Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Empowering Research Talent: Building R&I Talent Ecosystems to Advance Careers in Health Innovation (BREATH)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Spain,Lithuania,Belgium
Call: Talent ecosystems for attractive early research careers – pilot (HORIZON-WIDERA-2024-ERA-02, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 2032085.0
EU funding (EUR): 1997010.0
Participants: 16
Project status: SIGNED

The BREATH project aims to build a well-structured and sustainable Talent Ecosystem in Health Innovation (HI) management in three key European regions—Catalonia, Flanders, and Lithuania—where talent managers from academic and non-academic institutions collaborate to drive institutional changes and implement initiatives that enhance researchers’ careers, talent retention and mobility. To achieve this, BREATH will first engage all relevant stakeholders to assess the current needs of the HI ecosystem, including labour market demands, skills gaps, and the identification of current and future career paths. The goal is to provide Early-Career Researchers (ECR) with tools and guidance specifically tailored for the HI field through the BREATH Experience. The objectives of this experience are twofold: (a) to deliver personalised training to ECR, achieved by collaboratively developing tailored career paths, pinpointing essential skills for each path, and addressing skill gaps with customised training modules; and (b) to provide individualised guidance through enhanced career support services at partner universities. A key output will be the creation of a Career Path Guidance Platform, which will serve as a centralised resource for ECRs to explore career paths, identify up-to-date skills in HI, and access tailored training opportunities. The project will pilot and evaluate these new career paths, training programs, and guidance services across the three regions. The findings will contribute to policy formulation aimed at improving research career management at national and European levels, focusing on attractive career opportunities and effective talent development strategies for researchers. In summary, the BREATH project aims to enhance the European research landscape, empowering ECRs and ensuring the research and innovation sectors are equipped with the talent needed to thrive in a competitive global market.

Keywords: health innovation researchers career path guidance skills training talent management talent ecosystem institutional changes research career development intersectoral mobility talent retention
Structural studies of the human mitochondrial RNA life cycle (MitoRNA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499754.0
EU funding (EUR): 1499754.0
Participants: 1
Project status: SIGNED

Mitochondria maintain an organellar genome that encodes for subunits of the respiratory chain. Its coordinated expression is essential for eukaryotic life, and defects in this process lead to severe disease in humans. Mitochondrial gene expression is carried out by unique dedicated molecular machineries, but the underlying molecular mechanisms remain poorly characterized. During my previous work as a PhD student and Project Leader, I provided the structural basis of human mitochondrial transcription. At the same time, structural insights on mitochondrial translation were reported. However, our understanding of mitochondrial gene expression remains limited due to two fundamental knowledge gaps. First, we lack a molecular understanding of the complex mitochondrial RNA life cycle that takes place in between transcription and translation. Second, we do not know how the different steps of mitochondrial gene expression are functionally coupled, as they are not separated by membranes. With MitoRNA, we propose to take the next big leap towards a mechanistic understanding of mitochondrial gene expression by addressing these blind spots. Using an innovative integrated structural biology approach, we will define the molecular basis of the human mitochondrial RNA life cycle and how it is embedded in the concert of mitochondrial gene expression. In particular, we will investigate the structural basis of various key steps of mitochondrial RNA metabolism in vitro and in situ, and dissect how they are coupled to each other. This ground-breaking work will open up the next frontier in mitochondrial biology by drawing a molecular picture of human mitochondrial RNA metabolism and providing insights into the functional organization of mitochondrial gene expression. In addition, it will also advance methods to study mitochondrial biology from the atomic to the organellar scale.

