Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Functional Lipid−Protein Interactions in Integral Membrane Proteins (Lipopeutics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: CLOSED

Membrane proteins constitute a third of the human proteome and their relevance to disease has led these proteins to make up more than half of all current drug targets. However, despite this push to identify agents for membrane proteins, the number of established disease-associated targets are limited. The 'open' and solvent-accessible nature of most membrane protein orthosteric sites often results in limited specificity of potential drugs. The Trans-Membrane domains (TMD) while displaying greater variability among membrane proteins were however long considered lacking in specific interactions. But significant developments in experimental techniques are now identifying this domain to interact and be actively regulated by the diverse lipid components of the membrane. This Lipopeutics project attempts to determine if the analysis of the protein's Lipid interactions can be a pathway to the development of allosteric drugs targeted at these bilayer-exposed pockets. Unfolding in three major steps, the project first aims to identify specific lipid binding sites with the TMD through the use of long-timescale coarse-grain Molecular Dynamics simulations. Subsequently, the role of this lipid binding event in the protein's functional modulation is validated through atomistic simulations using the Markov State Modelling approach. Finally, cheminformatic screening is used to design lipid-mimicking compounds that are capable of binding within the hydrophobic pocket and stabilizing specific protein functional states.

Keywords: membrane protein,lipid,ion channel,molecular dynamics,allosteric,drug development
Through Her Own Looking Glass: Rethinking ‘Woman’ in Italian Feminist Dramaturgy (FemTHEATRE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-03
End date: 2020-09-02
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Adopting an interdisciplinary approach that combines feminist theory, Italian Studies, and women’s writing for theatre, this project will offer the first full-length investigation of the entwined dynamics between the rise of active feminism in 1970s Italy and the coeval theatrical practice. The twofold research objective represents a novelty with respect to the scant existing criticism on the subject. The study will 1) look at how the dramaturgical served as an ideological vehicle for feminism in rethinking the representation of women’s gender roles and 2) assess the impact of feminist ideology in rupturing established dramatic conventions. To better achieve this scope, it will be articulated on three main grounds: i) contextualisation of feminist theory and practice in Italy ii) philological and theatrical analysis of a wide-ranging corpus of plays produced at the time iii) collection of first-hand testimonies. This project will benefit from a unique blend of competences between the researcher and internationally established experts from the Departments of Italian Studies and Theatre Studies at the University of Milan that, combined with intense training, will allow the researcher to reach a position of professional maturity. While promising to make a significant contribution to academia by developing new knowledge in the field, the project also recognises the importance of the research topic for a wider audience. Particular attention will be given to dissemination and audience development activities, including the realisation of a number of performances intended to raise awareness of feminist issues and the topicality of feminist matters nowadays among theatre audiences and the general public. Whilst focusing on the Italian context, this study will also fill a vacuum in Women’s and Gender Studies by establishing a connection between a historically circumscribed form of artistic output and its sociological and historical context that is hitherto lacking.

Keywords: women s studies,women s writings,feminism,gender theory,italian studies,european theatre studies
Smart collect points as an innovative logistic solution to shorten fruit and vegetables supply chain (ECOLUP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-04-01
End date: 2017-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

