Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
International higher education student recruitment going mobile (Unispotter)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Unispotter is the first education agent mobile end-to- end solution providing global student recruitment from one source using a human-machine approach to automate and personalize the application journey at the same time, while reducing workload and cutting costs for both students and universities. Unispotter transforms higher education admission and disrupts the education agent marketplace by delivering all of its services via an app and automated processes: university program scouting, application document preparation & delivery, and enrolling. There are over 4 million globally mobile tertiary education students, with 1.7 million students seeking placement support services worldwide and this number is set to increase. By 2024, Unispotter’s total available market is predicted to reach 3.4M students seeking guidance ( meaning a ~ €6.8b in revenue potential considering an average commission of €2000/student placed), of which Unispotter will lock 2% of the market (~€136M). Initially Unispotter plans to target prospect partner universities in Germany and Austria (home markets), and the UK, Australia, Canada & US (the world’s largest markets for international students), and then set on further EU markets. Bringing the Unispotter platform to TRL9 from TRL 6 today, and approaching commercialization by 2020, Unispotter will require funding in the range of €2.4 million which it plans to lock from private investors and validating support from SME Instrument Phase I and II. Unispotter already has the human resources to complete the commercialization plan. Christoph Trost (co-founder) and his team of 5 already grew Unispotter app downloads in Austria & Germany from 0 to 100K. Unispotter anticipates rapid employment growth and reaching 21 full time employees at launch in 2020, including 2 more in the next 6 months.

Keywords: human and machine,international higher education student recruitment,education technology,mobile,university application guidance,application coaching,digital coaching
Focused Ultrasound Therapy Using Robotics Approaches towards 2020 (FUTURA2020)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Italy
Call: FET Innovation Launchpad (H2020-FETOPEN-4-2016-2017, 2017)
Start date: 2018-09-01
End date: 2020-02-29
Duration (months): 18.0
Total project cost (EUR): 99875.0
EU funding (EUR): 99875.0
Participants: 1
Project status: CLOSED

FUTURA2020 aims to exploit the 3-year S&T results of the FP7 European project FUTURA (www.futuraproject.eu) which has been flagged up as a success story and was presented during the European Robotics Forum 2017. FUTURA2020 represents a fundamental step in the path for bringing the robotic platform for Focused Ultrasound Surgery (FUS) developed in FUTURA to the user hands and to the patient bed. FUS is the paradigmatic example of non-invasive surgical approach: it relies on thermal effects and mechanical cavitation produced by focused US beams, without skin incisions or ionizing radiation. However, FUS suffers from an important drawback, i.e. the limited flexibility in therapy delivery, which narrows the applicability to non-moving and non-essential organs, mainly under MR imaging. Considering robotics, image guidance, machine learning and navigation techniques as the tools to overcome these limitations, FUTURA has developed a versatile and flexible robotic platform able to guarantee high robustness, adaptability and precision of therapy, as well as improving safety and acceptability of multifunctional robotic platforms in the surgical theatre. FUTURA2020 has the concrete objective of increasing the TRL of the developed platform from 5 to 7. The FET Launchpad support will be devoted to perform preclinical in-vivo tests on animals and to activate an industrial oriented process More specifically, the in-vivo trails will boost the credibility of the results obtained up to now: they will solicit interest also from investors, who are needed for supporting the next developments towards human pilot trials and certification. In this endeavour, the FUTURA2020 coordinator will gather the best skills also available in the previous FUTURA Consortium, with ad hoc tasks. Even if the FET Launchpad support is financially limited, it is the most appropriate and timely action for making a not incremental step for the final clinical adoption of FUTURA

Keywords: focused ultrasound surgery,computer assisted robotic platform,high intensity focused ultrasound,pre clinical assessment
BUILDING LINKS BETWEEN EUROPE AND AFRICA IN PERSONALISED MEDICINE (EU-Africa PerMed)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Coordination and support actions
Countries involved: Egypt,Italy,South Africa,Spain,Tanzania, United Republic of,France,Senegal,Kenya
Call: Actions in support of the International Consortium for Personalised Medicine (H2020-SC1-2020-Single-Stage-RTD, 2020)
Start date: 2021-02-01
End date: 2025-01-31
Duration (months): 48.0
Total project cost (EUR): 1999637.5
EU funding (EUR): 1999637.5
Participants: 13
Project status: SIGNED

