Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Safe and natural UV skin protection (UVERA)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: Poland
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-10-01
End date: 2024-06-30
Duration (months): 45.0
Total project cost (EUR): 3561662.5
EU funding (EUR): 2493163.75
Participants: 1
Project status: SIGNED

UVera is a fusion of innovation and interdisciplinary approach to skin protection against the whole spectrum of UV sun radiation as well as anti-pollution factors like Blue Light. Our mission is to provide society with natural and safe UV protection products with no negative environmental impact on the planet. Regular synthetic chemical UV filters cause DNA damage and strong allergy reactions, can increase the risk of cancer developing as well as disrupt the endocrine system. What is more, they are responsible for destruction of coral reefs and marine ecosystem. There is a clear need for new safe and produced in natural way UV sunscreen filters. We provide the solution by offering to the cosmetic market single dominating UV protector. Our ecologically friendly novel compound is produced by specific species of cyanobacteria. It has great stability and uniquely wide photoprotection activity. And most important: it is safe to human body as well as natural environment. For the first time unique microorganisms which are occurring in natural environment are used to produce a natural UV-protection compound on industrial scale. The technology of production is humble and disruptive - based on bacteria natural farm harvesting, meaning no recombinant nor GMO, fueling with sun rays and CO2 and environmentally safe side products of O2 and nutritious biomass to be further used in natural cosmetics and ecological agriculture. UVera is a bridge between ideas and innovation, which was created out of interdisciplinary works of scientists and business developers. Our team brings together subject experts in technologies related to microbiological culturing, process design and engineering, scale-up of new technologies, and translation of innovative ideas into commercial products. The team has gathered market intelligence and comes with a strong network of industry leaders. We have expertise in commercialization of medical projects with successful exits and Mergers and Acquisitions.

Keywords: uv protection,sunscreen,uv filter,organic,ecologically friendly,eco friendly
Functional dissection of core spliceosomal mutations causing Retinitis Pigmentosa. (SpliceCore)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

More than 95% of human genes undergo pre-mRNA splicing, and alternative splicing of mRNA precursors represents a prevalent mode of gene regulation. Errors in this process are often the origin of of disorders. Most of splicing-related diseases are caused by perturbation in pre-mRNA transcripts which lead to their aberrant processing. Interestingly, a fraction of mutations affecting directly splicing factors, including core spliceosomal components, has been linked to a group of pathologies. Particularly intriguing are variants of the key spliceosomal subcomplex U4/5/6 tri-snRNP, associated with Retinitis Pigmentosa. Why these mutations lead to highly tissue-specific phenotypes, rather than general toxicity cause by a global block in splicing, remain unexplained. The proposed research aims to increase our understanding of the molecular mechanisms underlying the effects of these mutations and shed light on the basis of the disease. To functionally dissect these variants, I will combine spliceosomal network approaches (I) with genome-wide transcriptome analysis (II) and detailed biochemical and structural studies (III). Mechanistic insights derived from these analyses will help to identify transcripts that are predominantly sensitive to these mutations and that could be behind their pathogenic effects (IV). This work will allow us to better understand the function of key splicing factors, as well as the basis for their effects on splice site selection and their contributions to Retinitis Pigmentosa pathology.

Keywords: splicing,mutations,core splicosome
Metabolic Profiling of the Vaginal Microbiome for Reproductive Health (MUMVIP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-04-01
End date: 2020-12-31
Duration (months): 21.0
Total project cost (EUR): 149633.0
EU funding (EUR): 149633.0
Participants: 1
Project status: CLOSED

There is ever increasing evidence that the vaginal microbiome plays an important role in reproductive health. Studies have shown that dysbiotic states can culminate in bacterial vaginosis, urinary tract infections and premature birth. Although the microbiome is usually characterised by 16S rRNA sequencing, the methodology is time consuming and expensive. Here we describe the development of a desorption ionisation mass spectrometry (DESI-MS) based technique which characterises microbial community structures based upon metabolomic analysis. The technique has been successfully demonstrated for a range of applications and here we describe its commercial development as a diagnostic tool, firstly, for assessing the potential success rates of in vitro fertilisation treatments and, secondly, for stratifying patients at higher risk of pre-term birth. During the first 12 months of the project the technology will be assessed using a unique sample set collected as part of two longitudinal cohort studies. During the later stages a thorough market assessment will be performed to identify the addressable demand and to evaluate market competitors. It is envisioned that this information will allow an in depth business case, including our current intellectual property position, to be written, from which further funding can be obtained for the eventual creation of a spin out company.

