Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Engineering a living human Mini-heart and a swimming Bio-robot (BioRobot-MiniHeart)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Germany,Spain,Netherlands,Portugal
Call: Engineered Living Materials (HORIZON-EIC-2021-PATHFINDERCHALLENGES-01, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 4475946.0
EU funding (EUR): 4475946.0
Participants: 5
Project status: SIGNED

Cardiovascular disease (CVD) is still the N1 cause of death worldwide despite the significant efforts of academia and pharmaceutical industry to understand the different underlying causes of CVD. They have been hampered by the lack of proper human cardiac models as the animal models have different physiology and gene expression from the human situation and the flat cell culture in vitro models are not capable of producing pumping motion, which is the main function of the heart. Furthermore, pesticides toxicity and risk for human health are controlled at a European level through a well-developed regulatory network, however, cardiotoxicity is not described as a separate hazard class while it can have long-term cardiovascular complications. Here we propose to make better predicative in vitro cardiac models by making a vascularized beating mini-heart and a self-propulsion swimming bio-robot made by assembling human cardiac cells into 3D tissue structures using sacrificial molding and high-resolution 3D bio-printing. The mini-heart and the bio-robot will enable the scientific community to have a more realistic human cardiac model in vitro and a proper tool to assess the presence of cardiotoxicants in the environment. This work will be done in a consortium of four parties with the necessary expertise, ranging from heart development, human pluripotent stem cells, 3D bioprinting, tissue engineering and biosensing, to bring these engineered living tissues to reality.

Keywords: human induced pluripotent stem cells,cardiac,3d bioprinting
Quantum Glass-based Photonic Integrated Circuits (QLASS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Italy,Germany,France
Call: Quantum Photonic Integrated Circuit technologies (RIA) (HORIZON-CL4-2023-DIGITAL-EMERGING-01-CNECT, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 7630014.34
EU funding (EUR): 5994221.59
Participants: 9
Project status: SIGNED

QLASS brings together experts from top research groups, up-and-coming SMEs, and industry to achieve the ambitious goal of producing a quantum photonic integrated circuit (QPIC) utilizing the extremely versatile technique of femtosecond laser writing (FLW) to fabricate 3D waveguides within glass developed for optimum photonic performance to support an unprecedented 200 reconfigurable optical modes. Compared to other QPIC techniques, glass yields extremely small interface losses (<5%) – ideal for modular, scalable architectures connecting multiple chips – with speed, affordability, and optimization for end-user goals. Incorporating high-performance single-photon sources, superconducting nanowire single-photon detectors, and electronics enabling reconfigurable state manipulation via control of an exceptionally large number of cryogenic-detector channels (200) and phase shifters (1000), we will create an end-to-end quantum photonics platform. We will implement Variational Quantum Algorithms (VQAs), leading candidates for near-term advantage, for which our platform is ideally suited. We will develop software for end users to translate their VQAs into FLW circuits, with error mitigation to enhance QPIC performance. Our principal use case is solving problems in the design of lithium-ion batteries to achieve improvements in capacity and efficiency crucial for attaining EU technological and sustainability goals. QLASS will attain substantial advancement both towards the specific QPIC objectives as well as glass development, with associated novel SNSPD processes, benefitting the wider community and enabling new quantum devices with performance far exceeding other platforms. Our combination of world-class experimentalists and theorists have the complementary expertise to successfully carry out the ambitious project objectives advancing practical QPICs.

Keywords: quantum photonic integrated circuit photonic quantum computing quantum information femtosecond laser writing superconducting nanowire single photon detectors variational quantum algorithms
Targeting Acute Leukemia with TdT-TCR-T-cell therapy (TTT-therapy)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Norway
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-10-01
End date: 2025-03-31
Duration (months): 18.0
Total project cost (EUR): 205714.29
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

