Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Re-meshing of a given triangle mesh surface to a quad mesh using physically motivated methods based on the Ginzburg--Landau potential and solved efficiently solved via numerical splitting scheme (GLnQuadRemeshing)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Israel,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2021-09-30
Duration (months): 36.0
Total project cost (EUR): 263385.0
EU funding (EUR): 263385.0
Participants: 2
Project status: CLOSED

Geometric curved objects are ubiquitous in numerous computational science and engineering problems. Representing curved domains in a computer is typically achieved using triangle mesh surfaces. However, it is often beneficial to use quad meshes instead. Namely, discrete surfaces that are composed of quad faces, connected via edges and vertices. Unfortunately, existing re-meshing methods of triangle surfaces are somewhat limited and non-robust, motivating the following research. In this action we describe a new class of algorithms for quad re-meshing of curved domains using PDE-based approaches. Our algorithms use the Ginzburg--Landau (GL) functional and its multiclass extensions to devise novel energy functionals which, unlike previous work, are fundamentally supported by the extensive literature in physics and image processing on the theory, analysis and processing of GL. In practice, convex-splitting or heat and thresholding numerical schemes allow us to quickly find minimizers of the proposed energies. Our approach is novel in that it extends a recent body of work on multiclass classification of high-dimensional data to the problem of quad re-meshing which is typically formulated as a mixed-integer problem, and thus it exhibits heuristic solvers. A common methodology for quad re-meshing includes the design of a generalized vector field (i.e., a cross field) and mesh parametrization. Our research objectives cover both of these tasks and suggest novel methods to tackle them. Overall, the proposed research offers a new point of view for this long-standing problems, and with the vast related work in other domains, it may bridge the gap to arrive at effective, scalable and efficient quad re-meshing machinery of general geometries. The resulting algorithms may be used in several scientific and engineering domains such as architectural geometry, fabrication of curved objects and computer aided design systems, among other applications.

Keywords: ginzburg landau theory,multiclass classification,cross field design,aligned parametrization,curved domains
Digital Healthcare ECOosystem research and innovation capability building (DiHECO)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Spain,Finland,Sweden,Lithuania,France
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2020-12-01
End date: 2023-11-30
Duration (months): 36.0
Total project cost (EUR): 899907.5
EU funding (EUR): 899907.5
Participants: 6
Project status: SIGNED

Digital healthcare services’ multi-sided platform (MSP) is a digital ecosystem for organizing collaboration and control based on software, hardware, and services, without taking ownership of the services whose exchanges it facilitates through diverse inter-organizational interactions. In this way an MSP creates an effect of shared economy and thus greater accessibility, affordability, security and quality of life. Most famous examples of the multi-sided platforms are services such as Uber, Facebook and AirBnB. Although MSP is a game-changer in different business sectors, it is still very rarely applied in healthcare: only some partially similar solutions have been created in France (Doctolib https://www.doctolib.fr/) and in Germany (Otto Bock Health https://www.ottobock.at/). Thus there is an urgent need to advance research and innovations on the application of multi-sided platform (MSP) in digital health care, in order to utilize digital technologies for the sake of value-based, learning Healthcare sector. The overall objective of the DiHECO project is to build the capacities for Kaunas University of Technology (KTU) to conduct high-quality research in the field of digital healthcare management and in particular digital healthcare services’ multi-sided platforms. DiHECO meets KTU’s needs through five specific objectives: Objective 1. Implement experience-based learning through carrying out high-quality small-scale research and innovation initiatives in the field of multi-sided platforms of digital healthcare services; Objective 2. Apply for grants to fund respective digital healthcare management research and collaborative projects involving KTU; Objective 3. Develop the capacities for research and innovation management and administration at KTU; Objective 4. Transfer KTU’s research outputs to digital healthcare ecosystem stakeholders; Objective 5. Build capacities for offering better career prospects to early-stage researchers and step up in gender equality.

