Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Computation driven development of novel vivo-like-DNA-nanotransducers for biomolecules structure identification (iSenseDNA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden,Italy,Germany,Spain,Luxembourg,France
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-10-01
End date: 2027-01-31
Duration (months): 52.0
Total project cost (EUR): 3000418.5
EU funding (EUR): 3000418.0
Participants: 9
Project status: SIGNED

The link between the structural change of a molecule and its function is of fundamental importance since it provides direct insight on mechanism of complex biological processes. Recent years have witnessed noticeable advances of analysis of complex molecular conformations, however the understanding of their conformational dynamics remain a formidable challenge and revolutionary advances are still demanded the analysis of chemical composition and structure of biomolecules, however the understanding of their conformational dynamics remains a formidable challenge, and revolutionary advances are still demanded. Molecular machines, such as the DNA itself, which work at the core of many cellular activities, is able to DNA modify its conformation and to transduce the signal upon binding to specific proteins. In this project, we will develop a DNA-nanotrasducer for real-time detection of conformational changes and the analysis of molecular dynamics as it occurs in-vivo biological processes. The project aims to provide: (i) the development of DNA-nanotransducers that can perform both detection and conformational analysis of molecular dynamics in one functional unit (ii), Use bioinformatics approaches to predict 3D structure of conformational states modelling real time evolution of interacting DNA-NT and proteins, and machine learning (ML) models to directly link the atomistic structure, conformational state, and dynamics (iii) Assess protein-DNA-NT binding by experimental approaches using linear and “on-chip” non-linear spectroscopies for the detection of vibrational signatures of organic molecular systems, to recognize consequent structural changes in the optical signal in real-time, (iv) Describe DNA-NT/protein interactions at the cellular level and 3D analysis of DNA-NT and model proteins, towards drug discovery. These research efforts will provide a foundation for a next generation of DNA-nanotransducers to be used for high-throughput functional molecular structure.

Keywords: supercoiled dna dna molecular modelling conformational ensembles enhanced optical analysis on chip photonics
Diagnosis of large vessel occlusion (LVO) in acute stroke for improving access to treatment (LVOCheck)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 3960395.0
EU funding (EUR): 2772276.0
Participants: 1
Project status: CLOSED

LVOCheck is a portable diagnostic solution providing fast identification of large vessel occlusion (LVO) in acute stroke, just by analysing a blood drop from the patient's fingerpick. LVOCheck allows rapid triage of stroke patients already in the ambulance, so patients suffering a LVO can be directly driven to the closest thrombectomy centre to get the clot removed, without the need of a cranial CT scan at the nearest hospital. It avoids unnecessary patient transfers and waiting times, saving thereby an average of 2 hours from symptom onset to treatment. Our pilot studies have shown a clinical benefit of 15-20% more patients becoming asymptomatic or functionally independent. LVOCheck is a cost-effective, worldwide scalable innovation that will transform the triage and treatment of stroke patients, lessening the enormous economic and social burden of stroke. The use of LVOCheck will dramatically shorten the time from stroke onset to therapy, reducing disability, and saving lives.

Keywords: patient care,health related biotechnology,medical devices,stroke management,blood biomarkers,point of care diagnosis
Population interconnectivity and technological trajectories in southern Africa during the MIS3 through replicable lithic analysis (RStone)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Portugal,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 280873.44
EU funding (EUR): 280873.44
Participants: 3
Project status: SIGNED

