Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Monitoring Atmospheric Composition and Climate -III (MACC-III)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Coordination and support actions
Countries involved: Austria,Germany,Germany,Ireland,Germany,Spain,Germany,Germany,Germany,Greece,Greece,Sweden,Norway,Norway,Belgium,Finland,France,France,France,France,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal,United Kingdom
Call: SPACE (H2020-Adhoc-2014-20, 2014)
Start date: 2014-08-01
End date: 2015-08-31
Duration (months): 13.0
Total project cost (EUR): 5000000.0
EU funding (EUR): 5000000.0
Participants: 41
Project status: CLOSED

MACC-III is the last of the pre-operational stages in the development of the Copernicus Atmosphere Service. Its overall institutional objective is to function as the bridge between the developmental precursor projects - GEMS, PROMOTE, MACC and MACC-II- and the Atmosphere Service envisaged to form part of Copernicus Operations. MACC-III will provide continuity of the atmospheric services provided by MACC-II. Its continued provision of coherent atmospheric data and information, either directly or via value-adding downstream services, is for the benefit of European citizens and helps meet global needs as a key European contribution to the Global Climate Observing System (GCOS) and the encompassing Global Earth Observation System of Systems (GEOSS). Its services cover in particular: air quality, climate forcing, stratospheric ozone, UV radiation and solar-energy resources. MACC-III’s services are freely and openly available to users throughout Europe and in the world. MACC-III and its downstream service sector will enable European citizens at home and abroad to benefit from improved warning, advisory and general information services and from improved formulation and implementation of regulatory policy. MACC-III, together with its scientific-user sector, also helps to improve the provision of science-based information for policy-makers and for decision-making at all levels. The most significant economic benefit by far identified in the ESA-sponsored Socio-Economic Benefits Analysis of Copernicus report published in July 2006 was the long-term benefit from international policy on climate change. Long-term benefit from air quality information ranked second among all Copernicus benefits in terms of present value. Immediate benefits can be achieved through efficiency gains in relation to current policies. The estimated benefits substantially outweigh the costs of developing and operating the proposed services.

Keywords: copernicus,atmospheric composition,air quality,climate forcing,ozone layer,emissions,surface fluxes,solar radiation
Controllable Growth and Charge Carrier Transport of Fibrillar Microstructure of Semiconducting Polymers in Field-Effect Transistors and Photovoltaics (FibrillarMICROSTRUCT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Semiconducting polymers have attracted extensive attention due to their potential applications in organic field-effect transistors (OFETs) and organic photovoltaics (OPVs), but it is still a great challenge to modulate their microstructure in a controllable way. In this proposal, I will outline how the controllable growth of a fibrillar microstructure can be realized using diketopyrrolopyrrole (DPP) polymers. On the one hand, quasi polymer crystals such as fibers or wires will be deposited, leading to the fabrication of high-mobility transistors due to an almost complete elimination of grain boundaries. Such quasi polymer crystals will provide an ideal platform for the investigation of charge carrier transport. On the other hand, hierarchical microstructures of DPP polymers with two distinct characteristic fiber diameters will be grown in polymer/fullerene blend films in a controllable way, in which the thick fibrils (~100 nm) will be beneficial for the charge carrier transport and the thin fibrils (~10 nm) will facilitate the exciton generation and charge separation in polymer solar cells. The controllable growth of a fibrillar microstructure including quasi polymer crystals and hierarchical microstructures will allow me to systematically study the correlation between film microstructure and device performance in both OFETs and OPVs. This will open new prospects for the fabrication of high-performance polymer electronic devices and create the opportunity to reveal the intrinsic mechanism of charge carrier transport in semiconducting polymers.

