Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Selection of DNA nanostructures for multivalent binding and drug delivery (SELECTDNA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 1499812.0
EU funding (EUR): 1499812.0
Participants: 1
Project status: SIGNED

In nanomedicine, patterns, shapes and mechanics are tuned to improve performance in applications such as drug delivery and pattern matching binders. A fundamental bottleneck is that structures need to be individually assembled and tested limiting the number that can be screened and likely missing structures with optimal performance. In this proposal we describe a new class of DNA nanostructures, assembled as diverse libraries of branched DNA wireframes with complex 3D shapes that fold from single stranded genomes. The structure genomes can be amplified and sequenced allowing us to test vast pools of structures in a single pot and amplify those with the best performance transforming nanomedicine from a design to a selection problem. This proposal has three objectives: First, we will refine the tools to assemble DNA structure libraries, perform selection and analyse the sequencing data to identify structures with optimal performance. Secondly, we aim to develop DNA based multivalent antibody alternatives by selecting DNA structures that can pattern multiple aptamers with respect to the epitope distribution on targets. We will target pathogenic proteins of both bacterial and viral origin to create a new route to rapid to develop / deploy binders for diagnostics. We also aim to construct multivalent binders that are specific for nucleosomes with multiple histone modifications. The interaction between DNA nanostructures and cells are controlled by geometry, mechanics and patterns of moieties. In our third objective we will use cell-type specific uptake a selection pressure to produce patterned DNA nanostructures that can deliver gene silencing RNA with specificity to diverse cell types, including cancer cells. By moving nanomedicine from single-pot rational design to an evolutionary approach inspired by how nature produces protein and RNA structures we hope to improve current applications and unlock new applications that can’t be approached with current methods.

Keywords: dna nanotechnology,selection,avidity,drug delivery,nanopore sequencing
Demonstration of sustainable hydropower refurbishment (ReHydro)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Norway,Germany,France,Portugal,Switzerland,United Kingdom,Austria
Call: Demonstration of sustainable hydropower refurbishment (HORIZON-CL5-2023-D3-02, 2023)
Start date: 2024-05-01
End date: 2028-04-30
Duration (months): 48.0
Total project cost (EUR): 9436009.66
EU funding (EUR): 7506337.43
Participants: 24
Project status: SIGNED

Hydropower and storage capacity need to increase to meet the need for renewable and dispatchable power generation. According to IEA, worldwide hydro-power capacity should increase from 1,360 GW in 2021 to 1,563–1,782 GW by 2030 and up to over 2,500 GW in 2050. At the same time, hydropower refurbishment projects must implement modern sustainability standards that preserve biodiversity and contribute to climate change mitigation and adaptation. The main objective of ReHydro is to demonstrate how European hydropower can be refurbished and modernized to be fit for a leading role in the future power system respecting sustainability requirements and societal needs in a climate change context. A suite of monitoring and digital tools (performance, cavitation, machine health) implemented at demonstration sites will improve hydropower efficiency. Innovative concepts like retrofitting with pumped hydro and hybridization will make hydropower fit for future markets. ReHydro will demonstrate how biodiversity can be improved with new fish-friendly turbines, re-establishment of environmental flows, and monitored using new tools such as eDNA. Smarter use of water resources will also be implemented so that more services can be delivered to the power markets, while multi-purpose use of the water resources for navigation and recreation can be expanded and the ability to mitigate flooding and droughts is strengthened. The results from ReHydro will achieve all the expected outcomes specified in the call. The solutions will give European hydropower industries commercial advantages to utilise the global need for hydropower expansion. It is expected that ReHydro's exploitable results will create 700–1150 new jobs in the manufacturing industry, increasing the global market by 275 mill euros. ReHydro will introduce a new paradigm to boost European leadership and competitiveness in the hydropower industry and provide new sustainable solutions that are replicable at European and global levels.

