Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Global assessment of plant photosynthesis optimization for climate change versus enhanced plant productivity (PHOTOFLUX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2028-01-31
Duration (months): 64.0
Total project cost (EUR): 1499981.0
EU funding (EUR): 1499981.0
Participants: 1
Project status: SIGNED

Millions of years of evolution have produced extraordinary adaptations and solutions for plants to face the naturally excessive solar energy which commonly cannot be fully utilized by the light harvesting pigments of leaves. To find a balance between the harvesting of and the protection against the solar radiation conditions, all plants employ flexible thermal or non-photochemical energy dissipation mechanisms. Yet, inherent capacities for these flexible dissipation mechanisms differ between plant species and can change along seasonal conditions but also short-term physiological strain of the plants. The optimized balance between the photochemical and non-photochemical energy pathways of absorbed radiation is a very dynamic concept which remains physically poorly understood. Deriving these energy components and assessing them in a global context would greatly advance our knowledge on the basic energy functioning of vegetation, making room for possible improvements in food production or understand required capacities to cope with climatic changes. With the ambition to quantify actual photosynthesis from space for agricultural management units, ESA will launch in 2024 the FLuorescence Explorer (FLEX) as 8th Earth Explorer mission equipped with a novel sensor payload dedicated to the retrieval of solar-induced fluorescence and the reflectance at a high-spectral resolution. This proposal, named PHOTOFLUX, will take a novel approach to spectrally disentangle the photochemical and non-photochemical components of harvested light, building on a quantitative understanding of the energy partitioning within the light reactions. Not only will this strategy serve a bottom-up conceptual understanding of the photosynthetic light harvesting at global scale, it will also bring the possibilities to quantitatively assess productivity under the climatic constraints and the need to dissipate the excess energy to keep photosynthesis at optimal rates.
Simultaneous Multiparametric MEA based platform for in-vitro chronic cardiotoxicity assessment with live-cell fluorescence imaging and electrophysiology. (SiMulTox)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy
Call: EIC Transition Open 2021 (HORIZON-EIC-2021-TRANSITIONOPEN-01, 2021)
Start date: 2022-04-01
End date: 2024-06-30
Duration (months): 27.0
Total project cost (EUR): 786875.0
EU funding (EUR): 786875.0
Participants: 1
Project status: CLOSED

Cardiac drug-related adverse effects have been the major causes for the failure or withdrawal of drugs from the market. With a growing global market, cardiotoxicity still remains a bottleneck in the chain of drug development. Despite the large investments in drug discovery and development, the number of approved drugs has been declining. Current in-vitro technologies assess functional cardiotoxicity relying on short-term electrophysiological recordings (detection of cardiac Action Potentials, AP). However, drug toxic effects may manifest themselves in other ways such as morphological alterations, toxic chemical species generation or metabolic dysfunction. These effects are categorized as structural cardiotoxicity. Presently, functional and structural toxicities cannot be assessed simultaneously on the same cardiac cell culture in long-term experiments. This represents a substantial barrier to a deeper toxicity assessment. SiMulTox addresses this need with a novel platform for multiparametric detection of cardiac functional and structural toxicity. Starting from the unique laser-based technology of Foresee Biosystems, SiMulTox aims at developing an in-vitro platform that exploits a combinatorial approach of AP recordings and live-cell fluorescence imaging of the same cardiac cell culture. More importantly, it will provide these capabilities in extremely long tests (more than 1 month) that enable the assessment of chronic toxic effects. The final objective is the commercialization of a platform that will reshape the market of in-vitro cardiotoxicity assessment. The product will generate high demand for equipment in the markets of cardiac physiology, safety pharmacology, and drug development. In perspective, SiMulTox will pave the way also to new products for assessing functional and structural neurotoxicities simultaneously, allowing Foresee Biosystems to expand substantially its target market.

Keywords: in vitro cardiotoxicity,cell poration,action potential recording,fluorescence live cell imaging
Comprehensive methodological and operational approach to clinical trials in rare and ultra-rare diseases (RealiseD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Innovative Health Initiative
Action type: Research and Innovation actions
Partnership: IHI (JU-JTI)
Countries involved: Belgium,Netherlands,United Kingdom,Austria,Italy,Spain,Germany,France,Norway,Switzerland,Denmark,United States,Argentina
Call: : Establishing novel approaches to improve clinical trials for rare and ultra-rare diseases (HORIZON-JU-IHI-2023-04-two-stage, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 17227265.0
EU funding (EUR): 8500000.0
Participants: 53
Project status: SIGNED

