Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Single Molecule Mechanisms of Spatio-Temporal Chromatin Architecture (ChromArch)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2021-10-31
Duration (months): 78.0
Total project cost (EUR): 1486578.0
EU funding (EUR): 1486578.0
Participants: 1
Project status: CLOSED

Chromatin packaging into the nucleus of eukaryotic cells is highly sophisticated. It not only serves to condense the genomic content into restricted space, but mainly to encode epigenetic traits ensuring temporally controlled and balanced transcription of genes and coordinated DNA replication and repair. The non-random three-dimensional chromatin architecture including looped structures between genomic control elements relies on the action of architectural proteins. However, despite increasing interest in spatio-temporal chromatin organization, mechanistic details of their contributions are not well understood. With this proposal I aim at unveiling molecular mechanisms of protein–mediated chromatin organization by in vivo single molecule tracking and quantitative super-resolution imaging of architectural proteins using reflected light sheet microscopy (RLSM). I will measure the interaction dynamics, the spatial distribution and the stoichiometry of architectural proteins throughout the nucleus and at specific chromatin loci within single cells. In complement single molecule force spectroscopy experiments using magnetic tweezers (MT), I will study mechanisms of DNA loop formation in vitro by structure-mediating proteins. Integrating these spatio-temporal and mechanical single molecule information, I will in the third sup-project measure the dynamics of relative end-to-end movements and the forces acting within a looped chromatin structure in living cells. Taken together, my experiments will greatly enhance our mechanistic understanding of three-dimensional chromatin architecture and inspire future experiments on its regulatory effects on nuclear functions and potential therapeutic utility upon controlled modification.

Keywords: live cell single molecule fluorescence microscopy,super resolution microscopy,single molecule force spectroscopy
Multinationals, Institutions and Innovation in Europe (MASSIVE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-06-01
End date: 2021-12-31
Duration (months): 79.0
Total project cost (EUR): 1276880.0
EU funding (EUR): 1276880.0
Participants: 1
Project status: CLOSED

Multinational Enterprises (MNEs) are key ‘tectonic forces’, shaping the ‘mountains’ in a far-from-flat world economic geography. In 2010, MNEs generated value added for approximately US$16 trillion accounting for more than a quarter of world GDP (UNCTAD, 2012). The progessive expansion of firms from emerging economies into multinational enterprises is unprecedented. Outflows of FDIs from developing economies reached the record level of $426 billion in 2012, corresponding to 31% of global outflows, up from 16% in 2007 (UNCTAD, 2013). However, there is no consensus in the academic literature on both the factors able to shape the long-term location decisions of MNEs and, more generally, on the ultimate impact of MNEs on their host economies. This lack of consensus reflects three fundamental gaps in the existing literature. First the omission of some fundamental determinants of MNEs investment decisions in ‘traditional’ national-level analyses. Territorial/spatial factors, MNEs heterogeneity and local institutional conditions have been often overlooked in MNEs location analyses. Second the limited attention to the broader set of impacts of MNEs in their host economies and the role of institutional factors as selective ‘filters’ for these impacts. Third the intimate inter-connection between location motives and impacts has remained unexplored in the grey areas between separate streams of literature. This research project will investigate the location strategies of MNEs and their territorial impacts addressing these three fundamental gaps in the existing literature, shedding new light on the factors shaping the economic geography of MNEs and their impacts and providing policy-makers at all levels with new tools to promote innovation, employment and economic recovery after the current economic crisis.

