Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Myopia: Fundamental understanding needed (MyFUN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,Ireland,Germany,Germany,Spain,Germany,Sweden
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 3544115.04
EU funding (EUR): 3544115.03
Participants: 9
Project status: CLOSED

The proposed ETN “Myopia: fundamental understanding needed” (MyFUN) provides an international, interdisciplinary platform to train young scientists at the interface of physics and biology, to study unresolved questions about the visual control of eye growth. It has been extensively documented that the growth of the eye is controlled by closed-loop visual feedback, using retinal image defocus as an error signal. However, with tense education, predominant indoor activity and extensive near work, the eyes of young people grow too long and become near-sighted (myopic), reaching a prevalence of 95% in some Asian cities and 50% at German universities. While myopia is clearly a civilization disorder, it is strikingly unclear by which visual stimuli it is triggered, and how it can be stopped. Emerging optical interventions have still only moderate effects. There are fundamental questions, like “Why does myopia not limit itself?”, “Why does undercorrection not reduce its progression?”, “Why are the effects of new spectacle designs to inhibit myopia so small?”, “What determines when it starts and can we find biological markers to predict myopia in individual cases?”. We propose a scheme of novel experiments, divided into 14 research projects that all have sufficient scientific depth and merit to merge into 14 successful PhD theses. The answers to the research questions will fundamentally improve our understanding of myopia, will be recognized worldwide and will represent a major contribution of the European Community to the global problem of the rising incidence of myopia. Our consortium consists of 7 Beneficiaries, combining the expertise of 5 academic partners with excellent research and teaching records and 2 fully integrated private sector partners. MyFUN will be supported by a management team experienced in multi-site training activities and counselled by a scientifically accomplished External Advisory Board.

Keywords: physiological optics,adaptive optics,ocular optical aberrations,psychophysics,visual processing,refractive error,accommodation,myopia,retina
All Atlantic Ocean Sustainable, Profitable and Resilient Aquaculture (ASTRAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: Research and Innovation actions
Countries involved: South Africa,Spain,Ireland,Argentina,Ireland,Norway,Norway,France,France,Brazil,United Kingdom,Portugal,Nigeria,United Kingdom
Call: All Atlantic Ocean Research Alliance Flagship (H2020-BG-2019-2, 2019)
Start date: 2020-09-01
End date: 2024-09-30
Duration (months): 49.0
Total project cost (EUR): 7939354.88
EU funding (EUR): 7939354.88
Participants: 20
Project status: SIGNED

ASTRAL will develop new, sustainable, profitable and resilient value chains for integrated multi-trophic aquaculture (IMTA) production within the framework of existing, emerging and potential Atlantic markets. The proposal gathers four IMTA labs including open offshore (Ireland, Scotland), flow-through inshore (South Africa) and recirculation inshore (Brazil) systems and one prospective IMTA lab (Argentina), focusing on a regional challenge-based perspective, including fish, mollusc, echinoderm, crustacean and algae species. ASTRAL will increase circularity by 50-60% compared to monoculture baseline aquaculture and will provide a circular business model, boosting revenue diversification for aquaculture producers increasing profitability by at least 30%. New and improved innovative technology will be developed, including biosensors, sensors, IoT and an AI data analytics platform to be validated at IMTA labs at TRL 5. Potential environmental and climatic risks for Northern and Southern Atlantic regions will be addressed, delivering a monitoring programme and recommendations for Harmful Algal Blooms (HABs), pathogens and microplastics. ASTRAL will deliver an ambitious and gender-sensitive human capital development plan (HUCAP) which will improve professional skills and create a highly trained workforce. ASTRAL will share, integrate and co-generate knowledge, technology, practices and efforts with and for society, oriented towards pro-poor and gender-sensitive development. A collaborative ecosystem will be provided within the project framework bringing together and connecting industrial partners, SMEs, scientists, policy makers, social representatives and other relevant stakeholders promoting data exchange, knowledge sharing and business opportunities.

