Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Local and global geometry of moduli spaces of p-adic Galois representations (LGModGal)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

The Langlands correspondence is a series of mathematical predictions describing a deep relationship between two fundamental branches of mathematics: discrete mathematics, which is the basis of counting and number theory, and continuous mathematics, which underlies analysis. These connections are incredibly powerful and have helped solve some of the most challenging problems in mathematics, such as Fermat's Last Theorem, which remained unsolved for nearly 400 years. Despite significant advances over the past 30 years, much of this area remains unexplored. Recently, a new approach has emerged with the potential to revolutionise our understanding of the Langlands correspondence. The expectation is that this correspondence can be achieved via an interpretation of the analytic side as functions on geometric spaces which are built from basic objects on the discrete side—specifically symmetries of solutions to polynomial equations like Y²=X³+X+1. While it is speculated that this viewpoint will substantially simplify the problem, it is presently unclear how exactly these ideas should be implemented. A major issue is that the underlying geometry of these spaces are hard to control, rendering a precise interpretation as functions difficult. My research has hinted that, through innovative combinations of techniques from algebraic geometry and representation theory, taming this geometry is within reach. In this project I will develop these ideas to produce a general framework which controls these spaces. Consequently, foundational results in the Langlands correspondence, currently limited to dimension 2, will be developed in higher dimensions, making inroads into one of the most important and enduring problems of modern number theory.

Keywords: p adic langlands correspondence,p adic hodge theory,representation theory
BioPesTY: Safe and eco-friendly biopesticides made by yeast fermentation (BioPesTY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: SIGNED

Chemical pesticides pose significant threats to human health and biodiversity, causing millions of poisonings and deaths annually, along with a potential 40% decline in insect species. To mitigate these hazards, the European Commission has committed to reduce the use of chemical pesticides by 50% by 2030. Biopesticides, such as pyrethrins, offer a safe and effective alternative towards this direction. Pyrethrins are natural, biodegradable compounds with potent insecticidal properties produced by Tanacetum cinerariifolium plant (Dalmatian chrysanthemum). As they are safe for humans, and rapidly degrade into non-toxic byproducts, they are approved already for organic agriculture. However, pyrethrin industrial production occurs via plant cultivation and extraction, therefore, faces restrictions due to limited availability of land, labor-intensive cultivation, and environmental factors. Scaling up production is challenging, and total chemical synthesis is unsustainable. Biotechnological production of pyrethrins using baker’s yeast offers a sustainable solution. To achieve this, in BioPesTY, I will develop a yeast strain engineered to produce pyrethrins in a scalable and sustainable manner. Using a multidisciplinary approach engaging biochemistry, transcriptomics, and synthetic biology principles, I will identify the only missing step of pyrethrin biosynthesis, and I will reconstruct the whole pathway in yest, able to convert simple sugar into human-safe biopesticides. In BioPesTY I will enrich my current knowledge on plant biochemistry, with the training I will receive in the host lab on metabolic and yeast genetic engineering, and synthetic biology, to acquire unique expertise that will prompt me to develop my own scientific niche. During BioPesTY I will be trained also in fundraising, research management, communication, teaching and academic leadership. These skills will be instrumental in launching my future independent internationally competitive research career.

Keywords: metabolic engineering,plant specialized metabolism,synthetic biology
Criminal Life-Course Trajectories Globally (CRIMLIFE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Norway,Türkiye,Czechia,Nigeria,India
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2492420.0
EU funding (EUR): 2492420.0
Participants: 6
Project status: SIGNED

