Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
FRAILTY OPERATIVE DEFINITION-CONSENSUS CONFERENCE (FOD-CC)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Coordination and support actions
Countries involved: Spain,France,United Kingdom,Spain
Call:  (FP7-HEALTH-2010-single-stage, 2010)
Start date: 2010-11-01
End date: 2012-04-30
Duration (months): 18.0
Total project cost (EUR): 533080.0
EU funding (EUR): 487034.0
Participants: 4
Project status: CLOSED

Frailty Operative Definition-Consensus Conference (FOD-CC) aims at celebrating a conference focused on those topics, be inclusive in its participants and reach firm conclusions. The design of the workshop must take into account 1) The need for selecting the potential variables to be included in the final definition, 2) The need to get these variables from every field of interest in regard with frailty, 3) The need to select by experts in every field, the main variables among the pre-selected variables, 4) The need of making a second selection process where the expert from the different fields of interest may argue the importance of all the selected variables in a general definition of frailty. FOD-CC will consist in two preliminary meetings, where five discussion groups (geriatricians, non-geriatricians clinicians, non-medical health workers, basic scientists and social and NGOs), composed by six participants each, will work in a separate way to extract the potentially main variables in their fields related to frailty (preliminary meeting 1) and to finally select a few of them and proposed a definition of frailty (preliminary meeting two). Afterwards, a final meeting (Consensus Meeting) will be held to reach a final proposed definition of frailty. This meeting will be attended by some of the experts, and an Advisory Committee composed by representatives (technical experts) of sound Organizations. After finishing the project, the proposed definition and biological markers will be tested (out of the project) in existing longitudinal cohorts as the Three City Study (3C Study) and Toledo Study of Healthy Ageing (ETES), conducted by two of the groups proposing this initiative. Other two cohorts would be probably added to guarantee the trans-cultural profile of the definition and its validation, out of the project as well.

Keywords: frailty,healthy ageing,biomarkers
International Network for a Digital Cultural Heritage e-Infrastructure (INDICATE)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to policy development and Programme implementation
Action type: Coordination and support actions
Countries involved: Italy,Italy,France,Greece,Spain,Egypt,Jordan,Türkiye,Slovenia
Call:  (FP7-INFRASTRUCTURES-2010-2, 2010)
Start date: 2010-09-01
End date: 2012-10-31
Duration (months): 26.0
Total project cost (EUR): 686192.0
EU funding (EUR): 599948.0
Participants: 10
Project status: CLOSED

The INDICATE project will coordinate policy and best practice regarding the use of e-Infrastructures for digital cultural heritage in countries all around the Mediterranean. The project will establish and nurture a network of common interest made up of experts and researchers in all the relevant fields, whose sustainability will be planned on a long term beyond the project duration. The network will share experience, promote standards and guidelines, seek harmonisation of best practice and policy and act as a conduit for knowledge transfer from countries with more experience of e-Infrastructures-enabled e-culture to those who are just beginning to investigate this area. The project will be rooted in the reality of research pilots and case studies which will act as exemplars and demonstrators of the issues and the processes which are relevant to establishing cultural initiatives on the e-Infrastructures platform. The results will inform a wide-reaching dissemination work-package, including two major public best practice deliverables, one international conference, three technical workshops and one policy workshop. The project builds on a wealth of experience in effective international coordination of digitisation, digital cultural heritage and e-Infrastructures-enabled culture. It takes full cognisance and advantage of e-Infrastructures and cultural projects which have gone before and will actively seek interaction and synergies with other projects in this area. The impact on international collaboration and on digital cultural heritage in the Mediterranean region will be substantial.

Keywords: e-infrastructure enabled digital cultural heritage,internation network of experts,metadata,standards,guidelines,semantic search,authetication,pilots,preservation,gis,mediterranean,policies
Universal coverage in Tanzania and South Africa: Monitoring and evaluating progress (UNITAS)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: United Kingdom,South Africa,Tanzania, United Republic of,Belgium
Call:  (FP7-HEALTH-2010-single-stage, 2010)
Start date: 2011-01-01
End date: 2016-03-31
Duration (months): 63.0
Total project cost (EUR): 3935289.12
EU funding (EUR): 3000000.0
Participants: 7
Project status: CLOSED

