Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innate Neuronal Circuits (INC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-11-01
End date: 2013-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Animals exhibit behavioral repertoires that are often innate and result in stereotyped sexual and social responses to their environment. Sexual behaviors represent a robust set of innate responses. Genetic studies in Drosophila strongly imply the FruM, a male-specific isoform of the fruitless gene in programming male courtship. The circuit of female behavior on the other has been largely uncharacterized. Here I propose to identify and characterize the neurons involved in female receptivity. I will follow two independent yet complementary approaches: 1) I will use a laser guided neuronal tracing procedure together with electrophysiology to follow to higher order neurons the circuit for sensing the male pheromone cisvaccenyl acetate. cisvaccenyl acetate sensing has common properties at the sensory level in males and females yet it generates different behaviors; 2) I will perform a behavioral screen of lines of flies with different subsets of neurons inhibited for their activity. Once I identify the lines that have a behavioral effect, I will characterize the anatomy, function and connectivity of the subsets of neurons marked in the selected lines. This will be facilitated by the fact these lines allow access to genetic manipulation specifically in the defined subsets of neurons. With this work I expect to contribute to a comprehensive view of the circuits for female sexual behavior. It will allow to determine how much commonality is there between the male and female brain and more importantly to identify general neuronal architectures that guide behavior.

Keywords: heath sciences,neurosciences,neurobiology,drosophila behavior,innate behavior,neural circuits,olfactory behavior,courtship behavior,cell imaging
Mechanism, Modeling and Forecasting of Landslide Displacements (FOLADIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-01-04
End date: 2013-01-03
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Landslides cause significant damage and loss of life throughout the world. There is an increase in landslide activity as a result of continued deforestation, increased construction in landslide-prone areas, and increased regional precipitation by changing climate patterns, which is a primary trigger for landslides. One of the four priorities areas in FP7 have been identified as triggering factors and forecasting, and mitigation strategies for natural hazards. The overall goal of this research is to reduce damage caused by landslides, by increasing our understanding of the mechanism of slow-moving landslides. The specific objectives are: (1) to identify the triggering factors and failure mechanisms in landslides composed mainly of (or dominated by) cohesive soils, (2) to investigate application of numerical models in slope displacement analyses and calibration of model parameters by observed deformations in well-documented case histories. (3) to establish threshold slope displacement rates that can be used in setting up alarm levels and early warning, and to improve forecasting methods that would help predict the failure time, (4) to transfer the knowledge to end-users by preparing handbooks/guidelines and training courses. The proposed research will generate (a) a large database of well-documented landslide case histories and correlations to predict certain type of movements from slopes with certain properties (material type, slope angle, etc.), (b) a numerical methodology for the evaluation of slope stability and slope deformations including validation and calibration of model parameters with the measured deformations, (c) enhanced forecasting tools for failure time prediction in landslides, (d) the range of values of threshold displacement rates for different degrees of alert levels that can be used by decision makers, (e) guidelines and manuals covering all aspects.

Keywords: soil mechanics,geotechnical engineering,landslides,natural hazards,forecasting,early warning,geological engineering
Strong-Interaction Physics and the Phase Diagram of Quantum Chromodynamics (STRONG QCD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-10-01
End date: 2013-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This proposal aims to address several outstanding problems in elementary particle and strong interaction physics receiving significant attention in experimental programs around the world. Its central goal is to further unveil the nature of hadrons and hadronic matter based on the theory of strong interactions, Quantum Chromodynamics (QCD), through combining the functional methods of non-perturbative quantum field theory in the continuum and the ab initio and first principles approach of lattice gauge theory. This involves advanced analytical studies and state-of-the-art computational methods. The main components of this proposal are: (a) to understand the most fundamental aspects of QCD, the non-perturbative nature of quark and gluon propagation and its relation to mass generation and confinement; and (b) to study the dynamics of topological objects such as monopoles and vortices and their relevance to phase transitions in theories with more than one gauge group as in the Standard Model. The results from both components will later be combined to devise advanced functional methods to explore the entire QCD phase diagram as probed in the next era of major experimental programs such as ALICE at the LHC and CBM at GSI FAIR.

