Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SUstainability-driven international/intersectoral Partnership for Education and Research on modelling next generation CONCRETE (SUPERCONCRETE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Argentina,Spain,Germany,Germany,Italy,Netherlands,United States,Portugal,Brazil
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-07-01
End date: 2019-06-30
Duration (months): 48.0
Total project cost (EUR): 504000.0
EU funding (EUR): 468000.0
Participants: 10
Project status: CLOSED

SUPERCONCRETE is a synergetic cross-disciplinary international/intersectoral project addressing theoretical models for next-generation concretes, characterised by a significant sustainability enhancement for the construction industry. Three advanced concrete classes (CCs) are selected which represent the projects’ key research lines: - Low-Carbon Concrete (LCC), characterised by non-conventional constituents, often derived from recycling industrial waste or by-products; - High-Class Concrete (HCC), encompassing materials with enhanced performance in strength, durability; - Fibre-reinforced Cementitious Composites (FCC), with special features on fibre/textile reinforcement and matrix improvement. Developing synergetic through-life multi-scale models for these novel materials is the key objective of the SUPERCONCRETE project. Particularly, three transversal modelling issues (MIs) are considered: - Rheology and Early age, dealing with the various physical and coupled thermo-hygro-chemical phenomena taking place in the first hours after mixing; - Hardened state and service life, approached by constitutive modelling intended at predicting the instantaneous and long-term behaviour, for both service and ultimate conditions; - Extreme conditions, based on constitutive theories capable of simulating the response under fire and high temperature exposure. Each CC and MI is covered by one participant and the interactions among them is based on a matrix-like organisational approach aiming at achieving a true synergistic collaboration among those with specific CC knowledge and the ones bringing in transversal competences on MIs. A further cross-cutting objective aims at defining a “Sustainability Index”, based on its constituents and processes requested for each CC. SUPERCONCRETE’s final deliverables will be 1) a joint international course on sustainable concretes with 2) an underlying textbook and 3) a web-based platform for interacting with students and practitioners.

Keywords: sustainability,concrete,modelling,multi scale,multi physics,durability,rheology,service life,extreme conditions,education,knowledge transfer,textbook,international,intersectoral
For a sustainable and european value chain of PHA-based materials for high-volume consumer products (NENU2PHAR)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Spain,Belgium,Poland,Belgium,Croatia,Belgium,France,France,France,France,France,France,Netherlands,Portugal
Call: Develop sustainable bio-based materials for high-volume consumer products (H2020-BBI-JTI-2019, 2019)
Start date: 2020-09-01
End date: 2024-02-29
Duration (months): 42.0
Total project cost (EUR): 6542581.25
EU funding (EUR): 4983169.87
Participants: 18
Project status: SIGNED

Plastic is one of the preferred materials for manufacturing high volume consumer products and more particularly packaging thanks to its physical, mechanical, thermal or barrier properties. However, existing global plastic industry is mainly a petrochemical-based industry, bringing bad environmental footprint. Polyhydroxyalkanoates (PHAs) are a group of biopolymers that are now widely recognized as attractive substitutes to fossil fuel derived plastics in a wide range of applications. Unfortunately, no sustainable value chain exists in Europe, and production schemes developed elsewhere in the world appear highly questionable from an environmental and ethical standpoint. The NENU2PHAR project aims at bridging this crucial gap in the EU industry, within an inclusive approach that will address the whole PHA-based plastic value chain, targeting high volume consumer products. The NENU2PHAR project gathers 17 partners (5 large industrials, 6 SMEs, 5 RTOs and 1 cluster), leaders in the different fields of research, from biomass development to formulation of biopolymer up to plastic processes. First, bio-source will be tackled by developing and optimised production of PHA biopolymer thanks to the optimisation of carbon feedstock from micro-algae biomass and selection of bacteria strains. Then, innovative polymer processing options will generate different structures with various bulk-surface properties, and various end of life properties. Market uptake of this new PHA will be supported by a competitive cost (5€/kg for PHA compounds), high purity product and processes optimised for PHA bioplastic to tackle functional properties of high volume consumer product better than fossil-based counterparts. 8 PHA-based products will be developed and benchmarked to their fossil-based counterparts. Full validation of the end of life scenarios and environmental footprint will be studied based on biodegradability, compostability or recyclability of the bioplastics formulated.

