Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrated Modular Power Conversion for Renewable Energy Systems with Storage (IMPRESS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: CLOSED

The research proposal addresses the challenges of optimum architecture, power production and operation for distributed renewable energy systems with storage. The proposal explores the efficient arrangement of decentralized power plants using photovoltaic panels and battery storage for a long-term increase of renewable generation. The critical issues such are the increased energy yield, minimization of cost of energy and availability will be addressed. A detailed techno-economic analysis will be performed to identify the cost effective superior distributed architecture suitable for integrated photovoltaic and battery systems. Multi-objective optimization study and validation will be performed that ensures actual optimization of energy production in the integrated environment. An integrated diagnostic method will be developed for real-time performance monitoring to improve the availability of the complex integrated energy system. Two secondment partners are identified to obtain necessary data and expertise in the field of research. The action will result in identifying an optimum solution in terms of control, operation and availability, especially for local renewable energy generation and storage. Novel algorithms for optimization for the operation and control of the modular energy sources with storage will be proposed. A real-time monitoring and diagnostic algorithm for performance monitoring, early failure detection and aging of integrated PV and battery solution will be developed. The research will provide newer insights on optimized power flow and control operation in complex interconnected distributed renewable energy sources considering the storage. Besides the technological significance and scientific value, the proposed research project is opportune and timely placed within the EU renewable energy directive and focuses on the core issue in line with the aims of EU energy research projects.

Keywords: renewable energy sources,conversion and storage,distributed photovoltaic systems,integrated renewable energy storage
Sustainable production of Cellulose-based products and additives to be used in SMEs and rural areas (CELISE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Argentina,Ecuador,Uruguay,Spain,Spain,Greece,Poland,Poland,Colombia,Norway,Latvia,Czechia,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-10-01
End date: 2025-09-30
Duration (months): 48.0
Total project cost (EUR): 621000.0
EU funding (EUR): 621000.0
Participants: 20
Project status: SIGNED

The aim of the project is to create multinational partnership between European research and innovation institutions, industry, and researcher teams in third countries in order to exchange knowledge and experience concerning cellulose-based materials using biomass residues processing in small and medium enterprises and rural areas from Europe and Latin-America. In order to fulfil the sustainability of the complete process, the new products and processes will be chosen taking into account the social (rural and/or vulnerable areas, portable pieces of equipment and educational programmes), environmental (use of natural additives and biomass residues as raw materials, removal of chemicals reactants in the processes, bioenergy) and economic (every-day products in construction and health sectors, artisan economies, engineering and mathematical tools to optimise the business models) points of view. The project enhances the development of knowledge and scientific excellence by enabling European universities and industries to establish and maintain contacts with their partners in third countries thereby facilitating access to research environments outside Europe and promoting synergies on a global scale with corresponding directly to EU & UN priorities and within some global goals of sustainable development, especially 7, 9 and 11.

Keywords: cellulose,nanocellulose,fibres,adhesives,residues,biorefinery,modelling and simulation
ERA-NET: Aligning national/regional translational cancer research programmes and activities (TRANSCAN-2)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: ERA-NET Cofund
Partnership: TRANSCAN-2 (ERA-NET)
Countries involved: Spain,Spain,Estonia,Italy,Austria,Germany,Italy,Israel,Germany,Italy,Italy,Taiwan, Province of China,Norway,Greece,Poland,Slovenia,Türkiye,Belgium,Hungary,Slovakia,Latvia,France,France,Netherlands,Netherlands,Portugal
Call: ERA-NET: Aligning national/regional translational cancer research programmes and activities (H2020-HCO-2014, 2014)
Start date: 2015-01-01
End date: 2021-06-30
Duration (months): 78.0
Total project cost (EUR): 22568750.0
EU funding (EUR): 6672187.0
Participants: 34
Project status: CLOSED

