Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Synergistic effects of DISpersant, oil and HYpoxia in a teleost fish: Investigating the impact of oil contamination in hypoxic areas and the use of dispersant as a response technique (DISHY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-30
End date: 2017-04-29
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Coastal marine ecosystems are of high socio-economic and ecological importance. However, these ecosystems are under anthropogenic pressures. Among these anthropogenic pressures, two major growing threats are represented by hypoxia (due to eutrophication) and oil pollution. These 2 major threats are particularly presents and coexist in European marine coastal ecosystems. However, scarce studies have investigated the biological impacts of their interaction. Consequently, this project intends to evaluate the potential biological effects caused by oil pollution in hypoxic situations. Additionally, this project will consider dispersant use as a response technique for oil released in these hypoxic areas. Practically, the research actions will estimate the synergistic biological effects of dispersant, oil and hypoxia on a teleost fish species of ecological and economic importance for Europe: the sea bass Dicentrarchus labrax. The approach will firstly evaluate the hydrocarbons contamination induced by the interaction of stressors (Work Package 1). Then, biological effects will be evaluated, at the sub-individual level, by assessing sensitive indicators related to oxidative stress (Work Package 2). Finally, indicators of ecological significance, related to fish behavior, locomotion and metabolism, will be assessed at the organismal level (Work Package 3). The complementarity between the fellow and the supervisors’ profiles and the environment provided by the host and partner organizations insure the achievement of this timely and innovative project as well as the dissemination and exploitation of the expected results. These outputs will permit to inform decision makers on the ecological and environmental issues of oil spill in hypoxic areas and to advise oil spill responders on the appropriateness of dispersant use in these areas.

Keywords: fish,behavior,dispersant,hypoxia,oxidative stress,contamination,antioxidant,locomotion,oil spill
Demonstration of a novel and scalable, compact air purification module for HVAC systems and ducts – the Nano Purifying System (NPS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Portugal
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-10
End date: 2018-11-09
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

VLopes is an SME accounting for 20 years of experience in designing, developing and delivering air conditioning, ventilation and environmental control solutions such as air handling units (AHU) for leading players across industry sectors (incl. Airbus, Bosch, Danone, Continental Mabor and IKEA). Based on this experience, we have developed an all-in-one and one passage purification module – the Nano Purifying System® (NPS®), to meet the recurrent market needs for a solution that is, at the same time, compact, capable of high throughput and efficiency, fulfilling the strict requirements of sensible environments. The innovation of NPS stands on the combination of three air treatment technologies in one single and compact module – enabled by a patented layout/geometry, which maximises treatment. The NPS® is flexible and suitable for new and retrofit applications – it can be attached to HVAC systems as an independent and complementary module or installed directly in duct. Comparing to a setup with the same purification efficiency, NPS presents a much more compact format with lower pressure drop, with potential to save operational costs in the order of 42% in energy consumption. NPS® will be a game changing for VLopes, enabling the company to scale the business by supplying the high-end market with this compact and universal pre-verified system. The HVAC market is a multibillion euro market, and VLopes sees this innovation project as a great opportunity to leverage their business, while solving key challenges within this sector. VLopes expects to achieve an accumulated turnover of €12.1 million and +120 employees by 2024, through direct sales. Thereafter, we may pursue contract manufacturing and/or licensing opportunities. The SME Instrument project will be an important vehicle to break the barriers associated to a market where the adoption of AHU is driven by track record and demonstrated efficiency.

Keywords: air handling units,air purification,hvac,indoor air quality
The Translational Cancer Faster Forward postdoctoral programme – CanFaster-ER (CanFaster-Postdoc)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Sweden
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2018, 2018)
Start date: 2020-05-01
End date: 2025-04-30
Duration (months): 60.0
Total project cost (EUR): 2206800.0
EU funding (EUR): 1103400.0
Participants: 1
Project status: SIGNED

