Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Oogenesis spotlighted: making mature human oocytes (OVO-GROWTH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-07-01
End date: 2023-02-28
Duration (months): 68.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

Women who survive childhood cancer often fail to conceive because their eggs are damaged by (gonadotoxic) chemotherapy. A major breakthrough has been the possibility to cryopreserve cortical strips of their ovarian tissue for autologous transplantation later in life. This has led to over 40 successful pregnancies worldwide, the latest in the Netherlands. However, the risk of reintroducing cancer cells with the ovarian graft in patients with previous hematopoietic malignancies is too great and alternatives are needed. Here, I propose to build on my expertise in gametogenesis in mice and humans and perform a detailed study of the cellular networks and molecular pathways that control development and maturation of the oocyte within the human ovary. We have access and ethical approval for research on human foetal tissue and postnatal ovarian biopsies over a wide age range. I will use this rare material to systematically benchmark the transcriptional profile of cells in the human ovary (oocytes as well as somatic cells) during development and adulthood using Drop-seq, a novel cost-efficient single-cell technology that allows the profiling of thousands of cells in a matter of hours. Thereafter, we will apply mathematical algorithms to reveal cellular identities, developmental trajectories and signalling networks that control oogenesis. With this knowledge, I plan to engineer a human follicular niche creating a “mini-ovary” in vitro that could support the formation and maturation of the oocyte (using patient-specific cells) and to explore mechanisms of follicle maturation through a xenotransplantation mouse model. The cellular outcomes of these assays will be sequenced using Drop-seq and directly compared to their in vivo counterparts. Our approach will lead to more effective personalized-therapy for fertility preservation and contribute to the development of an in vitro mini-ovary organoid model to use in human reproductive toxicology and disease modelling.

Keywords: human,oogenesis,single cell transcriptomics,mathematical modelling,reproduction,vasculogenesis,in vitro
Holistic Innovative Solutions for an Efficient Recycling and Recovery of Valuable Raw Materials from Complex Construction and Demolition Waste (HISER)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Enabling the transition towards a green economy and society through eco-innovation
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Spain,Italy,Germany,Belgium,Switzerland,Belgium,Finland,Belgium,Finland,Finland,Finland,Poland,France,France,France,Netherlands,Netherlands,Netherlands,Netherlands
Call: Recycling of raw materials from products and buildings (H2020-WASTE-2014-one-stage, 2014)
Start date: 2015-02-01
End date: 2019-01-31
Duration (months): 48.0
Total project cost (EUR): 7665262.5
EU funding (EUR): 7511870.0
Participants: 29
Project status: CLOSED

EU28 currently generates 461 million tons per year of ever more complex construction and demolition waste (C&DW) with average recycling rates of around 46%. There is still a significant loss of potential valuable minerals, metals and organic materials all over Europe. The main goal of HISER project is to develop and demonstrate novel cost-effective technological and non-technological holistic solutions for a higher recovery of raw materials from ever more complex C&DW, by considering circular economy approaches throughout the building value chain (from the End-of-Life Buildings to new Buildings). The following solutions are proposed: - Harmonized procedures complemented with an intelligent tool and a supply chain tracking system, for highly-efficient sorting at source in demolition and refurbishment works. - Advanced sorting and recycling technologies for the production and automated quality assessment of high-purity raw materials from complex C&DW. - Development of optimized building products (low embodied energy cements, green concretes, bricks, plasterboards and gypsum plasters, extruded composites) through the partial replacement of virgin raw materials by higher amounts of secondary high-purity raw materials recovered from complex C&DW. These solutions will be demonstrated in demolition projects and 5 case studies across Europe. Moreover, the economic and environmental impact of the HISER solutions will be quantified, from a life cycle perspective (LCA/LCC), and policy and standards recommendations encouraging the implementation of the best solutions will be drafted. HISER will contribute to higher levels of recovered materials from C&DW from 212 Mt in 2014, to 359 Mt in 2020 and 491 Mt by ca. 2030, on the basis of the increase in the recovery of aggregates, from 40% (169 Mt) to more than 80% (394 t) and wood, from 31% (2.4 Mt) to 55% (5 Mt);. Similarly, unlocking valuable raw materials currently not exploited is foreseen, namely some metals and emerging flows.

