Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ultimate growth characterization for development of new semiconductor technologies (USEMITE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The integration of III-As structures with Silicon is of major importance to industry. Currently nanostructures are already being applied to information and communication technologies and their integration with Silicon electronics is being developed. Current fabrication techniques allow patterning of nanostructures from bulk layers but modify the properties of the materials by introducing defects. The ability to control nucleation and growth of self-assembled quantum nanostructures will propel the development of electronics and photonics. The combination of in-situ Low Energy Electron Microscopy (LEEM) during Molecular Beam Epitaxy (MBE) offers the possibility to directly observe the growth on real-time in real and reciprocal space. Therefore, to observe the nucleation dynamics, the lattice structure dynamics, surface dynamics, etc. The level of control that LEEM can provide to MBE is unheard of and unique. The goals of the MSCA project are: • Elevate current III-V LEEM system to enable direct interaction with MBE facilities, both research and industry based, across Europe. • Apply the technique to the fabrication of site-controlled nanostructures. • Transfer the growth conditions found during direct observations of the growth by MBE-LEEM to industrial fabrication of quantum devices. During the MSCA period, the LEEM-MBE will be used to study the nucleation of GaAs on Si, the nucleation of InAs QDs on GaAs, nucleation of InAs QDs on complex structures to induce site control nucleation using strain field, nucleation and growth of nanowires (NWs) using catalysts and self assembled. Additionally an aluminium anodization system will be fabricated and installed in order to deposit the catalyst in a hexagonal lattice along the area of the whole substrate. The latter project will be carried out by a PhD student which will be funded by Cardiff University.

Keywords: photonics,crystal growth,microscopy,molecular beam epitaxy,new electronics,semiconductor nanostructures
Building the product pipeline for commercial demonstration of Plant Molecular Factories (Pharma-Factory)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Innovation actions
Countries involved: Spain,Germany,Spain,Spain,Italy,Israel,Finland,France,France,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Plant Molecular Factory (H2020-BB-2017-1, 2017)
Start date: 2017-11-01
End date: 2022-08-31
Duration (months): 58.0
Total project cost (EUR): 9254335.0
EU funding (EUR): 8286008.63
Participants: 14
Project status: SIGNED

Plant Molecular Farming is the manufacture of high-value products using plant biotechnology. Pharma-Factory was conceived and designed by SMEs active in the field to produce medical, veterinary and diagnostic products. Product-driven work packages and a collective approach to public involvement and regulatory consultation will accelerate commercialisation of new bio-products, and increase the competitiveness of European bio-industry by resolving technical, social and economic bottlenecks in this field. All parts of the work programme are addressed by refining technologies using new synthetic biology tools, demonstrating manufacturing advantages for individual products, identifying a clear regulatory path for each platform technology, developing clear business cases with supporting techno-economic evaluations and life cycle analyses and improving public engagement and acceptance. Five SMEs will develop products that include arylsulfatase B (for human enzyme replacement therapy), a vaccine for infectious spleen and kidney necrosis virus in fish, two highly potent HIV neutralising antibody-based fusion proteins and plant chimaeric virus-like-particles for a diagnostic kit. In collaboration with academic partners they will advance six plant molecular farming platforms for this purpose, including whole plants, algae, hairy roots and plant cell culture, by designing and developing new tools to increase the competitiveness, utility and versatility of each platform. All companies will reach Technology Readiness Level 5 within the lifetime of the project, with two products to be commercialized. The project provides a unique opportunity to improve public involvement with plant biotechnology at a European-wide level. A work package has been dedicated to gain maximal impact by engaging with all stakeholders – from scientists to government and the public at large, developing new tools to facilitate communication, to help understand and reduce barriers to acceptance.

