Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Lifting Methods for Global Matching Problems (LiftMatch)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-03-01
End date: 2023-02-28
Duration (months): 60.0
Total project cost (EUR): 1675640.0
EU funding (EUR): 1675640.0
Participants: 1
Project status: TERMINATED

This proposal presents a research program aimed at breaking new ground in theoretical, algorithmic and practical aspects of the notoriously difficult matching problems. The main goal is developing a unified algorithmic framework for matching problems that enjoys theoretical guarantees and high practical value for ``real-life'' applications. The core methodological aspect is the modelling of matching problems as high-dimensional, lifted convex problems that can be efficiently approximated. We present several case-studies of this methodology, constructing efficient algorithms for approximating the solutions of important instances of the matching problem. The results already demonstrate state of the art performance and are backed-up with novel theoretical analysis proving tightness and correctness of the suggested convexifications for certain classes of non-trivial input. This proposal has ``high risk - high impact'' profile: The ``high-risk" aspect of this proposal comes from the hardness of general matching problems which, when faithfully represented, are NP-hard. However, as we demonstrate, combining convex optimization tools in a careful way, that takes into account computational complexity, is likely to push forward the limits of current algorithmic solutions. The ``High-impact" will be immediate: As matching problems exist in almost every aspect of scientific research, practical generic algorithms for matching problems are likely to have a significant influence. We believe that the inroads and preliminary results presented in this proposal already provide strong evidence for the potential success of the suggested research program.

Keywords: shape matching,non rigid matching,geometry processing,shape analysis
Novel Blueprints for the Visible-Light-Mediated Assembly of C–N Bonds via Nitrogen Radicals (NEBULAR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany,United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-10-31
Duration (months): 70.0
Total project cost (EUR): 1494777.0
EU funding (EUR): 507428.56
Participants: 2
Project status: SIGNED

Nitrogen-containing compounds underpin every aspect of our daily life as they form the structural basis of almost all pharmaceuticals, agrochemicals, food additives and materials. The invention of methods for the formation of bonds between C and N atoms is of strategic importance for the discovery and evolution of molecules with direct implications on the quality of our lives. Despite this fundamental relevance, forming C–N bonds is still a very challenging task. This proposal aims to deliver transformative advances for the development of new efficient and selective strategies for the synthesis of N-containing molecules by harnessing visible-light as inexpensive and sustainable source of energy. I aim to challenge preconceptions about the field of organic chemistry and to develop innovative methods to control, modulate and transform the reactivity of nitrogen-centered radicals (NCRs), an entire class of reactive intermediates for which there are only limited applications in modern organic chemistry. My research group has developed two novel visible-light-mediated ways of generating NCRs, and I aim to: (1) Harness and explore the unique features of visible-light-mediated transformations to provide novel multicomponent reactions of NCRs. (2) Establish NCRs as viable partners in asymmetric photoredox catalysis and use them for the easy construction of complex molecules with defined 3D shapes. (3) Merge the visible-light generation of NCRs with organocatalysis to enable novel dual catalytic asymmetric protocols. (4) Combine the NCRs with transition metal catalysis and discover unprecedented transformations that go beyond photoredox catalysis and transition metal catalysis alone. This cohesive and innovative approach will develop new tools essential for the assembly of complex molecules with biological, therapeutic and agrochemical properties. Overall this project will transform the way C–N bonds are forged and how N-containing molecules are assembled.

Keywords: photoredox catalysis,visible light,electron tranfer,nitrogen containing molecules,c n bond formation
Engineering Topological Phases and Excitations in Nanostructures with Interactions (ETOPEX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 1158403.0
EU funding (EUR): 1158403.0
Participants: 1
Project status: SIGNED

