Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Safeguarding Migratory Fish and their Habitats in the Danube River Basin and beyond (DANUBElifelines)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Austria,Netherlands,Hungary,Germany,Serbia,United Kingdom,Romania,Spain,Bulgaria,Slovakia,Slovenia
Call: Danube river basin lighthouse – Protection and restoration of migratory fish habitats (HORIZON-MISS-2024-OCEAN-01, 2024)
Start date: 2025-05-01
End date: 2029-04-30
Duration (months): 48.0
Total project cost (EUR): 7879518.75
EU funding (EUR): 7796074.0
Participants: 41
Project status: SIGNED

DANUBE_lifelines supports the objective of the Mission ‘Restore our Ocean and Waters’ to protect and restore marine and freshwater ecosystems and biodiversity. The key components of the project include knowledge creation, demonstrating effective solutions, as well as co-creation with stakeholders. The project generates new insights and perspectives on fish migration, habitat quality, and migration corridors improving the status of migratory fish species in the Danube River Basin. It demonstrates measures for protecting and restoring habitat availability, accessibility, and connectivity by removing barriers and pressures and implementing nature-based solutions. Engaging with local actors and national stakeholder groups, conducting training and communication activities, and developing an action plan and roadmap for the replication and scale-up of solutions are also integral parts. DANUBE_lifelines is based on a transboundary, multi-scale and -actor approach that covers several relevant migratory fish species. A basin-wide approach highlights the restoration and conservation needs of migratory fish and their habitats across the Danube River Basin. Furthermore, the project provides a portfolio of solutions for different river sections, including tributaries of the Danube, tailored to local needs and conditions covering the Upper Danube, the Middle and the Lower Danube/Delta. In these regions, integrated approaches are pursued, demonstration activities are learned from and applied, and the conservation of species such as Danube salmon, Pontic shad and sturgeons is improved. Key outputs include the Danube Fish Migration and Connectivity Atlas, identification of hotspot and strict conservation areas for migratory fish, efficiency of restoration measures, mapping the contribution of the Danube Basin to the 25,000 km free-flowing rivers target, an action plan for habitat restoration and conservation, and guidelines and recommendations for replicability.

Keywords: threatened fish species,fish migration,connectivity
ACHIEVE: Development of an oral ACG-based treatment to combat obesity, maintain long-term dieting success and improve metabolic health (ACHIEVE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-09-01
End date: 2027-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Obesity constitutes an alarming global epidemic, exposing billions of individuals to a multitude of metabolic, infectious, & neoplastic health ramifications. While weight reducing interventions of the GLP-1 family are transforming medical weight reductive therapy, long-term weight loss maintenance remains a daunting unmet challenge, with most medically treated individuals rebounding to obesity. In our project, we will generate a first-of-its kind solution to this global need that will involve oral human utilization of microbiome-modulated weight-regulating interventions. In our ERC-funded project (Fluhr et al., Nature 2021), we discovered that depletion of several microbiome-modulated metabolites drives weight gain in smoking-cessation-induced weight gain. Oral supplementation of several of these molecules has led to a generalizable & significant weight reduction across multiple obesogenic conditions. Building on these findings, the ERC-PoC will develop a commercial metabolite-based treatment or supplement, that will safely attenuate weight gain, maintain long-term weight reducing impacts, and improve metabolic functions. The project includes four work packages: (1) Development and production of metabolite-based drugs and/or medical foods (following a rigorous market study in a dual path approach). (2) Testing these molecules for efficacy, mechanism and safety in obese/lean mice. (3) performing a first-in-human trial (using the most efficacious formulation) in obese/GLP-1-treated individuals (4) in parallel, conducting an extensive commercialization effort to translate our findings into a NewCo, based on 1-2 new products. Notably, there is currently no such orally administered long-term solution complementing weight-reducing therapies in maintaining weight over time. As such, our ERC-PoC project will provide a proof-of-concept product/s for prevention & treatment intervention, providing a unique and commercially scalable solution to an important unmet global problem.
Innovative Transactive Renewable Energy Communities (INNO-TREC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Portugal,Italy,Greece,Spain,France,Slovenia,Belgium,Finland,Ireland,United Kingdom
Call: Innovative, Community-Integrated PV systems (HORIZON-CL5-2024-D3-02, 2024)
Start date: 2026-01-01
End date: 2029-06-30
Duration (months): 42.0
Total project cost (EUR): 5360894.0
EU funding (EUR): 4999994.0
Participants: 22
Project status: SIGNED

