Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Alzheimer's disease and Zinc: the missing link ? (aLzINK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France,France,France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-03-01
End date: 2021-08-31
Duration (months): 78.0
Total project cost (EUR): 1499947.5
EU funding (EUR): 1499947.5
Participants: 3
Project status: CLOSED

Alzheimer's disease (AD) is one of the most serious diseases mankind is now facing as its social and economical impacts are increasing fastly. AD is very complex and the amyloid-β (Aβ) peptide as well as metallic ions (mainly copper and zinc) have been linked to its aetiology. While the deleterious impact of Cu is widely acknowledged, intervention of Zn is certain but still needs to be figured out. The main objective of the present proposal, which is strongly anchored in the bio-inorganic chemistry field at interface with spectroscopy and biochemistry, is to design, synthesize and study new drug candidates (ligands L) capable of (i) targeting Cu(II) bound to Aβ within the synaptic cleft, where Zn is co-localized and ultimately to develop Zn-driven Cu(II) removal from Aβ and (ii) disrupting the aberrant Cu(II)-Aβ interactions involved in ROS production and Aβ aggregation, two deleterious events in AD. The drug candidates will thus have high Cu(II) over Zn selectively to preserve the crucial physiological role of Zn in the neurotransmission process. Zn is always underestimated (if not completely neglected) in current therapeutic approaches targeting Cu(II) despite the known interference of Zn with Cu(II) binding. To reach this objective, it is absolutely necessary to first understand the metal ions trafficking issues in presence of Aβ alone at a molecular level (i.e. without the drug candidates).This includes: (i) determination of Zn binding site to Aβ, impact on Aβ aggregation and cell toxicity, (ii) determination of the mutual influence of Zn and Cu to their coordination to Aβ, impact on Aβ aggregation, ROS production and cell toxicity. Methods used will span from organic synthesis to studies of neuronal model cells, with a major contribution of a wide panel of spectroscopic techniques including NMR, EPR, mass spectrometry, fluorescence, UV-Vis, circular-dichroism, X-ray absorption spectroscopy...

Keywords: bio inorganic chemistry,peptides,copper,zinc,aggregation,ligands
Dynamic performance modelling and controller design of a mini-scale organic Rankine cycle unit for heavy duty vehicles (DYNCON-ORC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2019-07-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Internal combustion engines of heavy duty vehicles convert only approximately 40 % of the combustion heat to mechanical power, while rest of the heat is rejected into the environment as waste heat. An organic Rankine cycle unit that recovers part of this waste heat is expected to reduce the fuel consumption and carbon dioxide emissions by about 15 % of the heavy duty vehicle. However, the waste heat from internal combustion engines of heavy duty vehicles is characterized by large fluctuations in load, making it a challenging task to control an organic Rankine cycle unit in an efficient, safe and cost-effective manner. A few prototype of mini organic Rankine cycle units for truck applications have been tested, but no commercial products are available; the aforementioned control challenge being the major barrier for their commercialization. The primary objective of DYNCON-ORC is to develop an appropriate controller for a mini-scale organic Rankine cycle unit for waste heat recovery from internal combustion engines of heavy duty vehicles. Advanced numerical models of the organic Rankine cycle unit including its components will be developed for simulation of the steady state and dynamic operational conditions. Based on the results of the dynamic model, a non-linear model predictive controller will be designed and optimized. The numerical models will be experimentally validated and implemented on a real organic Rankine cycle system. Through the collaboration with international, world-leading partners from industry and academia it is ensured that the project will be successfully completed and that the findings of the project will be transferred to and implemented in industry. In broader terms, the project will contribute to the development of a more efficient energy system for vehicles, reducing the fuel consumption and carbon dioxide emissions of the transportation sector, thus helping to attain socio-economic and environmental targets in context of the EU 2020 vision.

