Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
International Pregnancy Safety Study (InPreSS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2023-03-04
Duration (months): 30.0
Total project cost (EUR): 219875.52
EU funding (EUR): 219875.52
Participants: 2
Project status: CLOSED

This is a proposal for a global fellowship position within the International Pregnancy Safety Study (InPreSS), a recently established international collaboration based at the Centre for Pharmacoepidemiology, Karolinska Institute (CPE/KI), Sweden, between researchers in all five Nordic countries and the Harvard School of Public Health (HSPH), USA. The majority of pregnant women take prescription drugs but there is limited evidence of their efficacy and safety. InPreSS aims to conduct exceedingly important research into the risk and benefits of prescribed drug use during pregnancy. The overarching objective of this fellowship is to provide advanced training in reproductive pharmacoepidemiology while creating a platform from which to launch an independent academic career in the EU. Three specific aims are to: 1) investigate the efficacy/safety of prescribed drugs used treatment of diabetes during pregnancy; 2) to trial the InPreSS international research model to evaluate short- and long-term infant and maternal health outcomes following use of prescribed drugs for chronic disease treatment during pregnancy using an unparalleled global resources of over 5 million pregnancies; 3) provide experience and mentorship at HSPH to design and deliver courses in pharmacoepidemiology in Sweden. Aims will be achieved via an 18-month out-going phase at HSPH where the Fellow will use the latest methodologies in pharmacoepidemiology to analyze a dataset comprised of US health insurance data, and a 12-month return-phase at CPE/KI where the results will be combined using meta-regression techniques. The Fellow will receive the highest quality support while facilitating long-term partnerships, training the next generation of researchers, and contributing to the field with studies that will directly impact clinical practice and guidelines for pregnant women.

Keywords: pharmacoepidemiology,pregnancy,in utero exposures,treatment efficacy,diabetes,maternal health,teaching
advanced Concept for laser uplink/ downlink CommuniCation with sPace Objects (C3PO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Research and Innovation actions
Countries involved: Germany,Poland,Sweden,France,France,United Kingdom,United Kingdom
Call: Bottom-up space technologies at low TRL (H2020-COMPET-2014, 2014)
Start date: 2015-06-01
End date: 2017-09-30
Duration (months): 28.0
Total project cost (EUR): 1133017.5
EU funding (EUR): 999998.25
Participants: 8
Project status: CLOSED

C3PO: advanced Concept for laser uplink/ downlink CommuniCation with sPace Objects represents a radical improvement in performance of existing ground to low earth orbit communication systems in terms of weight reduction, on-board power consumption, data rate and communication security & confidentiality. C3PO in figures: - Mass reduction by a factor 14 - On-board power consumption reduction by a factor 100 - Data rate increase by a factor 2 The project's objectives are to - Design a solution to improve actual downlink and uplink communication systems based on a non-space disruptive technology - Improve enabling Space Surveillance & Tracking technologies performances to meet the final system needs - Increase the Multiple Quantum Well Technology Readiness Level from 2 to 4 - Improve the overall perfromance of space communication systems - Identify the C3PO system market and Business Model - Increase the system safety (including regulation and governance issues) This is achieved through an operational analysis of the final system, the validation of major system parameters through 2 experiments, the consolidation of the system architecturen the elaboration of the associated development roadmap and the definition of the system Business Model. The Multiple Quantum Well retro-reflector technology, derived from non-space domain, is incorporated into the current state of the art as a high-rate lightweight communication device. Its development in the space sector has a disruptive impact on the satellites and satellite imagery markets, enabling new missions such as CubeSat earth observations. The proposed project serve the Union's Common Security & Defence Policy by increasing the satellite communications security. C3PO mobilises traditional space actors and non-space actors such as TEMATYS (SME) and ACREO (Research).

