Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Enabling digital technologies for Holistic Health-lifestyle motivational and assisTed supeRvision supported by Artificial Intelligence Networks (H2TRAIN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: Spain,Austria,Germany,Italy,France,Finland,Poland
Call: General according to ECS-SRIA 2022 (IA) (HORIZON-KDT-JU-2023-1-IA, 2023)
Start date: 2024-05-01
End date: 2027-04-30
Duration (months): 36.0
Total project cost (EUR): 24050477.23
EU funding (EUR): 7276633.5
Participants: 35
Project status: SIGNED

H2TRAIN proposal is funded on the sixth edition of the Electronic Components and Systems (ECS) Strategic Research and Innovation Agenda (ECS-SRIA) topics and major challenges for enabling digital technologies in holistic health-lifestyle supported by artificial intelligence (AI) networks. Biosensors for e-health and smart tracking of sport and fitness are a class of devices that is dominating the consumer and professional market with an unprecedented growth. Despite the impressive capabilities of recent approaches, several prospective revolutionary improvements are still open points, mainly in relationship with four factors: sensing new biosignals and tracking new activity patterns; improving battery lifetime and energy management for continuous use; and secure, reliable and efficient data analysis with AI algorithms and connectivity with the IoT. H2TRAIN aims at advancing the state of the art in this respect, taking profit from the remarkable properties and synergistic potential of one-dimensional (1D) and two-dimensional (2D) materials (1DM and 2DM), enabling more sensitive, efficient, and miniaturized biosensing capabilities within the established CMOS technology framework. This will contribute to the growth of e-health services assisted by AI and will fortify the development of Internet of Things (IoT) applications in health & wellbeing and digital society. H2TRAIN not only facilitates digital technology but also involves the development of new 1DM and 2DM-based devices for sensing, energy harvesting and supercapacitor storage. These innovations serve to integrate sport and health activities into IoT applications, making them accessible as wearable technology. H2TRAIN combines mature CMOS technology products for health and sport sensing with embedded intelligence as a cross-sectional technology. This combination offers a broad spectrum of technology demonstrators (TD) based on advanced sensors, such as tattoo sweat, C-reactive protein, cortisol and lactate.

Keywords: internet of things iot,artificial intelligence ai,edge computing,embedded intelligence,more than moore devices,heterogeneous integration,biosensing devices,energy harvesting
Aerosols, Convection, Clouds, and Climate Sensitivity: understanding the processes and climate impacts of the interactions between aerosol pollution and tropical convective clouds (AC3S)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1830134.0
EU funding (EUR): 1830134.0
Participants: 1
Project status: SIGNED

Interactions between anthropogenic aerosol particles and clouds are the largest source of uncertainty in the historical radiative forcing of climate. Aerosol effects on tropical deep convective clouds could constitute a major component of this forcing, but the underlying physical mechanisms are poorly understood, and the associated global climate forcing has not been rigorously quantified before. These knowledge gaps have been highlighted as an urgent research challenge in recent assessment reports by the Intergovernmental Panel on Climate Change (IPCC) and the World Climate Research Programme. AC3S seeks to address this challenge by applying state-of-the-art observational and modeling techniques that span the disciplines of aerosol-cloud interactions and climate science. First, I will perform regional analysis of satellite observations, in-situ aircraft measurements, and high-resolution numerical simulations to investigate hypotheses about the physical mechanisms that govern the interactions between aerosols and tropical deep convective clouds. Second, I will analyze global satellite observations to attain the first rigorous assessment of global climate forcing from these aerosol-cloud interactions. Finally, I will synthesize the evidence and quantify the implications of the results for Earth’s climate sensitivity to carbon-dioxide forcing and 21st century global warming. This integrated approach will advance the field of aerosol-cloud-climate interactions and ensure that the results are immediately accessible to a broad audience, including policymakers and future IPCC assessment reports.

