Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Assessment of Zoan products as biomaterials for 3D printing in health care (InnovationOrigin)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Ireland
Call: European SME innovation Associate - pilot (H2020-INNOSUP-2019-02, 2019)
Start date: 2019-12-23
End date: 2022-08-22
Duration (months): 32.0
Total project cost (EUR): 114687.5
EU funding (EUR): 114687.5
Participants: 1
Project status: CLOSED

Zoan BioMed is a dynamic SME based in the West coast of Ireland. Zoan has turned to nature, specifically the Ocean, for the blueprints to solve a major biomedical challenge. Zoan specialises in cultivating medical-grade marine coral and creating products from it that can be used as an Orthobiologic scaffold, for use as a bone graft substitute. With the development of the InnovationOrigin Project, Zoan seeks to adapt and develop platform products as a material for use in 3D printers, to open up a new realm of potential applications for our products and in doing so create a significant market demand in new value chains. The development of 3D printing is now an exciting reality which provides enhanced career growth opportunities for each new generation of engineers and manufacturers entering the workforce. Furthermore, 3D printing technology is a rapid emerging technology which empowers manufacturers in the medical sector to produce customised medical equipment and products. If the project is successful, Zoan will be then in a position to enter the global 3D printing market which was valued at $4.2 billion in 2014, and is projected to reach $44.4 billion by 2025, registering a CAGR of 21.8% from 2019 to 2025. The Innovation Associate will act as a catalyst, driving our innovation strategy in 3D printing forward and aligning with our business targets of growing capacity on site, building a vibrant hub of employment in a remote part of Connemara and bringing the biomimetic potential of our bio-material to a number of sectors. Zoan will provide to the Innovation Associate with the opportunity to co-create their own future by helping to develop a new dimension to our business which they can champion and drive forward through defining new innovation projects and partnerships, making them an integral part of our team and providing them with a rewarding career in our company.

Keywords: 3d printing,additive manufacturing,biomaterial,health sector
European network of Cybersecurity centres and competence Hub for innovation and Operations (ECHO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Italy,Ukraine,Estonia,Ireland,Spain,Italy,Italy,Italy,Germany,Italy,Bulgaria,Finland,Hungary,Poland,Romania,Belgium,Belgium,Greece,Belgium,France,Netherlands,Netherlands,United Kingdom,Portugal
Call: Establishing and operating a pilot for a Cybersecurity Competence Network to develop and implement a common Cybersecurity Research & Innovation Roadmap (H2020-SU-ICT-2018-2, 2018)
Start date: 2019-02-01
End date: 2023-02-28
Duration (months): 49.0
Total project cost (EUR): 15987285.0
EU funding (EUR): 15987285.0
Participants: 42
Project status: SIGNED

ECHO delivers an organized and coordinated approach to improve proactive cyber defence of the European Union, through effective and efficient multi-sector collaboration. The Partners will execute on a 48-month work plan to develop, model and demonstrate a network of cyber research and competence centres, with a central competence at the hub. The Central Competence Hub serves as the focal point for the ECHO Multi-sector Assessment Framework enabling multi-sector dependencies management, provision of an ECHO Early Warning System, an ECHO Federation of Cyber Ranges and management of an expanding collection of Partner Engagements. The ECHO Multi-sector Assessment Framework refers to the analysis of challenges and opportunities derived from sector specific use cases, transversal cybersecurity needs analysis and development of inter-sector Technology Roadmaps involving horizontal cybersecurity disciplines. The Early Warning System, Federation of Cyber Ranges and Inter-sector Technology Roadmaps will then be subject of Demonstration Cases incorporating relevant involvement of inter-dependent industrial sectors. The ECHO Cyber-skills Framework provides the foundation for development of cybersecurity education and training programmes including a common definition of transversal and inter-sector skills and qualifications needed by cybersecurity practitioners. The ECHO Cybersecurity Certification Scheme provides a sector specific and inter-sector process for cybersecurity certification testing of new technologies and products resulting from the proposed technology roadmaps. The project will develop and operate under an ECHO Governance Model, by which the efforts across the EU Network of Cybersecurity Competence Centres can be coordinated and optimized to provide lasting and sustainable excellence in cybersecurity skills development; research and experimentation; technology roadmaps delivery; and certified security products for improved cybersecurity resilience.

