Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Terahertz magnetoresistive effects in ferro/antiferro/alter-magnetic structures (Tera-MaRs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 207758.16
EU funding (EUR): 207758.16
Participants: 1
Project status: SIGNED

Magnetoresistive effects are pivotal for data storage technologies in modern electronics. Understanding those phenomena at THz frequencies is a crucial prerequisite for the transition of operational speeds from nanosecond to picosecond timescales. Current THz magnetoresistive research has been restricted almost exclusively to ferromagnets. We will reach beyond those conventional materials, where the magnetization dynamics is limited to GHz frequencies, by exploring antiferromagnetic materials which exhibit THz magnetization dynamics. Finally, we will focus on newly discovered altermagnetic materials, which combine the advantageous properties of both, spin-polarized band structure of ferromagnets and THz dynamics of antiferromagnets. We will investigate three key magnetoresistive effects: Anisotropic Magnetoresistance (AMR), Giant Magnetoresistance (GMR), and Spin-Hall Magnetoresistance (SMR) using ultra-broadband THz time-domain spectroscopy. Initially, we will conduct experiments on ferromagnetic structures, which are easy to manipulate with external magnetic fields. Our preliminary results have revealed a never-before-observed time delay of 10 fs in the onset of GMR, corroborating the importance of phase-sensitive measurements. Subsequently, we will focus on antiferromagnetic materials to capture both electron and magnetization dynamics, and ultimately, we will apply the insights to altermagnetic materials. A deeper and more detailed understanding of magnetoresistive mechanisms in THz range will enable the construction of significantly faster and more efficient spintronic devices.

Keywords: magnetoresistance,thz spintronics,thz spectroscopy
A Geological Service for Europe (GSEU)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Coordination and support actions
Countries involved: Belgium,Netherlands,Albania,France,Germany,Spain,Czechia,Ireland,Slovenia,Bosnia and Herzegovina,Italy,Ukraine,Finland,Serbia,Cyprus,Norway,Latvia,Sweden,Denmark,Romania,Switzerland,Greece,Portugal,Lithuania,Luxembourg,Estonia,Slovakia,Iceland,Faroe Islands,United Kingdom,Malta,Croatia,Poland,Austria,Hungary
Call: Support to the activities of the European Geological Services (HORIZON-CL5-2021-D3-02, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 23168128.25
EU funding (EUR): 19106031.0
Participants: 49
Project status: SIGNED

We aim to contribute to the European Green Deal, the UN Sustainable Development Goals and the Horizon Europe objectives through the development of a Geological Service for Europe, which focuses on the planet itself: the earth beneath our feet. The subsurface holds indispensable resources for European industries and opportunities to decarbonise our economy, but also requires careful management to preserve a healthy and safe living environment for Europe’s citizens. Structurally addressing the EU dimension in geological services is needed because the scale of many societally and economically relevant geological features exceeds that of individual countries. Addressing transnational and continental-scale problems requires innovation, standardisation, harmonisation as well as a shared vision. We aim to build the Geological Service for Europe based on Europe’s best practices and implement the Service with the backing of the Union. Existing geological surveys, the national custodians of geological information, have amassed huge legacies of data and information that are difficult to merge. This project will continue the harmonisation and standardisation effort initiated in earlier projects. We aim to create joint services that can support acceleration of the energy and climate transitions, as well as a larger critical mass of intra-European cooperation through convergence of our research agendas, as key steps to increase the amount and quality of results we are aiming for. A common thread in this project is innovation in ways in which subsurface information is conceptualised, organised, visualised, delivered and translated to the needs of a wide range of audiences, and the methodologies to achieve this. Building on the groundwork laid in the GeoERA program, we will scale up and out, not only scientifically, but also in involving national stakeholders in the network, in order to create support and eventually obtain a mandate for a European Service on a permanent basis.

