Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Circularity and Remanufacturing-Enabling DIgital Twins (CREDIT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Spain,Ireland,Türkiye,Slovenia,Greece,Germany
Call: Factory-level and value chain approaches for remanufacturing (Made in Europe Partnership) (IA) (HORIZON-CL4-2023-TWIN-TRANSITION-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 6277087.5
EU funding (EUR): 5586185.26
Participants: 13
Project status: SIGNED

The CREDIT project will address current challenges in circular remanufacturing by adopting a human-centred innovation approach, focusing on the digitalisation of assets (A), creating multi-layered Digital Twins (B), and developing an open-source-based distributed ICT platform (C), allowing seamless data management and complex DT implementation. Additionally, a range of remanufacturing-enabling digital services (D), including AI-based decision support systems, DLT-based traceability and quality control, predictive maintenance, and general support tools for remanufacturing operations, such as Augmented Reality, will be integrated. Alongside these technologies and tools, a comprehensive upskilling and education methodology (E) will be developed to ensure the appropriate level of maturity at the factory site. Five diverse business cases in the white goods, telecommunications, aerospace, toolmaking and automotive sectors have been designed based on their relevance and potential for broad impact. These use cases will be co-created with stakeholders in line with the social innovation methodology to ensure that the specific objectives and technologies are aligned with end users' needs. By providing an operational environment, these use cases will serve as the foundation for achieving the final TRL7 and demonstrating the platform's adaptability and potential for deployment in various industrial sectors. This will be consolidated through a scaled replicability study. The project's far-reaching impact will touch a wide set of target groups, leading to a more sustainable, efficient, and socially responsible future for the manufacturing industry. CREDIT will generate economic benefits such as increased efficiency, reduced production costs, and enhanced competitiveness while addressing environmental concerns by reducing waste, lowering carbon emissions, and minimizing raw material consumption, in line with the EU’s green manufacturing and sustainability targets.

Keywords: remanufacturing digital twins icp platform human centred innovation
DataSpace, DataShare 2.0 (DS2)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Israel,Spain,Finland,Greece,Romania,United Kingdom,Estonia,Slovenia,Germany
Call: Integration of data life cycle, architectures and standards for complex data cycles and/or human factors, language (AI, data and robotics partnership) (RIA) (HORIZON-CL4-2023-DATA-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 7612406.25
EU funding (EUR): 7612406.25
Participants: 18
Project status: SIGNED

DS2 draws researchers and practitioners from diverse disciplines to secure that complex lifecycles of inter-sector data sharing, aggregation and provenance take place in a human-centric and trusted way, with common structures, exportability and insight, whilst protecting the sovereign rights of data owners and complying with European data regulations. DS2 provides a modular software infrastructure to connect data sources (Data Spaces/data silos/data lakes) together for the purpose of cross-sector data sharing. Once connected, data consumers and data providers will be able to structure and execute efficient complex data lifecycles that respect the technical and governance related requirements of the participating data sources. It will do this via an IDT (Intersector DataSpace Toolkit) which is deployed at each data source/space and network connected to any other IDT-enabled data source. The IDT Toolkit is composed of a Broker which manages the fail-safe network operation with no central point of control. Plugged into this is a set of modules for the execution of complex data lifecycles, e.g. filtering, labelling, both automated and catering for where human-in-the loop is required. DS2 will pilot and evaluate its technology using 3 well-defined, inter-sector use cases, (City Scape, Green Deal, Precision Agriculture). The DS2 solution enhances and accelerates the shift towards the data economy by addressing the challenges, pain-points, and requirements with respect to the execution of complex data lifecycle. Data consumers and data providers can now orchestrate, manage and securely execute complex data lifecycles to realize cross-sectorial data driven applications.

Keywords: data space,data portability,data sovereignty,human in the loop,interoperability
Chimeric Antigen Receptor (CAR) T Cell Therapy For Solid Tumors (CAR-T-uning)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-09-01
End date: 2024-02-29
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

