Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
UNderstanding Lipid ImmunoMetabolIsm To trEat Disease (UNLIMITED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Spain,Netherlands,Italy,Ireland,France,Luxembourg,Austria,Lithuania,Denmark,United Kingdom
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-03-01
End date: 2030-02-28
Duration (months): 48.0
Total project cost (EUR): 4746960.93
EU funding (EUR): 4482132.12
Participants: 27
Project status: SIGNED

The UNLIMITED project addresses the critical challenges of lipid immunometabolism, a rapidly emerging field with transformative potential for treating immune-mediated diseases such as cancer, autoimmunity and metabolic disorders. Lipid metabolism has been recently recognized as a regulator of immune cell function, yet the intricate interactions between lipid pathways and immune responses within tissue-specific microenvironments remain poorly understood. This knowledge gap hampers the development of precision therapies tailored to the metabolic needs of immune cells in diverse tissue niches. To tackle these challenges, UNLIMITED will train 15 Doctoral Candidates in cutting-edge interdisciplinary research, equipping them with expertise spanning immunology, bioinformatics, metabolism, and drug development. A key feature of UNLIMITED training programme is the integration of leading-edge methodologies, such as multi-omics machine learning, single-cell technologies, CRISPR-Cas9, and spatial metabolomics, alongside groundbreaking techniques pioneered by consortium partners, including SCENITH, Met-Flow, click-chemistry, LIPSTIC, and advanced lipidomics. UNLIMITED’s training program emphasizes a holistic, interdisciplinary approach, providing DCs with technical skills, unparalleled expertise, and transferable competencies to thrive in academic and industrial sectors. The project will unlock unprecedented insights into how lipid metabolic pathways regulate immune cell function and adapt to changes in the tissue microenvironment. This knowledge will enable the identification of novel therapeutic targets and pioneering precision therapies for immune-related diseases. This bold initiative strengthens Europe’s leadership in health innovation, creating a new generation of highly skilled researchers ready to transform global healthcare and advance therapeutic frontiers.

Keywords: lipid immunometabolism,adaptive immunity,innate immunity and inflammation,drug development
Realizing non-abelian anyons in van der Waals materials (Anyons)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Demonstrating non-abelian exchange statistics holds the promise of leading science to new terrains where we can manipulate exotic quasiparticles. Unlike fermions, bosons, and abelian anyons, the many-body wavefunction of indistinguishable non-abelian anyons is entirely altered when swapping their positions. With the theoretical groundwork for uncovering exotic exchange properties, pioneering experiments provided preliminary evidence of the lowest-order non-abelian anyons, indicating the topological superconductivity phase. Yet, due to technological limitations inherent to current state-of-the-art platforms, new observations of non-abelian statistics or preliminary signatures of higher-order non-abelian anyons must be offered. In this proposal, I aim to directly observe the exchange statistics of non-abelian anyons, overcoming present technological challenges by incorporating proven intricate designs to innovative van der Waals (vdW) heterostructures. We will study spatial-domain and time-domain braiding of non-abelian anyons in the fractional quantum Hall effect (FQHE) regime, realized in high-mobility graphene-based heterostructures. We will perform spatial-domain QH-interferometry (Obj. 1), allowing the study of coherence and braiding of anyons; and study their exchange statistics in the time-domain via cross-correlation of current-fluctuations of partitioned anyons (Obj. 2). Higher-order non-abelian anyons will be sought after via fractional Andreev Reflection (AR) in FQHE-superconductor (SC) hybrids. Employing shot noise measurements will allow identifying the AR charge quanta (Obj. 3), while low-disorder vdW-SC interfaces necessitate an in-situ stacking and integration of pre-patterned vdW-SC layers. This research will identify phases hosting non-abelian anyons and thus lay the groundwork for their detection and manipulation. This contribution, being fundamental in its core, may also offer a practical option for fault-tolerant topological quantum computation.

