Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Demonstration at industrial scale of the FLeXible manufacturing of SMART multifunctional photovoltaic building elements (SMART-FLEX)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable electricity generation
Action type: Collaborative project
Countries involved: Lithuania,Spain,Switzerland,Germany,Lithuania,Lithuania,Germany
Call:  (FP7-ENERGY-2012-2, 2012)
Start date: 2013-11-01
End date: 2017-05-31
Duration (months): 43.0
Total project cost (EUR): 4819706.34
EU funding (EUR): 2914482.0
Participants: 8
Project status: CLOSED

Building integrated photovoltaics (BIPV) is a promising area while it is still considered as a novelty dedicated only to exclusive construction. However, BIPV potential is much greater and many more solutions could be developed and BIPV could become a broadly accepted technology if the main barriers, hindering the market deployment are overcome. SMART-FLeX consortium aims to address the identified needs for overcoming the main barriers of BIPV market deployment by proposing the collaborative project with the following overall objective: - To demonstrate the multi-functional glass/glass PV building element as plug & play AC device for safe and easy installation into building electricity system. Demonstration of such device will cover both levels: (i) demonstration of flexibility and adaptability of manufacturing the customised design PV building elements, allowing harmonious integration in buildings and (ii) demonstration of such BIPV products in the building envelope. Wide deployment of BIPV, as low carbon technology, would contribute to the achievement of the goals of diversification of European energy portfolio and climate change. If successfully demonstrated SMART-FLeX solution will lead to fast market replication and enhance large deployment of BIPV in short term, also contributing to the market share of RES increase in 6,73% and CO2 savings in 238 k tones during ten years after implementation.

Keywords: building integrated photovoltaics,microinverter,mppt,ac device
Closing the Loop between Understanding and Effective Treatment of the Basal Ganglia and their Disorders (CLUE-BGD)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: Israel
Call:  (ERC-2012-ADG_20120314, 2012)
Start date: 2013-12-01
End date: 2019-11-30
Duration (months): 72.0
Total project cost (EUR): 2476922.0
EU funding (EUR): 2476922.0
Participants: 1
Project status: CLOSED

In this project, the basal ganglia are defined as actor-critic reinforcement learning networks that aim at an optimal tradeoff between the maximization of future cumulative rewards and the minimization of the cost (the reinforcement driven multi objective optimization RDMOO model). This computational model will be tested by multiple neuron recordings in the major basal ganglia structures of monkeys engaged in a similar behavioral task. We will further validate the RMDOO computational model of the basal ganglia by extending our previous studies of neural activity in the MPTP primate model of Parkinson's disease to a primate model of central serotonin depletion and emotional dysregulation disorders. The findings in the primate model of emotional dysregulation will then be compared to electrophysiological recordings carried out in human patients with treatment-resistant major depression and obsessive compulsive disorder during deep brain stimulation (DBS) procedures. I aim to find neural signatures (e.g., synchronous gamma oscillations in the actor part of the basal ganglia as predicted by the RMDOO model) characterizing these emotional disorders and to use them as triggers for closed loop adaptive DBS. Our working hypothesis holds that, as for the MPTP model of Parkinson's disease, closed loop DBS will lead to greater amelioration of the emotional deficits in serotonin depleted monkeys. This project incorporates extensive collaborations with a team of neurosurgeons, neurologists, psychiatrists, and computer science/ neural network researchers. If successful, the findings will provide a firm understanding of the computational physiology of the basal ganglia networks and their disorders. Importantly, they will pave the way to better treatment of human patients with severe mental disorders.

Keywords: basal ganglia,deep brain stimulation,neural networks models,emotional dysregulation
Building a Human Tumour Microenvironment (CANBUILD)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Physiology, Pathophysiology and Endocrinology
Countries involved: United Kingdom
Call:  (ERC-2012-ADG_20120314, 2012)
Start date: 2013-06-01
End date: 2018-05-31
Duration (months): 60.0
Total project cost (EUR): 2431035.0
EU funding (EUR): 2431035.0
Participants: 1
Project status: CLOSED

