Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Fire Ignition Risk Evaluation, Spreading, Transport, Operational Response and Modelling. (FIRESTORM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-16
End date: 2028-01-15
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: SIGNED

Wildfires are increasing around the globe in frequency, severity and duration, increasing the need to understand their primary effects on ecosystems and human health. Furthermore, wildfires trigger or enhance a range of secondary hazards (e.g. floods, ash and phosphorus dispersion); also, wildfire's byproducts can be transported over long distances, with harmful effects on soil chemistry, air and water quality. The aim of FIRESTORM is the development of the first comprehensive system that integrates fire ignition from both natural and anthropic sources, fire spread and atmospheric dispersion (including fire byproducts and pollutants) at local, regional and global scale to assess primary and secondary hazards, enabling proactive measures for fire prevention (e.g. firebreaks). In addition, FIRESTORM’s features possible outlooks include the characterization of a range of anthropogenic or natural ignition scenarios (e.g. fires caused by lightning strikes, lava flows, volcanic pyroclastic material fallouts and earthquakes), auto-detection of new fires using satellite remote sensing, integration with other hazard models and maps, both natural (e.g. volcanic, seismic and weather-related maps) and anthropic (e.g. pollutant fallouts). This will be delivered through 5 Work Packages (WPs): the first three focus on the development and coupling of fire-air models; the fourth and the fifth are dedicated to the implementation and deployment of the system and its validation, respectively. FIRESTORM will therefore make a step forward in the state of the art, being the first multi-scale system capable of modelling and coupling fire and atmospheric flows, in order to provide short and long term hazard scenarios, which play a crucial role in civil defense, both for emergency management and for risk mitigation.

Keywords: fire wildfires wind multiscale transport hpc gpu supercomputing
Biocompatible polymer fibre temperature monitoring of therapeutic hypothermia in spinal cord injuries (BioPHIX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark,Cyprus
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 247553.28
EU funding (EUR): 247553.28
Participants: 2
Project status: SIGNED

BioPHIX aims to advance spinal cord injury (SCI) treatment, making the development of precise, biocompatible, and reliable temperature monitoring solutions a significant step forward in optimizing therapeutic hypothermia protocols. BioPHIX will design a novel polymer fibre temperature sensor capable for immediate implantation within the patient for prolonged observation of the patient’s physiological responses, during therapeutic hypothermia in SCIs, both during and post operation. This device will address one of the most vital shortcomings of the current temperature sensors; the ability to remain for an extended duration within the patient by minimizing the effect of a foreign body reaction response (FBR). The biocompatible polymer sensing device will achieve just that, while, at the same time augmenting the performance of the current state-of-the-art by combining the benefits of unique polymer materials with femtosecond lasers to facilitate the unique sensing structure.

Keywords: polymer fibres fabrication,optical fibre sensors,femtosecond laser material modification
Tracking the Evolution and dynamicS of Intermediate-mass black holes to Forecast their upcoming observAtions (TESIFA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2026-10-31
Duration (months): 36.0
Total project cost (EUR): 288859.2
EU funding (EUR): 288859.2
Participants: 2
Project status: CLOSED

In the next few years, electromagnetic and gravitational-wave facilities will uncover the elusive population of intermediate-mass black holes (IMBHs), the likely progenitors of present-day supermassive black holes. The upcoming detections promise to revolutionise our understanding of the black-hole population across the cosmic epochs; in preparation for this exciting future, it is now fundamental to shed light on the debated dynamical processes governing the growth of IMBHs. TESIFA is the long-awaited program that will clarify the timespan black holes spend in the intermediate-mass range, thus allowing for a solid interpretation of the upcoming IMBH detections. Leveraging the emergent picture according to which IMBHs primarily grow via stellar accretion, TESIFA will numerically model the rates of tidal disruption events (TDEs, thousands of which will be detected by the Vera Rubin Observatory starting next year) and gravitational-wave-induced extreme mass ratio inspirals (EMRIs, accessible to the planned LISA mission) about IMBHs. By combining this approach with state-of-the-art observations of nearby stellar systems, TESIFA will place novel constraints on the local IMBH population. Furthermore, TESIFA will investigate the ratio between TDE and EMRI rates as a function of the host galaxy properties, so that the observed TDE rates could be used to forecast LISA EMRI rates. Overall, TESIFA will lay the foundation for understanding the IMBH demographics and best exploiting their upcoming observations. At Princeton University, the fellow will work alongside world-leading experts in the field of IMBH observations; she will learn the challenges affecting the observations of IMBHs and their hosts, as well as the capabilities and limits of electromagnetic facilities. The planned training will perfectly complement the fellow’s extensive numerical expertise, making her a well rounded scientist and placing her at the forefront of the research targeting IMBHs.

