Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Role of PSIP1 in prostate cancer development and drug resistance (PSIPCancer)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-05
End date: 2023-01-18
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Understanding the cancer-specific genetic alterations is fundamental to devising novel treatment modalities. This project aims at understanding the role of PSIP1, posterior homeotic domain-containing transcription factors (HOX TFs) and androgen receptor (AR) in transcriptional regulation of prostate cancer cells. These transcriptional regulators are integral to the normal cell homeostasis and are dysregulated in various cancers. Through the preliminary data and analysis, this proposal recognises an interlink between these three factors and the ability of this trio in mediating a cancer-specific transcriptional alteration through activation of cancer-promoting transcriptional enhancers. Using a powerful combination of genome editing, functional genomics and bioinformatics, this proposal aims to discover altered transcriptional programme and its impact on cancer progression and treatment resistance. This project combines the expertise of the researcher in cancer biology with the competences of the host in epigenetics and functional genomics. This project will impart the talented researcher with comprehensive research training in chromatin biology and functional cancer genomics at an elite research Institute, in order to increase his prospects to become an independent research leader. The researcher will also profit from postdoctoral training opportunities in transferable skills available at the host's institution. Completion of the research and training objectives will significantly shape the development of the researcher into an independent leader, assign him a firm place in the European research network

Keywords: prostate cancer,psip1,hox tfs,resistance
Researchers, key drivers of growth in Europe (MadridERN 2018-2019)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-05-01
End date: 2019-12-31
Duration (months): 20.0
Total project cost (EUR): 227320.0
EU funding (EUR): 200000.0
Participants: 1
Project status: CLOSED

Under the motto Researchers, the key drivers of growth in Europe, the European Researchers’ Night in Madrid aims to highlight the important role researchers play in European citizens welfare not only as the engine of technological innovation but also by their contribution to the advancement of knowledge in Europe and beyond, finding answers to the main challenges facing modern societies. The MadridERN project as a communication and public engagement action is addressed to citizens of the Region of Madrid that aims to bring researchers and their work closer to the public at large and to promote research careers among young people without gender barriers from very early ages. To achieve this goal a wide and strong awareness campaign with a sound communication plan will be launched combining the traditional communication vectors (written press, radio, tv public advertising or street adverts) with the new ones (websites, social networks: YouTube Instagram, Facebook, LinkedIn and Twitter) with the purpose of making known the event and if possible to become “trending topic” for a while. The event aims to attract as much people as possible by transmitting the main messages of the Night, i.e: Science is for all of us; The diversity of Researchers, Researchers are amongst us; Researchers are ordinary people with an extraordinary job; Research is fun; Being researcher is exciting; Researchers improve your everyday life; Play researcher for a night; Discover what researchers do and can do for the welfare of Europe.

Keywords: european researchers night,researcher,society,public recognition,public engagement,research job,schools,citizens,entrepreuners,students
Pharmaceutical Open Innovation Test Bed for Enabling Nano-pharmaceutical Innovative Products (Phoenix)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Innovation actions
Countries involved: Germany,Spain,Austria,Austria,Spain,Germany,Croatia,Netherlands,Luxembourg
Call: Open Innovation Test Beds for nano-pharmaceuticals production (IA) (H2020-NMBP-TO-IND-2020-twostage, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 14452319.5
EU funding (EUR): 11102823.04
Participants: 12
Project status: SIGNED

