Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
RE-IMAGINE-CROPS-HOP – A real-time mobile multimodal positron emission tomography and multiphoton endoscopic technology for REalistic in-field quantitative IMAGING of CROPS, with a HOP-on facility (RE-IMAGINE-CROPS-HOP)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Finland,Portugal
Call: Hop-on facility (HORIZON-WIDERA-2025-03, 2025)
Duration (months): 36.0
Total project cost (EUR): 597500.0
EU funding (EUR): 597500.0
Participants: 2
Project status: CLOSED

The Hop-On addition to the RE-IMAGINE-CROPS project integrates NOVA.id, a partner from Portugal, to strengthen the project’s ambition of transforming sustainable crop management through advanced imaging technologies. Based at NOVA University Lisbon – Faculty of Sciences and Technology (NOVA FCT), NOVA.id brings world-class expertise in plant physiology, biochemistry, and multi-omics analysis to complement and validate the multimodal imaging approaches developed within the project. This contribution will establish a high-throughput multi-omics pipeline to systematically study wheat plants treated with nitrogen fertilisers and/or the Lifeact-Venus PET tracer labeled with 89Zr.Time-resolved metabolomic and transcriptomic profiling, combined with phenotypic and physiological measurements, will be integrated with PET and Multiphoton Endoscopy imaging outputs. This unique dataset will provide new insights into the molecular and physiological mechanisms of nitrogen signaling, enabling data-driven feedback for the design of next-generation tracers, imaging protocols, and precision fertilisation strategies. The impact of this Hop-On action extends beyond science and technology.It will accelerate the optimisation and broader adoption of multimodal imaging solutions, supporting Europe’s goals of reducing fertiliser overuse, protecting ecosystems, and advancing sustainable agriculture. An open-access reference dataset on nitrogen responses in wheat will be generated, reinforcing the European Research Area’s objectives of open science, reproducibility, and innovation. At the same time, the integration of NOVA.id strengthens Portugal’s scientific capacity, and creates long-term benefits through advanced infrastructure, training of early-career researchers, and enhanced participation in transnational projects.This Hop-On addition maximises the scientific, technological, and societal impact of RE-IMAGINE-CROPS and reinforces Europe’s leadership in sustainable precision agriculture.

Keywords: positron emission tomography,imaging,digital imaging,multiphoton endoscopy,digital precision agriculture
PIPAC- The future of cancer surgery; Development, Validation, and Commercialization of a novel drug-device combination for treating peritoneal cancer. (PIPAC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Cancer remains a formidable global health challenge, claiming approximately 10 million lives annually. Despite advancements in cancer treatment modalities like surgery, chemotherapy, and immunotherapy, effectively addressing solid tumors, particularly peritoneal recurrence (PR), post-surgery remains elusive. The recurrence of cancer cells in the peritoneal cavity poses a grave threat, contributing to over a million deaths each year. Existing treatments such as systemic chemotherapy and cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) are limited by low efficacy, high toxicity, and substantial economic burdens. To fill this critical gap, CapnoPharm has developed a transformative solution: Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC). This innovative technology employs the CapnoPen, a certified device for aerosolizing chemotherapy, DNA, RNA, and immunotherapy within body cavities. PIPAC ensures precise drug delivery to the peritoneum, with nearly 100% drug penetration, significantly enhancing treatment efficacy while minimizing systemic side effects. Clinical trials have showcased superior tumor response rates and reduced adverse events compared to conventional therapies. CapnoPharm's solution offers a compelling value proposition, providing targeted drug delivery, enhanced efficacy, cost-effectiveness, and improved patient quality of life. Through the EIC project, CapnoPharm will further develop drug-device combinations for repurposed drugs, focusing on generic drug aerosolization for intraperitoneal delivery. Additionally, the company will undertake comprehensive commercialization and marketing initiatives, including scaling up manufacturing, establishing a dedicated sales team, and ensuring regulatory compliance. These efforts aim to address unmet medical needs in oncology, offering hope for improved survival rates and quality of life for patients with peritoneal metastasis.

