Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
NCP EIT Training, Networking and Best Practices Initiative (EIT-BEST)

Framework: Horizon Europe — Innovative Europe
Programme: The European Institute of Innovation and Technology (EIT)
Theme: other EIT
Destination: other EIT
Action type: Coordination and support actions
Countries involved: Greece,Türkiye,Italy,Germany,Czechia,Poland,Albania,Armenia,Belgium,Estonia,Georgia,Iceland,Malta,Moldova, Republic of,North Macedonia,Portugal,Romania,Tunisia,Latvia,Nigeria,Switzerland,Ukraine
Call: EIT National Contact Points (HORIZON-EIT-2024-NCP-IBA, 2024)
Start date: 2025-10-01
End date: 2030-03-31
Duration (months): 54.0
Total project cost (EUR): 3248422.5
EU funding (EUR): 3248422.5
Participants: 24
Project status: SIGNED

The overall aim of EIT-BEST is to address the challenges faced by the network of EIT National Contact Points (NCPs), enhancing their capacity to provide efficient, harmonized, and accessible support services. The project aims to make the EIT and its Knowledge and Innovation Communities (KICs) more visible, accessible, and comprehensible at national, European and global levels. By leveraging the expertise of a diverse consortium of 24 partners with varying levels of relevant experience, spanning 22 countries, EIT-BEST will empower NCPs to deliver standardized and high-quality support services. The project will focus on fostering collaboration with KICs, exchanging best practices, and creating synergies with other EU programs, ensuring the effective dissemination of EIT opportunities and resources. EIT-BEST will implement tailored actions, including targeted training sessions, toolkits for newcomers, and workshops, complemented by events aimed at capacity building and enhancing outreach. These measures will ensure the widespread accessibility and impact of EIT services, strengthening the network of NCPs and amplifying the visibility of the EIT Community.

Keywords: innovation,knowledge triangle,eit,kics,ncps
Biomarkers affecting the transition from cardiovascular disease to lung cancer: towards stratified interception. (PREVALUNG EU)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: France,United Kingdom,Belgium,Italy,Netherlands,Norway,Sweden,Bulgaria
Call: Personalised blueprint of chronic inflammation in health-to-disease transition (HORIZON-HLTH-2022-STAYHLTH-02, 2022)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 7166124.25
EU funding (EUR): 7016124.0
Participants: 13
Project status: SIGNED

Cardiovascular disease (CVD) and lung cancer (LC) are leading causes of deaths and intertwined chronic inflammatory processes associated with metabolism reprogramming, clonal hematopoiesis of indeterminate potential (CHIP), intestinal dysbiosis, and maladaptive immunity. CVD prone-tobacco users exhibit a 1-2% yearly incidence of LC. Low dose computed tomography screening programs reduce LC mortality by 20%. Beyond epidemiological scores, risk identification, early cancer detection and interception are mostly based on cell autonomous approaches. Understanding pathophysiological failures linking CVD to LC would allow to take steps for prevention. Based on metabolo-metageno-proteo-immuno-gen-omics, our PREVALUNG prospective study conducted in CVD tobacco consumers allowed to unveil four drivers of early carcinogenesis leading to actionable biomarkers that can be harnessed to pioneer personalized interceptive measures. Four main objectives will be harnessed by 7 academic partners (transdisciplinarity and trialists in interception), 3 diagnostic Biotech Cies and one nutrition Foundation. First, refine and validate in retro- and pro-spective cohorts (>60.000), the 4 classifiers relying on the 4 inflammatory drivers (autophagy/innate immunity/intestinal barrier defects and CHIP) to implement patient stratification. Second, develop and validate robust friendly-user tools monitoring such biomarkers for routine risk assessment. Third, demonstrate the actionability of these biomarkers through a biologically-informed multi-arm randomised trial testing measures targeting each of the 4 main drivers of inflammation using food supplements or pharmacological agents (metformin, anti-NKG2A/PDL-1 Abs, IL-1 inhibitor, probiotics respectively) in addition to diet and life-style changes to return to homeostasis. Fourth, to adapt a secured interface between patients and clinical researchers using these new tools to the longitudinal monitoring of the interceptive measures.
Demonstrating a cost competitive, sustainable, scalable intensified micro-algae bioprocess for the production of food-grade medium value, carbon negative Ingredients exceeding Market Standards (CleanAlgae2Value)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Greece,Denmark,Belgium,Sweden,Spain,Germany,United Kingdom,Malta,Slovenia
Call: Sustainable micro-algae as feedstock for innovative, added-value applications (HORIZON-JU-CBE-2024, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 10380476.25
EU funding (EUR): 7483217.75
Participants: 15
Project status: SIGNED

