Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Focused ultrasound and microbubbles targeting alpha-synuclein pathology-related dementia (FUMA) (FUMA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

Over half of Parkinson Disease patients develop cortical dysfunctions leading to Parkinson Disease Dementia (PDD). The cognitive changes are primarily driven by pathological alpha-synuclein (a-syn) protein aggregates with secondary synaptic dysfunctions in the cortex. Microglia plays a key role in synapse maintenance and clearance of aggregated a-syn proteins, however, this is impaired in PD. Low intensity focused ultrasound (FUS) combined with intravenous microbubbles (MB) can non-invasively increase the permeability of the blood-brain barrier, resulting in a transient and controlled entry of blood-born substances. In animal models of Alzheimer disease, FUS-MB treatments increase microglial-mediated clearance of extra- and intracellular protein aggregates and improve synapse health. In small patient cohorts in the clinic, FUS-MB treatments are safe and results suggest decreased levels of pathological proteins in Alzheimer disease patients. HYPOTHESIS: FUS-MB applications targeted to the cortex promote cortical a-syn clearance and synapse maintenance which can prevent or slow the development of dementia in PD. In a mouse model of PDD we will determine the ability of FUS-MB treatment to increase microglial-mediated clearance of a-syn, maintain synapse health, and inhibit the development of cognitive dysfunctions. In addition, we aim to evaluate non-invasive positron emission tomography and magnetic resonance imaging as biomarkers of the effects of FUS-MB treatment. Finally, we will investigate the underlying pathway of potentially beneficial effects of FUS-MB treatments by measuring changes in specific pathways of interest as well as perform an unbiased screen for novel targets. Both the researcher and supervisor have a background in Parkinson disease research. The researcher brings expertise in FUS-MB treatments of mouse models and the supervisor is an expert in preclinical and clinical neuromodulation, the latter with FUS.

Keywords: focused ultrasound,blood brain barrier,alpha synuclein,microglia
Reconstructing the environmental, biological, and societal drivers of plague outbreaks in Eurasia between 1300 and 1900 CE (Synergy-Plague)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Norway,United Kingdom,France
Call: ERC Synergy Grants (ERC-2023-SyG, 2023)
Start date: 2024-04-01
End date: 2030-03-31
Duration (months): 72.0
Total project cost (EUR): 8381928.0
EU funding (EUR): 8381928.0
Participants: 7
Project status: SIGNED

Synergy-Plague is a multi-disciplinary project to bring our knowledge and understanding of plague, past and present, to new heights. Focussing on the environmental, biological, and societal aspects of plague outbreaks in Eurasia between circa 1300 and 1900 CE, it will address four main questions: (1) Why/how did plague re-emerge in 14th century Central Asia? (2) Why/how did plague re-occur and spread in Eurasia after the Black Death? (3) Why/how did clinical and demographic patterns of plague infection differ across space and time? (4) Why/how did plague disappear from Europe and the Middle East in the 18th and 19th centuries? Our project is based on the hypothesis that plague waves and clinical differences resulted from unique alignments of multiple events: environmental (climatic and soil-chemical), biological (from individual to ecosystem) and societal (demographic, socio-economic and political). Four PIs from the natural sciences and humanities, together with their team members, will jointly study how plague re-emerged in 14th century Central Asia and radiated repeatedly from Eurasian wildlife reservoirs in the following centuries, only to disappear in the 18th-19th centuries. We will develop and analyse new dendrochronological and (paleo-)soil data, textual documentary evidence, and epidemiological models. To understand how plague reached and spread in human populations, paleo-environmental and historical data together with relevant experimental work will be combined with statistical and mathematical modelling. To appreciate why clinical signs and mortality rates varied in space and time, historical evidence will be examined together with new entomological data and ancient DNA (aDNA) of historical plague strains (from humans and anthropophilic rodents). Synergy-Plague will revolutionise our understanding of plague and contribute to our ongoing struggle with epidemic diseases, present and future.