Keywords: new value chains,new species,imta,circularity,zero waste,emerging pollutants,climate change,monitoring,human health,atlantic,belem statement
A SYnaptically connected brain-silicon Neural Closed-loop Hybrid system (SYNCH)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Israel,Italy,Italy,Switzerland,United Kingdom
Call: FET Proactive: emerging paradigms and communities (H2020-FETPROACT-2018-01, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 4277868.75
EU funding (EUR): 4149612.75
Participants: 8
Project status: SIGNED

The brain, with its remarkable computational properties, provides animals with capabilities of physical autonomy, interaction and adaptation that are unmatched by any artificial system. The brain is a complex network that has evolved to optimize processing of real-world inputs by relying on event-based signaling and self-reorganizing connectivity. Spikes (the events) are transmitted between neurons through synapses which undergo continuous ‘birth’-‘death’ and adjustment, reconfiguring brain circuits and adapting processing to ever changing inputs. The scientific and technological objective of the project is to create a hybrid system where a neural network in the brain of a living animal (BNN) and a silicon neural network of spiking neurons on a chip (SNN) are interconnected by neuromorphic synapses, thus enabling co-evolution of connectivity and co-processing of information of the two networks

Keywords: memristor,neuroinformatics,nanotechnology,artificial intelligence,neural network,plasticity,chip
Characterisation and quantification of O6-alkylguanine DNA adducts derived from nitrosated amino acids: Risk factors in colorectal cancer. (O6-alkylguanines)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The exposure of DNA to alkylating agents can produce base adducts such as O6-alkylguanines, that if not repaired, can lead to a variety of effects including toxicity, mutagenicity and cancer. Although exposure may be significant for certain individuals such as workers in the chemical industry and smokers, all individuals are exposed to alkylating agents from dietary components or that derive from reactive intermediates formed endogenously. For example, nitrosation of dietary amines, amino acids and their derivatives can produce reactive alkylating agents that can result in the formation of a variety of DNA base adducts. One such adduct, O6-carboxymethylguanine (O6-CMG) has been directly correlated to dietary levels of red meat, a known risk factor for developing colorectal cancer, the second most common cancer in Europe. This proposal will use novel synthetic oligodeoxyribonucleotide (ODN) and nucleoside standards to develop highly sensitive mass spectrometry-based analytical methods to identify and quantify levels of specific O6-alkylguanine adducts in DNA. This methodology will enable links to be made between exposure and cancer risk, lead to the identification of novel predictive biomarkers and benefit the assessment of human health at both the individual and population level, paving the way for more informative monitoring studies.

Keywords: dna damage,o6 alkylguanine,alkylation
Commercialisation of dental medical device for measuring salivary pH (Medika)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Hungary
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2019-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Oral hygiene is very important for health and well-being of humans. The global market of home dental hygiene products is more than 30 billion USD world-wide, with an estimated increase of 8% annually (CAGR). Several recent studies have proved that salivary pH is a diagnostic biomarker of oral and even some gastroenterological diseases. The deviation of salivary pH from the normal value of 7.2 indicates pathological status. However, the self-measurement of salivary pH is very difficult, even impossible, since no device is commercialised for this purpose. Salivary pH is now usually measured from spittle using pH indicator paper (lacmus). This measurement is not accurate enough, and difficult to carry out by patients at home. We have developed and designed an easy-to use medical device for measuring the salivary pH in the mouth. The new device is revolutionary ergonomic, have data storage and transfer capabilities, connection to smart devices, accurate (0.1 pH), ball-pan-sized and accessible for visually impaired (Braille writing). We have protected the design and participated in several start-up events, where we won different local awards. Medika device is ground-breaking, creating new market, as it will be the first self-measurement device for measuring salivary pH at home. It will help dentists to measure and record the pH of saliva for large number of patients routinely and remotely before and after dental surgery. Its use by the wide public will prevent or avoid worsening of several oral and gastroenterological diseases. The aim of this phase 1 project is to make a feasibility study for both the technical and business development actions planned for the commercialisation of Medika device: to specify the software and the prototype, to prepare for clinical validation, to refine our business plan and to prepare the project plan for an SME Instrument Phase 2 application.