Keywords: polyhydroxyalkanoate,bioplastics,food packaging,plastic process,bioplastic recycling
Prophecy, Public Sphere and Emotions in Late Medieval and Renaissance Tuscany: From Dante to Savonarola (PROPEL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 251002.56
EU funding (EUR): 251002.56
Participants: 2
Project status: CLOSED

In medieval and Renaissance Europe, prophetic discourse was one of the most incisive means for proposing or opposing alternative models of political and religious order. A large number of short prophecies circulated at that time throughout the continent, which have never received a thorough analysis. Because of the outstanding quality and variety of the documentation, Florence and Tuscany offer a perfect starting point. PROPEL will be the first systematic investigation of the circulation of prophetic texts (direct or reported), from all over Europe, in the Tuscan cities, bearing in mind two key figures as chronological limits: Dante Alighieri (d. 1321) and Girolamo Savonarola (d. 1498). The aim of the project is to analyze the entire corpus of prophecies (in Latin or in vernacular, in prose or in verse), which is transmitted by a great variety of manuscripts (flyleaves, fliers, miscellanies) or included in larger texts (chronicles, sermons, encyclopedic works). This philological challenge will be the premise for a new and comprehensive interpretation of prophetic discourse as having a performative nature. In this perspective, the public sphere can be considered the lively theater in which civic identity was at the same time represented and created by prophecies: that is to say, texts which put into play not only ideas, but also strong emotions such as love and hate, hope and fear. The project proposes an unprecedented dialogue between material philology, media studies and history of emotions. This interdisciplinary perspective will change the way in which late medieval and Renaissance prophecy is perceived in available scholarship. Moreover, by reflecting on the ways one-sided information shapes collective identities and future-oriented emotions influence the public sphere, PROPEL will develop a dialogue with journalists and politicians in order to deconstruct and dismantle the intensifying rhetoric of religious extremism, xenophobic nationalism and media violence.

Keywords: prophecy,millenarianism,messianism,manuscript culture,material philology,public sphere,performative discourse,civic identity,emotions,violence
oculavis SHARE: The Remote Service Platform for B2B service processes based on Augmented Reality and Artificial Intelligence Technologies (oculavis SHARE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-08-01
End date: 2022-01-31
Duration (months): 30.0
Total project cost (EUR): 3570312.5
EU funding (EUR): 2499218.75
Participants: 1
Project status: CLOSED

About 20 Million European service technicians, quality managers or know-how carriers travel daily all over the world to support clients for industrial service or troubleshooting. To avoid travel costs, CO2-emissions and machine downtimes by up to 50%, the Software-as-a-Service (SaaS) platform oculavis SHARE offers virtual service functionalities to connect manufacturers with their clients. Even for highly complex tasks technicians can support their clients while staying at home. oculavis SHARE is the innovative Remote Service Platform for the industry, offering company-branded and customizable service apps, ready-to-use Augmented Reality (AR) and Artificial Intelligence (AI) applications. SHARE allows clients to offer digitized service business models in addition to their hardware products. The software is modular and scalable while meeting individual demands by means of configuration. Use-cases covered by SHARE are typical service tasks occurring in complex production environments like troubleshooting, spare parts ordering, remote support, AR-instructions, service chat, ticket requests as well as data and event-based visualizations. Technicians access the mobile apps typically with Smartphones, Tablets or Smart Glasses. Founded in May 2016, oculavis employs 25 persons today. It reached the Top3 of the most important German Founders Award (“Deutscher Gründerpreis 2018”). The company is owned and lead by the three friends Dr. Markus Große Böckmann (34 years old), Philipp Siebenkotten (34) and Martin Plutz (34) and has over 100 SHARE-installations in paid Proof-of-Concept (PoC) projects with enterprises and SME. Projects and software licenses increased the turnover to 1.45 Million Euro in 2018. oculavis applies for this EU-funded project to develop the SaaS-feature for scaling, create a partner ecosystem, implement scalable business processes and to complete the platform with further AI and AR service functionalities.

