Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Multivariate selection and human-induced environmental stress: adaptive genetic and plastic responses in the yellow dung fly (SUPAFLY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-10-01
End date: 2012-09-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

One of the main tasks of evolutionary ecology is to characterize and explain the causes of phenotypic variation. Quantifying the relative contribution of genetic and ecological processes and their interaction is also important to predict future response of populations to human-induced environmental changes. The overall goal of the proposed research is to determine whether and to what extent two simultaneously induced new selection pressures are likely to slow or accelerate evolution relative to the case where only one selection pressure is present. In order to achieve this goal, I plan to collect extensive evidence on the nature of multivariate selection, genetic architecture, phenotypic plasticity, and evolutionary potential of Fennoscandian populations of the yellow dung fly (Scathophaga stercoraria). More specifically, the aims are 1.To compare the intensity and form of natural and sexual selection on fitness components across populations inhabiting six different locations in Fennoscandia 2.To relate the form and intensity of selection in the field with the genetic architecture of traits under selection using a laboratory quantitative genetic experiment 3.To examine changes in the potential for evolutionary responses to selection as a function of the number and intensity of stresses using a genotype by environment interaction experiment 4.To develop, parameterize and analyze a model of population and evolutionary dynamics under different predicted future environmental scenarios focusing on realistic description of ecological and genetic processes describing individual growth, survival and fitness

Keywords: climate change,quantitative genetics,response to selection,environmental stress,genotype by environment interaction,g-matrix,dung fauna,ecosystem services,population dynamics
CO-design and Power Management in PLatform-based Design Space EXploration (COMPLEX)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Components, systems, engineering
Action type: Collaborative project
Countries involved: Germany,Italy,Netherlands,France,Spain,France,Spain,Italy,Belgium,France,China
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2009-12-01
End date: 2013-03-31
Duration (months): 40.0
Total project cost (EUR): 7049256.0
EU funding (EUR): 4708736.0
Participants: 15
Project status: CLOSED

The main objective of the COMPLEX project is to increase the competitiveness of the European semiconductor, system integrator and EDA industry by addressing the problem of platform-based design space exploration under consideration of power and performance constraints early in the design process. High performance usually causes high power consumption. A main challenge in today’s embedded system design is to find the perfect balance between performance and power. This balance can not be found efficiently and at high quality, because until now no generic framework for accurately and jointly estimating performance and power consumption starting at the algorithmic level is available. This can only be achieved in cooperation on a European level, taking into account European platform providers, system developers/integrators, EDA companies, Universities and research institutes from both, the HW and the embedded SW world. The COMPLEX project will enable the European semiconductor and electronic system industry to achieve a break through in product quality through substantially improved performance and power efficiency. This quantum leap will be achieved by a new design environment for platform-based design-space exploration offering developers of next-generation mobile and embedded systems a highly efficient and productive design methodology and tool chain allowing them to iteratively explore and refine their applications to meet market requirements. The design technology in particular enables the fast simulation and assessment of the platform at Electronic System Level (ESL) with up to cycle accuracy at the earliest instant in the design process. Several new modelling, exploration and simulation concepts will be developed and combined with well established ESL synthesis, cross-compilation, analysis and simulation tools into a seamless holistic design flow enabling performance &amp; power aware virtual prototyping from a combined hardware-software perspective.

Keywords: co-design,design space exploration,platform-based design,power management,virtual platform
Multiple ergodic averages and combinatorics (MEAC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-10-01
End date: 2013-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The proposed research lies in the area of ergodic theory and has several potential implications in combinatorics. In ergodic theory, the investigator, building on his previous work, plans to carry out an in depth analysis of the limiting behavior of multiple ergodic averages along various integer sequences, for example Hardy sequences, random sequence, and sequences related to the prime numbers. The tools to be used include recent advances in the theory of characteristic factors and equidistribution results on nilmanifolds. The combinatorial implications are related to exhibiting patterns that can be found within every set of integers with positive density, thus obtaining several far reaching extensions of the celebrated theorem of Szemeredi on arithmetic progressions. Such results serve as a first step in exhibiting the same patterns within the set of prime numbers.

