Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Miniaturised photoacoustic gas sensor based on patented interferometric readout and novel photonic integration technologies (MINIGAS)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Components, systems, engineering
Action type: Collaborative project
Countries involved: Finland,United Kingdom,Russian Federation,Italy,Romania,Norway,Germany
Call:  (FP7-ICT-2007-2, 2007)
Start date: 2008-04-01
End date: 2012-09-30
Duration (months): 54.0
Total project cost (EUR): 2549342.0
EU funding (EUR): 1850000.0
Participants: 9
Project status: CLOSED

High-sensitivity gas sensors measure the presence of trace gases. They have a wide range of applications. Finnish SME Gasera has recently developed a MEMS-based mechanism for detecting the pressure waves created in photo-acoustic cells. This innovation can be used to realize infrared gas sensors of extreme sensitivity. Instead of the usual microphone (membrane with capacitive readout) the Gasera cell contains a “free-standing” silicon cantilever. The mechanical movement of the free end of the cantilever is 100x larger than the centre of a fixed membrane. Furthermore, the movement of the cantilever is detected interferometrically not capacitively. The resulting improvement in sensitivity by these innovations is about three orders of magnitude over the prior art. Three international patent applications are pending. Whereas other optical gas detection methods can not be miniaturized because of the long optical pathlengths needed for high sensitivity, theoretical analyses predict that the cantilever PA cell can be miniaturized. The goal is to build and demonstrate a miniaturised sensor sub-system that achieves two or three orders of magnitude better sensitivity (on sub-ppm level!) than other optical measurement methods could achieve at similar package volume. A much lower cost and wider temperature range of operation are also predicted. Keywords photo-acoustic, gas detection; high sensitivity; cantilever interferometric readout

Keywords: photo-acoustic,gas detection,high sensitivity,interferometric cantilever readout,miniaturized photoacoustic cell
Smart Houses Interacting with Smart Grids to achieve next-generation energy efficiency and sustainability (SMARTHOUSE/SMARTGRID)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: ICT for mobility, environmental sustainability and energy efficiency
Action type: Collaborative project
Countries involved: Germany,Germany,Germany,Netherlands,Greece,Netherlands
Call:  (FP7-ICT-2007-2, 2007)
Start date: 2008-09-01
End date: 2011-08-31
Duration (months): 36.0
Total project cost (EUR): 3801284.0
EU funding (EUR): 2548141.0
Participants: 8
Project status: CLOSED

Current smart house/energy technologies treat home and working environments as effectively consisting of isolated and passive individual units. This severely limits achieved energy efficiency, as it ignores the potential delivered by homes, offices, and commercial buildings seen as intelligent networked collaborations. Thus, the SmartHouse/SmartGrid project introduces a holistic concept for smart houses situated and intelligently managed within their broader environment. It develops intelligent networked ICT technology for collaborative technical-commercial aggregations of Smart Houses able to communicate, interact and negotiate with both customers and energy devices in the local energy grid so as to achieve maximum overall energy efficiency as a whole. Our technology is built on (i) using available open industry standards in both the ICT and energy sectors; (ii) employing communication and computing capabilities that are already in widespread use in mainstream home and working environments. The SmartHouse/SmartGrid technology will be field tested in three different countries. On this basis, the project will define a roadmap to mass application. Only by considering the aggregated network level of smart houses managed by intelligent networked ICT for scale and flexibility, one is able to achieve the quantum leap in energy efficiency and sustainability that the EU’s “20% by 2020” objectives call for.

Keywords: intelligent houses,grid integration,commercial aggregation,ict scalability,interoperability
Virtual Pathological Heart of the Virtual Physiological Human (VPH2)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Towards sustainable and personalised healthcare
Action type: Collaborative project
Countries involved: Germany,Switzerland,United Kingdom,Greece,Italy,United Kingdom,Sweden,Poland,Germany
Call:  (FP7-ICT-2007-2, 2007)
Start date: 2008-07-01
End date: 2011-10-31
Duration (months): 40.0
Total project cost (EUR): 5624244.0
EU funding (EUR): 3118124.0
Participants: 17
Project status: CLOSED

