Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SME Program for Energy Efficiency through Delivery and Implementation of EneRgy Audits (SPEEDIER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Spain,Ireland,Italy,Spain,Spain,Ireland,Ireland,Romania,France
Call: Capacity building programmes to support implementation of energy audits (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-06-01
End date: 2021-11-30
Duration (months): 30.0
Total project cost (EUR): 2165126.25
EU funding (EUR): 2165126.25
Participants: 11
Project status: CLOSED

The Energy Efficiency Directive, in its art.8, requires Member States to develop programmes encouraging SMEs to undergo energy audits and implement the recommended energy-saving measures. However uptake of energy audits and implementation of energy conservation measures (ECM) among SMEs has been low to date. The barriers to uptake cited in the literature include lack of in-house expertise; lack of resource (time & money); perception that energy auditing is expensive; inability to act due to lack of control of services in the building they use; lack of willingness from landlords to act; inability to access finance due to the small nature of most projects. The SPEEDIER project will address these barriers by providing a self-financing outsourced energy management service to SMEs. By outsourcing the role of energy manager to SPEEDIER Experts, SMEs can access the expertise needed at the required time, leading to greater uptake of energy audits and implementation of energy efficiency measures. SPEEDIER will target groups of SMEs in 4 EU pilot regions: in Spain we will test a location based approach, engage with SMEs based at a single business park to demonstrate that advantages of clustering SMEs give them better access to the economies of large scale projects; in Ireland and Romania SMEs in the manufacturing and hospitality sectors respectively will be approached to test a sector based approach to service delivery; in Italy, a more general approach of accessing SMEs from any sector via ESCOs will be tested. The project is to be self-financing to remove any financial barriers to energy audit uptake and implementation of ECMs. The mechanism for making this work in practice follows an Energy Performance Contract model where the consultant delivering the support retains a share of the savings as payment for the duration of the contract. This ensures that the Service is also suitable for large enterprises. The project consists of 6 RTDs, 3 SMEs, 1 NGO from 5 Member States

Keywords: energy auditing,training,capacity building,energy management
Transgenerational regulation of glucose metabolism by noncoding RNAs (TransGen RNA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany,Denmark
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2021-12-31
Duration (months): 68.0
Total project cost (EUR): 1344497.5
EU funding (EUR): 930637.5
Participants: 2
Project status: CLOSED

Obesity and T2D affect large populations and cause a decline in life expectancy if untreated. The pandemic proportion of obesity and inaptitude of anti-obesity approaches reflect our limited understanding of its complex environmental and genetic etiology. Genome-wide association studies revealed that disease-associated risk variants are often situated in those 98% of the genome not encoding for proteins. This noncoding genomic space yet does not reflect ‘Junk DNA’ but gives rise to >10,000 noncoding RNAs like microRNAs and long, noncoding RNAs (lncRNAs) that implicated in control of glucose metabolism and energy homeostasis also by the applicant (Kornfeld et al. Nature 2013). LncRNAs were paraphrased as 'Dark matter of the genome' due to their tissue-specific and dynamic expression that contrast their poorly understood role in gene regulation. In the 1st part of this proposal, we ask if lncRNAs regulate glucose metabolism and are involved in the obesity-associated dysregulation of insulin signaling in the liver, the major glucoregulatory organ in mammals. Using RNA-Seq and novel lncRNA prediction algorithms, we observed that obesity alters expression of 28 annotated and 15 hitherto unknown lncRNAs in two mouse models of obesity. To identify lncRNAs causally controlling glucose metabolism, we established a siRNA screening system that allows functional interrogation of >650 lncRNAs. These in vitro findings serve as entry for the generation of lncRNA knockout mice that are metabolically phenotyped. In the 2nd part, we hypothesize that germline ncRNAs could control the transgenerational consequences of paternal obesity as shown for lower organisms. This builds upon unpublished findings from our lab showing that obesity profoundly changes expression of germline ncRNAs. In-vitro fertilization and intergenerational breedings will trace the legacy of paternal obesity across generations and reveal ncRNAs involved in this ‘Lamarckian’ control of glucose metabolism.
Precision micromechanical lever for next-generation cell culture systems (MicroMechCell)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: France
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-15
End date: 2018-09-14
Duration (months): 12.0
Total project cost (EUR): 88750.0
EU funding (EUR): 88750.0
Participants: 1
Project status: CLOSED

