Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
REgeneration of inner ear hair cells with GAmma-secretase INhibitors to regain hearing in patients with sensorineural hearing loss (REGAIN)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Greece,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,Denmark
Call: New therapies for chronic non-communicable diseases (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-05-01
End date: 2019-10-31
Duration (months): 54.0
Total project cost (EUR): 5834340.25
EU funding (EUR): 5834340.0
Participants: 9
Project status: CLOSED

Hearing loss is a chronic non-communicable disease disabling over 328 million adults, and 32 million children worldwide. Sensorineural hearing loss due to loss of auditory hair cells was long thought to be irreversible. However, recent animal studies have demonstrated that pharmacological inhibition of cell signalling via Notch receptors using gamma-secretase inhibitors (GSIs) can regenerate hair cells and partially restore hearing capacity. This novel therapeutic concept provides the first promising lead for actual treatment of hearing loss. Clinical validation of these findings is the next crucial stepping stone in the development of a regenerative therapy for hearing loss. The ambition of REGAIN is to repurpose a GSI molecule for this indication by shifting from systemic to local treatment. The objective of the REGAIN project is to demonstrate and exploit the efficacy of locally administered GSIs to improve hearing through regeneration of inner ear hair cells with a lasting effect. The project will involve 1) the upscaling of GMP production of the clinical GSI candidate, 2) the generation of preclinical data on GSI dosing and local safety, 3) medical ethical clinical trial approval and 4) the demonstration of proof of concept for GSI for treatment of patients with recent onset sensorineural hearing loss. Small molecule drugs targeting the underlying biological causes of hearing loss in a safe way are expected to meet a real medical need for millions of patients, who currently rely on the limited benefits provided by hearing aids or cochlear implants. The partners involved in REGAIN represent the current state of the art in regenerative hearing loss research in the EU. REGAIN will break through that current state of the art, and will advance the first highly promising pharmaceutical treatment of hearing loss through clinical testing.

Keywords: hearing loss,drug,treatment,notch,gamma secretase,presbycusis,noise induced hearing loss,age related hearing loss,pre clinical research,clinical medicine,repurposing
Complex RhEologies in Earth dynamics and industrial Processes (CREEP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Germany,Italy,Iceland,Germany,Italy,Switzerland,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-04-01
End date: 2019-03-31
Duration (months): 48.0
Total project cost (EUR): 3661113.24
EU funding (EUR): 3661113.24
Participants: 20
Project status: CLOSED

The CREEP Innovative Training Network is a training and career development platform for early stage researchers (ESRs) in Geodynamics, Mineral Physics, Seismology, Fluid Mechanics, and Materials Sciences. It aims to structure the collaboration in research and doctoral training between 10 leading academic centers in Earth Sciences in Europe: the CNRS (FR), represented by Geosciences Montpellier and the FAST Orsay, the universities of Bristol, Durham and UCL (UK), Munster and Mainz (DE), Roma TRE (IT) and Utrecht (NL), and as a partner organization: ETH (CH), and 11 partner organizations whose activity encompasses a variety of industrial applications of rheology: oil (Baker Hughes, Schlumberger) and chemical industries (AkzoNobel), glass (Schott) and steel (APERAM) producers, and high-technology SMEs (Rockfield, IGEM, GMuG, MP Strumenti, Geospatial Research, Reykjavik Geothermal). CREEP will provide training to 16 early stage researchers (among which 2 will be self-funded by partner ETH) via a structured program of cross-disciplinary collaborative research, specialized short courses, and workshops. This experience-based training is centered on research projects leading to a PhD that focus on the complex mechanical behavior of Earth materials and its implications for geodynamic and industrial processes. These research projects cover a large spectra of applications from the study of the deformation of the Earth surface (earthquakes) and deep layers to geothermal and petroleum exploration and industrial processes. Through them, the ESRs will acquire skills in experimentation, modelling of deformation at various space and time scales, and seismology. CREEP will also provide the ESRs: (1) essential career-management skills via courses and practical activities aimed to develop their organizational, management and networking skills and (2) experience and understanding of the impact of research for the private sector via secondments in the industrial partners.

