Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Smart Multifunctional silica-based Nanoparticles for Targeted Therapy (NanoSil4Cancer)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Italy
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-09-01
End date: 2017-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

NanoSil4Cancer project will be able to accelerate the uptake of nanotechnologies, by developing, mesoporous silica-based prototypes of nano-vehicles, according to an innovative and proprietary approach (EP06745236), active in smart chemotherapy. This is aimed to minimize toxicity and the side effects of the traditional antitumor agents and to increase their therapeutic potential. This technology platform enables customers’ molecules to be formulated as pH–sensitive pro-drugs and introduced in smart nanoparticles able to reach the intracellular compartments of cancer cells where the drug is released. Development of new prototypes will lead to new patent applications. Recently we have developed and optimized a device, provided with folic acid, able to manage bortezomib release in cancer cells overexpressing folate receptor, FR (PCT-13511). The nanoparticles are only recognized and internalized by FR overexpressing cancer cells, where they release the drug, sparing normal cells. Nevertheless, our technology is general, not limited to a specific prototype, but depends on customer's needs, market and final users' needs. The feasibility study will individuate strategical market interests to address the prototypes production as business opportunities for our SME. Market trend and the role of Big Pharma will be defined to identify commercial partners and stakeholder to be involved in the project. We will buy sectorial report, we will use patent search such as EPO and Thomson, we will acquire missing competence in marketing and communication. The approach will represent a strong step forward in chemotherapy, improving the efficacy, lowering drug dosage (thus minimizing side effects for cancer patients and environmental impact), other than dramatically lowering EU Healthcare costs (up to 80-90% saving on non-adherence to the therapy costs, estimated in $290B/year), allowing Europe to increase its attractiveness in the field of innovative medical technologies.

Keywords: targeted therapy,cancer,drug targeting,mesoporous silica nanoparticles
Architectured Soft Magnetoactive Materials: Beyond Instabilities (MAGIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Ireland,Italy
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 1999085.0
EU funding (EUR): 1999085.0
Participants: 2
Project status: SIGNED

Soft magnetoactive materials can change their properties and undergo extremely large deformations when excited by magnetic stimuli. These reconfigurable soft materials hold great potential for a large variety of applications from sensing devices to energy harvesting, noise and vibration mitigation, and soft robotics. However, these materials operate at high magnetic fields, thus, limiting potential application of the technology. A promising approach to significantly enhance the magnetomechanical performance, and reduce the required magnetic field, is to design soft magnetoactive composites through architectured microstructures. Highly ordered microstructures are an origin for multiscale magnetomechanical instabilities and possible failure of the materials. In this research proposal, we directly address this crucial aspect for MAE-based technology. Moreover, we declare an ambitious goal: Turning failure into functionalities. Our strategy is to take the risk of operating MAEs in the unstable regime with predesigned instability developments. This novel MAE design concept will capitalize on controllable cascade microstructure transformations while attempting to avoid catastrophic failure. If successful, this concept will open a new avenue in design of morphing magnetoactive materials with new functionalities and superior performance. To achieve this ambitious goal, we will develop multiscale theoretical and computational frameworks to reveal and to predict the behavior of possible advantageous microstructures in the extreme regimes. If successful, we will fill the gap in magnetomechanical multiscale instability phenomena, and will significantly advance the frontier of knowledge about the reconfigurable soft matter. We will probe our ideas experimentally, and will fabricate the revealed advantageous materials with engineered microstructures and properties. We envision revealing the fundamental multiphysics mechanisms of the multiscale magnetomechanical instabilities.

