Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Coupling multi-Omics and Nano-sims approaches to Study the microbial Uptake of Macro-ALGal biomass from marine environments (CONSUMALG)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 2
Project status: TERMINATED

Macroalgae play essential roles within their ecosystems, as they provide food and habitats for a large diversity of marine organisms. They are also important primary producers, fixing atmospheric CO2 via photosynthesis, thus acting as one of the most important carbon reservoirs in coastal habitats. The degradation of this organic matter is controlled by microbial interactions shaping the global carbon flow within the ocean. By releasing degradation products from algal biomass, heterotrophic marine bacteria provide an important source of nutrients for the whole trophic chain. Additionally, future global changes, especially warming temperatures, are predicted to highly impact macroalgae. These observations raise the importance of better understanding mechanisms associated with the microbial degradation of the algal biomass. However, the different bacterial groups able to initiate algal biomass breakdown or uptake the released degradation products are largely unknown. More importantly, their metabolic activities and their quantitative contributions to carbon fluxes remain a black box, hindering an accurate vision of the marine carbon cycle, and the health of marine ecosystems under global warming. In this context, the CONSUMALG project aims to study the degradation mechanisms associated with the algal model Saccharina latissima, a kelp species known to provide important ecosystem services, but also industrial applications. With this project, a multidisciplinary approach will be developed to trace the carbon flow during the degradation, to obtain a detailed qualitative and quantitative description of the bacterial degraders and associated functions. Following the first objective associated with the development of optimized protocols (WP1), a second one will be dedicated to the early degradation steps during the algal breakdown (WP2), while a third will be dedicated to the algal dissolved organic matter (DOM) uptake from secondary degraders (WP3).

Keywords: macroalgae,kelp,degradation,bacteria,13c multi omics,chemical interactions,metabarcoding,metabolomics,metatranscriptomics,nanosims,sip,microcosms
Curved Optoelectronic System to Monitor Ocular Signals (COSMOS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 2
Project status: CLOSED

COSMOS is a highly multi-disciplinary project that will deliver the first technology for the continuous recording of cell resting membrane potentials. Biological electric fields arise by ion transport across cell membranes and tissues, and represent a crucial cue in guiding cellular differentiation (e.g., stem cells), mutation (e.g., cancer cells), and migration (e.g., wound healing). However, the underlying mechanisms behind these phenomena are yet to be fully discovered. This is because this data is currently hard to access with existing technologies: microelectrode arrays rely on electroporation (i.e. probing the cell membrane with consequent disruption, which makes it challenging to perform prolonged measurements), the patch-clamp method has a low throughput, and novel optical technologies mainly addressed the measurement of action potentials. However, most cells in the human body do not fire action potentials, and they communicate in a narrower electrical range. COSMOS will implement a platform to perform contact-free recordings of membrane potentials by optically mirroring the cell membrane charge. This technology will be first applied in testing corneal regenerative technologies (topical drugs, limbal stem cells, post-corneal transplant monitoring), as corneal wounds are an excellent model to study electric field-regulated cell behavior. COSMOS will provide the technological tool to enable addressing a fundamental scientific question, as well as pave the way towards new diagnostic methods, therapeutic strategies, and in vitro drug testing platforms.

Keywords: bioelectricity,electrophysiological recording,membrane potential,nanofabrication,corneal wound healing,corneal tissue engineering,drug testing,regenerative medicine
Joycenstein: James Joyce, Gertrude Stein, and the modernist coterie. (JOYCENSTEIN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 1
Project status: CLOSED

