Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
IBI-AG: NEXT GENERATION BIOCONTROL FOR FOOD PROTECTION (IBI-AG)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2450000.0
EU funding (EUR): 2450000.0
Participants: 1
Project status: SIGNED

IBI-Ag is a pioneering agri-biotech company, dedicated to revolutionizing the agricultural sector by providing sustainable and innovative bioinsecticides. The company's proprietary technology platform leverages nano-bodies, a type of antibodies, to develop effective, selective, and safe biological insect control solutions. The problem lies in the substantial loss of produce worldwide due to pests, with an estimated loss valued at €65 billion globally in 2022. The prevalent use of chemical pesticides, while beneficial in the short term, carries significant disadvantages including environmental contamination, development of pesticide resistance in pests, and potential health risks to humans. IBI-Ag's innovative solution addresses these issues by offering an environmentally friendly, cost-effective alternative to chemical pesticides. Their unique platform generates selective bio-insecticides using single-domain antibodies (SDA) or nanobodies, marking the first instance of insecticidal activity using antibodies. This breakthrough technology has the potential to revolutionize the agricultural industry by providing an effective and safe solution to pest control. The global bioinsecticide market, which IBI-Ag operates within, was valued at €2.6B in 2022 and is expected to reach a value of €5.5B by 2027. With the European Union's Farm to Fork strategy setting a goal of 50% reduction in chemical pesticide use by 2030, IBI-Ag's nanobody-based bioinsecticides provide an ideal solution to meet this target.

Keywords: bio insecticides,biopesticides,single domain antibodies,integrated pest management
SCALE-UP OF A PIONEERING STEM CELL DERIVED PRODUCT TO ENSURE READINESS IN A CLINICAL TRIAL FOR NECROTISING ENTEROCOLITIS (CELL3-4NEC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2499000.0
EU funding (EUR): 2499000.0
Participants: 1
Project status: SIGNED

Micregen has an ambitious goal to establish a new class of therapeutics that address inflammatory and degenerative conditions. We are focused on developing several novel stem cell-derived secretome therapeutics, collectively referred to as Secretomix®. The secretome is the set of molecules and biological factors that are secreted by cells into the extracellular space and have great un-tapped potential as novel therapies. Our initial disease focus is on Necrotising Enterocolitis (NEC), a devastating and life-threatening condition, which is an area of high unmet clinical need, where there have been no new approaches for decades. Characterised by intestinal necrosis (unprogrammed cell death), the disease can lead to intestinal perforation, sepsis and multi-organ failure. Our first product under development, MRG1061 is a highly innovative biologic that has potential to be a first-in-class therapeutic of a new class of cell-derived Secretomix® therapies for paediatric conditions. Rather than utilising whole stem cell regenerative therapies, which are often found to have significant limitations and a variety of known risks, our research is focused on development of mesenchymal stem cell-derived secretomes. This novel cell-free-based secretome approach is hoped to reduce complications associated with whole cell transplantation. Our pre-clinical data on MRG1061 is highly promising as a new way to safely treat NEC, and related conditions, in an anti-inflammatory and regenerative manner. However, as a novel cell-derived therapy there are a number of challenges that need to be overcome to scale its manufacture. Our proposed EIC Accelerator project, called CELL3-4NEC, will seek to overcome these remaining manufacturing scale-up challenges to ensure readiness for a phase 1/2a clinical trial, thereby unlocking the full potential of our Secretomix® science and ensure we can treat these high unmet need patients.

Keywords: inflammatory and degenerative conditions regenerative therapy stem cell derived therapy secretome necrotising enterocolitis paediatric conditions biologic gmp manufacture
Increasing reproducibility through the co-creation of interventions that support a transparent and trustworthy research ecosystem (TRUSTparency)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Norway,Denmark,United Kingdom,Netherlands,Latvia,Greece,Finland,Brazil,Philippines,Ghana,Ukraine
Call: Support to the development and implementation of policies and practices for reproducibility of scientific results (HORIZON-WIDERA-2024-ERA-01, 2024)
Start date: 2025-02-01
End date: 2028-01-31
Duration (months): 36.0
Total project cost (EUR): 1999958.25
EU funding (EUR): 1999956.5
Participants: 13
Project status: SIGNED

