Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Spatially-Separated Chirality Inspired Networks (SCHINES)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Switzerland,France
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 2313830.0
EU funding (EUR): 2313829.25
Participants: 3
Project status: SIGNED

Creating a brain-inspired technology through neuromorphic engineering could achieve or even surpass the extraordinary ability of the brain to grasp the world, which operates at an extremely low power consumption yet with the most complex interconnectivity known to mankind. The main goal of SCHINES is to set a clear direction to solve one of the biggest technological challenges that hinders this revolution: in existing physical neural network architectures, the desired interconnectivity can hardly be achieved. We will fabricate and design devices to demonstrate radically improved signal routing using topological metals. The design principle is simple: the environment of chiral electrons, electrons with spin locked to its momentum, can be engineered to create rich electronic lensing effect, analogous yet broader to light in-media propagation. Positive and negative effective indices of refraction for electrons, and lossless signal crossing can be engineered while maintaining, selecting or filtering the intrinsic topological protection of chirality, a degree of freedom that can be used for computation. These design principles are the basis for our device goal with scalable interconnectivity and are highly transferrable: they apply to strained materials, magnetic domains and heterostructures. This ambitious goal is realistic due to the interdisciplinary breadth of the SCHINES consortium: it is built out of established and emerging leaders called to shape the future of the field, joined in a public-private collaboration. They comprise an expertise that bridges the gap between the most abstract quantum field theory calculations with microscopic modelling with sample fabrication and measurement finalizing in device assembly

Keywords: electrical engineering,physics,charge transport,heat transport,quantum field theory,cmos,topological protection,chirality,interconnect,neuromorphic computing,magneto transport
The Logic of Conceivability: Modelling Rational Imagination with Non-Normal Modal Logics (LoC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands,United Kingdom
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 1996362.5
EU funding (EUR): 445362.0
Participants: 2
Project status: SIGNED

“The human imagination remains one of the last uncharted territories of the mind” - Ruth Byrne, The Rational Imagination Our mind represents non-actual scenarios to extract information from them. We cannot experience beforehand which situations are or will be actual. So we explore them in our imagination, leaving our perceptions offline: ‘What would happen if...?’. The cognitive importance of this activity is hardly overestimated. But what is its *logic*? The orthodox logical treatment of representational mental states comes from modal logic’s possible worlds semantics: the modal analysis of knowledge, belief, information, was taken up by philosophy, linguistics, and Artificial Intelligence. However, the approach faces major problems. By systematically addressing them, the Logic of Conceivability (LoC) project will yield a paradigm shift in our understanding of the logic of human imagination. One major purely logical problem is that mainstream epistemic logics model cognitive agents as logically omniscient, thus as disconnected from the reality of human, fallible minds. One major philosophical problem concerns the entailment from conceivability to so-called absolute possibility in ‘thought experiments’ of theoretical philosophy: how does conceiving a scenario give evidence of its possibility? LoC will address such issues via the techniques of non-classical logics with non-normal worlds semantics. It will make logically precise the distinction, taken from cognitive science, between Fast Thinking (associative, context-sensitive) and Slow Thinking (rule-based, analytic). It will show how omniscience is avoided, and evidence of absolute possibility is achieved, in different manners in the Fast and Slow Way. Based at the Institute for Logic, Language and Computation, and advised by a Board of researchers from Europe, the US, and Australia, LoC will deliver high-impact outputs in top journals, a book, and knowledge dissemination results for non-specialists.

Keywords: non classical logics,paraconsistent logic,worlds semantics,non normal worlds,epistemic logic,intentionality,knowledge and belief representation,cognition,cognitive information processing
Exploiting transmedia skills and informal learning strategies to improve formal education (TRANSLITERACY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Uruguay,Finland,Colombia,United Kingdom,Portugal
Call: Human-centric Digital Age (H2020-ICT-2014-1, 2014)
Start date: 2015-04-01
End date: 2018-03-31
Duration (months): 36.0
Total project cost (EUR): 1066492.5
EU funding (EUR): 1066489.0
Participants: 9
Project status: CLOSED

