Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Polymer engineering via molecular design: embedding electrical and optical properties into VITrimers (VIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria,Italy,Uruguay,Italy,Argentina,Italy,Sweden,Malaysia,United States,Portugal
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-09-01
End date: 2026-02-28
Duration (months): 54.0
Total project cost (EUR): 1352400.0
EU funding (EUR): 1352400.0
Participants: 11
Project status: SIGNED

Plastics are strategic materials for several key sectors and the rethinking of plastics within the circular economy concept is pivotal for a more sustainable and resource efficient Europe. In particular, composites and thermosets, materials of choice for applications where long-term use and mechanical resistance are critical, cannot be mechanically re-processed since at elevated temperature they do not flow but degrade. A powerful new strategy to produce reprocessable cross-linked polymers is the functionalization of the polymer matrix with cross-links able to reverse or exchange at elevated temperatures. These covalent adaptable networks (CANs), also known as vitrimers, are able to shuffle chemical bonds through exchange reactions at high temperature, allowing for material reprocessing. To fully exploit the potential of vitrimers in high-end consumer goods, their properties need to be tailored to the specific application by embedding functional additives. Moreover, to accomplish vitrimer circularisation, such properties must also be preserved upon recycling. The VIT proposal intends to engineer vitrimers by endowing these polymers with highly desired functional optical and electrical properties, which are retained after recycling, fulfilling the circular economy paradigm “use-reuse-repair-recycle”. The VIT network gathers the expertise required to tackle this timely challenge. The consortium is composed of 10 high-level academic research groups from 3 different continents (Europe, America, Asia) and 2 highly innovative companies. By the seconding of 97 ERs/ERSs across Europe and worldwide, the aim is to capitalize on the consortium expertise in the chemistry and processing of functional materials to develop a new generation of advanced functional vitrimers able to satisfy the stringent requirements of reprocessability while preserving their properties.

Keywords: vitrimers,self reporting polymers,voltage stabilizers,cnss,polymer recycling
A cost effective 3D tomographic ultrasound technology for vascular diagnostics (piur tUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Germany
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-08-01
End date: 2015-10-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

piur imaging GmbH develops tomographic ultrasound solutions for the safe and cost-efficient image diagnostics of vascular diseases. piur’s expertise lies in medical devices, 3D imaging and image diagnostics. Each year cardiovascular disease (CVD) causes over 4 m deaths in Europe and 17.3 m deaths globally with numbers expected to grow to over 23.6 m by 2030. It accounts for 40% of deaths in the EU and costs the EU economy almost €196 bn a year. Ultrasound scanning imaging systems are currently the primary choice for vascular diagnostics. However, due to low sensitivity in the lower limbs, a limited field of action and poor quantification accuracy, patients are often referred for secondary scanning procedures such as computed tomography angiography, magnetic resonance angiography and catheter angiography for more detailed imaging. Referrals delay treatment, expose the patient to potential health risks and pose higher costs to healthcare providers. This presents a need to improve the rapidity and safety of the diagnosis of vascular conditions in patients to enable rapid treatment of conditions such as peripheral artery disease. There is also a need for cost effective preventative screening and surveillance to enable early intervention, for example, people at high risk of stroke. piur imaging has developed piur tUS, a 3D freehand tomographic ultrasound system capable of rapid, safe and accurate reconstructive 3D quantifiable vascular imaging. This system will provide a low cost and reproducible imaging solution that will reduce the need for referrals within the vascular field and be an effective tool for preventative screening and early intervention for people with CVD.

