Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Developing and Evaluating Communication strategies to support Informed Decisions and practice based on Evidence. (DECIDE)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: United Kingdom,Norway,Spain,Netherlands,Switzerland,Germany,United Kingdom,United Kingdom,United Kingdom,Italy,Finland
Call:  (FP7-HEALTH-2010-two-stage, 2010)
Start date: 2011-01-01
End date: 2015-12-31
Duration (months): 60.0
Total project cost (EUR): 3788498.63
EU funding (EUR): 2999312.1
Participants: 13
Project status: CLOSED

Objective: To improve the dissemination of evidence-based recommendations by building on the work of the GRADE Working Group to develop and evaluate methods that address the targeted dissemination of guidelines. Background: Healthcare decision makers face challenges in understanding guidelines, including the quality of the evidence upon which recommendations are made, which often is not clear. Guidelines are also typically developed as a one-size-fits-all package. By developing and evaluating targeted dissemination strategies, DECIDE aims to increase the use of evidence-based interventions in a sustainable way and to reduce the use of interventions where benefits are uncertain. Methods: GRADE is a systematic approach towards assessing and communicating the quality of evidence and the strength of recommendations. It has been developed to address the weaknesses of other grading systems and is now widely used internationally. The DECIDE consortium, which is composed of members of the GRADE Working Group, will further develop this approach to ensure effective dissemination of evidence-based recommendations targeted at the key stakeholders (healthcare professionals; policymakers and managers; patients and the general public) who determine what happens in clinical practice. We will collect stakeholder input from advisory groups, consultations and user testing. This will be done across a wide range of health systems in Europe. The targeted dissemination strategies that are developed will be evaluated in randomized trials, refined and used and evaluated with real guidelines developed by the DECIDE partners and other guideline developers that we support. Expected results: Dissemination strategies for recommendations that have been rigorously evaluated in diverse settings, support the transfer of research into practice, and are adapted to real-world healthcare systems.

Keywords: dissemination,research into practice,quality of evidence,strength of recommendations,clinicians,patients,policymakers,guidelines
Cognitive Heterogeneous Reconfigurable Optical Network (CHRON)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Pervasive and Trustworthy network and service infrastructures
Action type: Collaborative project
Countries involved: Spain,Denmark,Germany,Poland,Greece,Italy
Call:  (FP7-ICT-2009-5, 2009)
Start date: 2010-07-01
End date: 2013-09-30
Duration (months): 39.0
Total project cost (EUR): 3150342.0
EU funding (EUR): 2329080.0
Participants: 8
Project status: CLOSED

The CHRON project addresses the challenge of controlling and managing the next generation of heterogeneous optical networks supporting the Future Internet. Such networks will be of a highly heterogeneous nature, ranging from a wide variety of classes of services with different requirements, to wide physical layer diversity in optical transmission techniques and optical switching paradigms. The CHRON project proposes a Cognitive Heterogeneous Reconfigurable Optical Network, which observes, acts, learns and optimizes its performance. The focus of the project is on the essential elements of the proposed cognitive network, in particular a cognitive decision system; an intelligent monitoring system; and a cognitive control system. The project proposes a cognitive and dynamic approach to tackle the lack of dynamicity of current optical network control planes; especially in view of the emerging levels of dynamic switching paradigms that can co-exist in a single future network. CHRON will investigate intelligent monitoring techniques to account for advanced optical transmission techniques based on complex modulation formats with coherent detection that are being considering for achieving bit rates up 100 Gbit/s and beyond. The CHRON project will consider the interconnectivity between service classes, traffic types and the proposed cognitive system for reducing control and management complexity, augmented flexibility and efficient use of network resources. The proposed cognitive network can also perform cross-layer design and multi-objective optimization supporting trade-offs between performance in term of cost and energy efficiency. The CHRON project will perform simulation and experimental studies to test and validate the developed cognitive control and monitoring techniques in a heterogeneous optical network emulation. The project also includes activities and strategies for intensive dissemination, standardisation and exploitation of achieved results.

