Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A digital edition of Greek and Roman Sculptors’ signatures (323 BCE-138 CE) (SculpSi)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: SIGNED

SculpSi aims at reconstructing the lives and the works of Greek and Roman sculptors between the Hellenistic period and the reign of Hadrian (323 BCE-138 CE) in the areas corresponding to Roman Italy and the provinces of Achaia and Asia. SculpSi focusses on sculptors’ signatures, taking them as a source of information and a starting point for reconstructing their professional careers: signatures open up many research paths that have yet remained unexploited: their wording, their position on statues or bases, palaeographic dating, language and dialect, etc. They can also help us to reconstruct the work of individual sculptors, attribute them specific artworks and track their mobilities in the Mediterranean. SculpSi will be the first systematic study on sculptors’ signatures between 323 CE and 138 CE: the analysis will be carried out on a corpus of ca. 550 signatures, and will be based on bibliographic data and, whenever relevant, autoptic study; such data will be used to feed Polycles, a prosopographic database already created by the LIMC team at my host institution, but still awaiting launching. The project breaks down disciplinary barriers by combining art history, epigraphy, archaeology, and digital humanities and posing theoretical questions (e.g. role of the artist within society, the idea of authorship) which go well beyond Classical studies. The database -only one of the research products of Sculpsi- will constitute a perennial gate for scholars and students of several disciplines, giving access to data scattered in different parts of Europe and beyond and to the first English and French translations of many inscriptions. Besides being trained in digital humanities, the researcher will develop a unique expertise in Epigraphy and ancient Art History, filling a gap between disciplines which rarely communicate. Collaborations with international museums and academic institutions will open up several opportunities for the researcher, both in France and abroad.

Keywords: digital humanities,greek and roman sculpture,iconography,epigraphy,classical antiquity,art criticism
Revivable insect preservation technologies pausing the life cycle of insects at egg or neonate larvae stages for empowering the insect farming industry (FreezeM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Israel
Call: Green Deal innovations for the Economic Recovery (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 3301750.0
EU funding (EUR): 2293725.0
Participants: 1
Project status: CLOSED

FreezeM is making insect farming sustainable, steady & scalable by providing ready-to-use BSF eggs or neonates to rearing facilities worldwide. Through its novel technologies - insect eggs cryopreservation and suspended animation of neonate larvae, FreezeM enables for the first time to decouple the breeding (reproduction) from the rearing (larva growth & processing) steps in the insect protein production supply chain, and by that makes insect farming more efficient and accessible to everyone: large-scale factories, SMEs, or sole farmers. FreezeM creates new products in the market: ready-to-use insect eggs and neonates with extended shelf-life to be shipped worldwide, enhancing the insect protein industry. The novel patent-pending technology retains the insects’ traits, allowing them to complete their life cycle and function normally after exiting the preservation state. This makes FreezeM the equivalent of an agriculture seed company in the emerging market of insect farming.

Keywords: insects,cryptopreservation,black soldier fly,bsf,ecology,environmental protection
Marine annelids as a model for disentangling the molecular basis underlying the evolution of reproductive strategies and reproductive timing (MOM-OR-DAD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-04-02
End date: 2026-04-01
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

Alternative developmental and reproductive programs provide powerful sources of adaptive variation, which greatly enhances survival in changing environments. Yet, how divergent reproductive strategies and traits evolve remains poorly investigated particularly in the ocean, where the dramatic effects of climate change and anthropogenic impact on reproductive dynamics threaten entire animal communities. For this, I plan to close this knowledge gap by investigating the molecular and genomic basis underlying the divergent reproductive strategies and reproductive timing in Platynereis marine bristleworms. These animals are easy to breed in laboratory conditions, are genetically-accessible, and display a kaleidoscopic diversity of reproductive traits in closely-related species. Specifically, I plan to: 1) dissect the molecular mechanisms of the drastically divergent reproductive strategies of the sister species P. dumerilii and P. massiliensis, and 2) decode the genomic basis of alternative lunar reproductive periodicity in Platynereis species. Thus, I will combine my experience in working on the reproduction and chronobiology of these models with evolutionary genetics, population and comparative genomics, functional genomics and transcriptomics strategies mastered in the host lab. On one hand, I will provide ground-breaking insights on how molecular machinery can be drastically rewired generating novel and adaptive combinations of reproductive traits. On the other, I will shed light on the elusive molecular nature of lunar reproductive periodicity, a widespread phenomenon particularly in the marine environment, and its evolution. Currently, endocrine disruption and light pollution are severely affecting animal sexual development and reproductive timing, respectively, challenging the conservation of entire ecosystems. In this context, this research will also provide fundamental resources to better understand their effects on the marine environment

