Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Legitimacy of Mutual Recognition as a Regulatory Strategy for the Policy Area of Civil Justice in the EU (RECLAIM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 197811.6
EU funding (EUR): 197811.6
Participants: 1
Project status: CLOSED

The research will focus on the principle of mutual recognition and the therewith presumed mutual trust between courts in the policy area of EU civil justice. The principle of mutual recognition, held to be the cornerstone of civil justice, has been transposed from its traditional Internal Market context to this novel policy arena. This transposition raises the question of how the economic and other goals of free movement can be reconciled with due process and access to justice. The research will seek to explore this question in light of the growing body of enacted legislation and case law in the field of civil justice as well as other recent developments. The research will seek to assess whether the various underlying goals are compatible. The research will also seek to assess whether the various overarching measures, including networks and e-justice tools, sufficiently support mutual recognition or whether concerted action in the field of judicial training will come to be seen as necessary. Finally, the research will explore whether mutual recognition is sufficient or whether pressures for further harmonization of civil procedure are emerging. The ensuing responses will fundamentally impact on the perception of the legitimacy of civil justice. The research will be interdisciplinary. First, in exploring the challenges of mutual recognition relevant comparisons will be made to the traditional internal market context and theoretical framework but in particular to the developments in the EU criminal justice field. Secondly, the research will in the discussion on legitimacy seek a dialogue also with the political science debate on the legitimacy of European integration in the Area of Justice, Freedom and Security and on access to justice in an ever globalized world.

Keywords: civil justice,mutual recognition,governance,access to justice,due process,regulatory strategy,harmonization,civil procedural law,legitimacy,european integration
Metabolic switch during mutant-PI3K-induced breast tumorigenesis and metastasis (METABBC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-03-01
End date: 2017-02-28
Duration (months): 24.0
Total project cost (EUR): 199317.6
EU funding (EUR): 199317.6
Participants: 2
Project status: CLOSED

Each year 1.1 million new cases of breast cancer occur among women worldwide and ~50% of the patients succumb to metastatic disease. Although the biology of metastasis has been intensively studied, the cellular and biochemical mechanisms orchestrating its steps remain largely elusive. In this proposal, I will study the metabolic rewiring accompanying breast tumorigenesis and metastasis. Switching of metabolism can be controlled by oncogenic pathways, such as the PI3K/AKT pathway, which is frequently activated in breast cancer through PIK3CA mutations. The host lab has created unique in vivo breast cancer models induced by mutant PIK3CA. Their preliminary data suggest that transformation and metastasis in these models is accompanied by metabolic changes, which present a unique window for therapeutic targeting. In this proposal, I intend to explore the role and molecular details of selected metabolic regulators induced by PI3K mutants during tumor cell migration, invasion and metastasis in vitro and in vivo. To this end, I will combine state-of-the-art gene expression and bioinformatic analysis, metabolomics and multiphoton intravital imaging . Furthermore, I will employ RNAi screens to identify global key metabolic regulators that are essential for breast cancer adaptation to metastatic sites. This study should lead to the identification of new biomarkers and/or targets for metastatic breast cancer.

Keywords: pik3ca,oncogenic transformation,breast cancer,transgenics mouse models,metabolic reprogramming,metabolomics,rnai screens
Memory bias and affective state: a new cognitive indicator of animal affect (MEMORAT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Modelling depression in animals has been a key aim of biomedical research for decades. However, current animal models of depression are increasingly questioned, & standard animal testing situations model only a few symptoms of the disease. To better assess animal depression, a broader set of psychological, neuroanatomical & cognitive alterations evident in depressed patients needs to be considered. The role of cognition, despite being both a risk factor & indicator of human affective disorders, has been particularly neglected in animal models. My project will focus on altered cognition, particularly memory. Using rats, I will test the hypothesis that, just as in depressed humans, animals in negative affective states retrieve negative information from memory better than positive information. Rats’ affective states will be environmentally & pharmacologically manipulated. They will be trained to acquire positive or negative information (e.g. localising food rewards & unpalatable food in an arena), and retrieval of these memories subsequently tested. Furthermore, I will assess whether negative biases in memory retrieval statistically co-vary with other ready-validated depression-like traits in these animals (anhedonia & cognitive pessimism). This multidisciplinary project encompassing animal cognition, psychology, ethology, welfare science & pharmacology will train me in techniques essential for the development of better animal models of affective disorders &, more generally, for scientific progress in the understanding of animal affective states (critical in welfare science, pain research & psychopharmacology). Pr Mendl’s lab (the largest gathering of animal welfare researchers in the world) provides in-depth expertise in these areas, & the University of Bristol is committed to equipping its research fellows with the skills necessary to become internationally-leading principal investigators, which will boost my career development as an independent European scientist.

