Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Zero Emission electric Vehicles enabled by haRmonised circulArity (ZEvRA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Partnership: 2ZERO (co-programmed)
Countries involved: Germany,Italy,Türkiye,Norway,Belgium,France,Spain,Finland,United Kingdom,Hungary,Czechia,Sweden,Slovakia
Call: Circular economy approaches for zero emission vehicles (2ZERO Partnership) (HORIZON-CL5-2023-D5-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 11382948.5
EU funding (EUR): 11382948.5
Participants: 31
Project status: SIGNED

ZEvRA's main objective is to improve the circularity of light-duty EVs throughout their entire value chain, from materials supply and manufacturing to end-of-life (EoL) processes, which aligns with the European Union's goal of achieving zero CO2e emissions by 2035, particularly in the EV value chain. To do so, ZEvRA will develop a Design for Circularity (DfC) methodology and a holistic circularity assessment aimed at improving the production of electric vehicles (EVs) based on the 9Rs. This methodology will be validated by developing zero emission solutions for the most important automotive materials, covering > 84% material mix: steel, three versions of aluminium (wrought, casting, and foam), thermoplastics composites (long and continuous fibre-reinforced), unfiled/short fibre plastics, glass, tyres and Rare Earth Elements (REE). These solutions will be supported by a set of digital tools to support the manufacturing of the use cases, the assessment of circularity, traceability, and the virtual integration of components into a full replicable vehicle. To maximise the outreach of our methodology and zero emission solutions, ZEvRA will develop a dedicated training & upskilling programme for the automotive workforce and academia, together with activities aimed at increasing awareness & acceptability of the proposed zero emission solutions. Lastly, circular business models targeting EoL and logistics aimed at improving the economic feasibility of circularity in EVs are advanced. ZEvRA’s innovations aim to improve zero emission approaches in the life cycle and value chain of at least 59% of European EVs by 2035 through the 5 OEMs and Tier 1’s that are part of the consortium, which includes industry and academia covering the entire automotive value chain.

Keywords: lightweight circularity automotive
Connecting mitochondrial defects to reduced autophagy in metabolic liver diseases through FATP2. (MITOTUA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Hepatic mitochondrial dysfunction is a common clinical feature of several metabolic disorders, including type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH). Mitofusin 2 (MFN2), a transmembrane protein necessary for mitochondria-endoplasmic reticulum tethering, is decreased in T2D and NASH. Moreover, its liver-specific ablation promotes the manifestation of NASH and increases the susceptibility to developing liver cancer in mice. Recently, the Zorzano lab has identified several interactors of MFN2 involved in lipid transport. The "MITOTUA" project focuses on the study of FATP2, a fatty acid transporter/acyl-CoA synthetase predicted to participate in mitochondria-associated autophagosome formation during starvation. We plan to perform a battery of in vitro and in vivo experiments to properly characterize the mechanistic implications of MFN2-FATP2 interaction to autophagy activation and mitochondrial function. The "MITOTUA" project will also investigate the relevance of FATP2 to the hepatic alterations connected to the metabolic syndrome by using murine models of liver steatosis (ob/ob and db/db mice) and NASH (CDAHFD diet) and analyzing liver biopsies of patients with fatty liver disease. The combination of my strong background in complex metabolic syndromes and the well-recognized expertise of the Zorzano lab in the study of autophagy and mitochondrial metabolism will undoubtedly result in a well-conducted scientific project and a successful reciprocal transfer of knowledge. Overall, this fellowship represents a unique opportunity to enroll in a prolific research group of a distinguished institution, taking advantage of an ecosystem shaped to maximize the potential of this proposal and acquire new competencies that complement my scientific preparation, reaching the professional maturity necessary to become an independent researcher in the forthcoming years.

