Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ultra Frequency-Stable Laser via Spectral Hole Burning in Rare-earth Ion Doped Crystals (UltraStabLaserViaSHB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: CLOSED

The UltraStabLaserViaSHB project seeks to catch the currently elusive grand prize of time and frequency metrology: a frequency source with a relative stability on the order of 10^-18 at 1 s. The desirability of this goal is borne of the near-future redefinition of the SI unit of time, the second. As optical atomic clocks surpass microwave-frequency atomic clocks in accuracy, the switch to an optical definition of the second drives the metrology field to strive to the fundamental performance limit of optical clocks, the quantum projection noise limit. Currently, optical clock performance is limited by frequency fluctuations of the optical-cavity-stabilized laser field which probes the atoms' optical transition. The optical lattice clocks located at SYRTE could reach their quantum projection limit if a probe laser with a sufficient frequency stability could be realized. The project proposed here seeks develop an ultra frequency stable laser at SYRTE to reach this performance via a paradigm shift in laser stabilization, away from optical cavity frequency references (which themselves approach their fundamental limit, Brownian noise) and toward a novel method: laser stabilization via spectroscopy of rare-earth ion doped crystals. This is achieved through a technique called Spectral Hole Burning (SHB) where a spectral pattern is imprinted on the crystal at cryogenic temperatures by a pre-stabilized laser (a spectral "hole" is "burnt"). A probe beam then interacts with this spectral hole and the resulting de-phasing of the probe beam provides the source for a control signal which allows us to actuate the probe laser, stabilizing it to the narrow line of the rare earth ion. Early results in this young technique are extremely promising and its limits are yet undiscovered. The result will impact not only time metrology, but all fields which rely on ultra-stabilized lasers such as gravitational-wave detection, fundamental constant measurements, and tests of general relativity.

Keywords: laser frequency stabilization,spectral hole burning,frequency metrology,time metrology,spectroscopy
Europe’s Rail Flagship Project 1 - MObility managemenT multImodal envirOnment aNd digitAl enabLers (FP1 - MOTIONAL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Europe's Rail
Action type: Innovation actions
Partnership: EU-RAIL (JU-JTI)
Countries involved: Germany,Netherlands,Portugal,Spain,France,Italy,Norway,Hungary,Austria,Poland,Sweden,Czechia,Luxembourg
Call: Network management planning and control & Mobility Management in a multimodal environment and Digital Enablers (HORIZON-ER-JU-2022-01, 2022)
Start date: 2022-12-01
End date: 2026-09-30
Duration (months): 46.0
Total project cost (EUR): 51362491.81
EU funding (EUR): 37875973.46
Participants: 96
Project status: SIGNED

“MOTIONAL” will enable the improved planning and operational management of services and offers and is therefore of paramount importance to meet the European ambitious target to make rail the preferred mode of transport in the future. It will enable the future European railway system to be interoperable, resilient, able to adapt capacity and able to integrate all involved services including last mile operations, exploiting the opportunities provided by digitalization. The “MOTIONAL” developments for the future European Traffic Management are key to achieve the foreseen Single European Rail Area. Today, rail traffic is managed on national/regional level supported by legacy systems with a poor level of digitalization and weak integration with systems of other actors participating in the overall traffic planning and management process. Through the development of functional requirements, associated specifications and operational or technological solutions and by taking advantage of the potential of digitalization, “MOTIONAL” will pave the way towards the implementation of the future European Rail Traffic Management System to make rail the backbone of a multimodal transport system for passengers and freight. The planned activities to achieve the objectives of Destination 1 are carried out in two major workstreams. Workstream 1 has the three major focus areas, Planning and Operation activities (dealing with the future interactively linked timetable planning and operational traffic management systems) and Integration activities (dealing with railway services to offer door-to-door mobility). Workstream 2 will deliver a set of digital enablers for all Europe’s Rail Destinations (i.e.“transversal”) to support the development of destination-specific digitalization solutions as Digitalization is a fundamental transformational process encompassing the Rail System as a whole.
Multi-site application of Open Science in the creAtion of healthy environments Involving local Communities (MOSAIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: Research and Innovation actions
Countries involved: France,Brazil,United States,Colombia,Kenya,Portugal,Poland
Call: Planetary health: understanding the links between environmental degradation and health impacts (HORIZON-HLTH-2023-ENVHLTH-02, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 5993603.75
EU funding (EUR): 5993603.75
Participants: 15
Project status: SIGNED

