Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
EVALUATION OF LIPID LEVELS PRIOR AND DURING GESTATION AND ASSOCIATION WITH ADVERSE PREGNANCY OUTCOMES AND SUBSEQUENT DEVELOPMENT OF TRUE DYSLIPIDEMIA. POPULATION BASED STUDY. (PREDICT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-04-01
End date: 2015-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Background: The metabolic syndrome is characterized by a group of metabolic risk factors such as obesity (mainly abdominal obesity), atherogenic dyslipidemia (high triglycerides, low HDL cholesterol), elevated blood pressure and dysglycemia. Several components of the metabolic syndrome (glucose intolerance and elevated blood pressure) are known risk factors for development of pregnancy complications. The objective of the proposed study is to characterize the metabolic syndrome and especially disturbance of lipid homeostasis over the reproductive cycle of women life starting from preconception assessment, through gestational period and during three years following birth. Study cohort The study population of 600 women undergoing pre-pregnancy routine assessment will be enrolled. At the baseline detailed medical history assessment, physical examination and blood tests will be performed. This cohort will undergo the similar assessment at weeks 12, 24 and at the delivery.This cohort will be assessed again annually for 3 years following the delivery (medical history; physical examination and blood tests). Hypotheses: 1) Elevated triglycerides levels (≥150mg/dL) and/or low levels of high density lipoprotein (<50mg/dL) assessed prior to conception are associated with preeclampsia/ eclampsia, and/or gestational diabetes mellitus. 2) Elevated triglycerides levels (>75 percentile for the appropriate gestational age) and/or low levels of high density lipoprotein (<25 percentile) assessed during the gestation are associated with the adverse pregnancy outcomes. 3) Women with elevated triglycerides levels and low levels of high density lipoprotein during pregnancy have higher rates of metabolic syndrome at 3 years after the delivery. Importance: Our study will help to identify additional risk factor for adverse pregnancy outcomes and identify a risk group for development of insulin resistance associated pathologies such as dyslipidemia and metabolic syndrome.

Keywords: health sciences,reproductive health,metabolic syndrome,lipids,preeclampsia,gestational diabetes mellitus
Reliable and Efficient Combustion of Oxygen/Coal/Recycled Flue Gas Mixtures (RELCOM)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Clean coal technologies
Action type: Collaborative project
Countries involved: United Kingdom,Finland,United Kingdom,Germany,France,United Kingdom,Poland,Germany,Belgium,United Kingdom,Italy,Spain
Call:  (FP7-ENERGY-2010-2, 2010)
Start date: 2011-12-01
End date: 2015-11-30
Duration (months): 48.0
Total project cost (EUR): 9865871.95
EU funding (EUR): 6468900.0
Participants: 14
Project status: CLOSED

Most coal-fired utility boilers are fired with pulverised coal and the use of this technology for power generation far outweighs that of alternatives. The consortium have identified key issues that need to be addressed to pave the way for full-scale deployment of oxy-coal firing. As most previous work has been undertaken at pilot-scale so that, in addition to medium scale demonstration activities, there is also a need for more fundamental underpinning studies to provide improved understanding of oxy-fuel firing technology before it can be taken reliably even to the large scale demonstration stage. The overall aim is to undertake a systematic and focused series of applied research, development and demonstration activities involving both experimental studies and combustion modelling work to resolve existing technical uncertainties and barriers which inhibit commercial deployment of the technology. Attention will be paid to the generation of design rules and methods which can be employed for scaling up results from pilot and laboratory studies to the full-scale. The data obtained in the experimental tests and from the developed modelling tools will be integrated to produce detailed designs for both a retrofit oxy/coal/RFG system for an existing boiler as well as a novel design for “new build” plant. The programme of work will therefore enable full-scale early demonstration plant to be designed and specified with greater confidence as well as providing improved assessment of the commercial risks and opportunities.