Keywords: complex construction and demolition waste,holistic solutions,efficient recovery,high purity raw materials,novel sorting and recycling technologies,building products,circular building economies
Multilingual Catalonia: factors influencing the multilingual development of societal and foreign languages in school-age children (MultiCat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-12-21
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

How to best promote proficiency in foreign languages, and the role of schooling in doing so, has been a matter of debate in the European Commission for decades. The MultiCat action addresses this debate by investigating the effects of two English learning contexts, English as a foreign language (EFL) and Content Language Integrated Learning (CLIL), on language development during the first year of elementary school in Catalonia, a Catalan-Spanish bilingual province in Spain. In CLIL contexts, students receive extended instruction in English at the expense of reduced hours in Catalan/Spanish. We investigate (1) the effects of the learning context on the development of the three languages and (2) how individual differences between children may influence such development. Special consideration is given to the multilingual development of heritage language children (i.e., children whose home language is not Catalan, Spanish, or English). As such, this action lies at the intersection of three main issues of interest: the development of foreign languages, the protection of minority languages, and the integration of heritage language children. To address our objectives, we will collect data on the oral language and literacy skills in English, Catalan, and Spanish from 600 first graders (ages 5-6) at two time points (at the onset of primary schooling and at the end of the first schoolyear). By determining the effects of the learning context and other sources of individual differences, the results from this action may inform policymakers’ decisions to promote one learning context over the other, and will help other stakeholders make informed decisions about multilingual practices in the school and the home. This action will combine the expertise of the Experienced Researcher, currently a postdoctoral fellow investigating individual differences in bilingual children, and the supervisor, whose research has focused on the effects of CLIL instruction on language development.

Keywords: grammar,vocabulary,literacy,clil
Authoritative Implementation Guidance and International Cooperation to Support Training, Awareness Raising, and Capacity Building (WAI-Guide)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Coordination and support actions
Countries involved: France
Call: New forms of delivering public goods and inclusive public services (H2020-SC6-GOVERNANCE-2018, 2018)
Start date: 2019-01-01
End date: 2022-12-31
Duration (months): 48.0
Total project cost (EUR): 1499742.5
EU funding (EUR): 1499742.0
Participants: 1
Project status: CLOSED

WAI-Guide, Authoritative Implementation Guidance and International Cooperation to Support Training, Awareness Raising, and Capacity Building, drives sustainable impact for more scalable and affordable digital accessibility solutions. WAI-Guide aims to: • Provide authoritative implementation guidance and training, thereby growing capacities of available accessibility experts; • Accelerate tooling support for accessible content authoring, thereby making it more cost efficient to create accessible content; • Identify and address gaps in accessibility standardisation, thereby increasing the coverage of digital accessibility requirements. WAI-Guide achieves these objectives by conducting its work as an integral part of the vendor-neutral environment of the World Wide Web Consortium (W3C). WAI-Guide draws together key expertise from industry, end-user representation, public bodies, research, and other fields, to develop core accessibility solutions that are internationally consensed and recognised as authoritative references. WAI-Guide develops open, royalty-free resources for a variety of audiences, each having a role in digital accessibility. This includes accessibility trainers and educators, consultants and service providers; vendors, developers, and integrators of authoring tools and content management systems; and designers, developers, procurers, project managers, and others involved throughout accessibility implementation processes. WAI-Guide is uniquely positioned and qualified to develop best practices for digital accessibility that are rigorously vetted through the open collaborative W3C Process, and that are harmonised with the authoritative interpretation of the internationally recognised W3C standards for accessibility. WAI-Guide comes at an opportune time to support implementation of the European Directive on Web Accessibility. It strengthens the European Digital Single Market and supports its alignment with global standards on digital accessibility.

