Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A novel approach for modelling the human nose-brain axis in vitro (Micro-SENSE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

Olfactory neurons allow circumventing the blood-brain barrier making this route particularly interesting for the non-invasive intranasal treatment of brain diseases (Alzheimer’s Disease). Moreover, commensal nasal microbes present in the respiratory region, the major surface of the nasal cavity, are assumed to induce health-promoting effects via metabolites as the gut or skin microbiome does. These complex nasal host-microbiome interactions are emphasized when considering that olfactory neurons sense bacterial metabolites like odorants and that a loss of smell is associated with an early stage of brain diseases. Demonstrating the importance of the human nose nose-brain axis its mechanisms are incompletely understood due to the use of currently available over-simplified 2D in vitro as well as animal in vivo models. Animal models provide highly valuable insights into cause-effect relationships, but translation to humans is challenging. Thus, within the Micro-SENSE project, we are proposing to build an advanced bioelectronic 3D model of the human nose-brain axis urgently needed for a better understanding of healthy nose physiology. This 3D bioelectronic platform will connect the recently developed (1) e-Transmembrane device hosting a respiratory nasal organoid and nasal microbes, (2) Microelectrode Arrays with affixed intact olfactory tissue and (3) patch-clamp set-ups for specific olfactory neuron studies. Integrated biocompatible PEDOT:PSS electrodes enable non-invasive monitoring and recording of nasal host-microbiome interactions by measuring epithelial barrier integrity and olfactory neuron firing in real time. PEDOT:PSS scaffolds compartmentalize the e-Transmembrane device for connecting with MEAs and patch-clamp set-ups enabling to study drug and metabolite uptake along the brain axis. Genetic and metabolic profiling of the gender-specific nose model will pave the way for optimized intranasal drug delivery targeting olfactory neurons and the nasal microbiome.

Keywords: nose brain axis,gender,nasal microbiome,intranasal drug delivery,olfactory neurons,bioelectronics,3d conducting polymer scaffold,microelectrode arrays
Reversing T cell dysfunction in cancer by multimodal genetic screening (ReverT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2499375.0
EU funding (EUR): 2499375.0
Participants: 1
Project status: SIGNED

T cell dysfunction is a key problem in cancer, enabling not only tumorigenesis but also causing resistance to immunotherapy. Induction of immune checkpoints is a hallmark of T cell dysfunction, but clinical blockade by PD-1 and CTLA-4 antibodies solves this problem for few patients only. Dysfunction is driven also by additional mechanisms, including chronic stimulation and metabolic insufficiency. A better mechanistic understanding will be imperative for improving immunotherapy. My laboratory recently launched “ReverT”, a genome-wide CRISPR-Cas9 screening program to identify genes, ablation of which reverses dysfunction in primary T cells. To de-risk this application, we have already successfully completed three such screens in vitro, for chronic antigen stimulation, metabolic stress and PD-1 induction, validating and characterizing several dysfunction genes not previously reported. Furthermore, an independent follow-up re-screen with a Dysfunction Reversion Candidate (DRC) mini-library containing the top 100 hits of each of these screens validated >100 genes that reversed T cell dysfunction in vitro. Here, we will carry out the most challenging and important step: to systematically validate and mechanistically characterize this collection of T cell dysfunction genes in vivo. This will be done in a pooled and multimodal fashion, analyzing multiple dysfunction phenotypes in parallel, specifically immune checkpoints, exhaustion, metabolism, recruitment and proliferation. Our proof-of-concept results indicate that the DRC library contains “nodal” factors, operating in several seemingly different dysfunction settings, which may thus in fact be linked. We will use a collection of adoptive cell transfer mouse and human tumor models for validation and mechanistic characterization, as well as primary human T cells in patient-derived tumor fragments. Lastly, we will translate our findings to a preclinical setting, aiming to achieve more durable clinical responses.

