Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Multiscale data-driven constitutive modelling and failure analysis of composite liquid hydrogen tanks (LH2COMP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 209483.28
EU funding (EUR): 209483.28
Participants: 3
Project status: SIGNED

Liquid hydrogen (LH2) is a promising propellant for aviation decarbonization. Developing safe, lightweight composite LH2 tanks is crucial to ensure long-range and safe transportation in future sustainable aircraft. LH2 tanks have the potential to replace traditional metal tanks, enabling high hydrogen storage densities per unit mass. However, due to the poor impact resistance and complex damage mechanisms of carbon fibre-reinforced polymer (CFRP) composites, safety is still a concern when the tank is subjected to transverse impact. Therefore, it is imperative to design impact-resistant LH2 tanks that meet safety requirements. Determining how to replace costly dynamic tests and accurately predict the thermomechanical responses of composite LH2 tanks under complex conditions is critical for developing and deploying new LH2 tanks. Therefore, this fellowship, with a planned secondment at TU Delft, aims to achieve the following: (1) Obtain the comprehensive mechanical properties of composites for LH2 tanks under complex loading conditions (uniaxial and biaxial), strain rates (0.1 to 5000 s⁻¹), and temperatures (−253 to 25°C). (2) Establish high-fidelity RVE-based FE models of CFRPs and develop a PINN-based constitutive model using small sample data, incorporating strain rate sensitivity, temperature effects, and biaxial loading coupling into the LaRC05 criterion to enhance its predictive capabilities under service conditions. (3) Create a systematic and fundamental understanding of the CAI strengths and failure mechanisms of CFRPs under much broader multiaxial loading conditions and various temperatures using a patented test rig; (4) Develop a multiscale virtual design and test tool for LH2 tanks to assess CAI strengths under various impacts (LVI to HVI), and train DNN models to predict biaxial CAI strengths; (5) Create a dedicated platform to disseminate the proposed failure criterion and promote virtual design and testing of LH2 tanks backed up by physical tests.

Keywords: composite materials liquid hydrogen tank multi scale analysis data driven constitutive modelling impact damage mechanism biaxial compression after impact
Entangled Christianities in Jerusalem and the Middle East: A cross-cultural bottom-up approach (12th-16th centuries) (ChrIs-cross)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Egypt,France
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1997676.0
EU funding (EUR): 1997676.0
Participants: 2
Project status: SIGNED

ChrIs-cross will produce the first comprehensive study of Christianities in Jerusalem and the Middle East from the 12th to the 16th c., in the face of shifting rulership structures, first Frankish, then Islamic, and religious affiliations. It will envisage them from a bottom-up, practice oriented and connected perspective, on the assumption that inter-Christian and Christian-Muslim relations were more conductive to fluidity than to boundary-setting. A multidisciplinary and multilingual team will study a forgotten and so far, inaccessible archive—the archives of the Christian Patriarchates in Jerusalem—and develop an overarching database including interactive maps and editing texts. Open-access metadata will be in English and Arabic. In so doing, it will resituate the history of Christianities within the Islamicate world by reassessing the concept of “minority”, historicise communities’ construction by comparing conquest-induced reconfigurations, with and without a change in religious dominance, and spatialise these processes by examining their interplay, with Jerusalem as a specific urban space in tension with the wider regional area. The project has three main objectives: it aims to address the currently compartmentalised academic study of the diverse Frankish- and Islamic-ruled societies, by shifting the focus of inquiry from the internal history of separate groups to their areas of contact; to empower local Christian communities by documenting their deep-rootedness in these complex societies, and to contribute new knowledge of the diversity of the Islamic-ruled world as a historical reality by expanding digital inclusiveness. By achieving its various objectives, ChrIs-cross will realize what arguably is an unprecedented exploration. It will thus have a major scholarly and social impact, both for the many Christian communities now facing extinction, and for people in the so-called West, which faces an inflation in essentialist discourses on religion.

