Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Multifunctional structures with quasi-solid-state Li-ion battery cells and sensors for the next generation climate neutral aircraft (MATISSE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Countries involved: Austria,France,Italy,Slovenia,Germany,Israel
Call: Greenhouse gas aviation emissions reduction technologies towards climate neutrality by 2050 (HORIZON-CL5-2021-D5-01, 2021)
Start date: 2022-09-01
End date: 2026-06-30
Duration (months): 46.0
Total project cost (EUR): 3469707.76
EU funding (EUR): 3469707.0
Participants: 8
Project status: SIGNED

MATISSE responds to the fourth bullet of the HORIZON-CL5-2021-D5-01-05 topic “expected outcome”, delivering improved aircraft technologies in the area of multifunctional structures capable of storing electrical energy for hybrid electric aircraft applications. This consists in integrating Li-ion cells into aeronautical composite structures, sharing the load-bearing function with the structure and achieving an aircraft structural element capable of functioning as a battery module. To do so, MATISSE will: • advance Li-ion battery cell technology, in a non-conventional formulation suitable for bearing structural loads: NMC811 (cathode), Si/C (anode) and bicontinuous polymer-ionic quasi-solid-state electrolyte (BCE), i.e. NMC811|BCE|Si/C, achieving 170-270 Wh/kg at cell level; • enable the functional integration of Li-ion cells into solid laminate and sandwich composite structures; • make the structural battery smart, by equipping it with on-cell and in-structure sensors, connected to a chip-based CMU (Cell Monitoring Unit) and PLC (Power Line Communication). MATISSE delivers a multifunctional structure demonstrator capable of power delivery, power management and safety monitoring. This consists of a full-scale wing tip (1.42 m × 0.69 m) for use in place of the current wingtip assembly installed on Pipistrel Velis Electro, embedding a module of 40 battery cells at 72 VDC. This will undergo a comprehensive testing and characterisation campaign, qualifying the technology at TRL 4 at the end of the project (2025). MATISSE will also encompass aspects related to flight certification, life-cycle sustainability and virtual scale-up, paving the way towards the application of structural batteries as an improved performance key enabling technology for next generation commuter and regional hybrid electric aircraft applications.

Keywords: multifunctional structures,structural batteries,hybrid electric aircraft propulsion,integrated sensors and cell monitoring,quasi solid state li ion battery,power line communication
Functional Coding of Neuropeptide Signaling Networks in Learning (NEUROPEPTALK)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2025-COG, 2025)
Start date: 2027-01-01
End date: 2031-12-31
Duration (months): 60.0
Total project cost (EUR): 2167296.0
EU funding (EUR): 2167296.0
Participants: 1
Project status: SIGNED

Humanity has always been intrigued by the brain’s ceaseless capacity to learn and store experiences. However, the ability to acquire and retrieve learned information is dynamic and regulated by a bewildering variety of chemical messengers. Neuropeptides form the largest and most diverse group of neuromodulators and play important roles in learning. Growing evidence exists showing that they form dense signaling networks, with most neurons expressing many neuropeptides and receptors, but how this complex network is engaged in learning circuits has not been systematically explored in living animals. Our working hypothesis is that the concerted actions and integration of neuropeptide signals mediates flexible control of learning circuits. We will test this hypothesis in the small and well-described nervous system of C. elegans, building on system-wide peptide network maps recently generated by my group. Given their high diversity, such a controlled context for penetrating the complex neuropeptide “language” in learning circuits is preferable. We will first identify the molecular pathways by which C. elegans neuropeptide GPCRs modulate neural activity, as this will provide the foundation to dissect their concerted actions. We will then systematically test how neuropeptide pathways impact short-term aversive learning in defined gustatory and olfactory circuits, study their impact on whole-circuit activity, and determine their temporal dynamics. Pertinent questions we will address include: ‘What are the unique versus redundant effects of neuropeptides in a learning context?’; ‘How do cellular networks encoding aversive experience respond to and integrate neuropeptidergic network activity?’ and ‘When do neuropeptidergic networks act to potentiate or attenuate learned responses?’ We expect on the long term, this project will impact our understanding of how neuropeptide networks influence and organize learning, forgetting, and adaptive behavioral responses in general.