Keywords: black death,plague pandemics,rodent burrow systems,human and rodent ectoparasites,plague reservoirs,soil properties,past cimate,epidemiology,statistical and mathematical modeling,experimental work
Health Economic Policy Analysis with Real World Data (HEPARD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Germany,Norway,Netherlands,Sweden,Romania,Switzerland
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2025-11-01
End date: 2029-10-31
Duration (months): 48.0
Total project cost (EUR): 3593270.16
EU funding (EUR): 3593270.16
Participants: 13
Project status: SIGNED

The HEPARD (Health Economic Policy Advice with Real World Data) Doctoral Network addresses persistent health inequalities across Europe through a multidisciplinary approach uniting health economics, public health, and advanced data analytics. Despite positive trends in general health and life expectancy, disparities—particularly among socioeconomic groups and regions—continue to challenge policy efforts. HEPARD aims to train researchers in causal inference methods, using observational data to evaluate the real-world impacts of health policies and interventions. HEPARD focuses on key drivers of health disparities. Through interdisciplinary research clusters, it investigates the effects of lifestyle interventions, family-centered policies, and health insurance systems on health equity. Traditional studies often overlook socioeconomic and contextual factors shaping policy outcomes. HEPARD instead uses quasi-experimental and machine learning methods to analyze real-world data, yielding insights more relevant to Europe’s diverse conditions. The network’s research program includes four main work packages (WPs): - Real Data Innovation Analytics: Applies machine learning and causal inference to assess lifestyle health interventions in reducing chronic disease. - Family Futures: Studies health policies’ impacts on parents and children, focusing on policies like postpartum support and childcare across diverse European context. - Incentives and Impacts: Examines how various health insurance systems affect equity and access across Europe. - Methodological Cross-Breeding for Enhanced Causal Inference: Develops new causal inference tools by integrating economic and epidemiological approaches. Together, these WPs create a unified framework for understanding and addressing health inequities, combining methodological innovation with policy relevance to equip early-stage researchers with the tools to design impactful, evidence-based solutions that enhance well-being across Europe.

Keywords: health economics causal inference policy evaluation social disparities methodological innovation
Buddhism’s Early Spread to Tibet: Dunhuang and the Influence of Sinitic Scriptures (BEST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2499809.0
EU funding (EUR): 2499809.0
Participants: 1
Project status: SIGNED

Modern scholarship follows emic accounts in situating the origins of Tibetan Buddhism squarely in India, tacitly accepting Tibet’s claim to be heir to the orthodox tradi-tion. This oversimplifies the complex history of Buddhism’s two transmissions to Tibet, in the 7th and 11th centuries, elid-ing the formative early contributions of Sinitic sources, principally imparted from the Silk Road oasis of Dunhuang, a crucial locus of interaction between Tibetan and Chinese cultures in the 8th-11th centuries. Manuscripts preserved in the Dunhuang caves evidence this Sino-Tibetan nexus in native compositions and translations from Chinese into Tibetan. Efforts to trace Chinese and Sino-Tibetan influences on the formation of Tibetan Buddhism have been largely impressionistic, but state-of-the-art tools such as Handwritten Text Recognition to digitize manuscripts allow their systematic analysis, and others permit us to identify “fingerprints” of Tibetan translations from Chinese. BEST will locate scriptures and other materials of Sinitic origin, and trace their impact on Tibetan Buddhism. Starting with an examination of the reasons for the prominence of Dunhuang, we will uncover the conditions permitting the site to become such a multicultural center, cradle to a high level of Buddhist scholarship. Identifying Sinitic sources introduced into Tibet in the early period, we will probe their later importance, challenging the tradition's polemical historiography which represses such recognition. We will produce a historical study addressing the background of Dunhuang's scholastic Buddhist culture, studies of individual Tibetan translations from Chinese, linguistic studies of the Chinese-Tibetan lexical interface, studies on the most prominent Dunhuang monk-translator, Chos grub, investigations of later Tibetan historiographical works, and a database of Tibetan Dunhuang manuscripts, all contributing to a fundamental revaluation of formative influences on early Tibetan Buddhism.

