Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
European Advanced Superconductivity Innovation and Training (EASITrain)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria,Germany,Germany,Germany,Italy,Austria,Germany,Germany,Germany,Italy,Italy,Switzerland,Switzerland,France,France,France,United States,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2017-10-01
End date: 2021-09-30
Duration (months): 48.0
Total project cost (EUR): 3841922.16
EU funding (EUR): 3841922.16
Participants: 24
Project status: CLOSED

The two greatest obstacles to a wide spread adoption of superconductivity remain the limited understanding of its fundamental principles and the yet insufficient capability for large-scale, cost-effective deployment of the technology. Science rather than serendipity is the key to unlock the potentials of this alluring natural phenomenon. The proposed ITN integrates sound research projects aimed at learning to predict the behaviour of superconducting materials, at introducing innovative manufacturing techniques, at developing efficient cryogenic refrigeration techniques as key enablers for future applications and establishing these technologies as the new state of the art. The ambitious goals of this consortium are (1) making advanced superconductors fitter for the market, (2) assessing their innovation capacities and (3) equipping a new generation of researchers with the unique skills required to convert knowledge into products: Efficient grid power management, 21st century medical imaging, leaps in effectiveness of wind power generators, efficient electric propulsion systems and sustainable refrigeration for industry give an impression of the potential societal benefits that superconductor-based technologies can catalyze. This initiative under European leadership federates leading universities, research centres and industries, embracing a variety of science sectors, such as physics and mathematics, material sciences, process and mechanical engineering, refrigeration, cryogenics and innovation management. The intriguing blend of science and engineering, compounded by visionary application opportunities in companies, creates a fertile environment for innovative training of early-stage researchers. Significant training lead-times call for a dedicated action. This ITN will provide its fellows with a sound knowledge in the relevant fields along with business competences and prepare them for a broad spectrum of career opportunities in research and industry.

Keywords: superconducting wires,superconducting thin films,superconducting magnets,cryogenics,turbo compressors,high velocity forming,radio frequency cavities,technological competence leveraging
Lakhesys: building the machine to make the medicines of tomorrow (Lakhesys)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-03-01
End date: 2023-02-28
Duration (months): 48.0
Total project cost (EUR): 2817143.75
EU funding (EUR): 1972000.63
Participants: 1
Project status: CLOSED

Chimeric Antigen Receptor T-cell therapies (‘CAR-T’) are ushering in an incredibly exciting era of using a patient’s own cells to cure their cancer. The prospect of using a patient’s own cells to cure their disease is theoretically limitless. However, with all of this excitement comes a shadow. The cost of these life-saving treatments is currently so prohibitive that it threatens to put extreme cost-pressure on healthcare providers globally in the years ahead. Astraveus has developed a highly innovative microfluidic chip that can fundamentally change the CAR-T industry. This chip answers the need to lower production cost (by ~70%), improve treatment quality and allow upscaling of treatment volumes to the required levels. Astraveus has also developed equipment to optimize the use of these microfluidic chips. They have incorporated these technologies into a working prototype of an instrument called ‘Lakhesys’. This instrument allows for automated, standalone, end-to-end production of a CAR-T therapy. The design, fabrication and validation of the microfluidic innovation is a real breakthrough in the ability to cheaply and accurately produce these treatments. The further step of incorporating these chips into a prototype system demonstrates the huge potential for automating CAR-T production. This phase-2 project will upgrade the supporting modules to turn this working prototype into a launch-ready product. It will also support the validation and industrialisation steps to bring this innovation to market. The industry is dominated by players in the USA and China (72% of CAR-T institutions are based in these two countries). Astraveus has invented something incredibly unique and a complete step-change versus anything seen on the market. As such, we present an opportunity to support the creation of a homegrown EU business that can challenge the status quo and, more importantly, put these life-saving therapies in the hands of all patients who need them.

