Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advancing The Clinical Development Of Placental Malaria Vaccines In The Context Of Capacity Building and Use Of Digital Health Technologies (ADVANCE-VAC4PM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: France,Denmark,Netherlands,Burkina Faso,Germany,Malawi,Ghana,Benin
Call: Innovative approaches to enhance poverty-related diseases research in sub-Saharan Africa (HORIZON-HLTH-2021-DISEASE-04, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 9999995.0
EU funding (EUR): 9999995.0
Participants: 11
Project status: SIGNED

Placental malaria (PM) is a severe disease that affects a particularly vulnerable demographic group, pregnant women. The burden of disease is high, threatening more than 100 million women every year and causing the death of an estimated 50,000 pregnant women and up to 200,000 infants. An effective vaccine would be an attractive tool to control PM on its own, or to complement the existing yet imperfect tools. ADVANCE-VAC4PM will build on the success of previously conducted first-in-human (phase I) clinical studies in Europe and Africa, assessing the two PM vaccine candidates PAMVAC and PRIMVAC. The clinical trial results demonstrated that both adjuvanted vaccine candidates are safe and well-tolerated and induce good homologous immune responses demonstrating the feasibility of developing a PM vaccine. However, prior to embarking on costly, large scale phase II clinical trials, it is essential to optimize the cross-reactivity of the vaccines. Overall project objective is to advance the PM vaccine development and to broaden the immune response by i) increasing the vaccine-induced antibody level by using Virus-Like particles (VLP) to display the PM antigens or ii) by evaluating if a co-administration approach using PRIMVAC and PAMVAC-cVLP will increase cross-reactivity and cross-inhibitory antibody titers. These activities will be embedded in capacity building activities e.g. workshops, training of MSc/PhD students, small competitive research grants to African early career researchers and development of immunology laboratory capacity. In preparation of future PM vaccine trials, digital tools will be evaluated. Pregnancy registers will be developed and the feasibility and acceptability of using mobile applications for tracking pregnancy outcomes will be assessed. Modelling the cost-effectiveness, feasibility and acceptability of PM vaccines will further strengthen the case. Awareness on the need for a PM vaccine will be raised in stakeholder engagement activities.

Keywords: placental malaria,vaccine,capacity building,mobile applications,modeling,stakeholder engagement
Hybrid Knowledge Society (HYB-KNOW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-15
End date: 2025-09-14
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

Hybrid Knowledge Society (HYB-KNOW) is a two-year postdoctoral project situated at the intersection of philosophy, history, and cultural studies. The project’s overarching purpose is to overhaul the concept of the knowledge society in light of pressing contemporary concerns, such as the existential risks associated with the Anthropocene and the hybrid demands of the 21st-century knowledge ecosystem. The knowledge society was supposed to have initiated a technology-driven, science-based, and expert-governed way of life, but recent developments indicate that massive technology corporations exert significant influence over the public sphere, scientific institutions are challenged by resurgent extremisms, and expert knowledge is devalued in favor of conspiracy discourse. Moreover, researchers have shown that anthropogenic activity has a significantly negative impact on the Earth system, with potentially devastating consequences for long-term human survival. In these highly complex circumstances, the development of effective solutions will largely depend on the integration of the diverse, multiple elements that comprise the global knowledge ecosystem. Therefore, by drawing on the methodology of political-historical epistemology to design an innovative research framework that combines conceptual research with historical case studies, I will construct the concept of the hybrid knowledge society geared to integrate a wide range of disciplines and actors while avoiding the twin risks of neopositivism and postmodern relativism. The HYB-KNOW project will open up new research avenues, address multiple existing research gaps, and generate change-oriented knowledge to facilitate inclusive knowledge-making practices. In addition, HYB-KNOW will provide me with an opportunity to boost my research profile, improve my scientific training, and consolidate my integration in international academic networks.

