Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MPS NOVA Hub: Advanced Microphysiological Systems and Pluripotent Stem Cell Technologies to Unveil Chronic Disease Mechanisms and Host-Microbe Interactions (MPS_NOVA)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Life Sciences
Countries involved: Portugal,Germany,Italy
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 1498898.13
EU funding (EUR): 1498898.13
Participants: 4
Project status: SIGNED

Mitigating the current rise in chronic diseases and effectively addressing the enduring challenges posed by infectious diseases are pressing concerns in 21st-century healthcare. These challenges demand innovative research approaches, and microphysiological systems (MPS) have emerged as promising tools for the study of these conditions, as they are capable of replicating near-native human physiology, with significant potential for precision medicine. However, the adoption of MPS technology in Portugal lags behind, primarily due to the high expertise required. To bridge this gap, we will establish a European collaborative network, MPS_NOVA, under the coordination of the University Nova of Lisbon (UNL). This will bring together leading European institutions specializing in MPS and stem cell research, including UKJ (Germany), MDC-BIMSB (Germany), and FHT (Italy). These will collectively offer a broad range of expertise and approaches in the field of MPS and stem cell methodologies, which will fortify UNL's existing multidisciplinary knowledge and expertise, foster best practices in research and training, and expand collaborative networks. By doing so, it will enhance the capabilities, excellence, visibility, and reputation of UNL's research, researchers, and research management staff. For this, a variety of network and research activities have been devised, focusing on the integration of these cutting-edge technologies at UNL, by facilitating collaborative projects and promoting knowledge exchange among partners. Key to these achievements is the upskilling of ITQB NOVA and NMS research managers, who will benefit from tailored partner training in HR excellence, effective management strategies and optimized communication. Together, MPS_NOVA will create a European Center of Excellence in MPS and stem cell research in Portugal, driving breakthrough advances in chronic diseases and host-microbe interactions, benefiting basic and applied research, and society at large.

Keywords: microphysiological systems,organ on chip,chronic diseases,infection biology,symbiosis biology
TWINNING FOR A EUROPEAN CONSORTIUM OF RECTAL CANCER RESEARCH INSTITUTIONS THROUGH STEPPING UP SCIENTIFIC, TECHNOLOGICAL AND INNOVATION EXCELLENCE OF IORS (STEPUPIORS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Serbia,Greece,Spain,Netherlands
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 6
Project status: SIGNED

Neoadjuvant chemoradiotherapy (CRT) is the gold standard in locally advanced rectal cancer (LARC), but the response is not uniform among patients and improvements are currently being assessed. Profiling the response to CRT in patients with LARC would enable more adequate selection of patients who would benefit most from CRT while minimizing adverse effects and toxicity. Patients with a favorable response to CRT might be candidates for a less invasive surgical approach or for enrollment in a "watch and wait" approach in the case of a complete clinical response (cCR). This would increase their quality of life and contribute to the overall reduction of treatment cost. Identification of novel therapeutic targets might also benefit rectal cancer patients who do not respond well to neoadjuvant CRT. The main aim of the STEPUPIORS project is to establish a European consortium of research institutions dedicated to defining prognostic biomarkers in rectal cancer. Specific project objectives that would enable addressing this unmet clinical need are: Objective 1: Determine the molecular profile of response to neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer through a newly formed rectal cancer consortium with complementary expertise Objective 2: Strengthen the research, management and administrative abilities of the Institute for Oncology and Radiology of Serbia (IORS) located in Belgrade, Serbia along with the establishment of a rectal cancer biobank Objective 3: Establish a long-lasting knowledge, personnel, and sample exchange between participating institutions in the rectal cancer consortium. The STEPUPIORS project aligns with Europe’s beating cancer plan and the Horizon Europe strategic plan 2021-2024 within the health cluster, through setting up a research consortium that will enable improvement of rectal cancer prognosis, monitoring and treatment and lead to better health outcomes.

Keywords: rectal cancer,chemoradiotherapy,biobank
Building resilience against mental illness during endocrine-sensitive life stages (RE-MEND-Hop on)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Sweden,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 36.0
Total project cost (EUR): 466265.0
EU funding (EUR): 466265.0
Participants: 2
Project status: SIGNED

Lipids are involved in a variety of biological functions to maintain vital cellular processes at various levels in the brain. The involvement of deregulated metabolism of lipids and the formation of oxidized lipid species (epilipids) in many mental disorders underscores the importance of lipids in maintaining normal cell signalling and tissue physiology. RE-MEND-Hop on aims to pave the way on how the lipid abnormalities can contribute to the complexity of the biological criteria accounting for the individual’s susceptibility to mental illness, focusing on three population-based longitudinal cohort studies of anxiety and depression-related disorders, across four critical life stages. RE-MEND-Hop on will implement and develop (Epi)Lipidomic-based analytical methods in synergic fashion by integration with other Omics-data using advanced biostatistics, machine learning and AI, which will allow the project partners to establish a thorough understanding of the molecular pathophysiological mechanisms of mental illness. This will provide great support for identification of validated biomarker for assessing mental health state, disease predisposition, early and accurate diagnoses, disease monitoring as well as for novel drug target discovery. In addition, RE-MEND-Hop on aims guarantee the uptake of its outcomes by the scientific community as well as stakeholders, policy makers and citizens to significantly increased mental health literacy and the societal impacts. This is achieved through the communication, dissemination and exploitation of the research outputs The RE-MEND-Hop on is implemented by a strong consortium that spans the relevant layers of biological information and is seeking to lay the groundwork to better address the spectrum of mental health for personalized preventive and therapeutic measures.

