Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrated AI-Driven Systems For Kidney Transplant Precision Medicine (AI-Care) (AI CARE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-07-01
End date: 2029-06-30
Duration (months): 60.0
Total project cost (EUR): 1997935.0
EU funding (EUR): 1997935.0
Participants: 2
Project status: SIGNED

Despite considerable improvements in short-term allograft and patient survival in kidney transplantation in the past two decades, long-term graft survival remains low, with 20% of transplants failing within five years. Rejection remains a leading cause of graft loss, with immediate consequences for patient morbidity and mortality, posing a major burden on healthcare systems. Increased allograft longevity requires improved patient monitoring and rejection risk stratification using mechanistically informed, non-invasive biomarker strategies and precision diagnostics. The main limitation for such an endeavor is the lack of deeply phenotyped cohorts. Given the complexity and heterogeneity of allograft rejection, patient cohorts with sufficient volume, velocity, variety and validity of data are critical in order to capture disease activity, disease stage, improve risk stratification and optimize treatment. Another limitation is the paucity of multidimensional and integrative research strategies. The goal of the ERC AI-Care project is therefore to go beyond the current state of the art by establishing a transplant precision medicine system to 1) facilitate personalized, non-invasive patient monitoring using cell-free DNA technology (Liquid biopsy) 2) improve rejection diagnosis beyond conventional histology using molecular technologies and digital pathology, and 3) gain further mechanistic insights and improve diagnostic accuracy of transplant organ diseases and apply this knowledge to new research areas.
Photochemical organocatalytic atropselective processes for the sustainable synthesis of biorelevant axially chiral molecules (PHOTO-ATROP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 186720.08
EU funding (EUR): 186720.08
Participants: 2
Project status: CLOSED

Chiral molecules containing axes of chirality (known as atropisomers) are present in natural products, bioactive molecules, and functional materials. Their increasingly important role in pharmaceuticals means that effective asymmetric strategies are needed for their preparation. However, the available catalytic methods rely on ionic pathways, which limits the diversity of atropisomers that can be achieved. This project seeks to close this gap in asymmetric methodology by providing new catalytic techniques for atropselective synthesis, based on radical chemistry, to greatly boost the impact of axially chiral compounds in drug discovery. We aim to develop methods that combine enantioselective organocatalysis with visible light photochemistry, two powerful strategies with extraordinary potential for the sustainable preparation of chiral molecules. Achieving this target would also address the key synthetic challenge of developing light-driven atropselective processes proceeding via radical pathways. The research will combine the host’s expertise in photochemistry and radical reactions with the applicant’s background in asymmetric organocatalysis. The resulting strategies will be used as a platform for assembling libraries of atropisomeric compounds that, together with biological screening carried out in collaboration with the pharmaceutical company Bayer AG, will increase the probability of success in identifying drug-candidate structures. The PHOTO-ATROP project is unique because it provides training in “organocatalysis” and “photochemistry applied to drug discovery”, thus contributing to European excellence and sustainability. Its multicultural nature will broaden the fellow’s competencies and place him in a competitive position for his next career move

Keywords: asymmetric organocatalysis atropselectivity radical chemistry photochemistry axially chiral biaryls enantioselective catalysis
INNOVATIVE TOOLS TO CONTROL ORGANIC MATTER AND DISINFECTION BYPRODUCTS IN DRINKING WATER (intoDBP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Spain,Cyprus,Italy,Belgium,Austria,United States,Australia,Ireland,Germany
Call: Securing drinking water quality by protecting water sources against pollution, providing innovative monitoring and treatment solutions and ensuring safe distribution (HORIZON-CL6-2022-ZEROPOLLUTION-01, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 3994707.25
EU funding (EUR): 3994707.0
Participants: 20
Project status: SIGNED

