Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
European platforM to PromOte Wellbeing and HEalth in the woRkplace (EMPOWER)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Australia,Italy,Italy,Italy,Belgium,Poland,Finland,Switzerland,Poland,Netherlands,United Kingdom
Call: Mental health in the workplace (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2024-06-30
Duration (months): 54.0
Total project cost (EUR): 4076054.14
EU funding (EUR): 3993398.75
Participants: 17
Project status: SIGNED

EMPOWER is a multidisciplinary research and innovation effort aiming to developing, implementing, evaluating and disseminating the effectiveness and cost-effectiveness of a modular eHealth intervention platform to promote health and well-being, reduce psychological distress, prevent common mental health problems and reduce their impact in the workplace. In collaboration with stakeholders, we will adapt existing effective interventions focused on different components (awareness and stigma, workplace conditions and psychosocial factors, stress, common mental health symptoms, early detection, comorbidity, lifestyle, and return to work) to created a combined online modular platform feasible in various workplace settings by culturally and contextually adapting it. The intervention will be implemented through a randomized controlled trial directed to employees and employers of small and medium sized enterprises and public agencies from three European countries (Spain, Finland and Poland). Both qualitative and quantitative methods will be used in the evaluation of the individual health outcomes, cost-effectiveness (from a social, economical, employer and employees perspective), and implementation facilitators and barriers. Implementation strategies relevant to the uptake of the EMPOWER intervention will be identified, including a realistic appraisal of barriers to uptake as well as evidence-based solutions to these barriers. Through scaling-up pre-existing effective and cost-effective interventions, EMPOWER is aimed at addressing the overarching challenges from different perspectives, including individual level (e.g., addressing stigma, mental health, well-being and lifestyles, taking into account legal, cultural and gender issues) and organizational level. The main outcomes effort will help employees, employers and policymakers in decision processes of new legal and contractual framework at EU and national level covering the new economy landscape.

Keywords: depression,anxiety,stress,insomnia,work,intervention,psychosocial risks,lifestyle,comorbidity,effectiveness,cost effectiveness,absenteeism,presenteeism,wellbeing,stigma,ehealth
New Tools for Innovation Monitoring (NETIM) (NETIM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain,Italy,Hungary
Call: peer learning of innovation agencies (H2020-INNOSUP-2014-5, 2014)
Start date: 2016-02-01
End date: 2017-01-31
Duration (months): 12.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

The “New Tools for Innovation Monitoring” (NETIM) project aims to capitalize on the experiences carried out by Innovation Agencies around the world concerning the most effective and simple methods for collecting, elaborating and rendering data related to the implementation processes of innovation policies and measures. For this purpose, a Twinning Advanced mechanism will be set up among the three partner agencies in order to allow them to jointly evaluate existing approaches to policy monitoring (both developed by the partners themselves and from other agencies and bodies worldwide), select the most convincing solutions and design/adapt a new monitoring tool. The selection process will be guided by a pragmatic approach, with the goal of individuating those solutions to policy monitoring that have been proven to be simple, effective and cost-efficient. On this base, a new monitoring tool will be assembled, by designing: • a suitable list of indicators • an interpretation grid for the selected indicators • an efficient data collection system • a multi-level data analysis and reporting tool (for policy makers, for beneficiaries, for larger audience). The final project output will be a Design Options Paper that will guide other agencies and bodies to the practical implementation of the NETIM monitoring tool in their regional context.

Keywords: monitoring indicators
Sweet Theranostics in Bitter Infections - Seek and Destroy (SWEETBULLETS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2022-09-30
Duration (months): 68.0
Total project cost (EUR): 1499551.0
EU funding (EUR): 1499551.0
Participants: 1
Project status: CLOSED

