Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Next Generation Microbiome Platform (FlexiBiome)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Switzerland
Call: Dedicated support to biotechnology SMEs closing the gap from lab to market (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-04-01
End date: 2018-07-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

PharmaBiome AG is an ETH Zurich spin-off company that was established in February 2015 after intense scientific interactions at ETH Zurich between highly qualified scientists and business professionals in the fields of biotechnology and gastroenterology. We envisioned a huge interest of the pharmaceutical industry in microbiome-based technologies. Our primary target market focuses on patients suffering from recurrent Clostridium difficile infections (rCDI), which are usually a consequence of antibiotic use. Almost 900.000 cases of CDI in the EU and USA may occur each year bringing the acute-care direct costs of CDI to an estimated 4.5 billion € in 2008. The treatment consists of intestinal communities from faeces of healthy donors (Faecal Microbiota Therapy, FMT). However, FMT is not standardized as the contents that are present in the human stool vary from individual to individual and change over time. Moreover, there are safety concerns associated with FMT such as the transmission of the pathogenic microbes from improperly screened and handled stool. FMT is also associated with the need for a healthy donor in every case. FlexiBiome will bring to the market a standardized therapeutic mixture of living intestinal bacteria as an alternative to FMT. Our innovation represents a safe (of a defined composition, clear mode of action), efficient (same functionality as FMT but using a controlled delivery), flexible (production is controlled, the product is storable and we will provide access to large markets) and targeted therapeutic to fight rCDI. Flexibiome will be 50 % cheaper than FMT therapy.

Keywords: living intestinal bacteria,clostridium difficile infections rcdi,faecal microbiota therapy replacement,healthy microbiota
Culturally Inclusive Schools: Celebrating diversity, teaching common values and fostering intercultural competence among youth (INCLUDed)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: SIGNED

Despite the successes achieved in studying how intercultural competence of young people can be promoted in European school systems, different stakeholders indicate that considerable gaps remain in understanding “what works” in promoting intercultural competence in youth. The proposed project “Culturally Inclusive Schools: Celebrating diversity, teaching common values and fostering intercultural competence among youth” (INCLUDed) responds to this need by addressing three main limitations in existing knowledge and research in the European context: a) The lack of rigorous empirical studies aimed at conceptualizing and measuring intercultural competence in youth; b) The lack of rigorous empirical studies aimed at conceptualizing and measuring culturally inclusive educational approaches promoted by schools; c) Insufficient evidence on the effectiveness of different culturally inclusive educational approaches promoted by schools for the development of intercultural competence of youth. A heuristic framework inspired by educational effectiveness and ecological systems theory is applied to a large nationally representative sample of young people (14-year-olds) in a European country (i.e. Italy) and analyses are carried out to: a) Develop, adapt and validate a multifaceted measurement instrument of intercultural competence; b) Develop, adapt and validate a multifaceted measurement instrument of classroom cultural diversity climate based on student perceptions of their learning environments; c) Evaluate the relationship between different configurations of classroom cultural diversity climate approaches and the intercultural competence of youth and to examine the effectiveness of these approaches in different cultural school settings and for specific subgroups of young people. The project will generate actionable evidence for research, educational policy and practice adding significantly to current research on interculturality in culturally diverse school settings.

Keywords: intercultural competence,classroom climate,citizenship education,educational effectiveness
A neural network based counterfeit detection system to verify the authenticity of products (Microguard)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Counterfeiting is a crime, involving the manufacturing or distribution of goods under someone else's name, and without their permission. Counterfeit goods are generally made from cheap and lower quality component that put the health and safety of consumers at risk. According to an International Chamber of Commerce the total value of counterfeit and pirated goods globally is around €1.77 trillion. Each year EU companies lose €83 billion in sales due to counterfeited products. Although the counterfeiting has been a problem for decades, there is no solution yet for it fighting at consumer level. Cypheme introduces a counterfeit detection system that allows a consumer to determine if a product is an original branded product using only a cell phone camera. The system uses a micro structured varnish that can only be read with a neural network technology developed by Cypheme to authenticate the product. The system can be applied directly on the product, making it harder for counterfeiters to copy. During the feasibility assessment, a minimum viable product will be defined, a go-to-market strategy and a supply chain will be established, as well as further development plan will be drafted. Within the overall innovation project, Cypheme aims to adapt the varnish application to metal, glass and plastic and upscale the neural recognition software; optimize the user interface for brand owners and consumers; perform a quality demonstration and validation of the system at different goods.

