Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrated SERvices supporting a sustainable AGROecological transition (AgroServ)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Services and infrastructures
Action type: Research and Innovation actions
Countries involved: United Kingdom,France,Portugal,Germany,Belgium,Israel,Italy,Serbia,Ireland,Finland,Austria,Czechia,Sweden,Norway,Greece,Spain,Poland,Netherlands,Romania,Slovenia,Denmark,Switzerland,Lithuania,Bulgaria
Call: Research infrastructures services for a sustainable and resilient agriculture and agro-ecological transitions (HORIZON-INFRA-2021-SERV-01, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 14252873.35
EU funding (EUR): 14252873.35
Participants: 74
Project status: SIGNED

Developing a resilient and sustainable agriculture system, and the agroecological transitions requires a deep understanding of agroecosystems, their interactions with the environment, and management practices. AgroServ features a large consortium of research infrastructures, most of them being on the EU roadmap, and a vast offer of services at all scales, from the molecule to the organism, to the ecosystem, to the society. AgroServ will facilitate a systemic and holistic approach to understand the threats and challenges agriculture is facing, towards the implementation of a resilient and sustainable agri-food system. We propose a transdisciplinary offer of services, integrating the actors of the agriculture system in the research process, of which the farmers are the first, thanks to a wide offer of living labs across Europe. Most of the relevant field of sciences are represented in AgroServ, from natural to social sciences. We will develop a wider catalogue of integrated and customized services, thanks to a specific approach of service pipelines designed from a gap analysis, stakeholder and user demands. A strong community building and training program for access managers and users will be implemented to facilitate multi- and transdisciplinary research with all relevant actors. Results from the research performed under AgroServ will be synthetized to be used in the scope of evidence-based policy making. Data from AgroServ will be open and compliant with FAIR practices, and made available on the long-term to the communities, and be linked with the main European initiatives, as the EOSC. Strong links will be established with existing or future programs under H2020 and Horizon Europe, such as the partnerships agroecology, living labs and research infrastructures, and agriculture of data, as well as the two CSA AE4EU and ALL-READY, and the missions soil and plant health, and waters. AgroServ will collaborate with other relevant initiative in the Pillar II to of HE.

Keywords: sustainable agriculture,agroecology,agronomy,transdisciplinary research,living labs,food security,one health animal well being,human well being,rural communities,climate change adaptation
Digital Personalized AI Based Platform Training Parents and Therapist to Develop Children with autism everyday Interaction (SocialMind)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Israel
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-07-01
End date: 2023-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

An intensive evidenced-based therapy in the early years of a child with autism determine the child's developmental trajectory. Children with autism don't get the therapy they need due to lack of qualified therapists and lack of training. SocialMind developed a platform that trains parents and therapists to turn every interaction into an evident-based opportunity. The company developed a protocol that is based on ESDM (Early Start Denver Model) and PRT (Pivotal Response Treatment) autism evidence-based intervention. SocialMind broke down these comprehensive interventions into a series of concrete parenting skills, that motivate the child to interact and learn throughout the day. An essential component of the solution is based on the ability of the parent to upload a video of themselves interacting with their child and get a response from our Hybrid-Response system: AI software analyzes the audio and visuals, and then a member of our community of qualified reviewers (parents that are our mega users, and students) goes over and complements the machine assessment. The company has so far helped 150 children progress. In the uploaded video the company annotates child and parent behaviors and makes a "basic behavior annotation" that enables an accurate and efficient review and feedback, feedback is generated that is synchronized to the interaction, and sent back to the parent. A second machine analysis will be used on the feedback to identify errors and alert the expert level before the feedback is sent back to the parent. Based on data collected from home interactions, the system will learn novel therapy insights from analyzing child development characteristic, parent implementation characteristics, and the best intervention skill that the parent should learn to optimize their child's development at the current stage.

Keywords: autism early intervention,digital health,access to health
Macrophage-based immunotherapy of platinum-resistant ovarian cancer (MACOV)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Poland
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2022-11-01
End date: 2026-04-30
Duration (months): 42.0
Total project cost (EUR): 2499998.75
EU funding (EUR): 2499998.75
Participants: 1
Project status: SIGNED

Resistance to platinum-based chemotherapy is a major clinical challenge in ovarian cancer. About 300,000 women are diagnosed with ovarian cancer each year and the number of deaths is estimated at 180,000 worldwide each year. Ovarian cancer metastasizes early in its development, often before it's diagnosed. Ovarian cancer treatment involves surgery with frontline platinum-based chemotherapy. As many as 15-30% of patients with ovarian cancer have primary platinum-resistant or refractory disease. The recurrence of ovarian cancer is now considered a sign of an incurable disease (it becomes platinum-resistant). The project MACOV aims to develop an innovative allogeneic, “ready-to-use” macrophage-based therapy for platinum-resistant ovarian cancer. This is a ground-breaking, first in class therapy that shows very high efficacy in multiple solid tumors of unmet medical need. These cells are equipped with targeted therapy drugs complexed with the carrier protein ensuring their stability in the carrier cell. The protein-drug complex is transferred specifically to cancer cells. The whole concept of this cell therapy is based on the groundbreaking scientific discoveries of MDC (Macrophage-Drug Conjugate). Two European Research Council (ERC) grants were received to study the molecular basis of the discovered mechanism - in 2016 and 2020. In 2018 this project was selected to be promoted as one of the 10 European projects during ERC 10th Anniversary. The MACOV project will generate of complete efficacy data package for the pre-clinical development of MDC-735 product, consisting of efficacy in multiple animal models for platinum-resistant ovarian cancer, PK, PD and toxicology study as well as consolidate IP and validate business case. The result of the project will be a validated cell therapy product for platinum-refractory ovarian cancer, tested for effectiveness and ready-to-use for the Phase I clinical trial.

