Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
CoPackaging of Terabit direct-detection and coherent Optical Engines and switching circuits in mulTI-Chip moduleS for Datacenter networks and the 5G optical fronthaul (POETICS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Italy,Israel,Germany,Belgium,Greece,Greece,Netherlands
Call: Application driven Photonics components (H2020-ICT-2019-2, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 5814569.03
EU funding (EUR): 5814568.75
Participants: 8
Project status: SIGNED

Enabling Terabit capacity optical interconnects requires a paradigm shift in the packaging approach. The electrical interconnect distance between the optical engine (OE) and the digital switching chip must be minimised, removing signal conditioning chips and unwanted components like sockets that would otherwise be required and would inevitably lead to increased power consumption and lower signal integrity. It also requires the right combination of photonic and electronic technology that will be integrated to deliver high performance, low-cost and energy efficient optical engines. This approach has the potential to remove the optical interconnect bandwidth bottlenecks and allow DC networks and the 5G wired infrastructure, which heavily rely on them, to grow. POETICS is a research proposal that targets the development of novel Terabit optical engines and optical switching circuits and to copackage them with digital switching chips to realise Multi-Chip Modules (MCM) with Tb/s capacities, very high energy efficiency that fit into the roadmap of vendors. In order to do so POETICS will utilize SiGe BiCMOS, InP, PolyBoard and TriPleX technologies and rely on hybrid integration, which allows the selection and combination of the best performing components. POETICS in specific targets 1) MCM with 1.6Tb/s OEs based on 8-fold InP-EML arrays (200Gb/s per lane) and PolyBoard with parallel SMFs on par with the PSM/DR spec for 500m-2km intra-DC connectivity. 2) MCM with 1.6Tb/s OEs based on 8-fold InP-EML arrays (200Gb/s per lane) and 3D PolyBoard with duplex MCFs for 5G optical fronthaul applications 3) low power consumption 3D Benes optical switch 4) MCM coherent 64Gbaud OEs with up to 600Gb/s capacity of DC interconnect applications within 80-120 km reach on par with 400G-ZR specification.

Keywords: optical interconnects,co packaged optical engines,coherent transceivers,dc interconnects,short reach optical communications,hybrid integration,photonic packaging
Industrialisation of curved sensors and related imagers (CURVE-X)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France,France
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 149850.0
EU funding (EUR): 149850.0
Participants: 3
Project status: CLOSED

Pillar II of the ERC-STG-ICARUS aimed at paving the way to a common use of curved sensors for cost-effective imaging systems, through prototyping and recommendation for mass production. The next steps towards commercialisation and industrialisation are proposed in this PoC project to: improve the repeatability, prepare the industrialisation, realise market studies and outline a business plan. We create the start-up CURVE-ONE for the valorisation towards scientific instrumentation and amateur astronomy. The project has the positive support of potentiel clients and will be done with the help of CNRS-Innovation as a third party and the OPTITEC photonics competitiveness cluster to enhance the impact on industry.

Keywords: curved sensors,curved detectors,imagery,optical systems,optics
Commensal microbiota regulation of neuro-immune networks (CeleSte)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-01-2018, 2018)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

The enteric nervous system (ENS), neuronal and glial cells, development and function can be influenced by the microbiota. Germ-free mice have defective maturation of enteric glial and neuronal cells; colonization with microbiota rescues these defects. Production of neuroregulatory molecules by these neuronal cells involved microbial product sensing via MYD88. Importantly, glial-specific or neuron-specific deletion of Myd88 leads to decreased intestinal neuroregulators and consequent impaired innate lymphoid cell (ILC) activation. The identity of commensal microorganisms and the neuronal and glial cells sensing molecular pathways that could influence neuroregulators secretion affecting neuroimmune interactions are unknown. By using neuronal-specific mutants and their colonization with distinct microbiota, the present project aims to understand how glial- and neuron-derived regulators are influenced by particular commensal microorganisms and how this active neuronal sensing impacts of defined neuroimmune cell units, notably on the glial-ILC3 and neuron-ILC2 interactions. For this purpose, we will take advantage of a strong collaborative environment and cutting-edge techniques, including gnotobiotic animals, cre-lox technology, and neurosphere-derived organoids. Deciphering these new pathways of ENS-microbial crosstalk will improve our understanding of this equilibrium and will contribute to the development of new therapeutic strategies in mucosal diseases. This highly innovative and interdisciplinary project will allow me to expand my conceptual and technical knowledge of the host-microbiota dialogue, acquire new technical skills and reinforce my scientific network.

