Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Continuity and Rupture in Central European Art and Architecture, 1918-1939 (CRAACE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Czechia,United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-09-01
End date: 2024-02-29
Duration (months): 66.0
Total project cost (EUR): 2468359.0
EU funding (EUR): 2253013.29
Participants: 2
Project status: SIGNED

When new political elites and social structures emerge out of a historical rupture, how are art and architecture affected? In 1918 the political map of central Europe was redrawn as a result of the collapse of Austria-Hungary, marking a new era for the region. Through comparative analysis of the visual arts in 3 states built on the ruins of the Habsburg Empire (Austria, Hungary and [former] Czechoslovakia), this project examines how such political discontinuity affected art and architecture between 1918 and 1939. The project is organised into 4 themes, each resulting in a monograph: 1. Vernacular modernisms, nostalgia and the avant-garde 2. Presenting the state: world fairs and exhibitionary cultures 3. Piety, reaction and renewal 4. Contested histories: monuments, memory and representations of the historical past It is the first systematic and comprehensive trans-national study of this type, based on the claim that the successor states to Austria-Hungary belonged to a common cultural space informed by the shared memory of the long years of Habsburg society and culture. The project focuses on the contradictory ways that visual arts of artists and architects in central Europe adapted to and tried to shape new socio-political circumstances in the light of the past. The project thus examines the long shadow of the Habsburg Empire over the art and culture of the twentieth century. The project also considers the impact of the political and ideological imperatives of the three successor states on the visual arts; how did governments treat the past? Did they encourage a sense of historical caesura or look to the past for legitimation? How did artists and architects respond to such new impulses? In answering these questions the project analyses the conflicts between avant-gardes and more conservative artistic movements; the role of the visual arts in interwar memory politics; the place of art in the nexus of religion, national and state identity.

Keywords: austria,hungary,czechoslovakia,habsburg empire,modernism,avant garde,post imperial legacies,cultural memory
Generation of ultra-deep libraries of transcriptional activators for gene therapy (Diverge)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-04-01
End date: 2020-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

We have generated a novel genetic circuit that, by combining an unusual site-specific recombinase and molecular splicing, allows to functionally diversify modular proteins in-vivo in a highly-directed manner. Applying this method to modular transcriptional activators allowed us to generate billions and even trillions of transcription factors variants in-vivo starting from a single base construct. The aim of the DIVERGE PoC project is to to explore the commercial potential of this approach for the isolation of transcriptional activators for human gene activation therapy and to establish a strategy for commercialisation of current and conceivable future implementations of this technology.

Keywords: synthetic biology,transcription factors,gene activation therapy,genetic disease
Antibody therapy against coronavirus (COVID-19) (ATAC)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Switzerland,Belgium,Sweden
Call: Advancing knowledge for the clinical and public health response to the 2019-nCoV epidemic (H2020-SC1-PHE-CORONAVIRUS-2020, 2020)
Start date: 2020-04-01
End date: 2023-07-31
Duration (months): 40.0
Total project cost (EUR): 5620040.0
EU funding (EUR): 5595040.0
Participants: 5
Project status: SIGNED

ATAC aims at developing passive immunotherapy against COVID-19. Human antibodies will be obtained from blood of CoV-recovered donors from China and Italy with three independent approaches: polyclonal gamma-globulins, B cell monoclonals and phage libraries. Antibodies will be characterized by rapid experimental and computational work, optimized, produced and tested in consultation with EMA to ensure prompt embedding of regulatory aspects. The partners have outstanding experience in all aspects of the project, collaborated previously and worked on antibody therapy for diseases including SARS and MERS-CoV. Reagents and experienced personnel are already available ensuring quick and efficient progress, with initial deliverables within 3 months. Besides providing a lead human antibody candidate for therapy, ATAC will rapidly disseminate results to help respond to the current COVID-19 epidemic. Results of the 40 months project will also further our understanding of CoV neutralization, contributing to future vaccination and therapeutic strategies. The team includes the Karolinska Institutet (SE, Pan-Hammarström and Hammarström, coordinators), the Institute for Research in Biomedicine (CH, Varani and Robbiani); the Joint Research Centre- European Commission (BE, Calzolai); Technische Universität Braunschweig (DE, Hust) and Policlinico San Matteo (IT, Baldanti). The partners’ outstanding expertise is attested by high impact publications on antibody treatment for emerging infectious diseases.

Keywords: coronavirus,passive immunisation,polyclonal antibodies,monoclonal antibodies,recombinant antibodies
The Strominger system of differential equations (STROMINGER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

This project is devoted to the study of a system of partial differential equations of great relevance in modern geometry and theoretical physics. The Strominger system arises in the theory of heterotic supergravity and has been proposed by Shing-Tung Yau as one of the fundamental perspectives of complex geometry, in relation to the moduli problem for Calabi-Yau manifolds. The goal is to complete four research tasks, designed, on the one hand, to make progress on Yau's conjecture for the Strominger system and, on the other hand, to understand rigorously, in one simple example, a conjectural, fundamental, symmetry of the underlying physical theory, known as (0,2)-mirror symmetry. This will be achieved using the cutting-edge theory of generalized geometry introduced by N. Hitchin. The expertise of the supervisor L. Álvarez Cónsul and the host group at the Instituto de Ciencias Matemáticas (ICMAT, CSIC), leaders in the research line moduli spaces and geometric structures, combined with the expertise of the experienced researcher M. Garcia Fernandez, constitutes an essential backup and impulse for the achievement of the objectives of this project. The host group and ICMAT, in close relation with the Institute of Theoretical Physics (IFT) in Madrid and the Mathematical Institute in Oxford (Hitchin Laboratory), ensures an outstanding training of the applicant through the overall implementation of this research action. In addition, the ICMAT provides an exceptional atmosphere and management structure, and all the necessary infrastructures for the success of the Marie Curie action.

