Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Statistical Inference from Multiscale Biological Data: theory, algorithms, applications (SIMBAD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France,Netherlands,Italy,Cuba,Argentina,United Kingdom
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 740600.0
EU funding (EUR): 740600.0
Participants: 8
Project status: SIGNED

The last two decades have witnessed giant experimental breakthroughs in different areas of the life sciences, from genomics to epidemiology. Thanks to modern high-throughput techniques, biological systems across multiple scales –from single molecules up to entire populations– can now be probed quantitatively at high spatial and temporal resolutions. Besides enhancing our basic knowledge of a system’s constituents, these data potentially encode a plethora of information about the functional constraints that govern its evolution and the physical constraints that limit its performance, as well as about levels of organization, dynamical constraints or design principles that would be hard to identify from low-throughput data. Extracting this information is also crucial for applications ranging from the design of proteins with a desired functionality to the reconstruction of contacts during an epidemics. Inverse statistical mechanics attempts to do it by inferring generative models (Boltzmann distributions) from data using methods from the physics of disordered and random systems. Specific characteristics of biological data however, like strong undersampling and heterogeneity, limit the effectiveness of these tools. SIMBAD aims at developing a class of statistical inference techniques capable of overcoming these issues. In SIMBAD, theoretical work will supply concepts and methods to address four pressing problems (learning protein sequence landscapes, inverse modeling metabolic networks, inferring contact networks from epidemiological data, and improving survival analysis models), which in turn will guide the theory towards integration with the existing standards of each field. This effort promises to open new pathways for basic research to impact economic, technological and societal issues; the high- profile cross-disciplinary expertise represented in SIMBAD ensures instead for measurable and achievable objectives, placing SIMBAD in an ideal position to achieve its goals
NGI Zero Core (NGI0 Core)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Countries involved: Netherlands,Spain,Germany,Ireland,Belgium,Czechia
Call: Internet architecture and decentralised technologies (RIA) (HORIZON-CL4-2022-HUMAN-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 11499375.0
EU funding (EUR): 11499375.0
Participants: 11
Project status: SIGNED

We fund a large amount of third parties to review and upgrade the open Internet architecture (hardware, software, protocols) to increase the performance of the network, adapt it to new application requirements, improve quality of service, make it more resilient to security threats, more energy efficient and respectful of the environment (e.g. reparability, recyclability), and increasingly supportive of open and decentralised technologies and services. With the size of the budget available and our methodology, NGI0 Core involves 150 000 to 300 000 person hours of directly funded human effort contributed to the public benefit and the good of the internet. A multiple of that will be generated indirectly within the ecosystem around open source and standards. NGI0 Foundations is important to set the course of the evolution of technology and strengthening the role of Europe within future developments. In all this we benefit from decades of experience, including significant experience gained within the various NGI efforts we have supported.
Master Framework and Pragmatic Clinical Trial for Relapse or Refractory Acute Myeloid Leukemia (IMPACT- AML)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Cyprus,Germany,Czechia,Belgium,Lithuania
Call: Pragmatic clinical trials to optimise treatments for patients with refractory cancers (HORIZON-MISS-2022-CANCER-01, 2022)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 5988402.5
EU funding (EUR): 5988402.5
Participants: 18
Project status: SIGNED

In IMPACT-AML, a multidisciplinar R/R AML represents a model of high-impact disease, in which no standard of care exists, and where we have an urgent need for new evidence on possible therapies; AML offers the setting in which methodological innovation will combine powerful instruments of clinical trials with personalized medicine through academic efforts. Hereby, we propose to create an inclusive master framework for relapsed or refractory acute myeloid leukemia (STREAM) to include patients with R/R AML across Europe proficiently acquire an unselected population for clinical trials and monitor outcomes including neglected cohorts. Thereafter we will conduct a prospective randomized pragmatic clinical trial (RPCT) that will compare the classical “high intensity” rescue chemotherapy with biology-driven, “low intensity” rescue to obtain “real world” data on the benefit of one of the two different strategies in term of survival also considering patients and caregivers preferences, patient-reported outcomes (PRO), accessibility, affordability, and social cost. RPCT will aim to evaluate the effectiveness of real-world clinical alternatives in routine care. In addition to retaining the high internal validity of traditional randomized trials, it will maximize external validity, i. e. generalizability of results to many settings. In this context, the inclusion of an RPCT in the master framework will allow a dynamic inclusion and the collection of the excluded population as an instrument to predict the real-life applicability of clinical trial results. We will offer Europe results from an ambitious project, that will go beyond the state of the art in R/R AML demonstrating the superiority of a strategy in a first-of-his-kind clinical trial, providing strong data that will be delivered to national health care providers, policymakers, and health authorities data on optimized and affordable treatment for R/R AML and promoting the implementation of the selected better option. This action is part of the Cancer Mission cluster of projects on ‘Diagnosis and treatment’.