Keywords: soft materials,instabilities,magnetoactive materials,microstructures,3d printing
Smart Human Oriented Platform for Connected Factories (SHOP4CF)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Spain,Germany,Germany,Spain,Finland,Poland,Türkiye,Poland,Belgium,Finland,Greece,France,Netherlands,Luxembourg,Denmark,Denmark
Call: Digital Manufacturing Platforms for Connected Smart Factories (H2020-DT-2019-1, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 16171592.15
EU funding (EUR): 15008467.0
Participants: 23
Project status: SIGNED

SHOP4CF aims to find the right balance between cost-effective automation, repetitive tasks and involve the human workers in areas such as adaptability, creativity and agility where they create the biggest added value. Also to pursue the highly-connected factory model to reap the benefits of all the data generated within the factory. Tapping into those data streams and human capital requires creating favorable technological, economical and societal conditions. SHOP4CF will do so by relying on the following: • A platform developed on an open architecture encompassing technologies based on RAMI 4.0 and FIWARE Technologies which can support humans in production activities and providing basic implementation as a free, open-source solution. Including 30 components developed within SHOP4CF project by top RTOs from all over Europe. • Implementing pilots acting as the testing facilities and seeds for adoption of the platform. 4 large scale pilots lead by industrial leaders in Europe and 30 FSTP Pilots selected through 5 competitive open calls that will receive technical, business and access to investment support. • A marketplace as one-stop-shop for SMEs (developers and end users) to access essential services for digital transformation including business modelling, technical support, access to skills and finance. • Building a vibrant and growing community around the platform necessary to create the adoption critical mass. • Leading pre-standardization activities in the areas of collaborative robotics, AGVs and use of IoT devices on the shopfloor. SHOP4CF will continue its operations with a self-sustainable non-profit association with members all over Europe that could be integrated with the one created by DIH2 project. SHOP4CF will demonstrate that public funded research can help SMEs & Mid-Caps achieve digital excellence and global competitiveness through adopting advanced robotics solutions in human-centric digitalization

Keywords: robotics,digitalization,virtual reality,augmented reality
PROTEIN TYROSINE PHOSPHATASES IN METABOLIC DISEASES: OXIDATION, DYSFUNCTION AND THERAPEUTIC POTENTIAL (METAPTPs)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-04-01
End date: 2025-03-31
Duration (months): 72.0
Total project cost (EUR): 1966906.0
EU funding (EUR): 1966906.0
Participants: 1
Project status: SIGNED

Diabetes mellitus is characterised by hyperglycaemia caused by an absolute or relative insulin deficiency. The global prevalence of diabetes has reached more than 410 million individuals, underscoring the need for novel therapeutic strategies targeting the pathology as a multi-organ disease. Protein tyrosine phosphatases (PTPs) constitute a superfamily of enzymes that dephosphorylate tyrosine-phosphorylated proteins and oppose the actions of protein tyrosine kinases. My previous studies and preliminary data suggest that PTPs act as molecular switches for key signalling events in the development of diabetes, i.e. insulin/glucose/cytokine signalling. Dysregulation of these pathways results in metabolic consequences that are cell-specific. Oxidative stress abrogates the nucleophilic properties of the PTP active site and induces conformational changes that inhibit PTP activity and prevent substrate-binding. I have recently developed an innovative proteomic approach to quantify PTP oxidation in vivo and demonstrated that this occurs in liver/pancreas under pathological conditions, including obesity and inflammation. In this proposal, I aim to fully characterise the activity and oxidation status of PTPs in dysfunctional metabolic relevant cells in obesity and diabetes. Importantly, the crucial role of PTPs make them promising candidates for the treatment of metabolic disorders. I hypothesise that specific antioxidants, diets and/or adenovirus will restore PTP function and ameliorate the metabolic deleterious defects in pre-clinical studies. Over the next 5 years, I aim to: • Identify the major oxidised PTPs in metabolic relevant tissues/cells in both obesity and diabetes. • Determine the contribution of PTP inactivation in cellular responses to metabolic signalling in human samples. • Assess the impact of tissue-specific PTP deficiency on the development of obesity and diabetes. • Test novel therapeutic approaches targeting PTPs to prevent/reverse metabolic disorders.

