Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Modification and regulation of coding and non-coding RNA pathways (moreRNA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-06-01
End date: 2021-05-31
Duration (months): 60.0
Total project cost (EUR): 1998316.0
EU funding (EUR): 1998316.0
Participants: 1
Project status: CLOSED

Coding and non-coding RNAs are regulated at numerous levels. For example, microRNA (miRNA) expression can be influenced at various steps of biosynthesis. Furthermore, it has been reported that direct RNA methylation events can also affect gene expression in many different organisms and systems. The aim of this project is to identify and characterize factors that affect the maturation of miRNAs. We will employ biochemical pull down assays to isolate specific binding partners of different miRNA species. We will analyze the physiological role of these factors using molecular or cell biological approaches. Molecular details of pre-miRNA-protein interactions will be investigated by x-ray crystallography. In addition, we will decipher the role of the m6A methylation pathway on the regulation of coding and non-coding RNAs. Writers, readers and erasers of this modification have been identified. However, not much is known about the composition of specific protein complexes as well as the atomic structure of these factors. Thus, we will functionally and structurally characterize known and putative novel factors of the m6A methylation pathway in human cells. Furthermore, using our biochemical pull down approach employed for the identification of pre-miRNA processing factors, we will identify reader proteins of several types of RNA modification that have not been investigated so far. The proposed project will elucidate the regulation of gene expression by small RNAs or direct RNA methylation and will add so far unknown components to these important regulatory pathways.
Accelerator and Research reactor Infrastructures for Education and Learning (ARIEL)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Support the development of nuclear competences at Union level and socio-economic aspects
Action type: Coordination and support actions
Countries involved: Germany,Spain,Spain,Germany,Spain,Italy,Germany,Norway,Finland,Sweden,Switzerland,Belgium,Hungary,Romania,Slovenia,France,France,France,France,Czechia,Netherlands,United Kingdom
Call: Availability and use of research infrastructures for education, training and competence building (NFRP-2018, 2018)
Start date: 2019-09-01
End date: 2024-02-29
Duration (months): 54.0
Total project cost (EUR): 1998670.0
EU funding (EUR): 1998670.0
Participants: 26
Project status: SIGNED

For the continuing improvement of the safety of current and planned nuclear facilities accurate and precise nuclear data are required to simulate the ongoing processes on the atomic level. In order to maintain the transfer of knowledge to the younger generation and to countries with less advanced nuclear programs the most modern and state of the art neutron beam facilities based on accelerators and research reactors will unite in this project international experts with interested early stage researchers (ESR) and technicians to work on the most challenging problems. Experimental work in international teams at these facilities will be the most effective training and competence building tool. The project will provide at least 3000 additional beam time hours for external users groups at the neutron facilities of the consortium. Up to 90 ESR and technicians will be able to receive full mobility and logistical support to participate in these experiments at 23 different accelerator or reactor based neutron facilities. The training of ESR in the field of nuclear physics and nuclear engineering will be complemented by up to 30 research stays of up to 12 weeks duration for extended work at the participating facilities. These activities, which are also open to senior scientists and now also to technical and professional staff, will continue to foster the exchange of knowledge that has grown in earlier EURATOM work programmes, e.g. within CHANDA, or ERINDA. The scientific proposals for experiments and training of ESR will be selected by a Project Advisory Committee consisting of high-level experts based on scientific excellence and relevance to improve nuclear safety and support of current nuclear data needs as addressed by IAEA and NEA. In order to increase the visibility and attractiveness at the university level four summer schools with about 80 participants shall be organized, where the wider target group should be students with physics and engineering backgrounds.
Structural insights into binding signatures of transcription factors regulated by HIPPO signalling (HIPPOSTRUCT)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Czechia
Call: Widening Fellowships (H2020-WF-02-2019, 2019)
Start date: 2020-06-01
End date: 2022-05-31
Duration (months): 24.0
Total project cost (EUR): 156980.64
EU funding (EUR): 156980.64
Participants: 1
Project status: CLOSED

