Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hydropower infrastructure in Andean headwaters: Combining Observations and Remote sensing to analyse Environmental impacts (HydroCORE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium,Ecuador
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-07-01
End date: 2026-06-30
Duration (months): 36.0
Total project cost (EUR): 238764.48
EU funding (EUR): 238764.48
Participants: 2
Project status: SIGNED

Hydroelectric power is a popular alternative to burning fossil fuels, especially within the Amazon river basin. However, no single hydropower installation is without any environmental impact. By damming a river, significant alterations do occur in the hydrological connectivity, which reverberate in the river’s morphological state and physicochemical conditions. Moreover, consequent changes in the structure and functioning of the aquatic community have a tendency to negatively affect various ecosystem services, thereby putting local societies at risk and undermining the goal of sustainable development. Various qualitative global assessments have certainly helped illustrating opportunities and threats, but have failed to be compatible with local management needs and ecological perspectives. Therefore, the aim of this research is to monitor, analyse, evaluate and illustrate the impacts of reservoir-based hydropower infrastructure on the morphology, hydrology and quality of Andean headwaters within the Amazon river basin by combining (i) remote sensing, (ii) process-based hydrological modelling and (iii) water quality assessment based on field campaigns with a high temporal resolution. Additional focus is directed at the interaction with climate change, including the contribution through emissions of greenhouse gases (field measurements) and the challenges under future climate conditions (modelling). To do so, the Paute river basin (Ecuador) is selected as study area to (i) overcome the local data scarcity, (ii) develop a protocol for evaluating similar systems and (iii) preserve the uniqueness of these headwater ecosystems. Project activities and obtained results will be publicly accessible and continuously disseminated online and in-person. As such, this research will increase local and global understanding of and reduce the environmental impacts associated with reservoir-based hydropower installations.

Keywords: hydropower,impact,freshwater,remote sensing,hydrology
INTERCONNECTING 4 HELIX INNOVATION ECOSYSTEMS IN EUROPEAN REGIONS (INTEGER)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Spain,Ireland,Germany,Poland,Portugal,Netherlands
Call: Integration of social innovation actors in innovation ecosystems (HORIZON-EIE-2022-CONNECT-01, 2022)
Start date: 2023-02-01
End date: 2025-01-31
Duration (months): 24.0
Total project cost (EUR): 566078.91
EU funding (EUR): 499920.45
Participants: 9
Project status: CLOSED

Focused on challenge-driven promotion of healthy living, INTEGER will bring forward three important innovations for the development of more robust, sustainable, inclusive and integrative EU innovation ecosystems: 1.The INTEGER 4 Helix Collaboratory model to implement the next generation of living labs, the ‘Collaboratories’, 2.A EU Healthy Living Collaboratory, a true network of networks’ community with capacity to work on real social, tech and business-driven projects, and 3. A new professional profile, the ‘collaber’ or ‘collaboratory manager’ as a multiplying agent of change of these integrated innovation ecosystems. The 3 INTEGER reinforcing innovations will push fivefold breakthrough capacities for the integration of social innovation in EU innovation ecosystems: 1)Boost win-win games between business and social oriented innovations addressing common challenges. 2)Transform co-creation dynamics into disruptive and tangible new products, services or competencies. 3)Co-design jointly public innovation policies. 4)Develop capacity building of the new generation of socio-digital entrepreneurs and ecosystems’ enablers, the collabers, and 5)Devise funding and investment mechanisms for social innovation start-ups and SMEs to develop and scale up game changing innovations. Collaboratories and collabers aim to embrace economic and social-driven innovation communities across EU. As novel 3H and 4H social-business innovation integration structures, these “labs without walls”, are becoming the common open house of all kinds of innovators and entrepreneurs interested in producing new products and services that come from business or social oriented innovation. Based on a peer-to-peer approach between business-driven and social-driven innovations, INTEGER seeks to accelerate transformative integration outcomes by creating new win-win games, local mission-driven synergies, groundbreaking coordination of actions, governance, implementation, uptaking and exploitation dynamics.