Keywords: uplink downlink modulated retroreflector laser low earth orbit multiple quantum well
Pressure Unloading LVAD: An Explantable and Cost-Effective Bridge to Recovery in Heart Failure (PULVAD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Greece
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-31
End date: 2017-10-30
Duration (months): 24.0
Total project cost (EUR): 164653.2
EU funding (EUR): 164653.2
Participants: 1
Project status: CLOSED

The ability of the failing human heart to recover after mechanical unloading with left ventricular assist devices (LVADs) has been insufficiently exploited. To fill this void, we engineered the Pressure Unloading LVAD (PULVAD) system, designed to promote myocardial recovery. The overall objective of the proposed translational investigation is to evaluate the feasibility, safety and efficacy of this innovative pressure unloading approach as a bridge to recovery from heart failure. We will first investigate the effects of short-term PULVAD support on systemic hemodynamics and left ventricular mechanoenergetics in a large animal model of acute heart failure. We will then perform a pivotal randomized controlled study to investigate the safety and efficacy of long-term PULVAD support in promoting sustained cardiac recovery in a large animal model of chronic heart failure. If validated, this new technology has the potential to improve quality of life and ease the socioeconomic burden of advanced heart failure. In addition, histological, cellular and molecular analysis of paired myocardial biopsies obtained pre/post-PULVAD unloading will provide insight into mechanisms underlying cardiac reverse remodeling and myocardial recovery.

Keywords: mechanical circulatory support,left ventricular assist device,lvad,cardiac unloading,heart failure,remodeling,reverse remodeling
Quantifying the evolution of Earth's atmosphere with novel isotope systems and modelling (OXYGEN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-06-01
End date: 2021-11-30
Duration (months): 66.0
Total project cost (EUR): 1767455.0
EU funding (EUR): 1767455.0
Participants: 1
Project status: CLOSED

Atmospheric oxygen is fundamental to life as we know it, but its concentration has changed dramatically over Earth’s 4.5 billion year history. An amazing qualitative story has emerged, in which Earth’s atmosphere was devoid of free oxygen for the first 2 billion years of planetary history, with two significant increases in concentration at ~2.4 and ~0.55 billion years ago. Both oxygenation events were accompanied by extreme climatic effects – the “snowball earth” episodes – and paved the way for massive reorganization of biogeochemical cycles such as the Cambrian radiation of macroscopic life. Despite these profound influences on the Earth system, we currently lack fundamental quantitative constraints on Earth’s atmospheric evolution. I am poised to add substantial quantitative rigor to Earth’s atmospheric history, by constraining the concentrations of important gases (e.g., O2, O3, CO2, CH4, organic haze) in ancient atmospheres to unprecedented accuracy. I will accomplish this via an innovative interdisciplinary program focused on the unusual mass-independent isotope fractionations observed in sedimentary rocks containing sulfur and oxygen. These signals are direct remnants of ancient atmospheric chemistry, and contain far more information than can currently be interpreted. This project combines novel experimental and methodological approaches with state-of-the-art numerical modelling to significantly advance our ability to decipher the isotope records. A unique “early Earth” UV lamp coupled to a custom-built photocell will enable direct production of isotope signals under Earth-like conditions, with time-dependent sampling. Groundbreaking analytical methodologies will vastly increase the global geochemical database. The experimental results and data will provide ground-truth for next-generation atmospheric models that will constrain atmospheric composition and its feedbacks with the Earth-biosphere-climate system during key points in our planetary history.
The Legacy of Colonialism: Origins and Outcomes of Social Protection (COLSOC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-04-01
End date: 2024-03-31
Duration (months): 72.0
Total project cost (EUR): 1486250.0
EU funding (EUR): 37500.0
Participants: 2
Project status: SIGNED

