Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Creating Knowledge (CreateKnow)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

In this project I want to unravel how we build-up and update our knowledge networks depending on the amount of previous experience we have by testing my new theory on experience dependent learning. Current theory postulates memories to be stored initially as sets of neural representations spanning the hippocampus and weakly interacting neocortical modules. The spontaneous reactivation of new memories during a consolidation phase, would lead to strengthening of the neocortical memory trace. Consequently, pre-existing knowledge is proposed to be coded in the brain as a cortical network of neurons that allows for more efficient consolidation of new information. I recently developed a new theory, proposing that the existence of previous knowledge and therefore the extent of the cortical memory network, is a gradient of experience instead of being either present or not. The size and complexity of the knowledge network would influence where in the brain memories are encoded and how fast they are consolidated. I propose combining my innovative behavioural paradigm – the HexMaze - that enables investigatory access to various levels of experience, with different techniques in three species to test this theory. In mice, with immediate early gene expression techniques to visualize and manipulate the brain-wide memory network with the resolution of individual neurons. In rats, with electrophysiology to measure and manipulate memory reactivations during sleep as the mechanisms to enable consolidation. In humans, with targeted memory reactivation and magnetic resonance imaging to follow the evolution of learning over one year. The combination of species with their respective methods enables to observe effects as well as test for causality. The unique combination of meaningful behaviour with appropriate, precise techniques would provide ground-breaking insight into how we create and update our knowledge networks and change the way we view and test memory.

Keywords: sleep,memory reactivations,schemas,previous knowledge,memory consolidation
Radical approach to modeling electron conducting polymers (E-RADICAL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 216240.0
EU funding (EUR): 216240.0
Participants: 2
Project status: SIGNED

The promise of organic electron-conducting polymers creates outstanding opportunities for flexible, low-cost, and sustainable optoelectronics and energy storage devices. An emerging class of electron-conducting polymers is non-conjugated radical-containing polymers (RAPs). These are organic polymers with a non-conjugated backbone and pendant-stable radical sites. RAPs successfully transport charges without relying on π-conjugation, instead using redox reactions between the pendant radical groups. This introduces a new paradigm in polymer-based electron transport. However, our understanding of these materials is incomplete and the molecular mechanisms underpinning their properties remain elusive. In E-RADICAL, I will advance our understanding of RAPs through the development of a novel multiscale modeling approach that combines molecular dynamics, quantum dynamical methods, and machine learning. This approach will enable, for the first time, quantum-dynamically accurate and computationally efficient simulations of charge transport in realistic, disordered RAP morphologies. The proposed multiscale approach will be used to perform a comparative study of charge transport in highly conductive RAPs and conjugated polymers, extracting underlying principles governing efficient charge transport. Finally, I will generate the first computational condensed-phase library of RAPs, allowing me to deduce structure-property relationships and formulate design guidelines for this emerging class of materials. In summary, E-RADICAL will provide detailed and unprecedented understanding of the molecular mechanisms driving charge transport in RAPs, thereby informing the rational design of improved materials with ramifications for the development of devices that enable a future with clean and affordable energy.

Keywords: radical containing polymers,mixed quantum classical modeling,multiscale modeling
A new cardioprotective drug for acute treatment of myocardial infarction (CardioProtectMI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 3770625.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Ischemic Heart Disease kills more than 1.7M people/year in the EU, the vast majority via a heart attack (Myocardial Infarction - MI). Heart failure (HF) is the major cause of death after MI with a prevalence of >26M individuals globally. While current treatment involving restoration of blood flow to the heart saves the MI patient´s life it also causes additional damage to the heart through an inflammatory reaction (reperfusion injury). ResoTher’s leading drug candidate, RTP-026, is an immunomodulating therapeutic aimed at resolving inflammation triggered during MI, thereby reducing damage to the heart and significantly decreasing risk of HF and death. Pre-clinical data suggests RTP-026 could reduce post-MI HF by >20%. A Phase I study has been conducted to determine safety and tolerability of RTP-026 in Healthy Volunteers. With the EIC we aim to validate RTP-026 clinical effectiveness by means of a Phase IIa patient proof of principle study and Phase IIb proof of concept study.

