Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Digital Copy of the Earth (Nomoko)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

NomokoAG is a fresh start-up based in Switzerland whose innovation has received public recognition right from the beginning. Besides, the company entered “TOP100, The Best Swiss Start-ups in 2016”, received the 2016 ZKB Pionierpreis, than was elected among the “10 venture leaders in Technology 2017” and grew to be the “25th best Start-up of 2017 in Switzerland”. We provide solutions to automatically create “Artificial Reality”. With a strong belief that volumetric city-based 3D data is the future, we bring innovation to the digital mapping market, where accuracy is still a constraint for the development of several applications. Even if expecting to reach € 7.17 billion by 2025, the market is looking for alternatives able to raise the precision of digital maps at a cost-effective price. In this context, we offer a digital copy of the Earth – a platform where you can build digital solutions and products that are rooted in “reality”. Nomoko is a cloud based engine turning the world from a static model to a dynamic one thanks to a real-world based, ultra-accurate and efficiently developed 3D model environment extracted from very high-resolution imagery acquired with in-house developed technology (1 Giga pixel digital camera coupled to a drone). Built as a web platform with a graphical user interface, Nomoko enables the integration of additional data about contextual information to semantically enhance the 3D model (using machine learning algorithms to perform object classification and highlighting elements like: house, traffic sign, composing materials) and link information to an object for further analytics. We propose a Platform as a Service approach enabling partnerships in view of client based tailored services generation. This project will provide us the right means and support for further commercialization of our product and confirm our financial projections of € 45.5 million accumulate revenues and an 18.65 return of investment.

Keywords: drone,digital mapping,simulation,autonomous vehicles
Next generation robotic surgery: robotic vision based safe endoscopic spine surgery (X-BONECUT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-11-01
End date: 2022-04-30
Duration (months): 30.0
Total project cost (EUR): 3098377.0
EU funding (EUR): 2103193.4
Participants: 1
Project status: CLOSED

All surgical robotic solutions available in the market today are precise manipulators rather than robots, as none of them takes its own decisions nor does automatize any process. For surgical robotics to make the next paradigm change, the ability for the robots to take their own decisions must be developed. To take their own decisions, they need to be aware of the environment where they are working. In other words: they need to have robotic eyes. This is exactly what Deneb Medical (DM) is developing with its X Platform. This surgical robotic platform approach enables multiple market applications, for which Deneb Medical has defined a product pipeline. The first product in this pipeline is DM’s X-BoneCut. Today the most important surgical problem, is the elimination of surgical unintended damage. DM’s X-BoneCut will be a surgical robot tailored to perform endoscopic lumbar surgeries in a safe and fast way, eliminating the risk of surgical unintended damage to duramater (incidental durotomy) and nerves, reducing overall surgery time and with an easy learning curve. X-BoneCut will add to private and public health institutions up to 7B$ in value in EU and US, as it will help reduce total average direct costs to hospitals in 7B$. DM’s business model is based on the development, manufacturing and sale of the robot and its disposable. The revenue model includes the sale to the distributor of a) the robotic system b) the disposable needed to perform surgeries with it and c) the robot’s maintenance contract. DM’s strategy is to install a big number of robots and supply the disposables, so the revenue portion of the disposable will increase throughout the years. X-BoneCut is based on a DM’s already patented technology and DM knows no competitor that is developing a similar device with a similar functionality. Further DM is working on 3 additional patent applications that will help create stronger competitive advantages, not only for the short but also for the longer term.