Keywords: neuropeptide signaling networks learning caenorhabditis elegans g protein coupled receptors
SPACTORY, revolutionising pharmaceutical development and manufacturing through microgravity (SPACTORY)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 3120075.0
EU funding (EUR): 2184052.5
Participants: 1
Project status: SIGNED

Over 2,000 R&D experiments have been done in Space until now. Space near-zero gravity yields biochemical crystals orders of magnitude more defined, pure, uniform, and precise than in terrestial environments. The low-gravity accelerates the development and preclinical testing of complex molecules –e.g. proteins- and unleashes the potential of innovative high-value mAbs therapies, saving patient’s lives and improving their QoL. To make it real, after 11 space missions, SPACEPHARMA is committed to bringing the first mAbs factory to Space. MOTI, the main SPACTORY building block, brings accessible, scalable, and affordable microgravity manufacturing controlled from Earth and able to fly in any satellite compatible with any launcher. For our customers, the pharma industry, it means shorter time to Space, faster market access and affordable drug development. For SPACEPHARMA, it is a paradigm shift from drug R&D to manufacturing. For EU, it means leading the spatial race in drug development.

Keywords: drug manufacturing lab on chip uncrewed spacecraft micro factory in orbit antibodies protein crystallization remote controlled platform microgravity microfluidics oncology cancer
Plasmonic nanopore technologies for automatic manipulation and Raman spectroscopic sequencing of single proteins (RamanProSeq)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Finland,Germany,Italy,Portugal,United Kingdom
Call: EIC Pathfinder Open (HORIZON-EIC-2025-PATHFINDEROPEN, 2025)
Start date: 2026-05-01
End date: 2029-04-30
Duration (months): 36.0
Total project cost (EUR): 2999980.0
EU funding (EUR): 2999980.0
Participants: 6
Project status: SIGNED

The human proteome offers unprecedented insights into health, diseases and treatment. The current protein detection techniques are either expensive, insensitive, complex or introduce biases. Meanwhile, no amplification methods for proteins exist, which complicates their detection and leads to a serious lag of proteomics behind genomics and transcriptomics, hampering not only mechanistic studies but also clinical applications. The RamanProSeq project aims to develop a label-free optical single-molecule protein sequencing technology capable of reading protein primary sequence at single-amino-acid resolution with high accuracy (>99.9%). The proposed technology will revolutionise the field of proteomics towards personalized medicine and early diagnosis of diseases. The project will be based on the partners' approaches: ultrafast Raman spectroscopy with 1 microsecond time resolution and plasmonic nanopore-enhanced Raman sensors that have demonstrated single-molecule identification of 20 proteogenic amino acids, their post-translational modifications and discrimination of single amino acid residues within single peptides. Such achievement has addressed the long-standing challenge of current single-molecule technologies that cannot detect all 20 proteinogenic amino acids. Based on these approaches, the RamanProSeq project will integrate solid-state nanopores with a high-speed Raman detection system, an automated control system, computer simulations, and advanced Raman-based bioinformatics. The output of the project will be a novel nanopore-based device that will be used to sequence individual proteins at low concentrations and with high accuracy. The project will enable low cost, high resolution and high throughput in single-protein sequencing for a broad range of applications in life science and beyond.

Keywords: raman spectroscopy,plasmonic nanopores,single molecule protein sequencing,automatic control,molecular manipulation
Gaining leverage with spin liquids and superconductors (TROPIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 2324880.0
EU funding (EUR): 2324880.0
Participants: 1
Project status: SIGNED

