Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Early diagnosis, treatment and prevention of mood disorders targetting the activated inflammatory response system (MOODINFLAME)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Netherlands,Germany,Germany,Netherlands,Austria,Belgium,United Kingdom,Italy,Ireland,United Kingdom,France,Sweden,Belgium,Germany,Netherlands,Bulgaria,Germany
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2008-11-01
End date: 2013-04-30
Duration (months): 54.0
Total project cost (EUR): 13761545.68
EU funding (EUR): 10235585.0
Participants: 21
Project status: CLOSED

Partners come from 10 European countries to achieve two main objectives: A) The further exploration of 3 animal models (the OBX rat, GS rat and NOD mouse) characterized by an activated immune response system (IRS), an abnormal tryptophan catabolism and a depressive-like behaviour to study the pathogenesis of inflammation-related mood disorders and the efficacy/working mechanism of anti-inflammatory and tryptophan metabolism restoring drugs. B) The in-parallel study of mood disorder patients to validate two sets of already developed biomarker tests to identify patients and individuals at risk for a mood disorder and characterized by an activated IRS to be able to treat these patients/individuals with drugs counteracting the consequences of the activated IRS/disturbed catabolism of tryptophan. Five strategic approaches (broken down in 12 workpackages) are used: 1) Study of the animal models for depressive-like behavior and aberrancies in monocytes/ macrophages, the tryptophan metabolism and the microglia-astrocyte-neuron interaction. 2/3) The validation of a high-throughput biomarker mRNA blood monocyte signature test and a biomarker test to detect an abnormal tryptophan catabolism. 4) Correlation studies between the outcomes of these biomarker tests in patients to various clinical variables, a.o. gene polymorphisms and the brain scan. 5) The therapeutic targetting of the activated IRS/abnormal tryptophan catabolism using a PDE4 inhibitor, a COX-2 inhibitor and a KMO-inhibitor in the animal models and in a phase II intervention study in depressed patients. Novel approaches are the prospective assessment of patients/individuals to identify whether changes in the IRS have any prognostic value and that the program aims at a personalized treatment of patients on the basis of their activated IRS. We heavily rely in this on the study of the animal models, which allow us to test anti-inflammatory therapeutics and to know their mechanism of action at the brain.

Keywords: monocyte,inflammation,tryptophan,biomarker,diagnosis,treatment,mood disorder,animal model
Health system stewardship and regulation in Vietnam, India and China (HESVIC)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: United Kingdom,Belgium,Netherlands,Viet Nam,China,India
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-07-01
End date: 2012-12-31
Duration (months): 42.0
Total project cost (EUR): 3727436.8
EU funding (EUR): 2999894.0
Participants: 6
Project status: CLOSED

The proposed project aims to investigate stewardship and regulation as it relates to governance of health systems in policy and practice. It aims to do so by developing an integrated approach to improved stewardship and regulation in health services in Vietnam, India and China, in order to support policy decisions in the application and extension of principles of accessibility, affordability, equity and quality coverage of health care in the three countries. The health systems of Vietnam, India and China include a mix of types of health care providers including public and private sectors. The private sector has grown rapidly in recent years with implications for equity and access. Previous research in the three countries suggests that the stewardship and regulation capacity of the three governments is pivotal in improving policies regarding accessibility, affordability and quality coverage of health services. The project will use maternal health as a case study of stewardship and regulation of health care services. Maternal health is one of the key areas for policy and health care delivery in low and middle-income countries and is included in the Millennium Development Goals. The choice of Vietnam, India (one state) and China (one province) as study sites has been based on their high rates of overall maternal ill-health, and the spectrum of contextual issues that determine the need for adequate stewardship and regulation. The project will evaluate stewardship and regulation within and across the study countries, will identify gaps and will suggest ways of improving stewardship and regulation. The outputs will include policy guides for national and international health policy makers and recommendations for national standards of stewardship and regulation. The project will contribute to improved health policy decisions related to the provision and financing of equitable maternal health services within Vietnam, India, China and wider.

