Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
European Science Cluster of Astronomy & Particle physics ESFRI research infrastructures (ESCAPE)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: EOSC ecosystem
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Italy,Italy,Germany,Germany,Germany,Germany,Germany,Germany,Spain,Italy,Italy,Switzerland,Belgium,France,France,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Connecting ESFRI infrastructures through Cluster projects (H2020-INFRAEOSC-2018-2, 2018)
Start date: 2019-02-01
End date: 2023-01-31
Duration (months): 48.0
Total project cost (EUR): 15983301.25
EU funding (EUR): 15983301.25
Participants: 36
Project status: CLOSED

ESCAPE (European Science Cluster of Astronomy & Particle physics ESFRI research infrastructures) aims to address the Open Science challenges shared by ESFRI facilities (SKA, CTA, KM3Net, EST, ELT, HL-LHC, FAIR) as well as other pan-European research infrastructures (CERN, ESO, JIVE) in astronomy and particle physics. ESCAPE actions will be focused on developing solutions for the large data sets handled by the ESFRI facilities. These solutions shall: i) connect ESFRI projects to EOSC ensuring integration of data and tools; ii) foster common approaches to implement open-data stewardship; iii) establish interoperability within EOSC as an integrated multi-messenger facility for fundamental science. To accomplish these objectives ESCAPE will unite astrophysics and particle physics communities with proven expertise in computing and data management by setting up a data infrastructure beyond the current state-of-the-art in support of the FAIR principles. These joint efforts are expected result into a data-lake infrastructure as cloud open-science analysis facility linked with the EOSC. ESCAPE supports already existing infrastructure such as astronomy Virtual Observatory to connect with the EOSC. With the commitment from various ESFRI projects in the cluster, ESCAPE will develop and integrate the EOSC catalogue with a dedicated catalogue of open source analysis software. This catalogue will provide researchers across the disciplines with new software tools and services developed by astronomy and particle physics community. Through this catalogue ESCAPE will strive to cater researchers with consistent access to an integrated open-science platform for data-analysis workflows. As a result, a large community “foundation” approach for cross-fertilisation and continuous development will be strengthened. ESCAPE has the ambition to be a flagship for scientific and societal impact that the EOSC can deliver.

Keywords: open science,astronomy,particle physics,esfri,km3net,hl lhc,fair,cern,jive,virtual observatory,eosc,citizen science,data lake,big data
NOx Conversion (NOx Conversion)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Crop Intellect Ltd have conceived and proved an innovative technique to capture NOx and convert it to nitrates for use in agriculture. It is for the first time, NOx have been demonstrated as substrates for production of nitrate fertiliser directly on crop foliage. Competitive advantages of the technology include: (i) leading to application of no N fertilisers to crops. This will save money and increase crop yields whilst protecting the environment; (ii) generating cost savings of 68.70% to the farmer compared to current practices of N fertiliser application as well as generating extra revenue of €1,616/ha to the farmer; and (iii) using atmospheric NOx as substrates for production of N fertiliser can help mitigate nitrogen pollution. Nitrogen pollution is a significant environmental problem in Europe and around the world as its impacts include contributions to global warming. The total annual cost to the EU of nitrogen pollution’s environmental impacts is €70–320 Billion. To address this problem the EU have introduced directives, such as 2001/81/EC and 2008/50/EC. In industrial facilities, there are severalmethods for controlling NOx emissions. Although these technologies exist, they can’t directly be used in agriculture as methods for controlling or mitigating NOx emissions or utilise NOx as resources for improving crop growth and yield.

