Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mind the Gap: from Plasma Kinetics to Cosmological Galaxy Formation (PICOGAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

In the modern picture of galaxy formation, baryonic feedback is critical for shaping galaxies and regulating star formation. On small scales, feedback results from transporting momentum, radiation, thermal and relativistic particles but current-day magneto-hydrodynamic simulations of galaxies and galaxy clusters often neglect or over-simplify these transport processes. Electrons transport heat and cosmic rays exchange momentum and energy with the thermal plasma but both species are erroneously assumed to diffuse along magnetic field lines. However, this is in conflict with the latest plasma simulations and observations in the solar wind and of the galactic center, which imply efficient wave-particle scatterings so that the electrons and cosmic rays are advected with whistler and Alfvén waves, respectively. We propose a coordinated multi-scale approach that combines plasma kinetic and global fluid models of particle acceleration and transport in galaxies and galaxy clusters with unprecedented accuracy. In particular, we will run novel plasma simulations of shocks at supernovae and galaxy clusters, and study the plasma-wave mediated transport of electrons and cosmic rays. We will employ information field theory to coarse grain these models to derive effective transport coefficients, which will be implemented in macroscopic fluid models of cosmic ray transport and thermal conduction. Simulating feedback by cosmic rays, radiation and supernovae in cosmologically forming galaxies on scales from dwarfs to our Milky Way provides transformative changes of the physics accuracy of these models. This is complemented by cosmological galaxy cluster simulations with improved physics to understand the origin of the cluster-core bimodality, giant radio relics and halos. Comparing mock multi-frequency observables from radio to gamma-rays to data enables falsification or validation of the underlying plasma models and represents a major step towards predictive galaxy formation.

Keywords: plasma astrophysics,computational astrophysics
Fibersail: Shaping the Structures of Tomorrow (Fibersail)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Portugal
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-05-01
End date: 2017-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Fibersail system is an output of R&D efforts, it consists on a shape sensing system based on FBG fiber optic to monitor and analyze windmill blades in terms of shape, condition and behavior. The real-time information provided will help wind turbine operators to maximize performance and availability, while preventing failures and maintenance costs from their windmills. Large multinationals are now making huge investments in wind power parks renovation. Critical structures need to be regularly inspected and maintained, which increases OPEX costs, and even so, accidents occur, because condition monitoring systems are not effective. There isn’t a way to monitor the shape behavior of a structure to precisely understand its condition. STME R&D a shape sensing system based on fiber optic sensing and powered by machine learning tools to measure and monitor the shape and behavior of critical structures, like wind turbine blades, to increase availability, improve efficiency, prevent failures, reduce maintenance costs and extend the lifetime. This innovation regards to a system able to easily be applied, removed or re applied again to measure the shape of structures in a continuous way, while predicting the future behavior based on machine learning tools, so that maintenance can be adapted to the real need, and that the new knowledge of structure behavior in real environment can help design more efficient ones. This system will also prevent critical failures from happening and therefore accidents. The number of wind turbines will increase for the next years, expecting 35000 in 2018, 315.000 in 2020 and 1 Million in 2022, including other critical structures, like piles, cranes, ships and airplanes The company expects to get the Break Even in 2019, and ROI in 2020, including Revenues of 22.500.000€, Profit of 5.750.000€ and employing 24 persons.

