Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The role of the antiviral RNA interference response in the C. elegans–Orsay virus pathosystem (VirAgo)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Canada
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 223428.0
EU funding (EUR): 223428.0
Participants: 2
Project status: SIGNED

Viruses infect all known living organisms, and the RNA interference (RNAi) response is one of the main defense mechanisms cells use against viruses. Even though we have a general understanding of the players involved in the antiviral RNAi response, with some systems more characterized than others, we still lack mechanistic details about the process. For example, in the C. elegans-Orsay virus pathosystem, loss of certain RNAi proteins can be advantageous for the virus, but it is still unclear whether this is because the virus highjacks the RNAi machinery for its own advantage or because the absence of certain RNAi proteins frees up resources which can then be used for antiviral defense. Moreover, preliminary results show that there are distinct viral RNAi silencing complexes, but the composition and function of these complexes is still unknown. Finally, the RNAi response seems to prevent multicellular viral colonization through yet unidentified mechanisms. In this proposal we aim to address these three open questions to improve our understanding of the role of RNAi in the defense response to a viral infection. We will perform a comprehensive analysis of the antiviral RNAi pathway and the Argonautes – the main effectors of the RNAi pathway –, their interactors and targets upon Orsay virus infection. We will use a multidisciplinary approach, combining in-depth analyses from virology, cell biology, genetics, genomics and developmental biology. This will be possible due to the collaboration between the researcher and the laboratories of Prof. Elena, the coordinator and virology expert, and Prof. Claycomb, the outgoing phase host and cell biology and small RNA regulation expert. The expertise the researcher will obtain goes beyond the research in either laboratory and will help her crystalize the unique research profile necessary to take her career to the next level of independence.

Keywords: rnai,antiviral response,orsay virus,c elegans
A microRNA-regulated cell death-inducing gene therapy for T-cell Acute Lymphoblastic Leukemia (miRToTALL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Portugal
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy. Although outcome has improved throughout the years with the use of combined chemotherapy, the aggressive regimens required for treatment efficacy often lead to significant short- and long-term side effects. Moreover, a significant fraction of T-ALL patients relapse, which have extremely poor prognosis. The current project aligns with the core goal of our ERC Consolidator Grant IL7sigNETure (CoG-648455) to generate new targeted therapies for improved treatment of T-ALL, by aiming to develop a gene therapy cell death-inducing system (miRTo) that uses cell-endogenous microRNAs to regulate the expression of a cell death-inducing gene specifically in T-ALL cells (miRToTALL). While our innovative strategy has the potential to treat T-ALL patients more effectively and safely, it also displays market potential that extends well beyond T-ALL. This is because our technology is designed so that it can be adapted to the disease of choice or to particular disease subtypes through simple modifications, making it ideal for precision medicine in T-ALL, other cancers or other indications in which patients may benefit from the targeted delivery of a therapeutic gene. Our project will build upon the preliminary data that we have already generated, and make use of our models and expertise in the molecular and cellular biology of T-ALL, to provide preclinical validation of miRToTALL, laying the ground for a spin-off that will fully explore the miRTo technology platform.
The evolution of morphosyntactic categorization: Formal typology, diachrony, and comparative reconstruction of the mental lexicon (EVOCAT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 1960640.0
EU funding (EUR): 1960640.0
Participants: 1
Project status: SIGNED

Linguistic categories serve as cognitive tools for humans to organize, understand, and navigate the complex world around them. Categorizers - elements that formally mark lexical categories such as nouns, verbs, and adjectives - belong to the core building blocks of the mental lexicon. However, it is still unclear how and why new categories and categorizers arise and how their function changes over time. Bridging the gap between disciplines, the EVOCAT project aims to unravel this puzzle by uncovering the underlying principles that govern the formation, representation, and evolution of linguistic categories. Based on a large-scale quantitative and qualitative analysis of categorization morphology in the ancient Indo-European (IE) languages and their descendants, EVOCAT’s goal is to uncover how categorizers shape the mental lexicon, how they change over time, and how their evolution can be exploited for the purposes of phylogenetic reconstruction. The project's core hypothesis is that the rise and development of new categorizers proceeds via strictly directional reanalysis of morphological material, which predicts that categorizers develop in a uniform manner cross-linguistically and that this development gives rise to meaningful isoglosses that distinguish different subbranches of related languages from one another. This hypothesis will moreover be tested against data from non-IE languages with a comparable time span of attestation to show that it truly holds cross-linguistically. Discovering regularities and establishing universals in the domain of the mental lexicon will lead to ground-breaking insights into the nature of the categorial building blocks of human grammar. This ambitious project will provide the crucial empirical and theoretical basis for further research at the interface of language change, comparative reconstruction, linguistic theory, and psycholinguistics, and ultimately for our understanding of a core aspect of the human language faculty.

