Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Protein Dynamics in Antiviral Processes (ProDAP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-04-01
End date: 2024-03-31
Duration (months): 60.0
Total project cost (EUR): 2169555.0
EU funding (EUR): 2169555.0
Participants: 1
Project status: SIGNED

The innate antiviral defense system is of central importance to protect from viral pathogens. Its ability to mitigate a detrimental outcome of an infectious event relies on interactions that happen between viral and host-derived proteins as well as on signalling cascades that regulate the cellular response. However, despite the importance of these interactions, the involved processes and proteins are not yet fully understood. We established state of the art mass spectrometry techniques and statistical modelling to characterise protein-protein interactions that are affected by viruses. We identified a class of proteins we name “viral affected proteins changing their interaction” (iVAPs). In addition, we established protein turnover rates of >6900 proteins in virus infected cells and identified a group of “viral affected proteins changing turnover rates” (tVAPs). tVAPs are regulated on basis of protein stabilisation, degradation or translation. Preliminary experiments show critical importance of iVAPs and tVAPs in antiviral immunity, suggesting functional similarities to Interferon stimulated genes (ISGs). Alike ISGs, VAPs therefore represent a critical component of the immune system. ProDAP will establish the function of iVAPs and tVAPs in the antiviral immune response. Systematic screens employing depletion and overexpression experiments, integration of these data in functional networks and mechanistic follow up studies will be performed. Already identified and new candidate proteins will be tested mechanistically for their immune-regulatory capacity and their influence on virus infections in vitro and in vivo. ProDAP will allow insights in yet unstudied modulators of host-pathogen interplay and will influence our current understanding of immune regulation in general. It is well established that ISGs are of central importance to defend virus infections and we hypothesize that VAPs may fulfil a similarly important protective function that has yet not been elucid
Services to enhance the innovation amangement capacity of SMEs in Roamania macro-region 1 (InnoCap Transylvania)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Romania,Romania,Romania,Romania,Romania
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 39176.25
EU funding (EUR): 39176.25
Participants: 7
Project status: CLOSED

InnoCap Transylvania - Services in support of innovation for Romanian SMEs The objectives of this proposal are the following: - increase the efficiency and efectiveness of innovation process of local beneficiaries of SME Instrument program and innovative SMEs with significant innovation activities and high potential for internationalization; - facilitate SMEs access to consultancy services for innovation management to address bottleneck to creating an economic impact; - support innovative SMEs to raise the company's profitability and competitiveness on international market.

Keywords: increase the efficiency and effectiveness of innovation process of local beneficiaries
MONOLITHIC BATTERIES FOR SPACESHIP APPLICATIONS (MONBASA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Sweden,United Kingdom
Call: Bottom-up space technologies at low TRL (H2020-COMPET-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 1264025.0
EU funding (EUR): 996465.5
Participants: 4
Project status: CLOSED

The overall ambition of MONBASA is to develop an energy storage system for small satellites (nano-/microsatellites) that outperforms existing solutions and can be integrated with MEMS technology. To be both, applicable and competitive, the novel solution will have to respond to specific needs, namely: (1) high energy efficiency and density, (2) small size and low weight, (3) high reliability (4) compliance with existing standards and regulation, and (5) high cost-efficiency. Any energy storage system will have to first demonstrate its ability to store energy efficiently, within specific power, lifetime and safety specifications and eventually be available at a cost that is ultimately affordable by the nano/microsatellite sector, which is highly cost-sensitive. Worldwide nanosatellite sector is continuously growing and three main aspects are driving the development: miniaturization, standardization and cost. However Europe has seriously fallen behind competitors from the US and Asia, with regard to R&D in the field of energy storage, which is one of the crucial components for improving and widening small satellites performance and applications. With its approach, MONBASA is bridging the gap between R&D and market, with the desired future impact being that the provision of tailored energy solutions becomes a European discipline and business. By bringing together a cross-sector consortium that comprises actors from the areas of energy R&D, processing technologies and space applications, the exact needs of the space industry will be considered for innovative energy storage solutions at low TRL levels. This will not only significantly increase future market uptake of a novel solution that so far is in the state of basic research, but it will foster urgently needed intense knowledge exchange between non-space and space actors for jointly developing novel solutions for a field of expectedly strong growth.