Keywords: protein tyrosine phosphatases,diabetes,insulin signalling
Recognition-encoded synthetic information molecules (InfoMols)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2499850.0
EU funding (EUR): 2499850.0
Participants: 1
Project status: SIGNED

Linear oligomers encoded with a sequence of side-chains that have specific recognition properties are the basis for a range of properties that are the hallmarks of Nature’s nanotechnology: folding, substrate recognition, catalysis, self-assembly, and molecular replication. Nucleic acids are currently unrivalled as the only molecular architecture that embodies all of these properties, and this ability to encode, express and replicate sequence information is the molecular basis for the evolution of life on Earth. The aim of this proposal is to develop synthetic oligomeric molecules that encode and express chemical information in the same way as nucleic acids, via a sequence of recognition sites attached as side-chains to a linear backbone. We have already reported a range of synthetic oligomers that bear no relation to the structures of their biological counterparts, yet show efficient sequence-selective duplex formation via H-bonding interactions and can be used for replication of sequence information via covalent base-pairing interactions. Here hybrid systems are proposed that combine the most successful elements of backbone architecture and oligomerisation chemistry with a mixture of dynamic and kinetically inert base-pairing side-chains to obtain new synthetic systems that show all of the functional properties found in biomolecules. The ability to replicate sequence in recognition-encoded synthetic information molecules will enable exploration of new chemical spaces using directed evolution. These new chemical systems will allow us to evolve synthetic oligomers that fold into stable well-defined 3D structures, bind substrates with high affinity, and catalyse reactions. Programmable abiotic molecular nanotechnology will open a new area of chemistry with huge unexplored potential.
Body-Politics: Personhood, Sexuality, and Death in the Iron and Viking Ages (BODY-POLITICS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1499492.0
EU funding (EUR): 1499492.0
Participants: 1
Project status: SIGNED

The overall objective of BODY-POLITICS is to provide an original and creative analysis of body-politics and personhood in first millennium Northern Europe. It is the first large-scale research project that seeks to understand political development through the battleground of the body and through the construction of the person in the Scandinavian Iron and Viking Ages. BODY-POLITICS will break new ground in combining cutting-edge natural science methods (aDNA, isotope analyses, osteobiography) with core social and philosophical concerns. The project will moreover provide problematizing research on challenging topics: sexual assault, subalterns as non-persons, and ritual violence, in an era that is frequently romanticized and has never seen more popular attention. Through an interdisciplinary research programme, the body will be centred as a political medium targeting three core themes: personhood, sexuality, and death. To operationalize the overall objective, BODY-POLITICS will conduct ground-breaking analyses of five interlinked datasets: 1) a never-before studied database of bodies deposited in settlements in the first millennium; 2) an in-depth study of infants, who are situated between sentient object and full social persons; 3) a novel dataset of sexuality and sexual violence in texts and things; 4) body imagery as it exposes body concepts; and 5) textual evidence of distinctions in personhood. In combination, these analyses provide glimpses of radically diverse concepts of the body: of ‘proper’ death, of sexuality as an instrument of violence and medium for power, of complex interplay between bodies and body imagery, and of blurring between bodies as social subjects and meaningful objects. Ultimately, the question of who could be a person in Iron and Viking Age Scandinavia is not marginal but integral to understand social and political development. It is a question that would – through migrations, raids, and violence – fundamentally shape the history of Europe.

Keywords: personhood,the body,iron age,viking age,mortuary ritual,ritual deposition,sexuality in the past,childhood in prehistory,body imagery,old norse literature,bioarchaeology,adna
Increasing the efficiency of LED street lighting by 15% via optical design (PearlLight+)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Hungary
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-2-2015, 2015)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 2439690.0
EU funding (EUR): 1707783.0
Participants: 1
Project status: CLOSED

About 60% of the electricity costs for a municipality is street lighting. Recently, the wider deployment of innovative LED lighting solutions has been made a priority by the European Commission. The main area where LED-based street lighting can be improved is the light throughput efficiency of the lens and the transparent cover of the luminaire. Hungaro Lux Light Kft. has developed a novel design method for manufacturing LED lens and covers optimised to the desired illumination pattern and the specific LED chip used. This optimisation improves light throughput by 15% on average compared to currently available lens. The software and production technology development to be undertaken in this Phase 2 project are the last major steps before the market introduction of the technology. This innovation will enable our company to provide a new range of highly competitive luminaries, strengthening our position in key international markets and increasing our turnover significantly.