Instruments to culture cells under confinement conditions are not yet available in the market, yet there is a clear need to culture cells in conditions that most closely mimic in vivo conditions. In particular, such a tool would allow the study of cells in a mechanical environment that resembles the high pressure inside tumours. Based on studies of the market and our designs, we estimate a yearly market of 25 million euros from academic cancer research labs alone. We will further expand these tools for applications in white blood cell maturation and stem cell differentiation. For this project, we need to hire a researcher capable of designing a high-precision instrument to exert confinement on the cells uniformly without crushing them. The basic design has already been validated, but the current method to exert pressure is unreliable and cannot be commercialized. We do not have the precision instrumentation knowledge in-house to build a better tool and we have been unable to find a suitable candidate in the local market. We propose to find an associate who is enthusiastic about entrepreneurship, has expertise in precision instrumentation and experience in microfluidics and cell culture. We will train this candidate in entrepreneurship from the perspective of a start-up company and encourage them to start their own spin-off company with the instruments they build. At Elvesys, we have already created two successful spin-off companies. With these tools, Elvesys will gain an opening in the market of next-generation cell culture tools. We can then establish ourselves as the preferred partners of academic researchers in providing microfluidic solutions to cell culture problems. We will also position ourselves in a pioneering position to become a key player in a strategic sector. Our long-term strategic goal is to develop tools for medical diagnostics, personalized medicine and organ-on-a-chip technologies.

Keywords: microfluidics,cancer,cell mechanics,instrumentation,entrepreneurship
Rotatory role-playing and role-models to enhance the research integrity culture (Path2Integrity)

Framework: Horizon 2020 — Science with and for Society
Programme: Develop the governance for the advancement of responsible research and innovation by all stakeholders, which is sensitive to society needs and demands and promote an ethics framework for research and innovation
Action type: Coordination and support actions
Countries involved: Germany,Spain,Germany,Germany,Spain,Germany,Poland,Bulgaria,Denmark
Call: Innovative methods for teaching ethics and research integrity (H2020-SwafS-2018-1, 2018)
Start date: 2019-01-01
End date: 2022-06-30
Duration (months): 42.0
Total project cost (EUR): 2497636.25
EU funding (EUR): 2497636.25
Participants: 9
Project status: CLOSED

The Path2Integrity project is a two-component coordination and support action to enhance research integrity culture. Path2Integrity develops and fosters role-models and rotatory role-plays for adolescents. A Path2Integrity campaign on scientific facts about research integrity and role-models, raises awareness on research integrity within secondary schools and universities. Complementary a Path2Integrity handbook of instructions, which contains vivid stories on research integrity and rotatory role-playing as primary dialogical exercise increases students’ ability to reason on the acceptance or rejection of norms in research integrity. Partners from the Consortium have award-winning experience in creating those settings, which allows Path2Integrity to work with already in existence and successful educational practices. Taking into account that different disciplines and different schools of thoughts are involved, the Consortium takes paramount importance, to ensure explicitly that the Path2Integrity handbook and campaign are based on optimal and systematic evidence-based decisions. Therefore, the key concept of the Consortium is the development of practical educational knowledge. The Consortium will train at least 150 disseminators in the consortiums countries and beyond, and additionally foster the campaign (fact sheets, infographics, flyers, posters, brochures) in at least 15 European countries to enable awareness-raising in different educational organizations (schools and universities).

