Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Heterogeneous Single-Atom Catalysts for Carbon Dioxide Reduction to Chemicals (SACforCO2)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,Belgium
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-12-01
End date: 2025-01-31
Duration (months): 26.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 2
Project status: CLOSED

The increase in global energy consumption has been relentless as a consequence of population growth, higher living standards, and industrial expansion. This has caused, in turn, acute problems with the release of vast amounts of carbon dioxide (CO2) into the environment, which is linked to ocean acidification, global warming and extreme weather conditions. Finding new routes to strategically capture, mitigate, and utilize CO2 is thus a priority. The catalytic conversion of CO2 to chemicals is a promising pathway for transforming this “waste” into a precious platform molecule, but the approach is still in its infancy. The SACforCO2 project will decisively contribute towards this effort by designing a novel class of single-atom catalysts (SACs) for a new purpose: the conversion of CO2 to make higher alcohols. To this end, SACforCO2 will adopt an interdisciplinary approach which combines organoligand-based synthesis, advanced characterization, and a close synergy between experimental and theoretical research to gain a deep understanding of the N-based surface functionalization that guides single atom anchoring. By integrating SACs into 3D printed membranes, the project will also set up the technology for a cost-effective conversion of CO2 to chemicals. This will provide fresh perspectives in catalyst design and build bridges between fundamental efforts on materials and device engineering, achieving breakthrough performance under realistic conditions. Furthermore, this action will establish an intra-European interdisciplinary network between emerging researchers in academia and industry, at POLIMI (Italy) and VITO (Belgium), and will allow an Experienced Researcher to consolidate a diverse set of scientific and soft skills, gaining cutting-edge research competences, new credentials in teaching and supervision, and the possibility for collaborations with a broad EU network. This will ultimately strengthen career prospects toward a scientific independence.

Keywords: flow chemistry,heterogeneous catalysis,single atom catalysis,green chemistry,co2 reduction,technical chemistry,chemical engineering,applied chemistry
Ultrastructural analysis of mutant Huntingtin fibrils extracted from human brain tissue using high-resolution bioimaging and proteomics methods. (HUNTING-BrainFibrils)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2026-07-31
Duration (months): 35.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

The formation of protein fibrils in the brain is the most representative feature of neurodegenerative diseases. A detailed description of their structure and composition is essential to design new therapeutic approaches that allow patients to increase their life expectancy and quality of life. In Huntington’s disease (HD), the severity of the symptoms and the age of onset is strongly dependent on the number of glutamines above the threshold carried by the huntingtin protein of patients affected with this disorder. The two main objectives of this project are 1) to obtain atomic models of soluble and insoluble fibrils extracted directly from the brain tissues of individuals carrying extreme and moderate CAG repeats in the HTT gene and 2) mapping their in-situ interactions. Our approach will include state-of-the-art cryogenic electron microscopy, mass spectrometry-based proteomics and immunology. It will count on the participation of an interdisciplinary research group, comprising experts in HD pathology, structural biology and interactomics. The host institution counts with advanced facilities in image data analysis, cryo-EM and high-throughput proteomics that will be fully available. The host lab is an internationally recognised group that has more than 20 years of experience in carrying research focused on the molecular causes of HD in cell and animal models. It also has a strong background in mapping the interactions of the proteins that cause neurodegeneration in brain tissues. The host lab will take advantage of my expertise in assessing and validating protein-protein interactions through biochemical and biophysical methods. My visibility as a researcher will be greatly benefited by the extensive collaboration network of the host lab. The training and skills acquired during the execution of this project will expand and consolidate my research career and bring it to a very competitive point for taking a leading role as an independent researcher.

