Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A reference big data platform implementation and AI analytics toolkit toward innovative data sharing-driven energy service ecosystems for the building sector and beyond (BEYOND)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Innovation actions
Countries involved: Spain,Spain,Cyprus,Finland,Serbia,Greece,Croatia,Greece,France
Call: Big data for buildings (H2020-LC-SC3-EE-2020-1, 2020)
Start date: 2020-12-01
End date: 2023-11-30
Duration (months): 36.0
Total project cost (EUR): 5220816.96
EU funding (EUR): 3999948.0
Participants: 15
Project status: SIGNED

BEYOND brings forward a reference Big Data Management Platform, on top of which an advanced AI analytics toolkit will be offered allowing for the delivery of derivative data and intelligence out of a blend of real-life building data and relevant data coming from external sources (batch and real-time). The Analytics Toolkit will enable the execution of a wealth of descriptive-predictive-prescriptive analytics on the basis of pre-trained algorithms focusing on Personal Analytics (consumer behaviour, comfort and flexibility profiling), Industrial Analytics (Energy Performance, Predictive Maintenance, Forecasting and Flexibility analytics), along with Edge Analytics towards intelligent real-time automated control of building assets. The BEYOND Big data platform and AI Analytics Toolkit will be associated with novel data (intelligence) sharing mechanisms that enable the integration of value chain stakeholders (building and market actors), thus allowing the latter ones to gain the opportunity to acquire building data & advanced analytics and build their own applications and solutions, towards (i) providing innovative energy services to the building sector, while (ii) at the same time improving their business operations and increasing their business processes and operations (de-risked EPC, informed policy planning & infrastructure sizing). To achieve this degree of intelligence and optimization, BEYOND will leverage data, primary or secondarily related to the building domain, coming from diverse sources (data APIs, historical, sensor / IoT, weather and market data, the EU Building Stock Observatory, open building data hubs) integrated to the BEYOND Platform to enable data exchange in an interoperable and standards-based manner. BEYOND will be validated in 4 large-scale demonstrators (EL, ES, FI, RS) involving (i) data collection from diverse building typologies, data sources, building systems and devices, and (ii) data (intelligence) sharing with various market actors.

Keywords: bd reference architecture,real time data analytics,artificial intelligence,energy services,interoperability,data sharing,data driven business models,standardization,data hub integration
Cold atmospheric plasma treatment for effective cancer cell apoptosis (CAP-CANCER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Cyprus
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 163648.8
EU funding (EUR): 163648.8
Participants: 1
Project status: CLOSED

Cold atmospheric plasma (CAP) has shown promise in minimally invasive surgery by selectively treating cancerous cells with little or no damage to healthy cells. The selective destruction of cancerous cells can be used to aid and enhance current cancer treatments and can also be the cure for forms of inoperable cancer. The selective treatment can be obtained by using the plasma to induce cell apoptosis, in which the cell self-destructs in a tightly controlled way without causing inflammation in the surrounding tissue. One of the major challenges of this research is that the exact mechanism of plasma induced apoptosis is not well understood. The fellow proposes to test the hypothesis CAP builds up electric fields across the cell membrane that cause electroporation for the cancerous but not the healthy cell because they have different electrical and physical properties. Electroporation allows for the penetration of reactive oxygen species (ROS) into the cancerous cell causing apoptosis while leaving the healthy cells intact. The fellow will develop numerical simulations to allow the study of cell surface electric fields and generation of ROS will explore the parameter space in which the electroporation and therefore apoptosis will be induced only for the cancerous cells. During his secondment the Fellow will perform experiments by applying CAP onto two Breast cell lines: MDA-MB-231 (cancerous) MCF-12F (healthy) and will use flow cytometry to measure electroporation and apoptosis. The results of this research will elucidate how CAP interacts with tissue and under what conditions it causes apoptosis. This will allow us to get closer to an actual medical device utilizing CAP to treat cancer on patients. The fellow will gain scientific skills in cell culture handling, storing, preparation, plasma sources and characterization and complementary skills and will reach a position of professional maturity and leadership in research and development in Europe.

