Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Bifurcations in Several Complex Variables (BIF-SCV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2021-01-28
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This fellowship builds on the success of the applicant’s PhD thesis, where he made breakthroughs in the area of holomorphic dynamics in several complex variables. The field of holomorphic dynamics in several complex variables is a fast-growing area of mathematics, linking complex geometry, dynamical systems and many other topics. This project addresses the central question of studying stability and bifurcations of such dynamical systems under perturbation. The applicant’s foundational work has prepared the ground for significant advances in the subject, forming the basis for this project. This project specifically aims at the extension of parabolic implosion techniques (field in which the supervisor is a world-leading expert) from their natural one dimensional setting to higher dimensions (the applicant’s area of expertise). This proposal has three main directions. 1 - Establish the equivalence of various possible definitions of dynamical stability in this setting, and study in depth the many differences between the one and the several complex variables setting. 2 - Extend the theory to the case of systems of saddle type, i.e., generically displaying a repelling and an attracting direction. This case contains the Henon maps (polynomial diffeomorphisms of C^2), as well as explains the local dynamics near attracting sets for endomorphisms of P^2 (C). 3 - As part of the above points, contribute to a general theory of parabolic implosion in higher dimension.

Keywords: holomorphic dynamics,julia set,fatou set,bifurcations,parabolic implosion
Mobility Innovations for a New Dawn in Sustainable (European) Transport Systems (MIND-SETS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Israel,Spain,Italy,Belgium,Romania,Belgium,Netherlands,United Kingdom
Call: User behaviour and mobility patterns in the context of major societal trends (H2020-MG-2014_SingleStage_A, 2014)
Start date: 2014-12-01
End date: 2017-05-31
Duration (months): 30.0
Total project cost (EUR): 1755558.75
EU funding (EUR): 1755558.75
Participants: 8
Project status: CLOSED

The Mind-sets project (MS) will make a major contribution to our understanding of mobility in Europe: • How to better understand mobility (to better influence and change it) • How to predict the likely future attitudes to, and patterns of, mobility • What forms of mobility policies, products and services will best meet these future mobility needs The project provides a new approach to understanding mobility as part of the overall changing lifestyles of different population groups across Europe. A multi-disciplinary coordination of intelligence provides a strong platform for the reinterpretation of our understanding of the ‘mobility mind-sets’ of Europeans; based on engagement with other leading experts in the field in Europe. The approach will be validated against key behavioural issues facing mobility decision-makers: increasing automation, door to door seamless smart mobility, sustainable and energy efficient fuels and mobility and social inclusion. This enhanced understanding is developed into decision support guidelines (to be called ‘Mind-sets’) with a ‘Think Tank’ of practising mobility stakeholders (decision-makers, operators, developers and mobility system suppliers) to fine tune the guidelines to directly meet market needs. In turn, this will support decisions, create innovation future mobility policy and assist the design and marketing of new products and services. The project is strongly supported by an active exploitation and dissemination strategy, based on a ‘Mind-Sets Knowledge Centre’. Mind-Sets applies a new approach that brings mainstream sociologists, environmental psychologists, health and lifestyle specialists and economists together with sustainable mobility and travel behaviour specialists, plus experts in social media , technological and ITC trend analysis: a, new type of team, to assess mobility issues. Through successful exploitation, the project will also change the ‘Professional mind-sets’ of mobility decision-makers in Europe.

Keywords: mobility mind sets,future trends,decision making strategy,new knowledge,mobility patterns
Selection to outsmart the germs: The evolution of disease recognition and social cognition (DiseaseRecognition)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-01
End date: 2019-01-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

