Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Immunometabolic regulation of microglia function in stroke recovery (ImmunoMet)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-01
End date: 2027-01-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Stroke is one of the leading causes of death and disability worldwide. Despite recent improvements in stroke prevention and acute treatment, there is still a very urgent need for promoting stroke recovery to improve patients’ quality of life. Microglia are the predominant brain resident immune cells, in charge of brain homeostasis through immune surveillance. Emerging evidences suggest that post-stroke microglial reactivity remains incompletely resolved and persists chronically. ImmunoMet aims to study the impact of persistent inflammatory and dysfunctional traits of microglia during stroke recovery through metabolic reprograming, a set of essential processes key to satisfy the high energetic requirements of immune activation. To fulfill this goal, ImmunoMet will use novel and cutting-edge methodologies, including sophisticated imaging techniques, multiparametric flow cytometry, metabolomics and single-cell RNA sequencing, to investigate the time course evolution of microglia immunophenotype and the potential shifts in microglial metabolic pathways over the course of stroke. ImmunoMet will also evaluate the effects of an acute manipulation of microglia cellular metabolism on the stroke recovery, as an approach to tackle chronic neuroinflammation and improve brain functional recovery after stroke. To this end, ImmunoMet aims to assess microglia immunophenotype in two scenarios: (1) a transgenic mouse line with altered microglia type I IFN signaling, which may regulate energy metabolism, and (2) after administering an itaconate derivate, a modulator of immune cell polarization. ImmunoMet is expected to contribute novel and valuable insights into the immunometabolic adaptations to stroke. This research will be a crucial for future development of therapies aimed at enhancing the long-term recovery of stroke survivors, addressing a significant socio-healthcare challenge. ImmunoMet will be a major step in my academic career as an international independent researcher.

Keywords: neuroimmunology,stroke,recovery,microglia,metabolism
Augmented PhOtovoltaic ceLLs-based Optical Neural networks for environmental monitoring (APOLLON)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-11-01
End date: 2027-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

APOLLON aims to develop a novel solar-cell-based optical neural network (ONN) designed for real-time, energy-efficient environmental monitoring and object recognition. By leveraging solar cells as both sensors and network nodes, the ONN eliminates the need for conventional cameras and external power sources, significantly reducing energy consumption and system complexity. The integration of metasurfaces enhances the system’s optical sensitivity and spectral selectivity, enabling more accurate detection and classification of objects based on light patterns and colours. This innovative approach allows for scalable, self-powered sensor networks capable of continuous operation in remote and hard-to-reach locations. By addressing the challenges of energy consumption, scalability, and real-time data processing, this project aims to deliver a transformative solution that meets the growing demand for sustainable, cost-effective environmental monitoring and establishes a foundation for future commercialization and global deployment.
Translation in cellular context: Elucidating function, organization and regulation with near-atomic models in whole cells (TransFORM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,United States
Call: ERC Synergy Grants (ERC-2023-SyG, 2023)
Start date: 2024-02-01
End date: 2030-01-31
Duration (months): 72.0
Total project cost (EUR): 13998670.0
EU funding (EUR): 13998670.0
Participants: 3
Project status: SIGNED

Translation – the fundamental process of protein synthesis catalyzed by ribosomes - has been extensively characterized from a biochemical, structural, and mechanistic perspective. However, how exactly the translation machinery operates as an interconnected system of millions of ribosomes in cells is poorly understood. Within the cell, ribosomes associate with a multitude of regulatory proteins forming a variety of specialized complexes and distributing across cellular space in a manner that depends on cell state. What is the specific composition of those complexes, their significance, and their functional role? How are they defined and regulated by subcellular compartmentalization? How do they change in response to cellular stress? Our TransFORM synergy team brings together experts in method development for in-cell structural biology and the biology of translation to allow us for the first time to attack these fundamental problems. Building on our prior achievements, we aim to synergistically develop novel methods of cryo-electron tomography with imaging across scales in conjunction with crosslinking mass spectrometry and integrative structural modeling for near-atomic structure determination directly in cells. TransFORM will determine the ribosome structural and functional states across the translation cycle in human cells, following distinct 40S, 80S, and disomal particles (80S+80S), in and out of polysomes and across different protein synthesis regimes. We will uncover structural and compositional changes and regulatory mechanisms across cellular space, in adaptation to perturbations by stressors and during viral infection. Our model systems will span from single cells to organoids. TransFORM will provide a detailed and comprehensive in-cell map of the essential process of protein synthesis while delivering innovative methods for the next-generation of in-cell structural biology.

