Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Energy Efficiency with Performance Guarantees in Private and Public Sector (guarantEE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Spain,Ireland,Italy,Austria,Germany,Lithuania,Romania,Slovenia,Slovakia,Norway,Belgium,France,Czechia,Netherlands
Call: Development and market roll-out of innovative energy services and financial schemes for sustainable energy (H2020-EE-2015-3-MarketUptake, 2015)
Start date: 2016-04-01
End date: 2019-03-31
Duration (months): 36.0
Total project cost (EUR): 1586558.2
EU funding (EUR): 1586558.2
Participants: 14
Project status: CLOSED

Energy Performance Contracting (EPC) is a proven model for modernizing mostly public buildings by ESCOs with guaranteed energy and cost savings. Nevertheless, a broad roll-out of EPC is being prevented mainly because of two unresolved issues: the split incentives dilemma and the lack of adequately flexible contract models. The guarantEE project will address prevailing barriers to EPC in a team of 14 experienced partners, covering large parts of Europe in a mix of advanced and emerging ESCO markets. Based on a concise market analysis, guarantEE will develop innovative business and financing models addressing and overcoming the split incentives dilemma in performance based ESCO projects. This will be done by adequately sharing costs and benefits between user, building owner and ESCO (triple-win approach), thus opening up new project opportunities. Furthermore, EPC contract variants will be elaborated and tested, addressing the need for enhanced flexibility (e.g. exit clauses, simplified M&V, future energy market needs, storage). The target groups are public and – especially in advanced EPC markets – private sector clients. The developed models will be applied in 33 pilot projects involving private and public building owners. The project will achieve 78 GWh PE and 18000 tCO2 savings per year and will trigger investments of >11 M€. Particularly in emerging EPC markets, guarantEE will support market development by providing standards, an online EPC pre-check, good practice examples, EPC information and project facilitation for mainly municipal clients. Broad dissemination activities, including the European Energy Service Award, will maximise the project visibility. The project will address or consult at least 1000 building owners and EPC facilitators and will inform at least 2000 energy sector stakeholders on EPC. The guarantEE project will unlock additional EPC project opportunities, contribute to standardisation, and provide political advice and steps towards a common energy service market in Europe.

Keywords: energy performance contracting,energy savings,energy effiency,esco
Identifying neuronal or muscle cell-specific suppressors that rescue motility defects in the ALS model of the nematode worm Caenorhabditis elegans (RescueMoDe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-08-02
End date: 2023-08-01
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: SIGNED

Amyotrophic lateral sclerosis (ALS) is a fatal disease that progressively causes loss of neuronal and muscle function, for which there is no known cure. Although the genetic causes of ALS vary, the cytoplasmic accumulation of the TDP-43 protein in neurons is highly consistent among patients. Thus, TDP-43 is believed to be a point of convergence in the pathway responsible for ALS progression. However, while many genetic and cellular mechanisms have been linked to ALS, there is still a lack of understanding of the neuro-muscular interactions in ALS. In this project, we will identify neuronal or muscle cell-specific suppressors of motor impairment using an ALS model in the nematode worm Caenorhabditis elegans. In this model, transgenic C. elegans overexpress TDP-43 in the neurons, resulting in severe motility defects. We will use optogenetic tools to excite neurons and muscle cells separately in the C. elegans ALS model, contributing to our understanding of how TDP-43 accumulation affects tissue function. In addition, live in vivo microscopy of C. elegans will help us to elucidate the impact of TDP-43 on neuro-muscular interactions over time. Furthermore, novel automated tracking of the nematode worms enables high-throughput analysis of C. elegans mobility. Thus, we can efficiently analyse mobility when TDP-43 is overexpressed, and use this tracking for high-throughput screening of mutants that rescue the ALS phenotype. Once we have identified the mutants that Rescue Motility Defects (RescueMoDe), we will characterize their impact on neuronal and muscular function. Therefore, it will be possible to analyse the tissue-specific role of these candidates, and how they fit into the progression of TDP-43 toxicity in this system. Overall, we aim to further the understanding of ALS progression, which will allow a highly informed continuation of studies in mammalian cell culture or in murine model systems, which may lead to therapeutic research opportunities.