Keywords: cell therapy,macrophage,immunotherapy,ovarian cancer
the role of Stress History on the EARthquake potential of faults (SHEAR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-14
End date: 2024-07-13
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: CLOSED

The extent to which earthquake phenomena can be accurately assessed ultimately depends on how well the underlying physical processes are understood. Earthquake physics is primarily controlled by fault frictional properties and fluid pressure, which have been widely tested in laboratory rock deformation experiments. During the last 50 years, these experiments have provided fundamental contributions to our understanding of earthquake physics. However, in most experiments, the fault is loaded toward earthquake-slip under constant effective normal stress or via an increase in effective normal stress, i.e., load-strengthening. Nonetheless, numerous natural faults are affected by a reduction in effective normal stress during tectonic loading, i.e., load-weakening, and this condition is dominant in induced earthquakes due to fluid-injections in modern energy production. Further, along mature fault zones characterized by a thick damage zone and fault core, load-weakening likely promotes fault dilation, instead of compaction, with strong implications for fault hydro-mechanical behaviour. With SHEAR, I propose to fill this knowledge gap via laboratory experiments designed specifically to investigate the influence of loading path, and in particular the load-weakening path in fault physics, taking advantage of a world-class deformation apparatus. Laboratory results will be integrated with acoustic techniques to shed light on the physical processes at play and inform microphysical models that, coupled with field studies, will allow for the upscaling of experiments and provide a broader comprehensive picture of tectonic faulting. For the SHEAR action, the experience I acquired during my Post-Doc at EPFL (Switzerland) will be fundamental. The vibrant research environment in Sapienza will give me the possibility to acquire new scientific and transferable skills, ensuring me a competitive scientific profile to successfully apply for positions in academia, public and private sectors.

Keywords: stress history,loading path,friction,rock deformation experiments,faults,microstructures,earthquake physics
Exploiting the activity of the ALDH enzyme to develop highly selective drugs for cancer stem cells (SeleCStem)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 1499948.0
EU funding (EUR): 1499948.0
Participants: 1
Project status: SIGNED

Despite huge advances in cancer treatment, resistance to chemotherapy is still common. It is now well established that a small population of cells named cancer stem cells (CSCs) have high tumorigenicity and are able to initiate and maintain a tumour. CSCs usually remain in a quiescent state that is not affected by standard chemotherapy; thus, they are often responsible for treatment resistance and relapse. There is a clear need to find effective treatments against CSCs to fully eradicate the tumour. However, the close similarities of CSCs to healthy stem cells hinders the identification of selective drugs. In the last years, new drug modalities are emerging to provide therapeutic options for challenging targets and diseases, expanding the drug discovery landscape. In line with these trends, SeleCStem aims to develop innovative chemical biology strategies to target CSCs in a safe and effective manner. It will exploit the activity of the enzyme ALDH, which is overexpressed in CSCs of many cancer types, to obtain selective drugs using three orthogonal strategies: we will use the oxidoreductase activity of ALDH to trigger the selective (1) accumulation or (2) release of drugs inside CSCs and (3) use external light to inhibit ALDH only in the tumour area. Successful strategies will be combined at the end of the project to overcome potential limitations of the individual approaches, hence massively increasing the drugs’ selectivity and efficacy. We will design these molecules with the aid of docking studies, synthesise them, and assess their ALDH- or light-triggered activation in purified enzyme assays and in CSC spheres. Overall, we will develop the proof of concept of unprecedented approaches to eliminate CSCs with outstanding precision, thus overcoming some of the limitations of conventional small molecules going beyond state-of-the-art chemical biology. Our ultimate goal is to contribute to improve cancer treatment and increase complete remission rates.

