Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Inverted core/shell Nanocrystals: the future Nanomaterial for the Visualization of Neuron activity (iNano)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

The main goal of the iNano project is the development of a new synthesis approach for Indium phosphide (InP)-based semiconductor nanocrystals (NCs), which will be used to record and stimulate neuron activity in dorsal root ganglion (DRG) neuron cells. Although Cd-based NCs are well studied, their application in commercial products is hampered by the presence of the toxic heavy metal ion cadmium. Due to similar optical properties InP NCs are a promising alternative but still facing three major challenges in their synthesis: i) polydispersity, ii) NCs with PL in the NIR region and iii) synthesis of multidimensional NCs. In the iNano project a new synthesis protocol will be established based on a seeded-growth method, which will allow the preparation of monodisperse isotropic and for the first time also of anisotropic InP based NCs. This will be possible by the use of heteroelement seeds (zinc chalcogenides), whose structures govern the InP growth kinetics and shape. The dependency of the PL on the thickness of the InP layer will allow to push the PL to the NIR. By in depth photophysical characterization on the ensemble and single-particle level and also regarding their non-linear properties, unique insights will be gained leading to a better understanding of the optoelectronic transitions and the influence of the shape on the optical properties. iNano will shed a first light into the versatility of the InP NCs for neuroscience, investigating their performance under one-photon and multiphoton excitation to record and stimulate neuron activity. Due to the higher voltage sensitivity, better chemical stability, and negligible photobleaching effects, these nanomaterials are more attractive than up to know used tools for the measurement of the electric field generated by an action potential. The lower toxicity of the InP NCs will making the here developed protocols of high interest to neuroscientist and for the Eu initiative "Human Brain Project".

Keywords: iii v nanocrystals,seeded growth,two photon imaging
PeRsOnalized nutriTion for hEalthy livINg (PROTEIN)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive agri-food sector for a safe and healthy diet
Action type: Innovation actions
Countries involved: Ireland,Germany,Spain,Italy,Italy,Belgium,Belgium,Greece,Serbia,Netherlands,Netherlands,United Kingdom,Portugal,United Kingdom,Luxembourg,Portugal
Call: Personalized Nutrition (H2020-SFS-2018-1, 2018)
Start date: 2018-12-01
End date: 2022-11-30
Duration (months): 48.0
Total project cost (EUR): 8138951.25
EU funding (EUR): 6999472.5
Participants: 26
Project status: SIGNED

Proper nutrition is essential for good health, well-being and the prevention, mitigation or treatment of a number of non-communicable diseases (NCDs). Food is not only a source of calories, but also a complex mixture of dietary chemicals, some of which are directly related to cardiovascular diseases, diabetes, allergies and some types of cancer. Foods, diet and nutritional status, including overweight and obesity, are also associated with elevated blood pressure and blood cholesterol or even resistance to the action of insulin. These conditions are not only risk factors for non-communicable diseases, but major causes of illness themselves. However, today's diet is characterized by irregular and poorly balanced meals. Unhealthy eating habits in our daily life are not only risk factors for non-communicable diseases, but also major causes of stress and tiredness, i.e., lack of energy. Knowledge about our dietary habits based on the analysis of diverse types of information, including individual parameters, can contribute greatly towards answering key questions to respond to societal challenges regarding food and health. Motivated by the aforementioned, the PROTEIN project aims to develop an end-to-end ecosystem that will engage people to a healthy, pleasurable, nutritional and sustainable diet by offering a daily program adapted to their needs and driven by their personal preferences, physical and physiological characteristics as well as their health status. Specifically, the main objective of PROTEIN is to create an ICT-based system for providing personalized nutrition based on the collection and analysis of large volumes of data related to users' dietary behavioural patterns, physical activity and individual parameters. PROTEIN proposes a radically novel approach to advice and support consumers in everyday living, while ensuring users’ privacy protection i.e., data will be anonymized and securely stored in the Cloud for processing.

