Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Towards better Synchronisation of Priority Settings and Evaluation Mechanisms for Research Infrastructures Beyond National Relevance (InRoad)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Coordination and support actions
Countries involved: Ireland,Germany,Germany,Germany,Italy,Spain,Switzerland,Belgium,Poland,Switzerland,France,Czechia,Netherlands,Portugal
Call: Policy and international cooperation measures for research infrastructures (H2020-INFRASUPP-2016-1, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 2001983.75
EU funding (EUR): 1992983.75
Participants: 14
Project status: CLOSED

The main objective of the proposal is to contribute to a better harmonisation and synchronisation of priority-setting-, funding- evaluation and life-cycle management of Research Infrastructures (RI through the exchange of best practices among the main stakeholders in member states, associated countries and at European level. The regional dimension will explicitly be taken into account by integrating, where appropriate, smart specialisation strategies in the work carried out. InRoad will achieve this by a) the identification and dissemination of best-practices and common trends of national RI roadmapping procedures and of ex-ante, interim (monitoring) and ex-post evaluation of RI in Europe, b) establishing a trustful dialogue and an intensive exchange of information about national RI roadmapping procedures, RI monitoring and evaluation and sustainable approaches for RI, in line with the objectives laid out in the European Research Area communication and c)fostering a dialogue with the European Commission, ESFRI, the e-IRG and all relevant stakeholders at regional, national and European levels in order to discuss the project findings and promote the dissemination of its recommendations. The InRoad activities and objectives contribute to the specific challenge highlighted in the work programme by a) promoting comparability and synchronisation of national procedures and a possible harmonisation of ex-ante and ex-post evaluation mechanisms through a survey, case studies, interviews and theoretical analyses of current frameworks in use, in close cooperation with the relevant stakeholders, b) supporting RI policy development in terms of exchange of best practices for national roadmap drafting and evaluation procedures and c) support the information sharing with stakeholders in charge of priority-setting, evaluation, funding and operation of RI through their inclusion in a dedicated Reflection Group.

Keywords: research infrastructures,roadmapping,ex ante evaluation,ex post evaluation,business models,smart specialisations,esfri,e irg
Unsettling Remembering and Social Cohesion in Transnational Europe (UNREST)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Germany,Poland,Denmark,United Kingdom
Call: The cultural heritage of war in contemporary Europe (H2020-REFLECTIVE-SOCIETY-2015, 2015)
Start date: 2016-04-01
End date: 2019-03-31
Duration (months): 36.0
Total project cost (EUR): 2489648.75
EU funding (EUR): 2489648.75
Participants: 7
Project status: CLOSED

The main purpose of this project is to deliver new empirical yet also theoretically informed knowledge of those memory agents, practices and contexts capable of countering fixed and essentialist war and conflict memories, opening them to reflexive reinterpretation and change. Theoretically, the project will develop the concept of an agonistic ethico-political mode of remembering as distinct from the antagonistic and cosmopolitan modes, and provide a thick description of their defining characteristics. A related aim is to assess which of the two reflective modes, the cosmopolitan or the agonistic, best contributes to a shared European ethico-political framework and transnational solidarity. Empirically, the project will test the different ethico-political modes of remembering in contemporary heritage discourses and practices by different memory milieus located at various territorial scales in relation to some of the armed conflicts of the 20th century with an enduring legacy. By exploring the relationship between 1) the modes of remembering being negotiated and contested in various European settings; 2) the memory agents promoting them (heritage professionals, policy-makers, historians, creative artists, socio-political activists); and 3) material and immaterial heritage (museums, burial sites, media, visual and written culture), the project will assess how, why and in which contexts certain modes of remembering the violent past are able to prevail as well as their articulation with various territorial identities.

