Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The African Neolithic: A genetic perspective (AfricanNeo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-11-01
End date: 2022-10-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

The spread of farming practices in various parts of the world had a marked influence on how humans live today and how we are distributed around the globe. Around 10,000 years ago, warmer conditions lead to population increases, coinciding with the invention of farming in several places around the world. Archaeological evidence attest to the spread of these practices to neighboring regions. In many cases this lead to whole continents being converted from hunter-gatherer to farming societies. It is however difficult to see from archaeological records if only the farming culture spread to other places or whether the farming people themselves migrated. Investigating patterns of genetic variation for farming populations and for remaining hunter-gatherer groups can help to resolve questions on population movements co-occurring with the spread of farming practices. It can further shed light on the routes of migration and dates when migrants arrived. The spread of farming to Europe has been thoroughly investigated in the fields of archaeology, linguistics and genetics, while on other continents these events have been less investigated. In Africa, mainly linguistic and archaeological studies have attempted to elucidate the spread of farming and herding practices. I propose to investigate the movement of farmer and pastoral groups in Africa, by typing densely spaced genome-wide variant positions in a large number of African populations. The data will be used to infer how farming and pastoralism was introduced to various regions, where the incoming people originated from and when these (potential) population movements occurred. Through this study, the Holocene history of Africa will be revealed and placed into a global context of migration, mobility and cultural transitions. Additionally the study will give due credence to one of the largest Neolithic expansion events, the Bantu-expansion, which caused a pronounced change in the demographic landscape of the African continent

Keywords: holocene human history,neolithic,africa,development of farming,human migration,human population genetics,human demographic history
Innovative therapeutic tools to ameliorate chemotherapy-induced cardiotoxicity (p38_InTh)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-12-01
End date: 2020-08-31
Duration (months): 21.0
Total project cost (EUR): 149937.5
EU funding (EUR): 149937.0
Participants: 1
Project status: CLOSED

p38_InTh aims at improving the potency of a new class of highly specific p38 pathway inhibitors and validate their potential therapeutic use to ameliorate chemotherapy-induced cardiotoxicity without affecting the cancer cell toxicity of the chemotherapeutic. Chemotherapeutics used for cancer treatments have serious side effects, both the most broad-spectrum ones (such as anthracyclines) and the directed ones (such as trastuzumab). In particular, the cardiotoxicity is a major issue associated to chemotherapy. Cardiooncology research has recently emerged to tackle this serious unmet medical need. The cardiotoxicity induced by chemotherapeutics includes from arrhythmia to heart failure. To mitigate it, cardiooncologists usually adjust the treatment with reduced doses for a longer period, but this makes the anticancer treatments less efficient and consequently reduces the quality of life of the patients. There is evidence that cardiomyocyte death induced by anthracyclines involves activation of a specific p38 pathway, suggesting that inhibition of this pathway may reduce the cardiotoxicity associated with chemotherapeutics. Over the last two decades, many p38 pathway inhibitors have been developed by industry. However, these are mostly ATP competitors and have shown disappointing results in clinical trials. In contrast, we have recently identified novel compounds that inhibit only one of the target isoforms and through a novel MoA, selectively antagonizing the activation of this isoform by one of its protein partners. We propose to improve the potency of these hits and validate their potential therapeutic use to ameliorate chemotherapy-induced cardiotoxicity without affecting the cancer cell toxicity. Importantly, our new drug would inhibit only a subset of the p38 pathway regulated functions, which is expected to result in increased specificity, thereby overcoming the undesired side-effects found in clinical trials for the classical ATP competitive p38 pathway inhibitors.

