Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
KETBIO: A novel cluster model to bring KEY ENABLING BIOTECHNOLOGY research closer to markets and society (KETBIO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Coordination and support actions
Countries involved: Germany,Germany,Italy,Germany,Sweden,Poland,Belgium,United Kingdom
Call: Support for enhancing and demonstrating the impact of KET Biotechnology projects (H2020-NMBP-CSA-2017, 2017)
Start date: 2017-10-01
End date: 2020-08-31
Duration (months): 35.0
Total project cost (EUR): 999312.5
EU funding (EUR): 999312.5
Participants: 9
Project status: CLOSED

This KETBIO project aims at establishing a novel cluster model of biotechnology research projects under HORIZON 2020 to enhance and demonstrate the impact and the outreach of EU funded key enabling biotechnology research. All impact of research is reflected in an appropriate up-take of research outputs through business and society at large as well as through integration into technological and societal systems, the here proposed novel clustering model will thus act as a pivot trajectory to achieve a maximum of these goals for the biotechnology: The proposed cluster will strive to further RTD and innovation through networking and alliance forming and through capacity gains of cluster members. The envisaged clustering of projects and linkage to knowledge transfer activities will allow accelerated industrial exploitation of results through partnering and will maximise impact through exploiting synergies in knowledge transfer and communication. Supporting and coordination activities of KETBIO will lead to the set-up of an actively managed cluster-network of projects facilitating sharing of insights, mutual learning, working group exchange, partnering with industry, dissemination of results and exploring of exploitation pathways. To reach these goals, KETBIO will - Actively promote networking and knowledge exchange between research-industry-policy stakeholders - Establish platforms and online working groups for elaboration on RTD and innovation - Facilitate capacity building through training, webinars, including a lecture library - Provide insights, information and interaction through technology review and science intelligence - Enable partnering between research and industry/ policy partners - Explore a multitude of exploitation pathways, including dissemination of results to the specialist public and to larger audiences

Keywords: biotechnology,technology transfer,exploitation
Soundscapes of Trauma: Music, Sound and the Ethics of Witnessing (MUTE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Cyprus,Greece,Greece
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-12-01
End date: 2026-11-30
Duration (months): 60.0
Total project cost (EUR): 1899587.0
EU funding (EUR): 1662495.22
Participants: 4
Project status: SIGNED

MUTE’s main objective is to investigate for the first time empirically and theoretically the use of music and sound in situations of confinement and displacement from the Cold War to contemporary times. It explores their weaponization in light of transnational developments in technologies of terror. At the same time, it carefully attends to how music/sound can become a tool of survival, even in the same setting in which they are weaponized. Also explored are ethical challenges of such research, and of music programmes for prisoners and refugees, highlighting their shortcomings and providing alternative models. MUTE innovates through a theoretical framework that investigates the interlocking of politics, ethics, and aesthetics, focusing on the ethics of sound and ethics of witnessing. Its comparative approach extends to (post)colonial Cyprus, Greece, Serbia, Germany, Soviet Union and contemporary Russia, Iraq, Argentina, Chile, Uruguay and Paraguay. MUTE will critically analyse this complex phenomenon across the disciplines of (ethno)musicology, social anthropology, history, critical theory, human rights law and sound art, since it cannot be fully grasped through the methods of any one alone. The PI’s extensive immersion into all disciplinary components over the last decade, evident in her novel approach, ensures the successful implementation of research objectives. MUTE’s findings and results will transform scientific discourse, changing current perceptions about music’s social function. This historical recovery is important in revisiting and assessing detention-related policies and current definitions of torture. Given recent mass asylum seeking in Europe and the growing number of music research projects with refugees, it will offer the needed ethical, methodological and theoretical foundations for present and future research, ensuring the well-being of participants and researchers, research excellence, and critically nuanced scholarship.

