Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
From protein sequence to function – computational and experimental de-orphanization of uncharacterized enzymes in fungi (fORPHAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2023-02-20
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

Fast advances in genome sequencing and sequence processing technology leave ~30% of predicted proteins as orphans, meaning without known function or closely related enzymes. Being able to assign a function to such orphans opens avenues to select for and design powerful biocatalysts – individual enzymes, biosynthetic pathways or entire organisms. The herein proposed research aims at developing a de-orphanizing pipeline “fORPHAN” based on computational and experimental characterization of enzymes from the fungal kingdom. Fungi are known to be prolific producers of secondary metabolites, however, the study of the underlying biosynthetic gene clusters is still a fairly young field. The use of automated search and annotation pipelines is currently limited by the small number of experimentally characterized genes and gene clusters that can be used to train the algorithms. Therefore, I propose to use deep targeted database searches to identify key biosynthetic enzymes in the publicly available genomes of fungi. First targets will be the thus-far uncharacterized family of putative chalcone isomerases and the recently discovered family of type III polyketide synthases, which both have great potential for in vivo and in vitro applications. Several gene candidates will be expressed in vitro and in recombinant microbial hosts, and tested for activity on a range of substrates. Interesting candidates will also be characterized by X-ray crystallography. This research will not only yield biotechnologically-relevant catalysts but also provide the bioinformatic foundation for more challenging genome mining projects.

Keywords: flavonoid biosynthesis,biosynthetic gene clusters,biocatalysis
Non-intrusive solution for Obstructive Sleep Apnea Syndrome (Sleepwise)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The Obstructive Sleep Apnea (OSA) is a chronic disease that afflicts approximately 100 million people, however, nearly 80% of people with this condition remain undiagnosed. Sleep Apnea has serious medical consequences but it is also economically costly. In the USA alone the estimated economic cost of undiagnosed OSA is $149.6 billion. The diagnosis of OSA is typically made after a polysomnography (PSG), an expensive test that requires an overnight stay in a sleep laboratory wired to up to 15 different devices. Today the use of Home Sleep Tests are increasing due to are less intrusive and cheaper, however, they are subject to patient error in attaching the sensors, require previous training, are cumbersome and are not appropriate for children. Tarsio Medics is a technological company that has been working during more than 10 years together with the Pneumology unit of the Hospital Trias i Pujol to develop SleepWise, an innovative system for the exploration and diagnosis of OSA based on image processing. Our patented SleepWise system is non-intrusive, low cost, does not require training. It provides automatic analysis for sleep professionals, is more reliable because it can infer sleep/awake periods and is more versatile as it can also detect other nocturnal movements such as restless legs, parasomnias and epilepsy. We plan to monetize SleepWise offering a complete end-to-end service to doctors, hospitals and health insurance companies. The market potential is large: the global sleep apnea diagnostic system market is €341.7, €205.06 of them related with Home Sleep Tests. Currently we have a beta version of the SleepWise. Now we are applying to the SME Instrument Phase 1 to carry out a Feasibility Study to assess operational, technological and economic viability as well as to elaborate a Business Plan to define the business growth, sustainability, exploitation strategies and tactics to follow paving the way to a global market.

Keywords: obstructive sleep apnea,home sleep tests
Corporate Legitimacy in Digital Society: The Role of Citizens’ Judgments in Social Media (COLEDISO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-15
End date: 2018-07-14
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Corporate legitimacy, defined as the social acceptance of corporate behaviour, is constructed through a process of public deliberation. In recent years, social media technologies have enabled citizens to participate in this public deliberation by discussing, critiquing, and praising corporations. Management research about corporate legitimacy, however, has so far mainly taken into account the judgments of institutional evaluators, such as news media. By drawing on communication theories and an innovative method that combines sentiment analysis with discourse analysis of social media data, this interdisciplinary research project will examine thousands of citizens’ voices and their role in the process of legitimacy construction in digital society. The Researcher will be embedded within the vibrant research environment of the ETHOS Centre at the Cass Business School of the City University London, an institution with an excellent portfolio in education that is uniquely positioned academically and geographically. The research programme will provide access to academic expertise in an interdisciplinary environment as well as new research experience and training, providing an outstanding researcher with theoretical knowledge, methodological skills, and contact networks that will enable him to develop into a key contributor to international research in the interdisciplinary field of Corporate Social Responsibility (CSR). Thus far, the Researcher has published recent, high ranked journal publications that apply quantitative research methods. Through the acquirement and application of a qualitative method, more particularly discourse analysis, and collaboration with world-leading experts in legitimation processes, this research programme will propel the Researcher to the forefront of an interdisciplinary field emerging within management science and communication science. It will enable him to produce high quality research and to engage the general public with a lasting impact.

