Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reaching the effects of gastric bypass on diabetes and obesity without surgery (BYPASSWITHOUTSURGERY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Denmark,Denmark
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-01-01
End date: 2023-06-30
Duration (months): 78.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 1911072.36
Participants: 2
Project status: SIGNED

Gastric bypass surgery results in massive weight loss and diabetes remission. The effect is superior to intensive medical treatment, showing that there are mechanisms within the body that can cure diabetes and obesity. Revealing the nature of these mechanisms could lead to new, cost-efficient, similarly effective, non-invasive treatments of these conditions. The hypothesis is that hyper-secretion of a number of gut hormones mediates the effect of surgery, as indicated by a series of our recent studies, demonstrating that hypersecretion of GLP-1, a hormone discovered in my laboratory and basis for the antidiabetic medication of millions of patients, is essential for the improved insulin secretion and glucose tolerance. But what are the mechanisms behind the up to 30-fold elevations in secretion of these hormones following surgery? Constantly with a translational scope, all elements involved in these responses will be addressed in this project, from detailed analysis of food items responsible for hormone secretion, to identification of the responsible regions of the gut, and to the molecular mechanisms leading to hypersecretion. Novel approaches for studies of human gut hormone secreting cells, including specific expression analysis, are combined with our advanced and unique isolated perfused gut preparations, the only tool that can provide physiologically relevant results with a translational potential regarding regulation of hormone secretion in the gut. This will lead to further groundbreaking experimental attempts to mimic and engage the identified mechanisms, creating similar hypersecretion and obtaining similar improvements as the operations in patients with obesity and diabetes. Based on our profound knowledge of gut hormone biology accumulated through decades of intensive and successful research and our successful elucidation of the antidiabetic actions of gastric bypass surgery, we are in a unique position to reach this ambitious goal.

Keywords: gut hormones,incretin hormones,glp 1,gastric bypass,diabetes,obesity,enteroendocrine cells
Homeostatic balancing of excitation and inhibition in vivo (HomeoBalanceExcInh)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-10-01
End date: 2021-09-30
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Balanced excitation and inhibition is a fundamental principle of neural circuit function, and perturbed excitation/inhibition (E/I) balance has been linked to diseases such as epilepsy, autism and schizophrenia. Maintaining E/I balance within normal bounds depends in part on homeostatic plasticity, in which neurons compensate for deviations in activity levels by adjusting their responsiveness to excitation and inhibition. Yet despite recent progress in elucidating molecular mechanisms underlying homeostatic plasticity in reduced preparations, little is known about such mechanisms in the intact brain. I propose to address this gap using a simple and genetically tractable neural circuit that I recently characterized. In Drosophila, Kenyon cells (KCs), the neurons underlying olfactory associative memory, receive excitation from projection neurons (PNs) as well as feedback inhibition from a single identified neuron (‘APL’). The balance between these two forces maintains sparse odour coding in KCs, which enhances the odour-specificity of associative memory by reducing overlap between odour representations. Preliminary evidence indicates that KCs adapt to prolonged disruption of E/I balance, providing a ground-breaking opportunity to use the powerful genetic tools of Drosophila to uncover the molecular mechanisms underlying homeostatic balancing of excitation and inhibition in vivo in a defined circuit that mediates a sophisticated behaviour. Specific aims: 1. Characterize homeostatic plasticity in the PN-KC-APL circuit. 2. Identify genes up- and down-regulated in response to perturbations of E/I balance. 3. Determine role of candidate genes and cellular mechanisms in homeostatic plasticity. Establishing the PN-KC-APL circuit as a novel model system for homeostatic plasticity will reveal for the first time the molecular mechanisms underlying homeostatic balancing of excitation and inhibition in the intact brain.

