Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Precise Genome Editing to Correct Cardiomyopathies in Human Cardiac Organoids (Edit-hCOs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 2
Project status: CLOSED

Inherited cardiomyopathies are a major cause of sudden cardiac death and are caused by mutations in genes encoding sarcomeric proteins. With an incidence of 3 per 1,000 adults within the European population, inherited cardiomyopathies present a substantial burden to the healthcare services of all European nations. Although a few medications can slow the progression of the disease, today there is no cure for cardiomyopathies. The CRISPR-Cas9 precision genome editing technologies, base and prime editing, can permanently edit point mutations of genes, making them ideal tools to treat cardiomyopathies. To demonstrate the efficacies and therapeutic benefits of these editors in correcting cardiomyopathy-causing mutations, it is necessary to develop robust in vitro models of mature human cardiomyocytes that recapitulate the cellular complexity of the human heart. In the Edit-hCOs project, I will generate and characterize human cardiac organoids (hCOs) harboring clinically relevant cardiomyopathy-causing mutations in the FLNC gene, which encodes for the sarcomeric protein filamin C. hCOs will be generated as three-dimensional scaffold-free cardiac microtissues using tri-cellular combinations of human induced pluripotent stem cell -derived cardiomyocytes, cardiac fibroblasts, and cardiac endothelial cells. Then, I will deploy base and prime editors to fix common FLNC gene mutations in the hCOs, and I will characterize their molecular and functional improvements following correction. In addition, I will generate humanized mouse models harboring the same mutations as patients for future studies on delivery, therapeutic safety, and efficacy of the genome editing components in vivo. Completion of the Edit-hCOs project will allow me to establish a completely innovative and ambitious research line focused on the permanent treatment of cardiomyopathies. This will establish a crucial and important pre-clinical step towards therapeutic genome editing of cardiovascular diseases.

Keywords: genome editing,cardiac organoids,crispr cas9,filamin c,cardiomyopathy,base editing
The future of longevity: A theoretical framework to inform mortality forecasting (LONGFOR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1499980.0
EU funding (EUR): 1499980.0
Participants: 1
Project status: SIGNED

Current mortality forecasting methods have been shown to systematically underpredict future longevity, and their methodological frameworks are based on time series extrapolation rather than theory or structural models. Given our extensive knowledge of the factors that have shaped mortality trends, a crucial question is whether considering additional traits of the populations analysed can improve prediction accuracy compared to the state of the art. The goal of LONGFOR is to develop innovative models of past and future mortality for several populations that are informed by the theoretical framework of the health transition theory. To achieve this, LONGFOR will focus on three primary research objectives: (A) to determine whether the mortality transitions of European populations stratified by sex since the 1950s have shared common patterns in terms of their mortality determinants, (B) to develop a novel theory-driven model to describe and forecast age-specific mortality by sex of multiple populations based on their mortality determinants, and (C) to extend this multi-population model to cause-specific mortality forecasting by age and sex. LONGFOR will achieve these objectives by integrating advanced statistical methods with publicly available data on mortality, fertility, population, causes of death, socio-economic, behavioural and environmental indicators. This ambitious but feasible project has the potential to make ground-breaking contributions to both mortality theory and the practice of mortality forecasting. Specifically, LONGFOR findings will have significant societal and scientific impacts by: (i) providing empirical evidence on current mortality theories, (ii) offering new insights for theoretical and modelling advancements, (iii) contributing innovative methods to forecast mortality, and (iv) improving current forecasts of both all-cause and cause-specific mortality.

Keywords: mortality forecasting mortality theory
Edged Crystalline Cohomology (ECrys)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: TERMINATED