Keywords: knowledge society,anthropocene,knowledge ecosystem,political historical epistemology,conceptual research,historical case studies,hybrid knowledge making
New late-stage functionalization reagents for the construction of chiral centers to impact drug discoveryhis her (NAKED-C)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: SIGNED

Late-stage functionalization (LSF) is a rapidly expanding field in molecular synthesis with the major goal of quickly accessing to derivatives that would be too challenging or time-consuming to prepare otherwise; hence, this strategy has a great potential to impact drug discovery processes by speeding up the hit-to-lead optimization. At present, more than two-thirds of prescription drugs contain at least one chiral center. However, the late-stage introduction of this structural motif using aromatic C–H bonds is an enduring challenge in synthesis. The goal of the NAKED-C project is to develop a new methodology for the construction of chiral centers in drug molecules, relying on the design and synthesis of a novel class of atomic carbon precursors that, upon successive and appropriate activations, would allow to build tailored asymmetric carbons. To achieve this goal, a new visible-light photoredox catalytic diazomethylation of aromatic C–H bonds will be developed. The collaboration with an industrial partner (secondment at AiCuris) will allow the application of this novel strategy to drug discovery in the search of effective antibiotics, thus merging multidisciplinary aspects with intersectoral knowledge transfer. The result will be a brand-new ‘assembly point’ for the construction of chiral centers in bioactive compounds, with the potential to become a late-stage diversity-generating synthetic platform for drug discovery programs. The proposal merges the host expertise in novel C−H functionalization strategies based on photocatalysis, and the researcher’s background in classical radical chemistry, metal-mediated synthesis and pharmacology, ensuring the two-way transfer of knowledge between the fellow and the host group. Successful development of NAKED-C will enhance the scientific and transferable skills of the researcher, while forthcoming to the fellow’s professional goal of pursuing an independent research career in academia in synthetic organic chemistry.

Keywords: photoredox catalysis,radical species,late stage c h functionalization
Bio-based fire-retardant thermoplastic composites reinforced with natural fibres. (THERMOFIRE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Research and Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Spain,France,Italy,Greece
Call: High performance bio-based polymers for market applications with stringent requirements (HORIZON-JU-CBE-2022, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 4473777.5
EU funding (EUR): 4473777.0
Participants: 12
Project status: SIGNED

One of the specific impacts of CBE JU programme is to replace at least 30% of fossil-based raw materials with bio-based and biodegradable ones by 2030, potential scope for bioplastics manufacturing processes is foreseen in the coming decade. The urgent need of increasing sustainability has also affected flame retardants. During the last decades, the number of studies based on developing bio-based flame retardants has increased considerably together with their incorporation in formulations based on bio-based polymers. However, the use of bio-based flame retardants with bio-based polymers has not been properly covered. The THERMOFIRE project aims to be a pioneer in this field, consequently, the flame retardancy of the 100% bio-based composites will be deeply developed and investigated. Fire retardancy is a key property of materials used for applications in the automotive, aerospace and textile sectors due to the need to minimize fire risk and meet safety requirements. In the THERMOFIRE project up to 100% bio-based polymers will be reinforced with different natural fibers (e.g., regenerated cellulose from wood and commercial flax) and bio-based flame retardants aiming at giving excellent flame retardancy to the final bio-based thermoplastic (TP) composites. The innovation of THERMOFIRE relies on the development of high-performance composites with a 20% reduction in weight and 15% in cost while maintaining the required levels of safety suitable for applications under stringent operating conditions. THERMOFIRE project represents a genuine opportunity to remove Europe’s dependence on imports of fossil-based polymers for stringent operating conditions in the aerospace, automotive and textile sectors.

Keywords: biodegradable,thermoplastics,sustainability,flame retardant
Structural Uncertainty-oriented REgularization Framework (SURE) for Inverse Design of Engineering Applications (IDEAs) (SURE IDEAs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-07-01
End date: 2028-06-30
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