The aims of the TRANSLITERACY project are to understand how teenagers are learning outside the school and to introduce those experiences into it. The ethnographic identification and analysis of the (trans)media skills will be at the centre of the research program. Once identified the informal learning strategies applied by young people outside the formal institutions, the team will translate them into a series of proposals to be implemented into the schools. The TRANSLITERACY Project will involve an interdisciplinary group of 25 senior and junior researchers with sound experience in fields such as media literacy, transmedia storytelling, user-generated contents and participatory culture, ludology, traditional and virtual ethnography, pedagogy and innovation in education. The research will focus on the following set of skills: • Problem-solving strategies developed by teens in video gaming (Videogame literacy) • Content creation, production and sharing strategies developed by teens in fan fiction (Participatory culture literacy). • Content creation, production and sharing strategies developed by teens in social media (Web / social networks literacy). The research will focus on 12-18 years old teens, an age characterized by a short but intensive experience in the use of new media and digital technologies. The fieldwork –based on surveys, interviews, focus groups, participant observation, and online activities analysis- will be simultaneously developed in 9 countries: Australia, Colombia, Finland, Italy, Mexico, Portugal, Spain, United Kingdom, and Uruguay. The duration of the research will be 3 years. After mapping the transmedia practices and informal learning strategies the team will produce an open and customizable Teacher’s Kit based on the outputs of the research. The kit will propose learning strategies and activities to be developed with students into the schools.

Keywords: media literacy,transmedia literacy,transmedia storytelling,e skills,internet and transmedia skills,informal learning,teenagers,ethnography,videogames,social networks,participatory culture
Quick and cost-effective integrated web platform for forest inventories (WoodStock)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Spain
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-03-01
End date: 2017-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

WoodStock represents the future of how forest inventories will be realized allowing a rapid, efficient and eco-sustainable management of forest resources. So far, forest inventories have always relied on field work to achieve a precision sufficient to be used as a management tool. WoodStock will allow, through the use of a powerful and innovative algorithm and an online and automatic platform, making inventories just using electronic geographic data made available for the administrations of EU Member States. The months for the realization of forest inventories will become minutes, and the cost will be knocked down. Woodstock main customers will be a) all the woodworking industries requiring a quick and precise inventory for forest exploitation; b) private landowners requiring a cheap inventory to comply with local regulation and c) forest consultants that will use our inventory to define forest management strategies. A β-version of WoodStock platform has been already realized and validated in Spain through several data collection campaigns and data analysis which demonstrate the algorithm in relevant environment (TRL 7). The project will optimize the algorithm for different EU biotopes and the automatic data download from administrations' servers of targeted countries. Phase 1 will provide an assessment of the viability of our established technical objectives and will define the actions for its optimisation. Furthermore it will contain a market analysis and the best entry strategy to disseminate and exploit the results. WoodStock will not just boost AGRESTA business, making us a technical and commercial reference among forest consultants, but as well it will contribute to the growth of the whole EU forestry sector, improving its eco-sustainable management, mobilizing the market and creating new job positions.

Keywords: forest inventory,forest management,on line platform,biomass assessment,eco sustainability,electronic geographic data
Revitalizing the clinical potential of type I IFNs in fighting influenza A virus infections with AcTaferon. (AcTaferon)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2018-12-31
Duration (months): 20.0
Total project cost (EUR): 144230.0
EU funding (EUR): 144230.0
Participants: 1
Project status: CLOSED

