Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Scale up user-Centric and dAta driven soLutions for connEcted Urban Poles (SCALE-UP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Countries involved: Spain,Germany,Spain,Spain,Belgium,Finland,Belgium,Belgium,Belgium,Netherlands
Call: Cities as climate-resilient, connected multimodal nodes for smart and clean mobility: new approaches towards demonstrating and testing innovative solutions (H2020-MG-2020-TwoStages, 2020)
Start date: 2021-06-01
End date: 2025-05-31
Duration (months): 48.0
Total project cost (EUR): 10388309.38
EU funding (EUR): 8946502.39
Participants: 24
Project status: SIGNED

In SCALE-UP 3 advanced urban nodes Antwerp, Madrid and Turku, team up around 1 main goal: develop data-driven and user centric strategies to accelerate the take-up of smart, clean and inclusive mobility, by means of well-connected and multi-usage urban nodes, to the level needed to meet EU climate and transport objectives. To reach the main goal, 5 strategic objectives are defined: - Improve multi-level and multi-stakeholder governance enabling seamless multimodal transport across urban nodes - Develop (inter)connected and multimodal nodes for passengers and freight as a backbone of a resilient mobility system, including network optimisations -Develop data driven mobility strategies and tools to stimulate seamless multimodal transport of passengers and freight and optimise network capacity across the wider urban area - Provide access to inclusive clean and safe mobility solutions - Change travel behaviour focussing on clean, active and healthy modes of transport The 5 objectives relate to fields of intervention in which the SCALE-UP urban areas excel and deliver valuable output by implementing 28 mobility measures scaled to the FUA and taking into account the TEN-T dimension. Furthermore a strong framework for thematic policy validation amongst SCALE-UP experts guarantees a meaningful cooperation between the 3 urban areas, internal capacity building and mutual exchange and learning. A 6th strategic objective (TAKE UP) defines how the project delivers evidence of the effectiveness of the different actions in relation to EU climate and transport targets, and how it accelerates the take-up of these solutions amongst and beyond SCALE-UP urban areas. The evaluation framework with proven EU record, provides evidence of the impact. Moreover the data driven approach pays special attention to how new digital mobility solutions yield new datasets. These offer new insights and feed the evaluation framework resulting in a more evidence- based policy development.

Keywords: scale up,data driven,user centric,multimodal hubs,behavioural change,governance,clean mobility,safety,take up,evaluation,vunerable user groups
Three-Dimensional Mapping Of a Single Hydrogen Bond (3DMOSHBOND)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2025-03-31
Duration (months): 87.0
Total project cost (EUR): 1971468.0
EU funding (EUR): 1971468.0
Participants: 2
Project status: SIGNED

All properties of matter are ultimately governed by the forces between single atoms, but our knowledge of interatomic, and intermolecular, potentials is often derived indirectly. In 3DMOSHBOND, I outline a program of work designed to create a paradigm shift in the direct measurement of complex interatomic potentials via a fundamental reimagining of how atomic resolution imaging, and force measurement, techniques are applied. To provide a clear proof of principle demonstration of the power of this concept, I propose to map the strength, shape and extent of single hydrogen bonding (H-bonding) interactions in 3D with sub-Angstrom precision. H-bonding is a key component governing intermolecular interactions, particularly for biologically important molecules. Despite its critical importance, H-bonding is relatively poorly understood, and the IUPAC definition of the H-bond was changed as recently as 2011- highlighting the relevance of a new means to engage with these fundamental interactions. Hitherto unprecedented resolution and accuracy will be achieved via a creation of a novel layer of vertically oriented H-bonding molecules, functionalisation of the tip of a scanning probe microscope with a single complementary H-bonding molecule, and by complete characterisation of the position of all atoms in the junction. This will place two H-bonding groups “end on” and map the extent, and magnitude, of the H-bond with sub-Angstrom precision for a variety of systems. This investigation of the H-bond will present us with an unparalleled level of information regarding its properties. Experimental results will be compared with ab initio density functional theory (DFT) simulations, to investigate the extent to which state-of-the-art simulations are able to reproduce the behaviour of the H-bonding interaction. The project will create a new generalised probe for the study of single atomic and molecular interactions.
Chiroptical, optical and magnetic probes for protein sensing based on cage metal complexes (CLATHROPROBES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria,Germany,Ukraine,Russian Federation,Moldova, Republic of,Romania,Poland
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 855000.0
EU funding (EUR): 796500.0
Participants: 8
Project status: SIGNED

