Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DNA replication at the heart of cell fate decisions and cancer development (RepliFate)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Denmark,Germany,Greece,Switzerland,Netherlands,France
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 2761972.46
EU funding (EUR): 2650312.8
Participants: 21
Project status: SIGNED

RepliFate is doctoral network designed to train the next generation of European researchers in the field of DNA replication, cell fate and cancer. We have designed an innovative training program that aims at providing interdisciplinary and intersectoral formation for the fellows. We base the network in inclusion, creativity and communication as the base to train the researchers in all aspects of scientific activity. RepliFate will investigate the mechanisms through which changes in DNA replication influence cell identity, respond to different kinds of stress, and prevent malignant transformation. We will put DNA replication at the center stage as the driver of these processes and not a mere bystander, using recent technological to better understand the role of DNA replication as a determinant of cell fate and cancer. RepliFate links academia with industry and society and will provide new opportunities for innovation in one of the main societal challenges in human health, cancer. The scientific roots of RepliFate are set on the Horizon Europe Mission Cancer objectives Understand and Optimise. We will pave the way for the development of innovative cancer treatments exploring the links between DNA replication and cell fate, the immune response and unscheduled cell proliferation. RepliFate is composed by 10 European beneficiaries (9 from academia and 1 from industry) along with 2 Swiss associated partners (with their own funding from the Swiss government), 4 companies, 1 news agency and 2 non-profit organizations as associated partners from 8 different countries. Putting the focus on the fellows, we have combined our expertise to create an outstanding training program with the objective to generate leaders in the field with independent and out-of-the-box views to drive the knowledge of basic science to applications that will improve the resilience of the European society by positively impacting on our response to the huge health challenge constituted by Cancer.

Keywords: dna replication,cell fate,cancer,inflammation,ubiquitin,cell identity,replication stress,dna repair
deVEloping scientific Research with ethIcs and inTegritY (VERITY)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Research and Innovation actions
Countries involved: Ireland,Germany,Austria,Cyprus,Greece,United Kingdom
Call: Societal trust in science, research and innovation (HORIZON-WIDERA-2021-ERA-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 1847563.75
EU funding (EUR): 1847562.0
Participants: 8
Project status: SIGNED

Different "machines of trust" in science have been identified in the literature: research ethics, research integrity, science communication, benefit sharing and technology assessment. Previous EU funded projects have focused on particular actors of the trust in science ecosystem (e.g. scientists, research funding organisations, research ethics committees) to explore the impact of particular "machines" (e.g. science communication, research ethics). VERITY goes beyond the state of the art by conceptualising "stewards of trust" as the actors of the ecosystem that are responsible for upholding societal trust in science and facilitating science-society co-creation, either this refers to formally responsible organisations like research funding organisations and higher education institutions, or it refers to de facto responsible organisations like social media companies and video streaming platforms which influence societal perceptions of science and innovation. VERITY combines multidisciplinary expertise, both from the social sciences and engineering, to synthesise existing knowledge to evaluate tools and methods for enhancing trust in science through original research and small-scale participatory activities, before producing the VERITY Protocol of Recommendations for "stewards of trust". VERITY brings forward interdisciplinary expertise to perform network analysis and execute interventions on social media, to validate the VERITY Protocol and alleviate practical barriers for its uptake in practice by different stakeholders. VERITY findings will be widely disseminated to different "stewards of trust", such as policymakers, research funding and performing organisations, higher education institutions and other research and innovation actors, to enhance societal trust in science and facilitate science-society co-creation.

