Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nanofiber based drug delivery for surgical therapy of adult and paediatric solid tumours (RELEASE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Spain
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cebiotex is a company founded by medical business entrepreneurs plus experts from the biomedical nano-fibre plus oncology sectors. With experts from a world leading hospital in cancer treatment(Sant Joan de Déu) and researchers from the Universitat Politecnica de Catalunya, we have been steadily developing our technology and single minded vision for several years. Our patented process allows for a unique method for depositing of active agents between nano-fibres. The resultant flexible, biodegradable nano-gauze will be able to radically improve treatments across multiple fields. Our first product line uses the highly potent and promising anti-cancer drug, SN-38. Until now, the low solubility of a drug such as SN-38 has withheld its adoption because standard drug delivery mechanisms fail. We turn the problem on its head, using our proprietary gauze we hold the active agent in place next to the treatment area, taking advantage of the low solubility of such drugs to provide constant high dosage to targeted cells over 4 weeks. With a focus on this initial cancer cell therapy control drug, we have a vision to use this as a spearhead to firmly plant ourselves in the European medical biotech sector. We request targeted SME Instrument funding in order to fully prepare the commercial groundwork for our vision to become a leading drug delivery platform organisation and to finalise plans to move our first product from pre-clinical to phase I/II trials. By challenging all of our assumptions we wish to confirm our predictions for a solid business, solid employment growth and a new nano-tech drug development specialism in Europe.

Keywords: drug delivery,nanofibers,nanotechnology,sarcoma,cancer,breast cancer,colonorectal cancer,improved patient treatment,health care costs reduction
2D Oxide and van der Waals layered devices (OXWALD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Two-dimensional (2D) Van der Waals (VdW) materials have started a new era in the physics and chemistry of materials full of exciting challenges in fundamental science and also holding impressive technological promises connected to their atomic scale thickness. However, electrons in current 2D materials, with graphene being the most representative example, do not “feel” each other and their electronic properties are interpreted within single particle models. Correlated 3d transition metal oxides (CCO) are prototype correlated materials where the unscreened Coulomb repulsion between electrons in narrow 3d bands gives rise to a delicate entanglement between electronic attributes: charge, orbital and spin. Their complex interactions is at the bottom of non-trivial entanglements responsible for a wide variety of electronic ground states (superconductivity, multiferroicity, spin or charge order, quantum magnets, etc). Moreover, these electronic phases can be manipulated by external stimuli (electric field, light, magnetic field etc) giving rise to a plethora of coupled responses. Typically these CCOs present broader range of functionalities than conventional 2D materials. In OXWALD the fellow Victor Rouco, will search for new synthesis strategies of 2D CCO freestanding monolayers, and their combinations in multifunctional heterostructures with conventional VdW materials. The main goal will be to imprint electron correlated groundstates into the one-electron states of vdW materials. This fellowship will be carried out at the Universidad Complutense de Madrid (UCM) under the supervision of Prof. Jacobo Santamaria with a secondment at the Institute of Materials Research ICMM-CSIC also in Madrid.

Keywords: complex correlated oxides,van der waals,quantum materials
Green finance for sustainable farming in Europe (SOLARFARM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain,Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-07-01
End date: 2018-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Photovoltaic systems for irrigation (PVI) can reduce the energy costs of agriculture by more than 75% while saving up to 30% of its water consumption. There are proven PVI technologies available but investments exceeding € 24 bn are required to install the systems on the European farms. Affordable capital can be obtained for PVI projects from institutional investors if they are “packaged” in suitable investment instruments like green bonds. We aim to provide the technological and financial solutions for PVI projects that allow them to be financed directly by institutional investor, reducing drastically the costs and uncertainty for farmers. The web-based solution is the result of in-house technological developments for PVI and a tailored business model including a set of standardized contracts, technical specifications and management protocols as well as the human resources and infrastructure that allow for the creation of pools of PVI ready to attract institutional investors. Importantly, by introducing the necessary standards and tracking the quality and performance of the assets with a specific methodology, we will ensure that the resulting investment instruments are in full compliance with the new requirements of the European Capital Market Union. Furthermore, the use of blockchain-based smart contracts has the potential to drastically reduce the costs and time required to assess and validate collateralized assets, creating a remarkable business opportunity for our companies

