Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
On Trade Policies and Climate Change (TradePoliciesClimate)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2024-02-25
Duration (months): 24.0
Total project cost (EUR): 175673.28
EU funding (EUR): 175673.28
Participants: 1
Project status: SIGNED

Climate Change and Trade are two examples of public goods that call for international cooperation and coordination. The threats due to changes in climate conditions and the losses potentially due to adverse (or extreme) weather events have induced countries to look for common solutions. Moreover, trade and climate change are not only two global scale issues, but they are also tightly connected: trade is a major economic activity, climate is a major exogenous factor in economic production. Trade and climate change have direct and indirect links: trade impacts climate either through the emissions of the transport industry, and by favoring (or disfavoring) emissions-saving productions; climate change directly impacts trade by modifying comparative advantages, and indirectly by legitimating trade as an adaptation strategy. Trade is fostered by trade policies, which are also tightly connected to the dynamics of climate change. Thus, environmental and trade policies tend to be connected, and research to deepen on these links would be beneficial. The proposed research aims at investigating how climate change influences trade (volumes, values, and patterns) and how trade policies are evolving and are likely to evolve due to climate change. The research will focus on the effects of climate change on trade and trade policies. More precisely, the project intends to achieve the following two goals: (i) analyse the links between, trade and climate change, and quantify the impacts; (ii) investigate the path dependencies in trade, trade regulations and climate change, so to evaluate co-benefits and side-effects of seemingly unrelated policies on climate change and trade. The methodological approach that I will follow stands out against previously adopted methods. I propose an econometric analysis to investigate the links between climate change, trade and policies, and a multidiscplinary approach to better model and interpret these links.

Keywords: agricultural economics,agricultural production,climate change,international policies
Ferroelectric Nanocomposites for Enhanced Solar Energy Efficiency (FENCES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1999903.0
EU funding (EUR): 1999903.0
Participants: 1
Project status: SIGNED

Solar photovoltaics (PVs) and sustainable fuel production from photocatalysis are key technologies to displacing fossil fuel use. However, in order to drive rapid growth in PVs, and the commercial viability of photocatalytic solar fuel production, innovative technological approaches are needed to increase efficiencies while keeping costs low. FENCES aims to demonstrate a new mechanism for solar energy conversion and use this to drive up the efficiencies of these key technologies. This will draw on a phenomenon found in ferroelectrics, known as the bulk photovoltaic (BPV) effect. While this has demonstrated photovoltages above the theoretical limit for conventional PVs, efficiency has remained low due to poor light absorption and charge transport. FENCES will overcome these limitations by intimately combining ferroelectrics and photoactive materials in nanocomposite thin films. This will couple the high electric field from the ferroelectric to the photoactive material, demonstrating novel behaviour with the potential to exceed the performance of current technologies. In order to achieve this, FENCES will: 1. Design and synthesise optimal ferroelectric nanostructures and gain control over their properties, including the BPV effect, through careful study and tuning of the material properties in both precision model systems and low-cost, solution-based materials; 2. Develop detailed device models to accurately describe and predict the behaviour of these novel devices, incorporating progressive knowledge and understanding throughout the project using both empirical data and computational modelling; 3. Use these models to predict the optimum materials, structures and designs to demonstrate this novel technology and optimise device performance; 4. Fabricate and test proof-of-concept devices based on these optimised designs to validate the models and prove the hypothesis, establishing a new frontier in solar energy generation and wider science.

Keywords: ferroelectric,photovoltaic,solution processing,nanocomposite
Understanding and modulating vascular arrest with ultra-high definition (AngioUnrestUHD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 1998500.0
EU funding (EUR): 1998500.0
Participants: 1
Project status: SIGNED

