Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Integrative MSCA Achievements and Networks for Unified Strategies (IANUS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: MSCA other
Action type: Coordination and support actions
Countries involved: Norway,Italy,Croatia,Germany,Belgium
Call: MSCA Feedback To Policy 2024 (HORIZON-MSCA-2024-FTP-01, 2024)
Start date: 2025-04-01
End date: 2028-03-31
Duration (months): 36.0
Total project cost (EUR): 1798215.98
EU funding (EUR): 1798215.98
Participants: 7
Project status: SIGNED

IANUS aims to maximize the strategic impact of the Marie Skłodowska-Curie Actions (MSCA) on the European Union's Missions and the European Research Area (ERA). The project will conduct a large-scale portfolio analysis of all projects funded under Horizon 2020 and Horizon Europe, using advanced computational methods to uncover features and patterns across projects that are not identifiable through standard analytical approaches. This analysis will identify thematic clusters, particularly those related to the EU Missions, and estimate the contribution of MSCA projects to these missions. Additionally, the portfolio analysis will explore the evolution of research themes and emerging trends over time, tracking the most significant trajectories. Building on this analysis, the project will develop pilots for the two largest EU Missions: Mission 2 (Cancer) and Mission 4 (Smart Cities). It will identify projects suitable for survey analysis and pilot in-depth case studies to uncover good practices, success stories, obstacles, and solutions in MSCA projects, particularly regarding researchers' intersectoral cooperation, training, skills development, and ability to address societal challenges, including those covered by the EU Missions. An agent-based model, co-designed with stakeholders, will simulate the large-scale effects of scientists' bottom-up adaptive responses to potential policy interventions in artificial simulation scenarios. Finally, the results will form the backbone of policy development workshops and events with stakeholders, aimed at developing recommendations to enhance the policy impact of the MSCA, the exploitation of MSCA project results, intersectoral cooperation, and researchers' skills and career development. Through extensive stakeholder engagement and the dissemination of results, the project will ensure broad impact and the sustainability of its outcomes.

Keywords: msca marie sk odowska curie actions,eu missions,portfolio analysis,intersectoral cooperation,policy feedback
Roles of cytoplasmic bridges in cell-cell cohesion and communication (CYTO-BRIDGES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

During development, cells divide and make fate decisions. Canonically, cell division ends with the severing of the link between daughter cells in the process called abscission. Yet, across the tree of life, cells can remain connected through cytoplasmic bridges by delaying or inhibiting abscission. Curiously, while bridges are important conserved structures sustaining cellular function, there are little evidence to explain how bridge impact cell function. The aim of the proposal is to investigate the hypothesis that bridges are conserved organelles critical for cell function by providing unique mechanical connexion and an important inter-cellular communication channel. In particular, we will leverage our expertise in live imaging of cell division and biophysics as well as a combination of newly developed genetic and optogenetic manipulations to determine: 1) The role of bridges as a mechanical coupling between connected cells. We will test the contribution of cytoplasmic bridges in creating a physical link between cells and the consequences of disturbing this cohesion for cell function. 2) The role of bridges as an exchange route between connected cells. We will investigate how the regulated exchange of cellular material through bridges impacts cell function. As bridges can have a simple or a complex structure that could be critical for their function, we will use 2 model systems: the choanoflagellate Salpingoeca rosetta where a structurally simple bridge sustains cell-cell cohesion, and mouse embryonic stem cells where bridges are structurally more complex. While traditional models of bridges are difficult to manipulate, both our models are easy to culture and provide an experimentally tractable system that can shuttle from a unicellular to a multicellular organisation. The comparison between these two model systems will allow us to understand how a fundamental step of cell division could crucially impact the function of cells in a multicellular context.
Innovative Algorithms for Applications on European Exascale Supercomputers (Inno4Scale)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Research and Innovation actions
Partnership: EUROHPC (JU-JTI)
Countries involved: Spain,Germany,Belgium
Call: New algorithms for applications on European exascale supercomputers (HORIZON-EUROHPC-JU-2022-ALG-02, 2022)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 4999999.5
EU funding (EUR): 4999999.5
Participants: 4
Project status: SIGNED

