Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
European Training Network on Bone Pain (BonePain)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Sweden,Netherlands,United Kingdom,United Kingdom,Denmark,United Kingdom,Denmark
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3558676.32
EU funding (EUR): 3558676.3200000003
Participants: 9
Project status: CLOSED

The aim is to create an innovative European PhD training network in bone pain. Millions in Europe and beyond suffer from bone pain, a debilitating complication of many musculoskeletal disorders such as arthritis and bone metastasis. However, being a truly multidisciplinary subject spanning neuroscience, bone biology, and even cancer research, it demands a multidisciplinary approach. Despite a huge negative impact on the quality of life of the patients and on society as a whole, no specific treatment is available. To address this societal challenge and the strong innovation potential, we want to form the first European platform to promote frontline research, innovation and education within bone pain. The network encompasses 5 academic and 2 industrial beneficiaries and 1 industrial partner all committed to creating an outstanding wide-ranging yet integrated training program for early stages researchers to elucidate the mechanisms of bone pain and develop new medicines. We will use in vivo models of arthritic pain, cancer-induced bone pain and fracture pain to investigate the pathophysiology and novel treatment strategies. In vivo electrophysiology will be used for studying the physiology and pharmacology of pain transmission and its modulation. Transgenic mouse models will be used to tease out the specific neuronal receptor subtypes involved. Sophisticated behaviour tests will evaluate response to novel treatments. We will create a biobank of human cancer-infiltrated bone to identify specific patterns of neuronal receptor expression and to validate therapeutic targets in humans. In an extensive training effort covering both specific research skills and transferable skills, the students will obtain an interdisciplinary, state-of-the-art and innovative training from the participants, several of which have experience from international networks. The students will benefit from secondments with industrial partners and with some of the foremost pain researchers in Europe

Keywords: bone pain,musculoskeletal pain,arthritic pain,cancer induce bone pain,fracture pain,animal models,behaviour tests,peripheral neural mechanisms,central neural mechanisms,drug testing
Translating quantum sensing into cost-effective molecular imaging (QUSMI)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Germany
Call: FET Innovation Launchpad (H2020-FETOPEN-4-2016-2017, 2016)
Start date: 2017-05-01
End date: 2018-10-31
Duration (months): 18.0
Total project cost (EUR): 96462.5
EU funding (EUR): 96462.3
Participants: 2
Project status: CLOSED

The ability to recognize molecular processes using novel imaging techniques is of fundamental importance for medicine, biology and biochemistry in the 21st century. Non-invasive molecular imaging has gained widespread use in patient management of cancer, life-science and medical research, as well as drug discovery and development. The capability of non-invasive metabolic profiling is expected to impact dramatically patient management for socioeconomically relevant diseases. Spatially-resolved observation of metabolites will be key for enabling more accurate staging of diseases by direct assessment of the underlying impact on the metabolism. Quantification of, for example, the perturbation of the myocardial, tumor, or neural substrate metabolism will most likely revolutionize staging and management of diseases in cardiology, neurology, oncology and other fields. Building on novel quantum technology using nitrogen-vacancy in diamonds we have developed in first in the DIAMANT FET project, and continued the FET proactive project DIADEMS - DIAmond Devices Enabled Metrology and Sensing, we are developing an MRI-based breakthrough technology for enabling previously unachievable, highly sensitive quantification of metabolic imaging, enabling earlier diagnostic and personalized therapies, thus substantially improving patient management. However, research and development are not sufficient for attracting private investors and commercialization of a disruptive technology. In QUSMI we will understand the customer needs, reach out to strategic partners, consolidate our IP portfolio and strategy, and develop our business plan. Thus placing us in a position to attract private investors and commercialize the research technology into a product.