CanFaster is a joint venture among industry, health care and academia to enhance and accelerate innovations and clinical implementation within oncology. The mission of CanFaster is to prolong and save lives of cancer patients through integrated development and commercialization/implementation of diagnostic/treatment alternatives, thus reaching the market and patient more rapidly. CanFaster will save lives of cancer patients, not for future generations, but for today´s. The CanFaster programme is enabled by an intimate collaboration between industry, health care system and academia, and will contribute to the Europe 2020 strategy, where one million new research jobs are needed to reach the Innovation Union flagship initiative. The aim of the present proposal for funding is to accelerate this process further by recruiting ERs to synergize with the already ongoing CanFaster doctoral programme. The collected track record of all partners demonstrates an impressive history of entrepreneurial spirit, state-of the art medical care but also truly world-class scientific excellence within translational cancer research. The proposed programme recruting 15 ERs, will be hosted within CREATE Health, a translational cancer research programme with broad international collaboration partners and excellent out-put for the last 12 years. Main objectives of CanFaster are (i) Increased transnational and intersectorial mobility (ii) Intersectorial improvements through intensified collaboration within oncology between academia, industry and hospital/regional health care organisations. (iii) Acceleration of innovation, attracting international investors leading to increased number of SMEs in the region and (iv) Education of a new generation of excellent multidisciplinary, entrepreneurial scientists. This is achieved through the attraction of the MSCA program for industrial partners to add-on to the EU and public national funding of the programme with financial and in-kind contribution.

Keywords: cancer research,cross disciplinary,triple helix,advanced technologies,clinical implementation,life science,intersectoral,innovation
Solar PV on the Distribution Grid: Smart Integrated Solutions of Distributed Generation based on Solar PV, Energy Storage Devices and Active Demand Management (iDistributedPV)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Germany,Spain,Spain,Germany,Italy,Lithuania,Greece,Poland,Poland
Call: Market uptake of renewable energy technologies (H2020-LCE-2017-RES-CSA, 2017)
Start date: 2017-09-01
End date: 2020-02-29
Duration (months): 30.0
Total project cost (EUR): 2706940.0
EU funding (EUR): 2706940.0
Participants: 15
Project status: CLOSED

iDistributedPV´s aim is developing affordable integrated solutions to enhance the penetration of distributed solar PV (buildings) based on the effective integration of solar PV equipment, energy storage, monitoring and controlling strategies and procedures, active demand management, smart technologies and the integration of procedures in the power distribution system according to market criteria. The project will develop the concept of “prosumer”: a player that consumes and produces electricity in his facilities (solar PV). iDistributedPV will be the EU common place for enhancing the distributed solar PV: promoters, equipment manufacturers, DSOs, energy policy experts and R&D players will work together to develop affordable solutions, and produce business and management models for these solutions. The most promising solutions will be validated according to technical and economic criteria (for every solution a cost-benefit analysis will be elaborated) in five different European real distribution grids (Greece, Lithuania, Spain, Poland and Germany) considering different climatic, regulatory and technical frameworks. The validation process will be a relevant argument to convince the power stakeholders (DSOs, equipment manufacturers, energy authorities, policy makers, etc.) about the suitability of the most effective distributed solar PV solutions such as smart electricity supply. iDistributedPV will provide technical and regulatory recommendations, mainly focused on enhancing an effective and active renewable energy contribution and effective demand management to the security and reliability of the electricity networks: evolution from a power system with a centralized electricity generation to a new one that also includes production/demand units (prosumers) based on renewable energy and smart technologies.

Keywords: prosumers,distributed solar pv,energy storage devices,effective integration with the power system,development of effective solutions,active demand management,business and management models
Launching the World’s Most Power Efficient GNSS System-On-Chip (QLX300)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

An increasing amount of IoT devices need to be tracked. All these applications rely on the Global Navigation Satellite Systems. GNSS is a system that uses satellites to provide autonomous geo-spatial positioning. Today, almost 27 billion connected devices are connected globally within the IoT. By 2025, this will multiply to over 75 billion. Qualinx has invented QLX300, the world’s most power efficient GNSS system-on-chip (SoC). QLX300 utilizes its patented discrete- time/digital RF (DRF) technology. This allows it to deliver the most power efficient GNSS solution while operating from a 1V rechargeable coin-size battery. It has the smallest form factor of less than 4 mm squared, and it offers the lowest BOM cost. It is implemented in Global Foundries’ cutting-edge 22nm FDX process, and it has an off-leakage current of less than 1uA while operating up to 105 degrees Celsius. With this capability, the solution is addressing the need for radio solutions with long battery life, driven by the portable IoT, wearable, and mobile applications in volume production. Qualinx DRF technology suits well for Bluetooth, ZigBee, Thread, GNSS, and other IoT standards demanding an ultra-low-power consumption. The serviceable available market is estimated to be 210 million units. For Europe, the IoT represents the next step towards the digitization of society and the economy, where objects and people are interconnected through communication networks and report about their status and/or the surrounding environment. In fact, the European Commission estimates the market value of the IoT in the EU to exceed €1 trillion in 2020. The IoT merges physical and virtual worlds, creating smart environments. The European Commission actively cooperates with industry, organizations and academic institutions in order to unleash the potential of the IoT technology across EU Member States and beyond . The adoption of QLX300 can help Europe run its IoT sensors on a 10th of the power currently needed.

