Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Parameterised Families of Strange Attractors described through Inverse Limits (PFSAIL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

This project aims to study topological and dynamical aspects of two dimensional paradigm of chaos called Hénon attractors and introduce new treatable parametrised family of strange attractors appearing in smooth dynamical systems. Despite Hénon attractors have been known to mathematicians for more than 40 years, the topology of the attractors has not been studied in details yet. The main obstacle that such a study has not been established was the lack of techniques necessary to perform it. Building on recent advances in describing parametrised families of strange attractors using inverse limits we will delve in such a detailed study and give new results on topological, dynamical and measure-theoretic features appearing in parametrised families of strange attractors. We will use methods and techniques from Topological, Smooth, Surface and Symbolic Dynamics as well as Continuum and Ergodic Theory.

Keywords: topological dynamical systems,strange attractors,parameterised families of functions,inverse limits,inhomogeneities,h non attractors,standard family of circle maps
2D Semiconductor Ferroelectric based Switchable Optoelectronics (2DSFSO)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Croatia
Call: ERA Fellowships (HORIZON-WIDERA-2023-TALENTS-02, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 161889.6
EU funding (EUR): 161889.6
Participants: 1
Project status: SIGNED

The world is foreseeing future electronics in demand of miniaturization, quantum efficiency, and low power consumption with the emergence of novel two-dimensional (2D) semiconductor materials. 2D materials' ultra-thin size, band gap engineering, and structural designing demonstrates high-performance optoelectronic devices but lacks novel materials or manipulation mechanisms to achieve low dark current, high absorption/emission efficiency, and low cost of production. Ferroelectric materials can modulate the mobility, carrier concentration, and band alignment in these 2D materials resulting in non-volatile control of photonic and optoelectronic properties. α-In2Se3, a ferroelectric semiconducting material by virtue of its peculiar crystal structure inheriting both in-plane (IP) and out-of-plane polarization (OOP) at room temperature is a game changer that manipulates the band bending and carrier transport can be non-destructive and controllable in the ferroelectric–optoelectronic hybrid systems. The 2D semiconductor ferroelectric switchable optoelectronics (2DSFSO) propose the integration of CVD-synthesized larg-area α-In2Se3 and MoS2/doped MoS2 heterostructure devices with multifunctional properties. The peculiar OOP of α-In2Se3 can switch the band alignment in the hydrid system from type II to type I exhibiting enhanced photodetection and luminescence within the same device features a switchable optoelectronic system. The cornerstones of the proposal are (a) integrating large area 2D ferroelectric and semiconductor thinfilms by epitaxial growth (b) adoption of various spectroscopic and microscopic techniques to analyze the interface physics to understand the band switching mechanism resulting in multipurpose optoelectronic devices. The large-area 2D ferroelectric platform can act as a universal platform to modulate the 2D semiconductor hybrids that can facilitate functional devices that are indispensable component for the next-generation Internet of Things system.

Keywords: cvd,ferroelectrics,thin films,heterostructures,optical characterization
A game changing platform to enlarge the pool of available organs for transplantation (Vivalyx)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2300000.0
EU funding (EUR): 2300000.0
Participants: 1
Project status: SIGNED

There are over 150,000 people on waiting lists for organ transplantation in Europe and the US today, with current transplantations only covering less than 20%, and the real need estimated at 1M organs by the WHO. Current approaches to enlarge the pool of donor organs include different organ preservation methods based on solutions and pumping systems, however these present high costs and complexity of use. Importantly, most promising systems are based on the use of blood, which is a limited, non-scalable resource that is problematic to use outside the body. Vivalyx has invented a game changing solution to the problem of organ preservation and revitalisation. This includes Omnisol, a blood substitute solution that outperforms blood 3x in terms of organ viability and function during preservation; and Flowstore, a disposable organ pumping and oxygenating system which comes at 80% lower costs for transportable body temperature organ perfusion in an easy-to-use device. Vivalyx technology enables 3-4x organ pool expansion due to the organ revitalising capabilities. Vivalyx was founded in 2022 by a group of scientists and entrepreneurs with the vision of enabling all patients on transplant waiting lists to receive the organ they need. Through the EIC project Vivalyx will bring body temperature perfusion to every patient in need of an organ, making this key technique of organ preservation scalable for the first time. Vivalyx will enter a large market growing to 4.3B€ by 2033.

