Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Entanglement and Renormalisation for Quantum Fields (ERQUAF)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2023-01-31
Duration (months): 72.0
Total project cost (EUR): 1499375.0
EU funding (EUR): 1499375.0
Participants: 1
Project status: CLOSED

Over the past fifteen years, the paradigm of quantum entanglement has revolutionised the understanding of strongly correlated lattice systems. Entanglement and closely related concepts originating from quantum information theory are optimally suited for quantifying and characterising quantum correlations and have therefore proven instrumental for the classification of the exotic phases discovered in condensed quantum matter. One groundbreaking development originating from this research is a novel class of variational many body wave functions known as tensor network states. Their explicit local structure and unique entanglement features make them very flexible and extremely powerful both as a numerical simulation method and as a theoretical tool. The goal of this proposal is to lift this “entanglement methodology” into the realm of quantum field theory. In high energy physics, the widespread interest in entanglement has only been triggered recently due to the intriguing connections between entanglement and the structure of spacetime that arise in black hole physics and quantum gravity. During the past few years, direct continuum limits of various tensor network ansätze have been formulated. However, the application thereof is largely unexplored territory and holds promising potential. This proposal formulates several advancements and developments for the theoretical and computational study of continuous quantum systems, gauge theories and exotic quantum phases, but also for establishing the intricate relation between entanglement, renormalisation and geometry in the context of the holographic principle. Ultimately, these developments will radically alter the way in which to approach some of the most challenging questions in physics, ranging from the simulation of cold atom systems to non-equilibrium or high-density situations in quantum chromodynamics and the standard model.

Keywords: entanglement,renormalisation,tensor network states,quantum fields,holography
Coordination in constrained and natural distributed systems (CoCoNat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: CLOSED

In recent years, an algorithmic theory of natural and biological systems has been increasingly advocated as providing a much needed framework for investigating complex self-organising processes in nature. This project contributes to this research program by employing the distributed computing lens to model natural phenomena. Biological systems exhibit many properties also studied in distributed computing: they comprise several independently acting entities, tend to operate in noisy and dynamic environments, thus requiring them to be highly-resilient and adaptive, solve intricate coordination tasks, and display sophisticated communication techniques. This project aims to develop the theory of distributed synchronisation and coordination tasks in restricted models of distributed computing. These tasks are some of the most fundamental problems in distributed computing, as they are essential in computer networks as well as numerous other areas of engineering and computing. In addition, they are ubiquitous in natural and biological systems, ranging from molecular to population-level systems, which are known to solve various synchronisation and coordination tasks: examples include symmetry-breaking during the development of the nervous system, consensus decision making in species communities, and synchronisation in firefly populations and embryonic development. Unlike computer networks, biological distributed systems have unique features: (1) the agents typically have limited computational abilities, (2) communication is unreliable and restricted, (3) the system has a dynamic spatial structure, and (4) the environment may be noisy. Currently, distributed computing models that consider all aspects simultaneously are lacking. The proposed research approaches this goal from multiple angles by developing new models and analysis methods for determining the limitations of synchronisation and related tasks in both strong and weak models of computing.

Keywords: distributed algorithms,clock synchronization,consensus
Exploiting the DNA damage response to induce degradation of proteins (ExploDProteins)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-06-01
End date: 2025-05-31
Duration (months): 60.0
Total project cost (EUR): 1940756.0
EU funding (EUR): 1940756.0
Participants: 1
Project status: SIGNED

Here I propose to use small molecules to degrade proteins specifically around sites of DNA damage by using the damage itself as a homing signal. The approach will create new ways to study DNA damage, but will also offer translational possibilities in cancer. Cancer cells are often acutely sensitive to DNA damage because they have one or more faulty DNA damage response (DDR) pathways – a feature that makes them highly dependent on their remaining DNA repair systems. We will pioneer two novel and related chemical approaches for selectively killing cancer cells by modulating DDR pathways with bifunctional DNA damaging molecules. We will do this by reprogramming E3 ligases. E3 ligases are modular multi-protein complexes that destabilize cellular proteins by catalysing the formation of polyubiquitin chains on its substrates, which serve as a signal for proteasomal degradation. A recent revolutionary advance in chemical biology is to use small molecules to reprogram the protein degradation specificity of E3 ligases. By degrading proteins instead of inhibiting them, these small molecules achieve levels of functional modulation typically only possible with genetic techniques. We are inspired by this new protein degradation technology, but will take it in a new direction. Chemical damage of DNA recruits E3 ligases as well as critical DDR proteins in preparation for DNA repair. We will invent a new generation of small molecule protein degradation catalysts by repurposing these natural responses to DNA damage. We will accomplish our goal with three aims: Aim 1: Use DNA damage as a homing signal for induced protein degradation Aim 2: Use direct repair of DNA damage by the repair protein MGMT to promote the degradation of other proteins Aim 3: Promote pleiotropic protein degradation by recruiting broadly acting E3 ligases to sites of DNA damage I propose an ambitious project that will create conceptually novel ways to study the DDR and potentially build new medicines.

