Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Engineering macromolecular self-assembly of hyaluronan (HA)-based glycopolymers with peptides (SUPRHAPOLYMERS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-03-01
End date: 2018-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Sugars and amino acids are natural building blocks which are used to form precisely regulated sequences in carbohydrates and proteins, respectively. While the field of proteomics has advanced immensely during the last past years, the field of glycomics is much less developed. The advance in synthetic polymer chemistry is allowing the possibility of controlling monomer sequences in synthetic macromolecules with diverse chemical structure providing many scientific and technological applications. “SuprHApolymers” project aims to design and synthesize glycopolymers mimicking the composition and structure of hyaluronan (HA), a linear polysaccharide composed of repeating disaccharide units of N-acetyl-glucosamine (GlcNAc) and glucuronic acid (GlcUA), but with many important biological functions. Linear glycopolymers, made solely of GlcNAc or GlcUA sugars (homopolymers) or containing both sugars (copolymers) will be synthesized to study their interaction with synthetic peptides bearing HA-binding motifs (peptide library). The synthesis of HA-based glycopopymers with branched architecture will be also attempted to explore different polymer configurations and to create optimal interactions with peptides. The self-assembly of HA glycopolymers with peptide amphiphiles containing selected HA-binding sequences will be investigated to form de novo peptide-polymer hybrid supramolecular materials with different molecular and macroscopic properties. Finally, the formed functional assemblies (nanostructures and supramolecular gels or films) will be explored for applications in synthetic biology and biomedicine.

Keywords: macromolecules,hyaluronan,glycopolymers,peptides,supramolecular chemistry,self-assembly,sequence controlled,synthetic chemistry,peptide-polymer interactions,nanostructures,gels,biomedicine
Dissecting the retinal inputs to behaviorally relevant computations in the central brain (VISUALCIRCUITS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-06-01
End date: 2018-05-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

A key function of the visual system is to extract behaviourally relevant features about the visual scene from the barrage of incoming photons. This process begins in the retina, a powerful image processer that recent studies have revealed separates the incoming information into ~20 distinct neural representations. Within central visual brain regions specific details of the visual scene are often neatly organized, remaining spatially segregated from each other. Despite our detailed knowledge of how information is organized within the visual system, progress in gaining a mechanistic understanding of how the brain is able to extract salient features from the visual scene, or how this information is used to guide behavior has stalled. Too often each brain centre is studied in isolation, meaning the details of its inputs and function of its outputs are frequently a point of conjecture. In particular, the input to central visual areas, despite the accumulated evidence, are repeatedly assumed to simply be a relayed representation of the visual scene from the retina. In order to provide mechanistic insight into how visual information is processed in central brain regions and understand how it is used to direct behavior this proposal will delineate the inputs, originating in the retina, to specific behavioural computations in central brain regions. This will allow us to determine which retinal channels are assigned dedicated computational tasks and how information from the retina is recombined to highlight key aspects of the visual scene used to direct behavior. To accomplish this conditional expression systems and trans-synaptic viral based circuit tracing will be combined with targeted patch-clamp recording and calcium imaging to link genetically identified cell types of the retina with behaviourally relevant computations in central brain regions. This work will provide insight into the circuit mechanisms used by the brain to process the visual world.

Keywords: visual system,retina,neural circuit,transsynaptic viral circuit tracing,two-photon calcium imaging,electrophysiology,superior colliculus
Mapping genetic information into physical space: shape growth in plants (GENEMECHMAP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-04-01
End date: 2018-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: TERMINATED

