Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A MILLION QUBIT QUANTUM COMPUTER - HIGHLY SCALABLE SOLID STATE QUANTUM COMPUTING PLATFORM WITH NATIVE OPTICAL NETWORKING (QUANTITATIVE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Israel
Call: Emerging quantum technology components (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-12-01
End date: 2026-11-30
Duration (months): 24.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

HIGHLY SCALABLE SOLID STATE QUANTUM COMPUTING PLATFORM WITH NATIVE OPTICAL NETWORKING – A MILLION QUBITS QUANTUM COMPUTER Quantum Transistors is a quantum chip and computer company, which aims to be the next "Nvidia" of the quantum computing world. We design and aim to manufacture (semi-fabless) an integrated quantum processor unit. Our initial device will use cooling to only 77k, thus avoiding the need for a huge-size and high-energy sub-Kelvin refrigeration system. Our solution will enable a server form factor and substantial savings in energy and space. In the long term, we aim to get our technology to room temperature and allow for a far wider adoption even to consumer devices. Our highly scalable solution can scale from x10s of thousands of qubits to millions of qubits and beyond. We rely on mass-scale fabrication and enable a fraction of the cost, small size, and high operating temperature.

Keywords: quantum computing scalable components
Understanding malignant transformation of precancerous lesions in human colon (Transformation)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 1998750.0
EU funding (EUR): 1998750.0
Participants: 2
Project status: SIGNED

A crucial milestone in tumor progression is the transformation from a benign adenoma to a malignant cancer, which has profound impact on clinical outcome and therapy design. Despite its importance, it is poorly understood why it manifests itself as a bottleneck that can restrain precancerous adenomas for years. While recent sequencing efforts inform ‘static’ insights into the status of cancer genomes, these are incomplete to infer how they evolved, assess functional consequence of mutations, nor how much malignancy is environmentally instructed. Practical limitations hamper scientific advancement into the dynamic nature of tumor evolution. Foremost, studying human tumor evolution is challenging as sequential sampling is not feasible, and pre-malignant events that may hold the clue for understanding transformation often occur years before cancer diagnosis. Moreover, experimental models that reflect malignant transformation, let alone of human origin, are lacking. TRANSFORMATION aims to resolve how human cancer genomes evolve towards malignancy, and its role in triggering malignancy. To gain new insights on this matter, TRANSFORMATION takes a unique approach to produce experimental insights into evolutionary parameters that are inherently dynamic in nature and cannot be obtained from tumor sequencing alone. Using paired biopsies from early-stage colon cancers, I generated unique organoid models from pre- and post-transformation regions. Together with in situ analysis of matched tumors, TRANSFORMATION will reveal the elusive rate and order by which mutations and copy-number alterations are acquired, the patterns by which cancer karyotypes evolve, dissecting functional from non-functional genetic heterogeneity on tumor phenotypes and investigate possible selection pressures imposed by environmental conditions. TRANSFORMATION will solve how colon tumors evolve pre-malignancy, which properties promote malignancy and why transformation is an evolutionary bottleneck.

Keywords: colon cancer,adult stem cells,organoids,chromosomal instability,tumor evolution,malignant transformation,pre malignancy
Film-Philosophy as a Meditation on Death (FILM AND DEATH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Portugal
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1703834.0
EU funding (EUR): 1703834.0
Participants: 1
Project status: SIGNED

FILM AND DEATH defends the hypothesis that to film-philosophize is to learn to die. This will be achieved by rethinking the innovations that film brings to recent philosophies of death and the metaphysics of time. A new paradigm for understanding the relationship between film and philosophy is proposed that claims 1) that film-philosophy’s methodology is a meditation on death, and 2) that ‘films think’ and have their own ways of creating novel thoughts that are not our own. One of these thoughts concerns death, a phenomenon of which we have no image but that film renders visible as a death-image (a direct image of passing time, facing the impossibility of any representation). We will assert that the cinematic experience is in itself equal to awareness of one’s own mortality, as a memento mori, without which we would not philosophize at all. The project has three key aims: 1) to demonstrate that film-philosophy contains significant philosophical insights; 2) to show that such insights are best understood by means of film’s novel ways of thinking of time, finitude, and death; and 3) to argue that film’s thinking about finite time gives new meaning to philosophy’s traditional role as a meditation on death. To support this, a new conceptual map for studying the ways in which death and time are linked through moving images is proposed. The project will offer a contemporary view on death as a cultural phenomenon that has shaped twentieth-century thinking in general and films in particular, putting the usual anthropocentric definitions of death into perspective. A timely undertaking given the ever-growing presence of film and moving media in our lives, it will probe and question our own paradoxical existential condition as members of a thanatophobic society that rarely focuses on death in the everyday but discusses it readily when it is depicted in movies and TV.

