Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
New era of guided lens implantation in cataract surgery (Next level cataract surgery)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Luxembourg
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 3271250.0
EU funding (EUR): 2289875.0
Participants: 2
Project status: SIGNED

AkknaTek’s device-based solution is introducing a unique imaging technology to overcome the current hurdles of nowadays cataract surgery. It is designed to offer full control over the lens position at any point of the treatment; for the first time guaranteeing best possible results for every lens implanted. The solution consists of a set of 3 modules which also can be used independently. Pre-operatively, the diagnostic system for patient screening allows detection of capsular bag dislocation, calculates the optimum lens design and eliminates IOLs not suitable for the respective patient to reduce the need for potential re-surgery right from the start. During the surgery, the image-guided system enables real-time monitoring of the IOL placement and computer assisted guidance to ensure accurate placement based on the visual axis. After surgery, the post-operative diagnostic system measures the IOL position and, if needed, helps the surgeon re-align the IOL, as it may move after surgery.

Keywords: cataract surgery
A Youth-centred Preventive Action Approach towards co-created implementation of socially and Physically activating Environmental interventions (YoPAAPE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Netherlands,Denmark,South Africa,Nigeria,Belgium,Portugal
Call: Non-communicable diseases risk reduction in adolescence and youth (Global Alliance for Chronic Diseases - GACD) (HORIZON-HLTH-2022-DISEASE-07, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 3281100.0
EU funding (EUR): 3281100.0
Participants: 10
Project status: SIGNED

BACKGROUND: A vast majority of teenagers do not meet guidelines for healthy movement behaviours (i.e. physical activity, sedentary behaviour and sleep), posing major risks for developing multiple non-communicable diseases (NCDs). Sustainable implementation of lifestyle interventions focused on teenagers is a key challenge. AIM: YoPAAPE aims to tailor, implement and evaluate social and physical environmental interventions for structural improvement in the lifestyle of teenagers (12-18 years) in vulnerable life situations to reduce their NCD risk. APPROACH: YoPAAPE introduces teen-centred, evidence-informed co-creation to tackle the complex real-world challenge of unhealthy lifestyles and health inequalities. In urban environments in HICs (NL, DK) and LMICs (ZA, NG), we will engage teenagers and other key stakeholders in local co-creation communities. Together with academic researchers and local stakeholders, teenagers will take a leading role in 1) mapping the local system, including needs and opportunities; 2) tailoring interventions to the local context; 3) implementing, and 4) evaluating interventions guided by our novel SUPER-AIM framework assessing local Systems, User perspective, Participatory co-creation process, Reach, Effects, Adoption, Implementation, and Maintenance of interventions in an integrated manner. IMPACT: All results will be integrated in an open access YoPAAPE toolbox targeted at researchers, public health practitioners and authorities, policy makers, and citizens. By establishing an infrastructure for teen-centred co-creation including capacity building, mentoring, and participation of teenager health advocates, YoPAAPE will nurture sustainable implementation of teenager-responsive preventive interventions tailored to the local context, improving their agency, movement behaviours and wellbeing, ultimately halting the rise of NCDs and associated healthcare costs.

Keywords: physical activity,movement behaviour,health promotion,participatory action research,co creation,implementation
Metabolically Enhanced Lactic Acid Bacteria for Boosting Cancer Therapy (MELAB)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-10-01
End date: 2027-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Inter-individual variation in cancer therapy responses is significant, with a substantial fraction of patients not responding to treatment. This exposes non-responders to harmful side effects without benefit and results in vast resources being spent on eventually ineffective treatments. A key factor behind this variability is differences in microbiome composition and metabolism. However, translating microbiome-cancer research into live bacterial therapies that modulate the microbiome is challenging due to its complexity and heterogeneity. This project addresses this challenge using safe, robust, metabolically enhanced lactic acid bacteria capable of delivering therapy-boosting metabolites in the gut. We focus on metabolites naturally produced by gut bacteria that have been shown to enhance the efficacy of chemotherapy. The engineered bacteria will function as live biotherapeutics, ensuring the targeted delivery of metabolites directly in the gut and thus achieving physiologically beneficial pharmacokinetics. Our approach is distinct from other microbiome therapies due to its clear mechanism of action and the use of a unique platform developed in the ERC project ModEM. It enables rapid metabolic enhancement without genetic engineering, thereby reducing regulatory hurdles and accelerating market entry. Overall, the MELAB project aims to translate core findings from the ModEM project into a novel therapeutic adjuvant with the potential to benefit cancer patients by increasing therapy response rates.

