Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Functional Organization of Immunity by Lymphoid Stromal Cells (Stroma.Org)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-01
End date: 2022-06-30
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

The immune system is faced with a substantial challenge – it must provide rapid, tailored immunity to the host without a priori knowledge of when, where and which pathogen will invade, and at the same avoid damage to self. Recent evidence, including my own prior work, suggests that the anatomical organization of the lymphoid organ in which the immune response is initiated determines the quality and quantity of the response. Lymph nodes (LNs) are supported by a scaffold of mesenchyme-derived stromal cells (SCs) that not only provides gross anatomical support, but also produces critical survival factors and localization/movement guidance cues to antigen-presenting cells and antigen-responsive lymphocytes during the initiation of the immune response. Despite the now emerging role of SCs in immune responsiveness, it is unclear at a molecular and cellular level how these cells support the fine-grained spatial and temporal requirements for robust immunity. Here, using novel single cell datasets, advanced highly-multiplex immunofluorescence imaging, spatial statistics, genetic targeting and in house-developed tools to track the development of immune responses, I aim to 1) create a comprehensive single cell atlas of LN organization in homeostasis, 2) unravel the rules of lymphoid SC specification and organizer function, 3) determine the impact of LN architecture on protective immunity, and 4) determine how such organization is altered in asthma, a highly prevalent chronic inflammatory airway, since alterations in SC-immune cell intercellular communication could explain increased immunity to harmless allergens, in the face of reduce immunity to viral infection and vaccination. By combining my qualifications in SC biology and LN organization with the expertise of the host lab in lung immunopathology, I have created an ambitious work plan that will serve as critical foundation to design future therapeutic interventions that benefit human health.

Keywords: lymph node,spatial organization,stromal cell heterogeneity,stromal cell specification,stromal cell disfunction,dendritic cells,asthma
Development and commercialisation of the hand-held smart testing equipment for the instantaneous quality control of the concrete and cement (ConcTest)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-08-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cementitious materials are used in virtually all construction and engineering projects and the far reaching consequences of poor quality control cannot be underestimated. This is illustrated by the numerous examples of structural failure in buildings and civil engineering projects and the disastrous failure of the cement of the Maconda oil well in 2010 causing the BP Deepwater Horizon oil spill and explosion killing 11 people and injuring 17 others, plus enormous environmental damage. There are a large variety of tests that are applied to cements and concretes including slump tests, compactability, flow table tests, density and air content. These tests yield results in a short period of time so a batch that does not meet the specification can be identified quickly. However, the direct measurement of strength according to standards BS EN197-1:2011/EN196-1 (cement) and BS EN 206:2013/ BS EN 12390-1:2012 (concrete) requires that samples are cured for 28 days. Concrete and cement manufacturers, concrete suppliers and their customers all experience long delays waiting for confirmation of the strength of cementitious building products. Our ConcTest technology alleviates such uncertainty. The handheld instrument rapidly and reliably predicts the ultimate strength whilst the concrete (or cement) is in the wet state. This provides the whole value-chain with high levels of confidence regarding the strength that will be achieved allowing better stock management. Out of specification batches can be identified and corrected immediately, and building and construction projects can assess the quality of concrete on the day of pouring, avoiding the need for remedial works if the product fails the 28 day tests. This project application relates to commercialisation of a truly novel and ground-breaking device which will be used for the rapid quality assurance of cementitious products through the whole value-chain.

Keywords: concrete testing,compressive strength testing,ready mixed concrete,cement
Trade at the Sea of the Rising Sun: Neo-Elamite commercial involvement in the Persian Gulf network (1000-525 BC) (TRADElam)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Australia,Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2024-09-30
Duration (months): 36.0
Total project cost (EUR): 254633.28
EU funding (EUR): 254633.28
Participants: 2
Project status: TERMINATED

Since the 3rd millennium BC, the Persian Gulf has been a key international trade route both connecting the civilisations around it, such as Elam, Mesopotamia, Dilmun and Magan, and orienting these societies towards the Indian Ocean. The lack of diversity in natural resources on both sides of the Gulf motivated early Middle Eastern states to explore maritime trade in order to obtain and exchange raw materials and finished products (e.g. copper, timber, textiles). Especially, littoral societies on the shores of the Gulf shared a maritime culture based on long-distance trade, and were part of an interlinked system that included agricultural villages and oases that sustained the caravan trade. In order to achieve a deeper understanding of interregional contacts between Elam, Mesopotamia and Eastern Arabia, one requires a profound knowledge of the political climate promoting commercial exchange, the maritime and overland trading itineraries, the import and export products, and the people involved in these commercial networks. TRADElam aims to study the commercial relations and trading networks in the Gulf region during the 1st half of the 1st millennium BC. While there is abundant maritime traffic recorded for the 3rd-2nd millennium BC, traces of Gulf commerce become scarce in the early 1st millennium BC. The first part of the project will therefore create a general overview of the commercial networks between Elam, Eastern Arabia and Mesopotamia during the 1st half of the 1st millennium BC. To achieve this, one will study the maritime and overland trade routes and identify the natural resources as well as the import and export products of each region. The second part will focus on the role of the indigenous coastal communities involved in these commercial relations.

