Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Exploiting fundamental insights of m6A methylation on CD8 T cell differentiation and function to boost medicinal T cell products (M6ATCELL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-01
End date: 2025-09-30
Duration (months): 30.0
Total project cost (EUR): 234530.4
EU funding (EUR): 234530.4
Participants: 2
Project status: CLOSED

Adoptive T cell therapies have revolutionised cancer treatment in some haematological tumours. Despite astounding advances, patients often relapse because the transferred T cells have low persistence and they lose their effector function against cancer cells. The prime challenge for improving T cell therapies is to decipher the mechanisms that define T cell effector function and memory formation. The MA6TCELL project aims to disentangle this problem by defining how m6A methylation on mRNA regulates human CD8 T cell differentiation and function. m6A is the most abundant mRNA methylation and determines gene expression by regulating mRNA metabolism, altering as such cell function. Using the miCLIP assay, I previously mapped genome-wide the m6A sites on the mRNAs of human CD8 T cells (unpublished data I will provide the host with). This map revealed that m6A occurs not only at the known DRACH sequences, but also at AU-rich sequences (AREs). Intriguingly, the host has uncovered that AREs are critical regulators of cytokine production in memory CD8 T cells (host expertise). My pilot experiments revealed that chemical inhibition of a m6A demethylase in CD8 T cells decreased cytokine production, further supporting my hypothesis that m6A methylation controls CD8 T cell differentiation and function. To test this hypothesis the M6ATCELL project will: 1) define the regulatory mechanisms of m6A methylation in human CD8 T cell differentiation and effector function and 2) test whether m6A enzyme inhibitors improve the potency of CD8 T cell therapies using chimeric antigen receptor (CAR) T cells. Our findings will yield fundamental insights in T cell biology, which can be relevant for multiple adoptive T cell therapies. My long-term aim is to transfer my scientific findings from bench-to-bedside. Thus, I also secured a placement at the European Medicines Agency and if this proposal is granted, I will be trained on the regulatory guidelines of medicinal T cell products.

Keywords: cd8 t cells,m6a mrna methylation,t cell differentiation and function,post transcriptional regulation,adaptive immunity,cancer immunotherapy
Novel recuperation system to maximize exergy from anergy for fuel cell powered geared electric aircraft propulsion system. (exFan)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Countries involved: Spain,Austria,Germany,Belgium
Call: Accelerating climate-neutral hydrogen-powered/electrified aviation (HORIZON-CL5-2023-D5-01, 2023)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 3984082.5
EU funding (EUR): 3984082.5
Participants: 10
Project status: SIGNED

To achieve climate neutrality in aviation by 2050, hydrogen powered aircraft propulsion can be key. For this, several challenges need to be tackled such as thermal management and heat rejection of fuel cells in the aircraft. For each watt of electricity produced by a fuel cell, one watt of waste heat is generated. Recuperating it to further use would be indeed an asset. The exFan project will target such innovation by including a ducted heat exchanger in the nacelle of the propulsion system. It will use the ram jet effect, called also "Meredith effect" (ME) to generate thrust from waste heat. The design of a lightweight heat exchanger and the recovery of waste heat using the ME are promising topics further investigated in detail here. The exFan system will be included in a geared electric fan propulsion system of mega-watt class powered by hydrogen fuel cell technology. The heat exchanger will be a bionic design duly surface finished to hinder particle accumulation, corrosion, and erosion. Additionally, novel thermal management system will be designed, to optimize the heat quality of the waste heat and control the heat flux of the propulsion system. Optimal operation conditions will also be investigated. A simulation model will be set up for operation parameter optimization. First functional lab scale tests of exFan will serve to verify such model. The breakthrough innovations proposed in exFan will i) allow European aircraft producers to offer savings in cost operation ii) enable European aeronautics industry to maintain global competitiveness and leadership, and iii) create significant contribution in the path towards CO2 and NOX emission free aircrafts. exFan brings together multidisciplinary experts from academia, aeronautical associations and industry, supported by a selected technical advisory board. exFan will be in close contact with Clean Aviation and Clean Hydrogen to create synergies and speed up the development.

