Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative tools for rational control of the most difficult-to-manage pests (super pests) and the diseases they transmit (SuperPests)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Spain,Belgium,Greece,Belgium,Belgium,France,Netherlands,United Kingdom,Canada
Call: Innovations in plant protection (H2020-SFS-2017-2, 2017)
Start date: 2018-09-01
End date: 2023-02-28
Duration (months): 54.0
Total project cost (EUR): 3095900.0
EU funding (EUR): 2991525.0
Participants: 14
Project status: SIGNED

Among the most acute challenges that many producers of fruit and vegetable crops currently face are a subset of arthropod pest species - namely aphids, whiteflies, thrips and mites - that are extremely difficult to control (the “super pests”). These issues have been caused, in part, by the over reliance on synthetic insecticides and novel methods of control are urgently required. The SuperPests project aims to meet this need by developing and evaluating a suite of innovative products, tools and concepts, and integrating these with existing approaches in data driven Integrated Pest Management (IPM) programs. These control strategies will ensure the effective and sustainable control of the “super pests”, with substantially reduced use of pesticides. To achieve this SuperPests will develop multiplex and automated sample-to-answer diagnostics (biotypes, infection status and insecticide resistance profile), evaluate biopesticides (green chemistry – plant extracts & metabolites, synergists, RNAi and bio-stimulants), study host plant resistance to pests and compatibility with biological control, select natural enemies better suited to certain crops and IPM, and develop predictive mathematical models, iteratively validated against experimental data, to determine optional combinations for IPM. Successful completion of the deliverables of SuperPests will create opportunities for the commercial exploitation of the new tools and products. The previous experience of the consortium members with a whole range of multi-actor and multidisciplinary approaches and cutting-edge translational technologies, the extensive synergies with parallel large international programs, and the inclusion of appropriate companies places the SuperPests team in a strong position to generate knowledge and create smart tools and practices which ensure pest control while protecting the environment and human health.

Keywords: biopesticide,green chemistry,insecticide resistance,diagnostic,whiteflies,aphids,mites,thrips,model,biological control,plant resistance
Passive layER FailuRe Mechanisms for Steel Embedded in Alkali-Activated Slag Materials (PERFoRM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-03
End date: 2021-06-02
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

PERFoRM will unveil how in-service environmental conditions influence the stability of the passive layer on steel rebar embedded in concretes based on low-carbon cementitious materials (i.e. near-neutral salt activated slag materials (NnSAS)), when exposed to environmental threats. NnSAS offer high carbon emission savings, compared to other construction materials, however their long-term performance is largely unknown. PERFoRM will implement non-destructive techniques (NDTs) for the in-situ diagnosis of steel reinforced concretes, and in-situ tracing of aggressive ions; along with cutting-edge electrochemical techniques to determining corrosion rates closely resembling in-service concrete structures. Advanced characterisation of the passive layer using environmental XPS, and the steel-concrete interface using u-CT will also be carried out. The main scientific focus areas of PERFoRM will be: • Developing novel durability wireless embedded (D-WirE) sensors for in-situ tracing of aggressive ions (e.g., chlorides) and monitoring of internal factors (e.g. relative humidity, pH) in concrete • Ground-breaking work monitoring chemical and physical changes induced by carbonation/chloride penetration in NnSAS mainly using NDTs • Advanced characterisation of the passive layer growth, breakdown, and failure rates of steel rebars embedded in NnSAS • Creation of service-life models by incorporation of in-situ carbonation and chloride penetration regression models PERFoRM will bring unique insight about all potential aspects influencing corrosion mechanism and stability of the passive layer forming in steel embedded in NnSAS. This will enable performance-based materials design, and selection of remediation strategies to ensure the safety of in-service novel self-sensing and low-carbon NnSAS. PERFoRM will be integrated with collaborative programmes coordinated by RILEM and EFC, providing a direct route to international awareness and utilisation of the fellowship outcomes.

