Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Crisis, Governance, and Buddhism in Contemporary Bhutan (CRISIS) (CRISIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 263393.28
EU funding (EUR): 263393.28
Participants: 1
Project status: SIGNED

This project aims to expand understanding of workable governance models in times of crisis through an ethnographic study of the role of Bhutan’s Central Monk Body (CMB) in ongoing management of the impacts of the COVID-19 pandemic. The pandemic markedly increased global inequalities, and its socio-economic effects are still being felt in Bhutan. Within this crisis situation, structures of state power are being renegotiated. Bhutan’s historical Buddhist governance model was based on a seamless union between religion and state. The 2008 constitution created a separation between the two, removing the monk body from government. Yet monks seem to be playing a prominent, but little understood, role in Bhutan’s ongoing ‘whole-of-society’ crisis response. This project explores the questions this raises about the workability of Bhutan’s secularist governance model, derived primarily from the Christian West. It also brings this case into dialogue with decolonial research in religious studies, anthropology and governance studies to address the broader question of how governance can be (re)imagined to mitigate crises in resource-poor nations. Bhutan’s acclaimed success in pandemic management and its status as the only sovereign state in the Tibetan and Himalayan region makes it an important case. Yet it is one of the world’s least ethnographically studied places. Drawing on my experience, knowledge and networks as a former government researcher in Bhutan and native anthropologist trained in the West, I will: a) conduct fieldwork to document the CMB’s role in crisis management; b) analyse what this reveals about governance in practice through the lens of Bhutan’s historical Buddhist governance model; c) assess the broader implications for workable governance in times of crisis; and d) apply the findings in policy recommendations. Skills and experience gained through this timely project will facilitate my transition into practice-oriented research as the next stage in my career.

Keywords: ethnography,himalaya and south asia,religion and politics,crisis management,governance
AFB1-generated cGMP targets CNGC14 to trigger rapid auxin responses in plants (A-TARGET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 230184.72
EU funding (EUR): 230184.72
Participants: 1
Project status: SIGNED

Rapid auxin responses initiate cellular changes, which are important for rapid, auxin-induced root growth inhibition and root gravitropism. Accumulating evidence shows that these rapid responses are mediated by TIR1/AFB signaling: Auxin enters the cell by influx or diffusion and activates the AFB1; within seconds, AFB1 activates a trio of tightly connected rapid responses, including PM depolarization, CNGC14-dependent cytosolic Ca2+ increase, and apoplast alkalinization, which lead to rapid root growth inhibition. However, how AFB1 mediates these rapid cellular responses via CNGC14 remains unknown. Until recently, my host lab found that TIR1/AFBs have additional Guanylate cyclase activity and that its product, cGMP, rapidly and transiently increases in roots after auxin treatment. Importantly, application of cell-permeable cGMP triggers cytosolic Ca2+ increase in a CNGC14-dependent manner and rapid root growth inhibition in Arabidopsis. These observations collectively imply a linear AFB1 - cGMP - CNGC14 - Ca2+ non-transcriptional signaling pathway, which explains well at least part of the mysterious rapid auxin responses. However, how the auxin perception product, cGMP regulates CNGC14 and orchestrates Ca2+ influx is still unclear in planta. Thus, filling this major knowledge gap is eagerly awaited and will open entirely new possibilities for a mechanism of cytosolic Ca2+ oscillation in planta. In this proposed research, I aim to test the hypothesis that AFB1-generated cGMP acts as a second messenger, targeting CNGC14 to trigger rapid auxin responses in plants. We will i) clarify the binding between cGMP and CNGC14 in vitro and in vivo; ii) test the importance of cGMP binding to CNGC14 functions in plants; iii) explore the mechanism, by which cGMP regulates CNGC14. My investigation will not only be a significant step in our understanding of non-transcriptional auxin mechanisms but will have huge implications for other rapid, Ca2+-dependent cellular responses.

