Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Can histone code-like switches govern the multifunctionality of RNA-binding proteins? (MARS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Post-transcriptional control of human gene expression is conferred by >1000 mRNA-binding proteins (RNA-BPs), which determine the utilisation and fate of mRNAs, with the aetiology of a wide-range of disorders (e.g. neurological, inflammatory, and neoplastic) being due to their dysregulation. Multifunctionality is a feature of RNA-BPs and understanding how this is coordinated and regulated is pivotal to delineating the molecular circuitry of post-transcriptional gene regulatory networks, to understand why they go wrong and how they may be manipulated. Poly(A)-binding proteins (PABPs) are central multifunctional regulators of mRNA fate, controlling multiple aspects of mRNA translation, stability and quality via interacting with functionally diverse protein partners. Consequently, their deficiency impacts physiological processes such as gametogenesis, metabolism and learning/memory, although mechanistic bases of these phenotypes are unclear, highlighting the importance of understanding their functions and regulation. A key gap in our knowledge is how PABP protein interactions, and therefore functions, are coordinated since many of its partners bind the same “PABC domain” site, through a shared “PAM2” motif. However, our recent findings lead to a novel hypothesis, which I will address, namely that the post-translational modification (PTM) status (acetylation or dimethylation) of a functionally important PABC residue, K606, determines PAM2-partner binding specificity and PABP multifunctionality. Uncovering that “histone-code like” acetylation-methylation switches operate in RNA-BPs, to coordinate their functions and achieve post-transcriptional regulation of mRNA networks, would represent a step-change in the state-of-the-art. This is especially timely since acetylations/methylations are emerging from proteomic studies as common in RNA-BPs and thus, PABP may provide an important paradigm for understanding how these PTMs coordinate post-transcriptional control.

Keywords: pabpc1,pabp1,pam2,rna binding protein,post transcriptional control,post translational modification,mrna translation,mrna stability,lysine acetylation,lysine methylation,micro rna
Sex differences in expression in the shared genome (SexDiff)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-01
End date: 2019-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Males and females in many animals are strikingly different in behaviour, physiology, shape and form. In humans, rates of ageing and disease incidence vary markedly between the sexes. Moreover, sex differences in response to medical therapies and treatments have recently become an area of major biomedical concern. Because there are very few sex-limited genes, sex differences are largely a product of contrasting gene expression patterns between males and females4. Despite their ubiquity and clear biomedical importance, the evolutionary causes of sex differences in gene expression remain essentially unknown and pose a fundamental problem for biologists: How do sex differences evolve given that the sexes largely share the same genome? My research addresses this fundamental question using two approaches: (1) a data-driven, large-scale phylogenetic approach, and (2) an experimental manipulation of chromosome dose in Drosophila melanogaster. The results from this project will create comprehensive understanding of sex-specific gene regulation and evolution. This broad research has important implications for medical, developmental and evolutionary studies of sex differences and addresses a key aim, as identified by the European Commission, for research excellence in Horizon 2020.

Keywords: sexual dimorphism,sexual selection,evolutionary biology,sex chromosomes
a Federated Artificial Intelligence solution for moniToring mental Health status after cancer treatment (FAITH)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Spain,Ireland,Ireland,Italy,Cyprus,Portugal
Call: Big data and Artificial Intelligence for monitoring health status and quality of life after the cancer treatment (H2020-SC1-DTH-2019, 2019)
Start date: 2020-01-01
End date: 2024-06-30
Duration (months): 54.0
Total project cost (EUR): 4831233.75
EU funding (EUR): 4831233.75
Participants: 10
Project status: SIGNED

