Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
REcreating the ideal Niche: environmental control Of cell Identity in Regenerating and diseased muscles (RENOIR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Italy,Israel,Italy,Italy,Hungary,France,France,France,France,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-05-01
End date: 2025-04-30
Duration (months): 60.0
Total project cost (EUR): 3482325.18
EU funding (EUR): 3482325.1799999997
Participants: 14
Project status: SIGNED

RENOIR is a European Training Network that brings together 12 beneficiaries (10 academic and 2 industrial), and 3 partner organizations (a private Onlus Foundation, a pharmaceutical company, and a university) to train 13 Early Stage Researchers with an interdisciplinary profile for outstanding carriers as leaders in the field of muscle regeneration and aging. Receiving a training programme in both scientific and transferable skills and using unique expertise and tools at the frontier between biology and engineering, this new generation of versatile researchers will dissect the cellular and molecular mechanisms underlying impaired muscle composition and function, paving the way to new therapeutic interventions for muscle disease and aging. This will happen through collaborative and synergistic projects between academia and industry.

Keywords: muscle regeneration,innate immunity,host microenvironment,cell identity,epigenetics,biopharma,biomaterials,microfluidics,live imaging,bioinformatics
A commercial device for mercury isotope monitoring (MIMO) (MIMO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-05-01
End date: 2016-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Mercury (Hg) is a toxic element with adverse effects on humans and wildlife. Cross-border export of atmospheric Hg emissions makes Hg a global pollutant. In 2013 the UNEP Minamata Convention on Mercury was signed by over 100 countries and aims to reduce future Hg emissions. Implementation of environmental Hg policy requires environmental monitoring efforts. Hg monitoring networks such as GMOS and AMNet typically gather data on atmospheric Hg concentrations, but do not provide information on the Hg emission source. In the ERC StG MERCURY ISOTOPES we have developed dual Hg isotope signatures as fingerprints for Hg sources and transformations. Our observations suggest that most, but not all, anthropogenic Hg emission sources are isotopically distinguishable. The goal of the ERC POC MIMO project is to develop, together with Tekran Inc., the largest global Hg instrument developer, a commercial Mercury Isotope MOnitor (MIMO) that is compatible with current Hg monitoring equipement and programs. Successful development of the MIMO will generate (a) patent(s), drive sales of MIMO and consumables, opens up worldwide opportunities for environmental monitoring companies, and addresses a globally important societal issue.

Keywords: mercury,environment,emissions,monitoring,commercial,isotopes,sources,anthropogenic
Stalling the Replication Fork via the Impedimental Stabilization of Higher-order DNAs (STARFISH DNA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Cancer is a generic term for a group of diseases characterized by the uncontrolled growth and spread of cells with abnormal proliferating activity. Most of the anticancer drugs currently used in the clinic trigger irreversible DNA damages and thus, promote replicative stress. As an alternative of irreversible DNA strand breaks, the non-covalent small-molecule stabilization of unusual, non-B DNA structures has emerged as a promising way to create DNA damages. One of such non B-DNA structures is a three-way DNA junction that might fold both upstream and downstream of the replication fork. The stabilization of three-way junctions by small molecules therefore opens a promising way to induce replicative stress in a highly cancer-specific manner. The main goal of the project "STARFISH DNA" (for "Stalling the Replication Fork via the Impedimental Stabilization of Higher-order DNAs") is to identify a new series of compounds capable of creating DNA damages through three-way junction stabilization and to use them either as standalone therapeutic agent to fight against cancers or in combination with established drugs that disrupt cancer signaling pathways in a synergistic manner.

Keywords: cancer,dna damage response,replicative stress,cell imaging,three way dna junctions,twj ligand
Development of Polymer Halter for Oil Filters (PolyHalter)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Slovenia
Call: Small business innovation research for Transport (H2020-SMEINST-2-2014, 2014)
Start date: 2015-06-01
End date: 2016-11-30
Duration (months): 18.0
Total project cost (EUR): 724550.0
EU funding (EUR): 507185.0
Participants: 1
Project status: CLOSED

PolyHalter project is a direct response to demands for innovative, cost-effective solution which would allow car manufacturers to install lighter, more efficient and lower-priced engine parts (with smaller number of assembly parts). Development of polymer oil filter halter represents significant technological advance in field of engine parts, giving Polycom access to still-developing niche market and significant advantage over competitors. While aluminium has been gold standard in production of oil filter halters for over 70 years, new polymer oil filter halter will enable the combination of minimum noise level, maximum mass savings and maximum price reduction at the level of which hasn’t been achieved so far. Final product will be positioned as a better, cheaper and more eco-friendly alternative to aluminium oil filter halters which won’t need high volume logistics and will be capable of multifunctioning. Number of components within the product will decrease, as well as possibilities of errors. In order to bring the currently developed prototype of polymer oil filter halter from current TRL 6 to industrial and market readiness, key innovation and commercialisation activities still need to be implemented. Additionally, new process (and injection moulding tools) for injection moulding of polymer filter halters will be further optimized to allow manufacture of up to 20 different types of polymer halters in 5 years after completion of the project, for various industries (automotive industry, compressor manufacturing, electro industry, home appliances industry, aircraft industry and similar). Proposed innovation business project is in line with the work programme topic IT-1-2014: Small business innovation research for Transport.