Keywords: network of cybersecurity centres,early warning systems,federated cyber range,cybersecurity demonstration cases,cyberskills frameworks,education and training,security certification schemes
Research and Innovation Centre on Advanced Industrial Production (RICAIP)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Germany,Czechia,Czechia
Call: Teaming Phase 2 (H2020-WIDESPREAD-2018-01, 2018)
Start date: 2019-09-01
End date: 2026-02-28
Duration (months): 78.0
Total project cost (EUR): 14986215.0
EU funding (EUR): 14986215.0
Participants: 4
Project status: SIGNED

The Research and Innovation Centre on Advanced Industrial Production (RICAIP) unlocks the research and innovation capacity of CIIRC CTU and CEITEC BUT, by establishing a strong partnership with prominent German research organizations: DFKI and ZeMA, who jointly contribute to RICAIP by making their core facilities available and enable RICAIP to operate in a distributed way. RICAIP will be established at CIIRC CTU as an international centre operating fully in English. RICAIP will significantly contribute to upgrading the Institute from the national Centre of Excellence (CoE) in areas of informatics, robotics, and cybernetics to the European CoE of artificial intelligence and industrial robotics for advanced industry. For this purpose, RICAIP will build and develop the very first distributed testbed for advanced industrial production (RICAIP Industrial Testbed Core), that serves both academia and companies. The RICAIP Industrial Testbed Core will be established by integration of three local core facilities – the Prague testbed at CIIRC CTU, the Brno testbed at CEITEC BUT (both significantly upgraded by RICAIP), and the existing Saarbrücken Testbed – the joint facility of DFKI and ZeMA. RICAIP represents an international platform for Industry 4.0 scientific challenges as well as addressing current needs, gaps and demands of the industrial sector and society. RICAIP is a trigger for a significant upgrade of the academic and scientific environment. It promotes structural change and strikes against stereotypes and lack of innovative approaches. RICAIP benefits from its prominent governmental support and from traditionally strong industrial ties between Czech and German application sectors. The autonomy of RICAIP is supervised and guaranteed by the external Supervisory body of its stakeholders. The special status of RICAIP implying financial and organisational autonomy within the University is already internally formalised.

Keywords: industry 4 0,multi site industrial production,industrial testbed core,robotics,artificial intelligence,computer science,machine learning and perception,industrial automation and control
Temperature Regulation Of Prions In Crops (TROPIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

Temperature is a key environmental variable influencing plant distribution. Plants have colonised most habitats, from the tropics to the arctic circle. How plants are able to adapt to climate is of fundamental interest and of particular relevance during a period of rapid climate change, where plants have already been seen to change their phenology and range. Despite much interest in this area, understanding has been limited by our lack of knowledge of the mechanisms underlying temperature perception in plants. Recently, the host lab for this proposal has shown that proteins containing prion-domains (PrD) are able to function as thermosensors by undergoing temperature dependent phase-change. In unpublished work, the group has found that Heat Shock Factors (HSFs), which are essential for the induction of the protective heat shock proteins, are also controlled by PrDs and undergo phase change. These molecular sensing mechanisms by HSFs provide a unique opportunity to investigate how variation in the PrDs may “tune” the temperature response such that plants may adapt their HSFs to have a response at a threshold appropriate for their climate. E.g. rice grows robustly under temperature conditions that represent a lethal heatshock for Arabidopsis. In this proposal, I shall combine my expertise in studying rice environmental sensing from my PhD studies with recent developments in the Wigge laboratory in studying phase change of the HSFs in response to heat. I will use a comparative biology approach to determine the temperature response set-points of HSFs in vitro from a range of plants that grow under very different temperature regimes, and relate the behaviour of the PrD domains of the HSFs to the biological response of the plants to temperature. Finally, I will directly test my hypothesis by making directed changes to the thermosensory PrDs to increase and decrease thermal responsiveness, and assay these new thermosensors directly in plants and in a yeast system.

Keywords: thermosensor,prion,evolution,rice
LET'S GO FOR WATERBORNE TRANSPORT RESEARCH - BROADENING ENGAGEMENT AND INCREASING IMPACT (LASTING)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Spain,Austria,Belgium,Netherlands,Netherlands
Call: Improving impact and broadening stakeholder engagement in support of transport research and innovation (H2020-MG-2020-SingleStage-INEA, 2020)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 1288456.25
EU funding (EUR): 1288456.25
Participants: 7
Project status: SIGNED

