Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Efficient Organic Photovoltaic Sensors (EFFECTOR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: France,Denmark,Belgium,Finland,Switzerland
Call: Low-power PV (HORIZON-CL5-2024-D3-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 3606133.94
EU funding (EUR): 2972693.34
Participants: 10
Project status: SIGNED

The project Efficient Organic Photovoltaic Sensors (EFFECTOR) will deliver innovative and environmentally-friendly solutions for digital and wearable electronics at TRL7. These objects will be individually powered by harvesting low-level light and will be made from sustainable materials for a bright digital future. EFFECTOR will contribute to a strategic position through an open economy in the key digital, and human-centric emerging technology by developing highly sustainable energy harvesting under diffuse, low-light conditions in the key areas of security and health. EFFECTOR will create new sustainable European value chains for photovoltaic technologies and open new innovative business-to-business operations by doubling the efficiency of non-toxic organic solar cells for use under low-level light. It will couple in a streamline way with non-toxic, sustainable supercapacitors with advanced low power electronics. The EFFECTOR strategy is to bring solar cell technology to mainstream use by eliminating the need for mains electricity from everyday human-centred electronics. It will develop sustainable materials and processes, using non-toxic materials and reducing environmental impact applicable for a huge raft of human-centred technologies and innovations. EFFECTOR draws on the world-leading inkjet OPV manufacturing of Dracula Technologies, the sustainable non-toxic aqueous supercapacitors of Innocell, and the high fidelity power management systems from e-peas. With its world-leading academic partners in solar cell design (SDU), high throughput industrial electronic printing and integration (VTT) and polymers for solar cell stabilization (CNRS), it will demonstrate this innovative multi-faceted approach in vital health monitoring with Polar and portable device applications with CardLab’s biometric card technology. EFFECTOR will demonstrate how low-level and indoor light can power our future in a secure, reliable and sustainable way.

Keywords: organic solar cells,low power,supercapacitor,security,health,high efficiency
A new technology to probe molecular interaction in cells at high throughput (DiffusOMICS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-04-01
End date: 2025-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Protein oligomers and aggregates are pillars of many cellular processes and can be associated with a number of life-threatening neurodegenerative diseases. These processes are often context-dependent but are hard to detect in situ with available technologies. The ideal instrument can target specific proteins of medical interest in their physiological contexts, resolve nano-distances (1-100 nm) and capture dynamics of association and dissociation (ns-ms). The DiffusOMICS project aims to fill this methodological gap by prototyping a high-throughput fluorescence-based approach able to measure the rotational diffusion properties of molecules in vivo and in situ. The concept is based on our recent publication, where we utilize intelligent fluorescent probes together with polarized light to investigate the rotational dynamics of large molecular complexes. Rotational diffusion is highly sensitive to change in mass making the technique ideal to detect the presence of aggregates and report on molecular size and local viscosity. Due to the nature of the signal, the measurements can be done in cells and tissues at high throughput, making the technology appealing for industrial screening applications. The goal of the project is to establish both the technological foundation and the collaborations needed to develop a prototype instrument and to record the very first high-throughput molecular interaction maps in neurons. DiffusOMICS possesses all the essential qualities to become a game-changing technology for drug screening due to its sensitivity, specificity and speed, making it suitable for automated recordings. DiffusOMICS maps will carry information on the whole population of aggregates localized in different neuronal compartments and can track changes in aggregation responses to drug perturbations and mutagenesis in neuronal proteins. The outcome will be key to engage industrial strategic partners and it paves the way for a new paradigm of drug screening in situ.
The elusive role of physicality in virtual trials: Towards a new understanding of legal participation (VIRTUTRIALS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Video links are widely used in courtrooms across the globe but there is a mounting apprehension that the legitimacy and fairness of trials are threatened by the diminishment of physical interactions this format entails. The problem addressed in VIRTUTRIALS is that current concerns regarding the threat video links pose to trials by diminishing physical interaction may not be substantiated by contemporary examination. Instead, these concerns may originate from a fetishization of physicality, despite physicality remaining an enigma. Given the centrality and importance of trials in democratic societies, this has important implications for legal security and the continued trust in the legal system. It is especially critical considering the impending shift to virtual reality trials devoid of physical presence. VIRTUTRIALS will identify how physicality and the absence thereof shapes contemporary trials and participation within in order to show if and how trials can retain their legitimacy and fairness in virtual settings. The state-of-the-art pinpoints three interlinked themes regarding physicality which inspire the research questions: RQ1: How does participation format shape participants’ accomplishment and experience? RQ2: What are the social ingredients of virtual justice rituals? RQ3: How are displays of credibility and remorse understood and evaluated in physical versus virtual trials? VIRTUTRIALS has an innovative abductive and interconnected design using a multi-methods approach, including ethnography, qualitative interviews, and a combined qualitative and quantitative analysis of written judgements. By uniquely drawing on a social scientific perspective with interactionist theory, it aims to analyse and challenge the current understanding of trials as face-to-face interactions. In today’s rapidly digitalising world, where interactions in virtual settings are progressively prevalent and intricate, VIRTUTRIALS contributes vital knowledge on virtual interactions.

