Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Nanotechnology Based Blood Culture Medium to Detect Invasive Candida in Bloodstream (CandidaHunter)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Türkiye
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

CandidaHunter is the latest diagnostic innovation of Matriks Biotek®, owing to its years of expertise on medical biotechnology. The company has already developed and commercialized many diagnostic kits distributed over 37 countries around the world. This time Matriks Biotek targets Candidiasis, a fungal infection affecting roughly a million of people each year, making it the 4th leading cause of hospital infections. The mortality rate of 40% associated with the disease shows there is still much to improve in antifungal therapy. The Challenge The most crucial need in Candidiasis treatment is fast diagnosis. Blood culture is the gold standard assay for Candidiasis diagnosis but can only detect 50% of the cases within 3 to 5 days. Delayed treatment and undiagnosed cases lead to dissemination of the disease and cause severe infections in internal organs. Our Solution Matriks Biotek introduces CandidaHunter as a fast blood culture medium to detect Candidiasis in bloodstream. Enhancing the golden standard with nanotechnology, CandidaHunter offers an increased detection sensitivity of 80% and a much shorter diagnosis period of 24 hours. The Opportunity Factors like high incidence of infections, rising demand for fast diagnostic tests, aging population as well as advancements in medical technology always make newer and better solutions highly sought after. Considering its unique features, Matriks Biotek believes CandidaHunter will easily make a name for itself all around the world. Culture based technologies have the largest share in the diagnostic market due to the extensive usage of conventional blood culture media. By commercializing it on global scale, Matriks Biotek aims to benefit from CandidaHunter with its potential leverage effects and apply its capabilities to a new market. Matriks Biotek is an R&D intensive SME established in 2002 with a main focus on therapeutic drug monitoring and immunogenicity detection.

Keywords: candida,yeast,blood culture
Individual Behaviour and Economic Performance: Methodological Challenges and Institutional Context (IBEP)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Israel,Estonia,Finland
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 900000.0
EU funding (EUR): 900000.0
Participants: 4
Project status: SIGNED

Individual Behaviour and Economic Performance: Methodological Challenges and Institutional Context is a project led by Tallinn University of Technology (TalTech, Estonia) in collaboration with internationally leading counterparts Aalto University (Finland), University of Helsinki (Finland) and Tel Aviv University (Israel). The project aims at networking between the partners for research capacity building at TalTech and achievement of lasting synergies in the consortium in the academically and societally promising area of generating a better understanding of linkages between individual behaviour and economic performance. Behavioural economics has deepened our understanding of various deviations from rationality in economic performance. Economic outcomes of prevalent individual differences in cognitive capacity and neurophysiology as well as in beliefs and preferences warrant further investigation. Moreover, better designed economic policy and institutions, which take into account that people are different and their wellbeing responds differently to any given policy measures, leads to better utilisation of human capital endowment and enhanced economic performance. The project is a joint effort of economics, finance, practical philosophy and neuroscience scholars, where several internationally highly renowned professors work under a comprehensive set of networking and capacity building activities together with established and early stage researchers in a stimulating multidisciplinary setting. The cohesive consortium provides a unique platform for achieving novelty and excellence in research and developing the research profile of TalTech and its team by integrating TalTech and the partners into a highly functional and unique interdisciplinary partnership. The value of the project builds on a societally challenging research field, advanced contemporary research methodology and cost-efficient knowledge transfer activities for long-lasting effects in research excellence.

Keywords: behavioural economics,behavioural finance,methodology of economics,institutions,neurosciences,interdisciplinary,individual differences
Surveillance and Moral Community: Anthropologies of Monitoring in Germany and Britain (SAMCOM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1476127.5
EU funding (EUR): 1476127.5
Participants: 1
Project status: SIGNED

Surveillance—the mediated monitoring of human behaviour for some intended purpose—has become part of the structure of European life. As ubiquitous monitoring technologies transform every new relationship that they mediate, there is grave concern that the social gains of past centuries will be lost, as states and large corporations use these technologies to expand and entrench their own power. Scholars of surveillance have been following these developments since the 1970s, but recently have faced the paradox that most surveillance now takes place with the active collaboration of the surveilled. Moreover, the enthusiasm for self-monitoring popularized through smart technologies has been met by many surveillance scholars with bewilderment. Why would people choose to enter relationships objectively deemed to be coercive? This project takes a new approach to how we understand surveillance. I embark on the first sustained inquiry into the association between surveillance and moral community, between practices of ‘watching over’ and the presence of a group of people who share a commitment to certain goods. By ethnographically investigating the role that surveillance technologies play in realizing four different types of good—care, health, safety and citizenship—within four different communities—the family, the interest group, the circle of intimates, and the nation—this research explores how surveillance proliferates not as a lever in power relations, but by being harnessed to forms of human welfare. The gains of this project are substantial. To surveillance studies I import insights from anthropology, offering a comparative and embedded approach that situates surveillance as a social relationship. I also initiate a major conversation about surveillance in anthropology. Finally I develop the concepts of ‘moral’ and ‘immoral’ monitoring, achieving greater public clarity on those forms of surveillance that support collective welfare, and those that threaten to harm it.