Keywords: philosophy of film
SELF assessment, protection & healing tools for a trustworthY and resilient CCAM (SELFY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Partnership: CCAM (co-programmed)
Countries involved: Spain,France,Germany,Netherlands,Türkiye,Austria,Australia,Japan
Call: Cyber secure and resilient CCAM (CCAM Partnership) (HORIZON-CL5-2021-D6-01, 2021)
Start date: 2022-06-01
End date: 2025-05-31
Duration (months): 36.0
Total project cost (EUR): 5998899.5
EU funding (EUR): 5998899.0
Participants: 18
Project status: SIGNED

SELFY will increase CCAM ecosystem’s safety, security, robustness, and resilience by researching and developing a toolbox made of collaborative tools which main pillars are: (i) situational awareness, through collaborative perception and monitoring; (ii) data sharing, advanced processing for detection of malicious events and decision-making; (iii) resilience, increased ability to adapt and respond to cyber-threats and cyber-attacks; and (iv) trust, including guarantees regarding privacy, confidentiality, integrity and immutability of data in a collaborative CCAM environment. SELFY tools can operate individually and/or cooperatively with other tools, generating a distributed global solution, where SELF-protection, SELF-response and SELF-recovery decisions will be managed locally or globally as appropriate for any given cyber-attack, malicious activity or hazard, extending the Operational Design Domain (ODD) In Europe, 50 million connected cars are expected in circulation by 2026, and EU regulations requires for cybersecurity certificates for vehicles. In this scenario, SELFY long term impact is grounded on a value proposition that is OEM and/or vendor agnostic, thus facilitating adoption at all stages of the value chain. Additionally, the consortium involves all necessary stakeholders for co-creating a sound and comprehensive CCAM solution: including OEMs, road operators, traffic and infrastructure management, researchers, and policy-makers. SELFY expected outcomes include 5 traffic and infrastructure management organizations adopting the SELFY toolbox, which will benefit of a >90% effectiveness rate in detection of vulnerable vehicles and security breaches and an increase of >75% off the mitigation rate at demonstrated in TRL6 by the end of the project.

Keywords: secure and resilient ccam by design,tdms trust data management system,sacp situational awareness cooperative perception,crhs cooperative resilience and healing system,agnostic,self x,odd
Empowering and Connecting Diverse Communities for Multi-Hazard Resilience with Open Data, Open Models, and Open-Source Software (ECHO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Resilient Infrastructure
Action type: Innovation actions
Countries involved: Luxembourg,Greece,Italy,France,Slovenia,United Kingdom,Spain,Belgium,Ireland,Switzerland
Call: Resilient and secure urban planning and new tools for EU territorial entities (HORIZON-CL3-2024-INFRA-01, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 7472315.31
EU funding (EUR): 5999865.72
Participants: 30
Project status: SIGNED