Keywords: olfaction,sparse coding,homeostatic plasticity,balance of excitation and inhibition,olfactory memory
Scaling-up NCD Interventions in South East Asia (SUNI-SEA)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Indonesia,Slovakia,Netherlands,United Kingdom,United Kingdom,Viet Nam
Call: Global Alliance for Chronic Diseases (GACD) - Scaling-up of evidence-based health interventions at population level for the prevention and management of hypertension and/or diabetes (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 3992625.0
EU funding (EUR): 3992625.0
Participants: 10
Project status: SIGNED

The SUNI-SEA project aims to validate effective scaling-up strategies of evidence-based diabetes and hypertension prevention and management programmes, and to enhance sustainable action for the achievement of the Sustainable Development Goals, based on experiences in South-East Asia. The burden of non-communicable diseases (NCDs), such as hypertension and diabetes, is increasing in low- and middle-income countries. Indonesia, Myanmar and Vietnam have national or large-scale evidence-based programmes to prevent diabetes and hypertension, detect people at risk and treat patients. By creating synergies in financing (health insurance and public funding), use of international standards (WHO-PEN protocols and local guidelines), community involvement (individuals and groups) and use of ICT (different apps), the three countries link NCD prevention and control to poverty alleviation and social security. Within these excellent living labs, the consortium will apply a comparative effectiveness research with a participatory approach – research with people, not on people. The project will define the critical success factors for scaling-up hypertension and diabetes prevention and management measures by validating a) the contextual factors for effective and efficient implementation; b) the core components of community-based and health facility-based interventions; c) the most cost-effective and sustainable scaling-up strategies. The project will create training and learning materials, draw lessons learned from these three countries and provide a cost-effective implementation and scaling-up model for worldwide implementation of NCD interventions. Through engaging all stakeholders, SUNI-SEA will contribute to the Global Alliance for Chronic Diseases evidence base that can be used to implement strategies for improving global health.

Keywords: upscaling,non communicable diseases,effectiveness,cost benefit analysis,sustainability policy,lmic,community,primary health care,participatory approach
Assembly Tooling for the Fast Rotorcraft Project (ASTRO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Spain
Call: Compound Rotorcraft Assembly Tooling (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2022-02-28
Duration (months): 48.0
Total project cost (EUR): 712500.0
EU funding (EUR): 498750.0
Participants: 2
Project status: CLOSED

The objective of the project is to get a complete set of assembly and maintenance tooling, including auxiliary tooling. Due to the tight tolerances required in aeronautical industry, Some assembly jigs will be equipped with an optical structured light measure system that will allow the set up of the tooling and the position verification of the parts during assembly with tolerances equal or under 0.1 mm. The use of this kind of systems are spearhead in the field of precision measurement and the advantages against currently measurement systems, as laser tracker, will be shown in following paragraphs. In addition, optical systems are becoming the preferred measurement systems in automatized assembly jigs which will be the step forward in the aeronautical assembly lines.

Keywords: assembly tooling,maintenance tooling,structured light
The Bible and the Law in Carolingian Europe: Scriptural Exegesis and Royal Legislation from Charlemagne to Charles the Bald (ca. AD 780-880) (BIBLACE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-01
End date: 2018-11-01
Duration (months): 18.0
Total project cost (EUR): 119595.6
EU funding (EUR): 119595.6
Participants: 1
Project status: CLOSED

In what ways did the Bible shape the formation of political communities in early medieval Europe? This project studies the impact of biblical models on royal legislation in the Carolingian period (ca. AD 780-880). It proposes a new approach to the study of the intersection between religion and politics in a formative period of European history, during which crucial institutional and conceptual resources for the development of political and religious community, statehood and law were created. Under the Carolingian rulers from Charlemagne onwards, we can observe a steady increase of biblical quotations in legal texts issued by the ruler or by assemblies of lay and clerical advisers (so-called royal ‘capitularies’ and conciliar decrees). Biblical prescriptions and prohibitions were either directly integrated into legal norms or used to justify the establishment or modification of norms. To understand this convergence between biblical law and royal legislation, the rich material of Carolingian biblical exegesis is of crucial importance, since it provides access to the concepts and interpretative traditions associated with specific biblical texts in the minds of contemporaries. Authors and readers of exegetical commentaries were often at the same time advisers to kings and important political decision makers, and also involved in the drafting of legislative texts. The project thus proposes a comparative study of legal and exegetical texts and of their dynamic relationship. It has a twofold objective: first, to analyse the concrete impact of biblical models upon Carolingian society, and the ways in which they were used to (re)define its legal and moral framework; second, to understand the ‘social life’ of Carolingian biblical commentaries, both as a spiritual and intellectual endeavour and as a social and political practice.

