Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
EMPOWER CONVERGED OPTICAL WIRELESS CONFIGURATIONS WITH CELL-FREE TECHNOLOGIES FOR HIGH-DENSITY 6G NETWORKS (EMPOWER-6G)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Greece,Belgium,Poland,Sweden,Denmark,Germany,Italy
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 4692219.43
EU funding (EUR): 3821918.4
Participants: 10
Project status: SIGNED

EMPOWER-6G proposes a novel converged optical-wireless architecture that realizes an efficient 6G Cell-Free (CF)-based access network for high-density and high-coverage deployments. The proposed architecture takes full advantage of the distributed processing CF concept, as well as of wireless mmWave solutions, while being in-line with the O-RAN Alliance. Specifically, the EMPOWER-6G vision is based on the development of novel solutions at the radio access domain by enabling emerging CF technologies, while also contributing innovations at the optical transport domain and significantly evolving the MEC system towards fully elastic Edge Computing. The EMPOWER-6G network configuration deploys a distributed Edge infrastructure with Data Centres (DCs) structured in 2 tiers, featuring Radio Edge Regional Edge nodes, where the former DCs hosts the Network Functions of the (virtualized) RAN fully aligned with the O-RAN specifications, while the latter DCs host non-real-time network functions. Thus, EMPOWER-6G will shape a novel 6G network configuration by addressing challenges at the radio-edge, the regional-edge, and the network-management domains. At the radio-edge domain, EMPOWER-6G aims at designing novel CF networking mechanisms that will allow the significant scaling up of Radio Unit (RU) deployment in a cost-effective manner, by exploiting the application of the distributed processing CF concept, based on the disaggregation of the traditional CF Central Processing Unit (CPU) into Distributed Units (DUs) and a Central Unit (CU), in line with the 3GPP NG-RAN architecture. In parallel, EMPOWER-6G proposes an innovative mmWave Hybrid MIMO solution, with beam-steering and beam-sharing support. At the regional-edge domain, EMPOWER-6G aims at providing a new design for an optical regional edge network with FTTH support in order to achieve optimum functional splitting options, while also supporting novel control-plane protocols for CF networking support.

Keywords: cell free networks,6g networks,network management,open ran
Engineered Heart Tissue (EHT) Devices based on Ion Conductive Guanosine-Quadruplex (GQ) Hydrogels: A Route to Advance In Vitro 3D Cardiac Tissue Models (RHYTHM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 2
Project status: SIGNED

In this project, a micro-engineered heart tissue (EHT) device that will advance the physiological relevance of current in vitro 3D cardiac tissue models will be developed. In moving towards this goal, this project will synthesize conductive guanosine-quadruplex (GQ) hydrogels and implement them as cell scaffolds in EHT devices. Key aspects of biomaterials design are the unique conductive and hierarchical 3D fibrous network and the good biocompatibility of GQ hydrogels, which will support cardiac cell culture. Upon integration in the EHT platform, the mentioned properties of GQ hydrogels will enable electrical stimulation of embedded cardiac cells under mild pacing voltages, thereby promoting the formation of morphologically and functionally mature cardiac tissue. GQ hydrogels will demonstrate high flexibility and potentially broad utility as a biocompatible and conductive biomaterial for in vitro cell experimentation. The outcomes of this project will expand the horizon of pre-clinical 3D cardiac tissue models, paving the way for future approaches to drug testing and personalized cardiovascular medicine.

Keywords: g quadruplex,conducting hydrogels,3d cardiac models,engineered heart tissue eht,rhythmic beating
Dissecting Protective and Pathogenic Long-lasting Humoral Immunity (DIPP-IMMUNE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 1995918.0
EU funding (EUR): 1995918.0
Participants: 1
Project status: SIGNED