Keywords: ultrasound,diagnostic device,vascular surgery,imaging
The evolutionary origins and consequences of human-commensalism in Passer sparrows (EVOSPARROW)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 196400.4
EU funding (EUR): 196400.4
Participants: 1
Project status: CLOSED

Human-commensal species are almost constantly present in our daily lives; they are the mice in our fields or the sparrows in our gardens. The evolutionary trajectories of these species are intertwined with our own through the development of agriculture and human civilization, yet we know surprisingly little about their origins. My project, EVOSPARROW, will focus on Passer sparrows, including the House sparrow, one of the most ubiquitous commensal species. I will first use whole-genome resequencing to resolve the phylogeny of the Passer genus and provide context for the evolution of human commensalism. I will then make use of genomic data from over 120 individuals from across the Passer distribution to reconstruct the recent evolutionary history of sparrows in Europe. I will use coalescent models to test whether House sparrow migration into Europe is consistent with the introduction of agriculture during the Neolithic. The consequences of commensal relationships have rarely been studied in an evolutionary context. Yet comparisons between commensal and non-commensal lineages offer a means to understand the phenotypic and genetic basis of adaptation to human modified niches. I will quantify behavioural and morphological phenotypes between commensal House sparrow populations and a non-commensal House sparrow lineage occurring in the Near East, as well as other non-commensal Passer species. I will then scan the genome to identify the genetic basis of these phenotypes and quantify their segregation in the wild. With EVOSPARROW, I will develop an evolutionary framework to study how, when and dependency on the human niche arose in commensal species. Passer sparrows are the ideal system for this aim and with high-resolution genomic data, it is now possible to answer these questions. Through understanding the evolutionary origins and consequences of commensalism, I aim to also shed light on the development of our own civilization towards an agrarian society.

Keywords: speciation,human commensalism,passer sparrow,genome scan
non-structural landing gear parts made of composite (NSLGP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Israel
Call: Eco Design: High efficient non-structural landing gear parts based on advanced carbon fiber material systems and highly automated production technologies for helicopter and aircrafts. (H2020-CS2-CFP03-2016-01, 2016)
Start date: 2017-02-01
End date: 2019-07-31
Duration (months): 30.0
Total project cost (EUR): 627436.25
EU funding (EUR): 439205.38
Participants: 2
Project status: CLOSED

The objective of this proposal is to develop, manufacture and test non-structural landing gear parts for helicopter and aircrafts based on advance carbon fiber material system, the proposal introduce the methods, capabilities and resources of IAI and CirComp to fulfill the proposal requirements such as weight reduction, low cost production, and capability of the parts to sustain in harsh environmental, This proposal include activities of improving of the automated manufacture process, weight reduction by design optimization, assembly simplification and describe the certification process, innovation activities and common aims of IAI and CirComp are also introduce . The proposal describes also the expected impact during those activities, project structure, implementation and communication activities in this project

Keywords: landing gear,composite material,filament winding,door rod,linkage
Inheritance, expressivity and epistasis hidden behind the phenotypic landscape of natural populations (PhenomeNal)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: France
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-09-01
End date: 2025-02-28
Duration (months): 78.0
Total project cost (EUR): 1999882.0
EU funding (EUR): 1999882.0
Participants: 1
Project status: SIGNED

Elucidating the causes of the awesome phenotypic diversity observed in natural populations is a major challenge in biology. It is now clear that the understanding of traits is not only hampered by non-heritable factors such as the environment and epigenetic variation, but also confounded by the lack of complete knowledge concerning the genetic components of traits. More than a century after the rediscovery of Mendel’s law, the genetic architecture of traits still resists generalization. First, this is increasingly evident as shown by recent genome-wide association studies, where identified causal loci explained relatively little of the heritability of most complex traits, leading to the “missing heritability”. Second, we also have recently shown that monogenic mutations can display a significant, variable and continuous phenotypic expression, called expressivity, across different genetic backgrounds. Altogether, these observations clearly indicate that a better understanding of the genetic architecture of traits requires a deeper knowledge of the variability of the phenotypic effect of genetic variants across an entire population. In the frame of the Phenome'N'al project, I plan to marry classical but high-throughput genetic methods with new approaches based on population genomics to connect the phenotypic and allelic landscape by taking advantage of the powerful budding yeast model system. With our recent completion of the whole genome resequencing of over 1,011 natural isolates (http://1002genomes.u-strasbg.fr/), plus the accompanying phenotyping efforts, we have currently one of the best understanding of the natural genetic and phenotypic diversity of any eukaryote model system to date. These datasets will lay the foundation of Phenome'N'al, which aims to dissect the inheritance, expressivity and genetic interactions hidden behind the phenotypic landscape of an entire natural population.

