Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DataMall (Behavee) is an open ecosystem for the eCommerce cyberspace (HuMaInn DataMall)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Czechia
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2018-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Executive Summary Data age is here. Every human endeavor is generating data and is influenced by various data inputs. Actual market state of data sources today is “closed, fragmented, private and non-structured”. At HuMaInn, we are committed to make a difference & disrupt this market - we make innovations for People through technology: Human Machine Innovations. We challenge the Digital Advertising paradigm of ineffective business models where companies are charged per view and not per sales transactions. We connect businesses and let them share their verticals to enrich entire value chains. Our technology is based on Open Source and running in Cloud. Its scalability is simplified due to digital platform-based business model, thus entering into new segments and geographic markets is a matter of marginal costs. We are committed to build an open ecosystem for the eCommerce cyberspace, enabling small companies to compete fairly with big players, by building on microsegment anonymized information/data to offer the best possible and relevant offers. We are one of the revolutionary solutions that will impact Digital Economy agenda, via instant understanding of customer behavior. Our algorithm is constantly improved via Machine Learning, with each new transaction and each new segment, the data validity growth exponentially. Our commercial pilot is running as you read this proposal, adding results to the vast database of customers journeys.

Keywords: open,ecosystem,ecommerce,cyberspace,anonymized microsegment,next best offer,recommendation
Erasing the superintegron to understand the role of chromosomal integrons in bacterial evolution (KryptonInt)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Spain
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2025-04-30
Duration (months): 76.0
Total project cost (EUR): 1499516.0
EU funding (EUR): 1499516.0
Participants: 1
Project status: SIGNED

Integrons are genetic platforms that enhance bacterial evolvability through the acquisition and stockpiling of new genes encoded in mobile elements named cassettes. They are found in the chromosomes of environmental bacteria but some have acquired mobility through their association to transposons and conjugative plasmids. These mobile integrons (MI) caused the unexpected rise of multidrug resistance that is now a major threat to modern medicine, and are good proof of the adaptive power of integrons. Class 1 integrons are the most relevant MI and the major experimental model. Yet little is known about the hundreds of sedentary chromosomal integrons (SCI) that have driven bacterial evolution for eons. The paradigm of SCI is the superintegron (SI), an extremely large integron located in the chromosome of Vibrio cholerae, the causative agent of Cholera disease. Despite its role in the adaptability of one of the deadliest pathogens in history, the SI is poorly characterized because it is only functional in its native genetic background, yet its presence interferes with, and precludes all studies performed in V. cholerae. I propose to solve this paradoxical situation by deleting the SI, an ambitious project not only for its size (126 Kb) but because it is highly stabilized by 17 toxin-antitoxin systems. To do so, I have developed SeqDelTA, a novel method that is already giving excellent preliminary results. I will then use V. cholerae∆SI to study fundamental aspects of SCIs, yet out of reach. I will elucidate the functions encoded in SI cassettes to understand the role and adaptive value of integrons in nature; I will also unravel the genesis of cassettes: how a gene is exapted from its genetic context to become a mobile module; and I will explore the circulation of antibiotic resistance cassettes among humans, animals, food, and the environment with a novel biosynthetic tool (the I3C). KryptonInt will open and explore the historically inaccessible field of study of SCIs.

Keywords: phenomics,integron,antibiotic resistance
Multi-fidelity design optimization of long-span bridges considering probabilistic wind-induced instabilities of flutter and buffeting and hydrodynamics (MFOptBF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-20
End date: 2020-08-19
Duration (months): 24.0
Total project cost (EUR): 208400.4
EU funding (EUR): 208400.4
Participants: 1
Project status: CLOSED

