Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Characterisation Of A Green Microenvironment And To Study Its Impact Upon Health and Well-Being in The Elderly As A Way Forward For Health Tourism. (CHARMED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Germany,Italy,Germany,Germany,Germany,Poland,Slovakia,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Denmark
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-01-01
End date: 2021-12-31
Duration (months): 60.0
Total project cost (EUR): 2430000.0
EU funding (EUR): 2430000.0
Participants: 21
Project status: CLOSED

Our society in Europe is still under prepared for the demographic changing situation of an ageing population which began several decades ago. This is visible in the age structure of the population and is reflected by the fact that the population aged 65 years and over is increasing in every European country. The growth in the elderly population may be explained by increased longevity, but at the same time, we also see an increase in debilitating conditions. However, it is also clear that the elderly are afflicted by challenging health conditions as a direct consequence of being elderly which impact their quality of life (QOL), e.g. living alone, depression, recovery from illness, immobility. This is what we would like to address. Living longer should be a privilege but there has been a collective failure to address social implications and QOL issues, where social care and the way it is funded are already in crisis. Our aim in this project is to couple the need for new societal approaches in addressing this changing demographic with improving the economy of green microenvironment sites, where health tourism and creating new jobs in this sector would in turn fund and provide benefits with respect to the well-being of the elderly. The ultimate outcome, through this pan-European academic and industrial project, will be: a) to derive cross-disciplinary and inter-sectorial knowledge of how to improve physical and mental well-being in the elderly, b) to characterise the environmental geology of Nemi and to correlate the identified features with improvements in health, well-being and recovery, c) to train a new generation of specialists in the sector of recreation and health for the tourism industry, d) the training of specialists in social and therapeutic horticulture (STH) as a way to improve physical and mental health, e) to create a model for health tourism, and f) to produce a business plan with an economic impact analysis.

Keywords: aging,health tourism,micro environment,well being
New Technology for Efficient Electrochemical Production of Synthetic Natural Gas (ElectroGas)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Portugal
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Electric grid storage continues to pose a major technical and economic pain. While the last decade has seen disruptive improvements in battery technology, even with current leading-edge solutions, large-scale applications of batteries are not economically feasible in many scenarios. This incapacity to consume large amounts of excess electricity has been one of the biggest obstacles to high penetration of renewable energy systems, such as wind power. Our CEO, José Campos Rodrigues, Electrical and Nuclear Engineer, has invented, patented and demonstrated a new technology for efficient electrochemical production of synthetic natural gas (SNG). This is considered a great energy storage due to rising prices for natural gas and the dependency from imports, and as energy carrier offers the advantages to be easily stored, transported and back-converted into energy. The European Patented Electrogas is a system that can be scaled from 1kW up to 1MW of power and will generate SNG using available non-dispatchable electricity. Conventional techniques to produce SNG require high temperatures and pressures. The capacity of Electrogas to produce synthetic gas at low temperature and pressure is revolutionary for its technical and economic feasibility. Our consolidated market segments will exceed 5 billion € in 2020 (2 digits annual growth rate), including Synthetic Fuels, the Electricity storage market, grid management systems, Islands and other isolated systems and micro-grids. Our current team of 4 members, including our Head of Sales, José Galvão Lucas, with 30 years’ experience in the liquid fuels market in Portugal and Spain, raised 500.000€ for the proof-of-concept of Electrogas (currently on our 3rd prototype, with 1kW, at TRL 6), of which 350.000€ were a research grant from the Portuguese government. Electrogas solves two of Europe’s problems: it enables higher penetration of renewable energy and locally produces SNG, increasing energy security and reducing imports.