Keywords: neurodegeneration,brain fibrils,huntington s disease,amyloid fibrils,proteomics
Returns to Work in Occupational, Relational, and Corporate Settings (ReWORCS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1497986.0
EU funding (EUR): 1497986.0
Participants: 1
Project status: SIGNED

The rise of platforms and remote work has refashioned concerns about work security and flexibility in public debates. Academic studies have documented an increase in non-standard work over decades, including polarization of rewards, shifting occupational boundaries, and winding paths among women and other marginalized groups. These findings had important policy implications but left questions about the unfolding of individual labor market experiences amid the more noticeable changes. This project mobilizes new techniques and data sources and overcomes divisions in research on work to address those problems. It will recover important complexity by (1) measuring the diversity of individual job trajectories in light of their economic returns, costs, and risks and by (2) grounding job trajectories in work activities and, crucially, workers’ interpretations of labor market structures. These objectives integrate previously divided formal and constructionist thinking to explain the interplay of contexts, practices, and meaning around work. The project has three parts. Work package 1 (WP1) uses national-level employment datasets of France, Germany, and the US to survey job trajectories in relation to earnings across institutional contexts. It advances analyses of occupational and other categorical effects by drawing attention to job change sequences, standard and odd. WP2 asks how workers organize concrete work. It takes two strategic cases with detailed work records, one involving technical expertise and the other practical tasks, to study how workers do their jobs as they move between corporate and relational arrangements and to what effects. Both steps assume stable structures. WP3 asks how workers question conventional job presentations in standard and non-standard work trajectories. It draws on a unique dataset of career descriptions in two areas of work and two countries to capture institutional and cultural effects on meaning construction.

Keywords: labor markets expertise meaning practice organizations computational social science social network analysis text analysis
Electrified Liquid-Liquid Interfaces Supported in 3D Printed Platforms for Rapid Detection of Benzodiazepine Date Rape Drugs (e-gainstRapeDrugs)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Poland
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 139953.6
EU funding (EUR): 139953.6
Participants: 1
Project status: CLOSED

The main objective of this work is to develop simple sensing solutions for benzodiazepines (BDZ, date rape drugs) detection. The outcomes of this project are expected to be visible to citizens as the fully functional sensing solutions. Proposed innovation is a resultant of three main streams: (i) 3D printing for the sensors development, (ii) comprehensive electroanalysis of BDZs at the electrified liquid-liquid interface (eLLI), and (iii) very meticulous electroanalytical screening focused on BDZ and co-existing interfering species (defined based on target real samples). BDZ are psychoactive species renowned for their ability to induce sedation, aid sleep and are prescribed to treat a range of clinical conditions (e.g. anxiety). Some BDZs and their structural analogues are classified as illicit drugs and are subjected to strict control. The combination of BDZ and alcohol was mostly related to drug-facilitated crimes such as sexual assaults. Due to related health and economic issues caused by BDZs it is necessary to strengthen their on-the-spot detection. This project will develop eLLI based analytical tools to evade BDZ related social crimes and health hazards. 3D printing will be used to create sensing platforms that can be utilized on the spot. Further, the solutions proposed in this proposal are expected to be fully applicable for the presumptive analysis of BDZ drugs by non-expects and possess commercial opportunities for widespread adoption. The adviser and the researcher bring complimentary experience in the domains of eLLI and electrochemical sensors. Moreover, the goal of this project is to enhance the innovative potential of researcher who wish to acquire new skills through advanced training, mobility, new environment, and who is seeking to continue his career in research. MSCA guidelines on supervision Will be followed to foster soft and hard skills of researcher, willing to contribute to solving the challenges defined by the MSCA Green Charter.

Keywords: date rape drugs,benzodiazepine,psychoactive drugs,electrochemical sensors,drug facilitated crimes
Quantum Memory interface based on multicolor unconditional quantum teleportation (EPRoxy)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2025-09-30
Duration (months): 18.0
Total project cost (EUR): 161200.8
EU funding (EUR): 161200.8
Participants: 1
Project status: SIGNED

