Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Three-Dimensional Nonlinear Chiral Plasmonic Metamaterials (3DNCPM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-03-01
End date: 2017-02-28
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The proposed project aims at a comprehensive understanding of the processes underlying the nonlinear optical responses of three-dimensional chiral plasmonic metamaterials (3DNCPM). Electromagnetic fields that interact with chiral plasmonic nanostructures result in strong chiroptical effects. Because their optical response is proportional to multiple powers of the enhanced near-field intensity, chiral metal nanostructures also constitute excellent candidates for nonlinear optical materials with new or improved properties. Utilizing advanced nanofabrication technologies, we are able to create complex three-dimensional metallic nanostructures and tailor their spectral response at will depending on the material properties, the nanostructure geometry, and its surrounding. The ability to concentrate light in sub-wavelength dimensions and to locally enhance the strength of the electromagnetic field in a tailored fashion will give us a full understanding of the physics behind the nonlinear optical mechanisms of plasmonics and chirality. Using sophisticated metamaterial designs, we aim at enhancing the nonlinear chiroptical effects and we believe that our work will provide a framework for exploiting the benefits of chiral nonlinear metasurfaces for novel applications, such as plasmonically enhanced mid-IR and THz generation, as well as nonlinear plasmonic sensing.

Keywords: plasmonics,metamaterials,nonlinear lithography
Complex Dynamics and Strange Attractors through Non-Autonomous Bifurcations (CDSANAB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-03-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This project aims at substantial contributions to the bifurcation theory of non-autonomous dynamical systems. The main research efforts will focus on an analytical investigation of the principles behind the creation of complex dynamical behaviour and strange attractors in the most common kinds of non-autonomous bifurcations: saddle-node and Hopf bifurcations. The project further aims at an interdisciplinary application of the analytical findings to the problem of the predictability of ice ages. The research on non-autonomous saddle-node bifurcations will extend the results of the applicant's PhD. Here, the main strategy is to apply powerful multiscale analysis techniques. Further, it is aimed at providing easily applicable tools for researchers in the life sciences to reliably track complex behaviour near saddle-node bifurcations. The research on the non-autonomous Hopf bifurcation will focus on the creation of chaos. In deterministically driven systems, the analysis will again be based on multiscale analysis techniques. In randomly driven systems, it is aimed at a profound extension of the work by the supervisor and his collaborators on shear-induced chaos. The host institution is not only a leading centre in bifurcation theory and non-autonomous dynamics but also the coordinating institution of the Marie Skłodowska-Curie Innovative Training Network (ITN) CRITICS which addresses critical transitions in complex systems. The interdisciplinary part of the project will be dealt with in collaboration with a partner of this ITN: the Theoretical Climate and Palaeoclimate Dynamics group at the Université catholique de Louvain. The Horizon 2020 key challenges include topics such as food security or climate action. Appropriate measures addressing related issues need to rely on a good understanding of complex systems which are non-autonomous by nature. Thus, profound insights into non-autonomous systems and bifurcations of such systems are of an immense European interest.

Keywords: strange attractors,non autonomous dynamics,bifurcation theory and its applications,chaos
Production and Testing of humAn-derived Neurons and brain organoids: advanced model probing in neurodevelopmental disorders (ProTeAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-07
End date: 2020-05-06
Duration (months): 24.0
Total project cost (EUR): 148635.6
EU funding (EUR): 148635.6
Participants: 1
Project status: CLOSED

