Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
EMOFACE (EMOFACE)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: France
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-06-01
End date: 2024-01-31
Duration (months): 8.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Access to health, quality education, and decent work are among the Sustainable Development Goals established by the UN member states in 2015. A key indicator for these dimensions is the development of social skills. For populations with deficits in social interaction, developing social skills is an ongoing and necessary task to ensure the well-being and social inclusion. EMOFACE offers a solution with high social impact, linking artificial intelligence technology and social skills development. EMOFACE is developing applications and training services to support autistic people throughout their lives. Our first application, Emoface Play&Learn Emotions, proposes playful activities in interaction with 3D avatars in order to train socio-emotional skills such as: recognizing the emotions of others out of and in context, expressing and managing emotions, and understanding the intentions of others. The curriculum and visual content used to illustrate emotions and social situations are adaptable to the users' needs so that our tools can accompany autistic people independently of their development and age. Our adapted design has been tested on non-verbal kids to adult autists with or without intellectual deficits. Our tools address both families and health practitioners, allowing them to easily share information about the improvement in socio-emotional skills, using our methodology that proposes objective measures in order to facilitate skill evaluation and even pre-diagnosis. Women TechEU program can help respond to the biggest challenges faced by EMOFACE in short and mid-term. The activities I plan to support with the EU grant involve operational and strategic activities in relation to international development and validation of pathway to reimbursement plans. The program would also benefit coaching from international mentors with various expertise and the access to networks of expertise for growth and expansion to international markets and busi

Keywords: autism,emotions,psycho social skills,3d avatars,ai,digital therapy,tech for good
Understanding Photodecarboxylation dynamics of Anti-INflamatory drugs (UnPAIN) (UnPAIN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 214344.72
EU funding (EUR): 214344.72
Participants: 1
Project status: SIGNED

Non-steroidal anti-inflammatory drugs (NSAIDs) are typically used to reduce inflammation, pain, and fever. However, under UV light, NSAIDs can undergo photochemical reactions in wasterwater, generating toxic radicals that threaten aquatic life and human health. UnPAIN arises as a solution to both understand and avoid this social problem. Previous spectroscopic studies have yielded inconsistent results regarding the mechanism, hindering rational design. UnPAIN will provide time-resolved chemical information to answer some fundamental questions such as the difference in photostability, considering both structural and environmental factors, bringing together advanced quantum chemical methods and computational simulations in the excited state for some representative NSAIDs such as ketoprofen, tiaprofenic acid, suprofen, naproxen and ibuprofen. This challenge includes dealing with multiple electronic states, internal conversion, intersystem crossing, and accurately describing anionic systems and solvents. The knowledge gained from this research could lead to safer drug designs and more stable formulations. Simultaneously, UnPAIN is designed to establish a robust protocol for studying in a general way photodissociative processes, which will be extremely useful for the scientific community. The experienced researcher will share knowledge on non-covalent interactions, and reaction mechanisms to the host group, while acquiring expertise in emerging quantum chemical methods and time-resolved chemical phenomena. UnPAIN will equip the applicant with the foundation needed to pursue an independent career, fostering a unique and highly competitive research profile. Additionally, it will offer excellent training, an enhanced scientific network, and a comprehensive set of essential soft skills, including communication, management, dissemination, and public engagement.

Keywords: ab initio excited state dynamics simulations,theoretical spectroscopy
The Path Towards Addressing Adverse Impacts of Light and Noise Pollution on Terrestrial Biodiversity and Ecosystems (PLAN-B)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Belgium,Brazil,United Kingdom,Poland,Germany,Spain,Sweden,Switzerland
Call: Impact of light and noise pollution on biodiversity (HORIZON-CL6-2023-BIODIV-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 2373952.5
EU funding (EUR): 2373952.5
Participants: 12
Project status: SIGNED

