Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Scintillator-He3 Array for Deep-underground Experiments on the S-process (SHADES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Italy,Italy
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2026-01-31
Duration (months): 72.0
Total project cost (EUR): 1346595.0
EU funding (EUR): 1206066.25
Participants: 2
Project status: SIGNED

A crucial source of neutrons in stars is the nuclear reaction Ne-22(alpha,n)Mg-25, of major importance for the synthesis of heavy elements. Currently there is an established picture of the astrophysical scenario but only limited availability of reliable experimental data, with several key ingredients under dispute. SHADES will perform a direct measurement of the reaction to resolve the main open questions. The goal is to decrease the uncertainty in the astrophysical reaction rate in the relevant temperature range by at least one order of magnitude, providing a significant leap ahead from the state of the art. SHADES will deliver an increase in sensitivity of more than two orders of magnitude over the state of the art. We will gather direct experimental data over the entire astrophysically relevant energy range. We will construct a neutron detector specifically designed for this measurement. Beam-induced background, a severe problem in the past, will be discriminated by measuring the neutron energy while still maintaining a very detection high efficiency. In recent years research on capture-gated techniques and combinations of different detector types to measure neutron energies has increased greatly. The novel detector array will perfectly fit this profile and find a large field of applications also outside of nuclear astrophysics. The main measurements will be done with the new accelerator LUNA MV, allowing long-term high-intensity, high-energy resolution alpha bombardments. An extended, recirculating gas target will guarantee target stability under intense ion beams. The location of the experiment deep underground will drastically reduce the external background, the main limiting factor so far for low-energy measurements. In my team there will be also leading experts in the field to update the current stellar models using the new dataset to provide a greatly improved and much more robust picture of this important branch of stellar nucleosynthesis.
Sustainable growing media for vegetable cultivation (MOSSWOOL)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Finland
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-09-01
End date: 2019-12-31
Duration (months): 28.0
Total project cost (EUR): 3488781.25
EU funding (EUR): 2442146.0
Participants: 2
Project status: CLOSED

A Finnish SME, Novarbo, has developed a sustainable and cost-effective way to manufacture hydroponics growth medium Mosswool® as a sustainable and compostable drop-in replacement for the non-biodegradable stonewool growth media (e.g. Rockwool insulation material), which has the majority market share for the hydroponic cultivation of vegetable crops. There is a strong desire for sustainable alternatives to stonewool and other mineral-based media. Some greenhouse growers have already switched to coconut coir-based materials, despite their harmful environmental impact during manufacture. The innovation is to utilize sphagnum moss, harvested in EU countries by using a new technique that skims only a top layer of moss. Ecological and hydrological balance of the bogs are preserved and they return to their former state within 3 years. Patented manufacturing techniques are used to fabricate Mosswool® slabs. A demonstration-scale manufacturing plant will be designed and the production process fully costed to allow for a robust investment case. The objectives are production scale-up from pilot to demonstration plant scale, cost and eco-optimization of Mosswool® slabs and performance testing at test institutes and commercial greenhouses. Life-cycle assessment of Mosswool slabs compared to competing products will be made. Benefits of Mosswool® will be communicated by augmented Novarbo’s sales network. Reliable production cost and capacity calculations will be developed to include in a robust business plan with reliable investment calculations for industrial scale production, and private or SME-instrument Phase 3 funding will be prepared. SME instrument funding of demonstration, testing and scaling-up would support company competitiveness and growth underpinned by a strategic business plan. Novarbo is the leading expert in professional horticulture and greenhouse technology with an established greenhouse cultivation business. Export operations cover more than 60 countries.

