Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SC-square - Satisfiability Checking and Symbolic Computation: uniting two communities to solve real problems (SC-square)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Austria,Germany,Germany,Italy,Germany,Italy,France,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: FET Exchange Coordination and Support Activities 2015 (H2020-FETOPEN-2015-CSA, 2015)
Start date: 2016-07-01
End date: 2018-08-31
Duration (months): 26.0
Total project cost (EUR): 499603.75
EU funding (EUR): 499603.75
Participants: 11
Project status: CLOSED

The use of advanced methods to solve practical and industrially relevant problems by computers has a long history. Whereas Symbolic Computation is concerned with the algorithmic determination of exact solutions to complex mathematical problems, more recent developments in the area of Satisfiability Checking tackle similar problems but with different algorithmic and technological solutions. Though both communities have made remarkable progress in the last decades, they still need to be strengthened to tackle practical problems of rapidly increasing size and complexity. Their separate tools (computer algebra systems and SMT solvers) are urgently needed to examine prevailing problems with a direct effect to our society. For example, Satisfiability Checking is an essential backend for assuring the security and the safety of computer systems. In various scientific areas, Symbolic Computation enables dealing with large mathematical problems out of reach of pencil and paper developments. Currently the two communities are largely disjoint and unaware of the achievements of each other, despite strong reasons for them to discuss and collaborate, as they share many central interests. However, researchers from these two communities rarely interact, and also their tools lack common, mutual interfaces for unifiying their strengths. Bridges between the communities in the form of common platforms and roadmaps are necessary to initiate an exchange, and to support and to direct their interaction. These are the main objectives of this CSA. We will initiate a wide range of activities to bring the two communities together, identify common challenges, offer global events and bilateral visits, propose standards, and so on. We believe that these activities will initiate cross-fertilisation of both fields and bring mutual improvements. Combining the knowledge, experience and the technologies in these communities will enable the development of radically improved software tools

Keywords: satisfiability checking,symbolic computation,algebra,arithmetic,polynomials,algorithms,software technology,smt solvers,computer algebra systems
Reconstructing normative economics on a foundation of mutual advantage (NormativeEconomics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2016-01-01
End date: 2021-06-30
Duration (months): 66.0
Total project cost (EUR): 1172374.0
EU funding (EUR): 993616.44
Participants: 2
Project status: CLOSED

Economics has traditionally assumed that individuals seek to satisfy coherent and asocial preferences, and has used the satisfaction of those preferences as a normative criterion. This ‘neoclassical’ approach has supported a view of the market as an institution in which privately-motivated individual actions tend to produce socially beneficial consequences. These ideas have been called into question by recent developments in behavioural economics, which point to the cognitive limitations of economic agents, the instability of preferences, and the existence of pro-social motivations. A common inference is that traditional presumptions in favour of the market and against paternalism are invalidated. I aim to develop an approach to normative economics, and a corresponding understanding of the role of markets, which do not require neoclassical rationality assumptions but may still support those presumptions. My approach is innovative in two ways. First, the criterion for normative analysis is opportunity, not preference satisfaction. Even if individuals lack coherent preferences, opportunities for mutually advantageous transactions can be defined in a normatively significant way, and competitive markets can be shown to be effective in providing such opportunities. Second, using a new version of the theory of ‘team reasoning’, the relationship between parties to a market transaction can be construed in terms of a joint intention to achieve mutual benefit. This motivation can support practices of trust and cooperation without disabling market incentives. Using the methods of theoretical and experimental economics and analytical philosophy, I will formalise and integrate these ideas and extend them to provide a new understanding of the role of government in the economy. This work will include analyses of distributional fairness, market ethics, and of the role of regulation in maintaining competitive markets in the face of consumers’ cognitive limitations.