Keywords: critical raw materials,sustainable geo energy,groundwater,coastal vulnerability,offshore windparks,information infrastructure,geological services
Socioeconomic Pathways, Adaptation and Resilience to Changing CLimate in Europe (SPARCCLE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Germany,Belgium,Greece,Poland,Netherlands,Switzerland,United Kingdom
Call: Socio-economic risks of climate change in Europe (HORIZON-CL5-2022-D1-01-two-stage, 2022)
Start date: 2023-09-01
End date: 2027-02-28
Duration (months): 42.0
Total project cost (EUR): 4610787.5
EU funding (EUR): 4610787.5
Participants: 13
Project status: SIGNED

Climate change brings many highly uncertain impacts onto society and economy, and its risks, incorporating vulnerability, require more comprehensive assessments. This requires an enhanced understanding of the interdependencies between climate impacts, adaptation and mitigation measures at high sectoral and spatial granularity, and the temporal evolution and the capacity of the broader socioeconomic context to cope with the climate challenge. SPARCCLE will deliver new, cutting-edge methodological capabilities by advancing and linking knowledge across research communities. Comprehensive assessment of risk will entail production of granular socio-economic data and projections; bottom-up analyses of multidimensional climate vulnerabilities, including under-researched aspects such as gender inequality; high-resolution probabilistic hazards, damages and mitigation-adaptation synergies and trade-offs; top-down integrated assessment frameworks and leading multi-sectoral macro-economic models; socioeconomic analyses incorporating cross-sector and spillover effects and distributional implications. Stress-test scenarios will be deployed for an advanced understanding of the critical climate risks and how they can be managed. Tool and process co-design and co-development with private and public sector stakeholders, including the JRC will enhance exploitation, capacity building and bridge the science-policy-practice gap; all underpinned by established open science data and models and disseminated through various mediums, including online decision-support platforms and public API. SPARCCLE outputs will be guided by the ongoing climate policy ambitions such as Mission Adaptation and EU Green Deal to deliver new insights and decision-making support tools which inform robust climate mitigation and adaptation policy, and contribute to the design of societal transformation pathways of for the EU.

Keywords: socioeconomic change adaptation climate risk integrated assessment mitigation
Physics, Accuracy and Machine Learning: Towards the next-generation of Molecular Potentials (PHYMOL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Poland,Spain,Norway,United States,United Kingdom,Luxembourg,Netherlands,France,Hungary,Germany,Czechia,Switzerland,Canada
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-02-01
End date: 2027-01-31
Duration (months): 48.0
Total project cost (EUR): 2639817.26
EU funding (EUR): 2528157.6
Participants: 23
Project status: SIGNED

Weak intermolecular interactions are the driving force of relevant processes including protein folding, charge transfer through solid state junctions in solar cells and collisions in interstellar gas clouds. Understanding the nature of these forces is essential to achieve better control and optimization of these processes. Nowadays, modelling has become an essential tool for unravelling experiments and aiding materials design. However, the accurate description of weak interactions is plenty of challenges for many theoretical approaches. Atomistic simulations can help decipher the mechanisms underlying complex processes nonetheless precise molecular potentials are required to achieve a quantitative and qualitative description of these physical-chemical processes. Despite the importance of this field, there is, at present, no systematic and comprehensive training in this subject, particularly in the fundamentals of the theory, method development, techniques to rigorously test the theory using experimental data, and the creation of new models using detailed physical understanding combined with machine-learning. The PHYMOL network aims to fill in this fill this gap by bringing together a group of experts in the field of chemical physics, intermolecular interactions, simulation and machine-learning with several industrial and academic partners. This program will exploit the synergies between an accurate description of intermolecular interactions and the use of machine learning techniques towards the generation of new molecular potentials. Combining scientific investigation with an intensive training program PHYMOL will help shape a new generation of researchers with the capability of developing accurate molecular potentials impacting a broad range of applications.

Keywords: electronic structure methods,force fields,molecular dynamics,molecular crystals,empirical models
Highlighting Novel Mechanisms SwaYing ErythroPOietin EXpressIon and RegulAtion (HYPOXIA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-02-03
End date: 2025-06-02
Duration (months): 28.0
Total project cost (EUR): 225904.46
EU funding (EUR): 225904.46
Participants: 1
Project status: SIGNED