Keywords: metabolomics,diagnostics,microbiome,reproductive health
Development of kinematic and muscle patterns in preterm infants (INFANTPATTERNS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-01
End date: 2022-11-30
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: CLOSED

The first weeks and months after birth are critical for early sensorimotor development, with brain injury at this time often resulting in the later development of long-term neurodisabilities such as cerebral palsy. Despite this, the evolution of control patterns in this phase of life has never been systematically studied, due to the technical difficulties associated with accurately measuring infant movements and motor commands. This project will thus: (i) measure for the first time the full body movements of preterm infants (using dedicated systems to accurately measure the force applied by the infants and their movement as well as high-density EMG); (ii) identify the infants' movement patterns and their evolution during this critical phase after birth. This ambitious project is feasible due to the extended expertise in human robotics of the supervisor at Imperial College London and the secondment with a strategic partner at the neonatal medicine department at Kings’ College London. This Marie Curie fellowship will give me a unique opportunity to create an innovative quantitative assessment and understanding of the developing motor function in infants, which has high potential for significant clinical and scientific impacts.

Keywords: human robotics,preterm infants,motion capture,high density emg
Hydrologic Extremes at the Global Scale: teleconnections, extreme-rich/poor periods, climate drivers and predictability (HEGS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Australia,France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-17
End date: 2022-05-16
Duration (months): 36.0
Total project cost (EUR): 281827.2
EU funding (EUR): 281827.2
Participants: 3
Project status: CLOSED

Hydrologic extremes (floods and intense precipitations) are among Earth’s most common natural hazards and cause considerable loss of life and economic damage. Despite this, some of their key characteristics are still poorly understood at the global scale. The IPCC thus reports “a lack of evidence and thus low confidence regarding the sign of trend in the magnitude and/or frequency of floods on a global scale”. More generally, the space-time variability of hydrologic extremes is yet to be thoroughly described at the global scale. As a striking illustration, the recent initiative “23 unsolved problems in Hydrology that would revolutionise research in the 21st century” of the International Association of Hydrological Sciences includes questions such as: are the characteristics of extreme hydrologic events changing and if so why? How do extremes around the world teleconnect with each other and with other factors? Why do extreme-rich/poor periods exist? It is vital to fill these knowledge gaps to inform design, safety and financial procedures and to improve hazard preparedness and response. The project’s ambition is hence to better understand the global space-time variability of hydrologic extremes, using a three-pillar research strategy based on methodological innovation, extensive data analysis and proof-of-concept case studies. The specific objectives are to: 1. Develop a statistical framework to describe the global-scale variability of extremes in relation to climate; 2. Analyse global precipitation/streamflow datasets with the aim of quantifying teleconnections, spatial clustering, trends and extreme-rich/poor periods, along with their climate drivers; 3. Explore practical applications such as global early warning systems allowing international disaster response organisations to trigger early actions. Successful completion of the project will deliver new tools to analyse extremes at the global scale and will hence contribute to more efficient risk management.

Keywords: hydrologic extremes,floods,precipitations,global scale,teleconnections,space time variability,climate variability,bayesian modelling,hidden variables,hazard management,seasonal forecasting
NEOdymium-Iron-Boron base materials, fabrication techniques and recycling solutions to HIghly REduce the consumption of Rare Earths in Permanent Magnets for Wind Energy Application (NEOHIRE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Spain,Germany,Spain,Belgium,United Kingdom,Japan
Call: Innovative and sustainable materials solutions for the substitution of critical raw materials in the electric power system (H2020-NMBP-2016-two-stage, 2016)
Start date: 2017-02-01
End date: 2020-01-31
Duration (months): 36.0
Total project cost (EUR): 4532638.75
EU funding (EUR): 4443888.75
Participants: 10
Project status: CLOSED

