Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Identification of the role of autophagy during fruit ripening and stress resistance in Strawberry: Autophagy manipulation as a way to improve Strawberry fitness (FrATGaria)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-04
End date: 2021-10-02
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Autophagy, the major catabolic pathway in eukaryotic cells, has a role in the resistance to biotic and abiotic stresses in different plant species. Plenty of studies show that blocking autophagy by knocking out some of its essential genes leads to plants highly susceptible to this stresses (including heat and drought). However, there are much less studies about the effect of autophagy induction on the response of plants to stresses. Present situation of global warming is already having an effect in agriculture due to a rise in temperature and to water shortages. Therefore, generation of crops with higher resistance to heat and drought should be a priority nowadays. In this proposal I will study the role of autophagy in the maturation of one of the most important berry fruit in EU, Strawberry (Fragaria x ananassa). I will determine the importance of this catabolic process in the response to heat/drought stress in this crop. Furthermore, I will use the diploid strawberry model specie Fragaria vesca to generate transgenic plants with increased autophagy by CRISPR/Cas9 and CRISPR/dCas9 genome editing and analyze the potential benefits regarding general development, fruit quality and stress resistance (this previously shown for Arabidopsis, tomato and apple) that this plants can have compare to wild type. This will be the first basic and applied study of autophagy in strawberry. "FrATGaria" will combine my experience in the autophagy field with the expertise of the host group in strawberry development and fruit ripening and will benefit from active collaboration with strawberry breeding groups. The development of this project will allow me to broaden my knowledge about plant development in response to stress strengthening not only my scientific skills but also my leadership, project managment and mentoring capabilities.

Keywords: autophagy,abiotic stress,fragaria,fruit ripening,plant fitness
Porto Energy ElevatoR (PEER)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Portugal,Portugal,Portugal
Call: Aggregation - Project Development Assistance (H2020-LC-SC3-EE-2020-2, 2020)
Start date: 2021-06-01
End date: 2024-05-31
Duration (months): 36.0
Total project cost (EUR): 856887.5
EU funding (EUR): 856887.5
Participants: 4
Project status: SIGNED

The purpose of “PEER” is to develop the Porto Energy Hub that will support a novel renovation programme in the north of Douro river region of Porto Metropolitan Area, AMP-ND (Portugal) aiming to fight energy poverty by promoting buildings energy efficiency, renewable self-consumption energy communities and mainstreaming new financial schemes. PEER will develop integrated tools to overcome market barriers for social and low income households energy efficiency (while promoting energy communities) PEER will: 1. Focus on delivering energy efficiency to improve housing conditions in AMP-ND namely on the interventions on reducing building energy needs, such as envelope insulation, efficient windows and doors, lighting, efficient heating and cooling systems, etc. as means to mitigate the impact of energy poverty; 2. Include renewable energy as an add-on to energy efficiency namely by the development of energy communities that allow the development of production units for self-consumption; 3. Mainstream alternative financial schemes and business models by combining existing funding sources and innovative financing schemes. All actions will be supported by capacity building, communication and dissemination activities targeted to the various stakeholders, namely low-income homeowners, public and private building owners, project developers, ESCO and financial institutions. Porto Energy Hub will leverage EUR 27,2 million of investment covering 3,000 households in the region and leading to 71 GWh/year and 17 GWh/year of primary energy savings and renewable energy production respectively. In a nutshell, the Porto Energy Hub will act as a one-stop-shop to public and private building owners, promoting aggregation to develop a bold renovation programme of their buildings and combine them with alternative financial schemes and legal models.