Keywords: molecular farming,plants,algae,pharmaceuticals,enzymes,diagnostics,recombinant proteins,regulation,rheumatoid arthritis,vaccines,public engagement
Fecal miRNAs, new mediators of host-microbiota interaction in Inflammatory Bowel Disease (miR-IBD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Growing evidences indicate that microRNAs (miRNAs) are present in various body fluids and contribute to cell-cell communication. My previous studies identified circulating miRNAs as efficient tool for the diagnosis and surveillance of Inflammatory Bowel Disease (IBD). Interestingly, miRNAs are secreted into the intestinal lumen where thousands of different bacterial species are present and confer important benefits to the host. This proximity prompted us to speculate that miRNAs and bacteria interact, playing a role in the host/microbiota relationship. My preliminary data generated to date demonstrate that fecal miRNAs are altered during intestinal inflammation in association with an alteration of microbiota composition, and we recently reported that exogenously administered miRNAs have the potential to alter microbiota composition and function. Here, our central hypothesis is that fecal miRNAs are mediators of host-microbiota interactions and therefore modulate intestinal inflammation. On the basis of this overarching hypothesis, I now propose to determine the role played by the intestinal microbiota in miRNA-mediated modulation of intestinal inflammation (objective 1: mechanism); Investigate the ability of specific miRNAs / anti-miRNAs to modulate intestinal inflammation. (objective 2: therapeutic) and to identify whether fecal miRNAs are indicators of microbiota and intestinal healthiness in IBD patients (objective 3: translational). We envision that the proposed experiments could identify a new role for miRNAs in manipulating the intestinal microbiota hence leading to the development of new therapeutic strategies.

Keywords: intestine,microbiota,mirna,inflammation,therapeutics
A high-dimensional approach for unwinding immune-metabolic causes of cardiovascular disease-depression multimorbidities (TO_AITION)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Switzerland,Greece,Poland,Finland,Greece,Greece,France,France,Netherlands,Netherlands,Netherlands
Call: Understanding causative mechanisms in co- and multimorbidities combining mental and non-mental disorders (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 5990515.0
EU funding (EUR): 5990515.0
Participants: 14
Project status: SIGNED

Depression is a common and serious comorbidity of cardiovascular disease (CVD) affecting one in three patients, among which women earlier and more frequently. Depression increases the risk for CVD development, acute events and mortality by >2 fold, independently of traditional risk factors, and constitutes an enormous socioeconomic burden in terms of morbidity, mortality and healthcare costs. Still, the patients at risk, disease trajectories and causative mechanisms involved remain unknown. TO_AITION addresses the hypothesis that immune-metabolic dysregulation, occurring as a result of genetic, lifestyle and environmental risk factors ‘training’ innate immunity, drives low grade systemic inflammation leading to the development of CVD-depression comorbidity. It integrates basic (cell models, immune-metabolic mechanisms, myeloid cell reprogramming), preclinical (animal models, CRISPR genome editing) and clinical (longitudinal cohorts with comprehensive existing data) research, in order to characterise immune-metabolic mechanisms driving CVD-depression comorbidity. Both hypothesis and data-driven strategies will be employed to address causality, focusing on genetic, epigenetic, transcriptional, metabolic and other disturbances leading to the development of comorbidity. Drug-drug interactions and their effects on causative mechanisms and disease trajectories will also be determined. Pathways identified will be evaluated in cell-based and animal models to prove their causal role and obtain mechanistic insight. Finally, new risk models will be developed, and relevant regulatory, cost-effectiveness and feasibility issues addressed. Effective patient-oriented awareness actions, dissemination, exploitation and management activities are also provisioned. TO_AITION will therefore rationally change our current understanding of the causative mechanisms driving CVD-depression comorbidity, unravelling patients’ complexity and improving their diagnosis, monitoring and management.