TRUSTparency starts from the assumption that what scientists need to trust is that the Mertonian process of organised scepticism can operate, allowing scientific knowledge to self-correct efficiently. By extending this assumption we argue that scientists and all other research stakeholders should be open to adopt innovative interventions, to the extent that they can trust that these are developed, deployed, assessed, and corrected transparently and collaboratively. TRUSTparency’s core guiding principle clearly reflects the above argument, specifically by advocating for a maximally informed, context-sensitive, collaborative, democratic, and transparent approach to facilitating the development of interventions that enhance reproducibility by Research Performing Organisations, Research Funding Organisations, learned societies, and publishers. These types of institutions will be empowered to develop their own policy guidelines in the form of a Reproducibility Promotion Plan (RPP), which will be a sequence of concrete steps to transfer the practices that promote reproducibility to their everyday work and to monitor their effectiveness with mechanisms customised to their specific needs. The co-development activities of the project will be based, with the concerted engagement of the project’s Stakeholder Advisory Board (SAB), which is composed, among others, of 10 national Reproducibility Networks (RNs). The SAB will actively participate in the three-stage co-development plan of the project’s interventions: (a) development, (b) pilot testing by 9 institutions, and (c) validation-finalisation. The project's co-creation activities will be applied in tandem with a wide and structured discussion facilitated by the highly innovative comCensus platform. From day one, TRUSTparency will establish a Reproducibility Community and invite all stakeholders with stakes in fostering reproducibility to join through an open call distributed via the professional networks.

Keywords: reproducibility,reproduction,replication,metascience,interventions
Center for Digital Text Scholarship (DigiTS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Panel: Social Sciences and Humanities
Countries involved: Estonia
Call: ERA Chairs (HORIZON-WIDERA-2023-TALENTS-01, 2023)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 2499692.97
EU funding (EUR): 2499692.97
Participants: 1
Project status: SIGNED

Rapidly expanding developments in computational methods and capacity in recent decades have significantly and sustainably changed the opportunities that Humanities disciplines have at their disposal to carry out effective investigations using text-based data. This subfield of Digital Humanities research is particularly relevant for linguistics, literary scholarship, folkloristics and history, and yet relevant modern methodologies for computational approaches to processing textual data for Humanities research are often practiced and taught in a fragmented, individualistic way. The very recent arrival of generative AI and LLMs promises even more opportunities, but these uncharted waters are still waiting for exploration and potential exploitation in the Humanities, especially concerning smaller, less-supported European languages. This ERA-Chair project will permanently improve this landscape in Europe by creating the Center for Digital Text Scholarship – DigiTS – as an interdisciplinary pocket of excellence at the University of Tartu in Estonia for applying cutting-edge computational methods in text-based Humanities research at the European periphery. Prof Maciej Eder, a renowned expert in expert in computer-assisted text analysis, will lead DigiTS and its international interdisciplinary team in carrying out world-class Humanities research using established and novel methods in neural networks and data analyses for exploring textual data. In addition, the team will teach the next generation of Estonian and other European Humanities scholars in these methods at BA, MA and PhD levels, and also consult DH researchers at all levels. Simultaneously, the center will promote the creation and application of LLMs for Estonian, as an exemplary smaller European language. These activities, combined with collaboration with Humanities researchers in other institutes and consortia, will ensure that UTARTU becomes synonymous with text-based Digital Humanities research.

Keywords: digital humanities,distant reading,cultural evolution,computational stylistics,stylometry,natural language processing,language resources,under resourced languages,large language models
Advanced Anaerobic Reactor for High Hydrolysis and Conversion Efficiency in Sewage Sludge Treatment (HYCO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium,Denmark,France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2027-10-31
Duration (months): 24.0
Total project cost (EUR): 200400.0
EU funding (EUR): 200400.0
Participants: 3
Project status: SIGNED

