Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Targeted Nano-Photomedicines for Multi-spectral Photodynamic Therapy of Cancer (NANO-PHOTOMED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships (Return Phase)
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: India
Call:  (FP7-PEOPLE-2007-4-2-IIF, 2007)
Start date: 2009-10-01
End date: 2010-09-30
Duration (months): 12.0
Total project cost (EUR): 15000.0
EU funding (EUR): 15000.0
Participants: 1
Project status: CLOSED

We propose to develop multifunctional, targeted nano-photomedicines that are capable of bypassing biological barriers to deliver nano-engineered photosensitizer drugs and molecular-imaging agents to tumor tissues and angiogenetic micro-vasculature. Specifically, a unique nanomedicine system for targeted multi-spectral photodynamic therapy is proposed. The system consists of (i) luminescent quantumdot (QD) conjugated with photosensitizer (PS) drugs, which can be sensitized at its maximum efficiency using radiations of deep-tissue penetration (ii) molecular-imaging agents for the early stage detection and in situ treatment-effect analysis (iii) active targeting ligands to specifically target tumor and micro-vasculature. During the incoming phase, QDs of ZnS, Y2O3 and Gd2O3 emitting multi-spectral light under excitation with deep high-tissue penetrating radiations will be conjugated with PS so as to sensitize them at their characteristic absorption using Fluorescent Resonant Energy Transfer (FRET). The QD-PS will be combined with MRI contrast agents using `core/shell’ nanotechnology and made water soluble by capping with polyethylene glycol (PEG). Finally, the nanomedicine will be connected with tumor specific ligands such as folic acid, MAbs and peptides. Optimization of nanomedicine will be carried out by studying dark and photo-toxicity in normal and cancer cell-lines in vitro. Photodynamic treatment will be carried out in pre-clinical animal models using multispectral radiations under different photo- and drug-dose conditions, followed by molecular imaging (MRI) based estimation of PDT response-dose inter-relationships. During the return phase, scanning probe imaging based investigations on the mechanism-of-activity of nano-photomedicines at intra-cellular regions leading to cell-death (apoptosis) will be investigated.
RESILIENCE AND STABILITY IN DEVELOPING TOOLS FOR SUSTAINABLE FOREST MANAGEMENT AND RESTORATION (RESTORE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships (Return Phase)
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Russian Federation
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2012-03-01
End date: 2013-02-28
Duration (months): 12.0
Total project cost (EUR): 15000.0
EU funding (EUR): 15000.0
Participants: 1
Project status: CLOSED

The overall objective of RESTORE is to synthesize the knowledge of the biodiversity of pristine European boreal forests, available only in Russia, and bring it in use in European context. That will be done by combing the Russian knowledge and data from pristine boreal forests to that from managed boreal forests in Finland in order to estimate boreal forest ecosystem resilience and stability and develop tools for sustainable forest management (SFM) and restoration. The results are of crucial importance for EU and national policy makers, state forest managers, forest owners, conservationists and NGOs in both Europe and Russia. RESTORE covers 3 types of activities: research, development and dissemination. RESTORE first time estimates stability and resilience using biodiversity indicators for species groups, structures and processes of key importance for biodiversity. Natural disturbances (fires and windthrows) and felling treatments are considered as perturbations. Originality and innovative nature of the project is in its unique dataset, a gradient from pristine to intensively managed forests, and system approach in practical implementation of basic research. The management and conservation tools will be developed according to resilience, return interval after disturbance and stability threshold of each ecosystem type depending on socio-economic context, management history, site conditions and natural disturbance regimes. The data collected and analyzed in RESTORE will be published at the European Forest Data Centre of the European Commission, managed by JRC in cooperation with Metla&amp;apos;s web team to define future guidelines for SFM. RESTORE is also in accordance with FAO&amp;apos;s concept of SFM. In future RESTORE will be a part of a planned broad scale EU network for identifying the thresholds in ecosystem resilience and stability in a gradient of land-use intensity.
A new type adsorption-resorption cycle for the combined power generation and refrigeration driven by low grade heat (ADSOR-RESOR CYCLE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships (Return Phase)
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: China
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2012-01-01
End date: 2012-12-31
Duration (months): 12.0
Total project cost (EUR): 15000.0
EU funding (EUR): 15000.0
Participants: 1
Project status: CLOSED