Social protection has been one of the most popular instruments for promoting human development across the globe. However, the great majority of the global population is not or only partly covered by social protection. Especially in developing countries it is often the very poorest who do not receive essential social benefits. This is highly problematic since inclusive social protection is assumed to be a key factor for national productivity, global economic growth and domestic stability. Social protection in many developing countries can be traced back to colonial times. Surprisingly, the influence of colonialism has been a blind spot for existing theories and empirical studies of comparative social policy. In this project it is argued that the colonial legacy in terms of the imperial strategy of the colonial power, the characteristics of the colonized society and the interplay between the two is crucial in explaining early and contemporary social protection. Hence, the main objective of this project is to systematically understand how colonialism has shaped the remarkable differences in social protection and its postcolonial outcomes. Given the paucity of our information and understanding of social protection in former colonies, an interactive dataset on the characteristics, origins and outcomes of social protection will be developed including comprehensive data on former British and French colonies from the beginning of the 20th century until today. The dataset will be backed by insights derived from four case studies elucidating the causal mechanisms between the colonial legacy and early and contemporary social protection. The proposed project breaks new ground by improving our understanding of why social protection in some developing countries has led to more inclusive societies while reinforcing existing inequalities in others. Such an understanding is a prerequisite in informing the contemporary struggle against poverty and social inequality.
Gigstarter — A C2C Solution for Live Music Bookings (C2C4LMB)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

What if 741 million Europeans had an easy way to find an book affordable live music entertainment? 700,000 Independent EU artists, bands and DJs would perform more often; at least three times as much artists would be able to earn a living with music; and 50 million households would get access to what before was framed as a luxury service. 10,000 Booking requests since 2015 validate our concept: there is a demand for low budget live music bookings. Ordinary people don’t know where or how to find artists and the ones that can be found cost at least 1,500 euros. Interestingly, artists are in desperate need for more work but don’t know how to get more gigs. There is a systemic market barrier incapacitating non-contracted musicians. As a counterweight, Gigstarter has created a do-it-yourself infrastructure which empowers (private) clients and autonomous artists to find each other and get to an agreement easily. After testing our proposition in the Netherlands we've recently introduced our initiative in eight EU countries. The first international artists are subscribing, totalling 5,500 artists today. This year we expect to receive 4 million euros in local and cross-border booking requests. Gigstarter doesn’t ask a booking fee. Our goal is to internalise a large market; create real opportunities for our users and monetise on the professionalising tip using our infrastructure. The commercial viability has been tested locally in the Netherlands. Offer and demand use our system, growth is 100% per year and 8% of connected artists upgrades to a paid membership. This led to our break-even point in the Netherlands last year. Although further R&D is required, the basic IT system and online services are ready for scale-up. Scaling up to a 16% EU market-share will catalyse: 400 million euros in artist bookings; 930,000 concerts for local and private events and 35 million euros turnover by 2022. Let’s liven up Europe's latent live music potential.

Keywords: live music,entertainment,empowerment,accessibility,transparency,artist development,self service,online management,mobility,musical diversity,niche genres
Polarization and its discontents: does rising economic inequality undermine the foundations of liberal societies? (POLAR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2020-04-01
End date: 2025-09-30
Duration (months): 66.0
Total project cost (EUR): 2494665.0
EU funding (EUR): 2494665.0
Participants: 1
Project status: SIGNED

The project will examine the relationship between economic inequality and societal openness, one of the foundational elements of liberal society. Specifically, the project will provide new empirical evidence on the purportedly negative relationship between inequality and social mobility, support for democracy, and social cohesion in the West. The challenge addressed by the project is foremost empirical: for each dimension of openness, there are straightforward theoretical arguments to link rising inequality with declining openness. In each case, there is widely-known evidence to support a negative relationship in bivariate cross-sectional cross-country data. In each case, however, the best available research has regularly failed to confirm the negative relationships in longitudinal designs that sought to identify the causal impact from within-country changes in inequality. To possibly reconcile the discrepancies, the project will create four new multilevel databases that combine survey microdata across more than 30 countries and over observation windows possibly extending back to the 1970s to gain leverage for an encompassing and stringently longitudinal empirical analysis. The newly constructed databases will be used for a detailed decomposition of inequality trends, a disaggregated description of trends in social mobility, social cohesion and support for democratic governance, and for a differentiated causal analysis of the role of economic inequality for societal openness in the West. The latter rests on suitable multilevel regression specifications that distinguish between mechanical, power- and composition-dependent mechanisms and that involve temporal lags, effect thresholds, systematic treatment effect heterogeneity, and appropriate controls for concomitant trends in order to provide valid effect estimates, but also to contextualize effect occurrence and to possibly identify societal and institutional sources of resilience.

