Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Directed Evolution of Novel Artificial Metalloenzyme Platforms for Biocatalysis (ArtMetBio)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Artificial metalloenzymes have emerge as a fusion of synthetic and biological catalysts for environmentally friendly synthesis. These hybrid catalysts are created by tethering a catalytic metal ion or cofactor to a protein scaffold. Optimized artificial metalloenzymes have the potential to harness the advantages of both systems, inheriting the versatility of synthetic catalysts and the efficiency and robustness of enzymes. New tools, however, are required to realize the potential of artificial metalloenzymes. The objective of the ArtMetBio project is to create novel platforms for artificial metalloenzymes that optimize catalytic performance and versatility via increased cooperation between the synthetic and biological components. Now, more than ever, green catalysis is a crucial global endeavor. Our growing ability to evolve enzymes enables the use of new, unexpected protein scaffolds, opening the door to new innovative platforms. Taking advantage of directed evolution methods, this proposal outlines a strategy for repurposing two well characterized protein scaffolds to create artificial metalloenzymes for in vivo metathesis, a canonical reaction in synthetic chemistry not found in nature. Aim 1 of the project is to optimize metathesis-catalyzing enzymes, coined metathases, through directed evolution. Aim 2 will apply these metathases to engineer a biocatalytic cascade for in vivo synthesis of high-value privileged compounds. The proposed systems differ from the current state-of-the art—streptavidin and heme artificial metalloenzymes—because they are monomeric, non-toxic, and highly modular, enabling wide catalytic versatility. The proposed action has the potential to provide unique, versatile tools for synthesis and biocatalysis.

Keywords: artificial metalloenzymes,directed evolution,biocatalysis
Efficient Industrial Air Compressor (Spira)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2020-01-01
End date: 2020-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Spira Energy develops a completely new type of air compressor that will revolutionize and dominate the market for industrial air compressors. Context Compressed air (CA) is a vital and versatile tool for industrial businesses. CA can be used for instrumentation, control, hand tools and to drive processes. 70% of all manufacturing facilities use some form of CA. It is estimated that 10% of global industrial electricity consumption is used to compress air. Problem CA is currently one of the least efficient forms of energy. At best, new air compressors achieve 50% efficiency, but they quickly deteriorate. Efficiency drops to 35% in 10 years. Energy is lost through heat generation, leaks and poor maintenance. Our Solution We have developed and patented Spira, a disruptive air compressor with an efficiency above 80%, which uses water as pistons. This keeps the compression process cool and reduces wear and tear, meaning high efficiency is maintained throughout the lifetime of the compressor. Our compressor offers • Improved energy efficiency • Reduced maintenance costs and improved reliability • Improved working environment • Improved sustainability Traction First customer provides 150 000€ for a installation at 36kW size. Project We aim to use the SME instrument to help us scale up our initial prototype to commercial readiness, and to demonstrate the effectiveness of Spira to the industry. The phase I project will confirm the market interest in our product and the proposed business model, while identifying the key European markets to target when we start commercializing Spira in 2022. Impact The air compressor market was worth an estimated 23 billion € in 2016. Spira has the potential to reduce production costs of compressed air by 45%. This could lower equivalent CO2 emissions in Europe by 10 million tons every year. Spira provides a new disruptive technology with superior competitive advantages that could boost jobs, growth and prosperity in Europe.

Keywords: industrial air compressors
Advanced safety architecture and components for next generation TCMS in Railways (Safe4Rail-3)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Austria,Germany,Germany,Germany,Spain,Italy,Spain,Sweden,Belgium,France
Call: Network and end-device equipment for the validation of the next generation of TCMS (TD1.2) (H2020-S2RJU-OC-2020, 2020)
Start date: 2020-12-01
End date: 2023-11-30
Duration (months): 36.0
Total project cost (EUR): 6112057.86
EU funding (EUR): 4585831.39
Participants: 12
Project status: SIGNED