Keywords: reproductive strategies,reproductive timing,invertebrates,platynereis
Social Sciences and Humanities for Climate, Energy aNd Transport Research Excellence (SSH CENTRE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Coordination and support actions
Countries involved: Norway,Italy,Belgium,Czechia,Slovenia,Spain,France,Netherlands,United Kingdom,Hungary
Call: Strengthening Social Sciences and Humanities (SSH) research communities in climate, energy and mobility disciplines (HORIZON-CL5-2021-D2-01, 2021)
Start date: 2022-09-01
End date: 2026-02-28
Duration (months): 42.0
Total project cost (EUR): 2305696.25
EU funding (EUR): 2305696.0
Participants: 14
Project status: SIGNED

The Social Sciences & Humanities for Climate, Energy aNd Transport Research Excellence (SSH CENTRE) project brings together 13 leading organisations from across the EU, including: 3 universities, 4 research institutions, 2 stakeholder network organisations, and 4 R&I and communications SMEs. Our partners bring world-leading expertise across SSH and STEM disciplines applied to climate, energy and mobility, covering neutrality, community-led initiatives, heating and cooling, circular economy and sufficiency, and digital technologies. Partners will reach 228,880+ stakeholders by leveraging their significant experience in transdisciplinarity and citizen engagement, and networks that span academia, policymakers at various levels, the private sector, civil society and citizens. Our objectives directly address the call challenge with an aim to support cross-sectoral collaborations and empowerment of citizens and networks towards the development of socially innovative solutions for the EU’s climate transition. Issues related to Open Science, inclusivity and diversity – especially with regards Southern and Eastern Europe and different career stages – are at the heart of the project. SSH CENTRE will meet its objectives through a set of 7 carefully-designed Work Packages. Key activities involve: development of novel SSH-STEM collaborations to facilitate the delivery of the EU Green Deal; SSH knowledge brokerage to support regions in transition; and the effective design of strategies for citizen engagement in EU R&I activities. Outputs include action-led agendas and building stakeholder synergies through regular Policy Insight events. The high-profile virtual SSH CENTRE, and its 660+ members, will thus represent a ‘go-to' gateway for Cluster 5 SSH research excellence, delivering inclusive governance and engagement approaches. The Centre will generate and share best practice for SSH policy advice, overcoming fragmentation to accelerate the EU’s journey to a sustainable future.

Keywords: transitions transdisciplinary epistemic cultures research policy brokers citizen engagement climate energy mobility cities research and innovation eu green deal horizon europe eu set plan
interSectIonal iNClusion in delibeRation and participatiON with Youth (SINCRONY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Italy,Switzerland,Portugal,France,Spain,Denmark,Finland,Austria,United Kingdom
Call: Intersectionality and equality in deliberative and participatory democratic spaces (HORIZON-CL2-2023-DEMOCRACY-01, 2023)
Start date: 2024-01-01
End date: 2027-06-30
Duration (months): 42.0
Total project cost (EUR): 2450313.75
EU funding (EUR): 2450313.75
Participants: 9
Project status: SIGNED

SINCRONY aims to ensure the meaningful inclusion of youth who experience social disadvantage and marginalisation in deliberative and participatory processes (DPP). The project will target the factors and processes responsible for reproducing political inequalities in youth engagement in deliberative and participatory processes based on intergenerational and intragenerational power imbalances and youth intersectional positionalities. The goal is to offer policymakers, public servants, researchers, teachers, youth workers, facilitators of deliberative processes, and youth CSOs concrete instruments, guidelines, and solutions to renovate deliberative and participatory practices implemented in public governance and schools. The consortium of nine partners, consisting of seven universities, the ALDA European network of local democracies, and an SME focusing on communication and dissemination, will contribute multidisciplinary and multi-methodological expertise in psychology, education, sociology, political science, gender studies, social research, intersectionality, and media analysis. A Stakeholders’ Collaborative Network, including expert advisors, local municipality representatives, schools, civil society, and youth organisations, will also be engaged throughout the project. Together, they will: (a) enhance the inclusivity of deliberative practices in two local municipalities (in Italy and Finland); (b) design, test, and deliver an innovative, co-constructed intersectional approach called the Intersectional Participatory Action Research-and-Deliberation, piloted in seven local municipalities and four schools (in Italy, Portugal, the UK, and Denmark); (c) design participatory formats; (d) create tools; (e) define ethical guidelines. By improving the democratic quality, inclusiveness, effectiveness, and legitimacy of deliberative and participatory processes, the project will contribute to greater social justice for all youth.

