Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecular mechanisms of bacterial invasion and colonization in the human gut microbiota (MICROINVADER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

The human gut microbiota plays a critical role in safeguarding human health by defending against pathogens and supporting essential metabolic and immune functions. Nevertheless, our understanding of how the gut microbiota influences bacterial invasion and evolution within the human body is incomplete due to the complexity of these interactions. Furthermore, the specific mechanisms through which commensal bacteria, such as Escherichia coli, successfully invade and evolve in distinct human gut microbiota compositions remain unclear. The MICROINVADER project aims to address this knowledge gap, utilizing an established in vitro gut simulator to investigate the precise mechanisms underlying the successful invasion of distinct human gut microbiota ecosystems by the commensal bacterium E. coli. Furthermore, MICROINVADER aims to characterize at the molecular level the processes that shape the evolution of invading strains in response to specific human gut microbiota compositions. Subsequently, MICROINVADER will validate these findings through in vitro and in vivo experiments, focusing on quantifying the selection strength acting on the genetic mechanisms that are crucial for bacterial invasion and colonization in different human gut environments. By unveiling these novel mechanisms driving bacterial invasion and colonization within diverse human gut microbiotas, MICROINVADER seeks to provide critical insights that may have far-reaching implications for enhancing human health. Ultimately, MICROINVADER aims to contribute to our understanding of how to manipulate the gut microbiota in ways that promote and sustain overall well-being.

Keywords: colonization resistance intrahost evolution e coli human microbiome experimental evolution
Dynamics of nano-electromechanical waveguides: A computational multi-physics framework (NANOWAVE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-10-31
Duration (months): 29.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

The remarkable electrical and mechanical properties of heterogeneous nano waveguides make it a promising material for nano-electromechanical devices such as resonators constructed by nanotube and graphene. The investigation of heterogeneous nano waveguides can advance the development of the existing energy and wave controlling systems, thereby contributing significantly to the exertion of device performance and the reduction of energy consumption. However, the integration of nano waveguides into functional architectures requires the development of advanced manufacturing approaches, which leads to a significant increase of research costs. Here, we present a novel perspective on dynamic analysis of heterogeneous nano-electromechanical waveguides through a computational multi-physics framework, which is based on the homogenization approach equipped with second strain gradient theory. This research project will extend the homogenization techniques used in simple waveguides to the heterogeneous nano waveguides and provide a way to considerably reduce the computational effort. On the other hand, this research project will give new insights on the size-dependent characteristics and enrich the explorations of dynamic properties for nano-electromechanical waveguides. This project will be carried out by a talented and dedicated researcher who worked during his Ph.D. thesis on wave computational simulation method of heterogeneous nano waveguides through second strain gradient theory. The researcher will collaborate with a supervisor who has a very strong background in homogenization approach and in correspondences between second strain gradient theory and programming languages. Working in Sweden, where homogenization of nano waveguides is a subject of intense research by many experts in the field, the researcher will benefit from his experiences in France and Italy, which have strong communities on second strain gradient theory and wave computational simulation method.

Keywords: numerical simulation,dynamic properties,nano materials,electromechanical waveguides
Human-Compatible Artificial Intelligence with Guarantees (AutoFair)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Czechia,Greece,Ireland,Israel,United Kingdom
Call: Verifiable robustness, energy efficiency and transparency for Trustworthy AI: Scientific excellence boosting industrial competitiveness (AI, Data and Robotics Partnership) (RIA) (HORIZON-CL4-2021-HUMAN-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 3350720.0
EU funding (EUR): 3350720.0
Participants: 8
Project status: SIGNED

In this proposal, we address the matter of transparency and explainability of AI using approaches inspired by control theory. Notably, we consider a comprehensive and flexible certification of properties of AI pipelines, certain closed-loops and more complicated interconnections. At one extreme, one could consider risk averse a priori guarantees via hard constraints on certain bias measures in the training process. At the other extreme, one could consider nuanced communication of the exact tradeoffs involved in AI pipeline choices and their effect on industrial and bias outcomes, post hoc. Both extremes offer little in terms of optimizing the pipeline and inflexibility in explaining the pipeline’s fairness-related qualities. Seeking the middle-ground, we suggest a priori certification of fairness-related qualities in AI pipelines via modular compositions of pre-processing, training, inference, and post-processing steps with certain properties. Furthermore, we present an extensive programme in explainability of fairness-related qualities. We seek to inform both the developer and the user thoroughly in regards to the possible algorithmic choices and their expected effects. Overall, this will effectively support the development of AI pipelines with guaranteed levels of performance, explained clearly. Three use cases (in Human Resources automation, Financial Technology, and Advertising) will be used to assess the effectiveness of our approaches.

