Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Investigating how anaphase chromosomal motion is generated during mitosis and meiosis (ChromoDrive)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 148635.6
EU funding (EUR): 148635.6
Participants: 1
Project status: CLOSED

Cell division is a process essential for life. There are two types of cell division: meiosis and mitosis. Meiosis is a type of cell division specific to germ cells, allowing the formation of fertilisation-competent sperm and eggs. Mitosis allows a single-celled fertilised egg to develop into a mature organism, and also allows tissues to be renewed. During each cell division, the cell must divide two copies of the genome equally between two daughter cells. Errors that occur during this process in oocytes can lead to spontaneous abortion and birth defects, whilst errors occurring in somatic cells can lead to genetic instability, a hallmark of cancer. It is therefore essential to understand how this fundamental process occurs. The phase of cell division during which the chromosomes are physically separated is called anaphase. Although anaphase has been studied for more than a century, the mechanisms that underlie the poleward movement of chromosomes in mammals are still unclear. Several studies have suggested candidate proteins that may power their movement, but there were no conclusive results due to the technically challenging nature of this research. The main challenge is that one must efficiently inactivate the candidate protein(s) only at the onset of anaphase so as to avoid disrupting the previous phases of cell division, which could confound the results. Methods to rapidly inactivate proteins targets have only recently become available. Here, we propose to use these techniques to study the mechanism(s) underlying poleward chromosome movement during anaphase in both meiosis (mouse oocytes) and mitosis (non-transformed mammalian somatic cells). In both cases, we will validate the results using a combination of loss-of-function and optogenetics tools, high-resolution live-cell microscopy, and laser microsurgery. This work will shed light on a fundamental biological process with obvious clinical implications for diseases such as cancer and reproductive disorders.

Keywords: mitosis,meiosis,anaphase,microtubules,molecular motors,chromosomes,kinetochores,cell division,cell cycle
Elucidation of intratumoral heterogeneity in Kras-driven cancers (INTUMORX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Finland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-07-01
End date: 2022-06-30
Duration (months): 60.0
Total project cost (EUR): 1972905.0
EU funding (EUR): 1972905.0
Participants: 1
Project status: CLOSED

The considerable variability within tissue microenvironments as well as the multiclonality of cancers leads to intratumoral heterogeneity. This increases the probablility of cellular states that promote resistance to therapy and eventually lead to reconstitution of the tumor by treatment-resistant cancer cells, which in some cases have properties of normal tissue stem cells. Wnt signals are important in the maintenance of stem cells in various epithelial tissues, including in lung development and regeneration. We hypothesized that Wnt signals contribute to tumor heterogeneity in genetically engineered KrasG12D; Tp53Δ/Δ (”KP”) mouse lung adenocarcinomas (LUAD). We observed that a subpopulation of LUAD cells exhibited high Wnt reporter activity and had increased tumor forming ability, which could be suppressed by silencing of Wnt signaling pathway components or by small molecule Wnt inhibitors in vitro and in vivo. KP LUAD cells show hierarchical features with two distinct populations, one with increased Wnt reporter activity and another forming a niche that provides the Wnt signal. Lineage-tracing experiments in the autochthonous KP tumors demonstrated that Wnt responder cells have increased tumor propagation ability in vivo. Strikingly, selective ablation of the Wnt responder cells resulted in tumor stasis. CRISPR-based targeting or small molecules targeting Wnt signaling reduced tumor growth and prolonged survival in the autochthonous KP mouse lung cancer model. These results indicate that maintenance of heterogeneity within tumors may be advantageous for the tumor cell population collectively. We propose to elucidate the molecular and cellullar mechanisms that control stem-like and niche cell phenotypes using a combination of novel lentiviral vectors and genetically modified mice in the context of the KP LUAD model. These efforts may lead to novel therapeutic concepts in human lung cancer.