Even at their earliest stages, human cancers are more than just cells with malignant potential. Cells and extracellular matrix components that normally support and protect the body are coerced into a tumour microenvironment that is central to disease progression. My hypothesis is that recent advances in tissue engineering, biomechanics and stem cell biology make it possible to engineer, for the first time, a complex 3D human tumour microenvironment in which individual cell lineages of malignant, haemopoietic and mesenchymal origin will communicate, evolve and grow in vitro. The ultimate aim is to build this cancerous tissue with autologous cells: there is an urgent need for models in which we can study the interaction of human immune cells with malignant cells from the same individual in an appropriate 3D biomechanical microenvironment. To achieve the objectives of the CANBUILD project, I have assembled a multi-disciplinary team of collaborators with international standing in tumour microenvironment research, cancer treatment, tissue engineering, mechanobiology, stem cell research and 3D computer-assisted imaging. The goal is to recreate the microenvironment of high-grade serous ovarian cancer metastases in the omentum. This is a major clinical problem, my lab has extensive knowledge of this microenvironment and we have already established simple 3D models of these metastases. The research plan involves: Deconstruction of this specific tumour microenvironment Construction of artificial scaffold, optimising growth of cell lineages, assembly of the model Comparison to fresh tissue Investigating the role of individual cell lineages Testing therapies that target the tumour microenvironment My vision is that this project will revolutionise the practice of human malignant cell research, replacing misleading systems based on cancer cell monoculture on plastic surfaces and allowing us to better test new treatments that target the human tumour microenvironment.

Keywords: tissue engineering,biomechanics,human tumour microenvironment,cancer metastases
Phenotypic plasticity, animal welfare, and the validity of animal experiments. (REFINE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Evolutionary, population and environmental biology
Countries involved: Switzerland
Call:  (ERC-2012-ADG_20120314, 2012)
Start date: 2013-05-01
End date: 2018-04-30
Duration (months): 60.0
Total project cost (EUR): 1333140.0
EU funding (EUR): 1333140.0
Participants: 1
Project status: CLOSED

Using animals for research is a privilege granted by society to scientists on the explicit understanding that such use will provide significant new knowledge, and no unnecessary harm will be imposed on the animals. However, a high prevalence of abnormal behaviour and other signs of distress in animals housed under standard laboratory conditions, and poor reproducibility of experimental results, suggest that current practice needs to improve to guarantee sound science. Recently we have shown in mice that standard housing conditions may interfere with behavioural control mechanisms expressed as overt behavioural disorders. These findings question both the animals’ welfare and the validity of research conducted with them. Furthermore, we have shown that current practice of standardisation may compromise the external validity of experimental results, resulting in poor reproducibility and spurious results. The overall hypothesis underlying this project is that both impaired welfare and poor reproducibility are caused by a failure to account for fundamental principles of phenotypic plasticity, whereby animal welfare is impaired when the animals’ adaptive plasticity is overtaxed, and reproducibility is compromised when phenotypic variation is standardised away. Based on this framework, the project, therefore, aims to systematically assess environmental effects on the welfare of laboratory animals and on the validity and reproducibility of animal experiments, using the mouse as a model species. The new results should greatly advance our understanding of environmental effects on the quality of life of laboratory animals and on the quality of science conducted with them. They should help to reconcile laboratory animal science with the biological principles of phenotypic plasticity, thereby providing significant new knowledge for effective Refinement of animal research. This should benefit the science as well as the animals in the best meaning of the 3R concept.

Keywords: animal experimentation,experimental design,external validity,animal welfare,phenotypic plasticity,abnormal behaviour,stress,cognition,perseveration
Information-theoretic approach to infer encoding patterns in a decision making process (NEUCOD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-09-01
End date: 2015-08-31
Duration (months): 24.0
Total project cost (EUR): 166336.2
EU funding (EUR): 166336.2
Participants: 1
Project status: CLOSED

The question of how stimuli and actions are encoded in the neuronal signals of the brain is at the central core of neuroscience research. In particular, very little is known about the mechanism for which a given decision posterior to a stimulus is manifested in the brain activity. Nowadays, simultaneous recordings of neurons in different brain regions bring an exceptional dataset to investigate the complex encoding mechanisms that underlie a decision making process. In the present project, the candidate will have exclusive access to one of these datasets which consists of brain recordings in primates during a decision making task. The candidate will employ his expertise in some areas of information theory and coding to formulate a novel hypothesis to be tested on these available data. This hypothesis states that causal interactions between neurons in a population encode information about decisions. This interdisciplinary line of investigation represents a changing point in the candidate’s career. On the one hand, the candidate will be trained in the neurophysiological aspects of the problem. On the other, he will develop emerging methods to capture causal interactions between neuronal responses and then represent the hypothesized “encoding patterns”. From a scientific point of view, this project will provide one of the key tools to understand information processing in a decision-making process and study sources of brain disorder based on the dynamics of encoding patterns. More generally, the present project will launch the candidate’s career in an interdisciplinary field that has potential application in academia and industry research, as well as will foster the collaboration between the information theory and the computational neuroscience communities, thus making this research area in Europe more competitive and attractive for future students and researchers.

