Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SEcurity REsearch NCPs network 5 (SEREN5)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Strengthened Security Research and Innovation
Action type: Coordination and support actions
Countries involved: Italy,Poland,Türkiye,Czechia,Slovakia,Israel,Greece,Cyprus,Estonia,Romania,Iceland,Belgium,Bulgaria,United Kingdom,Albania,Lithuania,Malta
Call: National Contact Points (NCPs) in the field of security and cybersecurity (HORIZON-CL3-2021-SSRI-01, 2021)
Start date: 2022-09-01
End date: 2025-12-31
Duration (months): 40.0
Total project cost (EUR): 2374666.25
EU funding (EUR): 2374666.0
Participants: 19
Project status: SIGNED

The main aim of SEREN5 is to improve and professionalise the skills of the Cluster 3 (CL3) National Contact Points (NCPs) across Europe, simplifying applicants’ access to Horizon Europe (HE) calls and raising the average quality of submitted proposals. Starting from the assumption that the NCP role is crucial in order to raise the participation in HE in terms of both quality and quantity, SEREN5 overall concept is that the CL3 NCP community requires knowledge, skills, competences and a proven comprehensive suite of tools to convey a message in a multicultural and multi-disciplinary environment such the one that characterises Cluster 3 and to effectively support its broad based constituency. Therefore, the project is based on three pillars: (i) NCPs capacity building and competence development, (ii) development of targeted and high quality services (events and tools) for CL3 applicants and stakeholders , (iii) CL3 community building and general mainstreaming of CL3 NCPs in Horizon Europe.

Keywords: national contact point,cooperation,communication,best practices,support,stakeholders,community,capacity building
Livelihoods in the Platform Economy Ecosystem (LivePlatforms)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Ireland
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Work mediated by digital platforms – where the platform brokers labour relationships between worker and client, consumer, or other end user – has become an increasing feature of the employment landscape across Europe. Consequently, understanding the nature of this work has become an urgent need. The LivePlatforms project will develop and test a method for gathering qualitative data on the wide ecosystem that comprises platform work as a lived experience across a national context and critically appraise the mediating roles of the actors involved in this economy. The over-arching aim of this project is to develop a holistic understanding of platform labour by generating, applying, and evaluating a methodological framework that will enable the interrogation of the forces comprising the experience of this work, including and especially those of the lifeworld. By combining methodological concepts from Social Reproduction Theory, Actor Network Theory, and the Livelihoods Approach, it proposes the Platform Livelihoods Ecosystem Approach (PLEA). This methodology approaches platform work as an ecosystem of interacting actors, systems, and processes that manifest across a broad range of labour forms and which interconnect in the pursuit of a livelihood by workers. The objectives are to develop, test, and evaluate this method; to generate a complex understanding of the actors, systems, and processes that define a national platform economy and how they interact to produce labour outcomes; and to critically assess the mediating agency of these actors. The outcomes will be a rich, critical, empirical understanding of the lived experience of platform work and a tested method for qualitatively evaluating platform work on a national scale and with the necessary scope for holistic understanding. This method will provide the research underpinnings for further projects supporting the development of fair, secure, and decent work in this growing sector.

Keywords: digital platforms labour studies digital media platform studies
Disrupting X-ray and Short-Wave Infrared Imaging Technology with Quantum Dots (QDIMAGING)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 3570875.0
EU funding (EUR): 2499612.5
Participants: 1
Project status: SIGNED

Medical and consumer imaging face substantial challenges. The highest-resolution Xray detectors use >15-year-old technology, with inadequate image quality yielding unacceptable false negative/positive rates in mammography, especially in dense breast tissue. Meanwhile, short-wave infrared (SWIR) imaging has great commercial potential, but sensors are plagued by high cost and low scalability. QDI has a breakthrough solution to both: our unique, patented process of synthesizing PbS quantum dots of varying sizes into “ink” coatings enables revolutionary X-ray and SWIR imagers. X-ray sensors can reach 5x higher sensitivity than amorphous selenium at low dosage, with >80% high-energy absorption for contrast-enhanced mammography, greatly exceeding current detectors. SWIR sensors can be produced with exceptional speed at low cost, granting novel capabilities to device designers. With EIC support, QDI will transform medical and commercial markets, becoming a European world imaging leader.

Keywords: quantum dots,quantum dot inks,semiconductor imaging devices,x ray detectors,short wave infrared sensors
Trouble in the air: How European forests keep their cool under atmospheric drought (COOL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Countries involved: Switzerland
Call: ERC CONSOLIDATOR GRANTS (ERC-2025-COG, 2025)
Start date: 2026-06-01
End date: 2031-05-31
Duration (months): 60.0
Total project cost (EUR): 1997365.0
EU funding (EUR): 1997365.0
Participants: 1
Project status: SIGNED

