Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Prevention and Remediation of Insulin Multimorbidity in Europe (PRIME)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Spain,Italy,Germany,Belgium,Norway,Hungary,France,Netherlands,Netherlands,Netherlands,Netherlands,Denmark
Call: Understanding causative mechanisms in co- and multimorbidities combining mental and non-mental disorders (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 6000001.0
EU funding (EUR): 6000000.0
Participants: 23
Project status: SIGNED

PRIME introduces the novel concept of insulin signalling as a key mechanism underlying the multimorbidity of major mental and somatic illnesses. It is well known that aberrant insulin signalling causes high health and socioeconomic burden through its role in diabetes, metabolic syndrome, and obesity. We posit that the impact of ‘insulinopathies’ is still largely underestimated, since insulin multimorbidity also extends to the brain, where altered insulin signalling appears to be implicated in dementias such as Alzheimer disease and – based on our pilot work - in mental illnesses characterized by compulsivity, especially obsessive compulsive disorder and autism. We therefore further posit that insulin multimorbidity evolves throughout life, necessitating a lifespan approach. PRIME brings together a multidisciplinary team to (1) extend our understanding of insulin multimorbidity across the lifespan, (2) understand the causal mechanisms linking somatic and mental insulin-related illnesses, (3) develop tools for early diagnosis, improved clinical care, and prevention of insulin-related lifespan multimorbidity. We will leverage the world’s largest registry, clinical cohort, and population data sets to identify and validate new insulinopathies. Through an interdisciplinary battery of innovative approaches, we will clarify the causal mechanisms linking peripheral and central insulin signalling to body-brain comorbidity, integrating across animal models and studies in humans from molecule to cell, brain, cognition, and behaviour. Our prior evidence enables PRIME to bring the new knowledge to society, based on e.g. repurposing medication and lifestyle interventions (diet/exercise monitored by mHealth assessment), identifying and validating novel drug targets, developing and testing candidate biomarkers, and by improving existing medical guidelines and policy. Furthermore, educational approaches to inform clinicians, patients, and general public will be developed.

Keywords: insulin,diabetes type 2,obesity,metabolic syndrome,dementia,alzheimer,compulsivity,autism,exercise,diet,medication,interdisciplinary,ipsc neuron,mouse model,gene
Resilience of Coastal Human-Environment Systems (CHES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-27
End date: 2022-09-12
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Coastal cities face an increasing threat from storms due to the growing coastal populations and the intensifying storms under global warming. Coastal ecosystems can significantly reduce catastrophic damage from storms; however, existing risk assessments for coastal cities either do not include this crucial factor or do not consider future ecosystem changes. The proposed project, Resilience of Coastal Human-Environment Systems, CHES, will provide a holistic view of coastal environment resilience against storms under climate change by accounting for both the human and ecosystem elements. This work will quantify the protective effect of coastal ecosystems, forecast the future ecosystem conditions, and estimate the resilience of the coupled human-environment systems under different coastal urban development and climate scenarios. This project will greatly advance our understanding of the vulnerability of coastal human-environment systems to storms and the value of coastal ecosystems in storm protection, contributing to the development of sustainable coastal management plans coping with climate change.

