Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecular basis and the role of phenotypic plasticity in thermal adaptation (Phenoevo)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: ERA Fellowships (HORIZON-WIDERA-2023-TALENTS-02, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 1
Project status: SIGNED

Understanding the mechanisms that generate phenotypic variation and their impact on evolutionary processes is central in modern biology. When faced with adverse environmental conditions populations survive through two distinct processes: phenotypic plasticity (i.e. mechanism in which one genotype produces several different phenotypes depending on the environment) or evolutionary adaptation (i.e. pertinent allele frequency changes in population). While numerous studies have expanded our knowledge of evolutionary principles, the molecular basis and the relative contribution of these two processes to the adaptation is still unknown. Here I propose to tackle this key question by performing experimental evolution and exposing wild-caught D.melanogaster populations to four temperature selection regimes: constant cold temperature, constant hot temperature, fluctuating between hot and cold and optimal temperature as a control. To determine the genetic targets of selection behind the change in thermal tolerance I will perform pooled whole population sequencing of both ancestral and evolved populations. The alleles that increase in frequencies between the ancestral and evolved populations will be further validated to determine their effect on the thermal tolerance. To understand the contribution of phenotypic plasticity to the process of adaptation, I will transfer the evolved populations into a non-selective environment and determine the relative change in thermal tolerance that occurred upon the transfer. Furthermore, to unravel the gene regulatory changes associated with plastic response, I will perform ATAC-seq (chromatin accessibility assay) and RNA-seq (changes in gene expression) of evolved individuals before and after the transfer to the non-selective environment. The inclusion of epigenomic and transcriptomic analysis of the evolved populations will enable us to construct a more holistic picture of adaptation.

Keywords: thermal adaptation experimental evolution phenotypic plasticity gene reglation
INNOVATIVE SOLUTION OF ELECTRO-FOCUS EYEGLASSES (I-SEE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-12-01
End date: 2026-11-30
Duration (months): 24.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Presbyopia is a physiological insufficiency of accommodation associated with aging of the eye (near vision impairment). After the age of 45, everyone gets hit by presbyopia (worldwide 2 billion people) and it worsens with age, affecting visual comfort and life quality. Today, all existing solutions bring compromises and difficulties, even with the most advanced ones: Progressive lenses are intended to provide a seamless increase in optical power to enable clear vision at all distances. In practice, 20% of progressive lens wearers experience heavy vision discomfort, due to a restricted field of vision, distorted vision or inadequate ergonomics. It causes visual fatigue, headaches, eyestrain, postural pain, musculo-skeletal problems (back, shoulders, neck) and trouble in realizing critical multi-tasking activities. Laclarée is developing adaptive autofocus eyeglasses for presbyopia correction. To regain the natural autofocus lost with age and see clearly at all distances, these glasses are equipped with transparent variable fluidic lenses whose correction adapts in real time to the need. Two time-of-flight sensors located on both sides of the front face measure the object's distance, a reliable solution for setting the distance need. This distance data is sent to an electronic unit generating signals to fluidic actuators that control the liquids’ pressure in the lenses. The variable lenses convert this pressure into the desired optical correction, offering true continuous autofocus. Another advantage of electronic control is that the device can be readjusted according to the user precise need, as his/her level of presbyopia evolves over the years. Laclarée lenses also include the necessary refractive correction in terms of hyperopia, myopia and astigmatism, according to the patient's prescription. Laclarée eyeglasses are therefore a class 1 medical device adjusted to each wearer. Laclarée owns its technology, well protected by patents and trade secrets.

