Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Follow your scientific passion and join us tonight on Researchers’ Night. (FUSION2NIGHT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Poland
Call: European Researchers' Night (H2020-MSCA-NIGHT-2016, 2016)
Start date: 2016-05-01
End date: 2017-12-31
Duration (months): 20.0
Total project cost (EUR): 144700.0
EU funding (EUR): 144700.0
Participants: 3
Project status: CLOSED

Marie Curie once said I am among those who think that science has great beauty. If you wish to explore this beauty you don’t need a PhD, yet very welcome is a great deal of curiosity, imagination and a fine handful of patience. Then, just follow your scientific passion and join us at Fusion2Night and play a researcher for a Night or... more! In September 2016 and 2017 Institute of Animal Reproduction & Food Research, University of Warmia&Mazury, and JR School of Higher Education will change Olsztyn into the arena for bonding of researchers and general public, combination of education and entertainment, partnership of academic and industrial centres, and fusion of science disciplines. The topics will range from cutting edge research to unusual perspectives on science, including technology of 7D cinema, neuroscience behind therapy fairytales and pocket-fitting tests on celiac disease. From the morning hours, in a myriad of edutaining activities spread over the entire City, people of all ages will experience how every aspect of our life is possible thanks to scientific influences. With the rule: Tell me and I’ll forget. Show me and I’ll remember. Let me do and I’ll understand!, we will invite kids to try their hands at mind-exciting experiments and see how cool science is. Young people about to embark on career will have a chance to interact with and have their curiosity ignited by scientists, seeing them as ordinary people with extraordinary job. The stereotypic image of a scientist-alienated and immersed in intellectual puzzles having no bearing on others’ lives-will be confronted with inspiring academic and industry experts, communicating tangible benefits of their research and showing how rewarding science careers are. During face-to-face meetings at EU corner, researchers will promote the MSCA action as a passport to successful scientific career, stimulating pupils to consider their future in science and hence have a chance to co-create the world we all live in.

Keywords: passion in science,reduction in the stereotypes about researchers,benefits that research brings to society,hands on experiments,edutainment
An innovative polymer particle used for textile dying which massively reduces water and energy consumption (H2COLOR-AUX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Portugal
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2019-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The textile industry is a major contributor to global water consumption . In India alone, 1.6 billion litres of water are used daily in the textile industry. Given that only 2.5% of the Earth’s water is freshwater and only 0.3% is accessible to humans, this is clearly unsustainable and grossly wasteful. In addition, industrial manufacturing in the textile industry is responsible for 20% of all water pollution making it the number one polluter of clean water after agriculture. The dyeing process is the prime contributor to much of the water, time and energy consumption that takes place in the textile industry. On average, 60-80 litres of water are needed to dye 1kg of cotton and 80% of the total energy and 65% of the many environmentally hazardous chemicals produced in textile production are a result of the dyeing process. In addition, dyeing is also by far the most time-consuming process involved. Growing populations and consumer needs are demanding more efficient and faster production than ever. Our solution is an auxiliary technology, H2COLOR AUX. A revolutionary system developed by expert chemists that prevents hydrolysis in the dyeing process. This greatly reduces the amount of energy, chemicals and time required for dyeing textiles. A similar technology is used in our H2COLOR pigments which have superior properties than alternatives, while being less toxic and more environmentally sustainable. Upon commercialisation, we will save the world billions of litres of water per day, eliminate a globally leading polluter, increase textile production by 50%, and reduce costs for a multitude of industries. Customers of Ecofoot will have access to a highly-efficient, affordable, and easy-to-use dye-auxiliary product that saves 70% of the water, 80% of the energy, 50% of the process time, and 30-40% of the costs along the dyeing process. Customers using our product increase the sustainability of the textile industry and promote green environment technology.

Keywords: s textile dyeing,silica particles,encapsulated dyestuff,production process
Mechanisms of symbiotic incompatibility in the arbuscular mycorrhizal association (SYMBIO-INC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

Understanding the mechanisms that control symbiotic incompatibility is fundamental to evaluate biological factors that delimit symbiosis on Earth and could help us to improve symbioses for practical applications. In terrestrial ecosystems, about 29% of vascular plants, including the plant model Arabidopsis, apparently lost or suppress their ability to host symbiosis with the arbuscular mycorrhizal (AM) fungi, one of the most ancient and functionally important symbiosis on Earth. Yet, the molecular mechanisms that control this symbiotic incompatibility are largely obscure, which is limiting our ability to consistently predict the conditions that constrain AM symbiosis and to engineer new symbiotic partnerships. SYMBIO-INC addresses the challenging question of what are the key molecular constraints that prevent AM fungi from developing functional associations with land plants. Unlike traditional approaches, SYMBIO-INC will employ an interdisciplinary strategy focused on direct evidence with unprecedented emphasis on fungal traits during interactions with Arabidopsis plants differing in hosting phenotypes. Genotypic and molecular aspects will be evaluated for their potential to control Arabidopsis susceptibility to fungal colonization. The hypothesis that fungal nutrition is critical during incompatible interactions will be tested here for the first time. Finally, powerful transcriptomic tools will be employed to deliver a holistic overview of fungal molecular responses under different degrees of compromised symbiotic development. This horizon-broadening approach, combined with the maturity of our knowledge in the topic, supported by a robust set of new preliminary data, makes the proposed research a timely opportunity for paradigm shifting and high impact. Finally, SYMBIO-INC will allow the researcher to reinforce and further expand skills and expertise, create new collaborations, and forge a successful career aiming at a future tenure-track position.

