Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Accelerated Development of multiple-stress tolerAnt PoTato (ADAPT)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Austria,Spain,Austria,Germany,Belgium,Slovenia,Czechia,Czechia,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Agri-Aqua Labs (H2020-SFS-2019-2, 2019)
Start date: 2020-07-01
End date: 2024-06-30
Duration (months): 48.0
Total project cost (EUR): 4999973.75
EU funding (EUR): 4999972.0
Participants: 17
Project status: SIGNED

ADAPT identifies molecular mechanisms of adaptation to combined stress in potato to develop new strategies for the improvement of productivity, yield stability and product quality under multiple stress conditions. Potato is one of the most important food crops worldwide and a major constraint to secure yield is its sensitivity to environmental stresses, particularly heat and drought, which is often followed by flooding in the field. Whilst limited knowledge of combined stress signalling pathways is available in model plants such as Arabidopsis, this knowledge is almost completely lacking in crops. These adaptation mechanisms require metabolic reprogramming that is triggered by different signalling pathways. To understand the dynamics of complex signalling and response mechanisms our approach will utilise several technological advances (for example high throughput phenotyping and novel sensor plants). These tools will guide us to the key developmental stages and tissues for in depth analysis allowing unprecedented dissection of these processes. The approach requires complementary expertise from 10 leading academic research institutions with 4 major potato breeders, and a screening technology developer. This unique combination of molecular biology, stress physiology, systems biology and analytics with engineering and molecular breeding as well as the active participation of end-user driven agencies for variety testing and potato trading ensure translation of ADAPT results. Arising from our mechanistic understanding, our expected results will include new breeding targets and the potential to match potato varieties to specific environmental conditions. Knowledge from our research will directly reach the most relevant stakeholders and end-users feeding into breeding programmes and guiding technology development for improved crop management strategies. Thus we anticipate that ADAPT will have a game changing impact on potato breeding and management strategies.

Keywords: potato,stress tolerance,abiotic stress,molecular mechanisms,modelling
All-in-one genetic test for fast and accurate diagnosis of the causes of infertility (One4Two)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Infertility is a disorder of the reproductive system which affects 25 million citizens in Europe, preventing them from fulfilling their desire to become a parent. To identify its causes, genetic testing is prescribed to around 35% of the couples under diagnosis, since several factors related to infertility have a genetic origin. However, the effectiveness of infertility genetic analysis and the whole diagnosis process are affected by several issues: an uncomprehensive approach to fertility genetic test, with just a handful of genetic diseases being investigated, each through a dedicated test; a fragmented and cumbersome genetic investigation process that negatively impacts on the couple, adding to the psychological distress caused by infertility, with several batteries of tests often in different laboratories, long diagnosis times and high costs; the lack of a specific genetic testing protocol and diagnosis report for infertility, which increases the workload for laboratories and complicates the diagnosis by gynecologists. KronosDNA has developed One4Two, the first integrated system that provides a comprehensive diagnostic service for the infertile couple, able to cover the whole diagnostic path from lab analysis (through a panel of reagents to analyse DNA through Next Generation Sequencing) to the diagnostic report (by means of a proprietary analysis software). One4Two, with just one blood sample, in 5 days and at an affordable price, provides a complete report on the mutations linked to infertility, probability scores for the transmission of inherited diseases, and the most suitable ART therapies to treat infertility. This is poised to reduce analysis workload, simplify diagnosis by the gynecologist and reduce time to pregnancy. During Phase 1 project, the system will be optimized with end-users to prepare the ground for the required certifications, upscaling and commercialization, by also consolidating the business model, the marketing strategy and the pricing.

Keywords: infertility,dna analysis,next generation sequencing
Double Incremental Expansion in Potential Energies from Automized Computational Exploration (DIEinPEACE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Modern computational methods of quantum chemistry are valuable and well-established tools for interpretations, refinements, and even predictions of experimental results. Recent advances within linear-scaling (with the system size) approaches allowed routine and efficient treatments of electronic structures of much larger molecular systems than those accessible in previous decades. This has the potential to extend the applicability of quantum chemistry to very large biomolecules. However, reaching a close to linear-scaling behavior for a single point calculation is by no means near to providing an efficient description of the total potential energy surface. Because potential energy surfaces are cornerstones for obtaining a detailed knowledge of reactivity, photochemical properties, vibrational motion, etc., development of a computationally inexpensive but accurate quantum chemical methodology for potential energy surface calculations of large biomolecules (such as proteins) is of extreme importance for chemical science. The proposed project aims at filling this gap by developing an ab initio, linear-scaling, and "black-box" machinery for protein potential energy surfaces calculations, where the linear-scaling refers to the total computational cost. This will be achieved by combining ideas of partitioning the total system into subsystems and incremental expansions of potential energy surfaces with efficient and accurate computational algorithms and modern concepts of machine leaning. The proposed strategy will enable theoretical spectra simulations for much larger biomolecules. This will significantly advance the current stage of the field and help to reveal many new and intricate details about structures and dynamics of proteins.

