Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Long Duration Distributed Energy Storage System for Guaranteed Renewable Energy Supply (Solenco PowerBox)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Belgium
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 0.1
EU funding (EUR): 0.1
Participants: 1
Project status: SIGNED

Solenco Power NV has developed Solenco Power Box (SPB™), a Long Duration Distributed Energy Storage System to prompt the deployment of renewable energy (i.e., wind and solar photovoltaic) in multi-residential and commercial applications. SPB™ is based on the concept of reversible fuel cell, and its design relies on a patented solution invented by the CEO and Founder, Dr. Hugo Vandenborre, having a long-standing expertise in the field of hydrogen and hydrogen-based energy storage systems. Our pioneering solution can store energy in electrolysis mode and generate both electricity and heat (in the form of water at 80°C) in fuel cell mode, guaranteeing an overall efficiency of 92%, projected to reach 95% with further engineering and manufacturing optimisation. The commercial unit of SPB™ has a nominal power and heat capacity of 60 kWe, while hydrogen is safely stored in steel vessels up to 300bar, minimizing land occupation and providing adaptability to different contexts. SPB™ is the missing link for the mass uptake of renewable energy at a distributed level, figuring itself as a driver for the full development of an affordable, secure, and reliable energy system.

Keywords: energy storage,renewable energy,hydrogen energy storage,reversible fuel cell,long duration energy storage
Transportable Hyperpolarization for Imaging (TRYP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-02-01
End date: 2025-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Over the last five decades, Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) have become indispensable in analytical chemistry and medical diagnostics. Progress in high magnetic fields has elevated resolution and sensitivity, enabling faster data collection at minimal concentrations. However, the sensitivity of magnetic resonance has bounds. Hyperpolarization techniques, particularly Dissolution Dynamic Nuclear Polarization, are gaining attention for enhancing sensitivity. The downside is that hyperpolarization equipment is costly, operationally expensive, and technically challenging, hindering its widespread adoption in MRI facilities. A promising solution involves using transient photoexcited agents like triplets or photogenerated radicals. Our recent innovation leverages phase separation to extend hyperpolarization lifetimes of certain 13C-labelled targets to several hours. This facilitates the storage and transport of hyperpolarized molecules at 4.2 K. The upcoming TRYP validation will adapt this phase-separation approach to various samples, such as molecules and biological fluids, without using contaminating solvents. This method could democratize hyperpolarization benefits for the broader NMR and MRI communities. Specialized centers could produce and distribute hyperpolarized "consumables" that can be easily introduced into NMR or MRI systems. These matrices can polarize almost any water-based molecular solution for extended periods, enabling their long-distance transport to MRI centers, and can be easily filtered using conventional technologies.
Decoding the regulatory control of floral induction in apple (Malus domestica) (FlowCODE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-03-04
End date: 2026-03-03
Duration (months): 24.0
Total project cost (EUR): 181803.99
EU funding (EUR): 181803.99
Participants: 2
Project status: SIGNED

Floral induction (FI), the decision enabling a meristem to become floral, is important to reproductive success and yield production, yet its transcriptional regulation is virtually unknown in apple and other fruit tree species. The central FI mechanism appears conserved in all species in which it has been studied, although it is the regulation that enables environmental adaptation. FI is activated via multiple environmental and internal cues, mediated through various flowering pathways and converging at the highly homologous genes, FLOWERING LOCUS T (FT) and TERMINAL FLOWER 1 (TFL1), which act as an FI promoter and inhibitor, respectively. In Arabidopsis, flowering pathways have been extensively studied; however, the perennial lifecycle, dormancy requirements and flowering behaviour of apple, in addition to the ancestral duplication of the genome, mean FI control is likely very different in this species. The transcription factors (TF) and cis binding motifs identified in Arabidopsis provide a starting point from which to unravel apple FI regulation and it appears the GA pathway may also play an important role. FlowCODE will decipher the molecular control of FI in apple by identifying TFs that control transcription of FT- and TFL1-like genes and how they affect this expression. Equally, regulatory elements within the apple FT and TFL1 genes will also be ascertained. The significant genetic variation in FI-related traits, such as the proportion of floral buds per tree, across apple varieties will be used as a tool to link molecular regulation with its phenotypic effects. Additionally, studying this regulation in the context of the GA pathway will provide insight into its role in influencing this variation in FI behaviour. In deciphering FI regulation, possible approaches to protect fruit production from climate challenges will be revealed and enable development of more resilient varieties of apple and other fruit tree species through new breeding technologies.

