Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Supramolecular Approach to Schwarzite Carbon Materials (SCHWARZITE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Considerable progress has been made over the past thirty years in the synthesis and preparation of 0D, 1D, and 2D sp2-hybridized carbon materials, as well as for their smaller discrete nanosized polycyclic aromatic hydrocarbon (PAH) counterparts. However, 3D sp2-hybridized carbon networks, called schwarzite carbons or Mackay-Terrones crystals – first proposed in the early 1990s – remain elusive, despite exciting electronic properties and important applications being predicted for these porous crystalline all-carbon solids by theoreticians. Little activity has been devoted to this new class of carbon materials due to the enormous challenges foreseen for their synthesis. Even research towards 7- and 8-membered rings, whose saddle-shaped structures are the prerequisite for schwarzite-type molecular carbon materials, has only recently become a research focus for a still small number of chemists. Based on an efficient synthetic method for heptagon-containing PAHs recently developed by our laboratory and the subsequent demonstration of the perfect schwarzite-like organization of four of such molecules around a C60-fullerene template, we herein propose rational strategies for both schwarzite-inspired saddle-shaped nanostructures as well as 3D schwarzite-like porous pi-conjugated solid-state materials. Thus, in this project, novel saddle-shaped PAHs bearing schwarzite-inspired sequences of hexagons and heptagons will be synthesized and self-assembled around fullerenes and other spherical template molecules, and characterized by supramolecular binding studies and single-crystal X-ray diffraction. Various synthetic approaches will be pursued for the post-functionalization of these complexes to afford pi-conjugated cage molecules and schwarzite-type pi-conjugated 3D materials. The functional properties of these novel materials will be explored with a broad repertoire of available techniques in our laboratory.

Keywords: organic materials,organic electronics
Making Time: Organized Labour and the Politics of Care Leave (MakingTime)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-08-01
End date: 2030-07-31
Duration (months): 60.0
Total project cost (EUR): 1494433.0
EU funding (EUR): 1494433.0
Participants: 1
Project status: SIGNED

Promoting work-life balance has been a focus of recent directives from the European Commission and a source of policy innovation in several countries. Social policies that make time for family and self-care are important tools for building sustainable work, but countries vary considerably in the extent to which such tools are available. Trade union organizations may play an important role for developing statutory care-related leave rights and protections, particularly as women still provide a bulk of family caregiving and now constitute a majority or near-majority of union members in many countries. This project will use a novel mixed-method design to investigate organized labour’s relationships to national leave policies that grant time-off from work to address care needs, including leave to care for a child, aging parent, or ill spouse or to address self-care needs through sick leave or disability benefits. Quantitative analyses will examine union-policy relationships across rich democracies starting in 1965, and qualitative analyses will examine organized labour’s policy advocacy in Ireland, France and the Netherlands. Analyses of predictors will distinguish between different types of social provisions, consider differences in trade unions and the types of workers they represent, investigate the mechanisms of potential union influence over policy, and compare union-policy relationships across different institutional contexts. A central ambition is to integrate the interdisciplinary fields of comparative policy analysis and social movement research to advance comparative labour studies and develop new theories of union-policy relationships. The project will additionally develop data infrastructures, offering much-needed longitudinal, comparative data on different types of care leave provisions. Overall, the project will assess the extent to which organized labour can be a partner for developing social policies that promote sustainable work for the future.

Keywords: comparative policy analysis,mixed methods,political sociology,social movements,social policy,trade unions
MYokinetic Towards Innovation (MYTI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-05-01
End date: 2025-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

