Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Accurate Intravenous Therapy for Every Patient (AITEP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Finland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Intravenous (IV) therapy involves administration of fluids or medications through a needle or a catheter and it is administered to over 90% of hospitalised patients. Although a simple procedure, a balanced IV therapy has a significant impact by reducing the number of complications by 59% and the length of hospital stay by 3.4 days. Currently the everyday IV treatment is administered manually and monitored visually as the infusion pumps that offer accurate treatment monitoring are very expensive and complicated to use, making them suitable only for emergencies. A Finnish SME, Monidor, has developed high-accuracy IV infusion monitoring device based on patented technology that uses infra-red light beam drop calculation and specific measurement algorithms. This allows to offer state-of-the-art accuracy in a simple and cost effective form bringing balanced IV therapy to every bed in the hospital. Additional features such as touch-screen interface and wireless connectivity will help to lower the associated workload for the medical staff. Monidor has been developing the technology for the past two years and has reached a prototype device currently defined at TRL7. The technological excellence has been tested with Oulu University Hospital and user needs studies have been conducted with medical staff in Finland, UK, Italy and Denmark. The company has a strong team of 8 experts including doctors and engineers with experience in R&D and business development from companies such as Nokia, Microsoft and Broadcom. Monidor is now looking to conduct the feasibility studies in order to finalize the development process and introduce the novel solution to the market. As a result of the proposed project Monidor will have a validated technology development plan, IPR strategy for EU-wide technology exploitation and a detailed business plan to commercialize the technology. According to the first estimates the company has the potential to generate revenues of more than 30MEUR by 2022.

Keywords: internet of things,monitoring,analytics,wireless technologies
Evolution and function of the germline-restricted chromosome in songbirds (birdGRC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2022-10-31
Duration (months): 22.0
Total project cost (EUR): 203852.79
EU funding (EUR): 203852.16
Participants: 2
Project status: CLOSED

Metazoans typically keep the same genetic information in all body cells over their life cycle. However, some organisms show exceptions to this rule through programmed DNA elimination from the somatic cell line, as it is the case of the puzzling germline-restricted chromosome (GRC) in songbirds. Recently, it has been demonstrated that the GRC is likely present in over half of all bird species and that the zebra finch GRC is enriched in developmental genes. The latter constitutes a novel mechanism for germline-specific gene expression in multicellular organisms, which is of significant relevance to fields as genomics, developmental biology, ecology or even cancer research. However, it remains mysterious how the GRC affects differential gene expression between tissues, the genomic divergence between species, and the determination of cell fate between germline and soma. To elucidate this, we will first perform multiplatform sequencing and high-quality assembly of the GRC in the zebra finch. Then, by comparing somatic and germline genomes from many bird species to infer the evolutionary trajectories of the GRC, we will determine its most ancient and, therefore, important genes. Finally, we will perform a functional analysis to elucidate the role of these genes in primordial germ cells and the early transmission in embryos. Recent technological advances in sequencing, bioinformatics and developmental biology provide us now with a unique moment to perform the proposed multi-omics analyses. Successful and high-quality implementation will be ensured by the extensive experience of the fellow in cytogenetics and genomics of supernumerary chromosomes as well as in developmental biology in zebrafish. In addition, the host lab is expert in cutting-edge multiplatform genomics techniques and has a multidisciplinary network of collaborators, and the secondment partner is expert in experimental biology with zebra finch embryos and primordial germ cell cultures.