The rate of global biodiversity decline is unprecedented and accelerating. Urban sprawl, population growth and industrialization bring previously unrecognised drivers of biodiversity loss, including light and noise pollution. The EU has adopted policies, including the EU Green Deal and the EU Biodiversity Strategy for 2030, to enable transformative change through better protection of biodiversity and nature restoration activities. However, current projections suggest that the EU’s 2030 biodiversity target will not be met; an alternative plan is required. PLAN-B takes an integrated, multidisciplinary and multi-actor approach to deliver better understanding and support reduction of light and noise pollution impacts on terrestrial biodiversity and ecosystem services. Key outputs of PLAN-B include: a framework and supporting handbook for assessing light and noise pollution impacts to inform environmental decision-making; an open access database on light and noise impacts on terrestrial biodiversity; spatiotemporal models for evaluating noise and light impacts on terrestrial biodiversity and ecosystem services, including at the European scale; innovative solutions to prevent and mitigate light and noise pollution impacts; recommendations for enhancing legal and policy frameworks to reduce light and noise pollution impacts on terrestrial biodiversity; and sustainable Communities of Practice (CoPs), centred around key stakeholder groups, on the impacts of light and noise on terrestrial biodiversity. Working with European and international partners, including from Brazil, CoPs, key networks (e.g. Biodiversa+) and the Horizon Europe sister project on aquatic biodiversity and ecosystems, PLAN-B will maximise its global reach and research impact. Through its work programme, PLAN-B will create the enabling conditions to support and enhance activities planned in the EU biodiversity strategy and provide a new path towards meeting the EU and international biodiversity targets.

Keywords: light pollution noise pollution biodiversity conservation impact assessment
Next-generation membrane technologies for sustainable exploitation of seawater brine resources: transition towards a circular blue industry (EXBRINER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,France,Denmark,Belgium,Spain,Czechia,Portugal,Germany
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 2617264.8
EU funding (EUR): 2617264.8
Participants: 15
Project status: SIGNED

The MSCA-DN programme “EXBRINER/Next-generation membrane technologies for sustainable exploitation of seawater brine resources: transition towards a "circular blue industry” is designed to train a new generation of doctoral candidates in Membrane Engineering by means of a synergic cross-fertilization of complementary competences centered on the development of innovative membrane technologies at water-energy-resources nexus for a sustainable valorization of desalination wastes. The doctoral programme is implemented through an inter-sectoral and multidisciplinary Network, composed by 8 Universities, 3 Research Centers and 4 Industrial Companies (two of them are SMEs) from 8 European Countries, all with recognized excellence in the field of membrane technology. Based on more than 10 years of joint experience in Erasmus Mundus Joint Doctorate/Master in Membrane Engineering, the Consortium shares a common infrastructural platform - with worldwide recognized excellence - for implementing highly competitive and jointly supervised training and research activities. Those activities, oriented towards societal needs of strategic relevance for the European Union, cover a large spectrum of “market-relevant” applications such as: sustainable desalination for water supply, exploring alternative mineral sources for a secure supply of critical raw materials, low-carbon power technologies based on Salinity Gradient energy.

Keywords: membrane science and technology blue economy,zero liquid discharge,critical raw materials
OPENing biological barriers using Shell-Engineered Shape-Adaptable Microbubble Enhancers (Open-SESAME)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-10-01
End date: 2027-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

OPEN-SESAME will assess the technical and commercial feasibility of a modular microbubble platform technology to enhance the delivery of drugs across biological barriers. The project aims to: (i) establish a robust and scalable synthesis protocol for producing shell- and shape-optimized polymeric microbubbles; (ii) evaluate the preclinical performance of our ultrasound-responsive microbubble enhancers in brain and tumor mouse models; (iii) strengthen our intellectual property (IP) position through freedom-to-operate investigation and generation of new IP on microbubble functionalization; (iv) consult key opinion leaders and perform market analysis of the drug therapy enhancer landscape; and (v) consolidate results in an investor-ready business plan to guide the commercialization of our microbubble platform. We anticipate that by exploiting the technological and socio-economic potential identified in the OPEN-SESAME project, we will create completely new opportunities for the use of microbubbles plus ultrasound to enhance drug delivery and improve therapy outcomes in patients suffering from high-medical-need diseases.
Learning from Experience and Agency in Displacement (LEAD): Building a Refugee-led Approach to Displacement Justice (LEAD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1579270.0
EU funding (EUR): 1579270.0
Participants: 1
Project status: SIGNED

