Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Eco-Evolutionary Rescue of Fragmented Populations (EcoEvoRescue)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Norway
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Here I will establish eco-evolutionary rescue analyses as a predictive science. I will do this by developing theories, principles and tools for assessing whether populations can cope with changes in the environment at both short (ecological) and long (evolutionary) timescales. I contend that analyses involving the capacity of organisms to adapt to environmental changes must be based on theories including realistic ecological assumptions. My aim is therefore to develop a common theoretical framework for analyses of eco-evolutionary dynamics that includes basic features that characterize almost all natural populations, such as stochastic fluctuations in population size, density-dependent feedback mechanisms and dispersal among geographically separate populations. I will be able to achieve this ambitious goal because I have recently been involved in developing a new set of theories that have identified novel quantities based on general ecological characteristics that eco-evolutionary processes tend to maximize. These provide objective measures of a population’s capacity to change, which can be used to assess the consequences of habitat loss and changes in environment variation such as those expected due to climate change. I will be able to parameterize these models via my access to one of the largest individual-based long-term field studies of any vertebrate species including data of more than 36000 individual house sparrows from 18 populations on islands within a large geographical area of northern Norway, which will enable me to quantify processes rarely analysed before in natural populations. A central focus will be to derive new metrics that describe how the degree of persistence of a population to environmental change depends upon its size and population dynamic characteristics. Thus, this project will provide operationalization of eco-evolutionary rescue analyses as a research field for assessment of the vulnerability of species to global changes.

Keywords: quantitative genetics,conservation biology
Strengthening European Startups through interconnected and inclusive innovation ecosystems (INNOVATE-EU)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Germany,Romania,Spain,Latvia,Lithuania
Call: Startup Europe (HORIZON-EIE-2024-CONNECT-01, 2024)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 1459781.25
EU funding (EUR): 1459781.25
Participants: 8
Project status: SIGNED

The innovation ecosystem of the EU is suffering from a strong fragmentation with a big gap between innovation leader regions and emerging innovators. This divide severely limits the potential for innovative Start-ups from emerging and moderate innovator region to access capital and get adequate support for bringing their innovations to market. To tackle these challenges, INNOVATE-EU will strengthen and connect five local innovation ecosystems: the innovation leader region Baden-Württemberg (BW) in Germany, the moderate innovator regions of Lithuania and Aragon in Spain and the emerging innovator regions of Latvia and Northeast Romania. Its goal is to address the innovation gap between these regions, connect them to an EU-wide network of innovation ecosystems, and strengthen their deep tech Start-ups and Scale-ups by building on three (fundamental) pillars: i) a detailed analysis of the target groups and needs of the local innovation ecosystems followed by knowledge exchange and a detailed action plan to address the disparities, ii) the formation of the interconnected and inclusive INNOVATE-EU innovation support community and its connection to European communities, iii) direct support and trainings for promising deep tech Start-ups and Scale-ups providing them with the necessary knowledge, tools, and contacts for successfully upscaling their business models and bringing their products to market. Through this approach INNOVATE-EU will create an interconnected and inclusive innovation ecosystem with access to a wider European innovation support community and concrete pathways for existing and emerging deep tech entrepreneurs to access growth and investment opportunities. This will result in the overcoming of the innovation gap between moderately and highly innovative regions in Europe and the unveiling of disruptive and otherwise hidden Start-ups and Scale-ups in deep tech.
Depicting the extraction of cadmea and different mineral “earths” in ancient metallurgy (DE CADMEA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Cyprus,Germany
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 164328.0
EU funding (EUR): 164328.0
Participants: 3
Project status: CLOSED