Keywords: enteric nervous system,microbiota,innate lymphoid cells,glial cells,neuro immune interaction,neuroregulators,neurons
Open Science Innovation in PhD programme through Earth Observation: towards new career skills development (InnEO Space_PhD)

Framework: Horizon 2020 — Science with and for Society
Programme: Make scientific and technological careers attractive to young students, and forster sustainable interaction between schools, research institutions, industry and civil society organisations
Action type: Coordination and support actions
Countries involved: Italy,Romania,France
Call: Research innovation needs & skills training in PhD programmes (H2020-SwafS-2020-1, 2020)
Start date: 2020-12-01
End date: 2023-05-31
Duration (months): 30.0
Total project cost (EUR): 311625.0
EU funding (EUR): 311625.0
Participants: 5
Project status: SIGNED

InnEO’Space_PhD project aims at preparing post-graduate candidates and early stage researchers for a successful career through modernised and transferable PhD courses based on innovation skills and employers’ needs. To achieve this, the project will enhance and develop researchers’ innovation-oriented mind-sets and skills through Earth Observation, that offers a multidisciplinary approach and numerous applications in various sectors (environment, climate change, crisis management…). By converging to a joint PhD profile, synergies between universities will be enhanced to promote exchanges and mobility. The project will also create new synergies between: - PhD students and researchers and potential employers, and, - the universities and the private sector. Indeed, the consortium will collaborate with companies, SMEs and clusters to develop the activities, enhance PhD students and early sThe aim of the Open Science innovation in PhD programme through Earth Observation is to prepare young researchers for a successful career by developing modernised PhD courses based on innovation skills and employers’ needs. By implementing four pilots at a large scale and across Europe in the multidisciplinary case of Earth-Observation science applications, the consortium will get a broad mapping of best practices to develop a e-learning course and a PhD career tool kit that will remain accessible after the end of the project. The e-learning course will then be a useful tool for any university, which wants to foster new careers for PhD students and researchers from any domain by providing them with transferable skills to fit the European industry and stakeholder needs other than academic labs. The InnEO’Space_PhD shall stand for a special academic excellence for future scientific leaders in any field related to EO, enlarging their training and experience with soft skills, environment monitoring, open science and entrepreneurship, that are needed elements for innovation at any level.

Keywords: earth observation,entrepreneurship,innovation
SCALEFORES: Scaling Rules For Ecosystem Service Mapping (SCALEFORES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-07-01
End date: 2023-05-31
Duration (months): 83.0
Total project cost (EUR): 1483096.0
EU funding (EUR): 1483096.0
Participants: 1
Project status: SIGNED

It is now widely recognized that sustainably managing ecosystem services – the benefits humans obtain from nature – is essential for humanity’s prospects in the 21st century and beyond. However, at present there is little data on the distribution of most services in most places. To date, the discipline of ecosystem service mapping has tried overcome this lack of data by using proxies to map ecosystem services based on our perceived understanding of ecosystem services from small-scale studies. However, the most commonly used proxies have been shown to be inaccurate, particularly for understanding policy-relevant trade-offs and win-wins between ecosystem services. The challenge therefore remains - how do we reliably map such relationships between multiple ES, thereby enabling multifunctional, ES-based management of our landscapes? In the SCALEFORES project, I will address this challenge head-on by developing and testing a novel methodological framework that enables the use of existing data to produce accurate maps of the relationships between ES in previously unmapped regions. The overarching idea underpinning SCALEFORES is that we can use information on the scale-dependency of relationships between existing social and ecological datasets (e.g. land cover, soil type, human population density) to create maps of trade-offs and win-wins between ecosystem services. The SCALEFORES project will systematically examine the scale-dependency of relationships between ecosystem services and the social and ecological variables that underpin them. It will then use this knowledge to enable a step change increase in our ability to accurately map both relationships between ES and the distributions of ecosystem services themselves. The methodology developed in SCALEFORES will be validated against existing maps of ecosystem services in Europe, as this is the region with the best data on ecosystem services globally.

