Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Real-time diffusion NMR analysis of mixtures (DINAMIX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: France
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2024-12-31
Duration (months): 71.0
Total project cost (EUR): 1499307.0
EU funding (EUR): 1499307.0
Participants: 1
Project status: SIGNED

Chemical samples often come as solution mixtures. While advanced analytical methods exist for samples at equilibrium, the information on components and their interactions that may be accessed for the frequent and important case of out-of-equilibrium mixtures is much more limited. The DINAMIX project will tackle this challenge and provide detailed, molecular-level information on out-of-equilibrium mixtures. The proposed concept relies on diffusion nuclear magnetic resonance (NMR) spectroscopy, a powerful method that separates the spectra of mixtures’ components and identifies interactions, in correlation with structural insight provided by NMR observables. While classic experiments require several minutes, spatial encoding (SPEN) in principle makes it possible to acquire data orders of magnitude faster, in less than a second. The PI has recently demonstrated that SPEN diffusion NMR is a general concept, with the potential to provide real-time information on out-of-equilibrium mixtures. These include a vast range of systems undergoing chemical change, as well as the important class of “hyperpolarised” solution mixtures generated by dissolution dynamic nuclear polarisation (D-DNP). D-DNP indeed provides dramatic NMR sensitivity enhancements of up to 4 orders of magnitude, which however last only for a short time in solution. In the DINAMIX project, we will develop i/ novel robust and accurate real-time diffusion NMR methods, ii/ advanced algorithms for data processing and analysis, iii/ protocols for sensitive component identification. We will exploit the resulting methodology for mechanistic investigations into catalytic organic and enzymatic reactions. The real-time diffusion NMR analysis of systems that are out-of-chemical equilibrium, far-from-spin-equilibrium or both will provide transformative insight on mixtures, with applications in chemical synthesis, supramolecular and polymer science, structural biology, and microstructural studies in materials and in vivo.

Keywords: nmr spectroscopy,hyperpolarisation
A solution for plastic waste pollution (SOLFORPLAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-02
End date: 2022-06-01
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

Since the 1970s, the mismanagement of plastic waste has been increasingly threatening our health and environment. Rather than been reduced, plastic production is growing exponentially. By 2050, the estimation of plastic waste in landfills or in the natural environment verges on 12 billion metric tons, if current production and waste management trends continue. Societies are raising awareness about this concern, although our dependency makes nearly impossible to imagine a world without plastics. This urges for a solution making plastic production and degradation sustainable. To date, important efforts have been made to isolate and identify unique microorganisms capable of utilizing plastics as a carbon source. Although there is empirical evidence of it, the rates of biodegradation are still very low. In SOLFORPLAS project, we will apply cutting-edge biology tools, including fermentation and analytical processes, together with state-of-the-art methods in industrial microbiology research, to investigate plastic biodegradation using a highly-optimized strategy that combines an extruder and a bioreactor. The innovative combined strategy will integrate physical, chemical and biological treatment, which will mimic the whole biodegradation process taking place in worms. Multiple polymer characteristics will be monitored to determine/quantify its biodegradation. Overall, SOLFORPLAS project aim at stablishing a combined strategy to carry out plastic biodegradation as a solution for plastic pollution, one of the biggest environmental that humans are facing in this century.

Keywords: extrusion process
Random Matrices, Random Graphs and Circular Elements (RanMatRanGraCircEl)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Switzerland,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 178207.68
EU funding (EUR): 178207.68
Participants: 2
Project status: CLOSED

