Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deciding about Future Science: How Scientists Can Collectively Set Research Priorities in the Era of Big Science (DECIDE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-07-01
End date: 2031-06-30
Duration (months): 60.0
Total project cost (EUR): 1439198.0
EU funding (EUR): 1439198.0
Participants: 1
Project status: SIGNED

Since World War II, we have entered the era of ‘big science’. Experiments in the natural sciences today can involve hundreds or thousands of scientists, they generate enormous amounts of empirical data and they require ever larger instruments. The associated cost of experiments has unsurprisingly also soared. Personal research funds or smaller research grants no longer suffice to fund certain experiments; instead, they require significant financial support from multiple government agencies over a long period of time. Because of this increase in costs, scientists have had to change how they decide what experiments to pursue. The central research question of this project is therefore: how can scientists make optimal decisions about what future experiments to pursue, given the scale of experiments and the limited available resources? To answer this research question, the project will follow the approach of integrated history and philosophy of science. Through a careful study of the history of one of the most influential procedures for scientific funding decisions, the US Astronomy Decadal Survey, this project will: (i) trace the origins of current procedures for collective decision-making in science; (ii) investigate how these procedures have impacted the development of scientific research, specifically on the post-World War II history of astronomy, astrophysics and cosmology; (iii) formulate a novel philosophical account on what makes an experiment pursuitworthy; and (iv) apply current insights from social epistemology on collective knowledge-making and values and science to a new context, collective setting of research priorities. Aside from its impact in history and philosophy of science, this project will have implications for the natural sciences by recommending revisions to current strategies for the setting of future research priorities. More broadly, this project will establish the nascent discipline of philosophy of astronomy and astrophysics in Europe.

Keywords: integrated history and philosophy of science,history and philosophy of astronomy,astrophysics,and cosmology,social epistemology,philosophy of experiment
Ecological Entanglements and Biodiversity in Late Medieval Northern Europe, 1400-1600 (ECOLENT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-10-01
End date: 2031-09-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

ECOLENT develops a new conceptual-methodological framework to study the impact of ecological entanglements, interconnections between different regions, on biodiversity in a historical context. It will do so by using the late medieval Hanseatic League as a case study. This merchant association bought food products and raw materials in Scandinavia and the Baltic, and exchanged them for manufactured goods in the urbanised Low Countries and England. In this way, they created both economic and ecological connections between different regions of Northern Europe. Humans' modification of ecosystems in one part of the trade network can only be understood by considering it in tandem with interventions in the network's other regions. The project studies the impact of the socio-economic pressures the Hanseatic trade network generated on animal and plant diversity in six regions (Flanders, Guelders, Schleswig, Brunswick-Lüneburg, East Prussia, and Kraków) from 1400 to 1600. It thus draws attention to the history of biodiversity, a subject that has been overlooked in both historical and archaeological studies so far, but whose study has become particularly urgent in the context of current ecological challenges. The methodology developed on the basis of the Hanseatic League's exceptionally rich source material — historical and archaeological — can later be adapted to examine biodiversity in other geographical and chronological contexts. Many scholars have analysed humans' relationship with nature, but none have placed relationships within animal and plant communities at the centre of attention. The main focus has always been on their use as trade commodities. The project proposes a new interpretation of non-human agency that acknowledges both animals' and plants' capacity to respond to environmental stimuli. They did not remain passive towards human attempts to commodify the natural world, even though only few of them were truly agents in their own right. This is their story.

