Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Pemphigus - From autoimmunity to disease (PEMPHIGUS)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Germany,Italy,Germany,Switzerland,Germany,France
Call:  (FP7-HEALTH-2007-A, 2007)
Start date: 2008-05-01
End date: 2011-10-31
Duration (months): 42.0
Total project cost (EUR): 3693527.6
EU funding (EUR): 2819400.0
Participants: 7
Project status: CLOSED

Pemphigus is a potentially lethal bullous disease of the skin and mucosa and may be considered as a paradigmatic organ-specific autoimmune disease due to 1) its well-defined autoantigens, 2) the knowledge of critical events of its immune pathogenesis and 3) the reproducibility of major clinical and pathogenic features in suitable animal models. Overall, understanding the etiopathogenesis of pemphigus may provide crucial additional insight into basic mechanisms leading from autoimmunity to autoimmune disease and may help to design more specific therapeutic strategies. Despite the enormous progress, no specific therapy is currently available in pemphigus. The present project arises as a joined effort of European Scientists and Clinicians to establish a Consortium of groups engaged in providing a critical mass of patients and research tools to address the following goals: 1) to better define the immune pathogenesis of pemphigus utilizing two in vivo models of pemphigus with emphasis on autoaggressive T cells and their collaboration with autoantibody (autoAb) secreting B cells. 2) analysis of the autoAb-driven effector phase frequently involving “epitope spreading” which ultimately leads to a more severe disease; 3) characterization of the molecular events following Ab binding to the target autoantigens by defining autoAb-induced signalling events in epidermal keratinocytes; 4) spectrum of the autoimmune B cell response and the impact of therapeutic strategies on the cellular and humoral autoimmune response in pemphigus utilizing human monoclonal Ab which will be analysed for their fine specificity and genetically and functionally characterized; and 5) clinical read-out parameters for prospective studies which are urgently needed as valid parameters for the extent and activity of disease and which will be compared to serological markers and life quality assessment in pemphigus.

Keywords: pemphigus,autoantibody,clinical score,autoreactive t cells,treatment,effector phase,orphan disease,epitope spreading,tolerance,human leukocyte antigens,prospective study
Multi-scale analysis of models for phase change (MUSAPH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2007-09-01
End date: 2011-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

There is a broad spectrum of problems in scientific disciplines that are dominated by the nonlinear interaction of physical processes across many length and time scales, ranging from the microscopic to the macroscopic. The evolution laws governing such phenomena on macroscopic scales describe quantities which are derived by averaging over many degrees of freedom of a finer length scale. The deviations from this average due to thermal effects or material impurities are often negligible. In some situations, however, they can trigger effects which are observable on the macroscopic length scale. The topic of this proposal is to develop a mathematical methodology which is suitable for a rigorous mathematical analysis of the effects of thermal fluctuations ("noise") and/or spatial heterogeneities on large spatial and temporal scales by focusing on a special type of partial differential equations, the so-called reaction-diffusion equations. These are widely accepted as modeling important qualitative features of e.g. materials with different phases, but are as well used in other applied areas, like mathematical biology.

Keywords: physical sciences,applied mathematics
Chemical Processing by Swarm Robotics (CHOBOTIX)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Computer science and informatics
Countries involved: Czechia
Call:  (ERC-2007-StG, 2007)
Start date: 2008-06-01
End date: 2013-05-31
Duration (months): 60.0
Total project cost (EUR): 1644000.0
EU funding (EUR): 1644000.0
Participants: 1
Project status: CLOSED

The aim of the project is to develop chemical processing systems based on the principle of swarm robotics. The inspiration for swarm robotics comes from the behaviour of collective organisms – such as bees or ants – that can perform complex tasks by the combined actions of a large number of relatively simple, identical agents. The main scientific challenge of the project will be the design and synthesis of chemical swarm robots (“chobots”), which we envisage as internally structured particulate entities in the 10-100 µm size range that can move in their environment, selectively exchange molecules with their surrounding in response to a local change in temperature or concentration, chemically process those molecules and either accumulate or release the product. Such chemically active autonomous entities can be viewed as very simple pre-biotic life forms, although without the ability to self-replicate or evolve. In the course of the project, the following topics will be explored in detail: (i) the synthesis of suitable shells for chemically active swarm robots, both soft (with a flexible membrane) and hard (porous solid shells); (ii) the mechanisms of molecular transport into and out of such shells and means of its active control; (iii) chemical reaction kinetics in spatially complex compartmental structures within the shells; (iv) collective behaviour of chemical swarm robots and their response to external stimuli. The project will be carried out by a multi-disciplinary team of enthusiastic young researchers and the concepts and technologies developed in course of the project, as well as the advancements in the fundamental understanding of the behaviour of “chemical robots” and their functional sub-systems, will open up new opportunities in diverse areas including next-generation distributed chemical processing, synthesis and delivery of personalised medicines, recovery of valuable chemicals from dilute resources, environmental clean-up, and others.

