Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Revealing the adaptive internal organization and dynamics of bacteria and mitochondria (Piko)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-10-01
End date: 2025-03-31
Duration (months): 66.0
Total project cost (EUR): 2366835.0
EU funding (EUR): 2366835.0
Participants: 1
Project status: SIGNED

Bacteria cells appear to be less complex than our own cells -- yet they are better able to survive harsh conditions. Typically ~1 micron in size, they lack motor proteins; thus, they rely on fluctuations for intracellular transport. Bacteria in the environment often face starvation and exist in a non-proliferating quiescent state, which promotes antibiotic resistance and virulence. Entering quiescence, the bacterial cytoplasm displays signatures of the colloidal glass transition, with increasingly slow and heterogeneous diffusion. Also important for fitness during starvation is the formation of storage granules up to hundreds of nanometers in size. The complex state behavior of the bacterial cytoplasm is therefore important for their survival, but the physical nature of each of these processes is poorly understood. Our own cells are typically tens of microns in size and contain organelles including mitochondria, which originated from ancient bacterial endosymbionts. But little is known about the transport properties of the mitochondrial matrix, or how it responds to changes in mitochondrial membrane potential or energy production. The goal of this project is to elucidate the organization and dynamics of the bacterial cytoplasm and the mitochondrial matrix. A major obstacle to studying the interior of bacteria and mitochondria is the relevant length scales, which lie below the diffraction limit. Furthermore, to observe and quantify their adaptive response, many cells must be measured. Our strategy to overcome both of these technical challenges is to use high-throughput super-resolution fluorescence microscopy. We have developed new microscopes, capable of capturing thousands of super-resolved cells in each experiment. We propose to translate these developments to dynamic structured illumination and long-term molecular tracking. Broadly applicable, this will also enable the quantitative study of the subcellular properties of single bacteria cells or mitochondria.
Mapping Uncertainties, Challenges and Future Opportunities of Emerging Markets: Informal Barriers, Business Environments and Future Trends in Eastern Europe, The Caucasus and Central Asia (MARKETS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Estonia,Germany,Ireland,Belgium,Finland,Georgia,Latvia,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-08-01
End date: 2025-04-30
Duration (months): 57.0
Total project cost (EUR): 3925791.36
EU funding (EUR): 3925791.36
Participants: 9
Project status: SIGNED

In the past ten years, diplomatic and economic relations between the EU and a number of post-USSR republics have steadily improved. Initially concerned primarily with internal political stability, countries like Azerbaijan, Kazakhstan or Uzbekistan have since come to realize that availability of oil, gas and minerals is not a guarantee for a stable and shock-resistant economic environment. Efforts to diversify domestic economies and to attract foreign investments have multiplied in the past years in the region, through initiates that include visa liberalization and economic and fiscal reforms aimed at reducing barriers to entry for foreign business seeking access to domestic markets. The response from the international business community to these efforts have been modest to date. While a number of corporate entities have tried to enter new markets, the attractiveness of such newly opened republics remain limited, in large part due to informal barriers to foreign investment. Such informal obstacles and hindrances remain largely under-reported and under-studied, contributing to a more general lack of understanding of local business environments that is exacerbated by a dearth of regional specialists who can understand and navigate the micro and macro socio-political economies of post-USSR markets. MARKETS responds to novel opportunities emerging in post-Soviet spaces by conducting a study on the influence of both formal and informal factors impacting on access to markets in eight countries in the post-USSR, including two countries per sub-region (Baltics, Eastern Europe, Caucasus and Central Asia) to 1) construct a map of business environments in the region based; 2) create, develop and improve the sustainability of training programmes for future analysts to equip them with deep practical understandings of the region, embedded in the newest theoretical and methodological approaches

Keywords: business environment,post soviet region,informality,caucasus,central asia
The first Hybrid Power Unit Retrofit Solution for airplanes (BLU-SPARK)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Spain,Italy,France
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2019)
Start date: 2020-04-01
End date: 2022-09-30
Duration (months): 30.0
Total project cost (EUR): 3973750.0
EU funding (EUR): 2781625.0
Participants: 5
Project status: CLOSED

