Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Elucidating the Role of Clouds-Circulation Coupling in Climate (EUREC4A)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France,France
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-08-01
End date: 2022-07-31
Duration (months): 72.0
Total project cost (EUR): 3013334.0
EU funding (EUR): 3013334.0
Participants: 2
Project status: CLOSED

This proposal focuses on two of climate science’s most fundamental questions: How sensitive is Earth's surface temperature to radiative forcing? and What governs the organization of the atmosphere into rain bands, cloud clusters and storms? These seemingly different questions are central to an ability to assess climate change on regional and global scales, and are in large part tied to a single and critical gap in our knowledge: A poor understanding of how clouds and atmospheric circulations interact. To fill this gap, my goal is to answer three questions, which are critical to an understanding of cloud-circulation coupling and its role in climate: (i) How strongly is the low-clouds response to global warming controlled by atmospheric circulations within the first few kilometres of the atmosphere? (ii) What controls the propensity of the atmosphere to aggregate into clusters or rain bands, and what role does it play in the large-scale atmospheric circulation and in climate sensitivity? (iii) How much do cloud-radiative effects influence the frequency and strength of extreme events? I will address these questions by organising the first airborne field campaign focused on elucidating the interplay between low-level clouds and the small-scale and large-scale circulations in which they are embedded, as this is key for questions (i) and (ii), by analysing data from other field campaigns and satellite observations, and by conducting targeted numerical experiments with a hierarchy of models and configurations. This research stands a very good chance to reduce the primary source of the forty-year uncertainty in climate sensitivity, to demystify long-standing questions of tropical meteorology, and to advance the physical understanding and prediction of extreme events. EUREC4A will also support, motivate and train a team of young scientists to exploit the synergy between observational and modelling approaches to answer pressing questions of atmospheric and climate science.

Keywords: clouds,convection,climate,atmospheric circulation,climate sensitivity,cloud feedbacks,tropical meteorology,convective aggregation,storms,extreme events,atmospheric modelling,field campaign
Population-wide analysis of molecular and metabolic features intrinsic to dormancy variability in single seeds (POP1Seed)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Poland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-12-01
End date: 2023-11-30
Duration (months): 24.0
Total project cost (EUR): 137625.6
EU funding (EUR): 137625.6
Participants: 1
Project status: TERMINATED

Seed physiological quality is pivotal to ensure rapid and homogeneous seedling establishment required for stable yield and is a major economic challenge for the seed industry. Besides germination, vigor and storability or longevity, seed physiological quality also includes seed dormancy, i.e. the seed physiological stage preventing germination even under favorable conditions. While seed dormancy has been widely studied at population level, little has been done at single seed level. However, homogeneous seed lot production is crucial in plant breeding. In seeds, dormancy is mainly regulated by DELAY OF GERMINATION 1 (DOG1), a major Quantitative Trait Locus controlling seed dormancy. DOG1 expression is highly regulated, including by alternative polyadenylation which resulted in the discovery of functional DOG1 protein variant. However, whether this major QTL also regulates individual seed dormancy variability is still unknown. Here, this project combines several cutting-edge technologies such as single seed RNA sequencing analysis and mass spectrometry imaging to Genome Wide Analysis and mutant characterization to unravel novel regulators of single seed dormancy in Arabidopsis thaliana, with the perspectives to be applied on rapeseed. While improving my career prospects and learning from the establishment of international collaborations between the host institute in Poland and the academic partner IBMP-CNRS in France, this project POP1Seed is timely, and responds to expectations of the European Framework programme for Research and Innovation.

Keywords: seed dormancy,individual seed,mass spectrometry imaging,arabidopsis thaliana,brassica napus,metabolic,rna sequencing,genome wide analysis
Generation and maintenance of long-lived memory T cells in humans (PERSYST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Italy
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2021-05-31
Duration (months): 69.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Defining the molecular mechanisms governing memory T cell differentiation and homeostasis is of pivotal importance to generate durable and protective T cell responses against infections and cancers. Considerable knowledge in this regard has been acquired in mouse models but is still limited about human T cells. In particular, some mechanisms are assumed to occur in humans but were never formally demonstrated. We showed that memory T cells adoptively-transferred with bone marrow transplantation failed to persist in recipient hosts in the absence of antigen. By contrast, self/tumor-specific naïve T cells rapidly acquired T memory stem cell (TSCM) attributes and subsequently reconstituted the memory T cell pool by homeostatic differentiation. Current models indicate human TSCM cells as superior to conventional memory T cells in regards to effector potential and persistence capacity. Genome-wide expression analysis identified candidate TSCM cell-specific transcriptional regulators that were shown to inhibit senescence, promote self-renewal and regulate somatic differentiation. In this project, by using single cell technologies, primary human samples and in vivo humanized models, we will define the molecular mechanisms at the basis of memory T cell formation and maintenance in humans. We will initially define the antigenic requirement for the long-term persistence of memory T cells by following the fate of adoptively-transferred T cells. As the field remains unexplored, we will investigate the acquisition of memory attributes by self/tumor-specific T cells on multiple functional levels. The gene products specifically expressed by self-renewing TSCM cells will be finally tested for their capability to arrest T cell differentiation and generate long-lived memory T cells with enhanced stem cell-like properties. Our results will impact multiple physiological and pathological situations involving T cell-mediated immune responses.