Keywords: mitochondria,cryo em,structural biology,gene expression rna
Innovative modelling and assessment capabilities through MaaS for Manufacturing Ecosystem resiliency (DMaaST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Spain,Germany,Portugal,Türkiye,Slovenia,Belgium,Lithuania,Denmark,Switzerland,France,Serbia
Call: Achieving resiliency in value networks through modelling and Manufacturing as a Service (Made in Europe Partnership) (RIA) (HORIZON-CL4-2023-TWIN-TRANSITION-01, 2023)
Start date: 2024-05-01
End date: 2028-04-30
Duration (months): 48.0
Total project cost (EUR): 5862752.5
EU funding (EUR): 5862752.5
Participants: 14
Project status: SIGNED

DMaaST aims to enhance the manufacturing ecosystem's resiliency and capability of self-adaptation in response to external events. It is achieved through a Smart Manufacturing Platform comprising 4 layers: The data layer establishes a foundation for mapping manufacturing ecosystem information using ontologies and decentralized knowledge graphs, ensuring a trusted cross-organization real-time data integration. Next, a layer with a two-level cognitive digital twin is created, with the low-level DT modelling two use cases' manufacturing services production line; and the high-level DT modelling the main stages of use-cases’ sectors value chains. The resulting DTs will use human expertise-knowledge, data-driven algorithms and physical modelling to provide a reliable and robust DT of the manufacturing ecosystem. The next layer employs the data and modelling layer's information to present a multi-objective distributed decision support system algorithm combining multi-objective techniques and the latest trends in Federated Deep Learning. This makes DTs actionable models and provides the necessary information to make optimal production decisions. The fourth layer focuses on presenting the information in a user-friendly manner with timely scoreboards. Additionally, a dedicated module will assess the production's circularity and sustainability and considering products traceability through the EU-DPP. Therefore, the sustainability and remanufacturing opportunities of the production process will be improved. The project ensures scalability, providing information for replicating and trying new manufacturing processes thanks to the manufacturing services digital warehouse while assessing risks and opportunities for improvement. DMaaST innovations enable the manufacturing ecosystem to adopt the Manufacturing as a Service concept by smoothly evolving all the technologies from a TRL3 to a consolidated TRL6 in 2 use cases in key sectors, aerospace and electronics.

Keywords: cognitive digital twins multi objective distributed decision support system sustainability circulariy traceability decentralised knowledge graphs ontologies data interoperability
DEmystifying Targets in Endothelial Cells for anti-Tumor Immunity improVEments (DETECTIVE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: SIGNED

Despite significant medical advancements, cancer remains a major cause of mortality worldwide, and several cancer types still lack efficient therapy, in part due to resistance to traditional immunotherapy (IT). Endothelial cells (ECs) present an important yet overlooked modulator of tumor immunity, possessing an immunosuppressive nature, and proposed to contribute to IT resistance. Studies of the host lab indeed identified immunomodulatory features in EC subsets (coined IMECs). My central hypothesis is that targeting immunosuppressive (IMMUSUP) genes in tumor ECs may promote anti-tumor immune reaction to overcome resistance and improve the efficacy of traditional IT. The aim of this work is to identify novel, IMMUSUP genes expressed by tumor ECs and assess the potential of targeting these genes in vivo to promote anti-tumor immune response. I will explore in particular “mystery genes” (with poor functional annotation, ca 1/3 of the mammalian coding genome and an unexplored resource of potential targets) to maximize the identification of novel IMMUSUP genes beyond the currently used targets in traditional IT. Thus, I will (i) identify and prioritize EC IMMUSUP genes using artificial intelligence/machine learning approaches and (ii) in silico bioinformatics coupled to a mystery-genome wide siRNA screen to reveal IMMUSUP activity; (iii) confirm IMMUSUP targets via lipid nanoparticle-based siRNA delivery to generate EC-specific knockdown mice in models of lung, esophageal, and liver cancer; and (iv) determine the Mode of Action of the most promising targets using multidisciplinary approaches. My work will yield insights about previously unknown drug targets in tumor ECs, potentially paving the way for development of alternative IT with enhanced efficacy. My prior experience in immunology and bioinformatics combined with the host lab's expertise in EC (dys)function and single cell -'omics' technologies will ensure high quality execution of this project.

