Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Targeting the purinergic system for disease-modification in epilepsy (EpiPurines)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-04-01
End date: 2025-03-31
Duration (months): 36.0
Total project cost (EUR): 257561.28
EU funding (EUR): 257561.28
Participants: 2
Project status: SIGNED

Current epilepsy therapies, based on mediating excitation or inhibition, are ineffective in 30% of patients & have no impact on disease progression, demonstrating an urgent need for new therapies. Mounting evidence showed the therapeutic potential of targeting the purinergic system during epilepsy with the disease-modifying effects observed via targeting the P2X7 receptor & Adenosine kinase (ADK) being a promise. P2X7 & ADK are increased in the brain in experimental models of epilepsy and in patient brain. Further, data showed anticonvulsive & anti-epileptogenic potential of targeting P2X7 or ADK. To advance these findings towards a clinical application, results must be replicated in animal models mimicking closer the human condition (e.g.TBI model) and effects must be tested in human cells (hiPSC). Importantly, while there is now compelling evidence demonstrating the therapeutic potential of targeting both P2X7 & ADK separately, a combined treatment, targeting both simultaneously, may lead to better seizure control & suppression of epilepsy. By using relevant animal models of epilepsy and hiPSC, EpiPurines will establish the disease-modifying potential of targeting different components of the purinergic system during epileptogenesis, thereby establishing P2X7 & ADK-targeting as potential treatment for epilepsy. To achieve this, EpiPurines brings together, for the first time, a team of experts in purinergic signaling from different research fields (Adenosine & ATP-signalling) & industrial partners. This highly interdisciplinary & intersectoral approach will contribute significantly to the understanding of purinergic signalling during seizures & epilepsy providing novel therapeutic approaches. The skills acquired during the research project, the excellent training record of the supervisors & host institutions and the outstanding resources for learning & development available at RCSI & RU will give me the tools necessary to become a highly employable neuroscientist.

Keywords: purinergic signalling,traumatic brain injury,epilepsy,p2x7 receptor,adenosine kinase,animal models,ipscs
Holistic processes for the cost-effective and sustainable management of End of Life of Aircraft Composite Structures (HELACS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Spain,Belgium,United Kingdom
Call: Large scale aircraft composite structures recycling [ECO] (H2020-CS2-CFP11-2020-01, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 1918500.0
EU funding (EUR): 1796775.0
Participants: 4
Project status: SIGNED

HELACS will be based on i) previous results of end of life aircraft management projects (such as PAMELA or AIMERE), ii) the review of recommendations and standards for aircraft disassembly and aircraft materials recycling (such as the developed for the Aircraft Fleet Recycling Association - AFRA) and iii) the experience and support of the biggest Maintenance, Repair and Overhaul (MRO) entity in Europe, Teruel Airport (PLATA), to implement a cost-competitive and energy efficient solution for dismantling and recycling Carbon Fibre Reinforced Polymer (CFRP) components. To do this, stakeholders of multiple areas of the aircraft designing, manufacturing and recycling value chain will collaborate during the project, through a Responsible Research and Innovation (RRI) approach. Thanks to this multiactor approach, HELACS will properly include the European Industry necessities when the current dismantling and recycling processes will be improved to properly manage CFRP components, now and in the future, by transferring innovative technologies and systems in two main pillars: • Flexible and Portable Robotic Platform with machine learning capabilities and dedicated tools for CFRP cutting and debonding • Recycling and valorisation technologies based on optimised pyrolysis processes for improving carbon fibre recycling yield and sizing formulation for improving carbon fibre functionalities During HELACS, these processes will be developed, validated and demonstrated in the Teruel airport facilities to improve the recyclability of CFRP components by 40%, increase workforce safety and satisfaction by 70%, allow the value retention of recycled carbon fibres by 85%, reduce the CO2 emissions by 50% and increase the profitability by 30%. Finally, the exploitation and dissemination of HELACS results will mobilise more than 30 € million and generate more than 750 new direct jobs by 2030 by transferring the new dismantling and recycling processes to the European Aeronautic value chain.

