Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Genomic determinants of inflammation: from physical measurements to system perturbation and mathematical modeling (MODEL-IN)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: United Kingdom,United Kingdom,France,France,Italy,Israel,Germany
Call:  (FP7-HEALTH-2007-B, 2007)
Start date: 2008-12-01
End date: 2012-05-31
Duration (months): 42.0
Total project cost (EUR): 3962778.0
EU funding (EUR): 2926305.0
Participants: 11
Project status: CLOSED

Inflammation is a complex biochemical and cellular response essential for the viability of higher organisms because of its requirement in anti-microbial defence and protection from the consequences of tissue injury. However, uncontrolled or sustained inflammation leads to several diseases with a huge social impact, ranging from autoimmune diseases to septic shock and cancer. While the requirement for specific transcription factors (TF) in inflammatory gene transcription is known, quantitative models describing how their interactions with genomic sequences leads to normal or pathological outcomes are not available. Unravelling how genomic organization underlies the orchestrated expression of inflammatory genes is crucial to understand how to pharmacologically tune pathological inflammatory responses. Now is the right moment to tackle this question as for the first time we have genomic technologies and computational abilities to generate the necessary quantitative data and to build computational models describing spatiotemporal coordination of transcription of hundreds of inflammatory genes by multiple TFs. To implement this objective, we have assembled a consortium of top-level scientists in the European Research Area who reached documented excellence in complementary aspects of transcriptional control, namely quantitative measurement of TF-DNA interactions, in vitro and in vivo analysis of chromatin organization, manipulation of genomic sequences by homologous recombination, computational and systems biology applied to transcriptional circuits. The network provides the critical mass required to generate ample quantitative and complementary datasets describing the minimal transcriptional regulatory blocks relevant for inflammation, thus enabling the integration of their coordinated activities via systems approaches. Each research group complements the other participants and the whole projects, and as such this proposal can not be carried out on any individual level.

Keywords: multidisciplinary approaches,inflammation,quantitative data,system modelling
Bivalve conditioning and settlement – keys to competitive hatchery production (SETTLE)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: Norway,France,Spain,Spain,France,Ireland
Call:  (FP7-SME-2007-1, 2007)
Start date: 2008-10-01
End date: 2010-10-31
Duration (months): 25.0
Total project cost (EUR): 1853680.0
EU funding (EUR): 1406400.0
Participants: 10
Project status: CLOSED

Hatchery production of bivalves during autumn and winter (outside natural spawning season) is a challenge, but necessary to keep market shares and ensure sufficient seed supply to European growers on a year-round basis. The SETTLE project will focus on key events during hatchery production of flat oyster (Ostrea edulis) and great scallop (Pecten maximus) which are species native to Europe. The overall objective is to foster year-round production of spat in hatcheries by controlling gonad development and maximise larval metamorphosis and settlement. Flat oyster and great scallop are both highly valued and sought-after products on the European seafood market, but insufficient numbers of high quality seed severely hamper aquaculture development of this sector. Bivalve hatcheries (SMEs) in Spain, France, Ireland and Norway are looking to increase the availability of spat and will engage RTDs in Spain, France and Norway to solve selected problems related to broodstock conditioning and larval settlement. Successful intensive production of bivalve spat depends on predictable procedures for conditioning of broodstock (manipulation with feed, light and temperature) to induce spawning, breeding period, larval rearing and settlement. To solve the seasonal problems the SETTLE project will identify environmental factors leading to successful off-season broodstock conditioning, reveal effects of conditioning and other biological processes on settlement and optimise existing culture methods and technology. By extending the hatchery production season and obtaining new knowledge and technologies the SMEs will increase the available number of flat oyster and great scallop spat. A quantity and value increase 5-10 times of today’s level is anticipated within 5-7 years. This will strengthen the competitive position of the SMEs and increase the shellfish production in Europe significantly.

