Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Flexible Work, Rigid Politics: The Nexus Between Labour Precariousness and Authoritarian Politics in The Global South (Brazil, India, Philippines) (WorkPoliticsBIP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Ireland
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1998711.0
EU funding (EUR): 1998711.0
Participants: 1
Project status: SIGNED

This project will investigate the nexus between labour precariousness and authoritarian politics in Brazil, India, and the Philippines (BIP). At the beginning of the 2000s, emergent economies were promising global democratic powers. Yet, democratic consolidation faces significant challenges as BIP nations elect populist authoritarian politicians. The understanding of such a process remains fragmented or limited to a global North repertoire. This project proposes a framework that examines emerging economies’ development contradictions, namely economic growth that fostered new aspirational classes amidst labour precariousness. Several figures show that emerging classes supported authoritarian politicians in the BIPs. We interrogate why and how this occurs. A key problem in the scholarship on radical right supporters is to rely exclusively on reactionary emotions of anger, hate, resentment, and nostalgia in contexts of impoverishment and recession. In contexts of growth, reactive emotions must be understood alongside active drivers of aspirations and self-fulfilment stimulated by the entrepreneurial ideal. An innovative combination of intensive ethnography and extensive data sciences will analyse the ideological nexus between precarious platform workers’ and authoritarian politicians’ values in the BIP countries. Simultaneous 14-month ethnography in each country and data mining aim to scrutinise confluences and divergences between the two axes. This comparative research looks at how political subjectivity and aspirations are culturally and technologically shaped in different countries and platforms. The research team will explore two intertwined phenomena: (a) the sociological roots related to platform labour precariousness that makes this converge possible (sense of authenticity, isolation, individualism, competitiveness, entrepreneurial spirit), and (b) the technological infrastructure that promotes and reconfigures interactions between the two axes.

Keywords: far right brazil india philippines
Co-utilizing CO2 and metallurgical wastes for carbon-negative cement: science, technology, life-cycle impact assessment, end-of-life reuse, and process exploitation (CO2Slag Cement)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Finland,Switzerland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-08-31
End date: 2026-02-27
Duration (months): 30.0
Total project cost (EUR): 269418.0
EU funding (EUR): 269418.0
Participants: 3
Project status: CLOSED

Nearly 580 million tonnes per year (Mt/y) of ferrous metallurgical slags (FMS) are produced as by-products of iron, steel, and alloy production. The accelerated reaction of CO2 with Ca/Mg present in these FMS can result in the formation of Ca/Mg-carbonates, offering a relatively simple and low-energy pathway for CO2-abatement. This CO2-mineralization process has the capacity to directly sequestrate ~140 Mt-CO2/y globally, leading to the potential availability of ~720 Mt/y of carbonated-FMS as a by-product. The carbonated-FMS are expected to be rich in amorphous alumina-silica and Ca/Mg-carbonates: when used in combination with Ordinary Portland Cement (OPC), they are expected to form a composite cement similar to the presently marketed Limestone-pozzolana-OPC cement. In this context, this study focuses on the utilization of the carbonated-FMS to produce low-carbon cement with potential CO2-avoidance of ~500 Mt-CO2/y. To maximize the cementitious reactivity, the carbonation mechanism will be studied using different types of FMS and synthetic analogues of the major Ca/Mg-rich minerals present in them. The CO2-mineralization process and environment will be optimized to maximize the cementitious reactivity of carbonated-FMS by controlling their phase compositions, microstructures, and morphologies. When introduced as supplementary cementitious material (SCM), its hydration reaction with OPC will be studied to maximize its utilization potential. For the final mortar/concrete products containing carbonated-FMS, the environmental leaching will be studied. Moreover, pathways for the end-of-life recycling of the product will be analyzed through cradle-to-cradle scenario analyses. Finally, for easy acceptance by the practitioners, the product will be subjected to detailed life-cycle analyses and environmental impact assessments.

