Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
XCORE: Low Cost CFRP Production for the Next Generation of Lightweight Cars (XCORE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands,Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-11-01
End date: 2022-01-31
Duration (months): 39.0
Total project cost (EUR): 1733696.25
EU funding (EUR): 1213587.0
Participants: 2
Project status: CLOSED

Today cars are responsible for 12% of the total EU emissions of carbon dioxide (CO2), the main greenhouse gas. European climate policy sets mandatory emission reduction targets for new cars. Car weight reduction with a CFRP chassis is an effective measure to reduce fuel consumption, increase passenger safety and extend the operational range of electric and hybrid vehicles. The mainstream automotive industry has not adopted CFRP for chassis production due to the high costs of CFRP production. Conventional CFRP production technologies produce structural components with an average production cost of 140 €/kg. In order to attain a disruptive shift from steel to CFRP within the mainstream automotive industry a maximum production cost of 30 €/kg has to be achieved. The XCORE production technology uses an expanding foam with gas filled thermoplastic microspheres in a heatable closed mould to create the high pressure necessary for curing (consolidating the CFRP face material), while conventional production is based on expensive autoclave or RTM technology. XCORE production technology reduces the CFRP production investment costs, material costs, operational costs, and labour, and will result in a production cost of only 27 €/kg for CFRP structural components. XCORE will initiate a disruptive shift from steel manufactured cars to CFRP manufactured cars, resulting in a European fuel consumption reduction of 1.21 billion litres representing a €1.17 billion cost reduction for car owners and a CO2 emission reduction of 3.0 billion kg/year. The key market is the European car manufacturing industry, which produces 17.3 million vehicles per year complemented with the US and Asian automotive industries. A demonstration is necessary to convince the automotive sector of the added value of the XCORE technology and opens the market for this innovation. For the Phase 2 project Donkervoort has involved key players to execute the demonstration project and develop the market implementation.

Keywords: lightweight automotive engineering,carbon fiber reinforced plastic,low cost manufacturing,co2 reduction
Application of high-strength steel in offshore wind energy tubular structures (HSS-Wind)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-08
End date: 2021-02-07
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Currently, offshore wind structures are constructed using normal strength steel members with yield strength of around 355 MPa. Larger section sizes are required to resist the higher load levels encountered in progressively deeper waters. This substantially increases cost, complicates logistics, generates installation difficulties, and causes greater environmental impacts. HSS material has the twin advantages of reducing the self-weight of structures and accruing associated cost savings. The installation costs typically represent up to 20% of the capital expenditure of an offshore wind farm. There is a need for more compact and lighter structures that can be easily sited on the seabed by standard installation vessels with lower crane capacity. Furthermore, the use of HSS provides increased structural resilience against strong cyclic loading in deep water environments, and reduces welding time due to reduced wall thickness. The benefit of HSS in static loading capacity is obvious, due to its increased strength. But there is a concern on deformation capacity for HSS connection, due to its lower ductility than normal-strength steel. In addition, the fatigue strength of HSS, especially at welded connections, remains an open question. HSS-WIND will investigate the application of HSS in offshore wind tubular platforms. The tubular joint is a common structural element in offshore wind platforms, and severe cyclic load, induced by wave and wind in the harsh offshore environment, may lead to fatigue fracture and failure at the vicinity of the welds. Reliable estimation of fatigue behaviour and resistance of HSS welded tubular connections constitutes an engineering challenge, essential for the platform structural integrity. HSS-WIND provides the basis of constructing offshore wind platforms using advanced HSS material, thus facilitating further harvest of renewable energy in deeper waters.

