Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
New Windows onto the Sun: Probing the Sun’s magnetic field with an array of new missions and observatories (WINSUN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2498750.0
EU funding (EUR): 2498750.0
Participants: 1
Project status: SIGNED

The Sun provides the energy necessary to sustain life on Earth, making it a star of unique importance for human society. It is also the only star whose surface we can resolve to reveal the richness of the complex processes acting there, creating a highly dynamic and varied environment. Much of the structure and dynamics visible on the Sun is caused by the intricately structured magnetic field and its interaction with the turbulent plasma. However, there are considerable gaps in our knowledge of the fundamental physical processes driving the evolution of the solar magnetic field, from its generation to its removal from the solar surface, and how the field drives solar activity and variability. To fill these gaps, this project will make use of powerful new observational missions and facilities: Solar Orbiter, Sunrise III, Daniel K. Inouye Solar Telescope (DKIST) and Aditya-L1, which will open new windows onto the Sun and its magnetic field. They will provide the first clear views of the solar poles (Solar Orbiter), and the highest spatial resolution ever in the Extreme Ultraviolet (Solar Orbiter) and in the visible (DKIST). They will also explore a new spectral window onto the solar photosphere and chromosphere (Sunrise III, Aditya-L1). The advanced instrumentation, complemented by novel data analysis techniques and state-of-the-art magneto-hydrodynamic simulations, will allow tackling, often in entirely new ways, long-standing difficult problems that have resisted previous attempts at resolving them. Elucidating these will provide deep insights into the life cycle of the magnetic field, and how it affects the Sun’s atmosphere and variability. A decade’s efforts by me and my group has positioned us at the core of the new instrumentation, data analysis techniques and simulations, making us very well placed to apply the exciting data from the new resources to unravelling the fundamental physics driving the evolution of the Sun’s magnetic field.

Keywords: solar magnetic field,solar activity,solar variability,solar atmosphere
Industry empowerment to Multiphase fluid dynamics simulations using Artificial intelligence and Statistical methods on modern hardware architectures at Scale (SCALE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Austria,Netherlands,Sweden,Greece,Belgium,United Kingdom
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-10-01
End date: 2028-03-31
Duration (months): 54.0
Total project cost (EUR): 2750991.43
EU funding (EUR): 2635135.2
Participants: 17
Project status: SIGNED

Multi-phase, trans/supercritical and non-Newtonian fluid flows with heat and mass transfer are critical in enhancing the performance of energy production, propulsion and biomedical systems. Examples include: hydraulic turbomachines, ship propellers, CO2-neutral e-fuels and e-motor cooling systems, particle-laden flows in inhalers and focused ultrasounds for drug delivery. What all these cases have in common is the high level of complexity which makes Direct Numerical Simulations impossible. State-of-the-art LES simulations rely on simplified assumptions but do not have yet the desired accuracy, while often require enormously expensive CPU resources. The aim of SCALE is to develop simulation methods and reduced-order models using physics-informed and data-driven Machine Learning and optimisation methods for such flow processes. These will be trained against ‘ground-truth’ databases that will be generated for the first time using both DNS and experimentally validated, industry-relevant LES and multi-fidelity RANS simulations. The new simulation tools will be applied for the first time to industrial problems and their ability to accelerate design times and improve accuracy will be jointly pursued and evaluated with the non-academic partners of SCALE. These are international corporations and market leaders in the aforementioned areas. Holistic training by experts from science and industry includes broad reviews on relevant scientific topics, modern high performance computing architectures suitable for performing such simulations, big data analytics as well as extensive support for mastering scientific tasks and transferring the knowledge acquired to industrial practice. SCALE will also deliver soft skills training from a well-connected cohort of leaders with the ability to communicate across disciplines and within the general public. This coupling of research with industry makes SCALE a truly outstanding network for doctoral candidates to start their career.

