Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Optogenetic Protein Therapy for Multiple Sclerosis (OPTOGENERAPY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Spain,Ireland,Germany,Spain,Spain,Switzerland,Poland,France,Netherlands
Call: Biomaterials for diagnosis and treatment of demyelination disorders of the Central Nervous System (H2020-NMBP-2016-two-stage, 2016)
Start date: 2017-01-01
End date: 2020-01-31
Duration (months): 37.0
Total project cost (EUR): 6233257.5
EU funding (EUR): 4777257.5
Participants: 12
Project status: CLOSED

Optogenerapy proposes a new interferon-ß (IFN-ß) drug delivery system to revolutionize Multiple Sclerosis treatment. The aim is to develop and validate a new bio-electronic cell based implant device to be implanted subcutaneously providing controlled drug release during at least 6 months. The cell confinement within a chamber sealed by a porous membrane allows the device to be easily implanted or removed. At the same time, this membrane acts to prevent immune rejection and offers long-term safety in drug release while overcoming the adverse effects of current cellular therapies. Wireless powered optogenetics – light controlling the cellular response of genetically engineered cells – is used to control the production of IFN-ß. Replacing standard intravenous IFN-ß delivery by subcutaneous delivery prevents short and long term side effects and efficiency-losses related to drug peaks and discontinuation, while saving non-adherence costs. It is a low-cost system enabling large scale manufacturing and reduction of time to market up to 30% compared to other cell therapies, combining: - Polymeric biomaterials with strong optical, biocompatibility and barrier requirements, to build the cell chamber and to encapsulate the optoelectronics. - Optoelectronics miniaturization, autonomy and optical performance. - Optimal cellular engineering design, enhanced by computer modelling, for stability and performance of the synthetic optogenetic gene pathway over long-term implantation. - Micro moulding enabling optoelectronics and membrane embedding for safety and minimal invasiveness. The innovation potential is so huge that a proof-of-concept was listed by Scientist Magazine as one of the 2014’s big advances in science. In our top-class consortium, industrial pull meets technological push, ensuring that the preclinically validated prototype obtained at the end responds to market demands. BOSTON SCIENTIFIC, worldwide leader in neuromodulation active implants, has clear exploitation plans and high market penetration potential. 4 research intensive SMEs: TWO, GENEXPLAIN, NEOS and ULTRASION bring specific competences while increasing their own competitiveness.

Keywords: multiple sclerosis,interferon beta,optogenetics,subcutaneous,drug delivery,cell therapy,therapeutic implant,active implantable medical device
Innovative upright Refrigerator with Improved Efficiency Fully Aligned With The Eu Legislation To Control The F-GASES” (Reficient)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Founded in Angera, (Varese, Italy) in 1990, TEKNA Line, is a leader in the design and manufacture of refrigeration unit specialised in Patisseries, Bars & Restaurants, Ice cream and Supermarkets delivering customised products to suit the needs of our customers. TEKNA Line has always been committed to ongoing research on CO2 consumptions, winning a reputation for products with high efficiency, excellent reliability, easy maintenance and long lifespan. Over the years, we have become a point of reference of this industry, serving important companies, like Ferrero, Barilla, McDonalds, Epta and Switzer group to name a few. From our customers’ feedback and industry trends we have conceived a new innovative professional refrigerator machine, easy to use, modern looking that will reduce Global Potential Warming (GPW), CO2 emissions by 30% and the energy consumptions by 60%, redefining in depth the standard machine, acting directly on the main components of it. Our project, called REFICIENT is looking ahead and is designed to directly address the upcoming legislations of F-Gases (N. 517/2014), mandatory from 2020, that acts on the fluorinated greenhouse gases, banning the use of R-507 gases, replaced by hydrocarbon refrigerants, like the R-290. This law creates a new market need and a high demand of innovative fridges throughout Europe. Our refrigerator is thought to deliver a highly adaptable commercial refrigerator, designed for lower energy consumption, with feedback & control capability and also built with eco-friendly, new generation material like the bio-polymer plastics. REFICIENT, will lead to long-term profitability for both customers and our company, providing a significantly lower running costs to our client, - 30% electrical costs (€1,954 per year), generating € 11 millions of accumulated profit by 2023 for TEKNA and 9 new positions.