Keywords: first shape sensing system based on fbg fiber optic provided with a big data platform and machine,learning tools to monitor and analyze windmill blades in terms of shape,condition and behavior
PROducing Stem Cells for improved Treatment of patients (PRO-SCT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The market for stem cells is growing fast as new possibilities for stem cell treatments evolve. Today stem cell treatments are often based on a process where the patient’s own cells are grown for weeks, and thereafter patients are treated with their own stem cells. This process limits a wider use of these treatments, as it is a slow and costly procedure. The key novelty in the PRO-SCT project is that it is the first fully compliant industrially applicable platform capable of large-scale stem cell production from healthy donor adipose tissue, making ready-to-use stem cells available whenever and wherever needed. Cell2Cure has leading competencies in the areas of producing, storing, and distributing stem cells from donors, and clinical and regulatory know-how in the use of cell-based therapies. C2C stem cells will be manufactured in large batches, stored frozen in vials that can be ready for use in a few minutes before treatment. The C2C technology uses state-of-the-art automated closed bioreactor systems with animal component free expansion of allogeneic cells and long-term cryopreservation of ready-to-use vials. Compared to today's stem cell treatment, this allows for scalability and easy distribution - improving availability and reducing both cost and time to treatment. With a strong scientific basis, Cell2Cure has made significant progress in the understanding of donor derived stem cells in the development of treatments for heart failure. Clinical trials have shown that C2C stem cells are safe, usable and have promising clinical effects. The aim of the PRO-SCT project is to develop a strong commercial and operational position for Cell2Cure to move from small scale to large scale capacity and unlock a new global market for adipose tissue derived donor stem cells. To do this successfully, the support of EU-Instrument phase I will be of immense importance. Cell2Cure has firm control of the intellectual property with a broadly covering WO-patent application in place.

Keywords: production,handling,and distribution of stem cells,allogenic donor cells,treatment of heart disease,industrially applicable gmp production technology,clinical phase i,shows safety and effect
Hybrid DNA-protein nanopores with large and uniform pore sizes (HYBRIPORE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

This proposal aims at developing novel hybrid DNA-protein nanopores with well-defined, uniform channel sizes, to advance fundamental studies on transport across membranes and to enable the development of new biosensors and progress towards creating artificial cells and tissues. Currently used protein nanopores either have a limited cargo capacity, which is set by their internal diameter, or they are heterogeneous in size and sometimes incompletely assembled. I propose to use DNA origami nanostructures as scaffolds for barrel- and ring-forming peptides of alpha-haemolysin and ClyA/Wza to create hybrid pores with larger and uniform pore sizes. These hybrid pores have the advantage that they are fully biocompatible and retain the potential for genetic and chemical engineering at the level of the DNA and proteins through the use of nucleotide recognition sequences and functionalised amino acid residues. By systematic characterisation of the hybrid nanopores in the controlled environment of droplet interface bilayers using single-channel current recordings and fluorescent detection of transport across membranes, the proposed hybrid nanopores will provide valuable insights into membrane transport and potential applications in biotechnology and medicine.

Keywords: nanopores,alpha haemolysin,protein engineering,dna origami,membrane transport,biosensors
Microbiome-based stratification of individuals at risk of HIV-1 acquisition, chronic clinical complications,antimicrobial drug resistance,and unresponsiveness to therapeutic HIV-1 vaccination (MISTRAL)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Spain,Sweden,France,United States,Denmark
Call: Stratified host-directed approaches to improve prevention, treatment and/or cure of infectious diseases (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2025-06-30
Duration (months): 66.0
Total project cost (EUR): 9994383.75
EU funding (EUR): 9994383.75
Participants: 16
Project status: SIGNED

The HIV/AIDS pandemic continues to be one of the major health challenges ever faced by mankind. Far from being resolved, HIV is soaring in Eastern Europe (60% increase in new infections and 27% increase in deaths since 2010) and other regions of the world despite increasing access to antiretroviral treatment. There is emerging evidence that the human microbiome impacts some of the most important clinical aspects of HIV-1 infection, including immune disorders, chronic inflammation and accelerated aging. Work in other viral diseases and cancer immunotherapy suggest a critical role of the human microbiome also in the outcome of immune therapeutic interventions in HIV-1 infection. The MISTRAL project brings together a team of world-class HIV and microbiome researchers and SMEs with ideal complementary knowledge and expertise. This team will work to discover and validate novel gut microbiome biomarkers to inform rationally-designed, mechanistically-driven interventions on the gut microbiome to mitigate HIV-1 acquisition, systemic inflammation, chronic clinical complications, antimicrobial drug resistance, and boost the efficacy of HIV cure immunotherapies. Integrated and curated large microbiome and host datasets generated during the execution of the project will be made public through a freely accessible, specifically-dedicated web-based repository. Biomarker discoveries will be incorporated into a cloud-based software tool that will automate microbiome analyses and interpretations, thus streamlining patient stratification for clinical and research purposes. If successful, MISTRAL will benefit millions of human beings living with, or at risk of acquiring HIV-1 infection, and will produce novel concepts and technical innovations applicable to other human diseases. By doing that, MISTRAL will help to unlock the full clinical potential of the human microbiome to stratify patient outcomes and will irreversibly bring microbiome science closer to clinical practice.