Keywords: thin film li ion batteries,monolithic battery,all solid state battery,solid electrolytes,mems,nanosatellites
Induction Starter Generator (ISG)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France
Call: HVDC Starter/Generator (H2020-CS2-CFP01-2014-01, 2014)
Start date: 2016-04-01
End date: 2019-12-31
Duration (months): 45.0
Total project cost (EUR): 1361702.5
EU funding (EUR): 953191.75
Participants: 1
Project status: CLOSED

The objectives of the project Induction Starter Generator (ISG) is to design, develop, manufacture, test and qualify an innovative TRL6 High Voltage Direct Current (HVDC)/Low Voltage Direct Current controlled Starter/Generator (S/G) intended to be installed on the LiFeCraft Helicopter ISG proposes solutions that will be compatible to the call requirements and will be interfaced to the two electrical networks, one at 270Vdc H/C network compliant with MIL-STD-704-F and one at 28Vdc H/C network compliant with EN2282. ISG technical proposal innovation consists of the use of ground applications like automotive engine starter/generator or wind turbines electrical generator that were never used before in aeronautical environment and their adaptation is a real technological innovation that leads, thanks to the development to be performed in this project to a viable solution for demonstration as required by the CFP. The main idea is to use an induction machine associated to power electronics over options like the classic aeronautic Wound Field or brush DC machine, but also over common ground applications like high powered PMG machines, variable reluctance machines or claw-poles machines usually used in automobile industry. The proposed innovative system is composed of one rotating machine - Induction Starter/Generator and an Electrical Control Unit which provides the ISG start control and generation control functions and the electrical power to the H/C. The ISG is a three-phase squirrel cage induction machine drive by the H/C engine turbine The ECU is composed of two power converter: - a bi-directional inverter connected to the +270Vdc internal power bus to pilot the ISG in both start and generation mode, - a DC/DC converter powered by the +270Vdc internal power bus to supply the H/C 28Vdc network in generation mode.

Keywords: electrical generator,engine electrical starter,electrical power converter,hvdc network,hvdc starter,hvdc generator,lvdc network,lvdc starter,lvdc generator,wound field machine,certification
Design, Synthesis, Characterization and Catalytic Application of Silyliumylidene Ions (SILION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-12-01
End date: 2021-05-31
Duration (months): 66.0
Total project cost (EUR): 1499942.0
EU funding (EUR): 1499942.0
Participants: 2
Project status: CLOSED

This ERC-StG 2014 proposal, SILION, outlines a strategy for the one-pot synthesis, characterization, and reactivity investigation of a positively charged, electron-deficient, highly Lewis acidic, cationic silicon(II) species, denoted “silyliumylidene ions”. Silyliumylidene ion has only four valence electrons, consisting of a lone pair of electrons and two vacant orbitals on the central silicon atom. It will be expected to bear the best combined character of both silylenes as silicon analogue of carbene and silylium ions as silicon analogue of carbenium ions. The program described herein is also aimed at the development of silyliumylidene ion as novel catalysts based on main group elements. The proposed silyliumylidene ions should fulfil the following criteria: a) compounds can be synthesized by a facile one-pot reaction of the corresponding dichlorosilane with two equivalents of N-heterocyclic carbenes, b) silyliumylidene ions will potentially possess three reactive sites including (i) a lone pair at the silicon center, (ii) p-orbital at the silicon center, and (iii) N-heterocyclic carbenes, c) thanks to their strong sigma-donor as well as pi-acceptor ability, the highly reactive silyliumylidene ions are expected to serve as innovative reagents for activation of organic small molecules, excellent catalysts, and strikingly versatile coordination ligands toward transition metals. The target of this proposal is the introduction of facile accessible silyliumylidene ions, which are combined the best properties of silylene and silylium ions, and development of its reactivity and catalytic activity. The synthesis of silyliumylidene ions is straightforward and should allow the investigation of electronic and steric properties of the substituents and N-heterocyclic carbenes. It is anticipated that novel silyliumylidene ions can be used for a promising new building block for low-valent organosilicon compounds and high-performance catalysts.

