Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Migration trajectories, natural experiments and effects of small-area contexts on health: a privacy-preserving linkage study of routine and primary data among resettlement refugees (INTERSECT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-07-01
End date: 2029-06-30
Duration (months): 60.0
Total project cost (EUR): 1999990.0
EU funding (EUR): 1999990.0
Participants: 3
Project status: SIGNED

The health effects of the migration trajectory, from pre- to post-migration in new environments, have yet been poorly studied. Methodological challenges and selection effects limit the possibilities for causal inferences on how differences in social, economic, or political factors at small-area level affect variation in health among migrants (e.g. differential mortality or self-reported health). Knowledge about such relations would not only inform better and health and integration policies for migrants. Considering migrants as humans in new environments (not as singularity), may allow to conclude on the relationship between context and health more general, and inform public health beyond immigration. However, randomisation of individuals into new contexts is not possible, and establishment of prospective cohorts (from pre- to post-migration settings) is challenging, resource-intensive and prone to selection bias. The aim of INTERSECT is to study human mobility and health consequences of different social, economic and policy environments at small-area level. To this end, INTERSECT builds on three innovations: i) it re-constructs the migration trajectory by using existing data among German-bound re-settlement refugees through data-linkage or distributed computation techniques, ii) it capitalises on mandatory dispersal as natural experiment to minimise selective migration into contexts, iii) it prospectively collects primary data on health of resettlement refugees and combines these with administrative and contextual data. Using these methodological innovations, INTERSECT creates a unique research infrastructure that allows answering important research questions on social, economic and political factors at small-area level which causally explain A) mortality differences among refugees while considering baseline health status; B) changes in self-reported health status depending on changes in contexts; and C) individual and/or contextual factors moderating such effects.

Keywords: social epidemiology migration trajectory natural experiments social policy small area contexts
Microbially Induced Mineralisation of Wood for Improved Fire Resistance (MICRO-INSERT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Slovenia
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 171399.36
EU funding (EUR): 171399.36
Participants: 2
Project status: SIGNED

Wood is the only renewable construction material and holds great promise for sustainable built environments of the future. However, its combustibility is a major limitation. The drawback of using traditional fire and flame retardants is the toxicity and volatility of some of their components and the loss of chemicals by leaching, leading to poorer performance. Mineralisation of wood offers a green alternative, but current strategies often require a costly technical setup for supercritical gases or the use of harmful chemicals to achieve the deposition of minerals deep inside the wood structure. Biologically induced mineralisation is a widespread phenomenon occurring in all kingdoms of life. In recent years, microbially induced calcium carbonate (CaCO3) precipitation has been proposed as a potential solution to address many environmental and engineering issues related to the enhancement of inorganic materials (protection of concrete, soil consolidation). However, the potential for using fungi has received relatively little attention compared to bacteria. The MICRO-INSERT project will investigate the feasibility of using fungi as CaCO3 carriers to develop a novel bioinspired mineralisation process for biobased building materials. Wood as a highly porous, three-dimensional organic scaffold will be mineralised to create hierarchically structured organic-inorganic hybrid materials with novel properties, including improved fire resistance. The proposed bioinspired treatment incorporates ideas for sustainable materials design, circularity, reduction of toxicity, and lowering the negative impact on the environment. The MICRO-INSERT project will stimulate innovation and knowledge transfer between the host and ER by building a solid research network, organising events, mentoring young researchers, and managing projects. The ER will gain research and scientific skills and acquire a new set of competencies to reach professional maturity and independence after the fellowship.
Multilevel inflammatory regulation in cardiometabolic disease (MIRACLE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,Finland,Germany,Italy,Belgium,Sweden,United States,Switzerland,France
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-02-01
End date: 2028-01-31
Duration (months): 48.0
Total project cost (EUR): 2839314.14
EU funding (EUR): 2728126.6
Participants: 18
Project status: SIGNED

