Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Regulation of Processing Body Composition, Function and Fate during Different Stresses at Endoplasmic Reticulum-Membrane Contact Sites (PBStressERMCSs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

One of the first responses to eukaryotic cellular stress is the formation of cytoplasmic granules like processing bodies (PBs) and stress granules (SGs). PBs are membrane-less structures that are dynamic in their assembly/disassembly and composition depending on the type of stress that they encounter. While glucose starvation is the main stress applied to study PB formation and dynamics, much less is known about PBs under other stresses, especially endoplasmic reticulum (ER) and mitochondrial/lysosomal stresses. We propose to study the formation, content and dynamics of PBs under ER and mitochondrial/lysosomal stresses, together with their turnover (autophagy/dissolution) during stress recovery. I plan to use pharmacological and acute genetic interventions to induce stresses. PBs will be purified according to the established protocol in the laboratory, which enables subsequent Liquid chromatography-mass spectrometry (LC-MS) analysis for proteins and RNA-sequencing for the RNA content. Probing stress response further, we will also perform total RNA-sequencing and Ribosome-profiling. The fate of specific sets of mRNAs will be determined by FISH-IF and RNA decay analysis, thereby identifying the signals effectuating PB localization and fate (storage or decay) during ER and mitochondrial/lysosomal stress. The study will be extended to check conservation of PB stress response in mammalian cells. The proposed research will provide a holistic view on the pathways that are up- or down-regulated during ER and mitochondrial/lysosomal stress, the identification of common pathways between the different stresses and PB -mRNA and protein- turnover. This project will be of high impact in the fields of cancer, cell, and neuro biology.

Keywords: rna decay,endoplasmic reticulum membrane contact sites er mcss,processing bodies,organellar stress response,autophagy
Prediction of Air Pollution in Latin America (PAPILA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Argentina,Germany,Sweden,Bolivia, Plurinational State of,Colombia,Norway,Finland,France,France,France,United States,Netherlands,Chile,Venezuela, Bolivarian Republic of,Brazil,Mexico
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-01-01
End date: 2023-10-31
Duration (months): 70.0
Total project cost (EUR): 999000.0
EU funding (EUR): 999000.0
Participants: 20
Project status: SIGNED

The overall objective of the PAPILA project (Prediction of Air Pollution in Latin America and the Caribbean) is to establish a sustained network of partners with complementary expertise, which will develop and implement an analysis and forecast system for air quality with downscaling capability for Latin America and the Caribbean region (LAC region), and assess the impact of air pollution (background and peaks) on health and on the economy. This forecast system will help decision-makers improve air quality and public health, and avoid the occurrence of acute air pollution episodes, particularly in urban areas. The project combines an ensemble of state-of-the-art models, high-resolution emission inventories, space observations and surface measurements to provide near real time forecasts and analysis of regional air pollution in the LAC region. To reach this objective, the project will bring together an interdisciplinary team of scientists from Europe, Latin America (Argentina, Bolivia, Brazil, Chile, Colombia, Mexico, Venezuela) and the Caribbean (Puerto Rico), and foster synergies between the groups involved in research and service activities. The project will co-develop with users and other stakeholders several products and services of importance for the LAC region. An important objective of the project is to make use of complementary competence to develop innovative ideas, to established sustained partnerships between research groups, to transfer information to the public, to develop educational activities and to create a dialogue with interested stakeholders. Societal impacts, specifically on human health, on crop production, on ecosystems, on the mountain snow cover and on the hydrological cycle as well as the economic benefits of mitigation policies will be assessed. Finally, the planned activities will provide the basis for sustained capacity building actions.

Keywords: chemical weather,chemical climate,air quality forecasts,impacts on health and agriculture,air quality mitigation,dialogue with stakeholders,education,particulate matter,ozone,emissions
Revealing the contribution of liver macrophage populations to NASH in insulin resistance (MacinNASH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1999781.0
EU funding (EUR): 1999781.0
Participants: 1
Project status: TERMINATED

Non-alcoholic steatohepatitis (NASH), the most common chronic liver disease worldwide, is an unmet medical need with no approved therapies and debilitating consequences for patients. Obesity-associated insulin resistance is a high-risk factor for the development of NASH. The prevailing paradigm is a multiple hit process, whereby lipid accumulation in the liver of obese patients leads to oxidative stress and increased production of inflammatory cytokines by macrophages. However, my research group's comprehensive investigations in mice and humans have revealed that liver macrophages (LMs) contribute to insulin resistance and oxidative stress independently of their inflammatory status. I thereby propose that LMs predispose insulin resistant patients to NASH independently of their inflammatory status. In this ambitious multidisciplinary project, we will use a novel platform encompassing multiple single cell and in situ omics technologies tailored by my research group to characterize the phenotype of LM populations in healthy individuals and insulin resistant patients with or without NASH. We will strengthen this approach with functional validation in animal models as well as human liver organoids using a patented technology that I have developed to specifically manipulate gene expression in macrophages. We will then decipher how hepatic insulin resistance creates a spatiotemporal environment facilitating NASH. My group's unique access to patient material combined with cutting-edge methodologies to reveal the phenotype of single LMs provides an exceptional starting point from which to identify genes and pathways involved in the development of NASH in obese insulin resistant patients. This project will set the stage for a paradigm-shift in studying and treating life-threatening liver diseases.