BLU-SPARK aims at designing, developing and testing the first parallel hybrid airplane ever produced offering the pilot top dynamic performances, more flying safety and environment protection. The proposed hybrid airplane will represent a quantic step in the general aviation industry, bringing new benefits such as: more power with boost mode, increased climbing rate when necessary, back up propulsion in case of failure of the internal combustion engine, energy savings (ensuing strong reduction of overall greenhouse gas emissions); zero gas and noise emissions in airports; reduced dependence on fossil fuels; cost savings for the users, reduced worn out of mechanical parts. These advantages will be obtained at an affordable cost, neither spoiling the airplane dynamic performances, increasing the flying range. The key of this breakthrough is the new hybrid powertrain, integrating into one efficient and compact assembly a very innovative internal combustion engine, and an above the state-of-the-art electric system, made up of extremely compact electric motor and inverter, and battery pack. In addition the hybrid airplane features an innovating electronic structure that integrates in the AC-DC inverter the on board charger functionalities allowing to eliminate a very expensive and heavy component. In the past years some prototypes of full electric airplanes have been developed and shown to the technical community; in all the cases they are all linked to some common negative characteristics like very heavy battery pack and overall airplane excessive weight, very expensive price, extremely limited autonomy, missing the possibility to be accepted in the market in comparison to conventional powertrains. Therefore, no real market penetration has been reached Business model: 2 different way of reaching the market 1 Sales of the hybrid airplane and hybrid power unit directly to the final customers 2 Sales of the Hybrid power unit to airplanes manufacturers

Keywords: hybrid,airplane,power unit
Increasing the quality and rate of MultilayER packaging recycLINg waste (MERLIN)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Germany,Spain,Spain,Spain,Italy,Italy,Spain,Belgium,Croatia,France,France,Netherlands,Netherlands
Call: Improving the sorting, separation and recycling of composite and multi-layer materials (H2020-SC5-2020-2, 2020)
Start date: 2021-06-01
End date: 2024-05-31
Duration (months): 36.0
Total project cost (EUR): 4926225.0
EU funding (EUR): 4926225.0
Participants: 17
Project status: SIGNED

The high-performance requirements requested by the industry and consumers are responsible that currently 17% of total plastic packaging is multilayer material , meaning 3.03 Mt of plastics. Difficulties for recycling it are accentuated, being mostly landfilled or incinerated. MERLIN project has joined a partnership between sorting technology providers, recyclers, research centers, social innovation experts and end-users to design cradle to cradle solutions. This 36-month research project will offer innovative solutions for all the processes required to increase the quality and rate of recycled plastic materials coming from multi-layer packaging waste: (i) SORTING (combining optical sensors, Artificial Intelligence (A.I.) and robotics), (ii) DELAMINATION (optimizing depolymerisation and using solvent-based processes), (iii) RECYLING (techniques for repolymerization and upcycling of polymers) and (iv) VALIDATION (developing rigid and flexible packaging solutions and demonstrating circularity of the processes). These solutions will be developed and later validated in a real environment to reach technology readiness level (TRL) 6. This will be complemented with additional techniques and tools for circularity design to increase knowledge and effectiveness in the closure of the European multilayer plastic chain. Finally, transversal activities related to regulation and standardization, safety, sustainability, business, training, dissemination and communication will support to maximize the impact and effectiveness of the project. These actions are aligned with the ones proposed by the European Plastic Strategy to achieve that by 2030 all plastic packaging should be designed to be recyclable or reusable and decrease the quantity of waste generated Potential annual carbon footprint saving that could be achieved recycling all the multilayer waste in Europe could reach 7.42 Mt CO2/year, with a potential economic of €10,605 million and more 106,000 new job positions.

