Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The role of magnetism in the search of radiation-resistant materials for fusion reactors (MaDRAS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-06-01
End date: 2028-05-31
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: SIGNED

Nuclear fusion reactors require materials capable of enduring extreme radiation levels, posing a significant challenge in materials science. Radiaton-induced defects such as vacancies, interstitials, and dislocations critically influence the mechanical and thermal properties of these materials, and their behavior is strongly affected by the material’s magnetic state. Understanding the interplay between magnetism and defect properties is essential for advancing nuclear material development and designing materials with superior mechanical and radiation performance. Spin-Lattice Dynamics (SLD) simulations, which couple atomic and magnetic degrees of freedom, provide an optimal framework and a powerful tool to explore these interactions at the atomistic level. The MaDRAS project aims to investigate the interconnections between defects and magnetic properties in nuclear materials through SLD simulations. By focusing on the role of magnetism in defect behavior in two candidate materials for fusion reactor, FeCr alloys and FeCrNiMn high entropy alloys, the project seeks to identify mechanisms that contribute to the development of materials with better performance for nuclear applications. The primary goals are to establish a computational framework for assessing both the role of magnetic excitations in radiation-induced defects in nuclear materials and the influence of such defects on magnetic properties. The successful completion of this project will not only contribute to the fundamental understanding of magnetism’s role in defect production and mobility but could also drive significant innovations in the design of materials for fusion reactors and other advanced nuclear technologies.

Keywords: material science nuclear materials radiation damage defects magnetism spin lattice dynamics simulations
Timing the evolution of the dissimilatory sulfur cycle: a bridge between genes and geochemistry (DatingSuCy)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 183600.96
EU funding (EUR): 183600.96
Participants: 1
Project status: CLOSED

Earth's biogeochemical sulfur cycle is driven by various microbial dissimilatory processes that couple sulfur redox transformations with energy conservation. These dissimilatory sulfur metabolisms are catalysed by a linked suite of "enzymatic machineries" composed largely of multimeric protein complexes. Over geological timescales, the sulfur-cycling "machineries" have co-opted to create a dissimilatory metabolic network at planetary scale, which has had tremendous consequences on the Earth’s major biogeochemical cycles, surface redox states and climate stability. The advent and expansion of sulfur-cycling "machineries" thus represent milestones in the multibillion-year history of Earth and life. Yet, the timing of the onset of diverse dissimilatory sulfur metabolisms and their interplay with sulfur geochemistry remain generally unconstrained due to the rarity of microbial fossils and ambiguity of ancient stable isotope signatures. The research proposed herein will explore the origin and evolution of dissimilatory sulfur metabolisms by leveraging genomes of uncultivated bacteria and archaea from metagenomes, advances in molecular clock and quantitative evolutionary models, and extensive compilations of sedimentary sulfur isotope records. A novel combination of large-scale comparative phylogenetic analyses and geochemical data will (1) derive expanded phylogenies for a comprehensive set of genes encoding full repertoires of dissimilatory metabolisms of inorganic and organic sulfur compounds, including uncharted sequences from new genomes; (2) map the evolutionary history of sulfur-cycling genes onto a geological timeline; and (3) formulate testable hypotheses on feedbacks between historical shifts in sulfur geochemistry and metabolic innovations. The aim of this work is to create the first unified timescale for the evolution of dissimilatory sulfur metabolisms and geochemistry, and document the transitions of early Earth’s sulfur cycle towards its modern complexity.

Keywords: evolution dissimilatory sulfur metabolism bacteria archaea biogeochemical cycle sulfur isotope geochemistry
A synaptic mechanogenetic technology to repair brain connectivity – Hop-on widening with human in vitro models. (SynMech Hop-on)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Italy,Hungary
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 48.0
Total project cost (EUR): 545462.5
EU funding (EUR): 545462.5
Participants: 2
Project status: SIGNED

