Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Role of selective autophagy processes in regulating the glucose tolerance of carnivorous fish: seeking greater replacement of fishmeal by vegetal ingredients in aquafeeds (MEAL fish)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: SIGNED

The overarching goal of MEAL fish is to further understand the role of chaperone-Mediated autophagy (CMA) and Endosomal microautophagy (eMI) in AquacuLture fish, and to determine their relative contribution to nutrient utilization and metabolism. Deciphering the role of CMA and eMI in the control of carbohydrate metabolism will contribute to shed light on diverse physiological processes that can ultimately affect fish production, including nutrition and growth. During this trainee-development focused project, the fellow, through his interactions with the supervisor and the partners (H. Wodrich, and A. Herpin, from the stellar French research institutions CNRS and INRAE, respectively), will acquire diverse state-of-the-art skills that significantly enhance his scientific and technical knowledge. The mentor (I. Seiliez, UMR1419 INRAE NuMeA) is an internationally recognized leader in autophagy, fish metabolism and genomics and provides an excellent training environment for the applicant, an experienced researcher (ER) and emerging young leader in fish biology research. It is noteworthy the novelty and originality of the project, which proposes to gain insights on the function of a recently discovered process in fish, CMA, together with the barely known eMI, and to study its applied scope in aquaculture for the promotion of the use of non-fishmeal nutrients in aquafeeds. The project focuses on an important commercial species of the European aquaculture, the rainbow trout (O. mykiss). The European research competitiveness will be continuously enhanced throughout the project by the superior training of the ER, the interaction between multidisciplinary researchers, and translating for commercial use of the derived new knowledge on the regulation of CMA and eMI and its contribution to fish production. This project will ultimately contribute to the EU food sustainability, economy, employment and maintenance of its status as a group of high-level-knowledge countries.

Keywords: autophagy,rainbow trout,glucose,chaperone mediated autophagy,endosomal microautophagy,intermediary metabolism,fish
A SOLAR URBAN HUB with integrated lighting and information system for optimal Smart Cities efficiency (THE SOLAR URBAN HUB)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2019-01-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Commitment to clean energy nowadays should be essential for governments, companies and citizens. Sustainable urban planning helps improve the welfare of the community, shaping public areas into clean and efficient spaces to live. On the other hand, IoT is changing the way in which cities are operating by enabling effective infrastructure management. The Solar Hub is a new concept of solar urban furniture which converts smart street lighting into an IoT enabling smart city tool. Conventional street lighting is associated with high energy and maintenance requirements, resulting in high costs for municipalities. Although energy efficient lighting solutions are gaining ground, they often fall short of addressing the sustainable development of Smart Cities: lack of aesthetic appeal, no-use of solar energy, difficult integration of sensors and smart devices and not designed for a long term retrofitting. SIARQ addresses all these challenges in a single solution, championing a new concept of solar urban furniture. The Solar Hub belongs to the new generation of Cradle to Cradle zero CO2 emissions products entirely powered by the Sun. It stands out by its dome-shaped lightweight photovoltaic module that houses environmental sensors and other smart devices that enable different kinds of monitoring. SIARQ thus actively contributes to overcoming the lack of interoperable solutions and the risk of fragmentation that have been acknowledged by the European Commission as major challenges to the deployment and exploitation of the IoT potential. SIARQ’s business model targets Telecoms, IT service providers and Energy Service Companies as preferential channels to reach the end users and to generate new business models with shared incomes. The phase 1 feasibility study will focus on validating the business model and commercialization strategy, planning of all activities for an in-field pilot in a city environment and elaborating industrialization and marketing plans.

Keywords: architecture,urban landscape,solarization,photovoltaics,energy autonomy,new urban infrastructure
Scalable Control of Interconnected Systems (ScalableControl)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Sweden
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2024-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Modern society is critically dependent on large-scale networks for services such as energy supply, transportation and communications. The design and control of such networks is becoming increasingly complex, due to their growing size, heterogeneity and autonomy. A systematic theory and methodology for control of large-scale interconnected systems is therefore needed. In an ambitious effort towards this goal, this project will develop rigorous tools for control synthesis, adaptation and verification. Many large-scale systems exhibit properties that have not yet been systematically exploited by the control community. One such property is positive (or monotone) system dynamics. This correspond to the property that all states of a network respond in the same direction when the demand or supply is perturbed in some node. Scalable methods for control of positive systems are starting to be developed, but several fundamental questions remain: How can existing results be extended to scalable synthesis of dynamic controllers? Can results for linear positive systems be extended to nonlinear monotone ones? How about systems with resonances? The second focus area, adaptation, takes advantage of recent progress in machine learning, such as statistical concentration bounds and approximate dynamic programming. Adaptation is of fundamental importance for scalability, since high-fidelity models are very expensive to generate manually and hard to maintain. Thirdly, since systematic procedures for control synthesis generally rely on simplified models and idealized assumptions, we will also develop scalable methods to bound the effect of imperfections, such as nonlinearities, time-variations and parameter uncertainty that are not taken into account in the original design. The research will be carried out in interaction with industry studying a new concept for district heating networks. This collaboration will give access to experimental data from a full scale demonstration plant.