Keywords: corporate legitimacy,social media technologies,news media,corporate communication,sentiment analysis,discourse analysis,discursive struggles
Selectively Targeting Oscillations in Parkinson's disease: Causal effects of the beta-rhythm on motor control (STOP-Beta)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Parkinson’s disease is a frequent and disabling neurological disorder, which heavily impairs patients’ ability to perform and control movements. Electrical stimulation of a deep-seated brain region, the subthalamic nucleus (STN), has been shown to significantly improve patients’ motor function and quality of life. Recent technological advances in deep brain stimulation (DBS) render it possible to adjust electrical stimulation of the STN to ongoing brain activity, referred to as closed-loop DBS. Here, the implanted electrodes do not only send signals to the brain but also read out neural signals generated by the brain. Closed-loop DBS offers the intriguing possibility to specifically suppress pathological brain activity while leaving physiological activity unaltered. We propose an innovative and ambitious project, which the researcher will conduct in the Experimental Neurology group headed by Prof. Peter Brown at the University of Oxford, a world-leading laboratory in closed-loop stimulation. In this project we aim to test the hypothesis that closed-loop DBS that selectively targets pathological synchronous firing of neurons at 13 – 30 Hz, the so-called beta-rhythm, will interrupt neural activity related to motor impairment, but not normal functions of the brain. To this end, Parkinson patients with implanted electrodes in the STN will perform two tasks probing different aspects of motor control whilst receiving closed loop stimulation. We will simultaneously record activity from the STN and areas localized on the surface of the brain. This will allow us to assess how suppression of the beta-rhythm affects motor-related activity and connectivity in the human brain revealing it’s causal effects on motor function. Selective suppression of abnormal brain function and preservation of physiological brain mechanisms could be the key to obtain the best possible clinical benefit, whilst avoiding unwanted side effects in the treatment of Parkinson’s disease.

Keywords: parkinson s disease,deep brain stimulation,closed loop stimulation,subthalamic nucleus,motor control,electroencephalography,local field potentials,neural connectivity
Radical pair-based magnetic sensing in migratory birds (QuantumBirds)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,United Kingdom
Call: ERC Synergy Grant (ERC-2018-SyG, 2018)
Start date: 2019-04-01
End date: 2025-03-31
Duration (months): 72.0
Total project cost (EUR): 8561588.0
EU funding (EUR): 8561588.0
Participants: 2
Project status: SIGNED

The navigational and sensory abilities of night-migratory songbirds, travelling alone over thousands of kilometres, are absolutely staggering. The successful completion of these magnificent voyages depends crucially on the birds’ ability to sense the Earth’s magnetic field. Exactly how this magnetic sense works is one of the most significant open questions in biology and biophysics. The experimental evidence suggests something extraordinary. The birds’ magnetic compass sensor seems to rely on coherent quantum phenomena that indirectly allow magnetic interactions a million times smaller than kBT (Boltzmann’s constant multiplied by temperature) to be detected in biological tissue. QuantumBirds brings together quantum physics, spin chemistry, behavioural biology, biochemistry, and molecular biology in a unique, ambitious, imaginative and genuinely synergetic research programme that will prove whether the primary magnetic detection event occurring in the birds’ retinas involves the quantum spin dynamics of photochemically formed radical pairs in cryptochrome proteins. We will address three specific questions: 1. Are avian cryptochromes capable of functioning as magnetic compass receptors? 2. Do retinal neurons encode light-dependent, cryptochrome-derived magnetic information? 3. Are cryptochromes the primary magnetoreceptor molecules for magnetic compass orientation? Success in this endeavour will: (a) revolutionise our understanding of magnetoreception, the least understood of all biological senses; (b) firmly establish the emerging field of “Quantum Biology” and thereby reduce by six orders of magnitude the threshold for sensory detection of weak stimuli in biological systems; (c) prepare the ground for the development of a novel and powerful range of bio-inspired magnetic sensing devices; and (d) provide insights that could be applied in quantum computing and guide research into the potential effects of weak anthropogenic electromagnetic fields on human health.