Keywords: buddhism,tibet,dunhuang,sino tibetan contact
UTILIZING IOT-SYSTEMS FOR DECENTRALIZED PRODUCTION CONTROL AND OFFERING SURPLUS PRODUCTION CAPACITIES ON A PRODUCTION PLATFORM (assemblean)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Germany
Call: Women TechEU (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-06-01
End date: 2022-11-30
Duration (months): 6.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

assemblean is an automation and production technology company emerging from years of research in the field of decentralized production control. Xiaojun Yang and Alexander Pöhler investigated the question of how to increase the utilization of production facilities. It became apparent that many production capacities remain unused. During this research at the Heinz Nixdorf Institute of the university of Paderborn, we developed a decentralized production control system, with which existing production systems can be equipped. These control systems then communicate with each other in order to subsequently take over production control automatically. This leads to significant improvements in production processes. In addition, the production control systems identify free capacities automatically. assemblean wants to use these capacities and make them available to other companies. For this purpose, a Production-as-a-Service platform was also developed. With this on-demand production platform products can be built completely digitally. The wide range of production processes and services enables us to offer to handle the entire supply chain of the products, from purchasing raw material and standard parts to manufacturing, assembly and shipping. assemblean has received a grant of 565.000 €. This has been used to develop both products, the decentralized production control and the production platform, until we founded assemblean GmbH in march of this year. Xiaojun Yang and Alexander Pöhler co-founded assemblean. Our startup has grown into an eight-person team. Four full-time employees and four student assistants contribute expertise from the fields of mechanical engineering, industrial engineering and IT. Both founders have already gained start-up experience through starting and building up an e-commerce GmbH operating throughout Europe.

Keywords: production platform,industry 4 0,decentralized production control
The Building Guilds of Interwar Europe: An Experiment in Economic Democracy (ECODEM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 2
Project status: CLOSED

In the aftermath of the First World War, European cities witnessed a massive expansion of producer cooperatives in the building sector. Drawing on ideas for industrial reform that were shared widely across borders, these producer cooperatives, or building guilds, aimed to not only improve urban housing, but also democratize the construction industries and society more broadly. Local cooperatives quickly merged into national associations that promoted distinct models of collective decision-making and shared ownership. By the early 1920s, pan-European federations had started to distribute information and organize exchange between construction cooperatives that stretched the entire continent. Despite their rapid growth and initial success, however, the construction cooperatives of interwar Europe have been virtually forgotten. ECODEM offers the first comprehensive historical analysis of this transnational movement. Focusing on England, Germany, and Spain, the action has the following four objectives. First, it will reveal the democratization measures that were implemented to improve participation on the shop floor, at the work site, and in management. Second, it will show what urban vision this trade union movement formulated, and how this vision compares with the urban vision of architect, planners, and municipal officials, which have received far more attention in scholarship. Third, ECODEM will investigate under what conditions employees accepted measures aiming at rationalization, even if those measures had negative consequences for labor. And fourth, it will analyze the factors that determined success and failure of construction cooperatives in distinct national settings. By studying a forgotten yet highly popular trade union movement, ECODEM not only advances scholarship in Labor and Urban History as well as the interdisciplinary scholarship on economic democracy, but it also contributes to debates in the wider public about the future of work and urban housing.

Keywords: labor history,urban history,interwar europe,trade unions,economic democracy,history of housing
Photorhabdus Action for Grapevine Protection (PhotorActVine)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,Chile
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 250643.4
EU funding (EUR): 250643.4
Participants: 2
Project status: SIGNED

The fanleaf virus nematode, Xiphinema index, is the Grapevine Fanleaf Virus (GFLV) vector, the leading cause of the most severe viral disease in grapevines worldwide. By feeding on the root tips of actively growing grapevines, nematodes can cause a 40% root mass loss, facilitating the acquisition and transmission of GFLV and significantly reducing crop yield —up to 80%— and grape quality. Currently, no direct control methods are available for these intracellular pathogens, so management efforts focus on monitoring and controlling the fanleaf virus nematode using hazardous chemical pesticides. There is an urgent need for innovative control strategies that enhance vector management, mitigate the impact of intracellular pathogens, and improve viticultural sustainability worldwide. The cosmopolitan endosymbiont Photorhabdus (Morganellaceae) bacteria produces a wide range of natural compounds with multiple functions in the soil. PhotorActVine hypothesized that Photorhabdus strains might potentially protect grapevine plants against the fanleaf virus nematode and its global damage while also being capable of colonizing grapevine roots and enhancing the plants' growth and defence mechanisms. PhotorActVine proposes an innovative, ambitious, and feasible project, which includes i) identifying Photorhabdus strains with the highest nematicidal ability, ii) training these bacteria to adapt to grapevine rhizosphere conditions, iii) reducing the damage caused by fanleaf virus nematode and its damage through the application of evolving Photorhabdus strains in the grapevine roots, and iv) identifying the mechanisms involved in the interaction between Photorhabdus and grapevine plants. This multidisciplinary approach will enhance and integrate our understanding of the efficacy and mechanisms of Photorhabdus strains in grapevine protection, contributing to sustainable viticulture and providing insights into the broader application of these novel microbial biocontrol agents.

