Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Evaluation of NDT Techniques for Assessment of Critical Process and Manufacturing Related Flaws and Defects for a Ti-alloy (3TANIUM)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Austria,Austria,Hungary,Czechia
Call: Evaluation of NDT Techniques for Assessment of Critical Process and Manufacturing Related Flaws and Defects for a Ti-alloy (H2020-CS2-CFP11-2020-01, 2020)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 550000.0
EU funding (EUR): 550000.0
Participants: 4
Project status: CLOSED

To improve aircraft resource-efficiency and to decrease fuel consumption and CO2 emissions innovative solutions with superior mechanical properties for advanced structures are in development. Ti6Al4V alloys, due to a high strength-to-weight ratio compared to steel or aluminium can keep the structural weight and size ratio low. However, lightweight construction with this alloy is currently only possible with conventional techniques as CNC machining, casting that lead to a high proportion of raw material removal. This is not cost-efficient and works with a high ecological footprint. A primary alternative for fabrication of advanced functional lightweight metallic parts is additive manufacturing (AM), offering benefits in terms of weight, design and functionality, lead time and cost/manufacturability and allowing for alternative geometric shapes, thereby decreasing the weight of the component without sacrificing component strength and safety. However, AM has not yet been approved for structural components with high safety requirements to date, as there are still technology gaps: material property control, correlation between process and structural properties, effect of defects, quality control. Material and mechanical properties of AM parts differ substantially from the properties of the same parts produced by conventional casting. Therefore, a damage tolerance assessment needs to be performed for AM parts in commercial aircraft applications to meet functional and safety requirements. The main objective of the 3TANIUM is the establishment of NDT methods that are capable to provide the secure detection of process related critical flaws and defects and to understand their effects on material and mechanical properties in Ti6Al4V AM parts. 3TANIUM will quantitatively assess the applicability of NDT methods applied on appropriately and innovatively post-treated (heat- and surface-treated) AM parts in order to realize benefits offered by AM in the aeronautical industry.

Keywords: additive manufacturing,titanium alloys,non destructive testing,safety requirements,aeronautical industry,reduced fuel consumption and carbon dioxide emission
The bargaining power of sending countries in influencing the rights of their low skilled migrant workers (RIGHTS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2024-08-31
Duration (months): 78.0
Total project cost (EUR): 1346156.0
EU funding (EUR): 1346156.0
Participants: 1
Project status: SIGNED

This project asks how governments of migrant sending countries can influence the rights of their low skilled migrant workers in receiving countries. The project approaches this question from both the sending and the receiving country side; looking at factors that determine when and how sending states intervene and what determines the responses from receiving countries. The surplus of aspiring migrants and economic importance of remittances would suggest sending states have little bargaining power. Single case studies however suggest that some nevertheless intervene. A comprehensive overview of the drivers of immigration and emigration policy will result in a set of hypotheses. A survey of policy makers in sending countries will generate an overview of interventions by sending country governments. The project’s core is a systematic comparative case study of six sending countries with partly overlapping receiving countries and three of these receiving countries. The sending country cases are three sets of two countries in which migrant remittances constitute a similar share of GDP but involvement with the rights of their workers abroad differ; the Philippines, Senegal, India, Ecuador, Morocco and Vietnam. The receiving countries are South Korea, Saudi Arabia and Italy. These countries vary strongly in the rights for migrant workers and the level of cooperation with sending states. QCA and process tracing will be used to assess the hypotheses. The project is innovative in 1) providing a systematic analysis of a larger number of cases including countries rarely covered in comparative studies on migrant rights, 2) examining of the actions of both sending and receiving countries, and 3) taking the trade-off between migrant numbers and rights into account. The project will push theory development forward by connecting theoretical fields and expanding geographic scope. It is policy-relevant by providing further insight into how the rights of migrant workers can be improved.

Keywords: migration policies,international migration,sending countries,low skilled migrant workers,policy development
A neurosplenic pathway coupling Immunity and Hypertension (SymPAtHY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Italy
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-12-01
End date: 2022-11-30
Duration (months): 60.0
Total project cost (EUR): 1497831.0
EU funding (EUR): 1497831.0
Participants: 1
Project status: CLOSED

Hypertension (HTN) is a leading cause of morbidity and mortality worldwide. During past decades, several therapies have been developed to afford an optimal blood pressure (BP) regulation. However, the prevalence of uncontrolled HTN continues to rise, with a number of patients still resistant to all ongoing antihypertensive treatments, raising unsolved mechanistic challenges. In the last years, the most attractive novelty in HTN postulated that immune system has a crucial role in BP raising, as well as in end-organ damage. Several advances have been done in this field, but clear mechanistic explanations of how the immune system gets activated under hypertensive challenges is still unknown. It is becoming increasingly clear that, even in the regulation of body hemodynamic, the immune system and the autonomic nervous system serve as two major “sensory organs” capable to be activated upon manifold hits that perturb homeostasis. SymPAtHY is a multidisciplinary strategy aimed at discovering how nervous and immune systems couple in HTN. The concept of this project is to dissect the neuro-immune pathway responsible for BP rising and end-organ damage. The articulation in 3 MAIN AIMS will allow to afford the mechanistic insights from different perspectives. The overall objectives are as follows: 1) Central nervous system relay station coupling immunity and hypertension. 2) Splenic immune mechanisms: from sympathetic drive to T cell egress; 3) T cells in target organs: from the spleen to vessels and kidney. The results of this strategy will unravel important new mechanistic insights in HTN and particularly will have significant implications for understanding how immunity and autonomic nervous system cooperate to rise BP. Based on the emerging view of HTN as an “immune disorder”, we believe that this strategy will add decisive knowledge in this field that could pave the way for developing immunotherapies for the treatment of resistant HTN.

