Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
More specific insecticides: harnessing knowledge of insect receptors (LessToxCites)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-06-01
End date: 2024-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Pest control is a central component of agriculture. However, insecticides and agriculture can have an impact on ecosystems. Regulations have been taken in Europe to ban some insecticides, based on the possible threat they pose to pollinators. There is an urgent, unmet need for species-specific insecticides that are safe for non-target organisms. In the proposed proof-of-concept project, we aim at demonstrating that peptides specifically designed against neurotransmitter receptors can be potent at pest species without affecting beneficial species. During the previous ERC-StG project, we developed tools to obtain pure mammalian neurotransmitter receptors. We have adapted those tools for insect receptors, which are the most important insecticide targets. We here propose to use insect receptors for the selection of species-specific peptides. The peptide libraries will be designed by computational-guided mutagenesis and screened by yeast display. Within the project, we aim to secure a solid IP position on the technology platform we will build, in order to maximise the likelihood of success for a commercial endeavour. We will explore the market opportunity and regulatory pathway for subsequent product development, in order to define a business model and implement early commercialisation steps.
Multi-Scale Amplitudes For Collider Physics (MultiScaleAmp)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1492250.0
EU funding (EUR): 1492250.0
Participants: 2
Project status: SIGNED

The large amount of data that will be collected by experiments at the Large Hadron Collider in the coming years will lead to an unprecedented increase in the precision of their measurements. To benefit from these precise measurements and improve our understanding of the fundamental laws of physics, we must obtain a broad set of theoretical predictions to corresponding levels of precision. Crucially, these predictions require the computation of multi-particle multi-scale two-loop scattering amplitudes involving massive particles. This poses a formidable challenge that we are currently unable to meet. In recent years, a new framework for the calculation of amplitudes has begun to emerge. Building on a deep understanding of the physical and mathematical properties of the amplitudes, it uses numerical evaluations to constrain an Ansatz for the analytic form of the amplitude. Working in this framework, MultiScaleAmp will redefine the state of the art in multi-scale two-loop amplitude calculation by singling out the main bottlenecks in current approaches. In particular, it will make use of geometric and mathematical tools to understand the analytic structures which underpin the amplitudes, and introduce techniques which can handle a number of scales beyond the reach of current approaches. This will lead to a wide set of two-loop amplitude calculations, triggering a new era of theoretical precision. In summary, MultiScaleAmp will make revolutionary conceptual developments in multi-scale amplitude computations, and usher in a new era of precision at hadron colliders. It will deliver: 1. Novel approaches for the computation of multi-scale Feynman integrals. 2. New techniques for the computation of two-loop amplitudes with many scales. 3. The necessary two-loop amplitudes for the production at hadron colliders of jets in association with heavy particles such as Higgs bosons, top quarks or vectors bosons.

Keywords: scattering amplitudes,qcd,multi loop,nnlo,higher order corrections,feynman integrals
Deployment of ModelMe Innovation (ModelMe)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Germany
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-01-31
Duration (months): 7.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

The primary objective of the work performed within the proposed project is to bring our innovation to the point at which it can be successfully disseminated and exploited through a product launch. Our technical progress so far has been a result of R&D breakthroughs over the last 18 months (since July 2021) by our team of four. We consider the following tasks/actions necessary to reaching our main objective: pre launch product and design validation; iteration on user interface design, iteration on innovation, business model & go to market revision; and deployment of our technology via a web based application. Product validation includes the rigorous interviewing of existing partners and potential clients on the topic of ModelMe's technical capabilities and the design of our user interface. Our interviews will be conducted through video calls, on-site visits and through surveys. The relevance of product validation ensures that after launch, customers can intuitively use the product and want to pay for it. Business model and go to market revisions will be made prior to the launch to ensure relevancy to the current market conditions. In addition, product and marketing material will be created for customer acquisition and product onboarding. Lastly, upon successful iterations of the innovation and user interface design, we shall build and deploy a scalable web based product which will enable our customers to access our deep tech algorithms for use. Grant resources will be channeled towards each of the tasks mentioned above.

Keywords: artificial intelligence ai
Autonomous Robots with Common Sense (ARCS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-07-01
End date: 2029-06-30
Duration (months): 60.0
Total project cost (EUR): 1996040.0
EU funding (EUR): 1996040.0
Participants: 1
Project status: SIGNED

Autonomous robots such as autonomous vehicles cars and drones have the potential to revolutionize the way we work and live. Unfortunately, current autonomous robots do not have ‘common sense’ and may enter a catastrophic condition called loss-of-control after failures. The ultimate goal of this research is to enable a new generation of autonomous robots that are aware of their physical capabilities and limitations, allowing them to act with common sense after failures. To achieve this I propose a new paradigm in autonomous robot control: ‘Artificial Physical Awareness’ (APA). APA requires accurate real-time knowledge of the time-varying stochastic safe envelope which is a subset of the state-space inside which safe operations of the autonomous robot can be guaranteed. The safe envelope is stochastic and time-varying; it contains uncertainties and will shrink after failures, reflecting the reduced post-failure performance of the autonomous robot. Obtaining and utilizing the time-varying stochastic safe envelope in real-time represents a currently unsolved scientific challenge for the following reasons: 1) the safe envelope cannot be measured directly; 2) current safe envelope computation methods are real-time intractable and/or do not take into account uncertainties; and 3) no control methodology exists that allows for time-varying safe-envelope informed balancing of safety and performance. This multidisciplinary research combines new insights in time-varying stochastic state reachability analysis, tipping-point forecasting, bio-inspired envelope sensing and recovery, and nonlinear fault-tolerant control to develop the new APA-autopilot system, which is the main output of this research. This research project has the potential to lead to a revolution in autonomous robot design, and operations by providing transparent safety and performance bounds, even after failures.