Safe4RAIL-3 and its activities will be based on the development of three technological pillars aimed at advancing the maturity of the technologies and devices for the next generation for Train Control and Monitoring System (TCMS), in order to pass from prototypes level to TRL 6/7: (1) Development of the Drive-by-Data (DbD) devices in the train network, i.e. Ethernet Train Backbone Nodes, Car Switches and End Devices, using Time-Sensitive Network technology for adding determinism to TCMS communications.(2) Development of high TRL wireless devices and antennas that are suitable for Wireless TCMS (WLTB and WLCN domains), along with analysis of antenna installation based on ray-tracing simulations and on-site validations to identify the most optimal antenna locations and radiation patterns in the different wireless TCMS domains (3) Integration of a Heating, Ventilation and Air Conditioning functionality on top of a Functional Distribution Framework platform and a DbD communication layer, taking advantage of the expertise obtained from automotive industry specialized on AUTOSAR. Safety and Security assessments for these technological developments will be analyzed and studied based on the upcoming standardization. All these technological developments will be further validated in two real demonstrators that will be set up by the Shift2Rail CFM project and will also contribute to standardization. These results will increase the flexibility and reliability of the TCMS communications, reduce development and maintenance costs, and achieve novel train functionalities, paying special attention to manufacturer interoperability and the availability of multiple sources. The consortium consists of 10 partners with specific industrial profiles and expertise in key technologies from 7 European countries, including 8 industrial partners, 2 academic partners. Such an industry-oriented consortium has been considered crucial to bring the selected technologies to higher TRL up to TRL-7.

Keywords: next generation tcms,next generation wireless tcms,deterministic communications,autosar,simulation framework,iec 61375,safety and security assessments
Semi-Autonomous ProtoTissues capable of photo-Mechano-Chemical transduction (SAPTiMeC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 176655.84
EU funding (EUR): 176655.84
Participants: 2
Project status: SIGNED

Recently, researchers in the field of bottom-up synthetic biology have developed different models of non-living cell-like entities, termed protocells. Protocells are designed to mimic basic aspects of living cells and have potential applications in various emerging technologies. Prototissues comprise networks of protocell consortia that communicate and display synergistic functions. Though the current designs contribute much to the development of bottom-up synthetic biology, they lack robustness and the complexity required to perform higher-order functions. The aim of this proposal is to advance the prototissue design to create prototissues capable of higher-order functions (i.e. photo-mechano-chemical transduction). The prototissues will be created by stratifying and patterning populations of specialised protocells. As a result, the prototissue will be able to self-regulate the amount of luminous energy received from the environment by opening and closing cyclically. This movement enables the prototissue to tune its endogenous photocatalytic reactivity, producing waves of an output chemical signal. The expertise of the applicant in photochemistry, materials and nanomaterials chemistry will be applied to the emerging field of prototissue engineering, area in which the hosting supervisor is an emerging leader. The approach will be focussed on the generation of macroscopic free-standing prototissue sheets with complex architectures. This process will be used to create phototropic prototissues upon exploiting photoresponsive hydrogels encapsulated in their building blocks. The resulting phototropic prototissues will be modified in order to contain building blocks with photocatalytic synthetic proto-organelles. Collectively, the outcome of this proposal will: kickstart a new area of bottom-up synthetic biology; provide a new approach to the construction of out-of-equilibrium systems; and deliver new materials with applications in tissue engineering and soft robotics.

Keywords: out of equilibrium,self regulating,photoactuators,soft robotics
An exosome-based therapeutic approach against chronic inflammation (InflaCare)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Greece
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2021-01-01
End date: 2022-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

DNA damage triggers the activation of innate immune signaling leading to chronic inflammation and the premature onset of e.g. rheumatoid arthritis, diabetes, metabolic diseases and neurodegenerative disorders in man. Based on our ERC consolidator program DeFiNER, we recently discovered that persistent DNA damage triggers the innate immune system stimulating broad inflammatory and antiviral immune countermeasures that lead to chronic inflammation and the premature onset of severe metabolic complications and neurodegeneration in mice. Here, we propose a sophisticated a therapeutic anti-inflammatory strategy aimed at lowering chronic inflammation in preclinical animal models with pronounced metabolic diseases or neurodegeneration. Unlike available anti-inflammatory therapies, the proposed therapeutic approach is non-immunogenic, allows the therapeutic cargo to circulate for extended periods within the body and to cross the blood brain barrier with no biocompatibility complications and minimal to no inherent toxicity issues in mice. This novel strategy provides, therefore, the means towards an innovative medicine that will effectively address real but unmet therapeutic needs for a wide range of devastating diseases associated with chronic inflammation.