Cellular adaptation to oxygen deficiency (hypoxia) is a complex biological process. Germline mutations occurring in the hypoxia genes pathway provided major information to dissect the molecular mechanisms regulating this pathway. The objective of HYPOXIA project is to elucidate the molecular and regulatory mechanisms governing erythropoietin (EPO) gene expression, a major actor of the hypoxia pathway. The originality of HYPOXIA lies in identifying naturally occurring germline EPO mutations in patients with hereditary erythrocytosis presenting excess red blood cells production. Recently, the host laboratory and European collaborators have identified intriguing genetic variants located in non-coding sequences of EPO in six families with erythrocytosis. Remarkably, all families exhibited normal circulating EPO levels, suggesting gain-of-function potentials of the new EPO. EPO is the hormone that regulates daily red blood cells production and its regulation greatly depends on the developmental stage, cellular type, and oxygen concentration. Given the complexity in EPO regulation, HYPOXIA aims at deciphering the expression and splicing mechanism of the newly identified EPO. I will use an innovative cellular disease model based on differentiating human induced pluripotent stem cells (hiPSCs) into different EPO-producing cells (neural crest cells and hepatocytes). The wild-type, edited, and mutant cells will then be studied using Next Generation Sequencing approaches (RNAseq and ATACseq). Besides its erythropoietic role, studies have highlighted various pleiotropic effects of EPO such as its protective role in ischemic injury and wound healing and regulation of metabolic homeostasis including gender-specific EPO response. Thus, HYPOXIA cellular model may lead to the development of new therapeutics or treatments for erythrocytosis, anemia, and other EPO-related disorders. The newly identified EPO isoforms might render this cytokine a promising game changer in human health.

Keywords: hypoxia,erythropoietin,hereditary erythrocytosis,epo producing cells,hipscs,next generation sequencing
Reprogramming of somatic cells into organOids: patient-centred neurodevelopmental disease modelling from nascent induced pluripotency (ReprOids)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 2
Project status: SIGNED

Understanding the neurodevelopmental causes and mechanisms of the brain disease is challenging due to the limited access to the human brain tissues, the complexity of brain anatomy and the lack of accurate models to recapitulate human brain development. The convergence between induced pluripotent stem cell and organoid technology enable to recapitulate key features of early human neurodevelopment disease in vitro. However, the low efficiency, high cost and technical variability of generating induced pluripotent stem cells (hiPSC) and organoids make an impossible challenge to design a powered study for associating patient genotype to organoids’ in vitro phenotypes. I will generate technology to produce human brain organoids from a selected patient in a robust, timely and seamless process and to capture - so far undetected - neurodevelopmental phenotypes. This will be obtained by combining reprogramming to nascent states of pluripotency with neurodevelopmental morphogenesis in three-dimension. Starting from a single nascent naive hiPSC, we will develop a process to form an epiblast cyst, then neuroepithelial cyst and forebrain organoid in continuous three-dimension process. I will use this technology to investigate genetic and epigenetic modifications in the early phase of neural development of Fragile X Syndrome (FXS). We will generate brain organoids from large cohorts of FXS patients for: i) profiling the whole spectrum of in vitro phonotypes associated with the variety of patient’ genetic and epigenetic modifications; ii) revealing unexplored developmentally regulated mechanisms; iii) design a powered study to assess targeted therapeutic options in FXS. ReprOids will allow the generation of human brain organoids from large cohorts of patients capturing in vitro the whole spectrum of disease manifestations. This will have huge impact in patient clinical management at the diagnostic, prognostic or therapeutic level.

Keywords: pluripotent stem cell,reprogramming,organoid
Symmetries in Quantum Gravity (SymQuaG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 1489823.0
EU funding (EUR): 1489823.0
Participants: 1
Project status: SIGNED

