Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Disruptive Innovative Cooperative Entrepreneurial (DICE) education, training and skills development programme rolling out the next generation of Agri Biorefinery and Valorisation Bioeconomy leaders (AgRefine)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria,Ireland,Ireland,Belgium,Greece,Netherlands,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-10-01
End date: 2024-03-31
Duration (months): 54.0
Total project cost (EUR): 4038684.84
EU funding (EUR): 4038684.84
Participants: 8
Project status: SIGNED

This AgRefine European Training Network (ETN) will provide Early Stage Researchers (ESRs) with the necessary skills and knowledge to position Europe as the global leader in developing an agri-bioeconomy industry based on advanced biorefinery technologies. AgRefine disrupts the mechanism by which biomass is currently being used by cooperatively integrating innovative stand-alone technologies so that the highest value, socio economically beneficial products per input substrates, can be achieved. An integrated training programme will facilitate the amelioration of Europe’s agri-sector competitiveness and environmental sustainability challenges by creating new and optimising current agri-resource and agri-waste valorisation pathways. The ETN will consist of 15 highly interdisciplinary and inter-sectoral PhD projects, each specialising in specific aspects of the bioeconomy, and provide training in a number of cross-cutting multi-disciplinary and highly interdisciplinary advanced technical subject areas including chemical and process engineering, biological science, life cycle assessment, and economics. The network will combine assessment of legislation and policy as it applies to the bioeconomy, with industry-led innovation of AgRefine technology, and market-led experience of sustainable value chain creation. The ESRs will receive training on adopted RRI principles, project management, communication, presentation and media skills. The network will provide ESRs with access to partners with key-expertise in the bioeconomy, gaining a range of relevant transferable skills and expertise in environmental, economic and social aspects of AgRefine. AgRefine will build on successful partnerships from the H2020 AgroCycle project and will leverage the capabilities of the AgroCycle team as well as bring new partnerships into this ETN to provide key researcher training opportunities that the bioeconomy needs in order to be a successful “Bio-green Revolution” for Europe.

Keywords: bioeconomy,biorefinery
Planetary systems around white dwarfs (WDPlanets)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: United Kingdom
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2535290.0
EU funding (EUR): 2535290.0
Participants: 1
Project status: SIGNED

In the 25 years since the discovery of 51 Peg b, we went from not knowing if the Solar system is a fluke of Nature to realising that it is totally normal for stars to have planets. The common fate of practically all planet hosts is that they will eventually evolve into white dwarfs, the Earth-sized embers that are the evolutionary end-points of most stars. Many of the known planets will survive the post main-sequence evolution of their host stars - in the solar system, this includes Mars, and all planetary bodies beyond it. Firm evidence for evolved planetary systems at white dwarfs is found in the form of photospheric contamination from the accretion of planetary material, transits caused by clouds of debris, spectroscopic variability from planetesimals on ultra-short period orbits, and one volatile-rich gaseous disc formed from the evaporated atmosphere of a giant planet. These evolved planetary systems provide insight into the formation, structure, evolution, and ultimate fate of planets that are entirely complementary to, and in large parts unattainable by, the analyses of exo-planets orbiting main-sequence stars. Within this project, we will make use of the astrometric, spectroscopic and photometric observations from Gaia, DESI, WEAVE, SDSS-V and ZTF-II to carry out an ambitious and comprehensive research program of white dwarfs hosting remnants of planetary systems. (1) We will measure the bulk abundances of at least 1000 planetesimals from the spectroscopic analysis of newly discovered white dwarfs that are strongly contaminated by the accretion of planetary material, assembling detailed statistics of the composition of planetary building blocks and/or fragments. (2) We will identify dozens of minor and major planets in close orbits around white dwarfs, and we will characterise their physical and orbital properties. The combined results of both areas of research will greatly improve our understanding of the formation, structure, and evolution of planets.
Impact of chemical form of nickel ions on its molecular targets in some human cells (Chenitar)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

An ambitious and multidisciplinary project is proposed to identify on the large scale the molecular targets of different chemical forms of nickel in some human cells. For this aim, a comprehensive and multidisciplinary program is proposed, including toxicity assays, non-denaturing procedures and the development of analytical schemes based on multidimensional electrophoresis and chromatographic separation. Despite nickel is classified as carcinogenic and nickel allergy is common worldwide, the molecular mechanisms responsible of nickel toxicity are not know. In this sense, to determine the carcinogenicity potential of nickel compounds, the information about the molecular targets of nickel is critical. There is an urgent need to obtain information about the molecular target depending on the chemical form of nickel, as they are not known yet. This project will study a broad range of different chemical forms of nickel in two selected human cells. Cells will be incubated with the different chemical forms in different conditions and the cytotoxicity will be measured. In order to isolate the native nickel complexes, an optimal non-denaturing procedure of will be developed. Information about the uptake of nickel to cells will be obtained and correlated with the citotoxicity results. Lastly, the identification of the molecular targets will be carried out through the development of novel analytical strategies based on the combination of different separation techniques with different detection techniques. The great novelty of this project is based on the combination of the information obatined about nickel toxicity and nickel uptake with molecular nickel speciation. The information obtained in the project will help to future understanding of molecular mechanisms of nickel related to nickel allergy and nickel carcenogicity. Additionally, the understanding of these molecular mechanisms will also help to the understanding on the mechanisms of other metal allergies.

