Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DECiphering the role of long non COding Rna in cancer (DECODER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2011-11-01
End date: 2014-10-31
Duration (months): 36.0
Total project cost (EUR): 236442.4
EU funding (EUR): 236442.4
Participants: 1
Project status: CLOSED

Increasing evidence indicates that non coding RNAs play a major role in the regulation of gene expression. A significant fraction of the non-coding transcriptome is represented by large intervening non coding RNA (lincRNAs), which seem to be involved with the epigenetic control of gene expression through binding with several members of the Polycomb Repressive Complexes (PRCs). Recently, dysregulation of lincRNAs has been associated to cancer. The HOTAIR lincRNA triggers the invasive program of breast epithelial cells by promoting epigenetic remodelling (Gupta et al., 2010). Although this report suggests an impact of lincRNAs in the transition to the metastatic phenotype, the role of lincRNAs in transformation remains largely unexplored. In this project I want to define the role of lincRNAs in the pathogenesis of cancer, using acute promyelocytic leukaemia (APL) as a model system. APL accounts for more than 10% of all Acute Myeloid Leukemias and is characterized by reciprocal translocations involving the retinoic acid α-receptor (RARα). APL blasts respond to all-trans retinoic acid (ATRA) treatment with differentiation, which involves epigenetic remodelling. The availability of new sequencing technologies coupled to tiling arrays and to the power of new computational biology programs, makes it now possible to study the whole non–coding RNA transcriptome. Determining the pattern of expression of lincRNAs during ATRA-induced APL differentiation, defining their functional significance, and deciphering the network of interactions between lincRNAs, the PML-RARα chimeric protein and the PRCs, will contribute to a better understanding of the nature of epigenetic deregulation in cancer and ultimately represent the basis to develop new anti-cancer strategies.

Keywords: long non coding rnas,acute promyelocytic leukemia,cancer epigenetics,non coding transcriptome
ENtanglement renormalization and GAuGE Symmetry (ENGAGES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-05-01
End date: 2013-04-30
Duration (months): 24.0
Total project cost (EUR): 168180.8
EU funding (EUR): 168180.8
Participants: 1
Project status: CLOSED

Recent progress in studying Entanglement Renormalization (ER) in the context of quantum information has led to a powerful ansatz to describe wave functions of complex quantum many-body systems. Dr. Tagliacozzo intends, with this project, to apply this ansatz to study Lattice Gauge Theories (LGT). LGT are relevant to different branches of physics: a) they constitute one of the few tools available to analyze the strongly coupled regime of Quantum Chromo Dynamics b) they play a prominent role in effective models for quantum material's antiferromagnetism and high temperature superconductivity; c) their phase diagrams are related to the stability of topological phases relevant for quantum computation. Present approaches to study LGT are mostly based on Monte Carlo (MC) simulations that incur in several limitations: 1) difficulty to directly extract information about quantum states wave functions such as their entanglement entropy or the expected value of non-local observables; 2) exponentially hard simulations of fermionic and frustrated systems; 3) very limited ability to perform time evolutions. These limitations prevent our complete understanding of LGT. By applying ER directly to the LGT Hamiltonian formulation, Dr. Tagliacozzo will provide new computational tools to override these limitations and gain access to: 1) scaling of the entanglement entropy and non local observables and fidelities, 2) simulations of LGT with either bosonic or fermionic matter and of frustrated LGT at the same computational cost; 3) time evolutions. In order to succeed with his objectives the candidate will have: 1) to expand the current theoretical framework of ER so that it can be applied to a LGT following his seminal paper; 2) develop the related numerical tools, 3) deploy them in massive simulations. The information the candidate will gather with his project will complement the current understanding of LGT based on MC simulations providing better insight of LGT in 2+1 dimensions.

