Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Investigation of Beta-Amyloid Peptide Effects On Mitochondria Protein Homeostasis: From Pathogenesis to Therapy of Alzheimer Disease (MITOABETA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-05-01
End date: 2014-04-30
Duration (months): 24.0
Total project cost (EUR): 167390.4
EU funding (EUR): 167390.4
Participants: 1
Project status: CLOSED

Beta-amyloid peptide, a component of senile plaques and generated by proteolytic cleavage of the amyloid precursor protein (APP), is a key factor in the pathogenesis of Alzheimer disease (AD). Beta-amyloid peptide has been shown to influence negatively some important mitochondrial activities such as reducing the efficiency of ATP-production via oxidative phosphorylation, enhancing mitochondrial ROS generation, and subsequently altering mitochondrial Ca2+ homeostasis. Based on these observations, it has been well established that mitochondrial dysfunctions and oxidative stress play an important role in the early pathology of Alzheimer disease. However, the molecular mechanisms linking beta-amyloid peptide to mitochondrial defects and to an increased oxidative stress leading to neurodegeneration in Alzheimer disease remain largely unknown. The main general goal of the proposed project is to assess the molecular impact of an increased accumulation of beta-amyloid peptide on mitochondrial protein homeostasis. The data collected from this project may provide crucial insights into AD etiology and pathogenesis. Specifically the following aspects will be determined: i) Effects on mitochondrial protein biogenesis: import and folding of nuclear encoded proteins, endogenous protein biosynthesis and complex assembly; ii) Identification of specific protein targets and the extent of protein post-translational modifications by increased levels of oxidative and nitrosative stress; iii) Adaptive response of mitochondrial protein quality control components establishing the potential of therapeutic intervention in the system. This project is expected not only to clarify the molecular mechanisms of beta-amyloid-induced mitochondrial dysfunctions in the pathogenesis of Alzheimer disease, but it will provide potential basis for the development of new AD therapies and for the identification of new candidates as biomarkers for early AD detection.

Keywords: neurochemistry,mitochondria,beta-amyloid,alzheimer disease,oxidative/nitrosative stress,redox proteomics,mitochondrial protein quality control,alzheimer disease therapy and biomarker
Origin and Early Evolution of Plant Symbionts (SYMBIONTS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-09-03
End date: 2014-09-02
Duration (months): 24.0
Total project cost (EUR): 209033.4
EU funding (EUR): 209033.4
Participants: 1
Project status: CLOSED

Fungi and fungi-like eukaryotes are commonly associated with plants where they adopt a variety of roles ranging from ones of mutual benefit (e.g., nutrient acquisition via mycorrhizae in roots) to others that are exploitative to varying degrees (e.g., parasites). These associations are of great evolutionary importance, but although they are known to be ancient direct evidence from the fossil record is scarce. My research has shown that there exists a large, novel and as yet largely untapped source of information on early fossil fungi and fungi-like eukaryotes. This takes the form of collections of petrified plants made during the 19th and 20th centuries. Petrifactions preserve the anatomy of fossil plants in exquisite detail, which was the original focus of their collection and study, but it is now recognised that they also contain the well-preserved remains of microscopic eukaryote symbionts. Much material exists in a prepared form that is suitable for analysis (i.e., petrographic thin sections). My project will explore and develop this resource. I will undertake the first large scale systematic survey of an historic slide collection of petrified plants to document their microscopic eukaryotes. This will be based on the large and comprehensive collections at The Natural History Museum, London. I will be trained in state of the art imaging methods and phylogenetic analysis to enable me to document the diversity of the symbionts and to determine their affinities to key living groups. My overarching goal is to reveal and to understand the significance of microorganism/plant associations in the early development of land ecosystems.

