Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
NUCLEUS - New Understanding of Communication, Learning and Engagement in Universities and Scientific Institutions (NUCLEUS)

Framework: Horizon 2020 — Science with and for Society
Programme: Integrate society in science and innovation issues, policies and activities in order to integrate citizens' interests and values and to increase the quality, relevance, social acceptability and sustainability of research and innovation outcomes in various fields of activity from social innovation to areas such as biotechnology and nanotechnology
Action type: Coordination and support actions
Countries involved: Austria,Germany,Germany,Ireland,Germany,South Africa,Germany,Italy,Germany,Malta,Greece,China,Serbia,Georgia,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Supporting structural change in research organisations to promote Responsible Research and Innovation (H2020-ISSI-2014-1, 2014)
Start date: 2015-09-01
End date: 2019-08-31
Duration (months): 48.0
Total project cost (EUR): 3993632.5
EU funding (EUR): 3993632.5
Participants: 25
Project status: CLOSED

NUCLEUS develops, supports and implements inclusive and sustainable approaches to Responsible Research and Innovation within the governance and culture of research organisations in Europe. A major goal of the transdisciplinary project will be to stimulate research and innovation which continuously reflects and responds to societal needs. In order to achieve a multifaceted and cross-cultural New Understanding of Communication, Learning and Engagement in Universities and Scientific Institutions, 26 renowned institutions from 15 countries, among them leading representatives of 14 universities, will collaboratively identify, develop, implement and support inclusive and sustainable approaches to RRI. For a mutual learning and exchange process, the project will reach out beyond the European Research Area by including renowned scientific institutions in China, Russia and South Africa. Within a 4-year timeframe NUCLEUS will systematically uncover and analyse structural and cultural obstacles to RRI in scientific institutions. The partners will collaboratively develop innovative approaches to overcome these barriers. The project is expected to lead to an applicable ‘RRI DNA’, providing practical guidelines for higher education institutions and funding agencies across Europe and beyond. This ‘DNA’ will form the basis for the ‘NUCLEUS Living Network’, an alliance to ensure sustainability of the approach beyond the project timeline. By offering new academic insights and practical recommendations derived from 30 ‘RRI test beds’, NUCLEUS will contribute to the debate on science policies both on a national and European level, including the future design of HORIZON 2020 and the European Research Area (ERA).

Keywords: public engagement,governance,transdisciplinary research,societal engagement,science with and for society
Urban modelling in higher dimensions: embedding generalisation of 3D data in a 4D model (UMnD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2022-11-30
Duration (months): 75.0
Total project cost (EUR): 1498148.0
EU funding (EUR): 1498148.0
Participants: 1
Project status: CLOSED

Geographic data about urban objects (buildings, roads) is needed to monitor and control processes within modern urban areas (noise, flooding, energy demand-supply). As these processes occur in 3D, urban applications require 3D data and each application requires its own specific semantic and geometric Level of Detail (LoD) of the 3D data. The scientific challenge of this project is that it requires enormous efforts to collect and transform 3D data to make it suitable for a specific application. Urban applications are therefore forced to work mainly in 2D. This reduction causes the loss of important information. A solution is needed to support the reuse of once collected 3D data in multiple applications. I will develop a fundamental solution for providing 3D data at application specific LoDs to solve the current problem of independently acquired and stored LoDs of a 3D urban model. To enforce consistency across dimensions, the LoDs will be modelled as an extra dimension to the 3D spatial dimensions in an integrated 3D+LoD (4D) model. I will use an innovative method that goes far beyond the state-of-the-art by introducing higher dimensional (nD) mathematical models to the well-established domain of cartographic generalisation in 2D. Furthermore, I will study 3D generalisation solutions to derive coarse from fine data and embed these in the 4D model. “Slicing” operations will be developed that reduce the dimensions of the 4D data to generate error-free 3D data at application specific LoDs. LoD is strongly related to map scale, a well-known concept in GIS. However, modelling it as an extra dimension of geographic data is new. In addition, the intermediate results have the potential to advance the field of geo-information technology, such as the ground-breaking extension of the 2D cartographic generalisation domain to 3D. If successful, the 4D approach opens a new horizon for modelling parametrisable aspects of urban environments, which may establish a new research line.
A cell separation microfabricated platform for cell migration and invasion assays (TOPOCELL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France,France
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

