Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PRINCIPLES OF AXIAL POLARITY-DRIVEN VASCULAR PATTERNING (AXIAL.EC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Portugal
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2022-02-28
Duration (months): 66.0
Total project cost (EUR): 1618750.0
EU funding (EUR): 1618750.0
Participants: 1
Project status: CLOSED

The formation of a functional patterned vascular network is essential for development, tissue growth and organ physiology. Several human vascular disorders arise from the mis-patterning of blood vessels, such as arteriovenous malformations, aneurysms and diabetic retinopathy. Although blood flow is recognised as a stimulus for vascular patterning, very little is known about the molecular mechanisms that regulate endothelial cell behaviour in response to flow and promote vascular patterning. Recently, we uncovered that endothelial cells migrate extensively in the immature vascular network, and that endothelial cells polarise against the blood flow direction. Here, we put forward the hypothesis that vascular patterning is dependent on the polarisation and migration of endothelial cells against the flow direction, in a continuous flux of cells going from low-shear stress to high-shear stress regions. We will establish new reporter mouse lines to observe and manipulate endothelial polarity in vivo in order to investigate how polarisation and coordination of endothelial cells movements are orchestrated to generate vascular patterning. We will manipulate cell polarity using mouse models to understand the importance of cell polarisation in vascular patterning. Also, using a unique zebrafish line allowing analysis of endothelial cell polarity, we will perform a screen to identify novel regulators of vascular patterning. Finally, we will explore the hypothesis that defective flow-dependent endothelial polarisation underlies arteriovenous malformations using two genetic models. This integrative approach, based on high-resolution imaging and unique experimental models, will provide a unifying model defining the cellular and molecular principles involved in vascular patterning. Given the physiological relevance of vascular patterning in health and disease, this research plan will set the basis for the development of novel clinical therapies targeting vascular disorders.

Keywords: angiogenesis,endothelial cells,vascular patterning,cell polarity
TUTOR: A universal Learning Management System for Robot-based learning (TUTOR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-12-18
End date: 2018-12-17
Duration (months): 12.0
Total project cost (EUR): 100875.0
EU funding (EUR): 100875.0
Participants: 1
Project status: CLOSED

In this digital age, a change in learning/teaching method is being fuelling by the introduction of Information and Communication Technologies (ICT) and interactive media (digital whiteboard, tablets, robots, etc.) in schools. Among them, the use of robots with age-school children improves their motivation and learning process by 75%. A notable obstacle to implement robotics widely as part of schools’ curriculum appears to be the involvement needed from educators (teachers, therapists, etc) in the generation of contents and experiences, which today requires programming or coding knowledge. Aiming at overcoming this barrier, our company InterOnLine has developed TUTOR, a novel Learning Management System for leveraging education based on the use of robots, that allows non-computer skilled users create, manage and transfer learning units (LUs) for robots out-of-the-box. We have detected our potential capabilities to define and design our own educational robot in which run TUTOR, in order to maximize the business opportunity in the innovative Robot-Learning sector. This way, we will develop a fully functional product (LMS software + hardware) that will provide a mechanism for our sustainable growth. By enrolling an Innovation associate we will be able to leverage this innovation strategy. In order to achieve the objectives for develop and implement TUTOR project, we need to reinforce our team with a PhD in robotics engineering with knowledge and experience in educational and pedagogic methodologies. The recruitment of the IA will help us to accelerate the high growth of our company, by means of the following expected impacts: reinforcing experience and knowhow of our team, developing the new line of products for the future of our company and boosting our business opportunity, reaching 4M€ by 2020 once full product has been launched.

Keywords: e learning,robotics
Children obesity and changing habits (COACH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-08-21
End date: 2019-08-20
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Children obesity and changing habits (COACH) The prevalence of obesity in children and adolescents has increased rapidly in developed countries across the globe and has become a concern for its potential negative consequence on health. The prevalence rate of obesity among children and adolescents in developed countries is over 20% and in the UK it is even higher than 25%. The COACH project aims at assessing the determinants of obesity and overweight in children by looking at their eating habits and active lifestyle and evaluating (1) how changes in health habits can help reducing child obesity; (2) how these habits can be modified trough three mechanisms which are: I. the transmission of healthy habits from parents to children, II. the effect of environmental factors, III. the effect of habits of the child’s peers. Parents can have a big role in transmitting healthy habits and obesity to their children. Children whose parents have bad eating habits and sedentary lifestyles may end up acquiring the same type of habits. Similarly children habits can be affected by the lifestyle and behaviour of other children they share their time with, e.g. siblings and school mates. Finally, a big influence on children’s health habits may come from the environment where they live. Environments with a lack of parks and green spaces, cycle paths and road safety can impede an active lifestyle. Similarly bad eating habits can be promoted by environments with an abundance of fast-food restaurants and a scarcity of shops providing quality fruits and vegetables. Assessing the relative importance of different mechanisms affecting child’s habits and identifying which among different health habits is most malleable and has the largest effect on obesity will inform policy makers on how to design more cost effective strategies to tackle obesity.

