Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecularly Imprinted Photoactive Microswimmers for PFAS Capture and Detection (PhotoSERS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-11-01
End date: 2027-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, are persistent organic pollutants of global environmental concern with serious health risks. Their extensive industrial use and toxic effects have led to the implementation of stringent regulations worldwide, highlighting the urgent need for more efficient and sensitive PFAS detection technologies. Current detection methods are often inefficient, time-consuming, and lack the sensitivity required for trace-level analysis and accurate identification. This project, PhotoSERS, aims to develop an innovative technology based on light-driven microswimmers capable of both capturing and detecting PFAS in water. These microscale devices combine active motion with selective molecular recognition. By integrating advanced spectroscopic detection and portable instrumentation, the system aims to enable real-time, sensitive, and reproducible monitoring of these contaminants. Collaboration with industrial partners will ensure the industrial relevance of our technology by providing critical feedback on performance requirements, and supporting validation in real operational settings, ultimately accelerating its path to commercialization. Therefore, this innovative portable microswimmer-based device could contribute significantly to water monitoring technologies and environmental protection efforts by providing an efficient, field-deployable solution for PFAS capture and detection.
Epithelial Memory to Candida albicans during commensalism and infection (EPIMemory)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

In this research project I seek to discover the mechanisms underlying oral epithelial cell (OEC) memory and its importance to control Candida albicans infections and commensalism. C. albicans is part of the healthy microbiota, but it is also the most clinically relevant fungus. Fine tuning of mucosal immunity enables homeostasis and regulates commensal-to-pathogen transition of C. albicans. Innate immune cells, such as macrophages, can develop long-term responses during systemic infections, enabling them to clear invading microbes more efficiently. This so-called process of “innate immune memory” can be targeted in order to improve patient outcomes. However, at the oral mucosa, where immune cells are more scarce, OECs are essential for controlling fungal growth and orchestrating complex immune responses. Whilst OEC-C. albicans interactions have been well analysed during acute infections, no study up to date has addressed epithelial memory or its impact on fighting fungal infections and regulating Candida commensalism. The aim of this project is to understand the molecular and cellular mechanisms driving epithelial memory in response to C. albicans. In preliminary in vitro studies, I have shown that epithelial memory protects OECs from C. albicans and therefore, I hypothesised that this phenomenon control fungal growth during pathogenesis and homeostasis. I will use advanced models of host-microbe interactions to confirm the importance of epithelial memory for clearing infections and whether it promotes fungal commensalism by regulating microbial growth. I will decipher the underlying molecular mechanisms by analysing gene expression and metabolic profiles of memory cells, and identify potential targets that promote homeostasis at the oral mucosa. This project will yield novel insights into mucosal fungal immunology, essential knowledge to further comprehend how out body interacts with the microbiota and to identify targets to advance in the treatment of candidiasis.

Keywords: epithelial memory,innate immune memory,epithelial cells,fungal immunology,immunometabolism,host microbe interactions,microbial metabolism
Breakthrough Brain Stimulation Device for Epilepsy (BFORE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 3565480.0
EU funding (EUR): 2495836.0
Participants: 1
Project status: CLOSED

EASEE® stands for epicranial application of stimulation electrodes in epilepsy. It is the first minimally invasive device for focal cortical stimulation. Based on the Laplace electrode (central electrode surrounded by a ring electrode), EASEE® features 4 distinct electrodes replacing the outer ring, connected to 4 independent current sources to account for impedance and anatomical variances in the human skull. Still, the characteristic quadrupolar local electric field with high penetration depth is maintained. The stimulation pattern is one of a kind. EASEE® is equipped for high frequency, DC-like, and low-frequency stimulation, depending on the condition to be treated. In epilepsy, intermittent high-frequency stimulation bursts throughout the day are combined with a 20min DC-like stimulation session. This first is meant to terminate upcoming seizures, the second to initiate neuromodulatory processes to down-regulate the overexcitability of the epileptic brain area.

Keywords: minimally invasive,neurostimulation
Spectral Geometry of Higher Categories (GeoCats)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The overarching goal of this project is to reveal and systematically study the geometry of important categories in homotopy theory, algebraic geometry, and representation theory. To this end, we will introduce and develop the framework of higher Zariski geometry in which commutative rings are replaced by ring-like categories as the fundamental objects. The resulting theory simultaneously generalizes modern algebraic geometry, derived algebraic geometry as studied by Lurie and Toën--Vezzosi, as well as Balmer's tensor triangular geometry, while introducing entirely new global objects and methods. In particular, it provides a canonical spectral decomposition of a large class of higher categories over their Balmer spectrum, which is then used to produce powerful new tools to tackle some of the most important conjectures in their respective fields: Firstly, we will construct a higher analogue of the étale topology and étale homotopy types for such categories, giving rise to refined computational tools via descent. This machinery will be applied to modular representation theory to give a complete description of the group of endotrivial modules for any finite group and any field, extending the celebrated work of Carlson--Thévenaz and completing a program that began about 50 years ago. Secondly, we will introduce a categorical analogue of the Beilinson--Parshin adèles, in particular bringing to bear techniques from the point-set topology of spectral spaces. Applications include significant progress on Greenlees' conjecture on algebraic models for G-equivariant cohomology for a general compact Lie group G, which has remained open for more than 20 years. Thirdly, building on our earlier work on higher ultraproducts, we will study compactifications of categories and plan to combine these with recent advances in arithmetic geometry to make progress on the rational part of Hopkins' chromatic splitting conjecture, one of the most important open problems in homotopy theory.

