Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nontrivial Vortex States and their Connection to the Transition to Turbulence (TTT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-10-01
End date: 2010-09-30
Duration (months): 24.0
Total project cost (EUR): 162985.98
EU funding (EUR): 162985.98
Participants: 1
Project status: CLOSED

The applicant will study the existence of unstable nonlinear travelling wave solutions to the Navier-Stokes equations in isothermal ducts of square and rectangular cross-section where the basic flow is homogeneos in the streamwise direction. After this, more challenging situations will be considered with streamwise inhomogeneous base flows: boundary layer and backward facing step . Discovering such states is crucial for the understanding of turbulence and for its control. Relating the solutions found to experimental/DNS observations of vortices in square ducts is a clear step towards the development of ”Hopf theory of chaos”, which interprets turbulence as the wandering of the flow system’s trajectory in phase space among mutually repelling states. Further progress towards a dynamical-system-based theory of turbulence will be achieved by assessing the 3D global stability of the states found. The fellow will acquire complementary skills in parallel computing and collaborate to the development of novel numerical algorithms for global stability problems. The minimum direct outcome of the research will be three papers in leading archival journals; more importantly, the research will open a new path in the study of turbulence. The proposed project fits with ongoing research at Genova and matches perfectly the fellow’s ambitions and interests. The researcher will find the ideal environment to expand his scientific expertise in fluid mechanics, stability theory and parallel computing.

Keywords: transition to turbulence,hydrodynamic stability,engineering mathematics
Compact Binaries as Gravitational-Wave Sources (COMPACT BINARIES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2008-09-15
End date: 2010-09-14
Duration (months): 24.0
Total project cost (EUR): 161398.35
EU funding (EUR): 161398.35
Participants: 1
Project status: CLOSED

We propose a research program to explore the implications of compact binaries, with emphasis on pulsar binaries, for gravitational-wave astronomy. Interest in compact binaries derives not only from an intrinsic motivation of understanding their origin and evolution in various astrophysical environments, but also from the fact that these are strong sources of gravitational waves. Pulsar binaries, one of the prime targets for ground-based gravitational-wave detectors, form a subgroup of compact binaries. This work will involve (a) a comprehensive study on the empirical properties of Galactic pulsar population and (b) a systematic analysis to constrain theoretical models on binary evolution using the empirical rate estimates relevant to pulsar binaries. Establishing the preferred model parameter space will allow us to explore various types of compact binaries with better constraints. This work can be expanded to study statistics of gamma-ray bursts, which are also strong sources of gravitational waves. As one of the short-term projects, we will compare observational properties of gamma-ray bursts with theoretical predictions. This study will provide a unique tool to quantify uncertainties in theoretical assumptions on the formation and evolutionary channels of compact binaries, as well as to calculate more reliable rate estimates for the gravitational wave detection for the current and future detectors.

Keywords: astrophysics,pulsar binaries,gravitational-wave detection,gamma-ray bursts,binary evolution,globular clusters,statistical analysis
Metal and Organo-Catalysts for the Production of 1,2-Diamines (MOC-DA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-10-01
End date: 2010-07-31
Duration (months): 22.0
Total project cost (EUR): 169390.93
EU funding (EUR): 169390.93
Participants: 1
Project status: CLOSED

The well-known occurrence of vicinal diamines in biologically active molecules and natural products has led to the need for efficient and reliable methods for the stereoselective introduction of this functional group. Methodologies for the preparation of vicinal diamines from olefins are scarce and certainly none that can provide enantiopure diamines exists. This proposal outlines two new methods for the catalytic oxidation of alkenes to produce enantiopure 1,2-diamines in one step. The objectives of the program of research are: 1. Examination of transition metal catalysed bis-amination of alkenes. 2. Investigation of amine-catalysed addition of diimides to alkenes. 3. Extension of these new methods to the synthesis of complex natural products with biological activity. The asymmetric induction of these reactions will be thoroughly studied by means of chiral additives. In target 1, the addition of a chiral ligand will be explored, while in target 2, the addition of a chiral amine will be used to induce diastereoselectivity. The aim of this project is to contribute to Organic Chemistry with new catalytic, asymmetric routes to achieve diamine-based products with interesting biological activity. There is ample opportunity for study of a broad range of reactions and plenty of back-up plans exist. This project will, therefore, comprise of an ideal mix of mechanistic study and exposure to synthesis which will provide an ideal training for a postdoctoral researcher. Furthermore, the well-known difficulties arising from catalytic reactions and asymmetric synthesis in general will have to be overcome, making the proposal challenging. This project will increase the knowledge of the scientific community in the use of asymmetric catalytic reactions in organic synthesis and drug discovery. Actually, the development of new catalytic reactions is one of the most pressing goals for chemical industry which has an ever-increasing need for new, clean and powerful reactions.