Planetary health requires a better understanding of the reciprocal negative effects and co-benefits between environmental changes, degradations and human health. This holds at all levels. Local communities of low- and medium-income countries, living in cross-border zones, face both the negative effects of environmental changes and degradations, impacting their health and well being, and particular socio-political contexts that enhance their vulnerability. MOSAIC states that these populations can be best suited to interpret and exploit complex and multi-thematic information about their surroundings, in order to identify and understand the impacts of the environment on their wellbeing and to develop locally feasible, acceptable, and sustainable adaptation and mitigation solutions. However, usually, access to information is weak and local communities do not necessarily have the required scientific literacy skills to fully benefit from it. MOSAIC aims to design and implement open, multimodal and replicable information ecosystems intended to support cross-border communities to i) understand the impacts of the environment on their well-being, ii) build a health-promoting environment, iii) influence public debate, public policies and public decisions. It relies on the Open Science principles, making: i) participatory and data sciences work together, with multiple disciplines and stakeholders, ii) scientists and society co-produce and make use of data and knowledge, with shared values. It will consider two bio-regions particularly affected by climate change, extreme climatic events, and land cover degradation, East Africa and the Amazon, with three cross-border study areas as “laboratory sites”. These study sites allow for implementation and evaluation of project developments, the testing of the reproducibility and reusability of methods, data and tools, and the facilitation of inter- and transdisciplinarity through the joint mobilisation of a multidisciplinary team.

Keywords: open science,participatory approaches,data science,climate extreme events,environmental degradation,east africa,amazon,cross border health,planetary health,one health
LIGHTING THE WAY TOWARDS IN SITU OSTEOCHONDRAL REGENERATION THROUGH MICROEXTRUSION AND FILAMENTED LIGHT BIOPRINTING (LUMINATE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Italy,Netherlands,Germany,Belgium,Croatia,Spain,Estonia,Switzerland,France
Call: Bio-printing of living cells for regenerative medicine (HORIZON-HLTH-2024-TOOL-11, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 7459148.75
EU funding (EUR): 7459148.75
Participants: 15
Project status: SIGNED

Traumatic injuries to the osteochondral tissues of diarthrodial joints like the knee result in pain, functional impairment, and increased risk of developing post-traumatic osteoarthritis (PTOA) and its comorbidities. Current treatments, based on cell-free grafts or cell-based therapies, are expensive and often with limited availability, ultimately leading to total arthroplasty to relieve the pain and restore function. However, the risk of revision of these implants is unacceptably high in young active patients, predicting a looming epidemic of revision surgeries as these implants start to fail. LUMINATE proposes a personalized, one-stage regenerative approach to target large osteochondral lesions, thus preventing PTOA and avoiding costly and invasive arthroplasty surgeries. LUMINATE will develop a next level in situ bioprinting unit, called EndoFLight, which combines three toolheads (i.e., micro-extrusion, filamented light, jetting) to print photoresins laden with patient-derived cells directly at the site of injury. EndoFLight uses filamented light to bioprint highly architected scaffolds with excellent cell guidance properties in seconds. Together with micro-extrusion and jetting toolheads in an arthroscopic set-up, we can deposit multiple biomaterials, biomolecules and cell types together with light-assisted crosslinking of complex structures directly in vivo in a minimally invasive manner. The whole procedure will be extensively validated in a human-relevant in vivo large animal model, paving the way for clinical translation after the end of the project. The exploitation of the results will be ensured through market analysis, the foundation of a spin-off that will commercialize the project results, and analysis of regulatory aspects of all components of the bioprinting suite. Overall, LUMINATE will ensure wide-spread health benefits to the patients suffering from these lesions and will pave the way for enormous socioeconomic advantages for our aging society.

