Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advancing Mountable Endoscopic Cap for Precision Oesophageal Mucosal Resurfacing with Non-Thermal Ablation (CLARISURGE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Türkiye
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1596250.0
EU funding (EUR): 1596250.0
Participants: 1
Project status: SIGNED

Treatments that minimize adverse effects on deep tissues may be critical for successful therapy in a superficial pre-cancerous condition such as Barrett's oesophagus. Although endoscopic therapeutic interventions efficiently eradicate superficial abnormal tissues in the oesophagus, the main challenge with their current deployments is that the therapy depth typically has a more profound thermal injury than the target layer. The project's objective is to develop a novel endoscopic cap that provides local non-thermal ablation to the superficial layers of the target oesophageal wall with sufficient depth for mucosal resurfacing. A design compatible with endoscopes will enable navigation, diagnosis, and ablation together—all-in-one. In support of the objective, the research programme is split into the following indicative specific aims based on EU MDR (2017/745) ISO (13485) & TSE (60601) regulations. Aim-1: Development of numerical modelling to mimic non-thermal ablation dynamics of the endo-cap. Aim-2: Optimization of numerical modelling with computational accuracy by in-vitro studies. Aim-3: Establishing the quality control process. Aim-4: Configuration of the endo-cap's original design in a CAD program and then realize the design with an optically transparent material containing electrodes for a porcine animal model, in vivo. Aim-5: Integration of the endo-cap with an endoscopy system to construct an endoscope equipped with the endo-cap for preclinical trials. Aim-6: Investigating the functional feasibility of an endoscope system in a GI endoscopy simulator. Aim-7: Validation of the system's oesophageal mucosal resurfacing performance in an in vivo porcine model, including tissue samples for histology examination at different time points. The action results are thought to mature the original design sufficiently for clinical trials and provide further steps for introducing the oesophageal mucosal resurfacing technique using non-thermal ablation into clinical routine.

Keywords: endoscopic treatment,irreversible electroporation,mucosal ablation,barrett s oesophagus
Using ex vivo functional genomics as biomarker to predict the effectivity of Venetoclax in patients with acute leukemias (PREDICT THE DRUG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2024-01-01
End date: 2025-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

For decades, oncologists treating cancer patients desire biomarkers that predict drug sensitivity on a patient individual level; unfortunately, the challenge remains unsolved until today. As treating clinicians are unable to identify the patients who benefit most and despite advanced multi-omics diagnostics, the majority of cancer patients are treated according to risk groups. As a result, patients receive inactive drugs without benefit, but adverse effects and European healthcare systems lose significant resources without gain. During my ERC CoG work, we developed a completely new test principle which has the potential to bridge the gap. The group of “targeted” anticancer drugs causes tumor cells to die by inhibiting a single specific signalling molecule; we used the CRISPR/Cas9 mediated gene knockout to mimic the activity of such targeted drugs. In proof-of-principle work, we used patient-derived xenograft (PDX) leukemia models to show that the knockout of a target gene in vitro was able to predict which patient´s PDX model responded to treatment with the respective drug in vivo. Here, we plan to optimize our test system by studying knockout of BCL-2 to predict sensitivity to the BCL-2 targeting drug Venetoclax. The planned work harbours the potential of a major breakthrough to solve a long-standing challenge in anti-cancer treatment, namely to predict which individual patient´s tumor responds to which targeted.
Optimizing Production and Logistic Resources in the Time-critical Bio Production Industries in Europe (CLARUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Italy,Finland,Spain,Austria,Luxembourg
Call: AI, Data and Robotics for the Green Deal (AI, Data and Robotics Partnership) (IA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-09-01
End date: 2025-11-30
Duration (months): 39.0
Total project cost (EUR): 3423230.75
EU funding (EUR): 2999105.75
Participants: 10
Project status: SIGNED

