Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Improved CarbOn cycle represeNtation through multi-sCale models and Earth obseRvation for Terrestrial ecOsystems (CONCERTO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Italy,Austria,United Kingdom,Spain,Belgium,Netherlands,Bulgaria
Call: Quantification of the role of key terrestrial ecosystems in the carbon cycle and related climate effects (HORIZON-CL5-2024-D1-01, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 9874252.5
EU funding (EUR): 9874252.5
Participants: 13
Project status: SIGNED

Earth system models (ESM) show diverging estimates of ecosystem carbon (C) uptake which drives persistent uncertainty about future climate and limits the realization of policy mitigation goals. The CONCERTO project aims to strengthen the European research ecosystem by creating an innovative scientific collaborative framework that enhances our understanding, monitoring, and modelling of the terrestrial cycle (CC), and leads to reduced uncertainty and ESM convergence. This framework has three main elements: the exploitation of novel Earth Observation (EO) data, the innovation of process models fed by these data, and Data Assimilation (DA) and Machine Learning (ML) techniques. The consortium includes European experts and institutes active in these areas. CONCERTO will advance the representation of land cover, leaf area index (LAI) and management intensity through new maps of high resolution with layers relevant for the CC. The new management map will enhance the creation of a new biomass production map. Further, CONCERTO will prepare for the ingestion of FLEX data in land surface models (LSM) through DA, and exploit Sentinel-5P/TROPOMI HCHO indicative of biogenic volatile organic compound (VOC) emissions. As step towards moving away from prior (static) parameterizations, the novel P model will be used to ingest these new data sources. This will enhance understanding of ecosystems responses to climate extremes, fires, and vegetation recovery from them, and the parameterization of LSMs included in ESMs. Novel representations of the underrepresented processes of lateral carbon fluxes through outgassing of CO2 from rivers will be developed. Dedicated seasonal and climate experiments will demonstrate how improved representation of land surface processes benefit the accuracy and trustworthiness of global Earth System simulation. This will lead to better predictability of the influence of land management on the CC and underpin avenues towards carbon neutrality

Keywords: land cover use,management intensity,biomass productivity,model complexity,land surface models earth system models,vocs,carbon water cycle coupling,climate extremes,fires
Cmos cOmpatible optoelectroNic deviCEs PlaTform for 2d-materials (CONCEPT-2D)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-10-31
Duration (months): 26.0
Total project cost (EUR): 182596.14
EU funding (EUR): 182596.14
Participants: 1
Project status: SIGNED

The need for inexpensive yet highly efficient optoelectronic devices such as LED/Laser/Photodetector/Solar Cells is driving the search for a new generation of semiconductors that have high absorbance in the visible, broad wavelength operation range, are transparent and flexible albeit with strong light-matter interaction, and are easy to process. Manufacturing these optoelectronic devices at a large scale involves concerns at technological, economical, ecological, social, and political levels. Ideally, the new materials are abundant, easily processed, and feature long term stability and non-toxicity. The advent of 2D transition metal dichalcogenides (TMDs). e.g., MoS2 and WS2, has generated great expectations since these materials fulfill all these requirements. 2D-TMDs exhibit direct band gaps, high absorption coefficients, and high carrier mobility values, making them promising candidates for optoelectronic applications. The out-of-plane quantum confinement responsible for the direct bandgap in the monolayer also allows for the modulation of the bandgap as a function of the number of layers. We propose the study of a large production of the 2D materials compatible with the CMOS industry. That pushes up the fabrication scale of the 2D material and make it compatible with the photonics integrated circuits (PICs) platform that nowadays are in the market. The co-integration of the PICs and 2D materials allows a new generation of devices, such as label-free biosensor with a small footprint, energy harvesting, room temperature quantum devices for computing and communication, and open the door to new quantum sensors.

