Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Recycling of hard-to-treat, post-consumer textile wastes and conversion to insulation material for construction industry using a novel conversion technology. (Insuwaste)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: United Kingdom
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2014-11-01
End date: 2015-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

This project, is relevent to call topic SC5-20-2014-1, is designed to scale up, develop and commercialise a manufacturing process for converting currently unusable post-consumer contaminated fibre waste from carpets and mattresses to a value added thermal and/or acoustic insulation for use in the building & construction industry. The project develops a novel insulation panel or roll with the effective design and development of a manufacturing system to collect and reprocess with novel anti-bacterial treatments to produce a competitive product that can be systemised at the commercial scale. A successful proof of principle trial and sample material has been produced. A detailed techno-economic feasibility study and experimental work is required for the improvement of the thermal performance and neutralisation of the bacterial contamination in the recycled fibre waste from carpets and mattresses. In addition, the production line requires machinery for cutting, tearing, cleaning, anti-bacterial contamination processing and packaging at the manufacturing level. EC support is the catalyst needed to drive this innovation into the market, while the exposure the scheme brings will help us to penetrate the market more quickly and exploit this technology in the UK, and will exploit within Europe and/or licence to others. The likely benefits to the partners, endusers and society are the access to valuable textile fibre, a significant reduction of carbon emissions and fostering business models that bring fibre waste close to zero and build a better understanding of the environmental impact of carpet waste fibre, as well as to mitigate the dependency of Europe on imported raw textiles.

Keywords: carpet mattress waste recycling insulation anti bacterial construction
ERA-NET to support the Joint Programming in Neurodegenerative Diseases strategic plan (JPND) (JPCOFUND2)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: ERA-NET Cofund
Partnership: JPCOFUND2 (ERA-NET)
Countries involved: Austria,Italy,Ireland,Italy,Israel,Germany,Spain,Norway,Finland,Hungary,Poland,Slovenia,Sweden,Switzerland,Türkiye,Belgium,Latvia,France,Czechia,Netherlands,Denmark,Luxembourg,Portugal,Portugal,Canada,United Kingdom
Call: ERA-NET to support the Joint Programming in Neurodegenerative Diseases strategic plan (JPND) (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 33438899.0
EU funding (EUR): 11010911.34
Participants: 33
Project status: SIGNED

Worldwide, nearly 47 million people are currently estimated to be living with dementia, and the number is expected to almost double every 20 years, yet treatments that prevent or stop the progression of neurodegeneration are still lacking. Tackling this grand challenge requires enhanced coordination of national efforts to accelerate discovery. Such synergies have been created among 30 countries in the pilot EU JPI on Neurodegenerative Disease Research (JPND). JPND has a long standing experience in collaborative actions; since 2011, a cumulated funding of 132M€ has been dedicated to competitive transnational calls and JPND is now a reference for European and global knowledge and as an innovation platform in the area of neurodegenerative diseases. Building on earlier successes of the JPND Research Strategy in scaling-up and establishing synergies with Horizon 2020, there is a need to continue previous efforts to consolidate the JPND successes in defragmentation, better coordination and alignment amongst the countries, by developing new links with the EC. JPcofuND 2 aims at launching in 2019 an ambitious call for proposals on personalised medicine, where the benefits for the patients affected with neurodegenerative diseases will be explored through personalised diagnosis, personalised prevention and personalised care. Participating countries have earmarked 24,7 M€ of national funds for this call. Moreover, to expand the impact of the project, JPND will continue to implement other actions without EU co-funding such as aligning national research strategies, making databases more accessible and interoperable, developing enabling capacities such as supportive infrastructure and platforms, capacity building, education and training. These actions are required in parallel to achieve the highest impact for the patients, their carers and for society as whole and address this grand challenge in the coming years.

