Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Synthetic Biology Approach to Developing Optical NanoAnalytics (NanoBiOptics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1499495.0
EU funding (EUR): 1499495.0
Participants: 1
Project status: SIGNED

Bioengineering is the synthetic biologist’s approach to engineering materials. It allows researchers to overcome billions of years of evolution to create unnatural biomolecules equipped with interactions unfounded in nature. Biomolecules offer unparalleled molecular recognition that can be tuned by engineers to create highly specific sensors. Unfortunately, biology has its limits; many biological optical sensors rely on fluorophores with limited lifetimes and visible emissions that overlap with tissue absorption. Unlike these fluorophores, single-walled carbon nanotubes benefit from fluorescence that is indefinitely photostable, demonstrating sensitivities that can detect analytes down to the single molecule. Their near-infrared wavelengths are also transparent to tissue absorption, allowing for continuous in vivo sensing. Unfortunately, these nanomaterials lack the molecular recognition biology has to offer. In a sense, the advantages and disadvantages posed by the fields of bio- and nano-materials engineering are highly complementary. This proposal envisions a new generation of NanoBiOptic devices – devices that exploit the synergy of nano-bio hybrids – for sensing applications. We aim to bring to the nanosensor community what directed evolution has brought to chemistry; a guided approach to tuning interactions. We apply bioengineering techniques, such as artificial nucleic acid design as well as directed evolution, to circumvent current limitations in engineering nanosensors. In demonstrating these techniques, we realize previously intractable optical platforms for bioanalyte detection, as well as a single-molecule basis for imaging DNA-protein interactions, such as those found in CRISPR. Synthetic biology thus has the potential to complement the physical sciences in the engineering of new synthetic optical platforms, enabling a “revolution through evolution” of synthetic nanomaterials.

Keywords: directed evolution,bioengineering,near infrared spectroscopy,nanotechnology
Atmospheric Gas-to-Particle conversion (ATM-GTP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Finland
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-06-01
End date: 2022-05-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Atmospheric Gas-to-Particle conversion (ATM-GTP) is a 5-year project focusing on one of the most critical atmospheric processes relevant to global climate and air quality: the first steps of atmospheric aerosol particle formation and growth. The project will concentrate on the currently lacking environmentally-specific knowledge about the interacting, non-linear, physical and chemical atmospheric processes associated with nano-scale gas-to-particle conversion (GTP). The main scientific objective of ATM-GTP is to create a deep understanding on atmospheric GTP taking place at the sub-5 nm size range, particularly in heavily-polluted Chinese mega cities like Beijing and in pristine environments like Siberia and Nordic high-latitude regions. We also aim to find out how nano-GTM is associated with air quality-climate interactions and feedbacks. We are interested in quantifying the effect of nano-GTP on the COBACC (Continental Biosphere-Aerosol-Cloud-Climate) feedback loop that is important in Arctic and boreal regions. Our approach enables to point out the effective reduction mechanisms of the secondary air pollution by a factor of 5-10 and to make reliable estimates of the global and regional aerosol loads, including anthropogenic and biogenic contributions to these loads. We can estimate the future role of Northern Hemispheric biosphere in reducing the global radiative forcing via the quantified feedbacks. The project is carried out by the world-leading scientist in atmospheric aerosol science, being also one of the founders of terrestrial ecosystem meteorology, together with his research team. The project uses novel infrastructures including SMEAR (Stations Measuring Ecosystem Atmospheric Relations) stations, related modelling platforms and regional data from Russia and China. The work will be carried out in synergy with several national, Nordic and EU research-innovation projects: Finnish Center of Excellence-ATM, Nordic CoE-CRAICC and EU-FP7-BACCHUS.

