Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Addressing key uncertainties in mineral DUST EmiSsion modelling to better constrain the global dust cycle (DUST.ES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Mineral dust emission is ubiquitous in arid and semi-arid areas, representing a serious hazard for health, environment, and economy in many countries, in particular some of the least developed. Dust is a dominant contributor to the global aerosol load and plays a significant role in different aspects of climate and atmospheric chemistry. A key uncertainty in estimating present-day dust emissions is the contribution of human activities such as cultivation and grazing that disturb the soil. Recent research allowed representing natural and anthropogenic dust sources in global models based on high-resolution satellite data and land use maps. However, the accurate quantification of dust emissions and their attribution to natural and anthropogenic origin is currently hampered by deficiencies in dust emission modelling. Deficiencies include an incomplete representation of the physics of dust emission and a lack of skill to model certain atmospheric processes driving dust emission. DUST.ES will constrain present-day global dust emissions for both source types (natural/anthropogenic) taking into account (1) aerodynamic entrainment, a potentially important, yet previously neglected dust emission mechanism; and (2) moist convective dust storms (haboobs), intense dust events, which are unrepresented in global models, but have a big impact on society. DUST.ES will estimate the regional and global relative significance of dust emissions caused by different dust emission mechanisms, meteorological dust injection processes, and source type. Results of DUST.ES will be a cornerstone to the longer-term goal of quantifying the effects of anthropogenic dust sources in the present and future climate. The beneficiary (BSC) hosts the WMO Dust Storm Prediction Regional Center for North Africa, Middle East and Europe, ensuring that the results have an immediate and sizeable benefit in several areas of public and private sectors across Europe and beyond.

Keywords: dust emission,haboobs,dust sources,dust modelling,global modelling
Methods and tools for GDPR compliance through Privacy and Data Protection Engineering (PDP4E)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Ensure privacy and freedom, including in the Internet and enhance the societal, legal and ethical understanding of all areas of security, risk and management
Action type: Innovation actions
Partnership: Cybersecurity PPP (cPPP)
Countries involved: Germany,Spain,Spain,Spain,Germany,Belgium,France
Call: Cybersecurity PPP: Privacy, Data Protection, Digital Identities (H2020-DS-SC7-2017, 2017)
Start date: 2018-05-01
End date: 2021-04-30
Duration (months): 36.0
Total project cost (EUR): 3362457.22
EU funding (EUR): 2941113.13
Participants: 10
Project status: CLOSED

PDP4E is an innovation action that will provide software and system engineers with methods and software tools to systematically apply data protection principles in the projects they carry out, so that the products they create comply with the General Data Protection Regulation (GDPR), thus bringing the principles of Privacy and Data Protection by Design to practice. PDP4E will integrate privacy and data protection engineering functionalities into existent, mainstream software tools that are already in use by engineers, focusing on open-source tools that will be integrated in the Eclipse ecosystem, The approach will integrate methods proposed by the privacy engineering community (e.g. LINDDUN, ISO/IEC 27550 Privacy engineering), and the industry of software and system engineering tools (e.g. MUSE, PAPYRUS or OpenCert) using a model driven engineering approach. PDP4E will introduce privacy and data protection into software and system engineering disciplines (Risk Management, Requirements Engineering, Model-Driven Design, and Assurance), which drive the everyday activities of engineers. Results of PDP4E will be assessed by two demonstration pilots on industries where privacy and data protection are especially relevant, one on C-ITS applications and services (connected vehicle application domain) and one on big data on smart grid (smart grid application domain). PDP4E will promote its results in engineering communities, as Eclipse (community of software developers) or IPEN (community of stakeholders with an interest on privacy engineering). An open Alliance for Privacy and Data Protection Engineering is planned as a follow-up of the project, building on that community and the synergies among partners. PDP4E includes 8 partners and has a 36-month duration.

