Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ER Stress and Photoreceptor Degeneration in Drosophila (DROSOERSTRESS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2008-12-01
End date: 2012-11-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The endoplasmic reticulum (ER) is the cell organelle where secretory and membrane proteins are synthesized and folded. The presence of unfolded/misfolded proteins in the ER causes stress to the cell (“ER stress”) and activates the Unfolded Protein Response (UPR), a cellular response to restore homeostasis in the ER. The presence of misfolded proteins and activation of the UPR have been connected with many diseases and pathological conditions. My goal is to elucidate the molecular mechanisms that regulate neuronal degeneration and cell death induced by ER strees, using Drosophila melanogaster as a model system. To achieve this goal, I propose the following specific aims: 1. Analysis of the molecular mechanisms required for induction of cell death in the context of ER stress. 2. The mechanism of induction of cell death by Xbp1spliced 3. Developmental role of the UPR during photoreceptor differentiation.

Keywords: health sciences,drosophila,er stress,photoreceptor,eye,unfolded protein response,neural degeneration
Biologically Active Organic Compounds Interacting with Adenine-binding Proteins (BIOACTIVECPDS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Czechia
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2010-01-01
End date: 2015-05-01
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Proposed are rational design and synthesis of novel patentable organic compounds that are envisioned to be active against various adenine-binding proteins, e.g. kinases. The structures contain heterocyclic cores relatively unknown in the literature and will mimic interations of purine-containing biological substrates (especially ATP) with proteins that are relevant in oncology. The compounds will be synthesized by modern methods of organic synthesis, namely by ring-closing olefin metathesis and will be profiled in biological assays that include diverse biological targets, especially those that are related to the treatment of cancer.

Keywords: natural sciences,health sciences,biologically active compounds,kinases,adenine-binding proteins,organic compounds
Development of Culturally Appropriate Neuropsychological Tests for the Greek Population (DECANT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-01-01
End date: 2011-12-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

We aim to explore and demonstrate the flaws inherent in the current practice of transferring neuropsychological tests from American or other Anglo-Saxon societies to other countries and cultures and to develop an empirically-based and scientifically sound conceptual framework within which potential pitfalls in culturally sensitive neuropsychological assessment and test development can be avoided. This will lead to the development of a method for creating or adapting a culturally appropriate neuropsychological measure to any culture. We expect our findings to be of interest not only to scientists and clinicians from any European country that is currently developing the field of neuropsychology, but even those in non-European developing countries, as well as those working with ethnic and racial minorities in Western countries. While this project is relevant to all cultures, we will use the Greek case both as an example and a springboard to creating and norming neuropsychological measures that are appropriate for a given culture. The aims of the proposed investigation are in accordance with international trends in cross-cultural neuropsychology. On an applied level, we will provide a guide for the development of culturally appropriate tests for the Greek population and similar cultures, and yield a series of neuropsychological tests for use in clinical evaluations and research protocols. More importantly, perhaps, on a theoretical/scientific level, we will challenge some of the underlying assumptions in the field of ability measurement and offer new insights regarding the universality of the constructs typically measured in a neuropsychological assessment. Therefore, this work will enhance European competitiveness by challenging the current worldwide dominance of North American test publishing companies.

Keywords: cross-cultural psychology,clinical neuropsychology,cognitive assessment,norms
Control of photo-induced energy transfer in functionalized carbon nanostructures towards design of nanoscale applications (COPET)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2008-10-01
End date: 2012-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The proposed research project aims at advancing a combined approach of quantum dynamics methodology and quantum control techniques applicable on photo-induced energy transfer processes on nanostructures consisting of carbon nanohorns, or CNHs, and molecular compounds with several stable equilibrium configurations, or MCCs. The ultimate objective of such studies is the design and development of nanoscale devices, such as plastic electronics, solar energy conversion cells, and artificial photosynthetic molecular complexes. For this purpose, we propose to combine the time dependent density functional theory with the Natural Transition Orbitals representation in order to study the electronic transition density which governs the photo-induced energy transfer process between electronic excited states in functionalized carbon nanostructures. The excitonic dynamics will be further investigated with quantum dynamical methods which take into account the coherent excitonic time evolution in interaction with the vibrational degrees of freedom in such systems. The manipulation of the photo-induced transfer process will be achieved by switching on demand between the different equilibrium configurations of the molecular compounds, which often have different physical properties, used for functionalization of the carbon nanohorns, by taylored laser pulses. Alternatively, the control of the photo-induced transfer process will be achieved by the introduction of metallic nanoparticles in the proximity of the functionalized carbon nanostructures and the resulting near-field effects on the electromagnetic density of states due to the scattered light. The scientific innovation expected, following the successful implementation of the present project, may reveal future technologies based on advanced functional nanoarchitectrures consisting of CNHs and MCCs in the areas of opto-electronics, solar energy conversion cells, and artificial photosynthetic systems.

