Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Generating a 3D Micro necroptosis induced Myocardial Infarction model (MiniMI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

Cardiovascular disease remains one of the leading causes of death worldwide, with more than 4 out of 5 of these due to heart attacks. Following a myocardial infarction (MI) the loss of cardiomyocytes (CMs) is irreparable due to their non-proliferative state. Following a MI one of the most promising forms of recovery is using therapeutic drugs. Since generating a new drug requires considerable amounts of money and animal testing there is a need for alternative models such as human induced pluripotent stem cell (hPSC) models. hPSCs provide an excellent platform to model cardiac disease, although 2D models are too immature and currently 3D models are not viable for screening of therapeutic compound libraries. To solve this, I aim to implement a 'kill switch' in a subpopulation of a 3D cardiac tissue, that when triggered will induce necroptosis in the population, simulating a localized heart attack. Integrating macrophages will improve the physiological relevance and cTnT-FUCCI CMs will be used to monitor CM proliferation. To generate this innovative, dependable, inducible model of MI using hiPSCs, the project is divided into 3 achievable goals. 1. Generate a hPSC cell line with inducible kill switch system 2. Integrate macrophages into microtissues, induce the kill switch, investigate response to localized cell death and cellular changes producing a scRNA-Seq timeline 3. Incorporate cTnT-FUCCI cardiomyocytes to investigate cardiac regenerative therapies I will receive state-of-the-art genetic modification training to generate the cell line (Goal 1), immune cell generation and integration (Goal 2) and bioinformatic study to identify key pathways identified through scRNA-Seq data generated from the MiniMI model to trial cardiac regenerative compounds (Goal 3). This project will not only generate a reliable model of MI capable for screening of cardioprotective compounds, but also a malleable model suitable for easy adaptation to other researchers interests.

Keywords: inducible disease model,heart attack in a dish,cardiac regeneration,immune cell integration and response
Precision nutrition approach for increasing fibre intake and health using microbiota-matched sustainable fibre sources (FIBRE-MATCH)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Finland,Estonia,Sweden
Call: EIC Pathfinder Challenge: Precision Nutrition (HORIZON-EIC-2023-PATHFINDERCHALLENGES-01, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 3449447.5
EU funding (EUR): 3449447.25
Participants: 3
Project status: SIGNED

The consumption of dietary fibres (DF) should be increased to comply with the dietary guidelines and fuel various beneficial metabolites produced by the gut microbiota, such as short chain fatty acids (SCFA). Microbiota also produces gases that, in sensitive persons including irritable bowel syndrome patients (IBS), trigger disturbing and at worst disabling gastrointestinal (GI) symptoms, leading to the avoidance of fibre-rich foods. The gas formation patterns and amounts are highly individual and interrelated to GI parameters such as gut pH and transit rate. FIBRE-MATCH develops and validates a concept to match DF types to gut microbiome subtypes for optimal metabolic output. The project identifies major DF-metabolising microbiome types prevalent in Europeans using existing metagenomic, dietary and GI symptom data, considering also endogenous glycans. Representative microbiomes and DF will be characterized in vitro to identify metabolic phenotypes. DF combinations yielding an optimal gas to SCFA ratio in vitro will be used to develop fermented food prototypes for proof-of-concept studies in healthy volunteers and IBS patients, to study whether consumption of the microbiome-tailored food improves GI symptoms and IBS markers compared to unmatched fibre, using breath monitoring, metagenome, metabolome and glycan analyses. Biosamples from the healthy subjects will be used to evaluate the effects of DF on risk markers of noncommunicable diseases using metabolomics approaches. A novel database of chemical composition of DF in high-fibre foods will be developed to enable analysis of nutrition-microbiome interactions at functional and molecular level. FIBRE-MATCH fits to the Precision Nutrition Challenge portfolio as it develops fundamental knowledge, capabilities and resources that foster precision nutrition innovations related to individually-tailored microbiome-targeting foods, microbiome-based stratification, and ultimately decreasing the fibre gap.