Keywords: cancer,tumour,cell necrosis,plasma treatment,numerical simulation
A SYSTEMATIC APPROACH FOR INSPIRING TRAINING ENERGY-SPATIAL-SOCIOECONOMIC SUSTAINABILITY TO PUBLIC AUTHORITIES (INTENSSS-PA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Spain,Italy,Italy,Italy,Greece,Slovenia,Greece,Slovenia,Greece,Greece,Latvia,Latvia,Netherlands,Denmark,Denmark
Call: Enhancing the capacity of public authorities to plan and implement sustainable energy policies and measures (H2020-EE-2015-3-MarketUptake, 2015)
Start date: 2016-02-01
End date: 2018-07-31
Duration (months): 30.0
Total project cost (EUR): 1697381.0
EU funding (EUR): 1697381.0
Participants: 18
Project status: CLOSED

INTENSSS-PA will support public authorities to integrate the energy theme into spatial planning and regional physical and socioeconomic landscapes. To achieve this objective INTENSS-PA will provide human and institutional capacity building to public authorities and to the wider network of private and public actors related to energy and regional planning by implementing the Living Lab concept, i.e. an innovative environment of co-creation. Specifically, a network of seven Regional Living Labs (RLL) within the seven different Countries/Regions that participate in the consortium (Thessaly-Greece, Calabria-Italy, Castilla y Leon- Spain, Association of Municipalities-Slovenia, Groningen-Netherlands, Triangle-Denmark and Zemgale-Latvia), will be created. Involving public authorities, private and civil society actors, the RLLs are focused on improving and designing a shared and integrated sustainable energy planning concept and on applying it in order to develop seven sustainable energy plans, i.e. one for each Region. The overall approach will involve learning sessions and experiential projects alongside intense networking. Communication and exploitation activities are envisaged including national Roadshows and a survey with policy makers. It is expected that over 200 people participate in the capacity-building activities performed within the RLLs network, while the stakeholders and policy makers informed on the project results and activities will exceed the 1000 individuals. The project objectives are completely inline with topic EE07’s scope, since it considers innovative capacity building activities to public authorities for integrated energy planning through the establishment of a network of RLLs, i.e. of an ecosystem that stakeholders bring their own specific wealth of knowledge and expertise to the collective, helping to achieve boundary spanning knowledge transfer. Special consideration will be provided on planning requirements deriving from 27/2012/EU Directive.

Keywords: regional living labs concept,capacity building,multilevel governance,public authorities,experiential learning,integrated sustainable energy planning,institutional frameworks,co creation ecosyst
Distinct Infection Dynamics and Ecological Success among Closely Related Marine Cyanophages: Why the Differences? (PhageDiff)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 2162296.0
EU funding (EUR): 2162296.0
Participants: 1
Project status: CLOSED

Viruses are extremely abundant in the oceans and majorly impact the marine ecosystem by influencing the abundance, diversity and evolution of their hosts. However, our understanding of marine viral physiology and ecology among different members of the virus community is conspicuously lacking. Preliminary data using a newly developed molecular method revealed drastic differences in field abundances of two subtypes of T7-like podoviruses that infect marine cyanobacteria. Moreover, these subtypes displayed large differences in infection properties in laboratory studies. The main objective of this proposal is to gain a deep understanding of the genetic basis for the physiological differences in infection dynamics among closely related T7-like cyanophages that infect the globally important marine cyanobacteria, Synechococcus and Prochlorococcus, and to ascertain the ecological consequences of these physiological differences. We hypothesize that a small set of genes, beyond the core replication and morphogenesis genes, differentially impact the dynamics of the infection process which, in-turn, defines the niche occupied by discrete members of this virus family. Our specific objectives are to identify the genes responsible for the physiological differences and determine their impact on infection dynamics. This will be achieved through the development of a phage gene inactivation system and the comparison of infection properties of mutant and wild-type phages. Furthermore, using our new molecular field method, we will assess the distribution patterns of different subtypes of T7-like cyanophages from within the mix of all viruses in the oceans. The unique combination of innovative molecular methods with physiological experimentation and ecological sampling will provide significant insight into both the biological functionality behind the diversity within an ecologically relevant phage family and the selection pressures that have led to their diversification and evolution.