Keywords: dna damage,chronic inflammation,age related diseases,exosomes,preclinical animal models
Boosting the implementation of participatory strategies on separate paper collection for efficient recycling (IMPACTPapeRec)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Coordination and support actions
Countries involved: Germany,Austria,Spain,Spain,Germany,Germany,Spain,Belgium,Poland,Romania,Bulgaria,Bulgaria,Romania,Serbia,Bulgaria,Croatia,France,France
Call: Raw materials partnerships (H2020-WASTE-2015-one-stage, 2015)
Start date: 2016-02-01
End date: 2018-01-31
Duration (months): 24.0
Total project cost (EUR): 1486782.5
EU funding (EUR): 1486782.5
Participants: 26
Project status: CLOSED

The European paper industry is at the core of the bioeconomy, using wood, a renewable material, and Paper for Recycling (PfR) as its main raw materials for producing paper products. This industry is a strategic sector in the EU economy, actively contributing to the re-industrialisation of Europe. Currently, the production of paper and board in the EU is 91 tonnes per year, while PfR represents 63%. The contribution of PfR has increased over the last few years (from 25 t to 40 t). This increase in the availability of PfR has not taken place in all EU states, and this is especially true in Eastern European countries. Besides, although high collection rates are achieved, the quality of this material does not always meet the requirements of paper recycling. Both facts make difficult to keep up with the increases in PfR collection rates observed over the last few years if specific actions are not taken. IMPACTPapeRec aims to put Europe at the forefront of PfR collection, ensuring raw material procurement from mainly European sources through an innovative approach based on the participation of the whole paper value chain including citizens and municipalities, which is also open to other sectors. Main objective is to provide an innovative and common knowledge platform, which will enable present and future cooperation. Analysis on best practices in PfR collection and assessment procedures are delivered, considering specific local conditions. They will encourage reliable decisions and make solutions available to decision-makers ensuring the procurement and supply of PfR in Europe through the improvement of municipal paper collection. Medium-long results are: increases in PfR collection (up to 75%); 1.57 Mt/year and raw material savings of €385 million. This proposal has positive support from the EU of the commitment approved within the EIP on raw materials “IMPACT - Introduction and Improvement of Separate Paper Collection to avoid landfilling and incineration”.
Endothelial Gluconeogenesis: a novel target for tumor anti-angiogenesis? (EC GNG metabolism)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2019-02-13
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

Angiogenesis promotes tumor progression and metastasis; unfortunately current anti-angiogenic strategies targeting endothelial growth factors suffer from limited efficacy and toxicity. The host laboratory pioneered the novel concept that blood vessel forming endothelial cells (ECs) reprogram their metabolism to become glucose-addicted and rely on glycolysis to generate ATP required for angiogenesis. Furthermore, to increase biomass production and maintain redox homeostasis, ECs shunt glycolytic intermediates into glycolysis side-pathways. Further ECs diverge from pre-existing blood vessel into avascular tissue, the scarcer external glucose levels will become. Currently, how ECs maintain the generation of glycolytic intermediates under such conditions remains unknown. One possibility is the de-novo synthesis of these intermediates through gluconeogenesis (GNG). To date, nothing is known about GNG metabolism in ECs, which underscores the novelty of my proposal. GNG is particularly interesting since preliminary findings indicate that ECs express all enzymes involved in GNG, and impairing this pathway decreases EC proliferation and sprouting. Therefore, through a multi-angled approach, I will unravel the role of GNG in ECs and uncover its contribution to blood vessel sprouting both in normal and pathological angiogenesis. Ultimately this project will explore whether blocking GNG may inhibit pathological angiogenesis (e.g. cancer) and translate my findings into therapeutic strategies.

