Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
First edge sensing and imaging real-time processing drone for precision farming (Beagle)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2490000.0
EU funding (EUR): 2490000.0
Participants: 1
Project status: SIGNED

At Beagle Systems, we address three key global challenges in the agriculture sector. Firstly, escalating energy prices and input costs have significantly burdened farmers, with inorganic fertilizers and pesticides costs increasing by 2.5 times since 2020. Secondly, the environmental consequences of traditional agriculture, including soil degradation and biodiversity loss, are substantial. The EU alone consumes over 10 million tonnes of inorganic fertilizers and 350 thousand tonnes of pesticides annually, leading to sizeable CO2 emissions. Lastly, the demand for rapid and precise decision-making in agriculture is higher than ever due to the narrow windows for effective input application. Beagle System presents the world's first edge sensing and imaging real-time processing drone-as-a-service for precision farming; our Beagle M drone uses edge data processing, edge imaging, power management, and edge communication and integration technologies to reduce inorganic fertilizers and herbicide use by up to 95%, By enabling precise spot spraying, aligning with sustainability goals and offering a financially viable alternative for farmers. Our high degree of novelty stands to disrupt the traditional crop protection market and drive a significant shift towards more sustainable agricultural practices. Beagle Systems' M drone is engineered to work seamlessly with current agricultural practices. It translates aerial data into commonly used formats, communicates effectively via 5G for real-time data transfer, and incorporates advanced sensors for accurate field analysis. Additionally, it supports adaptable software applications and autonomous operations with AI, facilitating sophisticated data handling and decision-making in precision farming.

Keywords: geo information and spatial data analysis,edge computing,edge processing,big data,artificial intelligence,soil management,environmental protection
Symbiotic endophytes from wild plant species for a more sustainable and resilient agriculture (SymBio)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

CropBiome develops selective beneficial microbial formulations to improve overall crop performance. Our microbes are uniquely isolated from wild crops, where they naturally improve plant resilience in harsh conditions. When formulated and applied to standard crops, our microbes have conferred increased nutrient use efficiency, significantly reducing application of nitrogen, and have also improved drought and disease resistance. Our company is in a leading position to utilize this approach because it has already developed products and demonstrated their application in field plot trials in Europe (Ireland, UK, Ukraine, Poland & Romania) for cereal production. By increasing the number of field plot trials, commercial collaborators and associated geographical locations, this EIC project will help more rapidly validate our key product technologies, as per agri-sector requirements and certification, in preparedness for market exploitation.

Keywords: biotechnology,agriculture,agronomy,agricultural products,endophytes,seed treatments,plant sciences
Multi-Scale Investigation of the Chemistry of the Atmosphere of Venus (MuSICA-V)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-12-01
End date: 2025-11-30
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: SIGNED

Venus is the closest planet to Earth. Despite a similar size and mass, there are differences between the two planets. At the surface, the temperature can reach 730 K with a pressure of 90 bar, and a composition of 96 % of carbon dioxide. Venus hosts a global cloud layer between 45 and 70 km of altitude, with composition and temperature-pressure conditions close to the Earth's stratosphere and complex chemistry with both sulphur and water cycle. This global cloud layer plays a key role in the radiative equilibrium of the atmosphere. Therefore, it is fundamental to study its composition and dynamics at all spatio-temporal scales to understand the atmosphere of Venus. Despite decades of measurements and modelling, there are still many unknowns about the chemistry of the Venusian atmosphere. The Project MuSICA-V (Multi-Scale Investigation of the Chemistry of the Atmosphere of Venus) conducted at LATMOS will develop new and ambitious numerical models using a hierarchy of models: a Planetary Climate Model (PCM), mesoscale and Large-Eddy Simulation (LES) models all coupled to a photochemistry scheme. These three models are performed with different resolutions and would help capture the spatio-temporal variability of the chemistry over different scales as never before, and will increase the understanding of the coupling of the dynamics and chemistry from the large-scale to the small-scales. The proposed effort is perfectly timed and relevant to ongoing and planned international Venus exploration activities: ESA mission EnVision, and NASA missions DAVINCI and VERITAS, were all three selected to launch in the next decade. The main objectives of these missions are to study the surface and the dynamics both inside and below the clouds. The project will simulate predictions for chemistry variabilities to produce observables for past and future missions, to improve the interpretation of the measurements.

