Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Robot Immune System (RIS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-07-01
End date: 2019-11-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The new era of robotics is invading our factories, homes, hospitals and productive companies. Although the consumer sector is gaining importance with the introduction of domestic robots such as drones or home appliances, the industrial sector is the largest robotics market and has the highest market share. Industrial robots are helping the migration of the industry to automatization of difficult and repetitive tasks and connected robots are improving productive ratios in a more globalized world. However, the remarckable growth has brought other problems related to security as no solutions are caring about robot vulnerabilities. Cybercrime in robotics could cause a company lose hundreds of thousands of euros, industrial expionage or even worst, can affect into robots operation. Robots cyberattacks may cause physical damage to near operators, compromising safety. Robot manufacturers or traditional cybersecurity companies are neglecting cybersecurity leaving security issues up to end users, which are the most vulnerable in the value chain of robotics. ALIAS ROBOTICS is a young firm, founded by a group of experienced entrepreuners with the firm idea that robot cybersecurity is a must. Following this commitment, ALIAS developed the Robot Immune System (RIS), a bioinspired hardware solution which mimics the defensive principle of the human immune system to protect and prevent attackers exploit vulnerabilities in robots. RIS system is oriented to robot end-users and integrates a Artificial Immune framework which empowers Artificial Intelligence to create the next generation robot security. RIS cognitive model has a filed European patent (EP18382834) in all EU countries which will guarantee its protection and its commercial activity in the targeted markets, ensuring its commercialization. ALIAS ROBOTICS' impact is expected to grow 30 M€ in turnover and creating around 180 direct jobs and more than 200 indirect jobs in supplying companies.

Keywords: robotics,cybersecurity,cyberattacks,industry 4 0,iiot,immune
Recursive Engineering electronic Properties of Artificial energy Materials with multi-Pulse Spectroscopy (REPAMPS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

Organic Photovoltaic (OPV) cells are one of the most promising energy conversion materials of our modern world due to their high-mechanical flexibility, robustness, and low-cost production. However, a crucial drawback remains: their low energy conversion efficiency. A reason for this can be ascribed to electronic-vibrational dynamics affecting the ultrafast charge separation occurring in the material upon light absorption. Substantial efforts have been made to defeat this problem, however the incomplete understanding of the elementary mechanism governing the conversion process has restrained further advancements in this direction. In REPAMPS (Recursive Engineering electronic Properties of Artificial energy Materials with multi-Pulse Spectroscopy). I will deliver a first-principles theoretical description of the charge transfer mechanism governing the energy conversion for a prototypical OPV, the P3HT-PCBM blend, and introduce the novel Spectrally Engineered Control (SEC) methodology to direct the charge transfer process towards higher power conversion. A TDDFT methodology will be used to parametrize the P3HT-PCBM heterojunction in its environment, and a molecular dynamics protocol will be adopted for a realistic modelling of the dissipation and spectral bath. Quantum dynamics with explicit description of the external fields and calculation of various time-resolved optical spectroscopies will be simulated. The signals will be validated in collaboration with an experimental group. Nonadiabatic dynamical processes (e.g. conical intersections) affecting the charge transfer and the environment role will be carefully investigated. Last, I introduce the SEC approach combining optimal control theory with the analysis of the spectra, representing a solid strategy for the photocontrol of the molecular mechanism (charge-transfer) governing the power conversion in OPV materials. I will then propose new design strategies for OPV materials using the insights gained from REPAMPS.

