Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The anthropology of the future: An art world perspective (ANTHROFUTURE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Austria,United States
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2499911.0
EU funding (EUR): 2499911.0
Participants: 3
Project status: SIGNED

The future has been neglected as an object of anthropological study, even though our complex social, ecological and now, with COVID-19, biopolitical crises demand novel imaginations of the ‘yet-to-come’. Moreover, anthropologists have urged the decolonisation of existing studies of the future that are often based in the global north’s concerns. ANTHROFUTURE shifts the focus of the anthropology of the future to the pandemic-induced acceleration of the future into the present. The project identifies the art world – historically featuring a high degree of experimentalism, a strong future-orientation, and, particularly in emerging markets in the global south, an openness to risk and speculation – as a crucial site for ground-breaking anthropological knowledge on the future. The pandemic forced the art world to quickly develop innovative digital solutions to replace physical events; the result is a new, fully integrated physical and digital system. While pre-pandemic scholarship on the art world largely focuses on institutions, professionals and activities as physical phenomena, there is no scholarship on this new digital-physical infrastructure. ANTHROFUTURE further acknowledges the global south as the most vital site for modeling the future by situating its research in India and Pakistan as active and mutually entangled art world locations. ANTHROFUTURE introduces three novel modes of inquiry: 1) systematic research on the digital-physical art world as an ethnographic site for the study of the future; 2) innovative multimodal methodologies for studying the future that combine in-person, digital and visual ethnography, large-scale social media data harvesting, and artist subprojects; 3) analytical and theoretical advancements on the future as a time zone in comparative terms and across the regional contexts. Embedded in anthropology, the project pursues these objectives driven by the PI’s extensive research on the past and present of the art world and the global south.

Keywords: art world,future,digital worlds
Disrupting the horticulture industry with smart lighting solutions (miniSun)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-12-01
End date: 2025-03-31
Duration (months): 28.0
Total project cost (EUR): 2717917.5
EU funding (EUR): 1902542.0
Participants: 1
Project status: SIGNED

Artificial lighting systems are holding back wide adoption of vertical farms due to 1) high energy costs, and 2) inability to fully replicate the sun spectrum. It also affects greenhouses´ profitability, as they also depend on artificial lighting systems. miniSun is the most energy-efficient lighting system for the horticulture industry -50% reduction compared to existing technologies-, able to fully mimic the sun spectrum based on ground-breaking luminaires that combine proprietary LED and smart driver technologies with state-of-the-art sensors and AI/ML algorithms. With miniSun, indoor farming becomes profitable for a variety of crops -e.g. cucumber, berries, tomato, pepper-, making it possible to grow them in vertical farms for the very first time. Our circular business model -low CAPEX/OPEX, recurring revenues over time- will enable rapid growth. Our vision is to become a world leader in the horticulture LED lighting market, addressing a 10% of the market share by 2030.

Keywords: led technology,crop growth,greenhouses,indoor farming,vertical farming,nano engineering,nano materials,green gap
Decoding and Targeting Treatment-Resistant Metastatic Neuroblastoma (Decode Relapse)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The childhood cancer neuroblastoma (NB) is a major challenge in pediatric oncology, and children with relapse have a very poor prognosis due to treatment-resistance at metastatic sites. There is an urgent need to better understand NB treatment resistance to inform the design of novel therapeutic strategies. However, current models do not mimic relapsed human NB in its most common metastatic niches in the bone and bone marrow. We recently developed advanced patient-derived and humanized NB in vivo models and 3D tumor organoid models which are excellent tools for preclinical drug testing. Here, we aim to further develop and exploit these models, investigate mechanisms of NB metastatic treatment resistance/relapse, and target relapsed NB with combination therapies. First, we will develop patient-derived in vivo and ex vivo models of relapsed NB in the human metastatic bone marrow niche exposed to standard-of-care chemotherapy treatment. These models will be exploited to investigate mechanisms of metastasis and treatment escape upon therapy and at relapse. We will integrate NB and stromal cell lineages, cell states and molecular details with phenotype and drug response, and elucidate NB tumor cell plasticity and clonal evolution. The mechanistic data and our new models will help us to identify novel therapeutic targets and compounds targeting relapsing and resistant NB, which we will validate experimentally. The project will lead to a deeper understanding of NB metastatic treatment resistance and identification of novel cell state-directed treatments to target resistant and metastatic disease. My combined background in clinical medicine/pathology, in vivo/ex vivo modeling, NB chemoresistance, and preclinical drug testing coupled with development and application of state-of the-art advanced assays will generate the next generation of patient-derived models, mechanistic insight and novel treatment against relapsed NB.