Keywords: language change,word structure,morphosyntactic change and reanalysis,comparative indo european reconstruction,indo iranian,subbranching,phylogeny,historical linguistics,theoretical linguistics
Gender Equality Plan for University of Gdańsk (GEP4UG)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: EU prize
Destination: EU Award for Gender Equality Champions
Action type: Recognition Prize
Countries involved: Poland
Call: Newcomer Gender Equality Champions (HORIZON-WIDERA-2024-GENDER-Prize, 2024)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: CLOSED

Applying for Award for Gender Equality Champions – Newcomer Gender Equality Champions University of Gdańsk (UG) is presenting its first Gender Equality Plan (GEP): “Gender Equality Plan for the University of Gdansk. Equality measures for the years 2022 – 2023”. We are demonstrating a full process that the institution has gone through including: audit, planning, implementation, monitoring and evaluation, progress achieved explaining in detail our approach which was: data-based, expert-supported, bottom-up developed and decision-maker engaging. GEP design has been based on the carefully conducted diagnosis of the current situation on equal treatment of men and women at UG. GEP has been approved by UG Rector in 2021 and became effective from 2022. As a public document, accessible from the UG website, it is aimed at all interested parties, sets out specific goals and areas of activity, entails monitoring and collection of data, promotes good practices and envisages training sessions and building of the organization’s capacity. GEP for UG comprises five goals, corresponding measures and indicators to be achieved which cover all five recommended areas of gender equality. We also present a diverse group of institution's members who have been involved in the process of design, implementation and progress assessment since the beginning. We are convinced that after completing realization of its first GEP the University of Gdansk has made substantial progress in the area of gender equality within the institution itself and has also inspired and supported other institutions in the region and beyond for a significant impact in advancing gender equality processes in higher education institutions in Poland. Based on the evaluation of the first GEP, UG has already designed and approved a second GEP for 2024-2028 to carry on the interventions for increased gender equality.

Keywords: gender equality,diversity
Biopolymer-bioglass-antioxidant composite coatings for protection of 316LVM stainless steel sternal wires against inflammation-induced corrosion (BioCoatCorr)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-07-01
End date: 2028-06-30
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 1
Project status: SIGNED

316LVM stainless steel sternal wires (SW) are widely used in cardiothoracic surgery for chest closure. However, in the aggressive environment of the human body, SWs are likely to corrode without a protective coating. This can lead to the release of harmful chromium and nickel in the surrounding tissues or, worse, SW rupture with potentially life-threatening complications, such as heart lacerations. SW degradation is caused by several factors, like chloride attack promoted by the creation of confined areas (e.g., at the chest bone/SW interface), plastic deformation due to the placement of SW around the bone, and tensile stress. Moreover, after implantation, the patient’s immune system unavoidably triggers an acute inflammation episode during which leukocytes generate reactive oxygen species (ROS), such as H2O2 and radicals (notably via the Fenton reactions), that also contribute to the SW deterioration. BioCoatCorr aims to investigate in-depth in vitro degradation of 316LVM SW in phosphate buffer saline involving simultaneously multiple degradation factors (plastic deformation, H2O2, confined areas…). For that purpose, electrochemical measurements (corrosion potential monitoring coupled with impedance spectroscopy) will be carried out at various levels of wire deformation. Furthermore, a novel zein-bioglass-cerium protective coating capable of withstanding the harsh SW operative conditions will be prepared using electrophoretic deposition (EPD). The zein biopolymer has been selected for its ductile properties required for matching the significant SW deformation. The cerium will have the functionality of ROS scavenger, limiting the polymer degradation. The anti-corrosion behaviour and mechanical properties of the coatings will be assessed as a function of the synthesis parameters. The results of BioCoatCorr will contribute to developing the next-generation SW with enhanced durability and thus improve patient life quality postoperatively.