Keywords: body temperature perfusion,organ preservation,organ perfusion,organ transport,kidney,liver
Revolutionizing Pneumococcal Prevention: First-of-its-Kind Universal, Cost-Effective, Nasal Spray Pneumococcal Vaccine (PNU-BERA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 18.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Abera Bioscience is pioneering a novel approach to pneumococcal prevention with its groundbreaking nasal spray vaccine, Ab-01.12. Established in 2012 as a spin-off from Stockholm University and Vrije Universiteit Amsterdam, Abera specializes in developing mucosal vaccines using its proprietary BERA platform. Ab-01.12 targets all pneumococcal serotypes, offering universal protection at a fraction of the production cost of existing vaccines. This innovation addresses a critical global health issue, with pneumococcal diseases causing over 1.5 million deaths annually, particularly affecting young children and the elderly. By advancing Ab-01.12 through clinical trials and licensing it post-Phase 2a, the company envisions becoming a world leader in developing novel mucosal vaccines for high-impact diseases, including pneumococcal infections, influenza, Chlamydia, diarrheal infections, and COVID-19. Abera has successfully secured approximately €10 million in funding, combining €4 million from prestigious grants, such as those from Vinnova and the UK Vaccine Network, with €6 million from private investments. These funds have supported extensive preclinical research, toxicology studies, and preparation for clinical trials. All toxicology studies, conducted in collaboration with Radboud University Medical Centre in the Netherlands, have concluded positively. Additionally, a GMP production slot has been secured at NorthX Biologics in Sweden, ensuring high-quality manufacturing standards. The innovative Ab-01.12 vaccine induces a robust systemic and mucosal immune response, potentially inhibiting disease transmission. It is cost-effective, priced at approximately €15 per dose, and can be produced at less than 5% of the manufacturing cost of competitors' vaccines (>€1/dose). This nasal spray vaccine simplifies logistics, being storable at room temperature, and is non-invasive, addressing needle phobia and improving compliance.

Keywords: pneumococcal,universal pneumococcal vaccine,pneumonia,nasal spray vaccine,outer membrane vesicles
Transient inactivation of hypothalamic hormone release to prevent post-traumatic stress sensitization (SECRET-DOCK)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2022-09-01
End date: 2024-02-29
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Stress is the foremost consequence of human life and became a pressing societal burden through the many sensory and societal pressures that have evolved during the past decades. Severe stress induces maladaptive changes in the brain that clinically manifest as post-traumatic stress disorder (PTSD). Despite ~4% of the population presenting PTSD, only symptomatic therapies are available. In the ’SECRET-CELLS’ ERC award, we have identified a multimodal neurocircuit that induces brain-wide sensitization to stress through the sequential recruitment of hypothalamic, midbrain and then cortical neuronal circuits. Particularly, we identified protein targets that can simultaneously affect hormone and neurotransmitter release within this circuit and whose knock-out makes mice stress resilient. Therefore, we used unbiased proteomics to select protein interactors that participate in the related signaling cascades, determined the biochemical parameters of any such interaction and the X-ray structures of the relevant protein complexes. Moreso, a high-throughput screen was established to identify inhibitors. Here, we will apply this knowledge to use interacting proteins as templates for small-molecule inhibitor discovery and hit optimization. Subsequently, we will profile the pharmacology and cytotoxicity of the candidates in vitro. Thus, we will take critical steps towards developing a ‘circuit breaker’ that can inactivate the neuronal contingents that are causal to the development of PTSD. Thereby, we will offer a fundamentally novel framework for pharmacotherapy.
MIBIREM – Toolbox for Microbiome based Remediation (MIBIREM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Innovation actions
Countries involved: Austria,Belgium,France,Germany,Italy,Netherlands
Call: Microbiomes for bio-based innovation and environmental applications (HORIZON-CL6-2021-CIRCBIO-01, 2021)
Start date: 2022-10-01
End date: 2027-03-31
Duration (months): 54.0
Total project cost (EUR): 6673083.88
EU funding (EUR): 5998173.0
Participants: 13
Project status: SIGNED