Keywords: neural network,machine learning,counterfeit,anti counterfeit,varnish,microstructure,brand protection,security
Metamorphosis as a re-set mechanism of the ageing clock: is early-life stress bypassed by morphogenesis? (METAGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-18
End date: 2022-02-14
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The overall aim of this proposal is to understand how early-life stress can affect later ageing biomarkers (oxidative stress, telomere shortening, and telomerase activity) in species with complex life-cycles, and in particular to test the completely new hypothesis that amphibian metamorphosis may act to rejuvenate tissues previously exposed to stress. The research objectives are: 1) to determine whether levels of ageing biomarkers vary across larval and metamorphic stages, 2) to investigate whether damage accumulated by larvae due to early-stress is reduced by metamorphosis and whether this differ between remodelled and newly formed tissues/structures, and 3) to examine whether early-stress influences cellular responses stressors to ageing biomarkers later in life. I will be trained by the host to adopt an empirical approach to measuring early-life stress and ageing (e.g. oxidative stress, telomere length, and telomerase activity) in species with complex life-cycles (using as a model Xenopus laevis individuals), and will learn new skills in several areas of animal physiology and molecular biology, which are needed to successfully complete the research objectives. This training will increase my experience in different biological domains and will help me to develop my independent research group in the EU.

Keywords: early life stress,development,oxidative stress,telomeres,complex life cycles,amphibians,metamorphosis
Conformational Shift Inducers (CSI): An atomistic level investigation of Aurora kinase A (AurkA)–MYC interaction and its distortion by CSI compounds (CSI AurkA-MYC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

In recent years, remarkable advances in cancer research and treatment have been made. Still, little progress is observed in the treatment of specific solid tumours, e.g. hepatocellular carcinoma. The oncoprotein MYC is frequently involved in the genesis and maintenance of human solid tumours and therefore represents a highly promising drug target. Unfortunately, as MYC does not withhold any potential binding cavities for druglike small-molecules, it has been long considered as an undruggable protein. Recently, however, a potential way to target this oncogene indirectly via Aurora kinase A (AurkA) was introduced. When bound to MYC, AurkA shields it from proteasomal degradation. Specific AurkA inhibitors that are conformational shift inducers (CSIs) prevent MYC binding to AurkA, finally leading to MYC’s proteasomal degradation. This type of inhibition holds a great promise for indirectly targeting MYC. However, the precise mechanism of AurkA–MYC binding is unknown and it is unclear what the most important characteristics of a CSI compound in preventing this protein–protein interaction are. These uncertainties are currently the limiting step in the compound design process and hinder the ongoing drug development. To this end, this research project aims to characterize and study the AurkA–MYC interaction and CSI compounds’ binding to AurkA by long-timescale all-atom molecular dynamics (MD) simulations. The main objectives of this research are to understand the AurkA–MYC interaction on the molecular level and to provide a mechanistic explanation of why the CSI compounds prevent the MYC binding. As a result, this research will guide the design and development of CSIs and thus may provide therapeutic possibilities for cancers with inadequate treatment options. Finally, this will establish a new way to utilize MD simulations in drug discovery and design that may be transferred to other potential drug targets in future.