Keywords: strominger system,mirror symmetry,heterotic string theory,calabi yau
GMSPAZIO Satellite Tracking Toolkit (GSTT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Italy
Call: SME Instrument (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

GMSPAZIO Satellite Tracking Toolkit (GSTT) helps satellite owners to successfully manage Space Situational Awareness. GSTT helps the users to steer a satellite platform to a safer position avoiding collisions and extending expected lifetime cycle with more accurate and precise manoeuvres while reducing costs and delivery time, by using the system Planning, Scheduling, Acquisition and Data Processing features. GSTT measurements applied to manage GEO space platforms give satellite owners the capability to assess real platform position with a maximum margin of error of 20 meters. GSTT is a ground-breaking innovation capable to make a major contribution to the maintenance and safety of European strategic assets such as GALILEO constellation. The TRL of GTSS is Level 8 (system complete and qualified): an specific version of GSTT named GMSPAZIO Satellite Awareness Toolkit is fully operational at an Italian Ministry of Defence site since December 2012. The project specific objectives are to study the product process of industrialization -from an operational prototype to an industrialized system- in order to make it available to the market as a customized turnkey solution; to study the Market – identifying the main competitors, potential risks, Marketing strategies and Pricing & Distribution policies - to support GSTT commercialization and to design a Business Plan with 5-year projection (income statements, balance sheet and cash flow statements) based on reliable and cautious assumptions in order to demonstrate the significant return on investment at European level.

Keywords: space situational awareness ssa software tool,satellite tracking manoeuvres assistance,collision avoidance,orbital determination,precise position estimation,life cycle time extension
Development and Implementation of a Sustainable Modelling Platform for NanoInformatics. (NanoInformaTIX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Spain,Ireland,Italy,Italy,Israel,Germany,Germany,Germany,South Africa,Estonia,Italy,Italy,Spain,Taiwan, Province of China,Switzerland,Belgium,Finland,Greece,Poland,Switzerland,Norway,Greece,China,Bulgaria,France,France,France,Netherlands,Denmark,United Kingdom,Portugal,Denmark,United Kingdom
Call: Nanoinformatics: from materials models to predictive toxicology and ecotoxicology (RIA) (H2020-NMBP-TO-IND-2018, 2018)
Start date: 2019-01-01
End date: 2023-02-28
Duration (months): 50.0
Total project cost (EUR): 7751271.25
EU funding (EUR): 6783556.25
Participants: 37
Project status: CLOSED

NanoInformaTIX aims to create a comprehensive, sustainable, multi-scale modelling framework for exposure and (eco)-toxicity of Engineered Nanomaterials (ENM) to facilitate cost-effective risk assessment, less reliant on animal testing, and to support the design of safer materials and products. Our approach integrates several relevant EU/US databases with validated nanoinformatics models covering: Materials, Exposure, Physiologically-Based Pharmacokinetics (PBPK), Quantitative-Structure-Activity Relations (QSAR) and Systems Biology modelling and in vitro/in vivo extrapolation to support the prediction of biological effects and exposure of ENM at various stages of their life cycle and product development. NanoInformaTIX will address grouping and read-across for risk assessment and safer product design. NanoInformaTIX will use existing curated data from several completed EU/US projects and from peer-reviewed literature to develop, extend the models and will also consider emerging data from ongoing projects for model validation following the OECD validation principles. This will take the NanoInformaTIX models from TLR4 to TLR6. The NanoInformaTIX modelling framework will be a web-based platform with a user-friendly interface tailored to the needs of different stakeholders (industry, regulators, academia and the civil society). To obtain optimal confidence in the use of the NanoInformaTIX modelling and database framework, all models will be described clearly using agreed standards terminology and implemented on harmonized standard operating protocols based on Good Modelling/Software Design practices. Their applicability domain will be clearly documented and referenced for full transparency and detailed user guidance for each will be provided. NanoInformaTIX will achieve considerable impact by providing the much -needed validated accessible data management modelling framework to predict human and environmental risks, to support the design of sustainable ENM and products.

