Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Synchronization of Physiological Rhythms between Musicians and Audiences in Live Concerts (SynchInConcert)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway,Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-02
End date: 2026-04-01
Duration (months): 30.0
Total project cost (EUR): 283438.8
EU funding (EUR): 283438.8
Participants: 3
Project status: SIGNED

Heartbeats and breathing rhythms are essential to life. Lab-based research suggests that certain contextual and social factors can impact the interaction between these physiological rhythms, during joint actions such as ensemble playing. SynchInConcert aims at a cutting-edge contribution to the study of physiological rhythms, by investigating, for the first time to our knowledge, the influence between the cardiac and respiratory rhythms of musicians and audiences in live concerts. SynchInConcert will also investigate how these rhythms reflect the aesthetics of the concerts and are influenced by social and contextual components. Three research events will be held with the Stavanger Symphony Orchestra (SSO) and a full audience in a concert hall. During these events, video, audio, cardiac, and respiratory data from selected musicians and audience members will be recorded as well as questionnaires evaluating their level of immersion in the music. A strong interdisciplinary approach will be adopted, by integrating insights, methods and techniques from several disciplines (i.e. music performance science, psychology, physiology, computer science, acoustic engineering and cognitive sciences). Results can significantly contribute to the study of joint actions, by identifying ways in which physiological rhythms support social interactions. The hosts, RITMO Centre of Excellence in Oslo, Casa Paganini in Genoa (secondment) and SSO (placement), offer a unique opportunity to strengthen my expertise in music psychology and performance (focused on sound and behavioral components of interpersonal interactions in small ensembles) to that of music performance physiology in large orchestras. Supported by the outstanding track record of research excellence of the host organizations, the extensive mentorship experiences of my supervisors, and the new set of skills acquired, this fellowship will enhance my prospects for positions of independent researcher within and outside academia.

Keywords: ensemble performance,synchronization,entrainment
Development of Zero-Clinker, Negative-CO2 Concrete from the Atomic Scale (ZeroNegCon)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,Spain,Latvia,France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 5
Project status: SIGNED

The objective of this fellowship is to train Dr Yunjian Li through the research project titled “Development of Zero-Clinker, Negative-CO2 Concrete from the Atomic Scale (ZeroNegCon)”. This project aims to develop zero-clinker, negative-CO2 concrete for sustainable construction and environmental protection by utilising theoretical design at the atomic scale, nanotechnology, electrolysis and carbon mineralisation technology. In this project, the research will uncover the nanoscale mechanisms of C-S-H formation and carbonation, and CaCO3 crystalline phase transformation, providing theoretical guidance for C-S-H preparation and carbonation, and CaCO3 polymorph control. A zero-clinker cementitious material system will be established with in situ synthesis of C-S-H using ions extracted from natural minerals or industrial byproducts through the electrolysis method. Negative CO2 emission in concrete production will be achieved by applying carbon mineralisation technology to the zero-clinker cementitious materials. The project will also focus on the industry application of zero-clinker, negative-CO2 concrete and evaluate its overall performance. This project seeks to revolutionise the field of construction materials by providing a pathway toward significantly reducing carbon emissions in cementitious binders and concrete. By integrating advanced atomistic modelling techniques, nanoengineering and materials science, this research has the potential to set new standards in sustainable construction, influencing future innovations and policy-making in environmental protection and green building technologies. The success of this project will not only advance scientific understanding but also have a far-reaching impact on global efforts to mitigate climate change.

