Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
CANCER PREVENTION VS CANCER TREATMENT: THE RARE TUMOUR RISK SYNDROMES BATTLE (PREVENTABLE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: Research and Innovation actions
Countries involved: Portugal,United Kingdom,Spain,France,Netherlands,Norway,Germany,Belgium,Sweden
Call: Better financing models for health systems (HORIZON-HLTH-2022-CARE-08, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 4686000.0
EU funding (EUR): 4642249.75
Participants: 16
Project status: SIGNED

Rare tumour risk syndromes (RTRS) are rare diseases, affecting 5 per 10.000 people or less and caused by heritable genetic variants. In RTRS, the lifetime risk to develop various cancers can be as high as 100%, and patients have a 50% chance of transmitting the disease to their offspring. When undiagnosed or not surveilled, many asymptomatic RTRS patients develop particularly aggressive cancers, leading to premature death, severely impacting theirs and their families’ health and wellbeing. Cancers in RTRS can be prevented and survival rates maximized if asymptomatic RTRS patients are intensively surveilled for RTRS-prone organs, cancer-prone organs are surgically removed prior to disease development, or very small cancerous or pre-cancerous lesions are removed or treated. RTRS are therefore a unique and tangible context for cancer prevention, early diagnosis and treatment with curative intent. However, risk-reduction strategies are not always prioritized in genetically diagnosed and asymptomatic RTRS patients, and most healthcare systems keep on opting for treatment of clinically expressed cancer. This occurs despite the knowledge that hospitalization has the highest weight on advanced cancer healthcare spending. It is therefore urgent to demonstrate the cost-benefit of the application of preventive measures in RTRS syndromes. The ambition of the PREVENTABLE project is to merge specialized clinical knowledge on RTRS pathways of care, real-life clinical data from RTRS patients and experiences from professionals and patients, with health economic models and social sciences approaches to estimate the cost-benefit of risk-reduction interventions in RTRS and delineate guidelines for its communication among and within clinical teams and RTRS patients. PREVENTABLE project results will be delivered to a diversity of stakeholders, including policy-makers, in order to promote the implementation of cost-effective RTRS patient-centered care in Europe.

Keywords: rare tumour risk syndromes,genetic predisposition,pathways of care,risk reduction,cost benefit studies,behavioural analysis,cancer prevention,european reference networks,genturis
Flying Repair Drone for Wind Turbines Blades (flying factory)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-03-01
End date: 2024-10-31
Duration (months): 20.0
Total project cost (EUR): 1791750.0
EU funding (EUR): 1254225.0
Participants: 1
Project status: CLOSED

All existing repair solutions use a vertically positioned blade due to rope-hanging robots or workers. The proposed solution for fast repairs of leading edge erosion is based on a first-ever approach, where a drone lands on a horisontally positioned blade. This approach eliminates both the time-consuming rope-access requirement and associated fall risks from manual repairs entirely. Being able to apply the new generation of leading edge protection, will catapult the present state-of-the-art of blade protection, enabling upgraded blades to generate energy with 10% higher output and efficiency. In addition, the application of leading edge protection by our technology, will yield an automatic, fast, uniform, controlled, and documented quality, which has been well received by key market partners in demonstrations. Our drone is targeted to repair at higher wind speeds than is realistic with existing market solutions, and is well-suited for both existing and future wind turbines.

Keywords: renewable energy sources,automation
Controlling Gene Expression with Synthetic Cell-Penetrating Transcription Factors (SynTra)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 1851328.0
EU funding (EUR): 1851328.0
Participants: 1
Project status: SIGNED

