Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
It’s not my fault I am aggressive, they picked on me: How early peer relations affect DNA methylation and neurocognitive development in children (socio-bio interplay)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands,Netherlands
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2020-12-31
Duration (months): 66.0
Total project cost (EUR): 1962679.0
EU funding (EUR): 1389026.5
Participants: 2
Project status: CLOSED

Think about the day you took your child to kindergarten for the first time. You were worried. Worried about the social experiences of your child. Would peers like your child, or would it get bullied, or rejected by classmates? Many children have positive social school experiences, but 10-15% of children become rejected, victim of bullying, have few friends and have poor relations with teachers. Such experiences have been linked to aggression development, but we poorly understand how. I hypothesize that adverse social experiences in kindergarten and elementary school affect the neurobiology of children. Specifically, I aim to study how adverse social experiences (1) affect DNA methylation of genes implicated with stress regulation, and (2) affect neurocognitive functions underlying self-regulation, thereby increasing aggression. I will use a multidisciplinary approach to comprehensively study these hypotheses by using the strengths of twin-, observational and experimental studies. I will first study the impact of bully-victimization on children’s methylation of DNA and neurocognitive function development in monozygotic twins differing in bully-victimization, to test whether bully-victimization affects the neurobiology above and beyond possible genetic effects. I will then focuses on cross-time influences of multiple social experiences on DNA methylation and neurocognitive functions. Adverse versus protective effects of peer- and teacher-relations on DNA methylation and neurocognitive functions will be studied to explore possible cascading, accentuation, and buffering effects. Further, sex differences will be addressed. In the final set of (lab-experimental) studies I aim to unravel how DNA methylation of genes implicated with stress system responses, and altered neurocognitive functions lead to aggression by studying differences between chronically rejected and stable non-rejected children in stress-, and self-regulation following a social exclusion experience.
LIfetime measurements with Solid Active targets (LISA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany,Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1996250.0
EU funding (EUR): 1996250.0
Participants: 2
Project status: SIGNED

The coexistence of single-particle and collective degrees of freedom in atomic nuclei gives rise to various exotic phenomena. In nuclei with very asymmetric proton-to-neutron ratios, the strong nuclear interaction drives shell evolution which alters the orbital spacing, and in some cases even the ordering present in stable nuclei. In the absence of large gaps between orbitals, nuclei can take on non-spherical shapes and their excitations proceed through coherent and collective motion of many nucleons. Where and how collectivity emerges from the single-particle dynamics of protons and neutrons is an open question in nuclear structure physics that will be addressed with LISA in a unique way. The aim of the LISA (LIfetime measurements with Solid Active targets) project is to develop a novel method for lifetime measurements in atomic nuclei. Lifetimes probe the collectivity of a nucleus through its electromagnetic transition properties. The experimental approach is based on active solid targets and will dramatically enhance the scope of measurements of excited-state lifetimes and thus transition probabilities achievable in exotic nuclei. Coupled to state-of-the-art gamma-ray tracking detectors such as AGATA, this novel instrument will overcome the present challenges of lifetimes measurements with low-intensity beams of unstable nuclei. LISA will exploit the unique capabilities of FAIR, the future European fragmentation facility set to deliver the most exotic and highest intensity radioactive ion beams. LISA will greatly expand the physics program for nuclear structure studies at FAIR. Through the measurements made possible by LISA, our understanding of key aspects of single-particle and collective structures and their interplay will become much more developed. The results will have significant impact on the theoretical descriptions and modeling of atomic nuclei making their predictions more reliable.

Keywords: nuclear structure,exotic nuclei,radioactive beams,electromagnetic transitions,single particle,collective excitation
Anchialine caves to understand evolutionary processes (ANCAVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-11-01
End date: 2019-10-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The goal of this project is to use the animal communities inhabiting anchialine environments as a model to investigate evolutionary patterns and processes in island-like marine habitats. Anchialine environments represent world-wide distributed land-locked water bodies with marine origin. They are comparable to islands for terrestrial habitats as they encompass young, discrete habitats with comparable ecological conditions to the sea, thus providing independent replicates of comparable evolutionary processes. All anchialine habitats previously investigated harbor high endemism, disharmonic communities, species with unique set of troglomorphic features, and old animal lineages interpreted as living fossils. In the four research parts of this project, we will test each of these observations and the processes related to them by analyzing large data sets with both macroecological and phylogenetic methods and a broad theoretical perspective from the field of evolutionary ecology, comparative evolution and island biogeography. This will facilitate to link the ecological and evolutionary processes observed in these habitats (easy to isolate and test due to the discrete and young nature of anchialine habitats) with those affecting oceanic ecosystems, providing a tool for a deeper understanding of the marine biota. Whereas similar approaches are well characterized in terrestrial environments (e.g. island), they are missing in the ocean, obscuring our understanding of the processes occurring there.
More Automated Factories (MAF)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Spain
Call: Auto testing technologies and more automated factories for Aircraft validation test process (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 400000.0
EU funding (EUR): 400000.0
Participants: 2
Project status: CLOSED

The objective of the project is to develop new ways to implement quality validation of aircraft products in a more efficient manner, reducing non-recurring costs, reducing the need of man-hours and the involvement of manipulation by an human operator, reducing lead times and flexibility of the processes, through minimization of test means dependency trying to maximize the usage of the current Aircraft computers, and implementing new concepts for the automation of quality and validation tests on the aircraft, through artificial vision and robotic collaboration.