Keywords: atmospheric aerosols,global challenges,air quality climate interactions and feedbacks,arctic and boreal environments,mega cities,earth surface,atmosphere interactions
Prevention of Cosmetic-Induced Non-Communicable Diseases and Micro Plastics entering Food Chains with the CosmEthics- Health App (CM)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Finland
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

CosmEthics, with its E-solutions, helps EU citizens to identify cosmetics products with potential hazard ingredients (EU Annex II prohibited chemicals, carcinogens, hormones, allergens), and helps them to find better alternatives based on scientific research and user tailored preferences (allergies, vegan, plastics). Nearly all EU citizens use some form of personal hygiene products daily. Cosmetics are a major source of water and food chain pollution via the microplastics they often contain. This video explains the problem in the industry: http://www.youtube.com/watch?v=pfq000AF1i8#t=16 This video explains our current solution (currently viewed by over 1M EU citizens): https://www.youtube.com/watch?v=G9Lv83AcUOY&feature=youtu.be&ab_channel=CosmEthics The feasibility study assesses the following objectives 1) feasibility of concept of open data web plugin (for e-commerce or authority web pages), which shows the alert icon of the product analysis (e.g red light). 2) Feasibility of concept of measurement of harmful or prohibited cosmetic ingredients with laboratory tests, 3) Assessment of collaboration with authorities on data regarding breaches so that consumers receive the information (when prohibited chemicals are found), 4) intellectual property assessment during 6 months (Jan 2017-June 2017), 5) User involvement. We are targeting the program, “Accelerating market introduction of ICT solutions for Health, Well-Being, and Ageing Well”, because we enable prevention of non-communicable diseases such as cancer and allergies, prevention of epidemics induced by cosmetics (e.g triclosan causes antibiotic resistant bacteria, or bone marrow in cosmetics risks SARS). As EU is the biggest valued cosmetic market, import of non-EU standard products provides high risk of harmful products entering the market. Seas and water ecosystems, once polluted by cosmetic induced micro plastics, is irreversible. The team has won several international prizes and is noted by Forbes.

Keywords: prevention of non communicable disease,mobile app and e service,open data plugin,cosmetic chemicals,micro plastics,preventing micro plastics in water ecosystems
Membrane-ezrin-actin interactions mediated by ezrin binding proteins in reconstituted systems (membrane-ezrin-actin)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Microvilli are tube-like membrane protrusions containing bundles of actin filaments located at the apical surface of epithelial cells. A key component of these microvilli is ezrin, a member of the Ezrin/Radixin/Moesin protein family, which provides a regulated linkage between the plasma membrane and the actin cytoskeleton. The critical role of ezrin in microvillar morphogenesis has been demonstrated. However, how ezrin is recruited to the apical surface of the cells and how ezrin contributes to the stability of microvillar morphogenesis remain elusive. Recently, a few ezrin binding partners, such as EBP50 and Eps8, have been identified and shown to function synergistically with ezrin in membrane and actin remodelling in cells. The precise mechanisms and implications of their interactions in microvillar morphogenesis are not well understood. Lately, I-BAR domain protein IRSp53 was found to colocalize with ezrin in microvilli and interact with both EBP50 and Eps8, as ezrin does. Given that I-BAR domain proteins participate in the formation of many cellular protrusions, such as filopodia, ezrin and I-BAR domain proteins may work synergistically in membrane remodelling. The goal of this proposal is to better understand the interaction of ezrin, the membrane and actin, and the role of ezrin binding proteins and I-BAR domain proteins in this interaction by using reconstituted model systems based on purified proteins combined with supported lipid bilayers or giant unilamellar vesicles. In parallel, potential common binding partners of ezrin and I-BAR domain proteins will be identified, and their role in mediating the interaction of ezrin and I-BAR domain proteins on membranes will be studied. This project will thus lead to an improved understanding of the membrane and actin remodelling activity of ezrin, and advance our knowledge of cell and eventually tissue morphogenesis.