Keywords: sustainable construction materials,co2 utilization,metallurgical waste utilization,cement,life cycle assessment,environmental impact assessment,metallurgical waste,sustainable development
Understanding the Importance of the Melanocortin 3 Receptor in Muscle Mass Accrual and Body Composition (IMMAc)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-18
End date: 2027-06-17
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

We are yet to understand how the body regulates muscle mass in response to nutrient sensing at a whole organism level. The loss of muscle mass occurs in a range of diseases, including cancer cachexia, in which mortality risk is substantially increased by muscle wasting. The melanocortin signalling system in the hypothalamus is a crucial node in energy and nutrient sensing, with growing evidence implicating the understudied melanocortin 3 receptor (MC3R) in the control of body composition and lean mass. To date, the influence of MC3R tone on muscle mass has only been studied in mice and humans lacking MC3R from conception. To understand MC3R action and the spatial and temporal relevance of the receptor in regulating muscle mass, using in vivo and ex vivo approaches, IMMAc will: 7. Determine the neuroendocrine effects of MC3R activity 8. Assess the role of a putatively critical MC3R sub-population in controlling body composition and muscle mass 9. Determine the importance of MC3R for muscle mass in a mature organism and the extent to which MC3R tone can be manipulated to therapeutically alter muscle mass in adulthood Neuroendocrine impacts of MC3R activation will be examined using ex vivo hypothalamic culture and in vivo. Neuron-specific deletion of MC3R will allow mechanistic understanding of MC3R action, and the physiological and functional consequences of MC3R activation on skeletal muscle will be assessed by examining physical activity and fibre functionality. IMMAc will provide understanding of mechanisms underlying control of muscle mass and body composition by a key central nervous system receptor. Moreover, this project will reveal the relevance of MC3R for muscle mass in adult life and explore the therapeutic potential of manipulating MC3R to address the global health challenges of muscle atrophy and obesity by increasing lean mass in cachexia and improving increasingly prevalent anti-obesity agents through preventing loss of functional muscle.
Heat in the driver’s seat: unlocking the full potential of pulsed photothermal catalysis (HEATPULSE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The climate catastrophe urgently calls for greening and intensifying chemical reactors. Most chemical reactors use catalysts to speed up reactions, but their operation at steady-state temperature impairs rate, selectivity, and energy efficiency. To go beyond these limitations, applying short heat pulses theoretically leads to >100× higher reaction yield, lower energy use, and a controlled product distribution. However, pulsed heating has remained out of reach because it is hard to heat catalysts selectively and fast enough. I break this paradigm and take control of dynamic thermo-catalysis by using light pulses and robust “plasmonic” materials that convert light to heat with nanoscale specificity. HEATPULSE comprises three work packages that tackle three challenges: (1) kinetics: modulate pulse timing for controlling reaction rate and selectivity, (2) localization: confine heat at thermal hotspots to boost energy efficiency, and (3) stability and performance: access high peak reaction rates by developing temperature-stable pulsed photocatalysts. Ground-breaking innovations: (1) Access to a normally unreachable reaction landscape, with dynamic tunability of catalyst activity and selectivity; (2) Thermal hotspots break the limit of nanoscale heating and reach 3× higher peak temperatures with exponentially enhanced rates; (3) Metal nitride nano-arrays integrated with single-atom catalysts grant thermal stability beyond 1000 °C. HEATPULSE represents a revolution in green reactor technology by shifting from burning fossil fuels to heat-pulsing with light, powered by renewables. The project will lead to the new field of “photocatalysis beyond the steady-state” at the crossroads of catalysis, nanophotonics, and materials science. With an accomplished track record in nanoscale light-driven chemistry, and as a pioneer in the field of pulsed catalysis at both experimental and theoretical level, I am uniquely suited to unlock the full potential of pulsed photothermal catal

Keywords: plasmonics,photocatalysis,materials science,alternative plasmonic materials,nanoscale heat transfer,pulsed lasers
Backscattering coherent Stokes Raman scattering (sCiSsoRS) for real-time cancer diagnostics (sCiSsoRS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2432705.0
EU funding (EUR): 2432705.0
Participants: 1
Project status: SIGNED

