Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reconstituting the Acceptance and Daily Integration of Technology: X-Rays in the Late Ottoman Empire and Republic of Turkey, 1895 to Present (RADIATE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-15
End date: 2027-09-14
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Titled “Reconstituting the Acceptance and Daily Integration of Technology: X-Rays in the Late Ottoman Empire and Republic of Turkey, 1895 to Present” (RADIATE), this project pioneers a new methodological approach to the study of technology in non-Western contexts. By tracing the longue-durée historical trajectory of X-ray technology, from its discovery by Wilhelm Conrad Roentgen in Germany to its widespread adoption in modern Turkey, RADIATE moves beyond conventional narratives that simply focus on the moment of its first introduction in the Ottoman Empire. Instead, it highlights the complex path X-ray technology took to gain acceptance, a journey marked by deep-rooted fears and societal anxieties, such as concerns about exposing the human body to invisible forces. The project explores the deeper and often overlooked economic and legal processes that helped transform X-ray technology from a foreign innovation into an integral part of daily life. Rather than treating X-ray machines as prepackaged technologies simply transplanted into the Ottoman world, RADIATE examines their gradual integration across different sectors of society despite initial scepticism and rejection. This includes investigating lesser-studied uses of X-rays beyond medicine, such as in industrial applications and border control – areas that have been almost entirely neglected in previous scholarship. By incorporating a diverse array of historical actors – ranging from technicians and marketers to investors and ordinary citizens – RADIATE challenges the traditional focus on elite scientific figures in the history of radiology. The project’s multidisciplinary and holistic approach aims to offer a groundbreaking understanding of how technology changed society – and how society changed technology.

Keywords: ottoman empire,turkey,x rays,radiology,radiotherapy,history of medicine
Participatory dEmocRacY that sCaLES (PERYCLES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Netherlands,Germany,Italy,Israel,United Kingdom,Romania,Greece
Call: Digital democracy (HORIZON-CL2-2024-DEMOCRACY-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 3271305.25
EU funding (EUR): 3271305.25
Participants: 10
Project status: SIGNED

Civil society and public authorities from all levels of government are increasingly turning to digital democracy tools to improve citizens’ participation in democratic processes and the legitimacy of policy decisions. At the same time, digital democracy technology today is not yet fit to meet the lofty goal of providing an all-round democratic infrastructure that can re-empower citizens and make public administrations more relevant and responsive to the citizenry’s wills and needs. This is because digital democratic technology is currently developed and deployed while we still lack evidence-based methods to design, assess and validate it. We still lack the know-how to discern which specific technological solutions best foster inclusive, meaningful and scalable democratic participation, and under what conditions. PERYCLES tackles the challenge of developing such know-how, analyzing and testing platform designs on an open-source software for democratic deliberation that can be deployed at multiple levels of governance: from local, to national, to transnational. To do so, we develop a first-of-its-kind interdisciplinary approach to the design of digital democracy technology, which integrates methods and concepts from democratic theory, the social sciences and the computing sciences. The outcome of the project will be threefold: first, a set of methods to assess digital democracy solutions in a principled manner; second, readily available open-source implementations of digital democracy solutions that meet the identified standards; third, a library of best practices and recommendations for the design and deployment of online participation platforms, targeting digital democracy practitioners, citizens and decision-makers.

