Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
BUMBLEbees nutritional uPgrades for toLerance Against plant protectioN products (BUMBLE-PLAN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 209483.28
EU funding (EUR): 209483.28
Participants: 1
Project status: SIGNED

Pollination is a vital ecosystemic service for human well-being and subsistence. Pollinators including bumblebees (bees from the Bombus genus) are a keystone for the correct development of this service. Despite their importance, pollinators' population and diversity are extremely threatened by factors linked with human impacts like Plant Protection Products (PPPs, like pesticides) and land use. Because of this, both private and public efforts and funding are aimed at guaranteeing pollinators' biodiversity and health status. Project BUMBLE-PLAN set its basis on this premise but simultaneously included a new and holistic perspective on the role of the gut microbiome on the health status (pathogens control and detoxification pathways) of bees. The main objective of this project is to improve the resilience of managed bumblebees by developing a nutritional supplement capable of providing resistance to PPP commonly used in the agricultural sector and indirectly conferring resistance to various pathogenic organisms that may affect them in synergy. To assess this objective BUMBLE-PLAN is proposed with cutting-edge methodologies like BIOLOG, NGS (WGS) and gene expression qPCR. The results obtained are expected to improve our understanding of the ability of bacteria to metabolize PPP's and clean the environment. As a result, a new sustainable and ecological tool would be acquired to improve pollinators' health and the ecosystem. From these contributions provided by the BUMBLE-PLAN project, it is expected that new research questions will be generated (mainly around the One-Health concept) that will be addressed through the application for future funding, encouraging further internal research. For the correct implementation of the BUMBLE-PLAN project this proposal combines the expertise in pollinator´s behaviour and pathology of the fellow and the infrastructure and wide knowledge - experience of Prof Diana Di Goia and her teamwork at the University of Bologna

Keywords: microbiome,bumblebees,agrochemicals,pesticide degradation,microbial phenotyping
Photonic System Engineering with Microcombs (MicrocombSys)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden,France,Belgium,Denmark,Germany,Switzerland,Spain
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 3029622.17
EU funding (EUR): 2788624.8
Participants: 16
Project status: SIGNED

Optical frequency combs are fascinating photonic devices for realizing modern applications that rely on precision frequency synthesis and metrology. Today, microcombs offer the prospect of attaining, in a single chip-scale form-factor, an optical frequency comb with outstanding performance in terms of line spacing and bandwidth coverage. With microcombs, some proof of principle, lab-based system-level demonstrations have been realized, but these make use of large bulk components and instrumentation that prevent the large-scale deployment of this technology in mass-market applications. The overall ambition of this doctoral network is to provide the scientific and training necessary to bridge the gap between proof-of-principle applications and deployment of this disruptive technology. The network brings together experts from academia and industrial leaders in microresonator frequency combs, heterogeneous integration, packaging technology, and nonlinear physics, while covering a wealth of emerging applications: from quantum information processing to biophotonics. The collaborative science is embedded in a meaningful, comprehensive and tailored-made training program that covers crucial aspects in diversity, digital science, entrepreneurship and innovation. This network will catalyze the career of 12 doctoral candidates who will pave the way for novel scientific endeavors and deploy this technology in mass-market applications, from datacenter interconnects to lidar in self-driving cars.

Keywords: frequency comb silicon photonics
Dynamic Electron Imaging with Phase Retrieval (DECIPHER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Netherlands,Switzerland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2024-11-30
Duration (months): 30.0
Total project cost (EUR): 215937.6
EU funding (EUR): 215937.6
Participants: 3
Project status: CLOSED

Quantifying the multiscale functionality of light-triggered hierarchically-structured assemblies represents a challenge in materials science underpinning the design of efficient next-generation optoelectronics, photovoltaics, and energy storage nanodevices. Critical to this challenge is the availability of new metrology and inspection tools which allow to probe the out-of-equilibrium dynamics of these materials, while interacting with light pulses, with quantitative contrast to all its components. DECIPHER proposes to combine phase retrieval image reconstruction methods with the advances in pulsed electron source technology, to build a break-through microscope capable of directly visualizing the nanoscale dynamics of functionalized materials with fs-ps temporal resolution and Å-nm spatial resolution. The proposal has three main objectives: (i) Construct a next-generation ultrafast electron diffraction imaging system. (ii) Implement cutting-edge phase retrieval methods to enable full-field quantitative imaging across length scales with sensitivity to heavy and light elements. (iii) Leverage these new methods to directly visualize light-activated functioning NP supracrystals, with unique sensitivity to their quantitative chemical/elemental composition and, simultaneously, to their 2D/3D topography. This approach will enable the study of nanoscale dynamical behavior with unprecedented detail and provide vital feedback toward the design of energy-efficient, high-performance devices.