Keywords: organic chemistry,catalysis,diamination,alkenes,osmium,asymmetric synthesis,diamines,natural products
The Effects of Precarious Work on Family Life in Europe (EPFLE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2009-12-17
End date: 2011-07-16
Duration (months): 19.0
Total project cost (EUR): 153687.01
EU funding (EUR): 153687.01
Participants: 1
Project status: CLOSED

This project investigates the effects of precarious work on family life in Europe. So far research on precarious work has mainly focused on effects on the labour market itself. However, with an increasing fragmentation of work histories, we have to expand our focus beyond the labour market and analyse the effects of non-traditional work forms on the lives of individuals and their families. Traditional assumptions about the separation of work life and private life are no longer feasible since working time and non-working time become increasingly interconnected in both a short-term and a long-term perspective. Being exposed to high labour market risks over the life course is likely to lead to changes in social behaviour and consequently to new social outcomes, which in turn require adjusted labour market policies. Exposure to risk may be especially consequential in critical life course periods which coincide with the need to make long-term commitments (such as in partnership and parenthood). This research project pins down the social effects of precarious work along two crucial dimensions of family life: (1) fertility and family formation and (2) family organisation and within-family time-use. It focuses on Germany, Italy, Poland, Sweden and the UK, representing five different welfare state regimes. From a methodological perspective, this research programme integrates economic and sociological research, also combining quantitative (i.e. microeconometric) and qualitative (i.e. case study) research. While micro-datasets and various national time-use data allow an analysis of fertility and within-family time-use, additional qualitative case studies in the above mentioned countries provide an in-depth analysis of the impact of precarious work on the life of families.

Keywords: social sciences,sociology of labour,labour market studies
Time-frequency analysis of paraproducts (PARAPRODUCTS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-10-15
End date: 2010-10-14
Duration (months): 24.0
Total project cost (EUR): 161792.99
EU funding (EUR): 161792.99
Participants: 1
Project status: CLOSED

Singular integral operators form one of the most important classes of operators in Mathematical Analysis and its applications. Paraproducts are special operators from this class, which are at the same time the "building blocks" for general singular integral operators. These special singular integral operators are particularly useful in the study of certain partial differential equations . Similarly to multiplier operators like the classical Hilbert transform, they are characterized by the fact that their frequency singularity is localized in a single point. In the last ten years, there has been huge interest for a new kind of singular integrals: so-called modulation invariant Calderón-Zygmund operators, which main feature is that their frequency singularities are spread over large varieties. This is for example the case for the bilinear Hilbert transform, whose singularities localize in a line in the plane. Our project proposes the study of tensor products of singular integrals that mix both types of singularities, since these are defined by a symbol given by the product of a classical paraproduct symbol and a modulation invariant one. The main tool for such a task will be the time-frequency analysis, which has already been applied to great success in the modulation invariant setting. This project can be considered as the next basic step in the future evolution of modern singular integral theory.

Keywords: mathematical analysis,fourier analysis,time-frequency analysis,singular integral operators,paraproducts,wave packets
Organic Optoelectronic Device (PORASOLAR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2009-01-01
End date: 2010-12-31
Duration (months): 24.0
Total project cost (EUR): 169094.27
EU funding (EUR): 169094.27
Participants: 1
Project status: CLOSED

This program targets the development of novel porphyrin-based organic light-harvesting materials exhibiting satisfactory solubility, physical and electrochemical properties and light conversion efficiency. Fabrication of stable organic solar device with up to 5 % power conversion efficiency will be pursued. It builds directly upon the world leadership in organic polymer based solar cells of Linz institute for organic solar cells (LIOS) and the applicant’s professional expertise in synthesis of porphyrin and highly conjugated compounds for light-harvesting application. A synthetic strategy addressed in the project is the combination of porphyrin and appropriate co-absorber in a form of triazine derivatives to achieve extensive light-harvesting ability throughout visible spectrum. Effects of porphyrin-co-absorber linkers, attachment sites, central metal on the porphyrin ring and solubilizing groups on the photoactivity of the compounds will be investigated to optimize the molecular structure and functionality. In order to reach the proposed goal, the project will bring together the established expertise of the project participants in the development of organic light harvesters, photophysical and photochemical characterization of such materials and reel to reel device fabrication and optimization. The achievement of the project objectives will establish the potentiality of this technology to achieve a step change to higher organic photovoltaic device efficiency and economically reasonable and environmentally friendly production process.

