Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Prevention of childhood Acute Lymphoblastic Leukemia immunology links oncology (PreventALL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-07-01
End date: 2025-06-30
Duration (months): 60.0
Total project cost (EUR): 1498925.0
EU funding (EUR): 1217925.0
Participants: 2
Project status: SIGNED

PreventALL analyzes genetic risk in infection induced ALL and will pioneer leukemia prevention. Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer and it remains a major cause of death in children aged 2-6 years in high-income countries. Exposure to infection, as a potential trigger for the development of childhood ALL was theorized a century ago with several possibilities of exposure to infection in infancy. Consequently, the overall objectives of PreventALL is to systematically analyze postnatally the genetic risk to develop B-cell-precursor (BCP)-ALL and to decipher the infectious mechanism by which exposure to infection causes BCP-ALL. This opens a new horizon for the understanding of leukemia etiology and foster innovation in the development of novel preventive strategies such as diet supplementation or vaccination. To this end, appropriate methods of postnatal risk calculation and in vivo models are needed. We have recently developed the first in vivo murine models with infection-dependent BCP-ALL, based on a genetic predisposition. PreventALL aims to extend this knowledge and to set off for cutting edge research to explore the synergy of genetic predisposition and exposure to infection in BCP-ALL as a proof-of-concept for the role of infection in precancerous disease. In PreventALL Aim 1 will compile novel strategies to identify patients at risk for BCP-ALL, in Aim 2 I will develop preclinical infection-dependent BCP-ALL in vivo models and identify the mechanism how infection triggers BCP-ALL with respect to the genetic predisposition and finally Aim 3 will set up to develop preclinical prevention programs. In summary, PreventALL will establish a significant milestone in the understanding of childhood leukemia and set the starting point for the development of novel and innovative leukemia precision prevention.

Keywords: prevention,childhood leukemia,vaccination,diet,microbiome,genetic predisposition
Creating Artificial Turf (AT) Yarns with New Recycling Technologies for Circular Economy (CREATE)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: Denmark
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-10-01
End date: 2023-09-30
Duration (months): 36.0
Total project cost (EUR): 3570000.0
EU funding (EUR): 2499000.0
Participants: 1
Project status: SIGNED

Re-Match was founded with the ambition of setting the new global standard in recycling artificial turf (AT), while protecting the environment. We aim to develop a sustainable, transparent, proven solution, promoting a full circular economy based on the upcycling of every AT component. To achieve a complete, cycle of used ATs, Re-Match has developed a ground-breaking patented process combining state-of-the-art technologies, adding the missing link to complete the upcycling of the plastic component. Re-Match is already capable of separating used ATs into sand, rubber and plastic (the first two efficiently recycled). Now, by dissolving the high-quality clean plastic material into a new resin, we will generate new turf yarns of similar quality to the originals, to be applied into new ATs, significantly reducing the waste derived from ATs and decreasing their environmental footprint. The process offers a cradle-to-cradle solution and a fully circular economy model for every AT component. Over 5 years, our resin has the potential to cumulatively save 450,000 tons of CO2e due to recyling of plastic fibres which have traditionally been difficult to be disposed off. As the AT demand and disposal has steadily increased following an annual growth of 16.6% between 2015 and 2017, and the sports segment is the most sought after, Re-Match aims to capture the new trends related to green and sustainable processes. As the team has grown, we have strengthened the process development and initiated the setup manufacturing capabilities, achieving important technological and commercial milestones. This project, aligned with our company strategy, will in a 5-year term allow the expansion of the full business, accumulating profits of €20M and creation of additional 22 FTEs exclusively from the EIC Accelerator project. In the long term, Re-Match will target the delivery of the plastic components also to other applications, establishing a new standard for plastic use and end-purpose.