Keywords: entanglement,strongly correlated many body quantum systems,renormalization group,tensor network,toplogical order,gauge theories,quantum field theories,computational physics,statistical physics
Coupled model simulations of global climate, terrestrial biosphere and atmospheric composition focused on global and European air quality (CLIMBAIR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-03-12
End date: 2014-03-11
Duration (months): 24.0
Total project cost (EUR): 176185.6
EU funding (EUR): 176185.6
Participants: 1
Project status: CLOSED

Interconnections between climate, vegetation and air composition are emerging as a central topic with important consequences for projections of future climate and air quality (AQ), both on global and regional scales. Yet the number of studies and models incorporating all these components together is limited, and especially the role played by vegetation-climate interactions is not well understood. This project will assess the impact of climate change and the associated response of the terrestrial biosphere on global atmospheric composition, with particular focus on European AQ. CLIMBAIR will use the state-of-the-art European Earth system model (ESM) EC-Earth to represent climate, air composition and terrestrial biosphere processes in an integrated way. The experiments will be carried out on a global scale with increased resolution over Europe, thanks to the two-way nested zoom option available in the chemistry-transport model (CTM) embedded in EC-Earth. CLIMBAIR will provide future estimates of AQ, to be used by collaboration partners for regional modelling studies, and to advise authorities and stakeholders on adaptation of European policies to mitigate climate change impacts on AQ. The project will also advance the development of the European ESM. CLIMBAIR will contribute to the integration of the interactive vegetation module, and will evaluate its impacts on the simulation of future AQ. Separate impacts from biogenic emissions and wildfires will be considered. The potential of future global land use management to mitigate climate impacts on AQ will also be explored in this project. The leading role played by the host organisation in the EC-Earth consortium, and the fellow’s experience with CTMs and the general circulation model (GCM) used in EC-Earth, will ensure high quality research and high impact dissemination of results. The CLIMBAIR project will also contribute to broaden the fellow’s experience towards her next career stage.

Keywords: atmospheric chemistry (climate change),atmospheric pollution (climate change),ozone and atmospheric composition,biogeochemistry (climate change),climate modelling (climate change)
BLADE TIP TIMING MEASUREMENT TECHNIQUE FOR TURBINE MONITORING IN WORKING CONDITIONS (BTTMON)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-01-16
End date: 2013-07-15
Duration (months): 18.0
Total project cost (EUR): 171650.0
EU funding (EUR): 171650.0
Participants: 1
Project status: CLOSED

Blade tip timing measurement technique (BTT) is a new growing measurement technology for non contact measurements of turbine blade vibrations during operation, fundamentals for performancies evaluation of under development aircraft engines, steam and gas turbine for power generation, and other industrial turbomachines. It is now becomed a valid alternative to classical strain gauge measurement technique for fatigue life prediction, vibration analysis, reliability and safety assesment. The possibility to use BTT measurement techniques for turbine monitorig during operation is actually a scientific and technological challange, never used till now, that could have a strong impact in turbine maintenance optimization, reliability and safety, therefore in aircaraft and power generation plant safety, reliability improvments and operating cost reduction. This proposal, by the study and development of new modelling techniques, new data processing methods, new sensors and calibration techniques has the goal to go in this direction.

Keywords: technological sciences
UNCONVENTIONAL SUPERCONDUCTORS: FROM SYNTHESIS TO UNDERSTANDING (USSU)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-11-07
End date: 2013-11-06
Duration (months): 24.0
Total project cost (EUR): 185748.0
EU funding (EUR): 185748.0
Participants: 1
Project status: CLOSED

The main scientific aim of the proposed research program is to study the physical properties of unconventional superconductors, in particular those with high superconducting transition temperatures (cuprates and iron-pnictides). The key issues are addressed through intensive team work and a bottom-up approach. This begins with the synthesis and careful characterization of single crystals, continues with the application of advanced experimental probes, and culminates in a rationalization of the obtained experimental results with state-of-the-art theoretical concepts. The research will be devoted to studying the relationships between Tc and different structural parameters, the role of disorder and the electronic structure of iron-pnictides. The latter will be determined by comparing optical conductivity results with the Hall Effect and ARPES data. In addition to classifying the symmetry of the superconducting order parameter, a microscopic understanding of (incommensurate) magnetism will be sought by the application of complementary probes such as Mossbauer, NMR and neutron diffraction. Other pertinent questions related to the magnetic pseudogap, charge-lattice deformation entanglement and superconducting fluctuations will also be carefully addressed. An interesting prospect to investigate for both classes of materials is that the superconductivity develops from a Fermi liquid, which, if proven correct, would be unconventional for strongly correlated electron systems. The originality of the project lies in its multidisciplinary nature. It has been designed to establish an active synergy between material syntheses and advanced experimental techniques in the investigation of a cutting edge physical problem. Similarly, it succeeds in matching a well-qualified applicant with a top-class European institution. As such it delivers important new skills and experience to the candidate and primes him for a successful independent career within the European Research Area.

