Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deciphering the Negr1 interacting network in physiological conditions and in psychiatric and neurodevelopmental disorders. (PSYNegrT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-03-07
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

There are no therapies for the core symptoms of most psychiatric and neurodevelopmental disorders. Compelling evidence indicates that most of these disorders feature aberrant neuronal connectivity. Importantly, the neuronal growth regulator 1 (Negr1) is associated with neuronal connectivity and diverse brain disorders. Thus, a better understanding of how Negr1 exerts its functions may reveal general principles underlying these pathological conditions. Previous results show that Negr1 does not operate as single entity. Negr1 functions by physically interacting with other proteins. In this context, PSYNegrT will investigate the hypothesis that the brain’s Negr1 interacting-protein network is remodeled in psychiatric and neurodevelopmental disorders. The fellow will investigate the role of specific Negr1 complexes in diverse brain disorders and their possible exploitation as drug targets. To this aim, he will identify and characterize the brain’s Negr1 interacting-protein networks by proteomic, biochemistry, and molecular biology studies. Computational and mutagenesis studies will reveal structural features for molecular interactions at the interface between Negr1 and selected partner proteins. This project will thus: i) produce the first exhaustive list of cerebral Negr1-interacting proteins in physiological conditions ii) identify the protein-protein interactions involved in Negr1-mediated pathological effects. With PSYNegrT, the fellow will increase his research skills and expertise in molecular biology and modeling, thus flourishing into an independent group leader. The project will be a breakthrough in our understanding of the causes of diverse brain disorders, and it will reveal certain general principles underlying their pathophysiology. This will facilitate structure-based efforts to design small molecules, peptides, or nanobodies to target Negr1-mediated protein-protein interactions involved in these disorders.

Keywords: negr1,schizophrenia,autism,depression,interactomic,molecular modeling
Madness in Fairy Land: (Re)Imagining Deviance in the Age of Psychiatry, 1820-1900 (MadLand)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-15
End date: 2024-10-14
Duration (months): 36.0
Total project cost (EUR): 269002.56
EU funding (EUR): 269002.56
Participants: 2
Project status: SIGNED

‘Madness in Fairy Land’ (MadLand) is an interdisciplinary exploration of fairy-tale and medical discourses on deviance and abnormality in 19th-century Britain, France, and the US. The project demonstrates the mutual knowledge-exchange between psychiatry and literature in interpreting, understanding, and (re)imagining deviance. In its comparative textual analysis of treatises on mental illness and fairy-tale narratives, MadLand provides the first transnational and translinguistic investigation: (1) of the ways in which 19th-century literary fairy tales reflected, incorporated, and questioned medical interpretations of moral and psychological deviance and of abnormal behaviour; and (2) of how the fairy-tale imagery and language of monstrosity, in turn, influenced and served as a point of reference for the codification of insanity by psychiatry in its formative period, 1820-1900. MadLand examines portrayals of diverse characters and themes in fairy-tale narratives that challenged hegemonic views of (hetero)normativity. It investigates literature’s creative reaction to the rigid dividing lines between normality and deviance as established by early psychiatry, then incorporated into the dominant cultural discourse, and still very much debated today. Exploring the emergence of psychological deviance and its representation in 19th-century fairy tales from a comparative viewpoint, MadLand contributes to current discussions on perceived norms and deviations of sexual orientation and gender expression, shedding light on medical and literary debates around ab/normal behaviour, monstrosity, gender, and sexuality in Europe and North America. As an expert in the relations between literature and medicine and 19th-century discourses of decadence, I am especially qualified to undertake this research, which will give me the opportunity to build on my existing knowledge in comparative literature as well as to acquire new skills and competences in fairy-tale and gender studies.

