Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding pathogen, livestock, environment interactions involving bluetongue virus (PALE-Blu)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Italy,Israel,Türkiye,Belgium,Tunisia,Sweden,France,France,Netherlands,United Kingdom,Morocco,United Kingdom,Kenya,Senegal,United Kingdom,United Kingdom
Call: Understanding host-pathogen-environment interactions (H2020-SFS-2016-2, 2016)
Start date: 2017-06-01
End date: 2021-11-30
Duration (months): 54.0
Total project cost (EUR): 6039301.5
EU funding (EUR): 6039301.5
Participants: 21
Project status: CLOSED

New outbreaks caused by bluetongue viruses (BTVs) have emerged in European livestock every year since 1998. These events that have been linked to climate change, resulted in massive losses due to fatalities, reduced productivity, reproductive failures, restricted animal movements/trade, and surveillance/vaccination costs. PALE-Blu brings together European institutes with expertise in BTV research and diagnosis, with partners in endemic regions (Africa, the Middle East and Turkey) that act as a ‘source’ for BTV strains that emerge in Europe. Full-genome sequence-analyses will increase the accuracy of BTV-strain distribution maps, to identify pathways and mechanisms for spread into and within Europe, as well as appropriate prevention strategies. PALE-Blu will analyse the genetic connectivity of Culicoides vector populations in different regions, as well as the movements of individual BTV lineages and genes. Together with reverse genetics technologies and infection/replication studies in new Culicoides cell lines, or adults from different Culicoides species, this will elucidate the genetic basis for geographic localisation/movement of BTV strains and serotypes. We will analyse differences in saliva proteins from Culicoides species, their ability to modify the BTV surface proteins (proteases) and effects on efficiency of transmission (in both directions) between vertebrae hosts and insect-vectors. These studies will provide a better understanding of incursion risks for different BTV strains, supporting effective control strategies. PALE-BLU will explore more effective and cross-serotype subunit-vaccines that are DIVA assay compatible and generate a stronger immune response from a single innoculation. We will also explore the potential for use of antiviral agents to induce immediate protection post vaccination. More effective diagnostic systems to better detect mixed infections will also be developed by multiplexing existing or novel diagnostic assay systems.

Keywords: bluetongue virus,culicoides vector,bluetongue epidemiology
Innovative Concrete Barriers for Forgiving Road Infrastructure (SAFER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Cyprus
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 163648.8
EU funding (EUR): 163648.8
Participants: 1
Project status: CLOSED

One of the top ten goals set by the White Paper on Transport is to reduce fatalities in road transport. The European Union is aiming to halve road casualties by 2020, in line with the long term goal to move close to zero fatalities by 2050. Despite the reduction in road fatalities in the EU since 2010, there are specific countries where the numbers are increasing. In addition, the yearly decrease rate in road fatalities for Europe as a whole is slowing down. In order to reach the goal set for 2020, action should be taken immediately. The most vulnerable road users are motorcyclists, who are currently suffering from frequent fatalities in crashes involving road barriers. The European Road Assessment has indicated the critical need to adopt improved barrier designs to protect vulnerable road users. While rubberized concrete has been recommended for road barriers, challenges involving strength and durability of the material have not been addressed. This research proposes to develop optimised steel fibre-reinforced rubberised concrete mixtures as well as road barrier designs, which will lead to the development of SAFER road barriers with outstanding deformability and structural integrity; thus paving the way for forgiving road infrastructure. The use of recycled rubber and steel wires (obtained from End-of-life tyres) supports the Horizon 2020 Transport Research and Innovation Act priorities for sustainability and resource efficiency (including the Circular Economy package).

Keywords: concrete engineering,road barriers,end of life tyre recycling,experimental mechanics
Deciphering the cholinergic modulation of the hippocampal place code. (HippAchoMod)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Hungary,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-08-08
End date: 2020-02-07
Duration (months): 36.0
Total project cost (EUR): 245250.0
EU funding (EUR): 245250.0
Participants: 2
Project status: CLOSED

