Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Real Life Environment with Pilot State Monitoring Systems (REPS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Italy
Call: Concept for Pilot State Monitoring system operation in commercial aviation (H2020-CS2-CFP11-2020-01, 2020)
Start date: 2021-01-01
End date: 2023-06-30
Duration (months): 30.0
Total project cost (EUR): 941037.5
EU funding (EUR): 799475.0
Participants: 3
Project status: SIGNED

Airline pilots today consider a variety of information sources to ensure a comprehensive flight preparation and a safe flight operation. In times of an increasingly complex working environment, the workload for pilots increases permanently. The likelihood of miscalculations as a consequence of poorly prepared information is increasing there as well. This project aims to validate Pilot State Monitoring system in the cockpit which is able to provide crucial feedback of the pilot state to yield faster decision making, reduce the probability of pilot errors and enhance the fatigue risk management. The project will collect operational data and experience during nominal operations for both short and long-haul flights. It will support the development of associate concept of operations. This concept will address envisioned use cases, identify benefits, operational constraints, risks and mitigation strategies and evaluate possible future use of the system from end users such as airlines, aircraft operators and training centres. The REPS project team consists of three partners with acknowledged expertise in the aviation domain. Air Traffic Management processes and technologies with special focus on support systems for cockpit-crews are core competencies of the Institute of Flight Guidance at TU Braunschweig. TU Braunschweig will lead the consortium. The second partner, Deep Blue SRL, has a good and acknowledged track record in research on human factors as well as in validation and evaluation activities. The third partner is a start-up called CACTUSpartners GmbH. CACTUS has been founded in 2019 by two active airline pilots with consulting background and two scientists to combine operational airline expertise with scientific knowledge in all aviation domains. The partners will sub-contract Etihad Airways as airline to install and test the pilot state monitoring devices.

Keywords: pilot state monitoring,airline operations,aircraft cockpit
New approaches for community-driven sustainable mobility innovations at neighbourhood and urban district level (Cities-4-People)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Greece,Türkiye,Hungary,Belgium,Greece,Netherlands,United Kingdom,United Kingdom,Denmark
Call: New ways of supporting development and implementation of neighbourhood-level and urban-district-level transport innovations (H2020-MG-2016-Two-Stages, 2016)
Start date: 2017-06-01
End date: 2020-11-30
Duration (months): 42.0
Total project cost (EUR): 3999937.5
EU funding (EUR): 3999937.5
Participants: 14
Project status: CLOSED

People Oriented Transport and Mobility (POTM) holds a great promise for tackling some of the most persistent urban and peri-urban sustainable mobility challenges of common interest to EU cities. Even though researchers, practitioners and policy makers are aware of this potential, the current research and innovation framework is plagued by a surprising lack of evidence and transformative POTM solutions. Cities-4-People brings together a multidisciplinary consortium to introduce a community-driven POTM framework based on participatory, inclusive and transparent innovation processes. We incorporate collective awareness and open innovation to understand the real needs of EU citizens and co-create new mobility solutions with them, harnessing digital and social innovation. Based on a local community setting and supported by cross-disciplinary teams and a comprehensive suite of collaborative technologies (both online and offline), citizens along with public and private city stakeholders will co-develop concepts and endorse concrete solutions – inspired by growing mobility trends (e.g. shared mobility and connected mobility). The best solutions will be put to the real test in a thorough pilot and scale up program in 5 different EU urban areas with rich diversity in terms of size, population density and socio-economic context. In parallel, the project will introduce an open process to co-develop a common Core Outcome Set of definitions, metrics, indicators and methods to guide POTM impact assessment and place, for the first time, the citizen into the equation. We will use this common baseline throughout our evaluations together with some less traditional techniques (e.g. people as sensors, real time user feedback). We believe that this work will act as the first open standard in POTM and will open up the way not only for the structuring of this young research field, but also for the attraction of interest from entrepreneurs, companies as well as investors (social or not).

