Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Decoupled Covalent Dynamic Exchange Reactions for Closed-Loop Photo-3D-printing (DeCoDER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1499901.0
EU funding (EUR): 1499901.0
Participants: 1
Project status: SIGNED

As global dependence on synthetic materials is intensifying, waste-accumulation of end-of-life products has become a major concern. Specifically fast-growing 3D photo-printing technologies present a major challenge as a liquid ink is transformed into a permanently hardened crosslinked photo-polymer that can no longer be recycled. Current photochemical processes that underpin light-based 3D printing processes, however, fail to address the urgently needed closed loop recycling of the resulting 3D materials. Indeed, a fundamental step-change in the underlying, persistently used, chemical technology is urgently needed for 3D printed waste to be effectively and completely depolymerised into the same functional photo-ink for it to be intrinsically re-used in 3D-re-printing. Here, an innovative concept is proposed that offers a ground-breaking solution to the problematic interplay of existing bond exchange reactions currently used in dynamic covalent networks, including 3D printed vitrimers. The idea relies on decoupling the underlying chemical equilibrium by independently regulating bond formation with light, and bond-breaking by temperature. For this, decoupled covalent dynamic exchange reactions (DeCoDERs) will be developed that show selective and sustained covalent bonding/debonding over multiple cycles. The novel DeCoDER systems will be transformed into functional platform building blocks through scalable protocols, allowing for their introduction into dynamic polymer materials. After evaluating the effect of consecutive de- and re-crosslinking of the equilibrium-decoupled material properties, the derived insights will be used to validate the proposed conceptual approach in light-based additive manufacturing. Specifically, a very first 3D photo-print-to-reprint technology will be devised with full recyclability of photo-printed objects into the same initial liquid photo-ink without needing additional chemicals, thereby enabling a direct, truly closed-loop re-print.

Keywords: dynamic covalent chemistry,photocycloadditions,photo switchable materials,3d photo printing
Unveiling Syedra: Archaeogenomic insights into an Anatolian coastal city during the Roman-Byzantine transition (SyedArcGen)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 2
Project status: SIGNED

The transition from Roman to Byzantine rule in Anatolia brought significant sociopolitical and cultural transformations, particularly in coastal cities such as Syedra, located on the southern coast of modern-day Turkiye. Syedra prospered as a thriving urban centre during the Roman era and retained its importance under Byzantine rule. However, despite extensive archaeological research, the impact of this transition on the Syedra community hitherto has not been explored through archaeogenomics. To address this gap, I aim to conduct an archaeogenomic study of human remains from Syedra, spanning the Roman and Byzantine periods. By generating and analysing ancient genomic data, I will investigate the impact of this transition on the population dynamics, health status, and social structure of the Syedra community. By integrating archaeogenomic methods with interdisciplinary datasets and leveraging an international network of collaborations, this research will offer a comprehensive understanding of the Syedra community during the Roman-Byzantine transition. As the first study to focus on an Anatolian coastal community during this pivotal period, it will be of great importance and will also provide novel insights into the broader eastern Mediterranean. Combining my solid track record in ancient human genomics, and the host institution’s expertise in ancient DNA and metagenomics, this fellowship will enable me to develop the key skills to establish myself as a research leader in archaeogenomics and make significant contributions to the field.

Keywords: syedra,archaeogenomics,metagenomics,health,kinship,population dynamics,whole genome data,roman byzantine transition,anatolia
QUANTUM-ENHANCED BENCHTOP NMR SPECTROMETER (QUENCH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Israel,Czechia
Call: Next generation quantum sensing and metrology technologies (RIA) (HORIZON-CL4-2023-DIGITAL-EMERGING-01-CNECT, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2556603.75
EU funding (EUR): 2556603.75
Participants: 7
Project status: SIGNED