Keywords: chemotherapy,cardiotoxicity,anthracycline,cardiomyocyte,cell death
ARCTIC CULTURES: SITES OF COLLECTION IN THE FORMATION OF THE EUROPEAN AND AMERICAN NORTHLANDS (ARCTIC CULT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-10-01
End date: 2024-09-30
Duration (months): 84.0
Total project cost (EUR): 1996250.0
EU funding (EUR): 1996250.0
Participants: 1
Project status: SIGNED

The Arctic has risen to global attention in recent years, as it has been reconfigured through debates about global environmental change, resource extraction and disputes over sovereign rights. Within these discourses, little attention has been paid to the cultures of the Arctic. Indeed, it often seems as if the Circumpolar Arctic in global public understanding remains framed as a 'natural region' - that is, a place where the environment dominates the creation of culture. This framing has consequences for the region, because through this the Arctic becomes constructed as a space where people are absent. This proposal aims to discover how and why this might be so. The proposal argues that this construction of the Arctic emerged from the exploration of the region by Europeans and North Americans and their contacts with indigenous people from the middle of the eighteenth century. Particular texts, cartographic representations and objects were collected and returned to sites like London, Copenhagen, Berlin and Philadelphia. The construction of the Arctic thereby became entwined within the growth of colonial museum cultures and, indeed, western modernity. This project aims to delineate the networks and collecting cultures involved in this creation of Arctic Cultures. It will bring repositories in colonial metropoles into dialogue with sites of collection in the Arctic by tracing the contexts of discovery and memorialisation. In doing so, it aspires to a new understanding of the consequences of certain forms of colonial representation for debates about the Circumpolar Arctic today. The project involves research by the Principal Investigator and four Post Doctoral Researchers at museums, archives, libraries and repositories across Europe and North America, as well as in Greenland and the Canadian Arctic. A Project Assistant based in Oxford will help facilitate the completion of the research.

Keywords: cultural geography,historical geography,arctic anthropology,history of arctic exploration
Intelligent Vessels using space technology for Safety on board. (i-vSAVE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Spain
Call: Engaging SMEs in space research and development (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

i-vSave is a disruptive maritime communication system with integrated satellite communication and positioning, GSM /3G connectivity, on-board LoRa sensor network and a terrestrial server for data processing and management, that promotes overall communications, safety and crew/passenger comfort on merchant, passenger and recreational vessels. Maritime companies, crew and passenger (target users) have a need for real-time information exchange, safety and 24/7 connectivity. I-vSave collects and processes data from satellites, databases and sensors to enhance decision-making by captain, provide fleet management tools and alert in the case of safety threats, while the on-board sensor network monitors the ships’ operation and guard passenger and crew safety (LoRa man overboard). Furthermore, crew and passengers benefit by 24/7 communication services (GSM/Wi-Fi) at global coverage of up to 99%. The innovation lies in the integrated solution solving the needs of maritime companies, crew, passengers and other maritime stakeholder. A hardware prototype has been developed and the system has been tested in the port of Algecira, such that the project is at TRL6. However, satellite data & communications and software and firmware development form a key pillar in this project, for which we require a feasibility study. Upon commercialization of i-vSave in 2020, we will sell our product in Europe, Asia and USA where more than 90% of the shipbuilding, maintenance, repair and conversion (SMRC) market is located. For Phase II a budget of € 1.2M is estimated. As a result of i-vSave, product revenues will reach € 6.2M in the 5th year with a ROI of 3.9. The company will have grown by 6 employees. Europe has the largest global market for passenger and cruise vessels and our solution will specifically target this sector, thereby strengthening the position of the EU within the maritime communications sector and exploiting the resources of the European Galileo and Copernicus satellite

Keywords: maritime safety,real time,communication,monitoring,space,cloud
An augmented intelligence-enabled stimulating framework for deep energy renovation delivering occupant-centered innovations (RINNO)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Innovation actions
Countries involved: Ireland,Spain,Austria,Spain,Italy,Poland,Finland,Greece,Greece,Greece,Poland,France,France,Denmark,Denmark,United Kingdom,Denmark
Call: Decarbonisation of the EU building stock: innovative approaches and affordable solutions changing the market for buildings renovation (H2020-LC-SC3-EE-2019, 2019)
Start date: 2020-06-01
End date: 2024-05-31
Duration (months): 48.0
Total project cost (EUR): 4748672.34
EU funding (EUR): 3998534.75
Participants: 20
Project status: SIGNED

