Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The heart of stroke: Pipes, Perfusion, Parenchyma (HEARTOFSTROKE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-03-01
End date: 2020-02-29
Duration (months): 60.0
Total project cost (EUR): 1499450.0
EU funding (EUR): 1499450.0
Participants: 1
Project status: CLOSED

My aim is to understand the cause of stroke in every single patient. Brain microinfarcts and macroinfarcts cause a major healthcare burden in Western societies both in terms of morbidity and costs. Cardiovascular thromboemboli from the heart, aorta and neck arteries are considered as the main cause. Still, the vast majority of brain infarcts are unexplained. In contrast to the thromboembolic explanation for brain infarcts, heart infarcts are known to be caused by local atherosclerotic plaque of the coronary arteries and impaired perfusion. This has led to successful preventive and therapeutic strategies against myocardial infarction. For brain infarcts, a blind eye is turned to local atherosclerotic plaque in the intracranial vasculature (Pipes) and impaired Perfusion as possible causes of macro and microinfarcts (Parenchyma). For the ‘3Ps’ (Pipes, Perfusion, Parenchyma) I have created new research fields based on innovative noninvasive arterial spin labeling perfusion MRI, perfusion reserve, perfusion territory and vessel wall MRI methods. In this project, I will go an important step beyond the state of the art by investigating the total intracranial burden of disease of these ‘3Ps’ and systematic evaluations in patients. Pipes: novel methods to visualise and characterise intracranial plaque including inflammatory plaque enhancement, intraplaque haemorrhage and calcification detection. Perfusion: novel methods to investigate hemodynamic impairment in areas with critically low perfusion with noninvasive arterial spin labeling MRI methods and perfusion reserve methods specific for each intracranial perfusion territory. Parenchyma: novel methods to detect microinfarcts. Technical innovations (Pipes, Perfusion) will be applied in synergy to explain micro and macroinfarcts (Parenchyma). Patient specific biomarkers will, similar to the heart, pave the way for designing preventive and therapeutic strategies aimed at reducing the burden of neurodegenerative diseases.

Keywords: stroke,cerebral blood flow,microinfarcts,circle of willis
Understanding spelling conflicts. A case study of new standard languages in the former Yugoslavia in the European context (SPELLFLICT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

This project will produce a descriptive model of orthographic controversies of four newly standardized South Slavonic languages since the 1990s, which will take into account other European languages with recent history of spelling reforms/changes. It is the first interdisciplinary and multiple comparative study, integrating top-down and bottom-up analysis of language standardization. It will provide a model for future studies and so launch me as a world-leader in sociolinguistics and language policy & planning of spelling codification. Since the beginning of mass education, standard languages have been undergoing spelling reforms/changes producing conflicts to a greater or lesser extent. The most recent were in Czech, Dutch, French, German and Portuguese in the 1990s. The conflicts related to writing among South Slavs have a long history that continues even today, causing discrimination and violence. In the last decade, 3 spelling reforms occurred (Montenegrin 2009, Croatian 2013, Bosnian 2018), creating (inter)national spelling conflicts, which gives an excellent comparative frame and timely opportunity for this study. My experience as a practicing Croatian orthographer has given me first-hand insights in the complexity of language codification. To understand better the relation between spelling and identity and to mitigate future conflicts, this study takes a comprehensive comparative approach that combines analysis of: A. speakers’ attitudes, B. media coverage (a discourse, argument and metaphor analysis of the relevant articles), C. the methodology and process of orthographic codification and D. socio-political context (stakeholders, legislation and procedures in a context).
NEW TRENDS IN ENERGY DEMAND MODELING (NEWTRENDS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Germany,Poland,Poland,Switzerland,Greece,Netherlands
Call: Socio-economic research conceptualising and modelling energy efficiency and energy demand (H2020-LC-SC3-EE-2019, 2019)
Start date: 2020-09-01
End date: 2023-10-31
Duration (months): 38.0
Total project cost (EUR): 1999292.5
EU funding (EUR): 1999292.5
Participants: 9
Project status: SIGNED

