Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The roles of legitimacy and significance in higher education accreditations (ROLEG-SIG-ACCREDIT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-11-05
End date: 2012-11-04
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

In this study I will assess faculty perceptions of European higher education accreditations’ legitimacy and significance and the extent to which these perceptions influence the ways in which accreditations are actually implemented. My research will also assess the role that other factors such as identification with the school and faculty background have on faculty perceptions’ formation. The main strength of this study is its longitudinal design. I will assess faculty perceptions before and after these accreditations take place. This will allow me to better causally link faculty perceptions, attitudes, and behaviours in relation to the accreditations. The context of the study will be that of accreditations linked to the new European Higher Education Area (EHEA). Within such context, this research aims at: -Assessing quantitatively the mediating role of perceptions of legitimacy and significance in shaping faculty reactions to evaluations. -Testing longitudinally the effects of perceptions on attitudes, and attitudes on implementation behaviours. -Assessing the extent to which different evaluation contexts (more versus less threatening) affect the ways in which other variables such as identification or faculty background impact faculty perceptions of evaluations. Last but not least, my project will also involve an ethnographic study of these accreditations to better understand how faculty experience them in real time. With such ethnographic data I intend to build theory on how faculty make sense of European accreditations at their schools. The qualitative findings obtained with my ethnography will be extremely valuable to complement my quantitative findings on perceptions and attitudes.

Keywords: social psychology,organization psychology,bologna accreditations,legitimacy,significance,attitudes,identification
Molecularly targeted therapy for T cell acute lymphoblastic leukemia (MOLTALL)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Immunity and infection
Countries involved: Belgium
Call:  (ERC-2007-StG, 2007)
Start date: 2008-10-01
End date: 2013-09-30
Duration (months): 60.0
Total project cost (EUR): 1384632.0
EU funding (EUR): 1384632.0
Participants: 1
Project status: CLOSED

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive T cell malignancy that is most common in children and adolescents. Our current understanding of the molecular genetics of T-ALL indicates that leukemic transformation of thymocytes is caused by the cooperation of mutations that affect proliferation, survival, cell cycle, differentiation and self renewal. Molecular analysis has identified a large number of T-ALL specific oncogenes, but the genetic defects that are implicated in the aberrant proliferation and survival of the leukemic cells remain largely unknown. It is the aim of this project to continue the molecular characterization of T-ALL using genome wide analyses, focused RNAi screens, and drug library screens to identify oncogenes that specifically provide proliferation and survival advantages, as well as other targets for therapy in T-ALL. In addition, we will study the cooperation of these oncogenes with other oncogenic events using in vitro and in vivo mouse models, and use those models for the development and characterization of novel therapeutics. This project will generate novel insights in the molecular pathogenesis of T-ALL and aims at translating this information towards novel targeted therapies.

Keywords: oncogene,therapy,proliferation,apoptosis,differentiation,micro-array,sirna,chemical genetics
Unlocking the European Union convergence region potential in genetics (ECOGENE)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: Unlocking and developing the Research Potential of research entities established in the EU�s Convergence regions and Outermost Regions
Action type: Coordination and support actions
Countries involved: Estonia
Call:  (FP7-REGPOT-2007-1, 2007)
Start date: 2008-02-01
End date: 2011-01-31
Duration (months): 36.0
Total project cost (EUR): 1217784.0
EU funding (EUR): 1085857.0
Participants: 1
Project status: CLOSED

Arising from the outlined conceptual principles, objectives of the proposal are formulated primarily in order to improve the quality of our research capacity, in particular as far as participation of EBC in FP7 is concerned, but also wider, keeping in mind specific needs as well as possibilities related to the present-day Estonian R&D policy in its socio-economic context. Based on the evaluation of current needs and our earlier experience, the work programme is almost exclusively addressing human capital development, leaving only minimal part of the resources asked for material resources. The work programme foresees different work packages serving the objectives, but largely independent in their fulfilment. Workshops and hands-on training courses, open internationally, will be carried out both to improve scills of our researchers, as well as in order to disseminate particular knowledge, gathered here. Organizing/supporting already traditional international Gene Forum conferences allows to make our R&D visible for invited participants from leading groups in Europe. “Women in science” sub-programme will be included into the general package of measures to unlock “hidden resources”, alongside with attractive repatriation scheme. Knowledge transfer between EBC and well established research groups elsewhere is supported by mobility package for different categories of researchers and is seen as measure to build strong informed personal contacts, encouraging preparation of joint research proposals, twinning of research groups.