Keywords: safe autonomy,aerial robotics,bio inspired robotics
SHAring Researchers’ Passion for Enhanced Roadmaps - The European Researchers’ Night in Italy 2022-2023 (SHARPER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Italy
Call: European Researchers' Night 2022-2023 (HORIZON-MSCA-2022-CITIZENS-01, 2022)
Start date: 2022-04-01
End date: 2024-01-31
Duration (months): 22.0
Total project cost (EUR): 982000.0
EU funding (EUR): 982000.0
Participants: 9
Project status: CLOSED

SHARPER brings together young generations, citizens, and researchers to develop roadmaps to a better and desirable future. Researchers are passionate about future, and they constantly design, adapt and implement roadmaps to contribute to build it. This process increasingly involves young generations and citizens at large and make researchers and citizens “travel mates”. Curiosity driven choices and social needs together mould researchers’ agendas and generate roadmaps that need to be constantly enhanced to effectively tackle new challenges. Researchers are increasingly at the heart of this process and the acronym SHARPER – SHAring Researchers’ Passion for Enhanced Roadmaps describes their attitude to constantly evolve action plans to be key players within the society. SHARPER 2022 and 2023 will let citizens and researchers share this endeavour through engaging activities focused on the 5 missions of the Horizon Europe work programme. SHARPER involves 14 cities in 8 regions across Italy: Ancona, Camerino, Cagliari, Catania, Genoa, Macerata, L'Aquila, Nuoro, Palermo, Pavia, Perugia, Sassari, Terni and Trieste through a diverse network of 9 consortium partners including Universities, Research Institutions, Museums, Social Enterprises and more than 200 stakeholders from the civil society, the cultural creative world, industry, research and education. A special collaboration is developed with the Education National System through association of teachers and regional educational offices. The project will consolidate and innovate the experience developed over the last 9 years triggering researchers’ and citizens’ engagement across Italy. SHARPER has a solid European dimension through a collaboration with 7 ERNs in 7 countries to develop creative online contents and formats, common strategies on impact assessment and researchers’ trainings. SHARPER also collaborates with other Nights in Italy to share ideas, communication and awareness actions.

Keywords: ern,passion,marathon,researchers,excellence,cities,schools,fun,steam,online he missions,innovation,education,green deal,entertainment,humanities,science,performances,night
Technological assessment of Mesolithic portable art in Norway and Ukraine via submillimetre 3D modelling (TEMPA-3D)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway,United Kingdom
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 2
Project status: SIGNED

TEMPA-3D offers a transdisciplinary approach to study endangered archaeological collections from Kamyana Mohyla, Ukraine and Rogaland, Norway. By fusing photogrammetry and experimental archaeology TEMPA-3D will initiate new research subfield and make an impact on the broader discourse about Mesolithic portable art. The study addresses the lack of targeted investigations of how the engraved ornaments were made, and moves beyond state-of-the-art by developing a method for linking specific surface modifications to particular engraving techniques. By attending art as a process of making, this project will contribute to our understanding of the complex nature of human craft-making and creativity – a topical subject in present society. The main objective is to assess the engraving techniques used for producing the Mesolithic portable art. The chosen case studies, each representing late Mesolithic fishing societies, reveal similarities and variation in art-making technologies and symbolic expressions during the 8-4th millennium BC. Through its innovative methodology, TEMPA-3D will analyse and contextualise 60 engraved sand- and soapstone artefacts. Through a three-stage process it will develop a fluent workflow augmenting the information that can be obtained about the engravings: 1) Artefacts’ individual biographies will be analysed by means of recent advancements in photogrammetric submillimetre 3D modelling, developed and patented by the PF. 2) A dataset that links specific engraving features to particular techniques will be obtained through actualistic experiments. 10 experimentally made replicas will be produced and 3D modelled. 3) To interpret the techniques that were employed by the prehistoric crafters, archaeological and experimental 3D datasets will be compared. The outcome of this multi-analytic study will be an open access high-resolution digital 3D catalogue and a visual referential database, for the benefit of the archaeological community and future research

Keywords: prehistoric art archaeology experimental archaeology photogrammetry for cultural heritage mesolithic
Fatty liver versus autoimmunity of the bile ducts - defining the gut signals driving steatosis and inflammatory disease of the gut-liver axis (FatVersusBile)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Norway
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: SIGNED