Keywords: stellar dynamics collisional,intermediate mass black holes,n body simulations,fokker planck approach,tidal disruption events,extreme mass ratio inspirals,nuclear clusters,globular clusters
European Research Infrastructure for Heritage Science Implementation Phase (E-RIHS IP)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Italy,Belgium,France,Romania,Slovenia,Spain,Cyprus,United Kingdom,Greece,Hungary,Malta,Netherlands,Poland,Portugal
Call: Consolidation of the research infrastructure landscape – Individual support for ESFRI projects (HORIZON-INFRA-2021-DEV-02, 2021)
Start date: 2022-10-01
End date: 2024-12-31
Duration (months): 27.0
Total project cost (EUR): 1698316.25
EU funding (EUR): 1353600.0
Participants: 19
Project status: CLOSED

The European Research Infrastructure for Heritage Science (E-RIHS) was designed as a pan-European distributed infrastructure with the vision of replacing the traditional science-for-art approach to conservation through the new widely interdisciplinary sector of Heritage Science (HS) to improve the understanding and sustainable preservation of cultural heritage. E-RIHS was admitted in the 2016 ESFRI Roadmap and is now preparing its step 2 application to take the legal form of an ERIC. The E-RIHS Implementation Phase (E-RIHS IP) consortium brings together representatives of the national nodes of the countries that expressed their willingness to support the establishment of the ERIC and one permanent observer. It aims at enabling the E-RIHS implementation phase and preparing the operation of E-RIHS ERIC, also in support of its positioning as the reference RI for the HS domain at the EU and global level. The objectives and methodology underpinning the E-RIHS IP work plan target and intend to overcome the bottlenecks highlighted in the recommendations of the 2020 ESFRI monitoring report, the EC High Level Expert Group report (2020) and the ERIC step 1 assessment (2021). Coordinated actions are dedicated to: (i) implement the E-RIHS governance structure and finalise its distributed architecture; (ii) support the E-RIHS management with strategies and related implementation plans regarding HR, procurement, risk management and quality system; (iii) maintain and build upon the established E-RIHS excellence in user access and foster FAIR open access with the design of the DIGILAB platform; (iv) strengthen international cooperation, cultivate synergies and consolidate the HS community around E-RIHS, while establishing E-RIHS in the landscape of EU RIs and global initiatives; (v) secure the ERIC sustainability and unlock its socioeconomic impact potential by providing E-RIHS with an updated business plan and a marketing strategy tailored for its new lifecycle phase.

Keywords: heritage science,research infrastructure
Quantum Engines in Ultracold Gases (QuantumEngine)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2499970.0
EU funding (EUR): 2499970.0
Participants: 1
Project status: SIGNED

Engines are ubiquitous: Heat engines have been and still are the driving force of modern life since the industrial revolution, and molecular motors power life on earth with astonishing efficiency. Current technological miniaturization is pushing engine design into areas where quantum properties need to be considered, which can drastically change the performance of engine-like processes. While initial mechanisms for motor operation have been demonstrated, the operation of autonomous quantum engines or extracting work from such a motor is elusive. QuantumEngine will combine novel concepts and innovative methods of ultracold atoms to develop autonomous quantum engines in the single-atom and many-body limits that provide cyclic motion or work. First, it will engineer energy conversion in such quantum systems at the level of single atoms and single energy quanta to increase efficiency and open the door to activate quantum matter. Second, it will unravel the effects of quantum properties on the operation of motors, including the long-standing question of quantum Brownian motion. Third, autonomous quantum engines in the single-atom and many-body regimes will be realized and characterized as novel leading-edge platforms for experimental quantum thermodynamics, shedding light on nonequilibrium hybrid many-body states of matter, light, and mechanics. Thus, the project will open up a unique opportunity to experimentally investigate fundamental and applied questions of quantum thermodynamics, such as efficiency and sustainability issues at the quantum level, with high relevance for emerging quantum technologies. Furthermore, it will enormously impact frontier areas of solid-state simulations, quantum physics, and active matter, potentially establishing new research fields.