Keywords: video links,physicality,virtual participation,emotion,ritual,interactions,trials,practices
MEDITERRANEAN RESEARCHERS' NIGHT (2024 AND 2025 EDITIONS) (MEDNIGHT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Italy,Greece,Spain,Cyprus,Türkiye,Belgium,France,Tunisia
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-03-08
End date: 2025-12-07
Duration (months): 21.0
Total project cost (EUR): 721375.83
EU funding (EUR): 674236.0
Participants: 14
Project status: SIGNED

More than 500 million people on three continents are united by the world's largest sea, the Mediterranean. Our strategic geographic location and shared history gives us a common character as well as common challenges. The objective of Mediterranean Researchers' Night - MEDNIGHT is to generate Mediterranean unity, providing awareness about common problems, fostering scientific careers, reinforcing researchers’ commitment and progress, and putting science and scientists at the cornerstone of our future. MEDNIGHT shows the attractiveness and importance of the researchers’ work and professions to the general public, with a focus on young people, carrying out a series of activities framed under the common umbrella of what we have come to call Mediterranean Science, a source of progress and well-being. Mediterranean Science relates to research developed in our territories but also the countless collaborations with other EU researchers. Mediterranean Science is focused on Mediterranean relevant topics according to our culture, way of life or current challenges: History and Heritage, Life and Health, Diet and Nutrition, Sea and Pollution, Climate and Clean Energies, Geology and Biodiversity, Technology and Future. Many online and face-to-face diverse activities will be organised by MEDNIGHT consortium in Messina, Lesvos, Xanthi, Nicosia, Istanbul, Brussels, Monastir, Montpellier, Toulouse, Madrid, Almeria, Orihuela and Tabarca (Main cities) but also Athens, Patras, Limnos, Rhodes, Syros, Eyupsultan, Kadikov, Guardamar, Torrevieja, Santa Pola, Nantes, Larnaca among others. The evolution, expansion and at the same time consolidation of the pillars of MEDNIGHT are being clear, with partners from eight different countries: Spain, Greece, Italy, France, Cyprus, Turkey, Tunisia and Belgium. All together they give solidity to the brotherhood between Mediterranean countries around the culture of science, as opposed to the conflicts that occur in our Mediterranean

Keywords: mediterranean science,scientific vocations,engagement,gender gap,scientific communication
Reshaping the nucleome to reveal its gene- and mechano-regulatory function (RENOME)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1998595.0
EU funding (EUR): 1998595.0
Participants: 1
Project status: SIGNED