Transcription factors (TFs) are proteins which recognize specific DNA-sequence to orchestrate various gene expression programs according to cellular requirements. Currently, approximately 1,600 TFs along with their binding motifs have been annotated. Further, recent studies enabled classification of many of them according to their binding modes across nucleosome assembly. Despite such progress, interplay of different TFs in the context of adjacent DNA sequence or spatial organisation of chromatin is still largely unknown. This project aims to dissect crosstalk between different TFs that are targeted by HIPPO signalling pathway, a tumour suppressor pathway representing potential target for anti-tumour therapies. Preliminary data from host lab combined with previous studies from other groups lead us to postulate hypothesis that TFs from TEAD and FOX groups cooperate on regulation of transcription programs controlled by HIPPO pathway. Specifically, FOX TFs act as chromatin re-modellers enabling TEADs binding to the naked part of DNA which then triggers desired gene expression programs. To test this hypothesis, we will combine bioinformatic searches across human genome with experimental work assessing intermolecular binding between TFs and DNA, followed by structural characterization of selected macromolecular complexes. We will identify genomic loci which contains binding motifs for both TEAD and FOX TFs. These DNA fragment will be tested experimentally in terms of their ability to physically interact with both TFs, which will provide mechanistic insight into their cooperation. Finally, 3-D structure of the reconstituted complexes containing TF pairs bound to DNA will be determined using advanced mass spectrometry combined with high-resolution structural techniques such as X-ray crystallography and cryo-electron microscopy. This project will provide insight how TFs cooperate in the relevant genomic context with physiological chromatin architecture.

Keywords: transcription factors,hippo signalling,integrative structural biology,protein dna complexes
Dissecting the functional pathways of B cell receptor immunoglobulin in antigen driven mature B cell lymphomas (IGpath)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Greece
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 152653.2
EU funding (EUR): 152653.2
Participants: 1
Project status: CLOSED

The B cell receptor immunoglobulin (BcR IG) is important for the ontogeny and evolution of malignancies of mature B cells (B cell non-Hodgkin lymphomas, B-NHLs), mediating critical interactions with the microenvironment, including recognition of and selection/activation by antigens. Of note, inhibition of BcR IG-mediated signaling has emerged as a highly efficacious treatment mode for these tumors, highlighting their dependence on extrinsic triggering. Nevertheless, open issues abound regarding the precise role of the BcR IG in lymphomagenesis, particularly regarding the range of interactions with antigens and their functional impact on clonal behaviour and patient outcome. IGpath is an original multidisciplinary project combining innovative methodologies with the aim of dissecting BcR IG-related mechanisms and processes implicated in the pathogenesis of mature B-NHLs. The focus will be on splenic marginal zone lymphoma (SMZL) and chronic lymphocytic leukemia (CLL), and monoclonal B lymphocytosis, a pre-malignant condition that is considered as a potential precursor state to CLL. IGpath is grounded on the combination of the applicant’s scientific background and skills with the expertise and infrastructure of the Host, thus guaranteeing the bidirectional transfer of knowledge. Therefore, it is anticipated to lead to novel insight into the fundamental mechanisms of lymphomagenesis, holding the potential to identify novel actionable targets and novel prognostic/predictive biomarkers. Moreover, thanks to a carefully designed research strategy and implementation plan, the applicant will acquire valuable skills in novel techniques, project management, and networking, thus setting the basis for an independent career in science.

