Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Coordination of national environment and health research programmes - Environment and health ERA-NET (ERA-ENVHEALTH)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Climate change, pollution, and risks
Action type: Coordination and support actions
Partnership: ERA-ENVHEALTH (ERA-NET)
Countries involved: France,France,France,Belgium,Ireland,Italy,Sweden,Netherlands,Netherlands,United Kingdom,United Kingdom,Israel,Germany,Slovakia
Call:  (FP7-ERANET-2007-RTD, 2007)
Start date: 2008-09-01
End date: 2012-12-31
Duration (months): 52.0
Total project cost (EUR): 2417832.79
EU funding (EUR): 1999936.25
Participants: 16
Project status: CLOSED

It is estimated that around 20% of the burden of disease in industrialized countries can be attributed to environmental factors, and the magnitude of the problem is perceived by the majority of Europeans. The assessment of health impacts is based mostly on scarce exposure data and limited information on the relationship between exposure and health. There is, therefore, a need to strengthen research in this area and to develop methods and tools which will improve the comparability of data. Member States have developed skills and expertise using different mechanisms to fund environment and health research. The scientific boundaries created by the remits of different funding organisations have frequently acted as a disincentive to collaborative working. Although aims are towards relevance and efficiency, the results remain dispersed and not of actual support for policy-making. Therefore, results of the studies in ERA-ENVHEALTH will lead to the proposal of a coherent set of proposed priorities, implementation of joint activities, and common calls. ERA-ENVHEALTH, by bringing together 16 participants from 10 countries, will contribute to establish collaboration among the different funding organisations of environmental and public health research communities.

Keywords: coordination,national research programme,environmental health,human health,exposure assessment,risk assessment,risk analysis,health impact assessment
Precipitation pattern effects on plant-soil microbial interactions (PPEPSI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2007-4-1-IOF, 2007)
Start date: 2009-03-01
End date: 2012-02-29
Duration (months): 36.0
Total project cost (EUR): 246186.81
EU funding (EUR): 246186.81
Participants: 1
Project status: CLOSED

Global environmental change is predicted in Europe to result in increased frequency and intensity of extreme climatic events, including severe droughts and intense precipitation events. Such changes will affect plant physiology, microbial activity and soil nutrient cycling, inducing changes in ecosystem functioning, with expected consequences on in plant community composition, net primary productivity and carbon balance. Thus, it is crucial to consider the effect of precipitation patterns of contrasted amplitude on the plant-soil interaction. The main objective of this project is to understand the mechanisms of the coupling between precipitation patterns and carbon and nitrogen cycling in the plant-soil microbial system. The effect of precipitation patterns of contrasting amplitude will be addressed in a multidisciplinary approach combining state-of-the-art molecular techniques with stable isotope approaches to enable a detailed understanding of the functioning of the plant-soil system that ultimately relates belowground fluxes to the activity of the soil microbial population. Changes in the structure of the active microbial community over the long term will be assessed using a high-density oligonucleotide microarray chip, a cutting-edge tool which allows to assess which prokaryotic operational taxonomic units are active in the soil. The fluxes of carbon and nitrogen between plant and soil microbes will be determined using isotopic methods. The mechanisms underlying plant-soil microbial interactions in response to contrasting precipitation patterns will be identified under controlled conditions during the outgoing phase then validated in the field during the return phase, enabling valuable insight into the future implications of changes in European summer climate for plant nitrogen availability, and providing crucial information for the development of mitigation strategies.

Keywords: climate change impact (climate change),biochemical and hydrological cycles,soil science (climate change),plant ecology,carbon cycle (climate change)
Investigation into the transduction of stress signals to the nucleus (ITSSN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2008-06-01
End date: 2010-05-31
Duration (months): 24.0
Total project cost (EUR): 180008.08
EU funding (EUR): 180008.08
Participants: 1
Project status: CLOSED

