Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Investigating inflammatory signaling by combining phospho- and ubiquitin proteomics with CRISPR/Cas9 technology (Cytokineproteomics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Deregulation of pro-inflammatory cytokine signalling is the underlying cause for many inflammatory diseases. Thus, understanding the molecular mechanism of cytokine signalling is necessary to develop suitable therapies. The enormous complexity of cytokine cascades has however impeded the development of new therapies. To shed more light into these intertwined signaling cascades, I plan to use a proteomics approach that allows the identification of signalling mechanisms in a multi-dimensional and unbiased fashion. The recent development of the EasyPhos protocol in the Mann laboratory will allow me to take an unprecedented look at phosphorylation events occurring in cells stimulated by single and by combinations of disease relevant cytokines. Simultaneously I will be able to detect changes in the ubiquitinome using the di-Gly enrichment strategy. By combining phosphoproteomics and ubiquitin proteomics with the CRISPR/Cas9 technology to delete and modify members of diverse signaling pathways, I will be able to analyze the role of these players and their post translational modifications in the respective signalling pathways. This study will therefore investigate the mechanisms and the relationship between phosphorylation and ubiquitylation in cytokine signalling in an unprecedented way and has the potential to result in the identification of new therapeutic strategies for the treatment of a range of inflammatory diseases.

Keywords: mass spectrometry,cytokine,phosphorylation,crispr technology
Mental Health promotion of cobot Workers in Industry 4.0 (MindBot)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Italy,Italy,Croatia,Croatia,Belgium
Call: Mental health in the workplace (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2023-09-30
Duration (months): 45.0
Total project cost (EUR): 3919863.75
EU funding (EUR): 3908863.75
Participants: 9
Project status: SIGNED

MindBot aims at identifying methods and implementing solutions for promoting good mental health in the emerging industry 4.0 within the specific context of manufacturing small and medium-sized enterprises (SMEs) that adopt collaborative robots (cobots) in their production lines. MindBot idea is to design workplaces where level of challenge and difficulty of job tasks are matched with the workers’ abilities and skills, in order to support motivation and engagement of workers interacting with cobots in a flexible and personalized way. This will facilitate an active and positive attitude of the worker that promotes good mental health and prevents negative experiences of anxiety or boredom and apathy that eventually lead to mental illnesses. A multidisciplinary approach will be adopted by taking into account multiple facets potentially impacting mental health and intervening on technological, relational and organizational aspects of the cobot-based work. MindBot involves a major worldwide cobot manufacturer, SMEs (employers and employees), universities, technical and clinical research centers, patient organizations and ministry of labour and pension system. The key expected results are: 1.The definition of organizational guidelines for the design of a cobot-based manufacturing workplace able to promote workers’ mental health; 2.The definition of technical guidelines for the design of a “mental health friendly” cobots, including the MindBot prototype development; 3. The definition of an employment model for persons diagnosed with autism spectrum disorders (ASD) working in the frame of manufacturing SMEs adopting cobot.

Keywords: mental health,cobot
An Integrated Collaborative Platform for Managing the Product-Service Engineering Lifecycle (ICP4Life)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Spain,Italy,Germany,Greece,Poland,Greece,France,Netherlands,Luxembourg
Call: Innovative Product-Service design using manufacturing intelligence (H2020-FoF-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 4924693.0
EU funding (EUR): 4924693.0
Participants: 12
Project status: CLOSED

