Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deep-learning models of CRISPR-engineered cells define a rulebook of cellular transdifferentiation (SingleCellAI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: CLOSED

Cellular identity is controlled by cell type specific expression of transcription factors (TFs), and it is reflected in the cell’s epigenetic landscape maintained by epigenetic regulator proteins (ERs). Functional dissection of cellular identity has focused mainly on a small number of lineage-defining master regulators, yet there is increasing evidence that multiple TFs and ERs work together to establish and retain the vast number of different cell types and cell states in the human body. For a more quantitative understanding of cellular identity, and of the complexities of its regulation, I propose to develop a machine-learning approach for in silico prediction of TF/ER cocktails that can transdifferentiate any human cell type into any other cell type, thus defining an operational rulebook of cellular transdifferentiation. To this end, I will train a machine-learning model called generative adversarial networks (GANs) on large-scale CRISPR single-cell sequencing (CROP-seq) datasets generated in the host lab. Exploiting unique features of the deep-learning generative approach, the resulting model will be able to generalize the learned genetic perturbations across cell types in silico. I will experimentally validate several of these predicted TF/ER transdifferentiation cocktails in the context of the human hematopoietic system. Importantly, the proposed approach is hypothesis-free and data-driven, exploiting recent advances in machine learning to infer fundamental aspects of the regulation of cellular identity from high-throughput functional CRISPR single-cell sequencing data.
Topotronic multi-dimensional spin Hall nano-oscillator networks (TOPSPIN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Sweden
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

TOPSPIN will focus on spin Hall nano-oscillators (SHNOs), which are nano-sized, ultra-tunable, and CMOS compatible spin wave based microwave oscillators. TOPSPIN will push the boundaries of SHNO lithography, frequency, speed, and power consumption by combining topological insulators, having record high spin Hall efficiencies, with materials having ultra-high spin wave frequencies. TOPSPIN will reduce the required current densities 1-2 orders of magnitude compared to state-of-the-art, making SHNO operating currents approach 1 uA, and increase the SHNO operating frequencies an order of magnitude to as high as 300 GHz. TOPSPIN will use mutually synchronized SHNOs to achieve orders of magnitude higher signal coherence and achieve novel functionality such as pattern matching and neuromorphic computing. TOPSPIN will demonstrate mutual synchronization of up to 1,000 SHNOs in chains, and as many as 1,000,000 SHNOs in very large-scale two-dimensional arrays. Using dipolar coupling between SHNOs fabricated on top of each other, three-dimensional mutual synchronization will also be demonstrated. As the signal coherence increases linearly with the number of mutually synchronized SHNOs the oscillator quality factor will improve by many orders of magnitude. TOPSPIN will also develop such arrays using magnetic tunnel junction stacks thus combining ultra-high coherence with the highest possible microwave output power. TOPSPIN will demonstrate ultrafast pattern matching and neuromorphic computing using its SHNO networks. It will functionalize SHNOs to exhibit ultra-fast individual voltage controlled tuning and non-volatile tuning of both the SHNO frequency and the inter-SHNO coupling. TOPSPIN will characterize its SHNOs using novel methods and techniques such as multichannel electrical measurements, time- and phase-resolved Brillouin Light Scattering microscopy, time-resolved Scanning Transmission X-ray Microscopy, and ultrafast pump-probe Transmission Electron Microscopy.