Keywords: natural sciences,superconductivity,cuprates,iron-pnictides,synthesis,characterization,multidisciplinarity,complementary experiments,electronic structure,fermi liquid,magnetism,fluctuations
TECHNOLOGY OF THE LAST FORAGERS AND FIRST FARMERS IN THE BALKANS (MESO-NEO TECHNOLOGY)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-10-01
End date: 2013-09-30
Duration (months): 24.0
Total project cost (EUR): 209592.8
EU funding (EUR): 209592.8
Participants: 1
Project status: CLOSED

This project is aimed to clarify the technology of the last foragers and the first farmers in the Balkan Peninsula. The mechanisms of (a) postglacial adaptations to a particular environmental setting along the eastern Adriatic coast (Istria and central Dalmatia) and along the River Danube from the Epipalaeolithic (c. 13,000-10,000 BC) throughout Early-Late Mesolithic (c. 10,000-6300 cal. BC); and (b) consequences of contact between two different technological traditions in these regions due to the interactions between foragers and farmers in the period after around 6200/6000 cal. BC will be investigated. The selected geographic areas are the hot spots for studying the spread of agriculture in Europe that have recently either yielded archaeological evidence from new sites or seen improvements in the quality of the existing datasets through the application of archaeometric approaches. The research objectives will be achieved through analyses of technological and functional features that relate to the production and use of osseous and knapped stone tools as well as ornaments. These classes of artefacts have been understudied in the research on postglacial adaptations as well as Mesolithic-Neolithic interactions for the regions. Furthermore they have been considered separately although their use could be part of the same techno-functional adaptive process. The methodology of the research will be based on the integration of analytical and theoretical approaches to the study of material culture which involves analyses of: i) technological and use-wear traces, ii) interpretation of archaeological residues, iii) experimental activity, iv) construction of a theoretical framework based on social anthropological theory and v) a wider perspective on Mesolithic adaptations and Mesolithic-Neolithic transformations in Europe. This work should set a standard for future studies of osseous and knapped stone industries in the region.

Keywords: prehistoric technology,last foragers,first farmers,balkan peninsula,tools function,experimental archaeology,residues analysis,mesolithic-neolithic transition,stone and bone tools,ornaments
Regulation of iron-sulfur (Fe-S) cluster assembly in plastids and coordination with plant physiology. (INTEGRREGULFESPLAST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2011-06-01
End date: 2014-05-31
Duration (months): 36.0
Total project cost (EUR): 239034.4
EU funding (EUR): 239034.4
Participants: 1
Project status: CLOSED

Pivotal to the essential plant process of photosynthesis, which determines crop productivity, are iron-sulfur (Fe-S) cofactors. My outgoing phase host, Dr. Pilon at Colorado State University (USA), played a major role in defining the core components of the chloroplast Fe-S cluster assembly machinery essential for photosynthesis. Using an integrated biochemical-physiological-genetic approach in the model plant Arabidopsis thaliana I aim to investigate how the machinery components interact to produce Fe-S clusters, and how assembly is regulated. Specifically, I will study protein-protein interactions that mediate Fe-S assembly and use inducible RNA interference to create conditional loss-of-function mutants for individual components. This will also train me in methods developed in Dr. Pilon’s group: affinity purification, protein-protein interaction, in vitro reconstitution and RNAi. I will use these tools and skills in the return phase in the group of Dr. Gaymard in Montpellier (France) where I will establish a model for regulation of Fe-S assembly. Using the state of the art high-throughput “Phenopsis” platform I will study Fe-S assembly in the various mutant plant lines and investigate its response to changing environmental conditions, and stresses that limit agricultural productivity. This innovative project will provide basic knowledge and have additional impact for the breeding of more productive, nutritious plants. The importance of iron for food production and quality, key areas in the EU, cannot be overstated. This fellowship will contribute to European excellence and mobility via training, knowledge transfer and implementation of integrated methods. The project provides mentoring and management training; further complementary skills training is ensured by the highly interactive environments of both host labs at premier research institutes. The proposed project will provide excellent professional preparation for a group leader in the post-genomic era.