As (peri-)urban areas become increasingly digital, interconnected, and complex, alongside growing threats such as climate change, natural disasters, or cyber-attacks, there is an urgent need to enhance the resilience and security of critical infrastructures (CIs) and the essential services they support. ECHO addresses these challenges by creating a multi-level Resilience Ecosystem that unites CI operators, Emergency Service Providers (ESPs), local/regional authorities (AUTs), and emergency service providers (EMPs) to co-create innovative tools, services, and strategies, for enhanced (urban) resilience planning and management. ECHO develops an EU-sovereign Knowledge Hub and a suite of interoperable, modular, and cost-effective services, accessible via a centralized Platform. These include tools for threat forecasting, risk assessment, situational awareness, decision support, resilience plan evaluation, and scenario-based simulations, tailored to address diverse multi-hazard threats. Our Information Sharing Protocol ensures cost-effective resource pooling and collaboration, helping smaller municipalities overcome budget constraints. By using cutting-edge technologies such as Generative AI, we enable advanced modelling, forecasting, and decision-making while ensuring transparency and data security. ECHO operates through 4 pilot sites in Slovenia, Italy, Spain, and the cross-border Italy-Slovenia region, addressing multiple hazards (floods, landslides, drought, earthquakes, wildfires, infrastructure failures, cyber-attacks) and engage diverse stakeholders (AUTs, ESPs, EMPs) to test and validate our solutions in relevant settings, ensuring scalability and adaptability across Europe. Through comprehensive impact-generation activities, ECHO promotes best practices, empowering stakeholders of all sizes to strengthen the resilience of interconnected systems, enhancing the security and wellbeing of European citizens and communities.

Keywords: resilience,cooperation,training,artificial intelligence
Ice-sheet thickness reconstruction with uncertainty quantification (IceSTRUQ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-08-01
End date: 2028-07-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

The Antarctic and Greenland ice sheets are fundamental to the Earth's climate system and the main contributors to sea-level rise. The overall ice-thickness distribution of an ice sheet is computed from sparse ice-thickness measurements using reconstruction methods. This data sparsity results in a marked uncertainty of the ice-thickness reconstructions, which is never taken into account in a mathematically rigorous manner. This implies large deviations between different ice-thickness reconstructions, delivering inconsistent estimates of sea-level rise rates. To remedy this, we propose formulating the ice-thickness reconstruction as a Bayesian inverse problem that combines data and mathematical models for ice-sheet dynamics. The solution of this inverse problem is a probability distribution for the ice-thickness, resulting in a rigorous quantification of uncertainty. However, conventional numerical methods either break down or become impractically slow when solving this problem. To circumvent this, we propose the design of a Monte-Carlo Markov-Chain (MCMC) method that combines ideas from multi-fidelity and the stochastic Newton MCMC methods. These are two sophisticated mathematical techniques that have achieved extraordinary reductions in computational time, allowing for previously unfeasible computations. We will apply our method to reconstruct the ice-thickness of the Antarctic Peninsula Ice sheet (APIS). This important Antarctic region has a complex geometry that has defied existing ice-thickness reconstruction methods. Our Bayesian inversion approach has the potential of reconciling dissimilar estimates of ice-discharge by quantifying confidence intervals via uncertainty. This highly interdisciplinary project will develop the applicant's mathematical and glaciological knowledge in an internationally-recognized research team. Research will be complemented with enriching activities such as Antarctic fieldwork (as training) and supervision of PhD students.

Keywords: bayesian inverse problems,mcmc methods,ice discharge,sea level rise
Exploring the potential of oleaginous microalgae Monoraphidium neglectum for wax ester production (MONOWAX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

Wax esters (WEs) are neutral lipids of major industrial importance, used as components of lubricants, pharmaceuticals and cosmetics. Large-scale production of WEs is based on chemical processes, which utilize mainly petroleum-derived feedstocks and generate hazardous waste. With diminishing fossil reserves, demand on industrial raw materials and predicted effects of global warming, there is a strong need for alternative bio-based production of WEs from renewable resources. Since WE synthesis requires only two enzymes: fatty acyl reductase (FAR) and wax synthase (WS), metabolic engineering approaches enabled WE production in genetically modified plants, bacteria and yeast. Interestingly, to date there are no reports on establishing WE synthesis in oleaginous microalgae, which due to fast growth rate and high oil content are strong candidates for the WE-producing platforms. Among them, a green alga Monoraphidium neglectum is a particularly promising species due to its favourable fatty acid profile. The main goal of the project is to establish WE production in M. neglectum using genetic engineering and its further enhancement via optimisation of culture conditions or/and further modification of lipid metabolism. In the first stage of the project, I will develop a vector toolkit for efficient gene expression in M. neglectum. Then, I will use the toolkit to introduce different combinations of FARs and WSs to microalgae cells. I will also investigate whether WE accumulation in M. neglectum can be modulated by stress conditions. Finally, the cultures of WE-producing transgenic microalgae be scaled up to verify their productivity and WE yield. In parallel, I will test several strategies to boost WE production by modification of carbon flux in a model green alga Chlamydomonas reinhardtii and use the most successful ones to further modify M. neglectum. The outcome of this project will be a valuable contribution to the future development of new strategies to produce WEs.

