Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
BioInspired Clicked Siderophore-Antibiotics (ANTIBIOCLICKS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The frightening increase in antibiotic drug resistance is threatening global healthcare as we know it. To this extent the World Health Organisation that has classes M. tuberculosis and Gram-negative nosocomial infections as the highest priority for novel R&D strategies. A major obstacle to drug discovery programs is to design inhibitors that can efficiently enter into bacteria. One such stealth strategy is exemplified by natural siderophore-antibiotics conjugates (sideromycins) that piggyback the bacterial iron acquisition machinery to enter bacteria. This Trojan-horse strategy has inspired the chemical synthesis of numerous sideromycin conjugates, with cefiderocol a current preclinical candidate. Despite the advances in this field, natural examples of sideromycins are still scarce, and finding new examples may provide further insight into siderophore antibiotic formation and delivery. ANTIBIOCLICKS will investigate a unique bioinspired conjugation chemistry that has been uncovered from a newly discovered natural sideromycin. This natural “click” chemistry is ideal for the coupling of catecholate containing siderophores (such as those of the WHO prioritised M. tuberculosis, A. baumannii, E. coli, P. aeruginosa and K. pneumonia) to antibiotics or other molecules. This project will aim to define the exact chemical mechanism behind this novel and surprisingly simple conjugation reaction, and use this unique and facile chemistry to generate a combinatorial library of siderophores with antibiotics and fluorophores. These products will subsequently be used to probe the exact mechanism of bacterial sideromycin uptake, potential intracellular decoupling and target engagement. Finally, the antibiotic and diagnostic potential of the generated siderophore conjugates will be evaluated. To this extent, ANTIBIOCLICKS will provide illuminating insight into new bioinspired conjugation chemistry, and evaluate its potential for novel bacterial therapeutics and diagnostics.

Keywords: sideromycin,conjugation,antibiotic,siderophore,combinatorial,trojan
Cloud-MicroPhysics-Turbulence-Telemetry: An inter-multidisciplinary training network for enhancing the understanding and modeling of atmospheric clouds (COMPLETE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Israel,Italy,Germany,Italy,Poland,France,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-06-01
End date: 2021-01-31
Duration (months): 56.0
Total project cost (EUR): 3545328.09
EU funding (EUR): 3545328.09
Participants: 9
Project status: CLOSED

Clouds are the largest source of uncertainty in weather prediction, climate science, and remain a weak link in modeling atmospheric circulation. This is rooted in the fact that clouds depend on the physical and chemical processes over a huge range of scales, from the collisions of micron-sized droplets and particles to the airflow dynamics on the scales of thousands of meters. Since ambiguities related to representation of clouds in climate models prevail, explorative observations are still needed. The challenge is on the one hand to establish connections across this range of scales, from aerosol and particle microphysics to macro-scale turbulent dynamics in clouds, and on the other to combine knowledge and training across vastly different scientific and engineering disciplines. The aim of COMPLETE is to develop an inter/multidisciplinary training network that will prepare high-potential early stage researchers (ESRs) with both scientific and industrially-oriented skills that will advance our understanding in these multi-scale complex natural phenomena. COMPLETE will vastly improve Europe’s position as a global leader in technology, science and innovation to address climate change challenges. The training programme will combine the scientific investigation of specific aspects of cloud physics and related turbulent dynamics with training in key professional skills. This comprises an exceptional experimental programme that includes field experiments, laboratory and numerical simulations, the design and development of advanced fast temperature probes, velocity MEMS and innovative atmospheric mini radio-sondes; all aimed at the production of new, Lagrangian based, cloud fluctuation datasets, required to reduce the fragmentation of results and knowledge in this field.

