Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A New Blueprint for Chemical Synthesis via Metal-Catalyzed C H Bond Functionalization (METCHACT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Materials and Synthesis
Countries involved: United Kingdom
Call:  (ERC-2010-StG_20091028, 2010)
Start date: 2011-01-01
End date: 2016-12-31
Duration (months): 72.0
Total project cost (EUR): 1499983.0
EU funding (EUR): 1499983.0
Participants: 1
Project status: CLOSED

Synthesis is a fundamental area of science that is crucial to advances in medicine and materials - fields that directly impact modern society. The increasing challenges that our society presents has raised the demands on synthesis to provide new molecules that can perturb biological function or provide a new physical property. This fellowship aims to provide solutions to these problems by developing pioneering synthesis blueprints for how chemists can make any molecule in an efficient, rapid and green fashion. In particular, direct benefits of this research will be realized in the treatment of disease. The bond forming processes that underline our ability to make molecules, large or small, depends on the manipulation of pre-functionalized molecules (compounds that need to be prepared through additional synthetic steps). However, the most common type of chemical bond in almost all organic molecules is the C H bond. Usually, all but a few of these C H bonds are considered as inert and only useful in synthesis if they are in the vicinity of a one of these activating functional groups. To a synthetic chemist, permitting the use of any C H bond as a potential functional group would be like giving them a key to a new world Discovery of new chemical reactivity would lead to new reactions; comprised into a new tool kit for synthetic chemists, this would provide the basis for a molecule-building blueprint that would challenge synthetic dogma. Furthermore, using the traditionally inert C H bond as a versatile functional group would save synthesis time, make synthesis greener , and hence more efficient and cost effective. Therefore, to be able to introduce a general blueprint for chemical synthesis based using any C H bond as a versatile functional group would be a truly paradigm shifting advance, and could have enormous impact on many of the scientific challenges that affect modern society.

Keywords: organic synthesis metal catalysis
Tools for the Detection of Novel Glyco-biomarkers (GLYCOBIOM)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: United Kingdom,Germany,Croatia,Ireland,Denmark
Call:  (FP7-HEALTH-2010-two-stage, 2010)
Start date: 2011-01-01
End date: 2015-12-31
Duration (months): 60.0
Total project cost (EUR): 6806915.8
EU funding (EUR): 5199099.0
Participants: 6
Project status: CLOSED

Glycosylation patterns on glycoproteins and glycolipids are involved in the regulation of inter- and intracellular recognition events and alteration of such glycosylation has been observed in many diseases, notably in a variety of cancers. We propose that a systematic, large scale investigation in this area will provide a rich spectrum of novel and structurally diverse carbohydrate-based highly specific biomarkers. The aim of this project will be to address current bottlenecks in analytical techniques by developing an integrated multidisciplinary approach to glycobiomarker screening and analysis based on current state-of-the-art. We will bring together a number of complementary screening techniques developed in the individual partner laboratories, notably high-throughput LC-ms analysis of carbohydrates, lectins and carbohydrate arrays, to develop an overall workflow for the multiplex analysis of glycobiomarkers. Such carbohydrate-targeted methods will be combined with RNA/DNA and analysis (combining high throughput glycomics with genomics). It will be important to test the workflow against serum and tissue samples of healthy volunteer/cancer patients. In addition, we envisage that the project will generate new analytical tools that can be used in routine analysis of glycobiomarkers in the clinic, including diagnostic imaging. Some of the tools developed in this programme (lectins conjugated to nonoparticles) should also be useful for new quantitative imaging biomarkers for monitoring therapeutic effects and safety in cancer. The involvement of three SME partners will ensure that the technology is compatible with commercial applications.

Keywords: glycans,arrays,lectins,hplc,biomarkers,glycomics,cancer
European collaborative project on Targeted therapy in renal cell cancer: genetic and tumor-related biomarkers for response and toxicity (EUROTARGET)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Netherlands,Netherlands,United Kingdom,Germany,Austria,Iceland,Spain,Netherlands,France,Romania,Germany,Germany,Netherlands,Spain
Call:  (FP7-HEALTH-2010-two-stage, 2010)
Start date: 2011-03-01
End date: 2016-08-31
Duration (months): 66.0
Total project cost (EUR): 7818366.67
EU funding (EUR): 5999550.0
Participants: 15
Project status: CLOSED

