Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Smartester: A browser-based, No-Code, All-in-one Software Testing Solution for Efficient, and Economical Automation. (Smartester)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 18.0
Total project cost (EUR): 5000000.0
EU funding (EUR): 5000000.0
Participants: 1
Project status: SIGNED

Smartester: A No-Code, Unified Software Testing Solution. Smartester is an innovative, no-code software testing platform designed to revolutionize how businesses approach automated testing. With a focus on accessibility, scalability, and cost-efficiency, Smartester enables users of all technical backgrounds to conduct complex software tests without requiring any coding knowledge. It supports a broad range of testing needs, including functional, performance, load, and API testing, all within a unified, user-friendly interface. The platform features distributed parallel test execution, AI-powered insights, and graph-based visualization for real-time analysis, allowing users to optimize testing and quickly identify issues. Additionally, Smartester offers cross-platform and cross-browser automation, making it versatile across different environments without needing custom scripts. With dynamic dashboards and detailed reporting, businesses can gain full visibility into their software’s performance. Designed to be both SaaS and on-premise, Smartester is adaptable for enterprises of all sizes, providing tailored solutions through enterprise licensing. The platform also incorporates project management tools and Scrum/Agile integrations to ensure seamless workflows for development teams. By making software testing economical, efficient, and accessible, Smartester is poised to be a game-changer in the software industry, helping companies reduce their reliance on fragmented testing solutions and outdated tools, ultimately improving time-to-market and product quality.

Keywords: browser based test automation,comprehensive,user friendly,cross platform,scalable,ai powered,distributed computing,innovative,agile ready,market ready,enterprise grade
Plasmonic magnifiers of single molecule dynamics (PLASMAG)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Czechia
Call: ERA Fellowships (HORIZON-WIDERA-2023-TALENTS-02, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: CLOSED

This project will develop a new method for spatial manipulation of light by designing and validating assemblies of plasmonic nanostructures and fluorophores to advance visualization of densely packed biological structures and their dynamics. The visualization of densely packed biological structures is extremely challenging, yet crucial for understanding dynamic biological processes in virtually any context; light manipulation at the nanoscale using plasmonic nanoparticles has the potential to magnify nanoscopic sample structure while simultaneously enhancing the optical response beyond the capabilities of current super-resolution microscopy techniques. While the ability of metal nanostructures to enhance the response of fluorophores has been utilized for decades, we are still far from understanding the underlying mechanisms of plasmonic enhancement. To fully exploit the potential of this approach, we need to know how spectral overlap between the plasmonic nanoparticle and the absorption and emission channels of the fluorophore affects the coupling efficiency and spatial projection. To translate these effect into applications, we have to understand how the fluorophore-particle distance affects the far-field projection of the fluorophore. We will use self-assembled DNA, single-molecule localization microscopy, and finite difference time domain electromagnetic simulations to measure, describe and reconstruct sub-diffraction limited shifts in the projection of plasmon-coupled fluorophores. This will let us pave the way to the design of a magnifying device aimed at visualizing densely packed biological structures. Fundamental understanding of plasmonic coupling obtained in this project will be directly applicable in various fields of research by providing a tool for high-resolution visualization of molecular structures and their dynamics in the form of plasmonic assemblies, and enabling precise control over enhancement in fluorescence and Raman systems.

Keywords: plasmonic enhancement,dna origami,metal nanoparticles,single molecule localization microscopy,spatial light manipulation
Personalised Adaptive Medicine (PERAMEDIC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Hungary,United Kingdom,Belgium
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-02-01
End date: 2027-01-31
Duration (months): 36.0
Total project cost (EUR): 1726876.9
EU funding (EUR): 1726876.9
Participants: 5
Project status: SIGNED