Keywords: programmed dna elimination,zebra finch,germline restricted chromosome,cytogenomics,single molecule sequencing
International Energy Agency Joint Work Programme with the Kingdom of Morocco to support the transition away from to a decarbonized energy system. (Morocco)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Robust decision making and public engagement
Action type: Coordination and support actions
Countries involved: France
Call: Contribution to the International Energy Agency (IEA) (H2020-IBA-SC3-IEA-2017-2, 2017)
Start date: 2018-11-01
End date: 2021-06-30
Duration (months): 32.0
Total project cost (EUR): 136350.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The proposed Action will support analytical work carried out in the context of the IEA-Morocco Joint Work Programme (JWP). Under the JWP, which came into effect on 28 June 2017, the IEA will provide technical support and advice to assist Morocco in developing a strategy to design an integrated assessment of long-term low carbon energy transition pathways. The IEA-Morocco work programme will include capacity building and training in data and statistics; modelling and support for the de-carbonisation programme. The IEA will also provide advice on further energy price liberalisation and energy security in the oil, gas and electricity sectors. It will also advise the Moroccan Ministry of Energy, Mines and Sustainable Development (MEMDD) and related stakeholders on optimal technologies and best practices that can be implemented to help Morocco attain its Energy Efficiency and Renewable Energy targets. It is anticipated that EU support will cover the Energy Efficiency and Renewable Energy work streams outlined in the JWP. In addition to on-site visits, IEA experts will host interactive webinars in English with Moroccan energy efficiency stakeholders on mutually agreed priority areas. The IEA could also assist MEMDD and the Moroccan Agency for Energy Efficiency (AMEE) in assessing the economic and other conditions for a push towards clean, electric cooking. The main purpose of this activity would be to ensure that energy efficiency measures are accelerated and run parallel with renewable energy deployment. This proposal relates to item 57 in the Horizon 2020 Work Programme for 2016-2017. This action will be instrumental in supporting Morocco’s transition to a reliable, sustainable and competitive energy system, in particular in Horizon 2020 priority areas such as reduction in energy consumption and carbon footprint; generation and transmission of lower-cost, low-carbon electricity; new knowledge and technologies;

Keywords: iea morocco joint work programme
Non-linear temporal dynamics of mutually inhibiting pyramidal cells: underlying mechanism for bi-stable perception and disambiguation (M-INHIB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2020-06-30
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Bi-stable perception has been the key tool to investigate how retinal information reaches consciousness. In existing theoretical work to explain this phenomenon, it has been assumed that a neural circuit, called mutual inhibition, plays the key role in perceptual alternations. Two neurons (or neuron groups) representing competing percepts inhibit each other and one becomes dominant while another becomes suppressed. Adaptation of the dominant neuron and recovery of suppressed neuron causes the reversal of the dominance after few seconds. While there are elaborate theoretical models implementing this circuit, its physiological data from real neurons is missing. I will use in vitro preparation combined with a state-of-art “dynamic clamp” system where the disynaptic inhibitory connections between two real pyramidal cells are established by model synapses and inhibitory neuron models. I will run paradigms equivalent to experimental paradigms known in the research of bi-stable perception. In this way, I aim at elucidating the neurophysiological factors underlying the known dynamical properties of bi-stable perception. I will investigate how dominance durations and their distributions are influenced by the activity levels of the two neurons (equivalent to the well-known Levelt’s propositions), how their stochasticity is influenced by noise, how memory effect can be observed, and how feedback projection influences their dynamics. There is often an ambiguity in input images due to noise or conflicting information. Coherent representation of such input can be established if the mutually inhibiting neurons representing conflicting cues are influenced by feedback such that the neural signals consistent with global properties are enhanced. Therefore, mutual inhibition may work as a fundamental unit of signal processing in establishing coherent perception. This project will elucidate this essential mechanism underlying perceptual organization.

Keywords: perceptual organization,vision science,in vitro patch clamp recording,neuro computational model,stochastic neural activities and noise,short term plasticity
Diversification and Economic Resilience of Iran (DIVERSIRAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2024-06-28
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

The research project ‘DIVERSIRAN – DIVersification and Economic ReSilience of IRAN’ studies the factors that have shaped Iran's strategies for economic diversification and resilience. Economic diversification in this study is not limited to the traditional definition (i.e. the state’s strategy of diversifying economic activities from the hydrocarbon sector). Instead, it looks for factors shaping the diversification of the economy beyond the country’s borders and their implications on trade and economic partnerships. The project captures all factors that contribute towards shaping development, resilience, and diversification strategies of the Iranian economy. It provides a multifaceted analysis of the impacts of domestic political dynamics, institutional capacity, the military-political-business complex, sanctions, and regional and international affairs on Iran’s economic strategies. By providing a deeper understanding of the current economic mindset and policy implications in Iran, the research applies a forward-looking approach in assessing the long-term impact on the future socioeconomic stability of the country. The project adopts an interdisciplinary mixed-method approach by merging elements of political science, international relations, economics, and development studies. It combines qualitative content analysis of secondary data available in Farsi, English, and Arabic and process tracing in order to assess the causal relationship between factors shaping economic strategies, policy implications, and the long-term socioeconomic impacts in Iran.