ECOLUP is an integrated logistic solution addressed to the fruit and vegetables (F&V) sector that allows to shorten the supply chain and is beneficial for both, producers and buyers. It consists on an online marketplace showcasing fruit and vegetable products, synchronized with a network of smart refrigerated lockers embedded with network connectivity and a deliveries’ management software. Through the online platform, F&V producers sell their products directly to the cities’ stores / restaurants. The producers deliver the orders to the smart refrigerated lockers – strategically located in the city – and the buyers -store/restaurant managers- collect them at the time that best fits their schedules (24/7). The smart lockers’ software exchange data in real-time with ECOLUP Administrator, which automatizes 100% the process. The software sends notifications to the sellers (=producers) when their products are purchased, and the buyers (=stores/restaurants) are as well notified when the order has been delivered. The software assigns automatically a locker to delivery the orders, making the choice according to the order’s size to make an efficient use of resources. Users can open their assigned locker a code sent along with the notifications. Once an order has been collected, the locker’s software informs ECOLUP’s Administrator site to release the payment to the seller. ECOLUP is an innovative solution to shorten F&V supply chain by bridging the logistic and communication gap between producers and stores/restaurants. Thanks to ECOLUP, our users will benefit from higher profit margins, F&V’s carbon footprint and food waste will be reduced. Consumers will enjoy fresher products. ECOLUP is easily replicable and scalable. The first smart refrigerated set of lockers will be located in Madrid in 2020. In the following years, we will extend our market to the main cities in Spain, Italy, France, Germany and The Netherlands, being present by 2023 in 13 different European cities.

Keywords: logistics,food supply chain,marketplace,smart lockers,km 0 food
Ribo-regulators that sense trace antibiotics (DrugSense)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-05-01
End date: 2017-04-30
Duration (months): 12.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Over-usage of antibiotics in the clinic and in agriculture resulted not only in increased drug resistance among pathogenic bacteria, but also in the spread of antibiotics metabolites in the environment and in our food. This poses multiple significant threats, including the development and expansion of multi-drug resistant pathogens. The health and safety risks imposed by the presence of antibiotics in food, drinking water, and environmental waters raise the strong necessity for continuous monitoring of trace antibiotics levels in multiple media. The EU now obliges food manufacturers to test for antibiotics traces in their products, but current technologies for antibiotics sensing do not provide a complete solution. There is a strong need for antibiotics sensors that would accurately, rapidly and inexpensively report on the presence of antibiotics in various environments. In our ERC-StG project we discovered new RNA leaders (ribo-regulators) that sense very low concentrations of antibiotics, leading to the activation of antibiotics resistance genes. These ribo-regulators thus function as efficient antibiotics sensors. Within the current PoC project we will develop a prototype for a highly sensitive bio-sensor, capable of rapid detection of trace levels of multiple antibiotics in food, water and other substances in a cost-effective manner. Our PoC project involves both prototype development and business development. Within the prototype development we will utilize our earlier discoveries to bio-engineer the antibiotics sensor. Within the business development arm we will perform a thorough market research to identify the market needs, map the competition and pinpoint market segments where our biosensor product would have an advantage over the competition. Our aim is to achieve an IP protected proof of concept prototype that will attract further external investments, leading to spawning of a start up company that will bring our technology to the market.

Keywords: antibiotics,sensor,ribo regulator,bacteria
Improving energy efficiency and reducing carbon emissions by utilization of ultra-cold energy from the regasification of liquefied natural gas (LNG) (LNGCOLD)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Germany
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cost-efficient and environment friendly provision of cold for industry, food handling, shipbuilding, and LNG (Liquefied Natural Gas) fuelled trucks is a rapidly growing market opportunity. Electrical refrigeration and air-conditioning consume almost 25% of the electrical energy in Europe, a tremendous saving potential and attractive business opportunity for new technologies. Eco ice Kälte GmbH develops technologies to exploit this attractive market potential, to generate significant growth and with this contribute to achieving the climate targets. One very promising approach results from the globally rising use of LNG as energy source, since a huge cold capacity at -162°C is stored in LNG, which is hitherto completely wasted during the regasification by heat exchange with ambient air or sea water at port terminals and LNG end user’s sites, respectively. Eco ice has developed and patented an innovative technology (TRL6) in various output classes to recover this highly valuable cold capacity without additional electrical power or gas consumption and provide it very cost-efficiently to the market. The Eco ice technology has the potential, without any self-consumption of natural gas, to create electrical power savings of 5.000 MW, i.e. to replace the fossil fuels for several large power stations. The cold market is increasingly looking for such cost-efficient and eco-friendly alternatives, as confirmed by customer feedback. Even in a conservative business scenario, which assumes a technology conversion rate of only 5%, a profitable short term growth up to a high two digit million € revenue value can be expected, as confirmed by ongoing negotiations with potential launching customers and business partners. The proposed feasibility study aims at completing the market study, concretising the business plan and developing an optimised business model and sales plan starting with already initiated business partnerships.