Acetylcholine released by cholinergic neurons in the basal forebrain is a critical component of the modulatory cocktail governing the emergence, stabilization and reorganization of cortical ensembles of co-active neurons representing the environment. In the hippocampus, ACh renders the state of the network optimal for the acquisition of novel information. Deterioration of cholinergic modulation leads to severe deficits in hippocampal function manifested as debilitating cognitive impairments. Despite decades of intense research fundamental questions are still open about the cholinergic modulation of hippocampal information processing: i) how is the behaviour-dependent firing of different neuron types determined by ACh? ii) how does ACh contribute to the emergence of the spatially selective firing of principal cells, their amalgamation into sequences representing the surroundings of the animal and the storage of “relevant” sequences? iii) how does ACh alter the place code in response to salient environmental stimuli? Technological breakthroughs of the past years have opened the possibilities of addressing these long-standing questions about cholinergic modulation. Thus, I aim to combine the latest electrophysiological recording, optogenetic manipulation and behavioural tracking methods to monitor hippocampal neuronal ensembles in freely behaving mice while manipulating the cholinergic input of the hippocampus by light-responsive microbial opsins. Results of the proposed research programme will decipher the role of ACh in hippocampal information processing and inform us how subcortical modulation contributes to the conversion of external inputs from the environment to internal representations. By accomplishing the programme outlined in the proposal I will be acquainted with the cutting edge technologies as well as skills indispensable for starting my independent research group and expanding the research potential of my home institute.

Keywords: neurogrid,silicone probes,optogenetics,subcortical modulation
PRO-S: The first highly energy efficient and eco-friendly bio based-photovoltaic module that works without sunlight or battery consumption for Smart buildings (PRO-S)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

With the ever-increasing demand for energy, the search for alternative energy sources has increased. Solar energy is by far the most abundant form of renewable energy and has the potential to partially replace fossil fuels, but its mass adoption is hindered by its weather dependency, the cost of their energy storage systems and certain environmental concerns. PRO-S® is the first flexible, semitransparent and toxic-free photonanobiotech module that uses conductive small organic molecules (proteins from bacteriorhodopsin cultivation) to produce electricity. It is an outperformer for our target markets since: 1) it is the first product capable of generating electricity and store it as hydrogen upon needs, obtaining higher efficiency in cloudy and sunny days compared to standard PV (60% and 16%, respectively); 2) it has low maintenance costs and environmental impact since no batteries are needed and is 60% recyclable; 3) it is a low cost energy source since the manufacturing is cheap (30% lower than standard PV) and independent from market fluctuations; and 4) it can be easily integrated and customized to any size. Being our first opaque PV module currently market for parking meter and table boards (eboard), our next goal is to fully develop and market a more complex and semitransparent PRO-S® module for its application as solar panel for buldings and glass windows. We will take advantage of our current partners and distributor network (from previous product eboard) to successfully deploy our improved product into the construction and building market. We plan to conduct a Feasibility Study to analyze the technical, commercial and financial viability of our advance product PRO-S® to ensure its market deployment and uptake. We estimate to reach a turnover of €38 Mio and to create a total of 25 direct jobs -and 500+ indirect jobs- in 2024, with an NPV of €8.2 Mio.

Keywords: photonanobiotech module,car windows,bipv,energy efficiency building
Boosting Ethionamide efficacy and lowering the dose with a small molecule transcriptional modulators, to overcoming MDR-TB infections and define a new place for Ethionamide in 1st-line TB treatments. (TRIC-TB)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Spain,Switzerland,France
Call: Functional Ethionamide boosters: a novel combination for tuberculosis therapy (H2020-JTI-IMI2-2018-16-single-stage, 2018)
Start date: 2019-05-01
End date: 2024-02-29
Duration (months): 58.0
Total project cost (EUR): 8373250.0
EU funding (EUR): 6926375.0
Participants: 3
Project status: SIGNED

