Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Contentious Rights: A Comparative Study of International Human Rights Norms and their Effects on Domestic Social Conflict (CONRICONF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United States,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-17
End date: 2020-02-08
Duration (months): 36.0
Total project cost (EUR): 269857.8
EU funding (EUR): 269857.8
Participants: 3
Project status: CLOSED

Contentious Rights: A Comparative Study of International Human Rights Norms and their Effects on Domestic Social Conflict Over the last 60 years, a broad set of international norms gained importance as instruments to regulate a globalising world. Enshrined in human rights conventions, these norms contribute to strengthen a platform for social mobilization and voice. The introduction of human rights standards at the domestic level, however, has also been responsible for the generation of new tensions on the interpretation and application of these norms. Yet, this type of conflict and polarization among social and political actors remain widely unexplored. This project will examine how ‘human rights act in practice’ in the post-ratification phase using a multidisciplinary perspective and an empirical comparative approach. More precisely, it addresses the task of identifying the conditions under which international norms generate consensus and cooperation or fragmentation and conflict between domestic social and political actors and the consequences in terms of human rights practices. The candidate fellow Dr. Lorenza Fontana will focus on a comparative analysis of two conventions (International Labor Organization’s Conventions 182 on Child Labor and 189 on Domestic Workers) in two countries (Bolivia and Philippines) and lead an interdisciplinary collaboration between Prof. Jean Grugel (University of Sheffield, SIID), and Prof. Beth Simmons (Harvard University, WCFIA). This project will greatly increase our understanding of the effects of human rights norms on domestic societies and provide policy relevant results.

Keywords: human rights,social conflict,international conventions,civil society,domestic politics,children rights,domestic workers rights,bolivia,philippines
World’s first absorbable percutaneous closure device for large venotomies (VENOCLOSE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-05-01
End date: 2023-03-31
Duration (months): 35.0
Total project cost (EUR): 3886887.5
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Small venotomies (a hole in the vein to provide access for surgical procedures) are routinely made and closed using manual compression. As venotomies get bigger it becomes more difficult to close them, leading to complications (blood loss, haematoma, infection and thrombosis). Developments in transcatheter heart valve procedures and left atrial appendage occlusion requires large venotomies in the femoral vein to gain access to the heart. These large venotomies are difficult to close, leaving patients exposed to additional complications, pain and discomfort. Hence, there is a strong unmet medical need for effective methods to close venotomies. Vivasure Medical Limited is a Irish R&D performing medical device company, established in 2008 and secured a total of €45M funds. Vivasure developed the patented PerQseal platform technology as effective method for large arterial and venous closures. PerQseal Venous is the world’s first absorbable patch-based closure product for large venotomy closure (over 8 mm). By delivering an intra-venous patch without surgery, a surgeon can seal vessels from inside while providing a matrix to support wound healing. PerQseal Venous is largely based on Vivasure’s already existing and well-validated PerQseal®Arterial product, used to close arterial vessels and already in clinical use. Following clinical validation and preparation for EU and US wide commercialisation in the VENOCLOSE project, Vivasure will target the large and ever-growing venous closure market. Vivasure has successfully obtained ISO13485 Certification and CE certification for its arterial closure device, which will pave the way for PerQseal Venous. The company will leverage existing customer-base among cardiologists and distribution partner, contributing to a further de-risking of PerQseal Venous commercialisation. Obtaining €2.5M in EIC-Accelerator funding will accelerate the road to market for PerQseal Venous, and lead to direct revenue and employment growth at Vivasure.

