Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Soft Bioelectric Implant from Droplet Networks (BIOELECTRIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The goal of BIOELECTRIC is to fabricate and validate robust, durable and biocompatible soft bioelectric implants (SBI) that deliver ionic therapeutics. Fundamental science derived from our ERC Advanced Grant SYNTISU has generated a functional laboratory version of such an implant, but it is extremely fragile. Robustness and durability will be addressed by using advanced hydrogels to build the framework of the SBI and selected block copolymers to improve the performance of the essential membranes within them. These materials will be chosen with a view towards biocompatibility, which will be confirmed by a variety of tests on human cells. The functional properties of the SBIs will be tested on neurons and muscle cells in culture. Variations of the SBI device will be applicable to a wide range of medical conditions: for example, retina replacement, spinal cord regeneration, and wound healing. BIOELECTRIC will also enable us to work with a highly-qualified consultant to conduct market analysis and develop a strong business plan to increase investor confidence, which will in turn allow us to raise significant capital funding for a spin-out company: Soft BioElectric. Accordingly, the scientific program of BIOELECTRIC will culminate in the fabrication of a portable demonstration unit for presentation to potential investors, partner organisations and clinicians. Business planning will be carried out with the support of Oxford University’s technology transfer office (OUI) and a select international panel of advisors. The developing awareness that critical cell, tissue and organ behaviours are regulated by endogenous bioelectricity has opened up the new and vital area of bioelectronic medicine. Together, the scientific and business aspects of BIOELECTRIC will expedite the commercial application of SBIs in this emerging field and deliver significant value to the European economy.

Keywords: applied bioengineering,synthetic biology,chemical biology,nanobiotechnology,biomaterials,biomaterials synthesis,biological chemistry
ZEolite synthesis in Unusual Reactors for Enhanced CAtalysts (Z-EURECA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1498500.0
EU funding (EUR): 1498500.0
Participants: 1
Project status: SIGNED

Approximately 9 out of 10 chemical processes use a solid catalyst, as they increase the efficiency of chemical reactions while being recyclable. Zeolites are one of the most iconic types. These porous crystalline oxides are built from networks of aluminum and silicon nodes and are characterized by regular pores with dimensions similar to most of the molecules that sustain modern society. Although zeolite synthesis is essentially an assembly of silica and alumina around positively charged template molecules, the outcome heavily depends on kinetics. Yet, classic reactors and strategies barely allow any fine-control over the kinetic interplay, and thus the zeolite made, due the complex and not well understood role of Coulomb and other interactions among the assembling species, and their concentration profiles. Even for established catalysts, synthetic control over their key properties is often lacking. However, such fine-control is essential to develop better catalytic processes in the light of global challenges. Z-EURECA wants to revolutionize zeolite synthesis, not by the usual search for ingredients, but by introducing new reactor-based handles, specifically external electric fields and fed-batch modes, to exert control over kinetic pathways. Based on new reactor designs, active manipulation of the various Coulomb and interspecies interactions and local concentration gradients during synthesis will be possible. This bottom-up revolution will i) provide missing insights into the fundamentals of relevant zeolite synthesis, ii) develop active tools that engineer access to synthetic fine-control over zeolites and iii) validate this fine-control in relevant catalytic reactions for superior acid and redox zeolites in prominent sustainable catalysis challenges of our resource-hungry society.