Considering the diversity of the waterborne transport sector, its geographical scope, the international dimension and the challenges and opportunities upfront, LASTING will broaden engagement of the broader waterborne transport sector in European RD&I activities, by developing a communication strategy, and implementing a long-lasting communication campaign beyond the lifetime of this project, ultimately increasing, stakeholder engagement in the sector and thereby increasing impact of European waterborne transport RD&I. The communication strategy, and thereby the campaign will be based on clear KPI’s set at the starting point of LASTING, jointly developed with the relevant European Commission Services and the broader waterborne transport sector. The achievement of the KPI’s will be measured at fixed intervals, to ensure that the final communication strategy and the campaign will be fit-for-purpose and ready for roll-out. An essential element of the communication strategy will be the development of a plug-and-play system for participation in European, national or regional strategic maritime and/or inland waterway transport events. In the framework of LASTING, the plug-and-play system will be tested at a number of occasions, to ensure the system is fit-for-purpose. In addition, high quality dissemination materials (such as flyers and banners) and templates will be delivered. There will be a main focus on the use of digital tools for dissemination purposes, to ensure that the communication efforts of the waterborne transport community will easily follow the concept launched in the framework of LASTING. Finally, yet importantly, the Waterborne TP will take over the communication strategy and campaign after the lifetime of LASTING and will ensure a durable implementation of the concepts and materials developed in the framework of the project.

Keywords: waterborne,transport,communication,research,development and innovation
MAKing Sustainable development and WELL-being frameworks work for policy analysis (MAKSWELL)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Coordination and support actions
Countries involved: Germany,Italy,Germany,Italy,Hungary,Netherlands,United Kingdom
Call: Towards a new growth strategy in Europe - Improved economic and social measurement, data and official statistics (H2020-SC6-CO-CREATION-2017, 2017)
Start date: 2017-11-01
End date: 2020-10-31
Duration (months): 36.0
Total project cost (EUR): 934296.88
EU funding (EUR): 934296.88
Participants: 8
Project status: CLOSED

MAKSWELL project proposes to extend and harmonising the indicators able to capture the main characteristics of the beyond-GDP approach proposing a new framework that includes them in the evaluation of the public policies. The main goals of the project can be summarized in three main objectives. In particular, the project aims at: 1_building up a database for a wide set of EU countries that select and harmonize the national framework on well-being as well as the available SDG indicators; 2_improving the Database both in relation to the timeliness and to the integration with big data measures and the methodologies able to reach these extensions. Particularly WP2 will extend the actual set of information available on well-being and sustainability to including coherent new data sources (eg big data) able to derive coherent indicators for local analysis and disaggregation for other domain; 3_using the extended Database for policy evaluation and built up a national pilot studies. MAKSWELL project aims at creating a shared knowledge on the state of the art on relevant dimensions of sustainable development and on vulnerabilities and potentialities of society; on the most appropriate traditional and new data collection tools and modern statistical methods to have timely and accurate data. The analysis and summary of the main features of the piloting process will produce recommendations. They will be substantially suggestions and best practices collections to maintain and update the prototype fed by these new and traditional data sources for more focused policy decisions. The knowledge will be built up through the contact and reciprocal fertilization of NSIs, academics and stakeholders, identifying and contacting key practitioners to participate in a virtual Working Group. projects results will also path ways for common research under FP9.

Keywords: beyond gdp,sdg indicators,evidence based decision making practices,micro macro approach,big data,small area estimation,data integration,local analysis,multivariate time series models
The genomic basis of convergent evolution in modern sloths (Xenarthra, Mammalia) (CONVGENOMS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

At the end of the Pleistocene mass extinctions of the mega-fauna occurred worldwide, in particular in the Americas. Following the last glacial period, mammoths, mastodonts, giant sloths and other large mammals succumbed until extinction (about 10,000 years ago). While some Orders within Mammalia lost a couple of species, the sloths (Folivora, Xenarthra) clade has virtually lost all its diversity, gaining a status of a nearly-extinct suborder. Only two out of the close to 100 genera estimated to have existed survived to the mass extinctions to this date, named Bradypus and Choloepus. In contrast to their giant relatives, the modern sloths are medium-sized animals that developed a very specialized feature: obligatory arboreal suspensory behaviour. Their surprisingly high number of superficial similarities were acquired in parallel – since both genera are completely unrelated, and probably diverged ~30 Mya – and represent an amazing example of convergent evolution. In the current Genomics era, we are finally at a point in which full genomes can be assembled for non-model organisms at reasonable costs, bringing unprecedented opportunities for new studies on elementary questions on evolution. Here we propose to study the genomic signs of convergent evolution leading to obligatory suspensory locomotion and low metabolic rate on a comparative genomic analysis including 4 whole genome sloth sequences, three of which will be sequenced and assembled within this study. The Experienced Researcher masters all the bioinformatics expertise to complete the genomes. The host institution offers all the infrastructure and hypothesis thinking to successfully finalize the project. Jointly this team can push the boundaries of biological knowledge beyond, which will help the applicant to mature in order to lead a research group in the future. The applicant will also be trained in project management, supervision, teaching, and presentation of scientific results.

