Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
INTEgrated opeRation PLAnning tool towards the Pan-European Network (INTERPLAN)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Italy,Cyprus,Poland
Call: Tools and technologies for coordination and integration of the European energy system (H2020-LCE-2017-SGS, 2017)
Start date: 2017-11-01
End date: 2021-01-31
Duration (months): 39.0
Total project cost (EUR): 2964362.5
EU funding (EUR): 2964362.5
Participants: 6
Project status: CLOSED

The European Union (EU) energy security policy faces significant challenges, as we move towards a pan–European network based on the wide diversity of energy systems among EU members. In such a context, novel solutions are needed to support the future operation of the EU electricity system in order to increase security of supply also accounting for the increasing contribution of renewable energy sources. The goal of INTERPLAN project is to provide an INTEgrated opeRation PLANning tool towards the pan-European network, to support the EU in reaching the expected low-carbon targets, while maintaining network security. A methodology for proper representation of a “clustered” model of the pan-European network will be provided, with the aim to generate grid equivalents as a growing library able to cover all relevant system connectivity possibilities occurring in the real grid, by addressing operational issues at all network levels (transmission, distribution and TSOs-DSOs interfaces). In this perspective, the chosen top-down approach will actually lead to an "integrated" tool, both in terms of voltage levels, going from high voltage down to low voltage up to end user, and in terms of building a bridge between static, long-term planning and considering operational issues by introducing controllers in the operation planning. Proper cluster and interface controllers will be developed to intervene in presence of criticalities, by exploiting the flexibility potentials throughout the grid. The achievement of the project goal will be ensured by the subdivision of the needed steps in seven Work Packages, each of them, with a specific measurable objective. The project is in line with the Work Programme, in ensuring more flexibility and active involvement of all stakeholders, and a close coordination of TSOs and DSOs. Moreover, its versatility in the concept of grid equivalents, will allow an accurate analysis of the complex network, by considering local active elements in the grid.

Keywords: integrated operation planning,pan european network,interconnected eu grids,tso dso interfaces,grid clustering,grid equivalents library,cluster and interface controllers,flexibility sources
AGE-RELATED CHANGES IN HEMATOPOIESIS (ARCH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Austria,Spain,Italy,Israel,Italy,Germany,Greece,Belgium,France,France,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-06-01
End date: 2023-11-30
Duration (months): 54.0
Total project cost (EUR): 3969936.36
EU funding (EUR): 3969936.36
Participants: 19
Project status: SIGNED

ARCH is a network of highly qualified experts in experimental hematology created to decipher the causal relationship between the physiological changes in the hematopoietic system during lifespan and the parallel occurrence of specific age-related hematological diseases (pediatric, adult, elderly), with the aim to develop novel targeted therapeutic treatments. ARCH research will integrate the results from complementary model systems (cell lines, mouse models, cells from leukemia patients) and it will deploy a large panel of cutting-edge technologies, such as single cells genomics, epigenomics, genome editing and organoid cultures, in a multi-faceted effort. The ARCH ambitious goal requires scientific and financial resources beyond the capability of a single group. To reach this goal, the ARCH network brings together 15 beneficiaries (12 academic, 2 SMEs and 1 private research institute) and 5 Partner organisations (3 academic, 1 SME and 1 patients’ association). Two European Consortia are present through their italian nodes. ARCH will recruit 15 ESRs that will be all enrolled in PhD programmes. Besides research laboratory work, the ARCH training programme includes scientific, technical and transferable skills courses that will provide ESRs with a solid scientific culture and with awareness of responsible research and innovation issues. This broad portfolio will enable ESRs to become leading academic, clinic or industrial players in the field. The unique combination of scientific excellence, quality of the educational programme and experience in translating basic research into exploitable results will provide ARCH with the real possibility of positively contributing to the enhancement of European competitiveness in the development of innovative, targeted drugs/treatments for hematological diseases, which currently represent a serious socio-economical problem for the European health care system.

