Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Structural investigation of interplay between epigenetics, transcriptional regulation and DNA damage (EPIDNA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

In eukaryotic cells, gene expression is regulated by a complex interplay between a number of factors, from large-scale chromatin accessibility to inducible enhancers or repressors to local DNA modifications, changes in nucleosome architecture and specific histone markers. These finely tuned factors coordinate embrional development, response to stimuli and changes in cell fate. At the same time, this regulatory network has to robustly accommodate random events, most notably the presence of DNA damage and the action of DNA repair factors. While recent reports suggest this interplay is not always smooth, our mechanistic understanding of the underlying processes is severely limited, highlighting the need for quantitative approaches that will yield predictive models. In this proposal, I plan to investigate three aspects of this interplay that recently came into the spotlight. Firstly, an integrative computational and experimental approach will be used to quantify the positioning effect resulting from a range of common DNA modifications: regulatory base variants that can be used to enforce specific nucleosome patterns, and damage byproducts that would thereby interfere with DNA repair through altered exposure to the environment. Secondly, a number of transcription factors will be systematically assessed to detect ones sensitive to the presence of the most common oxidative lesion, 8-oxoguanine, to identify possible direct cross-talk between oxidative stress and transcriptional regulation at oxidative hot spots. Finally, a multiscale quantum/classical study will explore the thermodynamics, mechanism of formation and possible nucleosomal locations of covalent histone-DNA cross-links that were recently postulated to both mediate the regulatory role of 5-formylcytosine and accelerate strand scission at abasic sites.

Keywords: dna damage
Linking extensive husbandry practices to the intrinsic quality of pork and broiler meat (mEATquality)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Germany,Spain,Spain,Spain,Italy,Italy,Germany,Poland,Poland,France,Netherlands,Netherlands,Netherlands,Denmark,Denmark
Call: Husbandry for quality and sustainability (H2020-FNR-2020-2, 2020)
Start date: 2021-10-01
End date: 2025-09-30
Duration (months): 48.0
Total project cost (EUR): 5994990.0
EU funding (EUR): 5994990.0
Participants: 18
Project status: SIGNED

The mEATquality project aims to provide consumers with quality pork and broiler meat, by developing novel solutions that address societal demands, environmental concerns and economic needs on farm and in the chain. The ‘extensiveness’ of production is a key issue, and will be developed in a stepwise approach. The first step surveys extensive husbandry factors in relation to intrinsic meat quality, through data collection on conventional, free-range and organic farms, and through consumer expectation studies. The second will include controlled experiments on-farm to investigate intrinsic meat quality characteristics in relation to husbandry factors: genetics, forage, space and enrichment. It will also develop innovative techniques for automated meat quality assessment at high line speeds, and combat food fraud through authentication of the final product via ‘fingerprinting techniques’ and blockchain technology. The third step will check the novel farming practices against sustainability aspects: animal welfare, environmental impact and economic viability. Market acceptance of the new products and ways to communicate them to consumers will be studied. The fourth and final step will communicate and disseminate the results. Key outputs are an ‘Extensive Practices’ app, animated movies and EIP Practice Abstracts for farmers, educational tutorials for consumers, retailers and restaurants, and an EU Meat Database for authentication purposes. mEATquality is proposed and co-designed by organic sector representatives Ecovalia and Naturland, in collaboration with CLITRAVI, the Liaison Centre for the Meat Processing Industry in the European Union. They joined forces with academic partners (including 5 of Europe’s leading meat quality laboratories), Marel (poultry, fish, meat & further processing equipment) and poultry breeder Hubbard. Finally, Plukon Food Group supports the project in-kind. Collectively these partners span the chain from Farm to Fork

Keywords: pig husbandry,poultry husbandry,meat quality,meat authenticity
Nuclear envelope attachment and dynamics of Human telomeres - unravelling nuclear organization (TeloHOOK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-11-01
End date: 2022-10-31
Duration (months): 60.0
Total project cost (EUR): 1795010.0
EU funding (EUR): 1795010.0
Participants: 1
Project status: CLOSED