Keywords: corrosion,non destructive techniques,sensors,electrochemical properties,steel concrete interface,alkali activated materials
Media Homes: Housing Precarity on Screen in Ireland, Portugal and the UK from the 2008 crisis to COVID-19. (MEDIAHOMES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-12-01
End date: 2023-11-30
Duration (months): 24.0
Total project cost (EUR): 184590.72
EU funding (EUR): 184590.72
Participants: 1
Project status: SIGNED

This project aims to carry out ground-breaking work on European film and media representations of the home and their networks of production and circulation from the 2008 economic crisis to the COVID-19 emergency. It will take as case studies Ireland, Portugal and the UK to investigate representations of the home, housing precarity and homelessness, focusing on the aspect of socioeconomic inequality across gender, race and class. Its overall objective is to devise, through a strongly interdisciplinary methodology combining methods in the humanities with studies in the social sciences, a new, transnational model to analyse screen narratives of housing precarity, their production and circulation. Across a range of documentaries, essay films, realist features and short non-fiction films the project will investigate the representation of an ongoing housing crisis and trace their intersections with the developing corpus of housing precarity in the lockdown and the pandemic. Within this corpus, I will consider three modes of media activity: 1) representation 2) production and 3) circulation (distribution and screening). The main research objectives of the action are: 1) to build a transnational corpus of media representations of the urgent challenge of housing precarity and inequality within European cinema and to provide an innovative model for its analysis across media genres, 2) to understand who the subjects producing this corpus are and whether filmmakers from a variety of gender, race and class backgrounds have equal access to representation or not 3) to understand how films about housing circulate across different platforms online and offline and in society at large 4) to investigate how these productions have been affected by the transformation of the home into a site of creative labour during the pandemic and how this intersects with socioeconomic inequality.

Keywords: film,media,home,housing,inequality,gender,class,race,crisis,urban space,covid 19
Sleep balancing abstraction and forgetting of memory (SleepBalance)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-11-01
End date: 2025-10-31
Duration (months): 60.0
Total project cost (EUR): 2449593.75
EU funding (EUR): 2449593.75
Participants: 1
Project status: SIGNED

Sleep supports the formation of long-term memory, a function described as an active systems consolidation process. Concurrently, a long tradition of theorizing exists that sleep serves to forget unimportant memory. Paradoxically, the crucial behavioral demonstration that sleep induces forgetting is currently entirely missing. I hypothesize that memory processing during sleep is balanced: Sleep consolidates abstracted schema-like memory and this process is coupled to active forgetting of episodic detail. This twofold function of sleep is most prominently expressed, with a time delay, after learning large amounts of information exhausting the limited capacities of memory processing during sleep. It is particularly pronounced during development when due to a lack of preexisting knowledge, the brain faces conditions of permanent information overload. I will combine human and rodent studies to test the behavioral predictions of this hypothesis and to characterize the underlying neural mechanisms. Adopting the active systems consolidation framework, I target the following aims: 1) to provide direct behavioral evidence that with high information load, sleep compared to wakefulness induces forgetting of episodic detail in favor of consolidating abstracted schema-like memory. 2) to clarify how memory abstraction and forgetting are linked to slow wave sleep (SWS) and REM sleep, their characteristic EEG oscillations, and underlying forming and pruning of synapses. Specifically, I hypothesize that spindles support memory abstraction whereas slow oscillations, hippocampal ripples and REM theta concurrently contribute to both memory abstraction and forgetting. 3) to demonstrate enhanced sleep-dependent memory abstraction and forgetting during early development. This project by providing first-time systematic evidence that and how sleep transforms memory to induce forgetting, will greatly advance our understanding of sleep’s memory function and its multiple applications.

Keywords: memory,sleep
Atomic Quantum Emitters in 2D Frameworks (AQE2D)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2139400.0
EU funding (EUR): 2139400.0
Participants: 1
Project status: SIGNED