Based on their antiviral and antitumor effect, type I interferons (IFNs) were believed to be the miracle drug to tackle viruses and cancer. However, clinical IFN applications remained limited due to severe side effects resulting from widespread cellular sensitivity to IFN, which limits the administrable doses. Hence, the drug concentration at the desired infection or tumor site is often too low to be fully therapeutic efficient. AcTaferon (Activated-by-Targeting interferon), co-developed by Prof. Uzé, circumvents these obstacles. By fusing an IFN mutant with strongly reduced receptor binding affinity to a targeting moiety that recognizes a surface marker on specific cells, AcTaferon remains inactive “en route” through the body and unveils its biological activity only on specific target cells. Robust tumor regression without side effects and preliminary antiviral effects underscore the huge clinical potential of AcTaferon to fight cancer and viral diseases. By combining the AcTaferon and influenza expertise of Prof. Uzé and Prof. Saelens, respectively, this interdisciplinary project offers the opportunity to broaden the innovative AcTaferon therapeutic strategy from the cancer to the viral infection field. Influenza A was selected as a pilot target as seasonal influenza A epidemics and occasional pandemics remain a serious health threat causing substantial morbidity and mortality. Influenza A-targeted AcTaferons will be developed and analyzed in relevant in vitro and in vivo models. Eventually, all knowledge will be transferred to Orionis, a company that will implement the AcTaferon technology to develop novel drugs. My background on the intracellular processes that negatively regulate cytokine receptors and hence influence the cellular sensitivity to a (therapeutic) cytokine is an asset to this project. I will be able to extend my fundamental research experience with applied cytokine research, which may extend into a new academic or industrial research pipeline.

Keywords: influenza a,new therapeutic strategy,cytokine based
Investigating susceptibility to trypanosomatid parasites using Drosophila melanogaster as a model (FlyTryp)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

One of the specific United Nations Sustainable Development goals is to end epidemics of neglected tropical diseases by year 2030. Some of the most devastating of these diseases are caused by trypanosomatid parasites that are transmitted to humans via the bites of infected insects from the order Diptera (Flies). While most natural fly vectors pose a challenge to study under laboratory conditions, Drosophila melanogaster, with its well-established molecular, genetic and genomic toolkit and a vast amount of prior knowledge of its biology, is a proven model for experimental studies. Because D. melanogaster is host to several natural parasites that belong to the trypanosomatid group, it can also serve as a model for studying fly-parasite interactions. In this project, we propose to take advantage of the Drosophila melanogaster Genetic Reference Panel (DGRP) to investigate the genetic basis of fly susceptibility to trypanosomatid infection. First, we will perform a genome-wide association study (GWAS) for natural susceptibility to trypanosomatid parasite using a well-developed DGRP mapping resource to map genetic variation in susceptibility. Further, we will also test for differences in gene expression associated with infection susceptibility, using RNA sequencing, and validate the candidate genes identified with GWAS and RNA sequencing. Together, along with the well-annotated Drosophila genome, these data will reveal functional pathways affecting susceptibility to trypanosomatid infection. The established Drosophila-trypanosomatid system can serve as a functional model for insect-vectored diseases in medically and economically relevant species of Diptera.

Keywords: drosophila,trypanosomatids,evolutionary genetics,host parasite interaction
Bismuth Compounds in Radical Reactions: Fundamental Aspects and Synthetic Applications (Bismuth Goes Radical)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany,Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 1470753.0
EU funding (EUR): 1357833.4
Participants: 2
Project status: SIGNED

The classical distinction between transition metal and main group compounds has recently been challenged. This is due to the extraordinary properties and reactivity of low-valent and radical main group species, which chemists have begun to unveil. The development of reliable synthetic approaches to new types of low-valent main group compounds and the thorough understanding of their bonding situation, (electronic) structure, and reactivity is one of the major challenges of modern main group chemistry. Bismuth (Bi), a non-precious, non-toxic, heavy p-block element, offers unique properties for the use in synthesis and catalysis. Its large and diffuse atomic orbitals (AOs) result in an inefficient overlap with AOs of other atoms, leading to low homolytic bond dissociation energies. Also, relativistic effects contribute to the stabilisation of Bi radical species. In combination, these effects allow for reversible homolytic bond dissociations of molecular Bi species. Due to the lack of effective strategies for the exploitation of these remarkable properties, Bi compounds remain underexplored. This ERC proposal is designed to tackle this challenge by creating innovative methods to explore novel Bi compounds in radical reactions and unlocking their tremendous potential in synthetic chemistry. It comprises three projects: P1) Bi complexes tailored to undergo (reversible) homolytic bond dissociations, P2) novel strategies for the generation of Bi(I) species with unique (singlet vs. triplet) electronic structures, and P3) geometrically constrained complexes with Bi−Bi bonds susceptible to tuneable homolysis. The compounds targeted in P1-P3 will be exploited in novel radical reactions aimed at element–element bond formation, CH activation, small-molecule activation, and catalysis for organic synthesis. The ERC project will benefit from the extensive experience gained by the applicant’s group in Bi chemistry. Preliminary results have been obtained for all three sub-projects.

