Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Biocatalytic Deracemisation of Atropisomeric Drug Candidates (RAMESES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-04-01
End date: 2027-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Drugs that are chiral due to slow bond rotation (atropisomeric) are becoming more prevalent, and atropisomerism is increasingly recognised as an asset rather than a hindrance in medicinal chemistry programmes. However, although some asymmetric routes to atropisomers are established, very few methods are applicable to ‘drug-like’ atropisomers – namely those that are heavily functionalised, hydrophilic and often heterocyclic target molecules, meaning that enantiomerically pure atropisomeric drug candidates are typically obtained by wasteful and inefficient resolution methods. This proposal will address this problem by developing the concept of enzymatic deracemisation – discovered incidentally during an ERC AdG study of controlled molecular motion – to the atropisomer classes typically found in medicinal chemistry development programmes. In contrast to classical means of obtaining enantiopure atropisomers, this proposed biocatalytic method overcomes the yield and waste limitations of classical resolution and is uniquely applicable to the polar, water-soluble drug candidates for which existing asymmetric methods fail. The method stands out as sustainable, versatile and capable of making potential chiral drugs of enormous value and will be transformative for how the chemical and pharmaceutical sectors produce atropisomeric drug molecules. The originality of the project stems directly from a newly discovered chemical process unique to our laboratory. The Research Team is composed of diverse specialists in synthesis, biocatalysis, complex reaction networks and drug development. Development of the method will involve close partnership with industrial partners to identify enzyme classes, methods and target molecules for use as case-studies to quantify the benefits of the technology.
Computational Methods to Analyse Intra-operative Adverse Events in Surgery at Scale (CompSURG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 1951931.0
EU funding (EUR): 1951931.0
Participants: 1
Project status: SIGNED

The operating room is the most frequent location for hospital-related errors. However, intra-operative adverse events (IAEs) are underreported, which impedes their large-scale analysis, the definition of appropriate safety measures and the development of intra-operative support systems to reduce their occurrence. Recent manual video-based assessments of surgical procedures have shown that not only are IAEs frequent, but also that near miss intra-operative events, previously thought to be inconsequential, are in fact predictors of major errors and correlate with complications and poor surgical outcomes. We leverage these recent findings to propose a radically new, computational approach to improve intra-operative surgical safety. We propose to focus on automatically detecting and analyzing IAEs in endoscopic videos via novel computer vision methods that model the detailed semantics of tool-tissue interactions, as needed to study the activity patterns leading to these critical events. We will first generate a multi-centric, multi-procedure dataset annotated with tool-tissue interaction semantics and IAEs. We will then develop a new fully differentiable neural network model of surgical videos relying on an intermediate graph representation to disentangle the surgical semantics. Finally, we will introduce new training methods for scaling these approaches to different types of surgeries and centers using a limited set of annotations. These computational methods will allow the automated reporting and analysis of IAEs at a scale unfeasible with manual methods. We will use them to analyze patterns of IAEs and to identify the activities and phases of the surgical procedures that would benefit from new safety measures. We will also design a prototype for intra-operative support. We believe that this project will help to improve surgical safety and hence greatly benefit patient care.

Keywords: surgical video analysis deep learning semi supervised learning laparoscopic surgery intra operative adverse events safety in surgery
New perspectives on the box counting dimension of sets and measures (NewBoxDim)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Hungary
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 141782.4
EU funding (EUR): 141782.4
Participants: 1
Project status: SIGNED

Fractal geometry is a young, very active and rapidly growing field of research that is connected to different areas of mathematics and the natural sciences. Roughly speaking, dimension theory is concerned with measuring the ‘size’ of sets by defining different notions of dimension. At the center of NewBoxDim is the box counting dimension which is a fundamental concept within mathematics that has found applications outside of mathematics as well. The main objective of NewBoxDim is to open new perspectives on the study of the box dimension of sets and measures by exploring three very recent alternative approaches. In the first approach, the goal is to develop unifying machinery based on thermodynamic formalism in order to tackle a long-standing open problem about the existence of the box dimension of self-affine sets. In the second approach, we aim to fuse ideas from dimension theory and methods from percolation theory in a novel way to study the fine scale structure and connectivity properties of different fractal percolation models. The third and final objective of NewBoxDim is to advance our understanding about the time evolution of the chaos game whose convergence rate is determined by the box dimension of the measure driving this stochastic point process. We aim to obtain more nuanced information by making an interesting connection to the L^q spectrum (also known as generalized fractal dimensions) of the measure and characterizing the measure which minimizes its box dimension. As an interdisciplinary application, our results on the chaos game could have a direct impact on the Chaos Game Representation (and its variants) which is a method that was developed to analyze genomic sequences in bioinformatics.

