Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dismantling, REdialing, personalizing, and implementing task SHIFTing psychosocial interventions to treat and prevent common mental disorders in low-resource settings (RE-SHIFT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 273943.2
EU funding (EUR): 273943.2
Participants: 2
Project status: SIGNED

RE-SHIFT focuses on preventing and treating common mental disorders in people living in low-resource settings. It aims at (a) dismantling psychosocial interventions delivered by non specialist providers into their components, (b) evaluating each component efficacy and redialing the most effective components into a novel task shifting psychosocial intervention, and (c) implementing findings through a worldwide coverage e-learning platform. RE-SHIFT will also develop a publicly available calculator to estimate the efficacy of each component based on individual participant characteristics. Starting from an analysis of individual participant data from all randomized controlled trials conducted in the field of global mental health available on the matter, RE-SHIFT will pioneer a sophisticated study design to unravel which components work best and for whom, identifying at the same time how participant, provider and delivery characteristics moderate the outcome and how beneficial effects of the psychosocial task shifting interventions are mediated. With this information it will be possible to tailor interventions according to the specific needs of diverse populations, allowing the "RE-SHIFTing" of available resources to the best of their use. A mainstay of RE-SHIFT is to activate ambitious implementation and dissemination measures to let a different range of stakeholders, lay people, organizations, general public, patient and family organization advocates to know about the project, its aims, deliverables, and potential impact of its findings on the society. Training activities will last for the entire duration of the project, and results will be presented in top-tier international conferences and submitted to high impact factor international peer-reviewed journals. RE-SHIFT is concrete and ambitious, its findings will be globally applicable and serve as a blueprint and impetus for other projects aiming at promoting mental health equity.

Keywords: global mental health common mental disorders prevention treatment task shifting psychosocial interventions low resource settings
SUPASO Modular Upcycling Hubs (SUPASO MUCH) (SUPASO MUCH)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Austria
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 1900000.0
EU funding (EUR): 1900000.0
Participants: 1
Project status: SIGNED

SUPASO aims to revolutionize the sustainable packaging market by developing the micro-factory SUPASO ecoliner machine, a MaaS-solution, for the decentralized in-house production of packaging insulation elements directly from cardboard waste and other paper streams which can be implemented in the facilities of a client. Also, regional communities will be addressed and supported through Modular Upcycling Hubs (MUCH) throughout Europe. We are committed to advancing the sustainable packaging solutions field by bringing it to the spotlight and building an ecosystem of stakeholders in the field. In SUPASO, we will work with strong partnerships to provide new innovative sustainable packaging solutions. We aim to have a high impact on society and the environment by providing new sustainable packaging innovations that empower companies and individuals to reduce the environmental impact of packaging waste. We are actively working to expand our reach, aiming to make a tangible difference in cardboard waste and paper upcycling and consequently in the environment. Our SUPASO Ecoliner machine is revolutionary in terms of process and technology, negating the need for outsourcing the production of insulation packaging materials and reducing paper and cardboard waste on-site in the logistics, manufacturing, wholesaling, paper production, and retail industries. We do this whilst utilizing the existing cardboard waste to create an upcycled, custom-fitted product which can be used in packaging and delivery for thermal and shock protection, two elements which are crucial in many industries. It is based on more than 10 years of research and development, among others with the Fraunhofer Institute for Material Flow and Logistics in Dortmund, the Technical Paper Foundation of Germany, as well as the University Applied Science of Upper Austria (Logistics Department).