Keywords: normative economics,behavioural economics,opportunity,team reasoning,mutual advantage
Providing Key Account Management services for the SME Instrument beneficiaries and enhancing innovation management capacity services to Lithuanian SMEs in 2017-2018 (SME Coach LT 2017)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Lithuania,Lithuania,Lithuania
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 73017.5
EU funding (EUR): 73017.5
Participants: 4
Project status: CLOSED

The overall aim of SME Coach LT 2017 is to increase effectiveness and efficiency of investment in R&D and Innovation by enhancing innovation management capacity of Lithuanian SMEs -beneficiaries of the new dedicated SME instrument under Horizon 2020, and SMEs with significant innovation activities and a high potential for internationalization. Specifically, the project will support SMEs - beneficiaries of the SME instrument- in identifying project-specific barriers and weaknesses and gaps in their innovation capacities that hinder realization of growth opportunities, and pointing to suitable coaches to address the identified weaknesses. The Key Account Manager will support SMEs SME Instrument beneficiaries in identifying critical issues and gaps with regards to their innovation idea and guide them to relevant lead coach who will support the company throughout their innovation journey. The Key account Manager will use a holistic and dynamic business innovation model, supported by Business Innovation Roadmap Tool, available under Creative Commons License from smE-MPOWER network. The second specific objective is supporting SMEs with significant innovation activities and a high potential internationalization in enhancing their innovation management capacities. When supporting companies having innovation and internationalization potential, but not part of SME instrument, we will use IMP3rove Academy’s diagnostic tool which measures the performance of the company’s innovation management system. However taking into account the SME context, we intend to use action- based (and case-driven) learning approach to addressing identified gaps in the innovation system. smE-MPOWER tools can support the coaching process.

Keywords: innovation capacity
Glycomics of Winery Antimicrobial Yeast (GLYCO-WAY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2021-02-15
End date: 2024-02-14
Duration (months): 36.0
Total project cost (EUR): 263732.16
EU funding (EUR): 263732.16
Participants: 2
Project status: CLOSED

The recent emergence and spread of anti-microbial resistance (AMR) generates serious concerns. AMR related infections result in 25K deaths and €1.5 billion healthcare costs in the EU annually. A promising strategy involves strengthening the intestinal barrier and modulating gut microbiota using prebiotics. Cell walls polysaccharides, mainly from S. cerevisiae, showed great potential for mitigating antibiotic burden. At present however, our understanding of the mechanism of action underlying these biological effects is significantly lacking, mostly due a rudimentary characterization which hinders identification of key molecules and delays the production of effective feed supplements. This primitive characterization is due to the heterogeneous nature of polysaccharides, which have challenged researchers for years. Recent technological breakthroughs now provide analytical toolsets that enable a more comprehensive understanding of the fine structure of large polysaccharides. Based on the hypothesis that other yeast strains will have the same positive effects than S. cerevisiae, this project will employ cutting edge Glycomics approaches to unravel mannan and glucan structures from the most widely used non-saccharomyces yeast strains in the wine industry, and subsequently evaluate their effectiveness, isolated and in combination, to reveal key mechanistic insights. The project will be carried out in The Barile Lab at the UC-Davis (USA), an internationally recognized center with experience in Glycomics applied to Food Science, and in the CSIC (Spain), one of the most productive research institution in EU. The knowledge gained by the applicant in Glycomics for Food Science will be transferred to the EU by implementing a European Reference Center in this field at CSIC (Madrid, Spain). The objectives proposed, will enable the applicant to become an expert in glycomics and strengthen his professional independence. The proposed research is in line with the H2020 objectives.

Keywords: prebiotic,antibiotics,polysaccharides,cell walls,yeast,glycomics
Lung-like gas supply for hydrogen oxidation reaction in fuel cell anode (HydrogenLung)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-02-01
End date: 2024-04-03
Duration (months): 24.0
Total project cost (EUR): 202680.96
EU funding (EUR): 202680.96
Participants: 1
Project status: SIGNED

