Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
GEN IV Integrated Oxide fuels recycling strategies (GENIORS)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Nuclear safety
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Germany,Spain,Sweden,Belgium,Poland,France,France,France,Czechia,Czechia,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Investigating the safety of closed nuclear fuel cycle options and fuel developments (NFRP-2016-2017-1, 2016)
Start date: 2017-06-01
End date: 2021-05-31
Duration (months): 48.0
Total project cost (EUR): 7515950.34
EU funding (EUR): 4999699.96
Participants: 25
Project status: CLOSED

The current open nuclear fuel cycle uses only a few percent of the energy contained in uranium. This efficiency can be greatly improved through the recycling of spent fuel (as done today in France for instance), including, in the longer term, multi-recycling strategies to be deployed in fast reactors. In this context, GENIORS addresses research and innovation in fuel cycle chemistry and physics for the optimisation of fuel design in line with the strategic research and innovation agenda and deployment strategy of SNETP, notably of its ESNII component. GENIORS focuses on reprocessing and fuel manufacture of MOX fuel potentially containing minor actinides, which would be reference fuel for the ASTRID and ALFREDO demonstrators. More specifically, GENIORS will carry out research and innovation for developing compatible techniques for dissolution, reprocessing and manufacturing of innovative oxide fuels, potentially containing minor actinides, in a “fuel to fuel” approach taking into account safety issues under normal and mal-operation. It also considers the impacts of these strategies on the interim storage. For delivering a full picture of a MOX fuel cycle, GENIORS will work in close collaboration with the INSPYRE project on oxide fuels performance. By implementing a three step approach (reinforcement of the scientific knowledge => process development and testing => system studies, safety and integration), GENIORS will lead to the provision of more science-based strategies for nuclear fuel management in the EU. It will allow nuclear energy to contribute significantly to EU energy independence. In the longer term, it will facilitate the management of ultimate radioactive waste by reducing its volume and radio-toxicity. At the longer term, a better understanding of a spent nuclear properties and behavior, at each step of the cycle will increase the safety of installations for interim storage during normal operation but also hypothetical accident scenarios.

Keywords: gen iv fuels recycling
Fast Monte Carlo integration with repulsive processes (BLACKJACK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: France
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2026-01-31
Duration (months): 72.0
Total project cost (EUR): 1489000.0
EU funding (EUR): 1489000.0
Participants: 1
Project status: SIGNED

Expensive computer simulations have become routine in the experimental sciences. Astrophysicists design complex models of the evolution of galaxies, biologists develop intricate models of cells, ecologists model the dynamics of ecosystems at a world scale. A single evaluation of such complex models takes minutes or hours on today's hardware. On the other hand, fitting these models to data can require millions of serial evaluations. Monte Carlo methods, for example, are ubiquitous in statistical inference for scientific data, but they scale poorly with the number of model evaluations. Meanwhile, the use of parallel computing architectures for Monte Carlo is often limited to running independent copies of the same algorithm. Blackjack will provide Monte Carlo methods that unlock inference for expensive models in biology by directly addressing the slow rate of convergence and the parallelization of Monte Carlo methods. The key to take down the Monte Carlo rate is to introduce repulsiveness between the quadrature nodes. For instance, we recently proved that determinantal point processes, a prototypal repulsive distribution introduced in physics, improve the Monte Carlo convergence rate, just like electrons lead to low-variance estimation of volumes by efficiently filling a box. Such results lead to open computational and statistical challenges. We propose to solve these challenges, and make repulsive processes a novel tool for applied statisticians, signal processers, and machine learners. Still with repulsiveness as a hammer, we will design the first parallel Markov chain Monte Carlo algorithms that are qualitatively different from running independent copies of known algorithms, i.e., that explicitly improve the order of convergence of the single-machine algorithm. To this end, we will turn mathematical tools such as repulsive particle systems and non-colliding processes into computationally cheap, communication-efficient Monte Carlo schemes with fast convergence.

