Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Improving Subsidence PREdictions in Delta systems (InSPiRED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-01
End date: 2022-10-02
Duration (months): 18.0
Total project cost (EUR): 137604.96
EU funding (EUR): 137604.96
Participants: 1
Project status: CLOSED

Almost 500 million people live in river deltas, which host among the most important areas for economic activities and global food production on the planet. Relative sea-level rise (RSLR) in delta systems is predominantly caused by land subsidence and accelerating subsidence rates threaten the future existence of these low-lying landforms, including their inhabitants, environment and economy. Reliable projections of future RSLR are urgently needed to prospect the fate of sinking delta systems but their creation is presently hampered by our inability to accurately resolve delayed subsidence. This causes uncertainties in subsidence rate projections potentially much larger than climate-change driven rates of sea-level rise. The InSPiRED (Improving Subsidence PREdictions in Delta systems) project aims to improve our ability to quantify delayed subsidence by upgrading a novel, physics-based numerical simulator and to develop a generic integrated approach at create accurate RSLR projections for sinking coastal-deltaic areas. These will facilitate the design of effective management strategies for local delta policymakers. The approach will be designed for different temporal and spatial scales, ranging from decennial to millennial and from a single marsh to an entire delta, respectively, in three major delta systems, the Po, Mississippi, and Mekong deltas. Both the applicant and the research group have strong track records of cutting-edge subsidence research with different disciplinary backgrounds. The applicant will bring geomorphological and geological knowledge to the research group, leading in geomechanical engineering and numerical modelling. This will enable the inter- and multidisciplinary research required for this project and facilitate transfer of ideas. The project will strengthen the applicant numerical and geomechanical skills and reinforce his research competencies and professional networks, enhancing his career development as an independent researcher.

Keywords: land subsidence,relative sea level rise,deltas and coastal plains,geology,geomorphology,delta evolution,hydrogeology,numerical modeling,mitigation and adaptation strategies
Science Engagement to Empower Disadvantaged adoleScents (SEEDS)

Framework: Horizon 2020 — Science with and for Society
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Greece,Netherlands,United Kingdom
Call: Bottom-up approach to build SwafS knowledge base (H2020-SwafS-2020-1, 2020)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 1099502.5
EU funding (EUR): 1099502.5
Participants: 6
Project status: SIGNED

Adolescents at risk and living in deprived areas have fewer opportunities for out of school activities, informal learning and reduced access to science education. In addition, teenagers seem to have, in general, a lack of interest in Science. Besides, research showed how the social determinants of health, and specifically, deprivation and lower access to health information, have major consequences in terms of chronic diseases. Scientific literacy can be promoted through enhancing health education: health research is well-valued in the society; topics are practical and relevant, and it is important to change unhealthy habits as early as possible; self-leadership and active methods would be key ingredients. There is a need for evidence and validation of effective interventions for fostering science education and public participation with teenagers and young adults from vulnerable and/or deprived populations to raise their academic outputs, while contributing to improve empowerment in health for this group. SEEDS aims at fostering science literacy and STEM education by raising the health understanding, also pursuing the empowerment of youth in critical thinking skills, self-management and self-care through community-based public engagement, therefore improving effectiveness of health promotion interventions in this population. The multi-stakeholder participatory intervention merges the dialogue between citizen science and traditional science. SEEDS joins together the key players in science and society by applying the 4Helix model of stakeholders. Teenagers lead the process; the scientific literacy will be accompanied by a depth health education able to transform their habits, contributing to sustainable behavioural change.

Keywords: citizens science,stem,health inequalities,social determinants of health,education inequalities
ELITRANS-Facilitating the transformation of ELI from ERDF funded, distributed infrastructures towards a unified ELI-ERIC. (ELITRANS)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Belgium,Hungary,Romania,Czechia,Netherlands,United Kingdom
Call: Individual implementation and operation of ESFRI projects (H2020-INFRADEV-1-2015-1, 2015)
Start date: 2015-09-01
End date: 2019-02-28
Duration (months): 42.0
Total project cost (EUR): 3395383.75
EU funding (EUR): 3395383.0
Participants: 10
Project status: CLOSED