How do social contexts determine paths into crime? How do these trajectories vary across different societal circumstances? And how are they narrated? CRIMEGLO is the first-ever large-scale comparative life-course criminological study globally. No research hitherto has addressed criminal careers and storytelling in such detail and on the scale envisaged in this project. The approach will counterweight the current Northern bias in research and theory, a shift necessary to establish a truly global perspective within life-course criminology. Cultural and societal contexts play a large role in defining and responding to crime. Social conditions shape the life-courses of those getting caught up in the criminal justice system. Context is also intertwined with the ways people talk about their lives. CRIMEGLO will explore and compare crime from a life-course and life-story perspective spanning four continents and six countries: Norway, the Czech Republic, Türkiye, Nigeria, Bangladesh, and Colombia. By combining criminological theory with institutional, cultural, and narrative studies, CRIMEGLO’s goal is to establish global comparative research on crime within a life-course perspective. The primary objective is to introduce and theoretically develop a contextually sensitive, comparative global life-course criminology. The secondary objective is to achieve a better empirical understanding of the particular social, economic, institutional, and gendered factors shaping criminal life-courses in different countries with highly divergent societal contexts. Principal Investigator Sveinung Sandberg is a sociologist and one of Europe’s leading qualitative criminologists. He has pioneered the prominent research traditions of Bourdieusian Criminology and Narrative Criminology. With CRIMEGLO, he expands globally his qualitative work on life-courses and life-stories started in Latin America and, for the first time, incorporates quantitative and comparative methods to his research.

Keywords: sociology,criminology,narrative criminology,life course analysis,life history analysis,crime
Mechanism, Regulation and Functions of DNA Loop Extrusion by SMC complexes (LoopSMC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Life and evolution of organisms relies on the maintenance, integration, propagation, and readout of genetic information. This information is stored in chromosomes that have a specific three-dimensional structure, a condensed yet accessible form of DNA that is dynamically folded during the lifespan of cells. How DNA is folded within chromosomes has however remained a mystery. It has been proposed that this is achieved by a process of loop extrusion in which SMC (Structural Maintenance of Chromosomes) complexes that are multi-subunit ATPases present in all kingdoms of life – including condensin and cohesin – reel DNA into loops, thereby organizing genomic DNA into higher-order structures. Recent in vitro single-molecule studies, stimulated by our initial discovery on condensin, provided direct evidences that both condensin and cohesin can indeed generate chromatin loops by extrusion. However, the most fundamental questions relating to this process remain unanswered: What is the molecular mechanism of loop extrusion? How is this process regulated? What are the functional roles of SMC-mediated loop extrusion beyond condensation? To address these questions, we will synergistically combine our single-molecule loop extrusion assay with correlative light and electron tomography and force spectroscopy to reveal both dynamic and structural aspects of loop extrusion and SMC proteins. Specifically, we will resolve how SMC complexes function as molecular ‘motors’, how regulatory factors modulate the kinetics of loop extrusion, and how loop extrusion impacts cellular functions like chromosome segregation and gene recombination, all at the single molecule level. In the long term, our findings will provide vital insights into the basic packaging structure of the genome which directly governs its biological function.

Keywords: genome organization,single molecule biophysics,dna protein interactions
Democratic Administration under Illiberal Rule: Impact, Resistance, Resilience (LIBRAD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2422908.0
EU funding (EUR): 2422908.0
Participants: 1
Project status: SIGNED

LIBRAD investigates how populists in government reshape executive governance to implement illiberal policy changes. By covertly manipulating the machinery of government, populists erode pluralistic standards, reduce accountability, and politicize the civil service to advance their illiberal agenda. Bureaucrats play a crucial role in this context. Populists both fear them as potential saboteurs of their ambitions and simultaneously need to rely on them to push their agenda. To systematically examine the role of democratic bureaucracies when populists attempt to undermine liberal policymaking, LIBRAD analyses the performance and governance of populist governments at the subnational level in the European Union across areas such as health, education, law enforcement, and migration. It identifies how populists transform government organizations using a novel executive governance framework, advances an innovative group-based theory of bureaucratic behaviour in morally complex situations, and develops a new interactionist perspective on civil service ethics. By empirically examining populist rule at the subnational level in EU member states and analysing executive transformations in a selected subsample, LIBRAD seeks to understand when bureaucrats resist to or comply with illiberal demands. The project combines theory testing on the impact of populist rule with theory generation, providing a new interactionist explanation for bureaucratic behaviour. Additionally, LIBRAD will offer practical recommendations to increase administrative resilience against illiberal state deformations and provide insights on enhancing democratic legitimacy through executive organizational reform.

