Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Precision Diagnostics for Predicting Therapy Response to Bispecific Antibodies (Interact-ALL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-01-01
End date: 2026-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Immunotherapies have revolutionized cancer treatment by utilizing the patient's immune system, offering hope for treating a wide range of diseases. However, challenges such as therapy resistance, poor response rates, and high costs remain. Precision diagnostics that accurately identify patients likely to benefit from specific immunotherapies could optimize treatment efficacy, reduce unnecessary treatments, and significantly decrease healthcare expenses. A major limitation of current predictive biomarkers is their focus on the abundance of individual immune components, such as T cell numbers or specific surface markers, without considering the crucial interactions among immune cells or between immune and cancer cells. Such cellular interactions are particularly relevant for the efficacy of the immunotherapeutic class of bispecific antibodies, which target cancer by facilitating direct interactions between cancer and immune cells. Traditional methods for predicting response to immunotherapies fail to account for the complexity of these cellular interactions. Our ERC-Starting Grant project introduces an innovative framework for simultaneously mapping single-cell immune landscapes and cellular interactions at a low cost and ultra-high scale. Applying this approach to pre-treatment samples from children with acute lymphoblastic leukemia undergoing bispecific antibody therapy has allowed us to identify specific cellular interactions associated with therapy response or failure. Here we suggest to refine, validate and prepare the clinical implementation of our approach with the goal to develop a novel precision diagnostic tool that accurately predicts response to bispecific antibodies.
Targeting ER Import And Activation Of Viral Glycoproteins: Towards Broad-Spectrum Antivirals (VIGILANT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Germany,Sweden,Finland,Slovenia,United States,Netherlands
Call: Pandemic preparedness and response: Host-pathogen interactions of infectious diseases with epidemic potential (HORIZON-HLTH-2024-DISEASE-08, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 7471717.5
EU funding (EUR): 7471717.5
Participants: 10
Project status: SIGNED

The VIGILANT consortium is dedicated to tackling the global threat posed by emerging viruses, exemplified by the COVID-19 pandemic and the Ebola epidemic in Western Africa. These events have emphasized the profound impact of such viruses on human health and economic stability. Moreover, anthropogenic factors, notably climate change, will result in an increase in the frequency of outbreaks caused by these viruses in the future. To address this vulnerability, the VIGILANT consortium pursues the development of antivirals with broad-spectrum activity. Pioneering research conducted by the consortium has identified the inhibition of the Sec61 channel and virus-activating host proteases as a promising strategy. The consortium's efforts are centered on addressing priority diseases defined by the World Health Organization due to their epidemic potential and the lack of countermeasures. Thus, the VIGILANT consortium aims to provide new insights into the protease dependence of emerging viruses, including Ebola virus, Marburg virus, Nipah virus, Zika virus, and Chikungunya virus. Furthermore, VIGILANT will develop inhibitors of the virus-activating proteases furin and cathepsin B/L that are safe and exert broad and potent antiviral activity in cell culture and animal models and are thus ready for clinical evaluation. Furthermore, VIGILANT will devise inhibitors targeting Sec61 and will determine breadth of antiviral activity and potential resistance mechanisms. To achieve these ambitious goals, VIGILANT has assembled an array of partners with unique resources and expertise. These partners have demonstrated success in inhibitor development, protease profiling, protein structure determination, and analysis of antivirals. By leveraging their collective capabilities, the VIGILANT consortium aims to provide important insights into ER import and activation of viral glycoproteins and to bring about a quantum leap in pandemic preparedness – the development of broad-spectrum antiviral

Keywords: broad spectrum antivirals,sec61 translocon,virus activating proteases,furin,cathepsin b l,ski 1,ebola,marburg,zika,nipah,organoids,animal models,nhp,ferret,hamster,inhibitor development
Support to all stakeholders from the Photovoltaic sector and related sectors to contribute to the SET-Plan (ETIP PV Secretariat)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Coordination and support actions
Countries involved: Belgium,Germany
Call: Support to the activities of the ETIPs and technology areas of the SET Plan (HORIZON-CL5-2021-D3-02, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 946500.0
EU funding (EUR): 946500.0
Participants: 2
Project status: SIGNED