Keywords: mathematical analysis,discrete mathematics
Sympathetic Cooling of Molecular Ions in Microstructured Ion Traps on Chips (MOLI MICROTRAP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-10-01
End date: 2011-09-30
Duration (months): 24.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project aims at developing a flexible, compact, microstructured trapping device for conducting various precision experiments with single cold (T≈mK) molecular ions. Several control tools will be established in the view of realizing a “cold chemistry lab on a chip”. For this purpose the following steps are required: (1) designing and constructing a novel type of ion trap, a microtrap, tailored towards the sympathetic cooling of molecular ions, with an open geometry and increased controllability of the trapping potentials; (2) perfecting routine experimental techniques: ion loading, trapping, laser- and sympathetic cooling; (3) establishing protocols for state preparation and mass spectrometry of the sympathetically-cooled ions in the trap; and, finally, (4) demonstrating the potential of the system through the implementation of optical preparation and interrogation protocols of cold molecular ions and cold chemistry experiments.

Keywords: physical sciences,atomic physics,molecular physics,spectroscopy,ion traps
Diversity Generating Retroelements – Understanding a New Class of Mobile RNAs (RETROELEMENTS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-10-01
End date: 2013-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Retroelements are genetic elements that use reverse transcriptase to insert DNA copies of their RNA into new locations in the host genome. They are found in all realms of life and are one of the major agents shaping genomes. A newly discovered class of viral and bacterial retroelements, the diversity-generating retroelements (DGRs), have the unusual ability to repeatedly target and mutagenize a defined region of the host genome. This process is conceptually similar to the antibody diversification process of the immune system, but has developed independently and thus employs an entirely different mechanism. The proposed project seeks to elucidate several aspects of DGR function in order to deepen our understanding of this novel mutagenic mechanism and evaluate its implications and applications in such diverse fields as biotechnology, medicine, evolution and immunology. The first major aim will be the development of a fluorescence-based in vivo assay system for DGR activity. This will speed up the experimental read-out drastically and allow for systematic screening to identify crucial components of the mutagenic mechanism. In parallel, the molecular components of DGR elements will be characterised in the second research aim. The reverse transcriptase protein and the RNA template will be investigated using biochemical, biophysical and structural methods. Many components of this proposal draw heavily on my postdoctoral experience, while other parts require co-operation with groups at the host university and European research institutes. Moreover, through teaching at university level, I will be able to train young researchers and expose them to cutting-edge research. Taken together, the proposed project thus leads to knowledge transfer into the European Union, long-term re-integration of a European researcher, and introduction of an exciting new research field that is currently underrepresented in Europe.

Keywords: retroelements,genetics,biochemistry,microbiology,genome diversification,genetic selection,targeted mutagenesis,evolution,rna,reverse transcriptase,target primed reverse transcription
Molecular Basis for Unwanted Side-Effects During Interferon Therapy (MBFUSEDIT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2011-09-01
End date: 2014-08-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

First-line immunomodulatory treatments such as beta-interferons (IFN-alpha/beta) for multiple sclerosis are available to reduce the rate of relapses and disease activity. However, in addition to its therapeutic effect, systemic IFN-beta treatment causes severe neuropsychiatric complications in humans, including depression and cognitive impairments. These side effects are common and can limit the treatment utility. Our long-term goal is to elucidate the molecular mechanisms of these unwanted side effects in order to improve IFN-beta therapy. The specific hypothesis is that systemically applied IFN-beta exerts adverse side effects by activation of the respective receptor of type I interferons (IFNAR) in the central nervous system (CNS). To identify the actual cell type targeted by IFN-beta in the brain, we have generated brain-specific and glia-specific IFNAR-deficient mice. With the help of these animals we will determine which interferon-stimulated genes will be activated in the brain upon systemic IFN-beta application. We will further assess the contribution of central IFNARs to IFN-beta mediated “sickness” behavior, which includes depressive-like behavior and cognitive impairment and we will correlate these behaviors to changes in hippocampal synaptic plasticity. Together, these experiments will be crucial to identify neurobiological mechanisms responsible for the unfavorable side effects accompanying IFN-beta therapy and to evaluate interventions to ameliorate them.