Nuclear magnetic resonance (NMR) spectroscopy is the workhorse of modern molecular structural analysis with countless scientific applications, from materials science to drug discovery. Nevertheless, even the most modern NMR spectrometers still employ the same principles as 80 years ago, induction coils and high magnetic fields, making them bulky, expensive, and inaccessible to many potential users. However, a novel type of NMR sensor emerged recently from solid-state spin quantum systems: the nitrogen-vacancy (NV) center in diamond, which has demonstrated unparalleled sensitivities in detecting NMR signals. In this proposal, we aim to significantly enhance the sensitivity of modern benchtop NMR spectrometers by several orders of magnitude. We will achieve this improvement by combining the NMR technology field with cutting-edge quantum sensing, employing improved NV-diamond materials, advanced microwave antennas, novel pulse sequences, and quantum control protocols. The goal is to achieve complete control and protection from the environmental noise of the NV-spin state, incorporating quantum memories and logical operations to reach radiofrequency sensitivities well beyond those of classical NMR sensors. The quantum-enhanced benchtop NMR spectrometer will be applied and validated in an analytical chemistry lab environment to demonstrate record sensitivities in molecular analysis enabled by quantum technology, with potential applications in quality control, environmental monitoring, medical diagnostics, online monitoring of chemical reactors, and materials discovery.

Keywords: quantum sensing,nitrogen vacancy center,diamond,chemical analysis,nuclear magnetic resonance
INNOVATIVE DECISION-MAKING TOOL FOR DEFINING THE MOST SUITABLE MANURE MANAGEMENT STRATEGIES TO ACHIEVE A SUSTAINABLE LIVESTOCK FARMING SYSTEM DURING THE WHOLE VALUE CHAIN (NUTRITIVE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Spain,France,Belgium,Italy,Ireland,China,Germany,Netherlands,Portugal
Call: Optimisation of manure use along the management chain to mitigate GHG emissions and minimize nutrients/contaminants dispersion in the environment (HORIZON-CL6-2023-ZEROPOLLUTION-02, 2023)
Start date: 2024-06-01
End date: 2028-05-31
Duration (months): 48.0
Total project cost (EUR): 6996507.5
EU funding (EUR): 6996507.5
Participants: 22
Project status: SIGNED

Livestock farming is a key sector that involves 40 % of the total agricultural activity in Europe. representing a total value for products equal to € 170 billion. However, there is an increasing concern due to livestock farming’s contribution to environmental pollution since it generates more than 1.4 billion tonnes/year of manure leading to significant greenhouse gases (GHG) and air pollutants emissions(NH3, NOX)as well as to soil and water contamination caused by hazardous manure chemicals and biological contaminants (called here emerging contaminants). In this context extensive effort has been carried out for years to assess the detrimental effects of farming systems and to develop abatement methods to be implemented. However, despite major advancements, many fundamental issues are beyond the scope of existing legislation. The main objective of NUTRITIVE is to develop a decision-making tool (DSS, decision support system) able to define the most efficient and sustainable (in its three pillars: environmental, economic, and social) manure management strategies for a given livestock farm limiting manure air emissions as well as soil and water contaminants. This will allow for the formulation of technical guidelines and recommendations that will support policy makers with enhanced knowledge to establish requirements for future European policies. To fulfill this objective, the project is divided into six work packages (WP): WP1 Up-to-date inventory; WP2 Novel management strategies/technologies investigation; WP3 Modelling and LCA; and WP4 Guidelines formulation; WP5 Communication, dissemination, and exploitation; WP6 Management. NUTRITIVE anticipates a wide spread of the project outcomes, with the synthesis of the consortium as a baseline: 22 partners (4 Chinese) from 8 different countries across Europe, covering 6 climatic regions (2 Chinese ones), representing the whole supply chain experts, from animal feed to soil application.

Keywords: circular farm model cost benefit analysis decission making tool digital twins fate models life cycle assessment policy recommendations
THE PATIENT LED COMMONIFICATION OF HEALTHCARE?’ the case of DIY-Diabetes: an ethnographic Study (COMMONS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland,Canada,Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2026-12-31
Duration (months): 40.0
Total project cost (EUR): 269915.04
EU funding (EUR): 269915.04
Participants: 3
Project status: SIGNED

