Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Accessible, Impactful, Measurable and Socially responsible tutoring (AIMS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-04-01
End date: 2015-07-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Growing competition for top schools and highly qualified roles has driven growth in demand for tutors in the EU and globally (FT, 2013). However, tutoring remains unregulated, without mechanisms to measure performance and over-reliance on referrals (NEESE, 2011), and high transaction costs which price many schools and families out of the market. Tutorfair is a marketplace to help schools and parents find great tutors and, for every student who pays, they give tutoring to a child who can't afford it. Tutorfair has proven the concept of a full lifecycle platform for the tutoring sector which is open, disruptive and innovative: • For tutors, AIMS makes it easier to start and build their business, with opportunities for networking, training and observations to continue development; • For clients, AIMS makes it easier to find good tutors in a transparent and fair way; • For the industry, AIMS opens up access to industry wide accreditation and collaboration; and • For society, Tutorfair brings a one-for-one promise to give tutoring to children who can't afford to pay. The results of this project will meet objectives for the Open Disruptive Innovation theme by creating a new paradigm on the fast-growing private tuition market, lowering barriers to entry, empowering local agencies and widening access. With support from the SME Instrument Phase 1, Tutorfair will undertake a technical feasibility and commercial viability assessment of AIMS in the EU28, testing the likelihood of commercial success and potential impacts, on this €14Bn market. Tutorfair’s 15-strong team aims to make tutoring accessible to everyone, impactful, measurable and socially responsible. With 50yrs of combined experience ommercializing results of R&D for companies incl. LOVEFILM, Sainsbury’s, Procter & Gamble, Zyb and PutITout, the Tutorfair team is well placed to exploit the outcomes of this innovative project and make the growth of tutoring good for everyone.

Keywords: tutoring,education,learning,marketplace,accessibility,openness
Searching for The Origin of Cosmic Rays and Neutrinos with LOFAR (LOFAR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-06-01
End date: 2020-11-30
Duration (months): 66.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

The origin of cosmic rays remains one of the largest mysteries in astrophysics. Innovative and accurate radio measurements of cosmic rays and neutrinos with LOFAR promise to provide new answers. It is generally believed that ultra-high-energy cosmic rays are produced in extragalactic sources like gamma- ray bursts or active galactic nuclei, while the lower energy cosmic rays come from our own Galaxy. At what energy this transition takes place is still unknown. Here we focus on disentangling Galactic and extragalactic components by studying the mass composition between 10^17 and 10^18 eV, a regime that is also crucial for understanding the origin of the extraterrestrial neutrinos detected by IceCube. We do this with LOFAR, the first radio telescope that can detect individual cosmic rays with hundreds of antennas. This incredible level of detail allowed us to finally understand the complicated radiation mechanism and to perform the first-ever accurate mass analysis based on radio measurements. Our first data reveal a strong proton component below 10^18 eV, suggesting an early transition to an extragalactic component. With upgrades to our detector and techniques we will be able to improve our sample size by an order of magnitude, resolve more mass components, and identify the origin of high-energy cosmic rays and neutrinos. The technique may be scaled up to higher energies, measured at the Pierre Auger Observatory, where mass information is needed to correlate cosmic rays with their astrophysical sources and to confirm the nature of the cutoff at ~10^19.6 eV. We can even search for particles beyond the GZK limit. With the Westerbork telescope we have already set the best limit on cosmic rays and neutrinos above 10^23 eV. With LOFAR we will achieve a much better sensitivity at lower energies, also probing for new physics, like the decays of cosmic strings predicted by supersymmetric theories.

Keywords: radio detection of cosmic rays and neutrinos
Enabling Precision Immuno-oncology in Colorectal cancer (EPIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Austria
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 2460500.0
EU funding (EUR): 2460500.0
Participants: 1
Project status: SIGNED

