Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Exploring the impact of anisotropic viscosity on the interplay between ice and mantle dynamics (DYNAMICE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Norway
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1499186.0
EU funding (EUR): 1499186.0
Participants: 1
Project status: SIGNED

The loss of ice mass from polar and high-elevation regions is a significant contributor to global sea level rise and affects climate and biosphere changes. Due to its importance, a better understanding of the dynamics of ice sheets is considered a priority for scientific advancement by the Intergovernmental Panel on Climate Change. DYNAMICE aims to enhance our understanding of ice sheet dynamics and ice mass loss by investigating the coupled flow dynamics of polar ice and the deforming mantle below, with a focus on the role of anisotropic viscosity for determining deformation rates. Ice and olivine, the main building crystals of ice sheets and the mantle, respectively, are two of the most anisotropic crystals on Earth. This means that individual crystals have preferred slip systems, along which it is easier to deform them. Depending on the deformation direction with respect to the mean orientation of crystals in both ice and mantle rock, the bulk viscosity can vary by a few orders of magnitude. Such variations in viscosity can greatly affect the flow of ice from ice divides to the sea, as well as the mantle’s viscous response to the unloading of deglaciated ice. As a result, spatial differences in ice texture can locally enhance or slow down ice flow, leading to some areas with faster than average ice loss and others where ice is stabilized. Moreover, in locations where ice loss is fast, and where mantle textures are favourably oriented, the viscous response of the mantle can be fast enough to uplift the ice and slow further ice loss, potentially stabilizing the ice sheet. Hence, anisotropic viscosity might play a critical role in the interplay between ice and mantle dynamics. In DYNAMICE, I will implement a framework to infer anisotropic viscosity from both ice and mantle textures in a numerical flow model. This will open new avenues for understanding solid earth and cryospheric dynamics, and their critical interactions that affect the future of Earth’s ice sheets.
Impacts of Climate Extremes from Mining of Online Texts (ICE-MOT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-04-01
End date: 2024-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Climate extremes have multifarious detrimental impacts on human activities and ecosystems. Gaining a detailed understanding of these impacts is essential for disaster risk reduction and for building resilience to extremes in a changing climate. However, current freely-accessible natural hazard databases present limitations in completeness, updateability, validation against climate data and indirect impact information. This hinders scientific and practical progress. In ICE-MOT, I aim to build a state-of-the-art impact database for extreme climate events, which overcomes the above key limitations. I will specifically combine text-mining of freely available online sources, with the use of state-of-the-art climate data. To ensure feasibility, I will initially focus on English-language texts and on wintertime cold spells in North America and windstorms and heavy precipitation in Europe – extreme events which I have studied extensively in my ongoing ERC project. ICE-MOT builds upon the database of climate extremes developed within my ongoing ERC project. It further leverages the experience of my research group in data-driven and machine learning analyses for climate science. I will use this interdisciplinary knowledge base to provide standardised, complete and automatically updateable spatio-temporal impact information, including indirect and/or cascading impacts, and quantify the climate conditions associated with the recorded impacts. Moreover, the database’s automated data extraction and processing pipeline will make it easily scalable to multiple regions and climate extremes. This effort is timely: the recent EU strategy on adaptation to climate change explicitly seeks to “gather more and better data on climate-related risks and losses” as a key adaptation tool. Moreover, the climate extremes data gathered in my ongoing ERC project provides a perfect basis to test the innovative idea underlying the ICE-MOT database, an opportunity which should be rapidly exploited.
Infectious disease outbreaks as contributors to socio-cultural transformations in the 2nd millennium BCE (PROTOPEST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499920.0
EU funding (EUR): 1499920.0
Participants: 1
Project status: SIGNED

