Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
An iono-electronic neuromorphic interface for communication with living systems (IONOS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France,France
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-11-01
End date: 2024-10-31
Duration (months): 72.0
Total project cost (EUR): 1898520.0
EU funding (EUR): 1714095.0
Participants: 4
Project status: SIGNED

While our understanding of the brain have made huge progresses, we are still inefficient in interfacing biological systems with electronics, both in terms of energy and integration potential. Pushed by the need to use conventional computers for building complex systems dedicated to brain interface applications, we have mostly capitalized on technologies and architectures inherits from microelectronic that are intrinsically not adapted to interface living systems. The IONOS project will shift the brain interface paradigm by developing new technologies designed to interact intimately with biological cells and capitalizing heavily on bio-inspiration. To reach this goal, the IONOS project will explore how to sense, stimulate and compute biological signals from in-vitro neural cells’ assembly based on iono-electronic materials and devices. These emerging devices offer basics functionalities such as memory, ion-electron signal’s transduction, and amplification paving the way to a new field of device and circuit engineering that could efficiently reproduce key biological functions such as learning and spatio-temporal processing of information. This project will demonstrate how these concepts associated to the bio-inspired computing paradigm can unlock our fundamental limitations for communicating with living neural cells. Proof of concept will show how an artificial system can efficiently send, receive and compute information from a biological one, which constitutes the basic of communication.
TArgeTed molecular Imaging and surgery for gastro-intestinal Cancer (TAcTIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-08-01
End date: 2021-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 128750.0
Participants: 2
Project status: CLOSED

The treatment for cancer patients is shifting from population-based treatment to the more precise personalized medicine. Tumor-specific molecular diagnostics and treatment are an example of this phenomena to assist clinical decision making and to improve treatment strategies for patients. This change in management will lead to societal benefits such as treatments that fits the patient’s needs and therefore, increased health benefits and increased quality-of-life. The targeted agent we have developed has both an imaging version to improve the detection and resection of cancer and an cytotoxic variant to eliminate potential remaining tumor cells. At this point, there is no agent available that can contribute to both the diagnostic phase and the subsequent treatment in a tumor-specific manner. Near infrared (NIR) fluorescence imaging is a technique that has gained a lot of attention over the last decade because of its role in intra-operative guidance to improve resection, and in, for example, endoscopy to improve detection. Combining a NIR-dye to a specific tumor-targeting ligand, like an antibody or a peptide, dramatically enhances the specificity, providing a solid real-time identification and demarcation technique. In TAcTIC, we propose the clinical introduction of a targeted fluorescent imaging agent against EpCAM, which can also be used for response monitoring during endoscopy, and the initiation of a New Company (in the Netherlands) via a joint venture between LUMC and ElevenBio (Boston, United States) for the future commercialization of this agent. The expected outcomes of this proof-of-concept project are the successful introduction of a novel targeted fluorescent agent for in multiple cancer types, a joint venture between LUMC and ElevenBio for the commercialization of this agent, and societal benefits for the patient in the form of increased health benefits and quality of life due to a treatment strategy that fits the individual patient’s needs.

Keywords: early cancer detection,tumor targeted diagnosis and treatment,surgery,near infrared fluorescence
Sustainable optimization of the value chain of added-value fresh and dried berries through the integration of Precision Agriculture management strategies and innovative dehydration and edible coating (FRIETS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Cyprus,Malta,Greece,Romania,Greece,Greece,United Kingdom,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 2433400.0
EU funding (EUR): 2433400.0
Participants: 13
Project status: SIGNED

Maintaining a healthy diet requires sufficient consumption of fruits and vegetables. However, nowadays, the fast pace of modern lifestyle discourages individuals from reaching their optimal daily intake via consumption of fresh fruits/vegetables, ultimately creating an increasing demand for natural, nutritive, healthy and personalized ready-to-eat snacks. It is also an accepted actuality that there is a lack of healthy food snacks for personalized nutrition in the market. Hence, the development of such products, which can also be tailor-made to the needs of specific groups (young children, elderly, diabetic, sportive etc.), is a long-awaiting innovation. FRIETS project aims in training crossdisciplinary scientists from 5 European countries, in collaboration with international SMEs, for the development and marketization of personalized, nutritious and innovative, soft fruit smart snacks that contain no added sugar, sodium or chemical preservatives, as a palatable way to increase daily fruit consumption. FRIETS smart snacks will include novel processed berries (strawberry, raspberry and blackberry) with superior quality and nutritional characteristics, as well as extended shelf-life. Pre-harvest management practices will be optimized for cultivating high-quality berries. Low impact post-harvest technologies will be developed and optimised including (1) mild and energy efficient drying techniques (e.g. osmotic dehydration, freeze drying, microwave vacuum drying or their combination) using limited or no sugar or salt, and low temperatures, (2) composite or multi-layered edible coatings, based on micro- and macro-algae components, including encapsulated or non-encapsulated natural functional ingredients. Life Cycle Analysis and socio-techno-economic analysis will be implemented for the sustainable development of new products. FRIETS implementation will be based on staff secondments, strengthening collaborative research among different countries and sectors.

