Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Tracking memory during sleep: understanding how re-play of complex information affects memory and mental health (MemoryTracker)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1984125.0
EU funding (EUR): 1984125.0
Participants: 1
Project status: SIGNED

The field studying the processing of memory during sleep has been gaining attention lately, leading to some significant progress in our understanding. However, the challenge now is to translate these in-sights into practical psychotherapeutic options for mental disorders that are traditionally hard to treat. Our research aims to address this gap by using innovative behavioral paradigms and advanced neuro-scientific methods to tap into the therapeutic potential of sleep. Rather than treating clinical utility as an afterthought, we have integrated it into the core of our proposal (work package D). During sleep, memories undergo a replay process that strengthens and trans-forms them. We want to provide direct evidence of this phenomenon in humans, building on studies in rodents and humans. Our approach involves creating a reliable procedure to track memory reprocessing using a cutting-edge MEG scanner with machine learning to identify replay events during sleep. We'll also explore how complex memories unfold over several weeks and use a novel behavior-al paradigm to generalize how complex memories are consolidated. This will allow us to examine how depression can disrupt this process, offering new possibilities for therapy. While developing these methods presents challenges and the outcomes are uncertain, we believe the potential benefits make it worthwhile. Success in our project could pave the way for future efforts to manipulate memory replay during sleep—an exciting possibility. The project provides a vital step to later establishing a closed-loop approach that both measures and responds to replay, e.g., by acoustic or electrical stimulation techniques. We hope in the end to pioneer techniques that can support therapy for prevalent mental health challenges like depression, schizophrenia, and addiction—issues that are particularly pressing in the European Union.

Keywords: sleep,long term memory,replay,depression,consolidation
EIT Manufacturing Business Plan 2023-2025 (EITM BP 2023-2025)

Framework: Horizon Europe — Innovative Europe
Programme: The European Institute of Innovation and Technology (EIT)
Theme: EIT Manufacturing
Destination: EIT Manufacturing
Action type: Knowledge and Innovation Communities
Partnership: EIT Manufacturing (EIT KICs)
Countries involved: France,Germany,Austria,Sweden,Italy,Spain,Greece
Call: EIT Manufacturing Business Plan 2023-2025 (HORIZON-EIT-2023-2025-KIC, 2023)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 119780232.74
EU funding (EUR): 119780232.74
Participants: 8
Project status: TERMINATED

The main goal for the years to come is the transformation of EIT Manufacturing into a well-regarded service organisation offering qualified services to the European Manufacturing domain. This transformation will include all parts of the organisation; the pillars, the CLCs and the Manufacturing SASU. An extensive catalogue of possible service offerings has been established and prioritised. The first results have been achieved already. According to our go-to-market strategy, services will be piloted by the CLCs or the Manufacturing SASU and, if successful, rolled out over the whole organisation. The first portfolio of start-ups with financial sustainability agreements has been established, with an estimated valuation of more than €2 million. EIT Manufacturing will focus its investment in the next three years on the “European Manufacturing System”, taking an integrated European approach of all pillars: Innovation, Education, RIS, Business Creation and Communication. The “European Manufacturing System” will play a key role in the Circular Economy. It will link the steps of value creation processes in a multidimensional way, in order to identify the environmentally, economically and socially sustainable favourable alternatives for each step, going from an idea to a finished product, process or service. With Europe’s sensitivity for sustainability, and its ingenious talents in developing innovative technologies, processes and means of collaboration, Europeans are destined to lead the way to further evolved and improved Manufacturing Systems. EIT Manufacturing, in cooperation with its partners and ecosystem, helps drive this leadership by postulating the “European Manufacturing System” as a strategic objective for the European manufacturing industry, with global implications. The Business Plan implementation will fully comply with the EIT Financial Sustainability principles, KIC fund principles, Innovation Principles, EIT RIS Hub Minimum Standards and Good Governance principles.
HERITAGE ACTIVATION THROUGH ENGAGING EXPERIENCES TOWARDS SUSTAINABLE DEVELOPMENT (HERITACT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Greece,Ireland,Italy,Spain,Belgium
Call: The New European Bauhaus – shaping a greener and fairer way of life in creative and inclusive societies through Architecture, Design and Arts (HORIZON-CL2-2022-HERITAGE-01, 2022)
Start date: 2023-03-01
End date: 2026-02-28
Duration (months): 36.0
Total project cost (EUR): 2999388.5
EU funding (EUR): 2999388.5
Participants: 15
Project status: SIGNED

