Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Insights into a Maritime World: Understanding Indian Ocean Trade through an Old Tamil Littoral Narrative (MariTamil)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

MARITAMIL seeks to unravel the economic and historical significance of Old Tamil literary sources composed in the ancient South Indian royal courts, which actively engaged in the Indo-Roman trade between the 1st and 4th centuries AD. This epoch marked a pivotal juncture in the region’s history, as evidenced by the rich literary heritage of the Old Tamil Caṅkam corpus, since the economic opportunities inherent in trade relations led to the emergence of ‘early kingdoms’ and triggered their economic rise. The project aims at preparing a new critical edition of the text called Paṭṭiṉappālai from the surviving manuscripts (palm-leaf and paper) accompanied by an exhaustive philological and historical analysis. This unique source provides a window into the life of Pukār, a port on the southern shores of India, where, according to the Tamil texts, Greek ships arrive laden with precious gold and depart carrying the coveted cargo of pepper. The goal is to rethink our conception of early Tamil history and maritime trade with the countries participating in Indian Ocean trade by bringing together sources kept apart and utilised by separate disciplines such as history of literature, history, and archaeology. A new annotated translation will introduce this text to the international research community engaged in Indo-Roman trade and highlight it as a crucial source text for analysing the Monsoon Asia region in antiquity.

Keywords: indo roman trade,monsoon asia,ca kam literature,tamil history,pa i app lai,south indian history,manuscript studies
Multiscale assessment of the amyloid assembly of MICRObiota-associated Bap proteins and the intermolecular templating of alpha-SYNuclein fibrils (MICROSYN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-04-01
End date: 2028-03-31
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

The global rise in Parkinson’s disease (PD) and other neurodegenerative disorders is becoming an important public health concern in the European Union and worldwide. Recent discoveries have revealed a direct connection between biofilm-associated proteins (Baps) from the human microbiota and alpha-synuclein (alpha-Syn) aggregation - a pathological hallmark of PD - supporting the hypothesis that the gastrointestinal tract plays a role in the pathogenesis of neurodegenerative diseases. The MICROSYN project aims to investigate the molecular mechanisms behind the impact of Bap proteins - BapSa from Staphylococcus aureus and Esp from Enterococcus faecalis - on the aberrant assembly of alpha-Syn. Currently, structural models of BapSa and Esp amyloid fibrils and the intermolecular interactions during the templating of alpha-Syn aggregation are unknown. Utilizing the state-of-the art techniques magic angle spinning solid-state nuclear magnetic resonance and atomic force microscopy, this project will provide atomic-level information on Bap and Esp amyloid fibril structure and dynamics, reveal conformational changes upon cross-seeding with alpha-Syn, and offer valuable insights into the fibril architectures at the mesoscopic scale. This will be achieved through the expertise of Dr. Álvarez-Mena in the biochemistry and molecular biology of bacterial amyloids, combined with the host lab know-how in solid-state NMR, AFM and complementary physico-chemical techniques, supported by the cutting-edge facilities of the host institution. Understanding the interaction between microbiota-derived BapSa/Esp and human alpha-Syn will offer new therapeutic avenues for combating PD, while insights into the structures of BapSa and Esp fibrils will aid in developing antimicrobial and antibiofilm agents to tackle antibiotic resistance. Thus, the MICROSYN project will support EU health priorities by fostering innovation in disease prevention and treatment.

Keywords: biofilm associated proteins amyloid fibrils cross seeding alpha synuclein microbiota neurodegeneration structural architecture solid state nmr atomic force microscopy
ADPribosylation and Ubiquitination; post-translational interplay (ADProbe)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1999625.0
EU funding (EUR): 1999625.0
Participants: 1
Project status: SIGNED