Keywords: mobility,sustainability,social innovation,citizens engagement,infrastructure design and planning,governance,communities,transport
SWIM Technical Infrastructure (PJ17 SWIM-TI)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Austria,Germany,Germany,Spain,Ireland,Italy,Germany,Belgium,Croatia,Hungary,Lithuania,Romania,Slovakia,Sweden,Romania,Norway,Belgium,Poland,France,France,France,France,France,Czechia,Czechia,Netherlands,United States,Denmark,United Kingdom,United Kingdom,Portugal
Call: SWIM Infrastructures (H2020-SESAR-2015-2, 2015)
Start date: 2016-11-01
End date: 2020-03-31
Duration (months): 41.0
Total project cost (EUR): 16221751.94
EU funding (EUR): 9033141.77
Participants: 39
Project status: CLOSED

Single European Sky – the vision is clearly described in the European ATM Master Plan. Reaching the goals for the European Airspace is only possible with focused and extensive technical developments on European level. One of the major challenges is making sure every actor in ATM has the right information at the right time and in a consistent manner, as ATM information is the key to many concepts developed in SESAR. Extensive research was conducted in SESAR 1 under this topic called “System-Wide Information Management (SWIM)”. Our project addresses the technical infrastructure of SWIM as an enabler to the other projects. It will build on the SESAR 1 research results by integrating the aircraft on the one hand and the military stakeholders on the other hand into the SWIM infrastructure. The aircraft is an essential provider of information with regard to the flight trajectory and an information user, e.g. for meteorological information, which ensures a more efficient flight progress. Integration with the military will contribute to a more complete picture of the traffic situation. Both aspects will improve trajectory based operations and thus improve the experience for the passengers. The common runtime registry will extend the capability of the SESAR 1 SWIM design-time (static) registry by acting as a real-time directory, used to dynamically discover and connect to deployed SWIM services, suited best for the current request during operation, like the internet’s Domain Name Service. This will provide the consumers with an efficient access to the SWIM services, thus facilitating cost-effective operation. The companies involved in this project are the only ones that can deliver this kind of result. Not on their own – but as the unique cooperation between air navigation service providers and air and ground industry. This ensures the capabilities not only to come up with the concepts and develop prototypes, but also to provide sustainable results usable throughout Europe.

Keywords: swim,interoperability,data exchange,icao,standardization,civil military,air ground,registry,enabler,infrastructure,communication,protocol,middleware,collaboration,cybersecurity
International Digital Health Collaboration for Preventive, Integrated, Independent and Inclusive Living (IDIH)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Coordination and support actions
Countries involved: Italy,Germany,China,Korea, Republic of,Greece,France,France,United States,Japan,Canada
Call: Support to further development of international cooperation in digital transformation of health and care (H2020-SC1-DTH-2018-1, 2018)
Start date: 2019-05-01
End date: 2022-04-30
Duration (months): 36.0
Total project cost (EUR): 2437771.11
EU funding (EUR): 1998038.75
Participants: 12
Project status: CLOSED

The aim of the IDIH project is to promote and increase international cooperation to advance digital health in the EU and key strategic countries to support active and healthy ageing through innovation. IDIH will identify shared priorities and set up a Digital Health Transformation Forum as a long-lasting and expert-driven catalyst to foster collaboration between the EU and five strategic third countries, i.e. Canada, China, Japan, South Korea and the USA. Overall, the IDIH project sets 4 targeted objectives. First, to support the definition of common priorities to enhance strategic international cooperation in digital health in line with policy orientations through a thorough analysis of priorities in Europe and each of the strategic third countries and close involvement of the relevant funding agencies. Secondly, to provide specific contributions to the international dialogue in digital health with the creation of a Digital Health Transformation Forum acting as umbrella for high-level experts in four thematic groups (Preventive care, Integrated care, Independent and connected living and Inclusive living). Thirdly, to facilitate the exchanges between RTI stakeholders from the EU and strategic third countries in digital health through international workshops, promotion of cooperation opportunities (guidebook, webinars, helpdesk) and joining forces with other initiatives. Fourthly, to foster international collaboration for digital solutions for health care benefitting the society and industry through networking and co-creation sessions in RTI workshops. The consortium partners have complimentary expertise, including healthcare & digital health, IT, H2020 project management, technology transfer etc. The consortium has close links to funding authorities and actors in the Digital Health Industry in all countries/regions and have wide networks in the community. As such, the consortium possesses expertise and tools to successfully realise the objectives of the project.

