Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MOLECULAR STRATEGIES AGAINST VIRAL ENTRY AND GLYCAN SHIELDING (SHIELD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Germany,Netherlands,Portugal,Sweden,France,Denmark,Poland,Switzerland
Call: Pandemic preparedness and response: Host-pathogen interactions of infectious diseases with epidemic potential (HORIZON-HLTH-2024-DISEASE-08, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 7978165.75
EU funding (EUR): 7978165.75
Participants: 10
Project status: SIGNED

The SHIELD consortium targets two closely related steps in the viral replication cycle that are, as yet, difficult to study and to exploit for therapeutic interventions: 1) Virion glycosylation in the context of uptake, maturation and viral immunity. 2) Virion dynamics of entry into cells, where the plasticity of the involved proteins and their glycosylation status have key roles. The viruses studied in SHIELD are from the genera of flavivirus (DENV, WNV, YFV, Zika), mammarenaviruses (LASV) and henipaviruses (Hendra, Nipah). We bring a broad spectrum of methodical expertise to understand and exploit the interrelated processes of viral glycosylation and viral dynamics. Molecular simulations will enable the identification of cryptic pockets in viral proteins that form during the entry process, and the design of inhibitory ligands that bind to such pockets. Theoretical methods will be used to identify ligands for glycosylated viral proteins. This is intertwined with cryo-EM and nano-resolution optical microscopy which enable a detailed analysis of these events, their sensitivity to biological and chemical interference, and will allow a rational optimization of specificity and affinity. Novel chemical and biological entities (NCEs, NBEs) as tool compounds and potential starting points for drug development are obtained by targeted chemical synthesis, X-ray fragment screening, and nanobody library screens. Additionally, we study biological processes and the influence of interactions in systems of increasing complexity, which range from biochemical in-vitro to cellular assays and in vivo animal models. As the ‘glycan shield’ in Lassa/Hendra/Nipah plays a major role in immune evasion, we explore the immunological effects of an interference with protein glycosylation leading to novel starting point towards the development of effective and robust vaccines. In conclusion, SHIELD delivers a deeper understanding, and molecular tools to prepare the EU for future pandemic events.

Keywords: glycosylation,viral entry,virion dynamics,flavivirus,mammarenaviruses,lassa,zika,yellow fever,henipaviruses,hendra,nipah
Physics-informed Data-driven Analysis for Wind Power Hubs (PhyDAWN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark,Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 2
Project status: SIGNED

To address the challenges of climate change and energy crisis, the European Union (EU) is accelerating the transition to carbon neutrality, using wind power as the key driver. To fully exploit EU’s offshore wind resources, the strategy of constructing wind power hub has been devised recently and will be implemented in the North Sea. However, integration of numerous power converters in wind power hub forms a sophisticated system, making analysis difficult. This project (PhyDAWN) will tackle these challenges by developing physics-informed data-driven modelling and stability assessment methodologies for wind power hub. Firstly, effective impedance model of voltage source converters for varying operation points will be developed based on physics-informed machine learning. Next, a scalable aggregated model for wind power hub will be proposed using transfer learning, improving modelling effectiveness under insufficient data. Then, the stability of wind power hub will be assessed in a probabilistic manner, realizing intensive stability analysis for internal converters. A software toolbox will also be developed for fully exploitation of the research results in the industry. The applicant has expertise in data-driven grid analysis. During the project, she will collaborate with the supervisor at Aalborg University, who has rich research experience on power converter modelling and analysis. Besides, she will collaborate with the secondment supervisor at KTH Royal Institute of Technology, who is an expert of control theory. Through these collaborations, PhyDAWN will create novel knowledge for wind power hubs, and also strengthen the applicant’s career prospects. The research results will be disseminated by publications in top journals and conferences, producing a positive impact on raising the Europe knowledge base. Moreover, communication activities are planned to expand the impact of this project to the general public, committing to EU’s carbon neutrality ambition.

Keywords: power converters,power electronics,wind power hub,modelling and stability analysis,data driven approach
Governing Quakerty in a Post-Disaster Türkiye (QUAKERTY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 183600.96
EU funding (EUR): 183600.96
Participants: 1
Project status: SIGNED

This academic research, entitled 'Governing Quakerty', focuses on the intersection of 'quake' and 'property', and sheds light on property governance in a post-disaster context, particularly in and around the recently quake-affected area of Antakya, in Türkiye, where the research is focused. The central research question is: How does property governance unfold in the earthquake-affected city, and what are the governmental, communal, and individual strategies implemented to deal with land and property loss, appropriation, and the ensuing processes of re-entitlement during the reconstruction period? The research examines the dynamics of disaster property in a post-quake context, encompassing both the collapse (the process of alienation) and reconstruction (the process of re-entitlement) phases, by investigating (a) the disposal, recycling and governance of earthquake-damaged property and personal belongings within collapsed or damaged buildings; (b) the process of post-disaster property claims and strategies for re-entitlement and ownership during relief and reconstruction efforts. By examining the circulation of property along the processes of loss, recycling, reconstruction and re-entitlement in the context of a destroyed urban landscape, in conjunction with legal and institutional contexts and policies, as well as the strategies and experiences of affected individuals, this scholarly investigation will make a critical contribution to the development of an effective approach to property governance in quake-affected areas, thereby assisting resilient and inclusive post-disaster property recovery efforts.