Brass, a copper-ziBrass, a copper-zinc alloy, is a major alloy from Roman period and throughout the Middle Ages and early modern period. Despite its importance, relatively little systematic research has been done on its production, and archaeological evidence is less well documented than that for copper and iron smelting. One reason for this is the unassuming nature of most zinc ores and zinc-rich furnace remains, compared to the more easily identified copper or iron slags. DE CADMEA aims first to develop a systematic overview of zinc-rich materials, and related furnace remains from one of Europe's best-studied medieval mining and metallurgical regions, the Harz Mountains, before applying the experience gained onto another important mining region, Cyprus. Little is known about the exploitation of zinc in Cyprus, despite detailed and consistent references in key classical texts to the exploitation of 'earthy substances', described in a way that makes their identification as zinc/brass raw material highly likely, and several indications for zinc-rich smelting remains in the analytical literature. In collaboration with local archaeologists and geologists, the PF will systematically search for evidence for zinc-related metallurgy, broadening the current near-exclusive focus on copper metallurgy in Cyprus. DE CADMEA is an ambitious project producing an up-to-date review paper on historic brass raw materials and production technology, and potentially unravelling a totally new chapter in the metallurgy of Cyprus. The proposal also offers insight into the exploitation of non-standard earthy compounds that may be connected with other types of early metallurgy, such as the silver one. The fellowship is sided with two secondments: the Department of Mining Archaeology in Goslar, for the study of the mining district of Rammelsberg in Germany, and the Deutsches Bergbau-Museum Bochum (DBM) which will support the research with the archaeometric characterizations and interpretation.

Keywords: early metallurgy cyprus zinc,cementation metallurgy,raw materials
Fast and simple biomarker detection by computational microscopy (BioMarkerFlow)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-12-01
End date: 2026-05-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Detection of low concentrations of biomarkers, such as low-abundant proteins in physiological samples, is crucial for early-stage diagnosis and disease monitoring. However, existing detection methods are often laborious, costly, and time consuming, rendering them unsuitable for such applications. Based on advances in computational PSF engineering microscopy made during our ERC Starting Grant, and in combination with microfluidic design, we developed a simple and fast biomarker detection method which allows accurate and sensitive results with minimal hands-on sample processing, which we have validated for potential applicability in diagnostics, and specifically, for continuous monitoring. As a target clinical application towards which we can optimize our engineering efforts, we demonstrate the potential for preventative diagnostics via a collaboration with Rambam Medical Center (Israel), focusing on monitoring cell-based cancer treatments. While cell-based therapies can be highly effective, they have introduced new types of cytokine-related adverse effects that can be debilitating and even life threatening. Due to the current lack of appropriate diagnostics for preventative treatment, these adverse effects are mitigated only when symptoms arise, which might be too late. We hypothesize that earlier detection using our method will enable preventive treatment and reduction in frequency and severity of these adverse events, transforming patient outcome. We will develop a multiplexed cytokine detection scheme that reaches clinically significant sensitivity, and assess the effectiveness of this approach by monitoring CAR-T patients. In the duration of the project, we will conduct a market research and develop regulation strategy with the aid of industrial and medical collaborations, advancing our diagnostic method toward commercialization.
Tracing the origin of volatile elements in Earth and Mars using nucleosynthetic compositions of potassium and zinc in meteorites. (NuKleOrigin)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: SIGNED

The Solar System has long been thought to represent the only habitable planetary system. The discovery that planets orbiting Sun-like stars are common in our Galaxy has fostered the concept of planetary habitability, which defines the conditions at the surface of a planet required for life to develop, including the presence of volatiles, energy, and organic chemistry. Elucidating the relationship between the formation pathways of rocky planets and their potential habitability is crucial in that regard. One way to approach this is to determine the origin and composition of the building blocks of planets. Meteorites are witnesses of the earliest stages of planetary accretion and are ideal for this task. Nucleosynthetic anomalies (which are mass-independent variations of the isotope composition) measured in meteorites provide insights into the building blocks of planets. They are robust tracers because they are not affected by geodynamic and chemical differentiation of the planets. However, the determination of the building blocks of planets necessitates to consider a holistic approach considering constraints from elements with different volatility and cosmochemical behaviour in all extra-terrestrial materials. For instance, nucleosynthetic anomalies of refractory lithophile and siderophile elements do not provide precise constraints on the origin of volatile elements in planets. The very recent identification of nucleosynthetic anomalies in moderately volatile elements K and Zn opens new avenues of research as robust proxies of more volatile elements. This project aims at determining the source of the nucleosynthetic anomalies of moderately volatile elements and defining the building blocks of Earth and Mars building blocks and the source of volatile elements. I will use next generation instrumentation combined with emerging technologies to carry out this project.

