Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Targeted Antigen deLivery to Langerin: molecular basis of recognition and its implication in antigen uptake, processing and presentation to T cells (TALL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria,Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2023-06-30
Duration (months): 34.0
Total project cost (EUR): 244209.77
EU funding (EUR): 244209.6
Participants: 2
Project status: SIGNED

The skin is an attractive target in human vaccination harboring a dense network of immune cells. For instance, Lagerhans cells (LCs) are specialized in the identification of antigens derived from pathogens, and their subsequent internalization and presentation to induce a T cell response. The aim of the present proposal is to establish a novel mechanism for antigen delivery, targeted specifically to a particular receptor of LCs, Langerin, capable of triggering a T cell response. To this end, the vaccine scaffold will be composed of a T cell stimulating peptide covalently linked to a glycomimetic probe aiming exclusively to Langerin. This project gathers the use of several techniques derived from both chemistry and biology at the disposal of immunology. First, molecular docking of the binding groove in complex with the antigenic peptide will be crucial to rationally design the vaccine scaffold. Once chosen, the most suitable candidate will be synthetized and analyzed by a combination of different Nuclear Magnetic Resonance (NMR) techniques. Elucidation of the antigen-Langerin affinity using NMR experiments will be critical to choose the most specific antigen to be further employed in biological tests. Antigen uptake will be monitored by flow cytometry and confocal imaging. Whole skin cell suspensions will be then employed to test the specificity of the construct. Finally, antigenic peptides will be tested for T cell activation and proliferation. The translational outcome of this research will be applied in the design of transdermal patches, which represent an attractive approach to intramuscular vaccination, allowing targeted and pain-free delivery with minimal invasiveness.

Keywords: langerin,molecular recognition,peptide chemistry,carbohydrates
planned relocatIon as adapTation in a cHAnging ClimAte (ITHACA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-05-01
End date: 2024-10-16
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: SIGNED

As climate change impacts intensify, the number of people moving both within and across borders is likely to increase. Whilst research has focused on individual- or household-level migration, much less is understood about planned relocation (PR) - a government-led strategy in which a community is resettled to another location within the country to avoid climate risk. PR in Europe remains largely framed as an ad hoc response in post-disaster settings. Yet, as climate change is projected to increase coastal and river flood risk, governments will be required to shift from supporting emergency solutions to managing strategic approaches to protect their citizens. My project aims at uncovering and theorising the distinct institutional and governance challenges in the anticipatory and strategic employment of PR in a changing climate. By focusing on the interface between traditional approaches to PR and transformational adaptation strategies, I will identify how the current PR and climate adaptation policy and governance landscapes should be innovated to integrate PR into long-term resilient development in Europe. I will employ a ‘Comparative Case Study’ approach to study the emerging policy and practice of PR as adaptation in the Po river basin (IT) and identify enablers and constraints for transformational change. I will rely on a three-pronged data collection strategy consisting of historical analysis, content analysis and interviews with stakeholders at the basin, national and international levels. Based on the literature on transformational adaptation and the evidence from the Italian case study, I will develop a conceptual framework for governing climate-induced PR, which will be tested and refined in the shadow case of government-led relocation in the Austrian upper Danube. The project seeks to energise academic attention on PR as a form of human mobility in the context of climate change, and stimulate discussion around its strategic employment in Europe.

Keywords: climate change adaptation,disaster risk reduction,loss and damage,human mobility,governance
Pooling SME adoption and deployment of Blockchain and other DLTs (BLOCKPOOL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany,Spain,Germany,Cyprus,Belgium,Greece,France
Call: Blockchain and distributed ledger technologies for SMEs (H2020-INNOSUP-2018-03, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 1495175.0
EU funding (EUR): 1495175.0
Participants: 7
Project status: SIGNED