Keywords: fairness,transparency,explainability,control theory
Electrochemically Driven Organocatalytic Transformations of Alcohols, Thiols and Disulfides (ECOT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-12-01
End date: 2029-11-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The purpose of this research, set in the context of synthetic organic chemistry, is to develop unprecedented methods for electrochemically driven cleavage and subsequent functionalization of C–O and C–S bonds in alcohols, thiols and disulfides using organocatalysts based on phosphorus and sulfur. These radical methods will serve as keys to unlock the potential of the targeted compound classes as feedstocks for synthesis of functional organic compounds, e.g., pharmaceuticals, as well as for biomass valorization processes. Due to the complexity of the targeted transformations, the scarcity of available methods and the novelty of the outlined approach, the research will expand the synthetic toolbox, enable new retrosynthetic disconnections and late-stage (de)functionalization of, e.g., carbohydrates and peptides. Combined with the integrated mechanistic studies, the research will have a significant impact from a fundamental science perspective, as well as enable new synthetic applications. The project is divided into two main topics, each sized for one PhD student and one postdoc working together on the outlined work packages. The proposed research is supported by preliminary results that indicate its viability.

Keywords: electrosynthesis,organosulfur compounds,catalysis,c centered radicals,cross coupling
EXPRESS 2 SPECIFY AND PROTECT THE EU SOCIAL CONTRACT (EXPRESS2) (Express2)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Spain,Denmark,Italy,Norway,Türkiye,Belgium,Ireland,United Kingdom,Austria
Call: Democratic governance for times of disruptive changes to the social contract (HORIZON-CL2-2023-DEMOCRACY-01, 2023)
Start date: 2024-03-01
End date: 2027-02-28
Duration (months): 36.0
Total project cost (EUR): 2795851.25
EU funding (EUR): 2795851.25
Participants: 12
Project status: SIGNED

EXPRESS2 is a project that addresses from a multidisciplinary, interdisciplinary and cross-sectional perspective, the growing demand for a new, more democratic, inclusive, and sustainable social contract in the EU. To achieve this, the project will work to create a more appealing and legitimate EU social contract draft that will be submitted to inhabitants, Member States and EU institutions that will have the possibility to participate and decide upon the conditions, rights, and obligations to be binding. The goal is to strengthen the EU agreement of association by promoting social dialogue, civic engagement, and integration. An express draft shall be achieved by means of policy dialogue, campaign implementation, collaborative workshops, advocacy planning, and innovative offline and online formats and tools to create spaces for dialogue. To this end, EXPRESS2 will involve EU policymakers and institutions throughout the project to obtain a more appealing and legitimate EU social contract draft. The project will also focus on identifying and analyzing disruptive elements of the social contract, such as insecurity, populism, climate change, mistrust in institutions, gender discrimination, digitalisation and pandemics. The analysis of these stressors includes both individualised and cross-sectional approaches to cover the plausible relation of multiple disruptors, their concatenation or the “trigger” effect of a disruptive phenomenon to another. By understanding these disruptive elements and their effects on the social contract, the project will propose concrete measures to ironclad the social contract and it will provide relevant information to protect it from actual and potential disruptions thus we conceive social contracts as incomplete theorised agreements and living documents. In addition to academic, policy, and socio-economic outcomes, EXPRESS2 will propose recommendations to strengthen the social contract's resilience and capacity for further development.

