Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Tracing epigenetic evolution of triple-negative breast cancer towards chemo-resistance (ChromTrace)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: SIGNED

The emergence of resistance to chemotherapy and targeted therapies is a major challenge for the treatment of cancer. While several genetic mechanisms driving resistance processes have been discovered, non-genetic mechanisms have also been shown to contribute to drug resistance. Yet, our restricted understanding of epigenetic evolution has so far limited our ability to modulate resistance using epigenetic modifiers. With ChromTrace, our goal is to reconstruct and define the contribution of epigenetic evolution to chemo-resistance in triple-negative breast tumors. In this aggressive sub-type of breast cancer, chemotherapy is the standard of care, but chemo-resistance remains the major unmet clinical need. We will explore the heterogeneity of H3K27me3chromatin states - key determinant of cell identity - in tumor cells, study how they are transmitted and determine whether they are associated to the resistance phenotype. Combining lineage tracing and targeted sequencing to our original single-cell chromatin profiling approach, we will reconstruct the dynamics of chromatin features over time in the context of genetic evolution. In parallel, using a live-cell microscopy reporter system, we will evaluate the association of recurrent chromatin features with the resistance phenotype and elucidate mechanisms of epigenetic tumor evolution. Our results on the heritability and plasticity of chromatin landscapes will have strong impact on our understanding of epigenetic evolution in cancer. Our long-term goal is to build on this integrated appreciation of molecular tumor evolution processes to propose novel therapeutic strategies to control resistance to chemotherapy. Finally, our approaches being applicable to any dynamic biological system, ChromTrace opens the perspective to study evolution of chromatin landscapes not only in other types of cancer and disease, but also during normal development.

Keywords: epigenetics,heritability,plasticity,breast cancer,chemotherapy,single cell chromatin immuno precipitation
Green Hydrogen Production and Plastic Recycling via Anion Exchange Membrane Reactors (PHOENIX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

Achieving climate neutrality by 2050 is currently acknowledged as one the overarching objectives of the EU strategy, where smart sector integration and a just transition to a circular economy are crucial drivers. In this respect, PHOENIX aims to develop and deliver a disruptive electrochemical reactor combining hydrogen production and plastic waste recycling. Hydrogen has manifold applications i.e., fuel, energy vector and chemical feedstock, and polymer synthesis is prevalent, 260 Mtons synthesised just in 2019 and no drastic reduction in near-term projections. Clearly, a suitable portfolio of novel and scalable technologies is urgently needed to process both commodities (hydrogen & plastics) in a sustainable way. Whence, ramping up the production of green hydrogen, i.e., renewables-derived, perfectly intertwines with the need to boost the whole volume of recycled plastic which currently amounts to only 15% of the total plastic in circulation. To this end, PHOENIX will produce an integrated power-to-molecules device by interfacing a fuel-producing/waste-recycling system to photovoltaic modules. The envisioned system will leverage an exquisite control in the assembly of modular Anion-Exchange Membrane (AEM) electrolysers, processing of nanostructured electrocatalysts and development of value-added chemical reactions to produce a scalable solar-to-chemical reactor. Finally, field validation and techno-economic assessments will identify and potentiate sector coupling along the entire energy and chemistry value chains. This project will be accomplished by an innovation-oriented small-sized enterprise, a world-class academic group and an experienced researcher, embedded in an inter-sectorial research landscape that brings lab innovation to fab delivery. Overall, the PHOENIX approach responds to key societal goals in energy conversion and environmental reparation: hydrogen production, waste valorisation and industrial innovation.
Methods in Research on Research (MIROR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Belgium,Croatia,France,Netherlands,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EJD) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-03-01
End date: 2020-02-29
Duration (months): 48.0
Total project cost (EUR): 3864090.24
EU funding (EUR): 3864090.24
Participants: 9
Project status: CLOSED

Our aim is to create, in Europe, an innovative and ambitious multidisciplinary intersectoral joint doctoral training programme, dedicated to Methods in Research on Research (MIROR) in the field of clinical research. “Research on Research”, is an emerging new scientific discipline that aims to reduce waste in research and increase research value. Waste in research represents tens of billions of Euros spent each year on studies that are redundant, flawed in their design, never published or poorly reported. The public is the main victim of this waste and reducing waste and increasing value of research represents a major societal challenge. Our proposal involving 15 early-stage researchers, aims to 1) prepare students for envisioning the future challenges in clinical research and find innovative solutions to face them, 2) train students to go well beyond the state-of-the-art in their research, 3) help students think differently, taking advantage of the multidisciplinary expertise and intercultural diversity of the network, 4) teach students how to move from research to action and convert knowledge and idea into a product, and 5) help students develop skills to match the public and private sector needs and create new professional opportunities. MIROR will bring together 7 world-class research teams in various disciplines (computer sciences, applied mathematics, biostatistics, bioinformatics, clinical epidemiology, psychology, social sciences and translational medicine) from 6 different European countries; 6 non-academic partners involved in diverse sectors, and 4 major academic partners. We will tackle several steps of a clinical research project (planning, conduct, reporting and the peer-review); various study designs (observational studies, randomised trials, systematic reviews); various study questions (therapeutic, diagnostic, and prognostic evaluation) using various methods (meta-epidemiologic studies, qualitative studies, experimental studies, simulations etc).

