Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Formation of Black Hole Mergers in Dense Stellar Systems (BlackHoleMergers)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-12-01
End date: 2021-11-30
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: CLOSED

The recent pioneering observations of gravitational waves (GWs) from merging black holes (BHs) by LIGO/Virgo have already led to new remarkable insight: From the first few events we have learned that BHs do indeed exist, that Einstein's General Relativity (GR) seems to very well describe their merger and ring-down evolution, and that nature is able to pair BHs in compact binary systems. However, many astrophysical key questions still remain unsolved, including, how and where BHs form and what helps them to get close enough to merge on an observable timescale. The project I propose will provide new state-of-the-art insight into such fundamental questions by addressing how BBHs form and merge in dense stellar systems, as well as how well one can infer their origin from their emitted GW signal. In order to achieve this goal, I will develop a new numerical Monte-Carlo framework for evolving dense stellar systems, which for the first time will include: stellar tidal interactions and GR corrections during strong few-body scatterings, orbital diffusion from weak encounters, and secular effects near a possible central massive BH. From my recent analytical models, these effects are expected to lead to the formation of eccentric BBH mergers, as well as other exotic populations, all of which can be used to constrain the dynamical origins of BBHs. The goal is to provide the community with accurate BBH merger distributions that can be used to constrain the origin of BBH mergers using incoming data from LIGO/Virgo. I will carry out the project at the Niels Bohr Institute under the supervisions of Prof. Martin Pessah and Niels Bohr Prof. Enrico Ramirez-Ruiz. The interdisciplinary environment, vibrant atmosphere, and exceptional scientists make the Niels Bohr Institute not only the ideal host for this project, but further ensures that I will mature into a true intellectual leader in my field during the time of the Marie Curie Fellowship.

Keywords: relativistic dynamics,evolution of dense stellar systems,black hole mergers,n body simulations,origin of gravitational wave sources
Prospering without growth: Science, Technology and Innovation in a post-growth era (PROSPERA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1424375.0
EU funding (EUR): 1424375.0
Participants: 1
Project status: SIGNED

The feasibility and desirability of endless economic growth is increasingly being questioned by scholars and activists. While envisioning alternative economic models is key to assure the sustainability and wellbeing of present and future generations, few studies have analysed what might be the role of ‘innovation’ in a post-growth era. Innovating has become the imperative for the survival and expansion of any form of organisation. But this ‘innovate or die mania’ underpins assumptions – such as technological determinism and productivism - that neglect the socially constructed character of technological development, its politics and its capacity to enable just and equitable societies but also dystopian technocratic futures. This project posits that untangling innovation from growth is key to imagining a post-growth era. If growth is going to be unsustainable, we need new narratives for innovation that would accordingly also have to change and increase the scope of the innovation concept itself, beyond technology, into cultural and institutional change, and indeed social life and social order. Organizations – in particular capitalist enterprises - are the core of modern industrial societies but are also one of the places in which the discourse of growth is legitimised and constantly reproduced. However, they can also be the places in which people can start to build the capacity for developing alternatives to challenges the growth ideology. But how organizations would look like in a different paradigm, in a system that is not based on and doesn’t not rely on endless growth? Under which conditions STI without growth would be able to flourish? What levels of technological complexity can we reach in a non-growing economy? What policies, infrastructures and organizational forms are needed or are more likely to facilitate this new paradigm of STI? These are questions, rarely asked by innovation, management and organization scholars, that the proposed project will address.

Keywords: post growth,degrowth,post capitalism,managing without growth
How to Build an Eye - Dissecting the coordination between cellular rearrangements and the interplay with material properties of the tissue during Optic Cup Morphogenesis (HowToBE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-03-2020, 2020)
Start date: 2022-03-01
End date: 2024-02-29
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: SIGNED

Organogenesis arises from the collective arrangement of cells into a progressively 3D shaped tissue. The acquisition of a correct shaped organ is a result of a complex interplay between molecular cues, responsible for differentiation and patterning, and the mechanical properties of the system, which generate the necessary forces that drive correct shape emergence. Therefore, it is important to understand how the cross talk between these two players leads to changes in cell behaviours and how these changes are translated into epithelial sheet movement and, consequently, to morphogenesis. This project aims to contribute to a global understanding of shape formation during organogenesis, by using the vertebrate retina as a model system. I will use the zebrafish optic cup, with its unmatched possibilities for in vivo 3D imaging and manipulation, to dissect the biomechanical events at single cell level, that collectively lead to shape emergence. I will then test if the identified crosstalk of morphogenetic events is kept in other time scales of optic cup formation, by studying a slower developing organism. Alongside with experimental approaches, a physical model of the mechanics and shape dynamics of OCF, based on the experimental data of morphological changes, will be generated and experimentally tested. The multidisciplinary approach of this project and the revealed mechanisms of OCF in 3D will have the potential to be applied in other morphogenetic studies of 3D curved tissues.

