Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Enabling Multichannel PArticipation Through ICT Adaptations (EMPATIA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Czechia,Portugal,United Kingdom,United Kingdom,Portugal
Call: Collective Awareness Platforms for Sustainability and Social Innovation (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2018-03-31
Duration (months): 27.0
Total project cost (EUR): 1483625.0
EU funding (EUR): 1483625.0
Participants: 8
Project status: CLOSED

Participatory budgeting (PB) represents one of the most successful civic innovations of the last quarter-century. At a time when voter turnout in Europe is lagging and public institutions struggle to maintain trust and legitimacy within a framework of growing budgetary cuts, PB has proved itself to be a powerful tool for citizens to join in the essential tasks of governing, not only as voters but also as decision-makers themselves. EMPATIA aims at producing the first ICT platform capable of fully encompassing both the decision-making cycle and the implementation cycle of PB whose integration is considered indispensable by literature as the main driver of the self-sustainability process. It will harness the collaborative power of ICT networks applied to PB, seeking to radically enhance the inclusiveness and impact of PB processes, enabling citizens, individually and collectively, to take deliberate and informed action for the public good. This will lower barriers to information and participation, deepening citizen engagement and trust in public institutions, collaborating alongside them to make their communities more sustainable. EMPATIA consists of multidisciplinary consortium, with expertise in adjacent fields – research and implementation of participatory and voting processes, ICT integration, evaluation of technological and societal impacts among others – that will include in its activities the implementation of three distinct PB Pilots, with citizens from the municipalities of Lisbon (Portugal), Ričany (Czech Republic) and Bonn (Germany), allowing a thorough analysis and validation of the EMPATIA platform.
A Theory of Reliable Hardware (ToRH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-08-01
End date: 2022-07-31
Duration (months): 60.0
Total project cost (EUR): 1472000.0
EU funding (EUR): 237000.0
Participants: 2
Project status: SIGNED

The complexity of computing hardware keeps increasing at a rapid pace, with no end in sight. With growing number of components and ongoing miniaturization, hardware engineers struggle with an increasing number and variety of faults, yet must guarantee correct operation of the system as a whole. This is hindered by a concurrent increase in design complexity, i.e., the trend of integrating ever more diverse circuits into larger systems, which results in a higher complexity of verifying the correctness of a given design - especially when providing for the possibility that some components may fail. The goal of this project is to develop a holistic mathematical approach to modeling fault-tolerant circuits and demonstrate its usefulness in practice. Such a framework will exhibit several advantages over the present methods, which are largely based on simulation and experimentation: (i) mathematical proofs offer parametrized guarantees, which implies that the derived building blocks can easily be re-used in varying configurations and translated to different technologies; (ii) it permits statements about general fault types, entailing that claimed properties do not rely on specific fault behavior (which depends on operational parameters and technology); and (iii) abstract, parametrized reasoning enables to design and optimize for long-term scalability. While this approach to fault-tolerance has been successfully applied in the area of distributed computing for decades, transferring it to low-level hardware design introduces new obstacles, such as very limited computational capabilities of the basic components and the potential for metastability. Overcoming these challenges will pave the way for highly dependable and scalable systems, and thus help in further sustaining the exponential growth in available computing power commonly referred to as Moore's Law.

Keywords: byzantine fault tolerance,self stabilization,metastability,complexity analysis of algorithms,hardware implementation,fpga prototyping,clock synchronization,routing,consensus
Targeting the epigenome: towards a better understanding of disease pathogenesis and novel therapeutic strategies in Multiple Sclerosis (Epi4MS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-06-01
End date: 2025-05-31
Duration (months): 72.0
Total project cost (EUR): 1998798.0
EU funding (EUR): 1998798.0
Participants: 1
Project status: SIGNED

Multiple Sclerosis (MS) is a leading cause of unpredictable and incurable progressive disability in young adults. Although the exact cause remains unknown, this immune-mediated disease is likely triggered by environmental factors in genetically predisposed individuals. I propose that epigenetic mechanisms, which regulate gene expression without affecting the genetic code, mediate the processes that cause MS and that aberrant epigenetic states can be corrected, spearheading the development of alternative therapies. We will exploit the stable and reversible nature of epigenetic marks, in particular DNA methylation, to gain insights into the novel modifiable disease mechanisms by studying the target organ in a way that has not been possible before. This highly ambitious project comprises three synergistic facets formulated in specific aims to: (i) identify epigenetic states that characterize the pathogenesis of MS, (ii) prioritize functional epigenetic states using high-throughput epigenome-screens, and (iii) develop novel approaches for precision medicine based on correcting causal epigenetic states. Our unique MS biobank combined with cutting-edge methodologies to capture pathogenic cells and measure their functional states provides a rational starting point to identify MS targets. I will complement this approach with studies of the functional impact of MS targets using innovative in vitro screens, with the added value of unbiased discovery of robust regulators of specific MS pathways. Finally, my laboratory has extensive experience with animal models of MS and I will utilize these powerful systems to dissect molecular mechanisms of MS targets and test the therapeutic potential of targeted epigenome editing in vivo. Our findings will set the stage for a paradigm-shift in studying and treating chronic inflammatory diseases based on preventing and modulating aggressive immune responses by inducing self-sustained reversal of aberrant epigenetic states.

