Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Urban musics and musical practices in sixteenth-century Europe (URBANMUSICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-12-01
End date: 2016-11-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The urban musics and musical practices of sixteenth-century European cities have been studied only rather patchily in terms of geography and partially in terms of urban culture. Renaissance Italian cities, benefiting from a strong cultural historical tradition, have fared relatively well, while music in the urban context in France, Flanders, Germany and England has been considered in a steady trickle of studies over recent decades. The cities of the Iberian Peninsula, however, remain largely unexplored, a situation that derives in part from a peculiarly Spanish music historiographical trend that resulted in a series of studies focusing on cathedral musical life, with little or no consideration of a broader urban context. The preservation of the majority of Spanish sixteenth-century music sources in cathedral archives and the priest-musicologist tradition that persisted in Spain until the1980s were major factors in this trend, factors that also help to explain the still prevailing perception of Spanish musical culture as isolated from, and largely irrelevant to, the European musical mainstream. There is thus a compelling need to review this situation through the identification and analysis of the different musics (written and unwritten), musical practices (official and unofficial) and performative spaces of a city such as Barcelona. As a major Mediterranean port open to France and Italy and a hub for the book trade, Barcelona was clearly not isolated from the rest of Europe, and its urban culture can be analyzed in depth thanks to the wealth of documentary and musical material in the city’s archives. By developing methodologies drawn from cultural history, historical anthropology and ethnomusicology, by which music is considered in the context of urban culture and social interaction and communication from a totality of perspectives, this innovatory and interdisciplinary project will take a step further the mapping of European cultural history.

Keywords: s309 music and musicology - history of music,urban musics,urban performative space,performance practice,listening practice,musical dissemination,urban culture,unwritten musical traditions
Hybrid Nanophotonics for Enhanced Light Control (HYNANO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-08-01
End date: 2016-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Coupling of quantum emitters, and the exploitation of multi-photon quantum interference, is the next challenge for generation optical information technology and quantum computation. The aim of this proposal is to achieve long-range coupling of two or more quantum emitters, understanding the fundamental mechanisms of light transport, nano-optical emission control and resulting collective phenomena, such as super-radiance and lasing. A model system will be realised where the light originated from one quantum emitter is transported to the next one by a combination of photonic crystal waveguide and optical nano-antennas which together act as a bridge for light transport from the micrometer to nanometer scale.

Keywords: p108 optics and quantum optics,p212 nanophysics,c128 nanomaterials
Where do I belong? The effects of uncertainty-identity on acculturation outcomes for migrants in Germany (BELONGINGNESS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-04-01
End date: 2017-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

This research project will investigate multiple perspectives (migrant, host and intergenerational) on attitudes about integration, feelings of belongingness, group affiliation, and psychological and sociocultural adaptation of migrants. The proposed research project offers a new theoretical framework in which the bidirectional nature of the acculturation process is addressed. Acculturation theory and uncertainty-identity theory are integrated in order to investigate the possible consequences of uncertainty about oneself and belongingness. The main purpose is to understand (1) when and where conflicts and social tensions between host members and migrants as well as between generations arise, (2) why mal-adaptation of some proportions of migrants occur (e.g. identification with sub-groups to reduce uncertainty and oppose the host society), and (3) what intervening variables impact on positive outcomes (social cohesion, harmony). In three comprehensive studies, these key questions will be addressed. An advanced mixed-method approach will be employed to acknowledge different levels of analyses, namely the individual, regional and societal level. The proposed research will substantially contribute to the resolution of intercultural conflicts and the mechanism behind hostile attitudes. Moreover, it will be possible to explain the conflicts between hosts and migrants and offer ways of conflict resolution to build a more harmonious future. The findings will be very important and useful to equip host members and migrants as well as policy makers with the tools to work towards more positive outcomes and social cohesion.

