Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Transnational Force of Law (TFL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-08-31
Duration (months): 72.0
Total project cost (EUR): 1943502.0
EU funding (EUR): 1943502.0
Participants: 1
Project status: CLOSED

Global law is changing fundamentally. New forms of law creation, new modes of adjudication, and new enforcement mechanisms in the transnational constellation challenge our understanding of law as a state-based phenomenon. The attending boom in research on transnational law has significantly contributed to our understanding of its structure and functioning. However, existing normative accounts of transnational law often still rely on a conception of legal force that originates in the state or a polity. As a result, a distinctive and compelling normative theory of transnational law has yet to be realized. TFL will fill this gap by developing a normative theory of transnational law based on a novel concept of the transnational force of law. This concept has two dimensions: In a descriptive sense, the transnational force of law accounts for the plurality of societal legal forces in the transnational legal arena, beyond public/private and state/non-state dichotomies. In its normative dimension, it requires a sophisticated normative foundation for all of these societal legal forces that takes into account polycentric claims for legitimacy, efficiency, and justice. This is what our normative theory of transnational law will provide. This theory will be operationalized in three case studies on areas of transnational law where new forms of rulemaking coincide with a broad societal discussion on their normative foundation: financial markets (lex financiaria), internet governance (lex digitalis), and agricultural markets (lex agraria). The analysis will proceed in two steps: (1) descriptively, systemizing the respective transnational legal phenomena in terms of legislative, judicial, executive transnational legal forces, and identifying normative conflicts with human, societal and environmental spheres around normative claims for legitimacy, efficiency and justice; (2) normatively, developing ways to realize these demands within these legal arenas.
Rational Design and Construction of Viral Based Products (SynVaccine)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Israel
Call: Dedicated support to biotechnology SMEs closing the gap from lab to market (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In order to be fully effective as an oncolytic virus or vaccine, achieving of precise and specific traits are pivotal. However, current technologies are limited to the confines of a virus’s existing biological make-up. They are left with manipulation of genes within the virus e.g. deleting and adding proteins, inability to manipulate silent codes etc. where achievement of such precision is simply not possible from such naturally-rooted manipulation. The SynVaccine solution taps into 3 billion years of viral evolutionary data which is continually updated, ensuring the highest degree of accuracy on rules that govern all viruses found today. Through this, it becomes the only solution to govern the rules of viruses on a cellular level, giving the important ability to precisely dictate the traits and behaviour of the newly designed, bottom-up, created viruses. As a result, only the most effective oncolytic viruses and vaccines are ever produced, ensuring the highest levels of treatment and immunity. We have invested over €3.1 million into the development and testing of our solution to ensure its robustness and efficiency, and thus move into the next stage of specific drug development. Our management and scientific leadership capacity involves 10 multi-disciplinary experts in the fields of; entrepreneurship, virology, synthetic biology, computational biology, engineering and automation. The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of our SynVaccine derived solutions, and their market uptake.

Keywords: synthetic biology,virology,oncolytic virus,vaccine
The Agile Innovation solution to revolutionise the way people connect, collaborate and create disruptive innovations throughout a company’s ecosystem to unlock its full potential (innosabi GALAXY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-12-01
End date: 2021-11-30
Duration (months): 24.0
Total project cost (EUR): 2568750.0
EU funding (EUR): 1798125.0
Participants: 1
Project status: CLOSED

