Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Translating Science into Policy: A Multisectoral Approach to Adaptation and Mitigation of Adverse Effects of Vector-Borne Diseases, Environmental Pollution and Climate Change on Planetary Health (PLANET4HEALTH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: Research and Innovation actions
Countries involved: Italy,Serbia,Netherlands,Norway,Portugal,South Africa,Spain,Belgium,Ireland,Austria,Germany,Greece
Call: Planetary health: understanding the links between environmental degradation and health impacts (HORIZON-HLTH-2023-ENVHLTH-02, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 5925130.0
EU funding (EUR): 5925130.0
Participants: 17
Project status: SIGNED

PLANET4Health provides new knowledge and tools on environment degradation and its impact on human animal and ecosystems health. The project results will support policy making process and citizens awareness on sustainable planetary health, climate and environmental policies and adaptation and mitigation strategies to natural hazards. PLANET4health will develop collaborations from a large variety of organizations from the: environmental and climate science, public health, epidemiology, veterinary medicine, social, political and economic science, engineering, law and ethics, and communication, to produce solid knowledge and tools to facilitate learning and practice on the interaction between the natural system and human health. Four tailor-made case studies will be performed: 1) One Health effects of vector-borne diseases, 2) air pollution, 3) food contamination arising from soil and water contamination, 4) mental wellbeing linked to environmental and climate stressors, in different geographical area thanks to the large project network, that will draw universal conclusions and replicable solutions to improve the predictive capability and preparedness. The consortium will produce research, technological innovation, tailored outreach and training, and policy solutions through a cross-sectorial multidisciplinary scientific collaboration in line with the transnational character of planetary health. For these aims the project will: a) collect, organize and assure open availability of new and already existing data on climate and environmental indicators linked to One Health; b) carry out analyses on data and build innovative, inter-operable and multifunctional digital prototypes; c) produce new knowledge and tools to support One Health policies by applying social science theories and involving citizens, policymakers and stakeholders; d) offer open-access data, tools and research material to public authorities for decision making and academic research for further study.

Keywords: one health,vector borne diseases,air pollution,food safety,mental well being,climate change,planetary health
Monolithic Silicon Quantum Communication Circuitry (MOSQITO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-11-01
End date: 2026-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The advent of quantum computing and its unprecedented computational power has called the sustainability of today’s widely established encryption methods into question. Even though quantum physics addresses this emerging threat by offering quantum key distribution (QKD) at the same time, the complexity inherent to QKD systems constitutes a roadblock for their practical introduction, especially when addressing telecommunication segments that are subject to commodity-like applications. MOSQITO is an ERC Proof-of-Concept study that aims to proof the applicability of a novel monolithic silicon integration approach that is touted as a trailblazer to greatly simplify quantum communication circuits while further providing a graceful migration path towards a seamless integration of microelectronics. We will build on a recently demonstrated silicon optical power supply, which enables light emission through a quasi-direct silicon bandgap structure – thus alleviating silicon photonic integrated circuits (PIC) from the burden of complex hetero-integration of III-V materials. MOSQITO will conduct (i) the world’s first demonstration of a PIC-based QKD transmitter for BB84 polarization-encoded key exchange, where every element has been realized exclusively on a silicon basis, (ii) an evaluation of this greatly simplified QKD hardware for commodity applications such as 6G, residential access, the Industrial Internet or massively-parallel data interconnects – all of them being segments where traditional QKD implementations cannot enter the market due to cost and size concerns, and (iii) strategic clustering activities with silicon platform partners to lay inroads for refining the silicon light emitter with respect to further performance scaling and manufacturing readiness level.

