Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A holistic frameWork with Anticounterfeit and inTelligence-based technologieS that will assist food chain stakehOlders in rapidly identifying and preveNting the spread of fraudulent practices. (WATSON)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Ireland,France,Italy,Greece,Finland,Germany,Norway,Portugal,Luxembourg,Spain,Cyprus,Slovenia,Türkiye,Belgium,Austria,Bulgaria,Denmark,Switzerland,United Kingdom,Hungary
Call: Effective systems for authenticity and traceability in the food system (HORIZON-CL6-2022-FARM2FORK-01, 2022)
Start date: 2023-03-01
End date: 2026-02-28
Duration (months): 36.0
Total project cost (EUR): 9744008.25
EU funding (EUR): 9744008.25
Participants: 50
Project status: SIGNED

WATSON provides a methodological framework combined with a set of tools and systems that can detect and prevent fraudulent activities throughout the whole food chain thus accelerating the deployment of transparency solutions in the EU food systems. The proposed framework will improve sustainability of food chains by increasing food safety and reducing food fraud through systemic innovations that a) increase transparency in food supply chains through improved track-and-trace mechanisms containing accurate, time-relevant and untampered information for the food product throughout its whole journey, b) equip authorities and policy makers with data, knowledge and insights in order to have the complete situational awareness of the food chain and c) raise the consumer awareness on food safety and value, leading to the adoption of healthier lifestyles and the development of sustainable food ecosystems. WATSON implements an intelligence-based risk calculation approach to address the phenomenon of food fraud in a holistic way. The project includes three distinct pillars, namely, a) the identification of data gaps in the food chain, b) the provision of methods, processes and tools to detect and counter food fraud and c) the effective cross border collaboration of public authorities through accurate and trustworthy information sharing. WATSON will rely upon emerging technologies (AI, IoT, DLT, etc.) enabling transparency within supply chains through the development of a rigorous, traceability regime, and novel tools for rapid, non-invasive, on-the-spot analysis of food products. The results will be demonstrated in 6 use cases: a) prevention of counterfeit alcoholic beverages, b) preservation of the authenticity of PGI honey, c) on-site authenticity check and traceability of olive oil, d) the identification of possible manipulations at all stages of the meat chain, e) the improved traceability of high-value products in cereal and dairy chain, f) combat of salmon counterfeiting.
Integrated Quantum Network Node using Chip-based Qubit Devices (InQubate)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: Transition Open 2024 (HORIZON-EIC-2024-TRANSITION-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Computer networks have had a profound impact on humanity, fundamentally changing our everyday lives. Akin to these ‘classical’ networks, quantum networks will distribute quantum information, thereby leveraging unique quantum advantages for applications which provably outperform any classical approach. The mission of Delft Networks is to develop the technology and services that unlock the large societal and economic potential of general-purpose quantum networks. Building on world-leading research and a strong IP foundation, InQubate will position us to execute proof-of-concept use-case demonstrations that link to concrete user demands and that use scalable technology. To reach this stage, we will build a full-stack integrated quantum networking node using chip-based networking qubits. Reconfigurable optical links between its qubits will enable its use as a development and use-case testbed for various relevant network topologies. In doing so, we will exploit our recent breakthroughs in diamond networking qubits, optical device packaging, and quantum network software architectures, and push these to TRL6 at system level. In conjunction, our business objective aims to translate well-known conceptual advantages of quantum connectivity to concrete use-cases that create real value for industry and society. We will achieve this by combining expertise in application protocol development with connections to relevant industry, providing a bespoke application co-development process. Achieving the tech objective will provide a complete system to engage with end-users in co-developing solutions that create value, while the outcomes of the use-case work will provide continued feedback to steer tech development to the needs of end-users. Achieving the objectives will allow us to capitalize on our innovations and expertise, unlocking future markets and investments, and will provide Europe with a leading industry player in this emerging strategic market.

Keywords: quantum internet,qubits,entanglement,quantum networks,quantum communication
Packaging of novel Ultra-dyNamiC pHotonic switches and transceivers for integration into 5G radio access network and datacenter sub-systems (PUNCH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Innovation actions
Partnership: Photonics (co-programmed)
Countries involved: Belgium,Netherlands,Israel,Italy,Austria,Germany,United Kingdom
Call: Advanced optical communication components (Photonics Partnership) (IA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 4895597.23
EU funding (EUR): 4274284.38
Participants: 8
Project status: SIGNED