The nucleus contains distinct sub-compartments, the composition and localisation of which change during normal physiological processes, or in response to stress or disease. The molecular stimuli that provoke these changes, and their effects on gene expression are not well characterised. This proposal aims to further define the mechanisms that underlie nuclear organisation, which is fundamentally important to most eukaryotic cell-types. Moreover, as there are many diseases linked with distinct changes in nuclear architecture, a better understanding of these mechanisms will aid in the development of new treatments, and diagnosis/screening procedures. Both these outcomes will reinforce the scientific excellence of Europe. My work will focus on the dynamic behaviour of Cajal bodies (CBs), which are conserved sub-nuclear domains involved in ribonucleoprotein-complex assembly. Recently, it was discovered that upon UV-C irradiation of cells, many CB proteins redistribute into “microfoci”. One of these proteins, coilin, displayed an increase in association with a novel binding partner after UV-C irradiation, Proteasome Activator subunit gamma (PA28g). Several lines of evidence suggest that the UV-C-induced redistribution of CBs occurs via a novel pathway that promotes the formation of PA28g/coilin complexes. I will extend these observations and determine the molecular mechanisms underlying the transduction of stress signals to the nucleus, by using biochemical and proteomic approaches (including a cutting-edge mass spectrometry technique; SILAC-MS) to identify novel proteins that show increased association with coilin/PA28g following UV-C irradiation. I will also determine the role of PA28g phosphorylation in the UV-C-induced redistribution of CBs by applying gene-silencing techniques and cell biological approaches. Finally, advanced fluorescence-microscopy methodologies will be combined with MS to determine if PA28g is functionally associated with the 20S proteasome.

Keywords: nuclear structure and organisation,signal transduction,protein-protein interactions
String Field Theory: Formulation and Analytic Solutions (SFT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2007-4-1-IOF, 2007)
Start date: 2008-10-01
End date: 2011-09-30
Duration (months): 36.0
Total project cost (EUR): 335200.16
EU funding (EUR): 335200.16
Participants: 1
Project status: CLOSED

String theory is currently the most promising candidate for a unified theory of nature. It is very important to understand both perturbative and non-perturbative aspects of the theory. String field theory is a natural framework for defining string theory non-perturbatively. Following the recent analytic progress in this field, I propose to investigate analytical solutions representing lumps and multiple D-branes in open (bosonic and supersymmetric) string field theories. Another aim of this proposal is to construct type-II string field theories, using the pure-spinor formalism, followed by a preliminary study of their solutions.

Keywords: quantum field theory,string theory,non-perturbative formulation
The origin of evolutionary novelties: regulation of Hoxd genes and the evolutionary transition from fish fins to tetrapod limbs. (LIMB EVOLUTION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2009-02-16
End date: 2011-02-15
Duration (months): 24.0
Total project cost (EUR): 158032.58
EU funding (EUR): 158032.58
Participants: 1
Project status: CLOSED

The fossil record suggests that fish fins suffered sequential transformations, giving rise to limbs close to the origin of tetrapods. However, the molecular mechanisms that underlie this evolutionary transition remain unclear. Interestingly, Hoxd genes exhibit a single phase of expression during zebrafish fin development but, in contrast, are expressed in two independent phases during mice limb development. The second phase is essential for digit development, the main innovation of the tetrapod limb, and is activated by enhancer elements upstream of the HoxD cluster. This suggests that acquisition of transcriptional regulators of 5’ Hoxd genes may explain the origin of digits in the tetrapod lineage (“cis” evolution hypothesis). Alternatively, these structures may have developed due to recruitment of new binding factors that acted on pre-existent 5’ Hoxd gene enhancers giving rise to a second phase of expression during limb development (“trans” evolution hypothesis). In this project, we will discern the contribution of the “cis” and the “trans” hypothesis to explain the activation of 5’ Hoxd genes that may have lead to the origin of digits in tetrapods. To this end, we will use a methodology that allows identification of highly conserved non-coding regulatory regions using Xenopus and zebrafish transgenic assays.