In researches about hydrogen oxidation reaction (HOR) at the anode of a fuel cell, most researchers concentrate on the intrinsic activity and stability of catalysts, while few researches study the gas diffusion effect in depth, which is however the rate-determine step for most HOR. Enlightened by the efficient lungs’ supply of oxygen to human with multistage bronchi and pulmonary alveoli, we plan to improve the hydrogen gas diffusion for HOR by constructing multistage superaerophilic gas channels (MSGC) in the catalyst layer (CL). Traditionally, to build gas channels in CL, people modify powder catalysts with aerophilic binder, which however cause aggregation and therefore hindered the transfer of electron and mass. Besides, part of the randomly made gas channels are closed that cannot transfer hydrogen actually. Thus, there are two challenges in MSGC construction: a solid and strong hierarchical micro-nano skeleton, that won’t aggregate, to support catalyst and channels, and a method to control the direction of the channels. Herein, we propose tungsten carbide nanoarrays (WC NA) as the skeleton for Pt catalyst and invent a vacuum-control method based on superwetting technology to direct the gas channels. Although WC nanoparticles have been proved promising as the substrate of Pt for HOR, WC NA has never been tried. Based on the novel structure, we will study the relationship between structure, gas diffusion, and HOR efficiency in depth. Targeting at the rate-determine step of HOR, we’re expecting a theoretical breakthrough in HOR, which will offer an alternative approach for making hydrogen anode in fuel cell industry.

Keywords: electrochemistry,heterogeneous catalysis
Optical nanoscopy at 1 nm resolution: far-field fluorescence control at cryogenic temperatures (OptnanoATcryo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2020-06-30
Duration (months): 60.0
Total project cost (EUR): 1911792.5
EU funding (EUR): 1911792.5
Participants: 1
Project status: CLOSED

Optical nanoscopy is a powerful technique used in biology to study subcellular structures and function via specifically targeted fluorescent labels. Localization microscopy in particular offers a much better resolution (~10-50 nm) than conventional microscopy (~250 nm) while being relatively undemanding on the experimental setup and the subsequent image analysis. The next revolution in imaging to 1 nm isotropic resolution in 3D must realize a big increase in the number of collected photons from single fluorescent emitters as well as in the labelling density. Only then can subcellular structures be imaged at the molecular level to study the molecular machinery of the cell. Notably observations of DNA conformation in 3D at such resolutions would be spectacular and enable investigation of biophysical models ranging from chromosomal DNA packaging to gene regulation. I propose a new imaging technique based on fluorescence control at cryogenic temperatures in combination with novel data driven super-resolution reconstruction schemes employing prior knowledge that promises this unprecedented optical far-field resolution. I introduce a twofold technical leap by i) much higher photon counts due to negligible photobleaching at cryogenic temperatures while maintaining the sparsity required for single emitter localization and ii) relaxing the required labelling density using a priori information and the averaging of many identical entities. Orientational blinking ensures single emitter localization via a combination of polarization sensitive excitation, detection and stimulated depletion and triplet state shelving. Biophysical models of cell structures and data driven priors mean that fewer samples are needed to fully describe a structure. In a larger perspective, the outcome of this research will enable the combination of structural cryo-electron microscopy imaging at subnanometer resolutions with functional fluorescent imaging at the nanometer scale.

Keywords: incomplete data reconstruction,prior knowledge driven image processing,localization precision,3d isotropic resolution,polarization control,cryo fluorescence,super resolution microscopy
Integrating Epidemiology and Experimental Biology to Improve Risk Assessment of Exposure to Mixtures of Endocrine Disruptive Compounds (EDC-MixRisk)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Greece,Sweden,Sweden,Sweden,Sweden,Sweden,Sweden,Finland,France,United States
Call: Understanding health, ageing and disease: determinants, risk factors and pathways (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-05-01
End date: 2019-04-30
Duration (months): 48.0
Total project cost (EUR): 6223330.0
EU funding (EUR): 6223330.0
Participants: 14
Project status: CLOSED

