Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dencatistat, a first-in-class, tumour-agnostic, orally available CTPS1 inhibitor to treat solid tumours (STP938Dencatistat)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 18.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Step Pharma’s proposal aims to revolutionize cancer treatment with the development of dencatistat (STP938), a first-in-class, tumor-agnostic, orally available CTPS1 inhibitor. Founded in 2014 as a collaboration between Kurma Partners, the Imagine Institute, and Sygnature Discovery, Step Pharma specializes in precision oncology, targeting metabolic vulnerabilities in cancer cells. Dencatistat selectively inhibits CTPS1, a critical enzyme for DNA synthesis in cancer cells, offering a safer, highly targeted alternative to traditional therapies, with minimal toxicity. Step Pharma’s drug development efforts first focused on lymphocyte-driven disorders because these diseases rely heavily on CTPS1 for cell proliferation, creating a specific vulnerability that allows for selective targeting with minimal toxicity - dencatistat STP938 – has shown clinical activity in T and B cell lymphomas. Through the EICA project, Step Pharma aims to advance the clinical development of dencatistat, focusing initially on CTPS2-null ovarian cancer, which affects 300,000 patients annually and has a 5-year survival rate of less than 30%. By validating this synthetic lethal strategy in Phase 1b clinical trials, the project could pave the way for broad applications in other CTPS2-null cancers, such as bladder, lung, and gastroesophageal cancers, establishing dencatistat as a universal cancer therapy (expanding into solid tumours is critical because global prevalence/unmet need) Step Pharma has raised €52 million to date, including €35 million in Series B funding and €1 million in innovation loans. The company is seeking €2.5 million in grants and €10 million in equity through the EICA program to support GMP manufacturing, Phase 1b clinical trials, and regulatory preparation for Phase 2. This investment will enable Step Pharma to disrupt the €200B global oncology market, delivering life-changing therapies to cancer patients worldwide and contributing to Europe’s leadership in precision medicine.

Keywords: solid tumours,ctps1 inhibitor,cancer treatment,oral medicine,ovarian cancer,tumour agnostic,cancer targeted therapy
Polar Snow, Permafrost, and Inland Ice in a changing world (SnowPI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Norway,Germany,United Kingdom,Denmark,Belgium,Austria,Sweden,Finland,France,Ukraine
Call: Inland ice, including snow cover, glaciers, ice sheets and permafrost, and their interaction with climate change (HORIZON-CL5-2024-D1-01, 2024)
Start date: 2026-03-01
End date: 2030-08-31
Duration (months): 54.0
Total project cost (EUR): 7499533.0
EU funding (EUR): 7499533.0
Participants: 14
Project status: SIGNED

The effects of present-day climate change are clearly visible in the frozen parts of our planet, where ongoing glacier melt, accelerating ice sheet retreat, permafrost thaw and declining snow extent are well documented. This is especially evident in the polar regions which are warming faster than the rest of the world which will have global and regional impacts. Here, climate adaptation remains challenging, partly due to uncertainties in climate projections arising from insufficient understanding and model representation of snow, glaciers, ice sheets, and permafrost, and their interactions with the atmosphere and ocean. Snow plays a central role in modulating the cryosphere’s response to climate change. Yet, snowpack and snow processes remain poorly understood, observed, and modelled. SnowPI will advance our understanding of, and ability to observe, study, and project changes in the frozen terrestrial surface through the lens of snow. SnowPI will achieve this by exploiting emerging technologies, latest scientific discoveries, state-of-the-art models, in-situ and remotely sensed observations alongside its novel observations and model advances. Uniquely, SnowPI will also pursue a novel approach to developing climate information in support of adaptation strategies in the polar regions. This approach follows two converging pathways to deliver climate information in support of climate adaptation that can exploit emerging scientific and model advances more swiftly than traditional approaches. The contributions from SnowPI will include 1) new knowledge and improved capabilities to model and observe changes in snow, glaciers, ice sheets, and permafrost; and 2) state-of-the-art assessments of regional and global impacts of the changing cryosphere to support climate adaptation strategies. Combined, these results benefit a wide range of actors both within and beyond the polar regions by improving their capability to respond to the impacts of climate change.

