Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Chemical Engineering Immersive Learning (CHARMING)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Germany,Germany,Germany,Germany,Belgium,Belgium,Belgium,France,Netherlands,Denmark,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2018-11-01
End date: 2022-10-31
Duration (months): 48.0
Total project cost (EUR): 4060227.6
EU funding (EUR): 4060227.6
Participants: 13
Project status: CLOSED

The chemical industry in Europe faces stiff competition as it fights to strengthen its position in the global market place. Europe’s greatest asset is its human capital, but the people working in such a technology-based environment, with the rise of the “smart factories” of Industry 4.0, need to be very well qualified. The situation of yesteryear, where a person could be trained to carry out a job for the whole of his/her career has long since gone; now the situation is one of developing skills and competencies, but then being able to adapt, re-learn and be able to cross sectors and disciplines in a world of work that is dynamic and subject to constant change. Continuous professional development, the stimulation of creative thinking and the motivation of youngsters for science & technology are high on the EU’s agenda. Recent developments in immersive learning technologies are providing exciting new tools for teaching and training programmes, yet they remain underutilised in science & technology education, and nowhere is this more true than in the field of chemistry and chemical engineering. CHARMING, the European Training Network for Chemical Engineering Immersive Learning, takes on this challenge by developing learning strategies, content and prototypes for the application of games and virtual/augmented reality for motivating, teaching and training children, students and employees in chemistry, chemical engineering and chemical operations. The inter-sectorial and interdisciplinary CHARMING ETN consists of leading universities and industry participants and trains 15 ESRs in the areas of innovative chemical engineering, instructional psychology & pedagogy and immersive technology. CHARMING’s success is based on integrating these three areas, in order to provide Europe with its highly trained young experts who are ready to help motivating, training and integrating the next-generation human capital of the European chemical industry and beyond.

Keywords: chemistry and chemical engineering education and training,instructional psychology and pedagogy,immersive learning,interdiscipinarity
English Republican Ideas and Translation Networks in Early Modern Germany, c 1640-1848 (ERITNet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-01
End date: 2026-09-29
Duration (months): 36.0
Total project cost (EUR): 337400.64
EU funding (EUR): 337400.64
Participants: 1
Project status: SIGNED

This project explores the significance of translations for the transmission of seventeenth-century English republican ideas in the German lands before the revolution of 1848-9. German political thinkers at the time looked at the constitutional models of their European neighbours for inspiration as the territories formerly ruled by the Holy Roman emperors struggled against outdated feudal structures and strove for national identity and unity. The project aims to gather a body of material that gives us an insight into the distribution, dissemination and reception of English republican works in Germany in a variety of languages, including English, Latin and French as well as German to understand the way in which ideas travelled between countries in the form of print. Combining the history of ideas and the material history of the book in innovative ways and taking inspiration from translation studies and social network theory, this project will focus on the way works were translated, edited and rewritten for new contexts and audiences - in this case German society from the later seventeenth century to the Vormärz. Employing Peter Burke’s analytical concept of ‘cultural translation’ the figure of the translator will be assigned a key role as both the reader and first recipient of a work as well as an independent agent able to shape the text in a new language for a new purpose. Particular attention will also be paid to the relationship between translators, editors and political circles. Challenging a largely anglocentric and transatlantic historiography, this transnational and multi-lingual project thus aims to establish the intellectual reach and legacy of the first English Revolution of 1640-60 on the European Continent by focusing on the country that from 1701 had developed an ever closer relationship with England through the Succession Act which established the Hanoverian dynasty on the English throne.