Keywords: ultrafast coherent diffractive imaging,functionalized nanoparticles
Accelerating the iMpact of microsurgEry by upscaling production of thE world’s first microsurgical roboT: MUSA (MEETMUSA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-01-01
End date: 2024-04-30
Duration (months): 28.0
Total project cost (EUR): 2637708.75
EU funding (EUR): 1814022.0
Participants: 1
Project status: CLOSED

The revolution in microsurgery is here. Microsure, a highly innovative Dutch medical device company is introducing MUSA, the world’s first clinically available CE-certified microsurgical robot. We will maximize microsurgical performance by offering superhuman precision and comfort through robotic assistance in pursuit of excellence for both patients and health providers. The MUSA robot is highly efficient thereby reducing costs and improving access to microsurgical procedures. With the great unmet need in microsurgery, we are convinced that the timing for market introduction of MUSA is right and the field is ready to accept and implement MUSA for better patient outcomes. In this project, we will tackle the remaining bottlenecks for succesful outroll of the product including upscaling and optimizing manufacturability, to allow for rapid market uptake of MUSA after the project. MicroSure will introduce MUSA in all parts of Europe before 2029, reaching major societal and economic impact.

Keywords: microsurgery,microsurgical robot,anastomosis,open surgery
Accelerated X-in-the-loop Environment for Small Satellite Testing (AXESS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-09-01
End date: 2026-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The New Space is expected to become the biggest industry in human history. In 2023, the global space economy was valued at about $500B. The number of space probes is bound to thrive, yet their growth is unsustainable: developing spacecraft autonomy is paramount to remove the costs and limits of human-in-the-loop operation activities. However, developing resilient autonomous technologies requires extensive empirical testing in representative environmental conditions, and access-to-space costs are still prohibitive. AXESS offers a web-based Testing-as-a-Service platform dedicated to spacecraft systems and technologies. Erected over the EXTREMA Simulation Hub, AXESS provides an integrated testing environment in which high-fidelity, X-in-the-loop experiments of space systems are performed under a state-of-the-art accelerated framework. Moreover, AXESS allows adopters to embrace a more flexible and agile CI/CD philosophy, enabling automated testing of space software, firmware, and IP core designs on modules and testbenches that are representative of real space technologies and hardware. Access to the platform will be granted through a web-based user interface, from which it will be possible to configure the automatic and manual test routines, monitor and control the ongoing testing activities in real-time, and collect simulation logs and metrics. AXESS allows the users to carry out data-driven system design, debugging, and fine-tuning through all the phases of the system development lifecycle. The project follows a suitably devised pathway to cover technical validation activities and assessment of exploitation opportunities. AXESS has raised the interest of the leading sectoral players and space agencies, as witnessed by the letters of support attached.
Spatial Metabolic Regulation in Kidney Repair (SPARK)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Chronic kidney disease (CKD) is a global health concern, and the limited treatment options for end-stage kidney disease have remained unchanged for decades. Concurrent insults to the kidney can exacerbate disease progression, but the underlying potential to have kidney repair after such injury remains poorly understood. The tricarboxylic acid (TCA) cycle, a fundamental metabolic pathway, plays a vital role in energy production and biomolecule synthesis. Recent research by my group has revealed that failed repair and subsequent fibrosis in kidney epithelial cells are linked to anaplerotic failure in the TCA cycle, resulting in the inability to maintain sufficient levels of TCA intermediates. These metabolites regulate chromatin remodeling and cell signaling pathways, influencing cell fate decisions. SPARK aims to investigate the impact of perturbed cell metabolism and metabolic crosstalk within kidney microenvironments on cell fate decisions during injury and repair. The project will map the metabolic, proteomic, and transcriptomic interactome at an unprecedented resolution, focusing on the kidney tissue microenvironment. By integrating spatial multi-omics data, exometabolite interactome analysis, and human kidney biopsies, actionable targets will be identified. In vivo studies using reporter mice and ex vivo preserved human kidneys will validate the metabolic effects of the selected targets. This research will provide insights into how the metabolic interactome governs repair through epigenetic modulations in the kidney and establish a paradigm for studying tissue homeostasis in various contexts.