Keywords: planetary science atmospheric chemistry turbulent mixing remote spectroscopy venus
A Chemogenetic Approach for the Treatment of Atrial Fibrillation (Chem-Afib)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-05-01
End date: 2026-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Atrial fibrillation (AF) is the most common sustained arrhythmia and is responsible for significant morbidity, mortality, and burden on the health care systems. Importantly, AF events may promote further fibrillatory episodes by inducing atrial remodelling. Traditional therapies for AF have relatively limited efficacy, and are either destructive (ablation), painful (defibrillation), or associated with side effects because of their global cardiac and systemic actions (drugs). Consequentially, novel treatment modalities for AF are direly needed. Here, we propose to develop a targeted, functional, non-destructive, and easily administered treatment for AF termination that does not cause pain or other side effects, which can also potentially prevent the associated atrial remodelling. Our proposed treatment is based on chemogenetics. This approach, which transformed neuroscience, utilizes inert drugs or designer molecules that have no effect on native host cells but can modulate the electrical properties of cells that are genetically modified to express specific chemogenetic receptors. Recently, we showed the feasibility of using chemogenetic tools for modulation of cardiac excitability. Here, we aim to evaluate the potential anti-arrhythmic capabilities of our newly created chemogenetic construct, which can cause transient electrical silencing in response to an inert drug. This approach has the potential to be the first chemogenetic tool capable of “defibrillating” cardiac tissue in a highly targeted manner. To evaluate the potential of this concept for treating AF, we plan to optimize its use and study its effects in an in vitro human cardiac tissue model of reentrant arrhythmias and in an in vivo AF rodent model. The suggested approach represents a paradigm shift in the way AF can be treated and opens a pathway to targeting additional cardiac arrhythmias.
Centring Care in International Law (CAREINTLAW)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Ireland
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 1967929.0
EU funding (EUR): 1967929.0
Participants: 2
Project status: SIGNED

Feminist work in international law predominantly focuses on harm. This focus has revealed the inadequacy of much international law in capturing women’s gendered experiences of harm. Further, this work has engaged productively with legal reform opportunities to change international law in ways that better-capture gender harm. Nevertheless, there is increasingly acute feminist concern about the harm-focus for manifold reasons. Fundamentally, the focus on the individualized and episodic experiences of (gender) harm provides an inadequate basis for the sorts of structural transformation of international law that feminist work ultimately seeks. CAREINTLAW opens-up and reorients international law scholarship away from its harm focus towards the considerable though as yet unexploited resources of a focus on care. The central research question asks: How does the conceptualisation, regulation and practice of care through international legal doctrine and institutions change our understanding of international law? The question is addressed across four phases: concept refinement and theory development, by drawing on novel theoretical and methodological resources of feminist care theorisation to ask new questions of international law; generation of new and unique legal findings on the conceptualisation and regulation of care under diverse regimes of international law, through the refinement of a theoretically-informed and inductively-guided doctrinal research approach; methodological innovation in the ethnographic study of international law in order to ’surface’ care practices and their legal effects in international law-making institutions; and finally, advancing a prefigurative feminist legal methodology in order to produce international law outputs ‘as if’ care were at its centre. By centring care, this groundbreaking project will offer new ways to understand the core principles, institutions and processes of international law.