Our species emerged from gene flow between structured populations across various regions of Africa. This process entailed intermitted events of coalescence and fragmentation, visible in late Pleistocene archaeological records through changing patterns of lithic technological similarity. In this framework, the MIS3 (59–28 ka) is a particularly intriguing period because archaeologists working in southern Africa have hypothesized that the marked regional variance in lithic technology is ascribable to cultural fragmentation and reduced information exchange among dispersed populations. However, it may also stem from the lack of a replicable system for recording and statistically analyzing lithic traits. The RStone project seeks to address this research challenge by pursuing three primary objectives. Firstly, it will develop a standardized method for recording lithic traits through comprehensive replicability experiments. Secondly, it will utilize this established recording system to collect novel lithic data from seven well-dated MIS3 stratigraphic sequences across Malawi, Mozambique, Namibia, and South Africa. Finally, it will conduct a quantitative inter-site comparison to explore techno-typological similarities and differences and determine whether the observed variance follows a pattern of isolation by distance or if other factors, such as geological constraints, played a role in shaping the way in which human foragers produced stone tools. This research will yield valuable open-source tools implemented in the R programming language and high-resolution datasets. In line with open science practices, RStone will prioritize the transfer and sharing of these resources, with a particular focus on engaging young African researchers. The extensive collaboration network will ensure a robust dissemination of results while positioning the fellow as a key figure in exploring the intricate interplay between human cultural diversity and population dynamics during the Pleistocene.

Keywords: lithic technology,african prehistory,msa,lsa,experimental archaeology,cultural transmission
Neuroendocrine Seeds of Obesity (NEURO-SEED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 289701.36
EU funding (EUR): 289701.36
Participants: 2
Project status: SIGNED

Obesity prevalence is dramatically increasing worldwide. The hypothalamus seem to be a pivotal brain structure in reversing obesity, as hypothalamic activation by incretin-based therapies (IBT) reduces body weight by 25%. However, the detailed functioning of the human hypothalamus in obesity remains unknown. Therefore, my overarching objective is to characterize hypothalamic structure and function in obesity. I will collaborate with clinical obesity experts at the University of Copenhagen and a pioneering MRI research team at Brigham and Women’s Hospital. The project includes three Work Packages (WPs), each addressing a gap in current state-of-the-art knowledge: WP1: Impact of IBT on hypothalamic signaling Hypothesis: IBT partially or fully normalizes meal-induced hypothalamic signaling to reverse obesity. Sub-objective: Map how long-term IBT affects hypothalamic signaling to the rest of the brain in a large randomized controlled trial of youth with obesity. WP2: Exploring the Impact of Oxytocin on Hypothalamic Structure and Function Hypothesis: Oxytocin reduces radiological indicators of hypothalamic inflammation associated with obesity and improves hypothalamic function. Sub-objective: Characterize hypothalamic structure and function in obesity and map the effects of four weeks of intranasal oxytocin treatment. WP3: Hypothalamic Responsiveness to Incretin Hormones Hypothesis: Hypothalamic responsiveness to incretin hormones is impaired in obesity. Sub-objective: Map the responsiveness of the hypothalamus to incretin hormones in people with obesity compared to people without obesity. The output of this project will elucidate key neurobiological mechanisms underlying obesity and inform the development of sustainable strategies to treat and prevent obesity. It will also facilitate critical knowledge exchange between European and U.S. research institutions and significantly advance neuroendocrine research capacity in Europe.

Keywords: hypothalamic function,obesity,functional magnetic resonance imaging,neuroendocrinology
Carbon Neutral European Battery Cell Production with Sustainable, Innovative Processes, 3D Electrode Design to Manufacture and advanced reaction analysis engineering- BatARang (BatARang)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Austria,Greece
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 18.0
Total project cost (EUR): 322515.0
EU funding (EUR): 322515.0
Participants: 2
Project status: SIGNED

The BatWoman project, for which this addition via Hop-On Facility is proposed, encompasses three primary objectives: (a) developing energy-efficient electrodes processed with a slurry of high dry mass content, devoid of volatile organic compounds (VOCs), (b) introducing an innovative dry room concept that reduces environmental impact while enhancing electrolyte filling efficiency and (c) implementing cost-effective and energy-efficient cell conditioning processes, including wetting, formation, and ageing. The project will utilize digital support to achieve these objectives, employing an AI-driven platform for intelligent re-tooling. This platform will continuously monitor the sustainability and efficiency of each production step, creating a battery data space and passport containing pertinent cell background information. This comprehensive approach is expected to reduce cell production costs by 63.5% and lower cell production energy consumption by 52.6%. CERTH's involvement via BatARang aims to strengthen BatWoMan's material and process characterization capabilities. Four analytic techniques will be employed to gain insights into the surface and intrinsic properties of the electrode structure, refining the optimization of the innovative dry-based mechanisms of the BatWoMan formulation. Specifically, CERTH’s work will: Improve the computational models of microstructural 3D electrode patterns through the provision of microstructural and porosity data to the implemented algorithms. Contribute to the development of sustainable manufacturing techniques by intrinsic microstructure characterization of the electrodes resulting from water-based formulations and dry processing. Enhance the advancement of innovative, sustainable, and cost-effective cell assembly processes by furnishing insights into the ageing and degradation mechanisms present in electrodes prepared under various assembly conditions.

