Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Embedded electronically steerable satcom airborne antenna (E2S2A2)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Israel,Bulgaria
Call: Integrated airborne antenna for satellite communications in wing – fuselage airframe fairing (H2020-CS2-CFP02-2015-01, 2015)
Start date: 2016-07-01
End date: 2022-03-31
Duration (months): 69.0
Total project cost (EUR): 1749624.75
EU funding (EUR): 1223162.0
Participants: 3
Project status: SIGNED

E2S2A2 includes the design, prototyping, manufacturing and testing "on ground" and "in-flight" of an airborne antenna highly integrated into the wing – fuselage airframe fairing. Allowing high data rate in-flight connectivity (IFC) for different purposes. The connectivity will be through satellite communication operating at the Ka frequency band. The antenna is electronically steered utilizing Phased Array technology. This allows the high integration into the airframe structure, concretely the wing-to-fuselage fairing (WFF) panels of the FTB2 prototype aircraft (A/C). The panels will be replaced by new composite structures with embedded antenna elements. The antenna builds on concepts and prototypes developed by Gilat and its Bulgarian subsidiary Raysat and will benefit from the vast experience in SATCOM technology and airborne applications. The antenna consists of innovative Monolithic Microwave Integrated Circuit (MMIC) resulting from RTD partially funded by national RTD programs. The activities and 69 months' work plan are in accordance with the work plan of the Regional Aircraft FTB2 demonstrator. Close synchronization, coordination and cooperation with the Leader is vital. The work is divided into 6 technological WPs starting with the Definition of Structure and System Conceptual Design (WP1). WP2,3 include the activities from design to qualification of the Embedded Steering Antenna Aperture and KRFU unit (WP2) and the Ka Data Network Unit (WP3). The SATCOM MODEM selection and modifications will be carried through WP4. The SATCOM Ka band Antenna System Integration Activities at Laboratory level included in WP5. Integration into the A/C and ground and in-flight testing in WP6. WP0 is project management including close synchronization with the Leader and reporting and interfacing with the EC. Dissemination and Exploitation activities in WP7. The project will allow high data rate IFC minimizing effects on the A/C aerodynamic, performance and fuel consumption.

Keywords: airborne,satellite communication,electronically steerable antenna,clean sky,composite materials
Itinerant Cultural Agents in Early Modern Europe and the Scotsman Thomas Seget: A Case-Study (AGENTSEGET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-09-07
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

AGENTSEGET is an interdisciplinary project that will explore a neglected type of intellectual who grew to prominence in Europe at the end of the sixteenth century, a time of significant social and cultural upheaval. The religious conflicts, political tensions, and profound intellectual transformations of the decades around 1600 called for new styles of communication often involving subterfuge, middle-men, and disguise. A different type of intellectual was required to connect scholars in different and often troubled areas of Europe. Their task was to deliver scientific instruments, precious books and manuscripts crucial to the production of new knowledge and theories. To support themselves, they also traded information about princes, governments, religious factions and political machinations. The project will focus on the Scotsman Thomas Seget (1569/70-1627), one of the most interesting and less studied examples of this type of intellectual. By using Seget as a case study, AGENTSEGET aims to unlock the rich and vibrant personal and professional network of intellectual brokers and cultural middlemen in which prominent scientists such as Kepler and Galileo operated and thrived, exchanging ideas and receiving informal feedback on their work. The findings of AGENTSEGET are expected to demonstrate that cultural and scientific mobility has always been an essential component of the circulation and development of cutting-edge scientific research. The results will be disseminated through a monograph, Open Access publications, an interactive website, an edited volume, an exhibition, and a series of educational activities.

