Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding microbe-induced stomach cancer – the key to a workable strategy for worldwide prevention (PreventStoCan)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-07-01
End date: 2022-06-30
Duration (months): 72.0
Total project cost (EUR): 1941531.0
EU funding (EUR): 1941531.0
Participants: 1
Project status: CLOSED

Stomach cancer is the 4th most common cancer and 2nd leading cause of cancer-related death worldwide. The aim of this proposal is to deepen the understanding of mechanisms involved in microbe-induced gastric carcinogenesis, which will facilitate risk stratification for identification of high-risk groups and may offer new opportunities for pharmacological and probiotic prevention. We hypothesize that novel H. pylori genotypic variation can predict carcinogenicity. The cancer-causing H. pylori strains may no longer be present at the time of cancer diagnosis, displaced by a changed microenvironment and invading microorganisms. We further hypothesize that the composition of invading microorganisms determines the risk of stomach cancer. To test these hypotheses, we will perform a case-control study nested within a historic cohort of patients with gastric biopsies taken decades ago. For cases who developed stomach cancer several years after index biopsy and their matched controls, paraffin-embedded blocks will be retrieved for metagenomic analysis of H. pylori and other microfloras, using our new method with laser capture micro-dissection, DNA amplification and sequencing. Interactions of host response and environmental exposures with the gastric microbiome will also be checked. To explore the molecular mechanism underlying the gastric carcinogenesis, we will further examine gastric epigenetic changes and mutation profiles by novel methods which require minute amount of starting material. Moreover, we will develop non-invasive tests for infections with carcinogenic strains of H. pylori and other microorganisms, which can easily be deployed in low-resource countries. This project will not only contribute significantly to reducing the worldwide burden of this dreaded malignancy, but also broaden our understanding of the mechanisms linking infection, inflammation and cancer development, and open a door for research using the vast resources of archived pathology materials.

Keywords: stomach cancer,primary prevention,helicobacter pylori,microbiome,metagenomics,genomics,epigenetics,microbe host environment interactions,carcinogenesis,tumour mutation,molecular epidemiology
The cardiovascular consequences of endurance exercise (CARDI-ACHE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-12-01
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Problem: Exercise training represents an attractive and low-cost strategy to improve cardiovascular health. Recent studies, however, report novel evidence that endurance exercise can lead to potentially detrimental cardiac maladaptations. First, acute exercise-induced elevations in cardiac troponin (cTn) levels have been found, which typically reflect myocardial (micro-)damage and are predictive of future cardiovascular events and mortality. Secondly, myocardial fibrosis has been reported in 12–50% of individuals engaged in lifelong exercise training, reflecting scarring of cardiac tissue that is typically found in patients with cardiovascular diseases (CVD). These cardiac maladaptations are highly unexpected and largely unexplained in apparently healthy individuals. CARDI-ACHE: Based on the latest scientific insights, the overall aim of this proposal is to elucidate the clinical importance of exercise-induced cTn elevations and myocardial fibrosis in endurance athletes. Better understanding of the clinical relevance of these adaptations is important to differentiate between the beneficial and the potentially harmful effects of exercise. Accordingly, I will study the following scientifically and clinically relevant questions: I. What is the prognostic value of exercise-induced cTn elevations? II. What are the functional consequences of myocardial fibrosis and are these mediated by lifelong physical activity? III. Do exercise-induced cTn elevations contribute to the development of myocardial fibrosis? Relevance for science & candidate. With this project, I will use the most technologically advanced approaches and tools to understand the clinical relevance of potential cardiac maladaptations to exercise training. The studies are performed in a world-renowned research group which allows me to expand my expertise in exercise cardiology using state-of-the-art facilities.

