Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative designs, extrapolation, simulation methods and evidence-tools for rare diseases addressing regulatory needs (INVENTS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Maintaining an innovative, sustainable and globally competitive health industry
Action type: Research and Innovation actions
Countries involved: France,Netherlands,Sweden,Germany,Austria,Italy,Czechia,Switzerland,United Kingdom
Call: Modelling and simulation to address regulatory needs in the development of orphan and paediatric medicines (HORIZON-HLTH-2023-IND-06, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 6291427.5
EU funding (EUR): 6198302.5
Participants: 17
Project status: SIGNED

The evaluation of new medicines for rare diseases (RD) including rare paediatric RDs is challenging for several reasons, among which are the small patient sample sizes, heterogeneity of patients and diseases and heterogeneity in disease knowledge. Due to these difficulties, access to effective treatments and the number of treatment options are often limited in RDs. INVENTS aims to provide clinical trial trialists, researchers and regulators with a global framework encompassing methods, workflows and evidence assessment tools to be implemented in orphan and paediatric drug development. Our ambition is to significantly improve the evaluation of evidence and regulatory decision-making through the development and validation of: refined longitudinal model-based diseases trajectories and treatment effect, improved extrapolation models, in silico trials (e.g., virtual patient cohorts), optimised model-based clinical trial designs and evidence synthesis methods. These will be evaluated through simulation studies and tested on extensive data from a range of use cases provided by our industrial partners Roche and Novartis and Real World data (RWD) from RD registry. The INVENTS framework will improve consistency and efficiency of the drug evaluation process for RD by augmenting clinical evidence without compromising its scientific integrity and providing regulators assessment credibility criteria. At the end of this 5 years project, the European industry will be able to exploit novel and improved clinical trial designs, in silico trials and RWD analysis approaches supporting drug development in RD. The European Medicine Agency and European national regulators (including Health Technology Assessment bodies) will be supplied with a general framework allowing better informed decision-making. Most importantly, RD patients will benefit from an increased and faster access to efficacious and safe treatments.

Keywords: model based designs,pharmacokinetic pharmacodynamic models,evidence synthesis,rare diseases,rare paediatric diseases,in silico trials virtual cohorts,model assessment criteria,drug approval
A New Bayesian Foundation for Psychometric Network Modelling (BAYESIAN P-NETS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1499991.0
EU funding (EUR): 1499991.0
Participants: 1
Project status: SIGNED

Network modelling is quickly gaining ground as a promising way to understand psychological phenomena. The rise of network analysis can be observed throughout the psychological sciences but has been particularly influential in psychopathology. While the network modelling literature has been rapidly expanding, methodological innovations struggle to keep pace. Reviews taking stock of the field invariably zoom in on the methodological challenges that network research faces. The absence of a confirmatory scheme, the replicability of network results, and the struggle with population heterogeneity rank firmly among the field's top priorities. These methodological challenges critically impede our understanding of psychological phenomena and the design of effective interventions. This proposal outlines a new research program for psychological network modelling that addresses current methodological challenges. Based on the basic principles of Bayesian inference, I develop a new confirmatory network methodology that uses model-averaging to deliver robust, replicable network results. The new model-averaging approach will be designed for an exhaustive collection of network models and for cross-sectional and longitudinal applications. I will develop new models that are urgently needed--but missing from the current set of networks--and advance solutions for modelling heterogeneous psychological data to complete the new program. The proposed work puts psychological network modelling on a firm methodological foundation. To boost the project's impact, the new methods and models are made available in JASP (jasp-stats.org), a user-friendly, free statistical software package that I co-developed. Armed with an exhaustive set of network models, a confirmatory methodology that delivers replicable results, and their implementation in open-source software, applied researchers can leverage the full potential of psychological network modelling.

