Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Character Matters: Individual Character, Moral and Political Education in Victorian Britain (CHARMA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

This project (CHARMA) is a study of the political importance of the concept of personal character in Victorian England. CHARMA will be developed through a 24-month European Fellowship with the University of Manchester. The overarching goal of this project is understanding the relationship between the cultivation of individual character and the plans for building a peaceful society, at a time when Britain was experiencing rapid socio-economic and political change. To achieve this overarching goal, I divided my project into two sub-goals. My first sub-goal is understanding the Victorian discourse of character and its political importance through texts of early and mid-Victorian political thought. This study will be pursued by textual analysis. My second sub-goal is demonstrating that this concept influenced actual plans for educational and social reform. To do so, I will focus on a case-study: I will analyse the reform practices and institutions of a highly influential group of Dissenters, the Unitarians, in Victorian Manchester. This study will be pursued through archival research, using the vast collections in the University of Manchester Archive. I will also used social network analysis to trace the connections of Unitarians with different social groups and represent them graphically. This project will contribute to the fields of intellectual history, history of political thought and political philosophy. CHARMA's methodology is interdisciplinary, as it combines different fields, different kind of sources and a practice-based, bottom-up approach with a contextualist study of published texts. CHARMA also uses a mixed-methods approach and provides methodological innovation by introducing a new method, social network analysis, into the field of intellectual history.

Keywords: history of the idea of character victorian age social reform unitarianism
FluorineID: Bridging identity and quantity – Unraveling the unknown fluorine content in environmental samples via quantitative non-target screening (qNTS) (FluorineID)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark,Sweden,Luxembourg
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 247553.28
EU funding (EUR): 247553.28
Participants: 3
Project status: SIGNED

Per- and polyfluoroalkyl substances (PFAS) encompass potentially millions of synthetic compounds that are widely used in modern society. These “forever chemicals” are extremely persistent, harmful to health, and are widespread globally. Despite advancements in their analysis, high levels of unknown fluorine—termed “PFAS dark matter”—persist in the environment, indicating that most fluorinated compounds remain unidentified. "PFAS dark matter" can originate not only from PFAS but also from many other emerging fluorinated compounds, including ionic liquids. Cutting-edge non-target screening (NTS) with high-resolution mass spectrometry (HRMS) can detect thousands of chemicals like PFAS but is typically only qualitative and limited in scope. FluorineID aims to address this gap and to unravel the “PFAS dark matter” by developing computational quantitative NTS (qNTS) methods that (1) integrate key chromatographic separation platforms for broader chemical space coverage, (2) prioritize the millions of fluorinated compounds in the online database PubChem for efficient and comprehensive identification, and (3) apply machine learning to quantify fluorinated compounds. The combination of individually identified and quantified fluorinated compounds with total fluorine measurements will allow verification via fluorine mass balance approaches. FluorineID will advance the identification and quantification of unknown fluorinated compounds, support identifying the origin of unknown fluorine in the environment, and offer open source qNTS workflows to accelerate future community-wide identification and risk assessment of “PFAS dark matter”.

Keywords: quantitative non target screening qnts,high resolution mass spectrometry hrms,per and polyfluoroalkyl substances pfas,fluorinated compounds,fluorine mass balance
Beyond the Protein: Manipulating Proteoforms with Chemical Tools (PROTEOFORMER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Czechia
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-04-01
End date: 2031-03-31
Duration (months): 60.0
Total project cost (EUR): 1810000.0
EU funding (EUR): 1810000.0
Participants: 1
Project status: SIGNED

