Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Small Molecule Activation by Main-Group Compounds (SMAC-MC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Finland
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-07-01
End date: 2023-12-31
Duration (months): 66.0
Total project cost (EUR): 1424190.0
EU funding (EUR): 1424190.0
Participants: 1
Project status: SIGNED

Many basic chemical processes involve the activation of small unreactive molecules, such as hydrogen, nitrogen, ammonia, water and carbon dioxide, by transition-metal-based catalysts or by enzymes. This proposal focusses on the interesting and recently observed possibility to perform similar transformations with main-group compounds that consist entirely of cheap earth-abundant elements. The proposed research is split into four work packages of which the first investigates the mechanisms by which different main-group singlet diradicaloids activate small molecules and how their reactivity correlates with their radical character. The second work package focusses on small molecule activation using main-group metalloid clusters, a new emerging field that we have recently pioneered, and compares the reactivity determined for main-group species with that known for related transition-metal clusters. Investigations in the third work package concentrate on the electrochemical reduction of carbon dioxide and on the possibility to lower the required overpotential with frustrated Lewis pairs that readily form adducts with small molecules. The fourth work package revolves around activating small molecules by diborenes and, in particular, observing novel reactivity in situ, that is, before the reactive diborene is trapped with a suitable Lewis base. Considered as a whole, the planned initiatives will enable significant breakthroughs in the design of novel main-group element based compounds for the activation of small molecules. The research is not only of fundamental scientific importance but also of potential practical value as many main-group systems, such as frustrated Lewis pairs, are currently being examined as novel catalysts. An ERC consolidator grant would significantly strengthen my position in this interesting subfield of inorganic chemistry and give my research group practical means to continue performing cutting-edge research.

Keywords: inorganic chemistry,main group chemistry,computational chemisty,experimental synthesis,small molecule activation,diradicaloids,metalloid clusters,electron precise boron compounds
Laser surface engineering for new and enhanced functional performance with digitally enabled knowledge base (SHARK)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Germany,Spain,Switzerland,Sweden,France,United Kingdom,United Kingdom,United Kingdom
Call: New product functionalities through advanced surface manufacturing processes for mass production (H2020-FOF-2017, 2017)
Start date: 2017-10-01
End date: 2021-03-31
Duration (months): 42.0
Total project cost (EUR): 4434352.5
EU funding (EUR): 4434352.5
Participants: 12
Project status: CLOSED

SHARK will unlock the potential for laser texturing for the generation of functional surfaces by boosting the productivity, efficiency and flexibility of the process. This will provide the European industry with a highly robust, cost effective and environmentally friendly system that is capable of producing a broad range of functional surfaces at industrial scale throughputs, and place Europe in an unassailable lead in this key area of manufacturing. SHARK will advance laser surface texturing from the current ‘trial and error’, lab-scale concept into a highly predictable, data driven industrial approach by developing a digitally enabled knowledge management platform with a comprehensive database of process parameters and functionalities. SHARK system will be configured as an Open-platform independent of the laser source manufacturers, which for long, has been one of the main limitations for the process. SHARK’s system will be underpinned by a number of technology advances. Two laser surface texturing technologies will be developed, both based upon nanosecond fibre lasers. Pseudo Random laser texturing and Direct Laser Interference Patterning will be employed, offering complementary techniques to yield a highly flexible tool capable of delivering wide range of functional surfaces with exceptional productivity and excellent process efficiency. The project will develop surface texture predictive modelling to rapidly define key process variables required for specific surface functionalities. This will be combined with inline surface characterisation to enable rapid feedback and inbuilt quality assurance. The project will deliver the following benefits: • The capability to deliver surface functionalities into real products for less than 10% of the cost of the conventional part • Greater than 20% improvement in product performance based on the surface functionalities deployed. • Accelerated product development • Strengthened global position of European manufacturing

Keywords: laser surface texturing,knowledge management system,in process inspection,predictive modeling,anti bacteria surfaces,anti icing surfaces,high friction surfaces
Multilevel Modelling for Predictive Toxicology (COMPTOX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: European organisations area
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-07-01
End date: 2011-06-30
Duration (months): 12.0
Total project cost (EUR): 114337.52
EU funding (EUR): 114337.52
Participants: 1
Project status: CLOSED

Computational toxicology seeks to apply modern computing and information technology, with molecular biology and chemistry to predict toxicity of chemical compounds and to improve risk assessment. Recent technological breakthroughs have made it possible to discover new mechanisms of toxic action and have opened the way for the implementation of systems biology and in silico methods in the field of toxicology. Coupling different levels of modelling will enable the integration of disparate data and will provide a powerful tool for studying various aspects of predictive toxicology.

