Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Decoding the Combinatorial Epigenetic Information of the Mammalian Genome with Engineered DNA Duplex Readers (COMBICODE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2022-11-01
End date: 2024-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

In mammalian genomes, epigenetic modifications of the nucleobase cytosine occur in both strands of the DNA duplex in the sequence “CpG”, and they are central regulators of gene expression as well as important cancer biomarkers. However, current analytical techniques cannot reveal the combination in that these modifications occur in the two strands of a DNA duplex. The resulting inability to create genomic maps of these “CpG duplex modifcations” represents a major roadblock for future developments in epigenetics research and cancer diagnosis. We have engineered the first affinity enrichment probes for selectively analysing novel CpG duplex modifications, and integrated them into user-friendly and cost-effective kits for genomic mapping. In this project, we will develop and commercialize two kits for mapping of the most important novel CpG duplex modification consisting of 5-methylcytosine and 5-hydroxymethylcytosine for the epigenetics research and the liquid biopsy markets. This will provide decisive new impulses for epigenetics research as well as for cancer biomarker discovery and liquid biopsy, both large and rapidly growing markets.
The Transmission and Transformation of Texts in the Tarim Basin: a corpus approach (4TB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-03-01
End date: 2027-02-28
Duration (months): 24.0
Total project cost (EUR): 183600.96
EU funding (EUR): 183600.96
Participants: 1
Project status: SIGNED

The "Transmission and Transformation of Texts in the Tarim Basin: a corpus approach" project (4TB) is designed to contribute to the study of three prominent languages of the pre-Islamic Tarim Basin (in today’s Xinjiang Uygur Autonomous Region in the People’s Republic of China): Tocharian A, Old Uyghur, and Sanskrit. The innovation part of this contribution assumes creating a comprehensive parallel text corpus of Buddhist texts in the said languages, an open-access digital tool for linguistic and philological study. The research part assumes analyzing details and searching for patterns of transmission and transformation of those Buddhist texts, from Sanskrit to Tocharian A, from Tocharian A to Old Uyghur. This is going to be achieved by answering the following research questions: 1) What are the linguistic patterns of transmission and transformation of the discussed texts? 2) How were the discussed texts transmitted and transformed from the philological point of view? The results of my action will substantially facilitate cross-linguistic studies for scholars of three language groups. Also, they will have an interdisciplinary impact, bringing a large amount of textual information to non-linguist researchers, e.g., scholars of Buddhism and historians. Moreover, my action has a potential for further research, as it can later include other adjacent languages. The host institution will be University of Vienna. My supervisor will be Hannes Fellner, one of the key developers of the CEToM project (the Tocharian A and B text corpus) and the lead of the Tarim Brahmi project. His experience in Digital Humanities and the Tocharian studies will be extremely helpful for my research.

Keywords: digital humanities tarim basin studies
Network of National Contact Points for Cluster 6: Food, Bioeconomy, Natural Resources, Agriculture and Environment (CARE4BIO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Greece,Germany,Italy,Iceland,Belgium,Poland,Estonia,Austria,Sweden,Cyprus,Türkiye,Spain,Luxembourg,Portugal,Lithuania,Slovakia,Netherlands,Hungary,Albania,Tunisia,France,Romania,United Kingdom,Czechia,Malta
Call: Mobilising the network of national contact points in Cluster 6 (HORIZON-CL6-2021-GOVERNANCE-01, 2021)
Start date: 2022-06-01
End date: 2027-12-31
Duration (months): 67.0
Total project cost (EUR): 3400577.0
EU funding (EUR): 3400577.0
Participants: 26
Project status: SIGNED

CARE4BIO serves the needs for transnational cooperation between NCPs for Cluster 6 as well as for cross-cluster cooperation within Pillar 2, but also with other programme parts such as Widening Participation. We comprise a well-balanced network of 26 partners, including partners from the EU-13 and Associated Countries, combing all levels of relevant experience and expertise. Many of us fulfil multiple roles, for instance also working in NCP_WIDERA.NET, NCP Academy or EEN, different clusters and pillars, or appointed as programme coordinators. We are well set-up to deliver on our objectives, namely to (1) harmonise NCP services and increase their quality via transnational cooperation, (2) lower entry barriers for applicants, especially in less active member states and raise the quality of submitted proposals, (3) inform the European R&D community about cross-cutting synergies throughout Horizon Europe. To achieve this, we will cooperate with other (NCP) networks such as the ones mentioned above, to share knowledge and best practices, maximise efforts on informing NCPs, applicants and stakeholders, thereby raising the quality of proposals, breaking down silos, and encouraging trans-cluster collaboration. We will cooperate with the European Commission to assist in delivering upon political objectives such as the EU Green Deal, guiding applicants on policies, and providing feedback from our work as NCPs. We also offer concrete services for applicants, e.g., by organising yearly brokerage events to aid applicants in forming their own cooperation networks, and by supporting other matchmaking efforts. Our services will include training, learning resources, best practice manuals, policy briefings, and more. While our services will be available to whoever needs them, our focus is on NCPs and applicants from widening countries. Ultimately, our goal is to raise the general standard of support for potential applicants of Horizon Europe, contributing to increasing the quality

