Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Novel integrated experimental and analytical approaches to unravel parasitic interactions by stable isotope analyses (PARAISO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: SIGNED

Parasitic trophic interactions have been largely excluded in food web studies, but recent research has highlighted their integral role in affecting food web properties. Previous efforts to unravel trophic interactions between parasites and their hosts have used stable isotope analysis of whole tissues (bulk SIA, 13C and 15N), but these studies show considerably higher variability in the isotopic differences between parasites and their resources than usually observed for free-living species. This variability, combined with likely effects on the isotopic composition of infected hosts further confound trophic interactions within food webs. PARAISO aims to make a significant contribution to our understanding of parasitic trophic interactions and their potential to affect the isotopic composition of infected hosts through an innovative integrated approach combining field sampling and laboratory feeding experiments with the simultaneous analysis of bulk SIA and compound-specific stable isotope analysis of amino acids (CSIA-AA). This novel technique allows for the detection of changes in individual amino acids during trophic transfer and for comparison of source vs trophic amino acids to identify the trophic level of individual animals. Combining field samplings, laboratory-based feeding experiments with four common coastal parasite-host systems, and the use of bulk SIA and CSIA-AA will allow for determination of isotopic changes caused by dietary shifts or parasitic infections in both hosts and parasites. With this novel interdisciplinary approach using cutting-edge technologies, PARAISO will significantly advance our understanding of trophic transfer during parasite-host interactions. Through successful implementation of this project, the gained skills and dissemination actions will considerably contribute to EU excellence in isotope ecology and ecological parasitology and place the applicant in a powerful position to continue her career.

Keywords: stable isotope analyses,trophic parasite host interactions,feeding experiments,csia aa,bulk sia
Transforming European Women’s Entrepreneurship: The Education and Training for Success Programme (women entrepreneurs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria,Ireland,Germany,Cyprus,Colombia,Chile
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-03-01
End date: 2019-02-28
Duration (months): 48.0
Total project cost (EUR): 679500.0
EU funding (EUR): 679500.0
Participants: 7
Project status: CLOSED

The objective of the women entrepreneurs project is to set up and strengthen international and inter-sectoral collaboration in the research field of competence development in young women entrepreneurs and to promote women’s entrepreneurial potential in Europe. The scientific goal is to get a better understanding of the fundamental entrepreneurial competences and to develop an educational programme to enhance the ratio of successful young women entrepreneurs across Europe. This requires academic and non-academic collaborations and the sharing of knowledge from different areas, e.g. the assessment of essential supporting competences for successful entrepreneurship, the design and provision of the educational programme, and evaluation. The partners will build a robust network covering all research areas and perfectly complement their associated expertise. women entrepreneurs is divided into five work packages (including the work packages of project management and exploitation, dissemination and outreach activities) that will guarantee the establishment of a sustainable long-lasting network. The research objectives range from an analysis of the competences of women entrepreneurs across Europe to the design and provision of a programme that facilitates the entrepreneurial competences and the development of a learning transfer framework. Through participation in events (besides scientific conferences also Researchers Night or Girls Day), the project objectives will be transformed not only into the scientific network, but also further communicated to the general public. women entrepreneurs bears a potential for the commerzialisation of innovations, building upon an exploitation plan. Moreover, the non-academic partners represent characteristic lead users of the project outcomes. We believe we can significantly contribute to the EU Entrepreneurship 2020 Action Plan, with the proposed collaborations and activities strengthening the sharing of knowledge in Europe.

Keywords: entrepreneurship,women entrepreneurs,training and education,learning transfer,meaning making,identity transition
Toward Tough Glasses with Controlled Nanoscale Heterogeneities (GLASSphase)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Specialty glass manufacturing is annually a €30 billion industry worldwide and transparent oxide glasses are one of the most important engineering and functional material families owing to their unique features, such as tailorable physical properties. However, at the same time, intrinsic brittleness continues to be their main drawback, which severely restricts many applications. In the proposed project, we will explore the possibility to improve the fracture toughness and damage resistance of oxide glasses through controlled nanoscale phase separation, as the presence of inclusions can lead to crack deflection or trapping. The size of these heterogeneities needs to be small enough (<50-100 nm) to maintain transparency. To this end, we will tune the composition of calcium aluminosilicate glasses to enable controlled phase separation with respect to the size and composition of the nano-domains (Work Package 1). Then selected mechanical properties (stiffness, hardness, fracture toughness, and crack resistance) of these new glasses will be explored (Work Package 2). These experiments will be guided by a combination of atomic scale (molecular dynamics) and microstructural scale (peridynamics) simulations (Work Package 3). The project will provide the scientific breakthrough for elucidating the toughening mechanism induced by phase separation and its impact on macroscopic crack propagation. The complementary expertise of the applicant and supervisor and the research and training environment provided by the host organization (Aalborg University, Denmark) will ensure the achievement of this timely and innovative project as well as the dissemination and exploitation of the expected results. These research outputs will accelerate the design of new fracture-resistant glasses, which can be used in various fields. The applicant will emerge from the project with new skills, and the capability to launch her own research group.