The 21st century has witnessed a steady rise in the frequency and intensity of heatwaves, creating unprecedented challenges for ecosystems. Europe, in particular, has experienced its hottest heatwaves in the past two decades, increasingly coupled with elevated vapor pressure deficit (VPD)—the atmospheric demand for water—resulting in a new form of “atmospheric droughts.” These droughts disrupt plant water relations, diminish carbon sink capacity, and trigger large-scale tree mortality. Our overarching goal is to unravel how European forests respond to rising VPD and temperature, their extremes, and compounding soil drought effects. COOL integrates innovative methodologies, including state-of-the-art laboratory experiments, the first-ever VPD manipulation in a natural forest, a pan-European monitoring network, and advancements in mechanistic modeling. We will (1) systematically assess what drives trees’ thermal and VPD tolerance, an area previously unexplored but crucial for predicting forest resilience; (2) disentangle, for the first time, the impacts of temperature, VPD, and soil moisture in natural settings—an achievement made possible by novel methodological developments; (3) investigate the role of long-term acclimation to temperature and VPD under varying soil moisture scenarios, leveraging unprecedented experimental infrastructure; and (4) quantify the consequences for forest growth, water use, and tree mortality. By combining cutting-edge approaches to collect high-resolution hydraulic and thermal data, COOL overcomes a critical bottleneck in forest research. The project will deliver groundbreaking insights into forest resilience under future climates. These results will advance climate-smart forest management, inform policy frameworks, equip stakeholders with actionable tools, and foster education in global change ecology. COOL will establish new paradigms for predicting and mitigating the long-term consequences of atmospheric droughts on forest ecosystems.

Keywords: tree physiology,drought,heat,vapor pressure deficit,plant hydraulics,plant thermal tolerance
Disease-Modifying RNA Therapy to Cure Epilepsy (CUREP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The ambition of the CUREP EIC Accelerator project is to develop the worlds first blockbuster drug for disease-modification of epilepsy. More than 50M people worldwide live with epilepsy and there are currently no disease-modifying drugs for epilepsy. This means that patients are provided with drugs that treat symptoms rather than the disease itself. Importantly, over one third of patients become resistant to the current therapies and continue to suffer from uncontrolled or partially controlled seizures, highlighting the huge unmet medical need in society. We have completed preclinical Proof-of-Concept studies of our lead RNA-based candidate, NMT.001, which has achieved unprecedented efficacy and disease reversal in a validated model of drug-resistant epilepsy. We have achieved 67% seizure freedom beyond drug exposure and 74% reduced risk of death in mice. Also, we have confirmed no liver tox based on plasma ALT and AST levels in NMT.001 treated mice. Such preclinical results have not been previously introduced in the world. In this EIC Accelerator project we will: 1) Translate our production from preclinical to clinical 2) Establish a clinical infrastructure 3) Initiate Phase I/IIa clinical studies with NMT.001 NMT has prior to EIC Accelerator raised EUR 5.6M in investments and is preparing a Series A financing round of EUR 30M+. Sunstone Life Science Ventures (DK) and Innovestor Life Science Fund (FI) are current NMT-investors. Innovestor is lead Series A partner. The Series A financing round provides an excellent timing and springboard for EIC blended finance. The grant part will pave the way to first-in-human trials, while an accompanying EIC investment will be pivotal for the transformation of NMT into a global frontrunner within epilepsy and creating a better Quality of Life for individuals suffering from epilepsy.

Keywords: disease modification,rna therapy,epilepsy cure,paradigm shift,blockbuster treatment
Exploring inflammasome activation and targeted inhibition (NalpACT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2155047.0
EU funding (EUR): 2155047.0
Participants: 1
Project status: SIGNED

Inflammasomes are cytosolic multi-protein complexes that form in response to a wide range of pathogens, tissue damage, and other harmful stimuli. Members of the family of NOD-like receptors (NLRs) sense these pathogen and danger associated molecular patterns, triggering innate immune responses. NLRP3 is a well-studied NLR whose activation by a broad spectrum of stimuli leads to inflammasome formation and pyroptosis. Yet, the mechanisms inducing NLRP3 activation and the way how antagonistic small molecules counteract its function remain poorly understood. Just recently, we have determined the cryo-electron microscopy structures of full-length human NLRP3 in its inactive form and bound to the inhibitor CRID3. Native NLRP3 is a decamer composed of homodimers of intertwined LRR domains that assemble back-to-back as pentamers. We made the surprising finding that the effector pyrin domain is shielded inside the decamer cage providing a safeguard mechanism against accidental activation. To obtain insights into the activation mechanism of NLRP3 and the molecular formation of the inflammasome, I here propose a challenging and pioneering endeavour: employing biochemical, biophysical and structural analyses, we will resolve the structure of activated NLRP3 associated to lipid membranes, unravel its regulation by post-translational modifications, design specific inhibitors for the targeted protein degradation, and explore filamentous seeds for the maturation of Caspase-1 and Alzheimer’s disease forming amyloid-beta fibrils. Further, transferring our knowledge of CRID3-mediated NLRP3 inhibition to other NLRs as NLRP12 and NLRP1 will shed light on their mechanism of action and open new avenues for directed targeting. Collectively, this work will uncover fundamental molecular principles of inflammasome activation and the mode of action of anti-inflammatory drugs. I foresee, that these insights will open a wide field for the development of NLR-specific inhibitors as new medicines.