Keywords: ehealth,international cooperation,digital health transformation,co creation,capacity building,awareness raising,active and healthy ageing,networking and stakeholder mobilisation
A minimally invasive, outpatient treatment for Gastroesophageal Reflux Disease (GERD), resulting in permanent relief from both GERD symptoms and life-long drug dependency (G125)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2019-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Gastroesophageal Reflux Disease (GERD) is a digestive disorder associated with symptoms such as heartburn and regurgitation, and reflux of normal gastric content like gastric acid and digestive enzymes. GERD is caused by a loss of integrity of the gastro-esophageal barrier known as the 'lower esophageal sphincter' (LES). This condition is one of the most common gastroenterological diagnosis in the European Union, with an estimated 15-20 Million daily sufferers. GERD today is typically treated with medications such as proton pump inhibitors (PPIs). Unfortunately, these anti-acid medications only ‘mask’ GERD symptoms, cause severe side-effects long-term, and about 20% of patients are non-responders. Importantly, they do not treat/cure the underlying root cause of acid reflux. For people who have severe GERD and do not respond to medication, invasive surgical intervention remains the only option. G125 is the least invasive outpatient treatment for Gastroesophageal Reflux Disease (GERD). It is a permanent injectable bulking agent for the endoscopic treatment which enables cell growth in the Lower Esophagal Sphincter (LES), thereby providing long term cure for the debilitating symptoms of GERD. G125 uses a tissue-friendly (biocompatible) microspheres made of Polymethylmethcrylate (PMMA) suspended in bovine collagen and an Elongated Flexible Syringe (EFS) which consists of an elongated catheter and a transition bore needle. The PMMA microspheres provide a permanent scaffold for stimulated fibro-vascular tissue ingrowth in the affected area. During the phase 1 project, a go-to-market strategy and a supply chain will be established, as well as further development plan will be drafted. Within the overall innovation project AscentX Medical will refine the endoscopic injection procedure, perform a 12 month clinical trial with 60 patients followed by a scale up of the production to prepare for commercialization.

Keywords: esophageal stimulation,reflux prevention,minimally invasive,microspheres,collagen,natural,bulking
DYNAMIC BRAIN FUNCTION: Towards the Understanding and Treatment of Brain Disorders (DYNABrain)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Portugal
Call: ERA Chairs (H2020-WIDESPREAD-2018-2020-6, 2019)
Start date: 2021-01-01
End date: 2026-12-31
Duration (months): 72.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

DYNABrain aims to develop, extend and fully unlock the research potential of the Center for Neuroscience and Cell Biology (CNC), through the implementation of a new interdisciplinary research line in the field of Systems Neuroscience that will synergise and uplift CNC’s flagship research domain, Neuroscience, to the EU/ERA level. It will capitalize on CNC’s installed capacity and research excellence in cellular and molecular Neuroscience and Brain Diseases, and establish an ERA Chair in Systems Neuroscience to incorporate the systems-level of understanding brain function and pathology in CNC core research activity. The field has gained center-stage due to recent advances in technology for recording and manipulating neural circuits at single-cell resolution and in vivo, creating new opportunities to investigate how neuronal networks give rise to behavior, and how alterations in their activity relate with neuropsychiatric diseases and with early stages of neurodegenerative disorders. It will greatly contribute to the development of pioneer strategies to treat brain diseases, or to delay/reduce their socio-economic burden. DYNABrain will thus recruit a research team in Systems Neuroscience headed by an outstanding scientist in the field with proven leadership and management competence, to transversally impact on CNC core research activities and synergise its complementary research areas. The CNC Neuroscience ecosystem, immersed in the large R&I network of the University of Coimbra, provides the right setting for the successful integration of the ERA Chair. An innovative International PhD Programme in Integrative Neuroscience will be created powered by the ERA Chair expertise that will boost the competitiveness of CNC graduate school and train the next generation of Neuroscientists. A group of highly prestigious and influential European and US Neuroscientists, with a clear view of the current challenges in Neuroscience, will advise on the different steps of the project.

Keywords: integrative neuroscience,brain health,frontier research,translational research,teaching,advanced training,eu charter and code for researchers
REthinking Future Infrastructure NETworks (REFINET)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Spain,Italy,Spain,Belgium,Slovenia,France,France,United Kingdom
Call: Smarter design, construction and maintenance (H2020-MG-2014_SingleStage_B, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 998235.51
EU funding (EUR): 998235.51
Participants: 10
Project status: CLOSED