Keywords: morphogenesis,eye development,quantitative biology,organogenesis,imaging,biomechanics,evolution of morphogenesis
Physiological consequences of Protocadherin-10 sumoylation on neuronal function. (SUMO-PCDH10)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

Sumoylation is an essential post-translational modification that regulates a wide range of cellular functions. Interestingly, several proteins involved in synaptic functions have been shown to be SUMO targets. Unpublished data from my current lab identified a list of SUMO substrates at the synapse. Among them, we find Protocadherin-10 (PCDH10), an autism-related cell adhesion transmembrane protein. Mice lacking one copy of Pcdh10 gene present abnormal spine density and morphology, reduced expression of NMDA receptors in the amygdala and sociability deficits. Furthermore, PCDH10 recruits ubiquitinated PSD-95 to the proteasome and promotes synapse elimination. These findings demonstrate that PCDH10 is centrally involved in the regulation of synapse density and function. However, whether the sumoylation of PCDH10 plays a role in this process remains to be elucidated. Thus, I performed a bioinformatic analysis showing that the lysine 831 (K831) of PCDH10 has a high SUMO predictive value. Interestingly, the K831 is located in the proteosomal interacting region (PIR), which is critical to allow PSD-95 degradation and, consequently, synapse elimination. Sumoylation regulates protein-protein interactions by providing novel docking sites or promoting the dissociation of the binding. Therefore, I hypothesize that sumoylation of PCDH10 is crucial for synapse elimination by regulating the interaction with the proteasome. Thus, the overall goal of my research project is to unveil the physiopathological consequences of PCDH10 sumoylation in neurons. Since synapse elimination is impaired in several neurodevelopmental disorders, I am confident that the data arising from this work will provide groundbreaking knowledge in the understanding of the molecular mechanisms underlying ID in patients carrying Pcdh10 mutations. Furthermore, uncovering the impact of sumoylation on the development of mental disorders will open up a thrilling topic in the neuroscience field.

Keywords: sumoylation,pcdh10,synapse elimination,autism spectrum disorders,hippocampal neurons
Islamic - Chinese Cultural Exchange: Chinese Influence on Islamic Art, 13th - 16th Centuries CE (ICCE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

This research project aims to address the intercultural interactions between the Islamic Middle East and China from the 13th to 16th centuries CE. The period from the 13th to 16th centuries CE witnessed a second wave of Chinese influence on Islamic material culture. The continuous active engagement of Muslims in the exploration of and exchange with foreign lands, such as with China through Mongol khanates in Eurasia, enabled some Chinese artworks and artistic elements to be known and appreciated by courts, noble patrons and general people in the Islamic Middle East. Islamic artists started to incorporate these Chinese artistic elements into their artworks, though sometimes in markedly revised form. New techniques and decorative motifs were invented based on inspirations from these Chinese elements to suit the aesthetic interests and tastes of local Islamic patrons and to fit the principles of Islam. This project aims to tackle the following questions: through whom and under what historical and social context were Chinese artworks exchanged to the Islamic Middle East? Who were the patrons for these Chinese artworks and Islamic artworks with Chinese artistic elements? Where were they consumed, in a court or another context? Was there a gender difference in the exchange, patronage and consumption? How were these Chinese elements incorporated and adapted in local Islamic art? How were these Chinese elements perceived at that time in the Islamic Middle East; were their original symbolic meanings retained in the local context? This project will devise interdisciplinary research of material cultures with a synthesis of methodologies and approaches of art history and archaeology. It will set up two datasets of Chinese artworks found in the Islamic Middle East and Islamic artworks with Chinese influence, 13th - 16th centuries CE, with a priority of those found from archaeological excavations and those with a detailed context.

Keywords: islamic,china,middle east,cultural exchange,intercultural interaction,silk road,eurasia
Innovative Software Configurator for the Insurance sector (i2S-IC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Portugal
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-11-01
End date: 2017-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Insurance companies are locked into old complex technology. The insurance market has been disrupted by new technologies, devices and infra-structures that create new products, like usage based insurance, new distribution models like Internet aggregators and new interactions with customers through mobile devices. The insurance industry needs to rid itself of the legacy platform problem, but this is neither easy nor fast, and increasingly alternative solutions that leap frog the problem are gaining traction such as modernizing the peripheral applications around existing systems. While this approach provides a fast solution to pressing commercial problems it does not address the residual risk: that one day the core system, a burning platform, must be replaced. The i2S solution presents a disruptive approach to this problem that is to address change in two stages: first extracting from the existing system the key core knowledge about insurance products, commercial structures, process configuration while core systems and experts that know them are available; and second, having made this knowledge independent of core system, it can now be applied to any new solution or used to keep the existing solution working with a lower risk, even when the original builders are no longer around. This solution is the i2S Insurance Configurator (i2S-IC), an innovative one stop shop for configuration, allowing safe, quick, centralized, consistent and guided configuration, strategically enabling the capture and reuse of the business knowledge that is at the core of any insurance company.