Keywords: energy efficiency,carbon footprint reduction,ultra cold energy recovery,liquefied natural gas lng,heat,cold,deep cold,electricity saving,cogeneration of cold,heat and electricity
Forthcoming Research and Industry for European and National Development of SHIP (FRIENDSHIP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Germany,Norway,Slovenia,Sweden,France,France,Czechia,Portugal,Portugal
Call: Solar Energy in Industrial Processes (H2020-LC-SC3-2019-NZE-RES-CC, 2019)
Start date: 2020-05-01
End date: 2024-04-30
Duration (months): 48.0
Total project cost (EUR): 4999423.74
EU funding (EUR): 4999423.74
Participants: 12
Project status: SIGNED

Solar heat is already used for Agro-Food industrial processes, mainly under 120°C. The FRIENDSHIP project will aim to demonstrate that solar heat can also be a reliable, user-friendly, high quality and cost-effective resource to meet the heat requirements for other industrial sectors as Textile, Plastics, Wood, Metal and Chemistry. To this end, the project plans to bring together research centres, industry leaders, technologies & heat suppliers into the same consortium in order to unite skills towards the boost and control of the heat supply temperature according to processes needs.Different coupling of technological and control innovations will be investigated: optimization of heat transfer coefficients; coupling and reliability of different solar technologies; introduction of high-temperature heat pumps; combined heat storage bringing flexibility on both solar and process loops with guarantees of continuous operation as well as plug-and-play integration; thermal chillers for cooling demand; and smart control to ease operation of the overall installation according to the process specifications. The proposed systems will be able to supply together heat at temperature up to 300°C and negative cold at temperature down to -40°C. In order to guarantee the replicability and scalability of the proposed demonstration, specific work will be carried out with world-class industries involved in the consortium (regulatory studies, financial incentive schemes, local energy markets creation), especially turned towards relevant users cases: industrial sites and parks in European countries where solar heat is currently underused.Ultimately, the project will evaluate to what extent high share of solar heat heating and cooling will allow to reduce the dependence of industrial processes on carbon energies and associated polluting emissions, and to quantify economic gains related to the use of solar energy in a context of a changing fossil fuel market and changing climatic constraints.

Keywords: solar heat industrial processes,ship,decarbonisation,spire,bref,heating,cooling,solar thermal
Laser Lightning Rod (LLR)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Switzerland,Switzerland,Switzerland,France,France,France,France
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2021-12-31
Duration (months): 60.0
Total project cost (EUR): 3962500.0
EU funding (EUR): 3956500.0
Participants: 10
Project status: CLOSED

Controlling lightning is a long time dream of mankind. The goal of the present project is to investigate and develop a new type of lightning protection based on the use of upward lightning discharges initiated through a high repetition rate multi terawatt laser. The feasibility of the novel technique and the project’s prospect of success are based on recent research providing new insights into the mechanism responsible for the guiding of electrical discharges by laser filaments, on cutting-edge high power laser technology and on the availability of the uniquely suitable Säntis lightning measurement station in Northeastern Switzerland. The LLR consortium is ideally positioned to succeed and to raise the competitiveness of Europe in lightning control as it relies on the integration of trans-disciplinary fields in laser development, nonlinear optics, plasma physics, remote sensing, and lightning: The project team is made up of leaders in the domains of high power nonlinear propagation of laser pulses in the atmosphere, laser control of electric discharges, lightning physics, high power laser development, and high-repetition-rate lasers. In addition, the largest European company in aeronautics brings its expertise in lightning direct effects and protection means on aircraft and infrastructures.