Keywords: accessibility,inclusion,digital services
SOciO-eConomiC failurE and aSpiration biaseS (SOOCCESS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Australia,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-10-19
End date: 2023-10-18
Duration (months): 36.0
Total project cost (EUR): 277940.16
EU funding (EUR): 277940.16
Participants: 2
Project status: SIGNED

From early childhood, many poor children brought up in segregated communities observe socio-economic failures such as poor living conditions, liquidity constraints, extremely high unemployment and low education levels attained by adults. Enhancing their aspirations is believed to be a tool capable of breaking one of the poverty feedback loops: poverty has been identified as a cause of the failure to aspire to one’s own potential, and at the same time, low aspirations are among the potential causes of persistent poverty. Consequently, adolescents from areas of high deprivation are generally believed to have low aspirations, though, in fact, their aspirations vary considerably, and may be generally high. This signals two main aspiration biases: aspirations failure and aspirational gap. This project is aimed to investigate how stimulating success/failure environments can reduce aspiration biases of the segregated poor, which, according to theory, should increase their chances to escape the poverty trap. The project has an interdisciplinary character: it is aimed to investigate the psychological construct of aspirations in the economic context in educational environments. Using cutting-edge methods from behavioural and experimental economics, we will experimentally investigate to what extent exposure to success/failure environments will lead to a significant decrease/increase in aspirational biases. From the methodological perspective, we will first design a novel approach to the experimental elicitation of aspirations, then we will design an experiment manipulating success/failure to assess their effects on aspirations. From the empirical viewpoint, using experimental data, the project will shed new light on the relationship between socio-economic background and aspirational biases, and thus test the predictions of economic theory. To address the concern of external validity, the proposed experiments will be conducted in different cultural settings.

Keywords: aspirations,poverty,segregation,minorities
Exploring Subtitle Reading Process with Eyetracking Technology (SURE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-15
End date: 2018-07-14
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Subtitling is part and parcel of today’s world. It is used not only by people who do not know the language of the original soundtrack, but also by those requiring different means of accessing audiovisual content due to sensory impairments, caused by deafness, hearing loss or ageing. While the main goal of subtitling is to foster access to multimedia content, its quality often falls short of users expectations and may be insufficient for them to take full advantage of what they read. Among the most problematic issues in subtitling quality are optimum presentation rates and subtitle layout. Subtitlers are faced with lack of research data to support their current practices with, which results in lack of uniform standards on reading speed, inconsistent layout and poor quality subtitling. The central aim of this project is to experimentally study the subtitling reading process with a view to establishing subtitle quality indicators regarding optimum presentation rates and layout. The study of subtitle processing is of fundamental importance in understanding how people perceive subtitled video materials in a digital society that increasingly relies on the exchange of audiovisual material. The study will be conducted at the Centre for Translation Studies at University College London, the world-leading centre of audiovisual translation, directed by Prof. Jorge Díaz Cintas, the scientist in charge of this project, in cooperation with the Deafness Language and Cognition Research Centre at UCL, directed by Prof. Bencie Woll. London is also the commercial hub of the audiovisual translation industry, which is relevant to this study as it will be conducted with direct links to the industry through secondment. This project is not only directly applicable to current market practices and will benefit end users, but it also addresses EU challenges of multilingualism, accessibility, ageing and education.

