Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hibernation timing to reveal mechanisms of rheostasis (HiTime)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Norway
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2161246.0
EU funding (EUR): 2161246.0
Participants: 1
Project status: SIGNED

HiTime is a project about the adjustment of homeostatic set points in physiology. This is known as rheostasis and is of core importance for transitions between physiological states. I seek to develop the concept that a specialised cell type in the hypothalamus, the tanycyte, is the cellular embodiment of a rheostat, and that by understanding the function of the tanycyte, we will gain fundamental insights into hypothalamic control of rheostasis. Since rheostasis is weak in laboratory mice bred to live in constant laboratory environments, new paradigms must be developed. I will therefore investigate tanycyte function in the context of seasonal deep hibernation: the most dramatic example of rheostatic control of energy metabolism in mammals. I will use the golden hamster as the study organism because it has an excellent combination of attributes for pursuing the project aims, from experimental tractability to availability of molecular resources. The study approach will exploit advanced telemetry combined with transcriptomics, metabolomics and neuroimaging to develop an unprecedented “arrow of time” description of changes in tanycyte status in relation to peripheral and central changes in energy metabolites throughout the hibernation. This approach will encompass both long-term rheostatic control of seasonal entry and exit from hibernation, and short-term rheostatic control of torpor-arousal cycles during the hibernation phase. In parallel, I will develop neurogenetic and micro-infusion approaches to allow characterisation of the causal events in rheostatic hibernation control. My career track record gives me an unusual combination of in vivo physiology and bioinformatics skills, which, in combination with my pilot studies establishing new techniques, gives an excellent chance of success despite high ambition. This success will have reciprocal benefits for two major interest areas in physiology with impacts from human obesity research to interplanetary space travel.

Keywords: tanycytes,seasonal,thyroid hormone,hibernation,torpor,omics,aav
MEDITERRANEAN RESEARCHERS' NIGHT (2022 AND 2023 EDITIONS) (MEDNIGHT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Greece,Spain,Cyprus,Türkiye,Belgium,Italy
Call: European Researchers' Night 2022-2023 (HORIZON-MSCA-2022-CITIZENS-01, 2022)
Start date: 2022-03-08
End date: 2023-11-07
Duration (months): 20.0
Total project cost (EUR): 650990.86
EU funding (EUR): 599696.0
Participants: 10
Project status: CLOSED

More than 500 million people on three continents are united by the world's largest sea, the Mediterranean. Our strategic geographic location and the shared history gives us a common character and common challenges. Mediterranean Researchers' Night - MEDNIGHT objective is to generate a Mediterranean unity, providing awareness about common problems, fostering scientific careers, reinforcing researchers’ commitment and progress, and putting science and scientists at the cornerstone of our future and a relevant matter. MEDNIGHT shows the attractiveness and importance of the researchers’ work and professions to the general public, and specially for girls and boys, carrying out a series of activities framed under the common umbrella of what we have come to call “Mediterranean Science” placing particular emphasis on youngsters and female researchers and showing the potential of R&D as a source of progress and well-being. Mediterranean Science relates to research developed in the our territories but also the countless collaborations with other EU researchers. Mediterranean Science is focused on Mediterranean relevant topics according to our culture, way of life or current challenges: Sea and pollution, Climate and clean energies, Diet and nutrition, life and Health. Many online and face-to-face diverse activities are organised by MEDNIGHT consortium in Valencia, San Juan, Orihuela, Torrevieja, Messina, Lesvos, Nicosia, Istanbul (Main cities), and also Lliria, Santa Pola, Limnos, Rhodes, Syros Eyupsultan, Kadikov, or El Cairo, among others (Satellite cities).

