Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unerstanding and predicting the Resilience of marine ecosystems (ROMANCE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: CLOSED

The impacts of climate change are now more pervasive than ever before in human history. Marine ecosystems have been particularly impacted by climate change, with several of them being at the brink of collapse. As a response, the international efforts to reduce carbon emissions have never been so ambitious. However, even in the most optimistic CO2 emission scenarios, the planet will continue to warm and experience the effects of climate change over the coming decades. For this reason, several international conservation targets have been set to maintain the resilience of marine ecosystems to climate change. Despite these calls, resilience research has been hampered by a lack of coherent ways to quantify it and the limited availability of empirical data. ROMANCE overcomes these limitations by taking an interdisciplinary approach to understand and predict the resilience of threatened Mediterranean marine ecosystems to current and future climate change. More specifically, in ROMANCE I will (1) study the resilience of marine communities to past marine heatwaves, (2) develop a deep algorithm to detect early warning signals of collapse and (3) use cutting-edge to predict the resilience of marine communities to different climate change disturbances. The results arising from ROMANCE will provide relevant information for the application of EU directives, especially related to climate change adaptation and coastal resilience, as well as a great leap for the applicant’s career, with valuable training and high-level publications expected.

Keywords: climate change,conservation,corals,marine heatwaves,mediterranean,regime shifts,resilience
Near-Earth Object's Forcast of Collisional Events (NEOForCE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: CLOSED

The modern world is subject to many natural, man-made and social dangers. Many of them are global in nature, as they threaten the very existence of human civilization. Notable among them is the danger of Earth collision with space bodies of cometary and asteroid nature. At present, there is no doubt about the importance and urgency of this problem. In particular, this is evidenced by a report of the National Science and Technology Council, USA, where the importance to detect and characterize the Near-Earth Objects (NOE) population and to prevent and respond to NEO impacts on Earth is outlined. To protect our planet from the dangers of collision with small bodies, it is first of all necessary to understand from which specific of almost 1 million bodies the Earth needs to be protected. The project aims to make a system to search for possible threats to the Earth from space bodies which will be independent from the ones that are now being operated in NASA and ESA. My project NEOForCE has several objectives: 1) develop new methods for estimating of the impact probability of a small body with the Earth 2) develop methods for obtaining more reliable estimates of orbital parameters and their uncertainties 3) make a search for old observations of known objects. Several web-services at the Institut de Mécanique Céleste et de Calcul des Ephémérides, Paris observatory will be launched that will include: 1) list of potentially colliding with the Earth asteroids and comets with their impact probability values 2) list of possible close encounters of asteroids and comets with the Earth 3) list of old observations made on photographic plates many years ago (even centuries) with the identifications to the objects imaged on them.

Keywords: orbital dynamics,near earth objects,asteroids,comets,celestial mechanics
Telecommunications and Computer Vision Convergence Tools for Research Infrastructures (CONVERGE)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Technology and infrastructures
Action type: Research and Innovation actions
Countries involved: Portugal,Finland,Spain,France,United States,United Kingdom
Call: R&D for the next generation of scientific instrumentation, tools and methods (HORIZON-INFRA-2022-TECH-01, 2022)
Start date: 2023-02-01
End date: 2026-07-31
Duration (months): 42.0
Total project cost (EUR): 8025202.75
EU funding (EUR): 8025202.75
Participants: 16
Project status: SIGNED

Telecommunications and computer vision have evolved as separate scientific areas. This is envisioned to change with the advent of wireless communications with radios characterised by line-of-sight ranges which could benefit from visual data to predict the wireless channel dynamics. Computer vision applications will also become more robust if helped by radio-based imaging. This new joint research field relies on wireless communications, computer vision, sensing and machine learning, and it has a high innovation potential because of the large domain of innovative applications it enables and the relevant know-how available in Europe. However, the full potential of this new area can only be evaluated if adequate Research Infrastructures (RI) and tools are available. The main objective of the CONVERGE project is the development of an innovative toolset aligned with the motto “view-to-communicate and communicate-to-view”. This toolset is a world-first and consists of vision-aided large intelligent surfaces, vision-aided fixed and mobile base stations, a vision-radio simulator and 3D environment modeler, and machine learning algorithms for multimodal data including radio signals, video streams, RF sensing, and traffic traces. This toolset will be deployed into 7 RIs mostly aligned with the ESFRI SLICES-RI and improve their competitiveness. CONVERGE will also provide the scientific community with open datasets of experimental and simulated data obtained with the toolset in the RIs, meet scientific and industrial requirements by addressing relevant 6G verticals, enhance the competitiveness of the involved companies, extend the European influence to world-wide recognised RIs, enable the creation of new RIs, contribute to the development of new environment-friendly tools, and help European Union to address its societal challenges.