The CLARUS project aims to connect the Sustainable Paradigm in the food industry and AI-based applications, with the goal of developing a platform with high communications and processing capabilities, as well as the use of standardized open protocols and data models that will allow resource consumption assessment and traceability for food industry processes. The project will be submitted under the call HE-CL4-DIGITAL-EMERGING-01-09: AI, Data and Robotics for the Green Deal and will target the non-robotic outcome. Currently, two pilots have been selected for validating the CLARUS solution. The first pilot focuses on the production of the frozen food, where energy and water consumption can be reduced using AI and data technologies. The other pilot focuses on the meat by-product production where the aim is to reduce the energy and maintain the quality of the products by optimizing the logistics of the by-products arrival. CLARUS ambitions include not only contributing to resource and logistic optimization methods through the two pilot solutions, but also making a more general contribution through the creation of a Green Deal Index (GDI).

Keywords: sustainability environmental impact assessment green deal food processing natural resource consumption data driven architectures
CLOUD Doctoral Network (CLOUD-DOC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Switzerland,Finland,Sweden,Austria,Cyprus,Estonia,United States
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 2789547.43
EU funding (EUR): 2673691.2
Participants: 21
Project status: SIGNED

CLOUD-DOC is to establish a network of early stage researchers (ESRs, all PhD students) at 12 institutions across Europe (10 EU-funded). The role of aerosol nucleation for atmospheric aerosol, clouds and climate is investigated. The focus of investigations will be to study under well-controlled laboratory conditions the oxidation chemistry, aerosol nucleation and growth processes that are responsible for aerosol particle formation in cold regions of the atmosphere: a) Arctic environments, b) the upper troposphere above the Asian monsoon region, c) the upper troposphere above tropical rain forests, and d) the Southern Ocean. The major research activity of the network will be two sets of joint experiments carried out at the CLOUD aerosol chamber at CERN to which all ESRs contribute. At the CLOUD chamber nucleation experiments are performed at an unprecedented level of precision and completeness using highly innovative instrumentation. A well-structured research and training plan is set up for every ESR as well as a comprehensive, quality-controlled supervision. A high-quality PhD training is arranged. The ESRs are brought together for network training events such as summer schools and workshops for integral data analysis. Courses by world-leading experts are taught spanning from general atmospheric aerosol chemistry and physics to specialized sessions including the role of aerosol for clouds, climate and also health. The summer schools and workshops are specifically tailored to the needs of the trainees. Transferable skills training includes courses on scientific writing, presentation skills, interaction with media, entrepreneurship, IPR, management, gender dimension and diversity in science, and good scientific conduct. The partners from the private sector (1 beneficiary, 4 partners) are closely integrated in the action.

Keywords: aerosol nucleation,new particle formation,aerosol cloud interaction,mass spectrometry,oxidation chemistry,charge effects,aerosol chamber studies
Critical infrastructure High accuracy and Robustness increase Integrated Synchronization Solutions (CHRISS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: EU Space
Destination: EU Space
Action type: Innovation actions
Countries involved: Romania,Poland,Austria,Greece
Call: EGNSS applications for Safety and Crisis management (HORIZON-EUSPA-2021-SPACE, 2021)
Start date: 2022-11-01
End date: 2026-04-30
Duration (months): 42.0
Total project cost (EUR): 3102875.0
EU funding (EUR): 2311699.0
Participants: 5
Project status: SIGNED

Critical infrastructure, such as telecommunications networks, requires GNSS based time reference to enable their proper functioning over a large area. Especially emerging telecommunications applications such as 5G or Time Division Duplex require a highly accurate and secure timing distribution. Failure of the time distribution service can lead to failure of critical infrastructure, resulting in blackouts or failure of the telecommunications network with damages exceeding the billion € for whole economies as well as severe safety and security risks for the general public. From the very nature of the GNSS systems, they are vulnerable to external, independent, and arbitrary radio interferences, jamming and spoofing. Consequently, the time synchronization may be interrupted or falsified, causing the real danger of time reference outage or alteration of the telecom network time reference. Therefore, finding approaches for detecting and mitigating radio interferences, jamming, and spoofing attacks is a critical issue for the security of telecom networks. Moreover, critical infrastructure requires safety layers, ensuring protection and integrity in the communication between nodes and terminals in the network (e.g., time synchronisation at the base stations of the telecommunications networks). The emerging technology of blockchain-based verification, identification and coding has been proven multiple times to be the future of information exchange applications. In the presented initiative, the "Critical infrastructure High accuracy and Robustness increase Integrated Synchronization Solutions – CHRISS will demonstrate first on the market, an integrated into one device, Galileo based timing distribution and synchronization solution enabling increased resilience to GNSS signals interference, jamming, spoofing and cyber-attack on fiber-optics distribution layer resulting in increased time distribution service availability, accuracy and reliability.

