Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Global encounters: Fashion, culture and foreign trade in Scandinavia, 1500-1630 (TRADE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-03-01
End date: 2015-02-28
Duration (months): 24.0
Total project cost (EUR): 298932.6
EU funding (EUR): 298932.6
Participants: 1
Project status: CLOSED

This study of early modern Scandinavian clothing, fashion and textile trade offers a better understanding of how international trade and global cultural encounters shaped Scandinavian cultures in the Renaissance period. Using empirical and material evidence it explores what economic, social and stylistic changes were introduced by foreign imports in Scandinavian clothing cultures, how the lives of individuals were visually transformed by novel concepts, and, eventually, what constituted Scandinavian ‘fashions’ in the period (1550-1620). Carried out at the Centre for Textile Research (CTR), Copenhagen, the central goal of the project is to develop a new methodology combining my previous experience of empirical evidence and theoretical models drawn from fashion theory, social and economic history and anthropology with the tradition of textile analysis and costume conservation. This involves training in technical analysis of textiles, language and palaeographic skills and museum work. The CTR provides an exceptional environment for research and career development, because it holds an extensive international network of scholars and museum partners as well as a strong methodological expertise in textiles at both theoretical and practical levels. The new research perspectives and object-based methods gained at the CTR will result in a series of dissemination activities addressed both at the academic and general public, including scientific publications, an exhibition concept, visiting lectures, internet blog and a mini-conference that draws my own networks at CTR. Denmark has a long tradition of the study of historical dress. Training within the dynamic research environment of the CTR and Danish museums provides me with the research and management skills that, supported by a management course offered by the University of Copenhagen, will allow me to gain an independent senior academic position. My ambition is to found a Centre for Fashion Studies in Helsinki in 2015.

Keywords: fashion,dress,early modern,textiles,trade,scandinavia
Mechanisms of deaminase-independent inhibition of HIV infection by APOBEC3 proteins (MDIIHIVIA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IIF, 2012)
Start date: 2013-05-01
End date: 2015-04-30
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

The human immunodeficiency virus (HIV) continues to be a major public health issue. Current treatments can slow down disease progression, but high costs, severe side effects and the emergence of drug-resistant strains all call for the development of new treatment regimes. The detailed understanding of virus-host interactions is of utmost importance for this endeavor. The cytidine deaminase APOBEC3 (A3) proteins, and in particular APOBEC3G (A3G), are potent host restriction factors that can be packaged into assembling HIV-1 virions and severely compromise viral infectivity. To evade this powerful restriction, HIV-1 relies on the vif (viral infectivity factor) protein, which has evolved to promote proteasome-dependent A3G degradation. Despite intensive research and the high potential of the vif-A3G axis for therapeutic intervention, the precise mechanisms of A3G packaging and HIV inhibition are not fully understood. As a polynucleotide editing enzyme, A3G induces hypermutation in the viral genomic DNA. Additionally, it has recently become evident that A3G also interferes with the process of reverse transcription in a deaminase-independent way. The research proposed here is designed to elucidate the molecular basis of A3G-mediated inhibition of cDNA synthesis during reverse transcription using a combination of experimental approaches and systems. This involves: 1) The assessment of reverse transcription efficiency in the presence and absence of A3 proteins in vitro as well as in physiologically relevant human CD4+ T cells. Importantly, this will include a novel assay designed to map 3’ termini of nascent viral cDNA products. 2) Mapping of A3G binding sites on viral genomic RNA and identification cellular RNA binding partners using CLIP (crosslinking and immunoprecipitation) assays. 3) A detailed investigation of A3G’s interaction with components of the reverse transcription complex (RTC).

