Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Artificial Intelligence for optimisation of Fuel Injection Equipment suitable for carbon-neutral synthetic fuels (AI-FIE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2025-01-31
Duration (months): 36.0
Total project cost (EUR): 271732.8
EU funding (EUR): 271732.8
Participants: 2
Project status: SIGNED

Current EU policies mandate the gradual disengagement of the transport sector from fossil fuels. In order for such a transition to become a reality, hydrogen-derived carbon-neutral synthetic fuels produced using renewable energy sources (e-fuels), have overall less life-cycle CO2 footprint than their counterpart electric vehicles while they are suitable for use over the wide range of combustion engines. However, today’s fuel spray experimental methods are compromised by the long time needed for the characterisation of the effect of new fuel molecules; similarly, relevant predictive models that can address in detail the effect of the wide range of fuel chemical composition at time scales relevant to industry are not available. The main objective of the proposed MSCA fellowship is the development of a data-driven deep learning (DL) Artificial Intelligence (AI) algorithm able to predict the spatially and temporally resolved spray structure, as well as critical air / fuel mixture parameters for engine design. Training of the AI model will be based on the largest publicly available experimental database for fuel sprays of the Engine Combustion Network; this covers a wide range of injector configurations, air thermodynamic conditions and liquid fuels. The training matrix of the AI algorithm will be complemented by relevant computational fluid dynamics simulations for operating conditions and fuel composition for which experimentation is not possible. For this purpose, a state-of-the-art CFD model of the compressible Navier-Stokes and energy conservation equations employing elaborate real-fuel thermodynamic closures based on the PC-SAFT equation of state will be employed. The project innovative nature spans across diverse research aspects with emphasis on renewable alternatives of Diesel and gasoline. As such, it is expected to assist EU energy, marine, aviation and automotive industries to meet the goals imposed regarding the utilisation of renewable fuels.

Keywords: e fuel,pc saft,fuel spray,nozzle flow
Probability of real-valued events: a logico-algebraic investigation (PROREAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

The goal of this project is to develop logico-algebraic and measure theoretical techniques to study the probability theory of real-valued events. The classical approach to probability only allows the study of events that at some moment will either be verified or not. In more logical terms, they will become either true or false. In order to be able to treat the intrinsic vagueness of real-life declarative statements, we will study events whose truth-value can be intermediate, varying in the real unit interval (where 0 represents absolute falseness and 1 absolute truth). Our focus will be on the state theory, i.e. probability theory, of continuous (or more generally left-continuous) t-norm based fuzzy logics. The study will be carried out by the point of view of the algebraic semantics of such logics, which has proven to be extremely fruitful in recent years, showing interesting connections to measure theory. Indeed, in different fuzzy logics it is possible to introduce a notion of probability map on the algebras of formulas in such a way that it axiomatizes the Lebesgue integral of the formulas (which, thanks to universal algebraic results, can be seen as real-valued functions). As a most challenging goal, we will investigate the minimal properties for a logic to allow the axiomatization of a probability theory axiomatizing the Lebesgue integral of formulas. Moreover, as in recent years the artificial intelligence perspective is emerging, we will develop logical frameworks for many-valued probabilistic reasoning, and study the satisfiability of the probabilistic assertions for such logics. The study will strongly ground on preliminary work of research the fellow has conducted in recent years. Moreover, it will benefit from the broad experience of the supervisor as a leading researcher in the field, and of the high level, multidisciplinary environment of the hosting institute.

Keywords: residuated lattices,bl algebras,basic logic,mv algebras,state theory,measure theory,mathematical fuzzy logic
Flexible and User-defined Technologies for Unconstrained neural Recording Experiments in Non-Human Primates (FUTURE-NHP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany,Italy
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 92500.0
Participants: 2
Project status: CLOSED

