Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
NEutron Spectrometry to Prevent Illicit Nuclear Trafficking (NESPINT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Italy
Call: Engaging SMEs in security research and development (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project aims at developing an innovative detector capable of playing a fundamental role in detecting illicit trafficking of nuclear materials across international borders. This detector, called NESPINT (Neutron Spectrometry to Prevent Illicit Nuclear Trafficking), will be constituted by a neutron spectrometer that passively interrogate items in the framework of port, airport and border security screening procedures. The project is expected to develop an industrialised version of NESPINT, tested in operational workplaces and ready for the market, to be implemented in different systems employed for security screenings. NESPINT will enter the business of detectors employed for homeland security, which is constantly increasing especially for what concerns illegal trafficking. Indeed, at the state of the art there are no commercial detectors that can compete with the characteristics of NESPINT, neither in terms of performance and efficiency, nor in terms of price and ease of use. NESPINT will satisfy the needs of the users involved in the homeland security market, as it will be characterised by fast and precise measurements, ease of use and reduced cost. The feasibility assessment to be carried out in phase 1 will be aimed at: elaborating a clear, measureable and realistic business plan; precisely determining the budget requirements for the funding request to be submitted during phase 2; precisely determining the total and the serviceable available market, split in the submarkets (airports, ports and others); finding potentially interested partners for phase 2; defining the national and international applicable standards to be respected for bringing NESPINT on the market.

Keywords: neutron spectrometry,illicit trafficking,he3 alternatives,special nuclear materials
TO MAKE THE INFORMATION UNDERSTANDABLE FOR EVERYONE (Capito)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Comprehensible information is the key to participate in society. If people do not understand, what’s going on around them, they are not able to make their own informed decisions. 54% of adults in the world population, people with learning difficulties and disabilities and immigrants are struggling to understand every information they take if it comes complexity level in B2, C1 and C2. Alongside negative social impacts, the cost of illiteracy in the global economy is more than €1.1 trillion annually. Capito is a mobile application which translates any complex information to three easy to understandable language level, A1, A2 and B1 in German, English, Portuguese and Spanish. Our aim as a social impact company is to create a society where everybody can have the same conditions. Our business model is based on three side app which includes end-users, customers and social franchise network. The application is serving to the end-user free, but we charge our customers and franchise network partners according to the service that we provide. End-users benefit from the barrier-free information and this allows them to live an equal environment with equal opportunities. For the companies and public authorities, they are able to make their products, services more understandable, and they do not need to serve additional support. The partners in a Franchise network get the same products and services in high quality from all their network partners. Additionally, automated transformation service is cheaper, time saver opposite to manual service. We, CFS GmbH want to secure the profitability for continuing growth and future competitiveness with the automated translating service. Until 2026, we assume a sustained increase of clients through our franchises from the target markets up to 800 clients and we will generate €20.131.448 as total revenue. Besides, we will have 24 new staff for technical and commercial duties whose 20% will be disabled people.

Keywords: a rule based approach,a statistics based approach,neural networks
Building Resilience through Education (BRTE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland,Ireland,Ethiopia,Ireland,Belgium
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2017-11-01
End date: 2022-12-31
Duration (months): 62.0
Total project cost (EUR): 2097000.0
EU funding (EUR): 2097000.0
Participants: 7
Project status: CLOSED

The Building Resilience Through Education (BRTE) Consortium brings together partners from academia, the private sector and the NGO sector to find innovative ways to strengthen the resilience of communities affected by recurring disasters. This project has its origins in an ex-post impact evaluation of Concern Worldwide’s twenty-five year engagement in Wolaita, Ethiopia. Conducted by University College Dublin’s Centre for Humanitarian Action in collaboration with Wolaita Sodo University, the evaluation found that, despite significant improvements in communities’ capacities to both absorb the effects of recurring disasters and to adapt their livelihoods based on experience of recent disasters, they remain extremely vulnerable to their natural and environmental context. As a result there is an urgent need for a novel approach that moves beyond supporting the mere absorption of or adaptation to recurring shocks and that transforms the capacity of exposed communities. The BRTE partnership has identified the importance of education in bringing about this transformative change. It aim is to build the capacity of Wolaita’s educational institution in pursuit of the following objectives: • To build the requisite critical infrastructure to enable resilience education and research; • To establish an educational platform that will build human capital and transform livelihoods; • To develop research and innovation capacity that will radically promote social and economic well-being. The BRTE programme will serve as a model of how education can drive transformative resilience in areas subject to recurring and protracted crises.