Keywords: renewable energy,sustainable farming,green bonds,blockchain,fintech,water management,institutional investors,solar irrigation,energy management,inclusive finances,solar securitization
Imaging the Force of Cancer (FORCE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Australia,Germany,Switzerland,Switzerland,Norway,France,France,France,France,Netherlands,United States,United Kingdom,United Kingdom,United Kingdom
Call: Development of new diagnostic tools and technologies: in vivo medical imaging technologies (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2021-07-31
Duration (months): 67.0
Total project cost (EUR): 7418116.25
EU funding (EUR): 5812631.25
Participants: 20
Project status: CLOSED

Cancer is the second leading cause of mortality in EU member states with ~90% of all cancer deaths caused by metastatic spread. Despite its significance, measuring metastatic potential as well as potential indicators of therapy efficacy remain unmet clinical challenges. Recently, it has been demonstrated in vitro, that aggressive metastatic cells pull on their surroundings suggesting that metastatic potential could be gauged by measuring the forces exert by tumours. Furthermore, many solid tumours show a significantly increased interstitial fluid pressure (IFP) which prevents the efficient uptake of therapeutic agents. As a result, a reduction in IFP is recognized as a hallmark of therapeutic efficacy. Currently, there is no non-invasive modality that can directly image these forces in vivo. Our objective is the non-invasive measurement of both IFP within tumours as well as the forces they exert on their surrounding environment. This will be used to predict a tumour’s metastatic potential and importantly, changes in these forces will be used to predict the therapeutic efficacy of drug therapy. To attain this goal, the biomechanical properties of the tumour and its neighbouring tissue will be measured via MR-elastography at various measured deformation states. Resultant images will be used to reconstruct images of the internal and external forces acting on the tumour. We call this novel imaging modality Magnetic Resonance Force (MRF) imaging . We will calibrate MRF via cell cultures and pre-clinical models, and then test the method in breast, liver, and brain cancer patients. Thereby, we will investigate whether MRF data can predict metastatic spread and measure IFP in patients. We will also investigate the potential to non-invasively modulate the force environment of cancer cells via externally applied shear forces with the aim of impacting cell motility and proliferation. This can provide novel mechanism for anticancer therapeutic agents via mechanotransduction.

Keywords: interstitial fluid pressure,metastatic potential,drug uptake,mr elastography,non linear tissue mechanics
EMPOWERING a reduction in use of conventionally fueled vehicles using Positive Policy Measures. (EMPOWER)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Türkiye,Finland,Sweden,Netherlands,Netherlands,Netherlands,Kenya,United Kingdom
Call: Transforming the use of conventionally fuelled vehicles in urban areas (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 36.0
Total project cost (EUR): 4898621.0
EU funding (EUR): 4898621.0
Participants: 12
Project status: CLOSED

The main objective of EMPOWER is to substantially reduce the use of conventionally fueled vehicles (CFV) in cities by influencing the mobility behaviour of CFV drivers and users towards fundamental change. To achieve this objective EMPOWER will create a set of tools for industry, policy makers and employers. These will empower them beyond the lifespan of this project to understand, help choose and successfully implement ‘positive’ evidence-based and cost-effective policy interventions, based on new and innovative mobility services, and in the context of already existing infrastructure, policy and measures. EMPOWER will reduce the use of CFV by: shifting trips to other modes/other vehicle types, promoting sharing and self-organisation and reducing demand overall e.g. through remote access to services. Undesirable impacts from CFV use will be reduced by: shifting CFV use to outside peak times and diversions to avoid particular areas/routes. The research will be multidisciplinary and involve: social science research with the public, 4 living lab experiments and 7 City demonstrators which will be chosen through an open 'bidding' process. The EMPOWER concept will be used in practice by: City stakeholders being able (through a software tool) to choose positive policy options based on their expected impacts and deliver incentives and social network sharing schemes to individuals using software. The innovation outputs of EMPOWER include an EMPOWER Toolkit to support industry, policy makers and employers to understand, choose and implement positive policy interventions. The Toolkit includes: new mobility services to provide innovative positive policy measures, new evidence on behavioural responses and impacts from positive incentives, improved organisational models for successful implementation of positive policy measures and innovation in the evaluation methodology for new mobility services. We expect at least 1 million persons to be impacted by EMPOWER.