Microbiomes have high potential to improve biobased processes. For example, in soil and groundwater they can degrade organic contaminants, a process called bioremediation. In Europe about 324,000 severely contaminated sites exist, which pose a risk to humans and the environment. Conventional remediation technologies to clean them are often too expensive and technically Microbiomes have a high potential to improve processes in the bio-based industry. Like the microbiome in the gut, that supports the body in the digestion of food, microbiomes in environmental compartments like soil and groundwater can produce enzymes that can degrade organic contaminants caused by human activities. In MIBIREM we will develop a TOOLBOX that helps to better develop applications for microbiomes. The TOOLBOX includes molecular methods for a better understand and monitoring, isolation and cultivation techniques as well as quality criteria for deposition of whole microbiomes and last, but not least methods that are applied to improve specific functions of microbiomes like microbiome evolution and enrichment cultures and microcosm tests. The TOOLBOX is developed for the environmental applications of microbiomes for ‘bioremediation’. For that purpose, three use-cases were selected. In these three use-cases the degradation of organic contaminants in soil and groundwater by active microbiomes is investigated and developed. The three groups of contaminants are cyanides, hexachlorocyclohexane (HCH) and petroleum hydrocarbons (PHC). The project starts with sampling of contaminated sites to isolate microbiomes active in degradation and to gain data for the development of a prediction tool that helps guide bioremediation. Isolated microbiomes and degrading strains will be deposited and will also be improved via laboratory evolution. Finally, the performance of the isolated microbiomes will be tested based on the gained knowledge about degrading microbiomes in pilot tests under real field conditions.

Keywords: microbiome toolbox bioremediation laboratory evolution pilot tests
CO-DESIGN OF E-COMMERCE LAST-MILE DELIVERY AND RETURN OPTIONS WITH ZERO EMISSIONS (CodeZERO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Countries involved: Italy,Netherlands,Norway,Belgium
Call: Zero-emission e-commerce and freight delivery and return choices by retailers, consumers and local authorities (HORIZON-CL5-2023-D6-01, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 2996321.25
EU funding (EUR): 2996321.25
Participants: 15
Project status: SIGNED

CodeZERO is a three-year project aiming to co-create sustainable and zero-emission last-mile delivery and return solution for e-commerce that are also attractive to consumers. It is articulated in four phases: -An ANALYSIS phase which provides (1) an analysis of existing delivery and return options and an understanding of how they are shaped by the needs and constraints of all involved stakeholders; (2) an in-depth intersectional analysis of various groups of on-line consumers to understand what are the features of delivery and return options making them attractive, with the aim to identify mechanisms to incentivize behaviour changes; and (3) develops an assessment framework to measure the impacts in the environmental, economic and social domains of new solutions. -A DESIGN phase, in which CodeZERO engages in a co-design process involving retailers, transport operators, consumers and local authorities in developing (1) guidelines for retailers to raise awareness among customers; (2) a set of zero-emission and sustainable delivery and return options for retailers and transport operators; and (3) a toolset for local authorities to accelerate the transition towards sustainable solutions in last mile consignments in e-commerce. -A TEST phase running 4 pilots in 4 different European cities in Italy, Netherlands, Belgium, and Norway to test a set of sustainable solutions identified in the previous phase with the aim to prove their feasibility, to fine-tune their design and to assess their impacts from the perspective of all stakeholders. -A CONSOLIDATION phase where (1) CodeZERO outcomes are fine-tuned based on the lessons learned from real life applications, (2) requirements for up-scaling of solutions at European level are discussed (3) recommendations are formulated and (4) directions for future research are outlined. Engagement with consumers and retailers’ associations, industry stakeholders, cities and researchers contributes to shaping its results.