Keywords: recurrent crisis,educational capacity building,resilience,development
Enhancing Ultrasound and PHOtoacoustics for Recognition of Intestinal Abnormalities (EUPHORIA)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Germany,Ireland,Germany,France,United Kingdom
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2018)
Start date: 2019-01-01
End date: 2022-06-30
Duration (months): 42.0
Total project cost (EUR): 3406968.72
EU funding (EUR): 2314315.13
Participants: 5
Project status: CLOSED

EUPHORIA will pave the way to establish MSOT (Multispectral Optoacoustic Tomography) technology for the non-invasive assessment of intestinal inflammation in patients. EUPHORIA will enable commercialization of the technology by finalizing technical improvements that will increase diagnostic outcome beyond what has been shown in a first feasibility study, will improve usability, prepare CE marking for the new device and validate clinical results in a large clinical study. Inflammatory bowel disease (IBD) is a chronic condition, posing significant burden to patients and health care systems. Patients suffer from a relapsing course of intestinal inflammation, and to date, there is no satisfying non-invasive diagnostic modality for monitoring disease activity. In a recent clinical study conducted by University Hospital Erlangen, MSOT, a technology developed by iThera Medical (ITM), has proven to be superior in diagnostic performance to other procedures. Imasonic (IMA) and RayFos (RFO) are ideally positioned to drive the technical improvement steps: Imasonic, an expert in ultrasound transducer manufacturing, will develop an ultrasound detector with higher signal-to-noise ratio to enable better sensitivity and detection at depth. RayFos specializes on real-time sensing and image inversion, processing and rendering and has significant experience in optoacoustic tomography algorithms and implementation. iThera Medical will lead the incorporation into the device, CE marking and commercialization. The University Hospital Erlangen is an excellence center in IBD and will drive the clinical validation. Pintail has extensive project management, dissemination and commercialization expertise.

Keywords: optoacoustics,photoacoustics,ultrasound,chronic disease management,morbus crohn,colitis ulcerosa,inflammatory bowel disease
Normothermic perfusion devices for renal and hepatic preservation and viability assessment (NORMOPERF)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Spain
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-05-01
End date: 2016-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Organ transplantation is the best available technique for the treatment of end-stage failure of most essential organs. However, the further development of transplantation is being hampered by the scarcity of available organs and the limitations of static cold preservation: lack of information about the organ function and viability, ischemia-reperfusion injury, short preservation times and poor compatibility with suboptimal organs. Our solution to overcome these limitations consists in a portable medical device that is capable of maintaining the human kidney or liver in a viable state for sustained periods under physiological conditions ex vivo by means of a normothermic perfusion of the organ with a preservation solution that delivers oxygen, nutrients and chemical signals. Through maintaining the physiological cellular metabolism, it is possible to prolong the preservation times, reduce to a minimum ischemia-reperfusion injury, assess the organ viability and function by means of monitoring key parameters and increase the number of available organs. Our envisaged final solution consists in a product with three elements: the perfusion machine and two single-use consumables: the perfusion circuit and the preservation solution. Specific versions of the consumables will be available for each organ type (liver or kidney), but all of them will be compatible with the same perfusion machine. The product will address a global market, focusing initially on the EU and in a second phase on the USA. EBERS has a fully functional prototype of the device, validated and demonstrated using a porcine transplant model. In Phase 1 of the project, IP and regulatory strategies will be refined, the product concept will be validated, further market knowledge will be gained and the commercialisation plan will be detailed. In Phase 2, the prototype will be industrialised, a clinical assay will be performed and the device will receive CE-mark approval, becoming a market ready product.