Each year more than 63,000 new cases of kidney cancer are diagnosed in the European Union. Approx. 50% of all patients have metastasized renal cell cancer (mRCC) at presentation or develop metastases during follow-up. 5-year relative survival of mRCC has been extremely poor: between 5 and 10%. In the past few years, so-called targeted therapies that suppress angiogenesis have changed the clinical practice for patients with mRCC dramatically. Both response and toxicity to these expensive drugs is, however, extremely variable. With an increasing number of compounds becoming available, choice of compounds and sequence is becoming extraordinary challenging. Classical patient and tumor characteristics appear to have poor predictive ability. The aim of this project is to identify germline genetic markers that predict response and toxicity (by the use of high-resolution whole genome SNP arrays in groups of hundreds of patients treated with different agents), identify expression and epigenetic markers in tumors that predict response (by comparing expression and methylome arrays and kinase profiles in frozen tumor tissue from groups of patients who do (N=30) and do not (N=30) respond to different agents), to integrate these data from different platforms by means of bioinformatics and to conduct focused functional studies on the results in order to improve understanding of the critical molecular and resistance pathways involved. A large European consortium that has recruited and will recruit large numbers of patients ensures that the new markers identified in a first discovery phase can be tested in a subsequent replication phase. We have the ambition to define new validated risk stratification criteria to be used in personalized patient management. These criteria allow prediction of individual therapy response and resistance and will enable the monitoring of successful treatment outcome while reducing unnecessary drug use and expense.

Keywords: metastasized renal cell cancer,targeted therapy,genetic profiling,transcriptome,methylome,kinase activity,translational
Co-ordination and Harmonisation of Advanced e-INfrastructures (CHAIN)

Framework: FP7 — Capacities
Programme: Research Infrastructures
Destination: Support to policy development and Programme implementation
Action type: Coordination and support actions
Countries involved: Italy,Spain,Greece,Czechia,Uruguay,Netherlands,China,India,Germany
Call:  (FP7-INFRASTRUCTURES-2010-2, 2010)
Start date: 2010-12-01
End date: 2012-11-30
Duration (months): 24.0
Total project cost (EUR): 1569725.0
EU funding (EUR): 1100000.0
Participants: 9
Project status: CLOSED

Over the past 6 years, the EC has invested to extend the European eInfrastructure technology and European eInfrastructure (and particularly Grid) operational and organisational principles to a number of regions in the world, and reinforcing the close collaboration and exchange of know-how with similar technologies in other areas. A number of different collaboration models have thus been established between Europe and the rest of the world, while the projects implementing these collaborations have had impacts typically focused on their regions. The CHAIN project aims to coordinate and leverage these efforts and their results with a vision of a harmonised and optimised interaction model for eInfrastructure and specifically Grid interfaces between Europe and the rest of the world. The project will elaborate a strategy and define the instruments in order to ensure coordination and interoperation of the European Grid Infrastructures with other external e-Infrastructures. The CHAIN consortium, consisting of leading organisations in all the regions addressed by the project, will ensure global coverage, European leadership, and most efficient leveraging of results with respect to preceding regional initiatives. First, the project will define a coherent operational and organisational model, where a number of EU countries/regions will possibly act, in collaboration with EGI.eu, as bridges/gateways to other Regions/Continents. Further, the project will validate this model by supporting the extension and consolidation of worldwide virtual communities, which increasingly require distributed facilities (large instruments, distributed data and databases, digital repositories, etc.) across the regions for trans-continental research. Finally, the project will act as a worldwide policy-watch and coordination instrument, by exploring and proposing concrete steps for the coordination with other initiatives and studying the evolution of e-Infrastructures.

Keywords: e-infrastructures,grid
Robotics-enabled logistics and assistive services for the transformable factory of the future (TAPAS)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Contribution of the ICT Theme to Public-Private Partnerships for R&D in the European Economic Recovery Plan
Action type: Collaborative project
Countries involved: Germany,Denmark,Germany,Germany,Denmark,Austria
Call:  (FP7-2010-NMP-ICT-FoF, 2010)
Start date: 2010-10-01
End date: 2014-06-30
Duration (months): 45.0
Total project cost (EUR): 5179257.0
EU funding (EUR): 3400000.0
Participants: 7
Project status: CLOSED

Today’s automation and logistics paradigms make it difficult, time consuming, and costly to change the type of the product manufactured and to scale the production up and down in response to market volatility. Consequently, and with the increasing market uncertainties, it becomes more and more difficult to justify new automation lines. To keep production in Europe instead of shifting it to low-wage countries, this project will break new ground in robot-based automation and logistics as the backbone of a transformable factory of the future, enabling an economic production regardless of changes in volumes and product type.TAPAS pioneers the following tasks in real production environments: mobile robots with manipulation arms will make logistic tasks more flexible and more complete by not only transporting, but also collecting the parts needed and delivering them right to the place were needed. Since moving parts around the shop floor does not create value by itself, TAPAS robots go even beyond: they will automate assistive tasks that naturally extend the logistic tasks, such as preparatory and post-processing works, e.g., pre-assembly or machine tending with inherent quality control. Through this additional creation of value and by a faster adaptation to changes with new levels of robustness, availability, and completeness of jobs TAPAS robots promise to yield an earlier return of investment.To reach the objectives, the TAPAS consortium will iteratively test and validate the developments with two pilot installations of increasing complexity and scale. The drivers behind TAPAS are a robot manufacturer and a system integrator, providing both their production environments for intensive testing and validation, and a software technology provider. Teaming up with three excellent research partners they will develop logistic and assistive robotic solutions for transformable automation that are generally applicable and scalable.