Launching a European long-term ambition and initiative to increase the overall performance of multimodal transport infrastructures, the REFINET CSA intends to 1) create a sustainable network of European and international stakeholders’ representatives of all transport modes and transport infrastructure sectors, 2) deliver a shared European vision of how to specify, design, build or renovate, and maintain the multimodal European transport infrastructure network of the future along with innovative processes so as to enhance the effectiveness of the sector, and 3) elaborate a Strategic Implementation Plan with a comprehensive set of prioritised actions to made the REFINET vision a reality – as well as providing private and public decision makers with a set of up-to-date recommendations and guidelines (including good practices and lessons learnt) for strategic actions and required levels of cooperation between all stakeholders. REFINET will consider two complementary scenarios, namely maintenance and upgrading of existing transport infrastructures, and development of new transport infrastructures. REFINET will contribute to create a European-wide consensus on where to focus in terms of research and innovation to improve the productivity of the assets (reducing maintenance costs, extending the life span…) and reduce drastically traffic disruptions of transport flows from inspection, construction and maintenance activities, and to accommodate increasing/changing traffic demand. Thus, REFINET will pave the way to enhanced technology integration and transfer and mass-market development for innovative materials, components, systems and processes supporting the pan-European generalisation of advanced multimodal infrastructures, handling the demand within various industrial sectors and help match the EU-2020 Strategy, and achieve goals of main stakeholders. The REFINET consortium is made of 8 partners from 5 European countries (Spain, France, Italy, Belgium, United Kingdom).

Keywords: transport and infrastructure operators networking
Systematic profiling of molecular changes during prion disease progression (Prionomics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Prion diseases are fatal neurodegenerative diseases and are caused by proteinaceous infectious particles termed prions. The infectious agent of prion diseases has been identified decades ago, but the actual cellular processes that subsequently cause neurons to degenerate remain poorly understood. I propose the systematic analysis of molecular changes in various organs from prion-infected mice. I will profile translation rates and mRNA abundance on a genome-wide scale via ribosome profiling and RNA sequencing, respectively. This will allow me to identify molecular changes during prion disease progression and to decipher the relative contributions of differential transcriptional and translational regulation to them. By relating these changes to prion titers and clinical symptoms I will establish correlations between molecular changes and disease progression. This will identify single genes as well as gene networks that are linked to disease pathology. The analysis of various organs at multiple time points following prion inoculation will enable me to dissect the dynamics of disease progression and the role and interplay of the different organs in pathophysiology. I will further study the causal role of identified candidate genes in prion pathology. To this end, I will investigate the effect of their knock-down and knock-out on prion clearance, replication and toxicity, using a previously established fully automated digital prion infectivity assay. This approach will identify a comprehensive list of genes that are differentially regulated during prion disease progression and that are important for different aspects of prion pathogenesis. This will not only help to better understand the manifestation of prion disease and other neurodegenerative diseases but also provide potential starting points for the development of targeted therapeutic interventions.

Keywords: prion disease,rna regulation,ribosome profiling,mrna sequencing,molecular changes in neurodenerative diseases
The neuroenergetics of memory consolidation – hybrid PET/MR imaging of the default mode network (SUGARCODING)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-07-01
End date: 2024-06-30
Duration (months): 72.0
Total project cost (EUR): 1499403.74
EU funding (EUR): 1499403.74
Participants: 1
Project status: SIGNED

Since its discovery more than a decade ago, the most studied network in the human brain remains a paradox. The default mode network (DMN) is most active during the resting state and deactivates once subjects engage in goal directed behavior. Although reported in hundreds of studies using functional magnetic resonance imaging (fMRI), the function of the DMN is still unknown. I hypothesize that memories are consolidated in the DMN during resting state, a process that is interrupted once we engage in cognitive processing. This hypothesis is based on two complementary and recent findings. First, brain regions involved in encoding of novel or retrieval of consolidated memories strongly resemble regions of the DMN. Second, the DMN consumes most glucose during resting state as revealed by positron emission tomography (PET). Importantly, energy in the brain is mainly dedicated to neuronal signaling and synaptic plasticity related to memory consolidation. To test my hypothesis, I will use hybrid PET/MR imaging to simultaneously study fMRI activity and energy metabolism of the DMN during episodic memory processing. Integrating this novel imaging approach with my recently developed brain connectivity methods, I will (i) identify the metabolic baseline of fMRI-deactivations in the DMN, (ii) track the metabolic demand and directional connectivity in the DMN during memory consolidation, and (iii) evaluate non-invasive brain stimulation as a therapeutic option to modulate memory consolidation. The DMN is massively disturbed in psychiatric disorders such as Alzheimer’s disease, anxiety and affective disorders. SUGARCODING aims at uncovering memory consolidation as a universal function of the DMN that seems to critically orchestrate the human mind and its pathological deviations. ...

Keywords: episodic memory,default mode network,hybrid pet,mr imaging