The aim of this PoC project is to commercialize new therapy for acute lymphoblastic leukemia (ALL) developed in context of my ERC consolidator grant. T-cell receptors (TCRs) have in recent years emerged as promising therapeutic molecules in cell- and gene-therapy of cancer. I have completed the pre-clinical validation of a TCR that recognizes an HLA-bound peptide from a novel target, the nuclear enzyme terminal deoxynucleotidyl transferase (TdT-TCR). In vitro and in vivo data from four different mouse models show eradication of ALL and no indications of toxicity. T-cells genetically modified with the TdT-TCR effectively kill lymphoblastic cancer cells while sparing healthy B and T-cells, myeloid cells and hematopoietic stem cells. Funding has been secured for an investigator-initiated trial to determine safety and explore efficacy of TdT-TCR-T-cell therapy – TTT-therapy. The trial will recruit ALL patients relapsing from/refractory to standard therapy, who have a dismal prognosis and thus a great unmet medical need. To facilitate commercial development, I have created a start-up company and secured the company exclusive licenses for the patents on the TdT-TCR and the technology used for the development, on which I am the main inventor. In the proposed ERC PoC project, I and my strong team of advisers with expertise in the business development, clinical development, IPR and financial aspects needed for commercialization, will conduct a market analysis for TTT-therapy and develop an IPR and business strategy for the start-up company. Since several studies report expression of TdT in acute myeloid leukemia (AML), I will conduct laboratory research to determine if the TdT-TCR can also mediate killing of AML cells. AML patients have an overall 5-year survival of only 30% and hence a great medical need that potentially could be met by TTT-therapy. The described work has the potential to contribute to saving lives that would otherwise be lost to acute leukemia.
Meta Analyses of Heterogeneous Omics Data (MAHOD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-03-18
End date: 2026-03-17
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Meta Analyses of Heterogeneous Omics Data (MAHOD) will establish a framework in which data available in online repositories from previously performed Omics studies (i.e. metabolomics for analyses of small molecule metabolites in biofluids, proteomics for similar studies of proteins, etc.) will be analysed simultaneously using highly interpretable machine learning tools. These tools will reconcile differences in experimental design, demographic compositions, and modality (samples and variables that are not directly comparable). The ultimate goal of this research will be enable new insight into disease states and measure the statistical power based on the wealth of information and replicate samples available online. This will information will be exploitable by researchers in academia and industry, and will benefit the European Research Community by making better use of the data currently available for critical projects, and enable new research directions into diseases that are either poorly treatable or understood. The framework will be evaluated by an analysis of existing data on a rare disease (narcolepsy), and a much more common disease (long COVID) to ensure that the technology scales from a relatively low volume of information, to a much more challenging "big data" problem. This proposal will be carried out by an experienced researcher (ER) who completed their PhD in chemometrics, or the application of multivariate statistics and machine learning to chemical data. The ER is in a relatively unique position to bridge the gap between their knowledge of information and computer science, and domain knowledge related to the instrumentation required to perform Omics studies. The ER will be supervised by a computer scientist, who is an expert in the field of multivariate analysis and algorithm design.

Keywords: metabolomics,proteomics,transcriptomics,genomics,multivariate analysis,chemometrics
Sustainable processing of Europe's low-grade sulphidic and lateritic nickel/cobalt ores and tailings into battery-grade metals (ENICON)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Belgium,Finland,Greece,Sweden,Norway,United Kingdom
Call: Sustainable processing, refining and recycling of raw materials (Batteries Partnership) (HORIZON-CL5-2021-D2-01, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 6019237.5
EU funding (EUR): 6019237.0
Participants: 9
Project status: SIGNED

The cobalt (Co) and nickel (Ni) demand is expected to be about 20 times higher in 2040 than in 2020. Given that Europe plays only a minor role in the global Ni/Co supply chains, which are concentrated in the DRC, Indonesia and China, we face a serious problem in securing a reliable, affordable and sustainable supply of battery-grade Ni/Co, vital for Europe’s aims to be climate-neutral by 2050. In view of a “domestic and foreign sourcing” procurement model, ENICON exploits the potential of (low-grade) Ni/Co resources within Europe – i.e. sulphidic Ni/Co ores and derived Ni/Co-bearing pyrite and silicate tailings, and limonitic/saprolitic laterite Ni(/Co) ores – while improving and developing the Ni/Co-refining capacity that can process imported ores, concentrates and intermediates. ENICON comprises both major improvements to existing Ni/Co metallurgical unit operations in Europe as well as the development of a new HCl-based route for both Ni/Co sulphide concentrates and laterites. ENICON’s HCl-route dispenses with the old-school hydro-approach of continuously precipitating and redissolving metals that requires lots of chemicals and creates problematic waste streams. The HCl-based route can be extended to the downstream processing of FeNi (Class-II Ni) obtained from laterites; (2) Mixed (Ni/Co) Sulphide/Hydroxide Precipitate (MSP/MHP) from the bioleaching of Co-rich pyrite tailings; and Ni/Co-containing silicate tailings. ENICON targets a “forensic geometallurgy” protocol, making it possible to identify and mitigate the mineralogical and textural reasons for processing losses along existing and new flowsheets. To make the transition to (near) zero-waste processing and to further reduce CO2-footprints, ENICON develops enhanced mineral-matrix valorisation processes. The outputs from ENICON’s group of European Ni/Co mining, processing and refining companies will all be benchmarked in terms of positive environmental and techno-economic impacts against current methods.

