Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A data-driven computational framework to discover how behavior impacts processing in mouse visual cortex (Vision2Action)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 1999633.0
EU funding (EUR): 1999633.0
Participants: 2
Project status: SIGNED

Our movements influence how we perceive the world. Our eyes are attached to a behaving body creating a complex dynamical stream of input that can provide additional information if we know the movement pattern. The interaction between motor and visual signals is especially pronounced in rodent visual cortex that exhibits a substantial, multi-dimensional contribution from motor signals, even in early visual areas. However, a fundamental principle that governs the interaction between visual and motor signals across neurons and visual areas is currently unknown, especially for freely moving animals. I hypothesize that the interaction between visual and motor tuning in mouse visual cortex provide the animal with a consistent and behaviorally beneficial multi-modal picture of its environment. However, studying the interaction between motor behavior and sensory processing is challenging as experiments face a trade-off between experimental control in head-fixed animals (but limited movement) and the availability of rich movement signals in freely moving animals (but limited experimental control). I propose that this trade-off can be bridged by a data-driven in silico neuroscience approach that compiles experimental data into a digital twin that captures the interaction between physiology, motor behavior, internal state, and a model of the environment. The goal of this proposal is to build such an in silico framework to capture the detailed influence of motor behavior on visual processing in freely behaving mice. I will use this framework to discover fundamental organizational principles of the relation between visual and motor tuning across neurons and areas in mouse visual cortex, use them to test computational theories, and develop computational models to quantify their behavioral benefit. This project will not only change our view on the influence of motor signals in visual cortex, but also yield a computational framework with countless applications in neuroscience.

Keywords: visual system digital twin deep learning free behavior system identification virtual environment
Improve Safety in Polymedication by Managing Drug-Drug-Gene Interactions (SafePolyMed)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: Research and Innovation actions
Countries involved: Germany,Greece,Estonia,Netherlands,Slovenia,Finland
Call: Enhancing quality of care and patient safety (HORIZON-HLTH-2021-CARE-05, 2021)
Start date: 2022-06-01
End date: 2026-08-31
Duration (months): 51.0
Total project cost (EUR): 5650444.56
EU funding (EUR): 5650442.81
Participants: 14
Project status: SIGNED

Polypharmacy, multimorbidity and genetic heterogeneity can affect drug efficacy, raise the risk for adverse drug reactions (ADRs) and increase healthcare costs. ADRs are among the leading causes of death in developed countries and a major cause of hospitalization. Drug-drug interactions (DDIs) and drug-gene interactions (DGIs) are highly interconnected and require a holistic approach to improve safety of our citizens. However, investigations on real-life drug-drug-gene interactions (DDGIs) in clinical trials are unfeasible due to combinatorial explosion, high costs and ethical concerns. Hence, significant knowledge gaps exist. Furthermore, the lack of participation in managing their conditions might be excessively demanding for polymedicated and multimorbid citizens. SafePolyMed will develop a novel and innovative framework to define, assess and manage DDGIs for physicians and individual patients resulting in education and empowerment of citizens as well as in reduced healthcare costs by improving patient safety. The main objectives of SafePolyMed are (1) development of a novel, evidence-based risk scoring system using machine learning on large real-world datasets to identify patients at risk; (2) identification and validation of patient reported outcome measures for multifactorial patient safety in collaboration with European patient organizations; (3) development of an electronic tool to empower patients by allowing them to properly manage their therapies, check for and educate about DD(G)Is and collect their patient reported outcomes; (4) mathematical modelling of clinically relevant compounds to derive individualized dose adaptations for safe and effective dose regimens in case of DDGIs, accessible via a web-based decision support system with tailored information for either citizens or physicians and (5) validation of the developed safety tools in a ?proof-of-principle? study including representative patient cohorts from different European clinical sites.

Keywords: adverse drug reactions,polypharmacy,drug drug gene interactions ddgis
Defining the role of the tumor microenvironment in treatment resistance of OVArian cancer through patient-Derived EXplants (OVADEX) (OVADEX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium,Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 2
Project status: CLOSED

Treatment resistance in ovarian cancer (OC) is common. Recent efforts have identified new treatment approaches with potential to improve its management, but their therapeutic effects are limited due to treatment resistances. Tumor microenvironment (TME) is emerging as a key contributor to treatment resistance, being the metabolic cross-talk between TME and OC one of the recently proposed mechanisms. The hosting lab has evidence that platinum-resistant OC cells have defects in serine biosynthesis which leads to an enhance uptake of serine. Importantly, exogenous serine is also required for some TME components, suggesting a possible competition for it and affecting their anti-cancer function. Thus, my working hypothesis is that metabolic cross-talk between TME and OC could involve serine metabolism, which could mediate treatment resistance. Unfortunately, there is a lack of preclinical models of OC that recapitulate TME to study its role. In this regard, the secondment lab developed a new ex vivo platform based on patient-derived explants (PDEs) that allows the study of TME interactions with cancer cells. In OVADEX, I will use PDEs to dissect the role of TME components in treatment response in OC, and particularly, in the metabolic reprogramming of cancer cells. My objectives are to generate OC PDEs and expose them to standard and emerging therapies, to define metabolic changes in OC cells and cellular and phenotypic changes in TME before and after treatment and to associate changes in TME and OC cells to serine metabolism and treatment resistance. To this end, I will integrate innovative techniques and the access of the hosting team to a unique registry of OC patients. Through this work, I aim to broaden my scientific expertise and my international network for pursuing an academic career in Europe. OVADEX will contribute to actualize many objectives outlined in my career development plan to become a PI in the field of preclinical models for cancer applications.