Keywords: monte carlo methods
Second Arctic Science Ministerial (ASM2)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Coordination and support actions
Countries involved: Germany
Call: Arctic Science Ministerial – Germany, October 2018 (H2020-IBA-SC5-ARCTIC-2017, 2017)
Start date: 2018-03-01
End date: 2019-06-30
Duration (months): 16.0
Total project cost (EUR): 300000.0
EU funding (EUR): 300000.0
Participants: 1
Project status: CLOSED

In response to the achievements of the US-administration under the first Arctic Science Ministerial (ASM1), the European Commission, the Republic of Finland and the Federal Republic of Germany agreed to co-host the second (ASM2) in the autumn of 2018. The Ministerial will not be an Arctic Council event, but connection is ensured by one of the organisers, Finland, holding the chairmanship of the Arctic Council between May 2017 and May 2019. The four themes discussed at the ASM1 and the relevant deliverables will be subjects of the Ministerial discussion in 2018 together with new themes that the organisers and the scientific community will identify as prominent. All the delegations present at the ASM1 will be invited along with other governments engaging in Arctic Science. The participation of indigenous communities from the Arctic region is considered a priority. Their traditional knowledge and understanding of their natural environment is an essential element which contributes significantly to scientific understanding. Representatives of different Arctic community organizations from various Arctic countries around the world will be invited to take part in the Ministerial. The ASM2 will take place over two days. On the first day, a Science Conference will showcase the latest achievements in relation with the deliverables agreed under the thematic areas defined by the Washington White House Conference in 2016. Scientific advances presented in the ASM1 deliverables, as well as a necessary future commitment, will be the core of the discussion, open to many different stakeholders, policy-makers, NGOs, media. These discussions will prepare the ground for the high-level segment that will take place the second day. The release of a Joint Statement will be one of the main objectives of the Ministerial meeting together with a report on the actions implemented in the previous two years and an updated list of deliverables that will generate results in the following years.

Keywords: arctic,climate change,sea ice,mosaic,traditional knowledge,indigenous communities
Understanding the evolution of regeneration-permissive gene expression and positional memory in Axolotl limb regeneration (RegGeneMems)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Austria
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2018-01-01
End date: 2023-10-31
Duration (months): 70.0
Total project cost (EUR): 2325659.0
EU funding (EUR): 2325659.0
Participants: 1
Project status: SIGNED

Molecular studies of development in diverse animal models have revealed the remarkably conserved set of morphogens governing growth and patterning of body axes and organ fields. Equally astounding is the diversity of form and function arising from the implementation of these morphogens. The systematic analysis of well-defined traits in closely related species has revealed how changes in gene regulatory sequences and their trans-acting factors have yielded diversity. An important future challenge is to understand, at the genome level, the evolution of animal form in situations where such a rich set of closely related species may not be available. Vertebrate limb regeneration is a particularly fascinating yet challenging context to pursue the evolution of traits related to controlling the body plan. Amputation of the Axolotl limb results in the formation of a limb blastema that morphologically and molecularly resembles the embryonic limb bud. In this system, the limb morphogen network must be reactivated only upon tissue removal and not wounding, but also corresponding to a positional memory existing in the adult tissue. These signalling cassettes must also be deployed in a way that can scale to the size of a blastema that is vast when compared to an embryonic limb bud. An important question is whether and how the limb development network has diverged to accomodate these unique traits. During Axolotl limb development and regeneration, some key limb morphogens display divergent expression patterns compared to other vertebrates. I hypothesize that this divergent expression has functional importance for allowing limb regeneration. My goal is to 1) understand how this divergent expression arose 2) functionally test its role in regeneration specificity and scaling, and 3) use the system to dissect the molecular nature of positional memory that is critical for regeneration. I refer to this work as “evo-reg”.

Keywords: limb bud development,fgf8,limb regeneration,limb evolution
Exoplanet atmospheres as indicators of life: From hot gas giants to Earth-like planets (EXOPLANETBIO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-11-30
Duration (months): 75.0
Total project cost (EUR): 2300962.0
EU funding (EUR): 2300962.0
Participants: 1
Project status: CLOSED