Keywords: nitrogen pollution,nitrogen oxides nox,nitrogen fertiliser efficiency,removal of nox,conversion of nox to nitrates,sustainable agriculture
The Clinical Flexible Analyzer- a new generation IVD testing device aimed to increase the competitiveness of local healthcare vs. large laboratories (CFA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-11-01
End date: 2019-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Increasing population and rise in chronic diseases have led to an enormous demand for faster and better in-vitro diagnostic tests of parameters for improved detection and cure of diseases. However, there is significant fragmentation and separation in the IVD immunochemical analyzers market, depending on the end users’ size: on one hand there are large workstations (analyzers) capable of analyzing several parameters in one device, which are extremely large and pricey, and on the other hand, there are stand-alone devices with much narrower parameter testing, low throughput and efficiency, which are mainly based on 30 years old technology. These latter are the only option for smaller local clinics, which cannot afford the large, combined workstations, and thus, lose competitiveness to large laboratories who can afford them. Our company, MEON Medical Solutions, is an Austrian based SME specialized in developing IVD medical devices for measurement of vital parameters to support medical professionals in clinical diagnostics. Our over 30 years of experience in the field enabled us to identify the business opportunity derived from the needs of small clinics and laboratories, for which we have developed the CFA – Clinical Flexible Analyzer- i.e. an innovative, automated, all-in-one immunochemical analyzer that combines the three most demanded diagnostic methods - Clinical Chemistry, Heterogeneous Immunoassays and Ion Selective Electrodes - in a single small modular, highly flexible and cost-efficient device. The CFA will enable small laboratories to provide an extremely cost-efficient local healthcare, and boost the growth of our company: We have estimated that after 5 years of CFA’s commercial launch in 2022, we will have engaged into 1,000 small clinics and hospitals globally, boosting the economic growth of our company, and enabling us to achieve a leading position over all other competitors.

Keywords: analyzers,clinical chemistry,immunoassays,all in one,in vitro diagnostics
Multi-Axial Magnetic Field RHEology (MAMFRHE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-13
End date: 2024-09-12
Duration (months): 36.0
Total project cost (EUR): 245732.16
EU funding (EUR): 245732.16
Participants: 2
Project status: SIGNED

The full rheological response of magnetorheological (MR) fluids will be investigated under unsteady multiaxial magnetic fields for the first time. Such fields are able to drive the MR fluid to minimum energetic states. Thus, we hypothesize that the superposition of multiaxial fields will constitute a relatively easy and straightforward mechanism to optimize MR fluid performance (contrary to current optimization routes, mainly based on complex schemes to tailor MR fluid constituents). The project will assess the MR fluid behavior in both pre-yield and post-yield regimes. In the two cases, bulk rheological properties (viscoelastic moduli, viscosity and normal stresses) will be investigated in terms of the particle microscale structure and dynamics, formation of percolating particle networks at rest or (expected) lamellar structures under steady flow. To do so, the problem will be tackled firstly from a numerical point of view at the Partner Organization. MR fluids will be modelled implementing direct contact forces between particles, hydrodynamics and unsteady magnetic multiaxial interactions using Molecular and Stokesian Dynamics. Secondly, the results from these computational studies will be corroborated through experiments at the Hosting Institution using a custom-built high-speed confocal magneto-rheomicroscope. This consists of a high-speed confocal rheomicroscope coupled to a unique magnetic field generator that allows, at the same time, visual access to the sample and the generation of unsteady multiaxial fields. With this novel and comprehensive project, it is intended to open a new branch in the magnetorheology research field, testing the ability of multiaxial fields to improve MR performance and promote their exploitation in novel or current applications.

Keywords: magnetic colloids,rheology,experimental colloidal physics
Unlocking the potential of ultrahigh field 23Na magnetic resonance to quantify tissue sodium content for probing viability of the heart: where physics, biology and medicine meet (SODIUMMRI-4-EU)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Cardiovascular diseases (CVD) are the leading cause of death with 60% of CVDs associated with coronary artery diseases (CAD). CAD is the major cause of myocardial infarction (MI), commonly known as heart attack, which can be life threatening and places a huge socio-economic burden on the EU. The most widely used therapy for CAD is revascularization, and myocardial viability is a determining factor and predictor for patient outcomes. Magnetic resonance imaging (MRI) has become a mainstay of clinical diagnosis, but so far has seen limited use in the study of the heart. Here I aim to unlock the potential of myocardial viability imaging with physiometabolic MRI to provide a new instrument for the diagnosis and assessment of therapy success of CAD. Therefore I propose a quantitative approach based on MRI of sodium (23Na) that will allow me to observe new features of the working heart, at a level of resolution that will be highly valuable in understanding, finely diagnosing, and designing treatments for CVD. To meet this goal I pursue the development of cutting edge sodium MRI technology. Its capacity for quantitative assessment of sodium tissue content will be validated in model systems and in healthy subjects. The clinical applicability of 23Na MRI for viability imaging will be examined in revascularized MI patients. For this purpose I will leverage the sensitivity gain inherent to ultrahigh field MRI (B0≥7.0 T), capitalize on my outstanding expertise in the field of physiometabolic MRI and build on my interdisciplinary skills formed around MRI physics. In this project, this expertise will be taken to the next level to elucidate the progression of sodium concentration in ischemic myocardial tissue. This research will eliminate the main barriers to the study of tissue viability and will open entirely new possibilities for non-invasive, in vivo phenotyping as a tool for individualised medicine tailored to offset a major socio-economic burden on the EU induced by CVD.