A large body of evidence supports associations between exposure to anthropogenic chemicals and endocrine disruptive effects, leading to disorders in humans and wildlife. Based on the scientific documentation it is beyond doubt that endocrine disrupting chemicals (EDCs) are of concern and need to be handled according to the risks they pose, as single chemicals or as mixtures. To develop chemical risk assessment to respond to these concerns, there is an urgent need to improve our understanding of the mechanisms and health effects of EDCs, in particular in mixtures. This will require selection, refinement and development of tools for assessment of EDC mixtures to bring current risk assessment procedures to a level where they can support risk management. This project is designed to promote the use of safe chemicals for the next generation. EDC-MixRisk aims to meet the societal need for improved decision-making regarding human exposure risks to mixtures of EDCs. EDC-MixRisk will determine risks for multiple adverse health outcomes based on molecular mechanisms involved after early life exposure to EDC mixtures. The task is approached through interdisciplinary cooperation between experts in epidemiology, experimental toxicology and molecular biology, and risk assessment. The value of this combined research effort is: i) Identification of EDC mixtures that are associated with multiple adverse health outcomes in three health domains (growth and metabolism, neurodevelopment and sexual development) in epidemiology; ii) Identification of molecular mechanisms and pathways underlying the associations between exposure and adverse health outcomes by the use and development of state-of-the-art experimental models and iii) Development of a transparent and systematic framework in risk assessment for integrating epidemiological and experimental research to facilitate the assessment of risk and societal impact, thus promoting better risk management for EDCs and their mixtures.

Keywords: endocrine disruptive chemicals,mixtures,epidemiology,3r model systems,growth and metabolism,neuronal development,sexual development,risk assessment,societal impact
BactiLine at-line system for automatic monitoring of microbial bacteria in water (BactiLine)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Denmark
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The growing population is putting a strain on the world’s water resources while at the same time the ever-developing industrialization is causing increasing occurences of water-contamination, both in potable water sources and in wastewater, which is discharged into rivers and oceans. To deal with these issues of water contamination, Mycometer has developed an automatic early-warning solution, the BactiLine at-line system, which promptly detects elevated levels of bacteria in water systems and sends out a warning when bacteria presence is above tolerated limits. BactiLine can be implemented at main control points in the distribution system, sample the water quality at pre-determined intervals and report to a control database. The BactiLine system is based on the existing and patented Bactiquant®-water method, which measures the total bacteria presence in a water sample by use of a sensitive fluorescence technology For end-users the BactiLine solution presents the following benefits: i. Faster response time, as water is sampled several times a day and bacteria counts are reported within minutes of the sampling ii. Larger sample sizes, with bacteria concentrated through filtration, minimizes the risk of false positives. iii. Improved possibility for remote water quality monitoring through automated sampling from the water source iv. More resource-efficient sampling process with the elimination of manual work hours for lab technician v. The assay sensitivity can be adjusted in real time, allowing the technology to be used in a broad range of water types and applications With the BactiLine system, Mycometer will target utilities companies, wastewater treatment plants and industrial plants using large amounts of water for production processes, leading to a sales revenue of €7.2M, five years post project.

Keywords: water quality,bacterial monitoring,automated water sampling
How to help the hive? Incidence and impact of heritable microbes on bee health (BeeSymOverSpace)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United States,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2019-05-31
Duration (months): 32.0
Total project cost (EUR): 241169.4
EU funding (EUR): 241169.4
Participants: 2
Project status: CLOSED

Honey bees provide both economic and societal benefits, from the honey and other commodities that they produce to the pollination services they provide. The loss of honey bee colonies and the current threats to their health are of considerable concern to bee-keepers and biologists alike. This project seeks to examine how a particular aspect of honey bee biology – the symbiotic microbiome – impacts upon honey bee health. Studies in other systems reveal heritable microbes as important modulators of disease susceptibility. This project will utilize the extensive network of bee samples across the US and UK to establish geographical patterns of heritable microbe presence in bees, and links to apiculture practice. It will then use state of the art transcriptomic and genomic approaches to establish the links between Arsenophonus, a heritable symbiont known in bees, and bee health. It will then, combine with professional agencies responsible for bee health to use these results to modify apiculture practice to establish better bee husbandry. Aside the research science completed, the project will train an EU scientist in state of the art genomic technologies and translation from discovery to applied science. It will further transfer the training gained to EU hosts, both in discovery science and application.