Keywords: bayesian model averaging network psychometrics symptom networks
A renewable Power-to-Heat technology to decarbonize heavy industry (Heatrix)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Germany
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2023-12-31
Duration (months): 6.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Heatrix is a young deep-tech climate startup based in Bremen, Germany. Our mission is to competitively replace fossil fuels in energy-intensive industries by converting renewable electricity into storable, process heat up to 1500°C. The Heatrix system combines an innovative high-temperature electric heater, utilizing off-grid solar or wind electricity, with a thermal energy storage to provide continuous high-temperature process heat with zero emissions. Our modular approach, where heater and storage are fitted into standardized container systems, enables rapid deployment and easy integration into existing plants with minimal retrofitting requirements. We combine cutting-edge scientific findings with mature technologies and equipment to benefit from economies of scale. Customers can implement Heatrix in a phased approach in line with market demand for green products and the availability of renewable electricity. Given the complexities of our technology and the challenges to build a successful startup supporting programmes such as the Woman TechEU are invaluable. The grant will allow us to build more confidence towards our technology for future customers. We plan to use the grant to attract industry partners and strengthen our relationships by collaborating on first feasibility studies to evaluate integration possibilities of the Heatrix system in existing processes. Moreover, the support of experienced mentors and coaches will help us to sharpen our business plan, secure initial customers as well as build and grow high-performance teams. Gender equality is a matter of course to us and especially for me, female CEO and founder of Heatrix, a heartfelt wish. I am eager to get in touch and learn from successful female role-models to strengthen my team-building capacities and leadership skills.

Keywords: climate tech,high temperature process heat,renewable energy,decarbonizing heavy industry
Financial Education in the Workplace: Combining Experimental Evidence with Administrative Data (FINANCEforALL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Portugal
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2498000.0
EU funding (EUR): 2498000.0
Participants: 1
Project status: SIGNED

Understanding and managing personal finances is crucial for promoting individuals’ financial and economic well-being. Yet, financial literacy remains low globally, with only one-third of people understanding basic financial concepts. In addition, socioeconomic and gender financial literacy gaps persist, exacerbating social inequalities. Increased complexity of financial markets and personal responsibility due to longer life expectancy, the emergence of private pension plans, and the digitalization of banking underscore the need for national strategies to promote financial literacy. Those can empower individuals, enhance financial stability, and promote inclusive economic development. FINforALL will evaluate the impact of a large-scale financial literacy intervention on the working population in Portugal, a developed country with below-average financial literacy. It investigates how financial education shapes individuals’ financial knowledge and behavior and how these effects extend to co-workers, firms, and local economies. While financial literacy programs have been studied globally, this project analyses often-overlooked spillover effects, which are important to designing cost-effective interventions. The experimental design involves three randomization units: municipalities, firms, and employees. It combines survey data collected during the experiment with unique administrative data at the individual level (credit registry, tax filings, property registry, and private banks’ transactions) and firm-level (financial statements and matched employee-employer). These data allow me to examine the short- and long-term effects on individual outcomes, such as assets, credit, income, consumption, saving, employment, entrepreneurship, and broader effects on firms and local economies. FINforALL will be the first to examine the direct and spillover effects of financial education at the workplace, offering new insights into its broader implications of financial education.

Keywords: financial education financial literacy financial decisions rct firms local economies economic growth
Medieval Appetites: food plants in multicultural Iberia (500-1100 CE) (MEDAPP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Spain,Portugal
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2498845.0
EU funding (EUR): 2498845.0
Participants: 4
Project status: SIGNED

The Islamic conquest of Iberia in the 8th century brought in profound changes in the political, social and economic realms that transformed the everyday life of local rural and urban communities. Technological innovations and the arrival of new crops impacted their agriculture, diet and culinary practices. Plants were present in almost all aspects of medieval people’s ordinary lives (food, crafts, medicines, etc.). However, they have been commonly sidelined in discussions of the past. Most of what we know about plants in this multicultural period in Iberia is based on a limited number of archaeobotanical studies and on written sources, which despite their undeniable value they often reflect issues related to the elites. By contrast, archaeology, and more specifically archaeobotany and their associated science-based techniques, are placed in an extraordinary position for approaching issues related to plant production, processing, preparation and consumption, and how these connect to broader societal changes. By integrating archaeobotany and written sources, as well as applying ground-breaking techniques (plant genomics and food remains analyses), MEDAPP aims to disentangle what range of plants were used in Medieval Iberia (6th-11th CE); where new species came from and when were they introduced, who brought them, and how people engaged with them through different practices. The project sets a new holistic agenda for understanding the impact of the new political, economic and social system on agriculture, eating habits and culinary practices of Iberian medieval communities. This project aims at providing a step-change in the way agriculture, plant production, preparation and consumption have been studied in Medieval Iberia. It represents a golden opportunity to fill the voids of texts, looking for clues in the archaeobotanical record; an occasion to approach, with a suite of scientific and innovative methods, the unspoken information contained in these silences.

