Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SA.100: Next-generation targeted antibacterial product entering European market (StaphIMPACT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-07-01
End date: 2021-12-31
Duration (months): 30.0
Total project cost (EUR): 3978625.0
EU funding (EUR): 2495937.5
Participants: 1
Project status: CLOSED

According to the WHO, antibiotic resistance is one of humanity’s biggest health threats, claiming ~10 million extra deaths per year and US$100 trillion by 2050, unless alternatives to antibiotics are developed. Micreos has developed the world’s first targeted antibacterial products, set to replace antibiotics. With its endolysin technology, for the first time it is possible to kill only the unwanted bacteria, regardless of resistance. Micreos’ endolysin technology was chosen as Europe’s most relevant Innovation 2018 (Ideas from Europe). Its first lead endolysin, SA.100, kills only Staphylococcus aureus, including the resistant MRSA. Soft-launched under the Gladskin brand in the Netherlands, it’s having life-changing impact for thousands of people with inflammatory skin conditions caused or aggravated by S. aureus, including eczema, acne, rosacea and Hyper IgE syndrome. Micreos also develops products for diabetic wound infections and a skin cancer triggered by S. aureus. Micreos owns all relevant IP and know-how on its technology and produces its compounds and Gladskin products at small-scale at its facilities in the Netherlands. With this SMEi, Micreos prepares for full roll-out into the EU markets of its SA.100/Gladskin. This includes scale-up of production capacity, strengthening clinical evidence and communication of results to KOLs and relevant stakeholders. Leading pharma and cosmetics companies have expressed interest to in-license Micreos’ technology for particular indications. Relevant markets are the consumer’s skin care market ($177b by 2024; CAGR 4.7%) and dermatology market ($19.8b by 2023; CAGR 9.1%.). Own contribution by Micreos for this SMEi is already secured. This SMEi enables Micreos to take final steps for EU-wide roll-out, driving employment growth and company profitability, and helping people suffering from inflammatory skin conditions.

Keywords: targeted antibacterial product,endolysin,antibiotic resistance,mrsa,approved as medical device,medical skin care,cosmetics,staphylococcus aureus,technical scale up,inflammatory skin condition
TRADECOM: Trader communication, collaboration and compliance system (TRADECOM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Germany,Türkiye,United Kingdom
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-2-2014, 2014)
Start date: 2015-08-01
End date: 2018-07-31
Duration (months): 36.0
Total project cost (EUR): 2452933.75
EU funding (EUR): 1717053.63
Participants: 3
Project status: CLOSED

In the proposed project, TRADECOM: Trader communication, collaboration and compliance system, the project partners will develop and validate innovative hardware and software solutions to meet the communication, collaboration and compliance needs of financial services, energy and commodity trading and brokerage markets. The TRADECOM project partners will design and develop a new desktop communication endpoint (known as a trader turret) that will provide traders and brokers with high-quality, instant, private and secure group communications using intuitive user interfaces. The partners will also develop and implement necessary backend communication and media services to enable scalable, resilient and compliant call routing and recording via the internet and cloud services. The project will introduce new middleware that will link trader turrets to corporate computer systems, enabling turret functions to be accessed from enterprise applications (e.g. click-to-dial) and application data to be accessed from the turret (e.g. contacts and call groups). This will provide traders with more efficient ways to manage communications and workflow between the turret and other desktop systems. The TRADECOM turret will be designed to interoperate with Speakerbus’ emerging virtual turret (vTurret) services, which will replicate the TRADECOM trader communication services on desk and mobile devices. This will enable traders to work away from their main TRADECOM turret and still access specialist voice and data communication services. An important focus of the project will be to pilot and demonstrate the integrated TRADECOM systems in real operational environments and to assess the impact for traders and trading organisations. Taken together, these innovations will disrupt the trader voice market and its large incumbent technology suppliers, and provide high growth opportunities for the SME project partners.

