Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Rhodoshop – a pilot programme to facilitate investment in energy efficiency by creation of One-Stop-Shop in Rhodope Region of Bulgaria. (Rhodoshop)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Bulgaria,Bulgaria
Call: Project Development Assistance (H2020-EE-2016-CSA, 2016)
Start date: 2017-09-01
End date: 2022-08-31
Duration (months): 60.0
Total project cost (EUR): 470550.0
EU funding (EUR): 470550.0
Participants: 2
Project status: CLOSED

Rhodoshop project aims at assisting local public authorities and other stakeholders in small sized rural municipalities in Rhodope Region of Bulgaria in successful launching and implementation of sustainable energy projects. The project focuses on creation of a pilot programme for financing investment by establishing Rhodoshop Programme Development Unit (PDU) - a structure to act as central procurement agency on behalf of local authorities to undertake energy retrofitting works in their buildings and street lighting systems. Rhodoshop PDU represents innovative financing model of One-Stop-Shop replicated in Rhodope/Bulgarian context, focused on building investment project pipelines that will combine/bundle suitable projects in the subscribed municipalities (currently six with the possibility to include others in the course of work) in order to gain critical mass and get better financing terms. After accomplishing the pipe-lines respective public tenders will be launched in compliance with Green Public Procurement principles in order to make the best choice of environmentally friendly, energy efficient and cost effective products and services. Within its 48 months pilot phase Rhodoshop PDU will mobilize 7.067 MEUR investments for energy efficiency improvements in 32 public buildings and 0.660 MEUR investments for refurbishment in street lighting networks in 31 settlements of Rhodope Region. The energy savings resulting from the action are assessed to 11.276 GWh/year.

Keywords: financing energy efficiency facilitation local authorities municipalities bulgaria
Demand for Democracy (DemandDemoc)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Germany,Hong Kong
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2022-12-31
Duration (months): 70.0
Total project cost (EUR): 1494647.0
EU funding (EUR): 939647.0
Participants: 2
Project status: SIGNED

Historically, people around the world have demanded democratic institutions. Such democratic movements propel political change and also determine economic outcomes. In this project, we ask, how do political preferences, beliefs, and second-order beliefs shape the strategic decision to participate in a movement demanding democracy? Existing scholarship is unsatisfactory because it is conducted ex post: preferences, beliefs, and behavior have converged to a new equilibrium. In contrast, we examine a democratic movement in real time, studying the ongoing democracy movement in Hong Kong. Our study is composed of four parts. In Part 1, we collect panel survey data from Hong Kong university students, a particularly politically active subpopulation. We collect data on preferences, behavior, beliefs, and second-order beliefs using incentivized and indirect elicitation to encourage truthful reporting. We analyze the associations among these variables to shed light on the drivers of participation in the democracy movement. In Part 2, we exploit experimental variation in the provision of information to study political coordination. Among participants in the panel survey, we provide information regarding the preferences and beliefs of other students. We examine whether exposure to information regarding peers causes students to update their beliefs and change their behavior. In Part 3, we extend the analysis in Part 1 to a nationally representative sample of Hong Kong citizens. To do so, we have added a module regarding political preferences, beliefs, and behavior (including incentivized questions and questions providing cover for responses to politically sensitive topics) to the HKPSSD panel survey. In Part 4, we study preferences for redistribution – plausibly a central driver for demands for political rights – among Hong Kong citizens and mainland Chinese. We examine how these preferences differ across populations, as well as their link to support for democracy.

Keywords: economic models of democratization,preferences for redistribution,political participation
Predicting the Impact of Monoclonal Antibodies & Vaccines on Antimicrobial Resistance (PrIMAVeRa)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Germany,Italy,Spain,Spain,Germany,Austria,Switzerland,Belgium,Lithuania,Russian Federation,France,France,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: Modelling the impact of monoclonal antibodies and vaccines on the reduction of antimicrobial resistance (H2020-JTI-IMI2-2020-23-two-stage, 2020)
Start date: 2021-11-01
End date: 2026-10-31
Duration (months): 60.0
Total project cost (EUR): 9250000.0
EU funding (EUR): 6500000.0
Participants: 20
Project status: SIGNED