Keywords: zeolite synthesis,reactors for porous material synthesis,bottom up catalyst design,material chemistry,sustainable heterogeneous catalysis
Prosaposin and GPR37 in synucleinopathies (PROGSY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-08-01
End date: 2022-01-31
Duration (months): 78.0
Total project cost (EUR): 1950033.0
EU funding (EUR): 1950033.0
Participants: 1
Project status: CLOSED

The next breakthrough in the treatment of synucleinopathies, incl Parkinson´s disease (PD), will be aimed at interference of disease progression based on insights into the underlying pathogenic process. The pathological hallmark of PD are Lewy bodies (LBs), in which α-synuclein is the major constituent together with other PD-linked gene products (DJ-1, LRRK2, parkin, and GBA) and aggregated GPR37. GPR37 is exceptional among GPCRs having a high propensity for intracellular receptor accumulation and aggregation leading to neurotoxicity. However, unexpectedly, our results suggest that GPR37 is neuroprotective in dopaminergic when located at the plasma membrane. Consistently, prosaposin (PSAP), and its neurotrophic fragment prosaptide, were recently identified as agonists at GPR37. PSAP is a neuroprotective protein that regulates intracellular lysosomal enzyme function, with saposin C being a co-factor of GBA. In addition, we hypothesize that PSAP is secreted following cellular stress and, via membraneous GPR37, cue dopamine neurons to initiate survival pathways. Pivotal to this programme is modeling and analysis of the atomic structures of GPR37 in complex with prosaptide, which will grossly facilitate mechanistic understanding and drug development with potential use in diagnosis and treatment. Novel applications and technological advancements of fluorescence correlation spectroscopy will be implemented for single molecule trafficking of GPR37 and its ligands and will examine whether GPCR multimerization beyond dimer formation may be neurotoxic. Normal and cGPR37KO mice will be virally transduced by α-synuclein to delineate in the relative contributions of improved lysosomal function versus GPR37 agonism for neuroprotection by prosaptides. Evolving from the autopsy studies that anti–GPR37 label LBs and that prosaposin is released upon cellular injury, we will develop GPR37 ligands as PET tracers for LBs in synucleinopathies.

Keywords: gpcr
Application of Virtual Anastylosis Techniques for Architectural Research (AVATAR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

For anastylosis, historical data, temporal analyses and the current study of the element, are fundamental components that serve as a basis for decision making in CH reconstruction, restoration, management and dissemination. The ambitious purpose of AVATAR (Application of Virtual Anastylosis Techniques for Architectural Research) project is to contribute to anastylosis techniques with a new approach based on the latest technological fields. AVATAR intends to develop and optimize a set of procedures and tools to interpret the structural and conservation status in the architectural heritage, supporting decision-making and promoting the change of current practices towards preventive approaches to conservation, under the slogan “It is better to prevent than cure”. Thanks to our knowledge of the history of CH assets, it will be possible to prevent their deterioration in the future. These developments will contribute towards European excellence, enriching the society and helping in the cultural integration of the respected assets.

Keywords: digital twin,geomatics,geophysics,computer vision,machine learning,deep learning,cultural heritage,building information modelling,virtual reality,augmented reality
e-Infrastructure Reflection Group Support Programme 6 (e-IRGSP6)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Coordination and support actions
Countries involved: Germany,Cyprus,Greece,Netherlands,Netherlands
Call: Policy and international cooperation measures for research infrastructures (H2020-INFRASUPP-2018-1, 2018)
Start date: 2019-01-01
End date: 2021-09-30
Duration (months): 33.0
Total project cost (EUR): 599981.25
EU funding (EUR): 599981.25
Participants: 5
Project status: CLOSED

