Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Bridging Academia and Enterprise by AI-powered Talent Scouting, Female Empowering, Sciencepreneurship and Prototyping for Start-up and Spin-off Ecosystems Enhancement (BridgeTTe)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Czechia,Slovakia,Sweden
Call: Expanding Academia-Enterprise Collaborations (HORIZON-EIE-2024-CONNECT-02, 2024)
Start date: 2025-06-01
End date: 2027-11-30
Duration (months): 30.0
Total project cost (EUR): 590595.1
EU funding (EUR): 499999.65
Participants: 5
Project status: SIGNED

The BridgeTTe project has been designed to overcome the most critical gaps in the European innovation landscape between academia and industry that prevent them to benefit from an efficient mutual exchange and use the potential and resources. In particular, the project will address low engagement among the innovation ecosystem actors, missing entrepreneurial competences at academia and insufficient prioritisation of research topics / their links to market / enterprise / industrial needs and are slowly able to react to trends, to name some of the problems addressed. The BridgeTTe project will do so by systemic search for local talents, strategically deploying advanced AI tools, pioneering one-of-its-kind university prototyping programs and market validation assistance, capacity-building training programme and implementing joint activities with business experts, industry clusters and excellent infrastructures from innovation hubs. BridgeTTe will maximise the value of innovation to all by fostering synergies and connectivity of two prominent Central European academic institutions, the Brno University of Technology (BUT) and Slovak University of Technology in Bratislava (STU) to the local, European and global markets by leveraging strategic cooperation with innovation catalysts connected to enterprises (JIC and ADDSEN) and outreach to leading innovation ecosystems and infrastructures (WONDER). BridgeTTe will empower sciencepreneurs, foremostly women, to transform local cutting-edge research into deep-tech start-ups and spin-offs with pan-European and global impact. Through establishing strategic cooperation networks between academia and enterprises, it will nurture the next generation of deep-tech start-ups and spin-offs. The methodology of BridgeTTe connected ecosystems will be further disseminated across the EU and serve as an example worth following, foremostly in emerging innovation ecosystems of the CEE.

Keywords: innovation ecosystem,technology transfer,deep tech start ups,capacity building training
Geometry and Rigidity in the Complex Plane and in Surfaces (GRComPaS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Greece
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 1265125.0
EU funding (EUR): 1265125.0
Participants: 1
Project status: SIGNED

The main objective of the proposal is to develop novel methods for the study of the quasiconformal geometry of metric surfaces and of subsets of the complex plane. Geometry of metric surfaces: The uniformization problem asks for conditions on a fractal metric space so that it can be transformed to a smooth space with a well-behaved transformation that preserves the geometry. In joint work with Romney the PI has resolved a major open problem and proved a general quasiconformal uniformization result for 2-dimensional spheres of finite area. The current project expects to exploit this recent breakthrough and develop an analytic theory for 2-dimensional surfaces of locally finite area under no other assumption; the classical approaches in the field require instead several geometric assumptions. In particular, the PI proposes the study of the following problems on fractal surfaces: quasiconformal classification, embedding in Euclidean space, uniformization of surfaces of infinite area, and connections between quasiconformal geometry and rectifiability. Uniformization and rigidity in the plane: A long-standing conjecture of Koebe asserts that every domain in the plane can be conformally transformed to a circle domain. This proposal introduces a wide class of domains to test the conjecture, using techniques recently developed by the PI and collaborators, in combination with the transboundary modulus of Schramm. The PI will also study the problem of uniqueness of this conformal transformation and connections to the problem of conformal removability. The latter is a rigidity problem asking whether a given set in the plane is negligible from the domain of a conformal map. The PI has recently displayed several examples of (non)removable sets and has identified a new general class of sets that are conjectured to provide a characterization of removable sets. The PI will study this conjecture and several related deep open problems.