The ETIP PV Secretariat proposal (EUPV+) is designed to re-strengthen the European Technology and Innovation Platform for Photovoltaics (ETIP PV) by implementing a strong and pro-active Secretariat which will provide effective support to the ETIP PV Governance structures and the Working Groups. It will also further work to ensure that the ETIP PV becomes the point of reference for all stakeholders, especially PV industry, but also European and Member State officials. The project shall continue integrating national or regional PV platforms, and strengthening the relations with other organizations supporting the same goals, such as EERA, but also national PV associations and all trade bodies aiming at supporting the development of the European PV industry, not forgetting the other ETIPs.

Keywords: photovoltaics,solar pv,set plan,local manufacturing
Around Braids, Categories and Distances (ABCD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: France,Australia
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 136073.04
EU funding (EUR): 136073.04
Participants: 2
Project status: CLOSED

This proposal aims at addressing classical problems about the braid group by making use of recent advances in higher representation theory. More precisely, I want to use Khovanov-Seidel categorified Burau representation and Bappat-Deopurkar-Licata's work on stability conditions to work on the faithfulness problem for the Burau representation and on the Haagerup question for the braid group. The faithfulness of the Burau representation for the 4-strand braid group is one the oldest and most tantalizing problems in braid group theory. I strongly hope that new light can be shed on it by using recent tools from higher representation theory. My strategy is to develop with Licata a ping-pong argument, which will rely on a diagrammatic description of morphisms in the category of bimodules over the zig-zag algebra. Then a fine control of the decategorification process will be needed, that I will study with Bonnafé. Braid groups also play a major role in geometric group theory, a field of research that arose under the impulse of Gromov. Amongst open questions, knowing whether the braid groups enjoy the Haagerup property is a central one, as it has ties with several open conjectures. I plan to use Bappat-Deopurkar-Licata's work on Bridgeland stability conditions on the category of representations of the zig-zag algebra to build a space with walls on which the braid groups in type A would act. This would yield a proof of the Haagerup property for braid groups in type A. Both of these work problems are major challenges in braid theory, and my approach to study them will create innovative mathematics entangling tools from several fields (geometric group theory, triangulated categories, diagrammatic algebra). This project will only be made possible thanks to the help of world-leading experts in Canberra and Montpellier, who will assist me in using mathematical tools I am not always familiar with.

Keywords: braid groups categorification zig zag algebra burau representation stability conditions geometric group theory haagerup property
Potassium-Ion electrochemical energy storage in metal-organic hybrid frameworks doped with redox and electron transport boosters (POSIDON)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia,Germany
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 2
Project status: SIGNED

Potassium ion batteries (KIBs) offer unique opportunities for low-cost, sustainable, and high-performance electrochemical energy storage required for the electrification of transportation, and for storing energy from renewable but intermittent resources. However, concerted efforts are required to tackle the challenges of KIBs, such as the short life, low energy content, and long charging time. POSIDON will leverage the versatile material toolbox of metal-organic frameworks (MOFs) and graphene derivatives (core expertise of the applicant and host institution, respectively) to design and develop efficient electrode materials, and introduce a paradigm shift in KIBs performance. POSIDON will build advanced hybrid K-ion batteries (HyKIBs) by engineering and studying 1) strategically designed cathodes based on coaxial metallic/MOF nanowires doped with redox-active molecules to boost the conductivity and capacity, and 2) sophisticated two-dimensional anodes based on graphene derivatives with dense out-of-plane and in-plane functionalities as hosts for single metal atoms, acting as nucleation centers for the improvement of reversible deposition and stripping of potassium, of potassiophilicity and impeding dendrite formation, which is catastrophic for the life-cycle and safety. These electrodes will dramatically improve the capacity, the energy content of the HyKIBs, and prolong their life. Moreover, the high porosity of MOFs and the conductivity of the envisioned electrode architectures will promote potassium diffusivity for fast-charging operation. POSIDON will deliver practical cells of HyKIB devices with high performance to pave the way towards the commercialization of potassium-based energy storage, which is vital for a low carbon, sustainable, and fossil-fuel-independent civilization.