Keywords: hematopoiesis,cell differentiation,leukemia,cell signalling,genomics,bioinformatics,target identification,drugs,treatments for hematological diseases
Transitional Care Innovation in Senior Citizens (TRANS-SENIOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Italy,Israel,Belgium,Switzerland,Poland,Belgium,Netherlands
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2018-10-01
End date: 2023-09-30
Duration (months): 60.0
Total project cost (EUR): 3209021.8
EU funding (EUR): 3209021.8
Participants: 8
Project status: SIGNED

The TRANS-SENIOR EJD-network builds capacity for tackling a major challenge facing European long-term care systems: the need to improve care for an increasing number of care-dependent senior citizens. Its specific focus is on avoiding care transitions (hospitalisations, nursing home admissions etc.) that are not necessary and on optimising care transitions that are really needed. This is important as research and practice show that unnecessary or poorly managed care transitions in senior citizens lead to negative health and well-being consequences and high costs for society. RESEARCH objectives of TRANS-SENIOR are generate evidence on 1) when and where avoiding care transitions is possible, 2) the benefits of innovative transitional care models, and 3) methods for involving senior citizens and informal caregivers, and sustainable implementation of new care models. TRANS-SENIOR PRODUCTS are: tools to support senior citizens and informal care givers in decision making and preparing for transitions; guidance for professionals' triage, citizen empowerment and decision making; protocols for the effective delivery of transitional care models; a toolbox for the implementation of these care models; an assessment tool for evaluating the financing of long-term care; policy briefs to inform future long-term care policy and processes; and a training syllabus to inform future doctoral training in Europe. TRANS-SENIOR will train HEALTH CARE INNOVATORS. Our multi-disciplinary, multi-sectoral team will give the ESRs the knowledge, research expertise and transferable skills needed to lead improvements in real-world care settings. TRANS-SENIOR's health care innovators will be able to operate on the cutting edges of practice, science, policy and innovation.

Keywords: transitional care,public involvement,implementation research
T cell-driven inflammatory mechanisms promote recovery after acute brain injury (RecoverInFlame)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-11-01
End date: 2024-04-30
Duration (months): 66.0
Total project cost (EUR): 1487500.0
EU funding (EUR): 1487500.0
Participants: 1
Project status: SIGNED

The overall goal of this project is to investigate T cells as “Trojan horses” to improve recovery from brain injuries – we will gain novel insights on how T cells promote neurologic recovery by modulating the cerebral micromilieu and how these pathomechanisms can be therapeutically targeted. Inflammation is a common response to acute brain injuries, which are a leading cause of morbidity and mortality. I have recently identified continuous cerebral T cell recruitment as a hallmark of a long-lasting and profound neuroinflammation after acute brain injury. While a detrimental effect of T cells in the acute phase has been well documented, the pathophysiological consequences and therapeutic potential of T cell-driven chronic inflammation for recovery after brain injury are unknown. Interestingly, my recent findings indicate that T cell fate is orchestrated in the gut via modulation of commensal bacteria and that T cells potently promote stroke recovery. Building up on these recent findings, I hypothesize that T cells contribute substantially to the recovery after brain injury by inflammation-driven remodeling. Using several innovative methodologies applied for the first time to recovery after brain injury, we will firstly investigate the contribution of T cells on cortical connectivity, spine plasticity and mechanisms of glial responses. Next, we will analyze the contribution of the gut microbiota to modulate the chronic neuroinflammatory response via a pro-regenerative polarization of T helper cells. Finally, we will test the generalizability and translational robustness of our findings in models of various acute brain injuries and common comorbidities. Results from this project are likely to open up a new research field on T cell-driven neurologic recovery after brain injury, thereby revolutionizing our pathomechanistic understanding and provide novel therapeutic strategies for one of the most pressing medical problems.

Keywords: stroke,traumatic brain injury,neuroinflammation,t cells,microbiota,gut brain axis,microglia
ENIneering MAterial properties with advanced laser direct writing (ENIGMA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-01-01
End date: 2024-12-31
Duration (months): 72.0
Total project cost (EUR): 2499957.0
EU funding (EUR): 2499957.0
Participants: 1
Project status: SIGNED

