Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High-throughput ultrasound-based volumetric 3D printing for tissue engineering (SONOCRAFT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain,Sweden,Germany,Portugal,Greece,Switzerland
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-04-01
End date: 2029-03-31
Duration (months): 48.0
Total project cost (EUR): 2999625.0
EU funding (EUR): 2999625.0
Participants: 9
Project status: SIGNED

Cardiovascular diseases are the leading cause of death globally. Efficient drug testing and disease models are needed to reduce their death toll. Myocardial cell constructs, e.g. spheroids, organoids, or organs on a chip, hold promise as disease models and can reduce animal testing. Unfortunately, cell constructs often lack the natural spatial complexity of their in-vivo counterparts, and consequently the cells remain immature and non-differentiated. Although, 3D printing offers great flexibility regarding the printed structure some limitations apply: the printing process is either slow, or not suited for printing the small-scale nested structures needed to create viable and functional myocardial cell constructs. To 3D bio print viable myocardial cell constructs, we must therefore break through several roadblocks limiting the potential of bioprinting. Our solution, coined SONOCRAFT, combines rapid volumetric 3D printing technology with ultrasonic particle manipulation to create centimetre-long aligned cardiac constructs within hydrogels. An artificial vasculature, incorporated within the hydrogel matrix, assures perfusion with oxygen and nutrients. Acoustic particle manipulation our tool of choice for cell manipulation as it is cheap, biocompatible, label-free and achieves the required resolution. To reach the objectives SonoPrint is equipped with a range of advanced features: (i) an acoustophoresis chamber for precise cell patterning in 3D; (ii) microfluidic nozzles for injecting multiple cell types; (iii) moveable printheads for flexible cell deposition; (iv) a temperature-controlled cell culture incubator; and (v) full automation for user-friendly operation. The visionary SONOCRAFT holds potential to transform tissue engineering, regenerative medicine, drug screening, and disease modelling with its technological breakthroughs overcoming current limitations in the field.

Keywords: vascularisation,cardiac constructs,cardiac toxicity,3d printing,ultrasound
Modularity and Reciprocity: a Robust Approach (MARARA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1473013.0
EU funding (EUR): 1473013.0
Participants: 1
Project status: SIGNED

Many of the most important questions in number theory and arithmetic geometry can be approached through the theory of Galois representations. A powerful tool to understand such representations is the Langlands programme, which describes the conjectural relations between Galois representations and automorphic forms. Landmark results in this direction include the proof of the modularity conjecture for (the Galois representations associated to) elliptic curves over the field of rational numbers and the proof of Serre's conjecture. Dramatic advances in our understanding of the structures of the Langlands programme in the last 20 years have made it possible to extend the scope of these theorems, both to more general classes of Galois representations and to more general base number fields. However, the most general and conclusive statements remain out of reach, in large part due to our poor understanding of Galois deformation theory in the most degenerate situations. The goal of this proposal will be to address central questions in the arithmetic of the Langlands programme by introducing new techniques into the study of Galois representations that are robust, powerful, and flexible. We will take a multi-faceted and cohesive approach that will lead to a greater understanding of fundamental open questions, and the proofs of new cases of important conjectures, in arithmetic geometry and the theory of automorphic forms, including the Fontaine--Mazur conjecture, the general form of Serre's conjecture, and the Langlands functoriality conjectures.

Keywords: galois representations,langlands programme
Advanced lightweight materials FOR Energy-efficient STructures (FOREST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Spain,France,Germany,Italy,Poland,Czechia,United Kingdom,Türkiye
Call: Advanced lightweight materials for energy efficient structures (RIA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2022-12-01
End date: 2026-05-31
Duration (months): 42.0
Total project cost (EUR): 4380720.0
EU funding (EUR): 4380720.0
Participants: 15
Project status: SIGNED