Keywords: organ transplantation,normothermic preservation,kidney,liver,machine perfusion,viability assessment,decision support system
Functional genomics of non-coding mutations in regulatory regions of four metabolic tissues, and their involvement into type 2 diabetes through large-scale sequencing (Reg-Seq)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-05-01
End date: 2022-04-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Type 2 diabetes (T2D) is a complex systemic metabolic disorder which has developed into a global major health problem responsible for early morbidities and mortality. T2D is a multifactorial disease, resulting from progressive alteration of insulin secretion from beta cells in pancreatic islets, on a background of resistance to insulin action in various organs and tissues, including liver, skeletal muscle and adipose tissue. T2D heritability is estimated around 40-70%. Genome-wide association studies identified more than 90 T2D-associated common variants, but altogether they explain less than 15% of T2D inheritance. Rare loss-of-function coding variants may contribute to T2D risk. Moreover, recent studies suggested the putative impact on T2D risk of functional non-coding variants within active enhancers of pancreatic islets; but tissue-specific regulatory regions have remained largely unexplored by genetic epidemiology studies. I intend to make progress in T2D genetic epidemiology and physiology by extending genetic investigation to frequent and rare mutations in non-coding regulatory regions on a whole-genome basis. In the Reg-Seq project, I propose the next-generation sequencing (NGS) of most relevant DNA regulatory sequences of four key metabolic tissues for T2D (pancreatic islets, liver, muscle and adipose tissue) in large well-phenotyped prospective populations (N=10,000 samples), followed by a replication in additional cohorts and by comprehensive functional experiments when genetic associations are identified. This project should lead to the identification of new functional genetic markers and pathways involved in T2D risk and development, and should help to stratify the T2D population for precision medicine, which is one of the major goals of the EU-Horizon 2020 programme. Further elucidation of the missing heritability should enable a major advance in the prediction of T2D risk, which is still very poor for a genuine clinical translation.

Keywords: type 2 diabetes,genetics
Fake news and pseudo-science as post-modern mythology: The case of the anti-vaccination movement (FAKEOLOGY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Switzerland,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2023-01-06
Duration (months): 36.0
Total project cost (EUR): 278840.64
EU funding (EUR): 278840.64
Participants: 2
Project status: CLOSED

FAKEOLOGY draws links between pseudoscience, populism and health literacy and focuses on the anti-vaccination movement to provide a key venue wherein mis- and dis-information can be studied. Specifically, the project studies how pseudo-scientific news is diffused within social networks and how it affects human judgement and behaviour. FAKEOLOGY aims at enhancing the efficiency of science communication and at empowering public health policy makers to introduce fake-proof health literacy initiatives. Bridging large-scale social media data with news media (network analysis, content and discourse analysis) and behavioural data (focus groups, expert interviews, lab experiment), the project focuses on how pseudo-science propagates within the digital media ecosystem. Pseudoscience, and, specifically, the anti-vaccination movement, demonstrate a unique case study that indicates the longevity of the ‘fake news phenomenon’ as anti-vaccine myths started spreading decades ago and still feed the movement’s narrative. The popularity of vaccine hesitancy is growing, in spite of the scientific data that systematically debunk its claims, resulting in the resurgence of vaccine-preventable diseases. Within the digital terrain, anti-vaccination groups have even grown in visibility and volume and research demonstrates that Twitter constitutes a popular platform for anti-vaccination supporters. Using state-of-the-art media analytics technologies developed by the MIT Media Lab and building on science communication developed at the University of Zurich, the project contributes to cutting-edge research with an analytic model that can be fine-tuned to study veracity and falsity in the digital networked paradigm.

