Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ULtrafine particles from TRansportation – Health Assessment of Sources (ULTRHAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Switzerland,Finland,Finland,Norway
Call: Understanding and mitigating the effects on public health of emerging non-regulated nanoparticle emissions issues and noise (H2020-MG-2020-TwoStages, 2020)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 4322206.25
EU funding (EUR): 4037501.25
Participants: 7
Project status: SIGNED

Current legislative control of particulate matter (PM) based on ambient mass concentrations does not encompass source dependent variation in PM toxicity or the impact of high numbers of nanoparticles (ultrafine particles; UFPs) which contribute little to PM mass. UFPs may pose high risks due to their small size and high number/surface area concentrations and higher propensity to penetrate tissue barriers and reach the circulation and secondary target organs. Non-regulated nanoparticle emissions from transport sources belong to this category of high concern, and the effects of some specific emissions (e.g. particles from wear components or natural gas and jet engines) are either not sufficiently understood or remain undetected by current air quality or certification procedures. ULTRHAS will specifically address (i) the impact of different transport modes, fuel technologies and wear components, including atmospheric ageing processes, on the physicochemical characteristics of particulate and gaseous emissions; and how these processes and characteristics affects (ii) the biological responses leading to harmful effects in the lung and beyond by applying state-of-the-art emission measurement, exposure and toxicity-testing approaches under highly controlled laboratory conditions. ULTRHAS will (iii) rank the health hazards of different transport mode emissions and (iv) apply an advanced health impact assessment framework incorporating burden of disease methods to quantify baseline and policy scenario impacts for development and prioritization of mitigation measures; and (v) evaluate the future impact and acceptance of new policies on public health, taking into account social aspects. ULTRHAS will provide enhanced understanding of health threats posed by nanoparticles from different transport modes; optimize a framework for toxicity and hazard assessment of aerosols; provide guidance for prioritization of mitigation measures for future legislation on air pollutants.
DNA methylation as epigenetic clock of biological age? An experimental test in wild birds (wildEPIClock)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: SIGNED

DNA methylation (DNAm), an epigenetic effect, changes with age in a site-dependent way. DNAm score, integrating methylation state at many sites, has recently emerged as a superior marker of biological age in epidemiological studies: it predicts remaining lifespan markedly better than chronological age (CA). Identification of factors that contribute to ageing-related methylation has thereby become of importance for understanding healthy ageing. In this project, I will use a large existing set of biological samples of a free-ranging animal (jackdaw, Coloeus monedula) with known life-histories, monitored longitudinally throughout their lives, to reveal causes (experimental approach) and consequences (lifelong monitoring) of DNAm variation. By integrating expertise from evolutionary ecology, quantitative genetics and biomedicine, I will develop an epigenetic clock to build a comprehensive understanding of shifts in DNAm and their ultimate fitness consequences, unravelling extragenic mechanisms of inheritance and phenotypic evolution in an ecologically relevant setup. Specific objectives, implemented through dedicated work packages, are: O1-Groundwork: Develop an epigenetic clock of CA for wild jackdaws. Method WP1: wet-lab analyses of DNAm and identification of CpG sites where methylation changes with CA to be combined in a DNAm score of age. O2-Causes: Identify environmental and quantitative (epi)genetic causes of DNAm variation, leveraging a long-term brood size manipulation experiment that affected ageing in parents (mortality) and offspring (telomere dynamics). Method WP2: analysis of longitudinal age-corrected DNAm data and the pedigree. O3&O4-Consequences: Study the link between the DNAm and its results on life-history traits according to the manipulation (O3,WP3a). Quantify transgenerational epigenetic inheritance (O4, WP3b). Method: longitudinal data analysis of phenotypic traits and transgenerational effects to unravel consequences of variation in DNAm.

Keywords: methylation,ageing,life history,epigenetic clock,biological age,phenotypic evolution
Thirdhand Tobacco Smoke: Chemical Characterization, Human Exposure and Urinary Carcinogen Biomarkers (THSExposure)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-15
End date: 2017-09-14
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Tobacco smoking is the leading cause of preventable disease worldwide. Compared with the rest of the world, the WHO European region has one of the highest proportions of deaths attributable to tobacco. Although most of EU countries have introduced smoking bans in public places, domestic environments are still an important source of passive smoking exposure. Environmental tobacco smoke contains more than 4,000 chemicals many of which are toxic and carcinogenic and is estimated to be the cause of about 1.0% of worldwide mortality. In addition to passive inhalation, non-smokers, especially children, are also at risk through contact with surfaces and dust contaminated with residual smoke gases and particles, the so-called thirdhand tobacco smoke (THS). Despite the emerging evidence on THS harms, the specific role of THS in tobacco-related illnesses has been questioned so far by the public health community because of the poor level of characterisation of THS constituents and mechanisms of formation, as well as the lack of studies focused on human exposure. The aim of this proposal is to fill some of the important gaps on our current understanding of the chemistry, toxicology and exposure of THS, including an accurate characterisation of THS composition and the development and validation of specific human urine biomarkers of this exposure. The developed tools will be used for the monitoring of matching samples of THS from smoking and non-smoking houses and human urine from their households in order to find correlations between tobacco exposure and urine biomarkers. The final objective of the proposal is the public diffusion of the results obtained in this study as evidences of THS harms to influence in present and future health educational programs, especially addressed to smoking parents, and in present and future European health policies.