Keywords: persian gulf history,ancient maritime trade,elam,mesopotamia,eastern arabia
Feeding Anglo-Saxon England: The Bioarchaeology of an Agricultural Revolution (FeedSax)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-09-01
End date: 2022-11-30
Duration (months): 63.0
Total project cost (EUR): 1933165.0
EU funding (EUR): 1733683.75
Participants: 2
Project status: SIGNED

By the time of the Norman Conquest in 1066, England’s population was again comparable to that of Roman Britain and included substantial urban centres. By 1200, England was more densely populated than ever before. Such population growth was mirrored across much of Europe. It drove the expansion of towns and markets and was fed, literally, by an increase in agricultural productivity that involved a fundamental reorganization of the countryside. The social, economic and demographic consequences of this reorganization were so far-reaching that it has often been described as an ‘agricultural revolution’. At the heart of this proposal is the question, how and when was this revolution achieved? FeedSax will effect a breakthrough in understanding this critically important period in Europe’s agricultural history by generating new, direct evidence for changing land-use from the excavated remains of crops, animals and farms. The timing and nature of the ‘cerealisation’ of England have been debated for over a century, with arguments focusing on the origins of open fields. These arrays of strip fields were communally cultivated, requiring collective decision-making and sharing of resources. Peasant households therefore had to live close together, giving rise to the nucleated villages that remain such a striking feature of the landscape. Fields thus created communities, reconfiguring both landscapes and social geography. The spread of open fields laid the foundations for the modern countryside and is widely regarded as one of the transformative changes of the Middle Ages, yet theories about when and how this unprecedented type of agriculture emerged and spread are based on limited, indirect written and archaeological evidence. FeedSax breaks new ground by integrating scientific methods such as stable isotope and pollen analysis, radiocarbon dating, archaeobotany and archaeozoology with structural remains to resolve this hitherto intractable problem.
Computational dynamics studies of drug metabolism by P450 enzymes (metabolicomp)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-21
End date: 2019-06-20
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Cytochrome P450 enzymes monitor the metabolism of many drugs and small-molecules, as well as selectively catalyze hydrocarbon substrates for application in biotechnology. Drug-drug interactions are critical to the management of safe and effective pharmaceutical treatments. Thus, it is important to better understand the biological functions and activities of P450 enzymes not only to maximize their clinical significance but also to develop broader application in other fields, such as biofuel. There has been significant investment in computational and theoretical studies of P450 enzymes; however, there remains a need for further dynamical calculations to better explore the involvement of the enzyme active site in competing pathways leading to various products. This project aims to determine the role of P450 enzyme in alcohol and alkene formations, compare and contrast heme and non-heme Fe-containing active sites, and model the effect of enzyme environment, using quantum mechanical calculations and inherent dynamics via quasi-classical simulation. The results from this study will help advance the field of computational modeling and its application in biologically important systems.
Improved Communication of High Impact Weather Events (Vis4Weather)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-03-01
End date: 2018-08-31
Duration (months): 18.0
Total project cost (EUR): 148750.0
EU funding (EUR): 148750.0
Participants: 1
Project status: CLOSED

In the scope of my ERC Advanced Grant “SaferVis", I have focused especially on the development of novel concepts and algorithms for analysing the uncertainty that is represented by an ensemble of simulations of a physical phenomenon, such as ensemble weather forecasts. Instead of making a single deterministic computation of the future weather state, today the weather centres worldwide compute ensembles of numerical forecasts routinely using operational ensemble prediction systems. Weather forecasts then take the form of probabilities of occurrence of weather events, which are derived from the ensemble fields. In the scope of SaferVis we have developed the opensource software tool Met.3D for 3D meteorological ensemble visualization. In the PoC, I aim to study a) the potential of an operational use of Met.3D at weather centres, b) the potential of Met.3D for training forecasters, decision makers and researchers in 3D ensemble visualization, c) the possible societal impact of (3D) ensemble visualization for communicating uncertainty in forecasts of high impact weather events to the public, and d) Met.3D’s potential for commercialization.