Keywords: microwave oscillators,oscillatory computing
RV001: An anti-metastatic cancer vaccine (RV001)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-04-01
End date: 2018-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Prostate cancer is the most commonly diagnosed cancer among men, with an anticipated 1.7M new cases and 499,000 deaths by 2030 worldwide. Although, most cancer therapies available focus on treatment of the primary tumor, the leading cause of cancer morbidity and mortality is metastasis. Today’s current treatments for metastatic prostate cancer focus on later stage of the cancer progression, when the signs of metastasis spread are already observed; and modestly prolong the patient’s survival and have serious side effects. Therefore, there is a high unmet need for new therapies, which can effectively address the problem as the first adjuvant treatment against early stage of metastasis in prostate cancer. RhoVac is a biotechnology company dedicated to the research and development of immunotherapies for the treatment of early stage metastatic cancer. The RV001 (RhoVac’s first product) vaccine is the first therapeutic vaccine against metastatic cancer cells, specifically targeting the prevention of cancer relapses. The concept behind RV001 relies on the reprogramming of the patient own T cells to recognise and eliminate early stage metastatic cancer cells. Together with an unprecedented therapeutic potential in multiple cancer types, RV001 holds important competitive advantages, such as safety, tolerability and cost-effectiveness. However, to secure swift development and successful commercialization, RhoVac needs partnerships and capital to achieve RV001 clinical validation. In this context, we believe SME instrument will be crucial to position RV001 within the metastatic cancer treatment and to confirm the high pharma-economic value of our disruptive technology. The accomplishment of SME Phase 1 and Phase 2 project objectives will maximize the clinical value of our vaccine within the selected market and a lead to a significant business opportunity for RhoVac – revenues are expected to be around €350M, within 5 years of market approval, only in prostate cancer segment.

Keywords: metastatic cancer,prostate cancer,immunotherapy,prophylactic vaccine
PeptiEUForce: a game-changing ingredient for the pre-diabetic population (PeptiEUForce)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Ireland
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-09-01
End date: 2023-01-31
Duration (months): 77.0
Total project cost (EUR): 3136007.75
EU funding (EUR): 2195205.42
Participants: 1
Project status: CLOSED

Diabetes is accepted as a global and EU epidemic, with 415 million people suffering type 2 diabetes worldwide. Europe has 60 ml. diabetics, swallowing 13% of the EU healthcare budget, or €290bn. This is before we add the 318 ml. people globally with impaired glucose tolerance (prediabetics). The EU has highlighted functional foods as a valuable solution to prevent diabetes but to date, no advances of any significance have been made in scientifically proven functional food solutions in the diabetes arena. Existing methods for discovering such solutions are ancient and are exceedingly time, resource, and cost heavy. Nuritas Founder, Dr Nora Khaldi disrupts the paradigm using artificial intelligence and DNA analysis to find new disease-beating molecules in natural foodstuffs. She pioneers the field of food bioinformatics where she has won multiple EU competitive grants in her 11-year long academic research career. Recognised as having the potential to grow bigger than Facebook in size, Nuritas boasts the world’s largest peptide database, which along with a unique discovery method has helped find a groundbreaking, scientifically validated and patent-filed peptide molecule. This regulates blood sugar, which is key in the battle with diabetes type 2. Together with the exclusivity of our 20-year patent protection, it will deliver a very significant and on-going partnership with a food/pharma multinational company. Nuritas is expected to generate significant global sales by 2024 with a resultant high delivery on job creation through the development of this peptide. The significant learnings from this project will also be utilised on Nuritas’ consistently expanding portfolio of other novel life-changing molecules. The European and global socio economic impact will be huge. This is both in terms of longer, better lives and substantial savings delivered for overstretched healthcare budgets already groaning under the ever increasing epidemic of diabetes.

Keywords: diabetes,peptides,functional food,clinical trials,efsa claim,artifical intelligence,bioinformatics
Investigating the role of the inner retina in age-related macular degeneration (AMD) (Retina Rhythm)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Ireland
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-07-01
End date: 2025-06-30
Duration (months): 60.0
Total project cost (EUR): 1999455.0
EU funding (EUR): 1999455.0
Participants: 1
Project status: SIGNED

Age-related macular degeneration (AMD) is the leading cause of irreversible central blindness in the world. The number of people with AMD is predicted to be 196 million by 2020, with an estimated 1 in 10 people over the age of 55 already showing early signs of the condition. Identifying those individuals at greater risk of disease progression is challenging and robust animal models of disease are delaying the development of therapeutics. We have recently discovered that the blood vessels of the inner retina are highly dynamic and our data suggest that they play a central role in AMD development. I hypothesize, in contrast to studies to date, that the inner retina may be critical to the early stages of AMD onset. We have discovered that circadian regulation of the inner blood-retina barrier (iBRB) allows for replenishment and renewal of components of photoreceptor outer segments on a daily basis by a process we have termed Retinal Interstitial Kinesis (RIK). Here, I propose that circadian mediated regulation of the inner retinal blood vessels is paramount in the early stages of AMD pathology. Our preliminary data suggests that circadian-mediated changes in the permeability of the iBRB can lead to an AMD-like phenotype in mice and non-human primates. I propose that re-establishing the dynamic cycling of the iBRB may represent a novel therapeutic strategy for the prevention and treatment of AMD. Over the next 5 years, the central aims of Retina-Rhythm are to: 1. Develop and characterize newly established mouse and non-human primate models of AMD by disrupting circadian cycling of the iBRB. 2. Develop a novel AAV based vector with the ability to re-establish dynamic circadian cycling of the iBRB and treat AMD. 3. Prove that dysregulated circadian-mediated iBRB cycling mediates AMD pathology in human subjects. Our goal: To determine the key early initiators of AMD and to develop the next generation of therapies for this devastating form of blindne