Keywords: amyotrophic lateral sclerosis,neurodegeneration,neurodegenerative disease,optogenetics,c elegans,live imaging,forward genetic screening,protein aggregation
Plug-n-Play Tool-kit of Organ-on-Chips (PTOoC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-11
End date: 2021-10-10
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

Off late, there has been a tremendous surge in the cost of bringing new drugs to the market. The rising costs and ethical concerns related to screening with animal models have led to the development of alternate approaches for drug discovery. Owing to the advantages of high physiological relevance and predictive value, Micro-physiological systems (MPSs) (also referred to as Organ-on-chips (OoC)) are gradually taking over as powerful and cost-effective alternative to animal model-based drug screening. However, OoCs have yet to cross certain key barriers, before they are adopted as an industry standard for drug screening. The current state-of-the-art in OoCs suffer from a low standardization level, low throughput workflow, in comparison to conventional cell culture-based methods. The main objective of the project is to design and develop a library of inter-lockable hard-soft hybrid components, which can be used to construct any given organ-on-chip at the required physiological/functional scale. Each part of the library would serve to enable a certain physicochemical stimulus/structure warranting its use in the design of a specific type of organ-on-chip. The overall library would contain all the required parts to enable implementation of different microenvironments from different organs of the human body. The development of such parts would enable a standardized approach to OoC development and testing across the industry. The project will have a preliminary focus on demonstrating the proof-of-concept for assembling a lung-on-chip OoC from the developed modular components. Followed by integration of different organ-on-chips with functional scaling and parallelization for high-throughput. The project has a strong multi-disciplinary nature with expertise involved from fields of engineering/mechanical design, microfluidics, biological cell culture/microbiology.

Keywords: microfluidics,organ on a chip,biomaterials,in vitro models,pharmaceutical testing
cyberSecurity Optimization and Training for Enhanced Resilience in finance (SOTER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Improve cyber security
Action type: Innovation actions
Countries involved: Austria,Spain,Spain,Spain,Spain,Austria,Ireland,United States,United Kingdom,United Kingdom
Call: Digital security, privacy, data protection and accountability in critical sectors (H2020-SU-DS-2018, 2018)
Start date: 2019-07-01
End date: 2022-02-28
Duration (months): 32.0
Total project cost (EUR): 4105173.75
EU funding (EUR): 3026246.13
Participants: 14
Project status: CLOSED

The Digitalization Era implies many advantages for businesses and citizens. However, new threats arise, especially in what concerns data privacy and the use of digital identities. These threats must be tackled under a holistic approach and pointing at their different origins, including the human factor. The European Union is reinforcing the legal framework to contribute to this need, including important requirements to be fulfilled, especially in the context of critical sectors identified under the NIS Directive. Finance is one of them, actually the most restrictive, because of the number of regulations to comply with. This makes finance the perfect scenario for testing tools, before transferring the results to other sectors. That is why SOTER is mainly focused on it, aiming at providing a comprehensive set of tools that will act as a transformative process of the finance sector, helping their players to increase their cybersecurity level, enabling the fight against present and future cyberattacks and vulnerabilities. The results will then increase their cyber-resilience. SOTER main results will be: SOTER Digital Onboarding Platform (the technology tool to provide a robust and sovereign digital identity, facilitating the interconnections between different services providers and the users), improved by the use of blockSOTER will offer tools that are able to determine the level of cyber security that exists in a certain entity, to improve if that is the case. We intend to get this through a comprehensive risk analysis to create contingency plans and direct action measures that can mitigate threats and security attacks. In the case of the finance sector, we propose to test and analyze a cloud platform of Digital Onboarding with two main features: • use of technologies blockchain • innovative systems of biometric identification of users Derived from this, training actions for end users will be generated so they are able to detect and deal with this type of threats.