Personalised drug formulation is a hot topic but state of the art approaches are limited by low scalability, cost, and regulatory hurdles, while current polypill formulation efforts are hindered by liquid form or hot melt addition approaches, posing stability issues. These bottlenecks carry a great societal price, as the synergic boost of drug combinations was recently demonstrated to reach significant improvement in treatment outcomes, while keeping active substances in the ideal physiological concentration window is known to maximise efficiency and reduce side effects. Also, polypharmacy is a real problem leading to dosing errors and significant loss in patient adherence. Finally, while Big Data Health IT system concepts on the far horizon hold potential to gather the large amount of reliable dosage-patient data required for evidence-based personalised medicine, the technology to deliver such data – well-tracked patient/dosing procedures with bi-directional digital information flow – is missing. The PERAMEDIC project proposes to resolve these problems with a breakthrough solution: a stand-alone drug formulation system for personalised medicine, offering locally prepared, individually customised, segmented release polypills, with an inherently digital technology interface. The system relies on integrating several novel technologies: personal release profiles, in situ 3D printing of release matrix using adaptive toolpaths, and ultra-precise multichannel powder dosing of drugs into sealed microcompartments. The envisaged device would be a desktop-size pill/capsule printing machine, using canisters of powdered drugs and bioresorbable polymer matrix material. Application scenarios would be first clinical settings, then at later stage, pharmacy locations and medical practices such as GP’s office. PERAMEDIC will deliver a lab-scale proof-of-concept prototype system of the functionally combined novel technologies, with a preview design of the future technology.

Keywords: personalised medicine,adaptive toolpath,3d printing,pharmaceuticals,polypills,precision dosing,algorithmic design,in line quality control,multimodal metrology,system integration
Microbiota-controlled trafficking of immunosuppressive intestinal T cells into cancer (MADCAM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2487834.0
EU funding (EUR): 2487834.0
Participants: 1
Project status: SIGNED

Resistance of cancers to immune checkpoint blockade (ICB) can result from a deviated taxonomic composition of the intestinal microbiota. A surge in the Enterocloster genus, for instance following discontinuation of antibiotics or chronic inflammation caused by tumors, induces the downregulation of MAdCAM-1 in the ileal lamina propria and mesenteric lymph nodes through perturbations of biliary salts. In turn, the ileal MAdCAM-1 loss induces the exodus of immunosuppressive T lymphocytes expressing the MAdCAM-1 receptor α4β7, i.e., FoxP3+ RAR-related orphan receptor gamma t (RORγt+) regulatory (Tr17) cells, from the gut to distant tumors. Disruption of the MAdCAM-1–α4β7 axis compromises the efficacy of immunotherapy and reprograms the tumor microenvironment towards a regulatory phenotype. Moreover, serum soluble MAdCAM-1 is a proxy of intestinal dysbiosis and a robust predictor of survival in cancer patients treated with ICB. To decipher the biological significance of these findings, we will first investigate the transcriptional and post-translational mechanisms regulating MAdCAM-1 expression and function (Task 1), in particular neuroendocrine and metabolic cues. Next, a comprehensive phenotyping of the emigrating enterotropic T cells reaching the tumor by single cell transcriptomics and genomics, as well as specific genetic and immunopharmacological intervention on T lymphocytes and cancer cells will lead to the identification of the molecular mechanisms regulating the gut-tumor axis (Task 2). We will investigate how enterotropic T cells homing to cancers maintain their proliferative and suppressive capacities, in particular in the light of the recognition of tumor and/or commensal antigens (Task 3). Altogether, this approach will lay the molecular and metabolic foundations governing the MAdCAM-1–α4β7 gut immune checkpoint

