Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Determining optimal approach to deliver malaria vaccine in seasonal transmission areas through Phase 4 implementation research (SMV delivery)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Guinea,Spain,Netherlands,United Kingdom,Mali
Call: Improving modes of delivery, deployment, and uptake of vaccines through phase IV/implementation research (HORIZON-JU-GH-EDCTP3-2023-02-two-stage, 2023)
Start date: 2024-10-01
End date: 2028-03-31
Duration (months): 42.0
Total project cost (EUR): 4352355.0
EU funding (EUR): 4352355.0
Participants: 5
Project status: SIGNED

Seasonal malaria chemoprevention (SMC), the administration of sulphadoxine-pyrimethamine and amodiaquine (SP+AQ), during the peak period of malaria risk has proved to be a highly effective malaria control measure in areas where transmission of malaria is highly seasonal; SMC was administered to 45 million children in 2021. Still, malaria remains the main cause of hospital admissions among young children in many parts of the Sahel and sub-Sahel and additional control measures are needed to protect children. The malaria vaccines RTS,S/AS01E, and R21/Matrix, provide a high level of protection during the first few months after a primary series of vaccination, or after a booster dose, but efficacy wanes progressively during the following months and years. Thus, in areas with seasonal malaria transmission, one potential use for these vaccines, which provide a high but relatively short period of protection, is administration of an annual booster dose given prior to the malaria transmission season in children who have received three priming doses of the vaccine in the first year of life. However, there is a debate about the best approach to delivery of the booster doses and the main objectives of this study are to determine whether annual booster doses of RTSS,AS01E vaccine administered pre-transmission season through a mass campaign will achieve better coverage and higher impact on the incidence of malaria than pre-transmission booster doses delivered by an EPI programme at vaccination centres. This will be a pragmatic implementation study involving two cohorts of children. Two districts that have comparable malaria epidemiology, social structure, coverage of EPI vaccines, and access to treatment will be identified in both Mali and in Guinea from the list of districts that are selected for roll out of RTS,S/ASO1E vaccine by the Ministry of Health. This project will provide important information on the optimum delivery which could save many lives.

Keywords: seasonal malaria vaccination delivery,coverage,impact,acceptability,cost effectiveness
Asymmetric DNA-based OrganoCatalysis (DNAOrgCat)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Asymmetric catalysis is arguable the most appealing way to prepare complex chiral scaffolds. In this context, metal-catalyzed transformations have been more widely used in comparison to metal-free strategies. Nonetheless, the complexity involved with the transition metal catalysts, the toxicity often associated with the metals and the none-negligible amounts of waste produced during the reactions have caused significant drawbacks. The advent of green and sustainable chemistry brought organocatalysis into prominence (2021 Nobel Prize in Chemistry), allowing the field to emerge as an effective alternative to classical metal-based asymmetric catalysis. Small Molecule Organocatalysts (SMOs) have been used in a plethora of different synthetic transformations. Their stability to air excludes the need for inert conditions and ultra-dry solvents and thus minimizes overall research expenditure. Among all the SMOs reported throughout the years, N-heterocyclic carbenes (NHCs) have shown great promise, offering interesting prospects for both academic and industrial applications. In the last decade, bio-hybrid DNA-based asymmetric catalysis (DAC) has appeared as an attractive tool providing excellent enantioselectivities on a broad range of reactions. DNAOrgCat aims at combining, for the first time, asymmetric organocatalysis and bio-hybrid catalysis to develop new, highly enantioselective, scalable and sustainable organocatalytic processes. To reach this goal, we will design, synthesize and ultimately evaluate a series of NHC-modified oligonucleotides on a model Stetter reaction. We will also develop sustainable catalytic systems based on recyclable, solid-supported, modified oligonucleotides, which will ultimately be implemented to large-scale continuous flow processes. By doing so, not only do we intend to expand the current frontiers of DNA-based asymmetric catalysis, we also wish to set a mind change and unquestionably place DNA-based catalysts in the chemists’ toolbox.

Keywords: asymmetric catalysis,organocatalysis,biohybrid catalysis,n heterocyclic carbenes
A Primitive solar Atmosphere around The young Earth? (APATE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2784505.0
EU funding (EUR): 2784505.0
Participants: 1
Project status: SIGNED

The existence of an atmosphere enriched in H and He around the Earth as it formed has often been proposed. One hypothesis suggests that it could have been captured from the gas present in the proto-planetary disk, before its evaporation. Subsequently, a secondary atmosphere would have been degassed or brought in by a late veneer of chondritic/cometary material. Although this model is regularly evoked using giant planets for comparison, there is no geological proof for its existence, except possibly for the neon in the Earth's mantle. While the model has a flaw (mainly relating to chronology, as the gas from the disk is lost in <6 My while the Earth formed over a period of more than 30My), the solar-type neon in the Earth's mantle is an argument for the existence of such a captured atmosphere, which partially dissolved into a magma ocean. A second scenario for a primordial H2/He-rich atmosphere is the degassing of a mantle that contained implanted solar wind. The APATE project aims to study the isotopic composition of neon in the Earth's mantle in order to determine if this composition is the same as that of the nebula or the solar wind material. I will investigate the degassing processes of magmas experimentally and numerically in order to study the isotopic fractionation that occurs during bubble formation and to determine whether the measured neon isotopic composition can provide an accurate composition for the original mantle. The project aims to calculate the amount of neon that can be incorporated into a magma ocean by establishing the atmospheric pressure of the captured atmosphere and by studying the dynamics of the magma ocean. I will also explore the hypothesis involving solar wind irradiation. Using simulations of irradiation, I will identify those conditions under which this model is realistic and its implications for the Earth’s (isotopic/chemical) composition. The origin of light solar volatiles will then be explored by the APATE project.