Keywords: electrophoretic deposition,biomedical implants,inflammation,plastic deformation
European Partnership on Transforming Health and Care Systems (THCS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: COFUND actions
Partnership: Transforming of Health Systems (co-funded)
Countries involved: Italy,Belgium,Finland,France,Greece,Iceland,Ireland,Israel,Latvia,Lithuania,Netherlands,Norway,Poland,Portugal,Romania,Slovakia,Slovenia,Spain,Sweden,Malta,Estonia,Austria,Switzerland,United Kingdom,United States,Denmark
Call: European partnership on transforming health and care systems (HORIZON-HLTH-2022-CARE-10, 2022)
Start date: 2023-01-01
End date: 2029-12-31
Duration (months): 84.0
Total project cost (EUR): 305248586.69
EU funding (EUR): 91574573.0
Participants: 67
Project status: SIGNED

Health and care systems in Europe are facing core common challenges, which require harmonised and coordinated solutions. The European Partnership on Transforming Health and Care Systems (THCS) represents a unique strategic opportunity to bring together stakeholders, create synergies, coordinate Research and Innovation actions, facilitate the digitization of health and care services and support the transformation of health and care systems with innovative solutions driven by knowledge and evidence. The general objective of THCS is to contribute to the transition towards more sustainable, efficient, resilient, inclusive, innovative and high-quality people-centred health and care systems equally accessible to all people. For this purpose, THCS aims not only to create new knowledge and scientific evidence but to co-design new solutions and support their transfer and scale-up across countries and regions while also fostering capacity building. The approach for a successful and smooth implementation of THCS will focus on three main work streams: 1) Filling the knowledge gaps with research actions aiming at providing the necessary evidence, 2) Implementation and transfer aiming at supporting actions focusing on the testing of existing solutions and adaptability in different national and regional contexts, and 3) Boosting health and care systems through dedicated activities (capacity building and trainings, study visits, technical assistance, twinning, networking) involving different health and care stakeholders. To address these three work streams, THCS is built around four pillars that group different types of activities addressing different types of stakeholders of the health and care system. The activities are organised in ten Work Packages working closely together to achieve the objectives of the Partnership and clustered in the four Pillars.

Keywords: people centre health and care,good practice transferability,policy dialogue,sustainability,research and innovation funding,priority setting,capacity building for health and care stakeholders
Human mObility and cliMate change in the European context (HOME)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,Portugal
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2025-02-28
Duration (months): 26.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 2
Project status: CLOSED

Despite the increase in climate-induced migration studies, research on the topic seems to be a prerogative of researchers from the Global North focusing on case studies in the Global South. In particular, research on climate change, environment and human mobility is underrepresented in European cases, despite the increasing number of small scale disasters that displace communities in Europe every year. European countries are far from being immune to the effects of climate change and natural disasters and, just in the recent years, extreme weather events have displaced hundreds of thousands of people across Europe. Nonetheless, stories of environmental-induced mobility often remain undetected in the European context. HOME will contribute to address this geographical bias and it will adopt a political ecology approach to focus both on local experiences and practices of environmental changes and mobility in the European context, and on how they are nested in power dynamics that produce unequal distribution of climate change effects and shape im/mobility decision-making responses. On a societal level, this can better inform public policies and strengthening disaster risk and climate change adaptation governance. Portugal has been identified as an exploratory case-study with a focus on the effects of slow-onset events (e.g. sea level rise – SLR) and sudden-onset events (e.g. wildfires) on human im/mobility. The action will be conducted by the fellow Dr. Michele Dalla Fontana at the Environmental Policy Group at the Wageningen University (The Netherlands) under the supervision of Dr. Ingrid Boas, a renowned expert in the field of climate change-human mobility nexus. A secondment period of eight months is foreseen at the Institute of Social Sciences at the University of Lisbon (Portugal) under the supervision of Prof. Dr. Luisa Schmidt, who combines expertise in climate change adaptation and risks with a profound knowledge of the Portuguese context.

