Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecular strategies to treat inherited arrhythmias (EU-rhythmy)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Italy,Spain,Italy
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-11-01
End date: 2021-10-31
Duration (months): 72.0
Total project cost (EUR): 2314029.0
EU funding (EUR): 1334029.0
Participants: 3
Project status: CLOSED

Sudden cardiac death (SCD) is a leading cause of death in western countries: coronary artery disease is the major cause of SCD in older subjects while inherited arrhythmogenic diseases are the leading cause of SCD in younger individuals. After 25 years dedicated to research of the molecular bases of heritable arrhythmias, the PI of this proposal now intends to pioneer gene therapy for prevention of SCD: a virtually unexplored field. The development of molecular therapies for rhythm disturbances is a high risk effort however, if successful, it will be highly rewarding. The PI has envisioned an ambitious and comprehensive project to target two severe inherited arrhythmogenic diseases: dominant catecholaminergic polymorphic ventricular tachycardia (CPVT) and Long QT syndrome type 8 (LQT8). The availability of a clinically relevant model is critical to ensure clinical translation of results: the team will exploit an existing CPVT model and will engineer a knock-in pig to model LQT8. The PI and her team will investigate innovative strategies of gene-delivery, gene-silencing and gene-editing to the heart comparing efficacy of different constructs and promoters. The team will also carefully engineer novel gene-therapy approaches to avoid the development of regional inhomogeneity in protein expression that may facilitate proarrhythmic events. Such a comprehensive approach will provide a most valuable core of knowledge on the comparative efficacy of a broad range of molecular strategies on the electrical milieu of the heart. It is expected that these results will not only benefit CPVT and LQT8 but rather they will foster development of gene therapy for other inherited and acquired arrhythmias.

Keywords: arrhythmias,sudden cardiac death,inherited diseases,genetics,electrophysiology
Internet of Things Everywhere on Earth: a satellite based M2M solution (IoTEE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Germany,Germany
Call: Engaging SMEs in space research and development (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-02-01
End date: 2019-01-31
Duration (months): 24.0
Total project cost (EUR): 2607413.75
EU funding (EUR): 1825189.63
Participants: 2
Project status: CLOSED

IoTEE provides a unique approach to providing IoT services from space, enabling a doubling of Europe’s Space IoT market share from 5% today to 10% by 2020, representing a €700Bn market opportunity. Accelerating adoption of IoT allows earlier access to the economic and societal benefits from cheaper, more autonomous operation of very large networks of small devices, to address key challenges such as: environmental monitoring, food security, climate change risk mitigation, border security. IoTEE bridges a gap in the provision of M2M communications, particularly outside ‘smart cities’. The project further increases M2M security, and allows cheaper, more autonomous operation of very large networks of small devices. The IoTEE devices implement a unique new communication protocol, LP(U)WAN, extending the LPWAN benefits over satellite coverage distances with additional security. The consortium includes leading figures inside the Space IoT and Telematics industries, with deep experience of EU and ESA project management, autonomous device design and operation in demanding environments, and user requirements driven solutions. It is further backed by extensive technology and business networks, including support from strategic partnerships with ESA, German DLR and TZR. The implementation infrastructure for IoTEE utilises and enhances unique European generated technology and solutions (S4M TELDASAT Space M2M solution, the existing GTS hardware on the ISS, and an exclusive ITU license to use the GTS downlink frequency band). The project will generate €33M revenue and 100 direct jobs by 2026 plus an additional 200+ jobs in the surrounding ecosystem.

