Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Brain health in Atherosclerosis and Cardiovascular risk in mid-life, a PESA-Brain project (BrainAtCardio)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

This project aims to investigate the early associations between cardiovascular health and Alzheimer’s disease (AD) pathology, with a focus on subclinical atherosclerosis (SCAth) and cardiovascular risk factors (CVRFs), in a large cohort of asymptomatic, middle-aged individuals. The overarching objective is to determine how cardiovascular health in subclinical stages influences both cerebrovascular integrity and early AD biomarkers, and to examine how these factors contribute to cognitive decline, with particular emphasis on sex-specific differences. The proposed research leverages data from the PESA-Brain study, a deeply phenotyped cohort integrating advanced neuroimaging and cognitive testing, with longitudinal cardiovascular and blood-based biomarkers assessments. We will first test the relationships between cardiovascular health markers and cerebrovascular health, focusing on brain perfusion, microstructure, and microinfarcts. We will then explore the links between cardiovascular health and AD pathology, using plasma and brain amyloid and tau biomarkers, as well as cognitive outcomes, including memory and executive function. The project will employ advanced statistical approaches, such as linear mixed models and mediation analysis, to handle the complexity of multimodal data and examine causal relationships between cardiovascular health, brain pathology, and cognition. By including sex-stratified analyses, the research will provide critical insights into gender-specific susceptibilities, which have been underexplored in previous studies. The relevance of this project to the work programme lies in its potential to shift the focus of AD prevention to midlife, offering novel insights into the neurobiological pathways that link cardiovascular dysfunction and neurodegeneration. These findings could pave the way for earlier interventions targeting modifiable CVRFs, significantly reducing the incidence and societal burden of dementia in aging populations.

Keywords: cerebrovascular health,mri,pet amyloid,cardiovascular risk factors,subclinical atherosclerosis,dementia,cognition,middle aged cohort,biomarkers,cognitive decline,neurodegeneration
Unmasking the dynamic influence of the hematopoietic niche as an oncogenic path to myeloid neoplasms evolution (OncoNichPath)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1911428.0
EU funding (EUR): 1911428.0
Participants: 1
Project status: SIGNED

Although oncogenic driver mutations are found in healthy tissues sometimes at a prenatal stage, they do not often result in overt cancer. This genotype – phenotype discrepancy warrens the search for extrinsic mechanisms of cancer development and maintenance, such as aging or exposition to specific environments. Using myeloid neoplasms as a cancer model, I aim here at dissecting the hematopoietic-niche partnership at the “pre-leukemic”, “leukemic” and “post-leukemic” stage to identify innovative therapeutic strategies to prevent acute myeloid leukemia (AML) development, maintenance and recurrence. To enable experimental modelling of the bone marrow niche at different disease stages, I collected longitudinal paired stromal and hematopoietic primary patient samples, and generated physiologically-relevant in vitro and in vivo humanized models. In this proposal, I will first apply large-scale pooled genetic screening approaches to gain insights into the role of the hematopoietic-niche cellular communication processes in leukemic transformation of “pre-leukemic” clonal myeloid conditions. In the second part of the proposal, I will combine cutting-edge spatial single-cell RNA sequencing technologies with functional genetic screening to dissect the “leukemic-niche” crosstalk and ultimately fuel the development of concomitant “seeds” and “soil” therapeutic strategies. Finally, I will design a functional single-cell screening approach allowing modulation of the “post-leukemic” niche, to open the road for novel maintenance treatment strategies re-establishing healthy hematopoietic stem cells fitness advantage to prevent relapse. Overall, the proposed research project provides a framework for defining and understanding the dynamic influence of the hematopoietic niche as an oncogenic path to myeloid neoplasms evolution, and represents a key step towards therapeutic niche reprogramming from a “malignant” to a “healthy” state, to improve cancer patients’ prognosis.