Keywords: oxygen,combustion,efficiency,reliability
GREENHOUSE GAS RECOVERY FROM COAL MINES AND UNMINEABLE COALBEDS AND CONVERSION TO ENERGY (GHG2E)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Cross-cutting actions between activities Energy-5 and Energy-6
Action type: Collaborative project
Countries involved: United Kingdom,China,India,United Kingdom,Slovenia,Slovakia
Call:  (FP7-ENERGY-2010-2, 2010)
Start date: 2011-10-01
End date: 2015-03-31
Duration (months): 42.0
Total project cost (EUR): 2447811.2
EU funding (EUR): 1635775.44
Participants: 12
Project status: CLOSED

Coal mining and utilisation results in release of significant amounts methane and represent an important threat to the fight against climate change. Coal Mine Methane drainage processes can be set up to recover methane from the emissions during coal production. Methane can also be extracted from virgin coal seams trough primary and enhanced coalbed methane recovery. The main objective of the proposed research project is to contribute to the global GHG emissions reduction objective by addressing the key challenges facing the industry and emerging economies which also are major coal mining counties worlwide. This objective canbe expanded upon as follows: - to achieve significant improvements in methane drainage efficiency and purity in coal mines in the emerging economies of China and India, where methane drainage is employed with relatively low yields of gas and purity. - to develop a novel and effective gas drainage techniques for the ultra-thick seam and gassy mining operations in Europe - to investigate the benefits of implementing horizontal wells for coalbed methane (CBM) and coupling horizontal wells with the injection of CO2 and/or CO2 enriched flue gas to enhance methane recovery and CO2 storage - to disseminate the know-how developed across the coal sector internationally

Keywords: coal mine methane,coalbed methane,enhanced coalbed methane,methane drainage efficiency,methane purity,energy
Large scale Smart Grids demonstration of real time market-based integration of DER and DR (ECOGRID EU)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Smart energy networks
Action type: Collaborative project
Countries involved: Norway,Denmark,Denmark,Belgium,Spain,Austria,Netherlands,Estonia,Portugal,Netherlands,Denmark,Germany,Belgium,Denmark
Call:  (FP7-ENERGY-2010-2, 2010)
Start date: 2011-03-01
End date: 2015-09-30
Duration (months): 55.0
Total project cost (EUR): 20523497.7
EU funding (EUR): 12649939.5
Participants: 17
Project status: CLOSED

The key objective of the EcoGrid EU project is to demonstrate efficient operation of a distribution power system with high penetration of many and variable renewable energy resources. The demonstration will take place on the Danish island Bornholm with more than 50 % of electricity consumption from renewable energy production. A real-time market concept will be developed to give small end-users of electricity and distributed renewable energy sources new options (and potential economic benefits) for offering TSOs additional balancing and ancillary services. Strong industrial participation and innovative experiences from related European and US Smart Grids RD&D project will contribute to the development and implementation of robust ICT platforms and information architectures. This is the key to allow all distributed energy resources to participate actively in the real-time power market. Of a total of 28 000 customers on Bornholm, at least 2600 residential consumers will participate with flexible demand response to real-time price signals. The participants will be equipped with residential demand response devices/appliances using gateways and “smart” controllers. Installation of the smart solutions will allow real-time prices to be presented to consumers and allow users to pre-program their automatic demand-response preferences, e.g. through different types of electricity price contracts. “Automation” and customer choice is one of the key elements in the EcoGrid EU concept. To make the EcoGrid EU solutions more widely applicable, the market concept will be designed for existing power exchange(s) and power regulation market(s). Because of the test site location on Bornholm, the real-time market concept will first be operational in the Nordic power market system. EcoGrid EU replication activities will ensure that the concept (or part of the solutions) can be adjusted and prepared for implementation in other power systems and regulatory conditions across Europe.