Keywords: synthetic natural gas,grid balance,renewable energy,energy storage,low temperature and pressure production of sng
Selective Inhibition of NOTCH by novel γ-Secretase Inhibitors in Tumours (INGSIGHT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Cancer remains one of the deadliest diseases and most deaths are due to treatment failure and metastasis. Tumor resistance and patient outcome are strongly associated with tumor heterogeneity, which is promoted by the self-renewing and multipotent cancer stem cells (CSC) and by limitations in oxygen availability generating hypoxic areas within the tumor microenvironment. The NOTCH signaling pathway is one CSC pathways frequently deregulated in human cancers but also essential in many normal tissues. Given the widespread involvement in human cancers, many attempts have been made to target NOTCH (e.g. γ-secretase inhibitors, GSIs) and the hypoxic regions in the tumor (e.g. hypoxia-activated prodrugs, HAPs) in patients. However, to date, GSIs and HAPs have not been successful in clinical studies due to limited anti-tumor responses and dose-limiting side-effects in healthy tissues. As part of the ERC project DIRECT, I have leveraged our newfound knowledge on NOTCH signaling and hypoxia in tumors to develop two classes of novel NOTCH /g-secretase inhibitors (GSI) that enable tumor cell-specific inactivation of the NOTCH pathway (PSEN2-inhibitor) or by generating a dual-specificity NOTCH-inhibitor that is only released and active in hypoxic tumor regions (HyGSI) without affecting normal tissues. This ERC PoC INGSIGHT will assess the technical and commercial feasibility of these two novel inhibitors of the NOTCH pathway with the potential to radically improve cancer therapy outcomes. We will demonstrate the maximum tolerated dose in normal tissues and the therapeutic effects using five different tumor models. We will solidify our IP position and we will conduct a market, competitor, and stakeholder analysis to ensure the selection of the most optimal business strategy. As a result, we will gain technical and commercial Proof-of-Concept to determine the best route towards the commercialization of the PSEN2 inhibitor and/or HyGSI dual-specificity inhibitor.

Keywords: notch,cancer therapy,treatment toxicity,hypoxia,tumour microenvironment,secretase,dual targeting drugs
Population level interventions to improve diet and reduce social inequality (PIDS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-09-30
Duration (months): 69.0
Total project cost (EUR): 1365346.0
EU funding (EUR): 1365346.0
Participants: 1
Project status: SIGNED

Addressing social inequality in diet and health is a major public health challenge; the socially disadvantaged have the poorest diets and die the youngest. A further cause for concern is that commonly adopted public health interventions may be inadvertently worsening social inequalities in diet. We therefore need to identify interventions that benefit all, but are particularly effective in improving the diet of the disadvantaged, as this approach will reduce inequality and be the most effective way of improving overall population health. By testing a novel psychological theory, across two work packages (WPs) I will establish the type of population level interventions that worsen social inequalities in diet and identify interventions that not only improve the diet of the overall population, but also reduce inequality. WP1 will test the new hypothesis that the social patterning of executive function results in information-based nutrition interventions benefitting the socially advantaged but failing the disadvantaged, whilst structural interventions benefit all and also reduce social inequalities in diet. In WP1 I will use newly developed immersive digital reality methods to study dietary choice and laboratory feeding paradigms to examine dietary consumption in the socially advantaged vs. disadvantaged, before conducting the first ever large scale randomized control trial to identify how the real-world implementation of information vs. structural interventions affect social inequalities in diet. WP2 will exploit the knowledge generated in WP1 in order to develop a state of the art epidemiological model to simulate how the implementation of different information vs. structural nutrition policy interventions would affect population level health and health inequalities in Europe. By using inter-disciplinary methods this project will identify nutrition intervention approaches that can be used to improve population health and reduce social inequality.

