Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Creation of a group of Excellence on Engineered Biofilms (e.Biofilm)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Portugal,United States
Call: ERA Chairs (HORIZON-WIDERA-2022-TALENTS-01, 2022)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 2498245.0
EU funding (EUR): 2498245.0
Participants: 2
Project status: SIGNED

Biofilms are complex and dynamic structures of interface-associated microbial cells, enclosed in a matrix of extracellular polymeric substances. They are ubiquitous both in nature and human-built environments, greatly affecting the progression of clinical infections, environmental sustainability, and industrial processes. The complexity of these structures renders the apparently simple goal of engineering and growing reproducible biofilms as an elusive task. The main objective of this proposal is to set-up a Group of Excellence on engineered Biofilms (e.BIOFILM) at the Faculty of Engineering of the University of Porto (UPorto). e.BIOFILM will build upon the expertise and network of experts from the prospective ERA Chair holder Darla Goeres and her current employee, the Center for Biofilm Engineering of Montana State University (MSU), the most well-established centre in biofilm research in the world. In addition to research excellence in engineered biofilms, e.BIOFILM will include a thriving educational and training program, a technology transfer program that promotes innovation, and adequate communication and dissemination strategies that establishes links with the scientific community, industry, regulatory entities and the public in general in the European Research Area.

Keywords: engineered biofilms,biofilms reproducibility,biofilm reactors,biofilm analysis,biofilm modelling
Long-Term Joint EU-AU Research and Innovation Partnership on Sustainable Energy (LEAP-SE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: COFUND actions
Countries involved: France,Algeria,South Africa,Romania,Austria,Italy,Belgium,Germany,Portugal,Türkiye,Morocco,Cameroon,Senegal,Egypt,Namibia,Tunisia
Call: Africa-EU CO-FUND action (HORIZON-CL5-2024-D3-01, 2024)
Start date: 2024-10-01
End date: 2030-09-30
Duration (months): 72.0
Total project cost (EUR): 29495738.08
EU funding (EUR): 9999999.97
Participants: 23
Project status: SIGNED

Built on LEAP-RE programme implemented between 2020 and 2025, the LEAP-SE action will organize 2 co-funded calls steered by European and African funding organisations. The Calls Steering Committee (CSC), gathering all funding organisations involved in the action, will select the projects to be funded considering the specific national eligibility and funding rules of each funding agency (nationality of beneficiaries, TRL, nature of beneficiaries, thematic scope, etc.). It should be noted that, even if the overall scope of LEAP-SE enlarges to all sustainable energy fields matching the CCSE scope on energy (including the multiannual roadmaps of LEAP-RE and the enlarged to green hydrogen issues) it will still be possible for funding agencies to focus their specific action on their own priority lines, in term of thematic focus or on TRL level. LEAP-SE draws on the experience and partnership developed in LEAP-RE. This partnership is further strengthened by a much larger number of African organisations/countries participating to the co-funded calls and by previous collaboration between partners in other projects supporting the EU-Africa HLPD on STI, such as LEAP-Agri, ERAfrica, LEAP4FNSSA, RINEA, CAAST-Net Plus and FOSC. It will work with other European partnerships such as CETP and DUT. LEAP-SE will also ensure the follow-up and monitoring of the funded projects, the valorisation of the results and clustering activities will ensure a broad dissemination of projects outputs reaching a global coherence among funded projects and avoiding fragmentation. The high-level dialogue foreseen with policymakers and institutional stakeholders will ensure that LEAP-SE has access to the relevant instances to raise any policy or regulatory issue hindering the deployment of some innovative solutions.

Keywords: africa,europe,cofund
Dimensionality of the human phenome (Dimension)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: United Kingdom
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-11-01
End date: 2030-10-31
Duration (months): 60.0
Total project cost (EUR): 2499733.0
EU funding (EUR): 2499733.0
Participants: 1
Project status: SIGNED

