Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Securing the innovation management capacity of Flemish SMEs thourgh KAM and EIMC services within the Enterprise Europe Network (VEBIN SME 3.0)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Belgium
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 153750.0
EU funding (EUR): 153750.0
Participants: 2
Project status: CLOSED

Continuing the services of enhancing the innovation management capacity of SME's by the Enterprise Europe Network in Flanders and ensuring the KAM services for SMEi, FET and FTI on behalf of H2020 (EIC) for Flemish SME participants during 2019. This project aims at continuing the services of EEN in Flanders with regard to the key account management for the SME instrument under H2020 as entrusted by the European Commission to the Enterprise Europe network. It also concerns the additional support services that EEN will deliver with regard to the enhancement of the innovation management capacities of SMEs as decided under the mandate the EEN received from the H2020. The present proposal describes how the Flemish VEBIN consortium will continue to realise these services in the region of Flanders and extended also to SMEs that will be beneficiaries of FTI and FET under H2020, how these will be embedded in the regional innovation support system to the benefit of Flemish SMEs, how the consortium will manage the services and how feedback will be organised in order to ensure a high quality service provision and an added European value. It particularly reflects on the smart signposting of clients among all relevant support stakeholders and to the efficient use of existing tools. It also expresses the consortium willingness to cooperate whenever requested by the Commission or by EASME to participate in benchmarking exercises among the various participating consortia and to give feedback on the implementation of the services in the region of Flanders (Belgium). Particular attention will also be given to guarantee the synergies between the activities in this present proposal and the regular EEN services that the consortium is provinding in the region so as to realise fully the client journey and hub&spoke approach as laid down in the ToR of the COSME caal for the EEN with regard to the WP 2019.

Keywords: innovation management capacity,eimc
What is bedouin-type Arabic? The linguistic and socio-historical realities behind the millennia-old dichotomous concept of nomadic and sedentary people in the Middle East and North Africa (WIBARAB)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Austria
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2455891.0
EU funding (EUR): 2200751.0
Participants: 2
Project status: SIGNED

This project will investigate the linguistic differences between originally nomadic and sedentary people, i.e. one of the key concepts in the history of the Arabic language and the grouping of its contemporary spoken varieties. While the dichotomy between Bedouins and sedentary communities is of crucial importance for the (social) history, economy, and linguistic identity of the Arabic speaking Middle East and North Africa, it is still insufficiently understood. WIBARAB aims to establish for the first time a robust set of linguistic phenomena that characterize the bedouin-sedentary split. To this end, it not only considers (1) phonological and morphological features as hitherto has been done, but also (2) typology, grammaticalization pathways, syntax, phraseology, and lexicon, and (3) the influence of intra-dialect contacts and historical migrations. WIBARAB will provide new data from three under-researched Arabic varieties and investigate linguistic attitudes towards bedouin-type dialects on the basis of five case-studies with different social and geographical settings. Its holistic approach challenges well-established views and methodically shows how diachronic linguistic data can provide proxy data for history and vice versa. WIBARAB also studies the impact of social settings, particularly tribal and patriarchal structures, as possible factors for the linguistic conservatism of contemporary bedouin-type Arabic. It includes recent findings in human genome analysis where appropriate and ethically acceptable, and makes ample use of the possibilities provided by digital humanities. WIBARAB adopts methods grounded in general linguistics, sociolinguistics, and historical interpretation to shed light on a phenomenon of fundamental importance in the history and the present of one of the world’s largest languages.