Keywords: refrigeration,energy,efficient,global potential warming gpw,co2 emissions,legislations,fgases,hydrocarbon refrigerants,bio polymer plastics,pvc free
FOOD and Local, Agricultural, and Nutritional Diversity (FOODLAND)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive agri-food sector for a safe and healthy diet
Action type: Research and Innovation actions
Countries involved: Italy,Ethiopia,Uganda,Italy,Germany,Spain,Malta,Switzerland,Tunisia,Tanzania, United Republic of,Switzerland,Kenya,Denmark,Morocco,United Kingdom
Call: Food Systems Africa (H2020-SFS-2019-2, 2019)
Start date: 2020-09-01
End date: 2025-02-28
Duration (months): 54.0
Total project cost (EUR): 6999086.75
EU funding (EUR): 6999086.75
Participants: 29
Project status: SIGNED

FOODLAND aims at enhancing the diversity of food production and consumption in six African countries displaying different stages of the nutrition transition. To this end, FOODLAND will create a network of 14 local Food Hubs that will aggregate relevant actors and serve as injection points for the introduction of innovations. FOODLAND has identified specific objectives addressing the organizational, technological, and nutritional needs of the local African food systems to be reached during the four-year project duration: 1. to detect behaviour and preferences of consumers and producers, in order to customize innovations to local sensitiveness; 2. to develop and implement organizational innovations, aimed at boosting coordination among food operators; 3. to develop, test, and validate (open) technological innovations in laboratory and in the field; 4. to disseminate knowledge of solutions towards malnutrition reduction and innovations. Through participative approaches in the Food Hubs, FOODLAND will create and validate (TRL 5) 12 prototypes for crop and fish farming and food processing systems that will deliver 17 novel food products. FOODLAND will empower smallholder farmers and food operators, will foster nutrition-responsive and sustainable agro-biodiversity, will reinforce the productivity and resilience of food supply chains, and will create new market opportunities at both the local and global scales, thereby encouraging the flourishing of rural communities. These achievements will benefit both African and European consumers by providing them with traditional-based, healthy, nutritious foods, while encouraging the diffusion of African diets and aiding the fight against malnutrition, particularly in women and children.

Keywords: food,supply chain,food systems,malnutrition,dietary diversity,agro biodiversity,behaviour,technological randi,sustainability,gender,smallholder farmers,consumers,food processors,smes
Tetrapod limb ecomorphology inferring ecology during dinosaur-bird transition (Dino-Bird Ecology)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-06-01
End date: 2023-05-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Birds are the only extant dinosaurs and have achieved enormous diversity, spanning a wide range of ecologies including substantial variation in habitat use. However, ecological diversification in the earliest birds and their closest dinosaurian relatives is poorly characterised. This presents a fundamental knowledge gap regarding the dinosaur-bird transition – a major event in vertebrate evolution. The unparalleled Mesozoic Jehol and Yanliao fossil assemblages from China include most known Mesozoic birds and feathered non-avian dinosaurs, revealing unprecedented data on this remarkable transition. I will use cutting-edge 3D imaging methods to visualise the limb morphology in early birds and bird-like dinosaurs. We will quantitatively constrain the link between the foot/hand morphology and habit ecology using geometric morphometrics and finite element analyses based on a large 3D database of extant tetrapods. The results will be used to infer the habitat use (e.g. arboreal, terrestrial, aquatic) of important fossil species during the dinosaur-bird transition, with a focus on early birds and closely related dinosaurs. This will add considerably to understanding of palaeoecology during dinosaur-bird transition, and clarify contentious hypotheses of the origin of bird flight. Our findings will also provide a test of ecological explanations for the extinction of the enantiornithine birds, and the ultimate survival and success of Ornithuromorpha, which includes all extant birds. Hosted in a world-class palaeontology lab in Oxford and trained by a supervisor leading the quantitative macroevolutionary research, this proposal will bring cutting-edge 3D morphometrics and statistical comparative skills to the researcher, ensuring her a promising independent future career. The long-term connection between key institutes of UK and China built in this proposal will also benefit both countries in not only research profiles, but also in public engagement and education.