Keywords: mosswool,hydroponics growth media,sphagnum moss,sustainability,compostable,production demonstration line,waste heat utilisation,novarbo,biolan
Soraprazan - a new regenerative therapy for Stargardt's disease (Soraprazan)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Germany,Norway,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Clinical research on regenerative medicine (H2020-SC1-2017-Single-Stage-RTD, 2017)
Start date: 2017-12-01
End date: 2021-11-30
Duration (months): 48.0
Total project cost (EUR): 5792425.0
EU funding (EUR): 5792425.0
Participants: 12
Project status: CLOSED

Soraprazan – a new regenerative therapy for Stargardt’s disease Abnormal accumulation of lipofuscin in the RPE cells is a hallmark in Stargardt's disease. As lipofuscin cannot be removed from the RPE cells in the eyes neither spontaneously nor with existing therapies, the accumulation of lipofuscin in the RPE cells of the eyes results in the degradation of the RPE cells and consequently in worsening of visual acuity and could lead to blindness. Soraprazan was able to show removal of lipofuscin in RPE cells. Aim of the phase II trial in this project is to evaluate savety and efficacy or orally taken Soraprazan treatment compared to placebo.

Keywords: lipofuscin,vision loss,depigmentation,regenerative,rpe cells,stargardt s disease
Instrumented 3D-Printed Miniature Muscles for Cardiotoxicity Screens of Cancer Therapies (IN-3D-CAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Rationale: Cardiotoxicity side effects are a recurrent problem for cancer therapies, fatally illustrated by the death of numerous patients treated with anthracycline chemotherapeutics. More recently, cardiac complications have also been found for antibody-based and immunotherapy treatments. Microphysiological systems and organs-on-chips may provide part of the long-term solution to these issues, by introducing improved means for studying human tissue in vitro. Main objective: The overarching objective of IN-3D-CAN is to establish instrumented in vitro 3D models of human cardiac muscle for high-throughput cardiotoxicity screening of cancer drugs and therapies. Methodology: In a recent first-author paper in Nature Materials, we reported the first entirely 3D-printed organ-on-chip with integrated sensors: A heart-on-a-chip with strain sensors for tracking engineered 2D cardiac thin films. In this proposal, I significantly expand on this 3D printing methodology, focusing on thicker 3D tissue models that better recapitulate native cardiac muscle. I will leverage the insights of the supervisor to perform toxicity screening of a range of cancer therapies. Outcomes: The proposal will establish unique tools for long-term and high-throughput studies of drug toxicity on human cardiac muscle in vitro. It will further provide unique insights into the cardiotoxicity of several cancer therapies on human cardiac muscle. Finally, the techniques for 3D printing will be widely applicable for biomedical micro-devices. Career: I am applying for an MSCA-IF-EF-RI, to reintegrate to DTU(DK), after more than 4 years abroad as Postdoc at Harvard Uni. (US) The fellowship will serve as year 1 and 2 of a 4-year assistant professorship. The host DTU Nanotech has committed to provide funding for year 3 and 4. The key career development objective is therefore to train me to become an independent group leader. Thus, In-3D-CAN will serve as immediate and long-term platform for my research.

Keywords: microphysiological systems,organs on chips,3d printing
University students' negotiation of physics identity in informal physics programs (iPER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-11
End date: 2020-06-10
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

University students continue to develop their physics identity by engaging in practices that are central to the physics community. However, many students also participate in other relevant practices, such as teaching and outreach. For some, teaching and outreach may be integral to their experience doing physics and building identity, although that may be counter to messaging from advisors or academia about their value. In this work, we investigate university students negotiation of physics identity after they have volunteered in informal physics programs for primary school children. We hypothesize that university students’ physics identity is foster or reshaped by the interactions and experiences they have in the program. We analyze university students interviews and responses to pre and post surveys using a blended framework of Self-Determination Theory and Community of Practice frameworks. From this analysis, we extract the experiences that affect their physics identity as they negotiate their memberships in the informal and formal physics communities of practice.