Quantum Memories are crucial technologies in Quantum Communications infrastructures. The ability to store and retrieve quantum information can simplify a complex process and increase the flexibility of current communication networks. For this reason, different quantum systems are currently being investigated to produce stable and reliable quantum memories(CITE). Despite their potential, the practical application of these technologies is hindered by intrinsic limitations in their read/write process which is generally based on an optical link. This coupling depends on the specific phenomenon used to store the quantum information, and it imposes stringent requirements on the optical wavelengths used as interface. As a result, two issues arise: Firstly, it's not feasible to connect quantum memories with incompatible wavelengths, and secondly, most quantum memories cannot be integrated with standard communication channels. Thus, implementing Quantum Memories in real-case applications requires developing a new writing/reading approach to overcome this constraint. In this project, I will demonstrate that unconditional quantum teleportation can overcome the wavelenght requirement. This communication protocol uses both a quantum and classical channel to transfer quantum information between two distinct systems. By employing a two-colour Einstein-Podolsky-Rosen (EPR) vacuum-squeezed entangled state as the quantum channel, we can restrict the quantum memory's constraints to just one side of the connection, enabling us to choose the second wavelength based on the external device. I will carry out this project in collaboration with the Danish Center for Quantum Optics (Quantop) led by Prof. Eugene Polzik at the University of Copenhagen (UCPH).

Keywords: quantum communication multicolor unconditional quantum teleportation quantum memories atomic spin ensemble matter light interaction hybrid system
Organization of long-range inputs in sensory cortex for top-down modulation of tactile perception (FBIimaging)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2025-12-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: SIGNED

The sensory cortex plays a crucial role in detecting and interpreting environmental stimuli. Tactile inputs from the peripheral organs are transmitted through the thalamus to the primary somatosensory cortex (S1), where they are integrated with long-range projections from higher-order brain regions, defined as feedback (top-down) inputs. Top-down control has been proposed to mediate contextual or attentional modulation of sensory processing. The host laboratory has shown that layer 5 pyramidal neurons (L5-PNs) in S1 exhibited dendritic regenerative potentials, so-called calcium spikes, when mice detect tactile stimuli, and their manipulation altered the mouse’s perception threshold. Interestingly, the L5-PN’s distal-apical dendrites, where calcium spikes originate, are extensively innervated by axonal projections from higher-order cortical and thalamic areas. In light of this evidence, I hypothesize that long-range inputs to S1 modulate tactile detection via facilitating dendritic calcium spikes in L5-PNs. To test this hypothesis, I will determine the localization and timing of the long-range feedback inputs reaching the apical dendrites of S1 L5-PNs, which covary with the tactile detection sensitivity. Furthermore, I will test the context dependence of the long-range inputs. I will employ a whisker detection paradigm, where mice are trained to detect single whisker deflections to obtain water rewards. I will combine one-photon wide-field imaging and state-of-the-art genetic tools to visualize the glutamatergic inputs in distal dendrites or the axonal calcium activity in long-range projections. My study will provide new insights into the neuronal mechanisms underlying contextual modulation of perception by shedding light on the integrative properties of cortical pyramidal neuron dendrites.

Keywords: somatosensory cortex dendrite long range projection in vivo imaging tactile detection dendritic spines synapses
Industrialising eSMR to Supply the Next Shipping Fuels (NextFuel)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Norway,Denmark,Greece,Netherlands
Call: Demonstration of advanced biofuel technologies for aviation and/or shipping (HORIZON-CL5-2023-D3-01, 2023)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 12238728.63
EU funding (EUR): 8999095.0
Participants: 7
Project status: SIGNED