Keywords: deliberative and participative democracy political inclusion protection of the eu founding values and principles political contractualism,consent stability and disruption
HYdrogel-based Matrices for Advanced Tissue Engineering (HYMATE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-12-01
End date: 2027-05-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Tissue decellularization is a well-established technique in tissue engineering to preserve the biochemical complexity of native tissues. However, its application in recreating the tumor stroma for in vitro studies remains limited, with current models often relying on non-specific extracellular matrices that lack the unique characteristics of the tumor microenvironment. Here, we present a novel technology to develop hydrogels from decellularized tumor tissue using a tumor cell culture-derived matrix. This new technology, developed as part of the ERC project ICoMICS, improves the preservation of the composition of the matrix, in contrast to currently available alternatives. Hence, this technology creates a market opportunity to improve the development of hydrogels not only for cancer modeling, but also for a wide range of potential applications in disease modeling and regenerative medicine. In addition, by leveraging our extensive expertise in hydrogel characterization, we will expand our products not only for the production of specific hydrogels, but also for the characterization of all types of hydrogels according to the specific needs of potential users. Therefore, the main objective of this proof of concept is to assess the potential of this project to evolve into a spin-off company focused on: 1) commercializing novel hydrogels for tumor and disease modeling, and 2) providing potential customers with a wide range of accessible and thorough characterization methods. In addition, we aim to assess the market opportunities for both the commercialization of our hydrogel products and the establishment of a specialized characterization service providing in-depth physicochemical analysis of biomaterials for research groups and industry stakeholders.
First in class lateral meniscus prothesis to relieve pain and restore mobility for KOA patients (AL U KNEED)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-04-01
End date: 2026-03-31
Duration (months): 36.0
Total project cost (EUR): 3570575.0
EU funding (EUR): 2499402.5
Participants: 1
Project status: SIGNED

ATRO Medical developed a revolutionary prothesis that quickly relieves pain and restores mobility for severe KOA patients with a dysfunctional lateral meniscus: Trammpolin. We offer a minimally invasive, low impact procedure that postpones undesirable TKR and reduces KOA-related healthcare costs and medication dependency, while restoring full knee functioning. Our innovation is composed of a dual highly biocompatible polymer that carries the body weight and is uniquely shaped to reproduce the anatomical shape and mechanical properties of the native meniscus. The technology has proven itself for the medial meniscus and received the Breakthrough Device Designation of the US FDA in 2020. For successful market entry of our lateral Trammpolin in 2026, we aim to finalize our pre-clinical activities, conduct a FIH-study, and obtain CE-marking. In parallel we will perform a health economics analysis as a crucial step towards obtaining reimbursement for large scale uptake in the medical system.

Keywords: highly compatible polymer,native meniscus implant
Global Estimates for non-linear stochastic PDEs (GE4SPDE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1948233.0
EU funding (EUR): 1948233.0
Participants: 1
Project status: SIGNED

The project is concerned with the global behaviour of solutions to Stochastic Partial Differential Equations (SPDEs) from Mathematical Physics which arise e.g. in the description of scaling limits of interacting particle systems and in the analysis of Quantum Field Theories. The equations contain noise terms which describe random fluctuations and act on all length scales. In this situation the presence of a non-linear term can lead to divergencies. A subtle renormalisation procedure, which amounts to removing infinite terms, is needed. Over the last years the understanding of non-linear SPDEs has been revolutionised and a systematic treatment of the renormalisation procedure has been achieved. This led to a short-time well-posedness theory on compact domains for a large class of highly relevant semi-linear SPDEs. In this project, I will describe the global - both in time and over infinite domains - behaviour of solutions of some of the most prominent examples, by combining PDE techniques for the non-linear equations without noise and the improved understanding of the subtle small-scale stochastic cancellations. I have already pioneered such a programme in an important special case, the dynamic Phi-4 model. The project has three specific strands: A) Proving estimates for the stochastic quantisation equations of the Sine-Gordon and Liouville Quantum Gravity models and eventually Gauge theories, and to giving a PDE-based approach to the celebrated 1-2-3 scaling of the KPZ equation, B) giving PDE-based constructions of Phi-4 models in fractional dimension and describing phase transitions in terms of mixing properties of the dynamics, C) treating degenerate parabolic equations and exploring if systems that fail to satisfy a fundamental "sub-criticality" scaling assumption can still be treated using SPDE techniques.