Keywords: carolingian europe,history of law and legislation,bible in the early middle ages,biblical exegesis,political theology
Global Alliance for Chronic Diseases Secretariat (GACD)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Coordination and support actions
Countries involved: United Kingdom
Call: Grant to the Global Alliance for Chronic Diseases (H2020-IBA-SC1-GACD-2018, 2018)
Start date: 2019-08-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 240000.0
EU funding (EUR): 240000.0
Participants: 1
Project status: CLOSED

The Global Alliance for Chronic Diseases (GACD) brings together leading health research funding agencies of key countries to coordinate research activities addressing on a global scale the prevention and treatment of chronic, non-communicable diseases such as cardiovascular diseases, diabetes, respiratory diseases, cancer and mental health. The GACD Secretariat supports its member agencies by helping to align research priorities, coordinating joint funding opportunities and maintaining a Research Network which aims to increase the impact of funded research projects.
Providing services under Horizon 2020 enhancing the innovation management capacity of Hungarian SME's within the framework of the Enterprise Europe Network - 2019 (INNO-HUN2019)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Hungary,Hungary,Hungary,Hungary,Hungary,Hungary,Hungary,Hungary
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 74152.5
EU funding (EUR): 74152.5
Participants: 9
Project status: CLOSED

The global objective of the "Providing services under Horizon 2020 enhancing the innovation management capacity of Hungarian SME's within the framework of the Enterprise Europe Network - 2019" project is to effectively contribute to the innovation driven competitiveness and sustainable growth of the European economy via improving the innovation management processes and culture of Hungarian SMEs by enabling them to get their products, services successfully into the market. The concept of this project focuses on the development of Innovation Management capabilities via two different types of high-added value services: • “Key Account Management” for the beneficiaries of the SME Instrument, Future and Emerging Technologies Open (FET-Open) and Fast Track to Innovation (FTI) programs • “Enhancing SME innovation management capacity” with the usage of IMP3rove and Innovation Health Check tools/methods. Partners delivering services are members of the Hungarian Consortium for Enterprises (HCE). Their in-depth innovation management portfolio will be accessible for SMEs from all parts of the country.

Keywords: enterprise europe network,horizon 2020,key account management,enhancing sme,innovation management capacity,sme instrument,imp3rove
The Resurgence in Wage Inequality and Technological Change: A New Approach (CBTC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Israel
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-09-01
End date: 2021-08-31
Duration (months): 60.0
Total project cost (EUR): 1495091.0
EU funding (EUR): 1495091.0
Participants: 1
Project status: SIGNED

Social-science explanations for rising wage inequality have reached a dead end. Most economists argue that computerization has been primarily responsible, while on the other side of the argument are sociologists and political scientists who stress the role of political forces in the evolution process of wages. I would like to use my knowledge and experience to come up with an original theory on the complex dynamics between technology and politics in order to solve two unsettled questions regarding the role of computerization in rising wage inequality: First, how can computerization, which diffused simultaneously in rich countries, explain the divergent inequality trends in Europe and the United States? Second, what are the mechanisms behind the well-known observed positive correlation between computers and earnings? To answer the first question, I develop a new institutional agenda stating that politics, broadly defined, mitigates the effects of technological change on wages by stimulating norms of fair pay and equity. To answer the second question, I propose a truly novel perspective that conceptualizes the earnings advantage that derives from computerization around access to and control of information on the production process. Capitalizing on this new perspective, I develop a new approach to measuring computerization to capture the form of workers’ interaction with computers at work, and build a research strategy for analysing the effect of computerization on wages across countries and workplaces, and over time. This research project challenges the common understanding of technology’s role in producing economic inequality, and would thereby significantly impact all of the abovementioned disciplines, which are debating over the upswing in wage inequality, as well as public policy, which discusses what should be done to confront the resurgence of income inequality.

