Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Pinpoint-NMR: A sequence-specific labeling technique to accelerate NMR investigation of large proteins (PINPOINT-NMR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-06-01
End date: 2028-11-30
Duration (months): 30.0
Total project cost (EUR): 283025.7
EU funding (EUR): 283025.7
Participants: 3
Project status: SIGNED

The cell is an ensemble of dynamic molecular machines. NMR spectroscopy is the method of choice to observe complex conformational changes, transient interactions, and dynamics of proteins at atomic resolution. The introduction of methyl-specific labeling has made it possible to study protein assemblies of several hundred kDa by solution NMR. However, the high number of overlapping signals and the labor-intensive process of site specific analysis hamper NMR investigation of large hetero-oligomeric assemblies at room temperature. While segmental labeling or site-specific labeling offer opportunities to simplify 2D NMR spectra, the complexity of sample preparation or the characteristic low expression yield drastically limit its subsequent applications. Therefore, efficient, widely applicable, and straightforward labeling strategies are necessary to integrate solution NMR analysis of large proteins (such as monoclonal antibodies) into R&D pipelines for biomedical industry. I propose to harness the natural (anti)codon code for multi-site, sequence-specific isotope labeling. The resulting method would simplify the spectral congestion typical of 2D NMR spectra of large proteins, allowing targeted investigation of sites of interest (e.g. catalytic centers) and streamlining residue assignment. This method will reduce the time required for residue specific analysis of NMR data from months to days, thus expanding our ability to study large, medically-relevant complexes and address current biological challenges.

Keywords: protein,nmr,nuclear magnetic resonance,isotopic labeling,methyl,cell free,trna,assignment
Explore Your Brain 2.0: a maximally effective, usable and scalable growth mindset intervention to break through adolescents’ declining rates of motivation and school achievements (EXPLOREYOURBRAIN2.0)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-05-01
End date: 2025-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Adolescence is a period of sharp declines in school motivation and achievement, with negative consequences not only for the academic success and mental wellbeing of youth, but also for teachers and parents. An interesting target for intervention is adolescent’s implicit belief that their abilities are malleable (growth mindset), which has been shown to protect against declines in motivation and achievement, and to boost resilience in school and beyond. This PoC builds on the innovative growth mindset intervention Explore Your Brain (EYB), developed in the ERC StG BRAINBELIEFS. EYB uniquely combines theoretical information about brain plasticity with an experience of influence over one’s own brain, generated using neurofeedback. The results were very promising, but the technology is still in applied research status and not yet easily usable by teachers in the classroom. The main goal of this PoC is to drastically increase the impact that we can achieve on academic motivation, achievement and resilience of high school students by improving our prototype growth mindset intervention. The breakthrough of the innovation depends on increasing usability (Objective 1) and scalability (Objective 2), to maximize the number of adolescents who can profit from the innovation. To reach Objective 1, a Research & Development team including game designers and education specialists will iteratively develop and test Explore Your Brain 2.0 (EYB 2.0) adopting a users-as-designers approach. To reach Objective 2, a Business Development team will develop a business plan for financially and logistically feasible large-scale implementation of EYB 2.0. After completing this project, we hope to implement EYB 2.0 nationally as well as internationally at a large scale, thereby protecting a maximum number of adolescents against declines in school motivation and achievements. This benefits society at large because of higher educational attainment and mental wellbeing of the next generation.

Keywords: mindset,education technology,motivation
Retune the Soundscape of future cities through art and science collaboration (ReSilence)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Countries involved: Greece,Netherlands,Italy,Spain,Germany,France,Hong Kong,Belgium
Call: Art-driven use experiments and design (RIA) (HORIZON-CL4-2021-HUMAN-01, 2021)
Start date: 2022-09-01
End date: 2025-12-31
Duration (months): 40.0
Total project cost (EUR): 2826500.0
EU funding (EUR): 2826500.0
Participants: 12
Project status: SIGNED