Keywords: mediterranean science,scientific vocations,engagement,gender gap,scientifi communication
Obesity: Biological, socioCultural, and environmental risk Trajectories (OBCT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Netherlands,Norway,United Kingdom,Poland,Ireland,Denmark,Finland,Spain
Call: Prevention of obesity throughout the life course (HORIZON-HLTH-2022-STAYHLTH-01-two-stage, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 8131297.5
EU funding (EUR): 8131295.0
Participants: 12
Project status: SIGNED

Obesity in Europe disproportionately affects people and communities with a lower socioeconomic position (SEP). Effective preventive approaches require consideration of the complex and dynamic interplay between (SEP-specific) biological, sociocultural and environmental risk factors of obesity across the life course. OBCT provides health professionals, researchers, policy makers and the public with knowledge, maps and tools to support sustainable prevention of obesity, with a particular focus on low SEP communities. To achieve this, we quantify the contribution of biological, sociocultural and built environmental risk factors of obesity risks and the interactions in and across various life stages, and translate the resulting knowledge into practical and effective tools for action. Specifically, OBCT will: 1) Advance the current understanding of obesity risks and predictors, and the role of SEP across the life-course; 2) Determine the importance of specific obesity-related behaviours to prevent obesity at key life stage transitions; 3) Develop a holistic obesity risk screener for use by the public at large and by health professionals; 4) Provide country-specific estimates of trends obesity; 5) Provide a digital atlas on the obesogenicity of environments; 6) Characterise obesity-related cardiometabolic risk profiles over gender, age and SEP; 7) Develop tailored lifestyle recommendations; 8) Determine the impact of obesity-related policies on inequality; 9) Provide a decision support dashboard for policy makers; 10) Provide co-developed toolboxes to support implementation of policy recommendations in low-SEP communities. OBCT’s outputs highlight where and in which domains obesity is to be targeted, and empower the research community, policymakers, health professionals and citizens to adapt and implement policies to reduce obesity risk, thereby helping to prevent obesity -particularly in low SEP communities - throughout Europe.

Keywords: obesity socioeconomic position life course primary prevention policy lifestyle behaviours sociocultural factors obesogenic environments risk screener inequalities co creation implementation
AIR TRAFFIC MANAGEMENT AND COMMUNICATION OVER ATN/IPS (ATMACA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Türkiye,Spain,Italy,France,United Kingdom
Call: ATM application-oriented research for air–ground integration and autonomy (HORIZON-SESAR-2023-DES-ER-02, 2023)
Start date: 2024-09-01
End date: 2027-02-28
Duration (months): 30.0
Total project cost (EUR): 1612187.5
EU funding (EUR): 1612187.5
Participants: 7
Project status: SIGNED

Air-to-ground communication technology is at the heart of the end-to-end air traffic management concept, which requires the global integration of current, future, and emerging communication networks. The present ATMACA (Air Traffic Management and Communication over ATN/IPS) project addresses an innovative solution enabling effective, seamless, interoperable air-to-ground datalink communication technologies and digital flight monitoring and management environment through aeronautical telecommunication (ATN) based on internet protocol suite (IPS) within all domains of flight. In this frame, ATMACA project aims at supporting “air-ground integration and autonomy” innovation flagship in the Strategic Research and Innovation Agenda (SRIA) presenting the strategic roadmaps to achieve SESAR phase D “Digital European Sky” in European ATM Master Plan 2020 edition. ATMACA proposes a beyond the state-of-the-art IP-based datalink communication solution by introducing an application-layer mobility management for ATN and enabling commercial of-the-shelf equipment. It will also provide a next generation human machine interface (HMI) which will process higher quality data, enable interactions with the existing and future aeronautical applications and services, and meet the needs of end-users. ATMACA solution will be validated based on real-time simulations and real-time monitoring tests by considering relevant applicable SESAR key performance areas and indicators as well as industry standards. The consortium consists of a balanced mixed of universities and industrial partners (an air navigation service provider, an airline and a research and consultancy firm specialized in HMI design) to ensure the achievement of the project objectives. ATMACA project’s outcomes will deliver a robust and reliable communication and ATM solution serving as a baseline for the future ATN and next SESAR ATM solutions.

