Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unlocking urban barriers for disabled people (STAIRLESS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The STAIRLESS project aims to develop and commercialise the first electric wheelchair capable of climbing stairs and all kind of architectural barriers, thus representing an enormous step for the autonomy and independence of people with reduced mobility and positioning our company STUDIOEMME as the first company to market such a solution. Its uniquely engineered design, with sensors to verify the surroundings of the wheelchair and identify possible obstacles, together with its unique combination of wheels and caterpillars provides the user with complete autonomy to overcome architectural barriers in a safe and comfortable way. The STAIRLESS project will represent a quantum step for our company, as through it we expect to multiply by 4 our current revenues in the first five years of commercialization (up to €5.7 million), achieving profits of €2.2 million with a Return of Investment of 2.37. Moreover, it will allow us to create further jobs (by increasing our staff from 11 to 19 people) and boost the growth of our company within a sector in which we have a very limited presence: that of medical devices. STAIRLESS will also imply a significant impact in the wheelchair industry as current manufacturers will have to compete with our innovative product. Our target price, of €17,000, is well inside the price range handled by high quality powered wheelchair manufacturers (6,000-30,000€). Furthermore, our STAIRLESS wheelchair will provoke a major impact on the rest of the competitors who will probably start working on replicating our stair climbing capability in their own models. More importantly for us, thousands of wheelchair users will finally have a breakthrough solution that gives them complete autonomy of movement in any environment- indoors or outdoors, without any help or assistance.

Keywords: electric wheelchair,stairs,overcoming,climbing,architectural barriers,autonomy,disabled,independence
Additional Innovation support services for Enterprise Europe Network in Eastern France (EEN GRAND EST INNO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: France,France,France
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 342068.75
EU funding (EUR): 342068.75
Participants: 8
Project status: CLOSED

Providing Enhancing innovation management capacity services to high potential SMEs and Key account management services to beneficiaries of the SME Instrument in the 5 regions of Eastern France through an additional workpackage of the Enterprise Europe Network EEN GRAND EST - 649194 consortium for 2015 - 2016

Keywords: innovation management,sme instrument,key account management,enhancing capacity
Mushroom Body Expansion in Heliconius butterflies (MuBoEx)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2024-01-31
Duration (months): 72.0
Total project cost (EUR): 1499940.0
EU funding (EUR): 1135628.1
Participants: 2
Project status: SIGNED

The brain plays a central role in the production of adaptive behaviour. It must extract and integrate the most relevant sensory cues from the environment, and combine this information with memories of past experience to trigger appropriate behavioural responses. To fully understand the origins of behavioural novelty we need a detailed understanding of how behavioural differences are generated, both across evolutionary time and during development. This requires the integration of behavioural and neuroanatomical variation, and their genomic and developmental bases. Mushroom bodies (MBs) are the most enigmatic structures in the insect brain. They have ‘higher order’ functions, integrating sensory information and storing memories of past experience. MBs share a conserved ground plan, but their size and structure varies extensively across species. MB morphology is determined by the number of MB neurons, and the nature and extent of connections they make with other brain regions. As such, they provide a model for asking fundamental questions about how selection, development and functional constraints shape brain evolution. This project will establish a new study system in evolutionary neuroscience, Heliconius butterflies. MB volume in Heliconius is among the highest across insects, 3-4 times larger than typical for Lepidoptera, including closely related genera. The proposal represents a synthesis of four key objectives that will provide a cohesive understanding of MB expansion in Heliconius, encompassing both proximate and ultimate causes. Specifically, I will ask: i) How does MB expansion enhance behavioural function? ii) How do volumetric changes relate to differences in neuron number, density and connectivity? iii) What developmental mechanisms control region specific changes in neural proliferation? And iv) what is the genetic basis of MB expansion? Addressing these questions will provide profound advances in our understanding of brain evolution.