Keywords: aerosol cloud interactions,atmospheric convection,aerosol radiative forcing of climate change,climate sensitivity
Development and clinical validation of an innovative biomaterial combined with stem cells to advance spinal cord regeneration and transforming the landscape of injury treatment. (SpinoSave)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Austria
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 36.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Spinal cord injury (SCI) leaves patients with devastating disabilities-paralysed muscles and loss of feeling. No efficient therapies exist, making damaged neural tissue repair an urgent unmet clinical need. Regenera SA proposes a new neuro-regenerative strategy: the use of a smart biomaterial that captures and retains stem cells for delivery of regenerative factors to the damaged spinal cord. Our research focuses on chemical hydrogels, three-dimensional polymeric networks that can absorb large amounts of fluid and capture stem cells. We propose an innovative combined biomaterial and stem cell paradigm to counteract the cascade of events in the subacute phase following the initial cord lesion: the resorbable hydrogel will be loaded with the patient’s own stem cells and implanted in close contact with the injured portion of the spinal cord. The captured stem cells will provide a stream of factors that will facilitate regenerative repair of the injured cord.

Keywords: spinal cord injury,neurosurgery,biomaterial,stem cell therapy
Relationships of receptive grammar acquisition with musical rhythm processing and executive functions (REGRAMM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

Language is one of the hallmarks of what it means to be human and grammar is a core linguistic ability that makes us able to understand (receptive grammar) and express (expressive grammar) the relationships between words in sentences. This ability is fundamental for participating in the educational, economic, social and cultural life of society, while impairments of grammar can lead to life-long difficulties in these areas. The acquisition of grammar is, thus, one of the most important developmental steps in young humans. Recent theories emphasize the complex interplay between linguistic and non-linguistic processes in grammar acquisition. Two non-linguistic processes that have been proposed to be tightly linked with grammar, primarily with receptive grammar, are executive functions (EFs) and rhythm processing. The interplay of these abilities with receptive grammar, however, have never been systematically tested. The proposed project aims to fill this gap by investigating the relationships of receptive grammar with EFs and rhythm processing in an individual differences behavioral study in a large group of children. The project will also develop and validate a gamified battery that will facilitate conducting large-scale in-person or web-based studies with children in the future. The results of the proposed project will help to determine if an exhaustive model of grammar acquisition needs to incorporate EFs and rhythm processing. Disentangling factors affecting grammar acquisition will help to improve the health and well-being of children by optimizing their learning environment and developing effective treatment programs for children with language disorders. The gamified battery I will implement will facilitate large-scale data collection with children in developmental cognitive sciences and lay groundwork for developing research-based apps to facilitate cognitive development of children with typical and atypical language development.

Keywords: grammar,executive functions,musical rhythm,school aged children,individual differences,gamification
Revolutionizing Male Reproductive Health with Probiotics against Endocrine Disruptors (REPROBATIO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 209483.28
EU funding (EUR): 209483.28
Participants: 2
Project status: SIGNED

Environmental pollution has emerged as a key contributor to the decline in male fertility, a significant health issue in Western countries. This decline is driven by contaminants of emerging concern that disrupt steroidogenesis and gut microbiota, leading to altered sex hormone levels and nutrient availability. Additionally, these pollutants act as epigenotoxic agents, impacting male germline epigenetics and posing risks to embryo development when such epimutations are inherited by the zygote. In this context, there is an urgent need not only to reduce pollutant emissions but also to develop innovative strategies to mitigate their health impacts, particularly on reproductive disorders and their transgenerational effects. The REPROBATIO project addresses this challenge by focusing on probiotics and postbiotics as a potential solution, leveraging their ability to restore gut microbiota diversity and enhance reproductive health, respectively, thus counteracting the effects of endocrine-disrupting chemicals (EDCs). The project pursues three main objectives: (O1) Conducting high-throughput screening to evaluate EDCs' impact on gut microbiota biodiversity and host-microbe interactions; (O2) Assessing probiotics' efficacy in mitigating EDC-induced gut dysbiosis; and (O3) Investigating probiotics and postbiotics as tools to alleviate EDC-induced reproductive disruptions in steroidogenesis and gametogenesis. Using advanced multi-omics approaches, alongside in vitro 3D (gut and testicular) and in vivo models, the project aims to provide a comprehensive map of how EDCs influence gut microbial biodiversity and hormonal regulation in the host. The outcomes of this research could revolutionize reproductive toxicology by offering novel microbiota-based strategies to combat EDC toxicity, improving overall health and reducing healthcare costs associated with exposome-derived male subfertility.