Keywords: translational research,animal model,interferon treatment,side-effects
Probing the relativistic jet composition in high energy active galactic nuclei (HE-COSMIC-SOURCES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2009-11-01
End date: 2013-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The proposed project aims at probing the relativistic particle content of the most numerous, persistent population of high energy cosmic sources in the Universe: jets of active galactic nuclei (AGN). This undertaking is leveraged by today&apos;s synergy of high performance ground- and space-based photon detecting instruments as well as key advances in astroparticle physics experiments, yielding dense high quality data over a broad energy range from a large collection of AGN. Such powerful objects are among the prime candidate sources of the enigmatic ultrahigh energy cosmic rays, however, conclusive evidence is still missing. The development of diagnostic tools that probe the composition of the material in AGN jets, that go beyond the so far used broadband modeling methodology, is key to this project, and allows a systematic search for observational features of hadronic interactions from high energy cosmic jet sources. Meaningful constraints on their relativistic particle content will have far-reaching implications for the physics of cosmic rays, particle acceleration to energies beyond reach for any terrestrial laboratory, and our physical understanding of jet formation, collimation and mass loading. Furthermore, significant impact for searches of extragalactic neutrino sources is expected. This project will promote the professional reintegration of the proposer, who has a strong background in broadband modeling including hadronic processes, into the European astroparticle physics community, will complement the activities of the center of experimental astroparticle physics at Innsbruck University, and strengthen the scientific return of neutrino astrophysics experiments with its strong presence in Europe.

Keywords: physical sciences,astroparticle physics,extragalactic sources,ultrahigh energy cosmic rays,cosmic gamma rays,cosmic neutrinos,non-thermal radiation processes,broadband modeling
Energy consumption prediction with building usage measurements for software-based decision support (ENPROVE)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: ICT for mobility, environmental sustainability and energy efficiency
Action type: Collaborative project
Countries involved: Portugal,Ireland,Germany,France,Spain,Poland,France,Netherlands,Germany
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-02-01
End date: 2013-04-30
Duration (months): 39.0
Total project cost (EUR): 3683629.0
EU funding (EUR): 2499918.0
Participants: 9
Project status: CLOSED

The objective of EnPROVE is to develop a software model for predicting the energy consumption of a specific building, with different scenarios implementing energy-efficient technologies and control solutions, based on actual measured performance and usage data of the building itself. The key hypothesis of EnPROVE is that it is possible, from adequate gathering and assessing data on how a structure performs and is being used from an energy viewpoint, to build highly accurate and specific energy consumption models relevant for prediction of alternative scenarios. The EnPROVE software tools will assess the energy-efficiency impact of alternative technologies for which available investment resources can be directed and, thus, support the decision maker finding the optimised set of energy-efficient solutions to be implemented. These results will be tailored to the actual building itself, through automated measurements of the building usage and energy efficiency. Technological solutions will include energy-reducing, -generating, and –storing options, and with user-defined criteria on resources and restrictions, will identify through new prediction algorithms when the return on investment will be realized. By solving these problems, EnPROVE will be able to develop crucial new tools, interoperable with existing CAD or Facility Management tools, to model the energy consumption from monitored data, predict the performance of alternative scenarios and support the decision maker in finding the optimal point for the investment. Compared to current available energy auditing services and prediction tools, it is foreseen that EnPROVE will increase the cost-effectiveness of renovation investments by 15 to 30%. These services will open new business opportunities for both construction companies that work on building renovation, as well as building management companies on long-term contracts. The application of the tools will be validated in two real buildings.