Heart failure accounts for almost a quarter of all admissions to hospital for cardiovascular events, has a high mortality (median survival around 18 months), and places a great burden on all healthcare systems, with estimated direct costs of £905m (?1350m) in the United Kingdom in 2000, 2% of total NHS expenditure. VPH2 aims to develop a patient-specific computational modelling and simulation of the human heart to assist the cardiologist and the cardiac surgeon in defining the severity and extent of disease in patients with post-ischemic Left Ventricular Dysfunction (LVD), with or without ischemic mitral regurgitation (IMR). Specific computational methods will allow clinical decision making and planning of the optimal treatment for left ventricle-valve repair. The goal is not only to deploy a fully validated technology to partner clinical institutions, but also to develop a sustainable business model associated to it. The associated technological aim of the project is to deliver the most advanced software application framework for the development of computer-aided medicine in cardiology and cardiac surgery available in the world, going beyond the state of the art of available models. This goal will be achieved by integrating some of the leading Open Source software in the area of computer-aided medicine and of computational bioengineering. This framework will be used by VPH2 to realise its objectives, but also by any other future project (academic or industrial) aiming to improve or extend VPH2 objectives.

Keywords: heart failure,treatment for left ventricle-valve,cardiac surgery
EFFECT OF AEROSOL PARTICLES ON AIR QUALITY AND CLIMATE CHANGE (EFAPAC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-08-01
End date: 2012-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Health effects due to air pollution and the potential detrimental effects of climate change are among the most important current environment-related problems. Quantifying the effect of aerosols on the planet’s radiative balance is one of the most urgent tasks in our efforts to understand future climate change. The contributions of the various aerosol sources, the role of long-range transport, and the contribution of primary and secondary particulate matter to the ambient aerosol concentrations over Europe are still largely unknown. The proposed work has two objectives: (i) Reduction of the current uncertainty of the impact of aerosol particles on climate and quantification of the relationship between anthropogenic aerosol and regional air quality. To achieve this objective, the proposed work will concentrate on the areas of greatest uncertainties. We will identify and quantify the processes and sources governing global and regional aerosol concentrations, and quantify the feedback processes that link climate change and atmospheric aerosol concentrations with emphasis on the production and loading of natural aerosols and their precursors; (ii) Development and application of a fundamental capability to simulate the indirect climatic effect of aerosols in climate models, based on integration of size-resolved treatment of tropospheric aerosols and explicit aerosol-cloud microphysics into a Global Climate Model. The proposed work will produce advanced aerosol and cloud models that can be used by global and regional climate and air quality modeling scientific communities. (i) will be achieved by improving our understanding of atmospheric aerosol physics and chemistry, which, in turn, will enhance our ability to forecast short-term regional air quality, as well as to estimate the long-term aerosol effects on the current and future global climate. (ii) will help better assess future climate change.

Keywords: climate change,air quality,aerosol,global climate model,atmosphere,troposphere,chemistry,aerosol number,cloud,droplet,global warming,cooling,radiative forcing,temperature
Molecular Mechanisms in Diabetic Embryopathy (DIABETIC EMBRYOPATHY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Czechia
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-09-01
End date: 2012-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The main objectives of the proposed reintegration research grant are: 1) to investigate the molecular causes of diabetic embryopathy; 2) to transfer my knowledge and experience to the Czech and European academia and industry; and 3) to develop a network of future international research collaboration dealing with diabetes. The scientific objective is to understand how maternal diabetes affects the developing embryo and increases the risk for heart malformations. The risk for birth defects is up to 10-fold higher in diabetic than in non-diabetic pregnancies. With increasing prevalence of diabetes in women of childbearing age, diabetes becomes a major cause of mortality and health problems in infants born to diabetic mothers. Although the teratogenic effects of maternal diabetes are well documented, the molecular causes remain elusive. Using global expression profiling, our team discovered that the exposure to maternal diabetes deregulated 126 genes in developing embryos. Many of these genes are already known to be involved in heart defects or affect heart functions. In this project I propose: 1) to define which genes can serve as predictive markers for specific abnormalities in heart development; 2) to determine cell-type specificity of diabetes-deregulated genes within the developing heart; 3) to identify specific time points, which are the most susceptible for induction of changes in the heart; and 4) to investigate the role of HIF1-controlled-hypoxia-response pathways in diabetic embryopathy. Understanding the molecular causes of diabetic embryopathy will form the basis for future strategies to prevent birth defects associated with diabetic pregnancies. The reintegration objectives will be achieved via my appointment as an independent Group Leader at the Institute of Molecular Genetics of the Academy of Sciences of the Czech Republic, where I will be responsible for team building, training, teaching, and conducting high quality collaborative research.