The transport sector has always been the focus of decarbonization in Europe. FOREST project proposes to combine the Reduce, Recovery and Reshape” drivers to face the decarbonization issues in the transport sector. Reduce: On the one hand, the greenhouse gas emissions of fuel vehicles and the energy consumption of electric vehicles reduction is one of the major dares of the global mobility sector. FOREST will reduce the structural weight of the vehicles by providing light components made of carbon fibre reinforced plastic. In this way, less fuel and energy consumption will be necessary to cover the same distance. On the other hand, fossil sources are being run out more and more. Besides, their use at the End-of-Life (EoL) has a negative impact on the carbon footprint. FOREST will develop new chemistries based on high-biobased content for polymers (bioacrylic, biobenxozaxine, biopolyamide) and additives (bio fire-retardant). In this regard, the fossil sources' dependency will be reduced. Recovery: The CFRP market is expected to increase more and more in the transport sector (aerospace, automotive, and heavy-duty). However, an important issue which has not totally overcome is the recovery of the large volume the carbon fibre waste to provide added value materials. FOREST will implement efficient methods to recover 100% of CF waste to develop high-quality semi-finished materials (non-woven, organosheet/SMC, LFT) for valuable transport applications. Reshape: The use of biobased and recycled materials is a real opportunity for mobility decarbonization but a detriment on the stability and safety properties of the performance could occur. FOREST will research the influence of the multifunctional properties on the biocomposite (mechanical, fire-retardant, and EMI-shielding). Therefore, FOREST will combine the biobased, recycled, and multifunctionality material nature to obtain sustainable solutions for the bus, aeronautic, and automotive sectors.

Keywords: biocomposite,biobased,recycling,multifunctional,carbon fibre,decarbonisation,mobility,transport
a Quasi Coherent Receiver Optical Sub-Assembly technology for improved access networks (qc-rosa)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Denmark
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-08-01
End date: 2025-07-31
Duration (months): 24.0
Total project cost (EUR): 3568952.5
EU funding (EUR): 2498266.7
Participants: 1
Project status: SIGNED

The Internet industry is growing enormously, and it already accounts for more than 2% of global emissions. Current infrastructures and technologies for access networks cannot answer the growing demand without high energy and environmental costs. With this project, Bifrost aims to deliver a fully developed, tested, and qualified breakthrough Receiver Optical Sub Assembly (ROSA) based on proprietary and patented Quasi Coherent technology, which increases signal detection by more than 10 times. Our technology can be seamlessly integrated into any existing transceiver on the market. Applied to the 5G fronthaul and ring architectures, it will significantly increase the infrastructure's reach from a max. of 10 km up to 20 Km. In fixed networks, it will enable meeting all classes of the new NG-PON2 standard, increasing reach, bandwidth, and number of users. This will have a major impact on Internet networks, reducing the need for costly and high energy-consuming central offices by up to 90%.

Keywords: network infrastructures,electronics,photonics,telecommunications,coherent detection,optical fiber networks,transceivers
FEDErated -system of systems- approach for flexible and interoperable energy COMmunities (FEDECOM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Spain,Belgium,France,Switzerland,United Kingdom,Germany,Serbia
Call: Energy Sector Integration: Integrating and combining energy systems to a cost-optimised and flexible energy system of systems (HORIZON-CL5-2021-D3-02, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 9474375.0
EU funding (EUR): 7635000.0
Participants: 21
Project status: SIGNED

Building on results of recently (or soon to be) concluded EU projects, FEDECOM aims to enable integrated local energy systems through sector coupling and cross-energy vector integration, increasing RES penetration via optimal utilisation of energy dispatch, storage and conversion assets. FEDECOM pursues the idea of electricity becoming the leading energy carrier, with power grids as the backbone for the decarbonisation of all energy sectors and aggregators as the cornerstone enabler of the potential exploitation. FEDECOM adopts and maximizes the potential synergies of two complementary deployment strategies: (i) direct electrification (e.g. via demand electrification), and (ii) indirect electrification (with power-to-X technology). FEDECOM will deliver a scalable and adaptable cloud-based platform composed of analytical, modelling and optimization services for planning, supervision and control of integrated local energy systems (power, gas, heating and cooling, industry, electric and hydrogen mobility). Optimized operations of the integrated systems will be demonstrated as part of hybrid RES/storage infrastructures, while enabling a holistic cooperative demand response (DR) strategy across federation of energy communities. With a concept of federated energy communities, FEDECOM unlocks the flexibility potential, enable energy exchange, and provide coordinated actions across near and remote sites, while maximizing the positive impact on grid transmission level. FEDECOM’s integrated package will be verified on three real large-scale pilots, each composed of multiple (federated) demo sites (communities): Spanish Virtual Green H2 Federation, Swiss Residential Hydropower Federation and BENElux cross-country e-Mobility Federation. After FEDECOM, local energy communities and service providers will be fully trained and upskilled via dissemination and engagement activities to take full ownership of FEDECOM solution and its business ecosystem.