The main aim of FAITH is to apply the latest Artificial Intelligence (AI) and Big Data analytics techniques to better model and predict disease/treatment trajectories of cancer patients, with the goal of improving their quality of life and aftercare. To protect privacy of the individual, but still gain insights that are beneficial to the broader population, FAITH will be applying the concept of federated machine learning, which makes it possible to build machine learning systems without direct access to personal treatment data that will be used for training in machine learning. Devices private to the patient will run their own personalised AI models, via the project’s ‘AI Angel’ application, while a global AI model aggregates the individual model learnings (rather than the traditional approach of a central repository of holding all private patient data). FAITH’s ‘AI Angel’ will remotely analyse depression markers, predicting negative trends in their disease trajectory, giving their healthcare providers advanced warnings to allow for timely intervention. These markers are treated under several distinct categories: Activity, Outlook, Sleep, and Appetite, in accordance with the 3M strategy for population health: Monitor–Measure–Manage. Central to the vision of the FAITH project is to measure population health deeply, it is necessary to monitor individuals on a continuous basis to cast a wide enough net over a user’s health data. A key strength of FAITH is the involvement of eminent cancer hospitals and specialists in the consortium to provide relevant applicable cancer care related use cases that can effectively leverage a big data framework using computational intelligence approaches and methodologies that can be used for long term cancer care health risk and symptom minimisation for patients. FAITH has trial sites in Madrid, Waterford, and Lisbon, with real end users to assess and validate the adoption and usage of the FAITH technologies and platform.

Keywords: lightweight ai,federated learning,activity tracking,monitor measure manage,mental health
Twinning for reaching sustainable scientific and technological excellence in the field of Green Electronics (GREENELIT)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Italy,Serbia,Denmark
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2020-11-01
End date: 2023-10-31
Duration (months): 36.0
Total project cost (EUR): 898800.0
EU funding (EUR): 898800.0
Participants: 3
Project status: SIGNED

This project proposal aims at significantly strengthening research and innovation capacities of the University of Novi Sad (UNS), Serbia in the emerging field of Green Electronics by twinning action with EU internationally-leading research institutions – Italian Institute of Technology (IIT), Italy and Technical University of Denmark (DTU), Denmark. Through this project, networking gaps and deficiencies between the UNS and EU leaders will be decreased as well as RDI capacity of the involved institutions will be enhanced and staff’s research profile will be improved. Green Electronics or Food-based electronics or electronic devices which can be consumed through the digestive system, provides solution for continuous monitoring of physiological parameters of the human body and represents alternative for invasive and painful approaches in conventional medicine. The GREENELIT work program envisages: (1) Sustainable linking for excellence - through transfer of knowledge and expertise during secondments, best practices will circulate between UNS and EU leading research institutions (IIT and DTU); (2) Raise research profile of the UNS and its staff - through delivering lectures by experts, short-term on-site training, organization of workshop/conference and strengthening the research management and administration unit at UNS; (3) Scientific strategy for stepping up in the field of Green Electronics - through benchmarking analysis and creating the Strategy and Action plan for its implementation; (4) Involvement of early stage researchers - focused on promotion of involvement of ESRs at UNS and improvement prospects of their career through training, mentoring and networking measures; (5) Dissemination and outreach activities - aimed to present the GREENELIT achievements to a wider community. This project will significantly support the UNS on the route to be a dynamic "innovation engine" capable of sustaining regional and national scientific, economic and social growth.

Keywords: green electronics,food based electronics,biocompatible electronics,bioresorbable electronics,biodegradable electronics
Green and Straightforward process for the synthesis of Graphene based-nanomaterials for energy applications (GRAPHEEN)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

