Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A novel modular energy generation, storage and power management solution (NanoDeck)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The shipping industry is in dire need of reducing its carbon emissions. As one of the toughest industrial sectors to clean up, shipping currently accounts for about 3% of global carbon pollution. However, without changes this could balloon to over 10% of worldwide emissions by 2050 - an environmental disaster. It is apparent that ships present unique challenges for switching to renewable energy. This is because of their huge power demands as they need colossal amounts of energy at all times, even when traveling the globe non-stop for long periods. Retrofitting existing vessels is also difficult as they have little space beyond what is needed for cargo. Moreover pressures are also ever mounting as regulations from both the IMO and EU tighten to drive faster emission cuts. This confluence of factors results in a trifecta of pain points severely impeding shipping’s transition to greener technologies. We aim to tackle fleet decarbonisation barriers with our market-defining patent protected renewable solution NanoDeck. Using modular power hubs, distributed energy harvesting, and smart optimization, NanoDeck is a customisable solution that can stealthily integrate renewables into any vessel by converting any flat surface into clean energy generator. The EIC funding will be key to validating NanoDeck’s viability. The piloting will demonstrate the innovative twinning of renewables and storage as presented by NanoDeck is the preferred long-term energy model for a sustainable shipping future. Cementing NanoDeck’s industry-shaping potential during this validation phase brings us one step closer to fully realising our ambitious mission - empowering emissions-free, clean energy-powered maritime operations worldwide.
Decarbonising industry with Renewable Natural Gas (Turn2X)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Germany
Call: Renewable energy sources and their whole value chain including materials development and recycling of components (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-10-01
End date: 2026-12-31
Duration (months): 27.0
Total project cost (EUR): 3478750.0
EU funding (EUR): 2435125.0
Participants: 1
Project status: SIGNED

The threat of climate change is pushing every sector of the economy to decarbonise its operations, but certain hard-to-abate sectors, such as heavy industry, gas utilities and shipping, cannot easily switch to renewable energy sources. Electrification is not feasible for these sectors and switching to alternative energy sources would require huge investment in new equipment, process changes, and civil infrastructure. This places many Net Zero targets at risk. Turn2X aims to rapidly decarbonise these sectors using renewable natural gas (RNG), a green energy source that can replace fossil natural gas in hard to abate sectors and enable rapid decarbonisation without the large infrastructural changes needed for other solutions. Our patented honeycomb reactor utilises green hydrogen and biogenic CO2 to create RNG. This is chemically identical to fossil-methane and is 100% drop in ready with existing natural gas pipelines and can be used wherever fossil natural gas is used today. This means no large CAPEX investments are required on the customer side, as they can continue using their existing burners or furnaces. The superior heat removal properties of the reactor, simplifies the heat management system of the plant. This as well as the use of the standardised modular parts and the reduction of the plant size compared to competitor plants allow us to reduce the CAPEX of RNG plants by around 30%. Turn2X also boasts the fastest ramp up time which is critical when using renewable energy sources with fluctuating energy loads and enables operation at times of peak energy when costs are lower. Overall, this leads to a lower cost for RNG, which is competitive with biomethane today and will reach price parity with fossil natural gas in the long term. In line with the RePowerEU plan, Turn2X are offering a possibility to reliably and cost-effectively produce renewable natural gas within Europe.

Keywords: hydrogen,electrolyzer,methanation,natural gas,net zero,ghg avoidance,renewable hydrogen,energy transition,energy security,renewable natural gas,sng,rng,methanation,deacarbonisation
Theatre, Healing, and Epiphany in the Ancient Mediterranean (THEAM)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Greece
Call: ERA Fellowships (HORIZON-WIDERA-2023-TALENTS-02, 2023)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 153486.72
EU funding (EUR): 153486.72
Participants: 1
Project status: SIGNED

Concepts of medicine, health, and healing are now at the core of the global agenda due to the recent pandemic. In this context, a better understanding of the intangible cultural heritage of ancient and indigenous medical cultures is crucial. It is often assumed that contemporary European culture derives from the Ancient Greco-Roman one, but if we turn to core values such as health and healing we find out that in Greco-Roman antiquity they are much more comparable to many contemporary non-Occidental cultures than to the Western bio-medical paradigm . Dreams and visions were strongly connected to these concepts as they were used in the ritual of incubation, which brought devotees into visionary contact with the invisible to obtain healing or prophecies. Incubation was the distinctive feature of the cult of Asklepios, the Greek god of medicine. THEAM explores the relationship among dramatic performance, healing, and epiphany by contextualising such practices within the cultures of ancient Mediterranean. How did ritually-induced epiphanies spread in the Mediterranean as a tool for healing? What agency did thousands of unknown worshippers have in the dissemination of these ritual gestures? How are these ritual practices embedded in the design of sanctuaries and theatres? What was the role of islands in this historical phenomenon? How do this ancient practices relate to nowadays concepts of healing and health? The case studies are the island sanctuaries of Asklepios in Sicily, the Cyclades, and Crete. Ultimately, THEAM represents a valuable contribution to our understanding of ancient religious practices, their evolution, and their socio-economic implications. It offers a platform for innovative medical approaches that harness the power of performance as a therapeutic tool, such as psychodrama and psychotheatre, further enriching our comprehension of the intersections between ancient religion, medicine, and society.