intoDBP will create innovative tools and strategies to improve water quality management for safe human use and a healthy environment. It focuses on catchment protection and forecasting, transformative drinking water treatment, and real-time monitoring to combat the effects of climate and global change. In particular, intoDBP focuses on pollution and risks related to disinfection by-products (DBPs). By developing and applying advanced, integrated, and cost-effective sensors and analytical methods, intoDBP will expand knowledge on water quality and DBP precursors to better understand its formation and human exposure in Europe. intoDBP monitoring results will feed into numerical forecasting tools to predict source water changes and formulate climate change adaptation pathways at catchment and treatment scale. intoDBP also develops transformative options for advanced and cost-effective upgrade of water treatment and disinfection. In the intoDBP consortium researchers, small and large enterprises, communication experts and public services join forces to generate interdisciplinary solutions, that will generate a renewed perspective of drinking water surveillance, support decision-making and governance, and increase system resilience. intoDBP will implement and validate its cross-cutting products in four complementary case studies from three European countries where compliance with DBP regulation currently is an acknowledged challenge. The direct and visible positive impact of intoDBP in the case studies will foster rapid product adoption at a European and global scale, thus strengthening Europe’s position and role in the global water market. Reaching out beyond the water sector itself, intoDBP will directly engage society through surveys to analyse exposure to DBPs, collect data about catchment protection initiatives, create awareness and promote sustainable consumer behaviour such as reducing bottled water consumption.

Keywords: drinking water treatment,water technology,water climate interactions,non target analysis,exposure,sensors,bioreporters,fingerprinting,transformative treatment,organic matter,forecasting
Biophysical investigation of the liquid-liquid phase separation solvent interface. (BiophInLLPSInt)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 3
Project status: CLOSED

Liquid-liquid phase separation (LLPS) is central to compartmentalisation of biochemical processes and allows co-localisation of a whole biological machine and its substrates at high local concentrations. This often dynamic and reversible assembly is formed by multivalent interactions between several biomolecules, and some instances involve low complexity sequences that have been linked to amyloid fibre formation. While the biophysical understanding of this phenomenon has recently been of high interest in the scientific community, the interactions of LLPS-forming proteins from the dilute phase with the interface to the condensed phase remain elusive. In this project we aim to dissect these transient interactions using state-of-the-art biophysical techniques. More specifically, we will use nuclear magnetic resonance (NMR), high-resolution-relaxometry (HRR) and an array of single-molecule fluorescence techniques to dissect up to atomic resolution and at multiple time-scales the transient interactions of the dilute phase proteins with the interface of the condensed state. We shall rely on the non-homologous end joining (NHEJ) system, that our laboratory has recently shown to exhibit LLPS in a broad range of conditions. Atomic-level dynamic information on the mechanisms for NHEJ phase separation and assembly could prove crucial both in the fundamental understanding of LLPS formation and growth, and in rational drug design aimed at preventing double-strand break repair by NHEJ in the frame of cancer treatment.

Keywords: liquid liquid phase separation,high resolution relaxometry,nmr,smfret,nhej,transient interactions
The Influence of Gut Microbiota and Microbial Metabolites on a Mouse Model relevant to Binge Eating Disorder (MicroBED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Israel
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 200538.24
EU funding (EUR): 200538.24
Participants: 1
Project status: SIGNED

Binge Eating Disorder (BED) is a psychiatric disorder with grave health risks. Previous studies have associated alterations of gut microbiota status with BED. However, whether this is a causal relationship, where differences in gut microbiota status promote binge-like eating behavior independent of changes in body weight remains to be explored and forms the central aim of MicroBED. MicroBED will also characterize the influence of gut microbiota on behavioral outcomes relevant to BED via the hedonic feeding circuit. Lastly, MicroBED will explore whether certain microbial metabolites can alleviate binge-like eating behavior. It hypothesizes that gut microbiota influences BED associated behavior by altering activation of the hedonic feeding circuit, via circulating microbial metabolites. MicroBED will be performed in the Weizmann Institute, one of the world’s leading multidisciplinary basic research institutions. It will be highly interdisciplinary and involve collaboration with renowned neuroscientists and computational biologists. The outcomes of MicroBED could have significant societal impact as it can lead to development of novel therapies for BED. General public, policy makers and scientific audiences will be informed about the outcomes of MicroBED through a multi-pronged dissemination strategy. MicroBED will also greatly aid my career development by providing world-class training in a multidisciplinary setting. It will enhance my research skills, foster my managerial abilities, and strengthen my professional network. I will also benefit from the high-level training provided by the Feinberg Graduate School, including courses and workshops in technical and soft skills, and by attending international conferences like FENS and SfN. To conclude, MicroBED will provide an important opportunity in my career, that would allow me to acquire critical skills and competencies, that will enable me to transition from an early career scientist to research group leader.