Keywords: lightning initiation,filamentation control in atmosphere,high power thin disk laser
Understanding and improving human motivational capacities: A focus on glutathione in the ventral striatum (LGCMOT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Motivation -the process that facilitates overcoming the cost of effortful actions to attain desired outcomes- is key to achievement and well-being. Importantly, there are major individual differences in motivational levels. Low motivation can reflect states of fatigue or depression not only in patients, but also in the general population, and there is currently no effective treatment to ameliorate this condition. Understanding the brain mechanisms linked to variation in motivated behavior will be of utmost importance to advancing treatments. Brain metabolism in the ventral striatum -a brain’s motivation hub- is emerging as a strong regulator of motivated behaviors. Strong pilot data from the host lab has underscored a striking correspondence between glutathione (GSH) - the most prominent antioxidant – levels in the ventral striatum and motivate on the prediction of effort-based motivated behavior. However, solid evidence is still lacking. The goal of this proposal is to determine whether GSH levels in the ventral striatum relate to widespread levels of effortful performance in healthy human subjects. To this end, I will use a combination of high-field (7T) 1H-Magnetic Resonance Spectroscopy (1H-MRS; to quantify GSH levels in the ventral striatum, and in the occipital cortex as control region), functional Magnetic Resonance Imaging (fMRI; focusing on BOLD activity in the ventral striatum), behavioral testing for physical and cognitive effort-based motivation, and computational modeling (allowing to dissect specific motivational components). In addition, a 7-days nutritional intervention (N-acetyl-cysteine or placebo) to manipulate the GSH system will be tested for its effectiveness to 1) increase striatal GSH levels; and 2) improve specific aspects of motivated behavior (e.g., incentive valuation, effortful performance) in the physical and/or cognitive effort tasks. Therefore, LGCMOT outcomes will greatly advance knowledge in the emerging field of neurometabolism.

Keywords: motivation,glutathione,n acetyl cysteine,spectroscopy,neuroimaging
Ecosystem building blocks for the Next Generation Internet movement (NGI MOVE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Spain,Austria,Netherlands,Denmark
Call: Next Generation Internet (H2020-ICT-2017-1, 2017)
Start date: 2017-10-01
End date: 2019-03-31
Duration (months): 18.0
Total project cost (EUR): 699593.75
EU funding (EUR): 699593.75
Participants: 4
Project status: CLOSED

We are yet again at a critical stage for Europe. With the threat of geopolitical instability coming from several dimensions Europe needs to not just assert its presence on the world stage, but moreover needs to assert its digital sovereignty to further its vision of a single digital market. The need for a European leadership role for the Next Generation Internet is clear. NGI MOVE is to inspire Europe to become a leader in the co-creation of the NGI in a more human centric, societal and economic beneficial ecosystem of researchers, high tech start-ups, industrial and government leaders as well as grassroots communities and individuals. The vision is to create a NGI that is at the service of people and stimulates business opportunities, centred on European values and competing globally. Our message is pragmatic cybernetics, balancing extreme centralisation and extreme decentralization where data stays with citizens. The main activities of the project are driven by the following activities: Connecting the Next Generation Internet Ecosystem is the primary activity, in that it identifies and engages with the most brilliant researchers, entrepreneurs and individuals. Co-creating the Next Generation Internet Ecosystem is all about creating content that fuels the community and motivates people to engage. Three sub-activities are to co-create: (1) the organisational model around the NGI flagship initiative. (2) the concepts and models that make up the characteristics for the NGI flagship initiative. (3) a number of NGI scenarios that can drive a vision and common basis for discussion amongst the many diverse stakeholders. The final activity is to launch the NGI Ecosystem. In essence this is the tangible outcome of the project that provides the basis for the NGI flagship initiative beyond H2020. In essence it delivers a brand, a model organisation and set of tools to support the ecosystem as well as the people that are active participants in shaping the NGI.

Keywords: next generation internet,ecosystem,coordination and support action,internet of things