Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A cost efficient, transparent and affordable digital procurement marketplace that allows MedTech industry and Hospitals to accelerate everyday processes (hystrix)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Across Europe and the globe, there is unprecedented financial pressure on healthcare players and providers, which, in turn, makes the European MedTech landscape increasingly challenging. As public procurement becomes more sophisticated, price transparency is growing, and demand for integrated solutions is driving changes in product offers, requiring new sales channels and tactics. The procurement of medical products, equipment and technologies in the health system is complicated by suboptimal, duplicated or repetitive processes which increase costs and delays for all stakeholders. hystrix medical AG was founded in August 2017 and their mission is to drastically accelerate everyday processes in the healthcare sector and to realise substantial efficiencies for healthcare providers and MedTech suppliers alike, so that they can focus on what really matters, patient outcome. The hystrix medical marketplace is the first digital marketplace for medical products in Switzerland and Europe that extends beyond pure tendering support to provide Healthcare providers (HCPs) and MedTech suppliers with an accelerated procurement experience, access to transact at market prices, smart contracting between counterparties, automated approval processing, and the opportunity to significantly redeploy FTE time and cost to more value additive tasks. The hystrix marketplace provides top performance while reducing the procurement process from months to minutes and reducing costs by 40 to 50% on commodity product procurement. The estimated savings in the Swiss hospital sector alone from the introduction the hystrix marketplace is €324m (CHF365M i.e. CHF1.3 M per hospital on average across the 283 hospitals). The time and relative cost savings estimated for Switzerland are foreseen within the EU market regardless of the relative price adjustment. The total expenditure on commodity MedTech products in Europe’s key markets (UK, Germany, France, Spain, Italy, etc.) was estimated to be €52bn

Keywords: procurement,healthcare,tendering,contracts,time to market,digital marketplace,medtech suppliers,algorithms,shopping cart optimisation,smart contracting
Wonderlogix STUDIO: Towards Seamless Industrial Control (Wonderlogix STUDIO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Israel
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Automatic Industrial Control Systems rely on obsolete PLC code, causing downtime and revenue losses. At the root lies the gap between design and programming that are performed by specialists with divergent knowledge. WONDERLOGIX STUDIO completely disrupts the balance of power between engineering companies and control system integrators, impacting the design and implementation of control systems. We bring the most cost-effective, robust and developer-friendly tool going beyond traditional IDEs to program PLCs with top-quality code. We shift PLC programming from using primitive language to an extremely high-level language, making it possible to program PLCs without writing a single line of code. Instead, sentences in human language are used to define the logic of operation and are automatically converted to top-quality PLC code. A universal, hardware-independent solution, WONDERLOGIX STUDIO will impact globally the industrial production cycles and performances, fostering revenue increase for European and global markets. Huge benefits of WONDERLOGIX STUDIO are: reduced commissioning time, optimal production, elimination of systems’ downtimes due to SW, minimization of damages and risk to facilities. Highly experienced both technically and commercially, we have a main objective: to bring our solution (in which we have already invested 400k€) to full maturity by integrating functionalities we identified during pilot testing in industrial environments and during demonstrations for prospective clients. Commercially, we tackle a huge market of PLC manufacturers (mostly EU, USA and Asia) and production industries. The Phase I feasibility assessment will include studies to assess technical barriers, evaluate risks, resources and strategies for technological developments and elaboration of a complete business and commercialization plan and deep assessment of the commercial risks associated with expanding our geographical markets, together with a Freedom to Operate Analysis.

Keywords: automated,control,systems,programming,facilities,industry,definitions,code,quality
Mediating the Future: The Social Dynamics of Public Projections (PROFECI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Israel
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2025-01-31
Duration (months): 72.0
Total project cost (EUR): 1499732.0
EU funding (EUR): 1499732.0
Participants: 1
Project status: SIGNED

People’s lives, both as individuals and at the collective level, are guided by projections about the future. This project aims to understand the complex processes through which projections about political issues, such as the outcomes and implications of elections, referenda, crises or wars, are formulated and negotiated within and through the media. It develops a new interdisciplinary approach and research tools for studying how projections evolve over time and through the contribution of various social actors (such as politicians, experts and journalists), and how they are received and acted upon by the public. The focus is on at least three retrospective case studies (projections about the Brexit referendum; the civil war in Syria; and Donald Trump's presidential bid) as well as three real-time case studies (to be selected based on geopolitical developments), characterised by high-visibility and involving projections with far-reaching implications. PROFECI integrates cutting-edge qualitative, quantitative and automated approaches to capture the interactive process underlying the construction and evolution of public projections, and their reciprocal relationship with people’s expectations and behaviour. It begins with an in-depth investigation of the construction, transformation and reception of projections made by key actors, using textual analysis of the source projections and their journalistic coverage, reconstruction interviews with experts and journalists, and focus groups with public members. The results of this stage inform the development of tools for a large-scale diachronic automated text analysis and panel surveys, which will be applied to the real-time and the retrospective case studies. By elucidating the life cycle of projections in a mediated environment, PROFECI opens up new avenues for understanding and researching adaptive social processes, such as self-fulfilling and self-defeating prophecies, and the role of the media in shaping the future.