Keywords: aquaculture,bivalves,hatchery,broodstock,settlement,ostrea edulis,pecten maximus
Sub-surface Fast internal Engraving and Reading system for Anticounterfeiting applications (SFERA)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: France,France,Belgium,United Kingdom,Italy,Belgium
Call:  (FP7-SME-2007-1, 2007)
Start date: 2008-04-01
End date: 2010-03-31
Duration (months): 24.0
Total project cost (EUR): 1463125.2
EU funding (EUR): 990797.5
Participants: 9
Project status: CLOSED

The goal of the SFERA project is to deliver a complete innovative solution by developing a new Subsurface, Fast internal Engraving and Reading system suitable for Anticounterfeiting applications needed by the pharmaceutical industry. Counterfeiting is a major global problem, with important societal and economic consequences, including the expansion of organised crime, loss of jobs and tax revenues, as well as serious health and safety risks, for which the pharmaceutical sector is particularly vulnerable. Thanks to a successful project supported by the European Commission “Naginels” (COOP 512931), an innovative process allowing to engrave inside of the transparent materials without any damages for the material has been developed. Direct engraving of the products with this technology linked with diffractive designs, coding and vision systems provides a full Track and Trace solution. The current process speed is well suited to luxury applications, but does not yet meet the requirement of the pharmaceutical industry. No suitable on-line high speed reader is available today for the invisible engraved codes. Unfortunately, it is not possible to improve the current technologies used by Naginels. Main technology breakthroughs have to be made. No other technology than Naginels is suitable for such anticounterfeiting applications for pharmaceutical industries. Developing and validating a new technology and system as defined in SFERA project will led to a direct answer for an urgent request of this industry, as shown by all the letters of interest received from the main players in this field. In addition, the new process speeds will open new glass applications, as innovative decoration. The SFERA project will benefit from an experienced, market oriented industrial consortium to make the necessary technology breakthroughs for the laser and for the beam system. The targeted very high rates will also imply innovations on process/control, mechanical handling and vision.

Keywords: anticounterfeiting,pharmaceutical,engraving,encryption
Korea-EU Science and Technology Cooperation Advancement Programme (KESTCAP)

Framework: FP7 — Capacities
Programme: Activities of International Cooperation
Destination: Bilateral coordination for the enhancement and development of S&T Partnerships
Action type: Coordination and support actions
Countries involved: Korea, Republic of,Germany
Call:  (FP7-INCO-2007-2, 2007)
Start date: 2008-07-15
End date: 2012-01-14
Duration (months): 42.0
Total project cost (EUR): 1022912.0
EU funding (EUR): 465000.0
Participants: 3
Project status: CLOSED

KESTCAP, Korea EU Science and Technology Cooperation Advancement Programme, is based on the Science and Technology agreement signed between Korea and the EU, Nov 2006 and seeks to; provide a platform to strengthen the S&amp;T agreement between Korea and the EU; improve this cooperation by identifying S&amp;T fields of common interests of Korea and the EU; set up a website and information help desks to respond to specific inquiries on existing opportunities and available funding instruments; contribute to the Korea-EU policy dialogue on science, technology, and innovation. The specific objectives are to: Develop sustainable cooperation strategies; disseminate information and promote cooperation; and organise and support cooperative events between Korea and the EU. Work packages have been organized to ensure effective delivery of these objectives. They will create: a website portal to European-Korean S&amp;T collaboration; an online database of researchers involved in interdisciplinary and collaborative EU-Korean research; information/help desk services for researchers seeking collaboration opportunities; networks of researchers involved in and interested in collaboration, and fora to share information and experiences; promotion of existing collaboration and opportunities for new collaboration; bilateral research networks to promote collaboration; and thematic networks in areas of mutual priority. KESTCAP is coordinated by KICOS located in Seoul, Korea. The implementation strategy will use 3 key instruments: study, website, and fora. Events such as fora shall be organised in a &quot;top-down&quot; manner and will be complemented by &quot;bottom-up&quot; fora. The Ministry of Education, Science and Technology, MEST, shall be funding approximately half of the total budget.

Keywords: support action,korea eu science and technology agreement,forum,website,study,information dissemination,raise awareness,cooperation promotion
Independent Living for Today's Society: Understanding the Elderly and Disabled for Tomorrows Inclusive Smart Home Solution (PROMOVEO)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: United Kingdom,France,Czechia,Greece,United Kingdom,United Kingdom,Spain
Call:  (FP7-SME-2007-1, 2007)
Start date: 2008-11-01
End date: 2010-10-31
Duration (months): 24.0
Total project cost (EUR): 955308.0
EU funding (EUR): 720613.0
Participants: 11
Project status: CLOSED