CAR-T(uning) will assess the technical and commercial feasibility of an improved and broadly applicable chimeric antigen receptor T-cell (CAR-T) approach based on a novel implemented mechanism of action. There is an urgent need for more effective treatment strategies against cancer, which remains the leading cause of death worldwide. Immuno-oncology regimens such as, immune checkpoint blockade therapy (ICT) and CAR-T therapy emerged as powerful tools in cancer treatment, however, in the majority of patients these fail to achieve long-lasting therapy response. Further, they remain costly and applicable to a limited range of cancer types. Specifically, CAR-T therapy faces two unresolved challenges: 1) limited therapy persistence; 2) tumor-induced immunosuppression. Consequently, no CAR-T therapy against solid tumor cancers has reached the market. Prof. Gottfried Baier has uncovered that inhibition of orphan nuclear receptor NR2F6, a downstream target of T cell antigen receptor signaling intermediate PKCθ, overcomes these shortcomings in a two-fold manner: 1) increased therapy persistence to improve its long-lasting effects; 2) reduced immunosuppression at the tumor site to improve immune response. Within this ERC PoC, first we will technically validate this approach using in vivo mouse and ex vivo patient-derived tumor models. We will focus on NSCLC as first indication, as it is one of the most-difficult to treat solid cancers with high mortality rate and disease burden. Subsequently, commercial feasibility will be determined by verifying IP position and strategy, performing in-depth market and competitor analyses, and finally consolidating these into a business plan to establish the best path to commercialization. Successful commercialization of CAR-T(uning) would reduce the socioeconomic burden of NSCLC, extending and improving patient lives, and enable the development of long-lasting, (cost-)effective CAR-T therapies applicable to a greater range of cancer types.
ADVANCED BIO-BASED REFINERY INTERMEDIATES (ABATE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Greece,Czechia,Germany,Denmark,United Kingdom,Belgium,Sweden,France,Italy,Spain
Call: Demonstration of improved intermediate renewable energy carrier technologies for transport fuels (HORIZON-CL5-2024-D3-01, 2024)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 10226791.53
EU funding (EUR): 9057774.78
Participants: 14
Project status: SIGNED

The ABATE project aims to upscale and demonstrate in an industrial relevant scale a complete sustainable value chain based on the integration of thermochemical and biochemical technologies for the valorization of lignocellulosic residual and non-food/feed biomass into cost-competitive, carbon-neutral Advanced Bio-based intermediATEs (ABATEs) to directly substitute fossil hydrocarbons in conventional oil refineries. The technology was validated in TRL5 via a Horizon 2020 project (BioMates), which involved a two-step valorization of lignocellulosic biomass. In ABATE, residual lignocellulosic biomass is firstly converted into fast pyrolysis bio-oil (FPBO) and bio-char. CO2 from the FPBO production will be sequestrated and converted into methanol, enabling the mitigation of GHG emissions of the pyrolysis step as well as side-production of green methanol. Secondly, the FPBO is stabilized into a high-quality advanced bio-based intermediate, which can be directly fed in conventional refinery plants, enabling the direct decarbonization of the refining sector as well as of the transportation fuels and chemicals. The stabilization will be performed via a single hydroprocessing step which incorporates several innovation systems and designs (i.e. a novel catalytic system abiding to FPBO acidity and solids content, optimal energy integration, as well as its integration with green H2 and a biochemical CCU unit). The ABATE end use will be demonstrated via co-feeding with refinery intermediates, rendering hybrid marine and aviation transport fuels, as well as feasibility and business plans. ABATE technology may satisfy over 55% and 5% of the EU renewable marine and aviation fuels demand by 2035, respectively. The ABATE project aims to scale-up and intensify the technology to reach 90%-120% GHG emission reduction (according to RED) in industrial scale by optimized processes and their integration with RES components (i.e. green H2) minimizing the use of fossil energy inputs.

Keywords: sustainable advanced biofuels,bio intermediates,jet fuel,marine fuel,fast pyrolysis,hydrodeoxygenation,stabilisation,refinery integration,decarbonisation,demonstration,carbon neutral fuel,ccu
The Ottoman Core: A Spatial Exploration of the Emergence of Ottoman Governance Practices (OTTOMANCORE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Austria,Bulgaria,Türkiye
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 1999903.0
EU funding (EUR): 1999903.0
Participants: 3
Project status: SIGNED

