Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A point-of-care serological rapid diagnostic test for risk of Plasmodium vivax hypnozoite infection (PvSeroRDT) (PvSeroRDT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: France,Senegal,Ethiopia,Madagascar,United Kingdom,Switzerland,Australia
Call: Advancing point-of-care diagnostics to the market (HORIZON-JU-GH-EDCTP3-2023-02-two-stage, 2023)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 4062396.23
EU funding (EUR): 4062396.23
Participants: 8
Project status: SIGNED

Plasmodium vivax is considered the most difficult species of human malaria parasite to eliminate because of the inability of conventional diagnostics to detect individuals who carry dormant liver forms and sustain malaria transmission. The consortium has developed the first diagnostic test that addresses this problem. PvSeroRDT aims to develop a point-of-care (POC) rapid diagnostic test (RDT) to transfer the consortium’s validated lab-based test to the field to support implementation of the P. vivax Serological Test and Treatment (PvSeroTAT) malaria control strategy. The PvSeroRDT specific objectives are: 1) Develop a POC RDT using lateral flow technology to measure antibodies to four P. vivax proteins that are biomarkers for the dormant liver-stage of P. vivax. 2) Establish Africa-based manufacturing capacity at DIATROPIX (Senegal) following RDT development at Abingdon Health, a UK-based SME specialising in lateral flow assays. 3) Validate RDT performance with bio-banked samples, followed by field-based clinical validation on freshly collected samples in Ethiopia and Madagascar. 4) Develop a clear regulatory strategy to streamline market authorization and access to this first-in-class P. vivax serological testing. PvSeroRDT addresses all expected outcomes and impacts of this call topic and work program, respectively. Specifically, it will contribute a robust POC diagnostic to the pipeline in sub-Saharan Africa (SSA) and enable the implementation of the AU-EU Innovation Agenda for public health. The project is designed to address the WHO’s preferred profile for P. vivax diagnosis, to translate an SME prototype to Africa-based industrial design, and to test clinical performance in several SSA sites, thus enhancing international cooperation in SSA and improving training opportunities in SSA. Ultimately, PvSeroRDT will facilitate implementation of PvSeroTAT – a new intervention for malaria elimination.

Keywords: malaria,serology,p vivax,senegal,ethiopia,madagascar,primaquine
In Vitro Reconstitution of the Minimal Eukaryotic Cell Cycle Oscillator (CellCycleInVitro)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Cell growth and division are the basis of all forms of life. In eukaryotes, the clock-like cycles of genome duplication and cell division are orchestrated by a complex set of biochemical reactions. Theory suggests that a negative feedback loop regulating the cyclin-dependent kinase 1 generates the cell cycle oscillations; however, because the putative cell cycle ‘clock’ is tightly interlinked with numerous other biological networks, experimental validation has proven to be a challenge. To date, several questions key to understanding how cell cycle oscillations arise remain unanswered: Do the identified core components indeed give rise to oscillations? Which components are necessary and sufficient? And what makes the cell cycle clock oscillate with varying frequency? To unravel what makes the cell cycle ‘tick’, we will reconstitute the core cell cycle oscillator in vitro. Specifically, combining state-of-the-art biochemistry, including the powerful frog egg extract system, with synthetic and computational biology, we will (1) develop fluorescent-based sensors to monitor key enzymatic activities of the cell cycle oscillator, (2) use computational models to identify operational conditions for the reconstitution of the oscillator, (3) reconstitute and analyse the individual reactions of the predicted negative feedback loop, and (4) assemble the complete cell cycle oscillator in vitro and establish its capacity to oscillate, the set of necessary components, and which elements of the oscillator define its frequency. Using in vitro reconstitution as a radically new approach to interrogating the cell cycle, CellCycleInVitro will answer longstanding questions about the cell cycle clock. But more than this, in developing a novel in vitro experimental platform and biosensors for the study of cell division, we will provide powerful new tools with applications ranging from synthetic biology to the development of new therapeutics targeting uncontrolled cell proliferation.