Keywords: arabic,spoken language,historical linguistics,language and dialect contact,dialectology,areal linguistics,language typology,nomadic communities
Enabling sustainable AiR MObility in URrban contexts via emergency and medical services (AiRMOUR)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Finland,Sweden,Norway,Sweden,Norway,Finland,Netherlands,Netherlands,Luxembourg
Call: Towards sustainable urban air mobility (H2020-MG-2020-SingleStage-INEA, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 5646150.0
EU funding (EUR): 5646150.0
Participants: 14
Project status: SIGNED

AiRMOUR focuses on research and validating novel concepts and solutions to make urban air mobility safe, secure, quiet and green but also more accessible, faster, affordable and publicly accepted. In response to the call, AiRMOUR presents an approach that takes on one of the most critical and challenging early real life applications of UAM in Emergency Medical Services (EMS). EMS provides a versatile scenario pool that facilitates thoroughly investigating the urgent challenges at hand applying a result driven quadruple helix approach. AiRMOUR fills in the excellence gaps and drastically advances the understanding of needed near-future actions by urban communities, operators, regulators, academia and businesses. The approach and the outcomes will massively benefit the entire UAM development in EMS, but also widely within e.g. the vision of true airborne mobility genuinely supplementing traditional transport modes. AiRMOUR concept centers on thorough research of safety, regulation, user acceptance, sustainability; leveraging them into practical and real-life tangible UAM tools after TRL6 live validations. A strong consortium of research, national aviation, regional and local urban authorities, UAM operators and EMS can guide cities making sure that the impacts are replicated widely. Main outputs are UAM toolbox with a UAM GIS tool for authorities, a UAM guidebook (for cities, operators and other stakeholders) and a UAM training programme together with Eurocontrol, all tested by cities and replicators. The crucial impact of AiRMOUR will be increased UAM competence of city and regional staff and their partners in public transport, energy, innovation and funding. Participation in AiRMOUR allows hands-on testing of the UAM toolbox as well as take-up of future UAM scenarios. Each European local cluster of aviation and urban actors will be able to set-up their own UAM realisation. European policy making and investments will be reinforced with AiRMOUR findings and knowledge.

Keywords: functional smart cities,sump,competence building,emergency and medical services,business models,safety,security,urban air mobility,public acceptance
Quantum Nanomaterials by Twistronics (QTWIST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 2880313.0
EU funding (EUR): 2880313.0
Participants: 1
Project status: SIGNED

Van der Waals heterostructures, assembled from 2D materials, offer unprecedented opportunities for the material design by layer-by-atomic-layer construction of artificial solids. The potential of this approach is enormous, as demonstrated by the hundreds of patents and thousands of research publications appearing annually in the field. This proposal will explore a new avenue in design of quantum solid state systems by employing a mutual rotation between adjacent crystalline planes, “twist”, to pattern their properties on the nanometre length scale. This opportunity has emerged due to my recent pioneering work with twisted layers of transition metal chalcogenides and ground-breaking technological achievements in ultra-high vacuum fabrication instrumentation. I will transform the emerging field of “twistronics” by the in-situ fine-tuning of moiré superstructure and making pioneering studies of novel quantum and strong correlation phenomena in 2D materials accessible for the first time. In particular, I will explore different regimes of lattice reconstruction in 2D semiconductors to engineer and study (1) quantum many-body states of electrons and (2) design confined quantum states defined by piezoelectric and pseudomagnetic nanotextures in semiconducting and charge density wave 2D materials. Moreover, we will create and study world-first twisted heterostructures with (3) superconducting and (4) superconducting and magnetic 2D materials, aiming to create strong periodic nanotextures of their electronic states. The realisation of my ambitious research programme is only possible due to our unique world-first UHV-technology which will allow assembly of high-quality twisted van der Waals heterostructures, and which we will develop to enable new dynamic twist-angle studies and local magnetic flux measurements. The potential impact of this proposal is ground-breaking for both fundamental science and nanotechnology, opening up a new route for nanoengineering of solids.

