Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ACARE Goals Progress Evaluation (AGAPE)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: HORIZONTAL ACTIVITIES for implementation of the TRANSPORT PROGRAMME
Action type: Coordination and support actions
Countries involved: Belgium
Call:  (FP7-TPT-2007-RTD-1, 2007)
Start date: 2008-07-01
End date: 2010-06-30
Duration (months): 24.0
Total project cost (EUR): 1031474.0
EU funding (EUR): 506674.0
Participants: 1
Project status: CLOSED

ACARE (the Advisory Council for Aeronautics Research in Europe) adopted a list of priority objectives for its future. One of them is to measure progress towards Vision 2020 goals. The AGAPE project will be the logical continuation of a work package of the ASTERA 3 support action, aiming at the definition of the methodology that will enable periodical quantitative evaluation of the progress being achieved by European R&T activity towards the ACARE goals as defined in the Strategic Research Agenda (SRA). AGAPE will perform the actual measurement. Given the plan of ACARE to have a third edition of the SRA ready in 2012, an updated Vision will have to be prepared around 2010, therefore a first round of goal measurements is necessary in the 2008-9 timeframe. In essence the AGAPE project will verify whether the current and planned R&T activities are meeting an ambition which is in line with SRA, possibly even setting targets for new or revised ambitions beyond 2020. Primarily, EU-funded projects in FP5 and FP6 and – where available – national programmes will be used as the baseline for the analysis. The approach will involve teams of experts in different disciplines who will analyse bottom-up the ongoing aeronautical research, checking individual research projects and mapping them against the framework of the SRA-1. This process will enable ACARE to understand whether the research work is aligned to the solutions proposed in SRA-1 and to make a first assessment of the potential contribution to the relevant goal(s). It will be important to check also if work is taking place on solutions which were not listed in the SRA. The task will involve an understanding of the interface situations to highlight synergies across goals. Special attention will be paid to implementation issues which influence the deployment of technology. The output of the AGAPE project will be used for several purposes but the prime ones to consider are: 1) To provide ACARE with information to allow consideration of next steps (including a future edition of the SRA) 2) To provide information to assess / reassess priorities 3) To contribute to the definition of new research policy objectives; and 4) To provide information to demonstrate the benefits of ACARE’s SRA approach

Keywords: aeronautics,acare goals,research agenda,impact assessment,technology readiness level,technology maturity and deployment
Balkan Vegetables Research Centre for transfer of European knowledge, research and practice (EU-BALKANVEGETABLES)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: Unlocking and developing the Research Potential of research entities established in the EU�s Convergence regions and Outermost Regions
Action type: Coordination and support actions
Countries involved: Bulgaria
Call:  (FP7-REGPOT-2007-1, 2007)
Start date: 2008-02-01
End date: 2012-07-31
Duration (months): 54.0
Total project cost (EUR): 1121495.33
EU funding (EUR): 1000000.0
Participants: 1
Project status: CLOSED

The initiatives of the project aim to support the progress of Maritsa Vegetable Crops Research Institute to be reinforced as a modern, competitive one in European horticultural science and to become a leading research center for Balkan region. Coordination and Support Actions proposed here comprise: 1) Recruitment scientists from leading European Institutes to transfer the recent achievements of European knowledge of plant genetics diversity, pest risk analysis, plant nutrition and organic production; 2) Enhancement the professional level of young researchers and exchange of know-how and experience for senior scientists in relevant advanced European Institutes; 3) Improvement and up grading the technical status of Institute with new trends equipment; 4) Establishment of Maritsa VCRI as a dissemination centre and promoter of European knowledge and practice in the field of vegetable science in Bulgaria as well as in Balkan region; 5) Support of Maritsa Technology Transfer Office as an innovative centre and as an interface between the Institute and farmers and processors to transfer the advanced European technologies. The potential impacts will be: 1) acquaintance of Bulgarian researchers with the latest achievements in management of vegetable resources, pest risk analysis and soil fertility management, 2) creation of new generation of young researchers, experienced in high level management of vegetable resources, 3) achievement of comparable and competitive level to the ERA’s due to the improvement of technical status of Institute, 4) elaboration of strategy for Bulgarian vegetable science and development of the Institute as an advisory and dissemination Centre, 5) reinforcing the Balkan collaboration to bring together expertise of different disciplines for preservation and proper management of vegetable diversity in Balkan region. All support and coordination actions will be performed in collaboration with the prestige European research institutes.

