Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High Capacity WDM System (HiCapWDM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: TERMINATED

The ever-increasing capacity demand in optical fiber communications is currently being addressed in three ways: a) Increasing the data rate carried by each wavelength channel in wavelength-division multi¬plexed (WDM) systems by using advanced optical modulation formats which offer improved spectral efficiency compared to legacy On-Off Keyed formats, b) reducing the unused bandwidth between channels by precisely controlling the transmitter wavelength and channel spacing, and c) using flexible transmission techniques to tailor the optical channels to the traffic demands in real time. A key component that enables all three of these techniques to be addressed is a low-linewidth optical comb source. The low-linewidth allows the high-order modulation formats to be used. The comb line spacing is precisely controlled so that adjacent channels will not “wander” independently and interfere with each other. The spacing between the lines can also be controlled to change the channel separation in order to allow different modulation formats and especially different symbol rates for the individual sub-channels. This allows the system to adapt to optimize the bit rate and/or modulation format depending on the available bandwidth and properties (dispersion, noise, loss, etc.) of the transmission link. For this adaptation, enhanced digital signal processing (DSP) algorithms are used. The goal of this project is to investigate high-capacity, cost effective, flexible WDM transmission systems, employing optical frequency combs and enhanced DSP technologies.

Keywords: wavelength division multiplexing,nyquist,optical comb source,orthogonal frequency division multiplexing,ofdm
New Bacterial Pathogens and Endosymbionts of the Olive Fly, Bactrocera oleae, for the Development of Innovative Fruit Fly Biocontrol Strategies (OliveFlyBacteria)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-02
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

Olive oil production is of strategic importance for most economies around the Mediterranean. One of the main pests threatening olive cultivation is the olive fly. Related insects as the Mediterranean fruit fly and the invasive fly Drosophila suzukii are mayor problems in fruti- and viticulture. Given increasing limitations to the use of chemical insecticides, innovative biological control agents and IPM strategies for these pests are highly solicited. The applicant has previously established PCR tools for the specific identification of three bacterial insect pathogens that have recently been found associated with the olive fly. During his solicited research stay at CNR-IPSP Portici and planned secondments and short stays, these tools will be employed to explore olive fly populations across Southern Italy for new potential biocontrol resources. Targeted identification will be complemented by novelty-open exploration of olive fly microbiomes. The biocontrol potential of identified bacteria will be evaluated, and transposon mutagenesis together with PTR-MS and FISH will be used to identify virulence factors as toxins or chemical attractants. This research agenda can only be implemented in a cooperation of the applicant with an infrastructurally well established partner in a Mediterranean country as CNR-IPSP. It is the scientific-technical objective of the action to develop innovative biocontrol or IPM concepts based on the experimental results obtained. It is the strategic objective of the action: i) to identify new biocontrol strains not subject to property rights of third parties, ii) to create a regional network of biocontrol researchers, bio-insecticide producing SMEs, and olive cultivators to facilitate subsequent product development for a regional market, and iii) to increase public visibility of the action and social acceptance for alternative, not only more ecosystem-friendly and sustainable, but also economically successful plant protection strategies.

Keywords: biological plant protection,microbial control,olive fly,bactrocera oleae,medfly,ceratitis capitata,drosophila suzukii,pseudomonas,providencia,rickettsiella,transposon mutagenesis,ptr ms
eHealth platform to assess patient clinical progress due to prescribed medication (DrBox)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Portugal
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The objective of prescribing medicines is to improve patient health. However, many times the expected results of medications are not achieved, which causes morbidity and mortality associated to medication use. These failures of prescription drug use have been published in numerous scientific studies and negatively affect patient health as well as cause economic damages (to patients in particular and society in general). But studies show that the majority of these failures are avoidable. Although expenses in healthcare to treat patients are high, the prevalence of morbi-mortality associated to drug prescription is high, mostly due to the fact that patients fail to follow doctor’s instructions on prescription and/or doctors duplicating therapeutics, which includes unforeseen drug interactions that can cause harm to patients. To this avail, FSaude, working closely with software developers, chemists, medical doctors and patients since 1960, has a team of 14 experts that have generated a 2,6M€ turnover in 2016, decided to develop an eHealth platform to assess patient clinical progress due to prescribed medication – DrBox. There is a market opportunity in improving a pharmacist’s capacity to provide Pharmaceutical Care, through a Therapeutics Management program, in order to reduce patient’s morbi-mortality related to drug use, improve patient’s quality of life and reduce overall costs to citizens and society. DrBox allows, for the first time in the history of modern health, the possibility for health program management entities (MD, pharmacies, nursing homes, etc.) to be able to receive in real time the epidemiological information needed to make decisions in the National Health Systems. At the present moment DrBox is being tested in three pharmacies and one nursing home, with a total of 70.000 registered users.

