Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
First single platform for efficient and security aware management of CMS based websites (PerfectDashboard 2.0)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: SME instrument
Countries involved: Poland
Call: Engaging SMEs in security research and development (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-10-01
End date: 2016-12-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

This proposal addresses the very up-to-date challenge in the domain of cyber security which affects today thousands of websites administrators worldwide – ability to efficiently introduce updates to popular website engines and extensions to popular CMS platforms such as WordPress and Joomla!. In our proposal we show how our solution can increase safety in the Internet by helping web page managers be far more effective in their daily routines. These are primarily focused on updating web pages commonly developed with popular CMS platforms in order to remove identified vulnerabilities and thus prevent or mitigate hackers’ activities. With our application already proven by individual web admins an administrator may not only introduce necessary changes in the code mitigating the risk of a security breach much faster than ever before, but he or she can ensure the final effect does not impact on the web page layout and its contents. These are the features highly needed by corporate users what was verified through discussions with corporate users in media, technology and entertainment sectors. With our solution they can ensure their web services are provided in an undisturbed and secure way avoiding potential loss of reputation due to web page break and potential change of its contents. In our proposal we present the current stage of Perfect Dashboard 2.0 development, demonstrate results of the conducted trails and cornerstones of our business plan which we would like to enhance during the Phase 1 project targeting corporate users. Finally, we anticipate our plans for further evolution of our solution and its subsequent commercialization along with presentation of our potential. Perfect Dashboard 2.0 is strategically important for our company and Phase 1 project may accelerate this process beyond our current capabilities helping us resolve vital market related questions and boost our business in short time.

Keywords: cms management,hacking,prevention,webpage updating,exploits,bots,security vulnerabilities,backup
Great ape organoids to reconstruct uniquely human development (ANTHROPOID)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-06-01
End date: 2024-05-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1038782.71
Participants: 2
Project status: SIGNED

Humans diverged from our closest living relatives, chimpanzees and other great apes, 6-10 million years ago. Since this divergence, our ancestors acquired genetic changes that enhanced cognition, altered metabolism, and endowed our species with an adaptive capacity to colonize the entire planet and reshape the biosphere. Through genome comparisons between modern humans, Neandertals, chimpanzees and other apes we have identified genetic changes that likely contribute to innovations in human metabolic and cognitive physiology. However, it has been difficult to assess the functional effects of these genetic changes due to the lack of cell culture systems that recapitulate great ape organ complexity. Human and chimpanzee pluripotent stem cells (PSCs) can self-organize into three-dimensional (3D) tissues that recapitulate the morphology, function, and genetic programs controlling organ development. Our vision is to use organoids to study the changes that set modern humans apart from our closest evolutionary relatives as well as all other organisms on the planet. In ANTHROPOID we will generate a great ape developmental cell atlas using cortex, liver, and small intestine organoids. We will use single-cell transcriptomics and chromatin accessibility to identify cell type-specific features of transcriptome divergence at cellular resolution. We will dissect enhancer evolution using single-cell genomic screens and ancestralize human cells to resurrect pre-human cellular phenotypes. ANTHROPOID utilizes quantitative and state-of-the-art methods to explore exciting high-risk questions at multiple branches of the modern human lineage. This project is a ground breaking starting point to replay evolution and tackle the ancient question of what makes us uniquely human?

Keywords: single cell genomics,stem cell biology,3d organoids,human evolution
COllective action Models for Energy Transition and Social Innovation (COMETS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Robust decision making and public engagement
Action type: Research and Innovation actions
Countries involved: Estonia,Italy,Spain,Italy,Belgium,Norway,Poland,Belgium,Netherlands,Denmark
Call: Social Sciences and Humanities (SSH) aspects of the Clean-Energy Transition (H2020-LC-SC3-2018-NZE-CC, 2018)
Start date: 2019-05-01
End date: 2022-04-30
Duration (months): 36.0
Total project cost (EUR): 3000000.0
EU funding (EUR): 3000000.0
Participants: 12
Project status: CLOSED