Keywords: innovative learning methods for research integrity
Uncovering the pathway of DNA-induced autophagy and its biological functions in viral central nervous system infection (PathAutoBIO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Pathogens establish a range of strategies to efficiently infect and persist in their hosts. These mechanisms are as varied as pathogens themselves, which poses many difficulties for fighting infections. A deep understanding of host defense mechanisms is thus crucial for developing innovative therapies. Sensing of pathogen-derived nucleic acids is pivotal for induction of host defense. The adaptor molecule STING plays a central role in this defense and coordinate activation of immune responses. Recent studies showed that cytosolic DNA sensing and subsequent STING activation also leads to induction of autophagy, a degradative pathway involved in metabolic recycling and regulation of infections and immunity. Both STING and autophagy are involved in a range of diseases e.g. infectious and autoimmune diseases, neurodegeneration and cancers. However, the links between STING and autophagy and their regulation of the balance between protective responses and harmful inflammation is elusive. Likewise, the roles of STING-mediated autophagy during viral infections is unknown. Using cutting-edge tools e.g. ImageStream X flow cytometry and genome-editing of human stem cells-derived brain cells using CRISPR/Cas9, PathAutoBIO will decipher the pathway of this novel STING function. We will then combine in vitro and in vivo models of central nervous system viral infection to explore STING-mediated autophagy functions at this unique site, where autophagy and STING are important for viral clearance. We will build upon the expertise of the host lab in DNA sensing, take advantage of unique tools developed for the project, and integrate leading international collaborators. Combined with my strong background in infection cell biology, our work will provide insights on the cross-regulations between autophagy and immunity. This will lead to a broader understanding of mechanisms regulating diseases presenting global threats for societies and will help the design of broad-spectrum therapies.

Keywords: dna sensing,autophagy,sting,virus,herpes simplex,central nervous system,neuron,microglia,astrocyte,cellular communication,crispr,human induced pluripotent stem cells,imagestream x
Neural stochasticity and criticality in memory replay (BrownianReactivation)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-11-01
End date: 2021-10-31
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

Memories are not stored in a stable manner in the brain. Instead they undergo an almost constant process of transformation and reorganization from the very moment of their formation. This phenomenon, going under the name of memory consolidation is also at the core of fundamental changes in the nature of the information carried by the neural representations. In fact, the switch from hippocampal-based short-term memories to cortex-based long-term memories also coincides with the transitions from episodic to semantic memories. In this proposal, we aim at investigating the role played in memory consolidation by stochasticity and criticality of neural dynamics. We will develop a quantitative approach to this question by combining statistical analysis of newly recorded data, with mathematical modelling of the cortical-hippocampal interaction. Our hypothesis takes the emergence of long-range correlation as the central mechanism characterizing semantic memory formation. We propose that cortical neural circuits poised at criticality can exploit activity avalanches associated with this state to induce the collective activation of large portions of the brain necessary to reconstruct the complete input statistics. Using a hierarchical neural network trained with an input of random samplings of the episodic representations stored in the hippocampus, we will explore the interaction between the performance of the network and its closeness to a critical state. We will complement this work with an analysis of the presence of criticality in the cortical cell assemblies formed after learning a complex behavioural task. We expect these cell assemblies to show maximal contribution to the propagation of neural avalanches and to present consistent coordination with the hippocampal activity. We intend to integrate these results in a coherent theory of long-term memory formation, explaining the ability to generalize starting from event-based experiences.

Keywords: hippocampus,neocortex,semantic memory,critical systems,machine learning
Personalized intracranial aneurysm rupture prognosis using Simulation-Based 4D Flow MRI and Machine Learning (Sim4DFlow)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Cyprus
Call: Widening Fellowships (H2020-WF-03-2020, 2020)
Start date: 2021-09-01
End date: 2023-12-30
Duration (months): 24.0
Total project cost (EUR): 157941.12
EU funding (EUR): 157941.12
Participants: 1
Project status: SIGNED

Unruptured intracranial aneurysm (UIA) is a severe, relatively common cerebrovascular disorder in the general population. Although such aneurysms are mostly asymptomatic and may not burst, a considerable number of UIA patients remain on a high risk of aneurysm rupture, a serious life-threatening condition. Thus, is crucial to decide the timing and type (clipping, coils, and/or stent, flow diverter) of surgical intervention. However, the optimal management strategy of UIA is still open to clinical debate, with recommendations for elective repair after diagnosis based primarily on the aneurysm size and location. While cardiovascular flow imaging has strong potential to provide the required information for surgical decision-making, currently, flow imaging and assessment is not sufficient to reliably predict rupture and quantitatively assess the risk of haemorrhage. By identifying factors contributing to UIA rupture and by incorporating advanced computational techniques, i.e. 4D flow magnetic resonance imaging (MRI), machine learning (ML) algorithms, and computational fluid dynamics (CFD) models, this project will technologically advance quantification of rupture risk assessment on an UIA patient-specific basis. This project, Sim4DFlow, core technological aim is to develop a novel simulation-based imaging framework that can integrate the advanced computational techniques of 4D flow MRI, ML, and CFD. Subsequently, Sim4DFlow will test and validate the framework prognostic capacity in the laboratory setting against relevant data of UIA patients.