Keywords: youth inclusion,social justice,intersectional approach,youth agency
Advancing a vaccine targeting genetic amyotrophic lateral sclerosis (C9orf72 ALS) to the clinical stage (GA-VAX)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Netherlands
Call: EIC Transition Open 2021 (HORIZON-EIC-2021-TRANSITIONOPEN-01, 2021)
Start date: 2022-06-01
End date: 2026-03-31
Duration (months): 46.0
Total project cost (EUR): 2499810.0
EU funding (EUR): 2499810.0
Participants: 3
Project status: SIGNED

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is triggered by protein aggregation in the brain and spinal cord motor neurons that leads to respiratory failure within 2-5 years. The best available drug extends life by ~3 months. ALS strikes about 1 in 500 people mostly for unknown reasons, but 5-10% of cases in Caucasians are caused by a mutation in the C9orf72 gene. We have shown that this mutation leads to expression of large aggregating poly-Glycine-Alanine (poly-GA), which triggers downstream pathology. We developed a poly-GA peptide vaccine that reduces aggregates and largely prevents motor deficits in a mouse model. When starting vaccination in already symptomatic mice, our vaccine reduces neuronal damage to a similar extent. Since regular lifelong vaccination is required to maintain sufficient antibody levels, GA-VAX is an attractive business case in the orphan disease space with ~2500 prevalent C9orf72 ALS cases in the US, DE, IT, FR, ES, UK. ~9000 mutation carriers at risk to develop disease within 10 years could benefit even more from our approach. A joint venture established by Intravacc and DZNE will bring together the right resources to advance this promising treatment approach towards clinical evaluation. Intravacc contributes know-how for production and clinical development of peptide/carrier conjugate vaccines, DZNE provides in depth knowledge of disease pathology as well as all necessary model systems and assays. Together we will setup GMP manufacturing for the antigen and conduct pivotal toxicology and efficacy studies in animals in accordance with regulatory requirements by EMA and FDA. This will allow us to compile a clinical trial application in C9orf72 ALS patients. In addition, we will use this data-package to raise capital for the phase 1 trial from a patient organization or investor for further de-risking or, preferentially, directly partner with a larger pharma company to bring GA-VAX to the market.

Keywords: amyotrophic lateral sclerosis,vaccination,immunotherapy,drug development,business development,investment readiness
Unlocking RI potential with Scalable AI and Data (RI-SCALE)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Technology and infrastructures
Action type: Research and Innovation actions
Countries involved: Netherlands,Germany,Austria,Italy,Greece,Sweden,Czechia,Portugal,Türkiye,United Kingdom,Spain,Switzerland,Finland
Call: R&D for the next generation of scientific instrumentation, tools, methods, solutions for RI upgrade (HORIZON-INFRA-2024-TECH-01, 2024)
Start date: 2025-03-01
End date: 2028-02-29
Duration (months): 36.0
Total project cost (EUR): 9998828.75
EU funding (EUR): 9998828.75
Participants: 29
Project status: SIGNED

Data and AI are the fuel of scientific discoveries, and Research Infrastructures (RIs) are at the forefront of this process, generating massive and increasingly more complex datasets. However, the growing size, diversity, and velocity of research data and software demand large-scale infrastructures and technical expertise from those on the user side. RI-SCALE will address this challenge by delivering Data Exploitation Platforms (DEPs). These scalable environments will co-host scientific data with preconfigured AI frameworks and models on powerful compute resources and unlock full data and AI potential for scientific users, RI operators and industry. RI-SCALE will design and develop the DEP technology with four RIs: ENES, EISCAT, BBMRI and Euro-BioImaging. DEP instances will be deployed for environmental and life sciences, validating the technology through 8 scientific and 4 technical use cases. These will run on national e-infrastructures from the EGI Federation and (pre)exascale machines from EuroHPC. RI-SCALE will collaborate with Destination Earth, EUCAIM cancer images data space, Copernicus Data Space Ecosystem, EOSC and Gaia-X to ensure interoperability within the broader landscape. The project will also facilitate industry and university collaborations, provide training and consultancy events to increase the uptake of AI technologies by additional RIs and explore sustainable DEP operation models for RI communities.