Keywords: future internet,optical networking,cognitive network,network monitoring,gmpls,quality of service,quality of transmission,dynamic circuit switching
Rock Hyrax Middens and Climate Change in Southern Africa during the last 50,000 years (HYRAX)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Earth system science
Countries involved: France,United Kingdom
Call:  (ERC-2010-StG_20091028, 2010)
Start date: 2010-11-01
End date: 2016-10-31
Duration (months): 72.0
Total project cost (EUR): 1484046.0
EU funding (EUR): 1484046.0
Participants: 2
Project status: CLOSED

In stark contrast to the abundance of high quality palaeoenvironmental records obtained from the temperate regions of the northern hemisphere, terrestrial palaeoenvironmental information from southern Africa's drylands comes from discontinuous deposits with poor absolute age control and ambiguous palaeoclimatic significance. Confronted with the possibility of future environmental and social disruption as a result of climate change, the need for reliable records from southern Africa has never been so acute. This project seeks to develop rock hyrax middens as novel palaeoenvironmental archives to investigate long-term climate change. Hyrax middens (fossilised accumulations of urine and faecal pellets) contain a range of palaeoenvironmental proxies, including fossil pollen and stable isotopes. As part of a pilot study, I have created new collection and sampling methodologies, establishing the proof of principle and showing that middens provide continuous sub-annual to multi-decadal multi-proxy records of environmental change spanning the last 50,000 years. This work has been exceptional in terms of its ability to elucidate long-term climate dynamics at the local scale, and I now intend to apply my techniques to studying environmental change across the whole of southern Africa, a climatically sensitive, but poorly understood region of the globe. Developing new sites, proxies and analytical techniques, HYRAX will provide the first opportunity to study rapid climate change events, the extent and phasing of major climatic phenomena, and the direction and potential impacts of future climate change.

Keywords: biodiversity,origins of modern human behaviour
Analysis of optimal sets and optimal constants: old questions and new results (ANOPTSETCON)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Mathematical foundations
Countries involved: Germany,Italy,Italy
Call:  (ERC-2010-StG_20091028, 2010)
Start date: 2010-08-01
End date: 2015-07-31
Duration (months): 60.0
Total project cost (EUR): 540000.0
EU funding (EUR): 540000.0
Participants: 3
Project status: CLOSED

The analysis of geometric and functional inequalities naturally leads to consider the extremal cases, thus looking for optimal sets, or optimal functions, or optimal constants. The most classical examples are the (different versions of the) isoperimetric inequality and the Sobolev-like inequalities. Much is known about equality cases and best constants, but there are still many questions which seem quite natural but yet have no answer. For instance, it is not known, even in the 2-dimensional space, the answer of a question by Brezis: which set, among those with a given volume, has the biggest Sobolev-Poincaré constant for p=1? This is a very natural problem, and it appears reasonable that the optimal set should be the ball, but this has never been proved. The interest in problems like this relies not only in the extreme simplicity of the questions and in their classical flavour, but also in the new ideas and techniques which are needed to provide the answers. The main techniques that we aim to use are fine arguments of symmetrization, geometric constructions and tools from mass transportation (which is well known to be deeply connected with functional inequalities). These are the basic tools that we already used to reach, in last years, many results in a specific direction, namely the search of sharp quantitative inequalities. Our first result, together with Fusco and Maggi, showed what follows. Everybody knows that the set which minimizes the perimeter with given volume is the ball. But is it true that a set which almost minimizes the perimeter must be close to a ball? The question had been posed in the 1920's and many partial result appeared in the years. In our paper (Ann. of Math., 2007) we proved the sharp result. Many other results of this kind were obtained in last two years.

Keywords: optimal constants,optimal sets,geometric inequalities,sobolev-poincare constant
Collaborative, Complex and Critical Decision-Support in Evolving Crises (TRIDEC)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Digital libraries and content
Action type: Collaborative project
Countries involved: Germany,United Kingdom,United Kingdom,Austria,Germany,Portugal,Italy,Türkiye,Austria
Call:  (FP7-ICT-2009-5, 2009)
Start date: 2010-09-01
End date: 2013-10-31
Duration (months): 38.0
Total project cost (EUR): 8898342.0
EU funding (EUR): 6794766.0
Participants: 11
Project status: CLOSED