Keywords: circular economy,artificial turf,recycling,upcycling,process technology
Proposal for innovative and sustainable polyculture greenhouse system Polydome (Polydome)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Estonia,Netherlands
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Polydome is an innovative, sustainable, closed-loop polyculture greenhouse system intended to solve the problem of long distance food sourcing. By polyculture we mean producing approximately fifty different fruit and vegetable crops, two mushroom crops, chickens, fish in amounts capable of feeding between 3,000 to 5,000 people on one hectare. This type of greenhouse will produce no waste and reduce food miles considerably, it will also extend the growing season in harsh climates. The commercial potential of this innovation will be European and global scale as our global population is on the way to 9.1 billion by 2050, only 35 years. To meet the increasing demand, world food production will need to rise by 70%, and food production in the developing world will need to double. Compounding the challenge, we must provide these rising populations the increasingly calorie dense food they will require. The current industry is focused on growing single crops on large tracts of land and then shipping them around the world. The outcome of this project will lay grounds to developing a large scale Polydome, and further more, prove to be productive and profitable in difficult climates. The Feasibility Study will explore the possibility of setting up such a large-scale test site of the concept, which has been developed theoretically and tested partially in the Netherlands, in Estonia. The objective of Phase 1 is to perform a feasibility study consisting of both an on-the-ground pre-assessment and subsequent concept design to build a commercial scale one hectare Polydome, a closed loop, very high yield greenhouse, capable of operating in Estonia year round, that can be applied to both large commercial situations and urban agriculture.The objectives of Phase 2 will to build the Polydome and launch the business operations.

Keywords: sustainable agriculture
Smart Large Scale Radio Technology for the Tactile Internet (SmartRay)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Germany
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-10-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

For future mobile wireless services and applications, network operators must deliver exponentially increasing capacity, carrier grade reliability, and efficiency without increasing CAPEX and OPEX significantly. Airrays has developed game changing radio technology for the 4th and 5th generation mobile communication networks that meets these challenges. By using software-controlled beams, Airrays radio units direct signal energy from a cellular base station to exactly where it is needed, e.g., at individual users or hotspots. Compared to state-of-the-art, the technology provides up to 10-fold increased capacity, 10-fold reduced energy consumption, and 10-fold increased reliability, as well as reduced deployment and operational cost of up to 50%. The objective of the innovation project SmartRay is to commercialize Airrays’ advanced antenna technology and to successfully enter the mobile network infrastructure market. Airrays will position themselves initially as component supplier to established infrastructure vendors and antenna manufacturers and, at a later stage, leverage its technology advantage to become vendor of radio units and deliver directly to network operators. This ambition is in line with current disruptive trends in the 4G and 5G infrastructure market where small vendors establish themselves alongside large established players. Through product development as well as successful commercialization Airrays will explicitly strengthen the European communication infrastructure sector. SmartRay Phase 1 will among others conduct a complete FTO analysis, provide detailed product roadmap, and develop a concrete go-to-market strategy to identify an initial market segment to address.

Keywords: 5g mobile communications
Composite-particle approach to Symmetry Protected Topological Phases (CompositeSPTphases)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The sum being greater than its parts is a common theme in condensed matter physics. Materials made of large numbers of simple constituents often exhibit intriguing and markedly distinct phases of matter with properties very different from any of the individual constituents. Understanding the possible phases of matter and identifying them in real materials is the central focus of this branch of physics. Roughly speaking, two categories of phases of matter exist--- conventional phases which show a geometrical pattern of order, and topological phases, where the order is more elusive and related to topological concepts. In the past three decades, topological phases have attracted a large amount of interest due to their tendency to exhibit highly robust quantum phenomena which has various applications in quantum engineering and metrology. The current frontier in the field aims at understanding the variety of novel topological phases which arise when some extra symmetries, such as time reversal, are not allowed to be broken. In this project we explore this new type of phase using the concept of composite particles --- an idea which has been extremely useful in previous studies of topological matter, but has not been applied in the symmetry-protected context previously. The fundamental idea behind our approach is to view symmetry protected topological (SPT) phases of spin/electron systems as conventional ferromagnets/superconductors/metals of composite objects. Besides its conceptual importance, such an approach will allow us to utilize our knowledge of conventional phases in the context of SPT phases and also derive microscopic models which realize these states of matter. It will thus increase the chance of discovering new SPT phases in nature.