This proposed project aims at opening new horizons in Grothendieck and Berthelot's theories of crystalline and rigid cohomology. These are p-adic cohomology theories that are used to study algebraic varieties in positive characteristic. In the last years, the subject has seen an incredible development. Recent important achievements have been, for example, Kedlaya's new proof of the Riemann Hypothesis in positive characteristic and Abe's construction of a p-adic Langlands correspondence for overconvergent F-isocrystals. On the other hand, there are still some fundamental open questions. The main weakness of the theory of rigid cohomology is the difficulty of performing classical geometric operations. For example, it is not known whether the direct image functors have all the desirable propreties (Berthelot's conjecture). This is mainly due to the fact that the definitions rely on differential forms, which need smoothness assumptions to be defined. The Applicant D'Addezio wants to use the edged crystalline site, a new site that he has recently constructed, to solve this issue. In particular, he wants to show that the edged crystalline site gives an alternative new definition of rigid cohomology and overconvergent isocrystals and then use this to prove Berthelot's conjecture. For this second step, he will exploit the fact that the definition of the edged crystalline site is completely algebraic. Other applications that will be developped include the construction of an integral structure for rigid cohomology and the construction of the category of F-isocrystals with log-decay for smooth varieties of arbitrary dimension (extending the results of Kramer--Miller).

Keywords: crystalline cohomology,rigid cohomology,isocrystals,positive characteristic
atomistiC approacHes for plasmOnic Photo Induced phenomeNa (CHOPIN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-04-01
End date: 2031-03-31
Duration (months): 60.0
Total project cost (EUR): 1384050.0
EU funding (EUR): 1384050.0
Participants: 1
Project status: SIGNED

Plasmonic catalysis is the field of chemistry that studies chemical reactions catalyzed by surface plasmons. By exploiting their unique properties, it offers enhanced reaction rates and selectivity. From a theoretical point of view, describing plasmonic catalysis is particularly challenging, because many mechanisms take place simultaneously. Such complexity and the limitations of current theoretical methods hinder a comprehensive understanding of the phenomenon. In fact, current models struggle to capture the interplay between reaction dynamics, nanostructure response, and plasmonic decay, often oversimplifying critical factors such as shape, size, and atomistic features of the plasmonic substrate. CHOPIN aims to bridge the current gaps in the modeling of plasmonic catalysis, by integrating state-of-the-art techniques from theoretical chemistry, condensed matter physics, and quantum electrodynamics. To this end, I will introduce novel, fully atomistic multiscale methodologies to describe the key steps of plasmonic catalysis: adsorption and activation of the reactants upon plasmon photoexcitation, reaction pathways, and desorption of products. The models will permit quantifying and rationalizing the effects of non-uniform spatial plasmonic fields, plasmonic decay, and hot carrier injections on chemical reactions catalyzed by plasmonic structures of any shape, size, and composition. The developed methodologies will be carefully validated and tested against selected pilot applications, focusing on complex nanoreactors with unique features such as highly localized electric fields demanding a fully atomistic description of the system. By demonstrating the robustness, effectiveness, and versatility of the proposed approaches in modeling plasmonic photo-induced phenomena, CHOPIN aims to provide a platform for integrating experimental results with theoretical predictions, thus fostering a deeper understanding of the underlying processes.

Keywords: multiscale,quantum classical,embedding,quantum chemistry,atomistic
Flexible and switchable MOF-based composites for gas separation (DynaCOMP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: SIGNED

Chemical separations are key processes in power plants and some industries like steel and iron manufacturing. To this end, energy-intensive thermal methods (e.g., distillation) are currently used making up the 45-55% of the overall industrial energy input. Hence, a transition from thermal to adsorbent-based gas separation is indispensable to address the EC objective to become Europe as the first climate-neutral continent by 2050. However, the low selectivity of the traditional porous materials currently used in industry (e.g., zeolites, carbons), make them unsuitable to meet this goal. Dynamic MOFs, a class of hybrid crystalline materials of recent development, show reversible framework rearrangements which may occur as a reaction to an external stimulus, make them unique for gas separation. They selectively adapt their pore structure to a specific gaseous component in a mixture, yielding exceptional selectivity, but lacking stability under industrial conditions. The project entitled “DynaCOMP: Flexible and switchable MOF-based composites for gas separation” aims to develop shaping strategies for dynamic MOFs towards their implementation in gas separations of industrial and environmental interest (e.g., CO2/CH4, CO2/N2, C2H2/C2H4), and to determine the impact on framework dynamicity after supporting. The project is pioneer in preparing microporous robust flexible-rigid composites of dynamic MOF thin layers supported on traditional materials, investigating their spatio-temporal phenomena. In addition, the activities described in this project will be my first steps as an independent, self-sufficient, interdisciplinar researcher; and the outcome of the overall fellowship will place me in the leading position on a new and exciting research field, with potential to tackle 21st century sustainability challenges. This fellowship includes a 3-month secondment at Karlsruhe Institute of technology (KIT) to prepare composites using advanced LPE techniques.

