Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
CamPAign Finance, InfoRmaTIon and InfluenCe: A ComprehensIve APproAch Using Individual-Level Data and CompuTEr Science Tools (PARTICIPATE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1404215.0
EU funding (EUR): 1404215.0
Participants: 1
Project status: SIGNED

The goal of PARTICIPATE is to develop a comprehensive approach to the study of campaign finance, information and influence, using new individual-level data and investigating recent changes in participation behaviors. What are the motives behind small campaign contributions? Does tax policy affect political giving? Why are so few politicians from the working class and can this change? What is the ability of the media to induce citizens to make electoral decisions they would not make if reporting were unbiased? While there is evidence at the macro level on the flow of money in elections, news consumption, or the extent of charitable giving, relatively little is known at the micro level, e.g. on individual-level behaviours such as the motivations of small donors, the tax-price elasticity of political donations, or the exposure to competing information flows. PARTICIPATE will help fill this gap. By providing groundbreaking evidence on new forms of participation, it will lead to the reassessment of influential theories of special interest groups and policy formation. One distinguishing feature of the proposal is to combine comprehensive individual-level datasets and the use of computer sciences tools (such as natural language processing techniques and machine learning). PARTICIPATE will advance the existing research in three steps. First, I will propose a unified analysis of political contributions. This will include a groundbreaking assessment of the importance of small campaign donations, and a combined study of charitable giving and political contributions investigating the impact of tax policy on donations. Fundraising success can lead to the emergence of new candidates. I will then consider citizens’ decision to run for elections, and investigate the role played by network in political selection. Finally, given the importance of media organizations in shaping participation, I will study the changing patterns of information propagation and political influence.

Keywords: campaign finance,campaign donations,charitable giving,tax price elasticity,news consumption,information propagation,twitter,media power,political participation,big data,natural language processing,machine learning,dynamic multidimensional graphs
Insect-borne prokaryote-associated diseases in tropical and subtropical perennial crops (TROPICSAFE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Spain,South Africa,Spain,Italy,Italy,Italy,Cuba,Jamaica,Slovenia,France,France,Mexico,Denmark,United Kingdom,Chile,Ghana
Call: Challenges for disease management: Perennial crops in the tropics and sub-tropics (H2020-SFS-2016-2, 2016)
Start date: 2017-05-01
End date: 2022-04-30
Duration (months): 60.0
Total project cost (EUR): 3999963.75
EU funding (EUR): 3999963.75
Participants: 22
Project status: CLOSED

The project aims to address economically important insect-borne prokaryote-associated diseases of perennial crops (palm, citrus and grapevine) grown in tropical and subtropical areas which are seriously affecting the trade and import of agricultural products and materials worldwide. These diseases are due to the presence of ‘Candidatus Phytoplasma’ associated with “lethal yellowing” in palms and “yellows” in grapevine, and ‘Ca. Liberibacter’ associated with “Huanglongbing” in citrus. These diseases could also present a possible threat to EU agriculture as a result of accelerated climate change that the EU is facing nowadays. The management of these diseases will be focused on tropical and subtropical areas in Africa (Ghana, South Africa and Reunion), the Americas (Mexico, Chile) and the Caribbean (Guadalupe, Jamaica, Cuba), and subtropical regions in Europe (Spain). Prevalence of the aforementioned diseases is severe in these areas, giving rise to social and economic threats, affecting local agriculture and export of products internationally and, in particular, to the EU. Knowledge and technologies available in the EU countries will be deployed in tropical and subtropical regions for carrying out epidemiologic studies aimed at filling gaps in our knowledge (including climatic and cultural factors); integrated pest management strategies based on innovative diagnostic and prevention tools; reduced insecticide treatments; use of defence elicitors and improved resistant germplasm; and pest risk assessment schemes. The project will evaluate the economical sustainability and the industrial relevance of the proposed solutions, and will assess the social impact of these diseases, and the distributive effects in the target countries. Local plant protection organizations, farmers and producers will actively participate as partners and/or in the Stakeholder Advisory Board, taking part in field trials, demonstration and exploitation of the results.