The HYCO project tackles the growing challenge of sustainable sewage sludge management, a critical issue for wastewater treatment plants (WWTPs) in the EU, which produce 10-13 million tons of dry sludge annually. Current sludge treatment methods, particularly anaerobic digestion (AD), suffer from inefficiencies like slow reaction rates and high disposal costs. HYCO aims to revolutionize AD with the development of a novel compartmentalized plug-flow reactor (CPFR). By integrating advanced microbial process optimization, H2 addition for CO2 fixation, and innovative feeding strategies, HYCO will double hydrolysis rates, improving sludge treatment efficiency by over 50%. This will significantly reduce sludge disposal costs and enhance renewable methane production. This project builds on my PhD and postdoctoral work at TU Delft, where I deployed cutting-edge metagenomic techniques and innovative feeding strategies to boost microbial activity and eliminate harmful pretreatment processes. At KU Leuven, I will collaborate with Prof. L. Appels, who specializes in optimizing AD treatment processes and developing AD reactors. Her expertise, combined with two secondments at Aalborg University and INRAE and two industrial stays at Aquafin and Waterleau, will further drive interdisciplinary advancements in microbiology, process engineering, and AI modeling. HYCO will deliver a cost-effective, environmentally friendly solution for sludge management, contributing to the circular economy and the EU’s energy transition goals. By reducing waste, increasing methane yields, and improving reactor performance, HYCO aligns with sustainability objectives, offering a scalable approach for WWTPs across Europe. The project's impact extends beyond technological innovation, supporting local energy grids, reducing greenhouse gas emissions, and promoting sustainable urban waste management.

Keywords: anaerobic digestion,sewage sludge,plug flow reactor,protein sip,ai modeling
Theranostic Peptide Tracers for Breast Cancer (Peptide Tracers)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-04-01
End date: 2026-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Breast cancer impacts one in eight women globally, resulting in over half a million deaths each year. Current diagnostic methods fall short, with ~40% of breast cancers having already spread at the time of diagnosis and mammography often producing high rates of false positives. Additionally, there is a lack of reliable tools for monitoring treatment responses, tracking recurrences, or providing real-time tumour visualisation to aid surgical tumour removal. This project addresses these challenges by developing theranostic peptide tracers targeting the oxytocin receptor (OTR), a promising new target for imaging, diagnosis and treatment of breast cancer. OTR is highly overexpressed in primary breast cancers, including metastatic and triple-negative cases, which remain difficult to treat. Our team has successfully developed potent, OTR-specific peptide tracers capable of visualising OTR in cells and tissues. Building on this progress, the project will refine and expand the design of these tracers and provide proof-of-concept data that they can be used to efficiently visualise and remove breast tumours. Expected outcomes include theranostic tracers that can enhance breast tumour detection, support breast-conserving surgical tumour removal, and targeted radiotherapy, including subtypes that currently do not have targeted approaches. This combined approach of improved detection and targeted therapy has the scope to considerably enhance patient care, treatment options, and survival rates while reducing healthcare costs. The development of these tracers, supported by preclinical data and intellectual property protection, is expected to attract further investments and foster industry partnerships to accelerate clinical translation.

Keywords: peptide tracers,theranostics,cancer,pharmacology,medicinal chemistry
Systems of Transmitting Early Modern Manuscript Verse, 1475–1700 (STEMMA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Ireland
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 1864593.0
EU funding (EUR): 1864593.0
Participants: 1
Project status: SIGNED

STEMMA offers the first large-scale quantitative analysis of the circulation of early modern English poetry in manuscript between 1475 and 1700. It addresses a significant gap by developing innovative computational methods for studying the social and material forces that informed literary culture. Scholars have tended to address individual manuscripts as case studies. In contrast, STEMMA revolutionizes the study of manuscript poetry by taking a data-driven approach to identify patterns and trends at scale. At its centre is the poet John Donne, whose reluctance to circulate his verse makes the survival of at least 4,249 manuscripts of his work all the more puzzling; the poems of his next most-circulated contemporary survive in fewer than 1,000 witnesses. To understand how Donne’s poems, and early modern poetry more generally, circulated throughout the English-speaking world, the project synthesizes six of the most comprehensive datasets about early modern manuscripts and applies insights from social network analysis and graph theory to model the larger transcontinental communications system. The project’s objectives are to provide the first comprehensive study of early modern English manuscript verse circulation; to combine, augment, and enrich the most important bibliographical datasets and return them as Linked Open Data; to develop transferable and extensible methods for analysing the circulation of manuscript poetry; to offer a thoroughly revised account of the production and circulation of literary manuscripts after the introduction of print; to provoke a reassessment of historical metanarratives that privilege print and obscure the diverse agents who participated in early modern literary culture; and to facilitate new modes of research and discovery. The project offers benefits for scholars of early modern Europe as well as those working on computational and digital projects addressing a range of time periods, national traditions, and disciplinary orientations.

