Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Microrheology of two-dimensional active colloidal crystals and glasses (MicACol)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-04
End date: 2019-09-03
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Self-propelling colloidal particles, originally designed to mimic living microorganims, offer exciting opportunities to engineer smart materials equipped with activity. To date, the behavior of synthetic microswimmers has been extensively studied in homogeneous environments, close to confinements and in semi-dilute suspensions. However, for materials’ design, the use of solid-like phases, such as crystals and glasses, is highly desirable. While recent numerical simulations have invested a lot of effort in understanding the structural and mechanical properties of dense colloidal materials with activity, experiments significantly lag behind. One difficulty stems, for instance, from the presence of short-range attractive forces that affect the active motion when two of more microswimmers come near contact. In this project, we will investigate the mechanical properties of dense monolayers made partly or entirely of self-propelling colloids using microrheology. We will assemble colloidal monolayers at a flat oil/water interface, where long-ranged repulsive forces will lead to the formation of crystals and glasses with loosely-packed configurations, i.e. with particles that are far from contact. We will mix passive Brownian particles with a controlled amount of active platinum coated particles that self-propel due to a catalytic reaction with hydrogen peroxide dispersed in water. We will elucidate the intimate relation between structure, activity and mechanical properties of dense active suspensions using microrheology experiments, in which we will analyse the fluctuations of a probe driven through the active material by means of an optical tweezing. Our results will shed new light on the unexplored physics of active crystals and glasses and provide a protocol to quantify their mechanical properties. While the proposal research is primarily fundamental in nature, our findings will serve as benchmarks for the design of novel active materials and devices.

Keywords: colloids,active,microrheology,self propelled particles,microswimmers,colloidal crystals,colloidal glasses,optical tweezer
A natural and high quality ingredient for dietary supplement derived from yeast fermentation to reduce oxidative stress and promote health and wellbeing (AstaFerm)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2019-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Oxidative stress is an imbalance between the production of reactive oxygen species and the ability of the human body to counteract their harmful effects through neutralization by antioxidants. Oxidative stress is the major cause of the cellular damage at the basis of age-related diseases, such as atherosclerosis, cancer, diabetes, rheumatoid arthritis, cardiovascular diseases, chronic inflammations, stroke and other degenerative diseases. The best way to reduce oxidative stress is the intake of antioxidants. Astaxanthin (AST) is the most effective natural antioxidant used to quench oxidative stress. However, the efficacy of AST currently available on the market is very low, due to its poor concentration, and only suitable for a limited number of applications due to its unpleasant flavour and odour. NextFerm offers AstaFerm™, the most effective anti-oxidant dietary supplement made of natural Astaxanthin. AstaFerm™ is an ingredient for dietary supplement composed of an Astaxanthin-rich extract derived from the fermented biomass of yeast strain. AstaFerm™ proprietary process represents the most efficient, innovatory, and sustainable way to produce a natural, high quality and bio-available form of Astaxanthin, with a neutral flavour and odour. The results are highly concentrated AST crystals that can be refined in multiple applications which today are not available on the market. During the phase 1 project, a go-to-market strategy and a supply chain will be established, as well as further development plan will be drafted. Within the overall innovation project NextFerm will optimise the extraction process of AstaFerm™ before scaling up and perform clinical studies.

Keywords: astaxanthin,anti oxidant,oxidative stress,yeast,fermentation,healthy ageing,wellbeing
PatientDataChain - Blockchain approach to disrupt patient-provider medical records data exchange (PatientDataChain)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Romania
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2020-01-01
End date: 2020-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Setrio’s PatientDataChain blockchain-based technology is a game-changer for decentralizing infrastructure and building a trust layer in the healthcare value chain. This could dramatically reduce time delays, added costs, and human error that plague healthcare value chain today. PatientDataChain has significant power to disrupt healthcare and put data in the hands of patients. PatientDataChain uses Smart Contracts to map patient-provider relationships (here the contract shows a list of references detailing the relationships between nodes on the blockchain). It also puts patient-provider relationships in the hands of the patient, giving them the ability to accept, reject, or modify relationships with healthcare providers such as hospitals, insurers, and clinics. PatientDataChain gives patients and doctors an immutable log of healthcare records. It takes a different approach to incentivation for patients by giving access to anonymized healthcare data in exchange for sustaining the network. It breaks down the existing barriers that currently obstacle communication on patients’ journey along the health value chain. Thus, for the care pathway, the workflows and patient processes are streamlined. The solution improves care adherence, operational efficiency and patient experience thus leading to better health outcomes and lower costs. PatientDataChain will lead to (i) an enhanced exchange of information among health players and stimulation of new synergies, (ii) a reduction of costs and simplification of procedures for demonstrating regulatory compliance, (iii) an increased awareness on patients’ data also among patients themselves together with a better understanding of their health journey, and (iv) generation of big data on the patients’ journey along the health value chain across sector, applications and regions as an unprecedented knowhow for the society, necessary to address emerging health risks.