Keywords: digital deliberation,scalability,inclusivity,safe participation,deliberation quality,representativity
Kits for advanced polymer-lipid nanocarriers for targeted delivery of RNAs to cardiac and skeletal muscle cells (POLIRNA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-10-01
End date: 2025-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Currently, RNA therapies are available on the clinics to treat liver diseases and as COVID-19 vaccines. Hence, their therapeutic potential still remains largely unexploited for the treatment of other disorders, such as age-related, rare genetic and infectious diseases. One key problem for effective preclinical research on new RNA therapies is the lack of safe, efficient and cell-specific delivery vehicles. Gold-standard cationic lipid transfection reagents suffer from dose-dependent cytotoxicity, inability for cell-targeted delivery and poor stability. Clinically approved lipid nanoparticles efficiently target liver cells, while attempts to target other cell types have achieved limited success. In POLIRNA I will develop and validate a new safe, efficient, and versatile platform for RNA release to target multiple cell types, based on ligand-functionalized polymer-lipid nanocarriers, by exploiting a new patented method from my ERC-funded project BIORECAR (772168). POLIRNA consists of “kits for research use”, allowing user-friendly preparation of nanocarriers able to effectively deliver non-coding RNAs (such as siRNAs and microRNAs) to target cardiomyocytes and skeletal muscle cells for preclinical research studies on cardiac regenerative medicine and muscle-related diseases (e.g., neuromuscular diseases). Technology development and validation will benefit from collaboration with major experts in the fields and companies supporting the innovation route from lab-to-market. My previous experience as coordinator of research and innovation projects and as co-founding member of an academic spin-off company, and the current involvement of my team in business plan competitions will drive the process of technology validation, with the aim to strengthen technology value proposition versus current gold-standard solutions, found a start-up company and attract investments.
Dynamic Instabilities, Small-scale Turbulence and impacts on the Stratosphere (DISTurbS) (DISTurbS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: SIGNED

The tropical upper troposphere and lower stratosphere (TUTLS) plays a critical role in the climate system as the gateway to the global stratosphere. Within this region, tropical upwelling, wave activity, and turbulence control stratospheric composition by modulating the vertical transport of aerosol and trace gases, and the formation of thin ice clouds, which are a net sink of water vapor. This complex interplay between dynamics and chemistry is challenging to simulate, and as a result, atmospheric models struggle to represent the composition of the lower stratosphere in the current and future climate. The proposed work uses diverse observational datasets collected by high-resolution radiosondes, high-altitude research aircraft, and superpressure balloons to understand the role of turbulence in this system, and to apply that knowledge to the improvement of atmospheric models. The work is divided into four parts: 1) quantifying the frequency of TUTLS turbulence and characterizing its variability, 2) investigating the effect of TUTLS turbulence on ice clouds, aerosol, and trace gases, 3) evaluating TUTLS turbulence in two different types of atmospheric models, and 4) developing a data-driven parameterization of TUTLS turbulence using machine learning. I will carry out my fellowship at Laboratoire de Météorologie Dynamique (LMD), in Palaiseau, France, under the supervision of Dr. Aurélien Podglajen. My experience with machine learning complements the host's expertise in the theory and measurement of turbulence, and familiarity with the datasets used for this work, facilitating a two-way transfer of knowledge. I will acquire new technical skills in observations and modelling, broaden my physical understanding of the atmosphere, contribute to the planning and execution of a large field campaign, and work with an international network of collaborators, which will critically support my professional ambition of leading my own research group.

Keywords: clear air turbulence,stratospheric composition,stratosphere troposphere exchange,observations of turbulence,machine learning,data driven parameterization,atmospheric modelling
Symbiotic Culture of Bacteria and Yeast Ecosystems for the development of Probiotic Extracellular Vesicles (SCOBY DO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

Fermented foods are used for many centuries all over the world for their contribution to longevity and digestive health. Regular consumption of fermented foods can combat dysbiosis and boost host’s immune response against various pathogens and associated diseases. However, they increase the microbiome of the digestive tract and can have adverse effects on immunosuppressed patients. Rather than single-strain probiotics, we will study Symbiotic Culture of Bacteria and Yeast Ecosystem (SCOBY) derived biomembrane-delimited nanostructures to obtain similar or enhanced beneficial effects. To that end, extracellular vesicles (EVs) harvested from kombucha, a fermented beverage based on tea and sugar produced with a SCOBY will be exploited for their antimicrobial properties against gastrointestinal bacterial infections and food-borne bacterial pathogens. The experienced researcher is a microbiologist with strong academic background in the field of microbiology, infectious diseases, and bioinformatics who will team-up with the Institute of Biosciences and BioResources with considerable expertise in EV research to carry out a uniquely interdisciplinary research program. The research will realize the following objectives: 1. to set-up and optimize kombucha SCOBY cultures for the production of EVs, 2. to study the role of SCOBY-derived EVs in interspecies communication and their impact on gastrointestinal bacterial pathogens, and 3. to synthetize molecularly imprinted polymers specific for the enrichment of SCOBY-EVs. To our knowledge, none of these objectives has been addressed before and they all have the potential to expand the knowledge in the field and drive the research towards biotechnology applications in health and disease. The research objectives are integrated with concerted training objectives in EV research, mass spectrometry, MIPs design and synthesis, outreach program, dissemination events and considerable knowledge transfer in microbiology from the researcher.

