Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Yeast cell factory for mRNA bioproduction (Yscript)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,Portugal,Germany,Poland,Slovenia
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-04-01
End date: 2025-09-30
Duration (months): 42.0
Total project cost (EUR): 3079675.0
EU funding (EUR): 3078249.75
Participants: 11
Project status: SIGNED

Messenger RNA (mRNA) vaccines have become a game-changer in the fight against COVID-19, providing an exit strategy to the global crisis of our age. mRNA is now considered a promising biopharmaceutical for a vast array of medical applications. Currently, in vitro transcription (IVT) is the only available technology for mRNA production; however, it relies on a complex supply chain and costly purification process. Reliable large-scale IVT production is challenging and high production costs are an issue for low-income countries, and this will be even more critical for clinical mRNA applications requiring high doses. Yscript’s groundbreaking nature lies in the generation of a specific mRNA bioproduction process in yeast, integrating innovative extraction and purification processes, representing a complete shift of paradigm compared to IVT production and a revolutionary new use of yeast. Although yeast possesses a similar mature mRNA structure as humans and is recognized as safe for pharmaceutical production, mRNA bioproduction and isolation have never been attempted. Yscript will provide groundbreaking technological improvements by: i) decreasing the mRNA production supply chain; ii) increasing the purity yield of long mRNA by avoiding premature termination occurring during IVT; and iii) guarantying mRNA stability through integrated extraction-purification processes. This will ensure the generation of high-quality mRNA therapeutics, while streamlining production and reducing costs. Yscript brings together world-class expertise in molecular biology, biophysics, biotechnology, chemistry, chemical engineering, mRNA therapeutics, yeast Ty biology, bioproduction and purification processes. The project will significantly advance the current state of the art of mRNA manufacturing. Yscript will foster citizens’ well-being and health, while decreasing economic and social disparities associated with biopharmaceutical-based therapies, in which mRNA is nowadays a key element.

Keywords: non immunogenic mrna or messenger rna,genome engineering,process engineering,bioproduction,yeast cell factory,ty retrotransposon,purification,ionics liquids,clarification
IMDEA Nanociencia Doctoral Training Programme in Nanoscience (IDEAL PhD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,United Kingdom,Denmark,France
Call: MSCA COFUND 2021 (HORIZON-MSCA-2021-COFUND-01, 2021)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1411200.0
EU funding (EUR): 1411200.0
Participants: 8
Project status: SIGNED

IDEAL PhD programme is a new doctoral fellowship programme promoted by Fundación IMDEA Nanociencia (IMDEA Nano) that aims to attract 12 talented researchers in two open calls to undertake excellent research in any of the programmes at the Institute: P1 Nanotechnology for energy harvesting, P2 Quantum materials at the nanoscale, P3 Nanotechnology for healthcare, P4 Nanomagnetism for Information and Communication Technologies, P5 Ultrafast phenomena at the nanoscale and P6 Sustainable nanotechnologies and critical raw materials. The research programmes are supported by a Platform for Disruptive Innovation which encourages links with industry to help achieve translation of results to market provide support and facilities for prototyping, proof-of-concept testing, and scaling-up. They will be offered secondments of 3-6 months at Partner Organisations relevant to their research careers both academic and non-academic, depending on preference. Within the IDEAL PhD programme, we aim to boost the careers of talented researchers offering them an innovative, truly interdisciplinary and inter-sectoral training in nanoscience and nanotechnology. IMDEA Nano is committed to providing a pool of researchers with the skills and knowledge needed to tackle the next challenges in the nanoscience field. Doctoral candidates will receive a well-balanced research independence and mentoring from an experienced scientific and management team as well as access to an infrastructure of the highest level for the pursuit of their projects in nanoscience and nanotechnology. Fundación IMDEA Nanociencia is a non-profit Foundation created in 2006 jointly by the regional government of Madrid and the government of Spain to shorten the distance between research and society; providing new capacity for research, technological development and innovation in the field of Nanoscience and Nanotechnology.