Keywords: photochemistry,energy transfer,functionalized carbon nanohorns,several equilibrium configurations,quantum dynamics and control,density functional theory,plastic electronics,organic solar cells
Reactive transport in subsurface flows. Imaging the flow organization and predicting solute motion, mixing and reactivity (REACTIVEFLOWS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France,France
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-03-01
End date: 2012-02-29
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 2
Project status: CLOSED

The scientific goal of the project is to develop methods for characterizing and predicting contaminant transport in aquifers. The sustainable management of groundwater has been a topic of greatest interest within the European strategy for improving the environment due to the growing risk of contamination of groundwater resources from a wide variety of stresses including point and diffuse sources of contamination, over-abstraction and saline intrusion. The fate of contaminants in the subsurface is controlled by the complex organization of groundwater flows, due to the existence of heterogeneous geological structures at different scales. It is also determined by (bio) chemical reactions that take place as contaminants travel in the subsurface. However, the effect of the flow heterogeneity is not currently taken into consideration in most existing models and theories, which represent a severe limitation of our predictive capabilities. However, recent theoretical, numerical and experimental developments suggest that significant progresses can be made to image the flow heterogeneity and integrate it into reactive transport models. Thus we propose an original methodology based on :(i) the development of inverse methods for imaging the flow organization in natural media from geophysical, flow and tracer measurements; (ii) the definition of reactive transport models that integrate this flow organization; (iii) the confrontation of models to relevant experimental data and field cases. Since the project results are expected to provide a long missing link between the flow organization and effective reactive transport, it will lead to more realistic, physically based models of transport in aquifers. The project will combine physical, geophysical and (bio) chemical methods. It will form the basis of a long term collaboration between the host group (Géosciences Rennes) and the previous IEF group (UPC Barcelona), that have developed different, yet highly complementary, approaches.

Keywords: natural sciences,physical sciences
Functional connectivity between the primate amygdala and the medial prefrontal cortex: role in extinction of emotional memories. (AMY-MPFC-EXTINCTION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-10-01
End date: 2013-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The purpose of this study is to bridge over an important gap between rodent and human studies. Studies in rodents have shown the importance of the reciprocal connections between the medial-prefrontal cortex (mPFC) and the amygdala, and described their contribution to the acquisition and extinction of fear-associations. In parallel, imaging studies in humans have observed activation in the mPFC-amygdala pathway during regulation of emotion, and behavioral studies in patients have revealed that dysfunction of the network underlies different psychiatric disorders. Indeed, relevant disorders are different forms of failures to regulate emotion, mainly different forms of anxiety disorders, such as PTSD. The amygdala-mPFC network is much more complex in primates than in rodents and expanded during evolution. Moreover, elaborate paradigms that mimic real-world scenarios can not be tested with rodents. Similarly, imaging studies in humans have several limitations. For example, differentiating sub-nuclei within the amygdala (and mPFC) is limited by the spatial resolution; observing complex interactions between areas during the task is limited by the low temporal resolution; and many physiological manipulations are impossible in humans. We will first record simultaneously from the amygdala and mPFC of awake- behaving monkeys during rest, electrical stimulation, and temporary inactivation of one of the structures; then, we will record during acquisition and recall of extinction of fear-associations. Our main goal is to characterize interactions between the mPFC and the amygdala, different sub-nuclei within the amygdala, and different sub-areas of the mPFC. This project will help bring the research in primates to a baseline closer to that in rodents, and will therefore validate (or not), and expand on established findings with relevance to clinical applications. Importantly, the next step of this project will study more complex forms of extinction.

Keywords: learning,memory,extinction,consolidation,computational neuroscience,amygdala,prefrontal cortex,electrophysiology
Development and Evaluation of a Cognitive Rehabilitation Program for Persons with Multiple Sclerosis (MS COGNITIVE REHAB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-01-01
End date: 2012-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Multiple sclerosis (MS) is a common, progressive neurological condition. Up to 65% of people with MS (PwMS) will experience cognitive impairments as a result of the disease. Cognitive impairments in MS are persistent and have a significant negative impact on the ability to work, perform daily activities, and independently participate in society. Therefore, successful management of cognitive impairments through rehabilitation is critical for this population. Current knowledge about the effects of cognitive rehabilitation in MS is based largely on studies that tested interventions focused on remediating impairments. Comparatively, less is known about the effectiveness of compensatory-based cognitive rehabilitation for this population. My past research has involved developing and testing a self-management, compensatory cognitive rehabilitation program for PwMS. This research showed initial positive results and indicated that participants increased their knowledge and self-efficacy regarding cognitive symptoms, and reported using cognitive strategies in daily activities. However, in order to determine the programs clinical impact and continue to examine it as an evidence-based intervention, more research is needed to modify the program and evaluate it under a more rigorous methodological design. In addition, the program needs to fit the MS rehabilitation structure in Israel and be culturally appropriate for Israeli PwMS. Therefore, this study will include four steps: (1) Learning about MS cognitive research and practice in Israel, (2) Modifying the cognitive program with the aid of a multi-disciplinary work group of MS researchers, professionals, PwMS and caregivers, (3) Selecting screening and outcome measures that fit the revised program, and (4) Testing the revised cognitive program using a mixed methods design that includes a randomized controlled trial and process evaluation. This project will be documented for future replication in other European counties.