Both in political and academic conversations, refugees are often spoken about but rarely spoken to. Refugees, of course, often discuss displacement justice with their own communities in response to their personal experiences and expertise, and with charities and agencies with whom they interact. But politicians, policymakers, and philosophers alike do not often have experience of displacement and fail to include those who do. Because of this, philosophers lack the resources to develop a fully comprehensive account of what justice for refugees might require. The LEAD project aims to critically develop the theoretical and methodological tools for a refugee-led approach to displacement justice. In recent years, literature in refugee studies and the ethics of migration has begun to reflect on refugee agency. This work highlights how displaced people respond to their difficult circumstances and emphasises the importance of choice and autonomy. This “agential turn”, which is present throughout social and political philosophy more widely, aims to centre the perspectives of marginalised groups. However, such work often stops short of including displaced people in the project of theory building itself. We can therefore ask: what would a refugee-led approach to theorising about displacement justice look like? The project will include people with experience of displacement not only in testing this methodology but also in critically building it throughout the research programme. The novelty of this project is three-fold. First, the LEAD project will integrate lessons from refugee and forced migration studies into the ethics and political philosophy of displacement. The project therefore attempts to build bridges between these two disparate literatures. Second, the project will radically expand our ideas of who “counts” as an interlocutor in philosophical discussions by substantively collaborating with refugees and refugee-led organisations in the project of theory building.
(Re-)Writing the Ubiquitin Code – Manipulating Polyubiquitin Chain Linkage to Investigate Ubiquitin Signalling in Genome Maintenance and Beyond (UBICODEWRITERS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2499799.0
EU funding (EUR): 2499799.0
Participants: 1
Project status: SIGNED

Ubiquitylation is an essential posttranslational modification that governs the activities and interactions of cellular proteins. The structural diversity of polyubiquitin chains, collectively called the ‘ubiquitin code’, is thought to determine the fate of the modified proteins. Although many analytical and inhibitory ubiquitin-specific reagents exist, we lack the tools to create polyubiquitin chains of defined linkage on a protein of interest in cells to investigate their signalling functions. We recently established a method to induce substrate-specific polyubiquitylation via three major linkages, M1, K48, and K63. Based on this technology, we now propose to develop a new generation of research tools for the scientific community. This will include the identification and design of custom enzymes for assembling the rarer, still poorly characterised non-canonical linkages and a functionalisation with modules for chain editing, branching, and the identification of effectors. In a combination of biochemical, cell biological, and proteomic approaches, we will then apply these tools to major genome maintenance pathways with prominent roles in the defence against disorders such as cancer and premature ageing. Specifically, we will analyse the significance of non-canonical polyubiquitylation in the response to DNA double-strand breaks and the interplay between degradative and non-degradative ubiquitylation in the regulation of essential DNA replication and repair factors. We envision that our research will not only provide new insight into ubiquitin signalling in genome maintenance, but the new technology developed in this project will facilitate future investigations of polyubiquitin chains, their readers, and their writers in other signalling pathways. Situated at the interface between proteostasis and genome maintenance, this project will thus advance our understanding of two essential cellular surveillance systems with critical functions in human health and well-being.