Keywords: ensemble based weather forecasting,high impact weather communication,societal impact
Peer-2-peer Car Sharing (P2PCS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Netherlands
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

CarShare Ventures B.V. (CSV) has developed SnappCar, a peer-to-peer car sharing platform on which consumers can offer their car for rent for one or more days to other potential users. In others words: SnappCar is the equivalent of “AirBnB for cars”. CSV lowers risks and increases trust by arranging insurance, payments and screening potential users. Currently the average European car owner only makes use of his/her car one hour per day. CSV perceives the tremendous amount of unused cars as a business opportunity with a societal impact. This is supported by economic, societal and environmental arguments. Preliminary market research has indicated untapped user potential and latent interest in car sharing in the following three European regions: North West Europe, Central & Eastern Europe and Southern Europe. Convincing car owners to share their cars, has proven a difficult and time-consuming exercise that requires a different and personalized approach per location. This Phase 1 feasibility study is necessary to investigate selected metropolitan areas in these zones in more detail, create a solid business strategy and tailor the current platform accordingly (removing cultural, technical, legal and economical market barriers) to access and engage the end-users of each region, in order to execute the envisioned Phase 2 follow-up demonstration project. This proposal fits with topic SME Inst 10: Small business innovation research for Transport and Smart Cities Mobility of the Horizon2020 work programme and addresses topics of the Transport White Paper of 2011, where car sharing is mentioned as part of initiative 27: “Promote the awareness of the availability of alternatives to individual conventional transport”.

Keywords: car sharing,mobility,transport,metropolitan areas,pay for use,polluter pays,greenhouse gasses reduction,more conscious car use,sharing economy,connecting citizens
Automated super-resolution polarimetric nonlinear microscope 'PolarNon' (PolarNon)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Switzerland
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-10-01
End date: 2021-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The analysis of materials is a key requirement for device quality control in medical, electronic and photonic industry. Currently, fluorescence imaging, electron microscopy and photoluminescence are typical tools for quality control in research and industry. However, they suffer from several limitations: complex samples preparation, special environments, destructive and time-consuming measurements. The development of new materials and components needs innovative approaches for fast and non-destructive testing (NDT). We propose to use nonlinear optical responses that are strongly dependent on material properties like crystal structure, defects and roughness for NDT. Despite the high potential of nonlinear optics in material sciences, the existing solutions are not convenient in terms of equipment, measurements methods, sample preparation and human resources costs. We propose the implementation and testing of a fully automated polarimetric nonlinear microscope ‘PolarNon’ as a hardware and software solution for NDT and quality control of materials or optoelectronic components in the semiconductor industry (Market segment I), and metallic or ceramic alloys in the aerospace industry (Market segment II). The PolarNon system overcomes the limitations of current methods: it does not require special sample preparation or measurement conditions, like low temperatures, vacuum or ultrathin substrates, and it can characterize materials already incorporated in a device. The PolarNon includes a method of per-pixel analysis of optical images to reconstruct the material crystalline properties down to the pixel resolution. We already successfully applied this approach to several materials for predicting samples inner structure. This project allows us to build an industrial prototype for future commercialization and secure the invention to create an engineering start-up focused on the development of nonlinear optical microscopy tools for material analysis.

Keywords: perovskite nanomaterials,lithium niobate,barium titanate,mie scattering,dielectric particle,solution processed photonic crystal,nanoimprint lithography,nanowire,ultrafast photonics
Towards improvement of ruminant breeding through genomic and epigenomic approaches (RUMIGEN)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Spain,Norway,Belgium,Sweden,France,France,Netherlands,Netherlands,Denmark,Denmark,United Kingdom,Denmark
Call: Genome and epigenome enabled breeding in terrestrial livestock (H2020-SFS-2020-2, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 7493617.75
EU funding (EUR): 6998851.5
Participants: 19
Project status: SIGNED

More sustainable breeding programs and linked technologies need to be in line with social demand and to take into account genetic diversity as well as required adaption to climate change. Towards these aims, RUMIGEN will ensure engagement of a variety of stakeholders to assess social perception of breeding objectives and related technologies in ruminants. It will define “rooms of acceptance” which will be implemented in sustainable breeding scenarios that will then be assessed through multi-actor panels. To define new breeding programs, RUMIGEN, which brings together partners representing pan-European leaders on ruminant breeding, will question trade-offs and pleiotropic effects through adaptation to environmental stressors such as heat stress. Cosmopolitan and local dairy cattle breeds will be analysed evaluating mid to long term effects as well as impact on next generation (fetal programming). This work will rely on large-scale data from commercial farms combined with climatic data, taking advantage of the large panel of situations across Europe and of a unique design involving half-sister cows raised in contrasted conditions, Denmark and India. Diversity will be also studied with new breed genome assemblies. Methods will be developed to account for rare alleles and to maintain diversity. An epigenotyping platform will be designed to (i) explore sperm epigenome influences on bull fertility and progeny, (ii) decipher underlying mechanisms of epigenetic inheritance and (iii) evaluate how much epigenetic biomarkers improve phenotype prediction. RUMIGEN will answer questions on genome editing specificity and safety issues, assessing its potential to preserve genetic diversity and increase genetic gains. Overall, RUMIGEN will develop models combining genomics, epigenomics and biotechnologies to improve genomic selection, preserve genetic biodiversity and avoid genetic load. Improved phenotype prediction will pave the way to new management indexes for precision farming.

Keywords: social acceptability,genome editing,climate changes,biodiversity,sustainability