Keywords: lgr5,kras,lung cancer,cancer stem cell,cancer heterogeneity
Electronic security for OIL/LPG tanks (E-LOCKS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Israel
Call: Critical infrastructure protection topic 7: SME instrument topic: “Protection of Urban soft targets and urban critical infrastructures” (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The demand of oil and gas including Liquefied Petroleum Gases (LPG) amounts to 766 million m3 in Europe, at a compound annual growth rate (CAGR) of 5.25% for the period 2009-2013. Currently, distributors and governments are suffering important financial losses due to theft, smuggling, and fraud in the delivery and sale of oil and gas products, costing European companies an estimated range from 100€ million to 1,300€ million every year. In WACnGO, our activity started in 2008 with the development of a powerful system to provide an integral logistics management solution to the liquefied petroleum gases (LPG) and oil distribution companies, based on software (SW) tools and hardware (HW) devices to control, maintain and optimize the logistics and operation of this industry. In WACnGO we are focusing on this market segment through the offering of innovative solutions and by being adaptive to customer needs. As one of the major issues to be tackled by oil/gas distribution companies is the prevention of the theft and fraud associated with the distribution of their products. We propose to prevent illegal practices and their direct economic consequences with an innovative security solution for oil/LPG tanks: the e-LockS solution. It is an integrated SW and HW architecture system based on two main components: - Caplock®: cap with the electronic lock integrated to be installed in each tank. - e-key®: intelligent key which will be managed from the Oil/LPG distribution management system (assignment of the permission to open a single tank and/or group of tanks).

Keywords: control software,security,protection of energy infrastructures logistics management,smart key,oil and gas
From Landscapes to Earthscapes: Understanding Visual Cultures of Global Environmental Crisis and the Making of Global Environmental Images, 1945-present (EARTHSCAPES) (EARTHSCAPES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

From Landscapes to Earthscapes: Understanding Visual Cultures of Global Environmental Crisis and the Making of Global Environmental Images, 1945-present (EARTHSCAPES) EARTHSCAPES will contribute to current debates on the origins and possible futures of the environmental crisis by providing an innovative historical, social and political perspective on the production, circulation and reception of global environmental images since the beginning of the Cold War. It will further our understanding of the role of images in science by means of a thorough historical, political and sociological analysis of case studies, focusing on visualisations that allow for a global interpretation and understanding of our environment (hence the term “global environmental images”). The images concerned by this project help communicate global and a priori invisible environmental phenomena (global temperature, ozone levels, sea-level rise, climate change, etc.). By making the invisible visible, global environmental images reveal to be always both, the very tools that enable scientists to understand complex environmental and geophysical processes, and the instruments that allow them to share their findings with decision makers and the larger public. Images fulfil therefore always two functions; they are both: objects and instruments of knowledge. Yet few studies have explored in detail this double function, allowing to understand how global environmental processes are visually produced, represented, rendered evident, and consumed. Hence, a historically informed interdisciplinary study is urgently needed, also because the past may hold crucial answers for the future. EARTHSCAPES main aim is to close the research gap by analysing how iconic paintings, photographs, maps, graphs, visualisations and remote sensing images profoundly shaped environmental discourse, and a holistic and dynamic understanding of the Earth system since the beginning of the Cold War.

Keywords: visual cultures of science,environmental history,scientific images
Physiological and Rehabilitation Outcomes: Gains from Automated Interventions in stroke Therapy (PRO GAIT) (PRO GAIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Italy,Italy,Austria,United States,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-03-01
End date: 2023-02-28
Duration (months): 60.0
Total project cost (EUR): 157500.0
EU funding (EUR): 144000.0
Participants: 7
Project status: CLOSED