The future of Europe’s rich cultural heritage is facing several challenges due to various threats including climate change, natural or man-made disasters and lack of finance. Meanwhile, global processes have a deep impact on the values attributed by communities to urban areas and their settings. Despite Europe’s common values and creative diversity of traditions, crafts, arts and architecture, social discrimination, based on ethnicity, race, sex or gender and other characteristics persists in Europe, and is one of the key drivers of social exclusion. Access to cultural heritage experiences contributes to social cohesion and inclusion, by strengthening resilience and the sense of belonging and improving well-being. In this view, there is a need for new design solutions that are resilient to the changing conditions and sensitive to local cultural heritage, and to local topographic and climatic conditions. HERITACT will consider cultural transformations driving sustainability and will explore new cooperation paths among relevant stakeholders, interested in designing a new European way of life in line with the New European Bauhaus. To this end, HERITACT intends to empower communities’ co-creation capacity and to redefine the role of cultural heritage in urban regeneration. HERITACT will identify and enhance community-oriented processes and will introduce innovative and inclusive architectural and design solutions and cultural-artistic practices to support environmental and cultural sustainability, and to strengthen the cultural and creative industries through community awareness and policy making across European urban areas of many different scales and cultural settings. Interdisciplinary methodologies will provide stakeholders at 3 different cultural urban contexts across Europe a decision-support system based on collaborative approaches for the reactivation of unused cultural heritage spaces, and/or for enhancing diverse communities‘cultural identity and values.

Keywords: sustainability,well being,user experience,inclusion,placemaking,ar vr
Engineering Vascularized Implants for Personalised Osteochondral Tissue Regeneration: From medical imaging to pre-clinical validation (EngVIPO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal,Serbia,Germany,Poland,Spain,China
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 1366200.0
EU funding (EUR): 1311000.0
Participants: 8
Project status: SIGNED

Osteochondral Injuries (OCI) is a challenging yet common clinical problem for orthopaedic surgeons worldwide and is associated with multiple clinical scenarios ranging from trauma to osteonecrosis. Strategies for functional tissue regeneration at still far from the clinics and should endeavour to heal the subchondral bone and joint interface and hyaline cartilage. Enhancing the understanding of the mechanisms that underlie OCI holds the potential to unlock ground-breaking advancements in therapeutic interventions. EngVIPO tackles current challenges in the realm of biofabricated patient-specific implants with enhanced vascularity and functionality, concerning scientific expertise and collaborations with renowned institutions for OC tissue engineering, within the interdisciplinary domains of 3D computational modelling, advanced manufacturing, 3D in vitro models, and nanotechnology, and boosting clinical translation of the tissue engineered products. The project is focused on catapult knowledge exchange and create research synergies on the development of innovative biomaterials and bioinks, emerging technologies, biobanks and personalized medicine, for the complete regeneration and establishment of normal function of injured/diseased OC tissue. This will range from advanced biomaterials/scaffolds incorporating bioactive ions with osteogenic function, implementation of innovative manufacturing technologies, spheroids/organoids integrated into microfluidics, therapeutic biologicals and biobanks, in silico modelling, in vitro immunocompatiblity, to in vivo evaluation. Such innovative approach represents a significant advancement in the field of orthopedics, leading to improved participation of biobanks towards the development of advanced implants and patient outcomes, and setting new standards for personalized implant solutions.

