Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
eleCtRonic-based sYSTems reseArch exceLLence IN Europe (CRYSTALLINE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Austria,France,Germany,Italy,Poland,Spain,Sweden,Türkiye,Denmark,Slovakia,Luxembourg,United Kingdom,Czechia
Call: MSCA COFUND 2022 (HORIZON-MSCA-2022-COFUND-01, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2419200.0
EU funding (EUR): 2419200.0
Participants: 32
Project status: SIGNED

The mission of CRYSTALLINE (eleCtRonic-based sYSTems reseArch exceLLence IN Europe) is to train junior scientists (JSs) as future leaders in Electronic Based Systems (EBSs) research. Teaming up with three Austrian universities and drawing on their individual curricula, the Silicon Austria Labs (SAL) will offer JS positions in its entire EBS research portfolio scope, ranging from electronic components, via devices drawing on micro- and nanoelectronics, up to designs at the system or even system of systems level – and where electronics and embedded software meet to form the technological backbone of digitalization. The JSs becoming full SAL employees and being fully embedded into SAL’s research environment, CRYSTALLINE will offer them a global picture of EBS research perspectives and connections to SAL’s (inter-)national academic and industrial innovator network. For fostering their career development, the research topics will be fully aligned with the regional academic and industrial technology clusters’ agendas, with SAL’s three sites across Austria (Graz, Linz, Villach) multiplying the options available to the JSs. Complementing our dedication to research, we will train the JSs in essential transferable skills like communication, (project) management or ethics, and will offer secondments in our international network. Scientific forums, summits, social activities and networking days will be just some of the means in CRYSTALLINE to propel excellence and evolution in our JSs’ studies. In the proposed 60-month MSCA-COFUND action, we plan to attract 2 cohorts of 9 JSs for 48-month PhD studies. Via this action, we will be able to improve on our critical mass and our impact on EBS research at the highest level of scientific excellence. CRYSTALLINE will foster a brain-gain by attracting international talents to join the SAL network, and in turn international scientists can benefit from our SAL environment that unites academic excellence with industrial entrepreneurship.

Keywords: electronic based systems embedded systems intelligent wireless systems microsystems power electronics sensor systems
In Silico Trials for Cartilage Regenerative Medicine Applications (INSTant CARMA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2212385.0
EU funding (EUR): 2212385.0
Participants: 2
Project status: SIGNED

Osteoarthritis (OA) is a highly prevalent disease, affecting 1 in 8 adults worldwide and is projected to increase by 60% in the next two decades. Due to the intricate interplay between multiple influencing factors such as mechanical loading and inflammation playing out over multiple length scales and tissue compartments, currently no disease-modifying drugs are available on the market. The INSTAnt CARMA project aims to harness the power of in silico trials to study OA onset and progression, as well as design endogenous (drugs) and exogenous (tissue engineered) therapies. A multiscale multifactorial in silico model of the knee joint will be established and validated with dedicated in vitro and in vivo experiments. A continuous effort following targeted and untargeted approaches will take place to explore biological hypotheses and implement relevant model extensions. In parallel, computational upscaling tools will be implemented to prepare the model for execution of in silico trial simulations on virtual patient cohorts. The first in silico trial will investigate the effect of model-predicted drug combinations after experimental confirmation in a rodent model. The second trial will seek to optimize tissue engineered constructs for deep osteochondral defect regeneration, followed by experimental validation in a small and large animal model. To realize its goals, INSTAnt CARMA can build on the well-received and published work on a wide range of in silico, in vitro and in vivo tools developed by the applicant and her team. Additionally, the work will benefit from the applicant’s extensive network and involvement in regulatory science for in silico medicine. This project will further accelerate the uptake of in silico testing strategies in the development of medical therapies in general and osteoarthritis in particular.