Keywords: car t,chimeric antigen receptor,microfluidics
Schools of Citizenship: Parent Councils at Public Schools in Italy, Spain, and France (PARENT_CITIZENS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: SIGNED

In the wake of economic, climate, and violent crises throughout the Mediterranean region, Europe has recorded more asylum seekers and immigrants during the past decade than ever before. As these new populations seek to integrate into European society, the following questions arise: are there sufficient institutional sites and resources to civically incorporate these incoming individuals and families? More importantly, what are the appropriate and practically effective institutions to build shared values of tolerance, respect, and citizenship? The purpose of this interdisciplinary project is to investigate the public institution most directly responsible for civic education, public schools, in three of the highest immigrant destination countries in Europe: Italy, Spain, and France. Yet while most European wide civic education initiatives focus on school children, the focus of this study is parent participation on parent councils (assemblee genitori, asociación de padres, conseil des parents d'élèves) at schools. In many nation states throughout Europe, parents have the right and expectation to participate at schools through legally codified parent councils, yet they remain little understood as a vehicle for productive civic integration. This absence in the scholarly literature and European institutional initiatives is surprising given the established finding that schools are the primary public institution where immigrants interface with others and participate civically. In sum, parent councils at public schools are uniquely situated as a civic educational institution and remain nearly absent from citizenship education initiatives in Europe. In an effort to illuminate the viability of parent councils for civic integration, this study utilizes a mixed-method framework to build a conceptual understanding through qualitative methods in the first phases of research which inform a representative survey of parent members in the final phase of the study.

Keywords: citizenship,parent councils,schools,adult civic education,immigrant citizenship education,civic integration,parent participation in schools
Social, complementary or community virtual currencies transfer of knowledge to SME: a new era for competitiveness and entrepreneurship (VirCoin2SME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Germany,Spain,Ecuador,Colombia,Belgium
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2014-12-01
End date: 2016-11-30
Duration (months): 24.0
Total project cost (EUR): 378000.0
EU funding (EUR): 378000.0
Participants: 6
Project status: CLOSED

With the advent of social networks and Mobile networks, new online communities are being created around sustainable topics (environmental, social, community development). The phenomena, known as digital social innovation, generates a positive ecosystem where business and social development enabled with new behaviours boosted by social, complementary or community currencies deployed as virtual currencies have a great potential for competitiveness, and entrepreneurship, but also for fostering social responsibility in Europe. VirCoin2SME projects aims at studying how the business development could be fully deployed around the ecosystem of social networks and virtual currencies, which facilities new exchanges for wealthier communities. Research objectives to be developed in VirCoin2SME project are: 1.To compare different models of social networks influence on business processes 2.To analyze the mechanisms behind the adoption of social, complementary or community virtual currencies. 3.To research on the potential impact of digital innovation and alternative currencies development in social, environmental and economic sustainability. 4.To develop two sector-oriented proposals/guidelines (healthcare and tourism) for developing sustainable business models based on the use of complementary and/or virtual currencies The previous research objectives will be achieved by implementing a collaborative working scheme where research entities will design the methodology and elaborate final guidelines to develop, according to the actual business scenarios defined and analyzed by the private companies involved in VirCoin2SME, in the two respective sectors that will act as use cases for study and proposals development: healthcare and tourism. Dissemination and communication activities will be designed and developed in parallel to ensure the wider impact of the knowledge generated and to foster new business generation around sustainable models not only in Europe,but internationally.

Keywords: social innovation,virtual currencies,enterpreneurship
Dynamic assembly and exchange of RNA polymerase II CTD factors (DECOR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Czechia
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-08-01
End date: 2020-07-31
Duration (months): 60.0
Total project cost (EUR): 1844603.75
EU funding (EUR): 1844603.75
Participants: 1
Project status: CLOSED

