Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
On/Off-Switchable Smart Nanobioreactors (SSNANO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-10-16
End date: 2013-10-15
Duration (months): 24.0
Total project cost (EUR): 210092.8
EU funding (EUR): 210092.8
Participants: 1
Project status: CLOSED

Nanobioreactor, a fascinating technology, is a latest combination of nanobiotechnology with advanced functional materials, are becoming promising tools for sensitive and selective novel biosensors. The aim of this research is to develop, synthesize and apply a new generation of stimuli-responsive switch-like nanobioreactors which own the self-switching textural ability to allow the specific recognition of target bioanalytes. The implementation of the project could generate important contributions to the development of stimuli-responsive advanced nano-materials for the various applications, such biocatalysts and nanobiosensors. To achieve the goals, a fundamental route to development of stimuli-responsive advanced materials is showed below: first, cationic polystyrene (PS) particles formed via emulsifier-free polymerization will be used as templates to prepare core-shell hybrid PS/SiO2 via the ammonia-catalyzed hydrolysis and condensation of (3-Mercaptopropyl) trimethoxysilane, Tetraethylorthosilicate and methacryloxypropyltrimethoxysilane. In the second step, cationic PS templates will be removed in toluene solution to form hollow silica particles. Subsequently, Au3+ will be assembled into inner pore of hollow silica through Au-S interaction and then reduced into nanoclusters by sodium borohydride. Finally, N-isopropylacylamide and 2-acrylamide-2-methylpropane sulfonic acid will be alternately grafted onto the surface of hollow silica particles, in the presence of N,N’-methylenebisacrylamide, to form an interpenetrating polymer network. The resulting nanoreactors would be expected to demonstrate on/off switchable behavior upon the contact with external stimuli such as temperature.

Keywords: biosensors,nanoreactors,au nanoparticles
Doped semiconductor contacts for low resistance contacts to carbon nanotubes (CNTCONTACT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2010-IIF, 2010)
Start date: 2011-06-01
End date: 2013-09-30
Duration (months): 24.0
Total project cost (EUR): 179101.6
EU funding (EUR): 179101.6
Participants: 1
Project status: CLOSED

Carbon nanotubes (CNTs) are attracting an immense research effort due to their remarkable electronic properties. The ability to integrate CNTs into applications such as sensors and low power transistors will allow the technology to fully benefit from these structures. The advantages CNTs offer include high sensitivity, very low power requirements, and the ability to use nanometer scale components. Key issues remain before the full potential of CNTs can be exploited: Low resistivity contacts must become available, CNTs must interface with high-k dielectrics, and we must understand their transport properties thoroughly. This project will address all three of these challenges. Further challenges related to growth and processing control are addressed by numerous researchers in the field. The primary goal of this project is to establish effective contacts to semiconducting CNTs. Interfacing CNTs with doped semiconductors such as Al:ZnO is proposed. An important side goal of the project is to develop a self consistent physical model to explain charge transport in CNTs, and to account for defects, transport barriers, and nonidealities at the CNT/contact interface. Such a model is also useful in calculating detailed band diagrams of the structures under study, which will help advanced device design. The doped semiconductor, Al:ZnO, will be deposited on top of CNTs using atomic layer deposition. This method offers a high level of conformal coating, and it is expected to yield low defect density conducting films. Detailed structural and electrical characerization using CNT field effect transistors as prototype devices will be carried out, providing data on the effects of pre- and post-deposition processing. Transport characteristics will be extracted from the characterization, and will be used in future iterations of the contacts. Low contact resistance and a thorough understanding of the transport properties are the expected outcomes of the project.

