Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Perceptual functions of Drosophila retinal movements and the underlying neuronal computations (FlyActiveComp)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-08-01
End date: 2029-07-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Sensory perception is often an active process, and many animals move their sensory organs to actively shape their interactions with the outside world. Active sensing can provide animals with important information that impacts their survival and overall fitness. We recently found that Drosophila adjust their visual input by moving their retinas underneath the stationary lenses of the compound eye. The discovery of retinal movements in the fly provides us with a fantastic toolbox to study the cellular mechanisms of active visual computation. We found several types of Drosophila retinal movements, including an optokinetic reflex that likely helps gaze stabilization. The functions of other types of retinal movements we described remain to be shown. We found tiny movements that shift the retina only by a fraction of the angle between photoreceptors, resembling so-called ‘microsaccades’ in primates. In humans, these eye movements happen during visual fixation and their functions are still not entirely clear. We want to understand how flies, which have a very different visual system, benefit from such movements. We also found large convergent, or cross-eyed, retinal movements that happen when flies cross obstacles in tethered walking. Genetic silencing of retinal motoneurons suggested a role of these movements in depth perception. We will probe the visual system during vergence movements to understand how the neural system uses dynamic input to gauge distances. The overarching goal is to unravel neuronal computations that use actively generated visual input to extract information about the world. The fly’s relatively simple nervous system, its rich visual behavior, and outstanding experimental tools will allow for detailed insights into active sensory computation on a cellular level. Results from this work will generate novel insights into how evolutionary distant brains solve similar visual challenges and elucidate differences and common principles across species.

Keywords: drosophila,active vision,eye movements,depth perception,spatial acuity,compound eye
Promoting RObust Systems biology on Patients and Experimental models with obesity-driven liveR cancer (PROSPER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 183600.96
EU funding (EUR): 183600.96
Participants: 1
Project status: SIGNED

In obesity, pathological expansion of adipocytes leads to increased adipose tissue macrophage (ATM) amounts and adipocyte death. Adipocyte death in turn is linked to ectopic lipid spillover and metabolically triggered inflammation which is a risk factor for diseases such as cancer, particularly hepatocellular carcinoma (HCC) that is linked to nonalcoholic steatohepatitis (NASH). Hepatic fat accumulation leads to chronic hepatocyte metabolic and oxidative stress resulting in cell damage and death. Although oxidative damage, microbiome dysbiosis, mitochondrial dysfunction, sterile inflammation are important in promoting NASH and fibrosis and cirrhosis are crucial for HCC development, the exact trigger(s) remain unknown. In HCC tumor cells take up nutrients, including lipids, to support their proliferation and solid tumors in HCC are characterized by enhanced hypoxia and acidosis resulting from a locally modified metabolism. Beyond malignant cells, the tumor-microenvironment (TME) contains immune cells including tumor-associated macrophages (TAMs) and dendritic cells. TAMs are pro tumorigenic, sabotaging anti-tumor immunity through various mechanisms. Notably, TAMs’ tumour-suppressive phenotype is directly linked to their lipid loading and disrupting lipid formation in TAMs attenuates tumor growth. Further, in the TME, dendritic cells are triglyceride laden, which contributes to immunosuppression by impairing their ability to present antigen. Despite advancements, a systems approach to understand the exact metabolites and lipid species in obesity driven HCC remains a challenge. Moreover, which metabolites are adipocyte-derived or locally produced within the liver remains unclear. Here using systems biology, coupled to NASH and NASH driven HCC animal models as well as patient cohorts spanning the NAFLD, NASH and HCC spectrum, we aim to identify which factors produced by adipose and the liver regulate obesity driven HCC and contribute to immunosuppression.