With a growing trend in the uptake of advanced ICTs to assist in everyday tasks; ubiquitous computing is an integral part of the modern European society. However, those who are either incapacitated or elderly are often unable to take advantage of the opportunities offered by ICT. The dynamic nature and changing demands of the future European society is inevitably going to have socio-economic implications - with social inclusion at the forefront. Home automation is a $1.3bn industry with an estimated market value of $10bn by 2010, however the smart home market is an area with limited flexibility for the changing European society. The current solutions are expensive and require extensive expertise for operation. The market itself is fragmented, with the dominating players residing in the USA and Middle-East, as are the contributing devices/interfaces to the technology with little or no consideration for differing needs and abilities of the end-user. The Digital Smart Home Solution (DSHS) is a home automation system that will act as the ‘glue’ to integrate third-party devices compliant with the EIB/KNX communication standards. It will do so by providing a low-cost server architecture – the central intelligence unit (CIU) – comprising of a physical server (interfacing the devices), a software-based service gateway with underlying artificial intelligence capable of adapting the system to the intended user(s) and environment, and a user-friendly graphical user interface (GUI). Current limitations lie within ascertaining the system requirements of the disabled and elderly for such as system, as well as allowing the retro-fitting of third-party devices to become compliant with the DSHS. Furthermore, specific user-system interaction will need to be further investigated to provide ultimate user convenience.

Keywords: eib,artificial intelligence,hardware integration
Methodology for fast and reliable Investigation and Characterization of Contaminated Sites (MICCS)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: United Kingdom,Netherlands,Denmark,Italy,Germany,Denmark,Netherlands,Lithuania,Lithuania,United Kingdom
Call:  (FP7-SME-2007-1, 2007)
Start date: 2008-11-01
End date: 2011-04-30
Duration (months): 30.0
Total project cost (EUR): 1801336.25
EU funding (EUR): 1280207.0
Participants: 11
Project status: CLOSED

There is an increasing understanding that our natural resources should be kept unspoiled, which makes polluted soil and groundwater not acceptable. Therefore, a lot of resources are used for investigating contaminated sites, limiting the damage from pollution and cleaning polluted soil and groundwater. The site investigations are very costly and time consuming. They are normally based on traditional methods where vertical drillings through the soil matrix are used for soil and groundwater sampling and testing for pollution and characterising the geology. A recent development is the use of probes driven down into the soil. The probes can be used for taking out samples of soil, water or air, or direct physical /geotechnical investigation. The sampling method is faster than drilling and can be combined with analytical equipment on the surface, hereby doing online measurements for volatile compounds. The overall aim of the MICCS project is to develop a more advanced in-situ investigation method for identifying and characterising pollution. This will be achieved by integrating more sophisticated sensors (e.g. micro-chips, electrochemical sensors, spectrometry, and optical sensors) into a solid probe intended to drive down through the soil matrix to perform continuous or semi-continuous measurements. The sensor measurements are combined with improved soil radar solutions (GPR) for better positioning and soil structure specification. The combined data are processed in a chemometric system, being able to draw a more precise picture of the contaminated site as a whole. Together, the sensor measurements provide improved and more precise data input through the chemometric analysis as basis for better decision making. Furthermore, the investigation method will be easier and quicker to use, and hence also less costly than current SOA investigation methods.

Keywords: chemometry,sensors,gpr (ground penetration radar)
Elimination of secondary surgery for removal of internal fixations of fractured bones (FRACFIX)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: France,Germany,Norway,United Kingdom,United Kingdom,United Kingdom,Czechia
Call:  (FP7-SME-2007-1, 2007)
Start date: 2008-11-01
End date: 2011-07-31
Duration (months): 33.0
Total project cost (EUR): 1442861.53
EU funding (EUR): 1127808.0
Participants: 9
Project status: CLOSED

Internal fixation components are widely used in fracture surgery. The medical implant industry is a part of the medical device market generates about €2.4 Bn in Europe and €1.5 Bn in the USA in 2008 and has an estimated annual growth of 10% per year, largely attributed to the aging population in the developed countries. Internal fixation devices market is an estimated €980 Mn in EU25. The total cost of treatment is much higher due the cost of removing the fixation devices, an estimated €3.4 Bn per year in EU25. The idea of FracFix is to develop a fixation system that can be painlessly and easily removed at exact desired moment without surgery and general anaesthesia. During the project a fixator in nano-polymer composite with melting temperature below 50ºC and solid at 41.5 ºC, will be developed to use as the construction material for standard internal fixation parts, as well as an external unit able to melt the material so it can be removed through a 10mm hole in the skin. Internal fixation hardware removal results in high costs for the hospitals and risks and discomfort for the patrient. Removing the need for secondary surgery gives saving of medical personnel’s time and average cost of use of recovery room after general anaesthesia is €400 per patient, bringing the total bill of surgery to €1,250 per surgery. The data for combined surgery and trauma suggests that 18.1% of all procedures in the group result in major complications, and 13.5% result in minor complications, adding to morbidity costs to society. At 140,000 internal fixation removal procedures per year in EU and 90,000 in the USA, the estimated yearly death toll due to hardware removal only is 3,192 patients per year in EU25.