Keywords: topological phases,spts,field theory,quantum computation
Transparent p-type semiconductors for efficient solar energy capture, conversion and storage. (p-TYPE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-01-01
End date: 2023-06-30
Duration (months): 78.0
Total project cost (EUR): 1499840.0
EU funding (EUR): 1499840.0
Participants: 1
Project status: SIGNED

This proposal will develop new transparent p-type semiconductors that will make dye-sensitized solar cells (DSC) a vastly more efficient and a realistic prospect for carbon-free energy generation worldwide. Two key challenges will be addressed: (1) a means of converting NIR radiation to increase the amount of sunlight utilised from 35% to over 70%; (2) a means of storing the energy. Almost all the research in the field is based on dye or “perovskite” sensitized TiO2 (n-type) solar cells, which are limited by their poor spectral response in the red-NIR. pTYPE approaches the problem differently: tandem DSCs will be developed which combine a n-type and a p-type DSC in a single p/n device. This increases the theoretical efficiency from 33% to 43% by extending the spectral response without sacrificing the voltage. The device will be modified with catalysts to convert H2O or CO2 and sunlight into fuel without using sacrificial reagents that limit the efficiency of current systems. An efficient tandem DSC has not yet been developed because p-type DSCs are much less efficient than n-type cells. As an independent Royal Society Dorothy Hodgkin fellow I increased the photocurrent by developing new dyes. This project will exploit this breakthrough by increasing the voltage, which is currently limited by the NiO semiconductor conventionally used. I will rapidly synthesise libraries of alternative p-type semiconductors; select promising candidates based on key criteria which can be measured on a single sample within minutes: transparency and dye adsorption (for high light harvesting efficiency by the dye), conductivity (for high charge collection efficiency) and valence band potential (for high voltage); assemble the new materials in tandem DSCs. As one of the few researchers experienced in preparing, characterising and optimising each aspect of this photoelectrochemical system, I aim to match the efficiency from TiO2 with p-type DSCs to obtain tandem efficiencies above 20%.

Keywords: dye sensitized solar cells,renewable energy,artificial photosynthesis,solar fuel,electrochemistry
Thermo-adjustable endoscope heater system to solve problems of fogging during surgical interventions (EHS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Maintenance of optimal vision during minimally invasive surgery is crucial to maintaining operative awareness, efficiency and safety. Hampered vision is commonly caused by laparoscopic lens fogging (LLF) which has prompted the development of various anti-fogging fluids and warming devices. Numerous tricks have been proposed to overcome this issue, such as heating the scope into a sterile thermos flask filled with hot water, or using one of the commercially available antifogging solutions. However, whether one method is superior to another remains elusive. As most surgeons know, none of these tips are totally efficient, as they don’t treat the cause: the temperature difference. Taking into account this need, Noruco has developed EHS, a thermo-adjustable system by microcontroller, which is implemented in the manufacturing process of the rigid endoscope focused on laparoscopy. The technology enables the selfmodulation of the temperature of the endoscope within the different conditions during the surgery, avoiding the 100% of laparoscopic fogging. With the adoption of EHS surgeons get a clear field of vision avoiding continues repetitions of extraction and insertion of the endoscope in the body during the intervention. In this way the risks of the patients are reduced with a more efficient and shorter duration procedure. EHS also represents an alternative that meets sustainability criteria by reducing energy costs and eliminating much of the waste currently generated by this procedure. Therefore, this innovation will disrupt the laparoscopic device market by enhancing safety and effectiveness without introducing new components that could complicate surgical procedures.