Keywords: nickel,cobalt,hydrometallurgy,pyrometallurgy,geometallurgy,circular flowsheets,refining capacity
Innovative circular materials and design methods for the development of Floating Wind Turbine components for offshore Wind Farms of the future (MADE4WIND)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Norway,Denmark,Spain,Germany,Belgium
Call: Critical technologies for the offshore wind farm of the Future (HORIZON-CL5-2023-D3-01, 2023)
Start date: 2023-12-01
End date: 2027-05-31
Duration (months): 42.0
Total project cost (EUR): 6003276.25
EU funding (EUR): 6003276.25
Participants: 13
Project status: SIGNED

MADE4WIND aims to develop and test innovative components' concepts for a 15MW offshore Floating Wind Turbine (FWT) consisting of new designs and manufacturing techniques for blades, substructure, and drivetrain. The main results obtained in the project will be: - Novel FWT component design (and validation at reduced-scale): Lighter and recyclable WT blades; Improved TLP substructure (including lightweight floater concept, smaller gravity anchor and lighter tendons); and Improved drivetrain design (by a Compact generator with less rare-earths, and more reliable converter). - New material applications: new blade toughening material; new concrete; and Aluminum rebars for floating substructure. - New manufacturing processes: Preform for manufacturing blades. - Recyclability/Reuse of composites from Blades, concrete from substructure, and Aluminum rebars. - New software tools: Novel maintenance strategy and remote control systems; Improved modelling tool for LCoE analysis; Virtual model of 15MW FWT. - Guidelines: Integrated sustainability assessment; Biodiversity protection strategy; Training pathways for offshore wind local industry; Position paper with Offshore Wind stakeholders. These innovations will jointly allow future FWT to include new circular lightweight materials, minimize the impact of sea habitats, increase operational availability, reduce maintenance needs and minimize LCoE; thus, unlocking the massive deployment of >15MW floating WFs in Europe and worldwide. Partners' expertise will be key for project success, as they cover different expertise along the offshore wind value chain: Academia (SINTEF, AAU, NTNU, IFEU), consultancy (ZABALA), material suppliers (Norsk Hydro, Fibertex), WT components manufacturers (Acciona, Ingeteam, Indar) and WT manufacturer (Siemens-Gamesa). Moreover, in addition to partners' research skills, MADE4WIND proposes a strong dissemination plan, clustering with relevant Offshore Wind stakeholders, to maximise future impacts.

Keywords: floating wind turbine fwt lighter and reliable wt components new materials improved designs circularity sustainability reduced lcoe stakeholders engagement
Adaptable bio-inspired polariton-polariton energy management (ADAPTATION)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Portugal,France,Netherlands,Spain,Austria
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-04-01
End date: 2028-03-31
Duration (months): 48.0
Total project cost (EUR): 3635137.5
EU funding (EUR): 3635137.0
Participants: 9
Project status: SIGNED

Humanity is approaching a cornerstone where Climate Change will transform society, industry and economy. Therefore, moving away from inefficient energy consumption and fossil fuels is more urgent than ever. Renewable energy sources are growing fast but their full integration will make necessary not just a boost of their efficiency but rather a quantum leap in energy management. Such paradigm change will come from technologies adaptable to changing climate conditions and, importantly, making use of widely available non-critical materials. ADAPTATION vision is to challenge current paradigms in solar energy harvesting and their integration by developing a new solar material platform that will integrate thermal management and energy collection in a single material, reducing electricity peak profile and allowing easy adaptation of the energy harvesting properties to different climate conditions. For this purpose, we will take inspiration from the two most efficient energy management processes on Earth: photosynthesis and terrestrial radiative cooling. ADAPTATION will mimic simultaneously the strategies followed by plants during photosynthesis to collect and manage energy at the nanoscale and the power-free radiative cooling of Earth by thermal regulation at the microscale. These extraordinary energy collection and managing strategies are robust to disorder and provide self-regulatory cooling capacities which make them ideal to be integrated into a wide spectrum of physical objects, powering them with a sustainable energy source. In ADAPTATION we will develop the building blocks for this technology and will demonstrate its implementation with two sustainable novel device architectures. Our innovative vision is based on the multidisciplinary background of its consortium with experts in geosciences, polaritonic photonics, colloidal and supramolecular chemistry, materials engineering, quantum technologies or photovoltaics including high-tech industrial implementation.

