Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Phenotype switching: plasticity and/or differentiation of stromal cells and their progenitors within the tumour microenvironment regulate tumour fate. (PhenoSwitch)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2023-03-31
Duration (months): 60.0
Total project cost (EUR): 1906250.0
EU funding (EUR): 1906250.0
Participants: 1
Project status: SIGNED

The limited success of cancer therapy especially in advanced metastatic disease warrants a reassessment, especially given our limited understanding of the nature of cancer cells and the factors that allow them to proliferate and metastasise. Stromal cells of the tumour microenvironment, including fibroblasts, endothelial, immune, adipose and mesenchymal cells, significantly affect cancer cell characteristics and tumour fate; however, their sometimes dichotomous function in high- and low-aggressive tumours has not been thoroughly investigated. Here, we propose to elucidate the largely unknown role of haematopoietic stem and/or progenitor cells (HSCs) on tumour growth and metastases. We found that such cells reside in the tumour niche predominantly in non-aggressive tumours. We hypothesise that cancer cells trigger the differentiation of HSCs into haematopoietic tumour-supporting stromal cells, thereby inducing a phenotypic and functional switch that skews them towards a tumour-promoting phenotype, hence promoting tumour cell aggressiveness and metastases. To test our hypothesis, we will use high-throughput technologies to track the lineage, differentiation and commitment of HSCs during tumour progression. Our specific aims are therefore: (a) To systematically analyse tumour-promoting and tumour-restricting stromal phenotypes at the cellular and molecular levels. (b) To characterise stromal cell plasticity and the contribution of tumour cells to the phenotype switch. (c) To determine whether differentiated stromal cells and HSCs in cancer patients can predict clinical outcome. (d) To screen for molecules that inhibit the tumour-promoting stromal switch. Blocking the tumour-promoting phenotypic switch and maintaining a pre-mature tumour-restricting stromal microenvironment represent a novel strategy in the fight against cancer. This study will lead to the development of new tools to predict prognosis and pharmacological strategies to restrict tumour growth.

Keywords: haematopoietic stem cells,tumor microenvironment,macrophages,myeloid cells,angiogenesis,treatment modalities for cancer,metastasis,biomarkers
Business Innovation Support Network PLUS Enhancing the innovation management capacities (BISONet PLUS4 ENH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Czechia,Czechia,Czechia,Czechia
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 148993.75
EU funding (EUR): 148993.75
Participants: 7
Project status: CLOSED

BISONet PLUS4 ENH project aims at enhancing innovation capacities of Czech SMEs – the Czech SME beneficiaries of the EIC Pilot under H2020 and Czech SMEs with high potential for growth. Consortium implementing the project is composed of two EEN partner organisations – TC AV CR being the coordinator and JIC being a partner of the project. TC AV CR and JIC will deliver both type of services „Key Account Management services for SME Instrument beneficiaries“ and service „Enhancing innovation management capacities of SMEs“. The total number of service packages to be delivered within the BISONet PLUS4 ENH project is 84 – 76 service packages is dedicated for „Enhancing innovation management capacities of SMEs“ and 8 for delivering KAM services to of the EIC Pilot under H2020 (EIC Pathfinder Pilot, EIC Accelerator Pilot) beneficiaries. The tool to be used to identify needs of SMEs and gaps in innovation management will be „smE-MPOWER Business Innovation Roadmap methodology”.

Keywords: enhancing innovation management capacities,smes,eic pilot,sme instrument,key account management
FIGHTING-OFF CORONAVIRUS (SARS-CoV-2) WITH BROAD-SPECTRUM ANTIVIRALS: ESTABLISHING ANIMAL VIRAL CHALLENGE MODEL (Fight-nCoV)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Sweden,Sweden,France,Denmark
Call: Advancing knowledge for the clinical and public health response to the 2019-nCoV epidemic (H2020-SC1-PHE-CORONAVIRUS-2020, 2020)
Start date: 2020-04-01
End date: 2022-09-30
Duration (months): 30.0
Total project cost (EUR): 2807026.25
EU funding (EUR): 2807026.0
Participants: 6
Project status: CLOSED