Immunotherapy with checkpoints blockers is transforming the treatment of advanced cancers. Colorectal cancer (CRC), a cancer with 1.4 million new cases diagnosed annually worldwide, is refractory to immunotherapy (with the exception of a minority of tumors with microsatellite instability). This is somehow paradoxical as CRC is a cancer for which we have shown that it is under immunological control and that tumor infiltrating lymphocytes represent a strong independent predictor of survival. Thus, there is an urgent need to broaden the clinical benefits of immune checkpoint blockers to CRC by combining agents with synergistic mechanisms of action. An attractive approach to sensitize tumors to immunotherapy is to harness immunogenic effects induced by approved conventional or targeted agents. Here I propose a new paradigm to identify molecular determinants of resistance to immunotherapy and develop personalized in silico and in vitro models for predicting response to combination therapy in CRC. The EPIC concept is based on three pillars: 1) emphasis on antitumor T cell activity; 2) systematic interrogation of tumor-immune cell interactions using data-driven modeling and knowledge-based mechanistic modeling, and 3) generation of key quantitative data to train and validate algorithms using perturbation experiments with patient-derived tumor organoids and cutting-edge technologies for multidimensional profiling. We will investigate three immunomodulatory processes: 1) immunostimulatory effects of chemotherapeutics, 2) rewiring of signaling networks induced by targeted drugs and their interference with immunity, and 3) metabolic reprogramming of T cells to enhance antitumor immunity. The anticipated outcome of EPIC is a precision immuno-oncology platform that integrates tumor organoids with high-throughput and high-content data for testing drug combinations, and machine learning for making therapeutic recommendations for individual patients.

Keywords: cancer immunology,combination therapy
Fundamentals of Biological Ice Nucleation (F-BioIce)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-04-01
End date: 2025-03-31
Duration (months): 72.0
Total project cost (EUR): 1999936.0
EU funding (EUR): 1999936.0
Participants: 1
Project status: SIGNED

Ice active bacteria can promote the growth of ice more effectively than any other material known. Using specialized ice nucleating proteins (INPs), they attack plants by frost damage and, when airborne in the atmosphere, they drive ice nucleation within clouds and control global precipitation patterns. The control INPs exert over water phase transitions has relevance for disciplines as diverse as climatology, plant pathology, biomedicine and material science. Despite the apparent importance, the molecular mechanisms behind INP freezing have remained largely elusive. This lack of our knowledge can be traced back to the challenges in studying protein and water structure and dynamics at the very interface between monolayers of proteins and water. With F-BioIce my team and I want to reveal the molecular details of INP function. We ask the questions: What is the structural basis for protein control of freezing? What structural motifs do proteins use to interact with water, and what is the configuration of water molecules that INPs imprint into interfacial water layers? What is the role of structural dynamics and for surface freezing? We will develop new methods based on sum frequency generation (SFG) spectroscopy to determine mode of action by which INPs interact with and manipulate water. The INPs and water structure will be obtained by combining three rising methods in the field: SFG techniques that I have been spearheading, computer simulations and cryo-electron microscopy. We will study model water surfaces and, for the first time, realistic water aerosols interacting with INPs. These new strategies could lead to a paradigm shift in the entire field of ice nucleation and a search for similar processes in ice active fungi and pollen and abiotic ice nucleators – feldspar, silica and soot. The obtained information will provide critical input for climate models and revolutionary new freezing technologies for food preservation, cryomedicine and cloud seeding.

Keywords: sum frequency generation,ice nucleation,surface spectroscopy,biosurfaces
MethylRIDE: Charting DNA methylation reprogramming of Ice Age horses in the face of global climate change and extinction (MethylRIDE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2023-01-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

MethylRIDE: Charting DNA methylation reprogramming of Ice Age horses in the face of global climate change and extinction Adaptation is one of the most essential processes in biology, by which species become fit to their environment. Following Charles Darwin, adaptation appears as the result of natural selection acting upon heritable variation. However, recent epigenetic discoveries have established the capacity of non-genetic changes in the regulatory layers of gene expression to shape our traits, including our medical phenotype. As such, our realized phenotype can no longer be considered as the sole product of our genome, but more as the combinatory by-product of our genome and epigenomes. The outcome of natural selection, which favors phenotypes associated to a higher reproductive success in a given environment, might, thus, be at least partly influenced by epigenetic changes. Yet, the possible participation of epigenetic changes in the process of biological adaptation is generally overlooked. MethylRIDE will take advantage of the preservation of ancient DNA molecules in paleontological material to track the changes in DNA methylation profiles of Ice Age horses, as they faced changing climatic conditions and selection pressures and, ultimately, became extinct. The unique combination of novel experimental and computational techniques developed will help assess, for the first time, the role of epigenetics in long-term adaptive strategies of large vertebrates in response to rapid climate change, and more generally the role of epigenetic change as a significant evolutionary force.