Keywords: origin of volatiles on earth magma ocean solar wind irradiation
Development of a multifunctional biomaterial patch for buccal delivery of peptide-analogue treatments (BUCCAL-PEP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Ireland,Denmark,Germany,France,Netherlands,United Kingdom,Portugal
Call: Smart and multifunctional biomaterials for health innovations (RIA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 3986438.75
EU funding (EUR): 3971426.5
Participants: 8
Project status: SIGNED

Oral delivery of peptide-analogues (a macromolecule) is one of the great challenges in pharmaceutical research. Thus far, only five peptide-analogues have been converted to oral formulations such as tablets/capsules and all face distinct challenges including low bioavailability, dosage control, patient administration inconvenience and restrictions in use (e.g. undesirable food interactions). The BUCCAL-PEP consortium will join hands to develop a multifunctional biomaterial patch which allows, for the first time, buccal (in the cheek) delivery of peptide-analogue therapies, thereby overcoming these challenges through unique integration of a permeation enhancer (SDC) with biomaterials and a peptide-analogue. The novel formulation enables peptides to diffuse across the mucosal multilayer, thereby effectively achieving their intended pharmacological response. The novel approach will result in an improved quality of patient life and increased treatment compliance. Within this project, the consortium will design, select and manufacture a lead product (with Type 2 Diabetes as showcase indication) that will be validated for performance in in vivo large animal studies. Additionally, a Health Technology Assessment will be performed to support the development an evidence-based value proposition and aid in the development of a commercialisation strategy. The final deliverable of the project is a patch that is pre-clinically validated and ready for clinical trials in the desired showcase indication. Overall, the BUCCAL-PEP project will provide a platform technology for oromucosal delivery of peptide-analogues that will be suitable for a broad range of experimental- and approved peptides-analogues therapies across a multitude of disease indications. BUCCAL-PEP will enable novel peptide-based treatments to emerge, which otherwise might not have reached the market due to incompatibility with the currently available administration routes.

Keywords: buccal administration,peptide analogue delivery,oral patch,type 2 diabetes
Ionic Propulsion in Atmosphere (IPROP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Germany,Belgium,France
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-11-01
End date: 2027-10-31
Duration (months): 48.0
Total project cost (EUR): 2999994.0
EU funding (EUR): 2999993.75
Participants: 11
Project status: SIGNED

This project aims to bring ionic air-breathing propulsive systems beyond the pioneeristic phase, exploring their capabilities and improving their performance. Non-thermal plasma for atmospheric propulsion is a subject of recent investigations: model airplanes and vertical lifters have recently flown with this type of propulsion, but the potential of this technology is much higher. Many open aspects in this field deserve to be investigated, from fundamental research on ion production to geometric optimization of electrodes and integration of propulsion systems in existing aircraft. To this purpose, a complete research program is proposed, starting from breakthroughs in fundamental research to be achieved through theoretical, numerical and laboratory studies. The following steps will lead to develop improved and optimized propulsive units, with the objective of designing and building an airship model (technological demonstrator) with ionic propulsion. A further objective is the conceptual design of a full-scale stratospheric airship: for this aircraft the high risk approach of the project will give rise to different possible choices about propulsion, depending on the results achieved in the first steps. In particular, for this airship concept at least fully ionic propulsion and combined conventional/ionic propulsion will be considered. A major long-term impact is expected for ion-powered airships, which could act as stratospheric platforms replacing many satellite functions, such as telecommunications, remote sensing, disaster risk management in civil protection, offering these services at much lower costs, with the benefit of being recoverable systems. A fully successful program may lead to top-level, fully ion-powered airships: thanks to the propulsive units without moving mechanical parts, powered by solar energy, they would have extremely long operation times, low maintenance and very low pollution levels.

