Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unraveling the origin of the Initial Mass Function (COSMIC-DANCE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: France
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 1859413.0
EU funding (EUR): 1859413.0
Participants: 1
Project status: CLOSED

Despite the tremendous progress achieved over the past decade, the study of stellar formation is far from complete. We have not yet measured the minimum mass for star formation, nor the shape of the IMF down to the least massive free-floating planets, or know how universal this shape is. Although clusters are the building blocks of galaxies, little is known about their early dynamical evolution and dispersal into the field. The main culprit for this state of affairs is the high level of contamination and incompleteness in the sub-stellar regime, even for the best photometric and astrometric surveys. COSMIC-DANCE aims at overcoming these drawbacks and revealing the shape of the IMF with a precision and completeness surpassing current and foreseeable surveys of the next 15 years. We will: 1) Measure: using a groundbreaking, proven and so far unique method I designed, we will measure proper motions with an accuracy comparable to Gaia but 5 magnitudes deeper, reaching the planetary mass domain, and, critically, piercing through the dust obscured young clusters inaccessible to Gaia’s optical sensors. 2) Discover: feeding these proper motions and the multi-wavelength photometry to innovative hyper-dimensional data mining techniques, we will securely identify cluster members within the millions of sources of the COSMIC-DANCE database, complemented by Gaia at the bright end, to obtain the final census over the entire mass spectrum for 20 young nearby clusters, the end of a 60-year quest. 3) Understand: by providing conclusive empirical constraints over a broad parameter space unaccessible to current state-of-the-art surveys on the much debated respective contributions of evolutionary effects (dynamics, feedback and competitive accretion) and initial conditions (core properties) to the shape and bottom of the IMF, the most fundamental and informative product of star formation, with essential bearings on many areas of general astrophysics.

Keywords: initial mass function,astrometry,proper motion,brown dwarf,planetary mass object
A Non-Invasive GLUCOse MONitoring device for diabetics based on Stimulated Raman Spectroscopy in a quick, cheap and painless method. (NiGlucoMon)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: United Kingdom
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Today, diabetics must carry out a “finger prick” test as part of their blood glucose level management. It is recommended to do this test at least 4 times a day. Many diabetics fail to do so even once for a number of reasons: pain avoidance, disliking the sight of blood, cost of the test strips, the test protocol and the risk of infection. This failure to manage blood glucose levels has serious long term implications. Heart disease and blood vessel disease are the biggest complications that people with uncontrolled diabetes face. Blood vessel damage or nerve damage also lead to chronic foot and leg ulcers called diabetic foot that can result in amputations. More than 60% of leg and foot amputations not related to an injury are due to diabetes which is also the cause of new blindness and kidney disease. Our solution is a non-invasive glucose monitor that will allow people with diabetes to monitor their blood glucose levels in a quick and painless manner, for a low price. When using normal Raman Spectroscopy very little light undergoes Raman scattering, therefore high integration times are required to achieve a usable signal-to-noise ratio. Expensive optics are necessary for collecting, isolating and dispersing the light. Our technique and system packaging promises to overcome all of these obstacles. We use Stimulated Raman Spectroscopy, created when two light beams interact with each other in the presence of glucose. The energy is transferred from one beam of light to the other, and this transfer is proportional to the number of glucose molecules present. By measuring this energy transfer using a simple and inexpensive power meter, the glucose concentration is measured without the need for dispersing the light and analyzing the Raman Spectrum. A patent has been applied for. We have completed the Technology Readiness Level 2 (technology concept formulated) and plan to complete Technology Readiness Level 3 (Experimental Proof of concept) in this project.