Keywords: storms,coastal city,coastal ecosystem,climate change
Harnessing the innate and adaptive immune system with targeted neoantigen based cancer vaccines (SPLITVAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Immunotherapy for cancer has recently shown great clinical potential. However, only small percentages of patients do benefit from these therapies. The dual objective of the proposal is to understand and harness the immune system in vivo to develop truly personalized (individualized) anti-cancer treatments and to develop powerful bioconjugation technologies to generate new and better biotherapeutics. The project objectives will be achieved through the combination of ProteoDesign’s site-specific bioconjugation technology, with recent advances in the field of immuno-oncology, particularly the importance of tumor specific mutations (neoantigens), as drivers of anti-tumor immunity. The therapeutic candidates that will be obtained as a result of the project are personalized and have the potential to treat cancer at the individual level. These therapies are based on the mutational landscape of any given tumor, and so they could be applied to multiple cancer indications. The proposal will face specific challenges regarding the development of complex personalized bio therapeutics. The project will be carried out through the collaboration of Dr. Vanhooren and Barcelona based biotech ProteoDesign. Dr. Vanhooren has extensive know-how and experience in the pre-clinical development of biologic-based drugs, and ProteoDesign has a proprietary technology for the discovery and development of new therapeutic bioconjugates. Through the present proposal bidirectional knowledge transfer will take place between the fellow and the host, thus enhancing know-how and skills on both sides. Dr. Vanhooren will be focused on leading the project, setting and adapting objectives, designing experiments, supervising the team and analyzing results. During the project and through a specific plan, ProteoDesign will provide Dr. Vanhooren experience and knowledge in key areas of biotechnology and pharma industries, as well as senior management, to allow her to grow into high responsibility positions.

Keywords: cancer patients,therapeutic anti tumour activity,immune modulators,cell therapy,anti cancer treatments,proteins,antibodies
Electrochemistry of All-solid-state-battery Processes using Operando Electron Microscopy (Electroscopy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

All-solid-state batteries(ASSB) enabled by electrochemically stable solid electrolytes represent a promising alternative to the conventional lithium batteries with liquid electrolytes which jeopardize battery safety. However, the complex charge transfer at solid-solid interfaces greatly limits the electrochemical performance of ASSB. Therefore, a detailed understanding of how the morphology, structure and chemical composition changes at the electrode-electrolyte interfaces and within the solid electrolyte particles and/or across grain boundaries on battery cycling is urgently needed. In this project, I will utilize operando transmission electron microscopy(TEM) and scanning electron microscopy(SEM), to visualize the morphological, structural and chemical changes across electrode-electrolyte and electrolyte-electrolyte interfaces during battery cycling to develop new insights into ion transfer mechanisms at the atomic scale. For this, utilizing one of the best TEM facilities in the world including the expertise of TEM specialists and availability of sophisticated TEM specimen holders at the Ernst Ruska-Centre in Forschungszentrum Jülich, with state-of-the-art battery materials and battery engineering at Imperial College London and my expertise in designing and performing operando TEM battery studies, I will construct all-solid-state micro-batteries inside TEM and visualize morphological, structural and chemical changes at battery interfaces during (de)lithiation and compare these with that of liquid electrolytes to determine the best battery architecture. To evaluate how such nanoscale processes impact the performance of lab-scale ASSB batteries, SEM-based cells will be employed. The understanding of interfacial processes that dictate the potential of ASSB and new strategies to improve the battery performance developed from this project will be disseminated to a wide range of audience including battery industries, to advance ASSB technology for sustainable future.

Keywords: all solid state battery,operando,transmission electron microscope,scanning electron microscope
Resource Efficient Production Route for Rare Earth Magnets (REProMag)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Austria,Austria,Germany,Germany,Germany,Austria,Austria,Germany,Germany,Slovenia,France,United Kingdom,United Kingdom
Call: Manufacturing processes for complex structures and geometries with efficient use of material (H2020-FoF-2014, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 5726365.0
EU funding (EUR): 5726365.0
Participants: 15
Project status: CLOSED

The overall objective of the REProMag project is to develop and validate an innovative, resource-efficient manufacturing route (SDS process) for Rare Earth magnets that allows for the economically efficient production of net-shape magnetic parts with complex structures and geometries, while being 100% waste-free along the whole manufacturing chain. The new Shaping, Debinding and Sintering (SDS) process for Rare Earth magnets is an innovative automated manufacturing route to realise complex 3D- and multilayered parts; resulting in a significant increase in the material efficiency of at least 30% during manufacturing; while at the same time allowing additional geometrical features such as threads, cooling channels, small laminations/segments (e.g. to increase the efficiency of electrical motors) and structural optimisations such as lightweight-structures or the joint-free realisation. As part of the project, the possibility to produce hybrid parts such as an improved moving-coil transducer for headphones, loudspeakers and microphones will be evaluated. The SDS process allows a new level of sustainability in production, as the energy efficiency along the whole manufacturing chain can be increased by more than 30% when compared to conventional production routes. Moreover, the used raw material is 100% recycled and can be again recycled in the same way at the end of the lifetime of the products. In short, the innovative REProMag SDS process has the potential to manufacture complex structures of high quality and productivity with minimum use of material and energy, resulting in significant economic advantages compared to conventional manufacturing. The REProMag project is a highly innovative combination of applied research, technology development and integration, resulting in small-scale prototypes and a closely connected demonstration activity clearly showing the technical feasibility of the REProMag SDS processing route in a near to operational environment.