Micro-Algae offer a solution to many of the European bioeconomy needs. Nevertheless, significant challenges still exist to their acceptance on the market, including organoleptic and functionality challenges. CleanAlgae2Value seeks to unlock such potential via a cascading approach to white-microalgae-derived medium-price ingredients, including protein isolates, oils, natural pigments and starch. The project will build and operate a replicable “upgrading-module” to drastically enhance relevant biorefineries performance via a cost-competitive, sustainable, and scalable microalgae fractionation and valorisation process for producing food-grade, medium-value, carbon-negative ingredients that exceed market standards. More specifically, the project will prove the effectiveness and efficiency of a “Micro-Algae Biorefinery Upgrade Module” (MABUM), able to unlock productions of protein isolates, protein concentrates, starch-rich fraction and oils (respectively 2, 1.3, 3.98 and 1.8 tons) to be validated into 15 prototypes, 13 for food and 2 for bio-packaging markets. The project will do so while increasing operative margins, by decreasing “value-normalised” CAPEX and OPEX, also thanks to modelling optimisation, contributing to market penetration. Importantly, CleanAlgae2Value would also benefit from synergies with a recently granted EIC Accelerator project, which focuses on upstream algae production from CO2 via SOL two-step fermentation, using solely CO2 as carbon source. The project brings together 16 organizations from 9 European countries, collaborating with end-users to produce added value ingredients. Holistic evaluations, including both empirical (surveys, workshops) and horizontal considerations (LCA, TEA, SSbD), will allow for the assessment of market acceptance and environmental, economic and societal sustainability, as well as further support and boost the project DCE activities and pathways towards EFSA positive opinion for those ingredients that still require it.

Keywords: algae,biorefinery,medium value bioproducts,ingredients and intermediates,iluc free,dsp
Stabilis – Providing relief for tremor patients (STABILIS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-06-01
End date: 2025-11-30
Duration (months): 30.0
Total project cost (EUR): 2337076.25
EU funding (EUR): 1635953.0
Participants: 1
Project status: SIGNED

Millions of people worldwide have trouble with involuntary shaking hands. These shakes are called tremors, commonly seen in Parkinson’s Disease, Multiple Sclerosis, and Essential Tremor. Tremors lead to a lot of frustration. Not only does it make eating and drinking difficult, or impossible, but people are often ashamed. Current treatments to suppress tremors are often inefficient and lead to heavy side effects. There is a need for a new solution. STIL is developing a medical device that will enable people with tremors to return to their activities of daily living. The STIL anti-tremor orthosis (called Stabilis) uses technology that suppresses the tremor but still allows voluntary movement. With its lightweight and ergonomic design, patients can conveniently wear the device when they need it, without the side effects that medication would give. It is STIL’s mission to provide freedom to people who suffer from tremors, allowing them to comfortably live life.