Keywords: host microbiome interaction
Uncovering the inner workings of galaxies at cosmic noon (GALPHYS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1945250.0
EU funding (EUR): 1945250.0
Participants: 1
Project status: SIGNED

Lookback studies have assembled a fairly complete census of galaxies over 85% of cosmic time and established that the bulk of stars, which today reside in massive ellipticals and spirals, formed rapidly at redshift z~1–3. Most of this star formation took place in massive gas-rich, turbulent disks, which already followed tight scaling relations in their global properties, and in which dense bulges, fast growing central black holes, and galactic winds were ubiquitous. The next frontier is to uncover the physical mechanisms inside galaxies that govern the buildup of stars and the emergence of galactic structure. This goal can only be reached by resolving gas motions and distributions on the Toomre scale of ~1 kpc at z>1, requiring ~25 times sharper views than typically achieved so far. Revolutionary improvements in observing sensitivity and resolution now make this possible: the advent in 2022 of the most advanced near-IR adaptive optics-assisted integral field spectrograph ERIS at the Very Large Telescope. GALPHYS centers on an ambitious 900-hour ERIS Guaranteed Time program led by the applicant, and exploits key synergies with cutting-edge (sub-)millimeter interferometry at IRAM/NOEMA and ALMA of which the applicant is a core member of Guaranteed and Open Time programs. The requested 3 postdoc and 2 PhD positions are required for the PI to establish a research group to execute the program. GALPHYS will produce breakthroughs in the most important, outstanding issues in galaxy evolution: (1) mass and angular momentum transport, (2) the origin of gas turbulence, (3) the evolution of giant star-forming complexes, and (4) the physics of outflows powered by stellar and AGN feedback. GALPHYS will provide excellent training for junior scientists and an unmatched benchmark of lasting legacy in galaxy evolution.

Keywords: galaxy evolution,galaxy kinematics,galaxy structure,high redshift galaxies
Quantum Internet Alliance - Phase1 (QIA-Phase1)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Cluster 4 other
Destination: Other Digital, Industry and Space destinations
Action type: Research and Innovation actions
Countries involved: Netherlands,Austria,France,Spain,Denmark,Germany,Italy,Luxembourg,Portugal
Call: HORIZON-CL4-QUANTUM-03-SGA - Building the Quantum Internet (SGA) (HORIZON-CL4-2022-QUANTUM-03-SGA, 2022)
Start date: 2022-10-01
End date: 2026-03-31
Duration (months): 42.0
Total project cost (EUR): 24000000.0
EU funding (EUR): 24000000.0
Participants: 30
Project status: SIGNED

The mission of the Quantum Internet Alliance (QIA) is to build a global Quantum Internet made in Europe – by developing a full-stack prototype network, and by driving an innovative European Quantum Internet ecosystem capable of scaling the network to worldleading European technology. Building on its proven track record in teamwork, which has already resulted in world first Quantum Internet technology, QIA advances this mission in two complementary objectives: The first is the realization of a full-stack prototype network able to distribute entanglement between two metropolitan-scale networks via a long-distance backbone (>500 km) using quantum repeaters. The second is the establishment of a European platform for Quantum Internet development, which will act as a catalyst for a European Quantum Internet Ecosystem including actors all along the value chain. QIA’s network will enable advanced quantum-network applications and prepare the ground for secure quantum computing in the cloud, thanks to our new generation of end nodes including both processing nodes and low-cost photonic client devices. Nodes in the metropolitan network will be interconnected via hubs that allow the scalable connection of hundreds of end nodes, paving the way for early adopters. The long-distance backbone will be realized using fully functional quantum repeaters unlocking Pan-European end-to-end quantum communication. QIA’s prototype network will operate on standard optical fibers and serves to validate all key sub-systems, ready to be scaled by European industry. In this first SGA we will advance towards the long-term objectives set up in the FPA project. Here we present in detail how work will be implemented during this first phase of the SGA.