Throughout the history of physics symmetries have played a pivotal role. In recent years our understanding of them has been revolutionized to include their action on extended, rather than point-like, operators, called generalized symmetries. So far, however, they have mainly been discussed in theories without gravity. In this project I will take on this important challenge and derive universal constraints on theories of quantum gravity with generalized symmetries. This combination of generalized symmetries and universal properties of gravitational systems allows to utilize the remarkable recent progress in both fields to provide insights into the hitherto unknown laws of quantum gravity, their manifestation in our Universe, and their implications at low energies. Applying these new laws to supersymmetric theories, I will show that all consistent low-energy supergravity theories necessarily have a string theory origin. I will further apply the constraints to restrict phenomenological models describing the dynamics of Nature. The key strategy of my proposal is to investigate the gauging and explicit breaking of generalized symmetries, required by the absence of global symmetries in quantum gravity. Gauging demands the absence of anomalies, which would break the symmetries via quantum effects. I will classify these for generalized symmetries including the presence of quantum gravity fluctuations of the underlying spacetime manifold. The breaking of symmetries requires the inclusion of new objects, whose structure, properties, and applications I will explore systematically. Both, the classification of these general anomalies as well as the classification of symmetry-breaking objects uses the mathematical formalism of bordism groups. Generalizing these to include localized degrees of freedom, SymQuaG uncovers a full web of novel anomalies in order to derive universal consistency constraints, which are then tested in the laboratory of string theory and beyond.

Keywords: generalized symmetries,anomalies,quantum gravity,string theory,swampland
Testing Program Analyzers Ad Absurdum (MirandaTesting)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 1499991.25
EU funding (EUR): 1499991.0
Participants: 1
Project status: SIGNED

Program analyzers act as guards for ensuring reliability of modern-day software. But who guards the guards themselves? Due to their high complexity and sophisticated algorithms, analyzers are likely to contain critical bugs, which we define as those leading to wrong results, e.g., returning `correct' for incorrect software. Such bugs may have detrimental consequences, especially in safety-critical settings. It is, therefore, imperative to be able to detect them. Verifying the absence of critical bugs in a program analyzer is prohibitively expensive. Contrary to verification, automated test generation can be used to effectively find such bugs. Existing testing approaches, however, are still in their infancy for this application domain. To address this issue, MirandaTesting will develop the first principled methodology for testing a wide range of program analyzers. At its core, our methodology exposes more information about why an analyzer computes a particular result; it then uses this information to interrogate the analyzer aiming to force it into a contradiction, thus revealing a critical bug. The project has the following goals: 1. Design a general framework for testing program analyzers using the MirandaTesting methodology; 2. Develop interrogation strategies pertaining to eleven prevalent classes of program analyzers; 3. Demonstrate the effectiveness of concrete instantiations of the general framework and interrogation strategies for several popular program analyzers from each class; 4. Focus on disseminating our methodology and infrastructure. If successful, MirandaTesting will enable systematic testing of entire program-analyzer classes. As a result, analyzers will exhibit fewer critical bugs, potentially preventing catastrophic outcomes in safety-critical domains.

Keywords: automated testing,program analysis,formal methods
The micro-foundations of macro-institutions: an empirical investigation of the co-evolution of populist rhetoric and organizations (MICROPOPULISM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

MICROPOPULISM aims at providing an in-depth analysis of the micro-foundations of populism in order to gain a granular understanding of populist rhetoric that can undermine European values, as well as the drivers of this rhetoric and its economic consequences. Management scholars have made progress in understanding the co-evolution of organizations and institutions. Their contributions only peripherally touch upon macro-institutions and ignore the rhetoric element of institutional change. I want to fill this gap and provide a better understanding of how organizations construct macro-institutions, and to conflate co-evolution theory and discourse analysis. This research project takes plays in the context of populism and multinational enterprises (MNEs): MNEs are powerful organizations that shape globalization forces and economic developments. Populism defines political institutions and contains a central rhetoric element as populists frame the political debate. I will delve into discourse analysis and the rhetoric of populists to accommodate the varieties of their ideas. The analysis of speeches, press releases, or social media posts of populists should enlarge the comprehension of the micro-foundations of macro-institutions, and allow for an integration of discourse into co-evolution theory. I will also draw on hierarchical-linear modelling to explore the co-evolutionary causalities between organizations and macro-institutions. MICROPOPULISM will last 24 months and will be conducted at Luiss Guido Carli (Italy) under the supervision of Prof. Antonio Majocchi, an expert in institutions, MNEs, and economic performance. Luiss focuses on political science and management studies and is an ideal institution for accommodating the interdisciplinary nature of this research project. Results of this project are relevant for different societal groups and will thus be disseminated and communicated to the academic community, policy makers, industry, and general public.

Keywords: populism,mnes,institutions,co evolution