Keywords: lipidomics,epilipidomics,blood microsampling,mental disorders,lipid biomarkers
Structure preserving limited area weather modelling (GeometricLAMs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Norway,United Kingdom
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 2
Project status: SIGNED

As the climate crisis progresses, and we see an increase in extreme temperatures, the importance of accuracy in regional weather forecasting significantly increases. These regional models, or limited area models (LAMs), run at the highest feasible resolution to well resolve fine grain features in the model. Due to the global nature of the atmosphere, LAMs are coupled to a global forecast model, which due to the larger size must run at a coarser resolution and does not see the fine grain structures. This project will increase the accuracy of this coupling between LAM and global model. Specifically, the core focus is to utilise deep learning to recover accurate fine grain structures from a coarse global model to be incorporated as boundary data to the LAM. The philosophy followed is that if one wants to couple two models it is paramount to preserve the physical structures between the two models. One may think of such structures as conserved quantities here. In addition to utilising this philosophy to optimise the coupling between models in the traditional (deterministic) sense, new technologies in structure preserving deep learning will be developed. These aim to resolve the fine grain features to be qualitatively consistent with a global model ran at high resolution. This is an interesting problem from a mathematical perspective as it applies expertise from numerical analysis and geometric numerical integration to develop the field of machine learning. This project has been designed to be in line with the UK Met Office atmospheric models and is of high research interest to them.

Keywords: structure preserving deep learning limited area modelling regional weather forecasting geometric numerical integration conservative discretisations
Inequality-aware Market Design (IMD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Poland
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 1191561.0
EU funding (EUR): 1191561.0
Participants: 1
Project status: SIGNED

Policymakers often introduce rules constraining transactions in individual markets—such as rent control—or even choose to distribute scarce resources by circumventing markets completely, as is frequently the case for health care or transit. Yet, traditional economic intuition opposes these sorts of policies because—unlike well-functioning markets—they introduce allocative inefficiency. In this project, I will explore the optimal design of marketplaces in the presence of underlying inequalities between participants, developing a theory of Inequality-aware Market Design (IMD). My approach is to deploy a mechanism-design framework that identifies the optimal way to structure the market. In the baseline framework, the designer maximizes a welfare function whose welfare weights reflect her redistributive preferences induced by the inequalities between participants. Market participants may have private information both about their willingness to trade and their welfare weights. Research will focus on testing the validity and scope of the main hypothesis: When inequalities are sufficiently pronounced and can be detected based on agents’ behavior in the market, it becomes optimal to sacrifice allocative efficiency to achieve a more desirable split of surplus. For example, optimal market designs may involve inefficient rationing. Inequality-aware Market Design provides a novel way to address the growing problem of inequality in market-design settings. The redistributive objective distinguishes this theory from the traditional mechanism-design literature that has focused predominantly on efficiency and revenue as design goals; the focus on optimal allocation rules in a single marketplace complements the public-finance approach to redistribution through the tax system. IMD provides policy guidance by explaining whether and how policymakers concerned about inequality should resort to distortionary market interventions.
Innate Lymphoid Cell Engagers (ILCEs): Targeting Innate Lymphoid Cells through a Bispecific Engager for the Resolution of Chronic Inflammation (ILCE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-07-01
End date: 2026-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Chronic inflammatory diseases, such as rheumatoid arthritis (RA) and spondyloarthropathies (SpA) represent a persistent healthcare challenge, requiring life-long management because of treatments with limited long-term efficacy. The key to a breakthrough may lie in the strategic engagement of Innate Lymphoid Cells (ILCs), whose potential in resolving inflammation and reprogramming tissue memory emerges from the recent ERC-funded research by Rauber et al. (2024). The study published in Nature Immunology elucidates the physiological function of ILCs to control inflammation. Building on this, we propose an innovative ILC engager (ILCE), aiming to harness natural pathways of resolution of inflammation and to offer a significant improvement over anti-cytokine therapies. Our approach bypasses generalized immunosuppression and thereby reduces the risk of infection by maintaining the body's acute inflammatory response. The development of an ILCE holds the promise to gain a new class of precise and efficacious therapeutics for chronic inflammatory diseases, revolutionizing patient outcomes by tailoring treatments to the nuanced pathophysiology of inflammation.
Recognizing European potential for hosting deep land primary CRM by combining new mineral models and advanced exploration and visualization techniques (DEXPLORE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Spain,Greece,Italy,Estonia
Call: Exploration of critical raw materials in deep land deposits (RIA) (HORIZON-CL4-2024-RESILIENCE-01, 2024)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 4669428.75
EU funding (EUR): 4669428.75
Participants: 13
Project status: SIGNED