Keywords: smart surgery system,robotic surgical platform,endoscopic spine surgery,realtime tissue identification,selective ablation of bone tissue,incidental durotomy
Helping marketing campaigns go viral (Demographica)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Switzerland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Marketers want to create buzz, but it’s not always so easy. For a marketing message to spread like wildfire, not only does it have to reach the target audience, but it also has to be well-timed and well-placed. SThAR has developed algorithms that improve the chances of getting it right. The Ecole Polytechnique Federale de Lausanne spin-off developed DEMOGRAPHICA software capable of identifying where and when to deliver a message most effectively and create buzz both on traditional (offline) and online media such as social media. The software developed by the start-up offers both geographic and temporal targeting for electoral and advertising campaigns. The ideal times and places are not necessarily remarkable in terms of the number of people directly reached, but these people are connected to others, who are in turn connected to others. The resulting dynamic increases the message’s impact. DEMOGRAPHICA allows to scale the execution of F2F campaigns improving the impact and reducing the costs. The challenge for DEMOGRAPHICA is to become the tool for optimizing and managing face-to-face (F2F) street campaign reducing the cost while increasing the impact. The main commercial objective is to achieve the 15% of the European fundraising market (11.5M € revenue) in 3 years at a 0,3% fee.

Keywords: campaign,marketing,big data,real time schedules,algorithms
Automated Anode Fork Repair System for the Aluminium Rodding Plant (Auto-Anode)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Iceland
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Worn out anode forks from aggressive alumina smelting conditions require efficient repair processes since they contribute around 16% of the heat lost during electrolysis. Currently, most of the repair is handled manually, giving room for human error, inconsistencies and high labour costs. There is also a high carbon footprint from the manual propane cutting and transportation of forks to a distant rodding plant. The concept of our project, Auto-Anode, hinges on integrating automated anode repair modules, and at least doubling the speed, accuracy, efficiency, safety and accountability of the process. It will eliminate propane use and the need to transport forks to a separate workshop, thereby reducing the carbon footprint by ca 48t CO2 pa. Automation for the various stages has largely been validated. The challenge lies now in ruggedising the machine vision and integrating the system. Undoubtedly, a properly integrated Auto-Anode system will be a game changer for the aluminium smelters, with yearly savings of up to €30 per ton of produced aluminium, and for our company, generating an accumulated net profit of €21.65 million by 2024. Besides compound savings by smelters, Europe could save up to €4.5million from potential imports of aluminium and give an edge in the lightweight automotive race, while cutting on greenhouse emissions. Imminently, SMEs within the value chain can enjoy increased profitability since the price of locally produced aluminium will be lower. Global savings of up €13million pa are possible due to the use of Auto-Anode. To ensure a widespread uptake of this advanced process technology, beyond assuring technical, seamless excellence, we will carry out a detailed market study; conduct a technology watch and IPR strategy; consolidate supply chain partners; detail the exploitation and dissemination plan and finally elucidate the overall business plan.

Keywords: alumina reduction,smelters,electrolysis,anode fork,automatic,repair,rodding plant,energy efficiency
NMDA receptor diversity: from molecular dynamics to synaptic physiopathology (NMDADYN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-11-01
End date: 2022-10-31
Duration (months): 72.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

NMDA receptors (NMDARs) have long fascinated neuroscientists with their distinct biophysical properties and critical roles in neuronal communication and plasticity. Recent studies have revealed that these glutamate-gated ion channels are more complex than initially thought, undergoing tight subunit-specific regulation by an array of endogenous modulators and existing as multiple subtypes, each with its own anatomical, functional and signaling properties. Such complexity raises key questions regarding the conformational changes that this multi-domain receptor undergoes, the physiological relevance of its subunit plurality and the microenvironment’s impact on receptor and circuit function. To address these challenges, this project uses innovative strategies at the crossroads of protein engineering, biological chemistry and neuroscience to achieve a molecular level control of NMDARs that is subunit-specific, reversible and usable both in vitro and in vivo. Using a bottom-up approach, it contains four aims covering molecular, cellular and behavioral levels. The first two investigate NMDAR structural mechanisms and exploit this knowledge to develop new optochemical receptor tools. The next two address physiological questions using these tools as well as original biosensors and novel mouse lines. Aim 1: Characterize NMDAR conformational dynamics and allosteric transitions Aim 2: Engineer a family of light-controlled NMDARs (‘Opto-allostery’) Aim 3: Understand the role of specific NMDAR populations in neuronal functions Aim 4: Explore the receptor’s synaptic microenvironment in normal and disease states This multi-scale project creates and implements the spatially and temporally sensitive tools required to break the barriers to our understanding of NMDAR diversity and modulation. The results will provide fundamental insights into the intricate workings of an essential class of brain receptors and further our comprehension of neuronal excitatory transmission and pathology.

