Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Key Account Management Services and Enhancing Innovation Management Capacity Services for Lithuanian SMEs in 2020-2021 (SME Coach LT 2020-21)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Lithuania,Lithuania,Lithuania
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 81292.5
EU funding (EUR): 81292.5
Participants: 4
Project status: SIGNED

The aim of SME Coach LT 2019 is to increase effectiveness and efficiency of investment in R&D and Innovation by enhancing innovation management capacity of the Lithuanian SME beneficiaries of the EIC Pilot schemes EIC Accelerator pilot ( SME Instrument), Fast Track to Innovation ( FTI) and Future and emerging technologies (FET-Open) under H2020 and SMEs with significant innovation activities and a high potential for internationalisation. Specifically, the project will support beneficiaries of the EIC Pilot in identifying project-specific barriers and weaknesses and gaps in their innovation capacities that hinder realization of growth opportunities and point to suitable coaches to address the identified weaknesses. The Key Account Manager will support SMEs beneficiaries in identifying critical issues and gaps with regards to their innovation idea and guide them to relevant lead coach who will support the company throughout their innovation journey. To identify SMEs challenges, the Key account Manager will use a holistic and dynamic business innovation model, supported by Business Innovation Roadmap Tool, available under Creative Commons License from smE-MPOWER network. The second specific objective aims at SMEs that have significant innovation activities and a high potential but lagging innovation management capacities. To assess the performance of their innovation management system, we will use IMP3rove Academy’s diagnostic tool or similar tools. Further action plan will be developed. In supporting SMEs we will use action- based (and case-driven) learning approach to addressing identified gaps in the innovation system. smE-MPOWER tools will help support the coaching process.

Keywords: eic pilot,eic accelerator
An Innovative Mass Spectrometry-Based Workflow for Drug Discovery (MS4Drug)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

Pulmonary Arterial Hypertension (PAH) is a life-threatening condition; even if treated, patients only have a 5-year survival rate of less than 60%. For the treatment of PAH, Chiesi Pharmaceuticals develops Rho-associated, coiled-coil-containing protein kinase (ROCK) inhibitors. The aim of this project is to elucidate conformational changes in ROCK in vitro as well as in the cellular environment that are induced by anti-PAH drug candidates, which are currently being tested in preclinical trials at Chiesi Pharmaceuticals. The ROCK interactome will be mapped to gain detailed insights into the molecular mechanisms underlying the signaling pathways of ROCK. We will decipher the effect of anti-PAH drug candidates on the ROCK interactome and elucidate drug-induced conformational changes in ROCK. Identifying novel pharmacological targets modulating specific ROCK/protein interactions will eventually lead to novel drugs for an improved treatment of PAH. This project will integrate, for the first time, in cell cross-lining mass spectrometry (XLMS), in conjunction with hydrogen/deuterium exchange mass spectrometry (HDX-MS), in the drug discovery pipeline of a pharma company. It will be the first application of the XLMS approach in the field of structural biology in Italy. The conformations and interactions of ROCK, derived by in cell XLMS, will allow a systematic validation of in vitro biochemical studies. This project aims to advance the in cell XLMS approach into a routine method for drug discovery on the system-wide level that complements HDX-MS studies using isolated proteins. Novel cross-linking reagent will be developed to bring the XLMS approach to a new level of time-resolved protein interaction studies. As such, the integrated approach described herein opens unmatched and novel perspectives for biotechnological and pharmaceutical companies. The outcome of this project is expected to have a large impact on structural biology and drug discovery in general.

Keywords: structural biology,drug discovery,pharmacology,cross linking mass spectrometry,hydrogen,deuterium exchange mass spectrometry,pulmonary arterial hypertension,structural proteomics
Unraveling the role of interoceptive abilities in aesthetic appreciation of movement (InteroceptionAction)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Australia
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 257209.92
EU funding (EUR): 257209.92
Participants: 2
Project status: SIGNED

