Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SOURCE APPORTIONMENT OF CLIMATE-FORCING BLACK CARBON IN ARCTIC AEROSOLS BY COMPOUND-SPECIFIC RADIOCARBON ANALYSIS (ARCTIC BC14)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-05-14
End date: 2014-05-13
Duration (months): 24.0
Total project cost (EUR): 181418.4
EU funding (EUR): 181418.4
Participants: 1
Project status: CLOSED

Anthropogenic climate warming is particularly enhanced in the Arctic. The climate forcing agents are CO2, tropospheric ozone, methane, halocarbons and carbonaceous aerosols. A key component is airborne black carbon (BC), which is a highly condensed carbonaceous aerosol released from incomplete combustion of organic matter. Arctic acts as a repository of BC after long-range transport from other emission source areas. Arctic climate is more vulnerable to BC than other regions because of its impact on the albedo of snow, glaciers and sea-ice; accelerating melting and increasing sensitivity to warming. Knowledge about BC sources is a prerequisite for an effective mitigation of the Arctic climate warming but unfortunately the relative contribution of different combustion sources of BC transported to the Arctic is still poorly understood. This project is intended to assist society in targeting efficient mitigation of Arctic climate warming through a reduction of BC emissions. Knowledge about BC sources is a prerequisite for an effective mitigation. In the present research project the sources of Arctic BC will be apportioned with the dual-isotope (13C+14C) approach applied to one key location in western Arctic (Zeppelin mountain, Svalbard) and one in the little studied yet vast Eastern Arctic (Tiksi, Yakutia). Natural abundance radiocarbon analysis allows quantitative apportionment between fossil fuel vs biogenic and biomass combustion sources and stable carbon isotope is informative of the relative importance of wood and grass e.g. crop residues. A reduction in emissions of BC would lead to a slowdown or at least delay in the global warming and in particular a delaying of the rapid melting in the Arctic.

Keywords: black carbon,arctic,short-lived climate forcers,compound-specific radiocarbon analysis,carbon cycle (climate change),aerosols (climate change),biogeochemistry (climate change)
Towards Experimental Full Field Modal Analysis (TEFFMA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-02-01
End date: 2015-07-31
Duration (months): 24.0
Total project cost (EUR): 242193.4
EU funding (EUR): 242193.4
Participants: 1
Project status: CLOSED

The improvements in the electronics of modern cameras have raised the attention on image based technologies also for the measurement of complex vibration patterns for dynamic analyses in a broad extent beyond Holography. The advent of digital cameras has brought ESPI techniques to a recent success. Besides, the production of hi-speed digital cameras has recently raised DIC technique as another competitive technology in the full field domain; the SLDV,thanks to its ability to scan discrete locations over the surface,can also be considered close to the full field technologies. Present dynamic testing and analysis approaches, based on traditional transducers, do not take full advantage of the growing optical measurements, while full field techniques have proved to be increasingly effective in complex dynamic analysis. This project aims at revisiting the procedures & algorithms in structural dynamics and at exploring the feasibility of new specific approaches for full field measurements. The activity will be deployed on: -Comparison of full field technologies (ESPI,SLDV,DIC) for accurate spatial description in broad frequency ranges; dataset requirements, averaging and signal processing -Use of full field FRFs with traditional approaches in dynamic analysis, NVH & EMA, with commercial & custom codes; evaluation of dynamic strain&stress measurements for fatigue predictions; rotational dofs FRFs; model updating -Feasibility studies & implementation of new space domain based algorithms for Experimental Full Field Modal Analysis to exploit the spatial data redundancy in full field measurements The results expected from this research will have a wide applicability and deep impact to strengthen the path of full field technologies in mechanical engineering and other fields, ranging from aerospace to vehicle technologies, electronic components, advanced material behaviour analysis. The success of the project will be an important step in the scientific maturity for career growth

Keywords: full field vibration measurements,optics,experimental modal analysis,espi,hi-speed dic,signal processing,model updating,dynamic strains,rotational dof,fatigue,full field frf,parallel computing
New strategies for corrosion inhibition coatings for lead and its characterization by in-situ spectroelectrochemical studies (PBCOATINGS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2013-06-01
End date: 2015-05-31
Duration (months): 24.0
Total project cost (EUR): 169800.0
EU funding (EUR): 169800.0
Participants: 1
Project status: CLOSED