While the implementation of the “Extreme Light Infrastructure” ELI is nearing completion in Czech Republic, Hungary and Romania, its remaining goal is to create the necessary conditions for the future operation as a single, distributed international laser user facility of pan-European dimension. The scope of the present ELITRANS project is to complement the final implementation stage by preparing and undertaking the transformation from three legally (but not conceptually) independent construction projects towards operation as a single international legal entity, ELI-ERIC. The main objectives are: • Conceptual Design of the future ELI-ERIC’s “Business Model”: essential elements of the future ELI-ERIC organization, financing, governance and international integration • Preparing ELI-ERIC’s “Business Plan”: development of concepts adapted to the operation as the world’s first international laser user facility • Managing the transition from Structural Funds supported implementation towards ERIC-funded operation: merging the three facilities into one unified internal structure, developing a corporate identity, strengthening user relations, developing the scientific profile, international visibility and leadership The proposed actions are structured in eleven Work Packages. They cover the majority of activities considered necessary by the Commission for a successful implementation of ESFRI projects, and take into account specific recommendations by the ESFRI Assessment Expert Group. The objectives shall be achieved through concepts jointly developed with European and international partner facilities, and world-leading e-infrastructures.

Keywords: international laser user facility,extreme light infrastructure,structural funds,eric,new member states
MYRRHA Research and Transmutation Endeavour (MYRTE)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Fission/fusion cross-cutting actions
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Italy,Spain,Spain,Germany,Italy,Italy,Germany,Belgium,Belgium,Belgium,Switzerland,Switzerland,Slovenia,Belgium,France,France,France,France,Netherlands,Portugal
Call: Transmutation of minor actinides (Towards industrial application) (NFRP-2014-2015, 2014)
Start date: 2015-04-01
End date: 2019-09-30
Duration (months): 54.0
Total project cost (EUR): 11994609.99
EU funding (EUR): 8995962.0
Participants: 35
Project status: CLOSED

The Strategic Research Agenda of the EU Sustainable Nuclear Energy Technical platform requires new large infrastructures for its successful deployment. MYRRHA has been identified as a long term supporting research facility for all ESNII systems and as such put in the high-priority list of ESFRI. The goal of MYRTE is to perform the necessary research in order to demonstrate the feasibility of transmutation of high-level waste at industrial scale through the development of the MYRRHA research facility. Within MYRRHA as a large research facility, the demonstration of the technological performance of transmutation will be combined with the use for the production of radio-isotopes and as a material testing for nuclear fission and fusion applications. Numerical studies and experimental facilities are foreseen to reach this goal. Besides coordination, international collaboration and dissemination activities, the MYRTE proposal contains 5 technical work packages. The first and largest work-package is devoted to the realisation of the injector part of the MYRRHA accelerator to demonstrate the feasibility and required reliability of this non-semi-conducting part of the accelerator. The second work-package addresses the main outstanding technical issues in thermal hydraulics by numerical simulations and experimental validation. Pool thermal hydraulics and thermal hydraulics of the fuel assembly will be the focus of this WP. In the WP on LBE Chemistry, the evaporation from LBE, capture and deposition of Po and fission products will be studied in detail to complement the safety report. A small dedicated WP on experimental reactor physics is also foreseen to allow carrying out the necessary supplementary experiments at the GUINEVERE-facility to address the questions of the safety authorities. In a last WP, advanced studies on Americium-bearing oxide fuel are carried out to demonstrate the capability of developing minor actinide fuel for transmutation.

Keywords: snetp,reactor physics,accelerator driven system,transmutation,myrrha
Risky Decisions: Revealing Economic Behaviour (RDRECON)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-12-31
Duration (months): 68.0
Total project cost (EUR): 1461881.0
EU funding (EUR): 1461881.0
Participants: 1
Project status: CLOSED

