Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
3D Flexible Probe for Deep Brain Stimulation and Recording (BRAIN TOUCH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-08-01
End date: 2010-07-31
Duration (months): 24.0
Total project cost (EUR): 157855.67
EU funding (EUR): 157855.67
Participants: 1
Project status: CLOSED

The objective of the present proposal is to develop a new generation of flexible Deep Brain Stimulation and Recording (DBSR) probe that could significantly improve and standardize the deep brain stimulation therapies by offering the possibility of multiple site, three dimensional distributed and adaptive neural stimulation (feedback through simultaneous neural signal recording). Today, there is no available neuro-probe that offers all these functions. Even if significant advances had been made both in silicon and in polymer based probes taking advantage of the high throughput microfabrication techniques offered by the integrated circuit (IC) industry, when it comes to humans, all these devices can be used exclusively for sensing and stimulation of cortex regions, spinal cord and peripheral nerve fibers, leaving available for the DBS applications only the classic micro-wire technology. We propose a manufacture concept based on silicon wafer thinning and bonding on flexible substrates that could remedy this unbalanced situation, by giving to the DBS field access to all the technological advances made in the IC industry. The research will require combined efforts in the fields of microelectronics, polymer material, neurobiology, neurophysiology and neurosurgery to be merged together in order to enable progress beyond the state of the art devices available today. The work will be conducted in the Bio-Electronic Systems group of IMEC (Leuven, Belgium) in close collaboration with the Experimental Neurosurgery and Neuroanatomy Laboratory of the Katholieke Universitiet Leuven (K.U.Leuven). Its successful completion would provide novel scientific and technological concepts for the improvement and standardization of the DBS therapies, with a direct economic outcome: a dramatic decrease of the therapy cost together with a significant increase in accessibility.
Molecular dissection of factors controlling flux through pathways (REGULATION OF FLUX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2009-04-01
End date: 2011-03-31
Duration (months): 24.0
Total project cost (EUR): 200222.68
EU funding (EUR): 200222.68
Participants: 1
Project status: CLOSED

Plants produce a spectacular number of bioactive natural products which are essential for plant disease resistance, plant growth and development, and which have great commercial potential for human use as e.g. biomedicines. Current engineering approaches by overexpression of biosynthetic genes often results in only low levels of the desired product. This most likely reflects the complexity of the regulatory networks controlling metabolic flux through biosynthetic pathways. An important prerequisite for fully exploiting the potential of metabolic engineering of natural products is to understand the underlying regulatory and homeostatic mechanisms at the molecular level. Glucosinolates are natural products of the model plant Arabidopsis. The availability of highly advanced bioinformatics and molecular tools combined with extensive mutant collections in Arabidopsis makes the glucosinolate pathway an excellent model system for studying regulation of metabolic flux. Recent advances in glucosinolate research have identified the first transcription factors and shown that flux through the pathway is controlled by not only regulatory proteins but also the last biosynthetic gene in the pathway. State-of-the-art techniques within integrative bioinformatics, protein-protein interaction, transactivation assays, differential transcript and metabolite profiling will be applied to identify novel interacting regulatory partners and to unravel the molecular mechanism by which the biosynthetic gene controls flux. The project will develop excellent scientific and leadership competences at a high level for a talented young European scientist to build an independent future career in science. The proposed project may provide future biotechnological solutions for engineering the production of natural products into plants to improve food quality and disease resistance, and to use plants as green factories producing high-value products like pharmaceuticals.