Blockchain and Distributed Ledger Technologies (BDLTs) cover a revolutionary potential but their uptake and deployment to value chains other than financial ones remains slow. Among other causes, fragmentation and a series of obstacles to their market deployment hamper the diffusion and pace of adoption of BDLTs by SMEs. Blockpool.eu (https://blockpool.eu/) aims to enhance SME innovation capacity by providing better innovation support. We will use the power of intermediary organisations (clusters, federations...) and cross-regional industrial networks to Pilot the acceleration of SME uptake and deployment of BDLTs. Our consortium thus aims to accelerate the cross-border uptake and deployment of BDLTs by/to European SMEs. Blockpool.eu aims to grow beyond the Pilot Project to become a sustainable Portal for BDLT deployment. We will build and strengthen SMEs’ and intermediaries’ BDLT capacity in a cross-value chain fashion, and strengthening both supply and demand sides through 1) a Blockchain “deployment pool” and 2) generic support activities. Besides enabling actions toward framework conditions and the capacity increase of SMEs, intermediaries and to another extent policy makers and regulators, Blockpool.eu will develop a Deployment Pool: 25 SME projects will be selected through an Open Call allocating at least 50% of the total project budget to test and validate new BDLT solutions (TRL7+) in most prominent sectors (e.g. supply chain, energy, healthcare, Fintech, Insurance, Legal, Shipping & Social Good). SMEs will also benefit from the support of our Mentors Network, training (MOOC/Webinars), as well as other innovative tools. That way, Blockpool.eu will contribute to the demonstration of BDLTs to SMEs across EU value chains but also generate impacts at a broader level than the one of its Deployment Pool: we will generate impacts at the level of the framework conditions (economic, social, legal and regulatory) conditioning the uptake and deployment of BDLTs.

Keywords: blockchain,cryptocurrency,cryptographic hash,distributed ledger,mining,value chain,smes,intermediaries,clusters,networks
Functional and Molecular Analyses of the Interplay between Hematopoietic and Mesenchymal Niche Cells in Human Myelodysplastic Syndromes. (HemNichMDS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-08-01
End date: 2022-01-31
Duration (months): 78.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Myelodysplastic syndromes (MDS) are heterogeneous clonal hematopoietic stem cell diseases mainly affecting the elderly (45/100,000 in >70 years). The prevalence of MDS is expected to rise mainly as a result of an aging population. MDS is characterized by ineffective production of mature blood cells with peripheral cytopenias and the propensity to evolve to acute myeloid leukemia. Most MDS patients rely on continuous blood transfusions resulting in significant costs to healthcare systems and, most importantly, secondary effects leading to complications and patient deaths. The only potential curative treatment for MDS is hematopoietic stem cells (HSC) transplantation, which is limited to younger patients with suitable donors (<10% of MDS patients). Increasing evidence indicates that myeloid neoplasms can be triggered by abnormal functional properties of the bone marrow microenvironment in mice. However, it remains to be seen whether this also applies to human hematopoietic neoplasms. Our work revealed that patient-derived mesenchymal niche cells are essential to propagate human MDS HSCs in vivo, thus highlighting the crucial role of the niche in human MDS. Moreover, our data indicate that human MDS hematopoietic cells may “educate” their niche environment into a self-reinforcing one. The goal of our proposal is to decipher the interplay between hematopoietic and mesenchymal niche cells in human MDS, and to assess innovative means by which we could target diseased cells to improve MDS patient outcomes. We will perform a comprehensive molecular characterization of highly purified primary mesenchymal niche cells to define new prognostic/therapeutic niche factors in MDS. More importantly, we will take advantage of our unique xenograft model of MDS to translate our findings into groundbreaking novel therapeutic strategies for MDS patients, by disrupting essential niche/MDS stem cell interactions.

Keywords: myelodysplastic syndromes,leukemia,bone marrow niche,mesenchymal cells,epigenetic,xenografts,mouse models,stem cell,drug target,therapy
M4ShaleGas: Measuring, monitoring, mitigating managing the environmental impact of shale gas (M4ShaleGas)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Poland,Norway,Poland,Poland,France,Czechia,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Denmark,Portugal
Call: Understanding, preventing and mitigating the potential environmental impacts and risks of shale gas exploration and exploitation (H2020-LCE-2014-1, 2014)
Start date: 2015-06-01
End date: 2017-11-30
Duration (months): 30.0
Total project cost (EUR): 2999648.75
EU funding (EUR): 2999647.5
Participants: 20
Project status: CLOSED