Keywords: multilayer packaging,chemical recycling,delamination,sorting
Origins of theory of mind: action prediction by great apes and human infants (MENTALIZINGORIGINS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Theory of mind (ToM) is the ability to impute unobservable mental states, such as desires and beliefs, to others. Our inferences about what others are thinking allow us to deceive and to empathize, to cooperate and to teach. For four decades, researchers have been attempting to elucidate the evolutionary and ontogenetic origins of this critical cognitive ability. In conflict with a long-held consensus, some have begun to argue that human infants (and to some extent great apes) share with human adults even the most cognitively sophisticated representational ToM abilities. To help resolve the intense resulting debate, this proposal presents a series of targeted experiments to test for several understudied but key ToM skills in great apes and human infants. The skills in question—attribution of (a) unfamiliar desires, (b) ignorance, and (c) false perceptions—form the basis of an organism’s ability to distinguish others’ minds from its own and build sequentially in terms of their cognitive and representational underpinnings. The present proposal marshals innovative new anticipatory looking eye-tracking methods and the most auspicious conditions available worldwide, through support of esteemed comparative and developmental psychologists Profs Josep Call and Malinda Carpenter and the School of Psychology and Neuroscience at the University of St Andrews, to address these major gaps in the social cognitive literature. The proposal’s novel anticipatory looking methods, which assess participants’ predictions based on their looks in anticipation of agents’ acting on specific locations or objects, combine low task demands (like VoE paradigms) with clearer interpretability (much like action-based tasks). The proposal thus offers powerful tests of the hypotheses that great apes and human infants share with human adults a representational theory of mind. These studies will contribute key data to our understanding of the ontogenetic and evolutionary precursors of the human mind.

Keywords: theory of mind,social cognition,mentalizing,perspective taking,great apes,chimpanzees,human infants,evolution,development,ontogeny
Personalised Postoperative Immunotherapy To Improving Cancer Outcome and improving quality of life (CANCER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Italy,Germany,Germany,Germany,Germany,Poland,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-03-01
End date: 2023-08-31
Duration (months): 66.0
Total project cost (EUR): 2430000.0
EU funding (EUR): 2430000.0
Participants: 19
Project status: SIGNED

During this RISE project we aim to develop nanoparticle-based encapsulated libraries of different immunotherapeutic biomolecules for treatment after surgery as part of a novel cancer management strategy. The current state-of-art for the management of cancer starts with surgery, after identification of an accessible tumour mass. Surgery remains an effective treatment option for many types of cancer today and it is considered curative treatment for most solid tumours. It forms part of a multidisciplinary approach used in conjunction with radiotherapy or chemotherapy. These approaches, however, have several limitations, including inability of surgical resection to affect distal metastatic disease, toxicity to healthy tissues with chemotherapy and lack of effectiveness of radiation therapy in more aggressive tumours. The observation that cancer can relapse months or years after initial surgery implies that micrometastases still resides within the body in a latent state. Our proposal is to take cancer therapy to beyond state-of-art by implementing techniques which will take us into new directions. This includes a) new methods to identify immune gene profiles and biomarkers b) transgenic mouse models where the complex interactions that underlie immune function can be visualised as multiplexed events in real time and c) the use of nanoparticle-based libraries of immune modulating reagent combinations. There are three key objectives within this project: i) to use immune gene signatures to monitor disease progression and therapeutic efficacy of immunotherapy combinations on nanoparticle-based platforms, ii) to optimise the platform to encapsulate libraries of immune components for more personalised, accurate and timely delivery of the payload to its intended target and iii) to optimise the overall cancer management process of image-guided surgery followed by postoperative immunotherapy so that we can ultimately provide a lifetime of protection against cancer.

Keywords: quality of life,less invasive approaches,immunotherapy
Assessment of Cross(X)-sectoral climate Impacts and pathways for Sustainable transformation (AXIS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: ERA-NET Cofund
Partnership: AXIS (ERA-NET)
Countries involved: Austria,Spain,Ireland,Germany,Moldova, Republic of,Norway,Belgium,Sweden,France,Netherlands
Call: ERA-NET on Climate Services Roadmap: Cross-sector impact assessments (evaluation, comparison and integration) (H2020-SC5-2017-OneStageB, 2017)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 15586070.0
EU funding (EUR): 5143403.1
Participants: 13
Project status: SIGNED