Keywords: blockchain,smart contracts,patient provider relation,medical records,health records,data exchange,data,confidentiality,privacy,interoperability
Functional Cell Culture Ware (F-CCW) : Technical and Commercial feasible? (F-CCW)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Netherlands
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The market for testing of pharmaceuticals and the demand for human cells for cell therapies will grow substantially. Conventional cell culture and organ- model systems (C-CCW) are complex and expensive, due to chemical coating compounds requiring multiple production steps, and marginally effective as cells stay alive for short periods and/or grow at low speed. The performance of cell culture systems and organ model systems can be dramatically improved by using materials with designed surface topography. Materiomics has invented an innovative TopoChip high-throughput screening technology. The overall aim is to innovatively set up enabling technology to transfer the designed topographies to C-CCW products in a high-volume, low-cost manufacturing process (leading to phase 2 application). It creates the next generation products: Functionalized Cell Culture Ware ( F-CCW )which is simple, highly effective and efficient. Goals in Phase 1 are to: 1. Demonstrate the technical feasibility of transferring designed topographies on C-CCW 2. Explore commercial feasibility of F-CCW: to develop a business plan. 3. Develop production methods for producing F-CCW 4. Select cell culture system applications that allow for the highest expected economic return on investment. 5. Identify (and contact) network partnerships for creating a production facility for F-CCW’s Potential end users are research driven industries of drug development, toxicology, personalized medicine and cell therapeutics. Potential stakeholders are investors, injection moulding specialists, manufacturers of moulds for inlay, testing and research laboratories for medical and toxicological testing and pharmaceutical industry. The market is a global market (EU, US and upcoming Asian markets). F-CCW is a breakthrough in functionality of cell culture. Since F-CCW is not limited to one application only, F-CCW will offer multiple follow-up investment opportunities and create many opportunities for new venture

Keywords: functionalized cell culture ware,topography,surface,breakthrough,toxicology,drug testing,therapeutic,clinical application,cell behaviour,commercialisation,topo chip high throughput technology
3-O-sulfated heparan sulfate translocation in altered membrane biology: A new strategy for early population screening and halting Alzheimer’s neurodegeneration (ArrestAD)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Poland,France,France,Netherlands,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2022-05-31
Duration (months): 65.0
Total project cost (EUR): 3991096.25
EU funding (EUR): 3991096.25
Participants: 9
Project status: SIGNED

ArrestAD proposes a novel and visionary thinking resulting from the demonstration of the central role of a particular heparan sulfate species at the intracellular level in neurons and in circulating cells in the molecular pathology of Alzheimer’s disease (AD). AD is a societal challenge for which there is neither prevention nor possible cure. Research in the field has long been refining classic concepts based on the aggregation of Aβ and tau through initial seeding and then spreading. Our vision is different and based on the demonstration that tau abnormal phosphorylation and aggregation is triggered by the interaction of tau with heparan sulfates internalized in neurons and circulating cells only in AD [UPEC R.1; P.1,2]. Based in this new concept, ArrestAD will establish links between AD genetics, disease hallmarks, and altered traffic and intracellular accumulation of heparan sulfates to generate new knowledge underpinning the development of new strategies for detection and treatment of AD. This will open to radically new technologies addressing two major objectives: 1) proving that specific and early diagnosis of AD is possible in circulating cells, and 2) demonstrating that a new class of drug candidates are able to preventing and/or arresting AD-neurodegeneration. To reach these objectives, ArrestAD brings together internationally recognized experts in AD clinics and diagnosis, in heparan sulfate biology, transcriptomics, interactomics, carbohydrate chemistry, enzymology, cell biology, animal experimentation with AD models, and a SME specialized in the development of diagnosis kits using circulating cells. The high-risk character of this joint science and technology research is offset by the multidisciplinary nature of the Consortium and the high socio-economic gain resulting from success. Based in this technology, we will build a diverse portfolio of future projects that will result in a long-term benefit for citizens, economy and society.