Keywords: health system,stewardship,regulation,governance,health policy,vietnam,india,china,asia
Molecular coding and subset specification of dopamine neurons generating the the meso-limbic and nigro-striatal system. (MDDANEURODEV)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Netherlands,Sweden,Germany,Spain,Germany,France,Italy
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-01-01
End date: 2012-03-31
Duration (months): 39.0
Total project cost (EUR): 3420935.0
EU funding (EUR): 2582749.0
Participants: 7
Project status: CLOSED

This project aims to elucidate the molecular coding of meso-diencephalic dopaminergic (mdDA) neurons forming the complex meso-limbic and nigro-striatal dopaminergic system in the vertebrate central nervous system. Recent advances in molecular and developmental biology have shown that this system harbors u multitude of functional units that are defined by spatial and temporal cues and are represented by specific molecular codes. These codes are essential to understand specific mdDA neuronal pathology as Parkinson's diseases and schizophrenia. In this collaborative project we gather the expertise on early and late development, cross species molecular-coding conservation, migration and axonal pathfinding to capture the significance of the understanding of mdDA neuronal development to generate a real advance in clinical understanding and treatment of mdDA pathology.

Keywords: dopamine,mesencephalon,diencephalon,ventricular zone,development prosomers parkinson,schizophrenia
Health systems and long-term care for older people in Europe – Modelling the INTERfaces and LINKS between prevention, rehabilitation, quality of services and informal care (INTERLINKS)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: Switzerland,Denmark,France,Finland,Germany,Germany,Spain,Netherlands,Slovakia,Slovenia,Sweden,United Kingdom,United Kingdom,Austria,Greece,Italy
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2008-11-01
End date: 2011-12-31
Duration (months): 38.0
Total project cost (EUR): 3894297.2
EU funding (EUR): 2985919.0
Participants: 16
Project status: CLOSED

The objective of this 3-year project is to construct and validate a general model to describe and analyse long-term care (LTC) systems for older people from a European perspective. The particular aspects of the different emerging national models that currently address long-term care needs in Europe will be used to show how the links to health care services, the quality of LTC services, the incentives for prevention and rehabilitation, and the support for informal carers can be governed and financed to enhance structures, processes and outcomes of LTC systems. Based on the assumption that LTC systems in Europe have only started to develop at the boundaries of health and social care, the project will focus on the elaboration of concepts, indicators and models for policies and practice at the interfaces and links between health systems and LTC. Good practice determinants will be identified and validated across countries. A European ‘state of the art’ model for describing and analysing long-term care provision will thus be constructed as an analytical toolbox that takes into account pathways of reform policies at any stage of a national LTC system’s development. The project outcome will guide policy analysis and design, permit comparison and will substantially broaden the scientific base that supports the Member States to better organise their health and LTC systems. It will also integrate the professional and the non-professional domain with inputs from a wide range of stakeholders by means of National Expert Panels and European-level Sounding Board Conferences. The project will be carried out by a consortium of 17 partners from universities, national and international research institutes with international and interdisciplinary expertise, also in cross-national research. The consortium represents 14 Member States covering different welfare regimes and geographical domains to allow for the regional and developmental, path-dependent differences to be addressed.

Keywords: health and long-term care,older persons,prevention,rehabilitation,quality of services,informal care
Gene- Environment Interactions in Heart Development (CHEARTED)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Netherlands,Belgium,United Kingdom,Netherlands,France,Australia,Norway,Germany,United Kingdom,Netherlands
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2009-01-01
End date: 2012-12-31
Duration (months): 48.0
Total project cost (EUR): 3943826.6
EU funding (EUR): 2689903.0
Participants: 11
Project status: CLOSED