Keywords: communication,turret,trading,compliance,collaboration,financial services,banking,finance
Prebiotic Synthesis of Pyrimidine Nucleosides: New Insights into RNA Evolution (PRENUCRNA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-05-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Understanding how life evolved on Earth is widely regarded as one of the most formidable challenges in modern science. The exploration of the mechanisms regarding the origin of life not only expands our understanding of natural sciences, but also provides new clues regarding the search for life forms and Earth-like conditions on planets other than our own. Ribonucleic acid (RNA) is widely regarded by the scientific community as the key molecule that gave rise to the origin of life. In order to support this “RNA World” hypothesis, scientists over the years have attempted to replicate the conditions present on the early-earth to afford nucleosides in a prebiotic manner. The lack of a uniform synthetic pathway affording canonical purine and pyrimidine nucleosides as well as non-canonical ones impedes our deeper understanding of the early evolution of RNA. Moreover, what has not been investigated in detail is the occurrence of a more primitive prebiotic molecule that might have evolved into RNA over the millennia. In this project, Dr. Okamura aims to study the prebiotic emergence of pyrimidine and pyrimidine-like nucleosides by developing a novel cyanoacetylurea pathway. This is expected to provide canonical as well as non-canonical pyrimidines under prebiotically plausible conditions. Using similar principles, novel pseudo-cyclic pyrimidines, inspired by the aforementioned pathway, will also be synthesized in order to examine their potential validity as candidates for primitive RNA. This project will provide new insight into the evolution of RNA as well as a deeper understanding of the origin of life. Moreover, it will aim to inspire novel approaches towards the European space exploration programs for the search of Earth-like conditions as well as life forms on other planets. This multidisciplinary field, where astrobiology meets prebiotic and nucleic acid chemistry will inspire and offer unique training to Dr. Okamura enabling him to embark on his own academic career.

Keywords: prebiotic chemistry,nucleic acid chemistry,nucleoside synthesis,rna synthesis,oligonucleotides,rna evolution,origin of life,space exploration
Cellular Position Tracking Using DNA Origami Barcodes (CellTrack)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-08-01
End date: 2022-07-31
Duration (months): 60.0
Total project cost (EUR): 1923262.5
EU funding (EUR): 1923262.5
Participants: 1
Project status: CLOSED

The research I propose here will provide an enabling technology; spatially resolved transcriptomics, to address important problems in cell- and developmental-biology, in particular: How are stem cells in the skin and gut proliferating without turning into cancers? How are differentiated cells related, in their transcriptome and spatial positions, to their progenitors? To investigate these problems on a molecular level and open up paths to find completely new spatiotemporal interdependencies in complex biological systems, I propose to use our newly developed DNA-origami strategy (Benson et al, Nature, 523 p. 441 (2015) ), combined with a combinatorial cloning technique, to build a new method for deep mRNA sequencing of tissue with single-cell resolution. These new types of origami are stable in physiological salt conditions and opens up their use in in-vivo applications. In DNA-origami we can control the exact spatial position of all nucleotides. By folding the scaffold to display sequences for hybridization of fluorophores conjugated to DNA, we can create optical nano-barcodes. By using structures made out of DNA, the patterns of the optical barcodes will be readable both by imaging and by sequencing, thus enabling the creation of a mapping between cell locations in an organ and the mRNA expression of those cells. We will use the method to perform spatially resolved transcriptomics in small organs: the mouse hair follicle, and small intestine crypt, and also perform the procedure for multiple samples collected at different time points. This will enable a high-dimensional data analysis that most likely will expose previously unknown dependencies that would provide completely new knowledge about how these biological systems work. By studying these systems, we will uncover much more information on how stem cells contribute to regeneration, the issue of de-differentiation that is a common theme in these organs and the effect this might have on the origin of cancer.