Keywords: photonics,quantum communication,photonic integrated circuits,quantum key distribution
Divine Epithets in Sumerian Literary Texts and Royal Inscriptions (DESULITROI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

Epithets express gods' powers. Focussing on qualities needed for a particular ritual, they create a more effective interaction with the gods. This project will provide a catalogue of Sumerian divine epithets from a corpus of ca. 650 previously translated literary texts and royal inscriptions (ca. 2500-1600 BC). The objectives of the project are: 1) to create an online database of divine epithets found in Sumerian literary texts and royal inscriptions from the Old Sumerian to the Old Babylonian period (circa 2500–1600 BCE) which will be made available via the Leipzig University website; 2) to investigate their structure; 3) to analyse the relationship between epithets and the intentions of the texts, considering their function in narrative passages, human-divine communications and intertextuality. A relevant innovative aspect of the proposal is the interdisciplinary approach which combines the Sumerological approach, based on philology, with the methodology and theoretical frameworks developed in classical and religious studies as well as Jewish studies. Despite their role in understanding Mesopotamian religion, Sumerian divine epithets have not been systematically collected. Hence, the online database is a major desideratum in Ancient Near Eastern Studies and will fill an academic void, providing for the first time an indispensable tool for further research on Mesopotamian religion and languages and comparative religious studies. New translations and editions of Sumerian texts from the last 30 years and a better knowledge of the language now allow us to achieve a comprehensive catalogue of divine epithets. Being innovative, the project will increase the level of research excellence in European humanities. Being ground-breaking in its field, the online database of Sumerian divine epithets will contribute meaningfully to the Digital Humanities in Europe and worldwide.

Keywords: divine epithets sumerian literature mesopotamian religion sumerian language
MS-LAB: Manuscript Lives Across the United Kingdom of Great Britain and Ireland, 1860-1920. (MS-LAB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-04-30
Duration (months): 27.0
Total project cost (EUR): 292891.41
EU funding (EUR): 292891.41
Participants: 2
Project status: SIGNED

Manuscript (MS) magazines were handwritten magazines that were created for private consumption by groups of people whose contributions to the magazine made up its contents. Though research on manuscript magazines is scarce, and archival examples are scattered, they were an important part of self-made cultures circa 1860-1920. A rise in literacy, and Golden Ages of journalism, periodical literature and children's literature contributed to their popularity. Though they were often started in the domestic space, and spoke to highly localised concerns, they were circulated and had a wide readership, much like social media of today. This project, ‘MS-LAB: Manuscript Lives Across the United Kingdom of Great Britain and Ireland, 1860-1920’ will interrogate the place of MS magazines in family life and the development of literary cultivation across the four nations of the United Kingdom during the period in question. Through new archival research conducted in the four nations, and the design of a new methodology for comprehending the form and content of MS magazines, this project will produce new knowledge on this underexamined facet of shared cultural heritage. A dedicated web project hosting digitised surrogates of these manuscripts will share findings on these manuscripts with a wide public audience. During a non-academic placement with the Department of Archives and Manuscripts Collections in the National Library of Scotland, the researcher will share insights with colleagues working in the heritage industry who are typically the custodians of these unique manuscripts. The project's outcomes will pave the way for further work on this unique form in mainland Europe, as the web project and multimodal methodology can be applied to MS magazines found across other European collections.

Keywords: manuscripts,periodical studies,digital humanities,children s literature
Electrically driven DNA-origami-based machines (EDRIVE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Finland
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1999318.0
EU funding (EUR): 1999318.0
Participants: 1
Project status: SIGNED

Inspired both by Nature and the success of macroscopic machines, molecular engineers have been exploring various approaches for the realization of nanoscale artificial molecular machines (AMMs), i.e., molecular constructs capable of controlled mechanical actuation. Despite the great promise of AMMs and the tremendous progress in the field, especially on the synthesis side, multiple conceptual and technical challenges, and open questions, e.g., related to AMMs fabrication, implementation of actuation and, most important, AMMs functionality, still remain. Here, I will combine i) the DNA origami technique with its ability to construct well-defined complex three-dimensional nanostructures, and guide the assembly of functional nanoscale objects with unprecedented precision; and ii) electromechanical actuation, to build fast, remotely controlled artificial molecular machines with functionalities far beyond the state of the art. First, I will fabricate AMMs that translate external stimuli into well-defined spatial reconfiguration of metal nanostructures. I will use such AMMs to build i) active plasmonic surfaces with fast remote modulation of optical responses, and ii) plasmonics probes with single-molecule detection sensitivity. Second, I will design AMMs that can exert forces on single molecules; such AMMs will be used to fabricate i) nanoscale robotic arms, i.e., devices that can pick-up, transport and release cargo (molecules and/or nanoparticles) in multiple cycles, and ii) molecular motors, i.e., devices capable of performing useful chemical or mechanical work and driving chemical systems out of their intrinsic equilibrium. Fabrication of artificial nanoscale molecular motors has been a long-standing dream of molecular engineers. Results of this project will pave the way towards practical applications of DNA-origami-based machines and might lead to a paradigm shift in approaches to fabrication of artificial molecular machines and motors.