Keywords: lpwan,satcom
The Intelligent Service Network Operator (SERVONE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Finland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-03-01
End date: 2017-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The dynamic of today's IT business market demands 100% operations availability. Mission-critical applications and data centres are cashing-in huge company resources but the investments don't deliver the expected results. As many organisations face hardware and software downtime, IT failures have become regular aspects of company life. 59% of Fortune 500 companies experience a minimum of 1.6 hours of downtime per week, loosing €41.4M/year, as the resolution time often exceeds the tolerable 2 hours threshold. Nominated by Gartner as cool vendors in 2016 and supported by the innovation funding agency Tekes, at Service Flow we understand the limitations of current Information Technology Service Management solutions, especially in service cost, agility, availability and accessibility. As the ITSM market is projected to grow to €8.05 billion by 2021, organisations need cost-effective and reliable ITSM integrations. Within the EU Digital Society context, our project SERVONE brings the first SaaS solution providing the easiest and most reliable service by which ITSM and other service management systems can be integrated. All-inclusive and automated, it enables end-users and service providers to digitalise service processes through a simple Connect-Configure-Run process, giving 99.9% end-to-end availability. Service Vendors no longer need to set up the solution every time a new client is on-boarded. End-users benefit from automation, better management of multi-vendors and multi-customer environment, larger margins and standardisation. Starting from a reliable system but with limited capabilities at TRL6, we plan to bring our solution to a full commercial launch. The Feasibility Study will result in a detailed Business Plan we will use for global expansion by the third quarter 2018 after completing the Phase 2 project. We are planning a market reach across Europe, USA and Asia-Pacific by 5th year of commercialisation with a total revenue of €36.00m and ROI of 5 by 2021.

Keywords: service integration,software as a service,integration management,it infrastructure,it oursourcing
Developing a Non-Invasive Kit for Early Colorectal Cancer Detection (ColoFast)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Spain
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-07-01
End date: 2021-06-30
Duration (months): 48.0
Total project cost (EUR): 3190082.33
EU funding (EUR): 2817154.75
Participants: 1
Project status: CLOSED

Colorectal cancer (CRC) represents one of the most important health problems worldwide. Decreasing the mortality rate by CRC in Europe is a clear unmet need today. Medical community agrees that this number of CRC related deaths could be prevented by adequate screening programs for early detection. European authorities look for new strategies to address the clinical need for early diagnosis of CRC that will reduce patient care associated costs. Potential savings would be achieved if CRC patients were diagnosed earlier. The objective of this proposal is to validate and commercialize a novel, non-invasive, simple to use kit (ColoFastTM), regulatory approved for the diagnosis of CRC in blood. It is based on a new generation of leading-edge biomarkers that showed very high sensitivity and specificity for early detection of CRC in two prospective cohorts. The commercialization of the kit will have clear impact in improving survival of patients and reducing mortality by CRC cancer, with significant costsavings for National Health Services. It will be easily implemented in the clinical routine of the majority of European hospitals, with better acceptance of patients. ColoFast represents a significant business opportunity, addressing a clear unmet medical need in a large and expanding target population of 189M people in Europe in 2020, growing at 25%, with a significant global market of €1,616M in Europe, the US and Japan this year. It will have a huge impact on the growth of a SME as Amadix over the next 10 years, multiplying the team size by five in five years (41 employees in 2020). 2M European people will benefit from the test in 2024. Amadix turnover in 2021 will be €18 m, which will give our company a profit of €7 m in 2021. From this year on the company will be profitable. Overall, ColoFast will reduce mortality rate and treatment cost while improving quality of life in a cost-effective way, assisting also to fulfill European priorities for healthcare improvements.

Keywords: colorectar cancer,healthcare,in vitro diagnostic kit,early detection,rtqpcr,mirna,cost effective,plasma,premalignant lesions,advanced adenomas
Allergic multimorbidity from birth to young adulthood: determinants, epigenetic regulation and inflammatory processes (ALLERGENE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-03-01
End date: 2026-02-28
Duration (months): 60.0
Total project cost (EUR): 1493330.0
EU funding (EUR): 1493330.0
Participants: 1
Project status: SIGNED