The gold-standard for cancer diagnosis is the pathological examination of Hematoxylin & Eosin (HE) stained tissue. Though well adopted worldwide for the coloration of large numbers of cancer sections, the classical HE-staining procedure is unable to provide a fast-feedback to surgeons within less than 30min. This latency compromises the efficiency and accuracy of any tumor resection with numerous negative impacts for the success of the surgery and patient’s health prospect. Recently, the chemical-bond-specific image contrast provided by stimulated Raman scattering (SRS) was shown to be suitable for the generation of HE-like images. However, the SRS signal fundamentally propagates forward and is absorbed in thick biopsies rending a SRS-based diagnosis impossible. Furthermore, the SRS imaging speed is still too slow for the real-time determination of cancer borders in large specimen. Here, I want to resolve these obstacles by combining the non-linear optical contrast Coherent Stokes Raman Scattering (CSRS) with high illumination angles. CSRS will permit for the HE-like image generation, but will direct the signal photons into the backward direction as a result of a unique momentum conservation law. Backward CSRS will allow for the investigation of thick cancer samples and will enable technical solutions to boost the imaging speed that were never an option before. Thus, the development of CSRS is not only a scientific breakthrough that circumvents the fundamental dogma of always forward scattered light but will provide HE-like images of thick samples as a real-time feedback to improve the success rate and time-efficiency of cancer surgery.

Keywords: coherent raman spectroscopy,coherent raman histology,wide field coherent raman microscopy,non linear multi focus microscopy
Producing novel non-plant biomass feedstocks and bio-based products through upcycling and the cascading use of brewery side-streams (CHEERS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Innovation actions
Countries involved: Spain,Switzerland,United Kingdom,Germany,Portugal
Call: Novel, non-plant biomass feedstocks for industrial applications (HORIZON-CL6-2021-CIRCBIO-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 7355347.0
EU funding (EUR): 5670152.13
Participants: 13
Project status: SIGNED

Biotechnology has the potential to reduce the impact of human activities in nature. By developing new bio-based production platforms towards a more efficient use of waste streams, a step forward in industrial circularity can be achieved. CHEERS is a new biorefinery concept, inspired on nature biodiversity (insect and microbial platforms), to sustainably and efficiently upgrade underused or waste side-streams such as bagasse, wastewater, CO2 and CH4 from bio-based industries into innovative bio-based products. CHEERS will help bio-based industries to improve their feedstock use efficiency and overall sustainability and competitiveness via upcycling and cascading use of biomass produced from their side-streams. CHEERS is developed as a modular solution where bio-based industries can configure their optimal combination by selecting among 5 novel biotechnological routes which generate 5 bio-based products for industrial applications, with attractive market opportunities: insect protein, disinfectant, microbial protein, ectoine and caproic acid. All value chains are based on new bioprocesses and/or innovative biofermentors combined with sustainable downstream processes, which will be validated at demo-scale at an industrial brewery. A min. 45% carbon footprint reduction will be achieved in each value chain. The evaluation of CHEERS impacts will consider go beyond the classic LCA and will cover broader impacts such as biodiversity and land use. The beer company MAHOU is project coordinator and exploitation leader jointly with 11 partners of 5 European countries, including technology suppliers, end-users and research entities. CHEERS will contribute to a “zero waste” biorefinery approach, fully aligned with the EU Green Deal, Circular Economy Action Plan and Bioeconomy Strategy, and foster the understanding of biotechnology-based value chains through the engagement of relevant actors, from small bio-based industries to consumers.

Keywords: insect farming,biogas valorisation,co2 bioconversion,ch4 bioconversion,greenhouse gas bioconversion,novel non plant biomass,industrial scale up,novel protein sources,bio based value
Determining the role of interfaces in hybrid nanosystems applied to photochemical water splitting (RIHWAS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

Elucidating the role of interfaces during photochemical processes (PCP) for hybrid nanomaterials (e.g., metal-semiconductor or metal-insulator-semiconductor; MS or MIS) is critical to boost the performances of photodevices, as well as improving our fundamental knowledge on those materials. Extensive efforts have been performed to design novel nanomaterials and to investigate their efficiencies to attain an affordable, sustainable and renewable solar-to-energy conversion. Despite those research achievements, the role of interfaces is highly controversial regardless of their significant effect on PCP. In this project, I will develop a new platform combining interferometric scattering and scanning electrochemical microscopies. This platform unlocks in operando measurements to investigate the different interfaces’ mechanisms at multiple scale (meso-, micro- and nanoscales). The project focuses a reference system (Au-Al2O3-TiO2) and a model reaction (water splitting) to create knowledge on (1) analytical methods for identifying physical/chemical interactions at local scale and (2) fundamental understandings on the role of interfaces in nanostructures. The obtained results will establish a rationale for nanomaterial design applied to solar-to-energy conversion field. The platform versatility enables the study of all kind of 2D materials applied to most of the PCP. My previous experiences demonstrate my ability to develop and establish new techniques/ methodologies to answer fundamental questions for the energy conversion field. The original skills and my current expertise polished through this project will become an invaluable asset for my future career and contributions in the scientific community as a leading expert in the to-be developed fields. The fellowship will enable me to develop meaningful collaborations around the world and establish myself as an independent researcher.