The CLATHROPROBES project is devoted to the design and development of novel, highly efficient chiroptical, luminescent, IR, NMR and EPR probes for sensing and structural studies of biomolecules based on cage metal complexes (clathrochelates and lacunar complexes of spatial tris-diiminate ligands with encapsulated 3d-metal ion) as molecular reporters. For successful design and synthesis of cage metal complexes (WP1), their complete structural and spectroscopic characterization (WP2), studies of their interactions with biomolecules and reporting properties, and their cytotoxicity and bioactivity in model systems (WP3), the project brings together researchers from four academic institutions and two industrial companies, representing six countries (PL, DE, UA, RO and AU; RU - participation till April 8th, 2022). The participants will contribute to the project with different, highly specific, yet complementary expertise, namely in chemical synthesis of clathrochelate complexes (PBMR and FAU; INEOS RAS participation till April 8th, 2022), identification and structural studies of compounds and materials (PBMR, FAU, UWR, UNIVIE, and SPS; INEOS RAS - participation till April 8th, 2022), characterization of interactions between ligands/clathrochelates/materials and biomolecules by CD, UV-VIS, fluorescence ITC, IR, NMR methodology (UWR, FAU, PBMR, UNIVIE, SPS), and biological studies (FAU). Joint efforts of participants of this multidisciplinary project will provide - the transfer of knowledge between scientists of different research areas, sectors and countries that will enhance level of their professional scientific/technical expertise, -training of young researchers, very important for their further scientific success or industrial career, - enhancement of research activity and network of participating Institutions, - new long-term collaborations between the partners, - increase of academia-industry interactions, so valuable for innovative ideas and discoveries, and pair scientific excellence with social awareness and understanding of current tasks and problems of science.

Keywords: clathrochelates,cage metal complexes,proteins,albumins,detection,probes,synthesis,spectroscopic techniques,circular dichroism,fluorescence
Structural dynamics essential for photosynthetic adaptation and survival of cyanobacteria in fluctuating light intensities (OCPSTRUCTDYNAMICS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-08
End date: 2022-01-07
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Like most photosynthetic organisms, cyanobacteria are vulnerable to fluctuations in light intensity, which can damage their photosynthetic machinery. To protect themselves against such fluctuations, they use a photoprotective mechanism called non-photochemical quenching (NPQ), i.e. the dissipation of excess absorbed photo-energy as heat. NPQ in cyanobacteria is triggered by orange carotenoid protein (OCP) light activation. Based on spectroscopic and diffraction studies of OCP in Synechocystis 6803 (gene slr1963), it was suggested that OCP light activation occurs through light-induced movement of a carotenoid causing movement and/or dissociation of OCP N- and C-terminal domains. However, the exact structural dynamics of OCP light-activation need to be unravelled. Furthermore, the growing availability of cyanobacterial genomes allowed identification of additional OCP subfamilies (OCP2, OCPX) in different cyanobacteria. The first results demonstrating different kinetics of light-activation in the different OCP paralogs raised questions about differences in their photoprotective roles and in photoactivation mechanisms. This topic has not been studied to date. Here I propose to resolve structural changes during photoprotection-related transitions of OCP in different OCP subfamilies using time-resolved X-ray crystallography. X-ray crystallography of OCP1 encoded by slr1963, the best-characterized OCP protein, as well as its paralogs from the OCP2 and OCPX subfamilies will be performed. This approach will be combined with ultrafast transient (polarised) absorption spectroscopy on isolated proteins and oriented single crystals to describe the structure-dependent flow of photoenergy in the proteins. This study has several potential applications ranging from enhancing cyanobacterial light harvesting to improve biofuel production, to better understanding of carotenoid-protein interactions in artificial photosynthesis systems, and for optogenetics.

