Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Inflammation in human early life: targeting impacts on life-course health (INITIALISE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Finland,Sweden,Italy,United Kingdom,Netherlands,United States,Spain,Germany,Croatia
Call: Personalised blueprint of chronic inflammation in health-to-disease transition (HORIZON-HLTH-2022-STAYHLTH-02, 2022)
Start date: 2023-01-01
End date: 2028-12-31
Duration (months): 72.0
Total project cost (EUR): 7451043.75
EU funding (EUR): 7451043.75
Participants: 12
Project status: SIGNED

The development of the human immune system in early life, including in utero, impacts the risks of several diseases later in life, particularly immune-mediated diseases such as allergies, asthma, and autoimmunity. Yet, the mechanisms of early life immune imprinting have been poorly understood in humans due to the difficulty in obtaining samples and the challenges of deriving the most important data from small sample volumes available. Furthermore, these studies are complicated by the many simultaneous exposures with potential impact on developing immune cells, colonising microbes, and immune-microbe mutualism. To better understand such interactions, a combinations of large population studies with longitudinal data and long-term follow-up and more detailed studies in smaller sets of children will be needed. Here we propose such a combined and interdisciplinary approach by intersecting multiple cohorts and existing biobanks, applying state-of the art technologies for exposure analyses and immune system investigation. This will enable us to understand the environmental factors shaping human immune systems early in life, their mechanisms of action, and impact on life-course health. The specific objectives of INITIALISE are: 1. to elucidate how exposures and genome impact gut microbiome, host immune system and metabolism, and how the interplay of these factors impact life-course health. 2. to define the role of the maturation of the immune system as a mediator between exposures and life-course health. Functional studies will be performed, to test specific mechanisms of environmental factors differing among children with different health outcomes and their imprinting on developing immune cells. 3. to perform a pilot clinical study, targeting the immune system, for personalised disease prevention. 4. to set up a collaborative data science platform for the studies of early-life factors linked with life-course health.

Keywords: disease risk,early life,exposome,genome,gut microbiome,inflammation,life course health,metabolome
Single-spin magnetic resonance spectroscopy and imaging (ONESPIN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 3498300.0
EU funding (EUR): 3498300.0
Participants: 1
Project status: SIGNED

Magnetic resonance spectroscopy studies matter by probing the resonant frequencies and couplings of paramagnetic nuclei and unpaired electrons. It is a cornerstone of modern science, with numerous applications in condensed-matter physics, materials science, chemistry, biology, and medical imaging. A counterpart is low sensitivity. Conventional spectrometers need large numbers of identical objects to detect a signal. This is an issue for systems with inhomogeneous properties, since their ensemble linewidth is then larger than the linewidth of the individual objects, which limits spectral resolution. The vision of ONESPIN is to apply magnetic resonance spectroscopy to individual objects, based on a new method recently developed in my laboratory. We detect individual electronic paramagnetic centers at 10mK by counting the fluorescence microwave photon emitted when they relax radiatively to the ground state, using a single-microwave-photon detector based on a superconducting qubit. The first project objective is to apply this fluorescence detection method to a large variety of individual paramagnetic centers (organic radicals, transition-metal-ion-containing molecules, enzymes, catalytic centers), which will yield the first single-center-resolved spectra on these systems. The second objective is high-resolution spectroscopy and imaging of the nuclear spins surrounding an individual paramagnetic center by combining hyperfine spectroscopy with fluorescence detection. We will obtain the first magnetic resonance images of individual molecules with single-nuclear-spin resolution, a long-standing dream of magnetic resonance. The third objective is magnetic resonance imaging with 10nm resolution of individual paramagnetic centers in a micron-scale sample by combining magnetic gradients with fluorescence detectionWe will develop new methodologies for single electron- and nuclear-spin magnetic resonance spectroscopy, using microwave photon counting at millikelvin temperatures.
Safe and Efficient Marine Transportation of Liquid Hydrogen (LH2CRAFT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Greece,Korea, Republic of,Belgium,France,United Kingdom,Germany,Spain,Netherlands,Italy
Call: Development of large scale LH2 containment for shipping (HORIZON-JTI-CLEANH2-2022-2, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 5627595.94
EU funding (EUR): 5627595.94
Participants: 14
Project status: SIGNED