Keywords: arabidopsis rapid auxin response cgmp second messengers cngc14 calcium transients rapid root growth inhibition root gravitropism
Multifrequency and Machine Learning methods to Search for Early Super Massive Black Holes (ML-SMBH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-12-01
End date: 2025-01-31
Duration (months): 26.0
Total project cost (EUR): 172618.56
EU funding (EUR): 172618.56
Participants: 1
Project status: CLOSED

Early Super Massive Black Holes (SMBH) continuously push our understanding of the formation of galaxies and structures in the Universe. SMBH accreting matter under the radio/jet mode produces powerful relativistic jets and emit beamed non-thermal radiation from radio up to very high energy gamma-rays. Those jets pointing directly to Earth create the so-called Blazar phenomena, where the source appears exceptionally bright due to relativistic magnification (beaming) effects. We can spot Blazars up to high redshifts, but they are rare (given the geometrical alignment constraints involved). To date, only a few distant blazars are known (e.g. QJ0906+6930 z=5.57 and PSO J030947+271757 z=6.1), and a direct search for new ones is impactful because each source at z > 5 implies the existence of thousands of similar misaligned objects. A systematic investigation at z > 5-6 will provide a robust lower limit for the density of Jetted SMBH close and within the Epoch of Reionization (EoR). This research proposal aims to apply Machine Learning (ML) techniques coupled with Multifrequency data to search for high redshift blazars candidates. We plan to select promising z~7 candidates based on the Damping Wing Pattern (DWP). The DWP manifests as the absorption of the observed wavelength λ < 970nm (<121nm, rest-frame) due to neutral gas in the intergalactic medium (IGM) at z > 7 and is very sensitive to the neutral fraction of the IGM. The DWP allows to probe well within the EoR phase and provide a remarkable view into the early Universe. This proposal will leverage fresh survey releases (as the CatWISE2020 in IR and eROSAT Q4-2022 in X-rays) and benefit from the leading role of Instituto de Astrofísica (IA) within ASKAP and MOONS projects (which will provide deep radio data and support for optical observations). This plan will apply ML to a complex Multifrequency data frame in search of high-redshift sources and contribute to establishing the fast-emerging branch of Astroinformatics.

Keywords: active galactic nuclei agn blazars multifrequency data machine learning ml astroinformatics
Resisting Language Inequlity/ Resistir la Desigualdad Lingüística (ReDes_Ling)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Luxembourg,Denmark,Argentina,Mexico,Colombia
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 768200.0
EU funding (EUR): 768200.0
Participants: 10
Project status: SIGNED

ReDes_Ling is an interdisciplinary and inter-sectoral action research project whose goal is to research language inequality and propose innovative strategies to revert its pernicious social effects, promoting sociolinguistic justice and social integration. Building a network of twelve organizations from Europe (Denmark, Greenland, Luxembourg, Spain) and Latin America (Argentina, Colombia, Mexico) that brings together scholars and social actors (grass-roots indigenous and workers' organizations, cultural institutions, media outlets), ReDes_Ling focuses its action research on three key areas that are fundamental pillars of economic and social prosperity: education, health, and work. To understand and reverse inequalities mediated by social and linguistic issues, ReDes_Ling proposes a three-prong action plan: redistribution of material and symbolic resources, recognition of all languages and speakers, and participation of all communities in social and political life. With this approach, ReDes_Ling will generate four outcomes: (1) a groundbreaking interdisciplinary and inter-sectoral framework to understand and tackle language inequality; (2) a corpus of actions to respond to language inequality that the network will design, implement, and assess; (3) an inventory of interventions to promote an alternative discourse to foster sociolinguistic justice, also designed, implemented, and assessed as part of the action; and (4), a series of materials to intervene in society so that the research and innovation produced by ReDes_Ling reaches our broad immediate social and academic circles, extended populations in the countries where the network operates, and stakeholders and policy makers at the regional, national, and European levels. Our project contributes to the EU's goals of excellence in R&I, raising democratic values, promoting gender equality, increasing political participation, and strengthening strategic international relationships.
Receptor Ectodomain Shedding in Plant Immune Signal Transduction (RESIST)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

