Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
AI for Predictive Maintenance on Wind Turbines (PAVIMON)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-10-01
End date: 2020-02-29
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Wind power is a key component in the transition towards a society based on renewable energy. However, wind turbine operation and maintenance costs remain high and represent a third of the total costs of energy. Maintenance of critical components can be drastically reduced through early fault detection using advanced sensor signals. However, current analysis methods are highly manual and do not scale well. The EU-funded PAVIMON project is focused on the implementation of advanced artificial intelligence (AI) to analyze data from these sensor streams. The aim is to increase the resource efficiency of signal analysis and improve predictive capabilities. The PAVIMON project will effectuate a feasibility study at technical, transformational and commercial levels.

Keywords: predictive maintenance,wind turbine oandm,asset health monitoring
Structure and Function of the Bacterial Transformasome (TransfoPneumo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: France,France
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 1999920.0
EU funding (EUR): 1999920.0
Participants: 2
Project status: SIGNED

Natural genetic transformation, first discovered in Streptococcus pneumoniae by Griffith in 1928, is observed in many Gram-negative and Gram-positive bacteria. This process promotes genome plasticity and adaptability. In particular, it enables many human pathogens such as Streptococcus pneumoniae, Staphylococcus aureus or Neisseria gonorrhoeae to acquire resistance to antibiotics and/or to escape vaccines. For natural transformation to occur, bacteria must develop a highly regulated physiological state called competence, during which a multiprotein machinery, designated as the transformasome, is specifically expressed. The transformasome drives the uptake of extracellular DNA and its subsequent integration into the bacterial genome. This intricate system can be divided into three functional entities: the transformation pilus, the DNA entry pore and the recombination apparatus. The architecture and function of the transformasome remains largely elusive. We propose to dissect the structure and function of this system in the human pathogen Streptococcus pneumoniae. We will combine four complementary approaches to attain our goal: (1) Molecular biology and biochemical studies in vitro (2) Structural biology on purified proteins or protein complexes using X-ray crystallography and cryo-electron microscopy (3) Structure-function studies in vitro and in vivo (4) Structural biology in situ using cryo-tomography. Overall, we believe this ambitious project will provide major insights to understand the molecular basis of bacterial transformation, a fundamental process in bacterial physiology. In addition, this project may provide new strategies to reduce pneumococcal adaptation during infection.

Keywords: membrane protein complexes
Biocatalytic flow reactors using extremophilic enzymes for a greener generation of aroma-compounds (AROMAs-FLOW)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

In tune with sustainable chemistry, the use of enzymes for synthetic purposes has indeed drawn much attention as it is seen as an eco-friendly process. From another perspective, flow reactor technology represents one of the new strategies introduced in last few years to advance sustainability of organic synthesis and shows many advantages compared with traditional batch methods, including improved heat and mass transfer, efficient mixing of substrates and shorter reactions time. AROMAs-FLOW innovative strategy involves a combination of flow reactor technology and biocatalysis to create an efficient and modern platform oriented to a green production of natural food compounds and capable of extraordinary versatility and reaction innovation. The excellent opportunities offered by using immobilized biocatalysts under flow reaction conditions, represent a research field of certain growth. Twenty target aroma-compounds, three types of enzymes as well as acetic acid bacteria as whole cells have been selected to focus the efforts on specific synthetic problems, and to efficiently implement knowledge transfer to practical applications. The innovative AROMAs-FLOW project will offer an attractive economical incentive to the food industry because of consumers’ preference for natural products, attributed to increasing health- and nutrition-conscious lifestyles, as well as an alternative to traditional agriculture at risk of possible shortages caused by local condition production (climate, pesticides etc.) and the responsible care of natural resources. Furthermore, alternative “natural” routes for flavours production in addition to plants extraction, are becoming increasingly appealing. In agreement with Europe 2020 strategy, the outcomes of my research will reduce the cost of energy consumption and chemical waste with a significant economic and environmental impact on the society.

Keywords: biocatalysis,flow chemistry,aromas,flavours,sustainable processes,natural products
Onsite, On-demand, Self-standing Cost Competitive Zero-Carbon Power Generation (RenGen)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Denmark
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

RenCat is developing and commercializing a unique zero carbon fuel cell based power generator that uses ammonia as fuel and our technology gives over 40% cost savings compared to diesel generators.