Efficient transport structure is considered as fundamental for the economic growth and social cohesion of communities. Long-span suspension bridges have served to cross large physical barriers for decades as one of the most challenging structures in civil engineering. Several major suspension bridges are currently under planning; Coastal Highway E39 Route in Norway with floating foundation, Canakkale Bridge in Turkey, Tokyo Bay Bridge in Japan to name a few. The span length of suspension bridges has become longer with the advances in construction technologies, yet the bridge structures become more flexible and more prone to wind-induced vibrations, which are key concepts for the bridge design. For the construction of long-span bridges, huge material cost is required, and the reduction in material will be of great interest. The design optimization is a mathematical method of minimizing a cost function while satisfying structural requirements. Reliability Based Design Optimization (RBDO) performs design optimization while uncertainty in parameters are considered, producing more accurate optimum solutions; however, it has a drawback of high computational cost. In recent years, multi-fidelity optimization has attracted attention of researchers for a clear improvement of efficiency. The candidate has worked on RBDO of long-span bridges under probabilistic flutter in her thesis. She would like to expand her research by proposing multi-fidelity optimization method considering probabilistic wind-induced bridge vibrations accounting also for the hydrodynamics effects, and applying the method to on-going bridge projects. This research project is challenging for the incorporation of probabilistic buffeting and hydrodynamics effects. It is multidisciplinary involving in mathematical discipline of design optimization, wind, structural and marine engineering. This project will help to form efficient transport in the EU by providing method for the sustainable bridge designs.

Keywords: reliability based design optimization,multi fidelity,aeroelasticity,flutter,buffeting,hydrodynamics,long span bridge,wind induced instabilities
3D Printed-Matrix Assisted Chemically Modified RNAs Bone Regenerative Therapy for Trauma and Osteoporotic Patients (cmRNAbone)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Austria,Germany,Germany,Switzerland,Switzerland,France,France,France,Netherlands,Netherlands
Call: Regenerative medicine: from new insights to new applications (H2020-SC1-2019-Single-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2024-06-30
Duration (months): 54.0
Total project cost (EUR): 6256758.75
EU funding (EUR): 6256758.75
Participants: 14
Project status: SIGNED

Due to life style changes and ageing of our industrialized nations, bone traumatic injuries and osteoporosis induced fragile fracture are an enormous medical and socio-economic challenge. State-of-the-art therapies have failed until now in keeping their promises of reliable bone regenerative solutions. The cmRNAbone project aim to create a novel bone regenerative therapeutic approach based on combination of chemically modified RNAs (cmRNAs)-vectors embedded in a 3D-printed guiding biomaterial ink tailored to patients need. To achieve our goal, sema3a, vegf, pdgf-bb and bmp7 cmRNAs targeting neurogenesis, vasculogenesis and osteogenesis will be synthesized, vectors based on lipids and polysaccharide nanocapsules for the delivery of cmRNAs will be developed. A functional Hyaluronan-Calcium Phosphate biomaterial ink that 1) can be loaded with cmRNAs-vectors and release them, 2) having intrinsic osteoinductivity and presenting laminin-derived peptides for guiding sensory neurons and endothelial cells ingrowth, and 3) being amenable to an extrusion-based 3D-bioprinting process will be formulated in conjunction to a 3D-printer for fabrication of patient specific regenerative solution. In the following step, a large effort will focus on deciphering regenerative mechanisms and optimizing dosage and ratio of cmRNAs, loading of cmRNAs-vectors in the ink, 3D-printing, etc, to demonstrate regenerative capabilities in vitro and in vivo. Selected candidate formulations will be taken to clinically relevant preclinical proof of concepts. Finally, an overreaching effort on preparing a 1st in human trial will be taken, consisting on partners facilities auditing and clinical experts group support, etc, to ensure that GMP-like production for all regenerative tools, and regulatory and commercial strategies are realized.

Keywords: gene therapy,vectors,gene activated matrix,3d printing,use of combined products,neurogenesis,vasculogenesis,osteogenesis,regenerative mechanisms,regulatory strategy
Trehalose as a source for privileged immunity in Drosophila (IMMUNETREH)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Czechia
Call: Widening Fellowships (H2020-WF-01-2018, 2018)
Start date: 2020-01-01
End date: 2023-02-12
Duration (months): 24.0
Total project cost (EUR): 156980.64
EU funding (EUR): 156980.64
Participants: 1
Project status: CLOSED

