Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Programmable Bionanomaterials with Protein-Controlled Behavior (Program-Material)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Estonia,Netherlands,United States,Japan,Australia,Argentina,Switzerland
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 1007400.0
EU funding (EUR): 1007400.0
Participants: 10
Project status: SIGNED

Program-Material is a research and innovation staff exchange network dedicated to pushing the boundaries of nanomaterials and nanotechnologies by introducing integrated protein-controlled behaviors. Our primary goal is to craft hybrid nanostructured materials featuring precise structural, functional, and spatiotemporal behaviors directly regulated by specific proteins. By incorporating synthetic biology components, these materials will demonstrate the ability to perform tailored chemical or biological functions, guided by specific proteins. This innovation holds tremendous potential for groundbreaking applications in biomedical and healthcare contexts. While traditional approaches focus on engineering nanomaterial properties to influence biological entities, Program-Material pioneers bio-based control over nanomaterial properties, emphasizing programmable influences of biomolecules—particularly proteins. Program-Material seeks to cultivate a new generation of scientists at the intersection of materials science and biotechnology. This expertise will drive innovative solutions in advanced healthcare nanomaterials, fostering unprecedented interactions with biology, particularly in precision and nanomedicine applications. To achieve these ambitious goals, we have united 9 academic partners and 1 non-academic partner in a collaborative network. This team spans European and extra-EU institutions (USA, Australia, Argentina, Switzerland, Japan) and encompasses individuals ranging from PhD candidates to experienced researchers. Our diverse composition ensures Program-Material's robust interdisciplinary and intersectoral dimension, vital for a broad and effective impact. The program places a strong emphasis on actively involving young professors, providing pivotal support for their career progression. Knowledge transfer and associated training activities are crafted to equip scientists with specific competencies in materials science, bionanotechnology, and nanomedicine.
Search for the missing unicellular relatives of animals (MISSINGRELATIVES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Spain
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 2499948.0
EU funding (EUR): 2499948.0
Participants: 1
Project status: SIGNED

How animals emerged from their unicellular ancestors remains a major evolutionary question. Work done on diverse unicellular relatives of animals demonstrated that the unicellular ancestor of animals had a larger repertoire of genes associated with multicellularity than previously thought. These include “animal-specific” genes such as protein tyrosine kinases, integrins and Brachyury. This suggests a latent genetic potential in place at the origin of animals and hints at a much more gradual transition in their emergence. However, a comparison of extant early-branching animals and their unicellular relatives still reveals an abrupt difference between protists and the body plans of extant animals. This gap could be due to intermediate lineages going extinct, or that descendants of key lineages have not been found yet. Recent DNA environmental surveys suggest the latter, revealing several novel kingdom-level lineages that branch close to animals and remain unknown. We will not make progress in understanding the origin of animals until we have explored the real diversity of animals’ closest relatives and isolated the major lineages that remain uncharacterized. Indeed, some of the answers to animal origins that we can not currently address with our taxon sampling are likely hiding in hindsight in those unsampled lineages. Notably, a targeted survey of animal relatives has not been done. I propose to do this by exploiting recent developments in long-read metabarcoding. We will screen different environments and isolate the novel lineages using fixation-free labeling methods. We will culture them and get their genomes. We will provide a complete picture of the diversity among animal relatives, which will also be relevant to ecologists. Notably, the novel lineages will allow us to address fundamental questions about the origin of animals that cannot be answered with the current taxon sampling, including the origin of embryogenesis and spatial cell differentiation.