Keywords: autonomic nervous system,splenic immune system,vascular biology
Predictive Simulation of Defects in Structural Composites (PSIDESC)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Belgium,Belgium
Call: Numerical methodologies and related tools for effect of defect prediction in manufacturing (H2020-CS2-CFP04-2016-02, 2016)
Start date: 2017-06-01
End date: 2021-05-31
Duration (months): 48.0
Total project cost (EUR): 511338.75
EU funding (EUR): 511338.75
Participants: 3
Project status: CLOSED

PSIDESC (Predictive Simulation of Defects in Structural Composites) will aim at bringing new methodologies and deployable toolkits for robust design of composite parts and structures with respect to tolerances and defects that are related to the manufacturing process. The objective is to push acceptable means of compliance based on simulation capable of predicting the range of response that a part may have under uncertainty. Predictive virtual testing including factors of variability coming from the manufacturing phase will: - reduce the scrapping of parts (through virtual assessment); - reduce the need for full inspection of parts; - enhance design and enable further weight savings with a better understanding of effect of variability on the behavior and defect tolerance of different areas of a part.

Keywords: predictive virtual testing,defect characterization,multi scale modeling,stochastic analysis,structural integrity
Identification of quantum resources in thermodynamic systems (QQT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-03
End date: 2020-04-02
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

In this proposal we look at thermodynamics in extreme regimes, i.e. out of equilibrium quantum systems displaying coherence and entanglement, far from the thermodynamic limit and in single-shot scenarios. The main objectives are: 1) Creation of a thermodynamic dictionary that reconciles the resource-theoretical formalism with the variety of approaches to the field, clarifying the scope of abstract results in experimentally relevant scenarios, including restricted control and finite-time constraints. 2) Inclusion of quantum coherence and correlations in extreme quantum regime, beyond simple energy quantisation. We propose a new paradigm looking at the interplay of coherence and entanglement in thermodynamics and explore its consequences for cooling protocols and non-locality. 3) Presenting clear evidence of genuine non-classicality in thermodynamics. With the ultimate goal of providing a framework to achieve non-classical advantages, we propose to establish a new research venue looking at signatures of quantum contextuality in thermodynamics. We propose to devise experimentally testable protocols whose statistics defies any non-contextual explanation. This highly innovative proposal will be carried out with a host of world experts coordinated and led by the fellow. The great interdisciplinary content will significantly extend the applicant's expertise in the diverse areas of quantum thermodynamics, but also in contextuality, non-locality and their applications to computing and cryptography. Within a world-class institute like ICFO, the networking opportunities, involvement in the PhD programme and the training offered will allow the fellow to acquire the flexibility, critical thinking, broad horizon and supervision skills required to eventually lead a research group, either in academia or hi-tech industry.

Keywords: quantum thermodynamics,quantum information theory,quantum contextuality,non locality
Dopaminergic midbrain modulations by (adaptive) neurofeedback (DOPANF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Value-based decision-making is crucial for human behavior and learning, pervades our daily life and goes astray in psychiatric disorders such as schizophrenia and depression. The neural activity of brain regions producing and being influenced by the neurotransmitter dopamine has been associated with value-based decision-making processes. By extension, one would expect dopamine systems, mainly midbrain regions and their striatal projections, to play a role in such decisions, such as whether a specific reward is worth enduring some punishment. It is a matter of debate, but of surprisingly little empirical investigation, whether the rewarding and punishing aspects of value differentially or similarly depend on the dopamine system. The project DOPANF aims to clarify this issue by investigating dynamic changes of dopamine-related neural activity. DOPANF develops two new paradigms to shed light on this important, yet neglected topic for public health and subjective well-being. Specifically, DOPANF uses recent neuroscientific and technological developments: real-time imaging for immediate analysis of neural activity in the midbrain and multivariate pattern analysis for algorithmic capture of related activity spatially distributed throughout the brain. By observing their own brain activity as neurofeedback in real time, participants will learn to volitionally up- and downregulate activity in the dopamine system. We will then measure the behavioral consequences of this regulation with regard to how much effort participants are willing to exert to obtain a reward. Thus, DOPANF aims to achieve a more precise understanding of decision-making behavior and elucidate the exact role of the dopaminergic midbrain in value processing and its impact on effort discounting. The project is feasible and has the potential to provide a better understanding of psychiatric diseases, such as depression or schizophrenia.

