Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Protocells in the Archaean Rock Record: Implications for the Origin of Life and Detection of Biosignatures (ProtoSigns)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Ireland
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1499653.0
EU funding (EUR): 1499653.0
Participants: 1
Project status: SIGNED

Fossilised remains of protocells transitioning towards the first living organisms may be observable in the early rock record distorting our interpretation of biosignatures. Protocells – cellular structures existing prior to the emergence of life – would have comprised simple membranes and molecular machinery. The formation of complex protocells is poorly understood. The interpretation of fossilised microorganisms in the early rock record is steeped in controversy. The potential for abiotic microstructures to further complicate this interpretation has long been recognised but has not been systematically tested. Evidence suggests that prebiotic structures are very difficult to distinguish from microfossils. However, little is known about the chemical and physical characteristics of these ‘biomorphs’ that may enable us to tell the difference. This project will use a novel microfluidic approach to expand the experimental scope for formation of protocells of increasing complexity. Resulting microstructures will undergo silicification and diagenesis, the principal preservation pathway for early Archean microfossils. State-of-the-art analytical techniques will be used to characterise biomorphs, providing the first rigorous investigation of the feasibility of protocell preservation and how this might express in the geological record. These data combined with a predictive model and biological controls will allow for identification of key observables that will act as biogenicity indicators. Purported microfossils will then be examined and reinterpreted using the novel biosignatures. This project has the capacity to represent a paradigm shift in our fundamental understanding of the origin and evolution of life on Earth and possibly elsewhere in the Solar System. Collectively this will represent a major advance in our understanding of the geological record, providing the first comprehensive methodology to distinguish between abiotic, prebiotic, and biological microstructures.

Keywords: origin of life geobiology protocells
Breton Palaeography (BretPal)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland,France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 211024.4
EU funding (EUR): 211024.4
Participants: 2
Project status: SIGNED

BretPal seeks to answer the main question of what is Breton Caroline minuscule, who wrote it, and where? Despite advances in our understanding of early medieval Brittany's political history, our knowledge of Brittany's literary and intellectual history remains stunted due to a lack of being able to definitively ascribe manuscripts (and, therefore, the texts contained within) to Brittany. BretPal will establish parameters to identify those manuscripts from early medieval Brittany (c. 780–1100) based upon palaeographic and Digital Humanities methods. The project offers the first comprehensive narrative of the scribal and literary culture of early medieval Brittany, as well as an open-access digital database using the Archetype software. Further, the project will examine the wider impact that Breton intellectual culture had upon wider early medieval western Europe through the Breton diaspora from the ninth century onwards. BretPal will be hosted by the National University of Ireland, Galway (NUIG) and will be carried out under the auspices of the Moore Institute with a secondment at the École Pratique de Hautes Études, Université Paris, Sciences & Lettres.
Flying ATM for Environment Climate (F4EClim)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Germany,Netherlands,Spain
Call: ATM Excellent science and outreach for the aviation Green Deal (HORIZON-SESAR-2023-DES-ER-02, 2023)
Start date: 2024-09-01
End date: 2027-02-28
Duration (months): 30.0
Total project cost (EUR): 999938.75
EU funding (EUR): 999938.75
Participants: 3
Project status: SIGNED

Flying alternative trajectories for the benefit of Climate F4ECLIM's primary aim is to advance aCCFs by integrating weather forecasts and climate science to address uncertainties tied to CO2, contrails, ozone, methane, and water vapor climate effects. This involves evolving aCCFs to version 2.0, broadening their geographical scope (currently limited to the North Atlantic), considering diverse weather and seasonal patterns, and incorporating various climate metrics. These advancements will feed into a climate service for the aviation community. Additionally, F4ECLIM will explore aviation's potential to reduce its climate impact through the development of robust flight planning algorithms. These algorithms will identify eco-efficient aircraft trajectories, assessing the associated climate impact reduction and costs. Backtesting procedures will be employed to scrutinize trajectories and climate models, providing insights into model specifications. The project will culminate in recommendations and the introduction of key performance indicators (KPIs) to guide stakeholders in implementing eco-efficient trajectories, reducing uncertainties, and advancing understanding of the non-CO2 impact of aviation for a greener future.

