumes and b) the ionic group will be a supporting part of the network, while the counterions, needed to balance the net-charge will on the other hand be mobile and thus exchangeable. However, in contrast to common inorganic zeolites c) the entire or at least main parts of the material will be composed out of covalently bound organic matter, justifying the naming “organic zeolite”. The organic character of the samples will allow introduction of permanent and reversible, positive or negative network charges. The target of this proposal is the introduction of the next generation of microporous materials combining the best properties of zeolites, MOFs, microporous polymers and polyelectrolytes. It is envisaged that the special architecture and chemical structure of the organic zeolites will further add entirely novel properties to these materials.

Keywords: porous materials,organic frameworks,zeolites,processing,hydrogen storage,heterogenous catalysis
Studying the gas around galaxies with the Multi Unit Spectroscopic Explorer and hydrodynamical simulations (GASAROUNDGALAXIES)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Universe sciences
Countries involved: Netherlands
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-09-01
End date: 2017-08-31
Duration (months): 60.0
Total project cost (EUR): 1496400.0
EU funding (EUR): 1496400.0
Participants: 1
Project status: CLOSED

Gas accretion and galactic winds are two of the most important and poorly understood ingredients of models for the formation and evolution of galaxies. We propose to take advantage of two unique opportunities to embark on a multi-disciplinary program to advance our understanding of the circumgalactic medium (CGM). We will use MUSE, a massive optical integral field spectrograph that we helped to develop and that will be commissioned on the VLT in 2012, to study the CGM in both absorption and emission. We will use 200 hours of guaranteed time to carry out deep redshift surveys of fields centred on bright z≈3.5 and z≈5 QSOs. This will yield hundreds of faint galaxies (mainly Lyα emitters) within 250 kpc of the lines of sight to the background QSOs, an order of magnitude increase compared to the best existing sample (bright, z≈2.3 galaxies). This will allow us to map the CGM in absorption in 3-D using HI and metal lines and to identify, for the first time, the counterparts to most metal absorbers. MUSE will also enable us to detect Lyα emission from the denser CGM (also using another 300 hours of guaranteed time targeting deep HST fields) and thus to directly explore its connection with galaxies and QSO absorbers. We will use the new supercomputer of the Virgo consortium to carry out cosmological hydro simulations that contain 1-2 orders of magnitude more resolution elements than the largest existing (spatially adaptive) runs. We will use the results of our previous work to guide our choice of parameters in order to obtain a better match to the observed mass function of galaxies. In parallel, we will carry out a complementary program of zoomed simulations of individual galaxies. These will have the physics and resolution to include a cold gas phase and hence to bypass much of the "subgrid" physics used in the cosmological runs. Both types of simulations will be used to study the physics of gas flows around galaxies and to guide the interpretation of our observations.

Keywords: galaxy formation,intergalactic medium,qso absorption lines,integral field spectroscopy,numerical simulations
Optimisation of Transport Solutions for Compressed Hydrogen (DELIVERHY)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Germany,France,United Kingdom,Norway,Denmark
Call:  (FCH-JU-2010-1, 2010)
Start date: 2012-01-01
End date: 2013-12-31
Duration (months): 24.0
Total project cost (EUR): 1249565.6
EU funding (EUR): 719502.0
Participants: 6
Project status: CLOSED

Compressed hydrogen trailers are cost efficient for near term distribution. However, with the currently used 20 MPa trailers the supply of larger refuelling stations would result in multiple truck deliveries per day, which is often not acceptable. In order to increase the transported quantities, lighter materials and higher pressure must be adopted. The cost increase of the hydrogen trailers resulting from advanced technology can be off-set by the distribution cost savings from increased truck capacity. This project will assess the effects that can be achieved by the introduction of high capacity trailers composed of composite tanks with respect to weight, safety, energy efficiency and greenhouse gas emissions. Transport of compressed hydrogen today is strictly regulated by international and regional regulations. New materials and product capacities available today have the potential to increase the payload of a single trailer from about 350 kg hydrogen today to more than 1000 kg. Materialising this potential is therefore of great importance for the efficient distribution of hydrogen to refuelling stations with high throughput. This will require changes to existing Regulations, Codes and Standards (RCS) in particular for proof pressures higher than 65 MPa and tubes larger than 3000 litres. Adopting these changes is a time consuming process and will only happen if authorities are convinced that the necessary safety precautions are taken care of to achieve a level of safety at least as high as observed with today’s distribution technologies for hydrogen. The proposed project will address these challenges by means of a detailed assessment of safety, environmental and techno-economic impacts of the use of higher capacity trailers and subsequently by the development of a preliminary action plan leading to a Roadmap for the required RCS amendments, which will be communicated to the authorities in charge.

