Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
REGULATORY T CELLS AND TISSUE DAMAGE CONTROL (REGDAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 148635.6
EU funding (EUR): 148635.6
Participants: 1
Project status: CLOSED

Regulatory T cells (TREG) are critical players in the control of innate and adaptive immune responses while impacting as well on the functional output of parenchyma tissues. This later effect is exerted by tissue-resident TREG, via an ill-defined mechanism that modulates tissue damage control, that is, a protective response of parenchyma tissues that limits cellular dysfunction and/or damage imposed by inflammation and immunity. The central hypothesis to be tested under this proposal is that tissue-resident TREG modulate tissue damage control via a number of adaptive responses to cellular stress, which preserve the functional outputs of parenchyma tissues. Failure of tissue-resident TREG to modulate adaptive responses to oxidative and hypoxic stress should exacerbate the deleterious effects imposed by these forms of stress on parenchyma cells and as such promote the pathogenesis of immune mediated inflammatory diseases. Under this Marie-Curie fellowship we will address mechanistically how TREG receive signals from tissues exposed to oxidative and hypoxic stress and migrate to those tissues to modulate oxidative and hypoxic stress responses as to dampen tissue damage.

Keywords: treg,disease tolerance,foxp3,stress and damage response
Solutions for voice interaction towards natural crew assistant (VOICI)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Norway,Belgium,Norway
Call: Solutions for voice interaction towards natural crew assistant (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 1250750.0
EU funding (EUR): 1111250.0
Participants: 4
Project status: CLOSED

Within the 6th call of Clean Sky 2, the Voice Crew Interaction (VOICI) project aims to develop the technology that implements an intelligent voice crew interaction system as a "natural crew assistant" in a cockpit environment up to TRL 3. The main goal of the project is to provide a proof-of-concept demonstrator of a natural crew assistant, which is capable of listening to all communications occurring in the cockpit, either between crew members or between crew and ATC, recognizing and interpreting speech content, interacting with the crew and fulfilling crew requests, such as to simplify crew tasks and reduce workload. The topic leader has predefined: sound recording, voice recognition and artificial intelligence, as the three main technology components constituting the system, which should fulfil specific predefined requirements. Robustness against noisy environment, high recognition rate and requests interpretation are among the predefined requirements. An audio evaluation environment will be developed, which will allow the evaluation of the sound recording/voice recognition systems and natural crew assistant according to evaluation scenarios provided by the topic manager.

Keywords: acoustics,human machine interface,speech recognition,multimodal agent framework,microphone array,system integration
Terahertz Antennas with Self-amplified Spontaneous Emission (TERASSE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Israel,Italy,Italy,Finland,Belarus,United Arab Emirates,Philippines,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2018, 2018)
Start date: 2019-06-01
End date: 2024-09-30
Duration (months): 64.0
Total project cost (EUR): 358800.0
EU funding (EUR): 358800.0
Participants: 9
Project status: SIGNED

The project aims at studying the feasibility of Terahertz range emitters, with two main objectives: OB.1 – to investigate novel principles for nanoantennas, based on quantum effects enabling self-amplified emission in the THz range; OB.2 – to create a network of competencies on quantum and nanoelectronics, which includes academic and non-academic players, sharing knowledge and expertise retained by the partners. Several types of nanostructured materials will be investigated, such as graphene nanoribbons and graphene/polymer sandwiches, with embedded mesoscopic structures, or atomic chains (e.g., transition metals dichalcogenides and graphene dots and their chains) with interatomic coupling. First, new promising physical mechanisms will be studied, enabling the excitation of mesoscopic structures via shot noise, Rabi and Rabi-Bloch oscillations, and direct interband THz transitions induced by optical excitation. Then, new effective methods for mesoscopic systems will be developed, based on integral formulations that overcome the limits of the methods available so far. Finally, the project will design and implement specific experiments with the aim of observing and demonstrating the proposed physical mechanisms, and of providing proof-of-concept of the proposed THz devices. The final goal is that of bringing these novel solutions from Basic principles and Technology concept (TRL1-2) to experimental critical function and characteristic proof of concept (TRL3). A strong training and dissemination activity will be carried out, aimed at sharing competencies and expertise. Special emphasis is to be given to the interactions between theoretical and experimentalist Academic partners. The partners will transfer each others competencies and know-how in fields such as nanotechnology and quantum physics, in antennas and circuits modelling and design, in material and device fabrication and in experimental characterization.