Keywords: distributed processing,particle technology,autonomous agents,chemotaxis,homeostasis,molecular transport,chemical robots.
Encoded Cellular Synthesis of Unnatural Biopolymers (ECSUB)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: United Kingdom
Call:  (ERC-2007-StG, 2007)
Start date: 2009-01-01
End date: 2014-12-31
Duration (months): 72.0
Total project cost (EUR): 1782918.0
EU funding (EUR): 1782918.0
Participants: 1
Project status: CLOSED

We are building a parallel and independent (orthogonal) translational machinery for the encoded biosynthesis of unnatural polymers in living cells. The orthogonal translation system has many potential applications beyond those possible with the natural translation system: I propose to use it: 1) To expand the chemical scope of monomers that can be polymerized by the ribosome in living cells, allowing the incorporation of monomers with unnatural backbones into proteins; 2) To increase the efficiency of in vivo unnatural amino acid mutagenesis via amber suppression, so that no truncated protein is produced and multi-site incorporation of unnatural amino acids is possible; 3) To create probes of protein function for use in vivo; 4) To free numerous codons for simultaneous encoding of multiple distinct unnatural monomers, and to experimentally explore alternate genetic codes; 5) To explore the evolution of encoded unnatural polymers toward new cellular functions.

Keywords: synthetic biology,ribosome engineering,genetic code expansion
The use of Methylated DNA Immunoprecipitation MeDIP in cancer for better clinical management (CANCERDIP)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Spain,Belgium,Netherlands,Italy,Germany,Belgium,Spain
Call:  (FP7-HEALTH-2007-A, 2007)
Start date: 2008-01-01
End date: 2011-06-30
Duration (months): 42.0
Total project cost (EUR): 3922042.97
EU funding (EUR): 2999994.0
Participants: 7
Project status: CLOSED

Aberrant DNA methylation is the most common molecular lesion of the cancer cell. Neither gene mutation nor cytogenetic abnormalities are as common in human tumours as DNA methylation alterations. The stability of our genome and correct gene expression is maintained to a great extent thanks to a perfectly preestablished pattern of DNA methylation and histone modifications. In cancer this idealistic scenario breaks down due to an interesting phenomenon whereby the regulatory regions (CpG islands) of certain tumour suppressor genes become hypermethylated, inactivating the gene as a consequence, whilst a wave of hypomethylation occurs in the genome. Indeed, CpG island promoter hypermethylation has a tumour-type-specific pattern, where each gene tends to be methylated in the cancer cells driven from a particular tissue, but not from others. It is also widely accepted that the multiprotein complex associated with the methylated DNA is also crucially involved in the repression of gene expression. Another aspect crucial for the interest of epigenetics in cancer is that promoter hypermethylation of the CpG island of tumours suppressor genes occurs early in tumorigenesis. Furthermore, it has been extensively reported that CpG promoter hypermethylation can be used as predictor of cancer behaviour and a predictor of response to treatment. This characteristic makes promoter hypermethylation combined with the epigenetic associated proteins profile, a potential biomarker for early detection of cancer and for the individualization of cancer treatment. We are going to use a novel technique based in chromatin immunoprecipitation, the Methylated DNA Immunoprecipitation (MeDIP) technique that will easily permit us to obtain an epigenomic profile which will be used to personalize cancer treatment and facilitate tumour diagnosis, prognosis and monitoring.