Keywords: gut microbiome,hiv 1infection,inflammation,vaccination,biomarkers,inflammaging,immunity,systems,biology,bioinformatics
Revolutionary Nanodrip printing technology for industrial scale manufacturing enabling the next generation of high-end devices Type of funding scheme: SME Instrument (NanoDrip)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-01
End date: 2020-02-29
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The ongoing global trend of miniaturization is driven by the demand for a huge range of high-end devices such as smartphones, automotive connectivity and IoT/AI applications. This is highly dependent on the fabrication of embedded Integrated Circuits on semiconductor wafers & the advanced semiconductor packaging processes that protect ICs while providing connectivity to printed circuit boards & adjacent ICs. The fabrication of redistribution layers (RDL), is particularly challenging and expensive, representing a major challenge in the industry. Current RDL microfabrication technology constitutes multi-process chain (19 steps) and is incredibly capital intensive. Existing technology impacts the environment through vast consumption of energy and water. It provides limited flexibility at the wafer-level, restricting the use of optimised materials to microfabricate and limiting manufacturers ability to produce different packaging designs between production cycle, incurring high-fixed costs or expensive downtimes. NanoDrip is the first printing technology which is applicable to advanced packaging, providing ultra-high-resolution microfabrication suitable for industrial manufacturing in merely 2 step-process. It enables digitality, the capability to produced different designs between production cycles with unprecedented flexibility. It introduces a disruptive paradigm shift in the fabrication of advanced electronics at a crucial time for the European industry, allowing European SMEs & large semiconductor manufacturers to gain competitive advantage as demand grows for next-generation of devices. During the phase 1 project, Scrona will establish a go-to-market strategy and a supply chain and will draft further development plan. During the innovation project, Scrona will optimise their proprietary printheads and printing process, optimize in-house printhead manufacturing process, and carry out large-scale demonstration of microfabrication with relevant stakeholders.

Keywords: advanced packaging,wafer,industrial manufacturing,microfabrication,printing technology
Agroforestry Innovation Networks (AFINET) (AFINET)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive agri-food sector for a safe and healthy diet
Action type: Coordination and support actions
Countries involved: Spain,Italy,Belgium,Belgium,Finland,Hungary,Poland,France,Portugal,United Kingdom,United Kingdom
Call: Thematic Networks compiling knowledge ready for practice (H2020-RUR-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 1999987.5
EU funding (EUR): 1999987.5
Participants: 13
Project status: CLOSED

Agroforestry (AF) is the practice of deliberately integrating woody vegetation (trees or shrubs) with crop and/or animal systems to benefit from the resulting ecological and economic interactions. Research activities developed by AFINET partners indicates that appropriate application of AF principles and practices is a key avenue to help the European Union to achieve more sustainable methods of food and fibre production, producing both profits for farmers and environmental benefits. However up to now exists a lack of AF knowledge among end-users that prevent the correct implementation of these practices. In this sense AFINET will act at EU level in order to take up research results into agricultural practice, improving knowledge exchange between scientists and practitioners on AF activities, with a special focus on silvoarable and silvopastoral systems design, management, and production and profitability. To achieve this objective AFINET consortium proposes an innovative methodology based on: (i) The creation of a EU reservoir of scientific and practical knowledge of AF with an end-user-friendly access (the “Knowledge Cloud”). (ii) The creation of a European Interregional network (composed of “Regional Agroforestry Innovation Networks” - RAINs) considering a multi-actor approach (including farmers, policy makers, advisory services, extension services, etc.), and articulated through the figure of the “Innovation Broker”. These RAINs groups will be interconnected in nine strategic regions of Europe from Spain, UK, Belgium, Portugal, Italy, Hungary, Poland, France and Finland, representing different climatic, geographical, social, and cultural conditions at European level. In addition, to create a greater user acceptance of the collected solutions and an intensive dissemination to end-users, AFINET will be linked to other networks, initiatives and policy instruments at regional, national and European level with a specific focus on the EIP-AGRI implementation.