Keywords: public administration,democratic backsliding,populism,illiberal rule,regional government,subnational governance,european union
Harnessing bacteria-driven interfacial dynamics for optimised soil drying (BACTODRY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 1498436.25
EU funding (EUR): 1498436.0
Participants: 1
Project status: SIGNED

Bacteria abound in the soil, contributing to major global geocycles and plant growth. Bioaugmentation, the stimulation or tuning of this natural microbiome to optimize its function for human gain, has recently been used with success to manipulate biological interactions. However, we lack the understanding of the impact of bacteria on the physics of soil that would be necessary to direct bioaugmentation toward abiotic goals such as limiting water loss to drying – one fifth of all water deposited on land is rapidly lost back to the atmosphere by this process. Using novel experimental and theoretical approaches, BACTODRY will bring bioaugmentation for reduced drying toward feasibility by harnessing the control bacteria exert on macroscale drying via alteration of the physico-chemistry of the numerous microscopic air–water interfaces in a drying porous soil. We will develop microfluidic devices capturing features of air–water interfaces at the scale of one to a few pores while giving unprecedented access to bacterial and interfacial dynamics at the microscale (WP1–2), and use them to gain quantitative insight into the bio-physico-chemical couplings that set fluid flows and evaporative rate. How these microscale relations upscale will be tested in granular column experiments, shedding light on interface dynamics in complex 3D structures (WP3). We will then develop an in situ selective chip for isolating natural bacteria that impact drying (WP4). Building on the insights gained in WP1–4, we will demonstrate how soil can be bioaugmented with bacteria selected from the environment to achieve reduced evaporative drying in the field (WP5). BACTODRY’s novel methods and insights will have far-reaching impacts on our understanding of natural surface-active molecules, the study of microbial life in unsaturated soil and its impact on natural cycles, and the development of novel bioaugmentation tools grounded in the biophysical coupling between microbial life and abiotic phase.

Keywords: bacterial biosurfactants and biopolymers capillary and interfacial flows marangoni dynamics of air water interfaces bacterial motility and dispersal soil drying and multiphase flows in porous media water dynamics in unsaturated soils bioaugmentation
Life Saving Technology for Thoracic Trauma Treatment and Post Operative Drainage (C-LANT Drainage Port)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-03-01
End date: 2025-11-30
Duration (months): 33.0
Total project cost (EUR): 3571250.0
EU funding (EUR): 2499875.0
Participants: 1
Project status: SIGNED

Thoracic trauma is the 1st cause of accidental death globally, with a mortality rate of 60% in polytraumatic patients. The time of treatment is crucial. 80% of patients can be potentially saved if they are treated in 1h. However, current solutions to treat it are limited and static for the last 30-50 years. C-LANT is a unique self-fixating, a-traumatic and multifunctional device tackling this unmet need by offering a safe, fast, easy to use, multifunctional and cost-effective tool for treating any type of chest trauma or postoperative drainage following major thoracic and abdominal procedures. It reduces the procedure time by 20x and saves up to €2.6Bn associated with additional tube replacement (EU). With the EIC support Vigor aims to accelerate the clinical validation and scaling-up of C-LANT, providing a global impact to healthcare systems, clinicians, and patients. C-LANT will be part of the growing Emergency Medical Devices and the Surgical Drains markets (total valued >40B -2030)

Keywords: thoracic trauma,chest tube,pulmonary care,thoracic surgery,abdominal drainage,chest trauma,drainage,lung diseases
Precision-Adjustable Single-System Decision-Making (PASS-DM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-11-30
Duration (months): 27.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

Much contemporary research on decision-making purports that the brain has two distinct systems which can be used: model-free or model-based. Model-free allows for fast and automatic choices, but with a higher likelihood of errors. Model-based allows for context-specific adaptability, but with greater cognitive computational costs. In contrast to the prominent accounts of model-based vs model-free decision-making, I propose that the brain has a single decision system, which can be tuned to be more or less precise by investing more or less cognitive resources. The degree of precision determines whether the system appears to be more "model-free" or more "model-based" for any given decision. If successful, this project will play a critical role in redirecting a large sub-field of important decision-making (and learning) research. If unsuccessful, this project will provide powerful evidence that the current paradigm is correct.