Keywords: air traffic control,aeronautical communication,ip networks,data link technologies,mobile ip
Study of Novel Generation nanobodies for agri-food applications (GuardAgents)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Greece,Türkiye,Czechia,Serbia
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2025-11-01
End date: 2029-10-31
Duration (months): 48.0
Total project cost (EUR): 2099190.0
EU funding (EUR): 1738470.0
Participants: 6
Project status: SIGNED

The use of pesticides on crops presents a significant risk of consumer exposure to harmful chemical residues, underscoring the need to explore safer alternatives for both humans and plants. GuardAgents will address this challenge by developing new biopesticides that target the Cucumber Mosaic Virus (CMV), a major threat to crops around the world. GuardAgents will develop a new generation of efficient, cost-effective small antibodies, so-called nanobodies to enhance plant immunity, reduce pesticide dependency and contribute significantly toward sustainable agriculture. GuardAgents will also advance technological innovation in plant protection, minimize ecological impact, and foster long-term agricultural sustainability. A multidisciplinary, state-of-the-art approach will be employed producing recombinant nanobodies through in vitro and in vivo approaches involving E. coli and plants, followed by biophysical characterization using advanced analytical techniques. Molecular farming techniques will be applied to produce nanobodies in plants, followed by functional comparisons to in vitro-produced nanobodies. The antiviral efficacy of the developed nanobodies will be tested in plants through transient expression and transformation. Additionally, toxicity studies will be performed involving plant cell cultures, invertebrate and vertebrate animals, while environmental impact assessments will be conducted to ensure biosafety. This research seeks to optimize nanobody-based strategies for sustainable viral disease control in crops.

Keywords: nanobodies,biopesticides,sustainable agriculture
Revealing the neural computations that distinguish imagination from reality (MonitoringReality)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1477920.0
EU funding (EUR): 1477920.0
Participants: 1
Project status: SIGNED

Our brain is able to turn external signals coming into our senses into a vivid and coherent experience of reality. At the same time, our brain is also able to generate sensory experience in the absence of external signals via imagination. Contrary to our intuition, our experience of reality is not an objective reflection of the external world, since the brain has no direct access to that. Instead, what we perceive as reality is an inference that the brain makes about its own activity, which is both externally driven (by sensory input) and internally driven (by imagination). Recent research has shown that imagining something leads to similar patterns of brain activity as perceiving that same thing in reality. This raises the question; how does the brain determine whether activity represents reality or imagination? I hypothesize that to distinguish imagination and reality, the brain relies on a perceptual reality monitoring process where higher-order brain regions infer perceptual reality when sensory signals are strong enough and there is low cognitive control. I propose to test this idea by answering three complementary questions: (a) how does sensory processing influence reality judgements? (b) how does cognitive control influence reality judgements? and (c) how are different signals integrated and evaluated to form reality judgements? To answer these questions, I will use a novel psychophysical paradigm to experimentally induce confusions between imagery and perception in healthy participants. I will precisely characterize neural processes during these confusions by combining state-of-the-art techniques (high-field fMRI, MEG and tRNS), with advanced computational methods (multivariate decoding and Bayesian modelling). The results of this project will increase our fundamental understanding of core cognitive processes such as perception and memory and will provide a novel perspective on disorders of reality monitoring such as psychosis.

Keywords: mental imagery,perception,neuroimaging,reality monitoring,metacognition
Dispatchable concentrated Solar-to-X energy solution for high penetration of renewable energy Hop-On (SOLARX HOP-ON)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Spain,Cyprus
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 24.0
Total project cost (EUR): 364625.0
EU funding (EUR): 364625.0
Participants: 2
Project status: SIGNED

To tackle the long-term temperature goal of limiting global warming below 1.5 degrees Celcius and achieve a carbon-negative world by mid-century, the SolarX project integrates and performs synergistic management of a single, multiple-output concentrated solar tower facility that produces heat, electricity, or hydrogen (H2) depending on real-time energy demands and market prices. This enables enhanced flexibility and dispatchability, boosting the green transition to high Renewable Energy Systems (RES) penetration scenarios. To this end, SolarX focuses on the development and demonstration at a laboratory scale of three key enabling technological elements (KTE’s): a smart solar resource management algorithm (SRMA) aiming to meet the local instantaneous energy demands, a high-efficiency Concentrating Photovoltaic (CPV) receiver, and a carbon-negative bi-energy H2 receiver. The SolarX-Hop-On focuses on significantly enhancing the first key enabling element of the SolarX project, i.e. the SRMA, by: - Developing a patented, airborne, Unmanned Aerial Vehicles (UAV) based system for the continuous monitoring of the Light Collection and Concentration (LCC) sub-system of the solar tower plant. - Testing the continuous monitoring system in a relevant environment, thereby achieving a Technology Readiness Level (TRL) of 4 for the system, and - Tune the aligning of the input/output (I/O) data interface of the pilot accordingly in order to make it SRMA workflow-ready