Keywords: glutamate receptors,synapses,neurotransmission,optopharmacology,protein engineering
HUmins as Green and Sustainable precursors of eco-friendly building blocks and materials (HUGS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Germany,France,France,France,Netherlands,Netherlands
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EID) (H2020-MSCA-ITN-2015, 2015)
Start date: 2015-11-01
End date: 2019-10-31
Duration (months): 48.0
Total project cost (EUR): 1274464.26
EU funding (EUR): 1274464.26
Participants: 8
Project status: CLOSED

The HUGS concept ( HUmins as Green and Sustainable precursors of eco-friendly materials and biofuels) discloses an integrated multidisciplinary EID proposal with involvement of high-tech SME’s two research centers and 3 world class universities in the area of biorefinery. All partners have been chosen by their complementary expertise and their extensive experience in supervising PhD programs and coordinating international scientific projects. The proposed methodology and approach focuses on side-stream valorization of FDCA/PEF polyester production process developed by Avantium. HUGS aims to provide breakthrough knowledge combined with an excelling training program on humin by-products by implementing work packages which will respectively focus on side streams to building blocks; building blocks to composites; safety and toxicity aspects; training and dissemination activities and management, communication and public engagement. 5 PhD are envisaged to be recruited to reach these ambitious goals with regards to multidisciplinary training and beyond stateof-the-art research. Each PhD will be seconded at the company as well as between the collaborating universities aiming to develop a number of essential leadership, entrepreneurial, communication and scientific skills in program fellows. All partners will organize week-long dedicated training courses in their field of expertise (homo- & heterogeneous catalysis, physico-chemical polymer analyses, toxicity and safety, IPR, techno-economic evaluation) over the total duration of the project. The proposed research is novel and highly original which will justify scientific publications in top-ranked journals together with a unique training program. PEF is unique in being the first technical superior and 100% biobased plastic to come to the market. The HUGS project as being closely linked to PEF commercialization which it will guarantee maximal exploitation of the results, communication and public engagement.

Keywords: humin,furfuryl alcohol,methyl levulinate,levulinic acid,acrylic acid,composite,resins,biobased,economy,polyester,side streams,value added,high tech
Epigenetic Profiling of Chemotherapy Efficacy (EPOCH28)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2015-11-01
End date: 2017-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The aim of this proposal is to showcase that chromatin regulators represent a novel class of biomarkers that can predict the response to individual drugs. The proof of concept will be established by validating our recent discovery of a 28-gene signature of chromatin regulators that predicts the response of 26 out of 31 patient-derived xenograft breast cancer models to docetaxel. Notably, in patients treated with docetaxel, though all are subjected to toxic side effects, less than half of them clinically benefit, and no test exists to predict response. In the context of our funded ERC project, discoveries in our team underscored the key role of several chromatin regulators in establishing and maintaining chromatin landmarks, such as centromeres. In particular, our recent work demonstrated that mislocalization of the centromeric histone variant CenH3 gives cells an adaptive advantage to overcome DNA damage induced by camptothecin treatment and gamma irradiation. Further, preliminary evidence from our lab and others has highlighted a link between the expression level of chromatin regulators, including those involved in centromeres, and docetaxel sensitivity in a cellular context. Based on these promising studies, there are three aspects that we wish to develop as proof of concept for the use of chromatin regulators as novel predictive biomarkers for docetaxel treatment. First, we wish to further illustrate our chromatin regulators as a predictive signature for docetaxel treatment. For this, we will test samples from patients having received neoadjuvant docetaxel treatment alone. Secondly, we will test the applicability of our method in other cancers and drugs through an established collaboration with Roche to predict vemurafenib efficacy in melanoma. Thirdly, we will further evaluate the market need for predictive signatures for other commercial oncology drugs, and a potential spin-off that derives companion diagnostics for new drugs in clinical trails.