Keywords: ancient dna,adaptation,horse evolution,extinction,climate change,epigenetics,environment
Fighting Cybercrime – Law Enforcement Practitioners’ Network (CYCLOPES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Coordination and support actions
Countries involved: Austria,Ireland,Spain,Germany,Germany,Malta,Cyprus,Finland,Belgium,Bulgaria,Croatia,Poland,Sweden,Poland,Latvia,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Pan-European networks of practitioners and other actors in the field of security (H2020-SU-SEC-2020, 2020)
Start date: 2021-05-01
End date: 2026-04-30
Duration (months): 60.0
Total project cost (EUR): 3499881.25
EU funding (EUR): 3499881.25
Participants: 21
Project status: SIGNED

A project to build and maintain an innovation-driven network of LEAs combating cybercrime - accelerating the EU’s ability to counteract growing pressures of cyber threats. Heeding advice from EUROPOL’s EC3 flagship report Internet Organised Crime Threat Assessment, CYCLOPES create synergies between LEAs from MS and connect industry and academia by stimulating and sustaining dialogue on pressing security matters threatening the stability of Europe and Citizen safety. Dedicated teams will scour markets, identifying solutions and research activities to highlight actions and innovative products to assist LEAs tackle the complexity of cybercrime. Besides technology, the project supports continued development of LEAs, working closely with practitioners to define current capacities and elicit capability gaps and requirements in crucial areas: procedures, training, legal and standardisation. Consequently, other objectives are: identification of priorities for standardisation; recommendations for innovation uptake and implementation; social, ethical and legal reports providing guidance and training suggestions for cybercrime investigators; dissemination of results through workshops, conferences, webinars, publications, policy papers and media. All outcomes will be suitably considered for exploitation - helping to propel the EU in the fight against cybercrime. Practitioners’ workshops are a driving force behind the project and cover three 3 domains: 1) cybercrime affecting people directly, 2) cybercrime affecting systems, 3) digital forensics. The project is to synchronise with other activities conducted by relevant parties EUROPOL, INTERPOL, CEPOL, ECTEG, ENISA; networks: ENLETS, ENFSI, I-LEAD, iLEAnet, EU-HYBNET, covering topics that go beyond efforts of these initiatives and preventing duplication. This also applies to projects where activities align with CYCLOPES (i-ProcureNet, Stairs4Security) and future projects funded by the EC, especially in the area of AI.

Keywords: law enforcement agencies,cybercrime,innovation uptake,standardisation
Elevating European digital innovator and venture ecosystems through integrated access to market expertise, co-investments and services in support of the EU digital policy priorities (EIC-EIT_Digital)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Coordination and support actions
Countries involved: Belgium,United Kingdom
Call: Ensuring greater synergies by testing new collaboration mechanisms between the EIT Innovation Communities and the Enhanced EIC Pilot in support of the the Green Deal and other Union policy priorities - Digital (H2020-IBA-EIC-DIGITAL-2020-2, 2020)
Start date: 2022-01-01
End date: 2023-06-30
Duration (months): 18.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 3
Project status: SIGNED

By building on the recommendations of the working group between EIC and EIT boards, the LoI between the 1st wave EIT KICs and EIC and the MoU between EIT and EIC, this proposed initiative aims at piloting mechanisms by which the most innovative businesses stemming from EIT Digital can be channeled to the Enhanced EIC Pilot, creating a pipeline of impactful innovations. In addition, the action will allow EIC-funded innovators to benefit from the support of the EIT Digital Accelerator and Innovation Factory. The collaboration will be along the following lines: 1. EIT Digital Accelerator: (i) EIC Accelerator scaleup systematic access to the EIT Digital Accelerator: base fee (50k) will be 100% discounted for selected EIC Accelerator-funded scaleups signing up during the pilot. This will guarantee scaleups having received EIC Accelerator funding, carefully selected by EIC based on excellence and growth potential (Seal of Excellence), to further grow with the support of EIT Digital and its network of corporates and investors. (ii) EIC investment in scaleups selected and coached by EIT Digital Accelerator would guarantee an intake of DeepTech scaleups with high-growth potential to the EIC and link them to a strong ecosystem of complementary investors. 2. EIT Digital Innovation Factory: (i) EIC grants and investments in ventures and activities of the EIT Digital Innovation Factory would further support innovative startups, maximize the outcome of EIT Digital and its strong partner ecosystem and ultimately build a strong portfolio of European centaurs and unicorns; (ii) Channel EIC Pathfinder innovators to EIT Digital Innovation Factory to create and validate strong business plans and build ventures to bring their solutions to the market. This will allow to build and grow European DeepTech ventures and help them succeed in the market. The ultimate goal of the collaboration will be to enhance European support to innovators in alignment with EC's priorities.