Keywords: cyanobacteria,prochlorococcus,synechococcus,phage,virus,psba,physiology,diversity
Decrypting Mycobacterium cytochrome P450 (CYP) physiological functions by testing hypotheses emitted form large-scale comparative genomics analysis (deCrYPtion)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2022-03-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

More than 190 species belong to the Mycobacterium genus. Among those, several are pathogenic to human and animals. The high number of human lives lost and the economic consequences of livestock infection are important incentives in the control and eradication of the responsible organisms. M. tuberculosis, one of the causative agents of tuberculosis (TB), is the most problematic representative: in 2016, 1.7 million deaths worldwide have been attributed to TB. Like for other infectious organisms, antibiotic resistances have appeared in Mycobacterium. Thus, there is a fundamental need to develop new antimycobacterial drugs. The inhibition of enzymes belonging to the Cytochrome P450 (CYP) protein family has been shown to suppresses the growth of several Mycobacterium species, making CYPs targets for drug development. Unfortunately, most CYPs are considered orphan: proteins for which no physiological function is known. The deCrYPtion action aims to define the physiological function of a selected set of mycobacterial CYPs. It will prove determinant in the development of new antibiotics. I will perform a large-scale comparative genomics analysis of the CYPs encoded by Mycobacterium species, in order to define orthologous groups and identify, for each, conserved partners and pathway context. This approach is extremely powerful (even if not frequently used) and allow to propose physiological functions, based on the information obtained. Specific CYPs to be characterized will be selected based on a set of stringent considerations, including their potential as drug targets. A preliminary analysis illustrates the approach that will be used. A combination of complementary biochemical, genetics and physiological experiments will be performed to validate the hypotheses generated. deCrYPtion will be undertaken within the Centre for Cytochrome P450 Biodiversity, under the supervision of Prof Steven Kelly, at Swansea University (Wales, United Kingdom).

Keywords: enzyme of unknown function,cytochrome p450,orphan,mycobacterium,tuberculosis,smegmatis,azole,antibiotic,drug,resistance,comparative genomics,sequence similarity network,hypotheses
IMaging-based CUSTOMised EYE diagnostics (IMCUSTOMEYE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Ireland,Germany,Spain,Spain,Poland,Switzerland,Switzerland,United Kingdom,United Kingdom,United Kingdom
Call: Photonics KET 2017 (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 6426373.33
EU funding (EUR): 5931669.13
Participants: 12
Project status: CLOSED

Prevalent eye diseases, such as glaucoma, keratoconus, refractive errors, cataract, myopia and presbyopia, affect millions worldwide, and only in Europe represent over €20 billion annual cost to society. Current screening tools rely on morphological biomarkers based on corneal shape and optics, yet differences in biomechanical properties underlie and precede disease development (i.e. keratoconus, ectasia risk) or affect standard markers (i.e. intraocular pressure in glaucoma). IMCUSTOMEYE will develop new diagnostic paradigms for these vision-threatening conditions, with a direct impact on their treatment. We will deploy new compact, easy-to-use, label-free non-invasive imaging-based instrumentation for direct measurement of corneal biomechanical properties in patients. The technology is based on imaging concepts brought from other disciplines into ophthalmology and, for the first time, applied in patients in vivo. Dynamic corneal imaging based on air-puff stimulated Optical Coherence Tomography corneal deformation and acoustic stimulated phase sensitive and nanosensitive Optical Coherence Tomography corneal vibrography will be coupled to corneal mechanical models to estimate corneal elasticity and viscoelasticity parameters (isolated from other factors). Corneal biomechanical properties will be used as biomarkers for in-depth diagnosis of keratoconus and ectasia risk, and to provide accurate estimates of intraocular pressure in glaucoma diagnosis. Clinical validations in ophthalmology hospitals will demonstrate the diagnostic and treatment predictive potential of the customised optical and biomechanical eye models from patient-specific enabled by the new technology. IMCUSTOMEYE will contribute to more effective, customised treatment of eye diseases and to reinforce industrial leadership in the area of diagnostic imaging in ophthalmology.