Keywords: trust,mis trust in science,stewards of trust,open science,co creation,citizen science
Reconstructing the Molecular Evolution of Non-Shivering Thermogenesis (EVOTHERM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Sweden
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2485587.5
EU funding (EUR): 2485587.5
Participants: 1
Project status: SIGNED

Non-shivering thermogenesis (NST) is one of the most fascinating evolutionary achievements, enabling high body temperatures and successful radiation of mammals and birds into cold environments. Yet, the evolutionary origin and molecular innovations enabling NST are unknown. Using comparative approaches, my laboratory has recently transformed our view on mammalian NST by demonstrating that the thermogenic function of the mammalian heater protein, uncoupling protein 1 (UCP1), has only emerged late during mammalian evolution in the stem placental ancestor. With this ground-breaking framework, I aim to reconstruct the molecular innovations of UCP1-based NST in placental mammals, and explore the unknown molecular basis of NST in non-placental mammals and birds, thereby advancing our understanding on the evolution of thermogenesis in vertebrates. Specifically, I will 1) Determine critical structure-function motifs of UCP1 that enabled heat production and that have been tuned through placental species radiation to adapt thermoregulatory demands of various ecological niches; 2) Characterize molecular networks governing NST on an evolutionary scale by comparative transcriptomics of extant placental and marsupial heater organs; 3) Explore alternative thermogenic mechanisms in marsupials; 4) Delineate the functional evolution of muscle-based NST in amniotes by reconstructing ancestral key variants of sarcolipin, the proclaimed key player of muscle thermogenesis. In addition to cutting-edge molecular and bioenergetic techniques for assessing thermogenesis, which we have all mastered in my laboratory, our reconstruction of ancestral thermogenic proteins allows us to look back hundreds of millions of years into the evolutionary past of vertebrate thermogenesis. To identify unknown thermogenic mechanisms and consolidate them in vivo, we take advantage of the latest Crispr-CAS technologies to generate unique non-model organisms, such as the first UCP1 knockout marsupial.

Keywords: mammalian avian thermogenesis,non model organisms,metabolism,ucp1,mitochondrial efficiency,cellular thermogenesis,evolution of endothermy
Local Heroes, Global Impact: The Unsung Power of Micro and Small Enterprises in Global Value Chain Reconfiguration (SOS-GVC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 1248100.0
EU funding (EUR): 1248100.0
Participants: 1
Project status: SIGNED

Recent geopolitical and economic shocks have led to a profound transformation in global production processes. In response, many companies are restructuring their operations by relocating business activities closer to or within their home countries. This shift is altering the dynamics of Global Value Chains (GVCs), intricate networks that are central to producing a variety of goods. While scholarly attention focuses on large multinational firms, the role of Micro and Small Enterprises (MSEs) in GVC reconfiguration remains an unexplored frontier. SOS-GVC aims to introduce a pioneering theoretical and empirical framework to assess the role of MSEs in reshaping GVCs structure, with a focus on the territorial implications of their strategies. The project will provide evidence of the various ways MSEs can influence global production processes. Firstly, MSEs directly involved in GVCs can repatriate offshored activities, generating impacts in the domestic regions where they are located. Secondly, MSEs indirectly participating in GVCs can safeguard local subcontracting networks by implementing risk prevention strategies to reduce the likelihood of disruptive events. The combined effect of these actions can empower the territories where MSEs operate, enhancing their ability to react to shocks. To construct the empirical framework, I will employ distinctive georeferenced firm-level data obtained from the Italian Ministry of Economy and Finance Annual Survey covering the 2010-2022 period. This database, untapped by the academic community, provides a unique advantage. The project has significant societal implications. As deglobalization trends persist, the crucial role of MSEs in GVCs is expected to grow, along with the regional impact of their activities. The societal impact lies in fostering a nuanced understanding of the intricate interplay between MSEs, GVC, and regional resilience, informing policymakers and stakeholders in navigating the evolving global economic landscape.

Keywords: regional science,global value chains,micro and small enterprises,regional resilience
AI-Augmented Software Engineering for Intelligent Robotics (ASTIR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Germany,France,United Kingdom,Spain,Portugal,Cyprus
Call: Fundamentals of Software Engineering (RIA) (HORIZON-CL4-2024-DIGITAL-EMERGING-01, 2024)
Start date: 2024-12-01
End date: 2027-11-30
Duration (months): 36.0
Total project cost (EUR): 5748269.58
EU funding (EUR): 4899978.06
Participants: 10
Project status: SIGNED