Keywords: in cell structural biology,translation,human cell models,ribosomes,heterogeneity,structural biology,cell biology,cryogenic electron tomography,crosslinking mass spectrometry,structural modeling,integrative modeling
Sustainable Development Goals - Enhanced monitoring through the family of copErnicus Services (SDGs-EYES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Italy,Austria,Romania,Netherlands,Belgium,Spain
Call: Copernicus evolution for cross-services thematic domains (HORIZON-CL4-2021-SPACE-01, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2814462.5
EU funding (EUR): 2814462.5
Participants: 10
Project status: SIGNED

The UN 2030 Agenda for Sustainable Development is a data driven agenda, and the use of Earth Observation (EO) can make the SDG indicators’ monitoring and reporting viable, technically, and financially, and comparable across countries. SDGs-EYES aims at boosting the European capacity for monitoring the SDGs based on Copernicus, building a portfolio of decision-making tools to monitor those SDG indicators related to the environment from an inter-sectoral perspective, aligning with the EU Green Deal priorities and challenges. SDGs-EYES will establish an integrated scientific, technological and user engagement framework overcoming the knowledge and technical barriers that prevent the exploitation, combination and cross-feeding of data and tools from the Copernicus’s six core Services, its space-based and in-situ components, and other platforms and portals. SDGs-EYES considers three interconnected SDGs, on climate (SDG13), ocean (SDG14) and land (SDG15), to demonstrate through four Pilots the Copernicus potential for monitoring six indicators making part of the EU and national assessments: GHG emissions, temperature deviation, ocean acidification, marine eutrophication, forest cover change and soil erosion. Although focusing on the biosphere, these indicators are linked to other SDGs on socio-economic and (geo)political factors (e.g., human health, resources security, poverty, conflicts, displacements). Thus, an additional cross-goals indicator and Pilot will focus on vulnerable communities under cumulative climate extreme hazards. SDGs-EYES seeks to combine the science-informed (top-down) approach with a stakeholder-driven (bottom-up) approach to transfer scientific outcomes into easy-to-understand and easy-to-use actionable information in the context of SDG indicators’ assessment. Decision-making tools delivered by Pilots will be co-designed with users, to offer opportunities to regularly assess and refresh methodologies they adopt for monitoring and reporting.

Keywords: earth observation,sustainable development,biosphere,user uptake,agile approach
Moving ForwARd to achieving CLIMATE-resilient and sustainable European regional economic systems (FARCLIMATE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Research and Innovation actions
Countries involved: Spain,Switzerland,Portugal,Italy,Belgium,Finland,Greece
Call: Transformation of regional economic systems for climate resilience and sustainability (HORIZON-MISS-2022-CLIMA-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 4723433.75
EU funding (EUR): 4723433.75
Participants: 14
Project status: SIGNED