Keywords: eastern christianity christian muslim relations islamicate world middle east jerusalem cross cultural studies social and urban history archival survey
Role of the kinase TAOK2 in the innate immune response to viral infection (TIRI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

Viral infections are a major threat to public health worldwide. The innate immune response acts as the first line of defense during viral infections by recognizing pathogen-associated molecular patterns such as double-stranded RNA (dsRNA). Impaired innate immune signaling sensitizes patients to viral infections, while aberrant innate immune activation is associated with autoimmune diseases. Recently, the host laboratory identified the protein kinase TAOK2 as a novel co-factor for viral dsRNA sensing. TAOK2 binds and is activated by dsRNA, and its depletion leads to an impaired immune response to viral infection. Notably, a mutation in TAOK2 causes immunodeficiency in human patients. These findings suggest a previously unappreciated role for TAOK2 in innate immunity, but the molecular details remain unclear. I will use synergistic biochemical, systems biology and in vivo approaches to comprehensively define the role of TAOK2 in innate immunity. First, I will use state-of-the-art biochemical and structural approaches to define the mechanism of dsRNA recognition by TAOK2 and discern the molecular basis for the disease-causing point mutation. Second, I will perform a multi-level systems biology analysis to integrate TAOK2 into a dynamic signaling network in response to viral infection. Third, I will assess the consequences of complete loss of TAOK2 and the clinically relevant TAOK2 point mutation in vivo using mouse models. This highly interdisciplinary and collaborative project will combine my existing expertise in biochemistry and in vivo approaches with the systems biology competencies of the host laboratory. Thereby, I will gain novel insight into the signaling network that governs the innate immune responses to viral dsRNA. The training during this project will increase my scientific and transferable skills, reintegrate me into the European research community, and thereby help me achieve professional maturity and academic independence.
Integrating Network Digital Twinning into Future AI-based 6G Systems (6G-TWIN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Luxembourg,Belgium,Italy,Germany,Portugal,France,Türkiye,Ireland
Call: System Architecture (HORIZON-JU-SNS-2023, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 4190678.75
EU funding (EUR): 3999647.5
Participants: 12
Project status: SIGNED

The overarching objective of 6G-TWIN is to provide the foundation for the design, implementation and validation of an AI-native reference architecture for 6G systems that incorporates Network Digital Twins (NDT) as a core mechanism for the end-to-end, real-time optimisation, management and control of highly dynamic and complex network scenarios. To achieve this objective, 6G-TWIN will deliver methods, modelling and simulation solutions for the definition, creation and management of multi-layered virtual representations of future 6G systems, where heterogeneous domains (i.e., edge, fog and cloud) and communication technologies (e.g., cellular, optical and Non-Terrestrial Networks (NTN)) coexist. The project solutions will be demonstrated in two complementary use cases addressing mobility and energy-efficiency challenges, aligned with the expected use cases of 6G and the Key Performance Indicators (KPI) defined in previously funded projects (including SNS JU STREAM-C/D-2022). Finally, the participation of Small and Medium-sized Enterprises (SMEs) will ensure that the 6G-TWIN consortium pays particular attention to the replication, reengineering and exploitation of the project outcomes, regularly aligning the requirements of standardisation bodies with predicted market needs.

Keywords: network digital twin,ai native architecture,federated simulation,network planning,management and control
Long live the oocyte: studying protein lifespan in oocyte health (ProteOOcyte)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

Oocytes form during embryonic development and persist in a dormant state for decades, representing some of the longest-lived cells in our body. As oocytes transfer their cytoplasm to the early embryo and the next generation, the regulation of its quality serves as a unique evolutionary strategy to preserve cellular longevity and fertility. Protein turnover is essential for replacing damaged molecules with their functional copies since long lifespans expose proteins to damage accumulation, including age-related post-translational modifications (PTMs). Recent data show that oocytes have low protein turnover rates, suggesting they retain many extremely long-lived proteins (ELLPs). How these ELLPs are stabilized and contribute to oocyte health remains unknown. With this innovative action, I aim to map ELLPs that emerge during oocyte formation and persist throughout its lifetime, characterize the molecular mechanisms by which they are regulated, and functionally assess their role in preserving oocyte quality. I will combine longitudinal labeling-based mass spectrometry with fluorescent imaging to characterize and quantify oocytes’ ELL proteomes and study their regulation by measuring PTMs. I will then combine an oocyte in vitro differentiation protocol with a genetic perturbation screen to investigate ELLP function by selectively and timely perturbing them, determining whether their long-live nature is essential for oocyte quality. Female infertility is one of the biggest societal challenges of our time. Over one in four fertility problems are unexplained, highlighting a significant knowledge gap in female reproduction. This project will provide new insights into the mechanisms by which mammalian oocytes regulate protein homeostasis. Its relevance transcends reproductive biology, filling a critical gap in our understanding of protein quality control mechanisms in non-dividing cells and providing new angles to interpret age-related deterioration and female infertility.

