Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrating genomics, epidemiology and evolution to accelerate tuberculosis eradication (TB-ACCELERATE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Spain,Spain
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-07-01
End date: 2021-06-30
Duration (months): 72.0
Total project cost (EUR): 1671875.0
EU funding (EUR): 1275875.0
Participants: 2
Project status: CLOSED

When the scale of the tuberculosis (TB) epidemic was highlighted by its declaration as a "Global Emergency" by WHO in 1993, it was envisaged that the efficient use of existing tools would result in a progressive decline towards eradication. This has not occurred. At the current pace of decline in TB incidence the Millennium objective to eradicate it by 2050 will not be met. Predictions of epidemiological models were inaccurate and current control programs and technologies have shown their limitations to control the transmission of the disease. To overcome these limitations we need a technological, methodological and conceptual leap forward that can reveal the unknowns of TB epidemiology. I propose whole genome sequencing (WGS) as the technology that can mediate this advance. While WGS has been applied mostly to retrospective datasets I propose to use it in prospective samples from a low-burden region at a population scale. Genome information will fill the gap between epidemiology and evolution to have a direct impact on public health. This will allow to develop innovative methodologies to describe transmission at an unprecedented resolution and as a consequence to differentiate among risks factors associated to the bacteria, the host, the environment and their interactions. Elucidation of these factors will lead to better models used to design new strategies and accelerate global TB eradication. In addition, I will show how the real-time integration of data in public eHealth systems combined with in situ interventions will accelerate TB eradication. The strength of the project resides in its multidisciplinary approach to TB epidemiology that will provide answers to yet-out-of-reach questions. It will lead to improving health status at the local level as well as to epidemiological and control programs at a global scale. In summary, the project will open new ways to foster the long sought outcome of the tuberculosis community: TB eradication.

Keywords: whole genome epidemiology,tuberculosis transmission
Innovative offshore safety system to protect the body from cold shock in extreme conditions (Centurion 3)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-01
End date: 2020-02-29
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Every year 360,000 people die worldwide as a result of drowning, making it the third leading cause of unintentional injury death worldwide, accounting for 7% of all injury-related deaths. Globally, Immersion in cold water is the second most common cause of accidental death, at present 98 % of drowning deaths are caused by cold-water immersion., 3000 deaths. People working offshore who uses helicopters as their daily transportation faces the 80% risk of drowning when helicopter crashes or accidents occurs. As a matter of fact, air transportation is reported to be the leading cause of fatalities and accidents wherein 73 incidents were alone reported in UK wherein cold-water drowning being the primary cause of death. This garment should allow buoyancy in water and protect from fire. Nevertheless, it currently has very little or no thermal property. For workers in cold waters, the law requires to wear 3 layers of clothing beneath the suit during winter and 2 layers during summer. Such under-suit clothing is inadequate for safety in case of contact with water (e.g. flight crash or simply a fall in the water). Iron Ocean proposes Centurion 3, the next-generation 3-layer upper body garment with integrated self-heating thermal gel system, specifically engineered to protect the upper body from cold shock. It can be comfortably worn under a safety suit to guarantee comfort and thermal protection in case of extreme environmental conditions. The clothing thermal properties are given by Iron Ocean’s engineered advanced thermo-chemical gel which actively produces heat upon contact with water. During the phase 1 feasibility study, Iron Ocean will establish a sound go-to-market strategy and supply chain, and will outline further development plans. In the second phase of the innovation project, Iron Ocean will improve the ergonomic and flexibility properties of the material, establish an in-house production line for gel and validate the solution with offshore workers.

Keywords: thermal garment,thermochemical gel,cold shock,cold protection,offshore,safety,thermal,protection,renewable energy,oil and gas,offshore wind power
Relationship of Somatic Structural Variation Mosaicism to Aging and Disease Phenotypes (MOSAIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2019-02-01
End date: 2024-01-31
Duration (months): 60.0
Total project cost (EUR): 1997060.0
EU funding (EUR): 1997060.0
Participants: 1
Project status: SIGNED

