Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The role of social presence on moral decision-making : realistic settings for the understanding of utilitarian and deontological preferences (YOURMORALS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

In our modern societies, moral situations often refer to saving, hurting, condemning, or sparing peers. The direction of our moral preferences (e.g., utilitarian, deontological) is inherently shaped by social norms and social context. However, current experimental research on moral cognition suffers from two main limitations. First, while a wealth of research has examined individual’s moral preferences in single settings, no research to our knowledge has examined individual’s moral preferences in real-life social settings. Second, because of the long-standing paradigm involving the use of hypothetical and sacrificial dilemmas to measure decision-making (i.e., save or sacrifice lives), we assume there is a discrepancy between hypothetical and realistic moral decision-making. Compared to the current state-of-the-art, YourMORALS will allow for the first time to assess the role of social presence on individual’s moral preferences, shedding light on both cognitive and neural processes underlying responses to realistic scenarios. This research will combine behavioural and neurophysiological paradigms by using a unique experimental system allowing to mimic social context through dyadic interactions. The proposed experiments will permit to clarify the role of social presence through, 1) indirect exposition to other’s moral choices (single setting), 2) direct presence of other (social setting). The latest innovative EEG-based hyperscanning techniques will be used to measure multiple brains’ activity. We will also construct an open, standardized and realistic moral dilemmas dataset. As well as opening new perspectives in social neuroscience and psychology, this project will add theoretical and methodological expertise to my skill-set by providing the most suitable research environment for my career development, at the Moral and Social Brain Lab, in one of the top-ranking universities of Europe (Ghent University), under Prof. Emilie Caspar supervision.

Keywords: moral decision making social presence moral dilemmas eeg hyperscanning
From Double Motherhood to Surrogacy. Anthropology of Kinship, Gender and Globalization in Contemporary Urban China (DOUMOTHERCHINA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Studies of Cultures and Arts
Panel description: Social anthropology, studies of cultur es, stud ies of arts
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499117.0
EU funding (EUR): 1499117.0
Participants: 1
Project status: SIGNED

Using reproductive medicine is not a recent practice in China. While authorized artificial insemination and In Vitro fertilization have become common practice, the commercialization of gametes and surrogacy remains officially prohibited. However, an underground market of agencies and medical establishments has emerged in major cities, responding to the growing demands from the LGBTQ+ community and heterosexual couples who have lost their only child. How do the Assisted Reproductive Technologies (ARTs) and the surrogacy market operate in China? Why do some Chinese intended parents, when pursuing surrogacy abroad, anticipate having mixed-race children? How do these new reproductive practices challenge the traditional system of patrilineality and the conception of parenthood? As China experienced its first demographic decline in 2022 for the past sixty years, policies related to ARTs have gradually relaxing in recent years. How does this demographic challenge influence the political and legal development related to reproductive technologies? What kinds of ethical, legal, kinship, and gender issues are associated with surrogacy and ARTs in China, and how do they differ from those in European and American societies? This project delves into the realm of ARTs and surrogacy in China, an unexplored area within the anthropology of contemporary kinship, primarily founded on European and American societies. Employing an interdisciplinary approach that combines anthropology, law, history and literature, this endeavor aims to enhance our understanding of Chinese modernity, contribute to a shift in anthropological knowledge about contemporary kinship, and shed light on the construction of bioethics and reproductive medicine laws in China. These insights may offer valuable reference points for other regions and countries, particularly in Europe, where ARTs remain contentious topics in public and political discussions.

Keywords: kinship,surrogacy,gender,assisted reproductive technologies,parenthood,lgbtq,demographic policies,polygyny,race,sexuality,conjugality,intergenerational relationships,china
In situ growth of thermoplasmonic nanoparticles in microfluidic platforms for modifying stem cell fate (PLASMOSTEMFATE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: SIGNED