Keywords: age related macular degeneration amd,blood retina barrier brb,tight junction
European Researchers' Night: The Night Deal (The Night Deal)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Cyprus
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-06-09
End date: 2021-04-08
Duration (months): 10.0
Total project cost (EUR): 143750.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The Night Deal proposal aims at organising a European Researchers' Night (ERN) event in Nicosia. The proposal's overall objective is to reach out to the wider public and raise awareness about the research and innovation (R&I) activities undertaken at national and EU level while boosting knowledge about the benefits of science to society in order to stimulate the interest in research careers, especially among young people and their families. The Night Deal aims also at promotimg the agenda of the European Green Deal initiative for a greener and smarter world, for a more sustainable future through R&I. The Coordinator, the Research and Innovation Foundation (RIF), as the National Agency for supporting R&I, has within its remit gained a long experience in organising activities for the promotion of R&I towards the public and especially the younger generation, with the ERN events being an integral part of its philosophy since 2006, and always with the vivid support from the National R&I System. The proposed event will be the result of a long-lasting and well established collaboration of the RIF with all relevant R&I stakeholders (government, industry, academia) and participants from the public ensuring maximum complementarity. Building on past experiences, The Night Deal will bring together researchers from all sectors and disciplines, along with the public, increasing appreciation of the researchers’ work, raising awareness on the importance of R&I for society and the economy and motivating young people to take up a career in research. With the motto 'science for all' as a flagship and through pre-events, side and main event consisting of a balanced mix of edutainment and inreactive activities aiming at people of all ages, genders and educational backgrounds, The Night Deal will celebrate R&I achievements, especially EU funded and will ultimately remove stereotypes about the researchers’ profession, creating a much needed R&I culture among the Cypriot society.

Keywords: european researchers night,science communication,research career,science for all
The illumination revolution (Pipelight_2)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: France
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-12-01
End date: 2023-05-31
Duration (months): 30.0
Total project cost (EUR): 2475000.0
EU funding (EUR): 1731625.0
Participants: 1
Project status: SIGNED

Light is what powers the world and makes our cities live. Light is identified as civilization’s first marker of development. In our lives, light is everywhere, produced by the Sun or artificially created by human ingenuity. However today’s lighting technology is contributing to global warming, therefore threatening both our planet and its inhabitants, contributing to the depletion of natural resources and the loss of biodiversity. Ironically Nature has done 3.8 billion years of research and development through evolution to find the most efficient solution in terms of lighting: bioluminescence. Fireflies, glow-worms, and more than 80% of marine organisms (jellyfish, plankton, fish, squids, sharks, krill) produce this biological light without needing the Sun. Glowee has decided to imitate what Nature does best and use these super-powers to develop biological lighting. For 5 years, Glowee’s multidisciplinary team (biologist, designer, business, finance) have been working to create the bedrock of Pipelight_2, a living system producing continuous bioluminescence in order to replace urban artificial lighting, reduce environmental impact, improve well-being and offer new creative possibilities. Glowee has acquired unparalleled, world-leading expertise in the field of bioluminescence, recognized globally by more than 20 innovation awards and 3 patents filed. Global smart lighting market fitting with Glowee’s technology is huge (> 1b€) and our business plan reach 28 M€ of revenue in 2028. TRL6 has been reached, the market validated through over 50 stakeholder interviews. The proposed project aims to increase the product performances to be ready for most challenging and impactful outdoor use (intensity, temperature resilience, cost-efficiency) and run a first pilot market demonstration (grant request). With the equity request, Glowee is willing to partner with a patient investor supporting its unique technology and its ambition to lead the light industry revolution.