Keywords: robotics-enabled production processes,mobile robot assistant,instruction,planning,control
Building Energy Efficiency for Massive market UPtake (BEEMUP)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Energy efficiency and savings
Action type: Collaborative project
Countries involved: Spain,Germany,Spain,Switzerland,France,Portugal,Spain,Netherlands,France,Netherlands,Sweden,Sweden,Netherlands,Netherlands,Germany,Spain
Call:  (FP7-2010-NMP-ENV-ENERGY-ICT-EeB, 2010)
Start date: 2011-01-01
End date: 2014-12-31
Duration (months): 48.0
Total project cost (EUR): 7675483.38
EU funding (EUR): 4858848.35
Participants: 22
Project status: CLOSED

BEEM-UP will demonstrate the economic, social and technical feasibility of retrofitting initiatives, drastically reducing the energy consumption in existing buildings, and lay the ground for massive market uptake. BEEM-UP involves the building owners at 3 sites in France, Sweden and the Netherlands to implement an innovative approach to go beyond a 75% reduction in space heat energy consumption, in addition to reducing the total energy consumption. Ambitious energy reduction will be demonstrated as the economically most attractive alternative for retrofitting. In integrated design the building owners, industry, designers and energy experts collaborate around the building to reach a higher performance and be more adapted to the tenant needs than if just plugging in separate solutions are used. New concepts will be identified that can be replicated in further retrofit projects. An ambitious monitoring programme to demonstrate the reduction in energy consumption will accompany the whole process, including a period of at least two years after the retrofit. This technical monitoring will be complemented with a social monitoring, focusing on the acceptance of the occupant. A whole programme is designated to involve the occupants in the retrofit. ICT systems (smart metering and building control) will encourage and support energy savings. The main challenge is to turn energy reduction in existing buildings into standard option on the market. Going beyond pure demonstration, BEEM-UP will be develop and exploitation plan based on green value, actively disseminate across Europe, and interact with stakeholders, to create a solid demand for energy reductions by building owners, and make BEEM-UP a model for future retrofits. Before 2020, all retrofit projects in Europe will target ambitious energy reductions: not because it is “compulsory and good”, but because it is the most attractive alternative.

Keywords: energy efficiency,retrofit,market uptake,green value,industry,integrated design
New Advanced iNsulatiOn Phase Change Materials (NANOPCM)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Spain,Spain,Germany,Italy,United Kingdom,Spain,Poland,Lithuania
Call:  (FP7-2010-NMP-ENV-ENERGY-ICT-EeB, 2010)
Start date: 2010-06-01
End date: 2013-05-31
Duration (months): 36.0
Total project cost (EUR): 3534336.2
EU funding (EUR): 2399652.0
Participants: 8
Project status: CLOSED

The overall objective of NANOPCM is the development, implementation, production, and demonstration of low cost and improved Phase Change Materials for new high performance insulation components in existing buildings. For this purpose, different technical innovations will be carried out during this project: 1. New low cost stable thermal storage component based on the anchorage at nanoscale of organic PCMs between the polymeric chains of selected polymers. The PCMs will be based on by-products of different industries. 2. New thermal insulation inorganic nanofoam with thermal storage capacity by the impregnation with inorganic or organic phase change materials. The nanoporous material will help to improve the thermal behaviour of the PCM and the innovative use of hydrated salts (inorganic PCM) in construction materials. 3. Improve the thermal behaviour of the materials developed with the introduction of high thermal conductive nanomaterials, CNT or CNF inside their structures. 4. Improved organic phase change microcapsules with the incorporation of high thermal conductive nanomaterials, CNT or CNF in the shell which will provide better thermal transfer to the organic paraffin inside. The objectives of this project will be achieved through 8 WP´s. WP1 is dedicated to project management, WP2-WP3 are related to the experimental development of the new materials and its characterization, WP5 to the study of the Life Cycle, the recycling possibilities and the minimization of the process cost. Finally, in WP4, WP6, WP7 and WP8 will be dealing with the validation, demonstration and dissemination of the results.