Project coordinator: Professor Anna-Lena Spetz, MD, PhD, Stockholm University, Sweden Objectives of proposal: Our consortium “Fight-nCoV” will accelerate preclinical development of new broad-spectrum antivirals for inhalation, building on breath-taking ongoing research. We will determine and characterize the antiviral activity and safety of three viral entry inhibitors (oligonucleotide, Macro-I, tweezer) against SARS-CoV-2 in vitro and in vivo. To enable this, we will build capacity for evaluation of antiviral efficacy against SARS-CoV-2 in vitro using viral pseudotypes and wild-type SARS-CoV-2 as well as in vivo in non-human primates. Safety studies will be performed according to OECD GLP guidelines. Expected results: We will establish a SARS-CoV-2 spike pseudotype system allowing a standardized high throughput evaluation of the antiviral activity of candidate drugs. We will have determined the antiviral efficacy of three novel broad-spectrum viral entry inhibitors: oligonucleotide, macromolecular polymers, and molecular tweezers. We will also build capacity for innovation and preclinical evaluation of our broad-spectrum antivirals and vaccines against SARS-CoV-2 by establishing a macaque challenge model. “Fight-nCoV” will provide efficacy data of our drug candidates given intranasally in non-human primates challenged with SARS-CoV-2, enable an early and valuable outcome for stakeholders and the civil society. Timeline of proposal: Ongoing-30 months Key partners: Roger Le Grand, Director animal facility, CEA, France; Urban Höglund, CEO Adlego Biomedical, Sweden; Jan Münch, Professor in Molecular Virology, UULM, Germany; Alexander Zelikin, Associate Professor, formulation expert, AU, Denmark; and Thomas Schrader, Professor of Chemistry, UDE, Germany.

Keywords: sars cov 2,broad spectrum antiviral,macaque,pseudotype virus,preclinical development
Novel Therapeutic Avenues for dynein-related Ciliopathies (TREATCilia)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany,Netherlands
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2022-01-31
Duration (months): 60.0
Total project cost (EUR): 1499545.0
EU funding (EUR): 909667.5
Participants: 3
Project status: CLOSED

Background: Cilia are hair-like, microtubule-based organelles protruding from most quiescent mammalian cells. They play essential roles in cell signalling (primary cilia) as well as movement of fluid (motile cilia). Although individually rare, cilia dysfunction affects up to 1 in 500 people in Europe, significantly reducing quality of life and lifespan due to dysfunction of multiple organs, including the kidneys, liver, heart, brain, retina, airways and the skeleton. To date, treatment is purely symptomatic. Aim and Approach: TREATCilia aims to decipher novel treatment avenues and improve clinical management for dynein-related ciliopathies. Next-generation sequencing based gene identification for dynein-related ciliopathies (ciliary chondrodysplasias and Primary Ciliary Dyskinesia, PCD) is employed to dissect the molecular basis and identify new therapeutic targets. Revealing genotype-phenotype mechanisms and their underlying cell signalling defects provides further insight into potential treatment options. Novel innovative curative approaches include high-throughput substance screening in model organisms such as the green algae Chlamydomonas and mammalian cells specially adapted for this purpose. Impact: Identification of novel ciliopathy genes will not only improve the biological understanding, but also reveal new treatment candidates. Furthermore, scrutinizing the molecular mechanisms of disease yields pharmacological entry points. TREATCilia develops a pre-clinical pipeline towards gene and mutation-specific treatments for hereditary conditions resulting from dynein-related ciliary dysfunction.

Keywords: pediatrics
We are all Ayotzinapa: The role of Digital Media in the Shaping of Transnational Memories on Disappearance (DigitalMemories)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Argentina,Belgium
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-07-01
End date: 2021-12-31
Duration (months): 66.0
Total project cost (EUR): 1444125.0
EU funding (EUR): 1403150.0
Participants: 2
Project status: CLOSED

