Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
VALORISATION OF CO2 WASTE STREAMS INTO POLYESTER FOR A SUSTAINABLE CIRCULAR TEXTILE INDUSTRY (THREADING-CO2)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Processes4Planet (co-programmed)
Countries involved: France,Belgium,Spain,Finland,Italy,Germany,Estonia
Call: Valorisation of CO/CO2 streams into added-value products of market interest (Processes4Planet Partnership) (IA) (HORIZON-CL4-2022-TWIN-TRANSITION-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 22463762.5
EU funding (EUR): 16740388.5
Participants: 13
Project status: SIGNED

The textile industry is the fourth largest industry in the world with the global volume of fiber production for textile manufacturing reaching 110 million metric tons in 2020. At the same time, the textile industry is one of the most polluting industries worldwide with the highest greenhouse gas (GHG) emissions corresponding to 10% of the global emissions. Polyester (PET) is the most widely used fibre in the industry, making up 52% of the global market volume. No technology available today is capable of addressing the textile industry’s sustainability and virgin PET produced from primary petrochemical sources remains predominant with a fossil fuel consumption of 98 Mt annually which is expected to reach 300 Mt by 2050. Addressing the key challenges of carbon neutrality, circularity, cost, value chain adaption, and textile properties is the ambition of Threading-CO2, a disruptive project that will demonstrate on an industrial scale a first-of-its-kind technology that converts CO2 waste streams into sustainable PET textiles. Threading-CO2 aims to scale-up and demonstrate its first-of-its-kind technology producing high-quality commercially viable sustainable PET textile products from CO2 waste streams at industrial scale (TRL7) using a circular manufacturing approach and running on renewable energy sources. The overall outcome of the Threading-CO2 project is a 70% GHG emissions reduction compared to existing PET manufacturing processes. In addition, Threading-CO2 will enable the creation of a European value chain for sustainable PET textiles, from feedstock to final textile products in the clothing, automotive and sports/outdoor industries.

Keywords: sustainable textile,co2 valorisation,recycled pet,polyester,alternative feedstocks,first of its kind technology,circular economy approach,recyclability,learning resources
Sophisticated Microbubble Coating Materials for Functional Ultrasound Sensing (MICOMAUS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1962500.0
EU funding (EUR): 1962500.0
Participants: 1
Project status: SIGNED

Lipid-coated microbubbles are fascinating objects rich in nonlinear dynamics. They are used in medicine as ultrasound contrast agents (UCAs) to visualize organ perfusion. The contrast enhancement results from their ultrasound-driven oscillations, which produce a powerful echo. The echo response is sensitive to ambient pressure and the microbubble surroundings so that bubbles have potential sensing capabilities that reach far beyond their current use as contrast agents. However, UCAs contain microbubbles non-uniform in size (1-10 μm diameter) and in shell properties. The resulting ill-defined echo inhibits game-changing applications such as non-invasive pressure sensing and molecular sensing using functionalized bubbles that bind to diseased cells. Microfluidics allows controlled formation of mono-sized bubbles. However, even the echo response of mono-sized bubbles is heterogeneous due to uncontrolled shell properties. I aim to go beyond size-control and enable the microfluidic formation of functional mono-acoustic bubbles with a tuned and predictable acoustic response. The challenge is to bridge the gaps between fluid dynamics, colloid and interface science, interface rheology, and acoustics to unravel the coupled problem of microfluidic bubble-shell formation and ultrasound-driven bubble dynamics in the bulk and near or targeted to a wall. To reach this goal, we will develop highly controlled lab experiments at the sub-microsecond and sub-micrometer level, together with simulations and theory development. The ultimate goal is a physics-based parametrization of the acoustic bubble response as a function of shell formulation, microfluidic control parameters, diffusive gas exchange effects, and targeted molecular binding of the bubble to a boundary.