Keywords: artificial molecular machines,dna nanotechnology,active plasmonics,molecular motors
Gravitational wave detectors cooled with superfluid helium (GRAVITHELIUM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 3379661.0
EU funding (EUR): 3379661.0
Participants: 1
Project status: SIGNED

GRAVITHELIUM addresses the central technology challenge in third generation gravitational wave (3G GW) detectors, proposing to cool the core optics of cryogenic detectors with superfluid helium. The Einstein Telescope (ET) will be the future European 3G GW observatory, designed to observe the whole Universe. It has entered the European ESFRI Roadmap in 2021 and is supported by the major international roadmaps. ET includes new technological challenges on the verge of feasibility, particularly in the cryogenic low-frequency interferometer (ET-LF) that is crucial to exploit the full scientific potential. Cryogenic operation of the ET-LF payloads at 10 K to 20 K is indispensable to suppress the fundamental suspension thermal noise (STN) to the level of Newtonian noise, requiring new key technology developments in ultra-low noise cryogenic cooling, cryopumping and thermal shielding. GRAVITHELIUM aims for the experimental proof of a pioneering concept that proposes cryogenic payload suspensions filled with superfluid helium, as the quantum fluid He-II is the thermal reservoir that absorbs and conducts heat in the quietest possible manner. Motivated by the theoretical proof of concept, experiments on dissipative mechanisms and their STN contributions in He-II filled payload suspensions will be conducted. For this purpose, a new test facility for cryogenic Q-measurements will be build, which will also deliver data on dissipation in full-size solid-state suspensions at low temperature, needed in the GW detector community for the development of ET-LF payloads. The project further focuses on a new technology development for the attenuated and force-free supply of helium to the cryogenic payloads, cooperating with a world-leading industry partner. GRAVITHELIUM will thus achieve significant advancements in one of the key technologies to enable future frontier science with ET, providing also essential physical data for the modelling and engineering design of ET-LF payloads.

Keywords: einstein telescope,cryogenics,low frequency interferometer,superfluid helium
Dissecting transcription termination and RNA sorting in MYCN-driven tumors (TerSor)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1496660.0
EU funding (EUR): 1496660.0
Participants: 1
Project status: SIGNED

The inherent stresses arising from oncogenic transcription can be counteracted by premature termination which removes RNA polymerase II (RNAPII) from DNA and enables the degradation of aberrant nascent RNA by the nuclear exosome. When overexpressed, the MYCN oncoprotein fuels the growth of aggressive tumors by globally binding active promoters and invariably enhancing RNAPII transcription. However, I have made two key discoveries showing that the function of MYCN is not restricted to gene activation: Firstly, MYCN interacts with the exosome and prevents conflicts of RNAPII with replication forks to avert lethal DNA damage. Secondly, MYCN globally leaves promoters and directly binds nascent RNAs which are then steered to the exosome for decay. RNA bound MYCN also forms large protein complexes comprising the ARS2 transcript sorting protein, RNAPII and termination factors. These findings fundamentally expand MYCN function as they reveal that the oncoprotein exists in competing DNA- and RNA-bound states with the latter fulfilling a heretofore unknown RNA degrading role. In TerSor, we will investigate whether RNA-bound MYCN controls termination and RNA sorting processes to counteract aberrant transcription and thereby suppress DNA damage and immune recognition in neuroblastoma cells. Firstly, we will map MYCN RNA-binding domains and test the effects of RNA-binding loss in cells and neuroblastoma mouse models. Secondly, we will explore MYCN-driven regulation of termination and RNA sorting machineries. Thirdly, we will investigate how the exosome and MYCN mitigate DNA damage and the accumulation of immunogenic transcripts. Finally, we will study the structure of MYCN’s interface with exosome targeting complexes. Collectively, we will use cutting-edge approaches to profoundly further our understanding of MYCN oncogenic function by studying how the oncoprotein’s newly discovered ability to bind RNA maintains the genomic integrity and immune evasion of aggressive tumors.

