Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Geo-analytical transformations for answering questions with data (GeoTrAnsQData)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1999500.0
EU funding (EUR): 1999500.0
Participants: 1
Project status: SIGNED

Geographic information systems (GIS) and corresponding data sources are of major importance for answering the questions posed by data scientists from various domains of application. The recent trend of adopting Artificial Intelligence (AI)-based methods in Geography and Geoscience has spurred hopes that geographic information can be successfully reused across disciplines without requiring the technical skills of GIS. In this context, geographic question-answering (GeoQA) methods are particularly promising because they enable users without a technical background to answer their questions about geographic space using natural language. However, most geographic questions data scientists may want to answer require some form of geo-analytical transformation of maps. Answer maps need to be (re)generated from data, rather than retrieved from storage. In contrast, stored maps are frequently lacking, outdated, biased, or of insufficient quality. For example, instead of retrieving statistical facts about noise intensity in a city, we might want to know about the coverage of noisy areas in this city. Yet, while the latter map might not be readily available, it could be generated from available sources. State-of-the-art factoid-based GeoQA methods are insufficient for this purpose because they directly match questions to facts, skipping over the problem of how unknown answers may be generated from these sources. In this project, we will develop an entirely novel paradigm for data-based question-answering, called transformative GeoQA, including a theory of geo-analytical transformations. The latter not only allows us to interpret questions in terms of the procedures for answering them but also to describe geodata as a source or purpose of a transformation. In GeoTrAnsQData, we lay the methodical and theoretical foundations for a groundbreaking data ecosystem that enables the quantification of geographic phenomena by generating maps using natural language.

Keywords: geographic question answering geoai geodata repositories geo analytical transformations gis workflows core concepts
Fully Printed Flexible Zinc-Ion Micro-Batteries (Flexi-Zinc) (Flexi-Zinc)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Developing on-chip planar micro-batteries with high-capacity, environmentally safe, cost-effective, and stable electrodes is essential for powering future miniaturized systems-on-chip smart devices. Planar-type device configurations, where electrodes are organized in an interdigitated electrodes (IDEs) pattern on the same substrate, provide several advantages over traditional sandwich types, such as controllable internal resistance and ionic diffusion distance, without a separator. These configurations reduce battery size and facilitate seamless integration with on-chip microelectronic devices. However, processing on-chip planar micro-batteries presents challenges, particularly in patterning metal IDEs current collectors using lithography techniques and loading active materials using traditional electrodeposition methods. These processes can hinder the direct printing of micro-batteries onto on-chip sensors, especially biomedical or related flexible sensors, making the realization of a systems-on-a-chip approach difficult. This project focuses on designing fully printed flexible on-chip planar zinc-ion micro-batteries (Planar-ZIMBs) using advanced Microplotter techniques. Printing the cathode and anode on metal-free exfoliated graphene current collectors eliminates complicated lithography and allows direct printing of Planar-ZIMBs with on-chip microelectronics. The innovation lies in exploring high-capacity manganese vanadium cathode and zinc anode materials without compromising material properties and integrating with a lithium-free compatible gel electrolyte, enabling micro-battery processing in environmentally friendly conditions and reducing overall processing costs. This new and innovative approach to developing micro-batteries is a critical advancement for the evolution of advanced miniaturized systems-on-chip smart devices.

Keywords: planar zinc ion micro battery,interdigitated microbattery,smart electronics,transition metal oxide cathode,flexible battery
Landslide and avalanchE Mechanics with Multiphysical datA (LEMMA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France,Switzerland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 3
Project status: CLOSED