Keywords: personalised nutrition,health,wellbeing,prevention,ncds,physical activity
Multifunctional miRNA-targeting nanodevices for pluripotent cancer theranostics (MIRNANO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-15
End date: 2020-01-14
Duration (months): 36.0
Total project cost (EUR): 244269.0
EU funding (EUR): 244269.0
Participants: 2
Project status: CLOSED

WHAT: MIRNANO project is an interdisciplinary nanotechnology-driven program in which the fields of nanomaterial and DNA functional engineering are merged to develop innovative nanodevices for pluripotent targeted cancer treatment. The leading idea is to focus on aberrantly expressed microRNAs (miRNAs) as targets of the proposed therapeutic care, which allows for tailoring of the action to the genetic expression of a specific tumor. WHY: Current chemotherapy still relies on an untargeted paradigm, which suffers from poisoning side effects and lacks a focused action over the tumor area. Molecular biology has definitely demonstrated the pivotal role played by microRNAs in cancer development and metastasis progression, therefore anti-miR therapy is the ultimate strategy to bet on. Working at the nanoscale will allow to achieve advanced nanomaterials that can home to the specific tumor tissue and silence the aberrantly expressed miRNAs producing a downstream therapeutic effect. HOW: The proposed program is a very challenging project that aims to provide a groundbreaking contribution to cancer treatment. Nanomaterial science is primarily involved in this project. Porous silicon nanoparticles are intended to be used as luminescent, biodegradable, and biocompatible platforms for producing the anti-miR nanodevices. Functionalization with tumor-penetrating peptides will allow to achieve homing of the particles to the site of action, thus specifically targeting the tumor environment. Anti-miR nucleic acids, carried and delivered through the silicon nanocarriers, will ensure knockdown of target miRNAs, inducing downstream suppression of tumor growth. A complementary engineering of the anti-miR nucleic acid unit through rational design of advanced switching structures will allow for developing programmed miR-responsive tools, which are meant to reinforce the primary anti-miR effect with an extra-therapeutic action.

Keywords: microrna targeting,nanomedicine,porous nanomaterials,nucleic acid engineering,hybrid biomaterials,targeted cancer treatment
Tests Of Fundamental Physics With Atomic Parity Violation in Ytterbium (YbFUN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany,Greece
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2020-12-01
End date: 2026-11-30
Duration (months): 72.0
Total project cost (EUR): 1455244.0
EU funding (EUR): 1124355.66
Participants: 2
Project status: SIGNED

This project aims to establish a novel platform for fundamental tests in nuclear and particle physics, based on detecting isotopic variation of parity violation in atomic nuclei. Atomic probes in tabletop experiments offer a unique approach to testing fundamental physics, complementary to high-energy-physics experiments in large facilities. In particular, atomic parity violation (APV) provides a window into the effects of weak interaction in atoms. Recent observations by our team on how the APV effect varies among a chain of ytterbium (Yb) isotopes motivate the use of this method as a versatile probe of nuclear and particle physics. More specifically, comparing the APV effect in different isotopes of the same atomic species is a sensitive tool to study the distribution of neutrons in the nucleus, which in turn is closely related to the structure and size of neutron stars. The method is also a probe of additional vector bosons, beyond the Standard Model of particle physics. Finally, the study of nuclear-spin-dependent contributions to the APV effect in isotopes with nuclear spin is a sensitive way to investigate intranuclear weak interactions, which are currently poorly understood. The objective of the YbFUN project is to substantially expand existing approaches to probing isotopic APV variation and to establish the method as a powerful tool at the interdisciplinary junction between atomic, nuclear and particle physics. Towards this goal, we will i) employ high-precision measurements of isotopic variation of the APV effect in Yb to probe the neutron distribution in the Yb nucleus and thus help answer questions regarding the size of neutron-rich nuclei and neutron stars; ii) make use of the isotopic comparison method to explore electron–nucleon interactions mediated by potential additional Z bosons; and iii) undertake studies of spin-dependent APV to advance the fundamental understanding of intranuclear weak forces.