Keywords: warm clouds,turbulent entrainment,remote sensing,radiosondes,lidar,aerosol spectrometers,lagrangian tracking,droplet generators,in situ experiments,laboratory experiments
The use of proportional palliative sedation for the relief of refractory symptoms: an international multicenter study (PalliativeSedation)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Belgium,Belgium,Belgium,Hungary,Romania,Netherlands,United Kingdom
Call: Novel patient-centred approaches for survivorship, palliation and/or end-of-life care (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 4033520.75
EU funding (EUR): 4033520.25
Participants: 11
Project status: SIGNED

Due to the rise in cancer and multiple chronic disease, the number of patients with refractory symptoms, ie severe symptoms where conventional treatment options fail, is likely to increase. In such cases palliative sedation (PS) can be indicated which involves the intentional lowering of consciousness at the end of life. However PS is too often restricted to continuous deep sedation and confused with hastening of death. This proposal offers a modified concept, namely proportional PS, with titration of sedatives up to the point of symptom control to improve patient comfort. Firstly, the project will offer a review about state-of-the-art refractory symptom management and a country survey. Secondly, an observational multicenter study will be performed in five countries to study the effect of proportional PS at patient comfort and symptom relief. Thirdly, a multiple case study of 50 cases will investigate caregivers and family experiences. Fourthly, moral case deliberation will be studied as a tool to improve multidisciplinary decision making for the treatment of refractory symptoms/PS in 16 clinical centers in 8 countries, including the effect on caregiver emotional distress. Fifthly, a Cost Consequence Analysis will be provided to feed a policy workshop and recommendations for the further development of palliative sedation in Europe. Sixthly, a revision of the 2009 EAPC framework for PS will be undertaken, using a Delphi procedure. Finally, a free online education programme will be delivered together with an abook and a closing congress and webinar to support dissemination. The project consortium consists of experts in the field of palliative care and PS from 8 North-Western, Southern, and Central-Eastern European countries. Renowned advisory board members are involved among which the European Cancer Patient Coalition to foster the patient perspective. A dedicated European taksforce for PS is foreseen as a follow up after the project's finalization.

Keywords: palliative sedation,refractory symptoms
5th GeneratiOn Security for Telecom Services (5GhOSTS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden,Belgium
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-09-01
End date: 2024-02-29
Duration (months): 54.0
Total project cost (EUR): 1076605.92
EU funding (EUR): 1076605.92
Participants: 2
Project status: SIGNED

5GhOSTS (5th GeneratiOn Security for Telecom Services) will analyze and improve the security of service-based implementations of 5G networks, relevant to protect the EU’s critical communication infrastructure. Based on the upcoming service-based architecture for 5G by the 3GPP, which includes virtualization of network functions, 5GhOSTS aims to strengthen the security of light-weight virtualization. State-of-the-art technologies in this field do not meet the stringent security, privacy and performance requirements of telecommunication systems. 5GhOSTS addresses these challenges by forming an international and interdisciplinary research group that works towards releasing a number of building blocks for secure light-weight virtualization and container orchestration technology for 5G networks. These building blocks will come with a strong, well-understood and formalized notion of security. They will further comply with legal data protection requirements, implementing these requirements in reusable middleware rather than application level. 5GhOSTS fosters standardization in the mobile networks of the future, focusing on security and privacy. Under the supervision of ICT and law researchers from Ericsson and KU Leuven, 4 ESRs will develop competitive and interdisciplinary profiles. In line with the EU’s vision on doctoral training, open science and sustainable development, 5GhOSTS’ ambitious training network leverages academic excellence and a strong business- and innovation-oriented mindset, to let the ERSs develop technical and transferable skills with a thorough understanding of legal and business aspects. As such, 5GhOSTS address the growing need of the EU economy for young researchers with a strong profile (technical, legal and economic) in the 5G telecommunications domain, increasing the researchers’ international competitiveness.