Keywords: multinational enterprises,institutions,innovation,regions,european union
Mechanistic basis of nucleation and spreading underlying a Polycomb-mediated epigenetic switch (EPISWITCH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 2101325.0
EU funding (EUR): 2101325.0
Participants: 1
Project status: SIGNED

Polycomb-mediated epigenetic regulation of gene expression is central to development and environmental plasticity in most eukaryotes. Polycomb Repressive Complex 2 (PRC2) is targeted to genomic sites, known as nucleation regions or Polycomb Response elements, and switches those targets to an epigenetically silenced state. But what constitutes the switching mechanism is unknown. Core epigenetic switching mechanisms have proven difficult to elucidate due to the complex molecular feedbacks involved. We will exploit a well-characterized gene system, Arabidopsis FLC, to address a central question – what are the core events that constitute a Polycomb switch? Our hypothesis is that the epigenetic switch involves stochastic conformationally-induced oligomerization, generating an ordered protein assembly of PRC2 accessory proteins and PRC2, that is then robustly distributed onto both daughter strands during DNA replication through self-templating feedback mechanisms. We will determine the local chromatin features that promote the epigenetic switch independently at each allele (i.e., in cis). We will also dissect the involvement of DNA replication in the transition from metastable to long-term epigenetic silencing, associated with the Polycomb complex spreading across the body of the locus. This interdisciplinary proposal combines molecular genetics/biology, computational biology, with structural biology, achieved through close working relationships with Prof. Martin Howard (John Innes Centre), Dr Mariann Bienz (MRC Laboratory of Molecular Biology, Cambridge) and Dr Julian Sale, (MRC Laboratory of Molecular Biology, Cambridge). This blue-sky programme aims to provide important new concepts in Polycomb-mediated epigenetic switching mechanisms, important for the whole epigenetics field.

Keywords: epigenetic switch,polycomb silencing,oligomerization,mathematical modelling
INNOVATION MANAGEMENT SERVICE SUPPORT OF EAST MARMARA NETWORK (INNOV-EM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Türkiye,Türkiye,Türkiye,Türkiye
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 50897.5
EU funding (EUR): 50897.5
Participants: 6
Project status: CLOSED

INNOV-EM Consortium composed of six partners with different type of structures like public, semi-public and private institutions and their different internal procedure struggled to achieve its targets by performing activities as projected in work plan.KOSGEB Bursa , ABİGEM DM, ULUTEK and KOU Techno park are main partners while BCCI and ECI are only supporting partners of the project proposed. The project addresses the two activities in the context of innovation support (H2020) in the services Enterprise Europe Network; “To enhance the innovation management capacity of SMEs” and “Key Account Management under SME Instrument of H2020”. The overall objective of Project is improving the innovation management capacity of promising SMEs in the region of East Marmara in Turkey. Related to the Key Account Management for beneficiaries of the SME Instrument (KAM) services, only two partners proposed targets which are KOU Tecknopark and ULUTEK since there is limited number of beneficiaries for SME Instrument, and FTI or FET-Open Projects in our region.So, consortium will focus on providing services to enhance the innovation management capacities of SMEs. Two work packages are defined for each two activities. With service of enhancing the innovation management capacity of SMEs, the consortium expect to serve to 34 SMEs with 10 days work packages and to spent 2.720 working hours. Service of Key Account Management under SME Instrument of H2020 is projected for at most 6 companies with 3,5 days work packages. If these are proceed to complete two phase of process total 168 working hours will be spent. As a result consortium proposing to mentor 40 clients in total within the scope of the project.

Keywords: innovation,sme instrument
The Complexity Revolution: Exploiting Unconventional Order in Next-Generation Materials Design (COMPLEXORDER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 3362635.0
EU funding (EUR): 3362635.0
Participants: 1
Project status: SIGNED

The fundamental objective of the research described in this proposal is to lay the foundations for understanding how structural complexity can give rise to materials properties inaccessible to structurally-simple states. The long-term vision is a paradigm shift in the way we as chemists design materials—the “Complexity Revolution”—where we move to thinking beyond the unit cell and harness unconventional order to generate emergent states with entirely novel behaviour. The key methodologies of the project are (i) exploitation of the rich structural information accessible using 3D-PDF / diffuse scattering techniques, (ii) exploration of the phase behaviour of unconventional ordered states using computational methods, and (iii) experimental/computational studies of a broad range of materials in which complexity arises from a large variety of different phenemona. In this way, the project will establish how we might controllably introduce complexity into materials by varying chemical composition and synthesis, how we might then characterise these complex states, and how we might exploit this complexity when designing next-generation materials with unprecedented electronic, catalytic, photonic, information storage, dielectric, topological, and magnetic properties.

