Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Endoplasmic reticulum structure and synaptic function in Drosophila (SynapseER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2020-05-01
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

In neurons, endoplasmic reticulum (ER) organelle shows physical continuity between dendrites, cell body and axonal presynaptic terminals, and has been termed “a neuron within a neuron”. The importance of ER in axons is suggested by the fact that mutations of ER-shaping proteins result in hereditary spastic paraplegia (HSP), a motor axon degeneration disease. ER is present in presynapses, and mutations of ER-shaping proteins disrupt synaptic morphology or function. However, the physiological roles of ER distribution in this context are largely unknown. The time to study the roles of ER distribution in presynaptic terminals is opportune: new HSP-associated genes encoding ER proteins are being identified continuously in human patients; studies in non-neuronal cells identified several HSP-gene-encoded proteins as ER-shaping proteins - to date these have not been examined in synapses; there is increasing data about the nature and roles of contact sites between ER and other cellular structures, whose functions are required at synapses. Drosophila is a successfully used model for neuronal cell biology and degeneration, which reduces use of regulated vertebrates; my sponsor has developed tools to detect impaired neuronal ER organisation in Drosophila; and emerging microscopy techniques allow ultrastructural analysis and 3D reconstruction of the ER network. My work will specifically examine the distribution and role of ER at presynaptic level for the first time, and mechanisms of dysfunction that are relevant for human neurodegenerative diseases. I will study neuromuscular junctions in wild-type and in Drosophila mutants for HSP ER-shaping proteins, to understand the roles of these proteins and the consequences of any altered distribution for local trafficking and organelle function. To address this aim, I will use electron and super-resolution microscopy, and using light microscopy markers I will undertake structural and functional characterization of ER distribution.

Keywords: endoplasmic reticulum,hereditary spastic paraplegia,motor neuron,synapse,neuromuscular junction,drosophila
The political economy of management consulting firms in emerging economies: Evidence from illicit financial networks in Brazil and South Africa (MANAGECOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-01
End date: 2025-01-14
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

Over the last 10 years, cases of corruption and money laundering involving management consulting firms multiplied in the global South. They cast doubts on these firms’ claims to help establish transparent competitive economies and to deliver solid accounting services. MANAGECOR is a political science project which examines the role of these firms in the financialisation of emerging economies and their subsequent enabling of illicit financial flows. It looks at two cases (Petrobras and Odebrecht in Brasil, State capture case in South Africa) on which exceptional sets of data are publicly available but have not been used yet. The data are composed of political and judicial investigations which include leaks of internal documents with details of operations and services provided. They will be processed through an original interdisciplinary method and thanks to the trainings received by the researcher. The project aims at making 3 contributions: 1) Along with a group of leading researchers it will be associated with, it will develop a new theorization of corruption. It will show that corruption results of processes and networks of actors at the core of the global economy. These results may help to improve anti corruption policies. 2) The project uses a close collaboration with the supervisor and a joint discussion of the results to bridge gaps in the literature as regard to the accounting, fiscal and legal practices that consulting firms imported into emerging countries. It will examine how consulting firms act as brokers, how they manage their reputation and mitigate risks. 3) MANAGECOR contributes to rewriting the political economies of Brazil and South Africa to show how external reform agendas affected existing political economies of corruption. This will be done with the writing of a monograph and by engaging with local academics’ works. The results will be disseminated to a global public interested in understanding the perpetuation of structural inequalities.