Keywords: main group chemistry,silicon,silylene,silylium ion,transition metal complex,catalysis,small molecule activation
UNLOCKing next generation computer-guided Enzyme Discovery and Design. (UNLOCK-EDD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-10-01
End date: 2022-03-31
Duration (months): 30.0
Total project cost (EUR): 1859281.25
EU funding (EUR): 1301496.88
Participants: 1
Project status: CLOSED

ZYMVOL is start-up specialized in computer-driven biocatalyst discovery and development for the pharmaceutical and fine chemical industry. We harness the power of high-performance computing to identify and optimize custom-made biocatalysts that deliver additional value. Biocatalysts are enzymes that accelerate industrial chemical reactions and have multiple applications for the synthesis of chemical compounds. Engineered enzymes can provide improved performance, representing a unique advantage. The protein engineering market is a fast-growing business estimated to reach 2.67B€ by 2024 (CARG +15%). The main obstacle today to performance enhanced biocatalysts is that current enzyme engineering processes rely on slow and costly experimental tests with uncertain outcomes. Our in-silico engineering platform can rapidly find thousands of enzyme variants delivering reliable predictions, that allow to replace up to 90% of experimental tests, making the enzyme development cost (10-fold lower) and time (cut by 50%) effective. ZYMVOL aims to be the reference in the computer-driven enzyme engineering market and convert molecular modelling in a commodity. In addition to our virtual enzyme sales (we plan to capture €11.17M by 2022 after entering into the North American market), we will promote a royalty-based revenue model from licensing enzymes developed in-house (global enzyme market is projected to reach €9B by 2024). ZYMVOL’s founding team is composed by Maria Fátima Lucas, CEO, Emanuele Monza, CSO and Victor Gil, CTO. All members of the team hold a PhD in chemistry, physics and biomedical engineering. The Company is seeing excellent traction which has allowed it to grown organically in its first 20 months. Thanks to a services-based business model it has already reached breakeven in 2018. The Company has quickly landed some high-profile business and developed a respected reputation by pioneering the access to high resolution computational simulations for all industries.

Keywords: in silico evolutioin silico,computer aided biocatalyst engineering,protein producers,environmentally friendly,green chemistry,cost effective,cloud computing,open source,industry,biotechnology
Nuclear mRNA Packaging and mRNP Architecture (mRNP-PackArt)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-06-01
End date: 2024-05-31
Duration (months): 72.0
Total project cost (EUR): 1991387.5
EU funding (EUR): 1991387.5
Participants: 1
Project status: SIGNED

An important step of gene expression is the formation of a messenger ribonucleoprotein particle (mRNP). The messenger RNA (mRNA) is synthesized by RNA polymerase II transcribing a protein-coding gene. The mRNA is processed, i.e. capped, spliced and polyadenylated, and packaged into an mRNP by binding of RNA-binding proteins (RBPs). The RBPs bound to the mRNA are essential for the stability of the mRNP, control nuclear mRNA export and often determine cytoplasmic processes such as mRNA localization, translation and decay. Thus, the formation and composition of an mRNP is important for the posttranscriptional control of gene expression. Despite its essential nature, the mechanism of nuclear mRNP packaging and the architecture of an mRNP are still poorly understood due to the fact that mRNPs contain many different mRNAs. The overall goal of this proposal is to elucidate the mechanism of mRNP formation and the molecular structure of an mRNP. Specifically, in aim 1, we will determine and quantify the protein composition of a specific mRNP including different stages during its biogenesis, in aim 2, we will illuminate the molecular mechanism of mRNP packaging and in aim 3, we will elucidate the architecture of an mRNP by cross-linking mass spectrometry and electron microscopy. These aims will be achieved by combining novel RNP purification strategies and the powerful biochemistry of the model organism S. cerevisiae to purify a specific mRNP with recent advances in high-end mass spectrometry and electron microscopy. In summary, the expected results of this project will show the architecture of an mRNP in its dynamic nature. mRNP packaging will be understood for the first time on a mechanistic as well as structural level. Thus, the results of this project will break new ground in our understanding of this fundamental cellular process and will also provide insights into how defects in this process lead to disease.