The European manufacturing industry faces new challenges, which are currently not addressed by today’s products and systems. Most of the products are still in essence ‘simple’ in nature, with no capability for adapting to the consumers’ needs and no integrated methods exist for the holistic acquisition and processing of feedback information emanating from product-services. ICP4Life proposes an integrated, collaborative platform for the design, development and support of product-service systems for SMEs, equipment manufacturers and energy suppliers in order to maximize the impact in the European industry. The proposed platform comprises of three main components. The first component demonstrates a collaborative web-based application for the creation and management of products and services by engineers and designers of multiple disciplines. The second component is a Product-Service configuration tool for customers, enabling the easy and intuitive formation of Products and Services. The same component will be used for managing product related data pertaining to the manufacturer, supplier and the customer. The third component will support the efficient, adaptive and responsive planning and decision making phases, for managing the dynamic operation of the plants and the supply chain. All the components will be compatible with open standards, such as AutomationML, in order to make the most out of and accelerate the adoption by the European industry. The ICP4Life project will address the current needs of today’s manufacturers, providing faster design of modular equipment and components, the seamless collaboration of engineers across a wider network of companies as well as within a single company with disperse engineering offices and production sites and the reuse of knowledge regarding both products and processes for new projects or the configuration of existing lines. The ICP4Life consortium consists of highly skilled organizations to ensure the success of this project.

Keywords: machine tool service,energy,product lifecycle
Glacial Legacy on the establishment of evergreen vs. summergreen boreal forests (GlacialLegacy)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-11-01
End date: 2024-10-31
Duration (months): 72.0
Total project cost (EUR): 1979052.5
EU funding (EUR): 1979052.0
Participants: 1
Project status: SIGNED

Boreal forests provide critical ecosystem services to humanity, including timber supplies, cli-mate-regulation, and permafrost-stabilization. However, these forests differ markedly between Asia, which is dominated by summergreen larch forests, and North America, where boreal for-ests are exclusively evergreen. The basic mechanisms controlling the distributions of these bo-real biomes remain poorly understood. My new hypothesis is that summergreen and evergreen needle-leaf forests represent alterna-tive quasi-stable states that occur today under similar climatic conditions, but were triggered by different environmental conditions and gene pools during the Last Glacial. GlacialLegacy will use coherent empirical and modelling approaches to investigate this hypoth-esis across the entire Northern Hemisphere, also collecting new data from northern Asia, where both forests types occur today. Work package (WP) A will explore the dependency of post-glacial forest establishment on the glacial climate and genetic characteristics of northern tree refugia. We will use ancient DNA analysis of sediments, complemented by results from pollen data synthesis. For a mechanistic understanding of the empirical evidence obtained, we will simulate post-glacial forest migra-tion using the LAVESI individual-based vegetation model, into which long-term genetic process-es will be incorporated. WP-B will further refine the LAVESI model using results from vegetation and biophysical field surveys. This will enable us to quantify the vegetation–fire–permafrost–climate feedbacks that are likely to facilitate boreal forest bi-stability. Such a model configuration is the only way that reliable predictions of the future of boreal for-ests can be made, which will be the objective of WP-C. These predictions will aim to anticipate potentially critical future ecosystem service changes on a continental scale, thus providing the knowledge base required for adaptation strategies to be prepared.

Keywords: ancient sedimentary dna,vegetation modelling
LIGHTCAP: Light, Cognition, Attention, Perception (LIGHTCAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,Switzerland,Switzerland,Belgium,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-03-01
End date: 2024-02-29
Duration (months): 48.0
Total project cost (EUR): 4165704.72
EU funding (EUR): 4165704.7199999997
Participants: 7
Project status: SIGNED

Cognition, Attention and Perception (CAP) are crucial for professional success, core to educational success, essential to productive, safe and healthy functioning. Yet cognition is hard work, attention is fragile, and perception is selective. Recent research has shown that light directly and indirectly helps CAP, in particular via the activation of a recently discovered photoreceptor in the human eye. Light triggers this photoreceptor, but large-scale migration to cities, increased time spent indoors, and our 24-hour economy have impacted on our light exposure. Disturbance of sleep/wake cycles, fatigue and cognitive failure, mood disorders and even cancer pathologies may be the consequences of ignoring findings on human light processing. The urgent message is that light can make or break health, social and cognitive functioning. Given the rapid technological developments in light sources (LED, OLED) and the proliferation of intelligent infrastructures (IOT, data science), we are in a crucial period for the realization of truly human-centered lighting. LIGHTCAP aims to address this challenge by providing a strong, innovative and necessary impulse to our insight in the intricate and complex relationship between light, perception, attention and cognition. The goal of LIGHTCAP is to prepare the next generation of experts able to deliver on the promise of truly intelligent, human-centric lighting. We promise an international, interdisciplinary, cross-sectional and translational training program. It unites experts from neurobiology, cognitive neuroscience, chronobiology, psychology and lighting technology. It will train a generation of researchers who can look beyond the borders of their discipline and understand the implications of their findings for other fields.