Keywords: diffuse scattering,disorder,local structure
Mongolian Buddhist Waste and the Recalcitrant Materiality of Blessings. (RESIDUE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: CLOSED

The objective of this project is to demonstrate how the imperishable materials, that Buddhist ritual items are now predominantly made of, are transforming Buddhist praxis in the contemporary period. Although Buddhism is often considered to be a religion defined by its lack of consumerist drive, this research will highlight the ways in which Buddhist ritual practices generate consumption, waste, and excess. Utilising the ethnographic methodology of ‘following the thing’, it will trace the social lives of Mongolian Buddhist ritual items from the doubts that surround their efficacy at purchase, to their troublesome persistence after use. This project will highlight the dynamic by which Buddhist purification rituals generate ecological and spiritual pollution. Utilizing theories from Anthropology, Buddhist Studies, Discard Studies and interdisciplinary studies exploring human life in the Anthropocene, this project will generate a robust theoretical framework to demonstrate how the material properties of ritual items, rather than being incidental to their use and conception, are integral to Mongolian Buddhist beliefs and practices. This project complements, and is complemented by, the changing research trajectory of the Buddhism, Business and Believers project at The University of Copenhagen’s Center for Contemporary Buddhist Studies, as it shifts its attention from Buddhist economic entanglements to the waste that is created by Buddhist economic exchanges. By exploring the seeming non-sequitur of ‘Buddhist waste’, this research will provide new insights into the generation and treatment of waste, drawing attention to the contemporary problems that industrial-scale consumption patterns are producing in Asia and around the world. The project will support my development as an expert within this critical field, as I work to address important issues facing Mongolians and EU citizens, both in the academy and within public discourse.

Keywords: waste,buddhism,consumption,discard,excess,ritual,mongolia
Establishment of a Center of Plant Systems Biology and Biotechnology for the translation of fundamental research into sustainable bio-based technologies in Bulgaria (PlantaSYST)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Specific Grant agreement
Countries involved: Germany,Germany,Bulgaria,Bulgaria
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-06-01
End date: 2016-05-31
Duration (months): 12.0
Total project cost (EUR): 495474.5
EU funding (EUR): 494726.0
Participants: 6
Project status: CLOSED

Despite the adoption of several reform programs Bulgaria still has the lowest research and innovation index of all EU Member states. Key reasons for Bulgaria’s comparatively poor record of innovation are the insufficient investment in R&D, fluctuating labour force, the almost non-existent linkages between research and the needs of the productive sector and a lack of high-tech science and business parks. With the newly released Smart Specialization Strategy (S3) Bulgaria has an unparalleled opportunity to transform itself into a knowledge-based and R&D-led economy and to turn its research system into an engine of innovation and smart specialization. Plant systems biology, biotechnology, and healthy life have been set in the S3 as top priorities and represent research topics, which are highly addressed in Plovdiv, the biggest academic center in Southern Bulgaria and the most important agricultural region within the country. Most local research units are very productive and competitive at international level harbouring a huge academic and business potential. The goal of the project is to establish a Center of Plant Systems Biology and Biotechnology (CPSBB) in Plovdiv, which will stand at the forefront of plant sciences in Bulgaria. Building on the excellence in plant sciences and biotechnology research of Potsdam, Germany, the CPSBB will implement cutting-edge genetics, functional genomics, metabolomics and bioinformatics technologies to unravel the plant biochemical machinery and translate the scientific knowledge into the food market and industrial applications for development of value-added products with potential markets in medicine, pharmacy and cosmetics. The CPSBB will provide the missing links between academia and industry in the region and will take a leading role in educating next-generation researchers in the fields of plant systems biology and biotechnology. Thus, the CPSBB will fill the scientific and technological gaps identified in the S3 of Bulgaria.

