Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A circular and chemistry-neutral approach for recycling and recovery of battery waste feeds (RENOVATE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Italy,Türkiye,Spain,Germany
Call: New processes for upcoming recycling feeds (Batt4EU Partnership) (HORIZON-CL5-2023-D2-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 4995343.75
EU funding (EUR): 4995343.75
Participants: 13
Project status: SIGNED

The increasingly rapidly growing electric vehicles (EV) market results in higher growth rates in all the LIBs volume categories, from cradle to grave. This trend makes ever more urgent the boosting of battery recycling for several reasons, the most important ones being: i) the preservation of the environment, and ii) the development of a circular economy reducing the demand for virgin materials and the Europe’s dependence from third countries. All these crucial aspects need to be handled through the development of new recycling and re-use concepts, fostering demonstrable effects in terms of efficiency and sustainability. RENOVATE aims at developing and demonstrating new circular economy solutions for the European battery value-chain, targeting the re-use of 100% of in-specification cell fractions (e.g. metallic foil, graphite, electrolyte, fluorinated compounds and cathode active materials) within the battery value chain, fostering a closed-loop circular approach that can reduce battery material waste going to landfill, increase the availability of battery precursors in the European battery eco-system, and demonstrate new added-value business cases for recyclers and battery materials users. All recycled materials will be recovered over all potential streams (pre-customer scraps and End-of-Life products). The ultimate goal is to support the green and digital transformation of the European battery industry to increase its competitiveness and promote its just growth path. Holistic, flexible, and closed-loop processes for the recycling of EoL batteries based on both low and high energy density chemistries will be designed and validated to allow real and easily implementable “net zero carbon” process. A specific aim will also be smart re-integration of the side streams (e.g. waste chemicals/solvents) in the recycling processes and/or in in other industrial activities to minimize the residues coming from batteries production.

Keywords: batteries,recycling,lib,lfp,circular economy,safety,electric vehicles
smart and multiFunctional 3D printable prO-Regenerative biologiCal matrix modulating mEchanotRansduction as advancEd theraPy to treAt skIn chRonic wounds (FORCE REPAIR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Austria,Czechia,Denmark,France,Croatia
Call: Smart and multifunctional biomaterials for health innovations (RIA) (HORIZON-CL4-2022-RESILIENCE-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 5083466.25
EU funding (EUR): 5083466.0
Participants: 18
Project status: SIGNED

Due to population lifestyle changes, i.e. obesity, diabetes and aging population, chronic wounds (CW) which fail to follow the typical healing process is a major medical socioeconomic challenge. Current wound management is clearly insufficient and advanced therapies failed in keeping their promise of reliable skin regeneration. The aim of FORCE REPAIR is to develop a smart and multifunctional wound dressing providing pro-regenerative environment and mechanical stability to treat CW. Thus, FORCE REPAIR will combine state-of-the-art technologies in a biological scaffold tailored to patient’s needs: (1) Antibacterial and bioadhesive bioink with antibiotics and anti-inflammatory loaded nanocapsules, (2) Elastin like polypeptides promoting innervation and vascularization (3) Wharton Gel Complex preventing oxidative stress and boosting key extracellular matrix proteins. Also, the dressing activated by UV light will induce contractile force to help wound closure and activate skin regeneration. A customized 3D bioprinter with a user-friendly 3D trajectory software will help to strategically placed the biological compounds to timely address and mitigate the degenerative process occurring in CW, i.e. infection, inflammation, tension forces to promote skin regeneration. The 3D printed dressing will be tested in relevant in vitro model with a human exudate library and testing relevant key healing steps (i.e. re-epithelization, angiogenesis, cell proliferation…). Selected candidates will be tested in vivo on pig CW models and mice with bacterial infection. To ensure translation to clinical practice and reach patients, regulatory framework, HTA and a business model will be defined for a viable exploitation strategy that will decrease economic burden of wound care management and improve patients’ QoL. Finally, to ensure market acceptance health professional will guide the development of FORCE REPAIR to offer a dressing that treat efficiently CW and can be used by medical staff.

Keywords: chronic wounds,tissue regeneration,multifunctional biomaterials,medical device,health economics,wound care management
Excellence Hub for Advancing Innovation in Gene Therapy (GeneH)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Life Sciences
Countries involved: Portugal,Slovenia
Call: Excellence Hubs (HORIZON-WIDERA-2023-ACCESS-07, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 4885375.0
EU funding (EUR): 4885375.0
Participants: 13
Project status: SIGNED

