Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
REalistic Simulations and ObservationaL Validation of small-scale Energy channels on the Sun (RESOLVE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Sun-like stars possess magnetically confined, upper atmospheres. These coronae have temperatures of several million degrees and thus are much hotter than the underlying stellar surfaces (photospheres) which have temperatures of the order of 6000 degrees. The coronae are hotter than the photospheres because magnetic energy is generated by convective motions beneath the stellar surface and then transported through the photosphere into the corona where it is dissipated. The key to understanding the heating of the corona is to determine how, and at which spatial and temporal scales, energy is being transported into the stellar atmosphere. Both theory and simulations suggest that a substantial fraction of the energy transfer happens at spatial scales smaller than those currently observationally resolvable. The main goal of the proposed research is to bridge this gap between what we expect from theory and what we can observe. The proposed research will use numerical simulations to characterize the energy flux and look for its (spectropolarimetric) signature. This signature will then be used to create maps of the energy flux on the actual Sun using the highest-resolution observations (50-70 km) which are available: those from the 1-meter Sunrise balloon-borne observatory, and the 1.5-meter GREGOR, Europe's largest solar telescope. We will validate the diagnostics by comparing these maps of the observed energy flux into the solar atmosphere with co-spatial observations of the hot plasma structures seen in the upper atmosphere. Understanding the energy transfer combines the strengths of advanced simulations and the unprecedented observations as well as combining the expertise of world-leading solar groups in Germany and Spain. This research will have a major impact on our understanding of the heating of upper atmosphere. It is the ideal project and set of collaborations to further the experienced researcher's scientific career.

Keywords: astrophysics,solar physics,simulations,spectropolarimetry
effiCient mineral processing and Hydrometallurgical RecOvery of by-product Metals from low-grade metal contaIning seCondary raw materials (CHROMIC)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Italy,Slovakia,Belgium,Belgium,Belgium,Belgium,Belgium,France
Call: New solutions for sustainable production of raw materials (H2020-SC5-2016-OneStageB, 2016)
Start date: 2016-11-01
End date: 2020-12-31
Duration (months): 50.0
Total project cost (EUR): 4869687.5
EU funding (EUR): 4869687.5
Participants: 12
Project status: CLOSED

Europe is faced with the challenge of sustaining a secure supply of by-product metals, which play a fundamental role in the competitiveness of the manufacturing sector and innovations in high-tech sectors. To loosen the growth restrictions imposed by the inflexible supply from primary mining, alternative sources for these metals must be explored. At the same time a wealth of metals is entrapped within the vast amounts of secondary resources still being landfilled or used in applications where their intrinsic value is not fully utilized. To unlock the potential of these resources, a radically new approach to metal recovery must be deployed. Crucial factor within this new value chain is the zero-waste approach, which captures not only the contained metals but also valorises the residual matrix (often >95% of the bulk material). Such an approach requires the development of innovative, highly selective metal recovery technologies that fully capture the metal-value without impairing the properties of the residual matrix material for valorisation. CHROMIC aims to develop such new recovery processes for critical (Cr, Nb) and economically valuable (Mo, V) by-product metals from secondary resources, based on the smart integration of enhanced pre-treatment, selective alkaline leaching and highly selective metal recovery across the value chain. An overarching assessment of the related economic, environmental and health and safety aspects will be carried out in an iterative way to ensure that the developed technologies meet the requirements of the circular economy whilst being in line with current market demand. The technology will be developed for two models streams (stainless steel slags and ferrochrome slags) with the potential of replication to numerous industrial residues across Europe. Involvement of society from early on will smooth the path towards implementation, so that the CHROMIC processes can contribute to securing Europe’s supply of critical raw materials.