Keywords: quantum field theory,nuclear physics,strong interactions,quantum chromodynamics,lattice field theory
Molecular characterization of respiratory epithelium specific Lynx3. (LYNX3)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-03-01
End date: 2014-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Tobacco use is the leading preventable cause of death in the world. Nicotine, which is the addictive ingredient of tobacco, exerts its addictive effect through nicotinic acetylcholine receptors (nAChRs) in the central nervous system (CNS). Besides mediating nicotine addiction, nAChRs have been implicated in Alzheimer’s disease, Parkinson’s disease, learning and memory, autism, anxiety disorders, depression, cell motility and cellular adhesion. Lynx1 has recently been identified as a modulator of nAChRs and it functions in nicotinic receptor mediated learning and neurodegeneration. Lynx1 is a member of Ly6 superfamily of proteins (Ly6SF), which is a large protein family that consists of proteins with a characteristic three-finger topology. Lynx family consists of ~100 kDa proteins that function mainly in the nervous system through nicotinic receptor modulation. We have recently identified Lynx2 as another modulator of nicotinic receptor activity which is involved in fear and anxiety related behavior. Lynx3 is a novel member of this family that is expressed in high levels in lung epithelial cells that are specifically important in mechanical sensation. We plan to characterize the molecular function of Lynx3 and its association to lung disease through molecular biological, physiological and behavioral techniques. Our work plan can be grouped under the following headings: 1) Characterization of Lynx3 expression in lung respiratory epithelia and other sensory epithelia. 2) Functional characterization of Lynx3 in vitro through immünoprecipitation experiments and electrophysiology. 3) Physiological analysis of Lynx3 function through targeted-deletion of Lynx3 in mouse models. Our previous work and cited literature suggest that nicotinic acetylcholine receptors are involved in lung physiology, specifically nicotinic receptor associated cellular motility and cell adhesion and Lynx3 is a potential modulator of this system.

Keywords: health sciences,lynx1,lynx2,nicotinic,lung,cilia
Neural correlates of predictive mechanisms in multisensory perception (PREDICTIVENEUROSENS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-03-01
End date: 2014-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

There are many situations in which what we see (hear) is strongly affected by what we hear (see). For instance, in the classic ventriloquism effect, the perceived location of a sound (ventriloquist&apos;s speech) is displaced towards the location of a concomitant visual event (puppet). In spite of the implausibility of the situation, our perception is resilient to our conscious knowledge that the puppet cannot speak. Conversely in noisy environments, seeing the interlocutor&apos;s face enhances the intelligibility of what is said. Thus, multisensory integration can improve, impair or create perception. How does the brain integrate information from different senses? Under which circumstances does multisensory integration benefit / impair /create perception? This project aims to clarify the brain mechanisms underlying the automatic integration of multisensory information. The major steps in this project are: (i) Psychophysical paradigms will be designed to specifically address automaticity and predictability in multisensory perception. (ii) Healthy population will be tested with combined magneto- and electro-encephalography (MEG-EEG) in order to functionally determine the neural dynamics of multisensory integration. (iii) Healthy population will be tested with functional magnetic resonance imaging (fMRI) in order to determine the precise anatomical structures underlying automatic multisensory integration. (iv) Patient populations (neglect and schizophrenic populations, in particular) will be tested using the paradigms developed in (i). An emphasis on the benefit of multisensory perception for neuro- and cognitive-rehabilitation will be made in adapting those paradigms. (v) Children will be tested using paradigms developed in (i) in order to comprehend how early in life multisensory interactions take effect and how learning skills such as reading could benefit from multisensory integration.