In recent years, rapid developments in the field of ancient metagenomics, enabled through advances in genomic sequencing and ancient DNA retrieval, have provided temporal transects of microbial diversity and have paved the way for studying human-pathogen interactions, on the biological and cultural dimensions, far earlier than the written historical record. With these tools at hand, PROTOPEST will utilise a timely opportunity for investigating the impact of infectious disease epidemics on prehistoric human societies. The project will be centred on the 2nd millennium BCE, a period of large-scale socio-cultural transformations witnessed differentially across the archaeological records of Europe, Near East and Asia. Until now, studies have focused on environmental changes, economic shifts, warfare and human migration to explain these phenomena. Crucially, the 2nd millennium bears the earliest textual evidence of infectious disease epidemics ever identified, yet, their possible contribution to observed transformations, as well as their trans-regional impact beyond textual descriptions, remain largely unexplored. PROTOPEST will produce extensive ancient metagenomic, pathogen genomic and human genomic datasets, generated from human and animal remains across key regions of Europe, the Near East and Central Asia. Co-analysed alongside cultural, isotopic, paleodemographic and palaeopathological information, these data will be used to expose the unknown landscape of Middle/Late Bronze Age epidemics across a large geographical expanse. Our unique multidisciplinary framework will define indicators of prehistoric community responses to infectious disease outbreaks, and reveal how pathogens emerged and disseminated within and across human populations. In this capacity, PROTOPEST will provide a deep evolutionary and cultural framework for empirically examining the diachronic challenges that pathogens have posed on human societies, to gain a more holistic view on human prehistory.

Keywords: ancient dna,archaeogenomics,pathogen genomics,infectious disease history,prehistory,bronze age
Innovative Mechanochemical Processes to synthesize green ACTIVE pharmaceutical ingredients. (IMPACTIVE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Maintaining an innovative, sustainable and globally competitive health industry
Action type: Research and Innovation actions
Countries involved: Switzerland,France,Italy,Portugal,Netherlands,Belgium,Estonia,Germany,Ireland,Israel,Spain
Call: Green pharmaceuticals (HORIZON-HLTH-2021-IND-07, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 7665520.0
EU funding (EUR): 7438705.0
Participants: 20
Project status: SIGNED

The environmental impact of the pharmaceutical industry is a huge problem. The production and use of pharmaceuticals cause high CO2 emissions, contamination of soils, biota, and water, and even dangers to human health through carcinogenic impurities. Especially the use of solvents is a major problem. The European Green Deal has led to strict regulations on environmental pollution by the pharma industry, causing manufacturers to move outside of the EU due to the high costs associated with green pharma. This results in supply chain fragility and low crisis preparedness in Europe. New methods to produce pharmaceuticals in a green, efficient, and economically friendly way are required. The IMPACTIVE project brings together the expertise and knowledge from two COST Actions and will develop novel green methods to produce active pharmaceutical ingredients (APIs) using mechanochemistry as a disruptive technology (as acknowledged by IUPAC). Mechanochemistry uses mechanical processes, such as ball milling, twin-screw extrusion, resonant acoustic mixing, and spray drying, to induce chemical reactions. The advantages of mechanochemistry include: no solvent use, high efficiency, low costs, and reduced energy use and CO2 emission. Upon completion of the project, we will provide proof-of-concept at a small pilot scale of the use of mechanochemistry to produce 6 APIs from 3 different families of compounds. Based on a recent study, switching to mechanochemistry can reduce terrestrial ecotoxicity and CO2 emissions by more than 85%, while production costs were reduced with 12%. The results of the IMPACTIVE project will thus enable pharmaceutical manufacturers to move back to Europe while minimizing environmental pollution.Through our strong dissemination and communication strategy we will ensure that the project?s results are shared with scientists, the pharmaceutical industry, and stakeholders from regulatory and public authorities to achieve maximum impact.