Keywords: tensor triangular geometry,balmer spectrum,higher algebra,derived algebraic geometry,picard spaces,chromatic splitting conjecture,rational g spectra
Secure AI and Digital Twin Empowered Smart Internet-of-Energy (SAILING)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,Spain,Poland,Denmark,Austria,Lithuania,Norway
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-01-01
End date: 2029-12-31
Duration (months): 48.0
Total project cost (EUR): 4024633.89
EU funding (EUR): 3642641.28
Participants: 11
Project status: SIGNED

The Internet-of-Energy (IoE) is a revolutionary paradigm towards achieving the EU’s zero-carbon goal through enabling intelligent and automated energy management across the entire lifecycle of energy planning, storage, distribution, and maintenance. Operating in highly complex environments characterised by intermittent and volatile renewable energy generation, dynamic energy demands, large-scale distributed energy integration, and stringent resilience and security requirements, IoE faces fundamental challenges in constructing accurate and real-time digital representation, securing Artificial Intelligence (AI) solutions, optimising energy management, and diagnosing device faults and failures. To address these challenges, SAILING aims to establish a multidisciplinary network of world-leading academic and industrial partners to create a ground-breaking smart system for energy management and fault diagnosis powered by innovative digital twin and secure AI technologies. Specifically, SAILING will pioneer transformative research and innovations, including: 1) AI-driven high-fidelity digital twin for IoE digital representation, 2) Secure and reliable AI for IoE empowered by Blockchain and adversarial machine learning, 3) Intelligent and scalable predictive energy management and optimisation, and 4) Deep learning-based rapid fault detection and accurate failure prediction. SAILING will train 12 Early-Stage Researchers across sectors and disciplines in the novel concepts and methodologies of smart IoE, equip them with sought-after professional and transferable skills, foster broader perspectives, and cultivate them to become future leaders in IoE. Through cutting-edge research and multidisciplinary cross-sectoral collaborations, SAILING will drive scientific breakthroughs with innovative digital twin and secure AI technologies for realising reliable, resilient, and energy-efficient smart IoE, and revolutionising the energy sector for a more sustainable and cleaner future.

Keywords: internet of energy,secure ai,digital twin,edge computing,smart energy management
Turku Intersectoral Excellence Scheme (TIES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Finland
Call: MSCA COFUND 2021 (HORIZON-MSCA-2021-COFUND-01, 2021)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 1146240.0
EU funding (EUR): 1146240.0
Participants: 2
Project status: SIGNED

Turku Intersectoral Excellence Scheme (TIES) is an innovative fellowship programme that seeks to advance the state-of-the-art for postdoctoral research excellence. It is based within Turku Institute for Advanced Studies (TIAS) at the University of Turku (Finland) and is supported by Turku Science Park. TIAS has a record for producing world-class research and developing its fellows for research leadership roles. TIES offers: • Scientific excellence: TIES integrates intersectoral perspectives and methods into TIAS’s interdisciplinary Institute for Advanced Studies model on a formal basis. This expands the horizons of academic research, enabling it to envision original solutions able to address complex issues that affect society as a whole. • Career development: TIES offers a new range of options for non-tenured researchers, enabling them to move freely between sectors, acquire unique skills and experiences, increase their career choices and develop as intersectoral thought leaders. • Innovation: TIES seeks to build a sustainable infrastructure for innovation by 1. enabling knowledge, technology and researchers to circulate freely at regional, national and international levels; 2. forging deep relations of trust between sectors, connecting intellectual excellence with the practical know-how and infrastructure needed to realise new concepts. TIAS proposes to recruit 4 TIES fellows in 2022 and 2023 (8 positions in total) through an open, international, competitive, merit-based selection process dependent on external peer-review, in line with the European Charter and Code. These will be full members of TIAS, with excellent working conditions. During their 36-month fellowships, they will be required to practice international and intersectoral mobility, conduct research in a non-academic sector, undertake research secondments with a non-academic host organisation, and develop an individual development programme with mentors and supervisors from inside and outside academia.

