Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Origami-DNA/AgNCs Sensor for Detection of miRNAs (ODASMIR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Breast cancer (BC) is a prevalent kind of cancer worldwide and it is one of the primary causes of cancer-related deaths in women. The research has shown that early detection of BC could significantly increase the chances of survival for patients. Recently, there has been a growing interest in microRNAs (miRNAs) as potential biomarkers for the early diagnosis of BC. Therefore, the development of new diagnostic tools for the early detection of BC is necessary. Thus, biosensors based on DNA nanotechnology emerge as a novel, versatile, and easily accessible alternative. In this context, the synergy between the fluorescence properties of DNA/AgNCs and the structural properties of DNA-origami will allow the creation of a new generation of hybrid nanomaterials (nanohybrids), which could be conceived as biosensors for the detection of miRNAs associated to BC with high sensitivity, sequence specificity, high throughput, low cost, and easy access. ODASMIR aims to design origami-DNA/AgNCs nanohybrids (ODAs) to develop a biosensor to diagnose BC through the detection of different miRNAs and, it will validate in in vitro models (2D and 3D). ODASMIR presents a multidisciplinary approach, both the objectives and the experimental methodology are on the interface between biology and chemistry. The biosensors obtained and their validation at the clinical level could have a significant impact on the accurate and early diagnosis of BC representing a significant advance in the field of nanomedicine.

Keywords: dna nanotechnology biosensor mirnas breast cancer fluorescence
Tracking the dispersal of humans from the African Rift to the Pacific Rim using biomolecular approaches (RIFT-to-RIM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-07-01
End date: 2030-06-30
Duration (months): 60.0
Total project cost (EUR): 2710949.0
EU funding (EUR): 2710949.0
Participants: 1
Project status: SIGNED

Modern humans (Homo sapiens) evolved in Africa, dispersed into Eurasia, and reached the vast landmass of Sahul (present-day Australia, Papua New Guinea, and Tasmania) by ~60,000 years ago. During this remarkable expansion, interbreeding between H. sapiens and other hominin taxa shaped and redefined our species’ genetic profile. Yet, the scarcity of fossils and ancient molecular data from Africa and Sahul, the starting and ending points of this journey, leave unanswered questions regarding the origins, age, and genetic imprints of the groups venturing from the African homeland, and of those reaching Sahul. RIFT-to-RIM is an ambitious project that builds on the foundation of the PI’s previous ERC work (FINDER) in Asia, and aims to rectify the dearth of fossils and genetic evidence from two under-researched regions of the world, sub-Saharan Africa and Sahul. Through a novel and systematic combination of cutting-edge biomolecular methodologies, a carefully designed workflow targets 21 African and Papuan sites dating to between 200,000-10,000 years ago. To minimise the impact of collagen and DNA degradation the project relies heavily on high-elevation sites, coupled with analytical developments for poorly preserved samples. Thousands morphologically non-diagnostic bones (~180,000) will be assessed non-destructively using Near-infrared spectroscopy, and a fraction of them (~20,000) will be determined taxonomically using palaeoproteomics, primarily ZooMS. Newly identified hominin bones will undergo ancient DNA, dating and isotopic analyses. Sediments from new and previously-excavated sites will be screened for modern human DNA evidence. The RIFT-to-RIM workflow maximizes our chances of identifying, dating, and genetically characterizing early H. sapiens in regions where such data are exceptionally rare. Ultimately the project will generate a wealth of new evidence from key regions of the world and will help decod the intricate mosaic that defines modern humans today.

Keywords: palaeolithic biomolecular archaeology human evolution palaeoproteomics
Micronutrients in sustainable and nutritious diet (MICROSUNSET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark,Germany,Finland,Ireland,Netherlands,United Kingdom,Australia,Belgium,Norway
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 3897003.6
EU funding (EUR): 3897003.6
Participants: 21
Project status: SIGNED