Keywords: cancer,epigenetics,dna methylation,dna immunoprecipitation,medip,chromatin-modifying protein complexes.
The innovation in the plan of the current floor: Zoning in blocks of flats for the middle class in the first half of the 20th century (PIANO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Romania
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2007-12-15
End date: 2010-12-14
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

In Nouvelles Impressions d’Architecture, Libeskind (1998) writes "When architecture no longer deals with Space, all transactions, in which the container and the contained twisted together […] have come to an end". A systemic analysis can be performed morphologically, functionally or dynamically. The connection between the appearance and the generation of the form, human perception and experience, the processional nature of any system, is considered. The buildings of the Modern Avantgarde were raised during a very short time span of 20, sometimes just 10 years, in several different parallelly coexisting styles, coexisting also with newest developments in music, arts, physics, philosophy, economic and social theory and industrialisation. One of the nuclei of the movement was built by the housing programme, particularly suitable to foster innovation. While in more industrialised countries ways to solve social problems were seeked for, in the other European countries the new possibilities were seen as an opportunity to give a more prosperous image to cities, by raising density with blocks of flats for the middle class. The study will concentrate on European features of building stock which have not been covered by previous studies, namely the spatio-functional research of the interior organisation of the dwelling in the blocks of flats for the middle class. The study proposes a heterogeneous model in which a zone has instead of a unique function a unique vocation. Zoning results as a structural product in the superposition and interpenetration of textures (sub-systems of the life-frame elements able to respond to the functionally requested situation) of morphologic elements, thanks to the co-operation process of human activities. There is a complex zoning with operational and organisational value. As case studies will be considered: - Milan 1920-1940; - Bucharest 1920-1940; - Athens 1919-1939; - forerunners of and Avant-Garde in Budapest 1896-1939.

Keywords: spatial design,building design,interior design,social anthropology
New Migrant Socialities: Ethnic Club Cultures in Urban Europe (MIGRANT SOCIALITIES)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Institutions, values, beliefs and behaviour
Countries involved: Germany
Call:  (ERC-2007-StG, 2007)
Start date: 2009-04-01
End date: 2013-03-31
Duration (months): 48.0
Total project cost (EUR): 1244517.6
EU funding (EUR): 1244517.6
Participants: 1
Project status: CLOSED

The project investigates new forms of sociality that young people with migrant background are producing in the context of urban club cultures in three European cities. It comparatively studies the phenomenon of ethnic club scenes with Turkish, South Asian and Maghrebi orientations in Berlin, London and Paris, corresponding to the major immigrant groups in each city and country. The project aims to explore how migrants participate in forms of social engagement and cultural experimentation that are specific to metropolitan city life, but have so far been not been addressed as relevant to the lives of ethnic minorities. Research seeks to shift attention from the predominant research focus on migrant identity to a focus on migrant practices of sociality, countering the heavy bias towards the study of attitudes and cultural identifications that tends to dominate across different disciplines. Its novel approach combines a focus on socio-cultural practices with an interest in urban scenes as fluid social formations that are semi-public and lack defined membership or criteria of belonging. Through ethnographic case studies carried out with a team of researchers in and across the three cities, the project explores the potential of urban club scenes for producing and experiencing different kinds of solidarity and encounter among disadvantaged groups.

Keywords: sociality,youth cultures,urban transformations
Road Map for Diabetes Research in Europe (DIAMAP)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Coordination and support actions
Countries involved: Germany
Call:  (FP7-HEALTH-2007-A, 2007)
Start date: 2008-04-01
End date: 2010-09-30
Duration (months): 30.0
Total project cost (EUR): 610524.0
EU funding (EUR): 530970.0
Participants: 1
Project status: CLOSED

EURADIA, the Alliance for European Diabetes Research, encompasses in one entity the major European diabetes stakeholder organisations, ensuring contact and credibility with scientists in all fields of diabetes research. EURADIA has a unique and high profile at European level and is the primary contact for the European Commission in diabetes research issues. EURADIA has been instrumental in highlighting the need for increased and better coordinated funding for diabetes research. A Project Steering Committee of high-profile EURADIA members (from patient organisations, academic science and industry) will provide scientific guidance for the DIAMAP project. The solid scientific backing for DIAMAP, patient input, and established tools such as a website and database, and links with the Innovative Medicines Initiative, provide credibility for DIAMAP to survey the European diabetes research landscape and to invite input from experts (through expert scientific fora in different diabetes research areas) to produce ‘Road Maps’ for diabetes research. Road Maps will be compiled into a single report to provide the European Commission, funding agencies and researchers with a strategy to maximize the strengths and opportunities for future diabetes research in Europe. Stakeholders will participate through fora for horizontal issues: legal, ethical, health professional. The final diabetes Road Maps will be disseminated widely in the form of an expert report. The mission of DIAMAP is to undertake a wide survey of the current European diabetes research landscape, from which expert opinion can identify gaps and highlight strengths, to guide a Road Map strategy for diabetes research in Europe.