INNO-TREC brings together a group of preeminent energy industry and research partners focused on revolutionising the RECs sector. It is fully aligned with the EU’s vision for the energy transition as it proposes to develop the next generation of tools, methodologies and platforms that really work for RECs. These advancements will be fully tested and demonstrated in 6 DEMOs in 6 countries (Portugal, Greece, Belgium, Ireland, UK and Italy). INNO-TREC will address the barriers, motivations and drivers from energy users' perspective, intertwining the new technological developments with SSH expertise, thus producing high-level TRL 6-7 innovative results by the end of this project.

Keywords: renewable energy communities,photovoltaic systems,transactive energy,digital tools,markets
Trustworthy Planning and Scheduling with Learning and Explanations (TUPLES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: France,Belgium,Germany,Italy,Netherlands,United Kingdom,Czechia
Call: Verifiable robustness, energy efficiency and transparency for Trustworthy AI: Scientific excellence boosting industrial competitiveness (AI, Data and Robotics Partnership) (RIA) (HORIZON-CL4-2021-HUMAN-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 4200886.25
EU funding (EUR): 4200886.25
Participants: 9
Project status: SIGNED

Planning and scheduling (P&S) is a core area of AI. Its aim is to build systems that assist humans in planning, organising and optimising courses of action to achieve complex objectives. Despite the pressing need for decision-support systems for P&S applications in industry and public services, current approaches do not satisfy essential properties of trustworthy AI, such as transparency, explainability, robustness, safety and scalability. TUPLES is a 3 year project aiming to obtain scalable, yet transparent, robust and safe algorithmic solutions for P&S. The cornerstones of our scientific contributions will be (1) combining symbolic P&S methods with data-driven methods to benefit from the scalability and modelling power of the latter, while gaining the transparency, robustness, and safety of the former and (2) developing rigorous explanations and verification approaches for ensuring the transparency, robustness, and safety of a sequence of interacting machine learned decisions. Both of these challenges are at the forefront of AI research. We will demonstrate and evaluate our novel and rigorous methods in a laboratory environment, on a range of use-cases in manufacturing, aircraft operations, sport management, waste collection, and energy management. Our results also include practical guidelines derived from the lessons learnt in this process, and open-source software tools and test environments enabling the human-centered development and assessment of trustworthy P&S systems. Expected outcomes include increased productivity, decreased environmental footprint and the empowerment of workers in the above sectors. These could translate into huge economic, environmental and social impacts if trustworthiness ends up driving mass adoption of P&S. The TUPLES consortium includes world-leading researchers in several fields of AI (P&S, constraints, machine learning, explanations), humanities and social sciences (psychology, law, ethics), and experts of their applications.

Keywords: planning and scheduling,trustworthy ai,robustness,safety,explainability,hybrid data driven symbolic ai,decision support sytems,verification
The role of microbes in the fate of nanoplastics in the marine realm (NanoMare)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 3499999.0
EU funding (EUR): 3499999.0
Participants: 2
Project status: SIGNED

Nanoplastics (plastic litter fragments <1µm) were only recently discovered in the marine realm. Due to their colloidal nature, nanoplastics may be dispersed throughout the ocean, potentially affecting all marine life. However, their minuscule size has made it virtually impossible to measure their distribution or determine if microbes can degrade nanoplastics, thus influencing their fate in the ocean. Innovative approaches developed by my team have now made this possible for the first time. Using an ultrasensitive mass spectrometry method, our preliminary results revealed substantial concentrations of various nanoplastic types in both surface waters and the deep sea, suggesting that nanoplastics could constitute an important part of the ocean’s plastic budget. Simultaneously, results from a novel stable isotope assay uncovered the previously unknown ability of marine microbes to degrade nanoplastics, indicating that microbes play a crucial role in determining the fate of these particles in the ocean. However, marine microbes and the ecosystem services they support could also be negatively impacted by nanoplastics. Building on my team’s innovative approaches, we will conduct in situ experiments across surface and deep sea environments, complemented by investigations under laboratory conditions. Through the NanoMare project, we will be the first to provide fundamentally new insights into nanoplastic degradation kinetics, nanoplastic-degrading microbes (including degradation pathways and genes), impacts of nanoplastics on the ocean’s microbiome, and the global prevalence and distribution of nanoplastics and their degradation products in the sea. The NanoMare project will profoundly enhance our understanding of ocean microbe-nanoplastic interactions and nanoplastic inventories, with substantial implications for marine microbiology and other ocean science disciplines. Beyond the ocean, the results will also be important for the fields of hydrology and atmospheric physics.