Keywords: two phase flows,cavitation,cfd,machine learning
Smart, Aware, Integrated Wind Farm Control Interacting with Digital Twins (ICONIC) (ICONIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Norway,Denmark,Belgium,Switzerland,United Kingdom,Spain,Netherlands
Call: Integrated wind farm control (HORIZON-CL5-2022-D3-03, 2022)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 3897447.51
EU funding (EUR): 3897447.5
Participants: 16
Project status: SIGNED

ICONIC aims to develop innovative physical and digital tools to achieve fundamental breakthroughs for the integrated control of wind farms, considering the whole physical system at farm, turbine, and component levels, in particular the complex aerodynamic interactions among turbines. ICONIC aims to increase farm-wide power production by 15-20% under optimal wind speeds and directions for typical wind farms suffering from wake effects, with a 3%-5% increase in annual energy production (AEP) considering all working conditions over the long term. It targets an LCOE reduction of at least 6% compared with the state-of-the-art control tools deployed in the current wind industry by improving farm-wide AEP and reducing operation & maintenance costs via leveraging the latest AI and digital technologies. Extensive validations for the integrated wind farm control solutions will be conducted via high-fidelity simulation models, experiments at a national-level wind tunnel, historical operational data at BP’s and C-Power’s wind farms, a unique collection of test rigs for critical turbine components at respective companies, and real-world wind farm field tests at C-Power. ICONIC’s integrated wind farm control system will contain (1) novel AI-based wind farm control system to unlock wind farms’ full potential; (2) novel data-enhanced wind turbine controllers to fulfil farm-level commands while balancing power generation and load mitigation; (3) an integration with digital twins (DTs) as extra support to improve control and reduce costs, which contains a first-ever farm-level DT for wind farm flow systems replicating detailed physical flow fields and an innovative turbine-level DT with critical component models for loading and lifetime estimations; (4) extensions of the solutions to future 20MW turbines. ICONIC will establish new knowledge and industrial leadership in key digital, enabling and emerging technologies, and deliver next-generation tools for wind farm operation.

Keywords: wind farm control,artificial intelligence,digital twin,reinforcement learning,data driven tool
Unlocking Fe(II)/αKG-dioxygenase enzymes as sustainable biocatalysts for the synthesis of isonitriles (BioIson)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Isonitriles are valuable organic molecules endowed with unique reactivity features, which find wide applications in a variety of chemical fields, from material sciences to chemical biology, organic, and medicinal chemistry. Current methods to prepare isonitriles suffer from major drawbacks in terms of safety and sustainability, as they rely on the use of large amounts of highly toxic chemicals (e.g., COCl2, POCl3, TMSCN), which make their synthesis hazardous and wasteful, especially for industrial-scale production. Based on the established ability of biocatalytic strategies to enable milder, greener, and more selective chemical processes, the aim of this project is to investigate, characterise, and engineer the protein ScoE from Streptomyces coeruleorubidus and related isonitrile-forming enzymes from the Fe(II)/αKG-dioxygenase superfamily with the final goal to turn them into a new class of biocatalysts for the sustainable production of isonitrile compounds. The project will first characterise wild-type ScoE in order to optimise the biotransformation parameters and to evaluate the in vitro catalytic performances of the enzyme and its natural substrate scope (specificity and selectivity). In parallel, representative isonitrile-forming Fe(II)/αKG-dioxygenases with potential for different activity and selectivity will be selected from assorted environmental niches and assessed for their substrate flexibility and their ability to biocatalyse the synthesis of isonitrile derivatives in vitro. Such investigations will provide experimental data to drive the identification of best candidates for biocatalyst development. Mutagenesis studies driven by in-silico design will be performed to generate improved Fe(II)/αKG-dioxygenase variants (with broader substrate scope) to be exploited as biocatalysts. The hit enzymes will be produced on larger scale and biocatalytic methods for the preparative synthesis of isonitriles will be developed.