Keywords: diabetes europe survey database expert groups strategic planning diabetes road maps
An inquiry into the health and safety at work; a European Union perspective (HEALTHATWORK)

Framework: FP7 — Cooperation
Programme: Health
Destination: Other Actions across the Health Theme
Action type: Coordination and support actions
Countries involved: United Kingdom,France,Denmark,France,Spain,Greece,Netherlands,United Kingdom,Belgium,Spain,Poland,United Kingdom,Italy,Finland,Germany,Latvia,Hungary
Call:  (FP7-HEALTH-2007-A, 2007)
Start date: 2008-08-01
End date: 2012-01-31
Duration (months): 42.0
Total project cost (EUR): 1216332.4
EU funding (EUR): 1046444.0
Participants: 20
Project status: CLOSED

This proposal aims to review current knowledge and issues related to the economic impact of health at work, to assemble, organise, analyse and synthesise data from national projects and surveys, and to recommend future actions for research and policy development aiming at improving health and safety at work in a changing labour market environment in the European Union in an era of ageing populations, feminised labour markets and increased incidence of Small and Medium Enterprices (SMEs). This is achieved through co-ordinated reviews, the development of common databases regarding indicators of health and safety at work in the participant countries (including the incidence of accidents and illnesses of work, the incidence of absenteeism, and early retirement due to accidents/illnesses at work,) and the associated GIS analysis capability. In addition, a pilot study aiming at designing appropriate data collection protocols is designed to explore the appropriateness of small scale surveys, using purpose-build questionnaire, to determine the preference setting of both employers and employees with regard to health and safety at work and to highlight the cost and benefits of investing in improving the health and safety at work. The above lead to a series of co-ordination meetings and workshops at which the status of health and safety at work, its repercussions for the quality of work and its effects on Europe’s competitiveness are reviewed and studied. A comparative EU-wide assessment of the structure and dynamics of the health and safety at work is carried out. Policy recommendations aiming at improving the health and safety at work in the context of changing labour market environment are detailed with particular reference to the ageing population, the feminisation of the labour markets and the increased incidence of SMEs.

Keywords: health at work,safety at work
OpenTox - An Open Source Predictive Toxicology Framework (OPENTOX)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: Bulgaria,Italy,Germany,Germany,Greece,Russian Federation,Switzerland,United Kingdom,India
Call:  (FP7-HEALTH-2007-A, 2007)
Start date: 2008-09-01
End date: 2011-08-31
Duration (months): 36.0
Total project cost (EUR): 3775680.0
EU funding (EUR): 2975360.0
Participants: 11
Project status: CLOSED

The goal of the OpenTox project is to develop a predictive toxicology framework with a unified access to toxicological data, (Q)SAR models and supporting information. It will provide tools for the integration of data from various sources (public and confidential), for the generation and validation of (Q)SAR models, libraries for the development and integration of new (Q)SAR algorithms, and validation routines. OpenTox will attract toxicological experts without (Q)SAR expertise as well as model and algorithm developers. It will move beyond existing attempts to solve individual research issues, by providing a flexible and user friendly framework that integrates existing solutions and new developments. OpenTox will be relevant for REACH as it gives risk assessors simple access to experimental data, (Q)SAR models and toxicological information that adheres to European and international regulatory requirements. OpenTox will be published as an open source project to allow a critical evaluation of its algorithms, to promote dissemination, and to attract external developers. Facilities for the inclusion of confidential in-house data and for accessing commercial prediction systems will be included. OpenTox will contain high-quality data and (Q)SAR models for chronic, genotoxic and carcinogenic effects. These are the endpoints with the greatest potential to reduce animal testing. The impact of OpenTox will however go beyond REACH and long-term effects, because it will be straightforward to create models for other endpoints (e.g,. sensitisation, liver-toxicity, cardio-toxicity, ecotoxicity). The proposed framework will support the development of new (Q)SAR models and algorithms by automating routine tasks, providing a testing and validation environment and allowing the easy addition of new data. For this reason we expect, that OpenTox will lead to (Q)SAR models for further toxic endpoints and generally improve the acceptance and reliability of (Q)SAR models.

Keywords: (q)sar,in silico,predictive toxicology,reduction of animal experiments,open source