Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Delox Air - Continuous air bio-decontamination compatible with human presence (DeloxAir)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Portugal
Call: EIC Accelerator Challenge: Aerosol and surface decontamination for pandemic management (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-07-01
End date: 2026-12-31
Duration (months): 30.0
Total project cost (EUR): 2767272.5
EU funding (EUR): 1893340.0
Participants: 1
Project status: SIGNED

We learned from the pandemic that air quality is essential for people’s health. Current technologies did not effectively manage infectious diseases propagated by aerosol suspensions of pathogens, leading to the need for social distancing and dramatically impacting the economy and people’s mental health. The challenge is not only cleaning the space but keeping people safe and free from microorganisms’ exposure without harming them with harsh chemicals. Delox AIR solution will change the paradigm of bio-decontamination of airborne pathogens in occupied spaces, a disruptive factor in the market. Based on our proprietary dryVHP, Delox AIR can kill microorganisms in the air with 99.99% efficacy, ensuring 100% human safety and consuming up to 20% less energy than current systems. Delox AIR can be readily integrated into any HVAC systems for continuous air purification. Delox AIR is part of the air purification market. We are targeting the commercial applications that capture the largest market (≈70% in 2021), accounting for €15.0 B by 2030. We will first target settings characterised by high occupancy density, presence of vulnerable individuals, and elevated risk of pathogen spread, such as nursing homes and hospitals, office spaces and educational and governmental buildings. Our business model (B2B) is based on indirect sales through distributors already working in the sector that will easily reach HVAC consultants/contractors (customer) designing and delivering a turnkey HVAC system for the end-user. We request EIC funding to complete the development of our system and validate it in three different types of closed environments. Our solution addresses the EIC Challenge of “Aerosol Decontamination for Pandemic Management”, satisfying the unmet need of facilitating social interaction and preventing disease spread.

Keywords: bio decontamination,air purification,antimicrobial resistance,pandemic,epidemic,hydrogen peroxide,infection control,social distancing,microorganisms elimination,environmentally friendly,hva
ReSearch is your Elevation (SuperScienceMe)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Italy
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 300000.0
EU funding (EUR): 300000.0
Participants: 6
Project status: SIGNED

SuperScienceMe - Research is your Elevation aims at redefining the relationship between art, science, and society, with a strong focus on sustainability and inclusion. Inspired by the New European Bauhaus, championing a holistic approach to sustainability and interweaving environmental, social, and cultural dimensions, and by Prof. Nuccio Ordine's illuminating work "The Usefulness of the Useless" this initiative transcends conventional boundaries, advocating for a collaborative ethos where citizens converge with researchers. The strategic objectives of the project are articulated in four main pillars: (1) to enhance citizen involvement in all stages of the R&I process, (2) to promote excellence in research projects across Europe and beyond, (3) to cultivate a deeper understanding of the EU among the general public, and (4) to elevate the interests of next generations in research and scientific careers, by igniting their curiosity and passion, with a specific focus on girls. Central to our approach is an unwavering commitment to open science, an endeavor to democratize knowledge and break down barriers that hinder accessibility. Through a series of immersive experiences, workshops, and interactive exhibitions, we invite participants to explore the multifaceted intersections of art and science, encouraging dialogue and exchange among experts and the public alike. Through this collective effort, we envisage a future where the pursuit of knowledge is cherished not only for its utility but also for the transformative beauty it imparts to our lives. SuperScienceMe will forge a legacy that affirms the indispensable role of the "useless" in sculpting the future of humanity, (1) ensuring it is inclusive in addressing the complex challenges of our time, (2) creating unique learning opportunities for pupils through direct interaction with researchers and (3) reaching out to underprivileged communities who may not have easy access to scientific resources or formal education.