The goal of the MSCA-Doctoral Network "Micronutrients in sustainable and nutritious diet" is to train young scientists in micronutrients (vitamin and mineral) research to ensure that future sustainable diets provide these essential nutrients to promote healthy lives for populations globally. Hidden hunger is a challenge in Europe, which may worsen in the transition toward a more plant-based diet. Micronutrients from plant-based food compared to food of animal origin are considered less bioavailable, and some micronutrients are either absent or in insignificant amounts in plants. In MICROSUNSET the objectives are to 1) establish models to assess the bioavailability of micronutrients in foods and supplements, 2) investigate strategies to increase the content and/or bioavailability of micronutrients in plant-based products beyond fortification, 3) develop advanced methods for quantification of micronutrients, 4) conduct survey to investigate consumers acceptance of plant-based food products, 5) empower consumers, health professionals, scientists, and food product developers to choose and advise foods, meals and diets with superior nutrient delivery. The data obtained in this project will provide new fundamental understanding of the effect of production processes of foods, supplements and fortified foods on bioavailability of the individual micronutrients from plant-based foods versus food of animal origin. This will be essential for future recommendations for dietary intake and the evaluation of new food ingredients and products. The young researchers will participate in a wide doctoral training program covering all aspects of micronutrients from food production towards improved sustainability. Through the MICROSUNSET network we expect young researchers to become highly employable scientists with practical and qualified knowledge within the food and nutrition sciences for a career in academic, industries and public authorities.

Keywords: minerals,vitamins,plant based food,sustainable diet,bioaccessibility,bioavailability,enrichment,consumers
RESTORATION OF THE DANUBE RIVER BASIN WATERS FOR ECOSYSTEMS AND PEOPLE FROM MOUNTAINS TO COAST (DANUBE4all)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Austria,Netherlands,Romania,Germany,Serbia,Slovakia,Italy,Croatia,Ireland,Bulgaria,Slovenia,Hungary,United Kingdom,Ukraine
Call: Danube river basin lighthouse – restoration of fresh and transitional water ecosystems (HORIZON-MISS-2021-OCEAN-02, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 8422267.5
EU funding (EUR): 7968216.13
Participants: 49
Project status: SIGNED

Over one million barriers on Europe’s rivers have resulted in extensive loss of river connectivity and 70-90 % of Europe’s floodplain areas are ecologically degraded due to human modifications. Despite having an ambitious EU policy framework in place, implementation of fresh and transitional water ecosystem restoration is lagging behind. Reasons for this lie among others in a lack of knowledge, awareness and participation of local people and business actors. The overall aim of DANUBE4all is the development of a comprehensive Restoration Action Plan for the Danube river basin lighthouse developed in an unprecedented co-creation process with stakeholders, integrating citizens’ interests to support the Mission “Restore our ocean and waters by 2030”. Based on solid scientific knowledge and new findings, the Action Plan will promote the improvement of ecological status, biodiversity and ecosystem connectivity. The development and implementation of innovative “Win-Win Nature Based Solutions” will simultaneously lead to an enhanced free-flowing status of rivers and floodplains, flood and drought risk reduction and enhancement of sediment and biota continuity. The aim is to adapt to climate change as well as to improve the endangered biodiversity of ecosystems. This will be reached by identifying, processing and upscaling effective and economically profitable restoration measures. DANUBE4all will implement innovative demonstration activities at three sites in the Upper, Middle Danube and the Danube Delta. DANUBE4all will link ecological and economic benefits providing tailored business cases for SMEs, and will deliver innovative tools to accelerate citizens’ and stakeholders’ engagement. DANUBE4all will provide GIS and Citizen Science tools for upscaling these restoration actions via ten Synergy Sites to the Danube Basin and will also transfer the outcomes to five Associated Regions by concrete steps towards the development of Replication Roadmaps for restoration action.

Keywords: citizen science,river basin management,flood risk and drought risk management,climate change
Strategies to prevent and reduce plastic packaging pollution from the food system (STOPP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Finland,Slovenia,Germany,Spain,Belgium,France,Switzerland
Call: Strategies to prevent and reduce plastic packaging pollution from the food system (HORIZON-CL6-2023-ZEROPOLLUTION-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 3998452.0
EU funding (EUR): 3998452.0
Participants: 14
Project status: SIGNED