Keywords: multiple sclerosis,epigenetics,dna methylation,epigenome editing,autoimmunity,adaptive immunity,neuroinflammation,animal models,functional genetics
Health, Environment, Agriculture, Rural development: Training network for LAND management (HEARTLAND)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Ireland,Ireland,Belgium,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-03-01
End date: 2023-08-31
Duration (months): 54.0
Total project cost (EUR): 1361335.68
EU funding (EUR): 1361335.68
Participants: 7
Project status: SIGNED

Livestock farming is increasingly in the spotlight because of its impacts on the environment and human health. Global livestock production, specifically ruminant farming, has been associated with land use change, methane emissions, climate change, deforestation and biodiversity loss. At the same time, consumption of livestock proteins exceeds total human protein requirements for a healthy diet in most European Member States. However, ruminants can convert biomass unsuitable for direct human consumption (e.g. grass resources) into valuable food, including essential macro and micro-nutrients for humans. While grazing, ruminants contribute to: maintaining the landscape and, in specific local conditions, to; enhancing biodiversity and increasing carbon sequestration. The contemporary industry challenge is therefore to develop livestock production systems that simultaneously enhance environmental sustainability and support a healthy diet. This is a knowledge-intensive process. Therefore, this European Industrial Doctorate (EID) programme – HEARTLAND+ will connect one of the most notable industry to the cutting-edge scientific knowledge while maximising the impact of the programme by working closely with experts in communication (to multiple audiences) and dissemination (to potential end-users). The objectives of HEARTLAND+ can be summarized as follows: 1. To train a new generation of creative, entrepreneurial and innovative PhD graduates in the multidisciplinary topic of soil-to-society 2. To design, implement and evaluate a soil, sward, and grazing farm management system aimed at maximising the positive impact on the environment, improving the nutritional and sensory quality of meat, and consequently improving human health in component and systems research 3. To upscale the findings to contribute to the sectoral development of sustainable production systems and land management 4. To communicate, disseminate and exploit the findings

Keywords: soil,sward,animal,meat quality,human health,environmental health,sustainable farming
Validation of diagnostic tests to support plant health (VALITEST)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Innovation actions
Countries involved: Italy,Italy,Germany,Italy,Belgium,Switzerland,Poland,Slovenia,Switzerland,France,France,France,Netherlands,Netherlands,United Kingdom
Call: Validation of diagnostic tools for animal and plant health (H2020-SFS-2017-1, 2017)
Start date: 2018-05-01
End date: 2021-10-31
Duration (months): 42.0
Total project cost (EUR): 3266749.8
EU funding (EUR): 2997867.51
Participants: 16
Project status: CLOSED

Regulated or non-regulated pests (bacteria, virus, fungi, nematodes, arthropods or weeds) are responsible of major crops’ losses. Accurate and reliable detection and identification of pests are essential to avoid or reduce economical costs and trade disruptions and to support surveillance activities. In recent years, numerous tests based on new technologies have been developed to meet the different needs. However, most of them are validated on an intra-laboratory basis, through limited test performance studies (TPS) or ring trials, and there is a need to further harmonize practices. The project aims at producing validation data and will include two rounds of TPS. The first one will include combinations of pest/test/matrix, prioritized based on the expertise of the project's consortium. The second round will include other combinations based on the needs expressed by various stakeholders. Priorities for validation will then be better aligned to their needs and to the market. To maximize the impact of the project, calls of interest will be organized to include in the validation programme, kits of suppliers outside the consortium and allow participation to the TPS of voluntary proficient laboratories. Current harmonized procedures in Plant Health for validation and organization of TPS will be improved by including appropriate statistical approaches and by adapting the process for new promising technologies, such as Next Generation Sequencing. Liaison with regional and international standardization bodies will allow large dissemination of validation data obtained in this project especially by their inclusion in harmonized diagnostic protocols. The outcomes of the project will stimulate, optimize and strengthen the interactions between stakeholders in Plant Health for better diagnostics and lay the foundations for structuring the quality and the commercial offers for plant health diagnostics tools thanks to a dedicated association and a quality charter.