Keywords: metabolic engineering,natural products,glucosinolate biosynthesis,regulatory networks,flux,integrative bioinformatics,global microarray analysis,differential metabolomics,protein interaction
Biosynthetic studies of nudicaulins in laser-microdissected petal cell of Papaver nudicaule by the use of NMR spectroscopy and hyphenated technique LC-NMR. (BIOSYN-NUDICAUL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-05-01
End date: 2010-04-30
Duration (months): 24.0
Total project cost (EUR): 159261.86
EU funding (EUR): 159261.86
Participants: 1
Project status: CLOSED

Nudicaulins is a group of alkaloids compounds present in petals of Papaver nudicaule (Iceland poppy) flower. That class of compounds represents a further group of coloured alkaloids and their accumulation in petals could enhance the attraction of flowers for insects. The elusive structure of these pigments, responsible about the dark yellowed petal variety of Papaver nudicaule, attracts our interest about the biosynthetic formation which is still unknown. Moreover there is a fascinating debate about the formation of these unique compounds if derived by Diels Alder or ionic (4+2) cycloaddition of indole. Through those pigments, seem to occur exclusively in petals of flower and the final biosynthetic step is expected to be performed very likely in petals as well. It is not clear whether the precursors are preformed in other plant parts, nor if there are special storage cell in petals. Biosynthetic studies consisted either of injection of labelled precursors to plant material at a reasonable time before their derived isotopomers identification, either to use of a non invasive application such as the illumination of plant for a few hours in atmosphere of synthetic air enriched with 13CO2, resulted to isotopologues production. The collected plant material is going to be treated with laser-assisted microdissection in order to obtained the important for our research single plant cells or specific cell population containing the under study compounds, succeeded an important enrichment of the sample. Usually, the labeled sample material is analyzed by liquid chromatography and isolated compounds identified by Nuclear Magnetic Resonance spectroscopy. Moreover in present work we are going to analyze the microdissected plant material by the newly established hyphenated technique LC-NMR, and develop the analysis of results from detection of isotopomers or isotopologues with direct or indirect methods.

Keywords: natural sciences,plant biochemistry,chemical ecology,alkaloids,biosynthesis,nmr spectroscopy
Dealing with Imperfect Information in Systemic Concerns of Software Product Line Requirements (DISCS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-09-01
End date: 2010-08-31
Duration (months): 24.0
Total project cost (EUR): 168823.92
EU funding (EUR): 168823.92
Participants: 1
Project status: CLOSED

Software systems are becoming an integral part of every part of our life and as a result more software systems are produced than ever before. To manage the complexity and improve the efficiency of producing large varieties of software products, software product lines have received increasing support and attention. In a product line, the production of a variety of products is simplified by capturing the common properties of the products in reusable building blocks. Specific products are realized by extending the functionality of the blocks using sophisticated variation mechanisms. While product lines offer an effective approach to handle product families, their design is a very complex activity, which requires a considerable amount of information. Accurate information on the variance in products is required for the product line to be effective. While it is difficult enough to acquire such information under ideal circumstances, in practice software architects are faced with partial and ambiguous descriptions of the desired functionality and variability. This type of information is referred to as imperfect information. We address this problem by coming to an analysis approach and supporting tool that offer decision support during the development of product lines. The approach and tool assist the software developer in identifying imperfection in requirements and considering its impact on product line design. To achieve this objective, we utilize a multi-disciplinary approach combining techniques from corpus linguistics, fuzzy logic, aspect-oriented requirement analysis and combinatorial optimization. The research project offers excellent potential to further the excellence of the European Union in product line research and imperfect information in software design. With the state-of-the-art research topic, a comprehensive training program and the facilities offered by the host, the project offers outstanding potential for the development of the fellow’s career.

Keywords: technological sciences,software product lines,imperfect information,requirements engineering,decision support
A combined approach to smart imaging agents- using heterometallic lanthanide complexes as diagnostics (MRLI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-04-01
End date: 2009-12-31
Duration (months): 21.0
Total project cost (EUR): 177740.04
EU funding (EUR): 177740.04
Participants: 1
Project status: CLOSED

This proposal aims to develop new contrast agents, derived from heterobinuclear lanthanide complexes, for use in imaging. These will combine the interesting properties of gadolinium complexes used in magnetic resonance imaging with those of luminescent lanthanide ions used in time-resolved micrscopy and assay applications. Our aims are fourfold, namely: To develop synthetic strategies which allow us to prepare heterometallic complexes suitable for multimodal imaging, using multi-component reactions or approaches involving diazo coupling to access these complexes; To develop methods by which nucleotide or PNA recognition domains are used to facilitate rapid transport of imaging components and programmed self-assembly of the multimodal imaging edifice at the target site; To develop switchable multi-modal agents, whose properties are altered by chemical or electrochemical change; and To prepare and study a range of multimodal imaging agents that can be targeted to cell surface receptors, and which have sufficiently high relaxivity to provide meaningful MRI contrast at low concentrations.

