Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Intelligence-Oriented Verification&Controller Synthesis (InOVationCS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Czechia
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 1995000.0
EU funding (EUR): 1995000.0
Participants: 1
Project status: SIGNED

Software making decisions or controlling cyber-physical systems is ubiquitous, hence its correctness is of paramount importance. While the increasing complexity makes manual implementation extremely error-prone, verification can provide formal guarantees on correctness. Verification of hardware and software has seen many successes and industrialization, making systems safe and reliable and their development more efficient. Controller synthesis goes one step further and avoids the manual implementation, providing a correct-by-construction controller directly. Despite considerable advances, scalable solutions remain elusive here. Artificial intelligence and machine learning (AI/ML) provide scalable solutions to decision making, but at the cost of their reliability, making their verification even more pressing. Besides, the use of AI/ML gives rise to fundamentally new challeges since models, properties and controllers are now often based on data rather than design. Due to their “black-box” nature, the resulting systems are (i) even harder to verify, and (ii) not explainable enough to be responsibly deployed. The PI has been pioneering the use of learning in verification to bring together the best of both worlds, scalability and reliability. The main objective of InOVation&CS is to utilize the power of learning in verification and controller-synthesis to overcome both the traditional scalability challenges as well as the recent, data-driven ones. The key to bringing the two closer than ever is a paradigm shift towards explainability and utilizing structure stemming from the presence of intelligence (human or artificial) in the definition, analysis and solution of real problems, thus providing more information to the learning parts. InOVation&CS shall provide new, more applicable and more scalable methodology for producing guaranteed reliable controllers. Keywords: verification, model checking, Markov decision processes, stochastic games, temporal logics

Keywords: verification,model checking,markov decision processes,stochastic games,temporal logics,artificial intelligence,decision trees,reinforcement learning,neural networks
Group 1 and Group 2 Metal-Metal Bonds. Tailored Reduction Reagents in Synthesis and Catalysis. (MeMe-BONDS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-12-01
End date: 2029-11-30
Duration (months): 60.0
Total project cost (EUR): 1998966.0
EU funding (EUR): 1998966.0
Participants: 1
Project status: SIGNED

The increasing demand for environmentally friendly reagents to perform sustainable processes has become of paramount relevance for modern academia and industry. Transition metal-based catalysts are long-established players in many important chemical transformations, given their ability to cleave and form chemical bonds with facile oxidation state changes. Their high cost and/or toxicity, however, have prompted the search for potential replacements. The past decades brought fascinating discoveries of main-group-based species exhibiting low-oxidation states and/or metal–metal bonds with excellent and tunable reducing properties. Nonetheless, despite formidable efforts invested in broadening the scope, existing examples are restricted to Mg-containing molecules, while other s-block metal-metal bonds remain unaccomplished. MeMe-BONDS will address this challenge by engineering novel sustainable reductants based on hitherto unknown s-block bonds stabilized by tunable electronic interactions. This breakthrough will be possible by combining the steric shielding provided by commonly used ligands with the introduction of a σ-acceptor functionality to tame the inherent reactivity of formed radical intermediates. This innovative metal-ligand interaction will allow for the precise incorporation of one or two extra electrons, resulting in a unique electronic structure, which - under suitable conditions - will afford the new s-block metal–metal bonds. Tandem experimental and computational methods will enable a fundamental understanding of the electronic structures and their interplay with the nature of the substituents. The properties and reactivity of these novel bonds will be thereby tuned, opening the door for application in small molecules’ activation and as electronically versatile catalysts. The output of this project will enrich the synthetic chemistry toolbox and pave the way for more environmentally friendly chemical processes.

