Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Perceive, the first hardware-agnostic brain-sensing solution to enable brain control of devices through earphones (Perceive)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2290000.0
EU funding (EUR): 2290000.0
Participants: 1
Project status: SIGNED

Perceive is a human machine interface allowing users to control their devices through brain and facial activities. Wisear main goal is bringing humans and computers closer than ever before and making this technology accessible to millions of people through everyday products, and not some fancy equipment that you can only find in labs. Five years from now, we believe most of our everyday devices will be equipped with biosensing solutions, and we plan on being the biometric technology for brain & muscle neuronal activity on every wearable device, giving people valuable insights & seamless controls over these devices. The company operates in the field of neurotechnology a nascent technology with proven medical benefits and had recently been made more accessible by improvements in electronics and data science.

Keywords: human machine interface neurotechnology neural interfaces ai based biosignal control
AI-driven wearable neurostimulation to restore mobility and prevent disability across Europe (NERVEAIDE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 1300000.0
EU funding (EUR): 1300000.0
Participants: 1
Project status: CLOSED

NERVEAIDE develops AI-powered wearable neurostimulation to restore mobility and hand function in people with neurological and age-related movement disorders. The project scales EU production of a clinically validated, affordable device family for everyday use at home, work, and in clinics. Having mass-produced and shipped 5,000+ units, we will relocate and upgrade the technology for EU compliance, offering a more effective and lower-cost complement to conventional rehabilitation. Objectives: (1) complete EU conformity assessment and reach TRL 8–9; (2) industrialise manufacturing to cut unit cost and raise reliability; (3) generate clinical and health-economic evidence for adoption and reimbursement; (4) launch in initial EU markets. By M6 we will finalise the bulk of IEC/EMC, software lifecycle, usability, risk, biocompatibility and cybersecurity evidence; by M16 get all necessary certificates for EU launch and by M24 deliver first launches. How: We combine motion sensors with closed-loop functional electrical stimulation and adaptive AI to deliver therapy that adjusts to each user in real time. The sensors track movement and feed data to the AI, which continuously tunes stimulation patterns so the device stays effective as the user’s motion changes. This produces personalised, consistent assistance during everyday activities without manual re-programming. Relevance: This deep-tech, market-creating solution aligns with EU priorities on healthy ageing and digital health. We aim to expand across all EU countries to help millions of people with neurological conditions and seniors avoid disability. By enabling remote therapy (tele-rehabilitation), we reduce travel time and costs for patients and families, and improve clinicians’ efficiency through continuous monitoring and data-driven care.

Keywords: ai in health,wearable neurostimulation,rehabilitation,mobility restoration,gait improvement,upper limb function,fes,stroke,multiple sclerosis,elderly care,ce mdr,eu scale up
Targeting Alimentary Systems in TBEV Experimentation (TASTE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia
Call: ERA Fellowships (HORIZON-WIDERA-2024-TALENTS-02, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 191918.16
EU funding (EUR): 191918.16
Participants: 1
Project status: SIGNED

Tick-borne encephalitis virus (TBEV) has an estimated mortality rate of up to 40%, and although transmission is primarily associated with tick bites, a secondary route is that of alimentary transmission. Alimentary transmission occurs through the ingestion of contaminated ‘raw’ dairy products. Since its discovery in the early 1950’s the incidence of TBEV due to this infection method has continuously increased, currently accounting for ~1% of all TBEV cases. Despite this, the alimentary route of infection is severely understudied, and there are no defined mechanisms by which TBEV breaches the intestinal epithelial barrier and disseminates to secondary tissues. To address this gap in knowledge, the TASTE (Targeting Alimentary Systems in TBEV Experimentation) project aims to elucidate the key molecular interactions (both extra- and intracellular) and examine these factors in a cellular and tissue context to establish a model for TBEV alimentary infection. A novel crosslinking immunoprecipitation pipeline will be developed, utilising the incorporation of photosensitive unnatural amino acids into the TBEV genome, to identify the host receptors responsible for virus binding and internalisation. RNA interactome capture and immunoprecipitation will be used to isolate the intracellular factors responsible for viral replication. Following this, the importance of these components and the influence of additional environmental factors will be examined in both cell culture and tissue models. The output of this project will not only be informative to the mechanisms of alimentary infection but will serve as a foundation for future research into therapeutics and patient treatment. I chose to pursue this project within the Ruzek lab at MUNI, as this lab excels in TBEV research and has all the resources necessary to achieve this work. By adding my expertise in molecular virology, we aim to develop novel angles in TBEV research from which future projects can be developed.