The EU-Africa PerMed project has the final objective of integrating African countries into ICPerMed activities as a means to contribute to the implementation of Personalised Medicine (PM) in the the global context, fostering joint PM projects and programmes between Europe and Africa, and strengthening bilateral EU-AU science, technology and innovation (STI) in health. On the long run, incorporating African countries in the global PM research agenda can contribute to shorten existing health disparities between developed and developing countries, as well as facilitating access of African countries to new tools and technologies that have the potential make health care more efficient and equitable. The specific objectives set for the project are 1)To identify, contact and engage with relevant health-related organizations in Africa to interact and work with throughout the project; 2)To explore and analyse with relevant stakeholder, the potential for and advantages of collaboration in PM between Africa and Europe, identifying areas of mutual interest; 3)To foster and facilitate the integration of health research funding and policy organisations from AU countries in the ICPerMed consortium and participate in the ERA PerMed funding scheme; 4) To seek synergies and align with activities of ongoing EU-Africa research programmes and other by-regional policy actions (such as EDCTP); 4)To carry out capacity building and training activities addressing relevant PM issues for Africa and 5)To contribute to raising awareness of PM and the benefits of a closer inter and intra-regional collaboration, in order to advance in the implementation of PM. As COVID19 is showing, addressing global health challenges is only possible by building and strengthening international scientific cooperation. EU-Africa PerMed will work towards fostering a stronger global collaboration in PM, and by this, better addressing global health challenges such as infectious diseases and future pandemics.

Keywords: europe,africa,icpermed,erapermed,international collaboration in sti,research standards,eu au policy dialogue
Bacteria-mucin interactions – Shaping intestinal epithelial responses in health and disease (Bac2MUC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The intestinal microbiota consists of beneficial commensal bacteria and pathobionts that cause inflammation. The intestinal mucus layer dictates how specific members of the microbiota affect health and disease. The mucus layer consists of soluble mucins and epithelial transmembrane (TM) mucins that regulate host responses. The molecular mechanisms as to how the intestinal microbiota affect the functions of TM mucins is largely unknown. My recent work shows that TM mucin MUC1 is a key receptor for Salmonella invasion into polarized epithelial cells. We also discovered that MUC13 is a central regulator of epithelial barrier formation. I hypothesize that bacteria-mucin interactions shape epithelial responses by stimulating healthy barrier formation, driving inflammation or mediating bacterial invasion. My aim is to unravel molecular mechanisms via which distinct bacterial species regulate the functions of TM mucins MUC1 and MUC13 in the intestine. The key objectives of Bac2MUC are to: 1. Identify commensal and pathogenic bacteria that target TM mucins 2. Elucidate TM mucin signaling pathways activated by commensal and pathogenic bacteria 3. Determine the function of TM mucins during inflammation and invasion 4. Utilize bacteria-TM mucin interactions to unravel healthy epithelial barrier regulation I will use an innovative large-scale screening platform to identify novel bacteria-mucin interactions. TM mucin signaling pathways during bacterial interaction will be characterized by sortase technology. Cutting-edge technologies such as CRISPR/Cas9 genome editing and advanced microscopy will be applied in established bacterial infection assays with intestinal cell lines and organoids. Bac2MUC is an ambitious and ground-breaking project that will address, for the first time, the complex interplay between intestinal bacteria and TM mucins. This project will contribute to clinical strategies that prevent intestinal inflammation and improve mucosal barrier function.

Keywords: transmembrane mucins,muc1,muc13,mucus layer,intestinal microbiota,epithelial responses,commensal and pathogenic bacteria,inflammation,impact of bacteria mucin interactions
Attosecond X-ray Molecular Dynamics and Strong-Field Control (ATTO-CONTROL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-20
End date: 2022-05-19
Duration (months): 36.0
Total project cost (EUR): 245732.16
EU funding (EUR): 245732.16
Participants: 2
Project status: CLOSED

