Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Handheld Molecular Contaminant Screener (HMCS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

There is an ever-increasing need for real time detection for risk related substances (e.g. pesticides, bacteria and antibiotics) in agro and food products. Food quality, food frauds and food scandals are becoming a major issue these days. Prime examples of recent food disasters are the Fipronil Dutch egg scandal and Salmonella French baby milk scandal. These scandals have not only resulted in health effects but also resulted in massive economic losses (> € 600m), losses in jobs and damage of the reputation of the European agro and food industry which takes pride in being the best in the world. Current high-end screening methods are laboratory based which are time consuming (5-12 days) and expensive (€200 per hour of testing cost at central labs). By the time results are out, food is already in the processing stage or in the supermarkets. We propose real-time detection of risk related substance using handheld molecular contaminant screener (HMCS) based on a novel portable mass spectrometry technology. With HMCS rather than bringing the sample to the lab you bring the lab to the sample. HMCS enables food companies to test food or food products for contaminants before collecting food from the farms and at various stages of the food value chain. We have validated by speaking with customers such as Freisland Campina (the world’s largest dairy co-operative) and Vion food group to name a few who indicated to pilot HMCS based on the success of feasibility study. The feasibility study in phase 1 will technically validate the value of HMCS validate in terms of sensitivity (parts-per-billion), portability (< 9kg) and speed of detection (< 30 seconds). The economic feasibility study should provide lacking information about the decision making unit (farmer-food companies relationship) in order to validate the business plan.

Keywords: agro and food diagnostics,handheld mass spectrometry ms,bringing the lab to the sample
REsilient WAter Innovation for Smart Economy (REWAISE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Protection of the environment, sustainable management of natural resources, water , biodiversity and ecosystems
Action type: Innovation actions
Countries involved: Spain,Italy,Spain,Spain,Spain,Spain,Spain,Ireland,Belgium,Croatia,Poland,Sweden,Poland,France,Czechia,United Kingdom,Denmark,United Kingdom,United Kingdom
Call: Building a water-smart economy and society (H2020-SC5-2019-2, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 18856096.93
EU funding (EUR): 14984656.81
Participants: 32
Project status: SIGNED

REWAISE will create a new “smart water ecosystem”, mobilising all relevant stakeholders to make society embrace the true value of water, reducing freshwater and energy use, resulting in a carbon free, sustainable hydrological cycle, to transition into a resilient circular economy. A network of nine living labs, involving 5 major water utilities, demonstrates real-life, large-scale operational environments for technological innovations and new governance methods to secure a resource-efficient water supply for the EU. New business niches will be created, incentivizing water-related investments, and accelerating SME growth, by linking users with specific water needs, incorporating life cycle and cost assessments, and collective action in new governance frameworks for smart value creation and high social returns. By incorporating paradigm shifts from a linear Roman heritage to a new circular, water-smart economy, REWAISE reveals the full Value of Water for Europe, considering 3 key components of the economic and societal value generated by integral water cycles: • Value in Water: is accomplished by extracting and putting to beneficial use dissolved substances such as nutrients, minerals, chemicals and metals, as well as organic matter and energy, embedded in raw and used water streams. • Value from Water: encompasses the economic activities inherent to the water cycle, related products and services that generate benefits and jobs, directly or in other sectors that depend on water, such as energy and transportation, • Value through Water: the societal, health and well-being functions of water, which will be enhanced by inter-linking users, regulators, water operators and other stakeholders in electricity and chemicals markets through a digital platform that optimizes decision making and business opportunities through socio-economics-based coordination between them, while minimizing emissions , risks and vulnerability.

Keywords: smart water economy,governance,climate change,resilience,energy recovery,sustainability
Low-cost and Large-Area Perovskite-Silicon Solar Tandem Cells (PerSiSTanCe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

As the world population grows, the total energy demanded increases, despite the limited reserves of fossil energy. Energy sources based on new technologies, such as the photovoltaic cells, emerged as a sustainable and environmentally clean option. However, given that silicon, the base material for most of these cells, fails to absorb the energy of the entire solar spectrum, one interesting option to increase device efficiencies is to produce stacks of complementing cells, thus taking advantage of the full solar spectrum. Tandems of Si and novel perovskite cells are a feasible alternative and can be synthesized from cheap materials. On the other hand, the main requirements of industry are low cost, high throughput and process reliability. Thus, processing techniques and materials should be selected bearing in mind a compromise between cost reduction, acceptable efficiencies and process yield. The aim of this project is to obtain the best suited Transparent Conductive Oxides (TCO), as well as the most appropriate synthesis and deposition methods for their implementation in tandem Si/perovskite cells, substituting other layers whose use would involve scarce/strategic materials or difficult and/or expensive processes. The result should be a more robust process, which helps to close the gap between laboratory devices and the future mass production cells.