Keywords: fractional quantum hall effect,abelian and non abelian states,van der waals materials,space and time braiding
Reconstructing Roman inland waterways and sea movement with advanced computational techniques (OverTheWaters)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-12-01
End date: 2026-11-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: SIGNED

The Roman conquest, occupation and dominion over a large part of current Europe and beyond marked a strong change in social, cultural and economic patterns in the area. Two of the most important and lasting changes were the establishment of a new transport network and the large-scale development of cities. Connectivity continues to be seen as an essential factor in the analysis of the spread of urbanisation, migration, the ancient economy, and the transmission of ideas. In Antiquity connectivity could only be achieved via movement by land, river and sea, and had to rely on the available transport network. While roads have been extensively investigated and they have been reconstructed in detail in provinces such as Hispania, Galia and Britannia, to date, no analysis of Roman movement and communication has incorporated navigable rivers, lakes, canals and sea transport. Orbis, the only open geospatial tool for the analysis of Roman transport, only incorporates a few major rivers and a very simple network of sea routes, which pales in comparison with the number of sea and river quays, harbours and ports archaeologically documented. Both epigraphy and classical reliefs and texts indicate Romans developed, maintained and extended the network of inland waterways. Water transport was the preferred mode of transport for goods in bulk whenever possible as it was much cheaper than road transport and constituted the basis of international commerce. OverTheWaters will reconstruct waterways and sea routes of the Western Roman Empire using big data and advanced computational methods in order to understand the importance of water movement, transport and shipbuilding technology and how it influenced the development of urban centres acting as commercial hubs and consumption and redistribution foci.

Keywords: roman,transport,waterways,network analysis,gis,computational archaeology
Engineering Gut Bacterial Phase Variation to Synergize with Immunotherapy in Melanoma Patients (SYNERGIZE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2026-03-01
End date: 2027-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Cancer immunotherapy has transformed oncology, offering new hope to patients with advanced cancers such as melanoma. However, approximately 40% of melanoma patients do not respond to current immunotherapies, highlighting the urgent need for predictive biomarkers and therapies that can increase the response and convert “non-responder” patients into “responders”. Emerging evidence indicates that the functionality of the gut microbiota plays a critical role in modulating immune responses. A common mechanism that controls bacterial functionalities is genomic DNA inversions, regulating gene expression in a phase-variable manner. This project aims to harness such gut bacterial functional plasticity to enhance immunotherapy outcomes in melanoma patients applying a dual approach: (1) developing a non-invasive quantitative PCR-based diagnostic tool to identify potential responders; and (2) engineering gut bacteria in their immune-activating phase to activate the immune system and synergize with immunotherapy. The diagnostic tool will be validated on DNA from human stool samples, assessing its sensitivity, specificity, and predictive accuracy. The genetically engineered bacteria will be tested in melanoma mouse models, evaluating their impact on tumor regression, immune activation, and survival rates. The project also includes comprehensive market, IP, and business strategy analyses to ensure successful commercialization. If successful, this innovation will provide clinicians with a reliable method for patient stratification and offer a novel therapeutic approach to enhance immunotherapy responses, improving outcomes for patients who currently have limited treatment options.
Targeting the interrelation between microglia, neurons, and astrocytes to counteract tau-mediated synaptic impairments and neurodegeneration in AD. (SynapTau)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

