Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Quantum Tensor Engine (QTEngine)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-07-01
End date: 2025-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Quantum computers harness fundamental aspects of quantum behavior to drive exponential increases in the speed with which certain computations can be performed. They have potentially a tremendous long-term impact in areas such as quantum-many body physics and material science, and further afield in machine learning. The quantum many-body problems studied by condensed matter physicists are perhaps the most likely to yield early demonstrations of this potential. However, current and near-term intermediate-scale quantum (NISQ) devices are limited in the number of operations that they can carry out before their performance is degraded by interactions with the environment. To take advantage of these platforms and to outperform classical computers, highly efficient and specialized quantum algorithms are required. The implementation and benchmarking of these basic algorithms on different quantum computing platforms is challenging and requires a detailed knowledge of the underlying physics. Our approach is to produce a ready-to-use, highly innovative software package based upon quantum tensor networks. The Quantum Tensor Engine (QTEngine) will provide a unifying framework for both quantum and classical algorithms. The QTEngine will serve as an engine to drive fast and easy implementation of quantum simulation, quantum machine learning, and optimization algorithms. The anticipated user base include academic groups as well as commercial research and development groups.
enAbling EWS/GAlileo maRket uptake in widEspread PWS solutions (AWARE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: EU Space
Destination: EU Space
Action type: Innovation actions
Countries involved: France,Spain,Belgium,Slovenia
Call: EGNSS applications for Safety and Crisis management (HORIZON-EUSPA-2021-SPACE, 2021)
Start date: 2022-11-01
End date: 2026-05-31
Duration (months): 43.0
Total project cost (EUR): 3542648.23
EU funding (EUR): 2609341.25
Participants: 9
Project status: SIGNED

In 2023, the European Commission will launch the Galileo Emergency Warning Satellite Service (EWSS). EWSS is a worldwide service to broadcast emergency warnings linked to natural or man-made disasters, with the major advantage to remain operational when all terrestrial communication networks are down, and in places where they do not exist at all. Final recipients of EWSS messages (EWM) are primarily citizens equipped with Galileo enabled smartphones, but another category of end-users exists: Public Warning Systems (PWS) stakeholders. For this latter, a specific GNSS equipment is needed to receive and process the EWM, this equipment being integrated in fixed devices which alert citizens via audio, video and text alert messages (such as Long-Range Acoustic Devices or Digital Panels) or adequate digital messages flows within IT systems. The purpose of the AWARE project is to develop this specific GNSS equipment, also secured by the OS-NMA feature. AWARE will also prepare the adoption of EWSS by European Civil Protection Authorities by performing activities in support to EUSPA and EC for the service deployment, dissemination activities aiming at building the AWARE ecosystem within the PWS B2B and B2G markets. AWARE consortium gathers all the necessary competencies ensuring the success of the project with FDC as GNSS receiver manufacturer, Telespazio and EENA with experience on the design and deployment of public safety services (GRALLE, HELP112), CNES as operator of Toulouse SAR/Galileo Service Centre, where the EWSS service centre will be hosted. End to End demonstrations will be performed with JCDecaux and Genasys, PWS equipment providers and solution integrators, and will involve customers such as the Slovenian Civil Protection Authority. The bridge between Galileo EWSS and Copernicus EMS will also be showcased by UNISTRA. The draft business plan demonstrates the consortium commitment to go to the market and the high probability of a quick R.o.I.

Keywords: galileo,ews,pws,copernicus,os nma,gnss,public alerte
From niche to mainstream - alternative proteins for everybody and everywhere (LIKE-A-PRO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Innovation actions
Countries involved: Germany,Austria,Norway,Spain,Poland,Greece,Slovenia,Türkiye,Finland,Belgium,Netherlands,Denmark,Italy,France,Portugal,Czechia
Call: Building alternative protein-friendly sustainable and healthy food environments (HORIZON-CL6-2022-FARM2FORK-01, 2022)
Start date: 2022-11-01
End date: 2026-10-31
Duration (months): 48.0
Total project cost (EUR): 13664884.67
EU funding (EUR): 11999659.64
Participants: 46
Project status: SIGNED