Keywords: inorganic chemistry,organic chemistry,diagnostics
Coordinated Observational and Numerical Studies of InterStellar Tracers (CONSIST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2008-10-01
End date: 2010-09-30
Duration (months): 24.0
Total project cost (EUR): 170709.11
EU funding (EUR): 170709.11
Participants: 1
Project status: CLOSED

The dynamical and chemical evolution of diffuse interstellar gas is a key process in the development of structure in the Universe, leading to the subsequent production of stars, planets and ultimately, life itself. The goals of this research programme are to bring together the most comprehensive, detailed astrophysical data of the neutral phases of the interstellar medium in our Galaxy and the most complete current model of their dynamical and evolutionary relationship. Our observational data are from new, forefront international observational initiatives at multiple wavelengths, while our numerical magnetohydrodynamic models of our entire Galaxy uniquely include spiral structure, multi-temperature and multi-phase capability through the addition of CO and H2 formation from the atomic gas. The key advances enabled by the numerical models are the ability to visualize and quantify the time evolution of important ISM structures (e.g. molecular clouds) and reveal the observationally invisible molecular hydrogen component. The models provide context for understanding the observational signatures of particular stages of evolution (e.g. HI self-absorption clouds, infrared dark clouds) that are of current great scientific interest. The detailed observational data in turn allow tests of the spiral shock model of molecular cloud formation (thought to be the dominant evolutionary path) in terms of (e.g.) the kinematic structure of CO and HI emission, the amount of HISA produced for given model parameters, the reproduction of the molecular cloud size-linewidth relation, and other measures. There are many avenues for the development of this core research, both observationally and theroretically, that will extend beyond the nominal duration of the project. The models and data together will form the basis of a virtuous cycle, wherein refinements and extensions to the models are imposed by the data.

Keywords: physical sciences,interstellar medium,hydrogen,dust,observations,numerical simulations
Reagentless Electrochemical & Fluorescent Biosensor Formats for Detection of Coeliac Disease Toxic Gluten (Gliadins and Glutenins) in Raw and Processed Foodstuffs (GLUSENS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-07-01
End date: 2008-12-31
Duration (months): 6.0
Total project cost (EUR): 209385.57
EU funding (EUR): 209385.57
Participants: 1
Project status: CLOSED

Coeliac disease is an inflammatory disease of the upper small intestine that affects as much as 1% of the European population and results from gluten ingestion in genetically susceptible individuals. The only treatment for CD is a strict gluten-free diet, with the longer the individual fails to adhere to this diet, the greater the chance of developing malnutrition and other complications. Thus, the existence of reliable gluten free food is crucial to the well-being of the population. Current assays available for detection of gluten in food suffer from many drawbacks. Firstly, there appears increasing knowledge as to the toxicity of particular gluten proteins. Secondly, there is no existing protocol that has been demonstrated to quantitatively extract gluten from both raw and processed foodstuffs and assays based on the use of antibodies are incompatible with the reducing reagents. Fourthly, assays typically used for gluten detection exploit indirect sandwich assays, typically requiring 6-8 hours to complete. Here we propose to address each of the challenges to develop reagentless biosensors for in-situ detection of gluten in foodstuffs by using aptamers. Aptamers are getting more and more attention in biosensor area especially because of their superior properties over antibodies. Aptamers will be selected against these identified gluten toxic sequences in buffer conditions akin to that required for gluten extraction and are thus unaffected by the reducing agents present (contrary to the case of antibodies). Furthermore, aptamers lend themselves to highly flexible assay formats not attainable using antibodies. In the work proposed here, we intend to take special extraction protocol and selected aptamers and exploit them for use in various reagentless aptasensor formats (e.g. fluorescent-electrochemical displacement, molecular aptamer beacons) that will allow the rapid, inexpensive, accurate and facile detection of gluten in foodstuffs.