The EU 2050 Long-term Strategy develops scenarios for a climate-neutral EU in 2050 that aim at full deployment of low-carbon technologies or assume increased climate awareness of EU citizens translating into lifestyle changes, consumer choices, and a more circular economy. While these scenarios integrate societal trends, further progress is necessary to enhance the empirical basis for such New Societal Trends and their representation in models. New Societal Trends have potentially a large (increasing or decreasing) impact on energy consumption and might lead to cross-sectoral demand shifts that go beyond extrapolation of presently observed trends (continuous trends) and may speed up when they are embraced by larger parts of the society (disruptive trends). Such trends include in particular: digitalisation of the economy and of private lives, Circular Economy and Low-carbon industry, and Shared Economy, which will be the main focus of the present project. The novelty of our project arises from three perspectives: A thematic perspective identifying and quantifying how New Societal Trends affect energy demand, using trend-evolution pathways. A methodological perspective combining qualitative (foresight methods) with quantitative cross-sectoral modelling and exploring how energy demand models are to be improved to represent New Societal Trends. Several well-established models build the core of this project (INVERT/EE-Lab, FORECAST bottom-up model family, PRIMES energy system model, GEM-E3(-FIT)). All of which have been used extensively in the EU context for long-term projections and will be enhanced in this project. Further, policies will be represented in the demand models that influence such trends in the light of the EE1 Principle. Finally, a data perspective enhancing the empirical basis for modelling the impact of new societal trends through exploitation of new data sources (e.g. smart meter data) and empirical data (e.g. on behavioural changes).

Keywords: new societal trends,energy demand,model development,energy efficiency,prosuming,digitalisation,circular economy,shared economy,polices,scenarios,households,tertiary,transport,industry
Virtual and programmable industrial network prototype deployed in operational Wind park (VirtuWind)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Innovation actions
Countries involved: Germany,Germany,Germany,Ireland,Spain,Greece,Greece,United Kingdom,United Kingdom
Call: Advanced 5G Network Infrastructure for the Future Internet (H2020-ICT-2014-2, 2014)
Start date: 2015-07-01
End date: 2018-06-30
Duration (months): 36.0
Total project cost (EUR): 6340044.28
EU funding (EUR): 4874899.5
Participants: 10
Project status: CLOSED

With anticipated exponential growth of connected devices, future networks require an open solutions architecture facilitated by standards and a strong ecosystem. Such devices need an easy interface to the connected network to request the kind of communication service characterized by guarantees about bandwidth, delay, jitter, packet loss or redundancy. In response, the network should grant the requested network resources automatically and program the intermediate networking devices based on device profile and privileges. Similar requirement also comes from business applications where application itself asks for particular network resources based on its needs. Software Defined Networking (SDN) and Network Function Virtualisation (NFV) provide promising combination leading to programmable connectivity, rapid service provisioning and service chaining. As a part of 5G PPP programme, VirtuWind will develop and demonstrate SDN & NFV ecosystem, based on open, modular and secure framework showcasing a prototype for intra-domain and inter-domain scenarios in real wind parks as a representative use case of industrial networks, and validate the economic viability of the demonstrated solution. The wind park control network has been chosen as a professional application in VirtuWind as wind energy has now established itself as a mainstream of sustainable energy generation. By envisioning lower capital expenditure and operational expenditure costs in control network infrastructure, VirtuWind will play important role in assisting wind energy sector to achieve cost reductions. Further applicability of VirtuWind solution in other industrial domains will bring multifold benefits in their communication networks. The VirtuWind consortium consists of strong industry and academic partners covering the whole value chain of programmable networks. The consortium is striving for a common vision of creating industrial capability of SDN/NFV in Europe.

Keywords: software defined networking,network functions virtualization,programmable networks,industrial networks
Structure – Oxidative Stress relationships of metal oxide nanoparticles in the aquatic environment (SOS-Nano)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-11-01
End date: 2017-10-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The SOS-Nano project will address one of the most pressing cutting edge issues of econanotoxicology at present: to find a structural property of nanoparticles (NPs) to predict their potential toxicity in real aquatic environments, the final sink of released NPs. By using an in vivo natural water exposure system, SOS-Nano will test the suitability of two paradigms, recently demonstrated effective in vitro for ranking the hazard of metal oxide NPs: 1) NPs physical-electrochemical properties for predicting oxidative stress potential, and 2) oxidative stress generation for predicting biological impact. The experimental plan of SOS-Nano is totally innovative for design and methodology: the relationships between NPs structure and toxic activity will be studied under the influence of natural water properties, and the toxic potential will be ranked through a multi-tier system combining genomics and functional measurements. The science of SOS-Nano will have high impact: nanotechnology is one of the six EU Key Enabling Technologies selected by the EU Commission to address the industrial-economic competitiveness and the grand societal challenges in Europe by 2020 (US$ 2.5 trillion of world market, 2 million of employers by 2015). The lack of a sound human and environmental risk assessment of NPs is now the major limitation to the safe growth of this economic sector, and the EU research community is tasked with addressing the nanotechnologies development toward sustainability. The SOS-Nano project will represent the perfect opportunity for the applicant to join a cutting edge working environment in which she will realise her potential as a leading nanosafety expert in EU. The host Institution, the University of Exeter, is in the top 10 UK Universities which will provide exciting opportunities for gaining interdisciplinary experience of novel approaches in ecotoxicology and for networking with industry and international partners at the forefront of environmental nanoscience.