MYTI - MYokinetic Towards Innovation, aims at boosting the clinical translation of the technology developed within the ERC funded project MYKI - A Bidirectional MyoKinetic Implanted Interface for Natural Control of Artificial Limbs. Core of the project is an innovative human-machine-interface for the control of upper-limb prostheses, which relies on a multitude of permanent magnets implanted within the residual muscles. Briefly, external electronic components acquire the magnetic field of the magnets, retrieve their displacement resulting from muscle contraction, and subsequently decode the user’s intention to control multiple degrees of freedom of the prosthesis in a natural and intuitive way. The MYKI project led to the successful first-in-human clinical demonstration of the interface: one participant received the short-term (six-week) implantation of multiple magnets and was fitted with a self-contained myokinetic prosthesis. In just six weeks, the participant achieved performance comparable to those achieved with standard-of-care solutions. Building on the know-how acquired within MYKI, MYTI will address the weaknesses uncovered by past research, and push forward the advancement of the solution for its adoption into standard-of-care settings. Practically, it will address the open challenges related to the long-term usability of the interface, to enable extensive long-term clinical trials necessary to validate the technology, while laying the foreground for its future commercialization. The translation from research towards innovation will be achieved through three main objectives: (i) the identification of a magnet coating material suitable for chronic applications; (ii) the effective insertion of the magnets inside the muscles, through the development of a dedicated surgical injector to be used under ultrasound guidance; (iii) the conduction of an in-depth market research and the definition of an IPR strategy aimed at the future technology commercialization.
Foundations of quantum computational advantage (FoQaCiA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Portugal,Sweden,Spain,Türkiye,Canada,United Kingdom,Poland,Germany
Call: International cooperation with Canada (RIA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-10-01
End date: 2026-03-31
Duration (months): 42.0
Total project cost (EUR): 1247340.0
EU funding (EUR): 1247340.0
Participants: 12
Project status: SIGNED

In FoQaCiA, we will expand the theoretical basis for the design of quantum algorithms. Our view is that the future success of quantum computing critically depends on advances at the most fundamental level, and that large-scale investments in quantum implementations will only pay off if they can draw on additional foundational insights and ideas. While several powerful quantum algorithms are known, the basic techniques they employ are few and far between. Largely, it still remains to be discovered how to systematically harness the quantum for computation. We study four areas of quantum phenomenology: (i) Quantum contextuality, non-classicality, and quantum advantage, (ii) Complexity of classical simulation of quantum computation, (iii) Arithmetic of quantum circuits, and (iv) Efficiency of fault-tolerant quantum computation. These fields are chosen for two reasons. First, their progress is of great importance for the physical realisation and the broad applicability of quantum computation. Regarding (i), one of the simplest proofs of quantum contextuality, Mermin’s star, has recently been employed to prove (Bravyi, Gosset, König) that bounded-depth quantum circuits are more powerful than their classical analogues. We seek to expand this result beyond bounded depth. In (ii), we study the quantum speedup by shaving off the redundant part – the efficiently classically simulable. In (iii), we aim to provide more efficient techniques for gate and circuit synthesis, utilising the number-theoretic underpinnings of the problem. Regarding (iv), given the celebrated threshold theorem, and the fact that the error threshold is now known to be within reach of experiment, we will tackle the remaining challenge of reducing the cost of fault tolerance. The second reason for selecting the above work areas is to mine them for foundational quantum mechanical structures and find related quantum algorithmic uses.

Keywords: quantum computing,contextuality,non locality,wigner functions,classical simulation,fault tolerance,magic state distillation,quantum cryptography,gate synthesis,number theory,topological methods
Parasite-host interactions regulating dormancy and reactivation of malaria parasites (Host4Hypnozoites)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC Synergy Grants (ERC-2023-SyG, 2023)
Start date: 2024-03-01
End date: 2030-02-28
Duration (months): 72.0
Total project cost (EUR): 12572460.0
EU funding (EUR): 11429675.0
Participants: 3
Project status: SIGNED