Cardiovascular malformation (CVM) is the commonest cause of childhood death in developed countries. In the EU there are 51,000 new cases each year and two million affected individuals. Yet, despite intensive research, the cause of 80% of CVM remains elusive. The mission of CHeartED is to identify genetic and environmental pathways that can be modified with the goal of reducing preventable CVM incidence. Epidemiological studies have shown that the stress of maternal hypo or hyperglycaemia increases the incidence of CVM. We plan a genetic association study in individuals with and without CVM born to diabetic mothers, to test whether genetic variants are associated with CVM. A similar study, without prior risk hypothesis, addresses tetralogy of Fallot, a CVM, which requires surgery in early life. These studies will reveal common genetic variants associated with CVM and thus add to existing knowledge on the aetiology of CVM. Moreover, the identification of genetic factors that differ in the context of maternal diabetes will disclose any associations in genetic pathways influenced by environmental factors. RNA expression studies in the mouse to identify new genes and pathways involved in outflow tract malformations and maternal diabetes associated with CVM, will complement the human studies. Finally, we will develop a 3D atlas of gene expression patterns and cardiac morphology at key developmental stages that will serve as a morphological framework. Central to our proposal is the development of a bioinformatics tool complemented by an open-access Wiki-based database. The bioinformatics tool will combine the sequence data and expression data generated by the human and mouse studies with morphology and literature to prioritize genes and generate hypotheses. The Wiki, which will contain existing and new genetic and environmental knowledge on heart development, will be an aid for many groups working on cardiovascular development and a novel means of disseminating our findings

Keywords: heart,malformations,development,genome wide linkage analysis,rna profiling,genetic variations
Mechanisms of Microglia Synapse Communication (MicroSynCom)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1687476.0
EU funding (EUR): 1687476.0
Participants: 1
Project status: SIGNED

Microglia are the resident tissue macrophages of the brain and represent cells of the innate immune system. Looking at microglia from the immunological perspective, much is known about their role during inflammatory processes, factors that activate them and how they response e.g by releasing cytokines to mount an inflammatory response. This response has been shown to be detrimental during disease processes and lead to pruning/loss of synapses, a task microglia carry out also during development. Although microglia obviously play an important role in synaptic pruning and loss, it remains an open question, whether microglia are involved in the process of synapse formation under physiologic conditions. Therefore, the main hypothesis of MicroSynCom is that microglia represent the mediator of synapse formation or linker between pre- and post-synapse: sensing neurotransmitter release at highly active pre-synaptic sites and actively orchestrating the formation of new spines from the dendrite. I propose to investigate and reveal the underlying mechanisms of this tripartite microglia synapse communication process. Therefore, we will use two-photon stimulated emission depletion microscopy (2P-STED), novel viral and genetically encoded sensors for neurotransmitters, as well as optogenetic and chemogenetic manipulation tools. These methods will be combined with behavior test in freely moving, but also head-fixed mice to visualize microglia mediated synapse formation in awake mice. This will allow us for the first time to visualize, investigate and reveal the mechanisms establishing this novel role of microglia as the mediator of synapse formation in life animals and relate it to physiologically relevant neuronal network rewiring.

Keywords: microglia,synapse formation,dendritic spine,rewiring,two photon,in vivo imaging,learning and memory
An innovative, energy-efficient two-step manufacturing process, EcoForm, to produce CPET (Crystalline Polyethylene Terephthalate) trays for use in the food packaging industry. (EcoForm)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2015-06-01
End date: 2015-10-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

GR8 Engineering Limited (GR8) is a UK based SME with 85 years of combined experience and specialisation in injection moulding, injection compression moulding, stretch blow moulding and the application of Coralfoam technology. GR8 was incorporated in 2010 with the sole ambition of producing high quality plastic food packaging, specifically CPET (Crystalline Polyethylene Terephthalate) ready meal tray, using our novel EcoForm process. The UK ready meal industry is worth £2.6B (BBC News, The Rise of Ready Meals, Feb 2013: www.bbc.co.uk/news/magazine-21443166) and 1.3B black (CPET) trays are used in ready meal packaging in the UK annually. (Kent CC News Bulletin, pg 1: http://www.kent.gov.uk/__data/assets/pdf_file/0015/15018/KRP-press-release-M-and-S-Sainsburys-03-July-2014.pdf). Our first target market is food packaging and provides enormous commercial potential for GR8 within the UK, Europe and globally. We know our industry, our market drivers and our buyer needs, and we aim to revolutionise the thermoforming industry with our unique EcoForm technology, growing our business to over £10M per annum in royalties and machine revenues by 2020. We will patent our processes and scale up our business to become a high-growth SME, recruiting new expert staff to enable this. We require funding to refine and commercialise our EcoForm technology, which has been proven using a single cavity prototype of the injection mould machine and an initial prototype of the thermoforming system. We aim to progress our EcoForm process from a single cavity prototype mould to an 8 < 16 cavity production mould. Our project will drive growth and innovation into a greener food packaging sector and enable us to develop a finalised prototype in readiness for commercialisation. EcoForm has been designed with a unique environmentally based approach that offers; reduced materials wastage, faster production rates and improved design flexibility; and promises cost-effective, high volume manufacturing.