Keywords: glasses,fracture toughness,structure property relation
The advent of the Iron Age in cell death (IRONDEATH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany,Germany
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 2499835.0
EU funding (EUR): 2451835.0
Participants: 2
Project status: SIGNED

The recognition of distinct regulated cell death pathways presents tantalizing possibilities for gaining control over life and death decisions made by cells to both prevent age-dependent (neuro)degenerative diseases and to fight cancer. For decades, apoptosis has been considered as the sole form of regulated cell death, while others were deemed unregulated, necrotic. In this context, pioneering work originating from my group enabled to establish “ferroptosis” as an iron-dependent cell death modality that is marked by the oxidative destruction of cellular membranes. Ferroptosis has sparked overwhelming interest in the last few years not only because it harbours many pharmacologically tractable nodes, but as it is likely induced only under pathological conditions, thus opening the unique opportunity for a broad therapeutic window of novel ferroptosis modulators. While some of the molecular players, metabolic contexts and respective small molecule inhibitors and inducers of ferroptosis have been recently described, pivotal questions have remained unanswered. In a holistic approach this project is conceived to tackle these fundamental questions by providing answers to (i) whether there are yet-unrecognized key ferroptosis nodes that may explain why certain cells are highly vulnerable to ferroptosis while others are not, (ii) the nature and subcellular compartment where the initial ferroptosis priming signal is being generated and (iii) why certain cells and tissues die by apoptosis while others succumb to ferroptosis. Successful implementation of the herein proposed aims will yield novel ferroptosis regulating genes as potential future drug targets, decipher and localize the death signal affording the rationale design of refined small molecule ferroptosis modulators and enable the precision-based treatment of patients suffering from early cell loss and tissue demise or cancer.

Keywords: ferroptosis,regulated necrosis,lipid peroxidation,redox signaling,cell death,mouse genetics
SHADOWS: Tackling Undeclared Work in the European Union (SHADOWS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Across the member states of the European Union and beyond, paid transactions occur that are not declared to the state for tax, social security and/or labour law purposes when they should be declared. This is not a minority practice and thus tackling undeclared work has become a core issue on the policy agendas of supra-national agencies and governments (European Commission, ILO). Reviewing the literature, it becomes quickly apparent that not only are there two distinct approaches, namely a ‘rational economic actor’ approach that tackles undeclared work by ensuring that payoff from undeclared work is outweighed by the costs, and a ‘social actor’ approach grounded in a view that undeclared work arises when tax morale is low, but also an emergent debate about whether these are complementary or competing approaches. This Fellowship aims to advance knowledge, by evaluating not only the effectiveness of using each approach to reduce undeclared work in different contexts, but also develops new understandings of the most effective overall approach by for the first time analysing interaction effects (between deterrents and tax morale, and vertical and horizontal trust) in various contexts. Considering the ambitious objective of advances a new theory for explaining and tackling the undeclared work, the main focus of the project is to ensure that all four types of triangulation, namely methodological triangulation, data triangulation, theory triangulation and investigator triangulation (interdisciplinary board) are addressed. As such, four extensive datasets are used as well as in-depth interviews in two countries with contrasting contexts of undeclared work (UK and Romania). This project conducted under the supervision of Prof Colin C. Williams, and the Cluster for Research on the Informal Sector and Policy team, will greatly increase our understanding of the undeclared economy and will provide evidence-based policy relevant findings.

Keywords: undeclared work,institutional theory,tax morale,public policy,european union
milkGUARD – a continuous whole milk disinfection system for calf feeding on-farm (milkGUARD)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Denmark
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-05-01
End date: 2017-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The problem: Dairy farms are continuously aiming at increasing milk yield per cow in the herd. Calf early life nutrition dictates their development. Farmers feed a variety of liquid feeds including milk and milk replacers. The state-of-the-art method to reduce the risk of disease spread while feeding milk is to pasteurize it. Though natural milk is the ideal nutrition for calves, the need for pasteurization represents an additional cost of 100,000 €/ year (for a herd with 120 calves). Importantly, on-farm pasteurized milk may still contain measurable amounts of bacteria and the overall procedure is time- and energy-demanding, which hampers wide application amongst small and medium dairy farms. The solution: We at Calvex have developed the milkGUARD solution, which enables the safe employment of optimum nutrition for calves, i.e. natural milk, free of pathogens. The milkGUARD solution combines state-of-the-art methods for fast killing of pathogens in natural milk. In a three-stage continuous process it disinfects milk with an efficacy of 99.99% - 100%. By providing a system that avoids indirect heating elements and works in continuous, we expect to reduce the operating costs to dairy farmers when treating milk for calf-feeding, offering e.g. 30% of energy savings when compared to conventional on-farm pasteurizers. The market: Milk is the EU's main agricultural product in terms of value – approx. 15% of agricultural output – with 160 million tonnes of cow’s milk produced in 2014. The EU milk processing industry is a pillar of the European economy, which contributes positively to the EU trade balance, bringing over €10 billion surplus. The implementation of the innovation project will place Calvex in a strong position to exploit a market potential over five years exceeding €56 million.

