Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Research, Demonstration, and Commercialisation of DC Microgrid Technologies (RDC2MT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: China,Switzerland,Netherlands,Netherlands,United Kingdom,United Kingdom,Canada,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-02-01
End date: 2022-01-31
Duration (months): 60.0
Total project cost (EUR): 445500.0
EU funding (EUR): 279000.0
Participants: 11
Project status: CLOSED

RDC2MT is a unique five-year research exchanges and networking programme that aims to address new challenges of DC microgrids and to disseminate successful demonstrations of DC powered houses and DC distribution networks. Current research in this field has been fragmented, both disciplinarily and geographically. RDC2MT is a first-of-a-kind project bringing together unique and complementary expertise from 11 international leading research groups in the Europe (UK, Netherlands, and Switzerland), Asia (China) and North America (Canada). RDC2MT will build upon the experience, knowledge and facility gained from ongoing funded projects within the consortium, of an equivalent of 10 million Euros. RDC2MT will be the catalyst to enable the synergy and strong links among the major research and innovation investments that will allow the individual research projects to expand even further. This will be done by dealing with a unique set of challenges across multi-scales, going from fuel cell electrochemistry at molecular scale to microgrid optimizations at system level, through coherent multidisciplinary, inter-sectoral and international collaborations. It will enable knowledge transfer and sharing between project partners, establish long term collaborations, and maximize research impacts.

Keywords: dc microgrid,communication,stabilisation,fuel cells,optimisation,demostration
Access to Risk Finance and SMEs NCP cooperation network (ACCESS4SMES)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Austria,Spain,Ireland,Israel,Germany,Italy,Bulgaria,Norway,Greece,Poland,France,Portugal,Portugal
Call: Capacity-building for National Contact Points (NCPs) for SMEs and Access to Risk Finance under Horizon 2020 (H2020-INNOSUP-06-2016, 2016)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 2047131.25
EU funding (EUR): 2047131.0
Participants: 14
Project status: CLOSED

The main objective of this action is to empower the network of National Contact Points (NCP) for Small medium-sized enterprises - SMEs and Access to risk finance (SMEs, ARF) under Horizon2020, by promoting a systemic service and knowledge provider for SMEs, industry and ARF community. Such knowledge and service provider will include collaboration and networking with relevant networks in thematic areas across the three Pillars of Horizon 2020, as well as networks focusing on SMEs such as the Enterprise Europe Network - EEN. Special attention will be dedicated to strengthening the knowledge of less experienced NCPs from Member States (MS) and Associated Countries (AC) in order to deliver professional cross borders know-how including the EU, National and regional level The Network will address the real needs of European SMEs and industry, notably newcomers , established in the MS and AC with a view on stimulating, encouraging and facilitating a more effective participation of European companies into the several funding opportunities included in Horizon 2020.

Keywords: national contact points,innovation in smes,access to risk finance
Oat CHRomosome Evolution and drivers enabling widespread terminal intergenomic translocations in polyploid species (OCHRE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-10-28
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Comparative genetic analysis of grasses, one of the most widely distributed plant families and including the three most important human foods, has demonstrated that different groups differ in the evolutionary presence of intergenomic chromosome translocations in polyploid species, including the important crops. The overall goal of our research group is to define the nature and mechanism of terminal intergenomic translocations in oats (Avena) where these are frequent, allowing us to model their contribution to cereal genome evolution. We hypothesize that terminal translocations between oat genomes are related to transposable element activity, a decrease in DNA methylation, and histone modifications that are differential between the genomes. We propose a focused series of complementary molecular cytogenetic, bioinformatic, and epigenetic studies on oat and wheat genomes to characterize this physical genome rearrangement process. A comprehensive model illustrating the potential mechanisms involved in terminal intergenomic translocations will be elucidated by the simultaneous hybridization with the use of genome-specific probes and retrotransposon sequences, and immunostaining of histones and 5-methylcytosine in mitotic cells. The research will reveal why genomes of oats show frequent intergenomic translocations, playing a significant role in their evolution, in contrast to wheats where the translocations are rare. The fundamental research has implications for breeding oats to exploit biodiversity through introgression from wild species, and perhaps enabling additional introgressions in wheat breeding.

Keywords: evolution,translocations,repetitive dna,retrotransposons
A General Strategy for the Iterative Assembly of Complex 1,3-Polyol Motifs (GRITAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