Keywords: theory of memory,mass grave exhumations,museum studies,memory studies,dark heritage,agonistic memory,spanish civil war,world war i,world war ii,balkan wars
Translational synergistic growth factor microenvironments for bone regeneration (SPRAYNERGY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-06-01
End date: 2017-11-30
Duration (months): 18.0
Total project cost (EUR): 148783.75
EU funding (EUR): 148783.0
Participants: 1
Project status: CLOSED

We propose a robust polymer-based system that allows a safer delivery of recombinant human bone morphogenetic protein-2 (rhBMP2) for bone tissue engineering. We have teamed up with a surgeon (Dr. Meek) and an SME (Taragenyx Ltd.) in the planning stages, for the appraisal of the proposal from a translational standpoint. Later, Taragenyx will also be involved with scaling-up and commercialisation. We filed a patent covering the technology, and licensed Taragenyx its exploitation. rhBMP2 is a powerful human growth factor (GF) essential in tissue morphogenesis and used to promote bone growth in clinical applications. Current clinical delivery has encountered serious complications associated with the high doses used. We have developed a system that allows the effective presentation of GFs in combination with the integrin binding domain of fibronectin (FN), promoting simultaneous and co-localised signalling between GF receptors and integrins. We have shown the ability of Poly(ethyl acrylate) PEA to organise FN and sequester rhBMP2 in synergy with the integrin binding region to direct stem cell differentiation. This technology enhances bone regeneration and vascularisation with lower rhBMP-2 doses. With this understanding we have engineered a system to regenerate a bone critical size defect in a murine model. Results were comparable to the higher doses used in the clinic, which makes the system safe, effective and more competitive than current commercial products. PEA is however a non-degradable material, a major hurdle to be overcome for many potential applications. We will fabricate a degradable construct spray-coated with a nanometric layer of this functional material to induce and direct bone growth – as already shown for the bulk polymer in our ERC Grant, and investigate in vivo the engineered systems. Overall, we will develop a safe and versatile bone system for clinical use in patients with non-union bone defects, and set a route towards commercialisation.

Keywords: scaffolds,bmp 2,fibronectin,stem cells,bone,coating,fabrication
Giants through Time: Towards a Comprehensive Giant Planet Climatology (GIANTCLIMES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-04-01
End date: 2024-03-31
Duration (months): 84.0
Total project cost (EUR): 1999815.0
EU funding (EUR): 1999815.0
Participants: 1
Project status: SIGNED

Giant planets serve as natural laboratories to explore the processes shaping planetary climate. The next five years will likely transform our understanding of the extreme environments of the outer Solar System, with the culmination of the Juno and Cassini missions to Jupiter and Saturn and the arrival of a new capability for ice giant science (James Webb Space Telescope, JWST). GIANTCLIMES will capitalise on this chance of a generation by assembling the first comprehensive climatology of all four giants. My programme will provide insights that no single mission can: exploring atmospheric variability over long time spans using an unprecedented multi-decade archive of ground-based observations; new data from space telescopes and planetary missions; combined with world-leading spectral analysis techniques and interpretive models. GIANTCLIMES consists of three objectives: 1. CLIMATE CYCLES: Assemble the first quasi-continuous record of Jovian climate over three decades to identify natural patterns of atmospheric variability to predict spectacular storm eruptions and global-scale transformations of its banded structure. 2. STRATOSPHERES: Explore the changing stratospheres of seasonal Saturn and non-seasonal Jupiter over long timescales to develop a new paradigm for the radiative, chemical and transport processes shaping these poorly-understood atmospheric regimes. 3. ICE GIANTS: Provide the benchmark for understanding the fundamental differences between Ice Giant and Gas Giant climate via existing Spitzer and Herschel observations of Uranus and Neptune, and produce the highly-anticipated first spatial maps of their stratospheres using JWST. These projects will explore planetary climates in all their guises, using comparative remote sensing studies to understand the forces defining their natural variability. New insights and discoveries from GIANTCLIMES will reinforce my leading role in the next generation of ambitious missions to explore the giant planets.

