Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Scalable manufacturing of bio-inspired & bio-based Graphene Foam components of extreme performance (Bio.3DGREEN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Germany,Spain,United Kingdom,Greece,Cyprus,Belgium,Italy,Denmark,Switzerland
Call: Bio-intelligent manufacturing industries (Made in Europe Partnership) (RIA) (HORIZON-CL4-2024-TWIN-TRANSITION-01-TWO-STAGE, 2024)
Start date: 2025-05-01
End date: 2028-10-31
Duration (months): 42.0
Total project cost (EUR): 6156871.13
EU funding (EUR): 4999645.67
Participants: 14
Project status: SIGNED

Nature uses foam or sponge-like structures in various organisms for purposes like shock absorption, noise reduction, and vibration compensation in a remarkable example of evolutionary adaptation and functional design. On the other hand, many products still rely on non-sustainable materials of fossil-based origin, for example foams and elastomeric used for vibratory motion, sound, harshness, energy, and shock-impact absorption in industries such as automotive, aerospace and marine. Example of such Noise Vibration and Harshness (NVH) materials are rubber and engineering resins. Bio.3DGREEN develops and demonstrates a novel manufacturing approach for a cost-effective bio-inspired platform of bio-based components based on graphene foam (GF) to meet the industrial needs, i.e. vibration, sound and shock-impact absorption and durability in extreme conditions. Bio.3DGREEN democratizes graphene technology and enables the unscalable fabrication of graphene-based components of complex geometries to be demonstrated at TRL 6 through a high throughput, laser-based Additive Manufacturing (AM) procedure. The procedure is bio-inspired, mimicking structures such as the human bone, and is based solely on bio-based graphene system with vegetable oil as the raw material, resulting in carbon-positive manufacturing of the new components. Bio.3DGREEN demonstrates the superior bio-based GF parts in four different industries, aiming to drive the optimization of the new manufacturing approach through an application-driven approach: Automotive suspension systems & isolation panels, aerospace applications and quiet shipping. Bio.3DGREEN achieves a multi-disciplinary approach to develop, optimize, and improve smart manufacturing application-driven, bio-based GF components, also considering the performance of current materials used, their cost, market size, wastage and recyclability, sustainability of manufacturing process, inclusion in Europe’s circular economy and LCA, LCC aspects.

Keywords: graphene,graphene foam,graphene sponge,additive manufacturing,biomaterials,bio inspired,fossil based alternative,laser processing
All-acoustic Bubble Microrheology for rapid screening of formulations (ABuMic)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands,Italy
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2022-07-01
End date: 2023-12-31
Duration (months): 18.0
Total project cost (EUR): 162857.14
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

ABuMic aims to address a critical challenge of our society: the transition of formulated products to a safer and more sustainable industry. There is increasing pressure on the industry, both from the public opinion and regulatory bodies, for healthier food products and more environmentally friendly paints and coatings. As a result, in the coming years many formulated products will need to be re-formulated. This will come at a huge cost for the industry, because by and large, product development is still done by trial-and-error. This means that the formulated products industry needs more than ever the capability to predict formulation performance for rapid screening of new products. The current challenge is that processing flows and end-use produce flow conditions that are not accessible with existing methods for materials characterization. With the ABuMic device, a formulation scientist will be able to design a new product more quickly and efficiently, thereby lowering the cost of new product development, and supporting the transition to healthier and more sustainable products.
Dosimetry of Ultra-High Dose-Rate Electron Beams at Solid-Water Interfaces in Electron Microscopy: A Key Advance in Hydrated Samples Research (DREAM-SWIM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 2130686.0
EU funding (EUR): 2130686.0
Participants: 1
Project status: SIGNED