Keywords: health,obesity,life style habits,body mass index,children,adolescents
Next Generation Instrument for In-Depth Analysis of Mitochondrial Fitness (NextGen-O2k)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-06-01
End date: 2021-10-31
Duration (months): 29.0
Total project cost (EUR): 2357732.5
EU funding (EUR): 1650412.75
Participants: 1
Project status: CLOSED

Mitochondria and chloroplasts are key elements to face the new challenges of the millennia for biomedicine, biotechnology and to develop a sustainable bio-economy. Mitochondrial fitness is a key parameter for diagnosis and therapeutic applications on multiple human pathologies, such as neurodegenerative diseases, diabetes and cancer. On the other hand, the optimization of algal growth rate and metabolite production in biotechnology requires novel investigations and monitoring of the bioenergetic pathway control exerted by mitochondria and chloroplasts. However, current technologies to study mitochondrial and chloroplast function are limited, providing segmented information, lacking inter-laboratory reproducibility and hindering our advance towards therapeutic and biotech interventions of cellular bioenergetics. As a result, the understanding of cellular bioenergetics for medical and algal biotechnology applications remains poor. The overall objective of this project is to complete the development of NextGen-O2k and prepare its market launch in 2021. NextGen-O2k is a multi-sensor platform for in-depth study of mitochondrial and chloroplast functional fitness. In a compact and affordable device, we have integrated several sensors for detecting multiple key parameters of bioenergetics, with superior resolution and reproducibility. With NextGen-O2k we will provide researchers with a tool able to improve knowledge about mitochondrial dysfunction and chloroplast photosynthesis, while bringing savings in experimental time, samples and funds. NextGen-O2k project is a step forward towards understanding mitochondrial implication in human pathologies and in the optimization of biomass production in many areas of biotechnology. Our focus in on generating knowledge about mitochondrial function and dysfunction, chloroplast photosynthesis and algal metabolism, while contributing to address the science reproducibility crisis.

Keywords: mitochondrial dysfunction,ageing,medical device,mitochondrial respiration
Multiple Intelligent Conversation Agent Services for Reception, Management and Integration of Third Country Nationals in the EU (WELCOME)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Innovation actions
Countries involved: Germany,Spain,Spain,Germany,Germany,Germany,Spain,Greece,Greece,Czechia,Czechia,United Kingdom
Call: Addressing the challenge of migrant integration through ICT-enabled solutions (H2020-SC6-MIGRATION-2019, 2019)
Start date: 2020-02-01
End date: 2023-04-30
Duration (months): 39.0
Total project cost (EUR): 4272870.0
EU funding (EUR): 3995709.0
Participants: 16
Project status: SIGNED

The objective of WELCOME is to research and develop intelligent technologies for support of the reception and integration of migrants in Europe. Unlike the majority of the projects that address the problem of migrant integration by frontends with “one-for-all” interfaces for information acquisition and services, WELCOME will offer a personalized and psychologically and socially competent solution for both migrants and public administrations. It will develop immersive and intelligent services, in which embodied intelligent multilingual agents will act as dedicated personalized assistants of migrants in contexts of registration, orientation, language teaching, civic education, and social and societal inclusion. The agents will be personalized in the sense that they will dynamically adapt their interaction behavior to the topic, given context and the profile of the interlocutor. To provide “real-life” experience and thus deeper and swifter integration, immersive virtual and augmented reality technologies will be used. For public administrations, decision support technologies that will draw upon visual analytics and semantic reasoning techniques will be developed. To achieve its objective, WELCOME will innovate in the areas of human – multiple service-oriented agent interaction, multilingual spoken language technologies, knowledge processing, immersive personalized education and social inclusion technologies, and decision support strategies. WELCOME’s solution will be validated and its portability to different European contexts demonstrated in three pilot use cases. Both WELCOME as a whole and its individual technologies are expected to have a very significant societal and economic impact. WELCOME counts with a highly competent Consortium of 15 partners: 6 research institutions, 3 ICT companies, and 6 entities related to migrant reception and integration. To increase its impact and dissemination, WELCOME involves the International Migrant Organization as subcontractor.

Keywords: personalized embodied conversation agents,language teaching,social and societal inclusion,decision support,multilingual language technologies,virtual,augmented reality,knowledge processing
Topological Explorations with a Clip: New Molecular Nanocarbons (TOPOCLIP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Switzerland,Netherlands
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 1499625.0
EU funding (EUR): 866143.0
Participants: 2
Project status: SIGNED