Keywords: rheology,deformation,plate tectonics,mantle convection,anisotropy,creep,strength,plasticity,faults,microfracturing,induced seismicity,geothermal,experiments,modelling,seismology
Interracial intimacy in Africa: Afro-European couples, cross cultural transactions, and social changes in Islamic Zanzibar (INTIMIZ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2021-03-31
Duration (months): 36.0
Total project cost (EUR): 264668.4
EU funding (EUR): 264668.4
Participants: 2
Project status: CLOSED

The project “Interracial intimacy in Africa: Afro-European couples, cross cultural transactions and social changes in Islamic Zanzibar” (INTIMIZ), offers an innovative approach to the study of globalization. Built on a bibliography in anthropology, sociology and history, and a case-study in Zanzibar (Tanzania), the project examines the social and cultural dynamics that foster intimate relationships between European expatriates and Africans in contemporary Africa. The project will pursue three objectives: 1) To document European migration to Africa. 2) To analyze the experience of Afro-European intimacy in Zanzibar. At the micro level, I will focus on the dynamics of intimate transactions, whether economic, material or cultural. While the economic issue is currently at the heart of the anthropological understanding of interracial sexuality, little consideration is given neither to the role of love and desire in cross-cultural encounters, nor to the role of cultural transactions between partners. By paying particular attention to affects and symbolic transfers of knowledge, beliefs, values, skills, which characterize the course of intimate life, the project provides a unique view on socialization and on the role of intimacy in possibilities social ascent. 3) To investigate the changes in the local understanding of intimacy. At the macro level, the project will trace the global dynamics that transform conjugality, sexuality, love, and gender roles in the Muslim society of Zanzibar. The project will thus investigate the ways in which Islam informs sexual practices and ideologies of intimacy and gender, and how they are negotiated and transformed with the settlement of non-Muslim Europeans, and mixed marriages. At a societal level, by analysing how people of different racial and religious backgrounds do engage in relationships, INTIMIZ also constitutes an original and effective means to combat racist prejudice.

Keywords: ethnography,zanzibar,expatriation,sexuality,conjugality,intimacy,islam,cultural transactions,mixed couples,tourism
Open Access Single entry point for scale-up of Innovative Smart lightweight composite materials and components (OASIS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Spain,Spain,Germany,Spain,Germany,Germany,Greece,Poland,Greece,France,France,France,Czechia,Netherlands
Call: Open Innovation Test Beds for Lightweight, nano-enabled multifunctional composite materials and components (IA) (H2020-NMBP-HUBS-2018, 2018)
Start date: 2019-01-01
End date: 2022-11-30
Duration (months): 47.0
Total project cost (EUR): 13047006.3
EU funding (EUR): 11757065.75
Participants: 21
Project status: CLOSED

The OASIS project aims at fulfilling market potential of nano-enabled multifunctional lightweight composites, particularly of polymer-matrix and aluminium composites. The OASIS gathers manufacturing capacity of 12 pilot lines for the industrial production of nanoscale structures in unprocessed form, intermediate products with nanoscale features and nano-enabled products as well as other complementary technical (modeling, characterization, toxicology, life cycle assessment) and non-technical services (Business innovation coaching, business planning, access to private capital). These modular services will be provided to companies, particularly to SMEs, to gain access to unique facilities and knowledge without high capital investment. Such support is particularly needed at the crossroads between three KETs (nanotechnologies, advanced materials and advanced manufacturing and processes) and in era of multifunctional products when wide scope of know-how is needed for pre-production or industrial low-medium volume production. The companies will access these wide offering infrastructures by a single-entry point, which will ensure quality customer relationship and management from request formalization to delivery. The multi-pilot line manufacturing capacity of OASIS will be validated by 6 industrial showcases, where lightweight products (TRL6-7) ensure significant impact in construction, automotive, energy and aeronautic industries. The complete OASIS services to SMEs will be demonstrated by 6-12 democases, which will be selected from identified and potential clients by an open call, to ensure highest possible impact. The OASIS will set up economically sustainable open innovation structure, leveraging the previous investments for the full benefit of European companies introducing new added-value products based on nanotechnologies