The goal of universal health coverage is receiving growing attention. How best to improve risk pooling and to ensure that the most socially disadvantaged receive priority in having their health care costs met, are questions yet to be answered, particularly within the African context where very few countries have achieved universal health systems. South Africa is introducing National Health Insurance, where formal sector workers will make mandatory contributions which will be pooled with allocations from general tax revenue. Tanzania is integrating existing health insurance schemes for formal and informal sector workers under the management of a single insurer. Translating such health financing reforms into intended changes ‘on the ground’ requires a well functioning monitoring and evaluation system which provides data that allow policies to be improved over time, and consequently strengthen their potential to achieve universal health coverage. This research aims to support these reforms intended to achieve universal coverage in South Africa and Tanzania by monitoring and evaluating the policy processes. Specifically, it seeks to: track policy formulation and planning for implementation; monitor the progress of policy implementation at both the national and district levels, with an emphasis on identifying implementation problems and serving as an ‘early warning system’ for policy makers and implementers; evaluate the impact of interventions aimed at progressing towards the goal of universal coverage; engage with policy makers and implementers at all levels about the research findings throughout the study period; and synthesise the results from the studies in the two countries, and compare these with experiences in other countries, to draw out policy implications on health financing mechanisms and implementation strategies supporting the achievement of universal coverage for quality health care in low- and middle-income countries.

Keywords: universal coverage,monitoring and evaluation,policy implementation,tanzania,south africa
Visual object population codes relating human brains to nonhuman and computational models with representational similarity analysis (OBJECTPOPCODESIMMM)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: United Kingdom
Call:  (ERC-2010-StG_20091118, 2010)
Start date: 2011-09-01
End date: 2017-08-31
Duration (months): 72.0
Total project cost (EUR): 1499241.0
EU funding (EUR): 1499241.0
Participants: 2
Project status: CLOSED

Two major challenges facing systems neuroscience today are (1) to relate computational brain theory with its notions of parallel computation and population-code representation to massively multivariate spatiotemporal brain-activity data as acquired with functional magnetic resonance imaging (fMRI) and cell recording and (2) to relate brain representations in animal models (e.g. nonhuman primates) to human brain representations. This project tackles these challenges with a focus on visual object recognition in human and nonhuman primates. Object recognition is a still poorly understood key problem of computational neuroscience with implications for cortical computation in general. We will test computational models and relate representational content of population codes between human and nonhuman primates by means of a novel multivariate technique called representational similarity analysis (RSA). The core idea of RSA is to characterize a given brain representation by a dissimilarity matrix of stimulus-evoked activity patterns and to visualize and statistically compare such dissimilarity matrices. In contrast to existing approaches, computational models here form an integral component of the analysis of brain-activity data. We will match up representationally homologous regions between human and nonhuman primate and determine which computational models best explain the empirical data (from human and nonhuman primate fMRI) for each brain region. Moreover this project will further develop the technique of RSA and provide an easy-to-use and freely available Matlab toolbox to the community. By richly relating brain theory to data and human to nonhuman primate studies, this project bridges major divides and will contribute to a more integrated systems neuroscience.

Keywords: visual system,human,non-human primate,population code,pattern information,computational modeling
Microbes in Allergy and Autoimmunity Related to the Skin (MAARS)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Finland,Sweden,Israel,Germany,France,Germany,United Kingdom,Estonia,United Kingdom
Call:  (FP7-HEALTH-2010-single-stage, 2010)
Start date: 2011-04-01
End date: 2015-03-31
Duration (months): 48.0
Total project cost (EUR): 7827362.24
EU funding (EUR): 5978541.3
Participants: 10
Project status: CLOSED

Allergy and autoimmunity cause increasing burden to societies worldwide. We study the effect of microbiome on the skin, the forefront barrier to environment, on autoimmunity and allergy, using atopic dermatitis (AD) and psoriasis (PSO) as paradigmatic examples. We have detailed information about the genetic risk factors, as well as the molecular and cellular players in AD and PSO, but we know very little how microbe-host interaction triggers and regulate inflammatory cascade leading to allergic or autoimmune reaction. We propose that environmental and genetic factors, characteristic to particular disease, initiate a cascade of inflammatory events through the modulation of anti-microbial defence. The dysregulation of innate as well as adaptive immune responses leads to inappropriate responses to physical, microbial or allergen challenge, finally manifesting in the clinical symptoms of AD or PSO. We propose to use high-throughput whole microbiome and transcriptomics analysis with bioinformatics and systems biology to unravel the pathways during the host-pathogen interactions which may trigger an allergic or autoimmune reaction. We will identify key microbes and molecular targets to develop novel intervention strategies to decrease and prevent the burden of allergy and autoimmunity.