The C-terminal domain (CTD) of the RNA polymerase II (RNAPII) largest subunit coordinates co-transcriptional processing and it is decorated by many processing factors throughout the transcription cycle. The composition of this supramolecular assembly is diverse and highly dynamic. Many of the factors associate with RNAPII weakly and transiently, and the association is dictated by different post-translational modification patterns and conformational changes of the CTD. To determine how these accessory factors assemble and exchange on the CTD of RNAPII has remained a major challenge. Here, we aim to unravel the structural and mechanistic bases for the dynamic assembly of RNAPII CTD with its processing factors. Using NMR, we will determine high-resolution structures of several protein factors bound to the CTD carrying specific modifications. This will enable to decode how CTD modification patterns stimulate or prevent binding of a given processing factor. We will also establish the structural and mechanistic bases of proline isomerisation in the CTD that control the timing of isomer-specific protein-protein interactions. Next, we will combine NMR and SAXS approaches to unravel how the overall CTD structure is remodelled by binding of multiple copies of processing factors and how these factors cross-talk with each other. Finally, we will elucidate a mechanistic basis for the exchange of processing factors on the CTD. Our study will answer the long-standing questions of how the overall CTD structure is modulated on binding to processing factors, and whether these factors cross-talk and compete with each other. The level of detail that we aim to achieve is currently not available for any transient molecular assemblies of such complexity. In this respect, the project will also provide knowledge and methodology for further studies of large and highly flexible molecular assemblies that still remain poorly understood.

Keywords: rna polymerase ii,the ctd code,protein protein interactions,co transcriptional processing,nmr spectroscopy,saxs
microRNA replacement therapy for mature B cell neoplasias (HEAL-BY-MIRNA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-05-01
End date: 2017-10-31
Duration (months): 18.0
Total project cost (EUR): 149750.0
EU funding (EUR): 149750.0
Participants: 1
Project status: CLOSED

Mature B cell neoplasias include most of Non-Hodgkin Lymphomas (NHL), such as Diffuse Large B Cell Lymphomas and Burkitt Lymphoma and also B cell Chronic Lymphocytic Leukemia. It is estimated that about 60000-80000 new cases of mature B cell neoplasias are diagnosed every year in Europe. About 60% of NHL present with aggressive forms, and need immediate therapeutic action. The most common choice of treatment for mature B cell neoplasia is chemotherapy, and particularly the multidrug R-CHOP, but a fraction of the cancers either are refractory to these therapeutic interventions or relapse after treatment. Indeed, NHL is the cause of close to 26,000 deaths per year in Europe. Therefore, alternative therapeutic targets are imperative to replace or complement the current approaches. microRNAs (miRNAs) have arisen as extremely promising therapeutic tools in a number of diseases, including cancer. We have identified a miRNA specific of mature B cells whose expression is lost in mature B cell neoplasias. We found that re-introducing this miRNA in lymphoma cells in animal xenograft models leads to a dramatic block of tumor growth and extends mouse survival. Our studies show that this miRNA is therapeutically efficient not only in the form of lentiviral vectors but also as a synthetic miRNA mimic. Likewise, both intratumoral and systemic, intravenous delivery of miRNA mimic have yielded positive regression results. In addition, established lymphoma cell lines as well as primary mature B cell lymphomas have proved sensitive to miRNA treatment. Therefore, we propose to take to proof of concept the idea that miRNA replacement is an efficient therapeutic strategy for the treatment of mature B cell lymphomas. With this HEAL-BY-MIRNA proposal we aim at moving forward this idea to a stage where it can be exploited to have social impact and to become a marketable product.

Keywords: mirna,microrna replacement,chemotherapy,non hodgkin lymphoma,germinal centres
Multi-Organ UltraSound-based Inborn Evaluation (MOUSIE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-11-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Prenatal diagnosis of congenital abnormalities and intrauterine growth restriction (IGR) has become increasingly important thanks to the recent advancements in obstetrical ultrasound (US) imaging. An accurate and early diagnosis of fetal malformations and growth anomalies can improve fetal prognosis by allowing a treatment plan to be produced, enabling access to specialist units and appropriate treatments from birth. However, the diagnostic accuracy of US is limited due to its subjective assessment and inter-operator variability. On the other hand, magnetic resonance imaging (MRI) has the potential to offer a more detailed examination of the fetus. Unfortunately, its high cost, limited availability, and the difficulty in acquiring high quality 3D data due to constant fetal motion, hinder the widespread use of fetal MRI. The MOUSIE project aims at improving the accuracy of fetal US examination by creating the first framework for multi-organ quantitative image analysis of the fetus. In particular, the specific goals of the MOUSIE project are: (1) development of new multi-organ MRI slice to volume reconstruction method able to provide comprehensive and relevant 3D inter-organ information of the fetal anatomy, including spine, lungs, liver and kidneys; (2) development of an US-based automated segmentation method, using a detailed MRI-US atlas of the anatomy of the fetus of 18-20 weeks of gestational age, that includes new structural similarity patterns and inter-organ shape models; (3) creation of a new generation of multi-organ fetal biomarkers based on the detailed and comprehensive anatomical information extracted from a unique database with more than 500 MRI-US scans, including healthy and pathological cases. By achieving these goals, MOUSIE will provide an innovative set of methods allowing for the first time quantitative, noninvasive, objective assessment of the fetal anatomy and growth, and thus address a long standing clinical need for such methodology.