Keywords: economic inequality,social mobility,fairness,social cohesion,political participation,trust in institutions,cross national comparison,survey data,multilevel modelling,longitudinal research design
Intellectual Property Right Dashboard (IProBoard)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Germany
Call: New business models for inclusive, innovative and reflective societies (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

According to a PricewaterhouseCoopers (PwC) analysis, Europe risks losing the leadership in innovations. To protect innovations/inventions and to ensure the return on investment, intellectual property rights (IPR) are increasingly used. IPR processes are very complex, cost intensive and time consuming. Due to these facts, especially innovative entities (companies and universities) require very high efficient IPR management systems, which have not been existed on the market until now. The objective of EZN’s proposed innovation project “IProBoard – Intellectual Property Right Dashboard” is a business model, that contains a new service system, allowing the first time an efficient and individual IPR support for customer needs to significantly save efforts and costs and to simplify the sophisticated IPR management. The IPR data flood is reduced by IProBoard to an extract, which handles the main IPR figures in “one picture” (like a dashboard in a car) and allows a policy makers to decide intuitively in a very short time to realise maximised protection in combination with minimized costs. Each IPR can be managed by using IProBoard. Thus, the global potential market volume for IProBoard is up to hundreds of million Euro in an international field. Potential customers are all inventors, patent applicants and holders world-wide – preferentially hundreds of thousands of SME and additionally large enterprises and universities. First institutions have shown clear signals to EZN to purchase IProBoard, these are especially five German universities from Hannover, Brunswick, Clausthal and Berlin. So, IProBoard is very close to market and first sales (> 1.2 Mio Euro) are already possible with the market launch. IProBoard is developed by EZN due to the 35-year long term experience in the field of IPR. To exploit IProBoard, the main objectives for this feasibility study are evaluation of technical, economic and operational feasibility, schedule and the elaboration of a business plan.

Keywords: management,service,patents,trademark,monitoring,costs
The construction of objectivity - An international perspective on the emotive-cognitive process of judicial decision-making (JUSTEMOTIONS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Italy,Sweden,United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-09-01
End date: 2023-08-31
Duration (months): 60.0
Total project cost (EUR): 1499671.0
EU funding (EUR): 1455735.57
Participants: 3
Project status: SIGNED

This project is the first comprehensive study of how objectivity is construed in different legal systems, in Sweden, Scotland, USA and Italy. Objectivity is operationalised as the applied emotive-cognitive process of judicial decision-making. This definition challenges the prevailing positivist legal notion of objectivity, which implies a separation of emotion/reason as opposites. Previous research has shown this dichotomy to be problematic; reason depends on emotions and ’feeling’ the consequences of alternative action is fundamental to form rational decisions. For legal actors this means that objective decision-making relies on emotional information and that sensibilities influence allocation of culpability. Through a comparative multi method qualitative design (court observations, shadowing, interviews and text analyses) we will follow criminal cases from prosecution, lower court, to the court of appeal focusing on: 1) The emotive-cognitive construction of objective decision-making; 2) Dimensions of encoding subjective lay narratives in a legal case into objective judicial categories; 3) Emotive-cognitive components of changed decisions. By contrasting the judicial decision-making process in different legal systems (common and civil criminal law) and in varying emotional regimes (e.g. subtle Swedish regime, outspoken American regime), we will dissect differences and similarities in the construction of objectivity in countries that all share the ideal of judicial dispassion. The project is path breaking by addressing problems with relying on a positivist notion of objectivity which tends to preclude legal actors from reflecting on how they do use emotions at work, thereby obscuring when personal sensibilities interfere with professional decisions. Since judicial objectivity serves as the quintessence of rational decision-making, this project will be of applied as well as theoretical relevance in the understanding of rational action outside of the legal context.

Keywords: objectivity,sociology of emotion,decision making,judge,prosecutor,criminal cases,empathy,emotional regime,rationality,power,qualitative design,international comparison,interdisciplinary