This project will develop novel uncertainty-oriented regularization methods for inverse multi-task envelope designs of aerospace structures in the presence of uncertainty and subjected to multi-type loadings to meet strict space environment. An intelligent inverse design concept of a non-probabilistic regularization-based mathematical and computational (RBMC) framework will be proposed and developed for integrated load-structure design (ILSD). This framework can be defined as: Structural Uncertainty-oriented REgularization Framework (SURE) for Inverse Design of Engineering Applications (IDEAs). The applicant will create new knowledge and develop internationally recognized technology in cooperation with the team at the University of Southampton (UoS), UK. The main original contributions of this project are: (a) An adaptive uncertainty-based condensation model will be established for accurately capturing the dynamic performances of the complete nominal structure while fully retaining the information of uncertainty of the original structure. (b) A systematic methodology of non-probabilistic regularization framework will be established for robust regularization parameter selection to tackle ill-posedness. (c) An efficient reliability-oriented force control and safety-oriented maintenance framework for ILSD will be established. Dr. Yang has a strong record of high-quality publications in leading journals. He will be supervised by Prof. Daniil Yurchenko. Dr. Yang will have access to abundant computing and experimental facilities provided by UoS. His professional development will be underpinned by targeted training activities. The exploitation and dissemination will be planned and main contributions lie in the innovative technological development and breakthrough in ILSD. The tasks of this project are set up based on available resources to deliver the defined WPs.

Keywords: inverse dynamic analysis ill posedness uncertainty oriented regularization reliability oriented control safety oriented maintenance
Embodying Glocal Feminism: A New Cultural Movement in Catalonia (2017-2023) (GlocalFem)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: SIGNED

The fourth wave of feminism propelled by global trends and catalyzed by the #metoo movement in the early 2010s has ushered in new dimensions of online activism, mass media representation, and intersectionality. Scholarship has often highlighted the transnational nature of the feminist movement. However, this project aims to explore how 4th wave global feminism intersects with regional nuances, with a focus on the specific case of Catalonia. “Embodying Glocal Feminism: A New Feminist Cultural Movement in Catalonia (2017-2023)” (GlocalFem) examines the intersection of cyberfeminism and globalization with local factors such as the historically minoritized Catalan language, the stateless national Catalan identity, and feminist authors of the Catalan-Moroccan diaspora, as well as material urban changes in the city of Barcelona. The study emphasizes the necessity of an interdisciplinary model of analysis and proposes a new lens, "glocal feminism," to examine how the global 4th wave feminist movement translates locally. By utilizing an interdisciplinary methodology, GlocalFem examines a cultural and artistic movement that started in 2017 among millennial and Gen Z female cultural creators. These women navigate and challenge conventional boundaries through their knowledge production, blurring the line between popular/academic knowledge production, online/offline activism, and global feminist identity/Catalan national identity. Through the documentation and analysis of podcasts, TV series, films, social media accounts, and new spaces in the city of Barcelona, together with interviews with feminist content creators, this project seeks to understand how this new wave is shaping local realities in Catalonia. The study's findings could pave the way for similar investigations in peripheral regions of Europe, propelling feminist discourse within local contexts and minority languages and reconfiguring the landscape of knowledge production.

Keywords: cultural studies,catalan studies,4th wave feminism,cultural movements,popular culture
New implicit-surface Finite Element Methods to discover universal mechanisms of animal embryo development (FEM4Embryo)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: CLOSED

All living organisms emerge from a single cell, the zygote. In early embryo development of animals, the interplay of cell surface dynamics, polarity proteins and intracellular flows forms distinct polarity domains, which the cell uses to specify the fate of its daughter cells. A classical biological model to learn how animal cells polarise is the 1-mm long C. elegans roundworm. Establishment of cell polarity in the C. elegans zygote is well studied, yet the biophysical mechanisms controlling cell polarity beyond that stage remain largely unexplored. Biophysical experiments and Finite Element (FE) models could together elucidate this matter. However, FE models of multicellular morphogenesis, other than rare, rely on explicit surface descriptions. Explicit methods are not ideal to simulate cell polarity at the multicellular scale, because they can hardly deal simultaneously with 3D foamlike geometries, coupled surface-bulk physics and topology changes. Conversely, FE methods based on implicit surfaces have recently shown convincing potential to bypass this weakness. In this project, I will launch a new implicit-surface FE paradigm to simulate early embryo development and I will apply it to gain new insights on the patterning of C. elegans embryos. To this end, I will pioneer implicit-surface FE methods for coupled surface-bulk dynamics in foamlike geometries. The success of the project is ensured by joining leading expertise in implicit-surface FEs from myself, biophysics of morphogenesis from my supervisor, and patterning in C. elegans embryos from my external collaborator. I will be based at the Center for Interdisciplinary Research in Biology of the CNRS, located at Collège de France; a unique and ideal place to create new synergies between a FE researcher like me, biophysicists and cell biologists, as well as to grow and diversify my scientific and transferrable skills to become one of the few independent leaders in FEs for multicellular morphogenesis in Europe.