Keywords: national contact points,cluster 6,support services,networking services,capacity building
FEED your mind: Investigating the nature, ontogeny and evolution of cognitive processes underlying food behaviors, to pave a way toward efficient interventions promoting healthy eating in early life (F.E.E.D. your mind)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2025-05-31
Duration (months): 32.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

The rise of food-related health disorders calls for action. Food behaviors take shape early in life and track well into adulthood. Thus, efficient evidence-based interventions promoting healthy food practices in early life are key to tackling these challenges. The aim of the project is to shed light on the cognitive processes underlying food learning in infancy and provide empirical bases to design such interventions. The project adopts a novel perspective on food learning. Current research has overlooked that our modern food environment strongly differs from the environment in which our ancestors lived. In fact, in most cultures today, decisions about food are made during a trip to the grocery store, where we might ask ourselves: Are these canned tomatoes healthy? but certainly not: Are they edible or toxic?. As a result, scholars missed that a critical step in learning what to eat over the course of ontogeny, is determining which entities in the world are wholesome foods and which ones are harmful items to eschew. The project will fill this research gap using robust methods from neuroscience and psychology. First, WP1 will investigate the ontogeny and neuro-cognitive bases of the capacity to recognize food objects, testing whether this capacity emerges when infants transition to solid food, guiding their attention to food-relevant inputs, such as social information about edibility. Second, WP2 will examine the social component of food learning processes, once infants are able to recognize food objects, testing whether infants show a negativity bias when learning about food from others, giving more weight to negative than to positive information. Finally, building on WP1 and WP2 results, WP3 will investigate the longitudinal relationship between the processes underlying food recognition and learning in infancy and food behaviors later in childhood, paving a way towards designing efficient evidence-based interventions promoting healthy eating in early life.

Keywords: food cognition infancy social learning food behaviors conceptual development
Analytical testing of per- and polyfluorinated alkylated substances (PFAS) and their transformation products in electrical and electronic waste (E-PFAStest)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium,Germany,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 216240.0
EU funding (EUR): 216240.0
Participants: 3
Project status: SIGNED

Phones, tablets, and flat screens have ever-shorter innovation cycles and become swiftly obsolete, thus, electrical and electronic waste (e-waste) is currently the fastest-growing solid waste stream worldwide. Hence, e-waste is associated with numerous pressing challenges e.g., the release of pollutants like per- and polyfluoroalkyl substances (PFAS) and their transformation products (TPs). Given the growing concern over PFAS, also known as "forever chemicals" due to their high persistence in the environment, this research addresses critical questions about the contribution of e-waste toward the PFAS pollution. The goal of E-PFAStest is the development of analytical methods based on non-target screening (NTS) for comprehensively analysing e-waste samples for PFAS and their TPs. The E-PFAStest project has three parts: 1) Development of NTS analytical methods for the determination of PFAS in e-waste samples; 2) Development of testing procedures to simulate the formation of TPs from PFAS in e-waste samples; and 3) Analysis of PFAS and their TPs in environmental samples in the vicinity of e-waste facilities. As such, E-PFAStest will be the first study to comprehensively assess the PFAS contamination originating from e-waste as it identifies parent PFAS and TPs in e-waste and in the surrounding environment of e-waste facilities. In E-PFAStest, I will combine my skills in NTS of PFAS and method development at the interface materials-environment with the host lab’s analytical equipment and expertise, multi-disciplinary research, and network. Further, two secondments are foreseen, that will ensure the implementation of the electrochemistry approach for the simulation of TPs and the sampling in and around e-waste facilities. Thus, E-PFAStest will ensure my development as an independent researcher to establish my own research group on the topic of analytical development for emerging contaminants at the interface materials-environment.

Keywords: lc hrms,non target screening,pfas,e waste,transformation products tps
Silicon opto-electro-mechanics for bridging the gap between photonics and microwaves (SPRING)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2491486.0
EU funding (EUR): 2491486.0
Participants: 1
Project status: SIGNED

Conversion between electrical and optical signals enabled the use of near-infrared (near-IR) photons for high data rate transmission through optical fibre networks. Likewise, coherent conversion between microwave and optical photons stands as a promising solution to transfer quantum states between remote quantum processors, thus enabling the development of large-scale quantum networks. However, the vast frequency difference between microwave (GHz) and near-IR (200 THz) optical photons hampers direct coherent conversion. This limitation could be circumvented by phonon-mediated transduction, which is a coherent two-step process, comprising electromechanical and optomechanical conversions. On-chip microwave-optical conversion mediated by GHz phonons has the potential to be extremely efficient due to the large optomechanical response of common materials, and the similar wavelength of GHz phonons and near-IR photons. Yet, it is an open challenge to achieve efficient electromechanical and optomechanical conversion simultaneously in a single integrated circuit. State-of-the-art demonstrations show that surface acoustic waves (SAWs) allow efficient electromechanical conversion, while cavity optomechanics utilize tightly confined optical and mechanical modes to yield strong optomechanical coupling. However, combining these two approaches is still considered challenging, if not impossible. The SPRING project will overcome these limitations by developing a fundamentally new optomechanical coupling approach to bridge SAW electromechanics and cavity optomechanics. The original idea is to use subwavelength nanostructuration of silicon cavities to couple tightly confined optical modes and SAWs. The SPRING strategy will be used to demonstrate coherent microwave-optical conversion of single photons and quantum state transfer between superconducting qubits, monolithically integrated in a silicon chip, opening a new path for applications in communications, sensing and computing.

