Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
New Energy Material (NEM)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: United Kingdom
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-01-01
End date: 2014-06-30
Duration (months): 18.0
Total project cost (EUR): 160175.4
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

There are a range of emerging solar technologies which are pushing to achieve power conversion efficiencies of similar values to thin film solar cells, but with a materials base and manufacturability of a much lower cost. Within the ERC starting grant HYPER, we have developed a new solid-state absorber material and device structure, which represents a distinctly new emerging solar technology based on solution processed inorganic and organic semiconductors. This new material system has delivered power conversion efficiencies, as measured under simulated AM1.5 sun light at 100 mWcm2 irradiance, of over 10% which puts it at the very top of the emerging PV technologies. Beyond performance however, in order to “prove” commercial viability, long term stability needs to be demonstrated. Within this proof of concept project, long term stability will be externally verified, and a strong IP position and strategy will be developed through professional IP strategists.

Keywords: 279881
7kDa TSLP as a novel type of anti-inflammatory agent to re-establish immune homeostasis (7TREIMHO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Italy
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-07-01
End date: 2014-06-30
Duration (months): 12.0
Total project cost (EUR): 163916.8
EU funding (EUR): 146917.0
Participants: 2
Project status: CLOSED

Intestinal homeostasis is a complex event that relies on different interactions between the host and the commensal flora, also called microbiota. The microbiota is a source of gene products that are required for several functions linked to digestion and energy harvest, thus it has to be tolerated, but at the same time controlled. We have shown that the capacity to tolerate the microbiota is linked to a close interaction between epithelial cells, that are the first line of defence against luminal microorganisms, and specialized immune cells called dendritic cells, that acquire a tolerogenic phenotype and drive the development of T regulatory cells, capable to control the development of inflammatory responses to bacteria. We have identified several effectors mediating this control and focused on a cytokine called thymic stromal lymphopoietin (TSLP) that is released constitutively by epithelial cells and is strongly downregulated in inflammatory bowel disease (IBD). By contrast, in other inflammatory disorders like allergy or asthma, TSLP has been shown to be upregulated and to mediate disease. This apparent controversy is solved when considering that TSLP comes in two different isoforms: a short (sTSLP) and a long (lTSLP). sTSLP has been completely neglected in the literature as most of the reagents do not distinguish it from lTSLP. Within the ERC project Dendroworld, we have generated all the tools to study the function of these two isoforms. We discovered that in IBD there is an inverse correlation between sTSLP and lTSLP. lTSLP is drastically upregulated by recruited immune cells, while sTSLP is downregulated in epithelial cells. Hence, we hypothesized and confirmed that the two isoforms had different activities, with the sTSLP being anti-inflammatory and lTSLP being inflammatory. In this POC we propose scientific and commercialization activities to bring sTSLP to the market as a new class of anti-inflammatory drugs capable of re-establishing immune homeostasis.

Keywords: 202896
Market potentials of ALK vaccination as a new strategy for the cure of ALK positive tumors such as lymphoma, lung carcinoma and neuroblastoma (ALKVAX)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Italy,Italy
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-06-01
End date: 2014-05-31
Duration (months): 12.0
Total project cost (EUR): 166933.6
EU funding (EUR): 149938.96
Participants: 2
Project status: CLOSED

ALK positive cancer such as Anaplastic Large Cell Lymphoma (ALCL), Non small Cell Lung Carcinoma (NSCLC) and neuroblastoma are important cancers of children and adults, currently treated with standard chemotherapy and radiotherapy, with unpredicatable and poor results, in particular in the case of NSCLC and neuroblastoma. In August 2011, the US Food and Drug Administration (FDA) had an accelerated approval of a novel drug (called Crizotinib) to treat NSCLC that express abnormal ALK protein. Phase II and III clinical trials are ongoing to test the same drug in ALCL and neuroblastoma. However, it is now clear that the treatment with Crizotinib has a good initial efficacy and response, but the cancer inevitably relapses because of the occurrence of drug resistance. This resistance is due to selection of ALK point mutants that no longer bind the inhibitor. New drugs to tame the resistant cells will be probably developed in the future (as happened for Gleevec and second and third generation of BCR-ABL inhibitors), but it is expected that again resistance will emerge. As part of a research conducted under an ERC Starting Grat, we developed a new therapy for ALK positive ALCL, NSCLC and neuroblastoma based on the generation of a potent and specific anti-tumor response based on the development of an ALK-targeted immune response. This specific anti-ALK immune response is achieved by an anti-ALK vaccination in preclinical mouse models of ALCL and NSCLC. Now, in this Proof-of-Concept grant, we propose to take the next steps to move our invention toward a clinical application in human patients, by testing GLP formulations of the vaccine, its potential toxic effects and by searching the market for companies interested in its development and commercialization. Our goal is to understand and finalize the best strategy to move this experimental therapy to the market and generate a partnership with a pharma company.