Keywords: brain evolution,learning and memory,mushroom body,neurogenesis
Designing the railway of the future: Fire resistant composite materials and smart modular design (Mat4Rail)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Germany,Germany,Spain,Austria,Austria,Germany,Germany,Spain,Spain,Switzerland,Switzerland,Türkiye,Sweden,Switzerland,Belgium,Belgium
Call: Innovative materials & modular design for rolling stock applications (H2020-S2RJU-OC-2017, 2017)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 3495216.25
EU funding (EUR): 3495216.25
Participants: 16
Project status: CLOSED

Europe’s railway industries require a step change in technologies and design for the next generation of rail vehicles in order to remain competitive globally. Innovative materials and modular design for rolling stock are considered to become key to success. Composite materials with their unique properties (lightness, repairabillity, corrosion resistance…) have demonstrated a high potential for lighter, more energy- and cost-efficient structural components in relevant sectors such aeronautic or automotive industries. However, currently available structural composites do not meet Fire, Smoke & Toxicity requirements of the railway sector, and thus cannot be used for the manufacturing of carbodyshell parts. Mat4Rail will face these challenges through a two-tier approach: In work stream I, our materials team (including resin producers, composite manufacturers, and experts on joining technologies and testing) will: i) synthesize novel fire retardant resins (epoxy, benzoxazine or hybrids) and manufacture composite batches; ii) modify fatigue and static load cases according to new requirements for polymeric materials; iii) further develop structural adhesive bonding combined with riveting and bolting for permanent and non-permanent joints and the repair of the new composites; and iV) assess novel design concepts for access door systems using new materials and joining technologies. In work stream II, our specialised design and engineering teams will develop new concepts for interior design of rolling stock including: i) plug and play systems which function like a limbic technical and power system for new electric utilities; ii) innovative lightweight seats and iii) a compact and ergonomic driver’s desk. Together, our multi-disciplinary consortium of 7 SMEs, 3 large industries, 5 RTDs and 1 UNI clearly has the experience and skills required to deliver innovations for uptake by the Shift2Rail JU members and the European railway industries.

Keywords: thermoset composites,flame retardant resins,access door system,plug and play sytems,driver desk,railways seat
Support to the Vice-Presidents of the ERC Scientific Council 2019 (ERC VP CSA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: ERC other
Action type: Coordination and support actions
Countries involved: Italy,Germany,Netherlands
Call: Support to the Vice-Chairs (H2020-IBA-ERC-VPRES-SUP-19, 2019)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 281597.5
EU funding (EUR): 281597.5
Participants: 3
Project status: CLOSED

The European Research Council (ERC) provides a competitive platform for investigator-driven frontier research at the European level. It is led by a Scientific Council (ScC) consisting of 21 eminent scientists and their President, and it is this council that independently establishes and oversees theERC's scientific management and the implementation of its Work Programme. This project aims to support the ERCVice-Presidents, who act on an honorary basis, in the efficient and timely achievement of the ScC's goals in 2019. This project will provide local administrative and advisory support to the three ERC Vice-Presidents.The staff supported by this project will provide analysis of the output of the ERCand the ScC to the Vice-Presidents, preparatory work for the meetings of the ScC, support with scientific outreach and representation, as well as maintaining a clear and efficient channel of communication between the Vice-Presidents and the ERC's Executive Agency. A key duty of the Vice-Presidents is maintaining the integrity of the ERC's evaluation panels, and the staff supported by this grant will facilitate this by providing detail information and analysis of potential panel members to the Vice-Presidents to allow them to take informed decisions on recruitment.The staff will also coordinate the invitation of new panel members and communicate with them during the recruitment process. The impact of the project will be to ensure the efficient and well-managed operation of the ScC. This support is required, as the duties of the Vice-Presidents demand a considerable portion of their time. By allowing the Vice-Presidents to effectively and efficiently perform their duties, this project will contribute significantly to the continued implementation of the ERC under Horizon 2020.