Keywords: sustainable packaging,packaging waste,upcycling,sustainability,eu packaging regulations,cellulose paper fibre,micro factory,ai driven manufacturing process,styrofoam,machine as a service
A minimally invasive and durable endograft fastening solution for Abdominal Aortic Aneurysm (AAA) (aortoseal)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-02-01
End date: 2025-07-31
Duration (months): 30.0
Total project cost (EUR): 6046607.5
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

Abdominal aortic aneurysm (AAA) is a focal enlargement of the abdominal aorta below the renal arteries and is found in up to 4 million patients globally each year. If left untreated it can be fatal, so it is imperative to provide early, prophylactic treatment before a rupture occurs. The available treatment options are far from optimal: open surgery is a durable, life-long, but high-risk solution. The alternative, EVAR, has lower immediate risks, but is a shorter-term solution and requires continual monitoring and secondary interventions. We have developed Aortoseal, a fixation and sealing implant for endovascular aneurysm repair that combines the best of both worlds: the stability of an open, sutured repair and the safety and low-risk delivery of EVAR. Aortoseal will reduce the need for open surgery, the need for secondary procedures and time in the hospital, all leading to improved patient outcomes and projected healthcare savings over a 10 year period of ~€9 bn across the EU.

Keywords: endograft,endovascular repair,abdominal aortic aneurysm,clinical trial,surgery
PHYCOCARE The natural algae-based solution to decrease Chemotherapy Induced Peripheral Neuropathy for patients suffering from cancer (PHYCOCARE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 2100000.0
EU funding (EUR): 2100000.0
Participants: 1
Project status: SIGNED

AlgoSource has developed a microalgae extract that is effective in decreasing Chemotherapy Induced Peripheral Neuropathy (CIPN): PHYCOCARE. There is currently no solution for CIPN prevention. They have an impact on the nerves and the brains and occur in more than 50% of the patients treated with certain chemotherapy (oxaliplatin, taxanes…). CIPN are so aggressive that in 40% of the cases the treatments must be decreased or interrupted when the patients can no longer bear them. The reduction of oncology side effects using PHYCOCARE has been observed by several oncologists in France, on human and on animals since 2016. These empirical results have been supported by the demonstration in 2018 of the strong antioxidant activity of the product gained in the PHASE I clinical study SPIROX (double blind against placebo) on 40 subjects. On this basis the HOSPITAL of Nantes has been convinced to sponsor a PHASE II clinical study, to demonstrate a 50 % reduction of CIPN (see Letter of Support in Annex). The study involves 8 hospitals in France and is halfway through completion. AlgoSource’s project is to develop PHYCOCARE as a worldwide solution to prevent CIPN. More than 125 000 people are suffering from CIPN only for digestive cancer in Europe each year. Similar proportion of people are affected in North America and China. Algosource aims at supporting those people with a patented natural product, clinically evaluated. Based on a patented water-based extraction process, coupled with a long experience in microalgae cultivation, AlgoSource has developed a unique production process that is both natural and sustainable. Using PHYCOCARE as the flagship solutions for supportive care applications, AlgoSource’s ambition is to develop a line of products effective in bringing patients a better quality of life and the chance to better comply with their treatment. That is AlgoSource’s vision: microalgae for Health.

Keywords: nutraceutical neuropathy chemotherapy microalgae
Probing the cell ion channels with functionalized Atomic Force Microscopy tips and electrodes tested on biomimetic membranes embedding ionophores (ProBIOnCell)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Romania
Call: ERA Fellowships (HORIZON-WIDERA-2023-TALENTS-02, 2023)
Start date: 2024-09-02
End date: 2026-09-01
Duration (months): 24.0
Total project cost (EUR): 149575.68
EU funding (EUR): 149575.68
Participants: 1
Project status: SIGNED