What am I going to do? I will use data from millions of human genomes and thousands of traits (the “phenome”) to quantify the dimension of the heritable human phenome and dissect and map it to single DNA variant resolution; use whole genome sequence data in populations and families to estimate mutational trait heritability; predict future phenotypes using millions of DNA variants and thousands of environmental factors. Why am I going to do this? Despite the discovery of hundreds of thousands of DNA variants that are statistically associated with one or more human complex traits, we do not know which variants are causative, how many traits they affect (pleiotropy), how they function and why there is so much genetic trait variation in the first place. We understand even less of how environmental factors (the “exposome”) interact with genomic variation to cause the variation in phenotypes that we observe. What is missing is a full genome-wide characterisation of multivariate genetic architecture and estimates of genetic variation due to new mutations. A better understanding of pleiotropy, mutational variance and the exposome will inform theoretical and biological models of trait variation and improve prediction of disease in personalised medicine. How am I going to do this? This Project will repurpose data from multiple large biobanks containing millions of genotyped and sequenced individuals who are longitudinally measured on thousands of traits. New advanced statistical approaches will be developed, tested and applied in innovative experimental paradigms that utilise both population and pedigree data. Variance component methods will be developed to estimate mutational variance. Bayesian hierarchical mixture models will be developed and applied to fine-map multivariate trait loci and to predict future disease cases. My Team will develop general user-friendly software tools to achieve the Project aims.

Keywords: quantitative genetics pleiotropy mutational heritability personalised medicine
Gender Empowerment through Politics In Classrooms (G-EPIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Belgium,Denmark,Germany,Czechia,Spain,United Kingdom
Call: The impact of inequalities on democracy (HORIZON-CL2-2022-DEMOCRACY-01, 2022)
Start date: 2023-02-01
End date: 2026-01-31
Duration (months): 36.0
Total project cost (EUR): 2294251.25
EU funding (EUR): 2294251.0
Participants: 7
Project status: SIGNED

Ensuring the future of democracy requires empowering all social group to engage, yet the gender gap in political leadership, political ambition and political self-efficacy is the most persistent and most difficult to tackle across Western democracies. The situation when looking across the intersect of gender, social class and ethnicity becomes even more grave. These differences have been shown to begin in the school and classroom dynamics has been cited as the likely socialisation process that leads to these different outcomes. G-EPIC, a multinational consortium of universities and civil society organisations, has been brought together with the aim of fostering social innovation and testing interventions to reduce gender inequality in politics. The 7 partners in 6 countries (Belgium, Czechia, Denmark, Germany, Spain and United Kingdom) will begin by establishing the state of play through classroom observations and reanalysis of existing quantitative data to understand how inequalities in attitudes and dispositions towards political engagement are learnt. G-EPIC will then create experiments in schools and pilot design-based interventions co-developed with civil-society, teachers and students. These experiments and interventions will be rigorously evaluated in comparisons with control groups and will lead to the development of the Gender Empowerment in Classroom intervention that will be disseminated and delivered in schools across Europe creating the possibility for real change and the reduction of the gender gap in political leadership. In addition, G-EPIC will also carry out a holistic evaluation of the national context and the local and European policy framework to design strategies, regulations and policies that are conducive to a more equitable gender political involvement, particularly of girls with a disadvantaged background.

Keywords: political inequality,disadvantaged groups,gender empowerment,school interventions,intersectionality
Sustainable Hydrogen and Aluminothermic Reduction Process for Manganese, its alloys and Critical Raw Materials Production (HAlMan)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Norway,Slovakia,South Africa,Latvia,Greece,Germany,France,Poland,Australia,United Kingdom,Sweden
Call: Innovative solutions for efficient use and enhanced recovery of mineral and metal by-products from processing of raw materials (IA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 8046086.88
EU funding (EUR): 7316151.63
Participants: 18
Project status: SIGNED

Decarbonization of processes, scarcity of raw materials and Europe independence on key resources, valorisation of industrial waste are all key and strong challenges the EU metallurgy industry is facing and will have to deal with in the next decades to remain sustainable while keeping its economic competitiveness. This is particularly true for the manganese (Mn) & Mn ferroalloys industries. HAlMan represents a game changer in the metallurgical industry in view of developing sustainable processes with low carbon footprint, low energy consumption, no solid waste generation, valorisation of secondary raw materials from mining and metallurgical industry. HAlMan will demonstrate at TRL 7 an integrated process to produce Mn metal and Mn alloys from Mn ores and Mn-containing waste by using hydrogen and secondary aluminum (Al) sources as reductants. As metallurgical processes have large share in CO2 emission, decarbonization in metallurgical industry is essential to operate metal production in Europe. The benefits of the HAlMan innovative process will go beyond Mn and Mn Ferroalloys industries, and it presents a unique intersectoral approach in circular economy where: • Al-containing dross/scrap, and waste from ferromanganese industry are valorised to produce directly new Al-Mn master alloys for Al and Steel industries • metallurgical grade alumina (the feedstock for Al production, produced almost exclusively from Bauxite which is a CRM for EU) is produced via a zero-carbon footprint process • the extraction of critical raw materials, including REEs, from the alumina production process by-products will be demonstrated • the production of manganese oxide and cell fabrication for lithium-ion battery applications will be demonstrated. Additionally, HAlMan project studies heat and hydrogen recovery from process gas to improve process economy and yield. Significant activities on Life cycle assessment, Business development, dissemination and communication will be carried.

