Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Predicting when plant-soil feedbacks promote or prevent alien plant invasion. (PSF-2-PREDICT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-27
End date: 2022-10-27
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

Predicting which alien plant species will become invasive is key to mitigating their impact. Plant-soil feedbacks (PSF) between plant species and soil microbes are crucial for controlling plant abundance. It has been suggested that positive PSF could promote alien plant invasion but that negative PSF could help their control. However, a framework to predict which alien species will experience positive feedback, and under what conditions, is lacking. My project will combine fundamental ecological theory, state-of-the-art knowledge of PSF, carefully designed experiments, and cutting-edge techniques in data analysis and high-throughput sequencing to gain a predictive understanding of the role of PSF in plant invasion. I will test the novel hypothesis that close relatedness between alien and native plant species will promote invasion when nutrients are limiting by allowing alien plants to integrate into native soil mutualistic networks, but prevent invasion under high nutrient conditions by increasing the susceptibility of alien plants to native soil pathogens. For alien and native plant species that vary in relatedness I will: 1) quantify the strength of PSF under differing nutrient conditions; 2) characterise mutualistic associations in the roots; and 3) characterise the soil microbial communities they cultivate. Moreover, I will develop an open access database of collated PSF data to facilitate further global collaborations. Results will reveal how native plant communities and their local environment influence alien plant invasions. They will lay the foundation for important applied research on the impact of plant invasions on native PSF, and how PSF knowledge might be used in ecosystem restoration worldwide. By targeting EU Regulation 1143/2014 on Invasive Alien Species and Goal 15 of the UN Sustainable Development Goals, this research will contribute to applied outcomes for the EU and substantially raise my research profile within Europe and internationally.
Supramolecular engineering of glycan-decorated peptides as synthetic vaccines (SUPRAVACC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-04-01
End date: 2025-03-31
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: SIGNED

The main and most important feature of vaccines is the induction of an immunological memory response, which is key to providing long-term protection against pathogens. The current strategies for potent antibacterial and antiviral vaccines employ conjugation of pathogen specific entities onto carrier proteins, and are limited to formulations that suffer from low stability and short shelf-lives, and are thus not viable in developing countries. Strategies for the development of new vaccinations against endogenous diseases like cancer further remain an unmet challenge, since current methodologies suffer from a lack of a modular and tailored vaccine-specific functionalisation. I therefore propose a radically new design approach in the development of fully synthetic molecular vaccines. My team will synthesise carbohydrate and glycopeptide appended epitopes that are grafted onto supramolecular building blocks. These units can be individually designed to attach disease specific antigens and immunostimulants. Due to their self-assembling properties into nanoscaled pathogen mimetic particles, they serve as a supramolecular subunit vaccine toolbox. By developing a universal supramolecular polymer platform, we will construct multipotent vaccines from glycan-decorated peptides, that combine the activity of protein conjugates with the facile handling, precise composition and increased stability of traditional small molecule pharmaceutical compounds. SUPRAVACC will pioneer the design of minimalistic and broadly applicable vaccines, and will evaluate the supramolecular engineering approach for immunisations against antibacterial diseases, as well as for applications as antitumour vaccine candidates. The fundamental insights gained will drive a paradigm shift in the design and preparation of vaccine candidates in academic and industrial research laboratories.

Keywords: supramolecular polymers,bioorganic chemistry,glycopeptide,immunotherapy
Support and Coordination of the Partnering Environment for FET Flagships (SCOPE)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Tackling grand interdisciplinary science and technology challenges
Action type: Coordination and support actions
Countries involved: Spain,Switzerland,France
Call: Partnering environment for FET flagships (H2020-FETFLAG-01-2016, 2016)
Start date: 2017-01-01
End date: 2020-03-31
Duration (months): 39.0
Total project cost (EUR): 999998.75
EU funding (EUR): 999998.75
Participants: 3
Project status: CLOSED