Keywords: solar cells,perovskite,perovskite silicon tandem solar cells
Probing mechanisms of pathogen effector recognition by plant Resistance proteins to elevate defence gene activation (PERFECTION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Plant cells tightly regulate gene transcription in response to a changing environment. Stresses, such as pathogen encounters, lead to dramatic transcriptional reprogramming to favor defence activation over basal cellular functions. For effective defence, cells must rapidly alter defence gene mRNA abundance. How extracellular and intracellular recognition of plant pathogens trigger appropriate changes in host mRNA abundance is poorly understood. Upon recognition of pathogen effectors, resistance proteins activate plant defence by unknown mechanisms. My host lab recently reported that the Arabidopsis Resistance gene pair RPS4/RRS1-R elevates expression of certain defence genes, such as those required for salicylic acid biosynthesis, within four hours of detecting PopP2 effector in Arabidopsis. The main goal of this proposal is to understand how effector recognition by RPS4/RRS1-R leads to rapid defence gene induction. We will test the hypothesis that RPS4/RRS1-R proteins directly interact with gene loci that are activated during this process. I will use transgenic Arabidopsis that carry a single genome locus with independently epitope-tagged RPS4, RRS1 and other defence-implicated proteins to investigate: (1) changes in composition of the RPS4/RRS1-R protein complex upon effector recognition using mass spectrometry; (2) effector-induced changes in association of the RPS4/RRS1-R proteins with induced genes using chromatin immunoprecipitation; (3) changes in chromatin status at induced gene regions correlated with gene induction and activation of defence by RPS4/RRS1-R. From this project, I will rigorously test an important model, namely that plant immune receptor complexes directly mediate transcriptional reprogramming of defence genes through chromatin changes upon recognition of effectors. I bring highly complementary expertise in genetics and transcriptional regulation of basal defence from China to Canada and now to TSL that is essential for this project’s success.

Keywords: nb lrr resistance proteins,effector triggered immunity,co transcriptional regulation,defence genes,sustainable crops
Drug eDesign: Building the next generation of software solutions for drug design (eDrug)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-01-01
End date: 2016-06-30
Duration (months): 18.0
Total project cost (EUR): 148875.0
EU funding (EUR): 148875.0
Participants: 1
Project status: CLOSED

Computer simulations are taking over in design processes. Nevertheless, complex projects will largely benefit from human intuition and team-work. We aim to combine computer and human power into the next generation of fully interactive computational tools for drug design. The goal of eDRUG is prove the potential of this novel computational solution in the current pipeline of drug development and the prospective interest that it will raise in the pharmaceutical industry. We aim at merging human knowledge with state of the art affordable computational resources to create an interactive and (capable of) intuition-guided software solution. The idea seats on three technological pillars: 1) the PELE software allowing fast biophysical characterization of drug-target interactions, 2) advances in computational hardware providing more computational performance in reduced space, requiring lower power consumption and acquisition cost, and 3) better graphical devices allowing a richer and faster human(team) data analysis and software interaction. The goal matches with increasing and future needs from pharmaceutical companies to improve rational drug design (in response to cell/virus mutations, personalized medicine, etc.). One worldwide leading pharmaceutical company, and a local biotech SME, will be counseling the developing team and testing the prototypes, to meet a product that fulfills industry expectations.

Keywords: pele,drug design,hardware,software solution,supercomputing
microRNA biomarkers in an innovative biophotonic sensor kit for high-specific diagnosis (miRNA-DisEASY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Spain,Italy,Germany,Brazil
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2015-12-01
End date: 2019-11-30
Duration (months): 48.0
Total project cost (EUR): 490500.0
EU funding (EUR): 445500.0
Participants: 7
Project status: CLOSED

Since 2001’s discovery of microRNAs (miRNAs) in humans, progress in genomics and transcriptomics has increased our comprehension of gene expression regulation. miRNAs are small, noncoding RNA molecules showing huge promise as clinical biomarkers and diagnostic tools for illness and disease, as significant changes in their expression occur in response to pathological states. However, miRNA detection is still challenging nowadays, since costly, complex sample preparations and RNA amplifications are not yet reliable enough for clinical decision making. In this context, three innovative EU companies, Optoi Microelectronics - with microelectronic knowhow and manufacturing skills - DestiNA Genomics - with ‘error free’ chemical technology for microRNAs recognition – and GeneXplain – with bioinformatic capabilities - joined forces with four key academic research groups from the Universities of Trento (Italy), Granada (Spain), Hannover Medical School (Germany) and Santa Catarina (Brazil). All the parties combined their knowledge with respect to miRNA biomarkers with a particular focus on lung cancer, to develop a novel and reliable miRNA detection system for this disease. To this end, research collaborations will address the analysis of miRNAs specifically over-expressed in lung cancer, continuing experimental work already started in the past years, but with greater integration and focus. Existing close partnerships with healthcare institutions will be strengthened, ensuring multi-site and multi-ethnic sampling. In parallel, optimization and validation of a miRNA detection kit based on Optoi semiconductor optical detector will continue. The DestiNA patented technology for specific nucleic acid recognition will be refined to reach the integration and result reliability required for use in clinical point of care testing. The strong network created between the companies and the academic institutions will thus provide a unique scientific and technological environment to turn the research outputs into an innovative product for healthcare advance and progress.