Keywords: nano antennas,graphene,transition metals dichalcogenides,rabi waves,quantum effects,terahertz,applications
Credible HYbrid eLectric Aircraft (CHYLA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Netherlands,United Kingdom
Call: Scalability and limitations of Hybrid Electric concepts up to large commercial aircraft (H2020-CS2-CFP11-2020-01, 2020)
Start date: 2020-12-01
End date: 2023-05-31
Duration (months): 30.0
Total project cost (EUR): 837328.75
EU funding (EUR): 837328.75
Participants: 3
Project status: SIGNED

CHYLA - Credible HYbrid eLectric Aircraft aims to develop a landscape of opportunities and limitations of key radical hybrid-electric technologies (battery electric, fuel cell, but also considering non-drop in fuel technologies such as Hydrogen-H2, Liquified Natural Gas) and the "switching points" associated to scaling such technologies between different aircraft classes. These classes are: General Aviation, commuter aircraft, regional aircraft, short-medium range and large passenger aircraft, where the focus is on up-scaling the key-technologies. This landscape of design solutions is supported through a "credibility assessment" of assumptions underlying the application of these radical technologies, in different technology scenarios. Additionally, the impact of radical solutions will be assessed in terms of the viability of operations, economics and safety (certification). To achieve this, the project will use an approach of integrating novel airframe technologies with a hybrid electric energy network in order to apply credibility-based multidisciplinary design optimization (MDO). In order to provide feasible starting points for this landscape and the MDO, an integrated aircraft design approach will be used with physics-based design methods for the subsystem technologies.

Keywords: aircraft design,hybrid electric propulsion,fuel cell,cs23,cs25
Controlling Chemical Reactions For Carbon-Based Functional Materials Production on Surfaces (CFMOS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-08
End date: 2023-08-07
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

Functional materials are the bottleneck for almost all technologies, and they underpin directly or indirectly all the enabling ones. This project aims to synthesize with atomic precision on surfaces carbon-based materials with emerging functionalities that cannot be produced otherwise by traditional wet chemistry. CFMOS will focus on carbon nanostructures with predicted antiferromagnetic and open-shell character, frustrated magnetism and high efficiency in electron transport offering convenient materials for spintronic and electronic applications. The challenge of this project stems on the control of the complexity of the “on-surface synthesis” (OSS) strategy that can lead to their growth. In fact, for reactions involving multiple competing pathways as in this case, OSS often encounters obstacles. Based on the applicant previous experience, the applicant will focus on the smart design of molecular precursors and the kinetic chemical control to precisely steer the reactions pathway under a clean ultrahigh vacuum environment. Thanks to the combination of surface sensitive state-of-the art experimental techniques and theoretical support offered by the Host, the applicant will provide a complete characterization and understanding of the synthesized complex carbon nanomaterials. The overall mission of this fellowship will be to train the researcher to become an independent scientist through the achievement of well-defined scientific objectives and the development of managerial and outreach skills, preparing him for a leading position in academia.

Keywords: on surface synthesis,scanning tunneling microscopy stm,low dimensional nanostruture,surface reaction,characterization of local electronic properties
Phosphate homeostasis and energy metabolism in Dictyostelium discoideum (PHEMDD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Adenosine triphosphate (ATP) is the universal biological energy currency. Its cellular concentration is tightly regulated and depends on rates of glycolysis, oxidative phosphorylation, and obviously on phosphate availability. How is phosphate concentration regulated as a function of the cell’s demands? Inositol pyrophosphates, described as metabolic messengers, are excellent candidates to orchestrate phosphate homeostasis and energy metabolism. The research programme proposed here aims to elucidate the relationships between phosphate homeostasis, energy metabolism, and inositol pyrophosphates using the amoeba Dictyostelium discoideum as a model system. This organism has high levels of inositol pyrophosphates and inorganic polyphosphate (polyP) and, surprisingly, a comparatively low level of ATP, suggesting that inositol pyrophosphates may serve as a phosphate reservoir for ATP production. I will use a combination of metabolomics analysis, steady-state and dynamic flux analysis of ATP, polyP, Pi and inositol pyrophosphate levels, and a functional analysis of mitochondria to evaluate the impact of polyP and inositol pyrophosphates on the metabolic/energetic state of this organism. I will investigate the function of polyP, which is induced during development, to understand how and why phosphate homeostasis is so dramatically modified during this process. This will be the first comprehensive analysis of the relationships between phosphate homeostasis and energy metabolism in eukaryotes.

