Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Safety of GFR through innovative materials, technologies and processes (SafeG)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Nuclear safety
Action type: Research and Innovation actions
Countries involved: Germany,Hungary,Slovakia,Poland,Slovakia,France,Czechia,Czechia,United Kingdom,United Kingdom,Japan,United Kingdom
Call: Safety Research and Innovation for advanced nuclear systems (NFRP-2019-2020, 2019)
Start date: 2020-10-01
End date: 2024-09-30
Duration (months): 48.0
Total project cost (EUR): 4495010.0
EU funding (EUR): 3799914.75
Participants: 15
Project status: SIGNED

Gas-cooled fast reactor (GFR) is considered as one of the six most promising advanced nuclear reactor technologies, supported worldwide by the Generation IV International Forum and ESNII in Europe. It excels in versatility, combining very high core outlet temperatures and the possibility to close the fuel cycle, allowing for very efficient and sustainable electricity and industrial heat production. The SafeG proposal presents a Research and Innovation action aiming at connecting developers of the ALLEGRO reactor (V4G4) with European and international experts having experience in GFR and HTR research, who will utilize their unique expertise, knowledge and experience, bringing fresh ideas to the GFR development to the SafeG project will bring the GFR research and development in Europe a major step forward. It is divided into 7 Work Packages, four of them dealing with open research and development problems of GFRs, namely the core safety and proliferation resistance (WP1), advanced materials and technologies (WP2), decay heat removal (WP3), standardization and codes (WP4). Additionally, a major part of the effort (15 % of the total budget) will be dedicated to education and training activities sheltered by WP5. Dissemination and outreach activities are included in WP6 while WP7 ensures smooth management and execution of the project. The main objectives of the SafeG project are: - To strengthen safety of the GFR demonstrator ALLEGRO - To review the GFR reference options in materials and technologies - To adapt GFR safety to changing needs in electricity production worldwide with increased and decentralized portion of nuclear electricity by study of various fuel cycles and their suitability from the safety and proliferation resistance points of view - To bring in students and young professionals, boosting interest in GFR research - To deepen the collaboration with international non-EU research teams, and relevant European and international bodies

Keywords: safety,allegro,decay heat removal,advanced materials,core physics,innovative nuclear fuel,proliferation resistance,thermal hydraulics,high temperature chemistry
Unraveling the combinatorial logic of amygdala neuromodulation in decision-making and learning. (AmygdalaNeuroMod)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Proper neuronal circuit function depends fundamentally on the balance of neuromodulators, a set of neurotransmitters released widely throughout the brain. Almost every mental disorder, including anxiety and depression, that affect one out of four Europeans, are associated with a neuromodulatory imbalance in specific sub-circuits. Elucidating the role of different neuromodulatory inputs to specific brain regions holds the keys to understanding and treating mood disorders. The amygdala plays an essential role in the processing of emotional stimuli and salience, ranging from reward to threat and synaptic alterations in this region are critical for learning and emotional processing. Amygdala is innervated by every major neuromodulator, yet surprisingly little is known about the activity of these inputs under physiological conditions and how neuromodulation regulates amygdala circuit activity during different behavioral states and learning. Here, I propose to study the functional role of neuromodulatory inputs to the amygdala circuitry during learning and decision-making. Towards this goal, I will combine my experience in large-scale electrophysiology with the expertise of the host laboratory in modern genetic tools and neurotechnologies to simultaneously record and manipulate the activity of dopamine, serotonin, norepinephrine and acetylcholine inputs to the amygdala during context-guided decision-making in behaving mice. Using this approach, I aim to characterize the logic of interactions between neuromodulators and its implementation at the level of defined circuits and cell types in the amygdala and to demonstrate the role of this coordination in defining network activity, behavioral state and learning. The fellowship will contribute to our basic understanding of the interplay between two core brain systems, while it will provide me with a unique opportunity to expand my expertise and establish the foundations of my future career as an independent group leader.

Keywords: neuromodulation,amygdala,learning and memory,neuronal circuits,optogenetics,behavior,dopamine,serotonin,norepinephrine,acetylcholine,decision making,reward,context,emotion,fear
Renewable Energy for self-sustAinable island CommuniTies (REACT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Spain,Ireland,Spain,Ireland,Italy,Italy,Austria,Germany,Spain,Germany,Spain,Spain,Italy,Greece,Sweden,Serbia,France,Netherlands,United Kingdom
Call: Decarbonising energy systems of geographical Islands (H2020-LC-SC3-2018-ES-SCC, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 10715262.33
EU funding (EUR): 8974327.88
Participants: 27
Project status: SIGNED

