Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
On-demand production of entirely customised minimally invasive medical devices (OPENMIND)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Spain,Ireland,Italy,Germany,France,Czechia
Call: Manufacturing of custom made parts for personalised products (H2020-FoF-2015, 2015)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 4528568.75
EU funding (EUR): 4528568.75
Participants: 9
Project status: CLOSED

With the development of powerful real-time imaging modalities, the sector of minimally invasive surgery has grown massively in the last decades. The easy and reliable navigation of the medical devices used in these environments is one of the key aspects for the success of such an operation. Currently, only a limited spectrum of devices for these interventions is available defined by the medical device manufacturers. The physician has to choose from this available (predefined) product range. However, for a successful outcome of advanced minimally invasive interventions it is essential to fulfil the needs of the physician who has to solve a complex task: navigating and operating in the human vascular system without having a direct view. Each physician has her or his own imagination of the ideal device for a specific intervention regarding handling and visibility. To maximise the ease of use of the medical devices and, thus, to optimise the outcome of the intervention a customised product would be the perfect solution. Therefore, the OPENMIND will develop the first highly flexible process chain for the on-demand production of entirely customised minimally invasive medical devices. This process chain will close the gap between efficiently produced standard products and individually designed products, enabling even the production of small batch sizes down to single batches in a continuous, automated and fully monitored process chain. The OPENMIND project will be using a guide wire as demonstrator device for showing the successful outcome of the project. The process chain will be completed by a comprehensive monitoring and data mining toolset. All relevant process data will be monitored and analysed in order to reduce development times by predicting appropriate parameter sets for the manufacturing of new customised products. Furthermore, the data will be used to realise automated optimisation of the running process.

Keywords: personalised minimally invasive surgery devices,fibre reinforced plastics,micro pullwinding process,data mining,similarity algorithms,statistical process control for varying lot sizes,process
Collective wisdom driving public health policies (CrowdHEALTH)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Germany,Spain,Taiwan, Province of China,Cyprus,Switzerland,Greece,Slovenia,Sweden,Greece,Romania,Greece,United Kingdom,United Kingdom,United Kingdom
Call: Big Data supporting Public Health policies (H2020-SC1-2016-CNECT, 2016)
Start date: 2017-03-01
End date: 2020-02-29
Duration (months): 36.0
Total project cost (EUR): 5333300.0
EU funding (EUR): 4999550.0
Participants: 24
Project status: CLOSED

Today’s rich digital information environment is characterized by the multitude of data sources providing information that has not yet reached its full potential in eHealth. CrowdHEALTH will introduce a new paradigm of Holistic Health Records (HHRs) that include all health determinants. HHRs will be transformed into Social HHRs communities capturing the clinical, social and human context of the population segmentation and as a result the collective knowledge for different factors depending on the communities formulation criteria (e.g. demographics, diseases, lifestyle choices, nutrition, etc). CrowdHEALTH will deliver a secure integrated ICT platform that seamlessly integrates big data technologies across the complete data path, providing of Data as a Service (DaaS) to the health ecosystem stakeholders. CrowdHEALTH will develop policy modeling techniques to facilitate the inclusion of Key Performance Indicators (KPIs) in policies and the correlation of these KPIs both with all health determinants captured in HHRs and with information from other domains towards a “health in all policies” approach. Creation and co-creation (cross-domain) of policies will be feasible through a rich toolkit, which will be provided on top of the DaaS, incorporating mechanisms for causal and risk analysis, as well as for compilation of predictions. Through the toolkit, multi-modal targeted policies addressing various time scales (long- / short- term), locations (area, regional, national, international), populations, and evolving risks will be realized. CrowdHEALTH will facilitate policies evaluation (on complete policy and per-KPI levels) and optimization through adaptive and incremental visualizations of simulations and outcomes of evidence based analysis of prevention strategies. CrowdHEALTH will collect data and will be validated through 5 pilots addressing different environments (care centers, social networks, public environments, living labs, diseases monitoring).