Keywords: social media,sharing and self organisation,organisational models
Self-Organising, Self-Managing Heterogeneous Cloud (CloudLightning)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Ireland,Ireland,Ireland,Norway,Greece,Greece,Romania,United Kingdom
Call: Advanced Cloud Infrastructures and Services (H2020-ICT-2014-1, 2014)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 3957050.0
EU funding (EUR): 3934425.0
Participants: 8
Project status: CLOSED

Currently cloud infrastructures are mostly homogeneous -- composed of a large number of machines of the same type -- centrally managed and made available to the end user using the three standard delivery models: Infrastructure-as-a-service (IaaS), Platform-as-a-Service (PaaS) and Software-as-a-Service (SaaS). As clouds increase in size and as machines of different types are added to the infrastructure in order to maximise performance and power efficiency, heterogeneous clouds are being created. However, exploiting different architectures such as graphics processing units, many integrated cores and data flow engines, poses significant challenges.To efficiently access heterogeneous resources and, at the same time, to exploit these resources to reduce application development effort, to make optimisations easier and to simplify service deployment requires a reevaluation of our approach to service delivery. The evolving complexity of the cloud ecosystem will eventually render traditional cloud management techniques ineffectual. Self-organisation and self-management are powerful techniques for managing complexity. Some of our initial simulation results using self organisation and self optimisation indicate that these can be used as the basis of a new cloud management and delivery model capable of efficiently dealing with issues that arise at scale. Our preliminary work has centred on promoting access to power efficient heterogeneous resources by shifting the deployment and optimization effort from the consumer to the software stack running on the cloud infrastructure. With CloudLightning, we propose to extend this work and to build a cloud management and delivery infrastructure based on these principles. Given the prohibitive expense associated with empirical experimentation on hyperscale cloud infrastructures, data gathered on our testbed will be used to simulate this infrastructure and to evaluate the self organisation approach in that context.

Keywords: self organisation,self optimisation,heterogeneous resources,graphics processing unit,many integrated core,data flow engine
Disruptive IoT solution for optimising the animal feed supply chain (INSYLO)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-05-01
End date: 2020-12-31
Duration (months): 32.0
Total project cost (EUR): 1435876.25
EU funding (EUR): 1005113.38
Participants: 1
Project status: CLOSED

Animal feed is produced by feed suppliers in feed mills, and distributed in bulk to different animal farms, where it is stored in silos. Feed has to be produced ad-hoc for each farmer, and delivered in 24-48h. Each feed supplier is the provider for several silos from several farms (the top 50 EU feed suppliers manage on average 7,500 silos each). They receive daily hundreds of refilling orders whose logistics have to be optimized in a short time. However, the lack of reliable and cost-effective solutions to remotely monitor the silo’s feed stock hinders the optimization: most farmers assess it manually, provoking (i) inaccurate measures (trucks over or under loaded) and (ii) uncertainty on the demand (feed suppliers cannot organize production cycles or the raw materials purchase based on a cost-effectiveness criteria). As a result, there is yearly losses of 500€ per silo (equivalent to 400M€ in the EU28). INSYLO turns the situation around and provides the sector with an accurate and cost-effective solution to monitor remotely the silos’ feed stock levels, forecast the feed demand and allow feed suppliers to optimize inventories, production batches, delivery routes and raw materials purchases. INSYLO is a smart service that combines hardware and software. Through our unique smart volumetric sensor, we obtain an accurate measure of the silos' feedstock levels at a very low cost (6.5 cheaper than competitors). Our IoT device can be installed in only 5 minutes and it is fully independent of the farm’s resources (off-grid, solar energy, own Internet connectivity). Furthermore, it is connected to our smart platform on the cloud, which leverages the power of Big Data and Artificial Intelligence to collect data from hundreds of thousands of silos and decide the right moment and quantity to restock each silo, optimising the whole feed supply chain. We will sell in the first five years more than 100,000 devices, capturing a market share of 2.13% of the 5M silos worldwide.