Keywords: troponin,myocardial fibrosis,cardiac structure,cardiac function,exercise,athletes,physical activity
The Informal Nocturnal City (INF_NIGHT): Towards a new generation of research and policy agenda about urban informality and nightlife in the 21st century South Europe (INF NIGHT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-09-27
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 2
Project status: SIGNED

Urban poor and marginalised communities have suffered the impact of austerity policies, structural re-adjustment and increased precariousness since the 2008 financial crash; a problematic situation aggravated by the COVID-19 pandemic (ILO, 2020). Irregular, low-income employment have become daily survival strategies for many ordinary people. In this sense, transnational un-regulated migrants, and more generally racialised bodies, are the most vulnerable actors suffering in Southern European cities from informality and the application of national migration laws, surveillance and securitisation measures and local policies based on 'zero tolerance' models. Interestingly, the night has become to many of them a space-time to escape or transgress surveillance: taking advantage of under-regulated local spaces, many (racialised) precarious actors - such as street informal vendors, sex workers and petty dealers - spend their nights avoiding police patrols in order to work, play, move or rest. However, the demonisation of this (Informal) Nocturnal City through moral panics reproduced in media and public discourse is used to justify spatial displacement of undesirable (precarious) actors from central areas in post-industrial Southern European cities and their exclusion from policy-making. The proposed training programme will enhance debates in both the academic and urban policy and planning literatures concerning the informal night, through a transnational, policy-oriented study undertaken in Lisbon, Madrid and Rome. Through a novel combination of conceptual frameworks based on three fundamental pillars (informality, nocturnal life and urban security), and articulating these three with debates on urban governance, I aim to address the ways in which informal practices conducted during night are imagined, negotiated and (re)produced and how these fundamentally affect urban change in post-industrial Southern European cities.

Keywords: urban,informality,security,night,southern europe,migration,work,trade unions,visual ethnography
Reusable launch vehicle for small payloads (ARION)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Spain
Call: Engaging SMEs in space research and development (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-02-01
End date: 2020-09-30
Duration (months): 32.0
Total project cost (EUR): 2792377.5
EU funding (EUR): 1954664.25
Participants: 1
Project status: CLOSED

Approximately 600 satellites have been launched in the last 6 years with an average annual growth of 40%. The decline in launches has been seen since 2014. Over 100 small satellites were impacted by the 2016 delays, due to the fact that there are no rockets designed for small payloads and cubesats, and only 6 large launchers around the world accept small payloads. An alternative is the International Space Station (ISS), which requires special safety qualification for each payload and have limited flight opportunities. Therefore, concentration on relatively few launch vehicles increases uncertainty in the launch schedule for small satellite operators and limits near-term growth. The opportunity to test the technologies in suborbital space is significant for the developers of space, biomedical and pharmaceutical technologies, enabling them to advance the technology maturity or achieve space demonstration and qualification/certification, which otherwise will take more time or even will be impossible. PLD proposes revolutionary reusable rockets, to be used as micro-launchers and suborbital launch vehicles. The development of the micro-launcher foresees the demonstration of a smaller scale reusable rocket for commercial suborbital flights, ARION, whose design will be completed and then flight qualified within this Ph2 project. We will provide the first commercial micro-launcher service in Europe and second world-wide, exclusively designed for small payloads and fully managed by our team. For the first time ever, small payloads will fly to Space as primary payload and at an affordable price. The key objectives of this project are to finalise the design of ARION suborbital vehicle, to develop a launch infrastructure, and to qualify the reusable launch vehicle in space, leading to commercialisation of the first commercial sRLV in Europe and mirco-launcher.

Keywords: launch vehicle,micro launcher,suborbital launch vehicle,sounding rocket,nanosatellite,reusable rocket
Training Network Sustainable Technologies (TRANSIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Germany,Malta,Netherlands,United Kingdom,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 2609581.68
EU funding (EUR): 2609581.6799999997
Participants: 7
Project status: SIGNED