Keywords: metric surfaces,uniformization,quasiconformal geometry,quasisymmety,rectifiability,complex analysis,conformal removability,complex dynamics,conformal rigidity,circle domains,koebe s conjecture
THERAPEUTIC EPIGENETIC ENHANCEMENT OF THE INNATE IMMUNITY TO EFFECTIVELY COMBAT ANTIMICROBIAL RESISTANCE [IN-ARMOR] (IN-ARMOR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Iceland,Sweden,Spain,Finland,France,Netherlands,Belgium,Ukraine,Czechia
Call: Pre-clinical development of the next generation of immunotherapies for diseases or disorders with unmet medical needs (HORIZON-HLTH-2022-DISEASE-06-two-stage, 2022)
Start date: 2023-05-01
End date: 2027-04-30
Duration (months): 48.0
Total project cost (EUR): 5998972.5
EU funding (EUR): 5998972.25
Participants: 18
Project status: SIGNED

Antimicrobial resistance (AMR) & multi-drug resistance, whereby pathogens evolve to resist antibiotic drugs, is designated by WHO one of the top 10 health threats of our time and is a top 3 priority health threat requiring EU level coordination. AMR was estimated to be linked to 4.95 million deaths in 2019. The next global pandemic could be a multi-drug resistant bacterium, or emergence of ‘pan-drug’ resistant strains (resistant to all existing drugs). Alternative therapeutic approaches are proving to be expensive and slow to develop, whilst also facing the risk of evolving strains. The innate immunity presents the strongest potential to tackle AMR as it can generate antimicrobial molecules and proteins that directly inhibit microbial survival. Inducing such proteins has shown effective antimicrobial activity against bacteria, viruses, fungi & protozoa. Building on this approach, leading professors and researchers from 9 Universities and research institutes are collaborating with 7 medical and industry partners representing 9 EU countries to introduce a novel class of immune system inducers able to enhance the body’s own innate microbial defence mechanisms to combat AMR and reduce incidence of the 13 listed most dangerous infections (including 2 of the top 3 priority-1 infections). IN-ARMOR will optimise an already developed drug platform using Computer Aided Drug Design, and in-silico approaches, in tandem with a nanotech-based drug delivery system for the first target indication. The developed therapy will be pre-clinically validated for safety and efficacy in-vitro and in vivo to complete all investigational Medicinal Product requirements. Upon completion, IN-ARMOR will be prepared for clinical validation. Upon commercialisation, IN-AMOR could potentially save more 4Mn lives worldwide and result in the significant burden reduction of antibiotic development with long-term cost reduction impact of €107Bn, whilst reducing the global disease burden by 96.84Mn DAL

Keywords: antimicrobial peptides antimicrobial resistance gastro intestinal epigenetics aroylated phenylenediamines chem informatics nano drug encapsulation
The New Presence – Innovations from the North (NePNorth)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EU prize
Destination: European Capital of Innovation Awards
Action type: Recognition Prize
Countries involved: Finland
Call: The European Capital of Innovation Awards (Rising) (HORIZON-EIC-2024-ICAPITAL-PRIZE-02, 2024)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: CLOSED

Oulu is an insightful and down-to-earth city that lives and breathes on the terms of the Northern nature. From its world-class research facilities to its vibrant startup ecosystem, the city of Oulu has consistently demonstrated a commitment to fostering new thinking, advancement, collaboration and entrepreneurship. The city’s unique blend of academic excellence, industry collaboration, public engagement and northern spirit creates an environment where innovation thrives. Oulu and North Ostrobothnia ranks number one in Finland in RDI spending, 5,3% of regions GDP. The national target set by the government is to reach 4% RDI spending by 2030. For more than half a century, Oulu's ICT know-how has produced development and new innovations for the whole world, and today almost 3 billion people around the world use the technology developed in Oulu every day The main themes in the city of Oulu’s Innovation capital 2024 award application are 1) Skills for a sustainable future and continuous learning 2) Long history of cooperation and continuous development of the local R&D ecosystem 3) Co-development and experiments: The city as a testing ground for innovations The city's commitment to youth engagement is exemplary. Oulu's educational institutions, from primary schools to the University of Oulu, emphasize STEAM education and digital literacy, ensuring that young people are well-equipped for the challenges of tomorrow.