Keywords: scientific revolution,cultural agents,intellectual networks,cultural mobility,thomas seget,galileo galilei,johannes kepler,justus lipsius
Toward monolithic CMOS based neural probes for stable chronic recording and brain machine interfaces (ChroMOS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

The recent advent of active high-density implantable neural probes based on CMOS technology is a big leap forward in neuroscience. Unprecedentedly, these new probes provide simultaneous access to several thousands of single-neurons in different brain circuits. Although realized with different circuit’s architectures, such devices combine the use of standard CMOS and MEMS technologies to realize monolithic active dense probes that integrate into the same substrate hundreds of closely spaced microelectrodes together with electronic circuits for recording extracellular bioelectrical signals. However, despite their unique value, current CMOS-probes are not yet adapted for chronically stable implants and this is a major drawback both for neuroscience research as well as for growing potential clinical applications in fields such as brain-machine-interfaces or neuroprosthetics. An emerging hypothesis to minimize tissue-reactions and improve chronic stability of implantable probes consists in downscaling the cross-sectional sizes of their shafts as well as the overall system size. This fellowship proposes a deep study of this hypothesis by exploiting key advantages of monolithic CMOS based neural probes together with the optimization of circuits, materials and microfabrication processes. I will exploit my background in MEMs technologies and acquire new expertise in neuroscience to evaluate solutions for reducing CMOS shanks dimensions (20-80 µm width, 15-30 µm thick), strategies to improve tissue-materials interfaces, and to assess the effects of these features on brain tissue responses and recording performances. This will lead to ChroMOS probes with a very thin and uniform width (tens of microns) through all the shaft, and with electrode densities up to 1000 sites/mm2. This can lead to remarkably stable probe’s implants with large-scale single-neuron recording capabilities, far behind current technologies.

Keywords: active dense implantable neural probes,micro systems,microelectrodes,neuroengineering,foreign body reactions,single neuron large scale recordings
An Optical Quasicrystal for ultracold atoms (Quasicrystal)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 1499086.0
EU funding (EUR): 1499086.0
Participants: 1
Project status: CLOSED

During the last fifteen years, ultracold atoms in optical lattices have emerged as a powerful model system to study the many-body physics of interacting particles in periodic potentials. The main objective of this proposal is to extend this level of control to quasiperiodic potentials by realizing an optical quasicrystal. Quasicrystals are a novel form of condensed matter that is non-periodic, but long-range ordered. They have first been observed in the 1980s by Dan Shechtman in diffraction experiments. Quasicrystals give rise to a pattern of sharp Bragg peaks, similar to periodic crystals, but with rotational symmetries that are impossible for periodic structures. Their structure was found to be given by aperiodic tilings with more than one unit cell, such as the celebrated Penrose tiling. Even though quasicrystals are long-range ordered, many foundational concepts of periodic condensed matter systems such as Blochwaves or Brillouin zones are not applicable. This places them on an interesting middle ground between periodic and disordered systems and highlights their potential for novel many-body physics. We will first characterize the optical quasicrystal using Kapitza-Dirac diffraction, and then study their unusual transport properties and relaxation dynamics after quantum quenches in the presence of interactions. We will additionally look for interesting novel phases at strong interactions and investigate the topological properties of quasiperiodic potentials. Building on my substantial expertise with optical lattices, I thus plan to build a versatile quantum simulator for the physics of quasicrystals by combining a non-periodic optical potential with ultracold Rubidium and Potassium gases.

Keywords: optical lattice,quasicrystal
Towards the discovery of cellular RNA-binding proteins with master regulatory roles in virus infection (vRNP-capture)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: United Kingdom
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-12-01
End date: 2026-11-30
Duration (months): 60.0
Total project cost (EUR): 1999916.0
EU funding (EUR): 1999916.0
Participants: 1
Project status: SIGNED