Keywords: finite element immersed boundary unfitted embedded multicellular simulations surface bulk flow couplings c elegans morphogenesis cell polarity polarity proteins mechanobiology actin cortex
dynamicC cOllaboration to geNeralize eCo-friEndly tRajecTOries (CONCERTO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: France,Italy,Germany,Iceland,Denmark,Sweden,Norway,Estonia,Latvia,United Kingdom,Netherlands,Belgium,Finland,Ireland
Call: Industrial Research & Validation for Aviation Green Deal (HORIZON-SESAR-2022-DES-IR-01, 2022)
Start date: 2023-07-01
End date: 2026-06-30
Duration (months): 36.0
Total project cost (EUR): 9039267.5
EU funding (EUR): 5054856.64
Participants: 24
Project status: SIGNED

CONCERTO aims to provide the means to maximize the opportunities for CO2 reduction and to introduce non-CO2 impact management in daily operations. The goal is to reach TRL6 processes and tools that allow the ecosystem to achieve more eco-friendly trajectories and thus higher climate impact reduction without requiring major changes on legacy ATM and airlines systems. To do so, two specific objectives are declined for CONCERTO. The first one focuses on CO2 emissions reduction when the second one introduces non-CO2 climate impact reduction mitigation means. Finally, as CONCERTO is a data driven project, generating data on CO2 and non-CO2 effects and opportunities at TMA, ATSU and possibly network level, the project presents the opportunity to contribute to the improvement of european environmental performances dashboards. Ambition #1- Keep the pace on CO2 emissions reduction, integrate Green ATC capacity in ATM processes, with the appropriate level of automation, and support ATM actors in balancing permanently regularity and environmental performance at local and network level. Ambition #2- By leveraging state-of-the-art climate science, allow ATM actors to take their “eco-responsibility” to the next level Ambition #3- Strengthen cooperation, anticipation and exchange of information between NM, Air Traffic Control, Airlines and Flight Planning Service providers. Ambition #4- Demonstrate that mitigation measures such as the eco-friendly orchestrator and ECHO area avoidance concepts can be deployed progressively at network level, in close connection with scientific progress

Keywords: green atc capacity,co2 and non co2 trade off,cooperation,eco friendly trajectories,traffic flow optimisation
Decarbonized liMe PrOduction through enhanced JoInt dielectric heaTing and waste carbonaceous material additiOn (MOJITO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Italy,Germany
Call: Towards cement and concrete as a carbon sink (HORIZON-EIC-2024-PATHFINDERCHALLENGES-01, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 2235763.33
EU funding (EUR): 2235763.33
Participants: 2
Project status: SIGNED

The MOJITO project aims to validate a laboratory scale system for the production of decarbonised lime with reduced energy consumption and carbon emissions in the calcination process, while achieving CO2 removal. The system is based on an electrically powered rotary kiln that transfers heat in the calcining material by microwave and electrical heating. Due to the capacity of microwaves to penetrate inside the limestone particles, the kiln will use lower temperatures with respect to standard systems. The input material will also be integrated with carbonaceous material for its ability to absorb electromagnetic energy and convert it to heat, thus improving the efficiency of the process. The CO2 produced by the calcination will be collected in an external vessel for further use in Carbon Capture and Storage (and Utilisation). Accurate atomistic computer simulations of the CaCO3 calcination process in realistic conditions through machine learning will be performed using a Tier-0 supercomputer, based on the understanding of the microscopic mechanisms at play. This will allow to study and design new solutions and the specific MOJITO systems. This enables the production of grade lime that satisfies up to 70% of market demand.

Keywords: lime,microwaves,calcination,machine learning,molecular dynamics,absorption spectra,carbonaceous materials,renewable electricity