Keywords: vegetables,balkan region,european lecturers,young researchers training,equipment up-grading,balkan vegetables linkage,biodiversity,pest analysis and soil fertility management
Jules Horowitz Reactor – Collaborative Project : contribution to the design and construction of new research infrastructure of pan-European interest, the JHR Material Testing Reactor (JHR-CP)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Research infrastructure
Destination: Infrastructures
Action type: Collaborative project
Countries involved: France,Spain,Finland,Czechia,Belgium
Call:  (FP7-Fission-2007, 2007)
Start date: 2009-01-01
End date: 2010-03-31
Duration (months): 15.0
Total project cost (EUR): 3421446.0
EU funding (EUR): 1750000.0
Participants: 7
Project status: CLOSED

The present proposal addresses the support to the Jules Horowitz Material testing reactor, a new research infrastructure of pan-European interest (Topic Fission-2007-4.1.2). In the EURATOM field of fission, the Jules Horowitz Reactor (JHR) appears to be an innovative project (FEUNMARR &amp; ESFRI), firstly from the technical point of view as an up-to-date high performance material testing reactor (MTR), secondly through a funding and steering structure gathering several European research institutes and industrial companies. The overall JHR project that encompasses the JHR design and construction is generally designates as the “JHR project”. In the following “JHR-CP” designates the 7th FP Collaborative Project proposed as a contribution to the overall JHR project. The JHR-CP project will include several networking activities related to : - the management of the project, - the organizational aspects of the experimental processes attached to this experimental reactor, - the training, with the definition of academic and professional training related to the specific JHR experimentation and operation needs based on the best European practices. In the same way the JHR-CP project will include several Technical activities related to the JHR design and construction. Those activities are concerning more specifically : - the qualification programme of the critical components of the reactor, - the qualification tests of specific components, - the man machine interface principle’s definition, - the safety analysis and actions, the definition of some supports to JHR experimentation.

Keywords: material testing reactor,new infrastructure,construction,design,jules horowitz reactor,qualification programme,qualification tests,critical components,man machine interface,safety analysis
Development of Space Astrophysics in Crete (ASTROSPACE)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: Unlocking and developing the Research Potential of research entities established in the EU�s Convergence regions and Outermost Regions
Action type: Coordination and support actions
Countries involved: Greece
Call:  (FP7-REGPOT-2007-1, 2007)
Start date: 2008-03-01
End date: 2011-02-28
Duration (months): 36.0
Total project cost (EUR): 1609499.0
EU funding (EUR): 1120000.0
Participants: 1
Project status: CLOSED

Space Astrophysics is a research domain which has benefited greatly from the recent advances in technology and has contributed to the most fundamental discoveries in various areas of Astrophysics over the past 20 years. The nature of operation of space observatories (all experiments are designed remotely and data is archived in servers accessed via the web) make it possible for researchers in regions in the outskirts of Europe with no access to other major research facilities to perform high quality science. Over the past three years the Astrophysics Group in the island of Crete (Greece) has invested a considerable fraction of its human resources in Space Astrophysics by hiring three new tenure track faculty with expertize in X-ray and Infrared Space Astrophysics. We propose to use the opportunities provided by the Capacities Program to further develop the research potential of our group. Our project will be based on twinnings with top Space Research Institutes in Europe (CEA/Saclay, France and MPE/Garching, Germany), on hires of experienced researchers, on upgrading our telescope equipment, and on workshop/conference organization. Our goal is to train our local personnel and improve the visibility of the group so that at the end of the proposed program the group will be at a level which will enable it to collaborate with major european research centers on forefront research projects.

Keywords: x-ray infrared space astrophysics
Integration of CryptoD to ERA (ICE)

Framework: FP7 — Capacities
Programme: Research Potential
Destination: Unlocking and developing the Research Potential of research entities established in the EU�s Convergence regions and Outermost Regions
Action type: Coordination and support actions
Countries involved: Türkiye
Call:  (FP7-REGPOT-2007-1, 2007)
Start date: 2008-05-01
End date: 2011-04-30
Duration (months): 36.0
Total project cost (EUR): 1329480.0
EU funding (EUR): 1149978.0
Participants: 1
Project status: CLOSED