Keywords: insurace software,configurator,workbench,disruptive
Green chemicals and technologies for the wood-to-textile value chain (GRETE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Austria,Spain,Italy,Finland,France,Portugal,Portugal
Call: Apply emerging breakthrough technologies to improve existing value chains (H2020-BBI-JTI-2018, 2018)
Start date: 2019-05-01
End date: 2023-04-30
Duration (months): 48.0
Total project cost (EUR): 2788443.75
EU funding (EUR): 2555243.7499999995
Participants: 10
Project status: CLOSED

The GRETE project will tackle the challenges caused by increased global demand for sustainable textile fibres by offering new breakthroughs in the wood-to-textile value chain. The substitution of cotton by man-made cellulose fibres is also necessary because of sustainability issues. Currently the raw material base for the production of man-made cellulose fibres from wood is limited, as only highly processed dissolving grade pulps are used industrially. GRETE will introduce technologies by which paper grade pulps from softwood and hardwood sources can be used as raw material for man-made textile fibres. GRETE will also offer safe and sustainable solvent systems for the production of regenerated cellulose fibres, instead of the present ones which are based on toxic or explosive chemicals. The developed novel solvents are ionic liquids (IL’s), which will be non-toxic, recyclable and synthesized from low-cost industrially available chemicals. GRETE will also develop innovative technologies for chemical modification and enzymatic pre-treatment of pulps prior to cellulose dissolution. Chemical modification carried out either before or after dissolution and regeneration of pulps will bring chemical functionalities to fibres. The modifications either directly improve fiber properties (e.g. decreased fibrillation, improved fire resistance) or offer an easy route to further fibre processing. Improved dye adsorption and chemical reactivity will offer new options for dyeing and finishing treatments of the fibres, enabling e.g. the creation of a water-scarce end to the textile manufacturing value chain as well as open up the possibility for other targeted and water-scarce finishing treatments.
Lipid asymmetry: a cellular battery? (ASYMMEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

It is a basic textbook notion that the plasma membranes of virtually all organisms display an asymmetric lipid distribution between inner and outer leaflets far removed from thermodynamic equilibrium. As a fundamental biological principle, lipid asymmetry has been linked to numerous cellular processes. However, a clear mechanistic justification for the continued existence of lipid asymmetry throughout evolution has yet to be established. We propose here that lipid asymmetry serves as a store of potential energy that is used to fuel energy-intense membrane remodelling and signalling events for instance during membrane fusion and fission. This implies that rapid, local changes of trans-membrane lipid distribution rather than a continuously maintained out-of-equilibrium situation are crucial for cellular function. Consequently, new methods for quantifying the kinetics of lipid trans-bilayer movement are required, as traditional approaches are mostly suited for analysing quasi-steady-state conditions. Addressing this need, we will develop and employ novel photochemical lipid probes and lipid biosensors to quantify localized trans-bilayer lipid movement. We will use these tools for identifying yet unknown protein components of the lipid asymmetry regulating machinery and analyse their function with regard to membrane dynamics and signalling in cell motility. Focussing on cell motility enables targeted chemical and genetic perturbations while monitoring lipid dynamics on timescales and in membrane structures that are well suited for light microscopy. Ultimately, we aim to reconstitute lipid asymmetry as a driving force for membrane remodelling in vitro. We expect that our work will break new ground in explaining one of the least understood features of the plasma membrane and pave the way for a new, dynamic membrane model. Since the plasma membrane serves as the major signalling hub, this will have impact in almost every area of the life sciences.

Keywords: lipid asymmetry,lipid dynamics,photochemical probes,chemical biology
The impact of supplementary feeding on the food searching strategies and social behaviour in an endangered top scavenger (SocForVul)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

The provision of surplus food at supplementary feeding stations is a worldwide practice to facilitate the recovery of endangered species like vultures, which have experienced dramatic population declines during the past century. Despite considerable research on the effects of supplementary feeding on the viability of populations, there is almost a total lack of knowledge on the effects of these practices at the individual level. In the proposed project (Social Foraging in Vultures, “SocForVul”), I will use the newest advances in bio-logging techniques to investigate the impact of supplementary feeding on food searching behaviour (via GPS/acceleration data-logging) and the social dynamics (via proximity data-logging) of the endangered Canary Egyptian Vulture. This research project aims to combine concepts from the fields of Animal Personality and Social Network Theory, using cutting-edge analytical techniques, to quantify the relative ability of individuals to cope with human-induced environmental changes. The Fellowship will provide me with a unique opportunity to deepen my knowledge on consistent individual differences in behaviour and expertise in the use of modern technology for field research, improve my analytical skills, and develop new expertise in behaviour-based wildlife management. Performing my research at The Doñana Biological Station, which is one of the best research locations in Europe for fundamental research and conservation, will guarantee high quality training and excellent research output. The proposed research holds excellent prospects for interdisciplinary collaborations and career opportunities. Finally, from a conservation point of view, information on the impact of supplementary feeding on the social life of vultures will undoubtedly improve current guidelines for this conservation strategy and help sustaining healthy populations of scavengers as well as maintaining important ecological and evolutionary processes.

Keywords: supplementary feeding,individual variation,foraging strategies,social dynamics,social network theory,conservation biology,proximity logging,acceleration data,egyptian vulture