Keywords: eu missions,new eu bauhaus,sustainability,social inclusion,aesthetics,rri,science dissemination,enjoying research,msca fellow,citizen science,schools,teachers,open science,steam,gender
AI-powered clinical software for automated, multi-modal diagnostics and reporting of MRI and CT spine images. (OMNIBoost)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Bulgaria
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 1000500.0
EU funding (EUR): 1000500.0
Participants: 1
Project status: SIGNED

Smart Soft Healthcare (SSH) is a pioneer in AI-driven medical diagnostics, offering Software as Medical Devices (SaMD) that enhance accuracy, speed, and cost-efficiency in healthcare. Our flagship product, CoLumbo, is a testament to our innovation, providing unparalleled analysis of MRI lumbar spine images. However, to shift radiologists’ perception of CoLumbo from a ‘nice-to-have’ to a ‘must-have’, we’re developing CoLumbo OMNI. This advanced version promises expert-level accuracy across multiple imaging modalities and integrates patient symptoms for comprehensive diagnostics, ensuring SSH’s leadership in the AI-based spine diagnostic market. With the EIC support, we aim to overcome the high-risk technological challenges in developing CoLumbo OMNI and unlock private investments. Our projections show that with EIC backing, CoLumbo OMNI could hit the market by 2026, with sales expected to soar from €2M to €137M within five years, achieving breakeven by 2027. The success of CoLumbo OMNI will fuel our continuous innovation, expanding capabilities to X-ray and beyond, and paving the way for augmented reality in spine surgery, reinforcing our commitment to revolutionizing healthcare through AI.

Keywords: ai,software,diagnostic assistance,lumbar spine,mri,ct
Elucidating the role of macroH2A1.2 histone variant as a metabolic sensor in the epigenetic regulation of leukaemia cell fate. (ChroMet)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

The initiation and maintenance of leukaemia are often regulated through the interaction of epigenetic mechanisms and metabolism, but how these affect each other, is not always fully understood. One of the epigenetic mechanisms that alter cell fate is the replacement of replication-coupled histones with non-canonical variants. MacroH2A (mH2A) variants (mH2A1.1, mH2A1.2 and mH2A2) have a large, metabolite-binding macrodomain and differ from each other solely in the structure of their ligand-binding pocket. Of those three, only mH2A1.1 has known ligands, while the binding partner and corresponding biological functions of mH2A1.2, are still unknown. The preliminary data suggest phospholipid molecules as unique ligands of mH2A1.2. At the same time, they show that the MACROH2A1 is required for the maintenance of the stemness of leukaemia stem cells and leukaemia itself. During the ChroMet project, by using cutting-edge techniques in cell and molecular biology, computational biology and biochemistry, I aim i) to confirm the identity of putative ligands of mH2A1.2 and to biophysically characterize the binding interaction, and ii) to test the contribution of the newly identified metabolite-binding capacity of mH2A1.2 on the leukemia cell differentiation and tumorigenicity. The findings of the project will allow me to describe the mH2A1.2 as an entirely novel metabolic sensor on chromatin, which, through the binding of phospholipid ligands, regulates cell metabolism and impacts leukaemia cell fate. The complementary knowledge and expertise of the hosting group (in epigenetics and metabolism), the hosting institute and long-standing collaborators (in leukemia research), and my own (in biochemical analyses of protein-ligand interactions) will ensure the successful realization of the proposed project and contribute to the development of my career as an independent researcher, committed to exploring an interplay between epigenetics, metabolism and cancer.

Keywords: histone variants,phospholipid metabolites,acute myeloid leukemia,leukemia stem cells
Modelling the Biochemistry of Terpene Synthases (ModBioTerp)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Israel,Czechia,Netherlands,Sweden,Spain,United States,France
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 2671488.0
EU funding (EUR): 2671488.0
Participants: 13
Project status: SIGNED