Keywords: cosmochemistry,meteorites,nucleosynthetic anomalies,planet accretion
MISSION AGAINST A WIDESPREAD DISEASE: THE HEALTH APP AGAINST HYPERTENSION (Digital Health App)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 12.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The approach of Sanero Medical is to treat diseases through changing patients’ habits by informing and coaching them by means of health apps that feature Sanero Medical’s unique way of medical storytelling. Sanero Medical already is the provider of a leading quit smoking app and now targets further diseases and international markets. Sanero Medical’s unique and outstanding approach is to provide health apps, substantiating their effect by clinical studies and having them certified and approved as medical products, in combination with their unique medical storytelling. The market of digital apps as medical products on prescription by a doctor as it was introduced in Germany is of a new and challenging quality. In the meantime, the idea has been spread throughout Europe, other countries following and the European Health Initiatives already working on standards. Having introduced our first medical health app (DiGA = Digitale Gesundheitsanwendung / digital health app – as it is called in Germany) NichtraucherHelden (Non-Smoking Heroes), which currently is the only permanently approved smoking cessation app in Germany, we proved that we are able to handle the prerequisites and procedures to provide a medical health app and a good product, thus showing that we are at the leading edge of an evolving market. We want to be one of the first providers of health apps in other European countries that have similar conditions – a market of huge potential that is just about to start. To make sure we provide highly sophisticated medical apps, we focus on clinical studies and scientific research, collaborating with and employing scientific experts holding a doctor’s degree in Biology, Medicine, and similar disciplines so that our apps have an outstanding and proven effect. The current project and subject of the present application is a certified medical app for hypertensive patients, a widespread disease causing death and consequential illnesses.

Keywords: app on prescritption to increase health situation of hypertension patients app is designed to be certified as medical product clinical studies to be made to prove effectiveness
The role of developmental biases on the tempo of phenotypic evolution (EvoBias)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 172618.56
EU funding (EUR): 172618.56
Participants: 1
Project status: CLOSED

Understanding the mechanisms that generate phenotypic variation and their impact on the course of evolution is a central challenge in modern biology. The genetic architecture of development may limit or bias the phenotypic spectrum obtained after random mutation, deemed developmental bias. These phenotypic biases in turn may influence evolutionary trajectories. Despite the recognition of the importance of developmental biases in constraining and pacing evolution, there is no direct empirical evidence for this potential role. Here, I propose to tackle this key question using the ecologically-relevant avoidance to pathogens in the genetically-tractable organism Caenorhabditis elegans. To this aim, I will: (i) quantify and uncover mechanisms of developmental biases in avoidance behaviour; and (2) test the role of developmental biases on the tempo of phenotypic evolution. On the first objective, I will generate a novel panel of random mutant lines containing a transgene for whole-organism neuronal cell-fate identification, determine developmental biases in locomotor and avoidance behaviour, and uncover mechanisms of developmental biases. On the second objective, I will construct hybrid outbred populations with varying developmental biases to test their impact on the tempo of phenotypic evolution in an ecologically relevant scenario using experimental evolution. To achieve this, I will adopt an innovative interdisciplinary approach that combines my expertise in neurodevelopmental and behaviour genetics, quantitative genetics, genome-editing and know-how with the model C. elegans with that of the host lab in experimental evolution, behaviour ecology and host-pathogen interactions. Thus, promoting an active exchange of multidisciplinary expertise between the two parties. EvoBias will elucidate the role of developmental bias during the evolutionary process and its mechanisms in an ecologically-relevant scenario, and it will be a milestone towards my scientific independence

