Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Extending On-Demand wheel Drive to On-Road applications (E-ODD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-04-01
End date: 2019-07-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Today sectors like agriculture, forestry, transport, mining and construction require heavy duty vehicles that must outperform in highly demanding off-road conditions such as slope climbing and/or wet/slippery terrain. All while hauling or pulling large dead weight and facing obstacles bound to appear in un-paved roads. When performing these works, failure of the tractor to provide pulling force to the wheels leads to the convoy getting stuck. The solution is not a more powerful engine in the tractor head, the most efficient solution is to apply high torque at low speeds directly to the wheels. Black Bruin has developed the most efficient On-Demand wheel Drive solution, based on the integration of a unique wheel motor design. The result is an ODD system that can be integrated in trailers to power wheels, delivering traction force where is most needed, i.e. under the cargo. In this way, total power reduction of 30% and 20% fuel savings can be achieved, while increasing vehicle off-road / on-road use flexibility. Black Bruin is today’s third hydraulic LSHT motor supplier worldwide after giants like Bosch Rexroth and Poclain. We are a nearly 100-employee company, where 70% are employed in the manufacturing area and 30% in our offices. We count with a powerful portfolio of suppliers, research and academic institutions, consultants and engineering firms supporting our internal team. The new E-ODD system will allow us to move from a 15 M€ company to a 35 M€ company by dramatically extending the range of vehicle applications our product can be suited for.
New ways from photon to behaviour: Finding new phototransduction cascades in fan worms (PhoToBe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Vision is the sense for human beings. We can imagine how the world looks like for animals with visual systems like ours. But for animals with very different visual systems this differs, such as fan worms. Fan worms from different differ in their visual systems tremendously. Some have no visible eyes at all, maybe photosensitive cells not visible without technical help. Others have simple eyes consisting of a photoreceptor and a pigment cell. Others have complicated compound eyes, possibly mediating true vision. The different species form a progressing systems for studying eye evolution. These eyes evolved independently from vertebrate and insect eyes, because they are not in the head but on head appendages called fan. These eyes use also other phototransduction cascades than vertebrates or insects. However, what the exact components are, is unknown. My proposal seeks to answer that question.

Keywords: evolution of vision,phototransduction
SMARTHEP: Synergies between Machine leArning, Real Time analysis and Hybrid architectures for efficient Event Processing and decision making (SMARTHEP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Germany,Italy,Italy,Switzerland,Finland,Sweden,France,France,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-10-01
End date: 2025-09-30
Duration (months): 48.0
Total project cost (EUR): 3235231.5
EU funding (EUR): 3235231.5
Participants: 12
Project status: SIGNED

SMARTHEP is a consortium formed by academic and industrial partners on scientific, technological, and entrepreneurship aspects of real-time analysis. The focus of SMARTHEP is a central question in a data-rich environment: how to make the most of the available data to take decisions fast and efficiently, making the most of the available data. The main purpose of SMARTHEP is to train a new generation of inter-sector researchers and give them the tools to tackle this challenge, by processing large datasets in real- time, aided by Machine Learning and hybrid computing architectures. The results of SMARTHEP will benefit the HEP community in providing cutting edge technology and algorithms for the area of data selection (triggering) and particle detection, leading to precise measurement of the fundamental constituents of matter and enabling the discovery of new physics processes. The results of SMARTHEP include concrete commercial deliverables for industry in the fields of transport, finance and industrial decision-making processes. The training aspect of this work is crucial to SMARTHEP. The young investigators working within SMARTHEP will also be prepared as professionals in the upcoming and highly demanded area of Data Science. They will have the chance to gather work experiences and training in industry during their PhD degree and establish connections to companies, as well as acquire the skills that are necessary to a career in either industry or academia.