Keywords: milk disinfection,calf feeding,pasteurization,energy saving
Artificial Intelligence Powered Fashion Insights and Personal Styling Solutions (RDS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-12-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Radius is a London based fashion technology start-up that has developed the Google Analytics of Fashion Trends. Radius Tech curates real-time insights on the most commercially viable fashion products and trends worldwide. These data analysis and styling recommendation insights help fashion retailers to personalize their product offerings based on consumer’s demographics, lifestyle and fashion style preferences. Radius solutions align with the recent fashion market dynamics that urged retailers to offer a zero-friction shopping experience. Last year experiencing very low conversion rates, 60% of the fashion retailers had cost-reduction in product assortment and increased their spending in e-commerce & customer experience and focused on new technologies to enable a smooth and speedy transition from inspiration to acquisition. There are 37,925 fashion retailers in the United Kingdom alone. Our market research shows that this new increased spending in e-commerce and customer experience has created a €2.54 trillion Total Addressable Market (TAM) globally. In this vast market, Radius is leading the 3rd phase of tech-enabled fashion shopping service providers. Our strength and competitive edge come from the excellence of Radius Tech, unique value propositions and our team’s aggregate experience of 40 years in start-up, AI & computer vision technology and fashion as well as marketing domains. The scope of this project is to finalize the validation of Radius Recommendation Engine that uses curated fashion insights from Radius Tech to automate personalization and evidence based decision-making for fashion retailers.

Keywords: business intelligence,fashion retailers and e tailers
Phase map of dynamic, adaptive colloidal crystals far from equilibrium (Ph.D.)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany,Türkiye
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 918353.75
Participants: 2
Project status: SIGNED

We recently reported the first observation of dynamic adaptive colloidal crystals exhibiting characteristics similar to those commonly associated with living organisms: self-replication, self-healing, adaptation, competition, motility. Here, I propose to do the first experiments to clarify precisely how dynamic adaptive behavior arises far from equilibrium and how to control it. The key to both is a fundamental question at the heart of condensed matter, statistical and nonlinear physics: When far from equilibrium, in the presence of fluctuations and faced with multiple steady states with small energy differences, how does a system evolve? Specifically, my objectives are (1) to form crystals with periodic and aperiodic patterns, e.g. 2D Bravais lattices, quasicrystals, using passive identical particles, (2) to quantify their formation energies through the effective temperature of Brownian particles, (3) to identify the conditions for emergence and control of adaptive behavior. Then, I will draw a complete phase map of these dynamic adaptive colloidal crystals using fitness landscapes to characterize each pattern. I will further ask to what extent this control is extendable down to the few-nm scale, where fluctuations are even stronger and if and how these findings change when using nonidentical, in size or shape, but still passive particles. My system comprises quasi-2D-confined pure-polystyrene 500-nm spheres suspended in water. An energy flux to drive the system far from equilibrium and sustain it there is supplied by an ultrafast laser. My method exploits only three physical tenets, nonlinearity, fluctuations and positive/negative feedback mechanisms acting on identical passive particles, yet generates extremely rich emergent dynamics. A full understanding of how such dynamics arise from so few basic ingredients will advance our understanding of complex systems in addition to numerous practical applications to self-assembly, microfluidics, nanoscience and biology.
BRAIN-ACTUATED SPINAL CORD STIMULATION TO RESTORE GAIT AFTER PARALYSIS (BRAINGAIT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Switzerland
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-12-01
End date: 2021-08-31
Duration (months): 21.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Spinal cord injury (SCI) leads to severe motor impairments that significantly alter the quality of life of affected people and incur substantial cost for families and society. The ideas developed within the framework of our ERC starting and Consolidator grants led to the development of neurotechnologies that restored walking in paralyzed individuals. This treatment involves the delivery of targeted electrical spinal cord stimulation protocols that reactivate the spinal cord below the injury and amplify the residual commands from the brain. Crucial to the recovery of voluntary movements is the temporal coincidence between the location of the stimulation and the residual command from the brain. To achieve a perfect synchronization, we directly linked decoding of motor intention from brain recordings to the modulation of spinal cord stimulation protocols. We validated the therapeutic efficacy of this wireless brain-spine interface in a nonhuman primate model of SCI. Here, we aim to establish the technical and regulatory feasibility of this wireless brain-spine interface in humans, develop additional intellectual property, and prepare the path to the commercialization of this revolutionary neurotechnology.

Keywords: spinal cord injury,brain computer interface,electrocorticogram,clinical study