Keywords: kidney disease,cell metabolism,cell fate decision,spatial metabolomics
Green Laser-Assisted Surface Structuring (GLASS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Greece,France,Belgium
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2023-05-01
End date: 2025-12-31
Duration (months): 32.0
Total project cost (EUR): 2498945.0
EU funding (EUR): 2498945.0
Participants: 3
Project status: SIGNED

Biomimetic (BIOM), spin-off the Foundation for Research and Technology-Hellas (GR), was founded in 2020 to lead the exploitation of the results coming from a long R&D pathway on developing laser strategies for producing bionic surfaces (e.g. LiNaBioFluid and Biocombs4Nanofibers FET projects). One of these investigations led to GLASS, a novel, cost-effective laser process, capable to imprint biomimetic antireflective (AR) nanostructures on glass. GLASS provides remarkable AR properties, using a single-step and environmentally friendly manufacturing process, contrary to the most used AR coating techniques in industry that involve the use of chemicals and multiple steps. Considering the huge commercial applications that this unique laser strategy can have (e.g. displays, special optics, digital cameras, automotive, telecommunication, solar systems), with this project BIOM will funnel efforts to address the major challenge of GLASS related to the mechanical durability of laser treated glass. Ultimate aim is the use of GLASS-produced AR glass for small-scale commercial applications, placing emphasis on consumer electronics displays and specialized optics markets. For this purpose, BIOM is partnering with Corning Inc (CORN), currently the leading glass manufacturer for consumer electronics, to work together on optimizing the GLASS process to meet the mechanical durability specifications of the two respective markets, while at the same time will co-develop with LASEA, a recognized laser systems manufacturer, an automated GLASS laser system. These technical improvements will be validated by CORN undertaking the role of customer, while BIOM with the support of FORTH PRAXI NETWORK, a highly specialized company in technology

Keywords: optical engineering,photonics,lasers biomimetics nano technology business development
Designing the Irresistible Circular Society (DESIRE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Other missions
Destination: Other missions
Action type: Coordination and support actions
Countries involved: Denmark,Slovenia,Latvia,Italy,Netherlands,United Kingdom
Call: Support the deployment of lighthouse demonstrators for the New European Bauhaus initiative in the context of Horizon Europe missions (HORIZON-MISS-2021-NEB-01, 2021)
Start date: 2022-10-01
End date: 2024-11-30
Duration (months): 26.0
Total project cost (EUR): 4754000.0
EU funding (EUR): 4754000.0
Participants: 24
Project status: CLOSED

Designing an Irresistible Circular Society (DESIRE) aims to create an alternative way forward for the built environment supporting the EU mission of ‘100 climate-neutral and smart cities’. Against seemingly insurmountable challenges of climate change, biodiversity loss, and resource depletion we need to rethink our approach to finding solutions. Departing from architecture, design and art we will create an open learning environment with principles, methods and guidelines to support us in designing an irresistible circular society. We will present a DESIRE lighthouse demonstrator, built on insights and learnings from on-site demonstration activities taking place on sites in Denmark, Italy, Latvia, Slovenia, and The Netherlands, encompassing various themes and scales. By this, we will set the foundation for a school of thought and practice, and establish a scaling framework for widespread learning across the EU utilizing digital infrastructure, stakeholder involvement and empowerment across a partner community of European cities, youth organisations, NGOs, academia etc. Our territorial sites form the core of DESIRE. Three themes have informed our choice of sites and partners. ‘Creating social and inclusive housing’ addresses the need for inclusive processes, ‘the power of we’, in circular transformation of social housing. ‘Reconciling cities with nature’ is about designing livable habitats and functional ecosystems from a multispecies perspective while rebalancing ‘land use’ to accommodate resource generation and biodiversity. ‘Transforming through symbiotic relationships’ focuses on how to optimize use of materials flow when rethinking urban landscapes in cities. In depts on-site demonstration activities will unfold in three Danish sites (an old asphalt factory in Herlev, a social housing neighbourhood in Taastrup, and an urban transformation project in Kalundborg) and contribute to similar demonstration activities in Amsterdam, Ljubljana, Milan, Riga and Turin.