Keywords: thirdhand tobacco smoke,tobacco passive exposure biomarkers,gc ms based metabolomics,lc ms based metabolomics,urine profiling,risk assessment
SUSTAINABLE AND MARKET-ORIENTATED RECYCLING TECHNOLOGY FOR EPDM RUBBER (Smart Rubber)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Germany
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2015, 2015)
Start date: 2016-01-01
End date: 2016-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The growing utilization of ethylene propylenediene (EPDM) rubber in industrial and consumer applications, combined with increased consumer awareness surrounding solid waste recycling, has led to an increased demand for recycled EPDM rubber compounds and products. MDS Meyer GmbH is a technology-based company with extended expertise and experience in the field of technical rubber products. With DBU funding support, we have developed to TRL 6 a new secondary raw material based on an innovative, solvent-free recycling process of reactivating post-industrial vulcanized EPDM scrap material with several liquid EPDM polymers that enables significant levels of re-usage in high-quality new products in the fields of rubber gaskets, automotive industries and other technical rubber products. The recycled compound ensures the complete recycling of vulcanized EPDM waste, allowing for the substitution of up to 80% of virgin EPDM rubber, without decreasing the quality of the new products. Our solution exhibits the advantage of providing a safe and inexpensive secondary raw material basis, while reducing European Union companies’ dependency on imports of raw materials. By reducing raw materials inputs, energy requirements and CO2 emissions, our product offers a solution that complies with EU legislation, reduces environmental impact and achieves cost savings of €3 million p.a. and 3,000 tons/year of CO2. (based on a 6,000 tons/year recycling capacity). Scale-up and industrialization of the production process is the key to sustainable growth and expansion of our company. Thus, we are applying for SME Instrument Phase 1 support to elaborate an exhaustive technical feasibility study, focused on scale-up, design and industrialization of the new compound, and a detailed business plan for the commercialization of the secondary raw material. Based on these results, we will apply for Phase 2 funds, in order to carry out the envisaged scale-up, product refinement and industrialization

Keywords: our goal is the elaboration of a technical feasibility study and business plan for the development of a new business model in the field of rubber recycling industry,by implementing a
CoCoUnit: An Energy-Efficient Processing Unit for Cognitive Computing (CoCoUnit)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2025-02-28
Duration (months): 66.0
Total project cost (EUR): 2498661.0
EU funding (EUR): 2498661.0
Participants: 1
Project status: SIGNED

There is a fast-growing interest in extending the capabilities of computing systems to perform human-like tasks in an intelligent way. These technologies are usually referred to as cognitive computing. We envision a next revolution in computing in the forthcoming years that will be driven by deploying many “intelligent” devices around us in all kind of environments (work, entertainment, transportation, health care, etc.) backed up by “intelligent” servers in the cloud. These cognitive computing systems will provide new user experiences by delivering new services or improving the operational efficiency of existing ones, and altogether will enrich our lives and our economy. A key characteristic of cognitive computing systems will be their capability to process in real time large amounts of data coming from audio and vision devices, and other type of sensors. This will demand a very high computing power but at the same time an extremely low energy consumption. This very challenging energy-efficiency requirement is a sine qua non to success not only for mobile and wearable systems, where power dissipation and cost budgets are very low, but also for large data centers where energy consumption is a main component of the total cost of ownership. Current processor architectures (including general-purpose cores and GPUs) are not a good fit for this type of systems since they keep the same basic organization as early computers, which were mainly optimized for “number crunching”. CoCoUnit will take a disruptive direction by investigating unconventional architectures that can offer orders of magnitude better efficiency in terms of performance per energy and cost for cognitive computing tasks. The ultimate goal of this project is to devise a novel processing unit that will be integrated with the existing units of a processor (general-purpose cores and GPUs) and altogether will be able to deliver cognitive computing user experiences with extremely high energy-efficiency.

