Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Unique Virtual Environment where Healthcare Professionals Can Find the Support that They Need for an Adequate Use of Pharmaceutical Products (DOCTRINA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Slovenia
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-05-01
End date: 2017-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

For pharmaceutical products to work effectively, they need to be used properly. In Europe, 50% of patients fail to adhere to the prescribed regime, incurring in € 125 billion costs. Poor patient adherence is often the result of poor management at the practice level. Indeed, the correct use of pharma products begins with the prescription by doctors and proper guidance from pharmacists. Therefore, it is important that pharma companies provide these professionals with the education they need, anywhere and anytime. Pharma companies have traditionally relied on sales representatives and agents that pay visits to healthcare professionals. However, this method is time consuming, costly, extremely inefficient and difficult to schedule with the busy healthcare professionals. Importantly, professionals lack the means to communicate back with the pharma company. Despite this acknowledged inefficiency, agents are still the best alternative available right now in the market. In response, we have created DOCTRINA, a unique and cost-effective ICT platform through which pharma companies will be able to maintain 24/7 communication with healthcare professionals to provide them customized educational materials. While learners experience barrier-free communication and support, pharma companies improve their businesses and product management. Since our preliminary version of the platform received high acceptance from end-users, we now aim to take the next step and scale up our model to hold a global community of users. Thus, the Feasibility Study planned in Phase 1 has the main objective of securing this project from all technical, commercial and financial perspectives. Altogether, our platform will bridge the existing gap between pharma providers and care givers, helping to relieve the huge impact incurred by the inadequate use of pharma products. In turn, DOCTRINA will provide us estimated cumulative revenues of €30 M after enrolling +650,000 users within five years from market launch

Keywords: digital health,information platform,health education,risk management,health ict,pharmacovigilance support,digital network
Laser-driven plasma sources of extreme ultraviolet light for nanolithography (EUVPLASMA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2024-01-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Moore’s law is not dead. Keeping it alive is of significant importance to society and to the economy. The prediction that the number of transistors in computer and memory chips doubles every two years, has pushed innovative, disruptive technologies, enabling the smartphone and driving tomorrow’s green automotive industries. It changes society. The density of elements realized on a chip is defined by one essential step in their production: lithography. Moore’s law thus provides a challenge to science and industry to develop beyond state of the art lithographic technologies. This challenge is being met by introducing extreme ultraviolet (EUV) lithography in high-volume manufacturing. This is happening right now. Generating the required EUV light – from tin-microdroplet-based laser-driven plasma sources – of sufficient power, reliability, and stability, presents a formidable, multi-faceted task, combining industrial innovations with attractive scientific questions. My proposal addresses this EUV source challenge through the following objectives: (1) create insight into tin-droplet deformation and fragmentation for optimal target preparation through laser-pulse impact, the first step of the two-step sequence used to produce EUV light; (2) provide understanding of the myriad of atomic plasma processes responsible for the emission of EUV light in the second step of the process; (3) understand and push the fundamental limit of this plasma-conversion of laser light into EUV light; and (4) explain and control how the laser-produced plasma expands. Each of these objectives has a significant potential impact in its own field of science and technology. This proposal as a whole has a further goal, namely to use the knowledge gained to transition from the CO2-laser technology currently in use for driving EUV sources to the superior, modern, solid-state lasers, to achieve the industrial dream of a plasma EUV light source that is one order of magnitude brighter.

Keywords: nanolithography
Accurate, Rapid, Robust and Economical diagnostic technoliogieS for Tuberculosis (ARREST-TB)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Italy,India,Spain,Spain,Italy,Russian Federation,United Kingdom
Call: Research on HIV, tuberculosis (TB) and/or hepatitis C (HCV) in patients with mono-, co-infections and/or comorbidities in the context of fostering collaboration with the Russian Federation (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2021-06-30
Duration (months): 30.0
Total project cost (EUR): 4438898.75
EU funding (EUR): 2997496.0
Participants: 9
Project status: CLOSED

This visionary project addresses the key needs of patients, clinicians and the World Health Organisations stated deliverables of affordable, reliable and point-of-care molecular TB diagnostics, with the vision of removing the need for centralised facilities and offering remote primary care diagnosis coupled with telemetry for “cloud based” notification to ensure public health and surveillance interventions. The core technology deliverables will include: Rapid screening of TB infection (within 30 mins): We will develop low-cost portable optical devices and chemical molecular probes for accurate and rapid ‘triage tests’ to allow ‘no-wash’ detection of Mycobacteria ‘in-field’ in sputum at costs comparable with or lower than existing microscopy-based methods. This technology has the aim of replacing current sputum-based microscopy methods. Rapid molecular identification of drug resistance (within 2 hours): We will develop novel low-cost assays based on molecular methods that will allow accurate and rapid screening for the Mycobacterium tuberculosis complex in sputum and drug-resistant tuberculosis, thus providing rapid screening of at risk groups for TB as well as identification of drug resistance profiles. Biomarkers for early diagnosis and assessing treatment response: A higher risk element is the development of point-of-care diagnostics for quantification of microRNAs (that are known to be modulated during progression from latent to active TB and during treatment progression), directly from small blood samples. We will ensure that the technologies are economically viable in the context of resource poor settings – indeed the whole project will be driven by practical need and local resourcing constraints – NOT imposition. Thus it will require negligible initial costs for implementation, minimal training and expertise, with the running costs less than 1/10 th of current detection technologies, thereby addressing a key objective of the work program.