The human body can synthesize ~70’000 different proteins. These proteins diversify into millions of proteoforms, e.g., by associating into complexes or acquiring functionalities called post-translational modifications (PTMs). Distinct proteoforms are often found in different cell types and have diverse functions. Dysregulation of specific proteoforms is associated with many diseases, including neurodegeneration or cancers, highlighting the need for their study and modulation. Despite these needs, most drug-like molecules are designed to indiscriminately activate, inhibit, or destroy a target protein—they are blind to the localization or function of different proteoforms. PROTEOFORMER goes beyond the protein by developing chemical tools for manipulating specific protein forms. In two parallel initiatives, PROTEOFORMER will: (1) Target a specific proteoform of the muscarinic acetylcholine receptor—relevant to Parkinson’s disease treatment—dissecting its function and laying the groundwork for new therapies. (2) Modify post-translational modifications of matrix metalloproteinase-2—a key regulator of neuroinflammation—aiming to unravel their so-far-elusive function. PROTEOFORMER offers tailored reagents that (i) recognize the protein target, (ii) bring a reactive group to the target’s surface, and (iii) attach molecular cargo to the protein via a proximity-induced reaction. It rethinks this ‘ligand-directed chemistry’ by introducing functional, proteoform-manipulating cargo: (1) A blocker of a partner protein, enabling proteoform-selective inhibition within a cell-specific complex. (2) A post-translational modification or its eraser, enabling on-demand switching between proteoforms with newly developed proximity-driven chemical reactions. PROTEOFORMER develops new chemistry for manipulating proteoforms beyond current capabilities. These general concepts represent a chemical solution to long-standing challenges in biology that are intractable with traditional methods.

Keywords: proximity driven protein labeling,post translational modifications,chemical neuroscience
Science for Evidence-based and sustainabLe decIsions about NAtural capital (SELINA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Germany,Netherlands,Malta,Italy,Bulgaria,Hungary,Lithuania,Slovenia,Greece,Luxembourg,Spain,Austria,Romania,Belgium,Latvia,Poland,France,Denmark,Norway,Estonia,Cyprus,Finland,Czechia,Slovakia,Portugal,Israel,Ireland,Sweden,Croatia,Switzerland,United Kingdom
Call: Ecosystems and their services for an evidence-based policy and decision-making (HORIZON-CL6-2021-BIODIV-01, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 12213780.0
EU funding (EUR): 12213773.0
Participants: 51
Project status: SIGNED

The importance of biodiversity (BD) and healthy ecosystems and the services they deliver has increasingly been acknowledged. Policy initiatives, such as the EU BD Strategies 2020 and 2030, IPBES, IPCC and CBD were launched to address BD, natural capital and related values. Research has created a knowledge base to better understand nature-human interactions that are at the base of ecosystem services (ES) delivery. The key aim of related actions is to provide robust information that can be harnessed to support protection, restoration and sustainable as well as climate-neutral use of ecosystems in the EU by 2030. MAES has provided the conceptual, methodological and data base for comprehensive assessments on different spatial scales, including the EU-wide assessment (2020) and assessments in EU member states. Knowledge and data for different ecosystem types (including protected and marine areas) are increasingly available. The next step is to integrate the different MAES components (ecosystem mapping, condition, ES, accounting) and to enable the uptake of ES in decision making. Key challenges include the proof of BD-ecosystem condition-ES relationships and to link them to EU policies. The consortium brings together experts from all EU member states, associated countries and EU overseas regions with stakeholders from various public and private sectors. The expertise in the consortium includes leading experts (ecologists, economists, social scientists) on ES science, ecosystem accounting and on science-policy-business interfaces from related actions (OpenNESS, ESMERALDA, MAIA, MAES, ESP, IPBES, BD Partnership). Therefore, the project will successfully address the call's challenges and provide applicable tools and models together with guidance how to use them. The project will deliver real cases for an evidence-, ES-based and harmonised decision making across Europe, enabling transformative change to halt BD decline and to secure essential ES-sustainable supply and use.

Keywords: ecosystem condition,biodiversity,ecosystem services,policy making,transdisciplinary,sustainability
Diversity Outdoors: Embodied ethnoracial inequalities and outdoor recreation in Europe (DivOut)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