Keywords: engineered nanomaterials grouping,classifying,multi scale material modelling,exposure,pbpk,qsar,systems biology models,web based platform,safe by design,reduction of animal experiments
Predicting the effects of gut microbiota and diet on an individual’s drug response and safety (BugTheDrug)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Ireland,Luxembourg
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-04-01
End date: 2023-12-31
Duration (months): 69.0
Total project cost (EUR): 1687458.0
EU funding (EUR): 1687458.0
Participants: 2
Project status: SIGNED

Precision medicine is an emerging paradigm that aims at maximizing the benefits and minimizing the harm of drugs. Realistic mechanistic models are needed to understand and limit heterogeneity in drug responses. Consequently, novel approaches are required that explicitly account for individual variations in response to environmental influences, in addition to genetic variation. The human gut microbiota metabolizes drugs and is modulated by diet, and it exhibits significant variation among individuals. However, the influence of the gut microbiota on drug failure or drug side effects is under-researched. In this study, I will combine whole-body, genome-scale molecular resolution modeling of human metabolism and human gut microbial metabolism, which represents a network of genes, proteins, and biochemical reactions, with physiological, clinically relevant modeling of drug responses. I will perform two pilot studies on human subjects to illustrate that this innovative, versatile computational modeling framework can be used to stratify patients prior to drug prescription and to optimize drug bioavailability through personalized dietary intervention. With these studies, BugTheDrug will advance mechanistic understanding of drug-microbiota-diet interactions and their contribution to individual drug responses. I will perform the first integration of cutting-edge approaches and novel insights from four distinct research areas: systems biology, quantitative systems pharmacology, microbiology, and nutrition. BugTheDrug conceptually and technologically addresses the demand for novel approaches to the study of individual variability, thereby providing breakthrough support for progress in precision medicine.

Keywords: gut microbiota,nutrition,therapeutic stratification,precision medicine,drug metabolism,human metabolism,colorectal cancer,parkinson s disease,physiology based pharmacokinetic modeling
Fusion-to-Fossil Heat Exchanger for Supercritical Power Plants (F2F)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-05-01
End date: 2016-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Established in 1971, our company LEADING METAL MECHANIC SOLUTIONS S.L. is a Spanish specialist in design, development and manufacturing of precision components (machined, welded, forged or casted). In recent years, we have directed our business strategy to technology and knowledge-intensive sectors – Oil & Gas, Power plants, Airspace and Defense – where we have been continually striving to get involved in highly innovative projects, large-scale scientific initiatives and new materials. We have successfully participated in the ITER project to manufacture the First Wall panels and their associated Super-Efficient Heat Exchanger. After several years of R&D work in efficient heat exchangers, we have developed an innovative “Fusion-to-Fossil heat exchanger” prototype to be integrated in Boiler Circulating Pumps (BCPs). BCPs are indeed a key component for Supercritical Coal Power Plants, which have become the system of choice in most industrialized countries due to their high efficiency (40-45%). BCPs are required in all coal power plants in order to circulate water within the boiler to enhance boiler operation. They are designed for high temperatures and high pressure, and they have the highest power demand (3.5-3.9% of the rated generator capacity) of all the auxiliary devices in a coal power plant. Listening to the power plant and energy market and the evolution of its requirements via our customers, we have identified a clear need in higher efficiency and cost optimization for their products. With our “Fusion-to-Fossil heat exchanger” F2F project, we are offering our existing BCP customers and potential customers in other sectors (e.g. petrochemical) an innovative technology achieving a 10-15% increase in system efficiency and a cost savings of up to 30%. With F2F, we will be able to significantly consolidate our market share in the energy sector (+€24Million of revenues within 5 years of exploitation) while increasing the competitiveness of our EU customers.

Keywords: heat exchanger,efficiency,emissions,carbon reduction,coal power plant,power plant,supercritical,knowledge transfer,manufacturing optimization
Fuse smFRET and modeling to a new structural biology method and solve the functional ESCRT assembly structure (smSTRUCT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 257860.8
EU funding (EUR): 257860.8
Participants: 2
Project status: CLOSED

We seek to develop a new structural biology method that is able to overcome barriers to solving very complex functional protein assemblies that are variable enough in their composition and conformation to defeat current methodologies. I intend to combine high-throughput single molecule FRET (smFRET) experiments with computational modeling to achieve this goal. SmFRET will be used to derive individual building block structures as well as distances between these blocks on a molecule-to-molecule level. Computational modeling is used to fuse this information into a full atomistic model of the protein assembly. The yeast ESCRT machinery is proposed as a model system to develop the new methodology. The ESCRT machinery is particularly important because of its role in HIV infections: HIV seizes control of the cell’s ESCRTs to get released from infected cells. The ESCRT assemblies’ size and flexibility lead to the fact that their assembled structure on membranes is largely unknown. Individual ESCRT proteins will be labeled by Cy3/Cy5. The ESCRT assembly will then be reconstructed on invaginated supported lipid bilayers and imaged via TIRF microscopy. FRET efficiencies will be recorded and the label-label distance determined. High-throughput biochemistry and labeling technology will allow us to generate > 100 distinct labeling sites, resulting in overdetermined structures. Stepwise photobleaching will reveal the stoichiometry within full assemblies. Alterations in FRET efficiency due to local contact formations within the assembly will reveal these local contacts. Based on the experimental data of the individual complexes, their copy number in the assembly and their local contacts, the full assembly will be determined computationally, based on replica exchange Monte Carlo simulations.

Keywords: single molecule fret experiments