Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Maritime Low Emission Network (MarLEN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Coordination and support actions
Partnership: ZEWT (co-programmed)
Countries involved: Germany,United Kingdom,Türkiye,Italy,Ireland,Norway,Portugal,Belgium,Romania
Call: Coordinating and supporting the combined activities of member and associated states towards the objectives of the Zero Emission Waterborne Transport partnership so as to increase synergies and impact (ZEWT Partnership) (HORIZON-CL5-2024-D5-01, 2024)
Start date: 2025-01-01
End date: 2029-06-30
Duration (months): 54.0
Total project cost (EUR): 1631885.85
EU funding (EUR): 1542689.42
Participants: 15
Project status: SIGNED

MarLEN (Maritime Low Emission Network) will be a partnership of European ministries and funding organisations responsible for funding RTD in maritime technologies from European countries. The objective of this initiative is to strengthen the European Research Area in waterborne research by coordinating and developing synergies between national and regional maritime research programmes and policies in line with the aims of the partnership Zero Emission Waterborne Transport (ZEWT). The activities will include: exchange of information and knowledge among national programme owners and programme managers as well as the implementation of distinct joint activities. MarLEN shall further deepen, broaden and strengthen the already established transnational cooperation based on the experience gained and some existing cooperation structures. New organisations from several partner countries will broaden the network of maritime ministries and funding organisations with the knowledge of former initiatives. Lessons learnt especially from the previous MarTERA project are taken into account in this proposal, aimed at improving and intensifying the transnational cooperation and, most importantly, consolidating it in such a way that it becomes self-sustaining. Further objectives are the broadening, deepening, streamlining and strengthening of the joint activities, including strengthening the existing ongoing trans-national research to cover the whole innovation chain from science to business by launching new transnational activities. However, to fulfil the ambitions of the waterborne transport sector, it is obvious that much more research, development, innovation (RD&I) and investments will be necessary in the coming years to address and respond effectively to the current and future climate and environmental challenges, while taking into account a safe implementation of technologies and concepts.

Keywords: maritime technologies,zero emission waterborne transport
Multivalent Supramolecular Nanosystems as Dynamic Virus Blockers (SupraVir)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2849138.0
EU funding (EUR): 2849138.0
Participants: 1
Project status: SIGNED

Background: Viral pandemics pose great risks to current and future human health and global trade. Newly emerging viruses can display a broad variety of shapes, such as spherical or filamentous, and spike proteins have different lengths and densities, as seen in coronaviruses and influenza viruses. Viruses can mutate rapidly under evolutionary pressure, resulting in changes to antigen epitopes and reduced efficacy of drugs and vaccines. These variances between viruses and across mutations present challenges to broad-based anti-infection intervention and vaccination. However, the initial docking of viruses to cell surface receptors via heparan sulfate or polysialic acids are common for a number of viruses, offering an attractive target for wide-reaching intervention. Aim: The SupraVir project will provide a new concept for multivalent supramolecular assemblies as self-adaptive universal virus blockers. This new type of virus inhibitor can adapt to different virus morphologies and mutations by dynamic self-assembly of its virus binding sites. The inhibitor will use a combination of different receptors and bind a great majority of all known viruses by mimicking generic host cell surface receptors. Methodology: My approach will use self-assembled surface-active supramolecules that mimic the host cell surface efficiently and dynamically. With this method I will avoid a bulk phase that does not contribute to the activity, thus reducing potential toxicity. At the same time, the amphiphilic building blocks can interfere with the viral envelope or capsid and permanently inactivate the virus. Impact: SupraVir addresses the central question: What might prevention of viral infections look like in 2030? I contend that there is a new option, based on mimicking dynamic cell surface receptors with multivalent supramolecular nanosystems that can self-adapt to inactivate rapidly mutating viruses.