Keywords: real time analysis,heterogeneous computing architectures,trigger,machine learning
Effects of 3D topographies on mechanosensing in intestine epithelial architecture and dynamics (TOPOGRAPHYSENSING)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 134600.08
Participants: 1
Project status: CLOSED

Intestine epithelium consists of spatially segregated cells that organize into groups of various functions at different locations of the 3D curved epithelial monolayer. How geometric cues contribute to the maintenance of the sophisticated epithelial architecture and dynamics in 3D remains unknown until now. Recently, the Ladoux's laboratory has found that EpCAM-modulated cell contractility associated with the epithelial monolayer polarity, cytoskeletal arrangement, and cell-cell adhesion in 3D context. In contrast to 2D context, the EpCAM-defective tissue shows a loss of collective cellular spatial organization and forms a disordered multi-layered epithelium when exposed to substrates of 3D topographies. In addition, Ankyrin-G and α/β-spectrin network which participates in cortical tension modulation was identified as the main interacting partner with EpCAM in epithelial cells. These observations lead us to hypothesize that EpCAM allows the tissue to sense and conform to complex 3D topographies in an orderly manner. However, the molecular mechanisms and other related functions of EpCAM-mediated mechanotransduction remain unknown. As large scale mechanosensing has been shown to occur primarily through the actin cytoskeleton which permeates the tissue to form a network, we aim to understand the interactions between the EpCAM-mediated pathway and actin modulation and/or E-cadherin adhesion sites that may allow 3D topographical sensing. Our working hypothesis is that EpCAM forms an integral part of the cellular responses to topographic cues that has a more general role in controlling epithelial architecture and dynamics through the regulation of actomyosin networks, or vice versa. Here, we propose to scrutinize EpCAM-mediated mechanotransduction by generating a platform with precise control of geometric factors and microenvironmental cues using a range of multidisciplinary approaches including microfabrication, biophysics, and advanced molecular biology techniques.

Keywords: 3d topographic cues,epcam,actin cytoskeleton,mechanotransduction,intestinal epithelium,adherens junctions
Hyaluronan-rich matrices crosslinked with collagen-like peptides for 3D culture of ovarian cancer cells (MHAtriCell)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-15
End date: 2017-06-14
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

In recent years creation of artificial matrices from relatively simple biomaterials that can support tumour growth in 3D is becoming an increasingly popular platform for recreating the tumour microenvironment (TME) in vitro since 3D cell culture models can more realistically reflect the in vivo TME compared with 2D monolayer cultures. In this project, we will design and fabricate novel hydrogel matrices comprising of hyaluronan crosslinked with collagen-like triple helical peptide amphiphiles (PAs). The novel HA-PA matrix will contain built-in cell adhesion sequence, HA-binding motif and matrix metalloproteinase (MMP) cleavable sequences. We will characterise these 3D hydrogel matrices to support the encapsulation and culture of ovarian cancer cells. The MMP-assisted hydrogel degradation, migration and invasion of ovarian cancer will be studied on these models using advanced electron microscopic techniques and enzyme assays. In the final phase of our study we will characterise the inhibitory potency of a highly potent and selector inhibitor of MMP-2 and MMP-9 on this system. The findings from this study will have direct implications in understanding the mechanisms associated with ovarian cancer dissemination and the newly developed hydrogel matrix can find further use as a novel biomaterial in tissue engineering and as a 3D cell culture model in cancer drug discovery and delivery.

Keywords: hyaluronan,helical peptides,self assembly,matrix metalloproteinases,matrix degradation,3d models,cell culture,cell migration,tumor microenvironment,ovarian cancer
Training, Research and Raising of Public Awareness in Cell Biology and Pathology of Neuroglia (EU-GliaPhD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Italy,Italy,Germany,Italy,Germany,Norway,France,Netherlands,United Kingdom,United Kingdom,Denmark,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2016-12-01
End date: 2021-06-30
Duration (months): 55.0
Total project cost (EUR): 3924324.72
EU funding (EUR): 3924324.72
Participants: 17
Project status: CLOSED