DEXPLORE seeks to revolutionize mineral exploration in Europe by developing innovative approaches to counter declining ore deposit discovery rates, focusing on deep-seated deposits critical for the economy's decarbonization. The project emphasizes engaging the general public and stakeholders, combining innovation at various levels, and utilizing cutting-edge tools and technologies. Targeting essential materials across extensive geological terrains, DEXPLORE proposes a holistic innovation package, integrating UAV-assisted in-field mineral detection, advanced Earth Observation methods, and novel deep-land geophysics techniques to reach at least 600 m depth. The initiative outlines the development of updated ore models, improving exploration technologies, and providing a visualization platform. This platform will integrate geological, remote sensing, and geophysical data to enhance access to information about EU potential in critical raw materials, while increasing public awareness. DEXPLORE also aims to strengthen cooperation with strategic partner countries, establishing a robust Advisory Board and fostering collaboration with other EU initiatives for joint activities and result sharing. In summary, DEXPLORE represents a collaborative effort to advance mineral exploration, contribute to sustainable sourcing of critical raw materials, and ensure EU's open strategic autonomy.

Keywords: crm,srm,deep land exploration,remote sensing,gravimetry,passive seismic,data visualization,deep seated deposits,holistic innovation package,integrating uav assisted in field mineral detection
Quantum Secure Networks Partnership (QSNP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Framework Partnership Agreement
Countries involved: Spain,France,Denmark,Germany,Netherlands,Italy,Austria,Czechia,Portugal,Belgium,Poland,Malta,Greece,Ireland
Call: Framework Partnership Agreements in Quantum Communications (FPA) (HORIZON-CL4-2021-DIGITAL-EMERGING-02, 2021)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 0.0
EU funding (EUR): 0.0
Participants: 51
Project status: SIGNED

The Quantum Secure Networks Partnership (QSNP) aims at creating a sustainable European ecosystem in quantum cryptography and communication. A majority of its partners are participants in the Quantum Flagship projects CIVIQ, UNIQORN and QRANGE, and include world-leading academic groups, research and technology organizations (RTOs), quantum component and system spin-offs, cybersecurity providers, integrators, and telecommunication operators. The Partnership thus has the expertise in all technology development phases, from new designs to field deployment, making it ideal to carry out the future Specific Grant Agreement (SGA) projects. QSNP is structured around three main Science and Technology (ST) pillars. The first two pillars, “Next Generation Protocols” and “Integration”, focus on frontier research and innovation led mostly by academic partners and RTOs. The third ST pillar “Use cases and Applications” aims at expanding the industrial and economic impact of QSN technologies and is mostly driven by companies. In order to achieve the specific objectives within each pillar and ensure that know-how transfer and synergy between them are coherent and effective, QSNP has established ST activities corresponding to the three main layers of the technology value chain, “Components and Systems”, “Networks” and “Cryptography and Security”. Future SGA projects will be able to efficiently rely on this framework, in such a way that the ultimate objective of developing quantum communication technology for critical European infrastructures, such as EuroQCI, and private information and communication market sectors, will be achieved. QSNP will contribute to achieving European sovereignty in quantum technology for cybersecurity. At the same time, it will generate significant economic benefits to the whole society, including training a new generation of scientists and engineers, and the creation of high-tech jobs in the rapidly growing quantum industry.

Keywords: quantum networks,quantum cryptography,secure communication,quantum encryption,european quantum communication infrastructure,advanced quantum communication protocols
The Waging of War (WOW)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Norway
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2399126.0
EU funding (EUR): 2399126.0
Participants: 2
Project status: SIGNED

Wars are raging around the world. War has terrible consequences: soldiers and civilians are killed or wounded, millions are forced to flee their homes, buildings and infrastructure are destroyed, and children, especially, are put at risk of sickness and death; the suffering is astounding. Some of this is unintended, but too much of the suffering is intentional. Wars are fought in myriad ways, ranging from conventional interstate war to intrastate guerilla insurgencies to terrorist actions. The ways wars are waged have serious consequences. The strategic dynamics between warring parties are crucial in shaping warfare – and thus its consequences – but these aspects are often overlooked. We know much more about the causes of war and ways to end wars than we know about what happens during war. The Waging of War (WOW) project addresses this fundamental research gap, emphasizing the dynamic and evolving nature of the interactions of belligerents, offering new insights into how the organization of warring parties influences the conduct of war, and conversely, how the fighting impacts the organizational structure of the belligerents. War dynamics are important because they determine winners and losers, and the nature of the resolution of conflict. War dynamics also have severe consequences for affected communities and societies and influence the prospects for rebuilding. WOW addresses three central research questions: • How are wars fought? • How does the organization of a belligerent party affect the way they wage war? • How do the dynamics of the war affect the organization of the fighting parties? The project has 3 objectives: • To develop a theory of the dynamics of war with applications to interstate and intrastate conflict. • To apply the dynamics of war theory to specific cases and develop generalizable conclusions. • To develop a data infrastructure about organizational features and aspects of the dynamics of war.

Keywords: warfare,dynamic processes,armed organizations,contestation