As we move into an information society, the need for the security and privacy of communications and information exchange has been raised. In this environment, Information Security and Cryptography has become one of the main tools for maintaining privacy and confidentiality. Being a centre of excellence, Cryptology Department (CryptoD) plans to utilize its research and development resources towards activities for better integration to ERA. The main objective of this proposal is to improve the research capacity of TUBITAK UEKAE CryptoD in the area of cryptographic algorithms/protocols and their applications to wireless security and formal verification methods/tools. Such improvement in the CryptoD’s research capacity, will promote enhanced participation in the projects of Framework Programmes in the domain of ICT and Security. We aim to achieve this objective by improving our S&T capacity through the following:  reinforcing human potential by enlarging our group,  organising and/or participating in training activities such as short term courses, summer schools, series of seminars, workshops and conferences,  organising and/or participating in meetings or brokerage events with European research centres having similar scientific interests to prepare joint RTD proposals,  dissemination of scientific knowledge and information from CryptoD, and  improve networking with researchers in EU by the above means The objective and the above approaches basically serve the promotion of our cooperation with RTD communities in Europe and with this point of view; they correspond to the aims of Call FP7-REGPOT-2007-1.

Keywords: information security,cryptography,wireless security,rfid security-privacy
Simulations of Turbulent, Active and Rotating Suns and Stars (STARS2)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Systems and communication engineering
Countries involved: France
Call:  (ERC-2007-StG, 2007)
Start date: 2008-09-01
End date: 2013-08-31
Duration (months): 60.0
Total project cost (EUR): 880000.0
EU funding (EUR): 880000.0
Participants: 1
Project status: CLOSED

The STARS2 project aims at modelling on massively parallel supercomputers in a self-consistent and three-dimensional way, the complex, time dependent and nonlinear dynamics operating in the Sun and stars. In particular we wish to understand how stars generate the wide variety of magnetic activity that is observed, with the Sun - given its proximity and its influence on our technical society - playing a central role in characterizing, studying, and constraining the dynamical processes acting in stellar convection and radiation zones. Studying the solar-stellar connection is crucial because it will allow us to understand why depending on the spectral type of the star considered, this activity can be cyclic, irregular, or simply modulated. The mechanism thought to be at the origin of the magnetism seen in late type stars is likely to be linked to dynamo action in the upper convective layers of such stars. The simultaneous existence in stars of convective turbulent motions, of rotation and its associated shear layers, favour the emergence of a small and/or large scale magnetic field through induction. For more massive stars, possessing a convective core, understanding the interaction between the dynamo generated magnetic field in the core and the magnetic field of their radiative envelope constitute major challenges in stellar fluid dynamics. To achieve these challenging scientific goals, the STARS2 project propose to federate a team of young bright scientists around the PI and to perform and to analyse sophisticated and more realistic high performance global MHD numerical simulations of the Sun and other stellar spectral types. These simulations are at the front-edge of current research in astrophysics, they require the use of the latest class of supercomputers available in Europe and will lead to real scientific breakthroughs. Understanding the interactions between convection, turbulence, shear, rotation and magnetic fields in stars IS the main goal of this project.

Keywords: solar and stellar magnetism and fluid dynamics,convection,mhd,dynamo,turbulence,instabilities
Time-resolved Ring-Cavity-Enhanced Polarization Spectroscopy: Breakthroughs in measurements of a) Atomic Parity Violation, b) Protein conformation and biosensing and c) surface and thin film dynamics (TRICEPS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Fundamental constituents of matter
Countries involved: Greece
Call:  (ERC-2007-StG, 2007)
Start date: 2009-01-01
End date: 2014-12-31
Duration (months): 72.0
Total project cost (EUR): 909999.0
EU funding (EUR): 909999.0
Participants: 1
Project status: CLOSED

Polarimetry is a crucial tool in both fundamental and applied physics, ranging from the measurement of parity nonconservation (PNC) in atoms, to the determination of biomolecule structure, and the probing of interfaces. These measurements tend to be extremely challenging as the change of the polarization of light is usually extremely small; typical differences in polarization states are of the order of 10^-5 to 10^-8. Current experimental techniques often require acquisition times of the order of seconds or, in the case of PNC, even many days, limiting the possibilities of time-resolved measurements. Here, I propose to develop optical-cavity-based techniques which will enhance measurements of the polarization sensitivity and/or the time-resolution by 3-6 orders of magnitude. Preliminary data from prototypes and feasibility studies are presented. I propose to demonstrate how these breakthroughs will revolutionize polarimetry, by addressing some of the most important multidisciplinary problems in fundamental physics, biophysics, and material science: a) Testing the limits of the Standard Model with atomic PNC measurements. Current PNC experiments, and more importantly theory, for cesium atoms are limited to precision of about 0.5%. The novel and robust experimental technique I am proposing here affords 4 orders-of-magnitude higher sensitivity, thus giving access to lighter atoms, where the theory can be better than 0.1%, for the most stringent test of the Standard Model, while seeking new physics. b) The measurement of protein folding dynamics. Highly sensitive time-resolved spectroscopic ellipsometry, providing novel dynamical information on protein folding: nanosecond resolved, position measurements of functional groups of surface proteins, which map out the time-dependent protein structure. c) Determination of thin film thickness and surface density with nanosecond resolution, for the study of processes such as laser ablation and polymer growth.