Keywords: artificial energy materials opvs,time resolved multidimensional spectroscopy,ultrafast,nonadiabatic dynamics,tddft,molecular dynamics simulations,optimal control theory
Prostate cancer urinary diagnostic kit based on RNA biomarkers (PROSKit)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2020-01-01
End date: 2020-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Arcis Biotechnology Holdings developed and patented PROSKit, a molecular diagnostic platform for the diagnosis of prostate cancer based on urine analysis, able to reduce the number of false positive from the PSA test and so the number of unnecessary biopsies. PROSKit is a proprietary mix of chemicals, that can stabilise nucleic acids (RNA/DNA) in urine for up to 2 weeks at room temperature and then allow sampling at home or Point of Care (PoC) using a patient-friendly sample collection technology, preserving unstable RNA biomarkers and analysis in specialized clinical environment through the PCA3 biomarker. With respect to current diagnostic methods (PSA + biopsy), PROSKit offers i) Rapid- samples ready for analysis in <3 minutes, results in <2 hours if tested at surgery, compared to days for biopsy, ii) Accurate- greater sensitivity and specificity than current PSA blood test: PCA3 presents a 28% higher discriminative capability than PSA; iii) Inexpensive- as informative as multi-core biopsy for <10% of the price; iv) High throughput- PROSKit samples can be collected anywhere, non-invasively and thousands analysed simultaneously at a central location. Compared to competitors proposing RNA stabilization requiring laboratory analyses, complex procedures and specific tools, PROSKit offers stabilization at room temperature and with no lab equipment in 3 minutes. Intact amplifiable RNA biomarkers have already been validated for 7 days stability but needs to extend validation for >14 days, validate the protocol for patients to collect urine and analysts to perform assay; certify design of PROSKit device and cost for the device and define agreement with partners for distribution and license for execution of tests. DNA/RNA Sample preparation business market revenues are expected to reach 1.85 billion € in 2025. Kits segment represents 60% of the market: 1.11 billion € in 2025.

Keywords: rna stabilisation,urine analysis,prostate cancer,rna biomarkers,diagnostic kit
Understanding the role of CyclinB1-NuMA interaction in spindle orientation and epithelial morphogenesis (NuMA_CyclinB1_EM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: SIGNED

In multicellular organisms, oriented cell divisions sustain tissue morphogenesis, tissue architecture and homeostasis by ensuring the correct positioning of daughter cell after mitosis. Accurate execution of oriented divisions and chromosome segregation relies on the positioning of an essential actor, the mitotic spindle. The consequence of spindle misorientation is drastic. Disruption of any of the spindle orientation factors could lead to genetic instability, tissue disorganization and tumorigenesis. However, cell division is controlled not only in orientation, but also in time. Indeed, spindle orientation is also very important for a wide range of developmental processes, ranging from germline stem cell division to epithelial tissue homeostasis and regeneration. A more complete understanding of how spindles are oriented will therefore require more extensive research, e.g. using CRISPR-based strategies to interrogate the proposed interactions in vivo, into how the spindle-orienting machinery is localized and regulated in multiple systems. The aim of this project is to advance knowledge on how cell cycle regulates spindle positioning and its contribution in epithelial morphogenesis in the intestinal tissues. This advance knowledge will serve to better understand the pathogenic mechanisms of important human diseases such as cancer.

Keywords: numa,cyclinb1,spindle orientation,epithelial morphogenesis
Fundamental and Applied Science using Two Dimensional Angstrom-scale capillaries (AngstroCAP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-09-30
Duration (months): 68.0
Total project cost (EUR): 1619466.0
EU funding (EUR): 1619466.0
Participants: 1
Project status: SIGNED

I will construct and apply next generation capillary devices as an exciting experimental platform to enable ground-breaking investigation of structure and dynamics of water at the ultimate molecular scale. These devices are in a lab-on-a-chip type configuration with angstrom-scale channels and atomically smooth walls. I am making them by scrupulous assembly tools in a controllable and reproducible fashion and they are extremely stable. Myself and my team will assemble capillaries of a few microns in length, by sandwiching two blocks of layered crystals, e.g., mica, graphite, boron nitride, separated by an atomically thin 2D-crystal spacer. Inside these channels, we will image water condensation along with simultaneous structure analysis by spectroscopy, under in-situ (temperature, pressure) environments. Another key aim of the project is to produce 2D slit-like pores on a large scale by slicing the pre-made 2D capillaries using sharp diamond knives, and explore their applications in size selective separation and biomolecular translocation. This ambitious research program is only possible because of my extensive angstrom-scale fabrication expertise, coupled with world leading fabrication capabilities at the University of Manchester. Objectives 1: To utilize angstrom-scale capillaries constructed out of two-dimensional (2D) materials as a versatile platform for studying confinement effect on structure and dynamics of water. 2: To construct new types of angstrom-scale 2D-pores from these capillaries for studying size-selective molecular separation, biomolecular sequencing and translocation. The project will have a lasting impact in understanding what the angstrom-scale confinement offers in terms of active control of molecular transport. Such confinement effects are efficiently utilized in various natural systems (e.g., protein channels) and the results could even aid in designing elementary building blocks of stimuli responsive artificial fluidic circuitry