Keywords: orange carotenoid protein,non photochemical quenching,photosynthesis,cyanobacteria
Radiocarbon, tree rings, and solar variability provide the accurate time scale for human evolution and geoscience (RESOLUTION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Germany,Italy,Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-06-01
End date: 2024-12-31
Duration (months): 67.0
Total project cost (EUR): 1499381.0
EU funding (EUR): 1149476.0
Participants: 3
Project status: SIGNED

Europe was the continent where Neanderthal and Anatomically Modern Human (AMH) interacted in a supposed time window of up to five millennia around 40,000 years ago (40 ka BP). The fate of our species versus the demise of Neanderthals, the geospatial timing of this process, the behavioural implications of their interaction, are hotly debated topics in archaeology. In this context, chronology plays a pivotal role, with radiocarbon (14C) dating representing the backbone back to 50 ka BP. However, due to varying atmospheric 14C concentrations in the past, the method requires calibration to an independently dated archive. So far, only the past 14 ka BP can profit from the most direct natural archive of 14C activity, which are annually resolved tree-ring chronologies. Before this time, temporal resolution is remarkably lower and different calibration records disagree, leading to discrepancies in the calibration of up to 2000 years. This project aims to achieve for the first time an accurate and highly resolved chronology back to 50 ka BP, to establish the timing of when AMHs arrived in Europe, their interaction with Neanderthals and the final cause of Neanderthal extinction. The project involves fieldwork in Mediterranean and southeast Europe to find more glacial trees, the study of the existing collection of glacial conifers, exceptional 14C precision for 14C dates in the Glacial, and the cutting-edge methodology in linking floating tree-ring chronologies to 10Be on the ice core scale. The results of this work will be crucial in solving some of the most interesting puzzles in European prehistory. With tree-rings, the resolution will be an order of magnitude higher, and using the most recent advances in the AMS technique, we will obtain confidence intervals of only a few centuries in glacial times. This project will be of pivotal importance for key periods in human evolution.

Keywords: human evolution,radiocarbon dating,dendrochronology,cosmogenic isotope,neanderthal,anatomically modern human
Learning the Language of Belonging: Barriers to Inclusion in Refugee Education (LearningtoBelong)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Türkiye
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-05
End date: 2023-07-04
Duration (months): 24.0
Total project cost (EUR): 157355.52
EU funding (EUR): 157355.52
Participants: 1
Project status: SIGNED

Public education creates places for children in the future of a society. This is what the United Nations Refugee Agency intends by promoting the inclusion of refugee children into national education systems in countries of first asylum. However, everyday schooling experiences of refugee children exemplify that education presents less a magic portal to social inclusion than a site of continuous struggle over legitimate membership and equal opportunity. The proposed project aims to better understand the barriers to social inclusion in public schooling by examining how language preparatory classes socialize refugee students and their caregivers. While becoming proficient in the official language of the host country is understood to be a prerequisite for both educational and social inclusion, language learning is not a simple matter of an acquisition of a new skill. Rather, language learning constitutes a power-laden process, which introduces learners to broader social hierarchies. Accordingly, the proposed project seeks (i) to acquire new knowledge on how language preparatory classes frame conditions of social acceptance and how refugee communities respond to such educational measures, (ii) to contribute to the global discussion on barriers to social inclusion within refugee education while informing policymaking on a national scale in the country where it takes place, and (iii) to develop a collaborative and empowering research methodology when working with refugees. For this purpose, the study will employ a participatory action research methodology, which is based not only on inviting refugee caregivers to become active investigators of the study but also on developing a university-community partnership. The fellowship will support the researcher’s career development by expanding her methodological skills, improving her networking and cooperation skills, and building her capacity for higher social impact.

Keywords: language preparatory classes,participatory action research,parent involvement in refugee education
Prevention of injuries to patients and nurses due to intravenous line dislodgement (ReLink)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-09-01
End date: 2023-04-30
Duration (months): 32.0
Total project cost (EUR): 2485758.75
EU funding (EUR): 1740030.0
Participants: 1
Project status: CLOSED

Intravenous (IV) therapy is the channelling of medicine and blood directly into a patient’s venous system using a plastic tube. With 3.8 billion tubes used per year, it is the most performed invasive treatment in Europe and USA. However, up to 36% of all these treatments are interrupted by an accidental pull to the tube, costing healthcare an annual €28.3 billion. When this happens, the patient will get hurt and blood and medicine will be spilled. It takes a nurse on average 30 minutes to tend to the patient, clean the spill and reinstate therapy. And when doing so, the nurse puts him or herself at risk for being exposed to contaminated blood and toxic medication such as chemotherapy. There global nursing shortage will worsen with population ageing, IV dislodgement does not help this situation. What can help is the ReLink safety connector. ReLink is an award-winning, patented technology which is low cost to produce, intuitive to use, and have the potential to create a new annual market worth €11.4 billion in Europe and USA. The objective for the proposed project is to grow ReLink from its current prototype phase to a market ready product. This involves product development to frozen design (WP 1), regulatory activities to secure clinical evidence, ISO certificate, CE mark and apply for FDA approval (WP 2), intellectual property related activities (WP 3), as well as market surveillance and networking to secure the supply chain, prepare for post-project investments and support from future customers (WP 4) and project management and growing the team (WP 5). Tada Group’s business model is to focus on R&D and marketing. Our core competence is need based product development and evidence based medtech marketing. Production and sales will be done by strategic partners, thus keeping cost of goods low as sales increase. ReLink prevents dislodgement, we will reshape the IV landscape and save lives. Will you join our quest? Join Tada!