The overarching goal of SynTra is the engineering of synthetic transcription factors (STFs) that can enter cells and activate or deactivate specific genes. Traditional drugs target only a small fraction of the human proteome, while compounds that can be programmed to target specific genes could address many relevant disease mechanisms, right at their basis. In aim 1, I will engineer STFs that can (1) bind to any given DNA base pair triplet and (2) enter cells. To achieve these goals, I will develop design rules for preparing minimized ?-helical scaffolds derived from zinc finger protein domains. Via peptide stapling, I will stabilize the structure of these STFs and boost their cell internalization. I will use a high throughput combinatorial screening methodology developed by me to optimize the STFs? properties. In aim 2, I will prepare multimeric STFs (consisting of multiple monomeric STFs from aim 1) that can target unique genes within the entire human genome with high specificity. I will obtain them with a combination of solid-phase and bioconjugation strategies. With a hexameric STF (recognizing 18 DNA base pairs), I will target a specific gene promoter and trigger ?-globin production as a promising strategy for sickle cell disease treatment. In aim 3, I will use STFs to disrupt cancer-related liquid-liquid phase-separated transcriptional condensates. Transcriptional condensates rely on a network between transcription factors, DNA, and coactivators, and they play a crucial role in gene transcription. With STFs, I will displace the oncogenic transcription factor MYC from its DNA binding site. I expect this interference to lead to a condensate disruption and to downregulation of oncogenic MYC-dependent transcription. SynTra will deliver powerful and practical synthetic tools for studying and targeting disease mechanisms. Researchers at the interface of biology and chemistry will use the STFs developed in SynTra, for basic research and drug development.

Keywords: chemical protein synthesis peptide synthesis synthetic peptide modification cell penetrating peptides transcription factors
Manuscript Culture in the Age of Print (PRIMA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2499369.0
EU funding (EUR): 2499369.0
Participants: 1
Project status: SIGNED

The PRIMA project will redefine our understanding of how culture was produced and disseminated in Early Modern Europe (1575-1800). PRIMA will uncover the importance and the scale of manuscript production and publication for literature, science, music, and other areas, for a period when print is believed to be the dominant (if not the only) technology for publication. By investigating the indissoluble connection between text and carrier, PRIMA will explore how manuscripts have shaped society for much longer than believed. The PRIMA project will unveil the rich manuscript culture that hides in the plain sight of scholars and answer why so many manuscripts were produced, by whom, for whom and how. We will assess the existence of modern scriptoria, uncover monastic writing practices in the modern period, and focus on manuscript production within universities and academies. For literature, particularly satyric and lyric poetry and theatre, it is our argument that manuscript dissemination is the norm and that print is exceptional. We will focus particularly on Italy while allowing for significant openings towards other cultures. Italian manuscript production and consumption are both exceptionally rich and understudied. Adopting qualitative and quantitative methods and innovative computational approaches for data mining, production, and retrieval will ensure the project's feasibility. The investigation of post-print manuscripts will uncover unknown works, which will help redefine our understanding of literary production for the 17th through the 18th centuries by fighting teleological prejudices about the inferiority of manuscripts with respect to print from the 16th century onwards. Finally, PRIMA will also investigate cases of print/manuscript hybridisation, where manuscripts imitate print or include printed sections. The project's main outcomes are the creation of a new discipline and a centre for Modern Manuscript Studies, a book collection and an OA.

Keywords: manuscript studies,litterature
Identification of TILs-specific novel lincRNA and their functional importance in mediating immune response in renal cell carcinoma (REGULINC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 226276.8
EU funding (EUR): 226276.8
Participants: 1
Project status: SIGNED

One of the top ten tumors that occurs worldwide most commonly is renal cell carcinoma (RCC) and its incidence is increasing. Regulatory T cells (Tregs), expressing transcription factor FOXP3, play a critical role in the suppression of inflammatory responses maintenance of self-tolerance. However, within the TME, Tregs contribute to tumor development and progression by reducing antitumor immune responses and promoting tumor growth. The dysregulation of specific lncRNAs has been correlated with the prognostic outcomes of patients with RCC, whereas the lncRNA dysregylation in tumor infiltrating lymphocytes is unclear. The overall objective of REGULINC is to increase our understanding of the role of both known and novel lincRNAs in governing the function of regulatory T cells (Tregs) present in the tumor microenvironment (TME) of RCC. This study will identify for the first time the TILs-specific lincRNAs – with a focus on Tregs, and their role in Treg interactions with other immune cells in RCC samples. REGULINC will probe into the role of novel lincRNAs in the stability of Tregs and their cell-suppressive capacity, and ascertain if modulation of selected lincRNAs could result in enhanced immune response by TILs in the TME. The project will gain new mechanistic understanding of how lincRNA network defines Tregs activity in TME of RCC. It will also develop novel tools for therapeutic intervention through specifically targeting immune-suppressive Tregs to boost immune response in the TME of RCC.