Keywords: solid state physics,electrical engineering,microengineering,physics of semiconductors,carbon nanotubes,contact materials,zinc oxide,doped semiconductors
Designing catalysis: Nitrogen-carbon ylids as methylene donors (DESIGNING CATALYSIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-04-01
End date: 2013-03-31
Duration (months): 24.0
Total project cost (EUR): 178101.6
EU funding (EUR): 178101.6
Participants: 1
Project status: CLOSED

Catalyst optimization is currently predominantly done by screening a large number of catalysts, rarely catalysts are designed by either chemical intuition or molecular modelling. In this proposal we will try to develop -by design- a new catalytic protocol using environmental benign reagents for the synthesis of cyclopropanes. The inspiration for this work stems from an interesting historical anomaly. In early work of Nobel prize laureate Georg Wittig cyclopropanation by the reaction of N-C-ylids as methylene donors with olefins was reported. Later these results were retracted. Possibly, traces of transition metals in one of the reagents were responsible for these inconsistent results. This observation prompts us to start an investigation of the interaction of N-C-ylids with transition metals. In this proposal we will combine (in)organic synthesis, mass spectrometry and molecular modelling to study the interaction of N-C-ylids with transition metals. Thorough understanding of these reactive intermediates will lead to novel synthetic (ideally catalytic) routes to cyclopropanes and the use of these intermediates in related synthetic transformations. Thus testing, validating and further developing our tools for design of catalysis and providing a environmentally benign industrial route to cyclopropanes.

Keywords: physical organic chemistry,designing catalysis,novel synthetic methodology,green chemistry,molecular modelling,mass spectrometry,n-c ylides/carbenes,methylene donor,cyclopropane
Facility location optimization under disruption and in an uncertain environment (FLOUE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2012-01-16
End date: 2013-01-15
Duration (months): 12.0
Total project cost (EUR): 69714.0
EU funding (EUR): 69714.0
Participants: 1
Project status: CLOSED

Facility location optimization is an optimization problem in operations research, particularly in network design decisions in the supply chain. In it most standard form (the Uncapacited Facility Location Problem), the problem can be stated as follows. Given some facilities, with known capacities (possibly infinite), some candidate sites, and customer demands, the problem consists in locating facilities on sites and assigning customers in such a way to satisfy all demands, without exceeding capacities, and at minimal fixed and variable costs. It is assumed that the decision problem occurs in some deterministic and reliable conditions. The customer demands and different costs are predictable, and facilities are so reliable that customers always get the service. Over the life of a logistic network, some services, transportation links, demands and costs, may experience disruptions or fluctuations. Thus, a network design that looks very good taking into account deterministic evaluation may be quite poor if the situation were to change. Our first purpose is to propose a “new” mathematical model for optimal location subject to disruptions on services. We first analyze the case of unlimited capacities and move to the limited capacities case. As a corollary, we examine the problem of optimally sizing safety capacity to satisfy additional demands. Finally, the failure aspects will be considered jointly with uncertainty on demands and costs. The general aim is to propose, for each problem, models, solution methods and algorithms that may be used by managers in designing logistic network taking into account uncertainties both on facilities availability, and on demands and costs. The theoretical and algorithmic elements that will be developed may be the backgrounds of a network design decision-aid software for network design with uncertainties. A prototype of such type of application will be developed to demonstrate the quality of our approach and to test various algorithms.

Keywords: facility location,optimization,operations research,mathematical programming,network design,supply chain,logistics network,algorithms,decision-aid software,demands,fized and variable costs
Nanofluidic Methods for Mapping Epigenetic and Genomic Variation (DNAMAP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2011-09-01
End date: 2014-08-31
Duration (months): 36.0
Total project cost (EUR): 243467.6
EU funding (EUR): 243467.6
Participants: 1
Project status: CLOSED