Keywords: zero carbon fuel cell
Defendable legal cases through an affordable, easy, integrated and reliable case management software (eDCaseMAN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Electronic discovery (known as e-discovery) is the electronic aspect of identifying, collecting and producing electronically stored information (ESI) in response to a request in a lawsuit or investigation. The Electronic Discovery Reference Model (EDRM) is the stablished and accepted framework by e-discovery practitioners. Commonly, the "left-hand side" of EDRM is used to refer to the steps containing information governance, identification, preservation and collection through legal hold requests (Hold/Preserve/Collect) and the "right-hand side" refers to processing, review, analysis, production and presentation (Processing/ Review/Production). Currently the market offers solutions to right-hand side of the EDRM model at the expense of the left-hand side. However, this forgotten part of e-discovery process is complex and offers multiple opportunities for errors. These errors increase operational costs, lead to potentially expensive sanctions, adversely affect the organization’s reputation and negatively affect employee morale. Fortunately, our product – eDCaseMAN – can mitigate the chaos by transforming the left-hand side of the e-discovery into a mature business process. eDCaseMAN is an intelligent, integrated evidence management software solution that solves the administrative e-discovery process challenges. For the first time ever, case managers will be able to track, trace and monitor all activities anywhere on any device at any time. We are looking for an SME future SME instrument grant of €1,050,000 to fund product development, develop our IP strategy and run pilot tests. Before this, our company plans to use phase 1 funding to plan a fast, sound and global deployment of eDCaseMAN.

Keywords: legal management,legal tech,e discovery,edrm model,electronically stored information
Big Data of Small Molecules (BDoSM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Slovakia
Call: SME boosting biotechnology-based industrial processes driving competitiveness and sustainability (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

As Google mapped and photographed the streets and terrain of our planet, the main objective of the project is to map and spectrally fingerprint the small organic molecules of various organisms and introduce to the market a fundamentally new cloud driven compound identification platform. Our pioneering solution will allow continuous identity assignment of unknown molecules in biologically relevant samples by developing a technologically mature architecture and infrastructure for storage, processing, search, exchange, analysis, data mining and visualization of millions of spectral, structural, chromatographic and biochemical data of small molecules. Our project will become the world most comprehensive database platform of spectral fingerprints of endogenous metabolites, natural products and environmental contaminants that will allow identification of substances present in biological samples that could not be identified using conventional technology that is a crucial bottleneck in many biotechnological and pharmaceutical applications. Since the biomedical, pharmaceutical and biotechnology industry in general are constantly detecting numerous unknown compounds and searching for new biomarkers and disease specific targets, our technology platform is direct response to their needs with the prospect of new business opportunities and future growth. The feasibility study will be important for acquiring additional financing of the project, to review technological solution (most effective and sustainable, without infringing patents, copyrights, and trademarks of third parties), to precise marketing strategy for corporate, small group & individual users, to identify, clarify and protect own inventions, new approaches and new technical solutions. Finally, the Phase 1 outputs will give perfect review on project management plan.

Keywords: mass spectrometry,small molecules,data platform
Evolution of Rose Gall Tritrophic Communities (RoseTriComm)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Tritrophic communities of plants, insect herbivores and associated parasitoid natural enemies together comprise more than 50% of all described species, including both beneficial ecosystem service providers and major economic pests. A key aim in ecology is to understand the processes that form this spectacular diversity and its complex interactions. This project (RoseTriComm) aims to answer two key questions: (a) Do plant traits also influence the diversification and assemblage structure of natural enemies? (b) Do natural enemies exert their own ‘top-down’ effects on herbivore diversification and assemblage structure? Our approach will assess the support for these alternative paradigms using an unparalleled dataset that combines trophic interaction, trait and phylogenomic data for plants (roses, 80 species), herbivores (rose gall wasps, 50 species), and parasitoids (ca. 100 species) from North America and Europe. This innovative research is the first application of the co-phylogeny framework to a large scale tritrophic system, examining the role of traits in structuring interactions in a multicontinental context. Furthermore, RoseTriComm will allow us to develop an analytical framework that can be applied to understanding any tritrophic system’s diversity and assemblage structure. The ability to anticipate the cascading impacts of species gains or losses, is more important than ever when biodiversity is increasingly vulnerable to threats such as climatic change. Finally, RoseTriComm will contribute to train and strengthen the fellow’s research skills in project management and grant writing, expand his network of collaborators, produce high-impact publications, and enable research dissemination via conference communications and public outreach.

Keywords: evolution of tritrophic interactions,insect plant interactions,macroecology,evolution of extended,phenotypes
NEFERTITI: A Novel Eco-Friendly, dually Efficient and Resistance-free Treatment of vaginITIs (NEFERTITI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