Keywords: zero clinker cement,negative co2 concrete,atomistic simulation,electrolysis for cement production,carbon mineralisation
Fuel cell propulsion system for Aircraft Megawatt Engines (FAME)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Aviation
Action type: Innovation actions
Partnership: CLEAN-AVIATION (JU-JTI)
Countries involved: Germany,France,Spain,Austria,Italy,Poland,Netherlands
Call: Multi-MW Fuel Cell Propulsion System for Hydrogen-Powered Aircraft (HORIZON-JU-Clean-Aviation-2023-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 52372165.2
EU funding (EUR): 34993248.27
Participants: 22
Project status: SIGNED

Green hydrogen as a fuel offers the possibility to significantly reduce aircraft greenhouse gas emissions. When liquid hydrogen (LH2) is used as an energy carrier for power generation with fuel cells (FC), this would result in strongly reduced emissions with no CO2, no SOx and no NOx emissions en route. The development of a hydrogen propulsive FC system as an integral part of a new LH2 aircraft concept would be a possible variant to aim for this. However, this means moving away from the current “plug and play” philosophy (separate motor development and aircraft architecture) towards a disruptive integrated way of development, which requires a co-creation approach of the propulsion system and the aircraft. The focus of FAME is on developing a complete compact high-efficiency multi-MW FC propulsion system based on LH2 as an energy source for short range aircraft. FAME will develop all the subsystems which are needed and integrate these in a MW FC Propulsion System ground demonstrator with the vision to scale it up to aircraft level (sufficient for short range aircraft). This is realised by taking up the above described design path with a collaborative research and development approach between partners involved in development of the needed systems of the fuel cell propulsion system and Airbus as an aircraft designer, manufacturer and integrator. Thus, it is ensured that an optimised design on all levels, starting with material for components and subsystems, up to the propulsion system at the aircraft level, is realised. The system will provide the basis for further activities in Clean Aviation in Phase 2.

Keywords: fuel cell,propulsion system,aviation,megawatt
Fully automated cell-free DNA extraction and quantification - liquid biopsies safely from Patient to Lab (FADEQ)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Challenges
Action type: EIC actions
Countries involved: Finland
Call: Medical Technology and Devices: from Lab to Patient (HORIZON-EIC-2021-TRANSITION-CHALLENGES-01, 2021)
Start date: 2022-04-01
End date: 2025-09-30
Duration (months): 42.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Liquid biopsies are blood tests with growing potential in diagnostics for cancer and prenatal screening. Pre-analytical challenges, such as the need for skilled workforce and strict logistic requirements for samples transportation, are limiting the full exploitation of the method. To address these technical issues, we developed a method for immediate and automated sample processing that provides a sample with higher reliability, less human labour, and less transport requirements. BiopSense innovation is a fully automated disposable cartridge, where the blood is filtrated using a dedicated hollow fiber membrane and then cfDNA is isolated from the plasma in the microfluidic system. The resulting sample can be then transported by regular post and eluted at the destination to carry out the final analysis. The cartridge is controlled by a control unit composed of a vacuum generator, software, and a simple spectrophotometer. In this EIC Transition project our objectives are to validate the automated cfDNA extraction technology and to integrate all the features of the innovation in a single disposable cartridge, which will be ready for marketing, licensing and IVD validation by the end of the project. The cartridge design will be done in close collaboration with the potential customers sector (biotech companies and hospital laboratories) to use their feedback to develop the user interface, manufacturability, and regulatory compliance. The project will focus on the cartridge design and will outsource control unit development to a company with experience in vitro diagnostic devices designing and production. In this project the commercialisation strategy for the next 5-10 years will be developed to define how our start-up company BiopSense will handle the disposable cartridge design and commercialization, and further R&D of the technology in additional applications.