Keywords: archaeobotany,written sources,islamic,food,identity,storage,food remains,isotopes,genetics,
Posture and bodily movements in the Bible and biblical religions (POSTURE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Holy See (Vatican City State),Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2025-07-31
Duration (months): 38.0
Total project cost (EUR): 266152.49
EU funding (EUR): 266152.49
Participants: 3
Project status: SIGNED

Postures and movements are relevant for both a linguistic and a socio-anthropological investigation. From a cross-linguistic perspective, verbs of posture and motion show several interesting idiomatic and metaphorical usages, and can be employed to express abstract concepts (e.g., psychological states) and grammatical aspects (e.g., urgency or gradual progression of an action). From a socio-anthropological perspective, posture and body language can express real or assumed power relationships and hierarchies, and serve as “externalizers” of status, gender, age, and physical weakness. They establish, express, and maintain group identity; and they indicate friendship and respect or, on the contrary, hostility and self-protection. POSTURE investigates the theme of bodily attitudes, postures and movements within one of the most important pieces of cultural heritage, the Old Testament (OT). Furthermore, it also investigates the reception of Biblical postures and motions within cultural and intellectual products that depend on the OT, either directly or indirectly, i.e., ancient translations (Aramaic, Syriac, Greek and Latin) and Late Antique Jewish and Christian exegesis (1st-3rd c. CE). Descriptions of bodily postures and motions are very recurrent in the OT, both literally and metaphorically. However, as of today, not enough attention has been paid to this topic. Combining the semantic analysis of posture and motion verbs with their anthropological and social implications will allow to gain new knowledge about the idea of body in the OT. Moreover, the analysis of reception in early exegetical Jewish and Christian contexts will shed some light on the development of the meaning of body and bodily attitudes, through centuries of translations and theological interpretations, from ancient times to present days.

Keywords: posture and movement,old testament,semantics,classical hebrew,other biblical languages greek,latin,syriac,aramaic,ancient biblical versions,jewish and christian exegesis
The one-stop-shop of accessible circular solutions for sustainable tourism (VERNE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Innovation actions
Countries involved: Spain,Greece,Italy,Türkiye,Ireland,Slovenia,Denmark,Germany,Finland,Austria,Sweden
Call: Systemic circular solutions for a sustainable tourism (HORIZON-CL6-2024-CIRCBIO-01, 2024)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 5332978.75
EU funding (EUR): 4985111.13
Participants: 16
Project status: SIGNED

The European tourism sector plays a pivotal role in driving economic growth, employment, and social development. However, it faces challenges deriving from its predominant reliance on linear models, causing significant environmental impacts and resource depletion. Recognizing the necessity for a paradigm shift, the VERNE project aspires to accelerate the transition of local and regional tourist destinations toward sustainable and circular models across Europe. VERNE aims to provide an integrated framework for analysing the feasibility and impact of circular interventions in tourism destinations, offering recommendations for authorities, tourism industries, and citizens for the sector's transition into more sustainable business models. In collaboration with public administrations, DMOs, private sector services, industries, citizens and tourists, NGOs, and other stakeholders, VERNE will create and validate a range of systemic, replicable, and scalable solutions, tailored on the real needs and attitudes of these actors. These solutions will encompass diverse approaches and technologies (i.e., digital solutions, improved waste and food waste management, wastewater treatment, use of electric vehicles, etc.) and will cover several sector and services for tourism . The VERNE solutions will be implemented and demonstrated in 5 European representative tourist destinations (VERNE Pilots). The project's outcomes will be incorporated into new business models, providing a quantified demonstration of their effects on the competitiveness and sustainability of existing tourism services. Finally, VERNE will have the ambition to emerge as one-stop-shop for sustainable tourism, serving as a comprehensive hub of expertise, tools, and best practices on sustainable tourism, facilitating the adoption and replication of circular systemic solutions across Europe.