Regarding NdFeB PM technology for WT, it is still necessary to break through 3 important barriers: Strong dependence on China for supply and high price of REE present in PM, high difficulty of substitution of REE in PM, and technical and economic barriers that avoid establishing commercially viable, large-scale REE recycling framework. In this context, NEOHIRE main objective is to reduce the use of REE, and Co and Ga, in WTG. This objective is mainly achieved through the development of: a) New concept of bonded NdFeB magnets able to substitute the present state-of-the-art sintered magnets for WT, and b) New recycling techniques for these CRM from the future and current PM wastes. In this way, the EU external demand of REE and CRM for PM in WTG will be reduced in a 50%. The specific objectives are: i) To develop a new NdFeB material solution that reduces the use REE and CRM amount in PM for WTG (100% of HRE, 30% of LRE Nd/Pr, and 100% of CRM Co and Ga), ii) To increase the deliverable electric power in wind power electric generators from current 2.74 MW to 3.56 MW per 1Tn of REE owing to novel electric machine designs, iii) To research and develop two recycling processes to highly increase the CRM recycling rates in NdFeB PM wastes for sintered PM from current WT (increase from 0 to 70% the recovered Nd, separate 100% of Dy and recover 90% of Co) and novel Bonded NEOHIRE PM (recycling almost 95% of Nd), iv) To achieve an economic and technically feasible large-scale framework for NdFeB PM commercial recycling, and v) To ensure the economic and technical sustainability of NdFeB resin-bonded PM developed technologies. NEOHIRE will count on PM material RTD experts (CEIT, UOB), material recycling experts (UOB, KU LEUVEN), material characterisation RTD experts (CEIT, UPV, LBF), JP Powder manufacturer (AICHI), PM manufacturer (KOLEKTOR), LCA experts (UNIFI) and WT manufacturer (INDAR). AICHI (Japan) will be involved by providing advice and raw materials to the project.

Keywords: permanent magnets,sintered magnets,bonded magnets,neodinium,wind turbines,rare earth elements,dysprosium,wind turbine generator,wind power
Second Order nano-Oxide Nonlinear Disordered phOtonics (SECOONDO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

Despite the growing demand of simple and robust nonlinear optical devices, efficient optical conversion is still obtained by imposing stringent phase matching conditions on the nonlinear optical material (NLOM), critically increasing the fragility and the cost of nonlinear optics applications . The search for alternatives NLOMs with relaxed phase-matching conditions have attracted a large interest, but none of the mature alternatives is expected to satisfy market’s requirements of easy-fabrication, scalability and low-cost. Disordered NLOMs have shown the biggest potential in this direction, giving evidence of efficient and large-angle conversion without the need of phase-matching tuning. However, only few of the several opportunities provided by optical disorder has been exploited for nonlinear conversion due to materials and fabrication limitations. Therefore, the combination of multiple conversion mechanisms could generate unconventional and powerful phase matching mechanisms. SECOONDO aims at the realization of a new class of disordered NLOMs based on perovskite nanoparticles (nano-oxides) in which random phase-matching, light scattering and Mie resonances coexist, but are also independently controllable. We will explore a new physics in optical nonlinear conversion, which could open avenues to the realization of easy and efficient nonlinear optical device. The project takes inspiration from the complementary competences of the candidate in disordered photonics and of the supervisor in nonlinear nano-oxides generating new knowledge on both sides. The candidate will acquire new competences in nonlinear nano-optics and in material sciences, which combined to his past knowledge, will make his profile unique, ensuring independence and a strong future career.

