Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Human Platelet Lysates-based Scaffolds for Interfacial Multi-tissue Repair (InterLynk)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Netherlands,Netherlands,Portugal,Portugal
Call: Biological scaffolds for tissue regeneration and repair (RIA) (H2020-NMBP-TR-IND-2020-twostage, 2020)
Start date: 2021-01-01
End date: 2025-01-31
Duration (months): 49.0
Total project cost (EUR): 5999638.79
EU funding (EUR): 5999638.0
Participants: 8
Project status: SIGNED

InterLynk aims to develop multi-tissue 3D patient-specific scaffolds by providing a portfolio of highly compatible and biofunctional composite inks and biomaterials, and streamlining their co-processing using an upgraded AM equipment. Unprecedented biofunctionality in the synthetic reconstruction of complex interfacial tissues is expected to be obtained. A double network photocrosslinkable biomaterial system based on human plasma-derived Platelet Lysates (PL) will be used as base matrix. The PL-based hydrogels will be further combined with mechanically reinforcing biomaterials, namely CaP-based bioceramics and PCL-LA polymers, to produce bone-like and fibrous structures, respectively, and will be able to be blended with natural drug carriers (flavonoid-loaded nanomicelles). Compositional and structural variations will be enabled by combining photo-assisted printing and MEW/ESP in a single-step hybrid AM process. New computational tools will support the mechanobiological optimization of all biomaterials and final parts, as well as the AM process design. Superior biofunctionality of the InterLynk’ scaffolds will be validated in an highly complex multi-tissue interfacial biosystem, the temporomandibular joint. InterLynk will implement comprehensive strategies to engage key groups of stakeholders (clinical, engineering, regulatory and market-related) in the development of biological scaffolds, establishing a truly multidisciplinary co-creation process. These scaffolds are expected to have no counterpart in both fabrication and multi-tissue regeneration, avoiding time-consuming and costly procedures in both dimensions. This will increase current AM (bio)fabrication capabilities and application range, widely extending its use. Their high flexibility and unique performance will considerably reduce immune rejection, risk of contamination and, inherently, rehabilitation time of multi-tissue injuries resulting in increasing wellbeing and healthcare costs reduction.

Keywords: autologous biomaterials,human platelet lysates,photosensitive biomaterials,additive manufacturing,3d printing,electrospinning,interface tissue engineering,multimaterial biological scaffolds
City Platform as a Service - Integrated and Open (CPaaS.io)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Switzerland,Netherlands,United Kingdom,United Kingdom
Call: IoT/Cloud/Big Data platforms in social application contexts (H2020-EUJ-2016-1, 2016)
Start date: 2016-07-01
End date: 2018-12-31
Duration (months): 30.0
Total project cost (EUR): 1786407.5
EU funding (EUR): 1326407.5
Participants: 7
Project status: CLOSED

Data has been termed to be the „oil of the 21st century“. Data will also be what the smart city of the future runs on. To make this a reality, cities need a platform where data from a variety of sources – IoT and sensor data, open government data, social media, and other 3rd party data providers – can be processed, linked, and analysed in order to extract valuable information that in turn can also be provided as linked open data, and with which new types of services are created and provisioned. Both cities as well as private service providers can build novel applications and services on top of this platform; the platform thus becomes an economically valuable driver for Smart City Innovation. The main goal of this project is to develop such a City Platform as a Service (CPaaS) that can be federated to support regional or even global applications, and that forms the basis for a smart city data infrastructure. Technical challenges that need to be addressed include data provenance, data quality, adaptive privacy levels, policies and adaptive processes for distributing and deploying processing intelligence to the cloud or to the edge. Other important aspects include data governance, data management and the empowerment of the citizen to control access and sharing of data about her using a MyData approach. In addition to the development of the platform, several use cases in the domains of event and transport management, water management, and health emergency services will be implemented and validated with cities in Europe and Japan. Blue prints – both from a technical as well as from a process perspective – for these domains that can easily be transferred and adapted from one region to another will be developed. This will for example allow transferring the learnings from the Asian Winter Games 2017 to the Tokyo Olympics 2020. And finally, the results from the project are used to develop standardisation proposals in the related areas to ensure impact beyond the project.