Keywords: b cell non hodgkin lymphomas,immunoglobulin,b cell receptor,antigen,pathogenesis,immunogenetics,analytical ultracentrifugation,dilution isothermal titration calorimetry
RADIAtion source of Light for picosecond laser pulse applications (RADIAL)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Switzerland,France
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-4, 2020)
Start date: 2021-09-01
End date: 2022-06-30
Duration (months): 10.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

The RADIAL project aims at developing a novel type of radiation source producing ultrashort light pulses in a burst and at will. It is based on a state of the art solid-state superradiant emitter developed in the frame of the SUPERTWIN project. Based on advanced III-V alloy epitaxial growths and wafer processing techniques the solid-state emitter utilizes the cooperative effect of Dicke superradiance (super-fluorescence) emission and is capable to produce on demand sub-picosecond 60-100 pJ energy optical pulses in the near –infrared spectral range (800 nm wavelength). A main objective of the project is to identify the various applications for such radiation source and to demonstrate the ability of the source to achieve the respective requirements. Finally a market study of the most promising applications will be performed. Preliminary analysis is pointing on the partial replacement market of large Ti:S mainframe lasers used in two-photon fluorescence lifetime imaging, THz antennas, quantum optics as well as on the market of pulsed lasers for LIDAR applications.

Keywords: superfluoresence,dicke superradiance,ultrafast lasers
Accurate Full-Field 3D Shape Measurement Technique of Specular Surfaces by Phase-to-Depth Deflectometry (3DRM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-08-01
End date: 2018-07-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

With the advent of advanced manufacturing technology and the advent of intelligent manufacturing, it is becoming more and more important to fast and accurately measure 3D shape of components surface, especially specular objects, in the process of intelligent manufacturing, which is a guarantee to improve the product quality. This project will solve the challenging problems in deflectometry. If successful the project will open the door to a host of new instrumentation devices. The project will address the fundamental problems how to avoid the integration procedure in deflectometry - a problem that has seriously obstructed the development of measuring the complicated specular surfaces. I propose a novel direct phase-to-depth deflectometry for accurately measuring full-field 3D shape of specular objects with isolated and/or discontinuous surfaces. In addition, I will develop a new instrumentation system using the phase-to-depth deflectometry technique. Two new techniques and research methods will be studied to realize phase-to-depth deflectometry: 1) display the same fringe patterns on two screens, 2) display two set of fringe patterns on one screen. A novel 3D calibration method will be developed to determine the relationship between phase map and 3D shape data by using a white plate and a plane mirror, both having ring marks on the surface. Such application will greatly promote 3D measurement technologies and should lead to significant economic and societal benefits to Europe. Through this Fellowship, I will gain new knowledge and training about advanced optical metrology to keep the international standing as a leading researcher. Therefore, this Fellowship has not only important practical application value in quality assurance of products in the fields of intelligent manufacturing, but important theoretical significance for research and developments in optical metrology.

Keywords: deflectometry,3d shape measurement,complex specular surfaces,3d calibration
The influence of Environmental Variability On Mussel Aquaculture and adaptation in the context of global ocean change (EVOMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-11-16
End date: 2020-03-06
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Global ocean change (GOC, including warming and acidification) poses one of the largest threats to marine fisheries and aquaculture. Yet, there are still few predictive consequences, due to the limited understanding of species’ in situ responses. Recent studies suggest that spatial differences in environmental conditions influence physiological tolerances of marine populations. This project tests the hypothesis that environmental variability of multiple stressors (temperature, pH, salinity) enhances physiological hardiness of sensitive early life-stages of an economically valuable mollusk, the mussel Mytilus galloprovincialis. The project implements a novel, three-pronged, multidisciplinary approach using (1) population comparisons to assess performance of mussels from sites of low and high environmental variability, (2) mild stress exposures to test for enhanced physiological performance in the field, and (3) larval cultures to assess proteomic responses to temporal variability of multiple stressors and carryover effects to juveniles. This project includes collection of oceanographic time-series data at field sites (including at an aquaculture farm), with state-of-the-art pH sensors, to identify frequency of stress events and inform experimental design. This still rare approach, using in situ data with laboratory studies, improves environmental realism in GOC studies. The project addresses a crucial gap in the current understanding of coastal environmental variability and multiple stressors and has direct application to aquaculture practices. By combining the researcher’s and host’s expertise on marine physiology related to GOC pressures, this project will advance innovations in the field of GOC biology, state-of-the-art pH sensor technology transfer, and applied proteomics, and will thus become an important step forward in the career of a Researcher dedicated to GOC biology, and strengthen European expertise in these fields.