Keywords: plant systems biology
Innate Immune Cell Swarms: Integrating and Adapting Single Cell and Population Dynamics in Inflamed and Infected Tissues (IMMUNE CELL SWARMS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2022-01-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Neutrophils are essential effector cells of the innate immune response. Intravital microscopy studies have recently changed our perspective on neutrophil tissue dynamics. They revealed swarm-like migration patterns in several models of inflammation and infection: Neutrophil populations show strikingly coordinated behavior with phases of highly directed chemotaxis and clustering at local sites of tissue damage. My previous work established that neutrophils self-amplify this swarming response by auto-signaling, which provided the first molecular basis for the collective nature of neutrophil swarms (Lämmermann et al., Nature 2013). However, we are still at the beginning of unraveling the molecular pathways behind this newly discovered phenomenon. Most importantly, we completely lack insight into the signals and mechanisms that stop neutrophil swarms in the resolution phase of an immune response. Since excess neutrophil accumulations cause deleterious tissue destruction in many inflammatory diseases, novel insights into the mechanisms, which prevent extensive swarm aggregation, might be of considerable therapeutic value. In accord with this, our proposal follows three aims: (i) dissecting the cellular and molecular mechanisms that control the resolution phase of neutrophil swarming, (ii) establishing a conceptual framework of how swarming immune cells adapt their dynamics to changing inflammatory milieus, and (iii) developing an integrated view on how neutrophil swarms are controlled by secondary waves of myeloid cell swarms. To achieve our goals, we will combine targeted mouse genetics with live cell imaging of immune cell dynamics in living tissues and the use of innovative mimics of physiological environments. Our future findings on innate immune cell swarms promise to (i) advance our knowledge on leukocyte navigation in complex inflammatory tissues and (ii) provide new avenues for the therapeutic modulation of tissue regeneration after inflammation and infection.

Keywords: intravital imaging of the immune response,neutrophils,chemoattractants,directed migration,interstitial leukocyte motility,resolution of inflammation,macrophages
Tandem Electrocatalytic Reactor for energy/Resource efficiency And process intensification (TERRA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Germany,Belgium,Netherlands,Netherlands,Denmark
Call: New adaptable catalytic reactor methodologies for Process Intensification (H2020-SPIRE-2015, 2015)
Start date: 2015-09-15
End date: 2019-09-14
Duration (months): 48.0
Total project cost (EUR): 4424785.25
EU funding (EUR): 4424784.5
Participants: 10
Project status: CLOSED

TERRA project aims to develop, from TRL 3 to 5, a tandem electrocatalytic reactor (TER) coupling an oxidation reaction to a reduction reaction, with thus the great potential advantage of i) saving resources and energy (needed to produce the oxidant and reductants for the two separate reactions), and ii) intensify the process (reduce the nr. of steps, coupling two synthesis processes and especially eliminating those to prepare the oxidation and reduction agents). The proposal address one of SPIRE Roadmap Key Actions “New ways of targeting energy input via electrochemical”. The TER unit may be used in a large field of applications, but will be developed for a specific relevant case: the synthesis of PEF (PolyEthylene Furanoate), a next generation plastic. TERRA project aims to make a step forward in this process by coupling the FDCA and MEG synthesis in a single novel TER reactor, with relevant process intensification. Between the elements of innovation of the approach are: i) operation at higher T,P than "conventional" electrochemical devices for chemical manufacturing, ii) use of noble-metal-free electrocatalysts, iii) use of novel 3D-type electrodes to increase productivity, iv) use of electrode with modulation of activity, v) possibility to utilize external bias (from unused electrical renewable energy) to enhance flexibility of operations. In addition to scale-up reactor and test under environmental relevant conditions (TRL 5), the approach in TERRA project is to address the critical elements to pass from lab-scale experimentation to industrial prototype with intensified productivity. These developments are critical for a wider use of electrochemical manufacturing in chemical and process industries.

Keywords: electrocatalysis,electrocatalytic reactor,hmf oxidation,sugar hydrogenolysis