Keywords: remote service platform,augmented reality,artificial intelligence,digital service business models,smart glasses,customer service processes,maintenance processes
Aquaculture meets Biomedicine: Innovation in Skeletal Health research. (BioMedaqu)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Spain,Italy,Italy,Belgium,Belgium,France,Portugal,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-08-01
End date: 2023-01-31
Duration (months): 54.0
Total project cost (EUR): 3747204.0
EU funding (EUR): 3747204.0
Participants: 9
Project status: CLOSED

Skeletal anomalies in farmed fish are a continuous problem for global aquaculture, affecting fish welfare, performance, and product quality. Aquaculture research has made considerable progress in reducing the incidence of deformities, but new species, intensified production, the damned for sterile fish, delicate early life stages and new fish feed ingredients are a continuous challenge. The use of zebrafish (Danio rerio) and medaka (Oryzias latipes) as models for research into human skeletal diseases such as osteoporosis, osteopetrosis and degenerative joint diseases is increasing, however their potential as models for farmed fish has not been sufficiently explored. These models offer the possibility to obtain deeper insights into the fundamental mechanisms that can cause skeletal malformations in humans and in farmed fish. A framework for communication and scientific exchange between the aquaculture and biomedical sectors would benefit all stakeholders and advance scientific understanding of the problem. We propose a joint inter-sectorial training network to increase the mobility and visibility of scientists between aquaculture research and the biomedical sector using small fish models. The proposed ESR programs will provide career development to young researchers in the field of skeletal biology through international and multidisciplinary training on innovative molecular, histological, biochemical and cell culture methodologies relevant to both sectors. The network combines stakeholders from 7 European Universities, a US research hospital, and one Biological Institute. Commercial interests are represented by two Economy departments, one aquaculture and a major fish feed production company. This structure allows the flow of information and people between the biomedical and aquaculture sectors, and between academic and applied sectors, thus addressing several objectives of the Europe 2020 strategy and ensuring a direct route from knowledge to application.

Keywords: aquaculture,skeleton,anomalies,d rerio,o latipes,fish,nutrition,artificial intelligence,osteopathologies,proteomics,epigenetics,biomechanics,evolution,deformity
Adaptive evolutionary pathways of highly pathogenic avian H5N1 influenza in humans (HAAIV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-11-01
End date: 2017-10-31
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Highly pathogenic H5N1 influenza viruses are endemic in wild birds and poultry across several Asian countries, and continue to cause human infections with high mortality. Global concern persists that these avian influenza viruses will evolve into viruses that can efficiently transmit between humans and may then cause a severe influenza pandemic. However, estimating the real risk of such a pandemic scenario is difficult due to limited understanding of the evolutionary requirements of H5N1 viruses to cross the species barrier and adapt to humans. There is therefore an urgent need to increase our insight into H5N1 influenza evolution within the human host and identify and characterize previously unrecognized adaptive evolutionary pathways. To gain this understanding we propose to apply whole genome, next generation viral quasispecies sequencing directly from serial clinical specimens obtained from H5N1-infected patients. We will perform an in-depth characterization of mutations that are selected during human H5N1 infections and include all influenza virus genes in our analyses. These analyses will provide insight into the diversity of H5N1 quasispecies and the molecular mechanisms of human adaptive mutations. This unbiased whole genome sequencing approach of the dynamics of within-host evolution of quasispecies during the course of infection in serial clinical specimens is highly innovative. The detection of minority variants that expand during the course of infection represents a unique approach to identify adaptive viral evolutionary pathways.