Keywords: salivary ph measurement
Development of a fintech saving and investment application based on data-driven learning algorithms and blockchain technology (GOIN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The financial sector is changing at great speed. New technologies and the entry into force of regulations such as PSD2 and the General Data Protection Regulation (GDPR) will bring about the biggest changes to the financial system in decades. In this context, Goin has merged as the most awarded seed fintech startup, with a scalable and cutting-edge technology with data-driven Learning (High Performance Algorithm) and blockchain, to be used by Millennials in order to save and invest money without knowledge about finances. Goin has tested this product in Spain with limited functionalities and has as internationalized to Italy in recent months. With this project, Goin hopes to scale-up this technology and expand it to other major European cities, to take advantage of the growth opportunity of the fintech sector, which expects a 20% annual growth in the upcoming years.

Keywords: blockchain,robo advisor,cryptocurrency investment,savings,crowdlending
Toward Precision Toxicology: New Approach Methodologies for Chemical Safety (PrecisionTox)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Belgium,Finland,Latvia,France,United States,United Kingdom,United Kingdom,United Kingdom
Call: Advancing the safety assessment of chemicals without the use of animal testing (H2020-SC1-2020-Single-Stage-RTD, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 19305583.75
EU funding (EUR): 19305583.75
Participants: 15
Project status: SIGNED

The goal of PrecisionTox is to advance safety assessment of chemicals without the use of animal testing by establishing a new, 3Rs-compliant, cost-effective testing paradigm for chemical safety assessment — Precision Toxicology — that identifies molecular key event (KE) biomarkers predictive of chemically induced adverse health effects in humans and facilitates their uptake into regulatory and industry practice. This goal is supported by three core concepts: PhyloToxicology, which replaces mammal models with an evolutionarily diverse suite of non-sentient animal species from across the tree of life; Quantitative Susceptibility, which determines safety factors based on genetic variability; and Embedded Translation, which engages key stakeholders in project planning, selection of chemicals for investigation, and case studies for regulatory application. We accomplish this goal through six objectives: ● Stakeholder Integration, embedding the Stakeholder Advisory Group in project management (WP1); ● Comparative Toxicology, utilising high-throughput testing methods across five non-sentient species and human cell lines to observe toxic response (WP2); ● Molecular Data Production, applying metabolomics and transcriptomics to comparative toxicology samples to trace adverse outcomes via the molecular key events preceding them (WP3); ● Quantitative Susceptibility, applying quantitative genetics and gene expression profiling to understand variation in individual susceptibility and develop empirical exposure thresholds (WP4); ● Biomarker Discovery, PrecisionTox Data Commons, and NAM Toolbox, using machine learning to identify biomarkers for molecular key events and creating the dissemination and translation products for their use (WP5); and ● Regulatory Analysis and Application, partnering with JRC and regulatory agencies to identify opportunities for applying Precision Toxicology within existing regulatory structures and develop draft guidance for industry use and reporting (WP6).

Keywords: new approach methodology,adverse outcome pathways,mechanistic toxicology,phylogenetic toxicology,systems toxicology
Molecular Robotics for Synthesis and Catalysis (RoboCat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The aim of this project is to design, synthesize and investigate the operation of synthetic molecular machines capable of performing sophisticated tasks in chemical synthesis. The molecular machines are inspired by biological systems, where substrates are shuttled between different enzymatic sites, undergoing chemical transformations at each step. Control of substrate position allows for reactions to occur in a specific sequence, with the molecular machine dictating the selectivity of each successive chemical reaction. The project both seeks to optimize the structure of the molecular machines for use as a synthetic platform and demonstrate their usefulness for synthesis and catalysis in model reactions. The successful demonstration of this concept would mark the beginning of a fundamentally new approach for the construction of molecules.