Keywords: injection moulding,blow moulding,compression moulding,thermoforming,low energy,hybrid,food packaging,green tech,cpet
The Neutron Electric Dipole Moment: pushing the precision to understand the matter-antimatter asymmetry (NEDM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France,France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2022-09-30
Duration (months): 66.0
Total project cost (EUR): 1498840.0
EU funding (EUR): 1498840.0
Participants: 3
Project status: CLOSED

The existence of a permanent electric dipole moment (EDM) of the neutron, or any subatomic particle, would have far reaching implications connecting particle physics with cosmology. Time reversal invariance and CP symmetry would be violated. A new fundamental interaction producing the EDM, that is, deforming the charge distribution inside the neutron, could also have generated the matter-antimatter asymmetry in the early Universe. After 60 years of evolution, techniques to measure the neutron EDM are now so evolved that experiments are sensitive to microphysics associated with an energy scale beyond that accessible at the LHC. This situation offers a high likelihood of discovery for the next generation of experiments. In the same time, any improvement in precision is technically challenging. The control of the magnetic field must surpass that of the state of the art of atomic magnetometers. The n2EDM project aims at improving the precision by an order of magnitude or more. Systematic effects need to be controlled at an unprecedented level. In particular, the use of a mercury co-magnetometer based on the precession of 199Hg spins induces a set of subtle false effects due to the relativistic motional field. I propose to initiate a comprehensive program to master these systematic effects beyond the current research program. In particular, the proposed project includes a precise determination of the 199Hg magnetic moment with a precision of 0.1 ppm. To this end, I will attempt a novel approach: combining mercury and 4He magnetometry in the same cell. As a by-product, this will also produce an improved determination of the neutron magnetic moment, a quantity of interest for metrology. The cross-check I propose will prove that all disturbances on the neutron or mercury spins are mastered at the sub-ppm level, a decisive step in the quest for the neutron EDM.

Keywords: baryogenesis
Coordination between cell identity, tissue mechanics and proportionate patterning during vertebrate eye formation (MechaPattern)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-08-25
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

The development of an organ requires the precise coordination between pattern formation, morphogenetic movements and the final size of the system. Significant progress has been made in understanding these processes independently. The aim of this proposal is to integrate this information by analyzing coordination hubs, such as the crosstalk between YAP/TAZ and Wntβ-catenin pathways during the specification of the identity and the mechanical properties of the cell. I will use the development of the vertebrate eye as a defined paradigm. To identify intrinsic and relevant properties of this system, the two most powerful and amenable models of eye morphogenesis will be analyzed: the self-generation of 3D optic cups from mouse Embryonic Stem Cells and the in vivo development of the teleost eye. The plan is to generate a spatiotemporal activation map of the main determinants of eye identity and use them to link morphogen signaling with key morphogenetic processes in specific cells. This will be the groundwork to identify the role of retinal pigmented epithelial (RPE) cells during optic cup folding, the context that I will use to understand both the coordination between morphogen patterning (Wnt) and mechanical properties (Yap) of the retinal precursors, and between proportionated patterning and eye size (scale-invariant mechanisms). This proposal relies on the collaboration of multiple experts from the host institute and on the use of already developed bona fide protocols, reporter lines and signaling perturbations experiments, but revisited with cutting-edge technologies, such as light sheet microscopy and computational modeling. Thus, it is an extremely innovative but feasible project to understand deep-root questions of organ formation. Moreover, this interdisciplinary project will open unprecedented opportunities in the field of organ regeneration from a comprehensive morphogenetic perspective, which will be the foundation of my future independent research.

Keywords: eye morphogenesis,mechanical forces,patterning,morphogen,scale invariance,zebrafish,medaka,mescs derived optic cups,catenin pathway,taz pathway