Cell migration is essential for tissue development, homeostasis, tumor progression, including the responses to wounds and inflammation. Cell interactions with their microenvironment affect many cellular functions such as spreading, migration and even differentiation. These interactions can be studied by incorporating micro- and nanotechnology-related tools. The design of substrates based on these technologies offers new possibilities to probe the cellular responses to changes in their physical environment. The investigations of the physical interactions of cells and their surrounding matrix can be carried out in well-defined and near physiological conditions. In tissues, cells encounter confined environments and narrow spaces that could favor or prevent migration. In the DURACELL ERC project, we are studying the impact of substrate stiffness on cell migration. We propose to develop and use microfabricated substrates to control substrate confinement and topography and thus analyze cellular responses. Such elastomeric substrates are designed that contain ordered micron-sized pillars allowing cells to transmigrate through versatile confined spaces. The development of accurate methods to study cellular transmigration is important to answer fundamental biological processes and for cell-based therapy and drug screening. The well-accepted methods for transmigration assays including Boyden chambers, microfluidic devices present important limitations including spatial and temporal resolutions, limited variability and control of porosity composition and geometry. To overcome these limitations, the goal of TRANSCELL is to develop in-plane micropillar substrates whose geometry can be easily tuned to control and analyze cell transmigration, cell sorting and ultimately genetic expression profiles. We anticipate that the versatility of this method will offer new opportunities for fundamental research in cell biology, but also in cell therapies and drug screening.

Keywords: mechanobiology,cell invasion,microfabrication,cell sorting,cancer
Predictive modelling of 3D genome topology during progressive stages of embryonic development (4DGenomeReg)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The mechanisms that regulate genome activation and gene expression occur within a complex three-dimensional (3D) architecture, that helps bring functional regulatory elements into spatial proximity. Although observed at individual loci, the general principles and dynamics of enhancer-promoter interactions remain very poorly understood. The proposed project will use chromosome conformation capture, Hi-C, to measure 3D chromatin interactions at a genome-wide scale across different stages of embryogenesis. The project will build on the Furlong lab’s recent findings in genome topology. First, it will look at changes in chromosome conformation during the entire developmental time-span to determine if the stability of interactions observed during the early stages holds true to the end of embryogenesis. It will also compare high-resolution interaction frequencies in two different cells types (mesodermal and neuronal) during different stages of development. The project will consider the entire spectrum of possible interactions, as opposed to a narrow set of enhancers, and thereby yield the first high-resolution view of the overall topology of the Drosophila genome as it develops and the general ‘search-space’ of developmental enhancers. Second, the results will identify constitutive and dynamic chromatin interactions, revealing the extent to which enhancer-promoter interactions change between cell types as they transition from a multipotent state to a terminally differentiated tissue. Third, these data will be used to make an integrative predictive model of chromatin loop formation, which should yield mechanistic insights into how chromatin contacts are formed and predict their dynamic or constitutive behaviour. Given that the general principles underlying genomic architecture are deeply conserved, the project should not only help to explain regulatory principles underlying Drosophila development, but also greatly enhance our understanding of general chromatin organization.

Keywords: gene regulation,dna regulatory elements,chromosome conformation,chromatin structure,3d genome topology,topological domains,long range interactions,chromatin loops,embryonic development,hi c
Nanoscale live-cell activity sensing using smart probes and imaging (NanoCellActivity)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2022-07-31
Duration (months): 66.0
Total project cost (EUR): 1368250.0
EU funding (EUR): 1368250.0
Participants: 1
Project status: CLOSED