Keywords: ris,scale,ai,data,data exploitation platform
Biogeochemical impact of land-use intensification and its legacy effects on tropical forest recovery through cation limitation (FORECAT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Biogeochemistry directs ecological recovery of secondary forests, and thereby impacts the rate of carbon accumulation along succession. Recent observations suggest that cations (calcium, magnesium, potassium) limit forest productivity in the tropics, although research to date has largely focused on nitrogen and phosphorus. Moreover, the intensification of land-use change impacts cation availability at the onset of succession, likely further constraining regrowth rates of secondary forests. FORECAT (legacy effects on tropical FOrest REcovery through CATion limitation) strives to understand the fundamental role of cations in limiting productivity of secondary forests in the tropics, and to quantify how land-use change and its intensification affect cation limitation on forest recovery rates. FORECAT will integrate observational, experimental and modelling approaches. This work will be conducted along tropical forest successional gradients and land-use intensity gradients, to disentangle how the legacy land-use history affects recovery trajectories through cation cycling. Additionally, a large scale nutrient addition experiment in different-aged forest will further uncover the role of changed nutrient availability along succession. The field-based data will constitute the most detailed nutrient mapping – including cations – of secondary tropical forests to date. These data will then be integrated in a state-of-the-art biogeochemical model to provide projections of long-term effects of different land-use change scenarios on forest recovery in the tropics. Due to the sheer magnitude of projected land-use intensification in the tropics, cation limitation on the carbon uptake rate of secondary forest regrowth will impact global carbon cycle. Furthermore, FORECAT will drastically improve our land-scape scale understanding of forest regrowth in the tropics, and will set the stage to inform managers and decision makers on optimal and sustainable land-use change planning.
Raman Active, Smart Diatom Frustules as Next Generation Multimodal Theranostics for Safe and Superior Colorectal Cancer Treatment (DIASHUTTLE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2027-01-31
Duration (months): 43.0
Total project cost (EUR): 235737.6
EU funding (EUR): 235737.6
Participants: 2
Project status: SIGNED

Colorectal cancer accounted for 12.7% of all new cancer diagnosis and 12.4% of all deaths due to cancer in European Union in 2020. Despite the advances in therapeutics, it is the most recurrent tumors in humans and third common cause of cancer-related deaths worldwide. The current treatment options include chemotherapy, radiation and surgery that are invasive and have side-effects. Also, the 1st and 2nd generation nanocarriers used in cancer therapy consisted of mono-component systems and failed due to lack of targeting molecules, remotely controlled therapeutics window, and patient-specific individualized platforms. The project DIASHUTTLE aims to develop a novel, next-generation, smart, multifunctional and multimodal, hybrid nanotheranostic platform consisting of biosilica extracted from living diatoms for simultaneous diagnosis, treatment, and therapy monitoring of colorectal cancer. It will combine magnetic nanoparticle core, surface deposited metallic gold nanoparticles, tumor targeting biomolecule folic acid, and natural source drug astaxanthin to facilitate different modes of therapy such as magnetically guided or ligand targeted drug delivery, magnetic hyperthermia, and photothermal therapy. It will also concurrently enable different modes of real-time monitoring such as Raman, surface enhanced Raman spectroscopy, magnetic resonance imaging, fluorescence, and photoluminescence. It is expected that the combination of different therapies will exhibit superior synergistic anti-cancer effect over monotherapy and reduce treatment delays by offering a safe and personalized approach to overcome the limitations of conventional cancer treatment. The proposed platform will lead to less toxicity due to the use of targeting molecule and natural materials, controlled drug release, and lower effective drug concentration. Additionally, the nutrient uptake and CO2 sequestration capability of diatoms will support circular bio-economy and self-sustainability.

Keywords: anti cancer,diatoms,functionalization,drug delivery,biosensing,natural resources,circular bio economy