Antibiotic resistance (AMR), a major threat to human health, is increasing in all bacteria through antibiotic-induced selection, cross-species transfer of genetic mobile elements harbouring resistance genes, global transport and environmental waste. With an almost empty antibiotic pipeline, monoclonal antibodies (mAbs) and vaccines are increasingly recognized as important tools against AMR. Yet, available resources cannot finance all potential interventions, and choices need to be made according to costs of mAbs and vaccines, impact on the burden of AMR and prevention of its economic consequences. The PrIMAVeRa consortium will develop a web-based platform that combines advanced mathematical models with a comprehensive epidemiological repository. Systematic reviews will generate data to inform the model structure and parametrisation and select the most appropriate models for determining the AMR burden by pathogen, infection and target population. Deterministic continuous time models (ordinary differential equations [ODE]) and stochastic discrete time individual-based models with multiple modules will cover all relevant aspects of AMR, while Bayesian approaches will be used for cost-effectiveness analysis. The models will be calibrated in 8 EU countries based on the data coming from health information systems. The PrIMAVeRa consortium comprises a prominent collection of European research groups with expertise in AMR, vaccines, mAbs, mathematical and economical modelling. The proposal builds on established research collaborations and existing research infrastructures from EU- and IMI-funded research projects, such as EPI-Net (COMBACTE-MAGNET) and CLIN-Net and LAB-Net (COMBACTE-NET). The major deliverable will be an open access web-based user interface that will allow the wider scientific community to freely access and apply the models. This platform will also help healthcare authorities to make data-driven decisions on which vaccines and mAbs should be prioritised.

Keywords: antibiotic resistance,mathematical modelling,vaccines,monoclonal antibodies
Robust Internal Thermal Insulation of Historic Buildings (RIBuild)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Switzerland,Belgium,Sweden,Latvia,Denmark,Denmark,Denmark
Call: Energy strategies and solutions for deep renovation of historic buildings (H2020-EE-2014-1-PPP, 2014)
Start date: 2015-01-01
End date: 2020-06-30
Duration (months): 66.0
Total project cost (EUR): 5331375.0
EU funding (EUR): 4962375.0
Participants: 10
Project status: CLOSED

RIBuild will strengthen the knowledge on how and under what conditions internal thermal insulation is to be implemented in historic buildings, without compromising their architectural and cultural values, with an acceptable safety level against deterioration and collapse of heavy external wall structures. The general objective of RIBuild is to develop effective, comprehensive decision guidelines to optimise the design and implementation of internal thermal insulation in historic buildings across the EU. RIBuild focuses on heavy external walls made of stone, brick and timber framing, as most historic buildings are made of these materials. The general objective is achieved through three main activities • To obtain a thorough knowledge level to characterise the eligibility of the building for a deep internal thermal insulation renovation. This knowledge is obtained through screening of historic buildings, investigation of material properties and threshold values for failure • To determine the conditions under which different internal insulation measures are reliable and affordable measures based on probabilistic modelling of the hygrothermal performance, the environmental impact and the cost/benefit • To develop a set of comprehensive decision guidelines and a web-based assessment tool, which are demonstrated in a number of buildings. RIBuild addresses the most difficult retrofitting measure of historic buildings: internal thermal insulation. The adaption of knowledge developed by RIBuild contributes to sustainable historic buildings with improved energy efficiency implying an easier conversion of energy supply from inefficient fossil fuels to efficient renewable energy sources. RIBuild also assesses the hygrothermal performance of the building construction, thus no collateral damage occurs; in case of failure an easy roll back of the measures is possible. The guidelines and the web-tool developed in RIBuild strongly support the deep and holistic retrofitting approach which historic buildings face in the coming years.