Keywords: polarimetry,ellipsometry,atomic parity violation,biosensors,protein folding,polymer thin film glass transition,laser ablation
Role of ColQ, a specific collagen in the functionnal organisation of the neuromuscular junction (COLQ AND THE NMJ)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2008-01-01
End date: 2009-12-31
Duration (months): 24.0
Total project cost (EUR): 30000.0
EU funding (EUR): 30000.0
Participants: 1
Project status: CLOSED

My research project is based on one principal axis: how extracellular matrix proteins participate to the functional organisation of the synapse. The goal of my research project is to study ColQ induced regulation of acetylcholine receptor (AChR) expression process. Recently, during a collaborative project between Jean Cartaud and Claire Legay groups, we have shown that the C-terminal part of ColQ interacts with MuSK (muscle-specific tyrosine kinase receptor) ectodomain. This association is not only responsible for anchoring AChE in the synaptic basal lamina but could also play an important role in regulating AChR expression. Other works have shown that ColQ interacts with another partner, the perlecan, an extracellular matrix heparan sulfate proteoglycan (HSPG) interacting with the Dystroglycan (DG). Based on these evidence, we hypothesized that ColQ could regulate the number of AChR via MuSK and/or perlecan/dystroglycan pathways. These signalling pathways would then be used as pivot adapting the number of AChE molecules to the number of AChR. Preliminary results from the laboratory confirm this hypothesis and suggest that ColQ regulates AChR and synaptic proteins expression and also suggest that ColQ may act via the two signalling pathways MuSK and perlecan/dystroglycan. Using various complementary approaches of biochemistry, cellular and molecular biology both in vitro and in vivo in mice, I will identify the signalling pathways induced by ColQ, in particular those involving ColQ/perlecan/dystroglycan and ColQ/MuSK. This study will allow me to better understand the mechanisms by which ColQ controls the postsynaptic domain differentiation at the NMJ.

Keywords: neurobiology,neuromuscular junction,colq,signalling pathways,motoneuron axon guidance
Role of the Gadd45 family and p38 MAPK in tumor suppression and autoimmunity (GADD45&P38SIGNALING)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Cellular and Developmental Biology
Countries involved: Spain
Call:  (ERC-2007-StG, 2007)
Start date: 2008-09-01
End date: 2014-08-31
Duration (months): 72.0
Total project cost (EUR): 1755805.0
EU funding (EUR): 1755805.0
Participants: 1
Project status: CLOSED

Gadd45 family proteins play a critical role in genomic stability, cell cycle regulation proliferation and apoptosis. Gadd45a is activated by the tumor suppressor gene p53, which is mutated in &gt;50% of human tumors. The lack of GADD45a in mice leads to spontaneous development of an autoimmune disease similar to systemic lupus erythematosus. The molecular mechanisms that cause autoimmunity are poorly understood. Recent evidence suggests that p38 activation is involved in autoimmune development and tumor suppression. We found that Gadd45a negatively regulates p38 activity in T cells by preventing phosphorylation on Tyr323. Inhibition of Tyr323p38 phosphorylation is a potential therapeutic target in several types of leukemia and autoimmune diseases, including lupus and rheumatoid arthritis. The main goals of this project are a) to study the in vivo function of the Gadd45 family and p38 in tumor suppression and autoimmunity, and b) to analyze their molecular mechanisms to identify targets for disease treatment. We will dissect the signaling pathways involved in development of autoimmunity and cancer using a multidisciplinary approach that combines mouse genetic, human epigenetic, biochemical, molecular biological and immunological techniques. Our project involves the characterization of murine models deficient in each member of the Gadd45 family (Gadd45a, Gadd45b, Gadd45g), as well as double- and triple-knockout mice, development of a knock-in model for p38a, in vivo and in vitro analysis of T cell activation, proliferation, apoptosis and differentiation, epigenetic studies of potential targets, and finally, validation of these results in autoimmune disease and cancer patients. The results of this project will help identify new therapeutic targets for autoimmune diseases and/or cancer.

Keywords: gadd45a,gadd45b,gadd45g,p38 mapk,autoimmune disease,cancer,tumor suppressor,t cell activation,proliferation,apoptosis,sle