Keywords: microfluidics,microbubbles,colloid and interface science,interface rheology,acoustics
Spatiotemporal characterization of extrachromosomal DNA transcription and its key regulators in cancer cells (FINDR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

Extrachromosomal circular DNA (ecDNA) present in cancer cells stochastically amplifies oncogenes and drug resistance genes independent from the core genome and thereby contributes to tumor adaptability and heterogeneity. While ecDNA prevalence, diversity, and biological traits have been studied, we lack insights into their expression regulation. It is unclear how it differs from chromosomal genes and how it is linked to the non-random and dynamic nuclear localization patterns observed for many ecDNA. Moreover, we are unaware of the proteins that participate in interactions with nuclear compartments to control ecDNA transcription. Most studies using sequencing and FISH methods fall short in describing these dynamic processes. However, understanding their implications is vital for designing therapies that target ecDNA expression as a whole instead of targeting individual oncogenes. To advance our knowledge, we need tools to map ecDNA transcription at high temporal and spatial resolution and systematic methods to screen for associated proteins. The aim of this project is to identify crucial overarching mechanisms and players of ecDNA transcription through an interdisciplinary approach. The Medema group has devised protocols to induce extrachromosomal amplification of drug resistance genes in diverse cellular backgrounds and genetically tag them for imaging and perturbation. The present study will build on this work to for the first time reveal the spatiotemporal co-regulation of ecDNA transcription and localization using innovative imaging reporters for measurements in single live cells and use unbiased proteomic profiling to map factors that interact with ecDNA and regulate their expression. Besides addressing outstanding questions in the field, our study will create unique cell models and datasets as a basis for future studies. Our results will furthermore inform the design of more effective treatments for the many cancer patients affected in Europe and worldwide.

Keywords: extrachromosomal dna,transcription regulation,live imaging,proteomics,cancer cell biology
The Mysterious Bang: A Language and Population Isolate Unlocks the Secrets of Interior West Africa's Lost Ethnolinguistic Diversity (BANG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 1966250.0
EU funding (EUR): 1966250.0
Participants: 1
Project status: SIGNED

Species are often the most diverse at their origins, and all modern humans can trace their origins back to Africa. Our ability to communicate through language defines us; every human being speaks (or signs) at least one language. We may never know when our current forms of language were first spoken, or what speakers sounded like, but we can be assured that primordial languages were spoken in Africa. Yet, a paradox presents itself with respect to the apparent lack of linguistic heterogeneity in Africa: the languages comprise only four of the world’s more than 150 families. Isolates, languages with no known living relatives, represent the missing links between today’s homogeneity and the past’s diversity. Bangime may represent the only confirmed language isolate spoken today in interior West Africa. Its speakers, the Bangande, have resisted genetic admixture with neighboring populations for upwards of 9.000 years. The root of their eponym [BANG], means ‘hidden’ or ‘secret’ in surrounding Dogon languages whose linguistic and genetic ancestors are almost as mysterious. ERC-BANG will search for evidence of contact or inheritance between Bangime and a hitherto unexplored set of West African languages and populations using computationally-supported methods. Our research team will conduct an in-depth study of culturally significant and historically relevant loan words, so that a statistician can incorporate these findings into stochastic models of language diffusion. A geneticist will process the entire Bangande genome to compare with West African populations from a wider range than thus far considered. Together, we will perform a character-based Bayesian phylogenetic analysis of the Dogon languages to estimate the time depth of the group in order to test settlement hypotheses and proposed migration patterns. Completion of this project will uncover traces of vanished ethnolinguistic varieties in West Africa, and our methods can be replicated to solve similar questions.

Keywords: language and population isolates computer supported approaches to historical linguistics language origins west africa
REVOLUTIONARY REFURBISHMENT FOR AN EFFICIENT AND ECO-FRIENDLY HYDROPOWER (RevHydro)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Sweden,France,Romania,Germany,Switzerland
Call: Development of hydropower equipment for improving techno-economic efficiency and equipment resilience in refurbishment situations (HORIZON-CL5-2024-D3-01, 2024)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 3999951.25
EU funding (EUR): 3999950.5
Participants: 10
Project status: SIGNED