Keywords: dynamic nuclear polarization,hyperpolarized mri,optical dnp
Semantic Transformations for Rail Transportation (ST4RT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Italy,Italy,Belgium,France,Czechia,Netherlands
Call: Interoperability Framework Converters (H2020-S2RJU-OC-2016-01-2, 2016)
Start date: 2016-11-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 8
Project status: CLOSED

The objective of the proposal is research in semantic, ontology based automation of transformations between heterogeneous data formats, and its application to a complex ‘after-sales’ process use case in an actual run-time demonstration scenario. The technology will leverage Shift2Rail Interoperability Framework (IF) components developed in the IT2Rail “lighthouse” project, extending it for use in related Shift2Rail projects under the “S2R-CFM-IP4-01-2015: Shopping, booking and ticketing of multimodal travel solutions” and “S2R-CFM-IP4-02-2015: Travel companion and tracking services” calls. The project will additionally provide a case scenario for exercising the Governance and management structure developed under the related “S2R-OC-IP4-01-2016: IF Governance, ensuring its market uptake and sustainability” call. The objectives will be achieved through a partnership of specialist participants including research institutions, a major European rail operator, industry associations representing the rail sector and public transportation authorities, and industrial providers of mission critical ICT solutions to the rail sector. Participants, which are also involved in the original consortium of designers for the IF in IT2Rail, will perform work organised in specific work packages focused on fundamental industrial research in semantic web technologies. These technologies will comprise ontology engineering and automated semantic transformations, in a dedicated work package, to provide the actual runtime demonstration scenario of the application of such technology to transformations of existing European TAP-TSI specification exchanges executed on an existing industrial platform for such exchanges. The project extends the capabilities of the IF as described in the Shift2Rail Multi Annual Action Plan contributing to the realisation of a distributed semantic “web of transport” integrating the TAP-TSI specification as one of its elements.

Keywords: interoperability framework,semantic data transformation,tap tsi,semantic heterogeneity,ontology
A technology marketplace for hospitality compliance services that integrates with public sector authorities and relieves the burden of regulation for businesses (SwiftC)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Ireland
Call: New business models for inclusive, innovative and reflective societies (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-09-01
End date: 2019-10-31
Duration (months): 26.0
Total project cost (EUR): 2212798.75
EU funding (EUR): 1548959.0
Participants: 1
Project status: CLOSED

The EU attaches the highest political priority to Better Regulation or ‘Smart Regulation’ which envisages a whole-of-government approach to the policy cycle extending from design to evaluation and revision. The annual cost of regulation to business is conservatively estimated to 3.5% of EU GDP. For the hospitality industry, the burden of regulation is proportionately greater owing to the high distribution of SME’s and increasing public safety and environmental control that drives a 4% increase in compliance costs year on year. Trade bodies frequently cite regulations as unfair and anti-competitive. SwiftComply has developed an innovative and exciting new approach to delivering and monitoring hospitality compliance. Our solution creates a marketplace between food service businesses and compliance service providers. SwiftComply provides oversight of all transactions to regulators, allowing a real-time understanding of compliance activity and enabling them to focus on areas of non-performance. This is an efficient, business friendly and cost effective approach to reducing the burden of regulation and has worldwide application for food safety, building control, fire and environmental regulations. SwiftComply has demonstrated the marketplace in the area of fat, oil and grease compliance in Dublin, Ireland and has commenced pilots in 3 US cities. This Project has the objective of scaling up, refining and demonstrating our solution to meet the strong customer demand identified during Phase 1 market analysis. SwiftComply has raised private sector seed funding of €1.3m and will use H2020 funding to maximise speed to market and competitive advantage in Europe. SwiftComply has worldwide application and the potential to reach an annualised turnover of €63m, deliver a 86% gross profit margin, create over 600 jobs and digitise 4.5m pieces of paper by 2023. Successful completion of this Project will lead directly to a Series A fundraising round and full market exploitation.

Keywords: marketplace,smart regulation,compliance
European Stratospheric Balloon Observatory Design Study (ESBO DS)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Germany,Sweden
Call: Design Studies (H2020-INFRADEV-2017-1, 2017)
Start date: 2018-03-01
End date: 2021-07-31
Duration (months): 41.0
Total project cost (EUR): 3267158.11
EU funding (EUR): 3009563.61
Participants: 5
Project status: CLOSED