The SCOPE strategic objective is to promote a partnering environment with the Flagships by providing flexible and efficient mechanisms to perform activities that will be in line with the overall Flagship objectives and be of mutual benefit to all parties. In particular, the consortium will address the need for support of Partnering Projects in order to engage in collaborations with the Core Projects by identifying strategic opportunities and providing support for networking and dissemination between the Core and Partnering Projects. The enhancement and support in developing partnerships that will serve the Flagships objectives and raise awareness about the accomplishment of Flagship goals in terms of scientific leadership, economical and societal benefits. These specific actions will be carried out throughout the project lifetime with the main objective to progressively bring coherence into the Flagships “ecosystems”. The expected measureable impacts will be in term of the level of integration and participation in research, governance, networking and dissemination activities of the Partnering Projects in both of the Flagships. The SCOPE Consortium brings together different perspectives and expertise in order to achieve the goals of the project and contribute going a step forward in supporting the partnership environment in FET Flagships. They will ensure policy-level communication, coordination between and among them, networking, and other relevant actions around HBP or Graphene Core Projects and the stakeholders of the scientific community.

Keywords: graphene,human brain,fet flagships,partnering projects,partnering environment
ITCC Pediatric Preclinical POC Platform – Sofia ref.: 116064 (ITCC-P4)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Italy,Austria,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Italy,Italy,Germany,Switzerland,Switzerland,Belgium,Belgium,Sweden,France,France,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: A COMPREHENSIVE ‘PAEDIATRIC PRECLINICAL POC PLATFORM’ TO ENABLE CLINICAL MOLECULE DEVELOPMENT FOR CHILDREN WITH CANCER (H2020-JTI-IMI2-2015-07-two-stage, 2015)
Start date: 2017-01-01
End date: 2023-12-31
Duration (months): 84.0
Total project cost (EUR): 19930472.94
EU funding (EUR): 7370000.0
Participants: 34
Project status: SIGNED

Cancer remains the leading cause of disease-related death in children. For the ~25% of children who experience relapses of their malignant solid tumors, usually after very intensive first-line therapy, curative treatment options are scarce. Preclinical drug testing to identify promising treatment options that match the molecular make-up of the tumor is hampered by the facts that i) molecular genetic data on pediatric solid tumors from relapsed patients and thus our understanding of tumor evolution and therapy resistance are very limited to date and ii) for many of the high-risk entities no appropriate and molecularly well characterized patient-derived models and/or genetic mouse models are currently available. Thus, quality-assured upfront preclinical testing of novel molecularly targeted compounds in a (saturated) repertoire of well-characterized models will establish the basis to increase therapeutic successes of these drugs in children with solid malignancies. Since these tumors are overall genetically much less complex than their adult counterparts, it is anticipated that it will be easier to identify powerful predictive biomarkers to allow for accurate matching of targets and drugs. To address this high, as yet unmet clinical need, we have formed the ITCC-P4 consortium consisting of academic and commercial partners from 8 European countries and covering the full spectrum of qualifications needed for quality-assured preclinical drug development including expertise in patient derived models, histopathology, in vivo pharmacology, bioinformatics and data management, centralized testing capabilities, medical expertise regarding the entities in question, regulatory knowledge, and project management of large consortia. With this consortium in a public-private partnership with the participating pharma companies we strongly believe to be ideally positioned to greatly expedite the development of more precise and efficacious drugs for children with malignant solid tumors

Keywords: pediatric,cancer,poc platform,gemm,biomarker,relapse,organoid,solid tumor,brain tumor
KNOWLEDGE FOR PESTICIDES CONTROL (KNOWPEC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Argentina,Spain,Greece,Bolivia, Plurinational State of,Denmark,Costa Rica,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-07-01
End date: 2022-06-30
Duration (months): 72.0
Total project cost (EUR): 526500.0
EU funding (EUR): 526500.0
Participants: 7
Project status: CLOSED