Keywords: liver,macrophages,insulin resistance,obesity,non alcoholic steatohepatitis
Small Ruminant Technology - Precision Livestock Farming and Digital Technology for Small Ruminants (SmaRT)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Coordination and support actions
Countries involved: Estonia,Ireland,Israel,Italy,Hungary,Norway,France,France,France,France,France,France,United Kingdom,United Kingdom
Call: Thematic networks compiling knowledge ready for practice (H2020-RUR-2020-1, 2020)
Start date: 2021-01-01
End date: 2024-09-30
Duration (months): 45.0
Total project cost (EUR): 1997214.75
EU funding (EUR): 1997214.25
Participants: 14
Project status: SIGNED

Rural economies across Europe, and associated countries, heavily rely on small ruminant (SR) systems, particularly in areas unsuitable for other alternative agriculture purposes. Despite recent advances in precision livestock farming (PLF) and digital technologies (DT) to improve farm practices, the SR sector shows a slow rate of practitioners’ uptake. There is a need to improve awareness and knowledge transfer on the potential of technology applications and return on investment. Sm@RT aims to improve understanding, awareness and uptake of the different technologies currently available to the SR sector, and further to facilitate ‘solutions to needs’ and identification of technology gaps. The project will develop a long-term, self-sustainable European/International network to encourage the use of PLF and DT across the SR sector. The network will stimulate knowledge exchange and cross-fertilisation amongst a wide range of stakeholders, including drawing upon the valuable input and knowledge of farmers to farmers, to help increase uptake across the industry. Sm@RT will focus on the use of PLF and DT across all types of sheep and goat management systems and environments. Sm@RT will use an original interactive transdisciplinary and multi-actor approach, relying on well-equipped demonstration farms (‘digifarms’) and innovative commercial farms to foster exchanges with the SR industry. This iterative step-by-step approach implicates relevant actors at the right level in the knowledge exchange process, thus boosting dissemination in a trusting environment and creating a dynamic to motivate IT companies to propose suitable PLF and DT solutions for the SR sector. Sharing of experiences across both local and transnational levels will create wider opportunities to collect and exchange knowledge, thus enabling Sm@RT to communicate and disseminate information and guidelines widely, increasing efficiency and sustainability of SR farming in Europe and beyond.

Keywords: precision livestock farming,digital technology
Coulomb Engineering of Quantum States in Matter (CoulENGINE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany,Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-04-01
End date: 2027-03-31
Duration (months): 60.0
Total project cost (EUR): 1999627.0
EU funding (EUR): 1999627.0
Participants: 2
Project status: SIGNED

Key phenomena in condensed matter are determined by the properties of the electronic states, strongly motivating the development of strategies for their artificial design. In semiconducting solids, heavily studied from fundamental and technological perspectives, electronic structures are currently defined using strong perturbations of the materials such as tuning the chemical composition, changing the geometry, or applying external fields. Traditional concepts, however, inherently rely on modifying single-particle properties of individual electrons, while the influence of many-particle interactions has been largely neglected in the context of bandstructure engineering so far. In addition, conventional methods start to approach intrinsic barriers in today’s technology, driving an intense search for fundamentally novel concepts. Here, I propose to explore an alternative pathway to design and manipulate electronic states in matter that is exclusively based on many-particle interactions between electronic excitations mediated by Coulomb forces. These are exceptionally strong in two-dimensional (2D) semiconductors with a major impact on the energies of the electronic states, and are highly sensitive to the dielectric surroundings. Using layered heterostructures I intend to show how the dielectric environment of a 2D semiconductor can be tuned on ultrafast timescales by pulsed optical injection to manipulate electronic states via proximity screening. Similarly, external screening will be used to study how the geometry of proximate objects can be imprinted on the electronic structure of a 2D layer, creating dielectrically defined zero-, one-, and two-dimensional potentials in one unified system. Ultimately, the realization of rapidly tunable electronic quantum states through dielectric environment will offer novel, versatile experimental platforms for fundamental many-body physics research and establish a new approach for electronic structure engineering on the nanoscale.