Random matrix statistics are a paradigm for the collective behaviour of many strongly correlated random variables. The proposed projects will fundamentally advance our knowledge about random matrices in novel directions. We study spectral properties of random matrices when the matrix size becomes large. More specifically, we establish the universality of the fluctuations of the smallest singular value of almost square random matrices with independent entries. Moreover, we determine the asymptotic eigenvalue density of non-normal random matrices with correlated entries of general expectation and the Brown measure of operator-valued circular elements. We also obtain a central limit theorem for the difference of the linear statistics of a matrix with independent, identically distributed entries and its minor. Furthermore, we analyse the spectra of random graphs. Specifically, a transition in the eigenvalue fluctuations of very sparse Erdos-Renyi graphs, the eigenvector delocalisation of directed Erdos-Renyi graphs as well as the extreme eigenvalues and eigenvectors of preferential attachment graphs. Finally, we investigate a variational problem motivated by wireless communication. The techniques proposed for these projects comprise a variety of tools from analysis (spectral theory, variational methods), probability theory (stochastic differential equations, large deviation bounds) and mathematical physics (self-consistent equations). For the purpose of these projects, the tools mentioned above will be developed further.

Keywords: eigenvalue,eigenvectors,universal fluctuations,erd s r nyi graphs,non hermitian random matrix
PRACE 4th Implementation Phase Project (PRACE-4IP)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: e-Infrastructures
Action type: Research and Innovation actions
Countries involved: Spain,Austria,Germany,Spain,Ireland,Israel,Austria,Germany,Germany,Spain,Italy,Germany,Cyprus,Norway,Belgium,Finland,Slovakia,Switzerland,Norway,Türkiye,Türkiye,Poland,Poland,Poland,Slovenia,Slovenia,Sweden,Sweden,Sweden,Sweden,Greece,Hungary,Bulgaria,Poland,France,France,France,Czechia,Netherlands,Denmark,United Kingdom,Portugal,Portugal,Portugal,United Kingdom
Call: Pan-European High Performance Computing infrastructure and services (H2020-EINFRA-2014-2, 2014)
Start date: 2015-02-01
End date: 2017-12-31
Duration (months): 35.0
Total project cost (EUR): 16354408.25
EU funding (EUR): 15000000.0
Participants: 50
Project status: CLOSED

PRACE, the Partnership for Advanced Computing, was established in May 2010 as a permanent pan-European High Performance Computing service providing world-class systems for world-class science. Six systems at the highest performance level (Tier-0) are deployed by Germany, France, Italy and Spain providing researchers with over 9 billion core hours of compute time. HPC experts from twenty-five member states - funded in part in three implementation projects - enabled users from academia and industry to ascertain leadership and remain competitive in the Global Race. Currently PRACE is preparing for PRACE 2.0, the successor of the initial five year period. The objectives of PRACE-4IP are to build on and seamlessly continue the successes of PRACE and start new innovative and collaborative activities proposed by the consortium. These include: assisting the transition to PRACE 2.0; strengthening the internationally recognised PRACE brand; continuing advanced training which so far provided more than 15.000 person-training days to over 4700 persons, preparing strategies and best practices towards exascale computing, coordinating and enhancing the operation of the multi-tier HPC systems and services, and supporting users to exploit massively parallel systems and novel architectures. The proven project structure will be used to achieve each of the objectives in six dedicated work packages. The project will continue to be managed by Jülich. The activities are designed to increase Europe's research and innovation potential especially through: seamless and efficient Tier-0 services and a pan-European HPC ecosystem including national capabilities; promoting take-up by industry and special offers to SMEs; analysing new flexible business models for PRACE 2.0; proposing strategies for deployment of leadership systems; collaborating with the ETP4HPC, the coming CoEs and other European and international organisations on future architectures, training, application support and policies.

Keywords: partnership for advanced computing,prace,high performance computing,research infrastructure,innovation,support for industry,training,education,international cooperation
Free Respiratory Evaluation and Smoke-exposure reductionby primary Health cAre Integrated gRoups (FRESH AIR)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Uganda,Belgium,Greece,Netherlands,United States,Netherlands,United Kingdom,Denmark,United Kingdom,Viet Nam,Denmark,Kyrgyzstan,United Kingdom,United Kingdom
Call: Global Alliance for Chronic Diseases. Prevention and treatment of lung diseases (H2020-HCO-2015, 2015)
Start date: 2015-10-01
End date: 2018-09-30
Duration (months): 36.0
Total project cost (EUR): 2990750.0
EU funding (EUR): 2990750.0
Participants: 15
Project status: CLOSED