Keywords: transcription termination rna binding rna sorting rna polymerase ii mycn nuclear exosome dna damage ars2
Making The Invisible Visible for Off-Highway Machinery by Conveying Extended Reality Technologies (THEIA-XR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Countries involved: Austria,Finland,Germany,Luxembourg,France,Italy
Call: eXtended Reality Technologies (RIA) (HORIZON-CL4-2022-HUMAN-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 6192686.5
EU funding (EUR): 6192686.0
Participants: 11
Project status: SIGNED

THEIA-XR (Making the invisible visible for off-highway machinery by conveying extended reality technologies) aims at improving human-machine interaction in mobile machinery by enhancing user technology fit and extending reality technologies and functionalities. The results will make the invisible visible respectively the non-perceivable perceivable to the human operator, extending the perceivable range of the operator without negatively influencing the performance of the human while controlling the machinery. The project will ensure positive impact of eXtended Reality technologies on the safety, security trustworthiness and societal aspects of the interaction between the machine, the human operator and public/non-users, and furthermore create an XR workplace that enables positive user experiences of self-efficacy and meaningfulness of work. THEIA-XR will leverage a human-centred transdisciplinary and scenario-based co-design methodology with users, stakeholders and multidisciplinary researchers as a fully integrated project team. This methodology serves to collect human requirements and to design, develop and deploy the extended reality technologies for information presentation and interaction in the off-highway domain. The targeted extended reality technologies will enhance conventional human-machine interfaces through multi-modal information and interaction technologies, deploying innovative data visualization methods, force feedback technology and acoustic information. The THEIA-XR approach for improving the human operator tasks by deploying extended reality technologies will be initially validated and tested in three uses cases in the off-highway domain, targeting snow grooming, logistics and construction scenarios, integrating real end-users, public/non-users and real-life data from dedicated industrial environments.

Keywords: extended reality,off highway machinery,transdisciplinary co design,human machine interaction,user experience
Neuromorphic computing Enabled by Heavily doped semiconductor Optics (NEHO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Germany,Belgium,France
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 2982185.0
EU funding (EUR): 2982184.75
Participants: 6
Project status: SIGNED

NEHO will develop a novel photonic integrated circuit platform that enables ultrafast and low-energy consumption neuromorphic information processes by means of a newly developed nonlinear photon-plasmon semiconductor technology at mid-infrared wavelengths (8-12 μm). NEHO vision will be achieved by unconventional use of semiconductors to optimize and control plasmonic effects that will provide the optical nonlinearity required to implement the functionalities of an artificial neuron. NEHO's optical neuron will be the building block for the realization of ultrafast optical neural networks. We will combine the flexibility of field-effect devices realized on semiconductors with the nanoscale nature of plasmonic processes so to enable the reconfigurability of the nonlinear optical coefficient at each node of the network, simply obtained by controlling DC electric potential levels. At the heart of NEHO is the idea of exploiting the rich electron dynamics of semiconductors. Doped semiconductors undergo an interesting transition from the size-quantization regime to the classical regime of plasmon oscillations. This transition region can exhibit strong nonlocal and nonlinear optical response due to a large variety of electron-electron interactions. The decrease in electron density induced on the semiconductor surface by an external bias can be used to modulate the nonlinear response strength. This unprecedented feature will be used to leverage the hardware implementation of a neural network into the development of new machine learning optimization techniques, including the optimization of the nonlinear activation function to different tasks. This extra degree of freedom will offer tremendous benefits for a large variety of machine learning applications.

Keywords: optical neural networks,hybrid photonics plasmonics,reconfigurable optical nonlinearity,semiconductor plasmonics,hydrodynamic nonlinearity