Keywords: myeloid neoplasms,acute myeloid leukemia,bone marrow microenvironment,tumor stroma crosstalk,therapeutic targets,preventive and curative therapeutic strategies,prognosis biomarkers,humanized models,single cell transcriptomics,large scale genetic screens
Physiological adaptations to ecological niches in coccolithophore haplodiplontic life cycle (Cocco-Next)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Croatia
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-14
End date: 2024-11-13
Duration (months): 24.0
Total project cost (EUR): 161889.6
EU funding (EUR): 161889.6
Participants: 1
Project status: CLOSED

Human CO2 emissions are critically poisoning the earth's climate. However, sedimentation by marine primary producers contributes greatly to carbon sequestration, with coccolithophores, unicellular marine algae with cell envelopes composed of CaCO3, being the key contributors. Nevertheless, the extent of the biogeochemical impact of coccolithophores is largely unknown. They have a dual life cycle and can grow as both haploids and diploids, but past research has focused mainly on the diploid phase. Moreover, knowledge of coccolithophores is almost exclusively limited to a single species that is distributed worldwide, and can form blooms visible from space. However, this species is peculiar in many biological aspects and does not calcify in the haploid phase, therefore we need to develop more model organisms to represent impact of coccolithophores on the carbon cycle. In this action, my objective is to understand how the physiological acclimations of the coccolithophore life cycle phases allow them to inhabit different ecological niches. I will implement a multidisciplinary approach to investigate two levels of complexity: how environmental factors influence physiology and which genes contribute to distinct genetic programs. To this end, I will work on a widespread coccolithophore species that calcifies at both life cycle phases. I will characterize for the first time how photosynthesis (light-driven CO2 fixation) and photoprotection (dissipation of excess energy) differ between the two phases, and determine which environmental conditions trigger ploidy transitions. To investigate the underlying genetic factors, I will then sequence the genome and, in both phases, the transcriptome. Overall, the ambition of the Cocco-Next project is to provide important insights into the interplay between life cycles, ecological niches, and biological CO2 sequestration and beyond, create novel, interconnected and open datasets that will be invaluable to the oceanographic community.

Keywords: coccolithophores,photosynthesis,life cycle,haplodiplontic,genomics,transcriptomics,environmental conditions
Three-dimensional shock-Wave/boundary layEr intEracTions hypErsonic tuRbulent flowS (TWEETERS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands,Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-01-01
End date: 2026-12-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 2
Project status: CLOSED

Hypersonic vehicles, with velocities exceeding five times the speed of sound, are pivotal for space exploration, reusable launch technologies, and rapid civil transportation. A major challenge in advancing these technologies is the complex phenomenon of three-dimensional shock wave boundary layer interaction (SBLI). SBLI occurs when rapid shock waves from vehicle control surfaces intersect with the surrounding turbulent air layer. Understanding this phenomenon is crucial due to its impact on control, drag, heat transfer, noise, and structural integrity. This research aims to unravel the physics of SBLI in hypersonic conditions using Direct Numerical Simulations (DNS). DNS allows us to capture the real-gas effects and complex vehicle geometries, in order to explore three-dimensional effects and complex shock patterns. Successful completion of this research will provide insights into flow distortion, unsteadiness phenomena, and shock-induced gas effects, bridging the knowledge gaps and improving existing computational models for hypersonic applications. This research, therefore, carries significant implications for shaping the future of aerospace technology and exploration, given the strong implications for aerodynamics, especially in the emerging hypersonic vehicles, shedding light on unique hypersonic effects and knowledge transferability from supersonic regimes.

Keywords: high speed turbulent flows,hypersonic vehicles,shock waves,3d effects,geometric complexity,high enthalpy regime,thermochemical non equilibrium
Inflatable Concept Aeroshell for the Recovery of a re-Usable launcher Stage (a flight demonstration initiative) (ICARUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Portugal,Germany,France,Netherlands
Call: New space transportation solutions and services (HORIZON-CL4-2023-SPACE-01, 2023)
Start date: 2024-06-01
End date: 2028-02-29
Duration (months): 45.0
Total project cost (EUR): 9986088.75
EU funding (EUR): 9986088.75
Participants: 11
Project status: SIGNED

