Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development (LinPro)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Austria
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-12-01
End date: 2022-11-30
Duration (months): 60.0
Total project cost (EUR): 1996030.0
EU funding (EUR): 1996030.0
Participants: 1
Project status: CLOSED

The cerebral cortex consists of an extraordinary number and great diversity of neurons. Yet, how the cortical entity, with all its functional neuronal circuits, arises from the neural stem cells (NSCs) in the developing neuroepithelium is a major unsolved question in Neuroscience. Radial glia progenitors (RGPs) are responsible for producing nearly all neocortical neurons and a certain fraction of cortical glia including astrocytes. Our recent efforts provide evidence for a high degree of non-stochasticity and thus deterministic nature of RGP behavior in the mammalian neocortex. However, the cellular and molecular mechanisms controlling RGP lineage progression through proliferation, neurogenesis and especially gliogenesis are unknown. In a pursuit to obtain definitive insights into these fundamental questions we assess RGP lineage progression at the unprecedented single cell resolution, using the unique genetic MADM (Mosaic Analysis with Double Markers) technology. MADM offers an unparalleled approach to visualize and concomitantly manipulate sparse clones and small subsets of genetically defined neurons. Within the scope of this project we will use multidisciplinary experimental approaches to establish a research program with the following major objectives: We will 1) Functionally dissect the relative contribution of cell-autonomous intrinsic signaling and cell-non-autonomous effects in RGP lineage progression; 2) Define the principles of lineage progression in human RGPs in situ using MADM technology in cerebral organoid system; 3) Decipher the logic of glia lineage progression in the neocortex. The ultimate goal of the proposed research is to establish a definitive quantitative framework and mechanistic model of lineage progression in cortical NSCs. As such, the proposed research shall precipitate into extensive conceptual progress regarding the fundamental cellular and molecular principles of cerebral cortex development.

Keywords: cerebral cortex development,neural stem cells,lineage,single cell analysis,neurogenesis,gliogenesis,mosaic analysis with double markers madm,radial glia progenitors rgps
Wall insulation novel nanomaterials efficient systems (Wall-ACE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Germany,Italy,Germany,Italy,Germany,Switzerland,Switzerland,France,France,France,France,United Kingdom
Call: Highly efficient insulation materials with improved properties (H2020-EEB-2016, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 6254915.0
EU funding (EUR): 4289785.0
Participants: 14
Project status: CLOSED

Wall-ACE will develop a consistent package of new advanced sustainable insulation products and systems. The HONEST (High performance Optimized Nanomaterial Energy efficient SysTem) package is a “modular toolbox system” providing a set of complementary solutions that will address most of the complex challenges raised by thermal renovation as well as new construction. The HONEST package includes: insulating thermal coating-finishing with low emissivity, internal high performance insulating plaster, insulating interior patching filler, external high performance insulating render, and insulation clay bricks. These products/systems will provide top insulation performance as well as improved comfort, indoor air quality, fire safety, durability and sustainability. These highly efficient products are achieved through the synergy between the different members of the consortium through combining the high performance, sustainable, and advanced nanotechnology of the silica aerogel, with existing, already approved, efficient products. The aerogel materials structure properties and cost will be optimised. The process of the five high efficient mineral insulation systems will be scaled-up to test replicability, processability and reach industrial scale. Then, these five systems will be fully characterised including an LCA assessment, along with certification and standardization activities. In addition, the project sets a major focus on the “go to market” validation of the five products. Business planning and a field market test will be carried out, along with performance assessments on real buildings, and training and communication tools design, in order to maximize use potentials and foster a wide replication throughout Europe The products from the Wall-ACE project are key enablers to energy and CO2 emissions savings at European level. They will strengthen the industrial leadership and competitiveness of Europe in the construction sector on a global level.

Keywords: high performance insulation materials,mineral insulation toolbox,voc reduction,co2 reduction,life cycle analysis,cost effective insulation,go to market,industry excellence
Assistant Buildings’ addition to Retrofit, Adopt, Cure And Develop the Actual Buildings up to zeRo energy, Activating a market for deep renovation (ABRACADABRA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Spain,Spain,Italy,Germany,Italy,Belgium,Greece,Romania,Bulgaria,Norway,Latvia,Netherlands,United Kingdom
Call: Increasing energy performance of existing buildings through process and organisation innovations and creating a market for deep renovation (H2020-EE-2015-3-MarketUptake, 2015)
Start date: 2016-03-01
End date: 2019-02-28
Duration (months): 36.0
Total project cost (EUR): 1993168.75
EU funding (EUR): 1993168.75
Participants: 18
Project status: CLOSED