Keywords: nanoscience,nanotechnology,disruptive innovation,interdisciplinary,inter sectoral
Deep Reinforcement Learning-Based Battery Management System for Electric Vehicles (DeepBMS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-15
End date: 2025-03-14
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: CLOSED

Battery Management System (BMS) plays a pivotal role in monitoring, control, and protecting the Electric Vehicle (EV) Lithium-ion battery packs. In vehicular applications, batteries are usually subjected to harsh operating cycles and varying environmental conditions leading to very complicated interactions of different aging factors and unforeseeable modeling uncertainties. Therefore, the classical model-based techniques cannot completely handle the foregoing factors, which always leave an unwanted state estimation error in the BMS. This project intends to apply a multidisciplinary approach by combining the advantages of deep reinforcement learning and classical model-based techniques to improve the BMS functionality in EVs. Specifically, DeepBMS aims to: 1-Develop efficient deep reinforcement learning-based algorithms which are able to capture the convoluted time-varying behavior of battery and can gradually improve themselves by learning in real-time 2- Combine the beneficial features of model-based and data-driven techniques to improve the state estimation accuracy in a wide temperature range and over the full life span of the batteries, thereby increasing the reliability and extending the battery lifetime. The interdisciplinary nature of DeepBMS is very strong, involving a combination of control and state estimation theory, power electronics, battery storage systems, and machine learning. The supervisor and candidate have excellent complemental research experiences in these fields providing the necessary competencies to bring the project to successful completion. The project ensures two-way transfer of knowledge including training of the candidate in cutting-edge advanced techniques in a state-of-the-art laboratory, which improves his future career prospects. Likewise, DeepBMS is in line with the EU strategic action plan on batteries and its results have a great potential to be further developed at the fundamental and applied levels through follow-up research.

Keywords: batteries,state estimation,battery management system
An integrated experimental and mathematical approach to investigating endothelial barrier integrity in health and cerebral malaria (CMEndoMod)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

The integrity of the endothelial barrier is vital for maintaining healthy brain function and is especially compromised in pathological conditions such as cerebral malaria. Despite its significance, the current understanding of the mechano-chemical mechanisms operating at sub-cellular, inter-cellular, and tissue scales within endothelial barriers during cerebral malaria remains limited. This project aims to close this knowledge gap by integrating advanced in vitro experimental methods with multi-scale mathematical models. Through a multi-tiered methodology—including single-cell assays, 2D endothelial monolayer cultures, and 3D brain microfluidic devices—we plan to assemble a comprehensive dataset that captures the complex mechano-chemical processes underlying endothelial function and dysfunction. This rich dataset will facilitate the data-driven development, calibration, and validation of a new multi-scale mathematical model, along with a high-performance computational framework for its solution. The validated models will subsequently be used to design targeted experiments aimed at dissecting the molecular mechanisms regulating endothelial integrity. Our interdisciplinary approach is uniquely poised to cultivate a dynamic interplay between experimental data and mathematical modelling, leading to a more holistic understanding of the mechanisms responsible for endothelial integrity in healthy states and how they are compromised in the cerebral malaria condition. Ultimately, this strategy aims to provide an in-depth understanding of the endothelium, which could, in the long term, aid in the development of therapeutic interventions for cerebral malaria.

Keywords: endothelial cell,parasite,cerebral malaria,microfluids,mathematical modelling,finite element
The unusual role of a highly divergent Arp2/3 complex in the mosquito stages of malaria parasites. (PlasmoArp)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1499527.0
EU funding (EUR): 1499527.0
Participants: 1
Project status: SIGNED