KKNOWPEC, Knowledge for pesticides control, aims to create a transnational research network between Europe and Latin America focused on the challenge of unwanted pesticides in the environment. KNOWPEC wants to identify the occurrence and fate of banned and toxic pesticides in drinking and natural waters in agricultural areas of Latin America where knowledge on occurrence and risk is scarce. KNOWPEC wants to assess the environmental and potential human risks of the pesticides detected, and to provide solutions for both reducing pollution at source, and remediating contaminated water. Together, KNOWPEC will promote the sharing of knowledge at each step from pesticide analysis, toxicity and risk assessment to advanced treatment technologies that jointly enables the design of sustainable solutions to each pesticide pollution problem. Moreover, we want to create the tools of information and networking for a source of collaboration between European and Latin America institutions under the framework of the environmental and human protection from pesticides. KNOWPEC will make important contributions increasing the knowledge of pesticide pollution in potable and natural waters in selected Latin America locations providing typical (or exemplary) cases of widespread agricultural practices and ecological regions. This, together with the application of knowledge from a network of experts in chemical analysis, environmental toxicity and risk assessment, and innovative water treatment technologies in training future specialists, will contribute to safeguarding drinking water supplies and providing solutions for sustainable food production, and a sustainable environment.

Keywords: pesticide pollution,risks assessment,pesticide removal
Effective and COordinated ROAD infrastructure Safety operations (ECOROADS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Italy,Italy,Austria,Germany,Belgium,Slovakia,Norway,Serbia,Slovenia,France,Czechia
Call: Smarter design, construction and maintenance (H2020-MG-2014_SingleStage_B, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 999500.0
EU funding (EUR): 999500.0
Participants: 17
Project status: CLOSED

The general objective of the project is to overcome the barrier established by a formal interpretation of the two Directives 2008/96/EC (on road infrastructure safety management) and 2004/54/EC (on tunnels), that in practice doesn’t allow to perform infrastructure safety checks inside tunnels. The main problem is that, while from the user’s (drivers) point of view a road is a unique linear infrastructure generally in open terrain and sometimes in closed environment (tunnels), a strict application of the two Directives leads to a non-uniform approach to the infrastructure safety management outside and inside tunnels. To overcome this barrier, Ecoroad aims at the establishment of a common enhanced approach to road infrastructure and tunnel safety management by using concepts and criteria of the Directive 2008/96/CE on road infrastructure safety management and the results of related EC funded projects. Such objective will be achieved through the following specific objectives: - Workshops with the stakeholders (European tunnel and road managers); Analysis/review of national practices regarding Road Safety Inspections (RSI) and Road Safety Audit (RSA), starting from the results of the 2 studies recently launched by DG Move to assess the impact of the two Directives 2008/96/EC (on road infrastructure safety management) and 2004/54/EC (on tunnels) - Exchange of best practices and experiences between European tunnel experts and road safety professionals - Pilot joint safety operations in some European road sections having both open roads and tunnels - Recommendations and guidelines for the application of the RSA and RSI concepts within the tunnel safety operations Thanks to the high transferability of the ECOROADS results, the present formal gap (explained in details in the following paragraph) between the Directive 2008/96/EC and the Directive 2004/54/EC will be completely filled and will lead to “ faster, more sustainable and better planned interventions."

Keywords: tunnel safety management,road safety inspection,road safety audit
Can we print an aircraft at room temperature? (Print2fly)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

