Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
INcreasing the InNOVation Management Capacity of SMEs in ISTanbul (INNOVIST 4.0)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Türkiye
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 257552.5
EU funding (EUR): 257552.0
Participants: 3
Project status: CLOSED

INNOVIST 4.0 aims to provide Key Account Management (KAM) services to beneficiaries of Horizon 2020’s SME Instrument, FTI and FET Open; and providing services for “Enhancing Innovation Management Capacity” (EIMC) to SMEs in the Istanbul region. The main objective of the project is to contribute to enhancing the competitiveness, growth and profitability of SMEs in the region by assessing their innovation management capacities, performing gap analyses, and developing and prioritizing actions to resolve problems and further improve their innovation outcomes. The innovation management capacity and performance of a company will be assessed by using tools in compliance with the CEN/TS 16555-1 standard (such as IMP3rove, AToMIC or smE-MPOWER). A total of 113 SMEs will be provided this service, 103 of them targeted for EIMC services (7-10 days long), and 10 reserved for KAM services. The consortium will devote 2,35 FTE for these services for the 2020-2021 period.

Keywords: innovation management,innovation management capacity,assessment tool,sme instrument,key account management,innovation strategy
Uptake of Solid Bioenergy in European Commercial Sectors (Industry, Trade, Agricultural and Service Sectors) – Bioenergy for Business (Bioenergy4Business)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Germany,Ukraine,Austria,Belgium,Bulgaria,Romania,Poland,Slovakia,Greece,Croatia,Finland,Netherlands,Denmark
Call: Market uptake of existing and emerging sustainable bioenergy (H2020-LCE-2014-3, 2014)
Start date: 2015-01-01
End date: 2017-08-31
Duration (months): 32.0
Total project cost (EUR): 1540713.75
EU funding (EUR): 1540713.75
Participants: 13
Project status: CLOSED

A consortium led by the Austrian Energy Agency (AEA) developed the project "Uptake of Solid Bioenergy in European Commercial Sectors (Industry, Trade, Agricultural and Service Sectors) – Bioenergy for Business" for the EU-Programme Horizon 2020’s Call 2014 (LCE14). The project partners include a combination of energy agencies, national biomass associations and research-oriented partners with specialized knowledge on biomass from Northern, Southern, Central and Eastern Europe (Finland, Denmark, the Netherlands, European Biomass Association (AEBIOM), Germany, Austria, Slovakia, Croatia, Greece, Poland, Romania, Bulgaria and Ukraine). The goal of this project is to support and promote the (partial) substitution of fossil fuels (coal, oil, gas) used for heating, by available bioenergy sources (industrial wastes, forest biomass, straw and other agricultural biomass) in the partner countries and beyond. In this context, the project will contribute to increase much-needed security of energy supply through lower dependence on fossil fuels from politically volatile sources. Target groups are, on the one hand, owners and operators of industrial heating plants (for private or district heating). On the other hand, actors who play an important role with regard to the value chain and to framework conditions crucial for the use of bioenergy heat will also be involved. Activities will be tailored to the needs of actors relevant to promising market segments in the industrial, commercial, services and agriculture sectors. Results of the project will include information about market potentials, capacity building/training, decision-support tools and communication activities targeted at relevant stakeholder, tools to support the careful assessment, planning and implementation of such projects, and dissemination of “best-practice” business models. Additionally, information about “best practice” support measures and policies will be made available.