In recent years, neuroscientific research has linked dance aesthetics appreciation to an interplay between the visual, sensorimotor, and reward systems. A specific focus has been on an observer’s familiarity with an action and its kinematic features. At the same time, there has been growing interest in investigating the relationship between individuals’ interoceptive capabilities, emotion perception, and cognitive processes, revealing strong connections between internal body signals and brain responses. Surprisingly, the potential link between interoception and movement appreciation has not been addressed yet, despite previous evidence on kinematics-related emotion recognition and given the theoretical and practical importance of establishing such a link. Specifically, if autonomic functions impact aesthetic experience, then a substantial advancement of theoretical knowledge and cognitive models of (performing) art appreciation will be possible. Knowledge translation to clinical and entertainment frameworks will also facilitate rehabilitation and audience engagement, with pragmatic and financial benefits. The project will investigate the role of interoception in movements aesthetics, in terms of time courses and neural correlates, by modulating both stimuli’ objective features (synchrony between movement speed and observers’ heart rate) and participants’ subjective experience. Neurofunctional methods will be combined with interactive training procedures to obtain precise temporal and spatial measures of brain engagement. As a whole, the action aims to bridge neuroscience and art frameworks providing a strong emphasis on individual differences and embracing open science principles. The action will provide an ideal platform for knowledge transfer between the fellow and both host institutions, and will facilitate the fellow to acquire practical skills, theoretical experience, and develop key collaborations to help him become a world-leading independent researcher.

Keywords: neuroaesthetics,interoception,cognitive processes,complex movement,action representations,interactive training,functional neuroimaging
Capacity building for aviation stakeholders, inside and outside the EU (CaBilAvi)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Coordination and support actions
Countries involved: Spain,Slovakia,Bulgaria,Poland,France,Czechia,Czechia
Call: EGNSS awareness raising, capacity building and/or promotion activities, inside or outside of the European Union (H2020-Galileo-2014-1, 2014)
Start date: 2015-01-01
End date: 2017-09-30
Duration (months): 33.0
Total project cost (EUR): 1857175.75
EU funding (EUR): 1857175.0
Participants: 13
Project status: CLOSED

The CaBilAvi consortium proposes a team of complementary skills, mixing experienced staff (GNSS Center of Excellence, Pildo Labs, Aeroclub de Sabadell, Amezen, CATC) with rightly connected partners in the EGNOS emerging countries (Univ of Prague, Univ of Zilina, VUD, F-Air, DSA) to increase the EGNOS usage rate by capacity building. Associated partners (CAA of Czech Republic, Slovakia, Bosnia-Herzegovina, ICAO) help in maximising the impact. 1. The IFR pilot training curriculum will be upgraded to include the use of LPV. Relying on the experience of the local partners in training IFR pilots, this curriculum will also be made available in English for other EU member states to enjoy. 2. Capacity building will be organised through a series of working groups to learn by doing, building onto the existing material produced by Pildo labs for similar capacity building in the FP7 project SHERPA. Bosnia-Herzegovina already committed to participate for the full pre-operational implementation track, other countries will be invited to join them. The different work shops are also open for enrolment for interested stakeholders, with ICAO expressing support to provide material and help in getting participation to the procedure design and safety case work shop. 3. VFR pilot awareness activity is led by the Czech and Slovak partners, with a very active involvement of Kosmonauta (PL) and SpecialConcepts (BU) who will use their local connection to the pilot community and the local CAA to adapt, translate and disseminate the material. 4. Dissemination and promoting of material produced in CaBilAvi, through an interactive portal, as well as a printed information packs targeted at (smaller) airports to explain what benefits EGNSS can offer them, how to get it a procedure. Close links with the Eurocontrol RAISG/ICAO PBNTF meeting and other relevant industry events, to share public deliverables and lessons learned with other ANSPs, CAAs and operators. An EGNOS yearbook will be published.

Keywords: egnos
Private garages’ access system, through a real-time and keyless solution, for cheaper and faster prime inner-city parking. (ParkBee)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Austria,Netherlands
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-10-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

