Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mechanisms of Immune Receptor Diversification in Cereals (MIREDI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-09-01
End date: 2022-08-31
Duration (months): 60.0
Total project cost (EUR): 1499997.0
EU funding (EUR): 882899.0
Participants: 2
Project status: CLOSED

The plant immune system is innate – it is encoded in the germline. In natural pathosystems, plants efficiently deploy hundreds of immune receptors to detect and disarm rapidly evolving pathogens including viruses, bacteria, nematodes, insects, fungi and oomycetes. Exactly how such receptor diversity can evolve is an elusive question with important practical ramifications. A central class of plant immune receptors, called Nucleotide Binding Leucine Rich Repeats proteins (NLR), has been implicated in recognition of vastly diverse pathogen-derived effector molecules. An emerging paradigm of receptor diversification in plant genomes involves new gene fusions of receptors with host proteins that are normally targeted by pathogen effectors. Such fusion receptors ‘bait’ pathogens and their integrated domains are thought to function as ‘decoys’ or ‘sensors’ that mediate pathogen recognition. I have recently demonstrated that the mechanism of generating new receptors through gene fusions originated at least 500 million years ago in mosses and is common to all flowering plants. Here, I propose to decode the mechanisms of plant immune receptor diversification by gene fusions by studying diversity and functions of immune receptors in grasses, a young highly diversified plant family that includes the three most important crops: maize, rice and wheat. My specific aims are to: 1) Determine rates of receptor diversification within and across genomes 2) Dissect the mechanisms of receptor regulation and receptor activation 3) Generate novel plant immune receptors based on the NLR platform prone to fusions. In this MIREDI research programme, I will combine state of the art sequencing techniques and bioinformatics, molecular biology and novel reverse genetics techniques to study how plant immune system co-evolves with pathogens and what limits diversification of immunity in domesticated crops.

Keywords: plant disease resistance,immune receptors,pathogens,pathogen effectors
User Engagement for Large Scale Pilots in the Internet of Things (U4IoT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Switzerland,Belgium,Belgium,Switzerland,Serbia,Sweden,Netherlands
Call: IoT Horizontal activities (H2020-IOT-2016, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 1878625.0
EU funding (EUR): 998625.0
Participants: 8
Project status: CLOSED

End-user and societal acceptance is critical to the success of the IoT large scale pilots. U4IoT combines complementary RRI-SSH expertise encompassing social and economic sciences, communication, crowdsourcing, living labs, co-creative workshops, meetups, and personal data protection to actively engage end-users and citizens in the large scale pilots. It will: • Develop toolkit for LSPs end-user engagement and adoption, including online resources, privacy-compliant crowdsourcing tools, guidelines and an innovative privacy game for personal data protection risk assessment and awareness, online training modules. • Direct Support to mobilize end-user engagement with co-creative workshops and meetups, trainings, Living Labs support, and an online pool of experts to address LSPs specific questions. • Analyse societal, ethical and ecological issues and adoption barriers related to the pilots with end-users and make recommendations for tackling IoT adoption barriers, including educational needs and sustainability models for LSPs and future IoT pilots’ deployment in Europe. • Support communication, knowledge sharing and dissemination with an online portal and interactive knowledge base gathering the lessons learned, FAQ, tools, solutions and end-user feedbacks. The U4IoT platform will support IoT take-up in Europe by better aligning it with end-user and societal expectations, mutualizing information and learning experiences, and improving communication with the public,- enabling Europe to take the lead in IoT user (and market) adoption. U4IoT will work in close cooperation with the other CSA, AIOTI and the IoT Forum who will maintain the platform after the end of the project to continue serving the European IoT community.