Keywords: critical and by product metals,cost,energy,material efficiency
Commercialization of open vesicles to fuel downstream reaction networks (FuelVesicles)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-07-01
End date: 2021-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Numerous biotechnological processes require Adenosine-5'-triphosphate (ATP) as a form of free energy to drive endergonic reactions. The bottleneck is that after some time the reaction stops due to adenosine diphosphate (ADP) build up and the depletion of energy reserves. In living cells, functional and sustainable out-of-equilibrium networks exist. Scientists have tried to mimic such autonomous systems without the need for external interaction, or fuel supply. Real success hasn’t been reported. We managed to construct a fuel system in synthetic vesicles that is kept away from equilibrium by controlling the energy dissipation. These vesicles are power houses for sustainable production of ATP (and removal of ADP) much like mitochondria power the ATP-demanding reactions in the cytosol of a cell. In further tests, we were able to reach an order of magnitude longer autonomous operation of a real-life application making our approach truly unique. All the comparable approaches focus on feeding the reaction with ATP without draining of the ADP. Our system creates the fuel from an amino acid while the ATP/ADP ratio is kept constant. The gain for applications is evident; the reactions, and therefore systems, can operate autonomously for long periods of time. This is particularly important for mobile systems with limited supply of reaction materials and where user intervention has to be minimal. Therefore, we expect to enable a completely new generation of autonomous biotech and chemistry applications, such as targeted drug delivery, analytics of nucleic acids or proteins, and cascade reactions for (bio)chemical syntheses of antibiotics, vitamins and other complex molecules. In this PoC, we will advance the commercialization of our approach by carrying out a technical feasibility for sustainable production of ATP for long-lasting sequencing of DNA application. In addition, we will prepare a commercialization plan, carry out partnering actions and strengthen the IP further.

Keywords: synthetic vesicles,out of equilibrium network,sustainable production of atp,synthetic biochemistry,nanopore sequencing,membrane transport,biosensing,autonomous operation,next generation sequencing of dna
loW Altitude Remote sensing for the Monitoring of the state of Cultural hEritage Sites: building an inTegrated model for maintenance. (Warmest)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Italy,Italy,Spain,Italy,Italy,Greece,Poland
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2017-12-01
End date: 2022-12-31
Duration (months): 61.0
Total project cost (EUR): 1296000.0
EU funding (EUR): 1296000.0
Participants: 10
Project status: SIGNED

WARMEST strategic goal is to create a novel comprehensive Decision Support System that will carry out a Cultural Heritage Risk Analsys (CHRA) and suggest improvements in maintenance and disaster management procedures for cultural and natural heritage sites. The maintenance and disaster management plans developed with the support of the Decision Support System, will consider current and future scenarios, setting priorities for the actions to be taken, both on economic and art historical grounds, delivering required information where and when needed, in a user-friendly way. To this end the consortium will develop new technologies to collect data on the conservation status of the sites and new tools to analyse it, as there is presently a lack of data that is specifically relevant to understanding climate change impacts; these technologies in case of emergence, can help to assess the impact of events quickly and on large areas. WARMEST is challenging from a management and from an engineering point of view, given that regulations are strict (to preserve the natural, archaeological and historical values), the factors to take into consideration are complex and not homogenous (technical, economic, historical), the information to deliver differentiated according to users and concise or detailed when needed. The goals set by WARMEST can be met only by creating an heterogeneus consortium, involving knowledgeable experts from various fields from private and public institutions. 9 beneficiaries will participate to the WARMEST consortium; 3 academic institutions, 2 association involved in heritage management and 4 private companies. 4 end users will be commited to the project as external partners to obtain the right mixing of knowledge.

Keywords: predictive maintenance,risk assesment
REMARKABLE Climate Leaders Achieving 2050 Climate Neutrality (REMARKABLE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Austria,Ireland,Spain,Belgium,Croatia,Slovenia,Slovenia,Sweden,France
Call: Supporting public authorities in driving the energy transition (H2020-LC-SC3-EE-2020-2, 2020)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 1653357.5
EU funding (EUR): 1653357.5
Participants: 11
Project status: SIGNED