Keywords: bioinformatics,e health,medical informatics,health services,personalized medication,drug interactions,integrated platform,therapeutics management tool
Research and Innovation Strategy for the CIVIS Alliance (RIS4CIVIS)

Framework: Horizon 2020 — Science with and for Society
Action type: Coordination and support actions
Countries involved: Germany,Spain,Italy,Belgium,Greece,Romania,Sweden,France
Call: Support for the Research and Innovation Dimension of European Universities (Part I) (H2020-IBA-SwafS-Support-1-2020, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 1999795.0
EU funding (EUR): 1999795.0
Participants: 8
Project status: SIGNED

RIS4CIVIS is proposed by the CIVIS European University Alliance members: Universities from eight countries (BE DE EL ES FR IT RO SE), led by Aix-Marseille Université. In line with the Horizon2020 Work Programme objective to contribute to European Universities’ Research & Innovation (R&I) dimension, RIS4CIVIS will enable (A) the CIVIS Alliance and (B) European universities to maximise their potential to address 21st Century challenges through world-class R&I. For CIVIS to achieve this objective, we will develop an integrated, long-term R&I Strategy, based on our complementary strengths, but also addressing obstacles that stand in the way of deeper R&I cooperation in the following six fundamental areas: 1/ a Common R&I Strategy; 2/ Sharing infrastructures; 3/ Reinforcing Academia-Business R&I Cooperation; 4/ Strengthening Human Capital; 5/ Mainstreaming Open Science; 6/Embedding Citizens and Society. For each of these areas, we will: - Through Benchmarking, establish the current situation across our Alliance and define the ideal endpoint; - Through Consensus-Building, identify Roadmaps to reach these endpoints and to remove legal, regulatory, financial or other barriers in the short-, medium- and long-term: where the removal of barriers is not in our hands, develop Recommendations to national and European policy-makers on the way forward; - Through Case Studies, start implementing our Roadmaps, thereby testing and validating them. The knowledge gained in each of these activities, across all six areas, will inform our development of the CIVIS Research & Innovation Strategy. For other European universities, we will synthesise our six Roadmaps, as well as the benchmarking, consensus-building and case studies that went into them, into a CIVIS Institutional Transformation Model to serve as a source of inspiration for other European Universities wishing to engage in R&I cooperation as well as for the European Commission in designing its future programmes and policies.

Keywords: transformational institutional model,common research and innovation strategy,sharing infrastructures,reinforcing academia business randi cooperation,human capital,open science,citizens and society
On-chip metasurface-based neuroimaging platform toward high-throughput drug screening in freely behaving animal (FLAMMES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

A central goal of modern neuroscience is to correlate neurological conditions, external stimuli and behavior with the activity and location of individual neuron within a large brain volume. Thus, simultaneous recording of brain activity and organism behavior are fundamental to characterize circuit alterations underlying neurological disorders and to assess potential attenuation strategies. Thanks to the high degree of morphological, genetic and behavioral resemblance with humans, zebrafish is becoming a prominent model for studying neurological disorders and screening of neurospecific compounds. Owing to reduced light scattering, small size and 3R-principle compatibility of the zebrafish larvae, parallel whole-brain neuroimaging of multiple zebrafish might pave the way of in vivo drug discovery. Recent studies report technological breakthroughs that enable monitoring of zebrafish whole brain activity with cellular resolution. Although widely used for functional imaging, larval zebrafish remains limited to manual, extremely challenging and low-throughput screening. Here, I propose to integrate my solid background in biophysics and micro-nano optics engineering with new skills I will build at the Host Institution and Secondment for the project success. Goal of this project is to enable optical whole-brain imaging of multiple zebrafish larvae (Danio Rerio) freely behaving. First, I will demonstrate zebrafish larva neuroimaging with a novel metasurface-based optical sectioning illumination (Aim 1). Second, I will demonstrate selective plane on-chip detection synchronized with the excitation plane (Aim 2). Finally, I will prove potential parallel larvae on-chip microscopy (Aim 3). The proposed neuroimaging concept is a flexible approach to perform high-throughput drug screening based on recordings of the brain activity and characterization of the behavior outcome. Collectively, this study will provide a platform that contribute bridging the gap from bench-to-bedside.