There are large knowledge gaps around the governance of the low carbon energy system transition in a smooth and participative way, ensuring that citizens are at the centre of the required fundamental transformation and enabling the full efflorescence of their creative potential. Social innovation is a prime way to tap into that potential while Collective Action Initiatives (CAIs), a social innovation in itself, are a prime way to mobilize people and to ensure the acceptance for and participation in the necessary transition process. However, both social innovation and CAIs lack proper scientific and field-tested understanding of their development and factors for success. As of today, the role of citizen-driven CAIs (e.g. energy communities, cooperatives, purchasing groups) and their contribution to the energy transition has neither been quantified at an aggregate level, nor has their contribution potential been estimated or understood in sufficient depth. The COMETS project aims to fill these knowledge gaps by quantifying the European-wide aggregate contribution of CAIs to the energy transition at national and European levels by investigating their evolution and scaling up at an in-depth level in six selected countries. The main expected impacts of the project are two-fold. Firstly, COMETS will advance the scientific knowledge on the motives, desires, objectives and barriers of such collective action initiatives and their historical and future role in the energy transition. Building on the information gathered and tested for its robustness, we will then co-develop and test supportive tools together with CAI members, decision makers and the scientific community. Lastly, these stakeholders will then be able to exploit the main outputs of COMETS, namely a Supporting Platform for CAIs, the enhanced knowledge base, scenarios and roadmaps for spreading CAI models, even after the project is concluded.

Keywords: collective action,energy transition,societal change,decentralized energy systems,citizen engagement,mobilize people,scenarios and roadmaps,presumption,comparative case studies,consortium benchmarking
An AR cloud and digital twins solution for industry and construction 4.0 (ARtwin)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Greece,France,France,Czechia
Call: Interactive Technologies (H2020-ICT-2018-3, 2018)
Start date: 2019-10-01
End date: 2022-12-31
Duration (months): 39.0
Total project cost (EUR): 3825148.75
EU funding (EUR): 3825148.75
Participants: 8
Project status: CLOSED

Industry and construction 4.0 have high expectations of AR technologies in terms of productivity gains and quality improvement. Numerous proofs of concept demonstrate significant returns on investment but difficulties occur when it comes to large-scale deployment in operational dynamic environments exposed to variable lighting conditions. To overcome these limitations IT leaders (Google/Apple/Microsoft) investigate ARCloud technology in building a 3D map of the environment in the cloud which can be updated and shared by any AR device, allowing collaborative AR experiences and a more robust and accurate 3D registration. Unfortunately, the early-stage ARCloud implementations do not fully meet industry and construction 4.0 requirements and European players may face a lock-in situation if no sovereign solution is proposed to them. ARtwin project aims to provide European Industry and Construction 4.0 with a ARCloud platform that meets their needs. This platform deployed on a private distant or/and edge cloud ensures the privacy of information and offers three key services: (i) an accurate and robust 3D registration for any AR device in large-scale and dynamic environments, allowing to present relevant information to workers at the right time and place, (ii) reduction of the difference between the physical and digital world by continuously maintaining the Digital Twin/BIM model based on vision sensors available in the factory or on construction sites, (iii) display of complex 3D augmentations on any AR device by remotely rendering them in the cloud with ultra-low-latency. The ARtwin platform and services will be validated in operational environments through two use cases in Industry 4.0 and a use case in Construction 4.0. The results of the format of the 3D map stored in the cloud will be submitted to standardization bodies to prevent lock-in situation with few vendors and encourage an ecosystem with a diverse range of solutions providers (small players, academics, etc.)