Keywords: s106 globalization - migration - interethnic relations,intercultural psychology,acculturation,integration,identity
Theoretical simulation of vibrational spectroscopies based on the Raman effect (VIBRAMAN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2016-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The scientific objective of the VIBRAMAN project is to develop and apply computational strategies based on quantum chemical methods (mostly Density Functional Theory) to simulate electronic and vibrational spectroscopies. The project will focus of the theoretical description of photoabsorption, resonance Raman scattering, IR/UV sum-frequency generation and photoelectron spectroscopy. These processes will be investigated with original theoretical approaches developed by the applicant and will be employed to interpret experimental spectra in close collaboration with experimental developments. In particular, the results will provide understanding of the molecular properties and precious help in the design of new photocatalysts, sensitizers and nonlinear optical materials. The simulations will also provide fundamental assignments of spectroscopic data. An additional aim of the proposed project is to complete, maximize and enhance the scientific and management competencies of the applicant. Thus, the VIBRAMAN project is crucial for establishing the applicant as an independent researcher. It will support him in his effort to set up his own research group, to maintain lasting European collaborations and it will facilitate his integration in the Polish academic and scientific environment.

Keywords: c115 theoretical and computational chemistry,c103 spectroscopic and spectrometric techniques,c132 coordination chemistry,c105 surface science,p107 atomic - molecular physics
Development of new biofunctionalized materials for application in regenerative medicine (BIOMAT4BIOMED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-11-01
End date: 2015-10-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Biofunctionalization of materials for application in regenerative medicine constitutes a constantly expanding field that will introduce revolutionary changes in classical healthcare and drastically improve the quality of life of patients. In recent years, extensive research has focused on the development of new biomaterials with the ability to restore damaged parts of the body and enhance tissue regeneration. However, much of this challenging area of research remains to be explored. This is the case of orthopedic and dental implants, where a poor biointegration of implant materials is associated with limited long-term medical outcomes and implant failure. To overcome this issue, strong and stable biochemical and mechanical interaction between the implant surface and the surrounding bone tissue are required after the implant surgery. This research project aims to design, develop and investigate novel biofunctionalized metallic materials (low elastic modulus Ti alloys) for their application as biomedical devices for bone osseointegration and regeneration. Functional biomolecules with defined bioactive motifs to selectively enhance cell adhesion and improve biointegration, as well as with antibacterial properties, will be immobilized covalently on the metal surface by using organosilanes as crosslinker molecules. Biofunctionalized surfaces will be fully characterized for physical properties, chemical composition and biological activity. In vitro biological studies will include adhesion, proliferation and differentiation of mesenchymal stem cells. The biomaterials displaying the best biological profiles will be implanted in minipigs to investigate their osseointegration properties in vivo and their potential to be used in the clinics. This research project proposes a highly multidisciplinary approach combining high quality and excellence in the fields of Chemistry, Biochemistry and Material Science to overcome a major challenge in Medicine currently not addressed.

Keywords: biomedical engineering,biomaterial engineering,biomedical materials,tissue regeneration,regenerative medicine,peptide chemistry,medicinal chemistry,biomaterials
Studying the Structure and Dynamics of TCR nucleated Complexes at the single molecule level (PALM TCR COMPLEXES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-10-01
End date: 2016-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The cell transduces information across its plasma- membrane via the engagement of surface receptors and the subsequent recruitment of intracellular proteins to these receptors or to adapter proteins to form transient and heterogeneous signaling complexes. Multi- molecular signaling complexes can, in turn, be found in large microclusters or aggregates. Such signaling complexes and clusters have been shown to play a crucial role in T cell activation and thus, in the ability of the immune system to adequately respond to foreign pathogens. However, little is known about the detailed structure, content, and organization of signaling complexes due to severe limitations of current experimental techniques. I propose to develop and apply cutting-edge super-resolution microscopy techniques, biophysical models, and statistical methods to study mechanisms of cell activation by signaling complexes in single-molecule detail in intact cells. Previously, by imaging complexes downstream of the T cell receptor at the single- molecule level with photoactivated localization microscopy (PALM), I found that these complexes show functionally significant nano-scale organization at the plasma- membrane of activated cells. I hypothesize that signaling complexes have additional levels of dynamic organization that are crucial to the plurality of functions of these complexes in adequately activating T cells. Importantly, my developed techniques and expected results will be relevant to many other signaling systems and will greatly extend our understanding of the composition, structure, and formation of signaling complexes and mechanisms of cell activation in health and disease. Such knowledge will present novel opportunities for pharmacological intervention in diseases involving inadequate immune responses and in cancer.