Keywords: dynamical systems,fractal geometry,dimension theory,stochastic processes,iterated function system,percolation theory,thermodynamic formalism,geometric measure theory,cover time,box dimension
Multidimensional model of tourism verticals driving the sustainable balanced growth among rural & remote grids and urban clusters of rural regions, fostering macro-regional cooperation (TOURAL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Greece,Bulgaria,Romania,Ukraine,Türkiye,Croatia,Italy,France
Call: Fostering socio-economic development and job creation in rural and remote areas through cultural tourism (HORIZON-CL2-2023-HERITAGE-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2999927.5
EU funding (EUR): 2999927.5
Participants: 20
Project status: SIGNED

EU rural and remote areas demonstrate a wide range of qualities, while facing a unique set of challenges. To this end, EC put forward a “Long Term Vision for Rural Areas”, identifying specific challenges and opportunities, and proposing a Rural Action Plan. A major challenge is the diversification of economic activities beyond the traditional agriculture-farming-forestry sectors, as enabler for stimulating economic growth. Evidently, tourism could become an anchor for economic development of rural and remote areas. Motivated from the above considerations, TOURAL will focus on cultural & creative tourism as drivers for sustainable development, paying at the same time a premium to the EC Tourism Transition Pathway requirements, within the context of smart multi-destination and multi-dimensional tourism offerings empowered by macro-regional tourism cooperation and integrated local value-chains. TOURAL proposes a model to support the touristic development of participating rural regions, balancing the growth of their urban clusters with the untapped growth potential of their remote and rural grid cells. Our modelling approach will be multi-dimensional in terms of addressing complementary tourism verticals/niche sectors (underwater cultural & nature heritage tourism, cultural & creative tourism, cultural science tourism, silver tourism); participatory in terms of co-designing policy pathways and tourism offerings/services, co-creating business models and tourism products, and co-validating small-scale tourism services implementations; and integrated in terms of joint planning and business development with integrated value-chains, policymaking and cross-border cooperation, at macro-regions level. Our scope of interventions includes 3 regions from the Adriatic-Ionian macro-region (Italy, Croatia, Greece), and 3 regions from the Black Sea Basin (Bulgaria, Romania, Ukraine).

Keywords: underwater cultural and nature heritage tourism ucnht cultural and creative tourism cct cultural science tourism cst silver tourism slt multi dimensional modelling multi objective modelling
Research and development of a highly automated and safe streamlined process for increased Lithium-ion battery repurposing and recycling-Hop on (REBELION - HOP ON)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Spain,Slovakia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 42.0
Total project cost (EUR): 306147.5
EU funding (EUR): 306147.5
Participants: 2
Project status: SIGNED

The main contributions of TUKE as the new partner in the project REBELION are increased level of tools automation, saving time in main operations of the WP6, i.e. increasing the efficiency of the recycling line, improvement of safety and environmental friendliness of working conditions, minimization of waste volume via application of NDT methods. There will be developed 8 new sophisticated tools for the robotic line, fully compatible with up to date control system of the line. At consortium level, the REBELION-Hopon project enlarges outreach of the partners’ R&I actions and provides access to new talent pools, bringing additional experts with essential expertise in robotics dismantling and fragmentation from nuclear industry to the team. At the level of the new partner, new competencies and skills for working in transnational projects including research management and dissemination and exploitation will be acquired because of 11 partners with mixture of competencies and working methods. Commercial impact results from competitive advantages based on technical contributions of the new partner mentioned above. It will be benefit for future producers and also for European economy.