Advances in DNA sequencing technology, enabling routine genetic variation studies, have uncovered that genomic structural variants (SVs; e.g. deletions and inversions) account for most varying bases in human genomes. SVs are also disproportionally associated with disease phenotypes when compared to single nucleotide variants by number. Studies are increasingly implicating genetic polymorphisms with diseases – yet why some humans develop diseases while others do not, and why disease incidences often increase with age, is largely unclear. Intriguingly, recent studies showed that human genetic variation extends markedly beyond heritable variants. Soon after fertilization, mutations naturally accumulate in healthy tissues resulting in somatic genetic mosaicism (SGM), a highly understudied form of variation. Among SGM classes, ‘SV mosaicisms’ likely account for most varying bases, are increased at age, are seen in the context of clonal cell expansion, and are associated with diseases of the elderly including type 2 diabetes and cancer. This indicates that to understand the basis of particular diseases we may first need to comprehend how naturally formed somatic SVs impact human cells. Here we aim to uncover the extent and impact of SV mosaicism. We aim to pursue single cell analyses, which offer the most direct way to detect somatic SVs in individual cells. Performing SV analysis in single cells at scale, however, is not a mainstream approach: current methods identify copy-number variants (CNVs), but miss key copy-neutral SV classes (e.g. inversions) likely to be highly relevant. We aim to develop new experimental and computational tools to construct a single cell catalog of a wide variety of relevant SV classes in different cell types (i.e. the blood compartment and skin) and ages. Using this catalog, we aim to study the functional impact of SV mosaicism on the cellular level, as a foundation for elucidating roles of somatic SVs in age-related phenotypes and diseases.

Keywords: genomic structural variation,somatic genetic mosaicism
HYBRID QUANTUM-DOT/TWO-DIMENSIONAL MATERIALS PHOTOVOLTAIC CELLS (NANOSOLAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-02
End date: 2017-06-01
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

The development of high-efficiency and low-cost solar cells is one of the most crucial challenges to secure a clean and sustainable energy source. The novel and tunable optoelectronic properties of nanomaterials are a very promising but still challenging route to achieve this goal. In this project, we propose to combine the advantages of two important nanoscale materials, semiconductor quantum dots (QD) and two-dimensional atomic layered (2-D) materials, to realize high-efficiency hybrid solar cells. Quantum dots are one of the best absorbing and carrier photogenerators due to multiple exciton generation and their size-tunable and direct band gap, however, their poor dot-to-dot conductivity has been a major limitation for photovoltaic devices. We propose to overcome this limitation by intercalating 2-D materials that have shown high charge mobility and strong optoelectronic properties. We propose a tandem configuration based on a stack of QD layers for strong carrier photogeneration, with intercalated 2-D atomic layers for efficient charge and photocurrent extraction. We will study the charge transfer and separation at the interface of QDs and 2-D layers, both of which are strongly affected by quantum confinement. The co-supervisors of this project, Prof. Konstantatos and Prof. Koppens at ICFO, have demonstrated a QD/2-D(graphene) phototransistor with a photoresponse up to 5 orders of magnitude higher than phototransistors based on single graphene or MoS2 atomic layers without QDs, showing the potential of QD/2-D hybrid devices for photovoltaics. In addition to QDs, we will also use small band gap materials, such as phosphorene and other 2-D semiconductors that can harvest energy from infrared hot sources in dark conditions. The proposed hybrid QD/2-D solar cell architecture can have a strong technological impact since both materials can be produced in large scale by chemical synthesis and surpass the performance of current photovoltaic technologies.

Keywords: photovoltaics,solar cells,quantum dots,two dimensional materials,graphene
5G European Validation platform for Extensive trials (5G EVE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Italy,Italy,Italy,Spain,Italy,Greece,Greece,Poland,Romania,Greece,France,France,France,France,France,United Kingdom
Call: 5G End to End Facility (H2020-ICT-2018-1, 2018)
Start date: 2018-07-01
End date: 2021-06-30
Duration (months): 36.0
Total project cost (EUR): 15742222.5
EU funding (EUR): 15737785.0
Participants: 34
Project status: CLOSED