Keywords: early modern literature early modern poetry sixteenth century literature seventeenth century literature english literature manuscript studies computational methods quantitative methods digital humanities social network analysis historical network analysis
Modular laser sources for sustainable production of short personalized production series (WAVETAILOR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Photonics (co-programmed)
Countries involved: Austria,France,United Kingdom,Spain,Italy,Germany
Call: High-precision OR complex product manufacturing – potentially including the use of photonics (Made in Europe and Photonics Partnerships) (IA) (HORIZON-CL4-2023-TWIN-TRANSITION-01, 2023)
Start date: 2024-01-01
End date: 2027-06-30
Duration (months): 42.0
Total project cost (EUR): 4898243.82
EU funding (EUR): 4090265.34
Participants: 11
Project status: SIGNED

WAVETAILOR focuses two industrial scenarios which are related to the complex multi-material component and assembly. The first one is Directed Energy Deposition of a multimaterial leading edge for a hypersonic hydrogen-driven airplane, while the second relates to the Powder Bed Fusion of complex multi-material assembly of a drone for urban delivery. The challenges in both cases are related with zero-defect manufacturing, sustainability and first-time-right manufacturing. WAVETAILOR aims to solve the high-precision in complex material structure manufacturing, the disassembly, reuse and recycling of components, while reducing the environmental footprint of both manufacturing process and the components itself. To achieve this, three main pillars are developed in the project: 1) flexible energy efficient photonic setup based on modular diode-based laser source and multi-wavelength optics; 2) full reconfigurability of this setup, to use minimal energy and material resources in manufacturing of two use cases and 3) ZDM and ZDW strategies at assembly level controlling the compliability of complex multimaterial products at machine level, shop floor level and delocalized manufacturing chain level. The latter pillar will be based on digital sibling (shop floor level) and twin (cloud level) for automatic assessment of component/assembly design for circularity; first-time right process planning using synthetic legacy data and ZDM/ZDW based on real time process and post-process monitoring. When the WAVETAILOR objectives are achieved, the manufacturing process of the two use cases will have spent 200MWh of energy less, 923kg of waste less, while the production costs are going to be 50-65% lower. In order to prove this a dedicated sustainability study is provided along the project.

Keywords: digital twin redesign for sustainability,first time right multi material energy efficient production
Planning Regional-Scale Multimodal Operations for Innovative Air Mobility Services (PRIAM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Spain,Belgium,Italy,France
Call: ATM Excellent science and outreach for multimodality and passenger experience (HORIZON-SESAR-2023-DES-ER-02, 2023)
Start date: 2024-09-01
End date: 2027-02-28
Duration (months): 30.0
Total project cost (EUR): 999625.0
EU funding (EUR): 999625.0
Participants: 8
Project status: SIGNED

PRIAM’s vision is that, within the next decade, regional-scale IAM services will be part of the European MaaS ecosystem, helping address regional connectivity challenges. Decisions on IAM will be supported by digital twins, powered by mobility data spaces and AI tools. IAM services will create sustainable value for aviation, while improving passenger experience, boosting capacity, enhancing efficiency and minimising environmental impacts. The general objective of PRIAM is to develop a data analytics and modelling toolset that supports a passenger-centric integration of IAM into multimodal regional transport networks across Europe. The PRIAM Solution will help understand passenger needs for regional travel, anticipate IAM adoption and use patterns, plan resilient IAM infrastructure networks that are seamlessly connected with other transport modes and optimise IAM service performance taking advantage of multimodal data sharing and passenger information systems. The specific objectives of PRIAM are (i) define an impact assessment framework for regional IAM services that evaluates how different IAM vehicular concepts and business models address regional connectivity challenges and passenger needs; (ii) develop and validate a concept outline for PRIAM, consisting in a data analytics and modelling SESAR Solution for planning the integration of IAM infrastructure and services into regional multimodal transport networks; (iii) evaluate the capabilities of PRIAM through a set of case studies in European regions that show how the PRIAM Solution can help IAM regional-scale services improve passenger experience, capacity, environmental sustainability, and operational and cost efficiency; and (iv) derive a set of recommendations for the implementation of regional IAM services, based on a cost-benefit analysis that anticipates the impacts of a large-scale deployment of IAM services across Europe.

Keywords: multimodality,iam,uam,regional connectivity,human factor research,data analytics,demand modelling,vertiport location,service optimisation