Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Pulsed Dipolar Spectroscopy on Symmetric Oligomers (OLIGO PELDOR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-03-01
End date: 2017-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Pulse EPR distance measurements have evolved to a standard tool for generating long-range constraints for structural modelling via pulsed dipolar spectroscopy. Especially the pulsed electron−electron double resonance (PELDOR or DEER) method is becoming increasingly applied. The method is particularly promising for structural studies on different functional states of membrane proteins which are difficult to access by most biophysical methods. However, in samples of membrane proteins several approximations commonly made in data analysis might not be well met. The effect of the finite sample concentration is not necessarily as straightforward as in homogeneous solutions. Furthermore, systems of singly-labelled monomers forming trimers or higher oligomers not only allow extracting the oligomerisation state from the modulation depth, but also exhibit multi-spin effects hampering the distance analysis which are often neglected. These multi-spin effects should increase significantly with oligomeric state. In the proposed project we will address these problems and develop and validate alternative approaches to data acquisition and analysis in symmetric multi-spin systems.

Keywords: l106 biophysics,l107 structural biology,c101 physical chemistry,p314 physical chemistry of biological systems
Topics on probability and convexity in finance (PROCONFIN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-08-01
End date: 2017-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

A multitude of problems that fall under the scope of the field of Financial Mathematics, such as optimal investment and/or consumption, hedging of complex financial instruments, risk management and equilibrium theory, use advanced tools from the theories of Probability (including Stochastic Processes, its dynamic counterpart) and Convex Analysis. This proposal aims to develop further the methods and tools from these areas in order to address in more depth unresolved questions of theoretical and practical importance. Main focus will be given in exploring three areas: (1) Financial equilibria with heterogeneous agents in incomplete markets; (2) Viability of financial models with investment constraints and infinite number of traded assets; and (3) Hedging under model uncertainty. Versions of all three problems have been the subject of past and current scrutinised study, stemming from a desire to improve the quality of financial modelling, to allow for imperfections that appear in real markets and seek to comprehend them, as well as to address the risk involved with complicated financial positions by exploiting the structure of simple traded assets. Especially the last point is of immediate practical importance, since the field of Financial Mathematics has been criticised exactly for having failed to correctly appreciate the risks associated to introducing financial instruments of vast complexity, the incorrect valuation of which is a major factor that resulted in the recent economic crisis.

Keywords: m114 probability and statistics,e104 financial markets
Statistical Foundations for Network Modelling and Inference (STATNET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-06-01
End date: 2017-05-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This proposal is focused on the study of networks as statistical data objects. Networks are fundamental to our modern world: they appear throughout science and society, and continue to grow in size, complexity and importance. Whenever we observe entities and relationships between them, we effectively define a network of some sort. As structural objects composed of nodes and links, networks play a strong and well defined role across mathematics, science and engineering. As statistical objects made up of collections of measurements, however, network datasets require significant advances to be made in mathematical knowledge if we are to achieve fundamental understanding. The crux of the problem, and the essence of the approach to be undertaken in this research, lies in finding the right balance between complexity and parsimony. Currently, the network models that we understand fully from a mathematical viewpoint are too simple to accurately describe modern data. At the same time, models sufficiently rich to provide accurate descriptions are presently beyond our mathematical comprehension, meaning that we cannot use them to draw sound and repeatable conclusions from data. This fundamental lack of understanding slows scientific progress and affects every single economic, social or other policy decision that relies on the analysis of network data. The main objectives of this research are therefore twofold: first, to develop the new statistical theory needed to view and interpret networks properly as data objects; and second, to transform this theory into new statistical methods that will allow us to model and draw inferences from network data in the real world. These objectives reflect the fact that network modelling and inference is an area of significant international importance. It spans the many diverse fields and contexts where inferences must be drawn and substantiated based on measurements of entities and the relationships or interactions between them.