The RevHydro project aims to enhance the efficiency, flexibility, and sustainability of existing hydropower plants through the design and validation of flow control devices. Specifically, the proposed flow control devices, located in the runner and draft tube, extend the operating range of turbines, reduce fatigue, and enhance overall efficacy. Notably, their installation will require minimal downtime, resulting in significantly improved refurbishment processes. Additionally, the project incorporates an innovative fish barrier and a circular design approach. The innovative fish barrier included in the project adapt to the incoming fish, allowing to redirect fishes to safe passages, contributing to environmental conservation efforts. Furthermore, the circular design approach adopted in the project allow at minimizing costs and environmental impact. This holistic approach ensures compliance with water quality standards and supports biodiversity conservation.
Shaping A Transition-metal coordination sphere to Unveil Routes uNmet in catalysis: main-group cations and iron triad metals (Fe, Co, Ni) as a starting kit (SATURN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 1964550.0
EU funding (EUR): 1964550.0
Participants: 1
Project status: SIGNED

Transition-metal (TM) catalysis is pivotal in organic synthesis, and led to spectacular breakthroughs in that field over the last fifty years. In particular, development of catalysts using non-noble metals from the “iron triad” (Fe, Co, Ni) keeps attracting a lot of efforts. This is due not only to their low cost and their abundance, but also to their incredibly diverse reactivity, thanks to a broad panel of oxidation states and coordination patterns. Still, the design of efficient Fe, Co or Ni catalysts proves to be tedious work, as their coordination sphere often requires drastic rearrangements along the reaction paths. To accommodate those events, next-generation catalysts have to display a high plasticity, and must overcome the paradigms of classic design of “static” ligand spheres, with no consideration of their dynamic evolution. The central idea of the SATURN project is to use external main-group Lewis acids to achieve a dynamic control of the composition of the TM coordination sphere, with a focus on Fe, Co and Ni chemistry. In a catalytic context, this original approach will i) unlock the formation of key intermediates and ii) drive their reactivity towards selective paths, providing new strategies in synthetic chemistry. The first work package (WP1) will establish the general guidelines of this approach, and show that main-group Lewis acids can modulate the coordination sphere of reactive TM compounds. Development of new catalytic 3-component couplings will validate this approach. To widen the application scope of this method, WP2 will enable the control of a single TM catalyst by different main-group Lewis acids, whose nature will selectively guide the system towards different E–H functionalization paths (E = C, Si, B, Ge). The last WP3 will show that this approach can also modulate the reactivity of redox-active catalysts, achieving a control of both TM and main-group oxidation states, leading to new strategies of alkyne difunctionalization.

Keywords: organometallic chemistry,non noble metals,main group cations,reaction mechanisms
Social Tipping Points in the Food System for Freshwater Sustainability (TIP-FRESH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 1470641.0
EU funding (EUR): 1470641.0
Participants: 1
Project status: SIGNED

The increasing global demand for farmland products is placing unprecedented pressure on the global agricultural system and its water resources. Landscape conversion for agriculture (of which 75% is used for livestock) and increasing irrigation demand (accounting 70% of global water withdrawals) are exacerbating water stress and groundwater depletion, while altering atmospheric moisture recycling (i.e., the process of water evaporating from land, flowing through the atmosphere, and falling out again as precipitation over land), which is vital for regulating the climate and the Earth’s system stability. To accelerate the food system transition toward sustainable diets, TIP-FRESH will pioneer a groundbreaking approach to reversing the freshwater crisis through social tipping points in the global food system. The concept of Social Tipping Points that this project exploits offers an opportunity to escape the current dominant food regime and spread the adoption of less water-intensive diets that have already been adopted in niches. Individual and collective dietary shifts can trigger cascading impacts across international trade networks and production systems, ultimately reshaping the way freshwater is consumed and preserved. By leveraging the concept of social tipping points, TIP-FRESH project will develop a novel framework integrating multidisciplinary approaches: mathematical tools will be employed to analyse dietary patterns and diagnose how tipping dynamics have manifested over past decades; hydrological modelling will provide a deeper understanding on the diets’ freshwater impacts by newly quantifying the hydrological repercussions of livestock-driven deforestation; and system dynamic model describing behavioural change will pave the way to sustainable diets and their potential to spread from niche behaviours to the dominant food regime through social networks.