RealiseD implements a collaborative and compRehensive mEthodological and operational Approach to cLinical trIalS in rarE Diseases enabling timely drug development and approval centred on patients’ needs with high level of evidence reachable in a limited environment. The core of RealiseD operational approaches includes the systematic procedures for patients’ referral, the certification of clinical sites and filling the gaps for successful development of rare and ultra rare diseases[(U)RD]’ clinical trials using 4 (U)RD diseases from 4 European Research Networks (ERNs). RealiseD methodological teams will optimise innovative statistical and quantitative approaches for design and analysis of (U)RD-CTs developed in the past 10 years and refined in the last years to facilitate the regulatory pathway for innovative drug development. RealiseD is implemented in a public private partnership consortium including regulators and HTA bodies representatives to co-create operational and methodological approaches in an iterative procedure using a multistakeholders’ agreement process. RealiseD will increase the incentives and motivation for the pharmaceutical industry by reducing many uncertainties on the path of drug development in (U)RD that will follow widely accepted rules. To achieve these innovative approaches, RealiseD will capitalise on an international multistakeholders effort as the problem in (U)RD drug development cannot be solved in a restricted geographical area. With the development and deployment of playbooks arising from the co-created developments, RealiseD will ascertain visibility and readiness of the innovations. The overall ambition of RealiseD is to change the paradigm of CT design for U(RD) by enlarging the spectrum of methodological and operational approaches and to establish a sustainable, innovative, and optimised CT paradigm for U(RD) medicinal product development programs, while maximizing the acceptance by all stakeholders.

Keywords: methods for drug development with ultra rare diseases
An Edible Microelectrofluidic Biosensor for Gastric Enzyme Quantification (EDISENS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

EDISENS will deliver the first edible microelectrofluidic biosensor for enzyme activity quantification in gastric fluid that the human body can digest after completing its task. This will be accomplished by integrating passive microfluidics, electronics, and bioreagents into an edible device fabricated with food-grade materials. The biosensor will find application in the detection of pancreatic diseases, including pancreatic cancer. Today, existing ingestible electronics represent a trillion-dollar market. Yet, they suffer from retention risk as they use non-degradable materials and heavily contribute to the accumulation of e-waste in the environment. EDISENS will deliver a safe-to-eat device performing a rapid accurate enzymatic test on gastric fluid before being digested that eliminates the retention risk and does not require hospitalisation and disposal. The proposed technology will be highly versatile and will be beneficial for applications beyond our immediate test case. The transition to edible alternatives will spark the next generation of diagnostic devices for gastrointestinal tract monitoring which are safer, non-invasive, environment friendly and can be used at the point of care. The project will start a change in the social perception of diagnostic devices, where safe and familiar materials can be engineered to provide non-invasive diagnostic tools: EDISENS works toward the vision that clinical testing will be as easy as eating candy one day. This action is in line with the Horizon Europe global challenges program that promotes advanced non-invasive safer health technologies and a greener and more sustainable European society. For the success of this action, the researcher will utilise his experience in standard point-of-care and ingestible electronics, exploit the supervisor’s expertise in organic and bioresorbable electronics and benefit from the state-of-the-art laboratory at the Center for Nano Science and Technology, Istituto Italiano di Tecnologia.

Keywords: edible electronics,edible bioengineering,organic electronics,microfluidics,enzymes,transistors
Rethinking Queer Kinship: LGBTIQ* Families with children in Central and Eastern Europe (QUEERSHIP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Studies of Cultures and Arts
Panel description: Social anthropology, studies of cultur es, stud ies of arts
Countries involved: Poland
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The marginalization of Central and Eastern Europe in queer kinship and family studies has created a critical gap in understanding global LGBTIQ* family dynamics. Dominant theories, shaped largely by Anglo-American contexts, often overlook the diversity of family structures and practices in other regions. QUEERSHIP addresses this gap through the first transnational, interdisciplinary study of queer kinship across Poland, Hungary, Czechia, and Croatia. QUEERSHIP aims to develop the Multidimensional Sociocultural Model of Queer Kinships, challenging dominant paradigms and broadening the understanding of family, kinship, gender, and sexuality. Unlike most scholarship, which often focuses on same-sex families or separately on trans experiences, QUEERSHIP adopts a holistic approach by studying LGBTIQ* families together, considering all identities and relational practices within one framework. It also employs a multi-actor perspective, incorporating the voices of significant others, activists, and professionals alongside LGBTIQ* families. Using a mixed and multi-methods approach, QUEERSHIP combines discourse analysis, longitudinal ethnography, focus group interviews, and a large-scale survey to comprehensively explore how LGBTIQ* families are formed, maintained, and displayed across diverse sociocultural and political landscapes. Additionally, it applies participatory action research to refine methods and keep the research responsive to participants' lived realities. By integrating diverse perspectives and employing a robust interdisciplinary framework, the project offers a groundbreaking approach that decentralizes and expands (queer) kinship and family studies. QUEERSHIP findings, innovative methodological approach, and the proposed MSMQK will impact scholarly debates in gender, queer and kinship studies, as well as postcolonial and post-socialist studies, paving the way for future research that better reflects the complexities of LGBTIQ* family lives.

