Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Brain networks controlling social decisions (BRAINCODES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-09-01
End date: 2024-02-29
Duration (months): 78.0
Total project cost (EUR): 1999991.0
EU funding (EUR): 1999991.0
Participants: 1
Project status: SIGNED

Successful social interactions require social decision making, the ability to guide our actions in line with the goals and expectations of the people around us. Disordered social decision making – e.g., associated with criminal activity or psychiatric illnesses – poses significant financial and personal challenges to society. However, the brain mechanisms that enable us to control our social behavior are far from being understood. Here I will take decisive steps towards a causal understanding of these mechanisms by elucidating the role of functional interactions in the brain networks responsible for steering strategic, prosocial, and norm-compliant behavior. I will employ a unique multi-method approach that integrates computational modeling of social decisions with new combinations of multimodal neuroimaging and brain stimulation methods. Using EEG-fMRI, I will first identify spatio-temporal patterns of functional interactions between brain areas that correlate with social decision processes as identified by computational modeling of behavior in different economic games. In combined brain stimulation-fMRI studies, I will then attempt to affect – and in fact enhance – these social decision-making processes by modulating the identified brain network patterns with novel, targeted brain stimulation protocols and measuring the resulting effects on behavior and brain activity. Finally, I will examine whether the identified brain network mechanisms are indeed related to disturbed social decisions in two psychiatric illnesses characterized by maladaptive social behavior (post-traumatic stress disorder and autism spectrum disorder). My proposed work plan will generate a causal understanding of the brain network mechanisms that allow humans to control their social decisions, thereby elucidating a biological basis for individual differences in social behavior and paving the way for new perspectives on how disordered social behavior may be identified and hopefully remedied.

Keywords: functional neuroimaging
Active Living Infrastructure: Controlled Environment (ALICE)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: United Kingdom,United Kingdom,United Kingdom
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-03, 2018)
Start date: 2019-06-01
End date: 2020-11-30
Duration (months): 18.0
Total project cost (EUR): 99970.0
EU funding (EUR): 99970.0
Participants: 3
Project status: CLOSED

Active Living Infrastructure: Controlled Environment takes the form of a cabin. Providing a publicly accessible interface that is activated by household waste, namely urine and grey water, it exploits the properties of the integrated bioreactor system developed for the Living Architecture (LIAR) project. Creating a useable context and habitat that can be exhibited at biennales or festivals and explored by these audiences, it catalyses a conversation about the future of sustainability in homes and public buildings, as well as the lifestyle changes implicit in adopting this new generation of utilities. ALICE is a highly personal experience where 'users' may understand how waste can be dealt with differently in the home by putting it to good use. Through an attractive digital interface that translates data into graphical animations, participants will be able to see how their waste 'enlivens' the cabin's performance by, for example, turning on LEDs, or charging small mobile devices. Conceptually, ALICE may be likened to the 'tamagotchi pet', a digital toy that flourishes through the owner's digital care and attention. In this way, 'care' for ALICE is through its feeding and engagement with audiences. The system will also collect data that will help the innovators better understand the performance and potential usage of such a system outside the laboratory space so that appropriate prototypes for market can be developed.

Keywords: microbial fuel cell,design experience,social pedagogical interaction,sustainability
Boosting Widening Digital Innovation Hubs (BOWI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Spain,Bulgaria,Romania,Norway,Poland,Romania,Finland,Poland,Lithuania,Latvia,Czechia,Netherlands,Denmark
Call: Smart Anything Everywhere (H2020-DT-2019-1, 2019)
Start date: 2020-01-01
End date: 2023-06-30
Duration (months): 42.0
Total project cost (EUR): 8003158.47
EU funding (EUR): 7838134.98
Participants: 15
Project status: SIGNED