Keywords: diabetics,non invasive monitoring,improved disease management,reduction of health care costs,handheld device for home use
The HUB for boosting the Responsibility and inclusiveness of ICT enabled Research and Innovation through constructive interactions with SSH research (HubIT)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Coordination and support actions
Countries involved: Germany,Estonia,Italy,Israel,Lithuania,Slovakia,Hungary,Slovakia,Denmark,United Kingdom,Portugal
Call: Boosting inclusiveness of ICT-enabled research and innovation (H2020-SC6-REV-INEQUAL-2017, 2017)
Start date: 2017-09-01
End date: 2021-02-28
Duration (months): 42.0
Total project cost (EUR): 2999750.0
EU funding (EUR): 2999750.0
Participants: 14
Project status: CLOSED

The long term strategic objective of HubIT is to contribute to the high level of European research and innovation and ensure that H2020 funded and further ICT related innovation is responsible, inclusive and aimed at reversing inequalities. The direct objective of HubIT is to build a hub that will activate and improve constructive and co-creating interactions between SSH and ICT disciplines in developing and implementing a shared vision of inclusive HubIT will activate constructive interactions between the stakeholders forming the RRI-SSH eco-system via various network and engagement activities embedded intro the WP structure, that have the overall goal of developing a tangible European Framework Model for implementing responsible and inclusive ICT research and innovation. The Framework Model is a comprehensive set of jointly developed and used definitions, guidelines and tools for enforcing RRI and SSH issues in ICT research and innovation: • The concept of responsible R&I • Matrix of the key challenges • Tool for assessment of RRI and SSH perspectives in ICT within an organisation • Guidelines for responsible ICT R&I informed by SSH • Best Practice Repository • Fact Sheets and Policy briefs • Key measurable success indicators • Policy Recommendations • Virtual Matching Catalogue • HubIT exploitation plan The mechanisms for network building, engagement and awareness rising embedded in the WP structure are: • Advisory Board workshops • Expert Group workshops • Community building and knowledge sharing – national network events, thematic workshops, policy, SSH researchers and ICT industries workshops • Practical collaborations and experimentation - Common Ground Camps, Interactive ICT Labs, Inclusive Hackathons In total 35 network activities are implemented and in total 1140 participants. HubIT online platform will be the interactive environment, where the project tools and services can be accessed in modular, visually attractive and dynamic way.

Keywords: responsible research and innovation,ict research and innovation,responsibility and inclusiveness,social sciences and humanities
A novel universal influenza vaccine targeting epitopes of limited variability (UNIFLUVAC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-10-01
End date: 2020-03-31
Duration (months): 18.0
Total project cost (EUR): 149297.0
EU funding (EUR): 149297.0
Participants: 1
Project status: CLOSED

The antigenic evolution of influenza is conventionally assumed to occur by ‘antigenic drift’ where new strains arise through the incremental addition of mutations in surface glycoproteins. However, the antigenic drift model can only explain the epidemiology and limited genetic diversity observed among influenza virus populations by imposing constraints on the mode and tempo of mutation. We have shown that an alternative model known as ‘antigenic thrift’ successfully models the epidemiology and genetic diversity of influenza by assuming that the antigenic evolution of the virus population is primarily driven by natural immune responses against epitopes of limited variability. We have identified epitopes of limited variability in H1, H3 and influenza B. Each epitope has between 3 and 4 different conformations. These epitope conformations are all in the head domain of the HAs of various subtypes, making them naturally highly immunogenic. The epitope are also limited in variability, often due to their position adjacent to the receptor binding site, cycling through their limited repertoire of conformations as host population immunity changes. By vaccinating against these epitope conformations for each subtype, we can induce immunity against all past and present H1, H3 and influenza B. This approach will remove the need to vaccinate each year and have much higher levels of efficacy. The vaccine can also be made using the established methods of inactivated or attenuated influenza vaccine production. This maintains a price threshold of 5 USD per dose, making the vaccine attractive to pharmaceutical companies, and by reducing the number of doses required to confer immunity and while maintaining production cost, the vaccine is attractive to healthcare providers.

