Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Graphene-Assembled Inorganic Hollow Fibre Membranes and Membrane Modules for Water Treatment (GRAPHENEHF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-03-01
End date: 2016-02-29
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

Membrane-based filtration technologies nowadays are standard separation processes and widely used in water treatment. The performance of membranes is however limited by their thickness. This project combines the cutting-edge technologies of membrane fabrication and the science of graphene materials to realize high-performance graphene membranes for water treatment purposes. This project will develop graphene membranes supported by inorganic hollow fibre substrates. The thickness of the graphene membrane layer will be less than 5 nm and down to one C-atom layer, with a nominal pore size from 0.3 to 20 nm. The graphene hollow fibre membrane will be able to used in water treatment and overwhelm other membranes with the same pore size by at least fifty times higher permeation flux. Furthermore in this project we will assemble membrane modules of above graphene hollow fibre membranes and build a lab-scale demo plant to evaluate the applicability of the graphene membrane modules in real applications. By the research of this project, a set of methodologies and knowledge of preparing graphene hollow fiber membranes and membrane modules will be developed.

Keywords: graphene membrane,inorganic hollow fibre,filtration,water
A new intracellular metabolic timer mechanism to induce cell death selectively in cancer cells (PEROXIREDOXIN-CLOCK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-08-04
End date: 2016-08-03
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

Peroxiredoxins (PRX) are at the heart of mechanisms gating the spatiotemporal distribution of ROS molecules within the cell and thereby deeply involved in the development or progression of disease. With the host group’s recent discovery on the circadian nature of PRX-hyperoxidation cycles, PRXs emerge to be tested for driving the physiological 24 h periodic fluctuations of the cellular redox state and ROS-signaling, both being critical in cell cycle control. The potential of the PRX-clock to robustly orchestrate cell cycle progression or apoptotic pathways will be analyzed in the proposed multidisciplinary study. The working hypothesis of the project is that this new timing mechanism operates even in rapidly proliferating cells and that it can be manipulated to deteriorate cancer cell survival selectively. Identification of new ROS-regulated targets promoting apoptosis specifically in transformed cells will have a huge impact on cancer therapy. At the host Institute in Cambridge, U.K., the Fellow will reveal post-transcriptionally regulated targets of PRX and their involvement in ROS-signaling and apoptosis induction in cancer. Through this project he will be able to address hot scientific issues and do important science in the future; furthermore, he will learn many new creative ways of thinking applied by world-renowned researchers in Cambridge. Know-how acquired during this training will open new intersectoral dimensions (Cell cycle biology, ROS biology) for the Fellow, and the evaluation of data obtained during the project will strengthen his interdisciplinary way of thinking.

Keywords: circadian clock,cell cycle,reactive oxygen species,cancer,apoptosis
Development of solid state NMR methods at 100 kHz magic angle spinning frequency for the study of internal protein dynamics and the application to membrane proteins (SOLID_NMR_DYNAMICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-06-01
End date: 2016-05-31
Duration (months): 24.0
Total project cost (EUR): 199317.6
EU funding (EUR): 199317.6
Participants: 1
Project status: CLOSED