Keywords: long non coding rna,tregs,tils,crispr
Highly efficient technologies for increased yields in steelmaking processes and reduced environmental impact (HIYIELD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Clean Steel (co-programmed)
Countries involved: Sweden,Italy,Greece,Germany,Austria
Call: Improvement of the yield of the iron and steel making (Clean Steel Partnership) (IA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-07-01
End date: 2025-12-31
Duration (months): 42.0
Total project cost (EUR): 5468090.25
EU funding (EUR): 3583262.75
Participants: 9
Project status: SIGNED

Steelmaking is a key process for a climate neutral, circular and digitized production. On one hand it enables green technologies in providing the most relevant materials needed to achieve climate neutrality, on the other hand it accounts for 7% of total world CO2 emissions. Its transition towards a more sustainable and still competitive production requires to increase the use of scrap to minimize the pig iron usage from coal fired blast furnaces with inherent CO2 emissions from reducing the iron ore. Furthermore, scrap can be valorised by use of carbon carriers and containing alloying elements in steel scrap, e.g. in recycling of Mn steels. HIYIELD aims to promote circular economy by progressively increasing the scrap uptake in three scenarios that represent the current European steelmaking routes. With the ambition to deliver solutions with relevance to all steelmakers, the consortium includes three producers with different portfolio. Main objectives are: - to maximise scrap quality by optimal technologies for removal of impurities and optimal use of alloying elements - to maximise scrap use by improved scrap identification and classification together with scrap tracking in circular economy - to maximise product quality with further scrap uptake by charge optimization and ensuring the liquid steel analysis and thus the final steel product quality HIYIELD contributes to the fight against climate change and to the EU steel industry competitiveness through the application of highly innovative methods and technologies to the steel sector such as: - Deep Learning based Computer Vision for scrap identification and control - Digital Scrap Information Card for scrap tracking - High Speed Sampling and analysis to avoid waiting times for steel analysis.

Keywords: sustainable steelmaking,scrap uptake,process yield,online characterization
Heterogeneous Asymmetric Nanocluster-catalysis Design (HAND)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1993224.0
EU funding (EUR): 1993224.0
Participants: 1
Project status: SIGNED

Chirality plays a major role in several areas due to the different behavior of each enantiomeric form of a compound, critical in the pharmaceutical industry. Obtaining pure enantiomers is one of the most difficult challenges, in which homogeneous asymmetric catalysis has achieved significant steps. Now it is time to undertake the challenge by heterogeneous enantioselective catalysis, implying great advantages in terms of sustainability, and offers further opportunities for in-depth understanding of mechanisms at the molecular level, relevant in multidisciplinary fields. However, successful design of such processes requires understanding and control of all relevant steps, which requires well-defined catalysts designed at atomic level. A new class of atomically precise nanomaterials that offers ample opportunities to explore chirality at the fundamental level, are the monolayer protected metal nanoclusters, which exhibit unexpected catalytic and intrinsically chiral properties. The HAND project aims to tackle actual challenges in heterogeneous asymmetric catalysis and achieve enantioselectivity with chiral nanoclusters on surfaces designed at atomic level. After creating chiral clusters active in homogeneous asymmetric reactions, we will control their immobilization on the support surface and their chiral properties. Such atomically precise chiral surfaces will allow us to overcome sensitivity barriers of available chiral spectroscopic techniques, improving studies of chirality at surfaces. Finally, having a well-defined chiral surface, asymmetric/enantioselective model reactions will be explored, aiming to obtain pure enantiomers. Each process step by itself represents a novel pioneering work in the field of nanoclusters and asymmetric catalysis, so far mostly unexplored. The fabrication and understanding of such a new class of chiral surfaces at the atomic level represent a breakthrough in knowledge relevant for materials science, nanotechnology and medicine.