Keywords: gnss,galileo,gnss ins tight coupling,jamming detection and mitigation,spoofing detection,ossma,blockchain,critical infrastructure,5g networks,high accuracy synchronization,fpga,white rabbit
Privacy-Preserving Large-Scale Computation: Foundations and Applications (SCALE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1496711.0
EU funding (EUR): 1496711.0
Participants: 1
Project status: SIGNED

In In the era of exponential growth in available data, privacy and security have become paramount concerns for a wide range of domains, including healthcare, financial services, and many more. Classical tools developed in the cryptography community, e.g., the ability to perform computation on encrypted data without revealing the underlying information, could have the potential to address these challenges. However, most results do not fit modern large-scale distributed settings due to communication and storage limitations. A recent line of work attempts to bridge this gap, yet, existing solutions are still highly unsatisfactory since they assume either strong trusted setup assumptions, rely on strong and non-standard computational assumptions, or they are extremely theoretical. This research proposal aims to overcome the above drawbacks and systematically identify and design secure computation tools that can be effectively used within modern large-scale applications. To this end, we will address three main challenges: (1) understand and design distributed large-scale building blocks (such as broadcast protocols), (2) equip large-scale algorithms with privacy guarantees, and (3) increase the usability and practical usefulness of privacy-preserving tools in large-scale settings. A successful execution of the proposed research will capitalize on and develop new ideas in three key areas: cryptography, distributed computing, and algorithms. This research holds immense potential for applications in various domains. For instance, it could enable secure analysis of patient data across healthcare providers, improving diagnosis and treatment planning while preserving privacy. Similarly, in financial services, it could revolutionize fraud detection by collaborative analysis without compromising customer confidentiality. Ultimately, this research's goal is to design novel methods for privacy-preserving data processing, allowing new applications benefiting society as a whole.

Keywords: secure computation,distributed large scale algorithms
Globalisation, Europe and Multilateralism : Democratic Institutions, the rise of Alternative MOdels and mounting Normative Dissensus (GEM-DIAMOND)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,Italy,Netherlands,Denmark,Romania,France,Switzerland,United Kingdom,Japan,Canada,Brazil
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 3993645.6
EU funding (EUR): 3993645.6
Participants: 18
Project status: SIGNED

GEM-DIAMOND's agenda speaks to a cross-section of the Commission's political priorities for 2019-2024, most notably its push for renewed European democratic practices. As part of a wider ongoing research programme on Globalisation, Europe & Multilateralism, the project will delve into the impact of EU instruments on Democratic Institutions, the rise of Alternative MOdels, and present-day mounting Dissensus driven by internal contestation and external competition. Scientifically, the project will result in research and training outputs that will be of direct benefit in terms of improved citizens’ knowledge and democratic practices. Expected innovations produced by the 15 early career Researchers are anchored in: (1) an original conceptual understanding of 'dissensus'; (2) a unique form of interdisciplinary and methodological coherence; and (3) new empirical findings assessing the shifting efficiency and legitimacy of EU instruments. Educationally, the project offers an integrated training curriculum that will foster excellent research, further structure Ph.D. training at the European level, and help set new global standards in the field. The proposed Consortium is uniquely positioned to provide high-quality accredited degrees given that its members have decades of experience in the field and together have awarded over 50 double doctoral degrees. Societally, its Dissemination, Exploitation & Communication efforts will have a sustainable impact on the European Research (ERA) and Higher Education (EHEA) Areas rooted in its innovative practices and original research. The project will boost the career prospects of 15 researchers, promote innovative research practices standards with Open Science, and encourage innovative democratic practices through citizen science platforms hosted across Europe with an eye on ensuring all findings are readily available and directly exploitable. This will strengthen the prospects of civic participation and liberal democracy in the EU.