Keywords: mitochondria,autophagy,mfn2,fatp2,non alcoholic steatohepatitis nash,metabolic syndrome,type 2 diabetes
Next Generation 3D Tissue Models: Bio-Hybrid Hierarchical Organoid-Synthetic Tissues (Bio-HhOST) Comprised of Live and Artificial Cells. (Bio-HhOST)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Italy,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 24.0
Total project cost (EUR): 508088.75
EU funding (EUR): 508088.75
Participants: 2
Project status: CLOSED

Bio-HhOST is developing bio-hybrid materials that integrate live and artificial cells (ACs) in dynamic communication, enabling precision-engineered, biochemically programmable, and responsive ACs to influence the proliferation, differentiation, and function of living cells. This innovative approach paves the way for next-generation organoid models, driving fundamental research and technological advancements in disease study, drug screening, and biotherapeutics’ delivery. The Hop-on proposal adds a new layer of biochemical information to the existing Bio-HhOST methodologies by conducting omics-based biomolecular profiling of the 3D tissue models being developed, including their artificial and live cell components. The multi-omics platform will integrate proteomics, lipidomics, and metabolomics to provide a comprehensive view of the molecular characteristics and interactions that govern cellular behaviour and specific biological processes. Identifying protein, lipid, and metabolite markers related to cell function and tissue differentiation will enhance our understanding of artificial cell biochemistry and the interplay between ACs and live cells, accelerating and deepening their functional integration. This will serve as a novel tool to optimize AC design and organoid culture conditions, improving the control and biomimicry of Bio-HhOST bio-hybrid models.

Keywords: metabolomics,lipidomics,proteomics,lc ms,nmr,bioinformatics,biomolecular profiling,cell metabolism,artificial cells,bio hybrid organoids,3d tissue models
The Social Life of Dead Bodies. A new ethnographic approach to migrant deaths in and around the Mediterranean Sea (SOLID)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1496394.0
EU funding (EUR): 1496394.0
Participants: 1
Project status: SIGNED

Thousands of people have died in the attempt to migrate into Europe through irregular channels. In fact, 2023 has seen the highest number of migrant deaths in the Mediterranean since 2017 . We only ever see very few of these bodies. Some die in the deserts of Sudan and Libya never to be found, others get stuck inside shipwrecks at the bottom of the Mediterranean Sea. Even the dead bodies that end up on the shores of Europe often remain unknown and thus socially obscure. However, in their local communities left behind, the dead and missing continue to hold great social importance. SOLID presents an innovative theoretical and methodological approach to understanding the social life of deceased migrants by employing a research strategy that is ethnographic, global and collaborative. The aim is to promote the humanisation and social visibility of deceased migrants by creating a broader understanding of the human lives behind the tragic statistics of migrant deaths. The SOLID research project introduces the analytical lens of social anatomy, which refers to the configurations of social arrangements that emerge around missing or deceased migrants as various people and organisations employ practices of determination to identify, understand and/or keep indeterminate who has passed away and how. By bringing together forensic, social, economic, humanitarian, political and criminological actors and perspectives on the same unidentified bodies of deceased migrants, SOLID pursues an innovative analytical approach to the anthropology of death, and specifically to dying in anonymity. It highlights the social importance of missing and deceased migrants in their communities as well as in Europe by tracing the social concerns left behind in Somaliland, Morocco, Greece and Spain through the innovative methodological approach, generative collaborations. This method captures the multiple configurations of knowledge and practices as different actors respond to the same dead bodies.

Keywords: criminalization,irregular migration,migrant deaths,anonymous death,missing migrants,social life,identification practices,eu policies
NGI Commons - Open Source and Internet Commons for Europe’s Digital Sovereignty (NGI Commons)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Coordination and support actions
Countries involved: Netherlands,Belgium,France,Switzerland
Call: Next Generation Internet Commons Policy (CSA) (HORIZON-CL4-2023-HUMAN-01-CNECT, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 6
Project status: SIGNED