Keywords: design,heat rejection,heat recovery,propulsion system,geared electric fan,heat exchanger,fuel cell,thermal management,simulation
Minimal submanifolds in Arbitrary Geometries as Nodal sEts: Towards hIgher Codimension (MAGNETIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1420400.0
EU funding (EUR): 1420400.0
Participants: 1
Project status: SIGNED

The goal of this research proposal is to advance the calculus of variations of area in codimension higher than one, specifically existence and regularity of its critical points (minimal submanifolds) and properties of its gradient flow (mean curvature flow). These are central objects in mathematics since three centuries and contributed to the birth of geometric analysis, geometric measure theory, and calculus of variations. Their (non-)existence often reveals deep links between small-scale geometry (curvature) and large-scale structure (topology). While the hypersurface case is by now well understood, with several deep results in the last two decades, very little is known in codimension at least two, especially for unstable submanifolds not minimizing area. Several projects will focus on the intimate link between area and some well-known physical energies: phase transitions are understood to give diffuse approximations of hypersurfaces, while vortices in models of superconductivity relate to codimension two submanifolds. An energy proposed by me and D. Stern in this context is the abelian Higgs model, which I plan to use to extend the Lagrangian mean curvature flow past singularities and to relate stability and regularity of minimal submanifolds, which are two long-standing questions in geometric analysis (among other projects), by exploiting the much richer structure given by the PDEs solved by critical points of this energy. I will also look at candidates in codimension three and higher, inspired by energies from gauge theory and others of Ginzburg–Landau type, relating stability and minimality in critical dimension and attacking other basic open questions. Finally, I will also work on another set of projects exploiting parametrized varifolds, a variational object pioneered by me and T. Rivière combining advantages of the parametrized and intrinsic viewpoints, to study Lagrangian surfaces and minimal submanifolds of higher dimension

Keywords: minimal surfaces,geometric measure theory,mean curvature flow,abelian higgs model,parametrized varifolds,ginzburg landau
The integration of technology with medical and healthcare education - a leadership program (INSIDE:INSIGHT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,Austria,Germany,Finland,Netherlands,Italy,Canada,New Zealand,Portugal
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 2754628.46
EU funding (EUR): 2642968.8
Participants: 12
Project status: SIGNED

As emerging technologies are transforming the way we approach medical and healthcare education, it is imperative that our trainees are at the forefront of the development of new tools and digital platforms, while simultaneously becoming fluent in these technologies. In the INSIDE:INSIGHT project, we build a training network for young professionals, making them versed in educational technologies, 3D visualisation and collaborative working, while equipping them with a wide range of transferable skills. This is attained by bringing together researchers from biomedical sciences, computer sciences, educational sciences, biomedical engineering, medical technology and bioethics, as well as partners from the industry. The research focuses on the development, implementation and validation of XR-enhanced educational tools for biomedical and health sciences. This is achieved by: 1) Developing evidence-based technology-enhanced learning (TEL) materials and platforms building upon our track record in this domain; 2) Using a theoretical framework to evaluate how the implementation of TEL materials impacts effective learning and knowledge retention, and 3) To identify the elements that are needed to maximize these effects. By integrating disciplines and sectors we go beyond the state-of-the-art and develop evidence-based XR learning environments that are effective, future-proof and tailored to the needs of diverse learners. The project addresses EU's Open Education policy, creating learning materials that are free and accessible to all, at any time. This will facilitate remote learning taking student diversity in all its aspects into account. At the same time, this interdisciplinary and intersectoral network creates diverse, high-level training opportunities for the proposed Doctoral Candidates providing the trainees with a broad range of skills that will empower them to become the leaders of tomorrow.

Keywords: extended reality,immersive learning,open education,technology enhanced learning,biomedical sciences,student diversity
CiSMA: Circular Steel for Mass Market Applications (CISMA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Clean Steel (co-programmed)
Countries involved: Spain,Netherlands,Austria,Sweden,Belgium
Call: CO2-neutral steel production with hydrogen, secondary carbon carriers and electricity OR innovative steel applications for low CO2 emissions (Clean Steel Partnership) (RIA) (HORIZON-CL4-2024-TWIN-TRANSITION-01, 2024)
Start date: 2024-11-01
End date: 2028-04-30
Duration (months): 42.0
Total project cost (EUR): 4380528.5
EU funding (EUR): 4380528.5
Participants: 13
Project status: SIGNED