Keywords: lgbtiq families,queer kinship,sexuality,gender,family studies,central and eastern europe
2PS - Prevent & Protect Through Support (2PS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Fighting Crime and Terrorism
Action type: Research and Innovation actions
Countries involved: Poland,United Kingdom,Sweden,Finland,Netherlands,Malta,Switzerland,Germany,Italy,Cyprus,Czechia,Belgium,Lithuania,Norway
Call: Prevention of child sexual exploitation (HORIZON-CL3-2021-FCT-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 2410866.25
EU funding (EUR): 2410865.5
Participants: 24
Project status: SIGNED

The European Commission’s latest strategy for fighting child sexual abuse highlights a harsh reality that, globally, we are ‘losing the battle’ against online child sexual abuse and exploitation (OCSEA). Various projects funded through the EU are working diligently to identify the source of CSAM on both the Clearnet and Darknet and are establishing stronger awareness of the needs and requirements of LEAs to fight the overloading volume of images, text, media files, etc. However, the IOCTA 2021 report also brings a chilling honesty that the prevalence of materials shows no sign of slowing or stabilising. The adage that prevention is better than the cure never seemed more fitting. The 2PS project condemns all forms of sexual abuse and exploitation – and there are no excuses that justify behaviours and actions that harm or victimise children. However, to reduce the number of abused children and those at risk of exploitation, we need to address various challenges. Several of those relate to people with a sexual interest in children and their needs to divert them from abusing. 2PS, which stands for Prevent & Protect Through Support is a highly innovative action offering a paradigm shift in the approach to tackling child sexual abuse and exploitation (CSAE) across Europe. The highly qualified and diverse consortium – together with leading global actors – are committed to laying the foundations for new coherent modus operandi that complement the reactive approaches currently favoured. This is achieved by addressing the support needs of people with a sexual interest in children and people who feel they might offend. We will share the best practices for guidance, therapy and treatment methods – combined with new training and awareness for frontline support workers and LEAs. We aim to move preventive actions to the forefront, offering alternative courses of action to existing offenders and people who fear they might offend– including people with a sexual interest in children.

Keywords: preventing child sexual abuse and exploitation csae
Emergence in Quantum Physics (EmQ)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Emergence is central to our understanding of the world. It addresses the question of how did a seemingly unlimited diversity emerge from a small number of simple constituents. Ultimately emergence in physics is related to an inaccessibility of knowledge about the microscopic world, out of which new phenomena are formed at a larger scale. In quantum physics the Renormalization Group is a prominent example relating microscopic physics to emerging new phenomena. The main thrust in the research proposed here is to experimentally study in full detail emergence in the quantum world, all the way from the microscopic physics of elementary (atomic) constituents to a hierarchy of effective models at large scales. A central objective will be to verify emerging models, probe the limits of their validity, when do they break down, and investigate how big a system has to be to show emergent phenomena. Ultra-cold atoms allow to implement and study complex, interacting quantum many body systems in detail and powerful manipulation techniques combined with the ability to measure each atom with close to unit efficiency offers an unprecedented way to probe the whole path of emergence from micro- to macro physics We will investigate three examples: (i) Emergence of quantum field theories as illustrated by the sine-Gordon model; (ii) emergence of universality as the system forgets its initial conditions in the course of non-equilibrium evolution; (iii) emergence of a hydrodynamic description in the non-equilibrium evolution of correlated quantum systems. We envision robust, verified emergent models to have numerous applications as quantum simulators ranging from solid state physics to aspects of physical system that are inaccessible for direct experiments. Moreover, emergence coming from inaccessibility of knowledge about the microscopic world may ultimately lead to a natural bridge between quantum and classical.

Keywords: emergence in quantum physics,quantum simulation,experimental models for quantum field theories,emerging hydrodynamics,measuring,probing and verifying quantum systems
Innovative and sustainable materials, processes and technologies for a GREENer and circular economy (GreenX3)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Spain,Italy,United Kingdom,Luxembourg,France
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 2961668.57
EU funding (EUR): 2630361.6
Participants: 16
Project status: SIGNED

GreenX3 is a multidisciplinary and innovative project designed to use chemical tools to address the current global environmental challenges. The research objectives will focus on: i) the study of greener materials including polymers, plastics, alternative feedstocks, natural substances and their environmental impact; ii) the development of novel environment-friendly industrial processes for isolation; iii) the recovery and production of these materials with key enabling technologies (KETs) designed to enhance resource management and product quality. The GreenX3 network will create a research and training environment supported by 16 teams (beneficiaries and associated partners) for the international, intersectoral and interdisciplinary training of 13 researchers equipped with multidisciplinary skills allowing them to work across disciplines, to gradually shape and lead to a greener and sustainable chemical industry within the Research & Development/Innovation framework. Six industrial pioneers offer the necessary skills to become the future ‘technology transfer’ experts thanks to the close and frequent exposure of the researchers to private sector and to KETs to significantly enhance their employability. Environmental and economical sustainability requires a multidisciplinary approach to fill the gap that is currently significantly limiting technology transfer from research to marketable innovation. The multidisciplinary expertise boosted by the presence of industrial partners, the main drivers of the scientific objectives to respond to a real gap in knowledge, with complementary knowledge, will offer a superior training opportunity. GreenX3 will contribute EU Green Deal by ensuring acquisition of the knowledge and skills needed to promote sustainable development through research and training for responsible production, sustainable management and efficient use of natural resources, reduced waste generation through prevention, reduction, recycling and reuse.

Keywords: ecotoxicity,green industrial processes,alternative feedstocks,advanced formulations,nano pharmaceuticals,drug delivery systems,microbiology