Keywords: floral induction,flowering,apple,flowering locus t,terminal flower 1,transcription factors,cis and trans regulatory elements,gibberellin
EARLY DYNAMIC SCREENING FOR COLORECTAL CANCER VIA NOVEL PROTEIN BIOMARKERS REFLECTING BIOLOGICAL INITIATION MECHANISMS (DIOPTRA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Research and Innovation actions
Countries involved: Greece,Netherlands,Cyprus,Belgium,Lithuania,Slovenia,Denmark,Spain,Austria,Switzerland,United Kingdom,Latvia,Italy,Luxembourg,Croatia
Call: Develop new methods and technologies for cancer screening and early detection (HORIZON-MISS-2021-CANCER-02, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 13647600.8
EU funding (EUR): 13646550.5
Participants: 31
Project status: SIGNED

DIOPTRA aims to introduce a front-line screening tool that will consider risk factors and protein biomarkers for pinpointing individuals at a high risk for colorectal cancer (CRC) incidence. Tissue & blood samples will be examined towards a discriminative set of prognostic proteins that are detectable via standard bloodwork and can indicate a need for further evaluation (i.e. colonoscopy). Other data (e.g. medical, behavioural) will also be considered as potential risk factors. Artificial intelligence (AI) will be leveraged for assessing prognostic power, while personalised behavioural change will be promoted based on modifiable risk factors. Given the low citizen participation on CRC screening across EU, DIOPTRA seeks to broaden the evaluated population, boosting participation rates and bypassing age screening thresholds. This action is part of the Cancer Mission cluster of projects on ‘Prevention, including Screening’.

Keywords: colorectal cancer
Quantitative Stability and Regularity of Large Data for Conservation Laws (we-will-shock)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

The proposed project will focus on the well-posedness theory for hyperbolic systems of conservation laws in multiple space dimensions. The project will consider the stability and well-posedness theory for such systems, in the cases with and without source. In his 2023 survey of the field, Dafermos writes that "in regard to systems [of conservation laws], in one spatial dimension, the fundamental question whether the Cauchy problem in the BV setting is well-posed for initial data with large total variation remains wide open.'' Our program to study quantitative stability will allow us to consider not only large BV solutions, but also large L^2 solutions with "infinite BV." Classically, the best theory of well-posedness for hyperbolic systems in one space dimension is the L^1 theory of Bressan and coworkers, which considers small-BV solutions. Recent results of the researcher, Chen, and Vasseur go significantly beyond the classical small-BV theory, and are able to treat even large L^2 data. The theory uses the technique of a-contraction, and the key assumption is a strong trace condition, a regularity assumption strictly weaker than BV_loc. Our first main objective in this proposal is to quantify the stability in the a-contraction theory, which hasn't been done so far. More precisely, Objective 1 (Quantitative stability): In the setting of large data, derive quantitative stability estimates between L^2 and BV solutions for a large class of systems in one space dimension. The strong trace condition is the key boundary between general weak solutions and the solutions we can show uniqueness for. This brings us our Objective 2 (Regularity): For scalar conservation laws, possibly with nonlocal or unbounded source, under mild technical assumptions, show the existence of the strong traces. This is open even in the one dimensional scalar case with unbounded source. Showing the existence of strong traces would be a significant step towards the program of Dafermos.