Keywords: property,earthquake,destruction,rubble,forced displacement,land grabbing,recycling,reconstruction
Photocatalysis as Powerful Tool For Polyene Cyclizations in Supramolecular Cages (PhotoCage)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Biosynthetic polyene cycllization, where complex structures are obtained, represents an impressive example of Nature's a chemist. Organic chemists are trying to emulate the Nature to develop synthetic methodologies base on these cascades. It has been demonstrated that Photoinduced Electron Transfer (PET) can achieve this polyene cyclizations under milder conditions, as plants do during photosynthesis. In this context, fluorinated alcohols are very special solvents in organic chemistry due to their particular chemical and physical properties (e. g. strong H-bonding donor ability, low nucleophylicity). The combination of fluorinated alcohols with PET processes make this strategy unique for develop new biomimetic polyzene cyclization. To achieve PhotoCage 4 main research objectives should be implemented: (a) Design of the supramolecular cage photocatalyst and study of the interaction between them; (b) Application of the designed supramolecular cage - photocatalyst to polyene cyclizations; (c) Study of the reaction mechanims; (d) Impementation and development of an asymmetric version. The proposal also offers me a unique opportunity to develop transferable skills thanks to the courses proposed by Saarland University and Professor T. Gulder wich will be a valuable asset for continuing my academic career.
Breeding Potato Seeds to Feed the World Sustainably (SEEDS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Netherlands
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Potatoes are crucial to feed the world sustainably. They produce more nutritious food on less land and with less water than any other major food crop. Potatoes, however, face a major drawback: they only grow by clonal multiplication, which means that new potatoes generate from old potatoes specifically created as starting material (so-called ‘seed-tubers’). Over the course of the centuries, this has caused 3 main problems: reliance on pesticides, high costs, and slow processes. Solynta leads the potato breeding world with innovative hybrid potato breeding technology. In a nutshell, our company is most advanced worldwide developing potato true seeds, which use 50% less pesticides, save order of magnitudes in costs, and speed up the processes by a factor of 500. With our technology, we unlock the true potential of the potato to improve grower well-being and food security worldwide. We have already achieved TRL 7, by successfully demonstrating in 2023 potato hybrids in the fields. To reach full commercial maturity, we need to increase the yield of the plants (i.e., more seeds per plant) and the yield of the seeds (i.e., more potatoes per hectare for a given amount of seeds). This is a costly development that we plan to co-finance with the EIC Accelerator grant. The EIC Accelerator equity component will be part of a larger round of 50 M€ devoted to build up our capacity to supply the market demand once our product is mature. Our financial forecasts foresee the breakeven point in 2027, and we have the target to be a 1 Bn-revenue company by 2035. This objective is realistic: the potato starting material market is worth over 10 Bn€ today, and it will increase once that Solynta will be able to bring new varieties to the market in just two years. The environmental and societal impact of our innovation is huge: our mission it to supply the world with potato seeds that will contribute to give everyone on the planet access to sufficient, safe, nutritious, and sustainable food.

Keywords: potatoes,hybrid potato breeding,true potato seeds
Grammar Assistance Using Syntactic Structures: Fast parsing with formal grammars deployed for Spanish grammar coaching. (GAUSS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: CLOSED

Grammar Assistance Using Syntactic Structures. In the times when a human's right to a cultural identity is often at odds with the standardized requirements placed by e.g. employment systems, automatic grammar coaching serves an important purpose of advising on standard grammar varieties while not imposing social pressures typical for a traditional grammar classroom or reinforcing established social roles. Such systems already exist but most of them are for English and few of them offer meaningful instructive feedback. Furthermore, they typically rely completely on neural methods, which means they require huge computational resources which most of the world cannot afford. I propose a grammar coaching system for Spanish that relies on (i) a rich linguistic formalism capable of giving informative feedback; and (ii) a new, faster parsing algorithm which makes using this formalism practical in a real-world grammar coaching application. My approach is feasible for any language for which there is a formalized grammar and is less reliant on hugely expensive and environmentally costly neural methods (while still benefiting from them where appropriate). I thus seek to contribute to Greener AI and to address global education challenges by raising the standards of inclusivity and engagement in grammar coaching while retaining the precision of systematized linguistic knowledge.