This Marie Curie Career Integration Fellowship will enable me to establish my own research group aimed at understanding shape growth through the interdisciplinary combination of biology, genetics, physics, and engineering. This proposal aims to decipher and connect the molecular and mechanical mechanisms underlying a special developmental boundary found at the plant apex - the crease that forms between the meristem (stem cell niche) and the new growing organ; the crease boundary is essential for proper plant form and development of lateral branches. The crease represents a uniquely formed tissue exhibiting negative Gaussian curvature, a saddle shape. The growth of such a shape is of principal interest. This proposal also aims to develop and utilize new methodologies for studying cell mechanics in plants, and to use these tools to link molecular players with mechanical outputs required for the generation of meristem-organ boundaries. The information gathered here will contribute to an understanding of how the mechanics of cell growth, and its molecular regulation, contribute to shape generation in plants. This information will serve as a scientific springboard for my career and my group members. This is a truly interdisciplinary project combining molecular genetics, plant physiology, cell wall biochemistry, materials science, engineering, and bioinformatics. The project will help to cement my career path catapult me to the top of this emergent and exciting field, plant biomechanics. It will also serve to enhance the profile of the UK and the ERA as leaders in interdisciplinary and innovative science. This project will benefit the ERA by: the ERA has an edge in this field which I will help maintain, my current ERA collaborations and those within the host institution will help to amplify the field, and my exposure to world class researchers across the ERA will have immeasurable benefits.

Keywords: plant biomechanics,cell wall,cell shape,meristem,organ,boundary
Higgs precision era at the LHC (HIGGSEFT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-04-01
End date: 2018-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

We are at a very special point in space and time. The Large Hadron Collider has experienced a first very successful physics run that culminated with the discovery of the long sought-after Higgs boson. We have begun probing the substructure of nature at unprecedented 10^(-17) cm distances, corresponding to the energy scales of the few TeV. The goal of this project is to develop a formalism to bring the study of the recently discovered Higgs boson into a precision era. With the discovery last year of a new resonance that is identified as the long sought-after Higgs boson with a probability better than 1-10^(-13), a new era started in the understanding of the Standard Model (SM) of particle physics. In the absence of any evidence for any other new degree of freedom at the weak scale, a mass gap is likely to separate the SM particles from the dynamics generating and stabilizing the Higgs potential. Our ignorance about the New Physics sector can thus be conveniently parametrized in terms of a set of higher dimensional operators built out of the SM blocks and obeying the simple SM symmetries laws. The Higgs data collected by the ATLAS and CMS experiments (as well as by the 2 Tevatron experiments) start putting interesting bounds on the 8 unconstrained deformation directions affecting the Higgs physics. Two lines of research will be developed in this project: 1/ the identification of the best variables to characterize the Higgs data in analogy with the oblique parameters that were introduced to study EW data, 2/ the computation of next-to-leading corrections for the Higgs production and decay rates in the presence of higher dimensional operators deforming the SM.

Keywords: high energy physics,theoretical physics,lhc,higgs,standard model,new physics
Laser Identification of Pollen and Bacteria in Air (LIPBA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Switzerland
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-06-01
End date: 2015-05-31
Duration (months): 12.0
Total project cost (EUR): 166991.77
EU funding (EUR): 148901.0
Participants: 1
Project status: CLOSED

This project aims at marketing a new laser based detector for identifying pollens in air, and further develop it for extending its application to the detection and identification of bacteria in air. Key markets are meteorological institutes for pollens and hospitals for bacteria identification, in order to address the problem of nosocomial infections. Business plans have been elaborated and even highlighted within the Mc Kinsey contest "Venture 2012", as one of the 20 finalists over 191 projects. Our bioaerosol detector also participated to the transatlantic campaign "Planet Solar" (www.planetsolar.org/deepwater) over the ocean for 6 months, and demonstrated its exceptional reliability and measurement quality. It also provided an extremely broad media coverage and thus worldwide visibility to our project.