Keywords: multivalency,supramolecular polymers,synthetic virus inhibitors
An RNA aptamer-based tool for the detection of pathological protein aggregates in biofluids (AptALS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-01-01
End date: 2027-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The AptALS project aims to develop a highly sensitive and scalable RNA aptamer-based kit for detecting TDP-43 aggregates, a key biomarker in ALS. The kit consists of 3 main components: (i) biotinylated RNA aptamers that selectively bind aggregated TDP-43, (ii) a detection system (fluorescence or chemiluminescence) to quantify binding events, and (iii) a modular assay format compatible with ELISA-like workflows, allowing seamless integration into clinical laboratories. By leveraging our patented aptamers, we will validate their performance in a standardized detection assay, ensuring clinical robustness. Unlike conventional antibody-based methods, RNA aptamers offer superior specificity and adaptability, enabling non-invasive, early-stage ALS detection. This innovation fills a critical gap in ALS diagnostics, replacing invasive lumbar punctures and costly neuroimaging with a cost-effective, scalable alternative. The AptALS project will focus on three key objectives: (i) assay validation, (ii) optimization of detection methods (fluorescence vs. chemiluminescence), and (iii) benchmarking with ALS patient samples. The project is led by a multidisciplinary team with expertise in biophysics, molecular biology, and computational modeling, supported by IIT’s state-of-the-art genomics, proteomics, and microscopy facilities to ensure technical rigor and scalability. Beyond its scientific impact, AptALS delivers significant societal and economic benefits. Early ALS detection can enable timely intervention, improve patient care, and reduce healthcare costs. The diagnostic kit is designed for B2B distribution, targeting hospitals, diagnostic laboratories, and pharmaceutical companies for clinical trials and patient stratification. Positioned at the forefront of neurodegenerative disease diagnostics, AptALS is poised for strong commercial adoption, bridging the gap between research and real-world clinical application, fostering innovation, and advancing ALS care.
Young galaxies as tracers and agents of cosmic reionization (AGENTS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1498216.0
EU funding (EUR): 1498216.0
Participants: 1
Project status: SIGNED

The identification of the first galaxies in the early Universe has been an expanding frontier of observational astrophysics. Reionization marks the last major phase transition of matter in the Universe and its completion had crucial impact on the formation of the smallest galaxies. Reionization is therefore the first landmark of the influence that feedback from star formation had on structure formation. While reionization roughly encapsulated the first Gyr of cosmic time, the precise timing, topology and the sources of ionizing photons are unknown. Did reionization proceed rapidly or gradually and was it driven by rare bright galaxies, or numerous faint ones? The main limitation to our understanding is our little knowledge of the properties of galaxies in the early Universe. Now, thanks to the long-awaited James Webb Space Telescope (JWST), this field can transition into the study of the characteristics of these first galaxies and the assessment of their impact on their environment. With its new technical capabilities, JWST will enable the identification of thousands of faint galaxies in the early Universe and enable the measurement of the detailed properties of their stellar populations and interstellar medium. My StG will benefit from my early access to JWST to obtain a complete census of the young galaxy population with emission-line surveys in the first 3 Gyr of cosmic time. I will use unprecedented observational techniques in survey fields that enable direct measurements of the connection between galaxies and intergalactic gas. Based on a multi-angled approach, I will assess the role of young galaxies as agents and tracers of reionization. My team will measure the total ionizing budget from young galaxies in the early Universe and self-consistently trace the topology and timing of reionization on global and local scales. This project will yield a legacy that paves the way for future endeavours with the Extremely Large Telescopes and the Square Kilometre Array.

Keywords: high redshift galaxies,intergalactic medium,reionization,emission line galaxies,early universe,lyman alpha emission
Single-cell and live-imaging approaches to study Intra-tumor Heterogeneity and Population Dynamics in Colorectal cancer organoids (POPYNA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

Colorectal cancer (CRC) is one of the most diagnosed cancer worldwide. Though several treatment strategies are available today, around a million people die of this disease each year worldwide. Thus, there is still a pivotal need for new and more effective treatments. Intra-tumor cellular heterogeneity has emerged lately as an intrinsic feature of malignancies and as one of the factors responsible for therapy resistance or tolerance. However, the role that phenotypically distinct subpopulations have on tumor biology is far from being understood. This multi-disciplinary proposal is based on the use of cutting-edge techniques to unravel the basic features of intra-tumor phenotypic heterogeneity and subpopulations interactions. The goals are to (1) identify and characterize phenotypically distinct subpopulations on a set of metastatic CRC human-derived organoids by single-cell RNA sequencing; (2) monitor their plasticity (transitions) by generation of fluorescent reporter lines and live-imaging lineage tracing; (3) study the impact of each subpopulation on tumor growth, and identify underlying molecular pathways by live-imaging. Ambitiously, this project aims at witnessing phenotypic transitions in living cells, a challenging task that has not been fully accomplished yet, with relevant therapeutic consequences. It is expected that this project will provide the scientific community with a deeper understanding on subpopulations dynamics in colorectal cancer, that could ultimately result in the discovery of novel treatment strategies, such as targeting a specific subpopulation or interfering with molecular determinants of transitions. Moreover, it will foster the independent career of the applicant as a researcher by expanding her skills and international network. This project tackles a relevant problem of modern cancer biology by employing innovative techniques, complemented with state-of-the-art facilities and high quality training and mentoring.