Keywords: compressible euler system,conservation laws,shocks,discontinuous solutions,uniqueness,stability,weighted contraction with shifts
Optimizing Antiambipolarity in OMIECs for Efficient Biohybrid Synapses (OASYS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-15
End date: 2027-08-14
Duration (months): 24.0
Total project cost (EUR): 236340.0
EU funding (EUR): 236340.0
Participants: 2
Project status: SIGNED

Neurological diseases are now the leading contributor to the global health burden, affecting one in three individuals worldwide. In response to this critical issue, the development of innovative organic mixed ionic-electronic conductors (OMIECs) that emulate the ion-regulated electronic conductivity and dynamics of biological ion channels when implemented in organic electrochemical transistors (OECTs) has paved the way for electronic devices capable of replicating neuronal functionality, namely conductance-based organic electrochemical neurons (c-OECNs). Despite the progress towards emulating biological neuron functions, current c-OECNs are limited by their inability to generate biologically plausible spike frequencies and their high power consumption, which hinder their integration with biological systems. In this sense, OASYS plans to overcome this challenge by developing innovative OMIECs with optimized ambipolarity characteristics and fabricating wearable and biorealistic c-OECNs that can be fully integrated with biological systems. This will be realized by using rationally designed bithiophene imide (BTI)-based polymers that operate at low gate voltages, enabling faster OECT devices with reduced power consumption and enhanced spike frequencies. OASYS integrates cutting-edge polymer design, advanced material characterization, and innovative device engineering in an application-oriented approach to tackle critical challenges such as antiambipolar tunability, selective sensing, wearability, and biointegration.

Keywords: organic mixed ionic electronic conductors,organic electrochemical transistors,antiambipolarity,neuromorphic perception,conductance based organic electrochemical neurons,biohybrid synapses
MIcrobe-synthesised DNA NAnostructures for DIsplay-controlled Storage Cartridges (MI-DNA DISC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Austria,Germany,Croatia,Italy
Call: EIC Pathfinder Challenge: DNA-based digital data storage (HORIZON-EIC-2022-PATHFINDERCHALLENGES-01, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 3999506.5
EU funding (EUR): 3999506.5
Participants: 6
Project status: SIGNED

DNA has a huge potential for the long-term storage of large amounts of data. However, writing, editing, and reading DNA-based data is expensive and inefficient with current technologies. Our vision is to develop a low-cost, energy-efficient, and fast data drive that is able to write, edit, store, and retrieve DNA-based data. The data drive is based on simple and easily available hardware components plus bacterial cells. The proposed technological solution enables the short-, medium-, and long-term storage of DNA-based data. To achieve this vision, we will exploit bacterial genetic mechanisms that were evolutionarily optimized for billions of years, such as colour-sensitive genetic switches and DNA exchange processes. We have defined two specific objectives to achieve our goal. As a proof-of-concept, we will store a large trajectory file of a molecular dynamics simulation encoded on DNA. Our consortium has six partners from four European countries. One research organisation, two university, and two SMEs will work together to achieve the outlined vision.
Non-CO2 Forcers and their Climate, Weather, Air Quality and Health Impacts (FOCI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Czechia,Israel,United Kingdom,Switzerland,Italy,Sweden,Germany,Finland,Spain,Netherlands
Call: Improved understanding of greenhouse gas fluxes and radiative forcers, including carbon dioxide removal technologies (HORIZON-CL5-2021-D1-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 6470976.25
EU funding (EUR): 6470974.0
Participants: 17
Project status: SIGNED

Indicated area b) While overall the global warming with the causes and global processes connected to well mixed greenhouse gases (GHGs), especially CO2, and their impacts on global to continental scales are well understood with a high level of confidence, there are knowledge gaps concerning the impact of many non-CO2 radiative forcers leading to low confidence in the conclusions. This relates mainly to specific anthropogenic and natural precursor emissions of short-lived GHGs and aerosols and their precursors. These gaps and uncertainties also exist in their subsequent effects on atmospheric chemistry and climate, through direct emissions dependent on changes in e.g., agriculture production and technologies based on scenarios for future development as well as feedbacks of global warming on emissions, e.g., permafrost thaw. In addition to the atmospheric radiative forcing (gaseous or aerosols), albedo changes connected to land-use and land-cover can play a role, depending on the adaptation or mitigation measures included in different scenarios. Thus, FOCI responds to Topic D1-01-01 area b) and its main goal is to assess the impact of key radiative forcers, where and how they arise, the processes of their impact on the climate system, to find and test an efficient implementation of these processes into global Earth System Models (ESMs) and into Regional Climate Models (RCMs), and finally to use the tools developed to investigate mitigation and/or adaptation policies incorporated in selected scenarios of future development targetted at Europe and other regions of the world. We will develop new regionally tuned scenarios based on improved emissions to assess the effects of non-CO2 forcers. Mutual interactions of the results and climate services producers and other end-users will provide feedbacks for the specific scenarios preparation and potential application to support the decision making, including climate policy.