Keywords: microrna,biomarker,lung cancer,biophotonic silicon sensor,dynamic chemistry,optical detection,test kit,early diagnosis,clinical validation,multi ethnic samples
Neurological application validation for photon counting spectral CT (NEUROSPECT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Sweden
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

This project is a spin-off from a 6 MEUR and six year research effort at the Royal Institute of Technology (KTH) where a photon counting detector for spectral computed tomography has been developed. A functional bench-top prototype already exists and has been used for phantom image acquisition as well as system evaluation and optimization. Remaining items are determination of the final modular design, especially to find the correct point on the performance-cost-trade off curve and related to this are which market segment will be approached. The phase 1 feasibility study and business plan development will address these issues as well as several other strategic questions important for maximizing the commercial potential of the innovation. Our working hypothesis is that neuroradiology is the best segment to approach since spectral imaging capabilities are likely to help determine the vulnerability of carotid plaques to rupture (and cause stroke) and also for brain profusion measurements where any residual blood flow is essential in determining the correct treatment scheme after a stroke. Head and neck applications combined with brain imaging constitute 25% of all CT procedures and is considered a high-end segment. This make makes entering the market at a price premium easier. The physical size of the detector, and thus manufacturing cost, is in the mid-range in this segment which is an additional benefit; the projected cost of this new technology is reasonable. Our foreseen business model is to supply modularized detector modules to a preferred system vendor for integration in their gantry. A vendor supplied CT gantry is already installed and fully functional and first integration tests have already begun. As part of the feasibility study we will jointly determine on a set of system integration parameters and functional specifications the fulfilment of which will result in the first orders of full scale detector modules.

Keywords: spectral computed tomography,energy resolved ct,stroke,in situ carotid plaque risk asessement,x ray detector development,medical imaging
Digital avalanche safety - Rethink the off-piste and backcountry skiing experience (DINGO SME-1)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2019-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

DIGITAL AVALANCHE SAFETY --- rethink the off-piste and backcountry skiing experience. The overall objective of the innovation project is to commercialise novel avalanche safety products. The target outcome of the project is to commence production and sales of a first ‘smart ski’ series, co-branded with a high-end ski manufacturer. THINK OUTSIDE is a pioneer in digital avalanche safety. We will bring precautionary snow analysis into the skiing mainstream, with DINGO for avalanche risk assessment and for advanced motion tracking. DINGO informs skiers when the snow layers have alarming properties, and maps the results. This can enable timely navigation and alerts to others. On average, 150 people die in avalanche accidents each season, typically off-piste or in the backcountry, and typically the avalanche was triggered by the person who was hurt or killed. We aim to bring these numbers down, and the market is ripe for smarter, safer products. Surveys confirm a solid willingness to pay for DINGO, among the average person looking to purchase new skis. We have partnered with high-end ski manufacturer ÅSNES for co-production, co-branding, and a commercial pilot launch of our products before the 2019/2020 winter season. This 6-month feasibility study leads to a commercial pilot, where ski manufacturer Åsnes will market a ski series with a first version of DINGO embedded and co-branded. Our products are truly state-of-the-art, and we are more than enthused about the slopes ahead. Our company is run by senior managers and entrepreneurs who have teamed up to launch DINGO and to build up THINK OUTSIDE as a global pioneer in avalanche safety.

Keywords: radar,sensor,snow,avalanche,safety,snowboard,machine learning,big data,layer analysis,software,hardware
SWIPT- MED: Simultaneous Wireless Information and Power Transfer for Medical Implants (SWIPT-MED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 284345.28
EU funding (EUR): 284345.28
Participants: 2
Project status: TERMINATED

The growth and extensible research in active implantable medical devices (AIMDs) have provided the opportunity for continuous and remote monitoring of patients with chronic illness. But the major technological challenge is that most of the implants operate on batteries with limited durability. It is difficult to replace these implants as human tissues grow around them and requires surgeries for their removal, which are costly and stressful for the patients. Moreover, battery replacement surgeries require hospital stays which is an additional risk in this era of pandemics like COVID-19. So, the sustainability and eventual fate of implantable medical devices depends on its capability for long-term use. Most of the AIMDs are equipped with wireless communication systems for data transfer, device monitoring and reprogramming. In this regard, I propose that energy harvesting from radio frequency (RF) signals for a wireless communication system provides a new paradigm called Simultaneous Wireless Information and Power Transmission (SWIPT) that can allow the wireless implant nodes to recharge their batteries from the RF data signals. In the literature, SWIPT has been studied for in-door and outdoor environment and has investigated transmission of high energy levels with large antenna dimensions for harvesting energy. There have been no studies in the literature for investigating SWIPT within the human body. My research project will explore and untap the potential of SWIPT for the human body environment. The major outcomes of the project include: 1) optimum energy-capacity function and the end-to-end analytical model of SWIPT for deep implants; 2) hardware design of SWIPT for implant communication systems; and 3) feasibility of the novel SWIPT architecture for medical implant technology by in-vitro liquid phantom models and in-vivo living animal experimental studies. The new fundamental knowledge developed from the project could be applied to multiple other domains.

Keywords: wireless power transfer,biomedical implants,in body communication,body area networks,cardiac pacemaker