Keywords: iran,economic diversification,sanctions,middle east
Evolution of the Non-Uniformitarian Earth (NONUNE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany,Switzerland,United Kingdom,United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 3495978.0
EU funding (EUR): 2050548.5
Participants: 5
Project status: SIGNED

The project will use a set of innovative techniques to study the two major events that precede classical, uniformitarian geology. We will search for crystallised remnants of the primordial terrestrial magma ocean and examine the consequences of our observations for mantle dynamics. Crystallisation of the dominant lower mantle phase, bridgmanite, imparts a Mg and Si isotopic fingerprint to cumulates and evolving liquid of the magma ocean. Identifying the relicts of these small but distinctive fractionations requires application of our bespoke, high precision analytical protocols. As an integral part of this work, we will undertake coupled first principles calculations and petrological experiments to provide a benchmark documentation of the isotopic fractionations experienced by these two most abundant cation-forming elements in the silicate Earth. We will also date the global onset of plate tectonics from complementary geochemical signatures in two little-studied detrital minerals; Pb enrichment in continental K-feldspars and Mo depletion in rutiles from exhumed fragments of subducted crust. This work uses ground-breaking methodologies made possible by our unique, tribrid (mass-filter:collision-cell:multicollector) mass-spectrometer, Proteus. We will further develop this technology in collaboration with Thermo Fisher to produce a yet more capable next generation instrument. Our tribrid mass-spectrometer allows us to date single, detrital K-feldspars by laser ablation, using Rb-Sr internal isochrons constructed with analyses of host feldspar and sodic perthite exsolutions. Coupled with in situ Pb isotope analysis, we can calculate the U/Pb of the feldspar’s crustal protolith, which diagnostically tracks contributions from subduction.

Keywords: isotopic fractionation,mantle convection,magma ocean,continental growth
Cancer biOengineered Novel microTissues unrAveling Cancer plasTicity (CONTACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-15
End date: 2023-01-14
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

Triple Negative Breast Cancer is the most aggressive among breast cancer subtypes. The conventional neo-adjuvant therapy is ineffective in about 50% of cases, with patients presenting a higher risk of recurrence and metastasis. The failure of the currently available chemotherapeutic strategy is also due to the lack of cancer preclinical models that are “close-to-reality” and therefore able to accurately recapitulate the tumor microenvironment, the transcriptional reprogramming and the cancer cells plasticity of patients with poor outcomes. Currently, miRNAs and lncRNAs are believed to be key components in all major adaptation pathways and involved in the transcriptional reprogramming that occurs after TNBC treatment with neo-adjuvant therapy. Moreover, bioengineered preclinical in vitro models permit to study the molecular mechanisms underpinning adaptive responses to chemotherapy by selecting transcriptional phenotypes that somehow make tumor cells tolerant to drugs, without requiring a selection of genetic features. The CONTACT project aims at developing a 3D bioengineered TNBC in vitro model able to shed light on the mechanisms of tumor cells reprogramming that trigger drug-tolerance. The model will include stromal components along with cancer cells and represent an important tool in studying the role of the stroma in transcriptional reprogramming. Bioengineered 3D breast cancer in vitro models will accelerate the establishment of personalized treatment protocols that take into account what exactly, in each patient, leads to transcriptional reprogramming. The CONTACT project will boost the scientific career of the experienced researcher and will lead her to an independent role in research. The project will also broad the expertise of the experienced researcher in the area of cancer genomics. Her expertise in 3D tumor models will pave the way for a new research line in the scientific portfolio of the host institution.