Keywords: diabetes,diabetic pregnancy,embryonic development,congenital malformations,gene expression,hypoxia-inducible factor 1 pathways,quantitative rt-pcr,heart defects
Twistor methods for Quantum Field Theory (TMQFT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2008-03-01
End date: 2010-03-26
Duration (months): 24.0
Total project cost (EUR): 30000.0
EU funding (EUR): 30000.0
Participants: 1
Project status: CLOSED

This project concerns the further development and exploration of new calculational technology for quantum field theory in mainly four dimensions based on the mathematics of its associated twistor space. The applicant was involved in some promising initial steps in this direction initiated in Oxford. As quantum field theory is a 'language' which has an extremely wide range of applications, this technology has the potential of having an impact in several areas of physics and mathematics. Three broad directions within high energy physics are singled out in the proposal: - Streamlined perturbative calculations (some directly relevant for collider experiments) - Non-perturbative applications through Seiberg-Witten theory - Investigation into the application of twistor techniques within the so-called AdS/CFT correspondence For a successful project along these lines, it is essential that the research is embedded in an environment with a broad range of interest and expertise in high energy physics. The Niels Bohr institute represents such an environment.

Keywords: quantum field theory,scattering amplitudes,twistor methods
Learning and rehabilitation using haptic, audio and visual feedback in virtual reality environments (LR HAV VRE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-10-01
End date: 2012-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The ability to navigate spaces independently, safely and efficiently is a combined product of motor, sensory, and cognitive skills.Sighted people use the visual channel to gather information required for this mental mapping.Lacking this information, people who are blind or visually impaired face great difficulties in exploring new spaces. Research on orientation and mobility skills of people who are blind indicates that support for the acquisition of efficient spatial mapping should be supplied at two main levels: At the perceptual level the haptic, auditory, and olfactory channels become powerful information suppliers about unknown spaces; at the conceptual level, the focus is on supporting the development of strategies for efficient mapping and generation of navigation paths. The main goal of this research is to attain a thorough understanding of cognitive mapping process of complex unknown spaces by people who are visually challenged, when the exploration of the spaces is based on haptic, auditory, visually, and conceptual feedback supplied by a virtual learning environment (VLE). The research questions are: What are the VLE components that appear to have significant value?Does simulated walking in the VLE contribute to the construction of an efficient cognitive map?How does this cognitive map contribute to the person’s performance in the real space under short-term and long-term retrieval conditions? Four independent variables will be considered: type of disability; age of vision loss; type of environment – VLE with haptic and auditory feedback, VLE with haptic feedback, VLE with haptic, auditory and visual feedback, VLE with haptic and visual feedback, and real space; and time– performance in the real space immediately after the exploration and about a year later. Three sets of dependent variables were defined: the exploration process of unknown space; the cognitive mapping process and outcomes; and the implementation of the constructed map in the real space.

Keywords: learning studies,rehabilitation,perception,cognitive map,blind,visually impair,information communication technology,computer-assisted education,human-computer interface,virtual reality,haptic
Role of angiogenesis in leukemia (LEUKEMIA AND VEGF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2009-01-01
End date: 2012-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