Keywords: neurodegenerative diseases,grand challenge,national research plan alignment,transnational,research programs,personalised diagnosis,personalised prevention,personalised care,enabling activities
The Effects of Air Pollution and Physical Activity on Respiratory Health in Children in the Context of Urbanization (APPARHU)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-02-01
End date: 2022-01-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Urbanization has changed the land-use in Europe and the majority of the world. Over 80% of Europeans, who are expected to live in urban neighbourhoods by 2030, are at risk of developing chronic respiratory disease (CRD) due to the chronic exposure to increased levels of air pollution, that is characteristic for urban and peri-urban areas. Increased car traffic due to high population and building densities in cities have been associated with poor air quality. Research on how the continued urbanization and the built environment affect human health is emerging. To date, very little is known about how the built environment affects respiratory health in children directly, or indirectly by influencing health behaviours such as physical activity. Childhood is a period of growth and development, which makes children particularly vulnerable to changing environments. Because the respiratory system and the lungs act as the first organ of contact with air pollutants, the health effects of air pollution exposure need to be studied in combination with physical activity. Physical activity increases the breathing rate and the depth of breaths taken in, which facilitates pollutants to reach areas deep in the bronchial tree at higher concentrations, where they can cause damage locally, or be absorbed into the blood stream, and impact regulatory processes systemically. The purpose of this project is to analyze how the built environment affects the combined exposure to air pollution and physical activity with respect to children's respiratory health pre- and postnatally using an exposome approach. We will use data from the Human Early-Life Exposure (HELIX) project, including 1301 mother-child pairs from 6 longitudinal cohort studies across Europe. This research is important, because we will use original, innovative, and interdisciplinary methods to assess how the built environment affects respiratory health in early life, the optimal time point to prevent CRD.

Keywords: exposome,determinants of paediatric lung health pre and postnatally,built environment,physical activity,air pollution,omics profiling,gis modelling
An end-to-end system for the production and delivery of photorealistic social immersive virtual reality experiences (VRTogether)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Spain,Spain,Spain,Switzerland,Greece,France,France,Netherlands,Netherlands
Call: Media and content convergence (H2020-ICT-2016-2, 2016)
Start date: 2017-10-01
End date: 2020-12-31
Duration (months): 39.0
Total project cost (EUR): 4436493.64
EU funding (EUR): 3929937.5
Participants: 11
Project status: CLOSED

VR-Together will offer new ground-breaking virtual reality experiences based on social photorealistic immersive content. For this purpose, it will develop and assemble an end-to-end pipeline integrating state-of-the-art technologies and off-the-shelf components. The challenge of VR-Together is to create photorealistic truly social virtual reality experiences in a cost-effective manner. Immersive media production and delivery through innovative capture, encoding, delivery and rendering technologies. The project will demonstrate the scalability of its approach for production and delivery of immersive content across 3 pilots. It will introduce new methods for social VR evaluation and quantitative platform benchmarking for both live and interactive content production, thus providing production and delivery solutions with significant commercial value.

Keywords: virtual reality,immersive virtual environaments,social interaction,distributed rendering,point clouds
ORTHOpedic randomized clinical trial with expanded bone marrow MSC and bioceramics versus autograft in long bone nonUNIONs (ORTHOUNION)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Germany,Germany,Italy,Italy,Spain,France,France,France,France
Call: Clinical research on regenerative medicine (H2020-SC1-2016-RTD, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 5999150.87
EU funding (EUR): 5999150.87
Participants: 17
Project status: CLOSED

Current orthopaedic treatments permit spontaneous bone regeneration to unite and heal 90% bone injuries. Non-union associates pain and disability, often requiring biological enhancement. Regenerative medicine research suggests to the general public that alternative treatments based on advanced therapy medicinal products (ATMP) are already available. However, early clinical trials only explore its potential benefit. Underreported results and absence of early trial confirmation in adequately powered prospective randomized clinical trials (RCT) indicate that evidence is not available to transfer any technique into routine clinical application. This ORTHOUNION Project was developed from FP7-Project (REBORNE). Its results confirmed 92% bone healing rate (Gómez-Barrena et al, 2016 submitted manuscript) with an autologous ATMP of GMP expanded bone marrow derived human MSC in non-unions, where the reported bone healing rate after surgery with standard bone autograft is 74%. Any further development requires adequately powered prospective RCTs. This will be the main aim of ORTHOUNION: to assess clinically relevant efficacy of an autologous ATMP with GMP multicentric production in a well-designed, randomized, controlled, three-arm clinical trial under GCP, versus bone autograft, gold-standard in fracture non-unions. A non-inferiority analysis will evaluate if cell dose can be lowered. ATMP has been authorized by the National Competent Authorities of the participating countries in 3 previous trials (REBORNE) and will be monitored by ECRIN-ERIC to ensure quality and credibility of RCT results. Secondary aims include innovative strategies to increase manufacturing capacity and lower costs to pave translation into routine clinical treatments, biomaterial refinement to facilitate surgery, personalized medicine supportive instruments for patient selection and monitoring, and health economic evaluation. Results in this project may help define the future of bone regenerative medicin

