Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Prediction of Children's Math Learning Disability Using Longitudinal Brain Data and Machine Learning (MathDevBML)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-05-12
End date: 2024-05-11
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

Mathematics is the fundamental basis of modern science and technology. However, individuals differ in mathematical ability, and 5%–7% of the population suffers from a math learning disability (MLD). To provide appropriate support for children with MLD, detecting MLD before entering the formal education system is essential. Previous studies have identified some of the neural correlates of MLD; however, computational approaches to predict MLD have been limited. Also, most studies recruited children who were enrolled in elementary school, which is problematic because negative math experience may worsen the difficulties. This research project aims to address these gaps. By combining brain data of preschoolers with state-of-the-art machine learning techniques, I will construct a computational model aiming at predicting MLD before children enter elementary school. The host laboratory of Dr. Jérôme Prado is currently conducting magnetic resonance imaging (MRI) experiments in 5-year-old preschoolers. Participants are presented with visual stimuli consisting of dot patterns, and their brain activity is measured using functional MRI. I will repeat the same MRI task two years later (when children are 7). The math skills of participants will be measured at the age of 7. Multiple algorithms (model-based and model-free approaches) will be applied to the brain data at the age of 5 to predict the occurrence of MLD at the age of 7. Computational models will be applied to other cognitive abilities (language, reasoning), and the influence on atypical math development will be examined. I will benefit from the strong administrative support and advanced neuroimaging resources at the Lyon Neuroscience Research Center, where I will receive training in technical and leadership skills. This research project is an excellent opportunity for me and the host to contribute to the growth of an innovative research field combining developmental neuroscience and machine learning techniques.

Keywords: arithmetic,development,machine learning,fmri
Long non-coding RNAs that regulate glial cell function in the diseased heart (GLIA-LNC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-02-28
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: SIGNED

Despite progress in acute treatment, heart disease remains the leading cause of death worldwide. Current treatments fail to prevent cellular disease processes or to promote tissue recovery after cardiac events. Since cardiac disease is accompanied by dramatic changes in neuronal integrity, understanding of the factors that regulate cardiac neuronal function and remodelling could facilitate development of novel therapies for heart disease. Long non-coding RNAs (lncRNAs) represent attractive therapeutic targets due to their highly cell type specific expression and function. Several lncRNAs were indeed shown to be causally involved in heart disease, but the vast majority of cardiac lncRNAs still await characterization. The heart is densely innervated by nerve fibres which regulate cardiac function on a beat-to-beat basis. In turn, glial cells (GCs), which cover almost all neuronal cell surfaces, locally regulate neuronal function and remodelling. While neuronal function and remodelling play a key role in heart disease, little is known about the role of cardiac GCs and their lncRNAs. My preliminary data suggest that cardiac GCs express many cell type specific lncRNAs that are deregulated in diseased conditions. To identify cardiac GC lncRNAs with therapeutic potential, I will 1) characterize cardiac GC populations that mediate neuronal remodelling in the heart, 2) identify conserved lncRNAs that determine cardiac GC identity and function, and 3) characterize their interaction partners and their ability to regulate key GC functions. These objectives will be addressed using cutting-edge techniques, including single cell sequencing and multiplexed CRISPR interference, during a fellowship at the research group of Prof. Engelhardt in Munich. To do so, I will receive extensive interdisciplinary training and benefit from world-class research infrastructure. Finally, proactive dissemination and communication will ensure that this fellowship benefits society as a whole.