Keywords: main group chemistry,radical chemistry,organometallic chemistry,bismuth chemistry,low valent compounds
MagnetoPrint: Sizing and Magnetically-assisted 3D Printing of Smart Metamaterial Hydrogels for Tissue Engineering (MagnetoPrint)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: SIGNED

3D printing (3DP) technology plays a pivotal role in the biofabrication of engineered tissues which are useful towards several clinical, diagnostic and research applications. Of the different 3DP approaches, extrusion bioprinting (EBp) is the most widely used, for it is cost effective and allows rapid fabrication of physiological scale tissues with controlled placement of different types of encapsulated cells and biomaterials. However, the poor resolution (> 200 µm) of most EBp approaches limits the topographical cues necessary to impart anisotropic cell (avg. ϕ = 20 µm) and extracellular matrix organization within the tissues. Moreover, most tissue engineering approaches do not meet the nutritional requirements of the cells within thick tissues, and utilize static cultures which do not recapitulate the physiological growth conditions. Due to these reasons, the engineered tissues fail to biomimic native tissue properties. The proposed MagnetoPrint process aims to achieve biomimicry via a synergy of chemistry, biology, electromechanical systems design, structural mechanics and multiphysics modeling. First, cell-laden hydrogels are synthesized which could be sized into microstrands (avg. ϕ = 40 µm) during printing, that could impart the relevant anisotropic characteristics. Second, ferromagnetic particles are incorporated within distinct compartments inside the hydrogels to facilitate the deformation of printed tissue in the presence of external magnetic fields. Control of the domain orientations of the magnetic particles is used to impart auxetic properties, to further support nutrient transport and tissue maturation, which is also verified by computational modeling. Third, a complex muscle/tendon interface is printed and matured under the relevant exercising conditions to demonstrate the effectiveness of the project. The process, with its unprecedented features, represents significant progress in the advanced scalable manufacturing of biomimetic engineered tissues.

Keywords: 3d printing,3d bioprinting,hydrogels,metamaterials,tissue engineering,auxetic structures,negative poisson s ratio,muscle,tendon,electromagnetics,finite element analysis,comsol multiphysics
Seeing hydrogen in matter (SHINE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-02-01
End date: 2023-01-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Observing hydrogen (H) in matter is a formidable challenge. Despite being ubiquitous in nature, it is elusive to scientific scrutiny like no other element. It is often portrayed as either a blessing or a curse. Certainly, it is a prime candidate for producing low-carbon emission power. But no less important is the effect of hydrogen embrittlement which has resulted in many catastrophic failures of engineering alloys. In aid of this, SHINE will realise multiple ambitions. It will facilitate the direct imaging and quantification of H atoms in candidate metallic alloys and metal-organic frameworks for gaseous storage, allow the discovery of new solid-state hydrides with controlled release, and help the improvement of fuel cell materials for energy generation. All these applications have relevance to a ‘low-carbon-emission economy’ that humanity must develop in the 21st century. SHINE will exploit a novel and entirely unique infrastructure, designed and currently implemented in the PI’s group. It will directly provide three-dimensional hydrogen mapping at the near-atomic scale. By connecting and relating this fundamental knowledge and observed physical properties, we will enable unprecedented precision in the prediction of material behaviour and so resolve to unlock control over the behaviour of hydrogen in such materials. Atom probe tomography will be the principal method of a correlative microscopy and spectroscopy approach to investigate materials where precise knowledge of the distribution of H is crucial. Informed by experimental data, modelling and simulations will provide a mechanistic understanding of the behaviour of H in materials. Novel hardware and data-treatment approaches will be developed to maximise data quality and provide new insights of the behaviour of H in the complex and dynamic microstructures of engineering materials, thereby allowing us to devise manufacturing strategies to enhance their performance and durability.

Keywords: hydrogen economy,hydrogen embrittlement,microscopy,atomistic simulations