Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
FLoAtinG offSHore wInd oPtimization for commercialization (FLAGSHIP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Spain,Germany,Spain,Spain,Spain,Norway,Norway,Norway,Norway,France,Denmark,United Kingdom
Call: Demonstration of innovative technologies for floating wind farms (H2020-LC-SC3-2020-RES-IA-CSA, 2020)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 34929400.0
EU funding (EUR): 24920289.5
Participants: 18
Project status: SUSPENDED

The main aim of FLAGSHIP project is to validate and demonstrate a cost-effective 10MW Floating Offshore Wind Turbine (FOWT) to ensure imminent LCOE reduction in the range 40-60€/MWh in 2030 driven by economies of scale, competitive supply chains and a variety of innovations. The concept beyond is the first ever demonstration of a 10MW FOWT that will be demonstrated at a 1:1 scale in the Norwegian North Sea. It is a robust and innovative semi-submersible concrete floating platform that include easy-to-install anchoring design, novel moorings and mooring configuration, designs as well as new cable designs in with optimised installation and life management procedures. Consequently, this innovative demonstrator, as a pre-commercial windfarm located in the harsh conditions of the North Sea, will be the starting point for the large-scale assembly for 500 MW future commercial FOW farms, ensuring its feasibility to other specific locations in the Atlantic Ocean, Mediterranean and Baltic seas. In this context, the successful development will provide a fast maturing solution which could exploit untapped wind resources located in offshore locations not economically attractive today. For this purpose, the knowledge generated by FLAGSHIP and the results of the demonstrative scenarios, will be very important for the industrialisation of floating offshore wind farms. Technology demonstration can only be brought to the required commercial maturity level (TRL8) by the implementation in a real environment. To this end, 12 complementary partners with broad experience across the whole FOW value chain will join forces in a multi-disciplinary consortium. In addition, International stakeholders have already expressed their interest in the project, including Wind Europe, Ore Catapult, Carbon Trust & Sustainable Energy, making special emphasis in MHI Vestas Offshore Wind in order to support the demonstration project making available its largest capacity wind turbine up to 10MW.

Keywords: floating offshore wind,10mw wind turbine,demonstration,offshore wind technologies test site,lcoe optimisation,industrialisation,replicability,sea conditions,offshore wind farms,oandm,concrete
miRNA-activated Scaffold Technologies for Cartilage Regeneration (miRaColl)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Ireland
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-09-01
End date: 2017-02-28
Duration (months): 18.0
Total project cost (EUR): 149450.0
EU funding (EUR): 149450.0
Participants: 1
Project status: CLOSED

Adult articular cartilage has a limited capacity for repair so when damaged it can lead to joint degeneration and ultimately osteoarthritis. In our lab we have had significant success in enhancing tissue regeneration by functionalising collagen-based scaffolds for the delivery of therapeutic genes. In this project we propose to apply this concept for the delivery of microRNAs to promote enhanced cartilage repair.

Keywords: tissue engineering,regenerative medicine,cartilage repair strategies,mirna technologies
Digital Innovation Hubs: dynamic facilitation and thrust from regional innovation agencies (DIHnamic)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain
Call: Supporting experimentation in innovation agencies (H2020-INNOSUP-2018-06-two-stage, 2018)
Start date: 2019-09-01
End date: 2022-08-31
Duration (months): 36.0
Total project cost (EUR): 496250.0
EU funding (EUR): 496250.0
Participants: 1
Project status: CLOSED

ICE (formerly ADE) has been the innovation support agency for the SMEs in the region of Castilla y León (Spain) for more than 20 years. ICE has acted as the orchestrator of the Digital Innovation Hubs (DIHs) in Castilla y León, promoting the transfer of technology and new innovation practices and projects in the SMEs that will derive in the digitisation of the regional industry. The overall objective of the DIHnamic project is to verify, at a large-scale, new innovative facilitation services that have been already piloted with success, orchestrated by means of the dynamic facilitation and thrust of the Digital Innovation Hubs (DIHs) in the region of Castilla y León, and other DIHs across Europe, addressed at SMEs from Castilla y León, and its dissemination at the European level throughout innovation agencies. In this sense, DIHs will be promoted as the ideal one-stop shops for SMEs to facilitate access to innovation services. To that aim, DIHnamic establishes 3 specific objectives: O1. To desing and implement a cascade funding that will provide monetary support to digitalisation support measures aimed at regional SMEs (at least 50 SMEs) thanks to the Digital Innovation Hubs. O2. To explore other innovative facilitation mechanism throughout collaborative work with other agencies. O3. To show the adequateness of the RCT methodology to assess the effectiveness of innovative actions. The DIHnamic project is structured in three main pillars that will run for 36 months: I) mapping and specification of innovation in innovation agencies; II) randomization and intervention in the DIHs; and III) assessment of impact and effectiveness and framework for replication.