Keywords: steel structure,renewable energy,tubular connection
Development of new chemical tools to combat ALS (Combat_ALS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-03-01
End date: 2022-02-28
Duration (months): 36.0
Total project cost (EUR): 224683.2
EU funding (EUR): 224683.2
Participants: 2
Project status: CLOSED

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder that occurs in families, and sporadically in individuals. It was recently discovered that the massive expansion of a GC-rich hexanucleotide in the intron of the gen C9orf72 is its most frequent genetic cause. Many efforts have been dedicated to decipher the mechanisms by which this repeat expansion contributes to the disease. Although not completely understood, the most prominent mechanism suggested is the toxicity mediated by bidirectional transcription of RNA containing expansion of the repeated motif. These transcripts form nuclear RNA foci may sequester RNA-binding proteins (RBPs) leading to a loss of function. Recent investigations have reported on RBPs that specifically interact with quadruplex structures formed by repeat-containing C9orf72 RNAs. All these evidences make C9orf72 a very promising therapeutic target for ALS. This proposal is focused on the development of new therapeutic tools based on targeting C9orf72 repeat-containing RNA. The objective is finding chemical agents able to counteract the toxicity induced by these RNAs. I will explore antisense and siRNA oligonucleotides containing novel chemical modifications with improved properties. I will study their structure, stability and silencing potencies. Moreover, I propose to use new screening methods to find small compounds with good affinity and specificity for C9orf72 repeats. This proposal includes an in-depth study of the binding mode of the most promising ligands by high resolution NMR, and in vivo testing. For this final aim, I will address the generation of human cerebral organoids carrying C9orf72 repeat expansion and their use to test the therapeutic strategies mentioned above.

Keywords: g quadruplex,i motif,c9orf72,2 f ana,antisense therapy,sirna,ligand screening,organoids
Escaping from Flatland by “de novo” Catalytic Decarboxylation Techniques (NOVOFLAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Although cross-coupling reactions have become one of the pillars of modern chemical synthesis, the ability to forge sp3–sp3 bonds with improved flexibility, practicality, predictable site-selectivity, preparative utility, stereocontrol and with nearly zero-generation of waste has eluded chemists for decades, remaining a major challenge and an uncharted cartography in catalytic endeavours. The successful realization of this goal will represent a paradigm shift from the standard logic of organic synthesis in both basic and applied research, as increasing the number of sp3-hybridized carbon atoms has become a necessary goal in the drug discovery pipeline. NOVOFLAT offers a pioneering approach for forging sp3–sp3 linkages via a triple catalytic cascade that enables an unprecedented intramolecular decarboxylation of simple and available carboxylic acid esters with CO2 as the sole byproduct. As ester derivatives simply derive from naturally-occurring carboxylic acids and alcohols, this proposal will allow to rapidly access sp3–sp3 linkages with different electronic and steric requirements, thus providing an invaluable opportunity to streamline the discovery of important architectures with applications across the molecular sciences. Preliminary results demonstrate the feasibility to provide “a la carte” predictable tool that chemists could use to control the site where the sp3–sp3 bond-formation takes place in both aliphatic and cyclic frameworks, even at remote sp3 sites. In addition, our general principle offers an unrecognized opportunity to simultaneously construct sp3–sp3 linkages and control the stereochemistry at remote sp3 sites. In this manner, NOVOFLAT will not only provide new dogmas in retrosynthetic analysis by fundamentally altering the way sp3–sp3 bonds are made, but also open new vistas in “chain-walking” reactions, as the incorporation of chirality throughout the alkyl side-chain constitutes “terra incognita” in these technologies.

Keywords: c c bond forming reactions
Engineering responsive and biomimetic hydrogels for biomedical therapeutic and diagnostic applications (BIOGEL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Austria,Germany,Switzerland,Belgium,Greece,Netherlands,United States,Netherlands,Netherlands,Japan
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3522760.86
EU funding (EUR): 3522760.86
Participants: 13
Project status: CLOSED

BIOGEL is set up to educate young scientists to develop innovative hydrogel chemistries and systems for biomedical applications. The first objective is to provide a platform for young researchers to undergo a well-rounded PhD education, particularly focussed on translational skills for a career focused in biomedical research and medical technology development. The second objective is to engineer functional and responsive hydrogels, which resemble specific properties of the extracellular matrix. The third objective is (i) to enhance the efficacy of medical devices by 2D biointegrative coatings that direct and orchestrate the interface to living cells and tissue and enable improved integration within the body, (ii) to advance therapeutic measures by 3D templates for tissue repair, and (iii) to enable new diagnostic tools by responsive diagnostic hydrogels. BIOGEL follows an international, interdisciplinary, and intersectoral approach organized in 9 and 8 interwoven work and training packages respectively. The training and research parts are focused on synthetic and biohybrid macromolecules to build clinically translatable hydrogels with specific, application directed bioactivities. In order to enable efficient biohybridisation and minimal invasive application, emphasis is set on in situ gelation of precursors that do not affect the viability of cells and living tissue and that can interlink bioactive subunits to stimulate tissue regeneration, and serve as a functional component in biomedical devices. Structural incorporation of such units must be flexible, dynamic, and responsive to stimuli. This is directed to enhance cell behavior and receptor interaction, tailor the mechanical properties, and enable spatial, temporal, and topographical control of functional components. Translational aspects focus on coatings of medical devices, diagnostic hydrogels, cartilage and bone repair, tissue engineering for cardiovascular implants, and nerve regeneration.