Keywords: smart grids,market based,end user involvement,ict technology,demonstration
Multipurpose Applications by Thermodynamic Solar (MATS)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable electricity generation
Action type: Collaborative project
Countries involved: Italy,Egypt,Germany,United Kingdom,France
Call:  (FP7-ENERGY-2010-2, 2010)
Start date: 2011-07-19
End date: 2018-10-18
Duration (months): 87.0
Total project cost (EUR): 21989664.01
EU funding (EUR): 12515552.0
Participants: 11
Project status: CLOSED

The proposed MATS Project aims at promoting the exploitation of concentrated solar energy through small and middle scale facilities, suitable to fulfil local requirements of power and heat, and easily to back-up with the renewable fuels locally already available or that can be expressly produced. The implementation of the project will allow to test the CSP (Concentrating Solar Power) technology in a location very advantageous with regard to the solar radiation rate as an example for the diffusion of this technology in other Mediterranean Countrie. Besides, it will represent the start-up for a development of specialized local industries. More in detail, the MATS project is focused on the innovative CSP technology developed by ENEA as an improvement of its Solar Thermodynamic technology based on molten salts as heat transfer fluid. This technology, referred as TREBIOS, allows combined heat and power production from solar source integrated with renewable fuels, such as biomass, biogas, industrial residues etc. by means of standardized units that provide high performances and limited cost. The objective of the proposal is the full scale demonstration of TREBIOS technology through the industrial development, the realization and the experimental operation of a multipurpose facility to be installed in Egypt. The thermal energy produced by this plant will be used as energy source in a desalination unit included in the installation, as well as for district heating and cooling. The use of suitable heat storage systems enhance mismatch of power production from the instantaneous solar radiation availability. These features enable electrical energy production “on demand” and the optimized utilization of captured solar heat by additional loads like desalination units. The integration with a back up fuel like biomass makes the system flexible and enables continuous power production

Keywords: photovoltaic,concentrating solar power,solar termodynamic,reflecting surfaces,thermal energy storage system,molten salt
Identification of the process by which patients recall and UPDATE their subjective RISK assessments for various diseases to incorporate objective genetic risk information (RISK-UPDATE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-11-01
End date: 2014-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Project RISK-UPDATE will support the reintegration of Dr Talya Miron-Shatz, after four years spent as post-doctoral research collaborator with Nobel Laureate Prof. Daniel Kahneman at Princeton University, in the USA. Dr Miron-Shatz’s new host institution is Ono Academic College, Israel, which has agreed to set up a new research centre to facilitate her proposed studies, which she will direct. In this project, the Researcher will produce a model of risk information processing in order to improve patients' ability to integrate risk information relating to genetic predisposition to diseases and conditions. The research will follow the path of risk estimates told to patients by a genetic counsellor, for two genetic illnesses: Alzheimer’s Disease and breast cancer. Patient recall of this estimate and perception of the risk will be analysed. Few studies have traced this process, and initial research indicates that information conveyed by geneticists and counsellors is often lost or distorted, and when this happens, patients retain assessments of greater risk. This may cause individuals to undergo unnecessary procedures to deal with risks which are perceived as greater than they really are. Two trends coincide to make this research timely and important: 1. genetic testing is becoming more widespread and cheaper; 2. increasingly, patients participate in decisions affecting their health, which, in the past, were the responsibility of doctors alone. The core aim of this research will be to develop a model to enable prediction of when this phenomena will arise, and to quantify the extent of the difference between patients’ and health professionals’ perceptions of the genetic risk. Factor analysis, and quantitative content analysis methods will be applied to supplement the investigation. This model can then be used by geneticists and genetic counsellors to facilitate accurate recall and adoption of risk information by patients for a range of diseases and conditions.

Keywords: health sciences,social sciences
Development of nano-spheres and quantum dots for electrochemiluminescent (ECL) biomedical diagnostic sensor technologies (ECL NANO-MATERIALS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-10-01
End date: 2014-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This programme addresses how single molecules such as quantum dots or metal centres within nano-structured polyelectrolytes can be used to create efficient electrochemiluminescent (ECL) sensors multi-analyte detection, specifically for biomedical sensors with ultra-high sensitivities and selectivity’s. The unique capabilities of these novel nano-materials will arise from the coupling of photonic, chemical, optical and fouling resistant properties of each component to create a sensitive and selective detection system while allowing for applications in point of care devices. A combination of spectroscopic and electrochemical techniques will be utilised to elucidate the electron and/or energy transfer mechanisms, which will allow optimisation of device performance to be performed. The spectroscopic and electrochemical techniques highlight the redox reactions influencing the ECL production. Tailoring of surface properties and modification of polyelectrolytes will involve the use of several analytical techniques, including atomic force microscopy and electrochemical quartz crystal microbalance analysis. These studies focus on the binding of the polyelectrolyte, which will impart desirable surface chemistries at the material-solution interface to optimise the fouling resistant properties while retaining the sensitivity and selectivity of its ECL production for applications in imaging technologies. These materials will feed into product development which will incorporate sensor design, novel detection platforms and easy to use devices. The development of novel 2nd and 3rd generation materials will focus on the detection of cardiac Troponin I (TNI). The properties of these materials will uniquely enable the development of advanced diagnostic devices based on the luminescent detection of TNI at sufficiently low concentrations so as to change clinical practice.