Keywords: oncology,preclinical models,organoids,tumor microenvironment,ovarian cancer,chemotherapy
Political Process Preferences in Europe: Rethinking Conceptual, Ontological and Methodological Foundations (PoPPiE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-04-01
End date: 2030-03-31
Duration (months): 60.0
Total project cost (EUR): 1498930.0
EU funding (EUR): 1498930.0
Participants: 1
Project status: SIGNED

To understand the levels of dissatisfaction with democratic performance in Europe, as well as the most effective reforms for addressing it, requires an understanding of citizens’ process preferences: how do they want democracies to function? Empirical research on process preferences is rapidly proliferating, but it has been underpinned by an assumption that the task of this research is to discover which one of a set of abstract, normative models of democracy citizens subscribe to. The driving idea behind PoPPiE is that this assumption is a serious limitation. It has led the study of process preferences to focus on discrete choices between simple alternatives that fail to represent the real choices facing the inhabitants of complex democratic systems and neglected the extent to which individuals are conflicted between competing democratic norms. It prevents robust inferences on important questions, such as levels of polarisation and support for democratic innovations. PoPPiE develops a groundbreaking new approach to rethink the conceptual, ontological and methodological foundations for researching political process preferences. - First, by applying democratic systems theory to re-conceptualise the content of process preferences it will generate a wholly new conceptual understanding of preferences for complex democratic systems, rather than ideal models of democracy. - Second, instead of assuming that the nature of process preferences is inherently ideological, PoPPiE uses a novel multidimensional theoretical framework to assess levels of contextuality, conditionality and coherence in process preferences. - Third, it develops a new mixed methods approach, producing a unique dataset that combines qualitative and quantitative data on a single individual’s preference. The new approach will not only strengthen the foundations of the science of process preferences, but ensure its findings are more policy relevant for the project of renewing European democracies.

Keywords: political process preferences conceptions of democracy political attitudes democratic systems
Unaccompanied Children’s Access to Healthcare (1945-1950) (UCARE1945)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 252728.64
EU funding (EUR): 252728.64
Participants: 1
Project status: SIGNED

UCARE1945 focuses on unaccompanied minors in Germany in the period 1945-1950, exploring the impact of the postwar experience through institutional accounts, contemporary personal records, and oral history. This will be divided into five case studies per occupation zone (British, French and American, 15 case studies in total) to examine the life experience of individuals. UCARE1945 posits that three major factors affected the immediate needs of unaccompanied minors in the postwar era: gender, age, and social background. In the immediate aftermath of the Second World War, between 42 million and 60 million people were displaced. Children witnessed atrocities and lost family members, leaving thousands of children without a wider kinship network. Displaced persons camps, and international organisations such as the UNRRA (United Nations Relief and Rehabilitation Administration) and the IRO (International Refugee Organisation) had three main objectives – document the displaced population, find accommodation, and provide much needed healthcare. The aim is to analyse the impact of healthcare crises in the aftermath of the Second World War, and to understand how differences in state policies and practices impact the experiences of unaccompanied child refugees. In post-WWII Europe, access to emigration and compensation was mediated through medical care; doctors were tasked with verifying the health of survivors before they were granted emigration papers, and attesting to medical harm when claiming compensation for unethical experimentation during the war. Many doctors continued to hold antisemitic views and anti Sinti and Roma bias after the war. In the years following the war, many Nazi doctors continued to practice medicine and their perceptions of the ‘worth’ of patients continued to impact the care they provided. UCARE1945 will question how governmental policies and institutional actors impacted childrens' access to care.

Keywords: history of the holocaust,postwar histories,history of migration,history of medical care,histories of childhood
Accelerate the design and Insertion of nonCRM hard Materials for Next generation EXTreme applications (AIM-NEXT) (AIM-NEXT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Sweden,Ireland,Germany,Portugal,Liechtenstein,Italy,France
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-02-01
End date: 2028-01-31
Duration (months): 48.0
Total project cost (EUR): 2802224.57
EU funding (EUR): 2679444.0
Participants: 15
Project status: SIGNED

