Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unravelling gamma delta T cell emergence and responses in the uterus (UTERUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Gamma delta (gd) T cells constitute a small proportion of blood lymphocytes, but are enriched at barrier sites, where they reside in close contact with epithelial cells. Their location at sites of pathogenic insult and cellular transformation, together with their ability to promptly respond to tissue alterations, places them in a central position in immune protection. We have shown that epithelial molecules direct the development of tissue-specific populations of gd T cells. Indeed, we have identified a role for epithelial-expressed butyrophilin-like (Btnl) proteins in driving the development of epidermal and intraepithelial gd T cells. Importantly, the requirement for Btnls is conserved in intestinal gd T cells in humans. In this project, we will focus on uterine gd T cells, which are arguably one of the least understood populations of gd T cells. These cells bear a specific, invariant T cell receptor, and are thought to become precommitted to an IL-17A-secreting programme during early ontogeny. In other tissues, these cells, termed gd17, can rapidly produce the pro-inflammatory cytokine IL-17A following infection, thereby contributing to limiting infection with bacterial and fungal pathogens. In addition, gd17 cells have been shown to play a role in tissue repair, including promotion of fracture repair. However, the inflammatory effects of IL-17A can also lead to exacerbation of tissue damage and to a pro-tumorigenic effect. In this project, we will determine the functional characteristics of uterine gd T cells, and identify novel factors guiding the development and homing of these cells. Understanding the cues driving gd T cell development and activation at specific body niches is not only essential from a basic research standpoint, but may reveal novel drug targets for various clinical conditions, particularly in the face of emerging infections targeting the female reproductive tract and hindering embryonic development.

Keywords: gamma delta t cells,lymphocyte biology
Following a path of breadcrumbs: How fish recognize landmarks during navigation (FISHNAV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-31
End date: 2020-10-08
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Reliable vision-based object recognition is of fundamental importance to a wide range of species; however, it can be difficult as the appearance of an object can vary greatly as a result of changes in viewpoint. Recognition during motion presents a particularly challenge as the appearance of an object continuously changes; a particular issue for animals that use landmarks to navigate. One recognition mechanism is to learn a two-dimensional snapshot of an object from a set viewpoint. The object can later be recognized once the appearance of the object matches the stored snapshot. Some animals reduce the number of required snapshots by employing ‘active vision’, where they follow identical routes between landmarks. For fish, the complexity of recognition is compounded by the fact that, unlike surface-bound animals, they can freely move vertically, which could potentially increase the number of approach views to an object. An alternate possibility is that fish have a ‘view invariant’ recognition system and can generalize learned representations of objects so that they can be recognized from different viewing angles. However, high-level visual functions, such as object recognition, are associated with complex mammalian brain structures and may be impossible for animals lacking similar neural circuitry. Despite these problems, we know that fish are capable of navigating efficiently using landmarks. The goal of this project is to investigate how fish recognize visual landmarks during navigation and to determine how they cope with self-orientation related changes in the appearance of objects during motion. Using behavioural experiments, we will test whether fish have view invariant recognition and/or if they employ active vision during navigation. The proposed project will further our knowledge of how fish perceive their visual environment as well as inform us about how conserved the mechanisms of object recognition are from an evolutionary perspective.

Keywords: vision,navigation
A Marketable Polymer based Al-S battery (AMAPOLA)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Poland,Denmark,United Kingdom,United Kingdom
Call: EIC Transition to Innovation Activities (H2020-EIC-FETPROACT-2019, 2019)
Start date: 2020-10-01
End date: 2023-03-31
Duration (months): 30.0
Total project cost (EUR): 2000345.0
EU funding (EUR): 2000345.0
Participants: 8
Project status: CLOSED