Keywords: animals,metabarcoding,holozoans,protists,multicellularity,life cycles,ancestor reconstruction,isolation,culturing
Storytelling as Pharmakon in Premodernity and Beyond: Training the New Generation of Researchers in Health Humanities (StoryPharm)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Cyprus,Germany,Sweden,Denmark,United Kingdom,Italy
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 3876998.4
EU funding (EUR): 3876998.4
Participants: 12
Project status: SIGNED

StoryPharm will deliver an international, interdisciplinary, and intersectoral programme of doctoral training recruiting 15 fellows, who will become highly skilled cultural historians specialising in premodern intellectual and healthcare worlds (Greco-Roman, Sasanian, Byzantine, Western Medieval, and Islamic). Acquiring interdisciplinary knowledge in Classics, Medieval Studies, Narrative Medicine, Health Humanities, and Medievalism, along with transferable skills, the fellows will be able to use, develop, and deploy cutting-edge approaches to storytelling and its ethical ramifications for scientific, professional, business, healthcare, and social purposes. The consortium of StoryPharm will comprise 5 universities across Europe (UCY, UNI BA, LU, CU, & UNI SA). It will also have 7 associated partners including non-academic and non-profit institutions, businesses, and health and pharmaceutical actors. StoryPharm’s research objectives and training programme, including secondments in both academic and non-academic environments, will expose the fellows to a variety of research, training, and work settings. By integrating interdisciplinary and transdisciplinary methodologies and engaging leading experts from various fields, StoryPharm will deliver an innovative PhD programme that will go beyond the standard PhD curriculum in the Humanities. The combination of academic and hands-on training associated with exposure to diverse settings will produce a critical mass of young specialists with exceptional career prospects in academia, industry, and the healthcare sector. These specialists will be ideally positioned to (1) achieve ground-breaking research results; (2) meet current trends and needs in the job market; (3) work towards establishing a human-centred medical system; and (4) create better and more resilient societies. StoryPharm will establish the field of premodern Health Humanities and address the need for a dialogic and empathetic approach in the healthcare sector.

Keywords: textual and visual storytelling,narrative medicine,health humanities,history of medicine,cultural and social history,antiquity,middle ages,medievalism,cultural heritage
Asgard Archaea and Earth's Oxygenation: Uncovering Key Aspects of Eukaryogenesis (AsgOx)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1549766.0
EU funding (EUR): 1549766.0
Participants: 1
Project status: SIGNED

Many aspects of life's evolutionary history remain poorly understood, such as the emergence of complex eukaryotic life. The recent discovery of Asgard archaea in anoxic sediments has provided fundamental insights into this process due to their phylogenetic proximity to eukaryotes and their eukaryote-like protein repertoire. The cultivation of the first two anaerobic organisms from this group, both belonging to the Lokiarchaeia, provided support for their role in eukaryogenesis, especially with the detection of a eukaryote-like actin cytoskeleton. Despite these advances, there are still many unanswered questions, such as what was the environmental context of this process, especially considering that the Great Oxidation Event (GOE) preceded it. Some hypotheses suggest that mitochondria evolved in anoxic conditions, while others propose a link between higher cell complexity and rising oxygen levels. The Asgard archaea now considered closest to eukaryotes, namely the Heimdallarchaeia class and its subgroups Hodarchaeales and Kariarchaeaceae, are the only ones thought to be facultative aerobes, fueling this debate, though no cultured representatives exist. This proposal aims to deepen our understanding of oxygen-related processes in Asgard archaea, focusing on reactive oxygen species, and to use these organisms to better understand the ecological context of the rise of eukaryotic life. This will involve i) cultivation of the first facultative aerobic Asgard archaea, thought to be the closest to eukaryotes, ii) comparative phylogenetic analysis of Asgard archaea proteins involved in coping with oxygen, iii) biochemical characterization of these proteins using heterologous expression, iv) expression of these proteins in genetically tractable anaerobic archaea. This project will provide unique insights into the ecology and cell biology of our archaeal ancestors, leading to a transformative understanding of the environmental and evolutionary context of eukaryogenesis.