In Innovation Management, all large corporations face the same challenge: they lose the overview of available competencies, knowledge, and direct contact to their stakeholders for innovation. Hierarchic structures lead to long decision-making that cripples the corporation in their innovation and product development. To sustain in international competition, they need digital, simple and effective solutions to implement open, agile innovation management. innosabi is a place where talented individuals build the tools and methods to change the way ideas and innovations emerge. We are one of Europe’s leading providers of software solutions for innovation management with many well-known customers, like Daimler, Bayer, Siemens, and Allianz. innosabi is more than software. We don’t just develop the technology for Agile Innovation. We create new methods, advocate the power of open collaboration, and share our insights with politics, corporations, and other like-minded companies. We want to actively shape the future as pioneers and thought leaders. Not only with our technology but by living and practicing the mindset and principles we believe in. In collaboration with our pilot customers Bayer and Siemens, we develop the next disruptive solution for agile innovation: innosabi GALAXY. innosabi GALAXY unites all existing tools for collaboration with employees, suppliers, and customers, and implements external knowledge databases and communities, like CrunchBase or LinkedIn. By using our platform, customers could generate and process proposed ideas 2x faster, increase the participation rate by 5, have 200x more employees participating in idea generation, gain market insight 6x faster and reduce the time to market of products by 30%. With a year on year growth of our turnover of 40% since 2015, innosabi GALAXY and the SME Instrument funding we will reach the next milestone to boost company growth from 2.8 M€ (2018) and 45 employees to a turnover of 16.3 M€, 140 employees in 2023.

Keywords: agile innovation,open innovation,crowdsourced innovation,innovation management,idea generation,collaboration
High-Performance Monte Carlo Methods for SAFEty Demonstration- From Proof of Concept to realistic Safety Analysis and Industry-like Applications (McSAFE)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Nuclear safety
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Sweden,Belgium,Finland,France,Czechia,Czechia,Netherlands,United Kingdom
Call: Continually improving safety and reliability of Generation II and III reactors (NFRP-2016-2017-1, 2016)
Start date: 2017-09-01
End date: 2020-08-31
Duration (months): 36.0
Total project cost (EUR): 3140393.75
EU funding (EUR): 2981592.23
Participants: 12
Project status: CLOSED

Considering the priority topics of NUGENIA and the achievements of the EU HPMC project, the overall objective of the McSAFE project is to move the Monte Carlo based stand-alone and coupled solution methodologies (advanced depletion, optimal coupling of MC-codes to thermal-hydraulic solvers, time-dependent Monte Carlo and methods and algorithms for massively parallel simulations) to become valuable and widespread numerical tools for realistic core design, safety analysis and industry-like applications of LWRs of generation II and III. On one hand, the envisaged developments will permit to predict important core safety parameters with less conservatism than current state-of-the-art methods and on the other hand, it will make possible the increase the performance and operational flexibility of nuclear reactors. Last but not least, this kind of projects fosters the dissemination of knowledge from experienced researchers to young engineers, scientists as well as master and doctoral students. The McSAFE project is planned to be a research and innovation action. Even though the applications foreseen for this period are all focused on Generation II, the codes and methods to be further developed and validated can be applied to Gen-III and Gen-IV reactors in a straight-forward manner. In addition, the McSAFE tools and methods are also applicable to research reactors (core design optimisation and safety features evaluation), where the complicated geometry and physics of the core can be adequately simulated only by Monte Carlo codes.

Keywords: monte carlo methods,thermal hydraulics,pin mechanics,multi physics coupling,high performance computing,safety analysis,core design,depletion
Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis (CarBon)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Ireland,Ireland,Germany,Italy,Belgium,Netherlands,United States Minor Outlying Islands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-01-01
End date: 2020-12-31
Duration (months): 48.0
Total project cost (EUR): 3607596.36
EU funding (EUR): 3607596.36
Participants: 14
Project status: CLOSED

A well-functioning locomotor system is essential for human well-being. This is an important consideration in our aging population with the increased associated costs of ensuring high quality of life. Many people suffer from diseases of the locomotor system, such as bone defects or osteoarthritis, for which current treatments are insufficient. To develop new treatments, CarBon includes 6 academic partners, 3 companies and 3 charitable foundations, working together to train 14 young scientists. We will combine knowledge from the fields of tissue engineering, cartilage and bone developmental biology and pathobiology using skills from the disciplines of cell biology, computational modelling, biotechnology (bioreactors, biomaterials) and drug discovery. In a multifactorial approach the network of young scientists will identify the biological and physical factors that determine the fate of cartilage. Understanding and controlling the dual character of cartilage is pivotal: insufficient transition impairs bone healing, and undesired transition to bone leads to osteoarthritis. State of the art in vitro, in silico and in vivo models will be uniquely combined to elucidate how this transition is orchestrated and how it can be modulated. The main objectives of CarBon are: - To establish a network of 14 highly skilled early stage researchers (ESRs) equipped with essential knowledge, scientific expertise, transferable skills and societal awareness as a foundation for their future careers. ESRs will be trained in cutting edge technology, communication, intellectual property and valorisation. - To understand cartilage to bone transition, to identify targets to develop novel functionalised biomaterials and to discover therapeutic drugs that either prevent or stimulate cartilage to bone transitions. This will lead to new treatment options for large bone defects and osteoarthritis.

