Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Future of Earth is Possible Through Collaboration between Scientists from Different Fields (NIGHT4FUTURE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Poland
Call: European Researchers' Night 2022-2023 (HORIZON-MSCA-2022-CITIZENS-01, 2022)
Start date: 2022-05-02
End date: 2024-05-01
Duration (months): 24.0
Total project cost (EUR): 230890.0
EU funding (EUR): 230890.0
Participants: 8
Project status: CLOSED

The NIGHT4FUTURE project aims at showing that the Earth's future is possible thanks to the constant collaboration of scientists from different fields. By implementing Researchers’ Night programme, we will show that although the climate situation of the Earth is very difficult, science gives hope for saving it. The slogan "in science there is hope" will be the main motto of the whole event. Its aim is to make young people see science as a source of strength, opportunity and hope for the future. During the event, we will show how every field of science (technical, humanities, natural, health science) can be a source of hope to save the planet. Topics will highlight the importance of the European Green Deal for Europe and its citizens. See how the super engineer of the future will be, listen to the green alarm for the Earth, trace trash in space, take part in workshops about climate change, explore the secrets of biodiversity. You will find out that scientists are ordinary people and their work is really fascinating. The NIGHT4FUTURE project is a continuation of projects from the last fifteen years, but it also presents many novelties. Module Researchers at schools, pre-events and post-events have been prepared enabling researchers and pupils to interact on societal challenges revealing the key role of research in addressing these challenges. Based on the experience of previous years we are able to modify the program and the way of organizing events in response to the changing situation in the world. Topics of individual Partners have been selected to be consistent with the overall message of the project. This year's project aims to strengthen the previous ones and shed light on new aspects of science. We want to teach young people that the work of scientists brings hope for the planet and it is a lesson worth learning from them. We want Researchers Night 2022 and 2023 to be a great celebration of science, promotion of research careers and family fun.

Keywords: researchers night education with entertainment promotion of research careers eu missions,citizens daily life societal challenges european green deal
Neuromuscular-cognitive interactions in sensorimotor decision making (MYODECISION)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Ireland
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 1499916.0
EU funding (EUR): 1499916.0
Participants: 1
Project status: SIGNED

Successfully interacting with one’s environment requires a rich interplay of perceptual judgement and neuromuscular control, with each taking account of the other in real time. Miscalculations in this accounting, as happens in demanding sensorimotor tasks (e.g. sports), cognitive and motor disorders, or with age-related decline, can have serious consequences. Despite the huge growth in modelling and neurophysiological studies of perceptual decision making, the critical role played by neuromuscular processes has been largely neglected due to challenges in parsing distinct effects of sensory, cognitive and motor processing in the brain. Our recently developed computational framework for jointly modelling behaviour with well-characterised neurophysiological signatures of sensorimotor decision formation now provides a means to overcome this parsing problem, offering a window onto the hierarchy of cortical processing involved. MYODECISION will capitalise on this advance to develop new decision paradigms that interface directly with muscle outputs, making the participants active agents in meeting changing neuromuscular demands, and hence resolve major outstanding questions regarding how sensory and motor systems interact in the brain. First, I will investigate how people adjust sensorimotor processes to meet changing time and effort demands on their motor outputs, including fine-grained manipulations of muscle-activation strength requirements, speed pressure, and effort biases. Then, using open- and closed-loop stimulus perturbations I will probe how these processes underpin dynamic changes of mind that rescue erroneous behaviours. Finally, I will develop a robust approach to neurally-constrained modelling aimed at examining individual differences in decision making in challenging sensorimotor environments. This work will offer the field a transformative paradigm for probing latent psychological processes in more ecologically representative decision scenarios.