Keywords: computer modeling,systems biology,computational toxicology
Non Extensive Thermodynamics and Statistical Mechanics in Earthquake Physics & rock fracture (NEXT EARTH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-07-01
End date: 2011-06-30
Duration (months): 24.0
Total project cost (EUR): 246983.34
EU funding (EUR): 246983.34
Participants: 1
Project status: CLOSED

Understanding of earthquake physics will enhance the quality of life both of European citizens and of vulnerable populations worldwide. In NEXT EARTH proposal will reanalyze and generate unique, well constrained, laboratory data on acoustic emissions (AE) and pressure stimulated currents (PSC) under simulated in-situ conditions (stress-temperature) and will develop new innovative techniques based on modern thermodynamic and non extensive statistical physics [NESP] principles for both the analysis of laboratory and seismicity. The objectives of the proposal are the study of: a) scaling and universality in rock fracture and earthquake physics, b) NESPs’ applicability in fracture (i.e., in AE and PSC) and earthquake physics and c) the universal behaviour of seismicity, AE, and PSC/ SP in natural time domain [NTD}. The objectives will progressed along two parallel and interlinked avenues: Experimental Part. To understand better the mechanisms that produce AE and PSC at in-situ conditions similar with that up to a few kilometres depth within the crust, the state-of-the-art triaxial cell at UCL will be used to impose a deviatoric stress regime upon rock samples, Theoretical Part: from fracture to earthquake physics. To analyse AE and PSCs prior to failure the model of Motion of Charged edge Dislocations will be used. NTD and NESP will applied in AE, PSC and seismicity. NTD enables a universality in dynamical evolution of complex systems and identifies the systems’ enters at critical stage, while NESP offers a consistent theoretical framework to analyze earthquake/fracture systems where fractality, long range interactions, intermittency are important. In NEXT EARTH, for the first time will measure simultaneously AE/PSC under in-situ triaxial conditions as in seismogenic zones and will integrate the interpretation of AE and PSC along with seismicity within a totally new innovative framework of ideas vastly improving the state-of-the-art in rock and earthquake physics.

Keywords: earthquake physics,rock fracture,non extensive thermodynamics,statistical mechanics,entropy,seismicity,scaling laws
Equivariant topology in algebraic geometry (EQUITOP IN ALGGEO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Hungary
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-07-01
End date: 2010-06-30
Duration (months): 12.0
Total project cost (EUR): 78532.63
EU funding (EUR): 78532.63
Participants: 1
Project status: CLOSED

In physical sciences, a very challenging problem is the understanding of sudden changes caused by smooth alterations of parameters. For instance, water suddenly boils, or ice melts. The back of the camel breaks suddenly under a load of just one more straw. These abrupt changes are not only present in dynamical systems, but also in biology (e.g. population models, cell growth), and human society (e.g. stock markets). The proposer studies the mathematical theory of these phenomena, namely uses topological methods to understand how global topology forces singularities. The governing notion of global singularity theory is &quot;Thom polynomial&quot;. The proposer has a strong research record on computing and applying Thom polynomials in various topological settings, eg. differentiable maps, forms, quivers, discriminants. The objective of the proposal is to support the proposer&apos;s career development by extending his expertise from {\em topology} to modern geometry and related geometric and algebraic combinatorics. Visiting the Renyi Mathematical Institute in Budapest for a year, doing training and research under the supervision of A. Nemethi (scientist in charge) will significantly develop and widen the competences of the researcher. The equivariant techniques Rimanyi used in the theory of singularities is proposed to be applied in geometrically relevant situations. The two concrete proposed projects are the study of matroid versions of linear Gromov-Witten invariants, and the geometry of natural stratifications on punctual Hilbert schemes of high dimension spaces.