Keywords: oocyte,long lived proteins,protein homeostasis,cellular aging,fertility
Fashioning Power through South-South Interaction: Re-thinking Creativity, Authenticity, Cultural Mediation and Consumer Agency along China-Africa Fashion Value Chains (China Fashion Power)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1996206.0
EU funding (EUR): 1996206.0
Participants: 1
Project status: SIGNED

The project investigates how, in the context of the Belt and Road Initiative, China’s global power is manifested, negotiated and resisted in people’s daily life in a South-South setting using fashion as an exemplary case. Fashion is recognised as a significant economic force globally and one of the most poignant indicators of cross-cultural exchange. By critically examining China-Africa networks of fashion production, trade and consumption, this project will theorise how fashion is created, circulated, valuated, and consumed in and through Global Souths Value Chains (Guangdong-Nairobi-Maputo), dissecting complex dynamics and expressions of power. Using a multi-disciplinary, multi-method, multi-sited, and multi scalar approach, the following questions frame this project and its four subprojects: 1) How are everyday fashion products designed and produced in China for African markets; 2) How do Chinese and Africans interact to valuate and trade fashion products for Kenyan and Mozambican markets; 3) How and by whom are cultural differences negotiated and mediated in the marketplace; and 4) What values, meanings and “power” do African consumers derive from consumption, and what ideas and constraints are imposed on them? This project’s major contribution is threefold. Theoretically, it will move beyond a Western-centric epistemology to map the chains, restraints and materialities of China’s power expansion through fashion. Methodologically, this project will synergistically collect and triangulate empirical information along complete South-South commodity chains through multi-sited ethnography, semiotic and visual analysis, individual and focus group interviews, and wardrobe archival studies. Empirically, it will provide evidence of how Chinese-African fashion industries impact upon the social, cultural, economic and affective lives of African consumers in the context of increasing globalisation, digitalisation, consumerism, and China’s ambition abroad.

Keywords: africa,china,consumption,creativity,fashion,global south
Quantum Simulator with Hot Atomic Vapors (SQVAC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-05-01
End date: 2025-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

In the context of the ongoing development of novel quantum technologies, including quantum sensors, quantum communication, quantum simulators and quantum computing, some devices are mature without resorting to the powerful but fragile entanglement between qubits. Exploiting the wave nature of devices, photons often play an important role. In order to enlarge the potential of photonic devices, controlled atom-photon interactions will be pushed to new limits in order to build analog and digital wave simulators. In the present project, these interactions are mediated via photon-atom coupling using room temperature cells of atomic vapours.
Theoretical and computational study of polymers - fluorescent proteins mixtures for applications in bio-LEDs (BIOS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

In the field of lighting, a new technology has recently appeared: the bio-LED, which makes use of derivatives of the green Fluorescent Protein (FP) as downcoverting materials. This provides a cheap, green and easy to procure replacement for the currently used rare-earths-based downconverting filters, whose sustainability is hindered by the associated costs and their ecological impact. Despite the encouraging results obtained so far, the bio-LED needs improvements in terms of stability and performances in order to become competitive in the market. BIOS (BIO-led through Simulations) aims at addressing these issues by studying the fundamental structural and electronic properties of the FP-based filter at realistic, working conditions (i.e. high temperature) using a theoretical and computational approach. This will allow us to characterise the interactions that stabilise the FP-polymer matrix mixture, thus providing guidelines for the chemical design of components of the downconverting filters to improve thermal stability. Hybrid approaches that makes use of molecular dynamics, molecular mechanics, quantum mechanics and analytical models will be employed to first characterise the interactions that stabilise FPs in non-physiological conditions while allowing them to maintain their optical activity, and then to study in detail the deactivation paths of the FPs, with a particular focus on thermal dissipation procceses, which currently constitute the main obstacle to the market competitiveness of the bio-LED technology. Through BIOS we will therefore obtain insight in the strategies to adopt to improve the performances of the final device.