New architectures for Exascale and post-Exascale computers will have massively parallel and heterogeneous processing capabilities that will require the complete redesign and reimplementation of the used algorithms to fully exploit the possibilities of these supercomputers. The objective of the Inno4scale project is to promote the efficient use of European HPC systems by identifying and funding the most promising novel algorithms for applications. Through this action, the project will facilitate the design and development of highly efficient application software for European Exascale computers, the most successful of which should later be taken up by science and industry, resulting in important performance gains. The project will design and implement a call for proposals based on the cascade funding mechanism, financing the most promising ideas on novel algorithms for applications to fully exploit and benefit from these valuable European Exascale resources. Proposals received will be evaluated by external experts based on their potential innovation and impact on the upcoming Exascale era, and the CASTIEL/EuroCC2 and PRACE networks will be used to ensure the widest possible reach of the call. The Inno4scale consortium, made up of two major European HPC research centres and two experienced partners in managing HPC-related programmes, is in the ideal position to carry out the project in an effective and efficient manner. The results of the selected innovation studies that will receive more than 4 million euros in total, include the development and publication of the novel algorithms to reduce the time-to-solution or energy-to-solution of existing computing problems, as well as to provide novel approaches for large-scale projects. In this way, the Inno4scale project will contribute to the realisation of the EuroHPC JU overall objectives and those specific for this call, as well as enable an optimal exploitation of European Exascale and Post-Exascale HPC systems.

Keywords: exascale,algorithms,eurohpc,open call
The End STate of GRavitational collapse: black holes or else? (TESTGR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

General relativity (GR) is a very elegant theory from the conceptual point of view and a very successful one from the experimental side. However, there are several conceptual reasons, such as the singularity problem, that motivate the study of extensions of GR. The study of black hole physics will play a pivotal role in the understanding of new physics beyond general relativity. In fact, black holes hide in their interior theoretical evidence of the breakdown of GR and they are compact objects where strong gravity effects are nonnegligible. The research proposal "The End STate of GRavitational collapse: black holes or else? (TESTGR)" focuses on the study of several aspects associated with the black hole singularity problem looking for possible evidence of new physics beyond GR, to understand how the modifications would manifest and how to detect them. The proposed research comprises both theoretical and phenomenological studies. It is divided into 3 working packages (WPs) that are strongly interconnected but that can be studied independently. The first WP studies the mechanism leading to the formation of black holes mimickers. The second WP addresses crucial issues related to the viability and stability of the identified classes of spacetimes. Finally, the last WP focuses on the interplay with observations. This research proposal is particularly timing as the LIGO/VIRGO/KAGRA detectors, the EHT, as well as the next generation of earth and space-based interferometers, will collect plenty of data in future years. This leads to a growing necessity for theoretical studies beyond general relativity to understand if the data contains evidence of new physics that can revolutionize our understanding of nature.

Keywords: black holes singularities non singular spacetimes ultracompact objects beyond general relativity quantum gravity phenomenology event horizon telescope
Training the next-generation of European GLIOblastoma (translational) researchers, to RESOLVE precision targeting of the brain tumour microenvironment (GLIORESOLVE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Belgium,Netherlands,France,Luxembourg,Germany,Spain,United States,Norway,United Kingdom
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 2933189.14
EU funding (EUR): 2672925.6
Participants: 22
Project status: SIGNED