Keywords: the objective of this proposal is to explore further possibilities to implement quality validation of aircraft products in a more efficient manner
Algorithms and multiplex assays for integrated serological surveillance of malaria and neglected tropical diseases (MultiSeroSurv)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France,Senegal
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-01-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1174500.0
Participants: 2
Project status: SIGNED

Malaria and neglected tropical diseases (NTDs) such as lymphatic filariasis, onchocerciasis, trachoma and schistosomiasis affect almost 2 billion people every year. Coordinated targeting of these diseases will aid future control and elimination campaigns, but this will require integrated surveillance strategies. Malaria surveillance is routinely implemented through cross-sectional surveys where blood samples are tested for parasites. A major barrier to routine NTD surveillance is the range of samples required for parasite diagnosis: stool, urine, blood, eye swabs and skin snips. Instead of direct detection of parasites, there is an opportunity to implement serological surveillance by measuring antibodies to multiple pathogens in blood samples collected for malaria surveillance. This proposal has four aims: (i) Characterise the sero-epidemiology of malaria and NTDs in longitudinal cohort studies in Senegal, Ethiopia, Cambodia and Papua New Guinea; (ii) Measure antibodies to 34 antigens from 12 pathogens from single blood samples; (iii) Model antibody kinetics and validate the use of serology for detecting infections; and (iv) Demonstrate how a population’s concurrent and past exposure to multiple parasites can be estimated by analysing multiplex data from cross-sectional surveys. These aims will be achieved through innovative epidemiological studies, new technologies, and especially developed analytic methods, including: (1) utilisation of multiplex bead-based Luminex assays; (2) mixed-effects models in a Bayesian framework with data augmentation to identify serologically suspected infections, with validation against confirmed infections; and (3) statistical algorithms for reconstructing long-term and recent transmission trends. This interdisciplinary project will undertake fundamental research in analytic methods for processing complex multiplex data and converting it to the actionable information needed for integrated serological surveillance of malaria and NTDs.

Keywords: malaria,neglected tropical diseases,serology,statistical modelling,mathematical modelling,surveillance,trachoma,onchocerciasis,lymphatic filariasis,schistosomiasis
Single-molecule visualization of individual multi-drug efflux pump activity in living bacteria with nanophotonic biochips (Illuminate-AMR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2024-05-22
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

Nanophotonic chips hold great promise in imaging by providing molecular-level insights into biological processes occurring in live cells. By tuning their design, it becomes possible to selectively modify light at their surface such that they can be used to study the properties of biomolecules and cells at high resolution near the interface. On-chip decoupling of the excitation and emission light at multiple wavelengths is however a challenge in optical microscopy. The aim of this project is to substantially improve imaging of membrane processes in cells with biochips and then study population dynamics of multi-drug efflux pump activity in antimicrobial resistant bacteria by widefield nanoscopy. The objectives are (i) to develop and test a new nanophotonic biochip with which to visualize and track membrane bound proteins and their activity in single living bacterial cells under common light microscopes; (ii) to develop a direct assay for imaging the presence and activity of multi-drug efflux pumps in bacterial membranes at the single-cell level; and (iii) to implement and compare the biochip platform with modern single-molecule approaches. This imaging platform is based on encoding several precise periodicities to the surface of the biochip in order to diffraction-couple the light to traveling surface waves at multiple resonant wavelengths. This biochip will be a superior alternative to expensive TIRF microscopes that have a limited field of view, and will practically offer an improved evenness of illumination, smaller footprint, and a more accurate knowledge of penetration depth of the evanescent field. The biochip will be used to elucidate how phenotypic heterogeneity in multi-drug efflux pump activity contributes to bacterial survival and thus help improve current antibiotic treatment schemes. Such technology will result in immediate benefits for integrative cellular and molecular biology research communities, and thus has a strong potential for commercialization.