Keywords: obesity,cancer,nash,hcc,metabolites,lipids,systems biology,transcriptomics,immunology
Enantioselective strategies for the synthesis of phenyl bioisosteres (EnantioBioIso)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: SIGNED

The obtainment of enantioenriched molecules is of fundamental importance since two enantiomers of the same drug candidate can display completely different biological properties. In recent years, an increasing interest in employing saturated scaffolds has been observed in medicinal chemistry since they provide tridimensionality and well-defined exit vectors that give access to novel unexplored chemical space, leading to a higher success in drug discovery programs. Among them, some polycyclic bridged skeletons have been identified as suitable saturated bioisosteres of aromatic rings which represent the common two-dimensional, flat moieties that are routinely employed in the drug discovery process. The aim of EnantioBioIso is to provide novel enantioselective strategies for the synthesis of phenyl bioisosteres, enabling unprecedented approaches to obtain bridged skeletons that are of fundamental importance for medicinal chemistry.

Keywords: bioisosteres,asymmetric catalysis,enantioselective synthesis,lewis acid catalysis,organocatalysis,transition metal catalysis,photocatalysis
Exclusionary environments of the emerging energy and political transitions (EXEMPT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-15
End date: 2026-10-14
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Exclusionary environments of the emerging energy and political transitions (EXEMPT) looks at the underpinning exclusions evident in different ideological varieties of environmentalism and environmental policies. Through an interdisciplinary theoretical and methodological approach, building on insights from environmental sociology, politics, psychology, anthropology and economics, EXEMPT will examine the understudied contexts of Serbia and Montenegro, as epistemic semi-peripheries in which a wide array of environmental concerns has only recently become recognized at a larger scale. The fundamental aim of EXEMPT is thus to examine the environmental imaginaries and their related ideological underpinnings in light of the explicit and implicit exclusions in the emerging contexts of environmental activism and policy. To reach this aim, EXEMPT builds on three fundamental building blocks - objectives: the first is to conceptualize "exclusionary environmentalisms" by explaining how different imaginaries and ideologies underpin exclusion, developing an "environmental imaginaries scale" in the process, a tool that could be used in future quantitative or mixed-methods inquiries. The second objective is to explore, through the use of digital ethnography and qualitative interviews, how "microfascism" - silent exclusion and tacit elimination of the "unwanted" elements in an imaginary, occurs in the everyday environmental activism and policy. Much as exclusion is a constitutive part of identity building, hence of politics, the third and final objective of EXEMPT is also to explore and test the communicative ways in which exclusion can be mitigated in an attempt to 'open' environmentalism to different imaginaries, experiences and geographies. As such, this project points to both theoretical and practical ways of identifying, examining and addressing activist and policy exclusion.

Keywords: environment exclusion policy energy serbia montenegro microfascism silence imaginary ideology mixed methods qualitative interviews digital ethnography quantitative methods semi periphery
Fishing Architecture: The Ecological Continuum between Buildings and Fish Species (FISH-A)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Portugal
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 2001468.0
EU funding (EUR): 2001468.0
Participants: 1
Project status: SIGNED

To what extent can fish produce architecture? This project sets out to trace a socioecological history of North Atlantic architecture in relation to fisheries, elucidating the relationships between marine environments and terrestrial landscapes and assessing the ecological impact of fishing constructions and the natural resources they depend upon. Fishing Architecture covers a broad spectrum in terms of both geography and time, a choice that was made to avoid deterministic analysis and engage with transnational phenomena. Thus, the focus is on the North Atlantic—its shores housing diverse architectural cultures and its waters home to a wealth of fish species—and follows a time frame that runs from the industrialization of fisheries in the early 19th century to the full globalization of the industry at the end of the 20th. The extant scholarship on marine ecology, fisheries, and fishing communities includes extensive research on fish populations, navigation systems, technology, bioeconomics, architecture, and cultural practices. Yet, comprehensive interdisciplinary analysis of the field is hindered by its own specialization. Facing the impending challenges of the environmental predicament, this project will use the material history of architecture as a powerful tool for advancing interdisciplinary research and, along with it, our understanding of the ecological impacts of human activity. The assessment will be organized along five analytical axes: (1) marine ecosystems; (2) fishing technology; (3) food processing; (4) politics; and (5) consumption habits, effectively avoiding the conventional architectural approach to understanding the built environment. This strategy allows us to identify critical knowledge gaps to be worked on and, most significantly, fosters a fresh perspective on construction in which fishing landscapes and buildings are understood as material traces of dynamic socioecological relationships and as part of the continuum between land and sea.