REACT will demonstrate the potential of large-scale deployment of RES and storage assets on geographical islands to bring economic benefits, contribute to the decarbonisation of local energy systems, reduce greenhouse gas emissions (GHG) and improve air quality.To do so, REACT will deliver a scalable and adaptable cloud-based ICT platform for RES and storage enabled infrastructures, supporting a holistic cooperative energy management strategy at the community level. REACT will combine an optimal control of community owned energy assets, both conventional and renewable, with cooperative demand response (DR) actions, both explicit and implicit, to maximally exploit the flexibility of energy demand. To achieve this, REACT will leverage on energy production and consumption modelling, grid operation fault detection and diagnostics, multi-carrier supply optimization and optimal energy dispatching, while enabling synergies between different energy networks and micro-grids of island. REACT will deliver effective business models making a synergy of grid- and community-centric approaches for sustainable RES solutions, increased renewable energy exploitation, integrated and digitalised smart grids, and DR programs. Moreover, REACT will provide a solution that is fully compliant with contemporary regulatory and legal aspects, while respecting the data security and applying suitable data protection measures. REACT will target to enhance the overall energy security of geographical island with an inherent possibility for scale-up and deliver at least 10% energy savings, energy costs savings and GHG emission reduction both by 60%, and at least 50% increase in RES generation and similar reduction in fossil fuel consumption. REACT solution will be validated in 3 demo islands, while replication plans will be made for 5 other “follower” islands across EU.

Keywords: res and storage integration,energy infrastructure planning,optimal energy dispatch,demand response
Controlling evolutionary dynamics of networked autonomous agents (CORNEA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-05-01
End date: 2023-04-30
Duration (months): 60.0
Total project cost (EUR): 1998933.0
EU funding (EUR): 1998933.0
Participants: 1
Project status: SIGNED

Large-scale technological, biological, economic, and social complex systems act as complex networks of interacting autonomous agents. Large numbers of interacting agents making self-interested decisions can result in highly complex, sometimes surprising, and often suboptimal, collective behaviors. Empowered by recent breakthroughs in data-driven cognitive learning technologies, networked agents collectively give rise to evolutionary dynamics that cannot be easily modeled, analysed and/or controlled using current systems and control theory. Consequently, there is an urgent need to develop new theoretical foundations to tackle the emerging challenging control problems associated with evolutionary dynamics for networked autonomous agents. The aim of this project is to develop a rigorous theory for the control of evolutionary dynamics so that interacting autonomous agents can be guided to solve group tasks through the pursuit of individual goals in an evolutionary dynamical process. The theory will then be tested, validated and improved against experimental results using robotic fish. To achieve the aim, I will: (1) develop a general formulation for stochastic evolutionary dynamics with control inputs, enabling the study on controllability and stabilizability for evolutionary processes; (2) introduce stochastic control Lyapunov functions to design control laws; (3) construct new classes of conditional strategies that may propagate controlled actions effectively from focal agents in multiple time scales; and (4) validate experimentally on tasks with unknown difficulties that require a group of robotic fish to evolve and adapt. The project will result in a major advance from the conventional usage of evolutionary game theory with the systematic design to actively control evolutionary outcomes. The combination of theory with experimentation and the multi-disciplinary nature of the approach will lead to new applications of autonomous robotic systems.
Neural and behavioral underpinnings of contextual modulations in Autism (NBUCA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

Social cognition impairments, including deficits in nonverbal communicative behaviors used in daily life interactions are considered to be among the core deficits associated with Autism Spectrum Disorders (ASDs). So far, these deficits have been traditionally studied by using non-realistic stimuli embedded in abstract tasks. These tasks are not good models of the world because they lack the context of everyday-life situations. Although contextual processing during action comprehension has been extensively studied in other disorders (e.g. schizophrenia), much less is known about the role that it plays in ASD. Strikingly, those few studies that have used more ecological paradigms in which contextual information was given have shown that ASD individuals are able to improve their ability in reading out other’s actions. Therefore, a broader explanation of ASD which considers the influence that context, as an intrinsic part of social cognition, has on this disorder is timely and clearly required. The general aim of NBUCA is to study the neural and behavioral underpinnings of contextual modulations in ASD during action comprehension and answer many challenging questions: a) Do children and young adults with ASD have a general deficit in integrating context and behavior? If this is true, b) Does this deficit relies more on the processing of social or non-social contextual cues (or both)? Given this, an ecological context-dependent social cognition paradigm will be designed and further implemented in a set of experiments combining behavioral and psychological measures with transcranial magnetic stimulation (TMS). Overall, we expect that by enhancing contextual information ASD individuals will improve their ability in comprehending others’ actions. Together, our findings will provide novel insights on the impact that context has on ASD. This will be of clinical relevance for developing a more ecological framework that includes contextual sensitivity evaluation and treatment.