Keywords: cell cycle,biological oscillator,in vitro reconstitution,computational modelling
Copying As Common Practice in Early Modern Architecture (CCPEMA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2029-01-31
Duration (months): 69.0
Total project cost (EUR): 1489668.0
EU funding (EUR): 1489668.0
Participants: 1
Project status: SIGNED

This project advances the hypothesis that techniques of mechanical drawing, and specifically, drawings produced by manual copying and direct tracing, served as the bedrock of early modern architectural education prior to the advent of formal schools of architecture. The normative histories of fifteenth- and sixteenth-century Italian architecture have relegated drawings of mechanical subject matter (construction machinery, scaffolding systems, structural diagrams, military devices) to a lower, non-artistic status. These drawings are deemed inferior not only due to their subject matter, but also due to their ubiquity; the mechanical drawings used by early modern architects were widely circulated and routinely copied. Indeed, copying drawings and traces have long been considered corrupt. In the foundational discussions of disegno (the practice and product of drawing), Giorgio Vasari explicitly ridiculed copying practices, and the “infinite” number of substandard artists who employ techniques of tracing. In turn, he celebrated drawings that were demonstratively autograph or individual as the embodiment of their creator’s singular “genius.” This framework lay the foundation for modern history’s critical assessment of drawings and cemented the idealization of early modern Italy’s “great” architects. While recent decades have seen a notable increase in research on techniques of copying and tracing in the study of early modern painting, there remains a critical absence of scholarship that examines the derivative practices that underscored early modern architecture. Looking beyond anachronistic conceptions of “art,” “architecture,” and “engineering” and examining a broader corpus of early modern architectural drawings. Identifying images that are formally and technically related in their execution, the project investigates the intellectual processes of design training and brings to light the collaborative frameworks of architectural production.

Keywords: architectural history,history of science and technology,technical art history
CONNECTing the dots withIN diGItal HEALTH Innovation Ecosystems (CONNECTINGHEALTH)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Ireland,Hungary,Finland,France,Spain,United Kingdom
Call: Preparatory action for setting up joint programmes among innovation ecosystems actors (HORIZON-EIE-2021-CONNECT-01, 2021)
Start date: 2022-06-15
End date: 2024-06-14
Duration (months): 24.0
Total project cost (EUR): 409376.0
EU funding (EUR): 409376.0
Participants: 6
Project status: CLOSED

"CONNECTINGHEALTH - CONNECTing the dots withIN diGItal HEALTH Innovation Ecosystems" is a two-year preparatory action for setting up joint programme among the actors of the digital health ecosystems in Europe and beyond. The overall aim of the project is fully aligned with the call for proposals, which is to foster interconnected, inclusive innovation ecosystems across Europe and maximising the value of innovation in one of the sectors that provides the future opportunities for growth and increased competitiveness and innovativeness, namely the digital health. CONNECTINGHEALTH will be implemented by the small and agile core group, which consists of the European Connected Health Alliance as a European partner and three organisations that are leaders of the digital health ecosystems in their regions: Scotland, Western Hungary and Southern Ostrobothnia. To reach its goals, CONNECTINGHEALTH will conduct the mapping of the digital health ecosystems in Europe, their initiatives, projects, resources and stakeholders, develop the future scenario for the digital health sector in Europe 2030 and identify the preferable future that will be the base for the multi-year action plan, co-designed together with the stakeholders and ecosystems engaged in the project through the futures and investigative workshops. Besides the investigation on the general level of the digital health, the project will look deeper into the three topic crucial for the further development of the digital health sector in Europe, namely: 1/ health for wealth opportunities, 2/ opportunities of the transition from traditional to digital health industry and 3/ opportunities of engaging the stakeholders from health and social sector in the development and implementation of the solutions. CONNECTINGHEALTH will result with the multi-year action plan and the number of immediately exploitable results, eg. the future scenarios and the focus area papers. They will be disseminated widely to the key stakeholders.

Keywords: digital health,innovation ecosystems,thematic innovation ecosystems,growth and competitiveness,health for wealth
A Biomarker-Based Platform for Early Diagnosis of Chronic Liver Disease to Enable Personalized Therapy (LIVERAIM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Innovative Health Initiative
Action type: Research and Innovation actions
Partnership: IHI (JU-JTI)
Countries involved: Spain,Belgium,Italy,Denmark,Germany,France,Switzerland,United States,United Kingdom,Croatia,Slovakia,Sweden,Ireland
Call: Screening platform and biomarkers for prediction and prevention of diseases of unmet public health need (HORIZON-JU-IHI-2022-03-single-stage, 2022)
Start date: 2024-03-01
End date: 2030-02-28
Duration (months): 72.0
Total project cost (EUR): 25053616.39
EU funding (EUR): 13854592.75
Participants: 32
Project status: SIGNED