Keywords: genotype phenotype,genome evolution,genetic diversity,evolution,yeast
Photonics for engineered quantum enhanced measurement (PEQEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 1497890.0
EU funding (EUR): 1497890.0
Participants: 1
Project status: SIGNED

Advances in measurement always lead to dramatic advances in science and in technology. Our society is now heavily dependent on the sensors that permeate environmental monitoring, security, healthcare and commerce. This is quantified by the global sensing market worth rising from $110 billion in 2015 to $124 billion in 2016, and is predicted to continue to rise to $240 billion by 2022. Now, our rapidly growing understanding of how to control quantum systems vastly expands both the potential performance and application for measurement and sensing using quantum-enhanced techniques. But these techniques will only efficiently find disruptive use once they are engineered for robustness, deliver desired operational parameters and are shown to work in a platform that can be mass-produced. This project adopts an engineering approach to the disciplines of photonic quantum enhanced sensing and squeezed light quantum optics. We will develop integrated photonics that are tailored to enable miniature, deployable and ultimately low cost sensors that exceed the state of the art through (i) exploitation of the quantum mechanics of light and by (ii) developing the requisite high performance of components in an integrated photonics platform. The methodology is to combine quantum optics of Kerr-nonlinear materials that generate squeezed light and quantum state detection with photonic device engineering. We will benchmark device performance using quantum metrology techniques. By the end of this project, we will have developed all-integrated squeezed light generation and detection technology, that provides enhanced sensors for absorption and phase measurements beyond the shot noise limit --- the hard limit that bounds performance of state of the art “classical” sensors. Applications include next generation quantum metrology experiments, measurement of photo-sensitive samples, precise characterization of photonic components and trace gas detection.

Keywords: silicon photonics,quantum metrology,sub shot noise measurement
Digital Platform for Construction in Europe (DigiPLACE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Italy,Spain,Germany,Spain,Italy,Belgium,Norway,Slovenia,Finland,France,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom,Luxembourg
Call: Digital Platforms/Pilots Horizontal Activities (H2020-DT-2018-2, 2018)
Start date: 2019-09-01
End date: 2021-05-31
Duration (months): 21.0
Total project cost (EUR): 999132.5
EU funding (EUR): 999132.5
Participants: 26
Project status: CLOSED

In modern economy, digitalization is a major driver of productivity growth across industries and services. However, the construction sector is lagging behind, even behind agriculture. The construction sector is characterised by a high presence of SMEs, low capitalization, a low rate of higher educated employees, low investment in innovation, and a long supply chain. Moreover, in the EU market, different languages, taxation, and regulatory frameworks are obstacles to Union synergies. DigiPLACE will exploit EU added value. Several initiatives have been developed at national level to improve the innovation in this sector. At EU level, some projects were devoted to facilitating the exchange of information, practice and knowledge (e.g. CPR 305/2011 and Levels). DigiPLACE will create a common ecosystem of innovation, standardization and commerce with the aim to collect the achieved results and to increase the productivity of the sector and the quality of its end products (building&infrastructure). Could digitalization help the sector to solve these historical issues and future ones? What kind of digitalization, what kind of market, what kind of production and supply-chain we could imagine? What kind of consumers do we have for our products and services. How do these worlds work together? DigiPLACE aims to investigate all these themes with a strong analysis of markets, actors and barriers. It will define a Reference Architecture Framework (RAF) for digital construction platform based on an EU-wide consensus involving a large community of stakeholders and the expertise of selected key players, resulting in a strategic roadmap for successful implementation of this RAF. DigiPLACE will rely on a large set of partners, linked 3rd parties and an Advisory Board representing leading European entities, companies and/or associations of industry, builders, owners (private and public), architects, research institutes, and ICT firms (for digital production, services and knowledge).

