Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative bioinspired strategies towards selective lanthanide complexation and separation: From bacterial chelators to applications. (LANTHANOPHOR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany,Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 1496935.0
EU funding (EUR): 833101.6
Participants: 2
Project status: SIGNED

Lanthanides (Ln) are critical raw materials and designated with a high supply risk by the European Commission. Their mining and purification have a considerable negative environmental impact and we urgently need sustainable and efficient recycling strategies for these elements. It was recently discovered that many bacteria use Ln for growth and utilize them in the active sites of enzymes. In addition, a Ln-binding protein with unprecedented affinities for Ln (Lanmodulin, LanM) has been isolated from one of these bacteria. The Ln-uptake mechanisms of these bacteria remain vastly underexplored, however, the involvement of polydentate ligands (chelators) to bind lanthanides — lanthanophores (lanthanide carriers) — has recently been established. For the first time, practical applications of chelators that were specifically designed by nature to bind, recycle and separate the technologically-indispensable lanthanides are in reach. Thus, the objective of LANTHANOPHOR is the identification and isolation of lanthanophores from the spent media of lanthanide-utilizing bacteria and the synthesis of short peptides based on the Ln-binding moiety in LanM. A comprehensive characterization of the lanthanophore including their lanthanide coordination chemistry, will contribute to our understanding how Ln are made bioavailable inside bacterial cells. The lanthanophore and the peptides will be evaluated for the use in Ln separation and recycling. I will further elucidate whether these ligands can be used in lanthanide bioremediation or for medical applications as chelators. The results of LANTHANOPHOR will advance the development of sustainable solutions and bioinspired applications that are urgently needed in the quest for new, environmentally friendly and faster Ln separation and recycling technologies. The unique combination of lanthanide biochemistry and coordination chemistry in my group opens unparalleled opportunities for discovery and characterisation of lanthanophores.

Keywords: lanthanides,siderophores,bacterial metabolism,bioinorganic chemistry
AI software for the automated detection of covid-19 infection on chest CT (CoronAI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-04-01
End date: 2021-06-30
Duration (months): 15.0
Total project cost (EUR): 2728750.0
EU funding (EUR): 1910125.0
Participants: 1
Project status: CLOSED

An AI platform to support medical practitioners to screen potential COVID-19 patients using medical imaging. Aidence is creating a new product to automatically analyse chest CT scans and diagnose the presence of corona (covid-19) viral infection. The product receives an image from the CT scanner, analyses it, and returns an easy-to-read report on the most likely diagnosis. This is done in the background fully automatically and the report is available for medical staff within a few minutes. Studies indicate CT is as least as sensitive as the current RT-PCR kit for testing, and is very fast. It is useful in case no kits are available, or when they are inconclusive, and/or radiology staff is unavailable or untrained. This product can be used for triaging as well as longer-term monitoring and early warning for future outbreaks. Because the solution will be operating on all CT chest scans and fully automated, once deployed in hospitals around Europe it will also serve as a case registry for management reporting and tracking of a new potential corona outbreak.

Keywords: corona,covid 19,deep learning,pandemic,diagnostics,radiology,lungs,respiratory system
Sexual selection in plants: testing new ideas on the perception of the mating environment and on the mate choice physiology (PERCEPSION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Sexual selection has been extensively studied in the animal kingdom but much less so in plants. Nevertheless, increasing evidences suggest that sexual selection has played an important role in shaping plant reproductive strategies. Besides the strong paucity of study on plant sexual selection, the field has mostly focused on male-male competition occurring during the phase of pollen dispersal. We are especially ignorant of whether plants have evolved the ability to filter mating partners based on their pollen grain characteristics during the post-pollination phase of the life-cycle, resembling a female choice. It is equally unknown whether plants have evolved some ability to perceive their reproductive opportunities and plastically adjust their vegetative and reproductive morphologies as to maximize their chances to access mates. The PERCEPSION project uses a multi-disciplinary approach combining experimental evolution, paternity analyses and physiological analyses to study aspects of plant perception and filtering of mating partners. PERCEPSION aims at (1) quantifying the variation between females in their style physiology during the post-pollination phase and relate it with the number of mates and with the performance of pollen grains of their partners; (2) evaluating through experimental evolution both the evolution of style morphology and physiology linked to their ability to filter pollen grains and the evolution of pollen grain performance in situations of monoandry vs. polyandry; (3) testing empirically whether plant-plant communication allows plants to perceive their mating opportunities and the genetic diversity of their mates and plastically adjust their reproductive strategy to maximize their chances to mate and (4) evaluating empirically whether mechanisms such as the production of airborne volative compounds or below-ground signals could be involved in plant-plant communication in relation to mate partner perception.

