Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mining, lobbying and efficient environmental policy (MILO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Italy,Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-12-01
End date: 2019-12-28
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 2
Project status: CLOSED

Natural resources including raw materials are important for the European Union since they are a part of the base of the economy and simultaneously a large pollution and waste source. Sustainable development of the mining sector extracting the raw materials calls for an economic analysis of environmental policy, which is the central theme of the MILO-project. The objective of the project is to investigate the optimal environmental policy of the mining sector with a special emphasis on mining specific features and the choice of policy instruments under lobbying. Through its research results obtained using dynamic optimization methods, game theory and an array of dissemination and communication efforts, the project will help to improve the currently applied policies in Europe. In addition to policy advice, the project will result in new insights on the formation of lobby groups and policy instruments by combining two game theoretical approaches, namely, the common agency framework and coalition theory modeling. The researcher, who is trained in the theory of environmental policy instruments and dynamic optimization methods, will conduct the research and training in FEEM’s international and interdisciplinary working environment and will be supervised by an expert in the research field. The project with its trainings improves his research and transferable skills, and extends his international networks through the host’s contacts and through a research visit. By including versatile training-through-research, multiple dissemination and communication methods, public engagement through the MILO-webpage and blog, and networking the project has a strong impact on the researcher’s career, on the future research collaboration as well as on the public interest.

Keywords: exhaustible resources,dynamic analysis,game theory,lobbying
Patient-specific tumour growth model for quantification of mechanical 'markers' in malignant gliomas: Implications for treatment outcomes. (GlimS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2020-05-31
Duration (months): 36.0
Total project cost (EUR): 247840.2
EU funding (EUR): 247840.2
Participants: 2
Project status: CLOSED

Gliomas are the most frequent primary brain tumours in adults (70%) with Glioblastoma multiforme (GBM) being the most frequent and most malignant sub-type (about 50%). Their growth is characterised by infiltration of surrounding healthy tissue, rapid proliferation, and the formation of a necrotic core. GBM growth often creates biomechanical forces that cause compression and displacement of the surrounding brain tissue. This mass-effect is of direct clinical importance; it correlates to functional loss and pressure-induced brain herniation is the leading cause of death for 73% of patients, however this is not used to inform treament. Overall long term prognosis for GBM remains poor, with median overall-survival below 1.5 years and 5-y survival rates below 3%. We hypothesize that biomechanical Glioma “phenotypes” can be distinguished by mathematical models that estimate the forces that produce tissue displacement. Forces building up as a result of tumour growth might alter the behaviour of cancer cells and can reduce blood perfusion by compressing intra-tumoral blood vessels thus affecting drug delivery. We therefore expect that biomechanical factors may have direct implications not only on the biophysical level, but also for clinical decision making, affecting treatment response and outcome. This project seeks to understand the role of biomechanics in the formation of different GBM phenotypes, and to identify “biomechanical markers” that can be used to inform clinical decision making for individual patients. A mathematical model of tumour growth and biomechanical tumour/healthy tissue interaction will be developed and characterised in a multi-step validation procedure. This model will be tested with clinical data and may allow for characterisation of the biomechanical fingerprint of individual patients. Its impact on treatment outcomes will be investigated in in silico studies with clinical data.

Keywords: cancer,brain,glioma,biomechanics,in silico oncology,reaction diffusion model
Structural Visualization of Medieval Manuscripts (StruViMan)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-02-01
End date: 2018-07-31
Duration (months): 18.0
Total project cost (EUR): 149150.0
EU funding (EUR): 149150.0
Participants: 1
Project status: CLOSED

In the 21st-century world of manuscript studies there is a gold rush for digitalization. More and more medieval manuscripts are becoming available in digital format. This opens up entirely new vistas of understanding both for the interested public and for academic research. However, the availability of digitized images is not sufficient in itself, because a medieval manuscript is more than just a series of pictures. In order to understand its diachronic dimension (its development over the centuries) and its cultural meaning (its texts and images), a deeper analysis is required. At the present stage there is a gap between the world of digitized images (with ever more sophisticated viewers) and the rather conventional metadata (where methodology also becomes increasingly sophisticated). Metadata are usually gathered in printed catalogues; today they are sometimes made available online along with the digital image. StruViMan is a software tool that aims at bridging this gap. Existing metadata can be analyzed and visualized digitally. It will be possible to see a manuscript’s macro-structure at a single glance, including its materiality and its historical development. Likewise, it will be possible to reconstruct entire manuscripts virtually, where they are fragmentary today. With the help of this new tool it will be easier to answer questions such as the following: How many texts and miniatures does a manuscript contain and how are they distributed? What is the relationship between texts and paratexts (such as introductions, tables of contents, colophons, possessors’ notes, etc.)? How did the manuscript in its present shape (its library “shelf unit”) grow over time? What did a manuscript look like when it was whole (before being divided up and having its parts taken to different libraries)? How does one manuscript relate another one like it?