Keywords: authentication,on boarding,finance,awareness,training,cybersecurity,human factor
Synthetic toolkit for fragment oriented synthesis (SYNFOS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Fragment-based ligand discovery (FBLD) has become a mainstream strategy to discover new drugs to enable the treatment of conditions with unmet medical needs. Despite the remarkable rise of FBLD, significant chemical challenges remain in the field; firstly, elaborated fragments tend to be synthesised de novo when direct growth would be much more advantageous. Secondly, the currently available toolkit for fragment elaboration tends to exacerbate an uneven exploration of chemical space, yielding flatter and more lipophilic compounds. SYNFOS will allow Alexandre Trindade (the fellow) to join the laboratory of Professors Adam Nelson (host supervisor) and Steve Marsden (host co-supervisor) at the University of Leeds (Host) and develop research expertise in fragment-based ligand discovery; catalysis to enable molecular discovery; protein-protein interaction (PPIs) inhibition; and high-throughput X-ray crystallography (via secondments to Diamond (Partner)). In doing so, the fellow will (a) enhance his prospects of becoming an independent academic group leader in Europe and (b) address the need to train researchers in key multidisciplinary areas such as medicinal chemistry and chemical biology and (c) develop cutting edge synthetic methods that facilitates the fragment-based discovery of new inhibitors for protein-protein interactions. By building in fragment hits from the Host laboratory, the fellow will establish a synthetic toolkit enabling the functionalization of C-H bonds within N-heterocycles with a wide range of medicinally-relevant groups. The fellowship will explore three main modes of reactivity to establish the functionalization of sp3-hydridised carbons with heterocyclic fragments and showcase the value of the synthetic toolbox through the discovery of fragments hits into potent inhibitors of PPIs involving the ATAD2 bromodomain.

Keywords: fragment based ligand discovery,photoredox catalysis,metallocarbenoid chemistry,inhibitors of protein protein interactions
Commercialising Innovative Disruptive Solution for Improving Human Resources Management and Practices (HappyHR)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Finland
Call: New business models for inclusive, innovative and reflective societies (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-03-01
End date: 2018-05-31
Duration (months): 15.0
Total project cost (EUR): 991250.0
EU funding (EUR): 689500.0
Participants: 1
Project status: CLOSED

HappyOrNot are global leaders in a market niche we have helped create – that of instant customer satisfaction reporting for the retail stores where since 2009 we have acquired over 2.500 clients. Our product is a portable smiley terminal that allows for quick feedback on client satisfaction levels with reports and statistics delivered directly to management. Through the interactions with our clients, we have found a great opportunity for our product within the HR industry. The global HR industry (worth $619 billion) has been going through difficult times with the world recession underway for 8 years now. As companies have reduced costs, restructured and pushed people to work harder than ever, 60% of organisations state that dealing with “the overwhelmed employee” is their top priority. It is these, and other, issues in the HR industry that have created a market opportunity for a device that enables new business models through the collection of realtime data about employee satisfaction markers. Our product allows companies across all fields to perform a key strategic function in a way that will provide clear benefits through the reports on the state of the workforce – both for the companies and their employees. And considering it is a hardware terminal that can be placed anywhere in the company, it also functions as a tangible reminder of the managements commitments to improving working conditions while enabling employees to provide feedback in a fully anonymous manner. Anonymity is currently the biggest barrier for all the digital solutions that are available on the market. This HappyHR project will serve to bring our product to a new market while enabling us to understand how our product needs to be adapted. It will move our product to full commercial readiness for a Europe-wide launch and will enable our company continuous success with turnover expectations of over €13.3 million and accumulated net profit of €19.6 million 5 years post project completion.

Keywords: hr industry,hr management,employee satisfaction,employee engagement,hardware,terminal,satisfaction reporting,hr trends,hr strategic change,employee reporting,workforce,state
Evolution and Variability of Climate Sensitivity and Polar Amplification during CeNozoic Warm Climates SPANC (SPANC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-09-01
End date: 2024-02-29
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Forecasting the magnitude of future global warming is among the great scientific challenges. Model estimates of long-term warming resulting from a doubling of the CO2 concentration relative to the pre-industrial era range between 1.5 and 4.5 °C. The large uncertainty in this Equilibrium Climate Sensitivity (ECS) may represent the difference between the melting or conservation of large continental ice sheets, and between habitable and inhabitable regions. SPANC will quantify ECS through accurate reconstructions of past climate change. Existing ECS studies largely focus on periods that were colder than present. Importantly, however, my development of a reliable method to reconstruct past CO2 concentrations now allows for estimates of past warm climates that can serve as analogs for the future. First, I will calibrate the new CO2 proxy for high CO2 levels. Uniquely, my new approach allows CO2 and temperature reconstructions to be based on the same samples, implying optimal time control. This provides the outstanding opportunity to generate high-quality coupled CO2 and temperature reconstructions for the ice-free early Eocene and the warm but glaciated middle Miocene at unprecedented resolution. This allows ECS to be calculated based on long and short-term variability in CO2 and temperature. The combination of ice-free and glaciated periods will also determine the extent to which the presence of ice governs climate response to CO2. Study locations will be carefully selected across pole-equator transects. This allows for quantification of the amplification of temperature changes towards polar regions, crucial for ice sheet extent and volume and hence global sea levels. SPANC will provide a breakthrough regarding the ECS of warm climates. It will provide crucial new constraints on the ability of climate models to correctly simulate warm climates and climate variability forced by changes in CO2 concentrations, which is vital for reliable future climate projections.
Reinventing the liquid waste disposal process (WAS2VAL)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: Switzerland
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-11-01
End date: 2024-03-31
Duration (months): 41.0
Total project cost (EUR): 4887367.0
EU funding (EUR): 2425795.75
Participants: 1
Project status: SIGNED

