Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Harnessing the electric potential of cable bacteria to generate electricity sustainably (Cable electricity O2)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-08-01
End date: 2025-07-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: SIGNED

Cable bacteria are centimetre-long, filamentous, multicellular bacteria present ubiquitously in freshwater and marine sediments, and participate in long-distance electron transfer by coupling the oxidation of sulphide in anoxic sediment to the reduction of oxygen. Cable bacteria possess an internal electric grid, enabling them to transport electrons over centimeter-scale distances. This project proposes the cultivation of cable bacteria on electrodes to harness their potential to generate electricity. Further, the development of a switchable bioelectrochemical system altering between electrogenesis and electrotrophy is proposed. Such a device would enable biological power generation and energy storage in a single device, and will be tested to power a microprocessor biologically, enabling development of biodegradable electronics. These experiments would be performed in specialized bioelectrochemical systems by varying the applied potential from positive to negative to induce the switch. Electrochemical interactions of cable bacteria with electrodes will be monitored by amperometry, voltammetry, and impedance spectroscopy. The cables will be integrated into a power management system consisting of a microprocessor chip, a current and voltage-measuring circuitry and a microcontroller to power the microprocessor with electrons obtained from the sediment. Finally, the physiological possibility of dark oxygen generation by cable bacteria in anaerobic sediments will also be explored, that would enable the use of cables as intermediates to convert any aerobic microbe into an electrogen. This mechanism will potentially uncover an unknown mode of oxygen production and usher in a completely new understanding of oxygen transport through the oxic-anoxic interface. The project bridges the applied and fundamental by probing cable bacteria electrophysiology to develop robust applications that will enable sustainable power generation.

Keywords: electromicrobiology
Microbiota-T cell interactions - antigen-specificity and regulation in health and disease (MicroT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: SIGNED

The microbiota has an enormous influence on human health. CD4+ T cells play a central role in controlling the interaction with the microbiota. By specifically reacting against individual microbial species, T cells enable a mutualistic co-existence with microbes. Inappropriate T cell responses against microbes are in turn associated with inflammatory diseases. Thus, the combination of T cell specificity and functionality form the key determinant for physiological versus pathological host-microbiota interactions. So far, research on T cell-microbiota interaction is almost exclusively focussed on functional T cell subsets, whereas antigen-specificity is rarely addressed. This is a significant roadblock for developing targeted therapeutic interventions for microbiota-associated diseases. The interaction with the microbiota poses two particular challenges for adaptive immunity: first, the extremely high diversity of microbial species, and thus potential T cell targets; second, microbes are persistent and thus probably encountered chronically. Currently, we do not know (1) which microbes are targets of specific T cell reactivity in humans, (2) how the (chronic) interaction with the huge number of different microbial species is regulated by T cell specificity and function, and (3) how alterations of these parameters contribute to microbiota-associated diseases. I developed a highly sensitive technology to detect and deeply characterize microbe-specific T cells directly from human samples. MicroT will identify microbial target species of human T cells and unravel the molecular mechanisms regulating chronic interaction of T cells with the highly diverse microbiota. I will define the impact of specific T cell-microbiota interactions on chronic inflammatory diseases and upon ageing. Answering these fundamental questions of microbiota-T cell interaction will identify specific immune or microbial targets as an essential basis for rational development of novel targeted therapies.

Keywords: antigen specific cd4 t cells t cell microbiome interaction t cell cross reactivity regulation of microbe reactive t cells
A Novel Approach to New Family-Forms, Assisted Reproductive Technologies and Transnationalism. A multi-sited ethnography: Spain, Denmark, Canada and Israel (REPRO-SCAPES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Spain,Israel,Canada
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-02-01
End date: 2029-01-31
Duration (months): 60.0
Total project cost (EUR): 2039969.0
EU funding (EUR): 2039969.0
Participants: 4
Project status: SIGNED