Keywords: 242965
Smart Vaccine Depots (SMARTVACCINES)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Germany
Call:  (ERC-2012-PoC, 2012)
Start date: 2012-11-01
End date: 2013-10-31
Duration (months): 12.0
Total project cost (EUR): 164162.0
EU funding (EUR): 149194.0
Participants: 1
Project status: CLOSED

Vaccinations are a highly efficient and effective means for protecting humans and animals against severe diseases. For reaching an initial protective immune response, the vaccine must repeatedly be administered, mainly by injection. Omitting the repeated vaccine injections either due to the unavailability of medical personnel (mainly in developing countries) or due to negligence results in insufficient protection and susceptibility to disease. One solution for overcoming this lack in protection would be a vaccination strategy avoiding the need for additional appointments with medical personnel. This could be realized by the use of a vaccine depot that is injected together with the first vaccine dose. At a preset time point the patient would simply swallow a pill containing a trigger substance that would subsequently induce the release of the vaccine from the depot and induce the subsequent protection of the patient. In this project we will perform the proof of concept for the functionality of such a depot in animal models using vaccines against widespread infectious diseases like hepatitis B or human papilloma virus. With this study we aim at demonstrating the proof of concept that our newly developed materials can be applied to increase the patient compliance of vaccinations and thereby to increase the vaccination success rate. As our approach is likely generically applicable to different vaccines, we anticipate a highly attractive economical potential in the human medical and the veterinary fields. The scientific data obtained in this project together with a comprehensive market research and the development of a business strategy will shape a highly attractive commercial proposition for the successful valorization of our current ERC-funded research.

Keywords: 259043
HYdrogen cells for AiRborne Usage (HYCARUS)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Germany,France,European organisations area,Spain,France,France,Czechia
Call:  (FCH-JU-2012-1, 2012)
Start date: 2013-05-01
End date: 2019-03-31
Duration (months): 71.0
Total project cost (EUR): 12064473.93
EU funding (EUR): 5219265.0
Participants: 10
Project status: CLOSED

In order to meet the increasing pressure to reduce fuel consumption and greenhouse gas emissions, airlines are seeking alternative sources to power non-propulsive aircraft systems. The next generation of aircraft is heavily investigating the use of non-fossil fuel to generate electrical power for non-essential applications (NEA). Hydrogen fuel cells are actively being pursued as the most promising means of providing this power. Fuel cells also have the added benefits of no pollution, better efficiency than conventional systems, silent operating mode and low maintenance. The by-products from the fuel cells (heat, water and oxygen depleted air) will also have a positive impact on the global aircraft efficiency when they are harnessed and reused within the aircraft system. The HYCARUS project will design a generic PEM fuel cell system compatible of two NEA, then develop, test and demonstrate it against TRL6. A secondary electrical power generation model for a business executive jet will be run. The application will be tested with the fuel cell system and the storage system under flying conditions. Furthermore, investigations will be made to understand how to capture and reuse the by-products. The HYCARUS project will extend the work already completed in the automotive sector, particularly for safety codes and standards, and develop these for use in airborne installation and applications. Improvements in terms of efficiency, reliability, performance, weight /volume ratio, safety, cost and lifetime under flight conditions at altitude and under low ambient temperatures (mainly in the air) will also be examined. The HYCARUS project also aims to foster a better and stronger cooperation between all the agents of the sector: Aeronautics equipment and systems manufacturers, aircraft manufacturers, system integrators and fuel cell technology suppliers.