Keywords: local energy communities cooperative dr strategy smart grid cross vector integration life cycle assessment advanced grid analytics system planning local marketplace
Understanding respiratory tract infections through minimally-invasive, daily nasal sampling in children (DailySAM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 1677858.75
EU funding (EUR): 1677858.0
Participants: 2
Project status: SIGNED

Pneumonia is the number one infectious cause of death in children worldwide. Many of the viruses and bacteria that cause pneumonia regularly infect, or colonize, the upper respiratory tract (URT) without causing disease. This drives community transmission but is also an important source of immunity. The processes and key host immune and microbiota factors that determine the infection kinetics, transmission and development of immunity during such infections need elucidation. I have recently optimized minimally-invasive nasal sampling analysis methods using Synthetic Absorptive Matrix (SAM) strips that now allow me to address these knowledge gaps. Through the daily collection of such well-tolerated nasal samples in children, I will study non-pathological, naturally-acquired URT infections, but also controlled infections in an ethical and safe manner using the live attenuated influenza vaccine. In addition, I will perform high frequency nasal sampling in groups of schoolchildren to precisely measure transmission events over time and even infer exposure. Incoming bacteria, viruses and the resident URT microbiome as well as mucosal host innate and adaptive immune responses will be quantified in parallel throughout infections using existing and new high-throughput assays, including an antigen array and microfluidic qPCR for 32 pathogens. Multi-omics integrative time-series analyses and mathematical modelling will be used to identify parameters that are central and predictive for pathogen acquisition, replication and clearance; as well as for transmission and immune boosting. Key novel markers and concepts will be validated using state-of-the-art in vitro mucosal models. The comprehensive and detailed understanding of URT infections obtained in this project can lead to better diagnostics, mucosal targeted therapies and vaccines, and provide a basis for the improved predictions of pathogen spread and public health effects of interventions at the population level.

Keywords: upper respiratory tract infection minimally invasive nasal sampling multi omics integration paediatrics mucosal immune responses individual infection kinetics host pathogen interaction live attenuated influenza vaccine
Birmingham and the West Midlands Metropole: Making Innovation Work in the Most Human of Places (HUMANiCITY)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EU prize
Destination: European Capital of Innovation Awards
Action type: Recognition Prize
Countries involved: United Kingdom
Call: The European Capital of Innovation Awards (iCapital) (HORIZON-EIC-2024-ICAPITAL-PRIZE-02, 2024)
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 1
Project status: CLOSED

Birmingham and the West Midlands is a metropole in England with a population of 2.9M people. In the past, engineering innovation propelled us to become the industrial powerhouse with a strong cultural identify. Now people-centered innovation is driving a transformation of our economy by combining our creative and engineering heritage through key clusters. This is what we mean by saying we are making innovation work in the most human of places. We are home to one of the youngest and most diverse populations in Europe. People are at the centre of our vision and strategy for innovation that aligns with plans for growth, digital, net zero and international engagement. Our submission describes how we coordinate our vibrant ecosystem based on deep partnerships between stakeholders through planned activity, while encouraging grass roots development and inclusive innovation to flourish. We illustrate some of the 100+ incubators and support programmes available to help anyone launch and scale a business and our ambitious plans to develop new innovation districts to transform some our most deprived communities through colocation and engagement. We highlight how we proactively collaborate with other cities & regions across Europe. Finally, we explain how we are innovating local government, creating forums for citizens to participate and investing in skills to ensure people are not excluded from the emerging jobs and the wider digital world we live in. If we were to be successful, this would provide a new injection of momentum to build on the wave of civic confidence created through the Commonwealth Games in 2022. We would invest the prize and proactively collaborate with the excellent iCapital community to further improve citizen engagement, the scaling up of businesses with underrepresented founders, stimulate our base of small businesses to innovate and develop more innovate approaches to tackling deprivation.