Keywords: human resources,capacity building,know-how transfer,visibility enhancement
Gamma Ray Bursts and Their Afterglows (GRBANDAFTERGLOW)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-01-01
End date: 2011-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

More than thirty years have passed since the detection of Gamma-Ray Bursts (GRBs) was first reported and enormous observational and theoretical efforts have been devoted to understanding this enigmatic phenomenon. Today, the GRB enigma, once one of the greatest mysteries in astrophysics, is partially solved: GRBs are the death throes of massive stars and the birth cries of black holes. Yet these objects continue to fascinate astronomers and the general public due to their unparalleled brilliance, the amazing relativistic bulk Lorentz factors involved, and because the conditions that lead to a GRB are still mysterious. What makes a massive star produce a GRB rather than a supernova? In this focused proposal, we concentrate on issues related to the geometry of the ejecta as a jet. We propose to construct, for the first time, relativistic two-dimensional self-similar hydrodynamic solutions. We will utilize these solutions to better understand relativistic jets, their lateral spreading and their interaction with the surrounding medium. Our research will illuminate the energetic content of the events, explore their geometrical diversity, and more accurately determine how frequent they are in the universe. We will explore an innovative way to identify orphan afterglows using the upcoming satellite GLAST.

Keywords: gamma ray,afterglow,relativistic hydrodynamics
Bridging Life Science Research and SMEs in the Baltic Sea Region – Putting Cluster Policies into Practise for the Benefit of SME´s (BRIDGE-BSR)

Framework: FP7 — Capacities
Programme: Regions of Knowledge
Destination: Transnational cooperation between regional research-driven clusters
Action type: Coordination and support actions
Countries involved: Germany,Poland,Denmark,Germany,Finland,Latvia,Estonia
Call:  (FP7-REGIONS-2007-1, 2007)
Start date: 2008-01-01
End date: 2010-09-30
Duration (months): 33.0
Total project cost (EUR): 871995.0
EU funding (EUR): 679983.6
Participants: 8
Project status: CLOSED

Cluster development is an integrated tool in the Baltic Sea Region (BSR) to increase impact of policies and enhance cooperation between the public/private sectors. However there is a broad gap in cross-border efforts to support SME based innovation beyond the interests from the single regions. BRIDGE-BSR develops tools to overcome the gap within life sciences/biotechnology in BSR, named ScanBalt BioRegion. BRIDGE-BSR will identify regional bottlenecks in ScanBalt BioRegion for bringing the benefits of academic research to SME´s, develop a regional innovation agenda, promote mentoring, use of best practises and bench marks plus initiate pilot activities. Partners represent triple helix clusters (public authorities, companies, universities), a tech transfer specialist, a NCP and a cross-border cluster collaboration. BRIDGE-BSR builds on: Analysis: (1) An analysis of regional cluster innovation strategies for bridging Academia and SME´s; (2) An analysis of Intellectual property bottlenecks (IP) and development of IP indicators; (3) An analysis of regional SME financing bottlenecks and mapping of investors. Desk studies, workshops, expert panels, visits are the tools. Pilot activities: BRIDGE-BSR initiates 3 pilot pilot activities: (1) Model development for trans-regional integration of IP-management; (2) A BSR life Science investment structure; (3) Shared SME support service. Innovation agenda, Mentoring, Implementation: An Innovation agenda for ScanBalt BioRegion is delivered based on the analysis, the pilot activities and preparatory work. A BRIDGE-BSR Innovation Council provides expert knowledge. The Innovation agenda serves for mentoring and implementation in clusters, networks and regional/national authorities. The ScanBalt Network ensures efficiency at the operative and policy level. Sustainability is ensured by existing structures to be further strengthened by Bridge-BSR. Bridge-BSR puts cluster policies into practise for the benefit of SME's.

