Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Targeting G-quadruplex DNA Structures in Bacteria to Combat Antimicrobial Resistance (G4-AntiBac)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-06
End date: 2023-04-05
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

There is a pressing need to develop new antimicrobial approaches to combat bacterial resistance to antibiotics. Pseudomonas aeruginosa – a dreadful Gram-negative bacterium pathogen associated with severe acute and chronic human diseases – is responsible for 10-15 % of hospital-acquired infections worldwide. Thus, it is important to identify new biomolecular targets in bacteria and design new molecules that can selectively target them. This project aims to study G-quadruplex DNA (G4 DNA) structures as a new bio-molecular target for the development of new classes of antibiotics. G4 DNA is a non-canonical structure of DNA whose formation has been associated to a number of important biological processes. While the function of G4 DNA is well established in eukaryotic cells, far less is known about their functions in bacteria. Preliminary data from the host group has shown that G4 DNA’s can form in gene promoter regions of the genome in P. aeruginosa. They have also shown that metal complexes can bind to this G4 DNA regions and display antibacterial activity. In this project, I propose to develop novel compounds (via a ‘target-guided synthesis’ approach) that can specifically bind with high affinity to G4 DNA structures of relevance to bacteria. If the newly developed bacterial G4 DNA binders exhibit low cellular uptake, I propose to implement the well-established liposomal delivery strategies to improve their uptake into the targeted bacterial strains. Finally, the highly active compounds will be used to study the proposed gene regulatory role that G-quadruplexes play in P. aeruginosa. My proposed research falls under one of the key priorities (i.e. Infectious diseases and improving global health) of the Horizon-2020 work programme. The outcome of the proposed study will have impact in addressing one of the key objectives (i.e. Develop New Therapeutics and Alternatives) of the recently documented ‘European One Health Action Plan against Antimicrobial Resistance’.

Keywords: quadruplex dna
Plasma Additive Layer Manufacture Smoothing Technology (PALMS)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Italy,France,United Kingdom,United Kingdom
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2016-1, 2016)
Start date: 2017-07-01
End date: 2021-02-28
Duration (months): 44.0
Total project cost (EUR): 2482040.75
EU funding (EUR): 1953975.28
Participants: 5
Project status: CLOSED

Additive manufacturing (AM) offers unprecedented design freedom and the possibility to produce lightweight optimised components that are impossible to make with traditional techniques; or bespoke components that would otherwise be prohibitively expensive if produced in small volumes. Despite the significant progress made in AM, the surface roughness of parts produced by this method continues to be an issue. Rough surface finish on AM parts causes wear, corrosion and fatigue, micro-cracks, poor tolerances, and is aesthetically displeasing. These negative characteristics often outweigh the positive ones of unlimited complexity of shapes and weight reduction benefits. Post-processing finishing methods exist for reducing roughness, but these can be costly and have limited effectiveness, particularly in relation to complex, high surface roughness components. As a result, the application of AM parts in industry is being constricted, particularly in the aerospace and medical industries, where the surface finish of components is highly critical. We have developed PALMS (Plasma Additive Layer Manufacture Smoothing), an innovative cost-effective macro-polishing solution based on novel electrochemical plasma technology. The macro finish (10-50µm) AM parts are rapidly treated in a highly controlled manner in less than 20 minutes, leaving a uniform, smooth micro-finish (<0.1µm), resulting in considerably improved aesthetics and mechanical performance. Our participation in the FTI programme, will allow us to accelerate the commercialisation process for the PALMS TRL6 technology and undertake innovation from the demonstration stage through to market uptake within 32 months after project start. In doing so, we will capture up to 3.0% of the global market by year 5 post project, generating combined revenues of over €68million with an IRR return on investment of 1063%, and the creation of over 160 new jobs.

