Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Beyond WEIRD Witnesses: Eyewitness Memory in Cross-Cultural Contexts (WEIRD WITNESSES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-08-01
End date: 2024-07-31
Duration (months): 60.0
Total project cost (EUR): 1496770.0
EU funding (EUR): 1496770.0
Participants: 1
Project status: SIGNED

Our increasingly international society demands that eyewitnesses of serious crimes regularly provide testimony in cross-cultural settings, such as international criminal tribunals. This poses significant challenges for investigators and legal decision-makers. Errors in fact-finding may result in wrongful convictions and unjust acquittals. Yet, eyewitness memory research has predominantly focused on Western, Educated, Industrialized, Rich, and Democratic (WEIRD) witnesses. The project addresses two key objectives: (1) develop culturally modulated theory of eyewitness memory and (2) design and test evidence-based interview guidelines. In Subproject 1, I will examine what happens when police investigators interview eyewitnesses from a different cultural background. It will involve the systematic coding of culture-dependent variables in video-recorded police interviews with witnesses of serious crimes in South Africa, a society with many different subcultures. In Subproject 2, I will analyse the frequency, nature and legal consequences of culture-dependent variables in international criminal cases. It will involve an empirical document analysis of eyewitness evidence provided at the International Criminal Tribunal for Rwanda, and interviews with international legal scholars and practitioners. In Subproject 3, I will assess how different cultural groups encode, store and retrieve memories, and how memory reports are evaluated in immigration contexts. It will involve a series of experiments in which the objective and perceived characteristics of statements provided by asylum seekers originating from Sub-Saharan Africa are compared to a matched Western control group. The project integrates analyses of video, document and experimental data to provide insight into culture-dependent variables in eyewitness memory. The new theory will enable researchers and practitioners to steer away from the present WEIRD bias in legal psychology.

Keywords: eyewitness memory,international criminal law,investigative interviewing,cross cultural psychology,asylum seekers
Integral Membrane Proteins – an Approach to Rank Target Stability (IMPARTS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-03-01
End date: 2016-08-31
Duration (months): 18.0
Total project cost (EUR): 145501.25
EU funding (EUR): 145501.0
Participants: 1
Project status: CLOSED

This Proof of Concept proposal is designed to develop and test a novel way of monitoring the effects of drug binding to membrane protein targets. The idea stems from the basic research proposed in my ERC grant IMPRESS to study and rationalise the release of membrane proteins from detergent micelles in the gas phase of the mass spectrometer. During this research we discovered a new family of detergents, which we could formulate, to retain folded protein structure in the gas phase. Having achieved this goal, we then actively unfolded these assemblies in the mass spectrometer and by monitoring their unfolding trajectories we realised that we could quantify the effects of small molecule binding on protein stability. Not only can we now rank ligands according to their ability to confer stability but we can also count the number of molecules bound to a particular membrane protein target. By distinguishing bound molecules, either lipids or drugs, we can then carry out competitive binding experiments by displacing small molecules with higher affinity ligands.

Keywords: mass spectrometry,membrane proteins,drug binding,ligand ranking,lipids
Enhancing Belmont Research Action to support EU policy making on climate change and health (ENBEL)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Coordination and support actions
Countries involved: Austria,Estonia,Ireland,South Africa,Italy,Belgium,Sweden,Sweden,Sweden,Norway,Finland,France,Netherlands,United Kingdom,Pakistan,Botswana
Call: Enhancing the Belmont Forum Collaborative Research Action on Climate, Environment and Health (H2020-LC-CLA-2020-1, 2020)
Start date: 2020-11-01
End date: 2024-01-31
Duration (months): 39.0
Total project cost (EUR): 2993207.5
EU funding (EUR): 2993207.5
Participants: 17
Project status: SIGNED

ENBEL will support EU policy making by bringing together leaders in climate change and health research. We do so by coordinating a network of major international health and climate research projects under the Belmont Forum’s Collaborative Research Action (CRA), Societal Challenge 1 and 5 of EU’s Horizon 2020, and other national and international funding schemes. The network will develop evidence syntheses and co-produce with stakeholders a series of tailor-made knowledge products. The project will engage with EU policy advisors to translate science into policies that help shape low-carbon economies and build climate resilience in member countries while supporting EU diplomacy and development strategies. The overall concept of ENBEL is a bottom-up approach to networking and cooperation across the often separate worlds of climate and health research communities. This can have major impacts on knowledge production and policies. ENBEL brings together a consortium whose work generates actionable knowledge on how climate change-health risks will develop under global warming, what are the social costs and effective, cost-efficient and equitable mitigation and adaptation strategies. ENBEL focuses on three major climate change related health hazards: environmental and occupational heat, air pollution (particularly from wildfires) and climate-sensitive infectious diseases, with specific attention given to high risk groups and populations within Europe, and in Africa/Asia-Pacific region. ENBEL will support a knowledge management platform of EU funded research on climate change and health is two ways: A) build and manage a web-based knowledge platform of health impact of climate change by using innovative tools such as video, photos, maps and infographics; B) connect to existing and recognised knowledge platforms.Through our partners in low-and middle-income countries (LMIC), ENBEL will support, strengthen and establish channels for collaboration and capacity-building in LMIC.

