Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unfolding the Mechanism of Chromosome Cohesion and Condensation using Single-Molecule Biophysical Approaches (Mechan-of-Chromo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-06-01
End date: 2021-11-30
Duration (months): 66.0
Total project cost (EUR): 1894999.0
EU funding (EUR): 1894999.0
Participants: 1
Project status: CLOSED

The global folding of the chromosome is mediated by Structural Maintenance of Chromosome (SMC) proteins, which stabilize the higher-order chromatin architecture by bringing distant DNA sequences together. Despite over a decade of work on these systems, their mechanism remains unknown, largely because of difficulty in re-capitulating physiological DNA binding and condensation in vitro. Moreover, traditional biochemical approaches are poorly suited for the study of processes that are fundamentally mechanical in nature. However, key breakthroughs, including the discovery that SMC is loaded by Spo0J protein at parS sites in vivo, and that parS sites act as global condensation centres for the chromosome have opened new possibilities to study chromosome organisation using single-molecule (SM) approaches. Importantly, our recent experiments with Magnetic Tweezers (MT) have already revealed a novel function of Spo0J in condensing DNA via a parS-independent binding mechanism. Inspired by these recent discoveries, I have devised a series of novel SM biophysical approaches with the ambitious goal of determining the mechanism of action of SMC complexes, including understanding the role of SMC loaders and SMC accessory subunits, and how these proteins are regulated by ATP binding and hydrolysis for chromosome organisation. The rationale behind this approach is that SM methods are particularly well-suited for monitoring DNA cohesion and condensation where manipulation of individual DNA molecules, measurement of forces, and addition of proteins and buffer solutions can be carefully controlled. High throughput MT will be combined with fast video imaging, optical trapping, and fluorescence; and will be used to interrogate hypothetical models for SMC-DNA interactions. Finally, the novel assays developed here may be applicable to other protein-DNA interactions including variant SMC-like proteins specialized for other biological functions such as DNA repair.

Keywords: single molecule biophysics,magnetic tweezers,optical tweezers,fluorescence,tirf microscopy,chromosome condensation and cohesion,smc proteins,scpa,scpb,spo0j,parb
Cardiac micro-engineered tissue for high-throughput screening (CAMEOS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2019-06-30
Duration (months): 36.0
Total project cost (EUR): 260929.8
EU funding (EUR): 260929.8
Participants: 3
Project status: CLOSED

Heart disease is the most significant cause of morbidity and mortality in the industrialized world, and the cause of 4 million death each year within the European Union. The prevalence of the disease is a huge burden on society estimated to cost the EU economy 60 billion annually on drug therapy, patient care, and loss in productivity. Nonetheless, despite the latest advances in research much remains to be learn about pharmacological treatments in cardiovascular disease. Recently, the development of induced-pluripotent stem cells (iPSC) technology has led to the creation of ‘patient-in-a-dish” models through the utilization of iPSC-derived cardiomyocytes. In this setting, a high-throughput screening approach can applied to find novel therapeutic interventions and detect the cardiotoxicity of drugs. However, the limitation of the current format centers on the lack of phenotypic cardiomcyoytes maturity. Consequently, these in vitro models often fail to recapitulate relevant physiological traits. The aim of CAMEOS is to develop a cardiac microtissue with superior physiological relevance for in vitro high-throughput screening. I will employ state-of-the-art cardiac tissue engineering principles to improve the maturation of iPSC-cardiomyocyte. These will be scaled-down, by the development of microtissue, for utilization in high-throughput 96-well plate format, and will be validated by their pharmacological responses and iPS-disease modeling potential. I will apply the developed microtissue to model a complex disease mutation, phospholamban (PLN) R14del, for which the pathology is poorly understood and no cure is available. In the microtissue, I will be able to study the physiological implication of the mutation and perform a high-content screens in attempt to find novel therapeutic targets.