Post-translational modification of proteins is essential in regulating proper cellular homeostasis. The attachment and removal of the small protein Ubiquitin (Ub) is amongst others involved in regulating immune response, cell cycle progression and proteasome mediated protein degradation. The (de)conjugation of adenosine-di-phosphate ribose (ADPr) on the other hand is essential in regulating DNA damage responses and apoptosis. ADPribosylation and ubiquitination both dictate a highly complex signaling code and intriguingly these two PTM systems also communicate, as Ub was recently found to be ADPribosylated on multiple different positions. This new layer of controlling ubiquitination plays important roles in intracellular bacterial replication, DNA damage repair and tumor development. Understanding this fascinating post-translational interplay and the role the different UbADPr-isotypes play in cell biology is crucial to develop novel strategies for therapeutic intervention in diseases such as infection diseases and cancers. What are the mechanisms, biochemical scope of protein-protein interactions, cell biological consequences and differences between these non-studied UbADPr linkages? I propose to study the entire system of dynamic ADPribosylation of Ub and explain the molecular details of the (de)conjugating enzymes, explore the cell biological networks involved and exploit the key enzymes for inhibitor discovery en-route to future therapeutic intervention. I will develop novel chemical methodologies and create a set of new substrates, activity-based probes and assay reagents and use them to profile specificity and preferences of the involved enzymes, study the interactions and pathways in cells and screen for small molecule inhibitors. Using my expertise in protein synthesis and chemical- and structural biology I aim to unveil the details of this until now poorly studied, but crucial, hidden layer of post-translational interplay in an unbiased manner.

Keywords: ubiquitin,adpribosylation,protein synthesis,activity based probes,inhibitor discovery,proteomics,chemical synthesis,post translational modifications,profiling enzyme activity,structural details
Enhanced VAccines DEsign against antimicrobial REsistance (EVADERE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Ireland,United Kingdom,Spain,Germany,Hungary,Denmark,France,Romania,Korea, Republic of
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 4805921.67
EU funding (EUR): 4552724.16
Participants: 23
Project status: SIGNED

EVADERE (Enhanced VAccines DEsign against antimicrobial REsistance) is a multidisciplinary consortium of 14 interna-tionally recognised experts (12 from academia and 2 from industry) from 9 European countries who will provide 15 doctor-al candidates (DCs) with high-quality inter-sectoral training in discovery and development of vaccines targeting antimicro-bial resistance (AMR) based on innovative antigens, adjuvants, and delivery methods. Trainees will acquire a broad range of transferable skills to underpin their resilience for future careers in vaccine research within academia and industry respecting gender and equality.
Making Morality Impartial: An Experimental Investigation of the Veil of Ignorance (IMPARTIAL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria,Japan,United Kingdom,New Zealand
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-05
End date: 2028-07-04
Duration (months): 57.0
Total project cost (EUR): 271743.84
EU funding (EUR): 271743.84
Participants: 4
Project status: SIGNED

We are living in an age of increased moral disagreement and polarization. One explanation for this trend is partiality. People on one or both sides of contested social issue (abortion, COVID-19, climate change, etc.) do not give equal or adequate weight to the interests of all those concerned. Their views are based on bias or prejudice. Finding ways of increasing impartiality may therefore be one of the most important tasks that humanity currently faces. My project attempts to contribute to this task. In particular, I will investigate one particular device that philosophers have used to promote impartial reasoning, namely the so called “veil of ignorance” thought experiment — an attempt to abstract from knowledge about one’s gender, race, income and other morally irrelevant characteristics that might distort one’s judgments. Previous research has only focused on people’s actual choices behind the veil of ignorance. My project, in contrast, will investigate the methodological appropriateness of this thought experiment. (1) How robust is the VOI (i.e., to what extent are the judgments people arrive at by engaging in the thought experiment influenced by irrelevant factors)? (2) How effective is the VOI (i.e., to what extent does it fulfill the function it was supposed to fulfill)? (3) What are the larger philosophical implications of these findings? The framework that I will use in investigating these questions is that of experimental philosophy. That is, I will run empirical studies on people’s intuitions to inform philosophical argumentation. Being supervised by leading experts at the Universities of Tokyo (outgoing phase), Graz (return phase), Oxford (secondment) and Auckland (secondment), my research has the potential to significantly impact a number of debates in both philosophy and psychology — and hopefully, it can also make a small contribution to making morality more impartial in public discourse.
MONITORING AND DETECTION OF BIOTIC AND ABIOTIC POLLUTANTS BY ELECTRONIC, PLANTS AND MICROORGANISMS BASED SENSORS (Mobiles)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Greece,Italy,France,Spain,Poland,Israel,Cyprus,Serbia,Germany,Czechia
Call: Biosensors and user-friendly diagnostic tools for environmental services (HORIZON-CL6-2023-ZEROPOLLUTION-01, 2023)
Start date: 2024-09-01
End date: 2028-02-29
Duration (months): 42.0
Total project cost (EUR): 4644952.5
EU funding (EUR): 4644952.5
Participants: 16
Project status: SIGNED