ModBioTerp aims to train 10 exceptional candidates in biochemistry, AI-guided enzyme modeling, laboratory-directed evolution, and synthetic biology. The focus of this project is on the natural product class of terpenoids, which are the largest and most chemically diverse class of natural products and hold immense potential for biotechnological applications. With the latest EU policy on critical technologies from September 2023, which includes biotechnology and specifically mentions synthetic biology, ModBioTerp is well-poised to address these challenges. Terpene synthases (TPSs) are the enzymes responsible for generating the structural diversity found among terpenoid natural products. These elegant enzymes mediate complex carbocation-based cyclization and rearrangement cascades with various electron-rich linear and cyclic substrates. Terpenes are abundant in plants, bacteria, and fungi, and also form the basis of all life through sterols and other very basic metabolites. The biochemistry of terpene synthases is at the core of ModBioTerp with the focus on the challenge of translating a given enzyme model into the understanding of the product profiles of terpene synthases and providing a strong product prediction tool based on the enzyme models developed. The project will explore and exploit the chemical and biological diversity of terpenoids and develop a new fundamental biochemical understanding of these enzymes, ensuring the technological leadership of Europe. With this project, we will unlock the vast potential of terpenoids and lead the way toward sustainable and innovative biotechnological solutions. In ModBioTerp 10 Doctoral candidates (DCs) will spend their research and training time in academic and industrial groups, that are global leaders in the field of terpenoid biochemistry and enzyme modeling. All DCs will also spend time with secondment partners to learn new techniques and be immersed in different scientific environments.

Keywords: terpene synthases enzyme modelling
Model-Based Estimation and Control of Agricultural Infestations Through Abiotic Changes (PestFinder)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

The goal of this project is to contribute to the ongoing “precision agriculture” revolution by developing model-based control strategies for pest control. The project will be carried out with a high interdisciplinary approach between control and system engineers and entomologists. We firstly aim to develop models and methodologies that can guide in an optimal way the agronomical decisions (both in terms of monitoring and of control actions) that impact pest control. To pursue this aim, the first part of the project will be devoted to the development and validation of models able to capture both the spatial diffusion and the temporal evolution of insects in a plantation. These models will be parametrized w.r.t. environmental parameters (temperature and humidity) and control inputs (e.g., pesticides). The focus will be then shift on how to use these models for pest monitoring, and in particular on the interplay between quality of the estimation and data collection, in order to develop optimal data collection policies. In the last part of the project, we will use the developed results to develop model-based optimal pest control policies. Although we aim to obtain a theoretical framework that is more general as possible, two species of high agricultural interest (Drosophila suzukii and Halyomorpha halys) will be considered to validate the various steps of the theory. This research project has a highly innovative approach and has the ambition at large to promote a new philosophy on pest management that goes beyond qualitative analysis and decision making, proposing a quantitative model-based approach to pest management. The research objectives are highly original and focus on aspects of pest management that are highly relevant both from the applied and the research viewpoint. We believe that the research and the tools that will be developed in this research project will have a major impact on both the scientific and the farmers community.

Keywords: physiologically based models,integrated pest management,pest population modelling,optimal control,precision agriculture,alien species
Gender Equality in Museums: Exploring the Transformation of Female Religious Spaces and Objects into Modern Museum Contexts (GEM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 2
Project status: SIGNED

This project examines the historical transformation of female religious spaces and objects into modern museum contexts. In the 18th and 19th centuries, numerous female monasteries in Europe were abolished during secularization, leading to the reinvention of their spaces as museums and the incorporation of sacred objects into exhibitions. As a result, the cultural memory of these spaces as women's convents faded away. The project's aim is to uncover how the historical dispossession of female ownership of monasteries and sacred objects is evident in contemporary museum displays. Drawing inspiration from "decolonize museums" methodologies, it seeks to propose innovative solutions for addressing gender challenges in modern museum collections. To achieve this goal, the project employs a case study approach with a primary focus on the Essen Cathedral Treasury in Germany. This marks the first transdisciplinary examination of the Treasury from a gendered perspective. The research delves deeply into how gender binaries have historically influenced the representation of this collection, their persistence in current exhibitions, and subsequently, the development of strategies to transform these representations, which can be applied to similar collections.

Keywords: secularization,essen cathedral treasury,female monasteries,heritage making,museum formation,cultural appropriation,sacred objects
First automated risk management platform to enable safety, fairness, explainability, and continuous monitoring of generative AI systems (QuantPi)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 3569250.0
EU funding (EUR): 2498475.0
Participants: 1
Project status: SIGNED

We target the global AI market, which has current value of €187.1B (TAM) and a CAGR of 37.3% until 2029. In this TAM, the generative AI market with €12.5B and 27% CAGR constitutes a sub-market addressed by us. AI risk management and governance sector (SAM) has a current market value of €220M and a CAGR of 42.1% until 2029. Industry leaders, e.g., Musk and Wozniak, request a stepping back from training models with an ever-increasing complexity. QuantPi’s platform is the first all-in-one, model-agnostic, plug & play solution for risk management of generative AI. For the first time, we enable companies developing or operating generative AI systems to automatically assess and mitigate major risks across dimensions such as performance, fairness, robustness, explainability, and more. Our solution assesses conformance with +100 standards and regulations, including the EU AI Act, ISO/IEC 23894, and NIST AI RMF and assists companies in their pursuit of responsible and trustworthy AI systems.