Keywords: quantum engines,quantum thermodynamics,quantum technologies,many body quantum systems,quantum gases,single neutral atoms
An innovative human protein-based biomatrix for highly predictive preclinical drug evaluation, tissue engineering and personalized medicine (Human PREdict)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Portugal
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Despite extensive preclinical in vitro and animal screening tests, >90% of new drugs still fail in clinical trials. Key issues of lack of efficacy (40-60%) and toxicity (30%) in humans are still not sufficiently predicted in cell culture and non-human in vivo tests (animal models are just 50% accurate on average). The issue wastes years of development time and billions of Euros on unsuccessful therapies. The EMA and FDA recognise this problem and welcome novel technologies as alternatives to animal testing with more accurate predictive value to humans. However, a solution that meets industry needs does not currently exist. To meet this need, researchers and the pharmaceutical industry need an in vitro human tissue analogue that is (i) 3D, (ii) compositionally identical to human tissue, and (iii) has accurate physico-mechanical properties (stiffness, elasticity) that can be tuned to represent different tissue environments. Inability to mimic these environments leads to cellular behaviour not seen in vivo. Metatissue has the only biomatrix technology that meets all key user requirements. Derived from sustainable human platelet lysates, our technology ‘hPLMA’ can be used across 3D culture, bioink and organ-on-chip models. hPLMA most closely represents human tissue, through a 3D, human-derived, xeno-free biomatrix that can be tailored to represent any tissue physiology. It eliminates potential immune reactions to animal proteins and residual DNA/disease-causing prions and viruses. Researchers could significantly reduce use of animals in research and save billions in drug development costs with our practical and scalable solution. Our technology is patent protected, funded to TRL6 with the support of the ERC and Horizon 2020. This is a multibillion Euro market, with hPLMA revenues of €32 million forecast within 5 years of market entry. With EIC support we can complete our scale-up and extended user trials, and achieve full market readiness.

Keywords: autologous biomaterials,human platelet lysate,photosensitive biomaterials,tissue engineering,biological scaffolds,preclinical drug screening models,human 3d cell culture,human derived hydrogel
Cutting edge synthetic content recognizer, based on degenerative AI for image, audio and video media (IdentifAI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

The advent of AI has brought about revolutionary tools that are reshaping how we interact with technology and information. But as with most forms of rapidly evolving technology, it is increasingly harnessed by criminals for nefarious purposes. Generative AI (GenAI), which has immense positive potential, is being abused to create deepfakes. Deepfakes are non-consensual, highly realistic, AI-generated or altered images, videos or audio, which intend to be perceived as real but are actually fabricated. Deepfakes have proliferated into a myriad of industries including the financial sector, banking, media and healthcare. Advances in technology mean that deepfakes are becoming increasingly sophisticated and have been ranked as one of the most worrying uses of AI. The global cost of deepfakes fraud in 2024 exceeded €1T with half of all businesses having experienced fraud involving audio and video deepfakes. To combat this threat, we developed IdentifAI, a cutting edge, AI powered, technological platform capable of recognizing whether an image, video or audio is real or was produced using AI, across multiple domains with an accuracy of 96%. Our platform “unblurs” the lines between reality and fiction on AI products, giving users and businesses piece of mind, while providing safety and security against criminal intent. Utilising a unique “hacker perspective”, IdentifAI leverages “degenarative” models designed to detect AI-generated content across diverse media. Organizations are thus able to make informed and data-driven next steps in protecting their clients, assets, and reputations from complex deepfake attacks of today and tomorrow. IdentifAI is accessible via API can be deployed on-premise and on the cloud, providing results in near real time.