Keywords: multiple information sources,big data management,spatiotemporal development of diseases,emerging risks,patient pathway,policy making,information extraction and cleaning,data integration
Smart Implants from Safe CERAmics (SISCERA)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Germany,Sweden,France,France,France
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 2760688.75
EU funding (EUR): 2200044.0
Participants: 6
Project status: CLOSED

Great advances were made by SISCERA partners in the development of the world’s first ceramics showing transformation induced plasticity and perfect predictability. These specifically designed materials were the main research results of the LongLife FP7 project and will be brought to market via SISCERA. The LONGLIFE material is based on a novel, highly biocompatible ceramic coupled with a specific surface modification, procuring enhanced osseointegration to implants. Its reliability and mechanical performances have been validated in accordance to the relevant standards. The core objective of SISCERA (Smart Innovations from Safe CERAmics) is to prepare market penetration by the end of 2019 of the first commercial application of this revolutionary ceramic. This new type of material can serve industries such as biomedical (implants, bone saws, prostheses), automotive & fuel cell. DMC will commercialise the material for several applications: (i) ceramic bars (for Anthogyr and biomedical customers), (ii) centering pins for car body welding (for existing automotive industry customers), and (iii) positioning devices for handling robots (for existing industrial customers). SWEREA will apply its surface modification process to facilitate production of solid-oxide fuel cells. The partners have carefully analysed the different markets and have determined that the most strategic initial biomedical application is the dental implant. This market is expected to grow annually by 6-8% during the next years, to 5.4 Billion € by 2020. Ceramics are entering the market as implant materials, but their use is still limited by inadequate toughness and osseointegration. The SISCERA consortium has the ideal material and expertise to provide the first dental implant fully meeting patient needs. The current FTI project will allow partners to obtain clinical and biocompatibility validation of the implant while also penetrating the market with promising applications in other industries.

Keywords: high toughness ceramics,predictable mechanical properties,implants,biocompatibility,enhanced osseointegration,clinical validation
Novel concept of cost-effective hybrid concrete/steel Auxiliary Shielding Module for enhancing the Radiological, Thermal and Structural behaviour of Spent Nuclear Fuel Dry Storage metallic casks (ASM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-10-01
End date: 2019-01-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

After a few years, the fuel used in a nuclear reactor can no longer produce energy efficiently, and becomes spent nuclear fuel (SNF). A key concern for nuclear power-producing countries is the management of this fuel. The closure of NPPs, together with the lack of final repositories and limited countries with reprocessing facilities forces NPP operators to store the SNF in the Independent Spent Fuel Storage Installations (ISFSIs) of the plant with two currently available solutions: - Dry Storage in Dual-Purpose (storage and transportation) metallic casks: the reduced dose mitigation implies the construction of a cover to the ISFSI to create an additional shield. - Dry Storage in concrete casks: not valid for transportation and weight restrictions. In response to this market need, INGECID is now developing (currently at TRL6) the Auxiliary Shielding Module (ASM). ASM consists of 4 rings which are located surrounding the metallic container. The structural part of each of the rings is made by stainless steel and consists in an inferior flange, and two ferrules (interior and exterior). The inside is filled by concrete to assure the radiological function. ASM offers a completely new solution for open-air SNF dry storage with a unique conjunction of features that are no found in any other commercially available solution: 1. Cost-competitive: ASM means a fraction (20%) of the cost of a covered ISFSI.. 2. Light weight:. Optimal solution for ISFSIs with weight restrictions. 3. Dose reduction in one magnitude order for each container. 4. Additional protection shield against overturns, accidents, impacts or seism. 5. Ease of use: Installation with the same crane used for the manipulation of the metallic casks. 6. No need of construction of additional facilities within the NPP, (no EIA needed). 7. Provide an additional dose mitigation of the metallic casks during its lifetime (storage and transport). 8. Flexibility: ASM thickness customized attending Client requirements.