Households are exposed to a wide array of monetary and non-monetary risks: employment risk, financial risk, interest rate risk, and health and mortality risk, to name a few. Society and policymakers can certainly help households manage risk, but to be effective, they need to understand the ways households cope with risk and how vulnerable they are to market and policy changes. For instance, how do households react to bank defaults and market failures? How personal do these experiences have to be for households to change behavior? And how permanent are the changes in behavior? The goal of the proposed research program is to understand how personal and market experiences affect financial decisions made by households, such as savings behavior, portfolio allocation, borrowing decisions, mortgage choices, and pension savings. RDRECON combines theory and evidence with an empirical research strategy that is comprised of both natural and field experiments. The theoretical component models how households make decisions. The empirical component uses both econometric and experimental methodologies to study actual household behavior across a range of economic and financial margins, as well as the influence of personal and market experiences on a household’s financial choices. RDRECON’s strength and path-breaking innovation is its combination of administrative register data and controlled field experiments to form treatment and control groups of interest which allow empirical identification of theoretical predictions. This approach puts theory to work and overcomes the limits of identification in natural experiments. To this end, RDRECON will further our understanding of how households respond to personal and market experiences, and provide helpful insights for policy makers.

Keywords: personal experience,field experiment,household finance
E3-hijacking molecular glues of RNA binding protein IGF2BP1 in ovarian cancer (E3glueRBP)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-03-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 159815.04
EU funding (EUR): 159815.04
Participants: 1
Project status: SIGNED

Conventional therapeutic strategy entails developing small molecules to occupy enzymatically active or regulatory pockets of the target protein, and further inhibit its biochemical activity. However, many disease-relevant proteins, such as RAS, MYC, or b-catenin, lack manageable druggable cavities. Bernardes and colleagues have raised a novel concept to overcome this limitation, named “molecular glues”, in which small molecules induce de-novo interactions between two proteins to modulate protein function. Molecular glues appeared as an elegant tool for targeted protein degradation, allowing simultaneous recruitment of a ubiquitin E3 ligase and the protein to be ubiquitinated. Notably, the potent anti-cancer drugs thalidomide, lenalidomide and pomalidomide (known as IMiDs for immuno-modulatory drugs), are the most prominent example of such E3-hijacking molecular glues, that exert their therapeutic effects through induced degradation of key efficacy targets. Building on these promising observations, herein I propose a designed platform that can rationally identify synthetic chemical matter to induce selective protein dimerization and induce disease-relevant protein ubiquitination and degradation – using ubiquitin E3 ligase and RNA binding protein IGF2BP1 as a proof-of-concept in ovarian carcinoma cells. The identification of complementary interfaces for drug-induced interactions will be achieved by computational prediction, protein-protein interaction assays, and a set of novel biochemical assays, together with high-throughput screening and structure-informed chemical optimization. This proposal will deliver a multi-layered technology to successfully design and validate novel molecular glues in a rational and generalizable way, to revolutionize current inhibitor-centric paradigms in cancer drug development and pharmacology. The strategy can be further transposed to other protein classes in different cancer types, and open an array of new therapeutic opportunities.

Keywords: molecular glues,e3 ligase,igf2bp1,cancer,drug development
Sea harvesting in the transition from hunter-gatherer to farmer societies. Archeological microscopic and molecular approaches to shell midden stratigraphy (SEArch)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-02-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

While marine resources played a crucial role in Mesolithic societies, the role of coastal adaptations associated with the first Neolithic farmers is still poorly known. The present project aims to investigate Mesolithic and Neolithic shell midden formation using sedimentary microscopic signatures on anthropic deposits from Atlantic Iberia. SEArch will apply state-of-the-art developments on lipid biomarkers and stable isotopes analysis of organic molecular data stored in archaeological sediments. The main objective is to understand behavioural and environmental changes associated with the exploitation of aquatic resources. SEArch will achieve this goal with a three-fold approach: (1) by reconstructing formation processes at key shell midden sites; (2) by identifying (macroscopically invisible) fish and shellfish to infer foraging locals and processing strategies, and (3) by inferring temporality of foraging behaviour using C and N stable isotopes. The project will create experimental datasets on thermal alteration of bioclasts and construct a novel marine biomarker database for archaeologists. The SEArch project seeks to contribute to the debate on the Neolithization process of western Europe by taking a contextualized approach to the study of coastal adaptations and their role as possible resilient behaviours during the Neolithization process.