Keywords: microalgae,metabolic engineering,wax esters,fatty alcohols
A Direct Sensorimotor Connection with the Spared Neural Code of Movement to Regain Motor Function (GRASPAGAIN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1495271.0
EU funding (EUR): 1495271.0
Participants: 1
Project status: SIGNED

Many individuals suffer partial or complete muscle paralysis with no available cures. Even though neural interfaces have the potential to restore motor function with assistive systems, their use is still very limited. Even in the case of state-of-the-art invasive neural implants, the control of the movements of the paralyzed limbs is highly unsatisfactory. These neural interfaces suffer high surgical risks, poor control of the activity of spinal motor neurons, and inaccurate mapping of the attempted movements. Spinal motor neurons are the last cells of the nervous system that convert motor commands into movement and their activity can be accessed with minimally invasive methods. In most neural lesions, such as spinal cord injury and stroke, there are functionally active spinal motor neurons projecting to paralyzed muscles that are modulated by brain input. In this project, I propose a bidirectional interface that is driven by the real-time identification of efferent spinal motor neuron activity. We will develop novel sensing, decoding, and feedback methods with precise cellular resolution. This neural interface will map, engage, and augment the spared output of the spinal cord through new deep learning methods and hundreds of fine-tuned electromyographic sensors recording action potentials of individual motor units for the muscles controlling the hand. The output of this interface will enable highly accurate temporal associations between efferent motor neuron activity and sensorimotor feedback by delivering multiple visual and somatosensory inputs. This bidirectional neural interface will entrain and monitor the spared neural pathways at the direct cellular level with the goal of transforming and augmenting the activity of the spared motor neurons into highly functional motor dimensions. Using these new technologies, we aim to answer open questions in movement neuroscience and spinal cord injury.
Lymphoid Organoids to Study Immune Synapse in Lymphoma Therapies (LOISE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2025-06-30
Duration (months): 36.0
Total project cost (EUR): 265647.84
EU funding (EUR): 265647.84
Participants: 2
Project status: CLOSED

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL) in Europe and worldwide with more than 463/100 000/year. Activated B cell (ABC)-DLBCL represents the more aggressive and chemo-resistant subtype to the frontline therapy Rituximab (R)-CHOP (doxorubicin, vincristine, prednisone, mechlorethamine) with 40% of patients experiencing no response or relapse. Therefore, new treatments are needed to improve the clinical outcome of ABC-DLBCLs. A newly defined characteristic feature of the ABC-DLBCL subtype is the concurrent constitutive activation of B cell receptor (BCR) and Toll-like receptor (TLR) pathways that result in the upregulation of the NF-ĸB through cooperative signaling. In ABC-DLBCLs the NF-ĸB signal is mediated from the downstream regulator Mucosa-associated lymphoid tissue lymphoma translocation protein 1(MALT1) paracaspase that is upregulated in 70% of these tumors.. For this reason, MALT1 paracaspase has become an attractive therapeutic target and MALT1 inhibitors have been developed.. However, previous studies indicate that approximately 63% of patients respond to BCR pathway inhibitors, and therefore understanding factors such as the intricate survival signals imparted by the lymph node tumor microenvironment (LymphTME) in ABC-DLBCL is critical for clinical translation of MALT1 inhibitors. Two key elements of the LymphTME are the infiltration of T helper cell (Th) and the activation of ECM mediated pathways. The Aim of LOISE project is to establish an ex vivo organoids that will mimic the T immunological synapse and ECM features with the purpose to elucidate their role on ABC-DLBCL survival and signaling response to BCR pathway inhibitors. These organoids will be used to designed a combinatorial targeted therapy for ABC-DLBCL.

Keywords: lymphoid organoids,diffuse large b cell lymphoma,biomaterials,hydrogel,ecm,malt inhibitors,live imaging