The interest of Europeans in alternative proteins is becoming clear and this trend is the perfect ground for the dietary shift towards sustainable and healthy nutrition and food systems, in line with the ambitions of the EU Green Deal, Farm to Fork strategy and EU’s climate goals. Yet, this interest is not reflected in the European dietary patterns, as alternative proteins are mainly consumed by early adopters, while the majority is less receptive towards alternatives or have limited possibilities to integrate them in the diets. This gap between interest and consumption is due to obstacles in the food environments such as product limited offering, suboptimal product taste, isolated product placement in shops or menus etc. Without overcoming these obstacles, alternative proteins will remain a niche. LIKE-A-PRO aims at mainstreaming alternative proteins, making them accessible, available, and acceptable to everybody (from children to elderly, vulnerable groups) and everywhere (across Europe, in urban, peri-urban, and rural areas). To achieve this, key representatives along the entire alternative protein value chain (growers, producers, cooks, retailers, consumers, researchers) will work together in a trans-disciplinary consortium. To improve European food environments towards fostering alternative protein consumption, practical solutions will be co-designed with citizens. This social innovation will take place in 11 living labs and in 4 real life food environments. For a diversified alternative protein offering, 16 new alternative protein products will be developed with 7 sustainable, healthy, and novel sources. To secure result deployment, the project will actively involve middle food system actors (+35,000 companies) – via co-creation and capacity building. For a maximised impact, innovative communication campaigns will be launched in 5 countries, reaching 8 M citizens in 4 years.

Keywords: social innovation,co creation,food environment improvement,consumer empowerment,novel food,living labs,dietary change,vulnerable groups
The macroevolutionay patterns of Mesozoic mammals (Mammal-Dawn)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-05
End date: 2028-01-04
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Since their origination in the Late Triassic, a series of evolutionary innovations throughout the Mesozoic Era resulted in the morphological, physiological, and ecological bauplan for mammals and set the path to their modern success. Due to the incomplete nature and limited access to 3D data for Mesozoic mammal specimens, their evolutionary morphology remains unexplored under a quantitative framework, creating a major knowledge gap in vertebrate evolution. This proposal aims to investigate macroevolutionary patterns of early mammals during the Mesozoic using advanced 3D geometric morphometric techniques. It will generate a new dataset covering 30 well-preserved crania and over 180 upper and lower dentition across major clades of Mesozoic mammals, using advanced 3D scanning technologies, including X-ray Computed Tomography, Synchrotron and Neutron Tomography. Cutting-edge landmark-based and landmark-free morphometric methods will be used to quantify shape variation and underlying effects of allometry and ecological traits. These analyses will reveal trends of cranial evolution, testing whether the cranial morphology in Mesozoic mammals evolved gradually or followed a punctuated pattern. It will also reveal shifts of phenotypic integration and modularity across the tooth row, providing insights into the mechanisms that shaped unusual key innovations of heterodonty and dental complexity in mammals and how that related to other changes in skull morphology through the Mesozoic. The proposed research will not only fill a significant knowledge gap in vertebrate evolution but will also equip the applicant with essential skills in quantitative approaches urgently needed in Chinese paleontology, positioning the applicant as a leading independent researcher in this field.

Keywords: mesozoic,mammals,macroevolution,modularity,fossils,cranium,dentition
UNVEILING THE ROLE OF SUMOYLATION AS NOVEL MOLECULAR PATHWAY IN MYELIN BIOLOGY; IMPLICATION IN NEURODEVELOPMENT AND DEMYELINATING PATHOPHYSIOLOGY. (SUMOMyePath)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 2
Project status: SIGNED

SUMOMyePath: a New Pathway to Wrestle Demyelinating diseases. (Re)myelination is the process by which Oligodendrocyte Precursor Cells (OPCs) migrate and differentiate and mature into myelin generating Oligodendrocytes (OLs). Understanding this process is key to cure demyelinating disorders of which, Multiple Sclerosis (MS), is the most prevalent, affecting 2.8 million individuals worldwide and specially women (69%). SUMOylation is a post-translational modification mainly studied in neurons within the central nervous system, however its pathway’s role in oligodendroglia and its relation with myelin (patho)physiology remains to be investigated. Thus, it is an exciting field to explore and SUMOMyePath will address this challenge by synergizing the applicant’s experience in SUMOylation and myelin biology and the expertise of 1) the host group´s (UniTo) in OPCs biology and 2) the secondment group´s (Ubx) in state-of-art live-imaging of OL lineage cells, opening novel avenues of research and, as consequence, new diagnostic and therapeutic strategies.