Keywords: early modern english republicanism,republican thought,english revolution,civil war,print,early modern germany,1848 9 revolution,constitutionalism,democracy
Mechanisms underlying hepatocellular carcinoma pathogenesis and impact of co-morbidities. (HEP-CAR)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Italy,Germany,France,United Kingdom,United Kingdom,United Kingdom
Call: Understanding common mechanisms of diseases and their relevance in co-morbidities (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 5698310.0
EU funding (EUR): 5698310.0
Participants: 10
Project status: CLOSED

Hepatocellular carcinoma (HCC) is the most common liver malignancy, with an estimated 750,000 new cases and 695,000 deaths per year, rating third in incidence and mortality in the world. Whilst incidence and mortality for other cancers are declining, HCC represents an increasing public health problem in Europe with men having a higher incidence than women. Several liver diseases lead to HCC and become per definition co-morbidities, such as nonalcoholic steatohepatitis (NASH) or hepatitis B and C virus infection. Most patients die within one year of diagnosis and treatment failure reflects the heterogeneous nature of this tumour, highlighting the need to identify common and co-morbidity specific disease pathways for individualized therapy. HEP-CAR will focus on three leading HCC associated co-morbidities, specifically NASH and hepatitis B and C infection. Non-biased genetic and lipidomic screens will define cellular pathways that are deregulated in HCC and the impact of co-morbidities and gender. Next to established patient cohorts, several in vitro and in vivo models are available to evaluate the role of co-morbidities as drivers of host oncogenic pathways and to provide much needed pre-clinical models for mechanistic studies and future drug screening. We will develop new approaches to study the impact of co-morbidities on HCC immunobiology, ranging from state-of-art tissue explant models to novel humanized mouse models. The aim of HEP-CAR is to define host pathways that impact HCC pathogenesis and to assess their role in different co-morbidities and treatment responses. The research and clinical excellence will be combined with the knowledge transfer and communication competence of leading organizations such as the European Association for the Study of the Liver (EASL) and the European Liver Patients Association (ELPA). Thus, HEP-CAR will generate tangible and sustained improvements in the understanding, prevention and management of HCC for all European citizens.

Keywords: hepatocellular carcinoma,co morbidity,personalized therapy,diagnosis,prevention,gender distribution,molecular pathways,inflammation
Coordination for Efficient and Green Urban Mobility (CEGUM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 214158.72
EU funding (EUR): 214158.72
Participants: 1
Project status: CLOSED

Traffic hotspots in Europe are expected to generate over 203 billion Euro of economic cost by 2025. Traffic congestion in cities raises serious concerns on the level of CO2 emissions, fuel consumption and discomfort to drivers due to prolonged travel time and large idle time behind the red lights. Unnecessary acceleration and deceleration towards traffic junctions can also highly contribute to extensive use of fuel, increase in emissions and engine and brake wear. Current traffic signal control approaches are not adequate for tackling the problem because they focus on traffic flow efficiency and disregard the individual drivers’ interests. The aim of this project is to develop a method that does not only coordinate all the traffic signals in an urban network, but also takes the vehicle speeds in to account and effectuates a coordination between the traffic lights and vehicle speeds alike. Such a coordination will make the most of the infrastructure and technological developments for reaching an efficient, eco-friendly, and safe urban mobility. Due to the complexity and stochastic nature of the traffic system, the coordination problem will be addressed by integrating model-based distributed control techniques with reinforcement learning-based algorithms. Comprehensive analysis and benchmarking will be performed to obtain a complete evaluation of the idea and prove its effectiveness in improving urban mobility with respect to different indices like fuel consumption, CO2 emissions and number of stops. Adaptive cruise control systems already installed in a large number of cars in European countries. Automakers are announcing the marketing of autonomous cars in the coming years. Soon European cities should be ready to make the most of these technological developments to provide more efficient, cleaner and safer urban mobility and this project is a strong step towards this direction.