Keywords: corruption,illicit financial flows,management consulting firms,development,brazil,south africa
Wireless Software and Hardware platforms for Flexible and Unified radio and network controL (WiSHFUL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Italy,Korea, Republic of,Belgium,Belgium,United States,Brazil
Call: FIRE+ (Future Internet Research & Experimentation) (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2018-04-30
Duration (months): 40.0
Total project cost (EUR): 5504304.58
EU funding (EUR): 5171000.0
Participants: 9
Project status: CLOSED

Wireless testbeds have become an essential tool to develop and validate innovative wireless solutions. However, due to the increasing diversity of wireless solutions and competing radio technologies, along with the ever more stringent requirements on the reliability of test results, wireless test facilities have evolved to very complex systems with steep learning curves for innovators. To speed up and facilitate the experimentation process, to lower its cost and to enhance the uptake of future non- and pre-standard solutions, the WiSHFUL project is determined to lower the experimentation threshold by developing flexible, scalable, open software architectures and programming interfaces for prototyping novel wireless solutions for a variety of applications ranging from healthcare to smart cities, supporting players in high value-add markets with considerable growth potential. Key features of WiSHFUL include (1) unified radio control, providing developers with deep control of physical and medium access components without requiring deep knowledge of the radio hardware platform and (2) unified network control allowing the rapid creation, modification, and prototyping of protocols across the entire stack. WiSHFUL will also create a testbed-on-the-move, consisting of portable facilities that can be deployed easily and efficiently at any location, allowing validation of innovative wireless solutions in the real world (with realistic propagation and interference characteristics) and involving real users. The usefulness of these facilities will be confirmed by participation of industrial and academic partners through open calls for experimentation. In addition, we envision to extend these facilities with the capability to experiment with emerging wireless technologies such as millimeter wave communications, full-duplex and massive MIMO in the scope of open calls for extensions.

Keywords: wireless facilities,radio hardware,radio control software,network control software,unified programming interface,testbed on the move
Realisation and Demonstration of Advanced Material Solutions for Sustainable and Efficient Ships (RAMSSES)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Countries involved: Germany,Germany,Germany,Italy,Germany,Spain,Germany,Germany,Germany,Estonia,Estonia,Italy,Finland,Greece,Finland,Croatia,Sweden,Sweden,Hungary,France,France,France,France,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Development, production and use of high performance and lightweight materials for vessels and equipment (H2020-MG-2016-Two-Stages, 2016)
Start date: 2017-06-01
End date: 2021-11-30
Duration (months): 54.0
Total project cost (EUR): 13494091.25
EU funding (EUR): 10799440.65
Participants: 44
Project status: SIGNED

The RAMSSES project has the strategic objective to obtain recognition and an established role for advanced materials in the European maritime industry. To achieve this the project will demonstrate the benefits of new materials in thirteen industry led and market driven demonstrator cases along the entire maritime process chain from components through equipment and ship integration to repair. Those demonstrators will reach a high Technology Readiness Level between TRL 6 and 8 and will either be installed on shore under close to reality conditions or validated on board. The technical performance as well as life cycle cost efficiency and environmental impact will be assessed and validated by specific expert teams following common procedures and testing standards. The test program will be based on risk assessment and a widest possible use of existing test results and supervised by rule making bodies, such ensuring relevance for a commercial approval beyond the project. Test data as well as best practice procedures on design, qualification and production of new material solutions will be made available in a maritime test database and a central knowledge repository, thus allowing fast qualification and approval of similar maritime applications in future. RAMSSES also aims to improve the innovation capabilities of the European maritime sector by elaborating terms of reference of a future use of the test database and the knowledge repository beyond the project. In cooperation with other initiatives, it will contribute to the formation of a maritime materials innovation Platform including continuous technology transfer from and to other industry sectors.

Keywords: advanced materials,long term testing,modularisation,standardisation,condition monitoring
Fast Assay for Pathogen Identification and Characterisation (FAPIC)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Belgium,Croatia,France,France,Netherlands,United Kingdom,United Kingdom
Call: Development of new diagnostic tools and technologies: in vitro devices, assays and platforms (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-05-01
End date: 2020-10-31
Duration (months): 66.0
Total project cost (EUR): 5999997.0
EU funding (EUR): 5999997.0
Participants: 11
Project status: CLOSED