Keywords: anthropology,ethnography,surveillance,dataveillance,datafication,monitoring,performance,morality
OPTICAL PROGRAMABLE ASSEMBLY OF NANOMATERIALS (OPAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-02
End date: 2024-07-03
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Recently, I have pioneered the development of a technique of light-induced reconfigurable nanostructured materials. This process consists of the displacement of the nanostructures inside a solid host medium with the action of light. When an incident light beam interacts with the nanostructures, a photon momentum transfer takes place. This momentum serves to displace/rotate the nanostructures inside the medium. During the writing process, the standing waves can assemble complex patterns in a reversible fashion. My research plan includes both the theoretical and experimental aspects of this light-induced self-assembly phenomenon. Theoretical developments will provide an insight into the effect that standing light waves have on embedded nanoscale objects. It is necessary to model the optical, mechanical and thermal characteristics of materials to identify the optimal conditions for low energy assembly of complex nanostructured architectures. Experimentally, I aim to demonstrate the assembly of a metamaterial consisting of crystal nanostructures through standing waves of both, linearly and circularly polarized light. This device will function as an active wave plate that can rotate the polarization of incident light. Subsequently, I will fabricate and demonstrate a tunable laser device by arranging nanoparticles into photonic crystal-like structures. Standing waves will be employed to record multilayer assemblies that will act as resonant cavities. The addition of a fluorescent organic dye, quantum dot or perovskite nanocrystal dispersed into the multilayer structure will provide the necessary conditions to induce stimulated emission to produce laser light. This project will set the ground for the fabrication of low-cost composites for photonic crystals for programable lasers and metamaterials for active wave plates. It is envisioned that this assembly mechanism will also permit the development of a new class of ‘robotic material’ with unprecedented functionalities.

Keywords: photonics,optics,lasers,holograms,materials,nanotechnology
Anisotropic High-Density Carbon Nanotube Coatings for Thin-Film Electronics (CNT-Nanostickers)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This project proposal aims at developing a new manufacturing technology for processing nano-materials by combining emerging scientific insights in nanoparticle assembly with scalable production processes. Our goal is to establish the first scalable technology to make thin-films comprising densely packed aligned Carbon Nanotubes (CNT) of highest quality. These films will be fabricated by controlled wet deposition and transfer techniques, and used as a high-performance material for device fabrication. On the longer term, the same principles could be extended to the production of transparent conductors, sensors, and to variety of other applications. As a demonstrator, horizontal CNT-interconnects targeting a resistivity below 100μΩ•cm will be fabricated. At this value CNT become a viable alternative to Copper in Microelectronics. This disruptive push of CNT-interconnects into commercially competitive specifications will be enabled by: the superior quality of the CNTs used in the CNT-films, advances in their transferring, the skillset of the host-group in nanoparticle’s assembly and manufacturing processes and the 7-years expertise of the applicant in CNT-interconnects. The network of both participants in various European countries and the assistance of IMEC (Belgium), partner organization to this project, will facilitate the implementation of this research for enabling a true industrial impact on EU economy.

Keywords: carbon nanotubes,interconnects
USLAMISM: The United States and Political Islam: A Historical and Contemporary Perspective. (USLAMISM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2020-08-31
Duration (months): 36.0
Total project cost (EUR): 251857.8
EU funding (EUR): 251857.8
Participants: 2
Project status: CLOSED

At a time when various Islamist groups are in close proximity to power, this project aims to examine the relations between the US and forces aligning themselves with Islamism . It is meant to understand the mechanisms of US policy towards this ideology. What are the issues arising from the diplomatic relations linking the US power and the representatives of an ideology traditionally opposed to them? What conceptions of Islamism –both historical and contemporary– has been guiding US foreign policy? The research process will be structured along two dimensions. The first is a historical investigation based on State Department and Presidential archives and sources handed down by US foreign policy practitioners dealing with Islamism over several decades. The second dimension consists of an examination of the contemporary state of play using interviews, discourse analysis and a study of US foreign policy actions towards Islamist forces. USLAMISM is original in three ways. First, the study proposed here deals with the external policy of states towards a transnational panislamic group which does not recognize the nation state as a working constituent of the political system. Second, regarding worldviews, Islamist movements may continue to rely upon an anti-Western ethic in shaping their political agendas; this despite various reorientations within these groups in recent years. Finally, with various Islamist forces currently exercising power or close to it, how can we come to terms with the significant differences in worldview held by these interlocutors? What is the best way to deal with groups which constitute ideological opponents but become sometimes partners –even allies– in the geopolitical sphere?