Keywords: weak interaction,neutron skins,additional bosons
Deciphering molecular pathways of circadian clock communication (CIRCOMMUNICATION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-03-01
End date: 2024-02-29
Duration (months): 72.0
Total project cost (EUR): 1999945.0
EU funding (EUR): 1999945.0
Participants: 1
Project status: SIGNED

The overarching objective of this interdisciplinary project is to elucidate mechanisms through which billions of individual clocks in the body communicate with each other and tick in harmony. The mammalian circadian timing system consists of a master clock in the brain and subsidiary oscillators in almost every cell of the body. Since these clocks anticipate environmental changes and function together to orchestrate daily physiology and behavior their temporal synchronization is critical. Our recent finding that oxygen serves as a resetting cue for circadian clocks points towards the unprecedented involvement of blood gases as time signals. We will apply cutting edge continuous physiological measurements in freely moving animals, alongside biochemical/molecular biology approaches and advanced cell culture setup to determine the molecular role of oxygen, carbon dioxide and pH in circadian clock communication and function. The intricate nature of the mammalian circadian system demands the presence of communication mechanisms between clocks throughout the body at multiple levels. While previous studies primarily addressed the role of the master clock in resetting peripheral clocks, our knowledge regarding the communication among clocks between and within peripheral organs is rudimentary. We will reconstruct the mammalian circadian system from the bottom up, sequentially restoring clocks in peripheral tissues of a non-rhythmic animal to (i) obtain a system-view of the peripheral circadian communication network; and (ii) study novel tissue-derived circadian communication mechanisms. This integrative proposal addresses fundamental aspects of circadian biology. It is expected to unravel the circadian communication network and shed light on how billions of clocks in the body function in unison. Its impact extends beyond circadian rhythms and bears great potential for research on communication between cells/tissues in various fields of biology.

Keywords: circadian clocks,metabolism,oxygen,entrainment
Advanced Networking for Nuclear Education and Training and Transfer of Expertise (ANNETTE)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Support the development of nuclear competences at Union level and socio-economic aspects
Action type: Coordination and support actions
Countries involved: Germany,Spain,Spain,Italy,Germany,Germany,Germany,Italy,Germany,Belgium,Belgium,Finland,Sweden,Belgium,Romania,Slovenia,France,France,Czechia,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Education and training (Bologna and Copenhagen processes) (NFRP-2014-2015, 2014)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 3184447.5
EU funding (EUR): 2517399.0
Participants: 29
Project status: CLOSED

The present situation of nuclear energy in Europe asks for a continuing effort in the field of Education and Training aimed to assure a qualified workforce in the next decades. In this scenario, the present proposal is aimed at enhancing and networking the Europe-wide efforts initiated in the past decades by different organisations belonging to academia, research centres and industry to maintain and develop Education and Training in the nuclear fields. This will allow consolidating, developing and better exploiting the achievements already reached in the past and to tackle the present challenges in preparing the European workforce in the nuclear fields. The main objectives of the proposal are: 1. SURVEY AND COORDINATION OF NETWORKING IN E&T AND VET IN THE NUCLEAR AREAS 2. DESIGN AND IMPLEMENTATION OF COORDINATED E&T AND VET EFFORTS (Master and Summer Courses for continuous professional development) 3. GENERATIONAL TRANSFER OF EXPERTISE (Sustainable production of educational material) 4. CROSS BORDER TRANSFER OF EXPERTISE (Implementation of ECVET based exchanges among industrial bodies) 5. REINFORCING ETI ACTIONS FOR SHARING AND ENHANCING NUCLEAR SAFETY CULTURE COMPETENCE 6. FACILITATING THE NUCLEAR TRANSITION IN FUSION: COORDINATING THE E&T ACTIONS The European Nuclear Education Network (ENEN), as coordinator of the proposed action, together with the other Participants, is committed to pursue the above objectives, being fully coherent with the ones suggested in the call (NFRP10) and proposed by the SET Plan Roadmap for Education and Training for the nuclear sector, tightening at the same time the links among the different nuclear areas and better coordinating their contributions in the E&T fields. Strict links with the SNE-TP; IGD-TP and MELODI platforms and other relevant associations and bodies (EHRO-N, NUGENIA, EUTERP, IAEA, HERCA, etc.) will be implemented to assure coherence of this effort with similar other efforts going on in Europe.