The objective of this project is to investigate nanofluidic single-molecule approaches to DNA mapping using a new denaturation mapping concept developed by W. Reisner. We propose to make advances in extending these approaches to true genome scale applications. We will furthermore demonstrate that epigenomic as well as genomic variations can be mapped with these approaches. Eventually, we seek to develop a device for mapping DNA that was extracted from single-cells on-chip. At the first stage of the project, the fellow will work with Prof. Reisner (McGill Univ.), who is a leader in nanofluidics for DNA analysis, and who will enable basic advances towards genome-scale and epigenetic mapping applications. Here, the fellow will study DNA mapping techniques and will learn how to design and fabricate nanofluidic devices for that purpose. Nanofabrication encompasses highly specialised tools and techniques which the fellow requires throughout the project. At the second stage, the fellow will be hosted by Prof. A. Kristensen (Techn. Univ. of Denmark) who is an expert in nanoimprinting and microfluidics. He will enable advances towards implementing inexpensive fabrication processes with integrated microfluidics for single-cell lysis and DNA purification. The fellow will therefore learn fabrication of polymer-based devices which can be mass-produced inexpensively by injection molding and nanoimprinting. Furthermore, the fellow will learn how to operate the fabricated on-chip devices with integrated single-cell lysis and DNA purification, and subsequent DNA mapping. The broad range of competencies the fellow will acquire throughout the project will help him establish an independent career in micro/nanofluidics. The proposed advances will contribute to technologies that can (1) speed-up large-scale genome assembly (2) analyse epigenomes/genomes from large ensembles of cells and (3) do so in an inexpensive format that can be widely distributed to potential biomedical end-users.

Keywords: molecular biophysics,nanobiotechnology,nanodevices,genetic mapping
barcoding approach for dendritic cells differentiation (BARDIF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-04-01
End date: 2013-03-31
Duration (months): 24.0
Total project cost (EUR): 176185.6
EU funding (EUR): 176185.6
Participants: 1
Project status: CLOSED

Dendritic cells, essential mediators of immunity and tolerance, are not a homogeneous cell type, but display a multitude of different functions and phenotypes. While the heterogeneity in phenotype and function of dendritic cells has been well described, our understanding of the in vivo origin of different dendritic cells subsets is still limited. Identification of the cellular intermediates on their way to dendritic cell differentiation will form an essential step to understand the dynamic regulation of the number, localization, and functionality of these cells and should contribute to the development of vaccination and immunotherapy strategy that rely on dendritic cells. The objectives of this project are to elucidate the genealogy of dendritic cells in vivo. To this purpose, I plan to use two complementary approaches. First, I will measure the fate of individual dendritic cells progenitors by the new experimental technology of barcoding that allows the tracing of a large number of individual cells in vivo. As the data obtained from barcoding experiments require mathematical modeling for proper interpretation, I will then develop a modeling approach to analyze the data. The results obtained in this project should yield a map of dendritic cells development in vivo under both steady state conditions and during infection. This cross-disciplinary approach to analyze dendritic cell commitment that I propose here should lead to a description of the genealogy of dendritic cell subsets, while at the same time providing a conceptual framework to analyze lineage differentiation issues for other cell types.

Keywords: dendritic cells,differentiation,barcoding,single cell approach,cell commitment. cell fate
Music, Terror and Manipulation under the Greek Junta (MUSTERMAN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-06-15
End date: 2014-06-20
Duration (months): 24.0
Total project cost (EUR): 156042.4
EU funding (EUR): 156042.4
Participants: 1
Project status: CLOSED

MUSTERMAN critically studies music’s role in manipulation and terror under the Greek military Junta (1967–1974). The cultural politics and musical culture of the Junta belong to a larger history of social control under repressive Cold War regimes. So far, musicological attention on the Greek case has focused exclusively on the music of resistance to the dictatorship; the music of the regime itself remains unstudied. MUSTERMAN aims to close this gap by investigating three aspects of the Junta’s musical culture: music as a medium of manipulation and propaganda; the gender aspects of the masculinized Greek national identity propagated by the regime; and the use of music as a weapon of torture. The analysis of these aspects will combine historical and empirical research with an appropriate critical and theoretical framework. It will reconstruct and document the Junta’s musical culture through archival and textual research, and interviews with torture survivors and torturers. An interdisciplinary framework for interpreting and assessing empirical findings will be developed from concepts and tools of critical musicology, psychoanalytical theory and trauma studies, and Critical Theory. MUSTERMAN aims to deliver a monograph to a major international academic publisher. This monograph will synthesize the research into an empirically rich and theoretically grounded critical account of the abuse of music under the Junta, moving beyond traditional musicology’s tendency to treat music as an invariably emancipatory and enlightening art-form. Intermediate project aims include the development of an online database archiving the reconstructed musical culture of the Junta and two articles for peer-reviewed journals. Plans for networking and knowledge transfer include research presentations, a conference, and a proposal for a training network. Results will also contribute to current international debates on human rights, international law and the ban on torture supported by the EU.