The SynMech project is developing a mechanogenetic technology to regulate functional connectivity of neural circuits for therapeutic purposes in brain disorders. The objective of SynMech-Hop on is to complement the original work plan with i) novel, highly translational human 2D and 3D in vitro models of epileptic seizures, ii) increase the human translational value and reduce animal use (3Rs), and iii) enhance the project innovation capacity via higher TRL levels towards clinical applicability, business development, regulatory, societal acceptance and industrial key stakeholder communications. Our ambition is to use in vitro neural models derived from human induced pluripotent stem cells (hiPSCs) to evaluate biosafety and efficacy for epilepsy of synaptic mechanogenetics. BIOT provides a wide variety of human in vitro methodologies, which could complement the excellence of SynMech technologies by generating standardized in vitro human epilepsy models with the use of patient-derived iPSCs and epileptic seizure-inducing drugs, and thus fill current scientific gaps. Induced seizures can be used to effectively address human in vitro seizure-liability testing because they allow us to define both electrogenic and non-electrogenic aspects of epilepsy in a spatiotemporal fashion, enabling the assessment of the efficacy and biocompatibility of SynMech technology components (functionalized biocompatible magnetic nanoparticles, bioengineered synaptic mechanosensors and magnetic stimulators). We will assess efficacy and safety of synaptic mechanogenetics as an antiepileptic treatment in human 2D and 3D in vitro models, comparing it to established pharmacological anticonvulsant approaches. This will allow SynMech partners to add an additional layer of interdisciplinarity and integrate BIOT’s in vitro solutions to replace some animal experiments (3Rs) and to enhance industrial and medical translatability, underpinning SynMech’s innovations towards higher TRLs.

Keywords: human ipsc,in vitro 2d and 3d neural models,epilepsy in vitro models,neurotoxicity,pre clinical models
Thermalization at High Energies (High-TheQ)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 1950000.0
EU funding (EUR): 1950000.0
Participants: 1
Project status: SIGNED

Thermalization of closed quantum systems is central to the modern understanding of matter, from ultracold to ultrahot. High-TheQ studies thermalization of quantum fields excited by nuclear collisions at RHIC and LHC to energy densities equivalent to trillions of Kelvins. In such extreme environments hadrons melt and the equilibrium state is the quark-gluon plasma. Theoretical control over thermalization at high energies is crucially needed for understanding when and how this equilibrium phase emerges in the experiments. The current theoretical paradigm for thermalization in quantum chromodynamics is based on hydrodynamic and non-thermal attractors (fixed points). They are novel examples of universal dynamics of non-equilibrium quantum fields. Both were found in idealized settings of nuclear collisions with high degree of symmetries and in particular corners of a microscopic parameter space. The goal of High-TheQ is to understand thermalization in quantum field theory beyond these idealizations. Do hydrodynamic attractors appear for off-central nuclear collisions? Is there a gravity dual to a non-thermal attractor? Do non-thermal and hydrodynamic attractors have a common origin, such as spontaneous symmetry breaking? To answer these questions, High-TheQ will adopt an interdisciplinary methodology, including data-driven approaches, mathematics of transseries and higher-curvature gravity. High-TheQ is firmly rooted in my long-term efforts on ab initio modelling of thermalization at strong coupling, pioneering the use of transseries in non-equilibrium dynamics of relativistic systems and introducing hydrodynamic attractors. This gives me a unique opportunity to decisively advance the field with High-TheQ.

Keywords: relativistic hydrodynamics,hydrodynamic attractors,holography,gauge gravity duality,ads cft,non thermal fixed points,non thermal attractors,resurgence,thermalization in quantum field theory,nuclear collisions
Refuelling Heavy Duty with very high flow Hydrogen (RHeaDHy)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: France,Germany,Netherlands
Call: Implementing new/optimised refuelling protocols and components for high flow HRS (HORIZON-JTI-CLEANH2-2022-1, 2022)
Start date: 2023-02-01
End date: 2027-01-31
Duration (months): 48.0
Total project cost (EUR): 4734730.0
EU funding (EUR): 3999381.5
Participants: 11
Project status: SIGNED