Keywords: alzheimer disease,tauopathy,heparan sulfate,heparin interactom,monocytes,diagnosis,screening,therapy,cell membrane,sulfotransferase
Multifunctionnal Cabin ReST Area (CRiSTA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Czechia,Netherlands
Call: Multi-functional cabin rest area (H2020-CS2-CFP04-2016-02, 2016)
Start date: 2017-09-01
End date: 2021-07-31
Duration (months): 47.0
Total project cost (EUR): 781891.5
EU funding (EUR): 547324.0
Participants: 3
Project status: CLOSED

Airbus has defined the need for a multi-functional cabin rest area, under JTI-CS2-2016-CFP04-AIR-01-24 Program Area AIR – WP A-5.1.1. Zodiac answers to this call with project CRiSTA (Cabin ReST Area). Zodiac has an excellent track record in cabin concepts, crew rests and galleys (almost 90% market share of galleys in single aisle aircraft), and within the Zodiac group there is knowledge on all required building blocks such as: flexible cabin concepts, light-weight storage, high comfort cabin attendant seats, lighting and a wide variety of systems. The concept envisaged by Zodiac, compliant to the call text, is a flexible, reconfigurable area with minimally (single aisle aircraft) one seat, one bed, a working position and medical equipment, all stowed and folded innovatively in an isolated space. The solution shall be intended for future large aircraft and be scalable to all existing platforms. The space can be used as crew rest, work station, medical area and cultural needs area (meditation, nurturing or prayer). The project will impact resource efficiency (efficient weight/space use, less flight diversions for medical events) and societal needs with increased passenger comfort for passengers with different cultural backgrounds. Zodiac has an excellent track record in obtaining user requirements from interviews with users and use of its cabin experience center in Alkmaar, The Netherlands. Based on requirements, building blocks will be defined and integrated for testing in a representative cabin environment. Additionally also regulatory impact will be defined (medical emergencies, crew resting times). The CRiSTA total grant request to the CS2 JU is € 547.324,- and the total eligible project budget is €781.892,- for the whole consortium consisting of one Zodiac Business Unit which contains two legal entities, in The Netherlands and in the Czech Republic. The project will be conducted over 47 months in close alignment with the overall Airframe ITD needs.

Keywords: multifunctionnal cabin design safety
Roadmaps for A.I. integration in the raiL Sector (RAILS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Research and Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Italy,Sweden,Netherlands,United Kingdom
Call: Artificial Intelligence (A.I.) for the railway sector (H2020-S2RJU-OC-2019, 2019)
Start date: 2019-12-01
End date: 2023-06-30
Duration (months): 43.0
Total project cost (EUR): 299953.75
EU funding (EUR): 299953.75
Participants: 4
Project status: SIGNED

The overall objective of the RAILS research project is to investigate the potential of Artificial Intelligence (A.I.) approaches in the rail sector and contribute to the definition of roadmaps for future research in next generation signalling systems, operational intelligence, and network management. RAILS will address the training of PhD students to support the research capacity in A.I. within the rail sector across Europe by involving research institutions in four different countries with a combined background in both computer science and transportation systems. RAILS will produce knowledge, ground breaking research and experimental proof-of-concepts for the adoption of A.I. in rail automation, predictive maintenance and defect detection, traffic planning and capacity optimization. To that aim, RAILS will combine A.I. paradigms with the Internet of Things, in order to leverage on the big amount of data generated by smart sensors and applications. The research activities will be conducted in continuity with ongoing research in railways, but the methodological and technological concepts developed in RAILS are expected to stimulate further innovation providing new research directions to improve reliability, maintainability, safety, security, and performance. With respect to safety, emerging threats and certification issues will be addressed when adopting A.I. in autonomous and cooperative driving, based on the concepts of "explainable A.I." and "Trustworthy AI". With respect to cyber-physical threat detection, innovative approaches will be developed based on A.I. models like Artificial Neural Networks and Bayesian Networks together with multi-sensor data fusion and artificial vision. Resilience and optimization techniques based on genetic algorithms and self-healing will be addressed to face failures and service disruptions as well as to increase efficiency and line capacity. All those techniques will pave the way to the development of the new "Railway 4.0".