Keywords: zero emission co design deliveries returns last mile e commerce sustainable consumers customers retailers transport operators urban city local authority transport policymaker behaviour
Green operations with Geometric altitude, Advanced separation and Route charging Solutions (Green-GEAR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Germany,France,Belgium,Netherlands,Italy,United Kingdom
Call: ATM application-oriented Research for Aviation Green Deal (HORIZON-SESAR-2022-DES-ER-01, 2022)
Start date: 2023-09-01
End date: 2026-02-28
Duration (months): 30.0
Total project cost (EUR): 1534395.0
EU funding (EUR): 1245006.25
Participants: 8
Project status: SIGNED

Since the early days of aviation, barometric pressure measurements have been a simple and robust method for altimetry. Two drawbacks exist though: there is no direct reference to terrain, and the constant variations in pressure caused by the weather lead to increased vertical profile variability restricting capacity and flight efficiency in today’s high traffic density. One goal of Green-GEAR thus is to investigate the environmental potential of geometric altimetry enabled by satellite navigation, increasing safety and eliminating waste of airspace by removal of the transition layer and supporting more environmentally friendly climb and descent operations. With the safety case for the change of separation definition already open, not only integration of manned aviation with drones (that are already using geometric altimetry in current operations) can be addressed but Green-GEAR will also look at the potential for increasing capacity through reduced vertical separations enabled by geometric altimetry. Last but not least the project, will investigate the potential of environmentally driven route charging, with new mechanisms for charging airspace users to incentivise minimum climate impact. Route charging will reward those who avoid volumes of airspace with a high climate impact and disincentivise flight planning through high demand sectors / flight altitudes except where it optimises environmental benefit overall, while being cost neutral to airspace users and passengers on average. Added capacity in the “greener” volumes of airspace enabled by reduced vertical separations limits necessary flight plan modifications, furthering acceptance of the approach. The combination of these three topics in Green-GEAR not only raises substantial synergies and ensures a harmonised approach; it also allows to identify and solve possible interoperability issues quickly and to mature the interdependent solutions in sync, reducing time to market for any and all of them.

Keywords: satellite navigation,energy management,noise reduction,modulation of charges,algorithmic climate change functions
Hyperkähler mirror symmetry and Langlands duality (hyper-mirrors)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2028-05-31
Duration (months): 35.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

A flow of ideas from string theory has inspired spectacular progress in modern mathematical research. This intersectional phenomenon arises from the pursuit of symmetries exhibited by fundamental theories in physics and mathematics. One of these symmetries is S-duality, whose complex behaviour has remained inaccessible to our current mathematical techniques. A theoretical breakthrough came in 2006. Kapustin and Witten conjectured that S-duality gives rise to an equivalence between two types of boundary conditions - branes of type "BBB" and "BAA", conditions that come from a hyperkähler geometric structure. Their conjecture sets out a clear route to a new mathematical understanding of S-duality: construct the proposed equivalence and shine light on the underlying geometry. The action addresses this challenge using modern tools from algebraic geometry. New methods are developed within three vast fields of research: mirror symmetry, the geometric Langlands program, and wall-crossing. This broad range of ideas will be harnessed to seek powerful and novel insights into branes and their dualities. Specifically, the research objectives are: (1) Construct a categorical equivalence between BBB and BAA-branes in special cases (i.e. prove hyperkähler enhancements of homological mirror symmetry). (2) Develop a twistor theoretic approach to the geometric Langlands program, designed to encode the hyperkähler geometry of BBB and BAA-branes. (3) Apply wall-crossing to construct a class of branes with a particularly rich geometry and study their behaviour under S-duality. The implementation brings together my PhD research, wall-crossing techniques developed by the supervisor Dr. Feyzbakhsh, and spectacular recent progress on the geometric Langlands program by Gaitsgory et al. In doing so, new frontiers are sought in rapidly developing fields of research, from which myself and the academic community will benefit in the years to come.

Keywords: geometric langlands,mirror symmetry,higgs bundles,k3 surfaces,hyperk hler geometry,moduli theory,derived algebraic stacks,yang mills theories,non linear sigma models