The main goal of ProBIOnCell is to broaden my expertise by performing state-of-the-art scientific research in the fields of applied physics and cell biology by implementing functionalized AFM tips with natural and/or synthetic ionophores incorporated into biomimetic membranes, for electrochemically testing their ability to detect target ions in cellular cultures, so that to probe and localize cell membrane ion channels, gap-junction and focal adhesion on mouse primary cardiac fibroblast cells. Advancing the characterization of biological cells allows for a deeper understanding and modeling the physiological behavior of biological tissues, with huge potentials in biomedicine for improving the management of cardiovascular diseases and their treatment. From a personal perspective, this project contributes to my first international mobility, which is fundamental for unlocking new career perspectives towards a permanent research position and will be implemented at the National Institute of Materials Physics (NIMP) of Bucharest. In order to achieve the main goal of ProBIOnCell some specific objectives are foreseen: O1. Membrane synthesis and ionophores incorporation. Bilipid membranes, hydrogels and liposomes will be synthesized and the incorporation of ionophores investigated. O2. Functionalization of electrodes and AFM tips. This objective involves the deposition or bottom-up construction of the membrane with embedded ionophores at the surface of electrodes and AFM tips. O3. Development of suitable control healthy and pathological fibroblast cell cultures, test the membrane capacity for the detection of target ions by electrochemical methods in the absence and in the presence of inhibitory compounds, and localize ion channels, gap junctions, and focal adhesions by AFM.

Keywords: applied physics,atomic force microcopy afm,cell receptors,ion channels,functionalization,ionophores,cell communication,biochemistry,molecular biology,biophysics
First time ultra-sensitive and simultaneous quantification of proteins, interactions, and post-translational modifications in single cells to enable exponential growth in proteomics and interactomics (PICO-NGS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-08-01
End date: 2025-07-31
Duration (months): 24.0
Total project cost (EUR): 3568750.0
EU funding (EUR): 2498125.0
Participants: 1
Project status: CLOSED

In a human cell there are about 20k protein coding genes (genome) that originate ~100k proteins (proteome). Proteins are involved in complex networks of protein-protein interactions (PPIs) influenced by post-translational modifications (PTMs), the interactome of living cells (~800,000 entities). The genome is mostly static throughout cell lifetime and can be sequenced today in <1h. The proteome and interactome are changing with e.g., environment and health, and not yet fully known. Today's methods for proteomics and interactomics are tedious, and lack sensitivity, quantitativity and parallelism. PICO-NGS combines ultra-high sensitivity (>10 fM) with high parallelism measuring proteins, PPIs, and PTMs simultaneously (>50 targets). This will disrupt the global proteomics market (€29 B worth, 16% CAGR). This will fertilise ground-breaking academic research and accelerate developments in e.g., Pharma (drug discovery), Biotech (biomarkers/diagnosis), and Agrotech (crop sciences) industries.

Keywords: proteomics,dna identifiers,next generation sequencing,biological pathways,immunoassays,posttranslational modification of proteins,interactomics,digital assays
ZERO-EMISSION CONTROL AND MONITORING INTERFACE FOR MARITIME OPERATIONS (DEECEE INTERFACE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Propulsion House Pulling-e (PHPE), aims to redefine maritime industry with its innovative DeeCee Microgrid™. Leveraging over 25 years of expertise in sustainable maritime operations, PHPE seeks to address the urgent need to reduce greenhouse gas emissions in the maritime sector, driven by stringent EU regulations such as the FuelEU Maritime proposal and the IMO’s new frameworks. PHPE’s DeeCee Microgrid™, offers a novel approach to vessel electrical power management system, enabling significant weight and space savings, crucial for the adoption of alternative fuels. The system is designed to be implemented in both new builds and retrofits, targeting the underserved market of medium-sized vessels. PHPE’s innovations support global sustainability goals, particularly in reducing maritime CO2 emissions, aligning with several UN Sustainable Development Goals and the EU’s climate targets. The company is poised to drive industry-wide adoption of zero-emission technologies.

Keywords: zero emission maritime,microgrid,maritime,refit,ghg emission reduction,electrical system,propulsion motors,sea vessels
Neuromorphic Quantum-Inspired Optimization and Simulation (NEQIOS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands,Germany,Switzerland,United Kingdom
Call: EIC Pathfinder Open (HORIZON-EIC-2025-PATHFINDEROPEN, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 3358894.25
EU funding (EUR): 3333894.25
Participants: 6
Project status: SIGNED