Over the last few decades major efforts have been made to develop innovative food technologies that deliver safe, nutritious foods with high organoleptic qualities that meet consumer demands. Sustainable technologies such as Pulsed Electric Field, Ultrasound, Non-Thermal Plasma and High Hydrostatic Pressure offer consumer benefits like clean label food products and solutions to anti-microbial resistance. Nevertheless, their application is currently limited in the food industry. Some key technical blockers of wider application include the narrow range of product applications realized, variability in antimicrobial effects and engineering challenges related to upscaling. Additionally, consumer acceptance is currently low. TRANSIT brings together 13 participating organisations from 8 European countries to offer the necessary interdisciplinary and intersectoral training to the next generation of scientists to optimize and drive utility of these sustainable technologies in the food industry. Participants’ expertise at the interfaces of microbiology, process technology, cost benefit analyses, risk assessment and consumer sciences will provide comprehensive training to ten ESRs. Using a functional genomics approach, TRANSIT will identify the main microbial molecular targets in five model species that represent major food associated pathogens and spoilage organisms and will design effective antimicrobial impact strategies for the non-thermal technologies accordingly. In concert with renowned industrial partners, the product range for application will be extended and upscaling of the equipment will be realised. Importantly consumer acceptance studies will be used to support broader product application of the optimized technologies in the food industry. TRANSIT will nurture successful collaborative relationships between first-class universities, companies, governmental and research institutions, and contribute to the competitiveness and leadership of the food sector in Europe.

Keywords: sustainable food processing,food microbiology,process technology optimization,cost benefit analysis,consumer perception,risk assessment
Cosmology with voids and superclusters: combining theory, simulation and observation (COSMOVOID)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The aim of this cosmology proposal is to study the contents, history and evolution of our Universe, using the distribution of matter on large scales. I propose to study new methods to identify and catalogue rare voids and superclusters in the large-scale structure of the Universe and to study their statistical, morphological and dynamical properties. I will use these studies to propose new observables and new techniques of data analysis based on these structures, and to use this knowledge to test theories of gravitation, dark energy and the initial conditions of the early Universe. Interest in cosmic voids in particular has increased greatly in recent years, as they have been suggested as extremely competitive probes of cosmology, according to some estimates significantly out-performing other methods. Yet there remain unsolved theoretical difficulties in the modelling of voids and even a lack of consensus on how to identify them and how to relate theory and observation. Even less is currently known about superclusters. These are among the important issues I propose to address. My proposal consists in roughly equal parts of: analysis of the latest high-quality survey data which will available from the Sloan Digital Sky Survey (SDSS) and the Dark Energy Survey (DES); analysis of the state-of-the-art Jubilee ISW and weak lensing simulations run on the Juropa supercomputer in Germany; and theoretical work to combine insights from data and simulation to improve our understanding of cosmology. The proposed work is to be carried out in collaboration with leading experts in the respective fields from across the European Community, in particular in the United Kingdom, Spain and Germany.

Keywords: cosmology,large scale structure of the universe,voids
EXAscale Quantification of Uncertainties for Technology and Science Simulation (ExaQUte)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: High Performance Computing
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Switzerland,France,France,Czechia
Call: Transition to Exascale Computing (H2020-FETHPC-2017, 2017)
Start date: 2018-06-01
End date: 2021-11-30
Duration (months): 42.0
Total project cost (EUR): 3124255.0
EU funding (EUR): 3124255.0
Participants: 9
Project status: CLOSED

The ExaQUte project aims at constructing a framework to enable Uncertainty Quantification (UQ) and Optimization Under Uncertainties (OUU) in complex engineering problems using computational simulations on Exascale systems. The stochastic problem of quantifying uncertainties will be tackled by using a Multi Level MonteCarlo (MLMC) approach that allows a high number of stochastic variables. New theoretical developments will be carried out to enable its combination with adaptive mesh refinement, considering both, octree-based and anisotropic mesh adaptation. Gradient-based optimization techniques will be extended to consider uncertainties by developing methods to compute stochastic sensitivities, This requires new theoretical and computational developments. With a proper definition of risk measures and constraints, these methods allow high-performance robust designs, also maximizing the solution reliability. The description of complex geometries will be possible by employing embedded methods, which guarantee a high robustness in the mesh generation and adaptation steps, while allowing preserving the exact geometry representation. The efficient exploitation of Exascale system will be addressed by combining State-of-the-Art dynamic task-scheduling technologies with space-time accelerated solution methods, where parallelism is harvested both in space and time. The methods and tools developed in ExaQUte will be applicable to many fields of science and technology. The chosen application focuses on wind engineering, a field of notable industrial interest for which currently no reliable solution exists. This will include the quantification of uncertainties in the response of civil engineering structures to the wind action, and the shape optimization taking into account uncertainties related to wind loading, structural shape and material behavior. All developments in ExaQUte will be open-source and will follow a modular approach, thus maximizing future impact.