Keywords: g106 informatics and information systems,l510 neuroimaging and computational neuroscience
Beyond Minimal Models at Three Frontiers (BMM@3F)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-03-06
End date: 2015-03-05
Duration (months): 24.0
Total project cost (EUR): 202405.8
EU funding (EUR): 202405.8
Participants: 1
Project status: CLOSED

I will investigate the phenomenology of non-minimal models with signatures at the three frontiers: energy, space and intensity. With such a large number of experiments current and future, it is now possible and vital to genuinely compare these to data, particularly in light of recent hints of new physics. The main classes of models to be investigated are: 1) Dirac gaugino models and their implications for Higgs physics at the LHC, which is now technically possible for the first time. 2) Models with one or many axions (that can now be searched for in many experiments) specifically LARGE volume string models; these should be related to the comology and spectra of these models, and hence collider signatures, which are still undetermined (previous work being out of date). 3) Models with additional U(1)s, which are being searched for at the intensity frontier.

Keywords: p102 particle physics,p101 fundamental interactions and fields
Role of Autophagy and Lysosomal Biogenesis in Hypoxia and Radiation-induced cell death in normal and cancer cells (HORAY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-09-01
End date: 2015-08-31
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

The aims of the project are to investigate, for the first time, the mechanisms and the role of autophagy and lysosomal biogenesis in hypoxia and radiation-induced cell death in normal and cancer cells. In project 1 we ask whether autophagy and lysosome biogenesis are involved in hypoxia and the acute and/or late toxicity of radiation in normal cells and tissues, and the eventual radioprotection that could be achieved by modifying process. We will study the direct effects of ionizing radiation and hypoxia on the autophagic pathway and lysosomal biogenesis in normal cell lines. Also, we will conduct a moderate-throughput siRNA screen of different autophagic variants and lysosomal biogenesis pathways in hypoxia and radiation in normal cells. Further, we will study the effects of ionizing radiation in liver conditional knockout or overexpressed mouse line of the master transcriptional regulator of autophagy and lysosomal biogenesis TFEB, and compare its radiation toxicity with the commercial available compound the amifostine. In project 2 we ask whether upregulation or downregulation of the autophagy and lysosomal biogenesis could enhance the radiation sensitivity in vitro and in vivo. We will identify mutants in fission yeast that are either protective from, or synergistic with ionizing radiation and link with autophagy and lysosomal biogenesis and will be further exam in breast cancer cell lines. We will conduct a moderate-throughput siRNA screen of different autophagic variants and lysosomal biogenesis pathways in radiation sensitivity in breast cancer cell lines. Also we will develop an inducible dox-shRNA for TFEB in a xenograft model and investigate the therapeutic value combined with radiation therapy. We anticipated to identify critical targets for pharmacological or molecular interventions aiming to selective protection of normal cells and enhancement of the efficacy of radiotherapy and/or chemotherapy of tumors.

Keywords: autophagy,lysosobal biogenesis,hypoxia,radiation,normal cell,breast cancer cell
Long Non-coding RNAs with specific regulation and function in the Drosophila Central Nervous System (LNCRNADROCNS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2014-07-01
End date: 2017-03-17
Duration (months): 24.0
Total project cost (EUR): 161968.8
EU funding (EUR): 161968.8
Participants: 1
Project status: CLOSED

The scientific and technical breakthrough of the draft sequence of the human genome in 2001 and the advent of genome wide technologies have dramatically altered our view of genome organization and function. We know now that more than 70% of the human genome is transcribed, although only 2% encode proteins. Within this huge percentage of supposedly “garbage” transcripts, thousands of long non-coding RNAs (lncRNAs) have been described. lncRNAs are characterized by their extensive regulation during development, particularly in the central nervous system (CNS), where some have been shown to affect cognitive and locomotor functions. Drosophila melanogaster is an ideal model for studying the role of lncRNAs during development and has been used successfully to investigate the molecular and cellular basis of neurodegenerative disorders. To address the relevance and functions of lncRNAs during CNS development, we plan to identify and characterize lncRNAs in Drosophila neurons by applying several innovative, robust, and genome wide technologies. Taking advantage of the power of Drosophila genetics, we will study the in vivo roles of selected CNS lncRNAs, at both the morphological and functional levels, in two mushroom body (MB) neuron paradigms. Using the most modern instruments and methods available, we will explore the neuronal functions of candidate CNS lncRNAs by their genetic knock-down and phenotypic analysis in vivo, analysis of their subcellular localization, trafficking and identification of their protein partners. To date, no systematic investigation of lncRNAs during CNS development addressing their expression patterns, localization and in vivo function in a living organism has been reported. Hence this interdisciplinary project, which will shed important insight into the biological functions of lncRNAs in the CNS, is both ambitious and novel.