Keywords: 6g reconfigurable intelligent surfaces vision aided base station open air interface 3d modelling ray tracing simulation machine learning algorithms microwave holography lidar video cameras
In vitro and In-cell characterization of Quadruplex-duplex hybrids: conformation, folding, and recognition by drug-like ligand molecule (QDHassay)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: CLOSED

Nucleic acids are intrinsically polymorphic. Apart from the Watson-crick duplex, guanine-rich sequences can form G-quadruplex (G4) structures, which have become attractive targets for small molecule ligands. It is now proven that G-quadruplexes can form in cells. Today most biophysical and structural/ligand binding studies are carried out in dilute aqueous solutions and the presence of artificial crowding agents/cosolvents. Still, recent works suggest that the folding of G4s may differ in the cellular milieu context due to the agents' limitations. Thus there is an immense need for in-cell-based structural biology approaches. In the proposal, I aim to address critical milestones leading to the bioactive conformation inside the cell and the development of effective/specific G4 targeting drugs using an essential sub-class of G4 structures as a paradigm, namely quadruplex−duplex hybrids (QDH-hereafter). We will focus on low- and high-resolution spectroscopic approaches and mass spectrometry-based ligand screening assays characterizing ligand-QDH interaction. On the methodological part, we will develop in-cell NMR in "native" conditions (starting from unfolded conformation: denovo folding) and propose a ligand screening assay inside the cellular system. Our project will contribute to unveil fundamental principles of nucleic acid folding. It will also foster collaboration between two European institutes specialized in complementary biophysical and structural approaches to study biomolecular folding. In a nutshell, the Maria Skłodowska Curie fellowship will flourish my scientific excellence and the resilience needed for my original ideas to become a reality and communication and public engagement skills across cultures and disciplines.

Keywords: nmr,in cell nmr,nucleic acids,quadruplex duplex hybrid,dna drug interaction
Microbial Synthetic in vivo Cell Therapy Systems (MiStiC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1499938.75
EU funding (EUR): 1499938.75
Participants: 1
Project status: SIGNED

Bacteria are among the most brilliant chemists on Earth. They are capable of producing a wealth of structurally diverse natural products with a wide range of applications in medicine, such as the treatment of infections and cancer. The synthetic production of microbial natural products and their transformation into pharmaceutical drugs is often a challenging, costly and time-consuming process due to the structural complexity of these molecules and the difficulties associated with drug solubility and formulation. An emerging new strategy in disease treatment aims to exploit beneficial intestinal microbes for ‘local’ drug production and delivery. Such commensal bacteria are safe, can be administered easily, and can be engineered to detect diseases and release drugs in adequate local concentrations. However, the current therapeutic platform or ‘chassis’ strains cannot stably colonize the human gut and have so far only been engineered to produce therapeutic proteins, such as hormones or cytokines. As a result, no commensal chassis strains are available to treat chronic intestinal diseases or to produce clinically important natural product therapeutics. In MiStiC, I propose to revolutionize microbial therapy systems by developing the beneficial, stable and prominent gut colonizer Clostridium leptum as an innovative and superior chassis for long-term health monitoring and chronic disease treatment. I will combine my expertise in molecular microbiology, enzyme engineering and natural product biosynthesis to equip the chassis with a nanobody-based biosensor and biocontainment modules, and optimize it for the expression of natural product biosynthetic pathways. As a proof-of-concept, we will implement these tools and chassis strains for the detection and treatment of colorectal cancer. Together, these innovations will have broad translational applications and will pave the way to a new frontier in the field of microbiome engineering and synthetic microbial therapy systems

Keywords: microbial natural products,specialized metabolism,human microbiota,cell factories
Turn the extra light on: enhancing the discovery potential of Higgs production in association with a photon (PLUSPHOTON)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1433125.0
EU funding (EUR): 1433125.0
Participants: 1
Project status: SIGNED

The observation of the Higgs boson in 2012 marked a significant milestone in particle physics. Following its discovery, the Large Hadron Collider experiments have focused on an extensive characterisation of this scalar particle. However, key questions remain, such as the origin of the electroweak scale and phase transition in the early Universe. This project seeks to address a crucial gap in our understanding of the Higgs boson: a comprehensive study of the Higgs boson production in association with a photon, focusing on the diphoton decay channel, could potentially point to new physics beyond the Standard Model. This process has not yet been observed due to its low cross-section and the relative softness of the extra photon. For this work, four main research objectives are considered. The first is to develop a novel experimental photon isolation technique, soft-drop isolation, with the aim of improving photon isolation at low-transverse momentum. The second one is to produce a complete characterisation of the background from the strong interaction with differential cross-section measurements that can assess the modelling of state-of-the-art Monte Carlo event generators. The third one is to search for Higgs plus photon production in the diphoton decay channel, establishing a framework in which the rich phenomenology of this process can also be studied in other decays. The final one is to evaluate the results in terms of the Standard Model Effective Field Theory and shed light on the origin of potential new physics effects if any deviations from the current theory are found. The project will unlock deeper insights into the Higgs boson´s interactions with fundamental particles, sharpening our grasp of the electroweak symmetry breaking mechanism. It will lay the groundwork for searches in alternative Higgs decay channels and introduce a novel photon isolation technique that will transform the landscape of photon measurements.