The OTTOMANCORE project seeks to redefine the understanding of how the Ottoman Empire was governed during its much-debated formative period (14th–16th centuries). It challenges the prevalent statist narrative in historiography that envisages Ottoman rulership as a top-down, preordained construct and proposes a novel regional perspective to examine governance practices from a spatially aware and actor-centered viewpoint. Leveraging a robust analytical foundation that assimilates information from a diverse array of Ottoman and Central European narrative and documentary sources, as well as archaeological data, the project explores the local mechanisms and socio-economic grounding of Ottoman governance. OTTOMANCORE proposes to ‘deconstruct’ the essential constituents of governance and ‘deanonymize’ numerous provincial stakeholders to unearth the grassroots of Ottoman rulership. The project is structured into three interlocking modules. The first is dedicated to developing innovative Handwritten Text Recognition (HTR) models and automated data extraction from Ottoman sources. The second module delves into a complex geospatial analysis of diverse data, probing the local governance practices, landholding patterns, and socio-economic dynamics by examining several interrelated components: i) land regime; ii) settlement network; iii) population geography; iv) connectivity and communication; v) revenue distribution. The final module aims to synthesize these findings into a coherent spatial narrative, rearticulating the history of Ottoman governance from a regional standpoint. OTTOMANCORE’s approach, blending history with cutting-edge technology, pushes the boundaries of Ottoman historiography and sets a new standard for empirical research. By challenging existing narratives and introducing novel methodologies, it holds the potential to foster a more nuanced appreciation of Ottoman governance and reshape our understanding of the ruling practices of pre-modern empires.

Keywords: ottoman empire balkans land ownership settlement geography landscape archaeology population geography connectivity taxation htr historical gis spatial analysis
High throughtput electrophysiological measurements coupled with transcriptomics to reveal cellular dysfunction in type 2 diabetes (T2D-EOMICS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 2
Project status: CLOSED

In this project, I will develop methods to simultaneously measure transcriptomes with single-cell resolution and perform high-throughput functional measurements of individual pancreatic islet cells. I will focus on β- and α-cells which regulate glucose levels by secreting the two main glucoregulatory hormones -insulin and glucagon- and whose dysfunction is associated with diabetes. The islet is a highly heterogenous mini-organ, making it an ideal tissue to study the relationship between molecular and functional heterogeneity. It has been recently developed the use of patch-clamp electrophysiology and single-cell RNA sequencing (patch-seq) using whole-cell electrophysiology. In this work, I will combine high-density microelectrode array technology (HD-MEA) and transcriptomic methods to identify changes that lead to dysfunctional cellular states in type 2 diabetes. To do so, I will build a cell cherry-picking system to perform single-cell RNA sequencing after electrophysiological measurements in the same islet cell. Then I will use this system to investigate subpopulations of α- and β-cells that have been previously identified in human islets from donors with type 2 diabetes using transcriptomic methods, but whose implications in cell and tissue function are yet unclear.

Keywords: electrophysiology,diabetes,single cell,islet cells
Leading-edge cooperative advances towards the next generation of concentrated solar power (CSP) technology (COOPERANT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Switzerland,Portugal,United Kingdom
Call: Next generation of renewable energy technologies (HORIZON-CL5-2024-D3-01, 2024)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 2999500.0
EU funding (EUR): 2999500.0
Participants: 7
Project status: SIGNED

COOPERANT is at the forefront of advancing the next generation of Concentrated Solar Power (CSP) technologies by tackling typical limitations of conventional CSP facilities, such as operation at high temperatures, dispatchability, cost-effectiveness and sustainability. COOPERANT's innovations are paving the way for the uninterrupted generation of green solar power that is both dispatchable and economically viable, breaking the dependency on solar radiation. Working at high temperatures (~1000ºC) is crucial to increase efficiency and cost-effectiveness; however, harsh operating conditions present significant challenges in terms of material availability, corrosion, system design and performance limitations. In alignment with the SET-Plan for CSP, the proposal incorporates three cutting-edge solutions at technological, digital and transference levels, that synergistically cooperate to address them: -COOPERANT CSP-TES system: a groundbreaking concept showcasing a high-performance volumetric solar receiver with custom-designed cellular morphology coupled with a hybrid packed-bed Thermal Energy Storage (TES) system. Enhanced phase-change materials and solid-state mixtures will be formulated and characterised to serve as high-temperature storage mediums. Heat transfer enhancement and containment techniques will be applied to ensure operation safety and long-lasting durability. -COOPERANT-AI TOOL: including real-time monitoring, reinforced learning-based control, scalability and replicability features. A holistic orchestration by sophisticated artificial intelligence digital tools to assist with feasibility, replicability, and scalability paths towards commercialisation. -COOPERANT-TRANSFER: a knowledge transference programme with a multi-stakeholder approach, engaging closely with the industrial sphere through the Stakeholder Replicability Board (SRB), enlisting key partners focused on dispatchable clean energy, solar fuels generation and industrial applications.