Keywords: cardiovascular,metabolic,depression,biomarkers,inflammation
A NOVEL SUSTAINABLE PAPER CUP FOR TAKE AWAY DRINKS (UCUP)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: United Kingdom
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Near 58 billion paper cups are used globally per year. This involves the consumption of one million tonnes of virgin paper, cutting down 32 million trees, the consumption of 100 billion litres of water, the generation of 25,000 tonnes of waste (solely in the UK), and the emission of greenhouses gases equivalent to half a million cars. Paper cups are often lined or coated with plastic such as polyethylene (PE) or oil- based waxes to prevent the liquid from leaking out or soaking through the paper. These paper cups are almost impossible to recycle because of the difficulties of separating the paper from waterproof oil-based liners. This means paper cups end up going to landfill or, at best, are incinerated to generate energy. The heavy environmental impact of paper cups is extremely unsustainable, with each one generating a carbon footprint of 0.11kg of CO2. UCUP, a novel sustainable paper cup for take-away drinks, provides an innovative solution to reduce the huge environmental impact of disposable cups. UCUP features an eco-innovative material obtained from brown seaweed which is bio-based, biodegradable and recyclable while it provides the same properties as current oil-based liners (waterproof, thermal and mechanical resistance) at a competitive price. Our main objective is to exploit the business opportunities of this new material in the food packaging and food services packaging (ready-to-eat & take away) sectors. We plan to launch UCUP onto the market and seek to further develop it to a market-ready product. We will use Phase 2 for this purpose, with a total investment of €2 million in 18 months. The overall plan is to market UCUP first in UK and speed up scalability at international level through a network of allies and partners. Thanks to this strategy, we expect to reach a turnover of €8.6 million and 22 employees by 2025.

Keywords: sustainable paper cups,seaweed,alginate,biodegradable,compostable and recyclable paper cups,eco friendly,food packaging
Vision-based Inspection Systems for automated Testing of Aircraft interiors (VISTA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy,Italy,Italy
Call: Development of systems for automated testing in the aircraft interior (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-02-01
End date: 2021-01-31
Duration (months): 36.0
Total project cost (EUR): 1196250.0
EU funding (EUR): 987375.0
Participants: 3
Project status: CLOSED

The VISTA project aims to post-assembly testing of aircraft interior installations in both cabin and cargo units in order to ensure quality and reliability of located components. This goal will be pursued by the development and implementation of a multi-sensor platform and sensor processing algorithms, integrating on-board a mobile system and an interface for data transmission, able to provide efficient automated testing and quality reports. In detail, multiple optical devices, including 3D LIDAR, omnidirectional laser profilometers, RGB-D, and (stereo) vision sensors, integrated with on-board image processing hardware, will be tested for the 3D modelling of the aircraft interior. In addition, the sensor suite will include line scan cameras for colour inspection of surface quality. All sensors will be integrated on an automated guided vehicle (AGV) that will collect and store sensor measurements, while traversing both cabin and cargo areas. The collection of full 3D models, i.e. 3D models augmented with metadata, such as colour, material and texture, will feed high-level algorithms that will automatically determine tolerances of the components with respect to positioning, gap and flush, and assess surface quality in terms of texture, colour, and defects. An interface for data transmission will be developed and tested for visualization and documentation, which will be made available to the human operators via suitable interfaces based on Augmented Reality (AR).

Keywords: quality control,color and texture analysis,image processing,computer vision,3d reconstruction,augmented reality,mobile robot localization
A fire-resistant, thermal and acoustic insulating lightweight fabric (smartMELAMINE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Germany,Slovenia
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 2338954.0
EU funding (EUR): 1637267.8
Participants: 3
Project status: CLOSED

The global market for technical textiles grows rapidly. It is accompanied by increasing customer needs and stricter regulations combined with the demand for lower prices. This is especially true for high-value markets such as automotive insulation, thermal protective clothing or hot gas filtration. Even though these segments appear to be quite different, the major needs are very similar: higher safety (thermal insulation, flame resistance), higher comfort (lightweight, acoustic insulation, filtration efficiency), better processability, lower price. As current solutions cannot fulfil these high demands and regulations, this represents an excellent opportunity for smartMELAMINE. By enabling thermoplastic processing of melamine in a dedicated meltblown process, it is possible to create a fabric with unmatched fibre fineness and a unique set of properties at costs well below competitive solutions. The project is based on a thorough business plan. In talks with more than 100 potential customers, the need for new solutions has been emphasized and a high interest in smartMELAMINE was confirmed. Samples at pilot-scale (width: 300mm) have been produced on a continuously updated pilot plant and tests in an industrial environment have confirmed the processability of the melamine-meltblown at larger scale (TRL6-7). The main objective of the phase 2 project is the upscaling of the production process to industrial scale (2,400mm) and the further improvement of fibre fineness and volume weight, in order to perfectly address the market needs. The partners combine unique know-how regarding melamine processing and meltblown technology. The joint venture SML will build on this know-how to facilitate the commercialisation of smartMELAMINE. Unlimited licenses and patents guarantee the freedom to operate. The project will contribute to strengthen the European leadership in the market for advanced technical textiles and create further employment and wealth throughout Europe.