STOPP aims to STOP the ways that lead to environmental pollution, use of unsustainable virgin fossils, excess use of resources, high levels of generated plastic waste, incineration and landfilling, and climate change. We aim to do this by producing strategies for circular food plastic packaging with Refuse, Reduce, Redesign, Reuse and Recycle approaches. Our goal is to enhance sustainable and circular use of plastic food packaging and decrease the amount of generated waste while reducing the environmental impact. This is achieved via development and implementation of circular strategies together with an extensive network of plastics packaging value chain stakeholders, and citizens and consumers. Increased knowledge on the environmental and climate impacts of food packaging systems is a key driver in changing perception of reuse and recycling. We will quantify the effect of littered plastic food packaging on the environment with analysis of different ecosystems, biological organizational levels and key sentinel organisms. This deeper understanding is an important part together with different state-of-the-art and comprehensive enablers and barriers analysis for the technological developments, business strategies and consumer studies done in the project. Our technological approaches for reuse focus on safe and high-performance material development, improving return logistics, and developing consumer-centric communication strategies. For recycling, we will optimize collection systems, create safe food contact polyolefin recyclates, recycle bio-based and smart food packaging, and expand Plastics Recyclers Europe’ RecyClass certification scheme for recyclability. STOPP has a key role in supporting the Packaging and Packaging Waste Regulation implementation in its early stages via the developed novel solutions, providing new open access knowledge and hands-on tools for the value chain actors to start-up their sustainable circular food packaging journey as early adaptors.

Keywords: reusable packaging,mechanical recycling of plastics,post consumer plastic waste management,circular strategies,circular consumer research
CULTURAL AND CREATIVES INDUSTRIES AS INNOVATIVE DRIVERS TO IMPROVE URBAN QUALITY OF LIFE (CULT-IN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Other Culture, creativity and inclusive society destinations
Action type: Coordination and support actions
Countries involved: Spain
Call: Presidency event (ES) – Conference ‘Cultural and creative industries, cities and citizens and their role in the New European Bauhaus’ (HORIZON-CL2-2023-CCI-PRES-IBA, 2023)
Start date: 2023-04-01
End date: 2023-12-31
Duration (months): 9.0
Total project cost (EUR): 409813.94
EU funding (EUR): 300000.0
Participants: 1
Project status: CLOSED

The Spanish Presidency of the Council of the European Union will held during the second semester of 2023 a European Conference entitled ‘Cultural and creative industries, cities and citizens fostering sustainable development and the European way of living’. The objective is to reflect how the Cultural and Creatives Industries (CCIs) collaborate and contribute to improve people's quality of life by creating solutions through Culture and Science, The event will pretend to be an international meeting point between Culture and Science by displaying, in a demonstrative, interactive and participatory way, CCIs’ European and collaborative projects and initiatives that are not only innovative and sustainable, but also accessible, affordable, socially committed and enriching for all in line with the New European Bauhaus (NEB) initiative. In this way, the event will be able to reflect how cultural and creative industries can collaborate as social and innovative drivers through a collaborative network. The Conference will be organized held on 11, 12 and 13 July 2023 in Barcelona by the Spanish Foundation for Science and Technology (FECYT), in partnership with the Spanish Ministry of Science and Innovation and the Spanish Ministry of Culture and Sports.

Keywords: spanish presidency,culture,science,conference,cultural and creatives industries
Out-of-equilibrium dynamics of spatially confined Hamiltonian systems. (EDYSC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 2
Project status: CLOSED

The EDYSC project aims to establish the foundations of a theory of out-of-equilibrium dynamics of spatially confined waves. To this end, the project will use the Wave Turbulence theory as a reference point, which is well-established for the description of out-of-equilibrium dynamics of weakly interacting (unconfined) waves. The research program will study how spatial confinement affects some of the most characteristic processes of Wave Turbulence such as propagation of chaos, thermalization, or energy transfer. It will be done by considering the influence of the discrete nature of resonances between waves (characteristic of spatially confined systems) on these processes. This study will characterize the principles that a theory of out-of-equilibrium spatially confined waves must follow. This proposal lies in the interphase between various areas of nonlinear physics and mathematics, having an interdisciplinary interest, both theoretically and experimentally. The effects of discrete resonances on the dynamics of confined systems have been observed in disparate topics, such as nonlinear optics, Bose-Einstein condensates, gravity waves, general relativity, etc. These effects range from preventions of thermalization in light propagation in optical fibers to even the formation of arbitrarily small black holes. This wide range of applicability will be used to build synergies between the theoretical results of the project and experiments conducted by other groups. The methodology uses a hybrid approach, based on numerical methods to get insight into the heart of the problems followed by its analytic description. To this end, the project will study a family of spatially confined systems with excellent analytic properties, the so-called highly resonant Hamiltonian systems. These systems have an outstanding structure of resonances which is huge, trivial to calculate, and the most organized. They are very convenient to study effects associated with discrete resonances.

