Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Tissue-engineered oral mucosa cells for treatment of urethral strictures (TETUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-08-01
End date: 2021-07-31
Duration (months): 36.0
Total project cost (EUR): 2630270.0
EU funding (EUR): 1841189.0
Participants: 1
Project status: CLOSED

TETUS will address commercialisation complexities related to cell products and prepares MukoCell® for accelerated commercialisation by facilitating an EU-wide Market Authorisation. As MukoCell® addresses an unmet medical need, it is eligible to use an EU-accelerated market access pathway. Once Marketing Authorisation is in place, country-specific reimbursement strategies and market access (financial) plans can be developed that are requirments of for MukoCell® ready to go to market.Therefore, after TETUS, a radical increase in the sale of MukoCell® in the EU is expected in 2021 generating a revenue of €4.630 million followed by €13.890 million and €23.150 million from the market in the EU in 2022 and 2023, respectively. The clinical data produced through TETUS can be used to obtain Market Authorisation in other territories such as US and Asia.

Keywords: advanced therapeutic medicinal product,cell therapy,tissue engineering,urethral strictures
Tropical rain forest diversification: a GLOBAL approach (GLOBAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-10-01
End date: 2026-03-31
Duration (months): 66.0
Total project cost (EUR): 1951307.0
EU funding (EUR): 1951307.0
Participants: 1
Project status: SIGNED

Tropical rain forests (TRF) are the most species rich yet highly threatened ecosystems on Earth. They play pivotal roles as global climate regulators and for human wellbeing. Their long term conservation is central for global climate mitigation and biodiversity conservation. Elucidating the evolutionary processes that underpin this immense diversity is critical for improved conservation actions. What evolutionary processes determine TRF diversity? How will human-induced species losses impact the evolutionary history of TRF? Time calibrated phylogenies retain the fingerprint of these patterns and are fundamental prerequisites to maximize the conservation of evolutionary history. However, global densely sampled robust phylogenies are lacking for TRF plants, significantly limiting our ability to properly address these questions. I will generate the largest most comprehensive datasets ever assembled for a major, ecologically important and species-rich pantropical model plant family: Annonaceae (~2500 species). First, I will test major hypotheses about TRF evolution at a global scale and what biotic and abiotic factors drove their diversification. Then, I will predict the impact of plant species extinction on the evolutionary history of TRF. Using the extensive network of European herbaria, I will reconstruct a robust time-calibrated complete species level phylogenomic tree of Annonaceae. I will compile massive morphological, chemical and geographical datasets for all species. Novel paleoclimatic data will be modelled through space at ten discrete periods over the last 100 million years. These data will then be integrated using innovative statistical macroevolutionary comparative approaches to answer the above questions at never achieved levels of precision. GLOBAL will provide improved predictions of TRF evolution informing conservation policies, and set the new standard for next generation evolutionary studies of TRF evolution applicable to other key tropical groups.

Keywords: annonaceae,herbarium,next generation sequencing,tropical rain forest
Solar Energy Enabled for the World by High-resolution Imaging (SEEWHI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Denmark
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-05-01
End date: 2021-10-31
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

THE GOAL We will derive new and fundamental insight in the relation between nano-scale structure and the performance of 3rd generation solar cells, and determine how to apply this in large-scale processing. THE CHALLENGES We currently have a superficial understanding of the correlations between structure and performance of photovoltaic heterojunctions, based on studies of small-scale devices and model systems with characterization techniques that indirectly probe their internal structure. The real structures of optimized devices have never been “seen”, and in devices manufactured by large-scale processing, almost nothing is known about the formation of structures and interfaces. THE SCIENCE We will take a ground-breaking new approach by combining imaging techniques where state of the art is moving in time spans on the order of months, with ultrafast scattering experiments and modelling. The techniques include high resolution X-ray phase contrast and X-ray dark-field tomography, in situ small and wide angle X-ray scattering, resonant scattering and imaging and time resolved studies of charge transport and transfer. To relate our findings to device performance, we will establish full 3D models of charge generation and transport in nano-structured solar cells. THE FOCUS Solution cast solar cells is the only technology that promises fast and cheap industrial scaling, and it is consequently the focus of our efforts. They require a tight control of processing conditions to ensure that the proper nano-structure is formed in the photoactive layers, with optimal contacts to charge transport layers and interfaces. The prime contenders are non-toxic polymer and kesterite solar cells. THE IMPACT Our results may advance 3rd generation, solution-cast solar cells to meet the “unification challenge” where high efficiency, stability and cheap processing combines in a single technology, scalable to the level of gigawatts per day, thus becoming a centrepiece in global energy supply.

