Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DDRNA-based cancer therapy targeted telomeres (DDRNA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-06-01
End date: 2016-11-30
Duration (months): 18.0
Total project cost (EUR): 149425.0
EU funding (EUR): 149425.0
Participants: 2
Project status: CLOSED

The so-called “DNA damage response” (DDR) is a coordinated set of evolutionary-conserved events that, triggered upon DNA damage detection, arrests the cell-cycle and attempts DNA repair. Recently, we have unveiled and reported that DDR activation depends on RNA. We observed that DNA double-strand breaks (DSBs) trigger the local generation of small non-coding RNAs at the site of DNA damage carrying the sequence surrounding the damaged site. These DDR RNAs (DDRNAs) are essential for DDR activation: removal of DDRNAs by RNAse A treatment of permeabilized cells inhibits DDR activation and DDR can be fully restored by the addition of chemically-synthesized DDRNA carrying the sequence surrounding the damaged site but not other sequences (Francia, Nature 2012). Cancer cells must preserve unlimited proliferative potential. We have previously shown that oncogene activation (and therefore cell transformation) is associated with DDR activation at fragile sites (Di Micco, Nature 2006). Several studies have shown that RNA functions can be inhibited by antisense oligonucleotides (ASO) that act by pairing with target RNAs. We propose scientific development and commercialization activities to bring to a clinical application a therapeutic approach for tumors based on DDRNA inhibition by ASO. Analysis of prior art indicate that there is no overlapping IP protection. Based on our solid IPR, we trust we have an excellent candidate for a first-in-class tool to block proliferation in a subtype of tumors.

Keywords: dna damage response ddr,non coding rna,dna damage response rna ddrna,cancer
Reproducible synthesis of nanocrystals with tunable properties for sustainable energy solutions (NANO-TUNE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

The future of materials chemistry is the ability to tune materials properties to meet the demands of specific applications. Nanocrystals (NC) are promising materials because their properties can be tuned with NC diameter. Further tuning can be achieved with materials like non-stoichiometric Cu2S that have tunable properties by incorporating different elements into their structure. One example is Cu2ZnSnS4 (CZTS), a photoabsorber with a tunable band-gap with changes in Cu:Zn ratio. However, in order to take advantage of tunable properties the copper chalcogenide NCs must be made reproducibly. However, the ability to reproducibly synthesize NCs has not been reached due to three challenges. The first is a lack of understanding of the NC nucleation mechanism which results in batch-to-batch variation in NC size. The second is a lack of understanding of NC growth mechanisms and how those depend on growth conditions. The third is phase segregation and cation disorder which often occurs for complex ternary and quaternary materials (like CZTS) synthesized with multiple metal precursors. Studying NC formation mechanisms using in situ X-ray total scattering from synchrotron sources allows for previously unobtainable insight on structure of NCs from precursor to nuclei to NC. In NANO-TUNE, I will study the nucleation and growth of CuS using in situ X-ray total scattering and target subsequent cation exchange with Zn and Sn to make CZTS. The outcomes of NANO-TUNE will be the ability to make NCs more reproducibly and with a great tunability of materials properties. CZTS NCs will be used as a proof of concept to study other copper chalcogenide materials in the future which have a wide range of uses including batteries and sensors. The supervisor of this work, Prof. Jensen, has extensive expertise on studying the structure of ultra-small particles and in situ beamline X-ray total scattering experiments, making the University of Copenhagen the perfect host for this project.

Keywords: nanocrystals,total x ray scattering,pair distribution function analysis,in situ,cuznsns,nucleation,growth,magic sized clusters
Designer enzymes featuring unnatural amino acids as catalytic residue (DENZUAC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 2499996.0
EU funding (EUR): 2499996.0
Participants: 1
Project status: SIGNED