Keywords: fairy tale studies,19th century literature,children s fantasy literature,transnational literary studies,gender and sexuality studies,history of psychiatry
Integrative energy planning of urban areas: collective learning for improved governance (URBAN LEARNING)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Austria,Germany,Croatia,Poland,Sweden,France,France,Netherlands,Netherlands
Call: Enhancing the capacity of public authorities to plan and implement sustainable energy policies and measures (H2020-EE-2014-3-MarketUptake, 2014)
Start date: 2015-03-01
End date: 2017-11-30
Duration (months): 33.0
Total project cost (EUR): 1850062.5
EU funding (EUR): 1850062.5
Participants: 11
Project status: CLOSED

URBAN LEARNING gathers capitals and other large cities across Europe facing the common challenge of considerable population growth while being committed to significantly reduce fossil energy consumption and CO2 emissions. E.g. Stockholm grew by more than 12.000 people / a (1.5%); in the next 10 years Vienna has to build for 200.000 new people. Efficient and effective planning processes will be crucial for climbing this mountain. Vienna, Berlin, Paris, Stockholm, Amsterdam/Zaanstad, Warsaw and Zagreb aim to enhance the capacity of their local authorities on integrative urban energy planning, as response to new challenges from EU EPBD and RES directives as well as to changes of technologies and market conditions and the pressure to provide sufficient, affordable homes. The focus is put on the governance processes related to the (re-)development of concrete sites. While some cities already started ambitious urban development projects, the institutionalisation of these experiences is missing - despite awareness and willingness, due to lack of knowledge, lack of time and the need for collaboration across departments, which is not a common practice in many administrations in Europe. External stimulus is needed to overcome these barriers, and to address these issues collectively with external key stakeholders, such as DNOs and energy suppliers, and across cities. Focus will be on multi-disciplinary learning – concentrating on innovative technological solutions, instruments and tools as well as on innovative governance elements - and to capitalise this learning to institutionalise integrative urban energy planning. Improving the governance processes is expected to have significant energy impacts on homes and workplaces to be built and refurbished for over 3 million more people in the participating cities in the next 20 years: more than 1.700 GWh/a of energy savings and over 2.000 GWh/a renewable energy produced. Special emphasis is put on knowledge transfer to 150 more cities.

Keywords: integrative energy planning of urban districts,carbon neutral urban areas,governance processes,capacity building and collective learningn across stakeholders,growing cities,change management
Coastal and shallow-water monitoring through innovative low-cost technologies for blue growth in the Mediterranean (CoMPi)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Greece
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Phase 1 of CoMPi aims to assess the feasibility of an innovative service on integrated coastal monitoring, with the use of low-cost autonomous observational technologies, that will allow the estimation of the future coastline displacements and the evolution of the shoreline, contributing in this way to the development of the Blue Growth Strategy. Coastal tourism, a pillar of Blue Growth, is negatively affected by climate change in the Mediterranean and in other European coasts. Therefore, proper and sustainable management of the coasts is imperative. Although there are methods and mathematical models widely used to calculate the rates of shoreline changes, the reliability of their estimations depends directly from the amount and quality of the primary data which often have lower-than-required accuracy. For safeguarding blue growth and further developing tourism, innovative monitoring tools which use new methods and technologies for improving the quality and accuracy of the available geo-information providing thus high quality measurements of the shoreline positions are needed. Within Phase 1, a thorough market assessment will take place as well as the technical feasibility of the business idea of PLSurveryors. The factors affecting the pricing of the service and the profitability for the company will be examined. A business plan serving as a roadmap of how the envisaged service will be further created and developed in Phase 2 for its full commercialization will be drafted. The feasibility study will remove any bottlenecks in the ability of PLSurveyors to increase profitability through innovation and enlarge its clientele. Users of the service could be policy makers for develop tailor-made climate adaptation policies, private owners of tourist infrastructures, as well as real estate sectors of banks and insurance companies that shall be able to outline the threats on the coastal area and therefore calculate the potential risks of future tourism investments.