The spatial and temporal organization of the nucleus and its components are essential for genome regulation. During interphase of mammalian cells the nuclear envelope maintains the shape and the mechanical integrity of the nucleus, but also provides an anchor for chromatin that is connected to its inner side. This interaction mediates the regulation of gene expression, DNA replication and the maintenance of genome stability. In human cells I found that a large subset of telomeres, the natural ends of linear chromosomes, are transiently anchored to the nuclear envelope specifically during postmitotic nuclear assembly. Chromatin organization undergoes extensive changes during progression through the cell cycle, particularly during mitosis with the nuclear envelope breakdown and the compaction of chromatin into metaphase chromosomes. The interaction between chromosome ends and the nuclear envelope at the stage where the nucleus is reforming post-mitosis suggests a new role for telomeres in nuclear organization. My aims are 1) to screen for interacting partners that mediate the cell-cycle dependent telomere tethering to the nuclear membrane; 2) to unravel the molecular mechanism of telomere-nuclear envelope association over the cell cycle by combining biochemistry and state-of-the-art microscopy; 3) to map the subset of chromosomes which ends are tethered using subtelomere specific FISH probes and determine whether they are conserved throughout cell divisions and if it plays a role in organizing chromosome territories; 4) to examine telomere dynamics in cells from premature aging syndromes affecting the nuclear envelope integrity using live imaging confocal microscopy, and understand the connection between telomeres, nuclear envelope, and aging. The originality of my scientific approach is to combine state-of-the-art cell biology, biochemistry, and molecular biology for an integrated view of human telomere function in nuclear organization.

Keywords: telomeres,genome organization,nuclear envelope,aging,dynamics
European Diplomacy Practices post-Lisbon: Adding Value through Cooperation (EuroDipl)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

“European Diplomacy Practices post-Lisbon: Adding Value through Cooperation” (EuroDipl) aims to assess the impact and significance of new European diplomatic practices in third countries between the EU and its member states after the ratification of the Lisbon Treaty (2009). It asks how, if at all, increased European cooperation in third countries has impacted European foreign policy-making. In doing so, the project seeks to suggest ways in which the the effectiveness and legitimacy of the emergent European diplomatic system might be strengthened, especially in times when changing strategic and geopolitical contexts challenge Europe’s role in the world. The EuroDipl objectives are to 1. contribute to the conceptual, theoretical and methodological innovation in studies of European diplomatic practice, 2. explain the impact of post-Lisbon European diplomatic practice on European foreign policy, and 3. improve the cross-fertilization between policy practice and academic research. Those objectives will be achieved through a mixed-methods approach that combines a mapping of diplomatic practices via a quantitative social network analysis (WP1) with a qualitative comparative case study design to investigate the impact of European diplomatic practices (WP2). These research activities will be enriched by regular policy influence and public engagement activities (WP3) and training (WP4). EuroDipl offers an innovation to the study of European diplomatic cooperation and best practices in bringing research and practice together. It advances the career of the researcher through professionalisation (data management, communication strategy, project management) and methodological training. The University of Bristol and its School of Sociology, Politics and International Studies (SPAIS), due to their experience in postdoctoral hosting and project management, and the supervision by Dr. Juncos and other SPAIS academics provide an excellent and stimulating environment for this project.

Keywords: european diplomacy,european foreign policy,european cooperation,european external action service,eu delegation
Nanofiber-Trapped Cold Atoms and Applications (NANOFI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 2
Project status: CLOSED

An important challenge for quantum information networks is the development of efficient quantum memories and sources of single-photons. A promising category of such devices is based on ensembles of neutral atoms. The motivation comes from the fact that collective effects related to large number of atoms make it much easier in principle to achieve a strong and controllable coupling between the medium and the light. The present project aims at performing such experiments based on an ensemble of cold atoms trapped in the vicinity of a nanofiber, which will enable to obtain a larger optical thickness, a better coupling between collective excitations and light modes and thus a larger efficiency than previous ensemble-based implementations.