Keywords: metal organic frameworks,graphene,potassium ion batteries,electrochemistry,electrochemical energy storage devices,
Photoelectrochemical Oxidation of Methane using Single Atom Catalysts (POMASAC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-12-01
End date: 2025-11-30
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Natural gas (primarily methane, CH4) is still a major energy source that is often simply flared into the atmosphere without being harnessed. As a cumulative result, unprecedented CH4 spikes have been reported lately in Earth’s atmosphere. Combined with the already existing Global warming concerns posed by other greenhouse gases such as CO2, CO, NOx, etc., CH4 abundance will lead to a worldwide catastrophe. Various attempts to convert and utilize CH4 into useful chemicals in mild reaction conditions have only seen limited success. In this proposal, we aim to target the CH4 molecule by fixing the CO2 molecule to produce acetic acid [CH3COOH, a high-value industrial chemical - the global acetic acid market attained a value of over 8.7 billion EUR in 2020 and is expected to grow at a compound annual growth rate (CAGR) of 5.5% from 2022 to 2027] via Photoelectrochemistry (PEC, using light and electricity) employing a new generation of heterogeneous catalysts called Single Atom Catalysts (SACs, containing abundantly available single transition metal atom embedded on transition metal oxide semiconductors that can rival catalytic efficacy of a well-defined homogeneous catalyst). To achieve this goal, we will mainly study (1) different band-energies of SACs using optical and electrochemical methods; (2) select and examine appropriate SACs with band energies that can enable CH4 oxidation and CO2 reduction; (3) examine their selectivity, efficiency, and recyclability through catalyst and reaction optimizations; (4) characterize the best performing SACs and (5) decipher the reaction mechanism with the aid of computational methods. We will disseminate the results through papers, conference presentations, public outreach events, social media, etc., while gaining several scientific and transferable skills required for career progress. A new pathway towards methane valorization is foreseen through this project, which can be highly attractive in an academic and industrial setting.

Keywords: single atom catalyst,methane,acetic acid,co2,artificial photosynthesis,oxidation,reduction
Modelling the impact of aging in sporadic Alzheimer’s disease (XenoAD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Belgium
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Understanding therapeutic opportunities in Alzheimer’s disease (AD), the most common form of progressive neurodegeneration, is limited due to lack of animal models that replicate the disease’s consecutive stages. We achieved a breakthrough by xenografting human stem cell-derived neurons into mouse brains, where they integrate and survive up to two years, developing typical AD hallmarks. Neighbouring mouse neurons remain resilient to AD, underscoring unique human neuronal features not mirrored in rodents. Significant challenges persist, particularly modelling aging, the primary and most elusive risk factor for sporadic AD. The current model also lacks human microglia, crucial carriers of genetic risk for AD. We need to measure the impact of progressive disease on neuron function, as maintaining brain function is the ultimate goal. To address these challenges, we propose a novel method of transplanting human neurons that preserve their epigenetic markers of aging, together with human microglia in double xenografts. Concurrently, we will investigate neurons from healthy aging centenarians to understand the basis of AD resilience at old age. Our research tackles critical questions: (1) How do age-associated epigenetic changes modulate disease phenotype? (2) What is the molecular basis of resilience in centenarians? (3) Do newly discovered drug targets benefit neuronal function? (4) Which blood biomarkers track the effect of experimental treatments? This study focuses on human biology, using human cells, genes, and proteins, ensuring rapid translation to clinical settings. By the project’s end, we expect to identify at least four novel drug targets and their biomarkers, validated through preclinical studies. Developing the first animal models for sporadic AD is transformative for the field, allowing to map the molecular pathways in human neurons from health to degeneration. The work will lead to new therapeutics but may also lead to cell transplantation therapies for AD.

