Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Large-scale identification of secondary metabolites, metabolic pathways and their genes in the model tree poplar (POPMET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Belgium
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-07-01
End date: 2025-06-30
Duration (months): 72.0
Total project cost (EUR): 2499251.25
EU funding (EUR): 2499251.0
Participants: 1
Project status: SIGNED

Poplar is an important woody biomass crop and at the same time the model of choice for molecular research in trees. Although there is steady progress in resolving the functions of unknown genes, the identities of most secondary metabolites in poplar remain unknown. The lack of metabolite identities in experimental systems is a true gap in information content, and impedes obtaining deep insight into the complex biology of living systems. The main reason is that metabolites are difficult to purify because of their low abundance, hindering their structural characterization and the discovery of their biosynthetic pathways. In this project, we will use CSPP, an innovative method recently developed in my lab, to systematically predict the structures of metabolites along with their biosynthetic pathways in poplar wood, bark and leaves. This CSPP method is based on a combination of metabolomics and informatics. In a next step, the CSPP tool will be combined with two complementary genetic approaches based on re-sequence data from 750 poplar trees to identify the genes encoding the enzymes in the predicted pathways. Genome Wide Association Studies (GWAS) will be made to identify SNPs in the genes involved in the metabolic conversions. Subsequently, rare defective alleles will be identified for these genes in the sequenced population. Genes identified by both approaches will then be further studied either by crossing natural poplars that are heterozygous for the defective alleles, or by CRISPR/Cas9-based gene editing in poplar. The functional studies will be further underpinned by enzyme assays. Given our scarce knowledge on the structure of most secondary metabolites and their metabolic pathways in poplar, this large-scale identification effort will lay the foundation for systems biology research in this species, and will shape opportunities to further develop poplar as an industrial wood-producing crop.

Keywords: poplar,biochemical pathways,metabolomics,gwas,genome sequence,reverse genetics
Integrating Environment and Health Research: a Vision for the EU (HERA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Coordination and support actions
Countries involved: Austria,Ireland,Germany,Spain,Belgium,Greece,Sweden,Poland,Switzerland,Belgium,Finland,Slovenia,France,France,France,Czechia,Netherlands,United Kingdom,Portugal
Call: Setting the priorities for a European environment, climate and health research agenda (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2022-03-31
Duration (months): 39.0
Total project cost (EUR): 3097322.5
EU funding (EUR): 3097322.5
Participants: 27
Project status: CLOSED

Environmental degradation and pollution, climate change, and the destabilization of the ecosystem biodiversity, damage health and quality of life, and affect socially disadvantaged and vulnerable populations. Negative outcomes can be balanced by positive effects that healthy environments, such as green and blue spaces, can have on human and ecosystem health. Socio-economic costs are significant and public policies could develop preventive actions. HERA will set the priorities for an environment and health research agenda in the EU by adopting a holistic and systemic approach in the face of global environmental changes. Research will support decision-making and help attain the ultimate goal of protecting and improving ecosystem quality and human health. HERA will identify both the environmental opportunities for health improvements and the major environmental problems and challenges. This ambitious objective will only be possible through a close and continuous interaction with numerous and diverse stakeholders in the wider environment and health area. HERA specifically aims: 1) to proactively identify key sectors and policy areas in the field of environment and health that will benefit from additional scientific evidence in the next decade; 2) to develop a European medium-term research and innovation agenda covering key strategic research and policy aspects; 3) to propose strategies and tools to respond to the new and continuing challenges in environment and health nexus, by ensuring the engagement of stakeholders, increasing coordination and cross-fertilisation of ideas, and contributing to the European environment and health process and policy activities. HERA is structured in workpackages addressing policy needs, knowledge gaps, establishment of new guidelines, stakeholder community consultation and establishment of the research agenda. A specific activity focuses on knowledge transfer towards countries with less active research in environment and health.