Keywords: limb,development,evolution,hox gene,enhancer.
Quantum phases of a two-dimensional Bose gas (FLATLAND)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-06-01
End date: 2010-05-31
Duration (months): 24.0
Total project cost (EUR): 161942.68
EU funding (EUR): 161942.68
Participants: 1
Project status: CLOSED

The proposed project aims at the experimental study of two-dimensional (2D) quantum degenerate Bose gases. In a first stage we will explore the coherence properties of the gas below the critical temperature of the Kosterlitz-Thouless transition. One of our objectives is to reveal the superfluid character of the gas. For this purpose we will rotate the trapped cloud to excite particular collective modes, which are expected to reveal the quenched moment of inertia. Subsequently, we will investigate the coherence dynamics by interfering two initially phase-coherent 2D gases. The contrast of the interference pattern is expected to decay with a very unusual time dependence, and its observation would unveil the extraordinary character of these systems with a marginal long-range order. In a second stage of the project, we plan to implement a novel method to introduce an effective magnetic field which nucleates vortices in the atomic cloud. An artificial electromagnetic gauge field is created by subjecting the Bose gas to an optical topological potential. This method is a promising alternative to fast rotating gases and may enable us to reach the strongly correlated regime, where the physics becomes reminiscent of the fractional quantum Hall effect.

Keywords: physical sciences,quantum optics,ultracold atomic bose gases,two-dimensional systems,strongly correlated phases
Quantum graphs with quasiperiodic and random interactions (KPRDG)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-07-01
End date: 2010-06-30
Duration (months): 24.0
Total project cost (EUR): 154344.74
EU funding (EUR): 154344.74
Participants: 1
Project status: CLOSED

The project aims at studying quantum graphs (differential operators on singular one-dimensional manifolds) with various types of disorder interactions. We are going to study various sources of such interactions (random vertex couplings, random magnetic field, random metric properties, quasiperiodic interactions) and to understand their contribution to the spectral and scattering properties of the corresponding operators, i.e. Anderson localization, stability of the spectrum, fractal spectra etc.

Keywords: mathematical physics,spectral theory,quantum graphs,random operators,quasiperiodic interactions
Biotechnical functionalization of (bio)polymeric textile surfaces (BIOTIC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-04-01
End date: 2010-03-31
Duration (months): 24.0
Total project cost (EUR): 223288.66
EU funding (EUR): 223288.66
Participants: 1
Project status: CLOSED

The European textile industry, which is in transformation from labour intensive products to knowledge intensive products, has a great demand for innovative high-tech materials with special properties and added functionalities, like smart and biomedical textiles. Today’s scientific challenge is to make the enormous potential of biotechnology for production and synthesis of textile materials with advanced functionalities an opportunity for the European industry. The general aim of the research is to functionalise textile materials using modern biotechnology. The research will result in new, specific knowledge and technologies to create biotechnologically modified textile materials with unique properties. The application of functional textile (bio)polymers is typically in the field of medical, safety, care and signalling/detection but also in less obvious application areas such as e.g. tissue engineering and separation technology. Application of biotechnology is not just limited to biological materials; enzymes are able to modify synthetic materials as well. The research will be based on a concerted multi-disciplinary approach, resulting in a drastic increase of knowledge, thereby creating the possibility to produce biotechnologically functionalised materials with unique surface properties and functionalities. The research will focus on enzymatic grafting of functional groups on textile fibres, and specific enzymatic surface modification to obtain functional nano-structured surfaces. Control of enzymatic action at correct time and length scales is a prerequisite to achieve the desired functionalities. Therefore sophisticated technologies and processes will be explored in order to design novel production processes for textiles that exhibit the desired functionalities. The research will build upon expertise available at the department of Textiles at Ghent University and at biotechnological research groups at Ghent University, VIB and other European universities.

Keywords: technological sciences,biotechnology,enzymes,grafting,functionalisation,surface modification,textiles,biopolymer,polymer,nano-structuring
Between Segregation and Social Integration: Recent Immigrants and Foreign Workers in the USA and in the UK (SEGREG-INTEGRATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-4-1-IOF, 2007)
Start date: 2008-08-01
End date: 2011-07-31
Duration (months): 36.0
Total project cost (EUR): 334235.79
EU funding (EUR): 334235.79
Participants: 1
Project status: CLOSED