Keywords: climate optimized,mitigating non co2 effects,met service,climate effects
Cell behaviour-aware power capability prediction and operation optimization of large-scale battery systems (ProBat)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-10
End date: 2027-06-09
Duration (months): 24.0
Total project cost (EUR): 252180.0
EU funding (EUR): 252180.0
Participants: 1
Project status: SIGNED

Large-scale battery system applications, e.g., transportation electrification and grid-level renewable energy integration, are vital for the EU to achieve net-zero emissions by 2050. In such battery systems, real-time operating behaviours of individual battery cells determine the system’s overall performance and safety, highlighting the need to develop cell behaviour-aware control algorithms for advanced battery system management. Thus, in this proposal, we will take into account the specific operating limits of all internal battery cells for accurately predicting and significantly boosting battery system's maximum allowable charge and discharge power, i.e., state of power (SoP). Then, the obtained cell behaviour-aware battery system SoPs will act as the operating power limits for further optimising the system's operation performance. As an MSCA-PF fellow, Dr. Weiji Han will receive crucial training at the Chalmers University of Technology and engage in detailed battery system modelling and control works which span the areas of circuit analysis, automatic control, and optimisation. The interplay between these areas will spark an innovative and productive throughput, including 1) an accurate prediction algorithm for the long-horizon SoPs of battery systems, 2) a high-efficiency dynamic reconfiguration algorithm for boosting battery system SoPs, and 3) an optimal control framework of dynamic reconfiguration for optimising battery system performance based on adapted deep reinforcement learning (DRL). The major novelties or contributions will include: considering both battery parameter update and operating constraints during the prediction horizon to enhance the prediction accuracy of long-horizon SoPs; unifying the modelling of reconfigurable battery systems to significantly reduce the modelling efforts and facilitate the formulation of control or optimisation problems; narrowing the search space and adapting the DRL method to achieve higher computational efficiency.

Keywords: battery management systems,power capability,state of power,battery reconfiguration,deep reinforcement learning
Learning from animals how to regenerate: multidisciplinary training programme in regenerative biology (REGENERATE-IT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,France,Sweden,Germany,Italy,Denmark,Switzerland,United Kingdom,Australia,Spain,Belgium,Austria
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 2974664.57
EU funding (EUR): 2747620.8
Participants: 29
Project status: SIGNED

The REGENERATE-IT Network brings together a full spectrum of disciplines – from fundamental to applied research – to train the next generation of researchers in regenerative biology and adjacent fields. While the natural regenerative ability of humans is limited, some animals have remarkable regenerative capacity. For example, planarian flatworms can restore all body parts from small pieces of tissue, salamanders can grow back lost limbs and repair damaged eyes, and zebrafish can regenerate their heart and fins. By identifying the common biological principles underlying the regenerative processes in these different animal models, we can learn a great deal on how to improve regenerative interventions in humans. Currently, regenerative animal models are studied in isolation, preventing the discovery of such shared mechanisms, and the REGENERATE-IT Network fills this gap. ESRs trained by REGENERATE-IT will obtain a broad and unique understanding of the fundamentals of regenerative biology and of the needs of research in regenerative medicine. The REGENERATE-IT Network therefore includes scientists working on regenerative model organisms such as flatworms, cnidarians, crustaceans, amphibians and zebrafish; stem cell scientists working on mouse and human models; scientists with impressive track records in translational research and experience with clinical trials; and experts in key technologies such as genomics, single cell sequencing, imaging and drug screening. REGENERATE-IT will train 10 ESRs and 1 associated doctoral researcher through research, secondments to other laboratories, consortium meetings, and workshops covering a wide range of topics. In addition to consolidating European strengths in regenerative biology, and training a cohort of next-generation scientists capable of cross-disciplinary research, REGENERATE-IT will combine and deliver theoretical and technological breakthroughs, and advance the frontiers of regenerative biology and medicine.