Keywords: perceptual decision making sequential sampling cognitive neurophysiology sensorimotor behaviour
Reconstruction Biology in Plant Sciences Doctoral Training Program (rePLANT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,Portugal,Netherlands,Germany,United Kingdom,Belgium
Call: MSCA COFUND 2021 (HORIZON-MSCA-2021-COFUND-01, 2021)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1881600.0
EU funding (EUR): 1881600.0
Participants: 28
Project status: SIGNED

The rePLANT (Reconstruction Biology in Plant Sciences) Doctoral Training Program is an ambitious research and training initiative coordinated by the Centre for Research in Agricultural Genomics (CRAG; Barcelona, Spain) together with the Max Planck Institute for Plant Breeding Research (MPIPZ; Cologne, Germany) and the John Innes Centre (JIC; Norwich, UK). rePLANT is designed to conduct, and train in, interdisciplinary and intersectoral collaborative research projects between the three participating institutions, with the additional collaboration and support of associated partner organisations (private companies, and research centres and academic institutions), both national and international. The program will offer twenty (20) four-year doctoral fellowships and will be focused on: training in advanced research topics and technologies; training in non-research oriented transferable and transversal skills; collaborative research projects and secondments; and international networking in both the academic and the industrial sectors; all in order to enrich the training of the doctoral students and enhance their professional development while conducting projects of research excellence in the area of reconstruction biology in plant sciences. Reconstruction biology leverages current knowledge on plant traits and their underlying genes and molecules to understand trait diversification and innovation in a phylogenetic framework, i.e. within and between related species. rePLANT will conduct reconstruction biology at three levels of biological organisation: cell-free systems, whole organisms and ecosystems. With rePLANT, we expect to define quantitative trait models and uncover emergent properties, i.e. system features that the individual components do not have, as well as insights into how far a given trait can be diversified without pleiotropic effects.

Keywords: plant,genomes,responses to stress,metabolism,physiology,microbiology,microbiome,genetics,systems,synthetic,genomic and computational biology
Stop transmission of gambiense human African trypanosomiasis (STROGHAT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Belgium,Congo, The Democratic Republic of the,France,Switzerland
Call: Promoting implementation of research results into policy and practice (HORIZON-JU-GH-EDCTP3-2022-01, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 4001936.25
EU funding (EUR): 4001936.25
Participants: 5
Project status: SIGNED

Gambiense human African trypanosomiasis (gHAT) is a neglected tropical disease caused by trypanosome parasites. gHAT is fatal if left untreated. So far, treatment options for gHAT were limited and toxic, forcing control programs to avoid overtreatment through complex diagnostic procedures, including screening with a serological test, laborious microscopic confirmation of seropositives and lumbar puncture for disease stage determination. This resulted in loss of up to 50% of gHAT cases, which remained untreated. Recently a non-toxic single dose oral drug, acoziborole, has shown 98.1% efficacy in a phase III trial, irrespective of gHAT disease stage. Acoziborole removes the need for lumbar puncture and appears safe enough to treat serological suspects without microscopic confirmation (Screen & treat). The STROGHAT project 1° will evaluate effectiveness of a Screen & treat approach to rapidly reduce gHAT prevalence in an entire focus; 2° will extend acoziborole safety documentation; 3° and will analyze costs of this new approach. To achieve these objectives, Screen & treat will be implemented, actively and passively, for 3 consecutive years in the gHAT focus of Nord Equateur in D.R. Congo. Available geographical information will be exploited to specifically target villages where gHAT was recently, or still is present. Detection at a reference laboratory, of the trypanosomes nucleic acids in blood collected before treatment, will retrospectively identify true gHAT cases among the treated serological suspects. After 3 years of intervention, the gHAT prevalence in the focus will be re-estimated. STROGHAT intends to provide the first evidence for recommending Screen & treat to national HAT control programs for elimination of gHAT. Through facilitated diagnosis, increased acceptability and access to treatment, STROGHAT will contribute to achieving the goal of stopping gHAT transmission by 2030, as defined by the World Health Organization.