Keywords: precision nutrition,intestinal microbiome,dietary fibre,glycans,fut2 genotype,short chain fatty acids,intestinal gas,gastrointestinal symptoms,irritable bowel syndrome,
Traumatized Subjects: Mental Health, Violence, and the Fabric of Europe Between the Wars (1918-39) (TRAUMA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 265099.2
EU funding (EUR): 265099.2
Participants: 3
Project status: SIGNED

TRAUMA examines the transnational and trans-medial circulation of key discourses regarding mental health and violence that emerged in interwar Europe (1918–39). I argue that, although the conflict between competing ideologies (Fascism; Liberal Democracy; Communism) undermined the construction of European identity, discourses about mental health and violence played a vital role in fostering the formation of ideas, practices, and values that would later become a central part of the fabric of Europe. Focusing on Britain and Italy and combining cultural studies, medical, legal, and transnational history, TRAUMA explores the depiction of mentally traumatized World War I (WWI) servicemen committing violence. Analyzing sources such as medical and legal texts, novels, periodicals, war memoirs, and handbooks for soldiers, TRAUMA tracks the negotiation of transnational discourses about veterans’ mental health and violent behavior across Britain and Italy. Due to their antithetical nature, nationally, politically, and medically, and the opposite roles played by their veterans after WWI, these two contexts offer a unique window into the European experience of war trauma and its effects (e.g. post-traumatic stress disorder; domestic violence) and allow to trace the cultural shifts and historical processes (e.g. the de-mythization of the soldier; the rejection of the war) that informed the later socio-cultural construction of Europe. Conducted within three leading universities – Padua (return phase), Georgetown (outgoing phase), and Hamburg (secondment) – TRAUMA promotes debates on how cultural studies can address Europe’s most pressing concerns, as testified by the EU4HealthProgramme 2021–27, and fosters international collaborative research on mental health, trauma, violence, and European commonality. Through a range of outreach activities involving academic and non-academic audiences and institutions, TRAUMA will have major impacts at cultural, social, and educational level.

Keywords: transnational literary studies cultural history history of medicine history of law interwar europe mental health violence veterans
Phytoplankton photosynthesis and physiology under P limitation within a context of diversity (PHYTOLIM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 150438.72
EU funding (EUR): 150438.72
Participants: 1
Project status: CLOSED

Aquatic ecosystems offer a wide range of ecosystem services (e.g., climate regulation, carbon sequestration, water treatment, and fisheries). In these ecosystems, Nitrogen (N) and Phosphorus (P) cycles have been modified, leading to an increase in nutrient concentration and changes in the stoichiometry of the element. In marine systems, dissolved N and P are, on average, present in an overall stoichiometry balance called the Redfield ratio (N:P=16). The skewness of stoichiometry is exacerbated by a general effort of countries to reverse eutrophication by reducing only P using water treatment plants. This management solution is leading to a global increase of the N:P in the freshwater and coastal marine systems, amplifying the likelihood of P limitation. Phytoplankton that supports the entire trophic web follows the Redfield ratio and is affected by this unbalanced ratio. Photosynthesis, diversity and physiology of the phytoplankton communities are deeply impacted by these changes, thus stressing the need for understanding this arising issue. This project aims to evaluate how reverse eutrophication (causing high N:P) affects the ecophysiology and productivity of phytoplankton. To explore this issue, nutrient experiments at an unbalanced nutrient ratio (N:P = 90) will be performed with a selection of freshwater and marine species to investigate species on the whole water continuum. An increasing diversity (single species; co-cultures; natural communities for freshwater only) gradient will be used while chemical, physiological, photosynthetic and diversity parameters will be measured. This also includes a temperature variation experiment to study the combined issue of climate change reverse and eutrophication. The information delivered by this project will be critical both for the understanding of the response of phytoplankton communities under unbalanced input and for the problem of reverse eutrophication and climate change to improve water management.

Keywords: phytoplankton photosynthesis redfield ratio physiology biodiversity
Source to Seas - Zero Pollution 2030 (SOS-ZEROPOL2030) (SOS-ZEROPOL2030)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Coordination and support actions
Countries involved: Ireland,Belgium,Netherlands,Austria,Norway,Bulgaria,Greece,Germany
Call: Achieving zero polluted seas and ocean (HORIZON-CL6-2021-ZEROPOLLUTION-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 2998100.5
EU funding (EUR): 2998100.0
Participants: 11
Project status: SIGNED