Keywords: treatment resistance,relapse,metastasis,neuroblastoma,pediatric cancer,mouse model,pdx model,tumor organoid,tumor cell state,tumor microenvironment,preclinical drug testing
Peptide-based Supramolecular Co-assembly Design: Multiscale Machine Learning Modeling Approach (SupraModel)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 1474182.5
EU funding (EUR): 1474182.0
Participants: 1
Project status: SIGNED

Supramolecular self-assembly is a fundamental process abundantly utilized by nature and emerging functional materials technologies ranging from drug delivery to soft semiconductor devices. Recently, an increased focus has been placed on the multicomponent peptide co-assembly as they often display unique emergent properties that can dramatically expand the functional utility of peptide-based materials. Still, the full potential is hindered by the combinatorial complexity of peptide-based materials and our inability to predict the co-assembled structures and, therefore, properties and functionality. Machine Learning models built on top of Molecular Dynamics simulations are ideally suited to decipher the co-assembly behavior. However, the existing molecular models either suffer from severe approximations disabling them to give accurate predictions or are computationally too expensive to transverse the material space. Addressing this trade-off, I aim to develop a computational framework for fast and accurate peptide co-assembly prediction using as a key strategy a multiscale construction of Graph Neural Network-based models that can predict the peptide co-assembly. This innovative approach will enable me to reach the following objectives: (1) obtain unprecedented molecular insight into the peptide co-assembly process inaccessible to experiments, (2) uncover novel candidate materials, and (3) provide rational design rules for multicomponent peptide-based supramolecular materials. In a broader context, increased insight into cooperative behavior will bring us closer to understanding and ultimately synthetically replicating the exceptional functionality of living systems, while the methodological advancements of data-driven molecular modeling will be of paramount importance in other areas of biomaterial engineering and beyond.

Keywords: biomaterials,machine learning,multiscale modeling and simulations,molecular dynamics
Novel advanced hydraulic CO2 refrigeration system for multiple sectors (HYDROCOOL)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Spain,Israel,France,Luxembourg
Call: EIC Pathfinder Challenge: Clean and efficient cooling (HORIZON-EIC-2023-PATHFINDERCHALLENGES-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 2511105.0
EU funding (EUR): 2511105.0
Participants: 7
Project status: SIGNED

The cooling production, coupled with renewable electricity generation, are considered a cornerstone technology to meet increasing global cooling demand whilst decarbonise various sectors. According to the International Energy Agency, only accounting the air-conditioning sector, consumes about 20% of the overall electricity used globally and is expected to be doubled by 2050. Improving the efficiency, reliability, affordability, and environmental performance of cooling systems is critical to maximum benefit for society and the environment. HydroCool project will develop a novel cooling production concept that can significantly improve the cooling system performance beyond the state-of-the-art. The solution is based on the hydraulic compression and expansion of CO2 in a reversible cycle capable of delivering cooling for a wide range of application such as food, data centres or air conditioning [-40ºC;+12ºC]. By switching from solid to fluid dynamics, HydroCool will enable both isothermal compression using liquid piston fluid and energy recovery between expander and compressor. Preliminary studies indicate a potential to nearly double the Coefficient of Performance through these two mechanisms. The hydraulic compression is also expected to lead to a significant improvement of the system lifespan, operating cost and reliability due to reduced friction and limited use of lubricants. Additionally, HydroCool offers an opportunity to accelerate the move in favour to CO2, displacing the use of environmentally harmful HFC and CFC refrigerants with high Global Warming Impact, that combined with the high system performance, improves considerably the cooling sector footprint by almost halving its impact. Thus, HydroCool will improve the affordability, performance, sustainability, and scalability of the CO2 based refrigeration system. In the project, a hydraulic CO2 cooling system will be engineered, implemented, and tested at 17.6kW scale to achieve TRL4.