The overall goal of LH2CRAFT is to develop next generation, sustainable, commercially attractive, and safe long-term storage and long-distance transportation of Liquid Hydrogen (LH2) for commercial vessels (or even as fuel in certain applications). It aims at developing an innovative containment system of membrane-type for high-capacity storage (e.g., 200,000 m3) at a temperature of -253 deg C and demonstrating and validating it on a 10 ton (180 m3) prototype. It foresees the analysis of alternative conceptual designs with safety and risk assessment initiated at an early stage of the design process of the cargo containment system (CCS) exceeding currently demonstrated sizes. The design will allow LH2 storage to large dimensions, similar to those of existing LNG carriers. Special characteristics (storage tank, handling, distribution, safety, and monitoring subsystems (HDMSS) of the concepts that support up- or down-scaling will be detailed in order to prove the modularity and scalability of the proposed solution. The CCS will achieve AiP and general approval by a major classification society (three IACS members are participating). Demonstration will be done via the detailed design, construction, and testing of the reduced size prototype. LH2CRAFT will also develop a preliminary integrated ship design and carry out the corresponding cost estimation, achieving reduced boil-off rates of 0.5 % per day. A life cycle model will provide a significant tool enabling comparison between different new design or retrofit strategies while the LCA of the large carrier will evaluate the environmental impact from cradle to grave identifying also activities related to sustainability and recyclability and determining the environmental benefits. Two societal objectives will be served: society’s needs and EU’s strong global maritime leadership for its innovation-driven industry providing highly skilled jobs, efficient technological solutions, and international regulatory standards.

Keywords: multi material design,hydrogen storage,liquid hydrogen,maritime transportation,membrane tanks,cargo containment,ccs,waterborne,zewt,carbon neutral fuels,alternative fuels
The World’s Only Bioprosthetic Auto-regulated Artificial Heart: From Total Artificial Heart (TAH) to Physiologic Heart Replacement Therapy (PHRT) (Aeson®)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-10-01
End date: 2025-06-30
Duration (months): 33.0
Total project cost (EUR): 11560168.75
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

At Carmat we have designed and developed Aeson®, the world’s most advanced total artificial heart (TAH), aiming to fulfill an unmet medical need by providing a credible therapeutic alternative to heart transplants for people suffering from end-stage biventricular heart failure. Aeson® is an active implantable medical device intended to replace the ventricles of the native heart in patients suffering from advanced heart failure. The device is electro-hydraulically driven with a shape close to that of a human heart. Once the Aeson® is powered, it mimics the action of a normal heart, providing mechanical circulatory support and restoring normal blood flow through the body. Aeson® differs from other existing artificial hearts (or TAH – total artificial hearts) in its unique combination of three features: pulsatility, autoregulation and hemocompatibility. With Aeson®, Carmat is creating a new therapeutic class of “physiologic heart replacement therapy” (PHRT).

Keywords: bridge to transplant btt,destination therapy dt,pulsatility,biventricular assist device,surgery,heart,heart failure,mechanical assist devices,hemocompatibility,bio prosthetic,haematology,total artificial heart,cardiology,biophysics,bioengineering,biomedical engineering
Magnetism in hybrid organic/inorganic van der Waals heterostructures (MagnOIv)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 191918.16
EU funding (EUR): 191918.16
Participants: 1
Project status: SIGNED

Spintronics, technologies which make use of electron spin rather than solely its charge, represent a promising pathway towards new, efficient technologies. Two-dimensional (2D) van der Waals (vdW) materials are promising candidates for these new technologies as they exhibit exotic electronic and magnetic properties, including recently observed ferromagnetism, and they can be combined with other low-dimensional materials in layered heterostructures. Meanwhile, the development of on-surface synthesis (OSS) protocols for organic and metal-organic materials has led to a pool of magnetic materials whose properties can be tuned via careful selection of molecular precursor. This project aims to develop new hybrid organic/inorganic vdW heterostructures to combine the tuneability of organic and metal-organic materials with 2D ferromagnetic vdW materials. This project will develop new OSS protocols for low-dimensional organic and metal-organic materials on 2D inorganic ferromagnets. It will also seek to characterize the interfacial magnetic and electronic properties of the hybrid vdW heterostructures using scanning probe microscopy. These growth protocols and magnetic properties could inform the design of future spintronics technologies.