Keywords: tissue viability imaging,sodium magnetic resonance imaging,at ultra high field strength
Luxembourg EU Presidency Conference 2015 on MSCA COFUND, 10-11 December 2015 (MSCA2015 - COFUND)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Action type: Coordination and support actions
Countries involved: Luxembourg
Call: MSCA (H2020-Adhoc-2014-20, 2015)
Start date: 2015-07-01
End date: 2016-01-31
Duration (months): 7.0
Total project cost (EUR): 191250.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Under Luxembourg's EU presidency in the second half of 2015, the National Research Fund (FNR) is organising a high visibility international conference on the theme of COFUND in the framework of the Marie Sklodowska-Curie Actions. The conference will take place December 10-11, 2015, in the premises of the Chamber of Commerce at Luxembourg-Kirchberg. On the evening of December 10, the Marie Sklodowska Curie Award Ceremony will be organised in the prestigious Cercle Cité in Luxembourg City. The event will be framed by a Keynote followed, and by a Gala dinner. A total of 150-200 participants are foreseen. A call for contributions will invite stakeholders all over Europe to contribute their experiences to the conference, in order to take stock of experiences with the MSCA COFUND so far, and to formulate recommendations for the future of the MSCA COFUND under H2020. A website, a logo and the visual identity of the conference will be developed. Information regarding the conference, the programme, organisational issues, information about speakers, keynotes and MSCA award winners (including a short film per awardee), as well as the final conference report and recommendations will be widely disseminated through the conference dedicated website www.msca2015.lu. The overall budget of the conference is approx. 190.000 EUR. The EU contribution requested amounts to 150.000, while the remaining part is covered by the FNR.

Keywords: luxembourg eu presidency,msca,international conference,msca 2015 cofund
How retrotransposons remodel the genome during early development and reprogramming (TransposonsReprogram)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2023-09-30
Duration (months): 89.0
Total project cost (EUR): 1499055.0
EU funding (EUR): 999137.0
Participants: 2
Project status: SIGNED

Retrotransposons (RTNs) are ancient viruses that have stably integrated themselves into mammalian genomes and they now occupy around half of the human or mouse genome. These mobile genetic elements that have coevolved with us drive evolution by creating new genes and plasticity of genomes. Exciting data including ours has shown that even RTNs that are no longer active retain enhancer, promoter or repressor sequences that regulate developmental genes, through largely uncharacterized transcription factors. We have employed CRISPR/Cas9 gene disruption to determine that Zfp37 and Zfp819 bind to and regulate RTNs in mouse embryonic stem cells (ESCs). Identification of these zinc finger proteins (ZFPs) now allows us to ask new questions about how RTNs have been co-opted to orchestrate gene circuits in vitro and in vivo. Both these factors have already been implicated to play a role in reprogramming or genome integrity. We hypothesize that RTNs have been co-opted to remodel the genome by acting as structural platforms that recruit transcription factors like Zfp37 and Zfp819. We will test this hypothesis assessing the role of RTNs and these two ZFPs in three dynamic contexts where the genome is remodelled. These are in ESC differentiation to neurons, in reprogramming and in early mouse development, three scenarios where RTNs have been documented to become expressed and serve an unknown function. This work will exploit mouse development to unravel the mechanism of how RTNs remodel the genome. It will help us to understand how ZFPs can be engaged to reprogram cells and in stem-cell therapies, and will explain more broadly how RTNs, which dominate our genomes, control cell fate.