Keywords: research on research,meta research,clinical research,clinical trials,diagnostic test,peer review
Scalable multidimensionAl sitUation awaReness sOlution for protectiNg european ports (SAURON)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Protect and improve the resilience of critical infrastructures, supply chains and tranport modes
Action type: Innovation actions
Countries involved: Spain,Spain,Italy,Austria,Belgium,Greece,Slovenia,France,United Kingdom
Call: Prevention, detection, response and mitigation of the combination of physical and cyber threats to the critical infrastructure of Europe. (CIP-2016-2017-1, 2016)
Start date: 2017-05-01
End date: 2020-09-30
Duration (months): 41.0
Total project cost (EUR): 8491172.5
EU funding (EUR): 6926369.5
Participants: 15
Project status: CLOSED

Nowadays coordinated and every time more complex terrorist attacks are shocking the world. Due to the progressive rely of industrial sector and many critical infrastructures (CI) (e.g. EU ports) in ICT systems, the impact of a coordinated physical attack, a deliberate disruption of critical automation systems or even a combined scenario including both kind of attacks, could have disastrous consequences for the European Member States’ regions and social wellbeing in general. Taking into account this fact and this real threat on EU ports as one of the main CI in Europe, SAURON project proposes the holistic situation awareness concept as an integrated, scalable and yet installation-specific solution for protecting EU ports and its surroundings. This solution combines the more advanced physical SA features with the newest techniques in prevention, detection and mitigation of cyber-threats, including the synthetic cyber space understanding through the use of new visualization techniques (immersive interfaces, cyber 3D models and so on). In addition, a Hybrid Situation Awareness (HSA) application capable of determine the potential consequences of any threat will show the potential cascading effect of a detected threat in the two different domains (physical and cyber). On the other hand, through SAURON approach the public in the surroundings and the rescue/security teams will be able to be informed on any potential event/situation that could put in risk their integrity. Thus, SAURON proposes as main objective to ensure an adequate level of both physical and cyber protection for the EU ports and limiting, as far as possible, the detrimental effects for the society and citizens of a combined attack (physical & cyber) to an EU port. Reducing the vulnerabilities of EU ports, as one of the main European critical infrastructures and increasing their systemic resilience in the face of a physical, cyber or combined threat will be also part of the SAURON main objective.

Keywords: ports security,hybrid situation awareness,cyber situation awareness,physical situation awareness
3-D Super resolution Ultrasound Real time imaging of Erythrocytes (SURE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Denmark,Denmark,Denmark
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-03-01
End date: 2027-02-28
Duration (months): 84.0
Total project cost (EUR): 9980899.0
EU funding (EUR): 9980899.0
Participants: 3
Project status: SIGNED

The SURE project: "Super resolution Ultrasound Real time imaging of Erythrocytes" will develop and research a new super resolution ultrasound imaging method capable of resolving capillary flow in the human body. The approach tracks the motion of the individual red blood cells (erythrocytes) in a three-dimensional volume for a full visualization of anatomy, flow, and perfusion in a volume down to 13 cm at 20 volumes per second. The super resolution imaging is performed without using contrast agents and is thereby 2600 times faster than current methods. The method has an isotropic resolution of 50 micrometer in all directions, and the volumetric resolution is thereby 100-400 times better than current state-of-the-art 3-D ultrasound imaging. These highly ambitious goals are attained in a synergistic research effort combing four research groups. The scientific project includes breakthroughs in silicon row-column probes with 1 million elements, advanced synthetic aperture ultrafast coded imaging, deep learning for detecting and tracking of cells, pressure gradient estimation, and visualization and quantification of several hundreds of Gbytes volumetric data. The research finally leads to clinical trials conducted on rodents and humans for studying the changes in perfusion for diabetes and cancer. The SURE imaging approach can yield a paradigm shift in the scientific study, diagnoses, and treatment of cancer, diabetes, and vascular disease at the capillary level, as it enables the possibility of volumetric visualizing capillary perfusion in real-time at frame rates above 20 Hz without injection of contrast agents. Imaging is performed using ultrasound at normal diagnostic levels with no known adverse effects and can, thus, be used on a wide range of the population from newborns to the elderly for both diagnosis and repeated screening.