Keywords: advanced networking,borderless mobility,ecvet,advanced master,summer courses,continuous professional development
LUCINE: THE COMPREHENSIVE, PERSONALIZED AND SAFE eHEALTH SOLUTION THAT ACCURATELY MEASURES, ANALIZES AND RELIEVES PAIN (LUCINE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

LUCINE is a revolutionary, clinically validated, solution for chronic pain diagnosis and management. Chronic pain is a global pandemic that affects 100 million Europeans. The management of pain is not adapted to the needs of the patients or the expectations of health professionals. When it becomes chronic, pain becomes an illness and has dramatic social, economic and public health impacts. Each year, approximately 1 in 5 Europeans are affected by chronic pain. Chronic pain adversely affects patient’s quality of life and can even limit a person’s movements, further interfering with daily activities. Health professionals lack the time and the tools to address a phenomenon as personal and subjective as pain. Still, chronic pain accounts for 22% of primary care physicians consults, with over a third of adult appointments involving a patient in chronic pain. The cost of pain at the European level can be estimated at € 441 billion. As a company, LUCINE is a leading innovator on pain diagnosis and management. LUCINE ́s customized mobile application is the first digital solution that can measure and analyse all facets of a patient’s pain, in 45 seconds. It utilises the smartphone’s camera and microphone to measure a patient’s pain levels through facial, postural, vocal and environmental recog¬nition. It provides an objective measurement of the patient’s pain level on a scale of 1 to 100. Moreover, LUCINE is the first “digital pharmacy” that offers personalised immersive healthcare solutions to relieve pain. Yet it relies on existing “devices” (smartphone, VR sets), by offering a variety of care adapted to the environment, pain levels and patient’s profile. Based on the data collected our system adapts the treatment to the tastes, attitudes, habits, and culture of the user. LUCINE’s products are targeting a large global market of € >350 billion represented by the over 1.5 billion individuals across the world who sufferfrom this type of pain.

Keywords: digital therapeutics
Paired Electrochemical Oxidation process for feasible industrial production of the crucial FDCA building block for the bioplastic industry (PairElOx)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Switzerland
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-04-01
End date: 2018-07-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

AVA Biochem is a specialty chemicals company and produces the premium platform chemical 5-Hydroxymethylfurfural (5-HMF) from renewable biomass. We are the owner of the world’s 1st industrial plant for production of 5-HMF from biomass. Recently the company has added 2,5-furandicarboxylic acid (FDCA) to its product portfolio. FDCA is considered as a top 12 Top Value-Added Chemicals, which can be used in a wide variety of applications, most significantly in the production of Polyethylene Furanoate (PEF), a polyester ideal for packaging. Most plastic bottles are made from PET (oil-based polyethylene terephthalate) but PEF is a superior polymer. It offers a better barrier for CO2 and O2, is stronger but thinner and has a longer shelf life. PEF is a bio-based substitute for oil-based PET. However, in the market, there is not an industrial commercial process to produce FDCA because of the price. After a long R&D way, we offers an HMF from biomass, which a price more than 2000% lower than currently. Diverse approaches for the oxidation of HMF to FDCA have been developed usually with uncompleted conversion. However, we have developed a continuous, integrated pilot plant for the oxidation of HMF in water with paired electrochemical oxidation to obtain FDCA and its purification. This technology has advantages since the oxidant is substituted by electrons, and the oxidation occurs at both anode and cathode, thus the produced waste and energy are minimized. Applying this concept we obtain FDCA with yields >99% in the lab and a purity of 99.95 wt%. The selectivity is >90% without any dangerous by-products. The process also takes place in water so neither hazardous organic solvents are necessary. It is considered as a green process because an energy savings of 66% and GHG emissions reductions by 35% are realized. Thus, the bio-based FDCA end-product will be offered to the market at much lower price than currently, having a crucial role to play in the PEF bioplastic packaging.

Keywords: 5 hydroxymethylfurfural,fdca,5 furandicarboxylic acid,polyethylene furanoate,paired,electrochemical,oxidation,electrosynthesis,biomass,bioplastic,green process,feedstock,biobas