Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Holistic framework for the MatUrity evaLuaTIon of ReAdiness level for security TEchnologies (MultiRATE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Strengthened Security Research and Innovation
Action type: Research and Innovation actions
Countries involved: Greece,Spain,Sweden,United Kingdom,Finland,Netherlands,Germany,Portugal,Italy,France
Call: A maturity assessment framework for security technologies (HORIZON-CL3-2021-SSRI-01, 2021)
Start date: 2022-12-01
End date: 2025-05-31
Duration (months): 30.0
Total project cost (EUR): 1389252.5
EU funding (EUR): 1389252.5
Participants: 15
Project status: CLOSED

In the recent years, there are plenty of metrics that try to evaluate the maturity of products/systems/processes when identifying their deployment readiness. Even though, an excessive effort has been made to integrate widely used frameworks, methodologies and indicators in the products/systems/processes, this leads to a limited usage from the EU funded security R&I projects. As a result, a robust scaling framework is more than of utmost importance. The proposed MultiRATE scaling framework will rely on the existing established readiness level approaches and will formally combine them into one acceptable and reliable framework. MultiRATE will be able to evaluate and apply the readiness of all aspects of products/systems/processes. It will make a thorough research on the existing methodologies and will develop a well-established scale taking into consideration several areas of knowledge such as Technology Readiness Level (TRL) scale, Integration Readiness Level (IRL), Commercialisation Readiness Level (CRL), Manufacturing Readiness Levels (MRL), Security, Privacy and Ethics Readiness Level (SPRL) and Societal Readiness Level (SRL). These RLs will set the basis for the creation of the holistic MultiRATE framework that will evaluate the readiness of all aspects of a product/system/process. The experience gained from previously proposed and ongoing maturity evaluation solutions developed and will be proposed under EU-funded projects will lead to the MultiRATE robust holistic framework solution. Of great importance will be the establishment of a network of projects and organisations that will support the design of the appropriate evaluation methodologies adding also their knowledge and expertise on the calibration and testing of both individual RLs and the holistic one. This network will be built based on the partner’s involvement on existing networks and EU funded projects.

Keywords: trl,societal rl,security rl,lperl,irl,crl,mrl,holistic rl
Contributions of muscle mechanics and sensorimotor control to agile locomotion (AgileSim)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: CLOSED

Humans and animals navigate complex terrain seemingly effortless. This is in stark contrast with even the most performant robots, illustrating that walking over complex terrains is by no means trivial. Our neuromusculoskeletal system is equipped with mechanisms that allow us to recover from unexpected perturbations. Two key mechanisms are muscle intrinsic mechanics and sensory-driven feedback control. Immediate changes in muscle force upon a perturbation allow the body to respond fast to sudden perturbations through quick-acting muscle mechanical responses. Feedback responses, slower due to transmission delays, are also critical to stability as they are more flexible whereas muscle mechanical responses are determined by feedforward control and muscle properties. We do not yet know how these pathways interact to help us maintain agility and robustness, in the presence of external perturbations, or in the case of sensory loss. I aim to gain novel insights into how muscle mechanics and sensory feedback allow agile locomotion across conditions. I will unravel fundamental principles governing relative contributions of these mechanisms, using a blended experimental- and computational approach. I already collected a unique experimental dataset that I will combine with physics-based simulations. I will use novel approaches to predict locomotion patterns and feedforward and feedback control by optimizing performance criteria in presence of sensorimotor noise without relying on experimental data. Validation of simulation to experimental data allows us to evaluate which performance criteria and muscle properties drive observed interactions between muscle mechanics tuned by feedforward and feedback control. As many neurological disorders impair stable locomotion, fundamental insights obtained through my project have potential to inform treatments. Lastly, novel insights in locomotor neuromechanics inspires designs of legged robots and prosthetics to assist during locomotion.

