Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Biocentric Ethic of Sustainable Agriculture (BIOTA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-09-01
End date: 2031-08-31
Duration (months): 60.0
Total project cost (EUR): 1499830.0
EU funding (EUR): 1499830.0
Participants: 1
Project status: SIGNED

BIOTA will develop a biocentric ethic of sustainable agriculture to address the lack of biocentric theorising in agricultural ethics and thereby promises to create a new sub-field in environmental philosophy. This necessary theoretical innovation will provide appropriate normative guidance for agricultural practices by reflecting on the plurality of different nonhuman lifeforms that are either the objects – like plants – or enablers – like soil microbes – of agricultural activities. Therefore, BIOTA pays particular attention to the often-overlooked non-sentient organisms facilitating agricultural practices, with a specific focus on plant agriculture (grain, vegetable and fruit farming) – which is frequently attributed a key role in sustainability transitions. Three interlinked layers (representing three objectives) form the core of BIOTA and – ideally – of any adequate biocentric agricultural ethic: (1) Biocentric theories argue that all living beings (incl. non-sentient organisms) are morally considerable. BIOTA will improve existing biocentric accounts by rethinking their main premisses in a more nuanced and relational way. (2) By developing agricultural ethics from a biocentric perspective, BIOTA will not only consider the farmer as a moral agent but put myriads of life forms that make agricultural practices possible into the centre of moral theorising (plants, the soil biota incl. bacteria, fungi and insects). (3) By theorising biocentrism in an empirically informed manner, BIOTA will develop its agricultural ethic in a way that reflects on environmental and technological change. That entails introducing systemic aspects beyond the typical scope of biocentrism – by reflecting on sustainability and socio-ecological resilience –, theorising on novel biotechnologies, and interviewing plant farmers themselves.

Keywords: ethics meta ethics,normative ethics,empirical ethics,biocentrism,plant agriculture,analytical moral philosophy,plants,insects,fungi,bacteria,farmer,relationality,environmental change,plant biotechnology
Signal to Regeneration (SigReg)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-03-01
End date: 2031-02-28
Duration (months): 60.0
Total project cost (EUR): 1834883.0
EU funding (EUR): 1834883.0
Participants: 1
Project status: SIGNED

One of the enduring questions in biology is understanding why mammals, unlike amphibians, are unable to regenerate their limbs. Recently, our knowledge of this fascinating and clinically relevant topic has evolved from tissue-level observations in amphibians to comprehensive cellular characterizations. My research was among the first to uncover the cellular composition of regeneration using single-cell RNA sequencing (scRNA-Seq), revealing the critical mechanisms of regenerative epithelial signaling center cell types (Aztekin et al., 2019, 2021). Building on this, my lab has established the equivalence of these cell types across species, including mammals (Zhong et al., 2023). Concurrently, we have developed novel, simplified models to probe their properties in detail (Aztekin et al., 2021; Skoufa et al., 2024). The overarching goal of "Signal to Regeneration" (SigReg) is to determine the potential of mammalian regeneration by dissecting the properties of regenerative signaling center cell types. For this, we will employ our mammalian stem cell protocols, skin cultures, and adult mouse amputation models in combination with imaging and sequencing. SigReg will elucidate: (1) how signaling centers quantitatively and dynamically interact with other populations, (2) which environmental factors shape the epigenetic landscape to form regenerative signaling centers in adult mouse skin, and (3) whether grafting signaling center cells can induce regeneration programs following mouse digit amputations. SigReg will establish the quantitative features of signaling centers while demonstrating the critical role of environmental and biomechanical factors in shaping a regenerative histone landscape in adult mice. By applying insights from amphibian studies to mammals, our findings have the potential to pave the way for inducing mammalian digit regeneration, potentially revolutionizing our understanding of regeneration and fueling research and the broader field for decades to come.