Keywords: arbuscular mycorrhiza fungi,common mycorrhizal network,symbiosis,non host,arabidopsis,incompatibility,molecular constraints,genotype,fungal nutrition,fatty acids,fungal transcriptome
Statistically combine climate models with remote sensing to provide high-resolution snow projections for the near and distant future. (CliRSnow)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2021-09-12
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

The cryosphere in the European Alps is expected to change substantially with global warming. Snow in the Alps impacts the local communities but also affects the quantity and seasonality of water downstream, and thus has a wide range of effects on agriculture, ecosystems, hydropower, and tourism. Projections of future snow are required in society and economy. Targeted actions require information at the local community scale, which is not yet consistently available for the whole Alpine region. This is because the existing approaches to infer future snow conditions rely on physical models, either regional climate models (RCMs) or snow-hydrological models, which are both computationally very intensive, making it yet impossible to have a high resolution output for such a large area as the Alps. Here, I shall employ empirical models derived from remote sensing (RS) to provide an innovative and fast solution to increase the precision in future projections of snow cover from RCMs for the whole Alpine area. This will be achieved by correcting the bias in snow cover from RCMs and increasing the spatial resolution with RS snow cover data. Such an approach has now become feasible, because the data that forms its basis is on the verge of being sufficient in time (RS: MODIS time series since 2000) and space (RCM: EURO-CORDEX horizonzal resolution at approx. 12.5km). The host has the necessary data (daily MODIS snow cover at 250m and output from 15 different RCMs with snow cover), the technological environment for the computational demand, and the relevant expertise in each discipline (remote sensing, climate, hydrology) inside the institute and with international partners. I shall bring the statistical background, data handling skills, and interdisciplinary experience to combine these fields. This fellowship shall pave the way for my future career as independent researcher, but also produce output ready for re-use and exploitation by stakeholders in the Alpine countries.

Keywords: regional climate models,modis,remote sensing,snow cover,statistics,european alps,cryosphere,alpine hydrology
Stability conditions, Donaldson-Thomas invariants and cluster varieties (StabilityDTCluster)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-10-01
End date: 2021-09-30
Duration (months): 72.0
Total project cost (EUR): 1556550.0
EU funding (EUR): 1556550.0
Participants: 1
Project status: CLOSED

This proposal is concerned with the homological properties of Calabi-Yau threefolds, the geometric structures which play a crucial role in string theory. Rather than working directly with categories of sheaves, we focus on a closely-related class of models defined using quivers with potentials, which have themselves been the subject of intensive research over the last decade. Associated to a quiver with potential are two complex manifolds: the space of stability conditions and the cluster variety. Recent work by physicists Gaiotto, Moore and Neitzke suggests that there is a remarkable geometric relationship between these spaces, involving Donaldson-Thomas invariants and the Kontsevich-Soibelman wall-crossing formula. Work by the PI and others over the last couple of years has paved the way for a rigorous mathematical understanding of this relationship. This has the potential to open up new vistas in algebra and geometry, as well as greatly enhancing our understanding of the mathematics of quantum field theory. Our proposal combines powerful general constructions with specific computable examples. We will work initially with a class of examples related to triangulated surfaces; here the relevant spaces can be identified with familiar objects in the topology of surfaces, including moduli spaces of quadratic differentials, projective structures and local systems. These examples already involve deep mathematics, and are closely related to quantum field theories of current interest in theoretical physics. This proposal involves an unusually wide range of mathematics. Our ambition is to assemble a team of 4 research assistants having a sufficiently broad expertise to make progress on this exciting multi-disciplinary project. The PI is in a perfect position to lead such a team: he invented stability conditions, carried out important work on Donaldson-Thomas invariants, and proved a major theorem which forms one of the starting points of the proposal.

Keywords: homological algebra,representations of quivers,derived categories,ordinary differential equations,mirror symmetry,riemann surfaces
HIgh throughPut LasER processing of DIamond and Silicon (HIPERDIAS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Germany,Ireland,Germany,Germany,Switzerland,Belgium,France,France,France,United Kingdom,United Kingdom,United Kingdom
Call: Photonics KET (H2020-ICT-2015, 2015)
Start date: 2016-02-01
End date: 2019-10-31
Duration (months): 45.0
Total project cost (EUR): 4440640.0
EU funding (EUR): 3640307.5
Participants: 13
Project status: CLOSED