Keywords: autism spectrum disorders,social impairments,context,action comprehension,ecological,paradigm,transcranial magnetic stimulation,transient virtual lesions,corticospinal excitability
A Hot-Spot Bio-Barcode Strategy for Prognostic Biomarkers In Colorectal Cancer (BioBarPro)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Switzerland
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2015-12-01
End date: 2017-05-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Colorectal cancer (CRC) is caused by alterations in genes that regulate tissue growth and the risk of developing CRC is influenced by a combination of environmental and genetic factors. Although CRC is often preventable by removing precursor lesions, screening efforts have been hampered by low participation rates and by performance limitations of the screening tools themselves. Detection of blood in faeces is currently the most common screening tool, while stool DNA testing of molecular markers has emerged as a biologically rational and user-friendly strategy for the non-invasive detection of CRC and critical precursor lesions. This advance has significantly increased performance in detecting CRC, but still more than half of the precancerous lesions cannot be detected. The stool DNA test performance for detecting precancerous lesions is expected to be improved substantively by including a completely new type of biomarker, those formed earlier than genetic mutations in the process of carcinogenesis. Such biomarkers are DNA adducts; DNA molecules bound to chemicals. If not repaired, these DNA adducts generate mutations. Herein, we propose to expand an ERC-funded research result into a kit for measuring CRC-initiating DNA adducts in a stool sample. This kit will enable personalized feedback that quantitatively integrates environmental and genetic factors in colon-cancer associated DNA damage. We have filed a patent application for the chemical basis of the technology and have partnered with an ETH spin-off for the scientific development of our existing proof of principle assay to a prototype kit. In parallel to the scientific work, during the Proof of Concept phase, we will address a phase of the overall commercialization plan that involves licensing the technology to a business partner in the life sciences sector.

Keywords: dna adducts,diagnostic kit,hybridization probe,colorectal cancer,disease prevention,stool dna testing
Physiologically relevant microfluidic neuro-engineering (CONNEXIO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2016-11-01
End date: 2021-10-31
Duration (months): 60.0
Total project cost (EUR): 1727731.0
EU funding (EUR): 1727731.0
Participants: 1
Project status: TERMINATED

Developing minimalistic biological neural networks and observing their functional activity is crucial to decipher the information processing in the brain. This project aims to address two major challenges: to design and fabricate in vitro biological neural networks that are organized in physiological relevant ways and to provide a label-free monitoring platform capable of observing neural activity both at the neuron resolution and at large fields of view. To do so, the project will develop a unique microfluidic compartmentalized chips where populations of primary neurons will be seeded in deposition chambers with physiological relevant number and densities. Chambers will be connected by microgrooves in which neurites only can grow and whose dimensions will be tuned according to the connectivity pattern to reproduce. To observe the activity of such complex neural networks, we will develop a disruptive observation technique that will transduce the electrical activity of spiking neurons into optical differences observed on a lens-free platform, without calcium labelling and constantly in-incubo. By combining neuro-engineering patterning and the lens-free platform, we will compare individual spiking to global oscillators in basic neural networks under localized external stimulations. Such results will provide experimental insight into computational neuroscience current approaches. Finally, we will design an in vitro network that will reproduce a neural loop implied in major neurodegenerative diseases with physiological relevant neural types, densities and connectivities. This circuitry will be manipulated in order to model Huntington and Parkinson diseases on the chip and assess the impact of known drugs on the functional activity of the entire network. This project will engineer microfluidics chips with physiological relevant neural network and a lensfree activity monitoring platform to answer fundamental and clinically relevant issues in neuroscience.

Keywords: microfluidics,neuro engineering,neural networks
Geometric and analytic aspects of isoparametric hypersurfaces (ISOPARAMETRIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-16
End date: 2019-08-20
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Isoparametric hypersurfaces are intriguing geometric objects whose study has revealed connections with several areas of mathematics and mathematical physics, and which have typically been investigated with differential geometric, algebraic or topological techniques. The aim of this proposal is to develop an innovative approach to isoparametric hypersurfaces by combining already established tools with methods from geometric analysis and partial differential equations. Specifically, we intend to investigate the existence of isoparametric hypersurfaces in general Riemannian manifolds, the role of these objects in overdetermined problems of elliptic partial differential equations, and the isoparametricity of compact hypersurfaces with constant mean curvature in noncompact symmetric spaces. In order to develop this proposal, the Experienced Researcher will join the Geometric Analysis team at ICMAT, in Madrid, under the supervision of one of its main researchers, Alberto Enciso. The host group has extensive experience in the study of the geometric properties of solutions to differential equations, and their main researchers have recently developed powerful methods to address outstanding problems in fluid mechanics and geometric analysis. The scientific training strategy of this proposal consists in the assimilation of these techniques. On the other hand, the Researcher is experienced in the classical theory of isoparametric hypersurfaces, as evidenced by his contributions to the field. It is the combination of both backgrounds what is needed to develop this proposal. Finally, this MSC fellowship would boost the convergence of distinct research fields and collaborative networks, produce a synergy with the ERC Starting Grant hold by the Supervisor, diversify the fellow’s mathematical knowledge, and consolidate him as an independent researcher.

Keywords: isoparametric hypersurfaces,constant mean curvature,overdetermined boundary value problems,riemannian submanifolds,symmetric spaces