Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Computationally and experimentallY BioEngineeRing the next generation of Growing HEARTs (G-CYBERHEART)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1497351.25
EU funding (EUR): 1497351.0
Participants: 1
Project status: SIGNED

Congenital Heart Disease (CHD) results when the heart abnormally develops before birth. With diminished cardiac function, the heart fails to supply the required oxygenated blood to the body, causing a cascade of failures at different scales that prevent the newborn from growing normally. Even with improved surgical and medical treatments, CHD remains a lifelong risk factor for many diseases. An emerging application in cardiac tissue engineering is the 3D bioprinting of human hearts, or their parts, for clinical transplantation, with CHD representing a potential therapeutic target. Whereas the fabrication of bioartificial hearts is currently feasible, there remain significant scientific and technological challenges that yet need to be overcome. The development of novel experimental approaches is fundamental. At the same time, there is a pressing need for complementary computational methods to efficiently assist in the design of biophysically feasible and printable hearts, which must necessarily grow with the CHD patient's body while adapting to lifelong changes in hemodynamic conditions. In this project, therefore, I will develop a highly novel and interrelated experimental and computational approach for reproducing and predicting growing conditions of bioengineered hearts. The ambitious experimental design will enhance the maturation of cardiac muscle and biomechanical function of bioprinted ventricles in dynamic bioreactors. The highly-coupled multi-physics computational platform will describe these complex processes under multiple stimulated conditions to, ultimately, predict the critical adaptation and evolution of bioengineered ventricles potentially implanted in CHD patients. Therefore, by integrating ground-breaking methods within an extremely complex scenario, G-CYBERHEART will cross boundaries to drive advances in regenerative medicine and tissue engineering that will help accelerate the development of the bioengineered heart of the future.

Keywords: computational modelling,cardiac mechanics,growth and remodelling,tissue engineering,3d bioprinting
Employing the natural genetic variation to improve nutritional properties and stress tolerance in vegetable crops (NatGenCrop)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Bulgaria
Call: ERA Chairs (HORIZON-WIDERA-2022-TALENTS-01, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2432500.0
EU funding (EUR): 2432500.0
Participants: 1
Project status: SIGNED

Yield and nutritional properties of vegetable crops are affected by unfavorable environmental conditions, such as drought, salinity, extreme temperatures, and pollutants. This project aims at improving stress tolerance of major vegetable crops and design new strategies for maintaining higher yields and food quality even during unfavorable weather conditions. One of the major research directions is exploring the wide genetic and phenotypic variations of fleshy (tomato, pepper) and leafy (lettuce) vegetables to improve agronomical traits under abiotic stresses (e.g. drought, salinity, and extreme temperatures). We will employ a suite of genetics and genomics approaches, such as GWAS in combination with QTL, to identify genes contributing to high yield and stress tolerance. In another research direction, we will characterize the fruit metabolic compositions in terms of flavor and healthy related compounds to assess the impact of abiotic stress on fruit quality. A wide range of plant phenotypic, and metabolic traits will be evaluated, followed by transcriptomic profiling in two genome-wide association (GWAS) panels and two backcrossed inbred lines (BILs) populations for both tomato and pepper. The identified genes will be subsequently validated by CRISPR-Cas9 editing technologies and field trials. To implement this ambitious work program, a new research department “Crop Quantitative Genetics” will be established in the Center of Plant Systems Biology and Biotechnology (CPSBB) in Plovdiv. The new research department will scale up the applied research on vegetable breeding in CPSBB and the region. Furthermore, the new CPSBB department will link with Bulgarian and international research organizations, companies, and farmer associations in the field of crop science, creating an ecosystem network that is highly attractive to talented researchers and brings the innovations to end users for the benefit of the society.
SOMO-HOMO Inversion For chiral open-shell pi-conjUgated systeMs (SHIFUMI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1744065.0
EU funding (EUR): 1744065.0
Participants: 1
Project status: SIGNED