Tuberculosis (TB) is the world’s leading infectious disease. It killed 1.7 million people in 2016 and 10.4 million people developed active TB in the same year. In 2016, 480’000 of TB cases were multidrug-resistant (MDR-TB) and 9% percent of those cases are extensively drug-resistant (XDR), with mortality rates as high as 70%. Ethionamide (ETH) is a vital part of the WHO essential medicines list of 2nd-line TB therapy for MDR-TB, however, ETH suffers from significant levels of resistance and side effects at current dosing levels. BVL-GSK038 and BVL-GSK098 are proprietary to BioVersys/GlaxoSmithKline and have been developed through an extensive Lead Optimization program with collaborators from Lille University. Low doses of both compounds fully restore and “boost” the activity of ETH to rapidly kill Mycobacterium tuberculosis (Mtb) including MDR strains at significantly lower doses of ETH than previously reported, thus making MDR-TB sensitive to ETH once again. Through a comprehensive IND enabling package including in vitro and in vivo assessment of ETH with BVL-GSK038 and BVL-GSK098, including PK/PD, resistance development, safety, mechanism of action and synergistic studies with different drug compound combinations and then first in human clinical studies the consortium aims to: i) Define the future placement of a boosted ETH (ETH + BVL-GSK038 or BVL-GSK098) in a universal TB treatment regimen, including overcoming MDR-TB with improved safety, time to cure and relapse rates; Ultimately, we expect to identify a new and clinically proven TB regimen that leads to better patient outcomes independently of the starting resistance status of the TB infection. The TB and wider scientific communities will benefit from an improved understanding of ETH and the exploration of a novel class of therapeutic compounds acting on transcriptional modulators (BVL-GSK038 and BVL-GSK098).

Keywords: tuberculosis treatment ethionamide boosting transcriptional regulator multi drug resistance amr clinical development phase ii better patient outcomes bioversys glaxosmithkline
Analysis of the role for coronin 1-dependent cell density signalling in T-cell homeostasis (COR1-TCELL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2021-03-02
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Harnessing T-cell homeostasis is important for cancer immunotherapy as well as anti-microbial immunity and the prevention of autoimmune disorders. T-cell homeostasis in peripheral lymphoid organs is known to be regulated through interleukin-7-mediated cytokine signalling and via T-cell receptors recognising self-peptides loaded on major histocompatibility complex. However, recent results suggest a requirement of a third pathway at low T-cell density such as in newborns that depends on the WD repeat protein family member coronin 1, the mechanism of which is unknown. The objective of this proposal is to elucidate the molecular mechanism of coronin 1-dependent sensing of low cell density that contributes to peripheral T-cell homeostasis. In preliminary work, I established a co-culture assay of T cells and antigen presenting cells that recapitulates coronin 1-dependent T-cell survival at low cell density. In addition, I found that adoptive transfer experiments reconstituted the coronin 1-dependent peripheral T-cell expansion in a lymphopenic environment in vivo. To delineate the molecular mechanisms underlying this cell density-dependent signalling mediated by coronin 1, I will combine the originally established in vitro and in vivo assay systems with state-of-the-art single-cell RNA sequencing, in addition to biochemical analysis utilising mass spectrometry. This will identify the signalling pathways and the molecules involved in this density-sensing mechanism. Finally, ad-hoc ablation of coronin 1 using a newly established inducible knockout mouse will reveal the role for coronin 1 in the maintenance of peripheral T cells after successful expansion at post-neonatal stage. The results from this project will define a hitherto uncharacterized density-sensing pathway required for T-cell homeostasis. Furthermore, the fellowship will potentiate my career opportunities as it allows to explore cutting-edge biology and technologies in a highly stimulating research environment.

Keywords: t cell homeostasis,cell density,lymphopenia induced proliferation lip,co culture system,single cell rnaseq,inducible knockout
Direct measurements of key nuclear Reactions for the creation of Elements in Stars (DoRES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-06-01
End date: 2024-09-30
Duration (months): 100.0
Total project cost (EUR): 1495479.0
EU funding (EUR): 1495479.0
Participants: 1
Project status: SIGNED

The evolution of the universe has left an imprint in the form of the chemical elements. Understanding the cosmic origins of the elements remains a major challenge for science. The abundances of elements we see in our solar system, distant stars, meteorites, and in stellar explosions provide us with clues about how the elements came to be produced in a variety of different processes and stellar environments. To unravel these mysteries we need to understand the nuclear reactions producing and destroying the elements. New generation accelerator facilities and instrumentation are being developed in Europe which will enable many of these reactions to be measured directly for the first time, and with high precision. This offers the prospect of a major step forward in the field in the next few years. Many of the key reactions involve unstable nuclei, studied experimentally either by using radioactive beams or targets. These unstable nuclei play a critical role in high temperature stellar environments, most notably stellar explosions. Reactions can occur on the unstable nucleus before it has decayed thereby strongly altering the path of subsequent element synthesis. The proposal is sub-divided into 5 themes, concerning production of the heavy elements in neutron capture reactions, destruction of the cosmic gamma-ray emitter 26Al in core collapse supernovae, neutron source reactions in stars, the puzzle of high abundances of proton-rich heavy isotopes, and the origin of nature’s least abundant isotope 180mTa. Experiments will initially be performed using neutron beams from the upgraded n_TOF facility at CERN including the high flux EAR-2 beam line, and using radioactive beams from the upgraded HIE-ISOLDE facility at CERN. In the later phase of the proposal experiments will also be performed using the new ultra-high intensity neutron beam facility FRANZ at Frankfurt, and with radioactive beams injected into heavy ion storage rings to be installed at GSI and CERN.
Sustainable and Standalone Oxyhydrogen powered heat generator box (Enerbox)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2015-06-01
End date: 2015-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

