Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
UNDERSTANDING OPPORTUNISTIC SEAWEED HOLOBIONTS: HOW THE INTERACTION WITH THEIR MICROBIOME MODULATES THEIR METABOLOME? (HOLO-CWEED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

Global change is expected to increase the arrival of opportunistic macroalgae, as well as the rate and extent of blooming events, causing severe negative impacts on marine and coastal ecosystems. Opportunistic macroalgae may represent a particularly interesting source of secondary metabolites, as they adapt to highly variable environments and have a withstanding capacity to cope with environmental stressors. Valorization could be a key solution to transform this huge biomass of opportunistic species into a potential for biotechnological and socioeconomic innovation. Before this, it is crucial to have a full understanding on how seasons, life stage and environmental variability modify their metabolome and thus, the quality of their biomass. In this regard, the holobiont perspective (relationship of macroalgae with their microbiome) is paramount to understand comprehensively the macroalgal ecophysiology and the environmental factors modulating their metabolome, all along their life-cycle until their degradation. HOLO-CWEED aims to study opportunistic macroalgae as holobionts to: 1) shed light on the opportunistic macroalgal ecophysiology, 2) assess the intrinsic (microbiome) and extrinsic (environment) factors affecting the quality of their metabolome along their life-cycle, and 3) assess the impact of massive macroalgal strandings on the surrounding seawater. This work will require an inter-disciplinary methodological approach gathering microscopy, biochemistry, metabolomics and metabarcoding, to have a complete understanding of macroalgal holobionts. The host institution facilities and expertise will be essential for stepping from fundamental research to applied research through the valorisation of macroalgae. HOLO-CWEED provides an original scientific approach to understand how opportunistic macroalgae thrive in a changing environment and assess how their massive degradation changes the seawater quality.

Keywords: seaweed,holobiont,microbiome,bacteria,fungi,macroalgal blooms,coastal health,
Dissecting chromosomal instability in gastric cancer and its role in immunoediting using advanced functional and multiplexed single cell sequencing technologies (CINbyFUNseq)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Chromosomal instability (CIN) is a main cause of tumor heterogeneity, tumor evolution and therapy resistance of cancers. Chromosomally instable gastric cancer (CIN-gastric cancer) accounts for 50-70% of gastric tumors and is the poorest prognosis tumor subtype with the most suppressed tumor immune microenvironment. However, it is not understood how CIN contributes to poor prognosis and edits the tumor immune response of CIN-gastric cancer, due to a lack of assays investigating native CIN-driving mechanisms at the single cell level. I invented a pioneering, microscopy-based functional single cell sequencing method, which enables selective profiling of rare subpopulations of cells displaying dynamic phenotypes of interest. In this proposal, I will use my expertise to develop novel advanced single cell and multiplexed sequencing methods and create a new research line with the aim of dissecting the driving mechanisms of CIN in CIN-gastric cancer, investigating the impact of CIN on tumor microenvironment, and elucidating the molecular pathways leading to the poor prognosis of CIN-gastric cancer. To fulfill this aim, I defined three research objectives: In Objective I, I will develop a deep learning-based functional single cell sequencing (deepFUNseq) method to identify and profile rare, naturally occurring CIN-mother and -daughter cells derived from CIN-gastric cancer patients. In Objective II, I will develop a multiplexed functional & spatial single cell sequencing method(multi-FUNseq) to transcriptomically profile (non-)CIN gastric cancer cells and their interacting immune cells. In Objective III, I will investigate CIN-driving mechanisms and CIN-associated consequences in CIN-gastric cancer, including the role of CIN in immunoediting. The technologies developed in this proposal will result in a leap in our understanding of CIN in the context of cancer, and will lead to advances in fields where profiling cell-cell interactions is important, like tumor immunology.