Keywords: large hadron collider,higgs boson,electroweak symmetry breaking,photon isolation,monte carlo modelling,standard model effective field theories
Circular lignin materials from well-defined functional building blocks (CIRCULIG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Lignin is a nature’s wonder material that allows trees to grow vertically and have strong and biochemically resistant structures. However, the majority of lignin is burned in the forest industry. The objective is to make a paradigm shift in the use of lignin by developing circular lignin materials with functionalities arising from well-defined nanostructures. This project faces two outstanding challenges. The first relates to overcoming the instability of lignin nanoparticles in organic solvents and under alkaline conditions, which currently restricts synthesis of advanced lignin materials. The second is to develop lignin nanoparticles and lignin fibres structurally incorporating inorganic and metal nanoparticles. By overcoming these obstacles, we will have functional lignin building blocks for circular vitrimer adhesives, electrochemical catalysts, magnetically responsive nanocomposite gels, and colloidal crystals. Synthesis and assembly of these materials requires considerable contributions to method development that will open wholly new frontiers for sustainable lignin materials. Far-reaching implications beyond materials science include excellent opportunities for interdisciplinary studies across environmental sciences, chemical and process engineering, and life sciences.

Keywords: lignin hybrid nanocomposites nanoparticles nanofibres colloidal crystals
Feeling awake while asleep: A neurophenomenological study of sleep state misperception in insomnia and narcolepsy (PhenoSSM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-15
End date: 2027-09-14
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 2
Project status: SIGNED

Sleep is a basic need that represents a critical public health issue when disturbed or insufficient. Sleep state misperception (SSM) – the mismatch between subjective reports (what individuals perceive) and objective measures (what sleep specialists record) – complicates the diagnosis and treatment of sleep disorders. SSM is common in sleep disorders, including insomnia and narcolepsy, both of which struggle with managing the transition from wakefulness to sleep and exhibit severe overestimation of sleep onset latency. Despite recent advances in understanding the neurophysiological aspects of SSM, its subjective dimensions remain largely unexplored. This project aims to address this gap by integrating novel first-person methods from consciousness science, Micro-phenomenology and Temporal Experience Tracing, with objective neurophysiological data to better understand the experiential mechanisms behind SSM in insomnia, narcolepsy, and healthy controls. We will investigate SSM at three critical levels: 1) during the shift from wakefulness to sleep, using polysomnography and micro-phenomenology to identify the minimal requirements for feeling asleep and strategies developed by sleep disorder patients to facilitate/resist this transition; 2) during morning retrospective evaluation of sleep, using Temporal Experience Tracing to capture the dynamics of how sleep experiences are remembered and evaluated across a night of sleep, and its impact on morning fatigue; and 3) across multiple nights, to assess how day-to-day fluctuations in daytime cognition (mind-wandering, tiredness) and nighttime cognition (dreams) relates to SSM and mental health, using a 2-week protocol with actigraphy. This project has the potential to reveal key experiential dimensions related to SSM that have been overlooked, as well as a better knowledge of how SSM fluctuates over many days, which could lead to better evaluation tools or more personalized treatments for patients with sleep disorders.

Keywords: sleep disorders,sleep state misperception,insomnia,narcolepsy,phenomenology,neuroscience,consciousness,dreaming
Phase Separation in Metallic Glasses: Design, Phase Stability and Properties (PSMGDPP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 1
Project status: CLOSED

In recent years, much attention has been given to phase separated metallic glasses (MGs) which provide a unique opportunity for designing composites or alloys with hierarchical microstructure at different length scales. The structure and physical properties of phase separated MGs have characteristics different from those of other MGs. Many theoretical efforts have been undertaken to understand the origin of phase separation in MGs; yet the understanding of the mechanism is insufficient. This project aims to synthesize new MGs by alloying addition, aiming to understand the genesis of phase separation. The effect of alloying addition on phase separation and properties will be investigated. Such studies will help to understand the structure (microstructure)-property co-relations. The results of these investigations will be used as a guideline to modify the synthesis process to accomplish the main objectives, namely to obtain materials with desired properties. Novel glassy-nanocrystalline dual-phase MGs with high toughness and ductility will be designed that will provide an important insight for industrial application. In addition, we will explore the possibility of fabricating nano-porous foams and nano-filters in MGs. The nano-porous network structure in phase separating MGs has potential to be applied for many engineering applications. The project will be conducted at Erich Schmid Institute of Materials Science of the Austrian Academy of Sciences (ESIÖAW) under Prof. Jürgen Eckert’s supervision. ESI-ÖAW has internationally-leading expertise in the associated areas and Prof. Eckert is one of the world’s leading scientists in MGs and nanostructured materials. Based on the high reputation of the host and the strong track record of the applicant, it is believed that this research will bring a significant impact for Europe to have a leading position in science, and for the host and applicant to have an excellent career development.

Keywords: metallic glass phase separation nanocomposite microstructure structure property atomic cluster