The overarching goal of PLASMOSTEMFATE is to enable facile, inexpensive, and scalable fabrication of thermoplasmonic-microfluidic NSC culture platforms, posing transformational impacts in tissue engineering and regenerative medicine, addressing UNESCO sustainable development goal 3 (good health and wellbeing) and Mission Cancer of Europe’s Beating Cancer Plan. Thermoplasmonic gold nanoparticles can generate localized heat in response to biologically transparent near-IR light and their size- and shape-related properties can be leveraged to non-invasively monitor and direct the lineage commitment of neural stem cells (NSCs). This action will deploy and develop unconventional in situ nanoparticle synthesis to form shape-controlled thermoplasmonic nanoparticles directly inside microfluidic devices. The proposed platforms will significantly advance the controlled implementation of micro- and nano- structures as tools for manipulating NSC behaviors, by systematically applying both controlled fluid flows and plasmonic enhanced heating to modulate the cell microenvironment. The action will be hosted by Prof. Luis Liz-Marzán at CIC biomaGUNE, with Prof. Stephanie Seidlits’ group at the University of Texas at Austin as a secondment. This multidisciplinary action relies on collected expertise in plasmonics, bottom-up nanoparticle synthesis, microfluidics, and NSC biology. My strong background in in situ synthesis, thermoplasmonic nanoparticle characterization, and microfluidics offer synergies with the host and secondment for generating new research lines and strengthening collaborations between the two institutions. Ultimately, this action will expand my scientific network internationally, enable me to hone my skills in the rational synthesis of plasmonic nanostructures and acquire knowledge in fundamental stem cell biology, improve my mentorship expertise, and lay the foundation for a successful career as an independent researcher at a top university or research center.

Keywords: plasmonics,gold nanoparticles,in situ growth,neural stem cells,differentiation,microfluidics,plasmonic heating,confocal raman microscopy
Addressing complex risks from climate change and biodiversity loss across systems and scales: Leveraging the potential of tree-based solutions for adaptation in Europe (Trees4Adapt)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Research and Innovation actions
Countries involved: Finland,Belgium,Germany,Austria,United Kingdom,Portugal,Ireland
Call: Research the complex interplay between the climate and biodiversity crises towards more systemic approaches and solutions (HORIZON-MISS-2024-CLIMA-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 3999290.0
EU funding (EUR): 3999290.0
Participants: 12
Project status: SIGNED

Climate change and biodiversity loss are interdependent crises, but knowledge gaps on their interplays prevent effective risk assessment and solutions. Trees4Adapt will 1) enhance empirical understanding of climate change, biodiversity loss, their interdependencies, and how these influence risks; 2) develop evidence-informed tools and solutions that build climate resilience and support biodiversity at the same time. We focus particularly on tree-based solutions, which are nature-based solutions involving trees that promise to safeguard the EU by delivering cross-sectoral benefits, if we better tailor their design and implementation. Trees4Adapt combines field-quantified understanding from multi-national research platforms and case studies representative of boreal, temperate, and Mediterranean biomes with novel bioeconomic modelling and high-resolution modelling and mapping of complex risks. Our activities operate from the plot- to EU-level, with interdisciplinary models developed during the project integrating the scale-dependent findings. Trees4Adapt applies co-creational approaches, and key stakeholders - including public administration and authorities - from the local- to EU levels will actively guide, inform, and participate in the project. This will ensure the outputs of our research are useable, custom-made to stakeholders’ specific needs, and result in changes in decision-making and other impact in relation to recognised societal needs and key EU and global policy priorities including the Climate Adaptation, Forest, and Biodiversity Strategies. Trees4Adapt’s consortium consists of leading experts on climate change science, ecosystems and land use changes, nature-based solutions, transdisciplinary and participatory research, bioeconomics, environmental policy, risk assessment and modelling. Ultimately, Trees4Adapt aims to work with and support EU decision-makers to successfully assess and address complex risks from climate change and biodiversity loss.

Keywords: microclimate,forest dynamics,forest modelling,economics,bioeconomy,stakeholder engagement,co creational research,experimental networks,hydrology,ecosystem service,agroforestry,trees
Central and Eastern European Security Cooperation Cluster (CENTREPEACE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Social Sciences and Humanities
Countries involved: Czechia,Norway,Finland
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 1498629.25
EU funding (EUR): 1498629.25
Participants: 3
Project status: SIGNED