Keywords: pollution,contaminants,climate change,health impact assessment,exposome
Light and Organic Nanotechnology for Cardiovascular Disease (LION-HEARTED)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Spain,Italy,Italy,Italy,Spain,Italy
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2018)
Start date: 2019-05-01
End date: 2023-10-31
Duration (months): 54.0
Total project cost (EUR): 2904413.75
EU funding (EUR): 2904413.75
Participants: 9
Project status: SIGNED

Cardiovascular (CV) disease is the leading cause of mortality and morbidity worldwide, with an increasing incidence in the aging population and a huge socio-economical impact. Heart failure (HF), the common end point of virtually all CV disorders, displays the greatest negative impact on quality of life, leading to the disruption of daily management and increasing dependence on care-givers. Unfortunately, an effective pharmacological treatment is currently lacking, as it is not possible to reverse disease progression; as a consequence, the long-term survival remains poor, and heart transplantation is the only possibility for end-stage HF patients. Thus, a breakthrough approach to preserve or, at least, restore cardiovascular function and to rescue systemic blood perfusion is urgently required. LION-HEARTED will demonstrate a novel optoceutic platform, based on synergistic combination of light and organic nanotechnology, to restore cardiac function and vascularization, by modulating fate and proliferation of main cardiovascular cell types. Optical modulation will provide unprecedented spatio-temporal resolution, lower invasiveness, and higher selectivity in respect to traditional electrical and pharmaceutical control methods. Organic semiconductors will act as efficient, highly biocompatible phototransducers, able to trigger biological pathways relevant to cardiac repair, with a minimally invasive and gene-less approach. This strategy will circumvent most of the hurdles currently limiting the efficacy of molecular therapies, by directly stimulating the reparative phenotype of resident cardiac progenitors, cardiomyocytes, and of circulating endothelial cells homing towards the heart after an ischemic insult. The final outcome will be the realization of a proof of concept, implantable device for enhancing cardiac repair in ischemic, aneurysm and stenosis in vivo animal models.

Keywords: bio organic electronics,cell optical stimulation,conjugated polymer,organic semiconductor,light
Unlocking mobility for everyone (UNITE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-06-01
End date: 2022-09-30
Duration (months): 28.0
Total project cost (EUR): 3077170.0
EU funding (EUR): 2154019.0
Participants: 1
Project status: CLOSED

Karos was founded in 2014 to leverage collaborative consumption and artificial intelligence in order to revolutionize suburban areas commuting services and offer a disruptive transportation service to commuters. Karos innovativeness finds its sources in the advantages from both carpooling and public transportation: collaborative consumption for public services and a mix of social, professional and public networks. The Karos solution extends the current public transportation network with unbeatable performances: a network extension & densification by a factor of 10 and a transport cost divided by 10. Having raised over 7.5 M€, the Company’s mission is to develop disruptive AI technologies to transform empty car seats into sustainable and low-cost-to-operate public transportation networks in low density areas. Karos solution unlocks mobility thanks to 4 main pillars: Artificial intelligence, Intermodality, an innovative business model and an approach to change Users’ mobility habits. Unlike traditional carpooling players, KAROS is based on a public-transportation-like business model applied to carpooling activities (a multi-stream revenue generation). The solution is distributed through two product lines: Karos Territories for Local transportation Authorities, and Karos Enterprise for companies willing to improve their employees wellbeing. The EIC accelerator will be a unique opportunity to make a next step in the system with another 3 M€ of technical development and accelerate the time-to-market in Europe with a marketing and sales plan of 3.2 M€. The UNITE project will enable KAROS to recruit 500 000 new users and sign 10 new contracts with smart cities and with over 550 large corporations in order to achieve a revenue over 100 M€ by 2024. KAROS UNITE is a 6.3 M€ project, with a funding split between a Grant of 2.1 M€ and 3.2 M€ in equity.