Keywords: influenza virus,h5n1,human adaptation,evolution,transmission,deep sequencing,quasispecies,hemagglutinin
The Remote Control of Maternal Metabolism by the Placenta (PlaEndo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-09-25
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

During pregnancy many physiological changes occur in the mother that are designed to support fetal growth. These include changes in the cardiovascular, pulmonary, immune and metabolic systems. In particular, the mother becomes less reactive to insulin, leading to increased glucose availability to the fetus in late pregnancy. These adaptations are thought to be signaled, in part by changes in placental hormone production. Whilst studies have shown that the placenta has the capacity to produce different hormones, their specific role in adapting maternal metabolism during pregnancy relies principally on association studies. Moreover, there are likely to be more protein mediators secreted by the placenta with systemic actions in the mother. Failure to adjust the mother's body to the pregnant state may result in pregnancy complications, including abnormal birth weight and maternal diabetes, which can further lead to a range of medical complications for the mother and baby. The overall goal of this study will be to identify the nature and wider biological significance of placental endocrine function in adapting the mother's body during pregnancy to support fetal growth, with a focus on maternal metabolism. This work will primarily use the mouse as an experimental model as the placental signaling/secreting cells are conveniently organized into a distinct region and are under unique genetic control. Therefore placental signaling cells can be isolated, cultured and genetically-modified independent of other cells in the mouse placenta. The secreted placental candidates will be identified using the latest sequencing technologies, and their metabolic effects will be tested on cell lines and in the whole organism using unique genetic tools available at the University of Cambridge. Knowledge gained from this study will be the first step in the development of targeted interventions for optimizing fetal growth and preventing pregnancy complications.

Keywords: endocrine secretion,placenta,maternal metabolism,fetal growth support
BETTER TREATMENTS FOR BREATHLESSNESS IN PALLIATIVE AND END OF LIFE CARE (BETTER-B)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Ireland,Italy,Australia,Italy,Switzerland,Poland,Poland,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Novel patient-centred approaches for survivorship, palliation and/or end-of-life care (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 3791503.5
EU funding (EUR): 3769999.75
Participants: 15
Project status: SIGNED

The BETTER-B consortium tests whether mirtazapine, currently used as an antidepressant, is an effective treatment to reduce chronic or refractory breathlessness (CB) in patients with advanced chronic obstructive pulmonary or interstitial lung disease (COPD or ILD) needing palliative care or at the end of life. Our focus is on breathlessness that persists despite optimal treatment of the underlying condition. This widespread and frightening symptom has a major detrimental impact on patients’ quality of life and distresses their family, friends and carers. It is associated with physical and psychosocial morbidity and results in high use of health care services, including emergency care. There are no licenced medicines for CB in the world. It is a major challenge to clinical management, care quality and patient wellbeing. We have completed a feasibility trial in 60 patients, reviews and case studies that suggest mirtazapine is a promising treatment. To assess if mirtazapine is effective, we conduct a randomised double blind clinical trial of mirtazapine versus placebo in patients with CB and COPD or ILD. The trial recruits 324 patients over 18 months across respiratory, palliative care and community services in Poland, Ireland, Italy, Germany and the UK. We study the effects of treatment over time on patients, their family or caregivers and care costs. We survey clinicians and produce accessible European guidance on treating CB. The consortium unites a unique multi-disciplinary group of clinician scientists from respiratory, palliative, geriatric and rehabilitation fields, alongside statisticians, trialists, health economists, health care researchers, patient and consumer groups and a European Society. This ensures the optimal design and operation of the trial and the widest impact from its results. Using an existing medicine for a different purpose offers a highly cost-effective approach for treatment that can be implemented and sustained internationally.

Keywords: palliative care,breathlessness,end of life care,dyspnea,clinical trial,randomised,copd,lung disease,physical and mental health,caregivers,cost effectiveness,effectiveness,guidance