Keywords: tick borne encephalitis,alimentary transmission,molecular virology,host virus interactions,intestinal epithelial barrier model,viral kinetics,host receptors,immunoprecipitation,rna interactome
10X MOST ADVANCED FLEXIBLE AND DIVERSELY FIREPROOF COMPOSITE (FCT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Georgia
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2490000.0
EU funding (EUR): 2490000.0
Participants: 1
Project status: SIGNED

Fireproof Composite Technologies (FCT) focuses on advancing the safety of electric vehicles (EVs) by addressing critical fire hazards in lithium-ion batteries. Globally, the rise of EVs brings forth the challenge of ensuring battery safety, especially regarding fire risks. FCT's innovation is the most advanced and revolutionary fire-resistant composite material (patent pending), that has the capacity to resist 2000º degrees during a period of 30 minutes. The composite is primarily developed to enhance battery safety, effectively protecting against fire risks and thermal runaways. This innovation is particularly significant, considering lithium batteries' high cost and safety concerns. FCT's material not only demonstrates superior fire resistance and is capable of withstanding extreme temperatures but also offers flexibility and is lightweight, making it adaptable for any EV´s lithium battery type and future car elements. The benefits extend beyond safety, including improved battery performance in extreme temperatures and alignment with evolving safety standards. Our vision at FCT includes a phased approach to entering the market. Initially, we focus on lithium batteries in EVs, with plans to expand to other car components and eventually to industries like aerospace and maritime. Our strategy is to influence regulatory standards to align with our advanced fireproofing capabilities, positioning ourselves as leaders in fireproof composites. Our innovative material enhances safety while providing flexibility and lightweight features, which are essential for the automotive industry. Our balanced approach of innovation and practicality positions us to reshape safety standards and drive significant changes in EV battery safety.

Keywords: materials engineering electrochemistry,batteries and fuel cells,thermodynamics,graphene,layered materials,process engineering
Pioneering Unprecedented Life-Saving Equipment: Intelligent Aortic Balloon Catheter for Cardiac Arrest (PULSE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

With a worldwide incidence expected to increase from 9 million cases in 2023 to 11 million cases by 2030, cardiac arrest is a public health crisis with a survival rate at only around 10% and a high degree of brain damage among the few survivors. Defibrillators cannot be used in 76% of cardiac arrest patients due to a non-shockable rhythm, leading to an extremely low survival-to-discharge for these patients (3.3%). Neurescue Aps (NEUR) addresses the cardiac arrest burden by bringing to market a game-changing solution – the Neurescue device – the world's first intelligent fluoroscopy-free aortic balloon catheter. By combining unique proprietary features including 1) an intelligent system for automated balloon inflation and deflation managed by the controller component, coupled with 2) precise positioning feedback from the patented sensor system in the catheter, these together provide a safe computer-controlled aortic balloon occlusion for use both inside and outside hospital settings. The Neurescue device increases blood flow to the heart and brain, which makes the patient more likely to respond to resuscitation efforts. This also increases the likelihood of bridging patients to definitive therapies, extending the critical time window from the current 20-30 min to ~60 min. This is especially valuable in patients with a non-shockable rhythm for whom the standard of care (SoC) results in extremely low survival (3.3%). The use of the Neurescue device, both inside and outside hospitals, is expected to increase the survival rate of cardiac patients by up to 40% - thereby holding the potential to save millions of lives. The Neurescue device is projected to be ready for commercial roll-out by 2027 reaching €931.37M in revenues by 2033. The PULSE project aims to surpass the main market barriers associated with the market introduction of the Neurescue device, namely gathering data for a CE mark and clinical validation to ensure end-user adoption

Keywords: cardiac arrest,advanced life support,computer controlled aortic occlusion,vital organs preservation
REsolving ambiguities in Flow boiling within micro-passages: Integrated modeliNg and Experiments (REFINE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Portugal
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 172618.56
EU funding (EUR): 172618.56
Participants: 1
Project status: CLOSED

Electronic products are progressively smaller and more powerful, resulting to an exponential increase in the generated residual heat. Their effective and environmental-friendly cooling is therefore, of upmost importance for many applications such as Data Centres, Fuel Cells, Insulated-Gate Bipolar Transistors, Lithium-Ion Batteries and Photovoltaic Cells, with a market value of several billions of dollars worldwide. Flow Boiling within micro-passages has been proven as one of the most efficient cooling strategies for such High-Power Density Electronics. However, such solutions, are not yet commercially available. This is due to a lack of a deep understanding of the underpinned flow and transport processes and unresolved ambiguities in micro-scales and hence, of reliable and easy-to-use thermal design tools for small-scale components. REFINE aims to give light at such crucial ambiguities, utilising a synergic combination of novel Volume Of Fluid (VOF) based numerical simulations and tailored high-resolution experimental diagnostics. Dr Andredaki will develop a novel cutting-edge simulation tool starting from an already enhanced VOF solver that she has been developing in the last years. This will be validated against parallel advanced experimental measurements on flow boiling, that she will perform using single and multiple parallel micro-channel heat sinks. The final optimised and validated numerical solver will then be applied for a wide series of parametric simulations that in combination with additional laboratory measurements will form a unique database that will lead to the development of novel, physics-based design correlations for flow boiling micro-channel heat sinks. The word-leading expertise of Prof. Moreira, who will supervise this project, on the experimental techniques for microscale boiling, guarantees the highest level of knowledge transfer, enabling Dr Andredaki to further develop her skills and enhance her future career opportunities in academia.