Keywords: tuberculosis diagnostics,mycobacterium tuberculosis complex,mtbc,mycobacterium tuberculosis,multidrug resistant tuberculosis,mdr tb,triage tests,molecular method for tb,microrna
Role of cell lineage in the generation of neuronal diversity in the mouse cerebral cortex (NEURORIGINS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Cell lineage is an important determinant in the generation of neuronal diversity. Understanding the relation between cell lineage and neuronal identity is critical to know where and when cell fate decisions take place during development. In Drosophila, different neuronal types emerge from specific parts in the lineage tree. Some neuronal types specifically arise from certain branches (fate-restricted progenitor cells). Other neuronal types emerge from the same branch but at different times, following a temporal sequence. Whereas neuronal specification in mice seems to follow slightly different rules, the lack of appropriate tools to consistently target the same progenitor cells and following lineage progression with single-cell resolution has limited our understanding of this process. I thereby hypothesize that, similar to Drosophila, different neuronal types systematically emerge from dedicated parts of the lineage tree, although methodological limitations have impeded to prove this hypothesis. NEURORIGINS aims to fill this gap by producing tools to genetically target specific subsets of neuronal progenitors in the mouse cerebral cortex (Objective 1). To find fate-restricted neuronal progenitors and link these progenitors with specific types of projection neurons, I will use these tools to label and identify the neuronal progeny derived from these progenitor cells (Objective 2). In the last phase, I will follow the temporal progression of these sublineages, exploring whether some types of projection neurons are generated from the same sublineage over different developmental windows (Objective 3). Besides unveiling important insights on the developmental pathways resulting on neuronal diversity in the mouse brain, NEURORIGINS will provide me with a new set of technical and transferable skills that will be critical for my future as an independent researcher.

Keywords: cell lineage,neuronal diversity,genetic drivers,gal4 lines,neural stem cells,cerebral cortex,crispr,cas9,cassa,clades,gestalt,projection neurons,mice,cell specification,development
Dinuclear Gold Catalysis: A New Platform for Cross-Coupling Reactions (TWINGOLD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-03
End date: 2021-02-08
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Gold catalysis has become a powerful tool for organic chemists to streamline synthesis of valuable and complex molecules. Compared to other transition metals, gold complexes are remarkably stable towards air and water, and are essentially non-toxic, which make them ideal candidates to execute catalytic cross-coupling reactions in industry or in vivo. TWINGOLD aims at broadening the current applications of gold catalysis, exploring and identifying reliable dinuclear gold(I) catalysts in C-C forming reactions. The use of dinuclear gold catalysts could lower activation barriers of chemical transformations and thus allow access to reaction pathways that are difficult to accomplish with mononuclear gold systems. TWINGOLD will promote gold catalysis significantly by exploring novel cross-coupling reactions and the related mechanistic elements behind them, enabling use of more diverse raw materials and, thus, ensuring a more sustainable and inclusive economy in EU. In addition, the project will enable the Experienced Researcher to develop a full range of scientific and transferable skills following a personalized Career Development Plan to become an established researcher (R3).

Keywords: dinuclear gold,cross coupling,catalysis,alkylation,reaction mechanism
Establishing services Enhancing the innovation management capacity of SMEs in Bulgaria (EIIRCBG_H2020)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Bulgaria
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-07-01
End date: 2014-12-31
Duration (months): 6.0
Total project cost (EUR): 25156.25
EU funding (EUR): 20125.0
Participants: 5
Project status: CLOSED

The main objective of this project is to contribute to the implementation of the European policies in the field of innovation management capacity building in SMEs and their implementation in Bulgaria, resulting in effective and efficient investments in novelties leading to growth and quality jobs. As a major tool for improving global competitiveness of European companies, implementation of novelties in products, processes and society needs specially devoted attention and resources. This project will contribute to the better filtering and acceleration of innovation processes in Bulgarian SMEs, thus supporting growth and jobs. Supported companies are supposed to be better prepared for using Access to Finance instruments and attract investments in innovations

Keywords: h2020,innovation management
G-quadruplex DNA Structures and Genome Stability (G4DSB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany,Germany,Netherlands
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-07-01
End date: 2021-08-31
Duration (months): 74.0
Total project cost (EUR): 1531625.0
EU funding (EUR): 1119382.12
Participants: 3
Project status: CLOSED