Keywords: additive manufacturing,3d printing,am parts,post processing,surface polishing,surface finishing,factories of the future,advanced manufacturing,resource efficient manufacturing
Trans-Spin NanoArchitectures: from birth to functionalities in magnetic field (TSuNAMI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Czechia
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2022-07-31
Duration (months): 66.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1014250.0
Participants: 2
Project status: CLOSED

Control over electrons in molecules and periodic solids can be reached via manipulation of their internal quantum degrees of freedom. The most prominent and exploited case is the electronic spin accommodated in standalone spin units composed of 1 – 10^5 of spins. A challenging alternative to the spin is the binary quantum degree of freedom, termed pseudospin existing e.g. in two-dimensional semiconductors. The aim of the proposed research is to build prototypes of trans-spin nano-architectures composed of at least two divergent spin entities, the TSuNAMIes. The spin entities of interest correspond to single atomic spin embedded in spin crossover complexes (SCO), molecular spin of molecular magnets (SMM), superspins of single-domain magnetic nanoparticles (SuperS) and pseudospins in two-dimensional transition metal dichalcogenides (PseudoS). Ultimate goal of the project is to identify a profit from trans-spin cooperation between the different spin entities coexisting in a single TSuNAMI. Influence of external static and alternating magnetic fields on the elementary spin state, unit cell magnetic structure, long-range magnetic order, mesoscopic spin order, spin relaxations and pseudospin state mirrored in essential fingerprints of the spin units and their ensembles will be explored using macroscopic and microscopic in situ and ex situ probes, including Raman and Mössbauer spectroscopies in magnetic field. Within the proposed high-risk/high-gain trans-spin strategy, we thus expect: 1. Enhancement of magnetic anisotropy in SMM-SuperS with enormous impact on cancer therapy using magnetic fluid hyperthermia, 2. Control over SCO via coupling to giant classical spin giving rise to miniature ‘on-particle’ sensors, 3. Mutual visualization of electronic states in SCO-PseudoS pushing frontiers of nowadays pseudospintronics, and 4. Control over electronic states with nanometer resolution in SuperS-PseudoS giving rise to novel functionalization strategies of graphene successor.

Keywords: spin cooperation,spin crossover,molecular magnet,superspin,pseudospin,magnetic nanoparticle,two dimensional materials,spectroscopies in magnetic field,quantum computing,hyperthermia
Enterprise Lazio and Sardegna for Europe – Smes Innovation Management (ELSE - SIM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Italy,Italy
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 223695.64
EU funding (EUR): 223695.64
Participants: 9
Project status: CLOSED

The action “Establishing services enhancing the innovation management capacity of SME's in the Enterprise Europe Network" represents an important breakthrough in delivering the EEN services. Until now the EEN consortia partners’ role was mainly catalyzing the SMEs innovation needs with the innovative product, services and processes provided by other companies or research centres, with the aim of fostering their internationalization. Strengthening the target of internationalization, the EEN consortia partners will improve their action providing on site support to SMEs, and becoming a part of the companies for assessing their capacity in the innovation management issues. The ELSE – SIM (Enterprise Lazio and Sardegna for Europe- SMEs Innovation Management) consortium as a whole is able to provide the expected services: Key Account Management • Assess SME gaps and needs, • Facilitate the identification and the initial coach-SME interaction to prepare coaching plan, • Support companies in the project management and administration Enhancing SME innovation management capacity , • Asses innovation management capacity based on performance, • Action plan implementation.

Keywords: innovation,internationalization,innovation management,eimc,sme enhancing,action plan,coach,coaching plan,needs analysis
PHotonic REServoir COmputing (PHRESCO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Belgium,Switzerland,Belgium,France
Call: Generic micro- and nano-electronic technologies (H2020-ICT-2015, 2015)
Start date: 2015-11-01
End date: 2019-10-31
Duration (months): 48.0
Total project cost (EUR): 3443592.5
EU funding (EUR): 2444512.0
Participants: 5
Project status: CLOSED

New computing paradigms are required to feed the next revolution in Information Technology. Machines need to be invented that can learn, but also handle vast amount of data. In order to achieve this goal and still reduce the energy footprint of Information and Communication Technology, fundamental hardware innovations must be done. A physical implementation natively supporting new computing methods is required. Most of the time, CMOS is used to emulate e.g. neuronal behavior, and is intrinsically limited in power efficiency and speed. Reservoir computing (RC) is one of the concepts that has proven its efficiency to perform tasks where traditional approaches fail. It is also one of the rare concepts of an efficient hardware realization of cognitive computing into a specific, silicon-based technology. Small RC systems have been demonstrated using optical fibers and bulk components. In 2014, optical RC networks based integrated photonic circuits were demonstrated. The PHRESCO project aims to bring photonic reservoir computing to the next level of maturity. A new RC chip will be co-designed, including innovative electronic and photonic component that will enable major breakthrough in the field. We will i) Scale optical RC systems up to 60 nodes ii) build an all-optical chip based on the unique electro-optical properties of new materials iii) Implement new learning algorithms to exploit the capabilities of the RC chip. The hardware integration of beyond state-of-the-art components with novel system and algorithm design will pave the way towards a new era of optical, cognitive systems capable of handling huge amount of data at ultra-low power consumption.