Keywords: osteochondral scaffolds
Design of Immune Modulating Dendritic Networks for future treatment of Diabetic Foot Ulcers (HYPERNET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden,Switzerland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-10
End date: 2028-06-09
Duration (months): 36.0
Total project cost (EUR): 434048.88
EU funding (EUR): 434048.88
Participants: 2
Project status: SIGNED

Diabetic foot ulcers (DFU) are one of the most severe and costly long-term diabetic complications, causing a considerable financial burden to patients and healthcare sectors globally. Most commercial wound dressing materials are based on linear natural or synthetic polymers, and they are not capable of treating DFU efficiently. Innovative material design and therapeutic methodologies are critical to provide improved treatments for DFU. Hyperbranched dendritic polymers show advantages of having multiple terminal groups for multivalent interactions, low viscosity, cost-effectiveness and large-scale production in high yield, which are important features in practical biomedical applications. The aim of this proposal is to develop advanced cationic dendritic networks (CDNs) which are designed to eliminate infections and stimulate favorable immune modulation during the DFU healing process. In this context, a library of cationic heterofunctional hyperbranched dendritic-linear-dendritic copolymers (HBDLDs) based on polyethylene glycol (PEG) and 2,2-bismethylol propionic acid (bis-MPA) will be synthesized and hybridized with collagen to fabricate well-defined CDNs to deliver insulin locally for improving DFU treatment. The cations will provide long-term antibacterial activity; collagen, insulin and the dendritic structures and cationic charges are envisioned to provide the immune modulation during DFU healing process. I will study the effects of the CDNs on skin cells at molecular level, and identify functional groups and structures of materials that can actively promote DFU healing. Proof-of concept wound dressings will be designed based on the material properties and gelation mechanism, and methods for large scale production of the optimized hydrogels will be explored. It is promising that this project will provide a better treatment for DFU and potentially other chronic wounds.

Keywords: hyperbranched dendritic polymers antibacterial antibiotic resistance immune modulation anti inflammation hydrogels fibers electrospinning diabetic foot ulcers chronic wounds
Supramolecular microcapsules for bioreactor expansion of induced pluripotent stem cells (SUPROTECT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-06-01
End date: 2025-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The SUPROTECT proof-of-concept project seeks to apply our squaramide-based (SQ) supramolecular materials to prepare microcapsules for the culture of pluripotent stem cells. Building on earlier demonstration of bioactive hydrogel synthesis and in vitro culture of iPSCs in 3D cell culture under static conditions, we will synthesize the necessary amount of material for iPSC culture studies, develop protocols to prepare microcapsules with and without iPSCs, and evaluate the feasibility of the different microcapsules for the culture of iPSCs and their release, ranking the approaches on iPSC number and quality for further downstream application. In parallel with these activities, we will perform detailed market research studies on microfabricated polymer materials for culture of various cell types, protecting our intellectual property (IP) position and consolidating our findings in a package for product licensing with the appropriate party.
VIrtual GuardIan AngeLs for the post-truth Information Age (VIGILIA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Belgium
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2490000.0
EU funding (EUR): 2490000.0
Participants: 1
Project status: SIGNED

This project is motivated by the hypothesis that we are approaching a post-truth society, where it becomes practically impossible for anyone to distinguish fact from fiction in all but the most trivial questions. A main cause of this evolution is people’s innate dependence on cognitive heuristics to process information, which may lead to biases and poor decision making. These biases risk being amplified in a networked society, where people depend on others to form their opinions and judgments and to determine their actions. Contemporary generative Artificial Intelligence technologies may further exacerbate this risk, given their ability to fabricate and efficiently spread false but highly convincing information at an unprecedented scale. Combined with expected advances in virtual, augmented, mixed, and extended reality technologies, this may create an epistemic crisis with consequences that are hard to fully fathom: a post-truth era on steroids. In the VIGILIA project, we will investigate a possible mitigation strategy. We propose to develop automated techniques for detecting triggers of cognitive biases and heuristics in humans when facing information, as well as their effect at an interpersonal level (their effect on trust, reputation, and information propagation), and at a societal level (in terms of possible irrational behaviour and polarization). We aim to achieve this by leveraging techniques from AI itself, in particular Large Language Models, as well as by building on advanced user modelling approaches from the past ERC Consolidator Grant FORSIED. Our results will be integrated within tools that we refer to as VIrtual GuardIan AngeLs (VIGILs), aimed at news and social media consumers, journalists, scientific researchers, and political decision makers. Ethical questions arising will be identified and dealt with as first-class questions within the research project.