Keywords: m114 probability and statistics,statistical network models,likelihood-based statistical inference for network data.
Virtual Environments in Construction and Interior Design (VECID)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Cyprus
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-07-01
End date: 2014-06-30
Duration (months): 12.0
Total project cost (EUR): 126262.8
EU funding (EUR): 112584.33
Participants: 1
Project status: CLOSED

Hardware and software advances in developing 3D content, coupled with diminishing costs of equipment, provide an excellent opportunity for companies in the fields of construction and home design/decoration to exploit the perils of 3D technology for commercial purposes. Companies in these fields can incorporate Virtual Reality technologies in their showrooms to enable their visitors to visualize and interact with products in realistic virtual models of environments illustrative of the products’ use (e.g., view various floors or wallpapers and inspect lighting solutions in the context of virtual houses, apartments, and office spaces). With the Proof of Concept grant we aim to implement 3D visualization technologies for use by companies in interior design and construction. Our plan is to develop software and test hardware set-ups resulting in systems that link a company’s product database to a gallery of realistic VEs that can be used as templates to showcase products to consumers. We aim to offer a new service that goes beyond what is currently available to companies in these fields, which would benefit both the sales of the companies and the satisfaction of their customers. Through the proposed project we plan to test different alternatives for designing easy-to-use high-end, as well as low-cost, software-hardware systems and explore their commercialization potential through both market research and usability testing.

Keywords: 206912
Osteo-inductive coating of orthopedic and dental implants (OSCODI)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: France
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-07-01
End date: 2014-12-31
Duration (months): 18.0
Total project cost (EUR): 163965.0
EU funding (EUR): 149990.0
Participants: 1
Project status: CLOSED

In the field of orthopedics, the contact with an implant and the new bone forming is very important to ensure a proper osteo-integration of the implant. One of the challenges is to boost bone regeneration, to limit the number of surgeries and to decrease the hospitalization time in order to reduce the costs. The nature of the implantable materials used in clinical practice is very diverse as metal, ceramics and polymers are commonly used depending on the specific application and needs. The strategies already used in clinics are based on two major routes: 1) use of osteoconductive materials or osteoconductive coatings, such as ceramic coatings, which will help to improve the connexion between the new bone forming and the implant. 2) use of osteo-inductive implants that will induce bone regeneration. The only way to achieve this osteo-induction is to deliver a bioactive protein, which is a growth factor from the bone morphogenetic family (BMP). BMP-2 and BMP-7 are two members of this family already used in practice in spine, long bone and cranio-facial surgery. However, currently, their use is limited to collagen sponges or paste, to which they are associated and poorly retained. In fact, due to this poor retention, a very high amount of BMP (typically 10 mg) is required. This leads to a high cost of the product and to possible risks of adverse side effect, notably immunogenic reaction. In this context, the current challenges are : i) to deliver these BMPs from the surface of other materials, especially polymers and metallic alloy already used in clinical practice, ii) to deliver them efficiently at much lower doses. This requires the engineering of new types of osteo-inductive surface coatings. The aim of the current project is to prove that the BMP loaded films developed in the framework of the ERC StG project BIOMIM are an innovative solution to render the surface of implants osteo-inductive.

Keywords: 259370
Capitalising Notch Biomarkers in the Drug Development Market (CAPNOTCH)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Netherlands
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-09-01
End date: 2014-08-31
Duration (months): 12.0
Total project cost (EUR): 150462.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

CapNotch is the translation from discovery of multimodal cancer biomarkers of the Notch pathway to a strong market proposition. Biomarker products for validating specificity, efficacy and toxicity of preclinical compounds that target this pathway are highly wanted by academia and industry and could fuel progress in this area. One step further lays the opportunity to exploit such biomarkers for patient stratification and treatment monitoring, as well for advancing clinical trials as for supporting clinical decision making. The outcome of CapNotch should guide the selection of the most feasible proposition.

Keywords: 208259
LED Cued Learning Technology (LCLT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Netherlands
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-03-01
End date: 2014-02-28
Duration (months): 12.0
Total project cost (EUR): 168223.2
EU funding (EUR): 149999.02
Participants: 1
Project status: CLOSED

During the first period of our ERC funded study, we have developed a new technology for the field of behavioural neuroscience. This so called LED Cued Learning Technology enables us to run behaviorally cued dynamic profiles on a Ladder setup. We are confident that this technology has substantial potential and we would like to investigate to what extent it may be exploited by industry. We want to prepare a package for a potential investor, consisting of a market research, technical validation and IPR strategy.