Keywords: arctic climate change,antarctic climate change,polar cryosphere,climate change impacts
BUILDING CAPACITIES IN INNOVATION PROCUREMENT FOR CITIES (BUILD)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Slovakia,Estonia,Finland,Netherlands
Call: Building capabilities in innovation procurement (HORIZON-EIE-2021-CONNECT-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 606300.0
EU funding (EUR): 498187.5
Participants: 6
Project status: CLOSED

The Building Capacities in Innovation Procurement for Cities (BUILD) project will roll out a number of training and capacity building actions targeted at upskilling the public procurers on the topic of innovation procurement. Public procurement is a powerful instrument to drive faster adoption of innovation among public sector users while simultaneously promoting economic growth by providing innovative companies opportunity for first user references. The strategic use of procurement to boost demand for innovative goods of services has become an important part of the innovation policy agenda in many EU countries, and is at the core of the new EU public procurement directive (2014/24/EU), which underlines importance of opening opportunities for public procurement of innovation (e.g. by introducing a new innovation partnership procedure). BUILD integrates the highest-quality capacity-building tools to facilitate the roll-out of capacity building and training services to cities. BUILD will engage and train public – private procurers, SMEs and startups via both onsite and online avenues on a number of topics like; 1) Guiding Principles (Valonia) 2) Legal Knowledge and Procedures (Rotterdam) 3) Preliminary market consultation (CE) 4) Pre-commercial procurement (Turku) 5) Competitive dialogue (Turku) 6) Competitive procedure with negotiation (Tartu) 7) Innovation partnership (Valonia) 8) Legal questions and considerations (Rotterdam) and 9) Risk assessment (Valonia). Lastly, BUILD will link and establish synergies with research and innovation projects funded by the EU (via Horizon Europe or other EU funding programmes), with specific focus on EU funded projects fostering PPI, with the aim of facilitating mutual learning and knowledge exchange and will also set up a pro-active dissemination action which will facilitate outreach to key target audiences, namely; public and private buyers, public-owned enterprises, SMEs and start-ups, research institutions among others.

Keywords: public procurement of innovation,capacity building,green cities,training,knowledge transfer,european cities,mutual learning,public procurement,pre commercial procurement
SUSTAINABLE DEEP TECH INNOVATION FOR AQUATIC OIL SPILLS CLEAN-UP (InnoAerogel)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Lithuania
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-06-01
End date: 2024-05-31
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Inobiostar is an early-stage start-up leaded by CEO and Founder Dr. Tatjana Paulauskiene. The company was founded in 2020 as a spin-off company of Klaipeda University with the aim to create and develop deep tech innovations towards clean seas. Inobiostar was excited to participated in "TechHub" startups pre-accelerator tprogram in 2021 where the idea of InnoAerogel became TOP5 at TechHub Demo Day. We were selected to be a part of “Baltics & Slovakia ClimAccelerator 2021: Accelerator for climate-positive startups” supported by Climate-KIC. Inobiostar together with the strategic partner – Klaipeda University in 2021-2022 implemented the product commercialisation project InoBioTech Baltija (Development of a biotechnological treatment method for oil spills in the Baltic Sea). Inobiostar is currently in the process of receiving de minimis grant from Klaipeda Science and Technology Park (InoSpurtas) and Lithuanian Innovation Centre (InterInoLT) for consultancy services. Our new brand product is InnoAerogel – sustainable, highly efficient, biodegradable and reusable waste paper based material – sorbent for aquatic oil spills clean-up. The idea is patented in State Patent Bureau of the Republic of Lithuania and is being patented in European Patent Office. The problem which we are solving have never been so actual for the human with arising awareness on climate change and health. We see our mission to contribute significantly to the efforts of modern society to save the future. The objective of this project is to develop InnoAerogel innovation from early stage and non-investment ready to modern, knowledge-driven, resource-efficient and competitive product on the global market leaded by woman. During the project implementation we are planning to perform 3 main tasks: to prepare for fundraising and EIC Accelerator, to find key innovation partners and encourage more women to join blue biotech sector.

