Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The detection of boundary changes as a method for early diagnosis of cardiovascular disease (CARDIO-DETECT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-10-12
End date: 2011-10-11
Duration (months): 24.0
Total project cost (EUR): 172051.79
EU funding (EUR): 172051.79
Participants: 1
Project status: CLOSED

Current clinically approved methods for detection of Cardiovascular Disease have a number of associated disadvantages and limitations. All methods have some reliability issues and most are based on detection of plaque. Once plaque already exists however, disease may have been getting progressively worse for decades. Methods based on detection of plaque are therefore not able to detect the disease in the early stages. Better diagnostic methods, especially for early detection, are therefore urgently needed and will provide a great improvement on existing methods. A major problem in establishing better diagnostic methods is the large scientific gap which exists between clinicians and scientists, making communication extremely difficult. This proposal will use the unique skill-set of Russian scientist with formidable clinical knowledge and the highest level of mathematical and computational skills to transfer clinical knowledge to the scientific community. This proposal will use this unique skill-set to establish the necessary scientific basis to pursue new methods to detect cardiovascular disease earlier and more reliably than presently possible. The essence of the approach is that material changes must occur at the inner boundary of the artery in the very earliest stages of disease. This novel approach will use advanced asymptotic long wave methods developed by the UK host and will determine changes at the inner boundary through changes to the expected dispersion spectrum. The results from this project will provide the urgently required framework to supply a scientific benchmark, enabling new diagnostic equipment to be developed; this will not only save and improve quality of life, it will significantly reduce the financial cost of treatment and long term care of cardiovascular disease.

Keywords: engineering mathematics,biomathematics,cardiology,biomedical engineering
Irrigation and Society: "levadas da Madeira" (LEVADAS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-09-01
End date: 2011-08-31
Duration (months): 24.0
Total project cost (EUR): 128611.32
EU funding (EUR): 128611.32
Participants: 1
Project status: CLOSED

Overall objective: The present project aims at analyzing the historical construction and development of irrigations systems by a society. It emphasizes the role of technology and institutions for construction, water management and control. The research examines how irrigation organization has been crafted over the time, until today and how the present governance system reflects historical transformations within the society and its segments. Addressing the relations of a particular society to irrigation the project contributes to enlarge the existing knowledge of these relationships in different world contexts. The context of the project is the island of Madeira in relation to its fragile resource: The set of ancient and modern systems of canal irrigation called “levadas”, is the main scene where this research has to be implemented. The network of irrigation channels is impressive. Through the Mediterranean, there is no situation where exists such density of watercourses. Madeira provides an ideal position to interrogate universal social theories in irrigation, while at the same time contributing to the regional history and anthropology of irrigation agriculture. The project fixes as milestones the following goals: a) The production of a technological geography of irrigation systems b) An interpretive anthropological study of selected irrigation systems c) An interpretation of the modern water governance d) In addition a portrait of some of the irrigation cultural patterns of Madeira society. These objectives will be achieved by means of an innovative strategy to investigate irrigation technology and institutions in ‘their context’. Results: Assessment of social history and organisation of Madeira irrigation will be produced. In addition, the research project through the diffusion of its results may participate to water debate in Madeira. The project by its multidisciplinary approach contributes to scientific excellence expected in Marie Curie actions

Keywords: social sciences,natural sciences,technological sciences
Micro-dynamics of rebellions: An inquiry into the role of middle level commanders in Chad (MICROREB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IOF-2008, 2008)
Start date: 2009-08-01
End date: 2012-07-31
Duration (months): 36.0
Total project cost (EUR): 222179.59
EU funding (EUR): 222179.59
Participants: 1
Project status: CLOSED