This project seeks to investigate how social inequalities are embodied through a comparative analysis of participation in outdoor recreation in Europe. Outdoor recreation – such as hiking, climbing, swimming, but also birdwatching and camping – is as a pivotal arena where racialized encounters and practices manifest. Given the current international attention to diversity and (lack of) anti-racism in Europe on the one hand, and the understudied emerging grassroots outdoor movements that challenge these discourses on the other, it is essential that we better understand the embodiment of ethnoracial inequality and its intersections with religion, gender, class and ability. This project undertakes a comparative ethnographic study of ethnoracial embodiment in outdoor recreation in Western-Europe, while asking the questions: What are the effects of ethnoracial embodiment on sociocultural diversity in outdoor recreation? How are bodies constituted as in or out of place in outdoor recreation in Europe? How is diversity in outdoor recreation influenced by local, national and transnational discourses and imaginations? What is the role of ethnoracial affinity and opposition in experiences of participating in, and contesting the status quo of outdoor recreation? The central objective is to gain insight in the commonalities and socio-cultural distinctiveness of how ethnoracial inequalities are embodied, experienced, and contested across Europe. It does so by analysing the embodied, sensorial dimensions of racialization (and its intersections) in outdoor recreation and developing a theorization on ethnoracial embodiment. The concept sensory ecology helps innovatively analyse identity-based outdoor groups and activities, outdoor recreation policies and discourses between local movements, national- level organizations and online communities. The project compares three countries with emerging identity-based outdoor groups: the Netherlands, Germany and the United Kingdom

Keywords: leisure embodiment
FlagChip: Saliva-Based At-Home Diagnostic Platform for Diabetes Diagnosis (FlagChip)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 36.0
Total project cost (EUR): 2450000.0
EU funding (EUR): 2450000.0
Participants: 1
Project status: SIGNED

Labrador Sciences is creating FlagChip, a saliva-based at-home diagnostic platform for Type 2 Diabetes diagnosis. The device uses microfluidics to manipulate and control small amounts of fluids within microscale channels and structures, enabling precise handling, mixing, and analysis of saliva samples in a miniaturised and controlled environment. Afterwards, it is analysed by a computer vision algorithm on the user's smartphone that calculates the levels of equivalent blood glucose based on biomarker concentrations to provide a diagnosis. Compared to other solutions, it does not require drawing blood, going to a clinic for a confirmatory test, and other special testing methods that require going to a healthcare professional. Type 2 diabetes (T2D) is a growing pandemic that impacts more than 10% of the global population and costs hundreds of billions of Euros every year. With almost 50% of diabetics remaining undiagnosed, there is a great need for a solution that is scalable, reliable, accurate, and easy to use for every patient to reduce and prevent the onset of Type 2 Diabetes.

Keywords: microfluidics diabetes mellitus in vitro diagnostics computer vision biomarkers diabetes prevention diagnosis digital health self calibration
Restoring the structural collagen network in the regeneration of cartilage (Re-COLL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 2
Project status: SIGNED

How can we durably regenerate damaged tissues in our body? At present, the answer to this question is largely unknown. Cell-based tissue engineering approaches can be used to produce living implants in the laboratory with a composition that is not unlike real tissues. However, the collagen-based matrix within such structures often lacks the specific intricate organisation that is imperative for the required biomechanical properties, functionality and mechanical stability. This is the cause of our inability to provide a durable cure for damaged tissues that are mechanically challenged, such as articular cartilage. In Re-COLL, I aim to unravel the triggers that underlie the formation, guidance and integration of the structural anisotropic collagen networks in articular cartilage and leverage biofabrication technologies and biointerface engineering to generate durable implants for the restoration of damaged joints. With my multidisciplinary team, I will identify the (bio)chemical, physical and mechanical factors that can influence the formation and integration of the engineered collagen engineered collagen network. For this purpose, I will create unique in vitro and ex vivo models specifically designed for studying the organisation of anisotropic collagen networks in cartilage tissue. With the generated new insights, I will engineer larger tissue grafts that allow the guidance of the structural collagen organisation, as well as its integration within the recipient. To delineate the interplay between the anisotropic collagen networks and tissue function, I will extensively evaluate the performance of cartilage grafts at the tissue and organ level. Through Re-COLL, I will advance the scientific field of orthopaedic regeneration by tackling major gaps in knowledge and technology to set the fundamentals for engineering more functional and stable biosimilars that can restore tissue anisotropy in patients.