Keywords: dna nanotechnology,superresolution imaging,spatial transcriptomics,single cell sequencing
Early Upper Palaeolithic personal ornaments and behavioural adaptations (EU-BEADS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2018-12-14
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

EU-BEADS investigates symbolically mediated behaviour of Early Upper Palaeolithic modern humans through the study of personal ornaments. Specifically, EU-BEADS will focus on the Levantine region between 60,000 and 40,000 years ago. The goal is a better understanding of variation and standardisation in shell bead production and use, as well as establishing new criteria for identification of anthropic modifications of marine shell beads. To achieve this, EU-BEADS employs a range of state-of-the-art zooarchaeological and taphonomic methodologies in conjunction with newly learned analytical techniques namely finite element analysis, use-wear analysis and GIS. In addition, EU-BEADS aims to develop a new analytical method to improve quantification of human actions in the production of shell beadwork using geometrics morphometrics. The large shell bead collection of Ksar’ Akil (Lebanon) will serve as a case study. The high quality, multidisciplinary research results will contribute significantly to our knowledge of Early Upper Palaeolithic behavioural adaptations and of modern human symbolically mediated behaviours in general.

Keywords: modern human behaviour,early upper palaeolithic,zooarchaeology,use wear analysis
Podocyte Adaptation Proliferation and Ageing (PAPAstudy)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: France
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-03-01
End date: 2021-02-28
Duration (months): 60.0
Total project cost (EUR): 1479260.0
EU funding (EUR): 1479260.0
Participants: 2
Project status: CLOSED

My research project is focused on the biology of the podocyte during chronic kidney disease progression, one of the major public health challenges of the 21st Century. The podocyte is a highly specialized cell with foot processes expansion that function as vasculature-supporting cells, producing basement membrane components and a number of vascular growth factors. These cells play an essential role in renal physiology but their unique localization, as the primary filter, exposes them to many stresses in pathological conditions. In fact these cells are the direct target of many diseases such as diabetes or HIV. The molecular events and structural changes in podocyte during adaptation to nephron reduction are not well-characterized and efficient therapeutics dramatically lacking. In order to achieve the ultimate goal of improving care provided to patients suffering from renal failure, the dissection of the molecular pathways involved in podocyte adaptation and deterioration processes is mandatory. This project will combine complementary in vivo and in vitro approaches, experimental models of chronic kidney disease on genetically modified mice, as well as the use of a very innovative and new technology of bioengineering to explore the molecular and structural changes of the podocytes during kidney diseases. This work will be centralized on AKT2 and its partners, as we previously demonstrated its major role in podocyte adaptation to nephron reduction, but also on new players using unbiased approaches. In parallel and consistently with my previous works, we will systematically extend our findings to human through our unique Renal Biobank of Necker Hospital (Paris). The accomplishment of this project may lead to the discovery of novel therapeutic targets and strategies to slow down the progression of kidney disease.

Keywords: podocyte,nephron reduction,collapsing glomerulopathy
Enzymatic production of a novel class of nonionic, mild and biobased surfactants (ENBIOSURF)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Sweden
Call: SME boosting biotechnology-based industrial processes driving competitiveness and sustainability (H2020-SMEINST-1-2014, 2014)
Start date: 2015-03-01
End date: 2015-10-31
Duration (months): 8.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

A completely new class of non-ionic, biobased and mild surfactants that have been shown to have a number of advantageous technical features compared with commercial alternatives, have been produced using a novel enzymatically catalysed process (patent pending). This project aims at investigating the feasibility of a more economical route of their production to expand their market potential. The novel group of surfactants consist of oligomeric alkyl glycosides with head-groups substantially larger than those already on the market. The biocatalytic process developed is the only way such surfactants can be produced, and they have for the first time ever been produced in amounts that have allowed for their features to be established. Their mild and technically superior features render them extremely attractive for replacing ethoxylated surfactants such as the polysorbates in pharmaceutical formulations, thereby solving the problems of allergies and side-effects associated with the formation of oxidation products including formaldehyde. The new class of surfactants will, if the production cost is reduced, also be very attractive for the cosmetics- and personal care markets including a large number of European cosmetics companies. The cosmetic sector has a large need for both replacing ethoxylated surfactants and introducing “green” ingredients that can be accepted under for instance the Cosmos standard, a European standard for organic and natural cosmetics. The mild and green features of the oligomeric alkyl glycosides make them very attractive for this sector. This project aims at investigating the bottle-necks for achieving a more economical process including type of raw material, re-use of material, conversion, downstream processing etc. This will prepare for scaling up and a larger market introduction which will be the aim for a project proposal for phase 2 funding, after which a partner deal including licensing and/or acquisition is expected.