The prevalence of allergic diseases, such as atopic eczema, asthma and rhinitis, has increased over the past decades and is currently estimated to be up to 40%. Prevention strategies play a pivotal role, as there are no curative treatments available. Therefore, the aim of ALLERGENE is to understand the complex interplay of genetic, environmental and lifestyle factors and to identify involved mechanisms that distinguish between young adults free of allergic diseases and those suffering from allergic multimorbidity. Therefore, the aims of the present project are to: 1. Define allergic disease trajectories from birth to young adulthood, describe their determinants and identify risk and protective early-life environmental and lifestyle factors contributing to progression towards allergic multimorbidity or remission of allergic diseases. 2. Investigate molecular mechanisms of epigenetic regulation of allergic disease trajectories and test effect modification by inclusion of selected environmental and lifestyle factors. 3. Characterise the underlying inflammation profile of allergic disease trajectories and determine interactions with environmental and lifestyle factors The project makes use of two long-standing, prospective German birth cohort studies, GINIplus and LISA, with available data from birth to young adulthood, and an extensive examination planned at age 25. Within this project, a comprehensive characterisation of allergic disease trajectories, their determinants, comorbidities, risk and protective factors across the life-course will be obtained. ALLERGENE will enhance the understanding of how modifiable factors contribute to allergic disease aetiology. This will be an essential prerequisite to develop effective early intervention strategies for susceptible populations and to identify disease-specific biomarkers for the development and progression of allergic diseases in the future.

Keywords: allergy,asthma,respiratory,children,adolescents,young adults,comorbidity,multimorbidity,epidemiology,birth cohort,methylation,gwas,inflammation
Enhancing Responsible Research and Innovation through Curricula in Higher Education (EnRRICH) (EnRRICH)

Framework: Horizon 2020 — Science with and for Society
Programme: Make scientific and technological careers attractive to young students, and forster sustainable interaction between schools, research institutions, industry and civil society organisations
Action type: Coordination and support actions
Countries involved: Germany,Ireland,Ireland,Italy,Spain,Germany,Hungary,Lithuania,Belgium,France,Netherlands,United Kingdom,United Kingdom
Call: Responsible Research and Innovation in Higher Education Curricula (H2020-SEAC-2014-1, 2014)
Start date: 2015-07-01
End date: 2018-03-31
Duration (months): 33.0
Total project cost (EUR): 1499396.63
EU funding (EUR): 1499396.63
Participants: 13
Project status: CLOSED

The Enhancing Responsible Research and Innovation through Curricula in Higher Education (EnRRICH) project will build the capacity of staff in higher education to facilitate their students’ development of knowledge, skills and attitudes and competencies in responsible research and innovation, and respond to the research needs of society, particularly underserved civil society organisations (CSOs). It will do this by identifying, developing, testing, and disseminating resources, based on existing good practice and trials of new initiatives, to embed the five RRI keys in academic curricula across Europe, with specific reference to science and engineering. It will develop case studies which showcase examples for students, teachers, professional trainers and academic staff of HEIs. Through ongoing dialogue with academics, policymakers, and CSOs, EnRRICH will kick start debates at institutional, national and international levels to create awareness of, and enhance the policy context for, RRI in curricula and thereby produce more responsible and responsive graduates and researchers. These objectives will be achieved building on the Public Engagement with Research and Research Engagement with Society (PERARES) and RRI Tools projects. It will involve new partners as well as a core of established partners drawn from HEIs and CSOs, including from RRI tools. It will establish an advisory board drawn from relevant organisations to ensure the widest possible engagement and dissemination. Work packages will deal with project management, state of the art of good practices in introducing RRI into curriculum development, exchange and trialling of good practices at national, international and transdisciplinary levels, policy development, evaluation, dissemination and a conference. Deliverables will include case studies and policy papers, and materials and resources for academic staff to involve students in experiential learning about RRI, including projects in partnership with CSOs

Keywords: community knowledge exchange,co creation of knwoledge
One device to measure the most important air pollutants and greenhouse gases at once (Envirolas)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-01-01
End date: 2022-09-30
Duration (months): 33.0
Total project cost (EUR): 1784677.5
EU funding (EUR): 1249274.25
Participants: 1
Project status: CLOSED

