Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Construction techniques, experimentation and innovative architectural solutions at Hadrian’s Villa (Tivoli, Italy) (Constr-HaVi)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

The aim of this Fellowship is to develop the professional prowess, advanced training, interdisciplinary skills, high-impact dissemination, and practical experience commensurate with a leading independent researcher in the EU. The aim of the project is to investigate the building and engineering techniques utilized in constructing Hadrian’s Villa. For the first time, I will apply a new research approach to a comprehensive study of the villa that concentrates not only on architectural design and form but also on building materials, construction techniques and engineering. The main objective is to create a synthesis combining analysis of the buildings with a critical study of the bibliography that will result in a comprehensive corpus of the building solutions found in the different structures across the entire site. I will be based in the Department of Classics in Trinity College Dublin (TCD), working under the supervision of Professor Hazel Dodge. Research training will be implemented through an interdisciplinary project investigating the ancient architectural process of construction. I will access expertise, advanced training and mentoring in the History of architecture. No Irish university, but Professor Dodge, has yet established a dedicated History of the roman architecture. In TCD I will be given the opportunity to embed new knowledge in the design of interdisciplinary curricula for graduate students. Under the guidance of international experts, I will acquire an invaluable skill-set bridging humanities, science and technology with implications for contemporary conservation of cultural heritage. The resources of the host departments will facilitate development of an interdisciplinary and international academic network as well as career-mentoring. The Fellowship will establish me firmly at the centre of interdisciplinary research in the histories of building science.

Keywords: archaeology of construction,hadrian s villa,ancient architecture,organization and use of space,building and engineering techniques of construction,experimentation,innovations,this proposal
Analysis, control, and engineering of spatiotemporal pattern formation (ACE-OF-SPACE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-07-01
End date: 2026-06-30
Duration (months): 72.0
Total project cost (EUR): 1997750.0
EU funding (EUR): 1499866.26
Participants: 2
Project status: SIGNED

A central problem in developmental biology is to understand how tissues are patterned in time and space - how do identical cells differentiate to form the adult body plan? Patterns often arise from prior asymmetries in developing embryos, but there is also increasing evidence for self-organizing mechanisms that can break the symmetry of an initially homogeneous cell population. These patterning processes are mediated by a small number of signaling molecules, including the TGF-β superfamily members BMP and Nodal. While we have begun to analyze how biophysical properties such as signal diffusion and stability contribute to axis formation and tissue allocation during vertebrate embryogenesis, three key questions remain. First, how does signaling cross-talk control robust patterning in developing tissues? Opposing sources of Nodal and BMP are sufficient to produce secondary zebrafish axes, but it is unclear how the signals interact to orchestrate this mysterious process. Second, how do signaling systems self-organize to pattern tissues in the absence of prior asymmetries? Recent evidence indicates that axis formation in mammalian embryos is independent of maternal and extra-embryonic tissues, but the mechanism underlying this self-organized patterning is unknown. Third, what are the minimal requirements to engineer synthetic self-organizing systems? Our theoretical analyses suggest that self-organizing reaction-diffusion systems are more common and robust than previously thought, but this has so far not been experimentally demonstrated. We will address these questions in zebrafish embryos, mouse embryonic stem cells, and bacterial colonies using a combination of quantitative imaging, optogenetics, mathematical modeling, and synthetic biology. In addition to providing insights into signaling and development, this high-risk/high-gain approach opens exciting new strategies for tissue engineering by providing asymmetric or temporally regulated signaling in organ precursors.

Keywords: embryonic development,signal transduction,zebrafish,systems biology,self organization
The European network for observing our changing planet (ERA-PLANET)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Developing comprehensive and sustained global environmental observation and information systems
Action type: ERA-NET Cofund
Partnership: ERA-PLANET (ERA-NET)
Countries involved: Germany,Estonia,Italy,Italy,Italy,Italy,Italy,Ukraine,Austria,Germany,Germany,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Italy,Italy,Switzerland,Finland,Greece,Sweden,Sweden,Switzerland,Greece,Greece,Romania,Slovenia,Sweden,France,France,France,France,France,France,France,France,France,France,Czechia,Denmark,Portugal
Call: Strengthening the European Research Area in the domain of Earth Observation (H2020-SC5-2015-one-stage, 2015)
Start date: 2016-02-01
End date: 2022-01-31
Duration (months): 72.0
Total project cost (EUR): 37323152.45
EU funding (EUR): 10962255.91
Participants: 59
Project status: CLOSED