Keywords: scanning probe microscopy metal organic 2d materials on surface synthesis ferromagnetism spintronics
CENTAUR - COPERNICUS ENHANCED TOOLS FOR ANTICIPATIVE RESPONSE TO CLIMATE CHANGE IN THE EMERGENCY AND SECURITY DOMAIN (CENTAUR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Italy,Spain,United Kingdom,Belgium,Austria,France,Germany
Call: Copernicus Security and Emergency Services evolution (HORIZON-CL4-2021-SPACE-01, 2021)
Start date: 2022-12-01
End date: 2026-03-31
Duration (months): 40.0
Total project cost (EUR): 4913846.25
EU funding (EUR): 4913846.25
Participants: 14
Project status: SIGNED

Within HORIZON-CL4-2021-SPACE-01-43 - Copernicus Security and Emergency Services evolution, the objective of CENTAUR is to respond to societal challenges deriving from Climate Change threats by developing and demonstrating new service components for the Copernicus Emergency Management Service (CEMS) and Copernicus Service in Support to EU External Action service (SEA), aiming to: 1. Improve situational awareness and preparedness around climate change and its impact on complex emergencies and multi-dimensional (security) crises; 2. Anticipate the occurrence and possible knock-on effects of crisis events, in particular those triggered by climatic extremes, thus contributing to resilience and effective adaptation. In the emergency domain, CENTAUR will address the flood-related threats to population, assets and infrastructures in urban areas. In the Security domain, CENTAUR will address water & food insecurity. The two work streams will be connected via a cross-cutting component focusing on exposure and vulnerability to climate change, as well as resilience and societal capacity for managing environmental risks and social conflict. Across work streams, indicators and models will be validated by different methods. CENTAUR will integrate data coming from multiple heterogeneous sources, with a specific focus on those generated by other Copernicus services, and, in particular, those of the Climate Change Service). It will combine these with meteorological data, socio-economic data, and data coming from new sensors (e.g. traditional and social media). Thus, it will enhance current capacities to produce composite risk indexes and to perform multi-criteria analyses in the emergency and security domains.

Keywords: copernicus emergency,copernicus security,urban flood,foodandwater insecurity,weather forecasts,ai,crises indexes,anticipative response,multi criteria analysis
Preventing Alport syndrome with a natural amino acid (RENOTREAT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-10-01
End date: 2026-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Chronic kidney disease (CKD) is a major burden on society, causing significant morbidity and mortality. A typical symptom of CKD is the loss of protein into the urine, also termed proteinuria, which is usually associated with a poor prognosis. In most cases, a defective glomerulus leads to proteinuria, resulting in damage of the neighboring proximal tubular cells due to protein and lipid overload. In RENOTREAT, we aim to treat Alport syndrome with a natural amino acid, that is known to inhibit the tubular protein uptake receptors cubilin and megalin. This amino acid is already available as a safe treatment in humans, but has never been used for kidney disease. Alport syndrome is a rare disease with underestimated prevalence. It is caused by defective collagen fibers due to pathogenic genetic variants in collagen IV genes. The lack of functional collagen fibers leads to a more permeable glomerular basement membrane, resulting in proteinuria with subsequent proximal tubular damage. In our therapeutic strategy, we will induce tubular proteinuria by blocking protein uptake into the proximal tubule, overturning the paradigm that the degree of proteinuria correlates with kidney damage. First, we will test dosing regimens and bioavailability for three different formulations of the amino acid with regard to the induction of a stable tubular proteinuria in wild-type mice. Using a murine model of Alport syndrome, we will then evaluate these treatments for their potential to slow CKD progression and prolong the survival of the mutant mice. In parallel, we will conduct a pilot trial in healthy human volunteers with the already available form of the amino acid to prepare for a future clinical trial in Alport patients. In summary, we will verify the innovation potential of a novel therapeutic approach of managing Alport syndrome and potentially other proteinuric kidney diseases by performing proof-of-concept preclinical and clinical trials.
Harmonised L ife C ycle A ssessment methods for sustainable and circular BIO based systems (LCA4BIO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Spain,Denmark,Luxembourg,France,Norway,Bulgaria,Portugal
Call: Environmental sustainability and circularity criteria for industrial bio-based systems (HORIZON-CL6-2023-ZEROPOLLUTION-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 3464061.25
EU funding (EUR): 3464061.25
Participants: 10
Project status: SIGNED