Long term humoral immunity essentially relies on two types of cells exported from germinal centers (GC): plasma cells (PCs), which secrete antibodies, and memory B cells (MBCs). Both subsets of cells can survive for decades in humans, being responsible for the extended protection afforded by the most successful vaccines but also therapeutic failures in the context of B-cell mediated autoimmune diseases. Which cells are selected and what drives them to become long-lived, in normal or pathological conditions, remains a central question in immunology. Studies in humans have so far been curtailed by the limited amount of material available and the lack of longitudinal access to lymphoid organs. This proposal aims to address three intertwined questions for understanding the selection mechanisms underlying protective and pathogenic long-lived humoral immunity: 1. What are the cellular and molecular mechanisms driving the contraction of the MBC response in a vaccine/infectious setting? 2. Do PCs targeting a self-antigen or a vaccine/viral antigen differ in their selection, transcriptomic profile and maintenance? 3. What drives effective/defective self-reactivity purging in vaccine and pathogenic GC-dependent antibody repertoire? To tackle these questions, we have garnered unique access to key lymphoid tissues (spleen and bone marrow) involved in the initiation and long-term maintenance of the immune response from vaccinated donors and patients with a prototypic B cell-mediated autoimmune disease (immune thrombocytopenia, ITP). We believe this set of samples puts us in an ideal position, combining innovative and integrated single cell experimental approaches, to perform an in depth functional analysis of viral- and self-antigen-specific GC, MBCs and PCs and further advance our understanding of long-lived humoral immunity.

Keywords: memory b cell plasma cell germinal center vaccination autoimmunity
ValvEXA – the future of Aortic Stenosis treatment (ValvEXA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

AorticLab S.r.l., an Italian deep-tech SME, is revolutionizing the treatment of aortic valve stenosis through ValvEXA, a non-implantable, ultrasound-based device designed to restore valve functionality in both native and prosthetic aortic valves. Unlike current invasive procedures—such as surgical aortic valve replacement (SAVR) or transcatheter implantation (TAVI)—ValvEXA uses targeted ultrasonic energy to fragment and detach calcifications, preserving the valve’s structure and allowing earlier, repeatable, and lower-risk interventions. The system addresses a major global health challenge affecting over 1.7 million new patients annually, many of whom remain untreated due to high procedural risks or ineligibility for current options. By offering a minimally invasive, repeatable, and cost-effective alternative, ValvEXA expands access to care, reduces complications, and enables preventive intervention before irreversible cardiac damage occurs. Validated at TRL 6, ValvEXA has demonstrated safety and efficacy in both in vitro and in vivo models, showing restoration of leaflet motion, calcium reduction, and prevention of re-calcification without tissue damage. The company’s roadmap includes first-in-human trials and CE marking, supported by a request for €12–15 million in blended EIC funding to complete clinical validation, industrial scale-up, and regulatory approval. AorticLab, already commercializing its CE-marked FLOWer embolic protection device, leverages a strong patent portfolio, multidisciplinary expertise, and established European distribution. ValvEXA has the potential to create a new therapeutic category in interventional cardiology—shifting the paradigm from valve replacement to restoration—thereby reducing mortality, healthcare costs, and environmental impact while strengthening Europe’s leadership in MedTech innovation.

Keywords: aortic stenosis,ultrasound based therapy,non implantable device,transcatheter intervention,minimally invasive cardiology,structural heart disease,valve restoration,cardiovascular health
A disruptive anti corrosion protection software for critical offshore infrastructure through Digital Twin technology and an AI monitoring system. (PITHIA-CP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Greece
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Corrosion is one of the most worrying deterioration processes in offshore structures. The global cost of corrosion is estimated to be €2.5 trillion, which is equivalent to 3.4% of the global GDP. Offshore constructions are designed for a long-term use to cater for high-risk investments. Prediction of potential and current distribution of anodes over the architecture/design is a serious issue for the design, operation, and monitoring. Currently, simulation tools assisting engineers to design the proper CP for offshore structures are slow, inefficient, and inaccurate, have low reliability and do not provide in-real time results. Consequently, the design of an efficient cathodic protection system to prevent corrosion is crucial for a safe and profitable operation of these structures, as well as to prevent the pollution of the aqueous environment. PITHIA-CP is a world-leading Boundary Element Method (BEM) solver dedicated to simulating Cathodic Protection (CP) models, implementing innovative numerical techniques such as AI & machine learning. It accurately calculates all factors required for the design of a CP. PITHIA-CP designs the optimal CP method for each of the complex offshore structures in a reliable, user-friendly, accurate, intuitive, cost-effective and fast way, with low hardware requirements. Support from the EIC Accelerator is required to complete final technical and commercial steps, launch PITHIA-CP on the market and enable the company to move towards a point at which revenues and further fundraising can be unlocked.