Keywords: challenge driven,citizenship,quadriple helix,governance,collaboratories,healthy living,multi stakeholder collaboration
Monocytes loaded with magneto-opto-acoustic nanodevices, as Trojan Horse cancer theranostic agents (MOAN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-12-01
End date: 2027-11-30
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 3
Project status: SIGNED

Nanoparticles are gaining increased biomedical relevance in cancer applications due to their theranostic capacity by integrating in a single entity imaging contrast in different biomedical techniques and local therapeutic action. However, current theranostic nanostructures suffer from limited contrast intensity, reduced imaging and therapy depth, and poor circulation time and penetration into solid tumors. To overcome such limitations, novel magneto-opto-acoustic nanodevices (MOANs) loaded into monocytes, as Trojan Horses, are proposed in this project. The MOANs will be composed of mechanically resonant micro/nano-plates with resonance in the ultrasound biomedical window (1-10 MHz), merging magnetostrictive and photothermal bimetallic properties. As a result, alternating magnetic fields and intensity modulated near infrared light beams at the resonant frequency will turn MOANs into amplified ultrasound sources, as new contrast agents. Moreover, their magnetic/optical properties will combine photothermal and magneto-mechanical therapies. The MOANs loaded monocytes will enable the following in progress in Theranostics: i) enhanced circulation time and penetration in solid tumors given by the innate properties of monocytes, ii) amplified ultrasound contrast in superficial and deep tissues with lower intensity magnetic field or light intensity, and iii) efficient magneto-mechanical and photothermal local therapy inside tumors. To demonstrate the biomedical potential in vitro and in vitro, a new MOA scanning microscope and a compact MOA device will be developed. This project will allow me to deepen my multidisciplinary expertise in areas such as microfabrication, magneto/opto-mechanical effects, or in vitro and in vivo assays. Leveraging my existing experience in optical and magneto-optic device development and biofunctionalization techniques, the MOAN project will enable me achieving the scientific maturity necessary to pursue an independent research career.

Keywords: magneto acoustic,opto acoustic,contrast agents,photothermal,magneto mechanical,nanotherapies,immune cells,monocytes
Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV (STOOL4TB)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Spain,Mozambique,Uganda,Eswatini,Netherlands,Germany
Call: Funding to successfully finalise EDCTP2-funded clinical trials that were negatively impacted by the COVID-19 pandemic (HORIZON-JU-GH-EDCTP3-2023-01, 2023)
Start date: 2025-01-01
End date: 2025-12-31
Duration (months): 12.0
Total project cost (EUR): 348247.5
EU funding (EUR): 348247.5
Participants: 6
Project status: SIGNED

The COVID-19 pandemic had a devastating impact on tuberculosis (TB) control. In 2020, the number of people newly diagnosed with TB decreased by 18% despite a rising global TB burden. Intensified efforts to improve TB case detection are critically needed, especially in populations in whom bacteriological confirmation is suboptimal, such as children and people living with HIV (PLHIV) who have also been disproportionately affected by the pandemic. The need for highly sensitive sputum-free diagnostic tools for TB has never been greater. STool4TB, an EDCTP-2 funded diagnostic trial, began its activities in 2020 shortly after the onset of the COVID-19 pandemic. The study aims to validate a novel quantitative PCR assay utilizing a stool homogenization and DNA isolation method that yields a highly sensitive and specific detection of Mycobacterium tuberculosis. STool4TB is implemented in high TB & HIV burden settings of Mozambique, Eswatini, and Uganda under the hypothesis that it will contribute to narrow the large TB case detection gap by improving TB lab-confirmation rates in children and PLHIV, while proving feasible and acceptable. New evidence suggests that this platform has a higher sensitivity when compared to sputum culture and Xpert Ultra and could have an additive lab-confirmation yield of up to 20%. STool4TB is also evaluating the qPCR platform as a treatment monitoring tool. This assay has the potential to be adapted to a POC diagnostic test which could be easily implemented in decentralized levels of care. Given the impact of the COVID-19 pandemic on TB notifications at the three participating sites and on several STool4TB core activities, we request additional funding to finalize recruitment of participants and achieve the target sample size, ensuring full execution of all project’s objectives. The observed upward trend in global TB burden makes the development of promising diagnostic tools, such as this novel stool-based qPCR, more important than ever.