Keywords: induced protein degradation,dna damage,ubiquitin proteasome pathway,small molecules to reprogram biology
Superfluidity: a super-fluid, cloud-native, converged edge system (SUPERFLUIDITY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Germany,Israel,Germany,Spain,Ireland,Italy,Belgium,Romania,Greece,France,Netherlands,United Kingdom,United Kingdom,Portugal,Gibraltar
Call: Advanced 5G Network Infrastructure for the Future Internet (H2020-ICT-2014-2, 2014)
Start date: 2015-07-01
End date: 2018-03-31
Duration (months): 33.0
Total project cost (EUR): 7894615.0
EU funding (EUR): 7894614.0
Participants: 20
Project status: CLOSED

Superfluidity is “a state in which matter behaves like a fluid with zero viscosity”. Our project aims at achieving superfluidity in the network: the ability to instantiate services on-the-fly, run them anywhere in the network (core, aggregation, edge) and shift them transparently to different locations. The SUPERFLUIDITY project tackles crucial shortcomings in today’s networks: long provisioning times, with wasteful over-provisioning used to meet variable demand; reliance on rigid and cost-ineffective hardware devices; daunting complexity emerging from three forms of heterogeneity: heterogeneous traffic and sources; heterogeneous services and needs; and heterogeneous access technologies, with multi-vendor network components. The SUPERFLUIDITY solution is based on: a decomposition of network components and services into elementary and reusable primitives; a native, converged cloud-based architecture; the virtualization of radio and network processing tasks; platform-independent abstractions, permitting reuse of network functions across heterogeneous hardware platforms, while catering to the vendors’ need for closed platforms/implementations; and high performance software optimizations along with leveraging of hardware accelerators. As a result, the 5G network will benefit from: i) location-independence: network services deployable in heterogeneous networks; ii) time-independence: near instantaneous deployment and migration of services; iii) scale-independence: transparent service scalability; and iv) hardware-independence: development and deployment of services with high performance irrespective of the underlying hardware. Through these properties, SUPERFLUIDITY will provide a converged cloud-based 5G concept that will enable innovative use cases in the mobile edge, empower new business models, and reduce investment and operational costs. The SUPERFLUIDITY consortium gathers an impressive and uncommon blend of Telco and IT players that can make its vision a reality.

Keywords: convergence,heterogeneous traffic and sources,heterogeneous services and needs,heterogeneous access technologies,cloud,virtualised functionality,resource reuse and sharing
MALLEABLE SURGICAL RETRACTOR FOR COMPLETE EXPOSURE OF MITRAL VALVE (SALAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Spain
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Heart valves play a key role in the way blood flow, opening and closing with each heartbeat. Almost all interventions in cardiac surgery are performed to repair or replace the mitral, aortic or tricuspid valve. In specific case of mitral valve surgery, good exposure of mitral valve and its ring is essential for the surgeon Conventional mitral valve surgery is performed opening the sternum (20-25cm) with a retractor and then surgical operation is carried out. The use of minimally invasive (MIS) surgery allows decrease of recovery time, decrease of surgical trauma, reduction of pain improving patient satisfaction and reducing hospital resource utilization. All this advantages, make that nowadays half of mitral surgery operations are made in developed countries following MIS techniques. Main drawback of MIS surgery is that operation areas exposure is limited which makes surgeons work harder than doing it in open surgery. Better exposure translates into better surgical results, optimal stability of the surgery and optimal long-time clinical results. In Minimall invasive mitral surgery, only an anterior traction retractor is used but the exposure that allows to the surgeon is limited. Due to aging of population and development of emerging countries, mitral valve surgical procedures are growing market worldwide expecting to double its actual size for 2030. In this scenario, ANSABERE in collaboration with Dr. Anas Sarraj (surgeon of Hospital La Princesa in Madrid and associate professor of Autonomous University of Madrid) has developed an innovative device for both mitral conventional and MIS surgery, called SALAS, that provide better and complete exposition of the mitral valve and its ring from inside the left atrium. The instrument allows to surgeon to adjust and adapt the working area due to the use of the lateral flap and the malleability of the arms of the invention.

