Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of non-toxic, low-cost, high-performing, disinfecting household gadget to prevent the spread of germs, viruses, bacteria, and fungus. (3E)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Germany,Norway,Netherlands
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2020)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 3886353.75
EU funding (EUR): 2720447.63
Participants: 3
Project status: CLOSED

The scientific term "hygiene" refers to the maintenance of health and healthy living. Our objective is to develop a low-cost household gadget (3E) that will generate an in-situ, ready-to-use, high performing, effective, and non-toxic disinfecting agent to reinforce the measures of keeping personal-hygiene at the highest level and helping in preventing the spread of diseases. 3E concept eliminates the need for using expensive, harsh, and toxic chemicals or alcohol-based personal disinfectant products. The gadget works only with tap water and table salt, Sodium chloride (NaCI), which can be found most probably in every house. The 3E gadget converts regular table salt and tap water into Neutral Electrolyzed Water to destroy infectious organisms. The electrolysis of salt produces a solution of hypochlorous acid (HOCI) and sodium hydroxide (NaOH). The resulting water can be used as a safe non-toxic disinfectant. The solution kills bacteria, microbes, and germs by 99,9%. The solution sterilizes, deodorizes, and purifies the air as well and is safe to use for delicate applications such as pets, kids’ toys, and food. 3E will sterilize and deodorize simply every surface and even clothes, carpets, furniture, and shoes. 3E gadget can be used at home, at the car, at the office, wherever sterilization and cleaning is needed. The expected outcomes of the project are increasing public health, reinforcing the prevention measures of the spread of germs, viruses, bacteria, and fungus, introducing a completely new, low-cost, safe household cleaning, a non-toxic disinfecting solution to end-users. Unlike conventional detergent and other disinfectant products, 3E solution can be used safely and easily on all surfaces, including food. The initial investment of buying the 3E gadget is returned in an average of 2 months and saves money throughout its lifetime.

Keywords: disinfecting,household gadget,non toxic disinfection,low cost cleaning,low carbon emission,fmcg,homecare products
A New Therapeutic Option to Protect Central Nervous System against Acute Ischemic Stroke (SYN1002)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: France
Call: Dedicated support to biotechnology SMEs closing the gap from lab to market (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2018-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Each year, about 16 million strokes occur in the world causing millions of deaths and one third of patients experiencing permanent disability. The main treatment of stroke is thrombolytic agent recombinant tissue plasminogen activator (rtPA). Not all the patient can qualify for this treatment and it can be administered only in a limited time window. No existing drug is approved to protect against ongoing neuronal damage after the acute event. In this framework, our company, ORPHIT, a seed-stage biotech company, intends to be a pioneer by bringing clinical proof of concept of our peptide SYN1002 as suitable neuroprotective anti-inflammatory agent to treat stoke in acute phase that could be administered at multiple doses as complement to current thrombolytic treatments and also in patients who do not qualify for treatment with rtPA. This peptide is our lead product and has been initially developed as a potent anti-inflammatory substance in auto-immune pathologies with a clinical phase 1 study successfully documenting the safety and tolerability. Its properties make it a perfect match with current needs on Stroke treatment. Therefore, our solution is of interest for the pharmaceutical industry and health institutes who are currently in the search of a treatment that would be efficient and safe enough to be applicable to a larger part of the persons suffering from Stroke. The acute ischemic stroke (AIS) therapeutic market generated 400M€ in 2012 across the six major markets and is expected to reach 1.1 billion € by the end of 2017. SYN1002 sales at peak (2026) are expected to achieve 50% of market share, and a licensing deal at end of phase IIa would come out with a net present value of 265M€ for our company. In order to achieve this goal ORPHIT will realize a feasibility study aiming at strengthening SYN1002 preclinical package in AIS indication, confirming drug positioning through in depth market study, and draw a European business plan.

