Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding the influence of human and organizational factors on surgeon performance to enhance patient outcomes: experimental evaluation of a customized coaching program (TopSurgeons)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2025-01-31
Duration (months): 72.0
Total project cost (EUR): 1499818.0
EU funding (EUR): 1499818.0
Participants: 2
Project status: SIGNED

Individual performance of surgeon is a core element of successful surgery that can vary greatly over career for poorly understood reasons. Solutions to optimize physical and mental condition of surgeon during operation have not been thoroughly explored so far, while this may represent basic foundation for delivering high quality surgery. This surgeon-centred outcome research pursues three successive goals: 1-Identifying the key determinants related to surgeon's human factor and operating room organization influencing his/her performance in terms of patient safety and care efficiency; 2-Developing a customized coaching program for surgeons based on the human and organizational factors previously discovered, which includes a charting system for individual parameters and surgical outcomes feedback, profiling of individual surgeon, and standardized modules of improvement; 3-Implementing and measuring the impact of this program on surgical outcomes of a randomized group of surgeons against a control group of non-exposed surgeons. Inspired from previous experiences in the aeronautic and sport arena to improve pilots and athletes performance, our approach will take place in real time at the point of care in close collaboration with front-line personnel. A particular attention will be paid to quantify the influence of several factors that may affect how the surgeon operates every day (physiological stress, sleep quality, physical activities, workload, team composition and unplanned events in operating room). Generated knowledge on these factors will be exploited for identifying deficiencies that, if corrected, could improve surgeon's functional capacity. Solutions to control these factors and achieve optimal outcomes will then be experimentally tested to establish evidence-based standards of surgical practice. Those standards will be adapted to each surgeon's needs and preferences, potentially leading to a certification model for surgeons complying with excellence criteria.

Keywords: surgery,patient safety,performance
The first bioactive wound dressing - exploiting the unique wound healing and antimicrobial properties of human collagen VI (WOUNDCOM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 3592250.0
EU funding (EUR): 2514575.0
Participants: 1
Project status: SUSPENDED

Chronic wounds are a global problem. They severely impair the quality of life for 200 million patients worldwide and generate vast medical costs. It is a problem that will only escalate with the increasing incidence of conditions that impede wound healing, such as diabetes, obesity and vascular disorders. The available wound care options can manipulate one or multiple aspects of the wound environment but cannot form antibacterial barriers and facilitate healing to a satisfactory level at the same time. Effective wound care products to address both: rapid wound closure and combat of infection are, therefore, urgently needed. Colzyx aims to address the unmet challenges in wound management with its novel wound dressing. Basing on a ground-breaking discovery of wound healing and antimicrobial properties of human collagen VI and parts thereof, Colzyx has developed a product that has the potential to revolutionise wound management and create a new category of bioactive wound dressings. WOUNDCOM uses highly functional molecules that promote wound healing by mimicking natural body mechanisms and at the same time combat bacterial infection. This approach offers significant benefits to patients through reduction of pain and discomfort and accelerated recovery. It will also shorten hospitalisation time and decrease the associated financial burden. This project’s objective is to validate the efficacy and safety of WOUNDCOM and bring it to commercial readiness. The project builds on our SMEi Phase 1 project, which provided a valuable understanding of the current trends and opportunities on the wound management market, targeted users, competitors and potential partnerships. The feasibility study was used to optimise the business plan and prepare a synopsis for the clinical study. Successful evaluation of WOUNDCOM’s in the clinic will enable CE marking and support building the awareness and continued strategic partnerships for product manufacturing, marketing, and distribution.

Keywords: wound dressing,human collagen vi,biomembranes
Smart monitoring solution for better procurement and supply chain management - Speeding up chemical industry digitalization (TankSensor)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 2539002.5
EU funding (EUR): 1777301.75
Participants: 1
Project status: CLOSED

The global chemical industry is witnessing rapid changes in demand and leveraging digitalization to improve its operational efficiency has now become a vital need for the industry. Logistics is a key aspect of the chemical industry as production and consumption locations are mostly separated. Managing the supply chain has always been a major problem for the chemical industry. Companies work on tight margins and need constant monitoring of fill-level to ensure on-time product delivery and safety. The optimization of the logistics is the key factor which could differentiate one company from the other. However,chemical companies are stuck with the archaic fill level tank monitoring that blocks supply chain optimization and automation. To overcome the specific challenges, Nanolike created TankSensor,an IoT nanosensor and software solution for fill-level monitoring of industrial tanks. It creates network of the connected smart tanks, providing fill level and geolocation information remotely and in real time, enabling to plan, manage and optimise the supply chain. TankSensor is a non-invasive, easy to install Plug and Play device. It works for liquids,solids, gases and dangerous chemicals. It enables total visibility & control of chemicals fill levels improving stock management and eliminating risk of unexpected running out of stock. Our key customers are industrial sites, chemical suppliers and container manufacturers. The TankSensor uses our breakthrough, proprietary strain nanosensor to continuously monitor the fill-level of any container. It has been validated in tests with industrial chemical suppliers and has generated their strong interest. The project is well aligned with what we have done so far on nanosensor market, providing opportunity to scale-up our sales by reaching new market segments and increasing production volumes. The support from the EC will give us necessary resources to deploy the action plan and additional networking and business opportunities