The project seeks to study the role of digital media in the shaping of transnational memories on disappearance. It investigates a novel case that is in process of shaping: the disappearance of 43 students in Mexico in September 2014. The role of the new media in getting citizens’ attention and in marking a “turning point” was crucial to the upsurge of a counter-movement against the Mexican government and qualifies the event as significant for the transnational arena. The groundbreaking aspect of the project consists in proposing a double approach: a) a theoretical approach in which “disappearance” is considered as a particular crime that becomes a model for analyzing digital memory. Disappearance is a technology that produces a subject with a new ontological status: the disappeared are non-beings, because they are neither alive nor dead. This ontological status transgresses the clear boundaries separating life and death, past, present and future, materiality and immateriality, personal and collective spheres. “Digital memory”, i.e. a memory mediated by digital technology, is also determined by the transgression of the boundaries of given categories b) a multidisciplinary approach situating Mexico´s case in a long transnational history of disappearance in the Hispanic World, including Argentina and Spain. This longer history seeks to compare disappearance as a mnemonic object developed in the global sphere –in social network sites as blogs, Facebook, Twitter and YouTube– in Mexico and the social performances and artistic representations –literature, photo exhibitions, and films– developed in Spain and Argentina. The Mexican case represents a paradigm for the redefinition of the relationship between media and memory. The main output of the project will consist in constructing a theoretical model for analyzing digital mnemonic objects in the rise of networked social movements with a transnational scope.

Keywords: digital memories,disappearance
Towards a novel paradigm for cardiac function assessment from imaging (CardioFunXion)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,France
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EID) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-09-01
End date: 2019-08-31
Duration (months): 48.0
Total project cost (EUR): 1021497.12
EU funding (EUR): 1021497.12
Participants: 3
Project status: CLOSED

Cardiovascular diseases have been defined as a top priority within H2020. Although diagnostic approaches and therapies have drastically improved over the last decennia, effective, validated and auditable tools for the integrated assessment of cardiac function in clinical practice have yet to be developed. CardioFunXion will contribute to a novel paradigm for integrated assessment, combining (image-based) measurements with (model-based) incorporation of physiological knowledge and clinical guidelines. Project outcomes will include validation (improving reproducibility) and integration (simplifying interpretation) cardiac function assessment tools. These novel approaches will be implemented by connecting the imaging industry with the academic and clinical worlds through a combination of four PhD research projects with dedicated training initiatives to develop an inter-sectorial and interdisciplinary culture. The individual research projects are entitled: Longitudinal assessment of function; Fusion of heterogeneous measurements into physiological plausible representations; Open reference databases/tools for multimodal validation of strain; Novel approach for evidence based classification of heart failure etiologies. The consortium is composed of a large Medical Imaging Company (Philips), a University (UPF), and 2 Clinical Centres (IDIBAPS/CHUC), thus encompassing the whole spectrum of relevant multi-disciplinary multi-sectorial Europe-wide expertise. The early stage researchers in the project will thus benefit from a holistic view of the topic and gain first-hand experience in academic, industrial and clinical research and development.

Keywords: cardiac strain imaging,image analysis algorithm validation,image modality simulation,physiological modeling,decision tree learning,data registration
Disruptive Digital Twin solution combining sensor data streams and high accuracy physics-based models to design and monitor large structural assets (Akselos Integra)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Akselos Integra combines our super-fast, physics-based models,1000x faster than anything else in the market thanks to our proprietary Reduced-Basis Finite Element Analysis technology (RB-FEA), with Big Data analytics and sensor data to create a Digital Guardian, an accurate and detailed 3D virtual model of large-scale operational assets. Our complete solution enables a level of detail and accuracy previously unobtainable with conventional digital twin technology, for the design and maintenance of any kind of large infrastructure in the Oil & Gas, Renewable, Aerospace and Transport (air, rail, maritime) industries where predictive maintenance, real-time simulation and asset management are paramount. Akselos Integra reinvents the workflow for structural integrity management and improves its productivity through: - Time saving and scalability: boost in processing speed (a 1000x upgrade), compared to the best-in-class FEA software used by engineers today, while preserving accuracy with a maximum error of 1% for more than 1 billion degrees of freedom. - 24/7 asset monitoring: safety and reliability for large structures by implementing structural health indicators to help operators monitor and manage the integrity and lifecycle of their assets in real-time. To ensure the viability of Akselos Integra we will firstly include a technical analysis to guarantee the expected functionalities and key features in relevant operational environments, and secondly, we will develop a business plan including a commercial and financial feasibility study. Akselos Integra addresses critical needs for design and predictive maintenance in industrial sectors. Thus, Akselos Integra creates a new window of opportunities for the IIoT market by offering the first reliable and real-time physics-based digital twin for predictive maintenance applications. Akselos Integra is a key technology driver for the Industry 4.0 (or IIoT).