Keywords: nanoparticle,metal oxide,zinc,cerium,nickel,nanotoxicity,oxidative stress,bandgap energy,dissolution,oyster,crassostrea,marine environment,in vivo,water chemistry,surface properties
Joint programming actions to foster innovative CSP solutions (CSP ERANET)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: ERA-NET Cofund
Partnership: CSP ERANET (ERA-NET)
Countries involved: Spain,Spain,Italy,Israel,Germany,Switzerland,Greece,Türkiye,Portugal
Call: Joint programming actions to foster innovative energy solutions (H2020-LC-SC3-2018-Joint-Actions-2, 2018)
Start date: 2019-06-01
End date: 2024-11-30
Duration (months): 66.0
Total project cost (EUR): 13827426.0
EU funding (EUR): 4563050.58
Participants: 14
Project status: SIGNED

CSP ERANET is the result of a joint EU will for bridging the gap between research and commercial deployment in the Concentrated Solar Power (CSP) technology, so this technology can play a main role in the European renewable electricity generation in a medium term. For this purpose, the main European countries and regions, with roles to play in the future CSP deployment (industrial or academic stakeholders), have committed their economic resources to create big-scale funding synergies able to finance strategic CSP research. CSP ERANET aims to coordinate the efforts of Member States, Associated Countries and Regions towards achieving CSP SET Plan objectives, by pooling their financial resources to implement joint calls for R&I proposals, resulting on strategic projects with substantial volumes of investment, which cannot be allocated by individual countries or by the European Commission on their own. By pooling funds, CSP ERANET will achieve to finance large-scale projects implementing medium/high TRL research, which will accelerate the time to commercial deployment of affordable, cost-effective and resource-efficient CSP technology solutions. CSP ERANET constitutes a public-public partnership gathering 11 representatives from Member States, Associated Countries and Regions which have committed more than 9 million EUR public fund for launching the Cofund joint calls for proposals and more than 6 million EUR for the additional call to finance transnational research actions. During the 5 years of CSP ERANET the consortium intends to pool together financial resources from multiple countries, the Commission and the private sector, in order to invest more than 36 million euros (Cofund + Additional Call) in researching for innovative CSP solutions. This investment will finance 8 topics which were selected among the 12 R&I topics defined in the CSP Implementation Plan produced by the SET Plan temporary working group (TWG) on CSP.

Keywords: concentrated solar power,solar thermal electricity,research and innovation
A highly innovative and low-cost anti-counterfeiting solution which utilises micro-wires to maximise security and authentication (SecWire)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Counterfeiting of valuable and security documents is an increasingly serious problem worldwide. Banknotes, driving licenses, passport, ID cards, residence permits as well as event ticketing and stock certificates are all subject to increasingly frequent and accurate counterfeiting efforts. Each year, around €60B losses are experienced by governments as a result of counterfeiting. Current overt and covert anti-counterfeiting solutions are not effective at all as they are expensive to realize and can be easily overcome by skilled counterfeiters. To combat this, Wire Machine Technologies has developed SecWire, a ground-breaking anti-counterfeiting system which utilises ferro-magnetic micro-wires to offer high levels of IP security. The innovation behind the SecWire is in the manufacturing process which enables production of glass coated micro-wires of 2μm to 100μm diameter, small enough to be integrated in security paper. The SecWire is invisible and impossible to be removed, duplicated or deactivated. The micro-wires can be cut to any length and embedded (i.e. braided in the paper) into any products such as banknotes, passports, ID cards and event tickets. SecWire enables high security, it is durable and safe (microwires resist up to 600°C), it is 10 times cheaper than current solutions and it is highly scalable. During the feasibility assessment, a go-to-market strategy and the supply chain will be established as well as further IP protection will be pursued in other countries. Wire Machine Technologies will adapt SecWire for integration in different surfaces as paper, textile, plastic and polymers. They will also improve the production volume by increasing the number of working machines and expanding the production site. With the collaboration of secure document manufacturers and governments, extensive pilot tests will be performed to verify the anti-counterfeiting capacity of SecWire.