Keywords: device,mitral,valve,surgery,exposition,malleable,plasticity
European industrial doctorate for efficient multidisciplinary design Optimization of Multifunctional Aerospace Composite Structures (OptiMACS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Austria,Portugal,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-05-01
End date: 2022-10-31
Duration (months): 54.0
Total project cost (EUR): 1253230.03
EU funding (EUR): 1253230.03
Participants: 4
Project status: CLOSED

Modern aeronautical structures are increasingly made of composite materials due to their well-known benefits. Optimizing the design of aerospace composites vis-à-vis the entire range of operational constraints (i.e. reliability, stability, strength, weight, noise, manufacturability and cost) to which the aircraft structures are subject, results in a particularly challenging task for the structural designer. Despite the volume of recent work dedicated to new Multidisciplinary Design Optimization (MDO) models and techniques, the ‘No free lunch theorem in optimisation’ is constantly confirmed. A genuine need is therefore identified for a programme that will: i)Develop, deliver and implement novel and efficient structural MDO technological tools for the European aerospace industry, ii)Nurture and train the next European generation of MDO research professionals. OptiMACS has an intersectoral character, drawing know-how from both academic and industrial research and innovation teams. It also has an intensely multi-disciplinary character, coupling expertise from mechanical, aerospace, manufacturing and software engineering, as well as from the area of applied mathematics. On the research side, OptiMACS will focus on improving the accuracy and efficiency of the MDO platform currently employed by AIRBUS. This will be achieved by enhancing the design models and criteria related to composites failure and manufacturing, developing and implementing multiscale models for composites as well as investigating advanced MDO algorithms and architectures for enhancing efficiency. On the training side, OptiMACS will provide a fully supportive environment for 5 ESRs. A training programme aiming at developing both the research as well as the transferable skills of the Fellows has been designed. All Fellows will have the opportunity to work in a multi-disciplinary environment, spending at least 50% of their time at the premises of the industrial beneficiaries.

Keywords: multidisciplinary design optimization,industrial composite structures,multiscale modelling,efficient optimization architectures
Global scale-up of GoSleep Pods more than a seat (GoSleep)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-05-01
End date: 2021-02-28
Duration (months): 34.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1050000.0
Participants: 1
Project status: CLOSED

Patented breakthrough innovation is a combination of product and service; GoSleep Pods are fully automatic reclining seats with privacy shade already in use at 25 airports and other locations globally. Wide market understanding helps the optimizing of the products and during this project finalized V2 Pod will be launched. The potential for scaling the service to the new market segment is significant, the next focuses are offices, hospitals, roadside service stations are other terminals. GoSleep Pods are pioneering products on the market and have clearly more suitable features for the airport use than any of a few other competitors. GoSleep brand is already globally known and the brand value is high. Commercialization of GoSleep Pods creates new service market of 505 M€ and up to 3000 workplaces. Benefits include sleeping safety, health, satisfaction and working efficiency for the users. GoSleep Pods provide a solution for a clear user need: privacy during transit is asked by 1.4 billion air passengers globally. GoSleep Ltd. (founded 2011) has a team with enthusiasm and relevant know-how. GoSleep Ltd. has an excellent network of partners in both subcontracting and distribution. GoSleep Ltd. has a realistic target, 30 M€ turnover in 2011. The business strategy is well planned and the products are patented and trademark protected. The Horizon 2020 Instrument Phase 2 project is planned to speed up the global scale-up. The H2020 project will result to; market launch of the new V2 Pod and 60M€ turnover in the next four years, optimized and scaled-up production, optimized business models based on MRR+ thinking, thorough market understanding, scale-up activities and active communication with stakeholders and users.