Lead is susceptible to corrosion in the presence of organic acids and humidity. This accelerated degradation seriously affects cultural heritage objects, it takes place in display cases in museums and is has become a serious issue on organ pipes in churches or concert halls. The pipes of ancient organs are made from lead and the organic acids are emitted from the wooden parts in the organ (the windtrunks and the windchests). The aim of this proposal is the development of environmentally safe corrosion protective coatings for lead heritage objects which are stable, reversible, easy to apply and to remove, and aesthetically justified. Monocarboxylate coatings have shown very promising results, but the effectiveness is highly dependent on carbon chain length, and carboxylate concentration in the solution: higher chain length and concentration, the better the corrosion inhibition effect. Unfortunately, the solubility of monocarboxylates drastically decreases with chain length. The project aims to tackle the key issue of the low solubility of monocarboxylates. As opposed to the strategy of using cyclic voltammetry for coating formation (only applicable to small objects), our idea is to test new coatings easily applicable on site to heritage objects of all sizes, for instance organ pipes. Ideas to be tested include solubilization of monocarboxylates in ethanol and propanol solutions; dispersion of monocarboxylic acids in microemulsions together with surfactant and co-surfactant; embedding this microemulsions in polymeric networks (gels); test of hydroxide nanoparticles as alternative coatings; and the combination of hydroxide nanoparticles and microemulsions as combined optimum coatings. The coating formation and its corrosion resistance will be fully characterized by several surface analyses techniques in the host lab, including electrochemistry, complemented by synchrotron spectroelectrochemical studies.

Keywords: electrochemistry,surface chemistry,corrosion inhibition,conservation of cultural heritage,synchrotron studies
Formation and roles of the 5',8-cyclo-2'-deoxyguanosine lesion (CYCLOGUO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-04-01
End date: 2014-03-31
Duration (months): 24.0
Total project cost (EUR): 185763.6
EU funding (EUR): 185763.6
Participants: 1
Project status: CLOSED

Free radical attack to genetic material leads to damages that are involved in pathologies as well as in aging. Guanine is the preferred oxidation site of DNA, and 8-oxo-dG is used as marker of radical stress, with some drawbacks due to oxidative artefacts during the analysis. The project addresses the chemical biology of 5’,8-cyclo-2’-deoxyguanosine (5’,8-cyclo-dG), a tandem damage produced by free radical insult to the 5’ position of the sugar. The compound has an extra covalent bond between the base and sugar moieties and occurs as 5’S and 5’R diastereomers. Chemical studies on 5’,8-cyclo-dG, paralleled with 8-oxo-dG, are expected to contribute to a full scenario of guanine damage. The project addresses: i) Structure and reactivity features of the 5’,8-cyclo-dG formation and diastereomeric ratios as reporter of different DNA supramolecular organization and environmental factors; ii) chemical and stereochemical issues in different oligosequences and DNA-mimics, including convenient syntheses of various (5’S)- and (5’R)-5’,8-cyclo-dG structures, which represent the limiting step for comprehensive biological and medical research; iii) the 5’,8-cyclo-dG damage in guanine-rich regions such as telomeres, “CpG islands” and introns, intensively studied for cancer and aging processes; iv) aspects of the structural distortion of guanine-rich regions due to the lesion; v) differences in enzymatic recognition and hydrolysis of sequences containing the lesion in the two diastereomeric forms. Main milestones of the project are envisaged: easy access to cyclonucleoside-containing substrates; protocols for characterization of the 5’,8-cyclo-dG lesions and application to damage evaluation in biological samples; assessment of damage in different dietary conditions and cell environments, such as nuclear and mitochondrial DNA; balanced aspects of the damage and repair processes of the 5’,8-cyclo-dG lesion; integration of the 5’,8-cyclo-dG lesion in the whole scenario of DNA damage.

Keywords: organic chemistry,chemical biology,radiation chemistry,dna damage,free radical stress,guanine,modified nucleosides,cyclopurines,oligonucleotides synthesis,g-quadruplex,reaction mechanisms.
The structure-based design of a blocker of formation of amyloid fibers of the segment AADTWE in the mutant D38A of the protein transthyretin, which causes familial amyloidosis. (FIBRILLATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2012-06-01
End date: 2015-05-31
Duration (months): 36.0
Total project cost (EUR): 275362.5
EU funding (EUR): 275362.5
Participants: 1
Project status: CLOSED