Keywords: triple negative breast ca,spheroids,3d cultures,drug response and,or resistance,microenvironment,extracellular matrix,ecm,stroma
Grid Integrated Multi Megawatt High Pressure Alkaline Electrolysers for Energy Applications (ELYntegration)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Public-private partnerships
Destination: Fuel Cells and Hydrogen
Action type: Research and Innovation actions
Partnership: FCH2 (Art-187)
Countries involved: Germany,Spain,Germany,Spain,Belgium,Switzerland
Call: Improvement of electrolyser design for grid integration (H2020-JTI-FCH-2014-1, 2014)
Start date: 2015-09-01
End date: 2019-05-31
Duration (months): 45.0
Total project cost (EUR): 3301391.25
EU funding (EUR): 1861309.0
Participants: 6
Project status: CLOSED

The strategic goal of the ELYntegration Project is the design and engineering of a robust, flexible, efficient and cost-competitive single stack Multimegawatt High Pressure Alkaline Water Electrolysis of 4,5 T H2/day capable to provide cutting-edge operational capabilities under highly dynamic power supplies expected in the frame of generation/ transmission/ distribution scenarios integrating high renewable energies (RE) shares. The final design of the MW HP AWE will be achieved on the basis of the development, validation and demonstration of a HP AWE industrial prototype of 250 kW (250 HP AWE) (TRL 7) comprising: - cylindrical stack consisting of industrial size elementary cells (1,600 mm cell diameter) - balance of plant (BOP) - power electronics - advanced communication & control system In the early phase of the development process, great attention will be brought to the identification of end-user’s needs and relevant/critical operational requirements. The target behaviour of the industrial prototype will be thoroughly demonstrated in an operational environment reflecting different on-grid integration schemes using power facilities already available to the Consortium (notably, 635 kW wind and 100 kW photovoltaic power plants). As previously mentioned, the successful demonstration of the industrial prototype will be paving the way towards the implementation and the commercial deployment of the 4.5 T H2/day HP AWE technology in the frame of large scale demonstration projects which shall be the next step after the conclusion of ELYntegration.

Keywords: multi megawatt high pressure alkaline electrolysers,business models,stack improvements,cost reduction,manufacturing process
Network for sOcial compuTing REsearch (NOTRE) (NOTRE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Spain,Cyprus,Switzerland,Greece
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 6
Project status: CLOSED

The vision of NOTRE is to develop a network that will strengthen and enhance the potential of the newly established Social Computing Research Centre (SCRC) at the Cyprus University of Technology (CUT) for stimulating scientific excellence and innovation capacity in the area of social aspects of computing. NOTRE proposes an interdisciplinary approach towards the close network collaboration between SCRC of CUT, a research active university in a low-performing member state, and four internationally-leading counterparts specializing in: (a) online social networks and their analysis; (b) entertainment, games, virtual reality and educational technologies; (c) Social Computing for social inclusion; and (d) Social Computing and social change. SCRC through this proposal does not only aim to access the core research groups of the leading counterparts, and their collaborators, but also recognizes the multidisciplinarity of the field and will try to establish itself as an intermediate between them. The NOTRE network will follow a series of interlinked activities, such as short term staff exchanges, expert visits and short-term on-site training, workshops, conference attendance, organization of joint summer school type activities, and dissemination and outreach activities. Such activities with world-renowned EU partners (IMDEA; MIRALab of Universite de Geneve; Institute of Computer Science of the Foundation for Research and Technology Hellas -FORTH-ICS; and the Department of Political Science of the University of Dusseldorf -UDUS), will be instrumental for significantly strengthening SCRC's research efforts, enhancing the network's innovation capacity and research profile, and stimulating scientific excellence in the emerging multidisciplinary field of Social Computing. The effective knowledge transfer and sharing through NOTRE will also push for research advancements linked to the Smart Specialization Strategy of Cyprus.

Keywords: social computing,social inclusion,social exclusion,social network analysis,social games