Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Feasibility study: Cloud-based diagnostic software for infectious diseases (BACRES)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Sweden
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The problem of antibiotic resistance is considered one of the largest threats to human health by the World Health Organization (WHO). In EU and the US antibiotic resistance infections have been estimated to cause > 48 000 deaths from 2,5 million resistant infections and confer an excess direct healthcare cost of € 20 billion annually. A major contributor to this is current diagnostic methods, being slow (longer than 48 hours), resource-consuming and/or non comprehensive resulting in ineffective treatment. 1928 Diagnostics is developing a software solution that takes advantage of modern DNA technology (next generation sequencing, NGS) that is currently not used in clinical routine due to complex data analysis that is time and recourse intensive. Our solution is a software-as-a-service that combines cloud computing and a proprietary bioinformatics platform that automatically processes large and complex data to give resistance profiles as well as bacterial identification in just 15 minutes, enabling complete diagnosis in under 12 hours. The only thing required at the hospital laboratory is an internet connection in order to upload NGS raw data and to download the resistance profiles that will be used as a decision support for the doctor in the treatment selection for a particular patient. The result is shortened time from patient sampling to treatment, resulting in reduced mortality, less transmission of resistant bacteria and diminished costs for the health care system and society. Our product addresses a market that is worth over € 8 BN based on 55 million potential tests in EU and US. The feasibility study will focus on understanding the customers and market demands for the first version of the product in order to reach the market in the most efficient way. In a following Phase 2 project activities will include product development, clinical validation studies and CE marking activities to support product launch in 2017.

Keywords: antibiotic resistance diagnostic software bioinformatics sequencing
Perpetual Sensing in Harsh Environments: Self-powered sensors for the Oil Gas industry (HarshEnergy)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Portugal
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-29
End date: 2018-09-28
Duration (months): 12.0
Total project cost (EUR): 86692.5
EU funding (EUR): 86692.5
Participants: 1
Project status: CLOSED

The main objectives of this proposal are the prototyping, testing and implementation of new energy harvesting systems based on nanomaterials able to operate in harsh environments (temperatures above 250 ºC and pressures of 10000 psi), particularly relevant for the oil & gas industry. inanoEnergy is a startup company aiming to develop and fabricate innovative products in the field of energy harvesting using high efficiency nanogenerators and that was recently awarded an ESA BIC project from the European Space Agency. Based on inanoEnergy proprietary technology one seeks to develop innovative solutions to harvest energy to power sensor networks in harsh environments. Using the hybridization of three different energy harvesting technologies (piezoelectricity, triboelectricity and electromagnetic induction) we will optimize prototypes to be implemented inside or around pipes or in a side pocket configuration. The use of complementary energy harvesting technologies in a single devices makes their hybridization and integration in a single project an added value. However, Portugal lacks the human resources with the specialized skills needed to develop the proposed solution. Thus, the possibility to recruit an innovation associate at the European level would be a tremendous benefit for the development of this project and the future prospects of our startup.

Keywords: energy harvesting,internet of thing,sensors
Unique machine to produce a revolutionary RFID TAG (SNAPTAG)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2017-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Current identification technologies have several limitations. Bar codes need to orient each item towards a reader. Current inlay tags and coupled tags are expensive, too thick for imbedding applications, and polluting due its manufacturing process and its disposal based on PET slips small to recycle. Common problem is their low reading accuracy, and long & expensive projects needed to redesign new RFID antenna. Currently there is no cost-effective RFID manufacturing machine neither optimised tag solution. To overcome those limitations, FABELE Srl., Italian company of 20-years expertise in RFID technology, developed & manufactured a breakthrough in RFID devices, SNAPTAG machine & Zorro tag. SNAPTAG is the first office machine to manufacture, in the easiest & most competitive way, innovative smart RFID Zorro tags, for new applications. SNAPTAG allows a cost-effective tag production, 78.000 €/unit, compared to traditional equipment for tags labelling & encoding (up to 1M €/unit); low operation cost (0,01 €/tag); strong economic benefits saving up to 55% of tags expenditure; short payback period: 12-24 weeks; unattended production (easy to operate); and reliable performance test on-production line. Zorro tag design allows to correct detuning effect, multiple tag reading up to > 20 m distance in a wide range of frequencies (UHF: 860-960 MHz). It has an unmatchable adaptability & flexibility for immediate prototyping thanks to the fast and low-cost modification of the antenna dimension.; it is cheaper & disposable: 0,03€/unit; and is a green tag supported on biodegradable paper. SNAPTAP successful launch will be by 2020, and after 5 years we will sell 208 SNAPTAG units, 888M antenna units, and RFID consultancy services, that will be worth 47,25 M€, with an accumulative profit of 14,5M€. We already collaborate with key stakeholders: Mecstar, Walki, DPR, Kereon Solutions, Voyantic and Cisc, who gave 6 support letters.