Fluorescence microscopy is the tool of choice for live-cell imaging. Its usefulness has been further enhanced by the availability of genetically-encoded biosensors, which enable the visualisation of when and where a certain activity arises. In addition, the development of diffraction-unlimited imaging has dramatically improved the spatial resolution of fluorescence imaging. However, these techniques have had difficulty working with biosensors, largely limiting the information to the spatial location of the labels. This project seeks to develop diffraction-unlimited imaging of biosensors, creating activity maps with a diffraction-unlimited spatial resolution in living systems. I propose to meet this challenge using a two-pronged approach, focusing both on the development of labels and sensors as well as new imaging tools and strategies. Based on existing scaffolds, we will develop sensors that display strong photochromism, providing reversible fluorescence dynamics intrinsically suited to superresolution imaging. In tandem, we will develop imaging strategies that focus on robustness and work well in living systems, in exchange for a spatial resolution of a 50 to 70 nm and a temporal resolution of a few seconds or less. We will use these developments in the study of the nanoscale spatiotemporal regulation of G-protein-coupled receptor (GCPR) signalling in living systems. By extending sub-diffraction imaging to the molecular environment, this project will contribute new insights into long-standing research questions that directly involve the health and well-being of all of us, while also enabling exciting prospects for further research.
Coordinated Use of miniaturized Robotic equipment and advanced Sensors for search and rescue OpeRations (CURSOR)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Increase Europe's resilience to crises and disasters
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Austria,Ireland,Greece,Norway,Greece,France,France,France,United Kingdom,Japan,United Kingdom,United Kingdom,United Kingdom
Call: Technologies for first responders (H2020-SU-SEC-2018, 2018)
Start date: 2019-09-01
End date: 2023-02-28
Duration (months): 42.0
Total project cost (EUR): 7461361.48
EU funding (EUR): 6999822.5
Participants: 20
Project status: CLOSED

The CURSOR proposal aims at developing new and innovative ways of detecting victims under debris. This includes the coordinated use of miniaturized robotic equipment and advanced sensors for achieving significant improvements in search and rescue operations with respect to (a) the time used to detect trapped victims after a building structure has collapsed, and (b) an informed and accelerated decision making by first responders during rescue operations allowing for the deployment of expert personnel and, in particular for operations in hazardous environments, suitable equipment at prioritized locations. CURSOR is proposing a system consisting of several integrated technological components. It includes Unmanned Aerial Vehicles (UAVs) for command & control, 3D modelling and transportation of disposable miniaturized robots, that are equipped with advanced sensors for the sensitive detection of volatile chemical signatures of human beings. Information and data collected are transferred in real time to a handheld device operated by first responders at the disaster site.

Keywords: usar,search and rescue
The Cog in the Ratchet: Illuminating the Cognitive Mechanisms Generating Human Cumulative Culture (RATCHETCOG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-02-28
Duration (months): 66.0
Total project cost (EUR): 1780453.5
EU funding (EUR): 1780453.5
Participants: 1
Project status: CLOSED

In human populations, skills and knowledge accumulate over generations, giving rise to behaviours and technologies far more complex than any single individual could achieve alone. This ratchet-like property of human culture appears absent in nonhuman species, as socially transmitted behaviours in animal populations are generally no more complex than those that can be acquired by trial and error. Scientists from a wide range of disciplines have offered high-profile speculative theories about the underlying differences that might be responsible for this striking evolutionary discontinuity, but adequate empirical evidence is still lacking. In the RATCHETCOG project, Dr Caldwell and her team will, for the first time, implement a comprehensive systematic investigation into cumulative cultural evolution, using an experimental method that offers sufficient flexibility to generate valid comparisons across three critical research domains: species differences across the primate family tree; age differences over human development; and learning condition differences in groups of adult human participants. The methods devised for the project will make it possible to both measure and manipulate the complexity of the behaviours learned, thus offering a tool for analysing the extent of ratcheting under different conditions and across different populations. Each of the three research strands provides a vital source of evidence. Studies of nonhuman primates will reveal the limits on learning in these species, and studies with children will provide key opportunities to determine which cognitive abilities predict the development of capacities for cumulative culture. Finally, comparing different learning conditions in groups of adults is critical, as these experiments will allow clear causal conclusions regarding prerequisites and constraints, in relation to task complexity. The project will therefore fully expose the cognitive machinery responsible for the uniqueness of human culture.