Several neurodegenerative and systemic amyloid diseases are putatively caused by the formation of insoluble protein fibrils, which accumulate in human tissues and interfere with normal organ function. The amylome is the set of proteins that are capable of forming amyloid-like fibrils, as consequence of the self-aggregation of some segments. The familial amyloidosis or FAP is a slowly progressive condition characterized by the buildup of abnormal deposits of transthyretin (TTR) in the body's organs. Most patients with FAP have early and severe impairment of the autonomious nervous system and also visual deterioration. A variant of TTR, presenting the D38A mutation, was detected in patients suffering from amyloidosis. Analysis performed by Eisenberg's team showed that the aspartic acid 38 is likely to be within a non self-aggregating segment in the native protein (ADDTWE). However, when this segment carries the mutation (AADTWE), it turns into a self-associating segment (not published). We hypothesize that this segment is the cause of the fibrillation of transthyretin for the D38A mutation and that disrupting packing of the fibril spine can hinder fibrillation. The goal of this proposal is the structure-based design of a blocker of aggregation of amyloid fibers of the segment AADTWE in the mutant TTR[D38A]. We will develop two different strategies for designing putative blockers of the aggregation of TTR: the structure-based design of an all D-peptide inhibitor and the construct of a chimeric protein between aggregation-inhibitor HET-S globular domain and the self-aggregating segment AADTWE. We will have to check the established inhibition model by X-ray crystallography and NMR techniques. Finally, inhibitors can be purchased commercially for synthesis of the designed fibril blockers. This project can be considered as a key in biomedical improvement, especially in neurodegenerative diseases, because it could bring us a way to stop the development of these illnesses.

Keywords: biotechnology,biochemistry,applied biology,computational biology,molecular design,de novo design,physical sciences,nuclear chemistry,structural chemistry
PERPETUATING CAMEROON ANGLOPHONE LITERATURE: A CRITICAL READING OF SELECTED WORKS (CAMLIT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-09-01
End date: 2015-01-17
Duration (months): 24.0
Total project cost (EUR): 231547.2
EU funding (EUR): 231547.2
Participants: 1
Project status: CLOSED

The fundamental objective of this project is to critically assess some selected works of the immense corpus of Cameroon Anglophone Literature to ascertain its place not only in Cameroon and Africa, but in the European literary community. It seeks to examine critically the multivariate sociocultural, economic, political, ideological and linguistic issues of the different genres (drama, poetry and prose) that constitute Cameroon Anglophone Literature as distinctive from Cameroon Literature of English Expression. It also aims at showing that this literature has international standards and contributes to trans-cultural, social and political awareness. Based on interdisciplinary and multiple theoretical perspectives, it will use new historicist, postcolonial, psychoanalytical, feminist and philosophical discourse as interpretative paradigms. In this regard, it will wrestle with the Anglophoneness of the literature as linguistic or ideological, cultural perpetuity with regard to reasserting cultural identity and negotiating new spaces with Western encounters and globalization, gender deconstruction, national awareness and nation building and existentialist questions pertaining to the enigmas and complexities of human existence and experience. The objectives will be achieved through lectures and seminars with the participation of a research team at Munich University whose library has an updated corpus of the said literature. The outcome will be scholarly publications of essays, conference proceedings, and a monograph which can serve as a standard textbook Cameroon Anglophone Literature. Given that no systematic and standardised work has been carried out on this literature, this project will serve as a breakthrough and springboard to a mutually enriching academic exchange. It will provide an opening of new horizons not only to the researcher, but the host university and the international community with regard to academic and intellectual expansionism.

Keywords: cameroon anglophone literature,postcolonialism,literary historicity,gender,cultural perpetuity,existentialsm
Systems Networks Norms (SYSNORM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands,Netherlands
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2013-01-01
End date: 2015-12-31
Duration (months): 36.0
Total project cost (EUR): 354111.7
EU funding (EUR): 354111.7
Participants: 3
Project status: CLOSED

Genomic sciences are driving progress in biology at an unprecedented pace, most recently through third-generation sequencing and synthetic biology. These achievements challenge commonly accepted biological concepts and assumptions in the humanities. In this Fellowship I will investigate the impact of genomic sciences on theory development in the social and human sciences, with focus on philosophy and ethics, and develop innovative normative models that align with this new knowledge. Harvard University will provide a unique setting for this investigation through its juxtaposition of front line genomics and medical research with rich humanities resources. My hypothesis is that systems approaches in biology are replacing traditional ontologies of health and disease - based on compendia of symptoms and test reference ranges - with emergent states and activity levels of nonlinear genetic networks. These concepts will induce substantial changes in objectives of basic research, translation of this research into practice, and, ultimately, the delivery and prioritization of health services. This shift must be assimilated into the philosophy and ethics that appraise these activities. Research and training at the Church lab at Harvard Medical School, a Center of Excellence in Genomic Science, will propel my academic career and bring innovative knowledge to Europe. The plan will be to work hands-on with genomic scientists to identify and develop specific examples of pathway characterizations that are in the process of replacing current health and disease categories, extrapolate how these foundational changes will translate into basic research and health care practices, and use the network examples to develop a blueprint for a systems biology-relevant normative model. Specific training objectives are framed in the proposal for human systems biology, network theory and analysis tools, medical genetics and ethics, and in the practice of professional scientific leadership.