The main goal of this theory project is to propose engineered topological phases emerging only in strongly interacting systems and to identify the most feasible systems for experimental implementation. First, we will focus on setups hosting topological states localized at domain walls in one-dimensional channels such as parafermions, which are a new class of non-Abelian anyons and most promising candidates for topological quantum computing schemes. Second, in the framework of weakly coupled wires and planes, we will develop schemes for novel fractional topological phases in two- and three-dimensional interacting systems. To achieve these two goals, my team will identify necessary ingredients such as strong electron-electron interactions, helical magnetic order, or crossed Andreev proximity-induced superconductivity and address each of them separately. Later, we combine them to lead us to the desired topological phases and states. On our way to the main goal, as test cases, we will also study non-interacting analogies of the proposed effects such as Majorana fermions and integer topological insulators and pay close attention to the rapid experimental progress to come up with the most feasible proposals. We will study transport properties, scanning tunneling and atomic force microscopy. Especially for systems driven out of equilibrium, we will develop a Floquet-Luttinger liquid technique. We will explore the stability of engineered topological phases, error rates of topological qubits based on them, and computation schemes allowing for a set of universal qubit gates. We will strive to find a reasonable balance between topological stability and experimental feasibility of setups. Our main theoretical tools are Luttinger liquid techniques (bosonization and renormalization group), Green functions, Floquet formalism, and numerical simulations in non-interacting test models.

Keywords: majorana fermions,parafermions,and other topological phases topological qubits nanowires spin obit interaction fractional topological phases superconductivity crossed andreev processes
A KEY TO THE RATIONAL DESIGN OF EXTRACELLULAR VESICLES-MIMICKING NANOPARTICLES (MIMIC-KeY)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Switzerland,Netherlands,Netherlands,United Kingdom
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-06-01
End date: 2025-05-31
Duration (months): 48.0
Total project cost (EUR): 2902527.5
EU funding (EUR): 2902527.5
Participants: 7
Project status: SIGNED

The MIMIC-KEY project proposes to study extracellular vesicles (EVs) to understand their targeting behavior and cargo delivery in natural systems. Such comprehension will be used to build up new artificial materials that have the same targeting capabilities, but are much more scalable and mono disperse of the natural EVs. The MIMICK-KEY concept is to learn from tumor-derived EVs and from their ability to recognize and target tissue-specific features during metastasis. Thus, cancer is not the disease to treat but a source of inspiration to build artificial nanomaterials that mimic the EVs and enable them to fight other clinically unmet diseases, specifically metabolic bone disorders. To achieve this ambitious goal, two main steps are required: 1) Deep understanding of the key molecular features enabling EVs for specific targeting and cargo release to the recipient cells. This will be achieved thanks to a synergistic combination of groundbreaking and multidisciplinary approaches (correlative flow cytometry and super-resolution imaging, biological proteomic profiling, multiscale simulations) of an excellent partnership throughout Europe. 2) Synthetically build artificial EV-mimics towards a clinically relevant formulation. The new EV-mimics will be core-shell structures coated by a mobile, dynamic lipid bilayer shell incorporating key-functional proteins for targeting, enabling a novel enzyme-based therapy against metabolic disease that will be tested in vitro and in vivo. The breakthrough idea of artificial EV-mimics, using only essential building blocks and amplifying their therapeutic functions, will overcome the current limitations of natural EVs and represent a challenge at the frontiers of research. MIMICK-KEY is a high-risk proposal that if successful can lead to a completely new way to conceive bio-inspired mimetic nanoparticles and their functions, impacting on a plethora of applications, primarily the pharmaceutical industry and theranostic nanomedicine field

Keywords: extracellular vesicles,supramolecular chemistry,cell targeting,metabolic bone disease,drug delivery,bioconjugation
Maximizing the Therapeutic Potential of Music through Tailored Therapy with Physiological Feedback in Cardiovascular Disease (HEART.FM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: France,France,United Kingdom,United Kingdom
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2020-11-01
End date: 2023-05-31
Duration (months): 31.0
Total project cost (EUR): 153550.71
EU funding (EUR): 17677.94
Participants: 4
Project status: SIGNED