Some of the greatest today’s challenges in understanding human brain functions and dysfunctions are being tackled by using Non-Human Primates (NHPs), a unique and still unreplaceable model in neurophysiology because of their remarkable anatomo-functional, cognitive and behavioural similarities to humans. Tethered neural recordings have been, so far, the virtually unique methodology available for these studies. Nonetheless, this approach 1) limits the range of behaviours and functions that can be investigated, 2) reduces the ecological validity of the results and 3) increases the public ethical concerns about the use of NHP, challenging the future of this still fundamental branch of science. This project (FUTURE-NHP) capitalizes on the preliminary findings of the ERCstg grant WIRELESS, in which we are developing a new approach to brain studies in freely-moving NHP with wireless technologies and video behavioural monitoring. The aim of FUTURE-NHP is the fabrication and pre-commercial testing of a new, 3D printed cranial device, allowing to easily and flexibly perform semi-chronic neural recordings from a fully customizable and interchangeable sets of multielectrode probes. With our partner SME we will perform, in parallel, a detailed evaluation of commercial opportunities for the developed device in a global (not just EU) perspective using clear IPR constructions and strategies. Furthermore, we will implement a software platform allowing end- users to design customized layouts of the device for custom-specific applications. The device will be optimized for (but not limited to) wireless recording experiments and will be made compatible with different types of probes and recording systems. By extending the range of affordable neuroscientific questions to unconstrained behaviors, FUTURE-NHP will improve the ecological validity of neurophysiological data and their translational value for humans, and contribute to make more ethically acceptable NHP fundamental research.

Keywords: primate neurophysiology,neural recording devices,silicon probes,neuroengineering
Hidden in plain sight: Masking RNA Pol II phosphorylation via proline isomerization during gene expression (Iso-Proline CTD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-11-15
End date: 2024-11-14
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: SIGNED

Prolines are unique amongst aminoacids given that they naturally exist in two isomeric states: CIS and TRANS. The transition between these states is slow but can be catalyzed by the activity of proline isomerases such as PIN1. Recent in vitro work suggests that PIN1 can alter the phosphorylation dynamics of the C-terminal domain (CTD) of RNA polymerase II (Pol II) by inhibiting phosphatase recognition. Given Pol II is solely responsible for transcribing all protein-coding genes and that CTD phosphorylation dictates the timing of RNA co-transcriptional processes, these observations suggest a crucial role for CTD proline isomerization in gene expression. Importantly, mutations in PIN1 are associated with cancer progression but a direct role for proline isomerization has remained understudied given the technical limitations imposed by its complex enzymology, such as the inability of differentiating CIS and TRANS isomers using Mass Spectrometry. In this project, I aim to functionally dissect the role of proline isomerization during Pol II transcription using rigorous biochemical, cellular and genomic techniques. Specifically, I will exploit new technological advances in peptide synthesis to permanently “lock” prolines in CIS or TRANS and identify novel isomer-specific interacting factors. I will systematically examine the consequences of CTD proline mutations and of rapid depletion of PIN1 in human cells, focusing on CTD-dependent co-transcriptional RNA processes such as splicing and poly-A–dependent 3’ termination. At the basic research level, my results will provide unprecedented resolution to the dynamics of Pol II phosphorylation, which underlies regulation of gene expression in multicellular organisms. Translationally, given that various cancers hijack the transcriptional programmes of the cell, this mechanistic understanding of CTD proline isomerization will better equip future clinical studies interested in the yet-to-be-characterized role of PIN1 in oncogenesis.

Keywords: rnapii,pol ii,gene expression,proline isomerization,ctd phosphorylation,genomics,pin1,mechanistic analysis,nascent rna transcriptomics,silac,proteomics,immunoprecipitation,degron
Specialized Ribosomes for Neuronal Protein Synthesis (NeuroRibo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-08-01
End date: 2022-07-31
Duration (months): 60.0
Total project cost (EUR): 2348483.0
EU funding (EUR): 2348483.0
Participants: 1
Project status: CLOSED