Keywords: cardioprotective drugs,immunomodulators,cardiovascular diseases,resolution of inflammation,heart failure,myocardial infarction
Lighthouse for Atlantic and Arctic Basin (PHAROS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Spain,Italy,Belgium,Portugal,Ireland,Denmark,Netherlands,France,Greece,Ukraine,Norway,Romania
Call: Atlantic and Arctic sea basin lighthouse – Addressing climate change and human activities threats to marine biodiversity (HORIZON-MISS-2023-OCEAN-01, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 9972718.75
EU funding (EUR): 9492212.5
Participants: 27
Project status: SIGNED

The EU has set bold quantified and measurable targets to achieve its Ocean Mission objectives relating to protecting and restoring marine ecosystems and biodiversity (Mission Objective 1); preventing and eliminating pollution of our ocean (Mission Obj. 2); and making the sustainable blue economy carbon-neutral and circular (Mission Obj.3) by 2030. The EU Mission Implementation Plan has two demanding, but necessarily near-term phases: the first ‘development and piloting’ phase by 2025, and the second ‘deployment and upscaling’ phase from 2026-2030. PHAROS will be the logical stepping stone bridging Mission Phase 1 ‘development and piloting’ and the second ‘deployment and upscaling’ phase from 2026-2030. • PHAROS will have three demos in the Atlantic using a combination of newly developed innovative NBS and IMTA, tailored to the local context, resulting in multiple biodiversity and ecosystem restoration benefits (Mission Phase 1). These demos will also leverage key Mission projects including Ocean Citizen, Climarest, and Ultfarms (Mission phase 2). • PHAROS will also partner with H2020 ECOTIP to leverage and extend its project in a demo to reduce invasive species in Iceland with eDNA monitoring (Mission phase 1 and 2). • PHAROS will extending (TRL advancement) and rolling out leading Mission projects across the AA basin including Prep4Blue MPA platform and network, Nettagplus and Remedies Fisher Guardian and Citizen Litter Entrepreneur programs, and Probleu EU Blue School Network platform for education(bridge to phase 2) PHAROS will establish Living Labs, early in the project in each demo and replication region, securing participation for its co-creation approach, across all relevant and necessary actors including different levels of government, researchers and innovators, education institutions, small and large, businesses, investors and civil society.

Keywords: stakeholder engage,living labs,mpa managers and corridors,marine litter,net tagging,litter entrepreneurs,integrated multi trophic aquaculture,artificial reef,digital twin,replication plans
Deciphering the role of protein S-palmitoylation in skeletal muscle physiopathology (MyoPALM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Switzerland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 320924.16
EU funding (EUR): 320924.16
Participants: 2
Project status: SIGNED

Duchenne muscular dystrophy (DMD) is the most prevalent form of childhood muscular dystrophy, affecting approximately 1 in 3500 newborn boys. DMD patients experience early-onset and rapidly progressive muscle weakness, leading to the loss of mobility and premature death. The burden of muscular dystrophies extends beyond the physical challenges faced by patients, indeed it poses significant social and economic implications, impacting patients’ quality of life, necessitating social welfare support and incurring substantial healthcare costs. So far there is no cure for DMD, emphasizing the urgent need to intensify research efforts aimed at uncovering new pathomolecular mechanisms and developing treatment strategies. Protein lipidation, especially protein S-palmitoylation, has gained attention in several diseases, but its role in skeletal muscle function and dystrophic conditions remains completely unexplored. MyoPALM is an innovative project that aims to bridge this knowledge gap by investigating the contribution of protein S-palmitoylation in adult skeletal muscle function. This will be accomplished through in vivo manipulation of the enzymes involved with this pathway and using cutting-edge palmitoyl-proteomic approaches. Furthermore, by exploiting the mdx mouse model, we aim to explore the potential role of protein S-palmitoylation in the pathogenesis of DMD. By unravelling this unexplored perspective, MyoPALM aims to lay the foundation for identifying new druggable targets, paving the way for future therapeutic strategies to benefit DMD patients. Through collaboration between the École Polytechnique Fédérale de Lausanne (CH) and the University of Padova (IT), the applicant seeks to reinforce his technical skills and scientific knowledge, aspiring to become an independent researcher within the European Union.