Keywords: lncrna,glial cells,cardiovascular biology,heart disease,cardiac innervation,myocardial infarction
Modelling stability of organic phosphorescent light-emitting diodes (MOSTOPHOS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Cross-cutting and enabling materials technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Germany,Germany,Germany,Germany,Germany,Switzerland,Netherlands
Call: Widening materials models (H2020-NMP-2014-two-stage, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 3861111.75
EU funding (EUR): 3669436.75
Participants: 12
Project status: CLOSED

The lifetime, reliability, and efficiency of organic light emitting diodes (OLED) are critical factors precluding a number of novel devices from entering the market. Yet, these stability issues of OLEDs are poorly understood due to their notorious complexity, since multiple degradation and failure channels are possible at different length- and timescales. Current experimental and theoretical models of OLED stability are, to a large extent, empirical. They do not include information about the molecular and meso-scales, which prevents their integration into the workflow of the industrial R&D compound design. It is the idea of this project to integrate various levels of theoretical materials characterization into a single software package, to streamline the research workflows in order for the calculations to be truly usable by materials engineers, complementary to experimental measurements. Towards this goal, this project brings together the academic and industrial expertise of the leading experimental and theoretical groups in the field of organic semiconductors.

Keywords: stability,efficiency,phosphorescent organic light emitting diode,simulations,modelling
Dissecting the molecular mechanisms underlying YAP activation in intestinal tissue repair (InterYAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: SIGNED

Inflammatory bowel diseases (IBDs), such as ulcerative colitis and Crohn’s disease, are chronic and debilitating pathologies of the intestines that affect 2.5-3.0 million patients in Europe and impose an economic burden of approximately €5.0bn/year on European healthcare systems. Currently, no curative therapies are available and standard of care is limited to palliative anti-inflammatory treatments that fail to promote healing of the intestinal lining. Enhancing epithelial regeneration is likely to accelerate functional recovery and reduce exposure to luminal microbes, thereby avoiding further inflammation and, ultimately, chronic damage. However, the cellular and molecular mechanisms underlying regeneration of intestinal epithelium are not yet fully understood, and thus opportunities for pharmacological modulation remain scarce. Recently, the mechanoresponsive transcription factor YAP has been identified as a key mediator of epithelial repair in experimental IBD models. Yet, the molecular details of its function remain elusive. Here, I propose to carry out a proteomic study to dissect the mechanisms by which YAP is activated and exerts its functions in intestinal tissue repair. I will leverage the intestinal stem cell organoid technology and my expertise in CRISPR/Cas9 genome editing to: i) perform a detailed characterisation of YAP post-translational modifications and interacting protein partners using unbiased proteomic approaches; and ii) define the function of identified partners using novel in vitro and animal models of intestinal tissue repair. I envisage the study will provide a clear map of signalling pathways and molecular networks underlying YAP function and uncover potential druggable targets for pharmacological enhancement of intestinal tissue repair. From a professional perspective, execution of the project will equip me a valuable set of technical and transferable skills and ultimately facilitate my transition into a group leader position.

Keywords: inflammatory bowel disease,intestinal stem cells,organoids,crispr,cas9
Novel 2D quantum device concepts enabled by sub-nanometre precision nanofabrication (NanoFab2D)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Hungary
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-07-01
End date: 2021-06-30
Duration (months): 60.0
Total project cost (EUR): 1496500.0
EU funding (EUR): 1496500.0
Participants: 1
Project status: CLOSED

IIn today’s electronics, the information storage and processing are performed by independent technologies. The information-processing is based on semiconductor (silicon) devices, while non-volatile data storage relies on ferromagnetic metals. Integrating these tasks on a single chip and within the same material technology would enable disruptively new device concepts opening the way towards ultra-high speed electronic circuits. Due to the unique versatility of its electronic and magnetic properties, graphene has a strong potential as a platform for the implementation of such devices. By engineering their structure at the atomic level, graphene nanostructures of metallic, semiconducting, as well as magnetic properties can be realized. Here we propose that the unmatched precision and full edge orientation control of our STM-based nanofabrication technique enables the reliable implementation of such graphene nanostructures, as well as their complex, functional networks. In particular, we propose to experimentally demonstrate the feasibility of (1) semiconductor graphene nanostructures based on the quantum confinement effect, (2) spin-based devices from graphene nanostructures with magnetic edges, as well as (3) novel operation principles based on the interplay of the electronic and spin-degrees of freedom. We propose to demonstrate the electrical control of magnetism in graphene nanostructures, as well as a novel switching mechanism for graphene field effect transistors induced by the transition between two magnetic edge configurations. Exploiting such novel operation mechanisms in graphene nanostructure engineered at the atomic scale is expected to lay the foundations of disruptively new device concepts combining electronic and spin-based mechanisms that can overcome some of the fundamental limitations of today’s electronics.

