Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Awareness and Migration: Organizations for bi-national family Rights Empowerment (AMORE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-07-01
End date: 2016-06-30
Duration (months): 24.0
Total project cost (EUR): 169800.0
EU funding (EUR): 169800.0
Participants: 1
Project status: CLOSED

AMORE (Awareness & Migration: Organizations for bi-national family Rights Empowerment) aims to bring an action-research approach to the study of migration policies and administrative practices regulating access to citizenship and residence permits. This project will focus on bi-national married families formed by a third country national (TCN) and a European Union (EU) citizen. A TCN is a citizen of a non-EU country who resides in a EU Member State, and is thus affected by a specific administrative practices and regulations. In bi-national families, these practices unexpectedly affect the EU spouse too. By focusing on the unintended consequences of migration policies for EU citizens, the question that this project addresses is at what point these policies and practices threaten family life freedom, considered a universal human right. While their problem is still largely unknown, bi-national family members are actively participating in bottom-up Civil Society associations to defend bi-national families and migrants' rights. Using the biographical policy evaluation method to achieve its goals, the project will compare different scenarios in three cities: Brussels, Strasbourg and Turin. In order to be effective and reduce variables, only one foreign nationality will be studied, namely migrants from Morocco (TCN) married to an Italian/Belgian/French citizen (UE citizen). The study of the impact of migrations policies on family members' experiences and strategies implies investigating also those public officers involved in the implementation of the administrative practices concerning these bi-national families and taking into account people from their social surroundings. After studying individual agency, the observation will be turned to associations that have competences to solve juridical cases and to carry out political lobbying involving directly those bi-national family members. This particular kind of association represents a form of active bottom-up citizenship.

Keywords: bi-national families - citizenship - third country national - biographical migration policy evaluation - hidden discriminations - civil society - bottom-up lobbying - agency
Smart entrepreneurial process for knowledge society (BGPROCESS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Estonia
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-05-01
End date: 2017-04-30
Duration (months): 36.0
Total project cost (EUR): 343868.0
EU funding (EUR): 343868.0
Participants: 1
Project status: CLOSED

Entrepreneurial process (EP) lies in the heart of new knowledge-driven globalizing (i.e. Born Global) venture creation. Born Global's are expected to support achieving the EU and national policy targets in economic development and unemployment reduction. Yet, studies of the EP have a gap between modest accuracy of the variance approach models and potentially lower generality of the process theory models. The General Objective of the BGPROCESS project is Bridging the gap between the variance and the process methodology to develop and validate a novel model of EP for new venture creation. To do so, we have established 3 Specific Objectives and split the work into 5 Work Packages, of which 3 are research oriented: 1. Theory development and model creation; 2. Model validation; 3. Application/Implementation tools development. The novel model of the EP combines the motivational, intellectual, mental and physical variables, decisions and acts of the entrepreneur into integrated stages and sub-processes. The qualitative phenomenological approach, theory development & modelling, qualitative and quantitative research on the sample of 150-200 SMEs in several countries will be used to achieve the General Objective. Implementation of the novel model in the international entrepreneurship theory is the basis for higher explanatory and predictive power of research on the EP of accelerated internationalization by knowledge intensive “born global” SMEs. The novel EP model, implemented in entrepreneurship development framework, enables the creation of reasoned and relevant policy, training and support-system development for knowledge-driven high potential SMEs and new ventures, to drive the economy thereof. Policy recommendations for the smart specialization and national innovation programmes, additional module for the national GEM survey, new modules for academia and practical training will be created. ACE-QUT will be the experienced host and UT the developing return host.
Involvement of the endocannabinoid system in posttraumatic stress disorder (CANNASTRESS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-07-01
End date: 2016-06-30
Duration (months): 24.0
Total project cost (EUR): 168794.4
EU funding (EUR): 168794.4
Participants: 1
Project status: CLOSED

