Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Emergence of complex internal representations in humans (EMCOREP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Hungary
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-09-01
End date: 2016-08-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Human learning is uniquely complex and powerful in terms of its efficiency, its level of abstraction and its range of skills compared to any other species. The proposed research will investigate the fundamental cognitive and computational foundations of human sensory learning in adults and infants in an integrated interdisciplinary manner. We will carry out behavioural studies, computational analyses and theoretical work, and the questions in each of these domains will be rigorously linked to the topics explored in the other domains. The behavioural studies will question the generally upheld notion that low-level statistical learning of regularities and high-level “rule learning” of explicit rules, hierarchical memories, and emerging abstract social notions must be two fundamentally different and separate types of processes in the brain. Together with the computational analyses, they will explore how short and long-term memory is involved in acquiring new knowledge based on sensory experience. In the domain of theory, we will explore the idea that instead of simple associative learning, what human cortical learning can be best captured by is an optimal probabilistic computation based on previously developed internal models of the world. Finally, the inclusion of both adult and child studies that are essentially identical in their structure, we will test the generality of our findings giving a uniquely synergetic flavor to our approach.

Keywords: human memory,learning,infant,vision
Interplay of inflammasomes, commensals and pathogens at mucosal interfaces (INFLACOMM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2013-10-01
End date: 2017-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Inflammasomes are multi-protein complexes that control the activity of the cysteine protease caspase-1. Inflammasomes are assembled around one of several different sensor proteins, which enable inflammasome activation after sensing of diverse microbial and endogenous damage-associated molecules. Recently, I discovered a novel role for the NLRP6 inflammasome in regulation of the intestinal microbiota of mice. In its absence an altered microbiota, called dysbiosis, develops that increases the severity of experimentally-induced colitis. Strikingly, transfer of the altered microbiota to WT mice resulted in exacerbated colitis in these mice compared to normal WT mice. These findings highlight two important features of the interplay of host and microbiota. First, that deficiencies in the immune system may lead to pathologic aberrations in the commensal microbiota. In this proposal I will address how the NLRP6 inflammasome regulates the microbiota using newly generated gene-deficient mouse strains as well as germfree mouse models. The second implication is that the microbiota has a large effect on mucosal inflammatory processes that are largely regulated by its specific composition. Dysbiosis is observed in many human individuals with immune-mediated diseases, but its impact on other aspects of immunity is less well characterized. Hence, I intend to study the effects of the microbiota, specifically dysbiosis, on orchestrating anti-microbial immune responses, as well as the impact in host response to vaccination. Specifically, I will study vaccination and challenge models of bacterial and viral pathogens that enter through mucosal routes, i.e. Salmonella enterica and influenza virus. The knowledge emerging from this work is expected to expand our understanding of innate and adaptive immune responses to infection and pave the road for the development of new therapies and immune interventions against microbial pathogens.

Keywords: innate immunity,microbiota,intestine,ibd
microRNAs: ROLES IN AXON GUIDANCE DURING BRAIN WIRING (GUIDANCE-MIR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-09-01
End date: 2018-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The precise elaboration and specification of neuronal circuits is at the basis of any properly functioning nervous system. For circuits to be established, neurons form remarkably accurate connections with their target cells during development. How are these connections established? Neurons send out cell protrusions called axons, which navigate in a complex environment to reach their exact target, a process known as axon guidance or pathfinding. Understanding the key molecules that induce the formation of such precise circuits is crucial, because any failure in this process, either during development or following injury or disease, impairs the proper function of the nervous system. Such precision is achieved by tight regulation, in space and time, of guidance molecules and their concomitant signalling mechanisms. However the key molecules involved in this highly accurate regulation are to date largely unknown. Very recent findings have suggested that specific microRNAs (miRNAs) could be involved in this process. Indeed, I have shown that miR-124 contributes to regulating with high precision the temporal expression of receptor to cue and, with collaborators, that miR-134 is implicated in the turning response of axons. However the possibility that miRNAs play a crucial role in axon guidance is to date unknown. In addition, prediction algorithms strongly suggest that many miRNAs could be implicated in this process. Indeed, hundreds of miRNAs have been sequenced to date including many detected within the nervous system, but very few have known functions. I therefore propose to investigate whether and which miRNAs are key regulating molecules in axon guidance.