Keywords: biodiversity,animals,plants,hanseatic league,medieval history,environmental history,historical ecology,environmental archaeology,human animal relations,ecological conservation
BIOmimetic selective extraction MEMbranes (BIOMEM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Denmark,France,Finland,United Kingdom,Portugal
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-04-01
End date: 2027-03-31
Duration (months): 36.0
Total project cost (EUR): 2598493.0
EU funding (EUR): 2598493.0
Participants: 7
Project status: SIGNED

The ability to selectively extract compounds from waters will transform a multitude of applications, ranging from high-value compound isolation in industrial bioprocesses to removal of pollutants from the environment. However, current filtration technologies are reliant on physicochemical separation strategies requiring high pressure/energy inputs and cannot discriminate specific molecules. BIOMEM will develop novel biomimetic membranes harnessing the unique selectivity of biological transport proteins to facilitate the extraction of single compounds with exquisite specificity. Our concept is to use the unique antiport characteristics of secondary active transport proteins, to move molecules, even at low concentrations, across a polymer membrane against their concentration gradient, deriving energy from the transport of another readily available ion down its own concentration gradient. A novel group of bifunctional polymers will be used to extract membrane proteins, together with their associated lipids, into nanoscale discs. These will then be embedded into polymer membranes which are otherwise impermeable to create membranes that are completely selective for the compound of interest. These bio-inspired membranes will be characterised to understand organisation and function of the membrane, to allow design and optimisation for custom compounds. The produced membranes will be tested for functionality in a proof-of-concept experiment to extract complex high-value oligosaccharides from bulk biomass and phosphate from wastewaters. While initially focussing on those two applications, the separation technology developed will evidence the potential for “plug and play”, bespoke, selective membranes capable of transporting specific molecules through existing or bio-engineered transporters. The developed membranes will be fully scalable and operate at rates comparable to state-of-the-art nanofiltration devices, while simultaneously requiring around 50-75% less energy.

Keywords: membrane transporter proeins,membranes,polymers,filtration,bioprocessing,circular economy,pollutant removal
The first effective and safe reversal agent to stop or prevent life-threatening bleeding in patients taking the emerging generation of anticoagulants. (StopBleeding)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-09-01
End date: 2025-03-31
Duration (months): 31.0
Total project cost (EUR): 4842087.5
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

50 Million patients worldwide use oral anticoagulants to prevent venous thrombosis and stroke. Since the last decade, unpredictable and risky indirect anticoagulant treatments are being replaced by the latest generation of blood-thinning medication: Factor Xa Direct Oral Anticoagulants (FXa-DOACs, used by >10 million patients in EU+US). With superior predictability, efficacy and safety profiles, these life-saving medications remain associated with a risk of uncontrolled and severe bleeding. Alarmingly, there is no safe reversal agent that restores blood clotting in patients who take FXa-DOACs, resulting in life-threatening bleeding episodes and >400k hospital admissions. To address the urgent unmet need, VarmX has developed VMX-C001, the first effective and safe reversal agent to FXa-DOACs. VarmX requests a €2,5M in grant and €15M in equity EIC to accelerate upscaling and improve the cost-effectiveness of the complex manufacturing process required to produce VMX-C001.

Keywords: health related biotechnology,emergency medicine,biotechnology,blood clotting,recombinant protein,reversal agent,emergency care,antidote,bleeding,biologics,anticoagulants,medicine,coagulation,critical care
NURturing transformative capacities, Innovation in NBS and Harmonious resilience in rural areas (NURISH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: Greece,Germany,United Kingdom,Netherlands,Spain,Italy,Cyprus,Finland,Malta
Call: Demonstration of solutions specifically suited to rural areas and small/ medium size population local communities (HORIZON-MISS-2024-CLIMA-01, 2024)
Start date: 2025-10-01
End date: 2030-03-31
Duration (months): 54.0
Total project cost (EUR): 8039877.5
EU funding (EUR): 7492688.75
Participants: 27
Project status: SIGNED

