Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
LINEAR INFRASTRUCTURE EFFICIENCY IMPROVEMENT BY AUTOMATED LEARNING AND OPTIMISED PREDICTIVE MAINTENANCE TECHNIQUES (INFRALERT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Germany,Sweden,Hungary,Portugal
Call: Smarter design, construction and maintenance (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 36.0
Total project cost (EUR): 3183243.75
EU funding (EUR): 3183243.75
Participants: 8
Project status: CLOSED

INFRALERT aims to develop an expert-based information system to support and automate linear asset infrastructure management from measurement to maintenance. This enfolds the collection, storage and analysis of inspection data, the deduction of interventions to keep the performance of the network in optimal condition, and the optimal planning of maintenance interventions. It will also assess new construction strategic decisions. The condition of the land transport infrastructure has a big societal and economic relevance, since constraints result in disruptions of service. The demand for surface transport will significantly increase in the next years. Given budget restrictions, a substantial enlargement of the road/rail network in the next decades is doubtful. Besides, the aging infrastructure will require more maintenance interventions which infer normal traffic operation. Therefore, the only way to increase infrastructure capacity for the increased transportation demand is to optimise the performance of the existing infrastructure. This issue is addressed by INFRALERT. INFRALERT will develop and deploy solutions that enhance the infrastructure performance and adapt its capacity to growing needs by: (i) ensuring the operability under traffic disruptions; (ii) keeping and increasing the availability by optimising operational maintenance interventions and assessing strategic long-term decisions on new construction; and (iii) ensuring service reliability and safety by minimising incidences and failures. INFRALERT will be directly applicable by Rail and Road Infrastructure Managers in the field of Intelligent Maintenance and long term strategic planning. Two real pilots (for roads and rail transport systems) will be used to validate and demonstrate the results of the research activities. In both cases, extensive data from auscultation campaigns are available since some years ago. The empirical development of the whole project will be based on these pilot cases.

Keywords: infrastructure management,intelligent maintenance,predictive modelling,decision support tools,data mining
Biocatalytic alkylation: fitting enzymes for selective C-C bond formations (BioAlk)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1625000.0
EU funding (EUR): 1625000.0
Participants: 1
Project status: SIGNED

Alkylation, in particular carbon-carbon (C-C) bond formation, is one of the most important and challenging synthetic transformations in chemistry. Current chemical approaches for C-alkylation require the use of expensive and toxic transition metals with complex ligands that have limited selectivity. Developing sustainable methods for the controlled formation of C-C bonds with regio- and stereospecificity in high yields has the potential to change organic chemistry and provide access to new molecules. Enzymes, Nature’s catalysts that enhance reaction rates, can selectively catalyze such reactions, with current limitations due to high energy co-substrates and the requirement for specific starting materials, sometimes leading to undesired side products, therefore unsustainable to upscale. I aim at developing the synthetic potential of key oxidoreductase enzymes towards the sustainable selective production of highly valuable compounds through C-C bond formation. Oxidoreductases traditionally catalyze reduction and oxidation reactions and are increasingly used at industrial scale for their mild reaction conditions and exquisite chemo-, regio- and stereoselectivity. I will use the inherent mechanism of two particular oxidoreductases, ene reductases and alcohol dehydrogenases, and develop them towards selective C-C bond formation. BioAlk aims at being disruptive in catalysis and organic synthesis by enabling new approaches for bench mark sustainable methods towards highly selective biocatalytic C-alkylation with industrially relevant oxidoreductases. I will design and develop non-natural enzymatic processes with ene reductase-catalyzed selective inter- and intramolecular α-alkylation of carbonyl and related compounds, and alcohol dehydrogenase-catalyzed nucleophilic reductive alkylation, while exploring the enzyme reaction mechanisms.