Keywords: fake news,pseudoscience,anti vaccination movement,social networks,network theory,discourse analysis,focus groups,ethnography,human judgement
Collaboration for Prevention and Treatment of MDR Bacterial Infections (COMBINE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Germany,Germany,Germany,Germany,Belgium,Belgium,Sweden,France,United Kingdom,Denmark
Call: AMR Accelerator programme Pillar A: Capability Building Network to accelerate and validate scientific discoveries (H2020-JTI-IMI2-2018-15-two-stage, 2018)
Start date: 2019-11-01
End date: 2025-10-31
Duration (months): 72.0
Total project cost (EUR): 25460100.0
EU funding (EUR): 8000000.0
Participants: 11
Project status: SIGNED

The loss of antibiotic effectiveness due to increasing antimicrobial resistance (AMR) is a serious threat to global public health. The IMI2 AMR Accelerator will develop new agents to treat and prevent infections caused by MDR and XDR bacteria, including Mycobacterium tuberculosis and non-tuberculous mycobacteria. The COMBINE proposal addresses Pillar A, the Capability Building Network (CBN) of the AMR Accelerator programme. The COMBINE consortium will form a Coordination and Support Office (CSO) that will support the delivery of projects across the AMR Accelerator, as well as with efficient communication among projects of the Accelerator and within the AMR community. In addition, we will establish an IT infrastructure that will allow for the FAIRification, collection, aggregation, storage, sharing, and analysis of vaccine and antibacterial preclinical and clinical data sets. When setting up the CSO, we will build on learnings from the two IMI ND4BB projects: ENABLE (an antibacterial discovery and development engine) and TRANSLOCATION (which has built an information centre for data sharing). COMBINE partners will work to accelerate scientific discoveries in the AMR field by optimisation and standardisation of animal infection models, and development of improved models for translation of preclinical animal efficacy data and statistical analysis of clinical data. This will set new standards for the translational and predictive relevance of preclinical data and facilitate optimized design for new clinical trials. Results will feed into study and trial design throughout the AMR Accelerator to achieve more stringent and reliable development programmes.

Keywords: antibacterials,drug discovery and development,clinical trial design and analysis,animal infection models
The obesity spiral: inflammation and effortless fast food choices (OBESITY_SPIRAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Obesity is a major threat to human health, often characterized by increased consumption of energy-dense and easy-to-eat, ‘effortless fast food’. A better understanding of effort-related motivation in obesity is important to explain why healthy lifestyle changes are often so hard to maintain. Previously, I have demonstrated the neurocognitive and neurochemical processes underlying motivational control of behaviour. However, in obesity, findings about the motivation to overcome effort costs for food reward – and associated dopamine signalling - are inconsistent, suggesting another – yet unknown - variable. Here, I am the first to suggest that this variable is chronic low-grade inflammation - as a direct result of excess body fat. Peripheral inflammation can affect the brain dopamine system to decrease effortful behaviour, enforcing the downwards spiral of obesity. However, how an elevated inflammatory tone in obesity relates to effort-based decision-making is currently unknown. Here, I aim to elucidate the neurocognitive mechanisms underlying effort-based decision-making in human obesity and the explanatory role of inflammation, using both an observational and a supplementation design with the anti-inflammatory aspirin-like drug salsalate. Moreover, I will determine the causal role of dopamine in effort-based decision-making in obesity by employing acute administration of the dopamine precursor levodopa, and I will study levodopa’s effects as a function of inflammatory tone. I will develop a novel fMRI paradigm that dissociates food reward anticipation, reward sensitivity versus effort avoidance during effort decision, effort exertion and reward consumption. Lab findings will be translated to real life with experience sampling methods. This innovative, interdisciplinary approach will elucidate the inflammation-effort link in obesity and explain inconsistent findings about dopamine abnormalities and effortful behaviour in obesity.

Keywords: obesity,fmri,inflammation,effort,reward,dopamine