Keywords: eye disease,ophthalmology,corneal biomechanics,optical coherence tomography
Steering organic farming transition (SOFT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

A key challenge for sustainable intensification of agriculture is to reduce hunger and poverty by producing increasing amounts of food, feed, and bioenergy for a growing world population, but with minimal loss of biodiversity and ecosystem functioning. In intensive conventional farming systems yields are high, but soil biodiversity and ecosystem functioning are often reduced, and soil food webs are simplified. Organic farming provides a more environmentally sustainable alternative, but it typically produces lower yields, particularly in early years after conversion. In SOFT (Steering Organic Farming Transition), I will test if soil inoculation may be a promising tool to speed up the transition from high-yield conventional to high-yield organic agriculture and can help to overcome ‘soil legacy effects’ due to impoverished soil communities. First, I will use a chronosequence of farmers’ fields throughout The Netherlands that have been converted from conventional to organic farming to study the role that the structure of soil networks may have in soil functioning. Then, I will use soil collected from these sites to test the potential of soil inoculation to aid the transition of soil communities and coupling of soil networks in organic farming systems. By revealing the potential of whole soil inoculation to regenerate soil networks, and how soil networks relate to functioning in agroecosystems, SOFT will be a ground-breaking advancement compared to current efforts to understand the transition from conventional to organic systems and may serve as a baseline for downstream manipulation studies in which certain soil communities may be engineered as inoculants to steer and speed-up this transition. Taken together, SOFT will contribute to establish new management practices that may help to shorten the transition period from conventional farming to a more organic type of farming that maintains high crop yields while having less negative environmental impacts.

Keywords: soil inoculation,organic agriculture,sustainable transition,soil biodiversity,ecological networks
Unravelling Discoloration Mechanisms of Red Organic Pigments in Historical Art Works. (RED-OPEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

An important issue encountered in the historical artworks is the fading of the original colors because of their strong light sensitivity, infamously leading to the discoloration of masterworks even within an artist’s lifetime. This phenomenon is clearly evidenced in many paintings of 19th century European impressionist artists, such as van Gogh, in particular when Organic Red Pigments (ORP) have been used. The identification of these ORP in historical paintings remains a main challenge because of (1) the generally low concentration of the original pigment remaining after an aging period of ca. 100 years, (2) the scarcity of the paint micro samples available for analysis and the difficulty of obtaining additional ones and (3) the complexity of degradation behavior in the presence of oxygen, inorganic semiconductor pigments, binding media or varnish. The objective of the RED-OPEN project is to develop a multi-analytical approach based on mass spectrometry and spectroscopic techniques (A) to understand their discoloration mechanism and (B) to identify their breakdown products, even if the original molecules are no longer present in the artworks. The successful completion of RED-OPEN will have a major impact in the understanding of the original artwork’s appearance and will provide comprehensive and detailed knowledge of the progressive changes throughout the painting’s history. RED-OPEN will generate knowledge that will help conservators and conservation scientists to understand the causes of discoloration and formulate mitigating actions, preserving invaluable art for future generations and further proposing a digital reconstruction of its originally intended appearance.

Keywords: organic pigments,conservation science,cultural heritage,high resolution mass spectrometry,electron paramagnetic resonance,ambient mass spectrometry