Keywords: developmental neurobiology,molecular and cellular neuroscience,bioinformatics,micrornas,axon guidance,in vivo
BOOST - Cooperation in Urban Science, Technology and Policy (BOOST)

Framework: FP7 — Capacities
Programme: Regions of Knowledge
Destination: Facilitating the emergence of new regional research driven clusters and mutual exchange of information
Action type: Coordination and support actions
Countries involved: Netherlands,Austria,Sweden,Italy,France,Norway,Cyprus,Türkiye,Finland
Call:  (FP7-JPROG-REGIONS-2013, 2013)
Start date: 2013-10-01
End date: 2016-01-31
Duration (months): 28.0
Total project cost (EUR): 2095406.0
EU funding (EUR): 1997924.0
Participants: 12
Project status: CLOSED

Cities are increasingly seen as "engines of regional development" and the main competitive hubs within a global web of economic, knowledge and physical flows. Cities are fertile ground for science and technology, culture, entrepreneurship and creativity. However, cities are also places where problems are concentrated, such as the decoupling of economic growth and employment, social and spatial segregation, poverty, environmental degradation and climate change. Europe’s competitiveness depends greatly on its cities and metropolitan regions, where enterprises can benefit from agglomeration economies and networks linking regional, national and global market places. In order to address the major challenges of cities a Joint Programming Initiative Urban Europe was launched in 2010 with the ambition to rethink and manage the increasing urban orientation and concentration in Europe and to create and exploit synergy in an urbanised Europe from an economic, social, environmental and transport-related perspective, leading to a strengthened position. 13 EU Member States and Associated Countries have therefore joined forces to coordinate and align their research programmes in order to boost urban research and innovation. BOOST – Cooperation in Urban Science, Technology and Policy, aims to support and strengthen the further establishment of JPI Urban Europe and facilitate effective internal and external communication of this initiative. It will do so by further establishing effective JPI governance structures, bridging scientific gaps, facilitating networking, launching a Research Alliance, outreach to the scientific, policy, industry and civic actors involved in urban development and by stimulating coordination efforts with stakeholders, funding agencies and other international programmes. As a result a sharply focused and realistic Strategic and Innovation Agenda (SRIA) for JPI Urban Europe will be developed and appropriate instruments for its implementation defined.

Keywords: urban development,cities,urban policy and innovation,coordination of research programmes,research alliance,multi-stakeholder involvement,trans- and multi-disciplinary research
Demonstration of integrated smart water supply solutions at 4 sites across Europe (SMARTWATER4EUROPE)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Improving resource efficiency
Action type: Collaborative project
Countries involved: Spain,United Kingdom,France,France,Netherlands,United Kingdom,Netherlands,United Kingdom,Netherlands,United Kingdom,Austria,Netherlands,Spain,Spain,Denmark
Call:  (FP7-ENV-2013-WATER-INNO-DEMO, 2013)
Start date: 2014-01-01
End date: 2017-12-31
Duration (months): 48.0
Total project cost (EUR): 10043233.2
EU funding (EUR): 5999288.0
Participants: 21
Project status: CLOSED

European water utilities face many problems related to their 3,5 million km’s of distribution networks. Large parts of water distribution networks have to be rehabilitated requiring investments of € 20 billion/year. Prioritization and optimization of investments is needed urgently. In many countries, water quality needs improvement in order to reduce health risks and resources for water production and distribution must be used more efficiently. The European Innovation Partnership on Water has established priority areas related to the challenges in water supply distribution networks, focusing on resource efficiency, Smart Water Management and decision support systems. Although the technology components for Smart Water Management are available, the route to application is still uncertain. The main hurdles are: lack of integrated and open solutions; difficulty to comply with user and integration requirements; lack of clear and validated business cases for solutions; lack of business intelligence awareness and lack of political and regulatory support. Project aims 1) To integrate and demonstrate 12 innovative solutions 2) To demonstrate 4 integrated solutions 3) To establish and guard integration and standardisation aspects 4) To establish business cases, deployment potential and market uptake routes Solution This project will overcome the hurdles by developing and demonstrating in 4 important Smart Water Management themes (water quality management, leak management, energy optimization and customer interaction). 12 innovative theme oriented solutions and 4 integrated (technological, financial, ICT, organisation, management) solutions will be demonstrated at 4 well-scaled and real-life demonstration sites in France, United Kingdom, Spain and The Netherlands. These solutions will be tested, validated and evaluated and business cases will be generated. Consortium 12 innovative SMEs, 3 water utilities, 3 research institutes, 1 company and 2 platform organisations.