Keywords: privacy by design,privacy data protection,privacy engineering,gdpr compliance,methods,tools,meta model driven
An innovative 3D Free-form manufacturing technology for the construction industry (i-Contour)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-11-01
End date: 2019-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Freeform surfaces play a prominent role in contemporary architecture. However current methods used in the construction industry to produce free-forms involve five major problems. 1. Since they do not involve machine production, the accuracy according to the CAD model is limited and the architect has no direct control on end product. 2. Manually built structures, with two opposing wire mesh frames, with interposed plastic wool often suffer corrosion. This restricts their inclusion in buildings. 3. Due to weight and size of prefabricated free-forms, transportation is difficult and expensive. 4. High manpower demand: at least 3 persons must work on the mounting of each structure. 5. Milling of moulding causes 50% waste. Clever Contour, an Austrian company founded in 2013, is finishing the development of i-Contour, an innovative technology to design and produce large 3D free-forms at 90% lower cost and overcoming key technical barriers such as high weight and transportation difficulties. i-Contour is the first end-to-end manufacture technology for free-forms thanks to two key elements: an own-developed frontend software – a plug-in for Rhinoceros, and an innovative 3D bending machine for plastics. The most relevant Unique Selling Points of i-Contour are: *drastic costs reduction (up to 90%), *real-time control of the overall process, *weight reduction (up to 50%), *easiness of transportation and mounting, and *very fast production time (from weeks down to 2-3 days). The first prototype of the system is already working in our premises and we have successfully executed 6 projects with national and international design studios. We have also engaged several companies from different segments such as concrete manufacturers, formwork producers and architects. By the end of 2023, three years after market launch, we expect to have an accumulated revenue of €21 million and have created up to 20 new positions.

Keywords: concrete free forms,3d plastic bending machine,rhinoceros plug in,shotcrete
Experimental Aero- and Thermal investigation for a next generation Engine Exit Module (EATEEM)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Sweden
Call: Experimental investigation of aerodynamic and heat transfer properties for a next generation turbine frame and nozzle (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-10-01
End date: 2022-06-30
Duration (months): 45.0
Total project cost (EUR): 799608.75
EU funding (EUR): 799608.75
Participants: 1
Project status: CLOSED

A unique facility for experimental testing of engine exit modules (EEM) at engine-realistic flow conditions is currently available at Chalmers University of Technology and will be used to address this JTP action. The unique design of the facility includes an open test section which permits investigation of the complete EEM assemblies consisting of a turbine rear structure (TRS) and a core exhaust nozzle. The facility is equipped with a 1.5 stage shrouded low-pressure turbine (LPT) providing realistic inflow to the tested EEM. The parameters of the facility completely fulfil the requirements specified in the topic description. Thus, the LPT blade height, the flow Reynolds number range, the LPT flow coefficient, the LPT load coefficient, the LPT exit swirl angle range, the LPT hub-to-tip ratio and the purge flow are as specified. The instrumentation of the facility also completely fulfils the topic requirements. Multi-hole pressure probes are available upstream and downstream of the tested EEM. Both traversing systems are covering an entire 360-degree sector of the test section from hub to shroud. Furthermore, in practically all modern techniques of the flow and heat transfer diagnostics are available in the facility. This includes a complete set of equipment and software for PIV (particle image velocimetry) including high-speed stereo-PIV, tomographic-PIV, long-distance micro-PIV and endoscopic micro-PIV. Furthermore, equipment and software for surface oil-flow visualisation and oil-film interferometry, hot-wire and hot-film interferometry, pressure- and temperature-sensitive paints, digital image correlation (DIC), naphthalene sublimation, liquid-crystal thermography and IR-thermography are available as well. Personnel in the workgroup is highly skilled in using all these measurement techniques and has many years of experience in innovation turbomachinery research programs at national and European level.

Keywords: engine exit module,turbine rear structure,core exhaust nozzle,efficiency improvement
Deciphering the molecular dynamics of centriole and centrosome biogenesis (CENTROMD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-01
End date: 2022-11-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Centrosomes are organelles composed of a pair of centrioles surrounded by a pericentriolar matrix (PCM) that perform a variety of key functions in the animal cell. Centrosomes duplicate precisely once during S-phase of the cell cycle; in G2-phase the two centrosomes move to opposite locations around the nucleus and expand their PCM to nucleate vast quantities of microtubules for mitotic spindle formation. Dysfunctions in the centrosome cycle have been associated with a wide range of pathologies and, in particular, centrosome amplification, an aberrant increase in centrosome numbers, is a hallmark of most human cancers. Centrosomes are complex machines composed of hundreds of proteins, however significant efforts over the past decades have identified the key elements which are essential for centriole and centrosome biogenesis. We can now address the molecular mechanisms that mediate interactions between key players and how these contribute to regulate the number and size of these organelles during the cell cycle. Elucidating these mechanisms is of great interest to cell biology and cancer research. This research proposal aims to investigate aspects of centriole and centrosome biogenesis using Drosophila melanogaster as an animal model. The main objectives are: 1), to reconstitute initial steps of centriole assembly using a hybrid in vivo/in vitro approach, where I will study the molecular dynamics of the interaction between key centriolar proteins Asl and Plk4, using functionalised microspheres as a scaffold and 2), to analyse the dynamic behaviour of single molecules of key centrosomal proteins Cnn and Spd-2 as they move throughout the PCM during expansion, using super-resolution microscopy techniques. We are confident that these studies will provide novel insights into the design principles and inner workings of these important organelles.