Keywords: signal transduction,t cell activation,signaling complexes,single molecule,imaging,photoactivated localization microscopy,palm,super resolution,biophysics,immunosignalling
Understanding the regulation of physiological protein aggregation with age (AGGREGATINGPROTEOME)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2017-03-03
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Aging is a major risk factor for neurodegeneration, cancer and heart disease. Understanding what goes wrong with age, in particular how the proteome becomes dysfunctional may help to slow down or prevent these age-dependent diseases. Until recently, it was widely assumed that protein aggregation was mainly restricted to the extensive aggregation of a few hallmark proteins in diseases such as neurodegeneration and systemic amyloidosis. However, we have demonstrated using the model organism Caenorhabditis elegans that during aging in the absence of disease many more proteins are prone to aggregate with age. We will use this physiological protein aggregation as a novel readout to measure the health and age of the organism. Preventing this process will presumably “free up” the cellular systems and keep proteins functional even in an old organism. Overall, we seek to understand how protein homeostasis becomes deregulated with age leading to this widespread protein aggregation. We aim to achieve this by complementary strategies: We will establish a novel method to image protein aggregation dynamics and to determine how the intracellular quality-control systems regulate age-dependent aggregation. Using state-of-the art proteomics, we will distinguish which types of physiological aggregation are controlled by each of the main actors in the quality-control system. Finally, we will open new horizons by performing an RNA interference screen using a novel C. elegans model for extracellular protein aggregation. As many of the mechanisms which control aging in C. elegans are evolutionary conserved in mammals, we predict that our discoveries are relevant to higher organisms including humans. Our long-term goal is to identify novel targets which could be used to develop therapies to prevent diseases related to protein aggregation and to promote healthy aging.

Keywords: l511 neurological disorders,l203 proteomics,l404 ageing,cell biology,protein homeostasis,protein aggregation,caernorhabditis elegans
Structural response of photosynthetic apparatus to stress (SRPAS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Czechia
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-01-01
End date: 2016-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Photosynthesis is one of the most important biological processes on Earth. Photosystem I and Photosystem II are the key protein complexes in the photosynthetic or thylakoid membrane of chloroplasts for converting light energy. They mediate light-driven electron transport through the thylakoid membrane with help of additional light harvesting proteins. Both Photosystem I and II are organized into large supercomplexes with variable numbers of specifically attached membrane-bound light harvesting proteins. Under varying natural conditions plants have to regulate light harvesting to keep maximum efficiency of photosynthetic reactions under light limiting conditions and to prevent the photosynthetic apparatus from photooxidative damage under high light conditions. Acclimation and protective mechanisms involve considerable structural changes at the level of both individual photosynthetic proteins and the entire photosynthetic membrane, which are largely unexplored. Increasing our knowledge of stress induced structural changes of the photosynthetic apparatus is important for overall understanding of regulatory mechanisms of photosynthetic performance. Such information is of great importance to e.g. a booming field of artificial photosynthesis, which tries to mimic photosynthetic reactions at the laboratory conditions. The aim of proposed project is to monitor stress-induced structural changes (different light conditions, elevated temperature) of the plant photosynthetic apparatus at the level of individual supercomplexes of Photosystem I and Photosystem II and their associated antenna complexes using transmission electron microscopy and single particle image analysis. Another challenging aim of the research proposal is a visualization of stress-induced structural changes of (i) the overall organization and distribution of individual photosynthetic proteins within the thylakoid membrane and (ii) a folding of entire thylakoid membrane using cryo electron tomography.