Keywords: cooling,r744,co2 transcritical cycle,co2 compression,hydraulic compression,fluid dynamics,co2 subcritical cycle,liquid piston fluid
Hybrid collective quantum states of optically trapped neutral atoms and nanoparticles (HYQAP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499116.0
EU funding (EUR): 1499116.0
Participants: 1
Project status: SIGNED

Generating non-Gaussian quantum states of motion of an optically trapped silica nanoparticle has been a long-standing goal in levitated optomechanics. The main challenge is that its oscillation amplitude in the quantum ground state is orders of magnitude smaller than any pertinent nonlinear optical potential. Conversely, the wave packet size of an optically trapped neutral atom in its ground state is comparable to the laser wavelength, making it straightforward to prepare macroscopic superposition states through state-dependent forces. This project aims to generate collective quantum states of the motion of a single neutral Cesium atom and a silica nanoparticle. The intrinsic interface provided by the optically mediated interactions offers a feasible route for realizing genuine non-classical states in the nanoparticle’s center-of-mass degree of freedom. My research will focus on three objectives: (i) creating hybrid tweezer arrays of atoms and nanoparticles, (ii) interfacing them through light-induced dipole-dipole interaction, and (iii) leveraging this coupling to entangle the atom and particle motion. Altogether, this will enable the transfer of non-Gaussian states of motion from the atom to the particle, with potential applications for genuine quantum-enhanced sensing and the measurement of Casimir forces and blackbody radiation. The Hybrid Quantum Atom-Particle (HYQAP) platform becomes possible through a unique synergy of novel methods from quantum optomechanics and atomic physics. Specifically, a high-finesse optical bowtie cavity that enables quantum coherent control will be integrated with tweezer arrays created by acousto-optical deflectors for arbitrary dynamic shaping of traps and interactions, while the single-site imaging will allow us to read out the collective states. These methods have been demonstrated independently for atoms and silica particles, rendering this the ideal moment to bring them together into a hybrid quantum system.
Identification of cellular regulators and pharmacological inhibitors of endophilin-A3 to modulate its endocytic functions (ModulEndoA3)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium,France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 2
Project status: SIGNED

In addition to classical clathrin-mediated endocytosis, mammalian cells have clathrin-independent endocytic (CIE) mechanisms. Among others, the BAR domain proteins, that sense and induce membrane curvature, are key players in CIE. In particular, the BAR domain protein endophilin-A3 (endoA3) drives CIE of the cell adhesion molecules CD166, L1CAM, and DICAM, with implications in tumour progression and viral infection. The regulation, mechanism, and functional implications of this recently-identified endoA3-mediated CIE route remain poorly characterized. In this context, I propose an interdisciplinary project combining cell biology, chemical biology, and virology approaches to substantially advance our understanding of endoA3-mediated CIE. The first research goal is to identify cellular regulators (kinases, phosphoinositides) that modulate endoA3-mediated endocytosis. In parallel, this project aims at identifying small molecule inhibitors that selectively inhibit the endocytic functions of endoA3. Subsequently, the cellular regulators and pharmacological inhibitors identified in this project will be used in cells, to modulate endoA3-mediated endocytosis and study the impact on cellular functions. Emphasis will be put on cancer cell properties and endocytic viral particle entry. Together, this project will generate high-quality fundamental knowledge on the mechanism and function of endoA3-mediated CIE. Moreover, the identification of modulators of endoA3 endocytic functions will provide valuable biological tools for the study of this recently-identified CIE route in physiology and pathology. Lastly, the identification of selective pharmacological inhibitors may pave the way towards the development of innovative antiviral and anti-cancer therapeutics targeted at unconventional endocytosis. This fellowship will be conducted in the laboratory of Prof. Henri-Francois Renard (UNamur, Belgium), who has been a pioneer in the identification of BAR-mediated endocytic routes.