Developments in robotics allow people with profound neuromuscular deficits after stroke to walk with assistance (during the gait cycle) using an exoskeleton robot. Integrating a robotic device with individualised user electroencephalography (EEG /electrical activity in the motor areas in the brain) and EMG (muscle)feedback would allow more physiological and targeted gait parameters in response to effort, and confer neuroplastic training effects including neuromodulation of temporal and spatial features of gait. Future integration of EEG/EMGsignals with robotic devices will allow patient initiated movement through thought and/or attempted effort, where currently parameters for devices are therapist set and usage is not functionally driven by the patient. Advancement in this regard is stalled primarily because of difficulty in 3D modelling of gait by EEG. This collaborative consortium through secondments and return and built in knowledge sharing strategies will exchange knowledge and expertise across: Design, development and production of exoskeleton gait devices; neuro-rehabilitation; bioelectric EEG/EMG signal capture and interpretation; mathematical modelling and brain computer interface (BCI) platform development can advance the state of the art in gait rehabilitation after stroke rehabilitation. The proposal will allow development of 3D modelling of gait, for gait restoration and explore integration with robotics from multi-stakeholder perspectives. Aims: 1. Define current state of the art in EEG modelling of gait post stroke by systematic review and meta-synthesis 2. Complete 3D modelling of gait as visualised gait, overground gait and robotic walking in healthy individuals and stroke survivors 3. Develop and test a virtual reality BCI gait training device, including end-user feedback 4. Explore integration of this prototype with robotic software platforms

Keywords: stroke,electroencephalography,electromyography,gait rehabilitation,exoskeleton robotics
Artificial intelligence design of molecular nano-magnets and molecular qubits (AI-DEMON)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Ireland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1499786.0
EU funding (EUR): 1499786.0
Participants: 1
Project status: SIGNED

As technologies based on semiconductors and ferromagnets are reaching their limits in computational and memory-storage capabilities, new technologies based on spin are emerging as alternative. Magnetic molecules represent the ultimate small-scale magnetic unit that can be synthesized and processed into a device for spintronics and quantum computing applications but their use is confined to very low temperatures. The grand challenge of this proposal is to design magnetic molecules with long spin lifetime at ambient temperature by tuning the main microscopic interaction responsible for spin relaxation: the spin-phonon coupling. AI-DEMON will address this challenge by developing a novel first-principles and machine-learning computational framework able to cover all the essential aspects of the design of new coordination compounds with tailored properties. AI-DEMON has three main objectives, each one representing a major contribution to the field: i) I will unveil the mechanism of spin-phonon relaxation in magnetic molecules by developing a quantitative first-principles spin relaxation theory, ii) I will efficiently explore the chemical space of magnetic coordination compounds by developing a universal machine-learning model able to predict vibrational and magnetic properties, and iii) I will design molecular prototypes with tailored magnetic and vibrational properties by developing generative machine-learning methods. Preliminary results on spin relaxation theory and machine-learning applied to magnetic properties show great promise and set the cornerstone of the project. The use of novel methodologies, such as machine learning and first-principles spin dynamics, represent a strong disruption in the current approach to theoretical modelling and discovery of new magnetic molecules and will propel the field into a new and modern era. Significant impact beyond the field of molecular magnetism, e.g. bio-inorganic chemistry and solid-state qubits, can also be anticipated.

Keywords: molecular magnetism,molecular qubits,spin phonon relaxation,spin dynamics,machine learning,first principles calculations
PeRsonnel lOcation and Tracking for safEty of Critical InfrasTructures (PROTECT-2)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Italy
Call: Critical infrastructure protection topic 7: SME instrument topic: Protection of Urban soft targets and critical infrastructures (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

A key enabling element to boost the Prevention, Preparedness and Consequence Management for the Critical Infrastructures (CI), including Urban Soft Targets, comes from the capability of pinpointing the location of the personnel operating in the frame of the Critical Infrastructure Protection. Although GPS positioning is a primary tool for localisation, nearly all CIs are GPS-denied/unreliable environments, as well as most urban soft targets. The impossibility of locating and tracking the operators in the scenarios where the GPS signal is absent (e.g. hostile jamming, indoor environments) is still a major cause of severe decrease of the Situational Awareness, thus degrading the prevention, preparedness and post-crisis recovery capabilities. Despite the global indoor location market is expected to grow to 4.424 million USD by 2019 (estimated Compound Annual Growth Rate (CAGR) of 36.5% from 2014 to 2019), there is still a substantial lack of products and solutions suitable for Critical Infrastructures Protection; indeed nearly all the current location systems (targeting to the mass-market of the Location Based Services) are heavily dependent on the infrastructures to be deployed and maintained in the operational environment: an approach hardly coping with the CIP requirements. In this landscape, DUNE plans to introduce in the CIP scenario a new personal, autonomous, infrastructure-free, wearable and scalable localisation and tracking system (e.g. inspectors, first responders, guardians, police) in GPS-denied environments, with a modular structure capable of fulfilling a widespread ensemble of requirements, typical of various CIP applications. By achieving the PROTECT project results, DUNE expects to boost its business and growth, with an estimated overall ROI of more than 300% and 500% in 3 and 5 years, respectively.