Keywords: traffic signal control,vehicle speed control,distributed model predictive control,reinforcement learning
BIOsens – cutting-edge portable device for precise and rapid analysis of crops (BIOsens)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ukraine
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-04-01
End date: 2019-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Every year, companies involved in agriculture businesses experience significant financial losses because of mycotoxins – invisible and dangerous for human health foodborne toxins, which contaminates 25% of the global supply. Farmers, grain elevator owners, and food processing companies suffer the most from this issue and crave for the solution that will allow them easily, swiftly and accurately detect mycotoxins on-site. Timely detection of mycotoxins will prevent them from unsuccessful trade or border rejections, and will lead to revenue increase. BIOsens provides cutting-edge solution that successfully tackles the problem of agriculture companies by creating an easy-to-use portable device for mycotoxin analysis. The mycotoxins testing market is expected to grow to USD 1.75 billion in 2023, and BIOsens is the first solution on the market which combines the accuracy of laboratory testing and the speed of onsite devices. BIOsens team comprises of experts in Biochemistry, Biotechnology, IT and Business which ensure the high quality of the developed solution and successful market entry. According to Financial Times, company’s CEO Andrii Karpiuk is one of 100 eastern Europe’s emerging technology stars and the team has already won numerous start-up competitions, including Intercontinental Startup Battle in San-Francisco. BIOsens aims for global commercialization to ensure that people all over the world consume safe food. SME Instrument Phase 1 funding will enable the company to validate customer needs, conduct thorough analysis of target markets and validate priority countries for market entry, research regulatory requirement and develop an IRP strategy, validate business model and as a result create an elaborated business plan for the successful commercialization of the device.

Keywords: mycotoxins,aflatoxin,ochratoxin a,deoxinivalenol,zearalenone,food testing,food analysis,food contamination,analysis of crops,toxins,toxins detection,sample preparation,biotechnology
Innovative pump to carry out asbestos level measurements by remote control through IOS/ Android App (PUMP3M2D)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Asbestos is an element seriously harmful to health, causing long-term diseases, especially respiratory ones. Although its use in the EU has been banned since 2005, there are many old buildings likely to contain asbestos and be a source of danger to people, especially building maintenance workers. In addition, asbestos-related diseases result in a huge amount of healthcare costs each year and a comparable number of fatalities to car accidents. WLTS is a French company based in Grenoble with nearly 20 years of experience in the sampling and analysis of asbestos in the air and materials. It is an entity accredited by COFRAC, French accreditation body, and characterized by its rigor and independence. The most significant customers are asbestos removal companies. WLTS has developed PUMP3M2D, a smart pump to measure the level of asbestos in the air, equipped with an electronic card that allows its remote control through iOS / Android Apps. This pump allows an improvement and simplification of the sampling process, avoiding the displacement of the technical staff to the worksites anywhere in the world and their exposure to asbestos. PUMP3M2D will be a disruptive revolution in the market of sampling and will provide a competitive advantage with the competitors, it will allow to carry out the internationalization of the company, achieving a ROI of 3.42 and 19 new employees in 3 years.

Keywords: asbestos,removal,intelligent pump,remote control,android app,sampling,mesothelioma,geo positioning gps,real time measurement,no displacements
100% electric high-power and intelligent propulsion system for new and used boat (Electric Voyage)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: Norway
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-12-01
End date: 2023-02-28
Duration (months): 27.0
Total project cost (EUR): 3304428.75
EU funding (EUR): 2313100.13
Participants: 1
Project status: SIGNED

Small fast boats generate 10-15 times more CO2 than land vehicles over the same distance. In Norway, they produce about the same amount of CO2 as all domestic flights combined. Fossil-fuel boating also harms marine ecosystems and humans working in their vicinity. Abandoning fossil fuels bears obvious environmental and societal benefits. Furthermore, all electric boating can be a sound business choice over the boat lifetime, particularly during intensive use seen by professional boat users in aquaculture and ecotourism sectors. However, today’s boat users who wish to switch to all-electric propulsion face major performance issues. ICEs are more attractive in terms of speed and range, while the electrification of boats is highly cost- and time-intensive. Evoy has developed a breakthrough patented electric propulsion system for boats in the 20-to-40-foot segment, E-G2. It delivers precisely what today’s boating market urgently requires in its quest for more environmentally friendly and technologically superior voyaging. Versus current market leaders, E-G2 offers up to 9.7-times higher system power and 6times higher charging power, maintaining 40-knots over 30 nautical miles and a full system charging in 15min - 1h. Our powerful accompanying software allows boat users to effortlessly digitise their boating data, monitor and adjust key operational parameters remotely and combine their data with key external information via the cloud. Building on our proposed international piloting supervised by leading European boating companies such as AKVA Group, we expect to recoup all previous investment into E-G2 in the second year of commercialisation. We will reach an accumulated income of €88m with a 41x return on equity by 2026. In this period, E-G2 will generate 69 new positions at Evoy and our distributors, save 283k tons of CO2eq and cut the operational costs of our end customers by over €37m.