Keywords: hydrogen transport,rcs,high capacity cgh2 trailer,composite cylinders,hydrogen distribution,hydrogen truck delivery,adr,enlargement of tranport capacity,bulk transport,high pressure
Solid Oxide Fuel Cell micro-CHP Field Trials (SOFT-PACT)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: United Kingdom,Germany,United Kingdom,Netherlands
Call:  (FCH-JU-2010-1, 2010)
Start date: 2011-07-08
End date: 2015-10-07
Duration (months): 51.0
Total project cost (EUR): 10312703.0
EU funding (EUR): 3950893.0
Participants: 4
Project status: CLOSED

A consortium has been formed to validate solid oxide fuel cell (SOFC) micro CHP technology in a real market environment. The consortium consists of a utility company, a heating system manufacturer, a fuel cell company and a software company specialising in microgeneration control systems and virtual power plants. The project consists of two phases: Phase 1: Deployment of forty BlueGen™ 2 kWe SOFC generators with domestic hot water cylinders or thermal stores (Pathfinder systems). Subject to location a boiler upgrade may also be included Phase 2: To design, build and deploy sixty 1-2 kWe SOFC micro-CHP units based on current prototype test systems (integrated systems with condensing boilers) The SOFC Technology chosen has a very high electrical efficiency (initially 60% LHV) and low thermal output which allows for 24/7 operation throughout the year. Deployment of units will be in occupied residential locations with a small number also being installed in test homes to provide reference data with the existing tests of prototype units and as a baseline for the field trial systems. The field trial demonstration will last for 36 months and provide the following outputs 1.Power generation export to the grid from fully integrated Fuel Cell systems and fleet management 2.Systems capable of being integrated into a future Smart Grid 3.Component optimisation and supply chain development; 4.Installation and field support workforce training and capability build; 5.Systems capable of integrating into existing power and heat infrastructures; 6.Validation of the system efficiency, cost and lifetimes compared against JTI targets; 7.Identification of barriers or risks hindering full commercialisation; 8.Feedback to the RD&D activities on required mitigations 9.Environmental sustainability via life cycle analysis; 10.Promotion of the project to a wider audience and prospective customer via website, vase studies and marketing material

Keywords: sofc,fuel cell,field trial demonstration,stationary,micro-chp,control,ict,standards,optimisation,installation,training
Modelling of Architectures Ruled by Coupled or Heightened Excited States (MARCHES)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physical and Analytical Chemical sciences
Countries involved: France
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

The goal of the MARCHES project is to rationalise and optimize the interplay between electronically excited-states in complex molecular architectures. The simulation of the properties of large conjugated architectures is to be performed with ab initio tools explicitly taking into account environmental effects. Though efficient methods able to tackle such task are to be conceived during this project, we aim to enlighten coupled excited-states so to pave the way towards chemically-intuitive designs of new molecules. Indeed, the rationalisation and optimisation of the excited-state properties of large compounds is not only one of the major challenges of computational chemistry and physics, it also opens new horizons for emergent properties. In that framework, this project will allow to design molecular switches usable as building blocks for complex logic gates, subsequently unlocking crucial steps towards more efficient storage materials. To this end, compounds containing several photochromic switches coupled at the excited state have to be designed: this is an important challenge. Indeed, photochromes are actually limited to uncoupled or simply additive systems: emergent multi-addressable features are impossible to achieve.

Keywords: electronically excited-states,density functional theory,solar-cells,photochromes
Phase transitions and computational complexity (PTCC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Computer science and informatics
Countries involved: Germany,United Kingdom
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-10-01
End date: 2016-09-30
Duration (months): 60.0
Total project cost (EUR): 1099575.48
EU funding (EUR): 1099575.48
Participants: 2
Project status: CLOSED

This is a project in the area of Theoretical Computer Science, particularly discrete algorithms and computational complexity. Many Constraint Satisfaction Problems (`CSPs') such as Boolean satisfiability or graph coloring are well-known to be NP-hard, i.e., the worst-case computation time to solve these problems is exponential in the size of the problem instance. To illuminate the conceptual origins of the computational hardness of these problems, a major research effort over the past 30 years has been the study of Random instances of CSPs. Over the past decade, motivated by problems in statistical mechanics, physicists have developed stunningly detailed hypotheses on the structural and conceptual nature of random CSPs, based on ingenious but highly non-rigorous techniques. These hypotheses have led to a new class of Message Passing Algorithms, as well as to evidence that certain natural types of random CSPs may be computationally intractable. The goal of this project is to study these ideas rigorously and comprehensively from the perspective of the theory of computing.

Keywords: theoretical computer science: discrete algorithms and computational complexity theory
TEchnology MONitoring and ASsessment (TEMONAS)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Coordination and support actions
Partnership: FCH (Art-185)
Countries involved: Germany,France,Austria,Switzerland,Poland,Portugal
Call:  (FCH-JU-2010-1, 2010)
Start date: 2011-09-01
End date: 2013-05-31
Duration (months): 21.0
Total project cost (EUR): 1800602.0
EU funding (EUR): 1132046.0
Participants: 7
Project status: CLOSED