Bacterial infections are now a global threat demanding novel treatments due to the appearance of resistances against antibiotics at a high pace. The ESKAPE pathogens are those with highest importance in the EU and chronic infections due to biofilm formation are a particular task. Noninvasive pathogen-specific imaging of the infected tissue is not clinically available. Its successful implementation will enable the choice of appropriate therapy and boost efficacy. Furthermore, Gram-negative bacteria have a highly protective cellular envelope as an important resistance mechanism for drugs acting intracellularly, resulting in an alarmingly empty drug-pipeline. To overcome this gap, I will establish Lectin-directed Theranostics targeting pathogens via their extracellular carbohydrate-binding proteins at the site of infection for specific imaging and treatment. This will be implemented for the highly resistant ESKAPE pathogen Pseudomonas aeruginosa through 3 different work packages. WP1 Sweet Imaging: Design & conjugation of lectin-directed ligands to imaging probes, Optimization of ligand/linker, in vivo proof-of-concept imaging study. WP2 Sweet Targeting: Delivery of antibiotics to the infection through covalent linking of lectindirecting groups. Employing different antibiotics, assessment of bactericidal potency and targeting efficiency. Manufacturing of nano-carriers with surface exposed lectin-directed ligands, noncovalent charging with antibiotics. In vitro and in vivo targeting. WP3 Sweet SMART Targeting: Conjugates as SMART drugs: specific release of anti-biofilm lectin inhibitor and drug cargo upon contact with pathogen, development of linkers cleavable by pathogenic enzymes. SWEETBULLETS will establish fundamentally novel lectin-directed theranostics to fight these deleterious infections and provide relief to nosocomially infected and cystic fibrosis patients. It is rapidly extendable towards other ESKAPE pathogens, e.g. Klebsiella spp..

Keywords: lectin,carbohydrate,glycosciences
Investigating the functional impact of neurodegeneration-causing rare variants in the teleost model zebrafish (INNERVATE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

Circa 30 million people in Europe suffer from life-threatening rare diseases, which are poorly understood. This major societal burden forces patients into endless paths for a diagnosis often without cure. EU cooperation efforts between countries contribute to improve research and visibility of these diseases with a primary role of the ‘Ospedale pediatrico Bambino Gesù’ (OPBG, Italy). Here, via next generation sequencing technology, Dr. Tartaglia recently described new genetic variants, including some in the tubulin cofactors TBCE and TBCD which alter microtubules (MTs) dynamics (crucial for brain development and maintenance) and cause previously undescribed early onset neurodegeneration. Yet the underlying pathogenic mechanisms and impact on the brain physiology remain elusive. Given the difficulty to reproduce brain physiology in vitro and its general inaccessibility, a vertebrate model amenable to genetic and whole-brain in vivo investigation is necessary. With its rapid and transparent development and genetic and imaging tools improving continuously, the small teleost fish zebrafish is ideal. I will monitor live MTs behaviour and cellular processes (e.g. cell division, axons formation and innervation) in the precursor and mature neurons of zebrafish TBCE and TBCD mutants, focusing on motoneurons. To this aim, I will combine my expertise in fish neurobiology with the host’skills in human genetics (Dr. Tartaglia) and fish gene editing (Dr. Del Bene, France). In line with the current EU efforts, this work will advance our understanding on rare genetic variants causing neurodegeneration. Deciphering the role of MTs dynamics on brain physiology will be relevant also for common brain disorders and exome sequencing of undiagnosed patients will further contribute to a genotype-phenotype catalog. Via an intensive transfer of knowledge, the project will increase EU multi-disciplinary competence on rare disorders in general, providing new models for therapy development.

Keywords: rare brain diseases,neurodegeneration,microtubules,motoneurons,neuroimaging,zebrafish,in vivo
Peer Learning on Social Entrepreneurship and Social Enterprise Support (SocEn)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Italy,Spain,Hungary
Call: Peer learning of innovation agencies (H2020-INNOSUP-05-2016-2017, 2017)
Start date: 2018-07-01
End date: 2019-06-30
Duration (months): 12.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

The objective of the project is to improve and enhance the innovation support actions, activities and services addressed to Entrepreneurs and SMEs, by the different entities which aim is creation and support of innovative companies. During 12 months and through the use of Twinning Advance Methodology, the partners seek identify and share best practices based on its experience in entrepreneurship and business development within the social impact framework. The result will be documented in a Design Option Paper (DOP), which will identify and document implementation options, guidelines and implementation alternatives that we have experienced and would recommend to other innovation support service agencies.