Keywords: artificial intelligence,rail automation,smart maintenance,traffic management,optimization,safety,maintainability,performance
National Contact Points for Climate action, Raw materials, Environment and Resource Efficiency (NCPs CaRE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Coordination and support actions
Countries involved: Estonia,Iceland,Spain,Israel,Italy,Germany,Cyprus,Switzerland,Moldova, Republic of,Belgium,Serbia,Finland,Croatia,Slovakia,Slovenia,Greece,Poland,France,Czechia,Netherlands,Luxembourg,Portugal,Portugal
Call: Facilitating transnational cooperation between NCPs in Societal Challenge 5 (H2020-SC5-2014-one-stage, 2014)
Start date: 2015-02-01
End date: 2021-01-31
Duration (months): 72.0
Total project cost (EUR): 1999933.75
EU funding (EUR): 1999932.0
Participants: 28
Project status: CLOSED

The National Contact Points perform valuable services in guiding and supporting national applicants in preparing proposals for Horizon 2020 funding. We expect that through an enhanced cooperation and networking between these national entities, a higher quality of their consulting services and thus of proposals and projects can be achieved. Therefore, the overall objective of NCPs CaRE is to form a joint cooperation network of experienced and less experienced NCPs on SC5 “Climate action, environment, resource efficiency and raw materials” which aims at pooling their resources and know-how to raise the overall quality of services provided to their clients. By involving 23 formally nominated National Contact Points across Europe, the NCPs CaRE project will significantly strengthen trans-national cooperation. In addition, NCPs CaRE will extensively involve the 26 NCPs that have decided to become “associated partner”. To harness synergies is especially relevant to SC5 NCPs, since potential applicants within this Challenge are very diverse with respect to their scientific or organisational background, level of experience, involvement in transnational networks. Concretely, activities of NCPs CaRE towards this goal include, amongst others, teaming and twinning schemes, the compilation of best practices handbooks and manuals, events, meetings and trainings both on-line and on a face-to-face basis, as well as a wide range of other communication and dissemination tools and platforms. These activities foreseen by NCPs CaRE will contribute to enhancing the impact of R&I in SC5 and ensure a more efficient use of resources and R&I developments by improving the work flow between NCPs, applicants, the Commission, and other parties with a stake in SC5. Tailor-made like they are for the SC5 constituency, these activities will make it easier for all participating and benefitting NCPs to enhance the number of proposals with regards to both quantity and quality.

Keywords: international cooperation,communication,networking,best practices sharing,policy dialogue,sme involvement,trainings,consulting and support services
Tuning Topological Materials by hydrostatic Pressure and uniaxial Stress (TopoPress)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: SIGNED

The discovery of topological phases of matter has driven the attention of great part of the solid-state science community due to its high for future applications, led by the presence of unusual electronic properties, such as extreme large magnetoresistance and anomalous Hall effect. However, topological phases on Ce-based nonsymmorphic materials are rather unexplored. The nonsymmorphic crystalline structure may create band crossings, which are needed for the existence of non-trivial topological phases, while the presence of magnetic Ce ions gives rise to many complex effects, such as magnetism and the Kondo effect. These correlated phenomena result in a promising route to pin the band crossings of nonsymmorphic compounds close to the Fermi level, favoring non-trivial topological effects in transport properties, which may lead to the realization of new spintronic devices. This proposal aims to understand the interplay between strong electronic correlations and non-trivial topological phases in Ce-based compounds. To achieve that hydrostatic pressure and/or uniaxial stress will be used to tune the electronic bands, i.e. moving the band crossings towards the Fermi energy and/or modify the bandstructure, and the magnetic correlations in Ce-based nonsymmorphic compounds, such as CeAlGe and CeSbTe. By performing electrical transport experiments under applied pressure/stress and in magnetic fields, the evolution and interrelation between non-trivial topological phases and strong electronic correlations will be investigated. As part of the experimental work, a new technique will be developed, which combines micro-structured samples with Bridgman or diamond anvil cells. This method will enable the simultaneous realization of magnetoresistance and Hall measurements up to more than 30 GPa. Our findings will significantly enhance the knowledge in strongly correlated electrons systems and topological materials, two fundamental areas of condensed matter physics.

Keywords: experimental physics,strongly correlated materials,topological materials,high pressure,low temperatures