Cancer is a worldwide health burden and represents a major public health challenge in Europe. It is responsible for 25% of all deaths, being the second most common cause of death after cardio-vascular diseases and the main cause of mortality among people aged 45–64. Today, an estimated 9 million individuals in Europe live with cancer (Globocan 2008, http://globocan.iarc.fr/). Cancer became a chronic disease which contributed substantially to the growth of medical expenditures and constitutes a major socio-economic challenge for Europe as well as globally. A rapid and effective bidirectional transfer of relevant cancer research findings between bench and bedside would play a pivotal role in addressing top-priority needs at the EU level to reduce incidence and mortality of malignancies and to improve the quality of life of cancer patients. The proposed ERA-NET Cofund TRANSCAN-2, in continuity with the preceding and ongoing TRANSCAN ERA-NET, aims at linking translational cancer research funding programmes in 15 Member States, 3 Associated Countries, and a third country. By concentrating transnational resources, TRANSCAN-2 will provide a critical financial and scientific mass for tackling large-scale problems, relevant for improving translational cancer research globally. A co-funded joint transnational call (JTC) will be launched focusing on the topic “Intratumour heterogeneity in resistance to therapy and recurrence” followed by three additional JTCs that will be implemented in a frame of multinational translational cancer research programmes. In addition, strategies will be developed for the enlargement of the network, for improvement of coordination and for an efficient communication and dissemination of the results of the consortium as well as of the research projects funded through the JTCs. The monitoring of the projects funded through the JTCs and the critical assessment of the performance of TRANSCAN-2, based on key indicators, will be also realised.

Keywords: translational cancer research,coordination of national and regional programmes,transcan co funded transnational calls
Synthetic Mimicry of Cellular Polarisation (POLAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Biological self-organisation through spontaneous symmetry breaking is essential for the emergence and maintenance of life. Cell polarity, where an asymmetric distribution of molecules is achieved within a cellular compartment, is one of the simplest and most studied examples. However, due to the diversity and complexity of nature, and despite the many known pathways and theoretical models, the fundamental mechanisms are still poorly understood. I propose a ‘bottom-up’ synthetic biology approach to build a synthetic system capable of mimicking cellular polarisation in an artificial compartment. Modular fusion proteins will be engineered from small, well-characterised protein domains and reconstituted into artificial membrane-bound compartments such as Giant Unilamellar Vesicles (GUVs) and microfluidic water-in-oil droplets. The self-organisation of these proteins through autocatalytic membrane-recruitment will be monitored with a variety of fluorescence microscopy techniques. In doing so, I will create a minimal, defined system in which to test general principles of biological self-organisation, abstracted from the ‘noise’ of natural systems. Further, orthogonal synthetic systems could be introduced into living organisms to control morphology and other functions, or be used to build higher-level mimics of life such as proto-cells.

Keywords: cell polarity,self organisation,proto cells,bottom up synthetic biology
Proton conduction in structured water (PROWAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-03-31
Duration (months): 66.0
Total project cost (EUR): 2495000.0
EU funding (EUR): 2495000.0
Participants: 1
Project status: CLOSED

In recent years water near surfaces and solutes has been observed to be differently structured and to show slower reorientation and hydrogen-bond dynamics than in bulk. Aqueous proton transfer is a process that strongly relies on the structure and dynamics of the hydrogen-bond network of liquid water and that often occurs near surfaces. Examples are thylakoid and mitochondrial membranes and the nanochannels of transmembrane proteins and fuel cells. An important but experimentally largely unexplored area of research is how the rate and mechanism of aqueous proton transfer change due to the surface-induced structuring of the water medium. Theoretical work showed that the structuring and nano-confinement of water can have a strong effect on the proton mobility. Recently, experimental tech- niques have been developed that are capable of probing the structural dynamics of water molecules and proton-hydration structures near surfaces. These techniques include heterodyne detected sum-frequency generation (HD-SFG) and two-dimensional HD-SFG (2D-HD-VSFG). I propose to use these and other advanced spectroscopic techniques to study the rate and molecular mech- anisms of proton transfer through structured aqueous media. These systems include aqueous solutions of different solutes, water near extended surfaces like graphene and electrically switchable monolayers, and the aqueous nanochannels of metal-organic frameworks. These studies will provide a fundamen- tal understanding of the molecular mechanisms of aqueous proton transfer in natural and man-made (bio)molecular systems, and can lead to the development of new proton-conducting membranes and nanochannels with applications in fuel cells. The obtained knowledge can also lead to new strategies to control proton mobility, e.g. by electrical switching of the properties of the water network at surfaces and in nanochannels, i.e. to field-effect proton transistors.
Addressing metalloenzymes for clean energy production with advanced embedding schemes and quantum mechanical methods (MetEmbed)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-08-01
End date: 2021-01-30
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