Keywords: co investment,systematic integration,eu competitiveness,investment facilitator,digital,innovation,start up,scale up
Development of functional, chemically defined coatings for 2D and 3D cell culture applications (TheraMatrix)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: SIGNED

Cell culture of primary and stem cells is basic for cell therapy approaches to treat degenerative, genetic, and immunological diseases. To enable mass production of cells utilized for these therapies, it is essential that the technologies used to manufacture, expand and differentiate cells are safe, robust, reliable and cost-effective. However, current stem cell culture technologies are often not sufficient for safe clinical application. This is mainly due to the quality of coatings mimicking biological conditions and surrounding of cells. Hence, motivation for this project is to produce a functional, chemically-defined coating for optimal stem cell culture. To realize this, a layer-by-layer technology for reproducible 2D biomatrix coatings will be established, accompanied by the development of a kinetic model and analytical methods for quality assessment. The achieved knowledge will be transferred to 3D cell culture and validation experiments with mesenchymal stromal cells will be conducted to confirm that the produced 2D and 3D biomatrices support cell growth. This project provides essential basic research to realize medical and regulatory needs with high exploitation potential. denovoMATRIX will implement this highly interdisciplinary and intersectoral project in an industrial as well as an academic context covering biological, chemical and physical aspects. The fellow, being chemist with expertise in colloidal and nanoscience, will receive a unique mix of specific research and transferable skills in the field of biomaterials and their application for-stem cell culture, underlined by a training plan to address the research objectives. Realization of the two-way knowledge transfer will result in strong benefits for both: new knowledge and a basis for a new class of products for the host, and diversification of professional competences and continuation of the fellow’s career perspective as a leading multidisciplinary researcher.

Keywords: peptides,glycosaminoglycans,layer by layer,noncovalent coating,microcarrier,cell therapy application,model development,3d culture,bioreactor,cell culture,stem cells,chemically defined
MAKING an EASY and VALUABLE way for INNOVATION WITH PEER LEARNING (MEVINO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain,Germany,Bulgaria,Türkiye
Call: peer learning of innovation agencies (H2020-INNOSUP-2014-5, 2014)
Start date: 2016-02-01
End date: 2017-04-30
Duration (months): 15.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 4
Project status: CLOSED

The common challenge of the MEVINO project is the increase of regional SMEs’ innovation activities through a more effective delivery of professional entrepreneurial support for potential innovative entrepreneurs and innovative start-ups. Fostering innovative entrepreneurship with public funding and public guidance for entrepreneurs contributes to a thriving economy and to the reduction of unemployment rate. All four consortium partners are responsible for designing and delivering entrepreneurial support in their regions. There are highly experienced and less experienced partners in this project proposal. By following the twinning advanced methodology all entrepreneurial activities of the partner organisations and their experiences will be shared in a structured way following the 4+1 Phase Model which is successfully applied by the MEVINO partner KOMPASS since years. The Model and the guidebook provide the theoretical and scientific foundation in terms of knowledge, competency and skills, needed by a Business Advisor in start-up consultation. Peer reviews of the current entrepreneurial support services provided by the partner organisations and the peer learning process with elaboration of the joint Design Options Paper with individual improvement measures for the 4 partner organisations will follow the 4+1 Phase Model. The project will gather the activities, approaches, Good Practices depending on partners’ post experiences in different applications of their entrepreneur support activities in the MEVINO GP pool where all partners can find something to import and implement in their own region. Considerable impact of this project will be generated through improvement of the entrepreneurship support model in partner organisations. The elaborated improvement measures as part of the Design option paper will be implemented after the end of the MEVINO project and MEVINO partners will stay in contact during implementation for exchanging their experiences in implementation.

Keywords: promote entrepreneurship,entrepreneur training,entrepreneurial support