Electron microscopy (EM) has played a key role in the discovery of many new materials, as well as the elucidation of the role of defect structures and interfaces on material properties and behaviour. Current electron microscopes are capable of maintaining the relevant hydrated state of samples by means of cryofixation techniques or by using dedicated liquid cells. This opens up the possibility of investigating crucial interfaces, such as those in complex aqueous systems that, despite their significance, remain poorly understood. The study of water-solid interfaces in the EM is currently limited by the sensitivity of aqueous samples and interfaces to the action of the electron beam. Knowledge of the fundamental chemical processes induced by interaction with the electron beam is needed for the interpretation of results, prediction and design of experiments and to potentially mitigate electron-beam effects. Here, I propose to develop novel instrumentation and approaches to allow for the direct determination of the yields of radicals and molecules produced as well as reaction kinetics in the EM and at the interface between materials and aqueous solutions. This new concept will permit us to precisely assess the effect of important factors in the radiolysis of aqueous solutions inside the EM such as the very high electron dose rates, the supports, liquid volume, temperature or the effect of nanomaterials’ interfaces. This newly accessible knowledge will lead to the interpretation of numerous EM experiments and will be used to develop novel data-informed adaptive scanning approaches specifically designed for in situ dynamic acquisition with minimal chemical effects in the samples. An important goal of this project is to conceive new predictive models for the radiolytic chemistry produced during EM experiments, which will open the door to the future design of mitigation procedures for radiolysis damage in EM.

Keywords: radiation damage,liquid cell electron microscopy,liquid phase electron microscopy,cryo eels
REPHASE: REdox regulation of PHAse separation for plant Adaptation to Stressful Environments (REPHASE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium,Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 2
Project status: SIGNED

The proposed project explores the intriguing possibility of reactive oxygen species (ROS) regulating the formation of stress granules (SGs) during heat stress. Heat stress triggers the rapid accumulation of ROS, with H2O2 playing a pivotal role as a signalling molecule that induces oxidative post-translational modifications (Oxi-PTMs) to regulate protein activities. On the other hand, an increase in temperature leads to the formation of enigmatic droplets in the cytosol known as SGs. These membraneless organelles (MLOs) arise through liquid-liquid phase separation (LLPS), enabling the concentration of proteins, mRNA, and metabolites to facilitate cellular adaptation. ROS accumulation and SGs formation have traditionally been viewed as independent events in the heat stress response. However, recent studies have shed light on the significance of Oxi-PTMs as regulators of protein LLPS in plants. Moreover, my preliminary experiments have demonstrated that the chemical blocking of Oxi-PTMs impairs SG formation during heat stress. I propose that ROS accumulation during heat stress induces Oxi-PTMs on proteins, promoting LLPS and facilitating SG formation. The REPHASE project aims to address this hypothesis through two main objectives. Firstly, I will investigate the dynamics of the redox state within SGs during heat stress. Secondly, I will map the landscape of Oxi-PTMs in SGs shedding light on their distribution and functional implications. To achieve these goals, the fluorescent redox biosensor roGFP2-Orp1 and the proteomic OxiTRAP probe YAP1 will be targeted to SGs. Utilizing these innovative methods will enable a comprehensive exploration of the redox biology of SGs, leveraging the state-of-the-art proteomic core and live cell imaging facilities available at the host institute. By bridging the gap between redox signalling and SGs, the REPHASE project promises to provide valuable insights into the mechanisms underlying plant adaptation to environmental stress.

Keywords: redox biology,stress granules,heat stress,arabidopsis,biomolecular condensates
Secured and Intelligent Massive Machine-to-Machine Communications for 6G (SCION)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Türkiye,Sweden,Netherlands,Germany,United Kingdom,Portugal
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-02-01
End date: 2027-07-31
Duration (months): 54.0
Total project cost (EUR): 2148594.17
EU funding (EUR): 1828303.2
Participants: 10
Project status: SIGNED