Ultrafast laser material processing is approaching its limits in terms of ability to produce innovative materials with compositional and structural consistency. The main idea of this project is to remove barriers to product development and go beyond state-of-the-art by applying tailored and few-cycle laser pulses (FCLPs) for engineering of materials. In this project I will investigate the interaction between intense ultra-short light pulses and matter at or below the wavelength scale reaching states of matter found only deep planetary conditions.A key goal of the project is to exploit these extreme conditions for synthesising unique material phases with on-demand optical and electronic properties, and progress photonic devices with utilizing FCLP advantages: control over the bond scissoring density; efficient and highly localized energy deposition; seeding of self-organized nanostructures; manipulation of spatio-temporal coupling. Currently, a key limitation is plasma scattering that diminishes the performance of engineered materials. The question I will address is whether control of ultra-short pulses can lead to ways around this limitation. The control of self-organization process will revolutionize the field of data storage by achieving record high 100 TB/cm3 densities, high writing speed and practically unlimited lifetime. I will radically improve the performance of printed flat optics with perfected nanostructures engineered from nano- to macro-scale and capable of replacing conventional optics significantly advancing photonic devices used in high-resolution microscopy, consumer electronics, and high-power laser applications. I envisage obtaining exotic material phases such as metallic phases of silicon and tailored metallic nanoparticles in silicate glass. Hence this project will push the frontiers of laser material processing to unprecedented precision and will develop novel family of devices that will feed into the future of optics, electronics and computing

Keywords: data storage,laser material processing
Antiresonant Hollow Optical Fibres for a Quantum Leap in Data and Optical Power Transmission (LightPipe)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-07-01
End date: 2022-06-30
Duration (months): 72.0
Total project cost (EUR): 2749639.0
EU funding (EUR): 2749639.0
Participants: 1
Project status: CLOSED

Fibre optics has revolutionised telecommunications, enabled the widespread diffusion of the internet and profoundly impacted industrial manufacturing, metrology, medical endoscopy and structural sensing, to name but a few. In many applications however, fibres are now being operated very close to fundamental physical limits of the glass that forms their core, and this is already providing hard limits, for example, to the maximum data capacity or optical intensity that can be transmitted through them. A transformative new technological step is required to help increasing the information capacity and power delivery capability of optical fibres to keep up with the 1.5dB/year growth in global data traffic and with the 2dB/year raise in laser output power. Air guiding hollow core fibres can provide a natural solution, but the state of the art technology suffers from conceptual physical limitations that bound their minimum loss, maximum information capacity, and transmitted optical power and energy. This proposal addresses these global challenges by developing the ‘ultimate’ hollow core optical fibre technology based on nested antiresonant nodeless fibres. Based on a recent discovery of the PI yet to find experimental demonstration, these fibres exploit antiresonances and multiple coherent reflections from the glass membranes to achieve, unlike any other known air-guiding optical waveguide, simultaneous minimisation of surface scattering and leakage loss. By targeting a 10 times increase in data capacity and power handling and a 5 times reduction in transmission loss as compared to state-of-the-art technology, all in an ultra-low nonlinearity fibre with excellent modal purity and spectral transparency, the outcomes of this project have the potential to revolutionise telecommunications 45 years after the development of ultra-low loss glass optical fibres and to produce a step-change in many industrial and scientific high power laser delivery applications.

Keywords: fiber optics,fiber design and fabrication,microstructured optical fibers,ultralow loss optical fibers,radiation hard fibers,laser delivery,high capacity data transmission
Quality of Service and prioritisation for emergency services in the LTE RAN stack (Q4HEALTH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Spain,Ireland,France
Call: Integrating experiments and facilities in FIRE+ (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2018-02-28
Duration (months): 26.0
Total project cost (EUR): 855037.0
EU funding (EUR): 728176.0
Participants: 3
Project status: CLOSED

Q4HEALTH project is an innovation action focused on the optimization of real time video for emergency services over LTE. The project is implemented as a set of experiments conducted over the FIRE platforms PerformLTE and OpenAirInterface. The motivation is to study video performance in scenarios with wearable live video for first responders, improving its response on LTE-A with a particular innovation focus on 3GPP release 12. To achieve this goal six different experiments will be performed focused on resolving a set of six challenges identified as well as addressing a range of KPIs Q4HEALTH faces different challenges, the inability of applications to negotiate a QoS agreement with the network, the delays introduced on live video, the appropriate scheduling algorithms on the access nodes, the service availability on indoor scenarios and the communication between geographically correlated entities. These challenges will be approached from different perspectives, the applications that will be extended to provide information regarding the type of traffic as well as their traffic requirements to the EPC and the scheduler in the RAN; the radio access where different scheduling strategies will be explored for emergency video; and the core network where mechanism to perform QoS reservation, techniques for seamless mobility between heterogeneous access technologies and SDN techniques to improve communication will be studied. Q4HEALTH has defined 20 KPIs and these will be formulated at the start as a baseline and at the end of the project we will measure the KPIs on an integrated optimized experiment in order to validate the project success. Q4HEALTH will participate in the EIT KIC as well as FIRE and 5GPPP events in order to disseminate our results in to the wider innovation ecosystem. All the project results and extensions will be showcased to maximize the exposures to other companies that might also exploit the outcomes of the project.