Currently there are no portable test or biosensors validated for air, soil or water quality control for pathogens, Chemicals of Emerging Concern (CECs) and Persistent Mobile Chemicals (PMCs), so such devices are much awaited by all stakeholders to ensure successful control and prevention of contamination and infections. Mobiles consortium will develop an interdisciplinary framework of expertise, and tools for monitoring, detection, and consequently mitigation of pollution from pathogens, CECs, PMCs, thus benefiting human and environmental health. Mobiles consortium will work to achieve the following objectives: Develop electronic biosensors for monitoring organic chemicals (pesticides, hormones) and antimicrobial resistance bacteria and pathogens in water, soil and air; Develop organism-based biosensor for detection of organic and inorganic pollution in water and soil; Study environmental performance of developed organisms and devices; Metagenomics analysis of organisms leaving in polluted areas in order to enable searches for diverse functionalities across multiple gene clusters Perform safety tests (e.g., EFSA) to assess the impact of developed organisms on the natural environment. Organism-based biosensor will consist on genetically modified chemiluminescent bacteria able to detect antibiotics, heavy metals, and pesticides in water; genetically modified plants that will change colour when in the soil is present arsenic; and marine diatoms that will be used to detect bioplastic degradation in marine and aquatic environments. Developed devices and organisms will be implemented by using flexible technologies, which can guarantee an easy adaptation to other biotic and abiotic pollutants. Devices and organisms, after proper validation and approval, could be used by consumers, inspection services and industry operators, as well as environmental emergency responders to monitor and detect PMCs, CECs and pathogens in water, air and soil

Keywords: electrochemical biosensors,plants,bacteria,environmental risk,meta anlysis,dna rna sequencing,genetic modification,cecs,pmcs,antimicrobial resistance
REMORA - Small fishes in a big pond (REMORA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Social Sciences and Humanities
Countries involved: Portugal,France,Denmark,Ireland
Call: Pathways to Synergies (HORIZON-WIDERA-2023-ACCESS-04, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 1189403.75
EU funding (EUR): 1189403.75
Participants: 9
Project status: SIGNED

The growing innovation divide across the European Union appears particularly detrimental to small and emerging regional research and innovation systems like the Outermost Regions. With limited resources, these regions struggle to reach the critical mass needed to build comparative advantages and become knowledge societies. Though the European Research Area and the Framework programmes could compensate this marginalization through greater knowledge circulation, resources sharing and talents mobilities, the Outermost Regions present a limited participation in FP7 and Horizon 2020. This underutilization notably stems from the competing relations between structural funds (ESIF) and the framework programs or “substitution effect”: many organizations and individuals prioritize easily accessible ESIF, decide not to apply to the FP and end up in “substitution trap” which isolates them from promising collaborations. To move Outermost Regions’ R&I organizations and systems from substitution to synergies, REMORA ambitions to transform 3 Ocean and Marine ESIF-funded institutions in La Réunion, Madeira and the Azores into Horizon Europe champions : CITEB, OKEANOS and OOM. To that end, REMORA will enhance their competitiveness (notably human resources, knowledge transfer and innovation capacities), strategic positioning and connections with major EU networks through a joint internationalization strategy. REMORA will then use the successful transformation of these 3 role models to lead other ESIF-oriented R&I organizations and policy-makers in Outermost and Widening Regions on the path to synergies.

Keywords: synergies substitution outermost regions islands widening randi systems smart specialization strategy knowledge economy european research area framework programmes horizon europe
EIT Cross-KIC Shared Services (EIT_XKIC_ShS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Institute of Innovation and Technology (EIT)
Theme: other EIT
Destination: other EIT
Action type: Knowledge and Innovation Communities
Countries involved: Germany,Spain,Netherlands,Belgium,France,Finland,Sweden
Call: EIT Cross-KIC Shared Services (HORIZON-EIT-2023-2025-KIC, 2023)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 19026994.0
EU funding (EUR): 19026994.0
Participants: 18
Project status: SIGNED

The Shared Services Cross-KIC’s objective is to identify and create opportunities for KICs to achieve synergies across different common area of concern. EIT KICs by design have a specific status that requires them to adhere to requirements set by EIT and the EC in order to be eligible to receive funding. The Shared Services Cross-KIC tackles these requirements (largely specified in the Call document) through different activities: (1) CLC Consolidation to achieve efficiency and impact in building the required KICs’s presence in Europe while enabling facilitate collaborations; (2) Communicate and Disseminate the results of KICs activities and engage with the EU policy debate through EIT Community common events (InnovEIT, CLC Open days) as well as flagship premises to engage with specific ecosystems (EIT House Brussels, EIT Hub Budapest), and (3) comply to operational requirements with an efficient and common approach, such as joint procurement of Audits for CFS, verification on New Partners, and a common IT tooling to manage the EIT Grant and related reporting.
Pushing the limits of detection in spintronic sensors into the femtoTesla range (FemtoSense)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: CLOSED