The lack of synthetic control over the chirality of curved carbon nanostructures derived from graphene, such as carbon nanotubes (CNTs), prevents the development of molecular electronics applications that require high purity and uniformity of these materials. Single- and multi-walled CNTs are typically formed as a mixture of chiral, armchair, and zigzag nanostructures that significantly differ in their properties. The urgency of controlled chirality-specific synthesis of CNTs advanced the synthesis of curved molecular nanocarbons – molecular precursors for a stepwise synthesis of uniform single-walled CNTs. Applications in bioimaging, sensing, catalysis, and organic electronics have been rapidly emerging on account of the unusual properties of these hoop-like molecular nanocarbons. To this date, no analogous molecular precursors for topologically more complex carbon nanostructures such as double-walled CNTs or carbon nanoscrolls exist because their topologies do not yet have a stable molecular representation. TOPOCLIP develops such stable molecular representations, enables their synthesis by using a molecular clip, and delivers unprecedented topological molecular nanocarbons. The molecular clip helps controlling the curvature, preserves the electronic communication throughout the molecular nanocarbon structure, or allows construction of the first molecular nanocarbon with a reversible dynamic behavior. TOPOCLIP (1) improves our understanding of strain and non-covalent interactions that (de)stabilize curved nanocarbons, (2) delivers responsive nanocarbons that can alter shape with an external stimulus, and (3) establishes design principles for tailor-made molecular nanocarbons for future nano- and biotechnology applications. Ultimately, TOPOCLIP takes the vital step to find a solution to a long-standing challenge: the chirality-specific synthesis of carbon nanostructures of complex topologies obtained by rolling-up a graphene sheet beyond the single-walled CNTs.

Keywords: physical organic chemistry,molecular carbon based materials,curved aromatic molecules,paracyclophane,polycyclic aromatic hydrocarbons,photoswitching,structure property relationships
Seeking Constraints on Open Ocean Biocalcification (SCOOBi)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 2483490.0
EU funding (EUR): 2483490.0
Participants: 1
Project status: SIGNED

Coccolithophores and foraminifera, single-celled mineralising plankton, convert atmospheric CO2 into limestone. Together, they produce over 2 billion tonnes of calcite/year. Anthropogenic change creates myriad threats to the future of marine calcifiers, the foundation of the ocean ecosystem and global carbon cycle. Much work has focussed on the impact of acidification and declining carbonate saturation state on calcifier mineralisation. But the modern ocean is four times supersaturated with respect to calcite. Hence SCOOBi asks: What limits modern marine calcification rates? How will they respond to future change? All modern marine carbonate producers are solar-powered and rely directly on photosynthesis. To understand how calcification rates are limited, it is necessary to discover how the environment controls the flow of energy from photosynthesis to calcification. Controls on calcification rates have been elusive until now. Experimental manipulations of calcifiers test only immediate physiological responses. Palaeomethods suffer from preservational artefact, including dissolution of ¾ of all calcite produced. For the first time, a unique merger of cutting-edge approaches allows the calcification efficiency of species, and calcite production rates of communities, to be reconstructed from the geological record. Using an ambitious and high risk-high reward combination of genetics, (palaeo)metabolomics, (palaeo)physiology, and stable isotope geochemistry, SCOOBi will document and build a mechanistic understanding of pelagic calcification rates and transform our ability to predict their response to environmental change. It uses the natural laboratory of sediments to reveal how environmental factors select for calcification efficiency, which can be validated experimentally. SCOOBi will test the controversial hypothesis that pelagic calcification is limited by carbon and phosphate availability in the modern ocean, and pelagic calcifiers will flourish into the future.

Keywords: biomineralisation,ocean carbonate system,pelagic
AQUABUDDY-CARE: A Groundbreaking Solution for Elderly and Disabled people with Reduced Mobility that Finally Enables Caregivers to Effectively and Safely Bathe/Shower them in their own Beds. (AQB-CARE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2017-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The progressive ageing of the population is becoming a major problem for society, who sees how ageing comes accompanied by crucial challenges that constraint our healthcare systems. Dependency is one of these challenges, adopting today the form of over 3 million Europeans unable to live independently due to ageing, disease, accidents or long term disability. These individuals rely and depend on caregivers to accomplish daily activities, being hygiene one of the most critical steps. Fulfilling hygiene tasks becomes specially challenging and time-consuming for the saturated personnel at hospitals, clinics or elderly homes, who need to be extra careful with these patients at higher risk of infection. The complexity of the current processes to wash or bathe bedbound patients (which involves transferring the patient out of bed) enters in conflict with the workload pressure faced by caregivers (which limits the time available for each patient). In response, we have developed and validated Aquabuddy-CARE (AQB), a miniaturized and portable shower system that enables patients to undertake hygiene tasks in bed, rapidly and in a dignified manner. The combination of advanced materials, sustainable production process and proprietary water flow system guarantees the efficiency of the technology concerning water consumption and prevention of contamination. After completing the validation at the pilot scale, this project aims to finalise the industrialization and field-testing of AQB. The Feasibility Study planned in Phase 1 will help us secure the project from all technical, financial and commercial standpoints. Once in the market, AQB will bring significant benefits for caregivers and patients worldwide, helping to alleviate the raising impact of ageing and disability while improving their life quality. In turn, AQB will boost our growth, expecting to hire 12 new people in 5 years, gain €11.2 million in profits and reach a ROI of 4.6 per euro invested in the project.

Keywords: healthcare challenges,bedbound population,antimicrobial devices,impaired mobility,sustainable healthcare,patented materials,hygiene standards,water efficiency,patient wellbeing,green manufa