In the last decade a significant number of projects and programmes in different domains of environmental monitoring and Earth observation have generated a substantial amount of data and knowledge on different aspects related to environmental quality and sustainability. Big data generated by in-situ or satellite platforms are being collected and archived with a plethora of systems and instruments making difficult the sharing of data and knowledge to stakeholders and policy makers for supporting key economic and societal sectors. The overarching goal of ERA-PLANET is to strengthen the European Research Area in the domain of Earth Observation in coherence with the European participation to Group on Earth Observation (GEO) and the Copernicus. The expected impact is to strengthen the European leadership within the forthcoming GEO 2015-2025 Work Plan. ERA-PLANET will reinforce the interface with user communities, whose needs the Global Earth Observation System of Systems (GEOSS) intends to address. It will provide more accurate, comprehensive and authoritative information to policy and decision-makers in key societal benefit areas, such as Smart cities and Resilient societies; Resource efficiency and Environmental management; Global changes and Environmental treaties; Polar areas and Natural resources. ERA-PLANET will provide advanced decision support tools and technologies aimed to better monitor our global environment and share the information and knowledge in different domain of Earth Observation.

Keywords: earth observation,geoss,copernicus
Protection Beyond Operating System - Development of the next generation cyber security solution (ProBOS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Malta,Netherlands
Call: Engaging SMEs in security research and development (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-10-01
End date: 2019-03-31
Duration (months): 30.0
Total project cost (EUR): 2814766.28
EU funding (EUR): 1970336.4
Participants: 2
Project status: CLOSED

Cybercrime is on the rise in terms of scope and impact, which is facilitated by current environment: increasing use of mobile devices, social networking, mobile communications and cloud computing. Cyber attacks are made mostly against governments and corporates to gather guarded information, or to disrupt their operation in general. Advanced attackers targeted 5 out of 6 large companies each month in 2014, whereas 60% of all targeted attacks struck small- and medium-sized organisations. The same year companies across all industries worldwide have reported a total of 42.8 million detected attacks. And the consequences are varied and serious: crime involving computers and networks has cost the world economy more than $445 billion annually and the cost is expected to reach 1 trillion in 2016. Restroring damages caused by successful cyber attacks is extremely difficult and costly, if not impossible. Moreover, when a security breach occurs, the company or organisation concerned not only loses valuable and/or sensitive data, but it also suffers damage to its brand and reputation that can take a lot of time and money to repair. The increasing cybercrime urges for innovative cyber security solutions that are able to detect and immediately respond to attacks that are highly sophisticated and damaging, which is more important than ever. And this phenomena generates market opportunity for cybersecurity specialty companies. At ReaQta we develop the next generation cyber security protection solution –ReaQta-core - that can revolutionise the IT security market by offering a higher level of protection to governments and private organisations. ReaQta-core is the first to apply a novel approach that incorporates a unique NanoOS and an Artificial Intelligence Engine to protect endpoints from the most advanced and sophisticated cyberthreats.