Keywords: tetrapoda,feathered dinosaurs,early birds,ecomorphology,mesozoic,jehol and yanliao biota
Establishing in-depth services enhancing the innovation management capacity of South West of France SMEs in 2017-2018 (MAGIC SWF SMEs 3)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: France,France
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 250527.5
EU funding (EUR): 250527.5
Participants: 8
Project status: CLOSED

The project involves 3 partners of the Enterprise Europe Network South West France consortium which covers the Aquitaine/Limousin/Poitou-Charentes region and the Midi-Pyrénées territory. The general objective is to contribute to raise the competitiveness of SMEs from this area by offering support services in the area of innovation management. The project will also contribute to develop more efficient and more effective innovation processes and higher quality innovation management capacity assessment and support services. The support will be delivered as service packages of 7 days to 2 groups of SMEs: a) Beneficiaries of the SME Instrument of Horizon 2020: to enhance the probability of a successful exploitation of the innovation project results and lead to the sustainable growth of the beneficiary beyond the participation in Horizon 2020. The support service will pinpoint weaknesses in the innovation capacities of the beneficiary, select suitable coaches to address the identified weaknesses and monitor the coach-client relationship and to accompany the beneficiary through the SME instrument project b) SMEs with significant innovation activities and a high potential for internationalisation: to enhance their innovation management capacities to be able to gain new international markets and leaderships. The support service will consist in an in-depth innovation assessment in order to develop and implement a tailored action plan to improve the SMEs capacity to manage innovation processes. The partners will use dedicated assessment tools: IMP3rove and Check’Innov. The project will last 24 months and will provide 84 support service packages.

Keywords: innovation management,sme instrument,sme support,funding,europe
Simulation-as-a-Service Tool for Industrial Furnaces Innovative Engineering Design (SaaStified) (SaaStified)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-11-01
End date: 2017-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Simulations based on the numerical solution of Partial Differential Equations (PDEs) are nowadays customarily being applied for the design of industrial products and plants, in several branches of the Computer Aided Engineering (CAE), such as thermodynamics, fluid dynamics, structural mechanics. The improvement of the mathematical modeling tools and the availability of computing power have dramatically enhanced the accuracy of computer based simulations, and hence the support they offer to engineering design process. Yet, due to their complexity, in most cases simulations are not fully integrated into the design workflow. Operations as preprocessing, grid generation, setting up and running the simulations, and postprocessing the outputs, require specific skills and are extremely time and resources consuming. For these reasons, design engineers are sometimes resorting to simplified low fidelity models, which are often quantitatively inaccurate. More complex and accurate high fidelity models are only and occasionally considered at the very end of the design cycle, and are usually employed to optimize single components or to provide a final assessment of the overall accuracy of the standard simpler models. In this background, introducing accessible high-fidelity models in a user friendly intermediate environment would represent a strategic asset to facilitate and spread simulation-based design approaches and their benefits for industries in new industrial applications, as already happens for example in automotive or aerospace industry, towards a more efficient resources employment, energy saving and optimized products. The objective of the project is to set up a user friendly high-fidelity simulation platform, based on efficient simulation techniques and standardized automated workflows to be provided as a Simulation-as-a-Service (SaaS) tool, for the design and optimization of industrial furnaces.