Keywords: sexual selection,plant reproductive strategies,experimental evolution,plant plant communication
Electrical Discharge Machining for enhanced osseointegration and antibacterial capabilities of β-phase Titanium Implant (EDiMplant)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-05
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Recently, the demand for orthopaedic implants and devices has undertaken rapid growth due to the aging population and its global market is anticipated to reach $66.2B in 2023. To ensure the long-term survival of orthopaedic implants, it is urgent to tailor a multifunctional surface which would simultaneously have enhanced osteogenic and antibacterial properties. Therefore, the aim is to develop a competent surface modification technique which will promote improved osseointegration whilst retaining antimicrobial activity, thus ensuring the life-long performance of implants. A novel surface modification approach will be demonstrated using the specially designed tool electrodes in powder mixed electric discharge machining process for fabrication of modified surface layers exhibiting anti-bacterial and osteogenic characteristics. Exploiting world class facilities at University of Sheffield and a unique multidisciplinary framework; EDiMplant will reach the aim and strengthen the pillars of Horizon 2020. Supervisor(s) with world-leading experience, Dr Gwendolen Reilly, Dr Frederik Claeyssens, Dr Russell Goodall, and Dr Joanna Shepherd, will provide expert training and support to the Fellow in the essential skills inmaterial science, tissue engineering and infection biology, while, Dr Deepak Unune, leading Indian researcher, will bring expertise and novel application of electric discharge machining in surface modifications of implants to the host(s). The high-quality two-way transfer of knowledge required for this project will ensure the research goals of the highest quality are achieved, whilst also presenting a great opportunity to accelerate the academic career of the Fellow. Success would also lead to significant economic and societal impacts for the EU and worldwide, by aiding in the reduced incidence of orthopaedic implant failures.

Keywords: electric discharge machining,anti bacteria,osseointegration,biomaterials
PAPTIC – The Good Conscience Alternative (PAPTIC)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Finland
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-11-01
End date: 2019-04-30
Duration (months): 30.0
Total project cost (EUR): 3136875.0
EU funding (EUR): 2195812.0
Participants: 1
Project status: CLOSED

Non-degradable, poorly recyclable, easily littered and long-lasting plastic products cause extensive accumulation of problems and endanger complete ecosystems. About 1 trillion plastic bags are used every year, with 89% of them only once. Despite the urgency of the problem, no viable alternative has been found up to now. Paptic addresses this global challenge and satisfies the needs of consumers, retailers and brand owners for sustainable carrier bags. The company has developed the novel wood fibre based material PAPTIC® that combines the renewability of paper with the resource efficiency and functionality of plastics. Once fully developed, PAPTIC bags will be 100% biodegradable and recyclable, with at least 85% renewable content. The patented PAPTIC® bags are the World’s first economically sound and environment-friendly alternative to plastics bags. Although market entry is achieved through carrier bags, PAPTIC® will revolutionise the whole flexible packaging market expected to be worth > €200 billion by 2018. The production logistics of Paptic is based on utilising existing paper mills, enabling rapid scale-up with low CAPEX investments. Paptic has already built a sales pipeline worth more than €150 million, representing some of the best-known brands and retailers in the World. With some of them, Paptic is conducting tests with extremely favourable feedback from brand owners, and has launched its first marketing campaigns. Also feedback from consumers has been thoroughly positive. The PAPTIC project is the next logical step in the company’s strategy. The focus is on scaling up production capacity from the already operational pilot line to a commercial prototype production line, and improving the performance of the PAPTIC@ material. As a result of the PAPTIC project, the company will grow to annual revenues of €90 million within a few years.