Keywords: syn1002,stroke,neuroprotective,anti inflammatory,therapy
Joint Doctorate in Molecular Animal Nutrition (MANNA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Spain,Italy,Croatia,Slovakia,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2018-06-01
End date: 2022-11-30
Duration (months): 54.0
Total project cost (EUR): 2793778.56
EU funding (EUR): 2793778.56
Participants: 6
Project status: CLOSED

The European “Joint Doctorate in Molecular Animal Nutrition” – MANNA – includes 6 universities, 9 private companies and 3 public research institutes from 8 European countries. The goal is to: 1) develop an Elite European School to train early stage researchers (ESR) in OMIC technologies applied to animal nutrition and in essential scientific, entrepreneurial and management skills; 2) evaluate the influence of innovative feed additives on animal production; 3) deliver double doctoral (PhD) degrees in a multidisciplinary and multi-sectoral network to develop a generation of internationally equipped scientists for the global workplace. The objectives will be achieved by co-supervising each of 11 ESRs with two Beneficiary Universities and a non-academic participant. They will work on integrated innovative research projects, designed to investigate the effects of anti-oxidants, microRNA, exosomes, methionine, lipids and plant derived anti-inflammatories in livestock diets on growth, intestinal health and systemic metabolism which will be assessed by integrating transcriptomic, microbiomic, proteomic and metabolomic approaches in both in vivo and in vitro models. The results will go into informatic platforms to build analytic systems based on IBM-Watson cognitive computing. Secondments will enhance the research programmes of all ESR being based in industry and non-academic research institutes, whose field of activity include animal nutrition, veterinary diagnostic and clinical research, bioinformatics and professional communication in the agro-food sector. All will contribute to training by including ESR in their working team, and providing lectures and training sessions in Summer Schools and workshops which will reinforce the graduate programmes of each University. The joint governance structure of MANNA will manage the recruitment, supervision and assessment processes across the network and will become embedded in the future post graduate education of each University.

Keywords: livestock,biomarkers,omics,anti oxidants,anti inflammatory,bioinformatics
Elucidating novel post-transcriptional regulatory mechanisms in neural development (Brain_stability)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

During brain development, neural stem cells (neuroblasts) divide asymmetrically to produce a neuroblast and a neural progenitor cell, the ganglion mother cell (GMC), which will later divide to produce two neurons or glia. Asymmetric protein localization and transcriptional activation are two well-established mechanisms that influence cell fate decisions during this process. I hypothesize that a relatively unexplored regulatory component—mRNA stability—also plays a major role in neural differentiation. mRNA stability is regulated to achieve high temporal and spatial control of gene expression and may therefore provide a powerful way to establish or reinforce cell fate decisions in the nervous system. However, little is known about the functions of regulated mRNA stabilization or decay during development of the brain (or any other complex tissue). Our lab recently discovered that the mRNA encoding a key conserved neural differentiation-promoting transcription factor, Prospero, is unstable in Drosophila neuroblasts, but is stabilized in the more differentiated GMCs. This proposal seeks to expand upon this finding and to determine the extent of mRNA stability regulation and its functional significance in the developing brain. I aim to develop a novel genome-wide technique that will allow quantitative comparison of mRNA decay rates between neuroblasts and GMCs. I will then use this technique to query the function of conserved RNA-binding proteins in the regulation of neural mRNA stability. Finally, I will use our state-of-the-art live brain imaging assays to determine the functional requirement for specific regulatory events in brain development at the cellular and molecular levels. The experiments described in this proposal have the potential to uncover a major new class of post-transcriptional regulatory events that determine the balance between proliferation and differentiation in the developing brain.