Keywords: predictions,journalism,news,political communication,political judgment,expectations,public perceptions,social construction,social dynamics,automated text analysis,mixed methods
Control of Energy by Advanced Artificial Materials (CREAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 3
Project status: TERMINATED

The objective of the present project is to control the energy carried out by mechanical and electromagnetic waves by means of a new type of advanced artificial structures. To achieve this control resonant cavities for the simultaneous localization of elastic and electromagnetic waves will bedeveloped. The mentioned structures will be based on artificial anisotropic and inhomogeneous materials, designed by properly engineered periodic arrangements of scattering units. The project aims to exploit the unusual properties of these complex structures for the localization of the energy carried out by mechanical and electromagnetic waves, offering in this way a new insight to the field of artificial materials (metamaterials), where less attention has been given to the problem of localization of waves, since it has focused efforts in the extraordinary propagation characteristics of waves along them (negative refraction, cloaking, transformation acoustics and electromagnetics, etc.). The objectives of the project will be accomplished by the deep understanding of a new type of structures: Radial Wave Crystals (RWC), a special type of sonic and photonic crystals which present cylindrical or spherical symmetries. It is well known that cylindrical shells of RWC present extraordinary resonant properties. However, their study has been slow given the difficulties found in their physical realization. In this proposal this feasibility will be explored, and also less restrictive versions of RWC will be seek, but trying to keep their extraordinary properties. Finally, based on RWC a new type of optomechanical cavities will be investigated, by studying the electromagnetic and mechanical properties of these structures embedded in finite substrates. An iterative discussion with experimentalists at the IEMN (the host institution) will lead to a realistic proposal for the fabrication of an efficient optomechanical cavity based on inhomogeneous and anisotropic structures.

Keywords: periodic media,elastic waves,electromagnetic waves,phononic and photonic crystals,optomechanics,homogenization
Single molecule observation and manipulation of gene expression dynamics to dissect mechanisms of cell cycle entry (RNAREG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2021-08-31
Duration (months): 65.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Gene expression is a highly dynamic and inherently variable process. Yet, it needs to be tightly regulated, especially during the cell cycle, when continuous large-scale changes occur to the proteome. Even small deviations in the expression levels of a single protein in individual cells can de-regulate cell cycle entry and promote tumorigenesis. Here, I will develop new technology to study gene expression dynamics in single cells to uncover how active regulation and stochastic variability shape the expression of key cell cycle genes and ensure reliable cell cycle-entry decisions. I recently developed a protein multimerization system, called SunTag, which allows very bright fluorescence imaging, as well as manipulation of transcription. To understand how accurate expression levels of a core set of cell cycle proteins are achieved, I will combine single-cell RNA sequencing with SunTag fluorescence imaging technology to visualize, with single molecule sensitivity, the rates of transcription, translation and mRNA degradation. These analyses will identify the contribution of each type of regulation to accurate gene expression, and will reveal how active regulation ensures correct cell cycle decisions in the presence of stochastic expression variability. Furthermore, I will develop new methodology to specifically perturb the different types of gene expression control during defined cell cycle stages. This will enable an unprecedented ability to interrogate the function of gene expression control for cell cycle entry, and will identify the genes for which tight control of expression is critical for correct cell cycle decisions. Together, this approach will: 1) Uncover how individual regulatory mechanisms (e.g. regulation of transcription, translation or mRNA degradation) contribute to accurate cell cycle entry through gene expression control of key cell cycle proteins 2) Examine how stochastic variability in gene expression influences the decision to enter the cell cycle
A Collective Research Impact Framework and multi-variate models to foster the true engagement of actors and stakeholders in Health Research and Innovation (MULTI-ACT)

Framework: Horizon 2020 — Science with and for Society
Programme: Develop the governance for the advancement of responsible research and innovation by all stakeholders, which is sensitive to society needs and demands and promote an ethics framework for research and innovation
Action type: Coordination and support actions
Countries involved: Spain,Italy,Italy,Italy,Italy,Belgium,Finland,Poland,France,Portugal,Luxembourg
Call: New constellations of Changing Institutions and Actors (H2020-SwafS-2017-1, 2017)
Start date: 2018-05-01
End date: 2021-04-30
Duration (months): 36.0
Total project cost (EUR): 3430500.0
EU funding (EUR): 3430500.0
Participants: 13
Project status: CLOSED

