Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Social Capital, Institutional Accessibility and Local Governance (socialog)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-04
End date: 2018-01-03
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The research proposal focuses on the study of the interaction between individuals' accessibility in contemporary institutions and their Social Capital (SC). The main premise of the proposal is that alienation from formal institutions creates a form of SC that works in a substitutive rather than a complementary way with the institutions and does not necessarily have positive societal externalities. In the first phase of the fellowship, a multi-disciplinary and innovative methodology will be applied in order to determine the exact conditions under which this form of SC is being developed and to measure the externalities it yields in a societal level. The second phase of the fellowship is devoted in exploring the implications of the results for local governance policy-making. In particular, it involves disseminating the findings and insights of the study to a Think Tank whose objective is advising local government councils.

Keywords: social capital,institutions,behavioral economics,survey
Unmanned Chemical Lab (UCL): autonomous control system for the remote management of soluble and emulsifiable metalworking fluids (UCL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Several industries such as transportation, machinery and metal fabrication rely on metalworking fluids (MWF) for smooth operation. Water-based MWF, especially emulsions are susceptible to deterioration due to factors such as bacterial growth or evaporation of water which alter the fluid characteristics. In order to keep MWF properties at their optimum, additives must be used. Currently, however, testing of parameters is done either once a week using hand-held devices or using automatic systems which send information to operators alerting them to intervene. If additives are not poured in time, the MWF become unusable and need to be disposed. MWF disposal is associated with high costs of waste management and negative environmental impacts. In addition, both MWF and additives pose health risks such as skin reactions and respiratory conditions. REYS S.p.A, an expert chemical production and fluid management company has developed the Unmanned Chemical Lab (UCL), a cloud-based platform that automatically predicts fluid degradation events, remotely manages and controls process fluids reducing drastically the health exposure risk to workers. Based on an extensive database on MWF parameters and interventions taken by operators, our system has an artificial intelligence (AI) software capable to determine the amount of additives required to restore parameters to their optimum and pours the measured additives automatically. UCL novelty relies on four major pillars: (1) AI powered software enables continuous, automatic and highly accurate monitoring of the emulsion providing correction of MEW parameters in real-time; (2) usage of less than 2% fluids and additives; (3) reduce MWF disintegration by 100% enabling the fluid to last its full-service life of a year and (4) 100% reduction of health and safety operator risks associate with in situ MWF measurements. We foresee to generate a cumulative profit of €2.4M, a ROI of 4.45 and +12 personnel, 5 years post commercialisation.

Keywords: metalworking fluids,remote control fluid assessment,remote sensors,artificial intelligence
Penetration-promoting and Imageable Polymeric Micelles as a Platform Technology for Individualized and Improved Tumor-targeted Drug Delivery (PIcelles)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-10-01
End date: 2020-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

PIcelles will assess the commercial viability of a novel theranostic nanoformulation for anticancer therapy. Current nanomedicine platforms are not able to boost response rates and survival times due to two main reasons: (1) the high variability in the accumulation of nanomedicines in tumors and metastases; and (2) the poor tissue penetration of nanomedicines in tumors and metastases. Based on results of the ERC project NeoNaNo, we are developing an imageable and penetration-promoting PIcelles platform, which is based on polymeric micelles, that will tackle these challenges by incorporating three key features in one formulation: (1) chelators for radiolabeling, to enable patient pre-selection via non-invasive imaging of target site accumulation; (2) a novel peptide on the micelles’ shell, to allow for active targeting to the microenvironment in tumors and metastases, and also for active pharmacological promotion of nanomedicine penetration; and (3) facile, efficient and stable drug loading, with clinically relevant anticancer agents. In this project, we aim to generate technical and commercial proof-of-concept for our proprietary PIcelles platform technology, enabling us to enter into license deals with large pharmaceutical industries that are in need of novel breakthrough drug delivery technologies for their difficult-to-formulate anticancer agents.

Keywords: theranostic,nanomedicine,cancer,platform,tumour
Supporting and promoting responsible research and innovation in ICT (RRI-ICT Forum)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Italy,Austria,Italy,Slovenia,Belgium,France,United Kingdom
Call: Human-centric Digital Age (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 999750.0
EU funding (EUR): 999750.0
Participants: 7
Project status: CLOSED

The RRI-ICT Forum proposal aims at monitoring, analyzing, supporting and promoting SSH contribution to, and RRI approach in ICT research and innovation under H2020. The consortium approach is to constitute a team curating the RRI-ICT domain in H2020 without prejudice (not aiming at imposing its own views or agenda, but at facilitating community views and agenda), and empowering other projects and the European Commission (as an active interface between projects and DG Connect). The project intends to reach the highest impact, within its 3-year project period and beyond, through the following activities: • Development of a concertation mechanism involving the ICT 31 RIAs, • Active interaction with other RRI / SSH project: ICT-related projects developing under the LEIT ICT WP or other pillars of H2020, non ICT-related RRI H2020 projects, RRI-ICT projects outside H2020, • Development of an open online community platform devoted to RRI in ICT, • Organization of Annual RRI-ICT Forums, multi-faceted and multi-disciplinary events open to research organizations and any stakeholders interested in the RRI-ICT topic, • Preparation of Annual RRI-ICT reports synthetizing the information collected through all project activities, analyzing the emergence of RRI in ICT, highlighting success stories, identifying best practices, deriving policy recommendations, etc., • Development of a RRI-ICT Forum website and of related social networks, including specific content targeting the public at large, • Contribution to conferences and publications, • Implementation of measures ensuring the sustainability of project activities, namely of the community platform, the website and the annual forums, beyond the project period. The RRI-ICT Forum consortium is composed of a multi-disciplinary group of complementary organizations, with proven expertise and strong references in the ICT, SSH and RRI domains, and a longstanding experience in developing the types of activities planned in the project.