Keywords: fe-s cluster,chloroplast,plant,a.thaliana,regulation,high-throughput phenotyping,protein interaction
Rare Earth Oxide Dielectrics for Advanced Germanium CMOS Technology (REACT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-05-01
End date: 2013-04-30
Duration (months): 24.0
Total project cost (EUR): 157720.0
EU funding (EUR): 157720.0
Participants: 1
Project status: CLOSED

The training activities will cover the area of advanced CMOS with special attention on suitable gate dielectrics for high carrier mobility germanium substrates. Since strained Si, especially for nMOS, is running out of steam, high mobility channels could be an alternative option for future 11 nm node and beyond. A Ge CMOS is preferable due to processing simplicity in a Si-compatible flow, however it has remained elusive for several years due to the underperformance of nMOS transistors. During the last year, a large progress in Ge nMOSFETs has been observed which gave new momentum to this field. The key enabler for the success is the development of a good quality thick GeO2 gate dielectric which however is not scalable. In this project, we will look for alternative passivating layer/gate dielectric stacks based on rare earth oxides which have equal or better quality when compared to GeO2 but also a better scalability to EOT values close to 1 nm fulfilling the technology requirements. Starting from La as a model material, we will extend our studies to other rare earth elements to show that rare earths modify drastically the Ge surface chemistry during oxidation and by forming stable germanates suppress interface defects and GeO volatilization maintaining high integrity dielectric/Ge interfaces. The fellowship will strengthen the already existing expertise and reputation of the host institution on Ge technology and will help the fellow to expand his knowledge and skills into an area of importance for the industry, giving him the opportunity for a career at a later stage in the semiconductor industry.

Keywords: technological sciences,physical sciences,materials engineering
Intimate coupling of biological advanced oxidation processes for environmental de-pollution and biodiesel production (BIOAOPBDIES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-02-01
End date: 2014-01-31
Duration (months): 24.0
Total project cost (EUR): 167065.6
EU funding (EUR): 167065.6
Participants: 1
Project status: CLOSED

This project aims on the development of novel environmental friendly technologies with two main objectives: a) the removal of recalcitrant pollutants and b) the concomitant production of biodiesel. The goals will be achieved by the coupling of “biological” and “advanced oxidation processes” in order to enhance the removal of stable environmental pollutants and the utilization of the biomass developed for biodiesel production. Many of the technologies applied for the removal of environmental pollutants are not effective either due to the fact that they are not environmental friendly or due to their inefficacy on the removal of recalcitrant pollutants such as pharmaceutical and personal care products. Here, advanced oxidation processes coupled with biological systems (ABOP) will be applied. This is an environmental friendly technology and highly effective on the decomposition of poorly biodegradable substances. A multi-methodology study will be carried out to explore mechanistic aspects of the procedure involving enzymatic activity, the use of mixed and pure cultures, identification of intermediate oxidation agents and by-products, the effect of mediators etc. In order to fully exploit the “green” potential of this methodology the biomass developed during the degradation of environmental pollutants, which is considered a cheap and reliable source, will be used for biodiesel production. A detail study using suspended growth and attached growth reactors will be performed in order to extract the appropriate conditions to enhance both pollutants degradation and biodiesel production. Both main objectives will be applied in a pilot scale wastewater treatment plant (WWTP). Finally, both main objectives of this project (environmental protection and biofuels production) are essential characteristics of the EU FP7 framework and can easily find industrial application in WWTP. The results are expected to give further insights in both fields, which are novel and yet unexplored.

Keywords: environmental science,chemical engineering,environmental technology,water resources engineering,biodiesel production,advaned bio-oxidation processes,pollutants degradation