Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Simulations of Topological Phases in Superconducting Circuits (TOPOCIRCUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-16
End date: 2022-09-15
Duration (months): 36.0
Total project cost (EUR): 251002.56
EU funding (EUR): 251002.56
Participants: 2
Project status: CLOSED

The discovery of topological order characterising novel exotic phases of matter has generated a breakthrough in the comprehension of complex condensed matter phases. Topological invariants entirely determine the behaviour of certain observables and confer to the systems a strong robustness to perturbations. Going beyond condensed matter states, topological order can be engineered in different setups that can benefit form it and represent alternative platform for the simulation of exotic topological phases. One of the most promising candidate for such a plan is represented by superconducting circuits based on the Josephson effect. The present proposal aims at studying the interconnections between the topological notion and the Josephson effect and to propose superconducting circuits as a platform for the simulation and manipulation of novel topological phases of matter.

Keywords: topological phases,josephson junctions,caloritronics
Synthetic Oligonucleotide Quality Control Software (SOLQC)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Israel
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-03, 2018)
Start date: 2019-07-01
End date: 2020-06-30
Duration (months): 12.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

DNA synthesis technology has greatly developed over recent years, serving a growing multi-billion synthetic DNA market. Synthetic DNA is used in projects that optimize reagents, chemicals, crops and other organisms, in projects seeking to increase the manufacturing efficiency for the above, as well as in studies of molecular regulation and other cellular processes. The latter is the focus of the MRG-GRammar H2020 FET project. As the market and application range for synthetic DNA expand a need arises to test and quality control raw synthetic nucleic acids as well as products built upon such reagents. We have developed a prototype software tool for assessing quality parameters in synthetic DNA libraries and used it in several projects in the framework of MRG-GRammar We propose to productize this prototype into a stable version that will be availed to a broader synthetic biology community. Our proposed product, SOLQC, is a software system that enables management, control and feedback in projects based on synthetic DNA and its applications. Requested funding will be used to improve usability and user interface, to expand the implementation of analysis and statistical tools, to produce a stable version available to the scientific community and to commercial entities and, finally, to investigate potential sustainable mechanisms for supporting continued service, including commercial or service models

Keywords: software system,synthetic dna,quality parameters
Linking mechanics and endoreduplication with tissue folding (MendoFold)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2023-01-25
Duration (months): 24.0
Total project cost (EUR): 203852.16
EU funding (EUR): 203852.16
Participants: 1
Project status: CLOSED

Tissue folding plays a key role in the development of all multi-cellular organisms. The aim of this MSCA-IF fellowship is to decipher the poorly understood mechanisms involved in regulating tissue folding in plants, using the apical hook as a model. The hook forms via tissue folding driven by differential cell elongation in the embryonic stem (hypocotyl) and is critical for the survival of young seedlings, since it protects the shoot apical meristem from damage as it passes through soil during seedling germination. Work in the host lab has recently shown that endoreduplication (DNA replication without subsequent cell division) is involved in hook development. Since plant cells are enclosed by rigid cell walls, it is hypothesized that tissue folding during apical hook formation involves an interplay between endoreduplication, cell wall mechanics and hormonal signals which will be deciphered by Dr. Yuan Ma during this fellowship. Simultaneously, Dr. Ma will receive training in cutting- edge techniques like atomic force microscopy, flow cytometry, and immunocytochemistry in leading environments such the host lab at SLU/UPSC (Umeå, Sweden) and via secondments to VIB (Ghent, Belgium) and ENS (Lyon, France). Synergistically complementing skills in biochemistry and genomics gained during his PhD, this training will provide Dr. Ma with a unique technical and theoretical expertise in experimental biomechanics, strongly promoting a successful achievement of the project’s goals, opening of new vistas in developmental biomechanics, and support the researcher’s ambition of becoming a research leader. The researcher will follow a personalized career development plan, to also enhance skills such as communication, grant writing, public engagement and student mentoring. Thus, this MSCA-IF will enable elucidation of a key process in developmental systems biology (with important applications in tissue engineering), and career advancement of a scientist with outstanding potential.