Keywords: internal thermal insulation,decision guidelines,probabilistic,building physics,life cycle impact assessment,durability
Biomaterials with incorporated MSC-secreted PARAcrine molecules for bone reGENeration (PARAGEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-03-20
End date: 2020-03-19
Duration (months): 36.0
Total project cost (EUR): 246668.4
EU funding (EUR): 246668.4
Participants: 2
Project status: CLOSED

Regeneration of bone defects remains a critical challenge in orthopaedics. Mesenchymal stromal cells (MSC) with biomaterials show huge promise for bone regeneration. However, MSC die shortly after implantation and act as mediators, by secretion of paracrine factors (PF), rather than effectors of bone formation. Importantly, it seems that delivery of cells themselves may not be required for therapeutic benefit. When MSC are cultured in vitro they release PF into their conditioned media (MSC-CM) including cytokines and extracellular vesicles. The goal of this project is to prepare novel biomaterials which are loaded with MSC-CM for in situ bone tissue engineering. PF secreted into MSC-CM during normoxia, hypoxia, and cell death will be measured. Biomaterials (biphasic calcium phosphate ceramics) will be functionalized with MSC-CM by using the polyelectrolyte multi-layering (PEM) method. The biocompatibility, release kinetics, and potential of MSC-CM loaded biomaterials for bone regeneration will be tested in vitro on cells involved in bone formation (MSC, monocytes, osteoclasts, macrophages, and endothelial cells) and in vivo by implanting the biomaterials in subcutis sites and segmented femoral defects in nude mice. Importantly, the delivery of MSC-CM can overcome the donor-dependent variability in bone formation associated with MSC cell therapy and permits a more straightforward transfer of this therapy to clinical treatment. Since MSC-CM is devoid of cells and doesn’t carry patient rejection risk, autologous MSC are not required. Therefore, selected MSC that successfully induce bone formation can be used to collect potent MSC-CM which can be loaded onto biomaterials for therapeutic use in countless patients. An ‘off-the-shelf’ product that could harness the benefits of MSC therapy but circumvent the costly and time consuming multi-step procedures involved with MSC implantation would be of immense interest to the bone regeneration field.

Keywords: biomaterials,secretome,cytokines,stem cells,tissue engineering,cell therapy,paracrine,exosommes
PLAY.CARE – revolution in early detection and therapy of autism spectrum disorders (ASD). (PLAY.CARE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Poland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-05-01
End date: 2019-10-31
Duration (months): 30.0
Total project cost (EUR): 2267500.0
EU funding (EUR): 1587250.0
Participants: 1
Project status: CLOSED

Autism is a serious developmental disability. Children with autism, also known as autism spectrum disorder (ASD), have social, communication and language problems. Prevalence estimates are alarming, with 1 in very 68 children being diagnosed with ASD in Europe. There is no cure for ASD. However, for many children, ASD symptoms improve with treatment and age. Early diagnosis and therapy intervention can help children with autism to significantly improve their language and behavioural skills, and raise their intelligence quotients dramatically. However, current ASD diagnosis methods fail to deliver. Most cases of child developmental disorders are detected much too late. Recognizing the striking gap in the ASD diagnostics landscape, we have developed and preliminarily validated, in cooperation with leading ASD experts, a disruptive technology for early detection and targeted therapy of ASD, based on the latest research on movement patterns as early markers of autism. PLAY.CARE has the potential to become a new ‘gold standard’ method for early autism detection and will lead to more timely detection of autism. Our aim is to scale the technology into clinical use worldwide, providing a reliable, easy-to-use, affordable and widely accessible diagnostic and therapy monitoring tool. The missing element to realize this vision is highest standard clinical evidence that will hold against all scientific scrutiny. Our objective is to obtain this evidence through the clinical validation pilot, subject of this proposal, and execute the necessary optimization and scalability of PLAY.CARE in light of market introduction.