Keywords: regenerative biology,tissue and organ regeneration,animal models,stem cells,single cell sequencing,live imaging
Development of an Advanced Airway-On-A-Chip Model to Investigate Neuronal Hypersensitivity in Chronic Cough (REVEAL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1498775.0
EU funding (EUR): 1498775.0
Participants: 1
Project status: SIGNED

Coughing is one of the most frequent reasons for physician appointments, and chronic coughing affects one in every 10 people in Europe. It has severe consequences on the patients’ quality of life. Treatment options are limited. Because animal models do not accurately replicate the human disease, the underlying mechanisms that trigger the onset of chronic coughing remain unclear and several promising drug candidates have failed in clinical testing. Human in vitro models could overcome these hurdles if all relevant cell types are integrated. In the REVEAL project, we will develop a comprehensive airway in vitro model to gain insight into the mechanisms underlying the onset and manifestation of neuronal hypersensitivity in chronic cough. We will develop a novel airway-on-a-chip that replicates the complex architecture of human airway tissue with innervation, immunocompetence, differentiated epithelium, and perfusable vascularization using primary cells and iPSC-derived neurons. The novel chip will facilitate high-throughput experiments. Disease models will be created using cells from chronic cough patients followed by the induction of inflammation. We will investigate neuroimmune interactions that trigger neuronal hypersensitivity and use the chip for drug screening. The REVEAL model will help to reduce the burden of chronic cough by offering a better understanding of neuronal hypersensitivity in the airways. It will facilitate the development and testing of new drugs, offer a tool for personalized medicine, and provide a new approach methodology for risk assessment and toxicity testing. This will support the 3R principles, replacing and reducing animal testing in basic and applied research. The anticipated outcome of this project will also have an impact on other highly prevalent chronic airway diseases by providing a platform technology to study conditions such as asthma and chronic obstructive pulmonary disease (COPD), achieving a positive impact for many patients.

Keywords: in vitro modelling,tissue engineering,microfluidic systems,3d tissues,organ on a chip
Late-stage clinical development of Chikungunya vaccines in endemic countries (CHIKV) and Controlled Human Infection Models for SARS-CoV2 and other beta coronaviruses (CHIM). (CHIKVAX_CHIM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Other health destinations
Action type: COFUND actions
Countries involved: Norway
Call: CEPI 4 - Contribution to the Coalition for Epidemics Preparedness Initiative (HORIZON-HLTH-2022-CEPI-15-IBA, 2022)
Start date: 2023-06-01
End date: 2028-11-30
Duration (months): 66.0
Total project cost (EUR): 100000000.0
EU funding (EUR): 70000000.0
Participants: 1
Project status: SIGNED

A Framework Partnership Agreement (FPA) between the Coalition for Epidemic Preparedness Innovations (CEPI) and the European Union (EU) was signed in April 2019, to finance and coordinate the development of new medical countermeasures to prevent and contain infectious disease epidemics, which are of particular concern to low- and middle-income countries. As part of the FPA, a call for proposals (CfP) was launched jointly with the EU and supported the preclinical development of Rift Valley Fever Virus vaccines and the late-stage development of Chikungunya virus vaccines (CHIKV). While previous funding has led to the development of pre-licensure CHIK vaccines, in this current application we like to further advance our CHIK vaccine programme, and support CHIK vaccines that are near or have achieved regulatory licensure by supporting their clinical development into phase IV clinical trials to increase our understanding of the long-term safety, durability of protection, and effectiveness against virologically confirmed disease. Furthermore, we would like to expand the use indication by supporting clinical trials in vulnerable populations, including children, immunosuppressed and pregnant women. As part of this grant application, we also like to launch a CfP on Controlled Human Infection Models (CHIM). The overall objective of the CHIM proposal is to support research projects that increase knowledge in vaccine-induced mucosal immunity and advance the development of transmission-blocking vaccines against coronaviruses and other potential respiratory viral threats. The expected outcome of this CfP is to create a global network of experts conducting CHIM at a high level of consistency and reliability. This current grant application seeks to leverage €70M from Horizon Europe, which will be supplemented with €30M from CEPI making a pool of €100M. Awards will have a 36–48-month duration and will be administered by the CEPI secretariat.