Therapeutic modulation of vascular cell proliferation and migration is essential for the effective inhibition of angiogenesis in cancer or its induction in cardiovascular disease. The current view is that an increase in growth factor levels or mitogenic stimulation is beneficial for angiogenesis, since it leads to an increase in both endothelial proliferation and sprouting. Through the use of innovative genetic and imaging approaches, we have recently elucidated a previously unappreciated, context-dependent mechanism whereby highly mitogenic environments can be detrimental for angiogenesis and lead to the cell-cycle arrest of endothelial cells (ECs), which ultimately impairs vascular growth. The identified mechanism may explain the failed or inefficient promotion of functional angiogenesis by vascular growth factor delivery therapies, such as those used to treat ischemic cardiovascular disease. We propose that a better understanding and modulation of the identified hypermitogenic arrest process may allow angiogenesis to be induced more effectively. Taking advantage of recent advances in DNA synthesis, CRISPR gene editing, microscopy and single-cell profiling technologies, we have developed new genetic tools, animal models and methods of broad relevance that enable the study of gene function with higher reliability, throughput and definition. We propose to use these novel research tools and methods to significantly increase understanding of the biology of blood vessels in distinct physiological and pathological contexts. We will then use this new knowledge to identify better strategies to promote vascular development in ischemic cardiovascular disease, heal vascular malformations, or inhibit angiogenesis in tumours.

Keywords: angiogenesis,vascular biology,endothelial,genetic mosaics,notch
Cellular and molecular mechanisms of remote fear attenuation (Remote memory traces)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2021-10-31
Duration (months): 66.0
Total project cost (EUR): 1494325.0
EU funding (EUR): 1494325.0
Participants: 1
Project status: CLOSED

Traumatic events generate some of the most enduring forms of memories. Despite an elevated lifetime prevalence of related fear and anxiety disorders, effective treatments for traumatic memories are scarce and the mechanisms behind successful memory attenuation poorly understood. This discrepancy is particularly pronounced for remote traumata, when the original insult occurred in the distant past. Here, we propose to identify, isolate to analyze, and causally determine neuronal subpopulations involved in remote fear memory attenuation. To achieve these goals, we will use a combination of transgenic mice with direct in situ manipulations of neuronal subpopulations and cell type-specific transcriptomic and epigenetic profiling. Specifically, we will inducibly and persistently tag neurons activated by remote memory recall, and subsequently capitalize on this tag threefold: First, by visualizing this tag after successful memory attenuation, we will identify neuronal subpopulations that promote remote memory reduction. Second, by using this tag as an anchor for pharmacological manipulations interfering with neuronal activity, we will determine a causal implication of these neurons in successful memory attenuation. Lastly, by employing this tag as bait, we will isolate neuronal subpopulations that promote memory attenuation to analyze their epigenetic regulation of gene expression, a core component of enduring forms of memories. By investigating these mechanisms in three independent protocols for memory attenuation, we seek to provide proof-of-principle that successful memory attenuation is defined by a unique molecular signature, which can serve as a template to better ascertain the potential of other treatments aimed at attenuating remote memories. We expect this project to deepen our understanding of remote traumatic memories and their attenuation at an unprecedented cellular and molecular resolution.

Keywords: ptsd,memory trace,epigenetics,extinction,reconsolidation,exposure based therapy,mouse,psychotherapy,long term memories,transcription,fear conditioning
Dissecting the constraints that define the eukaryotic DNA replication program (REPLICONSTRAINTS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-08-01
End date: 2022-07-31
Duration (months): 72.0
Total project cost (EUR): 1498898.75
EU funding (EUR): 1498898.75
Participants: 1
Project status: CLOSED

DNA replication is essential for the perpetuation of life and, yet, it is also a major source of genomic instability that can lead to cancer and other human diseases. Despite the vast efforts invested in establishing the origins of genomic instability, the mechanisms that coordinate faithful genome duplication while ensuring its integrity remain unknown. This dilemma is molecularly best exemplified by single stranded DNA (ssDNA), which inevitably results from unwinding the double helix due to replication fork progression, but is at the same time a vulnerable intermediate that can lead to severe genomic lesions. Thus, maintaining an appropriate balance of ssDNA is a paramount challenge for replicating cells. My own work has significantly contributed to this concept by showing that eukaryotic cells have limited resources to guard its ssDNA, and that exhaustion of these resources (due to increased overall levels of ssDNA) causes a lethal fragmentation of the genome termed ‘replication catastrophe’ (RC). To prevent this terminal scenario, ssDNA levels and DNA replication activity must be constrained by yet uncharacterized mechanisms. In eukaryotes, where DNA is simultaneously replicated at multiple sites throughout the genome, this represents a particularly challenging task. Understanding how this is molecularly accomplished could transform our view of the very principles of DNA replication regulation, and also reveal potential therapeutic avenues to exploit RC in the treatment for cancer. With the present proposal I will address this challenge by investigating how ssDNA maintenance is enrooted in the regulatory principles of DNA replication. I will dissect the mechanisms that, globally and locally, constrain replication activity to prevent genomic instability. By using novel and innovative analytical tools, I aim to provide an unmatched picture of the DNA replication apparatus and to identify novel anticancer strategies based on provoking RC selectively in tumor cells.