Keywords: protein protein interaction,cancer,drug discovery,inhibitor,allosteric effect,molecular dynamics,protein kinase,aurka,solid tumour
ULTIMATE: indUstry water-utiLiTy symbIosis for a sMarter wATer society (ULTIMATE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Protection of the environment, sustainable management of natural resources, water , biodiversity and ecosystems
Action type: Innovation actions
Countries involved: Germany,Italy,Italy,Spain,Spain,Spain,Israel,Germany,Spain,Italy,Belgium,Norway,Greece,Greece,Greece,France,France,France,Czechia,Netherlands,Netherlands,United Kingdom,United Kingdom,Denmark,Denmark,United Kingdom
Call: Building a water-smart economy and society (H2020-SC5-2019-2, 2019)
Start date: 2020-06-01
End date: 2024-10-31
Duration (months): 53.0
Total project cost (EUR): 16614813.75
EU funding (EUR): 13527116.27
Participants: 30
Project status: SIGNED

ULTIMATE will act as a catalyst for “Water Smart Industrial Symbiosis” (WSIS) in which water/wastewater plays a key role both as a reusable resource but also as a vector for energy and materials to be extracted, treated, stored and reused within a dynamic socio-economic and business oriented industrial ecosystem. We adopt an evidence-based approach anchored on 9 large-scale demonstrations across Europe and SE Mediterranean relevant to the agro-food processing, beverages, heavy chemical/petrochemical and biotech industries. We recover, refine and reuse wastewater (industrial and municipal) but also extract and exploit energy (combined water-energy management, treatment processes as energy producers, water-enabled heat transfer, storage and recovery) and materials (nutrient mining and reuse, extraction and reuse of high-added-value exploitable compounds) contained in industrial wastewater. We support the cases and ensure their replicability through smart tools to optimize and control, assess costs and benefits, minimize risks and help stakeholders identify, assess and explore alternative symbiotic pathways linked to emerging business opportunities, supported by tailored contracts and investment schemes. ULTIMATE nurtures partnerships between business (incl. industrial and technological ecosystems), water service providers, regulators and policy makers and actively supports them through immersive Mixed Reality storytelling using technology and art to co-produce shared visions for a more circular, profitable, socially responsible and environmentally friendly industry, with water at its centre. The project mobilises a strong partnership of industrial complexes and symbiosis clusters, leading water companies and water service providers, specialised SMEs, research institutes and water-industry collaboration networks, and builds on an impressive portfolio of past and ongoing research and innovation, leveraging multiple European and global networks to ensure real impact.

Keywords: water smart industrial symbiosis,circular economy
KOALA FOCUS: A disruptive e-health approach to treat at home, attention deficits without drugs (KOALA FOCUS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Attention Deficit with/without Hyperactivity Disorders (ADHD) is a neurological disorder with a high societal impact: 2.5 M children are diagnosed, and 2-5 M Adults in Europe are non-diagnosed. 50% children are not medicated mainly due to drug refusal and high rate under medication face adverse effects and treatment rejection. Mensia has developed a revolutionary prototype, Mensia KOALA, to treat ADHD by means of neurofeedback at home and without drugs, using Artificial Intelligence techniques. Our new prototype version “KOALA Focus” aims to be the first affordable Gold Standard Medical Device for Precise Medical Neurofeedback friendly used at home, whatever the patient's age. Our prototype, currently at TRL6, is a breakthrough innovation thanks to disruptive combination: at home evidence based medical neurofeedback technology, the first reliable non-invasive and precise e-Health Digital Therapeutic, monitoring and treating various types of ATTENTION DEFICITS. Our business model is based on buy hardware cap via secured eHealth Mensia platform and pay per at home session. The ADHD therapeutic market is estimated to reach €21.5 B by 2024 growing at a CAGR of 6.2%. TOTAL ATTENTION DEFICIT market in Europe worth 5 M individuals. KOALA Focus, once validated by the appropriate clinical trials, can achieve up to 50% of regular prescribers from this addressable market in the EU. Mensia aim to set up a Gold Standard of Good Clinical Practices for Precise Medical Neurofeedback at home, capturing 20% (1 M individuals) of this addressable market: 2,5 M children EU + 2,5 M adults. We estimated that in 5 years (end of Phase 2 project), we will accumulate ~€120 M of Revenues at 40€ /session, accounting for ~5% of the EU market, earning ~€36M profit (ROI of 5.7), while hiring 60 new technical and sales employees.