Keywords: digital healthcare,multi sided platform,service innovation,digital business model,inter organisational collaboration
SoIL Vibration and AuRalisation Software Tools for Application in Railways (SILVARSTAR)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Germany,Switzerland,Belgium,Belgium,France,United Kingdom
Call: Noise and Vibration (WA5) (H2020-S2RJU-OC-2020, 2020)
Start date: 2020-11-01
End date: 2023-02-28
Duration (months): 28.0
Total project cost (EUR): 950000.0
EU funding (EUR): 949999.5
Participants: 6
Project status: SIGNED

SILVARSTAR brings together a unique consortium of six leading industrial and academic partners who contribute excellence in noise and vibration modelling (ISVR, KU Leuven), engineering consulting (Vibratec, Wölfel), software development for environmental impact studies (Wölfel) and for auralisation and visualisation (EMPA), as well as dissemination of collaborative project results to the European rail manufacturing industry (UNIFE). The overall goal of SILVARSTAR is to provide the railway community with proven software tools and methodologies to assess the noise and vibration environmental impact of railway traffic on a system level. The first overall objective of SILVARSTAR is to provide the railway community with a commonly accepted, practical and validated methodology and a user-friendly prediction tool for ground vibration impact studies. This tool will be used for environmental impact assessment of new or upgraded railways on a system level. It will provide access to ground vibration predictions to a wider range of suitably qualified engineers and will facilitate project planning and implementation by improved simulation processes. The second overall objective of SILVARSTAR is to develop a fully functional system for auralisation and visualisation based on physically correct synthesised (exterior and interior) railway noise, providing interfaces with Virtual Reality visualisation software. This system will facilitate communication with the public, decision makers and designers through virtual experience before delivery of projects.

Keywords: noise ground vibration auralisation visualisation
Understanding the pan-immune system of bacteria (DefenseAgainstPhage)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Israel
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The perpetual arms race between bacteria and phage resulted in the evolution of efficient phage-resistance systems. Such systems, including restriction enzymes and CRISPR-Cas, have a major influence on the evolution of both bacteria and phage, and have also proven invaluable as molecular tools. We recently showed that the bacterial immune system is much richer than originally thought. We discovered the CBASS system (Cohen, Nature 2019), prokaryotic viperins (Bernheim, Nature 2020), and additional defense systems widespread in microbes (Doron, Science 2018). These discoveries relied on the observation that defense systems are organized in defense islands - areas in bacterial genomes where multiple defense systems are clustered together. Mining defense islands resulted in the discovery of new defense systems, but our preliminary results suggest that this is just the tip of the iceberg, and that dozens of new defense systems remained undiscovered in microbial defense islands. In this project we will use new genomic approaches, together with analyses of massive genomic and metagenomic datasets, to systematically map the molecular capabilities encoded within the anti-phage “defensome”. The project combines computational genomics, synthetic biology, and deep genetic and biochemical experiments to discover, validate, and study the properties of new defense systems, as well as mechanisms used by phages to mitigate defense. Specific focus will be given to retrons, microbial elements that produce chimeric molecules where RNA and DNA are covalently attached. We discovered that retrons function in anti-phage defense, and plan to decipher the mechanism by which the RNA/DNA hybrid provides defense. Based on the enormous impact that antiviral systems had on modern molecular biology (e.g. RNAi, CRISPR-Cas), we envision that deciphering the mechanism of new systems could yield not only major discoveries on phage-bacteria interactions, but also new and exciting molecular tools.

Keywords: phage,bacteriophage,anti phage,defense systems,crispr cas,anti crispr,defense islands,abortive infection
Therapy for regeneration of Heart Muscle based on targeted delivery of exosomes (TRoMBONE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 160635.6
EU funding (EUR): 160635.6
Participants: 1
Project status: CLOSED

Given the poor regenerative potential of the adult heart after heart failure (HF), therapies capable of contributing for cardioprotection and cardio-regeneration are of great need. Recent advances in pharmacologic therapy and stem cells are currently not enough to address HF. The hypothesis of this project is that exosomes, nanovesicles secreted by cells may be a potential therapy for HF. Exosomes may offer advantages relatively to cell-based therapies regarding efficacy (does not require engraftment and survival), processing and cost. The main objective of the current project is to develop an effective strategy to deliver exosomes by intravenous (IV) injection into the heart (targeting) and to maximize exosome regenerative potential (bioactivity). Therefore, the project aims to develop a non-cellular-based therapy to regenerate the heart after infarction based on the targeted delivery of exosomes. Undertaking this research along with formal training and mentoring will enhance my academic profile, scientific experience, and content expertise in nanobiotechnology, to enable me to develop into an independent, leading researcher. The proposed research contributes to the EU priority of addressing the societal challenge of improving lifelong health and wellbeing of all.