Keywords: cyber security,cyber attack,cyber crime,malware,ransomware,exfiltration,exploits,artificial,intelligence,nanoos,forensics,threat analysis,data protection,endpoint protection,disruptive
Multimodal preclinical imaging probes to evaluate the safety and efficacy of regenerative medicine therapies (MultimodalCellTrack)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-08-01
End date: 2018-07-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Our inability to accurately monitor the biodistribution of transplanted cells is a major barrier to assessing the safety and efficacy of cell-based regenerative medicine therapies. To assess safety, it is important to know if cells have engrafted into non-target organs so that possible adverse effects can be monitored over time; and to assess efficacy, it is crucial to know what proportion of cells reach the target organ, for how long they persist, and whether they ameliorate injury. Various imaging technologies, including magnetic resonance imaging (MRI), bioluminescence imaging and photoacoustic imaging can be used for monitoring cellular biodistribution and assessing the effect of the cells on host organs and tissues, but no single technique provides high sensitivity, spatial and temporal resolution, and functional and anatomical imaging. It is therefore necessary to combine several imaging approaches. The University of Liverpool is leading the UK Regenerative Medicine Platform Safety and Efficacy Hub. The hub includes all members of the supervisory team. The University has just inaugurated its new centre for preclinical imaging which brings together in a single place a unique suite of state of the art imaging modalities (including high field MRI and photoacoustic imaging). Building on her wide experience in the synthesis, functionalization and assembly of nano/micro-particles gained during her PhD with Irshad Hussain (Pakistan) and a Humboldt Fellowship with Wolfgang Parak (Germany), Sumaira Ashraf (the applicant) will prepare probes tailored for cell labelling and multimodal imaging. She will evaluate and optimize the properties of the probes following cell uptake (live cell imaging, magnetophoresis, etc) and finally test the most promising multimodal probes in mouse models of injury that are established within the UKRMP hub.

Keywords: cell tracking,gold nanorods,super paramagnetic iron oxide nanoparticles,photoacoustic imaging,magnetic resonance imaging,cell uptake,preclinical imaging
Developing Integrated Susceptibility and Conductivity MRI for Next Generation Structural and Functional Neuroimaging (DiSCo MRI SFN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2019-04-01
End date: 2024-03-31
Duration (months): 60.0
Total project cost (EUR): 1721726.0
EU funding (EUR): 1721726.0
Participants: 1
Project status: SIGNED

MRI is indispensable in the diagnosis of neurodegenerative diseases. These are poorly understood while their prevalence and socio-economic burden continue to rise. Structural and functional MRI can provide biomarkers for early diagnosis and potential therapeutic intervention. My research vision is to develop novel MRI methods for structural and functional mapping of tissue magnetic susceptibility and electrical conductivity as these show great promise for neuroimaging in diseases such as Alzheimer’s (AD). Susceptibility mapping (SM), which I pioneered, is uniquely sensitive to tissue composition including iron content affected in AD while conductivity mapping (CM) probably reflects cellular disruption in AD. Resting-state functional MRI (rsfMRI) reveals how AD affects brain networks without any tasks or stimulation equipment. However, each technique currently needs a separate time-consuming MRI scan. I will develop an integrated scan for simultaneous structural SM and CM, and rsfMRI functional connectivity characterisation. This efficient scan, ideal for AD patients, will reveal totally new resting-state networks based on electromagnetic properties: resting-state functional SM and resting-state functional CM for the first time. As changes in blood susceptibility underlie fMRI, rsfSM should measure functional connectivity more directly. This also makes it sensitive to physiological noise so I will develop noise removal methods building on fMRI techniques I established. Initial fSM studies have been at 7 Tesla but I will target the more widespread 3T field to maximise applicability. As a leader in both SM and rsfMRI physiological noise removal I have the ideal background to integrate SM and CM with fMRI and extend them for ground-breaking functional electromagnetic connectivity. This research will yield a rich set of novel, multimodal MRI contrasts to allow development of new combined structural and functional biomarkers for early diagnosis of AD and other diseases.

Keywords: electromagnetism
FUTURE-PROOF: Wide Area Monitoring and Protection Systems for the Future Grid (FUTURE-PROOF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-04-01
End date: 2021-02-28
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

This project seeks to advance the state-of-the-art in wide-area power system monitoring and protection systems, a critical component of future power systems, and vital to achieving the EU vision of a European Energy Union that delivers secure, affordable and climate-friendly energy. Crucially, the fellowship will bring together the complementary expertise of the applicant on power system protection, with the host organisation’s state-of-the-art wide-area monitoring infrastructure, and technical expertise in measurement technology, machine learning and big data analysis, enabling innovative research at the interface between these domains. Outputs will take the form of peer-reviewed journal articles and international conference papers setting out algorithms, and methodologies for robust and scalable monitoring and protection of future grids, and a power industry engagement workshop for knowledge transfer to key stakeholders. The complementarity of expertise of the host and the applicant ensures that knowledge transfer will be bi-directional and therefore the fellowship will be mutually beneficial. In line with MSCA objectives, the applicant, who is already an experienced academic and competent researcher, will diversify his research skills through mentoring and one-to-one technical training from domain specialists within the host team, as well as participation in selected advanced masters modules on MSc programmes offered by the host organization. In addition, the applicant will undertake a tailored professional training programme targeted at enhancing his senior management and leadership skills and well as his future collaboration and knowledge transfer with, and mobility within the EU.