In today's Europe, software is pivotal for societal progress, deeply ingrained in our lives, and essential for the EU's competitiveness. The European Commission's Digital Strategy positions software at the heart of digital transformation, targeting a sustainable economy and broad digital tech benefits. This era underlines software engineering's crucial role in creating functional, reliable, and efficient software systems. The advent of AI, especially in robotics, poses new challenges, demanding a rethink of traditional software engineering. The engineering of robotics faces ongoing issues such as complex operational states, environmental unpredictabilities, and critical safety needs. These are amplified by the diversity in robots, use cases, AI technologies, and development settings, calling for a significant evolution in robotics software engineering. The rise of intelligent robots, with their ability to learn, adapt, and make independent decisions, highlights the need for improved engineering tools and methods. ASTIR aims to address these challenges by developing an AI-augmented engineering workbench for intelligent robotics software, supporting all lifecycle phases from requirements engineering to system maintenance. This workbench, leveraging trustworthy generative AI, aims to integrate with current engineering practices, enhancing collaboration and productivity. ASTIR will validate the technological offering in 3 novel and open-access use cases targeting diverse robotics markets, namely service robotics, manufacturing robotics, and drones.

Keywords: ai,generativeai,llm,robotics software engineering
Enhanced Safe and Sustainable coatings for supporting the Planet (PROPLANET)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Spain,Slovenia,Norway,Portugal,Cyprus,Netherlands,Greece,Italy,United Kingdom
Call: Safe- and sustainable-by-design organic and hybrid coatings (RIA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2023-01-01
End date: 2026-04-30
Duration (months): 40.0
Total project cost (EUR): 4998571.25
EU funding (EUR): 4998570.75
Participants: 14
Project status: SIGNED

PROPLANET addresses novel coating materials solutions, tackling the problem from a sustainable-business perspective, enabling overcoming the barrier for environmental protection, safety, chemical improvements, and circular value chains. The main goal of PROPLANET is to design and optimise 3 innovative coatings for industrial sectors: textile, food-packaging, and glass. 1)Crosslinked biopolymer oil/wax microcapsules in polysaccharide matrix (hydrophobic, olephobic bio-based coating) 2) Hybrid siloxane biobased coating (non-stick and anticorrosion protection bio-based hybrid coating) 3) Hybrid siloxane coating (anti-soiling (AS) anti-reflecting (AR) hybrid coating). The value chain of each product is optimised from raw material source to End Of Life of products, ensuring the circular economy. All coatings are designed based on Safety and Sustainability by design (SSbD) concepts and optimised with mathematical computational tools such as first-principles-based models, in silico models, environmental fate models, and sustainability assessment. On top of that, replication activities aided by a powerful PROPLANET Replication tool based on data-driven algorithms and multiobjective optimization (MO) will promote the integration of the novel coatings on different applications, supporting their route to market, operating at different conditions, and following an Eco-design thinking. A well-balanced consortium, covering all actors in the , formed by end-users, technology solution providers and research organizations, ensures the successful achievement of objectives, which will allow a wide-spreading replication strategy towards efficient and safe designs for new coatings.

Keywords: safe and sustainable by design,in silico toxicological modeling,first principle based models,environmental fate models,data driven algorithms,bio based coatings,hybrid coatings
Sustainable Chemistry with Iodine Reagents (SUSCIR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2014-07-03
End date: 2016-07-02
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

Hypervalent iodine reagents allow transformations under very mild reaction conditions. They are not only environmentally friendly oxidizing agents used in a wide range of transformations, but can also serve in highly selective asymmetric transformations which can be easily achieved using these reagents. The development of novel asymmetric metal-free transformations will lead to novel and powerful stereoselective protocols. Such advancements are still very much sought after for many transformations in organic synthesis and will be used by the fine chemical and pharmaceutical industries. The challenge of developing new metal-free approaches with chiral hypervalent iodine reagents is considerable as efficient procedures of this type are still in their infancy. We will develop novel and efficient enantiomerically pure hypervalent reagents/catalysts for such reactions. Iodonium ylide chemistry and utilization of suitable chiral iodonium ylides will be developed for the metal-free carbene transfer from iodonium ylides to carbon – nitrogen double bonds. Along with the successful development and application in asymmetric transformations, we will focus on the continuous-flow synthesis of complex molecules in which iodine reagent oxidation is one of the key steps. Self-optimization of reaction conditions through incorporation of analytical methods will be pursued.