Keywords: people centered vision and strategy,inclusive innovation,collaboration,local decision making,inclusive growth
The role of plant microbiota in the evolution of fungal pathogens and their repertoires of secreted proteins (FungalSecrets)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

FungalFungal plant pathogens have a devastating impact on crop production. Decades of research have addressed the molecular interaction of pathogens with plant immune responses and have established effector proteins as key molecules secreted by pathogens to interact with plant receptors. Studies of fungal pathogens have revealed a large diversity of predicted effector proteins expressed during plant colonization, yet the functional relevance of most remains unknown. I hypothesize that fungal pathogens secrete a diverse repertoire of effectors to manipulate host-associated microbiota and facilitate host invasion. As distinct plant species assemble distinct microbial communities, I hypothesize that effector evolution and host specialization of pathogens, in part, is driven by the host-associated microbiota. FungalSecrets, will combine bioinformatics, evolutionary analyses, molecular microbiology approaches and plant infection assays. Our research will focus on 2000 effectors and effector-like proteins produced by four pathogens infecting wild relatives of crop plants. We will predict the protein structures of effectors to identify new homology relationships and to make inference of protein interactions and co-evolution. Next, we will identify antimicrobial properties and determine the effect of each effector protein on the growth of 400 bacteria isolated from the host plants of the pathogens. To overcome challenges of heterologous protein expression we will use different expression systems. To obtain mechanistic insights into microbial interactions, we will conduct detailed analyses of a selected set of candidate effectors with pleiotropic functions in virulence and microbiota manipulation. FungalSecrets is based on innovative hypotheses and will cover a fundamental knowledge gap related to the ecology of fungal pathogens. The research will have implications for applied crop research and will stimulate new research of fungi associated with human and animal microbiota.

Keywords: fungi,plant pathogens,plant microbiota,effectors
Speckle Technology and Digital Biomarkers of Microvascular Function for Monitoring Cardiovascular Diseases (STIMULUS) – Hop On (STIMULUS - Hop On)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Finland,Greece
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 28.0
Total project cost (EUR): 599875.0
EU funding (EUR): 599875.0
Participants: 2
Project status: CLOSED

The STIMULUS Hop-On project aims to enhance the original goals of the STIMULUS project, enabling early detection of cardiovascular and kidney diseases through the innovative use of miniature laser sources combined with the principle of Self-Mixing Interferometry (SMI). This high-sensitivity measurement technique allows for the extraction of richer datasets related to blood flow dynamics within the microvasculature, reaching depths of approximately 1 mm, thus offering valuable insights into vascular health. The project will develop a compact, low-power monolithic sensor based on Vertical Cavity Surface Emitting Laser (VCSEL) technology, facilitating integration into consumer and wearable electronics. This integration is crucial for driving widespread adoption, ultimately benefiting millions of individuals by enabling continuous health monitoring and early disease detection. The inclusion of the hop-on partner significantly enhances the research potential of the consortium by providing pathways for the technology’s future development. This collaboration will not only expand the technical capabilities of the project but also enhance the consortium's outreach and access to new talent pools, aligning with WIDERA program expectations. Furthermore, it will enable the widening partner to gain valuable experience in collaborating on transnational research projects, allowing them to accelerate their research in biosensing as part of an international project with clear commercialization goals.

Keywords: laser biosensing,digital biomarkers,vcsels,cardiovascular diseases,kidney diseases