Keywords: 291201
Novel Hydrogen Storage System (H2STORES)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Israel
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-07-01
End date: 2015-06-30
Duration (months): 12.0
Total project cost (EUR): 167010.4
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

In the project H2StoreS, standing for novel Hydrogen Storage System, a proof of concept (PoC) of novel liquid-organic hydrogen carrier (LOHC) technology will be conducted. The aim of this PoC is to create and document the technical and business environment analysis- based evidence of near term commercial potential of this novel hydrogen storage system. Moreover, another important goal of this project is to find the right post-PoC phase technology development, commercialisation and funding partners, and to convince them in investing funds and effort in this technology. Molecular hydrogen (H2) is a very attractive clean, renewable fuel, which can also be used for energy storage and heating systems. H2 is currently stored in high-pressure or cryogenic tanks. However, these solutions are not suitable for most commercial applications because of their low energy density, high price and safety issues. All these problems can be avoided using LOHC systems and consequently, there have been a lot of research and development efforts in this field during recent years. The ability to store and transport H2 within a liquid carrier at standard temperatures and pressures provides many advantages over current H2 storage methods; the need for large storage tanks is eliminated, major changes in the fuelling infrastructure are avoided and the risk of explosion is minimised. However, although significantly more cost efficient than high-pressure or cryogenic tanks, current state-of-the-art LOHC systems remain too expensive for a large-scale consumer use of H2. Within the preceding ERC project, a liquid-organic hydrogen storage system was discovered, which provides significant technical and commercial advantages and has the potential to enable the large-scale use of H2 as an energy storage vector.

Keywords: 246837
Cooperative Infrastructure Redundant Positioning by Consumer Devices - COREPOS (COREPOS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Sweden
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-05-01
End date: 2015-04-30
Duration (months): 12.0
Total project cost (EUR): 165187.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

More than 150 people die due to avalanche accidents every year; this figure could be drastically reduced were the victims to be swiftly localized: the survival rate is 90% if rescued within 15 minutes, but decreases to 25% after 45 minutes, due to asphyxiation. Various specialized localization devices exist, but are typically difficult for the average user to operate, and the penetration among skiers is low. At the same time, the introduction of so-called smartphones is revolutionizing the use of mobile services and applications. Connecting clusters of smartphone which are in close proximity to each other offers the opportunity to solve localization problems which previously would not have been possible. These facts together motivate the initial focus of COREPOS: an app that can be installed on a consumer device such as a smartphone, which transforms the device into an independent positioning device. The localization system will only be dependent on the signals transmitted and received by the user devices themselves - thus our proposed system will be redundant of any external infrastructure. Avalanche positioning is just the first step of the proposed system; COREPOS aims to develop software libraries that can be used to locate peers. These software libraries will be licensed to interested parties, and are thus to be embedded in a multitude of application verticals. This is an application area with big commercial as well as societal benefits. The unique principle in COREPOS is that the peers are, in addition to supplying data, also instructed on how to move in order to maximize localization performance

Keywords: 228044
Calibration of extreme wave measurement on the ocean surface (WAVEMEASUREMENT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Ireland,France
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-09-01
End date: 2016-02-29
Duration (months): 18.0
Total project cost (EUR): 152400.0
EU funding (EUR): 139140.0
Participants: 2
Project status: CLOSED

Our idea is to revisit the recording of time-series of sea surface elevations in extreme conditions. A better understanding of extreme waves is vital in harbour and coastal monitoring, coastal engineering, offshore design and operations, maritime traffic control, meteorological and climatological studies, wave and wind energy studies. Within the framework of the ERC Advanced Grant MULTIWAVE, which started in April 2012, we brought new physical and mathematical insights into the dynamic shaping mechanisms and statistics of rogue waves, both in optics and in hydrodynamics. While in optics the measurement of such extreme events is accurate, the measurement of extreme waves in the ocean is quite delicate. Moreover experiments can be repeated in optics while in the ocean one has to wait for extreme waves. There are several techniques to measure waves in the ocean: the traditional in-situ techniques as well as remote sensing or optical techniques. They all have advantages and drawbacks and none of them has ever been calibrated against extreme ocean waves. We believe that the in-situ technique once improved remains the best technique for now. Together with the industrial subcontractor, we will optimize wave buoy sensor technology for extreme waves. Based on the fundamental know-how from MULTIWAVE, we are in a position to allow settings to be optimized in the initial design phase prior to ocean deployment and then to test the performance of the optimized device. We will select areas off the west coast of Ireland and times of the year when the probability of recording extreme waves and rogue waves in particular is the highest. If the recorded time-series are robust and accurate, the new wave buoy will be the first wave buoy that can be trusted for recording extreme waves. A market search of existing wave measuring devices currently available will be performed. We believe that the potential market is huge.