Keywords: docetaxel,biomarkers,chromatin dynamics,breast cancer,companion diagnostics,precision medicine,personalized medicine
Innovative mobile “continuous food mixer” to improve the sustainable use of raw materials and the quality of the products (SANSO V2.0)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Sweden
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Herman Anderssons Plåt AB (HAPAB) is a Swedish SME that works as a supplier and innovation partner for small, medium and large companies in various industries. With the present project, SANSO V2.0, the company will complete the development and industrialization of an innovative and automatic mobile continuous system to improve the traditional mixing processes in the food industry. Mixing technology has not been practically innovated over the years, and with SANSO V2.0 we will revolutionize the market through consistent resource-efficiency, and achieving high quality final products. Thanks to its homogeneous and continuous process, it will result in completely free of lumps products, with a perfect texture, and with significant savings in raw material utilisation (4 % - 6 %) and in energy consumption (22.5 % per kilo of dough). This raw materials and energy savings imply a price reduction of about a 30 %. SANSO V2.0 project objective is to scale up current pilot system in order to industrialise this innovative resource-efficient system bringing it to commercial stage by 2020. SANSO V2.0 is based on an innovative small chambers' system which allows the continuous mixing process increasing the contact between the different ingredients. It is an easily customizable system that can be adapted to different kind of products within the food industry. SANSO V2.0 is so unique that some customers even consider replacing or add on to their current solution before its end of life. This system will reduce operation time and costs, allowing HAPAB to intensify notably its international presence and to increase its revenues. The payback for the estimated investment in this project will be reached during the third year of commercialization of the new system.

Keywords: mixing,stand mixers,bakery industry,mixing process,raw material efficiency,continuous system,food industry
Form and Function of the Mitochondrial Retrograde Response (FIRM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: United Kingdom,United Kingdom
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-04-01
End date: 2026-03-31
Duration (months): 84.0
Total project cost (EUR): 1450060.0
EU funding (EUR): 878105.75
Participants: 2
Project status: SIGNED

The molecular communication between mitochondria and nucleus is an integrated bi-directional crosstalk - anterograde (nucleus to mitochondria) and retrograde (mitochondria to nucleus) signalling pathways. The mitochondrial retrograde response (MRR) is driven by defective mitochondrial function, which increases cytosolic reactive oxygen species (ROS) and Ca2+. Metabolic reprogramming is a key feature in highly proliferative cells to meet the energy needs for rapid growth by generating substrates for cellular biogenesis. In these mitochondria retro-communicate with the nucleus to induce wide-ranging cytoprotective effects exploited to develop resistance against treatment and sustain uncontrolled growth. Recently, the mitochondrial management of cholesterol-derived intermediates for the synthesis of steroids has been demonstrated as a determinant in the oncogenic reprogramming of cellular environment. We hypothesise that cholesterol-enriched domains facilitate the communication between remodelled mitochondria and nucleus to expedite MRR. This mechanism may be exploited during abnormal cell growth in which cholesterol metabolism and associated molecules are increased. This application capitalizes on expertise in cell signalling and metabolism to interrogate core pathways and unveil molecular sensors and effectors that define form and function of the MRR by: I. Elucidating the mechanism of metabolic regulation of MRR, describing the role exerted by cholesterol trafficking; II. Unveiling microdomains for mito-nuclear communication established by remodelled, autophagy escaped, mitochondria; III. Validating protocols to modulate and target MRR for diagnostic and therapeutic benefit; The experimental plan will (i) define a molecular signalling axis that currently stands uncharacterized, (ii) provide mechanistic knowledge for preventive, and (iii) therapeutic applications to counteract deficiencies associated with stressed, dysregulated mitochondria.

Keywords: mitochondria,inter organelles communication