Keywords: physical sciences,mathematics,geometry,algebraic geometry,algebraic topology
The consolidation of systems biology research – stimulating the widespread adoption of systems approaches in biomedicine, biotechnology, and agri-food (ERASYSBIO+)

Framework: FP7 — Cooperation
Programme: General Activities
Destination: ERANET
Action type: Coordination and support actions
Partnership: ERASYSBIO+ (ERA-NET)
Countries involved: Germany,Germany,Austria,Finland,France,Netherlands,Slovenia,Spain,Luxembourg,Israel,United Kingdom
Call:  (FP7-ERANET-2008-RTD, 2008)
Start date: 2008-10-01
End date: 2013-09-30
Duration (months): 60.0
Total project cost (EUR): 24004209.8
EU funding (EUR): 5500000.0
Participants: 13
Project status: CLOSED

Systems biology is still considered a young discipline in the field of life sciences. It integrates mathematics, chemistry, physics, informatics, engineering and other fields in biological research. The fragmentation of the discipline concerns all levels of the field: (i) It confronts researchers with a new combination of knowledge, methods, skills and expertise from different disciplines. (ii) It challenges funders overcome obstacles hindering cross organisational funding - across national boarders. (iii) It dares policymakers set goals outside the limits of preconceived structures. It is the interdisciplinary that makes collaboration imperative - on all levels. Therefore the ERASysBio+ partners firmly believe that systems biology offers the ideal vehicle to implement pan-European collaboration in order to overcome the still success limiting fragmentation within systems biology. The aim of this proposal is to implement a large transnational call enabling transnational, collaborative research projects in systems biology research. The funding organisations represented by this consortium are aiming to i.) jointly pave the way for systems biology research to interact outside the boundaries set by national regulations, ii.) widen the landscape beyond that of well established groups and contribute to integrating groups from regions where the systems approach and its funding are only just emerging. The ERA-NET-Plus instrument is the only instrument to effectively combine national and European funding efforts in a efforts in a joint funding measure achieve the abovementioned ambitious goals. .

Keywords: systems biology,era,era-net plus call,erasysbio+
In-vivo microstructure of the cornea: implications for vision, health, and disease (MICROCORNEA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-04-01
End date: 2011-03-31
Duration (months): 24.0
Total project cost (EUR): 246377.09
EU funding (EUR): 246377.09
Participants: 1
Project status: CLOSED

The research proposal MICROCORNEA will bring knowledge and expertise concerning in-vivo microstructural analysis of the cornea from Canada to Sweden, to be applied in innovative clinical and basic science research projects. The objectives of this proposal are to utilize in-vivo microstructural analysis to evaluate the biointegration of novel materials implanted in patient eyes for the restoration of vision, to detect the recurrence of dystrophic changes in patients after excimer laser treatment, to describe the microstructural corneal features in Swedish families with new, hereditary corneal dystrophies, to develop a means to detect lymphangiogenesis non-invasively in a live cornea, and to non-invasively observe phenotypic changes in corneal stromal cells in real-time. These objectives will be achieved by first imaging the microstructural characteristics within live corneas by using in-vivo laser-scanning confocal microscopy, and subsequently quantifying, analyzing, observing, and interpreting the various anatomic features of the cornea at the microscopic level, and relating the findings to the specific research questions posed. Research results will be disseminated at conferences and scientific meetings and will result in the submission of a minimum of six articles to international, peer-reviewed scientific journals. The expertise of the Incoming Research Fellow will be additionally applied to train researchers from Sweden and the Scandinavian countries to perform in-vivo laser-scanning confocal microscopy and microstructural analysis of the cornea. Once completed, the innovative research outlined in this proposal will establish the Host Institution in Sweden as a premier facility for innovative corneal microscopy research in Europe and will promote long-term research relationships between Canadian and Swedish corneal researchers within the two institutions.

Keywords: ophthalmology,clinical medicine,transplantation,rare diseases,diagnostics,clinical analysis,general pathology,chronic diseases
Functional characterization of a novel rheumatoid arthritis susceptibility locus on chromosome 6q (FERAL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-06-01
End date: 2011-05-31
Duration (months): 24.0
Total project cost (EUR): 171867.63
EU funding (EUR): 171867.63
Participants: 1
Project status: CLOSED