Keywords: human mobility climate change environmental change climate change adaptation disaster risk reduction,sea level rise wildfires political ecology european context human displacement
Amplifying the Mind with Interactive AI (AmplifAI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Finland
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-03-01
End date: 2031-02-28
Duration (months): 60.0
Total project cost (EUR): 1498118.0
EU funding (EUR): 1498118.0
Participants: 1
Project status: SIGNED

Imagine a world where the limits of human intelligence are stepping stones to greater potential. By integrating artificial intelligence (AI) systems, we can amplify and expand our cognitive abilities beyond current boundaries. Yet, there is a challenge of effectively assessing and self-assessing the combined performance of humans and AI to fully harness this potential. My project will lay the groundwork for enhancing human intellect through AI integration by addressing three ambitious objectives: (1) making AI-augmented intelligence measurable through comprehensive human-AI assessment; (2) unconstraining metacognition in human-AI interaction to improve self-assessment and empower users; (3) building AI interfaces with a metacognitive interaction model in an ability-centric design process. To achieve these goals, the AmplifAI project will undertake three interlinked work packages. WP1 focuses on conceptualizing and measuring AI-augmented intelligence by developing tasks and metrics to assess human-AI composite performance, conducting large-scale testing, and exploring neural correlates via neuroimaging studies. WP2 aims to understand and remove metacognitive constraints by studying how users assess their performance with AI assistance, using Brain-Computer interfaces to track metacognitive processes, and developing adaptive interfaces to enhance self-awareness in decision-making. WP3 involves creating new AI interfaces with a metacognitive interaction model, iteratively testing prototypes, and launching the AmplifAI Challenge. Ultimately, I envision AI seamlessly integrated into human cognition, maximizing user control and enhancing capabilities. By making both assessment and self-assessment in human-AI interactions possible, we can set the stage for breakthroughs in human-AI synergy and empower people to solve complex global challenges with AI.

Keywords: human ai interaction,intelligence,metacognition,psychology of hci,human augmentation
Identifying bio-based solutions for waste management applicable to humanitarian sector (Bio4HUMAN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Coordination and support actions
Countries involved: Israel,Spain,Poland,Czechia,France,Ireland
Call: Bio-based solutions for humanitarian applications (HORIZON-CL6-2023-CIRCBIO-01, 2023)
Start date: 2024-01-01
End date: 2026-06-30
Duration (months): 30.0
Total project cost (EUR): 1654510.39
EU funding (EUR): 1509809.06
Participants: 10
Project status: SIGNED

As the solid waste management crisis is growing in its urgency, humanitarian aid practitioners are faced with the question of how to manage environmental challenges linked with aid that is being shipped across various humanitarian settings. One of the sound solutions how to address this challenge is to open up a streamline of cooperation between humanitarian aid operators and the bio-based sector allowing them to explore the application potential of bio-based products, systems, and innovative technological solutions. Bio4HUMAN aims to contribute to the identification of bio-based solutions for solid waste management that have the potential to be applicable in various humanitarian settings. To achieve this goal, Bio4HUMAN will conduct a scoping exercise that will come up with a list of solutions but also identify existing supply chain gaps. Following that, it performs life cycle assessments of the proposed solutions and evaluates their applicability with regard to socio-economic and governance aspects. To explore if solutions fit the purpose of key solid waste management stakeholders and to explore the possibility of their acceptance by the community, local businesses, and local authorities, Bio4HUMAN conducts a feasibility evaluation process in 2 African locations. Simultaneously, the project will develop a replication roadmap that will contribute to the future replicability of the solutions identified. Altogether, all of the Bio4HUMAN’s actions will help to improve ways of addressing waste management challenges under humanitarian contexts and to the reduction of waste littered in the environment. In the long run, Bio4HUMAN is expected to contribute to the development of innovative and sustainable value chains that will benefit consumers and citizens in Europe and beyond.

Keywords: bioproducts,solid waste management,circular economy