Keywords: master framework,prospective randomized pragmatic clinical trial,relapsed or refractory acute myeloid leukemia
State Agents on Trial: Hierarchies of State Criminality in Israel and France (SATHSCIF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,France,Switzerland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 225987.6
EU funding (EUR): 225987.6
Participants: 4
Project status: SIGNED

Since WWII, global politics has developed a heightened sensitivity to state violence. Although this sensitivity contributed to a reduction in state violence, it also constructed an economy of state criminality that situates sex crimes as the worst atrocity while normalising other forms of violence. This logic is further exacerbated when state security agents (SSAs) stand trial for crimes committed during service. These trials require the public to come to terms with the cost of security and renegotiate the boundaries between legitimate and illegitimate state violence. Studying SSAs’ trials as sites of contention over the state’s legitimate use of violence, I will explore: (1) What hierarchies are at work in shaping conceptions and reactions to state criminality? (2) What do these hierarchies teach us about social and political tolerance of state violence? and (3) Which political, social, and moral factors are at work in transforming hierarchies of state criminality? Conducting qualitative research based on archival work, I will explore how legal-normative infrastructures facilitate hierarchies of state crime in Israel and France from WWII to the end of the 20th century. By studying SSAs’ trials in these sites, the project will develop a model to assess hierarchies of state criminality based on three categories of felonies: crimes against body and life and property and sex crimes. I hypothesise that a different hierarchy is at play when SSAs commit such felonies compared to ordinary citizens. When SSAs are the perpetrators, I expect to find that property and sex crimes are judged more harshly than crimes against life and body that can be justified as a security necessity. If so, it is essential to design policies that break down these hierarchies, treating state criminality holistically. This research will therefore produce recommendations for human rights organisations to promote new methodologies and theoretical approaches to state criminality.

Keywords: sexual violence,palestine israel,politics of care,critical criminology,critical security studies,comparative politics,legal and political anthropology
GoNaturePositive! (GoNaturePositive)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Ireland,Denmark,France,Spain,Italy,Belgium,Colombia,Portugal,Austria,United Kingdom,Slovakia,Germany,Sweden,Netherlands,Czechia
Call: Build up of knowledge on Nature Positive Economy and supporting its scale-up (HORIZON-CL6-2023-BIODIV-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 5029696.25
EU funding (EUR): 5029696.25
Participants: 22
Project status: SIGNED

The world’s economic systems do not currently recognise the value of nature to planetary and human health, and mainstream economic drivers negatively affect the natural world both directly and indirectly. The degradation of land and marine ecosystems undermines the well-being of billions of people, costing about 10% of the annual global gross product. However, the restoration of nature presents enormous economic opportunities. The idea of a Nature-Positive Economy (NPE) – an economy that fully considers environmental impacts and sustainability, and works to actively improve the state of nature – and the pathways towards realising it remain poorly understood. The ambition of GoNaturePositive! (GoNP) is to provide much-needed clarity and direction through a transdisciplinary consortium adopting a multi-stakeholder approach for systemic change, with nature-based solutions (NBS) and nature-based enterprises (NBEs) at its core. Five European and one Global Pilot (covering Agri-Food, Forestry, Blue Economy, Tourism & the Built Environment) will be co-created with industrial, political, NGO and societal stakeholders. In GoNP we will deliver a clear definition and conceptual framework for the NPE, a roadmap proposing policy and governance pathways towards a NPE, blueprints for ground-breaking solutions to stubborn roadblocks, and demonstrations of what a NPE could look like on the ground. GoNP will demonstrate how nature-positive practices can generate multiple benefits for people and planet while reducing business risk and attracting increasingly nature-sensitive investors. It will pay particular attention to the role and potential of NBEs, developing unique platforms and capacity building measures to help them scale for maximum nature-positive impact. Finally, we will cultivate Nature-Positive leadership, harnessing the commitment of an Impact Board of multiplier networks towards achieving a long-term shared vision of the Nature-Positive Economy.