An astounding example of human social complexity is the global healthcare industry, in which we perform lifesaving surgeries, eradicate childhood diseases, provide global vaccinations, and track the evolution and outbreak of novel zoonotic diseases. Surprisingly, all of this hinges on a cognitive ability whose evolutionary origins are largely unknown: the ability to recognize disease in others. Under the mentorship of Dr Joanna Setchell (Durham University), a world-leading expert in primate disease signalling, Dr Sharon Kessler (fellow) will test her novel hypothesis that disease recognition evolved in associate with social cognition the primate order before the divergence of the human lineage. This multidisciplinary project integrates anthropology, psychology, and parasitology to test 1) whether a nonhuman primate signals infection status using visual, acoustic, and olfactory cues, 2) whether primates use these cues to recognize disease in others, and 3) whether disease recognition correlates with accepted measures of primate social cognition. The objectives will be achieved by taking photos, recording vocalisations, and collecting odour samples from semi-free ranging mandrills, Mandrillus sphinx, at the Centre International de Recherches Médicales mandrill colony in Gabon before and after treatment with anti-parasite medications. The photos, vocalisations, and odour samples will be presented to captive mandrills at the Colchester Zoo in the UK to test whether they spend different amounts of time investigating stimuli from parasitised and nonparasitised individuals. Performances on these disease recognition tests will be compared with performances in social cognition on the state-of-the-art Primate Cognition Test Battery. This innovative, multidisciplinary study increases the international networks of the participants, provides Kessler with cutting edge training, and breaks new ground on the role of disease in the evolution of primate, including human, cognition.

Keywords: primatology,social cognition,disease transmission
Online Monitoring: Electrochemiluminescence based Gated Assay (OMEGA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: SIGNED

To find new and better ways to detect and monitor contamination of water, food and the environment as early as possible directly at the site of impact is one of the most pressing tasks for researchers today. Early detection of and strategic monitoring to trace contamination of water is therefore crucial. This emphasizes the need for sensitive, robust, portable and affordable (especially for low-income countries) analysis tools that can report directly at site on the concentration of a target contaminant. Detecting contamination early means that these small, mobile analytical devices have to indicate analytes at very low concentrations with reliable uncertainty and accuracy, to avoid false positives and foster acceptance of such tools by relevant user groups like public employees. In this project, I will address this need relying on the integration of microfluidics, gated delivery systems, magnetic beads and electrochemiluminescence (ECL) detection. ECL is a detection method that operates against a zero background and gated delivery systems exhibit inherent features of signal amplification. A combination of both strategies with the versatile handling and miniaturization capabilities of magnetic beads and microfluidics promises to yield user-friendly, affordable and robust analytical devices with unprecedented performance for the reliable quantification of analytes at ultra-trace levels (ppb and below) directly onsite at the point-of-need. By matching my expertise in electrochemistry and microfluidics with the host’s expertise in gated delivery systems, magnetic beads, luminescence spectroscopy and device integration, I have the unique opportunity to receive training in various other disciplines, including metrology, that allow me to broaden my field of knowledge and to better shape the outline of my future career as a high-level (bio)analytical scientist.

Keywords: sensor,gated indicator release system,water monitoring,biomolecular recognition,electrochemiluminescent assay
Understanding HIV-specific B cell function and viral immunogenicity (HIV B Cell Function)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-06-01
End date: 2024-05-31
Duration (months): 72.0
Total project cost (EUR): 1499269.0
EU funding (EUR): 1499269.0
Participants: 1
Project status: SIGNED

I will establish how abnormal B cell behaviour contributes to the generation of HIV neutralising antibodies by studying B cell biology: Previous studies show that broadly neutralising HIV antibodies are the most highly-mutated human antibodies ever isolated, with unusually long binding loops and polyreactivity, suggestive of changes to B cell tolerance and germinal centre selection mechanisms. These remarkable antibodies develop only during HIV infection, concurrent with immune dysfunction, not following vaccination. Crucially, the cellular processes whereby these antibodies arise need to be elucidated and I hypothesize that doing so using RNAseq, flow cytometry and imaging B cell activation will answer why only a minority of HIV+ individuals develop neutralization breadth. Moreover, B cell dysfunction is associated to a range of malignancies and autoimmune diseases and, while much has been learnt from model antigens in mouse models, HIV infection provides a uniquely well-characterised human model to study B cell regulation. Another fundamental question is whether strain-specific antibodies are a stepping-stone to breadth, or a detour that must be eliminated in vaccination. I have shown that the best serum neutralization activity induced via stabilized HIV envelope protein immunization predominantly targets a strain-specific glycan hole, similar to many early responses observed in infection before broad neutralising activity develops. Therefore, I will determine whether non-neutralising and strain-specific antibodies affect the development of breadth by isolating a range of antibodies raised during viral infection from individual donors and comparing binding affinities, clonal ontogenies and B cell receptor activation. Defining the impact of competition between antibody specificities during HIV infection will be directly translatable to developing vaccines for other pathogens where cross-reactivity is a key factor such as Influenza, Dengue and Zika viruses.