Keywords: social enterprise,social entrepreneurship
BIOTREM - processing wheat bran into packaging products (BIOTREM)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Poland
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-08-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Project’s aim is to successfully commercialize BIOTREM technology – globally-unique, innovative and patented, sustainable method of processing by-products of the milling industry. Using modified servo-presses, the technology, allows moulding wheat-bran into designated forms. After processing the mouldings gain market value as biodegradable packaging. Their main application concerns disposable tableware or food-service take-away-containers. Biotrem packaging products are simultaneously bio-based, biodegradable within 30 days, use annually renewable agricultural side-products and are free of chemical additives. The above characteristics position Biotrem product line as a premium offer with environmental standards beyond its market counterparts. Degradable packaging, as market research show, is the fastest growing niche of the packaging industry – a business opportunity the project plans to exploit, as it provides products that meet a demand generated by both legislation (imposing decrease of packaging waste) and consumer trends (environmentally conscious attitude). Having concluded necessary R&D works and completing investments assembling the production line, the company currently strives to optimize the technology in operational conditions and to specify its short-medium and medium-long term business strategy.

Keywords: wheat bran,bio based,renewable,biodegradable,compostable,packaging,tableware,zero waste,sustainability,milling industry,innovation,by product
Structure-Based PROTAC Design In-Silico (SBPD In-Silico)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Proteolysis Targeting Chimeras (PROTACs) are small molecules that induce the degradation of target proteins of interest and have shown considerable promise as novel therapeutic agents. PROTACs are heterobifunctional compounds containing one moiety that binds to the target protein of interest and one that binds to an E3 ubiquitin ligase. Recruitment of the E3 ligase leads to ubiquitination and subsequent degradation of the target by the proteasome. The design of PROTACs largely remains an empirical process because of an insufficient understanding of the molecular basis for productive recruitment of target and E3 ligase into a ternary complex. Furthermore, there are only a handful of small-molecule ligands for E3 ligases that are amenable for PROTAC conjugation, so expanding the chemical space to PROTAC design is an important direction for the field. Virtual screening and structure-based drug design are powerful approaches for designing of drug-like molecules but their application to PROTAC design is still in its infancy. The structural complexity of the ternary complex central to PROTAC activity, and the chemical complexity of PROTAC molecules, are amongst some of the main challenges to structure-based PROTAC design. The goal of this proposal is to develop novel methodologies to contribute to systematically address these important challenges. The long-term goal of this proposal is to develop structure-based PROTAC design as an efficient, universally applicable platform for prediction, designing, and screening of effective PROTAC degraders of target proteins. The success in this project will pave the way to efficiently degrading “undruggable” targets as a powerful new modality of chemical intervention into biology and disease.

Keywords: proteolysis targeting chimeras protac,e3 ubiquitin ligase,virtual screening,structure based protac design,target protein of interest
Smart Wearable for Fatigue Tracking (SWeaT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-15
End date: 2022-07-14
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

Internet-of-Wearables (IoW) is already a reality embodied in commercial products for fitness, such as Fitbit, Apple Watch. These devices record activity data (speed, distance, heart-rate, impact forces) and are connected to the Cloud through Bluetooth enabled access points. Smart wearables of the next generation of will integrate bio-chemical sensing to capture body dynamics at molecular level and in real time. Sweat, naturally produced by the human body, will enable non-invasive access to rich sets of bio-markers. However, sweat-based IoW devices face many challenges: bio-compatibility, flexibility, durability, data integrity, low-power consumption, lightness in weight and low-cost construction. SWeaT (Smart Wearable for Fatigue Tracking) will address all these issues and will enable coaches, physicians and trainers to better analyze the performances/fatigue trade-off by real-time monitoring of athletes’ parameters. To this purpose, SWeaT will develop a low-cost wearable device capable of sensing and recording a full set of relevant electrolytes concentration in sweat, sweat rate and temperature. The device will take advantage of: (i) a custom IC in low-cost CMOS technology to provide early readout and signal digitalization (ii) micro-fluidic paths to properly manage the sweat flow during real-time measurement. A Bluetooth Low Energy module will be embedded in a sport gear to enable lightweight, minimal invasiveness, 10-to-100-meter wireless range communication. SWeaT plans to reach TRL 5 and to develop a Minimum Valuable Product by the end of the action to fully exploit the developed technology. SWeaT will be implemented at the University of Pisa with a secondment in Barcelona at the Microelectronic Institute. Through SWeaT and its tailored training plan, Dr. Dei will greatly enrich his scientific and soft skills towards his next career challenge.