EU air monitoring authorities, industries and research centers struggle to acquire pollution data to develop concrete emission reduction strategies. To monitor each individual polluting gas, it is necessary to perform analyses in separate, bulky and expensive instruments, placed in fixed monitoring stations. These instruments face financial, logistical and data limitations, because they are expensive, not portable and require regular calibration and continuous operation by expert technical staff. At MIRO Analytical Technologies we have developed EnviroLAS, the first all-in-one instrument for advanced pollution monitoring, allowing the measurement of 6 different pollutants (CO, O3, SO2, NO, NO2, NH3) and 4 greenhouse gases (H2O, CO2, CH4 and N2O) continuously, simultaneously and precisely through a light and easily transportable device based on direct laser absorption spectroscopy. Our feasibility plan was developed under a Ph1 grant and now we seek an Accelerator grant to launch EnviroLAS into the market. During the project we plan to add key components to EnviroLAS hardware and upgrade our software and user interface. We will refine the present manufacturing process and define the industrial scale-up process, after performing external testing of EnviroLAS with early adopters. We will certify EnviroLAS in EU and US, and consolidate our exploitation plan, targeting all Europe by 2024 and expanding to US by 2026. EnviroLAS will have 75% less operational costs, 40% lower startup costs, and reduced dimensions (60x50x15cm) and weight (25kg) compared to existing devices. It will address the urgent demand to monitor main air pollutants and greenhouse gases in-situ in a more cost-effective and dynamic way. The EC contribution is fundamental to scale-up our business and create 27 new jobs in our company by 2026, to address our clients’ needs.

Keywords: air quality measurement,all in one instrument,dual color quantum cascade laser,portable instrument
Waste to Hydrogen (Waste2H2)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Italy,Sweden,Portugal
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 899718.75
EU funding (EUR): 899718.75
Participants: 4
Project status: SIGNED

The WASTE2H2 proposal field of action is hydrogen as a sustainable energy vector and waste valorization in a circular economy approach. Characteristically, Hydrogen can be produced using diverse resources including fossil fuels, such as natural gas and coal, biomass, non-food crops, nuclear energy and renewable energy sources, such as wind, solar, geothermal, and hydroelectric power to split water. Hydrogen could be produced from waste biomass by thermal gasification processes followed by clean and purification stages of syngas produced. This area has an enormous potential for society descarbonisation and development of circular economy. This diversity of potential supply sources is the most important reason why hydrogen is such a promising energy carrier. WASTE2H2 aims to enhancing the scientific and technological capacity of IPPortalegre in clean and purification of thermal gasification syngas in order to produced hydrogen, and at raising staff’s research profile and excellence by twinning with three well established and leading research institutions: Royal Institute of Technology, in Sweden; Italian National Agency for New Technologies, Energy and Sustainable Economic Development, in Italy and; Karlsruhe Institute of Technology, in Germany. This will allow mutual learning and knowledge transfer activities, cross-fertilization and networking opportunities and increased opportunities for research collaborations. The resulting enhanced capabilities and status of IPPortalegre, would in turn contribute to the change of its economic landscape, giving new opportunities for development and job creation, strengthening and enhancing the positioning of Portugal as an important player in applied scientific research in the respective field.

Keywords: syngas,waste to hydrogen,gasification
An avian model for understanding and preventing the negative effects of poor developmental conditions on subsequent health state, fertility and ageing rate (DAMAGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-02-01
End date: 2018-01-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Poor developmental conditions have been shown to impact subsequent health, fertility and lifespan, both in human and animal models. However, the molecular, developmental and physiological mechanisms underlying these adverse effects on health later in life are still poorly understood. Since mammalian models do not allow manipulations of embryo development independently of maternal influence and nutritional state (i.e. without the mother potentially compensating for any manipulation), I will pioneer a new avian model using experimental controls of embryo growth and development through modulation of incubation temperature. The key goals of this postdoctoral project are: (i) To determine the extent to which developmental conditions (i.e. slow vs. fast embryo growth rate, developmental instability) induce deleterious effects on health, fertility and rate of ageing in later life. (ii) To identify the molecular and/or physiological mediators of such adverse effects, by targeting parameters related to the ageing process (mitochondrial functioning, oxidative stress, telomere erosion and cellular stress resistance) and investigating the ‘sparing of vital organs’ hypothesis. (iii) To test both pre- and post-natal antioxidant therapies as preventive strategies to limit the deleterious impact of poor growth conditions on subsequent health, fertility and rate of ageing. This project will use a novel approach to reveal completely new insights into the importance of developmental conditions for subsequent life-history trajectories and rates of ageing. It will also provide important insights for the poultry industry about the impact of developmental conditions and in ovo antioxidant supplementation on subsequent productivity and fertility.

Keywords: fetal programming,bird,oxidative stress,telomere,mitochondria