Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecular bases of kinetochore-microtubule attachment and their implications for cell cycle control. (KINCON)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Molecular and Structural Biology and Biochemistry
Countries involved: Germany,Italy
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-03-01
End date: 2014-09-30
Duration (months): 67.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 2
Project status: CLOSED

Equal partition of the genetic material to the daughter cells in mitosis requires the accurate anchorage of the mother cell s chromosomes to spindle microtubules. This process takes place at kinetochores, complex scaffolds containing ~100 different proteins. Conceptually, kinetochores can be viewed as performing four distinct but highly integrated functions: 1) they bind centromeric chromatin at a specialized protein-DNA interface; 2) they build a dynamic microtubule-binding interface that is tightly linked to the centromere-binding interface; 3) they correct erroneous microtubule attachments; 4) they synchronize the progression of the cell cycle oscillator with the progression of the microtubule-kinetochore attachment process. In mammals, all four functions are essential, and their abrogation has untenable consequences for normal cell life. Conversely, their partial impairment has been implicated in chromosome instability and in the development of cancer and an array of genetic diseases. Our goal is to be able to map the kinetochore functions schematized above to the as yet largely uncharacterized architecture of the kinetochore and to unravel the elements of feedback control that allow their integration. By using a combination of structural and functional methods, we have made several recent important contributions to the field of kinetochore biology. In this application, we propose to take our efforts to a new level of complexity that will allow us to gain an integrated view of how kinetochores bind microtubules, how they correct improper attachment, and how they coordinate microtubule attachment with cell cycle progression. Our approach rests on strong experience in biochemical reconstitution and structural analysis, and is complemented by the introduction of methods to assess and model the dynamic responses of kinetochores to their variable environment.

Keywords: kinetochores,aneuploidy,cancer,single-molecule
Molecular Basis of Neuronal Ageing (NEURONAGE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: ERC Advanced Grant Interdisciplinary Panel
Countries involved: Greece
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-05-01
End date: 2015-04-30
Duration (months): 72.0
Total project cost (EUR): 2376000.0
EU funding (EUR): 2376000.0
Participants: 1
Project status: CLOSED

Ageing is associated with marked decrease of neuronal function and increased susceptibility to neurodegeneration, in organisms as diverse as the lowly worm Caenorhabditis elegans and humans. Although, age-related deterioration of the nervous system is a universal phenomenon, its cellular and molecular underpinnings remain obscure. What mechanisms are responsible for the detrimental effects of ageing on neuronal function? The aim of the proposed research programme is to address this fundamental problem. We will implement an interdisciplinary approach, combining the power of C. elegans, a highly malleable genetic model which offers a precisely defined nervous system, with state-of-the-art microfluidics and optical imaging technologies, to manipulate and monitor neuronal activity during ageing, in vivo. Our objectives are four-fold. First, develop a microfluidics platform for high-throughput manipulation and imaging of specific neurons in individual animals, in vivo. Second, use the platform to monitor neuronal function during ageing in isogenic populations of wild type animals, long-lived mutants and animals under caloric restriction, a condition known to extend lifespan from yeast to primates. Third, examine how ageing modulates susceptibility to neuronal damage in nematode models of human neurodegenerative disorders. Fourth, conduct both forward and reverse genetic screens for modifiers of resistance to ageing-inflicted neuronal function decline. We will seek to identify and thoroughly characterize genes and molecular pathways involved in neuron deterioration during ageing. Ultimately, we will investigate the functional conservation of key isolated factors in more complex ageing models such as Drosophila and the mouse. Together, these studies will lead to an unprecedented understanding of age-related breakdown of neuronal function and will provide critical insights with broad relevance to human health and quality of life.

Keywords: caenorhabditis elegans,microfluidics,optical imaging of neuronal activity,microelectromechanical systems,behavioral plasticity
From flies to humans combining whole genome screens and tissue specific gene targeting to identify novel pathways involved in cancer and metastases (COMBINE)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Physiology, Pathophysiology and Endocrinology
Countries involved: Austria
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-01-01
End date: 2013-12-31
Duration (months): 60.0
Total project cost (EUR): 2499465.0
EU funding (EUR): 2499465.0
Participants: 1
Project status: CLOSED