A new type of combined cycle of power generation and refrigeration, which is driven by the low grade heat such as the waste heat from chemical engineering factory and combustion turbine, and the low grade heat from solar energy, is proposed in the proposal. This new type cycle mainly includes two high temperature adsorbers with high temperature salt as adsorbent, and two low temperature adsorbers with low temperature salt as adsorbent. The working processes mainly include desorption and resorption processes. The desorption process of high temperature adsorber generates electricity, and the resorption process between two types of adsorbers, i.e. low temperature and high temperature adsorbers, generates refrigeration effect. In order to improve the power generation and refrigeration efficiency, a superheater and a precooler are designed in the cycle. Compared with traditional Rankin cycle that utilizes water as working media for power generation, this new type of combined cycle utilizes ammoniate salt as working media, thus it has higher efficiency because the temperature for desorption process of the ammoniate salt varies in the process of heating, and the average heating temperature of new type cycle is higher than that of water media in the Rankin cycle, which has an isothermal heating phase while the water vaporizes. If compared with combined absorption cycle for power generation and refrigeration, which is based on the Kalina cycle, this new type cycle not only has simple structure, but also has higher refrigeration efficiency for the reason of resorption refrigeration process, and it also has higher reliability because there are very less liquid ammonia exists in the system.
Development of the circuits in the locust brain for the early detection and avoidance of looming objects. (NEURAL DEVELOPMENT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships (Return Phase)
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Argentina
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2011-09-01
End date: 2012-11-29
Duration (months): 12.0
Total project cost (EUR): 15000.0
EU funding (EUR): 15000.0
Participants: 1
Project status: CLOSED

Looming detection is crucial for animals to efficiently respond to approaching stimuli. Extensive research has been done to characterise and understand the neural circuits underlying such capacity. The locust has been established as a preferred model because it has a pair of large and uniquely identified visual neurons, the lobula giant movement detector (LGMD) and the postsynaptic descending contralateral movement detector (DCMD) that respond selectively to the images of an object approaching towards its eye. These neurons have been associated with the triggering of last moment avoidance responses such as gliding dives during flight. So far, all studies have used adult locusts. However these animals avoid predation by birds throughout their lives and the preferred escape response varies during development. Juvenile locusts display escape behaviours on the ground, such as hiding and jumping, that require more time than emergency dives and therefore are triggered early in the loom. DCMD may have a role in guiding these early reactions as it starts responding long before collision. However there have been no attempts yet to record from the DCMD during hiding. The present research aims at characterising the visual cues that produce the hiding response in the adult and studying the possible involvement of the LGMD and DCMD neurons in such behaviour. It also intends to quantify the behavioural strategies displayed at different stages of the locust’s life, relating them to the development of the neural circuit involved in looming detection. For this study we will use electrophysiological recordings in juvenile and adult locusts. We will also study the ultrastructure and synaptic connections during development, and relate it to what is already known in the adult. This may lead to a better understanding of the LGMD-DCMD circuitry and an improvement of the biologically inspired robots and warning sensor for imminent collisions in cars that are already based in such circuit.
Quantum aspects of extended supersymmetric gauge theories (QUANTUMSUPERSYMMETRY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships (Return Phase)
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Russian Federation
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2013-01-01
End date: 2013-12-31
Duration (months): 12.0
Total project cost (EUR): 15000.0
EU funding (EUR): 15000.0
Participants: 1
Project status: CLOSED

The project is aimed at the study of quantum aspects of extended supersymmetric field theories with various number of supersymmetries in three and four space-time dimensions. In particular we will develop extended superfield approaches to superconformal gauge theories with N=4 supersymmetry in four dimensional space-time and to supersymmetric Chern-Simons-matter theories with N=3,4,6,8 supersymmetries in three-dimensional space-time. Various classical and quantum aspects of these theories such as the construction of quantum effective action and computation of correlation functions of composite operators will be considered by using the developed extended superspace methods. These problems are motivated by the development of superstring / M-theory which is considered to be a candidate for the unified theory of all fundamental interactions of elementary particles. In particular, the four-dimensional N=4 supergauge theories effectively describe systems of D3 and M5 branes in supergravity and M-theory while three-dimensional N=6 and N=8 supergauge theories correspond to M-theory 2-branes. This gives rise to different manifestations of so-called AdS/CFT correspondence (or field theory / gravity correspondence). Within this project we will explore the properties of classical and quantum dynamics of above mentioned extended supersymmetric field theories that will shed new light on various aspects of the field theory / gravity correspondence.
Mathematical models for diffusion controlled systems: diffusion on cell membrane, cluster formation and maintenance (MODELLING DIFFUSION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships (Return Phase)
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Argentina
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2012-07-01
End date: 2013-06-30
Duration (months): 12.0
Total project cost (EUR): 15000.0
EU funding (EUR): 15000.0
Participants: 1
Project status: CLOSED