Keywords: cardiac tissue engineering,high throughput screening,phospholamban,disease modeling,induced pluripotent stem cells,biomaterials
A silver path to a new generation of quantum materials. (SILVERPATH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

Silver(II) fluoride is a strongly correlated charge transfer insulator, with characteristics remarkably similar to those of parent high-temperature superconducting cuprates. AgF2 has the potential to be the basic building block to a new class of strongly correlated materials with fascinating properties. The purpose of SILVERPATH is to develop appropriate models to characterize and predict magnetic, metallic and superconducting properties by combining analytical and computational methods. In collaboration with leading chemistry and experimental groups silver fluorine based materials and heterostructures will be designed, possible routes to metallization explored, and their properties studied. The project will ensure large progress in understanding low-dimensional quantum magnetism and has great potential to contribute to the discovery of a new class of high-temperature superconductors. The project will give the ER the opportunity to follow all the processes in the construction of a theory for a quantum material, from the model building and parameter determination to the prediction of physical properties, putting her in a position of leadership in this class of correlated materials and ready to attack any new material in the field. Moreover, SILVERPATH will contribute to strengthen the transfer of knowledge between condensed matter physics and chemistry communities.

Keywords: silver fluoride materials,material engineering and design,non linear optical properties,high tc superconductivity,cuprate analogues,spin peierls
Smart multilevel Power conditioning for AeRonautical elecTricAl uNits (SPARTAN)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain,Poland
Call: Intelligent Power Module (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-11-01
End date: 2022-04-30
Duration (months): 42.0
Total project cost (EUR): 744634.19
EU funding (EUR): 587637.33
Participants: 5
Project status: SIGNED

This proposal aims to develop and demonstrate a highly robust and reliable Intelligent Power Modules (IPMs) for the power conditioning of multiple electrical sources, optimall integrated into the electrical power generation system of the aircraft. Specific objectives are listed as follows: • Development of high performance and efficiency IPMs with a minimum impact on the size and weigth of the systems. This objective includes a design based on the most adequate topology based on advanced multilevel and interleaved topologies allowing a minimization of the passive components in terms of size and weight. • Achieve a high performance based on the use of high-efficiency wide bandgap semiconductors and its integration in the most suitable multilevel topology, at the same time that minimum size and weight are pursued. • High reliability and robustness based on a modular multilevel approach which removes the affected module in case of failure avoiding an interruption of the operation and permiting the operation with a degraded performance. • Achievement a high modularity and scalability with a high percentage of common design of the AC/DC and DC/DC modules, optimizing thus the integration of both power stages, the manufacting process and the Mean Time Between Repair. • Providing a full controllability of both power stages to higher hierarchical controller based on an advanced hardware/software architecture scheme with a multi-core approach (FPGA + DSP+ARM) that fully control each power module with a high bandwidth capacity. The developed control electronics includes advanced features that includes protection and failure management functions for a primary and fast response and the possibility for implementing autonomous and/or emergency strategies • Development of a specific modulation to obtain the highest performance of the proposed topology, optimizing the desired parameters (efficiency, losses, …)

Keywords: modular multilevel converter,interleaving,wide bandgap semiconductors,fault tolerant,modularity
Smart Energy Management and Strategic Decision Making Platform (W-THINK)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The way industries manage and consume energy is currently unsustainable. Today the industrial sector accounts for onethird of world energy use and industrial energy consumption is set to rise by 50% in just 20 years. On average, an industry spends one-third of its operating budget on energy. This drastically increases electricity bills while reducing productivity. Up to 35% of total industrial energy, or 110€ billion could be saved every year, just through the application of energy-saving and low carbon practices. Heating, Ventilation and Air Conditioning (HVAC) is responsible for around 40% of the energy consumption in industrial plants. Frequently, this is the largest energy consuming type of equipment on a site and can therefore provide significant scope for saving energy and money. W-THINK is an Industrial Energy Management System (IEMS) Software as a Service (SaaS) that optimizes and reduces energy consumption of HVAC and superheated water using state of the art Industrial Internet of Things (IoT), Big Data and machine learning algorithms. W-THINK collects the basic data from around the variety of sensors around the plant, analyses this data and compares it to external data, such as future weather patterns, takes control of the plant’s systems for HVAC and superheated water, and optimizes their performance to ensure optimal use of energy. This is all done automatically and in real time. Furthermore, as this software is hardware neutral and easily customisable to meet users’ needs, it is a cost effective solution for any scale and type of industrial plant. The aim of our project is to make W-THINK available to be used by all types of industries in Europe and worldwide. The IEMS market is set to from 12.3€ billion in 2015 to 32€ billion in 2024, and achieving our projections will provide an estimated overall profit of 9,7M€ within 5 years after the project ending, a return of 550%.