Keywords: electrohydrodynamics ehd,electroaerodynamics,ionized gas,ionic wind,corona discharge,ehd thruster,ionic propulsion,ionic air breathing propulsion,ion powered airship,stratospheric airship
Green tax reform for a just climate transition (GRETA) (GRETA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Finland
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499743.0
EU funding (EUR): 1499743.0
Participants: 1
Project status: SIGNED

The European Union’s ambitious climate policies will have wide-ranging distributional impacts in societies. Yet, it is poorly understood how to mitigate the adverse impacts and how compensation mechanisms can be designed to allocate funds to those most in need. GRETA introduces an integrated approach for climate policies and inequality, and will increase our understanding on how to reach climate targets equitably. In the theoretical part, we characterize a green tax reform that creates sufficient incentives to cut emissions, generates public revenue for the green transition, and ensures that costs are fairly distributed across the society. Individuals hold private information about their productivity and abatement costs. In this setting, income taxation and carbon pricing are not separable and, strikingly, effective carbon prices should vary by income-level. The theory shows that the optimal tax design depends on a limited set of sufficient statistics, including: (1) carbon price incidence per income group, (2) emission semi-elasticity per income group and (3) individuals’ perception of within- and across-income inequality. In the empirical part, we quantify these sufficient statistics (1)-(3) using price variation created by the Energy Crisis of 2022 and a rich administrative data covering all Finnish firms and individuals. First, we estimate the within- and across-income inequalities created by the sudden rise in electricity prices and, using plausibly exogenous ending dates of fixed-term contract, estimate the individual-level emission semi-elasticities. Second, we study how the energy price spikes contribute to inequality though their different impacts on firm owners and workers, where our identification is based on a shift-share instrument approach. Third, we study the fairness perception by a large-scale survey where responses are linked to the administrative data. These empirical findings allow us to quantify the optimal tax design numerically.

Keywords: green tax reform,climate change,optimal income taxation,carbon incidence,inequality
Center for Ethics in Public Affairs (ETICA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Panel: Social Sciences and Humanities
Countries involved: Armenia
Call: ERA Chairs (HORIZON-WIDERA-2023-TALENTS-01, 2023)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 2499453.81
EU funding (EUR): 2499453.81
Participants: 1
Project status: SIGNED

ETICA, Center for Ethics in Public Affairs at the American University of Armenia, under the direction of ERA Chair Professor Maria Baghramian, will become a national hub for analysing and researching key ethical issues in the public sphere. ETICA will carry out its activities under the four pillars of Research and Internationalisation, Training and Capacity Building, Outreach and Public Engagement, and Structural Reform, focusing on the following objectives: to internationalise research through a collaborative research project on Trust and Hope in a Time of Poly-crises; to create long-term research and training resources in ethics in public affairs; to offer training opportunities in professional, applied and research ethics; to engage the public in participatory deliberations on key ethical issues; to generate policy briefs informed by its theoretical, empirical and participatory findings; to encourage reform in research management at institutional and sectoral levels; and to assist in strengthening international research funding applications. ETICA will have a lasting impact on the development of research and training in public ethics in a small country with limited resources. By recruiting an excellent team of researchers, the Center will also contribute to revitalizing research and publication in the humanities. Through its training and capacity building activities, ETICA will promote the development of codes of professional conduct in research and governance. By engaging with the general public, in the course of town halls, youth juries and deliberative mini publics, ETICA will strengthen the practice of open and reasoned discourse on issues of public significance in a post-Soviet country steadily moving towards democratisation. ETICA will introduce changes in research management, research ethics and funding application governance that will hasten the integration of AUA, and ultimately the Republic of Armenia, in the EU and the global research community.

Keywords: ethics,trust,hope,democracy,youth,citizen outreach
Establishing Target Engagement and Selectivity for CTP Inhibitors in Cells: Synthesis and Application of CHOLesterol Probes for a Comprehensive MAPping of the Cholesterol Interactome (CholMap)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 247553.28
EU funding (EUR): 247553.28
Participants: 1
Project status: SIGNED

Cholesterol is a structural component of membranes and plays a key role in human health by regulating the fluidity of membranes and affecting signaling pathways. Intracellular cholesterol transport proteins (CTP) are responsible for maintaining cholesterol homeostasis by regulating local cholesterol concentrations, arising from de novo biosynthesis or dietary sources. Dysregulated cholesterol transport is associated with cardiovascular disease but also Alzheimer's and cancer. Despite the obvious importance of CTPs, a chemical probe to investigate binding, inhibition and selectivity profiling of CTP inhibitors does not exist. CTPs are all structurally related in their cholesterol binding site. Therefore, the development of a selective modulator to study their individual function and possible therapeutic relevance is challenging. Only a few CTP inhibitors have been reported so far and it has not been possible to conclusively evaluate their cellular selectivity. In CholMap, I aim to introduce a universal sterol-based affinity probe with the ability to bind all CTPs and evaluate the selectivity of CTP inhibitors in cells. This sterol-based probe would be bifunctional containing a diazirine, which is transformed into a carbene via UV irradiation for covalent binding to CTPs, and an alkyne for binding to a functional tag via click chemistry. I will synthesize differently constituted probes and test them in vitro for their efficiency. An optimized sterol-based affinity probe would be used in a chemoproteomic workflow to determine the target engagement and the selectivity of different CTP inhibitors. The introduction of a universal sterol-based affinity probe in combination with a chemoproteomic workflow would constitute the first example of CTP selectivity profiling in cells. The results will also enable me to uncover new sterol-binding proteins including new potential drug targets, as well as providing a large dataset accessible to the whole research field.

Keywords: proteomics,cholesterol transportation,chemoproteomic workflow,competitive pull down assay