Keywords: developmental biases,mutational variance,experimental evolution,caenorhabditis elegans,evolution of behaviour,pathogen avoidance behaviour,host pathogen interactions
Irish Identities and Political Thought in Early Modern Historical Writing: Greek and Roman Sources (Irish identities)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

Current political debates relating to Brexit, the Northern Ireland Protocol, and the integration of the Republic of Ireland into the European Union, which reveal the pluralism of Irish identities including European, nationalist, and unionist visions, can be traced back to seventeenth-century reflections on conquest, state-formation, the Reformation, and colonial plantations in Ireland. This project investigates two foundational pieces of the seventeenth-century Irish historical writing: the Irish-language Foras Feasa ar Éirinn by Geoffrey Keating (1580-1644) and the Neo-Latin Cambrensis Eversus by John Lynch (1599-1677). Their narratives defended the history of Ireland from claims by the twelfth-century historian Giraldus Cambrensis about the ‘barbarous’ nature of the Irish people which were utilized by his early modern followers to justify the English conquest of Ireland in the sixteenth and seventeenth centuries. The project asks how and why early modern Irish authors exploited the cultural capital of classical rhetoric, history, and political thought through both Irish and Latin in order to fashion a distinct representation of Irish history, which underlined connections between Ireland and Britain as well as between Ireland and Europe. The results of the study will impact current understanding of the varieties of Irish national discourse as the Irish Republic reflects on a centenary of independence from Britain and on a fiftieth anniversary of its membership of the European Communities. The proposed research would be carried out at Aarhus University which excels in interdisciplinary research on European literature and culture, including Classical languages and culture and their reception in Ireland. AU university will enable me to update my expertise in early modern Irish and Neo-Latin languages and in Classical reception, which is necessary for the completion of this project.

Keywords: ireland irish identities early modern ireland celtic neo latin classical reception british monarchy
Deep mutational scanning of target protein resistance to molecular glues (DeepGlue)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Interactions between proteins and small molecules are rich in nature – across organisms, tissues and cellular contexts they underly crucial biological functions in health and disease. One class of small biochemicals, molecular glues (MGs), can selectively induce de novo protein-protein dimerization. Particularly in the context of targeted protein inhibition and degradation, MGs are praised as clinical alternatives to treating diseases driven by proteins that are otherwise pharmacologically intractable. Prominent examples like rapamycin, a MG used in the therapy of kidney tumours, illustrate a key research challenge, however: up until now, most MGs have been discovered by chance. Our limited understanding of their biophysical characteristics prevents us from rationally designing MGs, and from tracing drug resistance mechanisms by target proteins’ mutational escape during cancer evolution. Here, I propose a scalable experimental strategy to determine the binding profiles of MGs to thousands of target protein mutants in parallel. To perform comparisons of the biophysical impact of mutations on distinct MG mechanisms, I have three major aims: 1.) to develop a deep mutational scanning assay to quantify MG-protein-protein complexation, 2.) to produce the first global atlas of resistance mutations for a classic MG system – rapamycin in complex with MTOR and FKBP12, and 3.) to characterise ABA, a plant hormone which induces heterodimer formation by extensive structural remodelling of only one of its target proteins. “DeepGlue” will take place under the experienced supervision of Prof. Ben Lehner (CRG Barcelona), whose group has pioneered the use of deep mutagenesis to understand protein structures, dynamics and interactions. Within this environment, my action will be uniquely positioned to transcend the dynamic fields of Chemical Biology, Protein Biophysics and Cancer Evolution – aspiring to deliver fundamental insights that ultimately shape new and better therapies.

Keywords: deep mutational scanning,molecular glue,drug resistance,protein protein interactions,chemically induced proximity