Keywords: microbiome,cancer,live biotherapeutics
Large-Scale Electrosynthesis of Borylated Azines (B_ELECTRO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-01-01
End date: 2025-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

'The Nobel prize-winning Suzuki-Miyaura cross-coupling involves the palladium-catalysed coupling of a borylated molecule with an aryl halide and is the 2nd most used process by the pharmaceutical sector. Azines are small-molecules integral to discover and manufacture pharmaceuticals and agrochemicals. Using azines in Suzuki-Miyaura cross-coupling reactions represents the ideal solution to introduce these important motifs in discovery molecules but here is where the problems come: 1. There is currently very limited way of borylating azines. 2. Borylated azines, especially the ones containing a boron vicinal to the N-atom, are highly unstable. We urgently need chemical methods delivering borylated azines in a fast and cost-effective manner and that can then be employed in Suzuki-Miyaura cross-coupling reactions. As part of our ERC-2018-StG NEBULAR, focused on the development of novel photochemical strategies in radical chemistry, we recently identified a strategy that generates boryl radicals and provides far greater capability over any other method to both prepare and utilize borylated azines in modular fragment synthesis. B-ELECTRO aims to make the synthesis of our borylated azines workable on large scale and thus attractive to pharma and agro industries. This program provides a unique opportunity for the commercialization of our borylated materials and their utilization by end-users, thus providing innovative chemistry solutions and long-lasting impact to pharmaceutical and agrochemical industry and eventually our society.
A novel theory of human cortical microcircuit function: Dedicated neuronal networks for fast cellular and synaptic computation (FASTHUMANNEURON)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

How human neuronal circuits are organized to produce human cognition is poorly understood. We recently showed (Nature, 2021) that human neocortex contains neuron types not found in other mammals. My preliminary data show that large, human-specialized transcriptomically-defined cell types (t-types) have surprisingly fast processing of synaptic input to action potential output properties. Other human t-types show much slower input-output properties more akin to average mammalian neurons. These fast human-specialized t-types are selectively vulnerable in prevalent human brain disorders with cognitive decline. Mechanisms of fast input-output processing are unknown. We also do not know whether fast-processing neuron t-types form preferential synaptic networks dedicated to fast cortical processing, increasing cortical computational power to support human cognition. Here, I will test this novel concept addressing four fundamental questions: What mechanisms drive fast cellular input-output properties? What mechanisms underlie non-linear dendritic processing of synaptic input? How is coupling between distal dendritic synapses and soma controlled? Do human neuron t-types with fast input-output properties form preferential synaptic networks? These questions can only now be answered with our recent transcriptomic, morpho-electric Patch-seq analysis of adult human neuron t-types. Combined with dendritic and multi-patch recordings, molecular interventions, photonic approaches, and computational modeling, I will provide an unprecedented quantitative understanding of fast cellular computation mechanisms in human cortex supporting human cognition. First preliminary data suggest that biophysical properties of human-specialized neuron t-types and synapses are distinct. Understanding human cortical organization of fast input-output neurons provides a novel framework to understand how selective loss of neuron t-types in human brain disorders gives rise to cognitive decline.

Keywords: human neurons,synapses,dendrites,neuronal computation,single cell rna sequencing,cortical microcircuits
A novel, integrated approach to urban water quality monitoring, management and valorisation (UrbaQuantum)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Innovation actions
Countries involved: Cyprus,France,United Kingdom,Germany,Greece,Spain
Call: Holistic approaches for effective monitoring of water quality in urban areas (HORIZON-CL6-2024-ZEROPOLLUTION-02, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 5646808.4
EU funding (EUR): 4999167.25
Participants: 19
Project status: SIGNED

Conventional, fragmented approaches to urban water management are no longer adequate as they have failed (or are likely to fail) from the perspective of cost effectiveness, technical performance, social equity, and environmental sustainability. A system-wide paradigm shift is required towards the formation of a synergic urban-water relationship. Integrated Urban Water Management (IUWM) provides a framework for interventions over the entire water cycle which simultaneously advance water resources security, enhance the quality of life, optimise economic growth, maintain ecological balance and improve water systems’ resilience to climate change. Effective implementation of IUWM though must overcome some important challenges before these benefits can be realized. UrbaQuantum sets clear Key Strategic Objectives (KSOs) through which the main challenges will be addressed, leading to effective implementation of IUWM. In the heart of the project are the diversified, real-world use cases. KSO #1: Develop sensing strategies & novel sensors for pathogens detection KSO #2: Develop novel sensors for microplastics and key chemical contaminants of emerging concern KSO #3: Develop new models and approaches for sewer overflows and sewer/surface water interaction KSO #4: Assess sources and pathways of water pollutants via urban stormwater KSO #5: Support water utilities operators and policymakers in planning (long-term) and operational (short-term) tasks through the integration of an Urban Water Platform (UWP) for decision-support KSO #6: Validate and demonstrate the approach and tools in real-world conditions KSO #7: Develop a framework for the effective application of the UrbaQuantum approach. Widely disseminate results & cooperate with the EU-scale stakeholders

Keywords: decision support systems,pathogens sensing,microplastics,chemicals of emerging concern,cso,water modelling
InteractionSeeds (InteractionSeeds)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Coordination and support actions
Countries involved: France,Sweden,Spain,Belgium,Greece
Call: Fostering knowledge valorisation through societal and cultural interactions (CSA) (HORIZON-CL4-2023-HUMAN-01, 2023)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 1109547.22
EU funding (EUR): 983118.86
Participants: 6
Project status: SIGNED