Keywords: neuromusculoskletal modeling,stochastic optimal control,muscle mechanics,sensory feedback,terrain navigation,neuromechanics
Exploring the contribution of hypothalamic gliosis to the metabolic and reproductive complications of hypogonadism: Translational implications for obesity-induced male hypogonadism. (GLIA-ReprObesity)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 285140.64
EU funding (EUR): 285140.64
Participants: 2
Project status: SIGNED

Obesity is a worldwide epidemic and a serious public health threat since it greatly increases the risk of highly morbid chronic diseases, including type 2 diabetes, hypertension, cardiovascular disease, and many cancers. A growing body of literature has suggested that obesity is associated with hypogonadism, (defined in males as low levels of endogenous testosterone) a reproductive disorder that substantially elevates metabolic risk. The mechanisms linking reproductive function to metabolism are not fully understood, but emerging evidence from clinical and preclinical studies suggests the potential role of hypothalamic gliosis. Recent data support a model in which microglia (brain macrophages) and astrocytes mediate the effects of a Western-type diet to induce obesity, and that hypogonadism synergizes with an obesogenic diet to profoundly activate hypothalamic gliosis. In this context, we propose a multidisciplinary approach to unveil the potential role of hypothalamic gliosis as a central node linking metabolic dysregulation and reproductive dysfunction. The studies described herein will use astrocyte- and microglia-specific mouse models of increased or reduced inflammatory signaling to determine whether gliosis is proximal to hypogonadism, hypogonadism causes gliosis, or they establish a vicious cycle together. These studies will potentially provide cellular targets for new therapies to offset the long-term metabolic harm from hypogonadism and to improve reproductive function in obese patients. Beyond its translational value, the project will provide a solid foundation for the scientific career of the fellow and help her achieve the long-term goal of becoming an independent scientist.

Keywords: reproductive health,obesity,hypogonadism,astrocytes,microglia,kiss1
Highly functional and chemically defined hybrid supramolecular hydrogels for organoid culture and multi-technology bioprinting (HYBRIGEL) (HYBRIGEL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

There is a growing need for reproducible, human-relevant in vitro models to advance biomedical research and drug discovery. Current 3D culture systems often fail to replicate the complexity of native tissues, contributing to poor clinical translation rates and limiting the development of animal-free testing platforms. While organoid technologies and biofabrication methods offer promising solutions, their progress is constrained by the lack of standardized, scalable biomaterials. Widely used matrices such as Matrigel, derived from laminin-rich tumor extracts, suffer from batch variability, undefined composition, and poor compatibility with advanced manufacturing techniques. Building on my ERC-funded VOLUME-BIO project, we have developed HYBRIGEL, a novel, chemically-defined hydrogel designed to address these limitations. HYBRIGEL is based on abundantly available gelatin, modified with reversible supramolecular interactions in addition to covalent crosslinking. This creates a dynamic, cell-responsive environment that promotes tissue remodeling, cell migration, and mechanotransduction—without requiring additional bioactive peptides. HYBRIGEL supports diverse cell types, including organoids, mesenchymal stem cells, vascular cells, and T cells. HYBRIGEL’s enhanced mechanical stability allows for the creation of complex, biomimetic structures through biofabrication techniques such as volumetric bioprinting. Its reproducibility, scalability, and manufacturing efficiency position it as a strong candidate for widespread adoption in both research and pharmaceutical applications. This project will advance HYBRIGEL towards commercial exploitation by expanding its validation across multiple organoid types and demonstrating scalable production processes. A comprehensive market analysis will inform the commercialization strategy, with an envisioned focus on licensing the technology to established industry partners.
Environmental stressors as causal determinants for immune-mediated diseases – mapping and prioritising evidence for knowledge-based policy making (EXPOSIM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Living and working in a health promoting environment
Action type: Research and Innovation actions
Countries involved: Belgium,Norway,Denmark,Portugal,Spain,Switzerland,Poland
Call: The role of environmental pollution in non-communicable diseases: air, noise and light and hazardous waste pollution (HORIZON-HLTH-2024-ENVHLTH-02-two-stage, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 8176741.01
EU funding (EUR): 7998991.01
Participants: 10
Project status: SIGNED