Keywords: rfid,tgas,inlay,rfid antenna,production process,detuning effects
Beta Cell Generation by Stem Cell-Derived Implants in Diabetes (BetaCellTherapy)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Italy,Belgium,Switzerland,France,Netherlands,United States
Call: Clinical research on regenerative medicine (H2020-PHC-2015-single-stage_RTD, 2015)
Start date: 2015-12-01
End date: 2022-08-31
Duration (months): 81.0
Total project cost (EUR): 6800000.0
EU funding (EUR): 6200000.0
Participants: 9
Project status: SIGNED

Despite improved treatment, diabetes remains a chronic disease with major health risks and heavy burden on patients and society. Serious forms are caused by depletion in pancreatic beta cells and associated loss in insulin’s homeostatic control throughout life. Their cure requires restoration of a metabolically adequate beta cell mass. Implants of beta cell grafts prepared from human pancreases have shown proof-of-principle but also the need for developing a large-scale source for therapeutic cells. Our objective is to generate a functional beta cell mass by stem cell-derived implants in diabetes patients. A combined preclinical and clinical project will search recipient and implant conditions for formation and maturation of beta cells in subcutaneous implants of device-encapsulated pancreatic endodermal cells that are derived from human embryonic stem cells (hu-ES) and manufactured for clinical studies. We collected preclinical evidence for the therapeutic potential of this implant from comparison with clinically used human beta cell grafts. State-of-the art methods and markers have been developed to investigate the biology of implants and to monitor host immune and innate reactivity. This approach helps understand the basis for metabolic outcome and identify targets for improvement. Pilot studies examine the influence of the (auto)immune status of the patients. Data will determine transition to clinical efficacy studies, or indicate the need for further laboratory development. Implants in preclinical models will guide modifications in clinical protocols, and explore the biologic properties of grafts derived from human induced pluripotent stem cell (iPSc) as can also be prepared from diabetes patients. Our consortium joins innovating cells, methods, markers and minds in a unique combination of expert clinical, academic and industry activities that need each other to make progress in an ambitious program.

Keywords: type 1 diabetes,cell therapy,beta cell replacement,insulin,hu es cells,hu ips cells,biomarkers,encapsulation device,preclinical models
The geometry of modular representations of reductive algebraic groups (ModRed)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France,France
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2021-08-31
Duration (months): 60.0
Total project cost (EUR): 882843.75
EU funding (EUR): 710718.75
Participants: 4
Project status: CLOSED

The main theme of this proposal is the Geometric Representation Theory of reductive algebraic groups over algebraically closed fields of positive characteristic. Our primary goal is to obtain character formulas for simple and for indecomposable tilting representations of such groups, by developing a geometric framework for their categories of representations. Obtaining such formulas has been one of the main problems in this area since the 1980's. A program outlined by G. Lusztig in the 1990's has lead to a formula for the characters of simple representations in the case the characteristic of the base field is bigger than an explicit but huge bound. A recent breakthrough due to G. Williamson has shown that this formula cannot hold for smaller characteristics, however. Nothing is known about characters of tilting modules in general (except for a conjectural formula for some characters, due to Andersen). Our main tools include a new perspective on Soergel bimodules offered by the study of parity sheaves (introduced by Juteau-Mautner-Williamson) and a diagrammatic presentation of their category (due to Elias-Williamson).