Keywords: generative ai,explainable ai,responsible ai,trustworthy ai,safe ai,fair ai,ai bias,ai ethics
Procurement Capability - Embedding and Driving Innovation (PROCEDIN)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Netherlands,Slovakia,Ireland,Bulgaria
Call: Building capabilities in innovation procurement (HORIZON-EIE-2021-CONNECT-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 576151.08
EU funding (EUR): 499195.72
Participants: 5
Project status: CLOSED

PROcurement Capability - Embedding and Driving INnovation (PROCEDIN) Legal reforms, European, national and regional policies, growing expertise, guidance, tools and case studies, and networks of early adopters are all key foundations for the adoption of (public) procurement of innovation (POI) practices, bringing together business and public sectors. If it is to drive deep, systemic change, the rate, scale and scope of POI adoption must increase. This project will accelerate POI in a specific domain covering two critical areas of innovation – circular economy and green mobility – in the context of European cities’ innovation for sustainability and resilience agendas. The consortium will leverage existing resources and its members’ extensive, pan-European professional networks, and initiate new provisions, to enhance and mobilise POI motivation, knowledge and skills. By mapping the complex landscape of growing expertise, experience and learning infrastructure, and relating resources to the varied needs of different stakeholder archetypes (defined by organization type, extent of POI experience etc), key gaps in provision will be identified and addressed. Particular attention is paid to promoting enduring access to, and increased uptake of, POI guidance and learning resources for buyers and vendors, and to building leadership capacity for driving and embedding innovation through strategic procurement.

Keywords: public procurement of innovation,pre commercial procurement,entrepreneurship
Prematurity and eating behaviour beyond infancy: perspectives and support needs from parents, children, and healthcare professionals (PremEat)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Switzerland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2028-09-30
Duration (months): 36.0
Total project cost (EUR): 442243.2
EU funding (EUR): 442243.2
Participants: 2
Project status: SIGNED

One in 10 babies worldwide are born preterm (<37 weeks of pregnancy). Preterm infants’ nutrition and feeding are well studied during postnatal hospitalisation and early infancy, but little research is available on this topic beyond infancy. Eating and feeding behaviour is currently not part of the follow-up care of preterm children, which may be problematic if eating and feeding difficulties are indeed more common among preterm born children compared to those born at term, as some studies suggest. The main aim of the PremEat project is to provide insight into different stakeholders’ experiences of eating behaviours of children born preterm beyond infancy. PremEat’s specific objectives are: (O1) to explore parents’, children’s and healthcare professionals (HCPs)’ experiences and support needs regarding preterm children’s eating behaviour, (O2) to compare the eating behaviours of preterm children aged 2 to 6 years, the feeding practices of their parents, and influencing factors, to those of a term-born population, and (O3) to develop recommendations and communication material on this matter for families and HCPs. The project will use qualitative (interviews, focus groups) and quantitative research methods (surveys) to gather data in Switzerland (2-year outgoing phase at UZH) and Ireland (1-year return phase at UCD). The project is interdisciplinary in nature, drawing on expertise from the involved partners in psychology, human nutrition, health promotion, neonatology, and developmental paediatrics. The PremEat project is also co-creatively designed with local organisations representing the interests of preterm born children – the Irish Neonatal Health Alliance and Frühchen Schweiz – ensuring that this research is based on their needs and the findings and outputs meaningful for affected families. The project objectives support the Horizon Europe strategic plan (2021-2024) for research and innovation and the EU Global Health Strategy to deliver better health for all.

Keywords: prematurity,eating behaviour,parental feeding practices,pre schoolers,support needs,public and patient involvement,co creation