Keywords: phosphate homeostasis,energy metabolism,inositol pyrophosphates,polyphosphate
BabyMinder: Automatic diagnosis of neurocognitive impairment in infants (BabyMinder)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-07-01
End date: 2018-12-31
Duration (months): 18.0
Total project cost (EUR): 149780.0
EU funding (EUR): 149780.0
Participants: 1
Project status: CLOSED

Each year, millions of infants are born with neurodevelopment disorders resulting in cognitive deficits. Although infants are tested for their low-level (visual and auditory) abilities in the health care system, no standard tools exist for evaluating the development of cognitive functions, due to the absence of verbal report and explicit behaviour. Converging evidence now suggests that neural markers obtained from electroencephalographic (EEG) offer a valid approach for tracking the development of cognitive functions in the infant brain. The BabyMinder provides a proof-of-concept for a novel EEG portable system combined with a sensory stimulation application to track normal and impaired neurocognitive processing in infants. Its main purpose will be to help the diagnosis of neurodevelopmental disorders. The BabyMinder will be fully embedded in a wearable system and will feature active electrodes, which provide reliable EEG signals, yet do not require any electrolyte gel or humidification. Although several low-cost and fully portable systems have recently been developed for adults, none of these portable systems has been adapted to infant populations. It will also consist of a functional localizer for the automatic tracking of neurocognitive components. This functional localizer will consist of a stimulation protocol with various types of stimuli presented every few seconds, tapping specific levels of representation while the EEG device will monitor the deployment of dedicated neurocognitive components in real-time. The whole procedure will be embedded in children-friendly animations to keep infants interested. In time, a large database of participants will be collected and combined with state-of-the-art machine learning algorithms using a big data approach, improving the classification of normal vs. impaired neurocognitive processes. We aim to make the BabyMinder a standard tool for the diagnosis of neurodevelopmental disorders in the future.

Keywords: infants,development,wearable,neurocognition
Passive and Active Acoustic Leak Detection System (PAALD)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Ukraine
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

EXTRUSION IN MOTION, LLC (EIM) aims to commercialize its innovative “Passive and Active Acoustic Leak Detection (PAALD)” system which can significantly improve the accuracy and reliability of the detection of leaks of liquids in pipelines and storage tanks, helping to avoid associated environmental and economic damages to its users and the society overall. The detection of crude oil and petroleum products leaks has been selected as an introductory application, however the applicability of PAALD will be further enhanced to non-petroleum hazardous liquids transported by pipelines, as well as water. The novelty of the suggested solution derives from a unique fusion of two leak detection methods – i.e. the rarefaction wave and acoustic emission - which ensures high sensitivity with minimized false positive alarms, as well as higher cost-effectiveness of PAALD, compared to the competition.