The overall aim of 'Source to Seas - Zero Pollution 2030 (SOS-ZEROPOL2030)' is to develop a holistic zero pollution framework which can guide the process towards achieving zero pollution in European seas by 2030. Marine contamination (including pollution) occurs as a direct result of human activities on both; land and in the marine environment; and requires urgent attention as healthy and clean seas provide numerous ecosystem services (e.g. food, oxygen production, climate regulation), which are critical for our survival and wellbeing. Given the complex and interconnected nature of marine pollution, the integration of sustainability-focused agendas and circular economy principles and practices is essential for the development of effective actions that can address its impacts. The implementation of processes and measures to reduce marine pollution will have consequences for numerous economic sectors (e.g. agriculture, fisheries, food and beverage industry, waste management, packaging industry, tourism, offshore energy) at multiple scales (local, national, regional and international), framing marine pollution as a considerable global socio-economic challenge that requires active collaboration from multiple stakeholders, across a range of geographic areas. In this context SOS-ZEROPOL2030 aims to co-design, co-produce, and co-deliver a stakeholder lead European Seas zero-pollution framework that provides practical guidance from source to sea addressing shortcomings in marine pollution management and governance. This holistic approach is based on best practice, puts emphasis on human behaviour, socioeconomics and governance; and is underpinned in knowledge about and understanding of current barriers to effective and efficient prevention, reduction, mitigation and monitoring of marine pollution in European Seas.
EU-Africa Concerted Action on SAR-CoV-2 Virus Variant and Immunological Surveillance (CoVICIS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Other health destinations
Action type: Research and Innovation actions
Countries involved: Switzerland,South Africa,France,Germany,Italy,Netherlands,Ethiopia
Call: Cohorts united against COVID-19 variants of concern (HORIZON-HLTH-2021-CORONA-01, 2021)
Start date: 2021-11-01
End date: 2025-04-30
Duration (months): 42.0
Total project cost (EUR): 10048971.68
EU funding (EUR): 10048971.0
Participants: 16
Project status: SIGNED

Despite of the successful advances achieved to date in the fight against the COVID-19 pandemic with the development of vaccines and therapy, the worldwide propagation of SARS-CoV-2 has resulted in the rapid evolution of this virus and in the emergence of variants of concern (VOC) that may dampen the efficacy of the first generation vaccines. To tackle the challenges associated with the VOC, the CoVICIS program is proposing a global approach with a powerful state-of-the-art virologic and immunologic platforms coupled with large genomic surveillance studies and diverse cohorts in EU and SSA. This allows CoVICIS to contribute to the early identification of emerging VOC and address key unanswered questions regarding i) the susceptibility to infection with VOC after a prior infection in the setting of a long-COVID or after vaccination with different vaccines, ii) the risk posed by VOC in immunocompromised patients, and iii) the modalities of infection and immune responses in children. The diversity of the cohorts provides a unique opportunity to study virus evolution in different settings, where SARS-CoV-2-specific humoral and cellular immune responses are predicted to vary very significantly. Beyond the genomic surveillance, the ground-breaking research and innovation of the program is the characterization of virologic and immunologic properties of VOC and the identification of immune correlates of protection after disease or vaccination. CoVICIS’ ambitious goals are only achievable thanks to the existing population studies and cohorts funded by national and international public agencies and public-private partnerships, and the combined collective expertise of CoVICIS partners in the fields of epidemiology, genomics, virology, immunology, data science and public health.

Keywords: emerging voc,vaccination study,long covid,genomic,virologic and immunologic surveillance
Development of sustainable low-NOx and high efficiency Ammonia marine engine (MariDeNOx)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Czechia,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-05-04
End date: 2028-05-03
Duration (months): 24.0
Total project cost (EUR): 207758.16
EU funding (EUR): 207758.16
Participants: 2
Project status: SIGNED

Ammonia (NH3) has gained popularity in recent years as a potential carbon-free fuel, particularly for nautical applications. However, there are clear difficulties in using ammonia as a fuel directly in diesel engine applications due to high auto-ignition temperature, unstable flames and inefficient burning. This issue could be effectively solved by co-firing ammonia with more reactive fuels to improve combustion features. As a result, NH3/H2 co-firing has significant advantages and a wide range of potential in carbon-neutral and low-emission combustion as compared to the traditional co-firing technique with natural gas and diesel. Moreover, the combustion of NH3/H2 produced high NOx and unburnt NH3 which is beyond the acceptable limit. NOx emissions (NO, N2O and NO2) majorly contribute to air pollution. They cause many adverse effects on environment including respiratory tract diseases on human health. Therefore, it is important to overcome NOx and slip- NH3 issues in NH3 combustion engines. To reduce NOx and unburnt NH3 from NH3 combustion marine engines, it is important to understand the formation of NOx through the elementary combustion reaction at the micro-level with advanced lean combustion technology. Therefore, in this proposed research, the two advanced combustion concepts of Turbulent Jet -Reactivity Controlled Compound Ignition (TJ-RCCI) and In-cylinder Reforming Gas Recirculation (IRGR) are projected for the successful reduction of NOx and slip- NH3 in NH3 marine engines with the improvement of thermal efficiency. It assumes that merging TJ-RCCI & IRGR technology should have the following advantages: (1) better combustion efficiency than neat NH3, (2) lower NOx emission, (3) saving fuel energy due to the heat transfer loss of the external reformer, (4) reduce the high cost of catalyst and increases their life period and (5) lower marine GHG emissions.