Keywords: concentrated solar power thermal energy storage,high temperature,efficient power generation,hybrid packed bed system renewable energy sources integration sustainability and circularity
Initiative for european Semiconductor-based Large-scale Quantum computer (QLSI2)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Cluster 4 other
Destination: Other Digital, Industry and Space destinations
Action type: Research and Innovation actions
Countries involved: France,Belgium,Netherlands,Germany,Finland,Poland,Austria,Hungary,Israel
Call: Developing large-scale quantum Computing platform technologies (SGA) (HORIZON-CL4-2024-QUANTUM-01-SGA, 2024)
Start date: 2024-06-01
End date: 2027-11-30
Duration (months): 42.0
Total project cost (EUR): 24974713.5
EU funding (EUR): 24974713.5
Participants: 24
Project status: SIGNED

QLSI2 brings together the expertise of 23 partners from 9 countries with the ambition to demonstrate a cloud-accessible 200-qubit semiconductor-based quantum computer by the end of 2027. In addition, the consortium aims to demonstrate the implementation of meaningful use cases on this demonstrator. The QLSI2 project will leverage the expertise of key European players (RTOs, academic laboratories, start-ups and large companies) in complementary fields of quantum technologies, from hardware to software, to define and implement a roadmap towards such an ambitious goal. The roadmap will extend its vision to the entire value chain, including the supply chain. Particular attention will be paid to the industrialisability of the proposed solution in order to keep Europe at the forefront of the race for quantum supremacy for a long time to come. The roadmap will be implemented considering both heterostructure-based and FD-SOI-based routes. In addition, and following these two routes, QLSI2 aims to advance both technology and manufacturing readiness to a level high enough to meet Europe's ambitions for the industrialisation of quantum technologies, with a particular focus on scalability. With these overall objectives and expected outcomes, QLSI2 will have a significant impact on the field towards LSQ.

Keywords: quantum technologies semiconductor based qubits scalability industrialization quantum computing quantum computer quantum advantage nisq cloud accessibility
A novel test trio to detect peptide biomarkers in saliva and blood for enhanced diagnosis and management of Alzheimer's Disease (FluiDx-AD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Norway,Netherlands,Italy,Spain,Finland,Luxembourg
Call: Validation of fluid-derived biomarkers for the prediction and prevention of brain disorders (HORIZON-HLTH-2024-DISEASE-03-two-stage, 2024)
Start date: 2024-11-01
End date: 2028-04-30
Duration (months): 42.0
Total project cost (EUR): 9489943.49
EU funding (EUR): 7699219.38
Participants: 10
Project status: SIGNED

FluiDx-AD aims to transform Alzheimer’s disease (AD) diagnosis and prepare the EU healthcare systems for the emergence of new AD therapies, with a 1st-in-class trio of In Vitro Diagnostics tests. FluiDx-AD tests detect a unique and proprietary suite of biomarkers in simple bodily fluids (saliva, plasma/blood), towards widespread, patient-empowering, and all-inclusive AD diagnosis, at least as accurate as the costly and invasive procedures currently in place. FluiDx-AD tests have the potential to shorten AD diagnosis by 7-15 years, by detecting biomarkers that mark the onset of AD years before the appearance of clinical symptoms. Earlier diagnosis means earlier access to preventive interventions, which are now more effective thanks to next-generation immunotherapies. The clinical use of these new drugs is not consensual though, because of the severe side-effects they inflict in some patients. FluiDx-AD tests offer a pioneering tool to stratify and monitor patients eligible for these drugs, towards reducing their associated risk and accelerating their regulatory clearance in the EU. FluiDx-AD tests are thus devised to work complementarily and sequentially, covering the full AD diagnostic journey (from population-wide screenings to confirmatory diagnosis, and downstream patient stratification and monitoring), tackling key challenges of early AD diagnosis and AD prevention with new drugs, while also paving the way for the development of new therapies by streamlining patient selection and appraisal in clinical trials. FluiDx-AD brings together a team of highly motivated, committed, and reputed entrepreneurs, clinicians, and scientists from biotechs, hospitals, academic centres, and patient organizations across the EU. Leveraging our unique blend of trans-disciplinary/-sectoral expertise and access to advanced technologies and infrastructures, we join forces to realize the vision of a new era of AD clinical management for the benefit of millions of patients globally.

Keywords: diagnosis,biomarkers,immunotherapy stratification