e-IRGSP6 will provide the core services to the e-Infrastructure Reflection Group (e-IRG). The project will support e-IRG in its activities producing high-level policy recommendations towards the implementation of EOSC, EDI and the e-Infrastructure Commons overall. The activities include the operation of the secretariat, i.e. organisation of e-IRG and outreach events and provision of secretarial support to e-IRG, its Chair and Executive Board. The provision of editorial support during the preparation of policy documents, as well as the support to e-IRG working groups and task forces are also vital services needed by e-IRG. The communication and lie-IRGSP6 will provide the core services to the e-Infrastructure Reflection Group (e-IRG). The project will support e-IRG in its activities producing high-level policy recommendations towards the implementation of EOSC, EDI and the e-Infrastructure Commons overall. The activities include the operation of the secretariat, i.e. organisation of e-IRG and outreach events and provision of secretarial support to e-IRG, its Chair and Executive Board. The provision of editorial support during the preparation of policy documents, as well as the support to e-IRG working groups and task forces are also vital services needed by e-IRG. The communication and liaison activities include the dissemination of the outputs of e-IRG, liaison with its various stakeholders, in particular ESFRI, the operation of the external and internal e-IRG web presence and maintenance of the social media outlets. e-IRGSP6 will also assist the EC, the Members States and Associated Countries with communication activities around EOSC and EDI/EuroHPC. Through these supporting activities by e-IRGSP6 and in its capacities e-IRG will contribute to the implementation of EOSC and promote the cultural change towards Open Science principles. The consortium is very experienced and well-connected in the field through long-term involvement in previous e-IRG support projects.

Keywords: e infrastructure,policy support,e irg,e infrastructure reflection group,e infrastructure commons,eosc,esfri,eurohpc
the new gold standard for nondestructive testing in industry, using next generation electromagnetic induction techniques (SECURE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Greece
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Non-destructive testing (NDT) is a critical process in industry, used to ensure safety, quality control and asset management (i.e. accident prevention). NDT techniques range from simple visual inspection and magnetic particle inspection to advanced technologies like ultrasonic testing, radiography, and eddy current testing. Each solution has features that make it more or less suitable for determined sectors and applications. Due to the vast variety of materials and applications in the NDT market, no single NDT method can find all defects in all cases. Applying several technologies to an entire, complex industrial asset is not cost effective. The biggest challenge for the NDT market is to provide high quality inspection in the shortest possible time. High quality inspection in less time allows NDT technicians to have better data and more time to evaluate the results and make critical decisions on the condition of the asset, which reduces the probability of a catastrophic accident occurring. SECURE is a breakthrough solution for non-destructive testing that is able to detect defects in both surface and subsurface inspection, and over coating or insulation, on all conductive materials. SECURE is the first NDT solution that can work in a truly wide range of sectors and applications. Our proprietary method, based on advanced electromagnetic induction technology, offers unprecedented sensitivity for in-depth flaw detection with a quick scan, and is affordable and easy to use. We will initially target the largest areas and applications of NDT, such as welding and corrosion mapping in the oil and gas sectors. With over 7,000 NDT inspection companies worldwide, our total addressable market is worth 600M€. We have received expressions of interest in our technology from market leading NDT stakeholders. With the successful commercialization of SECURE, we project accumulated revenues of over 33 million euros and the direct creation of 155 jobs by year 5 after market launch.

Keywords: non destructive testing,industry,asset management,electromagnetic induction
Continuous two-dimensional Stretch monitoring of fresh tissue Biopsies (StretchBio)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Denmark
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 3822695.0
EU funding (EUR): 3822695.0
Participants: 5
Project status: SIGNED

Mechanical tension and stresses are considered key factors associated to the control of the growth and proliferation of tumoral cells and tissues. Monitoring of such stresses would help to better understand cancer progression and also to test the effectiveness of anticancer drugs aiming to restore normal tissue mechanics. However, there is no current system available for monitoring the cellular mechanical properties, particularly for small tissue biopsies like those obtained with core needles. The overall goal of the StretchBio project is the design, development, fabrication and proof of application of an advanced label-free and compact nanosystem for the continuous monitoring and quantification of mechanical stresses in ex vivo fresh tissue biopsies. This nanodevice will allow testing the changes of these tissues upon their treatment with anticancer drugs for improved drug screening. The basic principle of StretchBio is a two-dimensional force sensor based on an array of nanopillars, constituting a photonic crystal, in which the bending of one or more nanopillars, caused by the mechanical forces exerted by the living tissue, will give rise to a change in the transmitted light through the photonic crystal. The design and fabrication of this compact nanosystem needs to be addressed in concomitance with liquid cell culture media, which will constitute the interpillar medium, and with the fact that the ex vivo fresh biopsy needs to be placed on top of the nanopillars. The proposed approach will be an enormous leap in the study of tissue growth and of drug screening in solid tumours whose progression is markedly contributed by tissue stiffening. This represents an innovative approach to personalized medicine, allowing the development of ad-hoc treatments.