Keywords: behavioural psychology,autism spectrum,behavioural patterns,artificial intelligence,big data,tablet based medical device,toddlers,preschoolers development,mhealth,mobile health,digital healt
commercialisation TridimensiOnal Nanoporous ALumIna Templates (TONALITy)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-07-01
End date: 2016-12-31
Duration (months): 18.0
Total project cost (EUR): 149953.0
EU funding (EUR): 149953.0
Participants: 1
Project status: CLOSED

One of the results obtained under the project nano-TEC (ERC-StG-240497) is an alumina template with three-dimensional nanopore architecture. This novel structure and its fabrication procedure have been the subject of a patent that has been recently filed. This structure has the novelty of being composed not only by vertically aligned pores, but also by tailor-controlled horizontal pores interconnecting them with their closest neighbour creating a three-dimensional net of nanopores. This template can also be used for the fabrication of highly ordered three-dimensional network of nanowires. Controlled and uniform assembly of nanowires with high scalability is still one of the major bottleneck challenges in fields such as energy harvesting, sensing, and device integration for electronics or catalysis. Moreover, since the spacing between horizontal interconnected nanopores is tuneable the colour of the alumina film can be controlled showing rainbow-like luminous colours that change with the angle of view, like in a Morpho butterfly wing. The work already undertaken under the nano-TEC project requires further investment in order to explore larger area, mass-production of these templates, for a further understanding of target markets and their limitations (regarding cost, aluminium purity, sizes, etc.). Finally, the objective will be to place some of the ERC-StG Nano-TEC results at market level.

Keywords: alumina,tridimensional network,colour
Antidepressants during pregnancy: underlying mechanisms associated with neurodevelopmental outcome (depreg)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

Depressive symptoms frequently occur during pregnancy and may have a tremendous impact on the developing child. Unfortunately, pharmacological antidepressant treatments during pregnancy can negatively impact behavioral development and health of the offspring. In humans it is difficult to discern between the effects of the drug and the effects of the depression itself, therefore it is unclear whether children exposed to antidepressants in utero are at increased risk, and if so, what the underlying molecular mechanisms are that may point to potential solutions. My overall aim is to identify molecular mechanisms and behavioral alterations in the offspring due to antenatal depression, antidepressant treatment during pregnancy, and their combination. To achieve this goal I will use an advanced rat model for depression to allow an experimental approach. I will identify the effects of antenatal depression, antidepressant treatment during pregnancy, and their combination on: (1) behavior of the offspring, (2) gene expression patterns with micro-array in the fetal brain, and (3) epigenetic profile of genes from the micro-array in adult brain and blood plasma. So far, Genome Wide Association Studies have not yielded new targets for the treatment of depressed (pregnant) patients. The outcome of this study will not only advance our knowledge on genes underlying the alterations found in brain and blood of the offspring due to antenatal depression, antidepressant treatment and their combination, but will also reveal early biomarkers as the epigenetic profile for the altered genes are studied. Ultimately, the results of this project will be beneficial for human health as it will open up new avenues for biomedical research and therapeutic applications.

Keywords: antenatal depression,antidepressants,pregnancy,behavior,gene expression,epigenetics,ssri
Magnetic Doping of 3D Dirac Semimetals (MagDirac)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-07
End date: 2021-01-06
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

A new field in condensed matter physics has emerged, dealing with new quantum states of matter originating from non-trivial topologies of the electronic band structure. Topological insulators were the first class of such materials. Dirac and Weyl semimetals are becoming the focus of the next major waive of research on topological matter. In these materials, the bulk valence band and conduction band touch at discrete points and disperse linearly (3D analogues of graphene). This project aims to answer a key fundamental question in this field: can time-reversal symmetry (TRS) breaking induce a Weyl state in a Dirac semimetal? The originality of our project resides on the idea of switching between Dirac and Weyl states using magnetism (TRS breaking), as the ON-OFF switch, instead of inferring the role of TRS by investigating Dirac and Weyl states in different compounds. We will synthesize epitaxial thin films of Cd3As2, the model 3D TDS, and induce a ferromagnetic state via magnetic doping. Subsequently we will perform a thorough investigation of the band structure (Dirac/Weyl cones, surface states and Fermi arcs), aiming to understand the coupling between magnetic and topological states, in particular, the switching between Dirac and Weyl states by breaking and restoring of TRS. In addition to its fundamental interest, this work has the potential to open a new research field dedicated to electrical switching between topological states, to be exploited in Dirac/Weyl-based electronic devices.

Keywords: dirac,weyl,topological,doping,ferromagnetism,band structure,arpes,thin films,cd3as2