Keywords: chirality,gold nanoclusters,ligand exchange,spectroscopy,asymmetric hydrogenation reaction
High voltAge, modulaR and low weight electric POwertrains fOr NExt generation waterborne tRanSport (HARPOONERS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Partnership: ZEWT (co-programmed)
Countries involved: Spain,Belgium,Austria,Norway,Türkiye,United Kingdom,Italy
Call: Achieving high voltage, low weight, efficient electric powertrains for sustainable waterborne transport (ZEWT Partnership) (HORIZON-CL5-2024-D5-01, 2024)
Start date: 2025-02-01
End date: 2028-01-31
Duration (months): 36.0
Total project cost (EUR): 7497595.49
EU funding (EUR): 7497595.49
Participants: 13
Project status: SIGNED

Electrification of maritime and IW vessels shows a low progress, since there are several challenges that need to be overcome before battery energy storage systems (BESS) can compete with other solutions towards the decarbonization of vessels. The main challenges are related to the: (i) weight of the BESS, since a high storage capacity represents a significant share of the vessel’s cargo capacity in small/medium sized vessels, (ii) the reliability so that to ensure the trouble-free routing and reduction of operating and maintenance costs, and (iii) the safety that is the key to enable the large-scale adoption and remove any concern of vessel owners. These three aspects constitute the Innovation Pillars of HARPOONERS, and drive the development of a unique modular concept for interfacing with HV on-board grids, characterized by a high compactness due to the integration of key components in a single configuration, thus eliminating the transformer and a cooling system. This “AC battery system” will be developed together with the management systems for a reliable operation in future powertrains of all-electric or hybrid vessels with reduced emissions. The outcome is a reduced weight, reliable and safer BESS that will allow the uptake of the HARPOONERS solution in both maritime and IW vessels, to further increase the battery capacity and achieve a longer autonomy. This is extremely beneficial in small/medium vessels, in which full electrification will be possible, thus eliminating the use of the combustion engine and its associated CO2 and other emissions, but also on large vessels in which the HARPOONERS solution with less use of raw materials will lead to a reduced environmental impact and lower manufacturing and maintenance costs. To achieve this, HARPOONERS has gathered a balanced European-wide partnership with organizations from the key value chains, such as research, battery system and power electronics manufacturers, shipping owners, and a Classification Society.

Keywords: hybrid power electronics chemistry agnostic ac battery system high voltage bms ems architecture digital twin platform safety life cycle plan
High Dimensional Probability and Combinatorics (HighDimProbComb)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 1499408.75
EU funding (EUR): 1499408.75
Participants: 1
Project status: SIGNED

This project concerns three related topics concerning high dimensional probability and combinatorics. The first part concerns fundamental questions concerning random matrices. These include the problem of finding sharp bounds on the singularity probabilities for discrete random matrices; and determining the limiting spectral distributions of ``sparse'' matrix models. The second major goal of this project is to make progress on the hypergraph Ramsey numbers and the multi-colour Ramsey numbers. These are two absolutely central objects in combinatorics which remain mysterious in many respects, despite many years of intense activity. Finally, I propose to study the Chowla cosine problem. This is an old problem in the area of harmonic and Fourier analysis which the PI has recently been studying through a probabilistic lens.
Bringing EU-SOLARIS ERIC to its Zenith (SOLARIZE)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Spain,France,Germany,Cyprus,Portugal,Italy,Greece,Türkiye
Call: Consolidation of the RI landscape – Individual support for evolution and long-term sustainability of pan-European research infrastructures (HORIZON-INFRA-2023-DEV-01, 2023)
Start date: 2024-07-01
End date: 2027-12-31
Duration (months): 42.0
Total project cost (EUR): 4468405.0
EU funding (EUR): 3557637.54
Participants: 12
Project status: SIGNED

The SOLARIZE project intends to enhance the long-term sustainability of the EU-SOLARIS ERIC by successfully achieving its general objectives: enlargement of the membership; further involvement of R&D institutes and national funding institutions at the National Nodes; educating new researchers to make appropriate use of the RIs; reinforcement of international cooperation and of science diplomac; improvement of the managerial skills of its staff; strengthen the interaction between industrial stakeholders and CST researchers; increase of the general awareness of other possible applications of CST RIs, e.g. industrial process heat; development of new standards and testing protocols; creation of the first e-infrastructure providing Remote/Virtual access to the R&D centres; study of best ways to combine CST with other energy sources and last but not least, targeting the greening of technologies and methodologies used by the CST RIs.

Keywords: solar energy,concentrated solar power,solar thermal,research infrastructure,innovation,sustainability