PUNCH offers a solution for time-deterministic and time-sensitive networks by developing a new optical switching paradigm which (I) breaks the trade-off between flexibility (ultra-dynamic reconfigurability) and determinism (guaranteed latency and jitter) by offering an all-to-all reconfigurable interconnect; (II) reduces congestion by activating bandwidth steering so that additional capacity can be allocated between hot nodes in the network; (III) provides unparalleled dynamics and bandwidth efficiency by further enabling multiplexing in the time domain with fast reconfigurable capability. A 2×2×8Lambda wavelength selective switching element will be scaled to a fully non-blocking 8x8x8Lambda and 16x16x8Lambda reconfigurable optical switch fabric. The development of a micro-transfer-printing process for semiconductor optical amplifiers enables loss-less optical switching on a silicon photonics platform. Custom configuration electronic ICs to actuate, control, and power-monitor a scaled switch fabric will be densely integrated with the photonic ICs into a heterogeneous fanout wafer-level package, processed on a 200mm reconstructed wafer platform. In addition, the optical interfacing to the photonic ICs will be accomplished using an optical redistribution layer, providing an optical fanout on high-density organic substrates, and allowing for a scalable optical fiber packaging solution. The novel integration and packaging processes will be applied for manufacturing 1.6 Tbit/s optical transceivers providing the interface between optical switches and electronic resources (compute, memory, and storage). The optical switch and transceiver prototypes will be demonstrated in a 5G RAN Transport Network, for TSN Fronthaul applications and for memory disaggregation in data centers.

Keywords: optical switching,time deterministic and time sensitive networks,radio access network,disaggregated data center
Shedding new light on Privately Owned Public Spaces (POPS) to improve social inclusion: facilitating POPS for youths’ social activities (POPS for Youth)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-15
End date: 2026-07-14
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

This study addresses multifaceted challenges in enhancing the inclusivity of Privately Owned Public Spaces (POPSs) in urban contexts, particularly for youth. Young people often encounter limitations in their social engagement due to financial constraints and restrictions on adult-oriented venues. Despite their potential, POPSs’ role as inclusive and vibrant spaces for youths remains unexplored, revealing gaps in inclusive tools and comprehensive analyses of this relatively new type of public space in Dutch cities. This research introduces an innovative user-centric approach that effectively addresses varying social needs. Rooted in Ecological Psychology, the approach incorporates the concept of affordances - the opportunities for action provided by the environment, examining the interaction between the built environment and individuals’ action capabilities. By integrating affordances with levels of social interactions in public spaces, the project aims to develop a methodological framework to evaluate POPSs’ social inclusiveness for youth. This framework investigates the intricate interplay between user capabilities, social interactions, and the built environment. It develops, tests, and validates an affordance-based evaluation model based on information synthesised from observations, behavioural mapping and tracking of users in five case studies in Dutch cities. The project’s outcomes will be communicated to city officials, property managers, urban designers, and planners through the POE framework and an innovative “Gray Map” that visually represents the degree of accessibility and inclusiveness within POPSs for different user types. This project contributes to developing more inclusive urban environments that cater to diverse user groups, particularly youth, ultimately advancing urban social well-being within public spaces. So all youth feel safe, accepted, and free to participate in urban life, increasing social, mental, and physical health for all youths.

Keywords: public spaces,privately owned public space pops,social interaction,inclusiveness,affordances
Engineering the immunosuppressive microenvironment in mesothelioma with targeted LipidNanoParticles encapsulating self-amplifying RNA (OncoNanoR)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-01-01
End date: 2025-06-30
Duration (months): 30.0
Total project cost (EUR): 215773.2
EU funding (EUR): 215773.2
Participants: 2
Project status: CLOSED

Malignant pleural mesothelioma (MPM) is a highly aggressive disease, where chemotherapy remains the standard of care, enabling an overall survival (OS) of 12 months. Anti-PD-1-based immunotherapy has not improved the patient's OS, while providing only a response rate of 21%, owing to the immunosuppressive tumor microenvironment. The originality of this proposal relies on engineering a novel form of immunotherapy for the treatment of MPM, through activating the innate and adaptive tumor microenvironment, upon one single intravenous injection of self-amplifying RNA, intracellularly delivered by a targeted LipidNanoparticle, which has recently proven to successful target small drugs to orthotopic MPM. This proposal challenges a major dogma in onconanomedicine – targeting nucleic acids to extra-hepatic tumors - where I will have the guidance of Prof. Moreira from CNC, UC, who holds more than 25 years of experience in the field of targeted delivery to solid tumors, being a successful entrepreneur. Supervision will be complemented with the guidance of an immunologist (APaiva), clinical pathologist (ACarmo), expert on physical-chemistry of colloids (BSilva) and drug development (Sérgio Simões, supervisor at Bluepharma Pharmaceutical Industry). This Marie Sklodowska-Curie European Fellowship, in line with Europe Mission on Cancer, is a life time opportunity to gain a number of different transferable skills, mentoring and leadership, networking and knowledge dissemination, exploitation and communication. These will enable me to become a highly qualified researcher, able to generate and integrate differentiated and interdisciplinary knowledge, and with know-how on how to translate it towards the market and the patients. As such, a wide avenue of opportunities will be open to further pursue a career either in Academia as Principal Investigator/Group Leader or Senior Scientist in the R&D department of a company dedicated to cancer immunotherapies and/or complexes injectables.