Keywords: intra tumor heterogeneity,scrnaseq,quantitative live imaging,population dynamics,cancer,organoids,plasticity
Decoding hidden drivers of recurrent evolution in plants through the inference of amino acid ages. (RecAminoAge)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-04-01
End date: 2028-03-31
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

Plants constantly face environmental challenges, impacting ecosystem stability, promoting new pathogens and compromising food security. A fundamental question in evolutionary biology is whether repeated adaptations, driven by similar environmental pressures, rely on the same genetic programs, especially over long timescales. Protein sequences, increasingly available across diverse lineages, offer a unique opportunity to tackle this issue on an unprecedented scale. However, as evolutionary divergence increases, current methods result in substantial information loss and an inherent bias due to reliance on a single optimal alignment configuration. This, in turn, makes it difficult to identify which substitutions among billions could convergently alter adaptive phenotypes. To overcome these challenges, I will establish a novel framework for inferring common evolutionary origins by incorporating suboptimal alignment configurations. Summarized as “amino acid ages”, I will date protein substitutions in a ladder-like fashion until a substitution is no longer stable in the suboptimal alignment space. The taxonomic level of the detected substitution will indicate the evolutionary origin/age of an amino acid within a protein. I hypothesize that amino acid ages capture emerging nuances missed in divergent lineages since suboptimal configurations may expose hidden evolutionary constraints. First, I will develop a fast and scalable computation of amino acid ages for community use. Second, I will generate a resource containing amino acid age annotations for all available plants. Third, I will establish associations between candidate protein substitutions that lack assigned ages, not acquired through common ancestry, and recurrent adaptive traits. RecAminoAge will provide the community with a disruptive methodology that sheds light on protein evolution rates over long timescales while enhancing predictions of species retaining valuable adaptations to tackle future challenges.

Keywords: protein evolution,optimal alignment bias,amino acid ages,database,parallel evolution
singlet fission non-conjugated polymeric photovoltaic materials fabrication (SFPOLY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-02
End date: 2027-06-01
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

On the path to enhancing photovoltaic (PV) materials and surpassing their efficiency limits, one promising approach is to exploit the phenomenon of singlet fission (SF). This process involves high-energy singlet excitons generated by light absorption in organic molecules, which interact with nearby ground-state molecules to produce two triplet excitons. This intricate interaction significantly boosts the efficiency of photovoltaic devices. Given the scarcity of SF materials and the advantageous properties of polymers in PV applications, this project aims to address the challenge by employing advanced polymer synthesis techniques. The project’s hypothesis centers on designing monomers inspired by known singlet fission small molecules. The following steps involve utilizing controlled polymerization strategies to create polymers with various topological structures. These polymers will be combined with PbS quantum dot materials to produce composite films with SF properties through spin coating. By adjusting the polymer topology to fine-tune the stacking configuration of the polymer chains, the photophysical properties of the materials can be precisely controlled. Through detailed analysis of these photophysical properties, the relationship between polymer structure and photophysical behavior will be established. Ultimately, this will lead to the development of a new generation of composite singlet fission photovoltaic materials, enabling the creation of high-performance photovoltaic devices that surpass the theoretical limits of traditional photoelectric conversion efficiency. Through advanced polymer synthesis, precise photophysical analysis, and fine-tuned thin-film optimization, this research will unlock the potential of singlet fission, significantly impacting polymer materials. It will pave the way for new photovoltaic materials, contributing to clean energy and promoting environmental sustainability.

Keywords: singlet fission,step growth polymerization,polymer topology,photovoltaic materials
Infrastructures of Expulsion: Migrant Deportation and Policing in India (InfraExpulsion)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2026-10-31
Duration (months): 38.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

The unfolding migrant crisis in Afghanistan has once again turned the focus on ‘neighbouring’ countries as key locations where EU policies seek to enhance migrant hosting capacity. Yet, research on South-South migration and regional modes of prevention, detention, and deportation of ‘illegal’ migrants remains limited. Taking the case of India, my project aims to contribute such knowledge by addressing a central paradox in migration regulation i.e., why, despite the proliferation of increasingly stringent forms and modes of migrant policing, do state anxieties regarding the detection and deportation of ‘illegal’ migrants continue to thrive? My project’s original hypothesis is that this paradox stems from the contingent stitching together of social, material, and biometric forms of policing that involve a range of formal and informal actors, spaces, and processes in unpredictable ways. In conceptualising the uneven intermeshing of social, material, and biometric policing as infrastructures of expulsion, I will analyse how the variation in forms of deportation policing produces precarity for migrants whilst engendering governance challenges. Empirically located in Delhi, my project will achieve its goal through anthropological methods of ethnography, participant observation, and interviews that will document practices of deportation policing in a residential neighbourhood, police station, and detention centre, and its impact on African and South Asian migrants. Hosted in the leading Max Planck Institute for Social Anthropology, the project will aid my scientific and professional training, specialisation in migration and governance, and career growth as an independent researcher. Insights on the paradoxical complexity of contemporary security frameworks, and their substantial human and institutional implications, will be disseminated through conferences, journals, media, and a policy brief that will inform accountable regional and international migration policy.

Keywords: deportation police bureaucracy state and governance infrastructure surveillance security india migrant illegality