The treatment of sewage sludge, the by-product generated during wastewater treatment, represents one of the biggest problems for small and medium sized wastewater treatment plants (WWTPs), due to the adoption of stringent rules towards resource valorization and the minimization of adverse effects on the environment. Besides it entails high costs (CAPEX and OPEX) for the plants. This situation is pushing WWTPs to seek urgently for cost-efficient, ecological and clean disposal solutions for their sewage sludge. TreaTech, a Swiss based private company, has developed a unique sewage sludge treatment technology – A catalytic hydrothermal gasification (HTG) system - that can convert different types of liquid wastes that are typically incinerated or landfilled into useful products including biogas, clean water, and mineral salts, which can be further upgraded into various phosphorus-based products (e.g. fertilizers). TREATECH is disrupting the Wastewater Treatment market by providing a solution for sewage sludge treatment with 40% lower CAPEX, 50% lower OPEX, and 94% lower CO2 emissions than equivalent technologies while requiring 71% less space. Whereas anaerobic digestion converts sewage into renewable gas over a matter of weeks, our technology only requires a few minutes to generate up to 80% more renewable gas. The commercialization of our HTG units will have a great impact in the growth of our company, reaching €535 million of revenues, €126 million of profits and leveraging the creation of 36 new jobs by 2028. We expect to process 161,310 tons of sewage sludge disposal by 2028, reaching around 22% share of the Swiss market and 1% of the European market share. The implementation of our technology into the market, will contribute to reduce by 2030, 163,000 tons of CO2eq emissions while recycling added value products: 126,000 tons of clean water, 10,000 tons of Phosphorus and 475Gwh of biogas.

Keywords: sewage sludge,wastewater treatment,valorization,biogas,renewable energy,salt minerals,phosphorus,clean water,renuable energy
Programmable Enzymatic Synthesis of Bioactive Compounds (ProgrES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-07-01
End date: 2024-06-30
Duration (months): 72.0
Total project cost (EUR): 2399831.0
EU funding (EUR): 2399830.0
Participants: 1
Project status: SIGNED

Enzymes are now established as highly selective biocatalysts in organic synthesis with the range of catalysts and reactions rapidly increasing through access to large protein databases and high-throughput molecular biology tools for biocatalyst engineering. The diversity of biocatalytic reactions is now at a stage where they can be linked in (chemo)-enzymatic reaction cascades, where two or more chemical and/or enzymatic reactions can be catalysed simultaneously generating de novo biosynthetic pathways for chemical synthesis not found in Nature. These reaction cascades have demonstrated important prior art, however they have been mostly limited to few steps and lack the complexity provided by the natural pharmacopeia. ProgrES aims to achieve a step-change by introducing unprecedented structural complexity into de novo pathways and by moving away from manual to automated, high-throughput cascade design and implementation. The proposal is to use a transdisciplinary approach that addresses three important bottlenecks: i. Identification of enzymatic reactions that allow early functionalisation and late stage diversification of the cascade toolkit to increase structural complexity, building on C-H activation mediated by monooxygenases, which are well established in our research group. ii. As diversity of targets increases, high resolution structural analysis of pathway intermediates and products becomes a bottleneck, which is addressed by high-throughput label free mass spectrometry based analytical tools that will match the demands on timescale and numbers. iii. In parallel, we will establish bioinformatics tools adapted from both chemical synthesis and biosynthesis, to allow programmable enzymatic synthesis for cascade design. As proof-of-concept and test bed for the ProgrES platform we aim to generate a library of diverse synthetic imino sugars. This proposal will lead to a major breakthrough in creating a diverse range of scaffolds of therapeutic interest.

Keywords: biocatalysts,organic synthesis,reaction cascades,de novo biosynthetic pathways,analytical tools,programmable enzymatic synthesis,imino sugars