Keywords: computer architecture,processor microarchitecture,power aware microarchitectures,special,purpose architectures
Distributed Learning-Based Control for Multi-Agent Systems (DiLeBaCo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-07
End date: 2022-04-06
Duration (months): 30.0
Total project cost (EUR): 219875.52
EU funding (EUR): 219875.52
Participants: 2
Project status: CLOSED

Multi-agent systems offer a great potential to improve the quality of modern society life. In the near future fleets of autonomous cars will be able to reduce traffic congestion and fuel consumption while increasing road safety. With almost half of all freight being transported by road, it makes up approximately a quarter of the total EU energy consumption and accounts for 18% of the greenhouse emissions. Fuel reduction in this area will have a significant impact on the environment. One way to achieve such reductions is through platooning where heavy-duty vehicles drive close to each other to reduce their aerodynamic drag and thus increase their fuel efficiency. While autonomous driving and platooning are areas of active research, open challenges arise in complex traffic scenarios with human interactions. Another challenge is that hierarchical control design with several different layers is required. The specific goals of the project are to develop novel algorithms for the control of safety-critical multi-agent systems in real-world scenarios, to understand the role of local informational constraints on the performance and safety of such systems and to design incentives for the individual agents that lead to a desired coordination of a fleet. This way global objectives will be optimized while accounting for complex traffic situations. The scientific contribution lies in combining and extending recent results from distributed predictive control, statistical learning and game theory as well as understanding the role of informational constraints in distributed learning-based control of multi-agent systems. The developed methods will have a high impact on both industry and society. In particular, the project will enable platooning in more complex scenarios, which has the potential to reduce fuel consumption of the transportation sector by up to 10% and thus make a significant contribution to the overall energy consumption and greenhouse emissions of the EU.

Keywords: multi agent systems,learning based control,cooperative robotics
Advanced Networked Agents for Security and Trust Assessment in CPS/IOT Architectures (ANASTACIA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Ireland,Italy,Italy,Finland,Switzerland,Switzerland,Greece,France,France
Call: Assurance and Certification for Trustworthy and Secure ICT systems, services and components (H2020-DS-LEIT-2016, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 5420208.75
EU funding (EUR): 3999208.75
Participants: 16
Project status: CLOSED

The main objective of the ANASTACIA is to address the constant discovery of vulnerabilities in ICT components providing assurance that ICT systems are secure and trustworthy by design. To this end, ANASTACIA will research and develop a holistic security framework, which will address all the phases of the ICT Systems Development Lifecycle and will be able to take autonomous decisions using new networking technologies (SDN/NFV), and dynamic security enforcement and monitoring methodologies and tools. The ANASTACIA framework will include a comprehensive suite of tools and enablers: - A security development paradigm based on the compliance to security best practices and the use of the security components and enablers. - A suite of distributed trust and security components and enablers, able to dynamically orchestrate and deploy user security policies and actions within complex and dynamic CPS and IoT architectures. - Online monitoring and testing techniques that will allow more automated adaptation of the system to mitigate new and unexpected security vulnerabilities. - A holistic Dynamic Security and Privacy Seal, combining security and privacy standards and real time monitoring and online testing. This will provide quantitative and qualitative run-time evaluation of privacy risks and security levels, which can be easily understood and controlled by the final users. ANASTACIA results will be driven and demonstrated in three high impact Use Cases: Mobile Edge Computing, Smart Building and IoT networks. Bringing together leading partners with wide-ranging expertise, the ANASTACIA Consortium will combine the philosophy and business models of communication technologies with inherently integrated security and privacy solutions, creating a security framework where the end users will be able to control their security and privacy policies enforcement, and application developers, in particular SMEs, will find an open and sustainable ecosystem for secure SLCD.
Atmospheres across the Universe (ATMO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2023-07-31
Duration (months): 66.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Which molecules are present in the atmosphere of exoplanets? What are their mass, radius and age? Do they have clouds, convection (atmospheric turbulence), fingering convection, or a circulation induced by irradiation? These questions are fundamental in exoplanetology in order to study issues such as planet formation and exoplanet habitability. Yet, the impact of fingering convection and circulation induced by irradiation remain poorly understood: - Fingering convection (triggered by gradients of mean-molecular-weight) has already been suggested to happen in stars (accumulation of heavy elements) and in brown dwarfs and exoplanets (chemical transition e.g. CO/CH4). A large-scale efficient turbulent transport of energy through the fingering instability can reduce the temperature gradient in the atmosphere and explain many observed spectral properties of brown dwarfs and exoplanets. Nonetheless, this large-scale efficiency is not yet characterized and standard approximations (Boussinesq) cannot be used to achieve this goal. - The interaction between atmospheric circulation and the fingering instability is an open question in the case of irradiated exoplanets. Fingering convection can change the location and magnitude of the hot spot induced by irradiation, whereas the hot deep atmosphere induced by irradiation can change the location of the chemical transitions that trigger the fingering instability. This project will characterize the impact of fingering convection in the atmosphere of stars, brown dwarfs, and exoplanets and its interaction with the circulation in the case of irradiated planets. By developing innovative numerical models, we will characterize the reduction of the temperature gradient of the atmosphere induced by the instability and study the impact of the circulation. We will then predict and interpret the mass, radius, and chemical composition of exoplanets that will be observed with future missions such as the James Webb Space Telescope (JWST).

Keywords: atmospheres,stars,brown dwarfs,exoplanets,numerical simulations