Keywords: single cell technology,single cell sequencing,multi omics profiling,spatial transcriptomics,multiplexed sequencing
Developing high-energy tellurium/selenium redox-amphoteric conversion cathode chemistry for aqueous aluminum batteries (TSRA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-11-01
End date: 2026-10-31
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: SIGNED

Rechargeable aqueous aluminum battery (AAB) system is potential candidate for sustainable energy storage systems at a grid-scale, owing to their high safety, sustainability and low cost. However, the existing cathode chemistry (intercalation/deintercalation mechanism) exhibits poor kinetics caused by extremely high charge density of Al3+ ion due to the small ionic radius of Al3+ ion (0.39 Å versus 0.59 Å of Li+) and trivalent nature, leading to a restricted energy density and fast capacity fade. Those drawbacks hinder their extensive applications. In this project, we will aim to develop high-performance and innovative aqueous Al-Te and Al-Se batteries by creative redox-amphoteric conversion electrochemistry which means Te or Se will undergo positive and negative valance state during charging and discharging. To realize this goal, we will firstly screen the aqueous based electrolyte and create the appropriate electrolyte which can realize the redox-amphoteric conversion electrochemistry of Te and Se. And further we will explore the underlying specific mechanism of the whole electrochemistry by combining in-situ characterization technologies and molecular dynamics simulation. Moreover, the performance will be optimized by adjusting host materials, separator and anode. Finally, the device on pouch cell level will be demonstrated to clear as practical application. This project will enable the researcher to broaden her knowledge and have more comprehensive knowledge frame which is vital for her future career. Upon successful implementation of this project, due to the dual-ion charge storage mechanism and multi-electron transfer, the well-designed AAB could exhibit state-of-the-art performance among AABs and even approach the energy density of commercial lithium batteries. Meanwhile, this novel redox-amphoteric conversion electrochemistry will be an important extension of battery knowledge, and the proposed mechanism will be milestone in this direction.
In vitro and in situ structural characterization of the biofilm-associated functional amyloids in Pseudomonas aeruginosa bacteria (FAPbulous)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

Bacterial resistance to antibiotics poses a critical global threat and is partly due to the formation of stable biofilms which shield bacterial cells from antibiotics. Cystic fibrosis in lugs and some hospital-acquired infections caused by Pseudomonas aeruginosa are closely linked to the formation of biofilms and resistance mechanisms, which include the presence of amyloid fibrils. Amyloids are a class of proteins known for their ability to self-assemble into highly structured fibrils. Their pivotal role as major virulence factors in microbial pathogens makes them leading targets for developing novel antimicrobial treatments. However, our understanding of microbial amyloids is limited, especially in a physiological context. This gap is particularly pronounced for the Functional Amyloids in Pseudomonas (Faps). Detailed insights into their structures and how they interact within biofilms are still elusive, mostly due to the limits of imaging technologies. To address this knowledge gap, in the FAPbulous project, I will use a multidisciplinary approach by combining structural biology, biophysics and genetic engineering techniques to (1) determine the in vitro structures of Faps amyloid fibrils, (2) characterize their molecular mechanism within biofilms and (3) assess the effects of inhibitors known to prevent Faps fibrillation on biofilm formation and resilience. This highly innovative project will be achieved by using the recent advances in cryo-electron and super resolution fluorescence microscopies to gain unprecedented insights into the structural dynamics of Faps within medically relevant biofilms and unveil their detailed mechanism of action, paving the way for novel antimicrobial strategies. The interdisciplinarity of FAPbulous will massively improve my research profile, endowing me with the scientific and soft skills necessary to perform future multidisciplinary research at the interface of structural biology, host:pathogen interactions and protein aggregation.

Keywords: functional amyloid in pseudomonas,bacterial biofilm,cryo electron microscopy tomography,sub tomogram averaging,correlative light and electron microscopy,super resolution fluorescence microscopy
Wave: early detection of brain injuries in newborns by providing real-time AI analysis of EEG data (Wave)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

EEG is the gold standard for assessing brain injury at birth but remains underutilised mainly due to the scarcity of neurophysiologists who are required to read and interpret these unique and extremely complex neonatal EEG signals. As a result, an estimated 80% of hospitals lack EEG facilities, and even those with EEG capabilities often do not have 24/7 coverage. AI has allowed CergenX to completely reimagine how EEG technology can be used to help detect brain injury in newborns. Our mission is to safeguard newborn brain health by equipping clinicians with innovative, AI-driven assessment tools. Our vision is to make newborn brain screening a global standard of care, giving every baby the best possible start in life. Our flagship product, the Wave Device, part of our Wave Platform, leverages AI to quickly and accurately analyse EEG data, enabling early detection of brain injuries in newborns. Our complementary product to the Wave Device, WaveNet, an online viewer, enables neurologists and neurophysiologists to remotely access EEG recordings from the 15-minute assessment, enhancing treatment pathways and facilitating interhospital transfers. To address the challenge of the increased demand for comprehensive EEG evaluations and continuous EEG monitoring, which will place additional strain on neurophysiologists - resources that are already globally scarce - CergenX will develop WaveGen, based on Generative AI models, to automate EEG analysis and report creation. By streamlining these review processes, neurophysiologists can efficiently oversee more patients, ensuring timely and accurate assessments. Moreover, these GenAI-generated reports will provide detailed insights for neonatologists and paediatricians, facilitating prompt follow-up care, interventions and treatments for infants with identified brain injuries.