Keywords: plant health,pest,diagnostic,detection,identification,validation,test performance study,validated protocols,next generation sequencing,training,reference material,proficiency
Privacy-Aware and Acceptable Video-Based Technologies and Services for Active and Assisted Living (visuAAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria,Germany,Ireland,Spain,Sweden
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-09-01
End date: 2025-02-28
Duration (months): 54.0
Total project cost (EUR): 3973703.4
EU funding (EUR): 3973703.4
Participants: 5
Project status: SIGNED

Europe is facing crucial health and social care challenges due to the demographic shift towards an ageing population and related economic impact from increased provision of care. Innovation in Active and Assisted Living (AAL) solutions has the potential to address these healthcare and social demands while profiting from the economic opportunities driven by the Silver Economy. Advances in computer vision have given video cameras the ability of ‘seeing’, evolving their functionality to become ‘smart cameras’. However, the monitoring using cameras can be seen as intrusive and violating rights to privacy, because of the concern that raw video images could be observed by unauthorised viewers or stored for inappropriate use. Acceptance of such technologies is also low because they create a sense of Orwellian “Big Brother” surveillance. The aim of VISUAAL is to bridge the knowledge gap between users’ requirements and the appropriate and secure use of video-based AAL technologies to deliver effective and supportive care to older adults managing their health and wellbeing. VISUAAL will seek to increase awareness and understanding of the context-specific ethical, legal, privacy and societal issues necessary to implement visual system across hospital, home and community settings, in a manner that protects and reassures users; outputs will stimulate the development of a new research perspective for constructively addressing privacy-aware video-based working solutions for assisted living. This aim will be achieved by providing a transdisciplinary and cross-sectoral combination of training, non-academic placements, courses and workshops on scientific and complementary skills. This holistic training to high achieving early stage researchers will be facilitated by the consortium, a community of researchers and industrial partners from different fields (computer science, engineering, healthcare, law, business, sociology) and other stakeholders (users, policy makers, public services

Keywords: active and healthy ageing,computer vision,assistive technologies,privacy,data protection,user acceptance
Exploiting the pathophysiology of the gut towards innovative oral peptide delivery strategies (NanoGut)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2025-06-30
Duration (months): 66.0
Total project cost (EUR): 1488937.5
EU funding (EUR): 1488937.5
Participants: 1
Project status: SIGNED

The development of new oral drug delivery systems that will enable the absorption of therapeutic peptides to the systemic circulation is one of the greatest current challenges for the pharmaceutical industry and is the ‘holy grail’ of peptide delivery. Improved novel drug delivery systems are of utmost importance in order to fulfill the potential of this route of administration in the treatment of chronic diseases (e.g. type 2 diabetes mellitus), where daily injections are often required. There are various advantages of using nanocarriers for this purpose: they offer protection against chemical and enzymatic degradation, controlled release, targeting, tolerability and/or improved uptake and translocation resulting in enhanced bioavailability and greater therapeutic efficacy. I was the first to demonstrate that lipid-based nanocarriers trigger endogenous glucagon-like peptide (GLP)-1 and GLP-2 secretion in vivo after orally administered to mice. This effect can be exploited to develop a novel and unconventional drug delivery nanosystem as a promising strategy for the treatment of gastrointestinal disorders (e.g. type 2 diabetes mellitus, Crohn’s disease, ulcerative colitis). There are significant gaps in current knowledge that need to be addressed to make this possible. I propose a series of studies to answer the following key questions: -First, can we develop a dual-action drug delivery nanosystem that synergizes its own biological effect and that of the encapsulated bioactive molecule? -Second, can we ameliorate type 2 diabetes mellitus (T2DM) and inflammatory bowel diseases (IBD) using an oral peptide-loaded dual-action lipid-based nanosystem? –Third, is this innovative strategy a viable alternative to current treatments in T2DM and IBD? By exploiting the gut pathophysiology, I propose an innovative therapeutic approach using cutting-edge advanced technologies to deal with an unmet therapeutical need in the treatment of gastrointestinal disorders.

Keywords: peptide oral delivery,drug delivery strategies
Line defects as building blocks of a defect-based quantum computer (Q-Line)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Luxembourg
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

A quantum computer is a device that exploits the quantum behaviour of its constituents ("qubits") to solve a computational problem. One of the most promising "hardware" options proposed to build such a device are point defects in solids, which hold promise of scalability and integration with current semiconductor technology. However, it remains challenging to position the point defects in a deterministic array and to integrate them into large networks. In order to address these two issues, we propose to use line defects (dislocations) as a “quantum bus” able to both create a deterministic pattern of relevant point defects and to connect them by means of localized phonons. Such idea represents a technological leap and paves the way for a quantum computer implementation that is fully defect-based, from its construction to its functioning. We remark that our proposal opens a completely new area of research, aligned with the quantum technologies flagship policy of the European commission and that will help putting Europe at the forefront of the development of quantum technologies. In order to carry out the project, it is necessary to combine the theoretical study of the stability and geometry of point and line defects with advanced electronic structure calculations of their spectroscopic properties. This is the basic strength of our proposal: it brings together the two complementary research profiles needed to carry the project. On the one hand, Dr Barragan is an expert on the physics of dislocations and their interactions with point defects and, on the other hand, Prof Wirtz is an expert on many-body perturbation theory. In addition, this project will open up a new research line for the Dr Barragan and will give him the opportunity to investigate problems at the interface of condensed matter/quantum technologies, increase his network of collaborations and thus serve as an important step preparing him to become an independent group leader in a European context.

Keywords: dislocations,quantum computing with defects,qubits,localized phonons,advanced electronic structure calculations