Keywords: surfactant,biobased,green,non ionic,alkyl glycoside,enzyme technology,biocatalysis,biotechnology process,cost efficiency,biodegradable
COFUND BIST PREDOCTORAL PROGRAMME (PREBIST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,Spain
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2016, 2016)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 5859840.0
EU funding (EUR): 2929920.0
Participants: 6
Project status: SIGNED

The PREBIST proposal is presented by the Barcelona Institute of Science and Technology (BIST) as beneficiary. PREBIST is an ambitious programme of 28 four-year fellowships for multidisciplinary pre-doctoral research at BIST´s constituent research centres and associated partner institutions (hospitals, private companies, technology centres, and other academic institutions), who will provide secondments, training, networking activities and other actions to complement the research activities and professional development of the fellows. The PREBIST proposal is a major initiative by which BIST aims to leverage the combined capacities of the constituent centres in a manner which none of them could do on their own and help achieve the strategic objectives of BIST. Key objectives of PREBIST are to: • Boost the capacity for international talent attraction with increased visibility, strengthened recruitment processes, improved offerings of research areas with interdisciplinary and intersectorial aspects, and improved landing-pad processes to facilitate mobility; • Improve BIST centre capacities in the management of researcher career development, scientific and technical training, and new offerings in complimentary skills training and outreach activities; • Further drive interdisciplinary and intersectorial collaboration between BIST centres and other partner entities through joint research activities, secondments and technical trainings, improved access and utilisation of infrastructures, networking and development of personal contacts, joint seminars and workshops.

Keywords: doctoral training,biomedicine,nanotechnology,nanoscience,physics,astrophysics,chemistry
Population genomics and experimental evolution of ribosomal RNA gene variants in Arabidopsis thaliana (rDNAevol)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The central importance of ribosomal RNA genes (rDNA) for our understanding of biology cannot be overstated: they are evolutionarily the oldest genes, they are the most highly expressed genes in any organism, and their expression is central to cellular growth. Because of the requirement for large quantities of rRNA, eukaryotic genomes contain clusters with hundreds to thousands of rDNA copies arranged in tandem. Despite their high copy number, there is little sequence variation across all rDNA genes within an individual and across individuals in a given species, due to the still mysterious process of concerted evolution. Since not all rDNA copies are expressed, we can already suspect that selection cannot act directly on all rDNA copies. Although our understanding of concerted evolution, and the molecular mechanism how it is achieved (homogenization), has improved over the last decades, no attempt to study it in the context of silent or active rDNA clusters has been made. In the described research programme I will take full advantage of the model plant Arabidopsis thaliana to attack this important connection. The diversity of genetic resources available such as experimental populations to effectively unlinked its two rDNA clusters, the large catalog of over 1,001 publicly available re-sequenced genomes combined with corresponding expression data, as well as its accessibility for genetic manipulation make it an ideal system to pursue the following specific aims: (1) Perform a population genomic analysis of the sequence variability within silent and active rDNA clusters, (2) Generate targeted induced mutations in rDNAs by genome editing to (3) describe the fate and fitness of both natural rDNA variants and newly induced mutations.

Keywords: rdna,rrna genes,crispr cas9,natural variation,population genomics,experimental evolution,arabidopsis