Keywords: big data,linked data,open government data,cloud,smart city
SWITLER:Small WInd Turbine Lightwight Efficient generatorR (SWITLER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Israel
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Wind energy is an attractive solution for the energy demands of remote installations. It could provide energy to remote Base Station Sites, which account for up to 50% of the total operational costs in the Telecommunication Industry. It is also a feasible source of energy in the agricultural sector. Farms spend around €50.000/year in power supply due to their remote location with respect to power plants. Installation of Small Wind Turbines (SWT) that allow energy harvesting on-site will produce operational cost savings of €32.000/year. However, large purchase costs and long return of investment (25-30 years) are strong barriers for wind power implementation. Responding to these market needs, at EVR Motors we have invested so far €1.000.000 of private capital to develop a novel direct drive generator: SWITLER. Using a lean philosophy design and eliminating non-desirable features we achieve a manufacturing cost reduction of up to 60%. Reducing magnet mass materials in 20% and eliminating iron from the rotor, we reduce the generator weight by up to 70% when compared to current solutions in the market. Furthermore, efficiency is increased in as much as 96%. Our generator removes the need of a transformer, which enables the use of SWT applications off-grid in remote areas. This already patented (approval in process) technology will revolutionize the Small Wind Turbine manufacturer’s value of chain. Our objective is to start SWITLER commercialization by 2017 introducing it in the SWT market. This market is expected to increase massively from €768 million in 2013 to €2.517 million by 2020, at a Compound Annual Growth Rate (CAGR) of 22%. Our market strategy will focus on Israel for the first two years. We will then percolate the European market through UK, which accounts for 13% of the global market. After the 6 initial commercialization years, SWITLER sales are forecasted to accumulate €25.728.000 revenues.

Keywords: small wind turbine swt,direct drive generator,europe,wind energy,renewable energy,carbon systems
NovEl Strategies for treatIng tendon-to-bone injurieS - kiNESIS (kiNESIS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-04-01
End date: 2018-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Body movement requires efficient transfer of force from contracting muscles to bone. Damage to the tendinous insertions is the 8th leading cause of disease burden and is the largest single cause of work loss in Europe. Historically, approaches for improving healing in these attachment units have focused on modifying repair techniques and rehabilitation protocols. These methods are proven to be very ineffective, since failure rates of as high as 94% are often reported. We have discovered that two distinct pools of progenitor cells form the tendon-to-bone attachment unit, known as “enthesis”. Moreover, we showed that these two pools are regulated separately via certain signalling pathways. These recent, yet exciting, findings gave rise to the novel idea that we can use these progenitors to regenerate the unique attachment unit, with the help also of the identified signalling pathways. The overall goal of our ERC PoC project is to take the first steps towards the development and pre-commercialisation of novel regenerative strategies for enhanced tendon-to-bone healing in the adult setting. Specifically, (1) the first target is to establish the technical feasibility of our idea by performing a series of in-vitro and in-vivo-experiments, the latter utilising a novel state-of-the-art rotator cuff enthesis injury model that we developed. If the results of our preclinical studies are successful, they will have a direct impact on future regenerative strategies for tendon-to-bone repair. (2) The second target of the kiNESIS project is to establish the commercialisation potential of our idea. The commercialisation can result in a truly revolutionising, simple and non-invasive needle-based therapy for tendon injuries.