Keywords: renewable heat,bioenergy for autoproducers,bioenergy for district heating,solid biomass,straw,pellets,wood chips,biomass supply,commercial sectors,business models,best practice policies
Atomic Resolution Structures of Mitochondrial Respiratory Chain Supercomplexes (RSC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 178156.8
EU funding (EUR): 178156.8
Participants: 1
Project status: CLOSED

The objectives of this proposal are to determine atomic-resolution structures of mammalian mitochondrial respiratory chain supercomplexes (RCSs) by single particle electron cryo-microscopy (cryo-EM). It has been shown that the large protein complexes of the inner mitochondrial membrane responsible for electron transport from NADH to molecular oxygen (complexes I, III and IV) associate to form three major RCSs: I/III2, III2/IV2 and I/III2/IV. Currently, the physiological role of the RSCs is controversial and poorly understood. Atomic-resolution structures of the RSCs will be essential for fully understanding their physiology. Presently I have generated a 15 Å cryo-EM density map for RCS I/III2/IV from ~10,000 particles purified from Ovis aries mitochondria. Our preliminary data show that in order to push the resolution we will need to improve both the biochemical preparation of the RCS particles as well as the cryo-EM grid preparation. This will be done through systematic biochemical characterisation of the RCSs in different non-disruptive detergents and systematic grid preparation varying grid type and blotting conditions. In addition to RCS I/III2/IV, the structure of RCS I/III2 will be determined. High-resolution cryo-EM data will be collected at the Vienna Biocenter using the FEI Polara 300 mV microscope with Gatan K2 direct electron detector. In order to fully compare the make-up of the different RCSs mass spectrometric analysis will be carried out on the purified samples by our collaborators at the Laboratory for Molecular Biology (LMB). My previous experience in the laboratory of Dr Roderick MacKinnon mainly focused on membrane protein structure determination by X-ray crystallography and NMR spectroscopy. The opportunity to work at the IST Austria with Dr Leonid Sazanov will allow me to learn state of the art cryo-EM techniques, which are positioned to be the future of atomic-resolution structure determination for large macromolecular assemblies.

Keywords: supercomplex,respirasome,single particle cryo em,mitochondria,bioenergetics
Movement restoration with Adaptive EEG And Immersive Neurofeedback (MoveAGAIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 178156.8
EU funding (EUR): 178156.8
Participants: 1
Project status: CLOSED

Despite very extensive efforts to help millions of people in the EU alone who seek therapy to improve motor function after a stroke, most stroke patients are left with lifelong motor disability. Recent work from our group and others has shown that new methods and devices that can noninvasively monitor and stimulate brain activity could substantially improve recovery. EEG data collected from portable electrode caps can detect each patient’s motor imagery and thereby influence multimodal feedback in real-time. This feedback may include virtual reality avatars, rewarding music or tones, functional electrical stimulation, and potentially even magnetic or electrical stimulation of motor areas of the cortex. This promising new research direction requires extensive collaboration across disciplines and sectors, and experienced researchers (ERs) with relevant experience. The MoveAGAIN project will explore new classifiers, experimental paradigms, and software in tandem with an existing commercial system to create a new system that will be used to collect data with stroke patients in two real-world settings. We will analyze the resulting data to develop new knowledge and contribute to improved tools that therapists and physicians can use with patients. MoveAGAIN includes extensive dissemination and communication activities to convey our project results to numerous audiences. The varied training activities will supplement the ER’s training-by-research to help prepare him for a high-impact career working across industrial, academic, and medical sectors.

Keywords: paired associative simulation,stroke rehabilitation,functional electrical stimulation,brain stimulation,brain computer interface
Characterizing gene regulation in single cells through integration of scRNA-seq and scATAC-seq data with generic multi-modal prior information (GReCS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-15
End date: 2023-11-14
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