Keywords: organic chemistry,chemical reactions,catalysis
Understanding the Concept of Self as a Phenomenal Concept (PHENOSELF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-04-27
End date: 2017-04-26
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Each subject uses a concept of self (or ‘I’) to reflect on and store information about herself. Possessing this concept, and thus being able of explicit self-representation, is arguably what makes a creature a fully-fledged self, or subject. The fundamental hypothesis of the proposal is that this I-concept is interestingly akin to phenomenal concepts (i.e. those concepts, like “red”, “shrill” or "painful" we use to describe how our experiences feel to us). The key research questions that this new theory is designed to answer are: (1) What is the semantics of the self-concept, i.e. what representational mechanism do we deploy to refer to ourselves through it? (2) How does the proposed semantics help solve some open philosophical issues concerning the self-concept? These include issues (2a) in epistemology; (2b) in the metaphysics of persons and moral philosophy. (3) What further implications does the proposed semantics have for issues raised by the self-concept in neighbouring disciplines, such as cognitive psychology, neuropsychology and psychopathology? (1) I propose a new semantics for the I-concept, conceived for the first time as a special type of phenomenal concept; this semantics is inspired by that of a class of linguistic expressions called indexicals. (2a) On this basis, I transpose what is known about phenomenal knowledge to the case of self-knowledge. (2b) The theory also suggests a new account of what grounds the special value we ascribe to persons as such, and why subjects care about their own survival through time. (3) I argue that psychiatric troubles (e.g. schizophrenia, Cotard syndrome) affecting personal identity and the mastery of ‘I’ come from a dysfunction of the phenomenal “sense of self” I posit to explain how we can come to acquire a self-concept.

Keywords: s210 philosophy,s211 epistemology,interdisciplinary links in linguistics and cognitive psychology,subjectivity,concept of self,sense of self,phenomenal concepts,indexicality,autonymy
Spatiotemporal Distribution and Structural impact Loading due to Artificial Debris Objects in Violent Flows (IMPLOADIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-07-01
End date: 2017-06-30
Duration (months): 36.0
Total project cost (EUR): 252244.8
EU funding (EUR): 252244.8
Participants: 1
Project status: CLOSED

Hazardous violent free surface flows are regularly observed at coasts in connection with storm surges or tsunami and inland in connection with embankment / dam failure. At these instances, the motion of the water results in the pick up of (artificial) debris either directly from the ground or after destroying man-made infrastructure which lies in the pathway of propagation. That debris is advected by the flow over significant distances. In this regard it is unknown how single debris objects are picked up and how they eventually distribute spatiotemporally within the front of such a bore that is propagating over dry or wetted ground. It is equally unknown how large the forces of multiple debris are that exert to man-made structures with respect to the actual debris-burden in the bore front. Few guidelines exist to incorporate floating or submerged debris into design and no evidence is given for multi-object impact. Therefore, the stated questions will be studied by experimental and numerical means. Experiments will be based on dam-break and very long waves which may reproduce natural flows in a laboratory. Distribution of debris and the pick up process will be measured by means of innovative techniques (accelerations/inclinations and radio waves) in conjunction with a SME. Measurement of forces will allow for correlation of multi-object impact and structural loading. In addition, the meshless numerical tool "smoothed particle hydrodynamics" will be applied to reproduce laboratory conditions for validation. The tool will be enhanced in order to account for the pick up of debris objects from the ground. This will enable the simulation of additional impact/load combinations. Eventually, it is hoped for the development of engineering design formula to predict appropriate structural loadings in order to contribute to the safety and stability of buildings as well as to help mitigating natural hazard effects.

Keywords: violent flow,dam-break,bore,impact loading,debris,tsunami,storm surge,flash flood,bore front,3d object tracking,rfid,inertial measurement unit imu,risk assessment,hazard mitigation