Keywords: silicon photonics,optomechanics
Morphing tubular structures for adaptive biomedical devices (Stripe-o-Morph)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-10-01
End date: 2024-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Morphing tubular structures are extensively used in interventional medical devices (e.g., stents). Current solutions lack adaptability to complex geometries and to patient-specific needs. Stripe-oMorph proposes the use of devices with superior morphing capabilities, bio-inspired by motile microorganisms, previously investigated in the ERC AdG “MicroMotility”, and based on the concept of morphingby-sliding of parallel strips.
Black Hole Horizons in Quantum Gravity (BHHQG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1497050.0
EU funding (EUR): 1497050.0
Participants: 1
Project status: SIGNED

The project "Black Hole Horizons in Quantum Gravity" aims for an in-depth investigation of black holes and the information paradox in the context of quantum gravity. Due to the recent breakthroughs in astronomy, these exotic objects have moved from the purely theoretical realm to being abundant in our physical universe. Surprisingly, our theoretical understanding of them is insufficient to even in principle understand their horizons and what happens behind them. Our approach to tackle these questions is to combine a lower-dimensional approach with holography as a guide. Within this framework, substantial breakthroughs were made in the Sachdev-Ye-Kitaev models, and their low-energy gravitational description in terms of Jackiw-Teitelboim gravity. This model is exactly solvable to a large degree, and many important lessons on black hole physics and quantum gravity can be studied quantitatively and exactly. Our goals within this project span across two lines. Firstly, we will apply quantum gravitational results on the Jackiw-Teitelboim gravity model to address aspects of the black hole information puzzle in a quantitative way and probe the deep questions on black hole horizons largely building on our detailed knowledge of this model. In particular, we will calculate correlation functions of local infalling bulk observables, and assess the effect of quantum gravitational corrections to evaporation. Secondly, it is vital to investigate the universality of the set of techniques and methods we use in Jackiw-Teitelboim gravity. We will do this by pursuing several roads simultaneously (dilaton gravity models, 2d string theory, the original Sachdev-Ye-Kitaev model, supersymmetric models and 3d pure gravity). Armed with these results, we will extrapolate to higher dimension and in particular to our physical universe making contact with the first objective.

Keywords: black hole physics,holography,quantum gravity,string theory
Textile fibre recycling from mixed streams of PESCO textiles (PESCO-UP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Processes4Planet (co-programmed)
Countries involved: Finland,Estonia,Slovenia,Latvia,Netherlands,Belgium,Germany,Italy,France,Spain,Sweden
Call: Circular economy in process industries: Upcycling large volumes of secondary resources (Processes4Planet partnership) (RIA) (HORIZON-CL4-2023-TWIN-TRANSITION-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 12500469.42
EU funding (EUR): 10775305.8
Participants: 23
Project status: SIGNED

Europe has an extensive textile waste problem - annually 7 –7.5 million tons of textile waste is generated, but only about 30 - 35 % of the generated waste is collected separately and less than 1% is recycled into new clothing. Collection of textile waste will become mandatory in EU member states by 2025. Most of the textile are cotton, polyester, or their blends. Considerable amounts of CO/PES blends are disposed every year due to the technical challenge and/or economic viability of recycling. The objective of PESCO-UP is to develop a sustainable and economically and technologically viable process of the mixed CO/PES textile waste to be upcycled into cotton originated and polyester products. The processes should enable for production of new products without quality restriction and of products with identical properties and performances as those produced using primary resources. The main tools to achieve this are the development of automated identification and sorting methods for textiles, Digital Product Passport with a marketplace-style dataspace for sharing data describing material streams to support matching of supply and demand of textile materials, and the process development of purification, separation technologies as well as the technologies that utilize the separated cotton and PES fractions for the valuable products. PESCO-UP will ensure that sustainable fiber-to-fiber recycling becomes a reality in Europe. This will turn a societal waste problem into a business opportunity for European SMEs and bring the textile industry back to Europe. At the same time dependency on oil and cotton based raw materials will decrease, which will mean reduction in CO2 emission and reduced water consumption. The use of developed digital methods and digital product passport can be widened in other industrial sectors to solve their recycling and sustainability issues.

Keywords: textile recycling,circularity,blend textile,cotton,polyester,pes,digital product passport,chemical recycling,lca,life cycle assessment,value chain,business potential,business case