The global assisted reproductive technologies (ARTs) market is expected to reach USD 45 billion by 2025 with more than 8 million babies born. Europe dominates the market followed by North-America and Asia. However more than half of European states and most countries in the Americas and Asia prohibit access to ARTs to solo individuals, same-sex couples and heterosexual couples who need donated eggs, embryos or surrogacy. It is a prime example of contemporary technological transnationalism with potential parents pursuing treatment abroad in the hopes of conception. As ARTs spread to populations that have not had access to them before, how is reproduction being transformed by technologies and individuals whose sexual and reproductive lives may defy social norms and national laws? Due to biotechnologies and the populations who seek ARTs a new theoretical framework for cross-border reproductive care is necessary. The overarching aim is to study the question of ARTs, new family-forms and transnationalism in three ways: Firstly by exploring how the transnational circulations of ARTs, bodily material and ideas take form in three continents: Europe, North-America and the Middle-East (multi-sited ethnography). The second is through the ethnographic approach of analysis of specific locations, examining how technologies, genetic flow and ideas come to settle in four countries, leaders in ARTs and sexual and reproductive health rights (single-site ethnographies): Spain, Denmark, Canada and Israel. Thirdly, by studying the complexity and intersection of the biological, social, politico-legal and ideological between new family-forms and ARTs, and how these intersections shape their experiences. I am uniquely positioned to implement this study due to my pioneering scholarship on ARTs and new family-forms from a strong interdisciplinary stance and solid experience of managing international teams, bringing together divergent empirical contexts for ground-breaking research.

Keywords: assisted reproductive technologies,new family forms,transnationalism,spain,denmark,canada,israel
Reprogramming immunity for a brighter future for autoimmune patients (ADCure)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Autoimmune diseases (ADs) affect 1 in 10 individuals worldwide, with women being disproportionately affected (accounting for ~80% of diagnoses). In ADs, the immune system mistakenly targets healthy tissue instead of pathogens, leading to chronic and debilitating conditions. Existing immunosuppressive treatments lack any specificity to the autoreactive components, hence, have significant limitations including inducing susceptibility to severe infections and increased cancer risk. Balancing symptom control and side effects remains a clinical challenge. None of the current therapies addresses the AD root causes or offer a cure. At Canopy, we developed a novel class of biologics to overcome these limitations. Our proprietary Reverse Immunization® technology pioneered a new class of biologics, Antigen Drug Conjugates, that act via two mechanisms of action: (1) Eliminates pathogenic autoantibodies through antibody sequestration and facilitated immune complex clearance; and (2) Specifically targets autoreactive pathogenic B-cells via their membrane-bound clonal antibody, the B-Cell Receptor (BCR), and delivering a cytotoxic payload that eliminate them. This unprecedented specificity allows precise targeting of small autoreactive populations while preserving an immunocompetent immune system. Canopy’s approach not only eliminates the risks associated with immunosuppression, but also offers a potential symptom-free, drug-free, years-long remission or even cure. Our rapid development cycle and deep product pipeline mark a historic milestone, with the promise to revolutionise AD therapeutics. With EIC support, Canopy aims to complete Phase I and IIa clinical trials for our 1st product in myasthenia gravis. Simultaneously, we will advance our 2nd product for 3 separate TSHR+ indications, to IND and CTA approvals. Canopy’s vision isn’t just an advancement; it’s a potential revolution in patient care, addressing the €57.2B annual economic burden of ADs in Europe.

Keywords: autoimmune disease,reverse immunisation,antigen drug conjugate,platform technology,potentially curative,biotechnology,myasthenia gravis
Final clinical development of a revolutionary recombinant human protein to stop and prevent life-threatening bleeding (FOLLOWON)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 54.0
Total project cost (EUR): 1.0
EU funding (EUR): 1.0
Participants: 1
Project status: SIGNED

