Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
REVealing the Effects of Star-planet Interactions (REVErSI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-12-01
End date: 2024-11-30
Duration (months): 36.0
Total project cost (EUR): 259398.72
EU funding (EUR): 259398.72
Participants: 1
Project status: SIGNED

Exoplanetary science has thrived in the last three decades; we now know of thousands of new worlds orbiting other stars, and we are investing new ground-based and space facilities in characterizing them. However, the interaction between planets and their host stars is still poorly understood. In this new, exciting field, REVErSi will offer a comprehensive theoretical study of star-planet interactions using innovative analytical models and state-of-the-art numerical simulations. REVErSI will study the tidal, and magnetic interactions of the most common type of exoplanets, Hot Jupiters (HJs), with low-mass stars: M-dwarfs and Solar-like stars. HJs lie close enough to their host star to be magnetically interacting with it. We will study the effect of this interaction on the stellar dynamo, and the magnetic cycle of the star, analytically and numerically. In parallel, we will investigate the role of planet-induced tides on the magnetic activity of the star. Finally, we will examine the variation of the stellar activity as a means of estimating exoplanetary magnetic fields. This contribution will provide one of the very few currently feasible methods to estimate exoplanetary magnetic fields.

Keywords: stellar activity cycles,stellar magnetism,star planet interaction
European Climate and Energy Modelling Forum (ECEMF)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Robust decision making and public engagement
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Australia,Austria,Germany,Germany,Italy,Poland,Greece,Sweden,France,Netherlands,Netherlands
Call: European Energy and Climate Modelling Forum (2020-2024) (H2020-LC-SC3-2020-NZE-RES-CC, 2020)
Start date: 2021-05-01
End date: 2025-04-30
Duration (months): 48.0
Total project cost (EUR): 5011580.0
EU funding (EUR): 4999563.0
Participants: 15
Project status: SIGNED

The aim of ECEMF is to provide the knowledge to inform the development of future energy and climate policies at national and European levels. In support of this aim, ECEMF proposes a range of activities to achieve five objectives and meet the four challenges set out in the call text. ECEMF’s programme of events and novel IT-based communications channel will enable researchers to identify and co-develop the most pressing policy-relevant research questions with a range of stakeholders to meet ambitious European energy and climate policy goals, in particular the European Green Deal and the transformation to a climate neutral society. Answers will be provided by the first inclusive and open full-scale model comparison exercise on achieving climate neutrality in Europe, including from the outset over 20 models and 15 top research groups, to produce a coherent and relevant evidence-base for energy and climate policy impact assessment. ECEMF’s evidence-base will support the development of policy-relevant insights which will be communicated to and discussed with the key decision makers via a range of novel methods, including interactive embeddable visualisation blocks, policy briefs, workshops and high-profile events. This loop of knowledge co-production stands on two pillars. First, ECEMF will advance the state-of-the-art of energy and climate modelling by enabling sharing of: input data using open standards, methods for model comparison building on the vast experience of the consortium, scientific software tools such as the IIASA scenario explorer and hands-on training for researchers. Second, ECEMF will be established as a long-term, open and welcoming European focal-point for researchers and policy makers with unparalleled international connections to the EMF, JMIP, IAMC and IPCC. Through extensive links to ongoing H2020 projects, research and policy communities & networks ECEMF will reduce fragmentation of the European energy and climate research landscape.