Keywords: industrial energy,management system,automated software,big data,reduced emissions
Deaf Smart Space (DSS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-08-01
End date: 2019-05-31
Duration (months): 22.0
Total project cost (EUR): 1969803.85
EU funding (EUR): 1343900.0
Participants: 1
Project status: CLOSED

Deaf people encounter several major obstacles that prevent them from seamlessly integrating in society and exclude them from many ICT services that a hearing person simply takes for granted. Hence, our trans-disciplinary team of hearing and deaf, started to develop ICT hardware, services and a smartphone App, which enable people with hearing deficiencies to more seamlessly interact with their environment. While our App is not at TRL 9, we plan to bring our innovations Deaf Smart Space-Home (DSS-Home) and Deaf Smart Space-Places (DSS-Places) to market within SME Instrument Phase 2. Deaf Smart Space-Home (DSS-Home), at TRL 7, provides accessibility in private homes, while Deaf Smart Space-Places (DSS-Places) at TRL 6 provides accessibility in public buildings such as administrative buildings, airports, train stations, hotels, museums, and shopping malls. According to the World Health Organization, partial hearing loss affects 360 million worldwide and is likely to grow to 1 billion over the next couple of years. This, paired with advanced signal processing and IoT technology becoming cheaper and therefore more accessible to a large share of the population, paves the ground for our open disruptive Deaf Smart Space innovation. We have 10143 App users from 142 countries, pre-sold 348 DSS-Homes, and have 25 DSS-Places waiting to be installed. Further, a cooperation agreement has been signed with Spain’s leading tele-assistance provider, Atenzia, to roll out DSS service to 100 000 households, while the President of Telefonica, as well as the General Director of the Vodafone Foundation expressed their interest to become DSS roll-out partners. By the end of 2019, we aim to acquire 3.5%, 0.08% and 0.075% of the addressable hard hearing market in Spain, Europe and the US, respectively. This corresponds to hardware sales of 24.9M €, services charges of 1.3M €, 86 direct jobs created (30 of them for deaf), plus 81 indirect jobs created at our service and production partner.

Keywords: smartphone app,mobile applications,hearing impaired,pre lingual,sign language,cochlear implants,social for profit,internet of things
Find Your Passion for Science on Researchers Night (FUSION NIGHT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Poland
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-06-01
End date: 2015-11-30
Duration (months): 18.0
Total project cost (EUR): 81000.0
EU funding (EUR): 81000.0
Participants: 2
Project status: CLOSED

Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences (IAR&FR), in partnership with Olsztyn School of Higher Education (OSHE) invites kids, tweens, teens and adults to join FUSION Researchers’ Night – a unique occasion when science, entertainment and education meet in one place! Fusion Night is an incredible blend of research, innovation, fun and education that introduces young people to meet scientists who live in their city but whose work reaches across the whole world. The FUSION Night (FN) programmes revolves around the activities that will increase the awareness of the community at large about the importance of research careers and the central role of scientists in improving the daily life and well-being of European citizens. Visitors of the FN will have a chance to join edutaining activities, become a researcher for one night and give lecture to their peers (Polish Academy of Kids), test the content of vitamins in juice or milk (“Vitamins fusion or health illusion?), discover the secrets of cryopreservation in a mobile laboratory (“Ice land”), develop their own creams using fruit powders (“Tasty skin”), design a book from scratch (“Night in the Library”), learn the secrets of animal biodiversity (“Take a walk on the wide side”) or make a fruit puree in liquid nitrogen (“Molecular Show of Fusion Kitchen”). Sport enthusiasts can expect swimming competitions, basketball game, salsa course and martial arts training all conducted by our young researchers. We haven’t forgotten about the music and art lovers too, preparing for them a live concert of an international group of English teachers and an exhibition of science curiosities captured on the stained glass. Collaboration with partners from industrial circles will help to provide visitors with a first-hand view of the products and innovations “born” thanks to the solutions provided by science and researchers.