The immune response is an energy demanding process and immune cells must have a privileged access to energy/nutrients. While in mammalian system, this privileged access is achieved for example by insulin-independent glucose transporter, how is it achieved in insect is not known. The host laboratory has obtained preliminary results suggesting that the privileged access of fruit fly immune cells to nutrients might be achieved by using trehalose instead of glucose. It is known for a very long time that the primary sugar in insect is trehalose but it is a completely new idea that this carbohydrate could actually play an important role in the privileged access of immunity to resources, as in one of the most fundamental evolutionary trait. The goal of this project is therefore to test if activated Drosophila immune cells preferentially uptake trehalose and convert it to glucose intracellularly, being thus independent of the systemic carbohydrate regulation, and how important would it be for an efficient immune response. The project is based on a multidisciplinary approaches, when tissue-specific genetic tools will be used to manipulate metabolism in vivo in order to study immune response using techniques of molecular biology, developmental biology and immunology and state-of-the-art metabolic approaches. The goal for the researcher is to learn how to use Drosophila genetics and the infection models, well established in the host laboratory, and combine them with her expertise in insect physiology, cell culture and especially metabolomics.

Keywords: immunometabolism,drosophila,trehalose
The first eco-friendly technology for greasy mixed plastics recycling (EGREMPLARE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Owing to their combination of unrivaled properties and low cost, plastics are the workhorse material of the modern economy. While delivering many benefits, the current plastics economy has drawbacks that are becoming more apparent by the day. The primary problem is the high material waste rate and poor closed-loop recycling in plastics manufacturing. Today, just 14% of plastics are used for recycling. To cope this problem, the European Commission has tried to implement increasingly stringent regulations, such as reducing landfilling or incineration, by increasing the taxes for waste disposal and promoting recycling. Nevertheless, the current inefficient recycling technologies make plastics recycled uncompetitive as raw material for many plastics converters. At TUSTI. BV. (Eindhoven, Netherlands) we have developed a smart solution to overcome these barriers. EGREMPLARE high-tech recycling process is a novel process that makes recycling of mixed plastics possible, allowing to increase to 60-85% the collected plastics to be recycled. We use our proprietary cleaning process that uses a bio-based material without not generation of new waste streams and with a low energy consumption. Companies have to pay less than landfilling taxes, contributing to the achievement of objectives set by the European Commission and reducing disposal cost. Since our foundation in 2015, we have invested over 350,000 euros to develop pilots tests, the bio-based cleaner, and process improvements. Now, based on the good results of our system, we aim to speed-up the technology to introduce our solution in the plastic recycled market. This market with such growth potential (predicted to increase at 6% CAGR up to 2022 reaching €42B), could greatly benefit from our eco-friendly and low-energy solution. We aim to achieve sales of 12,000 tonnes of plastic waste collected and over 10,000 of plastics recycled in the third year of commercialization, with revenues of more than 6 M€ by 2023.

Keywords: plastics,recycling,bio based material,plastic waste,mixed plastic
Responsive Engagement of the Elderly promoting Activity and Customized Healthcare (REACH2020)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Switzerland,Sweden,Switzerland,Poland,Netherlands,Denmark,Denmark
Call: Advancing active and healthy ageing with ICT: Early risk detection and intervention (H2020-PHC-2015-single-stage, 2015)
Start date: 2016-02-01
End date: 2020-01-31
Duration (months): 48.0
Total project cost (EUR): 6078657.5
EU funding (EUR): 4588315.0
Participants: 18
Project status: CLOSED

The health expenditure in the EU is expected to rise by 350% by 2050 compared to an economic expansion of only 180% and the provision of Long Term Care (LTC) will pose an increasing challenge to the sustainability of public finances in the EU, due to an ageing population. REACH therefore represents a solution that seeks to prevent elderly citizens from loss of function and a decline of being able to perform Activities of Daily Living (ADLs) independently leading ultimately to entering LTC. REACH is a personalized prevention and intervention system that promotes the activity of the elderly by monitoring and evaluating their daily habits, considering both personal medical history as well as real-time gathered data from a series of wearable and embedded sensors, in order to mitigate loss of function and to arrest associated and/or consequential morbidities via a number of physical and virtual activity intervention modules. REACH is an open solution that proposes its own innovative systems while remaining compatible with existing sensing systems and technologies. This is demonstrated by REACH’s cross-compatibility and integration of Philips’ HealthSuite Digital Platform (HSDP). Both REACH functioanlity and additional services by stakeholders and 3rd parties via the HSDP are inserted into the target environment through compact, preconfigurable and easily deployable smart furniture :Personalised Interior Intelligent Units (PI²Us). All consortium partners join their combined knowledge and developed expertise to fully deploy REACH in a naturalistic use-case environment via Lyngby. REACH entails multiple benefits for the elderly and for care systems it contributes to a significant reduction of cost though reducing the amount of doctor’s care and LTC admissions. REACH will allow European industry including SMEs to capitalise on the European high-tech-knowhow and make Europe a market leader in prevention technologies, services and underlying health care ICT platforms.

