Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unveiling lung resilience mechanisms: a ground-breaking way to cope with air pollution (KINTSUGI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-07-01
End date: 2030-06-30
Duration (months): 60.0
Total project cost (EUR): 1999905.0
EU funding (EUR): 1999905.0
Participants: 2
Project status: SIGNED

Air pollution, exacerbated by heatwaves and wildfires, affects primarily the lungs, leading to potentially life-threatening effects eluding conventional treatments. In response, KINTSUGI adopts a new perspective by exploring lung resilience mechanisms, to understand how respiratory health is maintained in most individuals: drawing on evidence from both a broad evolutionary standpoint, where humans have evolved in environments exposed to particles and proofs of lung resilience observed particularly in smokers, it seeks to redefine the paradigm of investigating lung response to particulate pollution. For that, KINTSUGI focuses on the airway submucosal gland (SMG), an ectodermal appendage lining the airways, renowned for its unique properties in mucus secretion, antimicrobial activity and a potential niche for proximal airway stem cells. The hypothesis posits the airway SMG as a crucial signalling hub, orchestrating responses to external perturbations to ensure proximal lung resilience. Using dissected clinical samples of SMG, it aims to unravel cell interactions intricacies within this niche, ultimately generating a "SMG-related resilience signature". Additionally, 3D in vitro models replicating the in vivo architecture and function of airway SMGs will be established for the study of mucociliary clearance, antimicrobial activity, and regeneration studies under both homeostatic conditions and particles exposure. KINTSUGI further integrates probabilistic mathematical modelling, considering microscopic interaction rules within the SMG, to elucidate macroscopic behaviours underlying lung resilience at different time scales. KINTSUGI anticipates impacting broader scientific communities, as such health, biology, and evolution, by uncovering fundamental insights into the mechanisms governing resilience. The impact on health and its potential to resonate across diverse scientific disciplines positions KINTSUGI as a ground-breaking initiative with far-reaching implications.

Keywords: lung resilience,particulate pollution,airway submucosal gland,lung organoid
Absorb Nearby Tidy Identified Candidates for Ideal Parteking Available Temporal Extra-capacity (ANTICIPATE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Spain,Italy,Germany,Belgium
Call: ATM Excellent science and outreach for capacity on demand and dynamic airspace (HORIZON-SESAR-2023-DES-ER-02, 2023)
Start date: 2024-09-01
End date: 2027-02-28
Duration (months): 30.0
Total project cost (EUR): 1114307.5
EU funding (EUR): 977515.0
Participants: 6
Project status: SIGNED

Besides the Air Traffic Flow and Control Management (ATFCM) benefits achieved through the implementation of STAM mechanisms, the fast pace time-variant dynamic characteristics of traffic during the execution phase cannot be counterbalanced by the rigidity (technical, staff or set-up time requirements) of low pace airspace capacity mechanisms diming the possibility to implement efficient and effective “capacity-on-demand” measures where and when they are needed. ANTICIPATE aims to extend pre-tactical and tactical ATFCM STAM with a "capacity-on-demand" efficient and effective mechanism to benefit of the networking airspace capacity by a fine tuning distribution of workload among adjacent sector ATCos at execution phase. It aims to avoid the unnecessary regulations on the traffic demand on the day of operation while mitigating present latent capacity inherent to a fragmented management of sectors through a network-minded management of time-stamp perishable mobile areas among sectors. Present proposal rely on the ATM digitalization and the Virtual Centres to enhance present STAM mechanisms with “capacity-on-demand” measures at operational level, paving the way to new airspace capacity management mechanism considering the constant increment on traffic demand through the pairwise adjacent-sector balancing mechanism to longer adjacent-sector chains.

Keywords: capacity on demand,virtual centre,dynamic airspace configuration,handover procedures,occupancy count,sector mobile area
A Scalable Platform for Next Generation Enzyme Drug Development (KUANGO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Kuano is an innovative UK TechBio company established in 2020, whose mission is to accelerate the discovery and development of novel drugs for cancer treatment, by harnessing the power of quantum simulation and artificial intelligence (AI). Our aim is to transform the drug discovery process, reduce the cost and time taken to deliver new drugs with novel modes of action to the clinic and improve the lives of millions of patients worldwide. We have demonstrated our current capabilities by advancing one drug design project to having disease relevant proof of concept with minimal funding in 9 months. We are now looking for EIC support to enable us to proceed with a hybrid approach - both running multiple internal drug design projects (for future out licensing) and supporting commercial partnerships that generate revenue. Funding at this stage would enable rapid commercialisation while retaining a business model targeting growth into a vertically integrated drug design company powered by our unique computational platform in the next 5 years. Kuano brings together unique expertise and combines drug discovery specialists with physicists, chemists and computer scientists committed to use cutting-edge technologies. Kuano consists of 4 co-founders and 8 full-time employees, supported by an experienced board of directors with proven scientific and business backgrounds. EIC support would provide us with both the funding and access to European networks necessary to supplement our team with additional drug development expertise (in the form of a CSO) and sector specific business development experience. Overall the funding would support team expansion to 25 people and the delivery of at least 3 drug design projects.