Keywords: environmental science,paleontology : symbionts,fungi,fungi-like eukaryote,fossil,plant,mycorrhizae,palaeozoic.
The aggregation of p53 in response to changes in the proteostasis network (P53-AGGR-CANCER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2011-IIF, 2011)
Start date: 2012-08-08
End date: 2014-08-07
Duration (months): 24.0
Total project cost (EUR): 235000.0
EU funding (EUR): 235000.0
Participants: 1
Project status: CLOSED

The concept of the proteostasis network (PN) represent a systems biology approach to protein deposition diseases (e.g. neurodegenerative diseases, amyloidoses, type II diabetes). The PN includes all the cellular components involved in the synthesis, folding, and degradation of proteins, as well as the regulatory mechanisms required for maintaining a functioning proteome despite cellular stress, mutations, or protein misfolding. When the misfolded protein load exceeds the capacity of the PN to maintain, protein aggregation can occur. Protein misfolding and subsequent aggregation is already thought to be the main cause of neuronal death in neurodegenerative diseases. Our study on the aggregation of p53, however, is the first report of protein aggregation leading directly to increased cell proliferation of the same cell in which the aggregation occurs by a gain of function mechanism. p53 is a potent tumor suppressor, and it is the most frequently mutated gene in human cancer (approximately half of the cases). We observed that mutant p53 not only strongly aggregated in tumor cells, - thereby already eliminating one copy of p53 – but that it also co-aggregated in a dominant negative way with wild type p53 and its paralogs, p63 and p73, sequestering these tumor suppressors that are pivotal to prevent tumorigenesis. The ability of the PN to cope with mutant or damaged biological material varies with the differentiation stage of cells, as well as deteriorates with cellular senescence. According to our hypothesis, the decline of the PN, particularly its decreasing ability to control aggregation-prone mutant p53 proteins, is one of the contributing factors to the steadily increasing incidence of cancer with age. We are proposing to study the aggregation of mutant p53 proteins in undifferentiated, differentiated, and senescent cells to test our hypothesis and gain information on the key factors keeping p53 aggregation, and tumorigenesis, at bay.

Keywords: cell biology,molecular biology
Research Networks for Educational Reform A ‘School-University Research Network’ Perspective on Linking Teacher Education, Knowledge and School Development (RESEARCH NETWORKS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2013-03-01
End date: 2016-02-29
Duration (months): 36.0
Total project cost (EUR): 283568.1
EU funding (EUR): 283568.1
Participants: 1
Project status: CLOSED

School-university research networks aim for closer integration of research-based knowledge and practice by means of teacher research, which can provide sustainable educational development in both schools and universities. Recently, scholars have suggested that master’s programs for in-service teachers may be a promising avenue in developing such research networks for educational reform. This worldwide innovative approach can reveal promising directions for linking teacher education, knowledge and school development, which may ultimately contribute to improving education and enhancing student achievement. As such, it contributes to the European Union goal of improving higher education and education in general (Europe 2020 – Flagship initiative Youth on the Move). Given the recent proliferation of a ‘school-university research network’ perspective on in-service teacher education there remains limited empirical work about this type of research networks. This study aims to address this pressing research gap and the need for finding new ways of improving educational systems. Two innovative and promising contexts in the U.S. and U.K will be explored. Theory and methods from the interdisciplinary field of social networks and the fields of teacher learning and education studies will be combined. An original combination of quantitative and qualitative methods will be used as well as longitudinal network modeling to examine networks and processes over time. The project aims to provide the fellow with training and career development support at two world class universities to become a mature and excellent scholar in the European Research Area (ERA). The outgoing (University of California,U.S.) and return host (University of Cambridge,U.K.) have robust infrastructures to manage/implement the project and mentors are renowned scholars in the field of educational networks. Outreach activities and an international advisory board will secure application of experiences/results in ERA

Keywords: educational reform,networks,in-service teacher education,teacher training,adult education,teacher research,school-university collaboration,mixed methods,longitudinal network modeling
Atmospheric Characterisation of Exoplanets (ACE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-09-15
End date: 2015-09-14
Duration (months): 24.0
Total project cost (EUR): 192622.2
EU funding (EUR): 192622.2
Participants: 1
Project status: CLOSED