Keywords: local innovation ecosystem,clusters,metaverse,continuous learning,collaboration,startups
Stratification, Management, and Guidance of Hypertrophic Cardiomyopathy Patients using Hybrid Digital Twin Solutions (SMASH-HCM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Finland,Italy,Netherlands,United Kingdom,Germany,Ireland,France,Greece
Call: Integrated, multi-scale computational models of patient patho-physiology (‘virtual twins’) for personalised disease management (HORIZON-HLTH-2023-TOOL-05, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 8546366.25
EU funding (EUR): 8546366.25
Participants: 16
Project status: SIGNED

Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease (prevalence 1:200 - 1:500), manifested by thickening of cardiac walls, increasing risks of arrhythmia, and sudden cardiac death. HCM affects all ages - it is the leading cause of death among young athletes. Comorbidities due to gene mutations include altered vascular control, and, caused by HCM, ischemia, stroke, dementia, or psychological and social difficulties. Multiple causal mutations and variations in cellular processes lead to highly diverse phenotypes and disease progression. However, HCM is still diagnosed as one single disease, leading to suboptimal care. SMASH-HCM will develop a digital-twin platform to dramatically improve HCM stratification and disease management, both for clinicians and patients. Multilevel and multiorgan dynamic biophysical and data-driven models are integrated in a three-level deep phenotyping approach designed for fast uptake into the clinical workflow. SMASH-HCM unites 8 research partners, 3 hospitals, 3 SMEs, and a global health-technology corporation in collaboration with patients to advance the state of the art in human digital-twins: including in-vitro tools, in-silico from molecular to systemic level models, structured and unstructured data analysis, explainable artificial intelligence - all integrated into a decision support solution for both healthcare professionals and patients. SMASH-HCM delivers new insights into HCM, improved patient care and guidance, validated preclinical tools, and above all, a first HCM stratification and management strategy, validated in a pilot clinical trial, and tested with end users. Thus providing a cost efficient and effective solution for this complex disease. SMASH-HCM develops a strategy towards fast regulatory approval. In reaching its goals, SMASH-HCM serves as a basis for future digital-twin platforms for other cardiac diseases integrating models and data from various scales and sources.

Keywords: hypertrophic cardiomyopathy,machine learning,artificial intelligence,in silico models,precision medicine,data driven
Fast-Driven Quantum Dot-Based Minimal Kitaev Chains (FDQKit)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 252180.0
EU funding (EUR): 252180.0
Participants: 1
Project status: SIGNED

Majorana bound states (MBSs) are exotic quantum states with nonlocal and nonabelian properties, making them a novel phenomenon in condensed matter physics and a promising basis for quantum information technology. A platform based on double quantum dots coupled to a superconductor was developed to address disorder-related challenges in realizing MBSs that plague other set-ups. Proposed by the supervisor, this approach produces poor man's Majorana bound states (PMMs) and is now one of the most promising paths toward realizing MBSs. However, under realistic conditions, PMMs are not fully identical to topological MBSs. The goal of this project is to theoretically investigate the use of Floquet engineering methods—specialized techniques for controlling quantum systems through fast periodic driving—to assess the Majorana character of PMMs in QD-based platforms. By combining the supervisor's expertise in PMMs with the fellow’s background in Floquet engineering, the action aims to achieve breakthroughs in understanding and manipulating these elusive quantum states. Specifically, the project will develop new ways to measure the similarity of PMMs to true topological MBSs. Furthermore, it will establish innovative protocols for performing nonabelian exchange operations, which are essential for proving the exotic properties of PMMs. The project’s success will be supported by collaborations with leading theoretical and experimental research groups. By the project's conclusion, the theory aims to have established a new benchmark for analyzing PMMs in QD-based platforms and lay the groundwork for first experimental demonstrations of nonabelian physics with a potentially large impact for future quantum technologies. The fellow will be taken to a leadership position in the field of topological quantum systems, with excellent future career prospects.

Keywords: nonequilibrium dynamics,floquet engineering,open quantum systems
The neural mechanism of scale-invariant creative search (CreativeBrain)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1998000.0
EU funding (EUR): 1998000.0
Participants: 1
Project status: SIGNED