Keywords: chemicals,chemical engineering,technical chemistry,transport,nanotechnology,nanosensor strain gauge,intermediate bulk containers
Chemistry of Sponge Microbiomes (COSMos)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

Molecules made by nature, or natural products, inspire the majority of currently approved small molecules for use in medicine. With an increase in widespread antibiotic resistance and the perpetual search for anticancer drugs, new sources of natural products must be discovered. The marine environment is a proven, prolific source of novel bioactive molecules and much of the ocean remains chemically and genetically unexplored. The mesophotic zone is particularly neglected because of the technological difficulty of reaching this twilight zone of the ocean. Shallow water marine sponges have been well documented to have diverse microbial populations and impressive chemical repertoires. Mesophotic sponges, however, are relatively unstudied in terms of their natural product potential. This project aims to take a deep dive into the metagenomes of mesophotic sponges for their natural product potential. Hybrid sequencing and assembly of metagenomes of eight prioritized sponges will uncover new biosynthetic gene clusters for heterologous expression and chemical elucidation. This study will combine large data analyses, cutting edge molecular and synthetic biology approaches and bioinformatic techniques to survey the natural product potential of mesophotic sponges and discover new molecules with medicinal potential.

Keywords: natural products,drug discovery,bioprospecting,heterologous expression,biosynthesis
Enhancing Innovation Management Capacities and Key Account Management (KAM) services for Greek SMEs (Enhancement SGA4)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Greece,Greece,Greece,Greece,Greece,Greece,Greece,Greece
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 231350.0
EU funding (EUR): 231350.0
Participants: 12
Project status: CLOSED

Innovation is key to boost productivity and has a role to play in the economic success of the era of new technologies (The Global Competitiveness Report 2018, WEF), while digitisation offers SMEs new opportunities to take part in the next production revolution (OECD SME and Entrepreneurship Outlook 2019). However, SMEs can lag behind in innovation capacity and innovation management capacity skills compared to large companies. Enterprise Europe Network-Hellas consists of 12 major business support organisations - key innovation players, industrial associations and innovation support organisations, as well as chambers of commerce and industry - creating a country-wide network. This network serves as a key facilitator in enhancing the competitiveness, innovation capacity and growth potential of Greek SMEs. The overall goal of the proposed action is to enhance the innovation capacities of Greek SMEs with international ambitions enabling their business growth and boosting their competitiveness in the Single Market and beyond. More specifically, the proposed action aims to: • Assist SMEs in identifying and addressing innovation management gaps and developing respective strategies; • Support SMEs to utilize the opportunities offered under the EIC Pilot Schemes -SME Instrument(SMEI), Fast Track to Innovation (FTI) and Future and Emerging Technologies (FET Open) programmes- as a tool for bridging the gap between research, innovation and market; • Identify SMEs with the capacity to innovate and internationalise and provide them with tailored services; • Offer targeted assistance on innovation management that, compared to large companies, have limited capacity for R&D activities and consulting services; • Support business innovators to translate their ideas into market success, fostering their innovation potential; • Empower SMEs to unlock their growth potential by better managing more effectively and efficiently their innovation processes.

Keywords: innovation,innovation management,sme instrument,fast track to innovation,fet open
Ultrasonic standing waves as a new tool for improved oleogels (ULTRA-OLEO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 202680.96
EU funding (EUR): 202680.96
Participants: 1
Project status: CLOSED

Oleogels are lipid-based materials that contain 85–99.5% of liquid oil whereas the rest is structuring molecules called oleogelators. They were introduced as saturated and hydrogenated fat substitutes to fight the adverse effects of excessive fat consumption in the diet such as obesity. Obesity is a global problem that nowadays involves billion of adults and millions of children. The annual healthcare costs related to treating diseases caused by/related to obesity is 60 billion euro in Europe and 210 billion dollars in USA. Oleogels can be used to reduce obesity outbreaks by substituting saturated fats. Unfortunately, oleogel storage instability impedes these materials from becoming the “fat of the future”. Much effort has been directed to explore strategies to improve oleogel performance such as formulation and processing. The proposed strategies are not able to precisely control the forming crystal network and can also lead to oxidized oleogels. To obtain oleogels with long storage stability it is necessary to carefully control the forming crystalline network without inducing adverse effects such as oxidation. To this aim, I will develop a new, economic, and environmentally friendly technology that can modify the structure of oleogels to prolong oleogel storage stability, bringing together food science, acoustic physics and engineering. To create such a technology, three goals are set: (i) develop a treatment chamber, (ii) optimize treatment of monoglyceride-containing oleogel, (iii) optimize treatment of wax-containing and phytosterol-containing oleogels. To identify the effect of the treatments, nano and microstructure, oil retention ability, and oxidation mechanisms are studied during and soon after the treatment, and during storage. The outcome of this proposal is a technology that can finely and precisely direct the crystallization process orienting lipid crystals in controllable shapes/patterns with the final aim to prolong oleogel storage stability.