Keywords: blue growth,coastal and maritime tourism,coastal monitoring,climate adaptation,preservation of,coastal zones,mediterranean basin,innovative tools
Tracing carbon exchanges/fluxes between Arctic and Atlantic basins (CarbEx)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-11-01
End date: 2021-10-31
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: CLOSED

Dissolved organic matter (DOM) consists of a complex mixture of molecules generated from the degradation of living organisms. Surface waters of the Arctic Ocean (AO) have high concentrations of DOM and freshwater (FW) due to the massive supply from large rivers. Great part of it is exported to the Atlantic Ocean through the Fram Strait (FS). Climate change is expected to increase riverine FW and terrestrial DOM supply, with consequences to the hydrological and carbon cycles. However, such changes remain poorly understood and CarbEx will contribute to rectifying this. The three central goals are to (1) estimate the DOM and FW fluxes from the Arctic to the Atlantic Ocean through the FS, (2) assess their variability and (3) develop an approach to assess the amount of both terrestrial DOM and FW, from optical measurements of DOM. A major challenge is to obtain sufficient data from the region and CarbEx will apply three complementary approaches: oceanographic expeditions (OE), ocean color remote sensing (OCRS, satellite-based Earth Observation) and numerical modelling (NM). Riverine FW and DOC fluxes will be estimated using a combination of observations and NM. Hydrographic and biogeochemical data acquired during a series of OE conducted annually in the FS (Summer 2009–2018) is available. The in situ data will be complemented with OCRS and NM to develop a continuous time series, filling the temporal coverage gaps from OE, to analyse possible trends and links to climate change in the Arctic. CarbEx also has a non-academic character and will provide the necessary foundation to develop new technologies to monitor the FW and carbon dynamics in the AO and aquaculture sites, i.e. in situ multi-channel fluorometers. This aligns with the host’s strategy to develop observational technology and Arctic research, and with the EU’s goal for the IF programme about stimulating the creative and innovative potential through advanced training and international and intersectoral mobility.

Keywords: dissolved organic matter,arctic ocean,oceanography,freshwater export,biogeochemistry,ocean color remote sensing,numerical modeling
Satellites and nuclear information. Production, communication and reception of nuclear-related information generated with satellites. (NucSat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

In our societies in which information is ubiquitous, satellites are still a matter of national pride and prestige, but they are also scientific laboratories, commercial projects, services’ providers, and part of global information infrastructures. Satellites are part and parcel of knowledge society. In particular, satellite images and calibrated measurements contribute to generate technical information about nuclear accidents, as well as to convey the public perception of them, forge debates on nuclear energy, its management and its risks, and shape environmental, regulatory and political action. Satellite data are both resources that enable regulators and policy-makers to act during and after nuclear crises as well as instruments to communicate with the large public. But how policy guidance is carried out to manage nuclear situations and how public perception of nuclear risks is constructed from, through and with satellite data? By focusing on the information generated and consumed in the aftermath of two nuclear accidents (Chernobyl 1986 and Fukushima 2011), this project aims to explore in detail the processes that transform satellite raw data into knowledge, allowing us to understand how satellite information is produced, analysed, rendered evident, disseminated and consumed. Such historically informed comparative study will provide understanding of the historical evolution of the production, circulation and reception of satellite data and their actual impact in the contexts of both defining political action and framing public opinion related to nuclear issues. This innovative study will not only enhance our academic understanding of space, nuclear and information history (and their connections), but also alert us to how knowledge from space is generated as it is transformed into information that is used to advance multiple intellectual, institutional and policy-related objectives in different social and cultural contexts.

Keywords: satellite data,nuclear accidents,information society,science,technology and society,public understanding of science and technology,technology and risk communication
An EnhaNceD Common InfoRmatiOn Sharing EnvironMent for BordEr CommanD, Control and CoordinAtion Systems (ANDROMEDA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Strengthen security through border management
Action type: Innovation actions
Countries involved: Spain,Italy,Israel,Italy,Finland,Bulgaria,Bulgaria,Greece,Greece,Greece,Montenegro,Portugal,United Kingdom,Portugal
Call: Demonstration of applied solutions to enhance border and external security (H2020-SU-SEC-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 6009589.29
EU funding (EUR): 4999462.5
Participants: 20
Project status: CLOSED

The project aims to unlock the full potential of CISE, by validating in a long period of time CISE-compatible command, control and coordination systems from several Coast and Border Agencies. At the same time it is envisaged to further enhance, validate and demonstrate CISE by extending its scope for land borders and adapting relevant C2 solutions and associated services. This will be accomplished by extending the CISE data model based on the use cases and requirements and adapting state-of-the-art command & control systems for full compliancy with the enhanced model and CISE message exchange patterns. The project architecture will follow a hybrid scheme in order to allow the usage of the End User CISE Nodes/Gateways and at the same time to allow the testing and validation of the extended data model. The project will leverage on the developments, results and experience of the consortium from current and previous research projects (PERSEUS, CloseEye, MARISA, RANGER), from National Procurement projects of CISE Nodes and Adaptors and on the CISE infrastructure of the End Users.