Keywords: technological sciences,health sciences,aptamers,biosensor,celiac disease,gluten,food toxicity,molecular beacons,electochemical detection,fluorescent detection,sele
Parameter Optimisation of a terrestrial biosphere model to Link processes to Inter annual variability of Carbon fluxes in European forest Ecosystems (POLICE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-06-23
End date: 2010-06-22
Duration (months): 24.0
Total project cost (EUR): 162301.94
EU funding (EUR): 162301.94
Participants: 1
Project status: CLOSED

Inter annual variations of net ecosystem carbon exchange (NEE), driven by weather and climate, are known to contribute to variation in the annual growth rate of atmospheric CO2 globally, but little is known about the underlying processes in each region. Better ability to predict future atmospheric CO2 levels and climate change should thus be gained by understanding the current inter annual variation in the biotic response to environmental forcing. In this context, I propose to assess, using a state of the art data assimilation approach, the impact of extreme climate spells, such as the summer 2003, versus the one of “normal” year-to-year climate variations on the processes which control the European carbon balance. This knowledge will be propagated into better future projections of the European carbon balance. Overall, the scientific objectives of the project will be primarily investigated using an parameter optimisation approach. Estimation of the process-based ecosystem parameters using radiation, sensible heat, latent heat, and CO2 exchanges at several ecosystem sites (forest) will help to improve the simulation of inter annual variations in terrestrial CO2 fluxes and to assess the potential of the ORCHIDEE model. The overall objectives of this proposal are threefold: (1) Optimisation of all critical parameters of ORCHIDEE and assessment of the limits of this process-based model to simulate eddy covariance measurements. (2) Identification of drivers and processes determining inter annual variations of forest carbon fluxes. (3) Improved model future projections of Europe’s carbon balance, with uncertainty estimates, using the optimized parameters.

Keywords: natural sciences,ecosystem models,inter annual variability,forests,european carbon balance
Analysis of Low-cost Original Holographic Antenna: Theoretical OveRvIew, NOtes, StudY, DesigN, and EasY Implementation (ALOHA TORINO-SYDNEY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2007-4-1-IOF, 2007)
Start date: 2009-07-01
End date: 2012-06-30
Duration (months): 36.0
Total project cost (EUR): 327125.49
EU funding (EUR): 327125.49
Participants: 1
Project status: CLOSED

The proposal aimed to the theoretical investigation, the numerical study and the experimental characterization of holographic antennas (HA) based on microstrip technology. Studies of holograms have been started at optical frequencies to obtain virtual images as a result of interference of two polarized electromagnetic waves. The first applications of holograms at microwave frequency are date back to 70’, but nowadays the topic is at the edge of the interest of the scientific community. There are various research groups studying antennas based on this principle, since holographic surfaces offer new potentialities in this field. HA indicates a group of antennas in which the radiating aperture is formed by a conductive metallic like pattern on a surface-wave carrying grounded (multi)layer dielectric substrate. The hologram is obtained by recording the resulting interference between two polarized electromagnetic waves at the air-substrate interface. Exciting the hologram with only one of these two waves the second one is generated. The hologram is view as variable surface impedance: its synthesis is realized by width modulated microstrip lines. The periodic arrangement of such structures allows the generation of a substrate that supports slow waves, mandatory for the coupling between the surface and space waves. The control of the phase velocity, i.e. the surface impedance, is achieved by adequately vary the width of a microstrip line inside the unit cells. This method has been recently submitted to be patented. Antennas based on this principle present various advantages. The main important one is the polarization purity of the radiated field. The absence of the feeder in the front of the antenna eliminates the blockage; hence a higher gain can be achieved. The proposed low cost microstrip technology is widely employed in aero spatial application as well, because the reduce dimensions of the antennas and the possibility to build conformal configurations.

Keywords: holography,antenna,metamaterials,electromagnetic band-gap,electromagnetic field,numerical techniques