Keywords: systems theory,network dynamics,formal methods
Endosomal control of local protein synthesis in axons (AXONENDO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Italy
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1499563.0
EU funding (EUR): 1499563.0
Participants: 1
Project status: SIGNED

Neurons are morphologically complex cells that rely on highly compartmentalized signaling to coordinate cellular functions. The endocytic pathway is a crucial trafficking route by which neurons integrate, spatially process and transfer information. Endosomal trafficking in axons and dendrites ensures that required molecules and signaling complexes are present where and when they are functionally needed thus fulfilling essential roles in neuronal physiology. Our recent work has revealed the presence of mRNAs and ribosomes on endosomes in axons, raising the exciting possibility that these motile organelles also directly modulate the local proteome by controlling de novo protein synthesis. However, the mechanisms by which endosomes regulate mRNA translation in neurons is unknown. Moreover, the roles of endosome-mediated control of protein synthesis in neuronal development and function have not been investigated. Here, we propose to bridge this knowledge gap by elucidating links between the endocytic pathway and local protein synthesis in neurons, focusing on their functional relationship in axons. By combining genome-wide analysis, genetic tools, state-of-the-art imaging techniques and the use of Xenopus and mouse vertebrate models, we plan to address the following fundamental questions: (i) What are the mRNAs associated with endosomes and does endosomal trafficking regulate their axonal localization? (ii) Does the endocytic pathway mediate the selective translation of axonal mRNAs in response to extracellular factors? (iii) What are the endosome-associated RNA-binding proteins, and what is the effect of perturbing these associations on axonal development and maintenance in vivo? (iv) Does impaired endosomal regulation of axonal mRNA localization and translation cause axonopathies? Answering these questions will set strong foundations for this new area of research and can provide a new angle in our comprehension of neuropathies in need of novel therapeutic strategies.

Keywords: axon,mrna trafficking,mrna translation,endosomes,axon development and maintenance,disease
Theranostic Injectable Hydrogel for Glioblastoma (HyGlio)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-09-30
End date: 2019-09-29
Duration (months): 36.0
Total project cost (EUR): 244269.0
EU funding (EUR): 244269.0
Participants: 2
Project status: CLOSED

Glioblastoma multiforme (GBM) is the most frequent brain tumor in adults and is characterized by invariably fatal prognosis. Although the incidence of GBM is less than 10 to 100,000, the median survival of approximate 1 year from diagnosis makes it a considerable socio-economic burden. The presence of biological barriers for effective drug transport to the brain, the strong migrating-ability of the tumor and its rapid evolution into more aggressive and treatment-resistant variants, make GBM extremely hard to treat with traditional systemic chemotherapy. The HyGlio project proposes an ambitious bottom-up approach to build a multifunctional tool for long-term imaging and treatment of GBM, combining multiple treatment strategies, patient-specificity, and BBB bypassing in an all-in-one system. The system combines the advantages of: (i) Intracranial treatment, which maximizes efficacy while minimizing side effects; (ii) mild gelling conditions of the hydrogel, which reduce potential damages to the healthy tissue; (iii) increased drug penetration and selectivity due to the use of targeted polymer nanoparticles; (iv) Inhibition of molecular mechanisms involved in GBM spreading and aggressiveness; (iv) theranostic potential, due to the presence of magnetic resonance imaging, agents for rapid therapy adjustment according to patient’s needs. The HyGlio project is expected to introduce innovative concepts and methodologies for the treatment of GBM, by providing advanced and promising tools for more efficient therapy and increased patient outcome.

Keywords: nanoparticles,polyurethanes,cancer treatment,hydrogels
Industrialisation of the CoeLux(VR) product line, through upscaling of the nanodispersion production process, and optimisation of the production chain (CoeLux VR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 3113376.25
EU funding (EUR): 2179363.0
Participants: 1
Project status: CLOSED