Keywords: flexible mofs,mof based composites,gas separation
Mycoproteins for sustainable fish feeds (NOMYFEEDS) (NoMy)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Norway
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-03-31
Duration (months): 9.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Norwegian Mycelium AS (NoMy) is an Oslo-based bioscience company established in 2020. Our vision is to make our systems of production circular by nature. Our mission is to use the biointelligence of a billion years of fungal evolution to develop new sustainable alternative proteins from fungi. NoMy does this at three levels. First, we work at the value chain level with large processing industries to design out "waste" from their system, by identifying high-volume, low value nutrient rich side streams of the production - ones that are costly to throw away. Thus we invest resources into waste utilisation rather than waste management, at a considerable savings. Second, NoMy develops circular processes (fermentation technology) for utilising these sidestreams. Our aim is to be circular in the utilisation of infrastructure as well. We invest in production systems that make use of existing infrastructure with our industrial sidestream partners. Third, this provides us with raw materials that are cost effective (where these side-stream producers give them to us or pay us to take them away) to co-create value as circular products. In these production facilities we make fungal-based products that have a fraction of the environmental footprint of existing products. And we can do it at scale, 24/7, regardless of weather, in industrial facilities that require no arable land. Better for people and the planet.

Keywords: aquaculture,circularity,mycelium,science
Machine learning for integrated multi-parametric enzyme and bioprocess design (ELEGANCE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark,Italy,Spain,Austria,Netherlands,Croatia,Czechia,France,Germany,Canada,Sweden,United Kingdom
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 4726338.07
EU funding (EUR): 4470727.68
Participants: 28
Project status: SIGNED

Currently, our world is facing several global challenges like climate change, water pollution, land erosion, resource depletion and unsustainable manufacturing. Biotechnology can provide many solutions to these problems. One example is the development of sustainable bioprocesses, which is at the heart of the EU’s green deal. Enzymes are nature’s catalysts at the core of such transformation since they can catalyse complex biocatalytic reactions. Biocatalysis has been slowly but gradually displacing traditional organic chemistry in several processes by virtue of its better efficacy, with the added value of being less wasteful as evidenced by the cornucopia of EPA Green Chemistry Awards conferred to enzymatic processes. Thanks to protein directed evolution (Nobel Prize 2018), enzyme function can be tailored to new-to-nature industrial conditions within bioreactors. However, there are still many challenges limiting bioprocess scalability, owing to a lack of deep understanding of enzyme function and of efficient strategies to overcome the complex multi-factorial optimisation problem of both enzymes and bioprocesses. To address this gap, also known as the valley of death (i.e., a large investment gap between fundamental and applied research), ELEGANCE will offer a unique educational program combining state-of-the-art experimental and computational approaches including data science and artificial intelligence to design better enzymes and bioprocesses faster. The main goal is to train a new generation of specialists with essential hard and soft skills for transforming biocatalysis into a data-driven discipline to accelerate bioprocess development, thereby anticipating potential challenges arising in the valley of death. ELEGANCE will focus on enzymes catalysing highly selective oxyfunctionalisation reactions, unattainable through existing chemical technology, with ecological and economic attractiveness to enable the transition to a circular bioeconomy in many industries.