Keywords: influenza,vaccine,evolution,biotechnology,interdiscpinary,novel
Whole-brain circuits controlling visuomotor behavior (NEUROFISH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Portugal
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-02-01
End date: 2024-07-31
Duration (months): 78.0
Total project cost (EUR): 1694063.0
EU funding (EUR): 1694063.0
Participants: 1
Project status: SIGNED

Understanding how our brains extract relevant features of sensory input to select and guide appropriate actions is a fundamental goal of neuroscience. Yet even relatively simple sensorimotor reflexes can depend on activity within complex networks of neurons that are distributed across the brain, presenting a challenge for traditional neuroscience approaches. Our recent work has demonstrated the capacity to image neural activity with single cell resolution throughout the small transparent brain of behaving zebrafish. Here we will trace, from sensory input to motor output, the neural circuits that allow zebrafish to select and execute distinct swimming patterns in response to varying visual input. Through comprehensive whole-brain functional imaging in combination with optical and genetic circuit tracing, we aim to determine the principles on which these sensorimotor circuits are organised and reveal how activity dynamics unfold throughout the whole brain during behaviour. We will take a systematic approach to this problem, based on a thorough quantitative analysis of swim kinematics and the sensory stimuli that drive them. We will: 1) Use whole-brain functional imaging of genetically defined neural populations to reveal the neural circuit organization and activity dynamics during visuomotor behaviour. 2) Establish how motor commands are encoded at the single-cell and population level by brainstem reticulospinal neurons, through imaging and ablation studies and 3) Systematically map the functional organisation of retinal inputs into the brain. Taken together, these experiments will provide an unprecedented, single-cell resolution view of the organization of complete circuits that transform retinal inputs to motor outputs in the vertebrate brain.

Keywords: circuit neuroscience,zebrafish,sensorimotor integration,locomotion,vision,calcium imaging
Targeted Cell Recruitment During Organogenesis And Regeneration: Glia Makes The Tooth (STEMMING-FROM-NERVE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Austria
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-08-01
End date: 2020-09-30
Duration (months): 62.0
Total project cost (EUR): 1964338.0
EU funding (EUR): 1964338.0
Participants: 1
Project status: CLOSED

Recently we discovered an entirely new phenomenon in developmental biology – targeted recruitment of stem cells from the pervasive peripheral nerves. For example, we demonstrated that majority of melanocytes – our pigment cells, are born from peripheral glial cells. To further extend this far-reaching principle we will use tooth development as a model. Current opinion holds that sensory innervation of the tooth has a minor or no role in making a structure of the tooth during development and adulthood. On the contrary, our preliminary data strongly suggest that sensory nerve contributes pulp cells and matrix-producing cells of odontoblast lineage to the growing tooth. Our hypothesis implies that nerve-associated glial cells can be recruited from the nerve by unknown molecules presented inside of the tooth environment, and that these recruited cells are capable of producing pulp cells and odontoblasts. WE PROPOSE TO ADDRESS THE ROLE OF A SENSORY NERVE AS A PROVIDER OF DENTAL STEM CELLS DURING THE DEVELOPMENT, ADULTHOOD AND REGENERATION. To experimentally address our hypothesis we developed innovative and powerful approaches: we will use advanced genetics tracing with multicolor reporters, completely novel unconventional individual cell transcriptome analysis, transgenic mice with cell type-specific modifications in signaling, microsurgery and grafting, and, finally, 3D-imaging of developing tooth structures. This project is interesting to a wide community of scientists because it addresses a novel function of peripheral nervous system which is contributing stem cells as building blocks to local tissues in development and regeneration. The MEDICAL IMPLICATION of this project will include better understanding of tooth regeneration providing new approaches to dentin recovery and tooth restoration following trauma.

Keywords: peripheral nerves,schwann cells precursors,multipotency,tooth development,cellular lineage,genetic tracing,control of differentiation
The Effects of Media News about Immigrants on Majority’s Attitudes and Behaviors towards Immigrants (IMMIGRANTS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2019-07-23
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

The interdisciplinary IMMIGRANTS project aims at a better understanding of how media influence majority’s attitudes and behaviors towards immigrants – a socially pressing issue connected to rapid expansion of immigration in Europe. In the project, I will focus on different aspects of media news – their valence, labels used for immigrants’ ethnicity and pictures of immigrants accompanying media articles about immigrants. The first goal of my research is to investigate how different labels used for immigrants’ ethnicity (nouns vs. adjectives) combined with different valence of media articles about immigrants (positive vs. negative vs. ambivalent) influence participants’ attitudes and behaviors towards immigrants. My second goal is to compare the effects of articles accompanied by different images of immigrants and articles without such images on participants’ attitudes and behaviors towards immigrants. Both goals feature a number of tasks related to the effects of media articles on attitudes and behaviors towards immigrants: I will test underlying mechanisms (e.g., biometrically tracked positive and negative emotions) and boundary conditions (e.g., social status and category salience of an immigrant group, participants’ intergroup contact with immigrants) of these effects. In three studies of the IMMIGRANTS project, I bring together different traditions on media and immigrant research and address several gaps in social scientific literature (e.g., too narrow focus on negative media news in political and media research, too narrow focus on positive intergroup contact and self-reported emotions in psychology). The outcome of IMMIGRANTS can be used to inform guidelines for professional training of journalists, policy makers, and social workers to become more sensitive to the impact of language describing immigrants.