Keywords: composite technology,nano technology,inductive heating,medical implant technology
New E-Services for a dietary approach to the elderly (RISTOMED)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: Italy,Germany,France,France,France,Portugal
Call:  (FP7-SME-2007-1, 2007)
Start date: 2008-11-01
End date: 2011-04-30
Duration (months): 30.0
Total project cost (EUR): 1306250.0
EU funding (EUR): 969406.0
Participants: 8
Project status: CLOSED

Most nutraceutical SMEs have a limited access to the information needed for identifying the impact of their product at nutritional level. Also, the need of more personalized diets is an urgent requirement of EU healthcare systems,particularly for ageing and elderly people(EP).Nutraceuticals have different constraints not homogeneously defined in the EU Member States(MS)and their efficacy is always subordinate to the quality of the usual diet in different cultural scenarios.As a result,nutraceuticals are difficult to customize upon the needs of a specific market user, such as the EP, and their market is quite slow and fragmented. In response to these challenges,the goal of RISTOMED is to develop a new e-Health service for EP that will enable participant SMEs to penetrate the EP consumers market with the production of an innovative diet model. Biotech nutraceuticals,specifically designed and efficaciously delivered to the EP, will be integrated in biotech/ICT strategies coping with the complexity of nutritional specific requirements. RISTOMED brings together 8 partners distributed in 5 countries with a good balance between SMEs and RTDPs.In RISTOMED 3 biotech SMEs will collaborate with 4 RTDPs to solve the common problem of delivering innovative nutraceuticals for the control and prevention of the age-related diseases throughout new E-Health services.These services consist in the delivery of recipes and procedures containing nutraceuticals and probiotics specifically designed for EP and institutions dealing with EP throughout a new IT RISTOMED web platform(RWP).RWP will be developed by the ICT SME leading the consortium. The project result is expected to have a significant impact on the competitiveness of SME participants that will be able to expand their business by proposing to the market not only nutraceuticals but an integrated solution to better manage the diet and nutritional needs of EP to contrast inflammation,oxidative stress and gut microbiota alteration.

Keywords: inflammageing,oxidative stress,gut microbiota
High Energy Digital Radiography (HEDRAD)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: United Kingdom,United Kingdom,Greece,Germany,Bulgaria,Germany,Germany
Call:  (FP7-SME-2007-1, 2007)
Start date: 2008-10-01
End date: 2011-01-31
Duration (months): 28.0
Total project cost (EUR): 1499999.8
EU funding (EUR): 1106600.0
Participants: 8
Project status: CLOSED

The project objective is to develop digital computed radiography technology for the volumetric examination of large scale safety critical pressure components (e.g. pump bowls, valve bodies, thick section vessel and pipe welds) for the detection of in-service defects, the presence of which could lead in catastrophic component failure. Energy sector businesses (e.g. oil &amp;amp; gas, petrochemical and power generation - civil nuclear and fossil fuel) use processes that operate at high pressure and often high temperature. The engineering components used in such processes include for example, pipes, valves, turbine casings, pump bowls, catalytic crackers/reformers etc, all of which can be made of large section thick materials to withstand the severe pressure/temperature conditions under which they operate. All of these components can be prone to in-service failure resulting from material degradation mechanisms such as metal fatigue, creep and corrosion. Failure of such components could easily be catastrophic in terms of local and district fatalities/injuries and environmental /economic impact. There are approximately 700 refineries, 5000+ chemical plants, 450 nuclear power stations and in excess of 3000 fossil fuelled power stations around the world. The trend is for the number of these plants to increase as the worlds developing countries will consumes ever increasing amounts of energy. Capital assets such as power stations, refineries and petrochemical plants usually generate revenues of typically €1 million/day. However, despite their strategic and critical applications and the dire ‘consequences of component failure’ (local and district safety hazard, environmental and economic), there are generally no economic, reliable Non-Destructive Testing (NDT) techniques to volumetrically in-service examine critical thick section pressure retaining components that are vital to the plants continued safe operation.

Keywords: digital computed radiography,safety critical pressure components - oil & gas,power generation