Keywords: retrotransposons,gene regulation,reprogramming,embryonic stem cells,neural differentiation,early mouse development,epigenetics,novel zinc finger transcription factors
Treatment of traumatic brain injury using dye-loaded polymeric nanoparticles (NEUROTARGET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-12-01
End date: 2020-11-30
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Traumatic brain injury (TBI) is the number one cause of disability in children and young adults. Despite well-known mechanisms of secondary brain damage after TBI, effective treatments have not been yet established. Consequently, novel strategies to develop therapeutics which have translational potential are urgently required. One of the major obstacles when trying to treat the brain is the inability of drugs to cross the blood-brain barrier (BBB). Therefore, it is of great importance to develop novel strategies of drug delivery to targeted locations across the intact BBB. Poly(lactide-co-glycolide) nanoparticles (PLGA NP) are safe and biodegradable drug carriers. When coated with poloxamer188, they are able to cross the BBB. However, the exact mechanisms of penetration, as well as their route to target cells in the brain are currently unknown. To investigate this, the applicant will combine three cutting-edge technologies: novel extra-bright PLGA NP, in vivo two-photon microscopy and whole body clearing (uDISCO). These techniques in combination allow 3D visualization at the sub-cellular level of how PLGA NP distribute throughout the body, cross the BBB and release their cargo in vivo. These NP will subsequently be used as carriers to deliver multiple neuroprotective compounds with synergistic action into the brain. This technique allows high specificity and potency of therapeutic compounds, while minimizing the risk of side effects. Ultimately, objective of this approach is to create an optimal novel nano-platform for brain-targeted drug-delivery and based on this, to provide an innovative treatment of TBI that has the potential for clinical translation. Furthermore, the project will enable the applicant to gain extensive knowledge in advanced in vivo microscopy and TBI models, techniques that are well established in the host laboratory, thereby giving him the opportunity to become a leader in this novel field of research running his own research unit in the future

Keywords: traumatic brain injury,polymeric nanoparticles,brain targeted drug delivery,bio imaging,neuro nanomedicine
A Privacy-Preserving Marketplace for Slot Management (SlotMachine)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Austria,Austria,Switzerland,Belgium
Call: Future ATM Architecture (H2020-SESAR-2019-2, 2019)
Start date: 2020-10-01
End date: 2022-12-31
Duration (months): 27.0
Total project cost (EUR): 2202882.44
EU funding (EUR): 1937738.75
Participants: 5
Project status: CLOSED

The aviation industry is confronted with rising passenger numbers and increased flight volume in the face of limited resources at airports and in the air. At the same time, airlines struggle with increased cost pressure from an increasing number of market participants while the highest safety standards demand compliance with complex processes. One promising area of optimization is the allocation of Air Traffic Flow Management (ATFM) slots. ATFM slots are issued by the EUROCONTROL Network Manager in times of increased flight traffic, regulating time of departure, exact execution of the flight route, and time of landing. Until now, ATFM slots have only been subject to intra-airline swaps, used by airlines to prioritize expensive flights and thus minimize overall costs. Reasons for different costs of individual flights are, for example, the provisioning of connecting flights for passengers or work time restrictions for crew members. Airlines want to keep the cost structure of their flights confidential, as they fear a competitive disadvantage when disclosed. This desire for confidentiality has hampered slot swapping between different airlines. SlotMachine will employ blockchain technology and secure multi-party computation to extend the existing UDPP solution with the possibility to keep private the participating airlines’ confidential information such as the cost structure of flights. Technology will allow for secure, auditable transactions without the need for a central broker where stakeholders will be able to enter slot swapping transactions without disclosing information to other participants. By demonstrating the feasibility of a privacy-preserving platform for swapping ATFM slots, the foundation can be laid for the development of a product that will be an essential element in the aviation industry in the future. It contributes to better use of existing resources at airports, higher efficiency of airlines, lower emissions, and shorter delays for passengers.

Keywords: atfm,airline,airport,slot swapping,digital marketplace,data management,data exchange,data trading,cybersecurity,resilience