NEQIOS introduces a radically new approach to solving complex computational problems that resist efficient solution on existing digital or quantum systems. We propose a compact neuromorphic platform that physically emulates key quantum properties, such as annealing, tunnelling, and superposition, without relying on fragile quantum states. Instead, NEQIOS integrates analogue in-memory computing (AIMC), integrated photonics (IPC), and reconfigurable nonlinear computing (RNC) in a high-performance system-on-package design. This innovation is urgently needed. From materials discovery to logistics and drug design, society faces NP-hard problems that scale exponentially. Quantum computers offer promise, but current systems – operating at cryogenic temperatures and requiring large infrastructure – remain costly, slow, difficult to scale and prohibitive for use on edge devices. NEQIOS offers a robust, room-temperature alternative that drastically reduces energy use (below 1 mW) and solution time (microseconds), while achieving solution quality on par with quantum annealers. NEQIOS’s key breakthrough lies in decomposing energy-based models into fine-grained computational primitives, each mapped to a dedicated physical substrate. AIMC performs high-throughput vector-matrix operations, IPC ensures precision and low-latency signal flow, and RNC handles nonlinear, adaptive function approximation. Together, these components form a physical solver capable of mimicking quantum behaviour with unmatched efficiency and scalability. NEQIOS is driven by a world-class European consortium with deep expertise in neuromorphic computing, photonic hardware, and analogue systems. With IBM Research Europe, Radboud University, University of Heidelberg, Enlightra, University of Oxford, and University of Twente, we unite technical excellence and a bold vision to deliver a transformative computing paradigm, aligned with Europe's semiconductor strategy and future demands in AI, science and industry.

Keywords: neuromorphic computing quantum inspired optimization analogue in memory computing aimc integrated photonics for computation energy based models reconfigurable nonlinear hardware
A PROactive approach for COmmunities to enAble Societal Transformation (PRO-COAST)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Germany,Cyprus,Greece,Spain,United Kingdom,Italy,Norway,Estonia,Slovenia,Romania,Montenegro,Malta,Belgium,Ireland
Call: Understanding the role of behaviour, gender specifics, lifestyle, religious and cultural values, and addressing the role of enabling players (civil society, policy makers, financing and business leaders, retailers) in decision making (HORIZON-CL6-2022-BIODIV-01, 2022)
Start date: 2023-11-01
End date: 2026-10-31
Duration (months): 36.0
Total project cost (EUR): 3285362.5
EU funding (EUR): 3285362.5
Participants: 20
Project status: SIGNED

PRO-COAST will develop, apply and validate a cutting-edge operational framework in the study of coastal ecosystem dynamics for the benefit of the population most exposed to risk deriving from biodiversity loss. Such a framework needs to tackle the complex social-ecological issues at hand, particularly so because these issues involve a dynamic perspective on the social as well as its interaction with the ecological system. Hence, the PRO-COAST framework will be based on the integrative Social Ecological Systems framework (SESF), based on the seminal work of the late Nobel Laureate Elinor Ostrom. PRO-COAST will apply and validate its holistic framework for identifying the interactions and dynamics of the different subsystems in a set of nine representative case studies located on the European continent, both in EU and non-EU areas, covering all five European coastal regions. The coastal ecosystem is the common thread running through all the case studies, but each one presents a specific issue and framework. In each case study we will co-create together with local stakeholders a set of tools and policies for the successful implementation of biodiversity conservation projects. Two approaches (the Bristol Approach & the Extreme Citizen Science (ECS) framework) to co-creation will be used to develop and establish a participative approach, which is, by virtue, responsive to local contexts. In line with PRO-COAST’s overall objective to increase capacity and resilience within the transformative communities a change process will be initiated, taking into account technical and social capacity. While the technical side of the change comprises new technologies and services regarding biodiversity, the social side of the change focuses on the human’s openness and readiness for change. To achieve its goals, PRO-COAST brings together 20 organisations across 14 different countries, selected on criteria of experience, expertise and most of all complementarity and interdisciplinarity.

Keywords: biodiversity conservation,ecosystem services,coastal ecosystems,transformative change,civil society,socio ecological systems,nbs,stakeholder engagement,behavior change,indirect drivers