Keywords: intracranial aneurysm,medical imaging,4d flow mri,computational mechanics,fluid dynamics simulation,imaged based modeling,risk prediction,machine learning,prognosis
CLONAL AND CELLULAR HETEROGENEITY OF BREAST CANCER AND ITS DYNAMIC EVOLUTION WITH TREATMENT (CLONCELLBREAST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 2497660.0
EU funding (EUR): 2497660.0
Participants: 1
Project status: CLOSED

CLONAL AND CELLULAR HETEROGENEITY OF BREAST CANCER AND ITS DYNAMIC EVOLUTION WITH TREATMENT Breast cancer remains one of the leading causes of cancer death in women. One of the greatest challenges is that breast cancer is a heterogeneous group of 10 diseases defined by genomic profiling. In addition, each tumor is composed of clones and clonal evolution underpins the successive acquisition of the hallmarks of cancer, including metastasis and resistance to therapy. Furthermore tumors display biologically and clinically relevant cellular heterogeneity: immune system, vasculature, and stroma. This cellular heterogeneity both shapes and is shaped by the malignant compartment and modulates response to therapy. This proposal will use longitudinal studies to unravel the clonal and cellular heterogeneity of breast cancer and its dynamic evolution with treatment. The overall goal is to provide a systems level view of evolving clonal and cellular architectures in space and time along the clinical continuum of breast cancers in the clinic, leading to the discovery of new biological and clinical paradigms which will transform our understanding of the disease. The overall approach is to capture the evolution of clonal and cellular heterogeneity of breast cancers in space and time using unique clinical cohorts where samples (biopsies and blood/plasma) are available spanning the whole disease continuum: early breast cancer surgically treated with curative intent, neo-adjuvant therapy, and matched relapse/metastasis. The 4 aims of the proposal are: 1. Characterization of the clonal and cellular heterogeneity of primary tumours from the 10 genomic driver-based breast cancer subtypes (ICs) 2. Comparative characterization of the clonal and cellular heterogeneity of matched pairs of primary and metastatic cancers 3. Characterization of the clonal and epigenetic evolution across therapy courses 4. Characterization of the immune response across therapy courses

Keywords: breast cancer,tumor heterogeneity,clonal evolution
Understanding the role of impact cratering in Earth's evolution through state-of-the-art geochronology (Crater Chron)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2021-02-28
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

The role of impact cratering in the evolution of Earth’s geosphere and biosphere is greatly underappreciated in the field of modern geoscience. Although years of research on terrestrial impact craters have contributed greatly to our knowledge of impact cratering processes and products, the available geochronological data represents a major and fundamental gap in our knowledge. Of the ca. 190 confirmed impact craters on Earth only ca. 10 % are considered to be accurately and precisely dated. Consequently, the vast majority of terrestrial craters cannot be correlated with each other or with other geological events such as mass extinctions. Here we propose to take timely advantage of recent advances both in our understanding of how the mineral zircon (ZrSiO4) can record the age of an impact event and in the analytical techniques used to determine such U-Pb ages to significantly and efficiently grow our database of accurately and precisely dated terrestrial impact craters. Specifically, this project will focus on craters whose precise formation age may have broad implications for Earth’s history. Among others, these include the Siljan impact crater, Sweden, which has been proposed as a contributing factor to the late Devonian mass extinction event, one of the largest mass extinctions in the Phanerozoic, and the Suavjärvi impact crater, northwest Russia. The latter has a very poorly constrained age of between 2.7 and 2.2 Ga but is likely to be the oldest impact crater on Earth with confirmation of an impact age in this study. This innovative action will couple recent advances in microstructural characterisation of shocked zircon (EBSD analysis and Raman mapping) with cutting-edge U-Pb analytical techniques not previously applied to shocked grains (including high resolution, fully quantitative U-Pb age mapping by SIMS and high precision multiple step leaching CA-ID-TIMS) and establish efficient protocols for future dating of craters on Earth and other planetary bodies.

Keywords: impact cratering,shocked zircon,u pb geochronology,ebsd,sims,scanning ion imaging,multiple step leaching ca id tims,mass extinctions