NURISH aims to enhance climate resilience and sustainable development in rural and small urban communities by implementing transformative nature-based, technological and circular economy solutions. It supports the EU’s long-term vision for stronger, connected, resilient, and prosperous rural areas by 2040, contributing to territorial cohesion, innovation, job creation, skills development, better infrastructure and sustainable agriculture. The project will develop the Regenerative Rural Resilience Framework to help rural areas mitigate climate risks through nature-based solutions (NBS), fostering entrepreneurship and creating green jobs. Resilience Hubs (RHs) in Greece, Cyprus, Finland and the UK will demonstrate tailored NBS to address flooding, water scarcity and land degradation, while digital tools will support real-time monitoring and decision-making. Communities in the demonstration and replication areas will actively participate in the EU Rural Pact, promoting rural perspectives, fostering collaboration and advancing nature restoration and conservation through NBS. By sharing knowledge and scaling solutions across rural regions, NURISH ensures its strategies are adaptable and replicable throughout Europe, contributing to the EU Green Deal, the Climate Adaptation Strategy and rural prosperity goals by 2040.

Keywords: regenerative rural resilience circularity co creation capacity building community engagement nature based economy digital transition knowledge transfer climate risk assessment
Advancing Trans-Regional Border Studies (Eur-Asian Border Lab)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Estonia,Finland,Netherlands
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2022-11-01
End date: 2025-10-31
Duration (months): 36.0
Total project cost (EUR): 1493690.0
EU funding (EUR): 1493690.0
Participants: 3
Project status: SIGNED

The project positions Tallinn University (TLU) to become a leading institutional and intellectual platform for scholarly exchange on border studies, in partnership with the University of Eastern Finland (UEF) and the University of Amsterdam (UvA). The uniquely designed Eur-Asian Border Lab, to be established and anchored at TLU, will become a platform that catalyses trans-regional conversations and synergies between the Euro-American and Asian border scholars, and addresses the contrast between bordering as an increasingly complicated conceptual process and the more straightforward policy-oriented approaches to borders. The Eur-Asian Border Lab through its online and offline activities will investigate bordering across the increasingly volumetric and virtual spaces, cross-fertilize research findings and reach out to practitioners, policymakers and the public. TLU’s vanguard position in advancing a trans-regional and multi-layered approach to understanding key social, political and environmental issues through bordering is expected to boost its scientific excellence, enhance its institutional capacity to administer research and improve access to new research collaborations. The partners, complementing each other in their strengths and research foci, will contribute key expertise and professional networks for knowledge mobilization, while engaging actively in the joint research activities, capacity building and attracting early career researchers.

Keywords: boundary,borderlands,bordering processes,mobilities,migration,trans regional,eurasia
The chemical warfare between sponge and coral species informing reef restoration in Pacific Island communities in Papau New Guinea (CIRCLE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland,Papua New Guinea
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 252728.64
EU funding (EUR): 252728.64
Participants: 2
Project status: SIGNED

Human activity is predicted to result in a 1.5-4 ºC global warming of air temperature by 2100. The globally averaged ocean surface temperature data shows a mean warming trend of 0.062 ºC/decade since 1900. Since 2010 this has increased to 0.280 ºC/decade. The loss of coral species is decreasing the competitive sponge species chemically fighting for space. Given the imminent threat that global warming has on the future of coral reefs, there is a strong need for robust scientific measures of reef health and future sustainability to improve the survival potential of corals and better inform reef restoration projects, ensuring healthy, diverse, and resilient coral reefs. CIRCLE (ChemIcal waRfare in CoraL rEefs) aims to investigate the influence of climate change on the chemical warfare that occurs in coral reef ecosystems between sponge and coral species, to inform conservation efforts to protect reef ecosystems. We hypothesize that the increasing ocean temperatures are influencing the diversity and distribution of sponge and coral species, where a trade-off is being made between survival and growth. This research will develop critical information for understanding the chemistry and genetic variations required for reef ecosystem growth and (re)-building in response to climate change. It will improve our understanding of future economic and social impacts of global warming on Pacific Island reef ecosystems. CIRCLE will advance the current state of the art application of multi omics techniques to explore the interspecies chemical ecology between sponge and coral species. Through the combined use of omic techniques and chemical natural product experiments we will identify biochemical markers of coral and sponge health. The knowledge gained in this project will empower local Pacific Island communities to enact procedures to monitor and protect the reef and ocean environment, protecting social and economic prosperity.