Autism and associated neurodevelopmental disorders are chronic conditions that afflict 1 in 68 children and produce great costs to society. Lack of realistic models has hindered progression in our understanding of these disorders since core pathogenic defects may only arise in the context of complex human neuronal structures. Two recent breakthroughs have now enabled the development of improved models: the identification of stem cells in adult tissue; and the development of human organoids in vitro that allow the study of complex human neuronal networks. The ProTeAN projects aims to combine Neurobiological and Biotechnology research (key field in Horizon 2020), to: i) establish a dental stem cell biobank from autism patients and controls; ii) develop dental cell-derived brain organoids to explore neurobiological properties; iii) perform single-cell sequencing during the organoid generation process; iv) create proof-of-concept applications of brain organoids as a biomedical platform to test drugs. When developed, this platform will dampen the need for animal studies, reduce and contain the costs associated with drug developments and provide personalized medical testing devices with a minimally invasive strategy. This project counts on the applicant’s expertise on stem cells, differentiation and bioinformatics, and on the expertise of supervisor João Peça and collaboration from Lino Ferreira (expert in bioengineering) and Guoping Feng (expert in autism research) to assure the success of all tasks. The applicant has established a career development plan and will partake in outreach activities to engage different target audiences in issues pertaining to this project. An EF-RI fellowship will facilitate the responsibility of spreading the researcher's knowledge to European partners, improve leadership and mature research goals while contributing to the evolution of science and improvement of society.

Keywords: autism,dental stem cells,organoids,circuits,electrophysiology,personalised medicine
Seamless mixing of virtual & real-world objects in VR & AR (LightField)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Monocular depth perception (eye accommodation) is missing in all today's virtual (VR) & augmented reality (AR) headsets & goggles. At best they provide an illusion of the 3rd dimension (depth, in this case) through stereoscopic vision using binocular cues only. Current devices use a flat display whereby each eye is forced to focus on a flat image. This results in so called vergence-accommodation visual conflict which causes an unpleasant eye strain & reduces the immersive effect of VR/AR. Research from the Samsung Mobile VR team has shown that most people with unimpaired vision start experiencing discomfort after using a VR headset longer than 20 mins. While this visual conflict is already a problem in VR applications, it is a major obstacle for AR applications, where an eye needs to focus on both the real & virtual objects at the same time. We have developed a novel light-field display technology for VR/MR that creates genuine 3D virtual images & mixes them naturally with the real world ones. Our display technology correctly processes all information about the intensity & direction of light rays from the virtual images (by creating a light field), realistically blurs/unblurs virtual objects depending on their distance from the viewer. Our patented technology works without eye tracking & has the potential to be scaled down to miniature form factors, effectively enabling VR/AR headsets the size of regular reading glasses. We have started early sales of our technology closing a €50,000 deal with Samsung Mobile (KR). In 2018 we have raised €750,000 from the Swiss ICT Investor Club, Atmosclear Investments & prominent business angels. We are currently working on bringing to the market our first product—a light-field projector for VR headsets. We are aiming to reach €15m in revenues by 2023 & 50+ FTEs.

Keywords: smart glasses,light field,reality
Characterize corpus callosum-mediated local and global inhibitory effects with novel MRI-compatible photonic crystal fiber-based multifunction probe and wireless amplified NMR detector in rat brain (CCMuPWA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2023-06-30
Duration (months): 30.0
Total project cost (EUR): 205352.64
EU funding (EUR): 205352.64
Participants: 2
Project status: SIGNED

The structural anomalies of corpus callosum (CC) in patients are found highly-correlated with a wide range of disorders, e.g., epilepsy, autism, schizophrenia and mental retardation. However, it remains unclear about the causal contributions of CC-mediated functional changes to these disorders and exactly how the changes influence the local cortical circuitry. Lately, we have successfully combined fMRI with fiber optic mediated calcium recordings and optogenetics, i.e., multi-modal fMRI, to study the balance of excitation/inhibition in the barrel cortex in rats by pairing optogenetic corpus callosum activation with ascending thalamocortical activation. However, it remains challenging to maintain high sensitivity to the brain dynamic signal and better decipher CC-mediated unique cellular (neuron/astrocyte) or layer-specific contributions to the local cortical or global whole-brain fMRI signals. Therefore, the goal of this proposal is to optimize the multi-modal fMRI platform and to characterize the brain activity upon optogenetic callosal activation with higher spatial/temporal resolution using two cutting edge technologies, wireless amplified nuclear MR detector (WAND) and photonic crystal fiber (PCF). Previously, we have implanted a wireless RF coil into the rat body to achieve a high signal-to-noise ratio and spatial resolution for in vivo kidney imaging. The modified WAND will be incorporated into the multi-modal fMRI platform to achieve brain dynamic signal with enhanced sensitivity from the barrel cortex. Next, we will merge it with a novel PCF-based probe integrated calcium recording, optogenetic manipulation and fluid injection function. This proposal will merge the neuronal and astrocytic dynamic signals to the functional mapping, solve the challenges for CC study at multiple scales in the brain, enable novel applications of the multi-modal fMRI platform to better decipher the neuroglial interactions in normal and diseased animal models for future studies.