The proposed project aims to develop and apply quantum mechanical (QM) methods targeted at metalloenzymes, for which the methods in use today often fail. The failures are caused by inaccuracies in either 1) the underlying protein structures, 2) the employed QM method or 3) the embedding method that describes electrostatic interactions between the protein environment and the active site (i.e. metal and its nearest ligands). The MetEmbed project addresses 1), 2) and 3) with hydrogenases and polysaccharide monooxygenases (PMOs) as target enzymes. Hydrogenases mediate the reversible conversion of dihydrogen into hydride ions and protons, while PMOs have shown great potential for biofuel production. The overall objective is to investigate the reaction and spin-state energetics for key intermediates in the two proteins' catalytic cycles. To ensure that the underlying structures are accurate, extensive molecular dynamics (MD) simulations with tailored force fields and QM/MM methods will be employed. The adequacy of the QM methods will be ensured by using accurate, multireference QM methods that are known to be well-suited for transition metal systems. Two new multireference QM methods will be applied, namely a multiconfigurational density functional theory hybrid and the density matrix renormalization group method. These methods have high potential for metalloenzymes, but have until now only found little use in this area. To address the effect of the protein electrostatics, an accurate embedding scheme that, contrary to most QM/MM methods, includes the polarization of the environment will be used. The combination of 1) accurate structures, 2) accurate QM methods and 3) polarizable embedding schemes is unprecedented for metalloenzymes. The MetEmbed project will thus predict energetics with a new level of confidence for two systems with high potential in the areas of energy efficiency and low-carbon energy production; both central parts of the HORIZON2020 program.

Keywords: mm methods,metalloenzymes,hydrogenases,polysaccharide monooxygenase
Quantum Interference Enhanced Thermoelectricity (QuIET)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,Switzerland,Switzerland,Netherlands,United Kingdom,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2022-07-31
Duration (months): 54.0
Total project cost (EUR): 3118272.5
EU funding (EUR): 3118272.5
Participants: 7
Project status: CLOSED

Our vision is to demonstrate that room-temperature quantum interference effects, measured recently in single molecules, can be exploited in massively-parallel arrays of molecules and used to design ultra-thin-film thermoelectric devices with unprecedented ability to convert waste heat to electricity using the Seebeck effect and to cool at the nanoscale via the Peltier effect. Although the dream of high-performance thermoelectric devices has been discussed for many years, evidence of the room-temperature quantum interference effects needed to realise this dream was achieved experimentally only recently. Building on these indirect demonstrations of quantum interference in single molecules using non-scalable set ups, we anticipate that the next breakthrough will be the implementation of QI functionality these intechnologically-relevant platforms. We shall design molecules with built-in quantum interference functionality, which can be used to engineer the properties of ultra-thin molecular films. Molecules will be designed with robust anchors to metallic and carbon-based nano-gap electrodes, which enhance electron transport and eliminate unwanted phonons.This contacting strategy is scalable from a single junction, with the potential to be replicated billions of times on a single substrate. The ability to exploit quantum interference at room temperature will enable new thermoelectric materials and devices with the ability to scavenge energy with unprecedented efficiency. QuIET is a highly interdisciplinary project that brings together internationally leading scientists from four different countries with proven expertise on synthesis, transport measurements and theoretical modelling.