Keywords: antibody,b cell,neutralization
The Unity of the Bodily Self (SELF-UNITY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Sweden
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 2583560.0
EU funding (EUR): 2583560.0
Participants: 1
Project status: SIGNED

How do we come to experience ourselves as single physical entities? Under normal healthy conditions, we humans always experience a single body as our own physical self, and this bodily self is undivided and perceived as a single whole. But what cognitive processes and brain mechanisms mediate this unity of the bodily self? This fundamental question has long been beyond the reach of experimental studies because of the lack of behavioral paradigms that allow controlled manipulation of basic components of the self-unity. To address this issue, we here propose the use of novel full-body illusion paradigms to “fragment”, “duplicate” or “split” the sense of bodily self during well-controlled behavioral and neuroimaging experiments. By studying the behavioral and neural principles that determine specific illusory changes in perceived self-unity, we can elucidate much about the neurocognitive mechanisms that support the sense of having a single unitary bodily self under normal conditions. Our pioneering behavioral paradigms utilize the newest virtual reality technologies, and these are combined with multimodal neuroimaging using the most advanced analysis methods, such as multivariate pattern recognition. The aims of the project are to unravel (i) how we come to experience a single bodily self as opposed to multiple ones; (ii) how we perceive a coherent bodily self instead of fragmented parts; and (iii) how information from different sensory modalities – including vestibular and interoceptive signals – are integrated to achieve this coherent sense of a singular bodily self. The new basic knowledge generated by this project will be important for future clinical neuroscience research into major psychiatric and neurological disorders with disturbances in self-unity, such as schizophrenia, dissociative disorders and stroke with body neglect, by providing novel ideas for hypotheses about the involved neurocognitive pathophysiology.

Keywords: perceptual illusions,body ownership,self consciousness,functional magnetic resonance imaging,virtual reality,cerebral cortex
Modelling and Orchestrating heterogeneous Resources and Polymorphic applications for Holistic Execution and adaptation of Models In the Cloud (MORPHEMIC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Italy,Greece,Switzerland,Greece,Greece,Poland,Poland,Norway,France,France,United Kingdom
Call: Cloud Computing (H2020-ICT-2019-2, 2019)
Start date: 2020-01-01
End date: 2023-06-30
Duration (months): 42.0
Total project cost (EUR): 4988693.75
EU funding (EUR): 4988693.75
Participants: 12
Project status: SIGNED

MORPHEMIC proposes a unique way of adapting and optimizing Cloud computing applications by introducing the novel concepts of polymorph architecture and proactive adaptation. The former is when a component can run in different technical forms, i.e. in a Virtual Machine (VM), in a container, as a big data job, or as serverless components, etc. The technical form of deployment is chosen during the optimization process to fulfil the user’s requirements and needs. The quality of the deployment is measured by a user defined and application specific utility. Depending on the application’s requirements and its current workload, its components could be deployed in various forms in different environments to maximize the utility of the application deployment and the satisfaction of the user. Proactive adaptation is not only based on the current execution context and conditions but aims to forecast future resource needs and possible deployment configurations. This ensures that adaptation can be done effectively and seamlessly for the users of the application. The MORPHEMIC deployment platform will therefore be very beneficial for heterogeneous deployment in distributed environments combining various Cloud levels including Cloud data centres, edge Clouds, 5G base stations, and fog devices. Advanced forecasting methods, including the ES-Hybrid method recently winning the M4 forecasting competition, will be used to achieve the most accurate predictions. The outcome of the project will be implemented in the form of the complete solution, starting from modelling, through profiling, optimization, runtime reconfiguration and monitoring. Then the MORPHEMIC implementation will be integrated as a pre-processor for the existing MELODIC platform extending its deployment and adaptation capabilities beyond the multi-cloud and cross-cloud to the edge, 5G, and fog. This approach allows for a path to early demonstrations and commercial exploitation of the project results.
A quorum sensing mechanism regulating CD4 T cell proliferation (CD4CRISPR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