Keywords: human african trypanosomiasis,transmission,elimination,presumptive treatment,epidemiology,screening,clinical trial,drug safety,health policy
2000 Years of Subpolar North Atlantic Circulation (SNAC2K)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,Belgium,Iceland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-03-01
End date: 2026-08-31
Duration (months): 30.0
Total project cost (EUR): 244893.6
EU funding (EUR): 244893.6
Participants: 3
Project status: CLOSED

The United Nations has expressed concern over the potential weakening of the Atlantic Meridional Overturning Circulation (AMOC) in the next century, which could cause climate and weather alterations that lead to various socio-economic stresses, especially in agriculture, fisheries, infrastructure maintenance and social migration. The value of information associated with a continuous observational record of the AMOC system, which enables confident prediction of future trend, has been estimated to be tens of billions of euros. While instrumental observations of the AMOC system are only available for the last decades, we must rely on proxy indicators in natural archives to capture the long-term trend of ocean circulation throughout the Industrial Age, and further back in time when there were little anthropogenic carbon emissions. Such a long-term record is particularly important for the subpolar North Atlantic: a region of deep convection that maintains the AMOC, susceptible to freshening as a result of increasing Arctic ice melt. This project aims to develop the first comprehensive, long-term record of subpolar North Atlantic circulation through cross-disciplinary, cross-border collaboration between the French Institute for Ocean Science (host), University of Iceland (secondment), and Copenhagen University. The proposed study will compile new proxy analyses with the expanding coverage of instrumental observations to provide a confident reconstruction of the region’s hydrography and dynamics over the past two millennia. Ultimately, the project findings will be effectively delivered to the decision makers, the young generation and the general public through participation in policy works at JPI Oceans (placement), university teaching and outreach activities. The multimodal delivery of project findings aims to raise awareness of the severity of a long-term AMOC decline and to facilitate cooperation for timely mitigation of potential socio-economic consequences.

Keywords: ocean circulation sediment proxy sediment chronology tephrachronology granulometry ocean data products
TextrodeMisc – TEXtile elecTRODE Matrix for Improved Surface eleCtromyography signal quality and usability in applications for people with limb loss (TextrodeMisc)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-09-30
Duration (months): 25.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 3
Project status: SIGNED

Textile-based electrodes are about to be competitive alternatives to traditional electrodes for ECG and EMG. Electrodes integrated into textiles are easier to use which facilitates home-based monitoring, treatment and rehabilitation measures. One potential key application is Phantom Limb Pain (PLP) treatment using Phantom Motor Execution (PME), where EMG signal from the remaining muscles of the amputated limb is used to control a Virtual Reality (VR) representation of the lost limb. However, textile electrodes still need to be improved regarding electrode contact and adhesion to the skin. This calls for new sensing materials that may not have textile properties and thus need to be integrated into the textile in new ways. So, the aim of this project is to a) try new sensing materials that will improve the electrode contact and adhesion to the skin, and b) find ways to solve the interfacial linkage between the sensing material and the textile substrate. The project will focus on novel materials and textile construction development to overcome these issues. The main project deliverable is generic textile matrixes of electrodes that can be competitive alternatives to traditional electrodes. This should contribute to making e.g. PLP treatment generally available and easy to use as improved electrode signal quality would lead to better treatment effect, durability and sustainability. The concept of controlling the lost limb (central to the PLP treatment based on PME) is directly transferable to myoelectric controlled prostheses. Thus, we also aim to test what the new type of electrode matrixes could contribute to this “twin” application. The applicant's expert knowledge in sensing materials can together with smart textile experts (University of Borås), biomechatronic and pain researchers, and clinical connections (Chalmers Industriteknik) and users with limb differences make a breakthrough that addresses issues of high technical and social relevance.