Keywords: multiple sclerosis,cognitive rehabilitation,symptom management,complex health intervention,program development,process evaluation
Food shortages, hunger and death in 11th to 13th century Catalonia: an alternative model of analysis for short-term crises (CRISES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2008-10-01
End date: 2012-12-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The research project that we are proposing aims to study the food crises (bad years, food shortages, dearths and famines) and the mortality crises which periodically afflicted Catalan medieval society between the early XIth century and the late XIIIth century. We will attempt to confirm, refute, redefine and perfect the historiographic models which have been constructed to explain their causes, mechanisms and interrelations. Using Catalonia as a laboratory of analysis and interpretation of the short term crises, in the words of E. Labrousse, and starting with a large variety of approaches , we propose: 1) to construct a chronology of the crises on a regional scale, determining as precisely as possible their geographic reach, periodicity, duration and relative severity also paying attention to the interrelations between food shortages and mortality crises and the relationship between regional crises and famines and epidemics which concomitantly effected the rest of Europe; 2) to consider the importance of distinct factors associated with food shortage (climatology, regional and international commerce in cereals, interconnection of urban markets, feudal wars and large international conflicts, accumulation of reserves or storage, speculation, etc.) in the unleashing, development and outcome of crises; 3) to gauge the consequences of famines and deaths on the economy, society and demography, both urban and rural; 4) to analyze the role of different social actors involved in the crises as well as the anticyclical policies implemented by the different spheres of power in order to insure the food supply of the kingdom and the cities; 5) to analyze the role played during the crises by charitable institutions, both ecclesiastic and private.

Keywords: humanities,history,medieval history,economic history,famine,shortage,dearth,subsistence crisis,food crisis,bad year,epidemics,mortality crisis,catalonia
Managing Global Human Resources in UK Multi National Corporations (GLOBHRM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-01-01
End date: 2011-12-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Internationalisation of firms has been a key issue in international business research for several decades. Much attention has been given to the process; market entry modes; organisational structures in the multinational firm; and the impact of culture on firms’ internationalisation. The process is often placed within the broader context of globalisation in general. Whether it is internationalisation or globalisation being examined, these two processes have fundamentally affected the study of disciplines, notably economics and management. Partly due to the relatively closed political and economic systems that existed until the late 1980s in Central Europe (CE) and Russia, these regions have been under-researched in the areas of internationalisation, globalisation, and HRM. Three CE countries have received the most significant foreign direct investment: Czech Republic, Hungary and Poland. The proposed study draws upon the disciplines of economics and management theory to examine how UK-owned companies have made the decision to invest in these three countries. The study will examine the enabling factors that help contribute to successful subsidiary investments, with a particular focus on the management of HR between the subsidiary and UK Head-Quarters. The study will focus solely on UK-owned firms with brown and greenfield subsidiaries. It will examine the importance and constantly evolving role of global HR managers/directors. It will explore the well researched link between business strategy, the use of HRM practices and performance in the subsidiary. The research will identify characteristics of successful FDI in the region and policy recommendations will be made based on these findings.

Keywords: economics,applied economics,management of enterprises,international economics,industrial economics
Territorial dynamics of the world maritime system (MARITIME SYSTEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2009-01-01
End date: 2011-12-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

This research project aims at analysing the relationships between maritime transport and regional development. It proposes an innovative approach based on the graph analysis of the world maritime system based on two types of data. First, a global database on vessel movements (Lloyd's 1996 and 2006) is analyzed with TULIP software in order to better understand how ports are situated and performing relatively in the network. Second, classic socio-economical indicators on ports' urban and regional environments are collected from existing databases and integrated with the new maritime indicators. In the end, we can expect two types of results. First, to learn more about the interdependence of port performance and regional performance, and to see how this relation varies over time and accross regions of the world. Second, to provide interested parties with new indicators of port performance (e.g. for port authorities) and regional port dynamics (e.g. in Europe, in relation with regional integration policies and shortsea shipping, motorways of the sea). In terms of academic outcomes, this would be the first attempt to elucidate the multi-level organization of maritime transport in relation to regional development on a world scale, and to contribute to the current wave of research on multi-level networks in geography where air transport analysis remains dominant as opposed to the lack of studies on ports and maritime transport.

Keywords: regional geography,economic geography,human geography,transport economics