Keywords: energy efficiency,energy poverty,renewable energy,energy hub
Genetically encoded sensors for imaging neurochemical dynamics in vivo (OPTONEUROCHEM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1498750.0
EU funding (EUR): 1498750.0
Participants: 1
Project status: SIGNED

How specific neurochemicals (neurotransmitters, neuropeptides and hormones) influence our mental states and behaviors remains one of the biggest questions in biology. So far, we largely lack tools to precisely monitor the temporal and spatial profile of neurochemical signaling in behaving animals. The ability to do this is a prerequisite for understanding the critical functions of these molecules in both health and disease. OPTONEUROCHEM is a bold and transformative project that will develop a new breed of genetically encoded sensors to enable real-time and highly-specific functional imaging of neurochemicals at unprecedented resolution in awake behaving animals. This project is geared towards creating innovative tools that will transform the current biotechnological landscape. I will first engineer novel red-shifted sensors for monoamines and apply them in multiplex and optoacoustic imaging experiments (Objective 1). I will then develop sensors for neuropeptides based on previously unexplored receptor subtypes. These will be validated in increasingly complex biological systems and utilized for monitoring the task-specific dynamics of endogenous neuropeptides in multiple brain regions of awake behaving mice (Objective 2). Finally, I will leverage on novel protein scaffolds to engineer the first ultrasensitive probes for steroid hormones and explore their application to in vivo imaging (Objective 3). This high-risk high-reward project combines state-of-the-art cross-disciplinary techniques, ranging from protein engineering and optogenetics, to animal behavior, and in vivo fluorescence and optoacoustic imaging. Together, the next generation tools I plan to develop will revolutionize our approach to study neurochemical activity in living animals. Ultimately, these tools will advance our understanding of brain function in health and disease.

Keywords: fluorescent proteins,chemical signaling,receptors,bioimaging
Universal microwave photonics programmable processor for seamlessly interfacing wireless and optical ICT systems (UMWP-CHIP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-07-01
End date: 2022-12-31
Duration (months): 66.0
Total project cost (EUR): 2494444.0
EU funding (EUR): 2494444.0
Participants: 1
Project status: CLOSED

Information and communication technology (ICT) systems are expanding at an awesome pace in terms of capacity demand, number of connected end-users and required infrastructure. To cope with these rapidly increasing growth rates there is a need for a flexible, scalable and future-proof solution for seamlessly interfacing the wireless and photonic segments of communication networks. RF or Microwave photonics (MWP), is the best positioned technology to provide the required flexible, adaptive and future-proof physical layer with unrivalled characteristics. Its widespread use is however limited by the high-cost, non-compact and heavy nature of its systems. Integrated Microwave Photonics (IMWP) targets the incorporation of MWP functionalities in photonic chips to obtain cost-effective and reduced space, weight and power consumption systems. IMWP has demonstrated some functionalities in through application specific photonic circuits (ASPICs), yielding almost as many technologies as applications and preventing cost-effective industrial manufacturing processes. A radically different approach is based on a universal or general-purpose programmable photonic integrated circuit (PIC) capable of performing with the same hardware architecture the main required functionalities. The aim of this project is the design, implementation and validation of such processor based on the novel concept of photonic waveguide mesh optical core and its integration in a Silicon Photonics chip. Its three specific objectives are: (1) The architecture design and optimization of a technology-agnostic universal MWP programmable signal processor, (2) The chip mask design, fabrication and testing of the processor and (3) The experimental demonstration and validation of the processor. Targeting record values in bandwidth and footprint its potential impact will be very large by unlocking bandwidth bottlenecks and providing seamless interfacing of the fiber and wireless segments in future ICT systems.

Keywords: integrated optics,microwave photonics,fiber wireless systems,optical microprocessors
Generation of the CanPath prototype - a platform for predictive cancer pathway modeling (CanPathPro)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Germany,Norway,Switzerland,France,France,Netherlands
Call: New bioinformatics approaches in service of biotechnology (H2020-LEIT-BIO-2015-1, 2015)
Start date: 2016-03-01
End date: 2021-11-30
Duration (months): 69.0
Total project cost (EUR): 10713058.48
EU funding (EUR): 9862545.98
Participants: 10
Project status: CLOSED