Keywords: photorhabdus entomopathogenic bacteria biological control agent,bacteria plant interaction fanleaf virus nematode xiphinema index grapevine fanleaf virus gflv sustainability grapevines
Science, Society and Environmental Change in the First Millennium CE (SSE1K)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Switzerland,United Kingdom,Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1998963.0
EU funding (EUR): 1998963.0
Participants: 4
Project status: SIGNED

In the Mediterranean in the first millennium CE, environmental and climatic changes have been identified as causes for significant short- and long-term societal and political processes and events, such as epidemics and the rise and fall of empires. However, the effects of environmental or climatic variation on humans are substantially more complex than a narrative of causation of major events, since culturally specific perceptions and interpretations of environmental or climatic variation can have significant social, religious or political implications. SSE1K builds on state-of-the-art research but goes beyond it to ask novel, important questions about relationships between past societies and environmental / climatic fluctuation. The project will pioneer an approach which is both multi- and interdisciplinary, centring on these questions: How did humans experience and perceive environmental and climatic variation across the Mediterranean in the first millennium CE, and how did they respond both intellectually and socially to these changing conditions? SSE1K addresses issues which have been raised as significant challenges for collaborative study of climate change but have yet to be fully addressed: it will investigate how the circulation of knowledge and adaptability intersect with sustainability and resilience in pre-modern societies, and how human perceptions and ways of thinking shaped societal, political or religious responses to environmental / climatic change. The project will integrate textual, archaeological and environmental evidence to investigate a large geographical area (the Mediterranean) at a scale which balances human lived experience and climate trends (the first millennium CE) over macro- and micro-levels. This integration is crucial in producing a holistic picture of past knowledge, resilience and sustainability, and will change the ways that scholars understand the relationships between past humans and environmental / climatic fluctuation.

Keywords: environmental history environmental archaeology historical climatology history of science intellectual culture climatology and climate change
WIRE 26 - FUTURE REGIONS: THE ROLE OF SUSTAINABLE INNOVATION IN EUROPEAN COMPETITIVENESS (FUTURE REGIONS)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Other Widening
Destination: Other Widening
Action type: Coordination and support actions
Countries involved: Ireland
Call: Presidency conferences with a European regional dimension - WIRE 2026 (HORIZON-WIDERA-2025-WIRE2026-IBA, 2025)
Start date: 2026-01-01
End date: 2027-04-30
Duration (months): 16.0
Total project cost (EUR): 345000.0
EU funding (EUR): 250000.0
Participants: 1
Project status: SIGNED

The "Week of Innovative Regions in Europe" (WIRE) is a leading European policy forum focused on innovation and regional development. It is a key event where policymakers, regional authorities, research institutions, and businesses gather to discuss research and innovation practices, challenges, and opportunities across European regions. The event also enables stakeholders to address, develop and progress key topics of interest to the community and explores current and future EU funding programs related to research and innovation. The Technological University of the Shannon (TUS), in partnership with regional stakeholders, proposes to host the WIRE 2026 conference, on the 2nd and 3rd of December 2026, as an official event of the Irish Presidency of the Council of the European Union (July - December 2026). Under the theme “Future Regions: The role of sustainable innovation in European competitiveness”, WIRE 2026 will co-create strategies for sustainable regional growth, showcase regional success stories and innovations from across Europe, facilitate knowledge exchange between EU institutions, regional actors, and Horizon Europe projects and strengthen collaborative policy development aligned with the EU Green Deal and smart specialisation strategies (S3). WIRE 2026 will be a two-day, high-level in-person event (with live streaming of keynote speaker events), hosted at the TUS Moylish Campus, in Limerick, Ireland and will convene European policymakers, innovators, academics, SMEs, and citizens to: Strengthen the regional dimension of competitiveness and innovation by aligning local action with EU priorities: Position regional actors as co-leaders in addressing global challenges: climate, security, decarbonisation, and technological transitions. Build momentum toward cohesive, inclusive, and resilient Europe Provide actionable insights and policy outcomes Build upon the outcomes of previous conferences in the WIRE series

Keywords: innovative regions,wire,policy,development