The aim of this project is to examine how commons-based peer production is impacting healthcare ecosystem dynamics and the lived experience of people with diabetes (PwD). The project focuses on communities of PwD who, collaborating online via open-source forms of knowledge exchange, are increasingly empowered to create and modify diabetes technologies to better meet their medical needs. Since its emergence in 2013, this patient-led commons has produced a range of innovations that can help improve clinical outcomes and quality-of-life. However, these innovations sit outside of commercial and regulatory processes and create dilemmas for healthcare professionals, regulators and industry. Furthermore, the central role of technology in this community has raised questions about who can participate in and benefit from its innovations. Through in-depth interviews and ethnographic observations, this project aims to capture the understandings of key stakeholders as to how and why the patient-led commons came to be as well as their visions of its role in the future of diabetes care. It ill shed light on how patient-led innovation is potentially transforming the development and diffusion of healthcare technologies and the implications of this for equity in healthcare outcomes. It is anticipated that the findings will help decision-makers to determine what sort of collaborations or partnerships can be developed between the patient-led commons and established ecosystem players to address the needs of PwD and other chronic conditions. The project includes a training programme supported by an international team of prominent scholars in science and technology studies and will provide opportunities for learning and networking that will help consolidate the Fellow as an emerging leader in patient-oriented research. Overall, the Fellowship alligns with the EC’s commitment to the inducement, uptake and scaling-up of social innovation in Europe as well as 3,5&8 of the UN SDGs.

Keywords: patient led innovation,qualitative
Targeting Cardiovascular Disease with Microbiota-derived Bioactive Compounds (DIETherapy)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 236340.0
EU funding (EUR): 236340.0
Participants: 1
Project status: SIGNED

Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, although advancements in glucose-lowering, weight-reducing, and lipid-lowering therapies. Emerging evidence suggests that the gut microbiome and its metabolites are critically involved in the pathogenesis of various metabolic disorders contributing to CVDs, including obesity and type 2 diabetes, and also play a direct role in CVD development. Conversely, other reported microbiome-derived compounds appear to be beneficial for the host, exhibiting antioxidant and anti-inflammatory properties. This project aims to explore the therapeutic potential of microbiota-derived polyphenols in modulating the immune system to prevent and treat CVDs. Specifically, this proposal seeks to identify polyphenolic metabolites associated with a reduced risk of atherosclerosis development and to assess their immunomodulatory and protective effects in murine models. Aim 1 will involve bioinformatic analyses of a large human cohort with comprehensive microbiome and metabolome data to identify polyphenolic candidates associated with a lower risk of atherosclerosis. Aim 2 will explore the capacity of these polyphenols to induce long-term anti-inflammatory phenotypes through epigenetic and transcriptomic reprogramming in human and murine innate immune cells (trained immunity). The therapeutic efficacy of these polyphenols will be further evaluated in murine models of atherosclerosis and chronic inflammation, with a focus on elucidating the underlying molecular mechanisms. The methodologies employed will include advanced bioinformatics, in vitro immune cell assays, and in vivo murine studies, including microbiota and metabolome profiling. This interdisciplinary approach, combining human clinical data with mechanistic studies in mice, is expected to provide new insights into the role of microbiota-derived polyphenols in CVD prevention and treatment, potentially leading to novel therapeutic interventions.

Keywords: atherosclerosis,microbiota derived metabolite,polyphenol,trained immunity,innate immune memory,therapy,microbiota
ApTOLL: An innovative neuroprotectant to reduce brain damage in Acute Ischemic Stroke (AIS) (ApTOLL)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-01-01
End date: 2026-03-31
Duration (months): 27.0
Total project cost (EUR): 3569737.25
EU funding (EUR): 2498816.0
Participants: 1
Project status: SIGNED

Stroke is a devastating medical condition affecting 15 million people worldwide yearly, being Ischemic Stroke the most frequent (87%). Indeed, the global cost of stroke is >€847b (≈€60b in EU) due to the huge socioeconomic burden of disabilities. Reperfusion treatment improves outcomes, but only ≈20% of patients are currently eligible for treatment due to the narrow therapeutic window after stroke symptom onset and stringent selection criteria for eligibility. Novel therapies - small molecules or biologics - targeting neuroprotection have not achieved enough efficacy to get approved. aptaTargets has successfully developed ApTOLL, an immune modulator and neuroprotectant with a novel approach TO REDUCE BRAIN DAMAGE in AIS patients. aptaTargets’ ApTOLL drug has a novel approach targeting TLR4 to reduce brain damage in acute ischemic stroke (AIS) patients (47% reduction of FIV), reduce mortality from 18% to 4% and improve functional outcomes. Due to the innovative MODE OF ACTION AND NATURE of the molecule (an aptamer), ApTOLL represents a novel and disruptive approach to treating stroke in the first hours after the onset (acute phase), substantially reducing brain damage and improving Quality of Life (QoL) in short and long time. ApTOLL is targeting the Multi-Billion Market of the global Stroke Management Market, valued at €31.7Bn in 2020 and expected to reach €67.7Bn in 2030 (7.8% CAGR). As a first indication within the scope of this EIC Accelerator proposal, ApTOLL will target AIS patients (87%) who received EVT therapy, expecting to be potentially used as neuroprotectant in all stroke patients, based on preclinical and clinical results. The EIC project aims to conduct the Ph2b trial of ApTOLL and demonstrate its efficacy before entering Ph3. It will boost our chances of licencing the product to a pharma company, increasing the value of the agreement.