This research seeks to extend the literature on the micro-dynamics of civil wars by focusing on a little-studied issue: the role of middle level commanders in unstable armed groups. How do they broker and shape the relationships of politico-military leaders and grassroots combatants? Our contention is that middle level commanders play a crucial role in shaping rebel groups’ profile and conduct even if they do not dictate the movement’s political agenda. This research will be conducted in Eastern Chad where armed groups have proliferated since the 1970s. Drawing on her past experience of fieldwork in this region, the fellow will carry out her research with a qualitative method. The analysis, which will provide a historically and socially grounded understanding of rebel hierarchy in Chad, seeks to open up a new set of questions on a conflict which has not received adequate attention. In addition to a contribution to the extant literature on armed conflicts, this research will deliver timely, policy-relevant findings at a crucial point when the European Union has deployed its biggest peace keeping mission in Chad. The fellowship is crucial to the project as it will allow the fellow to diversify her research profile by collaborating with internationally leading scholars at Berkeley; implement the acquired training in innovative research at the return host institution in France; and enhance her competitiveness in the male-dominated fields of African studies and conflict studies.

Keywords: anthropology,political sciences,armed conflicts,violence,africa,chad,darfur,peacekeeping,european security and defence policy
New metal catalised C–H bond activation strategies for chemical synthesis (CHACTSCS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-04-01
End date: 2011-09-30
Duration (months): 18.0
Total project cost (EUR): 129325.98
EU funding (EUR): 129325.98
Participants: 1
Project status: CLOSED

The capacity to selectively functionalise either small molecules or more complex structures represents a persistent and ever increasing challenge in chemical synthesis. Transition metal catalysed coupling reactions have offered a revolutionary solution to the problem of selective derivatisation that has transformed the way we do synthesis over the last 30 years. However, while these precise reactions almost always proceed as planned this is because you ‘pay up front’ for selectivity by using pre-functionalised building blocks (which of course have to be synthesised selectively themselves). This problem has been partly overcome because of the vast number of small specifically functionalised building blocks that are now available from commercial sources. However, in more complex systems it is not always possible and indeed becomes increasingly more complicated to carry orthogonally reactive motifs through a synthesis in order to exploit further conventional coupling tactics at a later stage. Therefore, the development of new methods for the selective controllable functionalisation of small and/or complex molecules is still a pivotal aspect of modern chemical synthesis. One of the major research theme’s in our research group is a programme dedicated to the development of new reactivity concepts that enable the design of metal catalysed C–H bond functionalisation strategies. Of particular importance in our design blueprint for these new C–H bond functionalisation concepts is (i) controllable and flexible regioselectivity of the new reactions, (ii) mild and facile reaction conditions and (iii) substrate generality. In order to achieve this we try to develop new chemical reactivity principles as part of our catalytic strategies.

Keywords: carbon chemistry,organic synthesis,homogeneous catalysis,atom economy,ch-activation,transition metal,heterocycle,chemical biology,oncology,autoimmune disease
Supramolecular Medicine: Modular, Double Dynamic and Orthogonal Functionalization of Supramolecular Biomaterials (SUPMED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-03-01
End date: 2011-02-28
Duration (months): 24.0
Total project cost (EUR): 168291.38
EU funding (EUR): 168291.38
Participants: 1
Project status: CLOSED

The main objective of this project is to create a new generation of smart biomaterials with great potential for tissue engineering and controlled drug delivery. Supramolecular polymers based on quadruple hydrogen bonding ureido-pyrimidinone (UPy) moieties (developed by the host group of Prof. Dr. E. W. Meijer in Eindhoven University of Technology, the Netherlands) will be employed as a basic scaffold. To fulfill the biomaterials trinity, namely tuneable mechanical properties, biodegradability and bioactivity, we propose a unique approach to functionalize the biomaterial scaffold in order to generate biomedical activity. The combination of dynamic covalent chemistry (developed by the group of Prof. Dr. Jean-Marie Lehn in Louis Pasteur University, France where the applicant comes from) and non-covalent UPy-UPy hydrogen bonding allows for a modular (self-assembly) and orthogonal (self-sorting) approach to control cellular behaviour and activity both in vitro and in vivo. Due to their dynamic characters on both non-covalent and reversible covalent levels, they can be considered as constitutional double dynamic biomaterials, capable of response to different external stimuli (pH, temperature etc.), thus behaving as adaptive biomaterials. The results that will emerge from the current proposal are of particular interest for the fields of regenerative medicine and controlled drug delivery, which have a remarkable impact in human health care. This project will initiate the first cooperation between the host group and the group the applicant comes from, to tackle a major challenge for chemical biologists. Hence, it will contribute to European research and transfer of knowledge.