Keywords: energy climate model comparison
Gut-Brain Communication in Metabolic Control (GuMeCo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Communication between the gut and the brain is essential for metabolic function. Sensory afferent neurons are key gut-brain connectors that monitor gastrointestinal (GI) tract organs, including the stomach, the duodenum, the liver, and the portal vein area, and thereby critically contribute to systemic energy and glucose homeostasis regulation. Disruption of this neural gut-brain communication develops in obesity and correlates with overeating, body weight gain, and insulin resistance. However, the relevant sensory neuronal populations innervating the GI tract organs along with the pertaining underlying metabolic neurocircuitry still remain to be elucidated. To date, advances in this field have been impeded by the challenges associated with targeting distinct sensory neurons of vagal and spinal origin in a cell-type and organ-specific manner, thereby making the accurate determination of their metabolic function highly difficult. Thus, the proposed comprehensive research program will employ a combinatorial set of modern molecular systems neuroscience tools and novel mouse genetic approaches to (1) elucidate the role of specific sensory neurons in feeding behavior and glucose metabolism, (2) determine the functional metabolic neurocircuitry of GI tract-innervating vagal and spinal afferents in an organ-specific manner, (3) study the effects of obesity on their transcriptomes, and (4) map their functional connectivity as well as synaptic adaptions to downstream brain sites. Collectively, the overarching goals of these four autonomous but complementary projects are to gain greater insights into the integral components of sensory neurons as gut-brain connectors in controlling metabolism as a first step to developing new therapies to treat obesity.

Keywords: neural control of metabolism,sensory afferent neurons
Identifying the proteins of the cochlear mechanoelectrical transduction machinery that are also involved in the development of auditory cortex interneurons. (DEVINAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-07-01
End date: 2021-11-04
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

My long-term goal is to advance our understanding of the development and maturation of cortical neuronal microcircuits. My PhD focused on the role of adult brain plasticity in psychiatric diseases. I will now perform postdoctoral studies in the laboratory of Prof. Christine Petit, where a population of GABAergic interneuron precursors co-expressing two cadherin-related proteins, cdhr15 and cdhr23, from their birth in the medial ganglionic eminence to their final destination in the auditory cortex, was recently identified. Cdhr15 and cdhr23 and eight other proteins have been implicated in mechanoelectrical transduction in auditory sensory cells. In the brain, defects of cdhr15 or cdhr23 result in a deficit of parvalbumin-expressing interneurons in the auditory cortex only, and susceptibility to audiogenic seizures. Heterozygous Cdhr15+/- or Cdhr23+/- mice have smaller numbers of parvalbumin interneurons, but with considerable interindividual variability. The work proposed here aims to provide insight into the mechanisms involved in the development of this newly identified population of interneurons and their integration into the cortical microcircuits of the auditory cortex. I will address the following three questions: 1) Which other mechanoelectrical transduction proteins of sensory cells are involved in the development of interneurons in the brain? 2) What roles do cdhr15 and cdhr23 play in the migration of interneurons and their integration into the auditory cortex? and 3) Is the monoallelic expression of Cdhr15 and Cdhr23 responsible for the interindividual variability in Cdhr15+/- and Cdhr23+/- mice? This project will shed light on the extent to which people suffering from hereditary forms of deafness also suffer from cortical deficiencies, providing a scientific basis for improving auditory rehabilitation in patients.

Keywords: parvalbumin interneurons,cadherin related proteins,neuronal migration,deafness,usher syndrome
Environmentally Friendly Recycled Plastic Floors in Containers (EPIC)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Sweden
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The objective of this project is to assess the feasibility of EPIC (Environmentally-friendly Plastic In Containers) – an environmentally-friendly alternative to the currently used container floors. Shipping containers are the backbone of global trade, an industry worth more than USD 18.5 trillion. It is due to shipping containers that globalisation has become a reality, products of all shapes, sizes, and functions can be delivered to every corner of the world. However, for many years the industry has faced difficulties in production of environmentally-friendly, sustainable container floors. The most commonly used material for container floors is hardwood. Hardwood is a resource that is becoming depleted and in danger of disappearing due to illegal logging in efforts to meet industrial demands. The industry has acknowledged this growing problem and is making efforts to use responsibly sourced materials. However, it is difficult to meet the growing demands with responsibly sourced hardwood alone. This industry is extremely price sensitive, companies are focused to maximise profits. As a result the cheaper bamboo has been gaining ground over the past 5 years and is now almost 50% of the market. However, bamboo required special treatment and lamination to fulfil the task of a container floor, these processes are often harmful leading to occupational hazards for labourers. Norcomp’s goal is to bring it’s innovation, EPIC, to market as the new ‘gold-standard’ in the shipping industry. EPIC floors are made of 100% re-cycled waste plastic that is processed and re-moulded for use as container floors. EPIC floor are physically and mechanically equivalent – if not superior to – hardwood floor. Thus, improving the industry and addressing the global need to reducing the waste plastic burden on our environment. As EPIC floor enter mass production they will be a cheaper, environmentally-friendly, and safer alternative to hardwood and bamboo container floors.