We are at the “eve” of a fundamental transition in 5G, and the aspiration of 5G-EVE is to create the foundations for a pervasive roll-out of end-to-end 5G networks in Europe. 5G-EVE supports this fundamental transition by offering to vertical industries and to all 5GPPP Phase3 projects facilities to validate their network KPIs and their services. Important representatives of these vertical industries are directly involved as partners of 5G-EVE exactly to influence the design of the end-to-end 5G services, and to provide an early assessment. The 5G-EVE end-to-end facility consists of the interconnection of four 5G-site-facilities (France, Spain, Italy, Greece), which have been selected because of their considerable previous work with vertical industries and standardisation bodies, on top of their 5G technology competences. 5G-EVE aims at creating synergies between a significant number of facilities that will ensure sustainability and impact in terms of exploitation. The 5G-EVE facility will enable experiments with: (a) heterogeneous access, including NR, licensed/unlicensed spectrum, advanced spectrum management; (b) Mobile Edge Computing, backhaul, core/service technologies; (c) means for site-interworking and multi-site/domain/technology slicing/orchestration. 5G-EVE will be initially compliant with 3GPP Rel. 15 and, later on, with Rel. 16. Industrial verticals will be facilitated in the specification/analysis of experiments through: (a) intent-based, and other high-level, interfaces; (b) means for advanced 5G testing, i.e., for KPI analysis, technology benchmarking, performance diagnosis. A VNF pool, including open source and proprietary, radio/network/service, components will be developed and made available. 5G-EVE will impact standards, and has the potential and strategy for ensuring the sustainability of the facility beyond the project lifetime, therefore becoming a cornerstone of the 5G PPP programme and beyond.

Keywords: validation,testing,industrial
Transport of Heat in hEteRogeneous Media (THERM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Geothermal represents a promising energy source to satisfy the growing energy needs with only minimal environmental impacts. To develop and test new technologies for energy production and storage in geothermal reservoirs, deep understanding of heat transport in fractured media is critically needed. The THERM project focuses on the investigation of heat transport and associated thermo-hydro-mechanical (THM) processes occurring during the lifetime of a geothermal reservoir. Fractured reservoirs, such as those found in enhanced geothermal systems, are characterized by a strong hydraulic and transport complexity coming from the fractures’ surface roughness, from their arrangement in networks, and from the interaction of the fractures with the surrounding rocks. As a result, the characteristics of the hydro-thermal flow which occurs when a cold fluid is injected into a hot fractured rock mass are controlled by fracture network discontinuities and properties of fracture surfaces themselves. While progresses have been made in characterizing and modeling subsurface heterogeneity in flow and solute transport processes, the effects of multi-scale subsurface heterogeneities on heat transport remains an open question. I propose new 3D fully coupled physical-based numerical models at different scales associated to state-of-the-art field experiments to develop a quantitative understanding of complex coupled processes occurring along fluid-rock interfaces during fluid circulation in geothermal systems. The main objectives are (i) to characterize the combined effect of fracture-scale and network-scale heterogeneity on flow and heat transport phenomena, and (ii) to design new field experiment to jointly measure the integrated THM behavior of fractures. Thanks to THERM, the ER will receive a unique multidisciplinary scientific training by Rennes 1 University that will reinforce significantly her expertise for future research activities and open new perspectives for career.

Keywords: hydrogeology,geothermal energy,fractured media,heat transport,heterogeneous porous media
KEY ACCOUNT MANAGEMENT AND ENHANCING INNOVATION MANAGEMENT CAPACITY SERVICES FOR LITHUNIAN SMEs (SME Coach LT 2018)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Lithuania,Lithuania,Lithuania
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 38333.75
EU funding (EUR): 38333.75
Participants: 4
Project status: CLOSED

The aim of SME Coach LT 2018 is to increase effectiveness and efficiency of investment in R&D and Innovation by enhancing innovation management capacity of the Lithuanian beneficiaries of the funding schemes SME Instrument, Fast Track to Innovation ( FTI) and Future and emerging technologies (FET Open) under H2020 and SMEs with significant innovation activities and a high potential for internationalisation. Specifically, the project will support beneficiaries of the SME instrument in identifying project-specific barriers and weaknesses and gaps in their innovation capacities that hinder realization of growth opportunities and point to suitable coaches to address the identified weaknesses. The Key Account Manager will support SMEs SME Instrument beneficiaries in identifying critical issues and gaps with regards to their innovation idea and guide them to relevant lead coach who will support the company throughout their innovation journey. To identify SMEs challenges, the Key account Manager will use a holistic and dynamic business innovation model, supported by Business Innovation Roadmap Tool, available under Creative Commons License from smE-MPOWER network. The second specific objective aims at SMEs that have significant innovation activities and a high potential but lagging innovation management capacities. To assess the performance of their innovation management system, we will use IMP3rove Academy’s diagnostic tool or similar tools. Further action plan will be developed. In supporting SMEs we will use action- based (and case-driven) learning approach to addressing identified gaps in the innovation system. smE-MPOWER tools will help support the coaching process.