Keywords: physics,identity,informal learning,stem,steam
Description of information transfer across macromolecules by concerted conformational changes (CONCERT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2021-06-30
Duration (months): 72.0
Total project cost (EUR): 1950000.0
EU funding (EUR): 1950000.0
Participants: 1
Project status: CLOSED

Signal transduction in biology relies on the transfer of information across biomolecules by concerted conformational changes that cannot currently be characterized experimentally at high resolution. In CONCERT we will develop a method based on the use of nuclear magnetic resonance spectroscopy in solution that will provide very detailed descriptions of such changes by using the information about structural heterogeneity contained in a parameter that is exquisitely sensitive to molecular shape called residual dipolar coupling measured in steric alignment. To show how this new method will allow the study of information transfer we will determine conformational ensembles that will report on the intra and inter-domain concerted conformational changes that activate the androgen receptor, a large allosteric multi-domain protein that regulates the male phenotype and is a therapeutic target for castration resistant prostate cancer, the condition suffered by prostate cancer patients that have become refractory to hormone therapy, the first line of treatment for this disease. To complement the structural information obtained by nuclear magnetic resonance and, especially, measure the rate of information transfer across the androgen receptor we will carry out in a collaborative fashion high precision single molecule Förster resonance energy transfer and fluorescence correlation spectroscopy experiments on AR constructs labelled with fluorescent dyes. In summary we will develop a method that will make it possible to describe some of the most fascinating biological phenomena, such as allostery and signal transduction, and will, in the long term, be an instrument for the discovery of drugs to treat castration resistant prostate cancer, a late stage of prostate cancer that is incurable and kills ca. 70.000 European men every year.

Keywords: androgen receptor,intrinsically disordered proteins,allostery,single molecule fret
An Integrated Platform for Incresed FLEXIbility in smart TRANSmission grids with STORage Entities and large penetration of Renewable Energy Sources (FLEXITRANSTORE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Spain,Albania,Germany,Spain,Spain,Ireland,Cyprus,Bulgaria,Hungary,Sweden,Bulgaria,Greece,Croatia,Slovenia,Belgium,Greece,Romania,Belgium,France,France,Portugal,Luxembourg
Call: Demonstration of system integration with smart transmission grid and storage technologies with increasing share of renewables (H2020-LCE-2017-SGS, 2017)
Start date: 2017-11-01
End date: 2022-04-30
Duration (months): 54.0
Total project cost (EUR): 21399588.39
EU funding (EUR): 17008101.88
Participants: 34
Project status: SIGNED

FLEXITRANSTORE project shall develop a next generation of Flexible Energy Grid (FEG), which provides the technical basis to support the valorisation of flexibility services, enhancing the existing European Internal Energy Market (IEM). This FEG addresses the capability of a power system to maintain continuous service in the face of rapid and large swings in supply or demand, whatever the cause. Thus, a wholesale market infrastructure and new business models within this integrated FEG should be upgraded to network players, incentivize new ones to join, while demonstrating new business perspectives for cross border resources management and energy trading. The strategic objectives of FLEXITRANSTORE are: to enhance and accelerate the integration of renewables into European energy systems and to increase cross border electricity flows across Europe. Flexibility is one of the keys to meeting these strategic objectives. A range of state-of-the-art ICT technologies / control improvements will be exploited to enhance the flexibility of this novel energy grid while increasing the utility of the existing infrastructure by integrating storage and demand response management. From a market perspective, state-of-the-art ICT technologies / control improvements will be applied to develop an enhanced market model on an integrated platform, for flexibility services and to support cross border auctioning and trading of energy. The FEG components and the digital market infrastructure will be deployed in 8 Demonstrations which will take place in 6 countries (Greece, Bulgaria, Cyprus, Slovenia, Belgium, Spain), focusing on illustrating specific functions and serving real needs and existing challenges.