Keywords: dna replication,genomic instability
Enhancing innovation management capacity of SMEs in Republic of Srpska (EUNORS)

Framework: Horizon 2020 — EC Treaty
Action type: Specific Grant agreement
Countries involved: Bosnia and Herzegovina
Call: EEN H2020 SGA2 2D BATCH (H2020-EEN-SGA2-2017-1, 2017)
Start date: 2017-03-01
End date: 2018-12-31
Duration (months): 22.0
Total project cost (EUR): 25065.0
EU funding (EUR): 20052.0
Participants: 5
Project status: CLOSED

Republic of Srpska is one of two constitutive entities within the Bosnia and Herzegovina, and is autonomous in area of economic development. In order to provide stronger support to development of business sector (in particular the SMEs, that account for 99,8% of all businesses in RS), RS has decided to apply for the membership in the EUNORS (EEN RS) will provide SMEs with opportunities to explore their development and innovation potential in cooperation with partners from other EEN countries. EUNORS will strengthen regional cooperation (SEE and EU), and strengthen cluster development. EUNORS will cooperate with RS stakeholders and other institutions providing SME support services. The project aims are supporting SMEs on knowledge bases to bring their ideas to the market and scale up business by developing a innovation structure and implementing to it action plan. The n innovative SMEs will foster interaction among the SMEs actors and ultimately support European countries to gain state of the art technical knowledge and achieve the ability needed to drive innovation to the market Enhanced growth and profitability of 48 SMEs in RS through provision of specialized innovation support services within EUNORS network. Specific objectives: • Enhanced innovation management capacity of 48 companies within 24 months in Republic of Srpska. • Provide key account management support for 8 successful applicants of SME Instrument • Build capacity of 8 experts form Consortium member organizations to handle innovation management capacity assessment and innovation support services provision The implementation of this innovation action will give an SMEs performance model in the knowledge based society and will have a great impact in developing the Republic of Srpska SMEs culture where there is a need to foster SMEs through strengthening innovation capacities and start up acceleration programmes.

Keywords: small and medium enterprise,innovation,research,entrepreneurship,technology,transfer,knowhow
Providing Antifouling Additives for Marine Paints Inspired by Nature and Engineered for Industries (BMX-11)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: SME instrument
Countries involved: Portugal
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 1993750.0
EU funding (EUR): 1395625.0
Participants: 1
Project status: CLOSED

Any object submerged in water is subject to fouling, such as boats, oil drilling platforms and aquaculture equipment. To prevent fouling, companies who own submerged assets use antifouling paints (i.e. the use of antifouling paints is estimated to prevent 25% of fuel consumption of the world fleet). However, 90% of existing antifouling paints are toxic and current solutions are not 100% effective. Plus, the most used antifouling additive – copper - is characterized by high price volatility. Biomimetx has recently discovered a unique bacterium that secretes high levels of molecules that can be used as natural antimicrobials and algaecides. This compound can be produced through an optimized fermentation process (Internationally patented by us) that ensures high yield. The outcome of the Phase 2 project will be the first marine antifouling paint containing a non-toxic antifoulant additive (BMX-11) on the market. BMX-11 is 100% biodegradable, cost effective and fully efficient against all elements of biofouling. We aim to address the global market of biocide additives for marine paints estimated in at least €2.8 billion in 2016. BMX-11 has the potential to be highly disruptive also because it allows the creation of non-toxic paints that can be certified for non-professional use. This means that BMX-11 can enable the DYI market of antifouling paints. Biomimetx was founded in 2013, and our current team of 9 professionals has been awarded 400k€ in Portuguese research grants and 1,8M€ in Venture Capital to pursue the market rollout of BMX-11 and co-finance the present Phase 2 project.