RNA is a central molecule for RNA virRNA is a central molecule for RNA virus infection. However, viral genomes encode very few proteins that are able to interact with viral RNA. Hence, viruses co-opt cellular RNA-binding proteins (RBPs) to support infection. The host cell also employs RBPs to combat viruses through the recognition of unusual signatures present viral RNAs. Despite these critical roles, the complement of cellular RBPs involved in infection remains largely unknown. This research programme aims to discover comprehensively and unbiasedly the repertoire of cellular RBPs endowed with master regulatory roles in virus infection. To achieve this, we will exploit a novel method developed in my laboratory, named viral RNA interactome capture (vRIC), that allows the elucidation of viral ribonucleoprotein (RNP) composition with unprecedented depth and specificity. It employs pulse-labelling of viral RNA with a photoactivatable nucleotide analogue, UV crosslinking, viral RNA purification with antisense probes and quantitative proteomics. (Aim 1) I hypothesise that cellular RBPs that interact with a broad-range of viral RNAs are likely endowed with master regulatory roles in infection. To test this, I will apply vRIC to cells infected with different RNA viruses to discover RBPs that are shared across viral RNPs. Moreover, we will employ interferon α to investigate if the engagement of these RBPs with viral RNA is regulated by the antiviral state. (Aim 2) To test if these broad-spectrum RBPs display master regulatory roles in infection, I will apply a novel functional screen using genetically modified cells and a broad library of fluorescent viruses. (Aim 3) We will then decipher the molecular mechanisms underpinning the ability of these RBPs to support or restrict infection. In summary, this innovative research programme will discover cellular RBPs with master regulatory roles in infection with great potential as targets for broad-spectrum antiviral therapies.

Keywords: rna binding proteins,virus,ribonucleoprotein,interferon,immunity,proteomics,transcriptomics,iclip
Vertical Sky, the next generation wind turbine for sustainable, silent and decentralized energy production. (Vertical Sky)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Global population’s growth is set to increase to 9.8 B people by 2050 . This raises concerns regarding the energy demand as more and more energy and food will be needed. Energy production currently mainly relies on fossil sources, which will soon be depleted and seriously threaten the environment. Sustainable wind energy production represents a valid potential alternative, but is still either centralised or inefficient, thus not providing energy with a desirable continuity and capacity. This causes waste of resources and considerable risks of shut downs. Moreover, the loudness and death of birds and bats on the blades causes a lower integration of these solutions. AWP introduces Vertical Sky, the only vertical axis wind turbine for distributed and sustainable energy production. Thanks to the unique and proprietary pitch angle control system, Vertical Sky provides 3-fold noise reduction, 90% bird and bats death reduction, 25% easier transportation and 15% easier installation. This, along with the improved efficiency (0.47, comparable to large turbines) and power range (0.75-1.5MW), makes Vertical Sky the perfect solution for sustainable and decentralised energy production close to residential areas. AWP enables energy self-production makes energy available for anyone, anywhere. During the phase 1 feasibility study,AWP will establish a sound go-to-market strategy and supply chain, and will draft further development plans. During the second phase of the innovation project, AWP will perform engineering optimisation activities and validate the commercial potential in a pilot trial at a partner's facility before introducing the technology on the market.

Keywords: sustainability,decentralized energy,energy efficiency,wind energy,local energy production,machine learning algorithm,smart control system
Breaking new ground for soil restoration: function and fate of core beneficial microbial consortium coated by pyrogenic carbon (FIREMAN)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Czechia
Call: Widening Fellowships (H2020-WF-02-2019, 2019)
Start date: 2020-09-27
End date: 2022-09-26
Duration (months): 24.0
Total project cost (EUR): 156980.64
EU funding (EUR): 156980.64
Participants: 1
Project status: CLOSED

One of the most challenging tasks in ecology is to reclaim landscapes being disturbed by anthropogenic activities. Many human endeavours have been put forth for improving microbial activities and their structures, soil organic carbon level and plant reestablishment after depleting the top earth. Global use of pyrogenic carbon shows promising prospect on C sequestration and soil restoration, but there is a noticeable delayed advancement in improving its benefits. In accordance to UN Climate Smart Agriculture and UN Sustainable Development Goals, this project will seek a novel strategy for soil restoration by using pyrogenic carbon and core microbial communities (CBMs), to gain multiple benefits including aspects of waste management, C sequestration and plant regeneration. The project will make use of unique habitats for CBMs selection at both a long-term natural successional post mining site and a well-recorded reclaimed meadow in Czech Republic, Central Europe. The main objective of this project is to assess if pyrogenic carbon could ensure the function of CBMs during their transplantations from donor to recipient soils: 1) disentangle the ‘refuge’ effect of pyrogenic carbon on CBMs from macro-fauna by isotopic analysis, and microbial oxidation effect on pore structures and hydrophobicity of pyrogenic carbon, and 2) clarify the compositions of CBMs and their functions to responsive plant species in undeveloped soils. The transfer of knowledge between the host institution and the candidate will pave a solid way for the researcher’s scientific career, and future collaborations between the researcher, the host and the secondment are foreseen. Altogether, this project will provide a promising potential to increase the competitiveness of EU in using bio-wastes and soil inoculants for circular economy by bridging in waste management and soil restoration.