Keywords: localisation tracking gps firefighters indoor
SOCIAL ENERGY MARKET PLAYERS TO TACKLE ENERGY POVERTY (POWER UP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Spain,Italy,Italy,Italy,North Macedonia,Belgium,Belgium,France,Czechia,Netherlands,United Kingdom
Call: Mitigating household energy poverty (H2020-LC-SC3-EE-2020-2, 2020)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 1962832.5
EU funding (EUR): 1962832.5
Participants: 13
Project status: SIGNED

Regional and local public authorities have a strong role to play in fighting energy poverty. That is why the overall objective of POWER UP! is for cities to go beyond their planning role and sustain the creation of local energy market players with a social agenda. This will be realised by the following 3 specific objectives: - Implement pilot schemes for households in energy poverty, so that they benefit from renewable energy production and energy efficiency measures, without having to bear the financial risks; - Develop and reinforce local energy market players with a social agenda, based on a long-term perspective to acquire local knowledge and strengthen the local economy; - Disseminate the experience of the consortium members to facilitate the replication in European countries. Five pilot schemes will be developed in five locations across Europe: Eeklo (Belgium), Heerlen (the Netherlands), in the Campania area (Italy), in Rožnov pod Radhoštěm (Czech Republic), and Valencia (Spain). These schemes will be co-created with energy-poor households and local stakeholders (cities, social organisations, energy utilities, citizen energy communities etc.), leading to at least 2,5 Million EUR investment in sustainable energy before the project ends and involving 55 838 energy poor consumers. Supported by a European city network, a leading UK university, a Belgium cooperative and finance experts, the consortium will build the capacity of more than 185 people in local organisations. This will allow these players to either provide cheap energy to fuel poor households, or reinvesting benefits to carry out energy poverty mitigation measures.

Keywords: energy poverty,vulnerable households renewable energy,energy communities,energy efficiency,local energy market players,collaborative decision making,behaviour change,financial schemes
CHARge transport in Intermediate-Sized Molecules on Attosecond time scales (CHARISMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The CHARISMA project will investigate ultrafast charge transport induced by photoionization in intermediate-sized molecules. Charge migration is mediated purely by electronic dynamics on time scales down to hundreds of attoseconds. The subsequent interplay with nuclear dynamics on the femtosecond time scale can lead to charge transfer and localization. These ultrafast mechanisms play important roles in the interaction of ionizing radiation with biologically-relevant molecules, in molecular electronics, and also in astrochemistry. To gain fundamental insights into ultrafast charge transport it is necessary to study it in smaller molecules that are more tractable for experimental and theoretical methods. Such studies hold the promise to direct charge migration for controlling chemical reactivity, which would impact many chemical disciplines. Numerous theoretical studies have already addressed charge migration, but only recently advances in high-harmonic generation (HHG) sources, providing intense, ultrashort XUV pulses have made ‘real time’ experiments possible. It is therefore timely to study ultrafast charge transport in intermediate-sized molecules. These results will stimulate ongoing technical developments to extend the techniques to complex molecules of practical relevance in the near future. In pursuing this goal, CHARISMA relies also on coincidence experiments using synchrotron radiation to facilitate the challenging choices of meaningful experimental observables for the time-resolved studies. The researcher’s large experience in molecular photoionization using a variety of advanced light sources will be extended in this project, for which the state-of-the-art ultrafast lasers at Politecnico di Milano provide the perfect environment. CHARISMA integrates perfectly into the vibrant community of attosecond science in Europe and will demonstrate the synergy of synchrotron and HHG radiation in the pursuit of molecular control through ultrafast charge migration.

Keywords: attosecond science,charge migration,high order harmonic generation,synchrotron radiation,photoionization