Keywords: arcloud,industry4 0,construction4 0,3d map
Swift COronavirus therapeutics REsponse (SCORE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Belgium,Belgium,Switzerland,France,France,Netherlands,Netherlands
Call: Advancing knowledge for the clinical and public health response to the 2019-nCoV epidemic (H2020-SC1-PHE-CORONAVIRUS-2020, 2020)
Start date: 2020-04-01
End date: 2022-09-30
Duration (months): 30.0
Total project cost (EUR): 2627551.25
EU funding (EUR): 2576062.5
Participants: 10
Project status: CLOSED

Coronavirus 2019-nCoV has become a worldwide public health emergency, and the lack of vaccines and drugs to immediately address this outbreak is painfully clear. Even if the epidemic can be stopped, the virus may return in the same or a modified form. More than vaccines and therapeutic antibodies, antiviral drugs can target highly conserved viral functions and have the broad-spectrum activity that is critical to combat current and future outbreaks. Since the 2003 SARS outbreak, as leading academic coronavirus researchers, we have collaborated to understand and inhibit coronavirus replication. We defined viral key functions, developed tools for inhibitor screening, and identified/engineered drug candidates. Until 2015, our collaborative efforts were supported by the FP7 SILVER project, but they have been continued until this very day. As European coronavirus experts, we now propose the SCORE project, supported by a leading pharmaceutical company. Virologists, biochemists, structural biologists, and medicinal chemists will collaborate in a state-of-the-art drug discovery/design program that targets 2019-nCoV. Our vast SARS-CoV-derived expertise and unique toolbox will be a major asset to achieve immediate impact. We will target the virus using 5 independent approaches: (i) using of (combinations of) FDA-approved drugs, (ii) targeting viral RNA synthesis, (iii) inhibiting coronavirus proteases, (iv) blocking virus entry, (v) discovery and development of new antivirals. This program will be supplemented with 2019-nCoV toolbox and animal model development. We aim to deliver proof-of-concept for selected compounds within 6-9 months, after which they will be offered for further use/development. This will contribute to short-term solutions for the on-going crisis and also pave the way for mid/long-term success in developing inhibitors that will be active against (evolving) 2019-nCoV strains, other SARS-like coronaviruses, and potentially (beta)coronaviruses at large.

Keywords: antiviral drug development,coronavirus enzymes,compound library screening,nucleosides,protease inhibitors,entry inhibitors,ncov toolbox,adme tox profile,ncov rodent models
ExoData: a commercially supported space telescope (ExoData)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2015-11-01
End date: 2017-04-30
Duration (months): 18.0
Total project cost (EUR): 139454.0
EU funding (EUR): 139454.0
Participants: 1
Project status: CLOSED

ExoData will use results from the very successfull ExoMol Advanced Award which created comprehensive spectroscopic line lists to help understand and model the atmospheres of exoplanets. ExoData will help build and fund a satellite aimed at characterising exoplanet atmospheres using a cheap, agile, low earth orbit satellite mission with a launch date this decade. This mission will be part funded by the sale of telescope data to interested international clients. This is a new business model for astonomical satellites. ExoData will (a) fund business development in partnership with a small company created to sell telescope and other data from this mission and (b) use the results of the ExoMol project to model results from this mission and to create software and models that have potential re-sale value. The deliverable will be funded space mission and a novel business model.

Keywords: space
Large-scale piloting and market maturation of a novel process for sustainable European lobster aqua- and mariculture (SELAM)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Norway
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-2-2015, 2015)
Start date: 2015-10-01
End date: 2018-09-30
Duration (months): 36.0
Total project cost (EUR): 1673283.75
EU funding (EUR): 1171298.63
Participants: 1
Project status: CLOSED

The objective of SELAM is to commercialise and bring to market our exclusive and high-quality EU lobsters based on our disruptive and fully automated production process for lobster aqua and mariculture. The fully automated SELAM process is combining land-based aquaculture of hatched eggs through the larval (1-3) and juvenile (4-5) stages before released into sea-ranching ocean mariculture, where growth happens without human interference and at no cost. Combined with our novel business model for shellfish sea ranching this will allow us to bring a new product to the market – sustainable and high-quality farmed EU lobster with significant added value for the customer compared to existing wild-caught alternatives. The SELAM concept was developed during our Phase I-type Feasibility Study - the FP7 NEPHROPS project, GA286903 - where the outcome was a novel production process with optimal production parameters (feed, light, temperature & water quality) at TRL7. Now we seek to op develop our Commercialisation Plan and final Business Innovation Plan (BIP). We have assembled a highly competent team holding all required resources, skills, facilities and networks to advance SELAM into a successful commercial product. To successfully introduce SELAM to the market, we have created 5 sequential and quantifiable Commercialisation Objectives focusing on overcoming remaining barriers hampering successful commercialisation: 1. Technology maturation, elevating our SELAM process from TRL7 to TRL8 (WP1) 2. Large scale piloting bringing SELAM to TRL9 (WP2) 3. Supply chain development, up- and downstream (WP3) 4. Product exploitation strategy development, market research and post-project funding (WP4) 5. Innovation management and BIP development, IP management and stakeholder engagement (WP5) SELAM will significantly boost our growth - quantified as accumulated revenues exceeding €151m for the 10-years post project with accumulated gross profit €94.9m and employment growth of 52 FTEs.