REMARKABLE will support local leaders to deliver a step change in progress towards carbon neutrality by 2050 in 7 regions across Europe. REMARKABLE will establish, by 2024, a network of 320 Current and Emerging Climate Leaders who, through their actions and inspiration, will drive their municipalities, public authorities, communities and regions to transform their approaches from ones focused on energy efficiency/renewables to ones focused on the strategic goal of climate neutrality by 2050. REMARKABLE will build new leadership capacity in 120 actors from 7 countries in Europe though a Climate Leadership Programme (CLP). The CLP will be inspired by ethnographic research and will be designed with and for leaders across public authorities. The REMARKABLE CLP will also facilitate the creation of 60 Roadmaps for public authorities aiming at Climate Neutrality by 2050. These Roadmaps will allow our Climate Leaders to translate strategic aspirations and policy ambitions into concrete and disruptive far reaching measures stimulating €300m investment by 2030. A Climate and Energy Check Tool will be developed and tested along with a Climate Neutrality Roadmap Guide. The 7 Regional Energy Agencies involved in REMARKABLE will develop 14 new services to expand their roles as change agents in the Clean Energy Transition and Climate Neutrality challenges. Climate Neutrality Training, Climate One Stop Shops, Financing Solutions are targeted as potential services. REMARKABLE will exploit its outcomes and results through the creation of an EU Climate Leaders Circle, reaching up to 320 members by 2024 including 30 from 7 Observer Regions/Countries. An innovative Climate Neutrality Challenge will be organised for Young Climate Leaders. The REMARKABLE Circle will create synergies with existing networks and initiatives e.g. COMO, ManagEnergy to support and enhance their impacts with the ambition of mobilising 10,000 stakeholders by 2030 (2,000 by 2024)

Keywords: climate leaders,public authorities,climate neutrality,enthnograpy
Characterisation of DNA Double-Strand Break Repair by Alternative End-Joining: Potential Targets for Cancer Therapy (altEJrepair)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-07-01
End date: 2023-06-30
Duration (months): 72.0
Total project cost (EUR): 1498750.0
EU funding (EUR): 1498750.0
Participants: 2
Project status: SIGNED

DNA repair pathways evolved as an intricate network that senses DNA damage and resolves it in order to minimise genetic lesions and thus preventing tumour formation. Gaining in recognition the last few years, the alternative end-joining (alt-EJ) DNA repair pathway was recently shown to be up-regulated and required for cancer cell viability in the absence of homologous recombination-mediated repair (HR). Despite this integral role, the alt-EJ repair pathway remains poorly characterised in humans. As such, its molecular composition, regulation and crosstalk with HR and other repair pathways remain elusive. Additionally, the contribution of the alt-EJ pathway to tumour progression as well as the identification of a mutational signature associated with the use of alt-EJ has not yet been investigated. Moreover, the clinical relevance of developing small-molecule inhibitors targeting players in the alt-EJ pathway, such as the polymerase Pol Theta (Polθ), is of importance as current anticancer drug treatments have shown limited effectiveness in achieving cancer remission in patients with HR-deficient (HRD) tumours. Here, we propose a novel, multidisciplinary approach that aims to characterise the players and mechanisms of action involved in the utilisation of alt-EJ in cancer. This understanding will better elucidate the changing interplay between different DNA repair pathways, thus shedding light on whether and how the use of alt-EJ contributes to the pathogenic history and survival of HRD tumours, eventually paving the way for the development of novel anticancer therapeutics. For all the abovementioned reasons, we are convinced this project will have important implications in: 1) elucidating critical interconnections between DNA repair pathways, 2) improving the basic understanding of the composition, regulation and function of the alt-EJ pathway, and 3) facilitating the development of new synthetic lethality-based chemotherapeutics for the treatment of HRD tumours.