Our interest is to understand the role of VEGF expression and angiogenesis in leukemogenesis. Recently, emerging data is suggesting that in addition to promoting the growth and metastatic spread of solid tumors, angiogenesis may play an important role also in the pathophysiology of hematological malignancies. Clinical studies indicate that leukemia patients express high levels of pro-angiogenic factors such as VEGF and have increased angiogenesis in the bone marrow. However, these findings are mostly correlative and genetic proof that VEGF expression and angiogenesis support leukemogenesis is still lacking. Furthermore, the molecular mechanisms leading to high VEGF production in leukemia have not been elucidated. The transcription factor HIF-1a is the main positive regulator of VEGF expression. We therefore hypothesize that HIF-1a upregulation may cause high VEGF expression in leukemic blasts and propose to: 1) Elucidate the cause of VEGF expression in leukemic cells; 2) Study the effect of HIF-1a and VEGF overexpression on normal hematopoiesis; 3) Study the effect of HIF-1a and VEGF overexpression on leukemia onset and progression. We plan to achieve these objectives by an inter-disciplinary approach consisting of the analysis of in vitro experiments, in vivo data and clinical data. The expression of HIF-1a will be analyzed in leukemia clinical specimens and cell lines in correlation with VEGF levels, angiogenesis and disease progression. In parallel, in vivo studies in mice will address whether overexpression of HIF-1α or VEGF perturbs normal hematopoiesis and promotes leukemogenesis. These mouse models will be instrumental to test the efficacy of anti-angiogenesis and anti-Hif-1α inhibitors in the future. Funding of this proposal will foster the European reintegration of a talented scientist with extensive training in the United States while also strengthening the cooperation of European institutions with prominent research centers in the United States.

Keywords: health sciences,leukemia,angiogenesis,vegf,bone marrow,transplantation,pml-raralpha,bcr-abl,hif-1,mouse models,preclinical studies
Relationships carotenoid composition-antioxidant activity. Assessment of possible interaction effects. (INTERCAROTEN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2008-09-01
End date: 2012-10-01
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The antioxidant activity (AA) of individual carotenoids has been much studied although data on possible interactions among them in mixtures are scarce. Since complex mixtures are ingested with foods, experiments addressing that question are needed. Thus, the assessment of the in vitro AA of extracts from carotenoid-rich staples will assist, through the application of statistical methods, in the design of model solutions to further study the existence of possible interactions among them. The conclusions obtained are expected to help design in vivo studies and optimized mixtures for food fortification. Changes in the biosynthesis of carotenoids and concomitant changes in AA in oranges over ripening will be also surveyed. The results obtained will be useful for the objectives described above as they accumulate virtually all the carotenoids regarded as most important for human health (the provitamins A α- and β-carotene and β-cryptoxanthin, as well as lutein and zeaxanthin, Cara Cara oranges accumulating lycopene naturally). In addition, they will help understand the control of their synthesis in plants, since although such process are well-known biochemically, their regulation remains poorly understood. This part of the project is therefore intended to supply data for later initiatives, oranges being appropriate food models as they deposit carotenes, mono- and dihydroxycarotenoids, epoxicarotenoids and apocarotenoids, as well as high amounts of Z-isomers, which are raising growing interest. Lastly, the applicability of the objective measurement of colour in the quantitative estimation of carotenoids and their in vitro AA will be assessed. This research line is meant to propose such techniques for rapid measurements of those parameters, since their inherent characteristics (ultrafast non-destructive measurements, versatility, portability, etc.) make them potential tools to be harnessed for quality control.

Keywords: antioxidants,biosynthesis,carotenes,carotenoids,citrus,colour,foods,objective measurement of colour,oranges,multivariate statistics,phytochemicals,pigments,colorimetry,xanthophylls
Development of fast and cost efficient methodology for bovine parental verification and identification with DNA markers. (UNICATTLE ID)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2008-03-03
End date: 2011-03-02
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The presented research proposal is foreseen as close collaboration of know-how university and animal breeding sector under the research leadership of experienced researcher. Pedigree verification and identification by means of DNA testing in feasible, but not applied at the practical level yet. There are still an obstacles such as: lack of general knowledge about this type of analysis, lack of cost effective, simple and fast methodology. At the moment, in the north – western region as well as in other parts of Poland, blood groups testing is the only way to resolve the problem of individual origin. This method, has low reliability, and has a very high cost. It demands very high state subsides every year. Therefore with this ERG grant we propose to develop an innovative, simple, fast and cost efficient methodology of parental testing by mean of DNA testing. Proposed methodology has several advantages over blood testing system, to name some of them: lower sampling cost, sampling non invasive, lower analysis cost, higher power of verification, additional possibilities of identification. Described methodology is based on hair bulbs as a DNA source, multiplex PCR reaction and incorporation of heritable trait X as quality check of performed analysis.

Keywords: laboratory animal science,animal genetics,animal diagnostics,animal breeding