TRIDEC focuses on new technologies for real-time intelligent information management in collaborative, complex critical decision processes in earth management. Key challenge is the construction of a communication infrastructure of interoperable services through which intelligent management of dynamically increasing volumes and dimensionality of information and data is efficiently supported; where groups of decision makers collaborate and respond quickly in a decision-support environment. The research and development objectives include the design and implementation of a robust and scalable service infrastructure supporting the integration and utilisation of existing resources with accelerated generation of large volume of data. These include sensor systems, geo-information repositories, simulation- and data-fusion-tools. A knowledge-based service framework is deployed for context information and intelligent information management with flexible orchestration of system resources. An adaptive framework for collaborative decision making is enabled with new functions for the support of complex business processes. TRIDEC will be demonstrated within two scenarios. Both involve intelligent management of large volumes of data for critical decision-support. One concerns a large group of experts working collaboratively in crisis centres and government agencies using sensor networks. Their goal is to make critical decisions and save lives, infrastructural and industrial facilities in evolving tsunami crises. The other concerns a large group of consulting engineers and financial analysts from energy companies working collaboratively in sub-surface drilling operations. Their common objective is to monitor drilling operations in real-time using sensor networks, optimising drilling processes and critically detecting unusual trends of drilling systems functions. This prevents operational delays, financial losses, and environmental accidents and assures staff safety in drilling rigs.

Keywords: decision support,crises management,natural hazards,drilling,intelligent geo-information management,earth management
Fast Automated Multiplex Analysis of Neonatal Sepsis Markers on a Centrifugal Microfluidic Platform (ASCMICROPLAT)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: Germany,Ireland,Switzerland,Finland,Germany
Call:  (FP7-HEALTH-2010-two-stage, 2010)
Start date: 2011-01-01
End date: 2014-06-30
Duration (months): 42.0
Total project cost (EUR): 2574757.2
EU funding (EUR): 1961627.0
Participants: 5
Project status: CLOSED

The global frequency of neonatal sepsis is 1-21 newborns per 1000 live births with mortality rates as high as 35-70%, amounting to 100,000s of annual cases. The consortium has identified a real and pressing need for increasing diagnostic efficacy in a setting that imposes a dramatic healthcare burden on EU (and global) healthcare management systems. The goal of this project is the realization and clinical validation of a fully integrated and automated platform for the parallel detection of neonatal sepsis markers and a panel of sepsis-causing bacteria from a clinical sample (whole blood, cerebrospinal fluid, fluid from joint aspirations or urine). For the first time, this will allow a fast (90 minutes) automated routine diagnosis of neonatal sepsis, permitting a timely and especially specific treatment. The project has the potential to significantly reduce neonatal mortality and ensure appropriate treatment for one of the most vulnerable patient cohorts in the medical setting: newborns. The interaction between presence of microbial pathogens and the host (patient) response will be investigated in a clinical validation phase with a view to planning patient management more appropriately. In the long term this will also reduce the spread of multiresistant strains emerging from the unspecific use of broad-spectrum antibiotics. ASCMicroPlat will cover the complete value chain from research and development to clinical validation. The system will be based on the centrifugal microfluidic platform of HSG-IMIT and an inventive foil-technology for the disposable test carriers, which is scalable to industrial production. ASCMicroPlat will enable a sepsis diagnosis based on a “sample in – result out” process. Additionally, the know-how generated in this project will provide innovative European SMEs with a platform for the fast implementation of lab-on-a-chip tests. The consortium has a strong industrial component including 2 SMEs.

Keywords: neonatal sepsis,biomarker,centrifugal microfluidics,lab-on-a-chip
Enzyme Driven Molecular Nanosystems (EMERGE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Materials and Synthesis
Countries involved: United Kingdom
Call:  (ERC-2010-StG_20091028, 2010)
Start date: 2011-01-01
End date: 2015-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Functional nanomaterials are predicted to have an enormous impact on some of the most pressing issues of 21st century society, including next-generation health care and energy related technologies. Bottom-up approaches, using self-assembly principles, are increasingly considered to be the most appropriate routes for their synthesis. Indeed, Science magazine highlighted How far can we push chemical self-assembly? as one of the 25 biggest questions that face scientific inquiry over the next quarter century. Despite significant advances in recent years, it is still a major challenge to access precisely defined nano-structures in the laboratory, especially if these do not represent the global free energy minimum (i.e. are asymmetric, multifunctional, compartmentalized and/or dynamic). The biological world provides numerous outstanding examples of highly complex functional nano-scale architectures with attractive features such as defect repair, adaptability, molecular recognition and programmability. It is the objective of this ERC Starting Grant to develop and exploit the concept of (bio-)catalytic self-assembly, a bio-inspired approach for bottom-up synthesis of complex nanomaterials. We will explore three unique features of these systems (i) spatiotemporal control, (ii) catalytic amplification, either towards or away from equilibrium and the tempting vision of (iii) dynamic systems with emergent properties. In our approach we aim to encompass the entire spectrum from fundamental understanding to eventual societal benefit. Alongside the fundamental aims, we wish to put our methodologies to use, in collaboration with experts in these fields, to develop novel functional materials towards applications in next-generation biomaterials and gel-phase supramolecular (opto-) electronic materials.