Keywords: nano engineering,electronics,photonics,nanophysics,optical engineering,photonics
RNA Epithelial Approach for Crohn’s Treatment (RE-ACT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-06-01
End date: 2026-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

RE-ACT aims to translate groundbreaking ERC-funded research on lncRNA-based therapy for Crohn's Disease (CD) into a commercially viable treatment option. Our innovative approach targets the gut epithelial lining using lncRNA encapsulated in lipid nanoparticles (LNPs), addressing a critical gap in current CD treatments which primarily focus on immune suppression. By restoring epithelial function, we aim to achieve better mucosal healing and long-term patient outcomes. Building on our discovery of widespread lncRNA dysregulation in CD patients, we will conduct comprehensive preclinical studies to validate the efficacy and safety of our lncRNA-LNP therapy. Our work will involve both ex-vivo studies using human cell models and in-vivo studies in mouse models of epithelial injury and gut inflammation, focusing on optimizing delivery, assessing therapeutic effects, and evaluating potential systemic impacts. Concurrently, we will develop a robust IP strategy to protect our innovation, conduct thorough market assessments to understand the commercial landscape and engage in targeted business development activities to secure partnerships and funding for future clinical development. Our integrated approach combines scientific rigor with commercial acumen, maximizing the potential for successful translation from laboratory to clinic. The project addresses a significant unmet medical need in CD treatment, potentially offering a more effective and targeted therapy with fewer systemic side effects. If successful, our lncRNA-based approach could not only improve outcomes for CD patients but also pave the way for similar therapies in other gastrointestinal disorders. By combining cutting-edge science with strategic commercial development, this project represents a significant step towards addressing the limitations of current CD treatments and improving the lives of millions affected by this challenging condition.
Building Capacities for the Climate Neutral and Smart Cities Mission (CapaCITIES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Climate neutral and smart cities
Destination: Climate neutral and smart cities
Action type: Coordination and support actions
Countries involved: Romania,Austria,Hungary,Italy,Netherlands,Poland,Portugal,Spain,Sweden,Slovakia,Türkiye,Germany,Czechia,Finland,France,Greece,Norway
Call: Supporting national, regional and local authorities across Europe to prepare for the transition towards climate neutrality within cities (HORIZON-MISS-2021-CIT-01, 2021)
Start date: 2022-10-01
End date: 2025-03-31
Duration (months): 30.0
Total project cost (EUR): 1997952.0
EU funding (EUR): 1997951.0
Participants: 64
Project status: SIGNED

CapaCITIES will shape a European environment conducive to urban climate neutrality transitions for national, regional and local authorities. The project aims to initiate and strengthen national change processes by establishing national networks and governance structures and by providing dedicated support for public authorities to put enabling conditions and measures for cities in place for achieving the cities mission. To achieve this ambition, the CapaCITIES consortium represents 15 European countries who have committed to initiative and strengthen national change processes by ministerial or other high political level. CapaCITIES thereby build on a well-established network of national authorities (national ministries and agencies responsible for urban transition) with its relevant urban stakeholder organisations beyond the consortium partners and countries. To all project partners CapaCITIES offers dedicated services to in support of national change process. First, a transnational alliance for public authorities to exchange, learn and inspire each other in their transition towards climate neutral cities. Second, support in prototyping innovative multi-level and cross sector governance structures. Third, thematic capacity building for public authorities and support in taking effective local action and fourth, strategic synergies and access to other initiatives that address the climate neutral and smart cities mission.

Keywords: smart cities mission urban climate neutrality transitions national change processes innovative multi level and cross sector governance structures capacity building for public authorities
Global Knowledge Exchange Centre (GKEC) for Urban Climate Neutrality (GKEC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Climate neutral and smart cities
Destination: Climate neutral and smart cities
Action type: Coordination and support actions
Countries involved: Austria,Belgium,Germany,France,Denmark
Call: Global cooperation and exchange on urban climate neutrality (HORIZON-MISS-2021-CIT-02, 2021)
Start date: 2022-12-01
End date: 2025-11-30
Duration (months): 36.0
Total project cost (EUR): 1999909.38
EU funding (EUR): 1999907.0
Participants: 7
Project status: SIGNED

The ambition of the Global Knowledge Exchange Centre (GKEC) for Urban Climate Neutrality is to mainstream actions towards climate neutral and net-zero urban developments on a global level. In this sense, the GKEC will provide support in terms of global outreach for the European Cities Mission as well as contribute to the Urban Transition Mission of Mission Innovation. It will provide effective support and knowledge for local governments and international stakeholders and through this, support European policy such as the European Green Deal and work towards the international commitments of the Paris Agreement. The GKEC will make available evidence and good practice for urban climate neutral and net-zero transitions globally and facilitate capacity building, knowledge exchange and moderated learning for municipalities and key stakeholders. In operational terms, the GKEC will set up actions according to the three impact pathways: 1.Mainstream knowledge and good practice to accelerate urban transitions: The mission platform will be extended towards global use, making available international solutions and good practices and promote financing and funding opportunities to implement integrated urban climate action and net-zero pathways. 2.Offer advanced frameworks and moderated learning across all governance levels to raise awareness of and capacities for CN and NZ policies: Policy advocacy for climate neutral and net-zero approaches will allow aligning of global policies. Capacity building measures for local and regional actors will provide guidelines and support mutual learning to drive systemic change. 3.Establish the GKEC as a forum for international exchange and cooperation on climate neutral and net-zero transitions: Global and regional events accompanied by comprehensive dissemination measures will raise visibility of EU and international good practice and strengthen international cooperation on climate neutrality and net-zero pathways.