Keywords: photonic crystal,force measurement,nanosystem,silicon,biopsy,solid tumour,drug screening
Multimodal X-ray and Hyperspectral Thin-Film Nano-material Evaluation and Quality Imaging (NanoQI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Germany,Norway,Czechia,Netherlands,Netherlands
Call: Real-time nano-characterisation technologies (RIA) (H2020-NMBP-TO-IND-2019, 2019)
Start date: 2020-03-01
End date: 2023-08-31
Duration (months): 42.0
Total project cost (EUR): 4994792.5
EU funding (EUR): 4994792.5
Participants: 8
Project status: SIGNED

Functional performances of nano-materials and thin films with nano-scale thickness are determined not only by material selection but also by their nano-physical dimensions, nano-scale structure and their nano-scale chemical composition. Precise characterisation of these properties is critical to develop new functional nano-materials and optimise processes toward higher performance, improved reproducibility and yield and up-scaling to larger quantities. X-ray characterisation techniques such as X-ray diffraction analysis (XRD) or X-ray reflectometry (XRR) are widely used in research laboratories for this task but are rarely used in industrial material development and assessment of production processes due to technical limitations and required high level expertise. The project NanoQI targets the development of an industry-suited, real-time and in-line capable technique to characterise nano-structure and nano-dimensions of (thin-film) nano-materials by optimisation of area-detector based XRR and XRD concepts and their multi-modal combination with a novel wide-angle hyper-spectral imaging (HSI) technique. Therewith, NanoQI will provide industry access to real time evaluation of nano-material geometry, structure and morphology and correlative imaging of deviations of these properties. NanoQI technology will be demonstrated in three relevant industrial application scenarios: in-situ process assessment in manufacturing of perovskite solar cells; large-area vacuum roll-to-roll coating of polymer webs and industrial atomic layer deposition of dielectric and gas barrier layers.

Keywords: x ray diffraction analysis,x ray reflectometry,hyperspectral imaging,thin film nano materials,crystallinity,crystal orientation,surface roughness,surface defect imaging
The Impact of Political Parties on Public Claim Making in European Democracies (PPPCM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Scholars in the social movements literature have usually looked at how forms of collective mobilization (e.g. protest) influence policy and what roles political parties play in this. However, the reverse question of how political parties and policies affect mobilization has rarely been addressed. This project therefore tackles the question of how political parties, rhetorically (i.e. through speeches and manifestos) or by engaging in legislative activities (i.e. proposing and enacting legislation), can affect collective mobilization in certain issue areas in European democracies. Building on the agenda-setting literature, which emphasizes issue attention as the main link between protest and political parties, this project attempts to integrate the social movements and political parties literature and, thus, sociological and political perspectives on collective mobilization and political representation, which have for a long time been disconnected. To assess how parties affect collective mobilization, this project focuses on a new conceptualization of mobilization as public claim making, which departs from the protest-centric paradigm in the literature by incorporating a larger action repertoire and initiator actors. Additionally, in its objective of to theorize and investigate the different ways in which political parties affect collective mobilization, the projects aims to inquire both into how these effects vary cross-nationally and over time, and into the individual-level causal mechanisms underpinning these trends. By reversing the usual question in the literature and focusing on collective mobilization as the main dependent variable instead, this project provides us with a better understanding not only on how and why people mobilize and the role that parties play in this process, but also on political issue priorities and how certain issue areas become prioritized and become more salient or contentious than others.

Keywords: political parties,social movements,mobilization,protest,agenda setting,vignette experiments