Keywords: waste heat recover,organic rankine cycle,heavy duty vehicle,dynamic modelling,model predictive control
Recombination-derived replication in the eukaryotic microbe Leishmania: a genome-wide process? (RECREPEMLE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

In any organism, the need to reproduce is paramount, with genome replication being the earliest step in the process. The machinery and mechanisms of DNA replication are widely conserved, with initiation occurring at defined bi-directional DNA synthesis sites termed origins. Though origins may not be conserved DNA sequences, they are defined through binding conserved replication initiator factors. In some circumstances, such as after DNA damage or origin deletion, origin-independent replication can be observed in cellular organisms and can be driven by recombination. However, origin-independent replication is not normally considered to be a genome-wide, central reaction of genome replication. Very recently, genome-wide mapping of DNA replication initiation in two species of the kinetoplastid parasite Leishmania revealed only a single locus-specific origin per chromosome. Analyses of Leishmania S phase length and DNA synthesis speed suggest that a single origin-based strategy is insufficient for complete genome duplication, indicating replication in these eukaryotic microbes relies on origin-independent initiation to support origin-directed initiation. In this proposal, I will test the hypothesis that stochastic origin-independent DNA synthesis initiation events occur throughout the Leishmania genome due to homologous recombination acting on DNA lesions. If correct, this work will reveal the first example of a cellular organism that uses origin-independent replication as a core feature of genome duplication. The genome-wide use of recombination-driven replication would alter our view of DNA replication evolution and would explain the remarkable genome plasticity of Leishmania, with implications for how the parasite adapts genome structure and gene expression in the face of changing environments. Such adaptive change is seen during acquisition of resistance to anti-leishmanial drugs, and so this work will provide insight into the use and development of therapies.

Keywords: leishmania,replication,trypanosomatids,genome plasticity,genome maintenance
SAfeguarding Biodiversity and Ecosystem seRvices by integrating CULTURAL values in freshwater management: learning from Māori (SABER CULTURAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,New Zealand
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2020-12-31
Duration (months): 36.0
Total project cost (EUR): 233276.4
EU funding (EUR): 233276.4
Participants: 2
Project status: CLOSED

Freshwater ecosystems are essential to people´s economic, cultural and social wellbeing, yet are still one of the most seriously threatened ecosystems on the planet. This conflict is reflected in political regulations that ask to halt the loss of, restore and safeguard freshwaters, their biodiversity and the ecosystem services they provide. Ecosystem-Based Management (EBM), a holistic approach advocated to help doing so, involves an overarching regulatory framework and local solutions with trade-offs and compromises - factors that make decision processes complex and easily co-opted. In SABER CULTURAL, we use a well-known participatory decision support framework (MCA) to tackle two major challenges in freshwater EBM: 1) including cultural values that build a conceptual link between natural resources/biodiversity and local knowledge, besides traditionally considered ecological and socio-economic ones, and 2) accounting for uncertainty. MCA is selected because it is i) transparent, ii) allows for the whole range of stakeholder values to be quantified and accounted for, iii) can be used to robustly test outcomes of different management scenarios, and iv) can ultimately be used to prioritise cost-effective management actions with collective buy in. To forecast ecosystem services flow under different management alternatives, MCA is coupled with a novel modelling approach (ARIES). We test the MCA-ARIES framework in New Zealand, where cultural Māori-values play a prominent role in freshwater management, and transfer the flow models to the river basin scale to inform existing management plans and policies in Europe. With SABER CULTURAL we establish new standards for freshwater management in New Zealand, create knowledge that helps reaching EU biodiversity and environment targets and add value to the dialogue among EU policy sectors. Additionally, SABER CULTURAL provides a unique opportunity to gain the skills I need to become an established, independent researcher in Europe.

Keywords: aries,collaborative decision making,cultural values,ecosystem based management,ecosystem services flow modelling,multi criteria decision analysis,restoration,uncertainty,rbmps
Enhancing economic impact in SME's in Romania by building innovation management capacity (INNO RO 4 EUROPE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Romania,Romania,Romania
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-07-01
End date: 2014-12-31
Duration (months): 6.0
Total project cost (EUR): 13960.0
EU funding (EUR): 11168.0
Participants: 4
Project status: CLOSED