Cancer care will be revolutionized over the next decade by the introduction of novel therapeutics that target the underlying molecular mechanisms of the disease. With the advent of human genetics, a plethora of genes have been correlated with human diseases such as cancer the SNP maps. Since the sequences are now available, the next big challenge is to determine the function of these genes in the context of the entire organism. Genetic animal models have proven to be extremely valuable to elucidate the essential functions of genes in normal physiology and the pathogenesis of disease. Using gene-targeted mice we have previously identified RANKL as a master gene of bone loss in arthritis, osteoporosis, and cancer cell migration and metastases and genes that control heart and kidney function; wound healing; diabetes; or lung injury Our primary goal is to use functional genomics in Drosophila and mice to understand cell transformation, invasion, and cancer metastases of epithelial tumors. The following projects are proposed: 1. Role of the key osteoclast differentiation factors RANKL-RANK and its downstream signalling cascade in the development of breast and prostate cancer. 2. Requirement of osteoclasts for bone metastases and stem cell niches using a new RANKfloxed allele; function of RANKL-RANK in local tumor cell invasion. 3. Role of RANKL-RANK in the central fever response to understand potential implications of future RANKL-RANK directed therapies. 4. Integration of gene targeting in mice with state-of-the art technologies in fly genetics; use of whole genome tissue-specific in vivo RNAi Drosophila libraries to identify essential and novel pathways for cancer pathogenesis using whole genome screens. 5. Role of TSPAN6, as a candidate lung metastasis gene. Identification of new cancer disease genes will allow us to design novel strategies for cancer treatment and will have ultimately impact on the basic understanding of cancer, metastases, and human health.

Keywords: rankl-rank,breast cancer,prostate cancer,metastasis,whole genome drosophila genetics,fever,osteoclast,signal transduction,mammary gland biology
Communicating NANOtechnology to European YOUth (NANOYOU)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Coordination and support actions
Countries involved: Israel,United Kingdom,Denmark,Spain,Austria,France,France,Belgium
Call:  (FP7-NMP-2008-CSA-2, 2008)
Start date: 2009-04-01
End date: 2011-06-30
Duration (months): 27.0
Total project cost (EUR): 1655014.0
EU funding (EUR): 1453449.0
Participants: 9
Project status: CLOSED

NANOYOU will design and undertake a communication and outreach program in nanotechnology (NT) aimed at European youth. The project will reach 11-18 year olds through school programs to take place in at least 20 EU Member States and Associated States. Additional programs aimed at young adults aged 19-25 will be offered in science centres. The school programs are planned to involve at least 400 schools and reach more than 25,000 students. The science centres program is expected to reach an initial 4,000 young adults during NANOYOU and many more subsequently as more science centres adopt the program. Recent surveys show that most European citizens have poor understanding of NT, its potential and risks. This needs to be rectified if the European public is to contribute positively to future decision-making about the use of NT. In focusing on ages 11-25, NANOYOU recognizes that effective programming needs to be tailored to the educational capabilities and interests of the target population. Programming specialization will be provided for subgroups within this youth population. While some FP6 programs have made an excellent start in informing the public about NT, they have not focused on youth nor have their activities taken places in the schools. NANOYOU will combine temporary exhibitions, innovative computer games, experiments and other online content, with workshops aimed at promoting dialogue that will raise participants&apos; awareness of ethical, legal and societal aspects of NT. NANOYOU&apos;s content will be balanced and up-to-date, and teacher training materials will be prepared to equip science teachers and other personnel to present the NANOYOU programs. NANOYOU has assembled a strong consortium with partners experienced in nanotechnology, educational methodology and science communication, as well as organizations highly suited and experienced at arranging outreach/communication activities in schools and science centres

Keywords: nanotechnology,outreach,communication,dialogue,youth,children
Supporting EU’s Freight Transport Logistics Action Plan on Green Corridors Issues (SUPERGREEN)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Sustainable surface transport (INCLUDING THE �EUROPEAN GREEN CARS INITIATIVE�)
Action type: Coordination and support actions
Countries involved: Greece,Norway,Italy,Spain,Austria,United Kingdom,Finland,Belgium,United Kingdom,Germany,Türkiye,Spain,Portugal,Italy,Ukraine,Germany
Call:  (FP7-SST-2008-TREN-1, 2008)
Start date: 2010-01-15
End date: 2013-01-14
Duration (months): 36.0
Total project cost (EUR): 3453746.71
EU funding (EUR): 2634698.0
Participants: 23
Project status: CLOSED