Keywords: clusters,analysis,innovation agenda,mentoring,integration,pilot activities,structural funds
Reinforcement of Regional Microsystems and Nanosystems Centre (REGMINA)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: Unlocking and developing the Research Potential of research entities established in the EU�s Convergence regions and Outermost Regions
Action type: Coordination and support actions
Countries involved: Serbia
Call:  (FP7-REGPOT-2007-1, 2007)
Start date: 2008-05-01
End date: 2012-02-29
Duration (months): 46.0
Total project cost (EUR): 897192.0
EU funding (EUR): 799996.2
Participants: 1
Project status: CLOSED

The Centre of Microelectronic Technologies and Single Crystals, a department within the Belgrade-based Institute of Chemistry, technology and Metallurgy, is the only Serbian institution fully dedicated to research in the fields of microsystems and nanosystems. It is oriented to applied research of different solid-state sensors and detectors, microelectromechanical (MEMS) and microoptoelectromechanical (MOEMS) structures and nanostructures for a wide range of practical applications, including industry, environmental protection, health protection, etc. The Centre covers all stages of a research cycle, starting from the fundamental theory, proceeding with simulation, micro- or nanofabrication and characterization and ending with a finished device. Our vision is to boost the Centre into a regional centre of excellence in sensor micro- and nanosystems, enabling it to fully integrate into the EU research, at the same time ensuring a sustainable growth of its research resources and wider coverage of topics. To this purpose a reinforcement of labs is necessary, continual improvement of knowledge base and skills through training and increased mobility of research personnel, networking and joint research with EU teams, but also enhancement of the Centre's visibility through knowledge dissemination to both experts and the general public. The Centre already possesses a number of advanced technologies and a large expertise and know-how in numerous fields of semiconductor science, planar technology including photolithography, chemical engineering, thin film technologies, micromachining and other procedures specific for microsystem and nanosystem technologies. In this moment the teams of the Centre are engaged in a number of modern topics, including microcantilever-based nanosensors, cavity-enhanced optical detectors and novel sensors utilizing photonic bandgap materials and electromagnetic metamaterials.

Keywords: regional potential reinforcement,nanoscience
Re-conceptualizing party democracy (PARTYDEMOCRACY)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Institutions, values, beliefs and behaviour
Countries involved: Netherlands,United Kingdom
Call:  (ERC-2007-StG, 2007)
Start date: 2008-10-01
End date: 2013-09-30
Duration (months): 60.0
Total project cost (EUR): 1619522.0
EU funding (EUR): 1619522.0
Participants: 2
Project status: CLOSED

The aim of this project is to provide an empirical and theoretical re-conceptualization of political parties and party democracy. The challenge of democratic legitimacy faced by political parties in modern democracies derives principally from their deteriorating relationship with society, which has been accentuated by a growing disengagement of citizens from conventional party politics. However, whereas parties are conventionally being understood in terms of their linkages with society, this project proposes to rethink parties in terms of their linkages with the state and party democracy as based on a conception of parties as public utilities rather than private associations. More specifically, it intends to investigate the contours of such a new conception of political parties and party democracy through a particular focus on the management of parties by the state through public law and regulation. The project will thereby bridge the existing gap between the empirical study of parties and normative democratic theory and integrate the disciplines of political science and constitutional and public law through a systematic and comprehensive longitudinal and comparative analysis of party regulation in post-war European democracies. In doing so, it will push the boundaries of conventional empirical research on political parties as well as the normative paradigms of modern democracy and will contribute to a better, and more meaningful, understanding of the future of representative democracy and the role of political parties within it. In doing so, moreover, it will go significantly going beyond conventional – and ultimately unproductive – approaches which, by proposing the revitalization of historically dated organizational linkages between parties and society as the way forward, implausibly suggest that the irreversible process of party transformation can be put to a halt or turned round.

Keywords: political parties,party democracy,parties and the state,party regulation,democratic theory,constitutional and public law
Growth control by the TOR signalling network (TOR SIGNALLING)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: Switzerland
Call:  (ERC-2007-StG, 2007)
Start date: 2008-09-01
End date: 2013-08-31
Duration (months): 60.0
Total project cost (EUR): 965449.54
EU funding (EUR): 965449.54
Participants: 1
Project status: CLOSED

The Target Of Rapamycin (TOR) kinases reside in two distinct multi-protein complexes: TOR Complex 1 (TORC1), and TORC2. These two complexes are conserved among eukaryotes and function in signalling pathways that regulate different aspects of cell growth. By exploiting the facile genetics of the model eukaryote Saccharomyces cerevisiae, my lab aims to flesh out details of the TOR signalling network with the ultimate goal of understanding how cell, organ and organism growth is regulated. Specifically, the molecular mechanisms that regulate their activity, and the effectors by which TORC1 and TORC2 influence their distal readouts, remain largely unknown. Using both hypothesis-driven approaches and unbiased genetic screens we want to learn how TORC1 activity is regulated by environmental cues and to identify the physiological regulators of TORC2. In addition we will use biochemical approaches to elucidate the signalling mechanisms that couple TORC1 and TORC2 to their downstream effectors/readouts. Lastly, given the conservation of the TOR complexes and their clinical importance, especially in oncology, we will employ both directed chemistry and ‘target-inferred’ high throughput chemical library screens to identify drug-like compounds that inhibit yeast and mammalian TORC1 and TORC2.