Posttraumatic stress disorder (PTSD) belongs to the most frequent anxiety disorders. It develops in the aftermath of a traumatic life event and represents a clear public health problem. In spite of its increasing incidence, there are no established effective treatments for this disorder. In addition, even though a broad body of evidence concerning neurobiological correlates of this illness, the pathomechanisms of PTSD is still poorly understood. Therefore, there is a need to identify new therapeutic targets/strategies for PTSD. Interestingly, only 10-15 percent of the people confronted with a trauma develop PTSD in its aftermath. This points to the existence of highly efficient “salutogenic” (i.e. health promoting) factors. With the help of animal models we have accumulated preliminary evidence that the endocannabinoid system of the brain plays an important role in the modulation of processes occurring in PSTD and is pointed out as a potential therapeutic target for this neuropsychiatric disorder. The involvement of ECS in the development of PTSD symptoms seems to critically depend on the neuronal population affected. For instance, CB1 on glutamatergic neurons constrain the expression of fear responses, once the averseness of the test situation has surpassed a certain threshold. Therefore, the general objective of this research proposal is to unravel the time point, sites and consequences of attenuated CB1 buffered glutamate signalling in a mouse model of PTSD. To address this issue, we will combine genetic, in vivo imaging, electrophysiology, behavioural and biochemical studies in mice. The achievement of these objectives will provide new insights into the mechanisms underling the involvement of endocannabinoid system into the adverse consequences of a traumatic experience that might lead to the development of new therapeutic approaches for the treatment of PTSD that are based on downscaling glutamate release at presynaptic terminals.

Keywords: ptsd,spatial learning,freezing,startle responses,endocannabinoid system,cb1 receptor,glutamatergic neurons,hippocampus,manganese-enhanced mri,voltage-sensitive dye imaging,synaptic proteins
Asymmetric reactions of nitrile compounds: an approach to the synthesis of bioactive molecules (ARNIIF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-10-01
End date: 2016-09-30
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

This proposal, written jointly by Prof Iain Coldham (Sheffield, UK) and Dr Arghya Sadhukhan (Bhavnagar, India) details research in synthetic chemistry. The research will advance knowledge in the formation of single mirror image compounds based on a very recent discovery in the Coldham group on the stability of metallated nitrile compounds. Dr Sadhukhan has relevant experience in handling nitriles during his PhD studies and is extremely well placed to join this project. He will conduct research in synthetic chemistry to advance knowledge and understanding of the preparation of nitrile compounds with high selectivities. This is a very important area for synthetic chemistry, of relevance to the preparation of bioactive drug molecules. It is timely, as we have just published preliminary results in a high impact journal for chemistry communications (Angewandte Chemie). The University of Sheffield is well placed to advance this area, building on the experience of Prof Coldham. In addition, the Fellow Dr Sadhukhan will bring knowledge and skills of particular relevance that will enhance the standing of the European Research Area (ERA).

Keywords: organic methodology,asymmetric transformations,bioactive molecules,carbanions,nitriles
Design and validation of a conductive polymer-based system for the functional maturation of human pluripotent stem cell derived cardiomyocytes as a platform for drug testing (TIME TO MATURE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-10-01
End date: 2016-09-30
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

Despite the burden cardiovascular diseases impose on patients and healthcare systems, a curative therapy is lacking. One of the primary limitations is the ineffectiveness of current drug testing methods, which rely on individual cells or animal models. These systems lack the necessary reliability, as shown by the high rate of attrition that additionally increases the cost of drug development. Although cell reprogramming technology has been suggested as a potential solution that opens the path to personalized treatments, its application to the cardiac field has been hampered by the lack of maturity of the obtained cells. Our aim is to develop a drug screening platform by combining the human pluripotent stem cell (hPSC) technology with novel conductive polymers in the fabrication of a biomimicking cardiac niche. We will couple the specific characteristics of the niche, including stiffness, presence of adhesion motifs, mechanical strain and patterning of the substrate, with hPSC-cardiomyocytes (CM). In addition to the unique and physiological electrical stimulation the conductive polymers will transmit, the biofabricated niche will potently drive the maturation of hPSC-CM towards an adult phenotype, truly relevant for the screening of drugs. Our approach will assess the efficacy of this technology using an array of techniques. Importantly, we will introduce for the first time live cell Raman microspectroscopy to the evaluation of the dynamic process maturation. In addition, the creation of reporter hPSC lines enabling the genetic selection of chamber (atrial/ventricular) specific CM will provide high capacity of modeling the requirements of different cardiac diseases, endowing our platform with an unprecedented capacity of success. This proposal has a highly multidisciplinary character, uniting stem cell and material sciences with pharmacologic testing and drug development, and in close relationship with the industry sector.