Keywords: t cell differentiation,naive t cells,memory t cells,bone marrow transplantation,flow cytometry
GUIDANCE AND FUNCTION OF REGENERATIVE FIBERS IN ADULT CNS (DRIVE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2024-02-29
Duration (months): 72.0
Total project cost (EUR): 1499410.0
EU funding (EUR): 1499410.0
Participants: 1
Project status: SIGNED

The impairment of central nervous system (CNS) leads to irreversible loss of vital functions because, unlike young neurons, mature neurons are not able to regenerate. Thus, understanding the detailed mechanisms of axonal growth and repair remains one of the greatest challenges of neurobiology and for society. If the extrinsic factors fail to reach levels required for regeneration, manipulating intrinsic pathways has shown promising results. Particularly, my work demonstrated that the simultaneous activation of mTOR, JAK/STAT and c-myc pathways allows exceptional regeneration with axons close to their targets. However it also exacerbates previously described phenomenon of misguidance with potential aberrant circuit formation. My unique model opens up the possibility to explore these fundamental questions of CNS regeneration. I propose to address the yet unexplored problem of the guidance of regenerating axons in adults in order to promote the formation of a functional new circuit after injury. Indeed what are the modalities of guidance in the adult? Are axons still responsive to developmental guidance cues and are they still expressed? Can regenerative axons form connections with their targets and are these connections functional? To answer these critical questions, I will use the combination of state of the art biochemistry, imaging, and electrophysiology in an in-vivo and ex-vivo model of the visual system to 1) Understand axon guidance in mature system in order to properly drive regenerative axons to their brain targets and avoid aberrant projections, and 2) Analyze the formation of a functional optic nerve circuit after injury. Altogether, these results will generate major breakthroughs in a fundamental but uncovered mechanism of axon guidance during regeneration and the functionality of de novo formed circuits. They will open up new ways for innovative therapeutic development after CNS trauma but also to the large spectrum of neurodegenerative diseases.

Keywords: axon regeneration,functional recovery,circuit reformation,axon guidance
Innovative and compact process for recycling rubber suitable to improve the environmental footprint of the tyre industry over the life-cycle (REW-TYRES)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 3542500.0
EU funding (EUR): 2479750.0
Participants: 1
Project status: CLOSED

The project aims at developing and bringing to market an innovative process for recycling rubber in the tyre industry. The process is a sequence of mechanical operations implemented by a compact dedicated line and is foreseen in two versions that apply to different phases of tyres lifecycle: REWORK: main version that applies to tyre production to rework all scraps and non-compliant components and produce rubber 100% reusable in the main production; RECYCLE: a variant of process that applies to recovering rubber from end-of-life tyres (ELT) to produce sheeted rubber usable for moulded applications. Variants include pre-conditioning phases to clear rubber from textile cords. The two versions are conceived to serve different customer segments, REWORK for tyre manufacturers to improve eco-efficiency and reduce production costs, RECYCLE for recyclers of ELT to produce cleaner, more usable forms of recycled rubber suitable to open new high-value application opportunities and increase ELT management profit. In both segments business models and value chains are consolidated and needs to be served are explicit, thus creating a very favourable context for the exploitation. The project builds on a solid technological and business background. ELSY is the global leader of specialised machines and control systems for tyre and plastic industries. The process was conceived to respond to needs that came out from the day-by-day relationship with all the main manufacturers worldwide Projects aims at 1) developing enabling subsystems for REWORK and RECYCLE lines, 2) building prototype versions of the two lines, 3) carrying out validation tests, 4) carrying out industrialisation including design and suppliers engagement, 5) organising exploitation including engagement of key partners and definition of common business cases For ELSY the project is crucial in the strategy to expand vertically the offer in markets we already lead and enter in new market segments with excellent potential

Keywords: tyre recycling,end of life tyre recycling,elimination of rubber wastes,automated manufacturing process
Marine Renewable Infrastructure Network for Enhancing Technologies 2 (MARINET2)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Ireland,Ireland,Italy,Spain,Spain,Spain,Spain,Italy,Ireland,Belgium,Finland,Norway,Sweden,Sweden,France,France,France,France,Netherlands,Netherlands,Portugal,Denmark,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2016-1, 2016)
Start date: 2017-01-01
End date: 2021-12-31
Duration (months): 60.0
Total project cost (EUR): 10592285.23
EU funding (EUR): 10592285.23
Participants: 42
Project status: CLOSED