Keywords: ammonia,hydrogen,methanol,combustion,cfd modelling,reaction mechanism
Making and unmaking refugee camps in Greece: An interdisciplinary study of landscape, social, and material transformations (INMATTER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-16
End date: 2027-06-15
Duration (months): 24.0
Total project cost (EUR): 251578.56
EU funding (EUR): 251578.56
Participants: 1
Project status: SIGNED

In recent years the establishment and subsequent closure of refugee camps across Europe have become emblematic highlighting significant and long-lasting socio-environmental transformations and disruptions. INMATTER addresses this urgent reality by examining the profound impacts of constructing and dismantling refugee camps in mainland and island Greece. While existing literature focuses mainly on policies and interactions among volunteers and refugees, and less on camps’ materialities, INMATTER attempts a shift in perspective. It will incorporate the experiences of local camp workers—whose involvement in camp management has substantially increased—and the affected landscape by combining state-of-the-art approaches from social anthropology, migration and material studies and environmental humanities. Having worked extensively in the humanitarian sector in Greece, I gained deep insights into overlooked relationships, agents, and practices that while matter remain unnoticed. Since 2015, when thousands of asylum seekers arrived on Greek shores, there has been a dramatic shift—from temporary to new permanent camp structures, and from narratives of hospitality to hostility. Violence is now routinized and systematic. Dehumanizing policies and inhumane infrastructures erode empathy, shape the lives and perceptions of refugees and locals, and an ever-changing precarious landscape. Through a nuanced exploration of material remnants, memories and spaces where lives intersect, INMATTER will examine practices of symbiosis, care and healing amid disruption and conflict. Utilizing multimodal ethnography and an engaging audiovisual narrative, it will provide a more inclusive body of knowledge ensuring its findings resonate with broad audiences. Thus, the project’s impact will extend beyond the fellowship, offering crucial perspectives on the transformations of European landscapes and communities in times of crisis, and fostering continued dialogue and understanding.

Keywords: refugee camps,refugees,local societies,landscape,materialities,infrastructures,multimodal ethnography,greece,crisis
High resolution dissection of non-coding determinants of disease (B-ALLeles)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 183600.96
EU funding (EUR): 183600.96
Participants: 2
Project status: CLOSED

While mutations at protein-coding sequences have been extensively characterized, the functional role of disease-associated non-coding variants remains largely elusive. In fact, germline non-coding variants are often associated with increased risk of childhood cancers. In B-cell derived acute lymphoblastic leukemia (B-ALL), the most common type of cancer in children, non-coding sequence variation at lineage-specific genes, such as IKZF1, GATA3 and CEBPE is associated with disease. Interestingly, the strongest risk factor maps at ARID5B, a DNA-binding protein described to promote the removal of repressive histone marks. Still, the role of ARID5B in leukemia and haematopoiesis remains largely uncharacterized. Thus, we hypothesize that non-coding variants associated with B-ALL affect the activity of distal regulatory elements, modulating the expression of ARID5B and other B-cell lineage-specific genes (objective 1). We further postulate that ARID5B promotes the de-repression of lineage-specific genes (objective 2), playing a crucial role in B-cell development and B-ALL initiation and progression (objective 3). To test these hypotheses, I will develop a novel CRISPR screen approach to dissect ARID5B enhancers at single nucleotide resolution (work package 1). I will use a combination of genomics and transcriptomics methods after acute and prolonged degradation of ARID5B to elucidate the molecular function of ARID5B in B-ALL (work package 2). Finally, I will use mouse models and focus on the physiological relevance of ARID5B in B-cell development and leukemia initiation and progression, in vivo. (work package 3). Together, I will dissect the role of non-coding variants at leukemia-associated loci, characterize the molecular function of ARID5B and elucidate the pathophysiological relevance of ARID5B.

Keywords: non coding variants,epigenetics,crispr screens,hematopoiesis,leukemia,enhancers,gwas