Keywords: polymer,oil filter,filter halter,automotive industry,thermoplastic,injection moulding,eco friendly
Towards matchbox-size GHz femtosecond lasers for frequency combs generation: ‘a femtosecond laser fabricating a femtosecond laser’ (GigaFemto)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Switzerland
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-03-01
End date: 2019-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Femtosecond laser GHz cavity lasers has enabled a new type of optical frequency comb that have defined a new standard and a universal method for precisely measuring optical frequencies measuring. This quantum leap in metrology unravelled numerous technological innovations, from more precise atomic clocks to unprecedented data-transmission flowrate in telecoms. So far, optical frequency-comb systems remain table-top size and expensive, an impediment for further adoptions of this major technological break-through. Here, we propose a novel concept of monolithic, miniaturized – matchbox size - femtosecond laser GHz cavity, in which all the optical functions are integrated in a same substrate, including active functions requiring active tuning or electro-optics effects. This concept relies on femtosecond laser machining combined with post-processing methods to fabricate this optical cavity and to perform the fine alignment required for proper laser operation. It defines a new paradigm where ‘a femtosecond laser is used to fabricate and tune another femtosecond laser’. Specifically, GigaFemto aim at 1/ demonstrating the first all-in-glass femtosecond GHz cavity, of matchbox size, fabricated and tuned by another femtosecond lasers and 2/ laying the seeds for a commercial exploitation by a spin-off company of our laboratory. The later will include a market analysis and a thorough precompetitive study.

Keywords: optics,femtosecond laser,ghz laser cavity,packaging
AlgaHealth: novel cultivation technologies of unique microalgae strains for high quality of fucoxanthin-based products. (AlgaHealth)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-07-01
End date: 2019-11-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Obesity, diabetes and other metabolic syndromes affect an increasing proportion of the population and pose significant economic burden to healthcare systems. To prevent and treat lifestyle-related diseases, it is not sufficient to use an exclusively pharmacological treatment. Nutrition also plays a critical role. Therefore, researchers began to find safe and effective functional ingredients in food to prevent and treat such diseases. One of these functional ingredients is fucoxanthin - a golden-brown carotenoid found in macro and microalgae. The common method to harvest fucoxanthin is from macroalgae (brown seaweeds), but it is not an acceptable alternative because it is seasonal, not sustainable and allows to the extraction of very low quantities of fucoxanthin. The only alternative for a more efficient and sustainable production of fucoxanthin are microalgae. However, existing production techniques of microalgae require high investment and large energy input, preventing large scale and sustainable production. At AlgaHealth we isolated, developed and cultivated new and proprietary microalgae strains of Isochrysis species and novel agro-physiological manipulations to make them grow faster and produce more fucoxanthin. These novel technologies constitute a proven and efficient platform for industrial scale production of high quality fucoxanthin-based oleoresin, at lower energy and environmental-friendly production costs. AlgaHealth is an Israeli biotech company founded in 2017 and stemming from its co-founders’ 20-year experience in microalgae and carotenoids industries. The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of AlgaHealth products and their market uptake.

Keywords: fucoxanthin,isochrysis microalgae species,oleoresin,super critical fluid,low operational costs,sustainability
Continuation of the Cooperation of Space NCPs as a Means to Optimise Services under Horizon 2020 (COSMOS2020plus)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Coordination and support actions
Countries involved: Iceland,Ukraine,Italy,Germany,Cyprus,Switzerland,Belgium,Lithuania,Slovakia,Slovenia,Serbia,Tunisia,Türkiye,Bulgaria,Greece,Poland,Georgia,Latvia,France,Czechia,Portugal,Portugal,United Kingdom
Call: Cooperation among NCPs (H2020-IBA-SPACE-NCP-2018, 2018)
Start date: 2019-06-01
End date: 2021-12-31
Duration (months): 31.0
Total project cost (EUR): 600000.0
EU funding (EUR): 600000.0
Participants: 24
Project status: SIGNED

COSMOS2020plus is the next funding phase of the Space NCP network after COSMOS2020. For participants of Horizon 2020 Space the project will allow to continue organising information days, providing a newsletter service and a website. To improve the performance of single Space NCPs exchange means and trainings will be performed. Through this the overall performance of NCP services should be improved.