Keywords: new computing paradigms,neuromorphic computing,novel interconnect architectures
Study of telomere function in germ cells, relevant to the regulations of homologous recombination and telomere length maintenance across generations (Meiotic telomere)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The length of telomeric DNA is a critical determinant factor for aging and cancer development. In germ cells, the activation of a telomerase-dependent telomere-lengthening pathway is thought to be important in order to maintain telomeric DNA across generations, but the molecular mechanisms involved in this pathway, i.e: how and when telomerase is activated in germ cells, are largely unknown. A DNA-binding protein complex called shelterin constitutively binds telomeric DNA. However, my recent studies have suggested that a multi-subunit DNA-binding complex, TERB1-TERB2-MAJIN, takes over telomeric DNA from shelterin in mammalian germ cells in order to facilitate homologous recombination. These findings represent a hitherto unknown molecular mechanism at work on the telomeres in germ cells. In this project, I hypothesize that the drastic reformation of telomere-binding complexes in germ cells contributes also to the telomere-lengthening pathway. The aim of this project is to test this hypothesis in order to reveal the mechanism underlying the transgenerational inheritance of telomeric DNA throughout meiosis. This work is divided into three work packages. WP1: to determine the molecular rearrangements that take place at telomeres during meiosis. WP2: to determine how and when telomeres are lengthened during germ cell production. WP3: to determine how meiotic recombination is achieved. The proposed project will reveal molecular mechanisms underlying the transgenerational inheritance of genetic information after meiosis, and this will increase our understanding of the etiology of numerous human diseases caused by meiotic errors, such as congenital birth defects and aneuploidy. Further, because the misregulation of telomerase is a leading cause of cancer development, the identification of telomerase-activating mechanisms in germ cells will have multidiscipline impacts in both cancer and reproductive biology fields and will be useful for developing novel cancer therapies.

Keywords: meiosis,homologous recombination,telomere
Earth Observation by Autonomous Solar UAV (SX1.3)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-02-03
End date: 2022-02-02
Duration (months): 24.0
Total project cost (EUR): 2663500.0
EU funding (EUR): 1864450.0
Participants: 1
Project status: CLOSED

XSUN develops an innovative autonomous solar drone dedicated to earth observation. Inspired from satellite earth observation, XSUN aims to offer affordable earth data acquisition performed by unmmaned autonomous vehicules to a range of end users which have all express their support to the SolarXOne project : Linear infrastructure observation (such as railway, pipeline or electrical grid), environmental & security surveillance issues (forest fire detection, traffic surveillance), Maritime observation (traffic surveillance, fishing surveillance), precision agriculture (monitoring of the health of crops and livestock). A first autonomous prototype is ready (TRL6). Thanks to a patented double-wing innovative design, the performances of SolarXOne are disruptive compared to existing solutions: large payload capacity (7kg) enabling to carry a wide range of data acquisition sensors, very stable flight enabling precise data acquisition, long flight (>600 km / Day), cheaper price for end user compared to competitors. A world record of autonomous solar flight will be tempted in the next months. SolarXOne project objectives are to industrialise the drone production with enhance performances. Adaptability to Hydrogen energy source will be added as well as vertical take-off capability. Market demonstration will be done during the project for linear infrastructure, fire detection, maritime surveillance and precision agriculture. Two operating centres will be opened in France and Germany. XSun is based on 2 complementary business models: earth data service commercialization operated from the control centres and complete system commercialization. Market analysis have been performed for each segment and the business plan shows promising revenue reaching 30 M€ in 2025. XSUN has been created in 2016, its team (12 people) is composed of experienced managers and business developers in the aerospace industry as well as young passionate engineers.