Keywords: healing ancient religion theatre archaeology of cult practices ancient economy
POLiN: the POlitical conditions of Interoperability in European digital health policies (POLiN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-15
End date: 2026-03-14
Duration (months): 29.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

The POLiN project’s aim is to explore the political condition of interoperability in European digital health policies. ‘Interoperability’ refers to the ability of computer systems to work together, even if they are created by different business or state organizations. Interoperability standards are key to the creation of efficient digital health infrastructures, in particular at the European level. For instance, Electronic Health Records are expected to be available everywhere in the European Union, flowing within a harmonized ‘European Health Data Space’. If the technical conditions of interoperability have been extensively explored, little is known about the political conditions under which various actors pursuing complex agendas may be willing to adopt common standards. Indeed, standard selection in digital health is guided by many different industrial, medical, political, legal, and ethical considerations. Therefore, the aim of this project is to explore the political conditions favoring or impeding the adoption of interoperability standards in EU digital health. As digital cooperation marks a turning point for the future of EU integration, this proposal will contribute to open a new research agenda, aiming to explore how the EU is able to govern through project cooperation. Furthermore, interoperability choices reflect highly sensitive and political decisions which are not trivial and are likely to deeply transform the lives of EU citizens. This project therefore intends to contribute to the adoption of better, inclusive digital health standards. This MSC fellowship will be key in strengthening my skills in European studies, as I will be guided by a renowned expert in European decision-making processes, Prof. Stephanie Novak. In addition, the host institution, Ca’ Foscari University, will provide me with many opportunities to acquire new transferrable skills and to develop the interdisciplinary aspect of my research.

Keywords: european governance digital health cooperation interoperability european health data space
Glycosaminoglycan biosynthesis: deciphering the divergent step (GlycoDIVE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 3
Project status: SIGNED

Glycosaminoglycans (GAGs) are negatively charged polysaccharides that form a key part of the extracellular matrix in animal tissues, from marine corals to humans. They play crucial roles in cell signaling, mediating processes such as embryonic development, cell growth and proliferation, cell adhesion, anticoagulation, and wound repair. Given their diverse functions, GAG dysregulation is linked to various medical conditions, including neurological, cardiovascular, infectious, and inflammatory diseases, as well as diabetic complications and cancer. While much is known about their roles in health and disease, gaps remain in understanding of how they are synthetized in human tissues. This project aims to investigate glycosyltransferases that participate in the synthesis of heparan sulfate and chondroitin/dermatan sulfate at a molecular level. By integrating biochemistry, structural biology (including cryo-electron microscopy and X-ray crystallography), and cell biology, our goal is to uncover the molecular mechanisms that distinguish these polysaccharides. Thus, this project aims to address fundamental questions in GAG biosynthesis and to provide a molecular basis for the development of GAG-based therapies in future studies.

Keywords: glycosaminoglycan,proteoglycans,glycosyltransferases,heparan sulfate,chondroitin sulfate,dermatan sulfate
Arctic glacier melting in warming climates: a new biogeochemical proxy for glacial discharge using Ba/Ca in benthic foraminifera (GMPro)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway,Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 251578.56
EU funding (EUR): 251578.56
Participants: 2
Project status: SIGNED

The Arctic is warming at an unprecedented rate, leading to rapid glacier retreat and accelerated melting of the Greenland Ice Sheet. This has far-reaching consequences: rising sea levels, changing ocean geochemistry, and the amplification of global warming. Environmental and socioeconomic effects are already becoming evident, extending from the mid- to high latitudes. Nevertheless, uncertainties in the outcomes and severity of these changes persist due to our limited understanding of long-term glacier dynamics and their natural variability. Such can be gained from marine sedimentary records, given reliable proxies are available. GMPro will establish a novel biogeochemical indicator for past glacial meltwater discharge, based on barium-to-calcium ratios (Ba/Ca) in shells of benthic foraminifera. Combining modern calibrations and paleo studies in two key Arctic regions (Greenland, Svalbard), this project will (1a) establish barium pathways in fjords across spatial and temporal gradients of glacier melting and (1b) trace barium uptake into foraminifera shells using state-of-the-art micro-analytical techniques; (2) validate the new proxy against multiple established glaciological and oceanographical indicators; and (3) unlock histories of Arctic deglaciation under past, warm(-er than today) climates. The outcomes will enhance our understanding of glacier dynamics under a changing climate, and form the foundation for refining climate models, predicting future changes and supporting evidence-based adaptation strategies. Through GMPro, I will gain skills and experience in Arctic paleoclimatology and -oceanography, receive focused training in research leadership and management, and build an extensive network for future collaborations. These combined will be my steppingstone to becoming an interdisciplinary, independent and leading researcher within Arctic paleoclimatology and geochemistry.