Keywords: rising wage inequality,class politics,politics of production
From CO2, Water and Sunlight to Valuable Solar Fuels: Tracking Reaction Intermediates in Solar Fuel Generation with Ultrafast Spectroscopy for More Efficient Catalysis (CO2 Intermediates)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Fundamental understanding of the catalytic chemistry and underlying mechanisms in carbon dioxide (CO2) reduction is an urgent need for efficient solar energy conversion from CO2, water and sunlight to valuable carbon-neutral fuels that urgently need to replace our fossil fuel-based economy of today. This proposal focuses on unraveling the reaction mechanisms of the reduction of CO2 in aqueous photoelectrochemical (PEC) systems in order to allow innovative development of more efficient chemistry for the production of solar fuels based on the understanding of the underlying mechanisms. We propose to study the catalytic cycle of photo-driven CO2 reduction on earth-abundant and non-toxic materials with state-of-the-art transient absorption (TAS) and transient infrared spectroscopy. The combination of these techniques will open up groundbreaking opportunities to monitor reaction intermediates on the relevant timescales of charge transfer to form the reaction product. First, selectivity of the catalyst will be tuned with the deposition of sub-nanometer oxide layers by atomic layer deposition (ALD) – a technique with a precision of down to one atomic monolayer. Then, the selective reactions will be studied in detail by TAS and transient IR spectroscopy. With the outstanding expertise of the host professors Prof. Durrant and Prof. Hamm (secondment) and my broad and profound expertise in photoelectrochemical systems and ALD, this project is expected to have a high success rate despite its challenging nature. With a better understanding of CO2 reduction processes, the design of more efficient catalytic systems will advance this renewable technology and facilitate its scale-up and commercialization. Finally, through this project I will not only expand my technical and scientific skills but also develop and strengthen my managerial skills to become a leading independent researcher in the field of solar energy conversion.

Keywords: co2 reduction,intermediates,transient absorption spectroscopy,transient ir spectroscopy,atomic layer deposition,catalysis,photocatalysis,photoelectrochemistry
Microtubular solid oxide fuel cells Finally In MicroScale (FIMS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Estonia
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 154193.28
EU funding (EUR): 154193.28
Participants: 1
Project status: SIGNED

A breakthrough in economically viable efficient energy conversion has been long waited, with fuel cell technology being a promising candidate. Recently, tubular Solid Oxide Fuel Cells (SOFCs) have received increased attention due to possibility to shorten start-up times, reduce material losses and lower costs of fuel cells. In order to reach sufficient volumetric power density, decrease working temperature and reduce costs, the diameter of the SOFC tubes has to be reduced at least an order of magnitude, compared to state of the art (at or above 1 mm). In the recent years, the hosting group of the project has demonstrated fabrication of yttria-stabilized zirconia (YSZ) microtubes with diameters <100 µm and tested their viability for use as an electrolyte in microtubular SOFCs. The FIMS project is focused on innovative development of controllable YSZ microtube fabrication methods and subsequent use of the microtubes in construction of a SOFC stack to prove commercial potential. A method for fabrication of optical quality fluorescent microtubes with controlled dimensions (diameter <100 µm, wall thickness 5-10 µm) and facile structural defect detection with optical techniques will be realized. Porous electrode deposition on the microtubes will be refined and a microtubular electrolyte supported pilot SOFC stack will be constructed and characterized. The target of FIMS is to promote transfer of knowledge through training and career development of the Fellow in the multidisciplinary field of SOFC technology, in order to re-enforce professional maturity and independence of the Fellow. Two secondments – academic and industrial – further improve the training and collaboration network of a young scientist. The project will have positive impact on the Fellow's career progress towards becoming a leading researcher, and supports enhancement of environmental protection and sustainable resource use.

Keywords: sofc,microtubular sofc,fluorescence in metal oxides,sol gel