Keywords: mechanochemistry,green chemistry,api manufacturing
CLImate Mitigation and Bioeconomy pathways for sustainable FORESTry (CLIMB-FOREST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Research and Innovation actions
Countries involved: Sweden,Norway,Belgium,Germany,Netherlands,Finland,Czechia,Spain,France,Poland,Switzerland
Call: Enhancing science-based knowledge on EU forests’, including old-growth forests, capacities to mitigate climate change (HORIZON-CL6-2021-CLIMATE-01, 2021)
Start date: 2022-10-01
End date: 2027-03-31
Duration (months): 54.0
Total project cost (EUR): 5360735.0
EU funding (EUR): 5360734.75
Participants: 18
Project status: SIGNED

CLIMB-FOREST suggests alternative sustainable short-, mid-, and long-term pathways for the forest sector to mitigate climate change in entire Europe, considering preservation of biodiversity, ecosystem services, bioeconomy, socioeconomic factors, use of long-lived wood products, and barriers for change. It will have long-term impact by creating attitude change in the policymaking process in the EU and influence foresters to adopt to new forest management strategies. This is accomplished through several work packages closely interrelated: We aim to 1) make a conclusive map of current forestry and management in Europe, 2) gather data and enhance process understanding of carbon uptake, sinks and other factors impacting on climate at intensively researched forest field site infrastructures, 3) quantify the bioeconomy, and customer and forest industry preferences for alternative wood products and management practices, 4) perform pan-European modelling of scenarios, and the environmental and climate impact of alternative pathways for European forestry, 5) ensure adaptation to new management strategies and forest preservation owing to intense field site visits in geographically representative locations in Europe, and 6) synthesize and disseminate the CLIMB-FOREST outcomes tailored for impact on the entire forest sector. The unique strength of the CLIMB-FOREST initiative and the potential to secure future impact, lies mainly in four crucial factors; 1) the unprecedented mapping of current forestry, management and carbon sequestration, 2) the quantification of all biogeochemical and biophysical processes in the forest, which is instrumental to the understanding of climate effects in the forest, 3) the beyond the state-of-the-art modelling that involves all socioeconomic and physical factors, and agents acting in the forest sector, and 4) the multi-actor stakeholder co-creation process generating knowledge transfer and means of change in the forestry sector.

Keywords: management,biodiversity,ecosystem service,policy,eu
Next generation environmentally friendly intraband active colloidal quantum dots and their ultrafast carrier dynamics for mid infrared photodetector (ENVINTRADOT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Infrared technology has found widespread applications across various fields, including remote controls, telecommunications networks, and thermal imaging etc. Traditional semiconductor alloys like indium gallium arsenide, mercury cadmium telluride and indium antimonide have been commonly employed as active materials in infrared devices. However, the manufacturing and assembly processes for these materials are highly complex and costly. To overcome these challenges and potentially replace expensive epitaxially fabricated devices, colloidal quantum dots (CQDs) have emerged as a promising alternative. In contemporary scientific exploration, there has been a surge of interest in narrow bandgap CQDs, thanks to their remarkable capacity to finely adjust excitonic transitions within the mid-wave infrared (mid-IR) spectrum. The discovery of intraband transition (1Se/h-1Pe/h) has opened as an alternative source of narrow energy transition occurs in the quantized conduction/valence band states of CQDs. Numerous research groups have extensively investigated the fundamental aspects and practical applications of HgE (where E = S, Se, and Te) CQDs. Leveraging numerous recent scientific breakthroughs in the domain of intraband (1Se-1Pe) active colloidal quantum dots, we will integrate state-of-the-art material processing techniques across chemistry, physics, and engineering. We will assess the dynamics of charge carriers through the utilization of femtosecond mid-IR transient absorption spectroscopy. In addition, we will focus on optimizing the required surface environment capable of maintaining intraband transitions under ambient conditions, at the same time offering adequate optoelectronic properties (mobility, conductivity) for their implementation in photodetector devices. Ultimately, our objective is to produce mid-IR photodetector devices incorporating the highly compatible non- toxic Ag2Se and core-shell CQDs.