The ability of the nervous system to respond adaptively relies on modifications to existing proteins as well as changes in gene transcription and mRNA translation. It is now clear that synapses possess the capacity for local protein synthesis, owing to the localization of ribosomes and mRNAs within dendrites. There is emerging interest in the possibility that ribosomes, as cellular machines, are not as static as typically assumed- and may be heterogeneous in composition and specialized for particular functions and cellular compartments. Intriguingly, several studies have noted the presence of ribosomal protein mRNAs in the dendrites and axons, raising the possibility that locally synthesized ribosomal proteins might serve to modify the local ribosome population. Amongst the players in protein synthesis, many signaling proteins, RNA-binding proteins, and most translation factors have been considered as potential regulatory hubs. The ribosomes, thus far, have not been considered. Here we propose to discover the nature and diversity of ribosomes present in neurons, their dendrites and their synapses in the rodent brain. Using a combination of RNA-sequencing, Mass Spectrometry, Fluorescence In situ Hybridization, and new labelling approaches to visualize nascent proteins, we will determine whether neuronal ribosomes are heterogeneous and specialized in different subcellular compartments. The proposed experiments will determine the relationship between the ribosome composition and the neuronal mRNAs that undergo translation. We will also examine how plasticity sculpts the ribosome population to regulate the changes in the proteome that are dynamically regulated by ongoing synaptic events and plasticity.

Keywords: 1 dendritic protein synthesis,2 dendrite,3 synaptic plasticity
How consciousness is shaped by neuronal network dynamics (CONSCBRAIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

How does the structure of the brain give rise to its function? We will address this longstanding neuroscience question through an interdisciplinary research project, by using computational modelling to study the neuronal dynamics which underlies the specific brain function of consciousness. More precisely we propose to investigate the differences in neuronal dynamics between conscious and unconscious brain states, and how conscious experience is shared across subjects watching a movie. The project capitalizes on using whole brain models that are constrained by anatomical and functional connectivity data from humans and non-human primates. In a first study, we will test whether differentiation of brain activity, as indicated by homogeneity differences of functional connectivity patterns across the modelled brain areas, can serve as a marker of consciousness. In a second study we will construct a whole brain model of experiments in which subjects synchronize their brain activity when watching a natural stimulus such as a movie. Through external stimulation of the model we will determine the set of brain areas that is causally involved in driving this synchronization of conscious experience. The results will give new theoretical insights on how neuronal interactions at an entire brain’s scale are informative of consciousness and shared conscious experience across subjects.

Keywords: consciousness,whole brain modeling,neuronal network dynamics,synchronization and desynchronization
Learning to enhance exploitation potential of SME project results (LEEP-SME)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain,Spain,Belgium,Czechia
Call: Peer learning of innovation agencies (H2020-INNOSUP-2018-2019-05, 2019)
Start date: 2020-07-01
End date: 2021-06-30
Duration (months): 12.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 4
Project status: CLOSED

SMEs highly benefit from successful research that results in applicable solutions. It is either by monetizing their own innovative solutions or by cooperating with a research organization and bringing the shared results onto the market or other space for exploitation. In order to help this process by employing public funding and supporting activities, it is important to be able to detect and evaluate exploitation potential in research projects that are to receive the support. The partners of this project are public organizations supporting applied research by funding and assistance. They believe that in order to positively influence the research-driving SMEs and research-implementing SMEs, it is essential to be able to evaluate projects from the perspective of exploitation (or in other words application) potential. Specifically, it is key to be able to, first of all, select the most promising project proposals for support (the proposals with the highest exploitation potential) and, second, help them to successfully finish their projects and implement their results by interim and ex-post monitoring complemented with support services. Therefore, this project’s goal is to build a peer-learning group and share each other’s best practices and experiences and apply them in practice in order to improve project partners’ proposal-evaluation and project monitoring skills in terms of exploitation potential. This improvement could lead to higher success rate of the projects and their better impact assessment (Alves Ribeiro, 2015). Finally, the project also has a goal to disseminate its results among other research and innovation supporting organisations in Europe.