Keywords: cise,eurosur,situational awareness,command and control
Characterizing the fitness landscape on population and global scales (CharFL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Austria
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 1998280.0
EU funding (EUR): 1998280.0
Participants: 1
Project status: CLOSED

The fitness landscape, the representation of how the genotype manifests at the phenotypic (fitness) levels, may be among the most useful concepts in biology with impact on diverse fields, including quantitative genetics, emergence of pathogen resistance, synthetic biology and protein engineering. While progress in characterizing fitness landscapes has been made, three directions of research in the field remain virtually unexplored: the nature of the genotype to phenotype of standing variation (variation found in a natural population), the shape of the fitness landscape encompassing many genotypes and the modelling of complex genetic interactions in protein sequences. The current proposal is designed to advance the study of fitness landscapes in these three directions using large-scale genomic experiments and experimental data from a model protein and theoretical work. The study of the fitness landscape of standing variation is aimed at the resolution of an outstanding question in quantitative genetics: the extent to which epistasis, non-additive genetic interactions, is shaping the phenotype. The second aim of characterizing the global fitness landscape will give us an understanding of how evolution proceeds along long evolutionary timescales, which can be directly applied to protein engineering and synthetic biology for the design of novel phenotypes. Finally, the third aim of modelling complex interactions will improve our ability to predict phenotypes from genotypes, such as the prediction of human disease mutations. In summary, the proposed study presents an opportunity to provide a unifying understanding of how phenotypes are shaped through genetic interactions. The consolidation of our empirical and theoretical work on different scales of the genotype to phenotype relationship will provide empirical data and novel context for several fields of biology.

Keywords: genotype to phenotype map,fitness landscape,epistasis
Social Inclusion and the Political Economy of Education: Building Social Capital in Ethnic Diversity (INCLUSION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Italy,Türkiye
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2350000.0
EU funding (EUR): 1003000.0
Participants: 2
Project status: SIGNED

Human migratory flows are currently at an unprecedented scale. The majority of these flows concern forced displacements, turning into long-term settlements in host countries, making ethnic diversity a permanent feature of our societies. Managed incorrectly, rapid changes in ethnic composition can harm host communities’ social capital and give ways to ethnic conflicts and polarization. Given that immigration will remain an inevitable global reality for the foreseeable future, designing and implementing inclusive social policies emerge as pressing policy imperatives. Leveraging the power of public education, the overarching goal of the proposed study program is to offer evidence-informed policy actions to help build ethnically diverse communities characterized by tolerance and inclusion rather than conflict and segregation. The proposal builds on a decade long research agenda to implement and test two uniquely designed educational interventions, one mitigative, the other preventative in nature. These interventions will involve two large-scale randomized controlled trials (RCTs) to be run in parallel for four consecutive years. The first study concerns a unique educational action to mitigate ethnic tensions and conflict in at-risk post-primary schools. The second study involves a pedagogical transformation intervention targeting primary school children who will progress into the post-primary schools targeted in the first study. Both RCTs are novel with respect to the content and delivery of the interventions, comprehensiveness of outcomes to be measured, sample size, and long-term follow-up opportunity. The results of this research program will: (i) generate much-needed evidence to design effective educational policies aiming at building social cohesion in communities afflicted by mass migratory flows, (ii) unravel for the first time the causal role of public education in raising tolerant and inclusive generations, free from ethnic conflict and segregation.

Keywords: social inclusion,inter ethnic cohesion,educational achievement,forced displacement,refugee integration