This proposal concerns the development of new solid-state NMR methods using proton detection under Magic Angle Spinning (MAS) with frequencies up to 100 kHz. The 100 kHz MAS probe head is a prototype and will allow significant gains in sensitivity by scaling down the 1H-1H dipolar coupling interaction and resulting in narrow proton line width down to 10-20 Hz. Small quantities of protein samples in the range of 0.3 to 0.5 mg allow a signal-to noise ratio that exceeds that of tens of mg in a bigger rotor at lower MAS frequency. A focus of this proposal is the development and optimization of methods to reliably determine backbone dynamics in the solid state under 100 kHz MAS condition, based on 15N R1 and R1ρ relaxation rates as well as transverse 15N CSA/ NH dipolar cross-correlated relaxation rates and NH dipolar couplings that are sensitive up to the microsecond time scale. The experimental analysis will be supported by spin dynamics simulations. 15N T2 relaxation measurements remain a challenging task, as significant differences between bulk T2 measurements using a spin-echo sequence and T1ρ measurements show. We want to compare those measurements at 100 kHz MAS and rationalize systematic differences by spin dynamics simulations. Second, bulk T2 decay times will be estimated for different in- and anti-phase coherences, present in higher-dimensional backbone spectral assignment experiments. Scalar coupling-based INEPT and CP-based polarization transfers will be compared in terms of efficiency. Aim is to minimize loss of magnetization during transfer steps with unfavorable T2 decay properties or insufficient dipolar transfer efficiency and to design an optimized set of experiments for backbone assignment at fast MAS. Methods will be developed on the small protein ubiquitin, a well-studied model system, with the aim of transferring it to a membrane protein, e.g. the HIV viral protein envelope protein gp41.

Keywords: solid state nmr,protein dynamics,magic angle spinning,ubiquitin,membrane proteins,methods development
Evolutionary dynamics of growth factor production in cancer cell populations (DUNHARROW)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Switzerland
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-09-01
End date: 2017-08-31
Duration (months): 36.0
Total project cost (EUR): 375806.4
EU funding (EUR): 375806.4
Participants: 2
Project status: CLOSED

Cancer is a process of clonal selection, and analytical methods from evolutionary biology should be able to explain why cancer tissues are heterogeneous and develop resistance to current therapies. Evolutionary game theory helps understand non-intuitive properties of the frequency-dependent dynamics arising in the cooperative interactions between cancer cells. In particular, the theory of N-person non-linear public goods games is used to analyse the evolutionary dynamics of the production of diffusible molecules like growth factors, which are essential in the development of cancer. Models that take into account general features of non-linear public goods in structured populations, as well as specific features of certain types of growth factors, are used to understand the ultimate causes of tissue heterogeneity and of the evolution of resistance to therapies. The second part of the project uses experiments with cancer cell populations in vitro to test the predictions of the theory. Two types of beta cells from insulinomas of mouse, one of which knocked out for insulin-like growth factor-II (IGF-II), a factor that promotes cancer cell proliferation and survival, are used for experimental evolution in vitro. It is anticipated that IGF-II-deficient tumour cells, while unable to grow in the absence of IGF-II, will proliferate better than producer cells when IGF-II is provided exogenously or by co-cultured producer cells, making IGF-II a public good, and providing an example of cooperation among cancer cells. The results will help understand stable intra-tumoural cell heterogeneity, why therapies that target growth factors lead to a temporary reduction in tumour growth followed by relapse, and may help devise evolutionarily stable therapies.

Keywords: evolutionary biology,game theory,clonal evolution,cancer dynamics,public goods,cooperation.
The Reception of Irish Literature in Italy: 1900-1950 (ITALIANIRISH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

This research project aims to investigate crucial aspects of the reception of Irish literature in Italy during the first fifty years of the twentieth century, with special attention to the politics of translation and mediation in the fascist era. Having devised a theoretical framework that combines cultural and translation studies with evidence-based historical research, I will read archival evidence in the light of recent scholarship on cultural mediation/translation, and discuss the strategies adopted by translators, publishers and intellectuals in their attempt at introducing Irish literary products within Italian culture. This study will ascertain whether or not the Italian cultural system recognized Irish specificity within Anglo-American literature and, if so, in which ways such specificity was articulated. In order to investigate this topic, the research work will analyse both publications about Ireland and translations of Irish literary works, as well as the role of key mediating figures. This study will therefore explore how foreign literatures entered and affected the Italian cultural system, and will focus on Irish literature as a significant and yet understudied case. It will produce a "cartography" of the reception of Irish literature in Italy, while assessing the degree of awareness in Italy of the distinctiveness of Irish literature. The composite portrait of the various images of Ireland in Italy will also provide significant information about both Italian culture and its mediators, and consequently enhance our understanding of intercultural dynamics in early twentieth-century Europe.