Rheumatoid arthritis (RA) is the commonest inflammatory disease of synovial joints. Approximately 50% of genetic susceptibility to RA is accounted for by the HLA-DRB1 gene together with the PTPN22 gene. A whole genome association (WGA) scan recently carried out by the Wellcome Trust Case Control Consortium (WTCCC) and subsequent validation studies have confirmed that an additional susceptibility locus maps to an inter-genic region of 6q23, near the TNFAIP3 gene. This is a strong candidate RA susceptibility gene as it is induced by TNF, a key inflammatory cytokine in RA. The aim of the project is to characterise the aetiological variant within this region and determine its role in RA susceptibility. The region is being re-sequenced in 80 individuals comprising both cases and controls to include representation of all 3 genotypes. Fine mapping studies will then be undertaken in the original samples included in the WTCCC study to identify the most strongly associated variants in the region. That data should be available by the start of the proposed Fellowship. I will test the most associated variants in an independent validation cohort of 5000 RA samples and 3800 healthy controls from the UK to confirm the most associated variant(s) and characterise the haplotype structure and linkage disequilibrium present in the region. Subsequently, bioinformatic resources will be used to investigate whether the associated variants mapping are associated with expression levels of genes in the region (particularly TNFAIP3) or are predicted to bind transcription factors. Functional studies will then be undertaken to clarify the role of these variants in RA ethiopathogenesis using techniques including luciferase reporter gene assays, electromobility shift assays, expression studies and analysis of protein levels. Experiments will be performed using relevant cell lines and tissues under both basal and TNF-stimulated conditions.

Keywords: health sciences,population genetics,chronic diseases,rheumatology
Random walks on hyperbolic groups (RWHG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-10-01
End date: 2010-11-30
Duration (months): 14.0
Total project cost (EUR): 156712.58
EU funding (EUR): 156712.58
Participants: 2
Project status: CLOSED

The project lies at the confluent of different mathematical fields: probability theory, algebra, and geometry. There is a contribution of A. V. Vershik in a special Springer volume about the future of mathematics in the 21st century that points out the prospects and challenges that are comprised in the interplay of probability theory and algebra. Here random walk theory, a branch of probability theory, plays a mayor role. There are two points of view to look at the relation between probability theory, algebra, and geometry. The probabilistic viewpoint concerns all questions regarding the impact of the underlying structure on the behavior of the corresponding random walk. Typically one is interested in transience/recurrence, spectral radius, rate of escape, and central limit theorems. On the other hand, random walks are a useful tool to describe the structure that underlies the random walk. In particular, algebraic and geometric properties can be classified due to the behaviour of the corresponding random walks. The project falls exactly into this topic: we will study random walks on hyperbolic groups. The objectives are to prove a central limit theorem for random walks on hyperbolic groups and provide geometric interpretations of the asymptotic variance. This will arise from a geometric perspective in the flavour of the interpretation for the rate of escape in terms of entropy and requires deeper knowledge of hyperbolic geometry together with inspiration and new ideas. The project will settle the ground for future collaboration, not only between France and Germany but also on an European level, since the host institute and the applicant have strong European contacts. Furthermore, the project can be seen as a continuation and complement of the existing Marie Curie contract ``European Training Courses and Conferences in Group Theory&apos;&apos;.

Keywords: probability theory,group theory,geometry
Biochemical characterization of Arabidopsis Fe uptake transporter IRT1 (BIOCHEMIRT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-01-06
End date: 2011-02-05
Duration (months): 13.0
Total project cost (EUR): 168279.59
EU funding (EUR): 168279.59
Participants: 1
Project status: CLOSED

Iron is an essential nutrient. It is involved in a great variety of biological processes, such as photosynthesis or the oxidative respiration. Iron deficiency is a factor limiting crop production, and the most important dietary deficiency in humans. In order to address these problems, plant iron uptake has been studied with detail. As a result, metal transporters of the ZIP family have been identified as the main responsibles for iron uptake from soil in plants, with the exception of some grasses. However, very little is known on their biochemistry and on the shuttling of iron in the cytosol. The aim of this proposal is to biochemically characterized these ZIP transporters, using as a model Arabidopsis thaliana IRT1. This transporter has successfully been expressed in yeast, where it is still active and therefore is susceptible of being purified in an active form. Oligomeric state of the protein, metal specificity and kinetical parameters will be determined in vitro, by means of fluorescent probes specific for the different transport substrates. Similarly, the possibility of cotransport will be evaluated. Metal affinity, metal binding site/-s will be determined by the use of fluorescent probes and site directed mutagenesis, and further verified with X-ray spectroscopy. The acceptor from the iron introduced by IRT1 will be identified by means of copurification, coimmunoprecipitation or by chemical crosslinking. All these results will be further validated in vivo in an Arabidopsis irt1-1 background. As a result of this work we will determine how IRT1 works, the first time that this would be done in a ZIP transporter. These results will be used in the characterization of other ZIP transporters regardless their origin, plant, animal, bacteria ,…. and explain at a molecular level the etiology of some diseases. However, primarily, these results could indicate new strategies to improve plant iron nutrition in areas where deficiency is prevalent, such as eastern Spain

Keywords: plant nutrition,biochemistry