Keywords: in situ bioprinting photopolymerizable bioresin osteochondral defect gmp procedure autologous chondrocytes and mesenchymal stromal cells arthroscopy medical device and atmp regulation
​Targeting Palmitic Acid Signaling Machinery to Inhibit Metastatic Cancer (PalmitoMet)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-12-01
End date: 2025-05-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Despite recent breakthroughs in immunotherapy and cancer research, metastasis continues to be responsible for 90% of cancer related deaths. While surgical resection and adjuvant therapy can cure localized tumors, once tumor cells metastasize, cancer remains largely incurable. Increasing evidence indicates that lipids play a crucial role in the metastatic process by providing energy and membrane components required for cell migration and outgrowth, and also by triggering specific signaling cascades that prime cancer cells into a metastatic program (Martin-Perez et al., Cell Metabolism 2022). Importantly, we have found that palmitic acid, but not other fatty acids, promotes metastasis in a large number of tumors, and that metastatic initiating cells require a lipid metabolism reprogramming driven by an epigenetic remodeling (Pascual et al. Nature 2017; Pascual et al. Nature 2021). We have solid evidence that fatty acids not only promote metastasis by providing energy to metastatic cells (Delauney et al. Nature 2022), but also by specifically modulating protein lipidation. Thus, targeting this particular lipid signaling machinery may represent an unexplored solution to combat metastasis. PalmitoMET aims to identify novel molecules capable of inhibiting specific protein lipidation to treat metastasis in preclinical models, with the aim to bring them closer to the clinic. Inhibitors found during this project have the potential to become first-in-class drugs, making this project a high risk but high gain project, considering the very large and growing market we are addressing
Mercury in the solar wind: adaptive kinetic model for space weather at solar system's innermost planet (MEOW)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Finland
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1997101.0
EU funding (EUR): 1997101.0
Participants: 1
Project status: SIGNED

We develop a new type of a global plasma simulation model with adaptive charged particle kinetic physics for the Mercury-solar wind interaction. Mercury’s solar wind interaction, or space weather, is unique in the solar system due to spatially small and temporally fast magnetospheric scales, airless solid body with a large conducting core, a tenuous surface-originating exosphere and the closest distance to the Sun of the planets. These features mean that Mercury is an ideal "compact-sized magnetospheric solar wind interaction laboratory" for spacecraft and model studies compared to Earth's much larger magnetosphere. Since Mercury's plasma environment is populated by a unique composition of exospheric heavy ions mixed with the solar wind, the magnetosphere is much smaller than at Earth and under stronger solar wind conditions, studying Mercury reveals new information on space weather processes in general. The main scientific objectives of the BepiColombo (BC) two-orbiter mission en-route to Mercury include the investigation of the structure and dynamics of the Hermean magnetosphere and exosphere. The new model to be developed in this project is based on high-performance computing and an adaptive algorithm for charged particle kinetic effects. This enables efficiently resolving Hermean space weather processes and the coupled, complex solar wind-magnetosphere-exosphere system at detail beyond current global models. The new model is applied in the interpretation of observations by BC with the focus on the role of charged particle effects in the physics of basic space weather processes.

Keywords: mercury,solar wind,exosphere,magnetosphere
PLATform for the Implementation of the Navigation Action programme for Action (PLATINA4Action)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Coordination and support actions
Countries involved: Netherlands,Austria,Hungary,Belgium,Germany
Call: Towards the implementation of the inland navigation action programme with a focus on Green and Connected Inland Waterway Transport (HORIZON-CL5-2023-D5-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 1550800.81
EU funding (EUR): 1499666.88
Participants: 7
Project status: SIGNED

Platform for the Implementation for green and connected Inland Waterway Transport IWT) as envisaged in the Action Plan of NAIADES III. The platform will act as catalyst, bringing together expertise, stakeholders and research in the field of European Inland Waterway Transport, building on the network and expertise developed in the CSA project PLATINA 3 funded under Horizon 2020. The PLATINA4Action project aims to accelerate the implementation of green and connected inland waterway transport. Activities will focus on 1) supporting and coordinating research and innovation activities focussing on green and connected IWT to find synergies between parallel developments, 2) impact estimations of NAIADES III actions and supporting the policy discussions to achieve modal shift and zero-emission IWT and 3) the updating of the Strategic Research and Innovation Agenda for IWT. The consortium will work closely together with European Commission DG MOVE in view of the NAIADES Implementation Expert Group and DINA Expert Group. Furthermore the consortium will involve and interact with IWT and logistic representatives and platforms, river commissions, ports and waterway managers, Member States and research institutes.