The aim of this Fellowship is for the researcher, Dr Dr Georgina Nugent-Folan, to develop the professional prowess, high-impact dissemination, advanced training and practical experience commensurate with the role of a leading independent researcher in the EU. The researcher will be based for 24 months at the University of Vienna (UV), supervised by Professor Dr Sylvia Mieszkowski. Research training will be implemented through an interdisciplinary project that conducts the first extended comparative study of the modernist writers James Joyce and Gertrude Stein. The project will compare their styles across all their major works, exploring how their contrasting aesthetics has shaped contemporary understandings of modernism. The project will also investigate the fabled antipathy they harboured towards each other, and how this has influenced subsequent critical engagements with their works. The key output will be the first monograph to be written on Joyce and Stein, but the project will also communicate knowledge to a public audience through appropriate outreach activities. The researcher will access expertise, mentoring, advanced training and gain access to the Vienna Centre for Irish Studies (CIS), the most prestigious centre for Irish Studies on the European continent. Due to its unique position as the host of the CIS, together with the interdisciplinary support and mentorship available from the supervisor, the UV is the best institution in Europe for hosting this project. The researcher will be given the opportunity to disseminate and embed her new research through conferences and a symposium. The resources of the host institution will facilitate development of an interdisciplinary and international academic network, together with career-mentoring. The Fellowship will establish the researcher firmly at the centre of modernist studies, positioning her for a successful ERC Starter Grant application and advancing her career goal of obtaining tenure at an EU university.

Keywords: james joyce,gertrude stein,twentieth century modernist studies,european literary modernism,irish literature,american literature,cultural history
Low radon and low internal radioactivity for dark matter and rare event xenon detectors (LowRad)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 3495575.0
EU funding (EUR): 3495575.0
Participants: 1
Project status: SIGNED

The astrophysical and cosmological evidence that the majority of matter in the universe must consist of exotic dark matter is overwhelming. But it is not yet clear what dark matter really is. Very promising candidates are WIMPs, the detection of which would also solve other pressing questions in particle physics. For the search for WIMPs, liquid xenon-based detectors are by far the most sensitive. The collaborations LZ, XENON and DARWIN joined to build a next generation detector, DARWIN/G3, with a sensitivity limited only by coherent neutrino scattering. Such a detector will not only search for dark matter, but will become an observatory for rare event searches (axions, solar neutrinos, neutrinoless double beta decay, ..). Despite construction in underground laboratories and with further shielding or veto systems for muons or neutrons, the sensitivity of these detectors is limited by radioactive decays within the xenon, especially of the radioactive noble gas isotopes 222Rn and 85Kr, dominating the background of current xenon-based dark matter experiments. In this project we want to push the possibilities of cryogenic distillation to continuously reduce 222Rn and 85Kr to an unprecedented level of 1 atom per 100 mol of xenon (10 mol in case of 85Kr), which will make their background contributions at DARWIN/G3 to be a factor 10 smaller than that of the un-shieldable solar neutrinos. Our cryogenic distillation setups which obtain their cooling power from a novel heat pump concept offers the additional benefit of determining the impurity concentrations in-situ. We will integrate the novel distillation systems with the removal of electronegative impurities and their diagnostics into a compact cleaning system. Within LowRAD we aim to provide a complete quasi loss-less continuous 85Kr removal system ready for DARWIN/G3. In addition, we will explore how several important physics channels would become possible due to the extremely low 222Rn and 85Kr concentrations.

Keywords: dark matter,rare event searches,underground physics,radio poor material,xenon,noble gases
Ethermind Matrix Platform: transforming professional upskilling with AI (Ethermind)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Bulgaria
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 48.0
Total project cost (EUR): 1800000.0
EU funding (EUR): 1800000.0
Participants: 1
Project status: SIGNED

Ethermind introduces an innovative AI-powered learning platform, Matrix, for professional training. With constantly accelerating technological progress, lifelong learning has become an absolute necessity for the majority of employees and, consequently, businesses. Face-to-face training cannot satisfy business needs because of the increasing load on trainers. At the same time, existing online platforms cannot provide a personalized approach which is necessary for efficient learning. Ethermind platform was created to satisfy the training needs of businesses and employees without increasing the training burden. Ethermind presents its AI personas—advanced AI agents powered by large language models (LLMs) and the Retrieval-Augmented Generation (RAG) framework. These agents are designed to answer user queries, engage in meaningful conversations, and pose insightful questions. When combined with Ethermind's proprietary knowledge base, multi-modal conversational capabilities, and extensive customization options, the EM platform stands out as a unique leader in its field. The core technology for the platform has been validated with paying clients as instructor augmentation software. The current project involves upgrading AI personas to the required level of autonomy and improving the usability and security compliance of the platform. With upgraded AI personas and other planned improvements, the Ethermind platform will transform the corporate training market in Europe and become the leading solution for professional upskilling. The Ethermind platform will contribute to the lifelong learning paradigm and help people feel more satisfied at their workplaces, thus producing significant social and economic impact.