Keywords: drug design,oncology,ai,quantum,molecular modeling,techbio
Implementation of a novel in vitro methodology to assess pulmonary toxicological response mechanisms to high aspect ratio and complex materials (IMPACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: SIGNED

The main goal of this work is to assess the use of a novel in vitro methodology for lung toxicity testing of high aspect ratio nanomaterials (HARN). The candidate has substantial experience in exposure science and risk assessment, but her expertise regarding particle toxicity is currently relatively limited. The purpose of this application is to build a strong background in particle pulmonary toxicity, which will complement her expertise and consolidate her as a multidisciplinary researcher increasing her future career opportunities. Currently, to assess health risk due to exposure to different materials, the European regulation mainly relays on in vivo animal data. However, testing the multitude of new materials in vivo is challenging due to high costs, and ethical issues. In vitro tests are available, but still show limitations when compared to in vivo. HARN are particularly serious for human health, and one has been classified as carcinogenic. This is due to their size (small diameters that makes them respirable), needle-like shape, and biopersistency. In particular, this type of materials show specific issues for in vitro testing such as difficulty on preparing homogeneous and temporal stable dispersions, or the agglomeration of fibres in the suspension preventing single fibre exposures as opposed to what may occur in the lung. Therefore, new in vitro methods are needed in order to reduce in vivo testing and to overcome some of the mentioned limitations. The proposed work aims to fill this gap by testing a novel in vitro methodology that allows very high control of the particles morphology and dose administrated to lung cells at a thin liquid layer by aeroslosation and deposition into µ-dishes prior cell exposure. The results from this research will contribute to the current state of the art on fibre lung toxicity mechanisms, help on the implementation of a novel in vitro methodology for lung toxicity, and work towards the reduction of in vivo testing.

Keywords: high aspect ratio nano materials in vitro pulmonary toxicology occupational exposure indoor air particles
Solar cYcle prediCtion tool using sOlar internal oscillations (SYCOS) (SYCOS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Finland
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-02-01
End date: 2024-10-31
Duration (months): 21.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Short- and long-term prediction of solar activity and space weather are long-standing problems, affecting the society at a large scale: being able to issue a prediction earlier and more reliably will prevent economic losses for industries, space sector, and governments. During our ongoing ERC CoG project UniSDyn, we have numerically and observationally demonstrated the potential of a novel data product, the internal surface gravity oscillation mode, tracing the sub-surface magnetic field in the Sun, and here formulated methodologies to build prediction tools based on it both over short and long timescales. Earlier prediction methods have relied on magnetic fields on the solar surface or in the interplanetary space, while now we propose to use the solar internal oscillations as basis of the predictions - hence our ideas are novel and ground-braking. Innovation potential is augmented by the demonstrated capacity of the team to perform the demanding data analysis of the required data products for the proof-of-concept tools. Large innovation potential is also contained in new type of data service to be built: they augment the sustainability and re-usability of generic scientific data products, and enhance the renewal of science.
The Platformization of Music: Towards a Global Theory (PlatforMuse)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

How are streaming and social media platforms changing the working conditions and creative practices of music artists around the world? How can we better understand the transformative impact of “platformization” through the lens of music? Online platforms - from Amazon to YouTube – have been both celebrated and criticized. The COVID-19 pandemic has only further entrenched these platforms in our lives. PlatforMuse takes music as a medium through which to examine the impacts of platformization. It offers the first cross-national analysis of this transformation as understood by music artists. To date, most research into platformization is limited to case studies of particular platforms in particular countries. PlatforMuse provides a global perspective that is sensitive to the complexity of platformization. The three national contexts that make up this project – the Netherlands, South Korea, and Nigeria – represent three very different models and stages of platformization. PlatforMuse asks: How might the everyday experiences of music artists in diverse locations challenge some of the assumptions about how platformization proceeds, and in turn, help us to generate a truly global understanding of cultural production in the platform era? The PI has extensively researched music platformization in North America, Europe and Asia and is thus uniquely suited to realize the ambitious aims of this global project. The project is embedded in a multidisciplinary research network and an advisory board comprised of academics, industry experts and artists from the Netherlands, South Korea and Nigeria. Through innovative methods PlatforMuse promises to bridge and build upon diverse fields of study; including popular music studies, platform studies, media/cultural industries research, and ethnomusicology. The aim is to develop an integrative framework for theorizing the global platformization of music and to open up new research agendas for the study of culture in our ‘platform society’.