Keywords: animal emotion,animal welfare,affective state,depression-like state,memory,cognitive biases,pharmacological manipulation,chronic mild stress,environmental enrichment,anhedonia,laboratory rat
Implications of the mesopelagic Remineralization for the OceaN Iron Cycle (IRON-IC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-05-15
End date: 2017-05-14
Duration (months): 36.0
Total project cost (EUR): 279172.5
EU funding (EUR): 279172.5
Participants: 1
Project status: CLOSED

The bioavailability of iron (Fe) has been shown to limit primary production in up to 50% of the ocean’s waters. As a result of its function in modulating Earth’s climate, the role of Fe supply on the oceanic carbon cycle has received widespread attention over the last two decades. However, much of the research to date has focused new sources Fe, and little attention has been directed toward controls on the supply of recycled Fe. Within the mesopelagic zone (the layer underlying the euphotic zone and extending to 1000 m), heterotrophic bacterial activity results in a dramatic decrease in the organic carbon exported from surface waters. For this depth range of importance for predictions of future changes in the ocean’s carbon cycle, bacterial remineralization and the fate of particulate iron (PFe) are, paradoxically, poorly understood. The proposed project seeks to better understand the functioning of the ocean’s Fe cycle through investigations of the bacterial remineralization of PFe within the mesopelagic zone. Using an innovative technical approach, the first part of the project will consist of the simultaneous and in situ measuring of bacterial remineralization rates and dissolved iron (DFe) release within the mesopelagic zone. Since the speciation of released DFe has major consequences on the bioavailability of upwelled fluxes of Fe, the second part of the project will consist of determining, using complementary in vitro experiments, the concurrent release of iron-binding ligands, as well as their size class (soluble or colloidal), during bacterial particle remineralization. This experimental work will be performed at different times of the year within two oceanic regions (the Southern Ocean and the Mediterranean Sea) that are characterized by contrasting Fe supply mechanisms in order to determine whether the fate of PFe at depth is primarily driven by particle properties that are imprinted within the surface ocean or in mesopelagic particle transformations.

Keywords: climate change,biological pump,ocean iron cycle,recycled iron,bacterial remineralization,mesopelagic zone,iron speciation and bioavailability
The phenomenological concept of institution: event, history, symbolic. (PHENINST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

The project aims at illustrating the specificity and fecundity of the phenomenological concept of Stiftung/“institution”. Thanks to its joint reference to the taking place of an event and the opening of a new dimension of meaning, the concept of institution allows us to map out a rich and articulated field of research, the potential of which still awaits to be fully fleshed out in the literature. The project also aims at filling this gap, in particular by writing some papers and a book on the theme. The concept of institution, originally introduced by Husserl, shall be analyzed with reference to several authors belonging to the phenomenological and post-phenomenological tradition: Heidegger, Merleau-Ponty, Derrida and Richir. The aim of the project is to analyze several theoretical issues which the concept of institution allows us to make emerge across the texts of these authors. The project is organized around four theoretical questions and thus structured into four corresponding phases: 1) a general theoretical analysis of the concept of institution as an event – its a-subjective nature, its empirical and transcendental status, its problematic connection to an Urstiftung, the relationship between the event of the institution and the thereby instituted field; 2) the study of the historical institution, with the aim of elaborating the conception of historicity implied by the very concept of institution; 3) the study of the relationship between institution and culture, with the aim of elaborating a conception of the different symbolic formations as “institutions”; 4) an investigation of the relationship between, on the one hand, symbolic and historical institutions, and, on the other, pre-linguistic and perceptual experience. The project also implies a series of interdisciplinary connections in the field of social and human sciences, that I will explore with particular regard to the theory of historiography and anthropology.