BOWI project addresses the challenge of limited capacities among DIHs to support the uptake of SAE/I4MS technologies during the last 7 years in the European industry at large. The overall aim of the project is to create a DIH widening network that supports the collaboration of new DIHs (proto-hubs) in regions where SAE and I4MS technologies are underrepresented and well-established DIHs that are highly experienced in these technologies (mature hubs). BOWI takes the first step towards creating a fully sustainable post-project network by: 1. Strengthening proto-hubs by carrying out actual experiments and facilitating the collaboration between proto-hubs and mature hubs; 2. Ensuring sustainability of BOWI network by developing a blended financing accelerator and membership model; 3. Creating the BOWI community, initiating the participation of proto-hubs, mature hubs, regional stakeholders, and investors. The mechanism will be first tested by supporting 6 pioneer proto-hubs (pioneer stage), which will be later extended to 9 proto-hubs in the second full-fledged strengthening stage, allowing new members of the EU DIH community to participate, including the proto-hubs and mature hubs that are currently not part of the consortium. The post-project BOWI network business model is to be explored, including service and funding needs. To ensure practical experience, all 15 proto-hubs will be supported to conduct 60 (15x4) SAE/I4MS uptake experiments with SMEs in total. For this purpose, an extensive FSTP approach will be used. The consortium includes experienced partners that participate intensively in the SAE/I4MS strategies (Civitta, FBA, VTT, and RWTH). They are complemented by 6 proto-hubs from various countries that act as pioneer hubs to test and validate approaches (TIT, LITC, UWB, KTP, NTNU, ICT).

Keywords: digital inovation hubs,widening,dih network,i4ms
Programmable dynamics of locally multistable metamaterials (ProgLMMsDyn)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-06
End date: 2023-04-05
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Metamaterials have gained importance across disciplines, owing to their superior and tailorable characteristics and performance. Alongside classic metamaterials with optimal properties such as customised stiffness, density, wave dispersion, and energy absorption, reconfigurable metamaterials have recently begun to attract attention. Reconfigurability can be achieved by interconnected multistable elements that possess more than one stable state. Controlled and cooperative switching of large arrays of such multistable elements leads to dynamic transition events of interest for applications ranging from haptic interfaces and morphing surfaces in 2D to shape-morphing and deployable structures in 3D. This research will focus on a new class of locally multistable 2D metamaterials of great potential for haptics (capable of conveying static and dynamic tactile sensations), while providing the general theoretical basis and new physics for a myriad of applications in both 2D and 3D. We consider multistable systems with unprecedented numbers of stable equilibria, leading to highly complex transitional behaviour beyond what has been studied so far and beyond what is tractable by available theories. This calls for new theoretical modelling, simulation tools, and experimental prototyping for validation, which lay the foundations for the main goal of producing a novel interactive haptic interface. The research is divided into three stages. The first is model development and system identification to facilitate theoretical and efficient numerical descriptions of the system to be experimentally investigated. The next stage uses machine-learning to identify target reconfiguration (both static and dynamic) utilising minimal actuation. The final stage estimates the loads introduced into the system using an asymptotic solution of the system’s dynamics. These constitute a step forward in the research of reconfigurable metamaterials and serve as a basis for countless applications.

Keywords: programmable metamaterials,reconfigurable metamaterials,local multistability,system identification,underactuated systems,nonlinear dynamics,reduced order modelling,transitional waves
Release of engineered extracellular vesicles for delivery of biotherapeutics (DELIVER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Nucleic acid-based medicines have opened a new avenue in drug discovery to target currently undruggable genes and to express therapeutic proteins, unlocking novel therapeutic options for a range of diseases, including neurodegeneration. However, they need to be encapsulated in nanocarriers to ensure their stability and efficient uptake into cells and tissues. Synthetic nanoparticles based on cell-penetrating peptides (CPPs) and, particularly, lipid nanoparticles (LNPs) have recently emerged as potent vectors for hepatic delivery. However, these systems fail to robustly target other organs in a safe manner. Another promising nanocarrier for advanced drug delivery is extracellular vesicles (EVs) that have the ability to efficiently convey macromolecules into cells. As native nanoparticles, EVs benefit from immune tolerance as well as the ability to cross biological barriers to reach, for example, the brain. We have developed advanced strategies to bioengineer cells to generate EVs loaded with therapeutic RNAs and proteins. However, their production at scale is cumbersome and time consuming. Here, I propose a platform development using synthetic nanocarriers to transiently engineer hepatic cells in vivo and harness EVs to functionally DELIVER biotherapeutics to currently unreachable, distant organs, focusing on brain. To achieve this, genetic constructs will be developed that allow for transient in situ engineering of cells in vivo and release of cargo (e.g. CRE)- laden EVs, displaying CNS-specific peptides, that can be functionally transported to distant organs, including brain. We will exploit the same strategy using CPP-based nanoformulations, recently developed in my lab, injected locally in brain to secrete EVs loaded with the disease-relevant protein GBA1 as a treatment strategy for Parkinson´s disease. Long-term this novel project has enormous potential, as any engineered EV could be produced in situ and be used for delivery of virtually any biotherapeutics.