Keywords: nuclear mrnp formation,mrna binding proteins,trex,tho1,nab2,npl3,thsc
Parmesan Cheese Quality Inspection via CAT Scanner and Robotic Arm (PARMESCAN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Italian parmesan cheese, which can only be produced in Italy's Emilia-Romagna and Lombardy provinces, is highly appreciated across the world. However, its expansion is currently hindered by quality and aging issues such as cracks and other defects which appear from handling and storage. The sector has implemented, over the years, a process to assess and control cheese quality in its warehouses (which can contain over 150,000 wheels of cheese, each one weighing 40kg). But this traditional method, based on manual handling, cleaning and regular inspection by trained experts, lacks accuracy, can create more cracks and results in an incorrect cheese grading. This trend is alarming: as it affects directly the acceptance and value of the cheese, producers fail to sell a significant amount of their production, reaching up to 8% in 2015. We are Ing. Ferretti, a 40-year-old Italian company that protects and promotes traditional Italian and EU products through design, manufacturing and sale of automation solutions for the dairy industry. Based on our customers’ concerns, and leveraging our experience in parmesan cheese quality assurance process, we have been developing PARMESCAN, our automated cheese quality inspection system. Combining a robotic arm designed for perfect handling/cleaning of the cheese wheels with CAT imaging technology, our innovative, non-invasive technique will allow producers to fully monitor their cheese maturity and guarantee the seal of authenticity on their products. Not only will our innovation ensure optimum quality grading of this flagship Italian product, but it will also create a simplified and accurate tracking process for every single cheese in a warehouse. We expect PARMESCAN system – starting with parmesan before its expansion to other cheeses and types of food – to consolidate our position as a leading player in the dairy industry and provide us €8 million additional revenues after 5 years of exploitation and a ROI of 280%.

Keywords: parmesan cheese,quality assurance,automation,anthropomorphic robotic arm,computerized axial tomography,cat scan,non invasive,protected designation of origin pdo
Deciphering the effects of locus coeruleus activity on whole-brain dynamics and neurovascular coupling (LC-FMRI)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-01-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

Locus coeruleus (LC) regulates vital autonomous and cognitive functions and has recently gained interest as a clinical target in neurodegenerative and psychiatric disorders. Previous studies have investigated the effect of LC activity on small groups of neurons and on endpoint behavior. However, LC’s widespread connections and broad downstream effects make a systems-level approach imperative for comprehensively understanding LC function. In LC-FMRI, we will perform highly specific optogenetic LC stimulation in mice and assess whole-brain responses and functional network reconfiguration using ultra-high field functional magnetic resonance imaging (fMRI). To decipher neural, astrocytic and vascular contributions to LC-induced fMRI responses, we will acquire simultaneous optical calcium recordings during fMRI. Experiments will be performed in awake mice to circumvent confounding effects of anesthesia on LC function. Finally, we will investigate how LC stimulation affects whole-brain dynamics and neurovascular coupling in the context of sensory processing. Our project will lay the foundation for studying how LC modulates whole-brain dynamics in health and disease using fMRI, with high potential for translation to human applications.

Keywords: opto fmri,ultra high resolution mri,neurovascular coupling,optogenetic,calcium recording
Human Trafficking: A Labor Perspective (HumanTrafficking)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Israel
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-04-01
End date: 2023-03-31
Duration (months): 60.0
Total project cost (EUR): 1492249.99
EU funding (EUR): 1492249.99
Participants: 1
Project status: CLOSED

This project conducts a theoretical, methodological, and normative paradigm shift in the research and analysis of human trafficking, one of the most pressing moral and political challenges of our times. It moves away from the currently predominant approach to trafficking, which focuses on criminal law, border control, and human rights, towards a labor-based approach that targets the structure of labor markets that are prone to severely exploitative labor practices. This shift represents an essential development both in the research of migratory labor practices and in the process of designing more effective, and more just, anti-trafficking measures, that are context-sensitive as well as cognizant to global legal and economic trends. The project will include four main parts: 1) Theoretical: articulating and justifying the proposed shift on trafficking from individual rights and culpabilities to structural labor market realities. 2) Case-studies: conducting a multidisciplinary study of a series of innovative case studies, in which the labor context emerges as a significant factor in the trafficking nexus – bilateral agreements on migration, national regulations of labor standards and recruiters, unionization, and voluntary corporate codes of conduct. The case studies analysis employs the labor paradigm in elucidating the structural conditions that underlie trafficking, reveal a thus-far mostly unrecognized and under-theorized set of anti-trafficking tools. 3) Clinical Laboratory: collaborating with TAUs Workers' Rights clinic to create a legal laboratory in which the potential and limits of the tools examined in the case studies will be tested. 4) Normative: assessing the success of existing strategies and expanding on them to devise innovative tools for a just, practicable, and effective anti-trafficking policy, that can reach significantly more individuals vulnerable to trafficking, by providing them with legal mechanisms for avoiding and resisting exploitation.

Keywords: human trafficking,labor rights,immigration,precarious work,exploitation