Keywords: dismantling,recyclign,robotics,pyrolysis,sizing,debonding on demand
Innovative Microturbine Technology For Delocalised, Off-Grid Electricity Generation (AirWatt)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy,Italy,Italy
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 1429803.75
EU funding (EUR): 1000862.13
Participants: 3
Project status: CLOSED

Advanced Microturbines and FAST’s AirWatt project is a Phase 1 winning project from the Horizon 2020 SME Instrument call of June 2014. The project is based on the industrialisation and commercialisation of a patented, miniaturised, integrated turbine and electrical generator, designed to be introduced into the gas supply pipelines, taking advantage of existing pressure drops and gas flow in the system to generate electricity that can be used to power apparatus for the monitoring and control of the pipeline. Our plan is to use our microturbine to power locally smart gas grid solutions, such as monitoring and control remote terminal units (RTUs). Founded in 2013 in Genoa, Italy, as a spin-off of the Italian Institute of Technology, Advanced Microturbines Srl, is a technology-driven micro-enterprise and inventor of the integrated, miniaturised turbine-generator that is the basis for AirWatt. In our mission to develop our innovative idea and bring to the market novel solutions for energy storage and supply system for off-grid applications, we encountered the company FAST SpA, a manufacturer of automation and process control systems based in Reggio Emilia, Italy. With more than 30 years of experience, FAST is one of the leaders in control and supervision systems, recognised for their state-of-the-art solutions.

Keywords: microturbine,remote terminal unit,turbine,energy harvesting,smart grid
Citizen-centred EU-EHR exchange for personalised health (Smart4Health)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Germany,Italy,Germany,Belgium,France,Netherlands,United States,Luxembourg,Portugal,Portugal
Call: Prototyping a European interoperable Electronic Health Record (EHR) exchange (H2020-SC1-DTH-2018-1, 2018)
Start date: 2019-01-01
End date: 2023-10-31
Duration (months): 58.0
Total project cost (EUR): 21781120.0
EU funding (EUR): 21781120.0
Participants: 22
Project status: SIGNED

Smart4Health will enable the citizen-centred EU EHR exchange for personalised health. This will pave the way for the full deployment of citizen-centred solutions and services in a digital single market for wellbeing and healthcare. It will provide for interoperability, complementarity and cooperativity with profiles that are currently used e.g. by Member States and regions. Smart4Health will enable the bridging between the diverse EU EHR data and citizen-generated health data. It will connect citizens to science and personalised health services. The European Commission 2017 review of the Digital Single Market lists three priorities: 1) Citizens´ secure access to electronic health records and the possibility to share it across borders, 2) Supporting data infrastructure, to advance research, disease prevention and personalised health and care 3) Facilitating feedback and interaction between patients and healthcare providers, to support prevention and citizen empowerment as well as quality and patient-centred care. Smart4Health addresses these priorities with an outstanding consortium that develops, tests and validates a platform prototype for the Smart4Health citizen-centred health record EU-EHR exchange. Smart4Health provides an easy-to-use, secure, constantly accessible and portable health data and services prototype, thus advancing citizen health and wellbeing, and digital health innovation. Smart4Health builds on the strength of the European infrastructures CEF, ELIXIR, the EIT Health, BBMRI-ERIC, the European Virtual Laboratory for Enterprise Interoperability (I-VLab), the experience and knowledge gained and generated, the EU/US collaboration in eHealth, e.g. the Icahn School of Medicine at Mount Sinai, the momentum of initiatives in the Member States, e.g. 'Medizininformatik Initiative' of the BMBF in Germany. Smart4Health enables citizens to manage and bridge their own health data throughout the EU and beyond, advancing own and societal health and wellbeing.

Keywords: occupational health,worker protection,fitness,healthy ageing,digital infrastructure,digital single market,eu us cooperation
Active organotypic models for nanoparticle toxicological screening (ActiTOX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria,Austria,Austria,Germany,Germany,Hungary,Czechia,Denmark,Portugal
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2018, 2018)
Start date: 2019-08-01
End date: 2024-07-31
Duration (months): 60.0
Total project cost (EUR): 1191400.0
EU funding (EUR): 1191400.0
Participants: 10
Project status: SIGNED