Keywords: power efficient gnss system on chip,discrete time rf technology,digital rf technology
Biobanking and the Cyprus Human Genome Project (CY-Biobank)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Framework Partnership Agreement
Countries involved: Austria,Cyprus
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-05-04
End date: 2020-05-03
Duration (months): 60.0
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 4
Project status: CLOSED

The clinical and genetic investigations of diseases of the Cypriot population as well as eHealth are a priority of the Smart Specialization Strategy of the Cyprus government. This strategy can best be served by creating a Centre of Excellence (CoE) with two main spear heads: A contemporary Biobank and a research facility for developing the Cyprus Human Genome Project. Biobanks are organized collections of medical records and biological material of all types, aimed to support biomedical research, serving as repositories and distribution centers. Cyprus, as a Low Performing Member State, was the last country that started a Biobank, when 4 years ago we were competitively funded by the European Regional Development Fund & the Republic of Cyprus through the Cyprus Research Promotion Foundation. That project provided €2m, 0.4m of which was for creating a seed infrastructure for Biobanking. The rest was used for research in inherited kidney diseases. The money for Biobanking was too little for supporting a contemporary operation of recruiting adequate numbers of patients with complete records and promoting translational research. Here, we propose to upgrade the existing small infrastructure and turning it into a CoE with the assistance of Advanced Partners who led a similar operation Europe-wide, Prof. K. Zatloukal, coordinator of the Biobanking & BioMolecular Resources Research Infrastructure that recently became an ERIC (European Research Infrastructure Consortium) directed by Jan-Eric Litton (BBMRI-ERIC) located in Graz, Austria. The previous activity allowed us to comprehend the problems associated with patient recruitment and record collection. This can now serve as a starting point for upgrading it into a larger scale operation of European standard, aimed at leading the Cyprus Human Genome Project, part of which will be the sequencing of 1000 Cypriot genomes. This CoE will provide the prospects for innovative research and lead Cyprus into the European Research Area.

Keywords: biobank,e health,cyprus human genone project,monogenic diseases,rare diseases,kidney disorders,multifactorial conditions,new therapeutics
Disrupting the Communication between Humans and Computers - Understanding the Key Message in Simultaneous Conversations Through Voice Biometrics (PAY-ME-ATTENTION)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 1311000.0
EU funding (EUR): 917700.0
Participants: 1
Project status: CLOSED

Verbio was born as a speech technology company in 1999. We are revolutionizing communication between people and computers – allowing people to communicate naturally with machines. We are the first European company in adapting Deep Neural Networks (DNN) to speech and text, which makes us the champions in telephony and at the centre of cognitive technology. Our investment in R&D has provided us with the best results in the industry in terms of accuracy, noise robustness and voice biometrics. A patent is protecting our innovations: Natural and Secure Conversational Software. Real-time DNN and analytics will shortly be at the pinnacle. IoT-connected contact centres will be collaborating and analysing what one is saying to another. Verbio Pay-me-attention: As humans, we know to who we have to pay attention when several persons speak at the same time. Bots must also know who is the main actor of the conversation. And Verbio with Blind Source Separation (BSS) and Primary Motor Area (PMA) is giving to IoT the capacity of discernation. This is of paramount importance for mobile chatbots, autonomous cars, shopping assistants, web assistants, wearables and robots, as by 2020, 85% of interactions with clients will no longer have any human intervention. Reports forecast a market value of $7.1 trillion by 2020 for IoT, and specifically "Speech & Voice Recognition Market“ indicates US$ 11.96 Billion by 2022. Our customers (CISCO, HUAWEI, HP, SOFTBANK…) are looking for voice solutions that can be easily integrated within their applications. It is not practical to offer large up-front licensing costs and complex licensing requirements. We have a flexible cloud based SaaS model, 90% cheaper than competing services (0.02€/transaction). For the last 4 years Verbio has been growing 30% year over year in revenue. We project our growth to reach €57 million by 2023. Our specialized team is expected to grow dynamically while we expand our international presence (EU, US and LATAM).