Keywords: awareness raising,partner search support,information provision,information days,national contact points for space
Practical Imaging and Inversion of Transient Light Transport (ECHO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2018-12-01
End date: 2023-11-30
Duration (months): 60.0
Total project cost (EUR): 1525840.0
EU funding (EUR): 1525840.0
Participants: 1
Project status: SIGNED

The automated analysis of visual data is a key enabler for industrial and consumer technologies and of immense economic and social importance. Its main challenge is in the inherent ambiguity of images due to the very mechanism of image capture: light reaching a pixel on different paths or at different times is mixed irreversibly. Consequently, even after decades of extensive research, problems like deblurring or descattering, geometry/material estimation or motion tracking are still largely unsolved and will remain so in the foreseeable future. Transient imaging (TI) tackles this problem by recording ultrafast optical echoes that unmix light contributions by the total pathlength. So far, TI used to require high-end measurement setups. By introducing computational TI (CTI), we paved the way for a lightweight capture of transient data using consumer hardware. We showed the potential of CTI in scenarios like robust range measurement, descattering and imaging of objects outside the line of sight – tasks that had been considered difficult to impossible so far. The ECHO project is rooted in computer graphics and computational imaging. In it, we will overcome the practical limitations that are hampering a large-scale deployment of TI: the time required for data capture and to reconstruct the desired information, both in the order of seconds to minutes, a lack of dedicated image priors and of quality guarantees for the reconstruction, the limited accuracy and performance of forward models and the lack of ground-truth data and benchmark methods. Over the course of ECHO, we will pioneer advanced capture setups and strategies, signal formation models, priors and numerical methods, for the first time enabling real-time reconstruction and analysis of transient light transport in complex and dynamic scenes. The methodology developed in this far-reaching project will turn TI from a research technology into a family of practical tools that will immediately benefit many applications.

Keywords: computing methodologies computational photography comp methodologies 3d imaging,comp methodologies image representations comp methodologies ray tracing comp,methodologies reflectance modeling
Spectral Theory of Non-Selfadjoint Markov Processes with Applications in Self-Similarity, Branching Processes and Financial Mathematics (MOCT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Bulgaria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 128994.0
EU funding (EUR): 128994.0
Participants: 1
Project status: CLOSED

The project contextually sets up a novel framework to study the spectral-theoretical properties of classes of non-selfadjoint (NSA) operators related to Markov processes (MP) via their intertwining to a continuous path selfadjoint (SA) MP. Conceptually, this means that the jumps of each class of NSA MP can be considered a perturbation of one SA MP realized by an intertwining kernel. This approach can have far-reaching consequences for understanding classes of MP as the reduction to SA MP leads to well-studied objects whereas the spectral theory of NSA operators is far from understood. The price of that is the non-invertability of the intertwining kernels. This framework is explored and crystallized by a challenging, detailed spectral-theoretical study of an enormous class of NSA operators directly arising from the key phenomenon of self-similarity and in duality from branching. This is achieved by a synergy of research fields complementing each other to obtain the spectral properties of those operators culminating in the derivation of spectral expansions of the generated semigroups. As a result of this synergy, a number of tools and techniques with impact, including applications to fields beyond the scope of the project, are derived. A particular development in the area of recurrent equations and special functions will be unexpectedly exploited to the effect of a comprehensive theoretical and applied study, including numerical schemes, of key quantities in financial and insurance mathematics such as Asian options and perpetuities. A training-through-research in line with the fellow’s affiliation to the host institution and the proposed secondment will critically contribute to the optimal completion of the proposal in terms of time, scope and quality.

Keywords: probability theory,markov processes,branching processes,spectral theory,spectral expansions,exponential functionals,asian options,perpetuities
Extreme Citizen Science: Analysis and Visualisation (ECSAnVis)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-11-01
End date: 2022-07-31
Duration (months): 69.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The challenge of Extreme Citizen Science is to enable any community, regardless of literacy or education, to initiate, run, and use the result of a local citizen science activity, so they can be empowered to address and solve issues that concern them. Citizen Science is understood here as the participation of members of the public in a scientific project, from shaping the question, to collecting the data, analysing it and using the knowledge that emerges from it. Over the past 3 years, under the leadership of Prof. Muki Haklay, the Extreme Citizen Science programme at UCL has demonstrated that non-literate people and those with limited technical literacy can participate in formulating research questions and collecting the data that is important to them. Extreme Citizen Science: Analysis and Visualisation (ECSAnVis) takes the next ambitious step – developing geographical analysis and visualisation tools that can be used, successfully, by people with limited literacy, in a culturally appropriate way. At the core of the proposal is the imperative to see technology as part of socially embedded practices and culture and avoid ‘technical fixes’. The development of novel, socially and culturally accessible Geographic Information System (GIS) interface and underlying algorithms, will provide communities with tools to support them to combine their local environmental knowledge with scientific analysis to improve environmental management. In an exciting collaboration with local indigenous partners on case studies in critically important, yet fragile and menaced ecosystems in the Amazon and the Congo-basin, our network of anthropologists, ecologists, computer scientists, designers and electronic engineers will develop innovative hardware, software and participatory methodologies that will enable any community to use this innovative GIS. The research will contribute to the fields of geography, geographic information science, anthropology, development, agronomy and conservation.

Keywords: citizen science,traditional ecological knowledge,indigenous knowledge,geographical information system usability,ict for development,geographic information science