Keywords: quantum memories,single photon sources,quantum information science,quantum cryptography,quantum communication,nanofiber,neutral atoms,entanglement
unrAvelLing sLow modE travelinG and tRaffic: with innOvative data to a new transportation and traffic theory for pedestrians and bicycles (ALLEGRO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-11-01
End date: 2020-10-31
Duration (months): 60.0
Total project cost (EUR): 2458699.7
EU funding (EUR): 2458699.7
Participants: 1
Project status: CLOSED

A major challenge in contemporary traffic and transportation theory is having a comprehensive understanding of pedestrians and cyclists behaviour. This is notoriously hard to observe, since sensors providing abundant and detailed information about key variables characterising this behaviour have not been available until very recently. The behaviour is also far more complex than that of the much better understood fast mode. This is due to the many degrees of freedom in decision-making, the interactions among slow traffic participants that are more involved and far less guided by traffic rules and regulations than those between car-drivers, and the many fascinating but complex phenomena in slow traffic flows (self-organised patterns, turbulence, spontaneous phase transitions, herding, etc.) that are very hard to predict accurately. With slow traffic modes gaining ground in terms of mode share in many cities, lack of empirical insights, behavioural theories, predictively valid analytical and simulation models, and tools to support planning, design, management and control is posing a major societal problem as well: examples of major accidents due to bad planning, organisation and management of events are manifold, as are locations where safety of slow modes is a serious issue due to interactions with fast modes. This programme is geared towards establishing a comprehensive theory of slow mode traffic behaviour, considering the different behavioural levels relevant for understanding, reproducing and predicting slow mode traffic flows in cities. The levels deal with walking and cycling operations, activity scheduling and travel behaviour, and knowledge representation and learning. Major scientific breakthroughs are expected at each of these levels, in terms of theory and modelling, by using innovative (big) data collection and experimentation, analysis and fusion techniques, including social media data analytics, using augmented reality, and remote and crowd sensing.

Keywords: pedestrian flow theory,bicycle flow theory,travel behaviour,activity scheduling,learning and memory decay,sustainable transport,crowd management,urban traffic
Revealing Sources of Gendered Parenthood: A multi-method comparative study of the transition to parenthood in same-sex and different-sex couples (GENPARENT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: Sweden,Netherlands,United States
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-08-01
End date: 2024-07-31
Duration (months): 72.0
Total project cost (EUR): 1999910.0
EU funding (EUR): 1787875.52
Participants: 3
Project status: SIGNED

This project is the first to apply an inclusive, internationally comparative, multi-methods approach to families to reveal the complex processes that result in a gendered division of work. We do this by comparing different-sex couples (DSC) to same-sex couples (SSC) focusing on the transition to parenthood and its career related consequences based on unique, population register data, census data and surveys, as well in depth interviews with couples. Three sub-projects emerge. In GENPARENT NORTH, longitudinal analyses of register data for the full population in the Nordic countries enable unique studies of the division of work and care in DSC and female SSC in a most similar-case comparison where the couples are matched on important background characteristics. In GENPARENT REGIME, the Nordic countries, the Netherlands and the US are compared in cross-sectional, quantitative analyses of female and male SSC and DSC with biological or adoptive children, their division of paid/unpaid work and the resulting career trajectories. Preliminary analyses indicate that family leave policies apply to some but not all families and this clearly structures the division of work and earnings in them. In GENPARENT VOICE, in-depth interviews with female and male SSC (planning for or having children) and adoptive DSC parents are carried out in order to explore the reasoning and expectations that precede the realized divisions of child care and paid work. In addition, the legal and social issues facing these families is highlighted. Interviews are conducted in Sweden and the Netherlands and for these countries, we have unique, longitudinal in-depth interviews with DSC expecting and having their first child. By comparing SSC to DSC and combining cross-sectional and longitudinal quantitative analyses with in-depth interviews, the GENPARENT project critically evaluate and develop theories on the gendered transition to parenthood, while expanding on and updating the welfare regime framework.