EU’s Climate Target Plan goals are compelling all the economic sectors to drastically reduce GHG emissions. As a result, a global shift from fossil-based feedstocks and processes to bio-based systems is being gradually carried out due to the depletion and significant environmental impacts of fossil resources. To facilitate the green transition of the European industry, a more applicable and realistic environmental assessment of bio-based systems is being demanded as a way to demonstrate the improved performance of bio-based products versus its unsustainable counterparts, and identify the best available technologies, to promote the sustainability of industrial procedures and fulfil the zero-pollution objectives encouraged by the European Commission. In this context, the LCA4BIO project aims at developing and validating a new set of improved, harmonized, precise, reliable and applicable assessment methodologies to properly evaluate environmental impacts and circularity in bio-based systems, that can be applied in certification schemes, thus enabling the international trade of this type of products. Additionally, LCA4BIO will address the development of new prospective life cycle assessment methodologies, considering up-scaling and future scenarios via Integrated Assessment Models with manageable levels of uncertainty, for an accurate comparison between potential environmental impacts of emerging bio-based technologies and current systems in the market. To do that, different stakeholders in the bioeconomy value chain will be involved in a co-creation process that will permit to consider their requirements, and test the adequateness of the methodologies developed by the LCA4BIO partners. The new approaches developed in LCA4BIO are expected to stimulate the growth of the European bio-based sectors that could lead to reduce the GHG emissions and other environmental impacts, and promote circularity processes along the economy and society.

Keywords: bioeconomy,bio based,lifecycle,sustainability,carbon footprint,circularity,methodology,prospective,certification,standardization,harmonization,co creation
CLOsing the loOP on non-invasive brain sTiMulation with deep neural networkS (LOOP-TMS) (LOOP-TMS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-11-01
End date: 2027-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

We aim to develop and validate adaptive closed-loop brain stimulation using advanced real-time electroencephalography-transcranial magnetic stimulation (EEG–TMS) technology guided by probabilistic deep artificial neural networks. TMS is performed routinely worldwide in tens of thousands of healthcare institutions for treating a wide variety of brain disorders. However, current TMS protocols are limited by small therapeutic effect sizes and large portions of non-responders. A significant problem is that one size does not fit all: existing TMS protocols are non-personalized, operate without information of instantaneous brain states, function in an open-loop manner, and lack adaptability. To address this, we have developed brain state-dependent stimulation in the ongoing ERC Synergy project ConnectToBrain. Real-time EEG–TMS has enabled reliable prediction of high- vs. low-excitability brain states and coupling of TMS to a prespecified state. While this is major progress, brain state-dependent stimulation is still open-loop and non-adaptive. The key innovation in our current proposal is implementing truly adaptive closed-loop algorithms that continuously monitor TMS effects and optimize stimulation parameters in real-time to maximize beneficial long-term changes in targeted brain networks. Recent advances in machine learning now make this sophisticated approach possible. This project represents a significant leap beyond ConnectToBrain by creating a user-independent, fully automated, adaptive closed-loop real-time EEG-TMS system ready for further testing in clinical trials. Our technology has breakthrough potential as a paradigm-shifting innovation in non-invasive therapeutic brain stimulation, addressing an urgent societal and medical need for more effective, individualized treatment of brain disorders.