Keywords: biocatalysis,selective alkylation,organic synthesis,oxidoreductases
The Kurds in Syria: A complex interplay between local, regional and transnational (ROJAVA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

While extremely graphic images from the Syrian civil war appearing at the world media, smiling young Kurdish female guerrillas at the cover of magazines such as Elle, Marie Claire presented another picture. Kurdish fighters have become driving forces in offensives against ISIS and gained worldwide news coverage. However, the story of the Kurds in Syria is more than this. The Kurds who had been deprived of their fundamental national rights, including the citizenship had no status in Syria. With the collapse of the central state, they carved out three enclaves, named them Cantons and declared a de facto autonomous region in northern Syria. So, rather than talking about the ‘jihad’, as most of the other rebels did; they engaged in creating a self-governing model based on this area, called Rojava in Kurdish. That model based on criticizing the existing nation-states in the region promoted the equality between different (ethnic/religious) groups, advocated the empowerment of women and functioned on the bottom-up constructed local councils as the main sites of governance. This project which looks at how alternative spaces of governance are created investigates the emergence of that model in that autonomous region, tracing back to its ‘founding ideas’ and also look at the influence of the self-governing experience of the Kurds in Syria on the Kurds in Turkey and Iraq. So it aims to contribute to the understanding of the behaviour of the groups in a civil war and of the possibilities in creating a successful transition to a post-war context. In doing this, it aims at bringing the different perspectives and scales into the same analysis. Furthermore, the project aims to connect discussions of place making and constitutive politics with that of social movements.

Keywords: kurds,syria,turkey,iraq,rojava,cantons,spaces of governance,autonomy
Game-changing Precision Medicine for Curing All Myeloproliferative Neoplasms (ChAMPioN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 3005817.75
EU funding (EUR): 2856679.0
Participants: 2
Project status: CLOSED

Despite decades of research, developing ways to overcome drug resistance in cancer is the most challenging bottleneck for curative therapies. This is because, in some forms of cancer, the cancer stem cells from which the diseases arise are constantly evolving, particularly under the selective pressures of drug therapies, in order to survive. The events leading to drug resistance can occur within one or more individual cancer stem cell(s) – and the features of each of these cells need to be studied in detail in order to develop drugs or drug combinations that can eradicate all of them. The BCR-ABL+ and BCR-ABL- myeloproliferative neoplasms (MPN) are a group of proliferative blood diseases that can be considered both exemplars of precision medicine and of the drug resistance bottleneck. While significant advances in the management of MPN have been made using life-long and expensive tyrosine kinase inhibitors (TKI), patients are rarely cured of their disease. This is because TKI fail to eradicate the leukaemia stem cells (LSC) from which MPN arise and which persist in patients on treatment, often leading to pervasive drug resistance, loss of response to therapy and progression to fatal forms of acute leukaemia. My goal is to change the way we study the LSC that persist in MPN patients as a means of delivering more effective precision medicine in MPN that is a “game-changer” leading to therapy-free remission (TFR) and cure. Here, I will apply an innovative strategy, ChAMPioN, to study the response of the MPN LSC to TKI in innovative pre-clinical laboratory models and directly in patients with MPN - up to the resolution of individual LSC. This work will reveal, for the first time, the molecular and clonal evolution of LSC during TKI therapies, thus enabling the development of more accurate predictions of TKI efficacy and resistance and rational approaches for curative drug therapies.

Keywords: bcr abl,jak2,bioinformatics,modelling,nrg xenograft,tyrosine kinase inhibitors,ezh2,c myc,bar coding,single cell,precision medicine,heterogeneity,clonal evolution
Nacht der Wissenschaft in der Kiel Region 2018/2019 (SCIENCE4FUTURE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Germany
Call: European Researchers' Night (H2020-MSCA-NIGHT-2018, 2018)
Start date: 2018-05-01
End date: 2019-12-31
Duration (months): 20.0
Total project cost (EUR): 166750.0
EU funding (EUR): 166750.0
Participants: 1
Project status: CLOSED

Following the resounding success of the first NIGHTs in 2016/17, SCIENCE4FUTURE will once again in 2018 and 2019 bring together all of Kiel Region’s 14 research organisations comprising all academic disciplines to showcase their scientists and work to the public. With 5 participating cities (Kiel, Rendsburg, Eckernförde, Plön and Preetz) and over 30 supporting institutions from the public, private and non-governmental sector, it will be the largest public event dedicated to science in Northern Germany. A multifaceted awareness campaign with live broadcasts during the NIGHTs will reach 80% of the households. More than 100 activities per NIGHT will give the public a chance to personally talk, work and play with scientists thus breaking down stereotypes. SCIENCE4FUTURE will focus on the general themes of identity (to celebrate Europe’s Cultural Heritage), mobility, diversity and Europe, which are ideally suited to showcase the whole spectrum of social, environmental and economic benefits that our researchers achieve every day. Free shuttles will allow visitors (minimum 12,000 expected visitors per NIGHT) to see the broad range of local, national and European research projects in our region. With a careful choice of venues (eg malls, cinemas, night clubs), the involvement of schools, a targeted publicity campaign and a fun-filled programme, the two NIGHTs will attract particularly children and young People, including those usually less interested in academia. Researchers will demonstrate simple “take-home” experiments to teachers, nursery staff and parents to ensure that the interest for research sparked during the event is kept alive beyond the NIGHT. Moreover academic support services (international, student admissions and diversity offices) will offer advice on career options. With the strong support of all stakeholders and the active involvement of over 200 researchers in the design and delivery of the programme SCIENCE4FUTURE will become a regional flagship event.