Keywords: hydropower,refurbishment,fit for market,aquatic environment,societal services from hydropower
The Lost Manuscripts of Medieval Europe: Modelling the Transmission of Texts (LostMA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499235.0
EU funding (EUR): 1499235.0
Participants: 1
Project status: SIGNED

LostMa aims at understanding how human cultures are constituted and evolve, through the question of the transmission of written cultural artefacts. It strives to establish in what measure the transmission (and subsequent preservation or loss) of written artefacts, texts and ideas deviates from pure chance, and, if it deviates, by how much and why it does. It will do so by analysing the way that texts in manuscript form were copied, transformed or destroyed, in a similar way to the evolution of living organisms or of language variants, through process of innovation/mutation, fixation or extinction. As such, the goal of this project is not only to understand the processes behind the transmission of texts, but also to grasp the extent to which humans are the actors of the transmission of their own culture and how much the survival of texts or the constitution of cultural canons are due to chance. If this notion may seem provocative to humanities researchers, evolutionary biologists have long discovered the role of random drift in the survival or extinction of genetic traits and species. To investigate this question, this project will attempt a paradigm-shift in philological methods, by combining artificial intelligence, complexity science and philological expertise. Stochastic birth-and-death processes and computer multi-agent simulations will be used to emulate the process of textual transmission. A case study will be taken, regarding chivalric literature in European context. Supported by deep learning methods, large-scale data collection will be made on a corpus of 4000 documents in Romance, Germanic and Celtic languages, with a full-text zoom on approx. 1000 Old French manuscripts. Data will provide observable values to be compared to simulation results, in order to measure deviations from chance, make inferences on non observable values such as loss/survival rates of works and manuscripts, and understand the dynamics at work behind the transmission of texts.

Keywords: erc ver 1 00 20210323 philology history of texts digital humanities complex systems evolutionary models computational text analysis medieval european literature medieval western manuscripts stemmatology
The geometry of temporal cognitive maps CHRONOLOGY (CHRONOLOGY)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: France,United States
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-09-01
End date: 2031-08-31
Duration (months): 72.0
Total project cost (EUR): 9981292.5
EU funding (EUR): 9981292.5
Participants: 5
Project status: SIGNED

Experiencing the world and inferring its causal structure rely on the flexible temporal organization of information in the brain, enabling future planning in thoughts and actions. Understanding how the brain maps events in time is essential, yet surprisingly little is known about the neural mechanisms by which the brain represents time and uses it for computations. Based on the observation that complex neural activity accompanies the mental evaluation of time across species, our project aims at testing the hypothesis that the collective dynamics of brain circuits involved in memory generate and organize representation of temporality. To identify the key structures of time representations in the brain, we will record neural activity at different neuroanatomical scales (from neuron to whole-brain) in three species (rodents, non-human primates, and humans) while individuals are behaving in timing tasks of varying cognitive complexity. A geometrical analysis of neural activity will determine the existence of temporal cognitive maps that provide individuals with a mental chronology of experienced events. We will test if the navigation of temporal cognitive maps is involved in tasks where individuals mentally travel in time. Exploiting state-of-the-art artificial intelligence methods to build interpretable recurrent neural network models, we will identify generic processes supporting the emergence of time representations by comparing signatures of theoretical mechanisms with brain activity. Targeted causal manipulation at the single cell resolution will help select precise mechanisms among model-based hypotheses, including the role of local and long-range neuronal connectivity in the establishment of circuit dynamics that develop across time scales. Our synergistic cross-disciplinary team will establish an innovative, biologically-grounded, overarching framework for the representation of time in the brain, its dependence on context, and its relation to memory.

Keywords: time perception geometry of neural representations cognitive maps multielectrode recordings all optical electrophysiology acousto optic two photon calcium imaging recurrent neural network models computational neuroscience neural dynamics
PUlsed Laser depoSition tEchnology for soLid State battery manufacturIng supported by digitalizatiON (PULSELiON)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Sweden,Belgium,Italy,Slovenia,France,Portugal,Netherlands,Spain,Finland,Austria
Call: Manufacturing technology development for solid-state batteries (SSB, Generations 4a - 4b batteries) (Batteries Partnership) (HORIZON-CL5-2021-D2-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 6998543.0
EU funding (EUR): 6998543.0
Participants: 15
Project status: SIGNED

Europe’s objective to have 30 million electric vehicles (EVs) by 2030 can only be achieved by large scale, in-house production of highly effective and performant batteries. Development of solid-state battery technologies could improve the energy density and safety of lithium metal solid state batteries. PULSELiON project aims to develop the manufacturing process of Gen 4b solid-state batteries (SSBs) based on lithium-metal anode, sulfide solid electrolytes, and Nickel-rich NMC cathode. Novel pulsed laser deposition technique developed by PULSEDEON will be adapted and modified into a single-step vacuum process for safe and efficient manufacturing of anode components composed of lithium metal, protective layers, and sulfide based solid electrolytes. The cathode layer will be made based on conventional wet processing techniques. Initially, the anode and cathode layers will be developed in small scale for making coin cells and monolayer cells for optimising the materials and process. SSB cells will be developed with optimised process routes and will be upscaled to a pilot line proof-of-concept (TRL 6) by manufacturing large scale solid-state batteries (10 Ah). Digitalisation will be incorporated in the process modelling task with the inputs obtained from process upscaling and cell testing tasks, which will enable efficient process optimisation.