Keywords: s block,main group chemistry,low valent,oxidation state,chemical bonding
Production of a new biodegradable bioplastic made up of biomolecules extracted from expired milk (SP-Milk)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

The global plastic production reached up to 400.3 million metric tons in 2022, of which approximately 8 million tons are entering into the oceans every year. The imprudent use of plastics in our everyday life elevated plastics into the major pollutant component of the world seas and oceans. At the same time, every year in Europe 3-6 million tons of milk are thrown away as waste. Splastica is an innovative startup and a spin off from University of Rome Tor Vergata founded in 2019, whose CEO is a woman, which found an innovative way to turn expired milk into a biobased and biodegradable plastic, by means of a patented process. This bioplastic has been widely characterized, showing good hardness, resistance and great stability in a wide range of temperatures, and in contact with food, water, detergents. The single-use plastic industry is the target field of application of SP-Milk bioplastic. Single-use plastics, often also referred to as disposable plastics, are commonly used for plastic packaging and include items intended to be used only once. Following the new proposal on packaging and packaging waste regulation, the target field of our material will be the applications where the EU has found genuine environmental benefits in using such kind of materials: bags for the separate collection of biowaste, very light plastic carrier bags, tea bags, filter coffee pods, fruit and vegetable stickers, mulch films used in agricolture, SPlastica business idea is to bring to the market SP-Milk bioplastic in the form of granules to be used by plastic processing companies with injection moulding and compression moulding machines or to produce films for industrial applications. Project Objectives within the EIC Accelerator are: the optimization of the bioplastic formulation to refine its machinability with injection moulding industrial machines; the material certifications and the realization of an industrial scale plant.

Keywords: bioplastic biopolymers bio based compostability plastic processing
Post-Quantum Side-Channel Attack Resilience (PQSCAR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Luxembourg
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-05-01
End date: 2026-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

In the rapidly evolving digital age, the advent of quantum computing poses a significant threat to current cryptographic standards, leaving sensitive information vulnerable to quantum-based attacks. This project addresses the urgent need for resilient cryptographic solutions capable of withstanding quantum threats, focusing on developing and validating post-quantum cryptographic algorithms that are resistant to side-channel attacks. Our solution involves the creation of a robust framework for evaluating the resilience of cryptographic algorithms against quantum and side-channel attacks. By leveraging advanced mathematical models, simulation tools, and hardware implementations, we aim to identify and mitigate vulnerabilities in existing cryptographic systems, ensuring a high level of security in the quantum computing era. Collaboration with industry partners and academic institutions will play a crucial role in validating the effectiveness of our solutions across different platforms and use cases. This project not only aims to advance the field of cryptography in response to quantum computing challenges but also to establish a set of standards and best practices for developing and implementing post-quantum cryptographic solutions, ensuring the long-term security of digital information.
Strengthening Ethics and Responsible conduct of Clinical Trials in East and Sub-Saharan Africa (SERCEA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Coordination and support actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Netherlands,Uganda,Tanzania, United Republic of,Malawi,Kenya
Call: Strengthening regulatory capacity for supporting conduct of clinical trials (HORIZON-JU-GH-EDCTP3-2022-01, 2022)
Start date: 2023-07-01
End date: 2026-06-30
Duration (months): 36.0
Total project cost (EUR): 599000.0
EU funding (EUR): 599000.0
Participants: 5
Project status: SIGNED

The increased number of Clinical Trials taking place in Africa as well as the complexity of Clinical Trials designs require that the countries have the regulatory capacity to review, monitor and utilize data generated from the research. Research Ethics Committees/Institutional Review Boards, Institutional Animal Care and Use Committees and National Regulatory Agencies (NRAs) are required to be abreast with the evolving landscape thus require continuous capacity building as well as have platforms to share Clinical Trials information with both the public and private sector. The 11th Annual National Research Ethics Conference held in 2021 in Uganda highlighted challenges in the low and middle income countries for research ethics and open science specifically, the lack of infrastructure for open data sharing and fair data management. Specifically, i) lack of the national and regional guidelines and codes of conduct for scientific integrity ii) limited training and education in responsible conduct of research and pharmacovigilance. This proposal focuses on strengthening ethics and responsible conduct of Clinical Trials in East and Sub-Saharan Africa project through the establishment of a research ethics and integrity framework, open data access framework for Clinical Trials, E-learning platform for the Good Research Regulatory Research Practice Course and establishing Research Ethics Committees in National Regional Hospitals. The consortium will leverage on the legal establishment of the institutions, collaborative efforts with the partner institutions, East African Health Research Commission (EAHRC), African Vaccine Regulatory Forum (AVAREF). Having a robust regulatory system, encompassing research integrity and open science will ensure that Clinical Trials is conducted to the highest ethical standards and in compliance with existing polices and laws, hence protection of safety, rights and welfare of the individual participants, community, researcher and sponsors.