Keywords: confidence certainty cost benefit tradeoff subjective value mental effort simulation memory attention
sub-Saharan Africa Health Research and Innovation Fellowship Program (SAHRI Fellowship Program) (SAHRI-Fellowship)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Coordination and support actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Belgium,Tanzania, United Republic of,Uganda,Rwanda,Ethiopia,Kenya,Germany,Burkina Faso
Call: Global Health EDCTP3 JU training fellowship with return phase (HORIZON-JU-GH-EDCTP3-2024-02-two-stage, 2024)
Start date: 2025-08-01
End date: 2030-07-31
Duration (months): 60.0
Total project cost (EUR): 4471197.45
EU funding (EUR): 3499947.45
Participants: 10
Project status: SIGNED

The SAHRI Fellowship Program addresses critical gaps in health research and innovation in sub-Saharan Africa (sSA) by developing a new generation of skilled researchers. This partnership joins African and European institutions, including members from the Eastern Africa Consortium for Clinical Research from Tanzania, Uganda, Ethiopia, Rwanda and Kenya, the Clinical Research Unit of Nanoro in Burkina Faso, the KU Leuven's (KUL) Access-To-Medicines Research Centre, and the Institute of Tropical Medicine in Antwerp, to collaborate with BioNTech SE. This unique fellowship program will train 12 promising researchers from sSA to become leaders in biomedical innovation and entrepreneurship, focusing on interventions against prevalent infectious diseases in the region. Fellows will complete a 24-months flexible 60 ECTS Master of Science in Tropical Medicine, a 6 ECTS course on Systems Thinking in Biotech development in KUL, engage in research projects at leading African institutions, and gain hands-on experience through industry internships with BioNTech. The program features a structured mentorship framework, pairing fellows with experienced mentors from academia, African research centres, and industry. A 12-month return-home phase enables fellows to apply their skills in local contexts, driving positive change and fostering sustainable partnerships. By expanding the pool of highly skilled researchers and innovators in sSA, SAHRI aims to enhance regional capacity for health research, promote South-South and North-South collaborations, and contribute to sSA's self-sufficiency in addressing its unique health challenges.

Keywords: training fellowship,research and development,pharmaceuticals,vaccines,infectious diseases,sub saharan africa
Developing of efficient and fossil free fire test methods and assessment protocols for the fire resistance of construction elements. (4FM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 2
Project status: CLOSED

The Marie Skłodowska-Curie Actions Green Charter guides all the researchers and the academic community to work towards a greener and better future. Therefore, the current action is appropriate and timely as it is primarily dependent on the reduction of the excessive amount of carbon footprints, generated through the huge number of fossil-based experiments conducted to observe the suitability of structural materials for different applications and denoting fire-ratings. The project will focus on introducing fossil-free electric heating (inductive/resistive) for different structural materials and compare the results to the established fossil-based ones. The aim being to prove that fossil-free methods can also help in providing the required information on different structural materials, resulting in possible standardisation of the same. Acceptance and proper functioning of the method will substantially help in reducing the use of fossils, specifically propane, and in working towards a more sustainable environment. Furthermore, the process will also enable in providing a portable and economical way for research institutes and universities to conduct large-scale experiments on new structural materials. The action will also involve the specification of a method to achieve optimal desired fire-safety in materials, and a renewable wood-based structural composite material that has good mechanical and fire performances. The successful preparation, testing and analysis of the new structural material will further enable the team to file a patent. Additionally, the same material will be used to prepare corrugated and honeycomb sandwiched structures with numerical modelling, that for the first time will capture the influence of the cell sizes on the flammability of the structure.

Keywords: fire,fire resistance,sustainable materials,sustainable buildings