Keywords: musicology,ethnomusicology,trauma studies,sound studies,social anthropology,ethics,witnessing,trauma memory,detention,displacement,acoustic violence,torture,aesthetics,research based art
Detecting changes in essential ecosystem and biodiversity properties – towards a Biosphere Atmosphere Change Index: BACI (BACI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Research and Innovation actions
Countries involved: Austria,Austria,Germany,Italy,Germany,Switzerland,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom
Call: New ideas for Earth-relevant space applications (H2020-EO-2014, 2014)
Start date: 2015-04-01
End date: 2019-03-31
Duration (months): 48.0
Total project cost (EUR): 3322858.75
EU funding (EUR): 2997858.75
Participants: 12
Project status: CLOSED

The alarming rate of biodiversity loss and ecosystem transitions make it clear that new strategies are required to sustain functioning of the coupled ecological-societal system. Existing space data archives and data streams from the ESA Sentinels, offer unprecedented opportunities to provide rapid, high quality indicators necessary for informed management of key ecosystem services. Yet, it remains largely unclear how space and ground-based observations can be optimally integrated to generate products required by end user communities (Secretariat of the Convention on Biological Diversity, 2014). By fusing extensive expertise on optical and radar remote sensing, ground data on ecosystem state and function, “big data” scientists, and active participation of user groups, BACI will advance this integration. BACI will translate space data to new variables (not directly observable from space) that encode ecosystem functional properties and status metrics. This will empower concepts of “essential biodiversity variables”. Advanced machine learning methods will be employed to reveal new and fundamental relationships between space observations and ecosystem status. BACI will incorporate a wide range of original data and downstream data products specifically targeting needs for early-warning systems, including a novel “Biosphere-Atmosphere Change Index”. We will prioritize selected key European and African regions now undergoing massive societal-ecological transformations, offering perspective towards operational assessments. A formal attribution framework will disentangle climate-induced ecosystem changes and socioeconomic/ecological transformation processes. Overall, BACI will advance usage of European space data to monitor relevant vegetation traits, status, and ecosystem functioning. By capitalizing on existing datasets, we will prototype new algorithms to rapidly implement these metrics and thus space-to-ground integration of the new ESA Sentinels.

Keywords: essential biodiversity variables,ecosystem functional properties,new downstream data products,generic index of change,hotspots of change
Interaction between gut-microbiota and the central stress system in cognitive alterations associated with aging. (Microbiota and aging)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Aging drives cognitive impairment and general health demise increasing the susceptibility to neurodegenerative disorders in healthy individuals. It is also associated with changes in the gut-microbiota and a general increase in the secretion of stress hormones, known to have debilitating effects when sustained. The gut-microbiota has recently emerged has a crucial modulator of cognitive abilities and general health. Nonetheless, the causes and consequences of the gut-microbiota changes seen in aging are currently unknown. In this application, we propose to study the importance of the age-associated gut-microbiota changes on brain functions, by swapping the gut-microbiota from aged mice into young mice and vice-versa. This will allow knowing the contribution of the gut-microbiota in the cognitive decline and depressive state associated with aging. Furthermore, we will test if the increase in stress hormones known to occur during aging are upstream of those age-associated microbiota changes, by testing the involvement of the amygdala to the hypothalamus-adrenal axis in this phenomena. This will be achieved by using a chemo-genetic approach to control the activation of each component of this pathway. This project will provide the first description of the functional repercussions of the age-associated changes in the gut-microbiota composition on learning and memory deficits and depression, and possibly elucidate one of the upstream mechanisms responsible. The outcome of this work will pave the way toward the elaboration of probiotic treatments against the detrimental effect of aging.

Keywords: aging,gut microbiota,learning and memory,depression,stress,amygdala,hippocampus,dreadd
Technology transfer between modern algorithmic paradigms (TOTAL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Poland
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2021-09-30
Duration (months): 66.0
Total project cost (EUR): 1417625.0
EU funding (EUR): 1417625.0
Participants: 1
Project status: CLOSED