Keywords: environment,waste plastic,container,container floor,shipping,global trade,illegal logging prevention
Bringing into focus the cellular dynamics of the plant growth hormone gibberellin (CELL HORMONE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 1499616.0
EU funding (EUR): 1499616.0
Participants: 1
Project status: CLOSED

During an organism’s development it must integrate internal and external information. An example in plants, whose development stretches across their lifetime, is the coordination between environmental stimuli and endogenous cues on regulating the key hormone gibberellin (GA). The present challenge is to understand how these diverse signals influence GA levels and how GA signalling leads to diverse GA responses. This challenge is deepened by a fundamental problem in hormone research: the specific responses directed by a given hormone often depend on the cell-type, timing, and amount of hormone accumulation, but hormone concentrations are most often assessed at the organism or tissue level. Our approach, based on a novel optogenetic biosensor, GA Perception Sensor 1 (GPS1), brings the goal of high-resolution quantification of GA in vivo within reach. In plants expressing GPS1, we observe gradients of GA in elongating root and shoot tissues. We now aim to understand how a series of independently tunable enzymatic and transport activities combine to articulate the GA gradients that we observe. We further aim to discover the mechanisms by which endogenous and environmental signals regulate these GA enzymes and transporters. Finally, we aim to understand how one of these signals, light, regulates GA patterns to influence dynamic cell growth and organ behavior. Our overarching goal is a systems level understanding of the signal integration upstream and growth programming downstream of GA. The groundbreaking aspect of this proposal is our focus at the cellular level, and we are uniquely positioned to carry out our multidisciplinary aims involving biosensor engineering, innovative imaging, and multiscale modelling. We anticipate that the discoveries stemming from this project will provide the detailed understanding necessary to make strategic interventions into GA dynamic patterning in crop plants for specific improvements in growth, development, and environmental responses.

Keywords: systems biology of cellular hormone patterning
Epigenome-targeted therapy for cholangiocarcinoma. (EpiTarget)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-01
End date: 2019-01-31
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

For > 70% of cholangiocarcinoma (CCA) patients, no curative treatment is available at time of diagnosis and they proceed directly to palliative chemotherapy with virtually 0% surviving at 5 years. Breaking overall cancer trends, CCA mortality rates are escalating among both sexes in the EU, exacerbating this clinical demographic of intractable patients. Recently, a deluge of deep sequencing studies have identified recurrent mutations in epigenetic enzymes in CCA, prompting a turning point in our view of the molecular architecture of this devastating malignancy. Unlike traditional mutations, epigenetic lesions or ‘epimutations’ are intrinsically reversible and, therefore, may comprise an optimal Achilles heel to target for therapeutic benefit. However, to streamline epigenome-driven therapy to the clinic, we first need to clarify molecular and cellular responses to epigenetic manipulation in different CCA models. Accordingly, I have 3 specific objectives of this proposal: i) I plan to carry out a comprehensive in vitro epi-drug screen to determine which enzymatic targets have the greatest anti-neoplastic activity; from this, ii) I will characterize the epigenomic changes that underpin such phenotypic rescue; finally, iii) I will compare the therapeutic effects of the top global-acting epi-drug versus target-specific epigenetic editing (Epi-CRISPR) of the most recurrent epimutation in vivo. Accomplishment of these objectives will improve our understanding of cholangiocarcinogenesis and also address the unmet clinical need for novel therapeutic targets in this cancer demographic with abysmal prognosis. The project will be supervised by Dr. Jesper Andersen, a world-leading expert in hepatobiliary cancer genomics, and will draw extensively on his expansive patient bio- and data-bank. Through this work, I aim to broaden my scientific expertise (including technical and transferable skills) and to establish myself as an independent researcher in translational epigenomics.