Keywords: ethics,research integrity,clinical trials
NOVA Institute for Medical Systems Biology (NIMSB)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Portugal,Germany
Call: Teaming for Excellence (HORIZON-WIDERA-2022-ACCESS-01-two-stage, 2022)
Start date: 2023-09-01
End date: 2029-08-31
Duration (months): 72.0
Total project cost (EUR): 14992000.0
EU funding (EUR): 14992000.0
Participants: 2
Project status: SIGNED

The rise of chronic diseases is shaping health policy priorities worldwide. As the population ages, these conditions affect increasing portions of society and are more difficult to manage, causing suffering in patients and their families for many years. Such increasing prevalence is a threat to the sustainability of healthcare systems. Thus, an increasing focus has been put on disease prevention and awareness, as well as on precision medicine. This project will create a new Centre of Excellence, NOVA Institute for Medical Systems Biology (NIMSB), which will use the most advanced cell analytics and experimental in vitro systems, combined with computational approaches to understand and fight chronic diseases. The core of the project will be the integration of multi-omics data from single cells from patient biopsies and derived organoids, bioinformatics and artificial intelligence, cell and molecular biology, and relevant animal model studies, to develop quantitative models that can inform on mechanisms of disease progression. Researchers and clinicians will collaborate to use this knowledge to implement novel precision medicine solutions, aiming to intercept diseases before symptoms develop, and also by improving diagnosis, disease course prediction and response to treatment. NIMSB will contribute to clinical practice improvement not only with technology but also by training the next generation of researchers and medical doctors in precision interceptive medicine and digital-transformation technologies. NOVA Medical School of NOVA University is in a unique position to coordinate the project due to its current drive for restructuring, established reputation as a top Medical School in Portugal, and research focus on chronic diseases. The Max Delbrück Center for Molecular Medicine is the best possible advanced partner, as it is a world leader in this research topic and has recently created the Berlin Institute for Medical Systems Biology, which is a model for NIMSB.

Keywords: systems biology,systems medicine,interceptive medicine,precision medicine,organoids,artificial intelligence,mechanisms of disease,single cell sequencing,multiomics
Molecularly informed dense connectomic mapping of mammalian brain tissue (MOLCONN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing , nervous system  function and dysfunction , systems neuroscience  and modelling , biological basis of cognitive processes and of behaviour, neurological and mental disorders – In humans and all other organisms
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2843750.0
EU funding (EUR): 2843750.0
Participants: 1
Project status: SIGNED

Complex wiring between neurons underlies the information processing network enabling all brain function. Fundamental questions on how the network is organized, how structural connectivity relates to the cells’ molecular machineries and how cells, synaptic connections, and circuits evolve over time remain enigmatic. Addressing these questions is beyond the limits of current measurement technologies, as these either lack resolving power to untangle cellular connectivity or can’t visualize the molecular characteristics of cells, such that these functionally highly interlinked modalities of information remain disconnected in current analysis. Here, we will devise transformative optical imaging technologies for multi-molecular mapping in relation to dense, synaptic resolution connectomic reconstruction of the same cells. We will directly integrate multiplex protein information and in-situ gene expression profiling with connectomic reconstruction. This will reveal cell types and states and the molecular machineries involved in intercellular signaling mapped, onto neuronal morphology and synaptic connectivity patterns. The technology will be based on high-fidelity expansion microscopy with combined structural and multi-molecular readout. We will apply MOLCONN to study the functional architecture of brain tissue across development and ageing in healthy mice with unprecedented information content. We will then define multi-modal organizational rules in human brain tissue. Analysis of the ageing brain will serve as reference frame to bridge from genotype/disease states to tissue-level functional phenotypes in neurodegenerative disease in a mouse model of Parkinson’s disease. We will use a uniquely cross-disciplinary approach integrating developments in imaging, sample preparation, molecular labeling, and computational data interpretation to build unified models of molecular and structural circuit properties to address the fundamental question of how these interrelate.