Keywords: philosophy,ethics,normative theory,philosophy of science,biology,biological sciences,genomics,systems biology,synthetic biology,network theory,human health,disease ontology,translational research
The evolution of gene content in parasitic protozoa (EVOGCPROTO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-04-01
End date: 2014-03-31
Duration (months): 24.0
Total project cost (EUR): 200371.8
EU funding (EUR): 200371.8
Participants: 1
Project status: CLOSED

Protozoan parasites from diverse evolutionary lineages including Trypanosoma and Leishmania, Giardia, Entamoeba, Plasmodium and the microsporidia have a major impact on human health, especially in developing countries and among immunocompromised individuals. During their evolution as parasites these organisms can both lose pathways if they can steal host metabolites and gain genes that may help them to manipulate their hosts. It is this balance of genome reduction and genome expansion, and the potential consequences for parasites and their eukaryotic hosts, that I will investigate in my project. Although the genome evolution of bacterial pathogens is relatively well studied, much less is known about how eukaryotic parasites - which are much more similar to their hosts - evolve at the genomic level. A sophisticated analytical approach will be used to compare genome reduction and expansion events in different groups of parasitic eukaryotes and their free-living relatives, to identify lineage specific and common evolutionary features. This framework will be used to identify and characterize new, parasite-specific protein families that may be involved in pathogenesis and, as an important part of my training, I will collaborate with bench scientists in the host lab to test these hypotheses. By identifying the gene families that are gained and lost during the evolution of parasitic protozoa, I will identify cases when bacteria and eukaryotes evolve in similar and different ways and hence gain insight into how parasites evolve more generally. Moreover, since parasites may lose genes that are strongly conserved among free-living model organisms, they also represent “natural experiments” for understanding which features of eukaryotic cells are essential and which are lineage specific elaborations. As a test case to explore this principle I will investigate the evolution and conservation of proteins involved in a fundamentally important eukaryotic pathway - the cell cycle.

Keywords: natural sciences,evolutionary biology,phylogeny,computational biology,protozoology
Quantum Information Theory with Liouvillians (QUINTYL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-10-01
End date: 2014-09-30
Duration (months): 24.0
Total project cost (EUR): 167390.4
EU funding (EUR): 167390.4
Participants: 1
Project status: CLOSED

The project's main goal is composed of a scientific and an academic training component, and it is to be implemented in the Department of Mathematics at the Technical University of Munich in the research group of Prof. Michael Wolf. The first scientific aim is to extend the mathematical framework underlying the ''dissipative paradigm'' of quantum computing, placing special emphasis on continuous-time evolutions that may be controllable to a certain extent and may include non-Markovian elements. Providing such a rigorous toolbox and extending vital theorems from the Hamiltonian case to the dissipative paradigm forms the first two scientific objectives. Two further objectives use these tools to achieve the project's aim to incorporate controllable dissipative evolution into central parts of Quantum Information Theory. Namely, we aim to establish a Quantum-Shannon-Theory for the controllable time-continuous case - relevant for quantum memories - and explore its basic features. Further, we aim to investigate the computational complexity of dissipative state preparation in quantum many-body systems, contrasting it to Hamiltonian Complexity. These objectives will be achieved mainly through analytic work, also employing computer simulations. Beyond research, the academic training component aims to prepare the fellow for a future career as an independent researcher. As specific objectives to achieve this, the fellow will mentor students and (co-)supervise research projects jointly with Prof. Wolf during the fellowship. Further, the fellow will (co-)teach a specialized lecture course and a seminar. Through active involvment in the research group and grants, the fellow aims to acquire essential leadership and management skills. The project objectives are of high relevance to the Work Programme PEOPLE since they strengthen the human potential in research in Europe by supporting the fellow in attaining a leading independent position as professor at a European university.

Keywords: quantum information theory,quantum markovian master equations,mathematical physics,dissipative quantum computing,quantum shannon theory,hamiltonian complexity