Keywords: dna repair,alternative end joining,homologous recombination,synthetic lethality
Establishing innovative approaches for optimal infection prevention of resistant bacteria in NICUs by integrating research, implementation science and surveillance in a sustainable global platform (NeoIPC)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Germany,Estonia,South Africa,Spain,Spain,Italy,Switzerland,Belgium,Greece,Switzerland,Netherlands,United Kingdom
Call: New approaches for clinical management and prevention of resistant bacterial infections in high prevalence settings (H2020-SC1-2020-Single-Stage-RTD, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 9999816.75
EU funding (EUR): 9999816.75
Participants: 13
Project status: SIGNED

Around 10% of newborns in Europe will be admitted to a neonatal intensive care unit (NICU). Critically ill babies are a highly vulnerable population for the acquisition of resistant bacteria. Sepsis is among the most common events in NICU and is known to be associated with high mortality and poor long-term outcomes. Despite rising awareness of high rates of resistant bacterial colonisation reported in NICU, there is very little robust specific data on globally applicable infection prevention and control (IPC) measures. NeoIPC focuses on new approaches to the prevention and management of resistant bacterial colonization and infection on NICU. The project builds on and further extends the collaboration between 13 partners with a proven track record in relevant areas, including neonatal infection, IPC, implementation science, microbiology and surveillance. NeoIPC aims to develop and implement an innovative approach towards the evaluation of IPC interventions combining a robust cost-efficient randomised trial combined with the evaluation of a suitable implementation science strategy and novel targeted clinical and genotypic surveillance. A further goal is to generate widely relevant pan-European network strategies to improve IPC in routine neonatal care. This will be achieved through six interrelated work packages to deliver a cluster randomised trial-implementation hybrid investigating the impact of skin antisepsis on infant hospital-acquired clinical sepsis and resistant bacterial colonisation, coupled with a comprehensive implementation strategy incorporating optimal targeted surveillance in a clinical network with tailored dissemination and exploitation to facilitate sustainable embedding of outputs. NeoIPC will generate globally transferrable outputs to reduce hospital transmission of resistant pathogens, foster and facilitate collaborative research and IPC implementation efforts with a broad and long-lasting impact for critically ill newborns and infants.

Keywords: infection prevention and control,neonatal intensive care,resistant bacterial infection,cluster randomised trial,clinical practice networks,implementation science,resistance surveillance
DIGital traNsport In and for socieTY (DIGNITY)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Italy,Italy,Belgium,Belgium,Netherlands,Netherlands,United Kingdom
Call: An inclusive digitally interconnected transport system meeting citizens' needs (H2020-MG-2019-SingleStage-INEA, 2019)
Start date: 2020-01-01
End date: 2022-12-31
Duration (months): 36.0
Total project cost (EUR): 2750367.5
EU funding (EUR): 2750367.5
Participants: 15
Project status: CLOSED

DIGNITY will delve into the digital transport eco-system to grasp the full range of factors that might lead to disparities in the uptake of digitalised mobility solutions by different user groups in Europe. Analysing the digital transition from both a user and provider’s perspective, DIGNITY will present the challenges brought about by digitalisation, and design, test and validate the DIGNITY approach, a novel concept that seeks to become the ‘ABCs for a digital inclusive travel system’. The project will build the approach step by step and provide a methodology to frame the digital gap in metropolitan/regional contexts, considering all elements of the digital transport ecosystem: the institutional framework (macro level), the provision of digital mobility (meso level) and the needs of end users (micro level). It will then combine proven inclusive design methodologies with the principles of foresight analysis to examine how a structured involvement of all actors - local institutions, market players, interest groups and end users - can help bridge the digital gap by co-creating more inclusive mobility solutions and by formulating user-centred policy frameworks. DIGNITY will demonstrate the approach in 4 pilots: Barcelona (ES), Tilburg (NL), Ancona (IT) and Flanders (B). The evaluation of DIGNITY’s potential and the impacts generated in the pilots will lead to conclusions and policy recommendations for wider uptake. Practical applications for designing inclusive digital transport in the form of the DIGNITY toolkit will help public authorities, transport operators and private providers consider the needs and requirements of all users in their decision-making processes. To fully exploit DIGNITY’s research results and the knowledge acquired to a broad audience, a Learning Community will be created, to raise awareness of the social implications of the digital transition and encourage the adoption of the DIGNITY approach.

Keywords: digital travel eco system,users centre approach,social inclusion and cohesion,inclusive design,forward looking analysis