In a large majority of non-communicable diseases (NCDs), including the immune-mediated diseases (IMDs), complex gene-environmental interactions contribute to the onset and development of disease through the modulation of biological pathways. IMDs are characterized by abnormal immune responses, have limited therapeutic options and require lifelong treatment if not detected during the preclinical stage. EXPOSIM will provide a strong evidence base to better understand the impact of combined environmental stressors on immune health, with a focus on air pollution, noise and hazardous waste in urban areas. More specifically, we will investigate the impact of environmental stressors – the external exposome – on IMDs and immune health at different stages in life (pregnancy, childhood and adulthood). We will identify biological pathways and molecular mechanisms mediating the effect of combined exposures on IMDs. Through case studies and topical reviews, we will demonstrate the effectiveness of exposure-reducing and health-promoting interventions, with a focus on vulnerable and highly exposed individuals. This knowledge will be translated into policy recommendations and informed decision-support tools. Moreover, the project emphasises on scientific collaborations and stakeholder engagement, involving co-creation of health-promoting actions, education, training and communication. EXPOSIM will build a user-friendly toolbox for regional, national and EU policymakers, health professionals, researchers and citizens. To reach its ambitious objectives, EXPOSIM brings together a geographically balanced, experienced interdisciplinary consortium (active in PARC, EXIMIOUS, EHEN, METEOR) of ten European partners with complementary expertise in exposome research, epidemiology, immunology, omics, novel data analytics, health economics and social sciences and humanities. Ultimately, EXPOSIM will contribute to a healthy environment and healthy lives for all EU citizens.

Keywords: autoimmune diseases,immune mediated diseases,exposome
Solidarity Lost in Implementation? Social Mobility and Belief in Meritocracy Shaped by School Choice Policies. (EDUMERIT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Estonia
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1494660.0
EU funding (EUR): 1494660.0
Participants: 1
Project status: SIGNED

Educational choices shape futures, influence life chances, and are among the most significant factors in social mobility. Despite political and academic consensus on avoiding early selection, inequalities in educational opportunities are on the rise, even in systems that aim for equity or discourage parental choice. Paradoxically, the belief that today’s educational opportunities are meritocratically earned is growing, reducing the demand for inclusive education. EDUMERIT aims to explain the policy feedback of school choice implementation by revealing its contextually embedded effects on parental experiences and fairness beliefs. It shows how varying exposure to educational selectivity and political-social constraints, shaped by stakeholders' discretion and discourses, result in discrepancies between real and perceived outcomes, as well as related fairness judgements. It breaks through the state of the art in studying policy feedback effects in shifting the focus from policy design to policy implementation, and from broader popular attitudes to parental fairness reasoning in school choice. It offers a bold new conceptualization to define under which conditions feedback effects in education result in the rising meritocracy beliefs at the expense of re-distributional demand. It sets out a comparative nested empirical design to reveal parental school choice experiences and related fairness reasoning by combining cross-European evidence with survey experiments, qualitative interpretive interviews and social media analysis in Estonia, Poland, and Sweden. EDUMERIT innovates by addressing endogeneity in education policy feedback effects and advancing a relational approach to fairness reasoning. It develops the role of ‘forward-looking’ social mobility in the broader fairness debate, elucidating inequalities that matter. It strengthens the policy and politics of inclusive education by enhancing the compatibility between meritocracy and solidarity of welfare policies.

Keywords: policy feedback effects,fairness beliefs,meritocracy,education,policy implementation,school choice policy,social mobility,survey experiment,qualitative interpretive interviews,social media analysis,welfare mix
Predictive ApproacHes fOr SafEr UrBan Environments (PHOEBE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Countries involved: Greece,Netherlands,Germany,Slovenia,United Kingdom,Spain,Belgium
Call: Predictive safety assessment framework and safer urban environment for vulnerable road users (HORIZON-CL5-2022-D6-01, 2022)
Start date: 2022-11-01
End date: 2026-07-31
Duration (months): 45.0
Total project cost (EUR): 3368933.75
EU funding (EUR): 3368933.75
Participants: 11
Project status: SIGNED