Keywords: hydrogels,medical materials,biomimetic materials,tissue engineering,mechanical properties,extracellular matrix,biointerface
Development of a Business Plan for establishment of The Discoveries Centre for Regenerative and Precision Medicine, a new Centre of Excellence in Portugal (THE DISCOVERIES CTR)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Specific Grant agreement
Countries involved: United Kingdom,Portugal,Portugal,Portugal,Portugal,Portugal
Call: Teaming (H2020-WIDESPREAD-2014-1, 2014)
Start date: 2015-06-01
End date: 2016-05-31
Duration (months): 12.0
Total project cost (EUR): 499849.5
EU funding (EUR): 499847.0
Participants: 8
Project status: CLOSED

This proposal aims to develop the necessary endeavours to elaborate a robust and feasible Business Plan that will be the basis for the creation of a new Centre of Excellence in Portugal – The Discoveries Centre for Regenerative and Precision Medicine. It is an initiative of the Portuguese Foundation for Science & Technology, scientifically coordinated by the University of Minho and involving a national partnership formed by the 6 top-ranked Portuguese universities. The new Centre will result from a teaming process with the University College London, an institution of research and innovation excellence from the UK. The experience and expertise of all these entities – future founding members of the new Centre – will be used to design the necessary strategies and approaches to build the final business plan. The Discoveries Centre to be created will perform world-leading research, by anchoring research activities of the best research groups in Portugal, promoting excellence, advanced training, translational research outputs and commercialisation strategies. In the long-run, these are expected to generate an important economic impact, as well as a positive social effect by contributing to the increase of the quality of life of an ageing European population affected by neurodegenerative, cardiovascular and musculoskeletal diseases. Therefore, it is anticipated that The Discoveries Centre will be able to foster a knowledge-based economy aligned with national and regional strategic priority areas and European societal challenges, thus reinforcing Portugal’s scientific capabilities and social and economic development. It will also contribute to a global recognition of the national scientific production, having a structuring effect in the Portuguese science, generating high value-added products, attracting top-level international scientists, as well as enhancing the capacity to retain the best Portuguese researchers.

Keywords: regenerative medicine,precision medicine,bioengineering
European Holocaust Research Infrastructure (EHRI)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Israel,Austria,Germany,Germany,Italy,Belgium,Hungary,Bulgaria,Lithuania,Poland,Belgium,Greece,Romania,Slovakia,France,France,Czechia,United States,Netherlands,United Kingdom,United Kingdom
Call: Integrating and opening existing national and regional research infrastructures of European interest (H2020-INFRAIA-2014-2015, 2014)
Start date: 2015-05-01
End date: 2019-10-31
Duration (months): 54.0
Total project cost (EUR): 7969673.75
EU funding (EUR): 7969673.75
Participants: 24
Project status: CLOSED