TROPIC will design new experiments to uncover the topological properties of quantum materials that will revolutionize quantum computing. Conventional approaches that rely on local interactions between qubits suffer from seemingly insurmountable problems, such as controlling quantum decoherence while still achieving a useful number of qubits. Alternative approaches based on nonlocal topological excitations, such as Majorana fermions, could provide a solution but clear evidence for their existence is missing. TROPIC aims to identify topological signatures of quantum spin liquids and superconductors by revolutionizing a technique—resonant torsion magnetometry—that was recently developed by the PI. Our approach is unique in its extreme sensitivity to materials properties that are notoriously concealed. This proposal consists of three aims that focus on systems with promising hints of topology: the quantum spin liquid RuCl3 and the spin triplet superconductor UTe2. Each aim requires significant advances that will allow us to access the magnetotropic coefficient—the thermodynamic coefficient associated with magnetic anisotropy—in new classes of materials for the first time (aim 2) while obtaining new information (aim 3). The aims are summarized as: 1. Refining resonant torsion to identify topological order associated with Majorana fermions in RuCl3. 2. Extending resonant torsion to high magnetic fields to investigate unconventional superconductivity in UTe2. 3. Developing resonant torsion to higher frequencies to search for slow topological excitations. Recent media articles by quantum computing pioneers have warned that the hype is surpassing the performance. A material revolution is needed to realize the promise of quantum computing. We will develop a new experimental probes that will be applicable to broad classes of topological materials, including small and fragile 2D systems and heterostructures where thermodynamic measurements are needed.
Neuromodulatory control of brain network dynamics (BRAINAMICS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Italy,Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1999438.0
EU funding (EUR): 1999438.0
Participants: 2
Project status: SIGNED

Spontaneous brain activity, the most expensive metabolic process of the human brain, is highly dynamic and continually evolves over timescales of seconds. Human neuroimaging has made it possible to map dynamic patterns of spontaneous network activity with increasing precision. However, our understanding of the origin, function and organization of this phenomenon remains alarmingly limited. This project aims to elucidate the physiological mechanisms and operational principles that govern spontaneous network dynamics (termed here "brain network dynamics" - BND). To achieve these goals, I will establish an integrated research platform that combines advanced manipulations and recordings of BND in the awake mouse brain. To comprehensively probe the mechanisms that operate BND, I will carry out two complementary sets of causal manipulations that are conceptualized as exogenous or endogenous neuromodulation, depending on whether they encompass synthetic (optogenetically generated, Aim 1) or intrinsic (neurotransmitter related, Aim 2) modulatory mechanisms, respectively. Using this approach, I will (a) uncover the rhythms that causally sustain BND, and establish how BND causally responds to (and can be controlled by) mechanistically-precise exogenous neuromodulation; (b) empirically test the hypothesis that cholinergic and noradrenergic transmission cooperatively control the intrinsic organization of BND, as well the selective engagement of higher-order cortical systems relevant for attention and cognition. Crucially, multiscale network activity will be theoretically linked to dynamical regimes (brain states) of translational relevance via quantitative analyses. This research will address fundamental questions regarding the neural mechanisms governing BND and the possibility of controlling its organization via targeted exogenous modulation, with important implications for basic, theoretical and translational neuroscience.

Keywords: resting state fmri connectomics neuromodulation default mode network,large scale modelling brain stimulation,spontaneous brain activity meg
Petroculture’s Intersections with The Cultural Heritage sector in the context of green transitions (PITCH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Norway,Portugal,Netherlands,Finland,Germany,United Kingdom
Call: Cultural heritage in transformation – facing change with confidence (HORIZON-CL2-2023-HERITAGE-01, 2023)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 2737165.0
EU funding (EUR): 2737164.0
Participants: 11
Project status: SIGNED

Petroculture’s Intersections with The Cultural Heritage sector in the context of green transitions (PITCH) brings together academic and cultural sector organisation partners in six countries to spur on the processes by which humanities and arts scholarship and public interventions can strengthen citizen engagement with the constantly changing nature of cultural heritage and its relationship to past and present petrocultures. Our innovative and significant multi-site pilot events will provide a model for employing cultural heritage to creatively engage citizens to spur on environmentally-transformative shifts in both individual and collective organisational/institutional behaviours. We will provide heritage practitioners and policymakers with the tools to repurpose existing and future forms of heritage to facilitate just green transitions. PITCH will create a deeper understanding of petroculture’s intersections with heritage practices and how this reflects social, economic, and political changes over time through our historical and analytical work in archives and collections and map the secondary literature on the intersections between petrocultures and heritage cultures. We will conduct pilot interventions at three different types of sites (museums, industrial heritage sites, and heritage landscapes) with four cultural heritage partners to help citizens understand how petrocultures have affected their lives and be confident about how they might envision those lives otherwise. In order to ensure the long-lasting impact of the pilot interventions, we will collaborate with key international and European policy-making and practitioner organisations to help citizens face current and future societal transformations with greater confidence. We will develop policy briefings and digital toolkit to ensure the recommended methods are effective across the cultural, geographic, political and socio-economic diversity of Europe.