Changing the way we experience the light, bringing the outdoors indoors: this is the mission of the CoeLux technology, which after 12 years of research, managed to obtain CoeLux(HE), the first commercial product able to reproduce sky and sunlight in an interior space. The result is a warm, direct, sunlight and a surrounding sky light, completely transforming indoor spaces, giving them volume and shape through light and shadow, and which allows creating a new relationship between people and the surrounding architecture. The next step of the company’s growth plan is to bring this pioneering product, which can be produced for a small niche of high-end users, to the industrial scale, thus satisfying the blossoming demand. This will be the focus of the CoeLux(VR) innovation project, which will deliver two new modular systems (SkyBlade and SkyCasket), amenable to large scale production. This will be achieved through 4 developmental stages: 1 Upscaling of the nanomaterial dispersion used to coat the diffusing panel which represents the company’s key and proprietary technology. 2. Upgrade of the LED source and the optical design, which allows incorporating a radically new LED system, exclusively designed for CoeLux. 3 Engineering, industrial design and packaging, which focusses around the customers’ perception of the product, as well as its industrial manufacturing process. 4. Finally, the overarching ambition is to set-up the production supply chain, inspired by lean manufacturing principles, organizing the sourcing of the semi-finished products from the selected suppliers, and the internal production logistics in a standardized manufacturing plan, in view of the high-end positioning of the product. The project results will allow CoeLux to ramp-up its operational capacity, also increasing the company’s preparedness to the global market through core assets as product certification, trademark, and IP protection, thus reaping the benefit of this revolutionising technology.

Keywords: design driven,sustainability,human centric technology,high comfort illumination,daylight,start up,industrialization processes
REspiratory Science Promoted by International Research Exchanges 3 (RESPIRE 3)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Switzerland
Call: Marie Skłodowska-Curie Co-funding of regional, national and international programmes (COFUND-FP) (H2020-MSCA-COFUND-2015, 2015)
Start date: 2016-09-01
End date: 2022-02-28
Duration (months): 66.0
Total project cost (EUR): 2265600.0
EU funding (EUR): 1132800.0
Participants: 1
Project status: CLOSED

The European Respiratory Society (ERS) is the main scientific society in the respiratory field in Europe. ERS mission is to promote lung health and to drive globally standards for respiratory medicine. ERS aims at consistently achieving its core mission by supporting the forefront of basic and translational research. Since 1997, ERS has operated a successful programme of international exchange of researchers in respiratory science. Under the FP7 COFUND scheme, ERS launched RESPIRE 1 and RESPIRE 2 fellowship programmes. Here, ERS proposes RESPIRE 3, a new fellowship programme that capitalises on the success of the previous programmes and presents innovative features, taking into consideration the results of the independent evaluation of the RESPIRE 2 programme. First, RESPIRE 3 funds both European and global fellowships, expanding the international dimension to Third Countries. Second, RESPIRE 3 places major attention to inter-sectoral exposure: fellows have the possibility to undertake a secondment to industry, fully funded by the programme. Third, RESPIRE 3 complements the host institutions’ programme by proposing training activities aimed at strengthening the professional development of the fellows. Fourth, RESPIRE 3 sets the frame for the establishment of international contacts by offering dedicated networking opportunities, namely during the annual ERS congress. Fifth, with an increased living allowance and by introducing a family allowance, RESPIRE 3 provides competitive working conditions to attract the best talents and guarantee them a right balance between career ambitions and personal development. Therefore, the proposed RESPIRE 3 programme, by training post-doctoral fellows in Europe and globally, will enhance research in the respiratory field, increase the human resources potential in Europe, and contribute to the overall objective and impact of COFUND.

Keywords: lung disease,respiratory research,inter sectoral exposure,mentoring,european fellowship,global fellowship,career development
Mathematical Optimization for clinical DEcision Support and Training (MODEST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2020-06-30
Duration (months): 60.0
Total project cost (EUR): 1998500.0
EU funding (EUR): 1998500.0
Participants: 1
Project status: CLOSED

Physicians need to make many important decisions per day. One clinical example is the scheduling and dosage of chemotherapy treatments. A second example is the discrimination of atrial fibrillation from atypical atrial flutter, based on ECG data. Such important and complex decisions are usually based on expert knowledge, accumulated throughout the life of a physician and shaped by subjective (and sometimes unconscious) experience. It is not readily transferable and may be unavailable in rural areas. At the same time, the available imaging, laboratory, and basic clinical data is abundant and waits to be used. This data is not yet systematically integrated and often single data-points are used to make therapy decisions. More and more clinical decision making tasks will be modeled in terms of mathematical relations. I propose a systematic approach that supports and trains individual decision making. The developed ideas, mathematical models, and optimization algorithms will be generic and widely applicable in medicine and beyond, but also exploit specific structures, resulting in a patient- and circumstance-specific personalized medicine. This allows, e.g., a physician to first simulate the impact of his decisions on a computer and to consider optimized solutions. In the future, it will be the rare and unwanted exception that an important decision can not be backed up by consultation of a model-driven decision support system or based upon a systematic model-driven training. MODEST has a mathematical core. It builds on a comprehensive, interdisciplinary work program, based on disciplinary expertise in mixed-integer optimal control and existing collaborations with medical and educational experts. It is both timely, given the increasing availability of data and the maturity of mathematical methods, models, and software; as well as high-impact, due to the large number of clinical areas that may benefit from optimization-based decision support and training tools.

Keywords: decision support,decision training,transfer to clinical practice,cardiac arrhythmia,acute myeloid leukaemia,dynamic systems,mixed integer nonlinear optimization