Keywords: polymer solar cell,polymer transistor,polymer fibril,charge transport
Advanced Data Modeling and Analysis Applied to next Generation Industry 4.0 settings and the Internet of Things (DATAMINE4.0)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-22
End date: 2020-01-21
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

DATAMINE4.0 is an IF for Career Development for Natasa Sarafijanovic-Djukic, PhD in Computer/Communication Sciences obtained from EPFL, Switzerland, a researcher in statistical modelling originally from Serbia, whereby she will work in IRIS, a Spanish R&D and advanced engineering SME. The project will study the modeling and analysis of data coming from complex industrial and organizational applications, in order to identify hidden causistic relationships in order to calibrate production and organizational control systems. It is highly multidisciplinary combining data science, statistics, artificial intelligence, telecommunications, specific engineering and organizational domains and information technology processing competences. In line with new paradigms such as Industry 4.0 and the Internet of Things. Although machine learning paradigms have been in existence for several decades, their penetration in the industrial and public organization setting has been limited. The goal is to build calibration and optimization models using advanced statistical and machine learning methods and other artificial intelligence inspired algorithms, for applications in which existing methods have been unsatisfactory. This will have a big impact on productivity and repeatability of winning formulas for key industrial applications such as customized production, public sector applications (e.g. optimization of urban mobility), and food processing. This is in line with findings published by the European Union. The developed data mining solutions will greatly enhance the current performance of the selected applications, allowing them a competitive advantage over current methods. The work will be done in an applied R&D environment in line with the objective for Dr. Natasa Sarafijanovic-Djukic’s career continuation. An engineering approach will be ideally completed with 7 formal scientific trainings, including two academic secondments, each of 2 months.

Keywords: data mining,industrial process optimisation,data analysis,network analysis,data fusion,graph analysis
Capturing the biomineralization of magnetite nanoparticles with magnetotactic bacteria in vivo using microfluidic conditions and synchrotron-based X-ray spectroscopy (BioNanoMagnets)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Magnetotactic bacteria (MTB) produce highly organized chains of magnetite nanoparticles within intracellular membranes called magnetosomes. The alignment of these magnetic nanoparticles endows the bacteria with a substantial magnetic dipole, which it can use in relation to the earth’s magnetic field to navigate its environment. Magnetite nanoparticles of consistent size, composition and shape are produced by MTB through biomineralization processes. The specific morphology of magnetite nanoparticles is species-determined. Magnetite biomineralization and MTB have been of interest for several years as scientists try to understand the chemical mechanism for the highly efficient production of magnetite nanoparticle materials. Harnessing or adopting chemical pathways similar to the bacteria should benefit the production and utility of magnetite nanoparticles for technological advancements in areas such as medical diagnostics and drug delivery nanosystems. This project aims to capture and understand the formation and properties of magnetite nanoparticles within living MTB. This information will be unique from previous studies since biomineralization processes will be followed in vivo and with high-resolution, synchrotron-based spectroscopy techniques. To accomplish this objective, bacterial samples will be hosted in microfluidic sample cells with X-ray transparent cell windows capable of in situ measurement using a combination of X-ray absorption and X-ray scattering spectroscopies. Microfluidic cell design and measurement conditions will be optimized for MTB viability. Elucidating the magnetite biomineralization process and the full formation of magnetosomes within live bacteria will provide unprecedented chemical and structural details without having to destroy the bacteria before measurement.

Keywords: biomineralization,magnetite,nanoparticles,x ray spectroscopy,biomaterials
Dissecting the Functional and Therapeutic Impact of Somatic Copy Number Alterations (SCNAs) (CrispSCNAs)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1400000.0
Participants: 2
Project status: SIGNED