Keywords: dissensus,liberal democracy,rule of law,autocratization,democratic transition regression,eu governance,content analysis,discourse analysis,network analysis,process tracing,norms and values
Ultrafast physics in 2D halide perovskites for applications in optoelectronic devices (ULTRA-2DPK)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: CLOSED

ULTRA-2DPK aims to elucidate the fundamental limitations in the power conversion efficiencies (PCEs) of two-dimensional (2D) halide perovskites (PKs), guide the optimization of 2DPK and 2DPK/3DPK solar cell devices, and further promote their development for industrial applications. The increasing demand for clean energy technologies in Europe dictates the search for optoelectronic devices with reduced fabrication costs and high PCEs. 2DPKs provide promising pathways for developing stable next-generation optoelectronics, including solar cells, light-emitting diodes, and lasing devices. In principle, understanding the physical mechanisms underpinning the transient electron flows and atomic motion in 2DPK-based devices can lead to unprecedented improvements in their PCEs. To this aim, experiments based on ultrafast pump-probe spectroscopy are making excellent progress. However, computational strategies to interpret the complex nonequilibrium phenomena manifested in this type of measurements are still lacking. In this fellowship, a novel first-principles methodology, that takes entirely into account electron-phonon and anharmonic dynamics will be developed. The recent advances in electronic structure and many-body theory approaches will be combined to study thermal equilibrium and nonequilibrium optoelectronic properties of 2DPKs with increasing layer thickness. ULTRA-2DPK also focuses on the transfer of knowledge of the experienced researcher in finite-temperature many-body approaches to the host institute, as well as the enhancement of his soft and research skills that will enable him to become a leading figure in his field. The objectives of the present project match perfectly with the European Union targets of a sustainable solar energy ecosystem, as well as the development of modern and low-cost optoelectronic technologies.

Keywords: perovskites,hybrid 2d halide perovskites,nonequilibrium dynamics,electron phonon coupling,ultrafast pump probe spectroscopy,density functional theory,diffuse scattering,phonons
Unlocking Hidden History: The Sami in Swedish Farming Areas (SESAME)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1234258.75
EU funding (EUR): 1234258.0
Participants: 1
Project status: SIGNED

The Sami, the indigenous population of Sweden, Norway, Finland, and parts of Russia, are usually perceived as a reindeer-herding, nomadic people living in barren mountains and forests. However, the Sami have also for a long time been a part of farming societies dominated by other ethnicities. Despite some research on the “Parish Sami” of Central Sweden, this part of rural history is generally ignored. The SESAME project aims to unlock hidden history and deliver the first comprehensive study of the Sami living in farming areas before 1900 AD, with a focus on Sami agency without ignoring the importance of external factors. More specifically, SESAME will: – Provide an extensive overview of the Sami population of farming areas. – Redefine the historical geography of the Sami. – Clarify the dynamics and drivers of migration. – Develop methods to locate and investigate Sami dwelling sites. – Assess the ethnic identity of individuals and describe processes of acculturation and assimilation. – Map connections between the Sami populations of Sweden, Norway, and Finland. – Provide a comprehensive synthesis on the role of Sami in Fennoscandian farming society. The objectives of SESAME will be achieved through traditional historical research combined with linguistic and archaeological studies, as well as remote analysis, geographical information systems and methods of forest history. The project includes extensive cooperation with other interested parties and the creation of a network across Fennoscandia. The project team will consist of a PI with longtime experience of most of the sources and methods included, and two postdocs with complementary competencies. The SESAME project will lay a solid foundation for future research, both on Sami and on other indigenous populations and on marginal groups, and provide a truer image of the rural history of Fennoscandia, where the part played by the Sami finally receives the recognition it deserves.

Keywords: sami history