The emergence of highly diverse resistance mechanisms among pathogens requires their detailed analysis to guarantee an efficient medical treatment. The gold standard in clinical diagnostics is based on the cultivation of bacteria and their phenotypical characterisation. However, these methods are labour-intensive and time-consuming lasting in some cases up to a few weeks. Thus, faster diagnostic techniques are necessary to ensure an immediate and targeted treatment of the patient. DNA-based diagnostics can provide the relevant results within a few hours. The requirements for a clinical DNA-based characterisation method are high; more than 1000 clinically relevant antibiotic resistance genes, a few hundred phylogenetic marker genes and virulence factors have to be targeted (including SNP detection). The limit of detection has to be low because a few 100 bacterial cells in the blood system can lead to the death of the patient. It should be possible to analyse a wide range of clinical sample origins such as stool, blood, urine and saliva using the same test. In addition, the results have to be obtained within a single working day. In our project, we will develop two diagnostic systems that can be with direct sample material from patients. Thus, the time-consuming cultivation of pathogens will be avoided. Additionally, the test will be more sensitive, specific and faster than any other test on the market using an innovative DNA probe concept.

Keywords: multiplex detection,microarray,dna isolation,pathogens,antibiotic resistance,diagnostic platform,virulence factors,bacteria,viruses,fungi
Role of dynamic JNK signalling in balancing cell removal and renewal in a stressed epithelium (JNK_Life.Death)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Tissue homeostasis requires a tight maintenance of cell number. Little is known about how tissue size and cell numbers are maintained in stress situations, when additional proliferation is needed to compensate for cell loss. I propose to study the homeostatic response to stress in a tissue (Drosophila wing primordia) in which Ribosomal Proteins-deficiency causes extensive apoptosis compensated by extra proliferation. How are these two responses balanced to ensure the emergence of a normal adult organism? JNK signalling is a strong candidate to mediate both apoptosis and proliferation responses. I propose to decipher the regulatory events that control this two-faced response, and to identify the proliferative pathways activated by JNK. Using the latest tools of genome engineering and live imaging, I aim at unravelling the spatio-temporal dynamics of JNK signalling and the downstream activation of cell death or division. Next, I will use a candidate gene and an unbiased approaches to uncover the transcriptional programs that correlate with apoptosis and proliferation. Lastly, I will verify the relevance of the identified candidates and investigate their spatial-temporal activity upon JNK activation. The results will be key to reaching the next stage of understanding the role of JNK in orchestrating the concerted replacement of lost cells that ultimately results in functional epithelia. Uncovering this logic in a relatively simple epithelium will hopefully guide further studies in more complex tissues of direct biomedical relevance.

Keywords: jnk signalling dynamics,stress response,compensatory proliferation,live imaging,transcriptomics
Visual Notify - Improving Deaf People's Life (Visualfy)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-03-01
End date: 2015-07-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Visualfy is developing a suite of smartphone Apps, through which it enables people with hearing deficiencies to more seamlessly interact with their environment. Visualfy’s current minimum viable product (MVP) allows Smartphone events, such as incoming (Video)-Calls, E-mail, and Whatsapp, to be linked to different screen-flash and vibration patterns, to notify a deaf person. Therewith, the MVP solves one of several key problems. Validation of the MVP is currently under way, with early positive responses reflected through currently 5000 customers, with around 200 new customers joining per week. It is clear that deafness can cause all kind of problems in daily life, like not being able to note alarm sounds, or simply problems with inter human communication. It is less well known that people with pre-lingual deafness (deafness before the acquisition of language) have difficulties to develop a spoken language and even to read and write, as these capabilities are tightly intervened with the formation of language (think of the spoken word forming in your brain while reading). According to the World Health Organization, partial hearing loss affects about 360 million people worldwide, 0.1% being pre-lingual. Considering at the same time a dramatically growing Smartphone penetration, even in poorer societies, establishes a growing market environment. Initial sales of the MVP are qualitatively validating one key customer problem, and the market seems ripe for disruptive innovation, allowing the introduction of Visualfy’s Smart Space Concepts to “Improve Deaf People’s Life”.