Keywords: architecture marine ecology fisheries sea land continuum ecosystems environmental history bioeconomics nature based solutions social ecological systems oceanography coastal communities
Autonomous Indoor Farming (AUTOFARM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 7648750.0
EU funding (EUR): 2500000.0
Participants: 2
Project status: CLOSED

AUTOFARM brings a disruptive and novel automated way of operating greenhouses to the market, applying a revolutionary new growing system that unlocks plant mobility for optimal use of robotisation and artificial intelligence. World-wide the high-tech indoor farm sector is expanding from 60k hectares to 80k in 2025. This growth is triggered by the societal need for climate resilient food production, the fast growing market demand for fresh food and the economic need for greater resource use efficiency. To enable this growth, many high-tech indoor farming processes have been standardised and optimised, but the automation of labour availability and crop management is lagging behind. SAIA introduces through AUTOFARM a paradigm shift towards a food factory of the future where 50% of the labour is automated and crop management is supported by data mining and artificial intelligence. SAIA’s novel plant system enables year-round steady production which allows for 30% more yield.
BEST AVAILABLE TECHNIQUES TO RECOVER OR RECYLE FERTILISING PRODUCTS FROM SECONDARY RAW MATERIALS (FertiCovery)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Coordination and support actions
Countries involved: Netherlands,Spain,Greece,Italy,Poland,Belgium,Germany
Call: Best available techniques to recover or recycle fertilising products from secondary raw materials (HORIZON-CL6-2024-ZEROPOLLUTION-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 2132259.11
EU funding (EUR): 1934961.38
Participants: 8
Project status: SIGNED

The main goal of the FertiCovery project is to analyse best available technologies for recycling fertilisers from secondary raw materials. It advises policymakers and stakeholders on alternative fertilising products, ensuring balanced nitrogen and phosphorus flows and promoting soil health and structure within ecological limits at regional and local levels. Starting from a long list of nutrient recovery (NR) and bio-based fertiliser (BBF) technologies, FertiCovery will select and describe ≥25 technologies, their feedstocks, products and applications, followed by a an assessment of technical aspects and environmental impacts of the technologies; an assessment of composition, sanitary safety and environmental impacts of the associated fertilising products; and an assessment of feedstock availability, potential for upscaling, regulatory framework, costs and social risks resulting in the market and replication potential. At the end of the project, a detailed multicriteria decision analysis report and datasheets of the 10-15 best available technologies will be available. The identification and engagement of European and international stakeholders, especially by organising 5 online/hybrid workshops and 6 physical/hybrid open forum events, will secure that information on best availability technologies is shared to a wider audience of technology providers, end users, policy makers and the scientific community. The project’s results will enable them to perform appropriate activities to removal of barriers and promoting the application of NR and BBF. This paves the way for widespread use of environmentally friendly BBFs. Society will benefit from the circular use of alternative fertilising products recovered from secondary raw materials, as they lead to lower environmental impacts on soil, water, and air quality, biodiversity and climate.