Keywords: single cell microbiology,multi drug efflux,phenotypic heterogeneity,antimicrobial resistance
Enhancing the regeneration of bone defects in elderly: Rejuvenation of bone microenvironment (RejuvenateBone)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-10
End date: 2018-06-10
Duration (months): 24.0
Total project cost (EUR): 178156.8
EU funding (EUR): 178156.8
Participants: 1
Project status: CLOSED

Bone defects resulting from trauma, tumor resection and bone diseases represent one of the most pressing health problems in the aging European population. Current treatments of bone defects depend on a functional population of bone-forming (osteogenic cells) to mediate the process of bone regeneration. However during aging, the bone formation capacity decreases as a result of multiple interacting cell-intrinsic and cell-extrinsic mechanisms and the success of treatments in aged patients is in most cases limited. The aim of our project is to develop a new multidisciplinary approach to enhance the regeneration of bone defects in elderly, based on recent advances in cellular reprogramming and tissue engineering. We propose to investigate the extrinsic microenvironment components synthesized by young, embryonic-like osteogenic cells derived from human induced pluripotent stem cells, and test their potential to enhance the function of endogenous bone and vascular cells. We will focus our studies on the patients unable to benefit from the current therapies, due to advanced age and/or systemic conditions limiting their bone formation capacity. We will develop allogeneic, off-the-shelf bone tissue substitutes with the capacity to enhance the function of endogenous cell populations, and evaluate their safety and bone healing potential in preclinical models of bone repair. We hypothesize that ostegenic cells derived from reprogrammed adult/aged somatic cells can synthesize a “rejuvenated”, embryonic-like bone microenvironment with high regenerative capacity and enhance the bone healing processes mediated by aged endogenous cell populations. Our studies will provide new understanding of extrinsic mechanisms governing bone cell biology during aging and open new therapeutic possibilities for the aged patients currently lacking successful outcomes. The developed bone substitutes will also provide a valuable new model for basic biology studies and translational research.
RNA functions in parasite-host communication in the gut (RNACOM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1993771.0
EU funding (EUR): 1993771.0
Participants: 1
Project status: SIGNED

Cross-species communication is required for proper functioning of the mammalian gut, where different organisms share resources, coordinate digestion and maintain homeostasis. In many animals, parasitic worms (helminths) are part of this ecosystem, where they communicate through the release of bio-active molecules that promote immunological tolerance and modulate gut functions. Mechanisms of cross-species communication are still not well understood and my lab discovered that ribonucleic acids (RNA) are one of the products helminths release to directly influence host cells. The overall goal of RNACOM is to determine how gastrointestinal parasites use this novel form of RNA communication to regulate the gut epithelium and to develop strategies to block the communication mechanism during infection. We have recently discovered a specific Argonaute protein that gastrointestinal nematodes use to transmit parasite RNAs to mouse cells. We will target this protein to identify parasite-host RNA-RNA interactions that occur during chronic infection (Aim 1). We will then determine the specificity and function of parasite RNA transmission to mouse cells in the epithelium using model organoids and in vivo imaging (Aim 2) and will determine the mechanism of action of parasite RNAs in host gene suppression using synthetic and recombinant strategies (Aim 3). Finally we use genetic tools in the mouse model to determine the function of cross-species RNA-RNA interactions during infection, while testing new strategies to block RNA transmission by the parasite (Aim 4). RNACOM will bring key quantitative and molecular understanding to the processes by which RNA from one species can influence another, advancing a frontier area in RNA biology while testing new strategies of parasite control. In parallel RNACOM develops a unique platform for identifying new gene networks that underpin intestinal cell functions and gut health.

Keywords: helminth,host pathogen,extracellular vesicle,rna interference,extracellular rna
Evolving Attitudes toward Single Motherhood in the UK and Russia (SingleMother)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Single motherhood has become a widespread phenomenon within contemporary societies, part of an ongoing revolution in family life. In order to address the outdated and thoughtless language being used to describe single mothers and their children, I will scrutinize the emergence and development of 21st century European cultural attitudes toward single motherhood using desk-based methods. To reconstruct its evolvement since the beginning of the century, this study proposes an innovative multidisciplinary approach, which combines comparative analysis of the UK’s and Russia’s policies toward single mothers with content and multiple approaches to text analysis of non-fiction, children’s and young adult fiction, social semiotics and multimodal discourse analysis of children’s illustrated literature. The overall aim of the proposed research is to advance my career through the completion of the present project, which examines the development and current stage of the cultural attitudes and policies directed toward single motherhood in two politically different countries. This aim is reflected through three primary objectives: to investigate contemporary European policy on single motherhood with focus on the UK and Russia, with attention to public attitudes toward the variation (unwed mothers, widows, divorced mothers, single mothers by choice) within single mothers as a social group; to examine the gendered British and Russian cultural ideologies since the beginning of the century up to the present and expressed through non-fiction and children’s and young adult literature and centered around social and cultural facets: abortion, virginity, affairs with men, pedagogical strategies, bad habits, beauty and clothes, professional career and education, and (re)marriage; to examine how this coding system was adapted to rules and grammar of the visual and, therefore, represented in children’s illustrated texts.

Keywords: women s studies,single motherhood studies