Keywords: skeletal muscle duchenne muscular dystrophy protein s palmitoylation protein s acylation
Sustainable station-keeping systems for floating wind (TAILWIND)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Spain,United Kingdom,Netherlands,Denmark,Norway,Belgium,Italy,Portugal
Call: Critical technologies for the offshore wind farm of the Future (HORIZON-CL5-2023-D3-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 5586730.71
EU funding (EUR): 5586730.71
Participants: 16
Project status: SIGNED

To meet EU net zero targets requires a six times increase in offshore wind deployment rate, primarily in deep seas where floating offshore wind (FOW) is needed. To achieve this growth requires FOW to be economic, sustainable and supported by a wide supply chain. TAILWIND is focussed on station-keeping systems of FOW, which comprise mooring lines and anchoring systems. The project will unlock identified opportunities for cost reduction, reduced environmental impact and material use, and also supply chain diversification. TAILWIND will integrate new experimental evidence, novel technologies and innovative methodologies, across mooring lines and anchors, and will quantify the resulting benefits for the overall floating system design. All innovations will be sustainable-by-design, integrating environmental, societal and economic benefits. For mooring lines, new synthetic rope technologies will be mechanically and chemically tested to demonstrate their suitability for small-footprint ‘taut’ moorings, validating new response models. For anchoring, geotechnical centrifuge testing and advanced soil element testing will underpin two advances: (i) new response models for the long-term loading particular to FOW, and (ii) the validation of novel anchors types including cluster anchors that are “silently” installed from small vessels and are suited to shared moorings. The new technologies for mooring lines and anchors will allow smaller and lighter station-keeping systems, manufactured and installed by a wider supply chain. TAILWIND will distill the models into system optimisation tools, unlocking further floater optimisation and cost reduction. Finally, an integrated life cycle assessment will quantify the economic, social and environmental impact of TAILWIND’s technologies. TAILWIND unites a diverse consortium of 12 organisations from 8 European countries, located across the emerging FOW development regions, and spanning academia, consulting, construction and manufactu

Keywords: floating wind turbines,mooring systems,cabling systems,anchoring systems,integrated impact assessment
A Simulation-based Framework for Measuring and Modeling the Impact of Attacks on 6G-enabled Massive IoT Networks (REACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,United Kingdom,Greece
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 258789.94
EU funding (EUR): 181152.96
Participants: 3
Project status: CLOSED

As the deployment of 5G networks is in progress, the researchers and engineers are now shifting their attention towards developing the next generation of mobile networks (6G), which is expected to provide Tbps wireless connectivity with ultra-high reliability and extremely low latency (less than 1ms). The new generation of mobile networks, which is expected to be commercialized by 2030, are envisioned to offer much wider range of applications comparing to 5G by interconnecting billions of IoT devices such as extended reality devices, wearable displays, drones, and autonomous vehicles. Definitely, the unprecedented growth of 6G-enabled IoT devices along with the massive emergence of connections in the future 6G communication platform will increase the security vulnerabilities for the 6G-enabled massive IoT networks, leading to a wide spectrum of known and unknown security threats. Therefore, there is an urgent need for developing novel security solutions for massive IoT networks, taking always into consideration their resource-constrained limitations, before they gain the trust of all involved stakeholders and reach their full potential in the 6G era. Toward this direction, REACT aims to develop a simulation-based framework for measuring and modeling the impact of attacks on 6G-enabled massive IoT networks. The proposed simulation-based framework is envisaged to be the first comprehensive IoT security solution which will (a) become publicly available to the IoT security research and industry community for reproducible experimentation and reusability purposes, and (b) also have a high scientific impact by contributing significantly to the efforts against the urgent need for novel security solutions to protect the upcoming 6G-enabled massive IoT networks.