Cardiovascular disease is the world’s leading cause of death, and hypertension is its foremost medical risk factor. Reducing blood pressure in hypertensive patients has positive cardiovascular effects, and music listening offers non-pharmacological ways to regulate heart rate and blood pressure. Presently, the most effective way to administer music inventions with long-lasting effects is labor-intensive and relies on professional therapists’ intuitions, making it non-scalable to large cohorts. HEART.FM is an app-creation initiative to democratize access to personalized music medicine interventions, informed by physiological feedback. Current music therapy apps fail to address the subjectivity and specificity inherent in individual music response; a gap further exists between music therapy apps and physiological feedback. By leveraging advances in wearable ECG monitors and portable blood pressure sensors, HEART.FM will offer music therapy based on individual users’ physiological feedback around musical change points and transitions, which correspond to emotionally salient moments in music listening. HEART.FM exploits the music structure knowledge and cross-modal music-physiology analysis methods developed and trialed in the ERC project COSMOS to advance the state of the art by linking physiological feedback with computational music structure analysis to provide personalized music listening therapy to achieve targeted autonomic nervous system responses. A development goal will be to make HEART.FM ready for large-scale deployment in randomized, controlled research trials that can establish music-hypertension cause-effect relationships for healthy individuals as well as hypertensive patients. HEART.FM will benefit the research community by offering a crowdsourced portal for collecting research data in cardiovascular disease and music-based preventative therapies. The PoC will explore commercialization and market solutions in both music and medical sectors.

Keywords: personalized music medicine,computational music structure analysis,software system,hypertensive heart disease
Share Knowledge for Effective Management of Aviation Safety (SKEMAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2014-11-01
End date: 2015-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In aviation, experience has shown that accidents are often preceded by safety-related incidents and occurrences revealing hazards at technological level, human factors and organisational deficiencies, but solely reactive interventions have limited efficacy. Existing legislative acts of the Union impose obligations on organizations involved in aviation activities to establish occurrence-reporting systems in the context of their Safety Management System supporting the performance of safety and risk assessment evaluations, utilising appropriate methods and techniques, coupled with specific information about an organization. The implementation of occurrence reporting should be proportionate to the size of an organization and the scope of its activity. However, the community of SMEs active in Europe in Aviation face serious issues both of data availability and specific methodologies, due to the fact that they experience only very few occurrences and events per year and are not very familiar with practical implementation of risk assessment approaches. Consequently, they need data, information about incidents and abnormal occurrences, as well as useful correlations for hazards analysis. This project aims at offering the possibility for SMEs to Share Knowledge for Effective Management of Aviation Safety (SKEMAS). The SKEMAS tool will enable SMEs both to fully comply with existing regulation and to enrich their usually scarce data sets in view for more complete and more realistic safety analysis. The generation of a shared database of methods for risk analysis and real data on occurrences and events will represent a substantial source of information and data shared amongst the various contributors, enabling to carry out valuable statistical analysis and risk assessment. Moreover, in strict compliance with the most recent EU regulations, such a database should ensure full protection from improper use of the data, de–identification of the sources and maximum confidentiality.

Keywords: safety,database,aviation,risk,risk management
Upscaling Synthesis of Ordered mesoporous silica material for Drug delivery Applications (USODA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Belgium
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

FORMAC Pharmaceuticals NV is actively developing and commercialising an innovative and proprietary drug delivery technology to increase the oral bioavailability of poorly aqueous soluble drugs. Those molecules represent up to seventy percent of the compounds in discovery pipelines and up to forty percent of the currently marketed drugs. Based on the use of Ordered Mesoporous Silica (OMS) materials, FORMAC’s platform enables clients’ molecules to be formulated as oral drug products for early development, life cycle management or generic development. FORMAC is key leader in this emerging field with more than twenty different collaboration agreements and fifty molecules tested. Together with its validation in a human clinical setting, numerous regulatory consultations on EU level have been conducted. FORMAC is now ready to secure its first licensing deal with a pharmaceutical or generic company. However, some remaining challenges are hampering full deployment of FORMAC’s technology platform. Given its development stage, the company is still facing (i) an unfavourable cost of goods profile linked to the current OMS synthesis process and (ii) its limited manufacturing scale. The current proposal will unlock the first limitation and create possibilities for further upscaling. FORMAC’s ultimate goal is to bring OMS based drug delivery to the global market.