The ability to create and control connected quantum states established the advent of quantum information technologies (Q-IT). Manipulation of the electron spin associated with colour centres in solid state crystals is one of the pillar technologies that could eventually push Q-IT beyond cryogenic environments. Exploitation of the full potential of these atomic qubit systems is, however, hampered by two key challenges: the lack of atomistic insights into their properties, and the ability to place them with the required fidelity and atomic spatial precision. Here I propose to converge recent breakthrough developments in the synthetic control of two-dimensional (2D) materials and ultra-fast, single-atom resolving probes to overcome these challenges. Specifically, I will develop a platform for electro-optically addressable spin qubits (Atomic Quantum Emitters, AQEs) in 2D materials based on atomic dopants in transition metal dichalcogenide (TMD) monolayers and molecular spin systems in 2D covalent organic frameworks (2D-COFs). These systems will provide an ideal platform to generate AQEs by chemical design, to control the mesoscopic environment averting variability between emitters, to achieve atomically precise spatial placement, to identify and eliminate decoherence channels, and to develop high-fidelity scalable pumping schemes. The proposed construction of a spin-polarized ultrafast THz scanning probe microscope with optical detection capabilities will enable the direct correlation of structural, electronic, magnetic, and optical properties of individual AQEs with simultaneous atomic spatial resolution and picosecond time resolution. This will open new frontiers in the spatio-temporal characterization and control of solid-state AQE systems. The atomically precise engineering of 2D quantum materials and unprecedented microscopic insights into AQEs bear transformative potential for the field of quantum sensing, communication and information processing.

Keywords: engineered artificial atom states,low dimensional quantum materials,ultra fast scanning probe microscopy,pump probe thz spectroscopy,atomic precision technologies
Major depression as a metabolic disorder: The role of oxygen homeostasis and mitochondrial bioenergetics in depression etiology and therapy (MitO2Health)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1999363.75
EU funding (EUR): 1999363.75
Participants: 1
Project status: SIGNED

MitO2Health aims to develop and empirically prove a radically new pathophysiological model of Major Depressive Disorder (MDD) as a systemic energy deficiency disease. Traditionally, MDD is conceptualized as a neurotransmitter deficiency in the brain. However, with pioneering methods my group has provided evi-dence for reduced mitochondrial energy production in MDD, characterizing it as a cellular-metabolic disorder with a lowered production of adenosine triphosphate (ATP). Reduced mitochondrial bioenergy production and impairments in oxygen (O2) homeostasis (reduced levels of erythrocytes, less hemoglobin and its lower O2-binding affinity due to oxidative stress), as well as oxidative stress and inflammation (the “MitO2Health parameters”) were consistently associated with an increased risk for MDD, but have been neglected so far in MDD research and therapy. In MitO2Health we will more comprehensively than ever before investigate the physiological mechanisms underlying MDD and will provide first longitudinal evidence on the mutual in-terplay between the MitO2Health parameters and MDD. Moreover, we will apply cognitive-behavioral therapy (CBT) as randomized treatment condition to test whether CBT-related MDD symptom reduction is coupled to a normalization of the MitO2Health parameters. We will treat 100 MDD patients with 6 months of CBT and compare them to 100 MDD patients of a waiting-list group and 100 healthy controls. Clinical and biological status will be assessed at four points over 18 months. We will thus characterize the biomarker pro-files of MDD treatment response and resistance as well as MDD symptom recurrence during a follow-up pe-riod. MitO2Health will not only establish a modern etiological model of MDD, but also identify biomarkers of individual therapy response and relapse. This will lead to new diagnostic standards and inspire personalized MDD treatment concepts that will fundamentally improve clinical outcomes in psychotherapy and psychiatry.

Keywords: clinical psychology,stress,chronic and traumatic stress,depression,major depressive disorder,inflammation,oxidative stress,mitochondria
Philosophy of Pharmacology: Safety, Statistical standards and Evidence Amalgamation (PhilPharm)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Germany,Italy,Denmark
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2020-03-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 643084.05
Participants: 3
Project status: CLOSED

The project intends addresses safety assessment in pharmacology with a view on philosophical work on causality and causal inference from statistical data ((Pearl 2000; Spirtes, Glymour, Scheines 2000, Woodward 2003, Cartwright, 2007b). This interest is motivated by the fact that current evidence standards emphasize internal validity of studies and hence randomization, disregarding alternative routes to causal assessment, such as the joint support of different sorts of evidence to a given hypothesis. This may be particularly detrimental in that, much of the evidence for harms comes from anecdotal reports, case series, or survey data, which standard guidelines of evidence evaluation regard as being of poorer quality with respect to controlled (randomized) experiments. Although the role of this "lower level" evidence is increasingly acknowledged to be a valid source of information for the risk profile of medications (Howick et al. 2009, Hauben and Aronson, 2007), current practices have difficulty in assigning it a precise epistemic status and integrating it with more standard methods of hypothesis testing. The philosophical debate has already addressed similar questions in relation to the assessment of treatment efficacy (Worral 2010, Papineau, 1993; Cartwright, 2007). However, none of these contributions expressly addresses the specific issues arising in causal assessment for harms. The project intends to change the evidence standards for safety assessment by providing a unified framework for the amalgamation of diverse evidence in safety assessment. In particular, the project intends to: 1) present a foundational analysis on statistical/causal inference with a focus on safety assessment; 2) Build a unified epistemic framework within which different kinds of evidence can be combined and used for decision; 3) Provide the theoretical framework for the development of new standards of drug evaluation.