The malaria-causing Plasmodium parasites often use highly divergent proteins to regulate fundamental biological processes, such as sexual replication in the mosquito. Therefore, the molecular and cellular biology underlying parasite development is often little understood, especially during the mosquito stages, a major bottleneck in the Plasmodium life cycle. Recently, I identified an unconventional, Plasmodium-specific actin-related protein 2/3 (Arp2/3) complex that mediates DNA segregation during male gamete formation and is essential for development of the main replicative mosquito stage, the oocyst. Understanding the regulation and function of this structurally and functionally divergent actin nucleator could provide targets for new antimalarial strategies. Here, I propose to elucidate the molecular mechanism of the Plasmodium Arp2/3 complex on three levels: (1) I will uncover how Arp2/3 is activated during gamete formation, revealing the likely unusual mode of regulation of this complex. (2) I will explore the hypothesis that Arp2/3 is linked to a cryptic spindle assembly checkpoint, a mitosis regulator so far thought to be absent in Plasmodium. (3) I will reveal why Arp2/3-deficient parasites arrest in oocysts, which will shed light on the unusual cell division mode of this elusive stage. To address these ambitious aims, I will combine molecular biology methods, single cell transcriptomics and imaging, and I will engineer a new genetic tool to dissect gene function specifically in the oocyst, a stage that is notoriously difficult to study. PlasmoArp will thus not only give insight into the molecular biology of Plasmodium development in the mosquito and advance our understanding of Arp2/3 and actin biology across the eukaryotic kingdom, but it will also expand the toolbox to study the neglected oocyst. As Plasmodium Arp2/3 is essential for malaria transmission, this research will pave the way for new intervention strategies to mitigate malaria infections.

Keywords: plasmodium mosquito stages gametogenesis mitotic dna segregation actin related protein 2 3 complex
Next-generation weather intelligence for more accurate decision making throughout the economy (SKYFORA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Finland
Call: EIC Accelerator Challenge: Technologies for Open Strategic Autonomy (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-02-01
End date: 2025-07-31
Duration (months): 30.0
Total project cost (EUR): 3569373.75
EU funding (EUR): 2498561.63
Participants: 1
Project status: CLOSED

In light of climate change, people around the world must increasingly cope with unexpected and unfavourable weather conditions with significant impact on the proper functioning of societies. Although significant work is done to mitigate climate change, it is inevitable that reversing the course will take time. Meanwhile, it is essential to adapt to the new reality and the key to this is better understanding of weather. For this purpose, Skyfora is developing a ground-breaking innovation that is the first to provide accurate and detailed weather information in 3D derived from GNSS signal delay data. This technology enables real-time measurement of the most important weather parameters around the globe, instead of certain measured locations. As a result, the threats of extreme weather phenomena (storms, floods, snowstorms, heatwaves etc) can be continuously monitored and timely measures can be taken to save lives and mitigate economic disruptions and financial risks.

Keywords: gnss technology,artificial intelligence,weather forecasting
Arcs of Time: Zoroastrian Philosophical Anthropology (AOT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 3
Project status: SIGNED

The project “Arcs of Time: Zoroastrian philosophical anthropology” (AOT) explores a new area of Zoroastrian thought by combining philological and philosophical methodologies to a more holistic understanding of the textual sources. Zoroastrian philosophical anthropology analyses the person as an historical composite, whose spiritual and material parts change over time. So, the AOT project analyses both the historical part of this theory, including debates on the origin of humanity and on the cyclical nature of human history, and it also analyses the constitutive part, including debates on psychophysical composition and on human wisdom. Its objective is to produce philosophically precise translations of 40 chapters from Dēnkard III that exhaust both parts of Zoroastrian philosophical anthropology. Dēnkard III is a medieval encyclopedia of Zoroastrian thought, and it is preserved in a single problematic manuscript. Contemporary scholars are now turning their attention to the Dēnkard. The method is a philosophically-informed philology. It will first produce critical editions from the problematic manuscript, and adduce linguistic parallels within the wider Zoroastrian literature from this period in order to ensure philological accuracy. It will second produce a rational reconstruction of the philosophical worldview expressed in the texts, and adduce conceptual parallels within both the Zoroastrian literature and the literature in Arabic contemporary to the authors of the Dēnkard in order to ensure philosophical accuracy. The philological work will be uploaded to an open-access online database for scholarly collaboration and for the general public; the philosophical work will result in two open-access articles meant to explain the technical details of the translations to audiences not specialized in the Dēnkard or Zoroastrian thought.