Keywords: erc scientific council,advisory support,administrative support,panel member recruitment,scientific outreach,liason with the erc executive agency
Living Impact on Fetal Evolution: Shelter-Analyze-Validate-Empower Regulations (LIFESAVER)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Research and Innovation actions
Countries involved: Ireland,Italy,Italy,Italy,Austria,Ireland,Italy,Malta,Sweden,Belgium,Belgium,Finland,France,Portugal,Portugal
Call: Fostering regulatory science to address combined exposures to industrial chemicals and pharmaceuticals: from science to evidence-based policies (H2020-LC-GD-2020-3, 2020)
Start date: 2021-11-01
End date: 2025-10-31
Duration (months): 48.0
Total project cost (EUR): 6136512.5
EU funding (EUR): 6136512.0
Participants: 16
Project status: SIGNED

In Europe about 75% of all neonatal deaths and 60% of all infant deaths occur in infants born preterm, and worldwide 450 neonatal deaths occur every hour. The number of preterm births is growing despite advances in medicine as more pregnancies are in the later age but also due to increasing environmental treats and lack of suitable treatments. In the LIFESAVER vision, every pregnant woman must have a proper living environment with the minimal risks to the fetus, safeguarded with scientifically justified regulations in use and control of potentially risky chemical and medicinal products, leading to healthier quality lives of the babies, overarching for generations. The LIFESAVER addresses the presently unmet societal and healthcare needs in creating and developing of a validated scientific knowledge base for the development and implementation of regulatory approaches relevant to maternal and fetal health. The objective is in creation of new, digitally cloned in vitro system for emulation of the pre-natal conditions in the vicinity of uterine/placental interface, capable of future high biofidelity prediction of safety and risk of substances towards unborn babies. LIFESAVER concept is based on an original idea of hybridization of several innovative technologies, integrating digital in silico/in vitro (biodigital twin) systems, enabling effective screening of chemicals and pharmaceuticals which might affect pregnant women health, reducing animal, preclinical and clinical testing, which is not presently possible with any other existing approaches to the same level of confidence. The outcomes are in design, manufacturing and deployment of a platform having key components of in vitro placental tissue for sufficient emulation of typical prenatal conditions. This aims to provide a solid scientific rationale for new regulations for chemical and pharmaceutical use relevant for the Green Deal vision.

Keywords: chemicals safety,women s and fetals health,pregnancy,drug safety,placenta,modelling,pharmacology,in vitro,design,optimization,bioprinting,biomechanics,pharmacovigilance,bioditigal twin
Negotiating Religion at the United Nations (NERELUN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2025-01-31
Duration (months): 36.0
Total project cost (EUR): 275619.84
EU funding (EUR): 275619.84
Participants: 2
Project status: SIGNED

Religion has become a salient issue within the United Nations (UN), especially in its human rights activities. This is especially due to a widespread perception of the growing threat posed by Islam, especially to the universality of human rights. The academic debate on the topic is highly polarised, with one view defending secularism as a basis of the universality of human rights and the suppression of religion, and the other seeing religion as a basis of universality and secularism as a threat to it; a more critical view questions both the neat distinctions between these rival views, and their internal coherence. Taking a different path, this project takes secular and religious visions as two sides of the same equation, and explores the question of how states negotiate the unending conflict between these two visions in relation to the construction of human right norms and institutions within the UN. It aims to write a revisionist history of the sources and consequences of the conflict between secular and religious vision in the field of human rights. The project proposes an entirely new theory to conceptualise the dialectic conflict between these two visions, and to select the case studies that exemplify the different configurations of the positions of states on the matter. These positions are then assessed in relation to five critical junctures in the development of human right norms and institutions, based on primary sources collected from UN archives and semi-structured interviews, analysed through the process-tracing method. In producing a theoretically informed and empirical investigation, the project aims to reframe the terms of the debate across disciplines, and allow for the formulation of innovative policy recommendations to help EU states cope with the tension between secular and religious visions domestically and at the UN, in a way that transcends binary or absolutist perspectives that dominate academic and public debates.