Keywords: marine natural products,sponge,coral reef,chemical ecology,restoration,allelopathy
Molecular bases of zinc-mediated immunity in Arabidopsis thaliana (ZINMUNITY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Recent studies have shown that plants locally increase zinc concentrations to fend-off invading microbes, a process in which Zn2+- ATPases HMA2 and HMA4 are essential. ZINMUNITY aims to unveil the molecular mechanisms controlling plant-zinc based immunity, connect it to the known defence signalling pathways, and determine the mechanisms allowing HMA2 and HMA4 to locally increase zinc levels. To do this, I will be trained in the patho-system Arabidopsis thaliana-Plectosphaerella cucumerina BMM, in metal imaging, confocal microscopy, transcriptomic and proteomic data analyses, and biochemistry of Zn2+-ATPases. In exchange, I will contribute with my experience in protein-protein interaction and in computational analyses of protein docking. At the end of this project, I should not only have placed zinc-toxicity mechanisms within the general plant immune responses, but also identified the molecular patterns triggering it, and determined the identity of the zinc-donor proteins to HMA2 and HMA4, impacting both the plant immunity and nutrition areas. As relevant will be setting the foundations for the development of new strategies of crop protection based on the use of zinc enriched bio-estimulants or fertilizers, with important societal (reduction of polluting/toxic and expensive pesticides), and economical implications (lower costs for farmers, new markets for the zinc-fertilizer industry). Moreover, this proposal will set the basis for me to reach a position of scientific independence, since ZINMUNITY will deliver a number of interesting genes for future characterization. This next career step will also be facilitated by many of the transferable skills acquired, such as grant applications, paper publication, research supervision and FAIR data management.

Keywords: zinc transport plant defence plant immunity plant pathogen zinc homeostasis plant pathogen interactions
EXPanding AAV gene therapy by EDITing (EXPEDITE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 2492303.0
EU funding (EUR): 2492303.0
Participants: 4
Project status: SIGNED

In vivo gene therapy based on a single administration of adeno-associated viral (AAV) vectors is emerging as an effective therapeutic option for both monogenic and complex diseases. Given the episomal nature of the AAV genome, its applications are limited to non-replicating tissues like retina or adult liver. Several AAV-based products that target these tissues are either approved or in advanced clinical development. Despite this, some limitations still remain, including: the potential for insertional mutagenesis associated with genome-wide AAV integration; the loss of transgene expression from replicating tissues like newborn liver; and the challenge to counteract toxic gain-of-function mutations, which cause dominant diseases for which canonical gene replacement is ineffective. EXPEDITE aims to integrate therapeutic DNA at desired genomic loci safely and effectively, thus overcoming the above limitations. EXPEDITE will go beyond the current state-of-the-art by implementing and comparing two parallel strategies: (i) novel Cas fusion proteins to recruit DNA repair machineries at induced double stand breaks (DSBs) to maximize on-target donor DNA integration; (ii) novel cleavage-free platforms for therapeutic DNA integration, based on transposases or bacterial single strand-DNA annealing proteins. The therapeutic relevance of these platforms will be tested in the retina and liver, two highly relevant tissues for gene therapy, using animal models of inherited retinal degenerations and lysosomal storage diseases, respectively, and, ultimately, non human primates. To reduce the risk of potential off-targets, EXPEDITE will also test non-viral vectors for transient delivery of the genome editing tools while delivering the donor DNA via AAV. The results from EXPEDITE will allow significant expansion of the patient population that can benefit from in vivo gene therapy and may represent a change of paradigm for gene therapy by replacing canonical gene addition approaches.

Keywords: gene therapy,adeno associated viral vectors,aav,genome editing,liver,retina