Keywords: nickel allergy,nickel carcinogenicity,analytical method development,molecular targets,electrophoresis,chromatography,mass spectrometry
Causes And ConseqUences of Low Urban accessibility. Defining proper policy responses (CAlCULUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

An efficient and just transport system is a key element of sustainable development and an indispensable component of coherent modern societies. Improving accessibility and reducing its disparities are the means that bridge the reduction of negative transportation outcomes with a positive response to the increased mobility needs of contemporary societies. This places accessibility at the core of the main challenges of EU’s urban areas. A proper identification of causes of low accessibility combined with a profound knowledge of the outcomes of a particular pattern facilitate the formulation of the most efficient policy response that leads towards social inclusion, an increase of well-being, and a fully-fledged citizenship of contemporary societies. The CAlCULUS project aims to deepen understanding of the causes and consequences of unfavourable accessibility patterns in order to develop a decision-support model which facilitates more efficient and just transport management. The growing potential of smart cities and the recent development of big data mining provide new opportunities for innovative analyses of accessibility and travel behaviour. The previous experience of the fellow in the field of accessibility and international comparative urban studies, together with the host’s expertise in the application of big data for transport research, create perfect conditions for the implementation of the proposed research project. The influential position of the UCM and the experience of its Scientific Culture and Dissemination Unit guarantee efficient communication of the project results to diverse target groups and facilitate public engagement. Mentoring from the supervisor, and the support of the host institution which includes dedicated training opportunities, teaching involvement, and the development of management skills, will be a milestone in a path towards research maturity and will lay the foundations for the future establishment of the fellow’s own research team.

Keywords: accessibility,transport planning,travel behaviour,smart card data,big data,social structures,social equity
Role and regulation of dendritic cell functions by Solute Carrier Transporters (TakeupSLaCk)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

Phagocytes are confronted daily with the dreaded task to respond to billions of dying cells and a plethora of external pathogens. Dendritic cells (DCs) comprise a heterogeneous group of phagocytes that are equipped with several phagocytic and pathogen recognition receptors (PRRs), and with the processing machinery to mediate efficient elimination of apoptotic or infectious cargos. This, in turn, helps to maintain tissue homeostasis and prevent autoimmunity. However, there is fast-growing evidence that DC functions also affect metabolic pathways. Moreover, we are now beginning to appreciate that phagocytes need to adapt to metabolic changes and deal with the ingested material by recruiting, among others, the membrane-bound solute carrier transporters (SLCs). SLCs are the second largest family of membrane proteins in the human genome, yet remain relatively under-studied. SLCs mediate the import and export of ions, nutrients, lipids, fatty acids or drugs, and the relevance of their functions is reflected by the vast number of diseases linked to altered expression or function of SLCs, and the many drugs that target SLCs. Using sophisticated mouse models, we will analyse the expression of SLCs in DC subsets in vivo upon engulfment of apoptotic or infectious cargos. Using cutting edge technologies, we will dissect the transcriptional and metabolic programs that dictate functions of DC subsets in both tolerogenic and immunogenic conditions. We wil address, for the first time, the role of SLCs in major DC functions such as sensing pathogens and presenting antigens to T lymphocytes for the initation of adaptive immune responses. Altogether, this study will provide new insights into SLC regulation and DC biology. This proposal has the potential not only to reveal novel aspects of the use of SLCs for drug development and therapeutics of both common and rare diseases, and to enhance the targeting of engulfment or of metabolic pathways in healthy states.

Keywords: immunogenic dendritic cells,tolerogenic dendritic cells,transcriptional programs,metabolic programs,engulfment,apoptosis,infection,homeostasis,drug development,rare diseases
Measurement and Instrumentation for Cleaning And Decommissioning Operations (MICADO)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Innovation in nuclear safety
Action type: Innovation actions
Countries involved: Italy,Germany,Italy,Belgium,France,France,France,Czechia
Call: Encouraging innovation in nuclear safety for the benefit of European citizen (NFRP-2018, 2018)
Start date: 2019-06-01
End date: 2023-02-28
Duration (months): 45.0
Total project cost (EUR): 4995373.75
EU funding (EUR): 4442162.5
Participants: 11
Project status: SIGNED