Keywords: smart water management,water supply,sensors,measurements,real time,distribution network,data management,data processin,response strategies,integration
BIOMETAL DEMONSTRATION PLANT FOR THE BIOLOGICAL REHABILITATION OF METAL BEARING-WASTEWATERS (BIOMETAL DEMO)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Improving resource efficiency
Action type: Collaborative project
Countries involved: Spain,France,Portugal,Spain,Spain,Portugal,Spain,Spain
Call:  (FP7-ENV-2013-WATER-INNO-DEMO, 2013)
Start date: 2013-12-01
End date: 2017-11-30
Duration (months): 48.0
Total project cost (EUR): 4443716.8
EU funding (EUR): 2897706.0
Participants: 9
Project status: CLOSED

Heavy metal pollution is one of the most important environmental problems today even threatening human life. A large number of industries produce and discharge wastes containing different heavy metals into the environment and do not comply with current EU directives. BIOMETAL DEMO project aims at demonstrating the feasibility of the application of novel biotechnologies for the treatment of metal polluted wastewaters though the development of two pilot plants to be implemented in two metal polluting representative industries which are a mine and an electroplating company. Actual metal treatment technologies implemented in polluting industries fail to comply with the reduction of metal concentration required by the EU for wastewater treatments. For this reason, new technologies will be developed to overcome this problem. The biotechnologies that will be evaluated in BIOMETAL DEMO project will be: metal bioprecipitation by sulphate-reducing bacteria and immobilized phytase biocatalysis, and metal biosorption on agricultural industry by-products and biopolymers such as alginate & chitosan based materials. After the evaluation of these techniques, an optimized bioprocess or a synergy of two integrated bioprocesses will be selected to design and build two demonstration pilot plants for scaling-up the metal removal biotreatment. The feasibility of the application of the selected bioprocess will be explored at pilot plant scale in acid mine drainage and electroplating wastewaters contaminated with heavy metals. The operation will be monitored and optimized, and the kinetics and the performance of the metal removal/recovery bioprocess will be integrated within the pilot demonstration plants. Finally, an economic, social and technical analysis of the benefits of such tertiary biotreatment of metal polluted industrial wastewater will be carried out for the corresponding and related industrial sectors across EU.

Keywords: heavy metal,pollution,wastewater,industry,biotechnology,bioprecipitation,sulphate-reducing bacteria,phytase,biosorption,agrofood by-products,alginate,chitosan,demonstration,pilot plant
Nanoelectronic COupled Problems Solutions (NANOCOPS)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Alternative Paths to Components and Systems
Action type: Collaborative project
Countries involved: Germany,Germany,Germany,Germany,Austria,Belgium,Czechia,Netherlands,Belgium,France,Germany
Call:  (FP7-ICT-2013-11, 2013)
Start date: 2013-11-01
End date: 2016-10-31
Duration (months): 36.0
Total project cost (EUR): 5036733.0
EU funding (EUR): 3499000.0
Participants: 12
Project status: CLOSED

Designs in nanoelectronics often lead to problems that are large to simulate and that include strong feedback couplings. Industry demands to include variability to guarantee quality and yield. It also requests to incorporate higher abstraction levels to allow for system simulation in order to shorten design cycles, while preserving accuracy. The nanoCOPS project considers the simulation of two problem classes identified by industry:- Power-MOS devices, with applications in energy harvesting, and which involve couplings between electromagnetics (EM), heat, and stress, and- RF-circuitry in wireless communication, which involves EM-circuits-heat coupling and multirate behaviour, together with analogue-digital signals.Due to the market demands, the scientific challenges are to- create efficient and robust simulation techniques for strongly coupled systems, that exploit the different dynamics of sub-systems and that can deal with signals that differ strongly in the frequency range;- include variability such that robust design, worst case analysis, and yield estimation with tiny failures are possible (including large deviations like 6-sigma);- reduce complexity such that one can still vary parameters and such that the reduced models offer higher abstraction models that are efficient to simulate.Our solutions are- advanced co-simulation/multirate/monolithic techniques, combined with envelope/wavelet approaches;- new generalized techniques from Uncertainty Quantification (UQ) for coupled problems, tuned to the statistical demands from manufacturability;- enhanced, parameterized Model Order Reduction techniques for coupled problems and for UQ.All algorithms will be validated in the industrial design tools provided by our industrial partners.Our consortium covers extensive R&D experience in nanoelectronic IC simulation and complementary expertise. It includes seven universities, one research institute, two large-scale semiconductor companies, and two SMEs.