Keywords: innovation management
Recapitulating the growth of the human heart to mature cardioids (CardioGROWTH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Austria
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 3571428.57
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Cardiovascular disease (CVD) is the leading global cause of death. Yet, breakthroughs in cardiac therapies are limited due to the poor predictive power of current models. While the animals fail to accurately replicate human heart physiology, the human pluripotent stem cell-derived models remain underdeveloped and immature for reliable disease modeling and therapy development. To address these challenges, we propose to further develop our cardiac organoid (“cardioid”) model and recapitulate the key stages of heart growth, including trabeculation, compaction, vascularization, and postnatal hypertrophy, resulting in physiological-like maturation. We hypothesize that these processes lead synergistically to postnatal heart maturation. Guided by developmental principles, we will combine signaling, metabolic, and genetic manipulations, as well as quantitative morphometric, functional, and molecular readouts on our high throughput cardioid platform. By leveraging advanced technologies (e.g., light sheet microscopy and single-cell proteomics), we will develop a physiologically relevant cardiac model that enables predictive cardiac disease modeling and drug discovery, paving the way for innovative therapies and regenerative medicine.
Accounting for human behaviour in risk assessments of zoonotic spillover and international spread of infectious diseases in scenarios of global change (KASSANDRA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2029-01-31
Duration (months): 36.0
Total project cost (EUR): 413379.72
EU funding (EUR): 413379.72
Participants: 2
Project status: SIGNED

Zoonotic spillover and the subsequent global spread of infectious diseases represent an increasing global threat to our society. Projections of future zoonotic spillover events are based on the spatial copresence of human and animal host population and risk assessments of local outbreaks to spread globally rely on observed mobility data. However, human behaviour is a complex phenomenon driven by socio-economic, environmental and demographic factors that altogether shape human mobility patterns and the human-host contact rate, which is key to zoonotic spillover. By impacting these drivers, future global economic, demographic, environmental and climate change will alter the risk of zoonotic spillover and global spread of infectious diseases. Here, focusing on scenarios of future climate and land-use change, demographic and economic development (SSP-RCP), I intend to (i) produce maps of future spillover risk that account for the behavioural determinants shaping human-host contact and (ii) assess the risk of the global spread of future infectious diseases. I will focus on infectious diseases of bat origin and I will estimate the effect of economic, demographic, environmental and ecological drivers in defining human-bat contact rates. Drawing on these results I will produce synthetic human-bat contact data and maps of future risk of zoonotic spillover. Then, I will use the risk maps to assess the risk of the global spread of future infectious diseases. To this end, I will use a global metapopulation model informed by projections of international human mobility patterns that will be obtained from a global international human mobility model that I will develop. In doing so I will include key drivers and behavioural processes (e.g., economic constraints) of human mobility. The outcome of the project will advance our understanding and preparedness to future zoonotic spillover and pandemic risks by accounting for human behaviour drivers in a context of global changes.

Keywords: zoonotic spillover,infectious diseases importation,human behaviour,scenarios,human mobility,socio economic development,land use change,climate change
The Identification of the Reactive Pore Space in Soils (EXPOSOIL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Belgium
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2498535.0
EU funding (EUR): 2498535.0
Participants: 1
Project status: SIGNED

Ensuring the quality of our soils is essential for a sustainable world. Testing the soil quality traditionally occurs by soil sampling, sieving and extraction, thereby disturbing the soil’s hierarchical pore size structure. Soil sieving and extraction disrupts the macro-aggregates and overestimates the accessible reactive surfaces of soil. Plant roots are exposed to only a fraction of these soil reactive surfaces, hence traditional soil tests for bioavailability underscore the physical non-equilibrium of nutrients and contaminants in soil. EXPOSOIL aims to identify the reactive pore space to which roots are exposed in undisturbed soil. The research objectives are to quantify the effects of soil structure and mobile colloids on bioavailability of nutrients and contaminants and to develop methods to understand and diagnose these effects. We speculate that these effects create local heterogeneities that are most important in soils with stronger aggregate structure, for contaminants or nutrients that are relatively immobile and less aged in soil and for elements strongly associated to mobile colloids. Experimental studies will be set up to test these hypotheses in soils with surface amended trace metal contaminants, fertilisers or lime, using isotopes to trace local provenances and using novel visualisation tools. Novel reactive membranes acting as zero sinks for solutes and colloids will be developed to mimic plant roots and to make 2D images of the locally available elements. That development is of high risk but high gain because no other method has yet assayed diffusive fluxes of solutes, let alone of colloids, in unsaturated and undisturbed soils. The new method will disclose the enigmatic roles of soil physical factors and colloids on bioavailability. This knowledge will advance the practical use of soil chemistry in environmental applications, e.g. to improve existing soil testing assays and to facilitate the development of novel, more efficient fertilisers.