Keywords: ai persona,professional upskilling,corporate training,ai driven education,personalized learning
Revolutionising EU Manufacturing Capacity and Capabilities, With Transformative Antisense Oligonucleotide (ASO) Precision Medicines for the Treatment of ALS and Other Neurodegenerative Diseases (NeurAso)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 48.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

QurAlis is a clinical-stage biotechnology company discovering and developing precision medicines including next-generation antisense oligonucleotides (ASOs) for the potential treatment of amyotrophic lateral sclerosis (ALS) and other serious neurodegenerative and neurological diseases. ASOs are short, engineered single-stranded DNA/RNA molecules designed to selectively bind RNA to regulate and modify protein expression to restore affected pathways. QurAlis’ first therapeutic product candidate is QRL-201 for the treatment of ALS, a devastating, progressive, and deadly neurological disease with no cure and a significant unmet need for therapeutic options to slow its progression. QRL-201 is a first-in-class ASO that aims to restore STATHMIN-2 (STMN2) expression in ALS patients. STMN2 is a validated major genetic disease driver in ALS. This restoration significantly decreases disease progression and may potentially reverse the disease, improving patients' quality of life and allowing them to maintain muscle function, independence, and the ability to perform daily activities for a longer duration. QRL-201 has the potential to create a paradigm shift in how ALS is treated – to redefine ALS from a two-to-five-year diagnosis-to-death disease to a manageable disease. QurAlis is investigating QRL-201 in a Phase 1 clinical trial with private equity funding. QurAlis now seeks EIC Accelerator blended finance to support the advancement of the QRL-201 clinical program. This includes the completion of commercial manufacturing and conducting a pivotal clinical trial with the potential for Fast-Track designation. For QRL-201, QurAlis expects to enter the market by 2030 in the EU and the US following completion of the pivotal clinical trial (Q2 2029). Upon commercialisation, QurAlis is estimated to earn cumulative €3.95B from QRL-201 sales in the first five years after market approval.

Keywords: antisense oligonucleotides,neurodegenerative diseases,amyotrophic lateral sclerosis,als
UNLOCKING THE POWER OF INNATE IMMUNITY TO PRESERVE BIODIVERSITY (DalanBio)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Honeybees are essential to global food security and biodiversity, yet they face unprecedented threats from pathogens such as Deformed Wing Virus (DWV-B), which infects 100% of feral and managed colonies and causes colony collapse in less than six months. Despite their critical ecological and economic importance, honeybees currently lack prophylactic or therapeutic solutions for viral diseases. This gap highlights the urgent need for sustainable and scalable disease management solutions to ensure pollinator health and ecosystem stability. Dalan Bio's revolutionary honeybee vaccine harnesses transgenerational immunity (TGIP) to provide queen bees with the ability to pass protective immunity to their offspring. This first-of-its-kind, non-GMO, chemical-free innovation directly targets DWV-B, offering an eco-friendly and effective solution in a field with no currently approved treatments. By 2029, our vaccine is expected to be on the market, on its way to becoming standard operating procedure for beekeepers, protecting pollinator populations and contributing to global food supply chains. Our project spans four years (2025–2029) and includes activities such as vaccine development, preclinical safety and efficacy trials, regulatory dossier preparation, and pre-market field trials in France and Italy. Dalan Bio's unique approach aligns with the One Health framework, addressing interconnected challenges in pollinator health, biodiversity conservation, and sustainable agriculture. With support from the EIC, Dalan Bio aims to finalize its innovative vaccine, develop vaccination methods to fit the European market, expand manufacturing capacity, and establish a robust market presence. This funding will enable us to deliver a transformative solution to the EU market, safeguarding pollinators and advancing our mission to promote resilient ecosystems and sustainable food systems.