Keywords: energy harvesting,nanophotonics,colloidal chemistry,supramolecular chemistry,geosciences,polaritonics,bioinspiration,biomimetics,photosynthesis,climate change,radiative cooling,excitonics
Exploring time-dependent memory effects in matter with viscoelastic snap-through of strips. (TiMe)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: CLOSED

Memory is crucial in living organisms and computers, but is also a hallmark of complex materials such as crumpled paper, glasses or sheared foams. Memory manifests itself in a stunning variety, and is central both in fundamental research and for applications (ageing, adaptive matter, programmable matter). A new picture based on novel theoretical concepts, related to the pathways of transitions between metastable states recently appeared, and lead to a flurry of activity. But so far, this work focused mostly on quasistatic memory effects, where the duration of the input does not matter. Yet, time-dependent memory effects are encountered in many complex systems, and their microscopic origin is often unclear. I therefore propose to study time-dependent memory and pathways in a model mechanical system, explicitly tailored to exhibit time-dependent memory, while allowing direct observations and manipulations. Specifically, I will use viscoelastic thin strips that can toggle via a snap-through instability between two states as a basic building block to create systems with emergent time-dependent memory. This project provides the key to experimentally probe and reveal the mechanisms of time-dependent memory in matter, as well as to design and create systems with complex programmable pathways. I divide my project in three work packages: WP1. First, I will study the snapping of viscoelastic strips, that will constitute the basic elements of this model system. WP2. Next, I will assemble several of these strips to monitor the emergence of time-dependent memory effects and study both their global aspects and pathways of transitions. WP3.Finally, I will aim to control time-dependent memory and design complex systems with predefined pathways. Leveraging the versatility and experimental accessibility of model mechanical In this project, I propose to use instabilities in viscoelastic strips to explore, understand and control the emergence of time dependent memory effects in matter.

Keywords: memory formation,mechanical instabilities,viscoelasticity,metamaterials
Digitizing Women of Medieval Iberian Historiography (FEMIber)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2025-08-31
Duration (months): 30.0
Total project cost (EUR): 213505.2
EU funding (EUR): 213505.2
Participants: 4
Project status: SIGNED

The interdisciplinary project “Digitizing Women of Medieval Iberian Historiography” (=FEMIber) aims to explore gender in the Iberian Middle Ages in ways that embrace emerging technologies while fostering long-lasting ties with the society and the cultural heritage in general. The project aims to study female representations in the "Crónica de Castilla" (Castile-León) and the Portuguese "Livro de Linhagens" via methods of Digital Humanities. The fellowship will take place at the Department of Humanities, the Universitat Pompeu Fabra (Barcelona) under the supervision of Prof. María Morrás. During the 24 months, a digital prosopographical database of the represented women will be generated (= objective 1), and then the subsets of data will be visualized to explore patterns, (dis)continuities and tendencies of the employed elements for sociopolitical and familial order in the two kingdoms through the lens of gender (= objective 2). When it comes to trans-sectoral training and mobility, after completing an online specialization in curatorial practices, a 6-month placement will be carried out at the company DIGIBÍS (Madrid), the Spanish heritage-digitization pioneer. During the placement, under the supervision by Xavier Agenjo, trainings in patrimony digitization will take place in order to gain new skills and explore the project’s potential in the digital Cultural Heritage field. This experience, together with the specialization in curatorial practices and the museum exposition, form part of the objective 3, dedicated to promote and advance the project´s links to the GLAM-sector, as well as facilitate public engagement and its use beyond the academia.

Keywords: digital humanities,medieval iberia,spain,portugal,historiography,database generation,digital prosopography,data visualization,female representation