Keywords: european lobster,homarus gammarus,sea ranching,mariculture,automation
Translational Research Network in Prostate Cancer (TransPot)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Finland,Finland,Finland,Switzerland,Greece,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-01-01
End date: 2021-04-30
Duration (months): 52.0
Total project cost (EUR): 2629315.8
EU funding (EUR): 2629315.8
Participants: 18
Project status: CLOSED

The Translational Research Network for Prostate Cancer (TransPot) program adopts an innovative, multidisciplinary approach, providing highly sought-after, effective solutions for incurable prostate cancer (PC). The TransPot scientific objective is to obtain an unmatched depth of molecular, mechanistic and informatics systems-level disease understanding in order to improve the prognosis and treatment of lethal PC, aimed to (i) provide important insights into molecular mechanisms driving treatment resistant PC including castrate-resistant PC (CRPC), (ii) identify novel therapeutic targets, (iii) develop and validate predictive models for disease progression, prognosis and responsiveness to current and novel (co-)treatment options, and (iv) provide superior, clinically relevant tools and biomarker signatures for personalising and optimising CRPC therapy. Our research program is built on network-wide, state-of-the-art cancer biology-based mechanistic research integrated with a systems medicine approach: 1. Cancer biology-based mechanistic research incorporating a comprehensive range of model systems incorporating unique, pre-clinical and clinical resources and distinct phenotypic high content screen platforms. 2. A systems medicine approach with mathematical modelling to develop novel predictive/prognostic tools. 3. Centres of excellence in surgery, oncology and clinical trials, comprising clinical infrastructure and essential resources whereby candidate therapeutic targets and predictive/prognostic tools can be comprehensively evaluated, including accessing bio-repository resources. We will train young scientists to apply multiple ‘omics’ technologies and approaches in model systems and systems biology to answer important clinically-relevant questions. Advances achieved will facilitate personalized targeted-medicine in treating lethal PC, and will impact beyond the scientific community by improving the well-being of advanced PC patients.

Keywords: translational research,prostate cancer,model systems,systems biology,signalling,androgen,receptor,target for therapy
Bioelectroreduction of nitrogen to ammonia: the incorporation of nitrogenase within enzymatic biological fuel cells for simultaneous production of electrical energy and ammonia. (Bioelectroammonia)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Ireland,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2020-03-30
Duration (months): 36.0
Total project cost (EUR): 248063.4
EU funding (EUR): 248063.4
Participants: 2
Project status: CLOSED

Enzymatic biological fuel cells (EBFCs) utilise enzymes as biological catalysts to produce electrical energy from chemical energy, usually being fuelled by simple molecules such as glucose or ethanol, in the presence of O2. This technology provides an alternative to the use of expensive metal catalysts (such as platinum) and offers the ability for electrical energy to be produced under much milder conditions, such as near-neutral pH and room temperature. The cathodes of EBFCs usually employ O2 as the oxidant and final electron acceptor; this proposal seeks to utilise N2 in its place. Not only does the use of N2 as the oxidant circumvent issues relating to dissolved O2 concentrations and solubility (limited to less than 1 mM), but it also presents the possibility to produce industrially important NH3 (using a novel technology) whilst simultaneously producing electrical energy.

Keywords: enzymatic biological fuel cell nitrogen fixation by nitrogenase ammonia production