Keywords: 2d materials,superlattice,quantum materials
Country of Words: Reading and Reception of Palestinian Literature from 1948 to the Present (PalREAD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-04-01
End date: 2023-07-31
Duration (months): 64.0
Total project cost (EUR): 1493439.0
EU funding (EUR): 1493439.0
Participants: 1
Project status: SIGNED

This project proposes a deep and thorough study of Palestinian literature as an early and on-going case of literary displacement. It aims to find new ways to account for and analyse texts, literary production and reading publics that challenge and lie outside conventional conceptions of the nation-state. The proposed methodology will take a novel approach in merging textual analysis with reception theory and reading practices. The project is ambitious in seeking to be the first instance to explore its application on the scale of an entire ‘literature-of-a-nation’. By doing so, the project aims to introduce methodological innovations that can expand horizons beyond textual and national analyses towards interdisciplinary models that contend with the multi-faceted and unconventional dimensions of the Palestinian case, and generate a richer and more nuanced history of its literature. The proposed project will explore, for the first time under one analytic roof, all the geographic fragments of Palestinian literature together, traditionally studied separately, or limited to certain authors or time periods. The project’s novelty also lies in broadening the horizons of literary analysis towards an interdisciplinary and transmedial approach that embeds literary production into a wider cultural web of intersecting media and genres. A creative approach will be developed to overcome the hurdles of working, in the Palestinian case, with few scholarly precedents, and scattered, lost or damaged primary and secondary sources. The project’s four work packages will trace connections and disconnections and transformations of publics and reading practices across dispersed Palestinian literary communities of writers and readers over time. The focus will be on identifying, tracing and elaborating key and/or turning point moments across the various localities of the Palestinian literary sphere. An online platform will visual, digitalize and make accessible the project’s outputs.

Keywords: modern arabic literature,palestinian literature,palestinian culture,world literature
A portable peritoneal dialysis system for home use that monitors for infection (LPPDS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

End Stage Kidney Disease (ESKD) or End Stage Renal Disease (ESRD), the fifth and last stage of Chronic Kidney Disease (CKD), is recognised as a major public health problem. It occurs where kidneys are no longer capable of sufficiently filtering waste products from the blood. With kidney function at less than 10 %, a kidney transplant or an external means of filtering is needed. The latter consists of either Haemodialysis (HD) or Peritoneal Dialysis (PD). Globally, we are seeing an increasing prevalence in ESRD. This is caused by an aging population in the west, socio-economic factors, increasing hypertension, and growing diabetes and obesity epidemics. The technical complexity of market offerings can inhibit many patients from choosing PD. HD takes an average of 4 hours per treatment session and occurs 3 times a week while PD occurs 4 times a day with each exchange requiring 40 minutes on average. Most dialysis occurs in specific dialysis centres and hospitals, adding further time for travel. Non-compliance with treatment schedules are a particular issue with PD. This makes it difficult for doctors to calculate correct treatment plans as patients may not share this information with their doctor. Non-compliance can be as high as 53%, decreasing efficacy of the treatment leading to poorer health overall and speeds up rate of decline. liberDi revolutionises traditional Peritoneal Dialysis with LPPDS, a smart, real-time, patient-monitoring, truly portable device. It’s lightweight, easy to set up and allows patients carry out their dialysis at home, at work or while travelling. LPPDS has UX at the very core of its design to ensure ease of use: patent pending smart automation, catheters and sterile connectors. The system consists of a patent-pending disposable that holds a smart peristaltic pump designed to improve adherence to protocol, and reduce human errors, while saving time via fluid flow rate and management.