Keywords: digital platform,building information modelling bim,knowledge management
Fighting Insurgency, Ruining the Environment: towards an understanding of the causal relationship between conflict and forest fires (FIRE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

Despite the growing interest in the relationship between environmental degradation and political conflict, most discussions take the direction of causality for granted and try to understand whether or the extent to which environmental factors such as climate change-related drought lead or contribute to violent conflict. The aim of this project is to reverse the causality and look into how conflicts contribute to environmental degradation. It will do this by focusing on forest fires in the Middle East through a detailed study of the cases of Turkey, Syria and Israel. The questions that will be addressed in this context are: (1) Is there a positive correlation between inter- and intra-state conflict and forest fires? (2) How do conflicts affect ecosystems and biodiversity as well as the lives of inhabitants? (3) How are forest fires used discursively by conflicting groups? The proposed project is going to make a significant contribution to the existing literature in five ways: (1) It will explore whether actors deliberately damage the environment to gain the upperhand in a conflict; (2) it will focus on an underexplored aspect of the environment-conflict nexus, forest fires; (3) it will carry out fieldwork in three “non-European” cases which have spillover effects on European societies; (4) it will introduce novel techniques to the study of this problem, notably Geographical Information System (GIS) and digital Remote Sensing (RS); (5) it will combine “hard data” with qualitative analysis obtained through critical discourse analysis, elite interviews, and political ethnography to understand the political, economic and cultural dimensions of the environment-conflict relationship, thereby straddling the lines between natural and social sciences in a truly interdisciplinary spirit.

Keywords: environment,conflict,forest fire,environmental degradation,middle east,turkey,syria,israel
A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner (SCREENED)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Ireland,Italy,Italy,Germany,Belgium,France,Netherlands,United Kingdom
Call: New testing and screening methods to identify endocrine disrupting chemicals (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 5655088.75
EU funding (EUR): 5655088.75
Participants: 9
Project status: SIGNED

SCREENED will develop 3 different three-dimensional (3D) in vitro assays based on rodent and human thyroid cell constructs. At different level of anatomical complexity, these assays will increasingly mimic the structure and function of the native thyroid gland, ultimately achieving the replication of its vascular anatomy and morphogenetic characteristics: 1) a 3D organoid based on stem-cell derived thyroid cells, 2) a decellularized scaffold able to reproduce the biological composition of a native thyroid, repopulated by the 3D organoids, and 3) a bioprinted construct with the 3D organoids able to mimic the spatial and geometrical architecture of a native thyroid. These 3D assays will be hosted in a modular microbioreactor equipped with innovative sensing technology and enabling precise control of cell culture conditions. New superparamagnetic biocompatible and biomimetic particles will be used to produce “magnetic cells” to support precise spatiotemporal homing of the cells in the 3D decellularized and bioprinted constructs. The 3D assays will be used to screen the effect of endocrine disruptors (EDs) on the thyroid function in a unique biological sex-specific approach. Their performance will be assessed individually, in comparison with each other, and against in vivo studies. The 3D assays are expected to predict with more sensitivity and specificity the thyroid responses to different classes of EDs at low doses, compared to classical 2D in vitro assays or animal models. Supporting the “Adverse Outcome Pathway” concept, proteogenomics analysis and biological modelling of the underlying mode of action will be used to gain a mechanistic understanding of the chain of events from exposure to adverse effects on thyroid development and function. For future uptake, SCREENED will engage discussion with relevant stakeholder groups, including regulatory bodies and industry, to ensure that the assays are fit for purpose for ED safety assessment

Keywords: endocrine disruptors,3d cell culture,thyroid,organoids,decellularized extracellular matrix,bioprinting,organ on chip