Keywords: supramolecular chemistry,macromolecular chemistry,polymer chemistry,biomedical materials,tissue engineering,nanobiotechnology
Exploring diapycnal mixing in the Southern Ocean (MIXCLIM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-03-01
End date: 2009-09-30
Duration (months): 7.0
Total project cost (EUR): 171300.62
EU funding (EUR): 171300.62
Participants: 1
Project status: CLOSED

Because they control the rate at which water sinking at high latitudes returns to the surface in the Southern Ocean, mixing processes govern the capacity of the Southern Ocean to take up CO2 and the sensitivity of the Meridional Overturning Circulation (MOC) to climate change. Mixing processes also play a key role in the formation and meridional transport of Southern Ocean mode and intermediate waters. Recent in situ estimates of turbulent mixing indicate remarkably intense and widespread turbulent kinetic energy dissipation in four Southern Ocean “hotspots”. Three different mixing processes (breaking of internal waves generated by tidal, mean or atmospheric-depression induced flow interacting with topography) are suspected to generate diabatic mixing, but their relative contributions both in terms of their magnitude and distribution in the vertical remain unclear. Furthermore, these processes are not taken into account in climate and ocean circulation models. The aim of the present project is thus to quantify the main different diabatic mixing processes in the Southern Ocean interior and to parameterise their effects within ocean models. Simple consideration of linear wave propagation and dissipation of internal waves in a stratified fluid will be used to create specific parameterisations of the missing physics in an eddy resolving model focussed around the Kerguelen Plateau.The parameterisations will be tested and refined by the comparison of model data with ARGO float data. The respective contributions of the three different mixing processes will be quantified and introduced in a global ocean circulation model in order to assess their impact on the MOC and CO2 uptake. This modelling study is very timely since it would benefit and complement observations planned by NOCS: the SOFINE project that will measure vertical diffusivity in the Kerguelen region and the DIMES cruises that will measure isopycnal and diapycnal mixing in the Drake Passage and the Scotia Sea

Keywords: physical oceanography,southern ocean,diapycnal mixing,modelling,parameterization
Rapid functional characterization of ion channels with droplet interface bilayers (DIB SCREENING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-06-01
End date: 2012-05-31
Duration (months): 24.0
Total project cost (EUR): 180783.75
EU funding (EUR): 180783.75
Participants: 1
Project status: CLOSED

Of the estimated 400 ion channels encoded in the human genome, ~70 are potassium (K+) channels. Their implication in a number of human diseases, e.g., cardiac arrhythmia, cystic fibrosis, makes K+ channels relevant drug targets. Whereas the number of high-resolution structures of membrane proteins has consistently increased over the last few years, their functional characterization using screening approaches has not kept pace with that of water-soluble proteins. In this context, reliable and informative rapid screening assays for membrane proteins are needed. By further developing the recently reported droplet interface bilayer (DIB) system, I intend to develop a rapid automatable platform for screening wild-type channels as well as libraries of mutant ion channels using Kcv (viral), KvAP (prokaryotic) and Kv1.2 (eukaryotic) as model systems. My blueprint for such a screening device is analogous to an assembly line consisting of a network of microchannels to; (i) construct lipid monolayer-encased aqueous droplets, (ii) synthesize ion channels inside these nanobioreactors by coupled in vitro transcription-translation (IVTT), (iii) form bilayers with other droplets containing channel blockers, (iv) subsequently measure single-channel conductance to determine activity. The assay will be capable of screening one channel against hundreds of blockers or screen a library of mutants against one or a few blockers. The development of this nanoscale-streamlined process offers the possibility of producing powerful lab-on-chip instruments for membrane protein assays, which have previously proven intractable.