Keywords: connectomics,dense brain tissue reconstruction with synaptic resolution,light microscopy based connectomics,liconn,expansion microscopy,multi molecular
Building Identity: Religious Architecture and Sacral Landscapes of Christian Minorities in India and Bangladesh (ID-SCAPES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Portugal
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1999493.0
EU funding (EUR): 1999493.0
Participants: 1
Project status: SIGNED

The cultural heritage associated with India and Bangladesh’s Christian minorities remains understudied and its historical significance is often contested. Many of the countries’ medieval and early modern churches were built primarily for communities of newly converted Christians that came from different regions and caste backgrounds and therefore carried corresponding identities. Even today, many of South Asia’s churches reflect these local identities and traditions, with factors such as caste, “indigenous” agency, and cultural “accommodation” playing a role in their social and architectural history. These contexts originated distinct regional architectural expressions in the countries’ six main Christian ethnolinguistic communities (East Indians, Goans, Mangaloreans, Keralites, Tamils and Bengalis) However, most scholarly work has addressed the design of these churches against the background of European artistic tendencies - such as mannerism or baroque - while local contexts and traditions have remained overlooked. Today, as dominant groups assert hegemonic policies across South Asia, religious minorities face increasing challenges, and their cultural heritage is oftentimes at risk. Many of South Asia’s churches founded before ca. 1800 have disappeared, are in ruins or have been deeply transformed, and there is a sense of urgency in documenting the churches that remain. ID-SCAPES will produce a Social History of the Built Environment of India and Bangladesh’s medieval and early modern churches and sacral landscapes, uncovering the influences of diverse agencies, identities and traditions on their overall design. By producing knowledge on this body of architecture, with in-depth analysis providing vision for contested and/or endangered sites, the project will ascertain how churches are vital in framing the collective identities of Christian minorities today, thereby nurturing their resilience and contributing towards the diversity of South Asia’s cultural heritage

Keywords: cultural heritage early modern history entangled histories caste
Scaling the HoegTemp high-temperature industrial heat pump to market leading cost and performance (HyScale)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Norway
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2495000.0
EU funding (EUR): 2495000.0
Participants: 1
Project status: SIGNED

Enerin AS, a Norwegian SME founded in 2017, specializes in industrial High-Temperature Heat Pumps (HTHP) called “HoegTemp,” which reach up to 250°C. Their engineers lead in HTHP technology and energy efficiency projects. In Europe, there's a high demand for heating between 100°C and 200°C, especially in food production and drying. Currently, 77% of this heat comes from fossil fuel boilers, but HTHPs could meet a majority of this demand, reducing emissions. The industrial heat pump market is projected to grow over 15% annually until 2030. Enerin, with its advanced HoegTemp technology, is poised for success. The HoegTemp, featuring 3, 6, and 12-cylinder compressors with integrated heat exchangers, operate on the Stirling cycle with helium as refrigerant. Helium will be replaced by clean hydrogen for additional efficiency during the project. HoegTemp achieves a high coefficient of performance (COP) of 50%-60% of Carnot at high temperatures. With one pilot installation in Norway running over 6000 hours, and three new contracts signed, Enerin’s HoegTemp is at TRL 7. We aim for TRL 9 by 2027 (TRL8 with hydrogen). By increasing capacity, standardizing systems, and reducing component costs and complexity, Enerin aims to cut installation and operation costs by 50%-70%, compared to current cost making its HTHPs the most cost-effective option for industrial heating in Europe. Enerin has secured funding for R&D and prototypes but is facing challenges in raising private capital. The company is now seeking €2.495 million in EIC grants and up to €10 million in equity or quasi-equity funding to enhance efficiency, scalability and competitiveness needed for future market expansion.

Keywords: industrial heat pump,energy recycling,sustainable process heat,renewable refrigerant