Landslides and avalanches jointly cause approximately 150 deaths and €4.9 billion economic losses each year, with the impacts predicted to become more severe due to climate change. Mitigation and prevention of disasters requires accurate predictions of these phenomena, which due to their scale is only achievable via modelling and simulation. Accurate models of landslides in permafrost or avalanches must account for micro-scale (<1mm) processes such as cracks and shear bands that also involve thermal and hydrological effects that will be exacerbated by climate change. Such models do not currently exist. Further, this level of refinement is not computationally viable when modelling an entire mountainside, and so a new approach must be adopted. This project will: 1) Develop new models for permafrost and snow subject to climate-change-induced loadings; 2) Use the new data-driven mechanics framework to transfer information from these models to the scale of the mountainside; and 3) Simulate the effects of climate change on the Mont-Blanc massif at Chamonix. This will combine the researcher's experience with shear band models with the supervisor's expertise in crack models and optimisation techniques. A secondment at a group specialising in simulating landslides and avalanches will provide the expertise to implement the simulation on a real mountainside. This interdisciplinary project will ideally set the researcher for a career in academia in Europe, while benefiting the community at Chamonix, in particular the guide's association, as they will be able to plan adaptations and mitigations for the effects of climate change, ensuring their tourism industry remains viable. Specialised multiphysical models that are adapted to permafrost and snow will advance the state-of-the-art significantly, and the implementation of optimisation techniques in data-driven mechanics has wide applicability throughout civil and mechanical engineering, geology and environmental science.

Keywords: modelling,simulation,fracture mechanics,shear bands,thermo hydro mechanics,data driven,multiscale,material point method
Characterization of protective anti-pneumococcal B cell immunity after immunization. (IDSpnBmem)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: CLOSED

Pneumococcal pneumonia is one of the leading causes of death in children and the elderly worldwide. Pneumococcal vaccines have significantly reduced global incidence of pneumococcal disease, however, current vaccines show varying efficacy among covered serotypes, leading to insufficient level of protection for complete herd immunity. Memory B cells (Bmem) are responsible for high-affinity and long-lasting humeral immunity, and serotype-specific Bmem are associated with increased protection against pneumococcal colonization. Despite their critical role, to date, information on immunization-elicited cellular responses is limited. Here, I propose to characterize pneumococcal serotype-specific B cells for 25 cellular markers, transcriptome and BCR sequence, and link this phenotypic profile with functionality by analyzing recombinantly expressed antibodies. These analysis will involve the integration of 33-colour spectral flow cytometry, 10X next generation RNA and BCR sequencing, B cell cloning, generation of recombinant monoclonal antibodies and functional analysis by antibody avidity and opsonophagocytic capacity. Via computational science, using a data-driven and high-dimensional approach, I aim to identify the phenotypes of protective serotype-specific B cell immunity by analyzing individuals of different ages (children and adults), geographic location (Malawi and Europe) and immunization route (vaccination and colonization). This information will shed light on cellular differences of non-efficient vaccine responses, and may aid in development of improved vaccines. Additionally, the proposed activities and training by experts will be critical for my career development to become an independent researcher in the field of clinical immunology and vaccinology.

Keywords: memory b cells,serotype specific immunity,pneumococcal conjugate vaccines,cytometry,transcriptomics,bcr sequencing,b cell cloning,recombinant monoclonal antibodies
Circular RNA Therapeutics for Duchenne Muscular Dystrophy (circRNA4DMD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

RNA therapeutics is an emerging field explored in various types of diseases such as genetic disorders, cancer, inflammation and viral infections. Currently, most of the research focuses on the delivery of mRNA molecules that will transiently express a desired protein that can replace a defective protein or manipulate gene expression in the cells. My lab was the first to show systemic, cell-specific delivery of mRNA molecules in animals. Our approach and our novel amino lipids were translated to several clinical trials in the field of infectious and monogenic diseases. In protein replacement therapy, the main hurdle of using mRNA is the relative short half life of the mRNA. To address this, I suggest an approach for long-term expression: Circular RNA (circRNA), a covalently closed loop single stranded RNA that has a significant prolonged stability compared to linear mRNA. Thus, presents an immense advantage in protein replacement therapy. Duchenne muscular dystrophy (DMD) is caused by X-linked recessive mutation in dystrophin gene, leading to lack of functional dystrophin protein. This disease affects 1:5,000 males, causes a progressive loss of muscle tissues, ultimately leading to disability and premature death. Because DMD pathology is caused by the lack of functional dystrophin, restoring the function of dystrophin is a potential therapeutic strategy. As Lipid nanoparticles (LNPs) are the most clinically advanced candidate for RNA delivery, able to entrap large RNA payloads, herein I propose an innovative multidisciplinary approach for the specific delivery of circRNA-LNPs to muscle cells that will express the dystrophin protein and replace the defective one in a DMD mouse model. The long-term expression of the circRNA will offer new hope for the treatment of monogenetic diseases such as DMD. This approach may ultimately become a novel therapeutic modality for DMD and open new avenues for implementing circRNAs for other types of genetic disorders and vaccines

