Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Antecedents and Consequences of Biculturalism (BICULTURALISM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-10-01
End date: 2014-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

One of the major challenges confronting new entrants to a country is how to manage their cultural identity as they are exposed to the competing values, norms, and behavioral expectations that exist between their culture of origin and the new local culture. Whether they arrive as sojourners or long-term immigrants, entrants are faced with a fundamental dilemma of whether and to what degree they should maintain their original cultural identity and in what part they should adopt the new host culture. Although many have touted the benefits of second-culture exposure, researchers have failed to consider how the differential patterns of cultural identification that individuals adopt may provide important traction in predicting performance advantages. Moreover, the process by which individuals absorb a cultural identity, the role played by second-culture exposure in shaping socio-cognitive skills, and the resulting implications for performance have also received little theoretical and empirical attention. By drawing on a diverse set of research methodologies and by working at multiple levels of analyses, the comprehensive research agenda outlined in this proposal is aimed at addressing these knowledge gaps in 3 ways. First, I will investigate the potential benefits of biculturalism, relative to other acculturation strategies, for social tolerance, creativity, decision-making, and negotiation outcomes. Second, I will explore the role of integrative complexity as the underlying mediating mechanism linking biculturalism and performance-related success. Finally, I will examine the antecedents of biculturalism and test the boundary conditions of biculturals’ advantage. The proposed research will afford psychologists with a greater understanding of the bicultural experience, its antecedents, and its consequences as well as present organizational scholars, practitioners, and policy makers with a comprehensive framework for how to successfully manage cultural diversity.

Keywords: acculturation,biculturalism,multicultural experience,integrative complexity,cognitive style,priming,frame-switching,living and performing abroad
The non-coprime k(GV) problem and generation of finite groups (GROUPS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Hungary
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-05-01
End date: 2013-04-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Group theory is one of the oldest branches of modern mathematics. It has truly fascinating connections with combinatorics, representation theory, coding theory, algebraic geometry, physics, and chemistry. The Classification (Theorem) of Finite Simple Groups is one of the greatest intellectual achievements of the human mind. It describes the basic building blocks of finite groups. Its proof is over 10 000 journal pages long and it incorporates 100 years of mathematics. One of the motivations of this proposal is to find applications in pure mathematics of this remarkable theorem (CFSG). Attila Maróti, the researcher of the present proposal, is an active participant in this area of research. After three and four years of successful work in the United Kingdom and the United States respectively he intends to return to Hungary and pursue his research program in the stimulating and supportive environment of the Rényi Institute. His efforts would be enforced by the complementary skills of the experts at the host in the theory of universal algebra, and in profinite group theory. In addition, the researcher would receive advanced training in extremal graph theory, and in combinatorics which are important for his future career. The ultimate goal of the researcher is to integrate his research at the host and start new or revive past scientific collaboration with members of the host. The project would strengthen and diversify the mathematical profile of Hungary, one of the twelve new Member States of the European Union, by introducing an important new line of mainstream research and by providing new links to colleagues worldwide. The project would also contribute towards reversing brain drain. In short, the proposed project would enhance the potential and the attractiveness of the European Research Area.

Keywords: finite group,representation,conjugacy class,maximal subgroups,generation,graph
Dissent and Urban Spaces (DUS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-10-01
End date: 2014-04-02
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

What makes citizens choose a particular form of protest and how does space function as mediator between these citizens and their political acts? These questions address the international social contentions of this century. This research offers an interdisciplinary analysis of urban spaces and protests, with a focus on the late 20th and early 21st centuries. The research’s goal is to enrich the discourse about the relationships between dissent and public space. Addressing these relationships, this research offers a window into how people use, manipulate, claim, and appropriate urban space while advocating for their own values. Thus far, we have no coherent theory explaining the relationship between space and contentious politics. We do have significant empirical and theoretical accounts of how prevailing forms of popular struggle vary and change from one political regime to another, but there is little written about the spatial physicality of these struggles. This research seeks to further understand the phenomena of dissent. It contributes to this goal by setting the rather abstract notions of citizenship and democracy into a concrete framework of time, place and meaning. The research aims are: 1.Building an analytical, interdisciplinary framework for the spatial physicality of dissent. 2.Advancing a comparative display of forms of citizenship and cultural identities. 3.Offering significant new perspectives on how different and changing notions and practices of citizenship relate to issues in our multicultural society. The project is based on empirical analysis in 10 cities, with the aide of translators and research assistances.