There is a strong demand from EU to decarbonise freight transport. RHeaDHy will contribute to this by developing high-performance hydrogen (H2) refuelling stations. RHeaDHy aims at fully implement and validate new refuelling protocols that will allow to refuel 100kg H2 trucks in 1Omin. Partners will design and assembly a new very high flow refuelling line for 700bar H2 truck. To do so, they will develop missing key components needed to reach the mean flow target of 170g/s (300g/s at peak). The unique RHeaDHy comprehensive approach will guaranty an optimal design of components and refuelling line by gathering in the consortium best-in-class partners manufacturing all the components downstream high-pressure refuelling station storage to vehicle storage. This approach will allow to choose the optimal trade-off on constrains repartition among components and to fully consider vision of real vehicle constrains. New implemented refuelling protocols are based on previous work (PRHYDE) and standardization committee work, and involve calculation of refuelling coefficients specific to vehicle storage that need to be derived from hundreds of simulations. This extensive simulation work will be performed on refuelling model validated in previous European projects. To dedicate at least 1.5 years to an extensive test campaign, components and refuelling line design, manufacturing and assembly will be achieved within 2 years. 2 refuelling stations will be installed in France and Germany within the first 2.5 years. 2 truck storage test systems will be used to test and validate refuelling protocols on full scale storage. This work will allow to provide feedback from the field to significantly contribute to the establishment of standards on refuelling interface components and protocols. RHeaDHy will then represent a significant step forward to unlock H2 truck market by allowing wide and performant refuelling station network based on European alternative fuel infrastructures ambition.

Keywords: heavy duty refuelling protocol hydrogen refuelling station very high flow mobility
NMR relaxation tools for improving and protecting quality of dairy products (NMR-IMPROV)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Poland,Portugal,Italy,Türkiye,Germany,Kenya,Lebanon,Tunisia,Algeria
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 1450314.29
EU funding (EUR): 1361600.0
Participants: 14
Project status: SIGNED

NMR-IMPROV proposes a radically new approach to investigating properties of dairy products by exploiting Nuclear Magnetic Resonance (NMR) relaxation, including Fast Field Cycling and Time-Domain NMR methods. The core of the concept is to acknowledge that macroscopic properties of dairy products are largely determined by dynamics of individual molecular fractions (from macromolecules to water) present in the system. Revealing and understanding the dynamics and arrangement of molecular fractions consisting dairy products is essential for providing a foremost guideline for designing products of required rheological properties and texture, avoiding effects such as aggregation or phase separation, and assessing authenticity of the products. The goal of NMR-IMPROV is to form an interdisciplinary and intersectoral network including physicists, chemists, mathematicians, food scientists and engineers and software and electronic engineers to develop NMR relaxation based means to gain knowledge on dynamical properties of dairy products on the molecular level. Relationships between NMR relaxation parameters and macroscopic properties of dairy products, investigated by conventional methods, will be established. The knowledge is meant to be exploited to address challenges of dairy technology associated with development and storage of products that are fermented, plant-based, personalized and manufactured from local raw goods. Moreover NMR-IMPROV aims at establishing NMR relaxation as a tool for evaluating quality and authenticity of dairy products. NMR-IMPROV builds a bridge between specialists from academia, with deep expertise in NMR relaxation, and food scientists and engineers for the ultimate goal of transferring NMR relaxation from academia to dairy industry. This is to be achieved by profiting from the synergy and transfer of knowledge between the parties involved and intensive training of young researchers and industry members.

Keywords: dairy products properties,nuclear magnetic resonance,relaxation,molecular dynamics,quality control,authenticity,food
Custom-Made Designer Macrophages to Revolutionize the Safety of Parenteral Drugs (iPYRO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-01-01
End date: 2024-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The iPYRO proposal is built upon the uniqueness of human induced pluripotent stem cells (iPSC) and recent innovations in the farming of fully defined human macrophages (iMonoMac) using industry compatible bioreactors. Given the growing need for industrial macrophages, iPYRO sets an innovation in the forefront of drug safety evaluations, supplying a unique cell type, which meets the expectations from industry and regulators. The breakthrough innovation of iPYRO will offer a superior, thus highly standardized, economically produced and fully validated “off-the-shelf” macrophage-based cell product to revolutionize the safety of drugs and beyond. To maximize the outcome, iPYRO will assess the regulatory compliance, while further streamlining the iMonoMac product for the envisioned spinout, establishing a proper freedom-to-operate strategy and a suitable business model. The seminal iMonoMac platform along the unique IPR and established contacts to industrial and regulatory stakeholders will pave the transition from academia to industry, introducing for the very first time an iPSC-cell product for the drug safety market market.
European Doctoral Network for Safe and Sustainable by Design Electromagnetic Shielding Material (PARASOL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands,Belgium,Czechia,Poland,United Kingdom,France,Spain
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-11-01
End date: 2027-04-30
Duration (months): 54.0
Total project cost (EUR): 2633238.0
EU funding (EUR): 2633238.0
Participants: 25
Project status: SIGNED