Keywords: patient care healthcare system clinical medicine drugs
Transforming Pruning for Smallholder Agriculture with Enhanced Productivity and Working Conditions Using AR and Robotics. (AgRimate)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: Spain,Finland,Italy,Germany,Greece,Ireland,United Kingdom
Call: Enhancing working conditions and strengthening the work force through digital and data technologies – the potential of robotics and augmented reality in agriculture (HORIZON-CL6-2024-GOVERNANCE-01, 2024)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 5000387.5
EU funding (EUR): 4999137.5
Participants: 13
Project status: SIGNED

AgRimate focuses on transforming pruning tasks for small-scale farmers by using Augmented Reality (AR) and Robotics technologies, enriched with Artificial Intelligence (AI). Tackling the significant challenges and labour-intensive aspects of pruning in high-value crops like olive groves and vineyards, AgRimate introduces an innovative and scalable solution. This solution relies on an artificial intelligence module capable of learning from expert human knowledge to address tree pruning challenges. This module extends its functionality to the solution through various tools, from a learning tool that adapts to the user's knowledge to an Augmented Reality solution providing real-time guidance during the pruning process with the human at the centre. It seamlessly integrates with two different robotic solutions, either assisting the user with exoskeletons or autonomously performing tasks with a highly advanced robot. Additionally, AgRimate incorporates a comprehensive assessment tool designed to evaluate the solution's impact, not only on farmers but also on rural communities. This holistic approach aims not only to enhance productivity and resource efficiency but also to improve social inclusiveness and working conditions within the agricultural sector. By forging a consortium of leading research institutions, SMEs, and agricultural stakeholders from across Europe, AgRimate is at the forefront of cultivating sustainable, technologically advanced, and socially responsible farming practices. Ultimately, AgRimate stands as a beacon of innovation in agricultural technology, keenly aligned with the EU's broader goals of digital transformation, environmental sustainability, and socio-economic equity, showcasing a path forward for future farming that prioritizes both yield and community wellbeing.

Keywords: agriculture,tree pruning,augmented reality,robotics solutions,ai capabilities,skilling,well being,working conditions
Evolutionary immunology: using insect models to unravel STING-dependent conserved and innovative antiviral strategies (Evo-immuno)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: France,China
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2396099.0
EU funding (EUR): 2396099.0
Participants: 3
Project status: SIGNED

As we have seen with the emergence of viral pathogens like Ebola, ZIKA and SARS-CoV2, our societies are, and will continue to be, confronted to unknown and perilous viruses. To prepare for this, we propose to explore the diversity of antiviral genes in animals. Important signaling nodes have been conserved throughout evolution and regulate expression of antiviral genes that evolve dynamically in response to viral pressure. Because this occurs in parallel between different lineages, each animal has a unique arsenal of antiviral genes, with a core of conserved genes, but also taxon-specific genes, which represent an unexplored resource of potentially unique antiviral mechanisms. Insects, the largest group of animals, present high potential for such project but lack of information on the viruses infecting most of them prevented broad investigation up to now. Our discovery that the cyclic dinucleotide (CDN) cGAMP triggers a strong STING- and NF-B-dependent antiviral protection in drosophila, provides for the first time a handle to access the repertoire of induced antiviral genes in insects. We will exploit the assets of the drosophila model to address the function of cGAS-like receptors and the CDNs they produce. We will use RNA sequencing of cGAMP-stimulated insects and evolution-guided paradigms to identify among the STING-regulated genes candidates for functional antiviral screens in insect and human cells. Hits will be characterized to understand their mode of action. As proof of principle, we will study the function of Nazo, a fast-evolving STING-regulated gene duplicate in drosophila also strongly upregulated by interferons in bats. Overall, this project will provide a unique evolutionary perspective on the STING pathway and will lay the foundations for exploitation of rapidly increasing genomic data to document original antiviral strategies, with the long-term goal of inspiring innovative therapeutic approaches against viral infections.