Organic Materials are of strong interest for increasing the performances of modern electronic devices (OLED, photovoltaics, transistor) while reducing their overall cost in comparison to classically used rare and precious metals and semi-conductors. In this domain, chiral pi-conjugated molecules have recently opened new directions, due to their specific interaction with circularly polarized (CP) light, and their unique electron spin filtering ability, known as Chiral Induced Spin Selectivity (CISS) effect. Related to the molecular magnetic moment, these properties have been only investigated for closed-shell chiral systems with weak magnetic property, which currently limits the potential of chiral molecules as spin-filter organic materials. Designing open-shell chiral organic materials with high magnetic property, such as in organic high-spin diradicals, appears therefore a promising direction for the future breakthrough of optoelectronics by controlling both electronic and spin properties. However, synthetizing organic chiral diradicals remains a considerable scientific challengedue to their high chemical reactivity and the difficult control of their magnetic properties. Accordingly, the molecular combination of chirality and diradical state remains relatively unexplored, fundamentally poorly understood, and unknown for chiral photonic and magnetic applications. In this project, I will design unprecedented stable organic chiral di- and polyradicals where the singly occupied molecular orbitals (SOMO) will be energetically below the HOMO level. This energetic SOMO-HOMO Inversion (SHI) will represent a disruptive appraoch to stabilize chiral polyradical and to design chiral high-spin systems, a major breakthrough in Material Science. Such innovative union of spin and chirality will give me the opportunity to develop CP-OLED with 100% of theoretical efficiency and unprecedented near infrared CP-light-responsive spin-filtering devices for data processing and storage.

Keywords: pi conjugated systems,chirality,organic radical,somo homo inversion
Poisson cohomology and linearization for simple Lie algebras (PCHL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Given a geometric structure, can we find local coordinates such that the structure has a particular nice expression? That is one of the most fundamental questions for any geometric structure, that of a local normal form. In Poisson geometry, this question is directly related to the study of Lie algebras, as any Lie algebra is equivalent to a linear Poisson structure on its dual. Given a Poisson structure with a singularity, can we locally identify the Poisson structure always with its linear (first order) version around the singularity? This question was first asked by Weinstein his seminal work on Poisson manifolds in 1983. However, even for (semi)simple Lie algebras, this question has not been completely resolved, despite several results. In particular, it is not know for (semi)simple Lie algebra of real rank one with semisimple compact part. In this project we aim to resolve the problem for all remaining simple Lie algebras, taking an important step towards a complete answer. In the lowest dimensional case, that of so(3,1), an affirmative, positive answer has been provided by myself in my PhD thesis. This is the first non-compact example with a known positive answer. The general strategy is the following: 1) Show that the cohomology group controlling the deformation problem vanishes and find sufficiently nice cochain homotopies 2) Apply a Nash-Moser type inverse function theorem to establish linearization Generalizing the ideas of the proof to all simple Lie algebras will bring together techniques from foliation theory, symplectic geometry, homological algebra. Additionally it will require developing and applying new techniques in algebraic geometry, representation theory and functional analysis, specifically adapted to the Lie algebras under consideration and their stratification by (co)adjoint orbits. As such, the result will be highly influential and interesting for several areas of Mathematics.

Keywords: poisson geometry,representation theory for simple lie algebras
Gas flows in and out of galaxies: solving the cosmic baryon cycle (FLOWS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 2499424.0
EU funding (EUR): 2499424.0
Participants: 1
Project status: SIGNED

Galaxy formation is driven by the flows of gas in and out of galaxies, which remain poorly understood. Galaxies grow and fuel their star formation through the accretion of new gas, while stellar and AGN activities eject copious amount of gas into the environment. The physics of and interplay between these phenomena (cosmic baryon cycle) are extremely complex, with the consequence that our current understanding of how and when gas flows take place and their impact on the life-cycle of galaxies is still patchy. Hence, the FLOWS ERC project is designed to precisely determine the properties of gas flows in and out of galaxies across cosmic time and explain their role in galaxy formation and evolution. With FLOWS, we will conclusively determine how gas accretion from the environment takes place and how it changes with time. We will accurately measure the properties of galactic winds and fountains and establish their role in regulating the gas content of galaxies. We will build the next generation of predictive galaxy evolution models that will include, for the first time, fully constrained gas flows. FLOWS will achieve these ambitious goals thanks to a unique and powerful combination of innovative data analysis and theoretical investigations. My team will study gas flows in and around galaxies using the full range of state-of-the-art data coming from ALMA, the SKA pathfinders, the VLT, the HST and JWST. Most importantly, we will design new analysis techniques, including the first 3D code to model galactic winds directly in datacubes. Ground-breaking theoretical methods will allow us to combine the benefits of large-scale models with high-resolution magneto-hydrodynamical simulations. This multifaceted approach, which is the key to crack the baryon cycle problem, derives its strength from the diverse research lines that I have pursued in the past years, which puts me in a unique position worldwide to the make the major leap forward that FLOWS promises to achieve.
Explaining Individual Lifespan Change (EILisCh)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Iceland
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 1499000.0
EU funding (EUR): 1499000.0
Participants: 1
Project status: SIGNED