Keywords: smartphone app,mobile applications,hearing deficiencies,deafness,pre lingual,sign language,cochlear implants,social for profit,smart space,internet of things,disruption
On-line Dialysis Sensor Phase2 (OLDIAS2)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Estonia
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-08-01
End date: 2019-10-31
Duration (months): 27.0
Total project cost (EUR): 2823952.0
EU funding (EUR): 2823952.0
Participants: 1
Project status: CLOSED

End-stage renal disease (ESRD) is the most severe form of chronic kidney disease that is an incurable health failure. ESRD is a widespread health issue in developed countries and the patients have only two options: either receive permanent renal replacement therapy or undergo surgery to receive a kidney transplant. There are approximately 3.4 million patients worldwide suffering from ESRD that need artificial methods to replace regular kidney functions in their organism. Currently there are no technologies available that would give adequate feedback in real-time on all the important parameters of treatment quality. Optofluid Technologies (OFT) has set out to introduce an online dialysis monitor that utilizes optical techniques. It has developed a prototype that is able to measure all the important uremic biomarker groups in order to provide detailed feedback on the treatment efficiency. A successful SMEI P1 project has been implemented to carry out a detailed feasibility study and OFT is ready to finalize the development in order to bring the novel device to the market. In order to accomplish this OFT is looking to validate the product performance in clinical setting. To ensure the success of the development EU leading hospitals from 5 different member states have been included to carry out the clinical studies. In addition, the leading experts on uremic biomarkers from the EUTox working group will be involved to ensure effective commercialization and communication activities looking to achieve a fast and widespread market acceptance. The planned project will have a wide-spread economic and social impact by influencing all the key stakeholders – scientific and medical community, patients and dialysis equipment manufacturers. As a result of the development project, OFT will generate revenues of up to 73MEUR by 2023.

Keywords: uremic biomarkers,medical device,monitoring device,dialysis,renal therapy,end stage renal disease,online monitoring,uv technology
HYBRID PHOTOVOLTAICS FOR EFFICIENCY RECORD USING INTEGRATED OPTICAL TECHNOLOGY (HIPERION)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Spain,Spain,Ireland,Ireland,Germany,Switzerland,Belgium,Poland,Switzerland,Switzerland,France,France,Czechia,United Kingdom,Portugal
Call: Increase the competitiveness of the EU PV manufacturing industry (H2020-LC-SC3-2019-RES-IA-CSA, 2019)
Start date: 2019-09-01
End date: 2023-08-31
Duration (months): 48.0
Total project cost (EUR): 13373471.78
EU funding (EUR): 10590511.26
Participants: 17
Project status: SIGNED

The HIPERION consortium has been assembled to answer the call LC-SC3-RES-15-2019: Increase the competitiveness of the EU PV manufacturing industry. The goal of the project is to bring to fruition at the industrial scale a validated high efficiency module-level innovation, based on a disruptive planar optical micro-tracking technology, which concentrates sunlight on multijunction solar cells, mounted on top of a conventional silicon backplate. The resulting high efficiency solar modules (>30% STC under direct sunlight) with a standard flat panel form factor can be mounted on any standard racks or rooftops. The technology has been extensively demonstrated with outdoor tests and pilot installations. It must be now industrialized for mass production, to enable its integration by manufacturers in their existing production lines. The project will demonstrate at pilot-line level the assembly of these high efficiency modules, while several commercial pilot sites across Europe and qualification tests will further validate the performance and reliability. To achieve successfully this 48-month, 13 M€ valued action, a consortium of 16 members representing 9 European countries has been gathered. It includes several industrial players with the key expertise to develop the assembly processes, and some of the most renown European PV centers with strong know-how on design and qualification. A solar manufacturer will do a detailed economical evaluation on the integration of the technology in the production line, while several solar installers will represent both the rooftop and utility end markets. With its novel module architecture and innovative manufacturing processes, HIPERION has the potential to drastically reduce solar electricity costs by significantly boosting the efficiency. It could allow EU PV manufacturers to gain a clear competitive advantage against mainstream solar modules and to regain market shares on the growing PV market.

Keywords: optical micro tracking solar cells,multijunction solar cells,efficiency rating 30,pilot production line,demosites