Keywords: zoroastrianism,iran,islamic studies,religion,philosophy,
BATTERY Management system and System design for stationary energy storage with 2nd LIFE batteries (Battery2Life)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Greece,Spain,Austria,Estonia,Switzerland
Call: Battery management system (BMS) and battery system design for stationary energy storage systems (ESS) to improve interoperability and facilitate the integration of second life batteries (Batt4EU Partnership) (HORIZON-CL5-2023-D2-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 4791618.49
EU funding (EUR): 4008064.66
Participants: 11
Project status: SIGNED

Battery2Life will facilitate the smooth transition of batteries to 2nd life use and boost the innovation of the European Battery Industry by providing enablers to implement open adaptable smart BMSes and improved system designs and proposing methods for the efficient and reliable reconfiguration of used batteries. Battery2Life introduces two new battery system design frameworks serving the upcoming market needs: the first supports the business transition for the initial market by restructuring existing battery design patterns while the second one introduces completely new design principles for 1st and 2nd life of the battery. A completely new BMS design mentality is introduced to the battery industry by delivering an open and interoperable hybrid BMS architecture (with an Embedded and a Cloud section) leading the transition from technology-driven BMS designs, to serve the needs of specific applications and battery technologies, to new data-driven and application-agnostic BMS designs, that can be easily adapted and updated to serve the requirements of different battery technologies and any 2nd life battery stationary storage application. Furthermore, Battery2Life introduces innovative embedded sensing and more accurate SOX estimation algorithms, new SOX indicators appropriate for 2nd life use -i.e. SOS (safety) and SOW (warranty) - and a new EIS implementation approach by integrating it in the BMS, that will enable the detailed safety and reliability monitoring at both cell and module level during 1st and 2nd life usage. The project will specify an open BMS concept, data formats, taking into account and extending the battery passport concept, and interoperable communication via the cloud platform to third parties including the future passport exchange system, to facilitate monitoring and assessment. The project prototypes will be demonstrated within the context of two business cases, i.e. domestic storage application and utility-scale load levelling one.

Keywords: 2nd life battery applications,battery management system,system design,open architecture,battery digital passport,smart sensors,sox estimators,electrochemical impedance spectroscopy
Renewing the World: A Philosophical History of Early Modern Ecology (NEWWORLD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1999663.0
EU funding (EUR): 1999663.0
Participants: 1
Project status: SIGNED

This project undertakes the first comprehensive investigation of early modern ecology. NEWWORLD counters the standard historiographical argument that ecological concern is a recent phenomenon. A key element in that claim is the assumption that the terminology of environmental care is recent: the term 'ecology' was invented in the 19th century by Ernst Haeckel; 'sustainability' is a 20th-century coinage; 'the environment' was used for the first time in English by Thomas Carlyle in 1827. Yet, these terms that now help to define ecological sensibilities arose from long-lasting debates. The leading claim of this project is that early modernity was a particularly fertile period for ecological reflection. NEWWORLD proposes an innovative methodology to capture the breadth and philosophical substance of early modern ecological debates: it proceeds from present-day terms to construct terminological and conceptual constellations in early modern texts. It uses a technique that historians (of philosophy) label 'controlled anachronism', and which this project aims to fully exploit for the first time on a large scale. The objectives, subdivided into the four main areas 'Environment', 'Pollution', 'Sustainability', and 'Ecological Justice', involve tracing a symbiotic connection between metaphysical, natural-philosophical, religious, and ethical ideas. NEWWORLD will both reveal the specificities of early modern thought on ecological matters, and pioneer a dialogue with ecological debates as we know them today. The project's main output will be a multi-volume philosophical history of environmental care in the early modern period. This will be complemented by the curation of an exhibition, featuring 3D models of cosmographical images and projections of early modern plans for ideal cities, showing them to be laboratories of ecological views. NEWWORLD seeks to offer a new paradigm for the intervention of the history of philosophy in present-day debates on ecology, and beyond.

Keywords: early modern philosophy,ecology,sustainability,pollution,ecological justice,utopia,controlled anachronisms