Keywords: health sciences,social sciences,technological sciences,humanities,natural sciences
Diffuse-Optical Monitor of Cerebral Hemodynamics after rtPA Administration in Acute Ischemic Stroke (RTPAMON)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-01-01
End date: 2013-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Ischemic stroke is the leading cause of morbidity and long term disability in Europe and United States and one of the leading causes of death. The intravenous recombinant tissue-type plasminogen activator (rtPA) is the premier drug indicated for treatment of acute ischemic stroke. Current guidelines call for its administration within the first ~three hours of the stroke onset (now being extended to 4.5 hours due to positive results of ECASS III study). However, despite its success, about 50% of patients treated with \rtpa suffer morbidity and even death. It is during this initial emergency treatment phase that a multitude of monitors are deployed in order to monitor the reperfusion (or lack thereof) of the ischemic parenchyma before widespread necrosis takes place. In this multidisciplinary project, I bring together biomedical physicists and clinical neurologists to develop a novel diffuse optical technology to continuously, non-invasively and at the bed-side monitor microvascular, local, cerebral blood oxygenation, cerebral blood volume and cerebral blood flow. Proposed technological developments will enable the use of this technology in a challenging environment such as that of the emergency care of acute ischemic stroke. We will monitor hemodynamics in penumbral regions before, during and after rtPA administration. A particular issue of interest would be the onset of recanalization and its sustainment. This pilot data will be used to assess the value of these monitors to follow the effects of recanalization (or lack thereof) on local microvascular metabolism. If successful, it may provide clinicians with the ability to individualize rtPA treatment and also to develop secondary interventions to improve the treatment outcome. This, in turn, should reduce socio-economic costs of stroke care and improve the overall health of Europeans. I believe that this project would be a key development to translate these promising technologies for clinical use.

Keywords: near-infrared spectroscopy,diffuse correlation spectroscopy,biomedical optics,stroke,ischemia,rtpa,recombinant tissue-type plasminogen activator,diagnostics,neurology,medical physics
Insights from Person-to-Person Credit Markets (P2P CREDIT MARKETS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-10-01
End date: 2013-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Person-to-person credit markets have gained popularity in recent years. Their existence as an alternative to traditional credit markets is attractive considering the recent credit crunch. Yet, our knowledge of these markets is limited. The purposes of the research program offered in this proposal are twofold: first, I will provide answer to three open questions in the regulation of financial markets and in behavioral finance. Second, by addressing these questions, an understanding of the forces shaping alternative credit markets will be gained. In order to carry out the research program, I will utilize a new rich data set from Prosper - an online person-to-person credit marketplace operated in the US. The first part of the program focuses on the effects of interest rate restrictions. I exploit a behind-the-scene change in loan origination that suddenly increased the cap faced by some borrowers, but not by others. Given the nature of the change, I use differences-in-differences analysis to explore the effects of the cap on the access to credit, the price paid by borrowers and loan repayments. The second part of the program investigates lenders’ local bias – the preference for geographic proximity. I will quantify the extent of the bias, characterize the lenders that exhibit it, and evaluate whether it is driven by advantageous information. The third part of the program will inquire into lenders’ perception of non-verified information. Portion of the information lenders observe is unverified and potentially false. I will quantify whether the importance lenders assign to non-verified information change over the time they could communicate other potentially experienced lenders through a lenders’ online forum. The results from this research will benefit policy makers who need to know how the regulation they impose affect the marketplace, and what are the sources and the extent of the allegedly behavioral phenomena of local bias and the use in non-verified information.

Keywords: person-to-person lending,consumer credit,usury laws,financial market regulation,behavioral finance,local bias,soft information
Content and Ontology based Search and Retrieval of Medical Images (COSERMI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2011-02-01
End date: 2013-01-31
Duration (months): 24.0
Total project cost (EUR): 30000.0
EU funding (EUR): 30000.0
Participants: 2
Project status: CLOSED

This reintegration project aims at combining content and context information for search and retrieval of brain magnetic resonance (MR) images from large databases. The number of digital images that need to be analyzed, processed, searched and stored at healthcare centres is exponentially increasing. To identify the underlying causes of a pathology medical experts generally benefit from similar cases. Patient search systems used for this purpose at the healthcare centres mostly use keyword-based approaches. However, combining image features (content) with patient demographic information, clinical findings and ontologies capturing disease-specific, clinical and anatomical information (context) will improve search and retrieval of medical images. Solutions in the literature generally either focus on only image content or benefit from only context information. As proposed in this grant, combining content and context knowledge for image search and retrieval will aid medical experts in finding similar cases more efficiently, and therefore will improve diagnosis and treatment efficacy of diseases whose causes and progresses are not yet fully known, and diseases with high prevalence, e.g. neurodegenerative disorders. Furthermore, such solutions may also lead into discoveries of new biomarkers. This reintegration grant proposes a novel work that combines content and context information for brain MR image search and retrieval, that processes multiple MR contrasts, that is specialised at neurology-radiology field and that can be used with disease focus.Realisation of this multidisciplinary project will result in 1.creation of powerful image search and retrieval that will aid experts in finding similar cases more efficiently, 2.improvement in diagnosis and treatment, 3.new scientific publications and patent applications, 4.contributions to European economic, social and scientific progress, and 5.long-lasting professional reintegration of the researcher.