Biocatalysis is a key component of the transition towards a more sustainable and “greener” chemistry. Surprisingly, natural enzymes use only a relatively small section of “reaction space”, that is, only limited number of reaction classes. This in marked contrast to the vast reaction space available to the synthetic chemist. Therefore, it is highly desirable to have enzymes available for the catalysis of these abiological reactions. With the advent of robust expanded genetic code methodologies, it is now feasible to introduce a wide variety of unnatural amino acids into proteins. We envision that the time has come to use this breakthrough technology to create enzymes that contain abiological reactive groups as catalytic residue, for the catalysis of reactions that are not possible using canonical amino acids only. The global aim of this project is the creation and application of designer enzymes with genetically encoded unnatural amino acids as catalytic residue for novel and new-to-nature catalysis. The following research objectives are key to achieving the overall aim: 1. Achieving incorporation of unnatural amino acids containing organocatalytic side chains in proteins. 2. Creation of a library of novel designer enzymes containing unnatural amino acids as catalytic residue. 3. Application of these designer enzymes in catalysis of important reactions that have no equivalent in nature. 4. Directed evolution of designer enzymes featuring unnatural amino acids as catalytic residue. 5. Application of designer enzymes containing UAAs as catalytic residue in biocatalytic cascades. This highly ambitious project combines frontier chemical and biochemical research and will deliver completely new classes of enzymes that can access new and previously unexplored parts of biocatalytic “reaction space”. In this way, this project will contribute to achieving the important societal goal of achieving greener and more sustainable approaches to chemical synthesis.

Keywords: biocatalysis,designer enzyme,unnatural amino acid,expanded genetic code,stop codon suppressionenantioselective catalysis,directed evolution
Me-Check - Screening of the dry eye syndrome (Me-Check)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-01-01
End date: 2019-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Me-Check is a unique innovative Ophthalmic device that allows screening of dry eye and meibomian glands. It is a product developed entirely by Espansione Marketing Spa. Me-Check can define in 3 minutes if the patient is affected by dry eye or not. The purpose of screening is prevention, and it aims to identify people at high risk of a disorder. Dry Eye (DE) syndrome is the most common ophthalmic manifestation and untreated dry eye can cause increased risk of ocular infection, corneal ulcer, and blindness. The clinical diagnosis of DE is challenging due to extensive variety of signs and symptoms and the ambiguity in the etiology and pathophysiology of the disease. The proposed solution introduces novelty and added value: thanks to its best performance Me-Check is a very innovative medical device to screen the eye. Me-Check overcomes the limitations shown by traditional methods and delivers tangible and direct benefits to its end-users: It allows to do a complete automatic and objective screening: in 3 minutes it is possible to define if the patient has the dry eye. It allows to reach a specific results, indeed the device gives two fundamental indications: 1. Meibomian gloss disfunction level (Meiboscale Dr. Pult ) and 2. The eye dry gravity level (OSDI 6 Dr. Pult / Prof. J. Wolffsohn ). The device does not require specific skills of dry eye pathology indeed the property software indicates the pathology level. This method can be used by the ophthalmologists for their routine examination. It is a very easy to use method: it can be used on customer slot lamp, with freehand or with dedicated station. Me-Check addresses the needs of a large B2B user base including 370.000 in EU-28 among subjects responsible for eye disease visits and treatment. All have these main needs: it is instead necessary to evaluate the "risk of dry eye" throughout the population. Me-Check’s Total Addressable Market (TAM) is 925 MEUR in EU 28.

Keywords: screenings,social economics,prevention,dry eye syndrome,opticians,optometrist
Grey and green in Europe: elderly living in urban areas (GRAGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ukraine,Germany,Italy,Italy,Finland,Greece,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2014-12-01
End date: 2018-11-30
Duration (months): 48.0
Total project cost (EUR): 828000.0
EU funding (EUR): 828000.0
Participants: 13
Project status: CLOSED