The two most recognized algorithmic paradigms of dealing with NP-hard problems in theoretical computer science nowadays are approximation algorithms and fixed parameter tractability (FPT). Despite the fact that both fields are by now developed, they have grown mostly on their own. In our opinion the two fields have critical mass allowing for synergy effects to appear when using techniques from one area to obtain results in the other, which is the main theme of the project. Furthermore, practical effectiveness of randomized local search heuristics is a not yet understood phenomenon. We believe that substantial increase of our understanding of superpolynomial running times in recent years should allow for rigorous proofs of parameterized and approximation results obtained by those methods. Based on our experience with parameterized complexity and approximation algorithms we propose three research directions with potential of solving major long-standing open problems in both areas with the following objectives. (a) Transfer from Approximation to FPT: use the PCP theorem to prove lower bounds for exact parameterized algorithms under the Exponential Time Hypothesis and take advantage of extended formulations in FPT branching algorithms. (b) Transfer from FPT to Approximation: utilize parameterized algorithms tools in local-search-based approximation algorithms and explore the potential of proving new inapproximability results based on the Exponential Time Hypothesis. (c) Rigorous Analysis of Practical Heuristics: unravel the practical effectiveness of randomized local search heuristics by proving their parameterized and approximation properties, when given subexponential or even moderately exponential running time. Our objectives lie in the frontier of fixed parameter tractability and approximation areas. Complete resolution of our goals would dramatically change our understanding of both areas, with further consequences in other disciplines within computer science.

Keywords: fixed parameter tractability,approximation algorithms,parameterized algorithms
Enhancing Innovation Management Assessment Capacity of Enterprise Europe Network partners and Innovation Management Capacity of SMEs (EEENIMAC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany
Call: Supporting assessments of 'innovation management capacity' by the Enterprise Europe Network (H2020-IBA-INNOSUP-IMC-2019, 2019)
Start date: 2019-04-02
End date: 2022-01-01
Duration (months): 33.0
Total project cost (EUR): 2199950.0
EU funding (EUR): 2199950.0
Participants: 1
Project status: CLOSED

Small and Medium Sized Enterprises (SMEs) face significant challenges to successfully innovate for sustainable growth. The Enterprise Europe Network (EEN) as a key player in the innovation eco-system is expected to render highly effective innovation management support services to SMEs. SMEs will adopt these innovation management support services to the degree that EEN staff members are well trained in innovation management support. This requires access to, and experience in assessing the SME’s innovation management capabilities in line with the technical standard CEN/TS 16555. Based on the assessment results, tailored action plans are to be developed and implemented in and with the SMEs. A solid understanding of both key success factors in innovation management is essential, and of effectively supporting SMEs of different age, size, industry, country in developing their innovation management capabilities for sustainable growth. Therefore, the EEENIMAC project aims at enabling the EEN to deliver consistently high value innovation management support services and to develop the performance in the regional innovation eco-system. To achieve these objectives, EEN eligible staff members will receive training, coaching, and on-demand support in state-of-the-art innovation management practices for different levels of proficiency. Furthermore, they will gain access to the proven IMP³rove online tools for assessing up to 4,500 SMEs’ innovation management performance in line with CEN TS 16555. In 4 work packages, a tailored, agile and impact-oriented skill development programme for 450 trainees p.a. will be combined with secure access to proven IMP³rove online assessment tools and international benchmarking databases. The training, coaching and on-demand support will be tailored to the trainee’s needs as defined by the trainee, his/her supervisor, and also based on the regions' economic challenges. It will be offered in a variety of highly interactive settings, off- and online.

Keywords: innovation management,assessment,benchmarking,benchmarking database,skill development,innovation eco system
Magma Outgassing During Eruptions and Geothermal Exploration (MODERATE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany,United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-09-01
End date: 2027-03-31
Duration (months): 67.0
Total project cost (EUR): 2821036.0
EU funding (EUR): 2821036.0
Participants: 2
Project status: SIGNED