Keywords: technological sciences,image processing,medical informatics,mining
STERILIZATION OF VARIETY OF MATERIALS, BIOMEDICAL AND FOOD PRODUCTION EQUIPMENT USING LOW THERMAL ATMOSPHERIC PRESSURE PLASMA JET COMBINED WITH ADVANCED OXIDATION PROCESSES (PLASMA STERILIZATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-04-15
End date: 2014-04-14
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The compact, portable, low-temperature gas discharge plasma device for cold sterilization of various heat-sensitive surfaces and materials is proposed. The main reactor will be atmospheric-pressure plasma jet (APPJ). The features of the sterilizer will be as follows: - ability to work at the atmospheric pressure in several gas flow, frequency and current- voltage regimes, - application of various substrate gases: oxygen, air, nitrogen, carbon dioxide, and discharge stabilizing additives (argon, helium, tetrafluoromethane, ketone, methane), - flexibility and multiapplicability due to the exchangeable sub-units of the device: various sized and shaped tips, nozzles for gas, vapor, liquid spray and foam, which could be further combined with UV lamp (Advanced Oxidation Processes, AOP). Through the combination of various decontamination techniques we hope to achieve 3D treatment effect instead only surface treatment achieves in most APPJ treatment technologies so far. Device will be used for inactivation of pathogens in plasmonic and biofilm form. Influence of the plasma treatment on the denaturing of materials (paper, plastics, fabrics, etc.) will be studied. Proposed sterilizer will be tested for preservation of solid food. Efficiency of the plasma- UV- antibacterial coatings will be tested.

Keywords: plasma sterilization,atmospheric pressure plasma,low temperature plasma,appj,multiphase reactor,aot,decontamination,treatment of biofilms,antibacterial coatings,food preservation
Cryogenic Magic Angle Spinning For Nuclear Dynamic Polarization (CRYOMAS4DNP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-01-01
End date: 2013-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

We intend to develop a new nano-characterization technique able to complement the tools currently available (AFM, TEM, XPS etc.) and to palliate the inadequacies and/or sensitivity limitations of atomic resolution techniques such as X-ray diffraction and solution NMR. Indeed, despite their success to resolve structures, they do not contribute as much to the tremendous ongoing advances in nanoscience: i.e. development of molecular memories, molecular electronics, nano-biosensors, etc. The reason relies mainly in the intrinsic nature of the samples involved (either non-crystalline or insoluble materials) and the subsequent poor detection sensitivity associated. The objective of the project is to develop a particular form of solid-state Nuclear Magnetic Resonance able to enhance the nuclear spin sensitivity by 4 to 6 orders of magnitude. To achieve this objective, we will use a high power microwave source to irradiate the unpaired electron spins (contained in optimized polarizing agents) in order to hyperpolarize surrounding nuclear spins through a mechanism called Dynamic Nuclear Polarization (DNP). The experiments will be conducted at high magnetic field, with a temperature ranging from 10 to 300 K and rotation of the sample at the magic angle in order to retain high resolution NMR conditions. The project also intends to demonstrate the pertinence of the approach for atomic structure determination of challenging nano-systems beyond reach by other techniques, e.g. functionalized nanotubes/molecular wires, paramagnetic systems (porphyrins, proteins, etc.) as well as very large non-crystalline and insoluble biomolecular systems.

Keywords: dynamic nuclear polarization,solid-state nmr,sensitivity enhancement,cryogenic magic angle spinning