Keywords: centriole and centrosome biology,single molecule localization microscopy,super resolution microscopy,in vitro reconstitution of biological systems
Personalized Neurostimulation Approach for the Treatment of Depression (PLATOSCIENCE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-06-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Depression currently affects more than 300 million people worldwide, that is an increase of over 18% between 2005 and 2015. Moreover, 50% of major depressions are untreated in Europe, costing about €170Bn per year. Despite subject´s relevance, there are not any efficient nor customized treatment options, these falling often within conventional solutions (e.g. cognitive techniques), medication or neurostimulation techniques that do not acknowledge an individual rehabilitation for the patient. Platoscience has developed the world’s first plug n’ play device based on trans-cranial direct current neurostimulation (tDCS) for a personalised at-home treatment of depression. The patent-protected device, PlatoCure, consists of a portable neurostimulation headset with two programmable electrodes, easy to use and control, connected to an app to be tracked by health professionals and for cloud data collection and predictive analytics to improve individual treatment. PlatoCure also includes online neuroimaging by electroencephalogram (EEG) that enables measuring of electrophysiological data during stimulation. This yields a significant advantage of PlatoCure against competition, strengthening market introduction to become the standard treatment device for moderate to severe depression, yielding benefits for a large group of stakeholders, including patients, medical professionals, hospitals and clinics. The SME Ph1 will be crucial for: i) establishing partnerships with relevant stakeholders on an international level in the medical segment, ii) setting up a regulatory strategy and iii) developing a clear commercialisation strategy. Hereafter, PlatoScience will be able to start SME Ph 2 focusing on the clinical validation of the device with hospitals and clinics. Until the end of 2026, we expect a cumulative revenue of €10,1 million, gross profit of €8,25 million and to create 15 qualified new jobs, within 5 years of commercialization.

Keywords: depression,neurodisorders,neurostimulation
Raising Innovation Capacity for Innovative Companies from Latvia (2020-2021) (InnoSME-LV-2020-2021)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Latvia
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 52501.25
EU funding (EUR): 52501.0
Participants: 2
Project status: CLOSED

The overall objective of the project is to contribute to smart growth in the European Union by increasing the efficiency and effectiveness of investments in research, development and innovation and by contributing to a better and more efficient connection of actors along the innovation chain. To achieve this objective the following measures are foreseen: • To support SMEs, as the beneficiaries of the SME support instrument to identify bottlenecks to the creation of economic impact in companies benefiting from grants by Horizon 2020 Enhanced European Innovation Council (EIC) pilot and address these bottlenecks with the help of capable coaches; • To increase the efficiency and effectiveness of innovation processes in small and medium sized enterprises with significant innovation activities that could potentially become beneficiaries of European support to research and innovation but would not have effective access to consulting services for innovation management. In practice at least fourteen (14) specialised on average 7-day service packages will be delivered to SMEs to assist them in successful benefiting from Horizon 2020 Enhanced European Innovation Council (EIC) pilot and increase their innovation management capacity beyond this programme. The services addressed by the current proposal will be integrated in already existing Enterprise Europe Network services.