Keywords: presbyopia,autofocusing,adaptive,smarteyeglasses,fluid filled lens,optical quality,life quality,silver economy,clear and natural vision,straightforward use,durable wear,inconspicuous look
WORLD´S FIRST ZERO-EMISSION THERMAL PLASTICS: PIONEERING SUSTAINABLE MATERIALS (H2GO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Armenia
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2490000.0
EU funding (EUR): 2490000.0
Participants: 1
Project status: SIGNED

At H2Go, we are addressing one of the most critical environmental challenges of our time: the carbon-intensive production of thermoplastics, a material integral to industries ranging from automotive to packaging. The production of traditional thermoplastics relies heavily on fossil fuels, contributing significantly to global greenhouse gas emissions. The demand for sustainable alternatives is growing rapidly, driven by both regulatory pressures and consumer demand for greener products. This challenge is particularly acute in Europe, where 85-90% of low-carbon thermoplastics are imported, creating vulnerabilities in supply chains and increasing the region’s carbon footprint. Our innovation at H2Go offers a groundbreaking solution to these challenges: the world's first zero-emission thermoplastics, produced through a fully integrated process that combines CO2 capture, green hydrogen production, and catalytic conversion. By capturing CO2 emissions directly from industrial sources and converting them into green methanol, we create the building blocks for high-value thermoplastics, entirely free of carbon emissions. Our modular Proton Exchange Membrane (PEM) electrolyzers, operating at over 70% efficiency, are powered by renewable energy, ensuring that every step of our process aligns with the European Union's ambitious environmental goals. The benefits of our innovation are profound. Our green thermoplastics not only reduce reliance on fossil fuels but also provide a scalable, economically viable alternative that supports Europe’s transition to a circular economy. By 2030, we aim to fully operationalize production plants across Europe, contributing to a significant reduction in the continent’s carbon footprint.

Keywords: zero carbon thermoplastics,co2 capture,green hydrogen production,catalytic conversion,green methanol,modular pem electrolyzers,carbon neutral production
Saving the Kashmirian Sanskrit Heritage (K-S-H-Raksa)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2499250.0
EU funding (EUR): 2499250.0
Participants: 1
Project status: SIGNED

The importance of Kashmirian Sanskrit Literature was realised by scholars only in the late 19th century, when the literary canon and historiography of Sanskrit Literature in the Indian subcontinent had already taken shape. Texts and whole genres that were unique to Kashmir, as political history, were not properly recognised and led to a distorted view of South Asian literature. Much has changed, especially in the last decades, but the latest exodus and dissipation of the Kashmirian Hindu community is bound to have a lasting negative effect on such studies. A major effort to rescue the still unpublished and often unknown highlights of Kashmirian Sanskrit literature from oblivion is warranted. In the present project a team specialising in editing Kashmirian texts will make a larger number of carefully selected texts accessible in first editions by utilizing the vast reservoir of manuscript scans that has sprung up online in recent years. Previous work on unknown texts from newly opened up archives has suggested that much more is to be discovered. One spectacular example would be a 17th century piece of visual poetry from Kashmir, the ``Wish-fulfilling Tree'', which is breaking several international records (for instance, for using thirty languages in its intexts), but has remained completely unknown until very recently. The project will produce a careful selection of previously unknown Kashmirian Sanskrit works in ten volumes. They will be accompanied by studies of their literary, religious or philosophical aspects, from which their significance for the history of Sanskrit Literature can be grasped. The project is a bold attempt to drastically improve the basis of scholarship in Kashmirian Sanskrit, and we shall argue that as a result new genres in Sanskrit literature need to be defined.

Keywords: indology,sanskrit studies
Cavity quantum materials (CAVMAT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-02-01
End date: 2029-01-31
Duration (months): 60.0
Total project cost (EUR): 1951063.0
EU funding (EUR): 1951063.0
Participants: 1
Project status: SIGNED

Light-matter coupling has the potential to modify functional properties of quantum materials to yield the tunability required for quantum-technological applications. However, light-matter control concepts, such as Floquet engineering and light-induced phase transitions, suffer from the requirement of strong laser driving and the lack of coherence on long time scales. Overcoming these key limitations through advancing the infant field of cavity quantum materials is the central objective of CAVMAT. The main hypothesis behind CAVMAT is that cavity materials engineering combines the efficiency of strong-light matter coupling in cavities with the flexibility of Floquet engineering of macroscopic quantum many-body phenomena. CAVMAT aims to explore and expand this new frontier with a combined theoretical-computational effort. The three key objectives of CAVMAT are: (i) To establish cavity-driving schemes that successfully bridge the gap between quantum cavity and semiclassical many-photon Floquet limits. (ii) To propose realistic cavity quantum materials platforms providing guidance for next-generation experiments. (iii) To develop and combine numerical methods that can treat the relevant nonequilibrium electron-polariton problems at short and long time scales. These objectives will be tackled in three work packages, namely WP 1: quantum Floquet engineering, WP 2: plasmonic superconductivity, and WP 3: excited states by design. The proposed work goes well beyond state-of-the-art in both nonequilibrium quantum many-body systems and quantum optics, and its success will be groundbreaking through providing microscopic underpinnings for pathways towards versatile solid-state platforms for cavity and Floquet physics.