Keywords: magnetoreception,quantum biology,spin chemistry,cryptochrome,migratory birds,spin dynamics,radical pairs,electrophysiology,quantum coherence,magnetic compass,bird navigation
Female Reproductive toxicity of EDCs: a human evidence-based screening and Identification Approach (FREIA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Estonia,Belgium,Sweden,Sweden,France,Netherlands,United States,Netherlands,Denmark,United Kingdom,United Kingdom
Call: New testing and screening methods to identify endocrine disrupting chemicals (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 6104476.25
EU funding (EUR): 6104476.25
Participants: 11
Project status: SIGNED

The FREIA consortium aims to close gaps in scientific knowledge on the mechanisms by which EDCs can affect female reproduction during specific life stages and will provide test methods to address this. The FREIA consortium has human tissue models that span the entire life cycle from fetal ovarian and adrenal tissues to child and mature ovarian follicles, that will be used identify human relevant biomarkers of EDC exposure. We will measure chemical exposures in follicular fluids and molecular profiles in granulosa cells from two IVF cohorts, and link these to fertility outcomes and patient journal information, including life-style factors and workplace. We will perform in vivo rodent studies to capture susceptible windows of exposure and identify novel endpoints for female reproductive toxicity that may be implemented in OECD test guidelines. We will provide in vitro test methods, according to OECD guidelines, for molecular and cellular events that have been implicated in female reproductive toxicity. These include ER-beta activity, GPER activity, ovarian-specific steroidogenesis, oocyte maturation and competency and hypothalamic pulsatile GnRH secretion. We will also develop QSAR models to predict interaction with aromatase and PPAR-gamma. By integrating our data from in vitro studies with primary human tissues, human exposure data from fetal and follicular fluid samples and our in vitro and in vivo research findings, the outcomes of FREIA are directly applicable to the human situation. AOPs will be developed that will form the basis for a test strategy to assess female reproductive toxicity upon exposure to EDCs, in a regulatory context. Furthermore, by expanding our scientific knowledge, the FREIA project will provide better information on EDC-related female reproductive health effects that will be used to improve reproductive health for women around the world.

Keywords: female reproduction,endocrine disrupting chemcials edcs,ovary,human biomarkers,screening,test methods,adverse outcome pathways,test strategy
Electric distribution grid identification based on complex network theory using GIS information and limited grid monitoring and smart metering (GridTIMES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-05-01
End date: 2024-04-30
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

GridTIMES explores innovative solutions for the accurate and up-to-date identification of power distribution network topology consequently a comprehensive grid monitoring. The EU priority of increasing the penetration of renewable energy sources in the power system has led to install a wide range of them into low voltage distribution grids. While the focus of power systems control and observation has traditionally been at the generation, transmission, and high voltage distribution levels, a need for accurate information of the network topology at the low voltage distribution network level is essential. Since generally, distribution system operators may not have an accurate and up-to-date knowledge of the distribution network topology, GridTIMES tackles this gap by proposing an identification methodology based on complex network theory using measurement data from metering infrastructures, end-users smart meter data, and GIS information. In addition to the grid topology identification, GridTIMES addresses other functionalities needed by distribution system operators such as detection of losses (non-technical, and technical losses), sustainable grid operation, system resiliency, renewable energy sources exploitation and etc. Moreover, GridTIMES determines the optimal status of switches for the optimal grid operation enabling distribution system operators to get a return on investment for their smart meters. Besides GridTIMES’s advances in the multidisciplinary research fields, it is expected to impact the EU power sector, the industry, and society as a whole, by contributing to the effective integration of renewable energy sources to smart grids in the industrial environments, and to the increase power systems' sustainability and reliability and the decrease of cost of distribution system operators consequently decrease electricity prices of end electricity users.