Keywords: ecosystem services
Lordship and the Rise of States in Western Europe, 1300-1600 (STATE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 1496875.0
EU funding (EUR): 1496875.0
Participants: 1
Project status: CLOSED

This project pursues a new interpretation of state formation in Western Europe between 1300 and 1600. This period is considered as the key phase in the genesis of the modern state, as various polities now centralized fiscal and military resources under their command. While there is debate whether this was primarily a top-down process carried by princes, or a bottom-up process carried by popular representation, scholars agree that state building was exclusively a process of centralization. This assumption must be questioned, as recent studies have raised awkward questions that cannot be answered by the current paradigm. The research hypothesis is that the emerging states of Western Europe could only acquire sufficient support among established elites if they also decentralized much of their legal authority through a process in which princes created a growing number of privately owned seigneuries as “states-within-states” for the benefit of elites who in return contributed to state building. This project will study the interplay between states and seigneurial elites in five regions – Flanders, Guelders, Normandy, Languedoc and Warwickshire – to test whether fiscal and military centralization was facilitated by a progressively confederal organization of government. Together, the case studies cover four key variables that shaped the relations between princes and power elites in different combinations all over Europe. It concerns different trajectories in 1) state formation, 2) urbanization, 3) the socio-economic organization of rural society and 4) ideological dissent. As a result, the comparisons between the case studies will yield an analytical framework to chart and to explain path-dependency. The project will put the social history of power in Western Europe on a new, improved footing and provide the methodological innovation that is necessary to integrate the political history of Western Europe between1300-1600 with that of Central- and Eastern Europe.

Keywords: state formation,elites,seigneurial lordship,social history of power
eXtreme ultraviolet to soft-X-ray Photonic Integrated Circuits (X-PIC)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Italy,Romania
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-04-01
End date: 2025-03-31
Duration (months): 48.0
Total project cost (EUR): 3075000.0
EU funding (EUR): 3075000.0
Participants: 4
Project status: SIGNED

This project aims at the realization of a new technological platform for the development of a EUV - soft X-ray integrated photonics. Integrated photonics is a growing sector of photonics devoted to the realization of optoelectronic devices integrated in a single unit able of complex functionalities, with numerous and increasing applications. Current technology shares several aspects with semiconductor electronics; for this reason, the electromagnetic spectrum involved in integrated photonics is essentially limited to the infrared-to-visible range by the semiconductor band gap. The development of a novel technology able to manipulate high-energy photons in integrated devices may open integrated photonics to novel frontiers; in particular, the spectral range going form the extreme ultraviolet to the soft X-rays is very attractive for applications in Micro- and Nanoelectronics, Biology, Pharmacology, Material and Surface Sciences, Chemistry, Physics, Metrology and in many other fields. The ambitious goals of the project will be reached through the synergetic interaction among different disciplines as Ultrafast Laser Technology, Extreme Nonlinear Optics, Femtosecond Laser Micromachining, Fluid Dynamics, Nanotechnology, EUV to soft X-rays technology. The partners involved in this proposal are leaders in those research fields, thus making the ambitious project goals feasible. The innovative technology demonstrated in this project will be the base for a large variety of future devices offered to industrial and scientific customers, with functionalities tailored to specific applications.
Feasibility assessment of an all‐in‐one nerve repair and regeneration product (ULTRANERVE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Peripheral Nerve Injuries (PNIs) are lesions of the nerves of the head or the extremities. Grand View Research estimates over 2 million cases of PNIs per year in the EU and the USA. These injuries remain incurable, resulting in permanent loss of body function as in paraplegia, leading to disabilities and heavy social burden. The chance to cure PNIs based on smart nano-engineered biomaterials will have a major positive impact in heavy and long term burdens on patients and healthcare systems. In this context, Nerve Biomed’s team, a spin-off company of the Polytechnic University of Valencia (Spain) has been leading an R&D initiative in advanced PNI reparation over the past 11 years, in order to develop and further commercialise ULTRANERVE: an easy-to-use medical solution for PNI regeneration, which is going to simplify medical procedures and reduce the average full recovery time, while decreasing significantly the average cost of actual repair procedures. Within the roadmap established by the company to commercialize the product internationally by 2020, Nerve Biomed wants to perform a thorough feasibility study, through this SME Instrument Phase 1, which will assess in detail the practical and economic viability of introducing this solution in the PNI repair and regeneration market ih the EU and the USA.