Keywords: brain injury,neonatal encephalopathy,neonatal encephalopathy,neurotechnology,eeg,electroencephalogram,generative ai
COORDINATED ACTION FOR RESPONSIVE MIXED ORCHESTRATION AND NETWORK YIELD (CARMONY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Innovation actions
Partnership: CCAM (co-programmed)
Countries involved: Austria,Spain,Sweden,Greece,France,Luxembourg
Call: Orchestration of heterogeneous actors in mixed traffic within the CCAM ecosystem (CCAM Partnership) (HORIZON-CL5-2024-D6-01, 2024)
Start date: 2025-05-01
End date: 2028-04-30
Duration (months): 36.0
Total project cost (EUR): 6506700.0
EU funding (EUR): 5991184.5
Participants: 12
Project status: SIGNED

The CARMONY project introduces an Interlinked Orchestration Framework for traffic management that integrates proven governance and business models, continuously refined using innovative simulation technologies with real-world traffic data. This approach aims to generate credible response plans, guidelines, and decision logics, fostering societal trust. Key stakeholders, including road operators, governments, and traffic managers, are involved from the project's inception, providing ongoing support. The framework is accessible via smartphone apps and online dashboards, aiding comprehensive traffic management decisions. It will be piloted in urban and highway areas in Spain and Luxembourg, focusing on enhancing traffic efficiency, safety, and sustainability, particularly in mixed traffic scenarios involving both manually driven and up to level 4 autonomous vehicles. Long-term simulations will demonstrate the system's impact, aiming to build trust among society and stakeholders. CARMONY anticipates significant improvements in traffic efficiency and sustainability, potentially reducing travel time and traffic jams by 10%, saving European society up to €10 billion and individuals 10-15 hours lifetime annually. In urban areas like Paris, it could reduce CO2 emissions by up to 280,000 tons annually. The CARMONY project aims to control traffic volumes via orchestrating individuals, based on optimizing traffic for everyone and focusing on individual requirements & needs, the orchestrator provides individual suggestions and leaves the final decision always to the human.

Keywords: traffic management and orchestration,decision support system,arbitration for safe,efficient and intelligent transport networks,proven business and governance models
High-Precision Continuous Polar Borehole Temperature Monitoring System (HIP-Bore)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-11-01
End date: 2027-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The Earth’s climate system is experiencing an accelerating energy imbalance, with unprecedented heat accumulation driving rapid transformations across the ocean, land, cryosphere, and atmosphere. Despite the critical need for high-precision subsurface ice and soil temperature measurements—to assess land energy storage1, reconstruct past climate evolution2,3, refine ice models4, and determine permafrost stability5 — existing solutions are either insufficiently precise, prohibitively expensive, or incapable of long-term operation in extreme environments. Based on my ERC SPACE research, we started to develop HIP-Bore, a system that delivers unmatched milli-kelvin long-term precision, operates reliably in the harshest conditions, and transmits long-term subsurface temperature data with minimal maintenance. No comparable solution exists today. By bridging a key technological gap, HIP-Bore is set to revolutionize environmental monitoring and advance climate science. Its ability to capture transient subsurface thermal data in previously unmonitored regions will unlock new insights into ice sheet stability, permafrost response to global warming, and the planet’s shifting energy balance. To bring HIP-Bore from research to real-world application, we seek funding to finalize development, assess market potential, and define a commercialization strategy. This project will drive technology transfer, positioning HIP-Bore for deployment. With its scalable, cost-effective design, HIP-Bore has strong market potential across research institutions, government agencies, and industries focused on environmental and infrastructure risk assessment. By delivering unprecedented insights into subsurface temperature changes, HIP-Bore can set a new standard in monitoring and play a pivotal role in mitigating and adapting to climate change.