GeneH proposes to create an excellence hub in gene therapy through strategic partnerships within and beyond Widening countries. Despite gene therapy's recognized priority in genomic medicine and its potential for high-curative economic impact, challenges persist in its development process, from conceptualization to commercialization. GeneH intends to address these challenges by serving as a catalyst for overcoming barriers and expediting research translation. To achieve this, GeneH will establish a robust and sustainable hub that builds upon already established ecosystems in the field and recent H2020 WIDENING projects to implement centers of excellence in gene therapy (GeneT in PT and CTGCT in SL). The academic partners at its core, namely, the University of Coimbra (UC) in Portugal and the National Institute of Chemistry (KI/NIC) in Slovenia , have reached substantial achievements by partnering with industry (Bluepharma, Biocant Park, Biosistemika, Jafral), hospitals (CHUC EPE), policy makers (CCDRC, RRA LUR), ecosystem/innovation supporters (SIH EEIG, IPN), and patient associations (APAHE, ZOPS). Partners in the two ecosystems share a common goal: treating life-threatening or chronically debilitating diseases considered incurable. By harnessing the combined expertise and resources of its partners, GeneH aims to drive cross-sectoral collaboration through its 4-helix network, in a multidimensional approach that will gather further investment, address ethical and regulatory aspects, implement de-risking approaches, educational and training programes, joint R&I programs, and prepare the path for clinical trials of new gene therapy products, while actively engaging society. By positioning itself as a leading hub in gene therapy, in line with regional, national, and European strategies, GeneH seeks to contribute to European competitive leadership globally, advancing healthcare, fostering economic growth, and making a positive societal impact.

Keywords: gene therapy quadruple helix based innovation higher education advanced training randi ecossystems academia industry linkages
Human collaboration with AI agents in national health governance: organizational circumstances under which data analysts and medical experts follow or deviate from AI. (Health-AI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1499961.0
EU funding (EUR): 1499961.0
Participants: 1
Project status: SIGNED

This project will study a multi-sited ethnography of a currently evolving revolution in global health systems: big data/AI-informed national health governance. With health data being considered countries’ ‘future oil’, public and scholarly concerns about ‘algorithmic ethics’ rise. Research has long shown that datasets in AI (re)produce social biases, discriminate and limit personal autonomy. This literature, however, has merely focused on AI design and institutional frameworks, examining the subject through legal, technocratic and philosophical perspectives, whilst overlooking the socio-cultural context in which big data and AI systems are embedded, most particularly organizations in which human agents collaborate with AI. This is problematic, as frameworks for ‘ethical AI’ currently consider human oversight crucial, assuming that humans will correct or resist AI when needed; while empirical evidence for this assumption is extremely thin. Very little is known about when and why people intervene or resist AI. Research done consists of single, mostly Western studies, making it impossible to generalize findings. The innovative force of our research is fourfold: 1) To empirically analyze decisive moments in which data-analysts follow or deviate AI: moments deeply impacting national health policies and individual human lives. 2) To do research in six national settings with various governmental frameworks and in different organizational contexts, enabling us to contrast findings, eventually leading to a theory on the contextual, organizational factors underlying ethical AI. 3) To use innovative anthropological methods of future-scenarioing, which will enrich the anthropological discipline by developing and finetuning future-focused research. 4) The research connects anthropological insights with the expertise of AI-developers, and partners with relevant health decisionmakers and policy-institutions, allowing to both analyze and contribute to fair AI.

Keywords: human nonhuman collaboration human algorhitm interaction ethical ai human in the loop responsible ai fair ai human oversight
Determining Impact of Viruses on Biogeochemical processes In Soil (DIVOBIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

Microorganisms have a central role in soil biogeochemical processes. Essential functions include nutrient cycling, controlling greenhouse gas fluxes and supporting crop productivity. Soil is one of the most diverse habitats in the biosphere. High throughput sequencing has enabled characterisation of microbial communities, and determination of drivers such as climate and land use are well underway. However, we are only beginning to recognise the scale of viral diversity in soil, and importantly, the impacts of virus-host interactions on key soil biogeochemical cycles and subsequent functional consequences on ecosystems are unknown. Viruses have a range of life strategies, including infection and lysis of host cells or integration followed by lysis, facilitating horizontal transfer of genes and augmentation of function. When a host is lysed, cell contents are released into the labile organic matter pool. In marine systems, 40% of prokaryotes are lysed per day, releasing 150 Gt carbon per annum. However, there is a paucity of information about the impact of top-down control by viruses on soil populations nor the scale of the viral shunt of nutrients. It is likely that viruses have a major impact on microbial diversity and nutrient cycling, with consequences for ecosystem processes. Here we propose a research programme that not only aims to characterise active viral communities in situ, but advances the state-of-the-art by identifying actual impacts of viruses on selected key biogeochemical processes. Specifically, using a series of soil microcosm incubations utilising 13C stable isotope analysis, high throughput metagenomic and metatranscriptomic approaches, in combination with measurements of soil N and C fluxes, we will characterise, for the first time, active viruses together with direct measurements of their impact on biogeochemical cycles.