Keywords: prenatal screening,quantitative imaging,ultrasound,multi modal atlas,statistical shape model,multi organ analysis
Demonstration of soft stimulation treatments of geothermal reservoirs (DESTRESS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Germany,Germany,Germany,Switzerland,Korea, Republic of,Lithuania,France,France,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom
Call: Demonstration of renewable electricity and heating/cooling technologies (H2020-LCE-2015-2, 2015)
Start date: 2016-03-01
End date: 2021-05-31
Duration (months): 63.0
Total project cost (EUR): 24713964.19
EU funding (EUR): 10713408.629999999
Participants: 19
Project status: CLOSED

DESTRESS is aimed at creating EGS (Enhanced geothermal systems) reservoirs with sufficient permeability, fracture orientation and spacing for economic use of underground heat. The concepts are based on experience in previous projects, on scientific progress and developments in other fields, mainly the oil & gas sector. Recently developed stimulation methods will be adapted to geothermal needs, applied to new geothermal sites and prepared for the market uptake. Understanding of risks in each area (whether technological, in business processes, for particular business cases, or otherwise), risk ownership, and possible risk mitigation will be the scope of specific work packages. The DESTRESS concept takes into account the common and specific issues of different sites, representative for large parts of Europe, and will provide a generally applicable workflow for productivity enhancement measures. The main focus will be on stimulation treatments with minimized environmental hazard (“soft stimulation”), to enhance the reservoir in several geological settings covering granites, sandstones, and other rock types. The business cases will be shown with cost and benefit estimations based on the proven changes of the system performance, and the environmental footprint of treatments and operation of the site will be controlled. In particular, the public debate related to “fracking” will be addressed by applying specific concepts for the mitigation of damaging seismic effects while constructing a productive reservoir and operating a long-term sustainable system. Industrial participation is particularly pronounced in DESTRESS, including large energy suppliers as well as SMEs in the process of developing their sites. The composition of the consortium involving major knowledge institutes as well as key industry will guarantee the increase in technology performance of EGS as well as an accelerated time to market.

Keywords: reservoir engineering,modelling,monitoring,risk mitigation
The Influence of Information Search on Preference Formation and Choice (INSPiRE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Cost-benefit analyses are routinely used by policy makers when designing environmental policy to weigh the costs and benefits of different policy alternatives, and stated choice experiments are used to value the non-marketed costs and benefits included in such analyses. Standard practice in stated choice experiments is to create a hypothetical market environment in which people choose among competing policy alternatives under the assumptions that they have complete information about all available policy alternatives, and that they are perfectly rational and maximize utility based on a clearly defined set of preferences, which can be retrieved when needed in any choice situation. In reality, these assumptions are questionable. Drawing on accumulating evidence from economics, psychology and marketing, this project aims to understand how searching for information about policy alternatives affects stated preference formation, learning and choice, and the extent to which this can address hypothetical bias. The project develops a novel experimental procedure that addresses important issues in stated choice experiments and make significant and original methodological contributions that advance current practice beyond state-of-the-art in both experimental design and data analysis. Improving the reliability of stated choice experiments will lead to improved estimates of non-marketed costs and benefits included in cost-benefit analyses. Through a broad uptake and use of these methods by stated preference practitioners, and increased awareness among policy makers, the methodological developments in this project can lead to improved policy recommendations and implementation across the EU.

Keywords: stated preferences,behavioral economics,discrete choices,choice modeling