The accelerated development of shale gas is accompanied by growing public concern regarding the safety of shale gas extraction and its impact on human health and the environment. For the US, shale gas exploitation proved very successful in changing the energy landscape in terms of security of domestic supply and increased contribution of gas in the energy mix. For Europe, shale gas exploitation could increase our resources and production of natural gas; a critical fuel for the transition to a low carbon energy system. However, there are a number of important gaps in our present understanding of shale gas exploration and exploitation, and a strong need for independent, science-based knowledge of its potential impacts in a European context. The M4ShaleGas program focuses on reviewing and improving existing best practices and innovative technologies for measuring, monitoring, mitigating and managing the environmental impact of shale gas exploration and exploitation in Europe. The technical and social research activities will yield integrated scientific recommendations for 1) how to minimize environmental risks to the subsurface, surface and atmosphere, 2) propose risk reduction and mitigation measures and 3) how to address the public attitude towards shale gas development. The 18 research institutes from 10 European Union Member States that collaborate in the M4ShaleGas consortium cover different geopolitical regions in Europe, including Member States that are at the forefront regarding shale gas exploration and exploitation in Europe as well as Member States where shale gas exploitation is not yet being actively pursued. The project governance ensures proper integration of all research activities. Knowledge and experience on best practices is imbedded by direct collaboration with US and Canadian research partners and input from representatives from the industry. During the project, results will be public and actively disseminated to all stakeholders.

Keywords: shale gas,environment,health,safety,best practice,scientific recommendations,europe,public perception,regulation,engagement,hydraulic fracturing,water,emissions,exploration,exploitation
DroneHopper: an innovative solution for firefighting through remote-controlled aircrafts. (DroneHopper)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Drone Hopper is remote-controlled aircraft that incorporates a container unit to hold liquids that can be used for firefighting, propelling nebulised liquid to be directed towards land. In Europe, fires destroy millions of hectares of forest woodlands causing the loss of many human and fauna lives and an immense economic damage. The company has created an innovative technology for wildfire extinguishment thanks to a patented release mechanism that convert the water into small water drops (water mist) and mixes it with the air creating a wet air flow that suffocates the fire by removing the oxygen from the chemical combustion reaction. Apart from the technical novelty, there are several operational and economic benefits that make it a viable commercial proposition to compete widely in the market for fire management with its primary customers being the public administrations responsible, or the subcontracted private companies. In addition to the application of the technology in firefighting, the systems are perfectly adaptable to discharge other types of liquid, such as fertilizers and fumigation for agricultural management. The main focus of the feasibility study is to identify the initial high-potential target European markets to trial and launch the service in the first 3 years of commercialization, as well as to assess in more detail the international competitive landscape and identify market risks to determine opportunities and threats. The next step would be to devise a marketing and sales strategy. Forest fires are the most important threat to forest and wooded area in Southern Europe. Our project will face the European challenges proposed by Legislation on protecting the EU's forests against fire. Investments in firefighting and fire prevention is essential. Europe is has supported forest fire research since the late 1980s with the aim of strengthening research activities and initiatives such as Drone Hopper.

Keywords: wildfire,drones,forest,firefighting
Establishing services enhancing the innovation management capacity of SME's in the Enterprise Europe Network (ICEKAM-2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Iceland
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 19856.25
EU funding (EUR): 19856.0
Participants: 1
Project status: CLOSED

Main task is to establish the services “Enhancing the innovation management capacity of SMEs” within the Enterprise Europe Network with the intention to enhance SME’s potential in a successful result of their participation in The SME instruments project and to assist particularly promising SMEs in enhancing their innovation management capacities. The services are aimed at SMEs in Iceland with a great potential for international growth, but lack knowledge, skills or ability to manage innovation activities. Highly qualified staff of Enterprise Europe Network at the Innovation Center Iceland possesses the skills required and in-depth knowledge of the support required to enable companies to reach their potential.