The EILisCh project will focus on linguistic variation and change in Icelandic syntax and it will be the most ambitious attempt so far to model, understand, and explain Individual Lifespan Change in linguistic behavior, drawing on recent advances in sociolinguistics, quantitative syntactic theory, clinicial linguistics, as well as resources recently made available by Language Technology. The project will harness these ingredients and the experience of the PI and the infrastructure present in his Language and Technology lab in order to facilitate a new kind of a large scale project that will yield substantial progress towards important empirical, theoretical, and methodological goals, as well as benefits for society. I will track hundreds of Members of Parliament via their speeches over their entire political career and interview dozens of current and former MPs to establish an even deeper profile of how they use language. Carrying this research out in Iceland is important because of the unusually easy access that researchers have to public figures in this small language community. The kind of precise modelling that I describe in this proposal is only possible in a project that builds on substantial pre-existing Language Resources and takes place in a setting where extensive knowledge of the linguistic data and the required technological tools is present. My Language and Technology lab at the University of Iceland is the right place to do this and the experience I have gathered in several previous projects will be essential for my team’s success. However, the scale of this enterprise is beyond the means of national funding agencies in Iceland; thus I turn to the ERC, so that together we can redefine the state of the art in the study of Individual Lifespan Change.

Keywords: linguistic lifespan change,sociolinguistics,language variation and change,quantitative syntax,language technology,icelandic language
RNA topology of test samples and single extracellular vesicles: how cells package RNA messages to communicate (RNA-top) (RNA-top)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,Hungary
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-01
End date: 2025-07-31
Duration (months): 30.0
Total project cost (EUR): 234530.4
EU funding (EUR): 234530.4
Participants: 4
Project status: CLOSED

In “RNA-top”, I will investigate the precise location(s) and quantity of RNA associated with extracellular vesicles (e.g. EV-RNA topology). To achieve this goal, I will set-up innovative liposome-based synthetic vesicle models (herafter referred to as test samples), resembling EVs, with a known RNA topology. I will use these test samples to create workflows for super resolution microscopy (SRM) and spectral flow cytometry (sFCM) to study RNA topology. These workflows will be extrapolated to EV samples, to define EV-RNA topology of single EVs for the first time. The research will be conducted in the Amsterdam UMC under the supervision of Dr. Rienk Nieuwland. Nieuwland and his team have the knowledge, experience and technical infrastructure to perform SRM and sFCM to study EVs. Therefore, RNA-top will allow me to deepen my knowledge on EVs and gain skills to perform SRM and sFCM. Conversely, I will bring my expertise in liquid biopsies and RNA, obtained during my PhD in Pangaea Oncology in Barcelona (H2020-MSCA-ITN). I will carry out a secondment in the lab of Dr. Zoltán Varga (Research Center for Natural Sciences in Budapest), an expert in the field of creating test samples, to get hands-on training. At the end of the project, I will join Exometry, supervised by Dr. Edwin van der Pol (CSO), for a 6-month non-academic placement to (1) develop an analysis software to process RNA topology data and (2) gain commercialization skills. The unique interdisciplinary and inter-sectoral combination of the participating organizations and myself, unites all the expertise and infrastructure required to reach the objectives of RNA-top.