The objectives of this proposal are the following:Increase efficiency and effectiveness of innovation processes of local beneficiaries of SME instrument and SMEs with significant innovation activities and high potential for internationalisation;Facilitate SME’s access to consulting services for innovation management to address bottlenecks to creation of economic impact;Support innovative SME’s to raise the company’s profitability and competitiveness on international markets.Partners deliver 2 specifically targeted service packages and base their approach on complementary experience and know-how as EEN members.The proposal also includes a general management WP consisting of coordination,communication,dissemination and quality check measures.The WPs dedicated to SMEs consist of preliminary steps (customer identification and approach, meetings), assessment of needs and gaps (specific questionnaires based on CEN/TS16555-1 Standard),assignment of innovation experts and lead coaches and supply of tailored services or facilitation of SME-coach interaction.The proposal addresses challenges such as lack of investment in research, lack of innovation management systems,insufficient supply of innovation services,unaffordable market prices.The scope of the project is to eliminate the barriers for SME innovation by supplying 7 days services.Taking account of the ongoing global crisis, innovation process from idea generation to innovation result but also leadership, management skills and other enabling factors like the ability to cooperate with third parties are considered an essential driver for development and economical recovering. The crisis is depressing investments in innovation as the first costs to be cut and particularly SMEs are concerned by this as they do not have internal resources, nor strategic vision to face the market competition.Methodologies and tools of partners complement each other and help companies manage innovation processes efficiently.

Keywords: increase the efficiency and effectiveness of innovation processes of local beneficiaries
Coincidence detection of proteins and lipids in regulation of cellular membrane dynamics (CODE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Norway
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 2
Project status: SIGNED

Specific recruitment of different proteins to distinct intracellular membranes is fundamental in the biology of eukaryotic cells, but the molecular basis for specificity is incompletely understood. This proposal investigates the hypothesis that coincidence detection of proteins and lipids constitutes a major mechanism for specific recruitment of proteins to intracellular membranes in order to control cellular membrane dynamics. CODE will establish and validate mathematical models for coincidence detection, identify and functionally characterise novel coincidence detectors, and engineer artificial coincidence detectors as novel tools in cell biology and biotechnology.

Keywords: membrane traffic,endocytosis,phosphoinositides
Creative collaboration to provide value for first time innovators - effective engagement of stakeholders and users in co-creation processes in SMEs. (Create4value)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Poland
Call: Supporting experimentation in innovation agencies (H2020-INNOSUP-2018-06-two-stage, 2018)
Start date: 2019-09-01
End date: 2022-02-28
Duration (months): 30.0
Total project cost (EUR): 60000.0
EU funding (EUR): 60000.0
Participants: 1
Project status: CLOSED

The main objective of “Create4value" project is to adapt significantly improved methodology of co-creation to the needs of “first time innovators” from the Wielkopolska region, based on testing the intrinsic and extrinsic approaches to engaging end-users and stakeholders in the process. The real challenge that PSTP and other innovation agencies face is to mobilise non-innovative companies, that have never benefited from any support in innovation implementation, despite their potential. The target group of “Create4value” project will be predefined within another project that PSTP is leading, namely “Innovators2B” (INNOSUP-05-2016-2017, „Peer learning of innovation agencies” action), which will allow PSTP to identify and reach companies from the Wielkopolska region representing the “first time innovators”. “Create4value” will build on this knowledge and deliver innovation support scheme in the form of co-creation service to the “potentially innovative SMEs”. The improved SME support scheme is based on the co-creation method applied as an organised process of product or service development, motivated by the real needs of the users and their involvement in the whole action, as well as assistance of experienced innovation agency - PSTP. The novel approach means addressing “first time innovators” with a view to unlock their innovation potential and bring economic effects in consequence. The impact of co-creation service will be measured using small-scale RCTs method. Conclusions will be prepared aiming to scale-up tested approach. This experiment will help PSTP to elaborate the method of assessing the support schemes and choose the ones with significant impact to make them a part of the PSTP offer in the future. The results of the project will be disseminated, especially to help other innovation agencies, stakeholders or regional authorities to use RCTs method when designing and testing new support schemes for SMEs.

