Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Elliptic Combinatorics: Solving famous models from combinatorics, probability and statistical mechanics, via a transversal approach of special functions (COMBINEPIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2024-01-31
Duration (months): 72.0
Total project cost (EUR): 1242400.0
EU funding (EUR): 1242400.0
Participants: 1
Project status: SIGNED

I am willing to solve several well-known models from combinatorics, probability theory and statistical mechanics: the Ising model on isoradial graphs, dimer models, spanning forests, random walks in cones, occupation time problems. Although completely unrelated a priori, these models have the common feature of being presumed “exactly solvable” models, for which surprising and spectacular formulas should exist for quantities of interest. This is captured by the title “Elliptic Combinatorics”, the wording elliptic referring to the use of special functions, in a broad sense: algebraic/differentially finite (or holonomic)/diagonals/(hyper)elliptic/ hypergeometric/etc. Besides the exciting nature of the models which we aim at solving, one main strength of our project lies in the variety of modern methods and fields that we cover: combinatorics, probability, algebra (representation theory), computer algebra, algebraic geometry, with a spectrum going from applied to pure mathematics. We propose in addition two major applications, in finance (Markovian order books) and in population biology (evolution of multitype populations). We plan to work in close collaborations with researchers from these fields, to eventually apply our results (study of extinction probabilities for self-incompatible flower populations, for instance).
mRNA cap regulation and function in CD8 T cells (TCAPS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: United Kingdom,United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-05-01
End date: 2024-04-30
Duration (months): 72.0
Total project cost (EUR): 1991387.0
EU funding (EUR): 1066319.29
Participants: 2
Project status: SIGNED

CD8 T cells are vital for our response to infection, directly killing infected cells and stimulating other cells of the immune system. Major health problems world-wide involve deregulated T cells, including lymphomas, leukaemias, auto-immune disorders and organ transplant rejection. Damaging deficiencies of T cells are found in old-age. T cell development and response to pathogens is driven by regulated transcription and translation, however the mechanisms orchestrating this gene regulation are largely unknown, and are likely provide novel opportunities for therapeutic intervention. Our preliminary data reveals that a potent structure in gene expression, the mRNA cap, which co-ordinates RNA processing and translation initiation, is crucial for the development and activation of CD8 T cells. Regulation of mRNA cap formation is a novel concept in gene regulation in T cells, and also has not been studied in vivo previously. Our findings suggest the existence of an mRNA cap code, in which the different mRNA cap methylations regulate different genes and cellular functions. In TCAPS we will reveal how the mRNA cap code orchestrates CD8 T function. We will determine how the mRNA cap structures are regulated during CD8 T cell differentiation using the latest mass spectrometry technologies. We will determine the role of each mRNA cap methyltransferase in CD8 T cell gene expression during differentiation, using conditional knock-out mice in conjunction with enzyme biochemistry, RNA sequencing and quantitative mass spectrometry. We will determine the biological function of the mRNA cap methyltransferases in CD8 T cell survival and activation using immunological assays. TCAPS will also provide the first insight into the role of the mRNA cap code in vivo. The mRNA cap code is likely to be operational throughout mammalian physiology and therefore TCAPS will contribute significantly to our understanding of regulated gene expression in mammals.

Keywords: mrna,t cell
MAThematical modelling of Biofilm FOrmation on Biomaterials (MATBFOB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 337400.64
EU funding (EUR): 337400.64
Participants: 1
Project status: SIGNED

Biofilms play a pivotal role in healthcare-associated infections, especially those related to indwelling medical devices, such as intra-vascular and urinary catheters, cardiac pacemakers and orthopaedic implants. Many mathematical models have been developed to simulate and elucidate the main processes characterizing biofilm growth. Biofilm models have been widely acknowledged as a tool for fundamental understanding of wastewater treatment processes, the morphology of biofilm structures and for deciphering the manner in which they originate through the interaction of a couple of factors like: mass transfer, nutrient availability, detachment forces etc. However there has been very little or no endeavour to develop a suitable model for understanding the exact stages of microbial adhesion on biomaterials and the process of gradual establishment of microbial colonies on medical devices, considering the effect of substrate-microbe interactions . The proposed project consists of a brief and precise experimental part for investigating the initiation and progression of biofilm formation of Pseudomonas aeruginosa, a nosocomial pathogen, on implant surfaces through real-time monitoring. The experimental observations will be used to mathematically model the process of growth of biofilm on a biomaterial surface, considering the effect of interactions of microbes with a specific substrate and the rate of nutrient uptake.The project will employ currently used mathematical tools to model the spatio-temporal dynamics of biofilm formation of Pseudomonas aeruginosa on different biomaterial surfaces.The model will help in visualising the manner and the rate at which bacterial infections can spread on a particular surface and correlate it with the surface properties. This will be the initiation of - model guided substrate design of implants- a brand new concept for implant manufacturers, orthopaedic surgeons, biomaterial scientists, microbiologists and biofilm modellers.