Keywords: limb regeneration,signaling centers,mouse digit tip regeneration,morphogen gradients
Philosophical Recommendations at Central European Arts Faculties in the Late-Middle Ages (PRAISE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-12-01
End date: 2027-11-30
Duration (months): 24.0
Total project cost (EUR): 207758.16
EU funding (EUR): 207758.16
Participants: 1
Project status: SIGNED

“Philosophical Recommendations at Central European Arts Faculties in the Late-Middle Ages” (PRAISE) offers a new perspective for emerging of the profound connections between the extant teaching practices and the transmission of philosophical ideas in Late-medieval Faculties of Arts. The focus of this project is the “recommendations” – these are celebratory speeches that were delivered by university masters on official occasions and include praise of individuals, such as students graduating from the Faculty of Arts, or of academic subjects, like Philosophy or Theology. Although “recommendations” were a commonly practice in Late-Medieval universities, their significance has, thus far, been overlooked by scholars. This research project will fill this gap, mapping out the “recommendations” made at the Faculties of Arts in Prague, Heidelberg, Cologne, Erfurt, Krakow and Vienna (founded within a few years of each other in the late-14th century, these universities share significant similarities in their statutes), with the aim of permitting clearer definition of this “new” genre. Furthermore, certain selected “recommendations” also include references to philosophy, philosophers or philosophical doctrines to be studied, which reveal perspectives on the teaching of philosophy as part of the Arts at the time. The project requires a candidate who combines skills in Palaeography and Philology, with knowledge of the Intellectual history of the Universities and the History of philosophy. The project will be supervised by Dr. Ota Pavlíček at the Institute of Philosophy of the Czech Academy of Sciences in Prague, and will feature training in intellectual history, as well as in digital humanities (Natural Language Processing). Two major papers will be completed, the first international conference on “recommendations” will be held in Prague, activity programs will be offered in a number of secondary educational high schools and an informative dedicated website will be created.

Keywords: intellectual history,history of ideas,history of philosophy,university speeches,the history of university study
Fifth Generation Technology Standard for European Union Governmental Satellite Communications (5G-GOVSATCOM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: EU Space
Destination: EU Space
Action type: Research and Innovation actions
Countries involved: Spain,France,Italy,Greece
Call: GOVSATCOM Service developments and demonstrations (HORIZON-EUSPA-2022-SPACE, 2022)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 1499812.5
EU funding (EUR): 1499812.5
Participants: 9
Project status: SIGNED

5G non-terrestrial networks (5G-NTN) satellite networks will soon be able to handle all types of applications and provide service to a massive number of users. In this complex and dynamic network ecosystem, and end-to-end adaptation of 5G-NTN towards the EU-GOVSATCOM services, requirements and use cases is of capital importance to efficiently deploy European governmental satellite services. To enable such a vision, 5G-GOVSATCOM targets the development and evaluation in a natural user environment of different key enabling technologies that aim to provide full integration of 5G-NTN in the EU-GOVSATCOM framework. In the radio technologies domain, 5G-GOVSATCOM targets the development of necessary adaptions and enhancements of radio access procedures to attend to geostationary mobile terminals in the exclusive governmental X-band. Furthermore, the integration of 5G-NTN user equipment with an antenna operationally focused on on-the-move and on-the-pause scenarios are planned. In parallel, in the inter-networking segments, 5G-GOVSATCOM aims to provide a seamless handover between terrestrial networks and NTN via a smart gateway while enhancing core-network functionalities. Finally, all project developments are planned to be first validated in a controlled lab with satellite connectivity and, posteriorly, experimentally tested in close collaboration with final users. These latter tests will constitute the first 5G-NTN trials with final users devoted to i) ubiquitous telemedicine in maritime areas and ii) crisis management connectivity bubble.

Keywords: 5g,terrestrial integration,governmental users,healthcare,crisis management,humanitarian aid
Extratropical-Tropical interAction: A unified view on the extratropical impact on the subtropics and tropics at weather timescales (ExTrA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Israel,Germany
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 1687470.0
EU funding (EUR): 1687470.0
Participants: 2
Project status: SIGNED