FARCLIMATE will address the critical challenges of developing and expanding climate-resilient measures, making them available and understandable to everyone, while also paying special attention to the social, political and economic barriers that are commonly found. FARCLIMATE actions will be implemented in at least 20 regions and communities in Europe, i.e., case studies where we will address transformative solutions on the path to climate resilience. In order to achieve such a great challenge, FARCLIMATE has set the following work program: 1) Initial work on engaging with all relevant stakeholders in each region, setting governance management mechanism; 2) Establishment of living labs to perform co-creation, testing, experimenting and scaling-up innovative activities in real-life environments; 3) A deep research of the main value chains, of the socioeconomic and environmental characteristics and of the existing economic sectors, through indicators to be monitored, of all investigated regions and communities; 4) Establishment of the transversal actions to be performed in all case studies: tailor-made training activities for communities empowerment, targeting different types of stakeholders and based among climate change and related hazards and risks; 5) The implementation of technical but also socially feasible innovative solutions in the agriculture, forestry and fisheries economic sectors, with specific solutions to increase their capacity to adapt to climate change impacts on their fields. Nature-based solutions will be the guiding thread in FARCLIMATE innovative actions; 6) The creation of different tools to spread the obtained learnings, found barriers, and successful results, among others, during FARCLIMATE, such as policy recommendations, guidelines, management plans and the innovative Transformation Hub.

Keywords: climate resilient societies,transformative hub,consumers analysis,innovative solutions,living labs,closed to nature silviculture,eu taxonomy,climate change adaptation,resilience
Novel Strategies for the Assembly of sp3 Carbon–Boron Bonds. Development of Multicomponent Reactions of Boryl Radicals Using Photocatalysis. (BROCA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Boron-containing small organic molecules are fundamental building-blocks in synthetic chemistry due to their use in the Nobel Prize-winning Suzuki cross-coupling. The invention of novel chemical reactions that form carbon–boron bonds in unprecedented ways is of strategic importance to facilitate the discovery, evolution and manufacture of molecules that impact our society. The overarching aim of this project is to explore a conceptually novel approach where sp3 carbon–boron bonds are assembled through the reactivity of B-centred radicals (boryl radicals). Here we propose to develop unprecedented multicomponent reactions based on the photocatalytic generation of boryl radicals from homo-allylic amine-boranes, followed by their cyclization and then diversification through a final reaction with a broad range of trapping agents. This novel synthetic approach will provide a novel class of borylated building blocks that have not been prepared before and we will study their application in metal-catalysed cross-couplings. This methodology will be applied to streamline the preparation of difficult-to-make drug analogues. The proposal capitalizes on recent developments of the host group that pioneered the use of amine-boranes in photoredox catalysis for boryl radical generation and utilization. The development of this innovative project at RWTH Aachen will create new tools in bio-organic chemistry and facilitate the preparation of high-value materials. Its implementation will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my future career following the training plan envisioned.

Keywords: boryl radicals photocatalysis borylation cross coupling amine boranes radical cascade
DEMONSTRATION AND MODELLING OF NBS TO ENHANCE THE RESILIENCE OF MEDITERRANEAN AGRO-SILVO-PASTORAL ECOSYSTEMS AND LANDSCAPES (DRYAD) (DRYAD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: Spain,Netherlands,Portugal,Italy,Greece,France
Call: Testing and demonstrating transformative solutions increasing climate resilience of the agriculture and/or forestry sector. (HORIZON-MISS-2023-CLIMA-01, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 8622807.5
EU funding (EUR): 8448545.0
Participants: 27
Project status: SIGNED

Mediterranean agrosilvopastoral ecosystems (MAEs), such as Dehesa in Spain, Montado in Portugal, Meriagos in Italy, & Valonian oak forests in Greece, provide essential environmental services and influence significantly local communities and their economies. MAEs are expected to be severely affected by climate impacts and extreme conditions such as droughts, high tree mortality and wildfires. Addressing these challenges, requires supporting local communities and authorities with local solutions and transformations towards climate-resilience. This DRYAD proposal supports the Mission Adaptation to Climate Change by developing and implementing real-life, climate-resilient nature-based solutions (NBS) for MAEs. DRYAD combines front-line scientific, technological, social, and business innovations as well as transformative solutions. The proposal will be centered around development, testing and demonstrating NBSs in 5 demonstration regions including Andalusia and Extremadura (ES), Alentejo (PT), Sardinia (IT) and Aetoloakarnania (EL) (5 in Cohesion Fund Regions). The most promising NBSs will be transferred to these 3 replicating regions: Castilla-y-León (ES), Occitanie (FR) and Tuscany (IT). Furthermore, DRYAD will support a multi-level and cross-sectoral integrated and adaptive management governance via development of Decision Support Systems. DRYAD will mobilize regional and local authorities and stakeholders that own the climate challenge, research entities, private/public foundations, companies & citizens and involve them in co-creation, co-implementation, and co-validation processes by means of Living Labs. This will lead to the creation of real, widely re-applicable solutions with long-lasting impacts. The project will provide tools and implementation guidelines to promote sustainable and climate-resilient practices and facilitate regional adaptation plans, contributing to the Nature Restoration Law in terms of resilient nature and climate adaptations.