The European Holocaust Research Infrastructure (EHRI) project seeks to transform archival research on the Holocaust. The vision of EHRI is to integrate the data, services and expertise of existing Holocaust infrastructures on an unprecedented scale. It will allow researchers from across the globe transnational and virtual access to the integrated infrastructure, and provide them with innovative digital tools and methods to (collaboratively) explore and analyse Holocaust sources. EHRI will thereby become an indispensable tool for the study of the Holocaust from a pan-European perspective. EHRI is based on an advanced community that has already achieved a significant co-ordination of its efforts, not least thanks to the activities undertaken during EHRI's first phase. The aim of the second phase is to further expand this community. The EHRI consortium includes 22 partners, spread across Europe and beyond. This consortium, as well as a network of regional contact points, enables EHRI to reach those regions where much valuable Holocaust source material is located, but where access has hitherto been problematic, especially in South-Eastern and Eastern Europe. EHRI includes measures to build capacity in such regions, thereby ensuring that institutions and people across Europe can contribute to, and make use of, the EHRI infrastructure. EHRI will continue to serve as a 'best practice' model for other humanities projects, and its innovative approach to data integration, management and retrieval will have impact in the wider cultural and IT industries. Although EHRI is geared towards scholarly communities, open online availability of reliable Holocaust material is important for the larger public, as the Holocaust is deeply rooted in the development of European societies. European support for the study of this most traumatic historical event is essential to achieve a comprehensive approach to the history of the Holocaust as a shared European phenomenon.

Keywords: contemporary history,holocaust and genocide,digital humanities,european history
Society behind the Horizon (SOCIETYnext)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy,Italy
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-06-01
End date: 2021-05-31
Duration (months): 12.0
Total project cost (EUR): 198267.5
EU funding (EUR): 198267.5
Participants: 7
Project status: CLOSED

At the dawn of a new decade, fraught with tensions and contradictions, the economic uncertainty hangs over a widespread and acute social inequality, political instability affects vast regions and adds to climatic and environmental emergencies. As a ship caught in a storm, our society needs to find a safe sailing route and hold to it, until calm waters are reached. And as it is the case for sailing, the right direction may be found by looking at the stars, well beyond our everyday horizon. The UN General Assembly provided a useful compass, indicating 17 Sustainable Development Goals to be achieved by 2030 to ensure Prosperity and Peace for People and the Planet thanks to a global Partnership. The SDGs reflect the major global issues, from poverty to health care, from quality education to gender equality, from clean energy to sustainable economic growth, from climate change to environmental degradation. The European Researchers’ Night 2020 organized by SOCIETYnext will show that researchers are among those whose everyday work addresses these challenges. Far from hiding in an ivory tower, researchers are deeply rooted in reality and well aware of its complexities, which so often constitute the very subject of their research. From the early warnings about climate change to the development of strategies for a fair and safe evolution of our society, researchers intervene often in the public debate. When the youth floods the streets of our cities with their worries about the future, it is time for science and research to provide their insights on the great issues of sustainable development. To respond to this societal demand, along with classic edutainment, meant to amuse the public, SOCIETYnext will offer various opportunities for serious discussions about complex issues with competent researchers, engaging participants in a two-way dialogue about priorities and needs that society should address to ensure a sustainable future.

Keywords: public engagement,event,dissemination,cultural heritage,schools,young people,edutainment,gender balance
Novel Electrochemical Exfoliation Approach to the Synthesis of Large Area, Defect-Free and Single Layer Graphene and Its Application in Fuel Cells (GRAPHENERGY3)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-17
End date: 2017-08-16
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Large area, scalable production of single layer and defect free graphene is important for its use in industrial applications. Currently, common methods used to prepare graphene include micromechanical cleavage, chemical vapor deposition, and chemical reduction. However, all these methods have their own shortcomings, for example, difficulty in scale-up or poor quality due to significant defects. To address this issue, in this project, we will focus on developing a novel electrochemical cathodic exfoliation approach to produce high quality graphene. Non-covalent edge-functionalization will be employed to open graphite edges. Upon a negative potential applied on the functionalized graphite electrode, H+ cations from protic ionic liquid electrolyte will be inserted into graphite interlayers and be reduced to hydrogen gas to further open the edge of graphite, which will facilitate the larger imidazolium cations to intercalate, expand and completely exfoliate graphite to single layer graphene. This cathodic exfoliation approach is nondestructive to the resultant graphene, and maintains its perfect structure and electronic properties, which will result in high electrochemical stability and benefit the performance of graphene-based fuel cell electrocatalysts. Finally proton exchange membrane fuel cells will be fabricated with graphene based electrocatalysts above and these are expected to exhibit high power density and long term durability, which may produce a promising future energy technology.

Keywords: graphene,graphite,fuel cells,electrochemical exfoliation,platinum nanoparticles,electrostatic self assembly