Keywords: allergy,autoimmunity,microbiome,transcriptomics,high-throughput analysis,systems biology,atopic dermatitis,psoriasis
International Human Microbiome Standards (IHMS)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Coordination and support actions
Countries involved: France,Spain,United States,China,Germany,Canada
Call:  (FP7-HEALTH-2010-single-stage, 2010)
Start date: 2011-02-01
End date: 2015-01-31
Duration (months): 48.0
Total project cost (EUR): 2289894.51
EU funding (EUR): 1998886.06
Participants: 8
Project status: CLOSED

A detailed understanding of human biology will require characterisation of the human-associated microorganisms, the human microbiome, and of the roles these microbes play in health and disease. Large projects in Europe, the United States, China and Canada target these objectives, using high throughput –omics approaches. Given the complexity of our microbial communities, composed of thousands of species and differing considerably between individuals, as well as the multitude of effects they have on our biology, none of the projects can hope to achieve their comprehensive characterisation. To progress most efficiently towards this ambitious goal it is of utmost importance that the data generated in each individual project be optimally comparable across all the current projects and those yet to come. Our proposal seeks to coordinate development of standard operating procedures and protocols, which will optimize data comparisons in the human microbiome field and thus improve the synergy between all the projects. It focuses on three key aspects of data generation: (i) human sample collection, processing and identification via the associated metadata; (ii) DNA sequence quality obtained by the new generation methods from complex microbial mixtures; (iii) analysis of DNA sequence in conjunction with the metadata. Importantly, it organises public access to the standard operating procedures and protocols and enables exchanges between the users and providers of the standards. It gathers very strong international partnership that includes leaders in the field and represents the current large projects, which span three continents, Europe, Asia and America. Furthermore, it interfaces via the International Human Microbiome Consortium with additional projects from Africa and Australia. The proposal is thus highly congruent with the focus of the call, which targets omics, standards and international context.

Keywords: human samples,human metagenome,clinical metadata,dna sequence analysis,metagenomics,metagenomic sequences
European West Nile collaborative research project (EUROWESTNILE)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Spain,Austria,France,France,Italy,Italy,Russian Federation,Senegal,Czechia,Israel,Spain
Call:  (FP7-HEALTH-2010-single-stage, 2010)
Start date: 2011-03-01
End date: 2014-08-31
Duration (months): 42.0
Total project cost (EUR): 3935592.0
EU funding (EUR): 2999073.0
Participants: 16
Project status: CLOSED

West Nile virus (WNV) is one of the most evident examples of emerging/re-emerging pathogens one can nominate, which is characterized by occasional virulent epizootic outbreaks. Despite intensive research done since its first appearance in the Americas in 1999, many aspects of its molecular biology, epidemiology, ecology, pathogenesis and life cycle are still poorly understood. Being a generalist pathogen par excellence, its eco-epidemiology is extraordinarily complex, involving hundreds of different vectors and hosts, which differ between locations. In addition, as other RNA viruses lacking proofreading replication, its genome is highly variable and consequently of extraordinary plasticity. As a result, many WNV variants have evolved independently in different parts of the world. As the virus moves from one area to another, either by nature, through migrating birds, or by human influence (commerce and/or other activities), different WNV variants (lineages) from different origins can coexist and co-evolve in a particular area. This is the case in Europe, with at least five of seven WNV lineages identified to date. This situation is clearly different from that of North America. However, most studies on WNV currently come from the USA, biasing the knowledge available not only toward the virus there -a serious bias with important consequences influencing, for instance, diagnostic methods- but also to the WNV ecology in hosts and vectors. In the present Project we propose to conduct comprehensive studies on the WNV situation in Europe and affected surrounding countries that accounting for the peculiarities of WNV eco-epidemiology in this region. Moreover we will strive to cover knowledge gaps regarding its ecology, epidemiology and pathogenesis in Europe. Finally, the Project aims to develop new tools and strategies for research on treatment and prevention of WNV disease, as well as to produce new diagnostic methods, taking Euro-Mediterranean peculiarities into account