Keywords: stress hardening,adaptive capacity,carryover effects,larval development,durafet ph sensors
Energy efficient and sustainable building planning (SEMERGY)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Austria
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2015-08-01
End date: 2015-10-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Buildings are responsible for 40% of the energy consumption and 36% of greenhouse emissions in the EU. 80% of the buildings we will occupy in 2050 are standing today, with adequate measures, they have the potential to reach 70% reduction in their GHE gas emissions and energy savings worth €270 billion per year. The market for Energy Efficient Building product and services in Europe amounts €41 and growing at a 10.3% CAGR. However, building owners, when considering alternatives in a design or retrofit project, are challenged by high investment costs, uncertainty about savings and the complex nature of the domain. These are the main barriers preventing a wider adoption of building refurbishing projects. At Xylem Technologies, Austrian SME established in 2009, we are focused on the development of fundamentally new tools aimed towards a lower carbon economy. In lieu of the potential in EEB we started development of Semergy to provide the methodologies and ICT tools necessary to stimulate energy efficiency retrofitting. The architecture of Semergy is based on a novel and unique application of semantic web technologies (ontologies) that enable systematic retrieval and reorganization of data from multiple sources available on the Internet. No other commercial tool has this capacity and reduces the design effort by 70%. Building owners will be able to assess technologies available for their specific need with our Decision Support System that interactively compare retrofit options against criteria of cost, energy reduction and sustainability. Contractors will access a pool of building owners in our Marketplace and enhance efficacy of the design with the Optimization Environment. As a result, for EEB product and services providers, Semergy will provide a unique Product Placement Tool. They benefit from direct access to a curated target audience. Conversion rate is increased by being specified early in the design phase and just one sale compensates the cost of Semergy.

Keywords: building energy efficiency,software,semantic technologies
Spatial Decision Support System for Transportation Planning (SIADE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

SIADE is a GIS-based decision support system for public transportation planning. It facilitates the process to improve efficiency in public transportation, with an special emphasis in social and economical parameters. Implementing a strategy to manage urban transportation involves several mathematical models allowing transportation network analysis and estimating their impact in both the environment and the users, while defining automatic procedures to compare different scenarios.

Keywords: transportation planning,smart cards,adc sytems,intellingent transportation systems
Experiencing Historical Soundscapes: the Royal Entries of Emperor Charles V in Iberian Cities (ExpSoundscapes)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

This project aims at bridging the gap between describing, reflecting on, and experiencing historical soundscapes. It will integrate historical, sensorial, and artistic approaches so as to retrieve the soundscapes of Early Modern Royal entries in Iberian cities in the time of Emperor Charles V (1517-58). Sonic information will be extracted from coeval documentation to be analysed and organised in a database and georeferenced in a map through GIS technology. The sound data will serve as the basis to create an immersive multimedia event, where selected sonic scenes will be reproduced by engineered sound and live music. The spatial surroundings will be recreated through historical paintings and 3D renditions of selected urban spaces. The immersive event will be a highly distinctive experience, with the potential to transform the traditional understanding of historical events by introducing elements of sensorial scholarship. It will facilitate exposure of high-quality repertoire within specific historical events. Likewise, the project will explore new avenues of the possibilities that the use of digital technologies provides to the understanding of music historical subjects (as postulated by European policies such as 'Digital Futures') and its management as intangible heritage. This research will make academic impact at different levels. The most significant will be the establishment of a groundbreaking methodology to facilitate the experiencing of sensorial experiences of the past, drawing on a phenomenological perspective. It will provide complementary tools to the traditional understanding of historical soundscapes, fostering interdisciplinary collaboration that will bring together areas such as music, history, geography, performance, and technology. Ultimately, it will open alternative pathways to communicate historical events to modern audiences.

Keywords: soundscapes,urban musicology