Keywords: hepatobiliary cancer,translational epigenomics,epigenetic therapy
Political Apologies across Cultures (APOLOGY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2022-02-28
Duration (months): 66.0
Total project cost (EUR): 1917713.0
EU funding (EUR): 1917713.0
Participants: 1
Project status: CLOSED

In the past decades, there has been a considerable rise in the number of apologies offered by states for injustices and human rights violations. Among transitional justice scholars, there is significant debate about how useful such apologies are. Whereas some have applauded these gestures as an important step in peacemaking processes, others have argued that they may not fit in all cultures and may even be a risky tool for peacemaking. Unfortunately, theorizing and research in the field of transitional justice is still in its infancy and has not systematically addressed questions of cross-cultural variability yet. So, at present, we do not know whether political apologies are a universally viable way to restore justice and harmony. My project addresses this challenge. Using an innovative, interdisciplinary, and multi-method approach with in-depth interviews, (experimental) surveys, and content analyses of apologies, I analyze whether there are universals in how political apologies are valued, expressed, and interpreted or whether this varies as a function of cross-cultural differences in key values (collectivism and individualism) and norms (face and honor). Based on these findings, I build a theoretical framework that will fundamentally advance our understanding of the potential value and role of apologies in transitional justice processes. This project breaks new ground because it is the first to take the difficult step to collect cross-cultural data to examine whether key assumptions regarding political apologies hold across cultures. It is also the first in this area to use a multi-method approach, which makes it possible to take into account the complex reality of political apologies. Combining insights from transitional justice, cross-cultural psychology and anthropology, this project places theorizing on transitional justice on a much firmer footing and paves the way to more cross-culturally valid models to restore justice and promote reconciliation.

Keywords: political apologies,cross cultural,transitional justice
Targeting the Endocannabinoid System within Islets of Langerhans to Protect against Immune Destruction. (DIRECtA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-03
End date: 2020-01-02
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Europe has the highest prevalence per capita of children with type 1 diabetes (T1D), an autoimmune disease with no cure that results in progressive destruction, and finally an absolute loss, of insulin-producing beta (β) cells in islets of Langerhans in the pancreas. This means that patients require exogenous insulin administration for life. Additionally, prolonged uncontrolled blood glucose levels increase the risk of cardiovascular diseases, peripheral neuropathy, renal failure and numerous infections. The endocannabinoid receptors (ECRs) CB1, CB2 and GPR55 are regulators of metabolism and immune action and are also present on β cells. Cannabidiol, a CB1 antagonist, reduced the incidence of T1D in mice by reducing insulitis, thereby preserving β cell mass. Additionally, blockade of CB1 alters insulin secretion, increasing proliferation and autophagy in β cells. Importantly, β cell-specific CB1 knockout mice have no T-cell infiltration in islets when their pancreas is challenged. Furthermore, activation of GPR55 and CB2 are reported to be beneficial in protecting from inflammation. In this project we intend to study the interaction of the ECRs and their potential synergy for protecting β cells from insulitis. For this purpose, we will generate a non-obese diabetic (spontaneously develops autoimmune insulitis) β cell-specific CB1 knockout mouse, and use pharmacological approaches to enhance GPR55 and CB2 signalling to determine if the diabetic condition can be prevented/ameliorated. We will assess β cell damage together with mitochondrial function, autophagy, and inflammatory responses in our mouse model and after pharmacological manipulation. Thus, this project proposes a new strategy, not focusing on the immune system but on the role that β cells themselves play in modulating their own reactivity, for the development of new therapies for preventing and/or treating T1D.

Keywords: cannabinoid,insulin,beta cell,diabetes,mouse