Keywords: energy efficiency,consumption model,decision support system,wireless sensor network
Sleep Loss in Adolescence: Effects on Cognition, Mood, and Behavior (SLEEP LOSS IN TEENS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-08-01
End date: 2015-01-29
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

One of the most significant and dangerous social and public health problem facing adolescents today is sleep loss. Chronic partial sleep deprivation has achieved epidemic proportions in youth, with approximately 80% of teens not getting the needed amount of nightly sleep. Despite the alarmingly high rates of sleep deprivation in teens, its impact on daytime function, including sleepiness, mood, and cognition remain poorly understood. To address this knowledge gap, we intend to examine sleep, neuropsychological (NP) performance, and mood in the natural environment in 40 healthy adolescents (ages 16-18; 50% female). Each teen will undergo 2 different sleep conditions: 1) an “extended” sleep period consisting of 5 consecutive days of 10-10.5 hrs in bed/night; and 2) a “typical” sleep period consisting of 5 consecutive days of 7.5-8.0 hrs in bed/night (the common sleep duration for this age group). The former will provide sleep satiation or optimal biological sleep need (for this age group), while the latter will result in an insufficient amount of sleep. Each teen will be randomly assigned to one of the sleep conditions, followed by a 2-week “recovery” period, and then the other sleep condition. Sleep testing will include continuous actigraphic monitoring throughout each sleep protocol and one overnight polysomnography recording at the beginning of the study to rule out any sleep disorders. Following the last night of each sleep condition, teens will undergo a battery of standardized NP tests to examine performance in cognitive areas previously found to be related sleep deprivation, including verbal learning, memory, processing speed and attention, inhibition, working memory, and executive function. Findings will increase our knowledge of the correlates of sleep loss in teens and will be useful public policy and education data. Furthermore, it will allow the researcher the opportunity to continue her line of research and reintegrate into the host country.

Keywords: adolescence,sleep loss,cognition,mood,actigraphy,polysomnography
The Community Network Game (CNG)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Pervasive and Trustworthy network and service infrastructures
Action type: Collaborative project
Countries involved: Greece,France,United Kingdom,Sweden,United Kingdom,Israel
Call:  (FP7-ICT-2009-4, 2009)
Start date: 2010-02-01
End date: 2012-11-30
Duration (months): 34.0
Total project cost (EUR): 3808105.0
EU funding (EUR): 2903352.0
Participants: 8
Project status: CLOSED

Gamers on an MMOG may become an active community having common interests, adventures and sharing common objectives. The CNG project intends to enhance the activities between the online gamers and develop the tools for generation, distribution and insertion of User Generated Content (UGC) into existing MMOGs. The CNG project intends to research and develop (1) in-game community activities using in-game graphical insertion technology and (2) a P2P architecture for the distribution of UGC. (1) The In-Game Graphics Insertion Technology (IGIT) is an innovative technology of replacing or inserting content to the game in real time without the need to change the game’s code in the client or server. IGIT can be used to change existing game objects and to insert additional objects on demand. For example, Player face can be customized, billboards can be added, and area on the screen can be allocated for user information. The technology does not require any change to the game code. By implementing the technology on multiple games it is possible to create a community that is not limited to a specific game or publisher and can be extended to share any information between the users in real time. (2) Current MMOG architectures rely on the idea that central servers are responsible for hosting all the items needed and shared during a game. The New Community Project proposes to integrate a P2P overlay into an existing MMOG architecture to stream user-generated content (3D animated objects, video) from one user to other user or from one user to many users. This traffic represents a real challenge to the network being already occupied by the MMOG client server data. The project intends to research and develop new techniques for P2P 3D/Video streaming that are “friendly” to the MMOG client server communication.

Keywords: mmog,games,p2p,ugc,graphics insertion