Keywords: smart farming,animal feed,supply chain optimisation,husbandry,livestock,big data,internet of things
Hyperfine splittings in muonic atoms and laser technology (HyperMu)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Switzerland,Switzerland
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-10-01
End date: 2024-03-31
Duration (months): 78.0
Total project cost (EUR): 1999926.0
EU funding (EUR): 1378994.75
Participants: 2
Project status: SIGNED

The proton radius extracted from the measurements of the 2S-2P energy splitting in muonic hydrogen (μp) has attracted great attention because of a 7σ discrepancy with the values extracted from electron scattering and hydrogen (H) spectroscopy. Hundreds of publications have been devoted to the so called “proton radius puzzle” ranging from studies of physics beyond the standard model, to reanalysis of electron scattering data, refinements of bound-state QED calculations, new theories describing the proton structure, and proposals for new scattering and H spectroscopy experiments. As next step, I plan two new (i.e., never before attempted) measurements: the ground-state hyperfine splitting (1S-HFS) in both μp and μ3He+ with 1 ppm relative accuracy by means of pulsed laser spectroscopy. From these measurements the nuclear-structure contributions (two-photon-exchange) can be extracted with a relative accuracy of 100 ppm which in turn can be used to extract the corresponding Zemach radii (with a relative accuracy of 0.1%) and polarizability contributions. The Zemach radii can provide magnetic radii when form-factor data or models are assumed. These radii are benchmarks for lattice QCD and few-nucleon theories. With the polarizability contribution they impact our models of the proton and of the 3He nucleus. Moreover, the μp measurement can be used to solve the discrepancy between the magnetic radii values as extracted from polarized and unpolarized electron scattering and to further test bound-state QED predictions of the 1S-HFS in H. These two experiments require a muon beam line, a target with an optical cavity, detector, and laser systems. As weak M1 transitions must be probed, large laser-pulse energies are needed, thus cutting-edge laser technologies (mainly thin-disk laser and parametric down-conversion) need to be developed. Laser schemes of potentially high industrial impact that I have just patented will be implemented and refined.
Integrated Network of Sleep-Optimizing Modules for Norm-Informed Adaptive Behavioural, Environmental And Therapeutic Internet Training (INSOMNIA BEAT IT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-05-01
End date: 2018-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Major depression is among the most prevalent and burdening health hazards. Our best chance to combat the pending global pandemic is to provide preventive interventions to identified people at risk. The strongest modifiable risk factor is insomnia. Insomnia can be ameliorated by its recommended treatment, cognitive behavioural therapy (CBT), which indeed improves depression outcomes. Current health infrastructures however cannot supply CBT for the ±10% of the population suffering from insomnia. Internet-based self-help could solve this bottleneck, but current implementations utilize only a fraction of the evidence-based effective intervention possibilities, are not equipped to support personalized approaches, and do not harness the potential to support large-scale research. The current PoC project will build an Integrated Network of Sleep-Optimizing Modules for Norm-Informed Adaptive Behavioural, Environmental And Therapeutic Internet Training (INSOMNIA BEAT IT) to solve these shortcomings and allow for the implementation of personally optimized combination of self help modules to promote health in general and to prevent depression in particular. It has a high potential for widespread marketing to health professionals and companies that may want to offer the platform to their employees to promote health and well-being.

Keywords: ehealth,depression,prevention,insomnia,internet,individual differences