Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DIgitalization of ground-testing Life cycle with ECO design criteria (DILECO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Switzerland
Call: Development and deployment of PLM Tools for A/C Ground Functional testing with Eco-design criteria. (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2020-10-31
Duration (months): 32.0
Total project cost (EUR): 399912.5
EU funding (EUR): 399912.5
Participants: 3
Project status: CLOSED

DIgitalization of LIfe cycle ground testing with ECO design criteria. DILECO will contribute, from the scope of a Ground System Tests Station of a FAL, to the huge effort to maintain leadership in aviation industry while trying to adapt to new trends related to sustainability in global markets, by means of an eco-efficient production and digitalization of the factory. Many processes in the Ground System Tests (GST) Station of the Final Assembly Line (FAL) of an aircraft, present a relatively low grade of automatization, with a lot of room for improvement when it comes to digitalization and product PLM integration. The introduction of some of the aforementioned technologies in the modern FAL can definitely impact the factory’s lean manufacturing and the environmental sustainability of the whole process. Implantation of new assembly procedures can take advantage of commercially available technology, but also actual methods and procedures like the moving assembly line, visual control systems, point-of-use staging, just-in-time delivery systems, etc. can be significantly improved. The General Objective of this proposal is the Development and deployment of PLM Tools for A/C Ground Functional testing with Eco-design criteria in order to improve the sustainability of the FAL and the efficiency of the Ground System Tests process end to end. All the works will be done on site, in close contact with the Topic Manager, with as many revision cycles as possible before a final release.

Keywords: eco efficiency,mbse,rflp,collaborative engineering,digitalization,ontology and semantic modelling,ground systems tests
Triloci-seq - Dechipering the triple helix code (triloci-seq)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Israel,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-08-01
End date: 2022-07-31
Duration (months): 24.0
Total project cost (EUR): 181365.12
EU funding (EUR): 181365.12
Participants: 2
Project status: CLOSED

Recent technological advances revealed that there are many long non (protein)-coding RNA molecules (lncRNA) transcribed in the genome, many of whom regulate gene expression. However, it remains unclear how lncRNA molecule can interact directly with chromatin to regulate gene expression. One possibility that has been raised is via the formation of triple-helices. The potential for the formation of triple helices exists in any nucleic acid chain via an interaction called Hoogsteen base-pairing. However, unlike the genetic code or even Watson-Creek base-pairing, the triplex code or sequences which can function as triplex target sites and triplex-forming oligos is poorly understood. To decipher the triplex code in vivo, I propose a novel research approach based on next generation sequencing that I call Triloc-seq (in vivo). The feasibility this research plan relies on two crucial resources: first, mammalian genomes which can harbor as many as hundreds of thousands of putative high-affinity triplex target sites (TTSs), and second mixed-base oligo synthesis technology. Together these resources will allow us to over-come the greatest obstacle in triplex study, the need to match specifically a target site with its triplx forming oligo (TFO). To study the triple-helix code, we will transfect mammalian cells with a TFO libraries, and use click chemistry to join the TFO to its target site. We will then use previous TFO-TTS data obtained in vitro and multiple advanced bioinformatic approaches to extract the genomic TTSs. Finally, to prove that triplex interaction can be functional in vivo, we will design several applications that will test this functionality. In all cases we will design a cassette of known TTS target sites and position it upstream of a minimal promoter. The TTS cassette will be targeted by natural lncRNAs containing matching TFO segments, synthetic TFO-VP64 hybrids synthesized in vitro, and fluorescently labelled TFOs to confirm TTS-TFO functionality.