Keywords: degenerative ai,deepfakes,synthetic media authentication,deepfake detection platform,generative ai,api integration,bot function,cybersecurity,security operations centre
Biogeography and behavioral adaptations of late Quaternary hunter gatherers in the Sahara (BREATHE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Portugal,Italy
Call: ERA Fellowships (HORIZON-WIDERA-2023-TALENTS-02, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 2
Project status: SIGNED

Project BREATHE aims to contribute a new understanding of cultural and behavioral traits of North African early humans through the archaeological record of southern and northern Libya. This is a crucial region for understanding the trans-Saharan connections that contributed to the global dispersal of our species. However, the current scant archaeological and chronometric data for the Saharan and peri-Saharan regions limits our knowledge of biogeographic dynamics that linked different regions of North Africa at key moments of human biological and cultural evolution, especially around the emergence of H. sapiens ca. 300 ka. The project research areas, the Jebel Gharbi to the north and the Acacus and Messak to the south, represent the extremes of an ideal North-South transect with different environments and archaeological records, an important axis between sub-Saharan Africa and the Mediterranean. These arid regions have deeply eroded landscapes where Pleistocene geoarchaeological archives are rare. Except for few buried contexts, the evidence is mostly comprised of lithic artefacts found on open-air surfaces. Nevertheless, these surface lithics can provide a wealth of information when an array of cutting-edge analytical techniques (geospatial statistics, geometric morphometrics and wear analyses) are combined in the way proposed by BREATHE. These artefacts span the final phases of the Early Stone Age, the early emergence of the Middle Stone Age and its later manifestations, particularly the Aterian. The spatial amplitude of the research areas enables large-scale landscape analyses to be carried out, identifying land use and occupation patterns not detectable at a site-oriented research scale. This provides a unique window into past human behaviour and biogeographic dynamics in a central arid area that may have played a key role in the adaptive strategies that enabled our species to colonise new and challenging environments across Africa and beyond.

Keywords: pleistocene,early homo sapiens,north africa,sahara,middle stone age,lithic technology,morphometrics,taphonomy,landscape archaeology
From Injection to Ingestion: GRT AF Platform qualification for Oral Antibodies (I2I-GO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Biologics have revolutionised the treatment of chronic diseases such as diabetes and inflammatory bowel disease (IBD) due to their high selectivity and potent therapeutic responses. However, significant challenges persist. Biologics are currently limited to injectable delivery, resulting in systemic side effects, patient discomfort, and high costs that restrict accessibility, particularly in low-income regions. While oral delivery could significantly enhance patient compliance, current biologics degrade in the gastrointestinal (GI) tract, making this approach a longstanding challenge. Additionally, traditional biologic production in mammalian cells is expensive and labour-intensive, driving treatment costs to tens of thousands of euros per patient annually. To overcome these barriers, innovative production platforms are being explored to improve scalability and reduce costs, but these solutions often face issues of complexity and limited efficiency. GATBIO’s patented Green Recombinant Technology (GRT™) leverages Chlamydomonas microalgae as a scalable and cost-efficient platform for producing complex biologics. This innovative manufacturing process achieves high yields while dramatically reducing production costs compared to traditional mammalian and bacterial systems. Building on this technology, GATBIO has developed the GRT AF platform, which produces stabilised antibody fragments (AFs) tailored for oral delivery. These fragments are engineered with proprietary stabilisation motifs to withstand GI conditions, ensuring both therapeutic efficacy and structural stability. The AF platform is specifically targeting the rapidly growing IBD treatment market, which is valued at €27.3 billion in 2024 and is projected to reach €40.9 billion by 2032. Within this market, the Serviceable Available Market (SAM) for anti-TNF agents—aligned with GATBIO’s leading portfolio of candidates—is estimated at €10.5 billion by 2032.

Keywords: antibody fragment platform,platform scalability,oral biological drugs,recombinant proteins,genetic modification of microalgae,antibodies