Keywords: reductive algebraic groups,representation theory,perverse sheaves,characters,soergel bimodules,koszul duality
Ecological Utilization of Waste (EUWaste)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Ukraine
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

On average one person in Europe uses 16 tonnes of material per year, of which 6 tonnes become waste. In 2010, total waste production in the EU amounted to 2,5 billion tons. From this total only a limited (albeit increasing) share (36%) was recycled, with the rest was landfilled or burned, of which some 600 million tons could be recycled or reused. From total amount 100 million tonnes is hazardous, containing heavy metals and other toxins. These substances make the waste particularly difficult to treat, as special processes are needed to deal with the hazardous components. Our Firm “Institute of Human Ecology-INEKO” (INEKO) developed an innovative solution that offers elegant and cost effective solution to utilization problem of hazardous waste, such as hazardous health care waste, oil-contaminated waste, pesticides, solid and liquid waste and sludge containing hazardous substances, and other kinds of waste (agricultural waste, unsorted municipal solid waste, etc.) EUWaste uses technology of gasification that allows utilizing waste of different type with a minimum environmental footprint and emission. Moreover, the use of gasification technology allows obtaining synthetic gas during the gasification process, which in turn can be used as a source of alternative energy for heat production. By using EUWaste, waste producers (e.g. health care facilities, pharmaceutical companies, petrochemical factories, etc.) and waste utilizers can improve their waste management and help to reduce health and environmental problems, reduce greenhouse gas emissions and avoid negative impacts at local level such as landscape deterioration due to landfilling, local water and air pollution, as well as littering. The objective of the EUWaste project is to conduct a feasibility study, which includes market analysis, production scale-up and business model and sales strategy development), first focusing on the medical waste utilization and further on other potential segments of waste management

Keywords: gasification,zero emission,health care waste,waste to energy,waste management,medical waste utilization
An Eco-Innovative Alternative to Plywood (ECOSHEET-PRO)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy,United Kingdom
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-06-01
End date: 2019-12-31
Duration (months): 31.0
Total project cost (EUR): 3183977.5
EU funding (EUR): 2228784.25
Participants: 2
Project status: CLOSED

ECOSHEET-PRO is an eco-innovative and cost effective alternative to plywood made from mixed plastic waste, suitable for high strength applications in the construction industry. This project will tackle two significant environmental challenges facing Europe, whilst also offering added value to the construction industry. The first issue addressed is that of mixed plastic waste. In Europe, in 2014, 18 million tonnes of post-consumer waste plastics were landfilled or incinerated, as they could not be easily separated and recycled. Alternative uses for such waste must be found. The second issue is the growth in the use of plywood, typically manufactured from slow-growing, tropical hardwoods. This material is a key, high volume commodity in construction industry formworks and an area the size of Madrid is deforested each year to meet Europe’s demand. ECOSHEET-PRO transforms mixed plastic that would otherwise be wasted into a competitive, reusable, plywood replacement. Previous attempts to create such boards have failed to deliver the required strength or cost effectiveness required by industry. We have overcome these barriers through an innovative manufacturing process, which will be scaled up and refined during this project. ECOSHEET-PRO has the potential to re-define the €1.8 billion European plywood industry and help Europe meet its demanding plastic recycling targets, contributing to the circular economy. Our success stems from bringing together the complementary expertise of two eco-innovative SMEs from Italy and the UK, both with a strong ambition to grow and internationalise. Across a network of 13 facilities in 2023, ECOSHEET-PRO will create 77 jobs, generate annual revenues of over €76.5 million, annual profits of €26.8 million, and transform >221,000 tonnes of waste into valuable products.