Keywords: l502 molecular and cellular neuroscience,l101 molecular biology and interactions,l104 rna synthesis - processing - modification and degradation,l206 molecular genetics - reverse genetics and rnai
Autoimmune Reaction or Tolerance - Endosymbiont Mitochondria and the Immune System (ARTEMIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2014-08-01
End date: 2017-07-31
Duration (months): 36.0
Total project cost (EUR): 294456.3
EU funding (EUR): 294456.3
Participants: 1
Project status: CLOSED

Mitochondria, the powerhouses of our cells, are remnants of a eubacterial endosymbiont. Because mitochondria retain many hallmarks of their bacterial origin, they have recently been implicated in the etiology of systemic inflammatory response syndrome, a frequent cause of death in intensive care units. Remarkably, mitochondria are immunologically inert under normal homeostatic conditions, raising the fundamental question: how does the immune system distinguish mitochondria from resemblant bacterial pathogens? We hypothesize that mitochondria harbor distinct molecular signatures identifying them to the immune system. To address our hypothesis, we will investigate immune handling of intact mitochondria and mitochondria-derived danger-associated molecular patterns. The research objectives are to examine: 1) if isolated, intact mitochondria in vitro elicit pro-inflammatory signals or are recognized specifically as non-pathogenic by immune cells, 2) immune handling of intact and disrupted mitochondria in vivo by two-photon intravital microscopy, and 3) the role of innate signaling pathways in determining pro- or anti-inflammatory responses to mitochondrial challenges in vivo. The applicant has an international profile and an outstanding track record. He will combine a strong background in immunology with an interdisciplinary approach transcending the boundaries to organelle and symbiosis research. The project entails training in two-photon intravital microscopy at the outgoing host, the Immune Disease Institute, Harvard Medical School. This cutting-edge technique has emerged recently as a powerful tool for studying immune function in real-time in the intact organism. Hence, theoretical developments and technical innovations have converged to pave the way for the implementation of the proposed project, which will address fundamental mechanisms governing the balance between host immunity and autoinflammation, with a significant impact on human health and disease.

Keywords: l601 innate immunity,l602 adaptive immunity,l603 phagocytosis and cellular immunity,l605 immunological memory and tolerance,l612 biological basis of immunity related disorders,l810 symbiosis
Morphogenesis of de novo peroxisome formation (PEROXISCOPY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-04-01
End date: 2015-03-31
Duration (months): 24.0
Total project cost (EUR): 183469.8
EU funding (EUR): 183469.8
Participants: 1
Project status: CLOSED

PEROXISCOPY (peroxisome – microscopy) specifically aims at understanding the principles of de novo peroxisome formation. Peroxisomes have been discovered relatively recently (in 1954). Consequently, the level of understanding of their biology is relatively weak compared to the knowledge of other organelles. Despite their modest appearance, they are crucially important for cell vitality. Peroxisomes ubiquitously occur in eukaryotes, display an unprecedented versatility of functions and are essential in man. There are still major gaps in our current knowledge of peroxisome biology. PEROXISCOPY aims to study de novo peroxisome formation from the ER, the most debated topic in the peroxisome field. I will use correlative light and electron microscopy to detail structure and function of the de novo peroxisome formation machinery, starting from initiation on the ER till maturation of the pre-peroxisome. This research will elucidate fundamental issues regarding the molecular mechanisms behind organelle formation and provides the first contours of this developmental machinery. My research demands the combined expertise from different disciplines. This will be achieved by international collaborations with scientists from both universities and private sector. The originality of the proposal is high as it is based on very recent novel groundbreaking findings in the field of the novo peroxisome formation. My project is innovative since I will combine advanced microscopy techniques, which were not used in peroxisome research yet, with established biochemical and mass-spectroscopy methods. Summarizing, this project offers me an advanced research training, allowing me to mature into a scientist who can cope with the science and technology challenges in the molecular life sciences of the mid-21th century.

Keywords: peroxisome biogenesis,correlative light and electron microscopy,organelle formation,peroxisomal remnants,peroxins