Keywords: acute ischemic stroke,neuroprotection,aptamer,therapy,tlr4 receptor,brain damage,clinical trial,stroke,aptoll,inflammation,oligonucleotides,neurology,neurovascular,drug development,health
Powering Tomorrow with the Next-Gen Thorium Molten Salt Reactors to Burn Nuclear Waste (Th-MSR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator Open 2025 (HORIZON-EIC-2025-ACCELERATOR-02, 2025)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

The global energy demand is set to surge by 62-185% by 2050, driven by population growth and economic expansion. Despite being responsible for a staggering 75% of global greenhouse gas emissions, fossil fuels are projected to dominate the energy mix until 2050. Our generation faces a crucial challenge in finding large-scale alternatives to fossil fuels that are affordable, safe, and sustainable. Nuclear energy is instrumental in achieving these ambitions. It is a low-carbon energy source, emitting the lowest amount of CO2/kWh considering total life-cycle emissions of all energy sources. Copenhagen Atomics is developing breakthrough nuclear technology to enable a paradigm shift for green energy. We are pioneering thorium molten salt reactors (Th-MSRs), the Waste Burners, – a groundbreaking solution that burns nuclear waste to generate abundant and cost-effective energy. This next-generation reactor is engineered for faster construction, lower deployment costs, and reduced environmental impact compared to traditional reactors. The Waste Burner fits inside a custom-built 40-foot shipping container and can be mass-manufactured on assembly lines with an expected output of 1 reactor per day (per assembly line) once scale-up has been achieved. Additionally, the waste left behind by the CA reactor only needs to be stored for 300 years above ground, vs. 100,000 years of expensive deep geological storage. The unique value proposition points emphasize industry-leading LCoE €20 per MWh in the mass production stage, lowest all-in CO2 emissions, mass manufacturing feasibility, waste reduction, and walk-away safety. This positions us as potentially the most affordable green electricity source in the 2030s. The Waste Burner presents a disruptive and sustainable alternative to fossil fuel-based energy, contributing to the decarbonisation of energy systems, reducing Europe's dependence on fossil fuels, and providing affordable, secure and sustainable energy for Europe.

Keywords: advanced nuclear small modular reactor nuclear physics autonomous operation molten salt reactor
AUTOMATED, USER-FRIENDLY SYSTEM FOR REUSABLE PACKAGING MANAGEMENT (SmartCycle)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Estonia
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2390000.0
EU funding (EUR): 2390000.0
Participants: 1
Project status: SIGNED

A major source of plastic pollution is single-use packaging. Every year, over 500 billion single-use plastic cups are used globally. Currently, 12% of this amount is incinerated; the rest accumulates in landfills, is dumped, or dispersed into marine and other environments. Plastic pollution, including microplastics, particularly threatens the marine environment due to its transboundary nature. The move away from single-use plastics is a critical environmental initiative, but completely abandoning reusable plastics isn't yet feasible due to the absence of suitable alternatives in many applications. Reusable plastics continue to be essential for their durability, efficiency, and consumer convenience, especially in sectors where alternatives do not match their functionality or are not widely accessible. The transition to a plastic-free environment is complex, involving considerations of current technological capabilities, infrastructure for recycling, and the development of viable, sustainable alternatives. The key, therefore, lies in the responsible use and management of reusable plastics, alongside persistent efforts to innovate and develop more sustainable materials for future use. The Estonian company Cuploop has developed an AUTOMATED, USER-FRIENDLY SYSTEM FOR REUSABLE PACKAGING MANAGEMENT based on radio-frequency identification (RFID) and near-field communication. The solution offers a seamless consumer experience and aims to solve most problems of the currently used packaging reuse systems, making this process highly scalable. The system is designed to meet the expectations of the Digital Product Passport architecture and can be extended to various other industries as well.

Keywords: plastic pollution,reusable packaging,digital product passport,waste management,sustainable development,smart city,environment protection