Keywords: whole brain imaging,on chip microscopy,compact vision system,metasurface,drug screening parallelization,larval zebrafish,single cell resolution,behaviour
Implementation of Best Practice of Design Solid-State Power Amplifier for Developing New Generation PET Accelerators (GreenSSPA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 203852.16
EU funding (EUR): 203852.16
Participants: 1
Project status: SIGNED

According to WHO report, last updated on 2017, the rate of cancer and neurodegenerative diseases (e.g., Dementia, Alzheimer?s, and Parkinson?s disease) is rapidly increasing in both less and more developed countries. They reported that the number of people with Dementia in worldwide is projected to increase to nearly double and a half from 50 million in 2017 to 135.5 million in 2050 and also global cancer rate could increase by 50% to 15 million by 2020. Such reports are alarming scientists to enhance research domains on the diagnostic methods to identify as early as possible to improve levels of treatments. One of the best diagnostic methods for such diseases is to employ Positron Emission Tomography (PET) scanner. The PET scan technology has been under-researched and -developed for many years, and it is still ongoing updating. One of the major components of the PET scanner is cyclotron for accelerating particles. A cyclotron is the most sophisticated part of a PET installation. It makes a strong electric field to accelerate particles, results in radioisotopes. The strong electric field is usually made by a Klystron vacuum tube which is an expensive and immobile part. Hence, in hospital without a cyclotron and far away areas, it is a problem to deliver the radioactive material, as it has a short lifetime, half an hour to few hours and it costs quite a lot to ship the radioactive material by helicopter. In this project, we propose to be used solid-state technology instead of vacuum tube. It will make possible to realise a mobile and affordable cyclotron. Hence, more cyclotrons could be deployed even in remote areas, resulting a cheap and fast treatment. A high impact on both the scientific and industrial communities is predicted from the project. The project is naturally a multidisciplinary project while involving communication engineering, mechanic engineering, physics, and medical science. It is well suited with the selected research group of host organization.

Keywords: radio frequency,power amplifier,solid state material,cyclotron,accelerator
Artificial Intelligence methods for Underwater target Tracking (AIforUTracking)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-09-30
Duration (months): 31.0
Total project cost (EUR): 226801.76
EU funding (EUR): 226801.76
Participants: 2
Project status: SIGNED

The Artificial Intelligence methods for Underwater target Tracking (AIforUTracking) project will bring to the scientific community new tools for underwater target tracking by Autonomous Underwater Vehicles (AUVs) using Reinforcement Learning (RL) techniques. Moving towards the envisioned applications of marine animal tracking by autonomous vehicles, this proposal is clearly at the forefront of research, and directly addresses some of the main challenges and needs of the last Marine Strategy Framework Directive of the European parliament and of the Council, in particular establishing a framework for community action in the field of marine environmental policy. This research project will directly contribute to maintain and improve the health of the ocean by establishing innovative and unique research collaborations, and by introducing novel concepts and original research strategies that could provoke breakthroughs in the field of marine animal behavioural studies by: a) Designing and developing optimisation algorithms that leverage new RL approaches, such as Partially Observable Markov Decision Process (POMDP) and Multi-Agent Reinforcement Learning (MARL). These Artificial Intelligence (AI) tools will increase the autonomy of the AUVs while improving the accuracy of the estimated target position. b) Demonstrating the effectiveness and application of the path optimisation technique using POMPD and MARL methods by conducting real tests in the ocean, i.e. different targets will be tracked using a single AUV or multiple AUVs, as a proof-of-concept. These innovative technologies, together with Range-Only and Single-Beacon (ROSB) and Area-Only Target Tracking (AOTT) methods, are more competitive and offers greater autonomy than the traditional Long BaseLine (LBL) arrays-based methods.