The overall aim of SynapTau is to evaluate the contribution of microglia on tau-mediated synaptic loss in Alzheimer’s disease (AD), based on synaptosomal changes, which may help to develop therapeutic strategies against AD. Determining the impact of tau accumulation on synaptic loss is critical since it correlates with cognitive decline in AD. Beyond tau and amyloid-β pathologies, gliosis is also an AD hallmark and is thought to play a pivotal role on synaptic loss. Despite the link between tau, synapses and inflammation in AD, we do not yet understand the specific interactions between synaptic proteins, glia and pathological tau that lead to synaptic loss. My objective is to provide a better understanding of the role of microglia in tau-mediated synaptic loss based on recent observations I made. I recently explored synaptosomes containing glial processes near synapses from microglia depleted P301S mice, a mouse model of tauopathy, to identify changes resulting from microglia depletion that account for synaptic protection against tau pathology. I reported an upregulation of UCH-L1, an enzyme required for normal synaptic function. Moreover, most of the upregulated proteins in the synaptosomes of microglia depleted-P301S mice are expressed by astrocytes. I propose to study potential protective mechanisms against tau-mediated synaptotoxicity set in motion by microglial depletion that target neurons and neuron/astrocyte interactions. In objective 1, I hypothesize that enhancing UCH-L1 expression in neurons will protect against tau-mediated synaptic damages. In objective 2, I hypothesize that neuron-glia interactions are modified after microglia depletion, with changes in the formation and function of perisynaptic astrocytic processes that may support beneficial pathological outcomes. SynapTau is a highly significant project as it aims to discover new therapeutic targets to maintain synaptic integrity and function to slow down AD neurodegeneration and cognitive decline.

Keywords: tau pathology,alzheimer s disease,synapses,microglia,astrocytes,tripartite synapses,uch l1
FOstering a Recycled European Silicon supply (FORESi)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Norway,Belgium,Latvia,Hungary,France,Italy,Slovakia
Call: Recycling technologies for critical raw materials from EoL products (IA) (HORIZON-CL4-2023-RESILIENCE-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 9034111.25
EU funding (EUR): 6999848.75
Participants: 11
Project status: SIGNED

The project FORESi aims at FOstering a Recycled European Silicon supply. through the first worldwide industrial demonstration of a cradle-to-cradle Silicon value chain. To contribute to a sustainable energy sovereignty for Europe, FORESi will demonstrate a circular recycling process from end-of-life PV panels towards new photovoltaics and EV batteries applications. The project will demonstrate the technical, economic and environmental viability of the entire recycling process, and deliver the design of an optimised recycling turnkey factory of end-of-life PV panels, paving the way for a European industrial mass production of recycled Silicon. FORESi will also develop an online integrated platform for recovery of PV panels, and deliver a PV Testing Methodology to Reuse and Repair EoL PV modules.

Keywords: silicon,pv,circular economy,ev,batteries,gigafactory
Authentication and Authorisation for Research Collaboration Technical Revision to Enhance Effectiveness (AARC TREE)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Denmark,Sweden,Germany,Italy,Finland,France,Netherlands,Switzerland,United Kingdom,Greece,Czechia,Hungary
Call: Preparation of common strategies for future development of RI technologies and services within broad RI communities (HORIZON-INFRA-2023-DEV-01, 2023)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 2491128.13
EU funding (EUR): 2372921.38
Participants: 23
Project status: SIGNED

Collaboration and sharing of resources is critical for research. Authentication and Authorisation Infrastructures (AAIs) play a key role in enabling federated interoperable access to resources. The AARC Technical Revision to Enhance Effectiveness (AARC TREE) project takes the successful and globally recognised “Authentication and Authorisation for Research Collaboration” (AARC) model and its flagship outcome, the AARC Blueprint Architecture (BPA), as the basis to drive the next phase of integration for research infrastructures: expand federated access management to integrate user-centring technologies, expand access to federated data and services (authorisation), consolidating existing capacities and avoiding fragmentation and unnecessary duplication. The main objectives of the AARC TREE project are to: (i) Capture and analyse new Authentication and Authorisation interoperability requirements (as emerging that support integration use-cases across the thematic area) and provide a landscape analysis of AAIs services (including gaps) in the RIs represented in AARC TREE (ii) Define and validate new technical and policy guidelines for the AARC BPA that address RIs use-cases. This will improve the integration of RIs across thematic areas and increase the ability of RIs to support emerging needs (iii) Expand the number of research communities that can implement the AARC BPA and/or the AARC guidelines, by providing a validation environment and toolkits. At the same time support existing AARC communities in adopting new guidelines (iv) Bring RIs, e-Infrastructures and relevant stakeholders together to align strategies to integrate new technologies, better interoperate and share resources across thematic areas and produce a compendium and recommendations for different stakeholders