The purpose of “SuperGreen” is to promote the development of European freight logistics in an environmentally friendly manner. Environmental factors play an increasing role in all transport modes, and holistic approaches are needed to identify ‘win-win’ solutions. “SuperGreen” will evaluate a series of “green corridors” covering some representative regions and main transport routes throughout Europe. • The selected corridors will be benchmarked based on parameters and key performance indicators covering all aspects related to transport operations and infrastructure. Environmental issues and emissions, external-, infrastructure- and internal costs will be covered to get an overall and realistic picture. Based on this benchmarking, areas and candidates for improvement will be identified (i.e. bottlenecks). • The next step will be to evaluate how “green technologies” may support improving the identified bottlenecks. Among the green technologies considered may be novel propulsion systems, alternative fuels, cargo handling technologies, new terminal technologies or novel concepts relevant for the multimodal “green corridors”. The benchmarking issue is an iterative process. • Next, a similar process needs to be accomplished taking into consideration “smarter” utilisation of available information in the multimodal chain (ICT-flows). An analysis will be made on how this information can be utilised to achieve “greener” logistics along the “green corridors” (e.g. e-freight, Supply Chain Management (SCM), smarter planning, scheduling and tracking & tracing). • Based on these iterative benchmarks and evaluations, new R&D within specific topics may be needed to improve the identified bottlenecks. Recommendations for future calls for R&D proposals will be made. • Last but not least, the project will review and assess the implications of alternative policy measures for green corridors, both at the local and the European level.

Keywords: transport corridors,logistics,sustainability,benchmarking,environment
Road safety Data Collection, Transfer and Analysis (DACOTA)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Sustainable surface transport (INCLUDING THE �EUROPEAN GREEN CARS INITIATIVE�)
Action type: Collaborative project
Countries involved: United Kingdom,Belgium,France,France,Greece,Netherlands,Sweden,Italy,Belgium,Austria,Poland,United Kingdom,Germany,Germany,Israel,Spain,Germany,Germany
Call:  (FP7-SST-2008-TREN-1, 2008)
Start date: 2010-01-01
End date: 2012-12-31
Duration (months): 36.0
Total project cost (EUR): 7310655.22
EU funding (EUR): 5500012.0
Participants: 18
Project status: CLOSED

Evidenced based approaches lie at the heart of the most successful road safety polices and accident and other road safety data is a key component. No single set of data can support all road safety questions and the European Road Safety Observatory has been developed as a focus for a range of data and information types. One part of the Observatory includes a series of data protocols and collection methodologies for a range of data types including national level and in-depth accident data, exposure data and safety performance indicators. Although it is a substantial step forward the ERSO remains the first stage and further development is needed. This proposal addresses the needs for further improvement of the Observatory by enhancing, structuring and applying the data and information it contains. DaCoTA WP3 aims to continue the efforts made in previous projects by gathering, consolidating and standardizing the available road safety data and information, through the exploitation of all available sources, in a systematic and comprehensive way. New data on road safety management processes will be gathered from a selection of key EU Member States together with data concerning exposure and indicators. This will be assembled and structured using, for example, the approaches developed within the Sunflower project. DaCoTA will identify, train and further support new teams across the Member States to conduct detailed accident investigations for safety purposes. It will develop new approaches to evaluate the casualty reduction effectiveness of new technologies and will develop new innovative approaches to gather routine data on normal driving behaviour. Key factors of the proposal include a highly skilled and experienced team to develop the safety information resources, the involvement of industry stakeholders as partners within the project and the close liaison with Member States through enhanced national experts groups.

Keywords: accident,road safety,data,information,policy,risk,exposure,in-depth,naturalistic driving
Public Transportation - Accessibility for All (PUBTRANS4ALL)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Sustainable surface transport (INCLUDING THE �EUROPEAN GREEN CARS INITIATIVE�)
Action type: Collaborative project
Countries involved: Austria,Serbia,Switzerland,Germany,Germany,Bulgaria,Hungary,Germany,Slovenia
Call:  (FP7-SST-2008-RTD-1, 2008)
Start date: 2009-09-01
End date: 2012-11-30
Duration (months): 39.0
Total project cost (EUR): 2861816.16
EU funding (EUR): 1807662.0
Participants: 14
Project status: CLOSED

Pubtrans4all will develop a prototype vehicle-based boarding assistance system that can be built into new rail vehicles or retrofitted into existing rail vehicles to improve accessibility for all persons. Accessibility for rail vehicles is particularly problematic since rail vehicles have a long service life and so many currently inaccessible vehicles will remain in service well into the future. PubTrans4all will help make existing public transport systems more accessible, improving service for everyone. The PubTrans4all project’s objective is to develop a standard boarding assistance system that can be used on many different types of rolling stock and infrastructures. The boarding assistance system will not simply be a device, but rather include contributing elements that make it possible to effectively use the device to access rail vehicles. The prototype will be developed by a multi-disciplinary consortium including users, public transport operators, academic researchers and manufacturers. As part of the process of developing the prototype boarding assistance system, the project will survey state of the art accessibility devices and make recommendations for best practices in the use and operation of these existing devices. The project will include an extensive dissemination program designed to communicate study results widely, but also to help inform the general public and decision-makers about the importance and challenges in providing accessibility for all. The PubTrans4all project will be completed by a well balanced and geographically diverse consortium. Especially beneficial is the participation of several Eastern European partners – since accessibility is not sufficiently recognized as a problem in many of these countries. Accessibility for all is critical to creating an equitable, effective and efficient transport system. The project PubTrans4all will help build a fully accessible rail network.