Keywords: membrane trafficking,clathrin independent endocytosis,bar domain,endophilin,kinase,phosphoinositide,small molecule inhibitors,cancer,virology
ENVIRONMENTAL EXPLOITATION OF POLITICAL ECONOMICS (EXPLOIT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Norway
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2029-11-30
Duration (months): 83.0
Total project cost (EUR): 1904046.0
EU funding (EUR): 1904046.0
Participants: 1
Project status: SIGNED

We need a theory to explain why society has so far failed to address climate change and other environmental problems. After all, it has been able to deal with other challenges, ranging from wars to trade barriers and, most recently, Covid-19. In this project, we seek to shed light on two important questions: I. What political economics forces explain the failure to deal with environmental problems? II. How can environmental agreements and contracts exploit domestic political forces? The first, positive, part seeks to develop dynamic political economics models that can be combined with models of climate change and other environmental problems. The goal is to learn more about what political economics forces or constraints are best able to explain the observed inefficiencies in environmental policies. This knowledge is necessary before we can analyse which policies are best – subject to the relevant constraints. The second, normative, part is more groundbreaking because it investigates how international environmental policies can exploit the political forces that are important at the domestic level. Intuitively, when desirable policies are hindered by political forces, such as present bias and time inconsistency, an incumbent may value a treaty that offers pre-commitments or credibility. This value implies that the incumbent can be persuaded to contribute more (to emission cuts, for example) if the agreement is designed so that it helps the incumbent overcome domestic political constraints. By drawing on contract theory and organizational economics, we will investigate how international policies can exploit time-inconsistent incumbents’ demands for commitment, how status-quo biases offer credibility, and how inattention permits persuasion. The project will contribute methodologically to political economics and contract theory. The lessons for policymakers may be invaluable.

Keywords: environmental economics,political economics,contract theory
Cross-Border Cultural and Creative Tourism in Rural and Remote Areas (CROCUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Denmark,Netherlands,Slovenia,Finland,Italy,Bulgaria,Croatia,Estonia,Hungary
Call: Fostering socio-economic development and job creation in rural and remote areas through cultural tourism (HORIZON-CL2-2023-HERITAGE-01, 2023)
Start date: 2024-04-01
End date: 2027-03-31
Duration (months): 36.0
Total project cost (EUR): 2799733.75
EU funding (EUR): 2799733.75
Participants: 10
Project status: SIGNED

Rural and remote areas (RRA) are rich in cultural heritage, but many also suffer from socio-economic problems such as an ageing population, out-migration, and low incomes. Cultural and creative tourism (CCT) could help address these problems by creating sustainable jobs and investment, but three key challenges and associated knowledge gaps must be overcome: (1) place-specific business models that suit different types of cultural heritage and community needs must be created; (2) tourism development must be balanced and sustainable; (3) policies at different scales should support cooperation between RRA. CROCUS addresses these key challenges by: (a) generating knowledge about which CCT business models are most appropriate for different types of heritage and rural areas; (b) creating eight cross-border living labs in which sustainable CCT business models will be prototyped (16 in total); (c) developing macro-regional and cross-border policy scenarios for each of the four EU macro-regions (Baltic Sea, Adriatic and Ionian, Alpine, and Danube); and (d) synthesising knowledge and experience from the project to create tools and resources that RRA across Europe and beyond can use to develop sustainable and inclusive CCT in the future. CROCUS will achieve this through its ambitious multi-scalar research design, innovative cross-border living labs, and participatory processes of sustainable business model prototyping. The consortium brings together leading scholars and practitioners that have extensive experience with cross-border tourism development projects, stakeholder engagement, and policy analysis. It will be the first systematic study of different types of cross-border CCT cooperation in RRA. The impact of CROCUS will be to increase sustainable and inclusive CCT and cross-border cooperation in RRA across Europe, thus unleashing the potential of cultural heritage as a driver of sustainable innovation.

Keywords: rural development cultural heritage tourism studies cultural tourism creative tourism