Keywords: carpooling,maas,urban transport,shared mobility,public transport,air pollution,carbon reduction,collaborative consumption,public sector innovation,social innovation
A topological approach to electron correlation in density-functional theories (topDFT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-05-01
End date: 2024-04-30
Duration (months): 72.0
Total project cost (EUR): 1998649.0
EU funding (EUR): 1998649.0
Participants: 1
Project status: SIGNED

Density-functional theory (DFT) is the most widely used method to study the electronic structure of complex molecules, solids, and materials. Its use across chemistry, solid-state physics and materials science is a testament to its black-box nature and low cost. However, many important areas remain inaccessible to DFT simulations, including applications to strongly correlated materials and systems in electromagnetic fields. The topDFT project will deliver new conceptual approaches to design the next generation of density-functional methods. This will be achieved by pursuing three parallel strategies: i) Developing new strategies for the design of functionals ii) Implementing topological DFT, a new computational framework iii) Developing extended density-functional theories. A new approach to the exchange–correlation problem, based on a perspective from the kinetic energy of the electrons, will be developed – leading to new practical density-functional approximations (DFAs). A new framework for computation will be developed by combining techniques from topological electronic structure methods with DFT, allowing for the identification of correlation ‘hotspots’. This idea is chemically intuitive; electrons close together interact in a fundamentally different way to those far apart. Recognising these hotspots, and adapting dynamically to them, will lead to new DFAs with substantially greater accuracy. Extended-DFTs will open the way to study strongly correlated systems (e.g. high-Tc superconductors, transition metal oxides, Mott insulators) of importance in chemistry and materials science and magnetic systems (e.g. molecular magnets, spin glasses, spin frustrated systems) of importance in nano-science, advanced materials and spintronics applications. The topDFT project will have wide impact on areas including chemical synthesis, materials design and nano-science that underpin key areas such as manufacturing and medicine of benefit to all sections of society.

Keywords: electronic structure theory,density functional theory
Helix Nebula – The Science Cloud (HNSciCloud)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: COFUND actions
Countries involved: Germany,Germany,Germany,Spain,Italy,Switzerland,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Boosting public sector productivity and innovation through cloud computing services (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 6770127.0
EU funding (EUR): 4716374.0
Participants: 13
Project status: CLOSED

Over the coming 10-15 years the generation of vast amounts of data created by scientific research domains will create enormous challenges for capturing, managing and processing of this data. Tests have been made but today commercial cloud services do not play a significant role in the production computing environments for the publicly funded research sector in Europe. Stimulated by the Pre-Commercial Procurement (PCP) commitment of leading research organisations from 7 countries, HNSciCloud will pull together commercial cloud service providers, publicly funded e-Infrastructures and the buyers’ in-house resources to build a hybrid cloud platform on top of which a competitive marketplace of European cloud players can develop their own services for a wider range of users. This project will bring Europe’s technical development, policy and procurement activities together to remove fragmentation and maximise exploitation. The alignment of commercial and public (regional, national, and European) strategies will increase the rate of innovation. Through a competitive series of design, prototype and pilot steps, HNSciCloud will contract suppliers to deliver a 5% scale deployment of a hybrid cloud platform that can address the extreme needs of world class scientific research, including: • Catalog of secure and interoperable services from multiple suppliers that have successfully passed an international recognised certification process • Agile procurement process suitable for the dynamic cloud services market and tailored to the needs of the public research sector • Development of monitoring frameworks to ensure compliance with international security and interoperability standards, performance criteria and financial benchmarking against global market leaders. The resulting common platform will be evaluated by end-users and exploited as the incubator for new businesses and scientific activities engaging a growing number of buyers, suppliers & users.

Keywords: procurement,einfrastructures,tendering,science
ADDACT - Fanpowered Concerts (ADDACT GmbH)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Germany
Call: SME business model innovation (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The global ticket market for live music concerts totally missed the digital transformation: 1. About 50% of concert tickets remain unsold 2. Immense inefficiency within the whole industry remain unsolved: - a lot of small, regional, intransparent parties and networks - no reliable data about real demand for artists in various cities – bands keep playing in the same cities - concert planning still based on experience and estimates – Promoters do not know if their shows will even cover the production costs - fans are totally out of the tour planning process - no satisfying technological solution to the raising demand for fan participation (while Social Media channels are not capable of this problem) ADDACT is a total new way of planning live concerts and distributing tickets and will cope with these global challenges. On ADDACT fans can pledge for their favourite tour cities by giving binding ticket orders. The cities with the most demand will get a show. ADDACT combines ticketing and crowdfunding so fans can actively influence the tour dates of their favourite bands. Bookers, promoters and managers can plan concerts meeting the actual demand and with much less financial risk. Bands, on the other hand, play more concerts in various cities for a bigger audience and create a much deeper relationship towards their fans by giving them influence. Goals of Feasibility Study: - Evaluate three different ways of fan participation for further development of ADDACT model - Drive test campaigns in new markets - Evaluate commercial potential of the live music industry in UK, Benelux and Scandinavia - Derive business plan, future price model and strategic road map