Keywords: visualization,medieval manuscripts,early printed books,libraries
Mechanisms of epidermal stratification and force-mediated regulation of stem cell fate and positioning (SkinForce)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Finland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 180692.58
EU funding (EUR): 180692.58
Participants: 2
Project status: CLOSED

As a self-renewing organ maintained by multiple distinct stem cell populations, the epidermis represents an outstanding, clinically relevant research paradigm to address mechanisms of stem cell regulation. To achieve the dynamic turnover and maintenance of the critical skin barrier function, epidermal stem cells (SC) commit to differentiate and delaminate from the basal layer to form suprabasal layers. What triggers SC differentiation, how the differentiating cells move upwards, and how differentiation and self-renewing divisions are balanced remain key open questions. Cells within the epidermis are constantly exposed to tissue- and cell-scale forces that result in changes in cell and nuclear shape and volume. Based on the emerging role of cell density and size in regulating SC fate, I hypothesize that dynamic nuclear and cell shape changes play central roles in regulating epidermal SC fate and in coupling fate changes to cell positioning within the tissue. By combining an innovative, live embryo imaging pipeline, quantitative image analysis, and theoretical models, I aim to decipher the dynamics of epidermal morphogenesis. Using transgenic reporter mice for the nucleus, plasma membrane, cytoskeleton, and differentiation, I will map large-scale and local mechanical transitions along the developmental timeline and correlate them with nuclear and cell shape changes, cell division, differentiation and delamination. I will combine these quantitative imaging experiments with computational modeling, genetic manipulation of contractility, spatial single cell transcriptomics and in vitro cell biology to discover the cellular and molecular mechanism by which tissue geometry and cell/nuclear shape guide cell fate and dynamic positioning. Altogether, this project will uncover fundamental mechanisms of epidermal stratification during development and homeostasis.

Keywords: tissue mechanics,nuclear deformation,epidermal stratification
Mediatized Discourses on Europeanization and Their Representations in Public Perceptions (MEDIATIZED EU)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Research and Innovation actions
Countries involved: Spain,Estonia,Ireland,Hungary,Belgium,Georgia,Portugal
Call: Evolving European media landscapes and Europeanisation (H2020-SC6-TRANSFORMATIONS-2020, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 2869506.25
EU funding (EUR): 2869506.25
Participants: 7
Project status: SIGNED

The media framing of politics significantly shapes the features of political modernity. This discursive mediatization signifies a cultural shift in modern politics and is often driven by political preferences, as well as economic policies that underline media action. In such conditions, news coverage often tends towards a more cynical representation of politics, and the public becomes more alienated from political processes and the media. Scholars term this the “spiral of cynicism,” or, in the context of EU news, a “spiral of Euroscepticism” (Galpin & Trenz, 2016, 2). The latter is reflected in the ongoing shift from “permissive consensus” to “constraining dissensus” (Hooghe and Marks, 2008) in public support of European integration. Media framing of the European project thus plays a crucial role in constructing citizens’ perceptions of the EU and European identity and attitudes towards EU enlargement. The MEDIATIZED EU project aims to study how the media discourses are constructed to foster or hamper the European project and how they resonate among the public by focusing on the elite-media-public triangle. We believe it is crucial to reveal the specifics of such mediatization of political discourses on Europeanization across Europe, namely, the so-called Old and New European and EaP countries. We will take a comprehensive mixed-methods approach with qualitative, quantitative and deliberative research components. We will integrate desk research to review the transformations of media discourses since the start of the 21st century, content analysis and critical discourse analysis of the current media discourses, in-depth interviews with political and media elites, nation-wide representative surveys of the population, and finally, deliberative discussions with relevant publics in the target countries. The project will provide a cross-country comparative analysis of seven target countries, as well as develop policy recommendations for national and EU policymakers.

Keywords: media,europeanization,european union,media systems,discourses
Feasibility Study: A First-of-its-Kind Software-Defined Virtual Reality Camera (AbsZero)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Denmark
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Virtual reality (VR) is a long awaited technology which can be named as #1 media to influence the way how modern society will consume video content in the future. Up to 400 million consumers will become the audience for VR content until 2020. However, there is a grass-root problem with VR content generation as there are no viable solutions for the masses to produce their own videos. Current solutions to create VR videos are underlying some substantial barriers with regard to the current state of technology. To produce such videos is either a) very expensive, or b) requires extensive knowledge and work, and can thus only be done by professionals. Absolute Zero (AZ) is a first-of-its-kind VR camera designed to solve exactly this substantial problem from scratch, by enabling a mass audience of private and business customers to record own VR content in a simple fashion and a highly-defined quality. By developing a novel system architecture, we integrate cloud-based data processing as a natural extension to the actual hardware, which allows us to gain a disruptive competitive advantage with respect to the rest of the VR camera industry. Our technology leads to five key differentiating improvements: 1) Significant reduction of hardware costs of up to 60% 2) Practically unlimited processing power 3) Infinitely scalable storage space 4) Less power consumption 5) Post-sale implementation of new functionalities In Phase 1, we will execute a feasibility study in order to identify remaining economical, legal, and operational barriers, and to develop the right strategy for a further proceeding. A subsequent goal is to address and eradicate these shortcomings within Phase 2, in order to bring the technology to maturity, and to build up a business side for an effective go-to-market.