Keywords: solution cast solar cells,ultrahigh resolution imaging,ultrafast imaging of charge currents,modelling of charge generation and transport
Margination of Microcapsules in Small Arteries (MSMART)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-03
End date: 2017-09-02
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Intravascular delivery of microcapsules is emerging as a novel and effective approach in targeted therapeutic and diagnostic procedures in cancer and cardiovascular diseases. It encapsulates drugs or imaging-contrast agents and functionalizes the surface of the capsule to target specific diseased sites. However, a major challenge in its applications is to improve the adhesion efficiency of capsules to the endothelium (a monolayer of cells that lines the luminal surface of blood vessels) under complex blood flow conditions. While extensive research has focused on identifying disease-associated biomolecules on the endothelium, or suitable antibody/peptides targeting these molecules, much less attention has been given to the margination of the drug carriers from the blood stream to the vascular wall, especially in arteries where many diseases develop. Margination represents the crucial first step before adhesion. The aim of this project is therefore to investigate the cross-sectional migration of microcapsules in arterial blood flows and to develop scientific understanding of how the size, shape and deformability of capsules, as well as system parameters such as the blood haematocrit, blood flow inertia and pulsatility, and vessel geometry affect the margination of the microcapsules. The project will unit the state-of-the-art in-vitro, ex-vivo experimentation and numerical modeling resolving blood flow at a cellular level. A second aim of the project is to develop practical principles for designing microcapsules with optimum margination property in arteries. The project will pave the way for novel designs of injectable medicines or imaging-contrast agents with enhanced vascular targeting efficiency.

Keywords: margination,microcapsules,arterial blood flows,drug delivery
REliable Advanced Diagnostics and Control Tools for increased lifetime of solid oxide cell Technology (REACTT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Italy,Austria,Italy,Italy,Switzerland,Switzerland,Finland,Slovenia,France
Call: Diagnostics and Control of SOE (H2020-JTI-FCH-2020-1, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 2712322.5
EU funding (EUR): 2712322.5
Participants: 10
Project status: SIGNED

Solid Oxide Electrolysis (SOE) and its possibility to operate in reversible mode (rSOC) can play a major role in H2 production at low cost and for renewable energies storage. These operating modes with high current and transients can induce degradation that needs to be mitigated for successful system deployment. Federating the cumulated advances built up in preceding collaborative projects, REACTT, with an established expert team, will realize a Monitoring, Diagnostic, Prognostic and Control Tool (MDPC) for SOE and rSOC stacks and systems. Its hardware platform will embed diagnostics and prognostics algorithms, and interact with the system power converters without modification. It contains (a) an innovative excitation module to probe the stack with PRBS (pseudo-random binary signal) or sine stimuli, and (b) a control coordination unit, interfaced with real-time optimisation (RTO). The latter uses on-line measurements with a constraint-adaptive algorithm that drives the system to optimal operation, respecting all safety boundaries. Together, this approach will achieve to supervise and analyse the (reversible) electrolyser system, increase its reliability and extend its stack lifetime. REACTT will demonstrate the effectiveness of this approach by tests on a SOLIDpower (SP) 5 kWe SOE system and on an rSOC x kWe CEA system, both at TRL6. This validation in two different operating modes with two different stack designs will prove the generic character of the developed tools, which can then be extended towards multiple technologies and higher power applications. It will reduce the operation and maintenance costs by 10%; the additional cost of the MDPC tool will not exceed 3% of the overall system manufacturing costs. These ambitious targets will be pursued in close collaboration between 6 R&D (IJS, UNISA, CEA, VTT, EPFL, ENEA and HES-SO) and 3 industry partners (SP, Bitron and AVL) on the whole value chain from tests to systems through hardware and software developments.