Keywords: italian studies,irish studies,translation studies,reception studies
Enabling Audiovisual User Interfaces for Multisensorial Interaction (ENABLING AVUIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-05-01
End date: 2016-04-30
Duration (months): 24.0
Total project cost (EUR): 299558.4
EU funding (EUR): 299558.4
Participants: 1
Project status: CLOSED

The research proposes the notion of AVUI (AudioVisual User Interface), a multisensorial interface combining user interaction with interrelated sound and image. In AVUI, a user interaction brings upon interrelated sonic and visual feedback. AVUI combines Human-Computer Interaction (HCI), sonification, and audio visualisation techniques, aiming to create a cognitive totality or “gestalt” in the user, where different sensorial elements reinforce the interaction. Multitouch, gestural and multimodal interaction are identified as important application fields. AVUI is not exclusively utilitarian, having an aesthetic purpose and user experience concern. The research aims to answer the following question: how can interconnected sound and image be used to create more usable, accessible, playful and engaging user interfaces for multitouch and gestural interaction? The main objectives of the research are to: increase our knowledge on how interaction can be represented by sonic and visual means; identify the successful approaches to sound visualisation that generate greater engagement; improve our understanding of how sound visualisation can allow for greater usability, and accessibility with impaired users; and identify use cases where AVUI can be preferable to the traditional GUI (Graphical User Interface). Following a practice-based and design-oriented approach, and in order to achieve knowledge regarding AVUI, a succession of artifacts will be developed: an initial prototype, two case-study applications implementing AVUI, and a software library for generic deployment of AVUI. These will be subject to user tests, evaluated based on qualitative and quantitative methods, using interviews, cognitive walkthrough, video observation, and questionnaires. The main outcomes will be: functioning systems, code base, and software library for implementing AVUI; interaction theorization of audiovisual elements in the user interface; best-practice guidelines; and outreach activities.

Keywords: human-computer interaction,user interface,gestural interaction,multitouch,multimodal interaction,multisensorial,audiovisual,sound visualization,user experience,accessibility,usability
A Cavity-based Microscope for Quantum Gases (CAVITYMICROSCOPE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-05-01
End date: 2017-04-30
Duration (months): 36.0
Total project cost (EUR): 262975.2
EU funding (EUR): 262975.2
Participants: 1
Project status: CLOSED

Exploiting fascinating quantum properties for novel technical applications is appealing but still a dream. However, fundamental understanding of quantum systems and their behavior can be obtained by high-resolution imaging of model systems, such as ultracold quantum gases. The limitations of the current generation of such quantum gas microscopes restrict accessible regimes and applications. The IOF 'CavityMicroscope' will develop a novel microscope, based on sensitive detection of atoms evolving within a high-finesse optical cavity. Within CavityMicroscope the fellow will combine two lines of expertise, which he will acquire in the outgoing and return phase, overcoming current limitations. In the outgoing phase, CavityMicroscope builds upon the exceptional expertise in ultracold gases trapped in high-finesse cavities of Prof. Stamper-Kurn, Berkeley (USA), who is a leading scientist in the field. Designing a cutting-edge experimental setup and implementing cavity-aided imaging techniques will allow for non-destructive imaging, in three dimensions, of a quantum gas with single lattice-site resolution and single-atom sensitivity.This ground-breaking approach to quantum gas microscopy will promote EU research in this field during the return phase with Prof. Widera, Kaiserslautern (GER), who is an outstanding researcher regarding quantum systems and impurities in ultracold gases. Finally, CavityMicroscope will be used to non-destructively study and steer the dynamics of impurities in quantum systems. The complementary expertise of both hosts provides the fellow with a unique possibility to develop a novel research niche, pioneered by CavityMicroscope. In combination with the complementary training, this IOF will help the fellow to obtain scientific maturity and to actively shape research in quantum systems, which is a rapidly emerging field. Thereby, the IOF perfectly consolidates the fellow’s long-term aim to reach an independent research position in science in Europe.