GRAPHEEN project aims at scaling up a green, affordable and straightforward process for the industrial synthesis of graphene-based materials for their use as new electrode materials in higher performance electrochemical energy storage devices: lithium ion batteries and supercapacitors. Lithium Ion batteries (LIBs) are currently dominating the energy storage market, as they are to date best performing devices in terms of energy storage capability (energy density). However, LIBs are still facing challenges because they lack of a high power density, meaning these devices have long charging/discharging cycles. This issue is especially important in view of efficiently exploiting renewable energies and especially for supplying the required energy to power electric vehicles (when high energy inputs are required in a very short time). As alternative, supercapacitors emerge as alternative to Lithium Ion batteries because these devices can provide high energy inputs in just a matter of seconds because of their high power density. Nevertheless, in contrast with LIBs, supercapacitors cannot accumulate enough energy to supply during a long time (they have a low energy density). For these reasons, supercapacitors and LIBs are being used as complements one of each other in those highly energy demanding applications. In view of the rapid market entrance of electric vehicles and the big pressure towards using alternative energy sources to fossil fuels, the energy sector is facing an increased need for solutions to enhance the power density of LIBs and to improve the energy density of supercapacitors. The solution to achieve these improvements is the development of new and better performing electrode materials, as the performance of electrochemical devices mostly relies on the properties of the electrodes integrating them.

Keywords: graphene,supercapacitors,batteries
Film Colors. An Interdisciplinary Approach. (Filmcolors)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-09-01
End date: 2021-05-31
Duration (months): 69.0
Total project cost (EUR): 2913143.75
EU funding (EUR): 2913143.75
Participants: 1
Project status: CLOSED

Film is in essence colored light projected onto a screen. Its aesthetics are thus highly determined by the material properties of film and the optical configuration of the cinematic apparatus. To this day, however, there is no systematic study of the relationship between the technology and aesthetics of film colors, despite the fact that, following the digital turn in film production and distribution, the understanding of this relationship is more essential than ever before. Over 200 film color processes were developed since the invention of film. They are presented on the Timeline of Historical Film Colors, which will be an integral part of the project. The groundbreaking nature of this project lies in a truly interdisciplinary research design with a novel methodology to explore the interaction of technological advances and limitations with film color aesthetics, identifying diachronic patterns of stylistic means. To this end it develops a tool through recent advancements in digital humanities for crowd-sourcing of color analyses of large groups of films. In-depth studies of technical papers and scientific measurements of film colors will investigate the technical basis of films’ aesthetic appearance. These insights will be applied to the digitization and restoration of historical films to explore and disseminate the results. While every serious art restoration connects scientific analyses with art-historical and aesthetic investigations, a similar approach is rarely applied to film. In summary, the present research proposal capitalizes on the principal investigator’s preceding studies to bridge the gap between technology and aesthetics. With the methods described here, the results will trace previously hidden roots of aesthetic developments of film colors. While the project is ambitious, it builds on a sizable methodological foundation to optimize risk management and guarantee significant advances in the understanding of film colors.

Keywords: film,film history,film technology,film narration,film aesthetics,film analysis,film perception,digital humanities
The role of regions in the European Bioeconomy - Bratislava Bioeconomy Conference 2016 (BBEC2016)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Coordination and support actions
Countries involved: Slovakia
Call: Bioeconomy Presidency Conference: Innovating for Sustainable Growth: a Bioeconomy for Europe (H2020-IBA-SC2-PRESIDENCY-2016, 2016)
Start date: 2016-09-27
End date: 2017-01-26
Duration (months): 4.0
Total project cost (EUR): 145000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The main objective of the project is to organize the international conference “Bratislava Bioeconomy Conference 2016” during the presidency of the Slovak Republic in the second half of 2016, disseminate its outcomes and to prepare the discussions for the Agriculture and Competitiveness Council meetings based on the outcomes of the conference. The aim of the conference is to discuss with national and regional stakeholders the new bioeconomy context for the agriculture, forestry and fisheries, the role of research and innovation to overcome the big societal challenges ahead of us and also to identify the barriers in the regions in adapting the bioeconomy strategy. The proposed Slovak Presidency “2016 Bratislava Bioeconomy conference” will provide an occasion to have high-level discussions on sustainable bioeconomy, strategies and actions. The aim is to create a programme that will provide a forum for stakeholder across the whole bioeconomy value chain to discuss the progress of the bioeconomy. The conference will not provide just a summary of the current state of matters, but will be forward looking by creating new policy ideas, catalysing joint initiatives and research and searching synergies among existing actions, projects and initiatives. The programme will be carried by top-level speakers from various fields, academia, and business and the concept and first draft of the conference programme was created by group of national and international experts, representatives of stakeholders and representatives of public institutions. Attention will be paid to post conference activities including policy seminars and policy briefings in order to achieve better implementation of the bioeconomy strategy in European regions.