Keywords: peritoneal dialysis,infection reduction,infection detection,homecare,point of care,patient independence,improved treatment,patient quality of life,patient mobility,improved healthcare outcomes
Mapping Cancer Response using Organoids and Mass cytometry (MaCaROM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: CLOSED

Breast cancer is the most common form of cancer in women and has a very variable prognosis. Efficacy of anticancer therapies is limited by intertumor and intratumor heterogeneity. To take these into account, tumor models should recapitulate native tumor heterogeneity and should be analysed at the single-cell level. Here, we propose to take advantage of the conserved heterogeneity of breast cancer patient-derived organoids in order to analyze their response to 45 FDA-approved drugs. These responses will be mapped in a single-cell atlas of sensitivities using mass cytometry, and the use of this atlas will be assessed for the prediction of drug sensitivity in future patient tumors and to guide treatment. We plan on exploring the best hits of this screening using imaging mass cytometry to have a spatial view of the evolution of the tumor ecosystem over time after drug treatment. This should positively impact patient treatment and survival and, more broadly, could lead to the new concept of “mapping-based precision medicine”. This project will also uncover the biology of resistance to drug treatments at unprecedented resolution. The study of the different cellular populations composing breast tumors, and their interactions, will lead to a better understanding of the tumor ecosystem and to the identification of therapies targeting specific cellular populations that could trigger tumor demise.

Keywords: patient derived organoids,mass cytometry
History and Theology (HISTHEOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

'History and Theology: the creation of disinterested scholarship from dogmatic stalemate (ca. 1525-1675)' will deal with the question of how and why the seeds of religious tolerance came to be sown in an age of confessional polemic. This project will explore the idea that an unexpected consequence of religious polemic was the growth of disinterested scholarship, which, in turn, led to increased tolerance of religious differences. Indeed, once the strict rules and staunchly held positions of the rival confessional antagonists became known and established, scholars were able to pursue their research relatively freely within this framework and even across confessional boundaries. It became possible to describe change and diversity as historical facts rather than as simply polemical weapons in a battle of the books. In turn, this paved the way for the religious tolerance championed by several influential Church histories of the Enlightenment. The project will focus on two cultural zones: England and the Italian peninsula, in order to conduct a comparative study of a carefully selected number of key scholars from rival confessions and scholarly traditions. By means of a carefully calibrated dissemination strategy, this project is intended to have a wider impact on Europe’s troubled multi-faith society of the early twenty-first century by providing a fresh, new historical narrative which adds intellectual foundations to the moral desirability for mutual recognition and appreciation of diversity in religious debate.

Keywords: theology,religious history,early modern history,history of tolerance
In silico design and assessment of novel polyelectrophylic chemotherapy agents (SN2DNA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2024-05-31
Duration (months): 36.0
Total project cost (EUR): 259398.72
EU funding (EUR): 259398.72
Participants: 1
Project status: SIGNED

Administration of DNA-damaging reagents constitutes one of the most effective chemotherapeutic strategies for the cancer treatment. The families of drugs developed over the years for this purpose are based on second-order nucleophilic substitution (SN2) reactions. Innovative candidates to improve the therapeutic action of these compounds have been designed based on increasing the number of electrophilic positions (En) of the reagent by making n>2. This increased electrophilicity must generate interstrand crosslink adducts that should result in irreversible lesions in the DNA of cancer cells. Computational chemistry tools based on quantum mechanics and molecular modelling, constitute key tools for a better understanding of DNA damage and repair after the formation of the covalently bound complexes that distort the double helix. Thus, the aim of the project described in this proposal is to: 1) compute the structures and evaluate the distorting effects of DNA adducts with polyelectrophilic chemotherapeutic reagents, 2) compute the kinetics of the consecutive SN2 processes (on both carbon atoms and metallic centres) involving interstrand and intrastrand crosslinks and 3) assess in silico the ADME (Adsorption, Distribution, Metabolism and Excretion) properties of the synthesised candidates. Those objectives will be achieved by computing the behaviour of different families of molecules through quantum mechanical - at DFT level of theory- and Molecular Mechanics calculations - based on QM/MM method. Some of these candidates have been synthesised in the laboratories of the hosting group and the corresponding preliminary and promising biological results are already available. The outputs of this project will result in a patent proposal and research articles to be published in high impact journals. Our findings will be open-access available in order to contribute with the research on anticancer drugs design.

Keywords: sn2 reaction,cisplatin,in silico drug design