The EU has to face many challenges in achieving a more balanced regional development and sustainable economic recovery. Many of those challenges have to do with the ageing population trend, urbanization and environment under distress. More liveable and efficient communities is a target to be reached in Europe, where the “silver hair” trends can become a challenging opportunity, from a social, economic and cultural perspective. Despite those challenges are strongly interlinked, solutions provided in urban contexts not often pay due attention to the social process underlying urban trends and to the needs and behaviour of elderly citizens. GRAGE intends to contribute to fill this gap, developing winning ideas to promote an active, harmonious and inclusive citizenship for elderly people living in urban contexts. The consortium gathers ground-breaking expertise from different scientific background (legal, economic, humanities, engineering), from academic and non academic institutions, belonging to several countries (from EU and Ukraine). Using a mix of methodologies, the research and innovation programme of the project will evolve around the idea of citizenship as a collector of interest, healthy environment and suitable urban solutions for an aging society. Main themes will be: green buildings, food and urban agriculture, information and language technology. Researcher will analyze their role in transforming cities in environments that support green and healthy lifestyles for elderly people. GRAGE intents to boost dialogue through Europe, both strengthening the academic and non-academic collaboration and a practical understanding of elderly living across Europe. Such a cooperation can have a series of returns for Europe, ranging from a more effective solution to strategic challenges (sustainable cities and demographic change) to new business opportunities for European firms, offering solutions and products for smart/inclusive/ageing societies at global level.

Keywords: urban agriculture,language and ict,food,green buildings,citizenship
Energy and charge transfer nonadiabatic dynamics in light-harvesting molecules and nanostructures (DYNAMO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-06-01
End date: 2020-05-31
Duration (months): 60.0
Total project cost (EUR): 1501187.5
EU funding (EUR): 1501187.5
Participants: 1
Project status: CLOSED

The goal of DYNAMO is to develop an efficient mixed quantum-classical methodology for the simulation of light-induced nonadiabatic processes in multichromophoric light-harvesting assemblies and to apply it to explore energy and charge transport dynamics in novel classes of light-harvesting systems. There is growing evidence that nonadiabatic relaxation processes play a fundamental role in determining the efficiency of the excitonic transfer or charge injection. In addition to the intramolecular nonradiative transitions through conical intersections, well known from photochemistry, the coupling between the chromophores in multichromophoric assemblies gives rise to novel intermolecular nonadiabatic relaxation channels through funnels between the delocalized excitonic and/or charge transfer states. In order to simulate coupled electron-nuclear dynamics in multichromophoric nanostructures we will develop and implement light-induced surface hopping methods and combine them with efficient electronic structure methods. For a unified description of excitonic and charge transfer states we will combine constrained density functional theory (CDFT) and linear response time-resolved density functional theory (TDDFT) within the configuration interaction framework. The direct link with the experiment will be provided through the simulation of time-resolved multidimensional spectra in the mixed quantum-classical framework. We will apply the new methodology to investigate energy and charge transport in nanostructures of self-assembled organic molecules (e.g. tubular J-aggregates), in low band-gap organic polymers (e.g. squaraines) and in hybrid plasmon-exciton architectures, where the photon capture and charge injection efficiency can be enhanced by the interaction with plasmonic fields. The ultimate goal is to reveal mechanisms of efficient energy and charge transfer using a first principles methodology, providing guidance for the design of efficient light-harvesting systems.
TOWARDS RESEARCH EXCELLENCE AND INNOVATION CAPACITY IN STUDING LAKE ECOSYSTEMS FUNCTIONAL STRUCTURES AND CLIMATE CHANGE IMPACT (TREICLAKE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Estonia,Finland,Denmark
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 899750.0
EU funding (EUR): 899750.0
Participants: 3
Project status: SIGNED

Within the field of aquatic ecology, the Estonian University of Life Sciences (EMU) through the Chair of Hydrobiology and Fishery and Centre for Limnology (CL) has steadily improved its ability to describe the ecological processes in Estonian lakes. However, in order to reach the next level in terms of scientific excellence and broader impact within the scientific community, it must move beyond just describing ecological processes in the regional (Estonian) scale. Application of more innovative and advanced methods of experimentation as well as sound experienced guidance for data analysis, scientific writing and presentation would lead CL researchers to be able to develop new paradigms for freshwater ecosystems in general, and specifically in shallow lakes that prevail in Estonia and also globally. However, limitations in staff training and institutional capacity and modest participation in cooperation networks has hindered EMU’s CL from making this jump. Through this cooperation and knowledge exchange, EMU will greatly improve its use of existing research methods as well as develop cutting-edge new approaches that will help EMU to make significant contributions to our understanding of lake ecology and its effects on the environment. The collaboration will also help EMU translate scientific expertise into a greater impact in the international scientific community via publishing of articles and participation in conferences and International projects. The collaboration will also be directed towards improving the education provided to students at all three levels (BSc, MSc, PhD) within EMU by offering new courses and opportunities to study with partner institutions. TREICLAKE will also help EMU to disseminate and exploit research results to audiences beyond the scientific community. This includes policy makers, youth and the general public, to improve understanding of the importance of the topic, including the role that lakes can play in addressing climate change.