Keywords: theoretical method development,potential energy surface,ab initio methods,incremental,many body expansion,density based embedding,gaussian process regression
Enhancing the innovation management capacity of the SMEs in Central Poland-2 (KAM2CentralPoland-2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Poland,Poland,Poland,Poland
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 189362.5
EU funding (EUR): 189362.5
Participants: 6
Project status: CLOSED

The KAM2CentralPoland-2 project will be implemented by the consortium called EEN-CP in central parts of Poland. The main objective of the project is to increase the efficiency and the effectiveness of R&D and innovation investments that will contribute to smart growth in EU countries. Main objective of the project will be implemented via two specific objectives: 1.To provide higher quality innovation support services to small and medium enterprises where those are absent or offered at unaffordable market prices. This objective will be implemented by a specially designed activity called Enhancing the innovation management capacity of SMEs (EIMC), addressed to SMEs with a real potential for international growth via product, process, service or business model innovation but lack the knowledge, skills or ability to manage innovation activities; 2.To ensure that the SME Instrument beneficiaries receive the most appropriate services to enhance the probability of successful exploitation of the innovation project supported by the Instrument and to leave a footprint for the future sustainable growth of the beneficiary by identifying bottlenecks and indicated solutions with the help of a capable coach. This objective will be implemented by the tailor made service of The Key Account Management (KAM). There are measures within the structural funds dedicated to the SME sector that support elements of innovation management but the mentoring and coaching schemes still needs to be improved. Thus, both services the KAM and the EIMC offered under this proposal address the challenges described in the Article 10 of the COSME regulation as well as it meets the requirements of the specific activities in the context of innovation support described in the Terms of Reference of the Consultation of Enterprise Europe Network partners on the work programme for 2017-2018 H-2020 activities (H2020-EEN-SGA2-2017-2018).

Keywords: enhancing innovation managment capacity,horizon2020,key account manager,h2020
Diophantine Geometry: towards the ultimate Bogomolov conjecture (DiophGeo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

This project proposes research with a view towards extensions of the Bogomolov conjecture beyond the original setting of abelian varieties. In the past decade, there have been some indications that this may be possible: (a) Masser and Zannier have proven "relative'' analogues of the Manin-Mumford conjecture in various families of abelian varieties, (b) DeMarco and Mavraki have shown a "relative'' analogue of the Bogomolov conjecture for sections in a fibered product of elliptic families, and (c) Ghioca, Nguyen, and Ye have proven a "dynamical'' Bogomolov conjecture for split rational maps. A prominent tool in almost all proofs of the Bogomolov conjecture are equidistribution techniques (i.e., Yuan's equidistribution theorem). However, there are two problems with this approach when it comes to "relative'' generalizations. First, the Néron-Tate local height in families of abelian varieties exhibits b-singularities nearby degenerate fibers, preventing a direct use of Yuan's theorem if the family has degenerate fibers. Recently, I have overcome these problems and proven a satisfactory analogue of the equidistribution conjecture in families of abelian varieties over a base curve. Part of the research proposed here is to generalize and exploit this result further. Second, equidistribution techniques usually fall short of "relative'' Bogomolov-type results -- in stark contrast to the case of abelian varieties. Similar problems arise in the "dynamical" setting, indicating a profound conceptional obstacle. For this reason, it is proposed here to adapt a method of David and Philippon, who gave an equidistribution-free direct proof of the Bogomolov conjecture for abelian varieties, to the relative setting. Such a method, if successful, should shed some light on an "ultimate'' Bogomolov conjecture encompassing virtually all the Bogomolov-type results known up to the present day.

Keywords: diophantine geometry,abelian varieties,bogomolov conjecture,equidistribution,arakelov theory,arithmetic dynamics
Decentralizing Conceptual Art's Internationalism: Latin American artists in Western Europe, 1968-1979 (COART-INT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2023-05-31
Duration (months): 36.0
Total project cost (EUR): 281358.72
EU funding (EUR): 281358.72
Participants: 1
Project status: CLOSED