Keywords: authentication,authorisation,trust,research infrastructures,e infrastructure,identity management,open science
Millimetre-Wave Superconducting Quantum Circuits (Milli-Q)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2736708.75
EU funding (EUR): 2736708.75
Participants: 1
Project status: SIGNED

I propose an experimental program to investigate quantum-coherent properties of superconducting circuits at frequencies one order of magnitude larger than those demonstrated until now. My idea is to develop a new generation of superconducting qubits with significantly increased energy level separation between their ground and the first excited states. Pushing the operation frequency of superconducting qubits up offers a number of potential technological advantages. Due to the increased level separation, such novel millimetre-wave quantum processors could be operated at much higher temperatures than their present counterparts. Even at millikelvin temperatures, the higher qubit resonance frequency will offer better protection from non-thermal noise. Furthermore, qubit logic gates can be performed faster at higher frequencies. Quantum circuit components can be reduced in size due to smaller wavelength at higher frequencies, thus allowing for a smaller footprint, denser packaging and better integration. These numerous potential advantages face nevertheless a number of challenges and pose open questions that will be addressed and are aimed to be answered in the proposed project. The goal is to develop prototype qubits for the 100 GHz frequency range and to demonstrate their manipulation and quantum state tomography. This challenging project will unearth fundamental knowledge about decoherence in this yet unexplored frequency range. We will study dielectric loss and other decoherence sources as functions of frequency and temperature. Once successful, this approach will open a new way of building a superconducting quantum computer.

Keywords: superconducting qubits,quantum computing,quantum circuits,josephson junctions,quantum engineering,superconducting electronics,mm wave electronics
Zoonoses Emergence across Degraded and Restored Forest Ecosystems (ZOE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Germany,Slovakia,Guatemala,Austria,Slovenia,Netherlands,Costa Rica,Spain,France,Mexico,United States
Call: Interlinkages between biodiversity loss and degradation of ecosystems and the emergence of zoonotic diseases (HORIZON-CL6-2023-BIODIV-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 3999483.75
EU funding (EUR): 3999483.75
Participants: 15
Project status: SIGNED

Ecosystem degradation and biodiversity loss may facilitate the emergence of zoonotic diseases. The 4-year ZOE project will analyze the links between landcover and land use changes in tropical biodiversity hot-spots facing loss of primary forest and biodiversity and in temperate regions that have undergone ecosystem degradation and deforestation over historical timescales. In areas experiencing different levels of ecosystem degradation, biodiversity assessments will be based on remote sensing-based GIS analysis of landscape structures, geobotanic plant mapping, and targeted trapping of rodents, ticks, and mosquitoes, as prototypic reservoirs and vectors of zoonotic diseases (macro-organism scale). Host- and soil-associated microbiome and virome high-throughput sequencing will be combined with assessment of human exposure to prototypic zoonotic pathogens, using high-throughput serological analyses (microbiological scale). ZOE will link with local communities and stakeholders to address perceived land use and land cover changes, disease occurrence, coping strategies, and risk behaviour. Results will be synthesized in modelling and risk mapping frameworks linking biodiversity loss and zoonotic disease risks and tested in forecasting scenarios to feed into cost-efficient monitoring schemes and early warning systems. An online knowledge platform will be created to link all relevant stakeholders of the biodiversity-health nexus, including other EU-funded consortia, national and supranational organizations stakeholders, local communities, and the public. A joint stakeholder conference will be organized, and community engagement workshops will specifically co-create and advance knowledge in local communities involved in ZOE. The ZOE project is proposed by an interdisciplinary consortium with expertise in geography, geobotanics, ecology, virology, immunology, epidemiology, sociology, psychology, anthropology and science dissemination from 7 EU and 4 American countries.

Keywords: zoonotic pathogens landcover land use changes forest ecosystem fragmentation and degradation forest restoration forest edges remote sensing habitat modelling risk mapping scenario analysis