Keywords: musculoskeletal conditions,enthesis regeneration,tendon to bone injuries,pre commercialization,development
Deep Biosignatures on Mars and Earth (D BIOME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-10-04
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

In recent decades, samples from mines and boreholes have revealed that our planet’s biosphere extends several miles downwards into the crust. Pores and fissures far below the seafloor and land surface are populated by vast numbers of microorganisms, with broad economic and scientific implications. These implications reach as far as Mars, whose subsurface has provided a potentially habitable environment for billions of years, protected from the hostile conditions at the surface. Although Earth's modern-day "deep biosphere" is now the subject of a major global research effort, almost nothing is known about its variation across geological time, which may have been considerable and highly consequential for planetary biogeochemistry. This project will combine state-of-the-art analyses of fossil and chemical traces of deep life ("deep biosignatures") with experimental and modelling work to elucidate the abundance, activity and geological record of ancient subsurface life on Earth and its possible relevance for Mars. Dr McMahon’s research at the UK Centre for Astrobiology (School of Physics and Astronomy, University of Edinburgh) will be directed towards four main objectives, as follows: 1. To identify and describe ancient deep biosignatures in both marine and terrestrial rocks on Earth, showing how their deep origin can be confirmed, and extending the deep fossil record. 2. To conduct experiments to determine whether and how, if they exist, deep biosignatures could be detected in rocks on Mars by rover instruments—particularly those on the European ExoMars rover. 3. To simulate experimentally the conditions deep below the surface of Earth and Mars and discover which environmental parameters most strongly affect the growth of relevant deep microorganisms and the production of biosignatures. 4. To model how the deep biosphere has changed in size and activity over the history of the Earth, and how a deep biosphere on Mars, if it ever existed, could have done so.

Keywords: mars,astrobiology,habitability,exomars,fossils,biosignatures,deep biosphere
Unravelling neuronal heterogeneity in energy homeostasis regulation (ARC-NeuroHet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

This MSCA Reintegration proposal is aimed to study the heterogeneity of neuronal populations implicated in the maintenance of energy balance. Because of their location, neurons in the arcuate nucleus of the hypothalamus (ARC) integrate nutrient and hormonal signals carried in the blood. Then, they regulate downstream neuron’s activity in order to adapt food intake and energy expenditure. Deregulation of energy homeostasis can lead to obesity and diabetes, two of the major chronic diseases in the EU. AgRP neurons, an ARC population, have a prominent role in the regulation of food intake and systemic insulin sensitivity. They establish axonal projections with several brain areas and recent evidences show that each sub-circuit can have a specific function in the regulation of food intake and/or glucose homeostasis. For this fellowship I propose to use an innovative experimental approach to investigate a specific novel AgRP neuronal subpopulation, characterized by the expression of the UDP-receptor, P2Y6, as a first step to unravel the heterogeneity of the total population. Although P2Y6 activation increases short-term food intake, its effects on glucose homeostasis are still unknown. I plan to combine new recombinase technologies with state of the art techniques to genetically identify the AgRP, P2Y6 subpopulation and then: 1) characterize their in vivo dynamic response to physiological activators; 2) map specific AgRP+, P2Y6+ sub-circuits and dissect their role in each facet of energy homeostasis; and 3) investigate new molecular markers, as possible drugable targets. Results from this project will unveil new aspects of neuronal heterogeneity that participate in the regulation of energy homeostasis and will contribute to design new strategies to curb the actual obesity trends. The completion of this MSCA fellowship represents an exceptional opportunity to reinforce my professional maturity and to develop my independent research line.