Keywords: thermoelectricity,molecular electronics,quantum transport,quantum interference,molecular junctions,self assembled monolayers
D-FENCE: Deceptive Monitored Environments for Cybersecurity in Enterprises (D-FENCE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The ineffectiveness of current cybersecurity solutions is alarming: 97% of entities are vulnerable to the more and more sophisticated attacks of hackers and the reported incidences have multiplied its number by 18 from 2009 to 2015. This is causing massive annual losses of approx. €38Bn/year only in Europe, with an average damage of €9.5M per company attacked. The rising trend on the Internet of Things, expected to bring 50 Bn connected devices by 2020, will multiply by orders of magnitude the risks of cybercrime and so the potential damages. Aiming to tackle this challenge, we present D-FENCE, an advanced cybersecurity solution that applies Cyber Deception to ‘cheat the hackers’. D-FENCE creates lures (credentials, HTML tags, cookies…) and distributes them across the real production systems. These lures point to our decoys, i.e. false endpoints (PCs, servers…) that mimic real assets. When attackers try to access the decoys (and they will do), an alarm is immediately triggered, so it is possibly to rapidly detect, monitor, analyse and counteract any attack. Meanwhile, the real assets are safe from the attacker, who is tangled in our deceptive virtual environment. According to our preliminary experiences, D-FENCE enables 70% more effective and 95% faster detection of attacks compared to existing cybersecurity solutions, meaning potential savings of billions € per year. We, Cybertrap GmbH, are an Austrian start-up devoted to create cybersecurity solutions. The D-FENCE Project is the natural continuation of our previous achievements and brings an enormous opportunity not only for our company but also for the European and global economy. The enhanced prevention, detection and counteraction capabilities provided by D-FENCE will enable companies saving hundreds of thousands to millions € per entity and billions € at EU level. For our company, D-FENCE’s commercialisation will have as well remarkable impact: +€13.3M revenues and at least 30 new job positions by 2023.

Keywords: cybersecurity,cyberdeception,cyberdefence,deceptive technology,protection,critical infrastructure,cyberattacks,hacker,managed service,threat
Enabling Large-Scale GMP-ready Peptide Production with a new, reliable and cost-efficient Bioprocess (NUMA-SCALE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-11-01
End date: 2019-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Peptides, competent biomolecules, have gained increased interest as innovative therapeutics in the pharmaceutical market due to being highly selective, efficacious, relatively safe and well tolerated. Peptide-based drugs have been successfully applied in treating certain human diseases. Well-known example includes insulin, which compromises a peptide that is built to block and control the metabolism of sugar. With the increase of approved peptide-based drugs, the production of peptides will escalate. Yet, peptide manufacture companies (for peptide-based drugs), which need to be compliant with good manufacturing practices (GMP), face a several challenges, the main ones being high production costs on downstream processes (due to the use of high raw material amounts) and bad scalability. Numaferm is a German company founded in 2015 with the mission of making peptides economical for pharmaceutical markets. To tackle current challenges, we have developed two (patented) innovative technologies (NUMAtag and NUMAswitch) whose unique features are not offered by the alternatives in the market for peptide manufacture: cost-efficient production (50x reduction of manufacturing costs, under GMP); environmentally friendly process (reduced carbon foot print by >90%); scalable production (peptide scalability by ton scale with no peptide length limitation), thus enabling a high efficiency upstream and downstream process for peptide manufacture. Through the NUMA-SCALE project we aim to upscale our production and extend our commercial capabilities (by making our processes ready for tech-transfer into GMP facilities of Contract Manufacture Organizations) thus allowing us to seize more business opportunities. This project will have a massive positive impact to Numaferm – will boost our revenues (+€14.8M by 2023), employability (creation of 15 new jobs) and generate new IP, allowing us to continuously venture new markets with our technology.

Keywords: bioprocess,upstream,downstream,peptide manufacture,recombinant platform,pharmaceutical market,cosmetic market,antimicrobials,cost reduction,scalability,biomolecule