AMAPOLA will foster the developments achieved in the FET-Open SALBAGE project, towards real applications and towards market. The focus will be put in turning the promising research results obtained in SALBAGE into genuine technological innovations demonstrating that Al-S based batteries can have a place in certain market niches as a new future technology on batteries. The project is founded in the combination of sulfur and aluminium in a battery, what is especially attractive because of the very high abundance of both elements. The Al-S cell has the potential to store very high energy, and very high prospective values of energy density of 660 Wh/l and specific energy of 400 Wh/kg are calculated at a cell level, taking advantage of the incorporation of novel solid Polymer Gel Electrolytes (PGEs) based on novel highly conductive and inexpensive Deep Eutectic Solvents (DES) for a cheaper, lighter, tougher and safer battery concept. In AMAPOLA project the focus will be put in: 1- further develop the materials proposed in SALBAGE with special emphasis in (i) the preparation of controlled-phase gel electrolytes from highly conductive novel DES; (ii) the development of advanced cathode formulations to achieve high sulfur loading and high sulfur utilisation in the cathode in combination with new promising redox mediators and (iii) strategies to overcome the presence of oxide layer in the aluminium anode. 2- in up-scaling and extrapolation towards real application 3- pre-industrialization and market aspects. To succeed in the high demanding tasks, most part of the former consortium that have shown outstanding competence and remarkable level of commitment in SALBAGE is present in AMAPOLA together with a world recognised battery company and an SME expert in IPR managent and transfer to market.

Keywords: al s,aluminium,sulfur,sulpuhr,electrodes,polymer gel electrolyte,battery,deep eutectic solvent
Balkan Peoples of Anatolia: Migration, Assimilation and Cultural Contact in Anatolia around 1400 BC-300 BC. (Balkan Peoples)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

The project aims to explore the history of Balkan peoples of Anatolia in the 2nd and 1st millennium BC from a cultural and an ethnolinguistic perspectives. The term ‘Balkan peoples’ refers to different ethnic groups which migrated to Anatolia from the Balkan region before ca. 500 BC, spreading eventually in its western, northern and central parts and pushing back the older Indo-European population of the region (the Hittites and different Luwic ethnolinguistic groups). Linguistically, the Balkan peoples are speakers of Indo-European languages belonging to a group conventionally dubbed ‘Balkan Indo-European’, which includes also Greek, Armenian and Albanian. The project will focus on four principal topics: 1) chronology and extent of the Phrygian migration and settlement in Anatolia; 2) Balkan component in the language and culture of the Lydians; 3) the question of an early (before ca. 1200 BC) presence of the Balkan ethnic element in Anatolia; 4) Thracian migration to Anatolia and the question of ethnolinguistic identity of northern Anatolia in the 1st millennium BC. The project has an emphatically interdisciplinary character combining apparatus and methods of Classics, Ancient Near Eastern studies, comparative and areal linguistics, epigraphy and, to an extent, archaeology. It aims to recreate an integral picture of ‘ethnocultural Balkanization’ of Anatolia, a phenomenon whose extent and significance is largely underestimated in the modern literature. Besides direct evidence concerning the migration and spread of Balkan peoples in Anatolia, such as reports of Greek authors or epigraphic material in epichoric languages, much weight will be put on the analysis of indirect evidence presented by personal onomastics and toponymy, a rich but hardly exploited material bearing on the question of distribution of different ethnic groups in the region.

Keywords: ancient anatolia,balkan migration,phrygian,lydian,cultural contact,language contact,onomastics
Bioeconomy Awareness and Discourse Project (BioCannDo)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Coordination and support actions
Partnership: BBI (Art-187)
Countries involved: Italy,Germany,Belgium,Belgium,Netherlands,Netherlands
Call: Communication and awareness (H2020-BBI-PPP-2015-2-1, 2015)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 998570.0
EU funding (EUR): 998345.0
Participants: 6
Project status: CLOSED