Keywords: additive manufacturing,metal injection moulding,hybrid materials,debinding and sintering,rare earth magnets
Robust Control, State Estimation and Disturbance Compensation for Highly Dynamic Environmental Mechatronic Systems (CLOVER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria,Germany,Germany,Germany,Norway,Belgium,Belgium,Netherlands,United Kingdom,United Kingdom,Japan,Mexico
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 769500.0
EU funding (EUR): 684000.0
Participants: 14
Project status: CLOSED

The main goal of the CLOVER project is to offer a novel methodology in an environmental mechatronic control system design relying on multidisciplinary knowledge. This methodology should allow aspects to be taken into account, such as controller robustness, indirect measurement of system states and parameters, and disturbances attenuation on the stage of establishing controller architecture. In addition, methods for tuning the control algorithms will be developed and based on the solution of optimization task considering control priorities, such as environment friendliness and energy efficiency. The implementation of the project CLOVER is based on intensive staff exchange that will lead to collaborative research and training between universities and industrial organizations from Germany, Austria, Belgium, Norway, UK, Mexico, and Japan. To guarantee a strong focus of the project activities on real-world problems, the CLOVER concept is based on the R&D and training in three interfacing topics: “Mechatronic chassis systems of electric vehicles”, “Mechatronic-based grid-interconnection circuitry”, and “Offshore mechatronics”, which will identify and facilitate collaborative learning and production of innovative knowledge. The CLOVER objectives will be achieved through intensive networking measures covering knowledge transfer and experience sharing between participants from academic and non-academic sectors, and professional advancement of the consortium members through intersectoral and international collaboration and secondments. In this regard, the CLOVER project is fully consistent with the targets of H2020-MSCA-RISE programme and will provide excellent opportunities for personal career development of participating staff and will lead to the creation of a strong European and international research group to create new environmental mechatronic systems.

Keywords: mechatronics,hardware in the loop,electric vehicles,offshore engineering
INTEGRATIVE VISION SYSTEM OF ON-BOARD SORTING OF EXPLOITED STOCKS AND REAL-TIME COMMUNICATION WITH LAND (SEASCANN)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: SME instrument
Countries involved: Iceland
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-04-30
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

SKAGINN is an Icelandic innovative company with <170 staff that was created in 1998. This leading SME supplies worldwide a high variety of own-developed processing equipment in the food industry. The novel SEASCANN we present here is a cutting-edge technology of pre-processing based on a vision system to classify catches on board depending on the species, size and commercial value. The system is two-folded integrated, (i) vision system, with a feeder, a vision unit, a separator and a batcher, and (ii) GPS connectivity system that transfers data to the Cloud in real time. This allows land operators to track catches by each boat immediately, and better plan marketing and sales. The system will make data available also to fishery inspectors and authorities so individual quotas can be monitored in real time, without any delay. SEASCANN improves by 35-65% the efficiency of conventional fishing sorting methods, and 10-15% of time saving for commercialization compared to current technology, due to real-time connectivity between on-board and land-based personnel. Thus, our disruptive innovation will allow fisheries' value chain to move forward maximum levels of efficiency by lowering production costs and optimizing market management. As a whole, SEASCANN will get results 15-25% more efficient than conventional methods of sorting and communication from boat to land. Real-time assessment and surveillance of fish stock from on-board would provide a closer interaction within the fishery industry, with a better plan marketing and sales, and also between fishery sector and authorities, with the possibility of adjusting managing fishery decisions. SKAGINN forecasts €106 million cumulative revenues for the period 2020-2022, and staff will be increased by 35 people. Profitability ratios in 2020, 2021 and 2022 are 22, 27 and 30% respectively, to be incremented up to 45% by 2025.