Keywords: gender,motherhood,fatherhood,care,identity,careers,work interuption,earnings,welfare regime,social policy,country comparison
CYBER Security InSURancE — A Framework for Liability Based Trust (CyberSure)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Cyprus,Greece,Greece,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-01-01
End date: 2021-12-31
Duration (months): 60.0
Total project cost (EUR): 1647000.0
EU funding (EUR): 1647000.0
Participants: 7
Project status: SIGNED

CyberSure is a programme of collaborations and exchanges between researchers aimed at developing a framework for creating and managing cyber insurance policy for cyber systems. The purpose of creating such policies will be to enhance the trustworthiness of cyber systems and provide a sound basis for liability in cases of security and privacy breaches in them. The framework will be supported by a platform of tools enabling an integrated risk cyber system security risk analysis, certification and cyber insurance, based on the analysis of objective evidence during the operation of such systems. CyberSure will develop its cyber insurance platform at TRL-7 by building upon and integrating state of the art tools, methods and techniques. These will include: (1) the state of the art continuous certification infrastructure (tools) for cloud services developed by the EU project CUMULUS; (2) the risk management tool of NIS enhanced by the NESSOS risk management methodology; and (3) insurance management tools of HELLAS. The development of the CyberSure platform will be driven by certification, risk analysis and cyber insurance scenarios for cyber system pilots providing cloud and e-health services. Through these, CyberSure will address the conditions required for offering effective cyber insurance for interoperable service chains cutting across application domains and jurisdictions.

Keywords: cyber insurance,security certification,security risk analysis,cloud services,e health
Modelling and strategies for the assessment and OPtimisation of Energy USage aspects of rail innovation (OPEUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Germany,Spain,Belgium,France,France,United Kingdom
Call: Energy usage, generation and saving approaches (H2020-S2RJU-OC-2015-01-2, 2015)
Start date: 2016-11-01
End date: 2019-10-31
Duration (months): 36.0
Total project cost (EUR): 797130.0
EU funding (EUR): 797130.0
Participants: 6
Project status: CLOSED

The aim of OPEUS is to develop a simulation methodology and accompanying modelling tool to evaluate, improve and optimise the energy consumption of rail systems with a particular focus on in-vehicle innovation. The OPEUS concept is based on the need to understand and measure the energy being used by each of the relevant components of the rail system and in particular the vehicle. This includes the energy losses in the traction chain, the use of technologies to reduce these and to optimise energy consumption (e.g. ESSs). Specifically, the OPEUS approach has three components at its core: i) the energy simulation model ii) the energy use requirements (e.g. duty cycles) and iii) the energy usage outlook and optimisation strategies recommendation. The concept builds on an extensive range of knowledge and outcomes generated by a number of key collaborative projects (e.g. CleanER-D, MERLIN, OSIRIS, RailEnergy, ROLL2RAIL) underpinning the research proposed, ALL of which have been led by OPEUS consortium members. Particularly the tool developed for the CleanER-D project will be used as starting point. Significant complementary work from the academic community will also be used to enhance the activities of the project. Specifically, these previous projects input will be used to: • Expand and develop the simulation tool (CleanER-D, MERLIN); • Complete the operational requirements by enhancing the urban duty cycles (OSiRIS); • Provide a global vision of energy consumption in railways (CleanER-D, OSIRIS, RailEnergy) OPEUS’ ambition is to firmly contribute to the following key areas: • Understand energy consumption of urban railways; • Develop a tool to objectively compare technologies and strategies aimed at optimising the energy usage of railway systems; • Unlock the potential contribution that novel technologies and associated strategies can make to optimising rail energy consumption; • Share a global vision for how energy is used in railways

Keywords: energy usage,modelling,global vision,systems approach,optimisation strategies,traction chain losses