Receptor ectodomain shedding (shedding) is a fundamental mechanism of the regulation of communication between mammalian cells. Shedding refers to the proteolytic cleavage of the extracellular portion of a membrane protein. This process can inactivate the function of a receptor, generate extracellular signalling molecules and trigger the generation of intracellular protein forms involved in signalling. Shedding is best understood in mammals, with hundreds of shedding events reported, but also occurs in other animals and fungi. A few cases of shedding have been observed in plants. Membrane receptor like kinases (RLKs) constitute the main players of cell-to-cell communication in plants, with many of them serving as key immune receptors. RLK shedding has been reported in two occasions, pointing to an important regulatory function. Despite the essential functions of shedding in animals, the biological significance of RLK shedding in plants, and the fact that plant cells harbour many more receptors than their animal counterparts, shedding has yet to be studied systematically in plants. By reanalysis of large scale extracellular proteome datasets, I found evidence of widespread RLK shedding events in plants. However, this analysis could not reveal exact cleavage sites that are important for follow up functional studies. Trough RESIST, I seek to develop this new field of ectodomain shedding in plant biology and study the mechanisms of regulation and the consequences of plant RLK shedding. To do so, I aim to establish a platform for experimental identification of shedding events in plants by adapting cutting edge methods recently developed in medical sciences for precise identification of processed membrane proteins and released ectodomains in Nicotiana benthamiana. I will use this platform to analyse the plant sheddome (the repertoire of shed proteins) and its dynamics upon defence activation and to identify interesting shedding events for functional characterization.

Keywords: nicotiana benthamiana,ectodomain shedding,receptor like kinase,terminomics,plant
Tracking Long-Term Resilience in Arctic Sociocultural-Ecological Systems (TRACES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499952.5
EU funding (EUR): 1499952.5
Participants: 1
Project status: SIGNED

Like many Indigenous peoples around the world, Inuit of Foxe Basin, central Arctic Canada, view hunting and the food security it provides to be a collective cornerstone of their cultural identity. However, much conflict exists between Inuit subsistence hunters and regulators over the population sizes of many animal species (e.g., caribou, walruses, and polar bears) and the continued sustainability of hunts; Inuit argue that government-sponsored stock estimates are too conservative, and that hunting quotas are too low. My aim is to better understand and navigate the cultural disjuncture between Western-scientific understandings of sustainability/conservation, and Inuit traditional knowledge about environmental health. My team and Inuit partners will, for the first time, generate and integrate different types of data on: (1) present-day hunting patterns (through citizen science); (2) past animal-resource use by Inuit in Foxe Basin, from ca. AD 1300 (through archaeological investigations); (3) traditional knowledge about hunting and use of animal resources in the region (through ethnographic engagement); and (4) policy relating to modern and historical hunting regulation and conservation efforts. A fifth work package will offer practical, data-driven solutions for better relationships between Inuit and policymakers and regulators through the creation of a multimedia Toolkit that can be used by rights-holders in cross-culturally framing, discussing, and ultimately, (re)affirming rights over the resources in their traditional territories. TRACES will greatly further our archaeological and anthropological understanding of long-term animal use by Arctic Indigenous peoples and will have significant implications for how we categorize humans, animals, and whole biomes as being vulnerable to climate change. Ultimately, the project will serve as a model for environment-related Indigenous research and policy action elsewhere in the world.

Keywords: subsistence hunting indigenous issues inuit arctic trans disciplinary methods policy and regulation decolonization climate change conservation
To develop a new targeted therapy for the treatment of naive and PARP inhibitor-resistant BRCA1/2-mutated tumors (TargetBRCA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-08-01
End date: 2024-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Breast and ovarian carcinomas are aggressive tumors with few treatment options and high recurrence rates. About half of these tumors shows defects in homologous recombination (HR) repair. Defect in HR (HRD) causes genomic instability and dependence on poly (ADP-ribose) polymerase (PARP)-mediated DNA repair. As a result, PARP inhibitors (PARPi) are now widely used for the treatment of these tumors. However, resistance to PARPi is emerging as the major obstacle to clinical effectiveness. Consequently, many patients run out of treatment options and succumb to the disease. This prompts the development of novel therapeutics. Beyond its well-known functions in regulating metabolic processes, we discovered that enzyme X maintains genomic stability in HRD cells. Enzyme X inhibition kills HRD cells without affecting HR-proficient cell survival pointing to a synthetic lethal interaction between enzyme X and HR genes. Moreover, we showed that enzyme X functions independently of PARP in the survival of HRD cells. As a result, enzyme X inhibition kills naive and PARPi-resistant HRD cells. Thus, targeting this enzyme has the potential to provide a new cure for HRD tumors. No inhibitors nor patents on enzyme X exist. HRD tumors being a major economic burden worldwide, developing enzyme X inhibitors has high innovation and financial reward potentials. By screening chemical libraries, we identified a top hit inhibitor of enzyme X. Our TargetBRCA project aims at improving potency and specificity of our molecule inhibitor and provides a proof-of-concept on its use as a cure for HRD tumors. TargetBRCA relies on complementary teams of crystallographers, chemists and specialists of HRD tumor biology and associates structure-aided drug design with the use of preclinical in vivo models. Our ultimate goal is to foster the development of a clinical-grade inhibitor to be used for the treatment of HRD tumors either by licensing and co-development partnerships, or by the creation of a start-up.
TWINNING GREEN-EDITING VIBES FOR FϴϴD (CREDIT Vibes)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Serbia,Slovenia,Greece
Call: Twinning Western Balkans Special (HORIZON-WIDERA-2021-ACCESS-02, 2021)
Start date: 2023-01-01
End date: 2026-03-31
Duration (months): 39.0
Total project cost (EUR): 1456250.0
EU funding (EUR): 1456250.0
Participants: 3
Project status: SIGNED