The NGI Commons project aims to align and integrate Next Generation Internet (NGI) efforts within the broader European Digital and Internet Commons (DC/IC) landscape, addressing key governance issues such as digital sovereignty, cybersecurity and personal data self-determination. To achieve the EC Call objectives, the project’s consortium combines expertise in Digital/Internet Commons, Open Source, the European digital policy landscape with a deep understanding of the overall NGI initiative. Digital Commons, including open source software, hardware, design, standards and data, are essential to support sovereignty, trust and democratic values in society. Their economic and geopolitical importance has been recognized in the EU's Digital Decade Strategy. To unlock the full potential of Digital Commons, efforts must be made to overcome fragmentation and bridge the gap between bottom-up movements and top-down regulatory efforts, a role that the NGI Commons project can effectively play. The project's approach focuses on creating value for all stakeholders in the NGI community and facilitating access to NGI resources and funding for DC/IC initiatives. It leverages the consortium's deep understanding of NGI tools and mechanisms and its well-established connections across Europe and beyond. The project will conduct a thorough economic analysis of the NGI initiative's impact and the broader DC/IC landscape, which will contribute to creating a strategic agenda for supporting Digital Commons throughout the current MFF period and beyond. The main objective is to help the NGI initiative to integrate and align with other European and national Digital Commons policies in order to develop a long-term strategy that is critical for sovereignty, trust and European democratic values. The ultimate ambition is to create a more coherent European funding landscape to make the Digital Commons a core building block of EU digital sovereignty and public digital infrastructure.

Keywords: digital commons,digital sovereignty,policies
Cable Aerial Based Low-altitude Systems for Snowpack Spatialized Sensing (CABLE-SENS3)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,Switzerland,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-02
End date: 2028-12-01
Duration (months): 42.0
Total project cost (EUR): 461934.3
EU funding (EUR): 461934.3
Participants: 4
Project status: SIGNED

Alpine snowpack dynamics are crucial to hydropower generation, irrigation, winter tourism, and avalanche and flood forecasting. The ability to predict snowpack fluctuations is essential for ensuring economic stability and public safety in both alpine and downstream regions. However, current snowpack monitoring techniques are labor-intensive and provide only sparse, large-scale data, which limits the capacity to capture rapid and localized changes. This poses a significant challenge in addressing key operational needs. Cryospheric scientists have therefore identified the collection of spatiotemporal data on snowpack variability, particularly along elevation gradients, as a top research priority. The overall aim of the CABLE-SENS3 project is thus to develop an innovative snowpack monitoring system that addresses these challenges. The project proposes to use passive RFID tags, combined with an aerial RFID reader mounted on a cable car, to continuously monitor snowpack properties across large elevation gradients. This approach offers a breakthrough by merging high-resolution spatial and temporal data—something current methods cannot achieve simultaneously. Additionally, the proposed system is non-invasive, overcoming the limitations of traditional methods that rely on low-frequency or intrusive measurements. Incorporating technologies such as photogrammetry and microwave geophysics will enable the system to measure variables like snow water equivalent (SWE), liquid water content (LWC), and snow depth. By deploying RFID tags across large, often inaccessible areas, and conducting frequent aerial surveys, the project will generate unprecedented spatiotemporal data on snowpack dynamics. Such data will be invaluable to stakeholders such as hydropower companies, ski resorts, and avalanche safety services, who increasingly depend on data-driven decision-making. Moreover, the project will provide critical data to address many scientific questions related to the impacts of cli

Keywords: snow science avalanches snowpack dynamics aerial remote sensing distributed sensing radar insar rfid passive microwave sensors
A Newly Identified Cilium in Meiosis - Deciphering the Principles and Mechanisms of the Zygotene Cilium (ZygoCiliaAct)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