Keywords: de icing,market coupling
Multi-Payload satellite as an innovative service for technology experimentation in space (MPSAT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Spain
Call: SME Instrument (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The project objective is to provide a low-cost and fast service for test and evaluation of technology devices in outer space. The most outstanding added value of this proposal is to bring the space sector closer to technology developers through the standardization of the payload integration. The rate of production of new components and technologies in the European space industry is currently not accomplished to the availability of opportunities for in-orbit testing. European space industry needs to increase rapidly the maturity level of these components, in order not to lose the leading position in terms of technological competitiveness and innovation. This situation brings the commercial opportunity for a low cost and time effective service to evaluate new technologies in space environment, providing a multiple payload integration service to gain heritage as fast as the industry is demanding at present. This innovative business opportunity, called Multi-Payload Satellite (MPSAT), is focused on achieving a new concept of space mission based on small satellites for in-orbit demonstration. The proposed project will develop a feasible and flexible service, drastically increasing the availability of opportunities for in-orbit testing for the whole technology developers’ community. The proposal concept mimics a previous successful initiative known as Multi-project Chip Wafer (MPW). MPW is a foundry service in microelectronics, where the share of the non-recurrent costs involved in the manufacturing of several integrated circuits on a single run drastically reduces its price. In this way, MPSAT service offers flight opportunities to the technology developers without resources for managing their own mission, offering dedicated payload slots and including all the mission steps as a unique kit: Mission management, platform assembly, payloads integration, operational and environmental tests, launch, and in-orbit experiment evaluation services.

Keywords: in orbit evaluation,payload integration,standardization,fast access to space,flight opportunities,space heritage,cubesat
Low dose Molecular Breast Imaging for improved cancer detection in dense breast tissue. (LDMBI)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: United Kingdom
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The 50% of women with dense breast tissue who are currently screened for breast cancer by mammography have large numbers of cancers missed, and non-cancerous features erroneously diagnosed, due to the difficulty of a mammogram distinguishing tumours from dense breast tissue. In dense breasts, around 1 in 2 cancers is missed by mammography. Molecular Breast Imaging has much higher sensitivity (a better cancer detection rate) and specificity (fewer false alarms) than mammography, particularly for dense breasts. Its use as a screening technology is currently restricted due to its high radiation dose and inability to guide a biopsy. This feasibility study will investigate the technical, economic and regulatory viability of Kromek’s technology to being adopted in optimised diagnosis pathways. Kromek currently supplies detectors into the MBI market, and have a number of innovative platform technologies to add to the current offering to create a system to address these barriers to adoption. Work in this Phase 1 study will identify the dose vs cancer detection balance, to guide the application of the technologies to the market needs. We predict sales in the EU and USA of 147 million Euros in the first five years after commercialisation, which will help address the approximately 110 thousand women in Europe whose cancers in dense breasts are currently missed by mammography.

Keywords: breast cancer screening,molecular imaging
Lightweight Active Orthosis for kids who are unable to walk due to brain damage (WalkableFUTURE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Hungary
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-10-01
End date: 2015-12-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

One in a thousand newborns has a severe condition of cerebral palsy (CP) so that he or she will not be able to walk at all, ever in life. This affects 5000 babies born each year in the EU, and cumulatively ~63,000 children. There is no known cure for the disease. Some active walking aids (e.g. exoskeletons) may help the child to walk, but they cannot be adapted for children, nor to the special lower limb deformities prevalent in this disease. We will disrupt the walking aid market with a new concept: robotized orthoses. We will build on professional walking aids and motorise them. Ours will be the only active orthosis for children with CP aimed for overground walking, and physiotherapy, as well. Our system does not take into consideration the “faulty” signals from the body, instead it is built on the ideal walking patterns pre-programmed, while a range of sensors anticipate the will of the user. The extensive survey through our distribution partners and potential clients revealed the need for our device that changes the quality of life in such a remarkable way. We will capitalise on the rapid growth enabled by the ease of market entry and fast distribution opportunity, to help hundreds of children every year.

Keywords: ict of walking,motorised orthoses,cerebral palsy