Keywords: floquet engineering,ultrafast materials science,quantum optics
How to minimize the ecological footprint for functional electronics? (ECOTRON)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Netherlands,Finland,France,Spain,Belgium,Italy,Czechia
Call: Functional electronics for green and circular economy (RIA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 4999000.25
EU funding (EUR): 4999000.25
Participants: 11
Project status: SIGNED

A growing desire for continuous data collection, real time information and connectivity has resulted in increased demand for electronic functionalities that are fully integrated in everyday objects. Consumer electronics, healthcare, wearable electronics, IoT and smart packaging are examples of market segments that follow this trend. Printed circuit boards (PCBs) are the state of the art to create electronic functions; however, this technology creates an ever increasing strain on the environment because recycling and/or dismantling of the PCB can hardly be done. A radical sustainability improvement requires disruptive electronics manufacturing processes, technologies and materials. Printed electronics are more environmentally friendly than the traditional PCB, due to their additive character (printing instead of etching), the absence of chemical etching materials, low energy demanding process conditions and possibility for recovery or re-use of substrates and (metallic) inks. Thereto, in ECOTRON, flexible, organic & printed electronics are advanced through a multidisciplinary approach involving biobased materials, innovative (print) processes, and device and module dismantling technologies. Furthermore, recycling technologies and standards will be developed that are eventually integrated in a process design for a printed electronics recycling plant. Simultaneously, the lifetime of printed electronics is improved for larger implementation of printed electronics into everyday products. ECOTRON will create use-case demonstrators in existing state-of-the-art electronics products in consumer electronics, smart packaging, healthcare and wearable electronics market segments to demonstrate the potential environmental enhancements.

Keywords: flexible,organic and printed electronics,recycling technologies
VELES Excellence Hub - Strengthening the South-East Europe Smart Health Regional Excellence and Boosting the Innovation Potential (VELES)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Bulgaria,Greece,Spain,Romania,Germany,Sweden,Cyprus
Call: Excellence Hubs (HORIZON-WIDERA-2022-ACCESS-04, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 4750000.0
EU funding (EUR): 4750000.0
Participants: 16
Project status: SIGNED

Smart Health is EU Strategic Value Chain that contributes to growth, jobs and competitiveness. Health Data is the main enabler for the value chain, but it also depends on cutting edge technologies - AI, cloud computing, IoT, to integrate the dispersed knowledge and support innovative healthcare solutions and services. EC sets the creation of a European Health Data Space as a main priority, to promote better exchange and access to health data. On a regional level, the RIS3 strategies of the involved widening countries - Bulgaria, Romania, Greece and Cyprus emphasize the need for based on Big Data, AI and IoT digitalized healthcare, to enable personalized medicine, informed decisions, and improved disease prediction. RIS3 strategies also outline the need for more funding for R&I, policy coherence and development of territorially join innovation strategies. A cross country coordinated approach is needed to align the separate endeavours towards an Excellent South-East Europe Smart Health Innovation Ecosystem enabled by a Regional Smart Health Data Space. VELES raises the level of innovation excellence in the South-East EU through creating a sustainable place-based innovation ecosystem, enabled by Regional Smart Health Data Space, including novel transformational framework, R&I and investment strategy and action plan for research, development and adoption of innovative and secure digital solutions that underpin the delivery of sustainable healthcare services. The Regional Smart Health Data Space will be demonstrated through the design of 4 interrelated pilots on Cancer treatment (Greece); Personalised/precision medicine of Alzheimer (Bulgaria); Cerebral tumours (Romania) and Dementia (Cyprus). The aim of VELES is to foster health data sharing regional and national strategies, to secure improved clinical practice, to preserve patient’s privacy and to empower citizens’ smart healthcare through access to innovative, cyber secure and data driven digital health services.