Keywords: sme instruments,key account management,innovation analysis,innovation management,innovation gap analysis
CROWD sensing and ride sharing FOR ROAD Sustainability (CROWD4ROADS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Italy,Italy,Romania,France,United Kingdom,United Kingdom,United Kingdom
Call: Collective Awareness Platforms for Sustainability and Social Innovation (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2019-03-31
Duration (months): 39.0
Total project cost (EUR): 1543867.51
EU funding (EUR): 1543866.76
Participants: 10
Project status: CLOSED

Road networks are the largest publicly owned assets and they play a fundamental role in socio-economic development and competitiveness. At the same time, roads have huge environmental impacts and maintenance costs. Passenger cars account for 73.7% of total intra-EU passenger transport, with an average car occupancy rate well below 2 passengers per car. The resulting traffic accounts for about 12% of CO2 emissions. Delayed maintenance impairs road safety and increases cost of intervention, vehicle operating costs, and emissions. The CROWD4ROADS project combines trip sharing and crowd sensing initiatives to harness collective intelligence to contribute to the solution of the sustainability issues of road passenger transport, by increasing the car occupancy rate and by engaging drivers and passengers in road monitoring. BlaBlaCar (http://blablacar.com/) is the largest trusted ride sharing community worldwide, with more than 10.000.000 members in 14 countries, while SmartRoadSense (http://smartroadsense.it/) is a crowd sensing system which makes use of the accelerometers of car-mounted smartphones to estimate the roughness of the road surface. The CROWD4ROADS platform establishes a synergistic relationship between BlaBlaCar and SmartRoadSense, exploiting the network effect which is inherent in both the initiatives, to provide a sizeable impact in terms of car occupancy rate, road monitoring, and end-user engagement in road maintenance and transport sustainability. Scalability issues will be addressed during the project both from a technical and from a social point of view. The approach will be validated on representative large scale pilots, involving more than 1 million people and covering more than 1 million km of roads. Impacts will be measures in terms of road coverage, car occupancy rates, and open data volume.

Keywords: crowd sensing,trip sharing,road monitoring,car occupancy rate
Targeting infertility associated to defective Insulin/IGF-1 signalling (INFISS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-05-01
End date: 2018-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Fertility decline is the largest contributor to population ageing in the world today, and infertility negatively impacts on the mental a social wellness of the population affected. One of the causes of birth rate tumbling is the trend of later motherhood in modern societies and the infertility associated to diabetes and polycystic ovary syndrome (PCOS). PCOS is the leading cause for ovulatory infertility, being the most common endocrine and metabolic disorder, affecting women in reproductive age. Women suffering from diabetes frequently suffer from infertility and PCOS, while two-thirds of adult women with PCOS suffer from insulin resistance and hyperinsulinemia. The ERC-StG MitoSigAge funds research directed to understand the process of ageing with a focus on insulin/IGF-1 signalling (IIS) and its interaction with mitochondrial metabolism. PCOS blocks oocyte maturation and ovulation, suggesting a tight link between mitochondrial energy metabolism and oocyte development mediated by IIS. One of the applications emanating from this research lies in the identification of molecular targets to combat diabetes-associated sterility. The objective of the ERC-PoC is four-fold: First, identify evolutionarily conserved molecular targets that, when inactivated, suppress sterility associated to defective IIS. Second, identify existing drugs for the identified targets and ascertain which compounds have the best therapeutic potential. Third, perform the necessary patenting of the compounds for this new application and the initial steps towards the valorisation of the identified products and their commercial potential. Fourth, market studies to evaluate the commercial potential of our technology. These steps will bridge a scientific idea from basic research to therapeutic applications. If successful, it will provide important societal and economical benefits, helping combating the downsides associated to our modern ageing society.

Keywords: ageing,infertility,insulin,pcos,drug screening,high throughput screening,c elegans
NaaS - Newsroom as a service (NAAS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Newstag offers a new platform, connecting brands, news sources, NGOs and consumers - in a win-win-win business model to drive sales and awareness through a personalized news flow. We can turn any brand and organization into its own media source in a matter of days and help companies reach new markets worldwide at a fraction of the cost. The product is a B2B service called NAAS (Newsroom-As-A-Service) and gives companies the opportunity to integrate video news stories into their communication channels – to react and interact with events and engage their customers and audiences. With NAAS, any brand may create, embed and promote channels using its own content and get access to the world’s largest library of professional news video – with more than 40 000 truly engaging stories.

Keywords: news,media,communication,advertising,brands,business model