Keywords: advanced materials,organic,nonwoven,meltblown,resin,fibre diameter,fineness,technical,textiles,melamine,etherified,protective clothing,filtration,automotive,fabric,lightweight
Sound Particles - The Revolution in 3D Audio Software (SoundParticles)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Portugal
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-09-01
End date: 2021-10-31
Duration (months): 26.0
Total project cost (EUR): 1780141.25
EU funding (EUR): 1246098.88
Participants: 1
Project status: CLOSED

The entire entertainment industry is adopting 3D sound in their products as a better way to immerse their audiences and offer an overall superior experience. Unfortunately, all existing audio software tools continue to use a 2D approach, which is very limited for 3D audio work, because of obsolete and costly workflows which are unable to adapt to the industry’s growing need towards 3D audio. SoundParticles is a disruptive 3D audio software that uses computer graphics techniques applied to audio. Combining particle systems techniques, a 3D CGI-like engine, SoundParticles is able to generate thousands of sounds in just minutes to create complex soundscapes, enriching the audio results and achieving an unprecedented realism in the audio software sector, while increasing the productivity of audio professionals. In other words: we create sounds like never imagined before. By doing this we are able to create a new audio standard and start a revolution in audio software for Cinema/TV, Videogames, VR/AR and Music. In the future we aim to bring value to millions of audio software users, from garage bands to Hollywood sound designers, from professionals to amateurs, as we firmly believe that Native 3D audio software will revolutionize entertainment audio, the same way that computer graphics revolutionized entertainment image. For our company, We estimate, that 5 years after completion, the project will bring accumulated net profit of €100,67M, resulting in a highly profitable ROI=42 and allowing short payback time of just 2 years. We will expand our workforce from current 10 people to 107, mainly in software development and sales. In fact, our MVP has already caught the attention of all major Hollywood studios, and has been used in more than 40 blockbuster movies, including StarWars – The Last Jedi, Pixar’s Cars 3, Despicable Me 3, Batman vs Superman, Spider- Man: Homecoming, and Steven Spielberg’s Ready Player One.

Keywords: sound,audio,cinema,videogames,entertainment,post production,software,movies
The dynamics and rheology of self-assembled empty liquids: from patchy toy models to anisotropic realistic systems (DELTAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

In this project I plan to investigate by means of numerical simulations the dynamics and rheology of low-density equilibrium gels made of limited-valence building blocks. I will start with simple toy models of patchy particles and then add complexity in the form of inner degrees of freedom by investigating systems that undergo a hierarchical self-assembly process. Examples of such systems are recently synthesised DNA constructs and telechelic star polymers. The novelty of DELTAS lies in the focus put on the role of the internal flexibility as a tool to tune the dynamics and the rheology of equilibrium gels. Indeed, the possibility of fine-tuning the structure of these materials lend themselves well to many applications, ranging from medicine to material science. The project goes one step further by proposing to investigate the kinetics, dynamics and mechanical properties of these systems in the framework of (flexible) patchy systems. The usage of simple toy models will grant a better understanding of the phenomenology of these systems. In addition, the realistic systems I plan to investigate will, on one hand, establish a stronger link between theory and numerical simulations and experiments and, on the other hand, provide a testing ground for the results obtained with toy models.

Keywords: dynamics,rheology,gels,physical gels,hydrodynamics,patchy particles,colloids,patchy colloids,polymers