Keywords: open innovation test bed,nano enabled products,single entry point,open call,lightweight,multifunctional,smart
The genetic and neural basis of reproductive isolation (SpeciationBehaviour)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2025-06-30
Duration (months): 66.0
Total project cost (EUR): 1499540.0
EU funding (EUR): 1499540.0
Participants: 1
Project status: SIGNED

Speciation is a fundamental evolutionary process, which relies on the accumulation of reproductive barriers. These barriers often act before mating, and many taxa remain separate not because they fail to produce viable offspring, but because they ‘choose’ not to mate in the first place. Although the significance of behavioural barriers has long been recognized, an integrated understanding remains elusive: How is behavioural isolation mediated through changes in the sensory systems? Are these changes driven by selection? And what is the genetic and developmental basis of behavioural divergence in natural populations? My research will address these questions to understand how behavioural barriers are generated, both during development and across evolutionary time. This project will be novel in uniting genomic and neurosensory data, with ecological and behavioural studies across a single radiation. Heliconius butterflies offer an excellent opportunity to achieve this as they are a group of closely related species with well-characterised ecologies, high-quality genomic resources, and are emerging as a model of evolutionary neurobiology. These attributes will allow me to address the enduring problem of how natural selection and genetics interact to drive divergence in behavioural preferences. I will determine how components of behavioural isolation vary with ecology, both within and between species; and then explicitly test whether changes in sensory perception and processing in the brain are driven by selection imposed by the external environment. Genetic mapping will allow me to test for a link between changes in the sensory systems and mate choice. By combining these data with expression and functional analyses I will identify genes strongly implicated in the divergence of behavioural preferences. This will lead to novel insights into the developmental and neurological bases of behavioural isolation, a process fundamental to biodiversity.

Keywords: ecological speciation,mate choice,behaviour,genetics
Rapid access to functionalized cyclobutanes via ring expansion strategies (RACING)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-06-11
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Cyclobutanes are common motifs in natural products and are increasingly important in medicinal chemistry since they can orient substituents along precise vectors. However, methods to construct cyclobutanes are less developed in comparison to their smaller and larger rings. Consequently, novel methods to access functionalized cyclobutanes are highly desirable and would be of considerable value for the discovery of new bioactive compounds. In the last decade, the host group and others have contributed significantly to the development of boron 1,2-migration chemistry which has found numerous applications in organic synthesis. Normally, 1,2-metallate shifts in boronate complexes are induced by α-leaving groups or by reactions of alkenyl boronates with halogens, π-acidic metals, or radicals. Herein, we are proposing a fundamentally new strategy to induce 1,2-metallate rearrangement, via a ring expansion of vinyl cyclopropyl boronate complex activated by an electrophile or by photoredox or transition metal catalysis. This novel process would lead to highly versatile boronic ester containing cyclobutanes, which can be transformed into other valuable functional groups. Furthermore, we plan to use chiral ligands in combination with palladium catalysis in this novel process, leading to enantioenriched chiral cyclobutyl boronic esters. These novel methodologies not only benefit from the formation of highly functionalized cyclobutanes, but also lay solid foundations for the development of other ring-expansion induced 1,2-metallate rearrangements. The scope of these processes will be carefully investigated, and mechanistic studies of the photoreaction will be carried out using advanced physical/chemical methods. Finally, this project will enable significant knowledge transfer between the host and researcher, while forging new academic networks within the scientific community.