Keywords: natural sciences,organic solar cell,solar cell,photovoltaic cell,light-harvesting device,porphyrin,triazine
Topological and functional modularity in biological regulatory networks (MODULAR NETWORKS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2008-07-01
End date: 2010-06-30
Duration (months): 24.0
Total project cost (EUR): 171132.78
EU funding (EUR): 171132.78
Participants: 1
Project status: CLOSED

Most functions and structures in living organisms seem to depend on subsets of elements organized as modules. In a modular system a certain process, performed by a module, does not depend heavily on the elements outside the module, and hence it is semi-autonomous. Modularity promotes evolvability, an organism’s capacity to generate heritable phenotypic variation, because it permits adjustment of a module without perturbing other functions and allows the combination of previously evolved functions. Understanding modularity is critical for the study of evolution and development of phenotypic traits. As several biological regulatory systems can be represented as directed networks, it would be useful to study these representations of biological systems to search for network traits that could underlie modules, and to test under which evolutionary scenarios these traits may appear. Modularity in networks has been addressed by looking for densely connected groups of nodes with sparser connections between groups. This is appropriate for undirected networks, but with directed networks a dense connectivity in a group of nodes does not suffice for semi-autonomous behavior. Feedback loops and strongly connected components (SCC) might be related to the behavior expected for a module, and thus, be considered structural signatures of modules. If this is the case, we would find more of these structures in regulatory (modular) networks than expected by chance. The first objective of this project is to test if the perceived abundance of loops and SCCs in regulatory networks is statistically significant. No study has addressed the appearance of loops and SCCs in directed networks and its relationship to modularity under realistic evolutionary scenarios. In this project several evolutionary scenarios for the evolution of modularity in directed networks will be tested, avoiding most limitations in previous attempts.

Keywords: module,network,computational biology,evolutionary biology,developmental biology
Characterization of signalling functions and genomic targets of SWI3C-associated chromatin remodelling complexes (SWI3C-CRCS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-05-01
End date: 2010-04-30
Duration (months): 24.0
Total project cost (EUR): 166982.27
EU funding (EUR): 166982.27
Participants: 1
Project status: CLOSED

Chromatin-remodelling complexes (CRCs) play pivotal roles in the regulation of basic cellular processes, including transcription, DNA replication, repair and cell cycle in eukaryotes. Although several orthologues of CRC components are conserved between higher plants and other eukaryotes, our current knowledge on plant CRCs is rather limited. To unravel the regulatory functions of SWI/SNF-type CRCs, the proposed study focuses on functional analysis of SWI3 core subunits that are linked by ATPases and other interacting factors to specific signalling pathways. Recently, we demonstrated that SWI/SNF CRCs in Arabidopsis carry different combinations of SWI3 subunits that play distinct and essential roles in the control of cell differentiation, organ development, flowering time and gene silencing. The SWI3 subunits show unique interactions with several signalling factors, such as the flowering time regulator FCA. Through their SNF5/BSH CRC subunit, the CRC complexes interact with conserved components of stress signalling pathways, including the AMPK-activated protein kinases. The proposed training project is based on a focused multidisciplinary approach, which aims at the characterization of regulatory roles of SWI/SNF CRC complexes that carry ATSWI3C subunit. Complementary tasks of the experimental work plan include: i) the isolation and mass spectrometry analysis of CRC complexes carrying affinity tag labeled SWI3C subunit, ii) identification of genomic targets of SWI3C containing CRCs by chromatin cross-linking, iii) analysis of function of SWI3C-associated CRC components using reverse genetics, and iv) study of in vivo nuclear interaction of CRC subunits using fluorescence energy transfer-based confocal microscopy. The project is aided by expert mentoring activity of the host and is embedded in a carrier development plan envisioning long-term collaborative interaction with the researcher upon his return to the home institute.