Keywords: cancer stem cells photopharmacology drug selectivity aldh
Theory and principles of luminescent organic radical materials for OLED and sensor applications (LUMOR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Organic luminescent radicals (OLRs) are quite rare emitters demonstrating doublet-doublet fluorescence and having a number of advantages towards practical applications in organic light emitting diodes (OLEDs), ratiometric fluorescence sensors and anti-counterfeiting labelling. The doublet-doublet fluorescence by OLRs is a spin-allowed process similarly to the common singlet-singlet fluorescence. But in contrast to closed-shell molecules for which “bright” excited singlet states are higher in energy than “dark” triplet states, the doublet excited states of OLRs are always lower in energy than the quartet states. That is why the theoretical limit for internal quantum efficiency of OLR-based OLEDs is expected to be 100% and why the quartet excited states in general have not been considered for OLRs. However, recent experimental studies indicate that quartet states of OLR emitters indeed can be populated in OLEDs so reducing their efficiency. Thus, in the current project I aim to develop general theory and principles of OLRs in order to involve quartet states into the emission process and to boost the efficiency of OLEDs beyond state-of-art results. Another challenge for this project is design of OLRs for sensor applications. Most of OLRs possess low-lying first excited doublet state that makes them perfect anti-Kasha emitters for which emission occurs from higher excited states, something that is rare for closed-shell systems but required for ratiometric fluorescence sensors. In this project I aim to extend the principles of anti-Kasha emission for OLRs to make a breakthrough in state-of-art ratiometric detection of radicals. Finally, the special kind of sensing called two-step anti-counterfeiting labelling will be developed in this project based on photoresponsive aromatic carbonyls. These compounds are environment friendly, they can easily generate stable OLRs upon UV irradiation that I will utilize for innovative anti-counterfeiting application.

Keywords: radical oled fluorescence phosphorescence sensor doublet state quartet state anti kasha emission spin statistics
Glyco-protein arrays for functional virus surveillance (arrayed surveillance)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-08-01
End date: 2026-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

This ERC PoC project aims to establish the technical and commercial feasibility of our recently developed glycan-arrays in which we determined the minimal receptor for duck, chicken, and human influenza A viruses, respectively. We also determined structures vital for viruses as intermediate receptors on the avian-mammalian interface. With our experience in printing arrays, we also want to add proteinaceous receptors for coronaviruses. This mixed “glyco-protein” array will then be employed for functional surveillance of two virus families with significant pandemic threat. The ERC program “sugar-enable” has developed different glycan arrays that should be used in the real world to detect potential pandemic viruses as soon as possible, now making a substantial societal impact. In this project, we aim to conduct a technical and commercial feasibility study.
ICE coupling protein inhibitors (ICECOUP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-03-15
End date: 2026-03-14
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: TERMINATED

Antibiotic resistance (AR) is one of the greatest threats to human health. The global overuse of antibiotics has resulted in the proliferation and dissemination of antibiotic resistant bacteria harboring a multitude of antibiotic resistance genes that can be mobilized by different horizontal gene transfer processes such as conjugation. Integrative Conjugative Elements (ICEs) are mobile genetic elements which are typically found integrated in the bacterial chromosome and encode the machinery for their conjugation. The so-called coupling proteins have a critical role in the conjugation process. ICECOUP is focused on the molecular and functional characterization of a critical component for ICE transmission, the coupling protein, with the ultimate goal of finding ICE conjugation inhibitors to block or, at least, minimize the AR spread. To date, ICE coupling proteins have received little attention despite their importance in the transfer mechanism. The supervision of Dr. Itziar Alkorta at the University of Basque Country(UPV/EHU) is a key element to guarantee the success of this project. ICECOUP will generate extensive and innovative scientific outputs that in the long run will have a societal impact, enhancing the catalogue of weapons to combat antibiotic resistance. The multidisciplinary approach of ICECOUP will allow me the reinforce my scientific knowledge and soft skills, while I acquire outreach and project management capacities. Undoubtedly, should this project be funded, it will strengthen my prospects to forge a stable career as an independent researcher able to secure funding.

Keywords: conjugation,coupling proteins,antibiotic resistance
Emerging pests and pathogens as a novel lens for unravelling social-ecological cascades (INFLUX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 1499705.0
EU funding (EUR): 1499705.0
Participants: 2
Project status: SIGNED

Emerging pests and pathogens (EPPs) are an increasingly disruptive force to human society that can cause large social and ecological changes far beyond their initial site of emergence. Three forces contribute to this growing challenge now and in the foreseeable future: first, potential EPPs are more likely to come in to first contact with human habitats as human land use expands. Second, denser human trade and travel networks mean that EPPs are more likely to emerge in new regions. Third, human technology, such as biocidal agents, increases risks for re-emergence. Understanding how EPPs cascade across scales in social-ecological systems is therefore an urgent priority, but no formal approach currently exists for analysing the ripple effects at scale, from their seeding to their lasting societal imprints. This project aims to fill this gap in sustainability science for society. The INFLUX project will test the hypothesis that EPPs commonly cascade to interact with large-scale social and environmental challenges and that small differences in social-ecological conditions in turn influence the likelihood and nature of EPP cascades. I will test this hypothesis by leveraging a comparative, mixed-methods research design to assemble a large database for up to 1600 EPPs, encompassing microbial pathogens as well as arthropod and plant pests. Specifically, four objectives will be pursued, which are to understand: 1. The drivers of emergence risk and their connections to human environmental sustainability and social conditions. 2. The types of cascades that result from action aimed at governing EPPs. 3. The lasting impacts EPPs have on societies and the conditions under which they arise. 4. The feedbacks from 3.-1. including through implications for social equity and environmental sustainability. INFLUX constitutes a major step in situating EPPs in the field of sustainability science, and for developing societal capacity to navigate a future characterized by them

Keywords: emerging pests and pathogens,social ecological systems,cascading cross scale dynamics,anthropocene