Keywords: bioavailability,colloids,trace metals,fluxes,environmental radioactivity
CARLA: CELLULAR ACTIVITY RNA-BASED ELISA FOR SIMULTANEOUS IDENTIFICATION AND EVOLUTION OF MICROBIAL THREAT STATUS TO HELP WATER RESOURCE MANAGERS ACT BEFORE BEING TOO LATE (CARLA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 30.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 1
Project status: SIGNED

Climate change and human pollutions have significantly accelerated the eutrophication of aquatic environments, modifying the frequency, intensity and seasonality of harmful algal blooms worldwide. Their capacity to release deadly toxins makes them a serious health, environmental and economic threat, illustrated by annual global direct economic losses of >>5 bn€. Because blooms can appear and disappear in 2 to 3 days, it can go unnoticed by current monitoring solutions, which provide late or uncomplete results. This is a real challenge for water managers to daily monitor microbial quality. They’re looking for solutions able to quickly identify the nature of microbial threats and predict their evolution to be proactive and take action before it’s too late. Early identification and warning are the key to risk prevention and sustainable blue growth. Microbia Environnement (ME) has developed CARLA, a game-changing solution able to simultaneously identify microbial threats and their level of activity in less than 3 h. Water managers can identify blooms types and timeframe to adjust the amount and duration of water treatment/ site closure to decrease costs and protect end users faster and better than any other existing value proposition on the market. For water testing laboratories, CARLA offers a competitive edge with its high throughput capacity and low-cost format. Today, ME address the market of the microbial quality of water estimated at ~€5 bn by 2028. Over 100 million water samples are tested every year in Europe. This number is set to grow as new advanced, rapid, efficient and cost-effective technologies are introduced. We work with water utilities, local authorities and water testing laboratories, all are valuable partners in technology dissemination. The company will have 3 revenues types: CARLA services (25k€/services), CARLA kits (350-450€/unit) and patent licensing. ME is looking for funds to accelerate its development and industrialization of its operations.

Keywords: water microbial quality,harmful algal blooms,risk anticipation,genetic biosensors,water sustainable management,water cost efficiency,reactivity and actionability,big data,sdgs 6,13,14,15
Functional Calculus for Computational Statistics (FunCalc4Stats)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-04-01
End date: 2031-03-31
Duration (months): 60.0
Total project cost (EUR): 1497370.0
EU funding (EUR): 1497370.0
Participants: 1
Project status: SIGNED

Computations with spatial or spatiotemporal data occur in various areas such as the social and environmental sciences. The technological progress in data collection and storage capacities in recent years has caused a tremendous growth in data, and thereby exposed the limitations of state-of-the-art computational methods for statistical inference and predictions. Achieving computational feasibility severely limits the dependency structures of underlying random processes in currently deployed models. Above all, there is a strong need for methodologies that capture intricate spatial or spatiotemporal dependencies. This project seeks to characterize flexible dependency structures by means of functional calculus and to exploit this characterization for efficient computations with Gaussian processes. My overall aim consists of a systematic construction and approximation of covariance operators, corresponding to sophisticated nonlocal dependencies, via the action of functions on local linear differential operators. To establish numerical methods for operator functions, I will consider contour integral representations. Expedient transformations of the contours will facilitate operator-valued quadratures based on sinc approximations, which I will combine with uniformly stable discretizations for variational formulations of partial differential equations (PDEs) such as elliptic diffusion, parabolic and Stokes equations. To derive sharp rates of convergence, I will employ discrete inf-sup theory. Thereby I will address specific classes of functions and of differential operators suitable for inference from data. A particular focus will be on spatiotemporal statistical models based on fractional powers of non-autonomous parabolic operators, for which I will analyse space-time finite element methods. This project will considerably strengthen the interaction between Numerical Analysis and Statistics by enabling PDE-based methodologies for efficient computations with spatial data.

Keywords: finite element method,inf sup theory,space time variational formulations,stability and convergence of numerical methods,gaussian measures on hilbert spaces,spatial statistics,kriging