Keywords: innovative facilitation services,digital innovation hubs,randomized control trials,cascade funding,startups accelerator,mentoring
A cultural history of comparative art practices and receptions in Cold War Europe (1945-1991) (GYSIART)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-01
End date: 2021-01-31
Duration (months): 36.0
Total project cost (EUR): 244269.0
EU funding (EUR): 244269.0
Participants: 2
Project status: CLOSED

Cold War studies tend to emphasize dual narratives, mostly investigated as actions that are dictated from above by State policies or as cultural relations in an international context. Starting from my previous studies on bilateral art relations in the second half of 20th century, the project is intended as a comparative survey within a polycentric and inclusive European focus area, including the two German republics, Yugoslavia, the Soviet Union and Italy. The main study cases will be provided by multilateral art encounters and the involved locations and actors, analysed as individual and collective art practices. Unique Cold War art archives and collections at the Getty Research Institute and at the Wende Museum in Los Angeles will provide key resources. In order to assess the impact of the art practices on culture and society, I intend to investigate both their critical reception in the professional art world and their popular response through the commentaries left by exhibition visitors. A crucial question is whether the European dimension has ever been considered as a common ground - be it of political, social, artistic or speculative nature - for multilateral art practices within the divided continent. Particular attention will be paid to unmet expectations and missed connections among the interested art communities. By including current Member and Associate States and Third Countries, the research is meant to contribute to inter-European comprehension and integration, as an essential premise in order to “inform the reflection about present problems and help to find solutions for shaping Europe's future”, as stated in the Work programme 2016-2017 of Horizon 2020. The project is conceived as a multidisciplinary research which, through training and inter-sectoral mobility in Comparative Studies, History and Art History, will have a ground-breaking impact on my future career prospects in the academic and non-academic sectors as Comparative European Art Historian.

Keywords: exhibition history,visual imagology,cold war,cold war art archives,art practices,comparative european art history,multilateral relations,polycentrism,euro communism,yugo communism
Punishment as Communication: Transgressors’ Interpretation and Understanding of Punishment (PUNISH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2020-06-30
Duration (months): 12.0
Total project cost (EUR): 87403.2
EU funding (EUR): 87403.2
Participants: 1
Project status: CLOSED

Punishment is ubiquitous. We discipline children when they misbehave, and we demand even harsher sanctions for criminal offences. Punishment is thought to serve a communicative purpose: Through punishment, victims and third parties seek to send various “messages” to transgressors (e.g., condemning the wrongness of the act and imploring them to reform). But are these messages effectively delivered and understood by transgressors? And does the interpretation of a punitive message have the desired effects on the transgressor? To answer these questions, this research examines (a) the types of messages transgressors receive through punishment (why they think they are being punished), and (b) transgressors’ reactions to them (e.g., perceived fairness, experienced remorse). Further, it explores (c) the features of a punitive message that influences how the message is interpreted by transgressors. The research will be built on a theoretical framework that integrates knowledge from three distinct fields: legal philosophy, social psychology, and behavioural economics. The specific hypotheses deducted from this framework will be tested in controlled experimental lab studies as well as in a court setting. The insights from this research will be informative to all disciplines interested in criminal justice and punishment. First, this research will develop our theoretical understanding of punitive procedures and their effects. Second, it has important implications for how we should deliver punishment to enhance justice outcomes, whether in the context of formal legal proceedings or informal sanctions. The quality of the research will be strengthened by access to exceptional research facilities and expertise at the host university, and interdisciplinary collaboration with scholars both within the university and beyond. Further, the expertise and methodological training acquired through the fellowship will significantly develop the researcher’s capacities and profile.

Keywords: social psychology,justice,punishment
Interactive biomembranes for wound management – exploiting the unique wound healing and antimicrobial properties of human collagen VI (WOUNDCOM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2019-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

This project's objective is to develop a wound dressing product that will address the unmet needs of patients with chronic wounds. The prevalence of chronic wounds is increasing and results in a growing utilization of healthcare and financial resources. The available wound care options can manipulate one or multiple aspects of the wound environment, but cannot form antibacterial barriers and facilitate healing to a satisfactory level at the same time. Colzyx aims to address this challenge by developing an innovative wound dressing product that will make use of the newlydiscovered healing and antimicrobial properties of human collagen VI. It is first-in-class product which uses highly functional molecules from the human innate immune system in wound management. This novel technology combines these potent molecules with a biomembrane – established in wound management market. Together, they effectively enhance wound closure and fight bacterial infection simultaneously. This approach offers significant benefits to patients by reducing pain and discomfort, and accelerating recovery. It will also shorten hospitalisation time and decrease labour for healthcare professionals and the financial burden. Comparing to available wound dressings, Colzyx’s product is unique and will address a new market category of interactive biomembranes. The ultimate success will depend on the quality of confirmatory data and agreement with development partner to share the challenges of subsequent research and market introduction. Colzyx plans to take the product through the CE-mark registration study and reach the market through an agreement with a strong defined licence partner. The problem of pathogenic resistance to drugs is growing and highlighted by the national and international health organisations. This adds to the significance of the challenge posed by chronic wounds and ensures Colzyx in the endeavour of developing and bringing to the market its novel wound dressing.