An attractive approach to preparing molecules with common repeat units is iterative synthesis, an approach that is extensively used by Nature in the synthesis of large biomolecules. Nature also uses this tactic for small-molecule synthesis even though common repeat units are not always immediately apparent, the archetypical example being polyketide synthesis. In contrast, iterative strategies in chemical synthesis are often much less efficient requiring several functional-group interconversions and purifications between chain-extension steps. We recently reported an “Assembly Line Synthesis” method for the iterative, reagent-controlled homologation (chain extension) of a boronic ester. This process enabled the conversion of a simple boronic ester into a molecule bearing 10 contiguous methyl substituents in an effectively “one-pot” process. Whilst these methyl-rich carbon chains are rare in natural products, hydroxyl-rich carbon chains (1,3-polyols) are ubiquitous and often show pronounced and useful biological activity. It would therefore be very useful if this or a related strategy could be applied to the fully stereocontrolled synthesis of 1,3-polyols. Herein, we outline a general strategy for the synthesis of 1,3-polyols that hinges on the merging of two well-established methodologies: lithiation–borylation and catalytic diboration. We expect to achieve complete control over both relative and absolute stereochemistry in the iterative synthesis of 1,3-polyboronic esters, enabling stereochemistry to be essentially dialled-in. Subsequent oxidation of the boron esters reveals the desired 1,3-related polyol. The strategy will be applied to the total synthesis of one of the most complex polyols known, bahamaolide A, a macrocyclic polyol–polyene natural product with potent antifungal properties. This strategy promises to be the most efficient synthetic route to these highly biologically active and hugely important class of compounds.

Keywords: boron,stereoselective,polyol,total synthesis,polyketide
Dynamic Algorithms Against Strong Adversaries (DynASoAr)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-09-01
End date: 2026-08-31
Duration (months): 60.0
Total project cost (EUR): 1499843.0
EU funding (EUR): 1499843.0
Participants: 1
Project status: SIGNED

From a procedural viewpoint, an algorithm is a list of instructions that transforms a given input into the desired output. While this paradigm has been successfully applied in theory and practice, it completely neglects the fact that in many scenarios the input is not given to the algorithm in its entirety at the beginning and might undergo changes that the algorithm needs to react to. Formally, such a situation can be modeled as a game between an adversary creating the sequence of updates to the input and an algorithm that tries to process each of these updates as fast as possible. Researchers have studied such dynamic problems with increasing interest in the past years. However, many state-of-the-art solutions suffer from at least one of the following drawbacks: (1) Many dynamic algorithms are randomized and assume that the sequence of updates is independent of the random choices made by the algorithm. This is not justified in situations where the next update to the input naturally depends on the previous outputs of the algorithm. (2) Many dynamic algorithms achieve amortized running time guarantees where the stated guarantee on processing each update only holds on average and occasionally significantly more time might be needed. This is insufficient for real-time systems requiring hard worst-case guarantees. The goal of this project is to design dynamic algorithms free from these two shortcomings. Formally, this amounts to giving the adversary the following additional powers: (1) adapting its update sequence to the outputs of the algorithm and (2) discarding the algorithm if some update is not processed in time. While isolated results in this direction exist, with some of them obtained by the PI, the unique feature of this project is the systematic study of these stronger adversarial models for otherwise well-studied dynamic problems. Our results will facilitate the use of dynamic algorithms in both real-world applications and in the design of static algorithms.

Keywords: efficient algorithms,dynamic graph algorithms
Investigating the Human Mycobolome through Uniting Large-scale Epidemiological and Mechanistic Poly-omic Designs (HUMYCO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2020-12-01
End date: 2025-11-30
Duration (months): 60.0
Total project cost (EUR): 1498750.0
EU funding (EUR): 1498750.0
Participants: 1
Project status: SIGNED

Mycotoxins, toxic fungal secondary metabolites, known to be the most hazardous of all food contaminants in terms of chronic toxicity, have the potential to contribute to a diversity of adverse health effects in humans, and are unfortunately ubiquitously present in our daily diet. Chronic low-dose intake of multiple mycotoxins are hypothesized to be associated with an increased risk of developing human renal, colorectal and hepatocellular carcinomas. HUMYCO refers to a unique, holistic & multi(cross)-disciplinary research field, aiming at comprehensively investigating the human mycobolome through uniting large-scale epidemiological & mechanistic designs using a poly-omic approach. Focus is set to generate newly hypotheses-driven insights into the role of multiple mycotoxin exposure in the aetiology of human carcinomas. The capability of conducting accurate exposure assessments of mycotoxins at the individual-level is required to fully understand the potential health consequences in humans, therefore, mycotoxin biomarkers of exposure will be primarily identified in vitro, and validated using human intervention studies by elucidating human mycotoxicokinetic profiles via metabolomics. The nature and extent of associations between estimated external and internal dietary multiple mycotoxin exposures and developing renal, colorectal and hepatocellular carcinomas will be investigated through large-scale epidemiological bio-cohorts, established in both Europe and Africa. To further disentangle possible associative mycotoxin-induced cancer development, causal relations will be verified through an innovative mechanistic arm applying advanced cutting-edged technologies. For the first time, genome-wide mutation spectra associated with multi-exposure to putatively carcinogenic mycotoxins will be experimentally determined. HUMYCO contributes to dietary-based human health prevention by identification of specific cancer risks related to multiple mycotoxins exposure.