Nanoparticles and new drugs are undergoing complex toxicity evaluation prior to their use in products for customers. However, the traditional pre-clinical testing protocols are delivering significant disadvantages both from ethical (animal testing) and functional (high attrition rate in clinical testing) point of view. ActiTOX reacts to this problem by the development of a novel, pre-clinical, high content, in vitro testing platform focused on the evaluation of nanoparticles/drugs via ADME (absorption, distribution, metabolism, excretion) toxicity studies. In order to advance the current state of art the project will employ biomimetic scaffolds, drug delivery systems, human induced pluripotent stem cells (iPSCs), 3D-microfluidics and modular bioreactor technology. ActiTOX aims to increase the relevance of in vitro studies and provide a scalable approach for their use in drug development and toxicological screening. In order to achieve the project goals, a training network enabling efficient short-term secondments of ER and ESR between academia and industry will be established. The cooperation between stakeholders helps closing the gap between them and oint innovation to foster the current state of the art. ActiTOX will mediate it via networking, research, training, workshop, innovation and dissemination actions in form of short-term secondments. The project fulfils the aim of a RISE project and delivers significant social impact, increases knowledge based economy and creates long lasting cooperation strengthening the European research area.

Keywords: adme,nanoparticle toxicity,drug development,biological barriers,organotypic 3d models,biomimetic scaffolds,nanfibers,electrospinning,drug delivery,microfluidic,3d printing,bioreactors
Towards Adaptively Morphing Embedded Systems (ADMORPH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Ireland,Sweden,France,Czechia,Netherlands,Netherlands,Luxembourg,Portugal
Call: Computing technologies and engineering methods for cyber-physical systems of systems (H2020-ICT-2019-2, 2019)
Start date: 2020-01-01
End date: 2023-06-30
Duration (months): 42.0
Total project cost (EUR): 4499468.75
EU funding (EUR): 4499468.0
Participants: 11
Project status: SIGNED

Due to the increasing performance demands of mission- and safety-critical Cyber Physical Systems (of Systems) – after this referred to as CPS(oS) – these systems exhibit a rapidly growing complexity, manifested by an increasing number of (distributed) computational cores and application components connected via complex networks. However, with the growing complexity and interconnectivity of these systems, the chances of hardware failures as well as disruptions due to cyber-attacks will also quickly increase. System adaptivity, foremost in terms of dynamically remapping of application components to processing cores, represents a promising technique to fuse fault- and intrusion tolerance with the increasing performance requirements of these mission- and safety-critical CPS(oS). In the ADMORPH project, we evaluate this hypothesis using a novel, holistic approach to the specification, design, analysis and runtime deployment of adaptive, i.e., dynamically morphing, mission- and safety-critical CPS(oS) that are robust against both component failures and cyber-attacks. To this end, we will address four aspects that are instrumental for the realization of these adaptively morphing systems: (i) the formal specification of adaptive systems; (ii) adaptivity methods like strategies for maintaining safe and secure control of CPS(oS); (iii) analysis techniques for adaptive systems to, e.g., perform timing verification of adaptive systems to avoid timing violations after system reconfigurations; and (iv) run-time systems for adaptive systems that realize the actual run-time system reconfigurations to achieve fault and intrusion tolerance. The developed methodologies, methods and tools will be evaluated using three industrial use cases taken from the radar surveillance systems, autonomous operations for aircrafts, and transport management systems domains.

Keywords: cyber physical systems of systems,fault tolerance,intrusion tolerance,adaptive systems,mission and safety critical systems,run time systems,analysis of adaptive systems
Research and training network on MIniaturized Gas flow for Applications with enhanced Thermal Effects (MIGRATE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland,Italy,Germany,Greece,Bulgaria,Belgium,France,France,France
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-11-01
End date: 2019-10-31
Duration (months): 48.0
Total project cost (EUR): 3815117.07
EU funding (EUR): 3815117.07
Participants: 10
Project status: CLOSED

Depletion of natural resources combined with the extending footprint of mankind has led to a shift in importance of research and development topics. In the 1970s and 1980s process yield was primarily targeted, but emphasis is now focussed on resource efficiency as a primary objective. Routes for resource efficiency have to be identified and implemented to provide a more environmental and resource-oriented technology in near future. MIGRATE is planned as an ETN, gathering top-level research and development capabilities from academia and industry as well as direct application possibilities with the focus set on thermal aspects of gas flows in microstructured systems. Within MIGRATE, a number of ESR projects will cover different aspects of enhanced heat transfer and thermal effects in gases, spanning from modelling of heat transfer processes and devices, development and characterization of sensors and measurement systems for heat transfer in gas flows as well as thermally driven micro gas separators to micro-scale devices for enhanced and efficient heat recovery in automotive, aeronautics and energy generation. This unique combination of university research, SME and world leading industrial stakeholders will contribute in a significant way to the increase of knowledge about micro scale gas flow heat transfer problems as well as to industrial applications of highly efficient miniaturized devices. A characteristic of MIGRATE is the high degree of applicability and the intense training. About 30% of the beneficiaries are from private sector. Thus, ESR projects will be developed in both directions, fundamental academic knowledge as well as direct application in industrial environment. The training of the ESRs is set in the same way to provide a broad variety of skills, reaching from classical academic research to IPR management and all-day-business in a company, being summarized under the aspect of resource efficiency and environmental-friendly technological approaches.