Keywords: palm,citrus,grapevine,phytoplasma,liberibacter,integrated pest management,prevention,technological advances,sustanaibility,lamp,resistance,africa,carribbean,south america
Single cell analysis of the lung tumour-immune ecosystem: Developing new tools for effective immunotherapy (SCALTIE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Israel
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-05-31
Duration (months): 24.0
Total project cost (EUR): 170509.2
EU funding (EUR): 170509.2
Participants: 1
Project status: CLOSED

Tumours evolve to evade immune surveillance through a series of immune suppression mechanisms. In line with this, cancer immunotherapies, in which the immune system is turned on against tumours, are currently revolutionizing cancer treatment. Unfortunately, still many cancer patients do not respond to immunotherapies. Therefore, there is an urgent need to develop new tools for effective immunotherapy in order to increase treatment response rate. However, current methods that investigate bulk populations of cells lack the resolution to identify and analyse the diverse subpopulations of cells and the unique pathways and checkpoints they activate within the tumour ecosystem. I therefore aim to use advanced single cell genomic techniques for unbiased and high-resolution characterization of the different malignant, stromal and immune cell populations within the microenvironment of lung tumour, which is the biggest cancer killer in Europe. In combination with modelling approaches and advanced functional assays, I will identify subpopulations of cells specific to tumours, known and novel pathways mutated in tumour cells and cell-cell interactions that all together play crucial roles in the tumours pathogenicity. A comprehensive understanding of these processes provides the basis for understanding why existing cancer immunotherapies do not always succeed and provides new potential targets for the development of precise medicine tailored to individual patient. Complementary to my skills in molecular and cellular biology, I will acquire scientific skills in single cell genomics and bioinformatics, and soft skills in project management, mentoring, communicating, etc in this project. Those skills will enable me to establish my own research group in the near future to investigate the interface between the immune system and tissues under health and diseases with holistic approaches, which is my long-term career goal.

Keywords: single cell rna seq,cancer immunotherapy,cancer immunology
Host directed medicine in invasive fungal infection (HDM-FUN)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Germany,Italy,Belgium,Romania,Switzerland,Greece,France,Netherlands,United States,Netherlands,United Kingdom,Portugal
Call: Stratified host-directed approaches to improve prevention, treatment and/or cure of infectious diseases (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 10158439.05
EU funding (EUR): 9998170.0
Participants: 18
Project status: SIGNED

Despite novel treatment options and development of diagnostic tools invasive fungal infections (IFI) are still associated with an unacceptably high mortality and morbidity. Experts believe that a host directed approach is needed to overcome this problem. HDM-FUN proposes a transdisciplinary approach to identify host-pathogen factors (HPFs) needed for host directed medical interventions in IFI and will be the first of its kind. The overall concept is to identify host-pathogen factors in the setting of immunotherapy and prophylaxis that will allow the design for tailored novel therapeutic and preventive host-directed medicine approaches for patients with lethal invasive fungal infection in the intensive care. Specific objectives: 1. To identify host-pathogen factors that correlate with disease, and correlate them with preventive or immunotherapy- based strategies to stratify patients for personalized host-directed treatment options. 2. Two clinical trials of host-directed medicine approaches; an immunotherapy trial in patients with candidemia and a prospective observational trial for prophylaxis in patients with influenza at risk for aspergillosis. 3. To set-up a centrally managed biobank with samples of the patients enrolled in both clinical trials, and to standardize experimental procedures, protocols and centralize analysis. 4. To establish a unique infrastructure aimed to: explore host-directed medicine approaches in IFI, evaluate their impact on patients and health care, translate research efforts to clinical practice by designing point of care tests and teaching medical professionals. HDM-FUN brings together top scientists and clinical researchers to unravel host factors (genetics and transcription), immune modulators (metabolome, microbiome), and host pathogen interactions (genetics, metabolomics, immunology, signalling pathways, phagosome biogenesis, and inflammasome regulation) that determine the susceptibility and outcome of patients with fungal infection.