Keywords: healthcare,patient safety,work environment safety,intravenous iv therapy,need based,safety connector,nurses,toxic medication,accidental dislodgement,personnel safety,pediatric,oncology
Responsible Neuro-Technologies of Pain: Understanding Vulnerability in Pain Care with Minimally and Non-Invasive Neuro-Technologies for Pain Modulation in the United States (REGAIN) (REGAIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2024-09-30
Duration (months): 36.0
Total project cost (EUR): 246669.12
EU funding (EUR): 246669.12
Participants: 2
Project status: TERMINATED

Chronic pain is a global health challenge of enormous proportions. Estimates claim that over 1.5 billion people live with chronic pain worldwide, which results in $245 billion USD in global economic costs annually. Recently, minimally and non-invasive neuro-technologies for pain modulation promise to provide a new avenue to support people living with chronic pain. Especially in the United States (U.S.), pain modulation has gained attention as a low-risk alternative to pain treatment with addictive opioids. However, I hypothesise that the use of these neuro-technologies will produce new vulnerabilities for consumers, Do-It-Yourself (DIY) users as well as clinical patients. To date, there is a lack of understanding and an urgent need for anticipating these vulnerabilities in order to render neuro-technology a responsible contribution to the health challenge of chronic pain in Europe. Within the proposed project, I will study the socio-political context and actual use of neuro-technologies in pain care in the context of the U.S. I will transfer the resulting insights and learned lessons to relevant stakeholders in the study, design, and governance of pain modulation in Europe. The overall aim of REGAIN is to provide an integrative framework for studying, designing, and governing “Responsible Neuro-Technologies of Pain” (NTPs). I ground this framework in an extensive qualitative study of (a) the socio-political context of neuro-technology in pain care across the U.S. and Europe as well as (b) the user practices in consumer, DIY, and clinical pain care with minimally and non-invasive NTPs in the U.S.

Keywords: social study of neuroscience,vulnerability,user research,anthropology of chronic pain,disability studies
Brain-speech tracking in noisy conditions: towards the identification and remediation of dyslexia. (DysTrack)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

Dyslexia is a developmental disorder leading to reading difficulties. It affects 5–12 % of children and young adults. Unfortunately, we still lack efficient and cost effective methods to identify and remedy this disorder. Dyslexia appears to be frequently linked to hindered phonological processing at the cortical level, with drastic consequences in the presence of noise. The overarching goal of this project is to better understand cortical speech processing in the presence of noise, in order to provide novel identification and remediation methods for dyslexia. Magnetoencephalography and electroencephalography studies have uncovered the phenomenon of brain-speech tracking, that is, the tracking of continuous speech sounds by cortical activity. This tracking is suggested to reflect speech sound chunking and parsing mechanisms, and is altered in dyslexic readers. Importantly, it can be used to evaluate brain capacity to track a sound stream of interest in the presence of noise. Given that individuals’ capabilities to discriminate speech in noisy conditions improve until age ~12, we propose, as a first step, to characterize brain-speech tracking in the presence of noise 1) across the normal development and 2) in children with dyslexia. To modulate task difficulty, we will use several types of noise (from white noise to babble), with or without visual information of the speaker’s lip movements. We will then attempt to predict subjects’ reading skills based on their brain-speech tracking parameters (i.e. their fingerprint of brain-speech tracking capabilities). Finally, we will evaluate whether neurofeedback sessions can sustainably boost brain-speech tracking. These developments are instrumental to the realization of future studies intended to restore the integrity of brain-speech tracking capabilities, with the aim of alleviating the reading deficits of dyslexic readers.

Keywords: dyslexia,speech in noise,neurofeedback