Secondary structures such as G-quadruplexes (G4s) can form within DNA or RNA. They pose a dramatic risk for genome stability, because due to their stability they can block DNA replication and this could lead to DNA breaks. In certain cancer cells mutations/deletions are observed at G4s, if a helicase that is important for G4 unwinding is mutated. Nevertheless, G4s are also discussed to be functional elements for cellular processes such as telomere protection, transcription, replication, and meiosis. The aim of this research proposal is to use various biochemical and computational tools to determine which proteins are essential for formation and regulation of G4s. Proposed experiments will gain insights into both “effects” of G4s, the risk for genome stability and its significant function for the cell. In aim 1 we will elucidate and identify novel proteins that bind, regulate, and repair G4s, especially in the absence of helicases, in vitro and in vivo. Our focus is to understand how G4s become mutated in the absence of helicases, which proteins are involved, and how genome stability is preserved. In aim 2, we will use cutting edge techniques to identify regions that form G4s in vivo. Although there is experimental proof for G4s in vivo, this is not commonly accepted, yet. We will provide solid data that will support the existence of G4s in vivo. Furthermore, we will survey genome-wide when and why G4s become a risk for genome stability. Aim 3 will focus on the in silico observation that G4 structures are connected to meiosis. In this aim we will use a combination of techniques to unravel the biological significance of G4s during meiosis in vivo. Due to the connection of G4s and cancer the data obtained from this research proposal will not only be important to understand G4 regulation and formation, but will also provide unique knowledge on the impact of G4 structures for genome stability and thereby for human health.

Keywords: genome stability,s cerevisiae,secondary dna structures,double strand breaks,repair
The origin of heavy elements: a nuclear physics and astrophysics challenge (EUROPIUM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2021-10-31
Duration (months): 66.0
Total project cost (EUR): 1446875.0
EU funding (EUR): 1446875.0
Participants: 1
Project status: CLOSED

Where in the universe are heavy elements synthesized? How are these elements produced? These are two exciting and interdisciplinary questions in nuclear astrophysics today and will be investigated in my ERC project EUROPIUM. The favored astrophysical sites are neutrino-driven winds following core-collapse supernovae and neutron star mergers, where extreme conditions enable the rapid neutron capture process (r-process). We will perform long-time multidimensional simulations of these two scenarios and combine them with nucleosynthesis calculations. In neutron star mergers, the radioactive decay of neutron-rich nuclei triggers an electromagnetic signal known as kilonova. This was potentially observed in 2013 after a short gamma ray burst, associated with a neutron star merger. We will simulate the neutrino- and viscous-driven ejecta from the disk that forms after the merger around the central compact object. In addition, we will investigate supernova neutrino-driven winds that produce lighter heavy elements from strontium to silver. We will explore the impact of rotation, improved microphysics, and magnetic fields on the wind evolution and nucleosynthesis. Because the synthesis of lighter heavy elements elements occurs closer to stability, the nuclear physics uncertainties will be reduced by experiments in the near future. This will uniquely allow us to combine observations and nucleosynthesis calculations to constrain the astrophysical conditions and gain new insights into core-collapse supernovae. In nuclear physics, a new era for extreme neutron-rich isotopes is starting with new experimental facilities. Based on our simulations, we will study the impact of the nuclear physics input (nuclear masses, beta decays, neutron captures, and fission) going beyond the state-of-the-art by providing r-process abundances with uncertainties. Comparing our results with forefront observations of the oldest stars will in turn provide new insights about the origin of heavy elements.
Enhancing and implementing Knowledge based ICT solutions within high Risk and Uncertain Conditions for Agriculture Production Systems (RUC-APS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain,Argentina,Italy,Italy,China,Poland,France,France,France,United Kingdom,United Kingdom,United Kingdom,Chile,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-10-03
End date: 2022-04-02
Duration (months): 66.0
Total project cost (EUR): 1413000.0
EU funding (EUR): 1332000.0
Participants: 21
Project status: CLOSED

Increasingly challenging global and environmental requirements have resulted in agricultural systems coming under increasing pressure to enhance their resilience capabilities in order to respond to the abrupt changes in resource quality, quantity and availability, especially during unexpected environmental circumstances, such as uncertain weather, pests and diseases, volatile market conditions and commodity prices. Therefore, integrated solutions are necessary to support the whole food agricultural life-cycle value chain. Solutions necessarily must consider the products’ cycle, as well as each of the value chain stages. Thus, managing risks and the uncertain availability of information will lead farmers to take advantage of these managerial, technical and social based-solutions. This implies the need for innovative technology-based knowledge management system to capture the agricultural information, at a variety of regional locations, in terms of collecting, storing, processing, and disseminating information about uncertain environmental conditions that affect agricultural decision-making production systems. Hence, from the genetic design of the seed, till their planting and harvest processes, RUCAPS provides knowledge of the full agricultural life-cycle based-decision making process to realise the key impacts of every stage of the agriculture-related processes. Therefore, RUCAPS implies the development of a high impact research project in order to integrate real-life based agriculture requirements, alternative land management scenarios, unexpected weather and environmental conditions as well as supporting innovation in the development of agriculture production systems, operations, logistics and supply chain management and the impact of these systems and processes over the end-users and customers. This is to be conceived through the integration of standard and customised solutions for facilitating the collaborative engagement within the agriculture value chain.

Keywords: agriculture,horticulture,value chain,uncertainty,decision making process,modelingandsimulacion,global weather change,innovation