The benefit of targeting inflammatory pathways in cardiometabolic disease on top of traditional healthcare and medication is evident from recent clinical studies. However, generalized blocking of inflammation also impacts on patients’ defense against infections and other immune-associated pathologies, such as cancer. Clearly, more precise interventions that target disease-specific cellular subsets and mechanisms are eagerly awaited. MIRACLE’s focus on innovation is to pave the way to precision medicine by deploying and valorizing current technological breakthroughs for a detailed definition and targeting of cardiometabolic disease-associated and causative cellular subsets. MIRACLE is inspired by latest advances in single cell biology, multi-omics analysis and newest insights in macrophage biology. These advances revealed heterogeneous and dynamic accumulation of (immune) cell populations in tissues that associate with disease initiation, development and particularly clinical outcome, a notion that has immense implications on our view of chronic inflammatory diseases and their treatment. Unique know-how is ready to be transferred to highly talented fellows. In MIRACLE, twelve young scientists will receive tailored training that enables them to study local and environmental factors that drive cardiometabolic inflammation as well as develop strategies to suppress them, via the integrated use of cutting-edge single cell, spatial mapping, computational and disease modeling approaches. Moreover, they will be able to develop and polish skills in translational science by working with biotech- and pharma experts and clinicians pledging clinically actionable outcomes. The combination of high-level science with top-notch infrastructures, resources, and solid data places MIRACLE at the forefront to move single cell biology towards cardiometabolic (precision) medicine and foster the scientists of tomorrow.

Keywords: cardiometabolic disease,single cell biology,multi omics analysis,disease modeling
nordiC hydrOgen eNergy VallEY (CONVEY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Norway,Denmark,Finland
Call: Small-scale Hydrogen Valley (HORIZON-JTI-CLEANH2-2023-1, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 21984542.5
EU funding (EUR): 8999998.51
Participants: 11
Project status: SIGNED

The overall objective of the Nordic hydrogen energy valley (CONVEY) project is to establish and demonstrate a hydrogen closed-loop ecosystem in the Hirtshals Port (HP), Northern Denmark, by deploying an innovative, economically viable and renewable energy system (RES) infrastructure. Annually, 550 tons of green hydrogen will be produced via using the renewable electricity (32,160MWh / year) generated by the windmills located in the industrial area of the port. Efficient downstream management of both hydrogen and electrolysis’ by-products, i.e. excess heat, oxygen, will be enabled by an integrated and synergetic sector coupling, involving the greater value chain of the port. The CONVEY valley mainly constitutes of i) the renewable (wind) energy production site at the Hirtshals port site, that powers ii) a 4MW hydrogen production facility, also located at HP’s premises, iii) the pipeline infrastructure for fast and climate-friendly H2, heat and O2 distribution (retrofitting of existing gas grid and new builds) and iv) the initial three off-takers, comprising road transport logistics and food industry for both primary production through aquaculture (O2 and excess heat for marine nutrition production) and biorefinery for food ingredients (H2 for powering enzymatic hydrolysis process technology). Overall, CONVEY will unlock unseen value for the Hirtshals region and beyond by 2050, i) economically: accumulated revenues of €23.86bn and €17.89bn for the H2 system and RES operators, respectively, as well as accumulated savings of €1.70bn, €471m, €877m and €640m respectively for the H2 transport off-takers, as well as food industry off-takers of H2, O2 and heat energy; ii) environmentally: accumulated overall savings (transport and food industry sectors) of 75.34 megatons (Mt) of CO2-equivalents (CO2-e) by displacing fossil fuel driven activities; iii) socially: 825 and 30,285 accumulated full-time and temporary jobs created for operating and installing the systems.