Safer urban environments are needed for all road users to ensure the European targets to halve road deaths and injuries by 2030 are met. Vulnerable road users require specific attention in an urban environment that is subject to constant change as new forms of transport and micro-mobility enter the system. Existing traffic simulation models allow changes in traffic conditions to be tested but are often vehicle and travel time focused and do not measure detailed outcomes specific to vulnerable road users and road safety. City administrations and transport managers will benefit from predictive tools that allow these changes and their implications for road safety, mobility, and sustainable transport to be anticipated, and support the associated policy, regulatory and consumer response. The Predictive Approaches for Safer Urban Environments project (PHOEBE) will move beyond the state of the art and deliver an interdisciplinary solution that will integrate traffic simulation, road safety assessment, human behaviour, mode shift and induced demand modelling and new and emerging mobility and telematics data into a harmonised, prospective assessment framework for road safety. New conditions and mobility solutions will be able to be assessed and safe system solutions tested. The PHOEBE framework, software module and knowledge products will allow dynamic safety prediction and socioeconomic evaluation that is evidence-based and simulates future scenarios and impacts. Simple and effective visualisation and socioeconomic modelling will provide the confidence for policy decisions and investment. City administrations across EU will be consulted as the framework is developed and deployed. The feasibility of the framework will be demonstrated in three use cases in Athens (GR), Valencia (ES) and West Midlands (UK), which have been selected to maximise the use of existing base traffic models, potential impact and to ensure the future scalability and transferability of the solution.

Keywords: area a,predictive safety assessment framework,traffic simulation,road safety assessment,human behaviour,mode shift and induced demand,mobility data,vrus,socio economic analysis
Strategies to modulate the bioavailability of cannabinoids in edible products: in vitro tests, cytotoxicity, and pre-clinical assessment to generate reliable data for regulatory agencies (CBDHIGHBIO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Portugal,Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-17
End date: 2025-05-16
Duration (months): 31.0
Total project cost (EUR): 172618.56
EU funding (EUR): 172618.56
Participants: 2
Project status: CLOSED

Cannabis edibles (CE) are considered a big opportunity to take place in the recent and fast-growing cannabis market. However, there are big challenges on the development of these products, such as the lack of understanding of the metabolism of cannabinoids after oral ingestion, the low bioavailability of cannabinoids (including cannabidiol, CBD), and high intra- and inter-subjects’ pharmacokinetic variability. Recent approaches to enhance the oral CBD bioavailability include its incorporation into lipid-based delivery systems and the addition of compounds called bioenhancers. Lipids can enhance the oral CBD bioavailability via an increase in the transport to the systemic circulation via intestinal lymph, whereas bioenhancers may inhibit metabolizing enzymes reducing the extent of its liver first-pass effect. Piperine (PIP) is known as a powerful bioenhancer by inhibiting drug-metabolizing enzymes of cytochrome P-450 (CYP450), that are involved in the CBD metabolism. The aims of this study are to provide reliable data about the CBD metabolism after oral ingestion to help regulatory agencies to regulate the market of CE and standardize the consumption indications for these products; to increase the CBD bioavailability by using long-chain fatty acids to promote the enhancement of lymphatic absorption combined with PIP addition to inhibit the hepatic metabolism of CBD; and develop an advanced delivery carrier to enable its vehiculation into aqueous-based CE. We hypothesize that the combination of CBD and PIP can substantially improve the CBD bioavailability, thus decreasing the intra- and inter-subject variability. Systematic in vitro tests will be performed to evaluate the inhibitory effect of PIP on CYP450 activity, to determine the bioaccessibility, stability and bioavailability of CBD and PIP after oral ingestion, and to assess their cytotoxicity. Finally, in vivo studies will be performed to evaluate the CBD pharmacokinetic and bioavailability.

Keywords: cannabis edibles,delivery systems,nanoestructures,cannabinoids,bioavailability,bioenhancers,nanocarriers,in vitro digestion,pharmacokinetics,functional food,cytotoxicity