Keywords: outreach,education,research,identity,inclusion,diversity,career,europe,mobility,teachers,ethics,non formal education,innovation,non governmental sector,public sector,science
Development of Thiophene Based Conjugated Polymers in Two Dimensions (T2DCP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-03-01
End date: 2024-08-31
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The proceeding inexorable digitalisation of modern economics and society creates a steadily increasing demand on smart devices in the context of the industrial internet and the internet of things. To meet future requirements, organic electronics is a disruptive technology featuring low-cost, robust, lightweight, flexible and affordable devices based on organic small molecules and polymers. In contrast to the boosting development of linear conjugated polymers and their applications in organic electronics, the successive increase of dimensionality by connecting multiple strands towards two-dimensional (2D) conjugated polymers remains largely unexplored. In this project, we will develop unprecedented thiophene-based double- and triple-strand conjugated polymers to 2D conjugated polymers (T2DCPs) for organic electronics with tailorable electronic band gap at the molecular level for superior performance in terms of charge carrier mobility, and defect tolerance enabled by the increased dimensionality. In this respect, we aim to establish versatile but also reliable solution-based synthesis strategies (one-pot solvothermal, two-step metal-templating reaction and interfacial soft-templating route) employing thiophene monomers rendering T2DCPs with entirely C=C/Ar-Ar backbone. We will further establish ground-breaking one-pot synthesis of donor-acceptor type T2DCPs featuring lower band gap and unique charge transport behavior. By employing designed thiophene-based monomers and linkage topologies, we will accomplish optical and energy gap engineering, control of the molecular weight (or crystalline domain size), and conjugation channel densities. The consequence is that we will explore the key functions of this intriguing class of semiconducting polymers. As the key achievements, we expect to establish a novel solution-based chemistry, delineation of reliable structure-property relationships and superior device performance of T2DCPs for organic field effect transistors.

Keywords: two dimensional conjugated polymers,organic electronics,semiconducting polymers,2d materials
PEER LEARNING OF INNOVATION AGENCIES FOR ADVANCED SUPPORT TO SCALE-UPS (Scale-ups Ready)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Spain,Lithuania,Greece
Call: Peer learning of innovation agencies (H2020-INNOSUP-2018-2019-05, 2018)
Start date: 2018-10-01
End date: 2019-06-30
Duration (months): 9.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

Following international evidence that shows that a small number of high-growth firms are vital for job growth and overall economic growth, and the European Commission's Start-up and Scale-up Initiative, Enterprise Europe Network (EEN) launched in 2017 a new flagship service to support scale-ups. However, innovation agency services are in too many occasions standardised and do not take into account the rapid evolving entrepreneurial ecosystem and the advanced needs of scale-ups. Innovation agencies across Europe need to be ready today to deliver advanced assessment services to scale-ups and be able to offer support tailored to their needs. The objective of Scale-ups Ready is to enable the participating innovation agencies to exchange knowledge, know-how, and good practices on advanced methodologies and tools for scale-ups assessment (including SMEs with high-growth potential) and customised support services, in order to develop better approaches for client intake and support of scale-ups. Based on the Twinning+ methodology, the project aims to cover peer-learning and peer-review activities for three kinds of services through specific assessment instruments that when combined offer in-depth analysis of the needs of scale-ups, in order to provide them with tailored support: 1) An advanced IP valuation scheme, IPscore® 2.2 (FORTH), 2) An advanced business innovation roadmap tool, smE-MPOWER ‘Business innovation roadmap tool’ (LIC), 3) An advanced Innovation Health Check assessment tool (FUNDECYT-PCTEX). This peer-learning and peer-review scheme has been developed based on each partner's identified competences and gaps in advanced services for scale-ups. The result will bring in new added-value service offerings to participating organisations, will lead to better approaches and the adaptation of tools to the specific national/regional contexts. The Design Options Paper will be shared with other EU innovation agencies and networks, and with national and EU policy-makers.