Keywords: solid state batteries ssb,digitalisation,lithium metal batteries
Hydrodynamic Performance Optimization of Trimaran Vessels for Offshore Wind Operations and Maintenance (OTOM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway,France,United Kingdom
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2027-03-31
Duration (months): 30.0
Total project cost (EUR): 283438.8
EU funding (EUR): 283438.8
Participants: 3
Project status: SIGNED

Due to rapid global development of offshore wind, challenges of ensuring high efficiency in operations and maintenance (O&M) for offshore wind turbines become prominent in reducing the levelized cost of energy. Trimaran vessels, known for their high-performance characteristics including exceptional speed, seakeeping and spacious deck areas, give advantages in performing the O&M activities effectively. Current research on the hydrodynamic performance of the trimarans primarily focuses on conventional applications without considering their practical utility related to offshore wind O&M activities. When the trimarans approaching the wind turbine substructures, unique hydrodynamic characteristics of the vessels needs to be understood to enhance the efficiency and effectiveness of the maintenance operations. To date, for offshore wind O&M applications, there is no existing detailed hydrodynamic study concerning the optimization of the outrigger layout for the trimarans. Thus, a computationally efficient hydrodynamic optimization method based on Harmonic Polynomial Cell (HPC) method will be developed in this project. The developed method will then be validated against Computational Fluid Dynamic (CFD) simulations. By utilizing Nondominated Sorting Genetic Algorithm II (NSGA-II) as a multi-objective optimization algorithm in conjunction with Back Propagation (BP) Neural Network, an outrigger layout optimization method will be tailored for the trimaran O&M vessels under different operational conditions. During the fellowship, I will employ interdisciplinary approaches for my studies, such as the applications of the HPC method in calculating multi-body hydrodynamic problems, CFD simulations in validating the developed solver and the BP neural network method in improving the multi-objective optimization efficiency. This will effectively improve my research capability and facilitate the developed optimization solver for the applications in offshore wind O&M activities.

Keywords: trimaran offshore wind operations and maintenance hydrodynamic performance multi objective optimization
SAFE AND SUSTAINABLE BY DESIGN GRAPHENE/MXENES HYBRIDS (SAFARI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Poland,Greece,Spain,Portugal,Denmark,Israel,Netherlands,Germany
Call: Sustainable safe-by-design 2D materials technology (RIA) (HORIZON-CL4-2023-DIGITAL-EMERGING-01-CNECT, 2023)
Start date: 2023-12-01
End date: 2027-05-31
Duration (months): 42.0
Total project cost (EUR): 4352740.06
EU funding (EUR): 3717547.35
Participants: 11
Project status: SIGNED

The SAFARI project aims to develop new 2D materials using sustainable and safe processes. The project focuses on creating hybrid formulations of MXenes and Graphene (Gr), which are known to possess unique and desirable properties such as thermal stability electrical conductivity. The goal of the project is to develop sustainable and safe materials that can be used in a wide range of applications such as biosensors, conductive ink, and EMI shielding. The SAFARI project begins with the preparation of precursor compounds known as MAX phases. These compounds are then used to produce two types of MXenes (Ti3C2 and Cr2C) which are further functionalized to enhance their properties and increase their affinity with Graphene. The resulting 2D hybrid materials are created using two different methods, and their structural, morphological, and functional properties are thoroughly examined. One of the main strengths of the SAFARI project is that is allinged with the SSbD principles. Thus assessment of the toxicological and eco-toxicological profiles of the new materials through a range of tests and assays will be conducted. In conclusion, the SAFARI project represents a significant step forward in the development of 2D hybrids with MXenes/Graphene for use in a wide range applications.