Keywords: antifouling marine paints,blue growth,non toxic,effective,disruptive
Observation-based system for monitoring and verification of greenhouse gases (VERIFY)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Germany,Germany,Austria,Germany,Ireland,Italy,Italy,Switzerland,Norway,Türkiye,Belgium,Finland,Sweden,Russian Federation,Switzerland,Norway,Norway,France,France,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Towards a robust and comprehensive greenhouse gas verification system (H2020-SC5-2017-OneStageB, 2017)
Start date: 2018-02-01
End date: 2022-07-31
Duration (months): 54.0
Total project cost (EUR): 10229338.75
EU funding (EUR): 9998963.75
Participants: 48
Project status: SIGNED

As the negative impacts of rising global temperatures become increasingly evident, national governments, regional authorities and private stakeholders are enhancing efforts to curve down the emissions the greenhouse gases (GHG) responsible for global warming. Measuring the effectiveness of GHG emission reduction policies against agreed-upon international targets require accurate and precise estimates of emissions and their trends. These estimates need to be established and regularly updated using transparent methods, tracable to international standards. VERIFY proposes to quantify more accurately carbon stocks and the fluxes of carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O) across the EU based on independent observations in support of inventories that rely only on statistical data. The same approach will also be tested for US, China and Indonesia, in collaboration with foreign partnes. Accurate characterization of the space-time variations of GHG fluxes, separating their anthropogenic and natural components and their drivers, will be based on advanced modelling approaches using atmospheric GHG measurements, tracer transport inversions and various arrays of land observations, in-situ and from space. The improved knowledge of GHG budgets from VERIFY will be used to improve national inventories, in collaboration with national inventory agencies, and to deliver policy-relevant information to track progress of the EU mitigation efforts to meet the targets of the Paris Agreement on Climate, in line with international cooperation mechanisms promoted by the WMO, the IPCC and the UNFCCC.

Keywords: greenhouse gas emissions,monitoring,reporting and verification mrv,national inventories,ecosystem and atmospheric modelling,assessment,tracer transport inversions,in situ ghg observations
AIRE_ Artificial Intelligence for Recruiting Europe + (AIRE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Ireland
Call: European SME innovation Associate - pilot (H2020-INNOSUP-2019-02, 2019)
Start date: 2019-10-01
End date: 2021-02-28
Duration (months): 17.0
Total project cost (EUR): 98750.0
EU funding (EUR): 98750.0
Participants: 1
Project status: CLOSED

The digital age has permeated our daily lives. The data we consume and create results in analytic processes informing how we work, eat, play, live. Companies need to understand, analyse and develop their Human Capital to remain competitive and future proofed. Present technology is not serving the market effectively. CVs have long outstayed their use for employers and overburden HR systems. EU citizens need to be able to assess their skills versus a changing job market to keep pace; putting them in the best position to successfully be hired. Our innovative approach to solving the bottleneck between jobseekers and job vacancies sets us apart. Our disruptive platform, AIRE, uses AI & Machine Learning to accurately and without bias, match candidates to roles, identify skills gaps for candidates and enable employees to keep their skills relevant in an ever-evolving job market. Our vision will create a scalable solution to empower EU citizens to maximise their career potential. In line with our growth strategy, Allsorter is looking to employ an innovation associate to help us achieve the above goal. The post will be influenced from the domains of textual mining, machine learning and crowdsourcing. This field is novel precisely because it attempts to combine a longstanding promise of AI to improve the quality of hiring, which ability is focused around the use of data to standardize the matching between candidates’ experience, knowledge skills and the job requirements. This improvement in the job matching mechanism will utilize innovative computational methodologies for processing, improving, and disseminating employability patterns.

Keywords: artificial intelligence,innovation,talent management,employment,skills