Keywords: cultural heritage,environment,climate change,fossil fuels,museums
Design of Electro-Thermocatalytic Reactors for Controlled Regeneration of Atom-Efficient Catalysts (ReGenCAT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

To address today’s environmental challenges, the production of energy and chemicals must rapidly change. The chemical industry currently relies on catalysts, materials that speed up reactions, in 90% of its processes. Catalysis will thus play a pivotal role in transitioning from our fossil fuel-based society to a more sustainable and renewable society. However, most catalyst materials rely on expensive and scarce metals. Even more strikingly, these metal-based catalysts can present very low atom efficiency (below 20%). In other words, most metal atoms are not used in the reaction. With 34 materials and metals identified as critical by the European Union, metal scarcity issues are thus key hurdles to achieving a clean energy transition. Finally, most catalysts lose their activity over time, and their regeneration is costly. Catalytic reactors and catalysts must be reimagined to face these challenges. The goal of ReGenCAT is to design a groundbreaking electro-thermocatalytic reactor capable of in situ regeneration of catalysts at low energy costs. The reactor will rely on atom-efficient catalysts called dilute metal alloys. By exploiting the dynamic restructuring of dilute metal alloys in response to changes in applied electrochemical potentials, the reactor will enable in situ regeneration of catalysts under mild conditions at low temperatures and pressure. It will yield synergy and increase the lifetime of catalysts in important reactions involving biomass-derived chemicals. In the long term, I envision that the unique integration of thermocatalysis and electrocatalysis developed in ReGenCAT will also significantly advance current and emerging sustainable technologies relying on renewable electricity - such as fuel cells and electrolyzers - by improving their overall efficiency.

Keywords: catalyst regeneration,dilute metal alloy catalysts,integrated electro thermocatalytic reactor
A Decentralized Operating System (DOS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-02-01
End date: 2027-12-31
Duration (months): 59.0
Total project cost (EUR): 1491838.0
EU funding (EUR): 1491838.0
Participants: 1
Project status: SIGNED

The DOS project targets the challenge of developing and deploying distributed applications on large-scale decentralized computing infrastructures (DCIs) such that their dependability properties, e.g., safety and security, can be enforced by the foundational layers of the system stack in a policy-compliant manner. While it is possible today to construct distributed applications, it is challenging to ensure that their dependability properties are preserved end-to-end in a DCI consisting of a diversified set of compute nodes hosted in multiple administrative jurisdictions. This situation is primarily caused by the limitations of existing system stack foundations: (a) hardware: DCIs expose heterogeneous compute nodes that lack a unified interface to access, isolate, and manage them; (b) OS: current OSes lack mechanisms for resource management in a safe and secure manner for heterogeneous nodes operating across multiple trust domains. As a result, programmers rely on ad-hoc programming and deployment mechanisms, which are not only prohibitively expensive to develop and error-prone but also cannot ensure compliance with the dependability requirements. The DOS project seeks to bridge this gap by pursuing a radically new hardware/OS co-design by introducing 1. a pluggable hardware component called Isolation Control Unit (ICU) that abstracts out the hardware heterogeneity while providing a minimalistic interface for resource management, isolation, communication, and trust establishment. 2. a microkernel-based Decentralized Operating System (DOS) that builds on ICUs to manage DCIs as a unified dependable system substrate to enable policy-compliant application deployment. Overall, our work aims to empower programmers by providing a generic distributed programming framework on top of DOS to concisely specify the dependability policies along with the application logic, while our system stack transparently enforces these policies in decentralized environments.

Keywords: operating systems,distributed systems,dependability,security,hardware software co design,programming model,policy compliance deployment,reliability