Keywords: marine electric propulsion,cloud,high performance,electric boating,co2 saving,green marine transport,long range,marine big data,marine electrification
bLadder cAncer URine cEll aNalysis (LAUREN)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: United Kingdom
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-2-2014, 2014)
Start date: 2015-06-01
End date: 2018-07-31
Duration (months): 38.0
Total project cost (EUR): 3135925.0
EU funding (EUR): 3135925.0
Participants: 1
Project status: CLOSED

Bladder cancer is the 4th most common cancer in men and the 7th in women, with 330,000- 380,000 new cases annually worldwide or more than 150,000 in Europe and is one of the most expensive cancers to manage. Bladder cancer incidence is strongly related to age, with the highest incidence rates being in older men and women. Cystoscopy/cystoscopic biopsy remains the current gold standard diagnostic and monitoring tool. This procedure is highly invasive and expensive - costing up to €1200 per test - and has been reported to miss in the region of 25% of all bladder tumours. As an adjunct to cystoscopy, urine cytology is routinely carried out globally but its deficiencies in terms of poor cancer detection (low sensitivity) are well recognised and reported. The overall objective of the LAUREN project is to provide a commercial non-invasive in vitro diagnostic that will significantly reduce the management cost of caring for bladder cancer patients, whilst at the same time improving patient comfort and reducing morbidity associated with current invasive procedures. The specific diagnostic is based on the MCM2 + Immunofluorescence biomarker for bladder cancer cells found in urine.The scope of the project is to complete the final development, validation and regulatory activities required to prepare a novel the new diagnostic for the market. The objectives of the project are to: PO1 Clinically validate the biomarkers including the addition of Immuno Fluorescence PO2 Complete development of and validate a single use cell collection device, PO3 Validate the cell recognition software for regulatory acceptance PO4 Validate the software of an automated slide analysis system. PO5 Prepare a complete evidence package to support obtaining a CE Mark and FDA approval for commercialisation

Keywords: bladder cancer cells,improving patient comfort,reducing morbidity,validation of an mcm2 immunofluorescence biomarker,low cost disposable cell collection device
Variational Metadynamics (VARMET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2016-01-01
End date: 2020-12-31
Duration (months): 60.0
Total project cost (EUR): 2488827.0
EU funding (EUR): 2488827.0
Participants: 1
Project status: CLOSED

We propose to extend the time scale accessible to atomistic-based simulation methods from the current range to millisecond and beyond without special-purpose machines. We shall do this by combining and extending two recent developments: a recent reformulation of the enhanced sampling problem into a powerful variational principle that opens a wealth of possibilities and provides a novel and fruitful standpoint for new developments; and a procedure for extracting rates from enhanced runs. We shall apply the methods thus developed to two major problems of great practical interest. One is the lifetime of a ligand-protein bound state. This quantity is not easily accessible experimentally and yet it is crucial in drug design to determine the potency of a drug. We plan to develop a viable and widely applicable way to compute it. The other is a study of crystallization from solution, for which we wish to determine the nucleation mechanism and nucleation rates and understand and control crystal growth. These are all issues of great relevance in engineering, pharmacology and nanotechnology. Besides being relevant on their own merits, these two applications present different challenges to the enhanced methods. We also believe that new methods should not be developed in an abstract way but in close interaction with real-life applications.