RINNO envisions to deliver a framework solution that will help drastically accelerating the rate of deep renovation in EU building stock reaching an ambitious annual renovation rate of 3.5%. Its ultimate goal is to develop, validate and demonstrate an operational interface with augmented intelligence and an occupant-centered approach that will streamline and facilitate the whole lifecycle of building renovation (planning-design, retrofitting, monitoring). This concept has at its foundation, a set of cost-attractive, environmentally friendly, multi-functional and easily applicable building-related innovations, grouped into: a) plug-n-play, modular building envelope solutions and b) RES, hybrid and storage solutions. RINNO couples the above with innovative retrofitting processes, methods and tools, characterized by low tenants’ disruption. These comprise: efficient (off/on-site) construction strategies, on-the-job AR facilitating environment and multi-stakeholder collaboration, which are expected to shrink the time and cost required for deep renovation, while improving buildings’ performance; all with a short payback period of <4 years on average. The above will be supported businesswise with novel business models aligned with the circular economy principles, enriched with investment de-risking tools and advanced crowd-equity/crowd-lending schemes. RINNO is expected to impact the EU inefficient building stock by a) reaching an ambitious annual renovation rate of 3.5%; b) primary energy savings of 165 GWh/year; c) a reduction of electricity cost by at least 30%; d) a total cost / time reduction in comparison with typical renovation by more than 30% and 40% respectively, and e) an estimated reduction of 40,400 tons CO2-eq/year. RINNO optimized renovation roadmap will be demonstrated at 4 large scale (3,386m2) pilot use cases after being pre-piloted, covering different EU climatic zones and markets of diverse maturity in the renovation sector.

Keywords: deep energy renovation,augmented intelligence,less energy intensive,multi functional building,elements,cost effective construction and installation methods,it solutions,business models
Homological mirror symmetry, Hodge theory, and symplectic topology (HMS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-08-31
Duration (months): 66.0
Total project cost (EUR): 1498686.0
EU funding (EUR): 1498686.0
Participants: 1
Project status: SIGNED

Mirror symmetry is a deep relationship between algebraic and symplectic geometry, with origins in string theory. It was originally envisioned as an isomorphism between the Hodge theory of an algebraic variety and the `quantum Hodge theory' of a `mirror' symplectic manifold, but it was subsequently realized by Kontsevich that the relationship went far deeper. His Homological Mirror Symmetry (HMS) conjecture predicts an equivalence between the derived category of the variety and the Fukaya category of its mirror, and has far-reaching implications for diverse areas of mathematics. In previous work I have proved the conjecture in fundamental cases, established its precise relationship with the Hodge-theoretic version of mirror symmetry, and used these results to solve questions in enumerative geometry and symplectic topology. The proposed research centres on HMS, new aspects of its relationship with Hodge theory, and new applications to symplectic topology. It is split into four projects: 1. Prove HMS for Gross-Siebert mirrors (this covers the vast majority of mirror pairs proposed in the literature). As a preliminary step in this direction we will prove HMS for Batyrev mirrors. 2. Prove that HMS implies mirror symmetry for open Gromov-Witten invariants. The key step will be the construction of a mirror to the Abel-Jacobi map. 3. Enrich the Hodge-theoretic structures emerging from HMS with rational structures. The key step will be to show that the Gamma rational structure on quantum Hodge theory emerges from the topological K-theory of the Fukaya category. 4. The Lagrangian cobordism group is an important invariant of a symplectic manifold, which can be used to study some of the most fundamental questions in symplectic topology such as the classification of Lagrangian submanifolds. We will elucidate its structure by using its relationship, via HMS, with the Chow group of the mirror variety.