Keywords: ultrasound,super resolution imaging,row column arrays,deep learning,beamforming,diabetes,cancer,clinical trials
Platelet LYSAte based DERMal formulation for the treatment of skin ulcers (LYSADERM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The LYSADERM project aims at the fabrication of a medicinal cream containing Platelet Lysate (PL), that can be used for the topical therapy of skin ulcers. The applicant company Episkey is an innovative start-up founded in 2016 with the aim of introducing into the market novel therapeutic products obtained from human Platelet Lysate. Episkey holds the exclusive licenses of international patents covering the therapeutic administration of cord blood Platelet Lysate, and already developed an international network of cord blood banks aimed at the procurement of Cord Blood Platelet Lysate for pharmaceutical transformation into platelet derivatives and drugs. Within the broad scope of our company mission, the LYSADERM project aims at marketing a novel formulation of dermatological cream containing tissue regenerative factors present in human platelets. The LYSADERM dermatological cream will be therefore used for the treatment of skin ulcers, including serious disorders, such as diabetic foot ulcers, pressure ulcers and leg ulcers. LYSADERM aims to be the first pharmaceutical cream containing Platelet Lysate, and it is expected to improve healing of the ulcers in comparison to conventional treatments, at lower cost; therefore, it would become the standard procedure to treat diabetic foot ulcers, pressure ulcers and leg ulcers. The LYSADERM business project is expected to generate positive outcomes for the whole society, such as the increase of effectiveness in the treatment of skin ulcers both in hospitals and at the patient’s home. It is roughly estimated that once industrialized, LYSADERM can generate in just 5 years a total of over 10 M annual revenues, covering the 0.4% of the EU market share. Overall, the main objective of our phase I project is to achieve the technical definition of the LYSADERM product, to realize a complete exploitation plan, and to consolidate our business plan through a second-level FTO and the definition of the financial forecasts.

Keywords: pharmaceutical cream,platelet lysate,self application,skin ulcers,diabetic foot ulcers,pressure ulcers,leg ulcers
The Memory of Financial Crises: Financial Actors and Global Risk (MERCATOR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Italy
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-12-01
End date: 2025-11-30
Duration (months): 60.0
Total project cost (EUR): 2354381.0
EU funding (EUR): 2354381.0
Participants: 1
Project status: SIGNED

This project explores the extent to which the memory, or absence of memory, of previous financial crises can explain practices threatening the stability of the financial system. This will provide a major contribution to the understanding of the causes of financial crises, in particular the Global Financial Crisis, by helping to understand the behaviour of financial agents, marked by recurrent waves of over-confidence and excessive risk-taking, and why regulators fail to maintain financial stability. The project addresses four main questions: How are financial crises remembered? Has the memory of financial crises had an impact on the thinking and behaviour of financial actors? Has a ‘new’ financial elite emerged in the late twentieth and early twenty-first century? What has been the legacy of the Global Financial Crisis? Using the concept of cultural memory, the project analyses how the most severe financial shocks of the last hundred years (1929-33, 1982, 1997, and 2007-9) have been remembered. The memory of financial crises will be retraced by exploring five interrelated areas, resulting in: the first comprehensive analysis of senior bankers’ own views on financial crises; the first collective biography of the financial elite in the late 20th and early 21st century; a much clearer picture of the vision of financial crises prevailing in the financial world and its evolution in the second half of the 20th century; a new light on the place of financial crises in the teaching of economics and finance; and new perspectives into the history and memory of financial regulation. By focusing on financial actors and combining economic history and cultural history, the project will provide a missing link in our understating of the recurrence of financial crises, thus pushing the boundaries of knowledge, renewing our understanding of financial crises and contributing to the ongoing search for greater financial stability.

Keywords: financial crises,financial elites,financial regulation,economic history,financial,history,memory,europe,united states
Steering and radiation effects in oriented crystals and their applications implementation into Geant4 (TRILLION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,Korea, Republic of,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-02
End date: 2025-01-30
Duration (months): 36.0
Total project cost (EUR): 249465.36
EU funding (EUR): 249465.36
Participants: 3
Project status: SIGNED

Crystalline structure is a unique environment for strong-field QED effects involving both high-energy charged particles and photons. A small piece of crystal material could be used as an intense source of X- and gamma-ray radiation, a positron source, a beam manipulation instrument, a compact detector and a compact wake-field accelerator as well. Consequently, a crystal could be useful for a wide range of applications in accelerator physics, high-energy frontier physics, nuclear physics, cosmic-ray detectors, dark matter search and radiation therapy. The implementation of both physics of electromagnetic processes in oriented crystals and the design of specific applications of crystalline effects into Geant4 simulation toolkit as Extended Examples to bring them to a large scientific and industrial community and under a free Geant4 license is the main goal of the project. The implementation of the following innovative applications into Geant4 will be mainly focused on: 1. Crystalline deflector to extract a charged particle beam from an accelerator (electron synchrotron, hadron collider) to supply fixed-target experiments by an intense low-emittance beam. 2. Crystalline source of intense coherent hard X-ray and gamma radiation, crystalline undulator. 3. Crystal-based hybrid positron source for both linear and circular e+e- colliders (ILC, FCC-ee) as well as for muon colliders. The outgoing research phase of this MSCA-GF project at the Korea Institute of Science and Technology Information as well as training at Korea Advanced Institute of Science and Technology and University of Science and Technology and participation in high-tech Daedeok Innopolis exhibitions will bring the ER to a considerably higher level of competence. During the incoming phase at INFN Division of Ferrara supplemented by the secondments to DESY and IJClab the ER will finally reach his professional maturity and independence as well as will acquire a lot of new ideas to submit them as ERC proposals or to create high-tech startups and a lot of professional contacts to realize them.

Keywords: geant4,electromagnetic processes in oriented crystals,crystal channeling,x ray and gamma radiation source,positron source