The Bioeconomy Awareness and Discourse Project (BioCannDo) will raise awareness and acceptance of the broad public towards the bioeconomy and bio-based products through a strategic, stakeholder-driven information campaign and education. Convincing people that the bio-based economy offers something desirable, with new products, functionalities and applications for their daily life, that provide answers to societal concerns (e.g. climate change), requires neutral and science-based information. BioCannDo will present such information in a way that is easy to understand for the broader public. It will provide various means for feedback, interaction and encourges engagement in a discourse on common questions and concerns. Collaborating with bio-based stakeholder networks and communities at EU, regional and national level, BioCannDo will provide information, educational materials and key communication messages through such channels as a community of related projects and educational partners and an Inhub which combines different means of online communication (i.e. social media, blogs, videos, journalistic articles). BioCannDo will build on the legacy of previous projects (i.e. by using their networks, or social media accounts), existing material developed by them and be active in collecting, connecting, aggregating and reformulating content from different actors and resources. It will generate new content addressing the most urgent gaps in information and education. Such dual approach will help to maximise synergies and increase impact of both existing and new material. The developed content and key communication messages will be assessed and tested by stakeholders and target users through focus groups and a market survey. Findings will be used in feedback loops to adapt the content and messages.
Non-Conventional Wave Propagation for Future Sensing and Actuating Technologies (NOCTURNO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Australia,Italy,Switzerland,Bulgaria,Serbia,United States,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-01-01
End date: 2023-06-30
Duration (months): 66.0
Total project cost (EUR): 580500.0
EU funding (EUR): 553500.0
Participants: 10
Project status: SIGNED

New sensing devices and technologies are the key in addressing numerous challenges that agriculture is facing today. Namely, to provide more food for the ever-growing population, a number of biophysical parameters of plants, soil and food products need to be monitored and measured constantly, thus providing valuable data needed to optimize the entire agricultural process. In addition, the corresponding actuating technologies responsible for applying various measures (e.g. irrigation, fertilization) need to become more precise and allow variable rate inputs with a resolution down to an individual plant. To provide novel sensing and actuating solutions able to address the burning issues in agriculture today, NOCTURNO will bring together and synergistically advance several highly promising research directions which have been investigated separately in the last decade: wave-matter interactions, plasmonics, complex media and artificial materials, acoustic, electromagnetics, optics, bionanosensing. The Project will focus on development of sensors and actuators based on non-conventional propagation of acoustic waves in artificial media, electromagnetic/optical sensors based on metasurfaces, and advanced manufacturing technologies including 3D printing, laser-micromachining technology, and e-beam lithography with the aim to provide practical solutions for the fabrication of novel acoustic and metasurface-based sensors and actuators. NOCTURNO proposes an exchange programme which brings together three European academic institutions, two European SME companies, and two third-country universities. The consortium has the specific expertise in the fields listed above and it will create synergies that will first advance the current level of fundamental scientific knowledge and then support its transformation into innovative products with the high potential to revolutionize the agri-food sector.

Keywords: sensors,actuators,acoustics,optics,plasmonics,wave propagation
PROtotype Demonstration Using low-cost Catalysts for Electrolysis to H2 (PRODUCE-H2)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-05-01
End date: 2020-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

Hydrogen (H2) generated from renewable energies, such as solar and wind, and water has a huge potential as a carbon-free energy vector which can be exploited on demand through fuel cell technologies. Proton-exchange membrane electrolysers (PEMEL) are a mature technology that can be coupled with intermittent renewable power sources. However their wide deployment still depends on innovative breakthroughs regarding the design of alternative catalysts avoiding the use of precious metals and fulfilling three main characteristics: sustainability, cost-effectiveness and stability. In the “PhotocatH2ode” ERC Frontier Research Starting Grant (consolidator stream), we explored a coordination polymer structure for amorphous molybdenum sulfide (a-MoSx), refined the understanding of its catalytic mechanism (Artero and coll., Nature material 2016) and developed strategies to remedy reductive corrosion issues that so far limited the implementation of such earth-abundant H2 evolution catalysts in PEMEL. We aim at exploiting these new findings in PRODUCE-H2, an ERC Proof of Concept project which proposes to (1) optimize the formulation of these catalytic materials and assemble them in polymer-membranes, (2) assessing their performance and quantifying their stability during long-term tests performed under realistic operating conditions, (3) upscaling their production thanks to a newly developed synthetic process and (4) implementing them in a noble-metal-free PEMEL prototype. PRODUCE-H2 will exploit pre-existing and newly created intellectual property with the aim of proposing a cost-effective industrial solution for PV-coupled on-site hydrogen production. This project will be in close collaboration with Toyota Motor Europe who have been selling fuel cell cars since 2015.