Keywords: biocatalysis,isonitrile
LiWeFor: Living labs for Wetland Forest research (LiWeFoR)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Estonia,Germany,Finland
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 1499406.0
EU funding (EUR): 1499406.0
Participants: 3
Project status: SIGNED

The main aim of the LiWeFor is to establish and develop a global network of Living Labs of wetland forest research, education and management. The project team consists of the University of Helsinki and Karlsruhe Institute of Technology as top-class research counterparts and the University of Tartu as the recipient. As a driving vehicle of the project, four joint field campaigns to global greenhouse gas emission hotspots in tropical wetland forest regions (Peru and Malaysia) will enforce educational knowledge transfer. In addition to training, this exploratory research component binds together other activities from all partners. It will also serve as a proof-of-concept for testing the virtual framework of LLs that will enable hybrid formats of skills transfer, teaching and training on remote. LiWeFor - a research and education project - addresses the need to systematically raise the level of expertise among researchers and decision-makers in the widening country of Estonia. The Twinning partnership project will bring expertise from countries with top-level forest ecosystem research - Germany and Finland, particularly focusing on enhancing career awareness, enabling a capable workforce, and on promoting science-related careers. The major outcome will be a network of Living Labs of wetland forest research and education. A major focus is put on 1) closing the knowledge and experience gap between the donor and recipient partners, 2) building carbon and nutrient management strategies for temperate and tropical wetland forests involving stakeholders and policymakers, 3) creating an open data repository of GHG measurements and environmental factors in wetland forests, 4) constructing a basis for global spread of the Living Labs network of wetland forest research and education.

Keywords: wetland forests,tropical swamps,greenhouse gases,soil microbiome,nitrogen and carbon isotopes
Resolve human autoantigen-specific regulatory T cell responses (ReSpecTreg)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Antigen-specificity is the key feature of adaptive immunity, orchestrated by CD4 T helper (Th) cells. A small CD4+ subset of autoreactive Foxp3+ regulatory T cells (Tregs) secures tolerance against self and contributes to tissue homeostasis and regeneration. It is a central question in immunology how Tregs exert these various functions. In humans, however, self-specific Treg and Th cells are challenging to track and thus remain poorly characterized. In particular, the specific autoantigens targeted by Tregs remain elusive. Consequently, essential information about human self-specific Tregs' generation, function, and therapeutic potential is missing. This fundamental knowledge gap limits our understanding of human immune tolerance mechanisms and prevents their therapeutic application. We have developed sensitive cytometric technologies for deep molecular and functional characterization of human autoantigen-specific Th cells in various chronic autoimmune diseases (AIDs), identifying a novel Foxp3+ Th cell subset induced by chronic antigen stimulation. Furthermore, screening Treg responses against a wide range of self-antigens in healthy donors revealed Treg responses against known AID target antigens and against novel antigens potentially involved in tissue homeostasis or regeneration. Based on this prior work, RespecTreg will build a unique map of human Treg self-reactivity and deeply characterize prototypic Treg and Th cell responses: RespecTreg will explore fundamental mechanisms of Treg functions and their failure, identify relevant Treg target antigens, analyze Treg antigen receptor (TCR) characteristics, define antigen-related Treg functional diversity, and elucidate mechanisms of their induction and persistence. We will precisely characterize disease-relevant T cell responses in human AIDs or tissue damage. This will guide tailor-made antigen-specific Treg generation for future Treg-based therapies.

Keywords: regulatory t cell,antigen specific t cell,autoimmune disease,human immune response,tissue regeneration
Deploying circular BIOecoNomies at Regional level with a territorial approach (ROBIN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Greece,Spain,Belgium,Slovakia,Germany,Ireland
Call: Regional governance models in the bioeconomy (HORIZON-CL6-2021-GOVERNANCE-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 2499951.0
EU funding (EUR): 2499951.0
Participants: 13
Project status: SIGNED