Keywords: inflammasome,cryo em,nod like receptor,nlrp3,protein inhibition
CoprodAction: Addressing the coproduction of urban environment in Quito, Ecuador (CoprodAction)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

CoprodAction addresses the problem of societal restructurings stemming from rapidly advancing climate change in combination with the current COVID-19 pandemic that has triggered major additional challenges in cities across the Globe, and especially in Global South. The case of Quito reveals both critical encounters of these multidimensional problems and also community-based innovative experiments that have achieved coproduction of more sustainable and resilient urban environments. The main objective of CoprodAction is to understand to what extent the application of community-led practices influences or contributes to improving the coproduction of such environments, affecting the effectiveness of urban planning and social equality. To this end, CoprodAction will employ both quali-quantitative and socio-spatial approaches. Therefore, the research will be developed through theoretical research about practices and concepts, including the comparison between conceptualization and application of co-producing urban environments. Further, the empirical research includes both traditional spatial analysis, ethnographic analysis and collaborative analysis, such as co-mapping and permanent coproduction laboratory with local actors as civic organizations, NGOs, municipal authorities, urban planners and other relevant stakeholders. The project will provide in-depth understanding on how such alternative knowledge may inform and contribute to the elaboration and implementation of novel approaches for the governance of contested urban territories, with transferable results to other geographical contexts in cities across Latin America and Global South. Finally, it defines a new and broader conceptual framework of coproduction, and also processes and mechanisms preparatory to the success of coproduction. Further, it presents a co-designed proposal for updating and adapting the planning and transformation model of the resilient, sustainable and equity-oriented urban environment.

Keywords: urban governance,coproduction,participatory methods,global south,latin america,ecuador
Targeting epigenetic regulators during leukemia evolution (EpiTransformers)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 1495188.0
EU funding (EUR): 1495188.0
Participants: 1
Project status: SIGNED

A major gap in knowledge exists relating to the mechanisms via which a normal hematopoietic stem cell attains a fully transformed state via preleukemic intermediates. It is now accepted that a key player in this transition is epigenetic plasticity. Identifying the epigenetic mechanisms regulating the transformation of normal to leukemic stem cells will open new avenues for the identification of therapeutics at different stages of disease. A characteristic stem cell-like gene expression pattern is a hallmark of aggressive acute myeloid leukemia. Intriguingly, most of these patients harbour mutations in epigenetic modifiers that directly regulate stemness. What is fundamentally missing is a comprehensive understanding of which chromatin factors are involved in maintaining normal stem cell programs and how they are modulated during leukemic transformation. I recently uncovered a novel epigenetic mechanism of transition to the leukemic-state, mediated by direct chromatin binding of mutant NPM1 and transcriptional regulation of a specific set of stem-cell genes. This discovery, together with cutting-edge ultra-low-input chromatin technologies and our recently developed in vivo models of preleukemia, will serve as the springboard to address these fundamental questions: 1) How are normal hematopoietic stem cell programs regulated at the epigenetic level? 2) What are the epigenetic landscape alterations that govern tumorigenicity? 3) How can we exploit epigenetic dependencies to pharmacologically target the premalignant and/or malignant state? EpiTransformers will delve into the largely unexplored epigenome during the leukemic transformation of rare stem cell populations using cutting-edge epigenetic profiling technologies and sophisticated in vivo models to deconvolute different steps of leukemogenesis and identify cancer specific vulnerabilities. The goal of EpiTransformers is to develop new therapeutic approaches by specific targeting of premalignant leukemic states.

Keywords: epigenetics,preleukemia,preventation
Aligning Brain Rhythms: Understanding the mechanisms of cortical tracking of speech to improve language functions with real time closed-loop neurofeedback (CORTICAL RHYTHMS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Spain
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Speech processing and reading are essential unique human abilities underpinning social, educational, and professional advancement. However early biomarkers for learning disabilities such as Developmental Dyslexia (DD) and for second language learning have yet to be identified. Here, cutting edge neuroimaging tools, carefully designed tasks, and longitudinal designs will be used to record cortical tracking of speech (CTS), namely, the temporal alignment between fluctuations in the speech signal and fluctuations in electrical brain activity across different populations. Specifically, we will investigate the predictive ability and causality of CTS 1) at an early age in language development, 2) for second language learning, reading, DD and illiteracy, 3) establish the domain-specificity of CTS as ‘biomarker of language processing’, and 4) pioneer a real-time closed-loop neurofeedback protocol modulating CTS to adaptively change language processing and learning through neurofeedback. This project represents a radically new scientific approach that will break new ground by investigating the predictive ability of CTS that combined with longitudinal designs and real-time closed-loop neurofeedback will allow us to (1) establish causal relationships and (2) use this novel approach to improve L2 learning and to diagnose and remediate DD.

Keywords: language oscillatory activity cognitive psychology developmental dyslexia literacy brain stimulation brain plasticity sign language visual attention language rhythms cognitive neuroscience longitudinal designs neurofeedback closed loop eeg meg mri