Keywords: random media,light scattering,phase matching,mie resonances,perovskite,nanoparticles,nano oxides,solution processing
'A transregional and interdisciplinary study of the societal impact of the shipworm epidemic in the North Sea region in the eighteenth century' (SHIPWORM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-10-31
Duration (months): 26.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

This transregional and interdisciplinary research proposal analyses the impact of the shipworm epidemic on coastal societies along the North Sea in the eighteenth century. The shipworm is a mollusc that scavenges floating or submerged wood in a marine environment. Lodged in the wooden hulls of returning East Indiamen, the shipworm was brought to Europe around 1730. Within a few years the shipworm had destroyed man-made wooden structures all along the North Sea coast. North-Western Europe faced an ecological disaster; the Low Countries were on the brink of flooding as the shipworms destroyed the wooden dikes, expensive harbour infrastructure was damaged beyond repair and numerous ships had to receive new hulls in order to keep afloat. The implemented solutions and reforms to minimise the shipworm’s effects were manifold and often had far reaching consequences. As such the shipworm’s societal impact was wide-ranged, as it spawned – to name a few examples – religious fanaticism resulting in mass executions of homosexuals in the Dutch Republic, political reforms in the Southern Netherlands, scientific interest in marine biology, a new international balance of power and innovative techniques in ship hull optimisation. This study is based on archival research and on an interdisciplinary approach in collaboration with marine biologists and hydrodynamic engineers. This approach determines the degree of innovation in shipping and its resulting economic efficiency. Boards representing copper sheathed, tar coated and uncoated ship hulls will be contaminated with shipworms and subsequently tested in a towing tank to measure the ships’ water resistance. The shipworm epidemic was an environmental crisis that had a large impact on the North Sea area. Through analysing several case-studies this research aims to show how and why these societies reacted as they did, why some ended up in deadlock and why others were able to turn the tide and profit from this crisis through innovation.

Keywords: maritime history,environmental history,north sea,harbours,baltic trade
REnewable GAs TRAde Centre in Europe (REGATRACE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Ukraine,Germany,Spain,Estonia,Ireland,Italy,Germany,Germany,Austria,Italy,Belgium,Belgium,Greece,Croatia,Poland,Romania,Slovenia,Switzerland,Lithuania,Sweden,Finland,Sweden,Sweden,Latvia,France,Czechia,United Kingdom,Denmark
Call: Market Uptake support (H2020-LC-SC3-2019-RES-IA-CSA, 2019)
Start date: 2019-06-01
End date: 2022-11-30
Duration (months): 42.0
Total project cost (EUR): 3000487.51
EU funding (EUR): 3000485.0
Participants: 35
Project status: SIGNED

REGATRACE (REnewable GAs TRAde Centre in Europe) aims creating an efficient trade system based on issuing and trading biomethane/renewable gases Guarantees of Origin (GoO). This will strongly contribute to the uptake of the European common biomethane market. This objective will be achieved through the founding pillars: - European biomethane/renewable gases GoO system - Set-up of national GoO issuing bodies - Integration of GoO from different renewable gas technologies with electric and hydrogen GoO systems - Integrated assessment and sustainable feedstock mobilisation strategies and technology synergies - Support for biomethane market uptake - Transferability of results beyond the project’s countries. REGATRACE relates, within the H2020 Work Program 2018-2020 on Secure, clean and efficient energy, to the Call BUILDING A LOW-CARBON, CLIMATE RESILIENT FUTURE: SECURE, CLEAN and EFFICIENT ENERGY, with topic LC-SC3-RES-28-2018-2019-2020: Market Uptake support and to the specific issue: Development of cost-effective logistics, feedstock mobilisation strategies and trade-centres for intermediate bioenergy carriers. The intermediate bioenergy carrier is biomethane, a Europe-wide trade centre for biomethane and other renewable gases is necessary for enabling investments to supply the whole European market and for promoting cross-border biomethane trade. REGATRACE supports the mobilisation of biogas feedstocks, which otherwise would not be utilised. Efficient bioenergy logistics refers to biomass conversion and use of the gas grid as the logistic tool. A stable, reliable and common market for biomethane and other renewable gases in Europe plays an important role to achieve EU political targets and to decouple the energy systems from fossil fuels: biomethane/renewable gases can be produced from waste or residual streams of organic material and they can be transmitted and stored in existing infrastructures, so allowing to combine the European natural gas and electricity grids.

Keywords: biomethane,renewable gas,guarantees of origin goo,production,market,registries,sustainability,power to gas