This fellowship project aims at the development of Dr. David Ehrenreich's young career, focusing on the atmospheric characterisation of exoplanets. More than 500 planets have been detected around other stars during the past 15 years. It is now time to go beyond the exoplanet census and start determining the physical and chemical properties of these new worlds, understanding how they formed, assessing their ability to host and sustain life, and eventually, detecting signs of life elsewhere in the Universe. These fundamental questions can be addressed by observations of exoplanetary atmospheres, supported by theoretical modelling. The objectives of the project are milestones leading to the detection of life: (i) detecting new worlds suited for atmospheric characterisation and (ii) pushing atmospheric characterisation of exoplanets toward the lowest-mass exoplanets, including hot neptunes and super-earths. These objectives will also serve the preparation of the detection and atmospheric characterisation of habitable, Earth-like exoplanets. To achieve these objectives, the applicant will work at the University of Geneva Observatory (UniGE), the leading actor in exoplanet detection aiming at becoming a European centre of expertise in exoplanets with a strong involvement in atmospheric characterisation of exoplanets. The fellow will get involved in the on-going planet search projects within the Harps and SuperWasp consortia. He will use his expertise in the atmospheric characterization of exoplanets to study the properties of the exoplanets detected at UniGE with space, ground-based, and archival spectroscopic data. He will participate to the implementation of projects that will enable the detection of numerous characterisable Neptune- to Earth-mass exoplanets: the ground-based transit survey NGTS (2013), the European PLATO space mission (2018), and the project of a mini-satellite dedicated at detecting and characterising exoplanets (2016).

Keywords: astrophysics,exoplanets,transits,atmospheres,spectroscopy,photometry
Software Engineering Properties of Functionally Enabled Languages (SEFUNC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-05-01
End date: 2013-08-31
Duration (months): 16.0
Total project cost (EUR): 127783.6
EU funding (EUR): 127783.6
Participants: 1
Project status: CLOSED

A new trend in programming languages and system design is the use of constructs derived from the functional language field. Owning to a variety of inherent characteristics, functionally enabled languages are emerging as a competent alternative to object-orientation in environments requiring fast development turnover. Despite the apparent increase in their use, the software engineering properties, including the alleged advantages, of such languages are largely unexplored. With the proposed project, I aim to investigate whether the functional characteristics present in modern languages improve developer productivity and reduce code complexity, by designing tools and methods that will allow me to empirically assess existing applications. On the software complexity front, I propose the design of a new metric that unifies complexity estimation in functional and imperative environments. On the productivity front, I propose functional equivalents as a way to compare developer expressiveness between programming languages. In addition to the research targets, the project complements my long term objective to achieve research independence, by enabling my move to a different working environment and allowing me to receive training in career advancement fields, such as research leadership and teaching. The project has a target duration of 18 months and will be executed at TU Delft, with guidance provided by Prof. Arie van Deursen.

Keywords: software technology
Redox Ligands and Iron Complexes for Sustainable Catalysis (FESUSTCAT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-05-01
End date: 2014-04-30
Duration (months): 24.0
Total project cost (EUR): 201932.4
EU funding (EUR): 201932.4
Participants: 1
Project status: CLOSED

Transition metal complexes have a remarkable diversity of uses, with applications in fields varying from medicine to catalysis and materials science. The development of precious metal catalysis has dramatically altered the field of organometallic chemistry. The most well established and consequently most frequently used catalysts contain palladium, gold, iridium and rhodium. While these catalysts are frequently employed in organic synthesis, they suffer from the drawbacks of being some of the scarcest elements available on Earth and therefore also some of the most expensive. These realities have motivated scientists to search for more abundant and cheaper alternatives. In contrast to this reliance on precious metals, Nature is able to effectively harness the reactivity of Earth-abundant metals. Exploiting the reactivity of metals utilised in biological systems will allow the development of environmentally and biologically benign catalysts from metals such as iron. Accordingly this will revolutionise ways of constructing new carbon-carbon and carbon-heteroatom bonds, processes that are fundamental to synthetic organic chemistry. Reliable methods that exhibit good functional group tolerance are highly desirable and cycloisomerisation reactions, which construct carbocyclic and heterocyclic rings, are key to this work. This proposal will develop robust methodology utilising redox active iron-based complexes as catalysts that are both efficient and convenient, holding great importance in organic chemistry for the reliable construction of a diverse range of heterocycle motifs. Through this project novel iron-based catalysts will be developed that have the potential of improving the cost effectiveness of important synthetic processes. This in turn will impact positively on industries that rely on heterocyclic molecules (e.g. pharmaceuticals).