Keywords: in silico medicine,osteoarthritis,tissue engineering,advanced therapy medicinal product,computer modeling and simulation
Nanoscale dynamics of volcanic processes: Experimental insights and numerical simulations of explosive eruptions (NANOVOLC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany,Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1999073.39
EU funding (EUR): 1999073.39
Participants: 2
Project status: SIGNED

Volcanism is virtually ubiquitous in space and time across the universe. Its explosive expression impacts planetary evolution, life and history on Earth. The brittle – molecular – failure of magma is central to trigger explosive eruptions and yet, its occurrence is elusive to us. The mechanistic understanding of magma dynamics, combined with monitoring activities, form the basis for forecasting eruptions. This is central for modelling the impact on volcanic eruptions and determining the risk scenario in populated areas and along flight routes. A lack of understanding of magma failure thus hampers our ability to study the local and global impact of volcanism. It is only in the last years that nanosized crystals (nanolites) have been exponentially identified in products of explosive eruptions. Pioneering experiments and in situ observations of magmas dynamics, I showed that nanolite formation can occur within seconds and has the potential to set the conditions for brittle magma fragmentation. It is time to observe in situ, under volcanic conditions the formation of nanolites and unravel their role in triggering explosive eruptions. This cutting-edge approach requires interdisciplinary research combined with technological advances. Through NANOVOLC, I will integrate earth sciences with materials science and artificial intelligence to lift the veil on the process of nanolite formation and its role in magma failure. I will deliver a numerical model of magma ascent and eruption to forecast and quantify the impacts of explosive eruptions. To this end, I will i) perform in situ observations of nanolite formation in magmas, ii) build a unique magma fragmentation apparatus that will push the experimental boundaries explored so far, and iii) use artificial intelligence to support numerical model of non-linear volcanic processes. Beyond volcanology, NANOVOLC will provide fundamental understanding of nanocrystal formation in technical glasses, relevant to glass-ceramic industry.
Assessment of ecotoxicity of novel materials for paper PCB based on SSdB (CircEl-Paper Hop-On)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Germany,Poland
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 27.0
Total project cost (EUR): 318093.75
EU funding (EUR): 318093.75
Participants: 2
Project status: SIGNED

The project CircEl-Paper deals with the development of paper-based high-performance Printed Circuit Boards (PCB) with a special focus on the development of new or enhanced recyclable or biobased materials. The project is designed to close the loop of circular economy. In order to accelerate the modification of materials suitable to realize the circular economy approach for PCBs, the CircEl-Paper Hop-On activity enforces the assessment of (modified) materials with regard to ecotoxicity in an early development stage. This mainly refers to the impact on environment, in case the materials unintendedly leave the recycling loop. Therefore, cost-effective computational methos for the environmental safety assessment are developed. This activity contributes to the SSbD framework (Safe and Sustainability by Design). Based on these assessments, CircEl-Paper partners that deal with material development receive guidance and recommendations. The assessments are based on enhanced computational models for structure-activity relationships designed and operated at QSAR. The work is focused on the material classes that are investigated in the CircEl-Paper project, such as modified paper, electronic inks, adhesives and chemical auxiliaries. The results are also linked to the intensive work of Life Cycle Analysis (LCA) as performed in the mother project since data interfaces between the LCA and other tools are developed. Therefore, an additional task is added to the CircEl-Paper project and supports and guides the consortium activity. It is carried out by QSAR, a polish company.

Keywords: ssdb,ecotoxicity,pcb end of life
A Revolutionary Tech for Exceptionally Efficient Natural Muscle Tissue Growth in Cultivated Meat Applications (PROFUSE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Transition Open 2023 (HORIZON-EIC-2023-TRANSITION-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 2432030.0
EU funding (EUR): 2432030.0
Participants: 1
Project status: SIGNED