Keywords: fungal immunology,candidiasis,aspergillosis,host directed therapy,cytokine
Novel building Integration Designs for increased Efficiencies in Advanced Climatically Tunable Renewable Energy Systems (IDEAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Italy,Italy,Ireland,Ireland,Spain,Serbia,United Kingdom,United Kingdom,Portugal,Portugal,United Kingdom
Call: Renewable energy system integrated at the building scale (H2020-LC-SC3-2018-RES-TwoStages, 2018)
Start date: 2019-05-01
End date: 2023-04-30
Duration (months): 48.0
Total project cost (EUR): 3999083.75
EU funding (EUR): 3999083.25
Participants: 15
Project status: SIGNED

Buildings play a significant role in the global energy balance. Typically, they account for 20-30% of the total primary energy requirement of industrialized countries, 40% in EU. Applying the proposed integrated RES to buildings is an important application for wider integration and deployment of renewable energy and to achieving our binding EU targets of at least a 40% reduction in greenhouse gas emissions (GHG) by 2030, compared to 1990 and at least 27% of renewable energy in EU. The IDEAS project will create an innovative building integrated renewable energy system (RES) which will cost effectively exceed current RES efficiencies, generating electricity, heat and cooling and optimised for multifamily, public and commercial buildings in different climatic conditions. The research aim is to create a novel low-cost building integrated RES maximizing the output tuneable for different climatic conditions through novel luminescent and geometric concentrator techniques leading to current solar system efficiencies being exceeded electrically. Thermally enhancement will be achieved using enhanced organic phase change materials (PCM) with a passive biomimetic heat transfer mechanism for heat storage and discharge. An electrically driven multi-source heat pumpHP system will then use the main energy sources at building scale (waste heat from the system, air and ground), to provide the input to an integrated underfloor heating and hot water system, and to manage the thermal energy storage. This building integrated RES will use advanced control techniques to maximize performance and electrical and thermal/cooling self-sufficiency in the building. The technology will be optimized and demonstrated for use in multi-family residential buildings, commercial and public buildings.

Keywords: solar,luminescent,phase change materials,heat pumps,demand side management,user engagement
In Silico Trial for Tuberculosis Vaccine Development (STriTuVaD)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Italy,Italy,India,Spain,Netherlands,United States,United Kingdom
Call: In-silico trials for developing and assessing biomedical products (H2020-SC1-2017-CNECT-2, 2017)
Start date: 2018-02-01
End date: 2023-01-31
Duration (months): 60.0
Total project cost (EUR): 5050656.25
EU funding (EUR): 4549527.5
Participants: 8
Project status: SIGNED

Tuberculosis (TB) one of the world’s deadliest diseases: one third of the world’s population, mostly in developing countries, is infected with TB. But TB is becoming again very dangerous also for developed countries, due to the increased mobility of the world population, and the appearance of several new bacterial strains that are multi-drug resistant (MDR). There is now a growing awareness that TB can be effectively fought only working globally, starting from countries like India, where the infection is endemic. Once a person present the active disease, the most critical issue is the current duration of the therapy, because of the high costs it involved, the increased chances of non-compliance (which increase the probability of developing an MDR strain), and the time the patient is still infectious to others. One exciting possibility to shorten the duration of the therapy are new host-reaction therapies (HRT) as a coadjuvant of the antibiotic therapy. The endpoints in the clinical trials for HRTs are time to inactivation, and incidence of recurrence. While for the first it is in some cases possible to have a statistically powered evidence for efficacy in a phase II clinical trial, recurrence almost always require a phase III clinical trial with thousands of patients involved, and huge costs. In the STriTuVaD project we will extend our Universal Immune System Simulator to include all relevant determinants of such clinical trial, establish its predictive accuracy against the individual patients recruited in the trial, use it to generate virtual patients and predict their response to the HRT being tested, and combine them to the observations made on physical patients using a new in silico-augmented clinical trial approach that uses a Bayesian adaptive design. This approach, where found effective could drastically reduce the cost of innovation in this critical sector of public healthcare.