Keywords: renewable energy supply,hydrogen valley,heat and oxygen supply,circular business model,energy storage,hydrogen transport and distribution,pilot system operation,hydrogen valley replication
Innovative career development programme that enables 50 talented, international researchers to work on industrially focused sustainability research projects (Sustain-FIT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Ireland
Call: MSCA COFUND 2023 (HORIZON-MSCA-2023-COFUND-01, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 7164000.0
EU funding (EUR): 7164000.0
Participants: 1
Project status: SIGNED

Sustain-FIT is an innovative MSCA COFUND programme providing international mobility by funding and implementing 50 three-year incoming fellowships to the Republic of Ireland in the area of industrially focused sustainability research. Sustain-FIT will be run by Enterprise Ireland, the national innovation agency and the Fellows will have the option to be hosted at any of the Irish higher education institutions and public research organisations. The Sustain-FIT research and innovation focus is on the European Green Deal eight policy pillars: clean energy, sustainable industry, building and renovating, sustainable mobility, biodiversity, sustainable food systems, eliminating pollution and climate neutrality. Digitalisation projects that benefit Green Deal objectives are also supported, in line with the Declaration on a Green and Digital Transformation of the EU. Implementation of the programme includes an extensive promotion of recruitment calls to an open, merit-based competition for the applying researchers, founded on equality of opportunities and best practices in international peer review. Applicants will have the freedom to choose their Host Research Organisation (HRO) and Secondment Enterprise, and to define their own research training project. Recruited Fellows will be supported with a dedicated programme management arrangement that has access to the full range of Enterprise Ireland professional supports and HRO supports in a structured career development framework that includes a mandatory 6-12 month intersectoral secondment, high-quality supervisory support from the HROs and Enterprise Secondment partners, access to discipline-specific training and structured transferable skills training, and personal career development support. Sustain-FIT will develop a new cadre of researchers who can move seamlessly to industry in Europe bringing high levels of research expertise in an area of high priority: industrially focused sustainable research.

Keywords: industry,enterprise,sustainability,applied research
PHA-based iNnovative agriculTurAl Solutions to deliver bio-based ferTIlisers and plant protection produCts (PHAntastic)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Netherlands,Sweden,Belgium,Bulgaria,Austria
Call: Advanced (nano and bio-based) materials for sustainable agriculture (RIA) (HORIZON-CL4-2023-RESILIENCE-01-TWO-STAGE, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 7384272.5
EU funding (EUR): 7384272.5
Participants: 15
Project status: SIGNED

Agrochemicals (i.e., fertilizers and pesticides) are responsible for doubling crop yields over the last century. However, they cause multiple negative impacts on environmental and human health. To lessen their effects, the EU aims at reducing by 50% fertilizer losses and use of chemical pesticides by 2030. Controlled polymer-based delivery systems preventing agrochemical losses (e.g., lixiviation, volatilization) and resulting excessive inputs are available. However, they are based on non-biodegradable polymers and generate plastic pollution. Other agricultural plastics (mulch films and growth foams) are used to maintain a prosperous plant environment and prevent agrochemical wash-off, minimizing the quantities to be applied. However, they also result in significant amounts of non-biodegradable plastics being released into environment. PHAntastic tackles the reduction of agrochemicals and plastics pollution using PHAs, a family of bio-based biodegradable polymers. PHAntastic will develop two families of delivery systems (mulch films and growth foams) based on PHAs containing active bioproducts (amino acids & hydrolyzed proteins, microelements, elicitors and plant growth promoting rhizobacteria -PGPR) instead of synthetic agrochemicals. Products will be demonstrated with end users (TRL6) on horticultural crops and trees in Northern and Southern Europe. Experts in the Safe and Sustainable by Design framework will guarantee compliance. Market acceptance will be guaranteed through the development of business cases and exploitation strategies. PHAntastic will contribute to a significant reduction of agrochemicals (minimum 25% in fertilizers, 50% in pesticides, resulting in 23 K tons less of agrochemicals by 2050) and plastic (680 T microplastics less by 2050) in our agricultural systems. PHAntastic will thus contribute to a secure supply chain of food and a less impactful agriculture, boosting the sustainability, autonomy and competitiveness of vital EU value chains.