Keywords: tissue folding,endoreduplication,cell wall mechanics,hormones,apical hook
Ensuring long-term sustainability of excellence in chemical biology within Europe and beyond (EU-OPENSCREEN-DRIVE)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Israel,Germany,Germany,Germany,Spain,Spain,Spain,Spain,Finland,Switzerland,Norway,Norway,Norway,Hungary,Sweden,Norway,Greece,Poland,Poland,Poland,Romania,Latvia,Czechia,Czechia,Czechia,Netherlands,Denmark,Portugal
Call: Individual support to ESFRI and other world-class research infrastructures (H2020-INFRADEV-2018-1, 2018)
Start date: 2019-02-01
End date: 2023-10-31
Duration (months): 57.0
Total project cost (EUR): 4999563.5
EU funding (EUR): 4999563.5
Participants: 34
Project status: SIGNED

EU-OPENSCREEN (EU-OS), the European Research Infrastructure of Open Screening Platforms for Chemical Biology, builds a distributed organization of national screening and chemistry facilities, a common database, and a central headquarter that manages the joint compound collection and coordinates project flow and training. It provides world-class services to academia and industry in the fields of small molecule screening and medicinal chemistry. EU-OS developed its concept and business plan during the preparatory phase and has received information on the Commission Implementing Decision on setting up the EU-OS European Research Infrastructure Consortium (EU-OS-ERIC) in March 2018. In 2018, EU-OS will start its ERIC operations with seven founding members and one observer. EU-OS will promote the rich chemical knowledge of Europe and enabling systematic studies of the bioactivities of a larger collection of compounds leading to ground-breaking insights into cellular and organismal metabolic or signalling pathways. After careful consideration of IPR from all stakeholders involved, all results will eventually become available to the public. EU-OS will thereby also play an increasingly important role in facilitating the drug discovery process in Europe. In addition, it also has a great potential for innovative development of biomarkers and other diagnostics. By carefully considering the recommendations of the Long-term Sustainability Action Plan of the EC and ESFRI, EU-OS will utilize EU-OS-DRIVE to specifically promote measures for i) widening awareness of academia and industry for its services and data, ii) growing capacity and competence in its field across Europe, and iii) completing the management processes needed for a large distributed infrastructure. EU-OS-DRIVE will further help the EU-OS-ERIC to deliver its added-value via constant re-use of generated data and tools by users across the globe and to support the competitiveness of European life science industries.

Keywords: research infrastructure,small molecule screening,medicinal chemistry,compounds,chemical biology,biochemical,biological,biomedical,tools,training,industry engagement,growing capacity
Evolution of viral codon usage preferences:manipulation of translation accuracy and evasion of immune response (CODOVIREVOL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-01-01
End date: 2022-06-30
Duration (months): 78.0
Total project cost (EUR): 1997100.0
EU funding (EUR): 1997100.0
Participants: 1
Project status: CLOSED

Fidelity during information transfer is essential for life, but it pays to be unfaithful if it provides an evolutionary advantage. The immune system continuously generates diversity to put up with recurrent pathogen challenges, and many viruses, in its turn, have evolved mechanisms to generate diversity to evade immune restrictions, even at the cost of enduring high mutation rates. Synonymous codons are not used at random and are not translated with similar efficiency. A large proportion of viruses infecting humans, especially those causing chronic infections, display a poor adaptation to the codon usage preferences of their host. This observation is a paradox, as viral genes completely depend upon the cellular translation machinery for protein synthesis. The poor match between codon usage preferences of virus and host negatively affects speed and accuracy of viral protein translation. We propose here that maladaptation of codon usage preferences in human viruses may have an adaptive value as it decreases translational fidelity, results in the synthesis of an ill-defined population of viral proteins and provides a way to escape immune surveillance. We will address the fitness effects of codon usage bias at the molecular and cellular levels, and later at the organism level in a rabbit model of papillomavirus infection. We will apply experimental evolution to analyse genotypic changes by means of next generation sequencing and will monitor phenotypic changes through real-time cell monitoring techniques, comparative proteomics, and anatomopathological analysis of virus-induced lesions. Our results will help solve the evolutionary puzzle of codon usage bias, and will have implications for the development of therapeutic vaccines to guide the immune response towards the identification and targeting of the main protein species, avoiding the chemical noise generated by protein mistranslation.