The content of the cell nucleus is highly organized at different levels. Chromatin is partitioned into domains that carry different post-translational histone modifications, and it exhibits a multiscale structural organization from small loops to large compartments. Nuclear RNAs and proteins recognize cues on chromatin, forming different types of chromatin-associated complexes and condensates. The nucleus as a whole is the largest and stiffest organelle of the cell and modulates its mechanical properties. Dysregulation of the nucleome at any level goes along with altered gene- and mechano-regulation in diseases such as metastatic cancers. Currently, the functions of the different organizational levels of chromatin, their mutual relationships and the impact on cellular phenotypes are poorly defined. Progress in this field has been hindered by several technical limitations. One is the inability to study chromatin folding in single living cells, which would allow to interrogate its dynamics, to assess its response to perturbations in real-time, and to relate it to the mechanical properties of the same cell. Another limitation is the lack of tools to selectively reengineer different levels of the nuclear organization to test their function. With the RENOME project, I propose to overcome these limitations by developing systems to study chromatin compartments in real-time and to reshape different organizational levels of the nucleome in a tunable manner. These tools will make it for the first time possible to define the functional impact of nuclear organization across scales, from single molecules to mammalian cultured cells and 3D organoids. RENOME links chromatin regulation, phase separation and nuclear mechanobiology, with the goal to connect molecular mechanisms to cellular behavior. By providing a multi-scale predictive model for the organization of the nucleome and a toolbox for its reengineering, it will lay the groundwork for future epigenetic therapies.

Keywords: chromatin organization chromatin condensates histone modifications nuclear mechanics
Spatio-temporal dynamics of immune circuitry in glioblastoma: from single cells to comprehensive models of tumor niches (STIC-GBM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: SIGNED

Glioblastoma (GBM) is the most lethal brain malignancy in adults and is associated with a poor prognosis. Therapy options in GBM patients are largely limited by the highly immunosuppressive tumor microenvironment (TME). Identifying and disrupting these immunosuppressive communication circuits between immune cells and the tumor is key to reinvigorate the immune system’s ability to fight the tumor. Here, we combine my previous experience in the analysis of single cell data at the neuro-immune interface with Prof. Zeiser’s patient-centered expertise in developing novel therapy options to combat tumor immune escape. In this highly complementary setting, we propose a data-driven approach to trace and perturb inhibitory communication circuits elicited by the TME across space and time with the aim to discover novel immunotherapeutic targets in GBM. Using a novel temporal single cell technology, we will 1) assemble a multi-layered spatio-temporal single cell roadmap to characterize and model how individual immune cells are affected by the TME in a murine model of GBM. 2) We will develop a computational framework for spatial transcriptomics to dissect single cells into niches defined by similar interaction programs with neighboring cells. 3) Using this tool, we will quantify the niche organization in human patients and identify ligand-receptor interaction pairs crucial for niche maintenance. 4) Candidate genes will be genetically ablated in either the tumor or the immune compartment and evaluated with regards to their in vivo efficacy in suppressing tumor growth. Our cutting-edge analytical pipeline from the identification of driver molecules for immune escape to the assessment of in vivo efficacy in a preclinical model of GBM will reveal novel targets for treatment. Our study thereby works directly towards the Horizon Europe Mission to understand, treat and beat cancer.

Keywords: glioblastoma,immunotherapy,single cell genomics,systems immunology,tumor microenvironment
GlycoRoads: A platform for the de novo design of glycans (GlycoRoads)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-06-01
End date: 2026-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