Keywords: accessibility,public transport,urban transport,vehicle entrance
Marine INspection rObotic Assistant System (MINOAS)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Sustainable surface transport (INCLUDING THE �EUROPEAN GREEN CARS INITIATIVE�)
Action type: Collaborative project
Countries involved: Italy,Germany,Italy,Greece,Spain,United Kingdom,Bulgaria,Greece
Call:  (FP7-SST-2008-RTD-1, 2008)
Start date: 2009-06-01
End date: 2012-06-30
Duration (months): 37.0
Total project cost (EUR): 2958170.6
EU funding (EUR): 2102035.0
Participants: 10
Project status: CLOSED

The increasing competitiveness in marine operations creates a need for new system concepts that introduce high technology value added products, facilitate the processes involved and minimize the downtimes. The need, thus, lies not only in incorporating the technological means so far available, but in changing the way the corresponding authorities stand against the challenges at hand. MINOAS project proposes reengineering of the overall vessel-inspection methodology, by introducing an innovative system concept that incorporates state of the art technologies, but at the same time formulating a new standardization of the overall inspection process. Through holistic approach, MINOAS proposes the development of a new infrastructure that substitutes human personnel by high locomotion enabled robots and ‘teleports’ the human inspector from the vessel’s hold to a control room with virtual reality properties. The human’s perceptual abilities are enhanced through the utilization of high resolution tools (eg sensors) and are augmented through the parallel processing property provided by MINOAS. Following the centralized control scheme adopted in similar distributed control methodologies (SCADA), the number and the sequence of the tasks required is rearranged and the overall inspection procedure is brought in alignment with the current tendency adopted in similar inspection, exploration and surveillance tasks. The proposed innovative system concept, considers the assembly of a robot fleet with advanced locomotion abilities and sets of tools that are dedicated to the tasks attached to the inspection process, the development of control techniques and algorithms that provide a semi-autonomous nature to the operation of the robot-fleet and a hierarchical controller that realize the virtual environment for the human inspector and adds newly developed toolboxes enabling on-line processing of the harvested data and operate as a Decision Support System in the aid of the inspector.

Keywords: inspection,marine inspection,robot,robotic assistant,classification society,inspection cost
DEveloping the MObility CRedits Integrated platform enabling travellers to improve urban TranspOrt Sustainability (DEMOCRITOS)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: HORIZONTAL ACTIVITIES for implementation of the TRANSPORT PROGRAMME
Action type: Collaborative project
Countries involved: Italy,Portugal,Romania,Italy,Germany
Call:  (FP7-TPT-2008-RTD-1, 2008)
Start date: 2009-10-01
End date: 2011-09-30
Duration (months): 24.0
Total project cost (EUR): 1741707.07
EU funding (EUR): 1358614.0
Participants: 9
Project status: CLOSED

The 24 months project introduces the Mobility Credits Model as a transport specific platform that will enable travellers, mobility providers, technology providers and transport planners to understand the implications of climate policy and increasing prices for greenhouse gas emissions and to identify new opportunities in urban mobility first and in extra-urban mobility later. The concept of the Mobility Credit Model is based on four basic pillars: define a sustainable load of GHG (GreenHouse Gas) in an urban area; convert this load into a “total amount of credits”, that will become the common “currency” to be spent within the assigned budget limits using an Electronic GHG wallet, and will be distributed to all the travellers; define a set of rules to use the credits; exchange credits allowing travellers with a negative balance of credits to buy extra-credits from other travellers who are credit-positive. The Mobility Credits Platform (MCP) allows to create a behavioural context where the travellers can experience the effects of changing attitudes and choices in mobility with a range of possible implementations, from a “pedagogic tool” to a “mandatory demand management scheme”, from a “social network” to “enterprise applications”. The project will proceed through the development of a comprehensive and consistent theoretical framework in order to provide a solid background addressing all the implementation issues and effects of the integrated platform; the definition of the system and technology architecture, the assessment of the long term effects of the MCP, in particular the impact on local competitiveness due to re-location effects. The theoretical framework will be then tested in the four urban areas of Genova, Stuttgart, Lisboa and Craiova through simulations and a first demonstration pilot; results will be compared for finalizing the MCP scheme both for the participating cities and for other European municipalities.

Keywords: mobility credits,environmental awareness,urban congestion,greenhouse gas reduction,information platform,traveller behaviour