The obesity epidemic has caused a surge of metabolic-dysfunction associated steatotic liver disease (MASLD), an important cause of morbidity and mortality. This also leads to other liver diseases presenting with steatotic (fatty) liver as a “second hit”, with unpredictable impact on clinical outcome. In the present project, I will use the co-existence of two different liver diseases to study how the gut microbiome interacts with steatosis and autoimmunity. Both MASLD and primary sclerosing cholangitis (PSC), an autoimmune disease of the bile ducts, are more common in inflammatory bowel disease (IBD) than in the population, suggesting they are driven by gut microbial activity (gut signals). However, MASLD and PSC co-exist less frequently than expected, appearing to protect against each other. Separate gut signals could therefore influence these conditions, and a driver of one disease could even protect against the other. Studies of PSC-MASLD-IBD provide a unique window to define how gut signals interact to cause and drive liver health, which would be of great importance in MASLD and PSC, where few effective therapies are available. I have in the ongoing ERC Starting Grant StopAutoimmunity shown that PSC is associated with large changes in microbial functions, motivating the novel hypothesis that distinct gut-derived signals drive autoimmunity of the bile ducts and steatotic liver disease. I will use an extensive set of methods established in my group to define the gut signals acting in PSC and MASLD and liver health. I have available unique cohorts and materials from these conditions, and experimental models based on human microbiome. The expected outcomes include the first detailed description of this clinical problem and the identification of distinct gut signals driving and protecting against steatosis and biliary autoimmunity, serving as basis for diagnostic and prognostic tools, and new targets relevant for trials to prevent and treat liver disease.
Human-centric, AI-generated Factory Training (AI-Factory-Training)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: SIGNED

Why? Augmented Industries is on a mission to accelerate the human-centric, digital, and sustainable transformation of the European manufacturing industry with scalable, AI-generated, and science-based learning in the flow of factory work. This is crucial, since current training solutions are often too costly and inaccessible for factory employees. We thus boost both employee engagement and operational excellence. By 2030, we strive to become the world’s leading AI-enabled factory training provider, reaching 1 million factory employees. What? We offer a novel solution that uses AI to transform existing factory documentation (e.g. work instructions), into interactive learning nuggets, which are delivered through a factory-proven interface, as engaging as Duolingo. How? We successfully bootstrapped the technology to TRL 6 and demonstrated excellent results in a factory-wide pilot at a Siemens electronics plant, such as 87.5% reduction in the training creation time, 29.3% higher learning effectiveness, and 91.3% employee satisfaction. We now plan to advance our human-centric generative AI training creator to TRL 8. To date, we could secure support from leading incubators in Munich, such as Xpreneurs and Tech Founders. Who? The company is led by a strong team of founders, Dr Elisa Roth (CEO) and Dr. Mirco Moencks (CTO) holding PhDs in Engineering from the University of Cambridge and experience in leading manufacturing and consulting companies, such as Bosch, Audi, and McKinsey. Key managers have more than 10 years expertise in full stack development, generative AI, and enterprise software. Our senior advisors come from BMW and Siemens. Ask: We now apply for grant-only funding of EUR 1.5 million from the EIC Accelerator to scale an excellent developer team, finance product development until TRL8, and certifications (e.g. ISO27001). Despite some initial angel investments (150k), we could not secure further investment through the remaining development risk.

Keywords: human centric generative ai,manufacturing training,upskilling,reskilling
Biomimetic Unmanned Flying Van (FLYING ROBOTS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 4000000.0
EU funding (EUR): 4000000.0
Participants: 1
Project status: SIGNED

At Flying-Robots, we believe that all communities in the world should benefit from the logistics connections necessary for their needs, their development and prosperity. Whether ground connections are complicated, risky, or simply saturated, countless supply needs must be met. But only under 3 conditions : the shipment has to be reliable, at the lowest possible cost, and with minimal impact on the environment. And it is precisely by observing the nature for more than 10 years, especially eagles able to carry preys equivalent to their own weight while flying, that our team has developed a unique aircraft in the world, whose large cargo capacities and tremendous energy efficiency bring the Distributed Logistics industry a revolutionary solution to face those challenges. In a global context where logistics needs are constantly growing and struggling to be met, especially in large areas where land-based means are complicated or risky, solutions are missing to replace current airborne shipping, which are too costly and CO2-emission intensive. How to carry the maximum load, while spending as little energy as possible? By mimicking the extraordinary abilities of eagles. This has been the guideline of the V2 project launched on 2022 with the objective to create a robust Flying Van designed for heavy load, long range and endurance handling, operating at lower cost and lower carbon emissions than any other capacity-similar aerial vehicles. The V2 project leverages the cumulative experience of the V1 product that was conducted in the 2000's. Therefore our current project doesn't start from scratch, it starts from a proven concept instead. The use cases covered are in Logistics (#1 market in volume and growth) and Surveillance (#2 market) areas where we intent to take a 2,5-3% worldwide market share in 2030. We are looking for EIC to help us at financing the R&D completion of our product V2 whose commercial launch is envisioned for 2027.

Keywords: drone,cargo drone,uav,logistics,surveillance,low carbon emissions,environment friendly