Keywords: ubiquitin,polyubiquitin chain linkage,proteostasis,genome stability,dna repair,dna double strand breaks,dna replication stress,dna damage signalling
Health virtual twins for the personalised management of stroke related to atrial fibrillation (TARGET)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Spain,Belgium,France,United Kingdom,Sweden,Austria,Greece,Romania,Germany,Netherlands
Call: Integrated, multi-scale computational models of patient patho-physiology (‘virtual twins’) for personalised disease management (HORIZON-HLTH-2023-TOOL-05, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 7008941.25
EU funding (EUR): 7008941.25
Participants: 22
Project status: SIGNED

Atrial fibrillation (AF) is the most common heart arrhythmia worldwide, leading to life-limiting complications, high financial burden and significant resource utilisation. In Europe, stroke as a debilitating complication of AF, is amongst the commonest causes of death and the leading cause of disability. AF patients have a 5-fold increased risk for ischaemic stroke. Functional recovery from AF-related stroke (AFRS) is often unsatisfactory, leading to severe disability, reduced quality of life and high mortality. TARGET’s ambition is to develop novel personalised, integrated, multi-scale computational models (virtual twins) and decision-support tools for the AF-related stroke pathway, starting from the healthy state, pathophysiology and disease onset, progression, treatment and recovery. TARGET aims to help prevent AF and AFRS, optimise acute management and rehabilitation, reduce long-term disability, provide a better quality of life for patients and caregivers, and lower healthcare costs. We will ensure patients are at the heart of the project, and the association with experienced commercial partners will ensure the swift adoption of TARGET’s novel technologies. New observational data will be collected via 4 carefully designed prospective clinical studies, which will be used to test and validate the personalised tools and the virtual twin models using a clinical trial simulation (virtual/in-silico), to demonstrate evidence of clinically meaningful results. TARGET will also help consolidate existing mechanistic virtual twin models of the heart, the brain and the neuromusculoskeletal system, enriching these twins to deliver more complex tasks, and supporting research to move towards a more integrated human virtual twin. TARGET represents a milestone project to improve the care and rehabilitation of patients with AF and AFRS, introducing a paradigm shift in risk prediction, diagnosis and management of the disease, and accelerating translational research into practice.

Keywords: virtual twins,stroke,atrial fibrillation,rehabilitation,stroke care pathway,artificial intelligence,in silico trials,simulated trials
Optical Front-Haul Communications Links based on Reflective Semiconductor Optical Amplifier Transmitters for Next Generation Radio-over-Fiber 5/6G Mobile Systems (SOAT-NG)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 1
Project status: SIGNED

Colourless optical transmitters provide compact and economic designs to develop optical front-haul network technologies for future mobile and general wireless networks. Semiconductor Optical Amplifiers (SOAs) have great potential in realising efficient colourless transmitters as they can simultaneously provide amplification and modulation capabilities. This project will exploit Reflective SOA (RSOA) based colourless transmitter designs to integrate efficient and cost-effective Radio over Fiber (RoF) systems. The RSOAs feasibility to integrate developed technologies like Wavelength Division Multiplexing-Passive Optical Network (WDM-PON) for next generation access networks will be addressed. The project will carry out RSOA/system modelling and experimental evaluation of several designs focusing on multi Gigabit/per second data transmission through the use of advanced modulation formats in particular as 16-level Pulse Amplitude Modulation (16-PAM). The designed systems will employ and compare two seeding schemes to optically feed RSOA; external light seeding with coherent light source and broadband seeding. Transmission system performance will be evaluated particularly in terms of received signal constellation properties and Bit Error Rate (BER). The impact of RSOAs in such systems will be studied in detail to decide the optimal RSOA operating parameters such as its bias and modulation currents and input optical power. The work will address challenges that impact SOA performance in WDM-PONs, such as the influence of SOA non-linearities and noise. The proposed research will aid the design of novel RoF systems that can support future 5/6G infrastructure. The project will be implemented in a leading multi-disciplinary research group and the researcher will bring modelling and advanced experimental hands-on experiences that will facilitate research in the group

Keywords: semiconductor optical amplifier,reflective semiconductor optical amplifier,radio over fiber,wdm pon,mobile front haul,5 6g infrastructure