Keywords: targeting,lipid nanoparticles,self amplifying rna,tumor microenvironment,mesothelioma
Characterising thermal stress response in passerines: from underlying mechanisms to evolutionary consequences. (HotPasserine)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2026-01-31
Duration (months): 28.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: SIGNED

Our ability to quantify and predict the magnitude of environmental global changes effects represents one of the major challenges of the 21st century. These changes are characterised by a a gradual increase of ambient temperature through time, but also leading to an increased frequency of climate anomalies, such as heat waves. Habitat urbanisation, in particular, is a key driver of the increase of ambient temperature. These temperature changes can drastically modify the phenology of species, their geographic distribution, food webs, interspecific interactions, but also life history trajectories, behaviour and physiology of individuals. Yet endotherms capacities to adapt to thermal stress remain poorly understood. The aim of this project is to evaluate the harmful repercussions of thermal stress on the physiology of organisms, and on their life history trajectories (reproduction and survival). Using a multidisciplinary and integrative approach, I plan to conduct two experiments on Great tits to assess the effects of thermal stress on different molecular and physiological mechanisms (metabolic rates, mitochondrial function, markers of ageing, stress, Hsp expression) by manipulating temperature (increase, decrease, mis-match) under common garden conditions, during development and growth period and follow various life history traits such as growth and survival patterns. This project will provide exceptional insights to characterise variation of individuals’ life history trajectories and physiological responses to thermal stress and unusually warm temperatures; such results will be key to pinpoint the mechanisms linking thermal changes to any potential effects on life-history trajectories, which is crucial to monitor organisms’ responses to climate change. We hope that this work will help to assess the fitness prospects of wild animals and potentially to predict extinction risks of animal populations in the context of global changes.

Keywords: thermal stress,body temperature,life history trajectories,metabolism,physiology,behaviour,stress,ageing,birds,climate change
Unleashing Cellulose Potential: Laser-Driven Structural Modulation (LaserCell)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499969.0
EU funding (EUR): 1499969.0
Participants: 1
Project status: SIGNED

LaserCell envisions an innovative approach to reshape and rearrange cellulose at the molecular level by disrupting cohesive interactions through resonant excitation of specific bonds. It will revolutionize the field of biopolymer processing beyond cellulose and yield fundamental insights into supramolecular structure and dynamics in biomaterials. Although cellulose is biodegradable and mechanically strong, it cannot be processed by conventional thermoplastic polymer methods, which limits its use as high-volume material. Cellulose decomposes before it melts because of cooperative intermolecular hydrogen bonding and hydrophobic interactions. To plasticise cellulose, I propose to disrupt these intermolecular bonds with photon energy delivered by infrared (IR) laser pulses. Employing wavelengths matching specific vibrational modes, the photon energy will be resonantly absorbed, thus effectively plasticising cellulose. I envision that the rapid energy dissipation in short pulses will deliver enough peak power to disrupt the intermolecular bonds yet avoiding thermal damage. I plan to systematically investigate how laser parameters influence the supramolecular structure of cellulose and establish analytical tools to characterize its structural transitions under mechanical load. Additionally, to allow processability in different set-ups, I aim to prolong the time window of plasticization and adjust the flowability, by using the laser irradiation in synergy with the hydrogen disrupting molecules. As a proof of concept, I will implement this novel photo-plasticization technique into a cellulose fibre spinning process and post-treatment to modulate the cellulose fibre crystallinity. I have worked for 10 years on cellulose-based materials and have a strong background in fibre spinning and material science. My research group will engage 1 PhD student and 2 Postdocs with background in polymer science and laser physics and technology.

Keywords: cellulose,biopolymer processing,thermoplastic,fiber spinning
Plasma-ACtivated hydroGEL: new frontiers solutions in cardiac regenerative medicine (PACGEL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: CLOSED

Heart diseases represent the main leading cause of mortality in EU and other industrialized countries. The development of minimally-invasive therapies to treat cardiovascular injuries is the subject of intense investigation by the cardiac regenerative medicine community. Moreover, in vitro models of human cardiac pathological tissues mimicking disease-specific oxidative conditions are demanded for understanding pathological mechanisms at different disease stages, and for the development and preclinical validation of novel therapies, at reduced costs and in compliance with 3Rs (Reduction, Refinement, Replacement) principle. PACGEL aims at the design of novel plasma jet-activated hydrogels based on biocompatible polymers, to be exploited as: (i) injectable stimulating systems to promote cardiac tissue regeneration and (ii) in vitro models of diseased cardiac tissue with tunable oxidative conditions. The biological effect will depend on the doses and types of reactive oxygen and nitrogen species encapsulated in the hydrogels, modulated by the plasma jet treatment parameters. The objectives are: (1) to identify the minimal reactive species concentration (threshold limit) above which oxidative effects prevail, by in vitro tests with relevant human cardiac cells; 2) to develop plasma jet-activated hydrogels with regenerative potential; 3) to design in vitro 3D bio-printed tissue models mimicking different stages of human cardiac diseases. My expertise in Plasma Medicine and Chemistry, the supervisor’s consolidated competence in biomaterials design, tissue engineering and cardiac regenerative medicine, my proof-of-concept preliminary results and the availability of all the needed facilities and training opportunities at the Host Institution will ensure the research progress. Furthermore, PACGEL will address one major societal challenge such as the treatment of age-related cardiac diseases exploiting green technologies, thus achieving still a greater impact on society.

Keywords: cardiac regenerative medicine,plasma jet,reactive oxygen and nitrogen species,hydrogels,bio printed tissue models