TEMONAS is an advanced TEchnology MONitoring and ASsessment tool combining state-of-the-art methodology and IT-implementation. The objective of the TEMONAS is to provide an integrated TEMONAS tool specifically tailored for the needs of the FCH JU program progress evaluation. TEMONAS will take the many existing technology monitoring and assessment frameworks a step further in providing a transparent methodology allowing a targeted, objectivised comparison and evaluation of project results and technology achievements. This tool enables the continuous assessment of FCH JU progress versus its objectives and in respect to incumbent or competing new technology as well as current market and policy developments. The main functionalities of the tool are: • Data Input/Management • TMA Report outputs • Technology Assessment • Technology Monitoring The project will complete the methodologies for these functionalities and also perform their implementation in a comprehensive IT tool. Input data, stored in standardised formats and passing quality validation, will be used for benchmarking and multi-criteria evaluation as well as processed towards Technology and Commercial Readiness Levels (TRL-CRL). Finally the fully reproducible results are summarised in a partial automatically generated report, containing executive portfolios, as base for a fact based decision process of FCH JU.

Keywords: technology monitoring,benchmarking,multi criteria decisions aid tool,integrated management tool,database,fuel cell,hydrogen
Developmental neurotoxicity assessment of mixtures in children (DENAMIC)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Climate change, pollution, and risks
Action type: Collaborative project
Countries involved: Netherlands,Netherlands,Sweden,Spain,Slovakia,Norway,France,Romania,Czechia,United Kingdom,Germany,Croatia
Call:  (FP7-ENV-2011, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 9245375.25
EU funding (EUR): 6993863.4
Participants: 16
Project status: CLOSED

Various recent epidemiological studies have indicated that exposure to low doses of environmental biologically active contaminants during human development can alter gene expression and have deleterious effects on cognitive development in childhood. The DENAMIC project is ultimately focused on reducing such effects of environmental contamination on learning and developmental disorders in children. It aims to study and evaluate environment-health relationships in children. Key elements are: development of sophisticated tools and methods for early warning and screening of compounds for neurotoxicity, to study mechanisms of disease development and the role of individual susceptibility, to improve assessment of exposures and effects, focus on combined exposures to environmental agents that can interact to enhance adverse effects and reduction of health inequalities of children through Europe. One of the main aims of DENAMIC is to develop tools and methods for neurotoxic effects of mixtures of environmental pollutants at low levels, possibly resulting in (subclinical) effects on learning (cognitive skills) and developmental disorders in children (e.g ADHD, autism spectrum disorders and anxiety disorders). A broad suite of contaminants will be included in the studies, with options to bring in new chemicals in case evidence comes up during the project. With 14 partners from ten different countries DENAMIC has a true international character. It is a comprehensive, multi-disciplinary project. Six SME’s will play a key role in the development of biotechnological screening tools. The most modern techniques in the fields of genomics, proteomics, metabolomics and transcriptomics will be applied. Dissemination will ensure the project results to arrive at policymakers' desks, and will also illustrate the subject for a scientific audience and the public. The very large network of the consortium ensures dissemination to European industries, and every other interested stakeholder.

Keywords: developmental neurotoxicity,children's health,chemical exposure,adhd,cognitive disorders,risk assessment
Bioelectrochemical systems for metal recovery (BIOELECTROMET)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Environmental technologies
Action type: Collaborative project
Countries involved: Netherlands,Sweden,Finland,Netherlands,Spain,Luxembourg,United Kingdom
Call:  (FP7-ENV-2011-ECO-INNOVATION-TwoStage, 2011)
Start date: 2012-04-01
End date: 2016-03-31
Duration (months): 48.0
Total project cost (EUR): 4205504.07
EU funding (EUR): 3301743.0
Participants: 8
Project status: CLOSED

Global primary metal resources are rapidly dwindling and the mining and metallurgical industries are increasingly turning to lower grade minerals for metal extraction, typically increasing costs. Innovative environmental metal extraction techniques are required to increase mining sustainability, increase revenues and lower its impact on the environment. In this project, bioelectrochemical technology is proposed as an entirely new method for metal processing with the aim to produce marketable metal-containing (intermediate) products with low environmental impact compared to state-of-the art technologies. In bioelectrochemical technology, microorganisms catalyse the reaction occurring on one or both electrodes of an electrolytic cell. Such cells are called Microbial Fuel Cells (MFCs) when power is produced and Microbial Electrolysis Cells (MECs) when power is required to drive the desired reaction. Recently, it has been shown that Cu2+ is reduced to metallic copper on the cathode of a MFC coupled to the biological oxidation of organic matter and with resulting electricity generation. The proof-of-principle MFC almost completely recovered the Cu2+ in its metallic form (decrease in concentration from 1 g/L to < 1 mg/L) and produced a maximum power density of 0.8 W/m2. Bioelectrochemical technology can be used for the base metals copper, nickel, iron, zinc, cobalt and lead, which are mined, processed and used in large quantities. These metals are ubiquitous in process- and waste streams from the mining and metallurgical industry and therefore application of bioelectrochemistry for these metals has a high impact. Compared to traditional techniques, the use of Bioelectrochemical technology allows high recovery efficiencies, increased metal selectivity and reduced use of energy with in some cases (e.g. copper reduction) electricity production.

Keywords: metal recovery,copper,bioelectrochemical,water