Keywords: codon usage,experimental evolution,infection and cancer,chronic infection,immune escape,protein synthesis,translational selection
Climate and marine-ecosystem predictions in the Angola-Benguela Upwelling System (BENGUP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 202158.72
EU funding (EUR): 202158.72
Participants: 1
Project status: SIGNED

The Angola-Benguela Upwelling System located off the south-west African coasts sustains a very diversified marine ecosystem. This region undergoes the occasional manifestation of extreme interannual warm events known as Benguela Niño events that can devastate the ecosystem, deplete the fish stocks and therefore affect the economy of south-west African developing countries. To ensure the long-term sustainability of the living marine resources, there is an urgent need to provide reliable and useful seasonal predictions of the marine environment and ecosystems to local stakeholders and economic actors. Recently, studies of the applicant and the host institution have revealed the potential of prediction of those extreme Benguela events. The BENGUP project seeks to develop the first climate-based marine ecosystem predictions of these abrupt environmental events and outlooks of fish stock in this region. Model prediction skills and related uncertainties will be assessed for the key ocean drivers of interannual variability in the region using existing dynamical systems. Based on this knowledge, a new prediction system capturing the predictability of extreme events and their impact on the marine ecosystem will be developed. Given the strong socio-economic and ecological implications, the outputs of this action will not only be of high impact to the local communities and fisheries, but will be also of broad interest to a wide array of disciplines, including marine biologists, climate modellers, policymakers, and members of the informed public. Through the fellowship, I will transfer my knowledge in regional modelling of South-Eastern Atlantic Ocean variability to the host institutions while adding a new discipline (climate prediction) and cutting-edge statistical techniques to my expertise. This project will represent a huge step in my career as it will position me as a leader in the growing field of climate-based marine ecosystem predictions.

Keywords: south eastern atlantic ocean,benguela ninos,seasonal predictions,earth system modelling,ocean variability
Meet and learn What Excellent science does FOR YOU and the society (WeForYou)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Slovenia
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-04-01
End date: 2015-09-30
Duration (months): 18.0
Total project cost (EUR): 79737.5
EU funding (EUR): 71765.0
Participants: 1
Project status: CLOSED

Meet and learn What Excellent science does FOR YOU and the society is the major focus of the coordinated WeForYou action in performing the European Researchers’ Night 2014 and 2015 in Slovenia. Energy research & innovation, Environment & Climate Action, Health and ICT Research & Innovation are the priorities which will be tackled by a series of actions and opportunities for interchange of knowledge in the European Researchers’ Night 2014 and 2015 in Slovenia. The events in 2014 and 2015 in Slovenia will take place in: - Ljubljana, the main city square organized by Jožef Stefan Institute (JSI); - Novo mesto, organized by Faculty of Information Studies; - Piran and Piran bay, organized by National Institute of Biology; - Planica, Planetary Habitat Simulation Centre organised by JSI; - Krško, organized by Jožef Stefan Institute (JSI) The European Researchers' Night aims to bring researchers to the general public and to increase awareness of research and innovation activities, with a view to support the public recognition of researchers, creating an understanding of the impact of researchers' work on citizen's daily life, and encouraging young people to embark on scientific careers. Among the goals of WeForYou is one of special importance - presenting the researchers that have shown excellency in their results and achievement as ordinary people. Activities that are planned will enable the wide public audience to identify itself with the researchers’ life and to promote science in a firm expectation that the passed message to the young people will embark them on scientific careers. Children and adults addressed within the WeForYou activities will have the opportunity to understand science by experiencing its day-to-day practices, by frequenting the spaces and places where research is carried out and by coming into contact with its machinery and equipment, but above all by talking to those directly involved in scientific research that brings benefit to the society.