The ICARUS initiative targets to fulfil the following call’s objectives: 1) contribution to the maturation up to TRL5-6 of enabling new technologies and subsystems (including common building blocks) in the field of re-entry solutions for space transportation; 2) maturation up to subsystem and system level technology demonstration with respect to the technologies for recovery of Space Transport vehicles elements: launcher stages; In that regard, the project will address the innovative re-entry solution based on Inflatable Heat Shields (IHS), deemed applicable for recovery of Launch Vehicles stages. In order to demonstrate applicability of this innovative solution for the purpose above, the project will pursue the following endgoals: a) complete the maturation on ground of the key technologies enabling the Inflatable Heat shields: Flexible TPS and Inflatable Structure; b) carry out a mission/system design loop to realize and fly (in relevant environment) a meaningful-scale demonstrator of an Inflatable Heat Shield through a flight on board a sounding rocket where the upper part of the rocket will be recovered thanks to the IHS Demonstrator; c) execute post-flight analysis and rebuilding for technology performance evaluation, system behaviour identification, and models verification/cross-correlation; The project will lean not only on the achievements and know-how obtained in the frame of the father projects EFESTO/EFESTO-2 (respectively funded by H2020 and Horizon Europe first-batch) but also on the partners ‘heritage in the re-entry and flight demonstration field consolidated through past/recent projects. The current programmatic picture of the initiative is: • to lean on a full EU consortium • to complete the project in a ≈ 4-year plan • to carry out 1 flight campaign in EU with exploitation of EU assets (test range, sounding rockets, ground segment)

Keywords: re entry technology,inflatable heat shield,flight test and demonstration
Development of Tuxedo: a super-conducting flex-to-pcb interface connection for quantum technologies (Tuxedo)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Delft Circuits designs, manufactures, and sells disruptive innovative hardware for the quantum and cryogenic industry. Its product Cri/oFlex offers a scalable cryogenic input and output (i/o) solutions used by customers around the world. Cri/oFlex controls and reads quantum devices operating at cryogenic temperatures via a flexible substrate (flex), offering superconducting, high-density, high-performance cabling with low thermal load, minimal noise and integrated filters. The quantum industry is booming and aims to capitalize on the huge potential of quantum for all kinds of computing problems, such as AI, machine learning and complex optimization problems. The industry needs to scale from 100+ qubits now to 10k qubits in a few years, increasing the number of i/o channels. As the number of i/o channels continues to grow, the possible points of failure grow with it and costs start to explode as (coaxial) components get smaller. To scale the number of qubits per system, reliability and ease of use need to increase, while costs need to decrease. High-density, low-cost and high-performance interfacing is critical in the 10k-qubit system value chain, but it is currently missing. We can now leverage Cri/oFlex, using all current and proven aspects of Cri/oFlex to solve the interfacing bottleneck with Tuxedo. Tuxedo is an interface between Cri/oFlex and super-conducting pcbs. With Tuxedo, we can achieve the interface for a very high density of signal lines against relatively low costs in a scalable architecture. With Cri/oFlex, DC has extensive experience in developing an innovative product from research to commercially ready and beyond, and DC sees all the potential of Tuxedo to be willing to invest in developing it to become ready for marketing at scale. With support of the EIC, DC can accelerate their development roadmap for Tuxedo effectively.

Keywords: quantum,computing,electronics,signal processing,super conducting,motherboard,cryogenic
Advancing precision oncology: single cell droplet microfluidics for personalized cancer management (LIGHTHOUSE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Current cancer diagnostics rely on invasive biopsies and imaging techniques that do not provide detailed molecular information of the tumour in real time. These methods are not only painful and risky, but also limited in their ability to accurately monitor disease progression. This delay in detection significantly reduces survival rates, prevents accurate monitoring and increases healthcare costs due to the intensive treatments required at later stages. As a result, clinicians often lack the comprehensive data needed to make informed treatment decisions, putting patients at risk. Lighthouse Biotechnology aims to revolutionize cancer care with our innovative single-cell droplet microfluidics technology for performing liquid biopsies in clinical settings. Our in vitro diagnostic (IVD) device isolates and analyses circulating tumor cells (CTCs) from blood samples, providing a noninvasive, highly accurate approach to cancer monitoring and personalized treatment. This technology provides real-time molecular insights into tumor behavior, enabling precise and timely therapeutic decisions. This will be the first metabolic liquid biopsy system on the market. It measures the number of CTCs and their metabolic activity, which correlates with cancer severity and aggressiveness. This insight into disease progression enables precise treatment adjustments. Most importantly, analysis of the molecular characteristics of these cells enables personalized treatment, improving patient care and advancing precision oncology. Our technology offers significant qualitative and quantitative advantages in various segments of the value chain. We aim to finalize development and clinical validation of our device for IVD certification for clinical market, entering Research Market by 2027 and the clinical market by 2029.