Keywords: mrna stability and decay,brain development,neuroblast,live cell imaging,drosophila melanogaster
Devising certifiable and explainable algorithms for verification and planning in cyber-physical systems (ALGOCERT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Israel
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-15
End date: 2021-07-14
Duration (months): 24.0
Total project cost (EUR): 185464.32
EU funding (EUR): 185464.32
Participants: 2
Project status: CLOSED

One of the main challenges in the development of complex computerized systems lies in verification -– the process of ensuring the systems' correctness. Model checking is an approach for system verification in which one uses mathematical reasoning to conduct an algorithmic analysis of the possible computations of the system, in order to formally prove that a system satisfies a given specification. Traditionally, model checking is done as follows. The user inputs a system and a specification to a model checker, and gets a yes/no output as to whether the system satisfies the specification. Typically, when the answer is ``no'', a counterexample is also outputted, usually in the form of a computation of the system that violates the specification. This gives the user an informative output that can be used to fix the system, or, possible, the specification. A drawback of model checking is that, in contrast with providing counterexamples for ``no'' answers, a ``yes'' answer does not include any proof, explanation, or certificate of correctness. The advantage of having such certificates is twofold: first, it would help convincing the designer of the system's correctness, and second, it can be used to gain insight into the workings of complex systems. A similar drawback occurs in an application of model-checking to robotic planning. There, a suggested plan issued by the model checker may seem complicated or counter intuitive to a human user. Thus, one would want some explanation of the plan, that would convince the user of its correctness, and, possibly, its optimality. The aim of this proposal is to address the challenge of providing certificates for the correctness of systems, and analogously -- providing explanations for plans. This involves several challenges: finding contexts in which explanations and certificates have reasonable definitions, and then - devising a suitable theoretical algorithmic framework, and a practical, scalable implementation.

Keywords: verification,planning,model checking,dynamical systems,automata,synthesis,invariants
Material damage and buckling instability: towards a unifying general theory (DamBuckler)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

General structural stability theories have been hitherto restricted to elastic systems. This constitutes a significant weakness in current structural stability analysis techniques particularly owing to the increasing use of composite structures in lightweight construction. The DamBuckler project aims for this to be resolved by developing a novel generalized theory that unifies the concepts of structural stability and material damage. Hence, a novel variational principle will be developed that is capable of determining the deformation path, its stability and the damage growth behaviour of mechanical systems. The variational principle will be based on an energy functional, depending on the configuration only, which will be derived by analysing the behaviour of the energies related to elastic and inelastic deformation with respect to variations of the damage state. With the aid of the novel general structural stability theory, the effect of material damage and its propagation will be considered and analysed in the stability analysis of structures. The theory will be applied to an application example which is particularly relevant for aircraft structures: the modelling of the compressive behaviour of composite panels with barely visible impact damage. Hitherto, detailed mechanical insight into the structural stability behaviour of these structures is restricted since analytical models are confined to non-growing damage. Moreover, comprehensive finite element models, although consider damage growth, are related to certain structural configurations and damage locations. The novel general theory will enable the formulation of semi-analytical modelling approaches that will provide insight into the influence on the structural stability from varying material parameters, laminate layup, layer thickness, delamination depth and geometry, alongside the effect of multiple and distinct damage parameters such that they can be understood comprehensively and predicted with accuracy.

Keywords: structural stability,damage growth,general theory,composite structures,nonlinear buckling,barely visible impact damage
Tyre Impact on Optimized Composite Wing panel (TIOC-Wing)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Belgium,France
Call: Development of a methodology to optimize a wing composite panel with respect to tyre damage certification requirement (H2020-CS2-CFP10-2019-01, 2019)
Start date: 2020-07-01
End date: 2022-11-30
Duration (months): 29.0
Total project cost (EUR): 1511775.0
EU funding (EUR): 1511775.0
Participants: 3
Project status: CLOSED