Keywords: angstrom,2d materials,angstrofluidics,water,nanopores,sequencing,molecular separation
Structural and biochemical studies on the regulation of transcription during elongation (TRANSREG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: France
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-06-01
End date: 2021-05-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

During the first step of gene expression, a universally conserved enzyme called RNA Polymerase (RNAP) transcribes RNA from a DNA template in every cell. Transcription is a fundamental, yet incompletely understood process. Because of its central role, the bacterial transcription machinery is also a prime drug target. Crystal structures of RNAP core as well as RNAP elongation complexes (ECs) have revolutionized our understanding of transcription. This groundwork paved the way to address more complex questions regarding the regulation of transcription. Transcriptional regulation impacts every aspect of biology including a growing list of human diseases. Transcriptional pausing, a temporary interruption of transcription during elongation, plays a major role in regulating gene expression in pro- and eukaryotes. A full and mechanistic understanding is crucial and requires a combination of structural and biochemical studies. This is where the proposed work will contribute. Our goal is to understand how transcription factors modulate RNAP during the elongation phase. Biochemical and structural approaches (X-ray crystallography and single particle cryo-EM) will be used to gain detailed insights on the regulation of transcription by protein factors and non-coding RNAs (ncRNAs). To complement the results, an experimental system will be established using Fluorescence Resonance Energy Transfer (FRET) to study the dynamics of RNAP. This system will allow us to address questions concerning RNAP dynamics during processes that regulate transcription. Specifically, we propose 3 aims: 1.: Investigate the role of transcription elongation factors that modulate RNAP pause behavior and couple transcription and translation 2.: Study the role of RNAs that regulate transcription 3.: Establish an experimental system to study RNAP dynamics using FRET The proposed work will lay the groundwork and prepare the team to address similar questions in higher organisms in the future.

Keywords: transcription,rna polymerase,regulation of transcription,transcriptional pausing
HYDRALAB+ Adapting to climate change (HYDRALAB-PLUS)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Spain,Italy,Spain,Germany,Norway,Finland,Poland,Romania,France,France,France,France,Netherlands,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom,Portugal,United Kingdom,United Kingdom,Portugal
Call: Integrating and opening existing national and regional research infrastructures of European interest (H2020-INFRAIA-2014-2015, 2014)
Start date: 2015-09-01
End date: 2019-08-31
Duration (months): 48.0
Total project cost (EUR): 9979376.17
EU funding (EUR): 9979376.17
Participants: 30
Project status: CLOSED

HYDRALAB is an advanced network of environmental hydraulic institutes in Europe, which has been effective in providing access to a suite of major and unique environmental hydraulic facilities from across the whole European scientific community. A continuation project will prepare environmental hydraulic modelling for the upcoming urgent technical challenges associated with adaptations for climate change. A multi-disciplinary approach is essential to meet these challenges. We denote the project HYDRALAB+, in recognition of the added value that will follow from our network changing to enhance the collaboration between specialists and engaging with a new range of stakeholders. The issues associated with climate change impacts on rivers and coasts are significant enough to ask the scientific community to which we open up our facilities to focus their research efforts on adaptations for climate change. We plan to issue themed calls for proposals for access to the facilities, with scientific merit as the main selection criterion, but with preference to the proposals that also address issues of adaptation to climate change impact. In HYDRALAB+, with the prospect of climate change, we will build networking activities that will also involve the wider hydraulic community in the process of generating the deliverables of the project. The first Workshop in the project will be devoted to working together with the larger European hydraulics community not directly involved in HYDRALAB. Increased emphasis will be placed by HYDRALAB+ on engagement with industry – a theme that will be delivered initially through the vehicle of a focussed Workshop between HYDRALAB researchers and industry. We will work together with industry to have HYDRALAB+ become part of the innovation cycle by bringing development to market – this is particularly relevant for the instruments we develop - to involve industry in our range of project deliverables.