Keywords: quantum networks,quantum processing nodes,quantum repeaters,quantum internet,quantum network stack,quantum software stack
Health/well being, Global changes, and Sustainable transitions in University of Toulouse (AToUT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: France,Poland,South Africa,Portugal,Belgium,Croatia,Kenya,Mexico,Canada,Italy,Brazil,Algeria,Germany,Ecuador
Call: MSCA COFUND 2024 (HORIZON-MSCA-2024-COFUND-01, 2024)
Start date: 2025-11-03
End date: 2030-11-02
Duration (months): 60.0
Total project cost (EUR): 4963200.0
EU funding (EUR): 4963200.0
Participants: 24
Project status: SIGNED

AToUT is the French word for advantage, asset, benefit like a trump card. AToUT offers to host 50 post-doctoral fellows in University of Toulouse (UT), in 3 scientific areas that are i) Understanding and promoting good health and well-being ii) Understanding global changes and their impact on societies iii) Accelerating sustainable transitions: mobility, energy, resources and industrial change. By addressing these societal issues, Post-Docs will enhance their ability to connect with the public sphere, fortify the link between research and society, and augment both their scientific and technical competencies, as well as their societal intelligence, a pivotal element in their career development and employability. We will welcome 50 researchers from around the world, each for a period of 2 years, transparently selected for their academic excellence, to address the strategic applied and scientific axes of the programme. The beneficiaries will be free to develop their own research project, they will receive support, supervision and mentoring by their host team and laboratories. Fellows will have access to a structured training programme to develop their scientific, professional, personal and soft skills. They will benefit from the international academic and business network of AToUT'S associated partners (5 competitiveness clusters and 16 international universities), set up to establish collaborations and prepare their future careers in one or other sectors. Fellows will be required to engage in open science, public outreach events. AToUT will last 60 months (3 November 2025 to 2 November 2030). Its implementation is based on a governance structure organised around the services of the University of Toulouse including a human resources department, a department of valorization and business relations, an open science task force and an ethics committee, a partnership with Toulouse Tech Transfer for intellectual property management, and services for hosting foreign researchers.

Keywords: postdoc,health and well being,global changes,sustainable transitions,
Textile-based Metamaterials for Broadband Noise Absorption in Low-frequency Range (TextMetamater)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

Owing to rapid urbanization, millions of people are suffering noise, especially the noise in a low-frequency regime (<500 Hz). Conventional acoustic absorbers (e.g., glass fiber and polyester fiber) have been applied to control the noise by absorbing incident acoustic energy. While the sound absorption in the low-frequency regime using such absorbers is impractical because their dimensions are usually comparable to the large wavelengths of low-frequency sound waves. In recent years, acoustic metamaterials have exhibited excellent low-frequency sound absorption performance. However, these metamaterials usually produce only one narrowband absorption peak. Furthermore, the practical application of most of the acoustic metamaterials is hindered due to the high-cost manufacturing techniques (i.e., 3D printing) and low production efficiency. This project proposes a new classification of metamaterials which is composed of textiles. The textile manufacturing techniques are highly efficient. Textile fabrics can form different resonant elements (e.g., cavity structure, gradient index structure and membrane structure) employing textile technologies and manifold assemblies. Moreover, the different textile resonant elements can combine together to fabricate integrated broadband low-frequency sound absorbers. The knowledge and technologies from acoustic and textile disciplines will be integrated to achieve the aim. One of the most important aims of this project is to develop the metamaterials made by textiles to overcome the shortcomings of currently known metamaterials. This project provides a new possibility to solve the noise problem to increase life quality of the public. Another essential objective is to acquire new knowledge and skills from the host to improve the career competencies and professional experience of the applicant. This objective and sharing the skills with the host will be fulfilled through two-way transfer approaches (e.g., training, presentations, etc.).

Keywords: noise control textile acoustics metamaterial sound absorption