Keywords: geoarchaeology,prehistoric coastal adaptations,archaeological micromorphology,archaeological biomarkers,stable isotopes,mesolithic,neolithic,shell middens
Global future health: a multi-sited ethnography of an adaptive intervention (FutureHealth)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-06-01
End date: 2023-11-30
Duration (months): 66.0
Total project cost (EUR): 1499977.0
EU funding (EUR): 1499977.0
Participants: 1
Project status: SIGNED

The proposed research project is a multi-sited ethnography of an emergent global health intervention to improve nutrition in the first 1000 days of life. The intervention links growth during this 1000-day window to chronic and mental illness, human capital, food security, and ecosystem sustainability, positing early life nutrition as the key to meeting the United Nations’ sustainable development goals. The intervention draws numerous disciplines and geographic regions together in a holistic pursuit of a sustainable and healthy collective future. It then unfolds in different settings in diverse and localized ways. The research team will work with first 1000 days experts as well as study deployment sites in Bhutan, the Netherlands, Guatemala, USA and the Philippines. The innovative anthropological techniques of contrasting and co-laboring will allow us to both analyze the intervention and contribute to its further fine-tuning. Health experts currently recognize that there are social complexities within and differences between the sites involved, but tend to treat these as obstacles to overcome. The innovative force of our research is to consider the adaptive transformations of the intervention as a source of inspiration rather than a hindrance. Where experts currently prioritize the question of how to translate expert knowledge into interventions in the field, we will ask how lessons from the field might be translated back into expert knowledge and, where relevant, made available elsewhere. In the process we will enrich the anthropological repertoire, moving it beyond a choice between criticism or endorsement, turning living with/in difference into both a social ideal and a research style.

Keywords: medical anthropology,anthropology of global health,multi sited ethnography,social transformation
Analysis, Design, And Manufacturing using Microstructures (ADAM^2)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Israel,Spain,Switzerland,Korea, Republic of,France,France,France
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 3399903.75
EU funding (EUR): 2999903.75
Participants: 12
Project status: SIGNED

ADAM^2 aims at questioning five decades of traditional paradigms in computer aided design CAD. While the field of CAD has been very successful in the last half a century using boundary representations, the introduction of microstructure into the design-analysis-manufacturing cycle is going to completely revolutionize geometric CAD from the ground up and into the essential volumetric representations, making an unprecedented leap in the quality of manufactured artefact. The evolution of new manufacturing technologies such as multi-material 3D printers gives rise to new type of objects that may consist of considerably less, yet heterogeneous, material, consequently being porous, lighter and cheaper, while having the very same functionality (e.g. stiffness) as the original object when manufactured from one single solid material. We propose a unified manufacturing pipeline that will focus on all stages involving Analysis, Design, And Manufacturing using Microstructures (ADAM^2). ADAM^2 proposes high-risky interdisciplinary research that will combine user-guided shape modelling using microstructures, followed by validation and structural optimization using physical process simulation, and finalized by physical realizations via additive and hybrid manufacturing and its subsequent validation. The results of this project will lead to scientific-technological development that impacts €2B/year CAD and €24B/year tool manufacturing European markets, and are expected to reduce the exploitation of heavy materials between an order of magnitude to two orders, in volume.

Keywords: additive manufacturing,material processing and optimization,validation of volumetric geometry
Fluorescence-based nano-immunoassay IVD platform (NIMM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 149952.0
EU funding (EUR): 149952.0
Participants: 1
Project status: CLOSED

Antibody-detection related to disease or to drug monitoring demands novel IVD tests that provide robust, rapid and early- stage diagnostics for improved and early on-set treatments. However, companies developing novel IVD immunoassays face an important barrier related to reimbursement policy issues when the IVD tests are introduced into national health systems. This barrier discourages many companies from pursuing the development of novel diagnostic tests because the investment necessary to introduce novel IVD tests in the market is hardly matched by the return of the investment. NIMM aims at providing a platform for the development of accurate, sensitive and inexpensive immunoassays for antibody-related conditions using a novel fluorescent nanosensor-based technology. The outcome of the project will pave the way to a commercial product to be sold in the Immunochemistry/Immunoassay segment of the IVD market, currently valued at 15 USD billion. Potential stakeholders in the outcome of NIMM include Public Health authorities and pharmaceutical companies.

Keywords: in vitro diagnostics,ivd test,antibody detection,antibody related disorders,fluorescence emitting systems,nanosensors