Keywords: parsing,parsing speed,hpsg,syntax,grammar,l2,second language learning,grammar coaching
HERMES: Holistic dEcision suppoRt system for infrastructure ManagErS (HERMES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Portugal,Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 2
Project status: CLOSED

The HERMES aims at developing a “Holistic dEcision suppoRt system for infrastructure ManagErS”. HERMES faces in an original and integrated way some of the major and most urgent challenges in transportation infrastructure management, namely the need of optimizing the management of bridges at a time of growing threats and the main challenges dealing with the adoption of SHM systems: The difficulties related to the interpretation of SHM results for structural health assessment, the scarcity of sensor-equipped structures in a portfolio of bridges, and the integration of SHM data into current decision support systems. The main focus of HERMES is on hydraulic risk, i.e., related to floods/scour, which is a major source of concern for decision-makers. HERMES takes advantage of innovative and advanced modeling tools (Bayesian Networks, Digital Twins, and Artificial intelligence - AI) to assist the decision-maker in structural management under operational and exceptional conditions. Using a unified platform, which receives continuous data from the entire network (e.g., vibration-based SHM data, water level, scour depth), it integrates these data into a virtual model of the network and its critical structures, assesses the state of such structures, and provides informed and optimal risk-based management plans. HERMES will be articulated in four main activities linked to specific Working Packages: A1: Scour depth inference through Bayesian Network modelling of the bridge network; A2: Implementation of Digital Twins of the bridges in the network; A3: AI-supported structural reliability assessment; A4: Risk assessment considering direct and indirect consequences and decision making. HERMES is expected to form the base for future research developments related to the topic of bridge management. It will help the EU to achieve safer and more reliable transportation of people and goods around Europe, with immeasurable and fundamentally important macroeconomic benefits for the EU.

Keywords: bridge management system structural health monitoring hydraulic risk scour
Bio-based Energy-efficient materials and Structures for Tomorrow (BEST)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Italy,Spain,Netherlands,Brazil,Argentina,Ecuador,South Africa,United States
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 774114.29
EU funding (EUR): 726800.0
Participants: 11
Project status: SIGNED

The construction sector is one of the most energy intensive and raw-material demanding human activities and, hence, it is considered to contribute to a significant share of greenhouse gas in the atmosphere. Therefore, making the construction sector “greener” is one of the main challenges for policy makers, involved companies and the scientific community. Therefore, the Bio-based Energy-efficient materials and Structures for Tomorrow (BEST) project aims at investigating the potential of bio-based composites to realise innovative materials and elements characterised by both energy efficiency and structural capabilities. The BEST project proposal will deal with the following bio-based materials: (i) Fibres and fabrics of vegetal origin, such as fibres obtained from leaves or stems of tropical plants, as well as fabrics made out of such fibres; (ii) Bio- aggregates obtained from waste and residuals of agricultural activities; (iii) Self-healing agents for concrete and other cement-based composites; (iv) Supplementary cementitious materials obtained by incinerating organic waste. Therefore, the materials and composites considered in this project proposal are supposed to have potential to tackle the main challenges for the constructions of tomorrow: - Facing climate change phenomena, by promoting “circular economy” practices; - Reducing the amount of raw materials requested by the construction sector; - Contributing to the development of local economies, by means of recycling locally-available waste in response to global challenge. The BEST project foreseen a comprehensive methodological approach including both experimental activities and theoretical modelling, as it is intended at both advancing the fundamental knowledge in one of the emerging research topics in the field of construction and building materials and paving the way toward the marked uptake.

Keywords: building materials,concrete,recycling,natural fibers,fabrics,bio base aggregates,self healing capabilities,theoretical modelling,experimental tests,durability
Vision transformers with ferroelectric oxides (ViTFOX)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Research and Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: Greece,Korea, Republic of,Germany,Austria,Switzerland
Call: Joint call with Korea (HORIZON-JU-Chips-2024-3-RIA, 2024)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 1489199.25
EU funding (EUR): 1489199.25
Participants: 8
Project status: SIGNED

ViTFOX project develops a ferroelectric-augmented intelligent semiconductors technology to demonstrate a Vision Transformer (ViT) with superb energy efficiency of > 50 TOPS/Watt and make an impact on AI-powered edge applications. The project aims to strengthen the leading position of EU and Korea in Hafnia-based Si-compatible ferroelectric electronics pioneered in Europe (Germany) and significantly advanced by Korean researchers, members of this project. ViTFOX proposes advancements beyond the state of the art, at a TRL 4-5, in the whole value chain from materials and devices to heterogeneous and monolithic integration as well as design and simulation of the ViT circuits and systems. Three of the project objectives target the design and fabrication of the main components of the ViT, namely a Compute-in Memory demonstrator, a circuit level simulator and a hardware-software co-optimization platform with ferroelectric oxides. The platform will support two types of emerging memories, high-density 3D FeRAM developed in Korea and epitaxial Ferroelectric Tunnel Junctions developed in EU. Another set of objectives target the low voltage/low power operation of ferroelectric devices using epitaxial growth, new metal electrodes and advanced processing techniques such as atomic layer etching as well as the integration of these devices to fabricate memory arrays used in the ViT. The consortium consists of five Universities, two research organizations and one large European technology development laboratory, mobilizing all necessary expertise and infrastructure in ferroelectric and semiconductor technologies. The consortium plans to valorize the technology in two of the newly established Chips JU pilot lines on advanced integration during the project and advance it to higher TRL (> 5) after the project end to ensure manufacturability for future volume production.

Keywords: ferroelectrics,memory,neuromorphic computing,compute in memory,nanofabrication,design and simulation,heterogeneous integration,cmos,semiconductors