Keywords: excitation,inhibition balance,barrel cortex,corpus callosum,neuron,astrocyte,fmri,optogenetics,calcium recording,wireless amplified nmr detector,photonic crystal fiber,mri compatible light path
New generation of nanoporous organic and hybrid aerogels for industrial applications: from the lab to pilot scale production (NanoHybrids)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Efficient and sustainable synthesis and manufacturing of nanomaterials, components and systems
Action type: Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Germany,Türkiye,Greece,Greece,Russian Federation,Sweden,France,United Kingdom
Call: Manufacturing and control of nanoporous materials (H2020-NMP-PILOTS-2015, 2015)
Start date: 2015-11-01
End date: 2019-04-30
Duration (months): 42.0
Total project cost (EUR): 4354905.75
EU funding (EUR): 3678305.25
Participants: 15
Project status: CLOSED

The main objective of the project is the development of the pilot scale production system of the new generation of nanoporous organic and hybrid aerogels with multiple functions for application in gas and humidity adsorption, personal care and food. Thereby the fast manufacturing in form of spherical particles will be in focus in order to reduce the process time and to decrease the overall process costs. Thereby the purpose is to insure the high porosity and internal pore size distribution of the particles in order to provide the high surface area, pore volume and defined pore size needed for good adsorption capability. The production of organic aerogel particles in sufficient amounts will firstly enable the possibility to build prototypes for the applications in gas and humidity adsorption and food and to perform the corresponding tests. Based on the results of the test the properties of aerogels will be fine-tuned for the corresponding real applications in industrial environments. By this means it is intended to increase the technology readiness level of organic aerogels production from TLR 4 to TLR 6 by the end of the project.

Keywords: organic aerogels,pilot scale production
Patient empowered Diabetes care in ambulatory settings (PaDiCare)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Denmark,Denmark
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-11-01
End date: 2017-03-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Atonomics and InTeleCare4U’s joint vision is to bring Trace to market, a Point-of-Care (POC) blood biomarker monitoring system for Diabetes Mellitus (DM) that syncs highly accurate and precise lab results to hospital’s electronic patient record (EPR). Trace has such a simplified user experience that patients can perform their own blood analysis without nurses performing the blood draw or lab staff analysing the sample. Trace analysis require just a drop of blood obtained through finger-pricking, the same procedure that diabetic patients use for daily glucose monitoring. Analysis runs automatically in a very short time (5-7 min per biomarker) and the results are then synced to doctors’ PC / tablet through ITC4U’s data sync services – based on the open source OpenTele platform. Trace system combines the following three key elements for effective and resource-efficient monitoring: - Trace device, an easy to use, lab-grade device to measure HbA1c and lipid panel biomarkers for DM monitoring; - Trace tablet app, a step-guided application that helps patients use the Trace device, and collects the results from Trace; - ITC4U’s secure sync infrastructure that transmits patient data collected in app directly to the doctor’s tablet or PC. With the growing share of DM patients, the availability of clinicians will become a bottleneck for proper care. Patient involvement in these analyses is the best option for sustainability of care. Trace addresses this market. The short assay run time means that patients can perform blood analysis just before their regular appointments, already at the ambulatory unit, saving hours in waiting rooms and trips to labs. Hospitals benefit from faster patient turnover, providing care to more patients with the same resources (i.e. higher efficiency and higher care accessibility). Over time, Trace will be able to expand biomarker monitoring to other chronic diseases, through the development and market introduction of further assays for Trace.