Keywords: novel foods,nano carriers,molecular delivery,extracellular vesicles,nanomaterials,biogenics,biomembranes,molecular characterization,proteomics,symbiotic culture,molecularly imprinted polymer
From fiber to wall: PHYSical approach of hygrothermal transfers in BIO-based construction MATerials (PHYSBIOMAT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Bio-based construction materials are air-fiber systems, such as wood, hemp, cellulose, flax, etc., possibly coated with a mineral paste. They represent a promising solution for carbon emission reduction, due to their low production cost and their partial or full recyclability. Moreover, they bring more comfort to the occupants thanks to their moisture-buffering capacity, and they require less energy for heating or cooling. These qualities are obtained through exchanges between water vapor and “bound water”, i.e., water absorbed in the solid structure, combined with heat transfers. Consequently, understanding and predicting water and heat (hygrothermal) transfers in such materials is essential to selecting them appropriately, adjusting their conditions of use, and designing innovative materials. However, the current analysis of their performance is generally based on limited evaluations at a global scale or via macroscopic models lacking physical information. My idea is instead to open the black box and start from the fiber scale, to explicitly describe the internal physical processes at this scale, including sorption dynamics, bound water diffusion, fiber configuration, etc., and then to progressively complete and extend this approach to full-scale materials. This can be used to build for the first time a generic description, understanding, and modelling, of hygrothermal phenomena in bio-based construction materials. This physical description will be supported and enriched by several experimental innovations. Notably, internal measurements of the spatial distribution of moisture content and temperature in time will be obtained from non-invasive time-resolved magnetic resonance imaging (MRI), which can be used to validate the models and determine diffusion properties in an unequivocal way. Finally, I will develop an open-source software predicting hygrothermal characteristics and performance based on material characteristics and history of ambient conditions.

Keywords: hygroscopic materials,moisture transfers,heat transfers,nmr,mri,modelling
Cancer tailored next generation cellular therapies (CATACLIS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: SIGNED

Cellular therapies are commonly used to treat hematological cancers but have yet to be established in solid oncology. Their evolution has been fuelled by hypotheses derived from cell biological observations in cancer models. Most approaches, however, will either never enter clinical development or fail clinical testing, often due to inadequate models of disease and their lack of relevance to human biology. In CATACLIS, I propose the first unbiased development of cellular products based on patient characteristics in order to address this enormous translational gap and ultimately provide more effective cell therapies to patients with solid cancers. CATACLIS will herald a paradigm shift in cell therapy by reversing conventional model-to-patient innovation ("forward translation") to patient-generated ideas tested in patient-derived models into clinical trials ("reverse translation"). I have discovered novel approaches to improve T cell function, which resulted in a clinical trial and established me as a leader in the field of cellular therapies. The challenge I will now face is to move beyond model bias and integrate cancer heterogeneity across patients and entities. In CATACLIS, I will use single cell data sets from patients to inform the design of next generation cellular therapies capable of overcoming current limitations in solid cancers, namely 1) access to tumor tissue, 2) target antigen(s) selection, and 3) immune suppression. To maximize clinical relevance, CATACLIS will use patient-derived materials from hypothesis generation to in vivo testing. This will enable me to create cellular products tailored to the patient´s cancer My research will not only result in novel cellular products for further testing and development toward clinical trials, but it will also serve as a resource for the development of innovative therapies based on patient data, contribute to the European open science objectives, and reduce the burden of animal experimentation.