Keywords: human pluripotent stem cells,cardiovascular disease,differentiation,cardiomyocyte,maturation,disease modelling,drug screening,conductive materials,tissue engineering,electrical stimulation
Multi-level analysis of the evolution of cooperative behaviour in social insects (EVOCOOP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-04-01
End date: 2016-03-31
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Cooperation is a fascinating process that is widespread in nature and which can be used to infer knowledge about basic mechanisms regulating complex behaviours. Cooperation is also a key milestone in the evolution of sociality: cooperative interactions among related individuals underpin the evolution of altruism and division of labour, two traits that have reached their highest expression in insect societies. However, the characterization of the molecular mechanisms underpinning cooperative behaviour has been mainly restricted to highly evolved social organisms that are study models in their field: e.g., the honeybee Apis mellifera, for social insects. In this project I will adopt a novel approach to understand cooperative behaviour in two social insects that have evolved different levels of sociality: the primitively eusocial paper wasp Polistes dominula and the highly eusocial fire ant Solenopsis invicta. To achieve my goal I will adopt a multi-level approach. First, I will focus on two important stages in the life history of social insects, i.e., colony founding and colony maturity. Second, I will use high-throughput RNA sequencing to characterize cooperative behaviour at the genomic level across levels of sociality (the sociogenomic approach). Third, I will investigate how cooperative behaviour is affected by two important ecological factors shared by these two insects: the biology of invasions and host-parasite interactions. Significant evidence suggests that invasive social insects escape from their natural parasites and pathogens and that the expression of cooperative behaviour increases on establishment in the invasive region. Both these factors are likely to be fundamental drivers of the great success shown by social insects in becoming invasive species. With this project I will characterise the sociogenomics of cooperative behaviour across fire ants and paper wasps, and provide valuable insight into the mechanisms that underpin social insect invasions.

Keywords: cooperation,behaviour,evolution of sociality,social insects,genomics,rna-seq,invasive species,host-parasite interaction,paper wasps,fire ants,pleometrosis,polygyny,colony founding
Networks and Narratives: The Transnational Community of European Studies 1957-2004 (ESNETNARR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

Challenges to elite accounts of European integration are central to the current EU crisis. It is therefore vital to understand how European elites construct these ‘narratives’. The proposed research will examine the transnational community of European Studies (ES) since 1957, as it had a crucial role in shaping these narratives. It will ask how the position of scholars within this network affected what they said or implied about the spatial reach and extent of integration. The project will integrate multilingual discourse analysis of narratives in canonical scholarly texts about enlargement, spatial differentiation and culture, with social network analysis (SNA) of this scholarly community’s transnational organisation. This SNA will use institutional, citation, CV and interview data. To de-centre Anglophone scholarship, and to examine the effects of transnational integration and relations between prestigious core locations (Germany and France) and less developed scholarly sites, the project will focus on the disciplines of political science, sociology and contemporary history in three case studies. These are the EC/EU accessions of the UK (1957-73), Spain (1975-86) and Poland (1990-2004). The applicant proposes an ambitious, original contribution to research on integration. He will publish several high-quality works, extend his transnational network of contacts and acquire crucial skills in postgraduate teaching, PhD supervision, management and research. New SNA and research interviewing skills will be vital for his innovative interdisciplinary combination of qualitative and quantitative methods. He will be based at Portsmouth University’s Centre for European and International Studies Research, which has excellent training facilities for early career researchers. He will work with Professor Wolfram Kaiser, a leading contemporary historian and interdisciplinary ES scholar with a research background in transnational networks, narratives and other relevant areas.