The human brain efficiently searches enormous mental spaces of thought for solutions to a given question. How is this done? The growing importance of creative search has sparked a surge of interest in mapping the relations between people’s creative search strategies and the structure, activity, and connectivity of their brain. Yet to date there are no coherent computational principles to bind behavioral, computational, and neurobiological findings together into a mechanistic understanding of creative search. CreativeBrain uses two such computational principles: scale-invariant sensing and Pareto optimality. Scale-invariant sensing is essential for a robust search in environments with signals that span many orders of magnitude like in creative search. Pareto optimality asserts that individual differences stem from different balancing between competing tasks that need to be optimized and thus explains the utility of these individual differences. CreativeBrain will employ state-of-the-art computational and analysis methods from systems biology to infer the neural mechanism of creative search on the levels of function, computations and neural implementation. This will be the first comprehensive research effort that ties these findings to a mechanistic theory of creative search that also explains the utility of neural individual differences. The project will result in a breakthrough in our understanding of how the human brain can efficiently search in vast spaces of thought. On a broader scale, CreativeBrain will open a new front in the interdisciplinary studies of the mind and brain, offering a principled way to unite neurobiological, behavioral, and computational aspects into one holistic and mechanistic view. By doing so it will contribute significantly to the promise of computational modeling for connecting different levels of inquiry of a higher cognitive function in the brain and can thus be extended to other cognitive processes and systems.

Keywords: computational cognitive science,foraging in the mind,exploration exploitation search,pareto analysis,scale invariant sensing,fold change detection,creative search,network neuroscience
Disrupting Buddhist circular economies: excess and abandonment in contemporary Japan (REFUSE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: CLOSED

Anti-materialism is the most pervasive popular assumption about Buddhism that obscures Buddhism’s material presence and its environmental impacts. Problematising such moulds, this ethnographic project will demonstrate how Buddhist materiality drives Buddhist circular economies, rooted in practices of merit-making and inherited ritual labour. By tracing Buddhist objects’ biographies and illuminating the circular nature of Buddhist material exchanges, I investigate how things given to local temples generate excess and abandonment practices in contemporary post-growth Japan. Through histories of these objects and their relations, I uncover how demographic hyper-ageing, regional depopulation, and changing consumption patterns inform and disrupt Buddhist material exchanges: how family altars and other personal ritual items, as well as meritorious food, land and object donations get caught up in discard, disposal, and reuse cycles and what emotional, ethical, practical, and spiritual implications ensue. As such, I will illuminate how Buddhist practices for processing accumulation and abandonment of Buddhist gifts are key to understanding contemporary Buddhism, and the wider issues of consumption, recycling, and aspirational non-waste economies they inhabit. I will therefore consider Buddhist giving as forces that generate and handle excess/abandonment that challenge the viability of the circular economy ideal by producing waste. Global concern about waste continues to rise: this research interrogates the waste-making impacts of religious activity and assesseses the spiritual and practical implications of managing religious excess in the world’s fastest ageing society. It complements, and is complemented by, the research at the University of Copenhagen’s Center for Contemporary Buddhist Studies interrogating Buddhist economic entanglements and waste that is created by Buddhist economic exchanges, thus supporting my development as an expert within this critical field.

Keywords: buddhism and consumption,buddhism and waste,demographic transformations,circular economy,buddhist materiality,excess,japan,affect
Deconstructing the role of trans-cellular ion transport in organ formation and function (QuantiCl)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2026-03-31
Duration (months): 30.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

Solute transport across epithelial cells is of vital importance for the function and development of many organs, for instance, the pancreas, liver, and intestine. Within the pancreas, bicarbonate is secreted from the ducts in order to neutralize stomach acid in the duodenum. The secretion of bicarbonate over the epithelial membrane is coupled to chloride transport in the opposite direction. The mechanism of this transport is complex due to the redundancy of transporters, protein-protein interactions, and multiple regulation and signaling mechanisms. Thus far the field relies on either bulk measurements, for example using Ussing chambers, or studies on isolated individual proteins. A more profound and quantitative understanding of epithelial transport cannot be obtained solely by either of these strategies but requires a combination of both: addressing individual proteins within their native cellular environment. Therefore, I will establish the contribution of individual transporters in epithelial chloride transport in human pancreatic duct cells by using inhibiting nanobodies to perturb the system. Then I will determine the plasticity and response of the cells to these inhibitions by measuring protein expression using transcriptomics and quantitative mass-spectrometry. Next, I will perform quantitative chloride measurements across epithelial cells, simulating in-organ conditions by changing the composition of the apical solution. Finally, I will elucidate the role of chloride transport in pancreatic duct formation by inhibiting key chloride transporters in 3D pancreatic organoids. Taken together this project will yield quantitative insights into transcellular chloride transport, within the full complexity of the native cellular environment.

Keywords: epithelial transport,chloride,pancreas,nanobodies,organoids