What? Hypnozoites are dormant liver stage malaria parasites that can reactivate and cause repeated blood-stage infections without the bite of an infectious mosquito. We will, for the first time: - characterize the cellular environment contributing to dormancy at systems level (WP1) - explore the reactivation kinetic and tissue environment of hypnozoites within the natural host (WP2) - functionally characterize host & parasite factors governing dormancy or reactivation (WP3) Why? - Dormancy and reactivation of hypnozoites is an unresolved biological mystery since decades - Dormant parasites are a major obstacle to the curative treatment of malaria The challenge: Tracking the in vivo development and understanding the biology of these rare, quiescent parasites that normally reside inside the liver of the host The solution: A synergistic, multidisciplinary investigation, which is only possible if we combine the unique resources and complementary expertise of three leading laboratories in: - Radiopharmaceutical chemistry for the development of dedicated Positron Emission Tomography tracers for non-invasive investigation of the parasites in situ, as well as to capture infected tissue samples for systems level investigations - Systems biology for simultaneous multi-omics profiling of the parasite and the host cell at single-cell resolution and in the spatial context to be validated by parasitological assays - Parasitology for functional investigation through genetic engineering and manipulation of the parasites in vitro and validation within the natural host Anticipated project outcomes: - Detailed insights into the relapse characteristics of the parasite in vivo - Understanding how host and parasite factors collectively determine the fate of infection - Novel imaging, transfection and omics methods for malaria research and beyond - Opportunities for novel therapeutic strategies for awakening and killing these vicious pathogens

Keywords: relapsing malaria,dormancy,in vivo imaging,host pathogen interaction,liver,radiopharmaceutical chemistry,genetic micro manipulation,multi omics,pet tracers,epigenetics,translational repression
Drivers of spatiotemporal variation in temperature-related morbidity and mortality in Europe: analysing early adaptation to climate change (TEMP-MOMO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-09-30
Duration (months): 25.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: CLOSED

Europe emerges as a major climate warming hotspot. The temperature rise in the region has occurred at a rate faster than any other continent in recent decades, with 2020 being the warmest year on record at more than 1.6°C above the period between 1981 and 2010. Such a change in temperature has serious implications for health, wellbeing and quality of life of the European populations, as warmer conditions are expected to contribute to an increase (decrease) in heat-related (cold-related) burden of disease (morbidity and mortality). However, there is still insufficient understanding of the impacts of climate change on human health throughout the European Union, particularly at local level, and this gap in knowledge continues to hinder adaptation efforts of the local and regional authorities (LRA). The purpose of TEMP-MOMO is to assess the recent evolution in morbidity and mortality risk and burden associated with ambient temperatures and its main demographic and socioeconomic drivers in France and Spain, using a multi-scale spatial analysis approach. Towards this aim, TEMP-MOMO will generate a massive database with daily counts of death and hospital admissions, together with the best available climate, demographic and socioeconomic datasets. The project will greatly contribute to the EU Mission on Adaptation to Climate Change by addressing knowledge gaps and providing customised data and tools that help decision makers to take informed decisions at all levels of governance from local to country level to protect human health. Specifically, by the end of the project all the local administrative units (LAU) and regions (NUTS) in France and Spain will have easy access to data and climate risk profiles through an interactive mapping tool, the “Temperature and Health Vulnerability Atlas”, to better prepare for climate change related shocks and disruptions.

Keywords: climate change,temperature,morbidity,mortality,adaptation,demographic and socioeconomic factors
Fourier decay for nonlinear fractal measures (FoDeNoF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Finland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 226276.8
EU funding (EUR): 226276.8
Participants: 1
Project status: SIGNED

This MSCA project studies the Fourier transform of dynamically defined fractal measures. Determining whether the Fourier transform decays to zero, and if so then at what rate, provides important information about the measure. There has been an explosion of interest in this topic in the past few years, spurred by a wealth of applications: Fourier decay is connected to a wide range of problems from harmonic analysis, Diophantine approximation, additive combinatorics, and quantum chaos. Up to now, most of the literature has focused on the Fourier decay of self-similar measures in dimensions one and two. The aim of this project is to build a theory covering measures generated by non-linear dynamics, and in arbitrary dimensions. One of the main objectives is to use novel transfer operator methods to characterise when measures generated by non-linear analytic conformal dynamics have power Fourier decay. Another goal is to make substantial improvements to the bounds for the decay exponent in many cases. The new Fourier decay estimates will be applied to establish fractal analogues of fundamental theorems of Khintchine and Gallagher in Diophantine approximation, and obtain new fractal uncertainty principles and Fourier restriction estimates in harmonic analysis. The researcher (PhD 2023) already has a track record of multiple cutting-edge works on the theory of Fourier decay of fractal measures, and on the dimension theory of iterated function systems. He therefore has the ideal blend of expertise in both fractal geometry and Fourier transforms to complete the ambitious objectives. The project will take place at the University of Jyväskylä in the group of T. Orponen, an ERC grantee working at the interface of fractal geometry and harmonic analysis.