The basis of our innovation is to pilot a novel approach to producing methanol, never before piloted beyond our project partners lab scale prototype, where we use an electrically heated stream methane reformer (eSMR) instead of present firing of natural gas in the fired reformer (used in conventional methanol synthesis). The scientific background of the innovation is solid. We have a successful lab prototype and many publications describing parts of the work in journals including Science. The eSMR technology can allow very compact reactor designs, up to 100 times smaller than current SMR plants, which combined with higher energy efficiency and no directly associated CO2 emission, makes the eSMR reactor extremely commercially attractive for synthesis gas production. The technology is also well suited to add additional hydrogen and CO2 to increase production. The cost-efficient (we target a similar cost level as biogas) and scalable (in addition relevance or thousands of biogas sites, we can scale through adding hydrogen and CO2) solution can be built as a realistic alternative to fossil methanol production. In the project Topsoe delivers the process plant to Gasnor (both a biogas owner and Norway´s largest provider of LNG) that in turn want to market sustainable ship fuels. We have a first customer in the project, that are currently building two feeder container vessels running on methanol (one of Europe´s leading ship owners Wilhelmsen, participating through their sustainable shipping unit TOPEKA). With the assistance on leading research groups covering both optimizing resource streams (NTNU) and ecosystem simulations (CERTH), we develop a comprehensive plan to pathways of bringing eSMR-based plant designs to efficient and widespread use in Europa.

Keywords: bio methanol methanol shipping
Opioid-free Pain relief for Enhanced Recovery After Spine fixation surgery (OPERAS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-04-01
End date: 2026-03-31
Duration (months): 36.0
Total project cost (EUR): 5687678.5
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

There is a troubling lack of effective pain treatments after major surgery. Especially after musculoskeletal procedures, patients experience debilitating pain now treated with opioids. Opioids provide insufficient pain relief, have many toxic side-effects, and are highly addictive. Pain and opioid-related side-effects impede early mobilisation and recovery and are the primary reasons for extended hospital stays. SentryX is developing revolutionary drug delivery technology to extend the effects of a well-established local pain blocker called bupivacaine. Its initial use case in spine fixation surgery, Bupi-Ring, delivers bupivacaine directly to the surgical site for more than 72 hours without changing the existing surgical workflow. Non-opioid local pain relief in this critical early phase of recovery will promote early mobilisation, shorten hospital stays, prevent complications, and save costs. This project will demonstrate Bupi-Ring’s safety and efficacy in humans for the first time.
Decoding the Mechanisms Underlying Metal-Organic Frameworks Self-Assembly (MAGNIFY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 1340375.0
EU funding (EUR): 1340375.0
Participants: 2
Project status: SIGNED

Metal-Organic Frameworks (MOFs) are porous materials with many societally relevant potential applications, such as carbon capture, removal of environmental toxins and drug-delivery. Despite the progress in the field, synthesizing a MOF currently requires tens to hundreds costly and time-consuming trial-and-error synthesis experiments because our ability to correlate the synthesis conditions with the desired MOF structure is very limited. To overcome this, we need to decode the mechanisms underlying MOF self-assembly, a highly complex non-equilibrium process covering a wide range of time- and length-scales, from the formation of the building units to nucleation and growth. In MAGNIFY, my team and I will develop a multi-scale computational methodology that will decode the mechanisms underlying MOF self-assembly and predict synthesis conditions-structure relationships. This ambitious interdisciplinary project combines state-of-the-art multi-scale modelling techniques (enhanced sampling techniques, ab initio, atomistic and coarse-graining modelling), with machine-learning approaches to data analysis (dimensionality reduction and data clustering techniques) trained on new chemical descriptors. We will develop and validate our models in tandem with synthesis experiments. We will test our methodology by applying it to two central problems in MOF rational design: (i) determining how synthesis conditions (temperature, solvent, reactants, metal-to-ligand ratio, additives) drive the resulting MOF material's topology and point defects, as well as to (ii) tackling the very challenging task of predicting the synthesis conditions for producing brand new MOFs. This high-risk high-gain project will produce a breakthrough in the MOF field by enabling fast and resource-efficient MOF rational design and will open new research avenues in investigating the self-assembly of other materials and other complex processes happening through a large span of time- and length-scales.

Keywords: multi scale modelling,enhanced sampling,self assembly,molecular dynamics,machine learning,coarse graining,metal organic frameworks,experiment modelling synergy,nucleation and growth,mechanisms,synthesis conditions structure relationships,rational design,synthesis of metal organic frameworks,crystal growth,in situ and ex situ characterisation