Keywords: cardiovascular surgery,valve replacement,biodegradable implant,vessel closure,venotomy
Reconstructing the Effect of Sulfide Respiration on Global Redox State: Insights from Experiments, Observations, and Models (RESpiReS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 2460062.0
EU funding (EUR): 2460062.0
Participants: 1
Project status: SIGNED

To comprehensively reconstruct the evolution of Earth's climate, atmospheric and seawater chemical compositions, and conditions that favor the proliferation of life, it is critical to constrain all atmospheric carbon dioxide (CO2) and oxygen (O2) sources and sinks—including their dependencies on underlying environmental and geologic drivers. One major CO2 source and O2 sink remains poorly understood: oxidative weathering of sulfide minerals (e.g., pyrite) on land. In addition to driving Earth's atmospheric composition, pyrite oxidation potentially provides a quantitative proxy for recording past O2 and CO2 levels: the triple-oxygen isotope composition of sulfate. Still, three key questions remain unanswered: (i) what sets the modern-day pyrite oxidation flux, (ii) how has this flux changed over million- to hundred-million-year timescales, and (iii) do geologically preserved sulfate isotopes faithfully record past atmospheric conditions? Here, I outline a multifaceted research program to answer these questions. This research will develop and apply novel experiments and state-of-the-art geochemical tracers to mechanistically understand pyrite oxidation and resulting sulfate isotope signatures. These results will inform theoretical, kinetic, and numerical models to quantify pyrite oxidation fluxes and atmospheric compositions throughout Earth's history—this combination of techniques is uniquely afforded by my background and expertise. Specifically, this research will: (i) constrain the electrochemical mechanism of pyrite oxidation and its isotopic consequences, (ii) assess which environmental and geologic controlling factors govern pyrite oxidation rates and fluxes, and (iii) determine how secondary redox cycling in the environment overprints sulfate isotope signatures. An ERC Starting Grant will enable me to access the outstanding human resources and scientific infrastructure available at ETH Zürich in order to address this major open questions in modern geochemistry.

Keywords: atmospheric composition,biogeochemical cycles,carbon,oxygen,sulfur cycle,carbon dioxide,earth history,erosion,paleoclimate,pyrite oxidation,stable isotopes,triple oxygen isotopes,weathering
Deformable vascular registration for co-mapping altered hemodynamics with vascular responses, and for introducing a new measure for aneurysm rupture risk assessment: the local surface growth (VASCFORM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

Growth rate of ascending aortic aneurysm (AsAA) is a rupture risk marker as it potentially reflects a wall remodeling that leads to fast growth. It is measured as the maximum diameter change over time. However, expansion is not uniform but presents localized growth. We propose to develop a methodology based on deformable surface registration tools that will provide correspondence between aortic surface meshes obtained at consecutive time points and quantify vascular surface growth distribution. The direct application of this methodology in animal and clinical research will answer some long debated questions about AsAA pathology. While a cause and effect relationship between hemodynamics and lesion development is long suspected, exact quantification of the responsible hemodynamic factors has not been performed so far. This is because the geometry changes between baseline (measurement of initiating hemodynamics with computational fluid mechanics) and end stage (lesion development), making it difficult to identify corresponding regions at the microscopic level of lesion size. We will use angiotensin II-infused ApoE-/- mice, a model for AsAA, and apply the developed registration methodology to obtain a detailed correspondence between the 3D images, and co-map the complex initiating hemodynamic microenvironment and the histological findings at sacrifice for the identification of disturbed hemodynamics. Furthermore, the local wall expansion can indirectly provide information about aneurysm state. We will associate maximum local growth with the degree of aneurysm initiation (size of media tear) which will be used as a groundwork and pre-clinical justification to introduce the regional growth measurement in clinical risk assessment. Lastly, clinical data from AsAA patients will be used in order to correlate the maximum regional growth with clinical outcome, which will establish a new metric for a more sensitive aneurysm growth quantification.