Keywords: asgard archaea,cultivation,eukaryogenesis,antioxidant proteins,comparative genomics,phylogenomics
Dynamic Modeling of Non-Pharmacological Interventions for Type 2 Diabetes (DyNPI-T2D)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: SIGNED

The prevalence of type 2 diabetes (T2D) is projected to increase by 100 million within years. However, while lifestyle changes are recommended by the WHO to counter & mitigate diabetes, comprehensive intervention experiments that consider the interplay of different lifestyle factors are lacking, as are clinical tools to evaluate such interplay. The present project will address these outstanding issues through two major undertakings: (1) A first long-term dynamic intervention experiment encompassing multiple lifestyle factors (diet, sleep & exercise) will be conducted in 200 subjects with & without T2D. The participants’ daily multimodal health data (biochemical markers, sleep, questionnaires, etc.) will be recorded, to form a high-resolution dynamic intervention database with unprecedented integrative & temporal resolution, which will be stored securely and made available for fellow scholars and the public to take advantage of. (2) The project will, for the first time, use the concept “Order Parameters” from statistical physics to represent different health states treated as distinct “ordered statuses”. Thus, a novel multimodal model will be built to characterize the temporal evolution of health variables that the modelling pinpoints as being the most predictive longitudinal parameters. The project will thus enable personalized predictions for holistic health trajectory, by analyzing the general physical laws followed by the temporal evolution of model parameters, also in relevant T2D & healthy subgroups. The two undertakings provide excellent quality control & risk assessment via six tailored work packages consisting of 32 milestones and 4 deliverables. This will provide an effective assessment tool for public health monitoring, at both the individual & policy level. More importantly, it will enable a paradigm shift from traditional group-level descriptive statistics, to precise quantitative assessment for longitudinal evaluation of key clinical health parameters.

Keywords: intervention experiment,dynamic modeling,temporal evolution,lifestyle change,type 2 diabetes
Virtual Brain Twin for personalised treatment of Psychiatric Disorders (VIRTUAL BRAIN TWIN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Belgium,France,Spain,Romania,Germany,Greece,Sweden,Netherlands,Italy
Call: Integrated, multi-scale computational models of patient patho-physiology (‘virtual twins’) for personalised disease management (HORIZON-HLTH-2023-TOOL-05, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 10000000.0
EU funding (EUR): 10000000.0
Participants: 19
Project status: SIGNED

In the EU, about 165 million people are affected each year by mental disorders, and estimates indicate that mental disorders will become the number 1 economic cost factor in medicine in 2030. Schizophrenia alone affects approximately 1% of the world's population. The clinical effectiveness of the antipsychotics on the market remains limited with 30 to 50% of schizophrenic patients showing an insufficient response to treatment. Several factors, from genetic to psychological and social, may lie behind poor treatment outcomes or side effects and varies from patient to patient. Therefore, the central aim of the VIRTUAL BRAIN TWIN project is to create an ecosystem for generating virtual brain twins for psychiatric patients, by leveraging the consortium’s detailed knowledge and expertise in neuronal microcircuit simulation, mathematical analysis, innovative AI tools, and psychiatric care and clinical studies. This ecosystem will guide clinicians to optimise medication type and dosage, and to evaluate alternative treatments, such as brain stimulation and lifestyle changes. Multiscale cause-effect simulations and virtual brain simulations based on fMRI or sMRI data from the individual patient, will bridge the gap between molecules and the patient's brain. At the centre of this ecosystem will be the Virtual Brain Twin platform, which will make use of big data, multiscale modelling, and high-performance computing (HPC) that will be secured by appropriate data safety and protection. The platform will be embedded in the European digital neuroscience research infrastructure EBRAINS and will be initially accessible to neuroscientists, clinical researchers, and mathematical modellers, and in the future, to clinicians, and patients as well. This ground-breaking project will pave the way for personalised treatment of psychiatric disorders, with the potential to significantly improve the quality of life of patients suffering from these conditions.