Keywords: smart health,data spaces,excellence hubs,innovation ecosystems
Unraveling mechanisms of immunotherapy resistance through biomarker profiling in triple-negative breast cancer (Bio3XBRIT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

Breast cancer remains a major public health issue, being the leading cause of cancer deaths among women in France, with around 58,459 new cases and 12,146 deaths reported in 2018. There are three main types: hormone receptor (HR)-positive (75-80% of cases), HER2-positive (15% of cases), and triple-negative breast cancer (TNBC) (15-20% of cases). Standard treatment involves surgery, radiotherapy, chemotherapy, hormone therapy for HR-positive cases, and targeted anti-HER2 therapy for HER2-positive cases. Recently, immunotherapies like pembrolizumab (an anti-PD1 antibody) have been approved for TNBC patients, in combination with chemotherapy. However, immune checkpoint inhibitors are associated with immune-related adverse events (irAEs) due to generalized lymphocyte activation, which can affect any tissue and even lead to death in severe cases. There is an urgent need to better understand the anti-tumor immune response to reduce toxicity, improve immuno-oncology strategies for TNBC, and broaden their application to other breast cancer types. Additionally, treatment resistance is a significant challenge, with unknown reasons limiting the number of patients achieving complete response. The proposed project aims to advance breast cancer immunotherapy by developing a comprehensive molecular approach to discover TNBC immunotherapy biomarkers of treatment resistance and irAE development, thank to the access to TNBC patient cohorts. Molecular characteristics and clonotype dynamics of T cells (CD8+, CD4+ Tconvs, and Tregs) at the single-cell level during anti-PD1 treatment, will be correlated with tumor transcriptomic data and clinical data. Analysis of an existing cohort of 83 TNBC patients treated with pembrolizumab and neoadjuvant chemotherapy will uncover aspects of the anti-tumor T-cell response, T-cell specificity, and identify novel biomarkers of resistance and toxicity, as well as targets for therapeutic options.

Keywords: immunotherapy,therapy resistance,biomarkers
Triboelectric energy generators for self-powered medical implants (TriboMed)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1998273.0
EU funding (EUR): 1998273.0
Participants: 1
Project status: SIGNED

Based on intense research efforts in the fields of technology development and materials science, a new generation of medical devices has flourished. But this medical technology still relies on conventional energy sources (bulky batteries). These batteries typically have shorter lifetimes than the implant itself, meaning limitations on patients´ activities, infections and additional surgeries. In an ideal scenario, active implantable medical devices (AIMDs) would be powered using integrated and fully implantable energy suppliers, not needed to be recharged or replaced. An integrated implantable energy harvesting device to power AIMDs is the crucial missing component that would unlock this future. TriboMed aims to implement triboelectric energy generators (TENGs) for powering AIMDs, taking vagus nerve stimulation (VNS) as proof-of-concept. I will show that TENGs can be produced at larger scale, while being miniaturized and tuned, supplying energy levels suitable for driving stimulation implants. By coupling to a supercapacitor, I aim to develop a fully integrated energy autonomous VNS implant on a conformable and biocompatible substrate. My approach is timely and innovative because it responds to the increasing needs of energy harvesting and comes when the maturity level reached by thin films technologies allows to start working on device integration. My background in materials science and my current experience in device technology provides me with the tools necessary for the successful development of TriboMed. I have the privilege to be working at the forefront of the biomedical research, affording insight into the latest achievements and emerging requirements of VNS technology. TriboMed will unlock the use of triboelectricity for feeding other AIMDs and beyond, on the Internet of Things. Turning the medical implants into self-powered systems will broaden the acceptance of the neuromodulation therapies, with a life-changing impact on a very large patient population.

Keywords: thin film technology development and integration,materials engineering,biomedical applications,triboelectric generators development