An immediate, critical challenge facing humanity is the impact of weather extremes under a changing climate across the globe. Accurate weather forecasts and reliable climate projections rely on understanding the complex interactions between the atmospheric circulation and the water cycle. Largely governed by deep clouds, tropical weather cannot be forecasted more than a day in advance, leaving almost half of humanity living in these regions even more vulnerable. Although extratropical (outside the tropics) flows can drastically affect tropical clouds and precipitation, this effect has not been systematically quantified or understood. The novelty of this proposal is in asking a new question: How do extratropical dynamics influence the (sub)tropics? We will build on our recent work and paradigm-challenging preliminary results to study how extratropical dry, cold air intrusions into the tropics dramatically modify its atmosphere and air-sea interaction. We will use a new global Lagrangian identification approach to study this extratropical-tropical interaction for the first time, and uniquely combine state-of-the-art data from multiple sources, diagnostic tools, and multi-scale modelling. We will quantify the global spatiotemporal occurrence, variability and trends of these events (WP1); understand their underlying dynamics and precursors in midlatitudes and their impact on the water cycle (WP2); and assess their suitability as predictors of high-impact tropical weather (WP3). A dedicated international observational flight campaign will allow us to synergistically study the extratropics’ impact on the tropics (WP4). Our findings will advance not only the meteorological community but also the oceanographic, cloud physics and climate dynamics scientific communities, by providing a unified, global view of the interacting large-scale atmospheric dynamics, clouds and precipitation through their common weather timescales, paving the way for timely, accurate weather warnings.

Keywords: midlatitude weather systems,rossby waves,air sea interaction,tropical extratropical interaction,high impact weather
Sustainable station-keeping systems for floating wind - Atlantic coast case study (TAILWIND-UP-HopOn)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Norway,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 32.0
Total project cost (EUR): 491985.0
EU funding (EUR): 491985.0
Participants: 2
Project status: CLOSED

TAILWIND-UP-HopOn will expand the existing knowledge on the design of station-keeping systems for floating wind energy on the Atlantic coast, making it publicly available to accelerate deployment. At present, only pilot projects have been implemented off the Portuguese coast, as large-scale infrastructures remain cost-prohibitive. Advancing knowledge to reassess and refine anchor system design methods and practices towards cost reduction is therefore critical. TAILWIND station-keeping technologies will be investigated with a focus on the specific conditions of the northern Portuguese Atlantic coast. The TAILWIND methodology will also be expanded by including different soil stress paths, scour analysis, and reliability studies. After the definition and characterization of the metocean and geotechnical scenarios including climate change, and the evaluation of the hydrodynamic response of selected technologies, TAILWIND-UP-HopOn will analyse the impact of vertical loads on the cyclic behaviour of soils subjected to multidirectional horizontal loading. The project will also assess whether scour and liquefaction of foundation soils, due to the vibration of mooring lines, significantly affect the performance of station-keeping systems for floating wind turbines. These inputs will be integrated into a numerical analysis of the soil-anchor system to identify new failure modes, reduce their associated risk, increase design reliability, and ultimately optimise its design. Integrating the data generated by the Hop On team with TAILWIND consortium outputs will contribute to the development of sustainable and efficient station-keeping systems for floating wind, tailored to the specific conditions of North Atlantic Coast. With this extension, the new TAILWIND project will impact the three main areas in Europe for offshore wind development: the North Sea, the Mediterranean Sea, and the Atlantic Ocean, while mobilising Portuguese excellence in a strategic area for the country.

Keywords: offshore metocean scenarios advanced triaxial tests multiaxial cyclic loads scour liquefaction hydrodynamics of offshore wind tecnologies cost effective mooring systems
Investigation into reasons for drinking among adolescents and young adults: a gender perspective. (OH-GENDER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-12
End date: 2026-02-11
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

In Europe, 53.5% of adolescents consume alcohol in excess, but what has attracted attention is the increase in consumption among girls. These used to drink less than boys, but now their consumption is equal and on some contexts larger than boys. How this happens in Europe, where it can be considered a trendsetter, should be a global concern. Thus, understanding the reasons for this behavior change is essential to develop prevention program strategies that are effective in young people. Existing programs are not successful, they do not focus on specific gender situations and also on the mechanisms involved in this process. In addition, studies to date do not have a quantitative assessment, as there are no instruments to unravel the reasons for alcohol consumption from the perspective of gender difference. Current studies have only a qualitative assessment, it is impossible to compare groups of people and populations, making a global view of this field unfeasible.Thus, the proposal will unravel the determinants of alcohol consumption in adolescents and young adults from a gender perspective. This will be a paradigm shift in the knowledge of alcohol consumption. OH-GENDER is highly original and innovative as it provides a new instrument for quantitative assessment and will deliver a new model of consumption of alcohol determinants by an advanced technique of statistical analysis (Structural Equation Model) advancing the field of gender disparity. a tool to identify the different needs between girls and boys, disclosing the determinants of alcohol consumption from a gender perspective will be an advance in the state of the art, filling this unexplored knowledge gap. The proposal will advance in the field of alcohol consumption prevention and has the potential to be an ongoing study after PF.