Keywords: metabolic liquid biopsy,circulating tumor cells,droplet microfluidics,breast cancer,prostate cancer,personalized,cancer treatment,cancer monitoring,in vitro diagnostic device
Magnonics meets micro-electro-mechanical systems: a new paradigm for communication technology and radio-frequency signal processing (MandMEMS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Germany,France,Belgium,Italy,Hungary
Call: Advanced spintronics: Unleashing spin in the next generation ICs (RIA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-11-01
End date: 2026-10-31
Duration (months): 48.0
Total project cost (EUR): 3298408.74
EU funding (EUR): 3298408.24
Participants: 11
Project status: SIGNED

The M&MEMS project aims at combining the tunability of magnonic systems with the power efficiency and the agility of micro-electro-mechanical systems (MEMS), thus empowering a new generation of devices for radio-frequency (RF) communication and microwave signal processing. The consortium brings together 7 EU research groups and 2 industrial partners with a broad range of leading expertise in the fields of magnonics, MEMS, material science and RF electronics. We will first optimize the individual magnonic and MEMS building blocks by simulations and experiments. Then MEMS actuator with permanent magnets will be integrated in standalone PCB demonstrators for the first time. Such M&MEMS chip, which have the capacity to disrupt the wafer-scale based hardware industries, will serve as the cornerstones of a new technology platform bringing spin-wave devices to a new level in terms of energy efficiency, agility, reconfigurability and footprint. Two analog RF electronic functions have been identified by our end-users: an agile-filter with potential application in the field of 5G communication and beyond (NOKIA) and a programmable phase shifter array, the building block of novel directional antenna (Thales). A dedicated Advisory Board (including Rohde & Schwarz and ST Microelectronics) will support the two end-users, having the mission to investigate other possible applications and eventually produce the Roadmap “Beyond M&MEMS”.

Keywords: magnonics,spintronics,micro electro mechanical systems,surface acoustic wave,phase shifter,agile microwave devices
Investigating Energy-Environment-Economic Growth Linkage for Sustainability in sub-Saharan Africa (EEGLS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Lithuania
Call: ERA Fellowships (HORIZON-WIDERA-2023-TALENTS-02, 2023)
Start date: 2025-03-01
End date: 2027-02-28
Duration (months): 24.0
Total project cost (EUR): 158597.76
EU funding (EUR): 158597.76
Participants: 1
Project status: SIGNED

Energy consumption, environment, and economic growth (target variables), exist simultaneously and are inseparable. This means energy access is essential to spurring economic growth and reducing poverty; however, it adversely affects the environment. Besides, there is a negative relationship between environmental degradation and economic growth. Thus, this tension between improving energy access for economic growth and mitigating environmental externality from growth introduced a three-way link model) and their interaction impact on sustainable development is the recent research agenda. However, previous findings examined either one or two-way links (supply side, demand side, or environmental side theories) to explore the relationship between the variables. Most findings overlooked the interaction impact on sustainable development and did not measured the variables in broad or specific indicators, resulting in a gap in the literature (knowledge). Furthermore, the forward and feedback relationships between economic activities and the environment have not been examined. Therefore, this study will investigate target variables linkage and their interaction impacts on the sustainable development of sub-Saharan African countries from 2001 to 2023. The study will employ multi-country secondary panel data analysis collected from international institutions’ databases. It will analyze the descriptive statistics and basic panel data econometric tests and adopt the abovementioned theories, capital approach, and integrated sustainable development goals (iSDG) framework and employ robust methodology like the simultaneous equation model. It will provide insights into the complex relationship between target variables, inform policymakers on sustainable development strategies, and serve as a basis for further studies. The project will also encourage investment in renewable energy and conservation. The fellowship will enhance research skills, visibility, networking, and VU capacity.

Keywords: energy consumption,environmental quality,economic growth,sustainability,sub saharan africa