Keywords: bone regeneration,expanded bone marrow derived mscs,regulatory approved imp,long bone fracture non union,avascular necrosis of the femoral head,multicentric comparative clinical trials
Building-up Centre of Excellence for advanced materials application (CEMEA)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Framework Partnership Agreement
Countries involved: Finland,Slovakia
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-05-12
End date: 2020-05-11
Duration (months): 60.0
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 11
Project status: CLOSED

CEMEA project´s main objective in the long run is to establish a joint Centre of Excellence for advanced materials application (CEMEA) based on long-term strategic cooperation between VTT Technical Research Centre of Finland and University of Helsinki (Finland) on the one hand and Slovak Academy of Sciences (Slovak) on the other. The rationale behind this project is to ensure sustainable financing and quality of research in the field of advanced materials in Slovakia as one of Key Enabling Technologies (KETs). Our goal is to bring and nurture the culture of excellence in Slovakia and to leverage support under HORIZON 2020 and other available funding opportunities. CEMEA project aligns with Smart Specialization Strategy of the Slovak Republic by focusing on areas of specialisation based on best available scientific and research capacities (identified in RIS3) – in particular on research of advanced materials and nanotechnology, biomedicine, biotechnology and sustainable energy as application areas for advanced materials. Results of the new CEMEA Centre´s research will be applicable in areas of economic specialisation identified in RIS3 of the Slovak Republic. Projects long-term goals include: - Become a leading research organization in advanced materials research in Europe with management based solely on principle of excellence - Nurture “culture of excellence” in Slovakia and thus, increase the human potential of the Centre, ensure spreading of excellence and circulation of knowledge in local economy (in Slovakia) - Develop and strengthen international cooperation with Centres of excellence or other excellent organizations in Europe - Improve ranking in selected composite indicators of research excellence (measurable and significant improvement in research and innovation culture)

Keywords: centre of excellence,advanced materials,nanotechnologies,biotechnologies,culture of excellence,research and innovation,education
Soil Care for profitable and sustainable crop production in Europe (SOILCARE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Ireland,Italy,Switzerland,Belgium,Greece,Hungary,Hungary,Sweden,Norway,Belgium,Poland,Romania,France,Czechia,Netherlands,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom,Portugal,United Kingdom,United Kingdom
Call: Assessing soil-improving cropping systems (H2020-SFS-2015-2, 2015)
Start date: 2016-03-01
End date: 2021-08-31
Duration (months): 66.0
Total project cost (EUR): 7628403.0
EU funding (EUR): 6999993.0
Participants: 33
Project status: CLOSED

European crop production is to remain competitive while reducing environmental impacts, requiring development and uptake of effective soil improving cropping systems. The overall aim of SOILCARE is to identify and evaluate promising soil-improving cropping systems and agronomic techniques increasing profitability and sustainability across scales in Europe. A trans-disciplinary approach will be used to evaluate benefits and drawbacks of a new generation of soil improving cropping systems, incorporating all relevant bio-physical, socio-economic and political aspects. Existing information from literature and long term experiments will be analysed to develop a comprehensive methodology for assessing performance of cropping systems at multiple levels. A multi-actor approach will be used to select promising soil-improving cropping systems for scientific evaluation in 16 study sites across Europe covering different pedo-climatic and socio-economic conditions. Implemented cropping systems will be monitored with stakeholder involvement, and will be assessed jointly with scientists. Specific attention will be paid to adoption of soil-improving cropping systems and agronomic techniques within and beyond the study sites. Results from study sites will be up-scaled to the European level to draw general lessons about applicability potentials of soil-improving cropping systems and related profitability and sustainability impacts, including assessing barriers for adoption at that scale. An interactive tool will be developed for end-users to identify and prioritize suitable soil-improving cropping systems anywhere in Europe. Current policies and incentives will be assessed and targeted policy recommendations will be provided. SOILCARE will take an active dissemination approach to achieve impact from local to European level, addressing multiple audiences, to enhance crop production in Europe to remain competitive and sustainable through dedicated soil care.