Keywords: recovery recycling bio based fertiliser best available technology techniques nutrient soil manure wastewater digestate soil environmental climate impacts farmer feedstock nitrogen phosphorus
Relations and Identities in a Saharan Environment (late third-tenth century CE) (RISE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

From the late 3rd to the 10th c. CE, Egypt transitioned from a Roman province to an Arab Muslim state. Despite much work, the societal and political changes in Egypt’s Western Desert oases (the Roman westernmost districts along the Libyan Sahara) remain poorly understood. RISE aims to fill this gap. By challenging the view of the oases as merely peripheral to the Nile Valley, RISE focuses on overlooked historical actors: the nomads in the Western Desert and their interactions with the oasis settlers. The working hypothesis is that these relations lie at the basis of the region's historical evolution. Nomads were often invisible, but in this transitional era, nomad-settler interactions evolved persistently, leaving records that let us trace them from the perspective of oasis settlers and in literary portrayals. Based on bibliographical data, RISE’s analysis is conducted on 2 corpora (100 documentary texts and 126 literary passages, respectively), including Greek, Latin, Coptic, Arabic texts, complemented by archaeological evidence. Combining expertise in the history of literature, papyrology, archaeology, and digital humanities, RISE adopts a socio-anthropological approach to interpreting socio-cultural dynamics. RISE is the first systematic study of nomad-settler interactions in Egypt’s Saharan frontier, late 3rd-10th. This broadens the debate on the oases, exploring an overlooked period and on nomad-settler relations in Rome’s Desert Frontier, including Egypt’s Saharan one. An international workshop (part of RISE) will foster a comparative discussion on Rome’s desert frontiers from Africa to the Levant. This interdisciplinarity needs a host like the UP1 - ArScAn unit, where I will be integrated and trained in digital humanities, archaeology, and papyrology, developing a distinctive expertise in Late Antique desert frontiers from a comparative view. New career opportunities in France and abroad will open. Dissemination will use various channels to maximase impact.

Keywords: late antique egypt early islamic egypt nomadic groups western desert of egypt desert frontiers
Respond to Emerging Dissensus: SuPranational Instruments and Norms of European democracy (RED-SPINEL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Belgium,Italy,Netherlands,Romania,France,Poland,United Kingdom,Hungary
Call: The future of liberal democracy in Europe (HORIZON-CL2-2021-DEMOCRACY-01, 2021)
Start date: 2022-09-01
End date: 2026-01-31
Duration (months): 41.0
Total project cost (EUR): 2975808.75
EU funding (EUR): 2969558.25
Participants: 11
Project status: SIGNED

RED-SPINEL stands for 'Respond to Emerging Dissensus: SuPranational Instruments and Norms of European democracy'. It is an interdisciplinary and intersectoral Research and Innovation Action bringing together 11 partner organisations from 8 European countries. It will jointly analyse the changing nature of dissensus surrounding liberal democracy and its implications for EU supranational policy instruments. RED-SPINEL will unpack the inter-connected drivers of contemporary dissensus surrounding liberal democracy. Its findings will be rooted in theoretical innovation and original empirical analyses. Its concept-building effort centered on the notion of 'dissensus' will explore how contemporary dissensus surrounding liberal democracy differs from previous debates and which more fundamental questions it raises about future democratic practices and the rule of law. Ultimately, RED-SPINEL will provide a typology of said dissensus, map the principal actors of the dissensus in Europe and unpack its two underlying drivers - i.e., heightened internal contestation over liberal democracy and external competition from alternative illiberal models. Empirically, RED-SPINEL will focus on the key policy instruments and legal mechanisms shaping the EU's efforts in support of democracy and the rule of law. The studied instruments include the EU rule of law toolbox, the neighborhood and accession instruments, the European semester, fundamental rights and judicial instruments, as well as citizen participation platforms. Furthermore, through a series of stakeholder events, RED-SPINEL will flesh out the implications of its findings for public policy stakeholders (i.e. legal professionals, policymakers, European youth) as well as EU instruments aimed at responding to said dissensus. The project will develop a range of scientifically informed policy recommendations and capacity-building efforts able to foster innovative democratic practices able to respond to the present-day dissensus.

Keywords: dissensus,eu policy instruments,rule of law toolbox,enlargement,european semester,counter majoritarian instruments,fundamental rights,liberal democracy,capacity building