In the spirit of the various in silico de novo protein design products, GlycoRoads aims to introduce the world's first tool for de novo glycan design. Our cutting-edge screening platform will harness the power of molecular dynamics (MD) simulations to analyse hundreds of thousands of glycan structures, extracting crucial structural information to populate a comprehensive database (DB). This rich repository of data will serve as the foundation for an AI-driven user interface, designed to interrogate the DB and guide the de novo design of glycans that can adopt specific target conformations, greatly accelerating the exploration of their applications. The growing recognition of glycans' critical roles in biology and materials science underscores the transformative potential of our project. If successful, it will unlock unprecedented capabilities to customize glycans for targeted applications, opening new avenues in the design of next-generation therapeutics and materials. Within the ERC GlycoFold grant, our team has designed glycans with precise secondary structures. GlycoRoads builds on this groundwork to make the strategic design of glycans accessible to both academic and industrial researchers. This goal requires the completion on three critical objectives: I) Enhancing the current MD-based screening platform, II) Generating and systematically cataloguing a vast array of data into a comprehensive and accessible DB, and III) Developing an AI tool to leverage the DB to accelerate the design of glycans for diverse applications. The anticipated outcomes of our project—a detailed DB of glycan structures and a user-friendly interface for its interrogation—offer substantial commercialization prospects. Together, they pave the way for a groundbreaking shift in de novo glycan design across various fields.
Subaltern Workers, Labour Relations, and Empire Building in the Portuguese Estado da Índia (1510-1663) (EMPIRELAB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-08-15
End date: 2027-08-14
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: SIGNED

How and to what extent did 'free' and unfree non-European labour contributed to build and sustain the Portuguese Asian empire during the 16th and 17th centuries? This is the main question I will address in this project, by exploring the case study of the Estado da Índia (henceforth EI) between 1510 and 1663. The main hypothesis I want to test is that the EI was able to develop and sustain itself (even in times of decline) due to a highly intensive extraction and allocation of non-European labour, especially when compared with other European counterparts in the Indian Ocean, namely the Dutch and the English. This project dialogues therefore with a wider trend in the historiography that analyses the importance of the populations under European imperial dominion for empire building and economic development, especially in what concerns non-European capital, natural resources, and labour. The allocation of labour in colonial settings was noticeable in many dimensions of the everyday life. This project will focus on three intertwined locus of observation: the military, the urban and the rural labour markets. By gathering evidence from European and Asian archives, building and testing a dataset on occupational structures and labour relations in the Portuguese EI, EMPIRELAB will offer a first insight in labour dynamics in Portuguese Asia. The findings of EMPIRELAB will provide historians of the European and non-European empires with comparative data and an innovative perspectivein order to feed larger debates both in academic and non-academic contexts regarding the impact of colonialism in our societies. It will raise awareness about labour and migration in historical perspective, thus helping to overcome established preconceptions about the relevance of labour for imperial history. Moreover, it will contribute to an improved assessment of the origins and maintenance of inequalities in the early modern colonial period.

Keywords: urban labour rural labour military labour markets occupational structures labour relations indian ocean resistance negotiation subaltern studies eurasian early modern empires
Exploring multitrophic interactions of defensive insect symbionts at the community level (SymbioDef)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: SIGNED

Many animals acquire new abilities after establishing a symbiotic interaction with a microorganism, and the last decades have revealed the prevalence of defensive symbioses between animals and microorganisms. One of the best-studied cases are aphids that engage in a symbiotic relationship with a facultative bacteria that protect them against parasitic wasps (parasitoids). Parasitoids are small wasps that reproduce by injecting an egg as well as toxic venom compounds into their hosts, ultimately killing the host upon parasitoid development to adulthood. Defensive symbionts, however, can challenge this process and reduce parasitism success, a process that can alter the efficiency of biological control programs against aphids. While aphid defensive symbionts have been well studied in the past two decades, there is still no direct evidence of the defensive mechanisms against parasitism. Particularly, the interaction between aphid symbionts and parasitoid venom remains unexplored. In addition, studies have focused on the direct effects of symbionts on parasitoid populations, but complex indirect effects on the entire community of aphid natural enemies have been largely overlooked. In this multidisciplinary project, I propose to fill these gaps in knowledge by 1) unravelling the interaction between parasitoid venom and aphid symbiont protection, 2) investigating the indirect effects of aphid symbionts on the insect community of natural enemies and 3) regrouping these themes in a meta-analysis of the scientific literature to empirically assess the effects of insect microbial warfare. This proposal will advance our fundamental understanding of the effects of aphid symbionts, and it will be of applied interest to improve aphid biocontrol.

Keywords: intraguild predator defensive symbiont parasitoid aphid venom