Keywords: cyclobutanes,boron chemistry,photoredox catalysis,perfluoroalkylation,palladium catalysis
Nanoscale Effects within Biological Membranes caused by Radiation (NanoMembR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-05-16
End date: 2019-07-15
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The NanoMembR project will elucidate key elements of membrane stability under the influence of UV radiation. The stability of biological membranes is of great importance for the structure, homeostasis and functioning of all living systems. Membrane molecules have also attracted, due to their robustness and longevity, strong interest from planetary and space scientists as potential biomarkers for life detection missions to other planets. Membrane damage, perturbation, instability and fragmentation upon UV exposure will be investigated on the nanoscale using cutting-edge infrared nanoscopy. Scattering-type scanning near-field microscopy (s-SNOM) combined with Fourier transform infrared (FTIR) spectroscopy allows to combine spatial information of nanometre resolution with chemical mapping. This novel technique will enable us to study subtle changes in the structural integrity of model membranes and monitor changes in the micro- and nano-domains. In addition, we will be able to correlate membrane stability and membrane composition by intercalating structural and functional modifiers such as sterols, hopanoids and pigments. Upon radiation in oxic environments, the lipid structure of a membrane is known to be altered by peroxidation chain reactions. Under anoxic conditions radiation induced changes in lipid alteration could vary significantly, with intriguing implications for the stability of membrane molecules under different environmental conditions than found on Earth. Understanding fragmentation patterns of membranes and identifying final break-down products will provide scientific support and a database for key biomarkers detectable in remote environments. Results from this work will feed directly into planned experiments on the International Space Station (ISS), which are scheduled on new nanosatellite-technology-based exposure platforms with in-situ infrared spectroscopic capabilities, monitoring membrane stability under the influence of solar and cosmic radiation.

Keywords: biomembranes,photostability,uv radiation,astrobiology,biomarkers,s snom,ftir,space and planetary environment
Commercialisation of Proteus (PROCOMM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-09-01
End date: 2021-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Commercialisation of Proteus. We will develop a case for commercialisation our unique, tribrid (quadrupole mass-filter/collision cell/ multi- collector) inductively coupled mass-spectrometer, dubbed Proteus, built in collaboration with industrial partners Thermo Fisher Scientific. We will explore full workflow applications to open up a business case for turning the prototype into a commercial model. We have already demonstrated its unique capabilities in traditional fields for such instrumentation (Earth, Space and Nuclear sciences), but the rationale for building a commercial instrument is best made by showing its utility in developing a new market in screening large numbers of samples for medical research and possible detection of diseases. Here we will assess the potential of Proteus for accurate, high throughput measurements of Ca isotopes in bodily fluids to detect changes in bone mineral balance, indicative of diseases such as osteoporosis and kidney malfunction. We will work together with a spin-off company, osteolabs GmbH, who lead work in this new market, to produce a compelling case to be presented to Thermo Scientific Vertical marketing, the critical step to commercialisation.

Keywords: mass spectrometry,collision cell,isotope ratio measurement,bone mineral balance,medical diagnosis
Blockchain Protocol for Responsible Mineral Sourcing (MINESPIDER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany,Ireland,Switzerland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-05-01
End date: 2023-04-30
Duration (months): 36.0
Total project cost (EUR): 3294637.5
EU funding (EUR): 2306246.25
Participants: 4
Project status: SIGNED

Founded in 2018, Minespider is an open blockchain protocol and DApp for creating digital certificates to track minerals along global supply chains. Minespider provides the “Internet for the circulation of due diligence data packets” Minespider has built strong brand equity and mindshare, being recognised by key players in global supply chains, strong media presence, plus relationships with leading industry and development groups such as the Responsible Minerals Initiative. Built upon blockchain principles, we offer all stakeholders in the chain the opportunity to introduce and track the origins of the materials extracted, regardless of their transformation along the manufacturing process to create transparent and non-corruptible value chains and a trusted environment without the need for any middlemen. Our protocol is innovative, public, free and decentralized - designed to transform the entire raw materials industry so that information on its sustainability becomes transparent and a commodity. The Minespider Protocol is comprised of three key elements: 1. The Blockchain Layer: Decentralized, so that no single entity controls supply chain data. 2. The Application Layer: Enterprise software that grants access to the protocol. 3. The SILQ utility token: Allows the system to function without centralized control. This innovation is the central part of our strategy and is highly disruptive. Our mission is to establish the Minespider Infrastructure as the best practice in terms of responsible mineral sourcing and value chain tracking for all stakeholders - upstream, downstream and worldwide. Ultimately, our innovation drives our overall strategy to unify and standardize international efforts to address conflict minerals.

Keywords: tracking minerals,conflict minerals,responsible sourcing,corporate social responsibility,blockchain,non corruptible value chains and a trusted environment,raw materials,sustainability