Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Under the guidance of Mary: “Moriscos” and “Indios” against the expansion of the Spanish Empire and the politics of Marian devotion. (UGM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 261380.64
EU funding (EUR): 261380.64
Participants: 2
Project status: SIGNED

The focus of my research project is the political implications of Marian devotion in the Early Modern Iberian World and its role in the colonial management of “native” communities of “Moriscos” and “Indios,” subdued since the end of the 15th century by the expansion of the Spanish Empire. In this sense, my study proposes a “political” reading of the development of Marian devotion in the Iberian Peninsula and its American colonies, analysing how its particular characteristics and evolution reflected the progressive transformation of the Spanish imperial project and encoded diverse and changing conceptions of the role of these “native” communities in the imperial fabric. Through the comparative study of the representation of “Indios” and “Moriscos” in the collective imagery, official documentation and religious literature, my research tries to question the role of the Virgin and her imagined relationship with these communities in the debate over the ability of “native” populations to integrate themselves into the colonial regime as “faithful subjects” and “good Christians”, and the place of their culture and religious sensibility in the configuration of the emerging colonial culture. Through the analysis of the intellectual and artistic products commissioned by “Christianized” Morisco and Mesoamerican elites, my project tries to elucidate how “native” communities and especially subaltern elites, facing the progressive erosion of their rights and privileges, used Marian devotion to prove the value of their cultural heritage, lineage and memory and to reclaim their place in the colonial society. Similarly, my research seeks to understand how “native” communities transformed the Virgin into a “political” symbol, through which they could legitimise their understanding of Christianity and o promote an alternative and more “inclusive” conception of the Spanish Empire against the growing acculturating and homogenising pressure of the Empire and the Reformed Church.

Keywords: spanish empire,moriscos,indios,marian cult,politics of devotional culture,subaltern elites,native communities,comparative history,alterity,local religiosity,acculturation,catholic church
FINGERprinting cold subduction and Plate Tectonics using key minerals (FINGER-PT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Portugal
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 2499961.0
EU funding (EUR): 2499961.0
Participants: 1
Project status: SIGNED

Plate Tectonics (PT) is a well-established framework of moving plates made of oceanic and continental lithosphere. The main driving force of this system is the slab pull, a force imposed as the older and colder subducting plate sinks into the asthenosphere at convergent boundaries, producing Low Temperature/High Pressure (LT-HP) metamorphic rocks. Although our understanding about PT has improved in the last decades, there are major unknowns remaining, namely when and how its onset took place, a highly controversial topic. The record of LT-HP metamorphic rocks becomes continuous only from 850-750 Ma onwards, but recent evidence of these rocks at 2100-2000 Ma suggests a similar Tectonic regime operated at this time as well. An outstanding question arises: did Plate Tectonics, as we know it today, begin to operate only 850Ma ago or did this change take place much earlier but disappeared as the result of a preservation bias affecting LT/HP rocks? FINGER-PT will test this hypothesis using detrital minerals in sedimentary rocks that can track older LT-HP. Key minerals that can retain pressure, temperature, and age (P-T-t) information will be used, applying chronothermobarometric tools. Through a multidisciplinary approach, we will (i) combine the existing tools with new ones to obtain reliable P-T-t conditions; ii) test these tools and study the survival of eroded LT-HP terranes via mineral analyses in analogue modern sediments draining an exposed subduction zone; iii) identify and sample the most appropriate units, whose detrital minerals record the last 1000 to 4000 Ma, to trace the secular evolution of cold subduction. The emerging new tools from FINGER-PT, some that push current technological boundaries, will be widely applied by other petrologists. Establishing when modern-day PT began will influence the geodynamic mechanisms proposed for the early Earth (e.g. sluggish tectonics), forcing a shift of current conceptual models on the evolution of Earth systems.