Keywords: led lighting,outdoor lighting,optics,software,optimisation,nanocoating,design
Towards middle-range theories of the co-evolutionary dynamics of multi-level social-ecological systems (MUSES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2017-02-01
End date: 2023-01-31
Duration (months): 72.0
Total project cost (EUR): 1969599.0
EU funding (EUR): 1969599.0
Participants: 1
Project status: SIGNED

Humans have the capacity to change the biosphere from local to global scales while at the same time fundamentally depending on a functioning biosphere for their well-being. Moreover human societies are increasingly affected by global change and adapting to it in multiple ways. These interdependencies give rise to non-linear, cross-scale dynamics that pose significant challenges for analysis and governance of social-ecological systems (SES). In view of the need for societal transformations towards sustainability is the identification of mechanisms of change in SES an urgent and cutting-edge research frontier. This project aims to develop new methodologies and middle-range theories of the dynamics of SES. It will take the nature of SES as complex adaptive systems into account by developing a mechanism-based understanding of change in SES as it arises from micro-level interactions within complex networks of actors and ecosystems. Particular emphasis will be put on emergent and top-down cross-scale interactions. To this end we will develop dynamic multi-level models using agent-based and mathematical modeling approaches. Model development will be based on a typology of cross-scale interactions, theories from the natural and social sciences and empirical evidence from marine and terrestrial SES. We will combine stylized with empirically-based models and cross-case comparison to develop a typology of social-ecological configurations of the long-term persistence of SES and their capacity to change. Knowledge integration across disciplines and the development of integrative frameworks and approaches will be supported by procedures to bridge different ontological and epistemological foundations. The project will advance sustainability science by providing new methods for modeling multi-level SES and cross-scale interactions, and approaches to identify and include critical social-ecological interactions, particularly human adaptive responses, into models of SES.

Keywords: social ecological interactions,ontology and epistemology,knowledge integration,cross scale dynamics,ecology,complexity
Smartphone-based Mobile Positioning System (SmartPosition)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-02
End date: 2017-11-01
Duration (months): 18.0
Total project cost (EUR): 127591.2
EU funding (EUR): 127591.2
Participants: 1
Project status: CLOSED

This project aims to develop two new estimation paradigms for designing a reliable, high precision and real-time mobile positioning system (MPS): clustering for filtering (C4F) and fitting for smoothing (F4S). The present MPS faces two immediate challenges from the real life world. First, little is known about the background and therefore accurate system modelling is difficult or even impossible and the use of conventional filters/smoothers is challenging or even infeasible. Secondly, the data is very rich in the sense that it comes from multiple and many types of sensors with improved scanning frequency and accuracy. The rich sensor data can be used to circumvent poor background knowledge and to provide a greater breadth of observation regardless of individual sensor failure. However, it is expected that rich data will also pose a great challenge for real time filtering implementation. This project will develop a new concept, “Big Sensor”, to flexibly utilize the rich time-varying sensor data in the concerned MPS and to implement C4F and F4S. The Big Sensor-based C4F and F4S use all available information including WIFI, Bluetooth, GPS signals as well as altitude, acceleration, and direction information based on embedded software to locate mobile devices. The resulting MPS will not rely on sophisticated filters and will therefore be more reliable and computationally faster. The research emphasis of the project will be on flexible and optimal sensor data inference which is found by developing novel clustering and fitting algorithms. The researcher and the partitioning organizations have synergic expertise and solid research track records in the related fields. Smartphone-based realistic MPS applications (apps) will be developed, with the potential use of European GNSS. The resulting MPS and its apps will be integrated into a Home Care system that the Host group has investigated for the purpose of tracking the movement and well-being of elderly/disabled people.

Keywords: mobile positioning system,bayesian filtering,localization,tracking,intelligent systems