Keywords: activation,prevention of loss of function,product service systems,multi stakeholder collaboration,ict platforms,smart environments,smart furniture
SUPporting high quality evaluation of COVID-19 convalescent Plasma thrOughoutT Europe (SUPPORT-E)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Italy,Italy,Switzerland,Belgium,France,Netherlands,Denmark,Denmark,United Kingdom
Call: Advancing knowledge for the clinical and public health response to the 2019-nCoV epidemic (H2020-IBA-SC1-CORONAVIRUS-2020-3, 2020)
Start date: 2020-07-01
End date: 2023-06-30
Duration (months): 36.0
Total project cost (EUR): 4021277.0
EU funding (EUR): 4021277.0
Participants: 12
Project status: SIGNED

Coronavirus disease 19 (COVID-19) is provoking the greatest global health crisis of this generation. With no vaccine or specific antiviral treatment available to date, the use of convalescent plasma (CP) from recovered COVID-19 patients has been considered a potential curative strategy. To demonstrate its efficacy and safety, clinical studies are ongoing or planned in various EU Member States. Unfortunately, there lacks a coordinated approach involving a large number of blood establishments (BEs) and clinical centres to harmonise protocols and guidelines, to standardise assays for characterising the potency of the plasma and to validate clinical outcome which will be of great importance to ensure that significant conclusions can be drawn. SUPPORT-E brings together major European BEs with world leading research capabilities with the aim to support high quality clinical and scientific evaluation of COVID-19 CP (CCP) and thereby achieve a consensus on the appropriate use of CCP in the treatment of COVID-19 across EU Member States. Hence, SUPPORT-E will advance the current state-of-the-art by delivering the much needed harmonised evidence-based recommendations with respect to the use of CPP in clinical trials and monitored access programmes for COVID-19 patients in Europe. Further, standardised informative in vitro assays providing scientific insights that could support such recommendations will also be developed. SUPPORT-E offers an EU-wide collaboration between Member States, BEs and clinical centres in order to close the knowledge gap and to ensure applicability of the recommendations for all EU Members States. SUPPORT-E represents the first European Union coordinated research effort on passive immunotherapy, sharing data and protocols in real-time and pooling efforts to decrease the time as much as possible for validating CCP as a valid therapeutic treatment and also providing a basis for further optimisation by combined approaches with other anti-viral treatments.

Keywords: coronavirus,covid 19,sars cov 2,convalescent plasma,plasma potency,passive immunotherapy
Hard probes of heavy-ion collisions (HPOFHIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Czechia
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 156980.64
EU funding (EUR): 156980.64
Participants: 1
Project status: CLOSED

Heavy-ion collisions at collider energies are performed in order to produce and study QCD matter at high temperature, the quark-gluon plasma (QGP). Such an extreme state of matter is believed to have existed during the first microseconds after the Big Bang. The QGP and properties of strong force can be probed on a variety of length scales by jets, collimated sprays of particles originating from scattered quarks and gluons. The intent of this proposal is to study how high-energy quarks and gluons interact with the QGP and to better understand the mechanism of energy loss as they traverse the QGP. The investigators will focus on studies of jet substructure using contemporary substructure techniques as well as exploiting the role of flavour, jets size, and path-length dependence using new probes involving boosted objects. The project includes both experimental measurements and phenomenological investigations using existing models and their improvement.

Keywords: heavy ion collisions,jet quenching,jet structure,jet substructure