Keywords: evolution of plate tectonics detrital heavy minerals petrogeochemical tools early earth dynamics experimental petrology rutile titanite garnet
Dissecting renal metabolic reprogramming heterogeneity to target kidney fibrosis (MetaboKID)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: SIGNED

Chronic kidney disease (CKD) affects 10% of the population and fibrosis driven by excessive accumulation of extracellular matrix (ECM) is the hallmark of CKD. Myofibroblasts are the key ECM producing cells and are activated by cross-talk with injured proximal tubule anChronic kidney disease (CKD) affects 10% of the population and fibrosis driven by excessive accumulation of extracellular matrix (ECM) is the hallmark of CKD. Myofibroblasts are the key ECM producing cells and are activated by cross-talk with injured proximal tubule and immune cells. Although a derangement in fatty acid oxidation (FAO) of tubular epithelium is crucial in the pathophysiology of CKD, the metabolic rewiring of kidney myofibroblasts remains elusive. Our preliminary observations suggest that cell type-specific metabolic shifts could define new cellular subpopulations with a differential role in the fibrogenic response. To understand this, the following objectives have been defined: 1. To decipher the role of FAO in myofibroblasts during kidney fibrosis; 2.To dissect metabolic changes as important drivers of kidney fibrosis and CKD; 3. To validate key metabolic pathways in complex ex vivo models of kidney fibrosis. To address these aims, I will map the genetic and metabolic spatio-temporal features of kidney fibrosis by a combination of cutting-edge multi-omics technologies at large scale (Spatial single cell ATAC sequencing for transcriptomics and Space M for metabolomics). This will be complemented by advanced computational analyses and modeling, using CKD human biopsies and mouse renal samples from available genetic models for myofibroblast tracing and FAO enhancement. Innovative in vitro systems (cell coculture and kidney organoid systems) will be used to identify and target cell type-specific metabolic reprogramming. Strategies based on the modulation of these metabolic shifts will provide a firm basis for novel, metabolism-oriented therapeutic approaches against renal fibrosis and CKD.

Keywords: kidney disease,fibrosis
reliable durable high power hydrogen fueled PEM Fuel Cell stack (RealHyFC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: France,Germany,Denmark,Sweden,Slovenia,Austria
Call: Development and optimisation of reliable and versatile PEMFC stacks for high power range applications (HORIZON-JTI-CLEANH2-2022-2, 2022)
Start date: 2023-06-01
End date: 2026-12-31
Duration (months): 43.0
Total project cost (EUR): 3487157.5
EU funding (EUR): 3487156.0
Participants: 9
Project status: SIGNED

RealHyFC gathers key actors of the whole PEMFC value chain to overcome crucial hurdles towards industrial empowerment on heavy-duty (HD) applications, mainly for land transport while expecting benefits for ships, trains or aircrafts. The technical issues precluding a rapid and wide adoption of PEMFC on HD applications are linked with reliability and versatility of the stacks. RealHyFC will bring knowledge and experimental feedback on two key levels: stack design and stack operation. Regarding stack design, carbon and metallic technologies will be investigated on efficiency and lifetime issues, local degradation and mechanical properties. Unpreceded direct comparison will be possible thanks to the adaption of an open-design made for metal to carbon-composite case, with developments on bipolar plates and balance of stack. RealHyFC will eventually deliver a public open-design platform with demonstrated high efficiency and durability under HD application conditions. For long-lasting operation, the diagnostics and monitoring of stacks are crucial to preclude damages on performance or components: RealHyFC will bring new solutions based on improved physical degradation models allowing to develop virtual sensors algorithms to optimize fuel cell operating conditions and hybridization strategy. Final validation, by demonstration of lifetime improvements thanks to an adjusted control chain, will be done following system-representative simulation and experimental approaches towards durability-oriented operation in HD environment. The outcomes of the project are strongly linked with the industrial world and settings carrying relevant PEMFC use. RealHyFC will enable the development of cost-competitive, reliable and durable fuel cell technology. To this extend, an exploitation strategy will foster industrial empowerment, alongside dissemination and communication towards technical audience and large public.