Keywords: droplet interface bilayer,medicinal chemistry,membrane protein,single-channel recording,single-molecule chemistry
Intake Flow Simulation and Optimisation for Hydropower (IFLOW)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-06-01
End date: 2011-05-31
Duration (months): 24.0
Total project cost (EUR): 168717.32
EU funding (EUR): 168717.32
Participants: 1
Project status: CLOSED

The flow simulation and optimization in terms of the efficient water power utilization is the essential topic of the proposal. The main goals of the submitted project are: - To identify the negative influence of ill-designed intake structures at run-off river power plants on the water turbine efficiency and the rotor vibrations; - To find and prove the methodology of intake structure geometry optimization by means of the numerical flow simulation and the physical modelling, and to reach the best conditions for maximal turbine efficiency and its output. The project combines civil hydraulic engineering with mechanical hydraulic engineering. Turbine producers focus on the design of a runner and adjacent water passage, whereas civil engineers concentrate on a broader area of free surface. The project is going to solve the complex intake flow interdisciplinary concerning the entire intake section configuration. The fellow will thus utilize his recent expertise in both fields and to help bridging the existing gap between both civil and mechanical engineering. Undertaking of the project will also enable the fellow to acquire the better familiarity with CFD simulation methods and their implementation into hydropower and to deepen many other complementary skills. The excellent computation accessories of the host organization will be used for flow simulations. The computed results will be verified on a physical test model in the Hydraulic laboratory at the host institution too. Modern disturbance-free laser anemometry will be applied for measurements at physical model. Regarding the support of power renewable resources, the resolved problems are very current nowadays. There are lots of refurbishments of outdated low head run-off river power plants in order to increase higher efficiency of hydropower generation. That’s why it is important to deal with a question, to what extent the ill-shaped intake structures influence the turbine behaviour.

Keywords: technological sciences,hydraulic engineering,hydropower,numerical flow simulation,physical modelling
Gas Sensor NanoWires by Chemical Vapour Deposition (GASNOW)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-05-01
End date: 2012-04-30
Duration (months): 24.0
Total project cost (EUR): 210933.51
EU funding (EUR): 210933.51
Participants: 1
Project status: CLOSED

This proposal has two main aims: to perform high quality scientific and technological research, and to give training to an experienced researcher to establish her as an independent researcher. Scientific goals Fabrication of nanostructured WO3 as Gas Sensor material using Chemical Vapour Deposition WO3 is one of the most used materials for gas sensing, due to its sensitivity and stability. However, it does not show a very good selectivity, and the fabrication process is often long and expensive. This project investigates the improvement of the selectivity and sensitivity of WO3 by depositing it as nanowires. To perform this, the use of a hybrid (combined) Atmospheric Pressure and Aerosol Assisted Chemical Vapour Deposition (AP/AACVD) is proposed; this technique is very cheap, simple and could be easily industrialised. The modification of WO3 will be also investigated: noble metal nanoparticles (i.e. Au, Ag, Pt) and Carbon NanoTubes (CNT) will be used to modify the gas sensor surface. In this way the selectivity of the sensor is greatly improved. The main scientific/technological outcome of the project will be the fabrication of prototype gas sensor devices, achieved by performing the deposition on appropriate gas sensors substrates, such as alumina and micro-hot-plate. Training goals The training given to the researcher will consist of both scientific and transferable skills. Scientifically, she will gain knowledge in Materials Science (experience in gas sensors materials) and Electric Engineering (instruments and devices). The latter one is particularly important for her, considering her Chemistry/Materials Science background – she will broaden her skills and expertise. Regarding transferable skills, she will be mentored by the scientist in charge in tasks such as research proposal writing, student supervision, and project management and coordination. All these activities will help her to improve her profile and establish her as an independent researcher.

Keywords: gas sensors,chemical vapour deposition,nanowires,materials engineering,nanotechnology