Keywords: fractals,fourier transform,iterated function system,dynamical systems
Nuclear cooperation and conflict across symbiotic fungal networks (NUCLEAR MIX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Arbuscular mycorrhizal fungi (AMF) form one of the most widespread terrestrial symbiosis on earth with the roots of plants, known as mycorrhizal symbiosis. Multiple AMF connect with multiple plants simultaneously forming large underground common mycorrhizal networks (CMN) where carbon and nutrients are exchanged. In contrast to most organisms where a single cell carries a single nucleus, a single AMF cell holds thousands of nuclei. This mysterious multinucleate and clonal biology has generated open questions in evolutionary biology. First, AMF have been called “evolutionary scandals” for supposedly surviving millions of years without sex, contradicting the theory that lack of sex in eukaryotes should lead to extinction. Second, their permanent multinucleate nature has generated debates about what defines an AMF individual. My work, and others, recently demonstrated that AMF have a unique genetic organization, with some AMF containing - not one - but two genomes (nucleotypes). While we now know that variation in this genetic system exists, it is unknow: (i) how this genetic diversity is produced, (ii) whether this variation exists in absence of sexual reproduction, and (iii) whether this variation affects nutrient trade across mycorrhizal networks. By using high resolution molecular techniques, advanced microscopy, image analysis, and DNA/RNA fluorescence in situ hybridization, I will ask: What are the costs and benefits of nuclei mixing from single cells to across connected CMN networks? Working across three scales, I will test whether co-existence of two genetic nuclei groups result in sexual reproduction (WP1) how interactions affect the mycelia fitness of interconnected strains across CMNs (WP2) and how nuclei mixing affects plant response and plant community assembly (WP3). This work will challenge long held dogmas (AMF asexuality and network connectivity) and can help maximize the benefits of the mycorrhizal mutualism for agriculture.
Spin Glasses, Learning, and Optimisation in High Dimension (SLOHD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 1
Project status: SIGNED

This project aims at tackling problems in statistical mechanics, with a primary focus on spin glasses, followed by an exploration of machine learning related questions. Spin glasses, initially studied in the 1980s using non-rigorous methods by theoretical physicists, revealed complex behaviours which were previously unknown: They conjectured that the phenomenon they depicted should be present in many more models such as neuronal networks. From a mathematical perspective, spin glasses are disordered systems where each "spin" can be seen as a random variable, interacting with others through a network of complex, often conflicting, interactions. Recent recognition in the field, with Giorgio Parisi winning the Nobel Prize in 2021 and Michel Talagrand receiving the Abel Prize in 2024, highlights the importance of spin glass studies. However, many questions remain unanswered, particularly regarding the mixed Sherrington–Kirkpatrick model: the phase transition between the high and the low-temperature regime is not known rigorously. One key objective of the fellowship is to explore this phase transition mainly through a dynamical approach by viewing the disorder in the Hamiltonian as different Brownian motions, with temperature playing the role of time. Beyond spin glasses, the project will also investigate neural networks (specifically, one-hidden-layer models with a large but finite number of neurons): the algorithms underlying their training are still not fully understood, and we aim to elucidate why, despite the non-convexity of their objective, do they converge to a desirable solution? Although spin glasses and machine learning may seem unrelated at first glance, it is believed that many probabilistic techniques from spin glass theory can be applied to understanding machine learning algorithms, especially in high-dimensional settings. By bridging these two areas, the fellowship aims to deepen our theoretical understanding of both domains.

Keywords: spin glass,sherrington kirkpatrick,mean field,fluctuations,learning,stochastic gradient descent