Keywords: sustainable production,renewable resources,bio based products,bio energy,bioeconomy,presidency event,slovakia
Cell-free Ti-based Medical Implants due to Laser-induced Microstructures (CellFreeImplant)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Austria,Germany
Call: FET Innovation Launchpad (H2020-FETOPEN-4-2016-2017, 2017)
Start date: 2018-07-01
End date: 2019-12-31
Duration (months): 18.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 3
Project status: CLOSED

New miniaturized and smart medical implants are more and more used in all medical fields, including miniaturized pacemakers. These implants with a casing consisting often of a Ti-alloy may have to be removed after some months or several years and shall therefore not be completely overgrown by the cells. In the framework of the ongoing FET Open project LiNaBioFluid, we successfully demonstrated that self-organized sharp cones or spikes at Ti-alloy substrates created by pulsed laser-ablation can result not only in complete wetting by water and body fluids but at the same time provide too little surface for the cells (i.e., fibroblasts) to grow on. Compared to flat surfaces, the cell density on the microstructures is significantly lowered, the coverage is incomplete and the cells have a clearly different morphology. The best results regarding suppression of cell growth are obtained on structures created by femtosecond Ti:sapphire laser irradiation, which are subsequently electrochemically treated. The goal of the Coordination and Support Action CellFreeImplant is to find strategic partners (end-users) for future development of smart medical implants addressing wide-spread patients needs for instance in the field of cardio-vascular diseases. The project activities include the identification of the market segments and needs and assessment of the technology with end-users.

Keywords: cell repellent surfaces,medical implants,laser induced microstructures,electrochemical oxidation
INnovative Training in Myeloid Regulatory Cell Therapy (INsTRuCT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Ireland,Germany,Italy,Spain,Spain,Germany,Belgium,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-01-01
End date: 2024-06-30
Duration (months): 54.0
Total project cost (EUR): 4004719.36
EU funding (EUR): 4004719.3600000003
Participants: 15
Project status: SIGNED

Cell therapy is an active area of immunological research and represents a highly innovative and rapidly expanding sector of pharmaceutical industry. The INsTRuCT Consortium answers an unmet need in the field for postdoctoral researchers experienced in scientifically excellent research and cell therapy development. INsTRuCT draws upon complementary expertise of its academic and industrial partners to offer a unique research and training programme. INsTRuCT proposes 15 distinctive research projects based at European companies or universities recognized for their scientific achievements and innovation. INsTRuCT is structured to promote interdisciplinary and intersectoral cooperation between partners, thereby accelerating pharmaceutical development and clinical application of novel myeloid regulatory cell (MRC)-based therapies. INsTRuCT is a primarily research-based training programme, which will be complemented by theoretical and practical training opportunities. INsTRuCT will encourage a translational view of research, which will be reinforced by intersectoral secondments. Teaching transferrable and communication skills is a high priority for INsTRuCT. ESR will gain a comprehensive overview of the drug development process in Europe as it applies to cell-based therapies; hence, INsTRuCT’s graduates will be fitted for future roles as innovative leaders in the field. INsTRuCT will strengthen interactions between cooperating research groups at junior and senior levels, thereby promoting dissemination of standardized research approaches and data-sharing. Overall, INsTRuCT constitutes an original research and training concept that responds to the specific needs of a growing sector for postdoctoral scientists trained in Basic Immunology and cell therapy development. Consequently, INsTRuCT has a very high impact potential, both in terms of its scientific and technical advancements, and its future contribution to innovation and economic development within the European Union.

Keywords: cell based therapy,atmp,solid organ transplantation,immunological regulation,mononuclear phagocyte,dendritic cell,macrophage,pharmacokinetics,pharmacodynamics