Keywords: microbiota,cancer
Women, Violence and the Control of Sexuality in Early Modern Western Mediterranean Armies (VICONS-EMMA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-08-01
End date: 2028-07-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Women's presence in warfare and armies was commonplace in early modern Europe. Whether within armies, in transit areas, military lodgings, permanent military residences, or in besieged cities, it is possible to find their traces. Yet while there are numerous studies of these women’s lives and experiences in central and northern Europe, research for southern European regions remains scarce. This project therefore aims to study the roles and experiences of non-elite women who lived in or came into close contact with armies in sixteenth-century Italy by examining practices, discourses and representations of sexuality and violence. Due to the protracted wars and occupations that unfolded in the Italian Peninsula during the 16th century, the region provides an ideal setting for this research. In particular, VICONS-EMMA will focus on the presence of Spanish soldiers as they provide a crucial perspective for understanding the social impact of both short and long-term military occupations, particularly considering that many Italian states eventually hosted permanent Spanish garrisons. The project employs a mixed methodology, integrating qualitative analysis of legal and theoretical military texts, visual sources and, most importantly, archival records to uncover the voices of these women. This approach will deepen the understanding of sexuality and violence in the complex era of the Reformation/Counter Reformation and open up new debates between Gender and Military History. The project features a major outreach strategy that seeks not only to raise awareness of the importance of women's role in early modern warfare, but also to encourage debate about sexual violence in contemporary military contexts. It will enable the Experienced Researcher (ER) to expand her methodological tools and skills for consolidating a permanent academic position and significantly improve the ER's employability in non-academic job markets such as Public History and historical consultancy.

Keywords: women in war,women in armies,early modern italy,sexuality,military violence,war experiences,sexual violence,gender based violence
Building climate resilience via large scale uptake of systemic solutions in agricultural ecosystems in the Pannonian region (ClimaPannonia)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: Serbia,Hungary,Italy,Germany,Czechia,Croatia,Romania,Slovakia,Switzerland,France
Call: Testing and demonstrating transformative solutions increasing climate resilience of the agriculture and/or forestry sector. (HORIZON-MISS-2023-CLIMA-01, 2023)
Start date: 2025-03-01
End date: 2029-02-28
Duration (months): 48.0
Total project cost (EUR): 6074682.5
EU funding (EUR): 5783991.5
Participants: 25
Project status: SIGNED

ClimaPannonia is the coordinated effort of key stakeholders of the Pannonian Biogeographical Area (PBS) towards strengthening the resilience of the agricultural sector and the region’s community against climate change disastrous effects. This will be achieved by enabling the widest possible uptake of tested and validated climate neutral solutions for four agriculture subsectors: (i) water-food nexus, (ii) agroforestry, (iii) organic crop production, (iv) cattle production. ClimaPannonia aims to support PBA agriculture sector in drastically improving its climate resilience. By implementing innovative systemic solutions and fostering collaboration among the six countries within the PBA – Hungary, Serbia, Croatia, Romania, Czechia, and Slovakia – ClimaPannonia will pave the way for a more sustainable and resilient agriculture. By harnessing the knowledge and expertise of leading experts in PBA and leverage the knowledge of partners from countries such as Germany, Italy, and France, ClimaPannonia seeks to ensure that the solutions implemented are innovative not only at PBA level, but also at European scale.

Keywords: climate change adaptation,pannonian biogeoraphical area
Energy transduction in KInetically asymmetric catalytic NETworks (KI-NET)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1786748.0
EU funding (EUR): 1786748.0
Participants: 2
Project status: SIGNED

Endergonic processes are central to Life. They are achieved by enzymes, that change conformation during their catalytic cycle. Thus, biological non-equilibrium processes are catalysis-driven. The realization of catalysis-driven processes in artificial systems proved challenging. It remains limited to synthetically demanding interlocked structures, which were upgraded with catalytic features affecting ring sliding motion. With KI-NET, I want to develop a general biomimetic strategy enabling endergonic processes driven by chemical catalysis. I plan to invert the current approach by introducing defined conformational freedom into simple catalytic units. KI-NET scientific objectives go beyond state of the art in chemically-driven non-equilibrium systems, with the aim to: (i) establish an unconventional theoretical approach based on “effective transition states”, that guides experiments and reveals common underlying principles for catalysis-driven processes and chemical oscillations; (ii) realize endergonic conformation changes powered by catalytic processes, including ATP hydrolysis; (iii) promote endergonic assembly reactions, that will reveal how energy consumption directs chemical adaptation; (iv) realize an artificial synthase: a catalyst that harvests energy from one reaction and uses it to drive a different one. I will implement a theory-guided experimental approach at the interface between systems chemistry and molecular machines. Leveraging my broad chemistry background, I will address questions that expand towards physics – in terms of formalizing models – and biology – in terms of operating systems to be imitated and unraveled. Realizing KI-NET allows overcoming thermodynamic boundaries. Unforeseen opportunities become possible in material science and energy management, such as the realization of artificial mitochondria. Indeed, KI-NET pioneers a largely unexplored area of science at the roots of dissipative systems, complex phenomena, and –ultimately, Life.