Keywords: acoustic leak detection,crude oil leaks,sensors,pipelines,liquid leaks
organisation of CLoUdS, and implications for Tropical cyclones and for the Energetics of the tropics, in current and in a waRming climate (CLUSTER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Austria,France
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-06-01
End date: 2024-05-31
Duration (months): 60.0
Total project cost (EUR): 1078021.0
EU funding (EUR): 719343.28
Participants: 3
Project status: SIGNED

Few geophysical phenomena are as spectacular as tropical cyclones, with their eye surrounded by sharp cloudy eyewalls. There are other types of spatially organised convection (convection refers to overturning of air within which clouds are embedded), in fact organised convection is ubiquitous in the tropics. But it is still poorly understood and poorly represented in convective parameterisations of global climate models, despite its strong societal and climatic impact. It is associated with extreme weather, and with dramatic changes of the large scales, including drying of the atmosphere and increased outgoing longwave radiation to space. The latter can have dramatic consequences on tropical energetics, and hence on global climate. Thus, convective organisation could be a key missing ingredient in current estimates of climate sensitivity from climate models. CLUSTER will lead to improved fundamental understanding of convective organisation to help guide and improve convective parameterisations. It is closely related to the World Climate Research Programme (WCRP) grand challenge: Clouds, circulation and climate sensitivity. Grand challenges identify areas of emphasis in the coming decade, targeting specific barriers preventing progress in critical areas of climate science. Until recently, progress on this topic was hindered by high numerical cost and lack of fundamental understanding. Advances in computer power combined with new discoveries based on idealised frameworks, theory and observational findings, make this the ideal time to determine the fundamental processes governing convective organisation in nature. Using a synergy of theory, high-resolution cloud-resolving simulations, and in-situ and satellite observations, CLUSTER will specifically target two feedbacks recently identified as being essential to convective aggregation, and assess their impact on tropical cyclones, large-scale properties including precipitation extremes, and energetics of the tropics.

Keywords: deep convection in the tropics,self aggregation of deep convection
R-Exposome Chair: Unlocking the potential of RECETOX in Exposome research (R-Exposome Chair)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Czechia
Call: ERA Chairs (H2020-WIDESPREAD-2018-04, 2018)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 2494150.0
EU funding (EUR): 2494150.0
Participants: 1
Project status: SIGNED

The main goal of this ERA Chair project proposal is to develop new capacities for the Environmental Health research in the region of Central and Eastern Europe, namely at Masaryk University in Brno, Czech Republic, by establishing the excellent international scientist as an ERA Chair and a leader of new research programme on Environmental Epidemiology, Biostatistics and/or Bioinformatics. The new research group will focus on interpretation of available regional data on the environmental exposures and their impacts on population health, and contribute to development of new study programmes in the Environmental Health sciences including the Ph.D. school.

Keywords: environmental epidemiology,biostatistics,bioinformatics,integrative data mining,social epidemiology,epigenetics,chemical exposures,environmental risk assessment
Smart NIR Olive Oil Extraction Control and Measurement System (Almazara 4.0)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Olive oil’s nutritional and healthy qualities have positioned it as one of the fastest growing segments of the global food industry and its quality is regulated by EC and the International Olive Council based on different chemical and organoleptic markers. Thus in order to obtain the best quality during the extraction process, only mechanical actions are applied with no use of chemical solvents during the separation process, reducing the yield of the process which lowers significantly the margins for producers. Current solutions for ensuring highest overall extraction process efficiency and oil quality are off-line, time consuming and costly. Thus, there is a strong need for an in-line monitoring solution capable to produce rapid adjustments of the different production steps. Near infrared (NIR) spectroscopy has emerged as a rapid and non- invasive tool for such purposes. Nevertheless, commercialized NIR technologies fail to integrate a control solution of the extraction process efficiency. Almazara 4.0 is the first smart NIR system able to improve the efficiency of the extraction process by 35% in average, saving around €60k/olive mill per campaign. We have demonstrated through laboratory tests that our intelligent sensor can regulate the operation of the centrifuge decanter to achieve the maximum extraction of olive oil, while monitoring in-line the olive oil quality (free acidity and oxidation state) and its healthy organoleptic markers (phenolic content). This will save the mill’s operators considerable time and money while providing them valuable information about quality and healthy content in their olive oil production at any given time. In this regard, we deliver a ground-breaking product supporting “resource-efficient and cost-effective solutions to secure sufficient supplies of safe, healthy and high quality food” towards meeting “Sustainable and competitive agri-food sector for a safe and healthy diet” societal challenge addressed by Horizon 2020.

Keywords: olive oil,production loss reduction,real time compound measurement,lab test avoidance