Keywords: end user engagement,iot adoption,living labs
Three dimensional breast cancer models for X-ray Imaging research (MaXIMA)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Italy,Belgium,Bulgaria
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 998050.0
EU funding (EUR): 998050.0
Participants: 3
Project status: CLOSED

Nowadays, the development of realistic three-dimensional computational and physical models of breast tumours with irregular shapes is an urgent requirement. The availability of such models is a powerful instrument in the hands of engineers, physicians and physicists to be used in the development of new technologies for precise definition of the boundaries of these cancers. Scientists from the biomedical engineering unit at Technical University of Varna are present in this area both at modelling and simulation of computational breast phantoms and x-ray breast imaging techniques. To advance in their research aims and therefore to raise the profile of their researchers and S&T capacity of the host organisation, collaborations with top research institutions from complementary areas of expertise are a requirement. In addition, the touch with world experts in this area is needed in order to have local researchers at host informed about the most current findings in the field and to discuss specific scientific issues that otherwise will not have such a chance. The main objective of this action is to increase the research and innovation capacity of the host organisation in the field of computational modelling of breast tumours (including cancers with irregular shape) and their use in studies of advanced x-ray breast imaging techniques such as breast tomosynthesis and phase contrast imaging. For this purpose, the project will establish a close and sustainable collaboration platform, in the form of a network of three scientific groups working in the specific domain of modelling and simulations dedicated for studies of x-ray breast imaging techniques. The network will aim to (a) increase the research and innovation capacity of the host organisation, (b) integrate results of ongoing research, (c) facilitate progress beyond the actual individual possibilities, (d) advance the research activities of all partners through a joint and mutually fruitful collaboration.

Keywords: advancement in x ray breast imaging research,advancement in modelling tumours with irregular shapes,advancement in use of 3d printing for physical phantoms,research excellence
Science in the City: Building Participatory Urban Learning Community Hubs through Research and Activation (PULCHRA)

Framework: Horizon 2020 — Science with and for Society
Programme: Encourage citizens to engage in science through formal and informal science education, and promote the diffusion of science-based activities, namely in science centres and through other appropriate channels
Action type: Coordination and support actions
Countries involved: Germany,Italy,Ireland,Cyprus,Sweden,Greece,Romania,Poland,Greece,Latvia,Czechia,Czechia
Call: Open schooling and collaboration on science education (H2020-SwafS-2018-2-two-stage, 2018)
Start date: 2019-09-01
End date: 2022-12-31
Duration (months): 40.0
Total project cost (EUR): 1489925.0
EU funding (EUR): 1489925.0
Participants: 12
Project status: CLOSED

The PULCHRA* project will explore the open schooling concept in the theme "Cities as urban ecosystems”, in view of creating new partnerships in local communities to foster science education for all citizens. Schools, in cooperation with other stakeholders will become agent of community well-being, taken that the theme to be explored encompasses the natural environment, the built environment and the socio-economic environment in cities. This is of great importance, taken that the urgency of cities to be approached as urban ecosystems is underestimated and limitedly linked to science education for all citizens. The methodology is based on pilot themes (termed as City Challenges) which create know-how, built trust in the science approach based on own experience, facilitate skilled use of tools and support community building as they are based upon the identity of the communities in which they take place. A City Challenges (technological) Platform is developed to bridge partners, schools and stakeholders; mixed Science Teams and students acting as City Reporters will explore and disseminate the City Challenges respectively. Our approach is situated in the own living environment. Engaging in environmental education has a direct impact upon the community and the personal lives of the participants. The benefit of international cooperation of the EU member states becomes obvious at the community level. The consortium is coherent and brings complementary expertise, whereas the project is supported by a wide variety of stakeholders in the participating countries, a fact which is considered an asset of the project and shows its replication potential. Finally the pilot themes to be explored within the project exhibit richness in science as they take note of several scientific fields as related to cities as urban ecosystems, they are supported by technology, bring in innovation and are directly linked to SDGs and the European policies for cities. *beautiful in Latin

Keywords: urban ecosystems,city challenges,knowledge triangle,innovation,international cooperation
What makes a successfull pathogen? Understanding the impact of cell-to-cell heterogeneity in chromatin structure on infection and adaptation (Cell2Cell)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Israel,Germany,Germany,Sweden,Switzerland,Türkiye,Hungary,France,Netherlands,United Kingdom,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-11-01
End date: 2024-01-31
Duration (months): 51.0
Total project cost (EUR): 3889769.04
EU funding (EUR): 3889769.04
Participants: 12
Project status: SIGNED