Keywords: autonomous underwater vehicles,underwater target tracking,acoustic communications,biologging,acoustic tags
Ultrafast opto-electronic twists: Controlling the chirality of electrons and extreme-UV photons by ultrafast laser pulses (UCHIRAL). (UCHIRAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Chirality, describing the “handedness” of a system, is a fundamental property of physical entities such as magnets, spins, the DNA double-helix, or circularly and elliptically polarized light. This proposal aims at employing intense ultrashort laser fields to control the chirality of two physical entities: photons of extreme-UV high harmonics, and free-flying electrons in a coherent pulsed beam. Specifically, the proposal “UCHIRAL” entails two main objectives: First, we develop a bright ultrafast source of circularly polarized extreme-UV high harmonics with optically controlled helicity (left vs. right) by combining the applicant's expertise with chiral harmonics with the host's efficient source. We will then use these chiral extreme-UV pulses for imaging of nanoscale magnetic features in ferromagnetic metals, which is currently inaccessible for high harmonics. The difference between images acquired with left- vs. right-circularly polarized extreme-UV radiation can isolate magnetic effects from a non-magnetic background. In a second system, we will coherently convert the chirality of optical near-fields into orbital angular momentum of a beam of free electrons. This interaction will be mediated by designed nanostructures exhibiting surface plasmon-polariton excitations with optically-controlled chirality. The envisaged mechanism relies on optical phase control of free electron wave functions in an ultrafast transmission electron microscope, which was recently established in the host institute. Both aspects of the proposal address fundamental interactions of chiral light with matter, currently at different levels of maturity, with expected scientific and potentially industrial applications. In particular, ultrafast chiral microscopy based on photons (first objective) and electrons (second objective) may enable future technologies by tracking chiral dynamics in nanosystems with intrinsic handedness, ranging from magnetic storage materials to biomolecules.

Keywords: ultrafast physics,high harmonic generation,chirality,lens less imaging,utem,vortex beams
Chemometers for in situ risk assessment of mixtures of pollutants (CHEMO-RISK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-05-01
End date: 2023-07-31
Duration (months): 75.0
Total project cost (EUR): 1496030.0
EU funding (EUR): 1496030.0
Participants: 1
Project status: SIGNED

CHEMO-RISK aims for a novel scientifically sound chemical risk assessment paradigm that integrates exposure and effect assessment of a broad range of chemicals into a single procedure and provides information relevant to ecosystem and human health. The key innovation is polymer “chemometers” that will be equilibrated with their surroundings and deliver information on the pollutant’s chemical activity in the environment, biota, and humans. A chemometer functions analogously to a thermometer, but instead of the temperature, it yields a measure of chemical activity. Chemical activity in turn indicates the thermodynamic potential for, e.g., partitioning, biouptake and toxicity. CHEMO-RISK aims at breaking the current paradigm in environmental risk assessment of single chemicals that disregards bioavailability, ignores mixture effects, lacks site-specificity and is difficult to extrapolate to human health. The chemometer extracts will be investigated using top-notch (a) GC and LC/Orbitrap chemical analysis to characterise the pollutant mixtures and (b) cell-based reporter gene bioassays to determine mixture effects covering baseline toxicity, specific (e.g., endocrine disruption) and reactive (e.g., genotoxicity) modes of toxic action and adaptive stress responses. Within CHEMO-RISK, the following important research questions will be tackled: (A) Which processes drive the enrichment of pollutants in aquatic biota on a thermodynamic basis? (B) How do pollutants distribute within an organism, and which effects do they elicit at the key target sites? (C) Can we apply everyday-life items such as eyeglass-nose pads to replace invasive sampling in human health risk assessment? (D) To which degree can non-target analysis of chemometer extracts explain the observed toxicity profiles across media? By combining all these research efforts, CHEMO-RISK will provide a unified risk assessment paradigm with risk-based trigger values distinguishing acceptable from unacceptable effects.

Keywords: chemical activity,chemometer,pollutants,chemical exposure,toxic effects,bioassays,aquatic environment,sediment,water,biota,humans,tissue,blood,bioaccumulation,unified risk assessment