Keywords: l601 innate immunity,l611 prevention and treatment of infection by pathogens,hiv,reverse transcription,l101 molecular biology and interactions,l608 virology
A zebrafish model of pancreatic neuroendocrine tumor to test resistance to antiangiogenic compounds (AZNETAC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-07-01
End date: 2015-06-30
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Neuroendocrine tumours (NETs) consist of a range of rare neoplasms that may arise from any (neuro)endocrine cell situated in any part of the human body. Despite the recent approval of two new drugs (sunitinib and everolimus) for pancreatic NETs, innate resistance is frequently encountered in these tumours and patients showing a response invariably relapse due to acquisition of resistance. Moreover, while new data are being generated, including publication of the exome sequence of pancreatic neuroendocrine tumours, the mechanisms of resistance to angiogenesis compounds have not yet been completely elucidated. Data from animal models are scarce about resistance mechanisms to antiantiogenesis compounds in NETs. The zebrafish has recently emerged as an invaluable model system for the study of human cancers. Our main aim is to establish a new zebrafish model for neuroendocrine tumours that can be used to investigate resistance mechanisms to antiantiogenesis compounds. The main hypothesis of our proposal is that we will be able to develop an autochthonous transgenic model of pancreatic neuroendocrine tumours in zebrafish and combine this with the already established kdrl-eGFP transgenic zebrafish line with blood vessels expressing a green fluorescent protein. The objectives of the study are: 1. To engineer an autochthonous transgenic zebrafish model of neuroendocrine pancreatic tumours. 2. Couple the above model with zebrafish possessing GFP-marked blood vessels. 3. Test the activity of known antiantiogenesis compounds such as sunitinib and novel ones in the model generated. 4. To establish lines of fishes resistant to antiantiogenesis drugs. Angiogenesis being a complex and dynamic process, the in vivo study of acquired resistance in tumours and accompanying alterations in tumour vasculature will hopefully give us a better understanding of how sensitive NETs turn into resistant ones.

Keywords: l406 cancer and its biological basis,angiogenesis,drug resistance,neuroendocrine tumors,animal model,zebrafish
Improving risk assessment in environmental decision making through robust uncertainty estimation (IMPROVE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-05-01
End date: 2015-04-30
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Close to three quarters of Europeans think that the EU should propose additional measures to address water problems in Europe. Increasing impacts of human-induced changes on our climate and our landscape threaten important freshwater-related ecosystem services and functions, while the pressure to water security for society increases. Uncertainty in environmental model predictions limits the value of model-based information for characterising and managing water resources both under current conditions and for scenarios of potential future changes. Robust hydrological predictions with minimum uncertainty are needed to support the development of water-management strategies that minimise socio-economic risks at local, regional and global scales. The overall purpose of this project is to improve risk assessment in environmental decision making through robust quantification, reduction and communication of uncertainties in model predictions. A novel framework connecting local and regional information will be developed and evaluated for prediction of water-resources availability under current and changing conditions. The approach combines for the first time a suite of local environmental models (tailored to local conditions), regional understanding on catchment functioning (to constrain model behaviour) and local spot measurements (of key variables in key locations and time periods) in an integrated uncertainty framework. Optimal merging of these information sources for different hydro-climatic and data-availability conditions will be evaluated for regions in the UK, Sweden and Italy, and applied to design cost-effective data-collection strategies at ungauged sites. Optimal strategies to communicate the uncertainty in the predictions to decision makers will be investigated in collaboration with experimental psychologists. Successful execution of this research would create a novel framework for environmental predictions applicable across the world.

Keywords: v101 environment and sustainability,v201 hydrology - water and soil pollution,uncertainty analysis,risk assessment,environmental modelling,decision making,monitoring,water resources
Behaviour, Pollutants and Genomics: exploring their interactions in a fish model (BEPOLGEN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-06-01
End date: 2015-05-31
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

Aquatic habitats are increasingly exposed to chemicals that, even at low levels, can disturb the endocrinology of organisms. These endocrine disrupting chemicals (EDCs) can have severe impacts on reproductive physiology, yet knowledge of their effects on evolutionary processes and population viability is fundamentally lacking. Using the invasive mosquitofish Gambusia holbrooki, the Fellow will use behavioural and genetic assays to reveal how EDCs impact reproductive success and sexual selection. This study will be the first to examine the effects of EDCs on both female and male reproductive behaviour and quality of offspring. Crucially, in a novel approach, cutting-edge, Next Generation Sequencing (NGS) will be used to explore EDC-induced changes in gene expression in the Central Nervous System. The Fellow will expose mosquitofish to 17α-ethynyl estradiol (EE2), a synthetic estrogen used in oral contraceptive pills, and experimentally determine how exposure affects fish reproductive behaviour, reproductive success and gene expression. The Fellow will establish transcriptomic profiles of the fish brain, ovary or testis with NGS and use digital transcriptomics to analyse the effects of EE2 exposure on gene expression. The identity and extent of change of the differentially expressed transcripts will be interpreted with respect to the observed behavioural changes. This study will deepen our knowledge on the genetics of how organisms adapt to human-induced environmental changes and provide evidence on how genome and environment interact. The joint programme of research and training will allow the Fellow to use her existing expertise in behavioural ecotoxicology and critically to engage with new techniques. The programme will give the Fellow competencies in research-related activities and state-of-the-art NGS and bioinformatics that are essential to her in becoming an independent scientist able to command her own research funding and supervise a research team.