Keywords: digital twins,anti corrosion,cathodic protection,simulation,maritime industry advanced computing artificial intelligence ai machine learning engineering simulation algorithms and complexity
P1: A novel therapeutic approach based on tumor-specific amplitude modulated EMF for systemic targeted treatment of cancer patients (TheraBionic)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

In EU, HCC accounts for 62,400 deaths per year & the incidence is expected to rise over the next 10-15 years due to chronic hepatitis, alcohol, obesity, limited resources, & adverse effects of expensive cancer therapies accentuating disparities in access to optimal cancer care. Hence, appropriate cancer screening programs are necessary to ensure effective treatment. TheraBionic P1 device (low-risk class IIa) includes an RF EMF generator connected via a coaxial cable to a medical-grade mouthpiece that leads to systemic delivery of low & safe EMF throughout the body activating a specific transmembrane protein that mediates anti-tumor effects on cancer cells to provide non-invasive & tumor-specific treatment for advanced HCC patients who have exhausted all curative treatment options. The early tests on more than 100 cancer patients in U.S, Europe & S.A have revealed negligible adverse events, excellent tolerability & anticancer activity in several tumor types.

Keywords: tumor specific radiofrequencies critical care medicine and emergency medicine treatment of cancer patients with impaired liver function low energy emission therapy promising approaches in treatmen
Puzzle cell nutshell waste for sustainable material solutions (PUZZLE MATERIALS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Austria
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-09-01
End date: 2025-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

In 2025 around 11 billion tonnes of plastic waste will pollute the environment. Therefore, a circular economy with biotransformation and biodegradation of oil-based plastics is as crucial as implementing biobased and biodegradable materials. Transforming lignocellulosic waste biomass into commercially valuable “green” materials is an emerging and promising way to minimize waste, substitute plastic and reduce our carbon footprint. As a waste resource, we suggest walnut shells, in which we discovered the interlocked 3-D puzzle cells. The homogeneity, the high surface area and the channels make these cells interesting for transformation into biodegradable bioplastic. We plan to dissolve the walnut shells in deep eutectic solvent to separate the cells, add water to regenerate lignin and recycle the solvent. The result of this closed process circle is a NUT slurry as a basis for our materials. To tailor and functionalize the composite for different applications we propose to add bacterial cellulose pellicles, a waste from kombucha fermentation or produced in bioreactors. The pure cellulose fibrils with high tensile strength are an exciting counterpart to the high lignin content pressure optimised puzzle cells. With different ratios of the two agri-residues we will tune the material properties for NUTplastic and NUTleather. Sustainable, energy and resource efficient, biodegradable NUTmaterials with a low carbon and environmental footprint are envisaged for the packaging and textile sector. The project activities comprise 1) development and characterisation of NUTleather and NUTplastic products at the demonstration level 2) life cycle analysis, cost of goods and carbon footprint, 3) define endusers, market analysis, potential industrial partner, buisness plan and IP strategy. We have a strong project team with highly motivated and experienced members with complimentary backgrounds and a solid wish to prove the puzzle cell performance in sustainable materials.
Ancestral molecular function of Polycomb Repressive Complex 2 (PRC2) in green algae lineage (PAMFGAL)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 150438.72
EU funding (EUR): 150438.72
Participants: 1
Project status: CLOSED

Polycomb-group (PcG) proteins assemble into complexes to maintain cellular identity in multicellular organisms and regulate phase transitions in plants by epigenetic gene repression. Polycomb Repressive Complex 2 (PRC2) is one of the complexes that is evolutionary conserved and catalyzes trimethylation of histone H3 on lysine 27 (H3K27me3). PRC2 is extensively studied in flowering plants, where it determines cell fate during development. Reports predicts putative homologs of PRC2 subunits encoded in the genomes of unicellular green algae but no molecular evidence of PRC2 complex composition, targeting and function is available. The main goal of PAMFGAL project is to describe the molecular functions of PRC2 in the green lineage to elucidate its ancestral roles. It will examine histone modifications in in three trophic states of green algae using ChIP-, RNA- and BS-Sequencing, and determine their impact on the transcription level of genomic elements. By utilizing transgenic algae and complementation of moss coupled with histone modification analysis, the project will investigate PRC2 activity conservation in the green lineage. It will characterize PRC2 complex composition using Co-IP and FRET microscopy. Phenotypic analyses of PRC2 subunit knock-out mutants will elucidate the functional role of PRC2 in growth and reproduction of green algae. Understanding of epigenetic regulation in growth and metabolism of unicellular green algae will contribute to more efficient ingredients production. Rafał Krela will be based in the group of Dr. Iva Mozgova (Biology Center CAS), focused on epigenetic regulation of photoautotrophic development and evolution of the PRCs. Training will involve algae cultivation, bioinformatical analysis, molecular biology and epigenetic methods, and the applicant will take part in leadership and project management training as well. Results will be presented at scientific and industrial conferences, and in high-profile scientific journals.