Keywords: myelin sumoylation oligodendrocites opcs demyelinating diseases multiple sclerosis remyelination sumo pathway sox10
CorrelAtes of Protective immuniTy-driven Investigation of malaria VAccine combinaTion stratEgies (CAPTIVATE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Germany,Czechia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 54.0
Total project cost (EUR): 540000.0
EU funding (EUR): 540000.0
Participants: 2
Project status: CLOSED

Malaria remains a serious health concern worldwide, with P. falciparum considered one of the deadliest human parasites. Yet, the currently approved vaccine against malaria (RTS,S/AS01) offers limited protection due to challenges in vaccine development. Using current advances made in understanding immunity to address some of the existing challenges, this proposal aims to develop a more efficacious vaccine against P. falciparum by targeting multiple developmentalstages(sporozoite, liver and blood-stage). In this project, combinations of 1) highly promising whole parasite vaccination approach targeting the liver (late-arresting GAP), 2) RTS,S (provided by GSK) and 3) mRNA versions of clinically evaluated and partially protective blood stage vaccine candidates (Rh5, AMA1-DiCo [sporozoite and blood stage]) will be evaluated in preclinical and small-scale human trials to discern the optimal combination for further clinical investigations. To inform a rational design of future vaccine candidates, CAPTIVATE will analyse the vaccine-induced immune response to acquire a full understanding of malaria protective immunity and develop an advanced immunology in-silico platform. While immunity to blood stage malaria is relatively well understood, the mechanisms of adaptive protective immunity for pre-erythrocytic malaria vaccine candidates are less well-established. CAPTIVATE addresses this critical knowledge gap by combining state-of-the-art preclinical and clinical (CHMI) in vivo malaria vaccine efficacy models with an innovative in-silico platform comprising TCR/VDJ sequencing and artificial intelligence predictions, to identify such mechanisms. CAPTIVATE assembles a unique combination of European experts in their respective fields (malaria modelling in primates, clinical vaccine testing, in-silico modelling of immune responses, innovative omics approaches) in an integrated interdisciplinary approach aimed at bringing the next generation malaria vaccines to the clinic.
Development of next generation pathways leading to just energy transition and industrial deep decarbonization (PARADISE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,Spain,Hungary,Poland,Sweden,Netherlands,Pakistan,Malaysia,China,Norway,Czechia
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2024-12-01
End date: 2028-11-30
Duration (months): 48.0
Total project cost (EUR): 557914.29
EU funding (EUR): 538200.0
Participants: 15
Project status: SIGNED

Foundation industries (cement, steel, glass, ammonia etc) are classified as hard-to-abate sectors due to the inherent high-temperature processes. Decarbonization of industry is technically possible through a combination of technical solutions, the optimum mix of which will vary widely between sectors and regions. Deep decarbonization technologies such as application of alternative carbon neutral fuels and carbon capture are essential to achieve the target of net zero by 2050 in the EU. The project aims to evaluate, develop and demonstrate the advanced and emerging technologies for sustainable energy transition and industrial deep decarbonization. Firstly, the project attempts to remove the barrier associated with high operational and infrastructure costs incurred by the traditional carbon capture and storage (CCS) technology applying aqueous scrubbing. The project also evaluates and justifies the potential of a negative CO2 emission solution by combining CCUS with biomass derived carbon neutral fuels (BECCS). In addition, the project aims to conduct a comprehensive feasibility study on the application of ammonia in selected industrial processes as an alternative carbon neutral fuel to replace fossil fuels. The project attempts to apply a wide range of research methods at different scales from microscopic material design to laboratory scale testing and pilot scale trials, and finally to industrial scale deployments supported by the industrial partners. Multi-scale modellings such as reaction kinetics modelling, CFD modelling and process modelling will be performed for system optimization. Techno-Economic Analysis and Life Cycle Assessment on carbon footprint of the full supply chain will be conducted for all three above-mentioned decarbonization pathways. Additionally, Artificial Intelligence (AI) driven approach will be used to predict the dynamic CO2 emissions from industrial sites under scenarios using different combinations of renewable fuels with CCUS.