Keywords: digital twin technology,smart connected objects,big data,sensor,predictive maintenance,industry internet of things
NEXT-GEN SOFTWARE IN LEGAL DOCUMENTS AUTOMATION (BigleLegal)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Legal systems are critical for a prosper society. From individual to governmental levels, we all are involved in these systems and must deal with a series of legal documents to interact with our administrations, companies and other individuals. Legal documentation can make the difference between a perfectly operative entity and a massive failure. Since the late 90s, IT systems aimed at efficiently manage legal documentation, but they are incapable of satisfying the needs of the modern society. Indeed, up to 75% of entities still elaborate their legal documents manually, which involves several problems: (1) Massive amounts of work hours (around 120 minutes per document); (2) High costs (near €54 per document); (3) Human errors due to the inherent need for human intervention. BIGLE IBERIA S.L. co-founders have realized about this problem and have launched the company in 2016, developing a first version of Bigle Legal Software. Now the company has 18 high-skilled professionals in the legal and technology sector and it is working in the future version of Bigle Legal, which based on advanced techniques of Natural Language Processing (NLP) automates most of the work involved in creating and managing legal documents and applying Artificial intelligence (AI) understands what the document is and what the users want, leveraging much of the repetitive work and leaving them customize the resulting document to match their specific needs. The target users will be initially Law firms, Real Estate companies and Notaries and in future stages it will be extended to in-house legal departments and individual lawyers. BIGLE IBERIA is very well known in the Real Estate and Legal sectors, having engaged relevant clients with worldwide presence. Using Bigle Legal, they will be able to complete a legal document in 10 minutes at a cost of €5 which, for a medium-sized firm it would represent 11,000 man hours and ~€295,000 savings/ year.

Keywords: legaltech,legal documentation,document automation
The wafer thin, flexible, lightweight and endless scalable LED screen for dynamic ambient lighting and outdoor video walls (Digital Wallpaper)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-11-01
End date: 2022-06-30
Duration (months): 32.0
Total project cost (EUR): 3143448.0
EU funding (EUR): 2200413.6
Participants: 1
Project status: CLOSED

There is a huge demand for dynamic, digital displays and lighting solutions of surfaces, indoor and outdoor. Façades, walls, floors, ceilings, not only in/on buildings, but also in the automotive and transportation segment are only some applications. But state-of-the-art solutions are either limited to single colour lighting with no individual control of LED pixels, or they are expensive, heavy, limited in size, shape, curvature and difficult to install. LightnTec is a leading innovator in Europe for light and its control on ultra-thin films and will exploit this business opportunity. LightnTec’s Digital Wallpaper is ultra-thin, malleable, flat, large in scale, applicable both indoors and outdoors, and digital – any size, any shape, any place, ultra-thin, ultra-lightweight. The technology offers wide-ranging application potential in ambient lighting, Human Centric Lighting, and illuminating surfaces on ceilings, walls and façades. With top level management experience from the market leaders like Barco, IMM and Borsi, CEO Florian Kall and CSO Lutz Nehrhoff von Holderberg have a very clear plan for the further development of their product, production upscaling and the commercialisation strategy. The initially addressed ambient lighting, digital signage and LED display markets show a huge potential. The global ambient lighting market with a revenue of 46 billion US$ in 2016 is expected to grow by 10.71% (CAGR 2017–2023). The LED display market generates nearly 3 bn€ and a growth of 20% in Europe due to more and more applications in retail and reduced production costs and market penetration of LED technologies. With a Total Available Market for Digital Wallpaper growing from of 8.7 million m² (2017) to 12.2 million m² in 2024, LightnTec is confident to reach a market share of 17% of the defined SAM with 71,940 m² in 2024. Through sales, rental, and after-sales services, LightnTec anticipates a turnover of 48M€, and an additional staff headcount of 85 employees in 2024.

Keywords: lighting,ambient lighting,stretch ceiling,interior lighting,light on foil,digital lighting,dynamic lighting,human centric lighting