In 1914 Theodor Boveri described abnormal chromosome counts in cancer cells and speculated that these alterations are the driving force of cancer. Almost 100 years later it became clear that somatic copy number alterations (SCNAs) are one of the most striking characteristics of cancer genomes. SCNAs comprise deletions and amplifications of whole chromosome arms and therefore alter the expression patterns of several hundred genes simultaneously. These alterations show defined patterns suggesting selective pressure, and thus likely contain multiple driver genes, which can shape several tumorigenic properties. Therefore, studying how these events contribute to tumor development will be fundamental to understand cancer biology and develop targeted cancer therapies. However, whereas the function of recurrently mutated driver genes can be readily assessed, studying SCNAs remains challenging so far. This project will overcome these limitations by combining our unique ability to model liver cancer in vivo and in vitro with innovative CRISPR-based genomic engineering technologies. First, we will generate large chromosomal deletions in murine livers and human-derived liver organoids by CRISPR technologies and assess their functional role in cancer development. Furthermore, synthetic lethal interactions generated by these deletions will be evaluated on their therapeutic potential. Additionally, driver genes and driver gene-combinations of amplified chromosomal regions will be investigated using a novel CRISPR/Cas9-based mouse model for endogenous gene activation and chromosome engineering. Finally, we will exploit a novel concept for targeting cancer cells with specific amplifications. Our unique approach will for the first time systematically investigate the functional role of SCNAs in tumor pathobiology, identify new therapeutic strategies specifically tailored for individual SCNAs, and will therefore have high impact for future efforts to understand and combat cancer.

Keywords: liver cancer,mouse models,somatic copy number alterations,pathology,crispr,cas9,functional genomics
NUclear COmponents Based on Additive Manufacturing (NUCOBAM)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Nuclear safety
Action type: Innovation actions
Countries involved: Spain,Belgium,Belgium,Sweden,Finland,France,France,United Kingdom
Call: Innovation for Generation II and III reactors (NFRP-2019-2020, 2019)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 4067916.75
EU funding (EUR): 2999324.85
Participants: 13
Project status: SIGNED

NUCOBAM aims at developing the qualification process and provide the evaluation of the in-service behaviour allowing the use of additively manufactured components in nuclear installation. Additive Manufacturing (AM) will allow nuclear industry (i) to tackle component obsolescence challenges and (ii) to manufacture and operate new components with optimised design in order to increase reactor efficiency and safety. NUCOBAM will conduct the required studies to implement AM process in nuclear design codes and standards to produce components for nuclear power generation equipment. The project will be based on two coupled strategies. The first part will consist of a collection of the physical, mechanical and microstructural characterization of the materials that result from AM process in order to establish a qualification and codification process. The second part will be dedicated to the evaluation of AM material behaviour in service, especially regarding main degradation mechanisms that occur in LWR (thermal ageing, irradiation…). Materials will be manufactured and some of them will be submitted to post-treatment (heat treatment or high isostatic pressure). The results will be analysed and compared with existing approved manufacturing processes by design codes. This work will lead to evaluate and deduce the main parameters required for specification. NUCOBAM will gather leading edge organisations able to pull the complementary expertise and capabilities mandatory to demonstrate the use of AM components in a nuclear installation. The consortium will thus involve electricity utilities, operating nuclear assets, component manufacturers, design owners, public service experts in nuclear and radiation risks as well as research and competence centres involved in mechanical assessment, metal powder qualification, metallurgical characterization, materials irradiation capabilities and nuclear power research.
THE BLACK SEA BASIN, A CRADDLE AND REFUGE OF EUROPEAN BIODIVERSITY (DarkLife)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

In the last years, human activity has rapidly accelerated the rate of biodiversity loss, compromising the vital goods and services ecosystems provide to sustain well-being, and future economic and social development. The Black Sea Basin is listed among the WWF’s “top priority places” for conservation. Its unique biota, however, is serious threatened by illegal logging, intensive agriculture and unsustainable coastal development. Although the Black Sea Basin biodiversity is reasonably well characterised, many questions about its origin and relevance for present-day European natural heritage remain. The The DarkLife project aims at improving our current knowledge on the origins and diversification of terrestrial invertebrates in the Black Sea basin – a neglected refuge for survival of species during Quaternary glaciations and an important centre of origin and subsequent dispersal of a unique component of European wildlife. To tackle this ambitious goal, I will combine integrative taxonomic research with high-throughput DNA sequencing (HTS) techniques and state of the species distribution modelling (SDM) tools. I will use spiders as a model system organism. I will gain expertise on modern systematic and evolutionary biology research through training in two leading European institutions, the University of Barcelona, the top ranked university in Spain, and the Senckenberg Biodiversity and Climate Research Centre (BiK-F) in Germany. The results of the DarkLife project will help me to reveal the factors and mechanisms that shaped the Black Sea basin unique biodiversity melting pot, unravel its origins and dynamics and, more importantly, predict how global warming may affect its future viability. The training provided by the MSC will help me to secure a scientific position in Bulgaria and become an active player in the development of future conservation policies and sustainability programs my home country.