Keywords: planetary atmospheric science and climatology,ground and space based infrared observation
Adapter for a commercial grade camera or a smart phone to perform depth resolved imaging (AdaSmartRes)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-06-01
End date: 2018-11-30
Duration (months): 18.0
Total project cost (EUR): 149300.0
EU funding (EUR): 149300.0
Participants: 1
Project status: CLOSED

The proposal refers to a patented adapter that can transform a commercial grade digital camera or the camera in a smart phone into a depth resolved imaging instrument. Several adapters will be assembled, making use of optical coherence tomography (OCT) technology protected by some other of PI’s patents. The activity takes advantage of recent progress in commercial grade cameras in terms of their modes of operation as well as in terms of parameters of their devices, such as sensitivity and speed of their photodetector arrays. Three versions of low cost functional OCT systems will be assembled as proof of concepts responding to needs of three possible markets that can be addressed by such an adapter: 1. En-face depth resolved, high transversal resolution microscope; 2. Fast cross sectioning imager. 3. Swept source volumetric analyser. Industrial input comes from a company involved in professional eye imaging systems, a company already selling adapters for smart phones to perform medical imaging, a company specialised in digital photographic equipment and a company efficient in prototyping photonics equipment and handling medical images. Clinical input is provided by two specialists in the two highest potential medical imaging markets of the adapter serving ophthalmology and ear, nose and throat speciality.

Keywords: optical coherence tomography,adapter,smart phone,digital camera,depth resolved imaging
CIRCULATING TUMOR DNA AS AN EPIGENETIC BIOMARKER FOR TUMOR RESPONSE (INITIATOR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Belgium
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-08-01
End date: 2022-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Tumors are characterized by a disorganized vasculature, leading to profound levels of hypoxia. Normalizing the blood vessel formation (angiogenesis) in tumors has therefore become an attractive therapeutic strategy, leading to the development of approved drugs that inhibit major angiogenic pathways. Resistance however restricts the success of these anti-angiogenic drugs in some patients. There is thus a great clinical need for readily accessible markers that serve as reliably predictive biomarkers of anti-angiogenic therapies. However, all markers discovered to date have a limited predictive power. In the ERC Consolidator Grant CHAMELEON, we discovered how tumor hypoxia causes DNA hypermethylation and how changes in DNA methylation underlie resistance to anti-angiogenesis. Here, we propose to validate how methylation patterns detectable in plasma circulating free DNA from a prospective collection of patients with metastatic colorectal cancer can be used to predict an early response to anti-angiogenic therapies by using our in-house developed cfDNA co-methylation test, referred as the ‘INITIATOR’ test. If successful, we anticipate that this project will overcome many of the issues that are currently associated with anti-angiogenic drugs: cfDNA is readily accessible and can be serially sampled during treatment or follow-up, cfDNA also mirrors the entire tumor and not just the biopsied site, while the epigenetic changes detectable in cfDNA may be a dynamic representation of the tumor in response to treatment.

Keywords: liquid biopsy,dna methylation,cancer therapy,anti angiogenesis
Developing an anti-Myc cell-penetrating peptide for cancer treatment (GBM-CPP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-08-01
End date: 2017-07-31
Duration (months): 12.0
Total project cost (EUR): 147750.0
EU funding (EUR): 147750.0
Participants: 1
Project status: CLOSED

Despite ever-increasing investments in the development of new treatments, many cancers remain incurable. One reason is that most current therapies target redundant functions around which tumour cells can build resistance. We focus instead on a unique and essential cellular function: the Myc oncogene, deregulated in more than 70% of human cancers. Targeting Myc has long been considered unfeasible because of potentially catastrophic side effects. Against this dogma, using a Myc inhibitor called Omomyc, we showed that Myc inhibition displays extraordinary therapeutic benefit in various mouse models of cancer (e.g. lung, brain, pancreas and skin) and causes only mild and reversible side effects. Importantly, no resistance to Omomyc has been observed, and Omomyc constitutes the best Myc inhibitor known to date. Omomyc has so far been used only as a transgene and proof of principle. However, thanks to the ERC-2013-CoG n° 617473, we now have evidence that the Omomyc peptide has cell-penetrating activity, and reaches lung and brain upon nasal administration, where it exerts its anti-tumorigenic activity in cancer cells (data protected by a patent application EP13382167.8). Thus, the Omomyc peptide could become the first clinically viable direct Myc inhibitor to treat lung, brain and other types of cancer. Our overall project encompasses the preclinical development of the Omomyc peptide to reach Phase I/II clinical trials, at which point the technology will be transferred to a pharmaceutical company for further commercialization. Hence, in this ERC Proof of Concept application, we propose to achieve specific, essential early milestones for the pharmaceutical development of the Omomyc product that will de-risk it and noticeably increase its value and the probability of reaching the market.