A big challenge in the Urbanism/Mobility sector is not anymore to reduce what we call noise but to qualify the soundscape, to shape the vibrations of urban spaces, and to design the ambiance of the city in a way that makes it enjoyable, secure, and familiar. We must consider acting on the sound of the city as a design issue applied to the most immersive “matter” in order to improve the quality of urban life. If Goethe defined music as liquid architecture, he probably meant that this is the dark matter of our urban environment that we should tame, design, and desire. ReSilence will use new technologies (AI & XR) to 1) explore the borders between noise and music in a changing world by producing an acoustic awareness in urban spaces (not only reducing the intensity of noise, but also considering it as an energy producer and designing positive sounds, sounds we want to preserve and multiply), 2) create new types of sonic urban experiences that expand possibilities for accessibility, active participation/engagement, sustainability, and social inclusion, and 3) involve and collaborate with artists in order to leverage multiple sources of inspiration, interdisciplinary collaboration, and build trust around AI & XR technologies. ReSilence will support Art-Driven Experiments (ADE) through Open Calls to artists (type a) and artist-SME teams (type b), with a specific budget allocated for this purpose. Artists in ReSilence will have access to AI and XR technology in order to reflect on novel uses and their impact on society. They will also help in ensuring that the development process and system behavior of the technologies explicitly acknowledge human values and needs.

Keywords: neuro architecture,affective computing,digital art,adaptive 3d models,vr ar,immersive environments,semantic reasoning based on emotion,computer vision and machine learning
HB-086 and HB-097 for Treatment of Chronic Sensory Neuronal Disorders - Neuropathic Pain and Hearing Loss (Sense21)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 3321875.0
EU funding (EUR): 2325312.5
Participants: 1
Project status: SIGNED

HB-086 and HB-097 comprise our portfolio of therapeutic proteins. They are a family of growth factors with actions on sensory nerve cells and represent a novel treatment approaches and a paradigm shift for medical treatment and prevention of severe, chronic conditions as pain and hearing loss. The drug candidates target sensory nerve cells and their support cells in dorsal root ganglia and inner ear. Evidence indicate a mode of action including normalisation of impaired neuronal-glial crosstalk, protection, and regeneration of sensory nerve fibres. All key biological mechanisms underpinning increased peripheral afferent drive associated with chronic pain, and apoptotic hearing loss. Preclinical data confirm that HB-086 completely abolishes pain sensation across different models and HB-097 preserves the sense of hearing in relevant models. Importantly, documented prolonged effects warrant biweekly or monthly dosing and prevention of further disease progression.

Keywords: health related biotechnology,clinical medicine,neuropathic pain,hearing loss,sensory neuronal dysfunction
Digitalised pilot lines for silicon heterojunction tunnel interdigitated back contact solar cells and modules (PILATUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Netherlands,Belgium,Germany,Switzerland,United Kingdom,Czechia,Italy
Call: Demonstration pilot lines for alternative and innovative PV technologies (Novel c-Si tandem, thin film tandem, bifacial, CPV, etc.) (HORIZON-CL5-2021-D3-03, 2021)
Start date: 2022-11-01
End date: 2025-10-31
Duration (months): 36.0
Total project cost (EUR): 13331502.5
EU funding (EUR): 10158731.15
Participants: 21
Project status: SUSPENDED

PILATUS is a 3-year project aiming to demonstrate by 2025 three digitalised pilot lines for the production in Europe of silicon wafers, solar cells, and modules. PILATUS will leverage on the patented and already proven back-contacted silicon heterojunction “tunnel-IBC” technology to ensure achieving its ambitious targets. PILATUS will prove a production capacity of 15 MW for M10 silicon wafers in Norway using polysilicon from Europe and demonstrate the feasibility of an expansion to 5 GW wafer production capacity. PILATUS’ PV module pilot line will reach a minimum of 170 MW of annual production capacity, accompanied with 190 MW cell capacity that by itself adds 30% to the current total capacity for PV cell production in Europe. Combining inline metrology and outdoor monitoring with the support of Industry 4.0 concepts all along the production chain, the cells and modules fabricated on PILATUS’ pilot lines will be analysed and feedback provided to the manufacturing process to ensure reaching ≥ 90 % yield at the end of the project. With the goal to establish PV modules with high durability, PILATUS targets to demonstrate the way towards > 40 years product lifetime by gaining fundamental insights into the degradation mechanisms and providing mitigation solutions thanks to the inline and outdoor metrology units that will be developed in the scope of the project. Further, PILATUS will prove a reduced environmental footprint compared to current technologies by demonstrating modules fully made from recycled materials, eco-design practices to facilitate the dismantling of PV panels, and manufacturing plants compliant with environmental standards. In short, PILATUS will contribute to re-building a “made in Europe”, leading-edge, competitive PV industry with the entire value chain been retained in Europe, compliant to the latest environmental standards, hence fostering the affordability, the security of supply, and the sustainability of the future EU low-carbon energy system.