Keywords: smart snacks,osmotic dehydration,freeze drying,microwave vacuum drying,low sugar salt,microbial analysis,bioactives extraction and encapsulation,pre and post harvest management
Enhancement of UV stability of thermally modified wood through envelope impregnation with nano-based stabilisers (NewSiest)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Slovenia
Call: Widening Fellowships (H2020-WF-01-2018, 2018)
Start date: 2020-02-03
End date: 2022-02-02
Duration (months): 24.0
Total project cost (EUR): 162040.32
EU funding (EUR): 162040.32
Participants: 1
Project status: CLOSED

Thermal modification is a process which improves the properties of wood, resulting in a material that can be disposed at the end of the product life cycle without presenting an environmental hazard. Thermally modified wood retains as a natural product and the grain, original colour variances and characteristics of wood are still present. However, exposure to daylight causes brightening or graying of heat treated wood surfaces. In ordar to tackle this challenge we are proposing a novel way to improve the UV stability of thermally modified wood using nano based stabilizers. But instead of coating nanoparticles on heat treated wood, wood surfaces will be treated with nanoparticle (ZnO or CeO2) solutions, thereby forming protective envelope on a wooden surface, which will be further heat treated under controlled temperature and time. This technique induces a chemical bonding between the wood and nanomaterial thus protecting chromophoric groups from UV light degradation.

Keywords: wood,thermal modification in vacuum,nanoparticles,ceo2,envelope treatment,resistance against uv light,colour,resistance against fungal decay
Microplastics: morphological and genetic developmental effects in a marine invertebrate. (MICRODEV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-09-15
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: SIGNED

Plastic debris contamination is a growing environmental concern in marine habitats. Large plastic objects break-up over time to create micro- and nano- particles, collectively called microplastics (MP), which account for the overwhelming majority of plastic particles in the sea. Little is known about the impacts of MP on wildlife or humans and this presents an important research priority. Several studies have demonstrated that MP can affect sea life negatively. Amongst these, they have been reported affecting development (causing malformations, delayed growth and increased death rates). These developmental effects have never been characterised, and their molecular basis remains unknown. Developmental defects may impact population survival by decreasing the number of individuals, or their fitness, in range of marine organisms. This pioneering project will identify the effects of MP exposure in the development of the sea urchin Paracentrotus lividus, bridging interests for ecology, toxicology, developmental biology and aquaculture. I will characterise the developmental morphological malformations caused by MP and their underlying genetic mechanisms. This Fellowship will provide an excellent opportunity to complement my strong background in genetics and molecular and developmental biology and expertise in ecotoxicology and microplastic pollution with transcriptomic analysis and the deep understanding of this model organism for development and toxicology under the supervision of Dr. Arnone, a world leading expert in the field. This will provide me with a firm skill set and knowledge to further my research career. The knowledge and expertise I will acquire in the Arnone lab, together with being hosted by a supportive and acclaimed institution, and the prestige of the MSCA fellowship, will allow me to open a unique and timely line of research and will be crucial for my transition into an independent European researcher.

Keywords: microplastics,developmental biology,embryo,larvae,transcriptomics,ecotoxicology,sea urchin,nanoplastics,chemical load
New Electric Vehicle Chassis-Cab 10-14 for urban logistic (NEC14)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: France
Call: Small business innovation research for Transport (H2020-SMEINST-2-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 2492435.0
EU funding (EUR): 1744704.5
Participants: 1
Project status: CLOSED

Muses is an electric chassis-cab manufacturer for deliveries (parcels minus 30 kg) in cities. Our vehicles (Mooville) received the N1 (-3T5) homologation for a volume up to 9 cu.m. Mooville is the only electric N1 chassis-cab with this capacity in Europe. The objective of NEC14 program is to launch, on European market, an electric designed vehicle 10-14 cu.m, in response to the high demand of European delivery actors. Cities need to have sustainable deliveries, emitting neither gas nor noise pollution, as wished by U.E. citizens. Major delivery actors look for reliable, zero CO2, zero fine particles, zero db vehicle, business relevant and industrial solution, with the right Total Cost of Ownership. For example 3 of our customers, Chronopost International, DHL and EXAPAQ-DPD have their current fleet of thermal vehicles with volume between 10 and 12 cu.m. and a TCO around 1100 € per month. They are definitely interested by our NEC14 project, and have insisted to be actor of it. Today there is 3 categories of vehicles: quadricyle, N1 (-3t5), trucks. It exist many small electric quadricycles. Gaz and electric trucks (up to 12 tons and plus) also exist. But in the “-3T5” category the only vehicles are derived from person vehicles (like Renault Kangoo, …) and offer less than 4 cu.m. Above that nothing between 5 cu.m and 16 cu.m. Our customers, our leasers confirm this current, and for still 3 years at least, situation: Mooville 4-9 is the only one vehicle and not any 10-14 cu.m clean vehicle on European market. Some of our Clients such as Exapaq (DPD), DHL and Chronopost, world leaders in the delivery business, have already decided to support us (See enclosed interest letter of these three companies). They will participate in the different stages of NEC14 program. NEC14 is a two years project which includes [1] three prototype vehicles to be tested by partner clients, [2] a marketing and commercial action plan and [3] the preparation of the sales force implementation.