Keywords: innovation support,co creation
Removal of Legacy Substances from polyvinylchloride (PVC) via a continuous and sustainable extrusion process (REMADYL)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Spain,Germany,Spain,Italy,Belgium,Belgium,Belgium,Belgium,France,Netherlands
Call: Methods to remove hazardous substances and contaminants from secondary raw materials (H2020-SC5-2018-2, 2018)
Start date: 2019-06-01
End date: 2023-11-30
Duration (months): 54.0
Total project cost (EUR): 4832976.25
EU funding (EUR): 4832976.25
Participants: 16
Project status: SIGNED

REMADYL aims at recycling so-called ‘old PVC’, i.e. PVC additivated with hazardous legacy substances (LS) such as low molecular weight phthalate plasticisers (mainly DEHP) and heavy metal based stabilisers (mainly lead). This ‘old PVC’ constitutes most of current hard (e.g. window frames, tubes) and soft (e.g. flooring or cables) PVC post-consumer waste. The presence of LS is a persistent barrier for PVC recycling as there are currently no economically viable solutions for their removal. To tackle this major challenge, REMADYL will develop a breakthrough single step continuous process based on extractive extrusion technology in combination with novel solvents and melt filtration, which has the potential of rejuvenating ‘old PVC’ into REACH compliant high purity PVC tuned towards the demands of various soft and hard PVC products at market competitive cost (ca €570/ton, CAPEX and OPEX included). The process also has potential for other plastics applications, e.g. removal of (halogenated) flame retardants. Using this process, REMADYL will demonstrate the circular use of PVC for window profiles and waterproofing sheets, providing a flagship example for the circular economy. The extracted phthalate plasticizers will be safely disposed (with energy valorisation) and the lead will be re-used in batteries. REMADYL will deliver a breakthrough support to the Circular Economy Package and resource efficiency targets for Europe as recovered PVC will reduce incineration and landfilling. Assuming we recycle 400kton/year of ‘old PVC’ waste within 5 years after REMADYL, this will result in a reduction of ca 800ktons CO2eq and 8ktons lead emissions. This also implies the creation of ca 800 new jobs and a turnover of ca €280million. Safety aspects will be studied, leading to best practices, standardisation input and policy recommendations. REMADYL consortium consists of 15 multidisciplinary partners, including 9 companies, and covers all expertise to maximise project impact.

Keywords: pvc polyvinylchloride,legacy substances,recycling,extractive extrusion,melt filtration,lead,dehp,phthalates,heavy metals
NGI Research Goes To Standardisation (NGI-GO2S)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Poland,Netherlands
Call: Blockchain for the Next Generation Internet (H2020-ICT-2020-1, 2020)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 7999993.75
EU funding (EUR): 7999993.75
Participants: 4
Project status: SIGNED

NGI vision is to re-imagine the Internet for the third millennium, which has to be an Internet of Human Values, resilient, trustworthy and sustainable. Blockchain and DLTs are promising technologies with enormous potential to develop a more human internet based on NGI Values, but these technologies face numerous challenges that could affect its full adoption. NGI-GO2S contributes to this vision by reinforcing the European Blockchain ecosystem and excellence in research by supporting 76 to 112 promising Bottom-up Projects [BuPs] able to develop and roll-out Advanced Blockchain Technologies [ABTs] aimed to close the scalability, interoperability and sustainability challenges. In order to get it, NGI-GO2S will leverage on Big Data Analytics technology -provided by INNEN, company specialised on advanced IT search solutions- to scout 1.000+ outstanding ‘Blockchain Talents’ and in FBC -the company specialised in building communities around innovative technologies- to attract and integrate outstanding researchers in the European Blockchain Ecosystem. An agile, transparent and flexible continuous 2-Stages Open Call scheme will select the best BuPs. We build on the experience that FBA -European leader in Financial Support to Third Parties- has on this field to make it simple and user-friendly, to allow committed ‘Blockchain Talents’ to focus on delivering solutions to important problems. Finally, NGI-GO2S will deliver a one-in-all Support Program for Standardization of ABTs that will increase the capability of BuPs by complementing their knowledge and skills with world class domain experts in fields, such as security and privacy, DLT technologies, standardisation or open commons business models. NLnet, the entity of reference in Internet domain at EU Level, will provide guidance and mentoring to tackle these topics. All this will contribute to turn excellence research into standards accepted across all kinds of application domains.

Keywords: next generation internet ngi,blockchain and dlt,researchers,hi tech startups,standardisation