Keywords: omomyc,cancer,therapeutic,peptide production,industrial scale,regulatory activities,derisking,feasibility study,business plan
Hydrowashr 2000 (HW2000)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Netherlands
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Hydrowashr has developed an all-in-one washing device which will save up to 99% of water each time someone uses it for washing their hands. Next to that it is a disruptive innovation in the sanitary market, in the light of environmental, economical, hygienically and aesthetic values. This proposal describes Hydrowashr’s innovation and why a feasibility study will be necessary to further develop, validate and commercialize the innovation: the HW2000. Hydrowashr has developed HW2000 (Hydrowashr 2000): a product, based on an innovative spraying system, which allows individuals to wash their hands in a more sustainable and hygienic way. How it works: the user puts his hands into the HW2000. The, completely touch free, washing process works with microscopic droplets of water that are fired on the skin trough a rapid flow of air. Then the hands are dried in the same air flow. After 20 seconds, the hands are clean, dry, warm and soft. Because of this new spraying technology, up to 99% water will be saved each time. At the same time the system cleans hands better than existing solutions, providing better hygiene. Hydrowashr B.V. has been founded in 2012 and is specialized in water technology. Hydrowashr is located in Leeuwarden, the ‘Capital of water technology’. In Leeuwarden the Water Campus allows companies to develop and test innovative water technologies. Fresh water is globally becoming a scarce resource. In a research of 2007, initiated by the European Commission, water scarcity and drought is identified as a growing European problem. According to the report, water savings will help addressing these problems. Additionally water savings will provide financial, economic, environmental and other additional benefits. The importance of innovative water solutions is also stressed by the fact that water is one of the main focus areas of the Horizon2020 work program "Climate action, environment, resource efficiency and raw materials Challenge".

Keywords: water technology,sanitary innovation,sustainable and hygienic all in one hand washing and drying
Next Europractice eXtended Technologies and Services: “The access point for the future generation of electronic components and systems” (NEXTS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Ireland,Germany,Belgium,France,United Kingdom
Call: Electronic Smart Systems (ESS) (H2020-ICT-2018-2, 2018)
Start date: 2019-01-01
End date: 2022-09-30
Duration (months): 45.0
Total project cost (EUR): 7989055.0
EU funding (EUR): 7989055.0
Participants: 5
Project status: CLOSED

The mission statement of NEXTS is to provide the European industry and academia with a platform to develop smart integrated systems, from advanced prototype design to volume production. The latter will be achieved by providing easy and affordable access to a wide range of fabrication technologies and tools complemented with training and support to the customer in all critical steps which are needed. NEXTS will act as a true one-stop shop for technologies enabling fully integrated systems and providing direct routes for industrial up-scaling of those systems and consequently it will sustain and grow jobs in Europe in the areas of design and fabrication of microelectronic component and systems. The partners of the NEXTS proposal have already a vast experience and strong position in providing access to microelectronic technologies. Its predecessor EUROPRACTICE has supported the European academic sector with CAD tools and IC prototyping for over 25 years, and its partners have already supported SMEs with MPW and small volume services for over 15 years. The new consortium has been extended with CMP (Circuits Multi Projects) and TYNDALL who will provide additional access to foundry services and more importantly to system integration capabilities. NEXTS will ensure that the European industry grows the captured value from the development, fabrication and deployment of electronic smart systems and remains a global leader. As a value chain aggregator, NEXTS aims to close the gap between the supply- and demand- side for electronic smart systems in virtually all applications domains. Therefore, it provides maximum transformative impact to all sides of the value chain.

Keywords: smart system integration,electronic components and system,cad tools,mpw prototyping service,stimulation of first time users,training and support