Keywords: homological mirror symmetry,symplectic topology,hodge theory,chow group
Amplifying Human Perception Through Interactive Digital Technologies (AMPLIFY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-07-01
End date: 2022-09-30
Duration (months): 75.0
Total project cost (EUR): 1925250.0
EU funding (EUR): 1267750.0
Participants: 2
Project status: CLOSED

Current technical sensor systems offer capabilities that are superior to human perception. Cameras can capture a spectrum that is wider than visible light, high-speed cameras can show movements that are invisible to the human eye, and directional microphones can pick up sounds at long distances. The vision of this project is to lay a foundation for the creation of digital technologies that provide novel sensory experiences and new perceptual capabilities for humans that are natural and intuitive to use. In a first step, the project will assess the feasibility of creating artificial human senses that provide new perceptual channels to the human mind, without increasing the experienced cognitive load. A particular focus is on creating intuitive and natural control mechanisms for amplified senses using eye gaze, muscle activity, and brain signals. Through the creation of a prototype that provides mildly unpleasant stimulations in response to perceived information, the feasibility of implementing an artificial reflex will be experimentally explored. The project will quantify the effectiveness of new senses and artificial perceptual aids compared to the baseline of unaugmented perception. The overall objective is to systematically research, explore, and model new means for increasing the human intake of information in order to lay the foundation for new and improved human senses enabled through digital technologies and to enable artificial reflexes. The ground-breaking contributions of this project are (1) to demonstrate the feasibility of reliably implementing amplified senses and new perceptual capabilities, (2) to prove the possibility of creating an artificial reflex, (3) to provide an example implementation of amplified cognition that is empirically validated, and (4) to develop models, concepts, components, and platforms that will enable and ease the creation of interactive systems that measurably increase human perceptual capabilities.

Keywords: user experience,augmented senses,user interface technologies
Advanced III-V Materials and Processes Enabling Ultrahigh-efficiency ( 50%) Photovoltaics (AMETIST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Finland
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 2492719.0
EU funding (EUR): 2492719.0
Participants: 2
Project status: SIGNED

Compound semiconductor solar cells are providing the highest photovoltaic conversion efficiency, yet their performance lacks far behind the theoretical potential. This is a position we will challenge by engineering advanced III-V optoelectronics materials and heterostructures for better utilization of the solar spectrum, enabling efficiencies approaching practical limits. The work is strongly motivated by the global need for renewable energy sources. To this end, AMETIST framework is based on three vectors of excellence in: i) material science and epitaxial processes, ii) advanced solar cells exploiting nanophotonics concepts, and iii) new device fabrication technologies. Novel heterostructures (e.g. GaInNAsSb, GaNAsBi), providing absorption in a broad spectral range from 0.7 eV to 1.4 eV, will be synthesized and monolithically integrated in tandem cells with up to 8-junctions. Nanophotonic methods for light-trapping, spectral and spatial control of solar radiation will be developed to further enhance the absorption. To ensure a high long-term impact, the project will validate the use of state-of-the-art molecular-beam-epitaxy processes for fabrication of economically viable ultra-high efficiency solar cells. The ultimate efficiency target is to reach a level of 55%. This would enable to generate renewable/ecological/sustainable energy at a levelized production cost below ~7 ¢/kWh, comparable or cheaper than fossil fuels. The work will also bring a new breath of developments for more efficient space photovoltaic systems. AMETIST will leverage the leading position of the applicant in topical technology areas relevant for the project (i.e. epitaxy of III-N/Bi-V alloys and key achievements concerning GaInNAsSb-based tandem solar cells). Thus it renders a unique opportunity to capitalize on the group expertize and position Europe at the forefront in the global competition for demonstrating more efficient and economically viable photovoltaic technologies.

Keywords: photovoltaics,high efficiency solar cells,iii v solar cells,dilute nitride solar cells,multi junction solar cells,molecular beam epitaxy,satellite solar cells