Keywords: cartilage,bone,osteoarthritis,bone healing,tissue engineering,biomaterials,in silico tissue repair
Tracking the path of the Agricultural Revolution from England to Continental Europe: changes in pig husbandry from the Late Medieval to Early Modern period as a marker of socio-economic transformation (Sus.Post-Med)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

The phenomenon known as the English Agricultural Revolution (18th century) brought significant technological changes in farming practices, such as breed improvements and adoption of more efficient breeding strategies, which are not only the foundation of modern food production systems, but also fundamentally changed human life and shaped our current relationship with animals. This project will use pigs, one of the most common domestic animals, often associated with cultural choices and social status, as a proxy to investigate A) how changes in pig management, which originated and developed in England, spread to Continental Europe and B) the way in which pig husbandry practices were influenced by, and adapted to, the changing economy and society that characterized the transition between the Late Medieval and Early Modern period (1400-1800 AD). This will be done by comparing data from England, where the Agricultural Revolution began, and Bavaria in southern Germany, chosen due to a strong tradition of pig husbandry during the Medieval period and a lack of studies on this topic, making it the ideal ground for investigation. This project will identify the reasons, timing and geographic variation in the response of pig husbandry practices to socio-political changes including the progressive intensification of production, changes in pig size and shape, the generation of intensive sty-keeping feeding regimes and the introduction of new pig stock. To achieve this, the project will undertake a thorough investigation of pig body size and shape; combine biometrical data with Geometric Morphometric analysis to establish if genetically different stock was introduced; complement the zooarchaeological data with stable isotopes analysis to investigate changes in the way pigs were managed; and strive to understand the chronological and geographic variability in the consequences of the transition from the Medieval period to the early Modern age, precursor of the contemporary world.

Keywords: zooarchaeology,stable isotopes,geometric morphometrics,biometry,late medieval,early modern age,england,southern germany
Cognition in an Insect Brain (COGNIBRAINS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France,France
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2020-07-01
End date: 2025-12-31
Duration (months): 66.0
Total project cost (EUR): 2870839.0
EU funding (EUR): 2145339.0
Participants: 3
Project status: SIGNED

There is a common perception that larger brains mediate higher cognitive capacity. Social insects, however, demonstrate that sophisticated cognition is possible with miniature brains. Honeybees display higher-order learning such as categorization, non-linear discriminations, concept learning and numerosity, which are unique among insects. These capacities are mediated by a miniature brain with only 950 000 neurons. Despite extensive behavioral analyses, no study has attempted to elucidate the neural mechanisms underpinning the higher-order learning of bees. Our current breakthrough establishing virtual-reality protocols for tethered honeybees offers a unique opportunity to uncover the minimal circuits that mediate higher-order forms of cognitive processing in the brain of a behaving bee. We have recently shown that bees learn to solve elemental and non-elemental problems in this experimental context, which allows integrating behavioral, neurobiological and computational approaches to unravel the neural mechanisms underlying non-elemental learning in the honeybee. I will combine behavioral recordings of bees learning non-linear discriminations and relational rules in a virtual reality environment, with access to their brain via multi-photon calcium imaging and multielectrode recordings of neural populations. I will determine the neural circuits of elemental and non-elemental visual learning along the visual circuits of the bee brain, and the necessity and sufficiency of these circuits for these capacities via selective knockdown and rescuing via wavelength-selective multi-photon uncaging of neurotransmitters. Data will be fed into computational models to test hypotheses about minimal neural architectures for visual cognition, working towards whole-brain modeling. This project will expand the information available on the neurobiology of insect learning, and will provide the first integral characterization of the mechanisms underlying cognition in a miniature brain.