Keywords: flow boiling,phase change heat transfer,micro channel heat sinks,numerical simulations,volume of fluid method,spatiotemporally resolved experimental diagnostics
Deciphering the role of host immunity in development of herpes virus meningitis (Divir)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: CLOSED

Viral infection remains a major health burden globally, particularly considering the recent emerging viruses. The reason why individuals differ in susceptibility to viral infection is an essential, still unresolved question, in infection immunology research. The answer has strong impact on understanding of fundamental immunological principles as well as clinical medicine. In this project, we aim to identify novel inborn errors of immunity conferring increased susceptibility to recurrent lymphocytic Mollaret’s meningitis caused by herpes simplex virus 2. By using advanced methodological approaches, including whole exome sequencing, genome editing and disease-mimicking model systems, we will search for key mechanisms of importance for antiviral defense. This project will provide new insights that can be translated into early genetic diagnosis, prophylaxis and gene therapy, and may pave the way for development of new antiviral therapies.

Keywords: recurrent lymphocytic mollaret s meningitis,herpes simplex virus 2,inborn errors of immunity
Constellation optimization for continuous variable QKD (COCoVaQ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark,Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 2
Project status: SIGNED

In today's highly interconnected world, secure communication between distant parties is paramount. Quantum Key Distribution (QKD) protocols, rooted in quantum mechanics, offer a promising solution to this challenge by ensuring the generation of secure keys with high data exchange rates. This project objectives seek to advance the state of secure data exchange by optimizing quantum state transmission within QKD protocols. Focusing on Continuous Variable QKD (CV-QKD), we aim to pioneer novel algorithms that not only bolster security but also enhance cryptographic system efficiency. By shaping constellations and fortifying security proofs, COCoVaQ provides imperative contributions for secure communication, safeguarding sensitive digital information. Currently, state-of-the-art CV-QKD protocols lack the sophisticated tools developed within the scope of optical communication systems, such as adaptive methods for optimal constellation optimization, which enable the transmission of secret keys at a high rate. Additionally, existing security analyses of CV QKD protocols with practical, discrete modulation often overlook critical symmetry aspects of the transmission algorithms that are imperative to establish security against arbitrary attacks. In response, our project endeavors to devise groundbreaking algorithms for constellation shaping and introduce symmetry properties to CV-QKD protocols employing discrete modulation with provable security. Notably, discrete modulation typically results in a substantial penalty on the resilience against attacks. With the aid of constellation optimization, this project aims at mitigating this penalty by between 10 and 20 orders of magnitude, ensuring a theoretically secure exchange of secret keys of high rate at long distances. Finally, COCoVaQ will showcase practical demonstrations of the entire system, bridging the gap between theory and real-world applications.

Keywords: quantum key distribution
Molecular and Genome Evolution of Prokaryotic Plasmids (pMolEvol)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 2112500.0
EU funding (EUR): 2112500.0
Participants: 1
Project status: SIGNED

Plasmids are autonomously replicating extra-chromosomal elements that play a major role in prokaryote ecology and evolution. The study of plasmid evolution has so far focused mostly on their biodiversity and effect on their host ecology and evolution. Nonetheless, the fundamentals of plasmid genome evolution remain to a large extent uncharted territory. Plasmids reside within a host cell that supplies their environmental, energetic and metabolic requirements. Consequently, natural selection operates on plasmids in two hierarchical levels: one component is the plasmid replication and inheritance within the host cell, and the other is the host fitness within the population. Studying the determinants of plasmid evolutionary success thus requires the expansion of classic population genetics theory to populations of plasmids within bacterial cells. The overarching aim of pMolEvol is to create a novel unified framework for plasmid molecular and genome evolution. This includes: 1) to quantify the effect of multilevel drift and selection on plasmid genetic diversity, 2) supply a framework for quantification of plasmid fitness and its effect on plasmid evolution, 3) characterize patterns and rate of plasmid genome evolution. Our conceptual framework will be based on empirical data from plasmid evolution experiments and reconstruction of past events from genomic information. The conceptually novel measures and approaches developed in pMolEvol open up avenues for the extension of classic population genetic theory to prokaryotic organisms. Across all domains of life, genetic information is stored, replicated and translated by similar mechanisms. Focusing on plasmids, we aim to uncover the general principles that govern the evolution of autonomously replicating genetic elements. Our ultimate goal is to describe plasmid evolution from emergence to extinction.

Keywords: prokaryote evolution,plasmid biology and evolution,experimental evolution,microbial genome evolution,molecular evolution,microbial genetics,extrachromosomal genetic elements,phylogenetics,lateral gene transfer,population genetics