Keywords: climate change,health,network,heat stress,vulnerable groups,occupational,outdoor workers,air pollution,wildfires,infectious diseases,knowledge management platform,eu policy making,lmic
Festival of Science European Researchers´ Night 2020 in Slovakia (ERN 2020 SVK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Slovakia
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-05-01
End date: 2021-01-31
Duration (months): 9.0
Total project cost (EUR): 267066.25
EU funding (EUR): 224950.0
Participants: 4
Project status: CLOSED

The European Researchers´ Night (ERN) in Slovakia is the biggest science popularisation event taking place every year since 2007. It is a public event aiming to bring researchers closer to general public, showcase the diversity of science and its impact on citizens’ daily lives and stimulate interest in research careers, especially amongst young people. This annual festival of science brings together hundreds of researchers from across the country. Project will organise wide variety of activities - main online event, visits of scientists in schools, science kits, competitions, accompanying and teasing events. The aim is to attract the general public, particularly people who are generally not interested in science

Keywords: science,research,innovation,communication,science policy
Triboelectrification-muscle dynamics framework for developing triboelectric nanogenerators (TENG) as implantable bio-applications (TEMD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: SIGNED

With explosive development and demand of implantable bio-applications, battery replacement becomes a key issue to achieve permanent implantation in vivo. Recent advances in energy nanogenerators have allowed for self-power function by conversing mechanical energy to electric energy, promising the battery-free implantation of bio-applications. Among the emerging nano harvesting technologies, triboelectrification initially proposed in 2012 is the front one due to universal availability, from enormous to tiny movements and even low-frequency motion in vivo. Another advantage of triboelectrification is the abundant choices of materials to meet the requirement of biocompatibility. Hence, the triboelectrification is the enabling technology for the next generation self-powered implant. Recently, researchers have commenced implanting triboelectric nanogenerators (TENG) in animals to evaluate the potential of energy harvesting from heart beating and respiration. However, the understanding of interactions between triboelectrification and muscle dynamics for energy harvesting is unclear. The experiments are limited in measuring, explaining and quantifying the performance of TENG by ignoring the complex dynamics of muscles, significantly hindering the application of TENG as implantable device. The proposal aims to develop a triboelectrification-muscle dynamics (TEMD) framework based on experiment and modelling to support the design, characterization and optimization of TENG for implantable bio-applications under different muscle dynamics on macro/nano scales. The framework will be able to (1) predict the output performance of TENG at any position of specific muscle, and (2) to design and optimize TENG in certain circumstances for the improvement of performance and durability. Such framework will also provide solid foundations and physical-mechanical guidance for other implantable energy harvesters, such as piezoelectric and flexoelectric nanogenerators.

Keywords: triboelectrification,muscle dynamics,triboelectric nanogenerators
A big jump in preventing problems in refractive surgery for myopia (KERASTOP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Spain
Call: Dedicated support to biotechnology SMEs closing the gap from lab to market (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-08-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The treatment of myopia using the excimer laser technology has been standardized globally. It is the main business for ophthalmologists in private practice. Most of patients undergoing laser refractive surgery achieve a good outcome, but there is a reduced volume of patients that develop a devastating disease, the post-LASIK ectasia. This condition is due to the performance of surgery in eyes with a pathology called keratoconus. It is not completely understood and generates a degradation of vision, with the potential of leading to extreme conditions requiring corneal transplantation. It is a very traumatic situation for both patients and doctors. Nowadays, keratoconus is only diagnosed when clinical signs are present. Ophthalmologists search for signs in the corneal surface indicating the potential presence of keratoconus and preventing the risk for the development of the disease. This leads to the avoidance of performing surgery in a great volume of patients due to a theoretical risk of ectasia development. CORNEA PROJECT has two biomarkers directly related to the presence of keratoconus. Based on the use of these biomarkers, KERASTOP will provide a fast in situ diagnostic test, with high levels of sensitivity and specificity (over 90%) that will facilitate the doctor to determine if the pathology is present, even in very initial stages not detected with the current diagnostic tests. KERASTOP will reduce the risks in refractive surgery, will increase the volume of candidates suitable for surgery and will allow the performance of more surgeries with more safety. CORNEA PROJECT is composed of two foundational partners with more than 15 years of experience in the laser refractive surgery sector worldwide. Likewise, the company has a human team composed of very relevant experts in the area of biotechnology and ophthalmology. In 5 years, the company is expected to have a positive EBITDA of more than 30 million of euros and to have generated more than 90 employments.