Isocitrate dehydrogenase wildtype (IDHwt) glioblastoma (GBM) is the most frequent, aggressive and lethal brain tumour. It has a universally fatal prognosis with 85% of patients dying within two years. Effective precision medicine therapies are thus urgently required. This can only be achieved by focused multi-sectoral collaborations in innovative research disciplines. Overall, GLIORESOLVE will exploit the intractability of GBM to address European applied biomedical research training needs and will train 10 innovative, entrepreneurial doctoral researchers (DRs). The research objectives of GLIORESOLVE are i) to extend immunotherapy options to IDHwt GBM patients and identify novel tumour microenvironment (TME) subtype-specific therapeutic targets, (ii) develop and optimise state of the art pre-clinical models that recapitulate GBM TME-subtypes and (iii) test novel rationally selected (available) drugs / drug combinations for precision treatment of IDHwt GBM based on TME subtype assignment. Cumulatively, the programme seeks to generate sufficient data to support a post-project Phase 2 clinical trial. The consortium brings together leading European academics, clinicians, private sector and not-for-profit partners, and incorporates disruptive research methods including multi-omics, ex-vivo ‘tumour-on-a-chip’ assay development, computational modelling and systems biology. Overall GLIORESOLVE provides a comprehensive translational research strategy that goes significantly beyond the current state-of-the-art in neuro-oncology, to establish a new TME-targeting precision medicine platform for this incurable disease. The GLIORESOLVE network addresses current needs in academia and the private sector to train doctoral researchers in an environment that spans multiple disciplines. Thus, GLIORESOLVE DRs will be able to navigate confidently between clinical, academic and private sector environments to progress applied research findings towards improved patient outcomes.

Keywords: glioblastoma,preclinical models
The Ultra-Low Frequency Universe (ULU)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 1996250.0
EU funding (EUR): 1996250.0
Participants: 1
Project status: SIGNED

The ULU project will explore the largest scales of our Universe mapping one of the last uncharted observational windows of the cosmic electromagnetic spectrum: the ultra-low radio frequencies (10-100 MHz). Although these frequencies are crucial to unveil the nature and evolution of galaxy clusters, the complexity of such observations prevented their exploitation until now. Techniques I developed to analyse Low Frequency Array (LOFAR) data were able to overcome this limitation. With ULU we will survey the northern sky producing ultra-low frequency images that are 100 times more sensitive than the state-of-the-art. The legacy of ULU will be long lasting with a far reaching scientific outcome: from galaxy evolution to ionospheric science, from exoplanet habitability to the detection of the first galaxies at cosmic dawn. Within the ULU project, I will combine the survey with my expertise on the study of galaxy clusters. My group will adopt an innovative approach based on unveiling the full picture of the cosmic ray (CR) life-cycle in the intracluster medium, effectively combining diverse topics historically studied independently, such as the growth of structures, AGN activity, and galaxy evolution. While conventional radio frequencies are sensitive to emission generated by highly energetic CRs, with ULU we will explore the far larger domain of low-energy CRs that can be accelerated by still unexplored microphysical mechanisms. Furthermore, their emission can be observed over Gyr time scales, revealing the long-term actions and interactions of radio sources in cluster environments. With a full picture of the CR life-cycle we will 1. unveil how cluster merger energy is deposited in the intracluster medium through shocks, turbulence and other mechanisms, 2. measure the long-term effect of AGN feedback up to the age of cluster formation, and 3. make a realistic attempt at the characterisation of the WHIM properties and constrain the origin of cosmological magnetic fields.

Keywords: radio astronomy,astronomical surveys,galaxy clusters
Governance innovations for a transition to sustainable and equitable water use in Europe (GOVAQUA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Research and Innovation actions
Countries involved: Finland,United Kingdom,Germany,Netherlands,Spain,France,Romania
Call: Water governance, economic and financial sustainability of water systems (HORIZON-CL6-2022-GOVERNANCE-01, 2022)
Start date: 2023-02-01
End date: 2027-01-31
Duration (months): 48.0
Total project cost (EUR): 3003645.0
EU funding (EUR): 3003645.0
Participants: 12
Project status: SIGNED

GOVAQUA identifies, assesses, develops and validates innovative governance instruments and approaches to support and accelerate a transition towards sustainable and equitable water use in Europe. Such a transition is urgently required to reconcile water uses and environmental needs and to reach the aims of the EU WFD, the Green Deal and the UN SDGs. By adopting an inter- and transdisciplinary methodology that combines case studies with living labs, the highly skilled GOVAQUA team will systematically analyse and compare existing water governance systems across Europe, focusing on water use and its impacts in agriculture, industries, energy production, water utilities and the role of citizens. GOVAQUA conceptualises for the first time sustainability transition in water governance, and creates associated criteria and indicators for its assessment. In order to respond to systemic development needs for the transition, the project covers niche governance innovations in 1) legislation and regulation, 2) multi-stakeholder participation and collaboration, 3) economics and finance, and 4) digital solutions for information sharing. Good practices related to them are systematically reviewed, analysed and compared, and further co-developed, assessed and validated with key stakeholders in real-world action situations of six living labs in river basins, sub-basins or catchments in France, Finland, Spain, the UK and Romania, and transnationally between Finland and Sweden. GOVAQUA delivers new knowledge, participatory tools and good practice guidelines laying out pathways towards sustainable and equitable water future. The project results will be disseminated in a strategic and targeted manner to EU and Member State policy makers and officials, European river basin management community, water and water using sectors, NGOs and water governance expert organisations, and communicated to empower citizens in the consortium partner countries and beyond.