Keywords: systems chemistry,non equilibrium chemical systems,non equilibrium self assembly,chemical reaction networks,molecular machines
AAV9-tRNA-Gly: Towards a first effective therapy for Charcot-Marie-Tooth peripheral neuropathy (tRNAHigh)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-07-01
End date: 2026-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Charcot-Marie-Tooth (CMT) disease is the most common inherited neuromuscular disease, characterized by selective degeneration of peripheral motor and sensory neurons, leading to progressive muscle weakness and wasting, and sensory dysfunction. Currently, no effective, FDA/EMA-approved therapies are available for CMT, necessitating life-long symptomatic treatment. We recently identified the molecular mechanism underlying CMT caused by mutations in glycyl-tRNA synthetase (GlyRS). We showed that transgenic overexpression of the glycyl-transfer RNA (tRNA-Gly) fully rescues peripheral neuropathy in two CMT-GlyRS mouse models. Furthermore, we present preliminary data showing that viral vector-mediated gene transfer of tRNA-Gly administered to newborn, presymptomatic CMT-GlyRS mice fully rescues their peripheral neuropathy phenotypes. In this project we will optimize tRNA-Gly gene therapy, including identification of the optimal viral vector, administration route, and dose to target adult motor and sensory neurons. Next to that, the project will focus on the development of a business roadmap for XtRNA Bio, the spin-out company that I recently co- founded with NLC Health Ventures. XtRNA Bio intends to raise significant pre-seed funding and recruit presonnel, including an experienced CEO who will secure additional funds for continued preclinical and clinical development of tRNA-Gly gene therapy. Finally, once identified, we will patent the optimal gene therapy construct. In all, this proposal constitutes a crucial step towards a first effective therapy for CMT-GlyRS and CMT in general.
Factors In Home and Environment Language Development (FIHELaD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Greece
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-07-31
Duration (months): 26.0
Total project cost (EUR): 153486.72
EU funding (EUR): 153486.72
Participants: 1
Project status: CLOSED

Intra-European migration has populated the school classrooms of mainstream education in Europe’s countries with multilingual students. In European primary schools, typical classrooms include bilingual children of Greek descent who speak Greek as their home language in Germany and bilingual children of German descent who speak Greek as their environment language in Greece. For these pupils being competent in both the home and environment language is pivotal for school achievement. Notwithstanding the large number of studies on the interplay of language systems in the human mind, the fundamental question of language development in multilingualism has yet to be addressed sufficiently: How do linguistic and extra-linguistic person-level factors predict the acquisitional outcome of both the home and the environment language in multilingual classroom populations? The proposed Factors In Home and Environment Language Development (FIHELaD) project addresses this question from an interdisciplinary approach bringing together multilingualism and developmental psycholinguistics along with didactics and data science. This project makes incremental progress towards the goal of advancing the scientific understanding regarding language acquisition and processing and feeding back into society those answers that inform citizens of the beneficial state-of-affairs of multilingualism. FIHELaD is a comprehensive project examining how linguistic and extra-linguistic factors shape the parsing routines of grammatical phenomena with complex syntactic structure, specifically focus sentences, in the home and environment language of 150-200 Greek-German bilingual children. To predict future language development trajectories via statistical modelling, FIHELaD triangulates a unique experimental methodology by combining gaze and pupillometry eye tracking data with classroom-based and baseline experimental observations.

Keywords: psycholinguistics bilingualism heritage language acquisition minority language majority language immigrants sentence processing teaching methodology statistical modelling syntax focus