Keywords: fuel cell systems,aircraft,galley,non essential applications,gas supply system,hydrogen gas support equipment,membrane electrode assembly,oxygen depleted air,proton exchange membrane,system safety
Understanding the Degradation Mechanisms of a High Temperature PEMFC Stack and Optimization of the Individual Components (DEMSTACK)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Collaborative project
Partnership: FCH (Art-185)
Countries involved: Greece,Spain,Czechia,Greece,European organisations area,Norway
Call:  (FCH-JU-2012-1, 2012)
Start date: 2013-05-01
End date: 2016-10-31
Duration (months): 42.0
Total project cost (EUR): 2576615.0
EU funding (EUR): 1495680.0
Participants: 7
Project status: CLOSED

The activities of the DeMStack project will be on the stack optimization and construction based on the high temperature MEA technology of ADVENT S.A. and its long term stability testing in combination with a fuel processor. DeMStack aims to enhance the lifetime and reduce the cost of the overall HT PEMFC technology by integrating promising, already developed materials for electrodes and membranes in an existing stack design. By understanding the fundamentals of the failure mechanisms, we can improve components, and design and develop system approaches to mitigate the failures. The strategy aims at improvements based on degradation studies and materials development carried out in previous and ongoing projects (FCH JU DEMMEA 245156) so that they will lead to a reliable cost-effective product that fulfils all prerequisites for relevant field uses. These improvements cope with degradation issues related to catalyst utilization, reformate feed contaminants, uniform diffusivity and distribution of reacting gases in the catalytic layer, pinhole development due to local high current density spots, H3PO4 acid depletion and distribution within the MEA, startup-stop and thermal cycles. The ultimate aim of DeMStack is to deliver HT PEMFC components for operation temperatures at 180oC and up to 200oC. Mainly optimized long lasting polymer electrolytes, stable Pt based electrocatalysts with minimal Pt loads and effective architectures of flow fields on bipolar plates will be explored. DeMStack will design, manufacture and test under variable conditions a highly efficient, low-cost HT PEMFC 1 kW stack prototype constructed from the optimized components. A fuel processor will also be constructed, operating on natural gas or LPG, which will be combined and integrated with the fuel cell stack. The robustness of the stack, the simplicity of BoP, the operational stability and the user friendly operation of the integrated system into a commercially reliable product, will be demonstrated

Keywords: ht pemfc,scaling up,polymer electrolyte,pt based electrocatalysts,degradation mechanisms,stack manufacturing,bipolar plates,mathematical modelling,engineering impimization,fuel processor
Laser welding of newly developed Al-Li alloy (LAWENDEL)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Germany,United Kingdom
Call:  (SP1-JTI-CS-2012-02, 2012)
Start date: 2013-01-01
End date: 2015-05-31
Duration (months): 29.0
Total project cost (EUR): 149996.2
EU funding (EUR): 112497.15
Participants: 2
Project status: CLOSED

The proposed LAWENDEL project aims to develop laser welding process for aerospace applications by combining expertise in model based process design at the University of Manchester with a systematic experimental approach by the project coordinator, Helmholtz-Zentrum Geesthacht. The objective is to study the laser weldability of a newly developed Al-Li alloy, to determine the process parameters needed to obtain consistent laser welds, and to compare the mechanical behaviour with the conventional aluminium alloys series. The study will emphasize the microstructure characteristics and the mechanical properties of the weld joint to gain an understanding of the underlying factors controlling the performance of the welds. During the demonstration phase of the project, the developed LBW technology will be applied for welding a stiffened flat panel out of the new Al-Li alloy, named demonstrator B1, in order to evaluate the industrial application. The skin and the stiffener will be provided by Topic Manager. The demonstrator B1 is a rectangular aluminium panel 384 mm x 742 mm (AA2198) with 4 stringers out of AA2196 spaced in equal distances. Three demonstrator panels will be welded by using the optimized parameters defined from the previous phase and then inspected by NDT in order to assure the structural integrity. The innovative combination of state of the art modelling and experiments will enable physics based optimization of the welding process with greatly reduced time and cost compared to traditional trial and error methods.

Keywords: laser beam welding,al-mg-li alloy,parameter optimization,modelling of microstructure evaluation,aluminium lightweight structure
Transition-metal / lanthanide dyads for two-photon cellular imaging (TRAMLANES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-08-05
End date: 2015-08-04
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