Keywords: forum,collaboration,platform,policy,recommendations,community
Entrapment of Hypoxic Cancer by Macrophages Loaded with HAP (McHAP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Poland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 1413750.0
EU funding (EUR): 1413750.0
Participants: 1
Project status: CLOSED

The proposed project seeks to open a new research front within the field of drug delivery to the solid tumours. Unsatisfactory response of tumours to chemotherapy is mainly related to impaired diffusion of the anticancer drug because of decreased drug uptake due to poor vasculature. Moreover, the drug is not able to penetrate the most hypoxic sites. Cells from these ‘untreated’ sites are responsible for relapse and metastasis. However, these avascular regions attract macrophages that migrate even to areas far away from blood vessels. Therefore, they might constitute a unique delivery system of drug containing particles to these parts of the tumour mass. A promising example of such particles that could be used are ferritins, whose caged architecture allows for efficient drug encapsulation and whose uptake from macrophage cells has been well demonstrated. My recent ground breaking finding was that macrophages are also able to specifically and actively transfer these taken up ferritins (loaded with the compound of choice) to cancer cells. Thus, these preliminary results indicate the possibility to use macrophages to deliver ferritin encapsulated compounds directly to the tumour cells even in its hypoxic areas. Then, the use of hypoxia-activated prodrugs (HAP) which are selectively activated only in hypoxic regions will be exploited in order to make cancer therapy safer. However, the molecular mechanism of ferritin uptake by macrophages, their storage, and transport to the cancer cells represent key issues to be investigated and pave the way to the experimental design of the present project. In the present project, we will develop and characterize a completely new and modern approach to anticancer therapy and drug delivery. As such we expect to be able to precisely administer drugs to the tumour site (even to the hypoxic regions) where it is activated by tumour-specific conditions, avoiding side effects of anticancer therapy.

Keywords: cell based delivery system,ferritin,macrophage,cancer
Cybersecurity in the RAILway sector (CYRail)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Germany,Spain,Sweden,France,France,Portugal
Call: Threat detection and profile protection definition for cyber-security assessment (H2020-S2RJU-OC-2015-01-2, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 1498150.0
EU funding (EUR): 1498150.0
Participants: 6
Project status: CLOSED

Railway infrastructures are moving towards more intelligent, connected, user-centric and collaborative systems. While it brings many advantages for the industry and users, it also poses new opportunities for cyber-criminals and terrorists. CYRail aims to deliver tailored specifications and recommendations for secure modern rail systems design and operation. The challenges are multiple: wide and distributed geographical display of rail systems limit the traditional cyber-protection and cyber-defence tools & practices; the heterogeneous nature of rail systems make them vulnerable to blended attacks; the collaboration with other transportation infrastructures increase the number of points for attack; new passenger-centric services may expose rail systems to threats known in the IoT; last but not least, ICT supporting these trends are not necessarily trusted for critical applications. CYRail will address those challenges through a methodical diagnosis and specification process, enforced at each step of the cyber-security chain: operational context and scenarios will be defined, followed by a security assessments of railway systems. An analysis of threats targeting those infrastructures will be developed as well as innovative, attack detection and alerting techniques. Adapted mitigation plans and countermeasures will be defined, taking into account their potential impact on operations. Protection Profiles for railway control and signalling applications will be delivered to ensure security by design of new rail infrastructures. The CYRail consortium intends to take advantage of developments in other industries (aeronautics, automotive and energy) and bring them into the railway sector, taking similarities and specificities into account. The Consortium is comprised of a well-balanced group of 6 partners from 5 European countries with complementary skills. An Advisory Board is foreseen, to bring on board the expertise from stakeholders within the railway value chain.