Keywords: sustainable carrier bags,feasible alternative to plastic bags,biodegradable,renewable and recyclable fibre material
Sea, Sand and People. An Environmental History of Coastal Dunes (DUNES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Portugal
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-11-01
End date: 2024-04-30
Duration (months): 66.0
Total project cost (EUR): 1062330.0
EU funding (EUR): 1062330.0
Participants: 1
Project status: SIGNED

Dunes are now protected environments, being top priority for coastal managers, because of their important role as coastal defences. But, it was not like that in the past. For centuries dunes were considered unproductive and dangerous. The sand blown by the wind was taken inland, invading fields, silting rivers and destroying villages. In the eighteenth century, a strategy was developed to fight against the dunes: trapping them with trees, with the double purpose of preventing the destruction of arable land and increasing their economic value converting them into forest areas. Different governments, in different countries supported the immobilization of the shifting sands. The strategy, developed in Europe, was taken to other places in the world. These works caused profound changes in vast coastal areas transforming arid landscapes of sandy dunes into green tree forests. This project aims to explore human-environment relations in coastal areas worldwide, since the eighteenth century until today, through the study of dunes as hybrid landscapes. Based on selected case-studies and comparative approaches, the project will focus on the origins, reasons and means of dunes afforestation; the impacts of the creation of new landscapes to local communities and ecosystems; and the present situation of dunes as coastal defences and rehabilitated environments. The final purpose is to produce an innovative global history of coastal dunes, combining knowledges from both Humanities and Social Sciences and Physical and Life Sciences, which has never been done. Supported by an interdisciplinary team, this research will result in new developments in the field of the Environmental History studies; provide relevant knowledge considering the need of efficient management solutions to adapt to the expected mean sea level rise; and stimulate environmental citizenship by disseminating the idea that the future of the world coasts depends on today’s actions.

Keywords: environmental history,coastal zones,governance,environmental citizenship
Innovative and highly-efficient solar thermal collector for Building façades (Prisma)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Sweden
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2017-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Heating and cooling in our buildings accounts for 40% of energy consumption and 36% of CO2 emissions in the EU. Moreover, 84% of heating and cooling is still generated from fossil fuels, while only 16% is generated from renewable energy. By improving the energy efficiency of buildings, we could reduce total EU energy consumption by 5-6% and lower CO2 emissions by about 5%. In 2016, the Commission proposed the EU Heating and Cooling Strategy that includes plans to make energy efficient renovations to buildings easier. The EU/Global market is requesting a cost effective and high efficient solution. Current commercial solutions are of very low efficiency, expensive and not suitable for old buildings. Asoluna, a Swedish SME that designs and manufactures solar energy solutions, has design and prototyped Prisma: a multifunctional solar thermal collector for integration in the building envelope in such forms as facades, decorative elements, parapets, glazing etc. It acts as a climate envelope that efficiently protects the building from unwanted heating or cooling, while at the same time delivering solar heating to the building’s systems. Crucially, it has been designed in collaboration with some of Europe’s leading sustainability architects to be easy to retrofit on to existing buildings. Prisma exhibits the following characteristics: 1) 100 % renewable energy; 2) Patented; 3) Reduces annual energy costs by 50 % throughout the building’s life; 4) High efficiency (<80%); 5) Suitable for new and old buildings; 6) Easy to install; 7) Follows the statutory instruments, directives and standards for façade applications; 8) Low environmental impact; 9) Cost effective; 10) Unique design with no frame; 11) Various colours and shading available; 12) Designed by architects, for architects. We anticipate that Prisma will be launched on to the market in 2020 and reaching sales of 28.5M€ by 2024, with a Net Present Value of 12M€ based on a project cost of SME phase II of 2M€%.