The development in recent years of ultrashort light sources in the attosecond regime has opened new avenues for the investigation of electronic and nuclear dynamics. In particular, the current development of UV-XUV or UV-X-ray pump-probe schemes with subfemtosecond temporal resolution represents a doorway to study chemical reactions in excited states of molecules in real-time, including biological reactions, such as e.g. those related to DNA damage and mutations. The aim of this project is to understand and ultimately control photochemical reactions in excited states of polyatomic molecules, especially relating to two fundamental processes in biology and chemistry: (i) cis-trans photoisomerization and (ii) the internal conversion of pi-pi*/n-pi* states in organic chromophores. Two top-notch experimental methods will be employed to achieve this goal: attosecond X-ray transient absorption (X-ATAS) at the University of California at Berkeley (United States), where the fellowship will be carried out under the supervision of Prof. S. Leone, and three-color femtosecond pump-probe velocity map imaging (fs-VMI) at Complutense University of Madrid (Spain), where the incoming phase will take place under the supervision of Prof. L. Bañares. The project is divided in three specific objectives and work-packages. Firstly, the powerful X-ATAS method will be employed to observe dynamics in real-time through individual carbon atom spectra and disentangle the dynamics underlying these processes in two polyatomic targets –nitroethylene and transbutadiene– and two bio-relevant ones –thymine and citosine. Secondly, attosecond control in real-time using X-ATAS on the pi-pi*/ n-pi* internal conversion in thymine will be performed in a pioneering experiment. Finally, effective femtosecond control with fs-VMI of these processes in nitroethylene and trans-butadiene, molecules of interest for technologies, will be performed based on the relevant results from the X-ATAS experiments.

Keywords: attosecond chemistry,femtochemistry,photochemical dynamics,chemical control
Innovative RUNning gear soluTiOns for new dependable, sustainable, intelligent and comfortable RAIL vehicles (RUN2Rail)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Spain,Italy,Italy,Germany,Spain,Italy,Italy,Germany,Italy,Sweden,Belgium,France,United Kingdom,United Kingdom,Portugal
Call: Tools, methodologies and technological development of the next generation of Running Gear (H2020-S2RJU-OC-2017, 2017)
Start date: 2017-09-01
End date: 2019-09-30
Duration (months): 25.0
Total project cost (EUR): 2732463.75
EU funding (EUR): 2732463.75
Participants: 17
Project status: CLOSED

The RUN2RAIL project will explore an ensemble of technical developments for future running gear, looking into ways to design trains that are more reliable, lighter, less damaging to the track, more comfortable and less noisy. These innovations will be proposed in the form of case studies supported by the methods and tools elaborated in the project. The project develops across four thematic Work Streams: Innovative sensors & condition monitoring, Optimised materials & manufacturing technologies, Active suspensions & mechatronics, Noise & Vibration. In these four areas, the project will provide a coordinated set of technical key contributions including (but not limited to): - smart sensors and smart running gear components with self-diagnosing capability; - use of novel materials and manufacturing methods in combination with intelligent / active suspensions to enable non- conventional running gear concepts; - identification of efficient fabrication processes for the running gear (3D metal printing, automated tape layering of composite materials); - assessment of existing off-the-shelf technology for active control coming from other sectors; development of a novel and comprehensive methodology for predicting the transmission of noise and vibration from the running gear to the carbody. Within the four workstreams, the project will also perform a preliminary evaluation of the related regulatory and standardisation issues, together with a careful assessment of the impacts of the new solutions proposed. The research conducted will be multidisciplinary, i.e. based on the integration of different branches of engineering such as mechanical, materials, electronic and electrical engineering, and will establish models and formal methods to explore a full set of technological developments, exploiting at best the matching mix of talent and diverse skills offered by the Consortium.

Keywords: innovative sensors,condition monitoring,optimised materials,running gear,vehicle authorisation,active suspension and control technology,noise and vibration,shift2rail
Validation of a Lung Cancer Plasma Reflex Test Using Epigenetic Biomarker for Cancer Detection (proLungPlasma)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Germany
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-2-2014, 2014)
Start date: 2015-07-01
End date: 2017-12-31
Duration (months): 30.0
Total project cost (EUR): 2772527.5
EU funding (EUR): 2772527.5
Participants: 1
Project status: CLOSED

The objective of “proLungPlasma” is the clinical validation of a lung cancer test, which detects DNA methylation of the specific biomarker mSHOX2. Methylation of DNA is an important epigenetic process involved in fundamental biological processes as development and cell differentiation. Aberrant DNA methylation plays a major role in cancer development. Epigenomics is very successfully engaged in epigenetic research since 1998 resulting in an outstanding proprietary platform for epigenetic biomarker discovery for cancer. Epigenomics is now market leader in epigenetic biomarker test kits detecting most frequently occurring forms of cancer as colorectal and lung cancer from different sample materials. Lung Cancer is the most deadly of all cancer diseases. Unfortunately, lung cancer screening by Low Dose Computer Tomography (LDCT) is burdened by unacceptably high false positive rates. The newly developed Epi proLung Plasma Reflex Assay is urgently required as a tool for reducing false positive rates. Therefore, the Epi proLung Plasma Reflex Assay is a highly anticipated pre-requisite for successful implementation of lung cancer screening in Europe. This business innovation project will validate the Epi proLung Plasma Reflex Assay for the diagnosis of lung cancer in plasma under the upcoming new IVD regulation. The validation process to be performed in this business innovation project will be used as a blueprint for the standardized validation of all further epigenetic biomarker blood tests. Epigenomics’ established test platform, its product development and regulatory expertise, and the standardized validation process are expected to kick-off further strong growth on major global MDx markets.