Keywords: phenomenology,post-phenomenology,heidegger,merleau-ponty,derrida,richir,stiftung/institution,event,transcendental/empiric,philosophy of history,culture,symbolic,language/experience
Targeting atherosclerosis: Raman-spectroscopy validated, triggered release of drugs from de novo phospholipid-incorporating liposomes by sphingomyelinase enzymatic degradation of the membrane bilayer. (SMASE LIPOSOME)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-10
End date: 2017-01-11
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Cardiovascular diseases are the world’s number one killer, causing 43% of all deaths and costing the EU 192 billion Euros annually. Delaying their progression using e.g. targeted drug delivery to atherosclerotic plaques is a number one priority in modern healthcare. The enzyme sphingomyelinase (SMase) is upregulated in atherosclerotic plaques. In vivo, dysregulation of enzymatic conversion of the cell membrane phospholipid sphingomyelin (SM) to ceramide by SMase leads to a change in ceramide concentration. This causes endothelial dysfunction, atherosclerosis, ischemic heart disease, emphysema, cancers, cystic fibrosis and depression. SMase-targeting drugs are an emerging research topic but no localised delivery vectors to alleviate negative systemic side effects are yet reported. This project marks two world-firsts: SMase as a target for drug delivery, and a liposome formulation from which release is not only targeted but ENDOGENOUSLY TRIGGERED by the target enzyme. SM analogues will be synthesised and incorporated into the membrane bilayer of drug-loaded liposomes. The ceramide analogue products they form on enzymatic reaction with SMase create drug-eluting pores in regions of high SMase activity (i.e. atherosclerosis) and release an encapsulated drug, but unlike natural ceramides do not interact with cells to trigger responses such as apoptosis. For the first time, toxicity of SM analogues and efficacy of the optimised liposome delivery vectors will be measured on human vascular endothelial cells using state-of-the-art live cell Raman microspectroscopy, which can highlight subtle differences in lipid and cholesterol production and distribution and cell cycle. This never before reported drug delivery platform can be translated to treat many SMase dysregulating pathologies and is a major breakthrough in liposomes for TRIGGERED drug delivery. The impact on health and society of locally treating these pathologies with SMase-targeting drugs cannot be overestimated.

Keywords: liposomes,targeted drug delivery,live cell raman microspectroscopy,sphingomyelinase,atherosclerosis,organic chemistry.
high-throughput screening for high-grade glioma (HTS-4-GBM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 269743.8
EU funding (EUR): 269743.8
Participants: 1
Project status: CLOSED

Glioblastoma is the most common and most malignant form of primary brain tumour. It affects both children and adults and remains virtually incurable. As a result, it is a leading cause of cancer-related deaths and more effective therapeutic strategies are urgently needed. Herein, I propose to use an innovative methodology combining high-throughput drug screening, pathway analysis and functional genomics to simultaneously develop new treatment modalities and identify novel therapeutic targets / biomarkers for glioblastoma. Using high-throughput screening based on drug repositioning principles, I will first identify already approved drugs that can increase the efficacy of conventional and targeted therapies for glioblastoma. Taking advantage of the first-class and clinically-relevant models of glioblastoma available in the host institution, I will then evaluate the therapeutic potential of the hit compounds in vivo. In parallel, using pathway analysis tools and the known targets of the hit compounds, I will generate a list of genes potentially involved in treatment resistance in glioblastoma. The significance of these genes will then be validated using RNA interference-based high-throughput screening. Finally, the patho-physiological role of the key genes identified and validated by this approach will be investigated by functional genomics and their prognostic and/or predictive value will be evaluated using the unique collection of clinically-annotated samples from glioblastoma patients available in the host institution. Overall, this research project will lead to the identification and pre-clinical validation of innovative treatment combinations for glioblastoma, and the discovery of novel therapeutic targets and biomarkers to be used in future clinical trials. It will thus increase our understanding of the biology and resistance to therapy of glioblastoma and has the potential to significantly impact on clinical practice and patient outcome.