Keywords: post truth user modelling large language models mis,dis,and malinformation cognitive biases and heuristics
Waves for energy in magnetized plasmas (SMARTWAVES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Spain
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 3034433.75
EU funding (EUR): 2511038.0
Participants: 1
Project status: SIGNED

The interplay between energetic particles and magnetohydrodynamics (MHD) fluctuations plays a paramount role in a modern society with growing energy demands and active interaction with the space weather. The prediction of space weather and viability of fusion as a virtually unlimited source of energy rely on a good understanding of fundamental wave-particle interactions. Although the sources of energetic particles are quite different for space, astrophysical and laboratory plasmas, the main challenges remain the same: 3D multi-scale physics and non-linear wave-particle interactions. In the framework of SMARTWAVES, a potentially revolutionary plasma regime for future burning fusion plasma devices with tailored MHD activity will be developed. Novel diagnostic techniques to monitor the temporal evolution of the energetic ion distribution in phase-space will allow the identification of the fundamental wave-particle resonances responsible for the experimental observations. Combined with the next generation of electron fluctuations diagnostics, I will provide a complete physics basis of currently inaccessible wave phenomena. This will pave the way towards a high-confinement plasma regime that closes the burning plasma performance and exhaust gap, simultaneously maximizing the fusion gain and minimizing the plasma-wall interaction. Advanced 3D non-linear codes validated in tokamak plasmas will be applied to relevant solar events paving the way to a space weather forecast station. I will apply the basic knowledge gained in tokamaks with advanced in-situ diagnostics to test and further develop hybrid models and numerical tools shared by the fusion, space and astrophysical communities. This project will represent a gateway between the space, astrophysical and fusion communities opening new horizons for a common ground science.

Keywords: plasma physics,magnetized plasmas,magnetic confinement,wave particle interactions,particle transport and acceleration,magnetohydrodynamics,solar physics
Inexhaustible Spring of Hyperpolarization For Magnetic Resonance (HypFlow)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2990000.0
EU funding (EUR): 2990000.0
Participants: 2
Project status: SIGNED

Nuclear magnetic resonance (NMR) has become a well-established and versatile tool in numerous fields of research and in industry, but features a relatively low sensitivity which prevents solving today’s most pressing challenges in modern science. Hyperpolarization by dissolution dynamic nuclear polarization (dDNP) provides a partial solution by enhancing sensitivity 10’000-fold. However, hyperpolarized solutions are available only once (single-shot), and are contaminated and diluted. This is incompatible with most NMR experiments, except for some niche applications. HypFlow will reach the ground-breaking overall aim of providing inexhaustible (multi-shot) and pure (unpolluted and undiluted) hyperpolarization, thus truly compatible with NMR by: 1) designing and building a pulsed-DNP freeze&flow polarizer, 2) integrating the use of hyperpolarizing matrices with polarized electrons, and 3) validating multi-scan applications in metabolomics, drug discovery, and chemistry. Liquid NMR samples will freeze in the HypFlow system where high levels of polarization will be generated, will then melt and flow toward the spectrometer, and will recirculate repeatedly. This will offer, for the first-time, inexhaustible and pure hyperpolarization with a 10’000-fold boost in sensitivity. The PI has a unique combined leading expertise in most recent instrumental, methodological and chemical developments in dDNP that will empower him to tackle the scientific challenges of HypFlow. HypFlow will deepen the fundamental scientific knowledge of nuclear and electron spin polarization generation, transfer, and relaxation phenomena. It will enable detection of hyperpolarized samples in a fully compatible way with a broad range of NMR applications, radically transforming and democratizing the practice of hyperpolarized NMR in research laboratories and industries.

Keywords: nuclear magnetic resonance,hyperpolarization,dynamic nuclear polarization
HYCELAND : Iceland Small Hydrogen Valley (HYCELAND)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: United Kingdom,Iceland,France
Call: Small-scale Hydrogen Valley (HORIZON-JTI-CLEANH2-2024, 2024)
Start date: 2025-05-01
End date: 2029-10-31
Duration (months): 54.0
Total project cost (EUR): 12705074.29
EU funding (EUR): 8997502.0
Participants: 16
Project status: SIGNED

HYCELAND is a Small Hydrogen Valley project in Iceland, which will produce hydrogen to serve end users across mobility, industry and power sector applications. The project is being led by Landsvirkjun (the national power company of Iceland) in partnership with Olis (a well established fuel retailer in Iceland), who have established a consortium of partners to cover the entire value chain.