Keywords: obesity,diet,eating behaviour
Co-designed Welfare Monitoring Platform for Pig and Dairy Cattle (ClearFarm)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Innovation actions
Countries involved: Spain,Spain,Italy,Spain,Israel,Finland,Finland,Finland,Finland,Netherlands,Netherlands,Netherlands,Denmark,Denmark
Call: Improving animal welfare (H2020-SFS-2019-1, 2019)
Start date: 2019-10-01
End date: 2024-03-31
Duration (months): 54.0
Total project cost (EUR): 6581670.64
EU funding (EUR): 5899105.63
Participants: 19
Project status: SIGNED

Animal welfare has become a fundamental aspect of livestock production. Current animal welfare assessment tools usually rely on momentary recordings and on awkward integration of various indicators with different units. Besides, existing tools to assess farm animal welfare are time consuming and costly. Precision livestock farming (PLF)-technology allows to monitor and optimise farming processes. PLF systems generate large volumes of on-farm data that can be used to monitor welfare in pigs and dairy cattle. ClearFarm proposes to use PLF technology and integration of animal-based data, based on a blockchain approach, to enable improved animal welfare across the entire production chain. This will contribute to improved sustainable pig and dairy cattle production, the two livestock production systems with the highest shares in Europe. ClearFarm aims to co-design, develop and validate a software platform powered by an algorithm integrating PLF data to provide animal welfare information, as well as other environmental and economic sustainability information that will assist (i) production chain stakeholders and (ii) consumers on decision making within the pig and dairy cattle value chains. Regulators, consumers and producers, policy makers, among other stakeholders, will get involved in the design of the new solution, seeking thus a multi-actor approach in most of the stages of the project. The software platform will be capable to inform the welfare status in a variety of production systems, considering geographical divergences within production systems in Europe. The outcome of the algorithm will feed a user-friendly platform that will be adapted to inform the different targeted audiences. ClearFarm will assist producers in optimizing production process, but also for consumers to have more insight into the background of animal products, providing thus a better understanding of animal welfare.

Keywords: pork,milk,precision livestock farming,multi actor approach,design thinking,block chain,labelling,pilots,ghg emissions
A holistic approach to improve the photosynthetic performance and productivity of C3 crops under diverse environmental conditions (PhotoBoost)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Germany,Philippines,United Kingdom,United Kingdom,United Kingdom,Portugal
Call: Boosting the efficiency of photosynthesis (RIA) (H2020-NMBP-BIO-2019-two-stage, 2019)
Start date: 2020-04-01
End date: 2025-03-31
Duration (months): 60.0
Total project cost (EUR): 4847105.0
EU funding (EUR): 4647105.0
Participants: 9
Project status: SIGNED

The PhotoBoost project addresses the widening gap between agricultural productivity and the global market demand for food/feed and bioenergy crops in an environmentally friendly manner by increasing the efficiency of photosynthetic CO2 fixation. This will be achieved by developing enhanced C3 crops that combine two or more of the following approaches: a) the optimisation of light reactions; b) the integration of an algal CCM; c) the introduction of an engineered photorespiratory bypass mechanism, improved by the knockout of the native plastid glycolate-glycerate transporter; and d) the optimisation of source-sink capacity, improved by the knockout of phloem-mobile tuberisation signal SP6A, thus enhancing the resilience of heat-sensitive cultivars to climate change. The consortium members have increased photosynthetic efficiency by up to 15% using individual approaches, but the stacking of multiple approaches in the same plant has never been attempted before. We will also explore e) the adaptation of stomatal conductance to improve the water-use efficiency, and f) the integration of an O2 scavenging mechanism as a novel strategy to boost photosynthesis. Experience from past and/or ongoing EU and B&MGF projects clearly indicates that although the individual approaches can be effective, they are insufficient to achieve the ambitious objectives of the current call. Therefore, the PhotoBoost project will generate optimised lines representing two major food crops (potato and rice) by simultaneously targeting multiple constraints limiting photosynthetic efficiency. We aim to increase photosynthetic efficiency under diverse environmental conditions by at least 20–25% in terms of photosynthesis rates and by at least 25–30% in terms of biomass yield. Our published results demonstrate that such approaches are viable and there is no a priori reason to doubt that combining multiple approaches in the same plant will achieve even higher levels of biomass yield and productivity.