Keywords: systems chemistry,self-assembly,biocatalysis,soft matter,chemical nanosystems
Statistics for Complex Data: Understanding Randomness, Geometry and Complexity with a view Towards Biophysics (COMPLEXDATA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Mathematical foundations
Countries involved: Switzerland
Call:  (ERC-2010-StG_20091028, 2010)
Start date: 2011-06-01
End date: 2016-05-31
Duration (months): 60.0
Total project cost (EUR): 681145.6
EU funding (EUR): 681145.6
Participants: 1
Project status: CLOSED

The ComplexData project aims at advancing our understanding of the statistical treatment of varied types of complex data by generating new theory and methods, and to obtain progress in concrete current biophysical problems through the implementation of the new tools developed. Complex Data constitute data where the basic object of observation cannot be described in the standard Euclidean context of statistics, but rather needs to be thought of as an element of an abstract mathematical space with special properties. Scientific progress has, in recent years, begun to generate an increasing number of new and complex types of data that require statistical understanding and analysis. Four such types of data that are arising in the context of current scientific research and that the project will be focusing on are: random integral transforms, random unlabelled shapes, random flows of functions, and random tensor fields. In these unconventional contexts for statistics, the strategy of the project will be to carefully exploit the special aspects involved due to geometry, dimension and randomness in order to be able to either adapt and synthesize existing statistical methods, or to generate new statistical ideas altogether. However, the project will not restrict itself to merely studying the theoretical aspects of complex data, but will be truly interdisciplinary. The connecting thread among all the above data types is that their study is motivated by, and will be applied to concrete practical problems arising in the study of biological structure, dynamics, and function: biophysics. For this reason, the programme will be in interaction with local and international contacts from this field. In particular, the theoretical/methodological output of the four programme research foci will be applied to gain insights in the following corresponding four application areas: electron microscopy, protein homology, DNA molecular dynamics, brain imaging.

Keywords: functional data analysis,inference for random processes,statistical inverse problems,shape theory,regularization,electron microscopy,protein homology,dna molecular dynamics,biomedical imaging
Mid-InfraRed Active photonic integrated Circuits for Life sciences and Environment (MIRACLE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Systems and communication engineering
Countries involved: Belgium,Netherlands
Call:  (ERC-2010-StG_20091028, 2010)
Start date: 2010-12-01
End date: 2015-11-30
Duration (months): 60.0
Total project cost (EUR): 1451400.0
EU funding (EUR): 1451400.0
Participants: 2
Project status: CLOSED

My group will explore the new field of photonic integrated circuits for the mid infrared (MIR) wavelength band based on high-index contrast waveguide structures. This research is fueled by the need for compact, integrated solutions for spectroscopic sensor systems in the MIR for biomedical applications and environmental monitoring, since most molecules have fingerprint absorption lines in this wavelength range. The project is based on the use of high index contrast group IV waveguide systems. To extend the functionality of the photonic integrated circuit, my group will heterogeneously integrate other materials (III-V semiconductors, LiNbO3, MCT, chalcogenides, polymers) on the high index contrast waveguide system for particular optical functions. My group will start exploring this field by focusing on three cornerstone applications. The research will focus on the realization of a MIR lab-on-a-chip spectroscopic system, a fully integrated MIR Fourier Transform InfraRed spectroscopy system (FTIR) and an integrated optical parametric oscillator to address new wavelength ranges, all integrated on a silicon photonic integrated circuit. Each of these three cornerstones would be world s first mid-infrared systems-on-a-chip and thus a breakthrough. Inherently this makes this a relatively high risk/very high gain proposal. My group will combine the strengths of the two institutes which support this proposal, i.e. the world class silicon photonics and heterogeneous integration technology at Ghent University/IMEC and the world class III-V and plasmonic technology at the Technical University of Eindhoven. I strongly believe that my program will open a whole new window of opportunities in the mid-infrared with a large impact on science and society.

Keywords: mid-infrared photonic integrated circuits