Keywords: nature based enterprises nature positive nature positive economy
Enabling spatially-resolved mapping of electric activity in operational devices at atomic-resolution (ELECTRON)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 2082500.0
EU funding (EUR): 2082500.0
Participants: 1
Project status: SIGNED

Advanced materials are at the core of innovation in the 21st century for a wide range of industries, including semiconductors, consumer electronics, automotive, and aerospace. Demands for products with increased functionality, performance, and reduced power consumption are driving the need for new device structures and materials. Designing, characterizing, and testing of two-terminal devices such as MIM (metal-insulator-metal) capacitors for high performance DRAM capacitors or MSM (metal-semiconductor-metal) select elements for advanced non-volatile memory are key for improved materials stack design and integration. In ELECTRON, I will develop a technique that allows to directly image "brain-like" functions in operational e.g. RRAM devices. I aim to achieve operando electron beam-induced current imaging (EBIC) inside a scanning transmission electron microscope (STEM) by using amplifiers to measure electrical currents in a contacted working device exposed to a microscope ́s electron beam, and thus, for the first time map electrical activity of a real device, like neuroscientists use for example, fMRI to track blood flow within the brain: the parts that are being used will light up in the map. This technique will enable a unique and previously non-existent way to visualize electric activity in working devices while being sensitive to electric potential, electric field, work function, conductivity and temperature under simultaneous external stimuli (i.e. heating, biasing, gas). I propose this project based upon the internationally recognized expertise of my group in the development of situ/operando TEM, specifically, the ability to operate and electrically contact stack devices inside an electron microscope and my experience in MEMS-based chip platform design (Nature Communications, 4445(2018)). The goal is to push the spatial resolution of STEM-(SE)EBIC to reach atomic-resolution dimensions while probing industry relevant electronic devices under realistic conditions.

Keywords: structure property relations functional materials electronic devices metal insulator metal structures operando microscopy electron beam induced current imaging
automated in-line separatioN and dEtection of eXtracellular vesicles for liqUid biopsy applicationS (NEXUS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,United States,France,Germany
Call: EIC Transition Open 2021 (HORIZON-EIC-2021-TRANSITIONOPEN-01, 2021)
Start date: 2022-06-01
End date: 2025-05-31
Duration (months): 36.0
Total project cost (EUR): 2497750.0
EU funding (EUR): 2497750.0
Participants: 5
Project status: SIGNED

The NEXUS project will develop an easily customizable integrated platform to enable Extracellular Vesicles (EVs) separation, purification and multivariate characterization from complex biofluids. EVs enclose a heterogeneous group of cell-released membranous vesicles, abundantly present in body fluids from which they can be extracted in a non-invasive manner. Their surface markers and cargo (proteins, nucleic acids, glycans, lipids) represent an ideal source of diagnostic, prognostic and efficacy biomarkers, providing real-time information on tissue homeostasis alterations. However, their detection and molecular profiling is technically challenging due to their physical characteristics and huge heterogeneity. The previous FET project INDEX has validated at lab scale (TRL4) an integration of a selective sequential isolation and in situ enrichment of small EVs (sEVs) from plasma, with the multiparameter analysis regarding vesicle size, number and immunophenotype. NEXUS aims at proceeding towards industrialisation by delivering a manufacturable, full-fledged analytical instrument, characterised by an appealing ?sample in ? result out? design and featuring a real time in liquid measurement of scalable sample volumes. NEXUS breakthrough technology will be achieved through integration of: i) innovative chemistry for reversible sEVs immunocapture with unique Capture-Release-Re-capture features; ii) microfluidic extraction and pre-concentration of cancer sEVs; iii) DNA barcoded customizable chips for single sEV capture and analysis. Fully automated Interferometric Reflectance Imaging Sensor providing rapid, sensitive and multiplex profiling of cancer proteins, displayed on sEVs without the interference of soluble proteins and confounding particles (other sEVs and lipoproteins), will be validated in the relevant industrial and clinical environment and in the context of a Liquid Biopsy assay for Prostate Cancer Stratification, Prognosis and Monitoring and Prognosis (TRL6).