Keywords: multirisk,integrated ecohydrological model,lorawan real time monitoring,climate resilience,nbs,
Space, domesTic and industriAl applications with impRoved TheRmoElectric Components (STARTREC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: France,Germany,Netherlands,Austria,Belgium
Call: Increasing the efficiency of innovative static energy conversion devices for electricity and heat/cold generation (HORIZON-CL5-2023-D3-03, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 2972802.75
EU funding (EUR): 2972802.75
Participants: 8
Project status: SIGNED

In the context of the energy transition, the interest for thermoelectric generators (TEG) is increasing, as they are able to tap into renewable or waste heat sources with very low impact. So far, wide-scale applicability of TE devices was limited by their low conversion efficiency, typically 5% at system level at the most. STARTREC will develop and evaluate a new generation of TEG based on the optimal combination of nanostructured Si85Ge15 thermoelectric materials with innovative device architectures designed by simulation: 1) Three different materials processing routes using nanostructuration to increase material performances: Additive Manufacturing (AM); Nanostructured Rapid Casting (Nano-RC); Optimized Rapid Casting (O-RC); 2) Innovative device architectures, such as complex forms and cascade architectures, which can considerably improve both their performance and their optimal temperature ranges, and so increase their efficiencies and potential for wider applications. STARTREC aims at doubling TEG efficiencies up to 10% at system level (15% at device level). It will demonstrate their high-performances in relevant environments at TRL5 for three different and complementary high impact use cases (industrial, domestic and space). Technical work will be completed by dedicated life cycle studies to address economic and environmental issues for these TEGs. A strong dissemination and exploitation strategy and novel circular business models will allow the developed solution to open new application opportunities in other sectors. With TEGs produced and commercialized by European industrial leaders, reinforcing EU strategic autonomy in renewable energy technologies, STARTREC has a complete value-chain with two RTOs, two universities, one technological SME and three industrial end-users. STARTREC will serve a global TEG market valued at 447.1 million € in 2020 and forecasted to reach 1365.8 million € by 2030.

Keywords: thermoelectric generators,energy conversion efficiency,sige,nanostructuration,optimized design,additive manufacturing,rapid casting,waste heat harvesting,simulation models
Homeoproteins as novel therapies for neurodegenerative diseases (HOMEOBRAIN)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 5523750.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

With the ageing of the population, neurodegenerative diseases will be a huge societal, health and economic problem. There are no effective solutions that can stop the progression of these devastating diseases. At BrainEver we are developing a groundbreaking platform to treat neurodegenerative diseases based on a family of transcription factors called Homeoproteins (HPs). Homeoproteins are endogenous proteins expressed in diverse neuronal types, where they regulate age-dependent mechanisms related to neurodegeneration. When homeoproteins are injected into the central nervous system of animals with disease, neuronal survival and function is restored, halting degeneration. This suggests a huge potential as therapies for neurodegenerative diseases. In this project, we aim to develop and clinically validate a revolutionary therapy using the homeoprotein Engrailed-1, to treat patients with Amyotrophic Lateral Sclerosis (ALS) and Parkinson’s Disease (PD).

Keywords: amyotrophic lateral sclerosis,parkinson s,homeodomain proteins,epigenetics,motor neuron disease,gene therapy