Keywords: industrial decarbonization ccus bioenergy ammonia cfd modelling tea lca ai modelling
Superconducting and ferroelectric two-dimensional electron gases (2DEGs) at oxide interfaces. (SURFER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

In the project “SURFER”, we will demonstrate the coexistence of antagonistic properties namely superconductivity (SC) and ferroelectricity (FE)” and the enhancement of superconducting transition temperature (TC) through coupling with FE in oxide two-dimensional electron gases (2DEGs). So far, this coupling has almost only been observed in bulk oxides and in thin films of doped SrTiO3 (STO) where no ferroelectric switching is possible due to the three-dimensional distribution of carriers. The origin of SC and enhanced TC due to coupling between FE and SC is still not clarified, which might be because only one material (STO) system has been studied. In SURFER, we aim to realize ferroelectric and superconducting oxide 2DEGs with enhanced superconducting properties that are also switchable with FE present in these systems. With this aim, we will explore three new oxide 2DEG systems that have not been studied so far which will be fabricated based on different ferroelectric materials (1. STO thin films. 2. BaTiO3, and 3. Niobium (Nb)-substituted KTaO3) by growing on top a thin metal or oxide overlayer. In addition to the experimental realization of oxide 2DEGs hosting such interesting properties, this project will also help us to gain a clear understanding about the origin of SC and enhanced TC, due to FE and SC coupling in oxides which is a longstanding question by investigating the properties of these material systems in detail.

Keywords: oxide 2degs,ferroelectricity,superconductivity,coexistence of ferroelectricity and superconductivity,thin films
Magnetically Tunable Chondrocyte Cell Sheet Engineering for Osteoarthritis Therapy (MACROS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2025-08-31
Duration (months): 30.0
Total project cost (EUR): 217309.2
EU funding (EUR): 217309.2
Participants: 2
Project status: SIGNED

Osteoarthritis (OA) is a disease that gradually degrades the cartilage joints, affecting more than 50 million people in Europe. With no known treatment, this population is at risk of lower quality of life and permanent disability. The chondrocyte is a native cell in the cartilage joints that has been studied as a promising cell therapy agent for early-stage OA. Recently, by using a stimuli-responsive (SR) culture plate, many cell types can be prepared as a sheet-like cluster (cell sheet) analogous to the native biological tissue, entailing the enhanced regenerative efficacy when used as cell therapy. However, it is challenging to prepare the chondrocyte cell sheet, as the chondrocyte gradually loses the cartilage feature upon being cultured on the stiff SR plate. In this project, I aim to prepare the cartilage-like chondrocyte cell sheet by developing an innovative technique that is premised on the tuning of substrate stiffness during the cell culture stage. I will focus on three objectives: (1) to develop a new cell sheet-fabrication substrate that has the magnetically tunable stiffness, (2) to study the proof-of-concept of the tunable stiffness technique for modifying the model cell sheet activities, and (3) to apply this dynamic technique to obtain the cartilage-like chondrocyte cell sheet of which its regenerative efficacy against early-stage OA will be evaluated. To perform this project, I will draw from and extend upon my current expertise and works in biomaterial development and stiffness-cell interaction, with that of academic host Prof. Berensmeier (magnetic nanotechnology) and of industrial partner Dr. Vonk (cartilage cell therapy). This synergized academic-industry partnership will continue to the non-academic placement, wherein I will undertake the next-stage preclinical developments of chondrocyte cell sheets in a deeper and more relevant context of OA treatment. The proposed project gives a great contribution to the OA-stricken European society.

Keywords: magnetic responsive hydrogels,magnetic nanoparticles,supramolecular hydrogel,ureidopyrimidinone,tunable stiffness,articular cartilage,chondrocyte cell,cell sheet,cell therapy,osteoarthritis