Keywords: tuberculosis,hiv,paediatric,paediatric tuberculosis,stool,stool diagnosis,tb diagnosis,diagnostic trial,stool based diagnosis,novel diagnostic assay
Appraising the Critical Role of prognostic Biomarkers in the Assessment and Triage of sick African newborns: Advancing a point-of-care device based on sTREM-1 towards CE marking and implementation (ACROBAT Newborns)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Spain,Mozambique,Uganda,Ethiopia,Gabon,Nigeria,Germany,United Kingdom
Call: Advancing point-of-care diagnostics to the market (HORIZON-JU-GH-EDCTP3-2023-02-two-stage, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 4808065.0
EU funding (EUR): 4808065.0
Participants: 10
Project status: SIGNED

The main concern of clinicians when addressing sick patients is to promptly identify -i.e., “not miss”- those at higher risk of severe disease, so as to prioritize their care and better target therapeutic interventions. Unfortunately, risk-stratification practices for infections remain suboptimal and prone to misclassification, leading to adverse outcomes and misallocation of resources, particularly in children (and even more so among newborns) from Sub-Saharan Africa (SSA). We recently developed “B-Triage”, a point-of-care rapid triaging test, designed for the quantitative assessment of sTREM-1, a biomarker of sepsis, and a highly performing prognostic marker, irrespective of underlying disease. Levels of sTREM-1 stand out as a quantitative and independent predictor of severity and death in all-cause infections, being superior to other markers and clinical scores, showing promise also for risk-stratification of non-communicable diseases. We propose to specifically validate B-Triage for risk-stratification of all cause sickness in the newborn, the age group concentrating ~50% of all child mortality. ACROBAT-newborns aims to continue and accelerate the valorisation of our device, with clinical studies in Mozambique, Ethiopia, Uganda and Gabon; the industrialization of its prototype; and a go-to market strategy for SSA. The project includes strong components of health economics and impact assessment, as well as socio-behavioural sciences (usability, acceptability, and feasibility studies), with the overarching aim of generating the necessary evidence to support B-Triage’s introduction to the African market. The proactive use of our device for risk-stratification of the sick newborn at first clinical presentation, will determine, objectively and with high precision, those at risk of severe outcome and death, resulting in improved outcomes and survival, and an optimized use of healthcare resources, including antibiotics and high value therapeutics.

Keywords: neonate prognostics risk stratification triage point of care severity
Education for Standardisation in the EU (Edu4Standards.EU)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Coordination and support actions
Countries involved: Germany,Lithuania,Netherlands,Italy,Sweden,Belgium,Austria,Norway,Serbia,Spain,Ireland
Call: Provide for a strong and sustainable pool of experts for European Standardisation: attract the students of university/HEI (HORIZON-CL4-2023-HUMAN-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 3161632.23
EU funding (EUR): 2994601.72
Participants: 18
Project status: SIGNED

Standards significantly impact EU’s GDP, its competitiveness in global markets, but also the promotion of the Single Market and are key instruments for disseminating its core values and supporting its New Industrial Strategy and Green Deal. Likewise, they are essential for efficiently developing the digital, data-driven and, and green economy, and supporting the EU’s interests in global markets and are perceived as important future tools for disseminating its core values. Nevertheless, EU stakeholders do not fully exploit the opportunities of standardisation. The number of the EU’s standardisation experts is insufficient, in particular in international committees; a pool of young professionals from the EU entering standardisation are missing is needed. Standardisation education can address these challenges, but is underdeveloped and fragmented at all EU education levels. Edu4Standards.eu addresses this by specifying standardization skills needed in the EU, analyzing the fragmented teaching landscape and its gaps, and developing an Innovative Teaching Concept on Standardardisation (ITCoS) suitable for various study contexts and specifically considering digital, green, and social aspects. Edu4Standards.eu involves all levels from BSc to professional education and all key stakeholders, represented by 11 HEIs from 9 countries, CEN incl. 27 national NSBs, 1 RTO, 3 SMEs, and extensive stakeholder networks with >300 organisations and an External Advisory Group with all international standardization bodies and industry representatives. Main outputs: ITCoS, 5 pilots with robust and efficient direct and distant standards teaching modules, 15 EU Academic Standardisation Days, a Students’ Standardisation Association, a CEN Workshop Agreement and a EU Roadmap for Standardisation on Education. On this basis, Edu4Standards.eu aims to facilitate standards education in more than 100 HEI (Bsc. and Msc. courses) and contribute to additional 5,000 standards experts p. a. by 2027.