Keywords: pemfc heavy duty graphite stack metallic stack durability
Reverse Healthcare Supply Chains for Circular Economy (REHEAL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: Pre-Commercial Procurement
Countries involved: United Kingdom,Spain,Denmark,Poland,Greece,Belgium
Call: Pre-commercial procurement for environmentally sustainable, climate neutral and circular health and care systems (HORIZON-HLTH-2024-CARE-14, 2024)
Start date: 2025-09-01
End date: 2029-08-31
Duration (months): 48.0
Total project cost (EUR): 7358767.5
EU funding (EUR): 7358767.5
Participants: 8
Project status: SIGNED

REHEAL addresses the pressing challenge of transitioning healthcare supply chains from linear to circular models, aligning with the EU’s Green Deal ambitions of zero pollution, climate neutrality, and circularity. Linear supply chains, dominated by single-use medical devices, lead to significant waste, supply chain vulnerabilities, and substantial carbon emissions. By leveraging innovative digital tools, REHEAL aims to enable sustainable procurement, refurbishment, recycling, and resource recovery in healthcare systems. Coordinated by the University of Edinburgh’s Data-Driven Innovation (DDI) group, REHEAL unites a formidable Buyers Group of five healthcare systems from Scotland, Galicia, Denmark, Greece, and Poland. This group represents 261 hospitals, employs nearly 300,000 healthcare professionals, and serves over 17 million citizens. Complementing this are the consortium’s partners, including EIT Digital, Europe’s largest digital innovation ecosystem, and leading healthcare researchers, policymakers, and suppliers, ensuring multidisciplinary expertise and robust implementation capabilities. The project deploys a PPC strategy, enriched by CivTech methodologies, to co-design and pilot innovative reverse supply chain solutions with 20 suppliers. The top-performing solution will undergo wide-scale validation and deployment across the Buyers Group, fostering new market opportunities for startups and SMEs. Additionally, REHEAL will establish a Community of Followers, engaging 20+ healthcare systems in a Public Procurement of Innovation roadmap, scaling the impact across Europe. Expected outcomes include measurable reductions in waste and emissions, cost savings for healthcare systems, and enhanced supply chain resilience. By transforming procurement practices, REHEAL accelerates the adoption of circular economy principles, laying the groundwork for an EU-wide market for sustainable healthcare innovations, driving both environmental and economic benefits globally.

Keywords: circular economy,reverse supply chains
Luxembourg Hydrogen Valley delivering integrated full-chain sustainable hydrogen ecosystem with technical, economic, social and environmental benefits and superior replicability. (LuxHyVal)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Luxembourg,Germany,Spain,Czechia,France,Australia,Ukraine
Call: Hydrogen Valleys (small-scale) (HORIZON-JTI-CLEANH2-2022-2, 2022)
Start date: 2023-11-01
End date: 2029-01-31
Duration (months): 63.0
Total project cost (EUR): 39108678.75
EU funding (EUR): 7999998.64
Participants: 20
Project status: SIGNED

LuxHyVal launches a flagship hydrogen valley in Luxembourg to boost the penetration of hydrogen by deploying green hydrogen initiatives across the entire value chain from local production to utilisation, including storage and distribution for a range of applications targeting industry and mobility, while also aiming to connect with existing/planned infrastructures. Business models, regulation and commercial negotiations are defined. Safe design and operation are ensured to deliver certified green hydrogen. LuxHyVal produces 650 ton/y that are used by several end-use applications in the mobility (i.e., private & public buses, light industrial vehicles) and industry (i.e., metal and glass manufacturing) sectors using 69% and 31% of the produced hydrogen, respectively. Strong commitment of key commercial actors along the entire value chain and political support in line with the Luxembourg Hydrogen Strategy aimed at fully decarbonising the industrial sector before 2030 is ensured as demonstrated by 80% co-financing from external sources. It generates different investments exceeding 38M€. Significant econonomic, social, environmental and political impacts are achieved. Digital Twinning for optimal planning and operation is delivered to support upscaling and replication, while public perception and professional upskilling deliver social benefits and equip the workforce with the needed competences. Lastly, the lessons learned and solutions are replicated in 2 Follower Valleys in Central (CZ) and Eastern (UA) Europe. The consortium include 19 partners from 7 countries (6 from Europe plus Australia) aligned with the Clean Hydrogen Mission covering the entire value chain, including energy engineering/integrator, network operators, technology providers, supplier of green electricity, end users in mobility and industry and RTO experts in digitalisation, public acceptance, environmental assessments, innovation management, and replicators from the follower valleys.