Keywords: concentrated solar thermal unmanned aerial vehicles drones in renewables heliostat field efficiency optimization remote sensing
Industrial Policy and Corporate Connections (IPconnect)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 232916.16
EU funding (EUR): 232916.16
Participants: 1
Project status: SIGNED

The recent rise of industrial policy (IP) worldwide is reshaping the role of the state in the economy. A key challenge for industrial policy is to involve industrial groups in policymaking and implementation without allowing them to dominate the process. The main objective of this project is to study whether corporate connections of bureaucrats are beneficial or detrimental to the design of IP with the specific objective to promote private capital transfer from one region to another. This project leverages one of the largest state-led investment programs in recent history, employing quasi-experimental methods to credibly estimate causal effects in combination with high quality administrative data. It studies the German Treuhand agency that sought to transform East Germany’s troubled state-owned enterprises suffering from low labour and energy productivity in the wake of the German reunification. The agency’s leaders, recruited from West Germany’s business elite, were tasked with attracting Western capital. However, their close connections to West German businesses raised concerns about potential conflicts of interest. This project evaluates the effectiveness of the regional capital flow through connections, first, by assessing the performance of firms acquired by connected and unconnected investors. Second, drawing on detailed data on sales contracts, the project estimates the effect of connections on transaction outcomes. Third, it assess the impact on connections on the performance of corporate investors that participated in the large-scale investment program. The project's findings will be pertinent for the design of institutional policies around the avoidance of conflicts of interest in industrial policy.

Keywords: industrial policy,bureaucracy,connections
Planar CAPacitors for high temperature and mid-frequency operation (P.CAP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Portugal
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2022-10-01
End date: 2026-03-31
Duration (months): 42.0
Total project cost (EUR): 2468750.0
EU funding (EUR): 2468750.0
Participants: 1
Project status: SIGNED

Capacitors are ubiquitous in any electronic device, with aluminium and tantalum electrolytic capacitors used whenever larger capacitances are required. However, they suffer from reliability issues, especially when operating at high temperatures: a temperature increase of 10 ºC halves their life. In the case of tantalum there is an additional concern: it is considered a critical raw material that generates environmental and societal concerns and it has been gaining a lot of attention from capacitor manufacturers in the search for an alternative technology solution. P.CAP project brings an alternative to aluminium and tantalum electrolytic capacitors: planar electric double layer capacitors (P.EDLCs) with enhanced performance at mid frequencies and high temperature. EDLCs are energy storage devices with a much larger DC capacitance than capacitors and excellent cyclability, but current technology behave as resistors at frequencies greater than 1 Hz. Under the right conditions, we have proven that they can operate at higher frequencies (1-200 Hz) while maintaining the merits of EDLCs: large capacitance and extended lifetime. Moreover, when thermally stable ionic liquids are used as electrolyte, they can operate at temperatures above 200 ºC. In the P.CAP project, a TRL7 prototype bipolar capacitor that can operate at >250 ºC, with an operating life of more than 1000 h at this temperature and a rated voltage above 40 V, will be manufactured. This prototype will be used as a minimum viable product to validate the device in applications where reliability and high-temperature are required, such as mining and electric vehicles. The main project goal is to reach a pre-commercial stage with a clear roadmap for upscaling production and start pilot testing during the project. Our long term vision is to further miniaturise the technology and provide a tantalum-free solution for smartphones, tablets and printed circuit boards used in all electronic equipment.

Keywords: aluminium tantalum electrolytic capacitors