Keywords: biomembranes,wound dressing,human collagen vi
Adapting protein fate for muscle function and fitness (PROTEOFIT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-12-01
End date: 2024-11-30
Duration (months): 60.0
Total project cost (EUR): 1746825.0
EU funding (EUR): 1746825.0
Participants: 1
Project status: SIGNED

Muscle function is essential for motion, exercise, and shivering, whereas physical inactivity is causally related to reduced metabolic fitness in animal models and humans. A critical requirement for muscle function is that proteins are properly produced and, if necessary, degraded to adapt the proteome to meet metabolic demands. However, there is a fundamental, open gap in understanding how challenges to muscle proteostasis are sensed and how protein fate is subsequently adapted to enhance muscle function in exercise or, conversely, how it is compromised in obesity. I hypothesize that protein fate is highly adaptive and can be fine-tuned to promote proteostasis, the integrity of muscle cells, and metabolic health. Identifying novel key regulators of these mechanisms in muscle may hold great therapeutic promise for targeting metabolic fitness to combat obesity and associated disorders. In this innovative project I want to define new mechanisms of muscle adaptation in humans and preclinical mouse models, with the ultimate goal of using this knowledge to improve muscle function and fitness in obesity. I will identify exercise- and obesity-specific substrates of the proteasome by ubiquitomics in human and mouse muscle and define how the ubiquitination and turnover of these proteins dictates muscle cell function. In a complementary approach, I will use novel loss- and gain-of-function mouse models allowing for precise muscle-specific manipulation of Nfe2l1, an adaptive regulator of proteasomal protein degradation, to define the biological and therapeutic significance of this pathway for muscle function in exercise and obesity. In summary, this novel work will provide a transformative molecular understanding of muscle adaption to metabolic challenges and provide insight into how this translates into metabolic fitness and the development of obesity and associated disorders in humans.

Keywords: muscle,exercise,obesity,metabolic adaptation,proteostasis,proteasome
Kidney Transplantation - Functional ImmunoGenomics (KiT-FIG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Chronic renal failure affects ~10% of the world population and can gradually lead to end-stage renal disease (ESRD) requiring kidney transplantation. Despite the huge progress of immunosuppressive treatments, the host immune response against the graft still leads to rejection in many cases, with an average graft half-life of 10 years. Triggers leading to graft rejection are still largely unknown and need to be studied beyond the well-recognized impact of HLA mismatches. I propose here to explore the effect of functional immunogenomic parameters beyond HLA mismatches (HLA alleles, HLA gene expression regulation, KIR...) on kidney transplantation outcomes (cellular and humoral rejections, tolerance). To achieve this present-day clinical challenge, I will combine innovative bioinformatics tools and modern genomics to perform cutting edge association studies: the Kidney Transplantation - Functional ImmunoGenomics (KiT-FIG) project. KiT-FIG ultimate goal is to provide new evidence to improve graft allocation and transplanted patients’ management. Objective A is to develop innovative methods of HLA statistical inference to gain precision and generate additional functional immunogenomic parameters. Objective B is to apply these novel methods to investigate the impact of immunogenetics on immunological outcomes related to kidney transplantation. This objective will rely on genetic association studies to unlock the major scientific challenge of large and unexplained variability observed in renal graft survival. KiT-FIG ambitions to develop new innovative bioinformatic and biostatistics tools to capture the complexity of HLA-related immune responses. These tools will be freely accessible to the community to expand immunogenetic studies of other diseases. The implementation of these tools in the context of kidney transplantation outcomes will increase the understanding of underlying immunological mechanisms and will contribute to improve graft survival and patient management.

Keywords: immunogenomics,bioinformatics,imputation,kidney transplantation
Resource wars in an unequal world: international law and beyond (REWA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2023-05-23
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

The growing demand for resource commodities, coupled with the climate crisis, have increased pressures on ecosystems and individuals who are already at the margins of society. Conflicts over natural resources and the environment are considered among the greatest challenges of the 21st-century. While the link between resource scarcity or wealth and armed violence is increasingly discussed by political scientists, there is still little understanding of how international law operates in this venue of global governance, where power imbalances shape relations among different actors (transnational corporations, governments, international institutions, and peoples). By conducting two case-studies, which focus on the problem of ‘conflict resources’ and the security impacts of climate change, this project will illuminate international law’s role in framing these types of conflicts and finding ways to tackle them, and the place of different actors within legal discourses. It will demonstrate how distributive concerns may be sidelined and inequalities perpetuated through legal/institutional arrangements. This project will open intellectual spaces to rethink common ‘solutions’ to the international legal order’s most pressing concerns: the ecological crisis, rising civil wars, and their interaction. It will initiate a more inclusive and much-needed debate about alternative understandings of international peace and security, which reflect the lived-experiences of peoples in the Global South. Through the integration of other disciplines into the study and critique of international law, this project presents the opportunity to open a new field of knowledge, which will spark the interest of different constituencies (e.g. legal, political, IR scholars), and aligns with the interdisciplinary character of research at the HO.

Keywords: international law,international peace and security,peacebuilding,climate change,laws of war