Driven by the end-users requirements and needs, the main objective of the HIPERDIAS project is to demonstrate high throughput laser-based manufacturing using high-power, high-repetition rate sub-1ps laser. Although the laser system to be developed within HIPERDIAS can address other material processing applications, the focus here will be 3D structuring of silicon at high-speed, precision processing of diamond material and fine cutting of metal for the watch and the medical industry. Chirped Pulse Amplification (CPA) approach based on highly efficient compressors gratings will be implemented in order to minimize the overall losses of the laser system. The final targets of the project are to demonstrate: - a 10-times increase of ablation rate and productivity of large area 3D-structuring of silicon - a 10 times increase of speed in fine cutting metals - an increase of process speed (6-10 times) at a low processing tools cost of diamond machining Therefore, the laser parameters, as well as the beam shaping, beam guiding (based on Kagomé fibers) and machine systems will be developed and optimized to fulfill the above manufacturing targets. The laser architecture will be based on fully passive amplifier stages combining hybrid (fiber-bulk) amplifier and thin-disk multipass amplifiers to achieve sub-500fs at an average output power of 500W and sub-1ps at an average output of 1kW, at a repetition rate of 1-2 MHz. Furthermore, second harmonic generation (SHG, 515 nm) and third harmonic generation (THG, 343 nm) will be implemented to allow processing investigation at these wavelengths. At 515 nm (respectively 343 nm) an average power of >=250W (respectively >=100W) shall be demonstrated.

Keywords: fiber beam delivery,ultrafast lasers,high efficiency grating compressors
Thermal Magnetic Resonance: A New Instrument to Define the Role of Temperature in Biological Systems and Disease for Diagnosis and Therapy (ThermalMR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 2043804.98
EU funding (EUR): 2043804.98
Participants: 1
Project status: SIGNED

Temperature is a physical parameter with diverse biological implications and crucial clinical relevance. With an ever increasing interest in thermal applications, non-invasive in vivo methods to modulate temperature and characterize subsequent effects are imperative. Magnetic resonance (MR) is a mainstay of diagnosis but lacks inherent means for focal thermal modulation. Ultrahigh field (UHF) MR employs higher radio frequencies (RF) than conventional MR and has unique potential to provide focal temperature manipulation and high resolution imaging (ThermalMR). Our simulations show that we can adapt an UHF- MR device to generate heat in highly focused regions of tissue by using high-density RF transmitter arrays. This new instrument will provide a revolutionary method for precise in vivo temperature manipulations. To establish high-fidelity thermal dosimetry, we will investigate pioneering strategies that exploit electrical and heat transfer tissue properties. For thermal dosage control, novel methods of MR thermometry will be developed. The capacity of ThermalMR for thermal intervention will be demonstrated in model systems. Its efficacy for drug release will be explored using new thermo-responsive nanocarriers loaded with fluorinated probes, exquisitely quantifiable with 19F MR. The applicability and safety of ThermalMR will be demonstrated in animal models followed by a feasibility study in healthy subjects. To link thermal responses of MR contrasts with molecular signatures, gene expression profiling will be performed. The aim is to understand the thermal properties of healthy and pathological tissues and explore the use of temperature modulation as a therapeutic tool. ThermalMR will eradicate the main barriers to the study and use of temperature - a critical dimension of life that is of intense clinical interest, but so far very poorly understood. This approach opens an entirely new research field of thermal phenotyping: where physics, biology and medicine meet.

Keywords: biomedical imaging,magnetic resonance imaging mri,ultrahigh field magnetic resonance,radiofrequency antennae
Photoactivatable Sensors and Blinking Dyes for Live-Cell, Single-Molecule Localization Microscopy (HDPROBES)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Switzerland,Switzerland
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-10-01
End date: 2024-12-31
Duration (months): 63.0
Total project cost (EUR): 1498125.0
EU funding (EUR): 850171.19
Participants: 2
Project status: SIGNED

In this proposal, we introduce two new families of probes for live-cell super-resolution microscopy. The first class comprises small-molecule fluorescent sensors for detecting short-lived, small signaling molecules and active enzymes with single-molecule resolution. The spatiotemporal confinement of biological reactive molecules has been hypothesized to regulate various pathological and physiological processes, but the lack of tools to observe directly these microdomains of biochemical activity has precluded the investigation of these mechanisms. The ability to detect small signaling agents and active enzymes with nanometric resolution in intact live specimens will allow us to study the role of compartmentalization in intracellular signaling at an unprecedented resolution. Our studies will focus on detecting elusive reactive oxygen and nitrogen species directly at their sites of endogenous production. We will also investigate the subcellular distribution of protease activity, focusing on its role in non-apoptotic signaling. The second class of probes encompasses a palette of fluorescent dyes that switch continuously between dark and emissive forms. This dynamic equilibrium will enable the localization of single molecules in a densely labeled field without the need to apply toxic light for photoactivation. Based on a novel switching mechanism, we will prepare dyes of various emission wavelengths that blink in a controlled way. These dyes will allow us to perform, for the first time, super-resolution, multicolor, time-lapse imaging of live specimens over long time. Initial studies will focus on tracking a transcription factor that migrates from the endoplasmic reticulum to the nucleus to initiate a cellular stress response upon protein misfolding. These studies will provide spatiotemporal details of this important translocation, which takes more than one hour to occur and its observation at the single-molecule level is intractable with current super-resolution methods

Keywords: photoactivatable probes,single molecule localization microscopy,fluorescent sensors