Assembly of transient and stable signaling platforms in the plasma membrane of cells has been implicated in functions as varied as death and survival, polarity, differentiation, migration, cell-cell communication, virus entry, exocytosis, endocytosis. Naturally, the assembly of signaling microdomains requires the use of most complex molecular mechanisms capable of transducing intrinsic or extrinsic information into the actual making of the domain. Consensus exist that the lateral diffusion and heterogeneity of membrane proteins is absolutely necessary. However, more and more data indicate that the clustering of specific proteins to form a signaling platform involves as well the free lateral diffusion of stable assemblies of sphingoipids and cholesterol (rafts). Despite their fundamental relevance for cell function, the basic events responsible for the formation and dynamics of membrane microdomains is not well understood. Mathematical models are very useful tools for describing diffusion processes in an inhomogeneous medium with some anomalies as well as self-organized systems. Hence, it is my plan to use mathematical models to study the formation of protein-lipid clusters and how normal diffusion on an inhomogeneous membrane can be modified. The formation of protein clusters is a necessary condition for cell polarity and it could be related with the generation of pattern. I will propose a Turing-mechanism model to know if it is possible to generate stable spatial inhomogeneity on the cell surface. In order to formulate the equations it will be needed to make some assumptions about the biological system. Made assumptions will be refused or accepted according to the comparative analysis between theoretical results and experimental data. My background in physics make me feel suitable for undertaking the task of modelling these features. The validation experiments will be performed in the laboratory of Prof. Carlos Dotti where I have chosen to carry out this project.
Deterministic Forecasting of Rogue Waves in the Ocean (DEROGUE WAVES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships (Return Phase)
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Russian Federation
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2012-08-01
End date: 2013-07-31
Duration (months): 12.0
Total project cost (EUR): 15000.0
EU funding (EUR): 15000.0
Participants: 1
Project status: CLOSED

Rogue or freak waves are short wave groups of anomalously high and steep waves (compared to ordinary sea waves) which have propensity to come seemingly out of nowhere. Such waves represent real danger even to the largest ships and offshore structures. Rogue waves cannot be prevented, but a better prediction could save lives. The present day forecasting of rogue waves is PROBABILISTIC, i.e. only the probability of freak wave occurrence in a given place and time is found as a result of wind wave modeling. The project is aimed at developing a radically new way of rogue wave forecasting – DETERMINISTIC FORECASTING. The main idea is as follows: although the sea waves are inherently random there exist situations where wave motion is constrained in a special way (e.g. wave on currents, above certain bottom topography), which decreases the number of “effective” spatial dimensions and makes deterministic forecasting possible. Such situations are characterized by particularly high risk of rogue waves. The objectives of the project are to fill the gaps in understanding of fundamental mechanisms of rogue waves and upon this basis to improve their prediction. The Fellow, one of the top scientists of his generation, is uniquely qualified to adapt the most advanced mathematical approaches developed for weakly nonlinear models to describe realistic rogue waves. The research will employ: (i) advanced analytical methods, both exact and asymptotic ones (making use of the expertise of the Host); (ii) a uniquely complete range of 2D and 3D numerical models from weakly to fully nonlinear (mostly developed by the Fellow); (iii) laboratory, in-situ and meteorological data will be used for validation of the models. The developed techniques will enable one to predict not only a high probability of a freak wave, but also WHEN, WHERE and WHAT KIND OF ROGUE WAVE to expect. This will dramatically reduce the risks involved for lives, ships, on-shore and offshore structures, and environment.
New modular self-assembled homogeneous catalysts for asymmetric synthesis in water (MODUCAT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships (Return Phase)
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Russian Federation
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2012-06-18
End date: 2013-06-17
Duration (months): 12.0
Total project cost (EUR): 15000.0
EU funding (EUR): 15000.0
Participants: 1
Project status: CLOSED