Keywords: simulation,saas,user friendly,reduced order modelling,combustion,uncertainty,quantification,melting furnaces,emission reduction,co2 reduction,energetic efficiency,raw materials,optimization
Convenient Access to Light Sources Open to Innovation, Science and to the World (CALIPSOplus)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Germany,Germany,Italy,Italy,Germany,Türkiye,Poland,Sweden,Switzerland,Jordan,France,France,France,Netherlands,Denmark,United Kingdom
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2016-1, 2016)
Start date: 2017-05-01
End date: 2021-10-31
Duration (months): 54.0
Total project cost (EUR): 9997538.88
EU funding (EUR): 9997538.88
Participants: 19
Project status: CLOSED

In the present project, CALIPSOplus, the relevant synchrotrons and free electron lasers in Europe and the Middle East join forces to contribute to the completion of ERA and to tackle the new challenges arising from the commitment of the EU to Open science, Open innovation and Open to the world. Integration with respect to user access, support, instrumentation, data analysis and data management is strongly pushed forward by this advanced community, looking back at a long tradition of integrated activities funded under FP6 and FP7, and largely profiting from the experiences already gained. The European Synchrotron and FEL User Organisation will be consolidated and the performance and use of the wayforlight portal as pivotal platform of the light sources community will be boosted. Data management of the different facilities will be harmonised and a data management plan for the CALIPSOplus consortium be defined. Particular focus will be on leveraging scientific excellence in EU-13 countries and on widening the use of light sources by users from these regions. This will be achieved by visits to universities in these countries, by dedicated schools and by an especially set-up Twinning programme. As a pilot action a specific Trans-national Access programme will be offered for users from SMEs, closely related to an awareness raising campaign for light sources use and the role of light sources as customers among local industry around the facilities. Joint Research Activities will focus on metrology of diffraction limited optics in collaboration with the manufacturing industry, of particular importance for the new hard X-ray free electron lasers as well as for the next generation synchrotrons, and on software tools for remote data analysis. Focusing on the horizon beyond 2020, established programmes and activities of the light source community will be evaluated with respect to their future importance and corresponding sustainability and business plans will be developed.

Keywords: synchrotron,free electron laser,light source,spectroscopy,diffraction,analytical facility,imaging,materials sciences,time resolved investigations,users,inclusion,research infrastructures
Multimodal spectral sensors and orchestrated deep models for integrated process optimisation (MULTIPLE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Spain,Spain,Spain,Spain,Italy,Italy,Germany,Spain,Spain,Greece,Belgium,Switzerland,Poland,France,France,Portugal
Call: Application driven Photonics components (H2020-ICT-2019-2, 2019)
Start date: 2019-12-01
End date: 2023-04-30
Duration (months): 41.0
Total project cost (EUR): 7368755.91
EU funding (EUR): 5719779.39
Participants: 20
Project status: SIGNED

MULTIPLE will develop cost-effective multimodal monitoring solutions with a breakthrough impact on production quality and efficiency. It will bring cutting-edge OLED-based sensors, snapshot hyperspectral filters and dual-aperture imaging to deliver cost-effective spectrometers and camera cores in a broad VIS/SWIR range, complemented with cost effective laser-based chemometric sensors in the MWIR. On top of these sensors, MULTIPLE will develop novel multimodal monitoring systems that will be IoT native, by combining them with cloud, big data, and deep learning for agile development and orchestration of complex AI-based models to optimize production improving EU manufacturing competitiveness. To develop cost-effective HSI SWIR (0.9-1.7 µm) camera cores ready for volume production. To develop a compact and cost-effective dual-aperture HSI imager combining snapshot CMOS and InGaAs hyperspectral sensors based on mosaic filters covering the whole VIS/SWIR range (0.4-1.7 µm). To develop novel cost-effective spectrometer solutions for highly specific chemometric analysis in an extended VIS/MWIR range (0.4-3.5 µm wavelength), based on innovative OLED sensors and laser-based spectroscopy. To develop embedded deep models for regression, classification and RT control. It will guarantee onsite and online measurements and classification of different types of categories with high flexibility, accuracy, and reliability. To develop an integral and scalable approach to process monitoring, quality assurance, and process optimization through the orchestration of photonic monitoring systems under an IoT native approach. The aim is to leverage SoA cloud and big data technologies to create new services and microservices enhancing decision support tools. To demonstrate MUTLIPLE in 3 manufacturing scenarios: steelworking, woodworking and food

Keywords: snapshot vis,swir hyperspectral imagers,laser based ir analysers,oled based spectrometers,multimodal spectral monitoring,cloud,deep learning,edge computing,orchestration,optimisation