Recent developments in omics technologies demand implementation of systems biology approaches to facilitate analysis and interpretation of the generated complex datasets.This is essential for biotechnological as well as preclinical and clinical applications. In comparison to previous approaches, most cancer relevant studies are confined to pattern recognition or at best modelling of single pathways, rather than the complex pathways and cross-talk determining cancer progression and drug response. Systematic tools that evaluate and validate personalised medicine approaches on a preclinical level are missing; an important prerequisite for translation into clinical practice. The overall objective of CanPathPro is to build and validate a new biotechnological application: a combined experimental and systems biology platform, which will be utilized in testing cancer signaling hypotheses in biomedical research and life sciences. Thus, the proposed project will focus on developing and refining bioinformatic and experimental tools for the evaluation of systems biology modelling predictions. Components comprise a highly controlled mouse experimental system, NGS, a quantitative proteomics based read-out of changes in pathway signalling and an integrative systems biology model for data integration. Testable hypotheses about biological systems will be generated and experimentally validated. The developed system tools will be made available to researchers, SMEs and industry for practical applications. Following this project, a commercial platform for interpretation and analysis of complex omics data and for deriving and testing new hypotheses will be set up by the participating companies and academic partners. CanPathPro will enhance the competitive potential of the SMEs involved expanding in the field of biotechnology, personalised medicine and drug development and also provide new opportunities for other SMEs working in the field of bioinformatics and biomedical applications.

Keywords: omics,cancer,systems biology,computational modelling,data integration,mouse models,disease signalling,proteomics,next generation sequencing,genomics
Optimised moulded pulp for renewable packaging solutions (PULPACKTION)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Innovation actions
Partnership: BBI (Art-187)
Countries involved: Spain,Italy,Germany,Spain,Norway,Sweden,Sweden,Sweden,Croatia,Netherlands,Netherlands
Call: Innovative cellulose-based composite packaging solutions (H2020-BBI-PPP-2015-2-1, 2015)
Start date: 2016-10-01
End date: 2021-09-30
Duration (months): 60.0
Total project cost (EUR): 11166442.88
EU funding (EUR): 8303374.05
Participants: 15
Project status: CLOSED

The aim of PULPACKTION project is to develop cellulose-based tailored-to-purpose packaging solutions for specific food and electronic packaging applications which needs medium and high barrier requirement’s and that nowadays are packing in polymer fossil based solutions. This innovation will take advantage of the flexibility in the wet-moulding production of wood pulp based materials. Different types of wood pulp will be combined to prepare slurries for wet-moulding applications. These slurries will be additivated with biopolymers and other bio-based compounds in order to tailor the final properties of the resulting wet-moulded materials. By tailoring the composition of the wet mouldable slurry, a wide range of final properties in the resulting dry material will be achieved. This flexible packaging manufacturing system will be combined with 100% bio-based coatings and films on the cellulose-based substrate. To fulfil the properties required for PULPACKTION’s specific packaging applications using a fully bio-based approach, additional barriers will be implemented onto the wet moulded substrate. For this purpose, new bio-based polymer blends will be optimized. These new blends, containing biopolymers such as thermoplastic starch (TPS), poly (lactic acid) (PLA), other bio-additives, and reinforcements such as microfibrillated cellulose (MFC), will be processed into multilayer films, composites and coatings. In this manner, not only coatings for improved barrier properties, but also 100% bio-based films for packages’ top lids will be produced. Therefore, a final 100% bio-biobased integral packaging solution with similar properties to existing fossil-based packaging solutions will be achieved.

Keywords: bio based packaging,pulp wet moulded,cellulose based,rural development
All Solid-sTate Reliable BATtery for 2025 (ASTRABAT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Germany,Spain,Ukraine,Germany,Spain,Poland,Belgium,Slovenia,France,France,France,France
Call: Strongly improved, highly performant and safe all solid state batteries for electric vehicles (RIA) (H2020-LC-BAT-2019, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 7817568.75
EU funding (EUR): 7817568.75
Participants: 16
Project status: SIGNED