Keywords: silica,mesoporous,scale up,drug delivery,supply chain,cost of goods,drug development,pharmacy
Fast Acting Virus Control Strategies for Production Animal Diseases (FACTs)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Belgium
Call: SME boosting biotechnology-based industrial processes driving competitiveness and sustainability (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The objective of the FACTs project is to sign a term sheet with investors for ViroVet, an emerging Belgian biotech company, aimed at developing and introducing a disruptive treatment for bovine viral diarrhoea (BVD) in beef cattle. BVD is a globally endemic disease of cattle costing the industry billions of Euros every year in the form of increased mortality, decreased feed efficiency and increased susceptibility to secondary disease. Conventional BVD vaccines are unable to fully control the disease due to antigenic variability of the virus and inadequate host immune response to vaccination. BVD virus can infect calves in utero leading to persistently infected (PI) animals that are difficult to detect but that shed massive amounts of virus, resulting in continuous contamination of the herd. The product will initially be launched in the EU and US, with other large beef-producing markets, such as Brazil, also considered. It will be administered to cattle upon arrival at the feedlot or auction house, which is a time of high susceptibility to infection. The drug will prevent exposed animals from developing clinical disease and will reduce viral shedding by PI animals until they are identified and separated from the herd. The drug will be added to standard processing procedures to minimize labour time and cost. The BVD project is in TRL-6 stage and is predicted to reach market in 6-8 years’ time with peak sales of €150 million in the EU and US alone. Key opinion leaders (KOLs) are supportive of the product and a number of investors have expressed their interest. In Phase I, ViroVet will conduct market research and consult with KOLs in Europe and in other major beef markets to ensure successful introduction of the product. A comparative analysis of regulatory requirements will assist in the refinement of the business plan that will minimize time to market and maximize rapid return on investment. Contracts with investors will be finalized and a term sheet will be signed.

Keywords: innovative disease control strategy,antiviral drug,pharmaceutical,small molecule,bvdv,pestivirus
Geochemical Controls on the Ice Nucleating Efficiency of Volcanic Ash (INoVA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-22
End date: 2020-01-21
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Ice formation in the atmosphere has a major impact on the properties and lifetime of clouds yet is one of the least well understood processes indirectly affecting the Earth’s climate. Heterogeneous ice nucleation by airborne solid particles (‘ice nuclei’) exerts a profound influence on clouds by raising the temperature at which ice can form relative to by homogeneous freezing of supercooled water droplets. Volcanic ash from explosive eruptions is increasingly recognised to be capable of acting as ice nuclei but factors determining the ash ice nucleating efficiency have yet to be elucidated. As for mineral dust from arid and semi-arid regions, physicochemical properties of the solid particles such as crystallinity, mineralogy and composition likely play a role in their ice nucleating efficiency, but this remains poorly understood and has not been systematically investigated for volcanic ash. In addition, the influence of thermochemical processes/conditions in the source magma, in the eruption plume and cloud, and in the ambient atmosphere on ash ice nucleating efficiency is not known. The proposed research will address this gap in knowledge through an experimental approach uniquely bridging volcanic geochemistry and atmospheric science, to establish the link between ash ice nucleating efficiency and its physicochemical properties and magmatic, eruptive and atmospheric history. A range of natural ash and synthetic ash, generated and treated under controlled laboratory conditions, will be studied. Experimental data will be parameterised for use in model simulations to predict regional ice nuclei concentrations based on an Icelandic eruption scenario. Collectively, the proposed research, training and knowledge transfer activities will enhance the future prospects of both the Fellow and host, while contributing to the greater benefit of society by improving understanding of the potential impacts of ash emissions from explosive eruptions on the atmosphere and on climate.

Keywords: heterogeneous ice nucleation,volcanic ash,physicochemical properties,clouds,atmosphere,eruption plume,climate