Integrating activities planned under MaRINET 2 build upon the achievements of the advanced community created in MaRINET FP7. MaRINET 2 will ensure the continued integration and enhancement of all leading European research infrastructure and facilities specialising in research, development and testing of offshore renewable energy systems including electrical sub systems and grid integration through a range of TRLs (1-7). MaRINET FP7 proved the added value of uniting these facilities, and substantially improving their capability as a community of practice to deliver consistent testing services ensuring, quantifiable, stepwise innovation and progress in the development of devices and key components, and identifying critical areas for further technical investigation and enhancement. Whilst activities proposed under MaRINET 2 will follow the same formula, balancing networking/ joint research/ and transnational access, the consortium and scope of work is expanded to include xx partners in xx countries with xx facilities. The e-infrastructure programme fills a strategic gap. Taking stock of existing capacities for data management/sharing; it addresses user requirements and demonstrates the operation of a new system based on standards and tools adapted from the SeaDataNet infrastructure. The European Commission and member states recognise offshore renewable energy as an important source of clean energy that can: generate economic growth and employment; increase energy security; and boost competitiveness and technological innovation. The realisation of this potential depends on the accelerated development, deployment and grid integration of reliable, efficient technologies for harvesting offshore renewable energy, which in turn requires robust and exhaustive testing in dedicated facilities operated by practitioners with specialised expertise. MaRINET 2 provides this ecosystem, and is pre-eminently suited to fostering the next generation of offshore renewable energy devices.

Keywords: offshore renewable energy,wave tidal wind,transnational access,training,networking,education,standards,joint research
Sustainable Polyesters and Renewable Terpenoid Monomers (SUPREME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-08-25
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Synthetic polymers derived from petrochemical products are essential for the production of a wide range of consumer products. The demand for more sustainable and renewable monomers and polymers is currently increasing, because fossil feedstock will become scarce in future times, and the global legislation is putting an increasing stress on the use of certain monomers used in the polymer industry. The aliphatic polyesters represent one of the most appealing type of bioplastic materials, because of their general biocompatibility and facile hydrolytic degradation and, in this ambit, the use of terpenes as monomers or monomer-precursors is largely unexplored. The primary objective of this project, is the creation of new polyester formulations based on renewable and accessible terpene monomers to answer to the growing need for future generations of more functional and sustainable materials. Three renewable monomers have been selected, two derived from camphor and a new one from β-elemene. Structurally new polyesters will be synthesized by ring opening (co)polymerization of these monomers, using catalytic systems based on cheap and health-friendly metals (Fe, Al). The use of the new β-elemene based monomer will incorporate vinylic groups along the polymer chains, offering the possibility for post-modification of the obtained material. The success of the project is supported by the Experienced Researcher background in polymer synthesis with the Host experience in the discovery and catalytic valorization of new terpene scaffolds. The action will take place in an interdisciplinary and international environment, granting to the Experienced Researcher a solid train in scientific and soft skills needed for his future career. The results of the action will have a strong impact on the society, giving the opportunity to asses circular economy on a highly impact industrial sector, such as that of bio-polymers.

Keywords: biopolymers,terpenes,aliphatic polyesters,catalysis,ring opening co polymerization,post modification,renewable sources
Water – Electricity – Telecommunication Package (WETPaC)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Greece
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-12-31
Duration (months): 8.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Clean water, electricity and communication are crucial for human well-being and sustainable socioeconomic development. Their provision is in deficiency in most rural areas of the world and in specific Mediterranean areas of Europe. Yet, solutions for the above needs are developing very slowly due to lack of funds and the risks associated with payments for the supplied services. The proposing SME aims to develop and demonstrate an optimised packaged system (WETPaC) to provide these services in a low carbon, energy efficient and sustainable way. Key to overcome the relevant barriers is the development of a remote maintenance and operation system as well as the introduction of smart payment methods for electricity and water. The innovative aspects of WETPaC will facilitate its financing. This will lead to the involvement of local entrepreneurs who will develop a sustainable business in selling electricity, water and services (e.g. electricity, air conditioned shelters, etc.) to telecom companies. The main objective of the proposed project is to perform a feasibility assessment and a detailed business plan for the successful implementation of WETPaC. Based on the results of “Phase1”, the proposing SME plans to develop and demonstrate a prototype with the help of investors and/or “SME – instrument – Phase 2”. WETPaC will address a global challenge based on European design, components and equipment. Successful commercialisation will provide valuable services that will improve quality of life and will consequently help develop new jobs in Europe as well as in developing countries. The feasibility study will have as priority the Greek islands where it is suitable for touristic businesses and Philippines where it can supply villages. Other countries will be also examined. During the study, the proposing SME will contact key stakeholders and potential customers. It will also examine possible technical features that could make the product more affordable and attractive.

Keywords: rural electrification,potable water,telecommunications,remote maintenance and operation,smart payment,renewable energy