• PARASOL is a Doctoral Network at the intersection of electromagnetic compatibility (EMC), materials engineering, system-safety engineering, and sustainability management. The project will include the Safe and Sustainable-by-Design (SSbD) approach for vehicles. The project researches electromagnetic (EM) shielding solutions, which are performances-defining technologies in terms of EM safety, weight, volume, mechanical strength, and the cost of a vehicle. • PARASOL’s science case is based on the integration and optimisation of every KPI in the SSbD approach. This requires thinking in terms of a trade-off across a new mix of disciplines, to develop innovative solutions accordingly, and to consider all the far-reaching societal and technical consequences of the design choice. Up to now, even most high-tech industries are forced to manufacture several prototypes and perform tests, because the actual performance of shielding in the final vehicles is unknown. A characterisation strategy embedded in the SSbD approach is urgently needed. • PARASOL is the first training network dedicated to the inclusion of the SSbD approach in the design of electronic equipment. It answers the recently highlighted, pressing need for trained specialist in the field. • PARASOL involves 5 academic Beneficiaries and 15 industrial Associated Partners, across the complete lifecycle of design solutions, from 8 countries. A pan-European approach in a multi-sectoral context is guaranteed (universities, an established start-up, SMEs, and major industries), while representing all types of vehicles (land, air, marine). • PARASOL will train a new generation of scientific professionals who can transition between disciplines and take up leading positions in the field of electronics, safety, and sustainability, while thinking differently in terms of design solutions. These professionals can support Europe’s ambition to play a major role in the safety-critical market for vehicles.

Keywords: electromagnetic interference and compatibility,material engineering,system safety engineering,sustainability management
Unraveling Bilobalide Biosynthesis for Sustainable and Scalable Production in Yeast (Biloba.bio)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 263393.28
EU funding (EUR): 263393.28
Participants: 1
Project status: SIGNED

Ginkgo biloba extracts are among the most widely used plant-based health supplements in the United States and Europe. However, increasing demand has led to unsustainable overharvesting, resulting in Ginkgo biloba being classified as an endangered species. These extracts contain bioactive compounds, such as ginkgolides and bilobalide. Bilobalide, in particular, is valued for its neuroprotective, anti-ischemic, and insect-repellent properties, with potential applications in treating Alzheimer’s disease, dementia, sclerosis, and as a biopesticide. To address these societal and environmental challenges, this project aims to develop a scalable, sustainable production platform for bilobalide using synthetic biology in baker’s yeast. This approach will reduce pressure on G. biloba populations, contributing to biodiversity preservation while promoting innovative biotechnological solutions to meet the demand for natural products. A central focus of this research is to elucidate the biosynthetic pathway of bilobalide, which remains poorly understood. It is hypothesized that bilobalide is synthesized either via sesquiterpenoid pathways or through the degradation of ginkgolides. Using complementary experimental systems in yeast and tobacco, I will systematically test both hypotheses to uncover the key biosynthetic steps. Once the bilobalide biosynthesis pathway is elucidated, I will engineer it in baker’s yeast to create a cost-effective, scalable, and sustainable production system. This project will leverage the tools and datasets available in the host lab, along with my expertise in plant secondary metabolism and pathway gene characterization, to achieve its goals. It aligns with the European Union’s priorities of fostering innovation, sustainability, and natural resource conservation, while advancing biotechnology for health and agriculture. Ultimately, this research will contribute to the green transition and aid in the conservation of endangered species like G. biloba.