Keywords: sustainable food system,social tipping points,freshwater sustainability
Scaling up early and late effects research in Lithuanian childhood cancer survivors through education and twinning (SCARLET)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Life Sciences
Countries involved: Lithuania,Germany,Denmark,Netherlands,Belgium
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 1499720.63
EU funding (EUR): 1499720.63
Participants: 6
Project status: SIGNED

The SCARLET (SCAling up early and late effects Research in Lithuanian childhood cancer survivors through Education and Twinning) proposal aims to increase scientific excellence and innovation capacity at Vilnius University Hospital Santaros Klinikos (VULSK) and its affiliated entity National Cancer Institute (NCI) by scaling up research activities in Lithuanian childhood cancer survivors (CCS). The area for twinning was defined based on the emerging importance of survivorship research due to the increasing number of CCS in Europe and identified gaps in Lithuania. The key challenges addressed in the proposal are 1) lack of data on the prevalence of CCS in Lithuania exploitable in research initiatives; 2) poor transition from paediatric to adult care depriving young CCS over the age of 18 of advantages of surveillance in a research context; 3) the need to implement innovative solutions for monitoring and prevention of early and late effects through joint research activities; 4) suboptimal competences in management and administration of large-scale research projects. Four research-intensive institutions from 4 European countries will bring to the consortium their specific expertise to address identified shortcomings. The proposal aims to build on and exploit current shared research initiatives that will be leveraged to achieve SCARLET’s goal and objectives. The twinning exercise will be implemented through secondments of Lithuanian staff to the partner premises and engagement in the research activities led by partner institutions, organisation of educational events, and participation in knowledge-of-transfer meetings. As a result of the twinning activities, VULSK and NCI will improve their research profile and reputation, international visibility, and attractiveness. The expanded networking channels will facilitate Lithuanian professionals to join international research groups focused on survivorship research ultimately improving the quality of survival in Lithuania.

Keywords: childhood cancer,survivors,late effects,toxicity,transition
AWARENESS, ALERT AND RESPONSE FOR CB THREATS IN FOOD DEFENCE (REACTION)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Disaster-Resilient Society for Europe
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Italy,Spain,United Kingdom,Colombia,Romania,Croatia
Call: Prevention, detection, response and mitigation of chemical, biological and radiological threats to agricultural production, feed and food processing, distribution and consumption (HORIZON-CL3-2024-DRS-01, 2024)
Start date: 2025-09-01
End date: 2029-08-31
Duration (months): 48.0
Total project cost (EUR): 3999991.0
EU funding (EUR): 3999991.0
Participants: 14
Project status: SIGNED

The food chain is a sector that is vulnerable particularly to being jeopardised both by accidental events of contamination and intentional threat attacks. Since these incidents in most cases have cross-border impacts, effective collaboration among a wide range of international stakeholders is required to prevent where possible, or otherwise cope with these challenges. Unfortunately, at the European level, efficient tools for the identification and analysis, response and communication, and appropriate mitigation of, in particular, foodborne chemical (C) and biological (B) threats are either limited, or completely absent. The vision of the REACTION project is to increase Europe’s resilience towards foodborne chemical and biological (CB) threats. While in the food safety and food security arena, a significant number of successful international projects and initiatives are already underway, we believe that the food defence sector urgently requires additional attention. Our overall goal is to strengthen Europe’s food defence capability to respond to intentional malicious attacks, through (a) the development of a data-driven monitoring tool for food defence, (b) the development a cost-efficient and streamlined CB threat identification pipeline, (c) the development of AI-supported food defence management tool, (d) the creation of a European-led International Food Defence Expert Forum, and (e) the design of an information awareness raising campaign for CB threats. REACTION is driven by an experienced consortium of 14 leading European Institutes, Universities (including SSH experts), national food safety and defence authorities, agri-food chain representatives, as well as technology providers, who will cooperate with an International Advisory Board of world-class actors from the food defence arena.