Scrap-based production of Steel using Electric Arc Furnace (EAF) with possibility of 100 % scrap charges, offers a Circular Economy-based solution to reduce CO2 emissions when compared to the integrated Blast Furnace (BF) + Basic Oxygen Furnace (BOF) route (1.81 tCO2/tsteel for BOF vs 0.23tCO2/tsteel for EAF). However, EAF production of sheet steel is currently not a reality due to the effect of undesired residual elements in the scrap. The aim of CiSMA is to introduce scrap-based EAF steel products into mass-market sheet metal consumer goods with high-quality requirements, currently served with BOF steel (96 % of the market). First, by generating fundamental knowledge on how residual elements, and Copper in particular, interact with sheet Steel and its performance. This will be done combining state-of-the-art methodologies with specialized resources, such as Synchrotron, to design Steel grades and determine safe residual thresholds. Next, scrap as a raw material will be studied together with methodologies to improve its quality and maximize the use of low-quality scrap, through the use of techniques that separate undesired inclusions from the main stream of steel. Finally, by generating a toolbox of enabling technologies to introduce recycled sheet metal in the industry: 1) fast characterization tests for quality control, 2) online test methodologies that can be applied in the press floor, and 3) the development of Machine Learning-enhanced Finite Element Modelling and Digital Twin that allow adapting production processes to feedstock with high variability. These developments will be showcased in applying four steel compositions into two pilot trials for mass-market applications: automotive and white goods. These trials will ensure that the material and production route developed can be readily accepted by the market, demonstrate the developed toolset of enabling technologies, and quantify the environmental improvements achieved compare to the current product.

Keywords: appliances,automotive,circular economy,copper,electric arc furnace,machine learning,manufacturing,metallurgy,modelling,recycling,scrap,sheet metal,steel,synchrotron,advanced testing
European Men, Masculinity, and Extremist Leadership Online (EMMELO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Ireland,France,Austria,Sweden,Slovakia,Germany,United Kingdom
Call: Gender-roles in extremist movements and their impact on democracy (HORIZON-CL2-2024-DEMOCRACY-01, 2024)
Start date: 2025-05-01
End date: 2028-04-30
Duration (months): 36.0
Total project cost (EUR): 2615527.5
EU funding (EUR): 2615527.5
Participants: 8
Project status: SIGNED

The EMMELO Project: European Men, Masculinity, and Extremist Leadership Online examines the role of masculinity in extremist movements online across Europe and the threats it poses to democracy, fundamental rights and EU values. As is well established, the internet has become a focal point for modern extremist activities. What is less understood in a European context is the role masculinity plays in these online communities and platforms. More insight is also required into how extremist leaders use and perform masculinity to appeal to European men, and how, in turn, these men respond to these gender narratives and how this shapes their perception of democracy and the EU. To address this need for deeper, more critical understandings of these gendered phenomena, EMMELO focuses on six countries: Ireland, Sweden, France, Hungary, Germany and Slovakia, exploring how different forms of masculinity are used by extremist movements and their leadership to appeal to men and undermine traditional democratic participation and discourse in cross European contexts. The project explores how extremist movements construct, perform and circulate narratives of masculinity online, how these narratives shape the perspectives and gendered experiences of European men currently or formerly active in extremist online communities, and the wider implications of these trends for democratic processes and social cohesion, online and offline. From its activities, EMMELO will develop innovative, gender-sensitive tools and policy recommendations to enable policymakers, practitioners and citizens better understand and address the role of masculinity in modern European extremist movements. The project's findings will be targeted at key audiences in formats designed to raise awareness at the levels of policy, practice and citizen of the key role masculinity plays in extremism, including how to identify it, discuss it, and challenge it.