Keywords: 294775
3D Printer for Silicon MEMS & NEMS (M&M'S+)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Sweden
Call:  (ERC-2012-PoC, 2012)
Start date: 2013-04-01
End date: 2014-03-31
Duration (months): 12.0
Total project cost (EUR): 164520.0
EU funding (EUR): 149947.0
Participants: 1
Project status: CLOSED

Additive manufacturing technologies such as 3D printing of polymers and metals have a large impact in many sectors. In this project we propose to explore ways to develop and commercially exploit a new type of 3D printing tool for manufacturing of silicon nanostructures. These 3D printers will make it possible to design and implement silicon micro- and nano-electromechanical system (MEMS&NEMS) sensors and photonic components in low volumes at affordable costs. As a result, resource-intensive semiconductor clean-room infrastructure will no longer be required to design and implement MEMS, NEMS and photonics components. A 3D printer for silicon nanostructures is made possible by employing a novel additive layer-by-layer manufacturing process that has been developed within the ERC Starting Grant project M&M´s (No.277879) lead by the PI. This process is based on alternating steps of chemical vapour deposition (CVD) of silicon and local implantation of gallium ions by focused ion beam (FIB) writing. In a final step, the defined 3D structures are formed by etching the silicon in potassium hydroxide (KOH), where the ion implantation provides the etching selectivity. The feasibility of the technology has been demonstrated within the ERC-M&M´s project by forming 3D silicon structures with layer thicknesses of 40 nm and lateral dimensions as small as 30 nm. To implement a 3D printer that can manufacture 3D silicon nanostructures from computer-generated 3D graphics, the steps of focused ion beam (FIB) writing and silicon deposition have to be combined as a fully automated switched process in a single tool.

Keywords: 277879
Telehaptic Micromanipulator System (TOUCHCELL)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: United Kingdom,United States
Call:  (ERC-2012-PoC, 2012)
Start date: 2014-01-01
End date: 2015-06-30
Duration (months): 18.0
Total project cost (EUR): 168218.69
EU funding (EUR): 149995.0
Participants: 2
Project status: CLOSED

The ability to handle individual cells and operate on them safely and efficiently is increasingly important in a number of fields such as biotechnology, pharmacology, agriculture, oncology, genetics, neuroscience and embryology. In our ERC-AdG project, we have already demonstrated a micromanipulation system that enables a user to touch, manipulate and assemble individual algae cells and polystyrene beads, almost as naturally as we handle objects in our macroscopic world. To demonstrate the impact of this capability, we start by developing TouchCell, an indispensable tool that targets known challenges within the in-vitro fertilisation (IVF) domain. With TouchCell, users are able to uniquely touch and feel cellular forces through tools in real-time, helping them to perform tasks such as micro-injections, biopsies and tool-to-cell interactions with greater control, ease and efficiency. Further, by using haptic technology and robotic techniques, automation of certain cell manipulation tasks is possible. TouchCell will also be able to capture the mechanical properties of cells at a micron scale thought to be of value. By working closely with IVF experts at UCL, we will establish the technical and economic benefits of using TouchCell within the clinic. Expected outcomes also include a number of commercial milestones such as demonstrations of the TouchCell system to potential customers and manufacturers in addition to new IP. Altogether, these activities will provide an entry point in the broader market of micromanipulation for future commercialisation opportunities.

Keywords: 247401
SPATIAL NAVIGATION – A UNIQUE WINDOW INTO MECHANISMS OF COGNITIVE AGEING (AGESPACE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: The Human Mind and its complexity
Countries involved: Germany
Call:  (ERC-2013-StG, 2013)
Start date: 2014-01-01
End date: 2018-12-31
Duration (months): 60.0
Total project cost (EUR): 1318990.0
EU funding (EUR): 1318990.0
Participants: 1
Project status: CLOSED