Keywords: immigrants,media,linguistic forms,attitudes,emotions,intergroup contact
Microfluidic Active Pharmaceutical Ingredients Capture (MAPIC) System (MAPIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

This project aims at tackling pharmaceutical micropollutant capture (antibiotics, endocrine disruptors,…) from wastewater by developing a small, energy-efficient, high capture efficiency device that couples microfluidic technology with β-Cyclodextrin polymer (β-CDP). β-CDP was recently shown to outperform all other adsorbants in water depollution test. Yet, like all adsorption methods, β-CDP efficiency is dependent on required elapsed time for interaction events to occur in between flowing pollutant and the adsorbant surface. This can be greatly improved by using microfluidics systems which reduce drastically both the diffusion distance and the related time while significantly minimizing the overall footprint. The proposed highly integrated microfluidic architectures target to treat up to 50 m3/day, and unlike conventional methods uses minimal energy (<200Pa). The modular assembly will also enable multiplexed capture approaches through serial configuration. This project will pave the way towards further possibilities for applications in biosensing, solvent recovery, and others fluid system remediation (Air, Gas, oils, etc,…). With the support of Blackholelab and its owned IP, two remediation demonstrators will be realized for domestic and industrial perspectives, with respectively targeted sizes of a Soda-Can and a suitcase. This innovative solution to remove pharmaceuticals from wastewater can help in tackling some of our greatest challenges: water scarcity, energy saving, and antibiotic resistance.

Keywords: microfluidics,cyclodextrin
Targeting Glioblastoma using Combinatorial Therapeutic Nanovaccine (GLIOMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-02
End date: 2019-10-01
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The proposal aims at the synthesis, characterisation and application of a novel therapeutic nanovaccine (TNVax) that holds multiple modules for targeting glioblastoma multiforme (GBM). The proposed TNVax formulation includes a gold nanocage core encapsulating Temozolamide (TMZ), coated with an extremophilic bacterial polysaccharide, mauran functionalised with anti-PD-L1 antibody and anti-CD133 antibody. The us of NVax nanoparticles (NPs) offers a combinatorial approach in killing GBM cells both by immuno- and chemo- therapeutically. Site-specific delivery of the payload will stimulate the host immune system and channel the immune cells to the target site. Functionalisation of the anti-PD-L1 antibody on drug-encapsulated NPs would significantly alter the immune suppression caused by GBM cells on TNVax delivery. In addition to anti-PD-L1 antibody, the TNVax particles contain tumour specific monoclonal antibody that specifically recognizes CD133 antigen and facilitates strong binding. This approach would enhance the amount of antitumour activity offered by multiple means and thereby leaving a strong immune response against GBM based on antigen-antibody interactions. TNVax NPs will be synthesised and characterised using microscopic and spectroscopic techniques and then subjected to in vitro and in vivo evaluations. In vitro studies will be performed for drug release kinetics and cytotoxicity using immunofluorescence and FACS analysis. Induction of immune response by TNVax NPs will be evaluated using macrophage activation, induction of T-cell activity and cytokine production under in vitro conditions. The pharmacokinetic and pharmacodynamic studies will be carried out and histopathological examinations performed using appropriate murine models induced with GBM cell lines. The potential outcomes of the proposed studies will help patients who suffer from early and advanced GBM by eradicating the disease permanently and leaving good immunological memory.

Keywords: nanovaccine,cancer therapy,immunotherapy,theragnostics,glioblastoma,gold nanocages