Keywords: t cell dysfunction,immunotherapy resistance,crispr cas9 screens
OPERATION AND MAINTENANCE AND GRID FRIENDLY TOOLS AND SOLUTIONS FOR SOLAR DATA FUSION AND INSIGHT EXPLOSION FOR RELIABLE, BANKABLE, CIRCULAR PV PLANTS (SUPERNOVA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Italy,France,Spain,Austria,Lithuania,Belgium,Norway,Switzerland,United States,Australia,United Kingdom
Call: Operation, Performance and Maintenance of PV Systems (HORIZON-CL5-2023-D3-02, 2023)
Start date: 2024-04-01
End date: 2027-09-30
Duration (months): 42.0
Total project cost (EUR): 5853976.5
EU funding (EUR): 4906167.0
Participants: 21
Project status: SIGNED

SUPERNOVA will embrace existing proven successful concepts (breaking silos and innovating in sector where R&D&I are usually not a common target) and will integrate them with further disruptive key elements: - O&M and grid friendly design of PV plants thanks to advanced solutions in software for the early design and engineering phase to go beyond yield maximisation. Severe weather events are increasing in frequency and bespoke planning and dedicated mitigation measures must be put in place; - Multilayer approach where standalone solutions can be hybridised and connected in interoperable digital platforms; - Avoid a data tsunami effect on stakeholders by leveraging on AI to manage and govern the immense quantity of data and provide solutions using Instruction Tuned Large Language Models; - Share data with a larger basis to generate value for the data provider and for the data user and study how the process could be also monetized; - Develop solutions related to the use of automated processes that can replace the operator's work in data and image collection, increase the intrinsic value of O&M contracts, free up human resources for data analysis itself and therefore the creation of added value in new services ; - Develop solutions that exploits all the previous key elements towards condition monitoring of PV components in view of circular economy (for e.g., reuse), drive optimal procurement for future projects, provide valuable insights for better services (for e.g. insurance) and ultimately increase profitability. Combining these features SUPERNOVA will innovate in: O&M and grid friendly design including mitigation measures for severe weather conditions, tools and components for multi aspect sensing, robotic solutions and their hybridisation, data fusion to generate AI based controlled insights explosion via federated PV asset management, classify PV components for re-use and create a PV data space.

Keywords: robotic solutions,ai,grid friendly,oandm friendly,profitability,smart control,severe weather mitigation
Proteomic Analysis of Cell communication in Tumors (ProACCT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-08-01
End date: 2027-07-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Cancer is an enormous biomedical challenge, in part due to the complexity of cancer cell dynamics. The combination of intrinsic genetic alterations and cues from the tumour microenvironment impact the cancer phenotype and create heterogeneous tumours that evolve in space and time. Cancer cells develop distinct phenotypes in diverse tumour regions and different metastatic locations. In addition, cancer progression, metastatic dissemination, and development of therapeutic resistance affect cellular interactions over time. Therefore, understanding tumour dynamics is critical for the development of novel therapeutic approaches. Although tumour heterogeneity has been thoroughly investigated at the genomic and transcriptomic levels, limited studies have investigated heterogeneity at the proteomic level. Changes in protein expression are central determinants of cancer phenotypes; developing a detailed understanding of proteome dynamics would be an enormous scientific advancement in the cancer field. However, technological challenges, and specifically, the challenge of analysing single cells and small groups of cells, have delayed progress along these lines. Here, I propose to combine my cutting-edge clinical proteomic expertise and extensive experience in cancer biology to study the spatial and temporal heterogeneity of cancer at the proteomic level. We will push the boundaries of the technology towards assaying thousands of proteins from single cells and small groups of cells from in-vivo samples. We will combine microfluidic probe technology to map primary tumors and metastases at high spatial resolution, and study mouse models of melanoma and breast cancer to follow temporal changes in metastatic growth and treatment response. This breakthrough in proteomic analysis of cancer dynamics will provide the basis for targeting treatment-resistant metastatic cell populations towards advanced personalized treatment.