Keywords: humanities,musicology,greek junta,music,terror,manipulation,national identity,torture,witnessing,testimony,critical theory,psychoanalysis,trauma studies,memory
New silicon-derived environmentally-benign Lewis-acid catalysts for asymmetric synthesis (SILICAT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2010-IEF, 2010)
Start date: 2011-04-01
End date: 2012-09-30
Duration (months): 18.0
Total project cost (EUR): 140061.0
EU funding (EUR): 140061.0
Participants: 1
Project status: CLOSED

Lewis acids-promoted reactions of organic compounds have been extensively studied in recent years. Many region-, diastereo-and enantioselective reactions catalyzed by a wide variety of Lewis acids have been reported. Still they often have major drawbacks when applied to large scale synthesis: (1) use of toxic metal-derived catalysts, (2) low turn-over, (3) formation of large amounts of salts, (4) low chemoselectivity when applied to polyfunctional reactants, (5) extensive use of control elements ( activating or protecting groups), (6) use of significant amounts of solvents. A few years ago a new class of silicon-derived superacids ( trialkylsilyl triflimides) has been discovered by the group of Ghosez. These environmentally-friendly catalysts have received much attention in recent years. Our project is (1) to prepare a new class of tuneable silicon-derived “green” catalysts, (2) to test the catalytic activity of these new Lewis acids in representative reactions ( Diels-Alder, aldol, benzylation, allylation, Friedel-Crafts alkylation), (3) to prepare chiral catalysts (4) to test these catalyst in enantioselective syntheses. The candidate has a background in synthesis of bioactive compounds. He is now completing his training at the European Institute of Chemistry and Biology(IECB) in Pessac in the group of Prof. L. Ghosez. The training programme has been designed to ensure that the candidate’s ambition to acquire a broad formation in synthetic chemistry and pursue a career in that field will be fulfilled. Presently he works on a project supported by industry and is being trained in total synthesis of natural products analogs using original approaches which will required the development of new environmentally friendly catalysts. Training will be provided by the host group Ghosez at IECB. Additionally the candidate will benefit from the multidisciplinary character of the Institute where organic chemists, physical chemists and biologists interact everyday.

Keywords: chemistry,combinatorial chemistry,organic chemistry,asymmetric catalysis,organocatalysis,?green? catalysts,new synthesis
Molecular basis of beneficial plant-endophyte interaction - sustainable agriculture from within (ENDOPHYTES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-2010-IOF, 2010)
Start date: 2011-08-01
End date: 2013-07-31
Duration (months): 24.0
Total project cost (EUR): 174047.6
EU funding (EUR): 174047.6
Participants: 1
Project status: CLOSED

In todays world, there is a growing need for biomass for food, feed and fuel. The search for a suite of strategies for sustainable production of biomass is of great scientific, technological and societal interest, and there is a pressing need to identify novel targets that can be manipulated for designing new strategies to enable sustainable crop production at higher intensities with limited water supply and to reduce our dependency on synthetic pesticides. Microbial endosymbionts, endophytes, represent alternative sources of biocontrol agents as they can enhance growth and tolerance to a variety of biotic and abiotic stresses. The objectives of the proposed research project are to uncover the molecular mechanisms of beneficial interaction between the endophytes and the host plant. Specifically, to dissect the mechanism of their interaction by characterizing the mechanisms of initial colonization of the root surfaces, early infection, adaptation inside the hosts, and impacts on host innate immunity and growth. The outcome will generate valuable new knowledge to identify the key functions in plant growth promotion and plant protection. These findings will be useful to develop strategies to increase plant establishment and biomass production, for improved sustainable agriculture, bioenergy feedstock production on marginal lands, or fight desertification of arid areas.The project is novel and ambitious with the state-of-the-art knowledge and methodologies in microbial biofilm, plant cell wall biology and innate immunity in world leading research institution in microbial biofilm research in USA and in integrated plant research in Denmark.

Keywords: natural sciences,endophytes,microbial biofilm,plant molecular biology and physiology