FRESH AIR is a 3 year project which addresses the urgent need to prevent, diagnose and treat lung diseases in LMICs and other low-resource settings where the greatest burden of disease is experienced. Our Consortium brings together leading international respiratory researchers, clinicians and policy experts from EU member states and the US who have expertise and experience of the challenges of implementation in LMICs and healthcare providers, policy makers and implementers from four countries that represent very different low-resource settings. Members will work together to adapt and test innovation and evidence-based practice in the prevention, diagnosis and treatment of lung disease in four low-resource settings in Uganda, Kyrgyz Republic, Vietnam and Greece with high levels of tobacco consumption and exposure to Household Air Pollution (HAP). In so doing, the Consortium will transfer skills and technology from EU member states and the US to new contexts and explore a range of implementation science research questions. The new knowledge this generates will be widely disseminated nationally, regionally and internationally, ensuring the scale-up of interventions tested by the project and global impact of research findings. The project will also provide new perspectives on policy issues of concern to EU members, increase the international profile of EU funded research on key health challenges and open up markets for healthcare innovations. The project has 7 specific objectives focused on the following: 1. Identifying factors influencing the implementation of evidenced-based interventions 2. Exploring which awareness-raising approaches are most effective in achieving behaviour change 3. Adapting interventions that provide smoking cessation support 4. Testing innovative diagnostic methods for COPD 5. Promoting pulmonary rehabilitation as a low cost treatment 6. Reducing children’s risk of lung damage 7. Generating new knowledge, innovation and scalable models.

Keywords: tobacco,smoking,lung diseases,primary care,household air pollution,pulmonary rehabilitation,education
Multicompartmental Designs For Protocells (Protoeukaryotes)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Protocells are artificial mimics of cellular systems exhibiting some of the quintessential characteristics of living systems such as compartmentalization, replication and selective exchange of chemical species with the environment. Apart from enabling better understanding about the origin of life, protocells can also be perceived as micromachines which can be programmed to perform functions such as clinical diagnosis, drug delivery, remote sensing, environment detoxification, etc. The range of applications for protocells can be broadened by increasing their structural complexity which would enable complex functions. However, to date the structural complexity of protocellular models has been minimal. Eukaryotic cells are model systems for complexity with compartmentalization into membrane bound organelles interacting through selective exchange of metabolites resulting in complex chemical networks which make possible smart functions such as feedback regulation and homeostasis. No parallel of this hierarchical organization exists in protocell literature. The aim of this proposal is to address this issue by design and construction of multicompartmental protocell models capable of complex functions such as self-regulation, locomotion and light harvesting. The interaction between the various compartments will be enabled by constructing gates across their membranes using stimuli responsive polymers to allow compartments to activate pathways which can affect the function or metabolite level of another compartment, leading to self-regulation of function or metabolite levels in the protocell. It is in this regard that the previous expertise of the applicant (Dr. Pavan Kumar) in constructing gates to control the transport in nanochannels will be applied to the multi-disciplinary and cutting edge field of protocells in which the hosting group at the University of Bristol (under the leadership of Prof.Stephen Mann FRS) has made tremendous progress in the last few years.

Keywords: protocell,feedback loops,enzyme cascades,locomotion
Majorana neutrino discovery strategy with CMS (MajorNet)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Switzerland,Switzerland
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2024-04-30
Duration (months): 76.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1271093.01
Participants: 2
Project status: SIGNED

The Large Hadron Collider at CERN is successfully operating at a record-breaking energy and is expected to deliver an enormous dataset of 300/fb of proton-proton collisions in the next 6 years. I propose to take advantage of both the unprecedented collision energy and the large number of events to be recorded in order to search for signs of new particles which could uncover the nature of dark matter, provide an explanation for the matter-antimatter asymmetry of the universe or answer questions about the origin of neutrino masses. To achieve this, I will build on my expertise devising and organizing new physics searches with leptons and will establish and lead a new multi-signature research programme at the CMS experiment. This programme will exploit both the intensity and energy frontiers opening up at the LHC and can be further expanded at the high-luminosity LHC (HL-LHC). Since the masses and couplings of the new particles are unconstrained, my proposed search strategy will be such that a wide mass range will be covered also encompassing many orders of magnitude in the coupling strength.