Following the findings of the H2020-funded ORISON project, we propose the design and development of a new European astronomical research infrastructure for stratospheric balloon-based telescopes. Our approach is to provide a versatile community-accessible observatory capable of covering unserved scientific needs, including those of star- and planet formation studies and exoplanet research. These are particularly associated with requirements for high spatial and spectral resolution far-infrared (FIR) observations, high sensitivity UV observations, and highly accurate visible light photometry. To a certain extent, these needs could also be addressed by space missions. A balloon infrastructure, however, will offer a more cost-efficient and flexible approach, allowing instruments more adaptable to evolving needs (exchangeable and less risk-adverse), longer overall observation times (possibility to refill cooling fluids), and larger mirror sizes (less severe launcher restrictions). So far, stratospheric telescopes, with the exception of SOFIA, have mostly served a single purpose and did not fly more than a few times. The proposed infrastructure, in contrast, will provide regular flights, allowing it to operate as a true observatory. The infrastructure will be prepared in two parts within the project: 1) Conceptualization of the full distributed infrastructure with several flight platforms, including a suitable governance and operating structure for long-term operations and development. These will build upon a highly sensitive UV platform and lead to a next-generation FIR platform with unprecedented spatial resolution. A development roadmap will summarize the necessary development steps and funding needs. 2) Technical demonstration of the manageability and safe recovery of a versatile high-performance astronomical balloon mission via a prototype carrying a next-generation UV-detector and a visible light camera for photometric tests.

Keywords: astronomy,observatory,scientific instrumentation,scientific ballooning,far infrared astronomy,ultraviolet astronomy
Black holes in gauged Supergravity: Supersymmetric and Holographic properties (GaugedBH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

In attempting to extend Einstein’s theory of gravity, general relativity, to the quantum regime, scientists have encountered crucial technical and conceptual difficulties. On one side, the non-renormalizability of the graviton field coupled to the Standard Model of particle physics shows the inadequateness of quantum field theories to include gravity at arbitrary energies. On the other side, black holes, one of the most intriguing solutions of general relativity, have posed a puzzle shaking the axioms of the known theories: the information paradox about the dynamics of black hole formation and evaporation. Among the advances towards a consistent unification of general relativity and quantum field theory, String- and M-theory have offered one of the most consistent frameworks in which to address these difficulties. This proposal will focus on black hole solutions of gauged Supergravity, which describe the low energy limit of String/M- theory. The applicant has produced fundamental contributions to this subject that have driven the latest developments in the field. By exploiting the training at the host institution, this proposal aims at a deeper understanding of black holes in connection to String/M-theory and the holographic dual quantum field theories. The case of Anti de Sitter black holes will be the first objective, involving the construction of new solutions and their applications to holography studies. The dynamics of an in-falling observer in the black hole interior will be studied via holographic techniques. The second objective concerns flat space black holes obtained from “flat” gaugings, whose evolution is affected by charged particles. In both cases, multi-center black holes will be analyzed. Beyond the main goal of advancing the understanding of gravity and black holes, the impact of the results will be broad, from areas of applied holography in condensed matter systems to the mathematical fields of algebraic geometry and number theory.

Keywords: black holes in string theory and supergravity,cft correspondence,supergravity models
The environmental fate and effects of microplastics in freshwater ecosystems (FreshwaterMPs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

EU member states are currently working towards the realisation of environmental goals specified in the Water Framework Directive (WFD), which aims to protect both human and ecosystem health. Microplastic particles (MPs) are emerging pollutants of increasing concern and are formed primarily when plastic waste degrades in the environment. The impacts of MPs on freshwater biota are not known, however, they may present a potentially persistent and ecotoxicological pollution problem. Accordingly, the goal of this project is to assess the environmental risk of MPs in freshwater habitats. To achieve this, a detailed investigation of MP environmental persistence will be carried out. This will provide environmental fate summaries for different polymer classes and enable the modelling of their degradation processes. This will be combined with laboratory studies to assess relevant sub-lethal endpoints such as reproduction, fitness, inflammation, and oxidative stress. As MPs are known to accumulate co-occurring organic pollutants, the toxicity of virgin MPs will be compared to MPs conditioned with relevant freshwater pollutants. This work will build towards a sophisticated state-of-the-art mesocosm study that will evaluate both MP fate and impacts in model ecosystems. The establishment of a novel framework for the environmental risk assessment of MPs will inform our ability to achieve conservation objectives taking into account MPs as emerging pollutants. The merit of this is that protection goals may be better accommodated in policy and management through the generation of so far unavailable data on MP persistence and environmental toxicity. Taken together, the project will generate so far unavailable data sets to assess for the first time the environmental impacts of freshwater MPs. Thus, the outcomes will highly relevant for academia, politics, stakeholders and society.