Keywords: eu enlargement,european integration history,european studies,narratives of european integration,scholarly network,transnational scholarly community
Shedding light on the diversity, ecology and evolution of enigmatic, uncultivated archaea using novel single cell and metagenomics approaches (ENIGMAARCHAEA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-10-01
End date: 2016-09-30
Duration (months): 24.0
Total project cost (EUR): 197811.6
EU funding (EUR): 197811.6
Participants: 1
Project status: CLOSED

The Archaea represent the Third Domain of Life and comprise a group of microorganisms that are important players in major biogeochemical cycles. Yet, even though more than 30 years have passed since their discovery, the biology, lifestyle and diversity of the archaeal domain of life remain to be poorly understood thus far, especially when compared to that of Bacteria and eukaryotes. Recent environmental surveys have revealed the existence of a vast, uncultured archaeal diversity, and the characterization of this so called “archaeal dark matter” is of great significance for understanding the diversity, biogeography and ecological relevance of Archaea in general, and the evolution of cellular life on Earth in particular. Yet, efforts to do so have been hampered by difficulties to cultivate these archaeal lineages under laboratory conditions. The current project aims to employ powerful, cultivation-independent approaches to genomically probe several deeply-branching archaeal lineages in order to set genomic standards for quantifying and defining archaeal taxonomic units, to determine molecular signatures of archaeal genomes, to reveal potential ecological functions of uncultivated archaea and to shed new light on the evolutionary relationship between Archaea and Eukaryotes. By combining state-of-the-art single cell genomics and metagenomics workflows with cutting-edge next-generation sequencing and bioinformatics pipelines, genomic data of several deep archaeal lineages will be generated and analyzed, focusing on the enigmatic Korarchaeota, as well as of representatives of the deeply-rooting Deep Sea Archaeal Group (DSAG) and the Ancient Archaeal Group (AAG). The proposed phylogenomic and comparative genomic analyses of these genomic datasets will reveal important novel insights into the enigmatic archaeal domain of life.

Keywords: archaea,origin of eukaryotes,comparative genomics,single cell genomics,metagenomics,uncultivated deep archaeal lineages,evolution,ecology,diversity,metabolism
Chemical Crosstalk: targets of interkingdom signals at the host-pathogen interface (CHEMICALCROSSTALK)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-05-01
End date: 2016-04-30
Duration (months): 24.0
Total project cost (EUR): 161968.8
EU funding (EUR): 161968.8
Participants: 1
Project status: CLOSED

The emergence of antibiotic resistance in bacteria, coupled with the rise in hospital-acquired infections, is a key problem for global health. There is an urgent need to discover antibiotics with novel modes of action to tackle multi-drug resistant strains and to complement current therapies. To this end, a better understanding of microbial virulence and the complexities operating at the host-pathogen interface is needed. This project aims to develop and apply novel chemical tools to understand interkingdom communication between bacteria and eukaryotic cells. A variety of human signals promote bacterial virulence and contribute to infection. In the first part of the project we will develop novel chemical probes to identify the receptors of human opioid signals in bacteria and employ these in a multidisciplinary approach to provide the first molecular level detail on these host-pathogen interactions. Furthermore, bacterial communication molecules are known to alter eukaryotic cell proliferation and promote infection. Therefore, in the second part of the project probes will be developed to understand the targets of these natural products in eukaryotic cells. Ultimately, this project seeks to address the broader question of how local conditions such as host stress contribute to the decision to switch to a virulence phenotype, and provide insight into whether modulation of interkingdom communication is a viable therapeutic approach.

Keywords: chemical biology,chemical proteomics,chemical probes,host-pathogen interactions,microbial virulence,bioorthogonal ligation,quorum sensing,interspecies communication