Keywords: mixed waste plastics,recycling,eco innovation,feedstock preparation,extrusion,construction,formworks
REconstruction of cliMAte and hidden biodiversity in lakes: development of INnovative paleoaproacheS (REMAINS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2023-11-03
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: SIGNED

Increase of temperature and biodiversity loss are major threats in the early warning systems of the planet, the high-altitude ecosystems. The analysis of sediment records provides evidence on past response of species to climatic changes, offering a unique framework to anticipate/expand our ability to manage these ecosystems. Among the commonly used paleoindicators, the analysis of cladoceran subfossils has relied on classical morphological counting. However, recent advances in mass-spectrometry, which now need much lower sample sizes, and in molecular biology, with the use of sedimentary DNA, offer unprecedented opportunities to develop innovative approaches based on these REMAINS. The main goal of this project is to provide new advances to i) use cladoceran chitin as a paleothermometer and ii) establish a standard methodology to use their DNA in sediments. The intellectual merits of this proposal are threefold. First, it will use cutting-edge technology to measure subfossil chitin in lab assays, in situ calibration and validation phases. Second, it will address a new biological group not previously studied in ancient DNA. Last, by establishing new analytical methods for a very common component of lake sediments, the project will open up a new field in Paleolimnology and highlight how much hitherto untapped information is stored in paleorecords. The research approach will involve (i) the quantification of contribution of water-diet to H and O isotopes in chitin (ii) the field calibration between isotopic composition of chitin and temperature (iii) the paleothermometer validation in the sediment (iv) the establishment of a library of cladocerans by a genome skimming and (v) the development of a specific assay to identify them in sedimentary DNA. Framed in the “Environment & Climate Action” area from HORIZON 2020, the project addresses gaps in the knowledge needed to understand past changes and to protect natural resources, illustrated here by Sierra Nevada Mountains

Keywords: cladocerans,stable isotopes,chitin,sedimentary dna,temperature reconstruction,biodiversity,global change
4-IN THE LUNG RUN: towards INdividually tailored INvitations, screening INtervals, and INtegrated co-morbidity reducing strategies in lung cancer screening (4-IN THE LUNG RUN)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Preventing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Italy,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Towards risk-based screening strategies for non-communicable diseases (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 7999948.75
EU funding (EUR): 7999948.75
Participants: 10
Project status: SIGNED

With 338,000 EU-deaths annually, lung cancer is a devastating problem. CT screening has the potential to prevent ten-thousands of lung cancer deaths annually. The positive results of the Dutch-Belgian screening trial (NELSON), with relatively low referral rates, and the NLST in the USA provided conclusive evidence. However, implementation is likely to be limited, slow and of variable quality throughout Europe, and current guidelines could easily require up to 25 million CT screens annually. The most optimal strategy in risk-based lung-thoracic screening is still unknown regarding the optimal and most cost-effective (e.g., targeted) strategy 1) to recruit, 2) to integrate smoking cessation and co-morbidity-reducing services, and 3) to determine the (risk-based) screening interval. Personalised regimens based on the baseline CT result can potentially retain 85% of the mortality reduction achievable through screening at 45% less screens, thus potentially saving much unnecessary harm associated with screening, and 0.5-1 billion Euros per year. The heart of 4-IN-THE-LUNG-RUN is a randomised controlled trial amongst 24,000 individuals evaluating whether it is safe to have risk-based less intensive screening intervals after a negative baseline CT. Various methods to improve participation of hard-to-reach individuals will be assessed in five different healthcare settings. Innovative co-morbidity reducing strategies will be tested including other markers on CT imaging, as Calcium Score and COPD. Cost impact and cost-effectiveness analyses using a natural history model will steer implementation. The experienced consortium will strongly interact with key stakeholders, and discuss interim results with key other international initiatives on CT screening, biomarkers, and smoking cessation practices. This proposal will form the evidence base for risk-based lung cancer screening with huge benefits for the EU, on health outcomes, cost savings, and innovation in the long run.

Keywords: lung cancer,risk based screening,smoking cessation,personalised medicine,recruitment,strategy,advanced ct imaging,biomarkers