Keywords: document security,glass coated microwires,anti counterfeiting
New-generation cardiac therapeutic strategies directed to the activation of endogenous regenerative mechanisms (REANIMA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Israel,Austria,Germany,Germany,Germany,Spain,Spain,Switzerland,Netherlands,United Kingdom
Call: Regenerative medicine: from new insights to new applications (H2020-SC1-2019-Single-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2025-06-30
Duration (months): 66.0
Total project cost (EUR): 8000000.0
EU funding (EUR): 8000000.0
Participants: 12
Project status: SIGNED

Heart failure is a major epidemic world-wide, resulting in a large burden for society in deaths, morbidity and economic sustainability. The inability of the human heart to regenerate the myocardium lost due to acute myocardial infarction underlies a large part of chronic heart failure cases. To tackle this problem, REANIMA aims to deliver new therapies for heart regeneration, thereby reverting the conditions that lead to heart failure. Thus far, clinical trials based on introducing stem cells into the heart have not shown regenerative ability. In contrast, studies of spontaneous and induced heart regeneration in animal models strongly suggest a change in paradigm towards the reactivation of endogenous regenerative mechanisms. To develop this new path, REANIMA presents the first European basic-translational integrated effort in the cardiac regenerative field, with activities that span from the discovery of new targets in animal models to clinical trial design. REANIMA brings together knowledge on species that can regenerate their hearts –fish and amphibians–, animals that cannot regenerate their hearts –adult mammals– and human engineered heart tissues. Strong synergy between partners will allow REANIMA to identify new pathways in regenerative animals and design strategies for their reactivation in non-regenerative animals and human tissue. REANIMA incorporates industrial and academic partners specialised in translational and pre-clinical research, who will develop advanced therapeutic medicinal products and new translational platforms. REANIMA will thus establish a translational pipeline using cross-species gene/protein therapy products with high translational potential, thereby boosting the rapid transition from basic research to the design of clinical trials. We expect that REANIMA will change current paradigms underlying clinical efforts in regenerative cardiology by transforming basic knowledge on endogenous pathways into effective new therapies.

Keywords: heart regeneration,heart failure,acute myocardial infarction,tissue engineering,gene therapy,evolution
Program for Innovative Global Prevention of Streptococcus suis. (PIGSs)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Germany,Spain,France,Netherlands,Netherlands,Denmark,United Kingdom,Denmark
Call: Understanding host-pathogen-environment interactions (H2020-SFS-2016-2, 2016)
Start date: 2017-06-01
End date: 2022-08-31
Duration (months): 63.0
Total project cost (EUR): 4998103.75
EU funding (EUR): 4998103.75
Participants: 10
Project status: CLOSED

Streptococcus suis is an endemic porcine disease causing causing significant economic losses to the pork meat production industry in all countries where pigs are reared on a large scale. In some countries S. suis is the primary cause of mortality and morbidity in young pigs and the most frequent reason to prescribe antibiotics of the amino-penicillin group as a preventative measure. S. suis is also a zoonotic pathogen of humans and infections reported worldwide has increased significantly in the past years. Within S. suis many different types (serotypes, genotypes, pathotypes) exist causing problems in the development of control strategies targeting all types. Asymptomatic carriage in adult pigs is common and combined with a lack of knowledge on the host-pathogen-environment interactions, are the main reasons for failure to control the endemic nature of this pathogen. The project outputs will impact on on understanding host-pathogen-environment interactions of S. suis infections through the genome sequencing of 1200-1500 S. suis isolates from representative geographic areas of the major pork producing countries and performing genome-wide-association studies with invasive disease and asymptomatic carriage. New diagnostic methods will be developed for global monitoring of infection risk and tested on case-farms. Epidemiology studies will determine risk factors for invasive S. suis disease, including the role of co-infections, and for the first time properly assess the dynamics of the disease on a representative farm. We will increase our understanding of the virulence mechanisms involved in pathogenesis including interactions of S. suis with the innate immune system. The project outputs will strengthen the evidence base for prevention and control strategies through testing of novel conserved vaccine antigens in pigs and prevention strategies based on manipulation of the microbiota and stimulation and maturation of the innate immune system.

Keywords: streptococcus suis,host pathogen interactions,genomics