Magmatism is central to planetary evolution, controlling differentiation, volcanic eruptions and most geothermal systems. The presence of volatiles regulates magma buoyancy, storage and transport. As temperature, pressure and stress evolve – during transport, crystallisation, earthquakes or geothermal exploration – volatiles exsolve and either accumulate or escape magma, influencing the probability and style of an eruption. Understanding the controls on magma-gas coupling is thus fundamental to resolve volcanic activity as well as manipulate its response to drilling operations when harnessing magma energy. This project aims to constrain Magma outgassing during eruptions and geothermal exploration (MODERATE). I propose a timely, innovative, interdisciplinary project to radically broaden our understanding of magma-gas coupling in volcanic and (superhot) geothermal systems. The objectives are to: 1) constrain the impact of external forcing mechanisms (i.e., decompression, temperature changes, shear and pressure oscillations from shaking, impact and rupture) on the kinetics of vesiculation, 2) quantify the development of magma permeability, and 3) define thermo-mechanical strategies to moderate magma outgassing and alleviate the risk of volcanic eruption associated with drilling and borehole operations. A map of magma vesiculation and permeability under a wider range of conditions and stressing scenarios than ever achieved before will allow us to resolve current conundrums and explore new regimes to control permeability in magma. This innovative effort will allow us to moderate magma outgassing, thus enabling direct access to magma energy and eventually providing a means to control outgassing and alleviate eruption potential.
REVOLUTIONARY ELECTROMAGNETIC ENDOSCOPY ACCESSORY TO AUTOMATIZE POLYP DETECTION (MiWEndo)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-10-01
End date: 2023-12-31
Duration (months): 39.0
Total project cost (EUR): 2077043.75
EU funding (EUR): 1453930.63
Participants: 1
Project status: SIGNED

Every year 1,4 million new cases of colorectal cancer (CRC) are diagnosed. Polyps and early-stage CRCs are usually asymptomatic or have symptoms that can be easily confused with other mild ailments. This cancer can be cured in more than 90% of cases if precancerous polyps are detected and removed. Colonoscopy is the most effective method to remove polyps in the entire colon. However, 8% of CRCs are diagnosed after a negative colonoscopy, and 22% of polyps are not detected due to visual limitations of the colonoscope camera. MiWEndo Solutions is a medical device startup focused on bringing innovative technologies to practical diagnosis of diseases related with tumor processes. Its first product is MiWEndo, a low cost and safe electromagnetic device designed to be attached to the tip of a conventional colonoscope. MiWEndo automatizes polyp detection emitting an alarm when a polyp is sensed, increases the field of view to 360º and provides quantitative differentiation between malignant and benign polyps without changing current clinical practice. Its core technology is based on microware imaging, and we have developed algorithms that can differentiate between healthy colon mucosa, cancer, and different histological types of polyps based on their dielectric properties. Our technology is protected with European patent EP3195786A1. After CRC detection, additional applications of our technology will include other bowel disorders. We have a financial need of 3,8 M€ between 2020 and 2023 (product launch). Of these, 1,5 M€ will be provided as a grant from the European Commission within the EIC Accelerator Program (2020-2022), corresponding to 70% of the project budget. At the end of the project MiWEndo will have reached TRL8, including a clinical validation in a clinical trial, and will have obtained CE mark and FDA approval prior to product launch in early markets.

Keywords: endoscopy,microwaves,machine learning,oncology
Integrated Imaging in live Cell Analysis (II-LCA), for enhanced development and manufacturing of biologic and cell therapies. (II-LCA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Ireland
Call: European SME innovation Associate - pilot (H2020-INNOSUP-2019-02, 2019)
Start date: 2019-09-15
End date: 2020-09-14
Duration (months): 12.0
Total project cost (EUR): 123746.25
EU funding (EUR): 123746.25
Participants: 1
Project status: CLOSED

The successful recruitment and incorporation of an Innovation associate (IA), with expertise in live cell imaging, life sciences instrumentation and automation, into the Valitacell team is integral to the evolution of our technologies. The IA will dramatically enhance Valitacells capabilities in this space, strengthen existing collaborations, and generate further opportunities for future innovation. If successful, II-LCA will lead to the accelerated development of novel biological drugs and cellular therapeutics, for the treatment of diverse disease indications. European patients will benefit from increased access to targeted and innovative breakthrough therapies, through reduced cost of development and improved manufacturing paradigms.

Keywords: live cell imaging,cell line development,biologic drugs,cell therapy,cell manufacturing,automation