Keywords: oleogel,ultrasound,stability,nanostructure,microstructure,oil release,oxidation
Networking and Care: Helping young people with mental health problems through outreach and eHealth (NCore)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-10-01
End date: 2019-03-31
Duration (months): 18.0
Total project cost (EUR): 149973.0
EU funding (EUR): 149973.0
Participants: 1
Project status: CLOSED

The aim of this project is to develop a mobile app which facilitates access to mental health services and treatments for young people with mental health problems; and to assess its feasibility, acceptability and potential clinical and cost-effectiveness. If successful, the app would: (1) increase access to mental health care by providing links to relevant existing services; (2) increase access to relevant evidence-based mobile health interventions and to address barriers to care and (3) allow individuals to review services they have used and provide feedback which can be accessed by other app users. Insufficient awareness of available services and treatments and how to access them, and the stigma associated with using treatment, are two of the most significant barriers to mental health care for young people. As part of the ongoing ERC APPLAUSE project, we have already collected data from a prospective community cohort of young people and found that among those with mental health problems, 40% wanted help but were not aware of how to get it. Thus, despite perceived need, many young people fail to find support. The ERC APPLAUSE project cohort provides us with a unique opportunity to understand how and whether the app can change service use patterns. We will randomise cohort participants with mental health problems to intervention and control conditions in order to understand changes in service use in addition to estimating short- and long-term economic impacts associated with the app intervention. Treatment can enormously improve outcomes for young people with mental health problems. Mental health problems experienced by young people can have many and often serious adverse effects, both early on and across the life-course. This app could help improve access to intervention and support, and hence alter developmental trajectories in a way that could improve the lives of these individuals and generate immediate as well as longer-term societal and economic benefits.

Keywords: mental health,young people,mhealth,economics,access to care,health services
The Role of OSTα/β as a Bile Acid and Drug Transporter in Obesity-Associated Chronic Liver Disease, Nonalcoholic Fatty Liver Disease (OSTtrans)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2021-03-03
Duration (months): 24.0
Total project cost (EUR): 179325.6
EU funding (EUR): 179325.6
Participants: 1
Project status: CLOSED

Obesity is increasing rapidly in EU, with about 50% of the population being obese. In addition to cardiovascular disease and type-2 diabetes, non-alcoholic fatty liver disease fatty liver disease (NAFLD) is a major obesity-associated chronic disease. Despite the high frequency of NAFLD, comprehensive research on its effects on hepatic biotransformation capacity is lacking, especially in human subjects. This project will use human liver tissues, human hepatocytes, organic solute transporter α/β (OSTα/β) over-expressing human cells and membrane vesicles, to evaluate the role of OSTα/β and other bile acid transporters in NAFLD, addressing a key question in current biomedical research: Can obesity lead to altered hepatic biotransformation and modulate the efficacy and safety of medications? The main objective is to elucidate the role of OSTα/β as a bile acid and drug transporter particularly in NAFLD. The hepatic expression of OSTα/β is normally low but dramatically increased in cholestatic conditions, even more than expression of other bile acid transporters. The project will focus on the proteomics of bile acid transporters and bile acid metabolome in NAFLD and NASH liver, regulation and mechanisms of OSTα/β transport, and the role of OSTα/β as a bile acid and drug transporter in the human liver. The project is strongly interdisciplinary, involving a combination of biochemistry, molecular biology, and analytical chemistry. The results will increase the understanding of NAFLD disease mechanisms, thus benefitting clinicians and authorities to ensure safe and effective drug therapies for the NAFLD population. This project examines one of the key priorities of European Commission, chronic diseases. In addition, the Applicant enhances her competences and the host widens its networks, thus supporting mutual knowledge transfer.

Keywords: basolateral transport,bile acid,cholestasis,drug induced liver injury,dili,nash,nonalcoholic fatty liver disease,liver,transporter,hepatocyte,pharmacokinetics,pharmacogenetics,slc51
Decreasing fuel consumption in transport (NANOL4TP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Finland
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The demand for high-performance lubricant additives is strongly driven by new regulations pushing for improved fuel efficiency and better consideration of the health, safety and environmental factors. Nanol Technologies Oy is a Finnish SME with a mission to provide solutions that enable reduction of fuel and oil consumption and extension of the lifetime of key engine and machine components. We think that our patented Nanol lubricant additive with strong scientific background will become a key technology in the 70 – 90 B€ global lubricants product market. The customer value of Nanol is based on superior cost-performance properties. Nanol improves engine performance with low technical risk, good compatibility with different engines and oils and thus offers very significant immediate savings without investment by the customer. Nanol has been used for 180 000 hours in marine engines and customers have reported consistent fuel savings. The SME Phase 1 project will focus on transport sector with the main objective to conceive comprehensive business plan with a strong go-to market strategy to facilitate the market expansion to high-volume markets.

Keywords: lubricant oil additives,anti wear,anti friction