Keywords: endocrine disrupting chemicals,sexual selection,reproductive behaviour,genomics,next generation sequencing,ngs,bioinformatics,mosquitofish,invasive species,environmental contaminants,fish
“Adaptation to cyanobacteria through the symbiotic microbiota in the waterflea Daphnia” (ANSWER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2014-01-01
End date: 2015-12-31
Duration (months): 24.0
Total project cost (EUR): 177000.0
EU funding (EUR): 177000.0
Participants: 1
Project status: CLOSED

Metazoans are ubiquitously associated with microbial symbionts, which can provide direct benefits to their hosts, such as nutrients provisioning, protection against environmental stress, or enhancement of host digestive abilities. These microbial mutualists have the ability to adapt rapidly to changing environments, and could potentially play a key role in the local adaptation of their host, especially in the context of rapid environmental changes imposed by human activities. However, despite their potential key role, symbiotic interactions are rarely considered in the study of adaptation. Here, I propose to adopt such innovative approach, using the water flea Daphnia and its microbiota as a model system. This cosmopolitan freshwater crustacean zooplankter has to deal with anthropogenic induced aquatic habitats changes, more particularly with eutrophication and the associated proliferation of cyanobacteria that produce toxic substances. My aim is to elucidate to what extent symbiotic microbial communities (SMCs) are involved in Daphnia adaptation to such stress, and more particular which microbial genes are involved, using a candidate gene approach. In addition, I propose to investigate the consequences of modifying SMCs on host stress responses at the molecular level, by determining whether the expression of particular tolerance genes towards cyanobacteria in Daphnia are dependent on the type of SMC they harbor. If successful, this project will provide some insight into the consequences of human activities for the functionality of SMCs, and into the role of SMC for host adaptation, which might have important implications in different fields, ranging from ecology and evolution to ecotoxicology, conservation biology and medicine.

Keywords: symbiotic microbial community,host adaptation,functionnal genes,daphnia,microcystis
STABLE ISOTOPES OF METALS AS POLLUTANT TRACERS IN THE ATMOSPHERIC ENVIRONMENT (ISOTRACE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Start date: 2013-10-01
End date: 2015-09-30
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

The release of metals into the environment from anthropogenic activities entails major risks to ecosystems and human health. The inhalation of airborne particle matter with diameters of 10 μm or less leads to pulmonary disease and lung damage. Moreover, zinc particles are inferred to play an important role in heterogeneous processing of NOx species. Therefore, sources and fate of metals need to be fully understood so that abatement policies can be developed and emissions are maintained at sustainable levels. The differences in the relative mass-dependent abundances of stable isotopes allow the determination of the sources of metals and thus have the unique potential to tackle this problem. Significant isotopic variability of priority pollutant metals such as Zn, Cu and Cd has been observed in urban environments, suggesting that the metal stable isotopes can be successfully used for source tracing, similar to the very successful approach with Pb. ISOTRACE addresses the potential of the stable isotope technique as a novel technique to trace metal pollutants in particulate matter of the urban environment in a systematic and comprehensive way. This will be achieved by the first experimentally determining of the isotope fractionation of Zn, Cu, Cd and Fe during various industrial processes using well-controlled laboratory tests. Also, new laser ablation techniques will be used to map isotope fractionations in situ in aerosol samples for precise and accurate isotope ratio measurements. This will be followed by a thorough study assessing the isotope variations in sources and sinks of urban atmospheric particulate using a large measuring campaign in London urban environment which will provide potential additional information on transboundary pollution and allow the development of the first model of toxic metal cycling in a megacity.