Keywords: topology identification,grid monitoring,complex network theory,optimal topology of grid,loss detection,sustainable grid operation,smart meter,power systems,smart grids
Mapping Normative Frameworks for EThics and Integrity of REsearch (EnTIRE)

Framework: Horizon 2020 — Science with and for Society
Programme: Develop the governance for the advancement of responsible research and innovation by all stakeholders, which is sensitive to society needs and demands and promote an ethics framework for research and innovation
Action type: Coordination and support actions
Countries involved: Germany,Spain,Ireland,Germany,Norway,Belgium,Croatia,Hungary,Hungary,Netherlands,United Kingdom
Call: Mapping the Ethics and Research Integrity Normative Framework (H2020-SwafS-2016-1, 2016)
Start date: 2017-05-01
End date: 2021-10-31
Duration (months): 54.0
Total project cost (EUR): 3770000.0
EU funding (EUR): 3770000.0
Participants: 12
Project status: CLOSED

Our aim is to create a platform that makes the normative framework governing Research Ethics and Research Integrity (RE+RI) easily accessible, supports application in research and evaluation, and involves all stakeholders in a participatory way, thus achieving sustainability. The platform will foster uptake of ethical standards and responsible conduct of research, and ultimately support research excellence and strengthen society’s confidence in research and its findings. This project has three unique features: 1. Stakeholder participation and community engagement The first unique feature is the iterative, ‘bottom up’ approach, making explicit normative experiences of local stakeholders and principles embedded in local standards, rules and practices, and enabling a structuring of data that fits research and evaluation practice, providing useful, accessible information for local users. 2. Focus on (diversity of) RE+RI practices The second unique feature is acknowledging the diversity of practices within and between countries and disciplines. Through normative analysis, differences wil be made explicit and open for comparison and deliberation. By using various methods of case analysis, prominent RE+RI cases from practice will be made accessible and scenarios will be developed. This will result in a structuring of data, based on their relevance for actual use by researchers. 3. Interactive self-sustainable Wiki-platform The third unique feature is the development of an online platform that is dynamic, customer-tailored, up-to-date and self-sustainable. Based upon the MediaWiki approach, committed to open source and open data, the platform steers a user through its content based on what he seeks and what he needs to know. The platform will be adapted and further developed using the latest novelties in knowledge engineering (data mining). It will be owned by the RE+RI community, which will ensure that it is up-to-date and sustainable.

Keywords: interactive platform,policy diversity,stakeholder participation,community engagement,wiki approach,open access,training resources,normative analysis of rules and regulations,case analysis
Portable Ion Devices for Mobile-Oriented Next-generation semiconductor Technologies (PIEDMONS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Austria,Austria,Italy,Switzerland
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2018-07-01
End date: 2021-12-31
Duration (months): 42.0
Total project cost (EUR): 2466245.0
EU funding (EUR): 2466245.0
Participants: 5
Project status: CLOSED

The PIEDMONS project addresses breakthrough innovations for the design and manufacturing of affordable new generation quantum devices: • The development and the testing of a portable ion-trap reproducible in large scale, and based on low-cost semiconductor MEMS technologies. • The development and testing of a novel quantum secured partioned Electric Electronic architecture exploitatable in a multitude of sectors With INFINEON Technologies, world leader in MEMS semiconductors, and two leading edge University in the field of Quantum computing (University of Innsbruck and ETH Zurich) the PIEDMONS project aims to the ambitious and long-term, but at the same way concrete and plausible goal of designing, implementing, experimenting and finding first applications for the basic building blocks of future quantum computers. Thanks to the experience of a high-tech SME (IFEVS) well known in the European Research Arena, it aims to the challenging objective of implementing first applications of these technologies in the huge market of consumer nomadic devices safe and secure, firstly in the mobility sector. The expected results of the project will establish the baseline of new scientific and technological research and future uses, which cannot yet be anticipated, but for sure will strengthen the European leadership in a sector that is expected to be strategical over the forthcoming decades. Demonstration of the feasibility of GPS-free positioning, portable atomic clocks, quantum cryptography and security in the short distance are the very challenging objectives in which the PIEDMONS project will measure and validate its performances. The project will involve a large audience and diverse actors in the scientific community and in the stakeholders through ad-hoc dissemination actions, while at the same time generating and preserving strategic Intellectual Property.

Keywords: portable quantum devices,ion entangling,mems,nomadic sensors,semiconductor manufacturing,consumer application