Keywords: cognition,higher order learning,invertebrates,insects,honey bee
Structural basis for the therapeutic efficiency of optimal-affinity T cell receptors (TCRabX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Australia
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-08-01
End date: 2022-07-31
Duration (months): 36.0
Total project cost (EUR): 264110.4
EU funding (EUR): 264110.4
Participants: 2
Project status: CLOSED

Demographic change includes population ageing, and incidence rates begin to increase for many types of cancer in middle-aged and elderly people. Traditional cancer treatment includes surgery, chemotherapy, and radiation therapy, while tumour immunotherapy by T cell receptor (TCR) gene transfer represents an alternative form of treatment. The transfer of tumour-specific TCR genes into patient’s peripheral blood lymphocytes targets cancer specifically and effectively. But while patient-derived low-affinity TCRs do not show therapeutic activity, optimal-affinity TCRs, as isolated from newly-generated antigen-negative humanized mice with a diverse human TCR repertoire, can effectively delay tumour regression. X-ray crystallography is a powerful tool of structural biology, which helps researchers to identify the three-dimensional (3D) structures of biological macromolecules such as TCRs complexed to their cognate peptide-loaded major histocompatibility complex (pMHC) molecules. Recent research uncovered the docking topologies of naturally selected TCRs, but therapeutically efficient optimal-affinity TCRs recognizing tumour-associated self-antigens, have not been analysed to date. The exceptional specificity of TCRs is determined by three complementarity-determining regions (CDRs) of the TCR alpha- and beta-chains. Biomedical research on TCR gene therapy and design of future clinical trials will hugely benefit from the identification of CDR-mediated contact points made between therapeutic TCRs and the pMHC on their target cells. TCRabX is an interdisciplinary research project investigating the 3D structures of 13 TCRs complexed to MHC-I or MHC-II, respectively. It connects innovative clinical immunology research in Berlin/Germany and world-class structural biology research in Melbourne/Australia. The proposed research will enhance the health and well-being of citizens in Europe and worldwide by supporting the advancement of cancer immunotherapy approaches.
Code Sanitization for Vulnerability Pruning and Exploitation Mitigation (CodeSan)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1499970.0
EU funding (EUR): 1499970.0
Participants: 1
Project status: SIGNED

Despite massive efforts in securing software, about 60 security bugs are publicly reported each month. Systems software is prone to low level bugs caused by undefined behavior (memory corruption, type confusion, or API confusion). Exploits abuse undefined behavior to execute attacker specified code, or to leak information. We propose code sanitization (CodeSan), a comprehensive approach to improve code quality. CodeSan will sanitize software by (i) automating bug discovery during development through software testing and (ii) protecting deployed software through reflective mitigations. CodeSan trades formal completeness for practical scalability in three steps: First, policy-based sanitization makes undefined behavior (through violations of memory safety, type safety, or API flow safety) explicit and detectable given concrete test inputs. Second, automatic test case generation increases testing coverage for large programs without the need for pre-existing test cases, enabling broader and automated use of policy-based sanitization. Third, for deployed software, reflective mitigations place runtime checks precisely where they are needed based on data-flow and control-flow coverage from our testing efforts. CodeSan complements formal approaches by protecting software that is currently out of reach due to its size, complexity, or low level nature. CodeSan is a compelling, comprehensive, and adaptive approach to thoroughly address undefined behavior for complex software. The three proposed thrusts complement each other naturally and will immediately guard large software systems such as Google Chromium, Mozilla Firefox, the Android system, or the Linux kernel, making them resilient against attacks. In line with PI Payer’s track record on open sourcing his group’s research artifacts on cast sanitization, transformative fuzzing, or control-flow hijacking mitigations, all prototypes produced during CodeSan will be released as open-source.

Keywords: software security,policy based sanitization,automatic test inference,fuzzing,software mitigation,system security