Keywords: biocatalysis,enzyme engineering,molecular dynamics,chemical engineering,bioprocess design,data science,artificial intelligence,machine learning
European integration of new technologies and social-economic solutions for increasing consumer trust and engagement in seafood products (FishEUTrust)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Innovation actions
Countries involved: Slovenia,Portugal,Italy,Denmark,Romania,Belgium,Malta,Serbia,Spain,Montenegro,Croatia,United Kingdom,Germany,Norway
Call: Sea to fork transparency and consumer engagement (HORIZON-CL6-2021-FARM2FORK-01, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 5234758.46
EU funding (EUR): 4629816.25
Participants: 22
Project status: SIGNED

FishEUTrust represents a consortium of twenty-two organizations from fourteen countries, pooling their expertise to defragment the current food system to ensure sustainability and deliver solutions for a transparent and traceable seafood supply chain necessary to promote high-end, pan-European farmed seafood. The innovation at the heart of FishEUTrust is integrating different actors into a digital platform that links technology providers, supply chain stakeholders, regulatory/policymakers and consumers. FishEUTrust will establish five Co-creation Living Labs (CLLs) in diverse environments: the Mediterranean Basin, the North Sea and the Atlantic Sea. These CLLs will enable user involvement in innovation and development processes and act as demonstrators for the consortium to test and validate digital and non-digital supply chain solutions. Examples include creating sustainable business models, exploiting IPR strategies for aquaculture, e.g., protecting cultural and culinary heritage, short food supply chains, exploiting underused fish species, and innovative engaging activities to stimulate/nudge behavioural change. It will also develop tools for maximizing trust by guaranteeing the quality, safety, and traceability of seafood products based on smart control systems (sensors), a suite of tools integrating metagenomics, genetic biomarkers, isotopic techniques, and digital technologies (labelling, Product Passport/Blockchain). These tools will be integrated into a single cutting-edge digital FishEUTrust platform that will apply the latest in artificial intelligence, data science and human-computer interactions. Finally, an integrated impact assessment and life cycle analysis will be performed to quantify the environmental footprint, health sustainability, and socio-economic benefits of FishEUTrust solutions. FishEUTrust will be supported by a comprehensive scientific, public, policymaker and industrial dissemination plan to communicate results to a broad audience.

Keywords: aquaculture,seafood,clls,integration,transparency,traceability,innovation,consumer engagment,analytical methods,sensors,exploitation,business,impact,platform,digital,data,ai,nudging
Crimean-Congo Haemorrhagic Fever Vaccine and Immunotherapy (CCHFVACIM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Sweden,Belgium,Bulgaria,Cambodia,United States,United Kingdom,France,Germany,Türkiye,Korea, Republic of
Call: Pandemic preparedness and response: Immunogenicity of viral proteins of viruses with epidemic and pandemic potential (HORIZON-HLTH-2023-DISEASE-03, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 7755341.25
EU funding (EUR): 7755341.25
Participants: 15
Project status: SIGNED

The CCHFVACIM project is an ambitious collaborative effort aimed at developing both prophylactic and therapeutic effective countermeasures against Crimean Congo Haemorrhagic Fever Virus (CCHFV), one of the most threatening vector-borne pathogens, widely distributed, including in the European continent. Deep structural biology studies on viral glycoproteins and investigation of the immunogenicity of the viral antigens will be combined with optimisation of an mRNA vaccine candidate against the virus and characterisation of the resulting protective immunity, as well as with the development of immunotherapeutic monoclonal antibodies (mAbs) based on CCHFV’s antigenic targets. To achieve the overarching goals, the CCHFVACIM project will build on the success of previous projects such as CCHFever (FP7), CCHFVaccine (H2020) and go the extra mile by initiating a unique One-Health platform strategy to address different aspects of this severe public health threat. On one hand, the project will use several advanced animal models (mice, sheep, and non-human primate) to assess and compare the efficacy of mRNA vaccine candidates, mAbs and therapeutic mRNA; on the other hand, it will establish a biobank from CCHF patients to build up a pipeline for the production of mAbs against CCHFV from their B cells. Importantly, the project will also contribute to capacity building of European infrastructures, with the establishment of a platform on mRNA-based vaccine at one of the partner institutions. Ultimately, CCHFVACIM will permit to develop a road map to bring the most efficacious vaccine candidates and immunotherapy tools to clinical trial Phase I in humans. The project results will be widely disseminated among the scientific community, public health authorities, non-governmental organisations, outbreak management teams, and hospitals, with the final scope of both contributing to contain the burden of CCHF disease and increasing preparedness to new outbreaks.

Keywords: viral antigens immunogenicity immunotherapy monoclonal antibodies mabs mrna sheep non human primates bunyavirale zoonosis climate change tick borne viruses preparedness one health