The research in which the young scientists of the EU-GliaPhD consortium will be trained is centred on the role of neuron-glia interactions in brain function and pathology. Prompted by exciting discoveries of recent years, many academic research groups are currently focussing their research on the field of neuron-glia interactions for a better understanding of brain function. Also the private sector such as the pharmaceutical industry pays more and more attention to the role of neuroglia in various neuropathologies. These research activities create an increasing demand for outstanding young neuroscientists to join academia or industry. To address this need for neuroscientists with a strong knowledge in neuron-glia interactions, the EU-GliaPhD consortium of recognized European neuroscientists decided to initiate a training network in which young scientists, the EU-GliaPhD fellows will be educated in collaborative research projects to study neuron-glia interactions at the molecular, cellular and systems level in the healthy and the diseased brain. A strong emphasis will lie on epilepsy, a multi-faceted, chronic neurological disorder characterized by the frequent recurrence of seizures. The EU-GliaPhD consortium will focus on five important educational and training objectives: 1. Broad training in several current state-of-art technologies that are highly relevant for brain research 2. Teaching an in-depth understanding of molecular and cellular neurobiology and -pathology 3. Focused specialization in defined research projects 4. Training in dissemination of modern neuroscience research to expert and lay audiences 5. Education in soft skills such as article writing, oral presentations or research ethics By studying epilepsy, fundamental questions on the cellular and molecular aspects of neuron-glia interaction can be addressed. Novel insight delivered by EU-GliaPhD may serve as basis for the development of novel strategies in treating brain disorders.

Keywords: neuron glia interaction,transgenic mouse models,electrophysiology,in vivo laser scanning,microscopy,hippocampus,cortex,thalamus,mesial temporal lobe epilepsy,absence epilepsy
NOx-Mitigation Technology for Retrofitting Diesel Engines (NOXTEK)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: United Kingdom
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Alsitek Limited works on the commercialization of an innovative polymer-foam filter system for mitigating more than 85% of NOx emissions from diesel engines. The aim of the Phase 1 project is to confirm the technical feasibility and commercial potential of this ground-breaking retrofit technology to ensure a smooth transition towards a fossil-fuel-free economy in Europe. The current concerns about the health effects of vehicle emissions and the scandal around manipulated diesel engine emissions in passenger cars shows there is a need for disruptive and timely solutions. The Alsitek NOXTEK solution is a retrofit technology that goes beyond the current state of the art in terms of NOx mitigation (over 85%), with the capability to absorb large amounts of NOx over long time and excellent regeneration capabilities. NOXTEK meets several end-user needs in the diesel passenger cars market, including (i) an efficient NOx-mitigation solution to ensure compliance with the tightening environmental regulations (ii) the need for an ergonomic retrofit solution not affecting the warranties of the car’s subsystems and components (iii) a solution that can be applied in a de-centralized manner by technically adept end-users or at service points. The product is expected to be 78% more cost-effective than available retrofit solutions. Alsitek aims to target the diesel passenger car aftersales market first (to be confirmed in Phase 1). Adjacent markets to be targeted include diesel engine applications in low and heavy-duty vehicles, marine vessels and peaking power plants. NOXTEK is expected to save 6.2 tons of NOx emissions annually from the fifth year after market entry, which is an equivalent of 1847,6 tons of CO2. The Phase 1 work will focus on confirming the priority market for commercialization, conducting a feasibility for SMEi Phase 2 scale-up and demonstration, as well as work on strengthening Alsitek’s patent position and scouting on external manufacturing capabilities.

Keywords: polymer materials,diesel engines
GlucoBeam: A portable device for pain-free glucose self-monitoring in diabetic patients (GlucoBeam)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Denmark
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Diabetes mellitus (DM) is one of the largest health challenges currently faced by modern society, affecting 382 million people in the world. DM cannot be cured, but via well-controlled therapy, a high quality of life with diabetes can be obtained, with a minimum of short- and long-term complications. The key to a successful diabetes therapy is a well-controlled blood glucose level, which is obtained by carefully balancing insulin intake, diet, and exercise and with Self-Monitoring of Blood Glucose (SMBG) as a cornerstone. Conventional SMBG is an invasive test requiring the patient to prick his/her finger with a lancet to extract a blood droplet onto a disposable strip for electrochemical analysis of the glucose concentration. Repeating this uncomfortable and painful task 4-8 times per day leads to severe loss in life quality, often resulting in poor compliance leading to costly complications. RSP’s proprietary non-invasive SMBG technology relies on the capabilities of Raman spectroscopy for directly detecting individual substances, refined by a unique critical depth optical scanning to collect glucose signals from the right tissue depth range, thus avoiding sources of errors during the measurement. Our GlucoBeam device will enable DM patients to test their glucose levels in around 30s and as often as desired – at no added cost or pain – thereby empowering them to better manage their treatment and minimizing the risk for acute complications. GlucoBeam’s successful commercialization will position RSP to secure an aggregated turnover of approx. €253 million over the 5 years post-project period. Furthermore, it has the potential to reach double digit billion savings for EU’s healthcare systems and will ultimately lead to significantly improved life quality for the large population of diabetic patients. Moreover, GlucoBeam’s commercialization will allow RSP to set a market foothold in order to leverage its medium term innovation strategy.