Keywords: artificial intelligence,elbow tremor,shoulder tremor,arm tremor,wellbeing,health,tremor suppression,neurological disorders,orthosis,parkinson s disease,medical devices,ageing society,patient care,essential tremor
Topological Insulator Vertical Cavity Laser Array (Topo Insulator VCSEL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-04-01
End date: 2024-09-30
Duration (months): 30.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Vertical Cavity Surface Emitting Lasers (VCSELs) are tiny semiconductor lasers, structured as pillars of few-microns diameter on a chip, emitting light from their surface. They are now the most commonly used lasers, e.g., in cell phones, car sensors, data transmission in fiber optic networks. Though widely used, the miniscule size of VCSELs sets a stringent limit on the output power it can generate. For years, scientists have sought to enhance the power emitted by such devices through combining many tiny VCSELs and attempting to force them to act as a single coherent laser, with limited success. In a recent breakthrough, which appeared in Science magazine, we presented a new scheme to force very many VCSELs to lock together and act as a single coherent laser source. Our breakthrough, a direct outcome of our ERC AdG, employs a unique geometrical arrangement of VCSELs on the chip that forces the light to move in a specific path – a photonic topological insulator platform. We propose to capitalize on the success and construct proof of concept technology that will bring this topological insulator VCSEL array a major step towards commercialization. We will design and construct a highly efficient VCSEL array on a novel topological platform optimized for reliability and scalability to large numbers of emitters, where all the emitters act as a single laser. The topological VCSEL array will be pumped electrically, operating at room temperature, and rely on quantum well optimized for emitting high power per emitter. We will define the topological insulator geometry with a reflectivity-modulation scheme that ensures reliability. Our proposed scheme, anticipated to be ready within 18 months, is scalable to a large number of VCSELs and will be a game changer in a plethora of technologies. It will pave the way to new applications that require orders of magnitude higher laser power while maintaining high coherence. It can revolutionize many applications we use in daily life.
3D Printed Fouling-Resistant Photoactive Membranes for Wastewater Treatment (PURAQUA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Portugal,Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-15
End date: 2024-09-14
Duration (months): 27.0
Total project cost (EUR): 172618.56
EU funding (EUR): 172618.56
Participants: 3
Project status: CLOSED

Conventional wastewater treatment plants (WWTPs) are not effective in removing substances from our daily basis, acting as the main release point of Contaminants of Emerging Concerns (CECs), Antibiotic-Resistant Bacteria (ARB) and Antibiotic Resistance Genes (ARGs) to the environment. Aligned with sustainable development goals, recently, the European Commission approved minimum requirements at the European level to reuse safely treated wastewater as an alternative source for irrigation to cope with water scarcity. PURAQUA aims to enhance wastewater treatment efficiency at a lower cost by developing photoactive membranes with antifouling properties, through additive manufacturing, that can be applied as a post-treatment process after the conventional WWTPs. This challenge will be tackled by: i) producing new highly active and stable photoactive catalysts; ii) preparing antifouling membranes by addictive manufacturing; and iii) designing and developing a prototype reactor for wastewater treatment at continuous flow. The proper design and fabrication of 3D printed photoactive membranes will allow the generation of reactive species at the membrane surface for the oxidation of persistent pollutants, enhancing the water permeability at higher and more constant permeate flux with an impact on the treatment cost.

Keywords: wastewater treatment processes contaminants of emerging concern membrane filtration photocatalysts additive manufacturing
Identifying Metabolic dysregulation to Guide Novel FOXP-ID/ASD Therapies (IMAGiN-IT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 2
Project status: SIGNED

The mechanisms underlying monogenic intellectual disability (ID) and autism spectrum disorder (ASD), affecting >2% of the population, remain poorly understood. Moreover, most ID/ASD syndromes are still untreatable, the exception being some disorders of metabolic origin. Therefore, identifying unappreciated metabolic mechanisms underlying the pathophysiology of ID/ASD provides a promising avenue to treatment. Several lines of evidence suggest that the transcription factors FOXP1/2/4 are ID/ASD genes with such an underappreciated role in brain (energy) metabolism: mitochondrial defects and altered metabolic rate in FOXP animal models, unpublished FoxP-/- brain transcriptome data of my host, and GWAS-based data indicating that FOXP1/2 genes are significantly associated with body mass index in the general population. Therefore, my main aim is to characterize ID/ASD phenotype-relevant metabolic dysregulation in FoxP mutants and ameliorate its effects. Powerful genetic tools in Drosophila allow me to probe specific molecular mechanisms with high spatial and temporal resolution and relate them to clinically relevant phenotypes, including locomotion behaviour habituation learning, and sleep. My objectives are to: 1) Identify phenotype-relevant metabolic target pathways of FoxP, 2) Characterize metabolic dysregulation in FoxP neurons with spatial resolution 3) Reverse behavioural FoxP phenotypes with metabolic or other innovative therapeutic interventions. This interdisciplinary approach further develops the data analyses, molecular, and imaging skills that I acquired through my PhD training and allows me to merge it with unique disease-relevant data, clinical knowledge, and collaborating networks. This project has the potential to provide novel insights into the relation of metabolism, cognition, and behaviour, and revolutionize the treatment of FOXP1/2/4 disorders. These insights may also have implications for further molecularly and clinically related ID/ASD disorders.