Keywords: institute for advanced studies transdisciplinarity non academic impact knowledge exchange mentorship leadership development training autonomy bottom up intersectoral career development
Novel analytic methods for precision Higgs boson physics (HINOVA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 292118.88
EU funding (EUR): 292118.88
Participants: 1
Project status: SIGNED

One of the current main goals in particle physics is the precise determination of Higgs boson properties, which simultaneously serves as a probe to new physics beyond the Standard Model (SM). The SM has been highly successful in describing the fundamental interactions of nature. However, the nature of the Higgs boson is not completely determined, and unsolved problems such as the origin of dark matter persist. These challenges call for precise studies of Higgs boson properties and searches for new physics, which are being conducted at the Large Hadron Collider (LHC). In this context, precise comparisons between theoretical predictions and experimental measurements in collider observables are crucial, particularly in boosted Higgs boson production associated with a vector boson or jet. These comparisons require advanced multi-loop calculations for higher-order quantum corrections in perturbative Quantum Field Theory. HINOVA will develop novel analytic techniques for multi-loop calculations, and aim to provide cutting-edge predictions for gluon-fusion Higgs boson production associated with a Z boson or jet at the LHC in the boosted region. Its primary goal is to analytically compute the missing next-to-leading order quantum electroweak corrections for these predictions. The main challenge lies in the calculation of two-loop four-point Feynman integrals involving top quarks, Higgs and gauge bosons. This challenge will be addressed using AsyInt, a novel analytic tool independently developed by the researcher. Its secondary goal is to establish a new method in AsyInt to analytically compute three-loop four-point Feynman integrals involving top quarks at high energies, which appear in next-to-next-to-leading order quantum chromodynamic (QCD) corrections for these predictions. HINOVA will deliver new results and methods that are instrumental for the most precise studies of Higgs boson properties and for new physics searches at the LHC and future high-energy colliders.

Keywords: higgs boson physics,electroweak physics,collider physics,lhc,perturbative quantum field theory,multi loop feynman integrals,scattering amplitudes,automation and tools
Beta-cell recovery to counter diabetes (DiogenX)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 5673000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Globally 8,75M people with T1D rely only on insulin administration to manage the symptoms of their disease. The treatment is complex since it requires injecting insulin (2-4 times/day) and adhering to a restrictive lifestyle (e.g., following a strict diet) reducing patient QoL. Even with insulin, less than 20% of patients achieve their target glucose level, which eventually leads to vascular complications (e.g., stroke, renal disease) reducing life expectancy by 10-15 years. DiogenX aims to withdraw insulin dependency and cure T1D by regenerating pancreatic beta-cell to allow autonomous insulin release in response to blood glucose levels increases. We expect to out-license our drug to a pharma company, some of them have already manifested their interest and invested in the capital of DiogenX. This may materialize as soon as clinical proof of principle is demonstrated in humans, which will be reached in 2026 with the proceeds from Series A to be raised in 2023, which is 80% secured.

Keywords: disease modifying,regenerative medicine,autonomous insulin production,restoration of pancreatic beta cells,biomarkers,personalized diagnostic,diabetes cure,rspo1 protein,diabetes type 1
Understanding the molecular basis of protein folding disorders and protein quality control in muscle (MUSCLE-QC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2498824.0
EU funding (EUR): 2498824.0
Participants: 1
Project status: SIGNED

Mutations in certain proteins can cause their misfolding and aggregation, posing a potential threat to the health of an organism. Protein aggregation is counteracted by protein quality control (PQC) mechanisms that reduce the amounts of damaged molecules. As we age, however, the crucial surveillance mechanisms weaken and become less effective, leading to protein misfolding diseases. The most well-known protein disorders, or proteinopathies – Alzheimer's, Huntington's, and Parkinson's diseases – are characterized by the formation of toxic protein aggregates, known as amyloids. Current research focuses on such amyloid diseases, however, there seem to be many other, hidden protein disorders. In principle, every mutation in a protein can affect its folding and stability and may become pathological only when PQC mechanisms are compromised. To better understand this kind of proteinopathy, we will generate novel PQC tools and study muscle protein disorders in the nematode Caenorhabditis elegans. We will design dual-colour fluorescent protein reporters to monitor the misfolding and aggregation of disease-linked myosin variants, our model proteins. The ‘MyoState’ library, comprising hundreds of mutants with a broad range of folding defects, will allow us to study the pathological impact of individual myopathy mutations and investigate cellular rescue mechanisms. In C. elegans, myosin disease mutations cause characteristic defects in motility and muscle structure, which can be rescued by dietary restriction. This animal model thus provides us with a unique opportunity to perform genome-wide screens that will define the PQC network in muscle cells. By performing structural and functional analyses of key factors in this network, we aim to reveal the fundamental mechanisms of myosin quality control and its regulation. Our ultimate goal is to understand how the misfolding of functional proteins, whether due to mutation or age, impairs cell function.

Keywords: protein quality control,protein misfolding disease,proteostasis network,proteinopathy model in c elegans