Keywords: graphene,2d materials,nanofabrication,scanning tunneling microscopy
photonic system for Adaptable muLtiple-analyte monitoring of fOod-quality (h-ALO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Italy,Germany,Italy,Italy,Italy,Sweden,Poland,Netherlands,Netherlands
Call: Advancing photonics technologies and application driven photonics components and the innovation ecosystem (H2020-ICT-2020-2, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 4239432.0
EU funding (EUR): 4239432.0
Participants: 11
Project status: SIGNED

h-ALO aims to develop and demonstrate in real-setting a new photonic-based sensor which will allow local food producers and retailers to control food quality and safety, therefore increasing competitiveness in the whole food production value chain. The sensor will provide: • Unprecedented high sensitivity, low limit-of-detection and large dynamic range compared to previously developed portable systems through the combination of an analyte pre-concentration and a multi-modal detection scheme; • Miniaturization and integration of optoelectronic and plasmonic components allowing portability in optical detection; • Multiplex-analyte recognition, allowing the unprecedented detection of both microbiological and chemical contaminants such as pesticides/antiparasitic, heavy metals, micro-organisms; • Easy and fast sample preparation protocols which are adaptable for a wide range of food samples; • Measurement automation and fast response, making the sensor reliable for on-site use by farmers, retailers and non-expert operators; • Mobile-phone connectivity and cloud-based data management allowing a distributed, anonymous food monitoring along the farm-to-fork chain. The innovative technologies at the basis of the h-ALO sensor are: i) highly integrated organic/hybrid photonic components as light-source and photodetector; ii) nanoplasmonic biofunctionalized surface assessing innovative multimodal optical transduction; iii) innovative aptamer- and immunoassay-based bio-recognition elements for multiplexing; iv) a smart microsieve membrane for analyte pre-concentration. The h-ALO prototype will be validated in lab by quantitative comparison with benchmark commercially available methods and demonstrated on-site in small selected agri-food chains such as aquaponics, craft beer, raw milk and organic honey, and introduced into an HACCP manual.

Keywords: nanoplasmonics,microfluidics,system integration,miniaturization,optical,biosensor,bio recognition,membrane,data management,on site demonstration,food chains,portability
A Trans-AtLantic Assessment and deep-water ecosystem-based Spatial management plan for Europe (ATLAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Ireland,Spain,Spain,Norway,Belgium,France,United States,Netherlands,Netherlands,Denmark,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal,United Kingdom,United Kingdom,United Kingdom
Call: Improving the preservation and sustainable exploitation of Atlantic marine ecosystems (H2020-BG-2015-2, 2015)
Start date: 2016-05-01
End date: 2020-10-31
Duration (months): 54.0
Total project cost (EUR): 9167816.86
EU funding (EUR): 9100316.86
Participants: 30
Project status: CLOSED

ATLAS creates a dynamic new partnership between multinational industries, SMEs, governments and academia to assess the Atlantic’s deep-sea ecosystems and Marine Genetic Resources to create the integrated and adaptive planning products needed for sustainable Blue Growth. ATLAS will gather diverse new information on sensitive Atlantic ecosystems (incl. VMEs and EBSAs) to produce a step-change in our understanding of their connectivity, functioning and responses to future changes in human use and ocean climate. This is possible because ATLAS takes innovative approaches to its work and interweaves its objectives by placing business, policy and socioeconomic development at the forefront with science. ATLAS not only uses trans-Atlantic oceanographic arrays to understand and predict future change in living marine resources, but enhances their capacity with new sensors to make measurements directly relevant to ecosystem function. The ATLAS team has the track record needed to meet the project’s ambitions and has already developed a programme of 25 deep-sea cruises, with more pending final decision. These cruises will study a network of 12 Case Studies spanning the Atlantic including sponge, cold-water coral, seamount and mid-ocean ridge ecosystems. The team has an unprecedented track record in policy development at national, European and international levels. An annual ATLAS Science-Policy Panel in Brussels will take the latest results and Blue Growth opportunities identified from the project directly to policy makers. Finally, ATLAS has a strong trans-Atlantic partnership in Canada and the USA where both government and academic partners will interact closely with ATLAS through shared cruises, staff secondments, scientific collaboration and work to inform Atlantic policy development. ATLAS has been created and designed with our N American partners to foster trans-Atlantic collaboration and the wider objectives of the Galway Statement on Atlantic Ocean Cooperation.