Keywords: synthetic biology,triple helices,hoogsteen interactions,lncrna
Rights for Ecosystem Services (RES): a framework to protect the environment and sustainable local communities in the EU. (RES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-13
End date: 2022-01-12
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Is currentIs current legal protection adequate to prevent local communities in the EU from abandoning their traditional and environmentally sustainable practices? Environmental protection is increasingly gaining recognition as essential for the fulfilment of human rights. However it remains unclear whether human rights offer sufficient protection for local communities that contribute to environmental protection. The project will break new ground compared to current scholarship, which focuses on indigenous peoples in developing countries. It will focus on non-indigenous local communities in the EU, investigating the intersection of international, EU and national law. The experienced researcher (ER) will build on her research on biocultural rights (monograph published by Oxford University Press) to develop an innovative theoretical and legal framework – Rights for Ecosystem Services (RES) – according to which local communities could be recognized the rights needed to maintain their sustainable practices, in so far as they are bound to remain sustainable. If the hypothesis is correct, RES would be ‘rights with duties’, leading to the identification of needed legal and policy changes to protect the environment and the interests of sustainable local communities. Methodologically, the ER will originally integrate: legal theory; analysis of international, EU and national law; conservation science; religious studies; empirical legal research (fieldwork). The ER will be supervised by Prof. Elisa Morgera (world-leading expert in international and EU environmental law and human rights) and hosted at Strathclyde Centre for Environmental Law and Governance (SCELG) - centre of excellence on human rights and the environment. SCELG will benefit from the ER’s expertise in legal theory, religious studies and conservation biology, and the ER will be engaged in embedded peer-learning and peer-review approaches to develop research, teaching, knowledge exchange, and policy advice skills.

Keywords: human rights,environmental protection,local communities,environmental law and policy,sacred natural sites,sustainable practices,traditional knowledge,farmers,cattle keepers
Towards Radically Innovative Materials for Better and Sustainable Organic Solar Cells (TRIBOSC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-12-16
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Organic compounds could provide a sustainable revolution in the generation of electricity from sunlight. Organic photonic material nanostructures, capable of efficient light harvesting when employed as active layer in solution processable organic solar cells and photovoltaic devices are essential. The present proposal demonstrate an innovative strategy for the direct application of conceptually new, chiral donor-acceptor (D-A) materials in organic solar cells (OSCs). Taking a leaf from nature’s book, we envision that introduction of chiral functionalities in the active layer could administer anisotropic charge transport with excellent charge carrier mobilities, precise molecular ordering with nanoscopic D-A domains and re-enforced intra/inter molecular communication. The proposal brings together an experienced researcher with expertise in the area of design and synthesis of D-A supramolecular conjugates and ultrafast time resolved spectroscopy with an internationally recognized host laboratory in the University of Nottingham, UK with an expertise in the synthesis of chiral superstructures for organic materials and developing photovoltaic device fabrication. It is our strong conviction that the novel approach depicted here, will instigate new breakthroughs for the construction of novel photofunctional materials with enhanced solar cell efficiencies. As the proposal integrates skill sets from extended network of collaborators such as chemists, engineers and physicist with diverse backgrounds, and we believe that it will eventually enhance and contribute towards European excellence in sustainable solar light harvesting.

Keywords: bulk heterojunction solar cells,light harvesting,sustainable chemistry,supramolecular material chemistry,organic photovoltaics,charge separated states,chiral donor acceptor molecules,optoelectr
Exhaustion-resistant CAR-T cells for the treatment of solid tumours (Exh-Res-CART)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Adoptive transfer of T-cells collected from patient’s blood and engineered to express chimeric antigen receptors (CARs) has produced unprecedented clinical responses in patients with cancer. CAR-T cells targeting CD19 were recently approved by the US food and drug administration (FDA) and the European Commission (EC) for the treatment of leukemia and lymphoma, heralding a new era for cancer treatment. However, despite the stunning results of CAR-T cells in patients with hematologic malignancies, results with CAR-T cells in patients with solid tumors are far from expected. Although CAR-T cells are able to infiltrate solid tumors and exert antigen directed activity, observed responses in patients with solid tumors have been minor and transient. But what are the mechanisms behind the poor T-cell activity in solid tumors? Are CAR-T cells susceptible to dysfunction in a similar way as the endogenous tumor-specific T cells that fail to eliminate the tumors in treatment-naïve cancer patients? My central hypothesis is that CAR-T cells become exhausted in the tumor microenvironment mainly due to continuous antigen encounter, and that this process can be prevented or delayed. My general aim for this project is to enhance the persistence and function of CAR-T cells by overcoming T-cell dysfunction while promoting T-cell stemness. By using animal models and a combination of innovative technologies, including next-generation sequencing and genome editing I will: 1) elucidate the T-cell intrinsic mechanisms by which CAR-T cells become unresponsive to solid tumors, 2) design new approaches to enable infused T cells to overcome dysfunction and persist within the tumor microenvironment.