Keywords: photosynthesis,membrane proteins,electron microscopy,cryo electron tomography,plant acclimation,plant photosynthetic membrane
Non-conventional target approach for drug discovery against neurodegenerative diseases: Nrf2 upregulation (NRF24NDDS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-11-01
End date: 2016-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

As a result of the aging population of the developed countries, neurodegenerative diseases (NDD) afflict an ever-increasing number of people. Alzheimer’s disease (AD) is the most prevalent NDD with more than 36 million people currently affected worldwide. Although AD has been studied for more than a hundred years, its “ultimate” trigger is not yet completely understood. Focus for over two decades on amyloid beta (Aβ) and tau protein, as targets to develop a neuroprotective medicine to delay Alzheimer’s disease (AD) progression, has so far failed. AD is developed as an extremely complex network of events, a fact that has led to the proposal of the “multifactorial hypothesis”. AD, to be defined, must be seen as interconnected processes, rather than independent pathways triggering the final consequences of the disease. In considering the genetic target-based approach, it should be taken into account that familial AD is less than 1%; thus, at least 99% of patients suffer a sporadic form of AD. It seems therefore reasonable to follow non-genetic approaches. For instance, the free radical theory implies progressive cell damage with age, leading to enhanced mitochondrial DNA mutations, futile mitochondrial Ca2+ cycling with excess ATP consumption, oxidative stress and ensuing mitochondrial dysfunction. Based on these observations, the objective in this proposal is the design of selective “multi-target drugs” able to modify two or more key steps in different AD related pathological pathways. By mixing several targets with tuneable properties in one molecule it will be possible to affect several pathways at once and therefore, affecting “redundancy” processes underlying AD. Non conventional selected target will be auto-defensive pathways (phase II gene expression) within the cell and the known targets that are known to be important in AD pathology. This multi-disciplinary approach will combine organic chemistry in order to develop novel structures with optimized properties.

Keywords: c141 organic chemistry,l503 neurochemistry and neuropharmacology,l703 pharmacology - toxicology - pharmacogenomics - drug therapy,l511 neurological disorders
Artificial Enzymes: Protein-Encapsulated Inorganic Nanoparticles (ARTEN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Enzymatic catalysis is one of the key processes for biochemical conversion in nature and of utmost importance for any form of life. The base for this kind of conversion is the enzyme itself, which is a very specialized protein targeting another molecule, peptide, or protein in a very specific way to convert it into a product with a minimum of activation energy. The latter point is very critical as it allows biochemical reactions at physiological conditions. This specialization to physiological conditions is, although beneficial for natural processes, very often a drawback for technological processes. Enzymes, being proteins, in most cases cannot resist serious deviations in temperature or pH values and degrade. This operating window of the enzymes limits their flexibility for ex vivo application in technical synthesis, food processing, etc., seriously. Inorganic nanoparticles (NPs) are considered to be a very promising alternative to enzymes as they might increase the operating window for the catalytic reaction. The research direction resembles a sort of molecular biomimetics, since inorganic phases are supposed to mimic biomaterials (enzymes) in their function. Few examples of enzyme-mimicking inorganic nanoparticles have been investigated until now, with the most prominent particles consisting of Fe3O4, CeO2, or Pt. This project aims to go far beyond the current state of the art. With protein-encapsulated inorganic nanoparticles the goal is one the one hand to gain knowledge on enzyme-analogue catalytic reactions with various inorganics and on the other hand to approach application fields of such composite inorganic enzymes by controlled modification of the protein shell they are embedded in.

Keywords: c102 nanochemistry,c128 nanomaterials,c113 physical chemistry of biological systems,c136 homogeneous and heterogeneous catalysis