The goal of the MICADO project is to propose a cost-effective solution for non-destructing characterization of nuclear waste, implementing a digitization process that could become a referenced standard facilitating and harmonizing the methodology used for the in-field Waste Management and Dismantling & Decommissioning operations. The D&D process of nuclear infrastructures demands methods for a full traceability of waste material to improve quality management and operational safety. Precise procedures provide twofold benefits: the optimization of costs, associated with D&D, and the minimization of the dose exposure to operators and personnel. The absence of a consistent and straightforward solution to characterize all types of materials, along with the lack of an integrated solution for digitizing the enormous amount of data produced, is a critical issue. Now the systems rely on the operator’s ability to maintain high operational skills and quality assurance with precision measurements that unfortunately today very often are associating high uncertainties not allowing therefore a real optimization of the waste. The utilization of several un-automatized instruments implies taking many notes and inserting them into specific ad-hoc format and on a database manually, without the possibility to combine data including previously available legacy data’s if present. The RCMS Digi-Waste solution proposed in the MICADO project will result in a proven modular solution offering an opportunity to proactively develop a unified and standardized Waste NDA Characterization Procedure and Method that could become an international reference allowing all Nuclear Operators - Research Laboratories & Safety Authorities to facilitate their exchanges. The MICADO project involves some key EU players with major knowledge in nuclear waste having all in common the interest to converge in technologies, methods and implementing a full digitization process applied to nuclear waste management.

Keywords: nuclear waste characterization,digitization,non destructive assays,waste monitoring grid,nuclear repository,measurement and uncertainty assessment,safety,radioprotection,gamma imaging
Decrypting the role of bacterial signals in microbial interactions to enhance Lysobacter establishment in the rhizosphere (RhizoTalk)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-15
End date: 2020-09-05
Duration (months): 26.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Bacterial biocontrol agents (BCAs) are a promising alternative to chemical pesticides in sustainable agriculture. However, their use is often inconsistent in field, mainly due to the difficulty of BCAs to effectively colonize the rhizosphere and integrate in resident microbial communities. As invaders, BCAs have to face indigenous microbiota once arrived on the rhizosphere, and the establishment of interspecific interactions based on quorum sensing (QS) signals may enhance or hinder their establishment in the rhizosphere. With the objective to solve the problem of BCA inconsistency in field, our research is aimed at unveiling the response of a model BCA to main QS signals released by rhizosphere-living bacteria. To do that, we designed a straightforward working plan based on the combination of microbiology, transcriptomics and formulation technologies. We will use Lysobacter capsici AZ78 (AZ78) as model BCA and QS signals already characterized in rhizosphere-living bacteria. Firstly, we will identify main QS signaling systems included in AZ78 genome through genome mining and we will dissect the AZ78 transcriptional response to QS signals through RNA-Seq. Concurrently, we will identify bacterial strains living on tomato rhizosphere able to boost the AZ78 capacity to release antibiotics and resist UV-light, thanks to positive interactions. Finally, we will develop novel formulations of bacterial consortia (AZ78 with helper bacterial strains) incorporating also positive QS signals. The outcome of this project will be a milestone in the development of next generation BCAs relying on the interspecific interactions to favor BCA establishment in the rhizosphere. The achievement of the results will allow me to create a research group focusing on the ecology and formulations of BCAs, a topic that will meet the interest of industries investing in eco-friendly fungicides and European policy inclined to reducing the input of chemical pesticides in agriculture.

Keywords: biological control agents,rhizosphere,quorum sensing,lysobacter,genome mining,transcriptomics,granular formulations
Climate change and Geodetic deformation (GEOCLIME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-07
End date: 2021-01-06
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Environmental fluid circulation (oceans, atmosphere, hydrology) induces detectable 3D deformation of the solid Earth (several mm), known as loading effects. These are mainly seasonal, with additional shorter and longer term signals. Since climate change modifies regional and global circulation, it will also impact on loading deformation. These effects are not considered in climate projections despite their non-negligible impact e.g. for sea level rise flooding prediction. This multidisciplinary fellowship will improve understanding of the water cycle and the impact of climate change on Earth’s shape via the study of loading effects using accurate space geodesy and modelling. Combining an innovative method and highly complementary data in terms of both spatial and temporal resolution - Global Navigation Satellite System (GNSS) and space-borne gravity data (GRACE) - this fellowship will allow precise determination of loading effects and to invert for associated mass variations. This will identify the different sources, long term (e.g. post glacial rebound) and short term signals (e.g. recent variations in hydrology, ice sheets, extreme climate events) using long, highly accurate time series. This fellowship will: 1) estimate the impact of anelasticity in loading deformation models and improve and validate these forward models especially for rapid effects (hours to weeks); 2) use inverse modelling of deformation linked to climate change to better observe the water cycle, and assess local implications for sea level change and natural hazards. It will provide high level training and international exposure from the world-leading geodesy group at Newcastle University (UK), taking advantage of the host’s and fellow’s complementary expertise. It provides an invaluable opportunity for significant advances in the understanding of climate change driven crustal deformations allowing the fellow to enhance her scientific career prospects at the highest level in Europe.

Keywords: gnss,crustal deformation,space gravimetry,modelling