Keywords: chronic disease,diabetes mellitus,remote monitoring,blood analysis,biomarker control
HgCdte APD Optimization for Lidar Detection Of greeNhouse gases (HOLDON)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Switzerland,France,France,France,France
Call: Competitiveness in Earth observation mission technologies (H2020-COMPET-2017, 2017)
Start date: 2018-01-01
End date: 2022-03-31
Duration (months): 51.0
Total project cost (EUR): 2508571.25
EU funding (EUR): 2508571.25
Participants: 9
Project status: CLOSED

Lidar remote sensing of the earth’s atmosphere is one of the main challenges in coping with the effects and causes of global warming caused by the emission of greenhouse gases. The present operating Lidar missions are all implanted on large satellite platforms due to the size of the telescope and high energy laser modules required to ensure a sufficient collection of light to extract the signal from the detector noise. The principal objective of HOLDON project is to develop a new detection chain which will improve the performance of the Lidars on large platforms and/or reduce the Lidar payload to be integrated in the future micro and mini-satellites. The performance increase is obtained by the optimization of HgCdTe avalanche photodiodes that will be hybridized to a CMOS Readout Circuit providing two operation modes and designed to meet the most demanding requirements for Lidar applications in terms of sensitivity, dynamic range and temporal resolution. To achieve these goals, a team of 7 partners, leaders in the different fields related to Lidar missions, will collaborate (4 represented EU member states). To this end, three ambitious objectives are defined: • Design and built a cutting-edge photon noise limited Lidar detection chain • Validate adequation between detection chain key performances and future space mission requirements • Demonstrate the improvement achieved with the cutting-edge detection chain for greenhouse gases detection COMPET-2-2017 aims at supporting project developing new technologies, systems and sub-systems for Earth observation in a relevant environment. According to this call, HOLDON project addresses i) “Detector technolog y and complete detection chain enhancement in the domains of CMOS and Infrared for Earth observations”, ii) “Sensors and mission concepts delivering high accuracy parameters for emission measurements.

Keywords: lidar detector,dial,cmos,roic,avalanche photodiode,ipda,greenhouse gases,ch4 and co2 measurement,global warming,earth observation,technology for space,detector,high dynamic range
From Supramolecular Chemistry to Organocatalysis: Fundamental Studies on the Use of Little-Explored Non-Covalent Interactions in Organic Synthesis (XBCBCAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-04-30
Duration (months): 60.0
Total project cost (EUR): 1497916.26
EU funding (EUR): 1497916.26
Participants: 1
Project status: CLOSED

Hydrogen-bonds have found widespread use in various fields of chemistry, including supramolecular chemistry, organic chemistry, and more lately organocatalysis. Although a multitude of structurally different hydrogen-bond donors has been developed, their mode of action is in all cases necessarily based on the same interacting atom, hydrogen. In this proposal, we aim to develop first applications for two, previously very little explored non-covalent interactions that are based on electrophilic halogen or chalcogen substituents (“halogen-bonds” and “chalcogen bonds”). The first objective is to open the way for the use of chiral multidentate halogen-bond donors (i.e., halogen-based Lewis acids) for enantiodiscrimination. After the synthesis of suitable candidate compounds, we will apply them in the following research areas: a) the resolution of racemic mixtures by co-crystallization with chiral halogen-bond donors, and b) the use of these Lewis acids in enantioselective organocatalysis. Within the second objective, we will strive to establish first-of-its-kind applications of chalcogen-based Lewis acids in organic synthesis and organocatalysis. In contrast to halogen-bonds, chalcogen-bonds feature two substituents on the interacting atom as well as two electrophilic axes. In the first phase of this aim, we will synthesize neutral and cationic, mono- and bidentate candidate compounds and determine their association constants with a variety of Lewis bases. Based on this date, we subsequently seek to use these novel Lewis acids as activators or catalysts in organic transformations. We anticipate that the realization of these applications, all of which are unprecedented, will be a crucial first step towards establishing further non-covalent interactions as useful tools in chiral recognition and chemical synthesis. In the long-term, we foresee these little-explored interactions becoming powerful complements to the ubiquitous hydrogen-bonds.

Keywords: non covalent interactions,halogen bonding