Keywords: extracellular vesicles,exosomes,liquid biopsy,diagnostics,microfluidics,immunocapturing,interferometry,system integration,biosensing platform,prostate cancer,personalized medicine
Nanoscale Integrated Magnetic Field Sensor (NANOSENSE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-01-01
End date: 2024-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Magnetic sensors are present everywhere in our daily lives. We often use them in cars, robotics, medical applications, for power sensing, electronic compass, etc. Among them, magnetoresistive sensors play an increasing role thanks to their relatively small size, good sensitivity and low cost. However, magnetoresistive sensors saturate above typically a few milli-Tesla which is too low for a number of applications. Besides, reducing the sensor footprint is important in terms of costs. In addition, smaller sensors have also a reduced power consumption which is very important for wearable applications and sensors used in Internet of Things. Therefore, it is commercially desirable to be able to develop a low cost, nano-size, magnetoresistive sensor in which the dynamic range could be extended and easily adjusted in the range 80mT-400mT commonly used in linear or angular encoders. Within an ERC project which just ended entitled “CMOS/Magnetoelectronic Integrated Circuits with Multifunctional Capabilities”, a novel concept of magnetic field sensor sensitive to out-of-plane field was proposed and patented. Initial experiments performed within this ERC project provided very promising results. The purpose of this ERC project is to make a full proof of concept of this sensor demonstrating its outstanding performance and subsequently move towards a start-up creation or licensing of the technology to an existing sensors manufacturer. Within NANOSENSE, we aim to achieve gains over existing sensors by 10x in terms of footprint reduction, 50x in power consumption, 10x in signal to noise ratio while increasing the sensing range up to ~800mT. This will make these sensors suitable for integration in sensors network for IoT, sensors for wearable applications, automotive, detection of leakage current in electronic circuits, detection of microcracks in metals, navigation of surgical tools (e.g.endoscopes).
SISSVid: Secure and Intelligent Storage System for Large-scale Visual Data Analytics (SISSVid)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-04
End date: 2025-11-03
Duration (months): 26.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 2
Project status: SIGNED

The ever increasing demand for video surveillance for security and video analytics has exponentially raised the magnitude of video data, resulting in substantial challenges in the storage and retrieval of needed information. Moreover, because of escalating security threats to individuals' identities, General Data Protection Regulation (GDPR) focuses on ensuring lawful and transparent processing of human data by adopting Data Protection-by-Design (Article 25, 47) and data minimisation (Article 5). The project "SISSVid" proposes a GDPR enabled solution considering both video storage and retrieval perspectives to ensure the safety of human recordings. SISSVid includes the reversible anonymization of personal data for secure storage and retrieval by following the GDPR’s principle of data minimisation. The project implementation will significantly improve the storage and post-event text-to-video retrieval of existing systems. The project will focus on digital rights and human rights in the recorded closed circuit television (CCTV) data, with applications in sustainable cities and communities thus aligned with UN sustainable development goals (SDGs); SDG 9, SDG 11, and SGD 16. This project is interdisciplinary and also multidisciplinary that includes artificial intelligence, image/video processing, security and privacy, and law (GDPR). Dr. Mamoona Asghar (former MSCA Career-Fit research fellow) is an appropriate supervisor, as she possesses immense experience in the implementation of technological solutions for the privacy of visual data. Besides, the University of Galway places a strong focus on providing a supportive environment for researchers. This project will advance the career of the fellow by providing multidisciplinary training and industry collaborations in Ireland. Additionally, this project promotes the main objective of MSCA i.e. establishing a long-term collaboration network between the researcher and European institutions, bringing excellence together.

Keywords: cctv,privacy,secure storage systems,intelligent video retrieval,video surveillance,gdpr