Keywords: lipid nanoparticles ionizible lipids rna therapeutics mrna circular rna duchenne muscular dystrophy
MILD Combustion with Nitrogen and Carbon Dioxide Reforming (MINICOR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Sweden,Italy,Denmark
Call: EIC Pathfinder Challenge: Carbon dioxide and Nitrogen management and valorisation (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 3697437.5
EU funding (EUR): 3697437.5
Participants: 4
Project status: SIGNED

Reduced net emissions of carbon dioxide (CO2) are necessary to achieve the goals of limited global warming and ensure a sustainable future for our society. This proposal presents a versatile and scalable process for management and valorization of CO2 and nitrogen. Starting from biomass residues, a first step in the proposed scheme involves a pyrolysis process that results in the release pyrolysis oil of rather low heating value. However, combustion under very diluted conditions using a Moderate or Intense Low-oxygen Dilution (MILD) concept allows for efficient and low-pollutant energy conversion. The MILD combustion process is utilized for a CO2 reforming step resulting in generation of syngas. The pyrolysis and the reforming are supplied by heat from the MILD combustion that can be further supplemented by intermittent energy sources such as solar and wind power. The residual char product from the pyrolysis step can be upgraded by activation with CO2 and utilized for adsorption of nitrogen from biomass. The nitrogen-enriched char can then be used for soil carbonization and nitrification. The concept thus addresses the objective of CO2 and nitrogen management with efficient renewable resource deployment. It also adopts a circular approach as it can employ biomass residues as raw material and combines the production of heat and syngas with that of porous biochar materials for several possible utilizations. The process can be adapted by multiple parameters and optimized for different conditions and purposes, and rather than optimizing on a single product or aspect, the concept brings a holistic view. The development of the process will include experimental research with state-of-the-art analysis methods, based on laser diagnostics and neutron scattering, combined with numerical modeling of the thermochemical processes. Life-cycle analysis will be made during the project to guide process development and assess its impact.
Biodiversity Meets Data (BMD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Innovation actions
Countries involved: Netherlands,United Kingdom,Belgium,Germany,Spain,Bulgaria,Estonia,Greece,Austria,Italy,Switzerland
Call: Digital for nature (HORIZON-CL6-2024-BIODIV-01, 2024)
Start date: 2025-03-01
End date: 2029-02-28
Duration (months): 48.0
Total project cost (EUR): 7358060.0
EU funding (EUR): 7265660.0
Participants: 14
Project status: SIGNED

Biodiversity Meets Data - BMD - is a Single Access Point that provides managers of natural resources and policy makers with access to high-throughput biodiversity monitoring tools and AI driven taxon identification services, services to mobilise historical baseline and legacy data to FAIR data repositories, a data catalogue to all available biodiversity information, a suite of Virtual Research Environments (VREs) for data analyses for the terrestrial, freshwater and marine realms, and a web-GIS data viewer to explore the data and VRE results. All data are harmonised across space-time-taxonomy and transformed into multi-dimensional data cubes that are analysed by the VREs. The VREs are co-designed with the stakeholder representatives to ensure that the VREs meet all requirements. The VREs include tools for a) biodiversity monitoring, b) identification and analysis of drivers of change, and c) projections of land cover and climate change on the distribution of species and habitats. The VRE results are presented as comprehensive products to the end users so that they can effectively be used to monitor biodiversity, address drivers of biodiversity loss, and plan, manage and expand protected areas, improve the conservation status of species and habitats, and comply to the reporting obligations under the EU nature directives based on up-to-date knowledge and solutions. BMD builds on a consortium of partners that are involved in the development of European research infrastructures and biodiversity monitoring projects, including eLTER (Integrated European Long-Term Ecosystem, critical zone and socio-ecological Research), LifeWatch ERIC, MAMBO (Modern Approaches to the Monitoring of BiOdiversity), BGE (Biodiversity Genomics Europe), B3 (Biodiversity Building Blocks for Policy, GBIF (Global Biodiversity Information Facility), and ARISE (Authoritative and Rapid Identification System for Essential biodiversity information) among others.