Keywords: attention deficit and hyperactivity disorders,adhd,attention deficit,neurofeedback,precise medicine,home medicine,digital therapeutic,machine learning,decision making,computer algorithms
Uranium isotope fractionation: a novel biosignature to identify microbial metabolism on early Earth (UNEARTH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-09-01
End date: 2023-02-28
Duration (months): 66.0
Total project cost (EUR): 1998971.0
EU funding (EUR): 1998971.0
Participants: 1
Project status: CLOSED

Prokaryotes (archaea and bacteria) are the most abundant form of life both at present and throughout paleohistory and exhibit exquisite metabolic diversity, unmatched by eukaryotes. On early Earth, the absence of atmospheric oxygen led to the emergence of anaerobic microbial metabolisms such as methanogenesis, sulfate reduction, iron reduction, and denitrification. Non-isotope and isotope tools used to study ancient microbial life have provided evidence for each of these types of metabolisms in the rock record. However, there remains much uncertainty and debate regarding this evidence, primarily because of confounding effects of abiotic processes, and ambiguity in interpretation of isotopic signatures. This proposal aims to develop a robust biosignature for microbially mediated reduction reactions, that, in conjunction with existing tools, provides insight into ancient microbial activity in the rock record and establishes temporal constraints on the emergence of specific metabolic groups. To this end, I propose to use uranium (U) as an isotopic biosignature for microbial life. This pursuit is driven by recent work in my laboratory that has revealed a readily resolved difference between the isotopic signatures of enzymatically reduced uranium and abiotically reduced uranium. Combined with the ability of most microbial metabolic groups to catalyze U reduction, this finding raises the tantalizing possibility that uranium isotopic fractionation could serve as a biosignature for specific metabolic groups in the rock record. The establishment of a robust, bulk universal isotopic biosignature would be valuable to paleontologists, astrobiologists, and geologists because it would provide direct insight into the timing of emergence of specific metabolisms in ancient sedimentary environments on Earth.
Sonarc - The world's first full audio frequency range, massless speaker technology platform, providing immersive and powerful sound from a smaller size. (Sonarc Speaker)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Sonarc Innovations have created the world’s first full audio range speaker technology without any moving parts, providing clarity immersive and power sound from a smaller size whilst reducing manufacturing costs and complexity. Sonarc Innovations are targeting the €17Bn home audio market, with the ambition of becoming the new standard in speaker driver technology, providing precisely controlled panels of micro speaker devices for the accurate creation of immersive, high spatial resolution sound environments, allowing listeners to experience a richer and realistic sound, when compared to today's bulky, low spatial resolution speaker technology. Sonarc Innovations is applying for the Horizon 2020 programme under the ‘Innovation in SME’s’ SMEInst-01-2016-2017 Open Disruptive Innovation Scheme phase 1, the overall objective for this innovation project is to bring to market a novel and inventive speaker technology with industrial applications (as stated in the written opinion of PCT international patent search authority August 2017 on Sonarc technology) superseding existing speaker driver technology across a wide range of user applications from immersive audio to portable devices. Revenue from licensing/partnership APT for specific applications will finance ongoing EU based innovation at Sonarc Innovations, enabling the creation of high value, knowledge based employment. This will allow the EU to stay at the forefront of this emerging and expanding technological field and area of research. Sonarc Innovations will focus on the development of new and innovative commercial applications for the APT, including miniaturisation for portable and mobile devices, creation of omnidirectional and directional products, optimization of existing technology around power efficiency and sound power levels and the continued growth of the IP underpinning APT.

Keywords: full audio frequency range,massless speaker technology,plasma,immersive sound,directional sound