Keywords: liquid biopsy
Business plan optimisation and preparation for scaling of a transcatheter heart valve replacement manufactured using automation (LIFELET)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Ireland
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-06-01
End date: 2024-03-31
Duration (months): 10.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Lifelet Medical is on a mission to deliver one valve for life for patients suffering from heart valve disease. Lifelet is developing a disruptive polymeric heart valve replacement to transcend the limitations of mechanical and animal tissue-based devices available to patients today. Combining the durability of mechanical valves with the blood compatibility and minimally invasive delivery of animal tissue valves, Lifelet’s fully synthetic device aims to enable improved patient outcomes and reduced complications with easier deliverability, enhanced durability, and cost savings for healthcare systems through automated manufacturing and processing. There are 1.2 million patients in the U.S. with severe aortic valve stenosis, and over half of these patients are symptomatic, requiring a heart valve replacement. The transcatheter aortic valve replacement (TAVR) market size is €4B, expected to growth to €7B+ by 2024, with a double-digit CAGR. Thanks to recent clinical trials, indications are being expanded for younger patients, asymptomatic patients, and those at low and intermediate risk for surgery, driving growth of the market. Cardiologists will Lifelet's device with existing reimbursement in place. As a platform technology, the Lifelet polymer may also offer clinical benefits in the treatment of obesity, gastrointestinal diseases, and incontinence. Elle Sander, female CEO and co-founder, is a biomedical engineer who has led the company to a proof-of-principle in chronic sheep studies and is a lead inventor of the material technology, with one patent granted in the EU already. Co-founder and CMO Dr. Faisal Sharif, consultant interventional cardiologist, has a track-record of implanting new devices and a extensive experience of clinical trial development and operations. The team have a passion to commercialise this deep tech, and have the vision to execute on what is required from technical, clinical, regulatory, and commercial perspectives.

Keywords: automation deep tech cardiovascular heart disease sustainability medical device heart valve replacement tavr
It’s (also) what you produce: Experimental Evidence on Creating Markets for Quality in Low-income Countries (MISSINGMARKETS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Sweden,Italy
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2097367.0
EU funding (EUR): 2097367.0
Participants: 2
Project status: SIGNED

Half of the world's extreme poor – or over 430 million people – live in Sub-Saharan Africa. The vast majority live in rural areas and work in agriculture, where productivity is desperately low. This keeps welfare low now – and in the future – as agricultural productivity increases are seen as a condition for both structural transformation and to avoid the worst impacts of climate change. This is the motivation for bringing the green revolution – which has so far bypassed the continent – to Sub-Saharan Africa. Despite the logic being compelling, the results from a decade of research on technology adoption in African agriculture have been largely disappointing. Interventions aimed at increasing farmers ability to invest in inputs to produce more of what they already do have not proven transformative. In this research proposal, I will investigate a complementary explanation why income and productivity in African agriculture remain low: it is what farmers produce – precisely the quality and value added of their output – that keeps them poor, and they produce low quality because there is no demand for smallholders to produce high quality or higher value-added outputs. As low quality limits price and thus farmers' potential income, missing markets for quality can help explain the low returns to farming. At the core of this research proposal is the hypothesis that markets for quality are missing because of a fundamental information problem: quality is a difficult to observe characteristic. I will rely on three multi-wave randomized controlled field trials to study technological and institutional solutions to overcome this information problem, which hamper demand for high quality products in the export market (work package I) and at home (work package II). In the final work package, I will complete the cycle and study how increases in demand for high quality outputs, and access to high quality inputs, can jump-start a green revolution in rural Africa.
Biomolecular regulation with interlocked cyclic oligonucleotides (BioRIcON)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1999799.0
EU funding (EUR): 1999799.0
Participants: 1
Project status: SIGNED