Keywords: molecular machines,host guest chemistry,molecular devices
Demonstrative process for the production and enzymatic recycling of environmentally safe, superior and versatile PHA-based rigid packaging solutions by plasma integration in the value chain. (BioSupPack)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Innovation actions
Partnership: BBI (Art-187)
Countries involved: Germany,Spain,Germany,Germany,Spain,Spain,Ireland,Italy,Italy,Greece,Belgium,Greece,Belgium,Czechia,Czechia,Portugal
Call: Demonstrate superior bio-based packaging solutions with minimal environmental damage (H2020-BBI-JTI-2020, 2020)
Start date: 2021-06-01
End date: 2026-03-31
Duration (months): 58.0
Total project cost (EUR): 8591110.69
EU funding (EUR): 6403796.6
Participants: 18
Project status: SIGNED

BioSupPBioSupPack goal is to deliver novel, cost-competitive and versatile bio-based packaging solutions based on PHA, that demonstrate high-performance for the packaging of food, cosmetics, homecare and beverage products as well as no environmental damage during & after their use, by means of: 1. Optimization of PHA based formulations based on significantly use of >85% w/w of renewable resources. 2. Upscale the different conversion processes as well as post-consumers waste sorting & recycling following advanced industry 4.0 approach. 3. Broad the range of rigid packaging applications by tailoring biobased materials & packaging properties through the optimization of the formulations in combination with plasma technology or grafted coatings. 4. Integrate plasma technology in 3 different points of the value chain(biomasss pre-treatment, packaging production & packaging waste pre-treatment) increasing: i)PHB production yield, ii)PHB purity, iii) packaging performance(high oxygen & water barrier) and iv effectiveness & yield of enzymatic recycling. 5. Demonstrate and increase recyclability through:i) setting up a real-time monitoring system for the selective separation of developed packaging after its use; ii) mechanical recycling of industrial scraps and selective enzymatic recycling of packaging waste as the best EoL, with the final recovery of carbon sources for feedstock fermentation. Thus, the new packaging is environmentally safe(sustainable and improved value from enzymatic recycling) and contributes to Circular Economy(CE). 6. Establish a new value chain including the development of logistics and management of both the brewery and packaging waste. Complying with the industry needs (cost/performance competitive vs. fossil-based non-biodegradable counterparts and legislative compliance),as well as with consumers´ awareness, BioSupPack will have a great impact on EU bioplastics & end users’ sectors, the biorefineries and biotechnology industries and on the society.

Keywords: phb and high performance rigid packagin,plasma,pha coatings,fatty acid grafting,post consumers waste sorting and selective enzymatic recycling eol,brew spent grains bsg biomass feedstock
European Leadership in Cultural, Science and Innovation Diplomacy (EL-CSID)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Singapore,Belgium,Slovenia,Belgium,Türkiye,United Kingdom,Kazakhstan
Call: European cultural and science diplomacy: exploiting the potential of culture and science in the EU’s external relations (H2020-INT-SOCIETY-2015, 2015)
Start date: 2016-03-01
End date: 2019-02-28
Duration (months): 36.0
Total project cost (EUR): 2362500.0
EU funding (EUR): 2362500.0
Participants: 10
Project status: CLOSED

The European Union has made a major start articulating the relevance of cultural and science for its external relations. What has yet to be done, however, is to make explicit the assumptions underpinning much of this work on cultural and science diplomacy and to codify and articulate it as part of a systematic and strategic approach to understanding the direction of travel of science and cultural diplomacy that locates developments in these fields within the evolving global and EU external relations context. EL-CSID will do this, with the added ambition to identify how the Union and its member states might collectively and individually develop a good institutional and strategic policy environment for extra-regional culture and science diplomacy. Hence, the over-arching objectives of this proposed project are threefold: 1) To detail and analyse the manner in which the EU operates in the domains of cultural and science diplomacy in the current era; comparing its bilateral and multilateral cultural and science ties between states, regions, and public and private international organisations. 2) To examine the degree to which cultural and science diplomacy can enhance the interests of the EU in the contemporary world order and to identify: (a) How cultural and science diplomacy can contribute to Europe’s standing as an international actor; (b) Opportunities offered by enhanced coordination and collaboration amongst the EU, its members and their extra-European partners; and (c) Constraints posed by economic and socio-political factors affecting the evolving operating environments of both science and cultural diplomacy. 3) To identify a series of mechanisms/platforms to raise awareness among relevant stakeholders of the importance of science and culture as vehicles for enhancing the EU's external relations. The research will generate both scholarly work and policy-oriented output which will be disseminated through an extensive and targeted dissemination programme.

Keywords: diplomacy,science,culture,innovation,leadership