Keywords: evolution insects arthropods
Human Ads: Towards Fair Advertising in Content Monetization on Social Media (HUMANads)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Human ads are Internet influencers who earn revenue by creating and monetizing authentic and relatable advertising content for their armies of followers, by relying on business models such as influencer and affiliate marketing. This content often results not only in commercial but also political (hidden) ads, which look the same, are posted by the same persons, are displayed in the same digital space, to the same audiences, and raise the same transparency issues. In this environment, consumers and citizens can no longer distinguish between ads and non-ads, and between commercial and political communications. They are faced with a double transparency problem: (i) human ads have incentives to hide commercial interests, and (ii) platforms have incentives to algorithmically amplify human ads engagement in opaque ways. This reflects a general good faith and fair dealing problem: the social media economy is increasingly based on deceit, which leads to new forms of vulnerability for consumers and citizens on digital markets. Given its complexity and relative novelty, this phenomenon has not yet been the object of sustained academic or regulatory inquiry. HUMANads tackles this comprehensive research gap by exploring why a general European legal regime on fair advertising by human ads on social media platforms is necessary, and what it would entail. First, it articulates new theory of fair advertising in EU consumer law, in the context of content monetization by human ads across commercial and political speech. Second, it gathers evidence relating to business models, advertising prevalence and legal uncertainty through innovative interdisciplinary methods including digital ethnography, comparative law and natural language processing (NLP). Third, it proposes criteria for the assessment of resulting consumer harms, and translates them into a new normative governance model mandating more stringent transparency obligations on social media platforms.

Keywords: influencer marketing,advertising law,natural language processing,platform governance
Activating Learning Paths: Holistic Arts-Based Education and Training for Inclusion and Cultural Awareness (ALPHABETICA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Italy,United Kingdom,Spain,Poland,Portugal,Cyprus,Serbia
Call: Arts and cultural awareness and expression in education and training (HORIZON-CL2-2024-TRANSFORMATIONS-01, 2024)
Start date: 2025-01-01
End date: 2028-06-30
Duration (months): 42.0
Total project cost (EUR): 2978702.5
EU funding (EUR): 2978702.5
Participants: 16
Project status: SIGNED

ALPHABETICA aims to provide effective solutions that allow children and young people at risk of poverty or social exclusion to access arts and arts-based education through co-creative participatory research actions. For some young people, access to ‘art’ is limited; often understood as a luxury or a leisure activity that may feel inaccessible or irrelevant. For others, their creative endeavours might not be recognised from their own perspective, as being ‘art’. ALPHABETICA will carry out 12 pilot actions across 7 European countries aimed at enhancing the transformative effect of active participation in community-driven artistic co-creation activities. Collectively, the research pilot actions cover a range of school settings and out-of-school community settings with children from 3 to 18, as well as young people and adults of various ages. The project is informed by a synthesis of theories of youth participatory action research, Theory of Change, pedagogies of care, love and enchantment, pedagogies of past, present and the imagined future, and the more-than-human approach. This conceptual framework invites a reflexive and in-depth exploration of children and young people’s complex everyday realities, while offering opportunities for creative self-expression and meaning-making, participation, skills-development, and relationship-building. ALPHABETICA will take a transformative approach by: • providing qualitative and quantitative data on attitudes towards and perceptions of arts by children, families, educators and policymakers, • using participatory and caring approaches and pedagogies to provide an evidence-based assessment of the instrumental outcomes of arts-based education, their transformative impact, and their transferability to children and young people’s other life domains, • taking and teaching a caring approach that through arts-based education will sustain a commitment to lifelong learning, • providing evidence-based recommendations for policy action.