In the wake of Russian aggression against Ukraine, the position of Central and Eastern Europe (CEE) in the security architecture of the EU has become crucial. However, the voice of security research from the region is not well represented in security debates on the European and global level. The International Institute of Political Science (IIPS) of Masaryk University (MUNI) is perfectly positioned to address this disbalance, with its unique expertise of CEE in terms of area studies and outreach to policy sector. By twinning with leading European research centres in security and area studies: Peace Research Institute Oslo (PRIO) and Aleksanteri Institute at University of Helsinki (UoH), we seek to develop a promising research avenue focused on security cooperation and integrate the IIPS in international networks supported by Horizon Europe. We will follow three specific objectives: (1) Strategic networking: coordination of MUNI, PRIO, and UoH research on security cooperation and building a pathway for sustainability through systematic development of follow-up projects. (2) Developing culture of excellence at IIPS for both researchers and research managers and administrators (RMAs): delivering a research programme, training and knowledge exchange, empowerment of young researchers and female researchers. (3) Developing pathways to societal and academic impact in the field of security cooperation. Our actions will transform IIPS at MUNI into a hub for international, intersectoral, and interdisciplinary collaboration on security cooperation. Beyond that, the training, networking, and integrative actions will help transform the broader environment for research in political science and international relations at MUNI, making it a recognized and attractive place to seek careers in research. Finally and ultimately, we will contribute to bringing CEE from the periphery of security discourse towards the centre, making the EU security policy more balanced and inclusive.

Keywords: security cooperation cognitive warfare defence industrial cooperation central and eastern europe eastern partnership
Development of novel viral vectored vaccines against Marburgviruses inducing robust and cross-reactive protection (MARVAX)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Germany,France,Spain
Call: Pandemic preparedness and response: Immunogenicity of viral proteins of viruses with epidemic and pandemic potential (HORIZON-HLTH-2023-DISEASE-03, 2023)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 7439560.0
EU funding (EUR): 7439560.0
Participants: 4
Project status: SIGNED

The frequency, magnitude, and geographical range of Marburg virus disease outbreaks are expanding, with recent cases emerging in Equatorial Guinea and Tanzania. Marburgviruses, listed among the WHO priority pathogens, have demonstrated their epidemic potential. However, no licensed vaccines are available, and outbreaks continue to impose high morbidity and mortality burdens. Vaccine candidates in the pipeline are based on the Marburg virus (MARV) glycoprotein (GP) as a single immunogen. MARVAX ambition is to improve the strength and breadth of MARV vaccines by deploying the measles virus (MV) and modified vaccinia virus Ankara (MVA) viral vector vaccine platforms for expression of several MARV antigens: GP, viral protein 40 (VP40), which together with GP allows the formation of virus-like particles, and the nucleoprotein (NP), which contains conserved epitopes that are the main drivers of T cell responses. We will evaluate in depth the innate, adaptive and memory antigen-specific humoral and cellular cross-protective immune responses induced by MV-MARV and MVA-MARV vaccine candidates against MARV, Ravn virus and ebolaviruses, in single dose and in homologous and heterologous prime/boost immunization regimens, through an innovative preclinical testing pipeline. We will use cutting-edge and novel in vitro primary human cell co-cultures and immunocompetent mouse models to evaluate immunogenicity, chimeric and avatar mouse models to evaluate immunogenicity and efficacy and identify correlates of protection, and the highly relevant cynomolgus macaque model to evaluate safety, immunogenicity and efficacy. Furthermore, GMP batches of the best vaccine candidates will be produced by the end of the project, towards their future evaluation in a phase I clinical trial, in collaboration with the WHO-led initiative for prioritization and acceleration of clinical trials of Marburgvirus vaccines in at-risk and healthcare communities and upon outbreaks.

Keywords: marburg virus,vectored vaccines
Elucidating the role of nuclear metabolism in embryo implantation (NucMeta)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 263393.28
EU funding (EUR): 263393.28
Participants: 1
Project status: SIGNED