The proposed project is to use the combination of d-block and f-block units in the same dinuclear complex for parallel two-component luminescent imaging of different species in cells. This will rely on the unprecedented combination of two-photon excitation of a d-block luminophore (Pt- or Ir-based) having a long-lived excited state, followed by partial d-f energy-transfer to sensitise the lanthanide ion. This will generate two-component luminescence (blue, from the Ir/Pt unit; green or red, from the Tb or Eu unit, respectively) in which the two luminescence components have lifetimes that differ by three orders of magnitude (microsecond for d-block luminescence; millisecond for lanthanide luminescence). These different emission components can be selected at the detection stage using time gating such that purely one or the other, or a desired combination of both, can be detected in a given time window. In addition to providing two luminescence outputs with different colours and lifetimes, each luminescence component is independently sensitive to different species in cells and can therefore be used for imaging. The lifetime of Pt or Ir-based emission, from an 3MLCT excited state, is sensitive to quenchers such as dioxygen and variations in the luminescence lifetime in different parts of a cell can be used to visualise this. In contrast the relative intensity of Eu-based emission bands varies with the concentration of chelating anions such as citrate and hydrogen carbonate, allowing ratiometric intensity-based sensing of these species. Thus these d/f complexes will for the first time allow two different species to be imaged in real time using a single molecule under two-photon excitation conditions, which would constitute a major advance in the field with clear potential applications.

Keywords: c118 photochemistry,c132 coordination chemistry,c142 molecular chemistry,c104 molecular architecture and structure,c103 spectroscopic and spectrometric techniques
Novel aircraft de-icing concept based on smart coatings with electro-thermal system (ICECOAT)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: United Kingdom,United Kingdom
Call:  (SP1-JTI-CS-2012-02, 2012)
Start date: 2013-05-01
End date: 2016-04-30
Duration (months): 36.0
Total project cost (EUR): 399999.6
EU funding (EUR): 228292.5
Participants: 2
Project status: CLOSED

Objective of ICECOAT project is to minimise the run-back icing over the natural laminar flow (NLF) wing surface by optimising the anti-icing coatings and electro-thermal de-icing system. This will help implement the laminar flow control technology currently investigated by Clean Sky Joint Undertaking. This objective will be tackled by a combination of four technical work packages, including Wettability and ice adhesion study (WP1), Development of smart anti-icing coatings (WP2), De-icing by electro-thermal system (WP3) and Validation of mixed strategies (WP4), together with Administrative work (WP0) and Dissemination/exploitation (WP5). The proposed work will be carried out by advancing our understanding of the heat transfer processes that determine runback icing accretion by fully considering the influence of both trapped air pockets and water within the developing ice matrix. We will also select and/or develop new types of coating matrices, new nanoparticles for nanocomposites, and new method for coating surface modification to produce anti-icing coating with higher hardness and erosion resistance. These new anti-icing coatings are tested in conjunction with an electro-thermal de-icing system, which will be optimised for its location over the wing. Pulsing operation of deicing system will also be tested to minimise the occurrence of run-back icing. Finally, the effect of laminar-to-turbulent transition of the boundary layer over the wing surface on the behaviour of run-back icing will be investigated in an icing wind tunnel.

Keywords: aircraft,anti-icing,smart coatings,icephobic coatings,de-icing,electro-thermal system,run-back icing,natural laminar flow,laminar flow control
Smart erosion shield for electro-mechanical de-icers (SMARTERSHIELD)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Spain
Call:  (SP1-JTI-CS-2012-02, 2012)
Start date: 2013-04-01
End date: 2015-07-31
Duration (months): 28.0
Total project cost (EUR): 248800.0
EU funding (EUR): 160000.0
Participants: 2
Project status: CLOSED

The SMARTERSHIELD project will contribute to eliminate the hazards associated with the existence of ice on a lifting or stabilizing surface. The ice accretion increases the aircraft weight, which combined with the reduction of lift, can imply an important increase of the necessary energy to lift the aircraft. SMARTERSHIELD will consider all the possible innovative technologies and concepts that could be useful to accomplish a high efficient new smart erosion shield. Once the ice accretion is produced, the ice morphology can be determined by analysing its crystalline structure by means of a microscope and by determining its thickness (e.g. by calculating the increasing of weight). The de-icing capacity of the SMARTERSHIELD system will be experimentally evaluated by using testing machines or by actuating the system if it is self actuated, all this in a thermal and hygroscopic controlled environment to properly reproduce realistic icing conditions during the test. To maximize the deformation of the leading edge metallic skin (also named "erosion shield"), SMARTERSHIELD will minimize the efforts generated by the mechanical actuators, and provide at the same time capabilities to control the geometry of the deformations, it is proposed to investigate from actuator technologies and materials through structural and material design, using engineering tools such as e.g. Finite Element Analysis.

Keywords: smartershield,de-icing,smart erosion shield,surface,ice,aircraft,thermal,hygroscopic,environment,test,deformation,edge,composites,finite element