Keywords: gender,care,feminist care ethics
TOWARDS A BRIGHTER FUTURE FOR THE MEDITERRANEAN WITH A RENEWED PRIMA PARTNERSHIP (FUTURE4PRIMA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Spain,Italy,Türkiye,Jordan,Israel,Egypt,Germany,Morocco,Portugal,Croatia,Tunisia,Greece,Bulgaria,Cyprus,France,Malta
Call: Programme level collaboration between national R&I policy-makers (HORIZON-WIDERA-2023-ERA-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 2176793.25
EU funding (EUR): 2176793.25
Participants: 24
Project status: SIGNED

FUTURE4PRIMA will reinforce and enlarge collaborations between R&I national funding institutions in the fields of sustainable agri-food systems and water management in the Mediterranean, as has been done within the Horizon 2020 (H2020) Partnership for Research and Innovation in the Mediterranean Area (PRIMA), establishing a new PRIMA (“PRIMA2”). The project extends PRIMA activities across widening countries and beyond, especially towards third countries bordering the Mediterranean. It will ensure the leveraging of resources, pooled towards shared priorities addressing emerging challenges in the region and seeking complementarity with activities and policies with those of the Framework Programme and relevant European Partnerships and EU Missions. The proposal paves the way for extending the thematic focus of PRIMA to complementary fields only partially targeted in H2020 and Horizon Europe’s (HE) current and planned EU Partnerships and Missions and will add an integrated management approach of resources, including ecosystems, energy and health, to PRIMA’s original goal of sustainable water management and agri-food systems, accelerating the European Green Deal’s (EGD) objectives and globally, to the UN Agenda 2030 Sustainable Development Goals (SDGs). It will also build capacities to stimulate the uptake of R&I results aligning this process with real market and social needs. The consortium will promote relations among governments, enterprises, researchers and citizens for ensuring a sound sustainability and longevity well beyond the span of the project.

Keywords: wefe nexus,health,widening countries,international cooperation,randi priorities,sdgs,global challenges,innovation,acceleration to the market
Investigating Ortho-para coNversion of TRihydrogen cAtion in sPace (IONTRAP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-12-01
End date: 2026-10-31
Duration (months): 35.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

The simplest polyatomic molecule, trihydrogen cation, serves as a useful benchmark for fundamental quantum chemistry and has profoundly impacted astronomy. It was first detected in the interstellar medium in 1996, and has been recognized for its pivotal role as a universal proton donor and an initiator of ion-molecule chemistry producing many of the molecules detected in space. Interstellar chemistry is an exciting chemical playground of thermodynamics and kinetics as the molecules can require up to days or even weeks to reach thermal equilibrium in the low-density cold environments. A longstanding astrochemical conundrum has been the population distribution between the two nuclear spin modifications of trihydrogen cation, ortho and para, as it has important implications for its use as a cosmic ray ionization probe. In reactions involving identical particles/fermions, like trihydrogen cation, restrictions are introduced due to the Pauli principle which can significantly increase the time required to reach a thermal equilibrium. This makes the chemistry, especially the kinetics, of the ubiquitous trihydrogen cation in these regions both exciting and challenging to understand in our terrestrial laboratories. Here, I propose to use a cryogenic ion trap to isolate the nuclear spin states of trihydrogen cation which is the first of its kind for a polyatomic molecule recently developed in the host’s group. Beyond the intriguing fundamental chemical physics of this system, isolation of the nuclear spin states will be exploited to study the quantum state-specific kinetics down to 10 K for the reaction between molecular hydrogen and trihydrogen cation which is one of the most common bimolecular reactions in the universe. Performing these challenging measurements with a critical impact on our understanding of astrophysical processes will not only increase my skill set but also contribute towards my position as an emerging leader in astrochemistry.