The central research objective of this project is to compare processes of, and opportunities for, social integration of immigrant communities in the United States and the United Kingdom. Case studies will be carried out in Seattle (WA) and Glasgow and Edinburgh (Scotland) To summarize: the project will focus on the following 1. Political contexts of migration discourses and policies 2. Contexts of integration opportunities (social integration policies) 3. Local integration/segregation contexts a. demographic characteristics of immigrants/residents b. lifestyle, welfare and well-being of immigrants/residents c. attitudes towards human rights and values of immigrants/residents 4. Potential effects of transnational immigrant community networks This project aims to examine the lives of immigrants and, in particular, attitudes towards their new surroundings and the host country in the USA (Seattle) and in the UK (Glasgow, Edinburgh). A further objective is also to ask US and UK citizens and long-term residents about their perceptions of recent immigrants. In terms of quantitative analysis the project will attempt to examine how mutual perceptions of newcomers and residents are affected by their various nationalities, religions, languages, levels of education etc. Furthermore this project investigates how government regulates the flow of immigrants and what kind of civil society organisations try to help the new arrivals and how those activities are managed. Qualitative methods will focus on specific in-depth interviews with representatives of community associations and local government organizations that have a stake in or knowledge of social integration issues. This shared UW and CRCEES project will help develop an international network relationship facilitating future research collaboration between the two participants and even other potential partners, through the applicant’s connection with Hungary and other Central European countries.

Keywords: human geography,social geography,segregation,immigration,integration,ethnic conflicts,political geography
The EU and the Building up of its Neighbors: Effects on Regional Development of Reforms in “Employment and Social” and “Industrial and Enterprise” Policies in Turkey and Ukraine (EUBN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-4-1-IOF, 2007)
Start date: 2008-10-29
End date: 2011-10-28
Duration (months): 36.0
Total project cost (EUR): 245384.37
EU funding (EUR): 245384.37
Participants: 1
Project status: CLOSED

This research explores to what extent regional policies in Turkey and Ukraine secure an economic development of regions and better off local economic and social standards, increasing economic potential and decreasing motivation to migration. The research is carried out through a comparative analysis of what the EU has classified as ‘industrial and enterprise’ and ‘employment and social’ policies, and their effects, in selected regions of Turkey and Ukraine .

Keywords: turkey,ukraine,regions,development,employment and social policies,european union,social sciences
Spatio-temporal regulation of growth factor signaling by PTPs in living cells (PTPS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2007-2-1-IEF, 2007)
Start date: 2008-03-01
End date: 2010-02-28
Duration (months): 24.0
Total project cost (EUR): 219682.47
EU funding (EUR): 219682.47
Participants: 1
Project status: CLOSED

Receptor tyrosine kinases (RTK) are involved in the regulation of cell proliferation, survival, differentiation and motility upon binding of growth factors. Disturbance of the normal balance between tyrosine kinase and Protein Tyrosine Phosphatase (PTP) activity results in aberrant tyrosine phosphorylation and has been implicated in the etiology of several human diseases, including cancer, diabetes and inflammation. Thus, it is important to understand how phosphorylation is regulated by members of both enzyme families. The objective of this proposal is to analyze the spatial regulation of Epidermal Growth Factor (EGF) signaling by PTPs in intact living cells. For this we propose to use quantitative fluorescence lifetime imaging microscopy (FLIM) in combination with functional genomic approaches. We will obtain information about which PTPs regulate the kinase activity of the EGF receptor, and the biochemical conectivity among PTP activities in response to EGF and other growth factors or hormones. Finally we will also investigate how PTP activities are regulated in response to EGF and where this happens in the cell. This spatio-temporal regulation of PTP activities will be studied by a novel approach in which enzyme-substrate complexes are directly imaged in living cells. Observation of `live´ biochemistry on a microscopic level has the advantage of preserving the network interconnectivity and spatial organization, allowing the investigation of the molecular dynamics that gives rise to the specificity in intracellular signal transduction. Since cellular responses are generated by the action of different gene products, cellular biology demands the regulation of signaling pathways at a proteomic scale to be studied to understand how signal specificity is achieved in cells and how stimuli are integrated to develop specific responses. Thus, our goal will be to obtain new information about dynamic properties of signaling networks at the proteomic scale.

Keywords: natural sciences,health sciences