Keywords: biomaterials,biophysics
AI-driven discovery broad-spectrum antivirals targeting Nucleocytoviricota factories via phase separation modulation (PSDisrupt)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-10-01
End date: 2027-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The phylum Nucleocytoviricota includes (re-)emerging dsDNA viruses of major concern, such as monkeypox virus (mpox) and African swine fever virus (ASFV). Despite their economic and public health impact, no formally approved antivirals exist for these pathogens. Viral factories (membrane-less organelles essential for replication) are highly conserved across Nucleocytoviricota, presenting an attractive and untapped target for antiviral intervention. PSDisrupt builds on findings from the ERC-funded ViDaMa project, which identified scaffold proteins governing phase separation in viral factories. These proteins share a conserved "molecular grammar" essential for condensate formation. Disrupting this process is expected to broadly inhibit viral replication while minimizing the development of resistance. This PoC project will design phase-separation grammar-targeting antivirals using AI-driven pipelines. Deep learning models will enable the screening of ultra-large chemical spaces to identify: (i) broad-spectrum inhibitors targeting conserved scaffold proteins across Nucleocytoviricota, and/or (ii) virus-specific antivirals for mpox and ASFV. PSDisrupt’s translational goal is to design and advance lead compounds into preclinical validation and assess their commercial potential. We will: - Discover and design drugs by leveraging high throughput screens and deep learning-based algorithms. - Perform biophysical and cellular assays to validate compound efficacy. - Establish IP protection for novel inhibitors. - Engage with pharmaceutical and biotech partners for licensing and further development. By bridging virology and AI-driven drug design, PSDisrupt pioneers a novel antiviral strategy with broad applications beyond infectious diseases. The AI framework could be adapted to target phase separation in diverse pathological conditions, including cancer, neurodegeneration, and other condensate-associated diseases, significantly expanding its biomedical and commercial impact.
Ultrafast Cathodoluminescence Spectroscopy with Coherent Electron-Driven Photon Sources (UltraCoherentCL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-02-01
End date: 2025-07-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Exploring the optical responses of materials at the nanoscale is central to various fields of study, including quantum-sensitive measurement metrologies, photovoltaics, and optoelectronic devices. Electron probes have established themselves as important tools for visualizing nano-optical excitations with unprecedented spatial resolution. However, controlling optical excitations and exploring their decoherence dynamics require visualizing the dynamics of the nano-world at sub-femtosecond temporal resolutions. Within the context of our ERC Starting Grant "NanoBeam," we have established and proposed an electron-probe technique that not only allows us to explore dynamics at nanometer spatial and femtosecond temporal resolutions but also does so at a low cost. Unlike state-of-the-art ultrafast electron microscopy, our method does not rely on external laser excitations but rather on internal electron-driven photon sources. To visualize the decoherence dynamics in a variety of systems, including quantum emitters and networks, optical excitations of two-dimensional materials, and semiconducting optoelectronic devices, we plan to merge the electron-driven photon sources with a cathodoluminescence spectroscopy setup based on optical fiber technology. We will design piezo stages and sample holders that enable precise alignment and tuning of the sample, electron-driven photon sources, and fibers inside the microscope while efficiently collecting cathodoluminescence photons. Our electron-driven photon sources are designed to facilitate a high photon yield, allowing for optimal investigation of nonlinear processes. The instrument will be tested and verified for applications in mapping the decoherence dynamics of quantum emitters coupled to photonic structures, optical excitations in two-dimensional materials, and charge transfer dynamics in photovoltaic devices.

Keywords: cathodoluminescence ultrafast spectroscopy decoherence