Keywords: electrochemistry,photochemistry,spectrochemistry,electrochemiluminescence,quantum dots,polyelectrolytes,biomedical sensors,nanomaterials
Matrix metalloproteinase degradomics at the epidermal-dermal interface (SKINTERMINOMICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2010-11-01
End date: 2013-10-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Matrix metalloproteinases (MMPs) regulate processes within the dermal and the epidermal compartments and particularly at the epidermal – dermal interface. This is of crucial importance for wound repair and also for the pathogenesis of skin cancer. One member of the MMP family - MMP-10 - gained particular interest, since it is specifically expressed at the leading edge of hyperproliferative keratinocytes in wounds and in skin tumors. The key to unravel the mechanism of MMP-10 action is the system-wide identification of its substrates under physiological and pathological conditions. To do so, we will use Terminal Amine Isotopic Labeling of Substrates (TAILS), a novel iTRAQ-based quantitative proteomic technique for the multiplex system-wide discovery of protease substrates and their cleavage sites. We will apply TAILS to identify novel bioactive MMP-10 substrates in vitro using primary keratinocytes from wild-type and MMP-10 knockout mice and from fibroblasts grown in mono- or co-culture. Thereby, we will employ 4plex-iTRAQ-TAILS to define both MMP-10 substrates and their cell type-specific origin in a single experiment. In addition, we will use TAILS to examine N-terminome changes during chemically-induced skin carcinogenesis in wild-type and MMP-10 deficient animals. This approach will allow to identify MMP-10 in vivo substrates but also to monitor the generation of neo-N-termini in wild-type controls at each important step of skin carcinogenesis in an unbiased manner. Cleavage site specificities will relate these to potential protease pools that will be defined from concomitant expression analysis using a dedicated protease microarray, the CLIP-CHIP(TM). Proteases, in particular MMPs, which are highly expressed during skin carcinogenesis, will be further analyzed for their substrates by iTRAQ-TAILS. These experiments will provide new insight into the role of proteases, including matrix metalloproteinases, in non-melanoma skin cancer development and progression.

Keywords: biology,systems biology,proteomics,skin cancer,proteases,degradomics
Origin and evolution of host-association and pathogenicity in the Rickettsiales (RICKOCHET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-01-01
End date: 2013-12-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Despite that many human diseases are caused by bacterial pathogens, not much is known about how these pathogenic bacteria emerge. The alpha-proteobacterial order Rickettsiales comprises intracellular bacterial pathogens, including the causative agent of epidemic typhus, Rickettsia prowazekii. The overall aim of the current project is to gain insight in the evolutionary transition from free-living bacterium to (human) pathogen, using the Rickettsiales as a model system. To do so, deeply branching Rickettsiales lineages will be isolated from environmental samples and from amoeba that contain Ricketsiales-like endosymbionts. Free-living Rickettsiales species will be isolated from the Sargasso Sea using a single-cell genomics approach. In parallel, protist-associated Rickettsiales species will be isolated from amoeba. Subsequently, an attempt will be made to determine the complete genome sequence of the obtained free-living and ciliate-associated Rickettsiales species. By comparing the obtained genomic data with that of their pathogenic relatives, principle differences will be revealed that should give insight in the evolutionary transition from free-living bacterium to human pathogen. The proposed study aims at enumerating a number of pathogenicity genes that could represent excellent targets for vaccine development for treatment of infections caused by pathogenic Rickettsiales species.

Keywords: evolutionary biology,microbiology,genomics,environmental genomics,computational biology