Keywords: 290562
Development of Proteomimetics as Drug Discovery Screening Tools (PROTEOSCREEN)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: United Kingdom
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-08-01
End date: 2015-07-31
Duration (months): 12.0
Total project cost (EUR): 153458.3
EU funding (EUR): 138273.0
Participants: 1
Project status: CLOSED

The objective of ProteoScreen is to demonstrate Proof of Concept that proteomimetics can be exploited as (a) a surface based screening platform and (b) a tool for in cellulo target ID. In doing so I will demonstrate commercial use of the Proteomimetic technology developed in the ERC ProteoFold project.

Keywords: 240324
High-throughput real-time characterisation of cell-mechanical properties (FASTTOUCH)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Germany
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-07-01
End date: 2015-12-31
Duration (months): 18.0
Total project cost (EUR): 165775.6
EU funding (EUR): 149549.84
Participants: 1
Project status: CLOSED

We aim to commercialise a new, patent-protected concept to measure mechanical properties of biological cells with flow-cytometer-level throughput and establish its standard application in modern drug development and medical diagnostics. Mechanical properties have recently proven to be a physiologically relevant indicator to determine the state, function and type of biological cells. Analysing mechanical parameters provides a novel method to identify physiological or pathological changes. However, mechanical cell properties are currently not accessible for large-scale applications demanding high-throughput. We developed, designed and realised a hydrodynamic cell stretcher, a microfluidic-based device for analysing mechanical cell properties at rates above 100 cells per second and therefore three orders of magnitude faster than other existing methods. In the proposed project, we want to identify, test and validate the most promising applications of hydrodynamic cell stretching in clinical and pharmaceutical research.

Keywords: 282060
Flexible Speech Recognition System (FLEXSR)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: United Kingdom
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-10-01
End date: 2016-03-31
Duration (months): 18.0
Total project cost (EUR): 165780.4
EU funding (EUR): 148579.0
Participants: 1
Project status: CLOSED

The present idea is to convert a research tool of the ERC-funded project (269670) into a working single-word Automatic Speech Recognition (ASR) demonstration system to attract speech technology companies to use this method in commercial ASR systems. The difference to existing ASR systems is that no training is needed; a wide range of speakers and dialects are covered; it can handle non-standard, non-ideal speech; it is less susceptible to interference from noise; and the system can be easily adapted to new languages. Our planned ASR system [the Flexible Speech Recognition system (FlexSR)] has evolved from a linguistic model of phonological representation, which is the focus of the present ERC grant.

Keywords: 269670
Proof of Concept for Rethinking Tunnels in Urban Neighbourhoods (RETURNPOC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Ireland
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-06-01
End date: 2015-05-31
Duration (months): 12.0
Total project cost (EUR): 168132.0
EU funding (EUR): 149917.7
Participants: 1
Project status: CLOSED

This proposal will develop cutting-edge technology to better link two rapidly growing industries: laser scanning (aerial and terrestrial) and three-dimensional printing. The solution will circumvent the current methods, which rely upon an intermediary Computer-Aided Design programme. By direct transformation of the data points into printable surfaces, greater levels of automation can be achieved, while producing superior results. Furthermore the intended solution will enable the integration of previously disregarded semantic data such as colour and intensity. For architecture, civil engineering, and urban planning, the resulting technology will offer the immediate benefits of an order of magnitude reduction in time and cost. The proposed innovation is enabled by the immediate access to extremely high quality aerial and terrestrial laser scanning that was collected through the original ERC RETURN grant.

Keywords: 307863