Keywords: security,iot,simulator,security attacks
Performant and Efficient Planar Proton-conducting Electrolysis Reactor (PEPPER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Germany,Austria,France,Denmark,Estonia,Czechia
Call: Innovative proton conducting ceramic electrolysis cells and stacks for intermediate temperature hydrogen production (HORIZON-JTI-CLEANH2-2024, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 3210648.8
EU funding (EUR): 2998152.37
Participants: 10
Project status: SIGNED

The PEPPER project introduces a groundbreaking advancement in hydrogen production technology aimed at meeting the soaring global demand for green hydrogen. At the heart of PEPPER lies the development of a cutting-edge planar Proton Conducting Ceramic Electrolysis Cell (PCCEL) reactor. Operating optimally between 400°C and 600°C, PEPPER's PCCEL technology aligns seamlessly with industrial waste heat sources, maximizing resource utilization. By harnessing two robust planar cell technologies and optimizing material interfaces and manufacturing processes, PEPPER aims to slash electrical energy consumption by up to 20% compared to existing low-temperature electrolysis methods. Led by the Deutsches Zentrum für Luft- und Raumfahrt e.V. (DLR), PEPPER boasts a consortium includes key European research and industrial partners. This collaborative effort ensures a holistic approach to research and innovation, emphasizing real-world applicability. PEPPER's objectives encompass the fabrication of cells up 100cm² in size, the validation of PCCELs under various conditions, the integration into specialized short stacks tailored for PCCEL technology, and the demonstration of long-term operational stability and safety at temperatures ≤ 600°C. Through comparative studies with Solid Oxide Electrolysis (SOEL), PEPPER aims to establish benchmarks for performance and sustainability, guided by comprehensive Life Cycle Assessments (LCA), setting a pathway towards commercialization. By elevating technological readiness from TRL 2 to TRL 4 PEPPER will set the stage for a future where highly efficient and environmentally sustainable hydrogen production can significantly contribute to Europe's energy security and decarbonization goals.

Keywords: electrolysis,critical and strategic raw materials,sustainability,efficiency,high temperature,proton conducting ceramics cells,solid oxide cells,waste heat
RObot traiNing INdependence (RONIN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-09-01
End date: 2026-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

RONIN aims to develop a training toolkit, embedded in a robot-assisted training setup, for supporting adolescents with developmental disabilities (DDs) in achieving independent adult life. DDs hinder access to formal education for about 4 million children in Europe, which, in consequence, compromises their independence later in life. This poses a huge challenge for the affected individuals, their families, and for society. One of the major issues that impedes achieving independence by individuals with disabilities is insufficient support, focused on training social and cognitive skills crucial for leading independent adult life. RONIN proposes a solution which uses the Embodied Learning approach (via “role-plays” with the robot) and targets skills necessary for attaining independent adult life: independence in (i) self-care; (ii) interaction with others; and (iii) facing stressful situations, such as exams or job interviews. RONIN’s training toolkit includes: the training protocol scripts and objects used in interaction, encoded robot behaviours, and graphical user interface (GUI) for the therapists. Involving a robot in the training has the advantage that users can benefit from a robot mediator which offers a non-intimidating, more predictable and reduced in complexity interaction with less social pressure, compared to interaction with another human. For the therapists, the robot removes the burden of repetitive and lengthy “role-plays”, allowing the therapists to focus on monitoring progress of the training. The work plan of RONIN consists in designing the training protocol scripts and objects, encoding the robot behaviours, developing the GUI, integrating all components in the setup, and testing the efficacy of the training protocols with clinical populations. Should the training prove efficacious, it will revolutionise the way support is offered to adolescents with DD, their families and therapists, and will open a pathway to exploitation.