Keywords: virtual network functions,security,privacy,lightweight virtualization,containers,container orchestration,formal software verification
Entanglement measures in pilot-wave hydrodynamics (EnHydro)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France,United States
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2022-10-31
Duration (months): 36.0
Total project cost (EUR): 257619.84
EU funding (EUR): 257619.84
Participants: 2
Project status: CLOSED

A series of ground-braking experiments performed at 2005 showed that millimetric liquid drops can self-propel along the surface of a vibrating fluid bath, by virtue of a resonant interaction with their own wave field. Even more, they demonstrated a version of the famous single-particle diffraction experiment, where one droplet at a time passed through a single or a double slit. The resulting statistical behaviour for successive drops revealed the emergence of wavelike diffraction (single slit) and interference patterns (double slit), a feature previously thought to be exclusive to the microscopic quantum realm. Following investigations established hydrodynamic analogs of many more quantum phenomena with this system, including tunneling, quantized orbits, orbital level splitting, spin states, and more. As of yet, an analog of quantum entanglement remains elusive, but very recent results pave the way in that direction. EnHydro aims to establish entanglement measures in pilot-wave hydrodynamics through experiments with droplets confined to separate wells and their theoretical rationalization. Experiments to test Bell’s inequalities in this particle-wave-particle system are envisioned as well. Furthermore, physical analogies with quantum entanglement and with theories proposed to rationalize quantum phenomena at the atomic level will be investigated. The originality of this project also lies in its multidisciplinary character and the complementarity of two world-leading research groups in interrelating approaches. It combines a major experimental component using the state-of-the-art set-up available at MIT, with pioneering mathematical algorithms recently developed at ESPCI. The novelty of the proposed research is that it will extend the range of behaviours accessible to classical systems. It will demonstrate how two (otherwise) non-interacting particles (droplets) can communicate through fields of standing waves, which is an extremely novel communication protocol.

Keywords: hydrodynamic quantum analogs,bouncing drops,quantum entanglement,bell s inequalities,non linear interactions,pilot wave theory,self organization,complex systems
Innovative Enterprise Financing Ideas from Europe conference (FIE2016)

Framework: Horizon 2020 — Industrial Leadership
Programme: Access to risk finance
Action type: Coordination and support actions
Countries involved: Germany
Call: RISK FINANCE (H2020-Adhoc-2014-20, 2016)
Start date: 2016-01-23
End date: 2016-07-22
Duration (months): 6.0
Total project cost (EUR): 313176.33
EU funding (EUR): 300000.0
Participants: 1
Project status: CLOSED

Main objective of this action is to have staged an event that has, through a clear communication strategy, raised awareness of the opportunities for financing research, innovation and entrepreneurship. To have strengthened existing and built new networks contributing to an effective dissemination of information continuing after the event.

Keywords: access to risk finance,innovative enterprise,conference,presidency
Dry season P. falciparum reservoir (DrySeasonPf)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 812500.0
Participants: 2
Project status: SIGNED

The mosquito-borne Plasmodium falciparum parasite is responsible for over 200 million malaria cases and nearly half a million deaths each year among African children. Dependent on Anopheles mosquito for transmission, the parasite faces a challenge during the dry season in the regions where rain seasonality limits vector availability for several months. While malaria cases are restricted to the wet season, clinically silent P. falciparum infections can persist through the dry season and are an important reservoir for transmission. Our preliminary data provides unequivocal evidence that P. falciparum modulates its transcription during the dry season, while the host immune response seems to be minimally affected, suggesting that the parasite has the ability to adapt to a vector-free environment for long periods of time. Understanding the mechanisms which allow the parasite to remain undetectable in absence of mosquito vector, and to restart transmission in the ensuing rainy season will reveal complex interactions between P. falciparum and its host. To that end I propose to: (i) Identify the Plasmodium signalling pathway(s) and metabolic profile associated with long-term maintenance of low parasitaemias during the dry season, (ii) Determine which PfEMP1 are expressed by parasites during the dry season and how effectively they are detected by the immune system, and (iii) Investigate the kinetics of P. falciparum gametocytogenesis, its ability to transmit during the dry season, and uncover sensing molecules and mechanisms of the disappearance and return of the mosquito vector Undoubtedly, results arising from the present multidisciplinary proposal will provide novel insights into the cell biology of dry season P. falciparum parasites, will increase our understanding of their interactions with their hosts and environment. Furthermore, it may benefit the international development agenda goals to design public health strategies to fight malaria.