The AXIS consortium is set up to enhance integration of an array of research disciplines connected to climate research around the common goal to enhance the assessment of potential impacts of climate change on the bio-physical systems and human society. To this end AXIS plans to launch and implement a single transnational call – funded by 11 European research funders. Through an open process AXIS has developed three topics for this call. Each topic is intended to enhance collaboration across typical community borders: between different sectoral views of climate impacts as well as between bio-physical climate impacts and socio-economic effects. For all topics stakeholder engagement is given a high relevance in the call, thus representing another dimension of interaction across boundaries: interaction of the science community with end-users (stakeholders) of the created knowledge (transdisciplinarity). The three anticipated research areas (topics) are: (1) Cross-sectoral and cross-scale climate change impact assessments; (2) Integration of biophysical climate change impacts estimates with economic models; (3) Developing pathways to achieve the long-term objectives of the Paris Agreement, taking into account interactions with SDGs closely linked to SDG 13 (“climate action”). The AXIS consortium is deeply embedded in JPI Climate and aims to implement elements of its Strategic Research & Innovation Agenda. JPI Climate and the ERA-NET promoting Climate Services ERA4CS include a number of additional activities. Therefore within this proposal no addition activities are planned. Close partnership of the AXIS consortium and JPI Climate with other key international initiatives (Belmont Forum, GFCS, Future Earth, UN PROVIA, Copernicus) will be sought in order to continue to work against fragmentation of disciplines and geographies in climate science. In this respect a close connection with the parallel CSA proposal SINCERE is planned.

Keywords: climate service,climate change impacts,impact models,integrated assessment model,economics of climate change,vulnerability,impacts and adaption,mitigation,adaptation
Unification Through Law: The Court of Justice of the European Union as Cultural-Moral Agent (UNITE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2022-08-13
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

The Court of Justice of the European Union (‘CJEU’) has strongly contributed to the European Union (’EU’) as we know it today, through enlarging the competence base of the EU through its case-law. However, the current challenges that the EU polity faces, ranging from consecutive waves of enlargement, financial bail-outs, and waves of immigration, suggests that the EU may not need integration anymore, but unification. It may require an EU citizenry that is united in solidarity and willing to organize itself collectively, through forms of self-government. In the existing EU constitutional scholarship, judges are assumed to be able contribute to a unified citizenry by two major means. One the one side of the debate stand those conceptualization courts as ‘legal-interpretative’ agents that can strengthen forms of self-government if they interpret the law on the basis of distinct hermeneutical theories of legal interpretation representing the will of the citizens. On the other side of debate stand those conceptualization courts as ‘political-constitutional’ agents that can speak with the voice of the citizenry if they fulfill certain institutional conditions that allow citizens to participate in court decision. UNITE aims to explore new means through which the CJEU could, through its case-law, contribute to the unification of the EU citizenry and flourishing forms of EU self-government through conceptualization it as ‘cultural-moral’ agent. More specifically, UNITE is grounded in the assumption that the judicial opinion is a cultural artifact, which can, through the cultural narrative it is grounded on, give expression to and alter how citizens think about themselves and the community they inhabit. The project aims to reveal the shape and form of such cultural narratives through suggesting the use of political philosophy as analytical tool.

Keywords: court of justice of the european union,eu constitutional law,self government,qualitative methodologies
Novel smart glyco-nanomaterials as targeted therapeutics. (Glyco-Platforms)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-12-01
End date: 2019-11-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Cell surface carbohydrates play key roles in cell recognition mechanisms. Protein-carbohydrate interactions typically exhibit high specificity and weak affinities toward their carbohydrate ligand. This low affinity is compensated in nature by the architecture of the protein, the host presenting the carbohydrate ligands in a multivalent manner or as clusters on the cell or mucosal surface. O-glycosylation is a ubiquitous post-translational modification that is highly dynamic and responsive to cellular stimuli through the action of the cycling enzymes. Expression of specific O-glycans is linked to changes in gene expression in, for example, inflammatory bowel disease, cystic fibrosis and several types of cancer. Understanding these glycosylation patterns at molecular and functional levels will allow mechanisms associated with bacterial-host interactions, bowel disease and other cancers to be defined, which will facilitate the development of new effective therapeutics and diagnostic tools for these conditions. The proposal centers on the chemo-enzymatic synthesis of novel multivalent mucin-type O-glycan probes for the screening of O-glycosylation-linked interactions in health and in disease and the development of smart glyco-nanoparticles as drug delivery systems. This is a multidisciplinary project involving synthetic organic and inorganic chemistry and glycobiology.

Keywords: oligosaccharide synthesis,nanoparticles,bioimaging,cytotoxicity,cell biology,drug delivery