Keywords: co design,biodiversity data,data harmonisation,ai taxon identification,virtual research environment vre,fair workflow,climate change,land cover change,spatial planning,single access point
Engineering Water Repellent Coatings by Functional Nano-Sponges: a Springboard to Stable Perovskite Devices (SPIKE) (SPIKE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2023-01-01
End date: 2024-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The SPIKE project aims at realizing a revolutionary water repellent coating as a functional barrier to encapsulate photovoltaic (PV) electronic devices. Global solar encapsulation industry, massively pushed by the urgent increase in the solar energy demand, is expected to reach $11.37 billion by 2028 with a growing rate of 14.5% during the forecast period (2021 - 2028). Solar encapsulation is key to provide excellent durability to a PV module, an essential pre-requisite for its commercial viability. This is particularly true for the market exploitation of any new emerging solar technologies. Hybrid perovskite solar is an example: a key player in emerging PVs and a potential revolutionary system for smart PV integration in everyday life – being low-cost, coloured, and flexible. Their low durability, however, questions their marketable appeal. SPIKE aims to solve this issue demonstrating and bringing to the market an innovative technology based on smart nano-coatings which can revolutionize the solar encapsulation industry, and beyond. The coating is made of porous nano-sponges with tuneable functionality, transparency, flexibility, versatility and at reduced cost, overcoming the limits of the current commercial encapsulants (heavy, thick, costly, and involving high temperature processing). It is the goal of SPIKE to unleash the innovation potential of the proof of concept, by developing, technically validating, and bringing to the market such innovative technology, by: i) realizing low-cost, large area, robust coatings with a low energy consuming solution-based fabrication process; ii) integrating them in highly efficient perovskite solar modules; iii) demonstrating and validating a prototype in an industrially relevant environment; and iv) providing a reliable business model and market analysis to push our prototype to a commercial stage, building the bricks for the creation of a new start-up company, ultimate outcome of SPIKE.
FROM SINGLE MOLECULES TO CELL REPROGRAMMING: DECIPHERING AND RECODING DISORDERED PIONEER TRANSCRIPTION FACTORS (PIONEER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Iceland,Denmark
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: SIGNED

Pioneer transcription factors (pTFs) have unique capabilities beyond classical TFs: They can invade and open closed chromatin, initiating cell-fate changes. Their remarkable abilities have been used to steer cell-fate decisions and to induce a pluripotent stem cell state through poorly understood pathways. Like most TFs, pTFs consist of structured DNA-binding domains (DBDs) flanked by long intrinsically disordered regions (IDRs). In attempts to explain their pioneering functions, intense focus has been on how the structured DBDs of pTFs interact with the nucleosome core particle. Yet, the critical interactions with nucleosomes beyond the core particle, the interplay between DBDs and IDRs, and the molecular mechanism of chromatin invading and opening, remain unclear. The extensive disorder of pTFs places them outside the scope of current structural biology efforts and understanding their functions therefore requires a different approach. Single-molecule spectroscopy offers a powerful toolbox to monitor dynamic molecular systems and measure their conformational distributions. These methods enable quantitative modeling of distances and dynamics in biomolecules over timescales reaching over 15 orders of magnitude. Building on our recent breakthroughs in single-molecule techniques for studying highly disordered proteins in chromatin regulation and our preliminary data on pTF IDRs, we are in a unique position to apply our expertise to the molecular mechanism of pTFs. Using five established pTFs involved in four distinct cell reprogramming pathways, we intend to: 1) map conformational states, 2) decipher kinetic mechanisms, 3) engineer new pTFs, and 4) observe chromatin remodelling, both in vitro and within the complex cellular environment. A molecular-level understanding of pTF functions may break the barrier to fully controlling cell fate, unleashing the enormous medical potential of cell-based therapy.

Keywords: chromatin biophysics single molecule spectroscopy intrinsically disordered proteins pioneer transcription factors