Keywords: non toxic mid ir quantum materials,core shell qds,intraband transition,mid ir fs pump probe,auger process,mid ir photodetector fabrication,high detectivity and responsivity
Unravelling the role of extracellular nucleosomes, DNA and histones (ExNDH) in the cycle of tissue damage and neuroinflammation in stroke. (ExNDH-Stroke)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 267418.56
EU funding (EUR): 267418.56
Participants: 1
Project status: SIGNED

Stroke is associated with the death of brain tissue and is a significant cause of mortality and disability among survivors. Tissue necrosis, in addition to the active release of chromatin by activated neutrophils, a process known as NETosis, results in the release of extracellular nucleosomes, DNA, and histones (ExNDH). Such processes serve to exacerbate the initial tissue injury and promote a pro-inflammatory state, thereby amplifying the original injury. The evidence supporting this hypothesis is that the inhibition of histones, the degradation of DNA, the depletion of infiltrated neutrophils and the blocking of NETosis all result in an improvement in the outcome of stroke. While the cellular effects of ExNDH are well documented, there remain significant unanswered questions. It is yet unclear where, when, and how they arise in the extracellular space. Are they sequestered by the extracellular matrix or microvesicles? What is the fate of these substances within the vasculature and the brain parenchyma? What impact do different stroke treatment modalities have on these pathways? The objective of this project is to address these questions in vivo in a systematic manner, thereby filling a significant gap in our understanding of stroke pathophysiology. To approach these matters, I will locally express fluorescent histone protein in the brain of mice using lentiviruses, induce stroke, and track the movement of fluorescent histones using immunofluorescence analysis and two-photon microscopy. By elucidating the distinctive molecular mechanisms that disrupt the detrimental feedback loop of neuronal damage following a stroke, this research has the potential to improve patient treatment. By leveraging my extensive expertise in neuroimmunology and collaborating with the host institute at the forefront of stroke-vascular biology research, I will also be able to contribute to the evolution of new ideas and expand my scientific horizons.

Keywords: extracellular nucleosomes,dna,histone degradation,neutrophils,netosis,inflammatory response,stroke pathophysiology
Demonstration of long-endurance intelligent multi-purpose autonomous vehicles for marine applications (MERLIN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: United Kingdom,Belgium,Italy,Greece,Spain,Estonia,Cyprus,Lithuania,Denmark
Call: Novel paradigms and approaches, towards AI-powered robots– step change in functionality (AI, data and robotics partnership) (RIA) (HORIZON-CL4-2024-DIGITAL-EMERGING-01, 2024)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 7946786.25
EU funding (EUR): 7946786.25
Participants: 18
Project status: SIGNED

The importance of our seas and oceans to the economy and societal well-being is broadly acknowledged. In addition, offshore infrastructure in the form of ports, wind farms, aquaculture facilities, natural gas pipes, etc. has continuously expanded and has become more commonplace in recent years. Activities associated with seabed mapping, monitoring of the health and status of marine habitats, offshore infrastructure inspection, seabed mining and underwater sensing have traditionally been based on the use of crewed support vessels which are expensive to run and have limited endurance. The MERLIN project seeks to exploit long-endurance operational capabilities offered through the use of hydrogen fuel cells and renewable energy installed onboard Unmanned Surface Vessels (USV) and Autonomous Underwater Vessels (AUVs) which are capable of navigating and operating autonomously based on AI algorithms without the need for human intervention. A Mission Remote Control Centre (MRCC) will permit data from the autonomous vessels to be transmitted to base. Conversely, the MRCC will allow the transmission of commands from the supervisor to the robotic vehicles. The vehicles will incorporate advanced surface and underwater grasping capability for the collection of samples, handling, installation and recovery of sensors using custom-built robotic arms. The USV will provide geotagging reference data to the AUVs when they operate underwater and be able to track them during the mission. The USV will be able to navigate from its base to the location of the mission where the AUVs will be released. At the end of the mission the AUVs will dock again with the USV so they can be safely returned to base. The vehicles will be capable of operating independently as well as in combination with support vessels . The demonstration activities include three different high value use cases, including marine habitat monitoring, underwater volcano seabed mapping, and port infrastructure inspection.

Keywords: autonomous usv auv ai machine learning data management sensing automated decision making extreme environments underwater sea seabed offshore infrastructure