Keywords: electromagnetics,circuit simulation,heat simulation,coupled problems,co-simulation,multirate,envelope techniques,model order reduction,uncertainty quantification,reliability,ageing
Lithuanian Presidency Conference “Enhancement of European International Cooperation and Eastern Partnership in RDI” (EEP 2013)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Activities of International Cooperation
Action type: Coordination and support actions
Countries involved: Lithuania
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2013-05-01
End date: 2013-12-31
Duration (months): 8.0
Total project cost (EUR): 109700.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Lithuanian Presidency conference “Enhancement of European International Cooperation and Eastern Partnership in R&D&I” (EEP 2013) focuses on cooperation in R&D&I on the international level with special emphasis on Eastern Partnership (Ukraine, Belarus, Moldova, Georgia, Armenia and Azerbaijan) in the context of European Research Area, Innovation Union, Europe 2020 and Eastern Partnership Roadmap. The conference in Lithuania will cover the issues related to the EU current policies on R&D&I and Eastern Partnership dimension and the future plans for Horizon 2020, as well as sharing good practices among different Member States and Eastern Partnership countries. EEP2013 will bring together the main stakeholders, including the European Commission, national policy making bodies, broad research community, those who are interested in international dimension of EU policies and cooperation with Eastern Partnership countries on R&D&I. The conference outcome – the declaration – will provide suggestions for improvements on international relations and further possible steps in International and Eastern Partnership. It may become the basis for a future Roadmap.

Keywords: eastern partnership,international cooperation,r&d&i,presidency
Open the Access to photonics life Science Infrastructure for SMEs (OASIS)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Alternative Paths to Components and Systems
Action type: Coordination and support actions
Countries involved: France,Italy,France,United Kingdom,Sweden,Germany,Spain,Netherlands
Call:  (FP7-ICT-2013-11, 2013)
Start date: 2013-12-01
End date: 2016-05-31
Duration (months): 30.0
Total project cost (EUR): 1253779.0
EU funding (EUR): 1050000.0
Participants: 10
Project status: CLOSED

The large scale research facilities and technology platforms are usually defined as a set of experimental instruments and components that are available mainly to academics and to a certain extent to industrials. The management of open access for researchers and world-class research programmes between these facilities is under consolidation through existing programmes like Instruct, EuroBioimaging. Large companies have created strong collaboration with these facilities but there is still a place for improving the economic outputs of this research and the involvement of SMEs in creating value and employment from these early scientific results. Photonics clusters and national platforms, as a strong link between Science and Economy, as well as between the regional and international environments, will play a key role in the organization of the collaboration between these facilities and the European SMEs. 7 European countries (France, UK, Germany, Sweden, Netherlands, Italy, Spain) gathered 70% of the new infrastructures in Life Sciences in last FP7. Nine photonics clusters from these countries, involved in initiatives supporting Biophotonics at the regional or national level define the 30-months OASIS Support Action. The consortium will realise an inventory to geographically map the former European investments made in Photonics Life Science facilities, to make them more easily accessible to SME. Targeting the right facilities is a prerequisite for efficient innovation but the right definition of further collaboration is still a challenge. OASIS partners will design services to improve collaboration framework between facilities, SMEs, hospitals, industrials in product development and validation. These actions should bring Europe SMEs a competitive advantage in new product development and a faster access to their markets by increasing available funding on these technologies and by reducing both cost and time of technical development.

Keywords: biophotonics - life science - agro and food market facilities - infrastructures platforms - photonic clusters