Keywords: intellectual disability,autism spectrum disorder,neurometabolism
Exploring the effect of seedling’s drought vulnerability on treeline dynamics under climatic change using quantitative wood anatomy (treelineQWA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Czechia
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2023-06-01
End date: 2025-12-31
Duration (months): 31.0
Total project cost (EUR): 150438.72
EU funding (EUR): 150438.72
Participants: 1
Project status: SIGNED

Global warming has modified the distribution of some forests growing at their altitudinal limit (treelines): some have been advancing (leading to loss of alpine biodiversity and changes in surface reflectance of mountain and polar areas), others remained stable leaving a lag between the position of uppermost tree stands and the treeline isotherm (TI, common seasonal mean temperature indicative for potential treeline position). Despite these striking worldwide patterns, there is a lack of systematic observation to understand the drivers of differential treeline response to global warming. The extent of the treeline lag behind warming may be associated with seedlings survival. However, as temperature is considered the main factor responsible for treeline, the role of seedling drought sensitivity as driver of differential treeline response to global warming is poorly understood. Certain xylem anatomical traits (XA) such as conduits wall thickness-area ratio, conduits area and layers, pits, and parenchyma area may confer drought adaptations, ultimately affecting survival and growth under increasing warming conditions. The proposed research will help understand the drivers of differential treeline response to global warming. I will analyse the effect of XA on the distance of the uppermost tree stands to TI in representative European treeline tree species. We will determine the treelines’ lag across several regions. I will quantify XA and their plasticity, and correlate them with treeline position. My contribution to achieve the project objectives relies on quantitative wood anatomy experience for studying drought adaptations in tree species, and examining patterns between drought resistance and anatomical variation. This project brings me experience abroad to get a permanent position at a high-quality research institution, with a high-life quality, focusing on independent research on wood anatomical influence on plant function under stressful environments.

Keywords: drought sensitivity,gymnosperms,quantitative wood anatomy,seedlings,treeline dynamics,treeline isotherm
Materials UP-cycling TO fabricate advanced MEMbrane technologies for water and food industries: towards zero waste and a circular economy (UP2MEM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Denmark,Greece,Italy,Sweden,Portugal,Slovenia,Iceland,Austria
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 4511292.84
EU funding (EUR): 4511292.84
Participants: 25
Project status: SIGNED

UP2MEM will train 15 doctoral students to face the complex challenge of predicting the impact of pollutants on the environment and water reuse as well as the recovery of valuable products in food. Therefore, the Circular Economy is used to manufacture novel filtration systems, using green approaches through four main missions: research, training, management and innovation. This objective will be achieved through a structured research training programme, which will consist of original individual research projects and education in technical and transferable skills. Experts from 11 doctoral degree-granting universities, 1 national research center and 13 companies will join forces to facilitate the successful training program that will allow doctoral students to receive an Industrial Doctorate with at least two different supervisors, one supervisor on the academy side and another on the industry side. Each research project addresses a specific topic tailored to a PhD student and will be fully integrated into a coherent research program delivered through scientific and technical Work Packages as part of an overall action plan dedicated to studying the manufacturing of membranes and filtration systems efficiently for the reuse and treatment of water and the recovery of valuable products in food. The high degree of interdisciplinarity and intersectorality of the consortium will ensure that the issue is addressed in 360 degrees and the synergy between the partners will allow addressing the fundamental ecological, biological, chemical, technological and health aspects related to the temporal evolution, management and protection of water, and food, in consideration of current and future scenarios related to climate change. Synergies and complementarities between doctoral students' projects will grow within the association, reinforced by multiple research stays and degrees with an industrial connotation, and by debates on progress and achievements during network meetings.

Keywords: water quality,nutrients recovery,circular economy,nanofiltration,polymer synthesis,catalyst design,lca,advanced ceramics,nanostructured materials,sustainable materials,eco friendly