Keywords: proxy development,trace elements,foraminifera,arctic,glacier melting,greenland ice sheet,holocene,paleoceanography,micropaleontology,multi proxy
Changing the tempo of neuronal development to modulate neural circuit function and plasticity (TEMPOPLAST)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

The timing of neuronal development is highly variable depending on the cell type or species. In particular human cortical neurons display a considerably protracted tempo of development, at the basis of human brain neoteny. The mechanisms underlying neuronal neoteny start to be unravelled, but their significance for brain function and plasticity remain poorly known, despite their implications for brain diseases and repair. This project will combine innovative technologies developed by the applicant and the host lab, including brain transplantation, molecular manipulation of developmental tempo, and neural connectivity. Taking advantage of recent findings of the host lab that link metabolism to neuronal maturation speed, we will manipulate mitochondrial function to accelerate the maturation of human neurons in a xenotransplanted mouse model, and conversely, to decelerate murine neurons within the mouse visual cortex. We will thus examine how increasing or decreasing neuronal maturation rates influence functional development, synaptic functions, and experience-dependent plasticity, across time and species. Using advanced techniques including electrophysiology, in vivo calcium imaging, and monocular deprivation neural plasticity paradigms, we will explore the impact of neuronal developmental tempo on cortical circuit function and plasticity. Finally and most excitingly we will use the same paradigms to investigate whether transplanted juvenile neurons can induce plasticity in the neuronal networks of the adult host brain. Additionally, chemogenetic and transsynaptic tracing approaches will dissect potential mechanisms underlying the observed effects. Using MERFISH spatial transcriptomics, we aim to unveil molecular programs driving plasticity induction. This project holds significant potential to reshape our understanding brain development and plasticity, and its implications for neurodevelopmental diseases and therapeutic interventions in the ageing brain.

Keywords: neuronal plasticity,heterochronic networks,human brain neoteny,neuronal maturation rate,xenotransplantation,monocular deprivation,two photon calcium imaging
Democratising jUst Sustainability Transitions (DUST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Netherlands,Poland,Switzerland,United Kingdom,Sweden,Bulgaria,Germany
Call: The future of democracy and civic participation (HORIZON-CL2-2022-DEMOCRACY-01, 2022)
Start date: 2023-02-01
End date: 2026-01-31
Duration (months): 36.0
Total project cost (EUR): 2687214.4
EU funding (EUR): 2687214.39
Participants: 13
Project status: SIGNED

The DUST project will develop and operationalise novel participatory instruments for proactive and strategic citizen engagement in sustainability transitions. It will combine design-led territorial tools with digital tools for citizen deliberation at scale. The project addresses a defining societal and democratic challenge for Europe, which is to hear the voices of least engaged communities, especially in structurally weak regions dependent on energy-intensive industries, which will be most affected by transitions towards a more sustainable future. Building on the concept of ‘active subsidiarity’, the project will employ an innovative mix of research methods, and experimental citizen participation, to understand the determinants of participation in decision-making on sustainability transitions at different levels of government, and to develop effective policy recommendations for inclusive engagement of civil society.

Keywords: sustainability transition,deliberative governance,place based policy,spatial planning,active subsidiarity,least engaged communities,e democracy,futures literacy,foresight,regional design
Remote controlling biological systems by sonopharmacology and sonogenetics (SONOPHARMAGEN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

To date, light has been employed as a widespread trigger to achieve control over the activity of drugs and protein function establishing the fields of photopharmacology and optogenetics, respectively. Both techniques led to promising new therapies, the elucidation of brain function or understanding of neural disorders. However, serious limitations resulting from the low penetration depth of light into tissues are severely hampering progress in these fields. In contrast to photons, ultrasound deeply penetrates tissue and can be applied with sub-millimeter resolution and consequently has been widely established in the clinic over many decades for therapy and diagnostics. In this ERC Advanced Grant, I will develop a radically new approach to control the activity of drugs, proteins and genes by biocompatible ultrasound. Polynucleic acid carriers, which can bind a wide variety of bioactive payloads, will be designed to be sensitive to different ultrasound sources, which can be applied in clinical settings and do not harm cells or tissues. Upon ultrasound irradiation, these carriers liberate their bioactive payloads by mechanochemical principles to switch on drugs and control cellular functions. To achieve this aim, I will: investigate the effect of ultrasound (US) on nucleic acid architectures; study the loading of polynucleic acids with different payloads and their release by US; develop a technology platform to activate small molecule drugs, proteins and oligonucleotides; and showcase the huge potential of these technologies for cancer immunotherapy, diabetes research and tissue engineering. This project will boost sonopharmacology and sonogenetics. Its outcomes will enable spatiotemporal control of drug action to minimize side effects in pharmacotherapy like cancer. The remote controlled orchestration of protein and gene function by US will strongly advance medicine and the life sciences by answering fundamental questions in these fields.

Keywords: stimulus responsive polymers mechanochemistry ultrasound nucleic acids drug carriers