ABRACADABRA is based on the prior assumption that non-energy-related benefits play a key role in the deep renovation of existing buildings. In particular, ABRA actions will focus on the creation of a substantial increase of the real estate value of the existing buildings through a significant energy and architectural transformation. The central goals of the proposal consist of an important reduction of the pay back time of the interventions, a strengthening of the key investors’ confidence, increasing quality and attractiveness of the existing buildings’ stock and, finally, reaching a concrete market acceleration towards the Nearly Zero Energy Buildings target. The actual investment gap in the deep renovation sector is due to the fact that high investments are required up-front and they are generally characterised by an excessively high degree of risk and long payback times. It is therefore necessary to develop harmonized, concerted and innovative actions to unlock the needed public and private funds, fill the energy efficiency investment gap and ultimately contribute to re-launch the construction market and create new jobs. Therefore, ABRA aims at demonstrating to the key stakeholders and financial investors the attractiveness of a new renovation strategy based on AdoRe, intended as one (or a set of) Assistant Building unit(s) - like aside or façade addictions, rooftop extensions or even an entire new building construction - that adopt the existing buildings (the Assisted Buildings). The creation of these new Assistant Buildings’ Additions integrated with Renewable Energy Sources aims at reducing the initial investment allocated for the deep renovation of the existing building creating an up-grading synergy between old and new. The ABRA strategy results in the implementation of a punctual densification policy that has been proven capable of fostering the investments in deep renovation of the existing built environment throughout Europe

Keywords: nearly zero energy buildings,decision making tools,existing housing stock,deep energy,retrofitting,volumetrics addictions,assistant building
“Chromatin Re-organization during Shade Avoidance” (CRoSh)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Plants are sessile photosynthetic organisms, which adapt their growth and development according to their light environment. The reduction in red/far-red ratio (low R/FR), caused by absorption of red light and reflection of far-red radiation by canopy leaves, signals the proximity of neighboring plants and triggers the shade avoidance syndrome (SAS). The SAS consists in large changes in plant body form, in particular rapid elongation of selected organs providing enhanced access to sunlight. Shade-induced elongation is triggered by a rapid and transient burst in the production of the phyto-hormone auxin (IAA). However, elongation growth persists way beyond the initial increase in IAA levels and it is currently not understood how this initial signal leads to long-term growth. This project aims to identify epigenetic reprogramming events caused by reduction in R/FR and the pulse of IAA production, to allow a rapid and persistent growth response in Arabidopsis thaliana. The chromatin state of shade-grown seedlings will be analyzed by combining two novel approaches: INTACT nuclei purification and ATAC-sequencing providing information about chromatin accessibility. This data will be integrated with genome-wide expression and transcription factor binding sites enabling us to relate transcription factor binding, chromatin state and gene expression. The relevance of shade-induced changes in chromatin modification will be tested functionally by mutational analyses. This project will provide important information about the regulation of gene expression by changes in the environment and how these are mediated by hormonal cues and light-regulated chromatin organization. More broadly, understanding the response to shade has an agricultural relevance. Crops grown at high density display the SAS leading to the reallocation of resources towards fast growing stems and causing a reduction in biomass of storage organs that are important for agricultural yield.

Keywords: arabidopsis thaliana,shade avoidance response,chromatin organization,gene expression,light,signaling,atac sequencing,histone modification
Multi-layered Security technologies to ensure hyper connected smart cities with Blockchain, BigData, Cloud and IoT (M-Sec)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Greece,France,United Kingdom
Call: Advanced technologies (Security/Cloud/IoT/BigData) for a hyper-connected society in the context of Smart City (H2020-EUJ-2018, 2018)
Start date: 2018-07-01
End date: 2021-09-30
Duration (months): 39.0
Total project cost (EUR): 1499157.5
EU funding (EUR): 1499157.5
Participants: 6
Project status: CLOSED

IoT systems today tend to be built around the concept of IoT/cloud convergence, integrating heterogeneous data streams within cloud infrastructures, and thus benefiting from the scalability, performance and capacity of the cloud. This approach is very efficient for some IoT applications such as big data processing problems. However, these architectures promote a centralized data collection and processing approach, which introduces several limitations in terms of supported applications and business models that they enable. The main goal of M-Sec project is to empower IoT stakeholders to develop, deploy and operate novel IoT applications based on a scalable highly decentralized paradigm, which facilitates incentivized peer-to-peer interactions between objects and people. The project will explore semantically interoperable interactions between people/objects according to a given social context, beyond their simple peer-to-peer information exchange and internetworking. Overall, the M-Sec paradigm will enable the introduction and implementation of specific classes of applications and services that are not efficiently supported by state-of-the-art architectures. The M-Sec project will deliver a set of concrete and added value main results: 1. M-Sec distributed, self-organized, robust and trusted IoT infrastructure that empowers IoT stakeholders to develop, deploy and operate novel multipurpose IoT applications for smart cities on top of smart objects. 2. An open IoT market of applications, data and services that provides the framework upon which objects and people can exchange value and defines the motivation incentives for humans and smart objects to interact. 3. A sustainable ecosystem of stakeholders, roles, tools and infrastructures upon which new entrants and other players can build and experiment with the future application services. 4. A parameterized model on how to replicate the M-Sec approach further and guarantee its return of investment and benefits.