By 2040, the European population aged over 60 will rise to 290 million, with those estimated to have dementia to 15.9 million. These dramatic demographic changes will pose huge challenges to health care systems, hence a detailed understanding of age-related cognitive and neurobiological changes is essential for helping elderly populations maintain independence. However, while existing research into cognitive ageing has carefully characterised developmental trajectories of functions such as memory and processing speed, one key cognitive ability that is particularly relevant to everyday functioning has received very little attention: In surveys, elderly people often report substantial declines in navigational abilities such as problems with finding one’s way in a novel environment. Such deficits severely restrict the mobility of elderly people and affect physical activity and social participation, but the underlying behavioural and neuronal mechanisms are poorly understood. In this proposal, I will take a new approach to cognitive ageing that will bridge the gap between animal neurobiology and human cognitive neuroscience. With support from the ERC, I will create a team that will characterise the mechanisms mediating age-related changes in navigational processing in humans. The project will focus on three structures that perform key computations for spatial navigation, form a closely interconnected triadic network, and are particularly sensitive to the ageing process. Crucially, the team will employ an interdisciplinary methodological approach that combines mathematical modelling, brain imaging and innovative data analysis techniques with novel virtual environment technology, which allows for rigorous testing of predictions derived from animal findings. Finally, the proposal also incorporates a translational project aimed at improving spatial mnemonic functioning with a behavioural intervention, which provides a direct test of functional relevance and societal impact.

Keywords: spatial navigation
Tangential Impulse Detonation Engine (TIDE)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Aeronautics and air transport
Action type: Collaborative project
Countries involved: Romania,Sweden,Belgium,Moldova, Republic of
Call:  (FP7-AAT-2012-RTD-L0, 2012)
Start date: 2013-08-01
End date: 2016-04-30
Duration (months): 33.0
Total project cost (EUR): 809656.33
EU funding (EUR): 599805.0
Participants: 4
Project status: CLOSED

The proposed project aims at designing, manufacturing and building of a demonstrator for a new engine concept. The new concept replaces the usual turbine of a classical turboengine by a number of Pulse Detonation Combustors (PDC) placed on a disk that rotates under the tangential impulse provided by the exhaust jet of the PDC. The rotating disk is coupled, through a shaft, to the compressor that is placed upstream of the PDC in order to raise its inlet pressure. Two solutions will be considered for the engine propulsion: a propeller, coupled, via a gearbox, to the PDC shaft, or by using the reactive thrust of the PDC exhaust jet, directed at an optimal angle. The PDC inlet with be equipped with aerodynamic valves that control the air entrance into the PDC, thus allowing a significant increase in the detonation frequency, allowing for noise reduction and reduced dimensions. The demonstrator, consisting of a single, fixed, PDC equipped with a fuel injection and ignition system designed for the requirements of the engine concept, will be tested on an experimental facility in order to demonstrate the PDC capability to provide enough power to meet the requirements of the compressor, with sufficient reserve for powering to propel the host aircraft. The project also proposes the design and numerical simulation of the engine compressor, adapted to the requirements of the new engine, most importantly the high vibration load and oscillatory back pressure under which the compressor operates. A last objective of the project is to provide a full definition of the engine constructive solution and a numerical simulation of the flow through the engine that will allow the estimation of the engine performances. The new emerging technology is expected to provide a significant increase in the engine's thermodynamic cycle maximum temperature and efficiency, a drastic reduction in its weight and specific fuel consumption, and a decrease of greenhouse gas emissions.

Keywords: pulse detonation combustor,rotating combustor,new engine architecture
Global Energy Assessment: Dissemination within the EU (GEA DISSEMINATION)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Energy
Action type: Coordination and support actions
Countries involved: Austria
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2012-11-01
End date: 2013-06-30
Duration (months): 8.0
Total project cost (EUR): 176356.0
EU funding (EUR): 128400.49
Participants: 1
Project status: CLOSED

This project will serve to launch the dissemination campaign for the analyses and findings of the Global Energy Assessment (GEA). The proposed funding will support two outreach events in late 2012, in London and Brussels, aimed at beginning a dialogue between GEA experts and the energy stakeholders who are faced with critical energy policy questions, to help develop pathways to energy policies for sustainable global development.The aim of these two events is to ensure that decision makers in EU governments and industries are aware of and able to use the results of this 6-year international project to inform their deliberations. A parallel purpose is to call the attention of the global press to the value of the report's analyses for decision makers and analysts around the world. The requested funding will support the meeting costs of the two meetings, including materials, preparation, travel, video, and report preparation: The one-day dialogue meeting in Brussels will focus on the GEA as a comprehensive energy analysis, offering a framework for considering energy pathways aimed at achieving multiple policy goals. The one-day conference in London will focus on issues related to policies, technologies, and financing for energy access.

Keywords: dissemination energy assessment,providing energy services for sustainable development,energy policy agenda,climate change mitigation,integrated assessment