ParkBee from the SME weRide (NL) is a unique intelligent parking platform that allows inner-city drivers to access under-used private garages from one click of an app. ParkBee’s innovative solution is a keyless, cloud – based generic API that can connect with stand-alone server at any parking location, thus unlocking private parking to public use without any infrastructure changes. ParkBee works as a smart plug-in easily integrated within third parties’ parking mobile apps and as a web-based interface for private garage owners to manage multiple garages in real time. After the driver reserves a space, ParkBee connects to the Access Control Point (ACP) of the garage to allow the car entrance. The further integration of the innovative (indoor) navigation technology developed by the partner SME INS Insider Navigation Systems Ltd (Austria) will allow the app to recognize when the car is in front of the garage entrance and drive it to the exact parking slot location. ParkBee will reduce cruising around searching for parking and have many positive effects within the EU and global urban and extra-urban environments: reduce air and noise pollution, greenhouse gas emissions and fuel consumption by 40%; reduce inner-city drivers journey time by 15 minutes and cut down their expenses on parking and wasted fuel by 20%. Moreover it unlocks an economic opportunity for the industry players (private parking owners) to increase their revenues. The project will contribute to the EU2020 targets, EU Sustainable Urban Mobility Plans (SUMP) and Civitas initiative. weRide software has been continuously developed since 2013 and has been successfully tested with parking app providers and access control providers. It is currently at TRL 7. Phase 1 project aims at assessing the activities needed to complement ParkBee platform (i.e. the integration of INS technology) and prepare the large scale pilot in 5 major Dutch cities and other EU countries to test market replicability.

Keywords: parking,mobility,access control system,mobile application,garages
MULTIfunctional optoelectronic devices based on hybrid heterostructures of 2D materials and photochromic SWITCHes (MULTI2DSWITCH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-08-21
End date: 2018-08-20
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

MULTI2DSWITCH will offer an extremely talented and promising young researcher, with a PhD in physics and an extraordinary track record, world-class training through research in the cross-disciplinary and supra-sectorial field of 2D materials (2DMs) based multifunctional electronics. The proposed research lies at the interface between physics, chemistry and electrical engineering, in the interdisciplinary realms of supramolecular sciences, materials- and nano-science. The overall mission is to train the fellow to become an independent scientist and to prepare him for a leading position in academia or industry. MULTI2DSWITCH’s research programme targets a fundamental breakthrough in the field 2DMs by using a combination of bottom-up and top-down methods to design ultraflat, flexible and photoswitchable heterostructures of 2D crystals and molecular self-assembled monolayers (SAMs). In order to do so, a highly-ordered SAM of photochromic molecules (azobenzenes, diarylethenes or spiropyrans) is prepared on the surface of a graphene layer, by means of low-cost solution processing techniques. The graphene/SAM bilayer is subsequently encapsulated with a 2D semiconductor from the family of transition metal dichalcogenides (TMDs) using the flake-transfer techniques commonly employed for van-der-Waals heterostructure assembly. The photo-tunable properties of the newly prepared hybrid heterostructures will be exploited to develop a series of proof-of-concept multifunctional devices, including optically-switchable diodes and field-effect transistors (FETs), and optically-programmable memory cells. Thanks to the high-degree of mechanical flexibility of both the 2D crystals and the molecular SAMs, these devices will be suitable for integration on flexible substrates. Ultimately, MULTI2DSWITCH aims at developing high-performance flexible multifunctional optoelectronic devices with figures of merit greatly surpassing those of the corresponding state-of-the-art organic devices.

Keywords: two dimensional materials,graphene,transition metal dichalcogenides,photochromic switches,self assembled monolayers,hybrid heterostructures,multifunctional optoelectronic devices
Understanding the essential function of the conserved plant-specific protein phosphatase family BSL (BSLchlamy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-12-11
End date: 2022-07-04
Duration (months): 36.0
Total project cost (EUR): 257860.8
EU funding (EUR): 257860.8
Participants: 2
Project status: CLOSED

The protein phosphatase family BSL is highly conserved and universally present in all green plants, from single-celled algae to multicellular land plants. Genetic evidence shows that it plays an essential, albeit completely unknown, role in plant cell biology. The model plant Arabidopsis has four BSL genes, but genetic redundancy coupled with embryonic lethality of mutants has seriously hampered functional studies of the family. In contrast, the green alga Chlamydomonas reinhardtii has only a single BSL homolog and the recent isolation of a temperature-conditional mutation (bsl1-1) in this gene generated a unique tool for rapid switching of BSL activity to study its molecular/celular functions. Detailed analysis of the bsl1-1 mutant identified a role for BSl1 in cell division in Chlamydomonas, specifically in mitotic progression. This phenotype is also consistent with the reduced meristem size observed in BSL knock-down in Arabidopsis and suggests an evolutionarily conserved role for the BSL phosphatase in cell cycle regulation. In the proposed project I will first perform a comprehensive proteomic/biochemical analysis of BSL1 in Chlamydomonas to identify the mechanistic basis for its key role in mitosis. This analysis with include (i) a phosphoproteomic screen to look for substrates and downstream effectors of the BSL1 phosphatase, and (ii) a characterization the BSL1 interactome using a variety of immunoprecipitation-based methods. I will then, during the return phase, translate the findings from Chlamydomonas into Arabidopsis by studying the role of BSL during root meristem development using a combination of microscopic and genetic approaches. Given the conservation of the BSL family throughout the viridiplantae, the results from this study are likely to have a broad impact on the plant biology research community.