Keywords: ebrains,personalised treatment of psychiatric disorders,schizophrenic patients,psychosis,high performance computing,big data,multiscale modelling,cause effect structure
Spaces of Encounters and burial Practices of the Other: Liminality, Cemeteries, and funerary Rituals in early modern Italy (SEPOLCRI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-02
End date: 2027-05-01
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 1
Project status: SIGNED

SEPOLCRI seeks to provide the first connective analysis of non-Catholic funerary practices and burial spaces in Italy c. 1500-1780. The project will focus on a variety of non-Catholic subjects (Jews, Orthodox Christians, Protestants, and Muslims) from different social strata and at different stages of mobility: settled and well-established communities; semi-permanent communities such as merchants, students, and enslaved people; and transient subjects such as travellers, seasonal workers, and seafarers. The research will focus on both key trading, religious and cultural centres (Livorno, Naples, Rome, Trieste, and Venice) and on more peripherical cities which have been neglected by the scholarship but had an important presence of minority groups (Ancona, Civitavecchia, Mantua, Padua, and Pisa); information on such cities and more peripheral territories will also be acquired through the consultation of key Inquisition archives whose material is among the best preserved in Italy (Rome, Venice, Pisa, Modena, and Naples). By focusing on how the funerary practices of non-Catholic groups shaped the relationship with the dominant Catholic community, SEPOLCRI will make a transformative contribution to the scholarship on religious diversity, urban history, and Counter-Reformation studies. The project examines continuities and changes in the relationship between the dominant Catholic community and minorities after the Reformation until the advent of the Enlightenment, reflecting changing attitudes towards minority groups linked to social and religious impurity. The research puts marginalized members of society at the core of research, reshaping the understanding of premodern issues of inclusion and exclusion, tolerance and intoler-ance, negotiation and representation in the political, religious and social urban panorama.

Keywords: religious diversity,urban space,death,mobility,minorities,early modern,italy,cross cultural encounters
Nature based interventions for improving health and well-being (NATURELAB)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Resilient, inclusive, healthy and green rural, coastal and urban communities
Action type: Research and Innovation actions
Countries involved: Portugal,Germany,Greece,Peru,Netherlands,United Kingdom
Call: Developing nature-based therapy for health and well-being (HORIZON-CL6-2022-COMMUNITIES-02-two-stage, 2022)
Start date: 2023-06-01
End date: 2027-11-30
Duration (months): 54.0
Total project cost (EUR): 5839880.2
EU funding (EUR): 5839379.5
Participants: 14
Project status: SIGNED

NATURELAB will contribute to increased recognition, promotion and use of green and blue spaces as health care providers, by investigating the benefits of nature-based therapies (NBT) to promote well-being and support health prevention & rehabilitation. Around 4000 participants from 15 Experimental Sites and 4 Demonstrator Fellows located in rural, coastal, and urban areas of five European and Latin American countries (PT, EL, NL, DE, and PE) will experience the NATURELAB NBT programmes. The participants will ensure a representative sample of gender, age and socioeconomic status. The geographic locations comprise a variety of climate, nature (green and blue), ecosystems, biodiversity, cultural, policy and administrative scenarios. The health issues that will be addressed include physical (hypertension) and mental conditions (depression), among others. NATURELAB proposes an innovative approach to contribute to resilient communities, by enhancing the green and blue areas' benefits - as the resilience to climate change, the promotion of biodiversity and urban water management, and addressing as well air pollution and noise levels. The project will deliver, among others: i) NBT programmes tailored to population with different needs; ii) Portfolio of indicators to classify the health potential of nature & Guidelines to analyse the health benefits of green areas as required by natural capital accounting; iv) Guidelines for the creation and management of private and public healing gardens, horticulture/gardening spaces merging climate resilience and environment sustainability; iv) Programme Guide for funding scheme to support NBT in the health sector and v) Guidelines to promote the integration of NB care in the public health sector. Around 600 health professionals worldwide will receive the NATURELAB NBT programmes, and 8000-10000 innovative educational and training materials will be delivered. New jobs - therapists; horticulture & gardening industries -will be exploited.

Keywords: nature based solutions,nature based therapies,experimentation,mixed methods,urban healing gardens,climate change resilience,community led innovation,jobs and education