Keywords: emergency services,video
The AA2-Ratio: A Novel Diagnostic Biomarker for Primary Aldosteronism (PANOSTICS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Austria
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-04-01
End date: 2015-08-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

“PANOSTICS” comprises the validation and clinical implementation of a versatile and cost effective diagnostic blood test for the detection of primary aldosteronism (PA) among hypertensive patients. The Aldosterone-to-Angiotensin II-Ratio (AA2-Ratio) is a mass spectrometry based diagnostic biomarker for PA. We are planning to sell this diagnostic blood test to clinical institutions in a fee-for-service business model. Our vision is to build up a European network of qualified fee-for-service laboratories focused on hypertension-associated biomarkers. The market entry for the AA2-Ratio is planned via a subsidiary laboratory in Germany. Full commercialization of the AA2-Ratio shall be achieved by implementation into standard clinical practice for the classification and treatment of resistant hypertension. Hypertension has been clearly shown to be the most important cause of morbidity and mortality worldwide, representing a severe challenge for future healthcare systems. Up to 11,9 million people in Europe are referred to be resistant hypertensive, meaning that they cannot be cured by standard treatments. PA is a certain form of resistant hypertension that can be easily cured by appropriate second-line drug treatments or surgical procedures, if detected. Recommendations by clinical societies suggest extensive screening efforts to facilitate an early detection of PA among resistant hypertensive patients. However, actual clinical practice in Europe does not follow these guidelines due to the lack of appropriate and cost effective screening procedures. If PA remains undiagnosed, it caused severe hypertension frequently resulting in cardiovascular complications including heart attacks and strokes. The AA2-Ratio is a diagnostic biomarker for PA, that is superior to state-of-the-art assays and allows for a highly specific and cost effective diagnosis of PA among hypertensive patients.

Keywords: biomarker,hypertension,aldosterone,adenoma
European Researcher's Night in France (STORIES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: France,France,France,France,France,France,France,France,France,France,France,France
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-05-01
End date: 2019-11-30
Duration (months): 19.0
Total project cost (EUR): 1156916.25
EU funding (EUR): 445786.0
Participants: 13
Project status: CLOSED

We are proposing ERNs in 12 French cities for 2018 and in 13 for 2019. For 12 years, our consortium has organized successful national events, improving year after year the quality of the events, and the strength of the national coordination. Since the beginning, we have worked on the essence of scientific engagement: a successful, direct encounter between researchers and the public. The strategy is to spark the creativity of both researchers and the public via the proposition of a single general topic ("1001 Stories" for 2018, "Join in the Investigations" for 2019), and a large palette of engaging formats for the ensuing dialogues. Certain of these formats are common to the 12 towns, such as "Dialogues in the Dark", "Speed-searching", "Participatory Experiments". Scenography and artistic interventions will ensure a specific atmosphere, in line with the chosen topics: the dream-like quality of tales in 2018, the exciting thrill of investigation in 2019. In each of the 12 cities, between 1000 and 5000 people will attend the Night. More than 1200 researchers will be mobilized every year, reaching a total audience of more than 73,000 persons. The time spent by each visitor at the Night event as measured in previous years, 2.5 h., is high and we aim to increase it. An EU Corner café in each venue will ensure informal exchanges involving foreign researchers. Our proposal focuses on the training of researchers in the "art of the encounter" relying on a science communication training scheme developed by several partners in the framework of a French national project. Lastly, we plan to renew the "Great Participatory Experiment" in 2019. In each city, the public will contribute to a national participatory scientific experiment chosen in 2018 after a challenge involving all our research institutions. Formal partnerships have been established with the Ministries of Culture and of Research. This will ensure further national visibility.

Keywords: researchers,publics,meetings,dialogue,entertainment,france,event,european,participatory,together,atmosphere,experiment,experience,stories,investigations