Keywords: extracellular vesicles,extracellular vesicle rna,rna topology,liposome based test samples,liquid biopsy biomarker,super resolution microscopy,spectral flow cytometry
Simulated Majorana states (SiMS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Sweden,Netherlands
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2024-07-31
Duration (months): 66.0
Total project cost (EUR): 1997513.0
EU funding (EUR): 1926263.0
Participants: 2
Project status: SIGNED

Quantum computation using topologically protected Majorana bound states is a promising direction towards scalable quantum architectures due to their inherent noise immunity provided by the nonlocal storage of quantum information. Thus far, Majorana states have mostly been investigated in superconductor-semiconductor heterostructures which rely on induced superconductivity in a quasi-one-dimensional conductor. However, despite tremendous efforts in material development, these devices are still limited by uncontrolled local fluctuations due to disorder and it is unclear if future developments will solve these problems. Furthermore, disorder may even mimic the transport signatures of topological ordering, hindering an unambiguous identification of the Majorana states. Here I propose a way to overcome these limitations: I will work towards the direct quantum simulation of the one dimensional topological superconductor with Majorana bound states. I will use chains of semiconductor quantum dots, which is an emerging platform to simulate exotic many-body electron states. Building on this platform, I will be able to demonstrate for the first time the emergence of coherent, non-local superconducting states bound to the entire device similarly to the Kitaev chain model of topological superconductivity. To demonstrate quantum coherence of the chain, we will build the first Andreev molecule quantum bit, which, while not topologically protected, will already combine advantages of superconducting and semiconductor qubits. Going one step further, we will investigate the simulated Kitaev chain. Upon establishing the presence of the simulated Majorana states, we will work towards a simple braiding protocol to demonstrate the non-Abelian nature of the edge modes. This research direction, combining the scalability of semiconductor structures and the topological protection of Majorana states, will open new avenues towards universal quantum computation.

Keywords: superconductivity,quantum simulation,quantum dot,semiconductors,majorana states,topological states of matter
Next generation short-sea ship dual-fuel engine and propulsion retrofit technologies (SeaTech)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Countries involved: Estonia,Norway,Greece,Norway,Finland,Netherlands,Netherlands,United Kingdom
Call: Retrofit Solutions and Next Generation Propulsion for Waterborne Transport (H2020-MG-2019-TwoStages, 2019)
Start date: 2020-06-01
End date: 2023-11-30
Duration (months): 42.0
Total project cost (EUR): 6478472.25
EU funding (EUR): 4999243.0
Participants: 8
Project status: SIGNED

The SeaTech consortium is proposing to develop two symbiotic ship engine and propulsion innovations, that when combined, lead to an increase of 30% in fuel efficiency and radical emission reductions of 99% for NOx, 99% for SOx, 46% for CO2 and 94% for particulate matter. The innovations will be characterized by high retrofitability, maintainability and offer ship owners a return-on-investment of 400% due to fuel and operational cost savings. The proposed renewable-energy-based propulsion innovation is the bio-mimetic dynamic wing mounted at the ship bow to augment ship propulsion in moderate and higher sea states, capturing wave energy, producing extra thrust and damping ship motions. The proposed power generation innovation is based on the idea of achieving ultra-high energy conversion efficiency by precisely controlling the auto-ignition of the fuel mixture at every operating point of the engine for achieving radically reduced emissions. The ultimate objective of the project is to upscale both technologies, demonstrate them in relevant environment and finally model the expected complementarities and synergy effects of deploying both innovations on a short-sea vessel scenario by extrapolating demonstration data with the help of a bespoke Advanced Data Analytics Framework. The project partners envisage to commercialize both symbiotic innovations in the European and Asian short-sea market by 2025, followed by the adjacent deep-sea market. Assuming only 10% of EU short-sea vessels would be retrofitted with SeaTech, this would result in CO2 savings of 32.5 million tons annually, which equals the emissions of 200.000 passenger cars/year. Further impact includes savings of EUR 85.2 billion in health and climate change damages due to lower emissions, the creation of +100 jobs at the project partners with a cumulative net profit of EUR 820 million in the first 5 years post-commercialisation, and the indirect creation of 250 new jobs in the EU shipyard industry.

Keywords: retrofit,flapping wing,dual fuel engines