Keywords: proteomics,phosphoproteomics,biochemistry,chlamydomonas,arabidopsis,cell cycle,cell division
Air-breathing Electric THrustER (AETHER)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling advances in space technology
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Italy,Belgium,Greece,United Kingdom
Call: SRC – In-Space electrical propulsion and station keeping (H2020-SPACE-2019, 2019)
Start date: 2019-12-01
End date: 2022-11-30
Duration (months): 36.0
Total project cost (EUR): 1999998.75
EU funding (EUR): 1999998.75
Participants: 7
Project status: SIGNED

The limiting factor for the duration of space endeavours is often related to the total mass of propellant available on board. If a new propulsion device was capable of using the upper layers of the atmosphere as propellant, this would enable a vast spectrum of new planetary mission scenarios. In recent years SITAEL has produced the world’s first example of such a device, the “RAM-EP” engine. This innovative electric propulsion (EP) thruster was successfully tested in an environment representative of VLEO, achieving TRL4. The AETHER project will advance the thruster design towards a more flight representative stage, experimentally demonstrating sufficient and reliable net thrust production for the target applications. This will be achieved through the design optimization of the various thruster components, careful selection of materials and proper diagnostics tools, together with system-level design considerations. Successful completion of the AETHER project will advance the electric propulsion portfolio of Europe with the world-first EP air-breathing engine, potentially shifting the paradigm of VLEO, LEO and planetary missions.

Keywords: air breathing,vleo,in situ resources utilisation,atmospheric propellant,trhuster technology,ram ep
IMPLEMENTATION OF A SUSTAINABLE AND COMPETITIVE SYSTEM TO SIMULTANEOUSLY PRODUCE ASTAXANTHIN AND OMEGA-3 FATTY ACIDS IN MICROALGAE FOR ACQUACULTURE AND HUMAN NUTRITION (ASTAOMEGA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-09-01
End date: 2020-02-29
Duration (months): 18.0
Total project cost (EUR): 149995.0
EU funding (EUR): 149955.0
Participants: 1
Project status: CLOSED

This project aims at developing an innovative and commercially competitive production platform for high value products as Astaxanthin and Omega-3, to be used for human nutrition or aquaculture. Astaxanthin is a pigment primary produced by microalgae: this carotenoid has a strong antioxidant power and it is used in different fields as healthcare, food/feed supplementation and as pigmenting agent in aquaculture. However, cultivation of the main microalgae species producing Astaxanthin is costly due to low biomass productivity or low Astaxanthin content, causing an extremely high price of this molecule on the market. Marine microalgae are also the primary producers of Omega-3, very long chain fatty acids, essential components of high quality diets for humans, being related to cardiovascular wellness, and proper visual and cognitive development. However, due to the high cost of microalgae cultivation, the market of Omega-3 is mostly based on fish or krill oils, with high costs and environment impacts associated. New sources of Astaxanthin and Omega-3 must thus be implemented: based on the results obtained in ERC-Stg-SOLENALGAE, an innovative, low cost and high productive strategy can be proposed for simultaneous Astaxanthin and Omega-3 production in the robust and fast growing marine microalgae species Nannochloropsis gaditana. The main objectives of the ASTAOMEGA project will be: 1. To validate to a demonstration stage the ASTAOMEGA system 2. The assessment of the market size and market requirements, through extensive market analysis 3. The identification of the best suitable commercial route to be undertaken to take the ASTAOMEGA system to the market, as inception of a spin-off company and/or the licensing agreements on the IPR exploitation with the interested end-users (see LOIs). The ASTAOMEGA team is confident that the outcomes of this project are poised to exert a beneficial impact on the European microalgae industry and nutraceuticals market

Keywords: microalgae,astaxanthin,photosynthesis,omega 3