Keywords: philosophy of science,bayesian epistemology,evidence,causal modelling,bayesian nets,adverse drug reactions,risk management
EEN Advanced Support Services for Walloon SMEs 2015-2016 (KAMWAL 2.1)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Belgium,Belgium,Belgium,Belgium,Belgium,Belgium,Belgium
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 148750.0
EU funding (EUR): 148750.0
Participants: 11
Project status: CLOSED

The KAMWAL 2.1 project is the proposal to establish services “Enhancing the innovation management capacity of SMEs” in the Enterprise Europe Network for Wallonia. Indeed, thanks to the KAMWAL 2.1 project, 4 Walloon organisations all members of the Entreprise Europe Wallonie consortium will propose two advanced support services to Walloon SMEs during the period 2015-2016. Firstly, the Key Account Management (KAM) service designed for SMEs beneficiaries of the EU SME Instrument scheme in order to help them to access and to take advantage of the support of specialized coaches. Secondly, the enhanced Innovation Management capacities (IM) service which proposes an evaluation of the Innovation Management System through specialized tools. In order to have at our disposal tools meeting several types of possible clients profiles and needs, the project will use 2 tools, mainly the IMPROVE tools but also the Gazelle Leap tool, may be less quantitaive, but already in place in our national environment. In both cases, results will lead to individual action plans which will be put into operation and progressively realized thanks to the support tools available in Wallonia with a.o. Enterprise Europe Network tools and services and tools coming from the regional innovation support system. Both services will be operated according to the practices and workflows proposed by the EASME, under the form of 7-day packages. Both services target SMEs having a growth and internationalization potential. They will also get the chance to join the community of European SMEs having benefited from these services. KAMWAL 2.1 has as objective to serve 40 Walloon SMEs during the project by dedicating well-skilled and experienced consultants who will participate into training and networking activities gathering experts from this specialized part of the network.

Keywords: innovation,internationalisation,sme instrument,innovation management,enterprise europe network,wallonia
Representing Idiocy and Intellectual Disability in Early Modern English Literature, 1500-1640 (Renaissance Idiocy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-11-01
End date: 2019-10-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

My project will consider several examples of natural or artificial fools, clowns, idiots portrayed in the literary production of England from 1500 to 1640 and will investigate how early modern notions of intellectual deficiency primarily in medicine but also in society shaped the creation of those same figures. My literary corpus will include not only dramatic texts but also jestbooks, which notably offer a wealth of information on real or fantastic fools of the time, and poetical works. Folly in the sense of lack of wit, rather than the loss of it – which is the definition of madness – will be my primary focus. While the theme of madness in connection with early modern literature has been explored at length, the same cannot be said for cognitive disability or lack of intelligence. The main reason for this is that only recently have a small number of scholars started to discuss and bring together historical, medical and legal notions of natural folly in the early modern period. In the past, remarkable attempts at historicizing natural folly have bordered into discourses on madness and analogue mental disorders thus blurring the difference between the two conditions, the same difference that Renaissance legislation actually sought to define. In the wake of very recent trends in disability studies, therefore, I will use legal but especially medical theories of foolishness and idiocy to explore the characters of my corpus and to highlight, on a scientific and social basis, their separate nature from those conceived of as lunatics. Furthermore, because the exploration of intellectual disability in my period of interest is relatively a new field, I expect to find in the fools of my corpus hints to theories or assumptions that have not been discussed yet.

Keywords: idiocy,intellectual disability,intelligence,natural fools,clown,folly,renaissance,early modern,drama,jestbooks,medical humanities,madness,galen,shakespeare,robert armin