Conventional accountability metrics to measure the impact of health R&I process normally are not able to represent the claims of different actors. The development of a new integrated collective research impact framework will be instrumental in enabling Return Of Investment (ROI) by each involved stakeholder in a view of collective sustainability. Economic and financial dimension (efficiency) has to be integrated with measures of mission success (efficacy), while being accountable to all the stakeholders who are directly or indirectly affected by an organization activity. Starting from the Integrated Accountability Model (IAM) in its different dimensions (mission, economic and social), new and appropriate metrics to evaluate impact of health research will be developed in a multistakeholder participatory approach. The IAM model will be expanded and fine-tuned in a new Collective Research Impact Framework (CRIF) to be applied to Multi-Stakeholder Research Initiatives in the domain of BRAIN diseases. The CRIF will be based on key requirements that will be jointly developed by different actors (i.e. research organizations, industry, civil society organizations, patients organizations, policy makers, governmental institutions): 1)the science of patient input; 2)common classification system to uniformly identify types of health R&I; 3)new metrics to measure the impact of R&I on patients and society; 4)strategic research global agenda and funding models; 5)committed partnership among health R&I stakeholders to create and oversee cooperative ventures; 6)mechanism to determine the nature of health R&I funding on a national level. MULTI-ACT proposal is led by patient organizations that act as mediators between science and patients/society. Addressed Responsible Research and Innovation issues are: Public engagement, Research governance and Research impact assessment as responsible research is the one that produces an impact on people and society.

Keywords: stakeholder engagement,innovative accountability framework,patients,public engagement
Context, Identity and Choice: Understanding the constraints on women's career decisions (CIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-07-01
End date: 2022-06-30
Duration (months): 60.0
Total project cost (EUR): 1998722.0
EU funding (EUR): 1998722.0
Participants: 1
Project status: CLOSED

There has been vast improvement in workplace gender equality, but there remain marked differences in the roles in which women and men work. Explanations for this inequality have focused on the barriers women face. However, as women begin to enter male-dominated roles, a new explanation has arisen: that remaining gender inequality must reflect fundamental differences between women and men, including differences in (a) ambition and desire for power, (b) needs for work-life balance, and (c) willingness to take career risks. Central to this analysis is the assumption that the glass ceiling is broken and thus inequality must be due to women’s active choices. This explanation downplays the fact that social context continues to be a barrier to women’s success and places responsibility for gender inequality on women themselves. Indeed, there has arisen the suggestion that gender equality necessitates women overcoming ‘internal obstacles’, ‘leaning-in’ and altering their choices (Sandberg, 2013), rather than challenging the status quo. I argue that diametrically contrasting structural barriers with women’s choices is unhelpful. Instead, I suggest that women’s choices are shaped and constrained by the gendered nature of organisational and social contexts and how women see themselves within these contexts. I propose a programme of research, across 3 integrated streams, that investigates how social and organisational structures define identities and constrain women’s choices in relation to ambition, work-life balance, and career risk-taking. I have four key objectives: (1) to clarify how organisational and social contexts define identity and constrain women’s choices, (2) to use an interdisciplinary, multi-methodological approach, to produce innovative theory and data, (3) to work collaboratively with stakeholders, and (4) to inform practical interventions designed to facilitate the increase of women’s participation in hitherto male-dominated roles.

Keywords: social identity,gender equality
Bio- & Photo-Catalytic Methods for the Construction of Enantiomerically Pure C-S Bonds in Thiols and Sulphides (BioPhoCS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2021-01-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.75999999998
Participants: 2
Project status: SIGNED

Organic sulphur compounds containing C-S chiral centres represent one of the most intriguing classes of chemicals due to their peculiar properties conferred by the unique chemistry of sulphur. Chiral sulphur compounds are known for their olfactory properties as flavours and fragrances and are ubiquitous in natural products and pharmaceutical ingredients such as penicillins and verticillins. Both the flavouring and pharmaceutical properties of chiral sulphur compounds are often determined by their absolute configurations. Therefore, the development of novel, robust and sustainable methods for the enantioselective construction of C-S bonds is of great importance in chemistry. In view of the lack of efficient and stereoselective methods in assembling asymmetrical C-S bonds, within this project we aim to construct enantiopure sulphur compounds through photo- and bio-catalysis. Various strategies have been designed to achieve this target, exploiting blue/green light photocatalysis and biocatalysis by reductase enzymes such as KRED, ADH and ERED. The ability of these enzymes to biocatalyse the enantioselective reduction of thioketones and thioalkenes obtained via photocatalysis, will be investigated. In addition, the combination of photocatalytic synthesis of substrates with the biocatalytic construction of enantiomerically pure C-S bonds in one-pot cascade processes will be developed. These methods will be finally applied to the synthesis of chiral volatile sulphur compounds as odorous excipients, while in-situ NMR kinetic studies of the photo-biocatalytic reactions will be carried out to get a better understanding of the reaction mechanisms. The successful development of these strategies will allow chemists and industries to access facile and sustainable approaches to prepare a wide range of challenging chiral thiols and sulphides to be used in the manufacturing of pharmaceutical ingredients, fine chemical tools (ligands, catalysts), agrochemicals and fragrances.

Keywords: biocatalysis,reductase,photocatalysis,sulphides,thiols,cascades,enantioselective reduction