Keywords: lung cancer,epigenetics,pcr test kit
Organic Semiconductors Interfaced with Biological Environments (OSIRIS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Switzerland,Switzerland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-08-01
End date: 2022-07-31
Duration (months): 60.0
Total project cost (EUR): 1498275.0
EU funding (EUR): 1498275.0
Participants: 2
Project status: CLOSED

Transducing information to and from biological environments is essential for bioresearch, neuroscience and healthcare. There has been recent focus on using organic semiconductors to interface the living world, since their structural similarity to bio-macromolecules strongly favours their biological integration. Either water-soluble conjugated polyelectrolytes are dissolved in the biological medium, or solid-state organic thin films are incorporated into bioelectronic devices. Proof-of-concept of versatile applications has been demonstrated – sensing, neural stimulation, transduction of brain activity, and photo-stimulation of cells. However, progress in the organic biosensing and bioelectronics field is limited by poor understanding of the underlying fundamental working principles. Given the complexity of the disordered, hybrid solid-liquid systems of interest, gaining mechanistic knowledge presents a considerable scientific challenge. The objective of OSIRIS is to overcome this challenge with a high-end spectroscopic approach, at present essentially missing from the field. We will address: 1) The nature of the interface at molecular and macroscopic level (assembly of polyelectrolytes with bio-molecules, interfacial properties of immersed organic thin films). 2) How the optoelectronics of organic semiconductors are affected upon exposure to aqueous environments containing electrolytes, biomolecules and cells. 3) How information is transduced across the interface (optical signals, thermal effects, charge transfer, electric fields, interplay of electronic/ionic transport). Via spectroscopy, we will target relevant optoelectronic processes with ultrafast time-resolution, structurally characterize the solid-liquid interface using non-linear sum-frequency generation, exploit Stark shifts related to interfacial fields, determine nanoscale charge mobility using terahertz spectroscopy in attenuated total reflection geometry, and simultaneously measure ionic transport.

Keywords: organic bioelectronics and biosensors,conjugated polymers and polyelectrolytes,organic thin films,solid liquid interfaces,ultrafast spectroscopy,terahertz time domain spectroscopy
Big data meeting Cloud and IoT for empowering the citizen clout in smart cities (BigClouT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Italy,Greece,France,France,France,United Kingdom,United Kingdom
Call: IoT/Cloud/Big Data platforms in social application contexts (H2020-EUJ-2016-1, 2016)
Start date: 2016-07-01
End date: 2019-06-30
Duration (months): 36.0
Total project cost (EUR): 1349622.5
EU funding (EUR): 1349622.5
Participants: 9
Project status: CLOSED

As we enter 2016, the world is facing a number of critical challenges such as global warming, economic crisis, security threats, inequality, natural disasters and ageing society. Urban areas are particularly affected, given that the world population is increasingly concentrated in those areas. ICT solutions have the potential to change the world and improve the quality of life and security of its citizens. In particular, IoT, cloud and big data are today’s key enablers for increasing the efficiency in using shared urban infrastructure, economic and natural resources. The overall concept of the BigClouT project is to give an analytic mind to the city by creating distributed intelligence that can be implanted in the whole city network. The unprecedented number of connected things and the associated big data naturally raise new technical challenges in terms of interoperability, scalable and online data processing, actionable knowledge extraction, self-management, security and privacy. The BigClouT project is bringing together resources and knowledge necessary from prestigious European and Japanese institutions for tackling those challenges. BigClouT will leverage the results of the ClouT project and bring them several steps further and add, in particular, distributed intelligence with edge computing principles, big data analytics capability and self-awareness property. The BigClouT platform will be deployed and validated in 4 pilot cities in the project, Grenoble, Bristol, Tsukuba and Fujisawa. BigClouT gives a particular importance to the involvement of citizens during the whole lifetime of the project, from use case definitions to validation. BigClouT has also the ambitious objective of creating a community of external end-users to build their own applications/business on top of BigClouT tools and platform, and to maintain alive this community during the project and beyond, which will ensure the sustainability of the results of the ClouT and BigClouT projects.

Keywords: big data,edge computing,internet of things,machine learning,distributed intelligence,smart cities,citizen empowerment