Keywords: vision system,fisheries,fish sorting,on board,remote communication,fishing quotas,fish processing
The Nexus: an experimental system to study marine larval dispersal (Nexus)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Australia,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-02-18
End date: 2020-05-14
Duration (months): 36.0
Total project cost (EUR): 276107.4
EU funding (EUR): 276107.4
Participants: 3
Project status: CLOSED

Dispersal is a fundamental trait for the ecological and evolutionary dynamics of any given species. In marine systems, the primary means of connectivity among fragmented habitats is pelagic larval dispersal (LD). Due to the inherent difficulty of tracking minute larvae in the ocean, we are still lacking critical insights into the internal and external causes and consequences of LD. Here, we propose the development of an experimental infrastructure, the Nexus, composed of 25 interconnected larval rearing/settlement tanks, designed to study larval movements as a model of dispersal. We aim to use the Nexus framework to investigate central questions in LD theory that, up to this point, have been difficult to assess: (1) Do marine organisms exhibit condition-dependent dispersal strategies? (2) If so, how does the interaction of phenotype and environment affect dispersal behaviours (context-dependence)? (3) How will climate change affect condition- and context-dependent dispersal in offspring via parental effects? These are timely issues to address, as a better understanding of the underlying mechanisms regulating LD will help predict species’ responses to rapid environmental change. The intended framework will facilitate the holistic assessment and controlled manipulation of the entire LD process, from the natal environment to post-settlement selection, thereby paving the way for novel research avenues in aquatic dispersal ecology. Each tank in the network can independently be controlled for the type of habitat it provides and corridors can flexibly be opened, closed or made directionally permeable. The versatility of the Nexus offers a high degree of experimental flexibility and control to address key issues in spatial meta-population ecology.

Keywords: metapopulation,connectivity,climate change,phenotype,parental effects
KOBOT – a VOice-responsive RObot for the COnstruction floor (VOROCO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

KOBOTS is a spin-out from a craftsman company in 2018 to at-tract competences and investments to fuel our ambition of disrupting robot adoption at the building construction sites. 2/3 of working hours in construction industry are not spend on value added work. Traditional ways of working keep a considerable number of “manual” tasks at the construction site: As example, 80% of all materials delivered to a site needs further processing like cutting meaning that craftsmen will spend up to 50% of their total work time on low-value tasks such as measurement and cutting boards. The derived productivity loss of 18M construction workers in the EU tops €120Bn. We have invented KOBOT, a voice-responsive robot platform, which can be used on the construction site to automate up to 75% of time spend on routine cutting tasks. The robot is voice-responsive, flexible and transportable – it requires little training, leverages the craftmen know-how and investment in power tools. KOBOT also improves working environment (removing craftsmen from direct exposure to noise, dust and vibration) and safety (remove craftsmen from direct exposure to saw and heavy lifts of horizontally placed boards). The business opportunity is vast. Our Total Addressable Market (TAM) is €43.2Bn. We aim to rapidly penetrate this market by introducing a far superior technology. Through our scalable dis-tributor-based business model, we expect to capture a market share of 3,7% (of Serviceable Available Market), a turnover of €16.3M, EBIT of €3.2M and additional employment of 45 people by 2025. This SME-Instrument Phase 1 project VOROCO will allow us to 1) strengthen our IP management strategy, 2) develop a clear go-to-market business plan, and 3) gather further documentation of productivity gains and other tangible benefits. Output from this project will set the bases for validating our upcoming KOBOTS MVP, which we will market ready with a SME-Instrument Phase 2 project.

Keywords: voice responsive,voice control platform,collaborative systems,cloud computing,construction,engineering,municipal and structural engineering,automation and control systems