Keywords: mass spectrometry based proteomics,cancer proteomics,clinical proteomics
Novel optical nanocomposite sensors for analysis of micro and macro elements in corn plants (SENS4CORN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Latvia,Poland,Italy,Slovakia,Ukraine,Lithuania,France
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 1155257.14
EU funding (EUR): 1048800.0
Participants: 14
Project status: SIGNED

SENS4CORN is targeted to strengthen intersectoral and interdisciplinary collaboration in optical composite nanomaterials for optical chemical sensors. The main project goal is development of novel optical nanocomposite sensors for analysis of micro and macro elements in corn plants. We will investigate Schiff bases (SB) and Metal organic frameworks (MOF), optical composites ZnO-SB and ZnO-MOF with advances optical and their sensitive properties towards anions and cations, present in corn micro and macro elements. The sensitive composites will be integrated into microfluidic system, combined with fiber optic detection system. The system will be used to validation of real corn samples. The sensing system will reduce time and cost of the measurements by standard chromatography methods. The sensing system has good potential of commercialization in agriculture sector as a new rapid service for corn growth analysis for small and medium farm companies. The project is interdisciplinary and it involves material science, chemistry, surface science, optical, analytical chemistry, nanotechnology and agriculture. The project will create new service for improvement of agriculture production, thus improving industrial and health potential of EU citizens. During the project, research and management training will be provided to technicians, experienced and early stage researchers to strengthen their personal skills, improve their track record and expertise via new scientific papers and conference presentations and strengthen a development of EU research human resources. Long lasting collaboration between partners, based on co-supervising students and preparation of novel collaborative project proposals is foreseen. Dissemination of project results will make an impact on agriculture sector and EU research potential in the fields of material science, nanotechnology and optical sensors.

Keywords: schiff bases,metal organic frameworks,zno photoluminescence nanostructures,composite materials,optical sensors,ion detection in liquids,sensors for agriculture applications
Multiplexed microRNA detection platform for early diagnosis and patient management (MiRACLE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Early detection of disease on a population scale (screening) relies on highly sensitive testing, able to detect early molecular changes, coupled with cost-effectiveness that enables economic access to such testing at scale. The MiRACLE project addresses these challenges by combining a breakthrough optical sensing approach for single-molecule detection with creative biochemistry and computation. The ground-breaking goal of this research proposal is to develop a robust diagnostic platform capable of detecting disease-induced changes in micro-RNA expression by counting individual RNA molecules directly in bodily fluids without the need for amplification. This innovation will be realized by a novel, computationally assisted single-molecule detection scheme that, unlike common single-molecule detection methods, enables detecting a full panel of biomarkers simultaneously in a single snapshot, offering ultimate sensitivity at exceptionally low-cost. These attributes make this technology suitable for large-scale population screening and health management. Promising preliminary results show that MiRACLE can detect and count individual RNA targets in mixtures of synthetic miRs in physiological sub-femtomolar concentrations. These preliminary results highlight the potential of this approach for ultra-sensitive early detection of disease and a provisional patent has been submitted. Within the proposed project a proof of principle will be performed on a cohort of lymphoma patients and healthy controls that will be classified by the miracle approach. The technology will be benchmarked against existing state-of-the-art methods such as RNA sequencing and quantitative PCR.
Robust and accessible modelling for an effective management of agricultural soil erosion in Europe (iMPACt-erosion)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,United Kingdom
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-01
End date: 2025-11-30
Duration (months): 34.0
Total project cost (EUR): 231534.67
EU funding (EUR): 231534.67
Participants: 3
Project status: SIGNED

Soil erosion represents a serious challenge for agricultural production and for the environment. Soil erosion impacts, such as reduction of fertile soil, alteration of the carbon cycle and pollution and eutrophication of water bodies, represent a significant management concern for the European Union. Modelling approaches can deliver indicators on the state of soil erosion impacts and its trends, and scenarios in relation to climate and land use change. This can help define efficient and targeted mitigation strategies by identifying the long-term controlling factors and the areas where, and periods during which, soil is at high risk of erosion. However, to define such strategies, there remains a lack of modelling approaches a) able to provide with longer term baseline information which to measure the success or otherwise of mitigation strategies at the catchment scale and b) accessible and robust enough to be used, understood and trusted by users with more or less expertise, including researchers, land managers and policy makers. In response, this project will improve improve the robustness and accessibility of quantitative methods for supporting agricultural land management. The objectives of this project are: (i) to develop an accessible soil erosion model, iMPACt-erosion, to support agricultural land management in Europe at the catchment scale, (ii) to apply a robust and multi-disciplinary model evaluation approach to achieve greater confidence in the iMPACt-erosion model predictions and (iii) to identify the soil erosion controlling processes and vulnerable areas and periods to define targeted and effective mitigation strategies until 2100.