Liver cirrhosis and liver cancer are common and responsible for high morbidity, impaired quality of life, major costs for healthcare systems, causing 300K deaths per year in Europe. Predominant etiological factors are obesity, type2 diabetes, and increased alcohol in-take, which are all on the rise. It is predicted that healthy life expectancy will decrease in Europe over the next 30 years because of deaths due to liver disease. Liver cirrhosis develops after a very long period of asymptomatic liver fibrosis, staying undetected until patients develop severe complications due to cirrhosis or liver cancer. Currently the only effective treatment available is liver transplantation which is not applicable to all patients. If fibrosis is detected early, to target the course of liver disease, then liver fibrosis is reversible. The LIVERAIM project concentrates a team of renowned clinical centres and Industrial partners, including SMEs, with great expertise in the field of Liver Disease, the aim being to design and validate a screening platform with biomarkers for population screening to use across Europe. The objective is to identify liver disease early and apply personalized therapeutic interventions. A large number of existing biomarkers will be tested for fibrosis prediction accuracy using biobank plasma samples from 40,000 subjects from previous H2020 EU-funded cohorts. LIVERAIM will develop a screening platform with biomarkers using AI for personalized early diagnosis of fibrosis to be validated in a RCT of 100K subjects from 6 representative EU countries. The platform will be linked to tailored, personalized therapeutic interventions to halt fibrosis progression. With LIVERAIM, early diagnosis and personalized intervention can stop liver disease progression, help decrease morbidity and mortality and the associated societal burdens both economic and health inequity.

Keywords: liver disease,cirrhosis,liver cancer,fibrosis,screening methodology,biomarkers,transient elastography,validation,risk factor stratification,cost effectiveness analysis,implementation strategy
Chemometric histopathology via coherent Raman imaging for precision medicine (CHARM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Challenges
Action type: EIC actions
Countries involved: Italy,Germany,United Kingdom,Spain
Call: Medical Technology and Devices: from Lab to Patient (HORIZON-EIC-2021-TRANSITION-CHALLENGES-01, 2021)
Start date: 2022-05-01
End date: 2025-10-31
Duration (months): 42.0
Total project cost (EUR): 2441980.0
EU funding (EUR): 2441979.0
Participants: 7
Project status: SIGNED

The CHARM project aims to radically transform the cancer diagnosing process and bring the emerging field of digital histopathology to the next level, introducing a novel technology for tissue analysis, capable to measure the molecular composition of the patient tissue samples and to recognize and classify the tumor in a completely label/stain-free way. The instrument, integrated with artificial intelligence (AI), will offer to histopathologists a reliable, fast and low-cost Clinical Decision Support System (CDSS) for cancer diagnosis and personalized cancer therapy. We will develop a Class C, (IVDR, In-Vitro Diagnostic Regulation) medical device consisting of a turnkey low-cost broadband Coherent Raman Scattering (CRS) microscope (enabled by our patented graphene-based fiber laser technology), named the Chemometric Pathology System (CPS), integrating an AI module based on deep learning, statistics and machine learning. The CPS will be capable of automatically analyzing unstained tissues, providing fast and accurate tumour identification (differentiating normal vs neoplastic tissues) with accuracy >98% and final tumour diagnosis prediction (differentiating and grading histologic subtypes) with accuracy >90%, thus offering to the histopathologist a decision tree compatible with existing clinical protocols but with biomolecular-based objectivity and reduced time to result (TRL6). We will develop a robust business case for the application and ensure the project continuation to higher TRLs and the final market entrance. This proposal builds on the results of the ERC POC project GSYNCOR.

Keywords: coherent raman spectroscopy,graphene based fiber lasers,digital histopathology,head and neck tumor
Seeing Stuff: Perceiving Materials and their Properties (STUFF)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2499711.0
EU funding (EUR): 2499711.0
Participants: 1
Project status: SIGNED

Different materials, such as silk, soil, steel and soap exhibit an astonishing variety of physical properties, appearances and behaviours. The material properties of objects and substances are central to practically every task we perform, from selecting and preparing food, to detecting slippery ground, to using tools effectively. Without touching a surface, we usually enjoy a vivid impression of what it would feel like, through the sense of sight. Yet, how we do so remains mysterious. Decades of research has focussed on the visual recognition of objects, faces and scenes. By comparison, how we see, think about and interact with ‘stuff’ has been relatively neglected. STUFF addresses this major gap in our understanding. Material perception poses unique and fascinating challenges. The image of a surface is a complex and ambiguous combination of lighting, shape, and material properties. How does the visual system disentangle these intermingled physical factors? Deformable materials like liquids and textiles move and change shape in complex yet lawful ways. How do we infer intrinsic properties like viscosity, compliance and elasticity from such ever-changing stimuli? And how do we reason about and predict their future behaviours as they interact with their surroundings? How do we adapt our own interactions with objects to take into consideration their hardness, density, friction and other physical characteristics, allowing us to pluck a raspberry without crushing it, or pick up wet soap without it slipping through our fingers? STUFF takes a radically interdisciplinary approach to these questions in five tightly interconnected work-packages, bringing together state-of-the-art methods from experimental psychology and behavioural neuroscience, computer graphics and computational image analysis, machine learning and even art. We draw on real and simulated materials, to uncover how we perceive, reason about, predict and interact with materials and their properties.