Keywords: pollinator protection,honeybee health,veterinary product,transgenerational immunity,vaccine,deformed wing virus,beekeepers,sustainable agriculture,food security,biodiversity,one health
A Researchers' Night in The Mediterranean - Connecting Minds Through Research, Knowledge, and Culture (ERN-ApuliaMED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Italy,Spain,Türkiye,Albania
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-04-01
End date: 2026-01-31
Duration (months): 22.0
Total project cost (EUR): 209000.0
EU funding (EUR): 209000.0
Participants: 13
Project status: SIGNED

ERN-Apulia+MED targets to bring Citizens cERN-Apulia+ targets to bring Apulian Citizens closer to Researchers and viceversa and further extend the initiatives outside the region in the Mediterranean Area and extra-EU countries (at no cost), involving major public universities and Public and Private Research Institutions and representative schools. The large capacity of beneficiaries was already demonstrated in the past EU-funded projects for 2018- 2021 Nights and the continuation of activities in the unfunded 2022-2023 Nights. Here the initiatives for Citizens involvement will be further scaled up. Main objectives are: - to implement pre-events, the 2024 and 2025 ERNs and some post-events, with particular attention to students, industrial and professional organizations, municipalities and public administrations, already actively involved in the past editions; - to increase public awareness and recognition of the importance and impact of research in daily life, with specific examples from ICT to health and life sciences, from elementary particle to cultural heritage, etc; - to stimulate curiosity and interest and explain the fascinating world and the opportunities in research, especially to the youngest as a mean to encourage them to embark scientific careers; - to establish a tight connection among population/institutions and researchers to continue during the year; - to prepare and publicize dissemination materials along with scientific games and site visits (including laboratories and sites of cultural interest) to be available during the whole year for the general public; - to explain the spirit and opportunities of the European Research Area, the Marie Skłodowska-Curie actions and the principles of “The European Charter for Researchers”; to reach a number of Facebook Impressions >1.5M and Reach >400k, Youtube Views > 30k and watch time > 1000h, followers close to 200k, participants > 100k (among all the various initiatives) and a participants to the ERN > 50k.

Keywords: european researchers night,research dissemination,outreach,public awareness
Revealing the ancient plant ethylene biosynthesis and ACC signaling pathway (ETHYLUTION)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1999370.0
EU funding (EUR): 1999370.0
Participants: 1
Project status: SIGNED

When ancestral plants colonized the land 450 million years ago, they needed to adapt to harsh environmental conditions when giving up their aquatic lifestyle. I hypothesize that during this water-to-land transition, the volatile plant hormone ethylene became an important growth regulator to face terrestrial stressors. In fact, modern-day crops use ethylene to regulate stress responses, and perhaps ethylene served this role in pioneering land plants to cope with the harsh conditions coinciding with this habitat transition. During my postdoc, I showed that ethylene signaling was functionally assembled in ancestral Charophyte green algae, prior to land colonization. Now I question why and how early land plants produced ethylene. While seed plants make ethylene using ACC as precursor, non-seed plants follow a different, yet unknown ethylene biosynthesis pathway, which I want to reveal using the liverwort Marchantia polymorpha, a model species representing early life on earth. I also question why non-seed plants make ACC, but not use it for ethylene synthesis. Recent studies revealed that ACC itself can act as a signaling molecule, independent from ethylene, by an unknown signaling pathway to regulate plant development. I also postulate that both the alternative ethylene biosynthesis and ACC signaling pathway might have an origin in ancient algae, prior to land colonization, and might be conserved in seed plants, possibly exerting important functions yet to be uncovered. Using functional genetics in representative species of algae and crops, ETHYLUTION will unravel the importance and role of ACC and ethylene that allowed plants to thrive on earth, perhaps one of the most impactful events in the evolutionary history of plants.

Keywords: ethylene,1 aminocyclopropane 1 carboxylic acid,plant hormones,evolution,marchantia polymorpha