Keywords: chimeric antigen receptors,solid tumors,t cell dysfunction
SCALING UP OF THE MEDUNIVERSE PATIENT CASE ENGAGEMENT PLATFORM (MEDUNIVERSE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Every interaction with healthcare professionals (HCPs) presents the Life Sciences (LSci) industry with opportunities to deliver and derive value. However, the low level of digital maturity prevalent in the sector means that often these opportunities don’t materialise. The manner in which new treatments are communicated and how feedback regarding these is gathered is a clear example of this problem. Current approaches fail to engage HCPs and to gather data in a systematic manner. With this problem in mind, we developed MedUniverse - a patient case engagement platform that helps the LSci industry communicate with HCPs in an engaging manner which captures relevant quantitative data and delivers reliable results. In the platform, HCPs interact with simulated patient cases, gaining feedback on their responses and viewing how their understanding compares to their peers. The interaction data is then presented in a dashboard for our customers to gain insights into the effectiveness of their medical education and multi-channel marketing campaigns.
Deaf life narratives in times of transition. (DEALS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-11-01
End date: 2017-10-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The research project concerns deaf people who use a signed language, such as BSL (British Sign Language). It investigates the potential of a culturally familiar practice, storytelling, as a means of promoting agency, resilience and better well being. Using techniques of narrative therapy, narrative analysis and grounded theory, the project will explore the significance of life story work to enhance well being from a cross cultural perspective, engaging with deaf migrants from diverse nation states. It will result in a life story instrument, piloted during the study that exploits the visual learning strengths of deaf people and the properties of visual (non-textual) languages through digital media. It extends current research on narrative methods as a form of cultural brokering and emancipatory methodologies within critical deaf epistemologies.

Keywords: signed languages deaf peoples
Developing healthy crops for EU: T3SS-Recognition EXploration (T-REX) for plant immunity against bacteria (T-REX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-14
End date: 2021-01-13
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Among the greatest challenges of the 21st century are bacterial diseases that permanently threat plants and animals, including humans to whom they often are lethal. In plant and animal production, bacteria can cause severe yield reductions if not effectively controlled. However, the current control measures include use of environmentally problematic antibiotics, which in addition may lead to appearance of bacterial strains resistant to these antibiotics. Recent progress in the host laboratory using a Genome Wide Association Study (GWAS) of wheat reveals a hitherto unknown recognition mechanism of the effector translocator widely conserved in pathogenic bacteria. The associated receptor complex is predicted to have wide potential for exploitation in bacterial disease control, not only in crop plants but also in livestock production. In the T-REX project, number of parallel efforts will be taken to characterize the recognized T3SS component, the membrane bound receptor complex and the activated immunity. This will be undertaken using an integrated approach, which involves my background knowledge and experiences combined with the ones of the host institution within molecular genetics, biochemistry, molecular biology and bioinformatics. This study will shed light on the role of T3SS as a PAMP, which will help us to elucidate the complex plant-bacterial interactions and can potentially lead to the development of new phyto-pathogen control strategies. T3SS being conserved among plant and animal pathogen, the outcome of the T-REX project has potential for extrapolation into animal pathological systems, including humans, and may contribute to the world of medicine.