Keywords: membrane proteins,protein membrane interaction,membrane mechanics,cell plasma membrane shape,interface physics cell biology
Novel Cyclocarbon-Porphyrin Systems: Synthesis and Properties (CarboPorph)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-06
End date: 2022-01-05
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The proposed project combines recent advancements in supramolecular porphyrin systems and polyyne chemistry to create and study novel hybrid compounds: carbo-porphyrin nanorings. This will include extensive synthetic work to find the most efficient working schemes for macrocyclic compounds with varying sizes and different peripheral substituents, while minimizing linear polymerization. Specific choice of the building blocks will be guided by computer-aided design to ensure appropriate connectivity and steric demands for subsequent cyclooligomerizations. The size selectivity will be further refined by using template-assisted covalent self-assembly utilizing differently coordinating templates. The electronic and magnetic nature of the target compounds will be studied in solution using a range of techniques, including Nuclear Magnetic Resonance spectroscopy, UV-vis-NIR absorption and fluorescence spectroscopy and electrochemical methods, additionally characterized with X-ray crystallography in the solid state. These efforts will be focused on exploring global aromatic and antiaromatic currents in the neutral and oxidized forms of the macrocycles, gaining insight into the nature of aromaticity in nanometer-size pi-conjugated systems and contributing to the design of future functional materials.

Keywords: aromatic porphyrin nanorings,carbo compounds,carbo mers,template directed cyclooligomerization
Evolution of Prophages that carry Antibiotic Resistance Genes (ARGs) and their host-bacteria in response to antibiotics and increased lytic activity (ProphARG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

In the European Union, 25,000 deaths per year are caused by multidrug resistant bacteria. This trend is predicted to increase with ever increasing misuse and overuse of antibiotics, which accelerates the evolution of antibiotic resistance (AR). An important mechanism of transferring antibiotic resistance genes (ARGs) among bacteria are temperate bacteriophages (prophages), viruses that can incorporate their own genetic material into the bacterial chromosome, thereby providing their bacterial host (which is now called a ‘lysogen’) with additional genes, such as ARGs. Despite their vast abundance in nature, our understanding of the evolution of ARG-carrying prophages is still incomplete. Therefore I will study the evolution of ARG-carrying prophages and their host bacteria. Specifically, using constructed lysogens (carrying prophage lambda+ARG) of E. coli bacteria, I will (1) use competitive fitness assays to determine the costs/benefits for bacteria of carrying prophages that encode AR and how these costs depend on environmental antibiotic concentrations and the frequency with which the prophage enters the lytic cycle (i.e. the prophage becomes active, replicates and lyses the host cell). (2) I will follow the evolution of these lysogens that carry AR-encoding prophages using a serial transfer experiment in the presence/absence of antibiotics and compounds that induce phage lysis. (3) I will sequence the evolved lysogens including their prophage genomes to detect underlying genomic changes associated with bacterial adaptation to prophage carriage. I predict that the net effect of a prophage that encodes an ARG on the growth and evolution of its host bacterium will strongly depend on both the frequency with which the phage enters the lytic cycle and the costs/benefits of the ARG. By using a novel approach that has been neglected so far (evolution of ARG-carrying prophages) this project will improve our understanding of AR evolution.

Keywords: experimental evolution,temperate phages,antibiotic resistance
Magnetic Hybrid Metal-Organic Interfaces (MagicFACE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

MagicFACE deals on the design and investigation of magnetic hybrid metal-organic interfaces by evaporation of organic molecules (phthalocyanines, porphyrins and single molecular magnets) on non-conventional ferromagnetic surface- confined alloys, which contain rare earths atoms and noble metals (Ag and Au). The project aims to give a full description of the electronic and magnetic interaction phenomena that takes places at the hybrid metalorganic interface, exploring the possibility to create highly spin-polarized surfaces to enhance the performance of quantum information processing and organic spintronic devices. Several spectroscopies and microscopies are combined to obtain a comprehensive understanding on how the hybrid metal-organic interface forms and which kind of electronic and magnetic properties it displays. The preparation of the interface will be carried out under ultra-high vacuum conditions and the structure and morphology will be analyzed using Scanning Tunneling Microscopy and Low Energy Electron Diffraction. The electronic characterization includes local Scanning Tunneling Spectroscopy, spatially averaged Photoelectron Spectroscopy and X-ray absorption Spectroscopy. The main goal is to understand the chemistry and the physical processes taking place at the interface: charge transfer, energy level alignment and hybridization effects. Moreover, the study of the magnetic behaviour of the interface will be carried out by means of Spin Polarized Angle Resolved Photoemission and X-ray Magnetic Circular Dichroism, trying to find the effect of the magnetic coupling between the ferromagnetic substrate and organic molecular layer on the spin-dependent electronic properties at the interface.