Keywords: microsensors and analysis,micro manufacturing,gasflow heat transfer,electronics cooling,heat recovery,gas cleaning,thermal gas separation,gas surface contact,thermal gas movements
Gate Tuneable Superconducting Quantum Electronics. (SuperGate)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Switzerland,Hungary,Sweden,Netherlands
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-03-01
End date: 2024-08-31
Duration (months): 42.0
Total project cost (EUR): 3059348.75
EU funding (EUR): 3059348.75
Participants: 7
Project status: SIGNED

Supercomputers are playing an increasingly important role for our society by performing calculations with a variety of implications ranging from weather forecasting to genetic material sequencing to testing of drugs for new diseases. Enhancing the performance of modern supercomputers, whilst minimising their energy losses, represent two contrasting but major needs that the information technology industry will have to address in the future. The best solution proposed to date to reduce the energy costs of supercomputers without affecting their performance is based on hybrid computing architectures, where a semiconductor part based on complementary metal-oxide semiconductor (CMOS) technology and used for memory operations is combined at low temperatures with logic circuitry offering minimal energy losses thanks to the usage of superconductor (S) materials. Existing superconducting logics, which relies on rapid single flux quantum (RSFQ) technology, however, it is difficult to interface with CMOS and to scale up and it is sensitive to magnetic perturbations – which are the main reasons why hybrid platforms have not replaced CMOS systems despite their advantages. Starting from our recent discovery that the logic state in some S devices can be controlled via the field effect (FE), in this project we propose to develop a new technology for superconducting logics that can offer performance at least comparable to that of RSFQ logics whilst overcoming all its drawbacks. We will adopt a systematic approach aiming at (i) understanding of the FE in a S, (ii) determining the S materials and device geometry with optimised performance, (iii) testing the dynamic response of optimised devices, (iv) developing logic circuits based on such devices and (v) testing a logic circuit in conjunction with a CMOS electro-optical modulator. We will also establish technology transfer and pave the way for the commercialisation of our technology, which can revolutionise the world of supercomputer.

Keywords: superconducting devices,superconducting logics and computing,field effect transistors,josephson effect,device nanofabrication and testing,hybrid superconductor,semiconductor architectures
Promoting Synthetic Polyploid Engineering Commencing Technology (ProSPECT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

Polyploids, which result from Whole Genome Duplication (WGD) events, are thought to have enhanced adaptability which might explain why they are so pervasive in nature and especially in crop plants. Furthermore, polyploids exhibit multiple advantages, from an agricultural perspective, such as often having larger fruits, and being more resilient to like drought and salinity. However, polyploidy requires evolving an adapted meiosis (well documented in natural polyploids) to cope with their additional chromosome sets during meiotic segregation; otherwise, resulting aneuploidies lead to genome instability and fertility problems. Because little is known about these adaptive mechanisms, the meiotic instability displayed by artificially generated (synthetic) polyploids (which lack of an evolved meiosis) cannot be eluded and the use of these synthetic polyploids remains exceptional as a tool to generate novel crop varieties. It is expected that regulating meiotic crossovers to prevent formation of multivalent associations among more than two homologous chromosomes during meiosis would decisively improve segregation and fertility of synthetic polyploids. While compelling, this hypothesis has not been formally tested. ProSPECT aims to address the problem of genome instability in synthetic polyploids by testing the viability of two strategies to artificially induce meiotic adjustments that might improve chromosome segregation using Arabidopsis thaliana polyploid mutants as a proof of concept. To do so I will use two strategies: (a) First, I will use meiotic recombination mutants known to reduce the number of meiotic crossovers to test if this is sufficient to limit the chances for multivalent formation in A. thaliana synthetic polyploid inbreds. (b) Second, I will use polyploid hybrids carrying combinations of meiotic mutants known to restrict meiotic crossovers to (nearly) identical partners to test if this is sufficient to impede associations among more than two chromosomes.

Keywords: meiosis,polyploidy