Keywords: masculinities,leadership,online spaces,extremism
AI in Courts: Judicial Values in the Age of AI (AI-COURTS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 216240.0
EU funding (EUR): 216240.0
Participants: 1
Project status: SIGNED

While predictive and generative Artificial Intelligence (AI) technologies promise to increase efficiency and accuracy in judicial decision-making, few have holistically questioned their impact on the judiciary and justice system. Widespread adoption of AI tools to assist - or even replace - judges, poses significant challenges to the values of open justice, transparency, accountability, and equality before the law. This project aims to expand the knowledge of judicial use of AI tools and their interaction with core judicial values in the EU; provide a new framework for tackling novel emerging harms from the use of AI technologies in courts, and extend EU’s legal capacity in empirical mixed methods research. Drawing on interdisciplinary theories of judicial decision-making and critical AI studies, mixed method design and comparative EU, UK and US experiences, the project combines comparative doctrinal analysis with expert interviews with judges, lawyers, policy-makers. Project impact will be secured via academic publications, conference presentations, public communication via social and traditional media, expert workshops. Intended outcomes include a normative framework for the future development of public law in EU to govern the use of AI technologies in the courtrooms, thereby placing EU research at the forefront of a novel field of study, contributing to the EU AI strategy and UN SDGs, and promoting EU leadership in a fast-moving area of social and legal change, increasing equality, offering reduced risk and long-term economic and social benefits.

Keywords: artificial intelligence,law,courts,judiciary,automated decision making,genai,law and technology
Deep Ultraviolet Laser For Quantum Technology (UVQuanT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Finland,Lithuania,Sweden
Call: Basic Science for Quantum Technologies (RIA) (HORIZON-CL4-2021-DIGITAL-EMERGING-02, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 2988332.5
EU funding (EUR): 2988332.25
Participants: 8
Project status: SIGNED

Lasers are the heart of today’s quantum science and technology. Since their first invention they have been a flourishing research area and in a few decades have found application in an enormous variety of fields, eventually populating many aspects of our everyday life, also outside of the research laboratory. Since the beginning, there has been a natural push towards extending the accessible frequency range of coherent radiation, eventually covering the whole infrared (IR), visible (VIS), and ultraviolet (UV) spectrum. The large energy and momenta of UV photons offers enormous potential for novel applications. However, for the same reason, deep technological challenges remain before they can be used effectively in science and technology. UVQuanT will tackle this challenge by developing the necessary industrial and scientific expertise to realise new-era, cost-effective lasers and laser optics for the UV and DUV region, positioning the EU as the front-runner in this technology. UVQuanT will focus on new ways of increasing the production of coherent radiation in the UV and DUV region, developing and testing lower cost, more rugged and practical solutions, and will test these novel systems in a range of experiments targeting quantum technology applications. Combining the talent and expertise of industrial and academic partners, UVQuanT will build strong relationships for establishing a path for next-generation quantum technologies.

Keywords: photonics,laser technology,atomic clocks,quantum sensors,ultracold atoms,ultracold molecules,spectroscopy
Design and evaluation of technological support tools to empower stakeholders in digital education (EMPOWER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Spain,Netherlands,Romania,Norway,Belgium,Portugal
Call: Integration of emerging new technologies into education and training (HORIZON-CL2-2021-TRANSFORMATIONS-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 3629488.75
EU funding (EUR): 3629488.75
Participants: 9
Project status: SIGNED

Given technological developments in other domains and lessons from the pandemic, there is a strong push to invest in technology-augmented education. However, much remains unknown; for example, what technological abilities are useful in education, how they can be deployed, what training needs arise, and what shape future policies governing this should take. EMPOWER contributes to resolving these questions by developing novel technological support for the education of children with neurodevelopmental disorders (NDDs). This use case is, in many ways challenging, and thus ideally suited to 1) make a positive impact on the educational needs of these children, and 2) highlight the potential and limitations of technology-augmented education in a way that can inform future developments generally. NDDs affect approximately 15% of children aged 3 to 17 years. These children can experience difficulties with language and speech, motor skills, behaviour, memory, learning, or other neurological functions and benefit from education tailored to their needs. EMPOWER creates a novel platform based on new paradigms from psychology that suggest that Executive Function (EF) and Emotional Self Regulation are two key sets of skills to target in the educational intervention for these students. The core output of EMPOWER is thus an educational platform, co-created by all involved stakeholders, that facilitates the improvement of these key skills in children with NDDs. The platform will be tested and evaluated in school settings with all stakeholders involved according to the strict standards of a randomized clinical trial. In addition to technological advances, the lessons learned from the development and deployment of this platform will provide valuable insights into the needs and possibilities for training teachers in the use of new technologies as well as input into future policies governing technology in education, including, in particular refined ethical frameworks.

Keywords: neurodevelopmental disorders,enhanced pedagogies,artificial intelligence,eye tracking,biosensors,ethics and education