Keywords: sme instrument,coaching,innovation management
Unlocking excellence in research and innovation in neurobiology and neurological disorders at IBMC/I3S (NCBio)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: ERA chairs
Theme: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Portugal
Call: ERA Chairs (H2020-WIDESPREAD-2018-2020-6, 2019)
Start date: 2021-01-01
End date: 2026-12-31
Duration (months): 72.0
Total project cost (EUR): 2479972.5
EU funding (EUR): 2479972.5
Participants: 1
Project status: SIGNED

Our limited understanding of the cellular and molecular basis of the Nervous System, together with the divergent and complex traits of Neurological Disorders, is a major obstacle in finding therapeutic solutions for this group of diseases. At IBMC/i3S, many of the groups developing their work in Neuroscience are focused on neurodegenerative disease, from the identification of disease-causing mechanisms, to drug-discovery and preclinical and clinical studies. The lack of a strong research programme on Basic Neural Cell Biology has been identified by the institute as a major handicap to implement the full potential of the work performed in the field of Neuroscience. Responding to this need, the main objective of NCbio is to recruit and maintain an experienced researcher and research project manager in the field of Neural Cell Biology (ERA Chair Holder), as well as her/his scientific team that will establish a new research group at i3S/IBMC. The Neural Cell Biology research group led by the ERA Chair Holder will provide excellence and trigger innovation in this particular area and will modify the R&I landscape in Neurobiology and Neurologic Disorders at the institute with a positive impact on the region and Portugal. In addition to the structural changes in R&I brought by the ERA Chair Holder, she/he will also help tackle other weaknesses and leverage opportunities IBMC/i3S has, through measures like: • Capacitation of research teams in scientific and in research administration and grant preparation matters, addressing also the technical teams on this latter aspect; • Upgrade of existing IBMC/i3S Doctoral programmes through the creation of a Neural Cell Biology PhD offer; • Engagement of stakeholder communities to help the institute and the external stakeholders achieve higher added value for their activities and results, while positioning IBMC/i3S and its research closer to the market (including the operation of the Neural Cell Biology Stakeholder Hub).

Keywords: neural cell biology,neuroscience,neurobiology,neurological disorders,neurodegenerative disorders,excellence,era priorities
EXtending Interface Science To Atmospheric-pressure Reactions (EXISTAR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 1491265.0
EU funding (EUR): 1491265.0
Participants: 1
Project status: SIGNED

This project aims to deliver a step change in our understanding of electrode and catalyst interfaces, by pioneering operando measurement capabilities that can reveal the chemistry and structure of functional interfaces under working conditions in liquid and gas environments at atmospheric-pressures and above. We will exploit enclosed reaction cells sealed with X-ray, electron and neutron transparent windows, extending their operation to conditions of temperature and pressure where industrial catalytic reactions occur, as well as the liquid environments of electrochemical energy storage. These cells will be portable across complementary characterisation tools to reveal the chemical and structural evolution of material interfaces during operation. Solid-liquid studies will focus on electrode materials for Li-ion batteries, that are critical to energy storage for a low carbon economy. This will reveal the degradation mechanisms that lead to capacity fade across varying conditions of stress (T, voltage, rate) during electrochemical cycling. Solid-gas studies will focus on heterogeneous catalysts for sustainable production of useful chemical feedstocks from environmentally harmful waste streams. We aim to reveal the nature of the active sites in catalysts used for chemical synthesis from carbon dioxide, and understand how combining these catalysts with oxide supports influences their activity and selectivity. Relationships will be established between the interfacial structure and function of these materials in terms of their electrochemical cycling performance and catalytic activity/selectivity. This will ultimately inform the design of new functional materials for use in technologies that are critical to a sustainable economy. The scope for research problems that can benefit from this atmospheric pressure operando approach is vast, providing many future research opportunities.

Keywords: batteries,energy storage,x ray spectroscopy,catalysis