INSEEF has worked for more than 100 clients in the farming and agriculture sector including pig, poultry and dairy farms of all sizes as well as mushroom growers among others, who have a high and uninterrupted energy need mainly for heating applications. Farms are often located in in remote rural areas, where electricity access can be difficult. Consequently, current biomass solutions that have not grid access operate with diesel generators, which can be costly to maintain (Minimum 250l/gasoil per /month plus maintenance costs, and rely on external diesel supplies that produce significant CO2 emissions (8,65 CO2/year versus 0,65 for Enerbox). As a result, a significant number of our clients have expressed interest in reliable, standalone and cost effective biomass energy generators. EU off grid rural agriculture and farms will be the primary market for Enerbox, targeting both new thermal energy installations as well as existing ones. Enerbox aim is to introduce a disruptive off-grid scalable solution to EU the biomass market, providing stable access to thermal energy supply, flatten input-costs and make the most of low value feedstock. It will be a competitive solution for (mostly) off-grid applications that require a reliable and clean source of thermal energy offering a low levelized cost of thermal energy. To reach this aim, Enerbox project integrates efficiently two complementary sources of renewable energy (PV and biomass)plus energy storage, to produce steady and reliable thermal energy, and with the inclusion of an H2 sub-system that incorporates an innovative process to enrich the thermal potential of the waste biomass energy by mixing it with auto-generated oxyhydrogen gas obtained from reverse electrolysis, all in a modular compact transportable solution.

Keywords: biomass,photovoltaic,electrolysis,renewable,integrated,battery,oxyhydrogen,brow gas,hydrogen,heat,standalone,off grid,electricity,waste,modular,scalable
NOVEL OVEN WITH AUTONOMOUS ACCURATE TEMPERATURE CONTROL, FOR HIGHER ENERGY EFFICIENCY AND SAVINGS (OVENZA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Current commercial pizza ovens have a low efficiency due to unchecked heat energy losses from poor temperature control. Poor temperature control also limits the functionality of these ovens. The ovens fail to meet the operational parameters needed to satisfy an emerging market of a new pizza called “Pinsa” made from dough with 80% water content. Hence pizza or Pinsa being prepared will be of low quality, either burnt or undercooked. Another pitfall of standard electrical ovens is their lack of inbuilt sensors for condition monitoring for better planned maintenance schedules. Wood fired ovens on the other hand are complex, and have high CO2 emissions. The European Union (EU) has pledged to cut its energy consumption by 20% by 2020. To align with EU goals, pizzerias need an increase in efficiency and productivity of their ovens to be able to match peak periods of pizza demands while retaining pizza quality and minimising energy losses. The emergence of Pinsa, a game changer in the pizza industry, also calls for a multipurpose oven for both ordinary pizza and Pinsa with a good heat delivery system and accurate temperature control. Ovenza, our solution is a novel commercial pizza oven, which maximizes efficiency through accurate temperature control, focused heating, online condition monitoring and intuitive collaboration with users. Its distinguishing features are the central control unit (CCU), power modules (two of them), and the heat delivery system. The CCU controls the operation of power modules. Control parameters are based on user input (e.g. specific temperature, time) fed through the oven’s touch user interface or received remotely via Wi-Fi. The global pizza market, valued at €117Billion is forecasted to grow at a CAGR of 3.68% during the period 2016-2020. After 5 years of exploitation, we estimate to reach over €17.3M in sales and €5.2M in profits at a ROI of 3.16 and will create + 35 more jobs.

Keywords: pizza,commercial pizza oven,efficiency,central control unit,power module,low thermal inertia hob