Keywords: innovation,public transport,service market,industrial design,airports,coworking,terminals,travelling services,air passengers,sleep,rest,privacy,global potential
JULES HOROWITZ OPERATION PLAN 2040 (JHOP2040)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Research infrastructure
Action type: Coordination and support actions
Countries involved: Spain,Sweden,Belgium,Finland,France,Czechia,United Kingdom
Call: Roadmap for use of Euratom access rights to Jules Horowitz Reactor experimental capacity (NFRP-2019-2020, 2019)
Start date: 2020-09-01
End date: 2023-09-30
Duration (months): 37.0
Total project cost (EUR): 1572117.5
EU funding (EUR): 1100501.2
Participants: 10
Project status: SIGNED

Material Testing Reactors have been for many decades key research tools for fuel and material behaviour studies under neutron flux supporting nuclear industries, research institutes and regulators. Whatever the progress in simulation, MTRs will remain a necessity for the qualification of new fuels and materials under irradiation notably in support to safety demonstration. Currently, in response to this need, the Jules Horowitz Reactor (JHR) is under construction. The JHOP2040 proposal presents a Coordination and Support Action aiming to 1) bring together with the JHR consortium of key actors, all relevant European nuclear research associations and member states that are not represented in the JHR consortium and 2) to produce strategic research roadmaps for the operation of the JHR. These roadmaps will cover both the first 4-year programme period and the following 11 years of operation. The outcome of JHOP2040 will be financial and programme model for Euratom taking into account also the governance and cost breakdown of the programmes. JHOP2040 will strengthen and widen the JHR research network by bringing together relevant stakeholders and interest groups to identify and review their current and future needs for fuel, material and technology issues within and outside of the current JHR consortium. Extensive utilization of the JHR via Euratom access rights and full use of the planned JHR capacity by promoting and enhancing the collaboration between potential users is the ultimate goal. The main advantage of this proposal is that all European partners of the JHR consortium are behind the proposal and several EU member states outside the JHR consortium and European institutions have expressed already their interest in being involved in the roadmap work. Important part of the proposal will be the communication with EU member states via JRC. JHOP2040 will have a close connection to the NFRP-08 CSA in this same call.

Keywords: jules horowitz reactor,material testing reactor,innovative nuclear material and fuel,education and training,roadmap of irradiation experiments,euratom access rights,safety of existing and future npps
Dialogue About Radicalisation and Equality (DARE)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Malta,Belgium,Norway,Tunisia,Türkiye,Greece,Croatia,Poland,Russian Federation,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Contemporary radicalisation trends and their implications for Europe (H2020-SC6-REV-INEQUAL-2016, 2016)
Start date: 2017-05-01
End date: 2021-10-31
Duration (months): 54.0
Total project cost (EUR): 4999053.75
EU funding (EUR): 4999053.75
Participants: 18
Project status: CLOSED

DARE aims to significantly increase understanding of why and how young people become radicalised and our capacity to effectively counter radicalisation. It does this through integrating research, policy and practice objectives in a three stage process of: 1) critical review of existing knowledge, policy and interventions in radicalisation and counter-radicalisation; 2) generation of new empirical research on young people’s encounters with, and responses to, messages and agents of radicalisation; and 3) integration of research findings to develop, pilot and evaluate two educational toolkits and a de-radicalisation programme evaluation tool to enhance the effectiveness of counter-radicalisation interventions. Through its focus on Islamist and anti-Islam(ist) radicalisation DARE addresses both ‘religious fundamentalism’ and ‘violence and hate crime’ dimensions of the topic call and explores how radicalisation processes interact to produce cumulative effects. It takes as its focus young people as a group that is targeted by recruiters and conventionally understood to be receptive to radicalism. It also places emphasis on gender dimensions of radicalisation. DARE recognises that improving knowledge on radicalisation has urgent implications for societal security but contributes to the wider objectives of the ‘Reversing inequalities and promoting fairness’ call through recognising that social inequality and discrimination give rise to perceived injustice which may motivate engagement with radical ideologies and actions. DARE’s primary concern is to address the long term social roots and effects of radicalisation and to engage young people themselves in countering radicalisation through its, innovative, attention to non-radicalisation alongside radicalisation trajectories. The DARE Consortium brings together academic and civil society organisations to ensure integration of its academic, policy and practice elements and includes members from 9 EU and 4 non-EU countries.

Keywords: radicalisation,deradicalisation,counter radicalisation,youth,gender,islamist movements,anti islam ist movements,in equality,in justice