Nano-pharmaceuticals have the potential to drive the scientific and technological uplift, offering great clinical and socio-economic benefits to the society in general, industry and key stakeholders and patients. Nevertheless, affordable and advanced testing, manufacturing facilities and services for novel nano-pharmaceuticals are main prerequisites for successful implementation of these advances to further enhance the growth and innovation capacity. The establishment of current good manufacturing practice (cGMP) in nano-pharmaceutical production at large scale is the key step to transfer successfully the nano-pharmaceuticals from bench to bedside (from lab to industrial scale). Due to the lack of resources to implement GMP manufacturing at-site, the upscaling and production of innovative nano-pharmaceuticals is still challenging to main players of EU nanomedicine market, start-ups and SMEs. To allow successful implementation of the nano-pharmaceuticals in the nanomedicine field, there is an urgent need to establish science- and regulatory-based Open Innovation Test Bed (OITB). Phoenix aims to enable the seamless, timely and cost-friendly transfer of nano-pharmaceuticals from lab bench to clinical trials by providing the necessary advanced, affordable and easily accessible Phoenix-OITB. Phoenix-OITB will offer a consolidated network of facilities, technologies, services and expertise for all the technology transfer aspects from characterization, testing, verification up to scale up, GMP compliant manufacturing and regulatory guidance. Phoenix-OITB will develop and establish new facilities and upgrade existing ones to make them available to SMEs, starts-up and research laboratories for scale-up, GMP production and testing of nano-pharmaceuticals. The services and expertise provided by the OITB will include production and characterization under GMP conditions, safety evaluation, regulatory compliance and commercialisation boost.
De novo Development of Polarity in Plant Cells (DENOVO-P)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Austria,United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2025-09-30
Duration (months): 84.0
Total project cost (EUR): 2499224.0
EU funding (EUR): 1980378.74
Participants: 2
Project status: SIGNED

The polarity of the single cell from which many organisms develop determines the polarity of the body axis. However, the polarity of these single cells is often inherited. For example, zygote polarity is inherited from the polarized egg cell of Arabidopsis thaliana. By contrast, polarity is not pre-set in the spore cell that forms the Marchantia polymorpha (Marchantia) plant. An environmental cue – directional light – polarises the spore cell which, in turn, directs the formation of the first (apical-basal) axis and the fates of the two daughter cells formed when the spore cell divides. Using Marchantia, we will discover how cell polarity is established de novo in the developing spore cell and how this, in turn, directs the specification of the first major axis in the plant. The proposed research is feasible because of the unique characteristics of the Marchantia system: 1. Isolated single apolar cells become polarized allowing us to exploit the real-time imaging with experimental manipulation of polarising cues at each stage of development. 2. Haploid genetics can be exploited to carry out genetic screens of unprecedented depth and we can identify mutant genes using a fully annotated genome sequence. 3. Gene expression can be measured with high temporal resolution during polarization. We propose to: 1. Describe the cellular and morphogenetic events that occur as the spore cell polarizes, divides asymmetrically to form cells at either end of the apical-basal axis. 2. Define the mechanism underpinning the de novo establishment of polarity using a combination of forward and reverse genetics and determine if this mechanism is conserved among land plants. 3. Determine the role of auxin in transmitting spore cell polarity to the cells at both ends of the apical-basal axis. This will describe, for the first time, the molecular mechanism controlling the de novo polarization of a single cell that develops into a plant.

Keywords: polarity,marchantia,evolution
Industry 4.0 for SMEs - Smart Manufacturing and Logistics for SMEs in an X-to-order and Mass Customization Environment (SME 4.0)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria,India,Italy,Slovakia,Thailand,Slovakia,United States
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 954000.0
EU funding (EUR): 783000.0
Participants: 8
Project status: CLOSED