Keywords: chikungunya,controlled human infection models,chim,lmics,clinical development,vaccines
Visual Robot Programming (VRP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Transition Open 2021 (HORIZON-EIC-2021-TRANSITIONOPEN-01, 2021)
Start date: 2022-06-01
End date: 2024-12-31
Duration (months): 31.0
Total project cost (EUR): 1141648.75
EU funding (EUR): 1141648.0
Participants: 1
Project status: CLOSED

This project aims to commercialize the novel technology called Visual Robot Programming (VRP): a no-code gesture-control robot programming solution. The goal is to exploit the results of the FET-Open project GOAL-Robots and raise the Technology Readiness Level (TRL) from TRL 4 to TRL 6 and register a spin-off within 24 months. Current industrial robots are designed to repeat the same task millions of times to enable high-volume manufacturing of a single product, but are not deployable for high-mix low-volume manufacturing as required by SMEs. To empower SMEs to adopt automation, VRP enables real-time gesture-based robot programming: the user demonstrates the desired motion using hand gestures, and the industrial robot tracks and imitates the identical motion in real-time. Using this intuitive technology, any user is empowered to teach industrial robots without prior knowledge in robotics and with minimal training. VRP unlocks new automation potential in the SME segment and allows the workforce to shift to higher-skilled and more rewarding tasks. The four objectives of this project are: (1) technology development and maturation of the GOAL-Robots research results to develop AI-assisted VRP (2) industrial pilot projects to demonstrate the solution in industry (3) business validation to demonstrate commercial viability and (4) spin-off and investor readiness.

Keywords: industry 4 0,digitalization of manufacturing processes,industrial automation
Climate resilient and environmentally sustainable transport infrastructure, with a focus on inland waterways (CRISTAL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Innovation actions
Countries involved: Poland,Belgium,Italy,Germany,France,Hungary,Greece,Czechia,United Kingdom
Call: Climate resilient and environmentally sustainable transport infrastructure, with a focus on inland waterways (HORIZON-CL5-2021-D6-01, 2021)
Start date: 2022-09-01
End date: 2025-12-31
Duration (months): 40.0
Total project cost (EUR): 6837452.5
EU funding (EUR): 6371048.5
Participants: 16
Project status: SIGNED

It is the key objective of the project CRISTAL (40 months) to increase the share of freight transport on inland water transport (IWT) by a minimum of 20% and to demonstrate on its three pilot sites (Italy, Poland and France) strategies to improve reliability by 80%. CRISTAL project will assure IWT capacity at 50% even during extreme weather events. Towards that CRISTAL will co-create, test and implement integrated, cooperative and innovative solutions in its three pilot partners’ areas identified in Italy, France and Poland. The project will include the aspects of technological innovation/development and digitalization; further advancement towards the Physical Internet, governance solution and business models, will be proposed while targeting sustainability and infrastructure resilience requirements.

Keywords: intelligant transport system,sustainable transport,digitalisation,synchromodality,modal shift,resilience
A calorimeter at atomic resolution (CLAR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 2955000.0
EU funding (EUR): 2955000.0
Participants: 1
Project status: SIGNED

Molecular interactions are at the basis of all biological processes and often include specific interactions between macromolecules (protein, RNA, DNA) and small-molecule ligands, such as cofactors, hormones, drugs, or metabolites. Detailed and quantitative knowledge of these interactions is critical for a molecular understanding of these biological processes and developing new therapeutic solutions. A complete comprehension of molecular recognition requires a full characterization of the geometry and dynamics of the molecular complex. This includes not only the internal dynamics of each partner but also the dynamics at the interface, which to date remain mostly unexplored experimentally. The physical chemistry frame for studying intra- and inter-molecular interactions is thermodynamics. The extent to which two molecules interact is dictated by the Gibbs energy change (ΔG) of the interactions, which is composed of enthalpic (ΔH) and entropic (ΔS) terms. X-ray crystallographic and NMR structures provide a detailed description of the static interactions associated with enthalpic contributions. However, up to now, the entropic components remain difficult to address experimentally. The overarching goal of this proposal is to develop a calorimeter at atomic resolution. To achieve that goal, a new NMR spectroscopy approach, relying mainly on the nuclear Overhauser effect, will be developed. It is anticipated that quantitative thermodynamic measurements within molecules and molecular complexes will open a new avenue in the fundamental understanding of how atomistic mechanism(s) create a function. Beyond the fundamental findings, we foresee applications in translational medicine, drug design, and computer-assisted molecular design.

Keywords: bionmr spectroscopy,thermodynamics of protein and protein ligand complexes,entropy