This is a proposal to use a new ground-breaking spectroscopic technique to study the atmospheres of extrasolar planets. Understanding planet atmospheric processes and their evolutionary histories is crucial for unambiguously identifying biomarker gases, and forms the main driver behind the enormous surge in exoplanet atmospheric research. I propose to lead a program using the new VLT CRIRES+ instrument, that will focus on the new ground-breaking developments in ground-based high-dispersion spectroscopy, in which my work plays a leading role. We successfully determined the dominant spectroscopically-active species in hot Jupiter atmospheres (e.g. Brogi, Snellen et al. Nature 2012), provided the first evidence for high altitude winds (Snellen et al. Nature 2010), and determined for the first time the spin-rotation rate of a young gas-giant planet (Snellen et al. Nature 2014) – pioneering a technique that combines high-dispersion spectroscopy with high-contrast imaging. The new CRIRES+ spectrograph at the VLT (2017) will have a revolutionary impact in the field, changing the main focus of current atmospheric research from hot 1000-1500 K gas giants to cooler 400-700 K Neptunes and Super-Earths. With this new instrument, I will 1) make a large inventory of planet spin rates as function of planet mass and age, 2) probe the atmospheres of cool super-Earths above the cloud-deck for the first time, solving for their bulk compositions. 3) determine the vertical and longitudinal atmospheric temperature profiles of hot Jupiters, and obtain a complete inventory of the C and O bearing molecules in their upper atmospheres. 4) I will for the first time probe isotope-ratios in exoplanet atmospheres. This project will be an important stepping stone in developing high-dispersion spectroscopic techniques for studying Earth-like exoplanets with the European Extremely Large Telescope.
Development of an innovative and cost-efficient process for friction and wear reduction (Triboconditioning)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-09-15
End date: 2020-11-14
Duration (months): 26.0
Total project cost (EUR): 2417872.5
EU funding (EUR): 1692510.75
Participants: 1
Project status: CLOSED

​Worldwide about 100 million terajoules, one fifth of the total energy produced, is used each year to overcome friction. The largest quantities of energy are used by industry (29%) and in transportation (27%). As much as 17.5% of the energy used in road transports can be reduced by effective implementation of new tribological solutions. This equals to annual energy savings of 11.6 exajoules, fuel savings of 330 billion litres and reductions in CO2 emissions by 860 million tonnes. Triboconditioning® is a cost- effective mechanochemical surface treatment that reduces friction and wear by up to 80% and 90% respectively. The genius of Triboconditioning is its simplicity, being easily implemented in standard CNC machines, combining both surface finishing and coating in one step. Triboconditioning is a flexible process that can be applied on both industrial and automotive components. More than 50 automotive components per vehicle can benefit from Triboconditioning including geared electric drive. Applied Nano Surfaces (ANS), is headquartered in Sweden with sales offices in Germany, Czech Republic and in North America. The company’s core competences lie in tribology, industrial engineering, product- and business development as well as marketing and sales. By today, ANS has grown to a strong position, working in over 70 ongoing customer programs with corporate giants in the automotive and general industry, both OEMs and Tier1s. Major global automotive firms (Tier 1s and OEMs) are already involved in the development of this technology. Several of them have manifested their interest in participating in the testing procedures of this project. With prototypes that completed technology verification in industrial conditions Technology Readiness Level lies at 7. We aim at piloting Triboconditioning® for final process optimization and industrialization to establish final license agreements and start having revenues by 2020. Results will be quickly transferred across sectors.

Keywords: friction,wear,surface,gears,automotive industry,nanocomposite,mechanochemical process,tribology,solid lubricant,motors,co2 emissions,fuel economy
PepZoSkin: Biocompatible Self-powered Electronic Skin (PepZoSkin)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-10-01
End date: 2021-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Electronic skin is seen as the next generation of wearable technology, ideally made of thin, self-powered, self-healing and flexible electronics able to mimic or augment natural skin functionalities. Smart prostheses to give amputees the sense of touch, completely biocompatible skin patches for wound care, or new on-skin drug delivery systems are only few e-skin applications that are being explored by the research community for the last several years. The main problems hindering the e-skin revolution are the lack of fully biocompatible piezoelectric materials, which are the basic component of any e-skin system, and the unavailability of adequate energy harvesting technology, which allows realizing an extremely compact and energy autonomous device. In the PepZoSkin project, we propose to develop an ultra-thin, flexible, self-powered e-skin device that combines innovative piezoelectric materials, microelectronics and sensors for wearable and implantable applications. In the frame of the main ERC Grant, we have synthesized radically new peptide-based materials with exceptional piezoelectric performance, unprecedented mechanical properties, and inherent biocompatibility, and used these materials as an active layer in basic sensing devices. In this PoC project, based on these promising results, we will further develop these basic devices to a TRL5 self-powered biocompatible core technology for an e-skin device. Our vision is to turn our core material into a key component of next generation compact and self-powered wearable and implantable systems, targeting biomedical applications as a market entry point. The e-skin market is expected to be worth more than 15 B$ by 2028. During this PoC project, together with medical, business and industrial stakeholders, we will focus on the validation of the technological and business feasibility of turning our e-skin prototype into a marketable competitive product, which will be developed and commercialized by a spin-off comp