Infectious diseases kill millions of people worldwide every year. Decades of research have revealed important insights into the molecular mechanisms pathogens employ to establish lasting infections, yet little is known about what renders individual pathogens within a microbial population more successful at establishing an infection than others. Recent advances in single-cell technologies have started to revolutionize modern biology, unveiling an enormous degree of cell-to-cell heterogeneity. Often, phenotypic variability is not caused by genetic changes in the DNA sequence, but by epigenetic changes in the structural organization of DNA called chromatin. In multicellular organisms, this epigenetic plasticity plays a key role in developmental processes and cancer. In unicellular pathogens, cell-to-cell heterogeneity is hypothesized to promote the establishment of infections by allowing the pathogen to adapt to changing environments or evade the host immune response. To decrease the burden of infectious diseases, it is therefore, necessary to better understand how infections are enabled by cellular heterogeneity at the chromatin level of the pathogen. Several limitations have previously challenged this endeavor, including small genome size (i.e. low signal-to-noise) and the lack of knowledge of how chromatin is organized in pathogens. Cell2Cell proposes to overcome these barriers by bringing together (1) experts in pathogen biology; (2) the use of unicellular yeast species to serve as chromatin models; (3) single-cell technologies; (4) bioinformatics tools. Using state of the art technologies, we will train early stage researchers to identify the molecular mechanisms that control cell-to-cell heterogeneity in pathogens. The proposed research will contribute to the elucidation of how heterogeneity affects the outcome of diseases and give rise to highly skilled scientists that are well prepared to face the demands of modern genomics research in academia and industry.

Keywords: single cell,pathogens,protozoan parasites,yeast,heterogeneity,chromatin,gene expression,molecular biology,next generation sequencing
The RowP system by Quiske Ltd is a game changing rowing technique measuring and coaching system for any level of rowers or crew both outdoor and indoors. (Quiske RowP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Quiske is a Finnish sports technology startup company. The Quiske team have developed an advanced yet affordable and simple to use RowP product which helps rowers improve their technique. The RowP system gives instant feedback and post-training analytics for on water as well as indoor rowing. The pilot product was first launched in the summer and has since generated interest worldwide. Quiske seeks funding to create a business plan commercialize the product and to reach new markets. The RowP product consists of a lightweight and affordable multifunctional pod which can measure handle or seat speeds and the instant feedback can be viewed on any smartphone display. Advanced algorithms allow analyzing and even comparing the technique of rowers with each other in the RowP cloud service. We are bringing the advanced rowing performance measurements not only to elite competitive rowers but also to the much higher volume indoor rowing market to help anyone learn to row correctly. The RowP system also includes a Virtual Coach to help indoor rowers improve their performance. Indoor rowing is practiced by 100s of millions of people in gyms across the world. However, most people do it with bad technique which doesn’t help improve their fitness optimally. In addition to the innovative Virtual Coach we we will also bring Augmented Reality to make the indoor rowing experience better. The RowP App will be gamified to make it more fun to use and to include sharing of results to social media. Based on request from customers we will also build an iOS version of the App. The feasibility study will result in a business plan to roll out the RowP product and analytics platform globally and to collect and technically validate the features for the commercial RowP product, that our first pilot customers have asked for.

Keywords: rowing,augmented reality,performance measurement,technique measurement,sport analytics,analytics,sensor
Oncolytic viruses for the treatment of pediatric brain tumors: An integrated clinical and lab approach (ViroPedTher)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-03-01
End date: 2024-08-31
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The overreaching goal of my lab is to improve the prognosis of patients with high-risk pediatric brain tumors. To this end, I propose to integrate clinical and lab-based research to develop tumor-targeted oncolytic adenoviruses with the capacity to elicit a therapeutic immune response in those tumors. Our research will use novel and relevant models to accomplish the experimental aims. We have previously worked with Delta-24-RGD (DNX-2401) a replication-competent adenovirus that has been translated to the clinical scenario. In 2017, the first clinical trial phase I with DNX-2401 for newly diagnosed Diffuse Intrinsic Pontine Gliomas (DIPG; a lethal pediatric brain tumor) opened propelled by my team. Preliminary results from the first trials revealed that the intratumoral injection of the virus instigated an initial phase of oncolysis followed by a delayed inflammatory response that ultimately resulted in complete regression in a subset of the patients without associated toxicities. I hypothesized that enhancement of the immune component of the DNX-2401-based therapy will result in the complete regression of the vast majority of pediatric brain tumors. In our specific approach, we propose to understand the immune microenvironment of DIPGs and the response to viral therapy in the context of the trial. Moreover, that knowledge will leverage the design of Delta-24-based adenoviruses to recruit lymphocytes to the tumor with the competence of different type of ligands to activate the tumor infiltrating lymphocytes. I expect that this combinatorial innovative treatment will efficiently challenge the profound and inherent tumor immunosuppression and, in turn, will elicit a robust anti-tumor immune response resulting in the significant improvement of the prognosis and quality of life of patients with pediatric brain tumors. This project has the potential to produce a vertical advance in the field of pediatric oncology.