Keywords: speech technology,deep natural network,blind source separation,voice recognition,voice biometrics,security,continuous speech recognition,natural language understanding,text to speech
House Poetics. An 'assemblage' approach to the production and transmission of value in Bronze Age Crete. (HousePoetics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

The Project explores the fundamental social question of the creation of value, by investigating House Societies in Bronze Age Crete (3100-1200 BC). Houses are understood as intergenerational, locus-bound social groups, holding an estate of material and symbolic wealth, transmitted along a real or imaginary line, legitimized by kinship or affinity, or both. Because of their distinct focus on the creation and transmission of value, Houses are an ideal framework for answering this research question, but their longevity makes it difficult to explain change. By fusing Houses with the philosophical and sociological premises of Assemblage theory, which argues that social entities are not fixed but constituted by relationships between humans, non-humans and materials that can territorialize and deterritorialize value, the project creates a new social ontology which perceives Houses in a constant state of becoming, continuously affecting and being affected by the changing social world they inhabit. The methodological advantage of this interdisciplinary model, combining philosophical, sociological, archaeological and scientific perspectives, will be demonstrated empirically through the integrated use of GIS spatial analysis and material culture analysis, in a series of case studies (selected on the basis of availability of good contextual information for primary data and a large corpus of published evidence) targeting three strategic scales of House formation and interaction: a single site (Petras), its regional context (East Crete) and their broader geopolitical networks (the Aegean and the East Mediterranean). Using GIS to explore Houses as Assemblages will offer an original integration of spatial, material and social scales, which can revitalize our understanding of past societies and transform the study of social relations in general.

Keywords: house societies,assemblage theory,structural anthropology,affect,material culture,bronze age crete,deleuze
Clonal Deletion versus Clonal Diversion: Footprints of Self-Tolerance in the T Cell Repertoire (TOLERANCE FOOTPRINT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2022-09-30
Duration (months): 60.0
Total project cost (EUR): 2414500.0
EU funding (EUR): 2414500.0
Participants: 1
Project status: CLOSED

Self-tolerance is a key feature of the immune system; its failure causes autoimmune diseases such as Multiple Sclerosis or Type-1-Diabetes. Remarkably, T cell tolerance operates via two fundamentally different mechanisms: potentially dangerous cells are either eliminated (clonal deletion) or re-programmed to differentiate into regulatory T (Treg) cells (clonal diversion). Paradoxically, both tolerance modes can ensue from self-antigen-encounter in the thymus, and the parameters specifying these opposing cell-fates remain poorly understood. Moreover, the relative contribution of clonal deletion versus clonal diversion to tolerance at the level of diverse immune cell repertoires has not been determined. In particular, the paucity of antigen-specific cells is a major experimental obstacle to unravelling to what extent cells with shared autoreactive specificity, yet different T cell receptors (TCRs), are subject to either mode of tolerance. Breakthroughs in visualizing minute cohorts of antigen-specific cells, characterizing the TCRs on individual cells and large-scale TCR sequencing now provide a unique opportunity to tackle these challenging questions. Based upon my expertise in thymus biology and T cell selection, I will exploit these technological advances to reveal where and how tolerance either generates ‘holes’ in the repertoire or diverts cells into a ‘benign’ sub-repertoire. The main objectives are (i) to identify and classify deleted or diverted TCR-entities through comparing ‘uncensored’ and ‘censored’ repertoires in the absence or presence of a disease-relevant autoantigen and (ii) to identify TCR intrinsic features as well as T cell extrinsic determinants that specify clonal deletion versus clonal diversion. The proposed research elucidates a fundamental aspect of vertebrate immunology, but also has major implications regarding the therapeutic promise of harnessing endogenous, antigen-specific Treg cells in autoimmunity.

Keywords: t cell tolerance,t cell repertoire,thymus,clonal deletion,regulatory t cell