Keywords: alcohol related disorders
Determining the mechanisms of lipid-targeting antibiotics in intact bacteria (champANTIBIOTICS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Antimicrobial resistance is a major threat to global health. To combat this threat, new antibiotics with novel binding modes are urgently needed. Ideal candidates could be lipid-targeting antibiotics (LT-antibiotics) that target special lipids that only exist in bacterial, but not in human cell membranes. These drugs kill refractory pathogens without detectable resistance. This has generated huge interest. So far, the molecular mechanisms of LT-antibiotics have proven elusive due to technical challenges: 1) structures of small drug?lipid complexes in membranes cannot be solved by traditional methods; 2) LT-antibiotics need to oligomerize to become active; and 3) binding modes are strongly affected by cell membrane profiles. In consequence, it has been impossible to visualize native binding modes and an entire class of potent antibiotics remains poorly understood. In pioneering studies on the drug teixobactin, my lab recently presented the first quantitative insights into the mechanisms of LT-antibiotics in cell membranes. Strikingly, we discovered that teixobactin uses a novel ?double attack? type of antimicrobial action, in which teixobactin forms large oligomers that both block the peptidoglycan synthesis and damage bacterial membranes. These findings raise new questions about LT-antibiotics. I propose to establish a comprehensive understanding of LT-antibiotics by elucidating their native binding modes in intact bacteria and at several length-scales (? to ?m). To this end, I will develop solid-state NMR methods, isotope-labelling strategies, and super-resolution microscopy setups. With these tools, I will elucidate the mechanisms of some of the most promising antibiotics of our time: 1) novel drugs from unculturable bacteria; and 2) daptomycin, a front-line drug whose mechanism has been chased by two generations of scientists. This research will outline groundbreaking strategies for determining antibiotic mechanisms and, in so doing, address a pressing

Keywords: molecular mechanisms of antibiotics solid state nmr in cell structural biology
Skin microbial metabolites and antimicrobial peptides at the interface of skin-gut inflammation (INTERACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-03-01
End date: 2026-08-31
Duration (months): 30.0
Total project cost (EUR): 225843.6
EU funding (EUR): 225843.6
Participants: 2
Project status: SIGNED

Skin diseases affect 900 million people worldwide. Despite major efforts gaining insights in the disease mechanisms underlying Atopic Dermatitis (AD), the most common inflammatory skin disease (ISD), an effective treatment is currently lacking. AD is accompanied by skin and gut microbiota dysbiosis, suggesting an uncharacterized interplay between skin and gut. Furthermore, antimicrobial peptides (AMPs) that limit growth of bacteria in the host, were found deregulated in ISDs and Inflammatory Bowel Disease. Most of the host-microbe interactions are mediated by microbial metabolites that can spread and affect distant organs. INTERACT will investigate how skin microbial metabolites influence skin and gut inflammation through innovative research at two world leading research Universities, the Medical University of Vienna, Austria and University of California San Diego, USA under the supervision of Profs. Erwin Wagner and Richard Gallo, respectively. Recent results from the applicant demonstrated gut alterations with neutrophilic infiltration and increased fecal AMPs in a genetically engineered mouse model (GEMM) of AD generated in E. Wagner’s laboratory. Hence, this study will test the hypothesis that skin-derived microbial metabolites promote skin-gut inflammation inducing AMP expression and neutrophil recruitment. Using state of the art technologies, such as metabolomics and novel GEMMs, as well as patient-derived material, this project will determine the therapeutic and biomarker potential of microbial metabolites, which will have profound implications for ISD. The experimental approach combines the applicant’s expertise in host-microbe interactions with E. Wagner´s competence in mouse genetics and inflammatory diseases, as well as R. Gallo´s knowledge of AMPs and skin microbiome. The MSCA PF will support the applicant´s career development by fostering acquisition of mechanistic and complementary skills, while studying a global health problem and economic challenge.

Keywords: inflammatory skin disease,atopic dermatitis,microbiome,metabolites,antimicrobial peptides,gut inflammation,s100a9,inflammatory bowel disease,genetically engineered mouse models