Keywords: scale ups,peer learning,innovation agencies,assessment tools,advanced support services,tailored services
Aromatic stacking in Glycochemistry: can glycosidations be tamed? (SWEET-PI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Progress in chemical synthesis has provided access to a large variety of complex glycostructures, having a major impact in the expansion of Glycoscience. Central to carbohydrate chemistry is the glycosidation reaction, which involves the formation of a glycosidic bond between donor and acceptor molecules. It is commonly accepted that this process requires the formation of transient ionic species, whose stability, conformational properties and interactions determine to a large extend the reaction outcome. In principle, these elusive species are stabilized by means of inter- and intramolecular interactions, and in fact, this is a key feature for the activity of glycosidases and glycosyltransferases, typically requiring the participation of electron-rich functional groups, such as carboxylates. Interestingly, aromatic/carbohydrate interactions have too been detected and evaluated as supramolecular recognition motifs but, to the best of our knowledge, never at the reaction intermediate level, despite being frequently invoked to play a major role during enzymatic catalysis. Our hypothesis in this project revolves around the idea that stacking interactions involving electron-rich aromatic systems can be employed to stabilize the glycosyl oxocarbenium ion and to enhance the glycosyl acceptor reactivity; in the first case, these contacts might increase the life-time of the cationic intermediates, facilitating their detection and potentially allowing the modulation of the glycosidic donor in order to better control the stereochemical course of the reaction. Alternatively, CH/pi complexes involving the glycosyl acceptor could enhance the electron density of the reactive functional group, thus its nucleophilicity. This project aims to test both aspects of the carbohydrate/aromatic interaction employing a bioorganic approach based on the design, synthesis and systematic analysis of appropriate molecular models.

Keywords: glycochemistry,glycosidation,ch pi stacking,oxocarbenium ion,reaction intermediate,stereochemical control
Towards a Sophisticated SIEM Marketplace for Blockchain-based Threat Intelligence and Security-as-a-Service (PUZZLE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Improve cyber security
Action type: Innovation actions
Countries involved: Israel,Germany,Cyprus,Serbia,Belgium,Greece,Greece,Greece,France,Denmark,Luxembourg
Call: Digital Security and privacy for citizens and Small and Medium Enterprises and Micro Enterprises (H2020-SU-DS-2019, 2019)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 5269816.08
EU funding (EUR): 3999933.75
Participants: 14
Project status: SIGNED

PUZZLE will implement a highly usable cybersecurity, privacy and data protection management marketplace targeted at SMEs&MEs that enables them to monitor, forecast, assess and manage their cyber risks through targeted cybersecurity services, increase their cybersecurity awareness through the efficient heterogeneous information processing, the establishment of knowledge sharing with other SMEs&MEs and extract insights based on advanced analytics. The PUZZLE will track the relationships among the cyber assets of each SME&ME, considering the available network, compute and storage infrastructure and use them to efficiently calculate individual, cumulative and propagated risks, as well as recommend and apply mitigation actions. The PUZZLE will support vulnerabilities and threats assessment in a collaborative manner based on the homogenization of data provided by the SMEs&MEs. Data will be collected by resource handling and monitoring agents applied over Cloud/Edge Computing, IoT and network infrastructure. Such data will be enriched with data provided in relevant open repositories. SMEs&MEs data sharing will take place through blockchain-based technologies for secure data management. Based on the calculated risks and the provided graph topology, the application of resilient defensive strategies will be recommended, considering the type of infrastructure used by the SME&ME. Automated defensive strategies deployment mechanisms are also going to be made available, reducing a lot the complexity and the burden for the deployment of the provided services by cybersecurity managers in SMEs&MEs. Special emphasis will be given on the usability and the rise of competitiveness of the PUZZLE Marketplace, by designing solutions that can be easily on-boarded by external cybersecurity providers and can be seamlessly adopted by the end-users taking into account their preferences. The provided services will be made accessible through the SMEs&MEs Dashboard that will be developed.

Keywords: collective threat intelligence and blockchain,easy to deploy services,smesandmes personalized recommendations,policy based deployment recommender,edge trust assurance