Embryogenesis involves dynamic epigenetic and transcriptional changes as the zygote divides and cells differentiate into embryonic (epiblast) and extra-embryonic (primitive endoderm and trophectoderm) lineages. Metabolites serve as cofactors or substrates for chromatin-modifying proteins, thus shaping the global epigenetic landscape. Intriguingly, during early development, multiple metabolic enzymes translocate to the nucleus where they might fuel chromatin modifiers. How the interplay between nuclear metabolism and epigenetics regulates cell fate transitions remains unclear. With this proposal, I aim to unveil the role of nuclear metabolism in regulating lineage-specific phenotypes during early development, using implantation as a model. I will focus on this developmental stage as it is characterised by dynamic metabolic and chromatin rewiring. Since implantation relies on proper trophectoderm specification and maturation, I will use embryonic stem cell-derived trophoblast stem cells that transit between pre- and post-implantation-like states in vitro. Specifically, I will establish novel tools to target the degradation of key metabolic enzymes exclusively in the nucleus and assess the impact on gene expression and chromatin modifications. Moreover, I propose to identify the genomic targets and protein partners of nuclear metabolic enzymes. Ultimately, the integration of transcriptomic, genomic, and epigenomic data will unveil the metabolic determinants underlying gene expression and epigenetic changes at implantation.

Keywords: metabolic regulation,chromatin modifications,metabolic enzymes,implantation,trophoblast
Enhancing and Evolving INFRAFRONTIER Disease Modelling Capacity to Enable Breakthrough Research (INFRAPLUS)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,France,Czechia,Finland,Sweden,Spain,Italy,Austria,Greece,United Kingdom,Netherlands,Portugal
Call: Consolidation of the RI landscape – Individual support for evolution and long-term sustainability of pan-European research infrastructures (HORIZON-INFRA-2023-DEV-01, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 4999863.75
EU funding (EUR): 3999891.0
Participants: 21
Project status: SIGNED

In response to the HORIZON-INFRA-2023-DEV-01-03 call, INFRAPLUS aims to expand INFRAFRONTIER's capacity for human disease modelling, refine its service portfolio by reducing animal usage and developing alternative cellular models, and optimise the use of resources. INFRAPLUS seeks to achieve several objectives: Developing national node capacities and expertise for providing innovative in vivo, in vitro and preclinical services, developing novel model systems and services to meet the demands of existing and novel user communities, and reducing environmental impact. To achieve these objectives, INFRAPLUS will focus on launching pilot services, refining new technologies, emphasising alternate cellular models, designing and implementing special training programmes and optimising resources for the entire consortium. The project includes a defined service development strategy supported by a strong IT and data management backbone and is built upon the needs of the scientific community. Ultimately, INFRAPLUS will enhance and evolve INFRAFRONTIER's capacity for modelling human diseases and enable breakthrough research by providing researchers cutting-edge tools and services to respond to global biomedical challenges.

Keywords: mouse,rat,cells,disease,models,crispr,environmental impact,staff capacity,in vitro
Global Value Chain Law: Constituting Connectivity, Contracts and Corporations (GLOBALVALUE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Denmark
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2055441.0
EU funding (EUR): 2055441.0
Participants: 1
Project status: SIGNED

Ongoing struggles over vaccine supplies forcefully illustrates the extent to which Global Value Chains (GVCs) serves as central infrastructures of the global economy and global society. While the COVID-19 pandemic might have been a revelation in this respect, the centrality of GVCs dates back to the dawn of colonialism. Both historically and in contemporary times, GVCs produces profound environmental and socio-economic externalities in jurisdictions often incapable of or unwilling to effectively regulate abhorrent working conditions and environmental degradation. Hence, the question of how to legally regulate cross-border economic processes including the capability of democratically organised political processes to effectively regulate GVCs is a central legal problem within fields such as competition, contract and corporate law as well as environmental, human rights and labour law. Until recently, voluntary soft law measures were the preferred regulatory tools in relation to GVCs. In the last few years, a decisive move towards hard national and EU regulation has however taken place thereby raising the question to what extent this changes the rules of the game. On the backdrop of this development, GLOBALVALUE develops a novel and systematic socio-legal approach to GVC Law. This is done in a threefold manner: Firstly, through a historical sociological reconstruction of GVC Law going back to colonial law countering the currently dominant ahistorical approaches to GVC Law. Secondly, through three comprehensive case studies in relation to the global pharmaceutical, wine and trade fairs industries. Spanning five continents and nine national jurisdictions the case studies will illuminate the effects of contemporary hard and soft law practices of GVC law. Thirdly, through the development of a new concise conceptuality of GVC law with direct implications for our understanding of core legal concepts such as contract, legal order and economic constitutionalism.

Keywords: socio legal studies,sociology of human rights,international economic law,sociology of societal constitutionalism,global justice,legal theory