Keywords: ultracold atoms,quantum physics,quantum gas microscope,impurity physics,quantum feedback,cavity,optical lattice
robotICs: do autonomous robots benefit from an Intermittent Control (IC) implementation? (ROBOTICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-04-01
End date: 2016-03-31
Duration (months): 24.0
Total project cost (EUR): 183469.8
EU funding (EUR): 183469.8
Participants: 1
Project status: CLOSED

Robotics is predicted to be the next big step in the digital revolution. Therefore, Europe should keep a globally leading position in this much promising arena. One problem in robotics is that state-of-the-art humanoids still cannot stand ground in environments that we humans easily confront. Our proposal deals with the challenging solution of replicating the adaptability and flexibility of human motor control. Here we propose a specific robotics implementation of our bio-inspired Intermittent Control (IC) model and argue that this is a valuable element missing from current robotic schemes. In tasks such as human standing, the neuro-muscular-skeletal system uses sensory information to regulate its motor output and provide for both stability of important performance variables and flexibility of motor patterns to deal with possible perturbations or secondary tasks. We propose that, fundamentally, this process is one of convergence. We provided experimental evidence showing that balance control in humans is highly consistent with a limiting serial process along a converging single channel which is expressed formally in the IC paradigm. Our general strategy is to investigate and validate the IC model in a staged robotics context (simulation, test bed implementation, validation in existing humanoids). Through the fellowship the field of robotics will be significantly enriched with cross-disciplinary knowledge that is instrumental for the development of human-inspired control architectures. To assess if the design of autonomous robots will beneﬁt from a control architecture including an IC module we will systematically analyse the stability and convergence of the proposed control method. This project will put the applicant in a perfect position to gain specific knowledge and skills to investigate and valorise the innovative ‘robotICs’ concept, which might bring Europe to the next stage of developing marketable bionic robots.

Keywords: robotics,intermittent control,humanoids,control engineering,system identification,refractoriness,autonomous systems,bionics,human movement science,cognitive science,learning and adaptation
Technological use disorders: European cross-cultural longitudinal and experimental studies for Internet and smartphone problem uses (TECH USE DISORDERS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 227800.0
EU funding (EUR): 227800.0
Participants: 1
Project status: CLOSED

This research project consists in study the technological use disorders (based on Internet and smartphone) in European problem users, to estimate prevalence, psychosocial profiles, as well as to ascertain psychological factors involved in the development and maintenance of these disorders. This Marie Curie 2013 proposal covers one overall research with two underlying studies: First study, an online survey for cross-cultural longitudinal study with 10 European countries (in three waves) to estimate the evolution of prevalence and profiles of European citizens who present a problematic Internet and smartphone uses (creating and adapting scales, clinically validated, to both technological problem uses) Second study, users extracted from first wave in Belgium will be invited to laboratory testing to determine psychological factors in these problematic technological uses and participate in focus groups to know their own perception of these maladaptive technological usage patterns The objectives for this project are: 1) to select and adapt scales (in the European languages of countries selected) measuring problem Internet and smartphone uses to conduct a cross-cultural study 2) to estimate the prevalence of problem users within three waves to perform a cross-cultural longitudinal comparison per technology, per users’ categories and per country 3) to look into the perception of excessive and problem technological European users selected by a theoretical qualitative sample strategy through online narratives about their sensations, needs, cognitions and behaviours in relation with the maladaptive use of these technologies 4) to selected Belgium problem and non-problem users of both cyber-disorders to test in the laboratory psychological factors that lead with the self-regulation difficulties of users who presents these addictive symptomatology With a mixed methods approach will be provide results in Europe technological use disorders reinforced for experimental findings.

Keywords: internet addiction,mobile phone problem use,internet gaming use,behavioural addictions,cross-cultural research,follow-up,experiments,quantiative and qualitative methods,mixed methods research