Keywords: solar autonomous drone,unmmaned autonomous vehicules,earth observation,maritime,surveillance,precision agriculture,linear infrastructure observation,beyond visual line of sight bvlos
Bioresin obtained from industrial tomato processing by-products (TOMAPAINT)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: Italy
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 2988055.0
EU funding (EUR): 2091638.5
Participants: 1
Project status: CLOSED

TomaPaint is an award winning green startup founded in March 2019 that has developed a high performance bioresin obtained from industrial tomato processing by-products. After positive experiments in the laboratory, and 10 years of research performed in the framework of 3 EU projects- FP7BIOCOPAC, LIFe BiocopacPlus and BBI-H2020 Agrimax- we have developed and validated a patented green process for the extraction of cutin from tomato peel, with good purity characteristics and high yield. Our market entry application is the use of the recovered cutin bioresin as the main component of a natural, safe and sustainable biolacquer for the coating of metal food cans as an ecological alternative to synthetic petrochemical-based lacquers, delivering significant environmental and health benefits. Our proprietary pilot plant is currently operational with a capacity of 12 tons/annum, batch production. This facility has been fundamental for R&D purposes for establishing the extraction process, modifying and optimising it. To meet market demand, we now need to scale to an industrial plant and to steadily increase annual capacity to produce 50 t/yr by 2021, 100t/yr by 2022, 200t/yr by 2023, eventually reaching full capacity, estimated at 500 t/yr. Thanks to the milestones we will reach through the EIC Accelerator, our target is to grow the business to €19.25M annual revenue through the sale of the bioresin for different high value applications as well as through licensing agreements for plants internationally that will secure long-term growth impacts. Tomapaint is a high-impact market creating innovation that will contribute to the EU’s Green Deal: The sustained Circular Value chains that will flourish around each plant will have a multi-million-euro impact on the local economies, with new job creation, reduced carbon emissions and wastes and increased resource efficiency and a model that is based on a self-regenerating economic system.

Keywords: cutin,bioresin,extraction from tomato by products,circular economy,bioeconomy,biolaquer,metal food cans,green deal,sdgs
Telehealth-ready AI-powered multi-parametric system for surveillance of COVID-19 and cardio-pulmonary chronic patients (PyXy.AI)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Action type: Innovation actions
Countries involved: Germany,Germany,Israel,Germany,Norway,Norway
Call: Medical technologies, Digital tools and Artificial Intelligence (AI) analytics to improve surveillance and care at high Technology Readiness Levels (TRL) (H2020-SC1-PHE-CORONAVIRUS-2020-2-CNECT, 2020)
Start date: 2020-12-01
End date: 2023-01-31
Duration (months): 26.0
Total project cost (EUR): 6782267.85
EU funding (EUR): 4863275.0
Participants: 7
Project status: SIGNED

The COVID-19 outbreak causes world health care systems to crumble under the load. This consortium proposes a Home-use/Point-of-Care device, incorporating improved clinical parameters, providing early detection, and monitoring of COVID-19 patients. This consortium presents a computerized auscultation device – the PyXy – which provides expert-level lung and heart check-up. The PyXy brings breakthrough capabilities in terms of sound and infrasound analysis, body temperature, blood oxygen levels, heart rate and respiratory cycle, all analyzed by artificial intelligence (AI) for accurate diagnostic data. The device recently showed very promising results in relation to managing COVID-19 disease. Using H2020 funds, the consortium plans to introduce the PyXy to the market within 22 months: allowing anyone to perform diagnostic at an accuracy not normally accessible to the medical staff. In this project the consortium will collect COVID-19 patient data and take the PyXy to high volume manufacturing level. The consortium gathers two technology provider SMEs – Sanolla, the developer of the PyXy device, and Medsensio, experts in AI for classification – together with an established player in the medical devices and e-health solutions – Riester. The work will be done in collaboration with four healthcare service providers (Natali, BeneVit, Helgeland and PhilonMed) to ensure the PyXy will be accepted by the market from all possible aspects. We believe that PyXy is capable to substantially reduce the health-economic impact on healthcare and elderly care services by preventing hospitalization in emergent-care situations. In addition, as PyXy can be used by lesser skilled individuals, we believe it will potentially bridge the gap in care settings that face extreme shortage of skilled workers, and can even be used by informal caregivers at home reducing the overall hospitalization rate even further.

Keywords: telehealth,auscultation