Keywords: regenerative medicine,myocardial infarction,regeneration of heart muscle,targeted exosomes
Reconciling Europe with its Citizens through Democracy and Rule of Law (RECONNECT)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Italy,Israel,Spain,Norway,Finland,Finland,Hungary,Poland,Belgium,France,Czechia,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Democratic discourses and the rule of law (H2020-SC6-CULT-COOP-2017-two-stage, 2017)
Start date: 2018-05-01
End date: 2022-04-30
Duration (months): 48.0
Total project cost (EUR): 4999686.25
EU funding (EUR): 4999686.25
Participants: 18
Project status: CLOSED

RECONNECT starts from the observation that the European Union (EU) and the Member States are confronted with an existential crisis of the entire European project. As a result of several successive crises an increasingly large share of the population perceives the EU as an undemocratic and unjust political system. Overall trust in institutions at both Union and Member State levels is waning, while ever louder calls for a repatriation of powers to the national level are shaking the EU to its core. Against this background, our underlying assumption is that the deeply diverse and pluralistic Union of today needs to be more firmly rooted in justice and solidarity in order to be sustainable. Our working hypothesis is that European governance can regain authority and legitimacy through democracy and the rule of law, provided citizens’ aspirations and preferences are duly taken into account. This will allow for a renewed trust and recognition of the EU as a policy-provider that acts with a view to genuinely establishing a “society in which … justice [and] solidarity … prevail”, as Art. 2 TEU requires. With a unique multidisciplinary consortium of researchers, we analyse the existential challenges to the EU’s authority and legitimacy, through a comprehensive examination of principles, practices, and perceptions of democracy and the rule of law in the EU. Our end-user approach enables us to point to how democratic and rule of law principles and practices of institutions resonate with the actual aspirations, perceptions and preferences of citizens. Our ultimate objective is to contribute to a new comprehensive narrative for Europe that “reconnects” European governance with citizens. By means of an effective impact and dissemination strategy and through tailor-made policy recommendations and proposals for Treaty changes, RECONNECT will strengthen the EU’s normative foundations.

Keywords: rule of law,democracy,justice,solidarity,legitimacy,sovereignty,loci of authority,citizens,perceptions
International Organisations and the Rise of a Global Metrological Field (METRO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2022-10-31
Duration (months): 67.0
Total project cost (EUR): 1199805.0
EU funding (EUR): 1199805.0
Participants: 1
Project status: SIGNED

The production of global metrics by International Organisations has not only penetrated the transnational social and policy fields; it has also become an integral mode of the ways International Organisations interconnect. Through their collaborative practices of quantification and commensuration, International Organisations are both constituting new realities and being reconstituted themselves. Thus, the dominance of global measurement regimes has profound implications for the ways International Organisations interact, and for the environments these new interrelationships come to generate. How is one to make sense of this emerging reality? The embryonic –but rapidly deepening– alliances between International Organisations to find global solutions to global crises, is an opportune moment for a two-fold enquiry: a. an in-depth investigation of the labour of the joint production of metrics; and b. an examination of the ways this labour reconfigures interdependencies between International Organisations and hence the field of transnational governance itself. This is a novel, problem-driven perspective that goes beyond the role and impact of International Organisations through ‘governing by numbers’: instead, we bring together multiple bodies of knowledge in order to cast light on the role metrics play in re-shaping the data collectors themselves. Hence, focusing on the policy areas of Education and Development, this is an interdisciplinary study of the ways International Organisations co-exist, compete and survive in an increasingly quantified yet uncertain world. Building on International Relations theory, Science and Technology Studies, and using theoretical perspectives from Organisational Sociology, as well as the newly emerging field of the social studies of metrics, this research will apply a mixed-methods research design to examine the interrelationships of International Organisations in co-constructing the global metrological field.