The fine and complex regulation of CD4 immune response is important in cancer, autoimmune diseases, inflammatory disorders and viral infection. If signals orchestrating productive CD4 T-cell responses are well documented, the contraction of antigen (Ag)-specific CD4 T-cell populations following the resolution of primary immune response is however not molecularly understood. It has been demonstrated that a negative feedback loop can regulate CD4 T cell proliferation through direct T-T interactions, leading to the preferential exclusion of Ag-experienced T cells. This T cell intrinsic mechanism limits the expansion of effector CD4 T cells and may then interfere with therapeutic vaccine efficacy. Using Cas9-(constitutive/inducible)-expressing Dby-reactive T cells (from a TCR Transgenic RAG-/- mouse strain named Marilyn) coupled to a sgRNA library and an in vivo selection strategy, we will extensively identify the negative regulators of CD4 T cells migration and priming in an ongoing primary immune response. As a proof of concept, we will first inactivate candidate genes (already known to be involved in CD4 T cells negative regulation: TGF-b receptor,IFN-γ receptor, PD-1 and PD-L1) in Ag-experienced memory CD4 T cells, which will be enriched for their proliferative capacity in vivo and used as a second cohort in immunized mice. Then, we will develop a genome-wide screen approach to generate a library of knockout Ag-experienced T cells as a second cohort. We expect that further insight into CD4 suppressive mechanisms, which dampen efficient antitumor immune responses, will allow optimization of cancer immunotherapy.

Keywords: cd4 t cells proliferation,inhibition,crispr,genome wide screen
Propellant-Free Continuous-Dispensing Packaging Solution: From Commercial Pilot to Full Commercialization (Eco-Drive 2 Market)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-04-01
End date: 2021-12-31
Duration (months): 33.0
Total project cost (EUR): 1966875.0
EU funding (EUR): 1376812.0
Participants: 1
Project status: CLOSED

Aerosol dispensers have serious drawbacks, stemming from the presence of pressurized and, in most cases, combustible gas. The use of pressurized gas requires pressurized packages that must be rigid and cylindrical. The gas, metal and chemicals used are harmful to human health and to the environment, they come with inherent safety issues and they incur high manufacturing, transportation and handling costs. Changes in consumer shopping habits and growing awareness of sustainability are driving the €9 billion global aerosol packaging market to look for a gas-free alternative to aerosols that is cheaper, safer, more eco-friendly and that allows a wider variety of package forms. GreenSpense is bringing to market Eco-Drive, a cost-effective alternative to aerosol packages that eliminates their environmental, health and safety issues, opens a new world of packaging design and differentiation opportunities for brands and can be seamlessly implemented on existing production lines. The product provides an aerosol-like dispensing experience with many significant advantages: a cleaner environment, reduced manufacturing, transportation and handling costs, use of recyclable packaging, exciting new horizons for brand differentiation via packaging design freedom, and sidestepping the increasing regulatory restrictions being placed on the manufacture and transportation of aerosol packages. The product is compatible with existing aerosol filling equipment. European and international customers have already started working with GreenSpense on packaging their continuous-dispensing products with Eco-Drive. The project focus is to address the strong market demand for a gas-free and pressure-free continuous dispensing package and to take Eco-Drive from its current initial phase of paid-for commercial pilots, through large-scale commercial readiness in the European and global liquid-product-packaging market.

Keywords: aerosol dispensers,packaging liquids,voc reduction,sustainability,propellants,packaging and environment,packaging safety,continuous dispensing,green chemistry,branding,personal care products