Keywords: ticket distribution crowdfunding music industry
Materializing Modernity - Socialist and Post-socialist Rural Legacy in Contemporary Albania (MaMo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Albania
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 137679.36
EU funding (EUR): 137679.36
Participants: 1
Project status: SIGNED

MaMo is a research project that focuses on Socialist rural architecture and landscape and its Post-socialist legacy in the Albanian countryside, aiming at (1) investigating how the communist ideology materialized in the Albanian rural territorial and architectural planning; (2) analysing the current condition of the former agricultural cooperatives and state farms settlements and how they relate with the compelling informal post-socialist transformation; (3) proposing a multi-level and interlaced understanding of Socialist modernism and its contemporary transformation through local rural communities perceptions and experiences. Further, by producing a novel scientific contribution in the academic research fields of contemporary ethnography and anthropology, modern architecture and landscape planning and history, and critical cultural heritage studies, MaMo intends (4) to constitute a national and international platform to discuss and place for the first time Albania in the framework of European studies on modernist rural architecture and landscape. In fact, as for many European states during the 20th-century, Socialist Albania planned, adopted and implemented large scale development and agricultural plans to modernize its rural areas. Crucial to the nation and state-building policies, those plans provided a trial opportunity for new landscape and architecture ideas converging on the vision imposed by the regime. Through a multidisciplinary research-through-training approach based on the collection, processing, and critical interpretation of visual data and multiple narratives, MaMo will systematically explore and document for the first time the Socialist modern rural architecture and its Post-socialist legacies in the Albanian countryside.

Keywords: socialist modernization processes,rural architecture and landscape,collective cooperatives and state farms,rural communities,urbanization,socialist legacy,post socialist evidence,albania
Hybrid power-energy electrodes for next generation lithium-ion batteries (Hydra)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Germany,Belgium,Sweden,Norway,Romania,Norway,Norway,France,France,United Kingdom
Call: Research and innovation for advanced Li-ion cells (generation 3b) (H2020-LC-BAT-2019, 2019)
Start date: 2020-05-01
End date: 2024-08-31
Duration (months): 52.0
Total project cost (EUR): 9401701.25
EU funding (EUR): 9401701.25
Participants: 13
Project status: SIGNED

The core technological approach of the HYDRA project consists of using hybrid electrode technology to overcome the fundamental limits of current Li-ion battery technology in terms of energy, power, safety and cost to enter the age of generation 3b of Li ion batteries. HYDRA, taking its name from the mythological beast, will use a multi-headed integrative approach: In addition to novel material development and scale-up of components and battery cells manufacturing, assisted by modelling, HYDRA will build a synergy with strong investments by the project’s industrial partners and foster reaching and keeping a significant market share for Europe. The necessary competitiveness will be obtained by hybridizing high energy with high power materials. These materials will be implemented at the cell/electrode level, via sustainable, eco-designed scaled-up manufacture and safe electrolyte systems, demonstrated in pilot scale to TRL6, and will be ready for commercialisation 3 years after the project end. To reach this target, HYDRA mobilizes a strong industry commitment: the partners include a strong value-chain of suppliers with global competitiveness for xEV batteries and a direct liaison to the market in sectors such as automotive and maritime transport, ensuring a fast-uptake of results, with an added value of 1BN € in the next decade. Ecological and economical sustainability also keep a strong importance, as HYDRA will be performing life cycle assessments and value-chain analyses on local and global scales. All aspects from raw materials via battery cell production and end-use/market to recycling and 2nd life usage will be evaluated. The HYDRA concept uses abundant electrode materials like iron, manganese and silicon, and eliminates the use of the CRMs cobalt and natural graphite, with a net CRM reduction of >85%. The new materials will be produced in an environmentally friendly, energy-efficient manner, and using water in place of organic solvents.

Keywords: hybrid electrodes