Keywords: impactof science on daily life,edutaining activities,young people,fascinating research careers,innovation,connecting researchers with the public,life sciences
Unravelling the mechanism of nuclear transport using optical nanopores (NTON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: SIGNED

The nuclear pore complex (NPC) is the gatekeeper of the nucleus that regulates the flow of all molecules across the nuclear envelope. Remarkably, this ~40 nm wide pore is capable of efficient and fast transport while remaining highly selective. Its dense central channel is composed of a highly dynamic spaghetti-like mesh of intrinsically disordered proteins that allows small molecules to pass freely, whereas large macromolecules (>40 kDa) rely on specific transporter proteins that ferry their cargo across the pore. Even though various models have been proposed, the fundamental biophysical mechanism of nuclear transport and of the selectivity of the NPC has not been resolved yet. One of the main reasons that have hindered our progress in understanding nuclear transport is the lack of experimental techniques that can probe the structure and dynamics of the disordered proteins and transport receptors inside the NPC channel and during transport with sufficient spatiotemporal resolution. In the proposed action, I aim to establish a modifiable biomimetic platform for single-molecule investigations of nuclear transport. This interdisciplinary and innovative approach combines solid-state nanopores, coated with disordered proteins to mimic the nuclear pore, with optical detection in zero-mode waveguides and DNA origami nanotechnology. The proposed experiments will allow to monitor the translocation of single fluorescently labelled molecules through biomimetic NPCs with excellent sensitivity and specificity. I will use this platform to elucidate the biophysical principles that underlie the structure and selectivity of the NPC channel and the mechanism of active nuclear transport. The direct insights on the single-molecule level obtained by the results of this project will be crucial for our understanding of the molecular principles that govern nuclear transport.

Keywords: nanopores,single molecule,fluorescence,fret,intrinsic disorder,fluorescence spectroscopy
Efficient and Low CO2 footprint B2B turnkey LED module with an innovative thermal solution (ECOLED)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Belgium
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

LED lighting is increasingly a part of our daily life, thanks to its proven advantage in energy saving and longer lifespan. Nevertheless thermal management of LED lighting fixtures remain an issue like other electronic devices (e.g. laptops, smart phones). ECOLED is solving this problem thanks to its patented IF-T LED technology. The aluminium content of ECOLED is up to 75% lower compared to current LED modules. This leads to a smaller, embeddable, longer lasting and even more energy saving light source. A first generation of ECOLED will appeal to clients to take advantage of size and the ease of a pre-assembled device. This is the market segment of indoor design lighting fixtures. The second generation ECOLED will play out the temperature management functionality creating a device that has a considerably longer lifespan. This advantage will have a disruptive effect for clients in the segment of residential, office, industrial and outdoor lighting, a €2,5 billion market in Europe alone. Beside the abovementioned characteristics, ECOLED has two other important long term and sustainable advantages. In the first place, lower aluminium content and energy saving lead to an unseen eco-friendliness. The ecological footprint of the ECOLED module will be half of the size of a conventional LED solution. 1 million ECOLED lighting sources save 4,7 million ton CO2e, only thanks to lower aluminium content. The reduction of GHG emissions is completely in line with the mission of the company behind the technology, SustainableLedLighting (SLL), to create sustainable ecological advantages thanks to technological improvements in the lighting business. In the second place, SLL’s business strategy offering a turnkey solution through tailor made sourcing and assembly keeps a big part of the value chain in Europe where the lighting sector - mostly SMEs – gives employment to 150.000 Europeans.

Keywords: sustainablity led lighting