Keywords: value based decision making,dopaminergic midbrain,adaptive neurofeedback,multi variate pattern analysis
High resolution X-ray detectors based on nanowire arrays (WIREDETECT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2024-07-31
Duration (months): 66.0
Total project cost (EUR): 1498971.0
EU funding (EUR): 1498971.0
Participants: 1
Project status: SIGNED

In this project I will develop ultra-high resolution X-ray detectors based on semiconductor nanowires, whose spatial resolution will be radically better than the current state of the art. In X-ray detectors the primary X-ray absorption induces a cascade of secondary electrons and photons which are measured at the front or back of the detector, but during the long transport to the point of detection these can spread orthogonally to the optical axis. This limits the resolution in present bulk detectors. My novel concept is to create a nanostructured detector based on an array of semiconductor nanowires, which will confine and physically prevent spreading of the secondary electrons and photons. In a nanowire array, the pixel size is the diameter of the nanowire, which can be as low as 10 nm, while the nanowires can be as long as the X-ray absorption length. The very high aspect ratio of nanowires allows detectors with simultaneously very high spatial resolution and sensitivity. I will investigate both direct detectors and scintillators, in which the secondary electrons and photons are detected, respectively. The objective is to create detectors based on arrays of 10 nm-diameter nanowires. Time- and temperature resolved measurements will be used to improve understanding of the X-ray physics in these nanodevices, with strong quantum confinement of electrons and phonons and high surface to volume ratio. I will test the detectors within an imaging project targeting the neural connectome, and compare the nanowire detectors with commercial ones. This novel detector concept could revolutionize high-resolution imaging of samples on the nanoscale, maintaining the unique ability of X-rays to study samples in realistic conditions: DNA within live cells, the strained channel in single operational transistors or individual nanoparticles in a charging battery. High resolution detectors could also be employed in X-ray spectroscopy and diffraction.

Keywords: x ray,detector,nanowire,imaging
Unveiling the true historical and biological origins of key phenotypes in modern domestic horses (HOPE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-12
End date: 2023-07-11
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

The horse provided humankind with the ability to travel well above its own speed and changed the face of warfare, and the geographic expansion of people, languages and culture. As such, the domestication of the horse some 5,500 years ago represents not less than a turning point in human history. While domestication shaped a great diversity of horse phenotypes, fit for a wealth of human purpose, many of the underlying causative genetic variants, and the geographic and temporal locus of their associated native breeding centers remain unclear. The HOPE project is aimed at the identification and functional validation of genetic innovations that have accompanied the birth and spread of important phenotypic traits during the history of modern domestic horses. Our methodology will leverage state-of-the-art methodologies in two complementary research fields, each synergizing the core expertise of the supervising host and postdoctoral fellow. These will first consist of using the ancient DNA and population genomics toolkits for shortlisting genomic variants candidates for driving important phenotypic features, and second harnessing the full power of functional genomics to measure some of their biological mechanism in cellular. The HOPE project will, thus, fill an important gap in our knowledge of horse evolution and will mark the birth of a new era in archeo-genomics, moving away from the sole description of putative adaptive markers, currently limiting most common studies, to the investigation of the conformational, performance, physiological and medical in living animals.

Keywords: ancient dna,horse domestication,phenotype evolution,functional validation,biological mechanism
Huple movement and coordination development tool (HUPLE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Hungary
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

HUPLE provides early intervention and complex therapy for children with movement disorders, mostly resulting from birth injuries – and also to help healthy children improve their balance and coordination ability. It has already been used on 75,000 children with more than 50% of them successfully rehabilitated. HUPLE is a patented (EU & US) hemisphere shaped balance swing that helps the development of dynamic stability of the head-trunk-pelvis unit through isolated and complex vestibular stimulation. It is used as rehabilitation tool for children with movement disorders and as a development tool for healthy new-borns, children and adults alike. It incorporates decades of knowledge and experience of improving dynamic stability handicapped children gained by the Gezenguz Foundation (which was set up by the inventor of HUPLE in 1990). Since its first release, the demand for HUPLE has increased tenfold without any emphasis on commercial activities limited by the production capacity. Furthermore, there is a lot of interest from therapy and rehabilitation centres across Europe who already use HUPLE and are demanding larger quantities with enhancements to improve the effectiveness of the therapy based on the work that has been carried out by our partner BME. This work focused on using 3D orientation sensors attached to HUPLE and using AI-based analytical, predictive and other therapy support software elements with corresponding hardware applications to make the assessment more reliable and to make it more acceptable and likeable by children through special games. The aim of the Phase 1 feasibility study is to identify suitable business model that allows the manufacturing of HUPLE to become scalable in order to satisfy the demand of the market and to create a corresponding business and commercialisation plan for the sensor enhanced HUPLE product based on updated market analysis and customer need.

Keywords: child diagnostics and therapy,birth injury rehabilitation,sensor technology,manufacturing processes,injection molding