Keywords: manganese,hydrogen,manganese metal,manganese ferroalloys,aluminium dross,aluminum scrap,slag,alumina,critical raw materials,aare earth elements,battery materials,manganese steels,cement
Unveiling human astrocyte states, functions and their contribution to Alzheimer´s disease (hASTROCURE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1999875.0
EU funding (EUR): 1999875.0
Participants: 1
Project status: SIGNED

The pathogenesis of Alzheimer´s disease (AD) is not fully understood and no cure is available so far. Current therapeutic targets are insufficient and there is an urgent need for finding new pathways and mechanisms and novel targets to treat this terrible disease. Due to critical species-specific differences and the limitations of rodent models of AD, humanized models are necessary to capture the complexity of the disease process. My lab has pioneered the use of humanized chimeric mice to study human astrocytes (h-astrocytes), integral components of the brain and understudied in AD. I propose here to investigate with a multidisciplinary approach their contribution to AD development and progression. We have already showed the potential of chimeric mice to identify novel and unexpected contributions of h-astrocytes to AD pathology. hASTROCURE will take advantage of our unique model to drive breakthrough discoveries in our understanding of h-astrocytes and their role in AD. We will investigate in humanized chimeras what is the impact of the genetic make-up (risk vs protective variants in AD risk genes) on h-astrocytes molecular states and functions as disease evolves and how they contribute to pathological features and AD progression. The overarching aim is to dissect central pathways leading to h-astrocyte activation towards detrimental states and target those pathways, which can provide the necessary knowledge to enable the development of novel astrocyte-specific therapeutic strategies. This pioneering project involves a set of innovative approaches as an essential platform for studying human genetics in h-astrocytes, in an AD relevant context. My experience and the work that my lab has developed these last years support the conceptual basis of the proposal and demonstrate its feasibility. hASTROCURE will go beyond the state-of-the-art providing groundbreaking information about h-astrocytes and their contribution to AD, and will help to define new strategies for AD.

Keywords: alzheimer s disease,human astrocytes,humanized chimeric models,human pluripotent stem cells hipscs
Easy way to accelerate the scale-up of innovative soft devices for Drug Discovery pipeline (Easy SOFT)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: France
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-07-01
End date: 2023-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Cell&Soft is a Deeptech company based in France (AURA region) which aims to develop, produce and sale innovative solutions for in vitro cell culture, in the field of oncology and stem cell research. Pain point: Drug development process is very expensive, complex and suffers from many failures. In oncology, the average success rate is less than 4%. More than 80% of drug candidates fail in early clinical phases and this after 5 to 7 years of research. Thus, the efforts mobilized consume considerable human and financial resources, without result. Opportunities: One of the most important challenges is the lack of reliable, reproducible, and easy-to-use in vitro models, allowing better predictability and/or reliable diagnosis. Ambition: At Cell&Soft, our ambition is to re-invent in vitro cell culture, by developing innovative devices that act as steppingstones for tomorrow's drug candidates. The objective of Cell&Soft is to accelerate the discovery of new drugs with an average success rate of more than 20%, while limiting the use of animal models. Easy SOFT project: The Women TechEU program is a great opportunity to achieve our ambition by accelerating the growth of Cell&Soft. The Easy SOFT project must allow us to (1) consolidate our added value by strengthening our POCs and IP financing, (2) prepare strategic and operational commercial deployments, and (3) allow a scale up to a pre-industrial stage to meet the Pharma companies at the international level. Women empowerment: As a women scientist and CEO, I want to promote the integration of women in science and in leadership roles. I think I can challenge the status quo to create an environment where women can achieve their potential. Through the Women Leadership Program I want to deploy myself as a female mentor and gain access to new networks within the European innovation ecosystem.
System approach to close the employment gap and create a more inclusive labor market for vulnerable groups (SYNCLUSIVE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Netherlands,Bulgaria,Finland,Portugal,Italy,Ireland,Estonia
Call: Overcoming discrimination for an inclusive labour market (HORIZON-CL2-2022-TRANSFORMATIONS-01, 2022)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 2998752.5
EU funding (EUR): 2998752.5
Participants: 16
Project status: SIGNED