Keywords: cultural industries creative labour media studies platform studies cultural production music industries music streaming ethnomusicology
Clinical validation of the First Implantable Sensor System for Wireless detection of stent occlusion/ restenosis (StentGuard)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-10-01
End date: 2025-07-31
Duration (months): 34.0
Total project cost (EUR): 11306517.5
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Globally, over 237 million people suffer from peripheral artery disease (PAD), an abnormal narrowing of the arteries. The implantation of stents (spiral wire protheses) is the first-line therapy for PAD with ~ 3.5M stents implanted worldwide every year. Restenosis, the gradual reclogging of the blood vessel after stent implantation, is a major problem leading to high morbidity and mortality which occurs within 6 years after implantation in ~23 % of all cases and is often detected when it is too late. More frequent surveillance of PAD patients to avoid unnecessary amputations and death is an unmet clinical challenge. VesselSens is developing the StentGuard, a smart therapeutic monitoring device that enables rapid, low cost, early diagnosis of restenosis non-invasively and reliably. This device allows stent monitoring at high frequencies with low cost by non-specialist medical practitioners solving the problem of unchecked disease progression and saving the EU economy over €1bn/ year.

Keywords: biomedical,stent monitoring,restenosis,peripheral artery diseases,cardiovascular diseases
Expressing Value in Language (EVIL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499589.0
EU funding (EUR): 1499589.0
Participants: 1
Project status: SIGNED

Evaluative adjectives—words like ‘good’, ‘ugly’, ‘tasty’ and ‘elegant’—have interpretations that appear to depend on the context. If you describe a knife, a bear or an act of charity as ‘good’, you do not seem to be saying that it has some fixed property of goodness. Rather, the context in which you are speaking affects the interpretation of ‘good’. Evaluative adjectives are closely linked to concepts of central importance in philosophy, such as moral goodness, beauty, and value. Hence their apparent context-dependence has troubling consequences for many philosophical debates. For example, an act of charity could count as ‘good’ when we are talking about it in one context and as ‘not good’ when we are talking about it in another context, due to different interpretations of ‘good’. This startling conclusion is difficult to reconcile with most ethical theories. While philosophers and linguists have shown increasing interest in evaluative adjectives, a full analysis has remained out of reach for several reasons. First, philosophical and linguistic investigations often proceed in isolation from each other. Second, the scope of analyses can be overly specific, by virtue of focusing on a single case-study, or overly general, by focusing on features that supposedly unify all evaluative adjectives. Third, the predictions that emerge from different analyses are rarely subjected to empirical assessment. The project aims to give an account of the meaning of the word ‘good’ and other evaluative adjectives, along with the nature of goodness and other forms of value. It will be the first fully integrated analysis, by incorporating philosophical and linguistic perspectives, generalisations about evaluative adjectives and particular case-studies, along with empirical results. The novelty of the project lies in this integrative and interdisciplinary aspect. The results will resolve central and long-standing issues in both philosophy and linguistics.

Keywords: evaluative adjectives gradable adjectives value meta ethics philosophy experimental linguistics
New impetus to materials research - democratizing a frontier research tool (LynXes)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Hungary
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 2188500.0
EU funding (EUR): 1531950.0
Participants: 1
Project status: SIGNED

Our society is driven by constant technological progress, which crucially depends on advances in material science. The bottleneck of such advances is to see deeper into and understand better the molecular structures, which is limited by tools that are either i) accessible to many, but limited (and already fully exploited) in performance, or ii) are of high performance but restricted to only a few with large-scale infrastructures, and greatly limited by availability and cost. One of the most effective and prolific of materials analysis tools is high-energy-resolved X-rays capable of revealing high-definition molecular structure of new materials in working conditions. This is however only available at large, €1BN X-ray sources, with little and difficult-to-obtain machine time for R&D performers. This discourages most potential users and makes life hell for the few who try. Consequently most of the industrial R&D sector, which could benefit most from these tools, is not even aware of these opportunities. LynXes proposes to pack this technology into a self-sufficient tabletop solution, offering to disrupt the entire materials analysis sector and open up a whole new market worth around half a billion to a billion euros a year. We are convinced that this novel family of materials analysis methods could be a game changer in the research and development in many fields. The possible use cases range from developing novel materials for batteries or fuel cell systems, understanding and improving nuclear waste management, boost the performance of waste water treatment, etc. Our mission is to open new horizons for industrial and academic R&D by democratizing the access to high-energy-resolution X-ray spectroscopies (HERXS) technology. We believe that our technology will create a better world by boosting several key R&D and QA processes, especially in highly future-oriented sectors such as green chemistry, green energy, pharma, waste management, data storage, and so on. LynXes is poised to disrupt the market and bring advanced X-ray spectroscopy capabilities to a broader range of users, transforming R&D processes and contributing to the development of more sustainable technologies across the board.

Keywords: materials science novel materials energy green chemistry solar energy battery x ray spectroscopies large scale facility table top analytical device academia to market