Keywords: chromatin remodelling,regulation of gene expression,stress signalling,chromatin cross-linking,maldi,fret
Understanding the mechanism behind ADAR1 (Adenosine DeAminase acting on RNA 1) modulation of the RNA interference pathway. (ADAR1 AND RNAI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2008-06-01
End date: 2010-05-31
Duration (months): 24.0
Total project cost (EUR): 169957.94
EU funding (EUR): 169957.94
Participants: 1
Project status: CLOSED

The most common form of editing in mammalian RNA is deamination of adenosine to inosine by ADAR1 and ADAR2. ADAR1p150, an interferon inducible adenosine deaminase, is also known to antagonize RNA interference (RNAi). To date, the mechanism by which this is carried out is unclear. For example, it is unknown if the embryonic lethality of ADAR1 knockout mice is related to antagonism of RNAi. Thus, I propose to study how ADAR1 antagonizes the RNAi pathway and if it interacts directly with RNAi components. Mutants of ADAR1 have been generated in the host laboratory. I propose to examine the activity of each mutant against RNAi in HEK 293 cells. These mutants will allow us to determine if RNA binding, localization or editing by ADAR1 is required for ADAR1 antagonism of RNAi. The effects on each branch of the RNAi pathway, siRNA and miRNA, will be elucidated using advanced techniques including miRNA detecting microArrays, cloning, dual-luciferase, and miRNA/siRNA reporters. Further, classical approaches of protein-protein interaction, and a recently optimized Tap-tagging approach, will be used to reveal if ADAR1 interacts directly with components of the RNAi machinery. This proposal supports collaboration between Dr. Bret Heale and Dr. Mary O’Connell. Dr. Heale received his PhD in June 2006 (USA) for his studies in the RNAi field, specifically related to siRNA and miRNA recognition of target sites, and in the course of his PhD published two first author publications (one in siRNA targeting and one in miRNA targeting) and authored a computer program to predict siRNA efficacy. Dr. Mary O’Connell (UK) has spent nearly twenty years working in the field of RNA editing, specifically examining ADARs. Thus, this proposal embodies the goals of the FP7 “People” work program to bring talented scientists to Europe, further European science, and to strengthen international ties.

Keywords: rna editing,adenosine deamination,rnai,rna interference,sirna,mirna
Fuel Cell Membranes Based on Functional Fluoropolymers (FLUPOL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-05-01
End date: 2010-04-30
Duration (months): 24.0
Total project cost (EUR): 169957.94
EU funding (EUR): 169957.94
Participants: 1
Project status: CLOSED

Several research groups are focusing their efforts on the replacement of the most widely used perfluorinated Nafion® as Proton Exchange Membrane Fuel Cell (PEMFC). The objective of this proposal is to prepare new fluoropolymers for fuel cell membranes. The physico-chemical and electrochemical properties of these new polymers will be rigorously assessed. The methodology relies on the use of novel fluorinated monomers [such as α-fluoromethylstyrene] and their radical copolymerisation with various alkenes [chlorotrifluoroethylene, para-(2,2-dimethylisocyanate)styrene or vinylene carbonate]. This proposal builds on an existing collaboration between Gouverneur and Ameduri who have expertise on synthetic fluorine chemistry and polymer chemistry, respectively.

Keywords: polymer chemistry,organic chemistry
New computational tools for the modelling of correlations in quantum systems. (QUANTUM MODELLING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-12-01
End date: 2010-11-30
Duration (months): 24.0
Total project cost (EUR): 207317.11
EU funding (EUR): 207317.11
Participants: 1
Project status: CLOSED

The aim of this project is to use insights from exactly solvable models in order to improve the accuracy of quantum Monte Carlo methods for the modelling of correlated quantum systems such as ultracold atomic gases, nuclear matter and non-conventional superconductors. This will lead to a more precise understanding of the quantum correlations that exist in such systems and will allow to extend these insights to nuclear matter, neutron-rich atomic nuclei or neutron stars. The project also aims to clarify the relation between these systems and recent experiments on ultracold atomic gases. Through the development of new numerical simulation techniques the project will have considerable impact on the fields of nanotechnology (high-Tc superconductors, carbon nanotubes), quantum computing, nuclear waste transmutation and nuclear energy production.

Keywords: atomic physics,nuclear physics,computational physics