Industry 4.0 refers to the fourth industrial revolution and technological evolution from embedded systems to cyber-physical systems (CPS) in production. The main objectives of Industry 4.0 can be summarized as the introduction of intelligent systems in production and logistics, the development of highly adaptable and modular manufacturing and logistics systems, the integration of sustainable and advanced manufacturing technologies as well as the promotion of automation technology and human-machine interaction. In the context of Industry 4.0 new ICT and web technologies act as booster or enabler of smart, autonomous and self-learning factories facing the challenges of even more individualized and customized product portfolio. A great challenge for the future lies in the transfer of Industry 4.0 expertise and technologies in small and medium sized enterprises (SME). SMEs represent the backbone of the economy and have an enormous importance in the development programs of the European Union for strengthening the competitiveness of European enterprises. Although the high potential of Industry 4.0 in SMEs, the main limit lies in a lack of concrete models for its implementation and application in small and medium enterprises. Thus, this research project titled “Industry 4.0 for SMEs - Smart Manufacturing and Logistics for SMEs in an X-to-order and Mass Customization Environment” aims to close and overcome this gap through the creation of an international and interdisciplinary research network. Identifying the needs and enablers for a smart and intelligent SME-Factory, creating adapted concepts and design solutions for production and logistics systems in SMEs and developing suitable organisation and business models will be the three main objectives of this research network. The applicability of the results is ensured through a close collaboration with a European small and medium sized enterprise (non-academic partner) from mass customization industry.

Keywords: industry 4 0,cyber physical systems,manufacturing systems,logistic systems,mass customization,small and medium sized enterprises,business models
Business Cycle Causes and Consequences (BUCCAC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1729806.25
EU funding (EUR): 1729806.0
Participants: 1
Project status: SIGNED

Business cycles impact on a large cross-section of the population simultaneously and matters for welfare. Gordon Brown stated in 2002: “There will be no return to boom and bust” but in 2007/08 the Global Financial Crisis triggered the Great Recession, the deepest recession since the 1930s. Mainstream macro (representative agents, complete markets, competitive/monopolistic behavior, full information) was criticized rightly or wrongly for failing to predict the crisis. But the field is now undergoing a significant change introducing financial frictions, partial information, heterogeneous agents, non-competitive behavior etc. to study macroeconomic fluctuations. This high-risk project will make fundamental contributions to this new agenda and will do so in an ambitious and unusual integrative fashion using both empirical and theoretical approaches. The proposal has three aims each of which has several sub-projects. The first focuses on methods for dynamic causal analysis. We develop methods for dynamic causal analysis in the face of permanent and transitory shocks using external instruments. The second provides new evidence on the sources of business cycles and their propagation. We examine the dynamic macroeconomic effects of “market power” by producing a new narrative record of regulatory changes. We will also study the macroeconomic impact of expectational shocks unrelated to “fundamental” shocks. The third aim builds quantitative theory. Dynamic general equilibrium models will be used understand the impact of market power focusing on intangible customer market effects. We apply heterogeneous agents models with aggregate shocks to examine financial frictions and macro prudential regulation in models with idiosyncratic risk. We study expectations-driven fluctuations in incomplete markets models. We estimate models with incomplete markets and price rigidities which provides a contribution across the three aims.

Keywords: dynamic causal analysis,heterogeneous agents,incomplete markets,imperfect competition,expectations,financial frictions
Capillary systems for advanced point-of-care diagnostics (CAPSYS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Switzerland
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-01-01
End date: 2021-12-31
Duration (months): 48.0
Total project cost (EUR): 515332.7
EU funding (EUR): 515332.7
Participants: 2
Project status: CLOSED

The worldwide in vitro diagnostic (IVD) is continually growing. At least 36% of the IVD market comprises point-of-care (POC) tests, which are performed by healthcare professional in various settings or by patients themselves. A large number of companies entered the POC testing market in the recent years while bringing significant technological improvements and novel concepts to this market. Yet, many important needs for immunodiagnostics are unmet: POC tests still require relatively large volumes of samples, cannot readily be multiplexed, are not always accurate, and often involve simple liquid displacement "from point A to point B" with minimal control over the distribution of reagents and kinetics of reactions. Here, we propose a synergistic project aiming at developing simple-to-use and high-performance microfluidic capillary systems ("CAPSYS") for POC testing. Each part of the project will correspond to a complete PhD work with specific skills, methodology, and know-how from the academic and industrial PIs. The common theme for both projects will be the use of capillary forces for the autonomous filling of microfluidics by samples and liquids and the integration of reagents and receptors for analyte detection inside the microfluidic chips. Those microfluidic chips will allow 1-step assays, i.e. assays wherein a non-technical user only needs to load a sample to the chip for performing a biological test. CAPSYS will lead to a new state of the art in terms of POC testing with significant relevance in medicine and diagnostics. CAPSYS will therefore be ideal for early stage researchers (ESRs) in terms of learning various disciplines in depth, creating numerous opportunities for publishing, and working on problem-oriented research that can have an impact in the "real world".