Keywords: energy storage materials,characterization tools,cei characterization,sei characterization,degradation mechanisms
Mechanical regulation of the intestinal stem cell niche in development and disease (ENCODE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-06-01
End date: 2031-05-31
Duration (months): 60.0
Total project cost (EUR): 1937455.0
EU funding (EUR): 1937455.0
Participants: 1
Project status: SIGNED

Tissue turnover and regeneration are orchestrated by stem cells that both differentiate and self-renew. The balance between self-renewal, proliferation, and commitment depends on the stem cell microenvironment, or “niche”. Importantly, stem cells are not simply passive responders to their niches; instead, they play an integral role in building and communicating with their immediate microenvironment. Although multiple studies have described the molecular and cellular composition of the niche to date, it is still unclear if and how the mechanical properties of the microenvironment regulate stem cell emergence and maintenance. This research project investigates the intricate dynamics between mechanical cues, the stromal niche, and stem cell behavior within the context of intestinal development, pathology, and tumorigenesis. Using multidisciplinary methodologies, this study aims to uncover how the mechanical microenvironment influences the emergence of intestinal stem cells (ISCs) during development, with a focus on substrate stiffness, tension, compression and topology. Additionally, the research delves into the role of the stromal niche in Necrotizing Enterocolitis (NEC), a severe inflammatory disorder in preterm infants, seeking to elucidate altered stromal-ISC interactions that could contribute to the physiopathology of the disease. Finally, the project also explores the mechano-sensing function of PIEZO channels in colorectal tumorigenesis, investigating their impact on cancer stem cell properties and downstream signaling pathways.
Cytosolic Iron Delivery for Symbiotic Nitrogen Fixation (FeSYM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

Symbiotic nitrogen fixation (SNF) carried out by legume nodules is one of the most efficient ways of introducing nitrogen in natural ecosystems and in sustainable agriculture. It relies on the transfer of a relatively large amount of iron from the host plant to the endosymbiotic bacteria colonizing nodule cells, where it will be used as cofactor of many of the enzymes participating in SNF. However, the required steady iron supply for SNF is challenged by its low bioavailability in soil, prevalent in many of the main agricultural areas of the world. This is worsened by the hundreds of ferro-enzymes that compete for iron cofactors within a cell. Due to the relevance of SNF for a more sustainable agriculture, and the importance of ensuring iron supply to achieve this, a substantial effort has been done in understanding how legumes incorporate iron and deliver it to the nodules, and how it is used to synthesize nitrogenase cofactors. However, no information is available on how iron is specifically allocated to the nitrogen-fixing compartments. In this proposal we intend to study the mechanisms enabling targeted iron delivery to nitrogen fixation, particularly those events occurring at the cytosol and at the interface between the two symbionts. To do this, we will identify and characterize the proteins interacting the known symbiosome iron transporters. As a result, we will characterize the iron-interactome of these elements. These findings should not only increase our understanding of iron homeostasis in SNF and, more broadly, in plants, but also lead to dedicated iron delivery pathways for iron-biofortification or to engineer iron-proteins in plants.