Keywords: soil quality,crop production,environmental impacts,sustainability,profitability,socio economic factors
Gut microbiota impact on brain development and plasticity. (GaMePLAY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The gut microbiota is characterized by a variety of microorganisms that live in symbiosis with our body and that play a key role in host immune system development and metabolism. Studies in adult germ-free mice suggested the influence of gut commensals on emotional behaviors and stress responses. However, the exact mechanism through which these bacteria affect brain function is largely undiscovered and, their impact on brain development is still a relatively unexplored territory. In my project I propose to investigate how the gut microbiota modulates brain development and plasticity using the established model of mouse developing visual cortex. To find if development and environmental stimuli affect intestinal bacteria, the gut microbiome of mice reared in standard condition (ST) or in an enriched environment (EE) that is known to modulate visual development, will be analyzed at different ages: before weaning (P15), after weaning (P28) and in adulthood (P60) providing for the first time a developmental timeline of the gut microbiota in mice. Then, I will perturb the microbiota composition through antibiotic treatment (ABX) or fecal transplantation (FT) in ST and EE mice, and assess visual cortical function maturation and ocular dominance plasticity. Dendritic spine dynamics analyzed by in vivo two-photon imaging and formation of inhibitory and excitatory neurons will be assessed in the primary visual cortex (V1) as morphological biomarkers of visual cortical development. Finally, in order to find the molecular mechanisms and mediators of gut commensals effect on neuronal circuits, I will perform a transcriptome analysis in V1 of ST and EE mice treated with ABX, or subjected to FT. My research will bring a substantial advancement in the field, revealing how the early interaction between microbiome and host can shape cortical functions, hopefully enabling the discovery of biomarkers for facing neurodevelopmental and psychiatric diseases.

Keywords: postnatal neurodevelopment,visual cortex,critical period,ocular dominance,plasticity,gut microbiota,environmental enrichment
CARR·e: Lightweight and versatile electric vehicle applied to urban logistics (Carr-e)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Austria
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-03-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Spirit Design has designed Carr.e, an innovative urban vehicle that exploit the technical components of e-bikes and applies them to a 4wheeler cargo so to exploit a 125,25M€ (by 2020) business opportunity. We are an internationally leading strategic design company born in 1993 in Vienna. European cities are expected to reach 75% of the total population by 2020, besides Urban Freight Transport (UFT) represents 8% to 15% of the total. Urgent is the need of countermeasures to avoid road congestions, lower environmental pollution, from greenhouse gases (25% due to transport) to noise. Besides, e-commerce heavily relies on UFT and B2C sales are growing at a rate of 14% per year, urban logistics need to find solutions that are cost-effective, productive, efficient and environmentally sustainable. Consequently, we propose Carr·e, which exploits electric power-assisted cycles features to create a 4-wheeler, innovative pedelec (pedal electric cycle) designed for UFT that needs no driving license and no homologation. Carr.e includes a modular architecture to provide flexible driver protection in a highly space-saving way. Carr.e is designed so that batteries can be easily changed and not recharged. Carr.e is supported by the interest of main UFT stakeholders: POST AG, ÖAMTC and REWE and will be manufactured by the KSR Group. Carr·e will accumulate by 2020 a turnover of 125,25M€ and 32 new employees, ROI of 4,71%. Carr·e contributes to the EC goal for UFT of "CO2-free city logistics in urban centres by 2030". Carr·e has been designed to address UFT issues: •Reduction of urban environmental pollution. •Increase of the cargo companies' delivery efficiency. •An extension of B2B market applications for public administrations, SME business and corporations, tourism agencies or large-sized recreational areas thanks to its modularity. •Energy efficient and low-cost solution for a wider range of cargo. •No need to spend time to recharge batteries.

Keywords: electric vehicles,urban freight transportation,environment,sustainability,urban areas,smart cities