Keywords: biofilms,implants,individual based modelling
Characterisation of the Plasmodium PHIST protein family (PfPHIST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

The malaria parasite is the ultimate home renovator, inducing drastic changes to the host red blood cell (RBC) important for virulence and sexual maturation. Members of the PHIST protein family are involved RBC modification and while some are expressed in the sexual stages, their function is unknown. To understand the significance of the extensive RBC alterations, the functional characterisation of the PHIST family is required. To begin this task, we have carefully selected 10 PHIST proteins to be analysed. First, we will set up novel techniques based on a microfluidics device that will greatly enhance our ability to study the rheological properties of the infected RBC. These new methods will improve our analysis of the infected RBC and also give unprecedented insights into the RBC modifications during the sexual stages, that to date have not been possible. We will also use cutting-edge molecular and biochemical analyses to ensure we get the highest level of data from such a broad and ambitious project. This embodies the first study to thoroughly investigate the role of RBC modifications in parasite virulence, and transmission of the sexual stages to mosquitoes. Dissecting the underlying mechanisms required to alter RBC will not only help to better understand how the disease develops but also how it’s transmitted, information vital to preventing this debilitating disease. This project will lay the foundation to characterise the entire PHIST family, and while this remains the long-term goal, having 75 family members puts this beyond the scope of this fellowship. In order to be able to characterise such a large protein family, a project such as this is required to carefully and precisely establish a pipeline for generating genetic mutants followed by accurate phenotypic analysis. The results obtained in this project will help to reveal the importance of parasite induced RBC structural and functional changes across multiple life cycle stages.

Keywords: malaria,membrane mechanics,protein export,virulence
Propelling Business Process Management by Research and Innovation Staff Exchange (RISE_BPM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria,Germany,Germany,Spain,Australia,Germany,Korea, Republic of,Netherlands,Netherlands,Brazil,Liechtenstein
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-05-01
End date: 2019-04-30
Duration (months): 48.0
Total project cost (EUR): 1273500.0
EU funding (EUR): 855000.0
Participants: 14
Project status: CLOSED

RISE_BPM networks world-leading research institutions and corporate innovators to develop new horizons for Business Process Management (BPM). BPM is a boundary-spanning discipline focused on division and re-integration of day-to-day work in organisations and on analysis of process data for organisational decision-making. Recent break-through innovations in Social Computing, Smart Devices, Real-Time Computing, and Big Data Technology create a strong impetus for propelling BPM into a pervasive corporate topic that enables design of entirely new products and services. All RISE_BPM consortium members possess excellent expertise in distinct aspects of the BPM lifecycle, ranging from Strategy and Modelling to Implementation and Analysis of business processes. RISE_BPM networks this complementary knowledge to create a unique environment for BPM research and innovation. The research activities are organised with reference to the design-science paradigm, including joint activities for analysing technological enablers and societal impact factors, as well as designing innovative IT artefacts for the BPM lifecycle. Staff secondments and joint events promote a cumulative exchange of knowledge in a think-pair-square-share approach that networks large-scale research capabilities and innovation projects carried out by the involved organisations. Key objectives of RISE_BPM are (a) to propel BPM research into the era of Social Computing, Smart Devices, Real-Time Computing, and Big Data Technology; (b) to enable companies to develop new products and services for designing and analysing business processes; and (c) to supply the involved staff with a unique intellectual environment for accumulating boundary-spanning knowledge and skills that refer to the entire BPM lifecycle. RISE_BPM extends the established administrative structures of the European Research Center for Information Systems (ERCIS) by involving additional BPM thought leaders and corporate innovators.

Keywords: business process management,bpm lifecycle,social media,smart devices,real time computing,big data,societal impact factors of technology
PRONTO: PROcess NeTwork Optimization for efficient and sustainable operation of Europe’s process industries taking machinery condition and process performance into account. (PRONTO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Spain,Germany,Germany,Germany,Spain,Italy,Norway,Poland,Norway,Norway,Poland,United States,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EID) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 3629764.44
EU funding (EUR): 3629764.44
Participants: 15
Project status: CLOSED

The typical lifetime of an industrial process plant is between 30 and 50 years. Technologies to enhance the operation and optimization of process plants can both guide the development of new state-of-the-art process plants and, perhaps more pertinently, can ensure that the large installed base of existing plants operates efficiently. The PRONTO Consortium partners are strongly convinced that for Europe to stay competitive, the overriding challenge is the efficient and sustainable operation of assets already installed and running at the present time. Production involves flows of material and energy over an extended area through the distributed and interconnected equipment of the process network. Process plants also generate complex information from disparate sources in the form of measurements from the process, mechanical and electrical sub-systems, and elsewhere. Efficient and sustainable operation of assets over a timescale of 30-50 years therefore requires sophisticated approaches for managing information and managing resources to ensure optimal operation. The research topics of PRONTO are (i) data analytics for assessment of the condition and performance of networks of equipment used for production in the process industries, (ii) optimization of use of resources in process networks taking account of real-time information about the condition and performance of the process equipment, and (iii) new concepts for process operation identified as having high potential for impact by industrial partners. The consortium partners include leading universities and well-known companies with high reputations for innovation. The consortium offers the early stage researchers training under the European Industrial Doctorate scheme by involving the non-academic sector extensively in joint supervision of the doctoral training with a strong emphasis on industrially-relevant PhD projects leading to practical demonstrations.