Keywords: nanoscale materials,spectroscopy,two dimensional semiconductors,interactions at surfaces and interfaces,electronic structure engineering
MMT will deliver a language independent commercial online translation service based on a new open-source machine translation distributed architecture (MMT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Content technologies and information management: ICT for digital content, cultural and creative industries
Action type: Innovation actions
Countries involved: Italy,Italy,Netherlands,United Kingdom
Call: Cracking the language barrier (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 3695200.0
EU funding (EUR): 2994700.0
Participants: 4
Project status: CLOSED

The goal of MMT is to deliver a language independent commercial online translation service based on a new open-source machine translation distributed architecture. MMT does not require any initial training phase. Once fed with training data MMT will be ready to translate. MMT de-facto will merge translation memory and machine translation technology into one single product. Quality of translations will increase as soon as new training data are added. MMT manages context automatically so that it will not require building domain specific systems. MMT will provide best translation quality for any topic/domain by storing training segments together with context linking information. MMT enables scalability of data and users so that no more expensive ad-hoc hardware installations are needed. The MMT architecture will support high performance and linear scalability up to thousands of nodes. The same software will work to set-up a personal translation system or to create a web-based service on a cluster of commodity nodes able to handle terabytes of data and millions of users. MMT will create a data collection infrastructure that accelerates the process of filling the data gap between large IT companies and the MT industry. MMT will leverage the data crawled on the web by Common Crawl, TAUS, Translated’s MyMemory and Matecat data and facilities to set up a processing pipeline that will create unprecedented amounts of clean parallel and monolingual data to develop machine translation systems.

Keywords: machine translation,web translation,big data,data crawling
Mapping the Intraflagellar Transport - A High-resolution Study of Intraflagellar Transport Trains in Chlamydomonas Cells (TRAIN SPOTTING)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Cilia are highly conserved eukaryotic organelles that, with the exception of fungi and higher plants are present in nearly all types of organisms from protists to mammals. Through their motility, sensory, and signaling functions cilia play crucial roles in human physiology and development. Defects in cilia have profound impact on human health. Cilia assembly requires a dedicated protein shuttle, intraflagellar transport (IFT), a bidirectional motility of multi-megadalton protein arrays along ciliary microtubules. Although the overall mechanism of transport is generally described, complete high resolution structural description is necessary for the detailed understanding of this complex system. I propose the in-depth structural analysis of IFT features, train types, cargoes, interactions with the molecular motors in the cilia model organism Chlamydomonas. This approach will bring us both a molecular resolution of incorporated protein complexes and dynamic overview of their relations. The project objectives will be achieved by an elabrated chain of methods based on correlative microscopy, combining the specificity of nanobody labelling with the structure preservation and molecular resolution of cryo-electron tomography. We plan to develop two independent workflows for tracing the IFT features based on the most progressive cryo methods in the cooperation with the project partners. It is anticipated that an detailed ultrastructural 3D analysis of intraflagellar transport will provide new fundamental mechanistic insights into this very important biological process. We also expect an overlap to the whole structural biology field due to the methodical development, which will be universally applicable for another structural studies.

Keywords: intraflagellar transport,ift trains,tubuline,cryo electron tomography,corellative microscopy
OUITAXI (or WETAXI) a taxi on demand and taxi sharing service (OUITAXI)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

OUITAXI (or WETAXI) aims at developing a taxi on demand and a taxi sharing service. The specific objective is to foster the use of taxis by: - making the fare more convenient and competitive (share the ride and reduce the cost per single passenger) - making the service more transparent (fixed fares defined through quotes) Phase 1 of the SME instrument will allow for the realization of a feasibility study for the development and implementation of a taxi sharing service in the city of Turin and further expansion. The study will include a detailed business plan that takes into account market analysis, value proposition, customer validation, product validation, strategy and economics.

Keywords: sharing mobility,taxi sharing
Divergent Meanings: understanding the postmortem fate of human bodies found in Neolithic settlements from the Balkan area in light of interdisciplinary data (DivMeanBody)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This research proposal is designed as an exploration in the construction of the prehistoric body and identity, by studying the post-mortem fate of human remains discovered in Neolithic settlements in the Balkan area (between 7th-5th millennia BC). These settlements have yielded collections of disarticulated/fragmentary/scattered human remains. Traditionally such human remains have been either a focus of osteological studies, looking at them in a biological dimension, or subjected to cultural analysis. DivMeanBody aims at taking a multi-disciplinary comparative perspective, at the cross-road of archaeology and osteology, towards the re-interpretation of such deposits from a taphanomic perspective to answer the question of whether these are deliberate depositions or more complex, including non-cultural processes, might explain this fragmentation. The beginnings of settlements, agriculture and the Neolithic way of life are marked by such funerary practices, and studying them is integral to understanding past ways of life and cultures. Through its aims, DivMeanBody will help us better understand how these past people were performing and dealing with the dynamic processes of life and death in their communities and the relation of these practices to the formation of archaeological deposits. In the same time, it will surpass the divide present in contemporary research between a biological body (studied by osteology) and a cultural body (by archaeology). The results of DivMeanBody will bring an original contribution that can challenge contemporary distinctions between domestic-funerary space, whole bodies-fragmentary parts, the world of the living-the realm of the dead. It will also create links between categories of archaeological material which are otherwise interpreted separately and thus offer new insights into what being human meant in the past.

Keywords: body,funerary archaeology,osteology,taphonomy,human remains,neolithic,balkans,settlements