Keywords: solid oxide electrolysis,monitoring,diagnostics,prognostics,control
Methodology Development and Validation of WEight Optimized Stiffeners Run-Out Design for Future Composite Wings (DOVER)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain
Call: Development of innovative and optimized stiffeners run-out for overall panel weight saving of composite wing (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2021-07-31
Duration (months): 41.0
Total project cost (EUR): 742430.26
EU funding (EUR): 742430.0
Participants: 3
Project status: CLOSED

DOVER aims to develop a design optimization tool and methodology dedicated to support the design of innovative and weight-optimized composite panel configurations with capability to improve all areas and configuration parameters such as geometries, stacking sequences or anti-peeling fasteners. The resulting methodology accuracy and reliability is to be validated by means of experimental tests. The project will be carried out in a 41-month time span. DOVER solution proposal is to create and validate a design tool and methodology that enables optimization of wing structural composite panels. The developed tool will provide an environment for the investigation of innovative lightweight shapes including stiffener geometry, thicknesses and lay-ups of different components, shape of the tapering or anti-peeling fasteners configuration. By means of this tool, the designer will be able to predict the failure of any stiffener run-out configuration and obtain a global panel optimization with considerable time savings, because it will not require any complex numerical models to predict behaviour, and economical, because it will not be necessary to carry out expensive testing campaigns. To achieve this solution, DOVER is structured in different stages that ensure maximum quality, accuracy and reliability. An initial experimental study of stiffener run-out behaviour will establish an experimental base that will be used to develop a model and to generate failure criteria prediction methodology. This methodology will be put in practice by designing different configurations of innovative stiffener run-outs. Optimized solutions will be evaluated and correlated against experimental results. For that, at a final stage, mono and multi stiffener panels will be manufactured, and stress and strain, damage tolerance and fatigue life will be obtained through experimental testing to validate the development.

Keywords: stiffener,run out,validation,wing,composite,optimization,design,structure
establishing Community Renewable Energy Webs - Rolling out a business model and operational tool creating webs of households that jointly manage energy to improve efficiency and renewables uptake (eCREW)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Italy,Spain,Germany,Germany,Spain,Austria,Greece,Türkiye,Türkiye
Call: The role of consumers in changing the market through informed decision and collective actions (H2020-LC-SC3-EE-2019, 2019)
Start date: 2020-06-01
End date: 2023-06-30
Duration (months): 37.0
Total project cost (EUR): 1996112.5
EU funding (EUR): 1996112.5
Participants: 10
Project status: SIGNED

eCREW coordinates and supports the roll-out of an innovative scheme of household cooperation in energy management. These are Community Renewable Energy Webs (CREWs), in which households jointly exploit household-level electricity generation and battery storage capacities and optimise energy efficiency and expenditures. The key purpose of CREWs is to support the transition of passive consumers to active participants in the local energy system through informed decisions and collective actions. In eCREW, three energy companies from DE, TR and ES (Lighthouse Communities) will roll-out the eCREW approach to their clients. A strong and divers Follower Community made up of entities from AT, DE, ES, FR, GR, SE and TR is made fit for giving the eCREW approach a “Go”, too. Together, 240,000 households will be enabled to join a CREW during the project runtime, establishing about 200 CREWs with 15,000 participants, saving at least 13 GWh/year. Cooperation within a CREW is facilitated through the provision of an award-winning smart phone app (PEAKapp), exploiting smart meter data to stimulate an increase in energy efficiency and the uptake of local renewable electricity generation. Administration of the CREWs, including the billing of consumption and generation, is covered by electricity retailing companies which are thereby transformed into holistic service providers; we call them Community Administering Entities (CAEs). In our approach, administrative burdens are relieved from the households, who are then free to focus their efforts on making the most out of their participation in a CREW. Monetary benefits from the eCREW approach are distributed amongst prosumers, traditional consumers, and the CAE through an innovative split-incentives contract applied in the project. The financial arrangement is tailored to ensure that the eCREW approach is financially viable and attractive for all participants and allows a non-discriminatory participation of all households.