Keywords: biomass,carbon metabolism,co2 concentration mechanisms,photorespiratory bypass,photosynthetic efficiency,potato,productivity,rice,source sink capacity,water use efficiency
Preservation of microorganisms by understanding the protective mechanisms of oligosaccharides (PREMIUM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Spain,Argentina,France,France,France,Portugal,Portugal,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-01-01
End date: 2023-06-30
Duration (months): 66.0
Total project cost (EUR): 634500.0
EU funding (EUR): 634500.0
Participants: 9
Project status: SIGNED

Microorganisms offer a large variety of functionalities that remains under-exploited due to the current inability to perform long term preservation at an industrial scale. PREMIUM project is a four-year multidisciplinary project involving a consortium of 5 academic partners from 5 European countries (France, Spain and Portugal) and 1 from third country (Argentina) and 3 industrial partners (France, United Kingdom and Spain). The project aims at developing new strategies to preserve lactic acid bacteria from laboratory to industrial scale. The innovative approaches of the project lay on: i) producing oligosaccharides of original composition for protecting cells; ii) developing novel preservation process based on encapsulation and evaluating the environmental impact of the whole system of production and stabilization of micro-organisms from the laboratory step iii) developing high-throughput characterization and screening tools such as vibrational spectroscopy. A multicriteria analysis approach will be developed to identify the most promising strategies for industrial eco-friendly preservation of micro-organisms. PREMIUM project involves 8 Workpackages (WP): WP1 is dedicated to project coordination and management. WP2 focuses on the production and characterization of a wide range of oligosaccharides. WP3 investigates and optimises new process technologies for preserving lactic acid bacteria. WP4 studies the mechanisms of bacteria preservation by oligosaccharides for defining the relevant composition and structure of oligosaccharides. WP5 focus on the scale up of processes, application to other cells and transfer of technologies to industry. The other WPs are dedicated to communication, networking and outreach activities (WP6), dissemination and exploitation of the results (WP7), ethics requirements (WP8).

Keywords: lactic acid bacteria,oligosaccharides,freezing,freeze drying,spray drying,encapsulation,sustainability,life cycle assessment,biophysical mechanisms,membrane,vibrational spectroscopies
Innovative Solutions in the Process Industry for next generation Resource Efficient Water management (INSPIREWater)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Germany,Spain,Spain,Spain,Germany,Germany,Switzerland,Sweden,Sweden,Sweden,Netherlands,United Kingdom
Call: Systematic approaches for resource-efficient water management systems in process industries (H2020-SPIRE-2016, 2016)
Start date: 2016-10-01
End date: 2020-03-31
Duration (months): 42.0
Total project cost (EUR): 7614000.85
EU funding (EUR): 5377879.5
Participants: 14
Project status: CLOSED

INSPIREWATER demonstrates a holistic approach for water management in the process industry using innovative technology solutions from European companies to increase water and resource efficiency in the process industry. This will put Europe as a leader on the world market for segments in industrial water treatment which will create new high skilled jobs in Europe. With extended collaboration between technology providers including innovative SME’s, world-wide active companies in the chemical and steel industries and research organizations, this project also contributes to the aims of the SPIRE SRA, the European Innovation Partnership (EIP) on 'Water' and to the aims of the Commission’s Roadmap on Resource efficiency, supporting effective implementation of European directives and policies in the water management area. INSPIREWATER addresses non-technical barriers as well as technical, as innovation needs both components and demonstrates them in the steel and chemical industry. A flexible system for water management in industries that can be integrated to existing systems is worked out and demonstrated to facilitate implementation of technical innovations. Technical innovations in the area of selected membrane technologies, strong field magnetic particle separator, and a catalyst to prevent biofouling are demonstrated, including valorisation of waste heat. This will increase process water efficiency as well as resource, water and energy savings in the process industry. The development and demonstration work is combined with a strong emphasis on exploitation and dissemination. Specific exploitation strategies are developed for the different solutions in INSPIREWATER. Dissemination targets different target groups: Stakeholders in different process industry also beyond the involved ones, e.g. Pulp and paper, but also policy makers based on the findings of the project.

Keywords: water treatment,resource efficiency,holistic approach,membrane technology,catalyst,magnetic separator,innovation management