Developing molecules that display protein-like functions and efficiently operate in complex biological environments, e.g. cells, is a grand challenge in chemistry. The aim of BioRIcON is to develop a novel class of biohybrid interlocked molecules (BIMs) that mirrors the function of proteins and enables precise biomolecular regulation. Despite the advances of interlocked molecules, often compared to biological motors, their use in cellular or in vivo settings pales compared to their natural counterparts. BioRIcON comprises an entirely new concept in artificial biology and biomolecular control by yielding BIMs that contain dynamic components ultimately designed to efficiently actuate in cells with high spatio-temporal resolution. I will develop molecular switches and motors using small cyclic oligonucleotides (cONs) that will be mechanically bound – like links in a chain - to other biomolecules to regulate their function. The resulting BIMs merge the best of two worlds: i) the programmability and biocompatibility features of oligonucleotides, and ii) the robustness and scalable production of synthetic mechanically interlocked systems. The goals of BioRIcON include: i) developing BIM-based shuttles and motors that can operate effectively in biological environments, integrate, and react to cellular cues and signaling; ii) exploring mechanical interlocking for reversible molecular display and protection against degradation; iii) implementing BIMs in biomolecular regulation, focused on reversible oligonucleotide-based therapies. BioRIcON will significantly advance the toolbox of biomimetic systems and enable their integration in processes such as gene regulation and protein expression. BIMs use mechanical interlocking to reversibly protect and control biomolecular function in an adaptative manner, with a focus on RNA regulation which will help unravel the mechanisms of fundamental biological processes and hold enormous innovative potential in biosensing and biomedicine.
COgnitive Dynamics in Early Childhood (CODEC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Cognitive ability, measured through standardized tests, provides a highly predictive measure of lifespan outcomes including academic achievement, job success, as well as mental and physical health. However, these cognitive snapshots omit a crucial aspect of cognitive ability: Short term variability in cognitive performance. Individuals with more variable performance are more likely to be mis-stratified into schools or careers with potential lifelong consequences, and more likely to perform at levels that necessitate intervention for periods of time. Moreover, variability reflects a promising early warning marker of adverse outcomes, above and beyond mean performance. However, the challenges involved in measuring variability have left crucial questions unanswered: Is variability a single trait, or does it have distinct factors? What are the neural and behavioural determinants of cognitive variability? What is the association between short term variability and long-term outcomes? In this unique longitudinal design using gamified versions of classic cognitive domains I will measure variability across a range of tasks at multiple levels of temporal resolution: months, days, occasions and trials. 600 children (200 in the neuroimaging arm) will be measured for period of three years. Once per year they will take part in a burst: A week where they will be measured three times a day. I will use using cutting edge methodology to understand the behavioural, neural and environmental mechanisms of variability, as well as the longitudinal consequences of variability on cognitive development and the emergence of mental health symptomatology such as ADHD. By combining the strengths of deep phenotyping with cutting edge quantitative modeling, I will be able to test and develop theories of cognitive development, demonstrate the role of brain structure and function in supporting cognitive dynamics and determine the effect of cognitive variability on developmental outcomes.
MEthodology of Psycho-pedagogical, Big Data and Commercial Video GAmes procedures for the European SKILLS Agenda Implementation (MEGASKILLS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Spain,Belgium,Czechia,United Kingdom
Call: Conditions for the successful development of skills matched to needs (HORIZON-CL2-2022-TRANSFORMATIONS-01, 2022)
Start date: 2023-02-01
End date: 2026-01-31
Duration (months): 36.0
Total project cost (EUR): 2435145.0
EU funding (EUR): 2435145.0
Participants: 9
Project status: SIGNED

According to the importance of soft skills in the European Skills Agenda (transversal skills in the document) the EU has tackled this gap by working with competency and skills definition models such as EntreComp, LifeComp and ESCO classification. However, there are still at least two important gaps between soft skills and both the education and the labour market: High atomization and the absence of rigorous and affordable training and assessment methods. MEGASKILLS is a project whose main objective is to help bridge these gaps between education and the labor market through the research and design of an innovative and affordable methodology for training and evaluating soft skills through 3 main research tasks to figure out how to: 1) reach a consensus pact for soft skills taxonomy and normalization based on the manifest needs of industry and education; 2) training and evaluation techniques through the use of the massive amount of data from the interactions of players with their favorite video games (considering the very high penetration of video games among working-age citizens in Europe) and the use of AI and machine learning algorithms and 3) implement methodologies and educational designs that will build an affordable strategy for the new educational-labour paradigm at a European level. Thanks to this approach MEGASKILLS will intend to respond to at least six different Actions within the European Skills Agenda. The only way to address the gap between education, key productive sectors and their skills in demand and at the same time to comply with several of the points of the European Skills Agenda is from a perspective that is all rigorously scientific, multidisciplinary and disruptive as MEGASKILLS is. For the MEGASKILLS consortium, this disruptive approach must come from techniques and methodologies that can be both affordable and massive enough so that the impact on the labour and educational sectors is remarkable and sustainable both socially and economicall

Keywords: soft skills transversal skills videogames industry employment