Keywords: movement,prototyping,democratic engagement and civic participation,renovation,transformation,regenerative,aesthetics,art,co creation
Chronic Deep-Brain Micro-Endoscopy in Behaving Animal Models: Advancing Holographic Endoscopes Along the Path to Global Availability. (NEUROGATE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Czechia,Belgium
Call: Transition Open 2024 (HORIZON-EIC-2024-TRANSITION-01, 2024)
Start date: 2025-05-01
End date: 2028-04-30
Duration (months): 36.0
Total project cost (EUR): 2925550.72
EU funding (EUR): 2498226.97
Participants: 4
Project status: SIGNED

Utilising a hair-thin multimode optical fibre, the holographic endoscope allows minimally invasive, high-resolution in-vivo imaging at subcellular levels across any brain structure. The NEUROGATE project will significantly enhance the potential of this breakthrough technology for biomedical imaging by commercialising critical innovations in holographic endoscopy, developed through the prior ERC-PoC projects WOKEGATE and StrokeGATE. The innovations include bending-resilient fibres and brain interfaces, enabling chronic studies, minimising tissue damage and providing flexibility in reconnecting with the region of interest. They make holographic endoscopy the breakthrough technology which enables chronic in-vivo imaging of neuronal signalling and structural connectivity in deep brain regions of freely moving animal models, overcoming several limitations of current technologies. NEUROGATE brings together three academic partners and a commercial venture to validate the system under real-world conditions and achieve TRL6, spinning out the new technology across biomedical research sector, where its potential market exceeds €850 million. This novel tool aims to transform neuroscience by enabling chronic in-vivo monitoring of vitally important brain processes at the microscopic level in both healthy and diseased states, with broad applications in research and medicine.

Keywords: endoscopy,optical fibre,digital holography,intravital microscopy,deep brain imaging,minimally invasive imaging,biomedicine
A new look at the solar coronal heating problem (ACDCSUN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: United Kingdom
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 2483461.0
EU funding (EUR): 2483461.0
Participants: 1
Project status: SIGNED

The proposed project aims to transformatively advance our understanding of the enigmatic phenomenon of solar coronal heating. The ground-breaking nature of the proposed research is the anticipated revolutionary change of our understanding of basic physical mechanisms for the formation and evolution of the solar and stellar coronae. The key novel elements of the study are fresh and original hypotheses and methodologies. We hypothesise that a significant fraction of the energy released short-durational bursts of magnetic reconnection goes to oblique fast magnetoacoustic waves. This effect mitigates shortcomings of the previous approaches, modifying the observed statistics of solar flares, and spreading the heated region across the magnetic field. We shall design a novel technique for the diagnostics of the coronal heating function by coronal compressive waves, based on the recently established effect of coronal thermal misbalance, apply it to constraining parameters of various heating mechanisms and establish those most consistent with observations. We shall reveal the mechanism for the energy transfer from the low atmosphere to the corona by studying the phenomenon of decayless kink oscillations of coronal loops and establish its role in the coronal energy balance. This timely research will be based on the use of high-precision observational data obtained with observational tools of the new generation, including instruments onboard the Solar Orbiter space mission, and state-of-the-art theoretical modelling. A significant component of this activity is the effective dissemination of the results to the research community and general public. The research programme is organised in three work-packages addressing different aspects of the research, but well connected with each other by the common methodology and instrumentation. The project team will consist of Professor V Nakariakov as PI, 2 post-doctoral researchers, 2 PhD students, and Warwick Physics Outreach Officer.

Keywords: magnetohydrodynamic waves,solar corona