Keywords: human rights,united nations,religion,islam,universalism
Mushroom and biogas production in a circular economy (Mubic)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Denmark
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-04-01
End date: 2015-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Problem Growing certain biological foods requires a substrate such as straw, wood, chicken litter, horse manure and poultry litter for organisms to grow. Producing substrate today has low energy efficiency, has as a consequence that nutrients are lost, and is labour intensive. Solution – the innovation The innovation, a new production method for substrate, enables resources for biogas production and mushroom production to be used in a circular system that recovers energy and nutrients in an ecological and economically sustainable way. The project By creating a value circle between biogas production, mushroom production and energy and nutrient recovery it is possible to: • Generate high value growth media that is the basis for high value food production • Increase the feasibility of mushroom production by using a cheaper and transportable advanced substrate • Increase the feasibility of biogas production by re-entering the spent mushroom substrate back into biogas production • Increase energy efficiency from existing 50-55% to 80-85% of biomass in biogas production • Recover nutrients from biogas production In phase 1 the purpose is to prepare the construction of test-, pilot- and demonstration plant to be built in phase 2. Business model Advanced Substrate Technology (AST) holds the rights to the innovation, which will be licensed to business partner Panbo, who is a leading supplier of production facilities to the mushroom industry. Market and impact The global mushroom market is bn10.8€ and growing steady. Production in Europe is declining and rising in China due to lower labour costs. The targeted customers are new production facilities for mushrooms. The case for mushroom production is particularly compelling. Using the Advanced Substrate Plant enables automation of the very labour intense mushroom production, resulting in a 50% reduction in production costs with a payback time of 2-3 years.

Keywords: mushroom production,biogas production,bio substrate,biomass cycling
Next generation of Carrier Open SaaS for boosting e-Commerce economy (CANGOPAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-11-01
End date: 2017-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Business Opportunity: within the e-commerce market - specially for SMEs, cross-border delivery is considered to be an obstacle by 57% of retailers, while 46.7% of consumers declare they worry about the delivery in cross-border transactions, specially due to the high prices of the process.This causes a high risk barrier between the buyer and customers and obstructing so businesses –specially SMEs - international expansion. Besides market its fragmented and carriers has develop their own technological solutions obliging SMEs to be lock -in to one single shipper company. CANGOPAL added value: is an innovative technology that offers an open solution capable to provide an integrated parcel delivery to foster growth of the e-commerce SMEs in Europe. It enables e-commerce growth by providing easy access to any SME to carriers and good rates through a a single hub of carriers with an easy integration (based on APIs) to access to all of the available carriers in the platform. In other works: one integration to use them all instead of one integration for each carrier. Phase 1 objectives is to accelerate the market adoption and international penetration of CANGOPAL focus on preparing ourselves for the commercialization of at the international level (including route-to-market, marketing strategy, growth strategy, etc.) by evolving the product from TRL7 to TRL9 stage Impact : As a result of this project, CANGOPAL will grow considerably, generating 65 new qualified jobs by five years after the project ending and generating cumulative incomes of 43,8M€ and a EBITDA of 30,6M€ approx.

Keywords: carrier hub,e commerce logistics,open source
New Target and Drug Candidates for Alleviating Chronic Pain (ChronicPain)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-11-01
End date: 2021-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Chronic pain is one of the most significant unmet medical needs and health burdens in society today. This is due to limited analgesic efficacy of existing drugs, coupled with adverse side effects, and the development of tolerance over time. Moreover, patients may develop dependence on commonly prescribed opiate-based analgesics, with negative consequences and greatly increased societal costs. Hence there is a pressing need for new targets for drug development and new drug candidates to target chronic pain. During the course of our recently completed ERC grant we screened a number of mouse mutants for sensory neuron phenotypes that might arise from perturbation of neuron growth control mechanisms. We discovered an unexpected phenotype of reduced pain sensitivity in an importin knockout mouse line. Most strikingly, acute knockdown of this specific importin gene had an ameliorating effect in the chronic stage of a neuropathic pain model. Screening for drugs that might mimic this effect lead to the identification of a number of approved drugs that are candidates for repositioning as analgesics. In this PoC we will carry out the following objectives: (1) file for IP protection on the new pain drug target and the initially identified candidate analgesics; (2) validate the new drug target and drug candidates in models of neuropathic and/or chemotherapy-induced chronic pain; (3) devise an HTS-compatible assay for future screening of additional drug leads for chronic pain; and (4) carry out additional IP protection and pre-clinical validation steps to maximize the commercialization potential of this discovery.

Keywords: chronic pain,analgesia,target validation,drug discovery