Keywords: microbial ecology,viral ecology,soil ecology,nitrogen cycling,carbon cycling
TRUstworthy huMAN-centric artificial intelligence (TRUMAN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: France,Italy,Israel,Sweden,Cyprus,United Kingdom,Germany,Netherlands,Türkiye,India
Call: Explainable and Robust AI (AI Data and Robotics Partnership) (RIA) (HORIZON-CL4-2024-HUMAN-03, 2024)
Start date: 2025-07-01
End date: 2028-06-30
Duration (months): 36.0
Total project cost (EUR): 6538315.0
EU funding (EUR): 6510565.0
Participants: 12
Project status: SIGNED

Artificial Intelligence (AI) has become the main driver of growth in information technology, touching all sectors in the industry, ranging from healthcare, to finance, and transport. The goal of TRUMAN is to design and develop generic technologies and methodologies for improving AI systems’ resilience against security, privacy, and fairness attacks, as well as to increase the trust that their users have in these systems, while accounting for different phases of the AI life cycle, starting from data collection through training and deployment. TRUMAN will encompass three major AI architectures: knowledge graph (KG) representation and learning, continual learning, and large language models (LLMs). These three approaches will be investigated with the goal of designing solutions aimed for scenarios involving dynamic data collection, distributed model training, and scenarios that involve human-in-the-loop (HITL) design principles. TRUMAN will develop customized robustness solutions for both existing and newly developed privacy, adversarial, and fairness attacks. The project will also consider the impact of these solutions on humans, how to explain to them the underlying technologies and the risks, and employ their help in the improvement of these models. These technologies will be evaluated against four use cases illustrating scenarios from different sectors, i.e., marketing, IT, finance, and healthcare. Moreover, the TRUMAN project will strive to generate generic/holistic guidelines and recommendations for building trustworthy and robust AI systems.

Keywords: trustworthy ai,robustness,privacy,human centric ai,hci,fairness,ethical ai,continual learning,knowledge graphs,distributed machine learning
Molecular mechanisms behind filovirus entry and egress: the role of viral glycoprotein glycosylation (EBOVmembrinteract)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

Filoviruses are amongst the most dangerous human pathogens. They pose a great health concern, due to a growing number of emerging species, that vary in tropism and pathogenicity. In my work, I aim at establishing a correlation between filoviruses pathogenicity, the characteristics of their interaction with the cell membrane and their entry and egress potential. In this context, I hypothesize that viral carbohydrates are key in modulating these processes. For this study, I have selected a number of filovirus species, distinct in their pathogenicity for humans. I will use a transcription and replication competent virus like particle system (trVLP) as a BSL-2 virus model, and will produce particles presenting the glycoproteins (GP) from the different filovirus species of interest. GP is the sole glycoprotein found on the virus surface and is crucial for filovirus attachment and entry. Using an interdisciplinary approach combining virology, biophysics and glycobiology, I will first carry out infection assays, to characterize the entry and egress potential of the different particles. I will further investigate the role of two key attachment molecules, heparan sulfate and DC-SIGN in modulating those processes. This will be achieved first on the cellular level, and then on the molecular level, using single molecule force spectroscopy to look at the characteristics of individual ligand-receptor bonds. Extensive glycomic analysis, amongst other via mass spectrometry, will further address the hypothesis that the GPs glycan profile plays a key role in determining the behaviour of the different filoviruses. Taken together, I will provide a comprehensive description of the influence of the different GPs in viral entry and egress, on the molecular, functional, and biological levels. Such insights will without doubt be key to the development of efficient and broad-spectrum antivirals.

Keywords: filovirus,membrane interaction,entry,egress,glycoprotein,glycosylation,afm
Multi-layer 360° dYnamic orchestration and interopeRable design environmenT for compute-continUum Systems (MYRTUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Italy,France,Germany,Netherlands,Austria,Spain,Switzerland,United Kingdom
Call: Cognitive Computing Continuum: Intelligence and automation for more efficient data processing (AI, data and robotics partnership) (RIA) (HORIZON-CL4-2023-DATA-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 6632586.68
EU funding (EUR): 5597915.18
Participants: 14
Project status: SIGNED

The “Multi-layer 360° dYnamic orchestration and interopeRable design environmenT for compute-continUum Systems (MYRTUS)” project aims to provide the technology to make CPS evolving towards a living dimension, embracing the technological principles of the TransContinuum Initiative where “edge, fog and cloud computing platforms are being pulled closer together into a seamless execution environment” and “programming has to be reinvented, with languages and tools to orchestrate collaborative distributed and decentralised components, as well as components augmented with interface contracts covering both functional and non-functional properties”. MYRTUS puts together different technologies to design and operate complex, distributed, and heterogeneous CPS computing infrastructures, leveraging diverse cloud to edge technologies, including from off the shelf CPUs to custom AI accelerators, offered by multiple providers. Main MYRTUS results are (i) the MYRTUS reference infrastructure, comprising a diversity of heterogeneous, autonomous, federated and collaborative computing nodes distributed across the computing continuum; (ii) a novel management scheme featuring MIRTO, an AI-powered cognitive engine capable of orchestrating, at 360°, the whole continuum infrastructure, and (iii) the MYRTUS design and programming environment to design, deploy, and operate such complex infrastructures. MYRTUS solutions represent the instruments to unlock the new living dimension of CPS, pursuing also sustainable and responsible computing, openness, security and trustworthiness, and promoting strategic industrial cooperations by establishing synergies with relevant initiatives and projects, as IPCEI, Gaia-X, TransContinuum Initiative. Technology assessment is carried out within two challenging scenarios, Healthcare and Mobility, involving humans.

Keywords: design environment,dynamic orchestration,computing continuum,interoperability and ai