Keywords: standardisation,standards,hei,education
Religion and Conversion in Late Imperial China (REACCH23)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Singapore,Japan
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-01
End date: 2027-06-30
Duration (months): 36.0
Total project cost (EUR): 292043.52
EU funding (EUR): 292043.52
Participants: 3
Project status: SIGNED

This research project focuses on REligion And Conversion in China (REACCH). It constitutes an interdisciplinary endeavour aiming at surveying and analysing how people who lived in late imperial China (roughly between the 14th to the 19th century) discussed, conceptualised and described phenomena that can be heuristically categorised as “conversion”. The ultimate goal is to develop a comprehensive theory of conversion that transcends the Western origins of the concept and can account for the unique features of the Chinese context:to achieve this purpose, the research will primarily focus on case studies related with Confucianism, Buddhism and Daoism. The research will investigate the narratives of conversion that characterised the religious landscape of late imperial China and ascertain if and how the concept of conversion was addressed in the sources of the Ming and Qing dynasties. These sources will include official documents (edicts, memorials, codes of law, legal records), gazetteers (dedicated to towns, prefectures, provinces, mountains, temples and monasteries – in particular, biographical sections of Confucians, Daoists and Buddhists), Daoist and Buddhist texts, works by Confucian literati, epigraphy and “precious scrolls” 寶卷. The theoretical framework of this research project will be drawn from existing scholarship on late imperial China and Chinese religions, as well as from the fields of Sociology of Religion, Psychology of Religion and Religious Studies. The long-term objective is to develop a theoretical framework that will enable comparative studies of religion and conversion across different historical periods and civilisations.

Keywords: conversion in chinese religion,late imperial china,confucianism,buddhism,daoism
Assessing the impact of digital technology solutions in agriculture in real-life conditions (QuantiFarm)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: Greece,Netherlands,Italy,Portugal,Finland,Bulgaria,Belgium,Ireland,Spain,France,Romania,Lithuania,Latvia,Croatia,Slovenia,Serbia,Cyprus,Switzerland,United Kingdom,Poland
Call: Assessing the impacts of digital technologies in agriculture – cost, benefits and potential for sustainability gains (HORIZON-CL6-2021-GOVERNANCE-01, 2021)
Start date: 2022-07-01
End date: 2026-03-31
Duration (months): 45.0
Total project cost (EUR): 7397382.5
EU funding (EUR): 7397382.5
Participants: 35
Project status: SIGNED

The QuantiFarm project focusses on supporting the further deployment of digital technologies in agriculture (DATs) as key enablers for enhancing the sustainability (economic, environmental, social) performance and competitiveness of the agricultural sector. It will achieve this by establishing a framework for assessing the impact and effectiveness of DATs in agriculture and developing innovative tools, services and recommendations for farmers, advisors and policy makers. Following a multi-actor approach, QuantiFarm will build the project activities around 30 Test Cases (TCs) which span over 20 countries in 10 (of the 11) Biogeographical regions across Europe, capturing multiple geo-political and financial settings. All 30 TCs take place in commercial farms of different types, sizes, ownership and operating conditions from 7 agricultural sectors. Different aspects of these TCs will be examined in the context of different work packages (WPs). The TCs’ actors will be engaged in participatory observation activities to offer valuable input and actively support the behavioural analysis (WP1), the establishment of the Assessment Framework (WP2) and the co-design of an innovative Toolkit for farmers, advisors and policy makers (WP3). The lean multi-actor approach will be used in the testing activities to evaluate the QuantiFarm Toolkit and validate the Assessment Framework by testing the various DATs in real life conditions, across 3 iterations/growing seasons (WP4). The outcomes will be transformed into policy recommendations (WP5) and will feed the QuantiFarm DIA that will help build the capacities of farmers’ advisors in DATs. Finally, a WP on dissemination, ecosystem building and exploitation (WP6), will guarantee the wider dissemination and knowledge transfer in a multi-actor context of the outputs of the project. QuantiFarm includes 32 partners, 12 of them representing farmers and advisors.

Keywords: digital agriculture technologies,assessment framework,innovative advisory services,digital tools,sustainability assessment,cost benefit analysis,independent monitoring,cap,decision support
Geodesic currents and geometric structures (CurrGeo)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Luxembourg,France,United Kingdom
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-06-15
End date: 2027-06-14
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 3
Project status: SIGNED

This project will study the intrinsic geometry of the space of geodesic currents of a hyperbolic surface, a suitable closure of the space of weighted closed curves containing many geometric structures. This space has been crucial in many technical developments in the field of hyperbolic geometry, Bers-Teichmueller theory and the geometry of 3-manifolds. Recently, it has permeated into other fields of mathematics, such as compactifications of character varieties or geometric group theory. The goal of the project is to further these applications and unveil new connections with physics, in the setting of conformal field theories.

Keywords: geodesic currents,hyperbolic geometry,teichmueller theory,hyperbolic groups,geometric group theory