Europe is facing a major challenge to develop and produce a competitive Li-battery product in order to avoid dependency on third countries in its energy transition models. The Li-ion cell innovations should meet specific technical and economical requirements to sustain the market growth. The all-solid Li-ion technology appears to be one of the relevant options but it still has to be brought to higher TRL to be economically and environmentally friendly for a mass production compatible process. The ASTRABAT project gathers 14 partners, leaders in the different fields of research, development and production, from 8 countries. It aims to find optimal solid-state cell materials, components and architecture that are well suited to the demands of the electric vehicle market and compatible with mass production. The project will comply with improved safety demands and industrial standards. Five ambitious objectives were defined: 1. Development of materials for a solid hybrid electrolyte and electrodes enabling high energy, high voltage and reliable all-solid-state Li-ion cells 2. Gen#2D cell design: processing techniques compatible with existing routes of large scale cell manufacturing (10Ah, Energy type) and validation of a pilot prototype in a relevant industrial environment 3. Development of a 2030s eco-designed generation for Power-type and Energy type all-solid-state cells in pre-prototype (Gen#3DS and #3DC) 4. Define an efficient cell architecture to comply with improved safety demands 5. Structuration of the whole value chain of the all-solid-state battery, including eco-design, end of life and recycling The project will reinforce the European battery value chain, strengthen collaborations between RTOs, SMEs and Industrial partners from material development to integration in vehicles. The implementation of related work packages, tasks, milestones and risk assessment is considered to achieve these objectives comprehensively.

Keywords: li ion battery,all solid state electrolyte,ni rich nmc
Virtual eye model system for personalised refractive surgery treatment (VEMoS)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Spain,Italy,Portugal,Denmark
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2019)
Start date: 2019-12-01
End date: 2023-09-30
Duration (months): 46.0
Total project cost (EUR): 3935335.4
EU funding (EUR): 2997269.0300000003
Participants: 7
Project status: SIGNED

The incidence of myopia is predicted to rise from 28% of the global population in 2010 to almost 50% in 2050. Factors such as population aging and increase of hours spent in front of screens are driving the increase in global eye deficits. Vision impairments reduce the quality of life, affect economic and educational opportunities and increase the risk of death. This is particularly important for vulnerable groups such as elderly, children, workers and drivers. Overall, WHO reported that uncorrected vision was responsible for €241bn of productivity loss per year worldwide. Our innovative Virtual Eye Model System (VEMoS) is based on patented revolutionary ophthalmic diagnostic devices (CSO’s MS-39 tomographer/topographer and the unique open-field aberrometer), as well as on innovative simulation software developed by Vissum. Overall, our innovation provides personalised clinical-decision support based on each patient’s eye measurements and neural network simulations of post-surgery outcomes, improving surgery success and patient satisfaction rates. By combining CSO’s ophthalmic high-tech hardware design, manufacturing and commercialisation skills with Vissum’s refractive surgery and software development and independent clinical testing by CHUC and AUH, this project is expected to bring economic, social and health impacts, including progress towards achieving the EC action plan on personalised medicine “ICPerMed”. Our goal is to mature, scale-up and demonstrate the production of the VEMoS system, targeting ophthalmology clinics as clients, and with the aim to standardise refractive surgery decision making and revolutionise the refractive surgery field with personalised treatments. A successful VEMoS project will allow us to create measurable impacts on our companies, quantified as accumulated revenue of €145.3m in five years (2022-2026), equal to accumulated operating profit of €58.2m, creating 60 full time employments, and generating €37m in reduced customer costs.

Keywords: open field aberrometer,topographer,tomographer,corneal and ocular wavefront,neural network,post operative simulation,refractive surgery,lasik,smile,monofocal and multifocal intraocular lenses
The Enterprise Europe Network Baden-Wuerttemberg - Targeting Innovation from Baden- Württemberg for Europe (BW-KAM 5)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Germany,Germany,Germany,Germany,Germany,Germany
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 467010.0
EU funding (EUR): 467010.0
Participants: 10
Project status: CLOSED

BW-KAM 5 will implement tested and tailored innovation management services and tools to enhance innovation management capacities in Baden-Württemberg's (Germany) SMEs that have the potential to grow and internationalise. The services will be adapted to the needs of the SMEs and also market requirements in order to provide innovative products and services to Europe’s markets. Key Account Management will be provided to SME beneficiaries from the EIC pilot by identifying and matching SME owners with coaches and investors in order to bridge knowledge gaps or financial requirements. The region covered is Baden-Württemberg in southwest Germany, which has been served by the Enterprise Europe Network Baden-Württemberg consortium for the last ten years.

Keywords: innovation management