Keywords: exploitation potential,application of research results in practice,application potential,evaluation,interim monitoring,ex post monitoring
Next-generation biopharmaceutical downstream process (nextBioPharmDSP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Innovation actions
Countries involved: Austria,Germany,Austria,Italy,Slovenia,France
Call: Downstream processes unlocking biotechnological transformations (H2020-LEIT-BIO-2014-1, 2014)
Start date: 2015-03-01
End date: 2019-02-28
Duration (months): 48.0
Total project cost (EUR): 10521448.0
EU funding (EUR): 8366432.5
Participants: 7
Project status: CLOSED

The scope of the project is the optimization of downstream process (DSP) for the production of Biopharmaceuticals. Biopharmaceuticals have been successfully used as efficient therapeutic drugs for many pathophysiological conditions since the first recombinant product, insulin, was approved in 1982. Despite its efficacy, accessibility is still limited due to extremely high costs. In the production chain, capturing and purifying still represents a major bottleneck. Consequently, improvements in this area produce substantial cost reductions and expand patients’ accessibility to highly efficient drugs. Another aim of this action is to cope with the changing manufacturing demands, by lowering its environmental footprint and moving to more sustainable technologies. This proposal’s main objective is to implement a fully integrated manufacturing platform based on continuous chromatography in combination with disposable techniques for all unit operations of the DSP sequence for biosimilar monoclonal antibodies and derivatives thereof. The action encompasses the entire DSP sequence. We will implement alternative technologies for primary separation, such as flocculation or tangential flow filtration. The expected outcome is a reduction in the size and number of downstream unit operations and the elimination of centrifugation. Alternative approaches to the batch process for the capture step, such as continuous chromatography, will be evaluated in order to improve the efficiency and lower the need for expensive resin volume. Additionally precipitation utilization will be evaluated as an approach to replace protein A chromatography as capture step. A disposable continuous chromatography system will be developed together with novel analytical tools and sensors. Since single-use disposable systems can substitute the extensive use of resources (water) and significantly reduce the overall utility needs, the whole DSP sequence will be carried out on disposable technology (PAT).

Keywords: continuous chromatography,biosimilars,downstream process,disposable,single use equipment,advanced analytical tools,monoclonal antibody,cost efficiency,environmental footprint
Endoscopic versatile robotic guidance, diagnosis and therapy of magnetic-driven soft-tethered endoluminal robots (Endoo)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Italy,Germany,Italy,Italy,United Kingdom,United Kingdom
Call: Robotics (H2020-ICT-2015, 2015)
Start date: 2015-12-01
End date: 2019-05-31
Duration (months): 42.0
Total project cost (EUR): 3049410.71
EU funding (EUR): 2735937.5
Participants: 9
Project status: CLOSED

The Endoo project (Endoscopic versatile robotic guidance, diagnosis and therapy of magnetic-driven soft-tethered endoluminal robots) aims at developing an integrated robotic platform for the navigation of a soft-tethered colonoscope capable of performing painless diagnosis and treatment. Colorectal cancer is one of the major causes of mortality but survival rate dramatically increase in case of early diagnosis. Current screening colonoscopy is limited due to a variety of factors including invasiveness, patient discomfort, fear of pain, and the need for sedation; these factors consistently limit the pervasiveness of mass screening campaigns. Built around a novel robotic colonoscope and designed to make its use straightforward for the endoscopist and ideal for mass screening, the Endoo system has the potential to introduce in the clinical practice a disruptive new paradigm for painless colonoscopy. Endoo combines a “front-wheel” magnetic–driven approach for active and smooth navigation with diagnostic and therapeutic capabilities for overcoming the limitations of current colonoscopy in terms of patient discomfort, dependence on operator skills, costs and outcomes for the healthcare systems. The acceptance and consolidation of robotics in the medical domain and the ever–growing development of endoscopic–driven technologies are the fundamental building blocks for the realization of the Endoo platform which can take advantage of solid and IPR protected technologies provided by the Project Partners. Aim of the Endoo Project is to bring the system to the market for an extensive clinical use. The Endoo Consortium is a unique blend of internationally recognized European pioneers (in all the involved disciplines), which will guarantee a dramatic leap forward in the current technology through successful implementation in terms of scientific innovation, industrial engineering, certification, market analysis, and ultimately clinical deployment.

Keywords: colonoscopy,colorectal cancer,robotic endoscopy,soft tethered colonoscope,advanced colonoscopy,magnetic driven active colonoscopy