Keywords: security,cloud,smart cities,blockchain
Electron- and Ion Transfer at the Interface: a Hyphenated Dynamic Multi-Frequency Approach (ElIonT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-05-01
End date: 2023-10-31
Duration (months): 66.0
Total project cost (EUR): 1943600.0
EU funding (EUR): 1943600.0
Participants: 1
Project status: SIGNED

It is undisputed that electrochemistry has a central role in our contemporary society. This is demonstrated by its profound involvement in many aspects of everyday life: from powering portable electronic devices to personal electro-mobility, passing through recycling, waste water treatment, clean energy production, water desalination, personal care, and others. It appears that we have reached the limits of the technological development and no further revolutionary progresses can be achieved without a deeper understanding of the electron- and ion-transfer process at the interface. The objective of this proposal is to achieve a phenomenological modeling of the electron- and ion-transfer processes, by extending the Marcus-Hush theory of the electron transfer to a general kinetic equation based on experimental data. The extended kinetic equation should include and clarify the role of the excess free Gibbs energy on the kinetics of electron- and ion-transfer, as well as the role of the double layer charge (Frumkin effect). A unified theory of charge transfer and transport will be proposed in the frame of the phenomenological theory of transport and of classic and extended irreversible thermodynamics. Since the investigated phenomena are complex and inter-linked, the investigation techniques must seize snapshots of the system during its evolution; this will be done by hyphenating the electrochemical techniques with quartz crystal microbalance, able to measure in real time nanogram mass changes. In order to cover the time-scales necessary to develop the phenomenological theory, we will measure dynamic impedance and differential immitance spectra with a dynamic multi-frequency approach. This is based on perturbing the system with a multi-sine signal and extracting the linear and non-linear current response and mass change. The evaluation of the phenomenological parameters will rely on novel analysis algorithms and on precise modeling of the interface.
Single cell correlates of memory, motivation and individuality (SCCMMI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 2499055.0
EU funding (EUR): 2499055.0
Participants: 1
Project status: SIGNED

Directed behavior emerges from neural integration of sensory stimuli, memory of prior experience and internal states. We seek an understanding of these conserved neural mechanisms using genetically-encoded tools and the relatively small brain of the fruit fly Drosophila. By temporally controlling neural function memories can be implanted and internal states altered so that most flies behave according to our direction. Our recent studies have revealed a role for distinct subsets of dopaminergic neurons that innervate a brain region called the mushroom bodies in reward learning, memory re-evaluation and the control of motivated behavior. Although it is recognised that new gene expression is required to form persistent memories, and molecules are the targets of all therapeutic drugs in medicine, the relevant cellular sites of action often remain obscure. Knowing where memories are located in the fly brain therefore makes it possible to gain molecular level insight, with a unique perspective of being embedded within a relevant cell-specific context, of how a brain operates to alter behavior in response to rewards and internal state. Until recently, most studies of gene expression in the brain have pooled messenger RNAs purified from the entire brain, dissected regions, or small populations of fluorescently labeled material. Cell-specific expression and responses are therefore obscured by averaging signals from, often heterogeneous, collections of cells and cell-types. We will use cutting-edge Drop-seq, which permits simultaneous collection of transcriptomes from thousands of individually identified cells by first capturing each cell with a unique oligonucleotide-coated bead in a nanolitre volume reaction droplet. Our experiments will therefore provide an unprecedented individual celllevel view of transcriptional responses to memory formation and maintenance and are likely to be of broad importance and interest, given the evident conservation of gene function.
ID Ward: blockchain-based universal ID for privacy-preserving personalisation (ID Ward)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In an overcrowded digital space, personal data is key to match individual consumers with the information, products and services they want. However, the data market suffers from extreme consolidation and concentration. On one side, a handful of social platforms and search engines monopolise personal data to provide highly personalised products, services and content. On the other side, most content and service providers have so little data that they waste billions in mistargeted marketing, uncompetitive products, and slow innovation cycles. In this scramble, consumers have little or no control over their personal information and struggle to protect their privacy: their data (what they read, watch and buy online, where they live, the places they visit and the things they care about) is often collected, stored and transacted without their knowledge and consent. They experience content overload and look for original and relevant content from trusted sources. ID Ward solves these problems by making personal data an asset owned and shared directly by the consumer, who can use it to receive personalised content on publishers’ apps and websites. ID Ward works as a universal profile that aggregates data from a network of websites. Its entry point is a simple login that is used to identify the consumer and tracks activities across a network of apps and websites. The data generated by the consumer is made private using end-to-end encryption (E2EE) and used to train AI for personalisation. This reduces content overload and eliminates the need to create multiple profiles and repeatedly accept cookies, while a simple interface gives the consumer control over who can use their data for personalisation. For the companies, privacy-preserving personalisation increases traffic, improves marketing and drives ad revenue. Three large European media companies have agreed to pilot the technology and pay for the development of a prototype.

Keywords: machine learning,saas,privacy,gdpr,blockchain,ai as a service,encryption