Keywords: alternative immunotherapy immunology tumor microenvironment immunomodulatory endothelial cells artificial intelligence machine learning single cell rna sequencing
Technological Research On Propulsion by HYdrogen (TROPHY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Aviation
Action type: Innovation actions
Partnership: CLEAN-AVIATION (JU-JTI)
Countries involved: France,Italy,Belgium,Germany,Poland,Türkiye
Call: Hydrogen fuel system for direct burn engine ground test execution and flight test preparation (HORIZON-JU-Clean-Aviation-2023-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 29012882.57
EU funding (EUR): 20599024.07
Participants: 21
Project status: CLOSED

The TROPHY project, which stands for “Technological Research On Propulsion by HYdrogen”, aimed at supporting the Clean Aviation HYDEA funded project (HYdrogen DEmonstrator for Aviation), which proposes a technology maturation plan to develop an H2C (Hydrogen Combustion) propulsion system compatible with an Entry Into Service of a zero CO2 low-emission aircraft in 2035. TROPHY supported design activities related to the development of an H2 engine fuel system as well as the investigation of integration aspects between engine and aircraft. Decision was made by the consortium to close TROPHY grant agreement as it turned out that key objectives as initially envisaged were no longer relevant.

Keywords: hydrogen green deal,sustainable aviation,aeroengines,direct burn,gas turbine,engine fuel system,demonstrator,equipment delivery,flight test preparation
Social cognition in 22qll.2 schizophrenia mouse model – role of mPFC dysfunction and oxytocin (LgDel-mPFC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: CLOSED

Schizophrenia is associated with impairment of social cognition and social function. Medial prefrontal cortex (mPFC) is crucial for processing of social cues and regulation of social behaviour. Altered connectivity within mPFC in schizophrenia patients compared to healthy controls could explain patients’ poorer ability to differentiate between individuals and impairment to emotion recognition. 22q11.2 deletion syndrome is one of the largest know genetic risk factors for developing schizophrenia and is associated with impairments to social recognition and emotion processing. However, the changes to mPFC neurocircuitry in 22q.11.2 causing the social cognition deficits remain poorly understood. Oxytocin (OXT) is pivotal to social recognition and social function. Inactivation of mPFC OXT receptors impairs social recognition in mice comparable to social cognition deficits in schizophrenia. The 22q11.2 deletion mouse model (LgDel) displays impairments to social memory and emotion recognition and mice display altered mPFC neuronal activity patterns during cognitive tests and brain OXT levels are lower in LgDel compared to wild type mice. These findings suggest that social cognitive deficits in schizophrenia could be caused by disruption to mPFC neurocircuitry, possibly mediated by altered OXT availability or by OXT modulation of dopamine within mPFC. Using a combination of cutting edge electrophysiological recordings and measurement of OXT and dopamine real-time dynamics during a battery of non-social and social cognitive tests, I aim to deliver detailed information about neuronal activity and synchrony throughout the mPFC in during social cognition tests in WT and LgDel mice. This will provide insight into the micro-circuitry underlying changes to neurofunction and cognition in schizophrenia cause impairments, which could aid the improvement of treatment of social cognition deficits in Schizophrenia.

Keywords: mpfc schizophrenia 22q11 2 oxytocin
Vividye Removable Print Evaluation (Vividye)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Sweden
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-06-01
End date: 2023-01-31
Duration (months): 8.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Vividye offers a removable printing innovation that enables reuse of textiles. The technology is integratable in existing industrial settings and is aiming to facilitate the reuse of workwear. With cutting edge technology from Chalmers University of Technology in Gothenburg, Sweden, we develop a product in close collaboration with industrial partners. The technology is strictly speaking two parted, with printing easily scalable but with the unique removal functionalization more difficult to visualize and frame. Within the frame of this project we want to evaluate the business opportunity of the removal step - while integrating a good strategy for protection of the intellectual property and continuously integrating sustainability in our business model. This programme would enable us to reach the market faster and offering a removable print sooner. We want to offer a circular business model in the strive for a more sustainable future and we believe this programme could give us the right tools to achieve these goals.