Keywords: endocrine disruptors,male fertility,gut microbiota,probiotics,postbiotics,reproductive toxicology,testicular organoids
The Geopolitics of Cloud Computing: How State-Firm Interactions Shape the Geography of Computation to Produce Digital Sovereignty and Dependence (GEOCLOUD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Finland
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2499458.0
EU funding (EUR): 2499458.0
Participants: 1
Project status: SIGNED

Today’s digital superpowers, the United States and China, exploit other countries’ reliance on their digital infrastructures for foreign policy and national security advantage. Governments in Europe, Asia, and elsewhere try to navigate this great power competition to retain “digital sovereignty”. A pivotal moment in these technology geopolitics is the ongoing “shift to cloud”. Instead of data being stored and processed on users’ own devices and on servers situated at organizations’ own premises, storage and processing are increasingly moving into “hyperscale” cloud data centres dotted around the world. This concentration generates significant economies of scale, decreases capital costs for firms and public sector organizations, and improves energy efficiency. However, it also creates new systemic risks, and since most of these data centres belong to U.S. and Chinese technology giants, will dramatically deepen other states’ technological dependence on them—unless smaller states succeed in shaping the shift to their advantage. In the GEOCLOUD project we will for the first time map this changing geography of computation and examine how different states are attempting to shape it with policies. Focusing on the digital superpowers’ key battlegrounds of Northern Europe and East/Southeast Asia, we will develop ways of measuring on a country level how exposed public sector and financial sector digital services are to cloud providers and how this exposure is evolving over time. We will use statistical analyses and interviews with policy makers and cloud executives to assess how effective government policies have been at shaping this exposure and at influencing the ownership and locations of hyperscale data centres. We will moreover theorize how government policies are interacting with large technology firms’ business strategies to generate new geopolitical dynamics that shape this geography of computation—and with it our prospects of digital sovereignty and dependence.

Keywords: technological dependence,innovation policy,distributed computing
Mechanised Reverse Mathematics in the Calculus of Inductive Constructions (MeReMath)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

“Foundations of mathematics” labels the centuries-old interdisciplinary vision to secure the logical basis for mathematics and its applications. Gödel's celebrated completeness theorem for first-order logic, identifying semantic truth with syntactic deduction, is a key result heralding the formal phase of that vision. Yet, this and other foundational results have not been fully characterised regarding their logical strength and computational content, limiting their understanding and applicability. The MeReMath project aims at closing this gap by systematically employing computer mechanisation to the programme of reverse mathematics, the ongoing effort to identify the exact logical principles underlying completeness and other results. For this analysis, the project will use the calculus of inductive constructions (CIC) as a logical base system, embodying an agnostic intuitionistic base system unveiling fine logical structure, and the Coq proof assistant, an interactive software tool for modelling logical reasoning and its computational content. Specifically, continuing previous research of the experienced researcher (ER) and the supervisor, the MeReMath project will contribute the first comprehensive constructive and computational analysis of the completeness theorem, taking into account all dimensions relevant to its logical strength and implementing modularly mechanised proofs as executable Coq code. By further accommodating a similar analysis of the related Löwenheim-Skolem theorems and other results in the canon, the main outcome of the MeReMath project will be a well-designed, collaboratively developed Coq library for (constructive) reverse mathematics, with novel logical observations and mechanisation techniques developed on the way. Hosted at the IRIF lab in Paris, the project will be developed in the centre of the original creation of CIC and Coq, providing a world-class environment for the project’s aims and the ER’s academic career prospects.