Keywords: physical sciences,homogeneous catalysis,organometallic chemistry,computational chemistry,iron,redox,catalysis,mechanism,cycloisomerisation,allene,heterocycles
Artificial intelligence, branching processes and coalescent – Searching the Information from a genetic Cornucopia (ARSINFORMATICA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-2011-IOF, 2011)
Start date: 2012-10-01
End date: 2014-09-30
Duration (months): 24.0
Total project cost (EUR): 206406.5
EU funding (EUR): 206406.5
Participants: 1
Project status: CLOSED

The objective of the multidisciplinary ArSInformatiCa project is to reinforce the international dimension of a research career of European computer scientist by training him in complementary skills in a world-class research centre, the George R. Brown School of Engineering at William M. Rice University in Houston, USA. The research will be carried out in two fields of information sciences: artificial intelligence (in particular machine learning) and distributed computer simulations applied to retrieval meaningful information from the whole-genome-scale variation data produced by high throughput genotyping technologies. In particular, the interest will be given to inherited predisposition to complex genetic diseases, including autoimmune diseases and cancers. An extremely large amount of data from the currently launched 1000 Genomes Project and Cancer Genome Project, requires a development of new advanced information technologies for understanding these data. This is an important challenge for information sciences, which motivates the goal of the ArSInformatiCa project. The progress in machine learning will not be limited to genetic applications. Rather, the methods developed, will be verified by application to human/cancer genetics with a potential to benefit wider and general context of data mining in very large and multidimensional data repositories. An example is the development of applicant’s rule-based method known as quasi-dominant rough set approach. While this method will be primarily tested in search for signatures of natural selection at molecular level in genes involved in human familial cancers, it is expected to become a general machine learning approach. Having a clear perspective of a long-term collaboration between Rice University and European research institutions, the ArSInformatiCa project will also contribute to the excellence of the European Research Area by a research inspired by the project results and performed after its completion.

Keywords: artificial intelligence,knowledge engineering,neural networks,applied informatics,biomathematics,machine learning,computer simulations,branching processes,human genetic variation
The Representation of the 'Exotic' Body in 19th-Century English Drama (REBED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-IEF, 2011)
Start date: 2012-10-01
End date: 2014-09-30
Duration (months): 24.0
Total project cost (EUR): 209033.4
EU funding (EUR): 209033.4
Participants: 1
Project status: CLOSED

REBED aims at a mapping of the presence of the 'exotic' body, that is, the cultural and physical body of the non-European Other, in 19th-century English drama, with specific attention to melodramas, farces, burlesques, pantomimes and extravaganzas. REBED aims in particular to investigate what practices and devices are employed to represent the ‘exotic’ body, to what extent the cultural, political and scientific discourses of the British Empire have influenced the dramatic representation of the ‘exotic’ body, and whether 19th-century drama was a major conveyor of racial and political values. In addressing these questions, the project ultimately aims to verify whether 19th-century English drama contributed to the forging of a politically-oriented perception of the non-European Other, and, if so, how. It will thus provide a model for further investigation on other areas, centuries and/or genres that may be of use for the framing of contemporary perceptions of non-European minorities in Europe. Although the general frame for the project is that of Drama and Literary Studies, REBED will also widely refer to disciplines such as Visual Studies, Anthropology and History of Science. In previous work, the researcher focused on 20th-century drama in English both from Great Britain and its colonies, as well as on the cultural and political (but not literary) background of 19th-century England. This project will allow the researcher to extend her expertise, as well as to develop a full interdisciplinary approach. The opportunity to work in a highly international context, to profit from specialized archives and the expertise of renowned experts, as well as to be able to develop complementary skills such as the management of dissemination and outreach events, will help the researcher strengthen her position within the academic community both in the medium and in the long term.

Keywords: english literature,theatre studies,cultural studies