A hallmark of meiosis is chromosomal pairing, which for decades has been a major focus in the field. However, the nuclear events of meiosis occur in the cellular context of a differentiating gamete, and pairing depends on cytoplasmic counterparts, by mechanisms that are conserved from yeast to mammals. These are essential for fertility, but how cytoplasmic counterparts of chromosomal pairing are regulated has remained enigmatic. We uncovered a previously unrecognized cilium in meiosis – the zygotene cilium, in both males and females and in zebrafish and the mouse, which completes the mechanical cytoplasmic pairing machinery, and extracellularly extend between oocytes within a conserved cellular hub, called the germline cyst. We established the ground-breaking observations that the cilium is essential for chromosomal pairing, prophase progression and cyst morphogenesis, ovary development and fertility. These uncover the novel concept of a cilium as a critical player in meiosis, propose a cellular paradigm that cilia can control chromosomal dynamics, and shed new light on reproduction phenotypes in human ciliopathies. The zygotene cilium now allows us to zoom-out from the nuclear events of prophase to the complete cellular and developmental program of meiosis. Utilizing our holistic morphological approach in-vivo, ZygoCiliaAct will ambitiously achieve this goal in three related but independent aims. We will uncover zygotene cilium functional mechanical and regulatory components (Aim 1), decipher the ciliary developmental signals that govern meiotic prophase progression and cyst morphogenesis (Aim 2), and expand our findings to investigation in testes, as well as use zebrafish as a new model to decipher mechanisms of human ciliopathic proteins (Aim 3). With ZygoCiliaAct we are finally poised to break new grounds in unraveling long-sought-after fundamental questions cell, developmental, cilia, and reproductive biology, and advance reproduction and ciliopathy medicine.

Keywords: meiosis,cilium,oogenesis,chromosomal pairing,morphogenesis,ovary,centrosome mtoc,zebrafish,germ cell development,spermatogenesis,ciliopathy,reproduction and fertility,live imaging
Findustrial - Equipment-as-a-service powerhouse (Findustrial)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Austria
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 2200000.0
EU funding (EUR): 2200000.0
Participants: 1
Project status: SIGNED

Findustrial GmbH, is a multi-award-winning fintech startup based in Schörfling/Upper Austria and was founded early 2020. Findustrial develops a financial platform based on the Internet of Things that provides pricing, billing & invoicing as well as risk & financing services for different stakeholders for Equipment-as-a-Service business models. The revolutionary and highly scalable Equipment-as-a-Service platform covers the end-to-end cycle from sales with model configuration, calculation and offer creation over flexible pay-per-use financing service to billing & settlement of customer contracts. With the first official market product, a Pay-per-Use flexible lifetime model together with our development partner Erste Group and Sparkassen Leasing we could successfully prove the technical feasibility of the Findustrial IoT Data Store as well as the relevant software platform and achieve a major milestone on our journey towards a world of successful Equipment-as-a-Service business models.

Keywords: fintech,equipment as a services,circular business model,blockchain,sustainability,efficiency,iot
First adaptive eyewear to offer perfect vision for people with myopia and progressing presbyopia (Perfect Vision)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Finland
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 3552500.0
EU funding (EUR): 2486750.0
Participants: 1
Project status: SIGNED

Eyesight is our most critical sense providing over 80% of our sensory impressions, but in the modern world people’s eyesight has become significantly worse. It is the result of irreversible megatrends of increasing indoor lifestyle with high use of digital devices and aging population. While the former affects the development of young eye causing shortsightedness, then population aging leads to higher prevalence of inevitable aging related farsightedness. Moreover, with an aging population, economies increasingly rely on an aging workforce among whom the prevalence of both vision problems is continuously expanding. To prevent this problem from weighing down people’s productivity as well as their personal wellbeing, Pixieray introduces breakthrough adaptive eyewear technology to effectively provide perfect vision for those whose eyes are naturally not up to it anymore. While progressive eyewear with static lenses is currently the primary remedy for correcting near and far sight vision, they severely limit field of clear vision for different distances, create peripheral vision distortions and cause physical discomfort through dizziness and neck strain. In contrast, Pixieray uses its proprietary liquid crystal lens technology combined with the world’s smallest and power efficient IR based eye tracking solution to dynamically adjust eyewear’s optical power given the user’s viewing distance and prescription strength. This allows the wearer to see clearly at every distance with full field of vision and without distortions and physical discomfort.

Keywords: adaptive eyewear,tunable liquid crystal lens,ir eye tracking,myopia,presbyopia