Keywords: west nile virus,virology,diagnostics,viral ecology,virulence,transmission,epidemiology,treatment,prevention
Persistent virus infection as a cause of pathogenic inflammation in type 1 diabetes - an innovative research program of biobanks and expertise (PEVNET)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Finland,Sweden,Italy,Norway,United Kingdom,United Kingdom,Sweden,France,Finland,United Kingdom,Sweden
Call:  (FP7-HEALTH-2010-single-stage, 2010)
Start date: 2011-01-01
End date: 2016-06-30
Duration (months): 66.0
Total project cost (EUR): 7901998.4
EU funding (EUR): 5999687.0
Participants: 14
Project status: CLOSED

Type 1 diabetes is caused by an inflammatory process which damage insulin-producing beta-cells in the pancreas. It is one of the most common chronic diseases and its incidence is rapidly increasing. Due to its complications it causes a significant medical and economic burden to European society. A causal association between enterovirus and type 1 diabetes has become more and more likely. The aim of the present research programme is to create a new research strategy aligned to a concerted scientific research effort and creation of a network of unique resources which makes it possible to achieve a significant breakthrough in this field. The main focus is in the detection of persistent enterovirus infection leading to inflammation and tissue damage in the pancreas and its role in mediating the inflammatory response that causes type 1 diabetes. The goal is to take the critical steps towards therapeutic translation of research findings by employing a novel research design and synergistic networks of excellence based on the combination of a multidisciplinary research strategy and availability of unique biobanks existing in Europe. This research programme will also create a completely new type of biobank which facilitates a wide range of new analyses of fresh tissues. The programme includes a strong translational component which facilitates the ongoing efforts to develop vaccines against diabetogenic enteroviruses and other targeted therapies. The program also has a wider impact on the entire field of research on pathogen-disease associations, since the same innovative research strategy can be applied to other diseases as well. Altogether, this research program will take full advantage of the excellent biobank networks and a long tradition in biomedical and clinical research in Europe and creates an exceptional opportunity to take the final steps towards proving causality in the enterovirus-diabetes association.

Keywords: enterovirus,persistence,inflammation,autoimmunity,type 1 diabetes,biobanks,genomics
EUROPEAN NETWORK for CANCER research in CHILDREN and ADOLESCENTS (ENCCA)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Network of Excellence
Countries involved: Austria,Belgium,United Kingdom,Germany,France,Italy,Germany,Netherlands,Spain,Poland,United Kingdom,United Kingdom,Italy,France,Greece,Netherlands,France,France,Sweden,Belgium,Germany,Germany,United Kingdom,Germany
Call:  (FP7-HEALTH-2010-single-stage, 2010)
Start date: 2011-01-01
End date: 2015-12-31
Duration (months): 60.0
Total project cost (EUR): 14221575.67
EU funding (EUR): 11997958.9
Participants: 34
Project status: CLOSED

ENCCA aims to establish a durable, European Virtual Institute clinical and translational research in childhood and adolescent cancers that will define and implement an integrated research strategy and will facilitate the necessary investigator-driven clinical trials to introduce the new generation of biologically targeted drugs into standard of care for children and adolescents with cancer. This will lead to more efficacious and less toxic therapies that will maximise the quality of life of the increasing number of survivors of cancer at a young age in Europe and allow them to assume their proper place in society. This biologically-driven research agenda will improve training of the clinical investigators and translational scientists of the future to spread excellence, increase capacity to participate in research and monitor outcomes across Europe. Patients and their families will be full partners and will be better informed about the need for and processes of clinical research. They will be in a better situation to care from their long term health risks for children. Drug development will be accelerated in partnership with industry through improved access to young patients with cancer, to academic expertise in care, clinical and biological research. All of this will be achieved with respect for the highest ethical and patient safety standards. ENCCA will bring all stakeholders to the table in a timely and efficacious manner. It will address the needs of all the current multinational clinical trial groups for the benefit of children with cancer. It will provide them with common tools and approaches to solve the bottlenecks in testing new therapeutic strategies for those rare diseases in a vulnerable age group and in running a competitive clinical research agenda. Ongoing efforts to coordinate EU and US clinical research will be reinforced. ENCCA will be led by the most active EU institutes in the field (31), recognised as being at the forefront of excellence.

Keywords: paediatric oncolgy,therapeutic strategy,standards,referral schemes,clinical trial,harmonisation