To satisfy the expected plethora of demanding services, 6G is envisioned as a revolutionary paradigm to carry forward the capacities of enhanced broadband, massive access, and Ultra-reliable and low latency services in 5G wireless networks to a more robust and intelligent level. This move will introduce significant new multidisciplinary research challenges emerging throughout the wireless communication protocol stacks, including the way the mobile network is modelled and deployed. The structure of 6G networks will be highly heterogeneous, densely deployed, and dynamic. Combined with the tight quality of services, such complex architecture will result in the untenability of legacy network operation routines. In response, artificial intelligence (AI), especially machine learning (ML), Semantic Communication and Digital Twin (DT) are emerging as solutions to realize the fully intelligent network orchestration and management. By learning from uncertain and dynamic environments, AI-enabled channel estimation and spectrum management will open up opportunities for bringing the excellent performance of Ultra-broadband techniques into full play. Additionally, challenges brought by Ultra-massive access concerning energy and security can be mitigated by applying AI-based approaches. The overall research objective of the SCION project is to develop and design the network systems for seamless wireless access for Secure and Intelligent Massive Machine-to-Machine Communications for 6G. In addition to technology development, to meet the urgent needs for the future working force of the coming 6G era, this collaborative project will create a training network for Doctoral Candidates who will contribute to the design and implementation of future 6G networks.

Keywords: 6g,digital twin,blockchain,semantic communication,power splitting
Regions and (E)DIHs alliance for AI-at-the-Edge adoption by European Industry 5.0 Manufacturing SMEs (AI REDGIO 5.0)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Italy,Germany,United Kingdom,Belgium,Spain,Romania,Czechia,Denmark,Hungary,Austria,Sweden,Serbia,Cyprus,Luxembourg,Portugal,France,Slovenia,Netherlands
Call: ICT Innovation for Manufacturing Sustainability in SMEs (I4MS2) (Made in Europe Partnership) (IA) (HORIZON-CL4-2022-TWIN-TRANSITION-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 9269060.0
EU funding (EUR): 7462614.0
Participants: 45
Project status: SIGNED

The I4MS program in H2020 has been and is a great success for the Digital Transformation of European Manufacturing SMEs. Phase IV of the program was focussing on DIHs and on highly innovative technologies like Digital Twins and AI. In particular, the AI REGIO Innovation Action developed a virtuous alliance between Regions, DIHs, AI solution providers and Manufacturing SMEs, which is materialised by a new methodology for DIHs service portfolio and customer journey analysis, an AI4EU -oriented toolkit of Data and AI resources, a network of Didactic Factories and their TEchnology and REgulatory SAndboxes (TERESA) and an ecosystem of SME-driven experiments and their Digital Transformation pathways. It is time now to align such important outcomes to the evolution of Manufacturing towards Industry 5.0, the evolution of cloud AI Technologies to AI-at-the-Edge, the evolution of H2020 to Horizon and Digital Europe programmes e.g. to EDIH, Data Spaces and AI TEFs (Testing and Experimentation Facilities) for Manufacturing. Some of the AI REGIO I4MS Phase IV motivations are now evolved: it is time for AI REDGIO 5.0 for keeping momentum of AI technologies adoption in Manufacturing SMEs. AI REDGIO 5.0 aims at renovating and extending the H2020 I4MS AI REGIO alliance between Vanguard EU regions and DIHs for a competitive AI-at-the-Edge Digital Transformation of Industry 5.0 Manufacturing SMEs. AI REGIO outcomes (methods and tools for DIHs governance and cross-DIH collaboration; Data Space and AI for Manufacturing toolkit; Didactic Factories network and TERESA facilities; SME-driven experimentations in 14 Vanguard regions) will be i) extended to the I5.0 principles; ii) enabled by the newest trusted technologies along the edge-to-cloud continuum; iii) supported by European open source hw/sw reference implementations, preserving EU values and ethical principles; iv) interconnected with the EDIH network in DEP as well as with the AI TEF nodes and the Data Spaces deployment program.