Keywords: pediatric brain tumors,oncolytic virus,clinical trial,adenovirus,immune response,biomarkers
Support to the Vice-Presidents of the ERC Scientific Council 2014 (ERCSC-VPRES-SUP2014)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: ERC other
Action type: Coordination and support actions
Countries involved: Switzerland
Call: European Research Council (H2020-Adhoc-2014-20, 2014)
Start date: 2014-01-01
End date: 2014-12-31
Duration (months): 12.0
Total project cost (EUR): 258500.0
EU funding (EUR): 258500.0
Participants: 1
Project status: CLOSED

The proposed Action will provide the necessary support to the Vice-Presidents of the European Research Council Scientific Council (ERC ScC) to achieve key milestones and deliverables of the ScC, which are required in the first year of implementation under the Horizon 2020 framework programme. Under the Horizon 2020 programme, the Commission has established the European Research Council providing a competitive funding mechanism for investigator-driven frontier research on European level. One of the key structural components of the ERC is the Scientific Council consisting of 22 eminent researchers, representative of a large range of disciplines and institutional backgrounds. The ERC ScC independently establishes and oversees the ERC's scientific management and the implementation of the Work Programme, including the peer review and the selection of peer reviewers. The three Vice-Presidents of the ERCâ€™s ScC, in their diverse responsibilities which include the achievement of efficient and effective functioning of the ScC, its integrated operation together with the ERC Executive Agency (ERCEA), and effective interfacing with the scientific community, other funding agencies and the political institutions of the European Union. The project will provide administrative and research support ranging from secretarial tasks to assistance in developing policy papers related to the work of the Vice-Presidents of the ERC ScC for a period of one year. The potential impact of the project will be to ensure an efficient and well-managed operation of the ERC ScC. By providing high-level local support for the Vice-Presidents, the project will complement the activities of and allow efficient interfacing with the ERCEA. The proposed support is required as the duties of the Vice-Presidents demand a considerable part of their time. Overall, the project is expected to contribute significantly to the implementation of the ERC under Horizon 2020.

Keywords: erc scientific council
Local and Nonlocal Free Boundary Problems (LNLFB-Problems)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

A wide class of physical phenomena can be mathematically formalized as Free Boundary (FB) problems, usually described by a set of Partial Differential Equations (PDEs) that exhibit also some unknown interfaces (the FB). The main goal is to describe as precisely as possible both the solution to the PDEs and the properties of the FB, an issue of significant theoretical complexity. In this project the Experienced Researcher (ER) presents different FB problems, depending on their nature: local/nonlocal and elliptic/parabolic. The first part is devoted to elliptic problems, with two objectives: the first one is to prove some quantitative regularity estimates for solutions to a class of elliptic semilinear equations related to Bernoulli one-phase type problems (local/nonlocal setting), while the second is to investigate the regularity/structure of the FB in a general nonlocal obstacle problem. Also the second part has two objectives (parabolic framework). The ER intends to study some nonlocal parabolic Bernoulli one-phase type problems. In this framework, the whole theory must be developed: the ER plans to study the existence of suitable weak solutions as well as their optimal regularity and the regularity/structure of the FB. The project contains innovative aspects, new techniques, and possesses a large number of applications to Physics, Engineering and Natural Sciences. The expected results are of great quality and will have significative impact in the PDEs community.

Keywords: free boundary problems,nonlocal operators,elliptic and parabolic equations