Novel and compaImplementation of solid-state magnetic field sensors with ultra-high sensitivity and ultra-low magnetic-field detectivity is mandatory to accelerate the development of individualized and precision healthcare devices and promote the change to more energy efficient green technologies. Unlike other studies, the project will provide major advances in the field of spintronic tunneling magnetoresistance (TMR) sensors by pushing their limit of detectivity to the femtoTesla range without using external tools as magnetic flux concentrator, which is an artificial technique to increase sensitivity regardless to the origin of limitation in TMR multilayer structure as noise sources. For that, FEMTOSense is to pinpoint the origin and mechanisms that govern all noise contributions, and their control, on-demand, using materials science and device engineering. To do this, I will develop highly (001)-textured spinel oxide MgAl2O4 (MAO) tunneling barriers enabling tunable lattice matching with wide range of ferromagnetic electrodes particularly CoFeB, to suppress the interfacial imperfection (noise) at the interface and improve TMR ratio. I will also improve the quality of the ferromagnetic electrodes by development of functional sensing layers consisting of sandwich-like amorphous ferromagnet. The ferromagnetic sandwich comprises thin layers of super-soft NiFe inserted between amorphous phase of CoFeBTa ferromagnetic layers. The former is to prevent propagation of 111-texture of NiFe to MAO barrier, ensuring ordering interface with minimized electronic noises. The latter is to tune the structural and magnetic characteristics of the sensing layers, enabling high sensitivity and suppressing magnetic noise at the sensing layer. Finally, I will establish a framework to map all sources of noise within each of the spintronic sensor building blocks, and identify the method of treatment by theoretical modeling for demonstration of femtoTesla tunneling magnetoresistnce sensors.

Keywords: spintronics magnetism tunneling magnetoresistance sensors noise
FERTIliser product recovery from secondary raw materials using best available TEChniques (FERTITEC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Coordination and support actions
Countries involved: Sweden,Greece,Finland,Spain,Poland,Kenya
Call: Best available techniques to recover or recycle fertilising products from secondary raw materials (HORIZON-CL6-2024-ZEROPOLLUTION-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 2188395.17
EU funding (EUR): 1975338.98
Participants: 7
Project status: SIGNED

FERTITEC builds upon the knowledge gained from previous EU-funded projects, such as Novafert, FER-PLAY, MainstreamBIO, SOILUTIONS, SuMaNu, AgroTechnology ATLAS, B-FERST, NOVAFERT, CINURGI, Manure Standards, SUSFERT, NUTRI-KNOW, NUTRIMAN etc. which have explored the potential of waste management and nutrient recovery from various perspectives. By integrating the insights and technological advancements from these previous initiatives, FERTITEC is positioned to deliver a comprehensive solution for waste recycling and sustainable fertiliser production from secondary raw materials. The principal objectives of this group of related projects, that FERTITEC aligns with and supports, are to transform waste into high-quality fertilisers, promote a circular economy, and mitigate environmental impact, thereby aligning with the EU's goals of sustainable agriculture, waste reduction, and bioeconomy enhancement. FERTITEC is commited to develop competitive fertilisers that are not only benefit agricultural yield but also promote a circular economy model, aligning with the EU's strategic focus. This dual focus of environmental sustainability and economic viability resonates with the objectives of our previous projects, which aimed to boost the marketability of bio-based products and harmonise global sustainability certification systems respectively. By involving key actors from the agriculture sector and facilitating multi-stakeholder discussion through our KEP, FERTITEC fosters a community-driven approach to boost sustainable innovation in the fertiliser sector. We seek to make a tangible impact at national and regional levels, by deploying our best availalbe fertilising techniques in several EU countries, as well as extrapolationg our outcomes to the African Union landscape by providing practical recommendations and guidelines. Overall with FERTITEC we aim the adoption of our alternative fertilising products and the wider transformation of the agricultural sector globally.

Keywords: alternative fertilisers,recycling recovering fertilising products,best availalbe techniques,fertiliser industry,farmers,sustainable agriculture,best alternative fertilising products