Keywords: quantification,metrics,measurement,indicators,numbers,interdisciplinarity,sociology,mixed methods,statistics,international organisations,education,sustainable development
Understanding food value chains and network dynamics (VALUMICS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive agri-food sector for a safe and healthy diet
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Ireland,Austria,Germany,Germany,Iceland,Belgium,Finland,Sweden,China,Norway,Finland,Romania,France,Czechia,United Kingdom,United Kingdom,Viet Nam
Call: Understanding food value chain and network dynamics (H2020-SFS-2016-2, 2016)
Start date: 2017-06-01
End date: 2021-09-30
Duration (months): 52.0
Total project cost (EUR): 6327922.49
EU funding (EUR): 5999999.99
Participants: 22
Project status: CLOSED

The overall objective of the VALUMICS project is to provide decision makers throughout food value chains with a comprehensive suite of approaches and tools that will enable them to evaluate the impact of strategic and operational policies, and enhance the resilience, integrity and sustainability of food value chains for European countries. The consortium driving this proposal has a core of 19 European partners from 14 countries, and two Asian partners. Given the complexity and diversity of food value chains, and the contexts within which they operate, the VALUMICS project offers a comprehensive and multi-dimensional scope that will go beyond the current state of art to provide new approaches and tools for stakeholders on several fronts. This includes new modelling approaches, consumer research, foresight analysis and synthesis into policy options, adding new perspectives for policy makers, both in government and within the food industry sector. The dynamics within the food systems will be modelled using a causal loop analysis framework, covering the interconnected value, supply, and decision chains. The causality dynamics framework for the VALUMICS project methodological approach will be implemented as a key driver of the project work through workshops involving stakeholders. The causal loop framework will be built with involvement of all participants in the project in order to construct a shared vision of the overall system. VALUMICS will challenge and go beyond previous research limitations and boundaries through a highly cross-functional project design that will provide a bridging analysis across the economic, environmental and social dimensions previously kept separate. This whole chain analysis perspective will deliver comparative assessments at the European level and beyond. The case studies will cover short supply chains, with local and national analysis, as well as reaching global food chains relevant for sustainable food and nutrition security in Europe.

Keywords: agricultural economics,policy,value chains,sustainability,resilience,equity,integrity,food system dynamics,consumer,logistics,forecasting,modelling,supply chains,local,global
Search for New Phenomena, Materials and Applications Using Van Der Waals Assembly of Individual Atomic Planes (VANDER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-05-01
End date: 2025-04-30
Duration (months): 72.0
Total project cost (EUR): 2499580.0
EU funding (EUR): 2499580.0
Participants: 1
Project status: SIGNED

Many layered materials can be disassembled into isolated atomic planes, similar to graphite that splits into graphene layers. A few years ago, we demonstrated that such atomic planes – two-dimensional (2D) crystals – can be stacked on top of each other making so-called van der Waals (vdW) heterostructures. This has ignited a new field that is booming and has not disappointed in delivering interesting science. However, research efforts have so far involved only relatively simple structures that are assembled from 2 or 3 crystals and employ only a very limited number of 2D materials. This proposal is based on several recent experimental and technological advances by the applicant’s group. These include access to many new 2D crystals that have become available if their (dis)assembly is done in an inert atmosphere. Little remains known about these materials. We have also mastered the art of vdW assembly to make heterostructures containing dozens of different layers with control of their crystallographic alignment. Dedicated measurement techniques aimed at investigation of the resulting atomically thin structures and devices have been developed, too. The applicant plans to exploit these advances and push the research field forward in several new directions that include the search for 2D materials exhibiting unusual properties and novel functionalities, creation of multilayer vdW devices with designer characteristics and the assembly of artificial thin films with unique electronic spectra. Some of the proposed directions (e.g., studies of molecular transport through angstrom-scale capillaries) are nearly guaranteed to bring a large amount of new science and potential applications, whereas other directions (e.g., artificial films exhibiting enhanced superconductivity) are more adventurous. A unifying goal of all the proposed projects is to explore the myriad of exciting opportunities opened up within the field of 2D materials and vdW heterostructures.

Keywords: 2d materials,graphene,van der waals heterostructures