Keywords: majorana neutrino,dark matter
Hemozoin Detection using Nitrogen-Vacancy centers in Diamond (HEMOTECT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Advances in chemistry, biology and medicine have been historically promoted by physical tools, with notable examples x-ray crystallography, nuclear magnetic resonance spectroscopy and microscopy. A new physical tool has recently emerged as a unique electromagnetic-field sensor and it is based on the exploitation of the remarkable magneto-optic properties of one particular color center in diamond, known as the Nitrogen-Vanancy (NV) center. In recent years, nano-scale sensors using NV centers have enabled the detection of nanoscale ensembles of nuclear and/or electron spins, and high-resolution imaging of living cells, to name few of the most outstanding sensing demonstrations using NV centers. We propose the development and implementation of a high-throughput sensor utilizing NV centers in diamonds, for the sensitive, quantitative and rapid detection of ensembles of paramagnetic spins in liquids and crystals. Sensitive paramagnetic-spin sensors will enable the possibility for nanoscale sensing and imaging of the structure and electron configuration of biomolecules, and most importantly, of real-time observations of chemical and biological processes. The principal motivation for the proposed project is the implementation of the developed sensor for the detection of paramagnetic crystals, and in particular of synthetic hemozoin crystals. Synthetic hemozoin crystals have identical magneto-optic properties with naturally-grown hemozoin crystals, a byproduct of malaria infection. A label-free, high-throughput sensor of hemozoin crystals, with sensitivity limits better than the currently used malaria diagnostic techniques will pave the way for a new diagnostic tool that could be used for the early diagnosis of malaria, and therefore, contribute to the eradication of one of the deadliest diseases in the world.

Keywords: nitrogen vacancy centers,electron spin resonance spectroscopy,paramagnetic spin sensor,label free sensor,hemozoin crystals
Tick-borne encephalitis Targeted by Human Active NK cells (Tick ThaNK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2021-03-03
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

The aim of this project is to determine the role of natural killer (NK) cells, effector players of the innate immune system that target virally infected cells and tumor cells, in the infectious disease Tick-borne encephalitis (TBE). By elucidating their function either in enhancing or suppressing the disease in two different compartments, central nervous system (CNS) and peripheral blood, we seek to generate knowledge that will provide new insights into innate immunity that could lead to novel strategies to improve treatments for infectious diseases. This project is intended to take place mainly in the Center of Infectious Medicine from the Department of Medicine at Karolinska Institutet (KI) in Stockholm. To complement the scientific training proposed, a secondment of two months will be carried out at the VU University Medical Center in Amsterdam, Netherlands. Overall, the goal of the present application is to support the restart of the scientific formation of the applicant, who has made a 2-year career break due to maternity leave. The short-term objective of the current study is to provide training of the researcher in advanced cellular characterization, labeling, and bio-imaging techniques, synergistically with trans-European mobility, reinforcing her scientific, managerial and leadership qualities. A mid-term objective is the progress of the researcher’s career in science and the broadening of her scientific horizons, and a long-term aim is the Fellow’s setting as an independent investigator.

Keywords: natural killer cells,flavivirus,blood brain barrier,cerebrospinal fluid
Minimal invasive x-ray source enabled by a novel vacuum packaging technique (xMEMSRAY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-01-01
End date: 2015-12-31
Duration (months): 12.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

In this project we aim to demonstrate and test a MEMS-based miniaturized electronic x-ray source enabled through a vacuum packaging concept developed under an ERC AdG. The source should be capable of delivering doses up to approximately 1 Gy/min at a 2 mm distance while still having a millimetre overall size. This will be achieved by combining the vacuum packaging technique with a pointed field emission array developed in another project. The goal of the project is to demonstrate key functionalities and take the technology to TRL 4 with the ambition establish collaboration with leading company in brachytherapy.

Keywords: mems,x ray,vacuum packaging,radiotherapy,medical technology