Over 50 million patients globally use oral anticoagulants for thrombosis and stroke prevention. Since the last decade, unpredictable and risky indirect anticoagulant treatments are being replaced by the latest generation of blood-thinning medication: Factor Xa Direct Oral Anticoagulants (FXa-DOACs, used by >10 million patients in EU+US). With superior predictability, efficacy and safety profiles, these life-saving medications remain associated with a risk of uncontrolled and severe bleeding, e.g. during urgent surgeries. Alarmingly, there is no safe reversal agent that restores blood clotting in patients who take FXa-DOACs, leading to life-threatening bleeding episodes and over 250,000 hospital admissions annually. To address the urgent unmet need, VarmX has developed VMX-C001, a revolutionary recombinant therapeutic protein, as the first effective and safe reversal agent for FXa-DOACs. After achieving successful clinical proof of concept Phase 1 study with EIC backing, VarmX now requests an equity support to complete the last major step before market entry, the pivotal Phase 3 trial. This would bring the company in a position to grow towards a European pharma unicorn, disrupting global cardiovascular drug markets.

Keywords: cardiovascular therapies,bleeding,anticoagulants,thrombosis,biologicals,drug development
Spectres & Camouflage: The Sound of Silence (1938-1970) (Spectres-Camouflage)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Ireland
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1499586.0
EU funding (EUR): 1499586.0
Participants: 1
Project status: SUSPENDED

Silence is a rare - often beautiful, sometimes discomfiting - phenomenon. Harnessed in different manners, silence has multiple cultural, societal, scientific, psychological, artistic and military implications. In the 20th C., the impact and exploitation of silence manifested in the technological search for the soundless environment: a search which centred upon environmental control and design. It was shaped by disciplinary and international transfers of knowledge. Ultimately, the technology became known as anechoic (free from echo). However, despite touching on numerous disciplines, and its relevance to a complex interplay of global knowledge-transfer, conflict and culture, very little is known of the architectural, military, and cultural history underpinning the development of this technology. SPECTRES-CAMOUFLAGE examines the catalysts and implications inherent in that technological search, exploring its impact on design and experimentation, military strategy and cultural production. It will explore how the developmental interplay that supported a culturally iconic medium also positioned it at the vanguard of technology and inserted it into global politics and conflict in the 20th C. The timeframe of the project extends from the eve of WWII to 1970. This project will draw together this intricate history, take account of transfers of knowledge and establish the resultant transformations of knowledge. It will integrate the histories of architecture, music, technology and war studies examining how developments in each propelled one another forward. The project?s multidisciplinary strands drawn together will constitute a new prism for learning more about technology transfer across the globe and across disciplines. At its core, this research could reposition the role of technology and environmental design in 20th C. global conflict, culture, and knowledge transfer, offering a new concept of environmental silence as a catalyst, mapped across disciplines.

Keywords: construction history,environmental design in architecture,architectural acoustics
MULTIANALYTE DIGITAL SENSING WITH QR-CODE MICRONEEDLES FOR MINIMALLY INVASIVE EARLY DIAGNOSIS OF ALZHEIMER (ALERT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Germany,Ireland
Call: EIC Pathfinder Open (HORIZON-EIC-2025-PATHFINDEROPEN, 2025)
Start date: 2026-03-01
End date: 2029-02-28
Duration (months): 36.0
Total project cost (EUR): 2917386.25
EU funding (EUR): 2917386.25
Participants: 5
Project status: SIGNED

ALERT introduces a groundbreaking leap in medical diagnostics, redefining in-vivo sensing with a pioneering digital approach. This revolutionary technology centers on multianalyte digital sensing via QR-coded microneedles—engineered for minimally invasive, highly accurate, and real-time measurement of critical disease biomarkers directly from plasma beneath the skin. Seamlessly integrating digital innovation with advanced biomedical sensing, ALERT’s microneedles encode biomarker data into a scannable digital QR code, enabling instant and precise diagnostics. These microneedles operate through a unique binary fluorescence mechanism, switching distinctly "on" or "off" when biomarker concentrations cross predefined clinical thresholds. This digital paradigm eradicates the need for external calibration—a key limitation of traditional analog chemical sensors—ensuring enhanced accuracy, reliability, and ease of use in real-world applications. With a main focus on early detection of Alzheimer’s Disease (AD), ALERT tackles a pressing global health challenge, particularly urgent given the rapidly aging population. AD often remains clinically undetected for 15 to 20 years, making early diagnosis crucial for improving patient outcomes and reducing the immense social and economic burdens of late-stage management. ALERT's approach includes rigorous validation in animal models, well-defined Key Performance Indicators, advanced material synthesis, cutting-edge device fabrication, and proactive risk mitigation strategies. Beyond revolutionizing AD diagnostics, ALERT’s digital QR-code microneedle platform holds vast potential for broader medical applications, including early detection of cancer, sepsis, and infectious diseases. Its adaptability extends even further, with applications in environmental monitoring, precision agriculture, and food safety.