Keywords: visual perception,material perception,art perception,surfaces,objects,shape,computational modelling,grasping,action,deep learning
Enabling interoperability of multi-vendor HVDC grids (InterOPERA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: France,Germany,Sweden,Belgium,Denmark,Netherlands,Norway,Italy,United Kingdom,Japan
Call: Real Time Demonstrator of Multi-Vendor Multi-Terminal VSC-HVDC with Grid Forming Capability (in support of the offshore strategy) (HORIZON-CL5-2022-D3-01, 2022)
Start date: 2023-01-01
End date: 2027-04-30
Duration (months): 52.0
Total project cost (EUR): 70001290.48
EU funding (EUR): 50720449.35
Participants: 33
Project status: SIGNED

To unlock multi-vendor HVDC grids and foster the transition of the European energy sector at large scale, InterOPERA proposes a coordinated approach between a diverse, high-level group of industries at the forefront of RES development and grid management. 4 HVDC vendors, 8 TSOs, 2 wind turbine vendors and 3 wind park developers bring their industrial knowledge and practical abilities to make future HVDC systems mutually compatible and interoperable by design, and to improve the grid forming capabilities of offshore and onshore converters. Foreseen and planned HVDC projects will be analysed to define a demonstrator case study. The resulting system-level design will be usable as a guidance to coordinate offshore network planning. This new way of framing the European grid architecture and topology will ensure forward compatibility for future seamless system expansion. Interoperability of control and protection systems will be de-risked through the execution of all necessary activities concurring to the implementation of a real-time physical demonstrator. Concrete results will be delivered through this practical work: detailed functional specifications for each subsystem, standardised models, simulation platforms and interaction study processes, multi-vendor cooperation agreements. Those frameworks will be generalised into operational and strategic tools available to all European stakeholders for the development of multi-terminal HVDC grids that will enhance offshore wind development and integration. Solutions for multi-vendor project procurement, compliant with existing and future regulations, standards and laws, integrating the technical specifications and interoperability assessment tender stages, will be provided to pave the way to the first real-life projects in Europe. External stakeholders will be involved in two-way consultation workshops to maximise the uptake of InterOPERA’s key exploitable results. Recommendations to grid codes and standards will be issued.

Keywords: interoperability,hvdc,multi terminal,multi vendor,wind farm,real time simulation,grid forming,offshore,control and protection systems
Two-photon miniaturized integrated neuro-optical photon system for neuronal circuits investigaiton in freely moving primates (2P-MINOPS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-10-01
End date: 2027-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The revolution in optogenetics began with the discovery of light-sensitive microbial opsins and their use to control neuronal activity with cell-type specificity, allowing for the first time functional mapping of the brain with cell type specificity. However, the wide-field illumination traditionally used in optogenetics synchronously activates large populations of neurons, lacking the precision needed to reproduce the complex, natural firing patterns of neural circuits. To overcome this limitation, Emiliani’s lab developed “circuit optogenetics,” combining computer-generated holography, temporal focusing, and two-photon excitation to achieve optogenetic control of circuits with millisecond-scale spatiotemporal precision, targeting single cells in depth. These methods have enabled unprecedentedly precise mapping and manipulation of neuronal circuits in mice, both head-fixed and freely moving. Building on advances from the HOLOVIS project—notably increased targeting capacity with ultra-fast sequential holographic targeting (FLiT), deeper brain layer access with three-photon (3P) holography, and performing circuit optogenetics in freely moving mice using two-photon holographic endoscopy—the current goal is to extend this precision to non-human primates. The project aims to develop 2P-MINOPS, an integrated and miniaturized two-photon system leveraging recent advances in miniaturized sources, modulators, and detectors. This platform will enable wireless optical study and manipulation of brain circuits in freely moving primates, paving the way for novel research into complex brain functions in models closer to humans.