Keywords: in silico clinical trial,agent based modeling,tuberculosis vaccine,bayesian statitstical modeling
Catalytic Reforming of Glycerol to Hydrogen and Biopropane in Hydrothermal Media (HYDROGAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-12-01
End date: 2023-02-28
Duration (months): 15.0
Total project cost (EUR): 133083.6
EU funding (EUR): 133083.6
Participants: 1
Project status: CLOSED

The ultimate goal of this 15 months Fellowship, entitled “Catalytic Reforming of Glycerol to Hydrogen and Biopropane in Hydrothermal Media” (HYDROGAS) is to train a talented researcher through a research project focused on the development of novel process to make viable the use of the glycerol co-product derived during the use of vegetable oils for the production of liquid hydrocarbon biofuels.. This innovative HYDROGAS project aims to investigate for the first time the potential of a novel two-stage catalytic process to produce hydrogen and biopropane from catalytic reforming of glycerol in hydrothermal media. The two-stage approach would enable deriving all the hydrogen requirements for the HEFA by using glycerol as a hydrogen-source. This can contribute to a positive process economics for the HEFA bio-jet fuel production. The transfer of knowledge between the researcher, the host, the supervisor, the students and international research groups will be very important for the dissemination of the learning through training, publications in journals of high impact factor, development of patent and participation in international conferences. The Fellow will receive access to an innovative project experience at the host: Sustainable Chemicals Laboratory in the European Bioenergy Research Institute, Aston University, UK (Dr. Jude Onwudili), and at academic secondment partner: University of Zaragoza, Spain (Prof Lucia Garcia). HYDROGAS aims to investigate the development of a new methodology to produce biopropane for a large-scale deployment in substitution for petroleum-based LPG that can contribute to lowering carbon emissions. In addition, the thermodynamic study to consolidate the catalytic reforming from crude glycerol will be a positive challenge for this team to work together and evaluate the expected results. The HYDROGAS will permeate the whole fellowship and will be a valuable and challenging mixture of scientific research and training for the Fellow.

Keywords: renewable energy,biopropane,hydrogen,catalytic hydrothermal reforming,glycerol
Learning to bracket broadly (BROAD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

As a consequence of reforms of the social security systems in the EU, consumers increasingly face numerous investment decisions that involve risk, such as how to allocate their retirement savings between risky and safe assets. However, consumers often fail to make optimal choices. A key aspect in this context is whether and how people integrate (or “bracket”) the many different choices under risk they face. Evidence suggests that people often bracket narrowly, i.e., they view each choice in isolation and not in the context of the other choices they face, thereby often making choices that are not in their best interest. Understanding what determines how people bracket their choices is therefore of crucial importance. An important open question is whether people can (be induced to) “learn” to bracket broadly through a clever design (or “framing”) of the decision environment. I will investigate this question in a laboratory experiment to establish the scope and limits of learning to bracket broadly. Making the insights transferable across contexts and institutional features requires knowledge about the cognitive mechanisms of this learning. I use recent advances in neuroeconomics to gain a better understanding of these mechanisms using functional magnetic resonance imaging. The project will build on my initial experience in research on choice bracketing and complement this with the existing strengths in behavioral economics and neuroeconomics, as well as, the excellent research and training infrastructure at Maastricht University. The insights gained will lead to a better understanding of how individuals deal with multiple decisions involving risk and “the way consumers understand and choose financial services” (European Consumer Agenda). The project will contribute to the design of policy interventions that help consumers make better decisions via a grant proposal with an industry partner and comprehensive dissemination and communication activities.

Keywords: choice bracketing,myopic loss aversion,risk,investment,framing,behavioural finance,neuroeconomics