Keywords: alzheimer s disease,xenografts,aging,models
Dynamic navigation and port call optimisation in real time (DYNAPORT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Innovation actions
Partnership: ZEWT (co-programmed)
Countries involved: Norway,Germany,Denmark,Netherlands,Portugal,Panama,Sweden,Spain,United Kingdom
Call: Integrated real-time digital solutions to optimise navigation and port calls to reduce emissions from shipping (ZEWT Partnership) (HORIZON-CL5-2023-D5-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 8837300.0
EU funding (EUR): 7153285.0
Participants: 19
Project status: SIGNED

Decarbonization of maritime transport through carbon-free fuel is a daunting and expensive process. New propulsion systems, such as wind-assisted, will contribute to fuel-savings. Still, whatever the pathway for a sustainable transition towards net zero emissions by 2050, more energy-efficient operations remain a prerequisite. This applies to the ship sailing as well as the port call processes. Efficient and viable voyage and port call optimization requires much increased cooperation between parties and overcoming several important barriers such as; charter parties and contracts enabling just in time arrivals and more explicit risk/benefit sharing; improved transparency and reduce cyber-security risks; reliable and efficient voyage and port call information sharing among all parties. Any new voyage optimization tool must take all these constraints into consideration and ensure full transparency on the arrival times to be agreed between the parties before the optimized route is activated. The goal of DYNAPORT is to develop new optimization and coordination tools for ports and ships that both reduce the ship's fuel consumption and increases port efficiency with at least 10%. KPIs will be developed to quantify and measure these savings. The tools will be built on information sharing through internationally accepted protocol standards and communication systems. To improve port efficiency as well as port approach safety, the system will integrate the port VTS in arrival and departure planning and execution. This goal is fully aligned with the Strategic research and innovation agenda for the partnership on Zero-Emission Waterborne Transport, underlining the lack of standardized technologies and infrastructure enabling operational integration with ports as one key barrier to faster decarbonization of maritime transport, but also with the IMO Strategy on the reduction of GHG emissions from ships, and wider initiatives by the EC, such as the European Green Deal.

Keywords: port call optimization voyage optimization just in time arrival cooperation communication information sharing
The Philosophy of Experiential Artifacts (PEA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1493753.0
EU funding (EUR): 1493753.0
Participants: 1
Project status: SIGNED

Ancient Greeks used one word, techne, to designate both technical and artistic practices. It is only in modern times that art gained autonomy, becoming the object of one philosophical discipline: aesthetics. However, the emergence of mass media, and then of digital media, has brought art close to technology, challenging its autonomy. In this situation, some basic philosophical questions about art regain centrality: Why art? What is art for? What is the role of art in a technological society like ours? The traditional answer stresses the uniqueness of art, pointing to the essential difference between artworks and technical artifacts. The increasing interchange between art and technology, however, encourages us to question this statement, pursuing an alternative strategy. The hypothesis is that artworks belong to a technical kind which has been overlooked so far: the kind of experiential artifacts whose function consists in triggering experiences. Art is severed from technology only if one focuses on artifacts such as drills or lathes whose function consists in producing concrete effects. Yet, once experiential artifacts have been recognized, one can fruitfully connect art to technology, rethinking forms of art as techniques for generating different types of experiences. The PEA project launches the philosophy of experiential artifacts as a new area of inquiry in which the relationship between art and technology can be properly theorized, thereby offering a new conceptual toolbox for historical and empirical research. This will be done through a fourfold methodology in which aesthetics and the philosophy of mind analyze the experiences that experiential artifacts are meant to trigger, while metaphysics and the philosophy of technology investigate the structure in virtue of which they perform this function. PEA will thus reconceptualize artworks as technical artifacts that we value for the way in which they enable us to enrich, share and coordinate our experiences.

Keywords: philosophy of technology phenomenology philosophy of art