Keywords: feasibility study,business plan,field test,new business opportunities,virtual reality,cloud processing,internet of things
Improved detection of underground pipes by Multiple Input Multiple Output (MIMO) radar for The Radar Networks (MIMODETECT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: France
Call: Engaging SMEs in security research and development (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In February 2008, an explosion caused by the build-up of gas from an accidental leak killed one of the firemen investigating the scene and injured 26 people. In France alone, 4 500 accidental leaks occur every year through unthoughtful excavation of surrounding construction works, whilst in the UK alone 30 to 40 incidents happen each year where workmen are seriously injured by accidentally slicing through electricity cables. Without even factoring in the estimated time a cost expenses due to service outages, it has become a safety priority to improve underground utility (UU) network detection protocols. Developing better detection technologies, which reduce the reliance on the interpretation of the operator and have the ability to differentiate between types of pipelines in different soil conditions, has become an urgent priority. DetectReseaux aims to exploit the business opportunity brought forward by a national project to map underground utilities by 2020 (€1 billion investment) by developing a novel detection technology and an innovative franchise model to provide 44 direct jobs and €4.5 million in five years. Moreover, improved knowledge of geolocation of underground utilities will help prevent hundreds of injuries every year across the EU. The Radar Networks (TRN) is a non-intrusive, accurate (<40 cm) and compact solution providing detailed information of shape, size and material of pipes in a variety of soil conditions as well as a faster data analysis, allowing to reduce the training of the detection operators by 85%. TRN will position us ready to export our franchise business model to the international scene by 2020, when EU-wide legislation is expected to be introduced.

Keywords: detection,radar,utilities,civil engineering,accident
Glycoprotein-based inhibitors of shiga-like toxin (GlypStx)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-01
End date: 2020-03-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Gastrointestinal infections have substantial impact in both the developing world and in Europe with 1.5 billion cases each year leading to approximately two million deaths each year, 760,000 of which are in children under five years old. Many of these deaths are caused by bacteria for example E. coli O157, that produces protein toxins, including shiga-like toxin (SLT). In the human body, the surfaces of living cells are covered in complex carbohydrate molecules. This “sugar coating” allows the cells to interact with viruses, bacteria, and toxins that have complementary protein receptors. The pentagonal shiga-like toxin produced by E. coli O157 bacteria can attach to five copies of a specific carbohydrate on the gut wall and enter cells lining the intestine. The result is bloody diarrhoea and the toxin entering the circulatory system to cause kidney failure. In this project, we will make protein-based inhibitors that can prevent this toxin from attaching to, and enter kidney cells. The inhibitors will be synthetic glycoproteins that have 5 copies of the target sugar attached at specific sites so that they can bind to all 5 of the toxin’s receptor sites simultaneously providing an extremely strong interaction to prevent the toxin from entering cells. During the project we will synthesise a series of glycopeptides and attach them to pentameric protein scaffolds using site specific chemical and enzymatic modification. We will evaluate the glycoproteins as inhibitors of toxin adhesion and cell entry using a variety of cell and biophysical assays. The optimized inhibitors will have potential as a new class of future biopharmaceuticals.

Keywords: glycoprotein,bacterial toxin,multivalency,protein engineering,glycobiology,carbohydrate,glycopeptide
Celluloepidemiology: a novel paradigm for modeling T-cell responses on a population level. (CELLULO-EPI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1499734.0
EU funding (EUR): 1499734.0
Participants: 1
Project status: SIGNED

As a paediatrician who specialized in immunology and as a physicist who specialized in mathematical modeling of infectious diseases, I want to introduce with this project a paradigm shift in infectious disease epidemiology through the concept of celluloepidemiology. Celluloepidemiology is a term I invented to describe my proposed interdisciplinary approach combining unique cellular immune responses against pathogens on a population level with mathematical modeling, thereby generating unique and otherwise not obtainable multidimensional T-cell profiles. CELLULO-EPI will develop and use such a highly innovative model to simulate how T-cells against pathogens evolve in a synthetic population as a function of age, gender, time since infection and other relevant variables. This model will be parameterized and fitted by cross sectional T-cell data against a wide set of pathogens from 500 individuals (sampled again after 1 year), unique data from individuals with known first infections with dengue and measles and longitudinal data from individuals re-exposed to chickenpox and parvovirus B19. The insights of CELLULO-EPI will be pivotal for public health. One important example: Varicella-zoster virus (VZV) causes chickenpox but also shingles after VZV reactivation. Vaccination can prevent chickenpox, but the predicted increase in shingles incidence has blocked chickenpox vaccination in many EU-countries. Indeed, re-exposure to chickenpox is hypothesized to protect against shingles through boosting of T-cells. Unfortunately, none of the available epidemiological or immunological tools allow for adequate validation of the boosting hypothesis. However, CELLULO-EPI will be able to solve this persisting VZV vaccination dilemma. Furthermore, CELLULO-EPI will also redefine infectious disease epidemiology, for example by allowing us to back-calculate the time since last exposure. I am convinced CELLULO-EPI can revolutionize infectious disease epidemiology and public health.

Keywords: varicella,zoster,mathematical modeling,t cell,individual based modeling,seroepidemiology