SYNCLUSIVE is an innovative, integral, and interdisciplinary systems’ approach to stimulate inclusion of vulnerable groups in the labor market. To achieve this, our six central objectives are: 1) developing and consolidating a coalition of stakeholders in 4 regional Living Labs across Europe along the lines of the Community Coalition Action Theory, using the ENGINE approach. This approach includes an integrated package of interventions that stimulates upward and sideward mobility of vulnerable employees, hereby creating vacancies for inflow of vulnerable job seekers; 2) testing the usefulness and applicability of the ENGINE approach for different vulnerable groups identified as being discriminated against; 3) identifying drivers and barriers for mobility and inflow including discrimination; 4) assessing the impact of the implemented ENGINE approach on the labor market mobility and inclusion of vulnerable groups; 5) identifying transition pathways from the regional to the national and EU policy level; and 6) identifying interoperable and comparative indicators and standards that are relevant for the labor market inclusion of vulnerable groups taking into account the regional, national (legislative, social security) and cultural context. Regional stakeholder commitment as well as the interdisciplinary collaboration is crucial for the success of SYNCLUSIVE and for inclusion of vulnerable people in the labor market. SYNCLUSIVE therefore collaborates in an ‘active community coalition’ amongst municipalities, employers, civil society and educational institutes, which interacts with their political counterparts at national and EU level across 7 European regions. SYNCLUSIVE results will lead to sustainable inclusion of vulnerable groups in the regional Living Labs, and have vast potential to result in outcomes far beyond the scope and duration of the project. SYNCLUSIVE will contribute to generic and context-specific EU-wide policy and intervention recommendations that drive inclusion of vulnerable groups and help to start overcoming discrimination in the EU labour market.

Keywords: interdisciplinary systems approach,upward mobility,inclusion,professional development,transition pathways
Metasurface Enhanced Near Field THz Sensing of Virions (VIRUSong-Hop)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: France,Türkiye
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 40.0
Total project cost (EUR): 595750.0
EU funding (EUR): 595750.0
Participants: 2
Project status: SIGNED

The ambitious goal undertaken in the already running VIRUSong project is to “listen” to the low frequency acoustic vibrations of a viral particle as a whole object using inelastic light scattering tools such as Raman and Brillouin spectroscopy, either spontaneous or stimulated. In-line with this strategy VIRUSong-Hop project’s goal is to develop a THz technology that can measure the vibration of matter at the nanometric scale to detect and identify a viral particle in a few minutes. Bio-sensing of nanometre sized particles with high specificity is not natural in the large-wavelength (> 30 mm) THz region. To accomplish this feat the VIRUSong-Hop effort aims to develop a near-field THz probe time-resolved detection technique that will listen to the acoustic vibrations that oscillate on the order of ps to ns specific to the virus shape and size. This will offer an additional strategy towards the detection and identification of viral particles that will strengthen the existing VirusSong project. The novelty in the technique that allows THz waves to sense these low frequency vibrations (< 600 GHz) is due to the “dark” modes in metasurface structures which can only be accessed in near-field excitation geometries. Called Bound in Continuum modes (BICs) these low-frequency resonances acting like THz light resonators offer the opportunity for prolonged interaction allowing for sensing changes in the presence of different viral particles which are exhibiting vibrations. The development of metasurfaces with extremely high Q-factor symmetry protected BIC modes will allow for the detection of vibrationally stimulated virions whose sizes range from ~10s to 103 nm. The advancements gained through VIRUSong together with VIRUSong-HOP will be the blueprint which guides the development of these novel technologies for diagnostic techniques, making an impact in envisioned critical 21st century technologies in Europe and in the Widening country.

Keywords: vibrations,viruses,virions,near field thz sensing,metasurfaces,bound in continuum modes bics,optical biosensing