Keywords: safe and sustainable by design,maxphased,mxenes,2d materials,graphene
Agile, human-centric, and Real-tIme enabled open SourcE technologies advancing industrial HRI in Europe (ARISE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Spain,Finland,Poland,Italy,Germany
Call: Industrial leadership in AI, Data and Robotics – advanced human robot interaction (AI Data and Robotics Partnership) (IA) (HORIZON-CL4-2023-DIGITAL-EMERGING-01-CNECT, 2023)
Start date: 2024-01-01
End date: 2027-06-30
Duration (months): 42.0
Total project cost (EUR): 10647870.0
EU funding (EUR): 9984510.0
Participants: 11
Project status: SIGNED

ARISE will make industrial HRI deployments simpler, cheaper, and more widespread in Europe by developing and demonstrating the concept of AgileHRI. The ARISE project envisions a near future which aligns with the principles of Industry 5.0, prioritising resilient, sustainable, and human-centric work environments. In such a future, companies recognise that investing in industrial human-robot interaction (HRI) is essential for achieving better short- and long-term goals, rather than a cost. Human-centric approaches surpass traditional technology-driven approaches, with technology serving people rather than the other way around. Industrial HRI establishes its position as a game-changing asset that enables seamless collaboration between humans and robots on complex tasks, allowing them to work together in shifts of any length. On its way to materialise such a vision, the ARISE project will i) address major application challenges from today’s industry, ii) develop human-centric solutions, tools, and software modules which expand the state-of-the-art in industrial HRI, and iii) deploy industrial HRI at scale in four testing and experimentation facilities and more than 25 workplaces across Europe (FSTP Projects). The ARISE project will address these challenges using cutting-edge open-source technologies from the European innovation ecosystem and will make a significant adavance on their state-of-the-art to position Europe globally at the forefront of industrial HRI. To that aim, the project will put the focus on the achievement of four major goals: (1) to increase the efficiency and cost-effectiveness of developing, deploying, and maintaining HRI solutions; (2) To develop open-source based reusabmodules which push industrial HRI beyond the SotA; (3) to demonstrate openness and agility as crucial enablers of truly valuable and sustainable HRI solutions; (4) to ensure impact a and sustainability through a critical mass of stakeholders & strong liaisons with ADRA ecosystem.

Keywords: ros2 vulcanexus ros4hri ngsi ld long term autonomu collaboration hrc hri collaborative
Advanced epigenetics studies to increase the research and innovations capacity of the Roumen Tsanev Institute of Molecular Biology of the Bulgarian Academy of Sciences (AEGIS-IMB)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Bulgaria
Call: ERA Chairs (HORIZON-WIDERA-2022-TALENTS-01, 2022)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 2498990.0
EU funding (EUR): 2498990.0
Participants: 1
Project status: SIGNED

The global objective of the Roumen Tsanev Institute of Molecular Biology is to develop its traditionally strong focus on epigenetics and chromatin biology towards a world-class level of research excellence. Our Institute has identified Prof. Stefan Dimitrov - a top level scientist and an internationally recognised expert in the field of epigenetics -as a prospective ERA Chair holder. We intend to achieve significant improvements in research and innovations capabilities of the IMB-BAS in the area of the Institute's long term specialisation, producing a clear impact on publication quality and newly acquired knowledge with translational potential. This should be achieved by: - Transfer of knowledge with a major focus on PhD students and young postdocs to provide for sustainable growth of IMB-BAS and reduce the "brain drain"; - Raising the standards of research quality; - Improving conditions for cooperative work; - Improved capability to obtain competitive international research funding both by the ERA Chair and the rest of IMB scientists; - Translational potential: reinvigorating research will create the conditions for better innovation the findings in epigenetics directly concern mechanisms of pathogenesis; The project's implementation will also contribute in an important way to developing the national R&D sector and smart specialisation strategies. At the International level, establishing the ERA Chair holder group at IMB will help integrate the Institute with an international network of researchers in epigenetics. The project implementation is expected to have positive impact on: institutional reforms, use of existing research infrastructures, increased international research collaboration, attractiveness to excellent talents, better circulation of knowledge and expertise including between sectors, contribute to Bulgaria’s Research and Innovation Strategies.

Keywords: biochemistry and molecular biology epigenetics genetics and genomics chromatin structure and function gene regulation cell differentiation institutional reforms bulgarian epigenetics randi hub