Keywords: hamiltonian systems,resonances,nonlinear waves,spatial confinement,out of equilibrium dynamics,non equilibrium dynamics,wave turbulence,mathematical physics
GROWING CONNECTION FOR BIO ECOSYSTEMS (COBIOE)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: France,Belgium,Portugal,Estonia
Call: Towards more inclusive networks and initiatives in European innovation ecosystems (HORIZON-EIE-2022-CONNECT-01, 2022)
Start date: 2023-03-01
End date: 2025-06-30
Duration (months): 28.0
Total project cost (EUR): 551019.29
EU funding (EUR): 499730.0
Participants: 6
Project status: SIGNED

COBIOE is project to interconnect innovation ecosystems to foster 4.0 industrial transition in the biopharmaceutical deeptech sector, sharing competences, information and opportunities, with the aim of ultimately converging toward a common and inclusive European strategy for bioproduction support. Specifically, the proposition will focus on the bioproduction sector that includes development of small molecules, biologics, drugs, innovative therapeutics (such as gene and cellular therapies), high technology drugs based on cell and molecular biology, and covers various applications in health (oncology, immunology, virology, rare diseases, etc…). COBIOE will reach the following objectives: - Provide a state of the art and exploitable overview of the European bioproduction value chain, focusing on European, national, regional strategy or existing initiatives, activities - Opening up the bioproduction field, by reaching out to isolated actors and territories bringing added value to the chain. - Building up bridges between sparse innovative ecosystems and initiatives opening up opportunities for isolated players. - Promote bioproduction ecosystems, the field and its potentialities in terms of green, digital and social transition, among various stakeholders and policymakers COBIOE proposal includes 5 health clusters/networks, preeminent and pioneers in the field of pharmaceutical biomanufacturing. Each partner complements each other in terms of competence and the partnership covers almost all European regions from north to south and east to west, including modest, moderate, strong and leading innovators. Moreover, each partner benefits from an extended network of stakeholders, from different technological sectors (materials science, artificial intelligence, biotechnology, blockchain, robotics, photonics, electronics and quantum information) and actors (universities, research, hospitals, funders…).

Keywords: bioproduction,bioprocessing,biotherapies
Promoting sustainable agriculture for pollinators (AGRI4POL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: France,Germany,United Kingdom,Netherlands,Sweden,Spain,Bulgaria,Czechia,Belgium,Slovenia,Romania,Italy,Switzerland
Call: Promoting pollinator friendly farming systems (HORIZON-CL6-2024-BIODIV-01, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 6000000.0
EU funding (EUR): 6000000.0
Participants: 23
Project status: SIGNED

Threats to pollinators and pollination services that support agriculture and provide benefits to people are a worldwide problem. AGRI4POL’s ambition is to assist the transition of agriculture from being a pressure on pollinators to becoming a positive force for managing and restoring pollinator biodiversity, crop pollination services, and co-benefits to ecosystems and people. To achieve this transition towards more pollinator friendly farming systems and value chains, AGRI4POL will advance scientific understanding of crop-farming system-pollinator relationships from the crop gene to the agroecosystem. By evaluating the genetic basis of crop floral traits attracting and rewarding crop pollinators, we will identify candidate crop lines suitable for breeding future pollinator-smart varieties. We will study how pollinator-crop relationships are modified in space and time, by the diversity and rotation of crop species and varieties, by ecological infrastructure (EI) comprising landscape features and non-crop habitats, and by future climate or land-use change. Synthesising this information from the gene to agroecosystem scale will allow us to provide integrated recommendations for optimising landscapes for crop pollination, pollinator biodiversity and multiple ecosystem benefits. AGRI4POL research will be framed and supported by early and sustained multi-actor engagement along agri-food chains to assure its relevance and the acceptability of management options to farmers and society. This multi-actor approach will also enable assessments of the socio-economic and policy obstacles and opportunities affecting the feasibility and uptake of pollinator-friendly farming at [sub]national, European and international scales. AGRI4POL will therefore showcase to farmers, agri-food actors, policymakers and society the importance of pollinator-friendly farming to food security and sustainability goals (EC Green Deal, Nature Restoration Law; UN SDGs).

Keywords: climate change,landscape,ecosystem services,socio economic,policy,plant genetics,plant physiology,pollinator networks,multiactor,transdisciplinary