Keywords: non rigid registration,computational fluid dynamics,ascending aortic aneurysm,apoe,mouse,model
AnchorBuddy™ is an intelligent and reliable anchor monitoring safety device that gives you a peace of mind while anchoring. It is a plug and play solution mounted directly on the anchor itself. (AnchorBuddy)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: SME instrument
Countries involved: Slovenia
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2018-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

AnchorBuddy™ - intelligent anchor monitoring device - project addresses the crucial need of sailors of all backgrounds (the potential users), to improve the reliability and general experience of anchoring. According to gathered feedback while being present on the charter market for 20 years, the number one requested user need is a reliable anchor alarm. AnchorBuddy™ is an intelligent and reliable safety device that gives you a peace of mind while anchoring. It is a plug and play solution. AnchorBuddy™ is mounted directly on the anchor itself. It detects and analyses anchor movement on the seabed. Nautical tourism is one of the global booming economical activities. Contrary to the development of the yachting industry, the anchoring methods have remained largely unchanged through centuries. Considering the crucial safety aspect of anchoring and the inherent weaknesses that all types of anchors have in common, there is a great need for improvement. We believe that anchoring incidents should be a thing of the past. The anchoring accessories available on the market are mostly inadequate software solutions based on technology that was not specifically designed for anchoring. With this in mind, we started the AnchorBuddy project, which could radically change the way we approach anchor monitoring today. By using specifically designed, modern technology, AnchorBuddy allows its users to precisely detect any significant movement of the anchor. However, AnchorBuddy will not stop there. The JUNIBA company was established in 1997 as a company for environmental and quality of life research. We have always been highly focused on the environment and, hence, we will also gather information about pollution and use the gathered data to reduce maritime littering. We believe that our product has high appeal to both novice and experience.

Keywords: blue,growth,connected boat,sensors,safety,tourism
Europe and Its Central Banks: Lessons from History (EUROCBH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

Will central bank independence continue? In economic literature, there is a large consensus that the optimal statute for a central bank should be founded on the principles of independence and price stability. Over the past 30 years, most central banks across the advanced economies have been given the ability to conduct monetary policy independently from interference by fiscal and political authorities. In the post financial crisis era, however, central banks in many countries have been entrusted with the formulation of measures of ‘unconventional’ monetary policy going beyond their traditional mandates. Historical evidence reminds us that for many decades and especially after crises central banks have been heavily involved in industrial finance and the holding of government debt, but in ways that are often ignored. This was at least the case in France and Italy. The aim of EUROCBH (Europe and Its Central Banks: Lessons from History) is to place the question of the independence of the central bank in a historical perspective, shedding light on the evolution of the Bank of France and the Bank of Italy from the late 19th century to WWII. The activity of EUROCBH will be organized around four main research questions: 1) What was the role of the the central bank in fostering long-term investment and absorbing economic (and financial) shock in Italy and France? I will look at long term and targeted lending, and massive purchase of government bonds as "unconventional” measure of the central bank. This is the main question to which the others are all connected. 2) What were the similarities and the differences between the central banking experimentations of these two countries? 3) What we can learn from the comparison? Overall the project will lead to a better knowledge of central banking in the past, which is also expected to help understanding the re-opened debate surrounding the legitimacy, and the precise scope of central bank independence after the crisis.

Keywords: central banking,xx century,italy,france,central bank independence,industrial policy,crises
INNOWAY Key Account Manager and Innovation Specialists Services - NORIMS (NORIMS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Norway
Call: ENTERPRISE EUROPE NETWORK H2020 ASSOCIATED COUNTRIES (H2020-EEN-GA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 201503.75
EU funding (EUR): 201503.75
Participants: 1
Project status: CLOSED

The NORIMS project shall strive to enhance the innovation management capacity of Norwegian SMEs in 2019 by reducing barriers to innovation and to ensure that more great ideas will reach the market. The two distinct types of services under this consultation, a) Key Account Management under the SME beneficiaries of the SME Instrument and FTI and FET-Open under H2020 and b) Services to enhance the innovation management capacity of SMEs will be offered as an integrated part of the general support services of the Enterprise Europe Network Business Cooperation Centre (BCC) in Norway in 2019.