Keywords: power system protection,wide area monitoring,phasor measurement units,big data
Living in Europe in the late Neolithic: A trans-disciplinary temporal perspective on present-day Europeans (NEO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

The genetic landscape of Europe has been extremely dynamic through time, in particular during the Neolithic transitions, and is thus difficult to redraw from the analysis of present-day populations only. Our understanding of the population migrations and cultural diffusion processes underlying the peopling of Europe has greatly advanced with recent developments in ancient DNA high-throughput sequencing. Surprisingly, despite the presence of large Neolithic human groups and its geographic location bridging Southern and Northern Europe, France is extremely under-represented in current Neolithic genomic dataset. Moreover, most recent studies focus on population migration at a global scale only, while epigenomes and oral microbiomes, which are impacted by external factors and influence the individual health and phenotype, can now be retrieved from ancient DNA sequences. NEO proposes to apply a multidisciplinary approach combining the latest advances in physical anthropology, isotopic methods, ancient genomics, metagenomics and epigenomics to two exceptional Neolithic human groups from France (Cave I of Treilles and Mont Aimé). NEO will enable us to decipher not only migration patterns and genetic ancestry, but also important aspects about life in past society, such as residential rules, funerary practices, health and diet. The success of NEO will be based on the excellent synergy between the experienced researcher and the host institution, as the applicant will benefit from state-of-the-art facilities and expertise to gain advanced training in physical anthropology methods, while applying her genomic skills to a sample set available at no other research institution in the world. By acquiring these new skills in an international context, the experienced researcher will become a fully trained evolutionary anthropo-genomicist at the interface of physical and molecular anthropology, which will place her in ideal conditions to develop as a mature and independent researcher.

Keywords: anthropology,ancient dna,neolithic,genomics,metagenomics,epigenomics,transition,diet,funerary practices,migration
from Cubic To Linear complexity in computational electromagnetics (321)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Italy,France
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: SIGNED

Computational Electromagnetics (CEM) is the scientific field at the origin of all new modeling and simulation tools required by the constantly arising design challenges of emerging and future technologies in applied electromagnetics. As in many other technological fields, however, the trend in all emerging technologies in electromagnetic engineering is going towards miniaturized, higher density and multi-scale scenarios. Computationally speaking this translates in the steep increase of the number of degrees of freedom. Given that the design cost (the cost of a multi-right-hand side problem dominated by matrix inversion) can scale as badly as cubically with these degrees of freedom, this fact, as pointed out by many, will sensibly compromise the practical impact of CEM on future and emerging technologies. For this reason, the CEM scientific community has been looking for years for a FFT-like paradigm shift: a dynamic fast direct solver providing a design cost that would scale only linearly with the degrees of freedom. Such a fast solver is considered today a Holy Grail of the discipline. The Grand Challenge of 321 will be to tackle this Holy Grail in Computational Electromagnetics by investigating a dynamic Fast Direct Solver for Maxwell Problems that would run in a linear-instead-of-cubic complexity for an arbitrary number and configuration of degrees of freedom. The failure of all previous attempts will be overcome by a game-changing transformation of the CEM classical problem that will leverage on a recent breakthrough of the PI. Starting from this, the project will investigate an entire new paradigm for impacting algorithms to achieve this grand challenge. The impact of the FFT’s quadratic-to-linear paradigm shift shows how computational complexity reductions can be groundbreaking on applications. The cubic-to-linear paradigm shift, which the 321 project will aim for, will have such a rupturing impact on electromagnetic science and technology.

Keywords: fast direct solvers,computational electromagnetics