Keywords: agroforestry,innovation broker,eip agri,multi actor approach,participatory innovation,knowledge cloud
Probing the Memory of Earth Anoxia: New Stable Isotope Constraints on the Rise of Oxygen (ANOXIA-MEM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Atmospheric anoxia prevailed throughout the majority of Earth history, making oxygen and the animal life it supports relative newcomers to our planet. O2 accumulated in Earth’s atmosphere during two dramatic oxygenation events at ~2400 and ~600 million years ago (Ma). Both of these events were accompanied by profound biological and geochemical revolution, including the origin of animal life, making them amongst the most important events the Earth system has ever witnessed. Because the composition of Earth’s ancient atmosphere cannot be measured directly, its history must be examined using models constrained by geochemical proxies. The disappearance of sulfur isotope mass-independent fractionation (S-MIF) from the sedimentary record ca. 2320 Ma is considered the “smoking gun” evidence for the permanent oxygenation of Earth’s atmosphere. However, it was recently suggested that weathering of older S-MIF bearing sediments resulted in a prolonged S-MIF “memory effect” that lasted ~200 Ma or more, thus obscuring the true history of atmospheric oxygenation. Here I propose new hypotheses to test, for the first time, the importance of the S-MIF memory effect at the onset of atmospheric oxygenation. I will evaluate specific sulfur, strontium, and oxygen isotope signals from exciting new samples obtained through a recent French drilling program to help resolve this fundamental problem in Earth system evolution. As an American Experienced Researcher, this Marie Curie project, ANOXIA-MEM, is designed to harmonize my unique isotope geochemistry skills with the knowledge, resources, and training capacity of two renowned French isotope laboratories for the maximum benefit of all parties. This project promises new tools and analyses that are uniquely poised to upset the prevailing paradigm for Earth’s atmospheric oxygenation.

Keywords: great oxidation event,multiple sulfur isotopes,multiple oxygen isotopes,stable isotope geochemistry
Sustainable farming of European catfish (Silurus glanis) for innovative, resource efficient and eco-friendly pond farm production (SILGEN)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Hungary
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Today over 70% of world fish stocks are fully exploited or are already overfished. It is a trend since 1990s that capture fisheries production is stagnating, while aquaculture production is expanding. A European citizen consumes 17.56 kg seafood and freshwater products of untraceable origin yearly in the EU, while 57% of the total consumption is imported mainly from China and Southeast-Asia. There is a growing demand for fish products which can only be filled by aquaculture products while health and environmental concerns are raised due to aquaculture products originating from heavily contaminated geographical areas containing mercury, PCBs and other harmful substances. Sustainable aquaculture - fish farming - is needed to provide fresh, high-quality, local supply of healthy products which follows strict rules to protect the consumer, the fish and the environment. Fresh water fish comes in second after seafood products, however in the landlocked countries of Europe (Hungary, Czech Republic, Slovakia, etc.) freshwater fish consumption is traditional and pro vides a stable market which will stay so until 2030 according to recent statistics. Although common carp, as the traditional product of Central and Eastern European fish farmers, has a stagnating market with very low potential for growth. Our company, Aranyponty Halászati Zrt. is one of the biggest freshwater producers in Central Europe and we are one of the first private companies in operation since 1989. We have full-scale fish farm system of over 1500 hectares at Retimajor, operating a high standard fish hatchery and a number of wintering ponds. Our quality assurance system grants high-quality, local product traceable from egg to plate.

Keywords: aquaculture,european catfish,pond farming