Keywords: nanoplastic,plastic degradation bioremediation,stable isotope labeling,stable isotope probing,pollution
Elucidating the cellular basis of therapeutic resistance in Crohn's disease (CD-ResOMics)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: ERA Fellowships (HORIZON-WIDERA-2023-TALENTS-02, 2023)
Start date: 2024-06-16
End date: 2026-06-15
Duration (months): 24.0
Total project cost (EUR): 172618.56
EU funding (EUR): 172618.56
Participants: 2
Project status: SIGNED

Crohn´s Disease (CD) is a chronic inflammatory disease that affects the gastrointestinal tract, affecting millions of people worldwide and presenting a considerable economic burden to health systems. CD has a serious impact in quality of life, not just physically, but also emotionally and socially. Pathogenesis results from a complex interaction between environmental factors, microbiome, genome, and inflammatory system, leading to disruption of the intestinal mucosa. The imbalance between inflammatory and regulatory cells in maintaining an active disease is well known, and most therapies aim to stop the cascade of inflammatory and pro-inflammatory cytokines (i.e. TNF-blockade). One of the major challenges for treatment is the fact that not all patients respond to therapy. Moreover, the mechanisms behind resistance are still not completely understood, making it hard to correctly stratify patients as responders and non-responders at time of diagnosis. We aim to elucidate changes in immune regulation that explain primary response failure to TNF-blockade in CD. We hypothesise that dysfunction of regulatory cells may prevent reinstatement of homeostasis following inflammation targeting. We will establish single-cell transcriptomics of immune cells from biopsies at the time of diagnosis, as well as in patients responding to treatment and non-responders. Then, we will use computational methods to investigate how immune cells change with time, acquiring a state supporting therapeutic resistance. Moreover, we will illuminate the relationship between immune dysregulation and anatomic niches using spatial transcriptomics. Finally, we will analyse paired peripheral blood samples, for the identification of putative biomarkers for stratification of patients according to TNF-blockade response. This proposal will provide unprecedented insights on the mechanisms involved in therapeutic resistance in CD, which could potentially lead to the development of new treatment approaches.

Keywords: crohn s disease single cell transcriptomics spatial transcriptomics therapeutic resistance immune regulation
A novel Renewable Energy Storage System tailored for Offshore Applications (FLASC HPES)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Challenge: Energy storage (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 3571416.25
EU funding (EUR): 2499991.38
Participants: 1
Project status: SIGNED

By 2050, 12% of world primary energy supply will come from wind, of which 20% will come from offshore wind (source: DNV‘s Energy Transition Outlook). This poses a significant challenge to the electricity supply due to wind’s intermittent and unpredictable nature. Thus, energy storage is a decisive factor in exploiting the full potential of offshore wind power. By providing a tailored technology for the offshore wind energy market, we are addressing two of the biggest challenges in the energy industry: 1) the temporal mismatch and 2) the spatial mismatch. FLASC HPES will enable the integration of large-scale energy storage into offshore renewables, catalysing the development of this nascent market. FLASC addresses client-specific Pain Points, bridging the gap for offshore wind developers who are currently exposed to wind intermittency, demand fluctuations, grid congestion and market volatility. A FLASC energy storage system within the windfarm introduces flexibility to the energy supply, increasing profitability which will enable a scale-up in new offshore windfarm deployments. FLASC HPES is a unique energy storage system tailored for offshore that combines two innovations: 1) pneumatic pre-charging, which avoids reliance on hydrostatic pressure; 2)using the ocean as a natural heat sink. The system can be installed in shallow water (~40-400m) and it is suitable for fixed-bottom and floating applications. FLASC is unique when compared to other offshore energy storage concepts because it is compact and less expensive, has a lower environmental impact, and can be co-located in shallower waters within the footprint of the windfarm. With the REPowerEU Plan (the European Commission’s plan to make Europe independent from Russian fossil fuels) aiming at 60GW of installed capacity of offshore wind energy by 2030, FLASC will play a key role in meeting the energy targets while reducing dependence on fossil fuels and gas imports.