Keywords: subtitling,eyetracking,audiovisual translation,reading,media accessibility,subtitling quality,subtitle presentation rate,subtitling for the deaf and hard of hearing,closed captions
Assessment of Performance in current ATM operations and of new Concepts of operations for its Holistic Enhancement (APACHE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Spain,Serbia,France
Call: ATM Performance (H2020-SESAR-2015-1, 2015)
Start date: 2016-05-09
End date: 2018-05-08
Duration (months): 24.0
Total project cost (EUR): 783837.5
EU funding (EUR): 783837.5
Participants: 4
Project status: CLOSED

The APACHE project proposes a new framework to assess European ATM performance based on simulation, optimization and performance assessment tools that will be able to capture complex interdependencies between KPAs at different modelling scales (micro, meso and macro).In this context, the purpose of APACHE is threefold: - to evolve the Performance Scheme towards new methodologies and metrics capable of capturing with proportional detail the performance drivers of ATM to foster a progressive and performance-driven introduction of new operational and technical ATM concepts in line with SESAR; - to make an (initial) impact assessment of long-term ATM concepts with the new APACHE Performance Scheme, to measure the impact on ATM KPAs under different assumptions in line with the SESAR ConOps 2020+; and - to analyse the interdependencies between the different KPAs at the Pareto-frontier of the ATM performance, by finding the theoretical optimal limits for each KPA and assessing how the promotion of one KPA may actually reduce the performance of the other KPAs An initial performance assessment of new concepts of operations will be required, covering the new concepts t: free-routing in 2D (2DFR) and in 3D (3DFR) for airline operators; dynamic airspace configuration (DAC) for air navigation service providers (ANSPs); and dynamic demand and capacity balance (dDCB) for the Network Manager (NM). All these concepts will be analysed at EU-wide and/or functional airspace block (FAB) level combined under different scenarios and case studies. The optimization tools will be used to model the ATM performance drivers underpinning each of the the stakeholder’s business models, in particular regarding the optimization of processes for aircraft trajectory planning, sectorization planning and network safety planning. Assessment tools will be used to measure the level of KPA performances in the simulations. Tools will be provided by partners and initial versions are already available.

Keywords: performance,simulation,free flight
Reservoir Computing with Real-time Data for future IT (RECORD-IT)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Israel,Switzerland,Switzerland,Poland,Croatia,Sweden,France
Call: FET-Open research projects (H2020-FETOPEN-2014-2015-RIA, 2014)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 4193147.5
EU funding (EUR): 4193147.25
Participants: 9
Project status: CLOSED

The aim of this proposal is to develop an intelligent biocompatible sensing device which detects complex behavioural changes in ion concentrations. The sensor will use wet NOMFETs, coated Si nanowires, self-conjugated polymers, arrays of photocells, flow of lipids. The level of ions will be measured by monitoring changes in the response function of the system. The high sensitivity of the device will be achieved by ensuring a strong coupling between the environment and the device. The key research challenges will be: accessing the feasibility of the idea to use reservoir computing for sensing complex environmental changes, identifying suitable integration strategies for the components, optimizing the sets of input/output pairs (response functions) and the device components for enhanced sensitivity.

Keywords: reservoir computing,pattern recognition,biological scale sensors
TIGIT therapy for cancer treatment (TIGITtherapy)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-07-01
End date: 2018-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Treating tumors with immune-related therapies is one of the most exciting and promising advancements made in the past decade. Cancer immunotherapy drugs have captured nearly 50% of the overall oncology drugs market. TIGIT is an important checkpoint inhibitory receptor discovered by our group in 2009. It is constitutively expressed by various immune cells and its expression is further increased on tumor infiltrating lymphocytes (TILs). TIGIT recognizes two main ligands, PVR and Nectin2 that are highly expressed on various tumors. Blockage of TIGIT on TILs either alone or in combination with another checkpoint inhibitory receptor, PD-1, leads to increased T and Natural Killer (NK) cell activity in vitro and inhibited tumor growth in vivo. We developed 9 different anti-TIGIT mAbs during my BacNK ERC advanced grant and previously. In the POC grant TIGITtherapy, which already attracted interest from several bio pharma companies, I propose testing which of the 9 anti-TIGIT mAbs and TIGIT-Ig are able to antagonize TIGIT activity.

Keywords: tigit,antibodies,tumors