Keywords: smart cities,biomimicry,biosourced material
Quantification and modality in the realm of questions (QuModQu)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2021-08-31
Duration (months): 60.0
Total project cost (EUR): 1391324.0
EU funding (EUR): 1391324.0
Participants: 1
Project status: CLOSED

The interpretation of linguistic expressions has been investigated from various theoretical perspectives, ranging from linguistics and philosophy to logic and cognitive science, leading to many applications in computer science. At the heart of this enterprise is a simple yet powerful notion of meaning as truth-conditional content. Despite its merits, this view has a fundamental limitation: while suitable for statements, it does not apply to other sentence types, like questions. This limitation has recently led the applicant and his collaborators to propose a more general notion of meaning, giving rise to a new semantic framework called inquisitive semantics. This framework opens up new horizons for all disciplines concerned with linguistic meaning. The present project explores these horizons in logic and linguistics, also making substantial connections with philosophy and computer science. In linguistics, besides providing a framework for the analysis of questions, the new approach suggests that inquisitive content plays a role in the semantics of statements as well, which sheds new light on recent linguistic observations that are highly puzzling from a purely truth-conditional point of view. In logic, the enriched notion of meaning also opens up new, exciting possibilities. While logic is standardly concerned with reasoning processes that involve concrete pieces of information, our new perspective also allows us to consider reasoning processes involving types of information. Relations between types of information play a central role in natural sciences, and also in various applicative domains in computer science. The project will explore in detail how the inquisitive perspective extends the boundaries of logic and linguistics, with a particular focus on the domains of quantification and modality, which are central to both enterprises. The approach will be highly inter-disciplinary in nature, forging cross-fertilization between the two fields.

Keywords: philosophical logic,modal logic,logic of questions,formal semantics,inquisitive semantics,dependence logic
European Researchers' Night in Bosnia and Herzegovina 2016-2017 (RiNG-16-17)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy,Bosnia and Herzegovina
Call: European Researchers' Night (H2020-MSCA-NIGHT-2016, 2016)
Start date: 2016-06-01
End date: 2017-11-30
Duration (months): 18.0
Total project cost (EUR): 193650.0
EU funding (EUR): 153780.0
Participants: 4
Project status: CLOSED

European Researchers' Night in Bosnia and Herzegovina 2016-2017 (RiNG-16-17) will jointly represent research and innovation landscape from Republika Srpska and Federation of BiH, promote scientific careers and enhance public recognition of researchers' work with the message "Researchers are amongst us" by engaging interactive communication with the public at large in whole BiH. RiNG-16-17 slogan is “research and innovation – two sides of the same coin”. The event is based on “discovery of unknown” and “building better tomorrow” concepts, and will be organized in collaboration with 2-days StartupDNA conference. RiNG-16-17 is a Researchers’ Night of national character, involving coordinated actions in six cities in Bosnia and Herzegovina, and incorporates cross-border aspect by involving researchers and research-driven business from the Balkan region as participants in RiNG activities. Promotion campaign will largely rely on European dimension and will be coordinated with other Researchers' Nights in EU and Western Balkan region. Specific activities will be organized in several cities in BiH, thus becoming "national" research promotion event in this country: - Edutainment parks with hands-on experiments, directly engaging general public into communication with researchers; - High school competitions for the best science projects; - Science coffee and talks to scientists, labeled as "RiNG.ME"; - Various competitions, games and quizzes, especially directed to younger audience; - "Stand Up Science" lectures, presentations; - Large EU area: EU corners with policy and gender issues advisory, as well exhibition of EU-funded projects in BiH; - Thematic activities at supporting universities, research centres and museums; - Science Movie Night and Science Party. RiNG-16-17 quantitative targets per event/year are: - Number of people to be reached through awareness raising campaign in BiH: 350.000; - Expected number of direct attendees to organized events in whole BiH: 15.000.

Keywords: edutainment,communication,science communication,public recognition of researchers,promotion of science careers,researchers night