The AIM-NEXT project arises from the common need of European academy and industry to educate and train the next generation of experts in the field of “Sustainable design of material solutions for engineering applications”. In this regard, the need to Accelerate the design and Insertion of hard Material tools and components, manufactured using non-critical raw materials, for Next generation EXTreme applications has been identified as an area of strategic economic and environmental importance for the European Union, where accordingly the skills developed by the doctoral students are adapted to the current and future industrial needs and the ongoing transformation towards more sustainable production processes. To address this need, a coherent international, interdisciplinary, and intersectoral training and research programme has been developed involving a selection of some of the best European Universities in the field together with worldwide leading Industrial organisations covering fundamental elements of the product value chain in key industrial sectors (i.e. mining, manufacturing and construction engineering). By participating in the AIM-NEXT project, the 10 Doctoral Candidates will receive: (i) top level interdisciplinary training through a defined scheme where each fellow is exposed to all three technical environments; (ii) intersectorial training articulated through a wide variety of strategic research themes and the different application areas represented in the consortium; and (iii) international training through a portfolio of mandatory network-wide training events and secondments at academic and industrial partners. Thus, the combination of technical and transferrable skills acquired by the fellows through technical training, interdisciplinary research and industrial exposure will enhance their employability and open up solid career opportunities to them, particularly within a field where skilled PhD engineers are currently an extremely scarce resource.

Keywords: hard materials,non critical raw materials,extreme applications
Marine Munition in Europe - Solutions with Economic and Ecological Profits for Efficient Remediation (MMinE-SwEEPER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Border Management
Action type: Research and Innovation actions
Countries involved: Germany,Denmark,Poland,Belgium,Norway,France,Spain,Finland,United Kingdom,Italy
Call: Identify, inspect, neutralise Unexploded Ordnance (UXO) at sea (HORIZON-CL3-2023-BM-01, 2023)
Start date: 2024-10-01
End date: 2028-03-31
Duration (months): 42.0
Total project cost (EUR): 6437283.95
EU funding (EUR): 5916095.56
Participants: 22
Project status: SIGNED

The MMinE-SwEEPER project will advance knowledge, capability and capacity in Europe for dealing with marine munition in the non-military aspect of UXO-clearance. 21 partners from 7 EU and 2 associated countries bring experience and capabilities from the civil science community (9), military research (3), coast/border guards or EOD-services (4) as well as industry (3) and intergovernmental organizations (2). Jointly they will work in 8 technical work packages to a) advance automated munition detection, identification and data analyzing technologies and software, b) environmental monitoring of chemical contaminants, c) predictions of UXO-burial, contaminants spread and the state-of-corrosion, and will d) enable secure exchange of sensitive data (64% of person months). Three additional WPs will compile existing knowledge, learn about the legal responsibilities and technical approaches, assess remediation and mitigation measures and create training material for building European capacity (14% PM). Two WPs will engage in an intense stakeholder dialog and dissemination/outreach activities by utilizing capacities already existing at HELCOM and JPIO (14% PM). Outcomes with respect to specific technical advancements will include a) AI-supported detection of munition in hydroacoustic spatial mapping data (MBES, SSS; SAS), b) detection of buried munition objects (magnetic, SBP, LF-SAS), c) AI-supported object identification in optical and acoustic cameras and d) implementing trained AI-models into Smart-AUVs and -USVs for adaptive and cooperative mission execution. All this will utilize secure data exchange possibilities through a demonstrator data platform that will be refined during the project. Industry partners see a great benefit in developing technologies that later can be advanced further to become commercial products. At the end of the project most TRLs will be at 5 to 6, meaning they have been applied under real conditions and proved their applicability.

Keywords: hydroacoustic seafloor mapping,optical object detection,ai supported data analyses,smart robots,secure data exchange,knowledge compilation,training and capacity building,stakeholder co design
Bounds On Numerical Syzygies And Invariants (BONSAI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

The BONSAI (Bounds On Numerical Syzygies And Invariants) project is aimed at investigating relations among generators and invariants of numerical semigroups and the rings associated to them, through theoretical and computational means. We consider a set of problems involving bounds for the Betti numbers of numerical semigroup rings, focusing on the first and last Betti numbers, which can be deduced from combinatorial data of the numerical semigroup.

Keywords: numerical semigroups commutative algebra syzygies betti numbers
3D tab cooled Battery pack solution based on an innovative 3D extrusion manufacturing process to better manage thermal regulation of EV batteries (Reliefed)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-01-01
End date: 2025-11-30
Duration (months): 35.0
Total project cost (EUR): 3997004.76
EU funding (EUR): 2500000.0
Participants: 1
Project status: SUSPENDED

The main requirements for any Electric Vehicle (EV) battery are performance, safety, sustainability, and financial viability. Significant deviations from ambient conditions can lead to reduced performance, accelerated degradation and thermal runaway. Thermal management systems are crucial to lower degradation rates for the lithium-ion cells in operation, and therefore to increase battery pack lifetime. Surface cooling approach for thermal management dominates the EV market, yet published research suggests lithium-ion cell lifetime can be tripled if tab cooling is effectively implemented in the battery pack design. Reliefed has developed a disruptive 3D-iExtrusion manufacturing technology that allows, for the first time, to produce tab cooled battery packs, delivering higher charging rates and lower costs while increasing lifetime and safety. To commercialise such a disruptive technology, Reliefed needs the help of the EIC to finish optimising and validating the tab cooled battery pack.

Keywords: battery recycling,ev safety,tab cooling module,battery pack,3d extrusion manufacturing,electric vehicles