Keywords: tools,cutting,robotic line,rotary blade
Advancing FronTier Research In the Arts and hUManities (ATRIUM)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Services and infrastructures
Action type: Research and Innovation actions
Countries involved: France,Poland,Austria,Serbia,Czechia,Italy,Germany,Netherlands,Greece,Belgium,Cyprus,United Kingdom,Portugal,Sweden
Call: Research infrastructure services advancing frontier knowledge (HORIZON-INFRA-2023-SERV-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 9849493.75
EU funding (EUR): 9849493.75
Participants: 30
Project status: SIGNED

Advancing FronTier Research In the Arts and hUManities (ATRIUM) will exploit and strengthen complementarities between leading European infrastructures: DARIAH, ARIADNE, CLARIN and OPERAS in order to provide vastly improved access to a rich portfolio of state-of-the-art services available to researchers across countries, languages, domains and media, building on a shared understanding and interoperability principles established in the SSHOC cluster project and other previous collaborations. Arts and Humanities is a very diverse field, covering a range of disciplines and communities of practice that have different epistemological and methodological foundations: an archaeologist and an art historian studying a Mycenaean fresco will have distinct goals and use different approaches to describing their objects of research. A literary scholar and a linguist will come to a textual corpus with radically different senses of what a corpus is and what questions can be asked of it. Yet research infrastructures in the Arts and Humanities domain must cater to a very wide range of stakeholders and offer services that cut across discipline-specific boundaries. ATRIUM will tackle this heterogeneity within the Arts and Humanities by going deep and wide at the same time: on the one hand, ATRIUM will make a groundbreaking contribution to the consolidation and expansion of services, including data services, specifically in the field of archaeology, while, on the other hand, facilitating access to a wide array of essential text, image and sound-based services that benefit a number of other disciplines within the Arts and Humanities, and cover all phases of the research data lifecycle (creating, processing, analyzing, preserving, providing access to and reusing).
Convergence of unitary representations (CONUREP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2025-COG, 2025)
Start date: 2026-07-01
End date: 2031-06-30
Duration (months): 60.0
Total project cost (EUR): 1981393.0
EU funding (EUR): 1981393.0
Participants: 1
Project status: SIGNED

Understanding the unitary representations of a given group G is one of the most persistent problems of mathematics. If G is the integers, the ensuing theory is that of the Fourier transform. If G is the Heisenberg group, then the resulting representation theory is the theory of matrix models of Quantum Mechanics. Accelerating, if G is the absolute Galois group of the rationals, the theory is described by the Langlands program. My goal is to understand the finite dimensional (f.d.) unitary representations of discrete groups through the lens of how they can converge to the regular representation. I describe both weak and strong forms of convergence and focus mainly on strong convergence. I first ask which groups have f.d. unitary representations that strongly converge to their regular representation? What if we require representations to factor through permutation groups? These questions are deep, wide-ranging, and push far beyond the state-of-the-art. Next I ask to what extent strong convergence of f.d. unitary representations is generic, when we have a way to randomize representations. In particular this applies to the fundamental groups of closed surfaces, which are a test bed for the current program. In many cases randomization is the only tool we know to establish strong convergence, so we have as yet no explicit examples of the phenomenon that the proposal in centered on! We present an algebraic candidate that is intimately related to Selberg’s Eigenvalue Conjecture in automorphic forms. Most of the above questions have spectacular consequences to spectral gaps of locally symmetric spaces, a connection that I discovered with Hide. We do not understand this outside special cases yet. I ambitiously aim to completely describe the connections between strong convergence of representations of a lattice and their induced representations of the ambient Lie group. Finally, we imagine what lies beyond strong convergence and whether random matrix theory can take us there.