Keywords: bacteria,t3ss,plant defense,wheat
Intersectional Analyses of Welfare Chauvinism in Europe (INWELCHAV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-01
End date: 2019-07-31
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

In the European context of ongoing crises (economical, political and humanitarian), populist radical right parties have consolidated their presence in mainstream politics. These parties sharpened the debate concerning the future of the welfare state, arguing for a separation between the “natives” of the ethnic majority, as self-evident targets for full welfare provision, and those belonging to a generic “other”–wherein migrants, ethnic minorities, racialized groups, people with alternative lifestyles are lumped together. However, both studies of the populist radical right and welfare studies are missing an intersectional awareness to how such conceptual distinction is operated. Taking a decidedly interdisciplinary approach, the present project aims to explore and scrutinize in a comparative framework the populist radical right’s discursive (re)construction of cultural identities and the terms of national belonging at times of economic, political and societal crises across Europe, from an intersectional perspective. The project will combine political sociology, with a focus on welfare and populism studies, intersectionality, and critical discourse analysis. The project focuses on three cases: the Finns Party (PS/SF) in Finland, the Greater Romania Party (PRM) in Romania, and the Sweden Democrats in Sweden. The objectives are to provide an account of the communalities and differences in articulating national identity and welfare chauvinism in the chosen countries, and to map out how these are expressed within the common European institutional framework, namely in the European Parliament.

Keywords: intersectionality,populist radical right,welfare chauvinism,european union,finland,romania,sweden,political sociology
KAM and Innovation services for SMEs in Lombardia and Emilia-Romagna (KAMINLER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Italy,Italy,Italy
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 400877.75
EU funding (EUR): 400793.0
Participants: 13
Project status: CLOSED

The objective of KAMINLER is the delivery of a specific Enterprise Europe Network service designed to enhance the innovation management capacity of SMEs in Lombardy and in Emilia-Romagna, by providing in-depth support in the areas where these services are absent or unaffordable on local markets. EEN partners in the two regions will deliver Key Account Management services to the beneficiaries of the SME Instrument of Horizon 2020, dealing with coaching assignments and addressing specific innovation weaknesses and will support particularly promising SMEs to improve their capacity to manage innovation processes.

Keywords: innovation,sme instrument,coaching,fet open,fast track to innovation
Disease defence in groups: the role of relatedness, risk and pathogen type (diseaseINgroups)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Croatia
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2025-08-26
Duration (months): 24.0
Total project cost (EUR): 159463.68
EU funding (EUR): 159463.68
Participants: 1
Project status: SIGNED

The ongoing COVID-19 pandemic demonstrates the drawbacks of living socially; increased contact and high host density encourage the spread of disease in social groups, compared to those living solitary. Social interactions promote disease spread, but how do animal groups deal with the increased risk of epidemics? The goal of this proposal is to identify key factors governing disease management in groups, so as to enhance our understanding of how behavioural host defences and immunity evolve. In turn, this will help shed light on how group disease defences influence social evolution. This work is crucial as the importance of pathogens as a driver of social complexity and novel adaptations is still unclear. To achieve this goal, I will use a powerful genetically and genomically established insect model organism, the flour beetle (Tribolium castaneum), to manipulate group relatedness, size and structure, as well as epidemiological risk (pathogen species and infection stage). I will then explore how these factors influence group cohesion or dissolution. By using a combination of chemical analyses to identify disease cues and recognition profiles of healthy group members during a secondment, and bioinformatic approaches at my host institution, this project will also provide a detailed picture of the underlying olfactory circuits and genetic pathways behind disease management in groups. By combining behavioural, chemical and bioinformatic assays, this project will be able to address key gaps in our knowledge of group disease defence and will have a large impact on the fields of social evolution and behaviour. The transfer of knowledge at both institutions will significantly expand my technical skillset and allow me to development of my own, independent research niche. The data acquired and skills learnt during this project will be invaluable for applying for independent research positions after the fellowship.

Keywords: group disease defences,animal behaviour,disease chemoreception,chemical ecology,evolution of social immunity