Keywords: urban climate neutrality,urban transitions,net zero pathways,global knowledge exchange,climate neutral cities mission
Longitudinal Educational Achievements: Reducing iNequalities (LEARN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Finland,Switzerland,United Kingdom,Germany,Italy,Romania,Estonia,Netherlands,Ireland
Call: Mapping of longitudinal data and assessment of inequalities in education, training and learning achievements (HORIZON-CL2-2023-TRANSFORMATIONS-01, 2023)
Start date: 2024-04-01
End date: 2027-03-31
Duration (months): 36.0
Total project cost (EUR): 2250187.2
EU funding (EUR): 2250187.2
Participants: 14
Project status: SIGNED

Europe is home to some of the most highly educated societies in the world. However, deep inequalities in education remain both within and between countries in Europe. Inequalities in learning outcomes, access to education and final educational attainment in Europe have been worsening and it is important to understand how socio-economic status, gender, ethnic and migrant status are associated with inequalities over the life-course. For this a longitudinal approach is needed and project LEARN (Longitudinal Educational Achievements: Reducing iNequalities) will highlight short-, medium- and long-term patterns of inequalities with a view to supporting educational policymaking in being able to robustly address these inequalities with interventions which are evidence based. Using a case study approach in nine carefully selected countries which capture the diversity of Europe’s education systems, LEARN will map and collect existing data providing original analysis of a range of high-quality education focused longitudinal educational data sets across Europe. LEARN will identify interventions that compensate educational inequalities by providing a synthesis of existing work across Europe examining specific trends in educational inequalities and interventions intended to reduce them. LEARN will then go on to develop tools for policymakers related to the findings of longitudinal analysis which support them in the policy making process. Through improving the evidence base for education policy making, the positive impact of LEARN is likely to be felt for decades to come.

Keywords: longitudinal,inequality,transitions,wellbeing,comparative
Generating mRNA-HNF4a-Lipid nanoparticles for curing pancreatic cancer-associated cachexia (CAC) in identified patients at risk (CACure)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-03-01
End date: 2024-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Cancer-associated cachexia (CAC) is a multifactorial syndrome causing significant morbidity and mortality in cancer patients and indicates a poor prognosis. Nearly 80% of cancer patients experience CAC, which directly accounts for almost 20% of all cancer deaths, mainly in patients with pancreatic adenocarcinoma (PDAC). Clinically, CAC manifests as weight loss and wasting of skeletal muscle mass. Thus, CAC patients experience reduced physical, emotional, and social well-being, leading to increased use of healthcare resources. The massive phenotypic manifestations point to a significant imbalance in the systemic metabolism of CAC patients. Unlike starvation, CAC cannot be reversed by standard nutritional interventions, and currently, there are no biomarkers for identifying patients at risk for CAC and no effective therapeutic modalities. With our ERC (#818943), we identified changes in liver metabolism during extra hepatic carcinogenesis. We now demonstrate that these metabolic changes occur early, precede CAC, and can be diagnosed by routine liver biochemical profile. We generated a biochemical liver score that can identify PDAC patients at risk for CAC, irrespective of disease stage at diagnosis. Furthermore, we find that these metabolic changes in the liver are mediated by early infiltrating immune cells that lead to HNF4a depletion in hepatocytes independent of liver metastasis. Importantly, we find that re-expressing HNF4a with Adeno Associated Virus (AAV8) preserves liver metabolism in PDAC mouse models and alleviates CAC. We hence hypothesize that generating liver-specific mRNA of HNF4a will be highly therapeutically beneficial for PDAC patients identified by our liver score to be at risk for CAC. In this PoC we will generate and test the efficiency of novel HNF4a-mRNA-LNPs in preventing or alleviating CAC in PDAC mouse models. When successful, our optimized construct will undoubtedly serve identified PDAC and other cancer patients at risk for CAC.
The energy-converting mechanism of a modular biomachine: Uniting structure and function to establish the engineering principles of respiratory complex I (ModularBioMachine)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: United Kingdom
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-04-01
End date: 2031-03-31
Duration (months): 60.0
Total project cost (EUR): 2444452.0
EU funding (EUR): 2444452.0
Participants: 1
Project status: SIGNED