Keywords: malaria,plasmodium falciparium,infection reservoir,environmental sensing
Microbial Desalination for Low Energy Drinking Water (MIDES)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Innovation actions
Countries involved: Germany,Spain,Spain,Spain,Austria,Tunisia,Hungary,Netherlands,Netherlands,Netherlands,Chile,Portugal
Call: Low-energy solutions for drinking water production (H2020-NMP-2015-two-stage, 2015)
Start date: 2016-04-01
End date: 2020-09-30
Duration (months): 54.0
Total project cost (EUR): 8019583.04
EU funding (EUR): 6328164.13
Participants: 13
Project status: CLOSED

Shortage of fresh water has become one of the major challenges for societies all over the world. Water desalination offers an opportunity to significantly increase the freshwater supply for drinking, industrial use and irrigation. All current desalination technologies require significant electrical or thermal energy, with today's Reverse Osmosis (RO) desalination units consuming electric energy of at least 3 kWh/m3 – in extensive tests about ten years ago, the Affordable Desalination Collaboration (ADC) in California measured 1.6 kWh/m3 for RO power consumption on the best commercially available membranes, and total plant energy about twice as high. To overcome thermodynamical limitations of RO, which point to 1.09 kwh/m3 for seawater at 50 % recovery, Microbial Desalination Cells (MDC) concurrently treat wastewater and generate energy to achieve desalination. MDCs can produce around 1.8 kWh of bioelectricity from the handling of 1 m3 of wastewater. Such energy can be directly used to i) totally remove the salt content in seawater without external energy input, or ii) partially reduce the salinity to lower substantially the amount of energy for a subsequent desalination treatment. MIDES aims to develop the World’s largest demonstrator of an innovative and low-energy technology for drinking water production, using MDC technology either as stand-alone or as pre-treatment step for RO. The project will focus on overcoming the current limitations of MDC technology such as low desalination rate, high manufacturing cost, biofouling and scaling problems on membranes, optimization of the microbial-electrochemical process, system scaling up and economic feasibility of the technology. This will be achieved via innovation in nanostructured electrodes, antifouling membranes (using nanoparticles with biocide activity), electrochemical reactor design and optimization, microbial electrochemistry and physiology expertise, and process engineering and control.

Keywords: microbial desalination cells
Towards a responsible AI-driven transformation of work (RESP-AI) (RESP-AI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: SIGNED

While there is no doubt that artificial intelligence (AI) will bring about an unprecedented transformation of work, researchers are still hotly debating how AI will transform work. The AI-pessimists warn against massive unemployment and the risks that AI deskills and enslaves humans. The AI-optimists laud AI’s potential to improve working lives and to enable innovating as never before. Both camps seem to ignore that the future of work is still open: this future very much depends on how AI is deployed in organizations. The future of work can be bright for both organizations and workers if organizations start right now responsibly reskilling and retraining workers to collaborate with AI, unleashing the extraordinary innovative potential of this new form of collaborations while providing workers with more meaningful work. Today, there is, however, close to no scientific work to guide organizations in responsibly transforming work when adopting AI. My interdisciplinary research project addresses this urgent gap. Combining innovative and cutting-edge qualitative, quantitative, and conceptual methods, I will deliver three scientific papers and a roadmap to fulfill two broad objectives. My first objective is to provide an in-depth understanding of the state of affairs regarding the AI-driven transformation of work in multiple organizations and across multiple sectors (How is work transforming? How is this transformation affecting workers? How responsible has the transformation been so far?). Then, based on a good grasp of both organizations’ and workers’ needs linked to the AI-driven transformation of work, my second objective is to provide a roadmap to guide managers on how to transform work responsibly to unleash AI innovative potential and ensure a bright future for workers. The project is not only highly scholarly innovative, it is also highly relevant for the competiveness of EU firms and for EU workers (special attention will be paid to women).

Keywords: responsible management,artificial intelligence,future of work