Keywords: digital sensing,digital microneedles,qr code,turn on fluorescence probes,biodegradable,alzheimer,early screening
Shaping intestine epithelium using viscoelastically dynamic matrices (EPIMECH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: SIGNED

Intestine epithelium (IE) compartmentalization and morphogenesis are profoundly influenced by intrinsic biochemical signals and microenvironmental cues in the extracellular matrix (ECM), especially viscoelasticity. Recent studies have revealed substrate mechanical properties have clear influences on intestine stem cell (ISC) fate, IE polarity, self-organization and morphogenesis. However, most of these investigations were performed in constant and static conditions, neglecting the active and dynamic nature of in vivo ECM. Furthermore, whether and how dynamic matrix viscoelasticity contributes to the emergence of symmetry breaking and tissue regionalization in early intestinal morphogenesis remains elusive so far. In this project, we propose to use dynamic hydrogel-based matrices with light-triggerable changes in viscoelasticity to study the transduction of molecular mechanosensing into collective cell dynamics during symmetry breaking and tissue patterning in IE development. We hypothesize that anisotropic substrate viscoelasticity could heterogeneously activate mechanosensing pathways in ISCs and affect ISC proliferation and differentiation, leading to changes in cell activities, sorting and tissue segregation. In brief, with dynamic substrates, we will create viscoelastic patterns/gradients by in situ light patterning and elucidate IE dynamics related to the emergence of cell shape, migration, ISC fate and tissue compartmentalization as functions of the mechanical stimuli. We also aim to identify the molecular principles of IE mechanotransduction, which will improve our understanding of IE development, morphogenesis and homeostasis. The know-how from this project will also enable the fabrication of artificial intestine-on-a-chip devices for further developmental studies. Relying on the multidiscipline approaches, this action will greatly enhance the competence of the researcher as well as bring added value in scientific and societal aspects for the EU.

Keywords: mechanotransduction active mechancial cues dynamic hydrogel tissue mechanics intestinal morphogensis
Development of a boryl radical-mediated H-atom transfer umpolung blueprint to make nucleophilic radicals behave as electrophilic species (BRAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-03
End date: 2026-06-02
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

Aliphatic molecules are integral to every aspect of chemistry and radical chemistry has strong impact in their preparation. However, radical reactions are heavily influenced by the polarity of these species, which ultimately controls their reactivty profile.Most notably, standard alkyl radicals are nucleophilic and therefore do not react with electron rich aromatics and olefins. Electrophilic radicals display strong reactivity with these species but they are of limited synthetic value. This project seeks to address this challenge by developing an innovative approach for radical "umpolung". In particular, we will demonstrate the integration of photoredox catalysis and boryl radical-mediated H-atom transfer catalysis, as a unique blueprint for the activation of alpha,alpha-diborylated alkalnes. This will generate alpha,alpha-diborylated radicals that, owing to their strong electrophilic character, will (i) react with electron rich aromatics and olefins and then (ii) enable diverge functionalization. In this way we will overcome the fundamental issue that nucleophilic alkyl radicals do not react with electron rich olefins/aromatics. This reactivity will streamline the preparation of many high-value but difficult to make aliphatic products, will be used in late-stage functionalizations and will substantially expand the fields of photoredox catalysis and boryl radical chemistry. This research capitalizes on recent developments of the Leonori group that has experience in the design of methodologies based on both H-atom transfer and boryl radical reactivity. The completion of such an innovative and ambitious project at RWTH Aachen University will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my future career following the training plan envisioned.

Keywords: boryl radicals,h atom transfer,radical philicity,radical umpolung,cross couplings