Keywords: microplastics,freshwater,environmental fate,environmental risk assessment,ecotoxicology,chemical sorption,behavioural effects,morphological effects,reproductive effects
Increasing resource efficiency of aviation through implementation of ALM technology and bionic design in all stages of an aircraft life cycle (Bionic Aircraft)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Germany,Italy,Spain,Germany,Switzerland,France,United Kingdom
Call: Enhancing resource efficiency of aviation (H2020-MG-2015_TwoStages, 2015)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 7968812.0
EU funding (EUR): 6441062.0
Participants: 11
Project status: CLOSED

Additive Layer Manufacturing (ALM) processes can significantly contribute to the demanding task within the Strategic Research and Innovation Agenda (SRIA) to reduce the impact of aviation on the environment. The unique manufacturing process of ALM technologies promises great weight saving potential, due to the possibility to produce bionically optimized lightweight structures of high complexity in a resource efficient way with a material exploitation of >90%. Airbus envisions completely new types of aircrafts, inspired by biomimetic, which will only be manufacturable by a broad application of ALM. Unfortunately, the design process as well as manufacturing process itself is time consuming and expensive, limiting the applicability in the aerospace industry. To overcome these barriers and to be able to exploit the potential ALM offers to reduce emissions along the entire life-cycle of an aircraft, the following developments are planned: • automated ALM design process to significantly reduce time and costs for bionic lightweight design • energy efficient and highly productive ALM process with innovative beam shaping optics to lower costs of manufacturing and reduce emissions during manufacturing • new high strength ALM aluminium material to increase the lightweight potential of ALM structures • integrity system for complex ALM parts for integrity check and avoidance of deficient parts • innovative NDT and repair methods for highly complex ALM parts to increase service life • recycling method for ALM parts to avoid disposal • innovative after sales supply chain based on ALM to reduce emission for spare parts production and logistics With these developments, the project will raise the potential of ALM-technology and biomimetic design methodologies and will reduce the impact of aviation on the environment along the entire product-life-cycle of an airplane (Design & Product Development; Manufacturing; Operation; Maintenance, Repair, Overhaul; Recycling; Disposal)

Keywords: resource efficiency,biomimetics,additive layer manufacturing
Genetics of metabolically healthy obesity (MHO) and metabolically unhealthy normal weight (MUNW) in children, and the childhood predictors of adulthood MHO and MUNW (Child-MHO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2019-03-31
Duration (months): 12.0
Total project cost (EUR): 106097.4
EU funding (EUR): 106097.4
Participants: 1
Project status: CLOSED

Background: Recent large-scale genomic studies have provided evidence that a number of genetic variants implicate an inverse relationship between increased adiposity and an unfavorable cardiometabolic profile. So far, it is not known whether the loci showing “favorable adiposity”-like associations exert their influence already in childhood. Objectives: The aims of the project proposed are 1.The identification of gene variants associated with increased adiposity yet a favorable cardiometabolic profile in children and adolescents and 2. Identification of the childhood genetic and environmental predictors of adult metabolically healthy obesity (MHO) and metabolically unhealthy normal weight (MUNW). The approach: To study, whether such “favorable adiposity” genetic effects are found already in childhood, I will perform a meta-analysis of six child populations from Finland, Denmark and England including a total sample size of 10,038 children and adolescents aged 3-18 years. To examine associations of childhood genetic and environmental factors with MHO and MUNW in adulthood, I will utilize follow-up data from the Cardiovascular Risk in Young Finns study. The impact: Identification of MHO and MUNW related genetic variants in children and the childhood predictors of adult MHO and MUNW will help to assess the risk of type 2 diabetes and cardiovascular disease as well as to target interventions in the high-risk groups. The ability to improve advice and intervention measures would help alleviate the burden of obesity-related comorbidities on health care systems worldwide. Moreover, this project will allow me to learn highly valuable research skills in the area of genetics and meta-analyses related to cardiometabolic risk factors and support my professional and research advancement.

Keywords: obesity,overweigt,children,genetics,life style,early growth,insulin resistance,waist circumference