Keywords: us foreign policy,political islam,muslim brotherhood,islamic world,arab world,middle east,history of international relations,neo realism and constructivism,cold war,arab uprisings
Precision Multi-Spectral Optoacoustic Tomography for Discovery Diagnosis and Intervention (PREMSOT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 2497268.0
EU funding (EUR): 2497268.0
Participants: 1
Project status: CLOSED

The 2008 ERC Advanced Grant multispectral optoacoustic tomography (MSOT) yielded a novel modality for post-genomic small animal optical imaging, >110 peer-reviewed publications and several major awards including the 2014 Germany’s Innovation award. Since 2011 spin-off iThera Medical GmbH commercialized and placed MSOT systems in European, Asian and North American laboratories, making MSOT an international term. MSOT brought unprecedented optical imaging performance now enabling independent discovery and publications from researchers throughout the world. Compared to other imaging modalities, MSOT uniquely images tissue oxygenation and other vascular and pathophysiology parameters in label-free and portable mode, using safe non-ionizing energy. Therefore, MSOT can impact real-time interventional guidance and longitudinal vascular diagnostics and enable a next level of discovery based on quantitative observations in humans, within the novel requirements of precision and personalized medicine. PREMSOT considers the next steps in the MSOT development and will ❶ design and develop label-free portable hybrid MSOT and ultrasound imaging (US) for human use, ❷ research novel theory and hardware to address remaining MSOT limitations and improve the sensitivity and quantification accuracy, a necessary step for improving MSOT precision, ❸ i) validate quantitative MSOT imaging of tissue oxygenation and hypoxia, (micro)-vascular morphology and function, ii) research label-free imaging of inflammation and metabolism and iii) relate MSOT contrast to tissue and disease pathophysiology metrics and ❹ introduce label-free MSOT/US to discovery and clinical care. MSOT contrast features will be investigated as biomarkers in vascular medicine and surgery and in exploratory measurements within neurology, ambulatory/bedside care or sepsis, addressing unmet discovery and clinical needs.

Keywords: imaging,tissue oxygenation,hemoglobin,sepsis,intervention
Iridium Catalyzed Reductive Cyclization Cascades (ICRED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-11
End date: 2018-07-10
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The aim of this fellowship is to develop new reductive cyclization cascades of lactams and amides that establish these feedstock chemicals as important chemical precursors to reactive iminium ions which can be intercepted by pendant nucleophiles and exploited in carbon-carbon bond formation. A range of indole nucleophiles linked to amide and lactam functionality will be investigated for performance in the iridium catalyzed reductive cyclization cascades, and, based on successful proof of concept studies already performed in the Dixon group, a range of semi-saturated nitrogen-containing polycyclic structures possessing one or more stereocentres distributed over an architecturally complex framework should result. As well as studying diastereocontrol in the cascades, catalytic enantioselective variants will also be investigated. Finally, the application of the indole (spiro)cyclization reaction to the total synthesis of aspidospermidine will showcase the utility of the developed chemistry. This multidisciplinary Fellowship, based on high-quality and novel research at the University of Oxford, one of the top-research centres worldwide, will complement Dr Xie’s skills and knowledge to improve his career possibilities and at the same time, Dr Xie’s experience in creating catalytically active transition metal complexes will be critical for developing chiral versions of the iridium catalyst during the development of a catalytic asymmetric version of the reductive cyclization cascade.

Keywords: organic synthesis,catalysis,iminium ion intermediates,total synthesis,alkaloids,enantioselective
Chromatin targeting and remodelling by bacterial effectors in plant immunity (CHERI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

In nature, plants are challenged by disease-causing pathogens such as viruses, bacteria and fungi. Understanding mechanisms of plant disease and disease resistance is of fundamental importance to sustainable agriculture and human health. Unlike mammals, plants lack a circulating immune system. Plants instead rely on the innate immune capacity of each cell and systemic signals that disseminate from infection sites. Successful pathogens use effectors to suppress plant immunity and cause disease. Plants have evolved disease resistance genes encoding immune receptors that perceive specific pathogen effectors to mount effector-triggered immunity. In Arabidopsis, a heteromeric pair of intracellular immune receptors forms a functional recognition complex which senses virulence activities of two structurally unrelated bacterial effectors at the nuclear chromatin. Results suggest that effector targeting of histone modifications and chromatin remodelling interferes with host basal immunity and that this is transduced by the receptor pair to activation of defence pathways. The underlying molecular mechanisms remain unclear. We have found that the two bacterial effectors interact with an overlapping set of chromatin-associated proteins and with certain immune receptor domains. We hypothesize that the effectors converge on the same chromatin machinery for promoting disease and that their actions are intercepted by the immune receptor system which is physically connected to basal immunity signalling components. By using the effectors as molecular probes, this proposal aims to elucidate how the chromatin environment is modulated during infection and how effector perturbations are converted to effective immunity.

Keywords: innate immunity,pathogen effectors,nlr receptors,chromatin dynamics,transcriptional,regulation