Keywords: keratoconus myopia astigmatism lasik ectasia
The first smartphone-connected medical device for a secure remote diagnosis of ears, nose, eyes and skin conditions (Cupris)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The Euro Health Consumer Index (EHCI) 2016 study on healthcare systems in 35 European countries has shown that gatekeeping to access specialists means increased waiting time and therefore high resource consumption, such as administrative personnel and infrastructure costs. Waiting times for specialist care are found predominately in systems requiring referral from primary care or general practice. Services such as otolaryngology, ophthalmology, dermatology may routinely be done from a patient’s location or from primary care sites to specialists to avoid waiting times and final diagnosis. Although telemedicine is an extremely attractive solution to bring healthcare closer to the patient, most of the current telemedicine technologies focus only on providing video or text communication tools. This misses a significant part of the consultation: the clinical examination and the taking of the patient history. We at Cupris Ltd have found a unique solution to enable the remote diagnosis for hearing, ophtalmology and dermatology diseases, the management of patient conditions and the taking of patient history. CUPRIS consists of a secure communication system (app and web-platform) for healthcare consultations that enables remote clinical assessment (including examination) of patients from any location with the help of smartphone-connected medical devices. Cupris smartphone-connected devices provide enhanced functionality and security over those currently used for a much lower cost (from 60% - 550% more price competitive). Among its advantages, it will help health systems to reduce waiting lists (up to 27% of the consultations) and associated costs; and it will help the patient to receive diagnosis in a shorter timeframe (even near to real time), without being physically present with specialists. Furthermore, thanks to its artificial intelligence algorithms, it will be the only solution in the market able to perform auto-diagnosis through a smartphone-connected medical device

Keywords: opthalmology,telemedicine,smartphone connected medical device,remote diagnostic
The EU as a leading global actor in Business and Human Rights: Towards a coherent policy framework (BHR_EU)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-16
End date: 2021-09-15
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

The European Union (EU) is a leading global actor in the domain of Business and Human Rights (BHR) given the importance of its market and the advanced regulatory efforts it has put in place in relevant domains. Human rights and sustainable development are core EU values and lay at the basis of its Common Commercial Policy (CCP). While being one of the major and most active voices in the BHR debate of the last decades, the EU does not currently have in place a comprehensive BHR policy framework capable of ensuring coherence between it CSR policies and its trade and investment policies. At the same time, in the EU approach to BHR, a tension persists between a voluntaristic model of Corporate Social Responsibility (CSR) and the adoption of hard-law solutions capable of inducing change in business practices and of improving access to effective remedies in Europe for victims of business-related human rights abuses. At present, the announced EU Action Plan on Responsible Business Conduct has not been adopted, yet, while there are growing calls on the EU from civil society, Member States and representatives of national Parliaments to adopt binding legislation in several BHR-related policy areas. As the EU is one of the main supporters of a meaningful implementation of the UN Guiding Principles on BHR, and has taken a critical stance on the possible adoption of an international binding treaty in this domain, it has a strong interest in ensuring the coherence and credibility of its approach to BHR. It is against this background that this research proposal, ‘The EU as a leading global actor in Business and Human Rights: Towards a coherent policy framework’ (BHR_EU) aims at analyzing EU’s growing role in BHR while highlighting areas of policy incoherence and inconsistency and proposing ways to elaborate and devise an effective EU policy framework on BHR. The proposed research adopts an interdisciplinary approach combining several branches of law and political sciences.

Keywords: business and human rights,corporate social responsibility,trade policies,investment policies
DETERMINING THE FUNCTIONAL CONSEQUENCES OF TRANSCRIPTIONAL ENHANCER ACTIVATION ON ALTERNATIVE SPLICING DURING EMT (ESEMT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Alternative splicing (AS) is a highly regulated process that is essential for creating the protein diversity required for correct cell-type specification. Misregulation of AS programs can lead to cellular dysfunction, developmental problems and disease, such as cancer. Understanding how alternative splicing is regulated during development and disease is therefore capital. Recent advances in the field have shown that, not only does AS regulation rely on the recruitment of various splicing factors to the pre-mRNA, but other phenomena such as RNA Polymerase II elongation rate, histone post-translational modifications or long non-coding RNAs have been shown to regulate this process. I hypothesize that transcriptional enhancers also play a critical role in the establishment and maintenance of cell-type-specific AS programs. I propose to study the effect of enhancer activation on AS regulation during the epithelial-to-mesenchymal transition (EMT), an important physiological process involved in tumour metastasis and cancer recurrence. Using genome-wide studies, I will map and physically link activated enhancers to intragenic regions of alternatively spliced genes over the course of the EMT in human mammary epithelial cells. I will then employ a candidate-based approach to tease apart the multiple processes through which enhancer activation can regulate splicing patterns, and to discover new enhancer-linked regulators implicated in the AS process. Long-term, this project aims to establish a direct functional link between enhancer activation and alternative splicing during development, with the ultimate ambition of being able to modify AS patterns through the regulation of enhancers. This study will yield results expected to have important implications for the understanding of how cancer-specific splicing programs are established and maintained and have the potential to discover innovative targets to revert EMT and in this way reduce tumour metastasis and cancer progression.

Keywords: enhancer,alternative splicing,cancer,3d interactions,epigenetics