Keywords: agrochemicals,delivery systems,agricultural plastics,biopolymers,polyhydroxyalkanoates,phas,mulch film,foam,fertilizer,pesticide,circular economy
Investigation on the vaccination potential of IL4i1 deficient dendritic cells in Chronic lymphocytic leukemia (engineereD to Clear)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

Chronic lymphocytic leukemia is a common leukemia in adults characterized by an extremely immune suppressive microenvironment, which leads to the failure of otherwise effective immunotherapy regimens including dendritic cell (DC) based tumor vaccines. Recent attempts to understand immune suppression in CLL provided substantial evidence and identified that over-expression of amino acid catabolizing enzyme interleukin-4-induced 1 (IL4i1) in CLL and immune cells as key phenomenon in CLL mediated immune suppression. IL4i1 is secreted by DCs in the immune synapse and downregulates CD8+ T cell effector functions while presenting antigens, which perfectly explains failure of DC vaccines in CLL treatment. Addressing this, the important objectives of the present project are 1. To investigate the negative impacts of IL4i1 on DC functions, which are in particular relevance to DC vaccines and 2. To analyze the potential of IL4i1 deficient DCs in CLL vaccination. In this project I will first study ex vivo the DC and CD8+ T cell dysfunctions associated with DC secreted IL4i1 by assessing antigen presentation, immune synapse formation, CD8+ T cell activation and proliferation using both model antigen SIINFEKL and whole CLL cell antigens. Next, I will feed IL4i1 deficient DCs with whole CLL cell antigens and study using cutting-edge techniques their potential in eliciting anti-CLL immune responses in vivo using Eµ-TCL1 adaptively transferred CLL mouse model (TCL1AT). I obtained my PhD in 2021 and presently working as research associate at the department of Biochemistry and Molecular Biology, University of Szeged, Hungary. I propose this project for Marie Curie postdoctoral fellowship- European fellowships. This project will be carried out in the division of Molecular Genetics, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Heidelberg, Germany under the supervision of Dr. Martina Seiffert.

Keywords: chronic lymphocytic leukemia,immune suppression,il4i1,aryl hydrocarbon receptor ahr,dendritic cells,dc vaccines,anti tumoural immunity,cytotoxic t cells
A Smart and Adaptive Framework for Enhancing Trust in 6G Networks (SAFE-6G)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Greece,France,Romania,Spain,Cyprus,Finland
Call: Reliable Services and Smart Security (HORIZON-JU-SNS-2023, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 4325545.14
EU funding (EUR): 3998540.5
Participants: 14
Project status: SIGNED

The 6G vision for an open, distributed and user-centric evolution of the current SBA core network creates many security challenges and risks. The disaggregated heterogeneous cloud continuum (i.e. distributed cloud system with many stakeholders located in different regions, while private, public, or hybrid clouds are considered for the formation of the continuum), in conjunction with softwarization and IT-based infrastructure operations, set the stage for risks and challenges to trustworthiness in the 6G era. On top of the open and distributed 6G core over the edge-cloud continuum, SAFE-6G proposes a holistic research approach aimed to design, develop and validate a 6G-ready native trustworthiness framework by enabling user-centric safety, security, privacy, resilience, reliability functions. By utilizing (X)AI/ML techniques to cognitively coordinate and balance these functions, in order to optimize the Level of Trust (LoT), which realises the trust requirements and data governance policy that each user/tenant/human-role specifies, a feature that is considered an essential KVI for user-centric 6G. The proposed SAFE-6G framework covers the whole trustworthiness 6G lifecycle by applying trustworthiness analysis, realisation and post-evaluation during the whole user-centric service provision, from onboarding and deployment to operation and decomposition. Verification and validation of the proposed SAFE-6G framework will be performed at the Stream C SNS 6G-SANDBOX Athens platform using two Metaverse-based pilots. The immersive-applications will be tested considering different 6G system setups, different service flavors and deployments, under various threats and attacks.

Keywords: 6g trustworthiness,cognitive coordination,user centric,distributed,continuum,ai ml,xai,intent,security,privacy,safety,resilience,reliability,metaverse