Keywords: spent nuclear fuel,waste management,nuclear power plants,storage systems,dose,radiological emissions
Measurement and Analysis of Generator bearing Loads and Efficiency with Validation (MAGLEV)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,United Kingdom
Call: Demonstration and test of low-loss, high reliability, high speed, bearing-relief generators (H2020-CS2-CFP09-2018-02, 2018)
Start date: 2019-10-01
End date: 2022-11-30
Duration (months): 38.0
Total project cost (EUR): 1009345.0
EU funding (EUR): 1009345.0
Participants: 2
Project status: CLOSED

The project (MAGLEV) objective is to make a significant contribution to the new class of bearing relief generators. This contribution will be developed by building a demonstrator machine. Technical methods will be developed to reduce misalignments and vibrations of the generator, enabling operation at higher power density and efficiency compared to the existing solutions. MAGLEV will develop cutting edge IP, which could change the world of electrical machines completely if successful, and should be able to secure and enhance EU industries’ competiveness. MAGLEV includes challenging tasks such as measuring shaft instantaneous position and bearing loadings accurately in dynamic operating conditions at high speed, developing a control technology to emulate the loads on the generator with a bearing relief system, the commissioning of the demonstrator machine, obtaining test data, and validating the simulation results with test data. Close and efficient communication with the Topic Leader is one of the key success factors in MAGLEV.

Keywords: generator efficiency and reliability improvement,power density improvement through higher speeds and electrical frequency,permanent magnet solutions with active rectifiers,improve control technology
TransEpiSeed: The role of mRNA methylation in control of seed germination (TransEpiSeed)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Seed germination is a unique phase of the plant life cycle. Its correct coordination is crucial for seedling establishment, and germination is, therefore, key for crop survival and yield. The improvement of seed germination will be highly important for modernized precision agriculture. Seeds accumulate a substantial amount of translationally inert mRNA during maturation. These mRNAs have a strikingly long half-life allowing seeds of certain plant species survive up to thousands of years. Upon water-uptake, these mRNAs are translationally activated in support of seed germination. The function of mRNAs stored in dry seeds has been a mystery for decades. My recent work demonstrated that these stored mRNAs are associated with ribosomes and that they get translated during early seed germination. Therefore, an understanding of the regulatory mechanisms that govern the storage of these mRNAs in dry seeds, and their eventual translation upon germination will reveal tremendous insight into seed germination. A multitude of mechanisms might affect mRNA translation. Common to them is that they must involve sequence-specific recognition of a signal within the transcript, such as an mRNA modification. N6-methyladenosine (m6A), the most widespread internal mRNA modification, has been shown to have important role on mRNA stability or translation efficiency involving recruitment of specialized m6A-binding proteins, in plants referred to as EVOLUTIONARILY CONSERVED C-TERMINUS (ECT) proteins. TransEpiSeed aims to study the relevance of m6A for translational control during seed germination by investigation of m6A dynamics and the function of ECT proteins. Combining my knowledge on the translational regulation of seed germination with expertise on m6A of the host lab provides a strong base to increase the insight into the regulation of seed germination. The results will provide opportunities for high-quality seed production and strengthen my skills required as advanced seed biologist.

Keywords: epitracriptomics,ribosome,translation,seed,germination
Neural mechanisms of multisensory perceptual binding (ACoolTouch)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-09-01
End date: 2023-02-28
Duration (months): 78.0
Total project cost (EUR): 1999877.0
EU funding (EUR): 1999877.0
Participants: 1
Project status: CLOSED

Sensory perception involves the discrimination and binding of multiple modalities of sensory input. This is especially evident in the somatosensory system where different modalities of sensory input, including thermal and mechanosensory, are combined to generate a unified percept. The neural mechanisms of multisensory binding are unknown, in part because sensory perception is typically studied within a single modality in a single brain region. I propose a multi-level approach to investigate thermo-tactile processing in the mouse forepaw system from the primary sensory afferent neurons to thalamo-cortical circuits and behaviour. The mouse forepaw system is the ideal system to investigate multisensory binding as the sensory afferent neurons are well investigated, cell type-specific lines are available, in vivo optogenetic manipulation is possible both in sensory afferent neurons and central circuits and we have developed high-resolution somatosensory perception behaviours. We have previously shown that mouse primary somatosensory forepaw cortical neurons respond to both tactile and thermal stimuli and are required for non-noxious cooling perception. With multimodal neurons how, then, is it possible to both discriminate and bind thermal and tactile stimuli? I propose 3 objectives to address this question. We will first, perform functional mapping of the thermal and tactile pathways to cortex; second, investigate the neural mechanisms of thermo-tactile discrimination in behaving mice; and third, compare neural processing during two thermo-tactile binding tasks, the first using passively applied stimuli, and the second, active manipulation of thermal objects. At each stage we will perform cell type-specific neural recordings and causal optogenetic manipulations in awake and behaving mice. Our multi-level approach will provide a comprehensive investigation into how the brain performs multisensory perceptual binding: a fundamental yet unsolved problem in neuroscience.