Keywords: sustainability transition participatory approaches citizen science living labs
Exploring the PFAS alternatives-induced immunotoxicity and impact on intercellular communication. (EPIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: SIGNED

Per- and polyfluoroalkyl substances (PFASs) are emerging environmental contaminants which are highly persistent in the environment with multiple hazardous properties including immunomodulation/immunotoxic potency. Human exposure to PFASs has been associated with various immune-mediated diseases and outcomes. Recently the European Chemicals Agency (ECHA) called for a gradual ban of over 10,000 PFAS compounds in Europe. As concerns grow about the persistence and toxicity of PFAS, the market has shifted towards new PFAS alternatives, however, little is known about the potential risks of these newer chemicals. PFASs have now widely been replaced in many consumer products with PFASs with longer carbon-chains, like perfluoroundecanoic acid (PFUnDA). Rising exposure levels of PFUnDA has been already observed and it was reported previously to have negative effect on the immune system in vitro and in vivo. Blood plasma transports mRNA that modulate immune responses and also extracellular vesicles (EVs) that play key role in intercellular communicationthat and can transport biologically relevant cargo, including microRNAs (miRNAs), and may partly mediate the effects of pollutants on the immune system. This project aims to determine how new PFAS alternatives affect the immune system in long term exposure. To fully understand the mechanisms and to address the multifaceted nature of chemical induced immunotoxicity, the study focuses on changes of key mRNA biomarkers related to the immune system and on the EV-miRNA cargo of extracellular vesicles in long term PFUnDA exposure. Our goal is to develop a multi-biomarker palette identifying key mRNAs and EV-miRNAs in zebrafish to screen novel chemicals for their immunotoxic potency, that is high throughput, quick and easily measured from blood.

Keywords: pfas,pfunda,immunotoxicology,extracellular vesicles,mrna,ev mirna,zebrafish
Designing long-term systemic transformation frameworks for regions – Accelerating the shift towards climate neutrality (TRANSFORMER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Coordination and support actions
Countries involved: Germany,Italy,Poland,Greece,Slovakia,Belgium
Call: Accelerating the climate transition in difficult contexts: transition super-labs (pilot) (HORIZON-CL5-2021-D2-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 2299937.5
EU funding (EUR): 2299937.5
Participants: 13
Project status: CLOSED

The ambition of the TRANSFORMER project is to design long-term systemic transformation frameworks for regions across Europe in order to accelerate the shift towards climate neutrality. At the onset of the project, a conceptual framework will be developed by mapping, defining, and categorising Transition Super-Labs (TSLs). Actual TSLs will be piloted in four regions: the Ruhr area, DE, Emilia Romagna, IT, Lower Silesia, PL and Western Macedonia, GR. The project will develop a roadmap blueprint, a toolkit (incl. matchmaking mechanisms) and a knowledge hub, on the one hand to support the pilot regions but also to be applied by other regions across Europe. Moreover, an evaluation framework will be developed in order to evaluate the impact of TSLs in the TRANSFORMER pilot regions, as well as the respective tools and structures applied by the pilot regions. Project activities will be accompanied by comprehensive communicate and disseminate activities, providing (intermediate) results of the project and the activities in the pilot TSLs, providing a Hub with information, and offering training and capacity building activities for various target groups and stakeholders. Finally, an Exploitation Plan will be prepared for a long-lasting impact of the project.

Keywords: transition super labs,transformation,regions,governance,climate change,climate neutrality