Keywords: stochastic partial differential equations,regularity structures,a priori estimates,phase transitions,stochastic quantisation
Enhancing the Scientific Excellence of TUBITAK MRC MT in Ceramic Membrane Fabrication for Industrial Wastewater Recovery Applications via Knowledge Transfer and Capacity Building (Twin-CeraMem)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Chemistry
Countries involved: Türkiye,Belgium,Germany
Call: Twinning Green Deal (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 1478222.1
EU funding (EUR): 1478222.1
Participants: 3
Project status: SIGNED

Due to rising water demand and an increased focus on sustainability, ceramic membranes, known for their superior chemical and thermal resistance, are becoming increasingly important in recovering industrial wastewater. With a CAGR of 11.9%, the European ceramic membrane market is anticipated to reach 3.5 billion US dollars by 2030. The number of projects and R&D studies on ceramic membranes in Turkey is quite limited; there is not yet sufficient awareness about the necessity of ceramic membranes in the industry, and commercial production of ceramic membranes cannot yet be carried out. TÜBİTAK Marmara Research Center (MRC) is Turkey's leading research center producing science and technology with its research, development, and innovation capabilities. Material Technologies Vice Presidency (MT) of TÜBTAK MRC, with its interdisciplinary knowledge and human capacity in both ceramic and sol-gel technologies, can fabricate and characterize MF, UF, and NF tubular ceramic membranes on a laboratory scale. However, it has challenges regarding ceramic membrane substrate fabrication, scaling up, and ceramic membrane layer modification, limiting the real-life industrial usage for wastewater recovery. The Twin-CeraMem aims to meet the requirements of the HORIZON-WIDERA-2023-ACCESS-02-02 Twinning Green Deal Call. The main objective of this project is to increase the scientific, innovative, and administrative excellence capacity of TUBITAK MRC in the field of ceramic membrane fabrication for industrial wastewater recovery applications in order to support the sustainable use of water as a natural resource. This main goal is to be achieved with the support and mentoring of leading European partners Fraunhofer IKTS (Germany), which specializes in ceramic membrane substrate fabrication, and VITO NV (Belgium), which specializes in selective separation membrane layer modification.

Keywords: ceramic membrane,industrial wastewater,modification,nanofiltration
Advancing Research & Innovation of FORTH in Green Soft Matter (FORGREENSOFT)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Greece,Austria,Germany
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2022-12-01
End date: 2025-11-30
Duration (months): 36.0
Total project cost (EUR): 1489500.0
EU funding (EUR): 1489500.0
Participants: 4
Project status: SIGNED

A broad range of widely used industrial products, consist of complex Soft Matter systems (polymers, colloids, emulsions, etc.) made-up of synthetic ingredients of high environmental footprint. Urgent societal needs, embodied in the European Green Deal, require the replacement of synthetic components by Green, environmentally-friendly counterparts. The transition to Green materials is of vital importance for the transformation towards a sustainable eco-friendly production and a highly needed circular economy and sustainable growth. FORGREENSOFT aims at advancing the Research Capacity of FORTH in the area of Green, bio-based soft materials by transferring knowledge from three world-leading Institutions in the field of Green Chemistry (Max Planck of Colloids and Interfaces) as well as in specific experimental and computational methods (Max Planck for Polymer Research and University of Vienna). The later are vital in a leading research activity in Green Soft matter, but are lacking in the Host Institute. FORGREENSOFT research objectives will be achieved by a well-balanced training and personnel exchange program as well as a collaborative research program focusing on two key applications: Green antifouling coatings and water desalination membranes. In parallel, FORGREENSOFT aims at enhancing the networking activities of FORTH and improving its capacity to successfully participate in a wider range of EU calls, to attract industrial funding, and to promote innovation. These objectives will be reached by transferring expertise from the leading partners, via the training of FORTH’s personnel in soft skills, and by local restructuring measures such as the creation of an Industry-Academia Liaison office focused on Green Soft Matter applications. Moreover, the leading partners will benefit by establishing new scientific collaborations with FORTH on promising research directions, and by extending their expertise in fields, in which FORTH has an established research record.

Keywords: green soft matter,afm,optical microscopy,computer simulations