Keywords: neuroscience,circadian rhythms,lighting,light design,architecture,daylight,non image forming pathway
Fabrication and assembly automation of TERabit optical transceivers based on InP EML arrays and a Polymer Host platform for optical InterConnects up to 2 km and beyond (TERIPHIC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Italy,Israel,Germany,Germany,Greece,France
Call: Photonics based manufacturing, access to photonics, datacom photonics and connected lighting (H2020-ICT-2018-2, 2018)
Start date: 2019-01-01
End date: 2023-03-31
Duration (months): 51.0
Total project cost (EUR): 5626642.5
EU funding (EUR): 4737468.75
Participants: 6
Project status: SIGNED

Efforts to develop optical interfaces with Terabit capacity for datacom applications have kicked off. A practical path to the Terabit regime is to scale the current 400G modules, which are based (in the most forward looking version of the standards) on 4 parallel lanes, each operating with PAM-4 at 53 Gbaud. Scaling these modules by adding lanes looks simple, but entails challenges with respect to the fabrication and assembly complexity that can critically affect their manufacturability and cost. TERIPHIC aims to address these challenges by leveraging photonic integration concepts and developing a seamless chain of component fabrication, assembly automation and module characterization processes as the basis for high-volume production lines of Terabit modules. TERIPHIC will bring together EML arrays in the O-band, PD arrays and a polymer chip that will act as the host platform for the integration of the arrays and the wavelength mux-demux of the lanes. The integration will rely on butt-end-coupling steps, which will be automated via the development of module specific alignment and attachment processes on commercial equipment. The optical subassembly will be mounted on the mainboard of the module together with linear driver and TIA arrays. The assembly process will be based on the standard methodologies of MLNX and the use of polymer FlexLines for the interconnection of the optical subassembly with the drivers and the TIAs. Using these methods, TERIPHIC will develop pluggable modules with 8 lanes (800G capacity) and mid-board modules with 16 lanes (1.6T capacity) having a reach of at least 2 km. Compared to the 400G standards, the modules will reduce by 50% the power consumption per Gb/s, and will have a cost of 0.3 Euro/Gb/s. After assembly, the modules will be mounted on the line cards of MLNX switches, and will be tested in real settings. A study for the consolidation of the methods and the set up of a pilot assembly line in the post-project era will be also made.

Keywords: low cost terabit transceivers,automated photonic device assembly,low cost photonic packaging,hybrid pic,mass manufacturing of photonic transceivers,receiver optical subassembly100g per lane trans
Stable Halide Perovskite Nanocrystals for Efficient Optoelectronic Devices (StabPerov)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

Perovskites have shown impressively outstanding performance in solar cells and light emitting diodes (LEDs) but are still limited by the non-negligible stability issues. With high efficiency achieved, now it is time to fill the research gap for pursuing stable perovskites. My priority goal for the StabPerov project is to obtain highly stable perovskite nanocrystals by using amphiphilic molecules such as liposomes. Upon successful realized, more stable optoelectrical devices can be explored targeting one of the most serious concern for commercialization of perovskite based applications. At the beginning of my project, I will optimize the synthesis of perovskites nanocrystals. For coating perovskites, amphiphilic molecules are used as coating materials. The amphiphilic molecules may also function as ligands. Different types of amphiphilic molecules will be introduced. Detailed and comprehensive characterizations of (HR)TEM, XRD and optical spectroscopy of materials will be carried out before and after degradation. The stability improvement of perovskite nanocrystals is now urgent, whilst getting the insight of how perovskites are decomposed is also necessary with regard to optimize synthesis and to evaluate protected nanocrystals. At the next stage, the as-prepared high quality stable perovskite nanocrystals will serve as emitters and catalysts for the demonstration of applications. My results are of great feasibility and practical significance, which pave the way towards the applications of stable high performance perovskite based devices. Combining my background with the training of optical spectroscopy offered by the host as well as being an independent investigator of this project, the Marie Curie fellowship will not only provide an excellent chance for me to become a research group leader in my future career, but also offer a markedly benefit to the development of sustainable energy for society by more efficient and more stable solar cells and LEDs.