Keywords: pilot lines,made in europe pv,silicon,heterojunction,back contact,industry 4 0,eco design,recyclability
Scaling of advanced Cultivated Fat for improved Plant based meat alternatives (HF)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Hoxton Farms (HF), founded in 2020 in London by Ed Steele and Max Jamilly, specializes in producing cultivated fat through a scalable biomanufacturing platform. This platform integrates proprietary cell lines, advanced machine learning, mathematical optimization, and patented bioreactors to create high-quality, cost-effective, and delicious animal fat without animals. HF's innovative technology aims to revolutionize the alternative fats and oils market, providing superior, tasty, and affordable fats that offer nutritional, economic, and environmental benefits. HF's vision is to build the world's most scalable and cost-effective platform for mammalian cell biomanufacturing, aiming to become the leading supplier of customizable cultivated fat for plant-based meat companies. Currently, their product line focuses on cultivated pork fat, which has shown success in various kitchen trials. The company has grown to over 40 team members, including 43% female representation and sixteen PhDs from top global universities. Following a successful $3M Seed round in 2020, HF secured a $22M Series A in 2022, enabling the establishment of a cutting-edge research center and testing lab with patented bioreactor prototypes. HF has formed supply partnerships with industry leaders like Nutreco and Reprokine and engaged in R&D projects with major food companies. HF's future focus with the EIC Accelerator will be on commercial and technological de-risking of production, emphasizing process automation, optimization, and quality control. The current technological maturity for small-scale production (TRL 5) has laid the groundwork for cost-effectiveness and productivity economics.

Keywords: cultivated fat,cell biology,machine learning
DETAIL-Interact: Dynamic Engagement and Tailored Interactive Learning for Advanced Robotic Systems (DETAIL-Interact)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-01
End date: 2028-02-29
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 3
Project status: SIGNED

The DETAIL-Interact project, short for Dynamic Engagement and Tailored Interactive Learning for Advanced Robotic Systems, aims to demonstrate how robots master human-like interactive and forceful manipulation skills. Current research on robot manipulation primarily focuses on motion planning for contactless tasks. However, the more challenging domain of contact-rich interactive manipulation tasks has not been thoroughly investigated. Three aspects are crucial: interactive skills representation, robust generalizability, and online adaptation during the interaction. DETAIL-Interact seeks to surpass the state-of-the-art in interactive and forceful manipulation by enabling robots to learn from human demonstrations and exploration strategies. This goal will be achieved using Deep Generative Models (DGMs) for offline imitation learning, which will learn interactive motion priors and the representation of interactive skills. These models will handle high-dimensional demonstration data, including visual inputs, multi-channel force feedback, and robot states among others, essential for mastering forceful interactions. Subsequently, Monte Carlo Tree Search (MCTS) will be innovatively integrated into the receding horizon control framework, utilized for the iterative refinement of online movement through learning and adaptation. This method will optimize movement trajectories and applied forces based on feedback from each interaction and the learned interactive skills. Through this iterative process, the robot will be able to adapt to various interaction environments with differing stiffness levels. The iterative learning process will enhance the robots' performance in precision-oriented tasks, such as selective plant pruning, fruit peeling and cutting, and precise chemical powder grinding. Overall, the DETAIL-Interact project aims to enhance robotic capabilities in interactive and forceful manipulation tasks and is expected to push this topic forward to a higher level.