There is a continuous interest to apply homogeneous catalysis to asymmetric synthesis, which is the elective method for drugs production in pharmaceutical industry. Asymmetric catalysis provides the cheapest synthetic route to optically active compounds with minimal number of steps and reduced use of expensive chiral substrates. Replacing conventional methods with those involving asymmetric catalysis is then mandatory to reduce considerably energy/materials costs and the environmental impact of chemical manufacturing. The improvement of either efficiency and selectivity of traditional molecular chiral catalysts is a time consuming and expensive procedure that may be bypassed by the development of the innovative &amp;quot;modular catalysis&amp;quot; on which the MODUCAT proposal is concerning. The accomplishment of MODUCAT milestones will boost the application of asymmetric catalysts to several industrial processes. The main objectives of the project are: (1) to develop the modular assemblage of a chiral catalyst consisting of two independent units, separately responsible for activity and enantioselectivity. Such units, assembled together by Coulombic and/or hydrophobic forces, should form an innovative catalyst conjugating activity with enantioselectivity; (2) to validate the MODUCAT ideas in model catalytic asymmetric processes carried out in aqueous media. While the few known examples of &amp;quot;modular catalysts&amp;quot; find application in non-polar media, we propose to use Ag/Au NPs functionalized with SAMs of optically active charged molecules to bring about the modular approach in polar solvents. While the Fellow&amp;apos;s background in catalysis, organometallic/colloidal chemistry, particularly dealing with charged NPs, is a big asset that guarantees high chance to reach the goals of the project, his training in preparation of water soluble catalysts and their application to aqueous systems, where the Host has a recognized experience, is a fundamental prerequisite for the success of the project.
Investigation of mathematical models for thin-film flows (TFE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships (Return Phase)
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ukraine
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2012-10-08
End date: 2013-10-07
Duration (months): 12.0
Total project cost (EUR): 15000.0
EU funding (EUR): 15000.0
Participants: 1
Project status: CLOSED

This research project will bring together Dr Roman Taranets, an outstanding young researcher at the Ukrainian National Academy of Sciences, and Professor John King, a leading expert in the theory of thin film flows at Nottingham University, UK. The research will be focussed on flows of thin liquid and polymer films. The combination of Dr Taranets’ background in research methods for the rigorous investigation of the qualitative properties of solutions to nonlinear partial differential equations and the host’s expertise in formal asymptotic methods and contacts with a range of industry-driven applications will be an ideal basis for a successful fellowship. During the research project, we will • study exact asymptotic behaviour travelling wave solutions for the thin film equation with non-zero contact angles; • show the existence of a generalized solution for multi-dimensional coating flow models without surfactant and to investigate the behaviour of support of these solutions; • investigate the asymptotic behaviour of generalized solutions for multi-dimensional coating flows with surfactant; • put in place additional research programmes involving novel areas of application and employing innovative combinations of mathematical techniques. Benefits of this transfer of knowledge will include the implementation of the collaborative research programmes above, the initial training of both early-career researchers in the UK and Dr Taranets in complementary mathematical approaches and the application of these unusual combinations of skills to a host of applications that are representative of the many fields in which high-order parabolic systems are now playing a central role. Moreover, ongoing collaborations between the Ukrainian and UK groups will provide a conduit for the continued expansion of the scope of these research activities. The ERA will benefit from proposed fellowship due to access to new approaches and methods for studying nonlinear PDEs.
THE ANDES-NAZCA DYNAMIC TOPOGRAPHY EXPERIMENT (ANDYN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships (Return Phase)
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Argentina
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2013-04-01
End date: 2014-03-31
Duration (months): 12.0
Total project cost (EUR): 15000.0
EU funding (EUR): 15000.0
Participants: 1
Project status: CLOSED

In the world, there is a relative paucity of studies that correlate surface data with deep Earth processes. The main objective of this experiment is to introduce a series of observations from geology (basins, thrust belts and plateaus) to constrain mantle flow models and better understand the topographic signal generated by the mantle. We propose to test an active and natural laboratory: The Andes. The study will embrace the Andean history from Miocene to Present, the main orogenic phase of South America, and from the Amazonian foreland to Patagonia. In these regions, mismatches between orogen dynamics and basin geometries suggests mantle generated topography is an important factor. Understanding the sources of dynamic topography, its amplitude and wavelength and how they vary as the tectonic environment changes (subduction angle and rheology) will help to understand continental wavelength geoid anomalies and surface deflections, as well as large-scale basin subsidence and surface uplift, not only in the Andes but also in orogens with similar origin. I will conduct a series of regional 3-D mantle flow finite element simulations to predict surface deformation and compare to observational geophysics, lithospheric modeling (eg. residual topography) and geological data. Geology will focus on basin analyses (stratigraphy, structural reconstructions, thermo-/geo-chronology, backstripping and flexural models), supported by a compilation and reprocessing of geophysical observations (industry seismic sections, InSAR, GPS, tomography, and gravity). This study will produce databases of international interest for applied and scientific fields.