Keywords: educational inequalities,youth participatory action research,arts based research,transfer of approach,pedagogies of care
Vascular determinants of cancer cell fate and immune regulation in brain metastasis (METAVASC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-04-01
End date: 2031-03-31
Duration (months): 60.0
Total project cost (EUR): 1499500.0
EU funding (EUR): 1499500.0
Participants: 1
Project status: SIGNED

Brain metastasis (BrM) is one of the deadliest cancer complications, affecting 30-40% of patients. When cancer cells migrate from the primary tumor to the brain, they face the critical challenge of adapting to an entirely new microenvironment. This includes various tissue-resident cell types, a distinct extracellular matrix composition, and more importantly, the challenge of traversing the multiple layers constituting the blood-brain barrier (BBB). The BBB – composed of the endothelial cells, mural cells, and associated microglia and neurons – not only serves as the initial gateway for cancer cells during the early stages of metastatic colonization but also for recruited immune cells, such as cytotoxic T cells, in advanced stages of the disease. The METAVASC project pioneers a novel study of the brain vasculature as a key regulator of both early and advanced stages in BrM, challenging the traditional view of the vascular system as merely structural. By following a multifaceted approach – including niche labeling systems, CRISPR and drug screenings, multiplex immunofluorescence, spatial transcriptomics, and functional studies – this project aims to overcome current limitations in understanding BrM biology from a vascular perspective, addressing two key questions: How do vascular components influence cancer cell survival during the initial stages of BrM (Aim 1)? And how does the brain vasculature regulate immune cell recruitment and activation in later stages (Aim 2)? Although immunocompetent BrM mouse models will be critical to address most of the fundamental questions in this project, the validation process in human samples represents an important milestone (Aim 3), as our ultimate goal is to translate our findings into tangible benefits for patients. In METAVASC, we aim to advance the knowledge of this disease and develop groundbreaking therapies that can transform BrM into preventable and treatable conditions, potentially revolutionizing patient outcomes.

Keywords: brain metastasis,vasculature,tumor microenvironment
The Mechanisms of neuronal silencing in Alzheimer’s Disease – investigation of cellular and network mechanisms in mouse models of β-amyloidosis (MONSil-AD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1482666.25
EU funding (EUR): 1482666.25
Participants: 1
Project status: SIGNED

Alzheimer’s disease (AD) is defined by pathological brain changes, including the accumulation of β-amyloid and tau deposits over decades. In addition, data in human patients and rodent models indicate that neuronal dysfunctions, i.e., altered action potential firing rates, are further hallmarks of AD. Two forms of neuronal dysfunctions exist - neuronal hyperactivity at early stages, followed later by neuronal silencing. The causes of neuronal hyperactivity have been widely studied. However, the mechanisms of neuronal silencing are still incompletely understood, likely due to the high complexity of interdependent brain changes in late AD stages. MONSil-AD aims to unravel the multifactorial pathways leading to neuronal silencing in AD mouse models. My preliminary data indicate that silencing co-occurs with emergent tauopathy, loss of dendritic spines, and decreased presynaptic inputs in mouse models of β-amyloidosis. Moreover, the soluble ectodomain of the microglial ‘triggering receptor expressed on myeloid cells 2’ (sTREM2), which is upregulated in AD, suppresses neuronal activity. Based on these findings, I will investigate whether synaptic uncoupling from the circuit causes the silencing of individual neurons (aim 1) and test if intracellular tau accumulation silences neurons on a cellular level (aim 2). In addition, I will explore the contribution of sTREM2 to neuronal silencing in AD (aim 3) and the interactions between the three mechanisms. To reach the ambitious aims of MONSil-AD, I have implemented cutting-edge in vivo two-photon imaging techniques and developed specialized protocols enabling me, for the first time, to provide a comprehensive picture of the mechanisms leading to neuronal silencing in AD. In addition, MONSil-AD may have direct clinical implications as a basis for the development of an activity-based screening tool for the early non-invasive detection of AD and the development of targeted treatment strategies to prevent neuronal silencing.

Keywords: two photon imaging