Keywords: prc2,polycomb,h3k27me3,histone modification,epigenetic,green algae,green lineage,chlamydomonas,chlorella,interactome
The Long Emergency: The Postcolonial State, Labour and the Railway Strike of 1974. (LongEmergency)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2026-01-31
Duration (months): 29.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 3
Project status: SIGNED

The Railway Strike of 1974, the last general strike on the Indian railways involved over two million workers and brought the national economy to a standstill. At once, the strike became a visible and powerful symbol of India in crisis. In June 1975, Prime Minister Indira Gandhi of the Congress Party declared the state of Emergency, marking a turning point in India's postcolonial history. Yet the two events have not been placed in one historical frame. The historical processes that congealed to produce a profound break in Indian politics — from democracy to authoritarianism remain largely unexamined. Through a 'long' history of the Emergency, with a central focus on railway labour, this MSCA project will unfold one of the multiple crises of the postcolonial state of which the Emergency was symptomatic — that of nation-building vis-a-vis the labour question. In doing so, it clarifies the place of labour in postcolonial politics, at the same time, as illuminating the character of the developmentalist state in India as a historical formation. More broadly, it includes a comparative perspective and thus illuminates the dynamics of the expansion of postcolonial states’ ambit towards labour welfarism, as well as its recourse to open authoritarianism. The project stands at the interface between – Modern South Asian History, Global Labour History, and the history of crisis and dictatorship in the Third World.

Keywords: labour history,history of modern south asia,indian history,colonial history,social history,history of postcolonial states,contemporary history
Intelligent Lung Support for Mechanically Ventilated Patients in the Intensive Care Unit (IntelliLung)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Germany,Serbia,Netherlands,Spain,Belgium,Italy,Poland,United States,Switzerland
Call: Clinical validation of artificial intelligence (AI) solutions for treatment and care (HORIZON-HLTH-2021-DISEASE-04, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 5980347.5
EU funding (EUR): 5980347.0
Participants: 21
Project status: SIGNED

Invasive mechanical ventilation (MV) is one of the most important and life-saving therapies in the intensive care unit (ICU). In most severe cases, when MV alone is insufficient, extracorporeal lung support (ELS) is initiated. However, MV is recognised as potentially harmful, because inappropriate MV settings in ICU patients are associated with organ damage, contributing to disease burden. Studies revealed that MV is often not properly provided despite clear evidence and guidelines. Furthermore, treatment decisions by the healthcare providers, especially regarding MV and ELS, often remain incomprehensible to the patients and their relatives, since flow of information from caregivers to patients is challenged by a number of factors, including limited time and resources, communication problems as well as patients? capacity to comprehend and memorise information. The project proposed herein aims at clinically validating and extending our IntelliLung Artificial Intelligence Decision Support System (AI-DSS) designed to optimise MV and ELS settings to improve the care of ICU patients, alongside caregiver-patient communication. Thereby, best practice evidence-based MV and ELS within safer therapy corridors for longer periods, faster weaning from MV, and improved survival could be achieved - even in non-experienced hands. Additionally, this project will improve the information flow from caregivers to patients and relatives in the ICU setting. Therefore, we will develop a digital solution that allows automatic generation of an extensive plain-language information package for patients and their relatives, communicating highly individualised information on diseases and knowledge-based disease-management strategies, thus facilitating high-quality current and subsequent care through health literacy empowerment and patient-centredness. We will perform a retrospective and prospective multi-centre study to validate our IntelliLung AI-DSS and the patient information software.

Keywords: extracorporeal lung support,ecmo,els,ventilator induced lung injury,vili,intelligent lung support,intelligent hybrid lung support,invasive mechanical ventilation