Whilst meat demand is expected to double by 2050, consumption needs to drop by 50% to reduce greenhouse gases and preserve land. Cultivated meat - meat products manufactured through the harvesting and proliferation of animal cells - offers a feasible alternative, supplying animal protein at minimal environmental costs. However, the industry faces significant challenges linked to production costs, ability to scale-up, and final product quality. The main technical bottlenecks arise from the need to continuously source cells from live animals, and inefficient differentiation and maturation processes, that fail to achieve nutritional and organoleptic characteristics to satisfy consumers. Harnessing unique expertise on muscle cultivation, ProFuse has developed the first spontaneously immortalized and stable myoblast cell line (bovine) with remarkable proficiency in both muscle tissue proliferation and differentiation. Secondly, ProFuse has formulated a media supplement capable of driving the highly effective fusion and maturation into contractile muscle, successfully mimicking natural muscle development. After receiving the licensing of the patent protecting the discovery and the incorporation of our start-up for boosting development and commercialization, our team has established strong relationships with worldwide leading cultivated meat producers and suppliers, developing initial supplement formulations for different 2D and 3D applications. Through this project, we aim at optimizing our combined cell-line + supplement solution for scale-up enabling 3D production techniques up to reaching the validation in relevant environment with at least 3 potential clients while preparing the certification dossier, thus bringing our combined cell-line + supplement solution to TRL6. ProFuse will transform the scale-up potential and quality of final cultivated meat products, fast forwarding the industry to high uptake scenarios.

Keywords: alternative protein source,muscle growth,differentiation media,spontaneously immortalized cells,myoblast cell line,protein content,cultivated meat
Value-driven AI-enhanced Construction Waste Management (iCWaste)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Construction waste (CW) is a significant issue for environmental sustainability and economic efficiency. In the UK, construction, demolition, and excavation waste made up 62% of the total waste generated, amounting to 137.8 million tonnes​. Across the EU, construction and demolition waste represented the largest waste stream, with 374 million tonnes recorded. While recovery rates are high, much of this waste ends in landfills or is repurposed in low-grade applications, highlighting the need for improved recycling quality to better align with circular economy principles that advocate for the reuse and recycling of waste. Effective management of construction waste not only supports sustainable practices but also contributes to achieving the UN Sustainable Development Goals (SDGs), particularly SDG 12, which emphasises responsible consumption and production. Our research project is at the forefront of advancing sustainable construction by leveraging cutting-edge AI technologies and innovative waste magement strategies. The project aims to advance sustainable construction by leveraging AI technologies. It will precisely determine construction waste at the project level, identify waste generation points, and develop effective waste handling strategies. The project will also develop new KPIs for construction waste management to assess the efficiency of waste handling practices, resource utilisation, and project sustainability. Additionally, AI-driven decision-support systems will be developed to provide actionable insights for construction managers. The project emphasises sustainable construction practices, including materials reuse and building design for disassembly and reassembly. It will also establish guidelines, best practices, and policy frameworks to facilitate the adoption of sustainable construction methods across the industry. The project aims to catalyse a global shift towards resilient and sustainable construction in the UK, EU, and beyond.

Keywords: waste management intelligent decision making sustainable construction artificial intelligence
ULTRA-SOUND COMBINED WITH BIA AND GRAPHENE FET-ENHANCED WEARABLE SENSING FOR DECENTRAL HEALTH-MONITORING (UltraSense)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Greece,Finland,Spain,Poland,Slovenia,Czechia
Call: Smart sensors for the Electronic Appliances market (RIA) (HORIZON-CL4-2023-RESILIENCE-01-TWO-STAGE, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 8070607.36
EU funding (EUR): 6984473.0
Participants: 10
Project status: SIGNED

The prevalence of overweight among the European population is estimated to be near 50% and the prevalence of obesity around 16%. Monitoring obesity and overweight prevalence is important for assessing interventions aimed at preventing or reducing the burden of obesity and related medical risks and providing the tools for maintaining a healthier lifestyle. UltraSense project introduces the concept of a stretchable multi-sensing platform, as a wearable tool for body composition analysis and overall decentral health monitoring, fostering a sustainable and healthier lifestyle. The platform will comprise smart features, AI signal processing and advanced stretchable materials, enabling the efficient synergy of three compartments of sensors relying on different technologies: A. Ultra-sound compartment: delivering precise information about body composition and tissue thickness B. Bioimpedance compartment: fast and reliable measuring of the percentage of fat, water and muscle C. G-FET biosensor compartment: Biomarker retrieval via sweating at atto-Molar sensitivity in miniaturized footprint The wearable device will be validate in two use cases: 1. The effect of sport on a healthier lifestyle: monitoring the overall health of people who exercise 2. Early detection and continuous monitoring of metabolic syndrome. Ultra-Sense's data will be displayed to the user with consistency and reliability, so that medical advice can be sought. The green and circular material synthesis approaches of the project will reduce the related CO2 emissions by more than 70% from solvent processing. UltraSense will have a huge societal and economic impact: 700k devices will be sold annually already by 2032 for 105M€ of revenues reaching a 10% market share and associated with 20 new jobs. Millions of people will have access to low-cost, easy to use device informing of their body composition helping them improve their lifestyle, reducing obesity and metabolic diseases, and related treatment costs.