Keywords: railways,cyber security assessment,threat detection,mitigation,countermeasures,resilience and protection profiles,security by design,control and signaling,interconnected transport
Understanding Circumventing Antibiotic REsistance (uCARE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-03-01
End date: 2024-08-31
Duration (months): 66.0
Total project cost (EUR): 1986004.0
EU funding (EUR): 1986004.0
Participants: 1
Project status: SIGNED

The evolution and spread of antibiotic resistance has become a public health concern of the utmost severity, making once treatable diseases deadly again and undermining our living standards. New therapies are imperative, but equally important are the understanding of the full repertoire of drivers of antibiotic resistance and the identification of ways to counteract them. We have recently established that ~250 non-antibiotic drugs have direct, strong and often broad antibacterial effects on human gut microbes. Moreover, preliminary data indicate that bacteria use similar general resistance mechanisms against both drugs with human targets and antibiotics. This implies that polypharmacy may be a hitherto unnoticed driver of antibiotic resistance. We will use chemical genetics and experimental evolution to systematically map the cross-resistance between human-targeted drugs and antibiotics, and elucidate underlying resistance mechanisms. Using these data, we will next seek to identify antidotes for the antimicrobial side-effects of non-antibiotic drugs, and exploit human-targeted drugs for reverting existing antibiotic resistance. At the genetic level, we will use high-throughput reverse genetics to expose the Achilles heels of bacterial cellular networks for resistance development. Finally, we will uncover the antimicrobial mode of action of tens of human-targeted drugs using thermal proteome profiling and chemical genetics. Together with the genetic information, this line of research will yield design principles and possibly new drug candidates for longer-lived, resistance-proof drug combinations. Overall, this project aims at improving our fundamental biological understanding of antibiotic resistance and the paths to prevent, delay or revert it. It can also set the basis for revisiting current medication policies. The derived principles are likely to be relevant to other diseases and therapies, in which resistance development is an issue.

Keywords: reverse genetics,chemical genetics,antibiotic resistance,microbiome,drug combinations,genetic interactions
Action-based routes for numbers: unveiling the core networks of reaching, grasping and number processing in brain damaged and healthy individuals. (GRINP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-02
End date: 2023-11-30
Duration (months): 36.0
Total project cost (EUR): 275209.92
EU funding (EUR): 275209.92
Participants: 1
Project status: SIGNED

Grasping and Reaching In Number Processing (GRINP) is focused on the study of the neural underpinnings of number processing and its impairment. Number-related deficits can dramatically affect everyday life. Nonetheless, this impairment is often marginally considered in clinical practice, possibly because the complex nature of numerical disorders makes their diagnosis and rehabilitation quite hard. GRINP builds upon action-based theories of cognition - considering many aspects of human cognition as built on motor action - and on the idea that the neural bases for abstract concepts representation are networks of functionally-related recycled mechanisms. Through a comprehensive approach which couples clinical (neuropsychological) with neuroimaging methods (magnetoencephalography), GRINP tests whether number magnitude recruits the same sensorimotor network involved in planning and executing hand movements. GRINP is timely because it relates the cognitive aspects of number and action with the study of their neural dynamics; GRINP is innovative because it promotes at different levels (scientific, clinical, societal) an action-based approach for the understanding of cognitive impairment. GRINP is based on the convergence between the solid expertise of the Fellow in numerical cognition and behavioural research methods, and the long lasting tradition of the Host in neuropsychological and neuroimaging training and research. GRINP will allow the Fellow to restart research in her native country after more than five years of international research/teaching experience and a maternity break. Thanks to the planned training on advanced neuropsychological (voxel-based lesion symptom mapping, brain tractography) and neuroimaging methods (functional connectivity) the Fellow will broaden her expertise from experimental psychology to cognitive neuroscience, putting the bases for a successful long-term career plan.

Keywords: numerical cognition,embodied cognition,mathematical cognition,acalculia,number action interaction,number impairment
Impact of Biofuels on the Oxidation Stability and Combustion Pollutants of Heavy Duty and Jet Fuels (BioSCoPe)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: France,France
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1996856.0
EU funding (EUR): 1996856.0
Participants: 2
Project status: SIGNED

Reducing greenhouse gas and harmful emissions in the transport sector is a crucial issue in the fight against climate change and air pollution. The use of sustainable biofuels remains the solution of choice to reduce the carbon footprint of propulsion systems that are difficult or impossible to electrify, such as those for aviation or road freight transports. The addition of biofuels to conventional fuels strongly affects their oxidation stability, leading to changes in their chemical and physical structures, which in turn affects the combustion engines functioning in terms of efficiency, safety and pollutant emissions. The synergistic effects of the oxidation of liquid fuels (aging), the action of antioxidant additives, and their consequences on the reactivity and pollutant emissions during their combustion remain unexplored. This project aims at promoting the development of sustainable biofuels and antioxidants for heavy-duty transports by bringing a new fundamental understanding of their coupled effects on conventional fuels, throughout all their chain of use, from storage to combustion. Unprecedented well-defined kinetic experiments to study the oxidation stability of liquid fuels will be developed and directly coupled with a gas-phase combustion reactor. Key intermediates and pollutants will be quantified in the liquid- and gas-phase reactors. Detailed kinetic models will be developed and validated for liquid-phase oxidation and gas-phase combustion, using an original approach based on theoretical chemistry for the challenging liquid-phase models. This project will set new standards in the research field of biofuel combustion properties by integrating the crucial step of fuel aging, a neglected source of pollutants. It will push the frontier of knowledge on oxidation stability of fuels and antioxidants properties, and lead to new scientific tools and concepts to understand, design and optimize biofuel/antioxidants mixtures throughout all their chain of use.

Keywords: biofuels,oxidation stability,combustion,antioxidants,chemical engineering,theoretical chemistry,kinetic model