Keywords: cumulative culture,imitation,learning,comparative cognition,developmental psychology,microsocieties,theory of mind
European Sustainable BIObased nanoMAterials Community (BIOMAC) (BIOMAC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Innovation actions
Countries involved: Italy,Spain,Italy,Spain,Spain,Italy,Germany,Germany,Spain,Spain,Germany,Spain,Italy,Italy,Italy,Spain,Belgium,Sweden,Sweden,Belgium,Greece,Greece,Greece,Croatia,Poland,United Kingdom,Denmark,Luxembourg,Portugal,Denmark,Denmark
Call: Open Innovation Test Beds for nano-enabled bio-based materials (IA) (H2020-NMBP-TO-IND-2020-twostage, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 16721764.96
EU funding (EUR): 14807314.5
Participants: 38
Project status: SIGNED

Recent developments render the biobased sector a key player in European Economy providing a great impetus towards Circular Business Models of resource efficiency. Developments in biobased nanomaterials are coupled with biotechnologies applied to biomass converting the renewable resources into high added-value polymers. BIOMAC will establish an Open Innovation Test Bed (OITB) Ecosystem providing open access to SMEs or Industry to a single-entry point. Starting from the utilization of biomass sources followed by the production of biobased nanoparticles and different building blocks the ecosystem produces biopolymers for the strategic sectors of Food Packaging, Construction, Automotive and Printed Electronics which consist a high market share. A self-sustainable open innovation ecosystem for the upscaling of upscaled processes across the supply and value chain is intended to be created in order fill this gap. Although the last two decades a high number of publications have been only a very limited number of such cases has been finally commercialized and reached the market end users. Some of the reasons that these have not been adopted by the market are lack of investment, funding for further development, upscaling and the limited willingness of end users to adopt nanomaterials into their processes, this is the ‘valley of death’ which BIOMAC intends to overcome. The OITB will offer services that cover the assessment of regulation & safety, sustainability, circularity and market potential among with modeling, process control, standardization and characterization; accessible at fair conditions and cost. BIOMAC establishes a concrete community of open collaboration for stakeholders and customers enabling innovation and minimization of investment risks. This will be achieved by offering an open innovation ecosystem, in which technologies that have been developed up to TRL4-5 will be able to be upscaled and validated up to TRL 7.

Keywords: biopolymers,nanomaterials,multifunctional,predictive,modelling,standardization,open collaboration
MOdular high concentration SolAr Configuration (MOSAIC)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Spain,Spain,Spain,Spain,Spain,Belgium,France,Czechia,Denmark
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2016-RES-CCS-RIA, 2016)
Start date: 2016-12-01
End date: 2021-11-30
Duration (months): 60.0
Total project cost (EUR): 5077733.75
EU funding (EUR): 5077733.75
Participants: 12
Project status: CLOSED

MOSAIC project aims to exceed the goal of the Strategic Energy Technology (SET) Plan - European Commission of producing CSP electricity at a cost below 0.10 €/kWh. To exceed this goal a commercial CSP plant of > 1GW of nominal capacity is foreseen, in which high nominal capacity of CSP plant is reached in a modular way where each MOSAIC module delivers thermal energy to linked thermal energy storage systems that supply their energy to a high capacity power block (>1GW). This modular configuration guarantees reliability, flexibility and dispatchability according to the needs of the electrical grid while reduces significantly the specific cost of the Power block (€/MW installed). Each MOSAIC module consists of an innovative fixed spherical mirror concentrator arranged in a semi-Fresnel manner and an actuated receiver based on a low cost closed loop cable tracking system. This configuration reduces the moving parts of the whole system decreasing solar field cost while keeping high concentration ratios. This will assure high working temperatures thus high cycle efficiencies and a cost effective use of thermal storage systems. Energy from the sun is collected, concentrated and transferred to the heat transfer fluid at module level where, due to the modular concept, distances from the solar concentrator to the receiver are much shorter that those typical from solar tower technologies. As a result, the efficiency of energy collection is maximized, atmospherical attenuation is minimized and accuracy requirements can be relaxed. All these technical benefits contribute to a much lower capital cost of the whole system while keeping efficiency and reliability. This has consequently a strong impact in the final cost of electricity production. First figures show LCOE estimated values below 0.10€/kWh for CSP power plants of 100 MW nominal power based in MOSAIC concept, additional cost reductions are expected for greater capacities (>1GW) exceeding the goal of the SET plan

Keywords: lcoe,spherical concentrator,fixed solar field,modular plant,concentrated solar power,parallel kinematics tracking