Keywords: offshore wind energy energy storage hydrogen renewable energy cleantech energy management smart grid wind power
Codasip CHERI technology (CHERI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 1.0
EU funding (EUR): 1.0
Participants: 1
Project status: SIGNED

The semiconductor industry has long grappled with the inadequacy of security measures in connected products, owing to a fragmented approach to chip design that hinders the implementation of comprehensive security solutions. With cyber threats becoming increasingly sophisticated and the attack surface of computing systems expanding, there's a growing concern over the security of chips, which traditionally prioritized performance and efficiency over security features, leaving them vulnerable to cyber attacks. In 2023, global cybercrime incurred a staggering EUR 10 trillion impact, with 2,220 daily cyberattacks, highlighting the urgency for robust security measures. Recognizing that a software-only solution is insufficient, security must be ingrained in the hardware itself, down to the smallest components: the chips. While conventional approaches offer limited protection with coarse-grained statistical methods and resource-intensive strategies, existing hardware mechanisms fall short in addressing the evolving threat landscape. In contrast, Codasip's CHERI technology, proposed for EIC equity-only funding, offers a deterministic and efficient solution. Thanks to Codasip’s ability to quickly and efficiently customize processors, we are the first to make CHERI available in RISC-V processor cores. CHERI extends conventional ISAs to provide fine-grained memory protection and highly scalable software compartmentalization. Each memory access undergoes stringent checks for access rights, preventing common attacks like buffer overflows. With CHERI, existing software can safely migrate, maintaining backward compatibility while enhancing security incrementally. CHERI does not only address known memory-safety vulnerabilities, but its deterministic hardware control also prevents future memory attacks, making it a crucial preventive security technology.

Keywords: semiconductor,risc v,chip act,cybersecurity,hardware design,hardware engineering,safety and security
Worlwide HYdrological Large-scale Database (WHYLD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-06-01
End date: 2025-06-30
Duration (months): 25.0
Total project cost (EUR): 3672543.75
EU funding (EUR): 2499999.99
Participants: 1
Project status: CLOSED

vorteX.io offers an innovative and intelligent service for monitoring hydrological surfaces, using in-situ remote sensing instruments, based on compact light-weight altimeter inspired from satellite technology: the micro-stations©. It provides in real time, with a high frequency and accuracy, hydro-meteorological parameters (water surface height, water surface velocity, images & videos) of the observed watercourses. The combination of these in-situ data with satellite measurements is thus optimal for downstream services related to water resources management and assessment of flood/drought risks. Thanks to the development of the innovative micro-station© and the onboard processing using artificial intelligence algorithms, the WHYLD project will provide an anytime/anywhere real time hydro-meteorological database to prevent communities from flood risks and secure goods anywhere at any time. The project thus aims to cover the whole Europe through a non-binding turnkey service.

Keywords: very large data bases archiving,handling and analysis,machine learning,statistical data processing and applications using signal processing,artificial intelligence,intelligent systems,multi agent systems,climatology and climate change,remote sensing,service innovation,business model innovation,space data exploitation,open innovation,engineering and technology,corporate social responsibility,micro system engineering,earth observation services and applications,internet services and applications,digital services,water,networks,numerical analysis,simulation,optimisation,modelling tools,data mining,web and information systems,database systems,information retrieval and digital libraries,data fusion,innovation systems,open data,crisis management,artificial intelligence and decision support data mining,risk management,optical sensors,surveillance,earth observation services and applications,gnss services and applications,on board data systems,optics