This project will develop a business plan to guide clinical validation and commercialization of pHyph, a novel treatment targeting vaginal yeast and bacterial infections. Bacterial vaginosis (BV) and vulvovaginal candidiasis (VCC) are common vaginal infections caused by bacteria (often Gardnerella) or yeast (a fungus) called Candida. 450 million globally experience at least 4 vaginal bacteria or Candida infections each year. It causes significant discomfort, adversely affects quality of life and is associated with heavy socioeconomic burden. To date, all treatments are limited to antifungals and antibiotics that show low efficacy and high relapse rate. With prolonged usage, misdiagnosis, and overconsumption, there is a high incidence of drug resistance, which the WHO considered one of the biggest threats to global health. Gedea has developed a vaginal tablet that contains the natural substance Glucono-δ-lactone (GDA), which switches Candida towards a benign yeast form, restores vaginal pH and disrupts the Candida and bacteria biofilm without causing treatment resistance. The yeast is removed through vaginal discharge. Since this is an antibiotic-free treatment, healthy bacteria that normally keep Candida at bay are also not removed and therefore a low relapse rate is expected with the use of pHyph. The product’s key feature lies in its ability to treat both yeast and bacterial infections and its use as both a preventative and curative treatment. These features are unmet by any other product on the market. Preclinical research performed to date strongly supports pHyph’s novel mechanism to treat vaginal infections, reduce recurrent infections and eliminate the need for antibiotics/antimicrobials. The proposed project will further prepare pHyph for a clinical trial. SME Instrument funding will allow Gedea to close the gap on the road towards commercialisation.

Keywords: vaginitis,recurrent vulvovaginal candidiasis,yeast infection,bacterial infection,bacterial vaginosis
Functional 2D metamaterials at visible wavelengths (FLATLIGHT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France,France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2021-10-31
Duration (months): 74.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: CLOSED

For the last 15 years, optics has undergone a remarkable evolution towards ever decreasing sizes, better integration in complex systems, and more compact devices readily available to mass markets. Whereas traditional optics is at the centimeter scale, newly developed techniques use nanoscale objects to control, guide, and focus light. From the capability to shape metallic and dielectric nanostructures has emerged the field of nanophotonics. Advances in nanophotonics offer the possibility to control the material’s optical properties to create artificial materials with electromagnetic properties not found in nature. Man-made 3D metamaterials have interesting fundamental aspects and present many advantages with respect to conventional devices. Unexpected effects have led to the development of interesting applications like high resolution lenses and cloaking devices. Inspired by this new technology, we have developed new 2D metamaterials. Our flat metamaterials (metasurfaces) are much simpler to manufacture than their 3D counterparts. By depositing a set of nanostructures at an interface, we can immediately control the light properties; unlike refractive optical components, the wavefront is modified without propagation. As of today, these interfaces are created using metallic nanostructures and work in the infrared. In this ERC, we plan to extend the concept of optical metasurfaces in the visible which is the most important wavelength range for applications. By combining with optically active semiconductors such as InGaAlN, we will add optical gain and modulation capability to the system to create new, efficient optoelectronic devices. The response of the metasurfaces is tunable by changing the environment surrounding the nanostructures. We will use this property to create ultrathin reconfigurable flat devices. Metasurfaces will be integrated with AlN/GaN to modulate light at high frequencies and further exploited to control polariton gases in solid state metasystems.

Keywords: metamaterials,metasurfaces
Efficient electronic transport at room temperature by T-shaped molecules in graphene based chemically modified three-terminal nanodevices (Tmol4TRANS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-03-01
End date: 2023-08-31
Duration (months): 78.0
Total project cost (EUR): 1998879.0
EU funding (EUR): 1998879.0
Participants: 1
Project status: SIGNED

Tmol4TRANS aims to create operative molecular systems that will efficiently be inserted in three-terminal nanodevices to function as transistors at room temperature (RT). In the front-line of molecular electronics, the implementation of functional nanodevices in present technologies is mainly hampered by crucial unresolved issues like: a) reliability of RT experiments on molecular transistors; b) absence of controlled methodologies to deposit single molecules at specific sites; c) low conductance values and d) difficulties in achieving effective three-terminal devices (BJTs/FETs). Such hindrances involve the nature of the molecules, the absence of controlled deposition methodologies at the nanoscale and the poor stability/contacts between molecules and electrodes. Stable two-terminal nanodevice based on few-layer graphene and containing a Curcuminoid molecule (CCMoid) that I made has shown reasonable molecular conductance at RT, where the CCMoid anchors to the electrodes by pi-pi stacking. The specific goals of Tmol4TRANS are: 1) to synthesize multifunctional molecules base on “T-shaped” CCMoids and Porphyrin derivatives (PPDs) allowing efficient attachments to electrodes; 2) to fabricate chemically functionalized hybrid graphene transistors; 3) to establish a reliable methodology for positioning the molecules between the electrodes; 4) to investigate the conductance enhancement of the final systems, and 5) to provide the possibility of spin-dependent transport properties by binding such molecules to magnetic metals. Here, the preparation of nanodevices involves feedback-controlled burning technique for the formation of the few-layer graphene electrodes (source/emitter and drain/collector) and the chemical functionalization of the gate/base, where T-shaped molecules will be fixed by click-chemistry. Tmol4TRANS would have a direct impact in Molecular Electronics and Spintronics, as well as in the broader scope of nanoelectronics.