Keywords: somatosensory,cortex,mouse,behaviour
Cerebellar circuit mechanisms of coordinated locomotion in mice (LOCOMOUSE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Portugal
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-04-30
Duration (months): 60.0
Total project cost (EUR): 1496750.0
EU funding (EUR): 1496750.0
Participants: 1
Project status: CLOSED

A remarkable aspect of motor control is our seemingly effortless ability to generate coordinated movements. How is activity within neural circuits orchestrated to allow us to engage in complex activities like gymnastics, riding a bike, or walking down the street while drinking a cup of coffee? The cerebellum is critical for coordinated movement, and the well-described, stereotyped circuitry of the cerebellum has made it an attractive system for neural circuits research. Much is known about how activity and plasticity in its identified cell types contribute to simple forms of motor learning. In contrast, while gait ataxia, or uncoordinated walking, is a hallmark of cerebellar damage, the circuit mechanisms underlying cerebellar contributions to coordinated locomotion are not well understood. One limitation has been the difficulty in extracting quantitative measures of coordination from the complex, whole body action of locomotion. We have developed a custom-built system (LocoMouse) to analyze mouse locomotor coordination. It tracks continuous paw, snout, and tail trajectories in 3D with unprecedented spatiotemporal resolution and it has allowed us to identify specific, quantitative locomotor elements that depend on intact cerebellar function. Here we will combine this quantitative behavioral approach with electrophysiology and optogenetics to investigate circuit mechanisms of locomotor coordination. We will 1) Optogenetically silence the output of cerebellar subregions to understand their distinct contributions to locomotion. 2) Record from identified neurons and correlate their activity with specific locomotor parameters. 3) Optogenetically stimulate defined cell types to investigate circuit mechanisms of coordinated locomotion. These experiments will establish causal relationships between neural circuit activity and coordinated motor control, a problem with important implications for both health and disease.

Keywords: cerebellum,locomotion,coordination,optogenetics,electrophysiology
Design of selective lignin depolymerization routes by the means of biphasic solothermolysis. (SolvoLig2Chem)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

The SolvoLig2Chem (solvothermolysis of lignin to chemicals) project deals with development of methods for production of green and sustainable aromatic monomers from extracted lignins (e.g. organosolv and formaldehyde treated lignin) by the means of solvothermolysis, a particularly promising thermochemical conversion technique combining relatively mild reaction conditions (170-250 °C, 1-2 MPa) with high yields of various monomers (e.g. catechols, guaiacols, cresols, alkylphenols, methoxybenzenes). These compounds are high-value products in addition to being the only naturally generated replacement for aromatic monomers used extensively in the chemical industry. The overall aim of this project is to design and test selective solvothermal biphasic depolymerization (SBD) routes by the combination of experimental work, development of innovative analytical techniques, and theoretical studies of the reaction mechanisms. The objectives will be achieved by performing cutting-edge research at Paul Scherrer Institute in Switzerland, one of the leading research institutes within natural sciences in Europe. By combining a vivid research environment, extensive collaboration, excellent laboratory facilities, state-of-the-art analytical instrumentation, and large scale facilities (e.g. synchrotron radiation at Swiss Light Source, SLS), both the scientific (designing selective depolymerization routes for lignin) as well as the personal (training and development of the researcher leading to a position of scientific maturity) goals of this action will be reached. The potential benefits of the studied conversion technique are nearly unlimited: replacing petroleum as the main source of polymers and materials, promoting sustainable and green development, and mitigating the human impact on the environment and the climate.

Keywords: technical lignins,biphasic systems,solvothermal conversion,value added products,aromatic monomers,biorefinery,reaction routes,selective depolymerization,mass spectrometry