My proposed project problematizes Conceptual art’s internationalism and its historicization with an innovative study on transnational artists who expatriated from Latin American repressive political regimes to Europe, establishing themselves in Belgium, England and the Netherlands between 1968-1979. The objective is to assert these artists as agents of transcultural processes and their conceptual practices as operating within a dynamic matrix that is at once local and international, deterritorialized and rooted. Through an analysis of unique data collection, oral history and artworks this research aims to fundamentally revise the art historical canon by de-centering the major narrative of Conceptual art of the 1960s and 70s to comprehensively address the prominent roles these artists had on their adopted localities, a Latin American diasporic art world and the formulation of internationalism. By focusing on the interstitial spatial regimes these artists occupied and created, this research effectively redraws the discipline’s original topography and conventional analyses fixed within national paradigms towards a logic of transnationalism fueled by the mobility of agents, objects and practices. In the example of this project, a transnational methodology reassesses regional art histories — Belgian, Dutch, English and Latin American — to capture interregional flows and networks of production. Furthermore, it underscores a present condition in which geographical and cultural borders are increasingly more connected. The topic is timely in regards to the evolving understanding of Conceptual art. More specifically, the issues of exile, mobility, internationalism and localism that figure into this work offer a unique case study into Conceptual art’s role in driving and defining a “global” condition that is relevant today and more specifically art’s “global contemporary”, also referred to as “new internationalism of contemporary art.”

Keywords: conceptual art,contemporary art,neo avant garde,internationalism,latin america,europe
Pharmacological inhibition of macrophage activation (FIREQUENCHER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2021-01-01
End date: 2022-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Macrophages are innate immune cells that specialise in sensing and responding to the presence of pathogens and they have been causally involved in the pathogenesis of both sepsis and rheumatoid arthritis (RA). Both diseases represent a high cost to the economy and society of European countries characterized by an aging population as well as developing countries. Sepsis is the first cause of death in hospitalized patient, with an estimate of 5 million deaths each year. Currently, there are no effective treatment protocols or strategies to deal with sepsis and several approaches targeting known cellular pathways have failed. RA is a chronic condition that affects 1% of the population worldwide. Despite the existence of established guidelines, 66% of patient inadequately respond to the therapy. Our group discovered that DNA damage is involved in the control of macrophages activation, unveiling a novel and untapped pathway potentially ripe for new approaches to modulate their activity. Thus, our proposed project is to test drugs targeting factors involved in DNA metabolism to treat inflammatory immune disease. Our plan involves a first part using an in vitro strategy to test the efficacy of the inhibitors on different macrophages cell lines and a second part involving the use of well-established animal disease models.

Keywords: sepsis,rheumatoid arthritis,inflammation response,dna repair,dna damage response,enhancer transcription
Impact of NMDA receptor diversity in sensory information processing (SensoNMDA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-12-01
End date: 2021-11-30
Duration (months): 60.0
Total project cost (EUR): 1200000.0
EU funding (EUR): 1200000.0
Participants: 1
Project status: CLOSED

Synaptic variability between neuronal connections is thought to contribute to brain’s remarkable information processing capacities. In the adult brain, the density as well as subunit composition of synaptic NMDA receptors (NMDARs) varies considerably between synapses and between neurons. Despite the well documented heterogeneity of NMDARs the functional relevance of such diversity is poorly known. In the past, the functional relevance of such NMDAR diversity has been mostly considered in the context of neuronal development and long-term synaptic plasticity. Model simulations have highlighted that dendritic computations are strongly influenced by synaptic NMDARs densities and biophysical properties. Here I propose to directly study the consequence of NMDAR diversity in shaping integration properties of single neurons in primary somatosensory cortex (S1). To achieve this I will decompose this broad question into three specific tasks. 1-Assessment of NMDAR heterogeneity in glutamatergic neurons and study how this variability shapes dendritic integration. 2-Study the impact of NMDARs in signal computation among cortical interneurons. 3-Investigate the functional relationship between endogenous NMDAR modulators and NMDAR diversity. I plan to use an array of genetic, optogenetic and pharmacological tools in combination with imaging and electrophysiological techniques to achieve the proposed objectives. Importantly, in vivo electrophysiology and two-photon imaging will be used to assess the functional relevance of NMDARs heterogeneity in single neuron computational strategies during sensory stimulation. I expect to reveal that NMDAR diversity plays a fundamental role in sensory information processing by tuning the relative recruitment of inhibitory and excitatory neurons during sensory stimuli. This work will provide an original and important data set demonstrating how NMDARs diversity provides cortical neurons with the possibility to compute complex sensory information.

Keywords: dendritic integration,nmda receptors,sensory information
Supporting Internet of Things Activities on Innovation Ecosystems (UNIFY-IoT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Italy,Italy,Germany,Norway,France,France,United Kingdom
Call: Internet of Things and Platforms for Connected Smart Objects (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2018-03-31
Duration (months): 27.0
Total project cost (EUR): 1013185.0
EU funding (EUR): 1000000.0
Participants: 9
Project status: CLOSED

Coordination and Support Action to stimulate the collaboration between IoT projects, between the potential IoT platforms and support these in sustaining the IoT ecosystems developed by focusing on complementary actions, e.g., fostering and stimulating acceptance of IoT technology as well as the means to understand and overcome obstacles for deployment and value creation.

Keywords: internet of things,cyber physical systems,platforms,iot ecosystems,innovation