Keywords: manufacturing smes digital transformation vanguard initiative ai pilot ai at the edge industry 5 0 human centric resilient and sustainable manufacturing digital innovation hubs
A multi-layered -omics study to understand the dynamics leading to morphological progression in pulmonary fibrosis (MORPHOMICS-IPF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

The aim of this research project is to understand the dynamics within the progressing fibrotic lung to identify biologically meaningly interactions which could serve as treatable targets in the future. Therefore, we will use a spatially resolved study set-up involving multiple layers of cutting-edge -omics technologies wherein the inherent variability will be used as a surrogate for disease progression by in-depth quantification of disease extent using microCT and different staining techniques.

Keywords: pulmonary fibrosis,omics,systems biology
Transcription Factor Gene Therapy for Bradyarrhythmias (TRACTION)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2499968.75
EU funding (EUR): 2499968.0
Participants: 3
Project status: SIGNED

PacingCure has developed BradyTx-01: a novel gene therapy medicinal product (GTMP) to cure life-threatening cardiac pacing dysfunctions by reprogramming cardiomyocytes into pacemaker cells. BradyTx-01 is based on a novel method to optimally control transcription factor overexpression through adeno-associated Virus (AAV) mediated gene transfer. The “biological pacemaker” that is created (1) improves cardiac function, (2) responds to metabolic demand, (3) can be delivered using minimally invasive techniques and (4) potentially lasts a lifetime. In the TRACTION project, PacingCure – together with AUMC – will further optimize AAV-mediated transcription vector gene therapy for pacemaker applications, validating the novel AAV vector technology in mice, pigs and non-human primates. Subsequently, a large-scale manufacturing process will be designed to release the materials that will be used for validating and demonstrating long-term safety and efficacy in porcine studies, thereby establishing preclinical proof-of-concept of BradyTx-01. In parallel, we will validate and optimize the technology-product-market fit of BradyTx-01, and the evolving value propositions will be tested and optimized with relevant stakeholders. We will define the optimal regulatory strategies, perform health technology assessments and develop the optimal business strategy, thereby setting the stage for effective clinical and commercial development of BradyTx-01. Within the TRACTION project, we will take the next steps in our development, while also establishing the optimal strategy for our trajectory towards the clinical stage and commercialization of BradyTx-01. The TRACTION project will thus facilitate the complete transition of PacingCure into a fully operational company with an attractive and investment-ready business proposition.

Keywords: gene therapy medicinal product pacing dysfunctions cardiovascular disease biological pacemakers pacemaker cells cellular reprogramming transgene overexpression adeno associated virus vectors
Brain-wide Criticality and Information Processing (BRAINCIP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

The brain is an adaptive system that efficiently performs unique functions in complex and continuously changing environments. Nearly two decades of empirical observations suggest that the brain self-organizes to operate near criticality, a state located at the border between order and disorder, characterized by peculiar features such as long-range correlations and scale invariance of activity, maximal variability of spatio-temporal patterns, and wide response range to perturbations. Theoretical arguments and numerical models indicate that criticality could support optimal computational capabilities by providing a favorable trade-off between reliability and flexibility needed to achieve collective neural behaviors that underlie complex brain functions. Despite signatures of criticality in brain dynamics across spatial scales and systems, the alleged functional role of criticality in brain functions currently lacks direct in vivo empirical confirmation. In this project we aim to investigate in vivo functional advantages of brain criticality, elucidating the relation between emergent brain-wide critical dynamics and brain functions in Zebrafish larvae. Due to their small size and transparency, Zebrafish remain the only vertebrates permitting whole- brain imaging of neural activity with cellular resolution during behavioral study. To probe the functional role of brain-wide criticality in vivo, we will develop a combined theoretical-experimental approach to follow and perturb in near-real time collective neural dynamics during processing of sensory stimuli—and associated behavioral response—, learning, and memory retrieval, while quantifying function, identifying signatures of criticality, and evaluate the relation with information processing. This will consist of a criticality estimator for the online decoding of neural activity, and a finely tunable closed-loop optogenetic stimulation strategy to drive the system away from criticality and assess its functional role.

Keywords: criticality,avalanches,scaling laws,brain,information processing,whole brain imaging,larval zebrafish,single cell resolution,behavior