Within the field of aircraft manufacturing and aerospace sector, there is an increasing emphasis on thermoplastic composites and Additive Manufacturing (AM). However, current thermoplastic AM techniques are not suitable to manufacture parts with required reliability. These products suffer from poor mechanical performance stemming from the inherent weakness of printable polymers, high void content and weak bonding between printed layers. Current thermoplastic AM techniques are thermally-driven processes with serious limitations in processing of engineering thermoplastics due to high melt viscosity and process temperature of such polymers. Therefore, Print2fly is devoted to developing a new extrusion-based AM method named Reactive Liquid Deposition Modelling (RLDM) to fabricate reliable and high-performance continues fibre reinforced thermoplastic composites at room temperature. The RLDM technology employs photopolymerization of a liquid resin with tailored flow-ability and polymerization kinetics instead of the conventional melt processing. Print2fly conceptualizes a novel interphase formation between the freshly deposited layer and solidified layers and bridges the nano/micro-structure to the bonding performance and composite macro-mechanics. Print2fly will be a futuristic composite manufacturing technique to produce durable, robust, complex and recyclable parts for the aircraft industry. The chance to perform this multi-disciplinary project within a world leading thermoplastic composites laboratory will give me the opportunity to excel my competencies in polymer chemistry, mechanics of composites and advanced characterizations. This will extend my scientific knowledge in thermoplastics and AM and augment my professional maturity and independence, helping me to grow my professional network. The fellowship will open excellent career possibilities for me to reach a group leader position in the materials science and production technology fields as a future prospect.

Keywords: thermoplastics,composites,additive manufacturing,3d printing,fibre reinforced composites,bonding strength,microstructure,mechanical performance
Ecosystem function and Diversity in Amazonia (E FUNDIA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2022-01-22
Duration (months): 36.0
Total project cost (EUR): 251857.8
EU funding (EUR): 251857.8
Participants: 3
Project status: CLOSED

A key remaining challenge in ecology is understanding the relationship between biodiversity and ecosystem function at large spatial scales. Nowhere is this challenge more pressing than in the forests of western Amazonia, which not only harbour some of the most diverse forests on earth, but also hold a key role in global biogeochemical cycles. In E FUNDIA we seek to address this challenge with a unique and innovative approach, combining state-of-the-art airborne spectranomics with an exceptional floristic dataset across the most variable landscape in lowland Amazonia. E FUNDIA will bring together two of the most productive research groups in this field globally: the Asner lab at the Carnegie institution for Science and the Ecology and Global Change cluster at the University of Leeds. Working with these two groups Dr Draper (the fellow) will have the opportunity to be trained at the highest possible level, extending his knowledge and technical skills in hyperspectral remote sensing and macroecology. Whilst receiving this training Dr Draper will produce world-class science and greatly enhance his career development potential. The output of E FUNDIA will be of broad interest to the scientific community, policy makers and the general public. We are committed to disseminating the findings of the project though high impact publications, accessible policy summaries, and presenting the work at international conferences and directly to policy makers. Furthermore, we will engage with high profile media outlets to make sure as many people as possible outside the academic sphere are able to access the research. This communication will be supported by a range of outreach activities that will encourage non-specialists (both adults and children) to actively engage with the research.

Keywords: tropical forests,amazonia,tree biodiversity,imaging spectroscopy,hyperspectral remote sensing
Novel structures in scattering amplitudes (AMPLITUDES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-10-01
End date: 2023-09-30
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 1784718.75
Participants: 2
Project status: SIGNED

This project focuses on developing quantum field theory methods and applying them to the phenomenology of elementary particles. At the Large Hadron Collider (LHC) our current best theoretical understanding of particle physics is being tested against experiment by measuring e.g. properties of the recently discovered Higgs boson. With run two of the LHC, currently underway, the experimental accuracy will further increase. Theoretical predictions matching the latter are urgently needed. Obtaining these requires extremely difficult calculations of scattering amplitudes and cross sections in quantum field theory, including calculations to correctly describe large contributions due to long-distance physics in the latter. Major obstacles in such computations are the large number of Feynman diagrams that are difficult to handle, even with the help of modern computers, and the computation of Feynman loop integrals. To address these issues, we will develop innovative methods that are inspired by new structures found in supersymmetric field theories. We will extend the scope of the differential equations method for computing Feynman integrals, and apply it to scattering processes that are needed for phenomenology, but too complicated to analyze using current methods. Our results will help measure fundamental parameters of Nature, such as, for example, couplings of the Higgs boson, with unprecedented precision. Moreover, by accurately predicting backgrounds from known physics, our results will also be invaluable for searches of new particles.

Keywords: scattering amplitudes,feynman integrals