Keywords: robot interactive manipulation human to robot skill transfer dynamic interactive learning adaptive control deep generative models monte carlo tree search
Structural and mechanistic basis of key intracellular steps of enterovirus infection (EnteroInfection)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-15
End date: 2026-10-14
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

Enteroviruses (EVs) are positive-sense, single stranded RNA virus from the Picornaviridae family. With 106 types, they can cause mild to severe diseases in human, especially children, such as common cold (Rhinovirus), myocarditis (Coxsackievirus B3, CVB3) or poliomyelitis (Poliovirus, PV). EVs are known to remodel the cytoplasm of host cells to create replication organelles allowing efficient viral genome replication. They also hijack the secretory autophagy pathway for replication and viral release. Recent cryo-electron tomography (cryo-ET) work done in the Carlson lab has highlight that PV virions directly assemble on replication membrane through a tethering complex where the tether is thought to be viral ATPase 2C. Moreover, they were able to show one class of autophagosomes is carrying bundles of filament proteins, suspected as filamentous actin (F-actin). My project will address two questions in EV replication: (i) how does the viral protein 2C assist membrane-localized assembly? (ii) what is the identity and role of the filaments in virus-induced autophagy? I will use an integrative approach of cell biology, biochemistry and structural biology and PV and CVB3 will be used as model viruses for this project. I first aim to characterize the viral assembly complex by in vitro reconstitution of the interaction between model membranes, purified 2C, capsid proteins and RNA through cross-linking mass spectrometry (XL-MS) and cryo-ET. By combining focus-ion-beam (FIB) milling and cryo-ET to perform subtomogram averaging, I will study the structure of the tethering complex and the one of the filament proteins found in autophagosomes of infected cells. In parallel, to aid the identification of the filament, I will perform proteomic studies through MS study on isolated autophagosomes infected cells. Finally, combined with knock-out cells, I will be able to identify potential protein candidates and test their effect on EV infection through cryo-ET and live cell imaging.

Keywords: enterovirus,poliovirus,coxsakievirus b3,cryo electron tomography,viral replication,viral release,subtomogram averaging,protein structure,fluorescence microscopy,autophagy
Urban Planning and design ready for 2030 (UP2030)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Climate neutral and smart cities
Destination: Climate neutral and smart cities
Action type: Innovation actions
Countries involved: Germany,Greece,Spain,Netherlands,Italy,Bulgaria,Portugal,Türkiye,Belgium,Croatia,Hungary,Switzerland,United Kingdom,Korea, Republic of
Call: Urban planning and design for just, sustainable, resilient and climate-neutral cities by 2030 (HORIZON-MISS-2021-CIT-02, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 12233133.75
EU funding (EUR): 11081846.0
Participants: 48
Project status: SIGNED

UP2030 aims to guide cities through the socio-technical transitions required to meet their climate neutrality ambitions. It will do so by enabling a quantum leap from a ´business as usual´, project-by-project decarbonisation approach to a vision-driven, strategy-based approach that is anchored on sound projects and renewed policy development. The approach uses urban planning and design as a vehicle to create better connected, more compact, net-zero neighbourhoods in the city pilots – i.e. neighbourhoods that promote liveability and, through designing with intent, promote mitigation action. Unlike fragmented innovation processes that focus on the deployment of a specific solution to achieve incremental progress, UP2030 proposes that cities should themselves be at the centre of the innovation approach to drive transformative change. The project develops the 5UP methodological framework that supports cities in (i) UP-dating those policies, codes, regulations that need to be left behind to make room for the new vision (ii) UP-skilling, through building the capacities of the entire city stakeholder ecosystem that shall deliver actions (iii) UP-grading, through the development of solution prototypes (digital and physical) at selected neighbourhoods, (iv) UP-scaling to achieve city-wide impact by shaping the enabling governance arrangements and matching project portfolios to financial resources, and (v) UP-taking, by engaging with the Mission and sharing best practices across European cities. Inclusive participation is key throughout the project’s full cycle of activities so that real needs of communities are reflected in the city-specific visions, and co-designed interventions maximise delivery of co-benefits. As such, UP2030 will (a) have a measured positive impact on spatial justice in the pilots, and (b) give the opportunity to citizens to participate in the transition by becoming agents of change themselves through their sustainable behavioural shifts.

Keywords: urban design,climate,neutrality,mission,decarbonisation,sustainability,justice,climate resilience,equity