Keywords: cell engineering,exosomes,extracellular vesicles,drug delivery,gene therapy,rna delivery
European Marine Biology Resource Centre preparatory phase 2 (pp2EMBRC)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Spain,Spain,Israel,Italy,Norway,Belgium,Finland,Belgium,Greece,France,France,United Kingdom,United Kingdom,Portugal,United Kingdom,Portugal
Call: Preparatory Phase of ESFRI projects (H2020-INFRADEV-1-2015-2, 2015)
Start date: 2015-10-01
End date: 2016-09-30
Duration (months): 12.0
Total project cost (EUR): 975520.0
EU funding (EUR): 975520.0
Participants: 19
Project status: CLOSED

EMBRC is a distributed infrastructure of marine biology and ecology, encompassing aquaculture and biotechnology, exploiting the latest “omics”, analytical and imaging technologies, and providing on site and remote scientific and technical services to the scientific community of the public and private sector. EMBRC successfully completed a preparatory phase in early in 2014 with the production of a business plan and a memorandum of understanding (MoU) signed by 9 countries. A host for its headquarters has been chosen and and an ERIC application is in preparation. Since only institutions from 5 MoU signatory countries went through the preparatory phase, the present proposal has as objectives: 1) to harmonize the access mechanism to the operational EMBRC-ERIC across all the partners, putting all the practical tools in place, including host contracts and single point online access platform, to enable EMBRC-ERIC to commence its access program; 2) to put in place practical guidelines towards the full implementation of the new European and international legislation and commitments on access and fair benefit sharing of the use of marine biological resources, thus providing clarity to future users of EMBRC-ERIC about their legal rights over obtained biological resources, and positioning itself globally as a broker between users and the supplying countries ; 3) to focus the smart specialization of the regions onto the opportunities marine biological resources offer for blue-biotech development and innovation, thus demonstrating the member states that EMBRC is a tool towards economic development of their maritime regions, and enticing them to sign the EMBRC-ERIC, and prioritize its sustained support, particularly from regions which are now underrepresented in EMBRC (Black and Baltic Seas). These activities will ensure that the beneficiary research communities can exploit the results obtained at EMBRC-ERIC facility from the start with the highest efficiency.

Keywords: access provision,nagoya protocol,regional stakeholders,financial sustainability
Troy+ stomach stem cells in homeostasis, repair and pathogenesis (Troy Stem Cells)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany,Austria,United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-08-01
End date: 2020-07-31
Duration (months): 60.0
Total project cost (EUR): 1570398.99
EU funding (EUR): 570478.12
Participants: 3
Project status: CLOSED

The adult mammalian stomach can be divided into three distinct parts: From the proximal fore-stomach over the corpus to the distal pylorus. Due to constant exposure to mechanical stress and to hostile contents of the lumen, highly specialized cell types have to be constantly reproduced in order to maintain the function of the gastrointestinal tract. Recently, the applicant identified Troy+ chief cells as a novel stem cell population in the corpus epithelium. Troy+ chief cells displayed a very low proliferation rate indicating their quiescent nature compared to other known gastro-intestinal tract stem cells. Interestingly, these stem cells can actively divide upon tissue damage, suggesting distinctive statuses under conditions of homeostasis and injury. As Troy+ stomach stem cells exhibit interconvertible characteristics i.e. quiescent and proliferative, they represent a unique model of adult stem cells with which we can study 1) the dynamics of stem cell propagation in homeostasis and regeneration and the underlying mechanism of this switch by analysing molecular and epigenetic profiles. Subsequently, by analysing mRNA expression profiles and epigenetic changes in Troy+ stem cells between homeostasis and injury repair, we will generate a list of genes with potentially interesting functions in cell fate decisions. We will therefore investigate 2) the stomach stem cell programme in homeostasis and regeneration using in vitro and in vivo functional genetics. Lastly, we will characterise 3) human stomach stem cells in normal and pathological conditions. Here we pursue three main aims: - Investigating Troy+ stem cell dynamics during homeostasis and injury repair - Unmasking the stomach stem cell programme using in vitro and in vivo functional genetics - Characterising human stomach stem cells