Keywords: peptides,self assembly,piezoelectricity,biocompatible,energy harvesting,self powered,electronic skin,bio nanotechnology,healthcare
Gasdermin D is a novel effector in the extrinsic apoptosis pathway (Inflapoptosis)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Pyroptosis is a highly inflammatory form of cell death that drives host protection against intracellular pathogens. Pyroptosis is initiated by inflammasome-activated inflammatory caspases (e.g., caspase-1/4/5/11), which cleave gasdermin D to trigger plasma membrane pores. In contrast, apoptosis is driven by apoptotic caspases (e.g. caspase-3/7/8/9), and is traditionally classified as an immunologically silent form of cell death that is important for development and maintenance of homeostasis. However, emerging studies suggest that caspase-8 activation during extrinsic apoptosis promotes inflammation by triggering the assembly of a proinflammatory, multi-protein complex called the NLRP3 inflammasome, through an ill-defined mechanism. A recent study identified a caspase-3 cleavage site within gasdermin D; cleavage of gasdermin D by apoptotic caspase-3 suppresses the cytotoxic function of this protein. These suggest a complex crosstalk between the pyroptosis and apoptosis. Therefore, the aim of this project is to investigate 1) novel proinflammatory functions of gasdermin D during extrinsic apoptosis; 2) the role of gasdermin D in caspase-8-dependent NLRP3 activation; and 3) the importance of caspase-3-mediated gasdermin D inactivation at steady state in vivo and during chemotherapy. This project will greatly enhance the skills and competence of the experienced researcher through advanced training and international mobility, and is in line with Horizon 2020 Work Programme objective.

Keywords: cell death,inflammasome,gasdermin d,apoptosis,caspase 8,smac mimetic
Scattering Amplitudes for Higgs Production at High-Order as touchstone for Automated Multiloop Feynman Calculus (HiProLoop)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Scattering Amplitudes sit at the core of quantum field theory. On the one side, they capture the high energy regimes of fundamental interactions among elementary particles, hence, their accurate determination is a crucial test for the predictive power of the theoretical frameworks Particle Physics is based on. On the other side, scattering amplitudes are the tiniest mathematical lab of the Universe, where more formal investigations about the symmetries ruling particle interactions can be performed. New relations and dualities involving scattering amplitudes may become manifest only through their actual calculations at higher orders in perturbation theory, yet invisible to the canonical approach to quantum field theory. Therefore, progress in the ability of computing scattering amplitudes at very high accuracy is crucial for understanding the fundamental interactions and for providing accurate predictions within phenomenological analyses. HiProLoop aims at providing the most accurate determination of the virtual contributions to amplitudes relevant for Higgs phenomenology, by considering 1) the associated production of a Higgs boson and a jet at 2-loop, 2) the Higgs boson production in gluon fusion at 3-loop, as well as 3) the photon-pair production in association with a jet at 2-loop. The latter process is an important background to the process-1, and it can also be considered as a touchstone for the automation of generic 2-loop scattering amplitudes at high multiplicity. This effort should culminate in the development of a solid framework for the evaluation of generic 2-loop scattering amplitudes, which represent a currently open, urgent problem. Therefore the results of HiProLoop will become milestones for the theoretical physics community. HiProLoop will exploit mutual exchange of competences and tools between Theoretical Physics, Algebraic Geometry, Number Theory and Computer Science. The dissemination of the results will follow an ambitious communication plan.

Keywords: scattering amplitudes,standard model calculations,feynman integrals