Keywords: knowledge transfer model reproducibility global sensitivity analysis
Building vascular networks and Blood-Brain-Barriers through a Biomimetic manufacturing Technology for the fabrication of Human tissues and ORgans (Hop On) (THOR-Hop On)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Spain
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 32.0
Total project cost (EUR): 642500.0
EU funding (EUR): 642500.0
Participants: 2
Project status: SIGNED

The EIC Pathfinder THOR project aims to revolutionize personalised medicine through the creation of patient-specific neural-vascular structures. THOR tissue will arise from high-resolution 3D spatial positioning of biomaterials, angiogenic factors and relevant cell lineages performed by the coordinated action of cutting-edge spider-inspired mini robots (spiderbots). Programming THOR spiderbots for the rapid creation of functional structures is a significant challenge as different spiderbots must operate within millimetre space tissues, placing fibers and cells with a sub-micron precision and 1-second activation resolution. Indeep AI (IAI) will join the THOR consortium within the WIDERA Hop-On Facility program to provide innovative methodologies to ensure optimal working trajectories for the spiderbots with real-time feedback and adjustments. IAI will develop digital maps for spiderbots' orientation, it will create 3D representations of the THOR working space to facilitate the understanding of their spatial relationships and finally, it will establish a closed-loop feedback system based on Reinforcement Learning algorithms, allowing real-time adjustments to the spiderbots' trajectories to prevent collisions. The new advancements will be integrated within the THOR workflow and validated by generating rodent/human dentate gyrus of the hippocampus. The Hop On project will support the THOR project’s impact including i) enhanced tissue replication for improved personalisation, ii) accurate spiderbot trajectory control to boost clinical applicability, iii) support on future regulatory approval via data traceability, iv) reinforcement of THOR's IP rights with additional patentable assets. Being an SME with experience in technology transfer, IAI will also support future commercial exploitation, enhancing networking, stakeholder outreach, and academia-industry partnerships.

Keywords: 3d spatial positioning closed loop mini bots programming reinforced learning personalised medicine tissue engineering
Swimming Giants: Illuminating the super-massive-binary and gas interaction (SwimmingGiants)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: SIGNED

Nearly all galaxies in the universe harbor a super-massive black hole (SMBH)---with mass a million to a billion times that of our sun---in their core. When these galaxies merge, their super-massive black holes are brought together to form a super-massive black hole binary that interacts with the newly forming galaxy's stars and gas. A cosmic population of these super-massive binaries is hypothesized as the source for the gravitational wave background (GWB) detected for the first time this June. The full evolution and ultimate fate of these binaries, however, remains one of the most enduring mysteries in astrophysics. A key element to revealing the destinies of these binaries and unlocking their multi-messenger observational prospects is to understand their late-stage interactions with ambient gas in the nascent galactic nucleus. In the proposed research program, I will deploy state-of-the-art hydrodynamics simulations of the mutual interaction between compact super-massive binaries and their gaseous environments to develop cutting-edge models of gas-driven binary evolution and its associated observational signatures. These models will be essential to current and forthcoming electromagnetic and gravitational wave observations as the GWB detection (and upcoming LISA mission) open the floodgates on the next-generation of multi-messenger astrophysics and cosmology with super-massive binaries; just as the first LIGO detection did for their stellar-mass counterparts 8 years ago. The Niels Bohr Institute in Copenhagen is the ideal location for me to pursue this research program because of their long-standing history and expertise in numerical hydrodynamics, astrophysical gas dynamics, and gravitational wave phenomena; and the Marie Curie Fellowship would enable substantial development of my skills as a researcher, educator, and communicator in order to achieve my goal of eventually leading an independent research group as a professor.

Keywords: accretion phenomena,binary black holes,gravitational waves