Keywords: internet of wearables,smart wearables,biochemical telemetry,dehydration tracking
INNOVATIVE SCO2-BASED HEAT REMOVAL TECHNOLOGY FOR AN INCREASED LEVEL OF SAFETY OF NUCLEAR POWER PLANTS (sCO2-4-NPP)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Innovation in nuclear safety
Action type: Innovation actions
Countries involved: Germany,Germany,Italy,Slovenia,France,France,Czechia
Call: Encouraging innovation in nuclear safety for the benefit of European citizen (NFRP-2018, 2018)
Start date: 2019-09-01
End date: 2022-08-31
Duration (months): 36.0
Total project cost (EUR): 2786971.25
EU funding (EUR): 2352452.01
Participants: 11
Project status: CLOSED

The main aim of the sCO2-4-NPP is to bring an innovative technology based on supercritical CO2 (sCO2) for heat removal in nuclear power plants (NPPs) closer to the market. sCO2-4-NPP builds on results of the previous H2020 sCO2-HeRo project, where the technology was first developed and brought to TRL3. The sCO2-4-NPP technology will be a backup cooling system, attached to the principal steam-based cooling system, which will considerably delay or eliminate the need for human intervention (>72 hours) in case of accidents such as StationBlackOuts, thus replying to the need for increased safety in NPPs. Thanks to the compact size and modularity of the system, it can be retrofitted into existing NPPs but also included in future NPPs under development. Through a close collaboration between major industrial actors and highly-skilled academic institutions, the sCO2-4-NPP partners will bring the full system to TRL5 and parts of it to TRL7 by carrying out experiments, simulations, design, upscaling and validation of the technology in a real NPP PWR simulator. Regulatory requirements will be considered in the conceptual design of components and the system architecture to increase the chances of acceptance by European nuclear safety authorities and speed up the road to the market. Detailed technical, regulatory, financial and marketing roadmaps will be developed for bringing the technology to industrial use (TRL 9) after the project. The sCO2-4-NPP technology will increase NPP safety, decrease the plant overall environmental footprint and potentially lower costs for energy consumption, thus increasing the competitiveness of European NPP operators.

Keywords: npp safety,supercritical carbon dioxide,sco2 heat removal system,decay heat removal,roadmaps to market,validation virtual npp,konvoi pwr simulator,athlet,cathare,nuclear licensing
The knowledge engine for finance (Plural AI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-10-01
End date: 2019-12-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Economic growth and competitiveness are dependent on the investment in companies in order for them to innovate and advance. But the majority of merger and acquisitions deals end up failing and depleting the value of the companies involved. This in part because proper analysis and data driven decision are not being made during these deals. The current solution to this problem is human analysis, which takes a lot of time and effort and is very cost intensive. Using natural language processing, machine learning, and knowledge graph technology, Plural AI has developed a beta version of a data science platform for financial analysis capable of generating data driven reports on financial markets and potential acquisition targets. Plural AI is a gamechanger as it provides answers to complex questions and allows humans to focus on decisionmaking and strategy. Corporate finance is still behind technologically, meaning that a lot of their financial analysis continues to be unsophisticated and inaccurate. Plural AI is on the forefront of AI powered financial analysis technology. Plural AI can help to bring corporate finance to the future, helping companies to make better financial decisions. This will position us to gain a share within the €5 billion global AI fintech market. To reach our goal of changing the market and reaching a market share of 5-20% with €89 million revenues by 2024, we plan to follow a SaaS model based on an annual licence fee. Our customers are investors focused on private companies (private equity / venture capital (PE/VC)), strategic investors (internal M&A/corporate development arms of large firms), investment banks and other corporate finance advisors/consultancies. Plural AI’s technology has the potential to reduce instances of fraud in the investment process. It can also help to maximize Europe’s investments and build strong long-lasting relationships between companies.

Keywords: ai powered knowledge engine,investment decisions,natural language processing,machine,learning