Keywords: circular textile business model,removable textile print,evaluation of processing step,integration of ip strategy and environmental impact
Manufacturing process for bio-based fibre-reinforced composite parts for structural applications (BioStruct)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Photonics (co-programmed)
Countries involved: Austria,Poland,Spain,Italy,France,Cyprus
Call: High-precision OR complex product manufacturing – potentially including the use of photonics (Made in Europe and Photonics Partnerships) (IA) (HORIZON-CL4-2023-TWIN-TRANSITION-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 6793843.54
EU funding (EUR): 5476221.52
Participants: 10
Project status: SIGNED

Currently, the use of bio-composites is limited to less critical applications that do not have significant requirements in terms of mechanical performance. However, the use of synthetic composites made from carbon or glass fibre has several difficulties in terms recycling and in terms of dependence on third countries. About 98% of these synthetic composites still end up in landfills and about 80% of the raw materials are currently manufactured outside of Europe. To improve this situation, the project addresses the challenges of using bio-composites for structural parts and aims to increase the range of applications in which bio-composites can be used. This will be achieved by developing an accurate draping process to control fibre orientation, by creating material models that capture the natural variability of the material and by integrating nano-structured, bio-based sensors for load monitoring. Through the increased accuracy and additional control loops in the manufacturing process the consortium expects to achieve predictable properties and constant quality. Within the project use cases from wind energy and boat-building will be investigated, aiming at the manufacturing of a full size rotor blade and a ship hull to demonstrate the technical feasibility and achieving TRL7 for the manufacturing technologies. In addition to the end users, the consortium consists of partners from automation, machine building, measurement technology, material manufacturing and simulation software to cover all aspects of the developments. Based on the predicted growth of the bio-composites market, which is expected to increase by a factor of 2.5 by 2030, the consortium expects a market potential of about 100M€ by 2030.

Keywords: bio composites,draping,material models
Shifting to zero-emission logistics with right-sized, mission-focused, N1 eLCVs (Shift2Zero)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Innovation actions
Partnership: 2ZERO (co-programmed)
Countries involved: Spain,Belgium,Austria,Italy,Norway,Greece,Poland,France,Germany,Netherlands,Czechia
Call: New designs, shapes, functionalities of Light Commercial Vehicles (2ZERO Partnership) (HORIZON-CL5-2024-D5-01, 2024)
Start date: 2025-01-01
End date: 2028-06-30
Duration (months): 42.0
Total project cost (EUR): 12339067.25
EU funding (EUR): 9999992.0
Participants: 31
Project status: SIGNED

Current market dynamics in EU reveal a gap between supply - existing N1 vehicles, and demand - evolving needs of urban logistics and climate targets. In 2023, 1.2M new LCV registrations were diesel-powered, and only 108,200 battery-electric. Last-mile logistics, the least efficient and most complex part of the supply chain, presents significant opportunities for improvements at vehicle and operations levels. Dynamic requirements and increasing environmental impact require innovative solutions from the automotive industry, both from high volume OEMs and new entrants. S2Z aims to capitalize on the benefits of both vehicle platforms in the N1 segment - represented by IVECO’s eDaily multi-purpose platform, and Alke’s ATX design-for-purpose platform, ultimately contributing to “Shifting to zero-emission logistics through right-sized, mission-focused, N1 e-LCVs”. To achieve this vision, S2Z proposes a 4-step user- and mission-centric design approach placing end-users and their needs at the core of all project activities. To this end, S2Z involves 5 LSPs & mobility operators as partners: Gruber, DHL, Diakinisis, Clem, DPD. As a result, we will co-develop and shape at least 6 novel N1 concepts with enhanced and safe functionalities leading to tighter market fit, particularly in the segments of e-commerce, returns and cold deliveries. Innovative concepts, from modular cargo bodies to vehicle control strategies with optimized tyres & brakes, as well as dual transport of people & freight, will be physically prototyped and tested in real-life operations in 6 pilot sites (BE, GR, IT, 2 x NO, PL). S2Z brings a multidisciplinar consortium of 30 partners from 10 countries to cover the complete automotive and logistics value chains, complemented by policymakers to effectively ensure our route to market: overcoming barriers for the adoption of S2Z eLCVs, reducing operational costs and environmental impact in scalable urban & sub-urban operations.

Keywords: elcvs,n1,logistics,right sized,physical internet