Keywords: wearable electronic devices,graphene,additive manufacturing,digital fabrication,green materials
Deciphering Cellular Networks for Membrane Protein Quality Control Decisions (DeCoDe)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1975000.0
EU funding (EUR): 1975000.0
Participants: 1
Project status: SIGNED

Any cell and each of its organelles needs to interact with its environment. Membrane proteins, which span the plasma membrane and the multiple endomembranes of a eukaryotic cell, mediate these interactions. They allow cells to move, thrive and defend - and multicellular organisms to exist. Humans dedicate almost one third of their genes to membrane proteins. Failures in membrane protein biogenesis or function cause numerous human diseases from cancer to neurological disorders. By far most eukaryotic membrane proteins are produced at one organelle, the endoplasmic reticulum (ER), where a dedicated protein folding and quality control machinery supports and controls protein structure formation. In contrast to our comprehensive understanding for secreted proteins, our understanding how cells support and control the biogenesis of membrane proteins is still limited. To further advance our understanding in this key area in molecular cell biology is the major aim of this proposal. Using recent biochemical and cell biological techniques combined with newly developed tools, we will address the following major questions: How do cellular quality control factors determine the folding state of a membrane protein? Which molecular signatures underlie the decision to chaperone or to degrade a membrane protein? How do chaperones collaborate in membrane protein biogenesis? Which further membrane protein chaperones and quality control factors exist in the mammalian ER? Answers to these questions will be major steps forward in our understanding of the inner workings of cells but also of the mechanisms underlying membrane protein-associated diseases. Three objectives will serve this goal: Objective 1: Define signatures of intramembrane quality control decisions Objective 2: Dissect chaperone synergies in membrane protein biogenesis Objective 3: Identify novel membrane protein chaperones by functionally validated interactome analyses

Keywords: membrane proteins,chaperones
Botanical Concrete: new green material for Artificial Reef (BCARE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-12-30
End date: 2026-12-29
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 1
Project status: SIGNED

Tourism, recreation, fishing, marine aquaculture, and many other economic activities depend on the diverse marine ecosystems globally. However, a combination of factors such as global warming, ocean acidification, and increment of cyclones in recent years have led to the aggravating degradation of natural reefs, one of the most varied marine ecosystems on Earth. Artificial reefs (AR) are widely used for habitat restoration, ecological development, and coastline protection. Concrete is the most successful AR material, but it generates substantial CO2 emissions, has high contamination, and has low bio-receptivity. Botanical concrete developed by author during PhD study is based on the concept of a circular economy with 100% responsible use of waste materials and its carbon negative and non-toxic characteristics provide exciting potential in building the green infrastructure in ocean. This research aims to enhance the durability, bioreceptivity and versatility of wood-waste-based botanical concrete to create a green route for the design of the new generation of multifunctional eco-friendly AR for coastal protection and coral restoration. Based on nutrition, water quality and settlement substrate test in marine environment (lab-level) the raw materials are selected. Followed by formation design through advanced simulation, Computed Tomography scanning and experiments on durability and mechanical performance, and life cycle assessment, the prototype of AR will be tailored to achieve optimal density for easy installation, high resilience in storms, superior capability for coral larval settlement and biodiversity. The results will revolutionize the way in which ARs are made and boost the efficient use of recycled resources and alleviate climate change by moving into a clean circular blue economy. The project will contribute to the EU’s sustainable blue economy strategies, including decarbonization, circular economy, biodiversity, climate adaptation, and sustainable food.

Keywords: botanical concrete artificial reef recycled carbon negative toxic free multifunctional eco friendly biodiversity durability optimal design lca ct scan coral restoration