Keywords: angiogenesis,endothelial cells,anti angiogenic therapy,vascular biology,gluconeogenesis
Smart Toolbox for Engaging Citizens into a People-Centric Observation Web (SCENT)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Developing comprehensive and sustained global environmental observation and information systems
Action type: Innovation actions
Countries involved: Israel,Ireland,Italy,Italy,Greece,Romania,Romania,Netherlands
Call: Demonstrating the concept of 'Citizen Observatories' (H2020-SC5-2015-two-stage, 2015)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 3882487.5
EU funding (EUR): 3264675.0
Participants: 11
Project status: CLOSED

Whilst citizen participation in environmental policy making is still in its infancy, there are signs of a growing level of interest. The majority of citizens, though, both as individuals and as groups often feel disengaged from influencing environmental policies. They also remain unaware of publicly available information, such as the GEOSS or Copernicus initiatives. The SCENT project will alleviate this barrier. It will enable citizens to become the ‘eyes’ of the policy makers by monitoring land-cover/use changes in their everyday activities. This is done through a constellation of smart collaborative technologies delivered by the SCENT toolbox in TRLs 6-8: i) low-cost and portable data collection tools, ii) an innovative crowd-sourcing platform, iii) serious gaming applications for a large-scale image collection and semantic annotation, iv) a powerful machine-learning based intelligence engine for image and text classification, v) an authoring tool for an easy customization by policy makers, vi) numerical models for mapping land-cover changes to quantifiable impact on flood risks and vii) a harmonization platform, consolidating data and adding it to GEOSS and national repositories as OGC-based observations. SCENT will be evaluated in two large scale demonstrations in Kifisos Attica and Danube Delta. Our consortium covers the complete stakeholder chain: industries in machine learning (IBM), SMEs in crowd-sourcing (U-Hopper), gaming (Xteam) and awareness raising (Carr), leading research institutes with expertise in hydrodynamic modelling (UNESCO-IHE), data harmonization and authoring tools (ICCS) and environmental monitoring (DDNI), NGOs at the pilot sites (HRTA, SOR) and policy makers/public bodies (Region of Attica). The SCENT initiative will go beyond the current project and form a European-wide citizen movement, created and fostered by the SCENT stakeholders, that will ensure its sustainability and its complementarity with existing citizen partnerships.

Keywords: citizen observatories,serious games,crowd sourcing,observation web,geoss,flood risk maps
International, inter-sectoral and inter-disciplinary Doctoral Training Programme to Aix-Marseille University (DOC2AMU)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy,France,France
Call: Marie Skłodowska-Curie Co-funding of regional, national and international programmes (COFUND-DP) (H2020-MSCA-COFUND-2015, 2015)
Start date: 2016-12-01
End date: 2021-11-30
Duration (months): 60.0
Total project cost (EUR): 4708800.0
EU funding (EUR): 2354400.0
Participants: 16
Project status: CLOSED

DOC2AMU raised out of the willpower of the Provence Alpes Cote d’Azur key regional actors in Research and Innovation to offer to the most promising early stage researchers an international, inter-sectoral and inter-disciplinary innovative doctoral training programme. The excellence is ensured not only by the research ecosystem of Aix-Marseille University but also through the open, transparent, merit-based, impartial and equitable selection process set up to assess the perfect match between the proposed doctoral projects and the ESRs. Further to ensure the best career perspectives after ESR’s’ graduation, DOC2AMU set up an original training programme offering a training scheme combining options of the 3 international/inter-sectoral and interdisciplinary dimensions, including a comprehensive package of transferable skills training, along with a specific mentoring scheme involving an academic Supervisor, a non-academic and/or international tutor(s) and a Scientific & Training Supervisory Committee. Apart from the recruitment of 30 ESRs, it is expected that DOC2AMU will enhance skills of AMU ESRs including transferrable ones; upgrade AMU doctorate’s curriculum, by generalizing the innovative Doctorate Principles as a standard for all Doctoral training in AMU; reinforce AMU capacities to host talented international researchers in high standard working and improved employment conditions; intensify the cooperation and the alignment of AMU Human Resources practices between key regional academic and non-academic research and innovation players; develop new synergies on the regional territory; strengthen the innovative aspects of the Regional Doctoral programme and disseminating HR and training good practices in other Universities and Research organisations in PACA; and prioritize research projects focusing on the regional Research and Innovation Strategies for Smart Specialization strategies to create a regional leverage in terms of knowledge and innovation.

Keywords: triple i dimension,aix marseille university s excellence,innovative doctoral training,carrer development,smart specialisation