Keywords: political history,social geography,urban sociology,planning and architecture
Identifying the Heat Shock Factor -1 Longevity Assurance and Proteostasis Co-regulators and Target genes (HSF-1 LONGEVITY/PROT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-08-01
End date: 2013-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The Heat shock Factor 1 (HSF-1) is a transcription factor that upon activation enters the nucleus and regulates the transcription of its target gene networks. In the nematode C. elegans, HSF-1 is critical for the regulation of a variety of fundamental biological functions including development and stress resistance. In addition, it mediates protection from toxic protein aggregation and longevity facilitated by reduction of the Insulin/IGF signaling pathway, functions that point to HSF-1 as a promising target for the development of neurodegeneration therapies. Despite its key regulatory importance and therapeutic potential, little is known about the gene netwroks regulated by HSF-1 and its co-factors. Here I propose a systematic study designed to explore the different aspects of HSF-1 roles in regulating longevity and countering toxic protein aggregation. First the timing in which HSF-1 regulates longevity and counter toxicity associated with the aggregation of the Alzheimer’s disease linked peptide, Aβ. Next, the relations with components of the Insulin/IGF signaling pathway and its target genes networks will be studied at the correct temporal pattern, followed by exploration of the molecular co-factors that interact with HSF-1 at the longevity assurance time window. The proposed study will shed light on the molecular mechanisms that prevent late onset neurodegenerative disorders to emerge early in life and will point to new avenues towards the development of novel neurodegeneration therapies.

Keywords: aging,longevity,neurodegeneration,neurosciences,insulin/igf signaling,heat shoch factor,gene network,co-factors
Gamma-ray bursts - Current and Future (GRB-SMB-2008)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-04-01
End date: 2012-03-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Gamma-ray bursts (GRB) are one of the most energetic phenomena in Astrophysics, producing large energy releases at cosmological distances on very short time scales. Multiwavelength observations of these sources have the potential to tell us about the source, but the prompt and afterglow of GRBs fades very quickly and telescopes must be on target within seconds. Much has been learned and continues to be learned from the afterglows of GRBs, but we have now entered a new era with the successful launch of Fermi (formerly GLAST). Now it will be possible to measure the high energy emission of these sources. This is a ground-breaking project in the study of GRBs with complementary aims in the short, medium and long term. All aspects of the project will run simultaneously with the emphasis shifting as time goes on. The three strands are necessary to ensure no gap in activity and a sucessful transition. (1) In the short to mid-term the applicant will continue her research into the multi-wavelength aspects of GRBs and their prompt emission with Fermi, Swift, INTEGRAL and collaborations in the follow-up community. (2) In the mid term, the applicant with involve herself more with the focusing experiments in the host institute. (3) In the long term, the applicant will get involved in the one of the proposed generation gamma-ray mission - GRIPS, with a few to developing the mission concept and keeping scientific output at the same time. Please note that my EIF Marie Curie Fellowship ran from the 01/04/2006 until 31/03/2008 and this proposal was submitted on the 30/09/2008 - within the 6 month post MC Fellowship deadline.

Keywords: physical sciences,astronomy,astrophysics
Delivery of siRNAs to hematopoietic stem cells using nanoparticles (RNAI IN HSC VIA NP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2010-01-01
End date: 2013-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

RNA interference (RNAi) is a ubiquitous and highly specific, endogenous, evolutionarily conserved mechanism of gene silencing. Since the discovery that RNAi occurs in mammalian cells, RNAi has emerged as a powerful tool for elucidating gene function and identifying potential drug targets. Harnessing RNAi holds enormous promise for therapeutic use for diseases that have proven difficult to treat with conventional drugs. RNAi can also be exogenously activated either by transducing cells with vectors to express small hairpin RNAs (shRNA) or by introducing already processed short double-stranded RNAs (siRNAs) into the cytoplasm of cells. To realize the potential of siRNAs for in vivo drug discovery and therapy there is a need to overcome the considerable hurdle of intracellular delivery across the plasma membrane. siRNAs are not taken up into most cells in vitro in the absence of a transfection reagent. For many cells, mixing siRNAs at nanomolar concentrations with a lipid transfection can efficiently induce gene silencing. However, some important cells, including primary lymphocytes and hematopoietic stem cells, remain highly resistant to lipid transfection schemes. We have recently developed nanoparticles that target integrin b7 that is expressed on leukocytes involved in gut inflammation. Using this approach, we revealed cyclin D1 to be a potential anti-inflammatory target in inflammatory bowel diseases. The goal of this proposal is to explore the hypothesis that targeted nanoparticles entrapping siRNAs can be developed to induce in vivo gene silencing in hematopoietic stem cells. Using this strategy, we plan to identify key genes responsible for pluripotent hematopoietic stem cells (pHSC) self-renewal properties. This will provide a powerful technique to investigate the contribution of individual genes in maintaining the phenotypic and functional properties of pHSC, and ultimately may provide a way to improve engraftment during bone marrow transplantation.