Keywords: uncertainties quantification,optimization under uncertainties,space time,embedded,optimization,parallel adaptive mesh refinement,parallel octree,task scheduling,exascale
New multi-active cardboard packaging solution to extend the shelf-life of fresh fruits and vegetables by 40%. (FRESHTRAY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-06-01
End date: 2020-01-31
Duration (months): 20.0
Total project cost (EUR): 838750.0
EU funding (EUR): 587125.0
Participants: 1
Project status: CLOSED

In the EU28, 5% of the fresh fruits and vegetables (FF&V) yearly traded never make it to the supermarket shelves due to spoilage. This means a waste of 3.9 Mt of food and the loss of 8,970 M€. FF&V spoilage is caused by the contamination of micro-organisms activity (bacteria and fungi) and the F&V’s release of ethylene gas. We have developed FreshTray a cost-effective solution to significantly diminish FF&V discards in Europe. FreshTray is a multi-active cardboard packaging to extend the shelf-life of fresh FF&V by +40%. It consists on the application of a patented multi-active coating – made of natural substances – over the inner surface of the cardboard. This coating has proved antimicrobial, antioxidant and ethylene scavenger functions over the F&V contained in the packaging. We have successfully tested the solution in tomato and pepper. Besides its effectiveness and the price, there are two key additional advantages of our solution against our competitors: (i) easy implementation by users and (ii) versatility of the solution that can be adapted to any FF&V company need. F&V companies will be willing to adopt our solution, since it (i) will provide them more flexibility and bargaining power, (ii) will increase their competitiveness against regular products, (iii) will increase their benefits and (iv) will loss on average 50% less of F&V along the supply chain. In our company SAECO – cardboard packaging manufacturers since 1974 – we enjoy a privilege location close to more than 600 target users (some of them are current customers), since we are based in the south-east of Spain, a region known as the “European’s orchard”. FreshTray will be first launched in Spain and in further stages of commercialization we will reach other EU28 countries. This project will give us the possibility to add value to our products and to open new markets. We will upgrade from selling cardboard, to market advanced multi-active packaging solutions to F&V industries.

Keywords: multi active packaging,nanotechnology,essential oils,cyclodextrins,food waste,cardboard,corrugated cardboard,shelf life,fresh fruits and vegetables
Focused Ion Beam fabrication of superconducting scanning Probes (FIBsuperProbes)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Spain,Switzerland,Switzerland
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-10-01
End date: 2025-03-31
Duration (months): 54.0
Total project cost (EUR): 2993411.25
EU funding (EUR): 2993411.25
Participants: 5
Project status: SIGNED

Our vision is to enable a new era in scanning probe microscopy (SPM), in which nanometer-scale sensing devices – specifically superconducting devices – can be directly patterned on-tip and used to reveal new types of contrast. To realize this vision, we will use focused ion beam (FIB) techniques to produce sensors with unprecedented size, functionality, and sensitivity directly on the tips of custom-designed cantilevers. The key to this undertaking will be the unique capability of FIB to mill, grow, or structurally modify materials – especially superconductors – at the nanometer-scale and on non-planar surfaces. Our FIB-fabricated probes will include on-tip nanometer-scale Josephson junctions (JJs) and superconducting quantum interference devices (SQUIDs) for mapping magnetic fields, magnetic susceptibility, electric currents, and dissipation. Crucially, the custom-built cantilevers, on which the sensors will be patterned, will enable nanometer-scale distance control, endowing our probes with exquisite spatial resolution and simultaneous topographic contrast. The resulting imaging techniques will significantly surpass state-of-the-art SPM and help us to unravel poorly understood condensed matter phenomena, which are impossible to address with today’s technology.

Keywords: focused ion beam,scanning probe microscopy,squid,josephson junctions,van der waals heterostructures,2d magnetic materials,magic angle twisted bilayer graphene