Keywords: scientific excellence,freshwater ecosystems,climate impact,aquatic food webs,innovative,research methods,modelling,lake ecology education,public awareness,exploitation of research
For a rapid transition to Smart Grids (GridEye)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Switzerland
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2017-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The proliferation of prosumers and the increase of DERs (distributed renewable, e-mobility, etc.) in distribution grids cause numerous problems to DSOs such as grid instability and supply insecurity, lack of visibility, and difficulty to manage and plan an ever growing grid. So far, unlike high voltage transmission system operators (TSOs), it has not been essential for DSOs to monitor their grids because of the unidirectional power flows and the over-sizing of these grids infrastructures that have allowed to operate them in a safe way. By the increase of DERs and without monitoring systems, it is difficult for DSOs to ensure the reliability and the quality of services while maintaining a limited cost for the grid infrastructure investments. A Smart Electricity Grid is an upgraded active electricity network including information and communication technologies, advanced control, IoT, etc. It can intelligently integrate the actions of ‘prosumers’ able to produce electricity as well as consume it. A smart grid ensures an efficient, sustainable electricity supply, with lower losses and greater reliability and security and solves the main problems associated with the integration onto the conventional distribution network of a great deal of variable and/or intermittent DERs. GridEye allows the rapid transition from the conventional low-voltage grid to a smart distribution grid. GridEye is a true network optimization platform, measuring, monitoring and controlling the low-voltage grid for an efficient integration of DERs. GridEye platform is made up of distributed inter-connected smart modules that measure network quantities and take expert actions to guarantee network power quality and optimization of energy flows. GridEye has been developed by DEPsys a Swiss SME that provides solutions to overcome new constrains associated with the evolution from long-established centralised power systems to modern, sustainable, reliable and decentralised ones.

Keywords: smart grid,distributed energy resources ders,distribution grid,distribution system operator dso,sensitivity analysis algorithm
Intelligent Hybrid Thermo-Chemical District Networks (H-DisNet)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Research and Innovation actions
Countries involved: Germany,Switzerland,Belgium,Belgium,Netherlands,United Kingdom
Call: Technology for district heating and cooling (H2020-EE-2015-2-RIA, 2015)
Start date: 2016-06-01
End date: 2019-12-31
Duration (months): 43.0
Total project cost (EUR): 2699895.0
EU funding (EUR): 2009697.5
Participants: 8
Project status: CLOSED

The innovative thermo-chemical (TC) network technology of H-DisNet will contribute to next-generation district energy networks. The technology will exploit high chemical potential of absorption processes for loss-free transport and storage of energy potential. It will be applied to form an intelligent district network with thermal, electric and gas networks. This intelligent thermo-chemical district network will significantly - increase energy efficiency of heat transport and storage, - increase utilization of waste heat and renewables at low temperature - contribute to a wider usage of district networks by allowing heating and cooling in one multifunctional network and by adding the additional services drying and humidity control. - reduce the primary energy usage The project will serve to gain the required knowledge about processes, components and network applications and to demonstrate the feasibility to allow the industrial R&D to pick up the technology and to bring it to the market. Four project work levels guarantee to reach the readiness for broad industrial development: (1) The partners develop the TC components and intelligent network technology and demonstrate it in a residential area and in an industry environment to proof the technology's feasibility. (2) Modelling of TC components serves to carry out simulation of networks. On this basis, smart control strategies and a network identification tool are developed. (3) Based on simulation, an economic and environmental assessment determines the potential of the technology and allows defining the path to market. (4) The dissemination and exploitation strategy operates at two levels: First, it informs a broad audience including energy suppliers, operators, local governments, manufactures and end users about the principles and benefits of the technology. Second, it enables further development of the technology by generating a stakeholder network with the outlook of a full-scale pilot implementation.