Europe’s regional authorities have a crucial role to play as agents of just, inclusive and resilient economic development for their territories. ROBIN sets out to empower them to fulfil this role with support to co-shape their governance structures and models in ways that accelerate the deployment of their circular bioeconomy targets, while also promoting social innovation and accounting for different territorial contexts. To this end, we establish and demonstrate the potential of innovative circular bioeconomy governance structures and models in 5 European Regions within Ireland, Germany, Spain, Slovakia and Greece. Our journey begins by setting-up Multi-Actor Regional Constellations engaging key quadruple helix stakeholders to co-create and work alongside novel governance structures, well-embedded within existing organisational structures of our regions and mandated to coordinate and execute circular bioeconomy strategies with and for the entire actor ecosystem and to coordinate effectively with the CCRI-CSO. Along the way, we provide them with tailored support for enhanced and more inclusive stakeholder engagement, as well as a practical toolbox to improve the design, operation and monitoring of their governance models. In parallel, a monitoring and evaluation framework will gauge the performance and impact of our support actions and tools, providing quantifiable evidence of their economic, social and environmental impact. We will use this evidence to engage over 10 additional European regional authorities to test our tools and make a concrete case for their transferability, while also offering mutual learning and capacity building opportunities. In the process we coordinate our actions with the CCRI-CSO and complementary European initiatives to facilitate the dissemination of our results, ensuring their long-term sustainability as viable solutions for supporting EU regions in adopting governance models that facilitate the transition to a Circular Bioeconomy.

Keywords: bioeconomy governance models circular bioeconomy quadruple helix stakeholder engagement inclusion sustainable territorial development
Development and commercialisation of a novel needle tract sealant system for pneumothorax prevention during lung biopsy (Selio System)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 3710858.75
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

Every 30sec someone somewhere globally dies of lung cancer. EU records ~320,000 pa new lung cancer cases. Early lung cancer diagnosis can save lives through timely/efficient interventions. CT guided lung biopsy is the gold standard for lung cancer screening. However, it comes with 62% inherent risk of life-threatening complication pneumothorax (PTX)- a complete or partial lung collapse. PTX sufferers require further radiological scans, needle aspiration, chest tube insertion or surgery- requiring additional hospital stay & ~€15k cost-of-care. Currently no method or device prevents PTX during the percutaneous needle access of lung. Our patented Selio System will be world’s first system specifically designed to prevent PTX occurring before biopsy even takes place. Used by an interventional radiologist before lung biopsy procedure in a 2 min ‘add-on’ to the current standard of care, Selio System pre-seals the needle tract in tissue, thereby preventing air & blood leak from those organs

Keywords: pneumothorax,lung biopsy,biodegradable hydrogel sealant,coaxial delivery needle,lung cancer
Moiré Patterns in Twisted Heterostructures of Ultrathin Metal Halide Perovskite Nanosheets (TWISTPVSK)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-16
End date: 2026-07-15
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

The moiré patterns in the twisted heterostructures of the layered semiconductors such as graphene, transition metal dichalcogenides, h-BN, etc. have led to the emergence of novel exciting properties such as superconductivity, ferroelectricity, enhanced charge transfer at the interface of heterostructures, etc. Despite being a highly desirable phenomenon in the vertical heterostructures of the layered materials, moiré patterns are yet to be explored in the metal halide perovskites. The 2D layered and 3D metal halide perovskites have become one of the most explored classes of semiconductor materials owing to their excellent optoelectronic properties. The TWISTPVSK project aims to generate twisted heterostructures using ultrathin nanosheets of 2D layered perovskites and ultrathin nanosheets of 3D perovskites. The primary goal is to leverage the enhanced optoelectronic properties resulting from moiré patterns for photodetection applications and establish the role of moiré patterns in the generation of new properties in 2D and 3D metal halide perovskites. The key objectives of this proposal are to: i) synthesize twisted heterostructures of ultrathin nanosheets of 2D layered perovskites, study the moiré exciton dynamics using ultrafast spectroscopy, and explore the effect of twisting angle on photodetection efficiency; ii) chemically convert ultrathin 2D layered perovskites into 3D MA-based perovskite nanosheets, create twisted heterostructures of 3D perovskites, investigate moire exciton dynamics, and fabricate photodetectors based on these heterostructures. TWISTPVSK is at the crossroads of chemistry, physics, and engineering; therefore, it will attract significant attention from different disciplines, offer fresh insights into the behavior of metal halide perovskites, and contribute to the development of next generation technologies.

Keywords: twsited heterostructures,moir patterns,ultrathin nanosheets,2d metal halide perovskites,3d ma based metal halide perovskites,photodetectors