Keywords: perovskite,nanocrystals,stability,synthesis,photoluminescence,amphiphilic molecule
Seismic Plus EneRgy Upgrading of Masonry Buildings using Advanced Materials (SPEctRUM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-12-01
End date: 2020-11-30
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

This project aims to develop innovative techniques integrating advanced materials for the simultaneous seismic and energy retrofitting of the European masonry building stock. Upgrading the existing masonry EU buildings is becoming progressively more important due to: (1) their poor seismic performance during recent earthquakes (i.e. Italy, Greece) that have resulted in significant economic losses, severe injuries and loss of human lives; and (2) their low energy performance which increases significantly their energy consumption (buildings are responsible for 40% of EU energy consumption). Since replacing the existing buildings with new is prohibitively expensive and has also huge environmental and social impact, their lifetime extension requires considering both seismic and energy retrofitting. It is noted that the annual cost of repair and maintenance of existing European building stock is estimated to be about 50% of the total construction budget, currently standing at more than €300 billion. To achieve cost effectiveness, SPEctRUM explores a novel approach, proposing for the first time a hybrid structural-plus-energy retrofitting solution which combines inorganic textile-based composites with thermal insulation systems for masonry building envelopes. The effectiveness of the proposed retrofitting system will be validated experimentally and analytically. Moreover, a common approach for the buildings performance classification will be proposed, allowing to assess whether energy efficiency and disaster-resilient practices should be integrated. Eventually, draft guidelines and recommendations for determining future research design on concurrent seismic and energy retrofitting of EU masonry buildings envelopes will be proposed.

Keywords: seismic retrofitting,energy retrofitting,composite textiles,masonry buildings,advanced materials,construction
Functions and evolutionary impact of transcriptomic novelties in the vertebrate brain (NEURAL AS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Spain
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2020-12-31
Duration (months): 69.0
Total project cost (EUR): 1498852.0
EU funding (EUR): 1498852.0
Participants: 1
Project status: CLOSED

Alternative splicing (AS) is the largest contributor to transcriptomic diversification in metazoans. In particular, mirroring their unparalleled morphological and cellular complexity, vertebrate brains show the highest levels of regulated AS known in nature. However, the functions of most of these alternative transcripts, and the evolutionary impact that the increased transcriptional complexity has had on the evolution of the vertebrate brain are still widely unexplored. In this project, we will investigate the functions and evolutionary impact of neural AS in vertebrates. We will focus on neural-specific alternative exons that are highly conserved across vertebrate groups (suggesting functional importance), but that are not conserved in invertebrates, and are thus vertebrate-specific genomic novelties. We will term these exons Vertebrate- and Neural-specific Alternatively Spliced (VN-AS) exons. Through a combination of bioinformatics, experimental manipulation in models species, and systems-level network analysis, we aim to: (i) Comprehensively identify VN-AS exons, and study their regulation during vertebrate neurogenesis and nervous system development, using RNA-seq and comparative genomics; (ii) Probe the phenotypic impact of VN-AS exons on vertebrate nervous systems, using the CRISPR-Cas technology for genome editing; and (iii) Investigate how VN-AS exons rewire protein-protein interaction networks in vertebrate neurons – an emergent molecular function for AS –, and whether this rewiring underlies novel functions of VN-AS exons in the vertebrate brains. This project will thus deliver fundamental insight into two major unanswered questions: (i) what are the functions of transcriptomic diversification, and (ii) how does transcriptomic diversification impact organismal evolution. Our results will fill a large gap of knowledge in our current understanding of brain evolution and development, providing a complementary angle to traditional gene expression studies.