Keywords: insulation,energy efficient buildings,nanomaterials,thermal storage
Development of Nanotechnology-based High-performance Opaque & Transparent Insulation Systems for Energy-efficient Buildings (NANOINSULATE)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Israel,Germany,Germany,Türkiye,Germany,Spain,Spain,United Kingdom,Ireland,United Kingdom,Sweden
Call:  (FP7-2010-NMP-ENV-ENERGY-ICT-EeB, 2010)
Start date: 2010-07-01
End date: 2014-06-30
Duration (months): 48.0
Total project cost (EUR): 6077353.8
EU funding (EUR): 4357545.0
Participants: 11
Project status: CLOSED

NANOINSULATE will develop durable, robust, cost-effective opaque and transparent vacuum insulation panels (VIPs) incorporating new nanotechnology-based core materials (nanofoams, aerogels, aerogel composites) and high-barrier films that are up to four times more energy efficient than current solutions. These new systems will provide product lifetimes in excess of 50 years suitable for a variety of new-build and retrofit building applications. Initial building simulations based on the anticipated final properties of the VIPs indicate reductions in heating demand of up to 74% and CO2 emissions of up to 46% for Madrid, Spain and up to 61% and 55% respectively for Stuttgart, Germany for a building renovation which reduces the U-value of the walls and roof from 2.0 W m-2 K-1 to 0.2 W m-2 K-1. This reduction could be achieved with NANOINSULATE products that are only 25 mm thick, giving a cost-effective renovation without the need of changing all the reveals and ledges. Similarly, significant reductions in U-values of transparent VIPs (3 W m-2 K-1 to 0.5 W m-2 K-1) are shown by substituting double glazed units in existing building stock. Six industrial & four research based partners from seven EU countries will come together to engineer novel solutions capable of being mass produced. Target final manufacturing costs for insulation board (production rates above 5 million m2/year) are less than €7 m-2 for a U-value of 0.2 W m-2 K-1. NANOINSULATE will demonstrate its developments at construction sites across Europe. A Lifecycle Assessment, together with a safety and service-life costing analysis, will be undertaken to prove economic viability. NANOINSULATE demonstrates strong relevance to the objectives and expected impacts of both the specific call text of the Public-Private Partnership “Energy-efficient Buildings” topic “New nanotechnology-based high performance insulation systems for energy efficiency” within the 2010 NMP Work Programme and the wider NMP & Energy Thematic Priorities.

Keywords: nanofoams,insulation,aerogels,biocides,vacuum,barrier films,energy efficient
Sustainable Mass Customization - Mass Customization for Sustainability (S-MC-S)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: New production
Action type: Collaborative project
Countries involved: Switzerland,Italy,France,Italy,Mexico,Romania,Spain,Italy,Germany
Call:  (FP7-2010-NMP-ICT-FoF, 2010)
Start date: 2010-05-01
End date: 2013-04-30
Duration (months): 36.0
Total project cost (EUR): 5079101.69
EU funding (EUR): 3464881.0
Participants: 14
Project status: CLOSED

The S-MC-S project aims at supporting European manufacturing to adapt to global competitive pressures by developing methods and innovative enabling technologies towards a customer oriented and eco-efficient manufacturing. To this end, S-MC-S vision is to define and research a new production paradigm, Sustainable Mass-Customization, while also presenting Customization as one of the main driving forces behind the future success of Sustainability. Nowadays, companies still fail to profit from mass-customization because of: I- there is no real networked environment, based on a common strategy and appropriate Supply Chain, meant to empower mass customization along the entire value chain, nor specific methodologies and tools to handle Mass Customization (MC) implementation. Current industrial MC solutions are focused on single companies, thus far behind from the implementation and exploitation of the concept of multi‐site multi‐nation factory (and the related logistic, legislative, organizational aspects); II- the evaluation of Mass Customization implementation must move beyond the mere assessment of economic aspects, steering towards the integration of Environmental and Social consequences into the assessment of the value chain. S-MC-S addresses these issues by promoting 4 RTD Pillars: 1)Design Tools: defining methodologies and tools capable to manage growing complexity of product, production and supply chain configurations imposed by MC implementation in a networked environment. 2)Assessment model: defining the assessment model needed to evaluate the impact of production systems and different supply chain configurations 3)Business Model: defining the framework and strategies for creating economic, social and ecological value through the systematic implementation of S-MC-S paradigm. 4)New specific MC technology: researching pilot MC enabling technology in 3 different sectors, to support manufacturing transition towards sustainable MC (leather; furniture; stone)

Keywords: mass customization,sustainability,supply chain,supply network