Keywords: target of rapamycin,protein kinase,cell growth,nutrient sensing
INNOvation beneFITs Europe (INNOFIT)

Framework: FP7 — Capacities
Programme: Regions of Knowledge
Destination: Transnational cooperation between regional research-driven clusters
Action type: Coordination and support actions
Countries involved: Italy,Czechia,Netherlands,Germany,Germany
Call:  (FP7-REGIONS-2007-1, 2007)
Start date: 2008-02-01
End date: 2010-07-31
Duration (months): 30.0
Total project cost (EUR): 1024260.0
EU funding (EUR): 914981.0
Participants: 6
Project status: CLOSED

Having registered in 2006 the highest number of patents world-wide, Europe is deficient in benefiting from investments in knowledge. There is little demand for technology and customer oriented products and services. The goal of INNOFIT is to further the regions’ capability of “demand creation”, which allows SME, larger firms and research institutions to benefit from sales of products and services based on its knowledge. The proposal follows the strategy of “backing European winners” in their effort to catch up with global best regions. The consortium is composed of European SatNav regions, currently undertaking Galileo project. The proposal is produced by the best Research and Development Clusters of the European Galileo/SatNav industry: Holland Rijnland and regions of Munich, Rome and Prague and its innovation and entrepreneurship centres. Aim of INNOFIT shall be focused on excellence in capability of demand creation for the Galileo downstream market from which a new 9 Billion € industry with over 140.000 jobs is expected to emerge. To achieve this INNOFIT will identify global best practices (WP 2) and state-of-play in the European regions of knowledge with show cases of demand creation capabilities that are adapted to European regions (WP 3). Integration activities in a joint action plan take place in WP4. Sustainability of project results is driven by the need for demand creation for new services from Galileo that will be operational by the end of INNOFIT. The innovation of INNOFIT is to assume that demand is not a given but can and need be created by forward looking activities of managers and policy makers. The focus here is on entrepreneurial initiatives supported with open innovation environments and living labs so that future customers and developers interact in the creation of new innovative services for Galileo applications. The project results will be disseminated through mentoring in the network of SatNav regions (WP5) and beyond SatNav industries limits.

Keywords: open innovation living lab commercialization of technology research driven clusters technology marketing demand creation integration
Adaptation of Virus Genomes to Insect Immunity (GENOVIR)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: France
Call:  (ERC-2007-StG, 2007)
Start date: 2008-10-01
End date: 2014-06-30
Duration (months): 69.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 1
Project status: CLOSED

How ecology shapes genomes is a key question to be addressed in the postgenomic era. A leading theory states that species evolve as groups of genomes adapting to particular ecological niches. Thus, shifts to a new ecological niche should be connected to genome divergence, and ultimately to the making of new species. So far we know little on how ecological adaptation affects genomes, because of the difficulty of simultaneously studying evolution at both ecological and whole genome levels. Insect viruses are ideally suited to study this question because their ecological niches are defined by their hosts and because of the nature of their genomes. The transmission of baculoviruses as groups of genomes sets them apart for studying the effect of niches on populations. Their molecular biology is also well understood, which makes them ideal to investigating the genetic and functional details of adaptation. They are thus unique for linking genome changes to ecological changes. Polydnaviruses have extraordinary genomes, domesticated by wasps to deliver molecular weapons to fight the immunity of their Lepidoptera hosts. Sequencing polydnavirus genomes therefore opens windows to understanding mutualism and how parasitic wasps have adapted to different hosts. Lastly, the diversity of insect viruses provides an exceptional opportunity to examine if different evolutionary lineages have converged toward similar genomic solutions to respond to similar immunity and why some lineages have diversified more than others. Studying virus adaptation to the immunity of different insect species will reveal how viral genomes have been shaped by the ecological niches of their host immunity. At the frontier of ecology and genomics GENOVIR, takes on the challenge of studying ecological adaptation at the level of whole genomes. The innovative application of cutting-edge molecular and genomic techniques to the interface with ecology will transform our understanding of evolution.

Keywords: virus,insect,ecological adaptation,functional genomics,experimental evolution,phylogenetics