Keywords: iwt,zero emission,digital,smart,connected,innovation,stakeholder,policy,digital twin,roll out
An innovative therapeutic treatment to stimulate cardiac regeneration through lipid nanoparticles-mediated miRNAs administration: from design to correlative morpho-functional characterization (CardioReGen)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

During acute myocardial infarction (MI), up to 25% cardiomyocytes (CMs) in the left ventricle can die, which plays a major role in the progression to heart failure (HF). This loss is not compensated by new CM generation as, in adulthood, CMs lose their capability to proliferate. Recently, the host laboratory has proved that cardiac regeneration after MI can be stimulated by the therapeutic administration of various miRNAs in both mice (Eulalio et al., Nature, 2013) and pigs (Gabisonia et al., Nature, 2019). However, these studies also highlighted the safety issues related to the use of adeno-associated viruses for gene delivery. Here, we want to design a novel therapeutic treatment to regenerate infarcted hearts based on the administration of selected pro-proliferative miRNAs delivered through lipid nanoparticles, which have been recently approved clinically for other conditions and offer an unprecedented translational possibility to stimulate cardiac regeneration. The effects of treatment will be comprehensively characterized, both functionally and structurally, at both cellular and organ levels, using a novel reporter mouse in which replicating cells become genetically labelled. We will monitor cardiac function and analyze the number of replicating CMs, as well as angiogenesis and molecular and cellular parameters related to HF. By taking advantage of my expertise, we will perform whole-organ, high-resolution 3D reconstructions of the regenerated hearts, employing cutting-edge optical imaging platforms (Olianti et al., PBMB, 2021). The spatial distribution and arrangement of proliferating CMs, connexins and fibrotic patches will be mapped and quantified in 3D. For each heart, structural information will be correlated to functional analyses. The findings of this project will provide novel and important information on the molecular, functional and structural correlates of cardiac regeneration, which is essential to support therapeutic development in this field.

Keywords: cardiac gene therapy,myocardial infarction,mirnas,cardiac regeneration,optical imaging for whole heart 3d reconstructions
Development of Engineered Geopolymer Composites Bricks from Seawater and Construction Waste (SWCW-EGCBricks)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-16
End date: 2027-09-15
Duration (months): 24.0
Total project cost (EUR): 216240.0
EU funding (EUR): 216240.0
Participants: 1
Project status: SIGNED

The SWCW-EGCBricks project focuses on developing lightweight, high-strength engineered geopolymer composites (EGCs) bricks using seawater and construction and demolition waste (CDW). The use of geopolymers and upcycled concrete waste will address sustainability challenges by reducing environmental impact while maintaining high material performance. The project will introduce seawater to replace fresh water during manufacturing, reducing costs and promoting the use of renewable resources in the building industry. Following the pyramid principle of emerging composite material design, the project will be achieved through three key objectives: (1) determine the formulation of geopolymer, using a systematic approach to optimize the performance of the geopolymer when it is working with concrete waste and seawater; (2) establish a multi-scale model based on experimental microstructural and mechanical analysis to predict the performance of EGCs with varying fiber content, focusing on strength, toughness, and weight reduction; and (3) conduct manufacturing trails for EGC bricks, with durability and mechanical investigation, along with footprint calculation. To ensure accurate results, a combination of laboratory-scale trials and multiscale modeling techniques will be applied. Advanced microstructural characterization techniques such as SEM, XRD, and 3D microtomography will be employed to analyze the interaction between fibers and the geopolymer matrix. The project will also develop a predictive model that links fiber content to mechanical properties, guiding the optimization process for a high-performance, eco-friendly product. In addition to experimental work, the project will include a comprehensive environmental assessment, evaluating the carbon footprint of the materials developed. This will ensure that the new bricks align with the objectives of reducing greenhouse gas emissions and promoting circular construction practices.

Keywords: sustainable building material,composites,geopolymer,construction waste upcycling,micro structure analysis,multi scale model