Keywords: green hydrogen uses,hydrogen integrated ecosystem,sector coupling,industry decarbonization,fch buses
Chaperone action - a thermodynamic view (CHAPLIN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The goal of the proposed study is to obtain a fundamental understanding of the molecular mechanism and thermodynamics of chaperone action. Chaperones are critical components of all organisms and serve to ensure a healthy state of the proteome. The proposal concerns a class of chaperones that increases the solubility of client proteins. The activity of these chaperones exhibits a number of crucial but poorly understood features; for instance, there is a remarkable specificity in action combined with promiscuous recognition across sequence space. These features are challenging to achieve through molecular design and raise the question of the general physical principles which govern chaperone activity. Our research aims to reach a general understanding, beyond specific effects, and we will study nine binary combinations of three chaperones and three client proteins. Our strategy is to first characterize in detail the aqueous solubility and self-assembly of each chaperone alone including the phase behaviour. With this knowledge, and our existing deep understanding of client self-assembly, we turn to chaperone action to study the thermodynamics of chaperone-client mixtures to determine the phase behaviour, structure of chaperone-client co-assemblies, the mixing stoichiometry and quantitative equilibrium parameters. We use state-of-the art scattering, spectroscopy, and microscopy methods and develop new methodology. Common to the field is a mechanical view and search for specific sites in chaperone and client proteins that mediate their mutual interaction, but the promiscuity makes us question whether such sites exist. We take a new approach, not pursued by others in the field, in that we search for general molecular and thermodynamic principles of chaperone action. Our results may guide the design of small molecules that operate according to the same principles, which can serve as therapeutics toward some of the most devastating diseases affecting humans.
Lights in the nightsky and Ozone loss: Unravelling Atmosphere forcing from space with Radar, optics, and Novel citizen science (LOUARN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Finland
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 2459229.0
EU funding (EUR): 2459229.0
Participants: 1
Project status: SIGNED

This project will address a major unsolved question in geosciences: how strongly is our planet's atmosphere subjected to forcing from space? The mesosphere–lower-thermosphere–ionosphere (MLTI) is the boundary of the Earth environment, and as such it undergoes forcing from above, in particular at high latitudes. The forcing includes charged particle precipitation from near-Earth space, associated with electric currents producing Joule heating in the upper atmosphere. It also involves trace gas production in the mesosphere which catalytically destroy ozone – including down to the stratosphere when long-lived species descend to lower altitudes – as well as neutral wind changes and atmospheric wave generation. However, these effects in terms of MLTI energetics, chemistry, and dynamics are largely unquantified, leading to unknown uncertainties in lower atmosphere and climate model results. The LOUARN project will bridge this gap by adopting a multidisciplinary approach, combining knowledge and methods from space physics and atmosphere sciences. With LOUARN, I aim at unravelling the MLTI forcing from space by using cutting-edge ground-based instruments measuring both the ionised medium and the neutral gas properties, together with numerical simulations of the upper atmosphere and novel citizen science methods. My objectives are to (1) quantify the energy deposited into the MLTI during geomagnetic disturbances, (2) provide accurate upper-boundary conditions on the ozone balance for atmosphere and climate models, and (3) characterise the wind and atmospheric wave response to this driving from space. My expertise in ionospheric physics and its driving from near-Earth space processes, along with my leadership in auroral citizen science, puts me in an ideal position to address this ambitious challenge. I aim at a breakthrough in atmosphere–ionosphere–space couplings with impacts on atmosphere and climate sciences and on solar–terrestrial physics.

Keywords: mesosphere lower thermosphere ionosphere,auroral physics,particle precipitation,ionospheric currents,subauroral processes,citizen science,mesospheric and stratospheric ozone,upper atmospheric waves,substorm