Keywords: stomach,stem cells,lineage tracing,wnt signalling,organoid culture
Glare control with media functionality - VideowindoW (VW)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In urban environments, glass offers transparency to buildings and public spaces. It is however always accompanied by glare control solutions to manage the amount of light and heat entering the building. VideowindoW has developed a revolutionary alternative to conventional blinds or awning, which eliminates the choice between daylight or transparency. Multiple transparent modules are integrated into the glass façade, each module consisting of tiny LCD-segments (‘pixels’). The transparency of these pixels is independently controlled at very high speed. This enables the transformation of the glass façade into a transparent media platform. The content shown in the glass façade simultaneously serves as glare control. By using light sensors in combination with a proprietary algorithm the density of the content is calculated to yield the required degree of transparency. VideowindoW reduces energy consumption up to 30% (of which 20% climate control and 10% interior lighting). These savings help customers achieve sustainability goals. Customers now even have the opportunity to turn glass into a source of revenue, as it is transformed into potential advertising space by VideowindoW. The proposed SME-Instrument project is aimed at the European scale-up of the VideowindoW technology towards high-traffic locations, such as public transport hubs). VideowindoW offers a revolutionary glare control technology with added media functionality and lower energy use, that can be applied to many other market segments as well. Each of these might require a different market approach and tailormade business model. Specific objectives in this Ph1-study are to explore promising business cases for VideowindoW in public transport hubs, identify other promising market segments, define potential business models to help determine value-based pricing, research how VideowindoW can be optimally integrated in new and existing buildings, and elaborate on a detailed business plan for European scale (D1).

Keywords: architecture,glare control,transparency,display
Integrated pyrolisis and thermal cracking technology to revolutionise the MSW treatment market (Pirocrack)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Waste disposal is one of the biggest problems that the world is facing. Increasing population, urbanization and industrialization are accelerating drastically the generation of Municipal Solid Waste (MSW). Landfilling is the usual method but is the least recommended option since they release GHG, contaminates the soil and ground water, produces unpleasant odours and spread pathogenic microorganisms. Recycling is unable to deal with the huge amount of garbage produced. Mass-burn incineration eliminates waste but emits highly dangerous dioxins and furans creating major social opposition. Composting is limited to large fractions of organic waste and is very odorous. Most of the gasification plants that started to operate have shut down failing to provide a solution to the problem. New clean and cost-efficient technologies to dispose this huge amount of garbage are urgently needed. PYROCRACK uses a patented Pyrolysis process to treat MSW obtaining a mixture of liquids, gases and solids with high energy content and a novel Thermal Cracking process that improves the quality of this mixture. Pyrolysis decomposes waste without using O2 which avoids pollutant emissions. Thanks to its endothermic feature it transforms waste into high value products that can be commercialised in the industry making of PYROCRACK a flagship of the Circular Economy. Pyrolysis has been known for centuries but now it is the focus of the MSW treatment business because of the inability of the existing techniques to respond to the ever-growing generation of garbage. Our approach is disruptive since we will treat MSW in a distributed manner through profitable and clean small/medium plants located closer to households and businesses to transform the content of waste into usable products (biochar, syngas and power). Our aim is to reach a gradual and scalable market implementation in Solid Waste Market of the PYROCRACK technology so has to reach a ROI of 6,59 and a payback period of 2,25 years.

Keywords: municipal solid waste,pyrolisis,circular economy,biochar,syngas,waste disposal