Keywords: c106 analytical chemistry,c131 environment chemistry,v201 atmospheric chemistry - air pollution,c103 spectroscopic and spectrometric techniques
Metallic engineered nanomaterial in natural aquatic environments: data generation, management and integration into environmental exposure modelling (NANOADJUST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2012-IOF, 2012)
Start date: 2013-12-01
End date: 2016-11-30
Duration (months): 36.0
Total project cost (EUR): 263510.1
EU funding (EUR): 263510.1
Participants: 1
Project status: CLOSED

The success of novel, new technologies often depends to a large degree on the public’s risk-benefit perception. Engineered nanomaterials (ENMs) perceived risk is largely based on uncertainty as to their release and fate in the environment. The “nanoADJUST” project will develop expertise in the application of techniques and tools used to characterise and analyse the behaviour of metallic ENMs in natural aquatic media and integrate this expertise with environmental exposure modelling and risk management data requirements and processes. Data handling throughout the risk assessment (RA) process will be analysed and a statistical framework for the acquisition and management of nano-relevant data at all stages will be developed. Partitioning experiments in natural aquatic matrices shall address current research questions on ENM behaviour and fate, generating data for use in exposure modelling and RA. Fit-for-purpose analytical methodology shall be developed for quantification of nanoparticle related elemental concentrations in model experiments and aquatic environmental matrices. Within this work the concept of isotope tracer studies will be introduced into the emerging area of environmental based ENM research. Behavioural indicators or descriptors (i.e. partitioning likelihood distributions) shall also be developed for use in metallic ENM experimental analysis, exposure monitoring and risk assessment, and identification of organisms at risk of metallic ENM toxicity. The analytical and modelling expertise gained through this research work will complement RA projects related to other biological and chemical risks (pesticides, pathogens, etc.) at the researcher’s European institution. It will also provide support and risk assessment expertise to other nano-related projects undertaken on an institutional and an EU level. The ability to generate, analyse and manage relevant ENM fate and behaviour data will support the high level risk modelling efforts under way within the EU.

Keywords: risk assessment,exposure modelling,metallic engineered nanomaterials,environmental aquatic fate,environmental aquatic behaviour,partitioning coefficients,enriched isotope distribution.
Structural analysis of the interaction of the chromatin associated factor Dot1 with chromatin and mixed-lineage-leukemia fusion proteins (INCAF DOT1)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2012-IEF, 2012)
Duration (months): 24.0
Total project cost (EUR): 184709.4
EU funding (EUR): 184709.4
Participants: 1
Project status: CLOSED

Chromatin structure is influenced by covalent modifications of histones which lead to the recruitment of proteins that recognize specific regions in the genome. Histones undergo a variety of post-translational modifications. These modifications modulate a multitude of DNA based processes such as transcription, repair, replication and chromatin dynamics. Methylation is one of these important modifications. In this proposal the histone methyltransferase Dot1 (disruptor of telomeric silencing) is investigated. Dot1 methylates lysine 79 located in the globular histone-fold of histone H3 and is therefore the first histone modification enzyme discovered that modifies a residue in the core region and not in the N-terminal part. This methylation requires minimally a nucleosome core particle (NCP), consisting of 147bp of DNA and a histone octamer containing a central H3-H4 tetramer and two H2A-H2B dimers. The ability of Dot1 to bind and modify a nucleosomal substrate makes it an ideal model enzyme to study the interaction of the nucleosome with such regulatory factors. In this approach x-ray crystallography combined with disulphide crosslinking will be used to study the Dot1/NCP interaction. Heterochromatic gene silencing, DNA repair, embryonic development and human leukemia are only some of the processes Dot1 is involved in and they also contribute greatly to its interest. As part of leukemia pathogenesis Dot1 was shown to interact with the MLL (mixed lineage leukemia) fusion protein AF10, Dot1 therefore plays a significant role in misregulation of MLL oncogenes. The structural information obtained by x-ray crystallography about the Dot1/AF10 interaction will give insights into leukemia pathogenesis whereas structural studies of the Dot1/chromatin interaction would be a major step to understand the interaction between chromatin and chromatin associated factors and would therefore be a milestone in chromatin biology.

Keywords: chromatin,methyltransferase,x-ray crystallography,dot1,nucleosome,mll-af10,histones,telomeric silencing