Keywords: energy community,citizens energy community,renewable energy community,collective actions,smart meter,loadshifting,energy savings
Low Cost Interconnects with highly improved Contact Strength for SOC Applications (LOWCOST-IC)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Austria,Germany,Germany,Italy,Italy,Sweden,Belgium,Sweden,France,Denmark
Call: Cost-effective novel architectures of interconnects (H2020-JTI-FCH-2018-1, 2018)
Start date: 2019-01-01
End date: 2022-09-30
Duration (months): 45.0
Total project cost (EUR): 2335997.5
EU funding (EUR): 2335997.5
Participants: 10
Project status: CLOSED

Lower costs and a better long-term stability are needed to accelerate commercialization of Solid Oxide Cell (SOC) technology. Among the enduring challenges is degradation related to the steel interconnect (IC) material and insufficient robustness of the contact between the IC and the cell. LOWCOST-IC will tackle these issues by developing, fabricating and demonstrating low-cost ICs and exceptionally tough contact layers for use in SOC stacks. Novel robust contact layers, utilizing the concept of reactive oxidative bonding, will substantially improve the mechanical contact between the cell and the interconnect, while ensuring a low and stable area specific resistance. The cost of SOC ICs will be reduced by combining cost-effective high volume steel grades with highly protective coatings. Large-scale mass manufacturing methods will be demonstrated for application of the coating by physical vapour deposition (PVD), for subsequent shaping of the ICs by hydroforming and finally for fast printing of contact layers by a drop-on-demand process. Novel computationally efficient stack models will together with hydroforming be customized to decrease the prototyping costs and thereby accelerate IC development. The new interconnect steels, coatings and contact layers will be implemented in the SOC stacks of two commercial manufacturers and undergo extensive testing in an industrially relevant environment. Finally, the cost-effectiveness of the proposed production route will be assessed and compared with existing production routes to facilitate a fast market entry of the project innovations. The overall effort will bring the technological solutions from their current TRL 3 to TRL 5. To achieve the optimum output, the LOWCOST-IC consortium comprises the entire interconnect and contact layer supply chain.

Keywords: protective coatings,high robustness,low cost steels,physical vapor deposition,reactive oxidative bonding
O.M.P.M LiferCraft Fabrication Innovative Tool Tail (OLFITT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Italy
Call: Prototype Manufacturing Tooling for Single Parts Manufacturing of the Rotorless tail for LifeRCraft. (H2020-CS2-CFP02-2015-01, 2015)
Start date: 2016-09-01
End date: 2020-03-31
Duration (months): 43.0
Total project cost (EUR): 1071400.0
EU funding (EUR): 749980.0
Participants: 2
Project status: CLOSED

The aim of this proposal is to develop, design, manufacture and deliver to the Core Partner of the Call For Core Partner AIR-02-02, the prototype manufacturing tooling to fabricate all composite parts of the LifeRCraft Rotorless Tail that belong to the WP_B4.1 Rotorless Tail for LifeRCraft i.e.: Tail Boom, Horizontal Stabilizer, Vertical stabilizer, Control Surfaces, Upper Tail Boom Fairing. According to the call, composite parts could be fabricated using a variety of materials and process to be defined before activities start. In terms of cost, schedule reduced fabrication flow, reduced environmental impact the proposal outlines different tooling approach in relation with the different process outlined in the call. These include prepreg and out of autoclave technology for which, taking in account preliminary shape and dimension of part, main tooling issues like materials, configuration, thermal behaviour etc. are evaluated on the basis of proponent know how. In particular the use of RUPS (Recovered Uncured Prepreg Scraps) developed by proponent is suggested as a valid opportunity to reduce materials cost still holding advantages of composite tools in terms of reduced flow and energy consumption. Manufacturing tool approach will be selected in close agreement with core partner responsible of composite tail fabrication having in mind the need of a light tool chain as suitable for prototypic fabrication. In WP1 the fabrication tool complete with additional tools as trimming template, will be designed and fabricated. After dimensional and functional check the fabrication tools will be delivered to the Core Partner responsible for tail fabrication. The WP2 will be devoted to assessment of delivered tools to report configuration trades. In WP3 the proponent will support the Core Partner in tool try out and use of tools for part fabrication. WP4 will handle all the management, communication and dissemination activities.

Keywords: composite,fabrication,recovered scraped uncured composite prepreg