Keywords: innovation management capacity,key account manager,innovation specialist,enterprise europe network,business cooperation centre,fet open,smbi
Integrated next-generation flow cytometry and sequencing to uncover the pathway of curability in multiple myeloma (MYELOMANEXT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Spain
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2022-02-28
Duration (months): 66.0
Total project cost (EUR): 1468606.0
EU funding (EUR): 1468606.0
Participants: 1
Project status: CLOSED

Multiple myeloma (MM) represents a unique model to investigate cancer stem cells (CSCs), circulating tumour cells (CTCs), and the mechanisms of malignant transformation and chemoresistance. Despite the substantial improvement in MM patients’ outcome, the vast majority of patients eventually relapse and the disease remains largely incurable. For those patients failing to achieve deep remissions, biologically targeted research on the ultra-chemoresistant minimal residual disease (MRD) clone may allow us to understand the cellular mechanisms driving chemoresistance, and design novel therapeutic to overcome; importantly, such effort should be equally performed on two additional key players: CSCs and CTCs. On the opposite side, it is unquestionable that a selected group of patients does experience long-term survival irrespectively of the depth of response achieved, but we fail to understand the mechanisms driving sustained disease control. Is it because of persistent residual benign clones? Is it because of immune surveillance? Here, we will integrate next-generation flow cytometry and sequencing to define i) the signature of CTCs and ultra-chemoresistant MRD cells, ii) the hierarchical place of putative CSCs, iii) the genomic landscape of benign vs. malignant clones; and iv) the role of immune surveillance to achieve functional cures. Hence, we will characterize for the first-time-ever the highly-professional subclones responsible for malignant transformation, disease dissemination, and dramatic relapses after optimal response to therapy. Noteworthy, the innovative approach of this scientific proposal strongly relies on the use and expertise of highly-sensitive next-generation flow cytometry, coupled with optimized DNA- and RNA-sequencing for low-cell-numbers, and prospective patient samples longitudinally available within the scope of well-controlled clinical trials. Herein, we believe that all requirements are met to conduct this ground-breaking research program.

Keywords: multiple myeloma,minimal residual disease,circulating tumour cells,cancer stem cells,flow cytometry,next generation sequencing
A Nano-photoelectric Exosome Biosensor for Point-of-care Diagnosis of Early-stage Cancer (ExoSensor)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-11
End date: 2019-10-10
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Tumour-derived circulating exosomes are an ideal, easily accessible reservoir of cancer biomarkers to assess disease processes. Quantitatively pinpointing exosome tumour markers, a clinical field of an unmet need is appealing, yet challenging. The main objectives of the proposal are to develop an integrated dual-signalling exosome biosensor (ExoSensor) for rapid and specific detection of GPC1+ exosomes and fabricate a 3D-printed portable prototype for POCT diagnosis of pancreatic cancer, offering an universal technology for clinical cancer diagnosis through quantitatively monitoring the protein marker of cancer-derived exosomes, in a simple way. The novelty resides in creatively achieving accurate, sensitive, and simultaneous detection of exosomes by integrating two synergetic methods (optical and electrochemical) on one single nanosensing platform, avoiding false positive/negative results to the utmost and ensuring the reliability of tests. This European Fellowship at Kings College London will provide the researcher with advanced technical training in molecular biology, exosome, cancer cell and animal handling, analytical chemistry and microscopy and imaging techniques, as well as academic mentoring in research management. A secondment to Cardiff University will seek and confirm the best possible biomarker(s). Another secondment to the industrial partner AstraZeneca Ltd will offer access to various exosomes research (diagnostics, toxicology and therapeutics) and evaluate the feasibility of commercial transfer if possible. Guy’s, St Thomas, and King’s College Hospital (part of King’s Health Partners) will provide valuable clinical samples for final validation stage. Other collaborators will advise on 3D-printing, pancreatic cancer and biomarkers. These interdisplinary contributions are essential and well-related to the proposal research, fostering high-quality cooperation from biology, chemistry, engineering, nanotechnology and clinical areas the other way round.

Keywords: exosome,poct diagnosis,pancreatic cancer,dual signalling,biosensor,early stage cancer detection