The advent of single cell technologies has enabled the characterization of cell types and developmental processes. Observations from different cells allow one to identify underlying patterns at higher resolution than convoluted bulk data, and integration of different omics data can yield a more differentiated picture of mechanistic connections. In this proposal, Gene REgulatory Cell States (GReCS) from multi-modal data, I plan to develop a computational method that combines these aspects to generate insights into gene regulation at the level of single cells. Measurements of chromatin accessibility in single cells are becoming increasingly common. The method I propose to develop combines sc/sn-ATAC- and scRNA-sequencing data to characterize gene regulation. My approach will integrate and use transcriptomics and open chromatin data to filter comprehensive prior information about candidate interactions and predict cell-specific gene regulatory network versions using machine learning, while sparse single cell measurements are imputed using local cell similarities. In this way, rare measurements across cell types and a larger condition space for network inference can be exploited, using the natural potential of chromatin accessibility data as a filter to map interactions into a cell-specific context. A distinguishing feature of the proposed method is the characterization of local gene regulatory states, which allows the observation of continuous changes throughout a cell-cell similarity embedding. This will be useful to examine changes during cell differentiation and along gradients in spatial reconstructions, for example of embryonic development. The developed methods will be made available to the community as a computational toolkit to improve the characterization of gene regulation by combining different types of data.

Keywords: single cell data,computational method,multi modal data,gene regulatory network,chromatin accessibility
Establishment of a Neutrophil elastase Activity home test for the Better management and treatment of Lung Exacerbations (ENABLE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: United Kingdom
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Chronic obstructive airways disease (COPD) is a leading cause of death of increasing prevalence worldwide and is characterised by progressive airflow reduction, breathing difficulties and irreversible lung damage. Management of COPD varies extensively, with patients not receiving proactive disease management at greater risk of poorer outcomes. Routine measurement of an active protease (enzyme) biomarker called neutrophil elastase (NE) will empower clinicians and patients to adopt proactive approaches to disease management and treatment, reducing exacerbations and emergency hospital admissions. Our goal is therefore to develop a novel, simple to use ‘Point-of-Care’ (PoC) test that will improve patient outcome and reduce the clinical, societal and economic burdens associated with chronic respiratory disease (CRD). The activity of NE (NEa) in the airways is known to correlate with the severity of several CRDs such as COPD, cystic fibrosis (CF) and bronchiectasis, and importantly is highly predictive of infection and an early marker of exacerbation. Our novel device, NEATstikTM (Neutrophil Elastase Airways Test), will enable the rapid measurement of NEa at PoC and has been designed for home use (patient self-management) in mind, with a view to remote monitoring. It is expected that this test will help to improve patient management and outcome, with the ultimate goal of reducing the individual, European and global burden of COPD. This phase 1 proposal is to provide a feasibility assessment which will maximise the potential for success the clinical validation of NEATstikTM, a PoC device that will enable the proactive management of chronic respiratory diseases such as COPD.

Keywords: proteases,lateral flow device,point of care device,home test,patient monitoring,disease management,chronic obstructive pulmonary disease,chronic respiratory disease,connected health
A novel fast test for antibiotic susceptibility testing for Gram positive and Gram negative bacteria (FAST-bact)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Spain,Italy,Netherlands,Portugal,Portugal
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2016-1, 2016)
Start date: 2016-12-01
End date: 2021-05-31
Duration (months): 54.0
Total project cost (EUR): 3675325.01
EU funding (EUR): 2655602.5
Participants: 7
Project status: CLOSED

In this project, the consortium will develop FAST-bact kits, a breakthrough test method to rapidly determine antibiotic drug susceptibility (AST), which will improve treatment of patients with serious bacterial infections. The current methodology in AST has a turnaround time of at least 24 hours, and up to 48 hours in case of blood cultures, whereas this novel flow cytometry-based test delivers results within 1-2 h. This will enable clinicians to start optimal antibiotic treatment as soon as possible, with a major impact on health and quality of life of patients and on health care costs. Resistance to antibiotic treatment leads to difficulties in the treatment of patients with bacterial infections. The FAST-bact project will have great impact on treatment of patients with (resistant) bacterial infections; a susceptibility report in useful time will reduce the use of broad spectrum or last line antibiotics. The FAST-bact tests will be marketed to clinical and microbiology diagnostic laboratories, in order to perform fast and accurate AST testing and optimize treatment for these patients. The tests will be marketed as a microplate-based kit, containing panels of antibiotics and compatible probes to determine the effect of the antibiotics, and including a software package for interpretation of results. The consortium will perform clinical validation of the tests against European and US standard methods. The previously designed decision support software, which allows fast and convenient result delivery, will be finalised and implemented. The technical file for regulatory proceedings will be drafted and large-scale production will be started. A commercialisation and dissemination plan will be drafted for market launch of the FAST-bact tests, first in Europe with expansion to other regions. In addition to these first products, opportunities will be explored to utilize the FAST-bact method for other tests, which will be included in the exploitation plan.