Keywords: communication,science communication,public recognition of researches,promotion of science careers,energy,environment,health,technology,ljubljana,novo mesto,piran,planica,kr ko
OpenRiskNet: Open e-Infrastructure to Support Data Sharing, Knowledge Integration and in silico Analysis and Modelling in Risk Assessment (OpenRiskNet)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: e-Infrastructures
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Spain,Greece,Sweden,Switzerland,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: User-driven e-infrastructure innovation (H2020-EINFRA-2016-1, 2016)
Start date: 2016-12-01
End date: 2019-11-30
Duration (months): 36.0
Total project cost (EUR): 2999112.5
EU funding (EUR): 2999112.5
Participants: 12
Project status: CLOSED

Toxicology and risk assessment are undergoing a paradigm shift, from a phenomenological to a mechanistic discipline based on in vitro and in silico approaches that represent an important alternative to classical animal testing applied to the evaluation of chronic and systemic toxicity risks. Large databases and highly sophisticated methods, algorithms and tools are available for different tasks such as hazard prediction, toxicokinetics, and in vitro – in vivo extrapolations to support this transition. However, since these services are developed independently and provided by different groups world-wide, there is no standardized way how to access the data or run modelling workflows. To overcome the fragmentation of data and tools, OpenRiskNet will provide open e-Infrastructure resources and services to a variety of communities requiring chemical risk assessment, including chemicals, cosmetic ingredients, therapeutic agents, and nanomaterials. OpenRiskNet will combine the achievements from earlier projects for generating modeling and validation workflows, knowledge integration and data management as well as include all ongoing projects and important stakeholders through an associated partner programme. The main components of the infrastructure will be an interoperability layer added to every service to describe the functionality and guaranteeing technical and semantic interoperability, a discovery service, deployment options based on container technology, and packaging of the infrastructure into virtual instances. This will be complemented by training and support on integration of specific services based on prototype implementation, usage of standard file formats for data sharing including the generation of templates for data and metadata, as well as the harmonized usage of ontologies. Case studies will demonstrate the applicability of the infrastructure in productive settings supporting research and innovation in safer product design and risk assessment.

Keywords: risk,safety,data,assessment,knowledge,integration,analysis,modelling,services,infrastructure
Breaking barriers between Science and Heritage approaches to Levantine Rock Art through Archaeology, Heritage Science and IT (LArcHer)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Spain,Spain
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-10-01
End date: 2025-09-30
Duration (months): 72.0
Total project cost (EUR): 1991178.0
EU funding (EUR): 1738053.0
Participants: 2
Project status: SIGNED

LArcHer project aims at pioneering a new and more comprehensive way of understanding one of Europe’s most extraordinary bodies of prehistoric art, awarded Unesco World Heritage status in 1998: Levantine rock art (LRA). The ground-breaking nature of the project relies on combining a multidisciplinary (Archaeology, Heritage Science and IT) and multiscale approach (from microanalysis to landscape perspectives) to gain a holistic view of this art. It also aims at closing existing gaps between science and heritage mainstreams, to better understand the values and threats affecting this tradition and bring about a change in the way we understand, care, use and manage this millenary legacy. LArcHer aims are: a) Use cross-disciplinary knowledge and methods to redefine LRA (i.e. new dating techniques to refine chronology, new analytical methods to understand the creative process); b) Use LRA as a proxy to raise new questions of global interest on the evolution of creative thinking and human cognition (i.e. the timing and driving forces behind the birth of anthropocentrism and visual narratives in the history of prehistoric art); c) Develop new research agendas to set off complementary goals between science and heritage and define best practices for open air rock art conservation and management. Spread across Mediterranean Iberia, LRA is the only European body of figurative art dominated by humans engaged in dynamic narratives of hunting, violence, warfare, dances and so forth. These scenes are unique to explore past social dynamics, human behaviour and cultural practices. As such, it is the only body of European rock art with potential to answer some of the new questions raised by LArcHer. Key to LArcHer are the systematic recording and analysis of the art through 3D Digital technologies, management and data storage systems, GIS, physicochemical analysis of pigments and bedrock and comparative analysis with other major bodies of art with equivalent developments.

Keywords: rock art digital image technologies pigment analysis gis it heritage sciences conservation