Keywords: mechanised mathematics,constructive logic,reverse mathematics,intuitionistic type theory,coq,completeness theorem
Mitochondrial Strategies in Ferroptotic Cell Death (Mito-FerroQuest)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Mitochondria serve as the epicenter of cellular metabolism. Their dynamic communication with other compartments within the cell ensures proper cellular function. My recent work reveals how mitochondria communicate with the plasma membrane (PM) to transport a redox-active lipid Coenzyme Q (Ubiquinone or CoQ). This communication is crucial for inhibiting a form of iron-mediated cell death called ferroptosis. Notably, CoQ is exclusively synthesized within the mitochondria and plays a pivotal role in maintaining the mitochondrial respiratory chain, as well as other metabolic pathways, such as pyrimidine synthesis, fatty acid oxidation and proline metabolism. My work highlights that cellular defense is primarily orchestrated from the mitochondria and surprisingly dependent on a molecule—CoQ—that is indispensable for mitochondrial function. This work shows that mitochondria—known as cell death inducers—protect cells from ferroptosis and opens several key questions that I will address in Mito-FerroQuest, including: i) Which proteins and metabolic pathways within the mitochondria dictate whether CoQ should be exported or retained within the mitochondria? ii) Do mitochondria have other ways to defend against ferroptosis, or is CoQ export their only defense? iii) Does mitochondrial communication extend beyond the PM and involve interactions with other organelles, such as the endoplasmic reticulum (ER), in protecting cells against ferroptosis? Answers to these questions will enhance our understanding of mitochondrial strategies in ferroptosis, potentially paving the way for new therapies in conditions where ferroptosis is implicated, like neurodegenerative disorders. Mito-FerroQuest sets the stage for my overarching goal of exploring ferroptosis in diseases with compromised mitochondrial function, such as Leigh syndrome, with the aim to assess its potential as a therapeutic target.

Keywords: mitochondria,ferroptosis,coenzyme q,metabolism
Lunar Impact’s Seismic and Telescopes European Network for Flash (LISTEN FLASH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 3499959.0
EU funding (EUR): 3499959.0
Participants: 4
Project status: SIGNED

Terrestrial Planetary Seismology aims to revolutionize our understanding of planetary interiors and seismic activity. After the Mars interior exploration by InSight seismometer, the next steps will be on the Moon, with three seismometer deployments planned for 2026/2027 : NASA's Far Side Seismic Suite (FSS) with a French spare InSight sensor, NASA's Artemis-3 Lunar Environment Monitoring Station, and the Chinese Chang'E-7 Lunar Seismometer. This ERC project hinges on detecting and locating lunar impacts, essential for constraining interior models, akin to seismic studies on Mars. It does this by deploying a network of three Earth-based telescopes to monitor Lunar Impact Flashes, complementing data from FSS and other lunar seismometers. This synergy enables precise impact location and timing, crucial for mapping lunar crustal and mantle structures of the lunar south hemisphere, including Schrödinger impact basin and South Pole shallow layers. Moreover, the project pioneers a multi-messenger approach in planetary science by combining seismic waveforms from impacts, high-resolution imaging of impact craters and impact digital twins to understand impact dynamics, lunar scattering and attenuation and lunar subsurface properties comprehensively. It aims to establish empirical relations between impact characteristics, seismic source parameters and seismic signals, enhancing our understanding of impact processes and enabling “natural” controlled seismology using impacts for future planetary exploration. With a robust implementation plan aligned with lunar mission timelines, this ERC project is based on partnership between IPGP and CNRS and promises to deliver groundbreaking insights into planetary seismology. It leverages expertise from planetary seismology, impact observations, and instrumentation, supported by international collaborations, to address fundamental questions about planetary interiors and enhance our understanding of planetary formation and impacts processes.

Keywords: planetary seismology moon mars lunar impact flash