Keywords: low temperature chemical kinetics,ion gas phase chemistry
Sulfite export mechanisms as a therapeutic vulnerability in KEAP1-deficient lung cancer (SulFex)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-10-01
End date: 2027-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Non-small cell lung cancer (NSCLC) harboring KEAP1 mutations is associated with a poor prognosis and resistance to conventional therapies. However, KEAP1/NRF2 dysregulation induces metabolic reprogramming, which can be exploited for therapeutic benefit. Our research has uncovered that these cells produce and accumulate high levels of sulfur-containing compounds, a metabolic vulnerability in these cancer cells. To maintain cellular homeostasis and survival, these cells rely on the active export of the toxic metabolite sulfite, presenting a unique therapeutic opportunity. During our ERC Consolidator project, we identified the solute carrier protein SLC26A6 as a transporter of selenite and related anions, including sulfite. We then developed SulfExstatin1, a first-in-class small molecule inhibitor that effectively inhibits human SLC26A6 and blocks sulfite export. By targeting this essential detoxification mechanism, SulfExstatin1 selectively impairs the growth and survival of KEAP1-mutant NSCLC cells while sparing normal cells, thereby minimizing off-target toxicity. Our preliminary studies demonstrate strong efficacy in cell culture, underscoring the potential of this approach as a novel treatment strategy for this aggressive cancer type. Building on these findings, we propose to establish an innovative approach targeting sulfite metabolism in KEAP1-mutant NSCLC and other cancer subtypes with similar metabolic dependencies. This project will involve optimizing SulfExstatin1 and related inhibitors, characterizing their mechanisms of action, and evaluating their efficacy in biochemical assays and in vivo models. Furthermore, we plan to establish a patent framework to protect the intellectual property arising from this project. Ultimately, our goal is to translate this metabolic-targeting strategy into clinical applications, offering new hope for patients with this treatment-resistant lung cancer.
R4R: Reproducible Data Analyses for All (R4R)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Czechia
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2024-01-01
End date: 2025-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Unevaluated science is not worth funding. Gone are the days where a scientific breakthrough could be based on scribbles made on a few loose sheets of paper reviewed by a single attentive reader. Most disciplines rely on experimental data that is collected, analyzed, and presented using powerful computational tools. The scientific adventure hinges on our ability to openly and widely share and reproduce such results. The goal of this PoC is to market a tool, R4R, for non-programmer scientists to make their archival work easily reproducible and offer it to them through a non-expensive licence. Affordable reproducibility is key to independent evaluation of previously published results. We will focus on reproducibility of data analysis pipelines written in R with RMarkdown or Jupyter. Creating a reproducible environment is hard, labor-intensive and error-prone, and requires expertise that data analysts lack. We propose to use dynamic program analysis techniques to track dependencies, data inputs, and other sources of non-determinism needed for reproducibility. R4R will synthesize metadata to generate self-contained, portable, fully reproducible environments, based on Docker images.
Partnering for the Future Hungarian EU Presidency Conference (BibeConf)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Coordination and support actions
Countries involved: Hungary
Call: Presidency event - Research and Innovation dimension of sustainable and resilient food systems (HORIZON-CL6-2024-FOOD-SYSTEMS-IBA, 2024)
Start date: 2024-10-01
End date: 2025-03-31
Duration (months): 6.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The Hungarian Presidency of the Council of the EU 2024 (Hungarian EU Presidency) aims to organize a series of discussions on research and innovation priorities in the field of bioeconomy. The series of events will commence on July 4 in Brussels and will culminate in a high-level event on December 4-6, 2024. This proposal aims to support the organization of the Presidency event in December by financing some of the costs not covered by the central budget of the Hungarian EU Presidency coordination. The high-level conference will be organized in collaboration with the European Commission and the Standing Committee on Agricultural Research under the auspices of the BIOEAST Initiative. The event is expected to attract 300-350 participants, including European Commissioners, representatives from national and EU institutions, diplomats from Member States, and policymakers from various ministries, as well as stakeholders from academia and the private sector. Additionally, EU candidate countries from the Western Balkans, Ukraine, Moldova, and Georgia will participate. The science-policy discussions at this event aim to enhance the understanding of priorities at both the Member States and European Institutions levels and will help guide the future strategic research and innovation agenda for the macro-region. The BIOEAST Initiative aims to establish a pan-European research and innovation partnership with a focus on Eastern Europe. During the Hungarian EU Presidency the initiative will center discussions on four thematic areas: healthy soils, freshwater resilience, food systems security, and modern biomanufacturing. These topics will be discussed during the high-level official Presidency event scheduled for December 4-6, 2024, Budapest, Hungary. The financial support is crucial to ensuring the event's success and facilitating comprehensive discussions and side events, including a field trip.

Keywords: hungarian eu presidency bioeast initiative