Keywords: unitary representation,spectral gap,discrete groups,c algebras
Democratising digital farming through tailored open source and open hardware solutions (OpenAgri)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: Netherlands,Greece,Belgium,Serbia,Poland,France,Cyprus
Call: Open source solutions for edge, cloud and mixed model applications to strengthen production and administrative capacities in agriculture (HORIZON-CL6-2023-GOVERNANCE-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 4999987.5
EU funding (EUR): 4999987.5
Participants: 18
Project status: SIGNED

The last decade has seen an explosion of interest and investment in the use of Agricultural Digital Technologies (ADSs). The use of ADSs is seen by many as an opportunity to increase the economic and environmental performance of the agricultural sector. Despite great efforts and resources spent, uptake of ADSs by EU farmers has been limited for reasons like a) the frequently excessive cost of ADSs, b) the low trust that farmers have on ADSs and data sharing, for a variety reasons, and c) the weak network connectivity problems experienced by farms in remote areas, which affect the performance of the ADS. The overall aim of the OpenAgri project is to democratise digital farming by enabling the development and deployment of innovative cost-effective energy-efficient OS software and open hardware-based ADSs that can operate at a high performance even in remote areas with weak connectivity. This will be achieved by a) ensuring the co-creation of ADSs by engaging farmers and farm advisors in participatory prototyping activities inspired by the makerspaces approach; and b) providing access to a number of reusable OS software services designed to support the edge and mixed computing mode, and a “sociotechnical infrastructure”. Using a multi-actor approach, OpenAgri will involve farmers, ADSs providers, farm advisors and scientists in 14 Sustainable Innovation Pilots (SIPs) in ≥10 countries across Europe, and guide them in co-creating and piloting edge, cloud and mixed-model ADSs addressing important challenges of agricultural production. 5 SIPs have been pre-selected and 9 more will be awarded through an Open Call, enabling a dynamic response to a changing policy and technology landscape. Finally, building on a thorough analysis of EU agriculture and the results from the SIPs, OpenAgri will create a Decision Support Tool that will allow Policy Makers, Farmers and Farm Advisors to select the best possible cloud, edge or mixed ADSs for any given set of conditions.

Keywords: digital agriculture,co creation,sustainable innovation,makerspaces,open innovation
Alliance4Life Bridging the Research and Innovation Gap in Life Sciences (A4L_BRIDGE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Czechia,Slovakia,Poland,Croatia,Estonia,Lithuania,Latvia,Slovenia,Bulgaria,Romania,Ireland,Hungary
Call: European Excellence Initiative (HORIZON-WIDERA-2023-ACCESS-03, 2023)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 4820170.26
EU funding (EUR): 4722788.12
Participants: 13
Project status: SIGNED

The persisting R&I gap between Western and Eastern Europe is a major challenge to the EU. It includes under-developed R&I ecosystems, a lower ability to attract and retain talents, single-track research careers with a lack of modern HR, and fragmented industry-academia collaboration. To improve the situation in Central and Eastern Europe (CEE), Alliance for Life Sciences (Alliance4Life) was formed by 12 progressive health research institutions and universities in 11 CEE countries. Since 2018 it has become a lively community and role model of modern institutional governance and excellent research in CEE, piloted strategic institutional reforms, and succeeded in influencing national R&I reforms and EU policy. With the A4L_BRIDGE project, the alliance focuses on a broader implementation of the successfully piloted strategic changes toward enhanced attractiveness, competitiveness, and innovation strength, and newly also addresses excellence in higher education. The scientific collaboration will be boosted by a Virtual Research Centre, connecting different research groups, and thanks to seed funding, initial research projects with IP originating in CEE will be prepared to be developed into RIA projects for Horizon Europe. The alliance will develop a complex educational matrix, including mentoring, e-learning, and international internships, targeting both academic and non-academic staff in all career stages. The Industry Relationship Platform will stimulate knowledge transfer and partaking in applied research projects. Societal actors will be invited to shape the research agendas and will be addressed at events for end users of health research results. Events, webinars, and dissemination activities will target national stakeholders and policymakers, promoting ERA values and supporting the empowering of low-performing regions in their R&I upscale. The A4L_BRIDGE project will thus significantly contribute to bridging the gap in R&I performance in the EU.

Keywords: life sciences,alliance4life,institutional reforms,research assessment reform,industry academia linkages,quadruple helix,innovation ecosystem