Complex I (NADH:ubiquinone oxidoreductase), one of the largest membrane-bound enzymes in the mammalian cell, uses the reducing potential of NADH to drive protons across the inner mitochondrial membrane and power ATP synthesis. It is a keystone of metabolism, crucial for survival of human cells, and a primary site of mitochondrial dysfunctions and clinical disease. Complex I is also an efficient energy-converting biomachine, which shares conserved subunits, a molecular architecture, and modular design with prokaryotic type-4 hydrogenases, such as formate hydrogenlyase (FHL), that contribute to microbial H2 metabolism and geochemical cycles. Detailed cryo-electron microscopy (cryoEM) structures have defined the physical framework of the catalytic machinery in complex I, but there are wide knowledge gaps in central aspects of how it works, and no firm foundation of functional data to distinguish competing mechanistic proposals. ModularBioMachine will combine advanced strategies for structure, nanoassembly, function and genetics to transform knowledge of the reversible energy-transducing mechanism of complex I and FHL, exploiting their similarities and differences for enhanced insights and impact. It will exploit two powerful complex I platforms, complex I-containing proteoliposomes, which enable cryoEM under precisely defined conditions during energy-linked catalysis, and complex I from Paracoccus denitrificans, which combines cryoEM, genetics and advanced functional analyses in a single system – and extend both to study FHL. Focussing on three crucial knowledge gaps, the power stroke at the heart of energy conversion, the clockwork mechanism that defines the moving parts, and the proton wiring diagrams, ModularBioMachine will deliver a coherent, integrated understanding of the shared engineering principles and molecular mechanism of energy conversion in these evolutionary-linked biomachines at an intersection of the mitochondrial and microbial worlds.

Keywords: oxidative phosphorylation,electron transport chain,complex i,formate hydrogenlyase,cryoem,proteoliposome,enzyme mechanism,redox enzyme,proton pumping enzyme
New AntiVirals for Infections with Pandemic Potential (NAVIPP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Belgium,Sweden,Hungary,Austria,Netherlands,France,Spain,Germany,United Kingdom
Call: Pandemic preparedness and response: Broad spectrum anti-viral therapeutics for infectious diseases with epidemic potential (HORIZON-HLTH-2023-DISEASE-03, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 6170152.5
EU funding (EUR): 6170152.5
Participants: 12
Project status: SIGNED

For infectious disease management and control, vaccines are considered golden countermeasures. but are not the most adequate tool for mitigating the early effects of an outbreak. Taking the recent COVID-19 pandemic as an example, access to broadly applicable therapeutic antivirals would have had a major impact, decreasing the human toll of the disease, and alleviating the burden carried by health care systems. It is urgent to focus resources and efforts on the development of broad spectrum antiviral drugs against unknown pathogens. The NAVIPP consortium aims to strengthen the EU’s readiness and response capacity to viral threats by assembling an international R&D platform for antiviral drug development against pandemic prone pathogens. The consortium will implement a strategic, multi gear R&D and clinical roadmap for the identification, optimisation, preclinical and clinical investigation of broad spectrum antivirals against pathogens with epidemic or pandemic potential. In particular, the consortium will design compounds library with increased diversity to be tested in high-throughput assays against highly pathogenic viruses. Hits coming from this exercise, as well as assets that have demonstrated antiviral activity in previous exercises, will be assessed against a larger virus panel. Validation of the antiviral efficacy of the hits will be done in state-of-the art ex vivo models to prioritize compounds going to in vivo proof of concept studies. Mode of action and target will be also interrogated. Additionally, the implementation of an adaptive platform trial will enable early clinical investigation of 3 antivirals and will pave the way for clinical testing of other antivirals. Finally, the project will investigate new innovative and improved delivery systems of antivirals through nano conjugation. Ultimately, this project will deliver a pipeline of broad-spectrum anti-viral candidates and in the longer term contribute to European preparedness for emerging threats.

Keywords: drug development,broad sprectrum antivirals,epidemic and pandemic prone viruses