Keywords: renewable energy,solar thermal collector,highly efficient,building fa ades,low environmental impact,easy to install,energy cost reduction
Textual Microcosms: A New Approach in Translation Studies (TextualMicrocosms)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 1999655.0
EU funding (EUR): 1999655.0
Participants: 1
Project status: SIGNED

Interlinear translation – a bilingual genre that includes an original text and its word-for-word ‘equivalents’ in translation written in alternating lines on a single page – has been practiced in diverse societies over many centuries, yet has been little studied. Because it prioritizes detail and precision, the interlinear translation paradigm tells us more than any other about the workings of translation and the unavoidable choices inherent in every translation act. This project employs the interlinear text as a theoretical and methodological framework to study inter- and intra-cultural contacts, intersections and divergences. Approaching such texts as “textual microcosms,” it will explore a host of religious, intellectual, literary and linguistic processes and encounters as expressed and reflected on the interlinear page. The study’s focus is on interlinear translations produced between the late 16th and 20th centuries in the Indonesian-Malay world, a historically and culturally linked region now encompassing Indonesia, Malaysia, Brunei, Singapore, southern Thailand and the southern Philippines. One of the world’s most linguistically diverse regions, it has seen Hindu, Buddhist, Confucian, Christian, and Islamic textual traditions locally adopted and adapted over the centuries, often through the interlinear model. Five themes will be examined and combined in researching multiple texts to produce a holistic study of the interlinear phenomenon: local terminologies; religio-cultural aspects; script choice and use; standardization, untranslatability and mistranslation; visual elements. The study will expand our understanding of the nature of translation’s manifestations worldwide and offer new conceptual and methodological tools for studies of other regions and cultures. The findings will be of relevance to linguists studying language change, historians of culture and of religious pedagogy, and scholars in manuscript studies and art history.

Keywords: translation,indonesian malay world,islamic manuscript studies
Resolution Pharmacology and Physiology of MCTR in Arthritis (MCTRinIA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-03-01
End date: 2021-08-31
Duration (months): 66.0
Total project cost (EUR): 1964303.0
EU funding (EUR): 1964303.0
Participants: 1
Project status: CLOSED

Chronic inflammation may result from failure of the host response to engage pro-resolving pathways. The current treatment armamentarium for chronic inflammatory conditions may lead to immune suppression. Thus, identification of novel therapeutics that control inflammation without immune suppression will provide an attractive alternative approach. This is especially important since incidence of these conditions increases with an ageing global population. In planaria, mice, human peripheral blood and milk I recently uncovered a new family of endogenous molecules, named Maresin Conjugates in Tissue Regeneration (MCTR). These potently regulate white blood cell responses, promote the resolution of acute inflammation and accelerate tissue regeneration. The aim of this Starting Grant is to identify pathways that lead to failed resolution in inflammatory arthritis, as a prototypical chronic inflammatory condition. The hypothesis is that MCTR biosynthesis is dysregulated in inflammatory arthritis, leading to an unbridled host response, chronic inflammation and tissue destruction. This proposal will employ a multipronged approach to test this hypothesis by 1) Determining MCTR regulation in self-resolving and delayed-resolving arthritis; 2) Investigating the host protective and tissue regenerative actions of MCTRs in inflammatory arthritis; 3) Establishing the MCTR biosynthetic pathway and 4) Determining the regulation if its components during self-limited and delayed-resolving arthritis. Anticipated results will uncover novel pathways that become dysregulated during failed resolution. Results from this Starting Grant will also identify targets and new therapeutic approaches that will engage pro-resolution programs as well as tissue regeneration in conditions characterised by persistent inflammation and hence failed resolution. This will lay the basis for informed structure-activity based studies and the design of therapeutics for treatment of chronic inflammatory conditions.

Keywords: innate immunity and inflammation,chemical biology