InteractionSeeds partners have joined forces to facilitate and connect different worlds (industry, citizens, arts) through the development of a repository of 50+ locally proven and easy to replicate interaction schemes. The repository (WP1), expected to turn into a platform at exploitation stage, will ultimately take the form of a two-sided platform connecting a network of stakeholders: -Providers of societal and cultural interaction schemes, that have proven their value and that have a potential for replicability beyond their geographic range; -Organisations having missions in fostering connections between industry, society and art willing to explore, adapt and test locally proven interaction schemes. During the project, 20+ test cases of interaction schemes will be implemented (WP4), to support R&I knowledge valorisation. These test cases will notably involve R&I stakeholders previously engaged and trained (thanks to the development of a training kit - WP2). Protocol for the test cases implemented will be designed and adapted to the local context in WP3. Finally, a set of recommendations (WP4) on why and how to facilitate the implementation of new test cases. These recommendations will be largely disseminated to 100+ R&I representative stakeholders (such as clusters, EDIH, incubators etc.) to support the project's replicability and large use of the repository.

Keywords: art thinking artificial intelligence knowledge valorisation innovation citizen engagement interaction schemes
Undeserving of the Union: The American Idea of the 'Underclass' in Europe, 1992-2011 (UCinEU)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-01
End date: 2029-01-31
Duration (months): 35.0
Total project cost (EUR): 384484.02
EU funding (EUR): 384484.02
Participants: 2
Project status: SIGNED

The aim of this project is to write a cultural history of the different ways in which the American construct of the ‘underclass’ was exported to different European national contexts in the twenty years following the Maastricht Treaty. Through a web of transatlantic relations, the concept was modified and adapted to those segments of the population that were hit the hardest by the ongoing processes of deindustrialisation, thus impacting the way in which Europeans problematized poverty and marginalisation. Academic writing, journalism and politicians’ speeches became the vectors of a gradual change that involved public policy at all levels, as well as national common sense. The project aims at verifying the hypothesis that the importation and adaptation of the concept of ‘underclass’ was functional to the differentiated implementation of neoliberal policies in different but interrelated contexts. It focuses such exploration on Italy, Germany and the United Kingdom. The choice of making it as cultural history is based on the premise that the magnitude of this shift in policy and mentality can only be gauged through an interdisciplinary methodology integrating analytic tools from history, sociology and cultural studies. Thus, as a scholar of literature and culture, I have chosen as my prospective supervisors two sociologists. Should my application be successful, I would be working with Professor Fabio Perocco at the Ca’ Foscari University of Venice, who has long worked on the comparative sociology of inequality, and with Professor Loïc Wacquant at the University of California, Berkeley, whose symbolic-sociological analysis of various aspects of neoliberalism has informed much of the theoretical frame of this project, and who has done extensive work on the history of the concept of ‘underclass’ in the United States.

Keywords: underclass deindustrialisation european union germany united kingdom italy neoliberalism poverty marginality
Systematic analyses and rational engineering of fast CO2 fixation pathways in living cells (FASTFIX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499980.0
EU funding (EUR): 1499980.0
Participants: 1
Project status: SIGNED

Biological CO2 fixation is the primary process responsible for biomass and food production and a key player in the atmospheric CO2 balance. Almost all biological CO2 fixation is caried out by a single pathway: the Calvin cycle. Despite the dominance of this pathway in nature it seems relatively inefficient due to high energy costs and poor enzyme kinetics. An exciting option to improve this efficiency, is the exploration of potentially more efficient synthetic CO2 pathways. However, a key challenge to identify promising synthetic CO2 fixation pathways is the limited availability of kinetic data on relevant enzymes. In addition, kinetic data are usually measured in vitro and hence not always representative for the performance in living cells. In FASTFIX, I will develop and use a novel method to quantify kinetics of enzymes within living cells. I will do this by making the growth rate of engineered Escherichia coli cells directly dependent on the kinetics and levels of the enzymes of interest. By measuring the growth rates and enzyme levels by absolute quantitative proteomics, the in vivo kinetics of the enzymes can be determined. This approach will be used to generate a complete overview of the kinetics of enzymes involved in promising synthetic CO2 fixation pathways. This will enable an unprecedented systematic analysis of the kinetics of synthetic CO2 fixation pathways. Based on this analysis I will select the most promising pathway design. Enabled by the in vivo kinetics data I will then employ a novel forward-engineering method to effectively engineer and demonstrate the performance of the full pathway in E. coli. The realization of a fast, energy-efficient synthetic CO2 fixation pathway in living cells will be a major milestone. The anticipated results will be promising for efficient CO2-based biotechnological production, and in the longer-term may increase agricultural yields and help to more efficiently mitigate humanity’s CO2 footprint.

Keywords: metabolic engineering microbial biotechnology carbon fixation synthetic metabolism