Keywords: environmental hydraulics,major and unique facilities,adaptation to climate change,data exchange
A Distribution and Monetisation Ecosystem for Mobile Applications, Maximising Market Growth through Affiliation (Gamesmondo)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-2-2015, 2015)
Start date: 2016-05-01
End date: 2018-10-31
Duration (months): 30.0
Total project cost (EUR): 2711125.0
EU funding (EUR): 1897787.5
Participants: 1
Project status: CLOSED

Flexion Mobile’s Gamesmondo project targets the Android segment of the mobile games market, forecast to exceed €35 billion per annum by 2017. The project, currently in TRL 6, is a major part of Flexion’s long-term strategy to build an open and fair market for Android games. The Android operating system is open. Hundreds of potential distribution channels exist and new entrants want to get involved in games distribution. In practice Android is currently dominated by one store. This is due to Google’s dominant position and freemium games’ dependency on features provided by the distribution channel. Supporting multiple channels means developers need to create and maintain multiple builds and relationships. In today’s market: • Developers are locked in to Google Play which is overcrowded, with limited discovery forcing them to spend heavily on advertising • Remaining distribution channels suffer due to a lack of content • Developers’ payment monetisation is limited to what Google’s payments can support • Non-Google distribution channels are effectively locked out of the market An open market, where developers can distribute games in any channel (including Google Play) would drive overall industry growth and reduce issues for developers. Gamesmondo combines enabling technology, commercial relationships, monetisation and service management to create an aggregated network of games, distribution channels and users. This overcomes fragmentation and opens up the market without opportunity cost. Developers get routes to users otherwise unreachable. Distribution channels get access to games and revenue otherwise unavailable and new players can enter the market. Gamesmondo will define a new set of tools, rules and methods for both developers and end users, whilst building a versatile foundation for benefiting from a growing market and successfully shrinking inequality by Google Play.

Keywords: mobile games,android ecosystem,google,google play,aosp,game developers,game,monetisation,monopoly,game distribution,competition
CoHerent AMplification and PArametric GeNeration of Euv radiation (CHAMPAGNE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Czechia
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 154720.8
EU funding (EUR): 154720.8
Participants: 1
Project status: CLOSED

The coherent extreme ultra violet (EUV) pulses produced via high harmonic generation (HHG) in gases are now the main workhorse for various applications of atomic physics and physical chemistry. As the generation efficiency is very low, the number of applications is limited by the low EUV photon flux. The main ambition of this project is to perform a coherent parametric amplification of the EUV pulses in order to significantly increase the EUV photon flux. Such an achievement would be an enabling technology causing a breakthrough in the field of atomic physics, physical chemistry, biology, material science and probably other fields as well. Applications suffering from poor signal/noise ratio will become widespread as they will not be limited anymore to research labs where the EUV sources are optimized daily. Moreover, higher photon flux opens completely new physics, as the EUV nonlinear optics becomes widely accessible and two-EUV-photon absorption turns out to be routine. Very recently a theoretical study was published on high order parametric generation based on the same number of infrared photons absorbed as in “standard” HHG. However, in contrast to HHG, 3 photons are emitted. We have already obtained preliminary data that suggest the presence of EUV photons of slightly lower energies than those originating from HHG. The photon energy difference corresponds to two photons from THz part of the spectrum and is in agreement with the theory. In the project, we identify our major objectives as work packages: WP1: Detection and optimization of the parametric EUV signature in HHG EUV spatially-resolved spectra. WP2: Study on detection of the THz field originating in HHG. WP3: Injection of externally generated THz beam to boost the high parametric process leading to amplification of EUV.

Keywords: high harmonic generation,high order parametric amplification of euv