Keywords: peripheral nerve injuries,biohybrid scaffold,schwann cells,axonal growth,nanospheres,all in one solution,fast healing,large gap lengths
Euraxess Georgia Network Startup (EuGeNeS)

Framework: Horizon 2020 — Science with and for Society
Action type: Coordination and support actions
Countries involved: Georgia
Call: EURAXESS Georgia start-up (H2020-IBA-SWAFS-EURAXESS-GE-2019, 2019)
Start date: 2019-10-01
End date: 2022-09-30
Duration (months): 36.0
Total project cost (EUR): 200000.0
EU funding (EUR): 200000.0
Participants: 1
Project status: CLOSED

The goal of the EURAXESS Georgia Network Startup (hereinafter referred to asEuGeNeS) project is to start up EURAXESS Georgia, which will operate in harmony with pan-European EURAXESS and support research mobility, career development and international scientific cooperation at a national level. The primary objectives of the EuGeNeS are: 1. To establish the EURAXESS Service Centre at Georgian bridgehead organization with a leading role in coordination of the EURAXESS network at national level and representing Georgia at European level; 2. To set up and make fully operational EURAXESS Georgia network composed by the Georgian bridgehead organization (BHO), EURAXESS Service Centre (ESC) at BHO, and EURAXESS Contact Points (ECP) providing comprehensive information and personalized assistance for mobile and non-mobile researchers in their career development according to European quality standards; 3. To develop a fully operational Georgian national EURAXESS website integrated in the European EURAXESS portal. The website will cover 6 categories of information: (i) Jobs & Funding, (ii) Information & Assistance, (iii) Georgian network; (iv) Career development, (v) Partnering, (vi) News & Events. 4. To make Georgian national EURAXESS portal and network well adopted, popular and preferred source of information and support services for research mobility, career development, international for academic and scientific society, especially for outgoing, incoming or non-mobile professional researchers, as well as for research oriented institutions. 5. To implement and institutionalize good practices of information and service delivery to the non-mobile and mobile researchers and their families; facilitate operational sustainability of the EURAXESS Georgia network and safeguard viability of the Georgian national EURAXESS organization after the project completion on free of charge basis for the researchers in motion.

Keywords: euraxess,researchers mobility,career development,service network
Deciphering different layers of regulation of FLOWERING LOCUS D, a bZIP transcription factor that promotes flowering of Arabidopsis (FD Net)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

Floral transition denotes the initiation of plant reproduction. Several genetic pathways regulate this important transition and many of them converge on the regulation of FLOWERING LOCUS T (FT), the systemic flowering signal that moves from leaves to the shoot apex. FT reprograms transcription at the shoot apex by contributing to Florigen Activation Complex (FAC). A central component of this complex is the bZIP transcription factor FLOWERING LOCUS D (FD), which is responsible for DNA binding and gene specific regulation by the complex. I will employ single-cell RNA sequencing to capture the transient cell state where the FAC complex and two different target genes, APETALA1 and SOC1, are coexpressed. Defining the transcriptomic network of FD at the single-cell level will provide a deeper understanding of this dynamic process. Phosphorylation of a threonine residue in the SAP motif at the C terminus of FD is a key step in formation of the complex. Phosphomimetic or non-phosphorylatable FD SAP motif versions have opposite effects on FD function, being able or not, respectively, to complement the late flowering phenotype of fd-3. I will investigate whether SAP motif phosphorylation affects FD protein stability or impairs its protein-protein interactions using confocal microscopy and protein mass spectrometry. In addition, other bZIPs closely related to FD are phosphorylated at other sites, but no analysis of FD phosphorylation sites other than the SAP motif has been presented. I will map post-translational modifications of FD, which may reveal new regulatory steps in controlling FD activity. I will explore the ability of FD to form protein complexes with other transcription factors by employing yeast-two hybrid, protein pull-downs and interaction studies using immunoprecipitation-mass spectrometry and biotin-based proximity labeling. The identification of new FD protein interactors will start reverse genetic and biochemical approaches to better understand FD function.

Keywords: flowering,post translational modifications,protein protein interaction,single cell transcriptomics