Keywords: radiative forcing,non co2 climate forcers,climate change,climate change impacts,earth system models,regional climate models,chemistry transport models,air pollution emissions,future projection
An Ontological Reconstruction of Gaming Disorder: A Qualitative Meta-Phenomenological Foundation (ORE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Finland
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-06-01
End date: 2027-12-31
Duration (months): 67.0
Total project cost (EUR): 1986991.0
EU funding (EUR): 1986991.0
Participants: 1
Project status: SIGNED

Videogames have become one of the most prevalent forms of cultural production around the world. While their role in teaching and physical culture (“esports”) keeps growing, the health debates on videogame play, or gaming, culminated in 2019 with the World Health Organization’s historical decision to add “gaming disorder” to the International Classification of Diseases. This made gaming, next to gambling, the first and only cultural product with a diagnostic category of addictive use. The above echoes a greater conflict between culture and human development: how can science address potential problems in intensive technology use, when intensive use is also globally integrated into healthy everyday living? To build a foundation for answering this question, I pursue a Meta-Phenomenological Taxonomy of intensive gaming on three levels of lived experience: play, health, and design interaction. The taxonomy is “meta-phenomenological” in the sense that it is structured on the experiences of intensively gaming individuals. These experiences surface in distinct sociocultural contexts in interaction with specific videogame designs, which are the studied meta-areas. This interdisciplinary project is cross-cultural, longitudinal, and qualitative. Participants with and without health problems (n=240) will be followed for three years in South Korea, Slovakia, and Finland. In collaboration with clinical experts, phenomenological interviews are carried out with diaries that include gaming activity logs. The design structures of the videogames in the participants’ lives are analyzed to map out the phenomenological forest of health and play with specific design interactions. The elements are refined into a taxonomy that not only serves as a new foundation for “gaming disorders” but also situates such instances in the colorful spectrum of diverse lives and designs at large—providing grounds for sustainable future theory development at the intersection of health, culture, and design.

Keywords: gaming,media studies,mental disorders,open science,play,technology,videogames
Cellular Homeostasis ANd AGing in Connective TissuE Disorders (CHANGE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,France,Austria,United Kingdom,Germany,Netherlands
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 3046771.54
EU funding (EUR): 2692173.6
Participants: 15
Project status: SIGNED

The increased longevity in developed countries not necessarily goes hand in hand with amelioration of health and quality of life. Musculoskeletal, cardiovascular and neurodegenerative failure are not only hallmarks of the physical and cognitive decline in elderly people, but also represent common traits in several early-onset hereditary connective tissue (CT) disorders. These disorders represent a unique tool for the molecular investigation of such age-related pathologies due to the specific genetic disturbance of cellular homeostasis. The scientific objectives of CHANGE are: (i) to investigate CT disorders to identify key pathways responsible for age-related decline of physiological functions, being aware of gender differences (ii) to learn more about the interdependency of these pathways leading to stereotypic cellular responses including cellular senescence. This knowledge will pave the way for developing innovative treatment strategies for common diseases and frailty associated with ageing. To this end, we will train and establish a network of 10 highly-skilled doctoral candidates (DC) equipped with scientific expertise, transferable skills and societal and environment awareness as a foundation for their future careers. To succeed, CHANGE has built a unique and multidisciplinary network of 7 renowned academic partners and 5 companies (including 2 non-academics as associated partners) working together to train 10 young scientists. The DC network will address the basic biology of ageing from an interdisciplinary perspective, by deeply investigating CT diseases to uncover the pillars of ageing and its multi-systemic signatures. Altogether, CHANGE will provide an integrative map of cellular/extracellular consequences of age-related changes in cartilage, bone, muscle and vasculature as consequences to precocious disease exposure.

Keywords: cartilage,bone,muscle,vascular system,omics technologies,imaging analysis,cellular and animal models,cell homeostasis,cell senescence,drug discovery