Keywords: computational analysis car t cells chemokine receptors fusion proteins synthetic biology reverse translation
Stimuli-Responsive Mechanically Interlocked Peptide Rotaxanes for Biomaterials and Biosensing (MechPep)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

Mechanically interlocked molecules (MIMs) feature mechanical bonds, which link multiple distinct components together allowing free movement between them without dissociation. This makes MIMs perfect candidates for artificial molecular machines, and earned them the Nobel Prize in Chemistry 2016. Over the last 30 years, MIMs have been applied in diverse areas from switchable catalysis to smart materials. However, they have so far only found limited use in biomedicine, due to the often lengthy synthesis and poor solubility in biological media. Directly addressing these challenges, we will use Nature’s own building blocks (i.e. peptides) to construct stimuli-responsive MIMs for use in bioapplications. Rotaxanes are a class of MIM resembling dumbbells, with a macrocyclic ring encircling the axle. We will use bioactive peptides as the rotaxane axle (making them intrinsically biocompatible MIMs) whose bioactivity will be initially silenced via obstruction of the encircled stimuli-responsive macrocycle, which acts as “protective armour” and stabilises the peptide. Upon application of a stimulus (e.g. light irradiation), self-immolative cleavage of the macrocycle occurs, liberating the free peptide. Hence, light acts as a stimulus to turn-on the bioactive response of the peptide on-demand. We will use this to design advanced biosensing systems for stimuli-responsive MMP2 cleavage of the peptide sequence PLGLAG. Further, we will develop beyond state-of-the-art photopatterning methods for cell adhesion, using the integrin-binding RGDS peptide sequence as our rotaxane axle. Using the high spatiotemporal control of light, we can turn on cell-adhesion where desired via self-immolation of the macrocycle using light irradiation. This action represents a precise, high-resolution method for the photopatterning of cell-adhesive biomaterials, a crucial first step for the use of peptide-coated biomaterials in therapeutics e.g. transplants, skin-grafts, and drug delivery platforms.

Keywords: mechanical bonds,rotaxanes,mechanically interlocked molecules,stimuli responsive molecules,rgds,photopatterning,comformational analysis
Regional Variation in Social Norms and Climate Change Action (ClimaSoNo)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1479004.0
EU funding (EUR): 1479004.0
Participants: 1
Project status: SIGNED

A growing body of research in the behavioral and social sciences highlight the potentially productive role of social norms in changing behavior towards more climate change action. To date, we have been neglected significant aspects: the large regional variation in behavior and beliefs, creating a gap in our understanding of i) how people perceive others’ behavior and attitudes in their region, ii) what kind of individual and regional factors explain the variation in social norms, and iii) how regional social norms causally effect climate-friendly behavior across economically, socially, and culturally diverse regions. To comprehensive study theses aspects represents the major thrust of ClimaSoNo beyond the current state-of-the art, providing new insights about the extent and nature of the regional heterogeneity in social norms. ClimaSoNo promises to collect and analyze a rich set of new scientific data from a comparative survey across 130 regions in 12 countries. The cross-regional survey includes a novel technique to accurately measure perceived social norms at the regional level (Task 1). The empirical analysis of ClimaSoNo will systematically explore the potential determinants of regional variation in social norms related to support for climate policies and climate-friendly behavior (Task 2). Cross-regional experiments will be carried out to test whether this novel technique of measuring social norms can predict climate change action across regions. In this way, ClimaSoNo will produce an experimentally validated ‘survey module’, measuring support for policies, climate-friendly behavior and perceived social norms (Task 3). Finally, ClimaSoNo capitalizes on cross-regional experiments to estimate the causal effect of different types of regional social norms on climate-friendly behavior (Task 4). ClimaSoNo will mark a massive step forward to our understanding of the heterogeneity in human behavior and beliefs across regions and societies.

Keywords: social norms,individual support for climate policies,cross regional survey,economic experiments,experimental validation