Keywords: myoelectric signals,textile electrode,phantom limb pain,smart textile,skin electrode impedance,interfacial engineering,myoelectric controlled prosthesis,self administered
Personalized medicine in ovarian cancer: Design and development of a tool for response prediction to targeted platinated nanocarrier-based treatments (OvaCTool)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-16
End date: 2026-01-15
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

Personalized treatments are considered major challenges in clinical practice. They become particularly critical for diseases with poor prognoses diagnosed at later stages, such as ovarian cancer. Here, the vague symptoms, the lack of reliable screening tools and the treatment resistances have made this cancer the most lethal gynaecological malignancy (40% 5-year survival rate; 50-90% recurrence rate). Thus, ovarian cancer patients would certainly benefit from improved therapies and appropriate treatment choices. In this regard, the present OvaCTool project aims at developing a highly sensitive mass cytometer-based tool for the prediction of treatment response against newly designed targeted nanocarriers for platinum (Pt)-based chemotherapy in ovarian cancer. Specifically, diverse iron-based nanocarriers for Pt (IV) prodrugs targeting ovarian cancer cells will be evaluated. Such assessment will also include the understanding of ovarian cancer proteome changes after therapy. All this information will then be integrated to define biomarkers of treatment response which will be combined in a mass cytometry panel (up to 50 markers) together with proteins to identify other cells from the tumour microenvironment aiming at the stratification of patients into responders vs non-responders to the newly designed drugs. Likewise, protein corona formation on the nanostructures will be investigated to recognize potential challenges after intravenous injection of the drug in the clinical setting. In summary, this project will provide potential enhanced anticancer drugs and a prediction tool for targeted treatment choices which will help towards better survival rates for this malignant disease.

Keywords: ovarian cancer,platinum nanodelivery system,treatment response prediction tool,biomarkers,mass cytometry,personalized treatment
Visualization of plant Hormone dynamics using BioLuminescence during Abiotic Stress (HorLumAS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 172278.72
EU funding (EUR): 172278.72
Participants: 1
Project status: CLOSED

Live Visual Investigation of Hormonal fluxes upon Abiotic Stress in Arabidopsis using Bioluminescence
Harnessing forest genetic resources for increasing options in the face of environmental and societal challenges (OptFORESTS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: France,Finland,Slovenia,Italy,Denmark,Austria,Spain,Czechia,Romania,Norway,Germany,Switzerland,Bulgaria
Call: Protection and sustainable management of forest genetic resources of high interest for biodiversity, climate change adaptation, and forest reproductive materials (HORIZON-CL6-2022-BIODIV-01, 2022)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 8191328.75
EU funding (EUR): 8008387.0
Participants: 19
Project status: SIGNED

Forests are key elements of the European bioeconomy. To enhance provision of their ecosystem services (ES), harnessing Forest Genetic Resources (FGR) is essential. OptFORESTS will support the conservation and sustainable use of FGR by: i) conducting research on the selection of diverse forest reproductive material (FRM), including mixtures, adapted to future climates, ii) fostering sustainable use and resilience of natural forests, iii) helping expand and diversify nursery production, iv) developing nature-based solutions (NBS), tools (e.g., expanded Information Systems) and cultural trajectories to promote forest biodiversity and ES, and v) demonstrating biodiversity restoration solutions. To do this, OptFORESTS will carry out genetics, modelling, stakeholder surveys, expert panels and socioeconomic analyses. OptFORESTS will evaluate adaptive and biomass traits in existing common gardens and newly-established next-generation ones, conserve and utilise unique tree lineages for ecosystem restoration and management, model future adaptation of trees at different life stages and conduct low-input breeding. This will be complemented by studying the effects of silviculture and landscape heterogeneity on genetic diversity and developing new silvicultural options for genetically mixed forests, which will be implemented via training software (marteloscopes) and long-term demonstration plots. To enable optimal supply of diversified FRM, OptFORESTS will assess the European nursery sector, forecast future FRM needs, develop plant production technology and promote cooperation between nurseries. To ensure the uptake of NBS, they will be co-designed with local and EU-level stakeholders and a cost-benefit and gap analysis of key socio-economic, governance and policy issues will be developed. Finally, the OptFORESTS tailored communication strategy will be instrumental in achieving long-term impacts supporting international and EU policy under the European Green Deal.

Keywords: forest genetic resources,forest ecosystem services,frm provision,low input breeding,forest nurseries,sustainable forest management,forest ecosystem restoration and management,knowledge sharing