Keywords: systemic solutions,sustainable business models,circular economy in tourism
Demystifying the impact of HIV-antiretroviral therapy on fertility and the epigenome of gametes and early embryos (EpiHIVgametesembryos)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 1
Project status: SIGNED

HIV (Human immunodeficiency virus) is a global epidemic that led to the death of over 40.1 million persons since its first report. Currently, about 38.4 million people are living with HIV (PLHV) globally; 1.9 million in Nigeria. The introduction of combination antiretroviral therapy (cART) has improved the lifespan of PLHV making it a chronic disease, yet in 2021 about 650,000 persons died from HIV-related illnesses. Efforts are being made to scale up treatment access to cART to reduce mortality. However, in recent years, a not well-understood decline in fertility of PLHV undergoing cART is a great concern for HIV treatment. Recent studies detected epigenetic abnormalities in the blood of PLHV undergoing cART with global changes in DNA methylation, where it is unclear if cART or HIV itself could be the cause. Abnormal establishment of DNA methylation in the gametes can lead to the manifestation of epimutations in the growing embryo with potentially bad consequences like embryo loss, diseases, and cancerogenesis. This study aims to determine the impact of cART on fertility and on the DNA methylome in gametes and derived embryos in the mouse as a model system. It will involve the analysis of DNA methylation changes in spermatozoa and oocytes, derived embryos, and offspring, as well as the examination of embryonic genome activation in 2-cell embryos and successful blastocyst development in early embryogenesis of mice under cART. This study will contribute to health education about HIV and its treatment, boosting the reproductive health of PLHV and, importantly, improving their compliance with antiretroviral therapy - thereby aiding the achievement of the UNAIDS target of 2030. Furthermore, It will foster the mutual transfer of expertise in andrology and HIV-biology to the host institution and will equip the applicant with novel skills in epigenetics and assisted reproduction, relevant soft skills, and new collaborations for his career development.

Keywords: human immunodeficiency virus hiv,combination antiretroviral therapy cart,lamivudine,tenofovir,dolutegravir,dna methylation,fertility
Centre of Excellence in exascale-oriented application co-design and delivery for multiscale simulations (MultiXscale)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Research and Innovation actions
Partnership: EUROHPC (JU-JTI)
Countries involved: Slovenia,Germany,Spain,Netherlands,Belgium,Norway,Italy,France
Call: Centres of Excellence for supporting supercomputing applications for Science and Innovation (HORIZON-EUROHPC-JU-2021-COE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 5981112.5
EU funding (EUR): 2990555.78
Participants: 17
Project status: SIGNED

The MultiXscale Centre of Excellence will increase performance, productivity and portability (“the Three P's”) across the entire spectrum of scientists active in the domain of multiscale simulation. It couples the scientific expertise of the CECAM network, represented by leading experts in multiscale simulations from different European institutions, with the technical expertise of the EESSI collaboration, and targets the computational laboratories of EuroHPC and beyond. It will shoulder much of the technical burden of developing and distributing domain-relevant applications for (pre-)exascale through application co-design for exascale technologies, and the provisioning of exascale-oriented libraries and services that nudge the community to adopt battle-tested, future-oriented, scalable workflows and portable technologies. Together, these will allow application developers to pursue domain-relevant scientific innovation without being over-burdened by technical detail, and empower industrial and academic application users to painlessly adopt bleeding-edge technologies from the domain on whatever computational resource they may have access to. To drive the development of the libraries and services, and to showcase the scientific and industrial potential of truly multiscale approaches, MultiXscale will pursue three pilot use cases of societal and industrial significance: · helicopter design and certification for civil transport, · battery applications to support the sustainable energy transition, · ultrasound for non-invasive diagnostics and biomedical applications. MultiXscale will extend the applications, user-base and domains actively engaged in the current CoE and EuroHPC ecosystem by addressing specific and critical needs, and advancing the transition towards use of exascale resources by scientific and industrial users in the community of multiscale modelling.

Keywords: multiscale processes,materials modelling,biophysics,application deployment