CREDIT Vibes presents a cloud of Creativity, Research, Education, Development, Innovation, and Transformation (CREDIT) where the training of the highly-skilled researchers and non-research staff is the priority. CREDIT Vibes are launched healthy food/feed, a healthy eco-friendly environment, and healthy life on a healthy planet. It was guided by the idea that if Maize Research Institute from Serbia is structurally transformed and thus improved transfer of agro-technology and agro-knowledge and increase number of manageable projects, other institutions in Serbia and the region will copy that pattern and enhance-self. When several smaller micro-transformations come together, the community's interest rises to the global level, and excellence is born. The main project's objectives are to transform and access excellence following the scientific and technology roadmaps and thus extend networking and collaboration in the region and Europe Research Area. CREDIT Vibes expects broader scientific, economic, and societal effects in raising the excellence of Maize Research Institute, which will open new science pathways and thus increase the number of manageable projects. Furthermore, increasing the transfer of agro-knowledge and agro-technologies into the economy by 15% will be the main long-term propeller of economic growth.

Keywords: breeding,soybean,maize,organic,food,feed,transformation,education,trainings,networking,staff exchange
Instrument-free 3D molecular imaging with the VOLumetric UMI-Network EXplorer (VOLUMINEX)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden,France,Netherlands
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 2999999.25
EU funding (EUR): 2999999.25
Participants: 5
Project status: SIGNED

Current molecular imaging and spatial transcriptomics methods are limited in throughput and affordability, and are constrained by inherent 2-dimensionality. We propose the Volumetric UMI Network Explorer (VOLUMINEX), a 3D implementation of sequencing-based microscopy. This radical alternative to optical imaging builds spatial molecular maps by sequencing DNA barcode networks where each node is a clonally amplified DNA patch, and each edge indicates inter-node proximity. The resulting network reveals gene identities along with their locations without a reference map. We propose an end-to-end pipeline starting with a tissue, followed by enzymatic processing steps, and ending with sequencing and a computational reconstruction to form a molecular image. We envision this procedure as an off-the-shelf commercial kit, offering an inexpensive alternative to advanced imaging instrumentation, expanding access to more researchers and potentially even clinical diagnostic settings. We are led by a Stockholm-based tech-dev team with seminal contributions to the field of sequencing-based microscopy, and a Stockholm-based company Single Technologies AB with a proprietary 3D sequencing device uniquely suited for validating our technology. We have partnered with an Utrecht-based team of life scientists to develop and deploy our technology on organoids, a rich controllable model tissue-like system perfect for exploring 3D biological imaging. Finally, at the heart of the project are undiscovered laws and physical principles which we aim to uncover and exploit with our Paris-based team of theoreticians, who will develop optimisation, graph theory, and machine learning algorithms to tackle the challenging computational problem of spatial reconstruction presented by sequencing-based microscopy. Through VOLUMINEX, we aim to kick off a new era of molecular imaging where comprehensive spatial and transcriptomic data is accessible, affordable, and 3-dimensional.

Keywords: spatial transcriptomics,3d imaging,molecular networks,sequencing based microscopy,dna microscopy,organoids