Keywords: iron homeostasis,symbiotic nitrogen fixation,iron transport,legume,rhizobia,nodule,metallchaperone,plant microbe interactions,metal transport,iron nutrition,plant biology
BIOSOLUTION FOR GLOBAL MINERAL CRISIS AND INCREASED FOOD PRODUCTION WITHOUT CHEMICALS (BioRevolution)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Slovakia
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-06-01
End date: 2023-05-31
Duration (months): 12.0
Total project cost (EUR): 100000.0
EU funding (EUR): 70000.0
Participants: 1
Project status: CLOSED

ekolive is the first and leading provider of a new ecological bioleaching method (InnoBioTech®) for the ecological release of elements and the degradation of organic materials. This innovative technology replaces hazardous mining and processing methods, removes metals from industrial minerals in an ecological and economical way, and gives various industrial wastes a second life. At the same time, ekolive thus eliminates environmental hazards and cleans contaminated sites. In addition, the process creates a biofertilizer from the liquid residue that can completely replace hazardous pesticides, positively influences the taste of crops, and increases plant growth and yield by up to 100% and the dry mass of plants by up to 400% – for safe and healthy food production and sustainable agriculture. ekolive faces two challenges: The raw material challenge: The world-leading processing industry in the EU contributes to the transition towards a resource-efficient, sustainable society in line with the EU 2030 Agenda. For this, a sustainable supply of suitable raw materials is essential. However, despite enormous under- or untapped potentials of domestic primary and secondary resources, Europe is heavily dependent on imports – simply because there is a lack of suitable economic and ecological technologies to tap them. The challenges for a transition to sustainable agriculture – namely the reduction of the excessive use of chemical fertilizers and pesticides. These are not only dangerous to humans in many ways, but are also the cause of soil degradation, killed soil microflora, unhealthy and weak plants, contaminated food and drinking water. To answer these challenges, to promote the circular economy and to save resources, innovative, economically viable and environmentally friendly techniques are required. ekolive is the first to offer a corresponding biotechnology that can be used to make both mining and agriculture more environmentally friendly and sustainable.

Keywords: biotechnology,bioleaching,biofertilizer,minerals,bacteria,waste,circularity,sustainability,safe food
BLACK HOLE FEEDING AND FEEDBACK UNIFICATION (BlackHoleWeather)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 1999956.0
EU funding (EUR): 1999956.0
Participants: 1
Project status: SIGNED

BlackHoleWeather aims to unify the astrophysics of black-hole (BH) feeding and feedback within cosmic structures, in one comprehensive theory that leverages novel high-performance simulations, fundamental gas physics, and timely multiwavelength observations. Most of the ordinary matter in the Universe is in the form of a tenuous gas which fills galaxies, groups, and clusters of galaxies (circumgalactic, intragroup, and intracluster medium). Such cosmic atmospheres are shaped by complex thermo-hydrodynamical processes - akin to Earth weather - with the central BH acting as cosmic thermostat over scales of 9 orders of magnitude. We have entered a Golden Age of multiphase gas detections continuously discovering ionized filaments (optical/UV), neutral gas (IR/21cm), and molecular clouds (radio) which condense out of the hot X-ray halos or that are ejected via BH feedback. We will tackle key challenges of modern astrophysics: what is the origin and evolution of the macro precipitation; how the multiphase rain (or chaotic cold accretion) is fed down through the BH horizon; how matter/energy is re-ejected back by the BH and deposited via multiphase outflows, jets and radiation; what is the role of dust, turbulence, stars, and cosmic rays; and how the self-regulated BH feeding-feedback loop shapes galaxies throughout cosmic time. Bridging BH feeding and feedback via ab-initio, multi-scale (mpc to Mpc), and first-principle physics (magnetohydrodynamics, transport, chemistry, cosmology) is ambitious, yet it is a zero-to-one leap that current astrophysics must undertake, and whose public datasets will provide invaluable legacy for many astronomical communities. BlackHoleWeather is a frontier yet feasible project, exploiting the timely convergence of our groundbreaking massively-parallel GPU code (GAMER2) and our ongoing multifrequency observing programs (e.g., Chandra, XMM, HST, ALMA, MUSE, JWST, SOFIA, MeerKAT).

Keywords: black holes active galactic nuclei feeding,feedback magnetohydrodynamic simulations x ray optical radio observations galaxies,groups,clusters intracluster intragroup circumgalactic medium