Keywords: sme instrument,key account manager,innovation management capacity,eic pilot
Finding the iron sensing protein in crop plants (FeSensor)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Iron (Fe) is needed for all living organisms but in high concentrations within the cell it is toxic, therefore balancing the physiological level of iron is essential. Although the Fe sensing mechanism has been described for a wide variety of living forms, from bacteria to mammals, no clear information about how plants sense Fe is available. Whether or not Fe is sensed in roots or in shoots or in both, the chemical form of the Fe or the identity of the sensing protein, remains unknown. In yeast and mammals, Fe is sensed via Fe-S proteins, but in plants the Fe sensing mechanism has been shown to be independent from Fe-S cluster assembly in the mitochondria or cytosol. Using comparative transcriptomics in two model plant species I have identified a small family of genes (IRS1, IRS2 and BTS) that are good candidates for the plant Fe sensors. I would like to investigate if their putative Fe binding motifs, haemerythrin and rubredoxin, are functional in an Fe-sensing capacity. Moreover, I will investigate if the proteins have ubiquitination activity as predicted, and tissue-specific expression compatible with a double sensing mechanism in roots and leaves. Other possibilities for the Fe-sensing mechanism will be explored by using mutants defective in Fe-S assembly in the plastids, and unknown candidates will be uncovered with an unbiased mutant screening. Perturbing the Fe sensing mechanism in a tissue-specific manner would be a smart way of increasing the Fe content without causing toxicity symptoms in the rest of the plant.

Keywords: iron,heme,arabidopsis,transcription factor,sensor,homeostasis
The impact of TFIID on the transcription initiation machinery – a structural perspective. (POL2-TFIID)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Transcription is a first step of gene expression, a process by which a functional gene product is synthesized based on genetic information from DNA. Gene expression is tightly regulated with complex mechanisms that give cells the flexibility to adapt to a variable environment. Defects in regulation and transcription mechanisms leads to serious pathologies in cells and organisms, that in humans includes cancer development, autoimmunity and neurological disorders, cardiovascular diseases etc. Structural studies of transcription in the last two decades, brought priceless insight into the mechanisms involved in the process, especially concerning transcription initiation. The next step in understanding gene expression is to combine knowledge about gene regulation with the mechanisms of transcription initiation. I will investigate the molecular basis of gene regulation and transcription initiation interplay using strategy that combine state-of-the-art cryo-electron microscopy, chemical cross-linking, mass-spectrometry and biochemical assays.

Keywords: gene transcription,pre initiation complex,tfiid structure
EU-STRAT - The EU and Eastern Partnership Countries: An Inside-Out Analysis and Strategic Assessment (EU-STRAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Research and Innovation actions
Countries involved: Ukraine,Germany,Switzerland,Lithuania,Moldova, Republic of,Poland,Belarus,France,Netherlands,United Kingdom
Call: The European Union and the Eastern Partnership (H2020-INT-SOCIETY-2015, 2015)
Start date: 2016-05-01
End date: 2019-04-30
Duration (months): 36.0
Total project cost (EUR): 2665138.75
EU funding (EUR): 2292221.75
Participants: 11
Project status: CLOSED

Ten years after its inception, the European Neighbourhood Policy (ENP) has fallen short of accomplishing its mission. The war in Ukraine and the rising tensions with Russia have made a re-assessment of the ENP both more urgent and more challenging. EU-STRAT will address two questions: First, why has the EU fallen short of creating peace, prosperity and stability in its Eastern neighbourhood? Second, what can be done to strengthen the EU’s transformative power in supporting political and economic change in the six Eastern Partnership (EaP) countries? Adopting an inside-out perspective on the challenges of transformation the EaP countries and the EU face, EU-STRAT will • develop a conceptual framework for the varieties of social orders in EaP countries to explain the propensity of domestic actors to engage in change; • investigate how bilateral, regional and global interdependencies shape the scope of action and the preferences of domestic actors in the EaP countries; • de-centre the EU by studying the role of selected member states and other external actors active in the region; • evaluate the effectiveness of the Association Agreements and alternative EU instruments, including scientific cooperation, in supporting change in the EaP countries; • analyse normative discourses used by the EU and Russia to enhance their influence over the shared neighbourhood. • formulate policy recommendations to strengthen the EU’s capacity to support change in the EaP countries by advancing different scenarios for developmental pathways. EU-STRAT features an eleven-partner consortium including six universities, three think-tanks, one civil society organization and one consultancy. This consortium will achieve the research and policy relevant objectives of the project by bringing together various disciplinary perspectives and methodologies and strengthening links with academics and policy makers across six EU member states, Switzerland and three of the EaP countries.

Keywords: european neighbourhood policy,eastern partnership,post soviet transition,interdependence,discourse,scientific cooperation