Keywords: capillary driven microfluidics,1 step immunoassays,immunodiagnostics,point of care,diagnostics
Supracellular contractility dynamics and cell communication during collective chemotaxis. (SUPRACELL_COMMUN_CCT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Collective chemotaxis (CCT) is a fundamental process for embryonic development and cancer metastasis, where groups of cells collectively migrate in response to a chemoattractive signal. While single cell migration depends on polarised actomyosin mechanotransduction and signalling cascades within the same cell, in CCT these functions are shared between different cells to achieve a coordinated, ‘‘supracellular’’ translocation. The molecular mechanisms underlying coordination and cell-cell communication during CCT have been largely overlooked. I propose to address this issue using the neural crest (NC), a highly invasive mesenchymal cell population that migrates throughout the embryo via CCT. NC migration shows extensive similarities with cancer invasion, making it a useful model for studying metastatic migration. Preliminary experiments show that an actomyosin ring-shaped cable, which surrounds the NC cluster, contributes to maintain a supracellular organisation. Also, during CCT, gap junctions appear to regulate synchronous actomyosin contractions in cells located at the cluster’s rear. Therefore, I will study this contractility dynamics in-vitro and in-vivo using Xenopus and zebrafish. I will manipulate the actomyosin cable to understand its contribution to efficient chemotaxis. Then, I will investigate how gap junctions enable synchronisation between neighbouring cells, by imaging the spread of calcium waves in NC clusters and manipulating other diffusible messengers. This study will give significant insights into the mechanisms regulating CCT, which is crucial for deepening our understanding of morphogenesis and cancer biology.

Keywords: collective chemotaxis,neural crest,gap junctions,actomyosin,calcium waves
Wide Incremental learning with Discrimination nEtworks (WIDE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-09-01
End date: 2022-08-31
Duration (months): 60.0
Total project cost (EUR): 2496875.0
EU funding (EUR): 2496875.0
Participants: 1
Project status: CLOSED

Although homo sapiens has been endowed with language for over 50,000 years, the invention of alphabet-like scripts 3,000 years ago dominates Western linguistic thinking. Training in literacy starts in early childhood, and because of this, words and letter-like sound units can naturally seem to be the building blocks of language. The Chinese writing system highlights the cultural-specificity of this approach: characters are juxtaposed without intervening spaces, and their interpretation is highly context-dependent. Words are not singled out. And although more frequent characters contain parts indicating pronunciation, it is syllables that are referred to, not letter-like sound units. The research proposed here seeks to break the hold that the alphabet-centric approach has on our understanding of language by exploring the idea that instead of being phone and word-based, languages use low-level properties of the acoustic signal to directly reduce uncertainty about the messages encoded in the speech signal. My work with wide learning networks (two-layer networks with many thousands of units, using the simplest possible error-driven learning rule) provides remarkable support for this suggestion: For reading and speech comprehension, their performance closely matches both the strengths and the weaknesses of human processing. Especially at a time when machine learning and artificial intelligence are moving beyond human capacity, it is a methodological imperative to study and work with algorithms reflecting both the advantages and disadvantages of human learning. I am requesting funding to take this radically novel research program to the next level by further developing our account of auditory comprehension, by modeling more typologically diverse languages, by extending this approach to speech production, and by developing a discrimination-based language theory.

Keywords: wide learning,speech comprehension,speech production,computational modeling,naive discrimination learning