Keywords: electrochemistry,plasmonics,interferometric scattering microscopy,scanning electrochemical microscopy,hybrid nanomaterials,water splitting
A Novel Antibody-Drug Conjugate for Targeting Tumor-Associated Macrophages in Solid Tumors (TAM-ADaCT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-03-01
End date: 2025-08-31
Duration (months): 18.0
Total project cost (EUR): 214285.71
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The project is focused on the development of a groundbreaking Antibody-Drug Conjugate (ADC) specifically designed for macrophage depletion in the Tumor Microenvironment (TME). With a primary focus on breast cancer and solid tumors, this initiative represents a paradigm shift in cancer therapeutics. The presence of Tumor-Associated Macrophages (TAMs) in the TME has been identified as a significant factor in tumor progression and immune evasion. Our proposed ADC will directly target these macrophages, effectively depleting them and thereby creating a more favorable environment for tumor eradication. The primary objectives of this project are as follows: 1. To synthesise and optimise ADCs for specific targeting and depletion of TAMs in the TME. 2. To demonstrate the efficacy of the ADC in preclinical models, establishing its potential for human application. 3. To perform a thorough "freedom to operate" analysis, ensuring that the ADC technology does not infringe upon existing intellectual property rights. 4. To establish a detailed plan for the commercial development of this ADC, outlining steps for regulatory approval, manufacturing scalability, and market entry. By achieving these objectives, we aim to propel this project from the conceptual stage to a viable, commercialisable medical solution. The successful implementation of this ADC has the potential to revolutionise cancer treatment, offering a targeted approach that could significantly improve patient outcomes. The support of ERC Proof of Concept Grant will be pivotal in transitioning this transformative technology from the laboratory to the marketplace, ultimately changing the landscape of cancer therapeutics. The strategic positioning of Zelula Biopharma (Host Institution) as a spin-off of CIC bioGUNE adds substantial value to this project, leveraging a unique blend of resources, academic research excellence and entrepreneurial agility to accelerate the transition from lab to market.
Converting organic waste into sustainable bio-based components (Waste2BioComp)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Portugal,Germany,Spain,France,Italy,Switzerland
Call: Manufacturing technologies for bio-based materials (Made in Europe Partnership) (RIA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-06-01
End date: 2025-05-31
Duration (months): 36.0
Total project cost (EUR): 5861765.0
EU funding (EUR): 5861763.0
Participants: 14
Project status: SIGNED

Waste2BioComp project aims to demonstrate relevant scale production of bio-based products and materials, as alternatives to traditional materials with high environmental footprint, using innovative manufacturing technologies. The project integrates all stages in the bio-based products´ life cycle, starting from R&I activities regarding the sourcing of feedstocks for the development of bio-based precursors and intermediate materials, smart inkjet printing techniques, and smart manufacturing technologies for final products, and the final demonstrators, which will entail the production on a relevant scale of the following bio-based products: shoe sole materials with different hardness; three-layered shoe insoles; plastic films/packaging with different flexibilities; social face masks; fashion garments printed with bio-based inks; leather and textile shoes printed with bio-based inks; paper for packaging printed with bio-based inks. Waste2BioComp will also develop sustainability and toxicity assessments to the developed materials and products, as well as re-manufacturing and recycling approaches to ensure circularity by closing the material loop. Furthermore, the project will develop dedicated training activities to support the creation of a skilled workforce in biomaterial-based manufacturing sectors, particularly for the textile, footwear, and packaging activities. Therefore, Waste2BioComp will have a significative impact on the reduction of the use of fossil-based materials, not only in the approached three value chains (textiles, packaging, and footwear), which are highly resource and polluting intensive sectors, but also with potential for several other sectors and applications. The project will run for 36 months, and it will be constituted by 13 partners from France, Germany, Italy, Portugal, Spain, and Switzerland.

Keywords: biopolyesters bio based materials inkjet printing textiles plastic and paper packaging shoe soles shoe insoles re manufacturing