Keywords: ecosystem function,biodiversity,fisheries,biogeography,connectivity,socioeconomics,ecosystems goods and services,maritime spatial planning,environmental assessment,policy
Optimum, sustainable solution for seed drying and conservation (DryCoolerSeeds)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Italy
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The seed market will grow at a CAGR of 10.57% during the period 2014-2019 and is expected to increase to $24 billion from its current $14.52 billion value. Europe, with 3 of its countries (France, Germany and The Netherlands) as three of the top four seed exporters in the world includes nearly 7,200 seed companies and more than 50,000 employees. Production of high quality seeds can increase crop yield by 15-20%. Seed moisture content needs to be controlled to ensure high germination rates, thus high quality seeds. An optimum drying process with control of air’s relative humidity and temperature is needed to ensure harvested seed is at safe moisture content before storage or other purposes. Existing drying and cooling methods for seeds lack of control of these parameters, are not energy efficient and require high investment from farmers. Moreover, seed drying is one of the most energy consuming processes on farms, consuming as much energy as all field works together. With an efficient seed drying process, savings for farmers could be more than 50%. DryCoolerSeeds is able to dry and cool the seeds in a continuous monitored process with adaptation to climate variations, saving energy (99% of energy saved), time (2.5 less time needed than traditional dryers), ensuring the correct moisture content and temperature of seeds, resulting therefore in high quality seeds. Marcold’s technology is a step further in automation, simplification and costs savings (>60% compared to mix flow drying) being able to incorporate two different functions (drying and cooling) in a single machine surpassing the competition in the current market. The aim of the project is to build and demonstrate in real end user’s facilities our DryCoolerSeeds prototype adjusting the working parameters for effective conservation of seeds while ensuring a successful commercialization of the technology in Europe and Latin America that will drive Marcold into an exponential growth.

Keywords: seeds,dryer,energy saving,moisture,relative humidity,temperature
Innovative solutions to scale-up urban green surfaces across Europe (ScalinGreen)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: France
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-2-2014, 2014)
Start date: 2015-07-01
End date: 2017-08-31
Duration (months): 26.0
Total project cost (EUR): 1057472.5
EU funding (EUR): 733231.0
Participants: 1
Project status: CLOSED

The ambition of this programme is to enable the widespread adoption of ground-breaking solutions to bring back nature in cities. Natural Grass offers disruptive solutions for urban greening: 1. AirFibr, the sports field application for football and rugby pitches, golf courses and horse-riding grounds 2. CityNest, the green building solution for green walls and green buildings 3. GreenMove, the future of urban infrastructure : green parking slots, green tramway track beds, green highway sound walls This programme aims at removing an important lock for Natural Grass: the mastery of its production process in orer to overcome the following limitations: - Flexibility: It only works with a very precise set of components - Control: Designed to produce the AirFibr substrate, the current line does not allow to vary the cork/sand/fibres ratio over all the range necessary to produce the substrate for CityNest and GreenMove, hence the substrate has to be manually enriched in cork - Reproducibility: a minor change in the process parameters or in the components characteristics can cause the process to fail To achieve these ambitious objectives, we propose an innovation programme structured in three steps: I. A study of the current process to formalize and generalize Natural Grass technical know-how II. The development of a set of innovative tools necessary for multiple substrate fabrication tests III. The completion of the final objectives: the development of a fully functional prototype line and of a wider range of appropriate substrate constituents.

Keywords: green roofs,green wall,urban greening,substrate,mixing,fibers