Keywords: glioblastoma,high-throughput screening,drug repositioning,chemotherapy,radiotherapy,targeted therapy,functional genomics
Facilitation and Inhibition of Multisensory Integration via Neural Oscillations (ISMINO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-02-01
End date: 2018-11-15
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

The brain is constantly challenged to decide between integrating or segregating multiple sensory signals. For instance, at a busy party, we should integrate the facial movements of the speaker we are listening to with the speech he produces whilst ignoring other voices. Despite its importance for many daily situations, little is known about how the brain computes this decision. This multidisciplinary proposal combines psychophysics, Bayesian Causal Inference, EEG/MEG and concurrent EEG-fMRI to characterise the computational operations and neural mechanisms for arbitrating dynamically between multisensory information integration and segregation. In particular, we will probe the role of phase resetting, alpha oscillations and cross-regional neural coherence. First, we will investigate how the brain utilises multiple bottom-up correspondences such as audiovisual synchrony and motion congruency. Second, we will investigate how multisensory integration is jointly shaped by top-down prior congruency expectations and bottom-up sensory correspondences. We expect that temporal synchrony is critical for mechanisms of phase resetting, while dynamic motion congruency that becomes only later available may be more clearly sustained by inter-regional coherence. Oscillatory alpha activity will play a key role in top-down influences of prior congruency expectations. Using simultaneous EEG-fMRI, we will investigate how the multisensory network is modulated dynamically by alpha power in visual cortices on a trial-by-trial basis. Collectively, this proposal will significantly advance our understanding of the neural and computational mechanisms underlying information integration and segregation, one of the brain’s most fundamental capacities. It will also provide critical tests for influential theories of oscillatory activity. he research outcome will have important implications for translational fields such as cognitive decline in ageing, robotics and performance enhancing technology.

Keywords: multisensory integration,neural oscillations,bayesian causal inference,congruency,prior expectation,communication through coherence,eeg,meg,fmri,psychophysics,dynamic causal modelling
Meninges: a new perivascular stem cells niche for widespread neurogenesis (MENINGES-NET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-03-01
End date: 2016-02-29
Duration (months): 24.0
Total project cost (EUR): 235000.0
EU funding (EUR): 235000.0
Participants: 1
Project status: CLOSED

Adult neural stem cells (NSC) have been mainly described to be restricted within limited areas of the brain thought to be germinal remnants. However, new potential sites of NSCs activity have been recently described. The multiple locations of NSC niches, that increase in diseases, leaves open the question of whether and how these structures communicate throughout long distance. I and others have described a new player in the neurovascular unit: the perivascular meningeal stem cells. This cell population endow of neural differentiation potential and can migrate to the injured area contributing to brain parenchymal reaction following injury. With this IEF, I will have the great opportunity to join the Neurovascular link lab of Prof P. Carmeliet, Leuven, Belgium, to investigate the hypothesis that a subtype of perivascular cells may contribute to neuro-angiogenesis both in health and disease. I will address the following aims: (i) To genetically target perivascular meningeal stem cells. (ii) To understand the contribution of perivascular meningeal stem cells to neuro-angiogenesis in physiological and (iii) pathological conditions (stroke and cancer). I will follow the fate of perivascular meningeal stem cells by gene fate mapping them combining several techniques, including mouse transgenesis, stereotactic viral vector transduction and in vivo plasmid electroporation. Moreover, I will investigate possible molecular mechanisms of stem cell differentiation by targeting relevant metabolic pathways. Finally, I will use laser induced photoactivated stroke and genetically knock-in/-out cancers as diseases animal models. This multidisciplinary approach will eventually shed the light to identify new player in the complex events occurring in endogenous neural regeneration and cancer. This experience will give me the chance to learn high impact research and to publish in top journals. This will dramatically improve my possibility to start an independent research career.

Keywords: meninges,neuro-angiogenesis,neural stem cells,stem cell niche,vascular biology,metabolism,transgenesis,neurological diseases,cancer