Keywords: mycotoxins,dietary exposure,cancer,public health,europe,africa
Communication Systems for Next-generation Railways (MISTRAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Germany,Italy,Spain,Italy
Call: Technical specifications for a new Adaptable Communication system for all Railways. (H2020-S2RJU-OC-2015-01-2, 2015)
Start date: 2016-11-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 499282.5
EU funding (EUR): 499282.5
Participants: 5
Project status: CLOSED

MISTRAL will elaborate the Technical Specification of the future communication system for all railways in light of the migration from the current obsolete GSM-R.The new radio system will leverage the broadband capacity of IP-based wireless communication to enhance signaling but also to make possible innovative services for both users and train automation/control.To achieve the objective, MISTRAL will generate firstly a portfolio of foreseeable future communication scenarios. Then, a Techno-Economic Proposition consistent with future scenarios will be defined, including a portfolio of innovative services ushered-in by new technologies and compliant with new users requirements as well as with safety, security and QoS requirements. Such Techno-Economic proposition will be subject to a Business Viability Analysis - meant to gauge and optimize the total-cost-of-ownership of the new communication system - and to a Technical Viability Analysis that will investigate the compliance with the new requirements. Subsequently, the results of such Business and Technical Viability Analysis will be used as basis to refine and finalize the Validated Techno-Economic proposition, which will thus rely on an optimized life-cycle cost and on a sound portfolio of innovative services. The Validated Techno-Economic proposition will be the main output of MISTRAL, i.e. the 'Technical Specification' scope of the topic. Its design and validation will be supported by an External Stakeholder Committee, involving selected key players in the Railway domain, external to the MISTRAL Consortium. In addition, MISTRAL will disseminate project findings to relevant stakeholders and communities and will ensure the sustainability and impact of the new specified communication system, In terms of far-reaching impact, MISTRAL will lay the foundations for the next-generation train-to-wayside communication systems, paving the way for a more competitive, attractive and sustainable European railway ecosystem.

Keywords: business model scenarios conditions for use of public communication qos
Boosting motor learning through sleep and targeted memory reactivation in ageing and Parkinson’s disease (TARGET SLEEP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

Rehabilitation is an important therapeutic strategy for patients with Parkinson’s disease (PD), whereby motor adaptations are learned to maintain daily functioning. However, patients often present difficulty consolidating newly learned skills into long-term memory, which reduces the benefits of training. Interventions that enhance consolidation are therefore projected to diminish the impact of PD. Sleep facilitates motor memory consolidation in healthy adults, especially in combination with targeted memory reactivation (TMR). TMR works by adding associated auditory stimuli during learning, which are replayed during sleep and thus reinforce the recently formed neural connections. Importantly, recent work has suggested that consolidation during sleep may be preserved in PD, but robust findings are lacking and have not involved TMR. This knowledge gap is astonishing given the potential benefits that can be gained by integrating sleep interventions into rehabilitation. My objective is to address this imperative by investigating the effect of sleep on motor memory consolidation by experimentally manipulating exposure to sleep and TMR for the first time. Concretely, I will compare the effect of a 2-hour daytime nap with or without TMR to that of a wake control period in PD and age-matched controls. I will use a validated motor sequence task to test for behavioral markers of motor learning and apply state-of-the-art neuroimaging techniques to study the imprint of neural network changes underlying consolidation. My training objectives include teaching and supervising students in rehabilitation–related neuroscientific topics and research leadership development. I will also implement a rigorous dissemination and communication plan to achieve optimal societal impact of my research findings. I anticipate my MSCA to spark new sleep interventions that boost the effectiveness of rehabilitation and improve the wellbeing of our ageing population, in particular those affected by PD.

Keywords: consolidation,rehabilitation
A technological solution for the 50 billion EUR VAT fraud problem (TXpp)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Tax Authorities and factoring agencies in the EU are the victim of billions of Euros in invoicing fraud every year, and there has not yet been any good solution in sight. Until now. There were many attempts to solve the problem but none achieved consensus amongst all EU Member States. This tremendous societal problem is back in the focus of Member States and the European Commission. We solve this problem once and for all by creating a single source of truth for invoices. Tax Authorities will use our innovative blockchain protocol to let companies register invoices for VAT purposes. We will not only safeguard billions of Euros in VAT, but we will also create the biggest verified invoice registration network in the world. We were honoured to present our findings at the EU blockchain forum to members from DG HOME, AGRI, JUST and DIGIT (https://youtu.be/hPQXkQs7njg?t=3370). More importantly, DG-TAXUD also invited us to present for a select group of VAT experts. Our model is easily scalable within the EU due to the harmonized VAT law and the fact that VAT fraud prevention works the same in different Member States. This data can be used for more than just VAT registrations: we will give companies of all sizes access to commercial applications like factoring. In contrast to existing ideas to tackle VAT fraud, our solution offers privacy-by-design, it provides benefits to companies, and it can be implemented country-by-country. All reasons why we already 1) secured a cooperation with a Ministry to run a pilot 2) secured funding for our operations in the Netherlands. For both stakeholders we appended their letters of intent. As we ensure every single invoice can be used for various business processes, we do not only innovate, but disrupt markets. Both the increase in government revenues because of the enormous reduction in VAT fraud and the increase in efficiency of business processes will increase economic growth and create jobs throughout the EU.

Keywords: invoice,factoring,auditing,fintech,regtech,blockchain,cybersecurity,security,government revenue,fraud prevention,privacy by design