Keywords: laparoscope,anti fogging,endoscope
Next Generation Gene Therapy for the Treatment of Chronic Myocardial Ischemia and Heart Failure (HeartGenes)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Finland
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

BACKGROUND: Therapeutic angiogenesis has great potential for the treatment of severe heart diseases. However, this requires novel approaches and development of new technology. ADVANCING STATE-OF-THE-ART: We will develop novel VEGF-B and VEGF-C-based gene therapy to treat refractory angina and heart failure (HF). VEGF-B and VEGF-C lead factors were selected from extensive pig studies where they showed the best benefits among all VEGFs, such as relative cardiac specificity, potent angiogenic and metabolic effects (VEGF-B) and lymphangiogenic activity (VEGF-C). Exogenous gene transfer and new endogenous gene activation technology will be developed. Key new technologies are riboswitch-regulated-AAV8 vectors, Super-Enhancer driven cell-type targeted gene expression, VEGF-B and VEGF-C designer mutants for better efficacy and activation of natural endogenous VEGF-B and VEGF-C expression with promoter binding shRNAs, circRNAs, CRISPR/mutantCas9-VP64-SAM gene activation technology and using a novel concept of the release of promoter pausing. Immunological concerns of AAV8 and usefulness of new synthetic dendrimer carriers will be addressed. HeartGenes utilizes optimized percutaneous intramyocardial and retrograde venous gene delivery in pig chronic ischemia and HF models, clinically relevant pig exercise test, and 15O-H2O and 18F-FDG PET/MRI imaging to detect treatment effects. Simultaneously, HeartGenes will take a realistic approach to clinical translation and starts intramyocardial vs retrograde venous riboswitch-AAV8-VEGF-B186 phase I trial in refractory angina as the first step to bring the best novel constructs and the most advanced functional and imaging endpoints developed in HeartGenes to clinical testing at the end of the project. SIGNIFICANCE: If successful, this approach will bring a paradigm shift to cardiac gene therapy and new therapeutic options for heart diseases. Novel new technologies may also become widely applicable in other areas of medicine.

Keywords: angiogenesis,cardiovascular diseases,clinical trial,endogenous gene regulation,gene therapy,imaging,ischemia,non coding rnas,promoter pausing,translational studies,vascular endothelial growth factors,vectors
Photonic Integrated Microcombs as Multi-wavelength Sources for Edge Data Centers (PhoMEC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Switzerland
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-11-01
End date: 2021-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Over the past ten years the Laboratory of Photonics and Quantum Measurements (LPQM) has developed and pioneered microcombs – photonic integrated optical frequency combs (OFC), providing access to equidistant optical carriers. Due to their broad bandwidth, high repetition rates, compactness and wafer-scale fabrication, such microcombs represent a novel disruptive technology with a proven track record. While their advantages were shown in ultrafast ranging (LIDAR), high-speed coherent telecommunications, as well as chip-scale atomic clocks and frequency synthesizers, the technology is not yet commercially available and only present in a few research laboratories worldwide. Recent LPQM advances have led to the development of unique proprietary Si3N4 microfabrication processes for ultra-low-power microcombs, and allowed in-house photonic packaging. Taken together the laboratory is now able to implement full-cycle production of a packaged microcomb ready for the integration into a commercial product. We aim to bring the technology to the market by building and promoting a rack-mountable microcomb unit with 100 GHz channel spacing matching the ITU frequency grid over C- and L- telecom bands. The key market segments of the proposed microcomb unit are enterprise and edge data centers, facing growing data traffic and requiring WDM sources for high-speed interconnects. The product will be tested in collaboration with Microsoft UK in an actual data center application as a WDM source for optical circuit switching. We also plan to showcase the technology to Huawei and Nokia Bell Labs who expressed interest in testing. Beyond field-testing with industry partners, the system will be shown at international industry trade fairs to address key stakeholders. The project aims to incorporate a dedicated startup to exploit the technologies. The IP position that EPFL has developed in microcombs and the recent spin-off LIGENTEC that offer SiN foundry service, make this endeavor realistic.

Keywords: optical frequency combs,integrated photonics,data centers