Keywords: systematics,evolutionary biology,hight throughput dna sequencing,species distribution modelling,climatic change,conservation biodiversity,wildlife,taxonomy,zoogeography
TL; DR (Too Long; Didn’t Read): Close and hyperreading of literary texts and the modulation of attention (TLDR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 253052.16
EU funding (EUR): 253052.16
Participants: 2
Project status: SIGNED

In the information age, technological developments have drastically increased the amount of texts available through different media. This has led to a shift in reading habits from close reading, sustained and focused attention to the text, to hyperreading, non-linear, computer-assisted modes of reading such as skimming and scanning. Consequently, some fear, young people are losing the ability to concentrate. Many scholars align literary reading with close or deep reading and maintain a strict binary conception of this mode and hyperreading at the opposite pole. TDLR proposes that (a) readers tend to modulate between the two modes, that are more integrated than is often assumed and that (b) this is especially true for literary reading, as literary texts demand of their readers to switch between close and hyperreading. The research project will therefore ask: Does reading literature help to make us better at allocating and modulating attention? What elements in literature prompt readers to pay close attention, and what elements invite a more distracted reading? Are experienced literary readers more skilled at determining when to zoom in and close read, and when to skim? And is this skill transferable to non-literary (information) environments and texts? This study will combine textual analysis with questionnaires, eye-tracking experiments, and interviews to answer these questions.

Keywords: attention,concentration,close reading,culture,distraction,education,digitalization,hyperreading,literary reading
DOLORisk: Understanding risk factors and determinants for neuropathic pain (DOLORisk)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Israel,Iceland,Spain,Belgium,Sweden,France,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Understanding health, ageing and disease: determinants, risk factors and pathways (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-07-01
End date: 2020-09-30
Duration (months): 63.0
Total project cost (EUR): 5981219.5
EU funding (EUR): 5981219.5
Participants: 12
Project status: CLOSED

Neuropathic pain (NP) is common (population prevalence of 7-8%) and will present a rising health burden in the future. NP results in significant morbidity, reduces quality of life and has a major deleterious impact on health in aging. The reason why some subjects develop neuropathic pain and others do not following the same injury is not known. The exact nature of risk factors for NP and their interaction are currently poorly understood and will be the focus of this project. We will establish an international consortium of leading researchers in the field of NP (DOLORisk consortium) involving members of established academic European consortia studying pain/genomics and neuropathy as well as the SMEs Neuroscience Technologies and Mentis Cura. The project will be highly translational and the starting point will be the study of patients with NP or at risk of developing NP. Specific objectives will be to: 1) Identify the influence of demographic factors, environmental/societal and clinical factors on the risk of developing and maintenance of NP 2) To apply modern genomics to validate (using a targeted approach) and find novel (using genome wide association) genetic risk factors for NP. 3) Use tissue samples and patient derived cells from Biobanks to validate of molecular pathways contributing to chronic pain in patients. 4) To determine if patient stratification using physiological (sensory profile, endogenous analgesic mechanisms and nerve excitability) and psychological factors can predict NP risk and progression. 5) Development of a risk model/algorithm for (severe) NP, combining measurable genetic and environmental factors. Our aim is to understand pain pathophysiology in terms of risk factors and protective mechanisms ranging from molecular pathways to societal impacts. The desired impact is to provide a firm platform to improve diagnosis and stratify patients according to risk profile, employ preventive strategies and ultimately develop novel therapeutics.

Keywords: neuropathic pain,quantitative sensory testing,peripheral neuropathy,genotype,diabetes mellitus,aging