Keywords: convergent evolution,mammalian evolution,comparative genomics,whole genome sequencing,molecular evolution
Investigating the interplay between VWF, platelets, and neutrophil extracellular traps in pathologies involving thrombosis of the microvasculature (VWF and NETs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-03
End date: 2019-10-02
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

Thrombosis is a complex process involving activation of endothelial cells, and their release of Weibel-Palade body contents such as von Willebrand factor (VWF) and P-selectin. This in turn recruits platelets which form aggregates, and leukocytes such as neutrophils. The recent discovery of neutrophil extracellular traps (NETs) described a novel antimicrobial function of neutrophils. NETs are extracellular chromatin strands containing microbicidal proteins. The release of histones, serine proteases, and myeloperoxidase concentrated on DNA fibers into the extracellular space can contribute to many pathologies. NETs can bind platelets and red blood cells and therefore also contribute to thrombosis. Activated platelets can in turn stimulate neutrophils to make NETs, creating a vicious thrombo-inflammatory cycle. Our first objective is to study VWF involvement in the induction of NETosis. We will elucidate the role of VWF as an important mediator of NET formation using VWF mutants. Innovative live-cell imaging and flow cytometry will be used to unravel the kinetics of VWF/platelet-mediated NET formation. Our second objective is to assess the physiological relevance of (inhibiting) platelet/VWF involvement in NETs-related pathology. We will investigate the role of VWF/NET interactions in three critical clinical settings where microvascular thrombosis contributes to multiorgan failure and/or mortality: sudden inflammatory response syndrome (SIRS), thrombotic thrombocytopenic purpura (TTP), and severe malaria. Mouse models of disease will be used and combined with several strategies for inhibition of VWF/platelet/NETs interactions to assess their effect on disease progression. In summary, with this research project we aim to better understand how platelets and VWF can drive NET formation in thrombo-inflammation, as this may also lead to more targeted therapeutic approaches in diseases which currently have limited treatment options.

Keywords: thrombosis
For cognitively-impaired or visually-impaired persons suffering from spatial disorientation, a smartphone-based navigation aid that is both reliable and safe for urban pedestrian mobility. (ANGEO2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: France
Call: SME Instrument (H2020-SMEINST-2-2015, 2015)
Start date: 2015-10-01
End date: 2017-08-31
Duration (months): 23.0
Total project cost (EUR): 998670.0
EU funding (EUR): 699069.0
Participants: 1
Project status: CLOSED

The objective of ANGEO2 is to develop an orientation aid that is both adapted and directly useful for persons suffering from spatial disorientation, whether they be cognitively-impaired or visually-impaired persons. The product will provide easy access to urban areas and include multimodal guidance functions mixing walking with real time bus, tram and metro public transportation information. ANGEO2 is an incremental innovation in the niche market of urban mobility for sufferers of visually-disorientation, epilepsy, Parkinson's and Huntington. Reliable information is the key to reassuring the user and therefore providing autonomous mobility. The need for these devices is getting stronger everyday, however the market for orientation aids has not yet taken off. Why is this? The reason is that the services offered up to now are simply not reliable enough in terms of continuous service availability and accurate guidance. The unique selling proposition of ANGEO2 is the full availability of reliable navigation information in difficult urban environments. A summary of the different types of product and service offerings from the business model is shown below: • ANGEO-Mobile kits running without a smartphone • ANGEO-Pos high performance positioning modules linked to a smartphone • ANGEO-Nav, freemium navigation software running on a smartphone • ANGEO-Help, a payable helpline using an externalised, remote-assistance platform For a requested EU grant 713K€, an estimated 46 M€ of cumulated sales will create up to 80 jobs over a 5 year period. An open development platform for the European healthcare industry to create derivative offerings will also be made available.

Keywords: safe,reliable navigation aid using galileo,egnos and gps hybrid pedestrian navigation spatial disorientation visually impaired institute of vision