Keywords: antibiotic susceptibility,flow cytometry,bacteria
Dynamic sustainability assessment tool for the case studies of biorefinery supply chains from agricultural wastes (SABIR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

There is continuous refining and development of novel methodologies in the field of sustainability. From these methodologies, life cycle assessment is one of the most commonly used today. Over past decades researchers have “upgraded” life cycle assessment to life cycle sustainability assessment; later method combines 3 pillars of sustainability: environment, society and economy. While current methodologies looks at the impacts of analysed product or service in more holistic way, this approach is still lacking one important issue – dynamic feedback loops. The bottleneck of life cycle sustainability assessment method is rooted in the assumption that values for the impact categories remain constant, that is assuming a constant marginal impact or that no other sustainability information changes the overall system, and thus also the individual impacts. The aim of SABIR is to develop a novel, dynamic sustainability assessment tool, that uses life cycle sustainability assessment and system dynamic analysis tools at the same time in one model. To validate this tool two case studies of biorefinery supply chains from agricultural wastes will be used. Biorefinery case studies are chosen because these systems are increasingly seen as pivotal technologies to strengthen the growth in the area of bio-economy. Nevertheless, the overall environmental, economic and social consequences of implementing such biorefinery systems are poorly understood. Therefore, this project will aim to give two major benefits (1) to advance life cycle sustainability assessment methodology by introduction of feedback loops, (2) to advance studies on biorefinery concept, by outlining possible impacts and solutions.
Emission Control of Rare-Earth Nanoparticles (MONOCLE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2024-03-31
Duration (months): 36.0
Total project cost (EUR): 245732.16
EU funding (EUR): 245732.16
Participants: 2
Project status: SIGNED

Optical theranostic (diagnostic + therapy) techniques are low-cost, safe, and constitute a next big leap in the betterment of human healthcare. In that regard, luminescent nanoparticles (NPs) are poised to become the multifunctional instruments of personalized medicine. However, present-day theranostic NPs provide no control over their arsenal of capabilities – their competences are often entangled so that diagnostics cannot be done without therapy. In the same way that surgeons do not cut before ascertaining what and where to cut, so do light-responsive nanoparticles must have the flexibility to switch between their imaging/sensing and therapeutic modalities at-will. Rare-earth NPs (RENPs) are endowed with downshifting (Stokes) and upconversion (anti-Stokes) luminescence stimulated by near-infrared light; thus, RENPs are designed for non-invasive deep-tissue optical imaging (to diagnose) and in-situ mediation of photochemical processes (to treat). As such, RENPs are just the right candidates to decouple therapy from diagnostics, while preserving both in a single theranostic NP. With MONOCLE, I propose a tangible and timely development of RENPs with built-in control over their different emission modes. Capitalizing on the modular design of RENPs in unison with temporally modulated laser excitation, I intend to separate downshifting and upconversion processes creating truly-multifunctional theranostic RENPs (TMTs). In essence, TMTs are destined to apply “measure twice and cut once” philosophy – which constitutes benign examination and diagnosis of the target, with in-situ treatment available on-demand. Successful development of TMTs is projected to have far-reaching implications in safe and selective use of light-controlled nanomedicines. Furthermore, the multidisciplinary nature of this project is anticipated to foster new RENP architectures and alternative excitation pathways, decisively advancing not only biomedical but also luminescent materials science research.

Keywords: rare earth,upconversion,downshifting,theranostics,spectroscopy,near infrared