Keywords: electrocatalysis,photo electrocatalysis,hydrogen,artificial photosynthesis
Find Research Everywhere, SHare and expERience (FRESHER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Bulgaria,Bulgaria,Bulgaria,Bulgaria,Bulgaria,Bulgaria,United Kingdom
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-05-01
End date: 2021-04-30
Duration (months): 12.0
Total project cost (EUR): 132376.25
EU funding (EUR): 130056.0
Participants: 20
Project status: CLOSED

Twenty partners in Bulgaria come together for European Researchers Night ‘20 to present FRESHER (Find Research Everywhere, SHare and expERience) - a 12-month project led by the Centre for Research & Analysis, in a Consortium, now in its 5th year, with the Bulgarian Academy of Sciences, universities, research institutes, the only Bulgarian tech park, a chamber of industry and commerce, the local office of a pan-European organisation, education entrepreneurship, and associate partners. FRESHER offers a series of specially curated, coordinated, multi-day participatory events at over 50 venues and 30+ schools in 25 cities/towns/villages. The talks, shows, hands-on experiments, lab visits, citizen research, competitions will reach 3.6 mln, and engage directly with 30,000 in face-to-face events at schools, libraries, museums, academic and outdoor venues, public transport and online. Building on well researched, popular formats for researchers’ engagement with the public, FRESHER provides multidisciplinary content around the International Year of Plant Health. The topic will feature in the programmes of all partners to assert the relevance of research to everyday life. Building on the Consortium’s existing understanding developed through previous local initiatives including Researchers Night, and addressing findings of research (MASIS report, Education & Training Monitor 2019 for Bulgaria, Women in Digital Scoreboard 2019, Science, Research & Innovation Performance in EU 2018), FRESHER focuses on enhancing public engagement with research and shortening the gap in the decision of young people and girls in particular to choose STEAM careers. The activities will step on previous evaluation and generate fresh, aligned data. The project will strengthen the capacity of all partners to organise accessible events for the general public, and to tailor messages for underserved audiences, including girls, young people at risk of school drop-out, as well as people with special needs.

Keywords: researchers,night,bulgaria,msca,innovation,research,science communication,inclusion,hands on
Structural dynamics of acyl carrier protein complexes through combined solution and solid-state NMR (ACPNMR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-10
End date: 2017-09-09
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Antibiotics are a vital part of modern medicine. However, the available arsenal of antibiotics becomes less effective as microorganisms develop "resistance" against them. The resulting crisis in medicine necessitates development of new drugs. Natural products inspired compounds are a potential solution to this challenge. For example, gladiolin biosythesized by a mulitenzyme polyketide synthase (PKS) was shown to be active against Mycobacterium tuberculosis, a multidrug resistant bacterium that one third of world’s population is infected with. The PKS producing gladiolinum is a good example of multienzymatic assembly lines that due to their modular nature are ideal for genetic manipulation paving the way for synthetic biology approach to produce new drugs (that are difficult to synthesize using chemical methods). However, for such approach to be successful it is crucial to understand molecular level structural and dynamical factors responsible for controlling directionality and specificity of biosynthesis. Neglecting such factors, when modifying PKSs often results in assembly lines that are inactive or dysfunctional. Here we propose to use a novel approach combining state-of-the-art solution and solid-state NMR methods to investigate structure, dynamics and interactions of proteins from module 12 of gladiolin PKS, particularly acyl carrier proteins (ACP12a and ACP12b) and special adapter ketosynthase (KS12), all of them highly required in industrial biosynthesis toolbox. We will use solution NMR to characterize isolated ACPs and solid-state NMR to study ACPs-KS12 complexes (direct structural information is difficult to obtain by solution NMR due to the large complex size). Combining solution and solid-state NMR relaxation methods will allow us to probe protein motions over 6 orders of magnitude providing a comprehensive picture of relevant dynamic changes in ACPs-KS12 complexes.

Keywords: solution and solid state nmr,gladiolin,polyketide synthase,synthetic biology,molecular modelling,antibiotics