Keywords: agrp neurons,neuronal heterogeneity,energy homeostasis,obesity,p2y6
HADES - Optical Hot Air Leak DEtection System (HADES)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany
Call: Optical hot air leak detection system proof-of-concept development (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2020-12-31
Duration (months): 34.0
Total project cost (EUR): 570000.0
EU funding (EUR): 399000.0
Participants: 1
Project status: CLOSED

Light carbon structures are increasingly used in modern aircrafts for reducing weight and thus fuel consumption. The carbon materials are more sensitive to overheating than metals. Hot air ducts are used to conduct air heated by engine exhaust to the cabin heating system. At several locations, those hot air ducts are installed within or in close proximity to the carbon structures. Therefore, reliable and precise hot air leak detection is an essential safety feature of modern aircrafts. The proposed activity aims at developing an innovative, powerful and reliable fibre-optic technology for an aircraft hot air leak detection system and validating it in a representative aircraft environment. State-of-the-art electrical hot air leak detection systems detect and localize leaks in aircraft hot air ducts by analyzing electric shortcuts. However, the response of such systems just indicates that the critical temperature is exceeded. It is impossible to vary the threshold setting along the cable and false alarms due to stray signals are common. Localization of leaks is difficult and the sensor cables are irreversibly damaged by exceeding the critical temperature. Based on our deep understanding of using fibre-optic sensing systems in harsh and safety-critical environments, LIOS will select the optimum fibre-optic technology for hot air leak detection in aircrafts, which overcomes the limitations of the electrical systems, complies with the requirements of the tender and fulfils the other essential requirements of aircraft applications. LIOS will demonstrate the technology’s capabilities, using a proof-of-concept system in the LIOS laboratories. After testing, we will re-design the demonstrator to enable a demonstration within an aircraft environment, allowing to pass the respective environmental tests and to fulfil the requested TRL of 6. The re-designed demonstrator will be installed at the facilities of the topic manager and tested in collaboration with the topic manager.

Keywords: hot air leak detection fibre optic raman brillouin rayleigh scattering fbg
Photoredox catalysis as a tool for the site-specific labelling of proteins (PhotoChemBio)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 189099.84
EU funding (EUR): 189099.84
Participants: 2
Project status: CLOSED

Photoredox catalysis (the use of visible-light to accelerate chemical reactions) has emerged as a uniquely valuable platform in organic chemistry, facilitating the use of native functionality to construct new C–C bonds. The key aim of this research is the unification of photoredox catalysis and bioconjugation to specifically target 3-nitrotyrosine (3NT) – a critical biomarker for the diagnosis of several diseases including Alzheimer's, heart disease, and stroke, in order to facilitate the rapid identification and mapping of this important residue within the proteome. Current chemical strategies to functionalize 3NT residues are hampered by harsh chemical conditions and poor site-selectivity; therefore, the development of a novel platform based upon the use of visible-light will have far-reaching implications in terms of identifying early-stages of disease and the development of new therapeutic strategies.

Keywords: bioconjugation,photoredox catalysis,immunooncology
Fast, Accurate, Low Cost and Hand Held NIR Technology to Ascertain Wood Origin and Quality during Logistic Operations (NIRWOOD)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-08-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Roundwood production in the EU-28 reach 425 million m³ (Eurostat 2013), which make Europe the largest producer within the G20. In addition to this internal production, Europe imports 4.8 billion € of timber and other wood products from outside the EU. All this raw material has to be transported. Logistics operations and its traceability assurance are a mayor point of weakness for the European Woodworking companies because, once the timber is harvested and loaded, only experts can differentiate some species from other while its origin can only be stablished with complex laboratory analysis. This implies two mayor challenges: fakes and illegal logging, which cannot be solved with current available solutions and cause penalties, claims, bad image or even the immediate suspension of authorization to trade. GEAFORESTAL is a Spanish Company operating on the Consultancy forestry sector specialised in engineering and natural environment. We are experts on sustainability, wood traceability certification Systems and international timber trade and we will overcome these challenges putting in the market NIRWOOD: the first commercial system based in Near-infrared Technology (NIR) to identify timber species quality and its origin. NIRWOOD can be used by producers (pre-delivery checks) and customers (reception control) and by Authorities in their control function. Our objectibe is to be the first company to put in the market a simple, accurate, fast, global and cheap solution to identify roundwood and sawnwood.

Keywords: transport,logistics,wood,eutr