Keywords: hybrid interface,molecular physics,surface magnetism,electronic properties
The first integral control and command system for managing missions which delivers 3D cartography and georeferenced data in real-time (DRONECOP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Geointelligence Systems is a Spanish company founded in 2015 that offers services based on Geointelligence from remote sensing and unmanned aerial vehicles. Over the last 3 years, we have developed DRONECOP, the first integral general operation system for managing missions for combating natural disasters able to process data captured by a drone (video, photogrammetry) in real-time and automatically generate 3D cartography and georeferenced targets. Several regional and global emergency mechanisms exist to support disaster management, but they lack efficiency due to the unstructured existing management systems: unable to process information in real-time and to provide accurate tools for critical decision making based on objective information. With DRONECOP, natural disasters management bodies will have access to critical catastrophic areas and get accurate and updated 3D mapping information and georefereced targets in real time. This will allow them to plan their missions and make fast decision in critical moments in a much more effective way due to the objective information they will count with. Consequently, there will be a reduction in fatalities and injured among their crews and in social, environmental and economic impact of the disasters. DRONECOP will disrupt in the Mapping for Incident and emergency Market (valued at €10,440Mill in 2018) creating a new niche of integral management system for missions with real-time 3D mapping and georeferenced data that no other competitor has already achieved. DRONECOP will make any disaster management operation safer, faster and more efficient than ever. It will positively impact on the human, environmental and economic scope of any natural disaster in which it will be used.

Keywords: natural disasters,missions management,control and command,3d mapping,real time georeferencing
Adult Education as a Means for Active Participatory Citizenship (EduMAP)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Research and Innovation actions
Countries involved: Germany,Estonia,Spain,Türkiye,Greece,Hungary,Finland,United Kingdom,United Kingdom
Call: Lifelong learning for young adults: better policies for growth and inclusion in Europe (H2020-YOUNG-SOCIETY-2015, 2015)
Start date: 2016-02-01
End date: 2019-01-31
Duration (months): 36.0
Total project cost (EUR): 2498112.5
EU funding (EUR): 2498112.5
Participants: 11
Project status: CLOSED

The existing research and policy reports show that adult education policies and practices are designed and carried out in ways and using means which are not always appropriate to vulnerable minority groups. In the EduMAP Project the diversity of societal participation and the wide range of cultural contexts and communicative practices among learners will be acknowledged. In particular, the educational needs of young people with low levels of basic and functional literacy, with deficient language and cultural skills (foreign newcomers, ethnic minorities), those who have dropped out of school and those not in education or training due to handicap, are in the focus of the project. The main research question is: What policies and practices are needed in the field of adult education to include young adults at risk of social exclusion in active participatory citizenship in Europe? Through the implementation of six work packages, EduMAP will help European, national and local policymakers, educational authorities and educators to tailor adult education policies and practices to meet the needs of young adults with low levels of education or who are otherwise in a vulnerable position. The project will provide comprehensive analyses and practical insights on the efficacy of the European adult education system in preventing social exclusion and compile an inventory of successful initiatives and communicative practices in and outside the EU. Communicative ecologies in the field of adult education will be mapped and analysed, and the findings will be utilized to create innovative platforms for enhancing dialogue between the providers and potential users of educational initiatives. An IDSS will be developed for the use of policymakers and other stakeholders. The fundamental aim is to help policymakers and educational agencies to ensure that the young generations as a whole are able to acquire the skills needed to fully participate in European societies and the labour market.

Keywords: citizenship,societal participation,low levels of education,vulnerable young adults,minorities,gender issues,evidence based policies,idss