Keywords: diabetes mellitus,self monitoring of blood glucose,non invasive testing,raman spectroscopy
Deconstructing the past: Modelling the locomotion of Miocene hominoids through computational techniques (DeMol)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-01
End date: 2022-02-28
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The challenge of better knowing the complex relationship between bone's morphology and function has yielded tens of articles since the beginning of the last century and is essential for making positional behavioural inferences on fossil taxa. Despite its relevance, the form-function relationship is still poorly understood. Based on this premise, this project focuses on deciphering the functional loading environment and its influence on skeletal design in the hindlimb of living primates and shedding light on the locomotor evolution of fossil apes and early hominins. The fossil apes included in this project constitute key taxa for understanding the positional behaviour evolution within the Hominoidea (the apes and humans clade), which has important implications for a better knowledge of the evolutionary pathway that led to the specialized locomotor types of extant apes and humans (specialized antipronograde behaviours such as below-branch suspension and human terrestrial bipedalism). To accomplish the aims, this project will rely on diverse, multidisciplinary and innovative techniques, including biomechanical and engineering approaches (e.g., multibody dynamics analysis, computer optimization, machine learning and data science), phylogenetic comparative methods, and collection of experimental data (e.g., recording of live primates kinematics). This project also involves an important component of training for the applicant and several short stays to gain a diversified and unique set of skills and knowledge on the field of paleoprimatology and evolutionary biology. Hence, this project will extend our knowledge on the bone's form-function relationship, as well as the origin, tempo and mode of the hominoids positional behaviour evolution, including key long-lasting questions related to the origins of human bipedalism.

Keywords: miocene hominoids,primate positional behaviour evolution,form function relationship,hindlimb,computational biomechanics,virtual palaeontology,machine learning,data science
Mechanisms of functionalized nanomaterials binding to microbes in gut (NanoBindMicro)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2022-01-01
End date: 2023-12-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Antibiotic-resistant microbes have become a serious health problem world-wide. Development of new antibiotics has been focused on killing pathogens. However, these antibiotics also kill other components of microbiome resulting in immune dysregulation. It is crucial to develop new strategies which can remove pathogens without damaging the homeostasis of the microbiome. Nanotechnology is one of the key enabling technologies identified in the European Union (EU) 2020 Strategy that may be promising in dealing with antibiotic-resistant microbe. My recent study showed that microbes' binding to nanomaterials (NMs) was dependent on NMs' characteristics. This finding inspired me to consider whether I can find functionalized NMs to recognize and remove specific pathogens from 100 trillion microbes in gut and pose no harm to the other microbes. The idea is novel and does not follow the conventional use of NMs killing microbes directly, but I believe this is possible because microbes have very different cell surfaces. This would enable the design of NMs that bind certain microbes but not others. I hypothesize that specific surface molecules of pathogens can be acted as the multiple targeted ligands for functionalized NMs to outcompete the binding sites of pathogens on the epithelium. To verify the hypothesis, I plan to use multiple ligand coated NMs, a new concept of personalized protein corona, and in vitro and in vivo gut microbiome models to study the mechanisms of functionalized nanomaterials binding to microbes in gut. My research experiences on nano-bio interactions combined with my host and collaborators’ expertise in nano-therapy (France), nano-protein corona (Germany) and nano-characterization (Denmark) will allow me to successfully execute this challenging program. The proposed study will result in a new strategy for using NMs to fight multi-resistant microbes without antibiotics.

Keywords: nanomedicine,antibiotic resistant microbes,nano protein corona,gut microbiome