Keywords: bayesian statistics,data analytics,informatics,data fusion,machinery condition monitoring,prognostics,optimization,scheduling,process modelling,state estimation,mathematical program
Epigenetic Glioblastoma Therapeutics (EpiGlioT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-04-01
End date: 2018-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The goal of this project is to develop a successful treatment that combats the progression of glioblastoma and improve patients’ quality of life. Glioblastoma, the most malignant brain tumour, leads to disproportionately high morbidity in patients and impacts the economy through high mortality rates. The available treatment options are highly ineffective and pose a significant challenge to the healthcare budgets of all nations. Beactica aims to address this challenge by developing novel compound to inhibit the overexpressed in cancers protein LSD1. Beactica’s programme is based on a verified LSD1 knockdown technique and proves markedly more effective with glioblastoma clones that are resistant to other therapeutics. This way, Beactica’s compounds effectively clear cancer cells from which brain tumour might grow anew and will reduce the risk of relapses. This therapy will improve intervention outcomes for patients and lower additional treatment and healthcare costs including longer hospitalisation and further medical procedures. This programme is unique and there are no competitors using the same approach to treat glioblastoma by knockdown of the LSD1 protein with a small molecule. The ultimate success of this project will depend on the generation of clinical data which will improve opportunities for out-licensing. Beactica plans to apply for SME Phase 2 grant to take the lead compound through the clinical Phase I/IIa, and then reach the pharmaceutical market by an agreement with a strong licence partner. Beactica has an established business development contact network and has already gained trust of external investors in this innovative technology. The problem of cancer is growing dramatically and has been highlighted in the recent policy focus by the European Commission and the World Health Organisation. In this light, Beactica is assured of the significant impact the LSD1 knockdown innovation will have on the glioblastoma burden in Europe and worldwide.

Keywords: glioblastoma,lsd1,brain tumour
Spasers in the infrared range (SPIR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

One of the important directions of modern medicine is noninvasive diagnostics. The urgency of the problem is determined by the search of safe methods of examination and sparing techniques of collection of material for medical analysis when the patient does not feel pain, physical and emotional discomfort. Spaser (surface plasmon amplification by stimulated emission of radiation), also called nanolaser is a quantum generator providing unprecedented efficiency as a versatile tool in nanotechnology or biomedical research and applications. The spasers can generate in a single mode with a very high spectral density and intensity. This makes the spasers, arguably, the best multifunctional, super-contrast, low-toxic optical probes in biomedical research. For investigating spaser generation in a living organism it is imperative that their generation line should be located in the transparency window of biological tissues, namely in near infrared (IR) range of spectra. Hence, the main objectives of this project are development of an approach for the spasers synthesis (for IR range) in biocompatible aqueous solution as well as investigation of their the optical characteristics. A successful proof of concept will open the prospects of using spasers not only in medicine, but also for many other areas. Examples include the creation of high-precision sensors, fabrication of ultra-fast photonic nanocircuits, heavy-duty laser creation, etc. The multidisciplinary nature of the project is strong, involving a combination of inorganic, physical, colloidal chemistry, as well as optics and laser physics. This proposal includes both the transfer of knowledge to the host institution and the training of the candidate in new advanced techniques. Successful implementation of the project will make a significant contribution to the nano- and biotechnological industry of the European Union and improve European competitiveness.

Keywords: spaser,nanolaser,gold nanoparticles,nanoplasmonics
A systems biology approach to tackle PARP-inhibitors resistance and identify novel therapeutic targets to overcome it (PARPinhibit)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-12-31
End date: 2023-12-30
Duration (months): 36.0
Total project cost (EUR): 251002.56
EU funding (EUR): 251002.56
Participants: 2
Project status: SIGNED

Inhibition of PARP1 in cancer therapy is a recently adopted strategy to treat cancers where DNA repair is defective, such as breast and ovarian cancer caused by mutations in BRCA1 or BRCA2. In addition, PARP1 inhibitors (PARPi) can be useful even in the absence of BRCA mutations, likely due to pathogenic variants or epigenetic inactivation of other DNA repair related genes. However, development of resistance to PARPi is a significant challenge. To address this challenge, I propose to identify proteins that modulate PARP1 activity that could be used as additional therapeutic targets. The strength of this project is based on a systems biology overall strategy exploiting multiple independent datasets to identify candidates protein interactors, followed by a rigorous biochemical and genetic approach to characterize this interaction. Analysis of identified proteins and their role in PARPi resistance will be achieved at three main levels: a) in-silico and molecular studies of the interaction; b) influence on PARP1 activity and role in PARPi resistance after CRISPR-cas9 editing; c) expression levels in breast and ovarian cancer tissues. Results from this project will illuminate mechanisms of PARPi resistance and generate potential targets for therapy in breast and ovarian cancer. These results will contribute to the reduction in mortality due to breast and ovarian cancer and they will give an answer to this world-wide diffuse challenge.

Keywords: drug response and,or resistance,breast and ovarian cancer,parp1