Keywords: rna interference (rnai,sirnas),hematopoietic stem cells,drug delivery and targeting,nanomedicine,transplantation immunology
Small Wind Turbine Composite Blade PRoperties ON Demand by Means of Functionally Graded Materials (PROND)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-04-02
End date: 2012-04-01
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The use of renewable energy sources in Europe will increase, leading to more sustainable energy mix and reduced greenhouse gas emissions. Wind has been the world's fastest growing renewable energy source for the last seven years, and this trend is expected to continue with falling costs of wind energy. Small wind systems can produce electricity cheaper than the grid and payback their embedded carbon within months. Today Europe has literally millions of homes and businesses waiting to benefit from the effective deployment of this technology. The main goal of this project is to investigate coupled mechanical and aero-dynamic properties the self-adaptive blade of small wind turbine made of functionally graded composite materials.A combination of non-destructive experimental and numerical simulation methods will be employed. Both structural and wind tunnel test results will be used in two ways: to derive knowledge of a structural and aerodynamic properties of a structure and to update the Finite Element and Computational Fluid Dynamic coupled in Fluid-Structure Interaction approach according to values obtained from tests. This information will be used to introduce the blade self adapting concept into the internal architecture design by means of functionally graded materials. An optimization techniques for numerical models parts will be applied in the pursuit of maximum structural efficiency, maximum performance of the turbine and a low cost of the unit. Such a combination demands to take advantage of knowledge from several fields: structural identification, fluid mechanics, composite materials, measurement methods, signal processing, numerical modeling, model updating, optimization, statistics. As a result of this project the optimized design and prototype of the self adaptive blade of small wind turbine will be delivered. Also a set of updated numerical models will be developed.

Keywords: wind energy technology,mechanical engineering
Peptide-Toxins as probes for the Structure –Activity Relationship (SAR) investigation against the nicotinic acetylcholine receptors (nAChRs) subtypes (PETOXSAR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-05-01
End date: 2012-04-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

This reintegration project will give to the applicant the opportunity to use the additional insights and expertise that he has gained during his previous MC-IEF to build on his experience for an independent academic career. The aim of this project is to investigate the structure - activity relationship (SAR) of synthesized peptides that selectively blocks the nicotinic acetylcholine receptors and the innovation of potential pharmaceutical important agents. Nicotinic Acetylcholine receptors (nAChRs) are included into one of the most important therapeutic targets for various diseases, including myasthenia gravis, Alzheimer’s and Parkinson’s diseases, schizophrenia, as well as for the cessation of smoking. Thus, the PeToxSAR group will use synthetic peptide-toxins as probes in order to investigate the structure-activity relationships of peptides against nAChRs aiming to address important questions in the field of neurobiology. The focus of this project will be on achieving the following ambitious scientific objectives: Design, synthesis development and biological investigation of several series of rich disulfide bond peptide-toxins analogues that present high selectivity against nAChRs. Application of computational methods for the synthesized peptide-toxins against produced models of nAChRs subtypes. Biological studies of the synthesized peptides against several nAChRs subtypes. NMR conformational analysis of the most important synthesized peptide. The approach that will be used in this ERG project will further advance the researcher scientific capabilities and enable him to acquire new broader knowledge in the peptide science field. The partners of the PeToxSAR believes that the above experiments and the obtained data will provide details in atomic level for the structure activity relationships of these biological systems and these data will comprise the stage in order to design and synthesize potential pharmaceutical important peptides against nAChRs.

Keywords: pharmaceutical chemistry,computational chemistry,neurobiology,peptide chemisty,peptide - toxins,structural chemistry
Mechanisms of innate immune activation of the intracellular bacterial pathogen L. monocytogenes. (IMMUNITY TO LISTERIA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-12-01
End date: 2013-11-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

A central problem in microbial pathogenesis is how cells of the immune system recognize and respond to pathogens, and conversely, how pathogens avoid and/or manipulate the host response. In order to approach this problem, we have chosen to focus on the interaction between the intracellular bacterial pathogen, Listeria monocytogenes and the immune cells, macrophages. Macrophages, express surface and cytosolic innate immune receptors that recognize conserved molecules of microbial origin, leading to induction of host inflammatory responses. Ironically, while macrophages are important effector cells of the immune system, they are permissive hosts for intracellular pathogens, and it is still not clear how they sense and respond to live intracellular pathogens. This research proposal aims to directly identify mechanisms by which intracellular pathogens activate the innate immune system. We recently performed a forward genetic screen for L. monocytogenes mutants that induce an enhanced or diminished host innate immune response. Using this unbiased approach we identified L. monocytogenes multi-drug resistance (MDR) transporters that controlled the magnitude of a host cytosolic surveillance pathway, leading to the production of Type I interferon response. In this research program we wish to continue with this approach and (I). Identify additional L. monocytogenes molecular determinants that involved in activation of host innate immune pathways. (II). Using genetic and biochemical approaches we will study the regulation and function of the newly identified L. monocytogenes MDRs in vivo and their role in activation of the Type I interferon response. (III). Identify bacterial ligands that activate the Type I interferon response. We hypothesize that bacterial ligands are transported by the MDRs to the host cytosol where they are recognized. We will use bacterial mutants over-expressing MDRs to identify the MDR-specific substrate(s).

Keywords: intracellular bacterial pathogene,innate immune response,l. monocytogenes