Keywords: biofabrication cartilage collagen melt electrowriting joint preservation bioprinting
Regulation of ABA production and cell wall viscoelasticity by the cell wall integrity maintenance mechanism (WallABAutStiffness)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 1
Project status: SIGNED

Recent severe heatwaves and prolonged drought negatively affect agricultural crop fitness and biomass, threatening global food security. Therefore, there is an urgent need to enhance crop resilience against environmental stress to reduce crop loss. The cell wall is of key interest here due to its role as the primary barrier against environmental stress. However, improving crop tolerance via cell wall manipulation remains challenging due to plasticity, which determines the wall's ability to alter its shape, composition, and viscoelasticity (stiffness and viscosity). Plasticity seems to be modulated by the cell wall integrity (CWI) maintenance mechanism. A mechanism that continuously monitors the functional integrity of cell walls by utilizing a wide range of CWI sensors to sense damages in the cell wall and initiate wall remodeling. Any impairment in the CWI triggers adaptive responses, including the production of phytohormones. Abscisic acid (ABA) is one of the key phytohormones that regulate plant adaptive responses against abiotic stresses. Although the potential of the CWI maintenance mechanism modulating cell wall plasticity via ABA signaling has been proposed, the underlying mechanism remains largely unexplored. Therefore, investigating interactions between these processes may lead to the development of novel strategies to improve plant tolerance against abiotic stress. In this project, I will investigate the relationship between changes in ABA and cell wall viscoelasticity controlled by the CWI maintenance mechanism. I will also identify and characterize novel components of the CWI maintenance mechanism responsible for the induction of ABA production. Furthermore, the knowledge produced here will facilitate the identification of corresponding orthologs in commercial crops that can be used to develop strategies to improve crop performance.

Keywords: cell wall integrity,cell wall stiffness,viscoelasticity,abiotic stress,osmotic stress,brillouin microscope,flim fret,biosensors,abscisic acid,arabidopsis,adaptation
A universal spectral imaging sensor platform for industry, agriculture and autonomous driving (HyperImage)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Innovation actions
Partnership: Photonics (co-programmed)
Countries involved: Germany,Netherlands,Norway,France,Czechia,Switzerland,Luxembourg,Spain
Call: Advanced imaging and sensing technologies (IA)(Photonics Partnership) (HORIZON-CL4-2023-DIGITAL-EMERGING-01, 2023)
Start date: 2023-12-01
End date: 2027-05-31
Duration (months): 42.0
Total project cost (EUR): 7055111.66
EU funding (EUR): 5558854.47
Participants: 13
Project status: SIGNED

The HyperImage project will be the first initiative to develop a universal, fast, modular and cost-effective spectral image sensing technology platform suitable for both short- and long-range imaging applications. To achieve that, HyperImage will make use of innovative photonic components including electrically tunable liquid lenses, pixel shifters, fast steering mirrors, and configurable SMD style IR micro-emitter arrays. HyperImage will integrate these components into innovative, high-performance multi- and hyperspectral snapshot and line scan cameras. AI machine learning algorithms will translate spectral image data into relevant functional products properties and detect and classify objects for more accurate decision making e.g. in autonomous driving. The technology platform will be complemented with a cloud-based spectral image analysis platform and reference data repository that enables users to continuously improve image analysis accuracy and prediction models. The HyperImage technology platform will be validated in four industrial use cases: (1) quality control in manufacturing of high power electronics; (2) crop growth monitoring for fully automated vertical farming of salads, herbs and microgreens; (3) spectral image based vision and navigation in off-road autonomous driving; (4) light-weight, high-resolution hyperspectral vision system for unmanned geo-surveillance drones. Based on that, HyperImage will provide European Industry a universal, efficient and reliable solution for object recognition, detailed product and material analysis and reliable quality control in manufacturing. HyperImage solution will lead to strong benefits for the applications such as 10-20% increase yield and reduced cost in manufacturing and vertical farming, 20% fuel saving and up to 40% increased operation speed in autonomous offroad driving; and up to 10% drone weight reduction (25 kg MTOW class) yielding 50% increased flight time through space for a larger battery.

Keywords: spectral imaging,sensors,image processing,optics,