Keywords: requested starting date 01 11 2025
Paleoepidemiology of infectious diseases across the Holocene EpidemioCene (EpidemioCene)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany,France
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-08-01
End date: 2031-07-31
Duration (months): 60.0
Total project cost (EUR): 1496506.0
EU funding (EUR): 1496506.0
Participants: 2
Project status: SIGNED

The frequency of infectious disease emergence has increased over the last decades, a phenomenon attributed to modern global sociodemographic and environmental changes. However, major transformations of human lifestyles and technologies associated with large-scale repercussions on the planet's ecosystems have occurred since prehistory. Measuring the epidemiological impacts of these changes on large time scales could provide precious lessons to anticipate the consequences of ongoing processes. Recent advances in the field of paleogenetics have opened promising perspectives in this regard by allowing the identification of various pathogens from skeletal remains dating back several millennia. The use of ancient DNA evidence for quantitative assessments of past disease distribution and determinants has, however, largely been missing so far. With this project, my group will leverage tens of thousands of ancient DNA libraries and sequencing datasets produced during recent years at the host and partner institutions to undertake large-scale paleoepidemiological investigations covering the past 12,000 years of human history in western Eurasia. Novel laboratory, bioinformatic and statistical approaches will be developed to maximize pathogen detection sensitivity and estimate variations in disease frequency from ancient metagenomic data while accounting for expected sources of biases. This will be combined with epidemiological modelling and phylodynamic analyses of large sets of ancient pathogen genomes to unveil paleoepidemiological dynamics and their associations with sociocultural transitions and environmental changes throughout the Holocene. This project will provide unprecedented insights into the inseparable history of humans and their pathogens, a multi-millennial perspective on current global health challenges, and strong foundations for future paleoepidemiological studies.
Flexibly adjustable mobility, energy, industry, and governance innovations to improve decarbonisation of periurban areas and accelerate their integration in the transition towards climate neutrality (periASTY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Climate neutral and smart cities
Destination: Climate neutral and smart cities
Action type: Innovation actions
Countries involved: Belgium,Cyprus,Greece,Netherlands,Ireland,Spain,France,Finland,Portugal,Slovenia,Switzerland,Bulgaria
Call: Integrated peri-urban areas in the transition towards climate neutrality (HORIZON-MISS-2024-CIT-01, 2024)
Start date: 2026-01-01
End date: 2028-12-31
Duration (months): 36.0
Total project cost (EUR): 10334120.89
EU funding (EUR): 9239025.75
Participants: 36
Project status: SIGNED

periASTY envisions fostering the integration of peri-urban areas’ transition towards climate neutrality by advancing and developing mobility, energy, industry, and governance-related net zero technologies and business models. A suite of innovations, the periInnovations, is designed to host technological and non-technological solutions. The periInnovations suite offers four groups of innovations: 1. periMOBILITY aims to reduce car dependency in peri-urban areas (active modes, multimodality, mobility services); 2. periENERGY concentrates efforts on reducing emissions and promoting sustainable energy sources (energy system demand, energy charging hubs, renewable local energy communities); 3. periINDUSTRY focuses on reducing GHG emissions, improving efficiency in industrial operations, and promoting a circular economy and reuse (urban mining, circular economy, local green deals, waste management); 4. periGOVERNANCE supports governance, planning, and decision-making (governance framework for functional urban areas (FUA) digital twins, AI-based data warehouse) and builds capacity among local authorities and stakeholders on implementing climate-neutral concepts, integrated planning, and attracting investments/funding (periSKILLS Academy). The periInnovations are integrated into real-life mobility, energy, and industry services, operations, and infrastructure, allowing the demonstration of the co-designed concepts in nine diverse Living Labs across peri-urban areas: Dublin, Limassol, Ljubljana, Marseille, Guimarães, Helmond, Kalamata, Sofia, and Sisslerfeld (Switzerland). periASTY is more than just a consortium; it is a transformative, Europe-wide initiative dedicated to accelerating the transition of peri-urban areas towards climate neutrality. By integrating sustainable mobility, energy, and industrial solutions, periASTY directly supports the objectives of the Green Deal, Mission Climate-Neutral, Smart Cities, and other EU partnerships for 2030.

Keywords: periinnovations,perimobility,perienergy,periindustry,perigovernance