Thanks to the confidence gained in the numerical simulation methods through correlation with a wide range of tests, nonlinear “realistic simulations” are taking more and more place in the design and sizing of aeronautical components during development and Certification phases. Airworthiness Authorities agree more and more to use the “virtual testing” or “realistic simulations” as means of compliance for all the items for which an acceptable level of validation of methodologies has been demonstrated. The main objective of the TIOC-Wing project is the development and the validation of criteria and a virtual testing methodology that will allow to predict the resistance of a representative stiffened composite wing panel subjected to the impact of tyre debris and the residual strength capability of the damaged structure. This will be reached by means of a test program focused on tyre debris impact events on composite aircraft structures and using the acquired experimental data to develop and validate numerical computational tools. The Consortium of TIOC-Wing project joins expertise in composite material knowledge, testing and manufacturing, in tyre tread impact testing and numerical simulations from 3 partners: SONACA, DGA-TA and CENAERO coming from Aeronautical Industry, referenced Test Laboratory in foreign objects impact capabilities and Research and Technology Center in advanced numerical simulations. TIOC-Wing will give the opportunity for the partners of the Consortium to enhance the level of expertise in the field of foreign objects impact aircraft vulnerability. For the industrial partners, the anticipation of such particular risks in the early stage of the development of an aircraft will reduce inherent costs due to possible modifications in a more advanced phase of the program, needed to satisfy the Certification requirements. This also enables to increase the competitiveness through innovation by integration of advanced computational tools in the sizing loop. Decrease of development tests will have as consequence the decrease of non recurrent costs. Finally, during future development of the next generation of aircraft thanks to less conservative approaches, TIOC-Wing offers the means for possible optimization of design concepts and weight savings strategies with reducing the CO2 emissions.

Keywords: virtual testing,tyre debris impact,composite materials,damage,failure,advanced numerical simulations,residual strength capability
PLUG-AND-USE RENOVATION WITH ADAPTABLE LIGHTWEIGHT SYSTEMS (PLURAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies enabling energy-efficient systems and energy-efficient buildings with a low environmental impact
Action type: Innovation actions
Countries involved: Spain,Germany,Italy,Switzerland,Greece,Greece,Poland,Greece,Czechia,Czechia,Czechia,Czechia,Czechia,Luxembourg
Call: Industrialisation of building envelope kits for the renovation market (IA) (H2020-NMBP-ST-IND-2020-singlestage, 2020)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 9663495.03
EU funding (EUR): 7973817.7
Participants: 20
Project status: SIGNED

PLURAL aims to design validate and demonstrate a palette of versatile, adaptable, scalable, off-site prefabricated plug and play facades accounting for user needs (“Plug-and-Use” kits). Three different core systems are assessed, coupling heating-cooling, ventilation, heat harvesting systems with smart windows, 3D printing, low carbon footprint and nano-enabled coating materials to reduce the building total primary energy consumption to less than 60 kWh/m2 per year and ensure on-site renewable energy generation to more than 50 kWh/m2 reaching NZEB status for different European climates and different residential building typologies. A BIM based big data management platform and a Decision Support Tool (DST) are coupled to enable the optimal component selection, and integration, best PnU kit design, speedy and low-cost manufacturing and installation. Renewable energy and smart control systems are coupled with low environmental footprint prefabricated façade components to create the integrated all-in-one PnU kits for post war residential building deep renovation. The project creates best practice renovation examples for the residential sector based on innovation and competitiveness, with benefits for the citizens and the environment. It develops business cases and models for key stakeholders and improves the life cycle based performance standards applied in the building sector. The solutions are implemented in three real and three virtual residential buildings to evaluate reduction in renovation time and costs, the PnU kit performance, carbon saving and users’ acceptance. The selected buildings cover all European climatic zones and are representative residential typologies. PLURAL will achieve at least 50% reduction in the time required for deep renovation of e.g. multi-family blocks. 58% reduction in renovation costs will be achieved through off-site prefabrication lean manufacturing and construction, interactively supported by the BIM based platform and DST.

Keywords: off site prefabrication,nzeb,renewable energy systems,adaptive control,it based predictive monitoring,decision support tool,low co2 signature materials,digital manufacturing,3d printing