Keywords: green transports,green vehicles,electric urban delivery vehicle,electric commercial vehicle,wheel motor,urban mobility
Taming the particle transport in magnetized plasmas via perturbative fields (3D-FIREFLUC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Spain
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-05-01
End date: 2024-04-30
Duration (months): 60.0
Total project cost (EUR): 1512250.0
EU funding (EUR): 1512250.0
Participants: 1
Project status: SIGNED

Wave-particle interactions are ubiquitous in nature and play a fundamental role in astrophysical and fusion plasmas. In solar plasmas, magnetohydrodynamic (MHD) fluctuations are thought to be responsible for the heating of the solar corona and the generation of the solar wind. In magnetically confined fusion (MCF) devices, enhanced particle transport induced by MHD fluctuations can deteriorate the plasma confinement, and also endanger the device integrity. MCF devices are an ideal testbed to verify current models and develop mitigation / protection techniques. The proposed project paves the way for providing active control techniques to tame the MHD induced particle transport in a fusion plasma. A solid understanding of the interaction between energetic particles and MHD instabilities in the presence of electric fields and plasma currents is required to develop such techniques. I will pursue this goal through innovative diagnosis techniques with unprecedented spatio-temporal resolution. Combined with state-of-the-art hybrid MHD codes, a deep insight into the underlying physics mechanism will be gained. The outcome of this research project will have a major impact for next-step MCF devices as I will provide ground-breaking control techniques for mitigating MHD induced particle transport in magnetized plasmas. The project consists of 3 research lines which follow a bottom-up approach: (1) Cutting-edge instrumentation, aiming at the new generation of energetic particle and edge current diagnostics. (2) Unravel the dynamics of energetic particles, electric fields, edge currents and MHD fluctuations. (3) From lab to space weather: The developed models will revolutionize our understanding of the observed particle acceleration and transport in the solar corona. Based on this approach, the project represents a gateway between the fusion, astrophysics and space communities opening new avenues for a common basic understanding.

Keywords: plasma physics,solar physics,energetic particles,particle transport and acceleration,magnetohydrodynamics,electric fields,plasma currents,magnetic confinement
Simulation of Cardiac Devices & Drugs for in-silico Testing and Certification (SimCardioTest)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Norway,Belgium,France,France,France,France,United States
Call: Accelerating the uptake of computer simulations for testing medicines and medical devices (H2020-SC1-DTH-2020-1, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 7965875.0
EU funding (EUR): 7965875.0
Participants: 10
Project status: SIGNED

Despite massive investment in healthcare, huge R&D cost increase and regulatory pathway complexity hamper tremendously commercialisation of new devices & medicines, putting patient populations at risk of not receiving adequate therapy. At the same time, outside healthcare, computer modelling and simulation (CM&S) is precisely recognised to increase speed & agility while reducing costs of development. CM&S can create scientific evidence based on controlled investigations including variability, uncertainty quantification, and satisfying demands for safety, efficacy & improved access. Cardiac modelling has dramatically gained maturity over the last decades, with personalisation to clinical data enabling validation. We selected a number of cardiac devices and medicines where CM&S is mature enough and that represent the most common cardiac pathologies, to demonstrate a standardised and rigorous approach for in-silico clinical trials. SimCardioTest will bring a disruptive innovation by creating an integrated and secure platform standardising & bridging model simulations, in-silico trials, and certification support. This environment will go beyond the state-of-the-art in computational multi-physics & multi-scale personalised cardiac models. Diseased conditions and gender/age differences will be considered to overcome clinical trials limitations such as under-representation of groups (e.g. women, children, low socio-economic status). Advanced big data, visual analytics & artificial intelligence tools will extract the most relevant information. It is critical that Europe demonstrates its capacity to leverage in-silico technology in order to be competitive in healthcare innovation. SimCardioTest exploitation aims at delivering a major economic impact on the European pharmaceutical and cardiac devices industry. It will accelerate development, certification and commercialisation, and will produce a strong societal impact contributing to personalised healthcare.

Keywords: cardiology,medical devices,medicines,regulatory approval,in silico trials
BElgian WAllonia REsearcher FELLOWSHIPS 2 (BEWARE2)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Belgium
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2018, 2018)
Start date: 2020-09-01
End date: 2027-08-31
Duration (months): 84.0
Total project cost (EUR): 14344200.0
EU funding (EUR): 7172100.0
Participants: 1
Project status: SIGNED

To promote the mobility of researchers towards Wallonia, the BEWARE 2 programme (Belgian Wallonia Researcher Fellowships) will grant about 65 mandatesto attract researchers in SMEs, accredited research centres and universities / university colleges. Fellows will share their working time between the premises of two hosts choosing among three hosting possibilities: - a university and a company - a college and a company - an accredited research centre and a company A fair breakdown of 50/50% is expected. Furthermore a short stay outside Wallonia could be envisaged.

Keywords: mobilty,researcher,wallonia,belgium,university,university college