Keywords: pyrogenic carbon,thermal pyrolysis,core micorbial communities,inoculation,plant soil feedback,faunal grazing,sequencing,c sequestration
PulseHaler™: A Novel Treatment Device for COPD. (STOP-COPD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-02-01
End date: 2022-07-31
Duration (months): 42.0
Total project cost (EUR): 3449093.75
EU funding (EUR): 2414365.63
Participants: 1
Project status: CLOSED

Chronic Obstructive Pulmonary Disease (COPD) is a progressive, debilitating, disease of the lungs which affects 50M Europeans and kills 160,000 every year, with an annual cost burden of €141B. Respinova Ltd. has invented a novel device, called PulseHaler™, to treat COPD in a revolutionary way by opening the small airways, which are known to collapse in COPD patients thereby making it increasingly difficult to breathe. No other COPD treatment in the market today can effectively open the small airways. In a clinical trial, the PulseHaler™ was shown to substantially improve the functional capabilities and quality of life of COPD sufferers. If PulseHaler™ can reduce costs by the same magnitude to which it has been demonstrated to improve patient’s exercise capacity (the strongest predictor of morbidity and mortality), the current cost burden of COPD in Europe could be reduced by up to €21B annually. After winning a SMEi-1 grant and receiving a Seal of Excellence certificate for our first SMEi-2 application, we intend to complete several actions which will bring the PulseHaler™ to the commercial market in this SMEi-2 project. The design of the device will be finalized incorporating features and functions identified in our successful SMEi-1 project. We will then prepare the PulseHaler™ for large scale manufacturing. We will test the PulseHaler™ in a clinical study of COPD patients across several sites, to gather additional efficacy and usability data identified by KOLs in SMEi-1 as important to support uptake of the product in the market. We will continue to develop our reimbursement strategy for initial markets, finalize distribution arrangements in those markets, obtain regulatory approval, and proceed to launch the PulseHaler™. Respinova Ltd. is a 10 year old SME based in Israel with 7 employees. We have a seasoned management team with decades of combined medical device, business and leadership experience.

Keywords: chronic obstructive pulmonary disease,respiratory disease,lung disease,medical device,airway constriction,small airways,loss of lung function
Refined invariants in combinatorics, low-dimensional topology and geometry of moduli spaces (REFINV)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1996023.0
EU funding (EUR): 1996023.0
Participants: 1
Project status: SIGNED

Some invariants appearing in low-dimensional topology and algebraic geometry admit a so-called refinement: a much stronger, but more complicated invariant. For instance, in low-dimensional topology we study the Poincare polynomial of the triply-graded Khovanov-Rozansky homology of a knot, which is a refined version of the HOMFLY-PT polynomial. The usual Poincare polynomial and the E-polynomial of a character variety are refined by the full mixed Hodge polynomial. On the cohomology of a moduli space of Higgs bundles, we need an extra filtration, the so-called perverse filtration, to define the refinement. Where classical invariants produce polynomials in one variable q, and often have expressions involving Schur polynomials, refined invariants produce polynomials in two variables q and t, and often have expressions involving Macdonald polynomials. The connection conjectures and the P=W conjecture relate refined invariants appearing in the three contexts above. We propose to develop a comprehensive theory connecting these notions, and as main applications, to solve the P=W conjecture for character varieties, the Gorsky-Negut-Rasmussen conjectures relating knot invariants and sheaves on the Hilbert scheme, Cherednik's conjectures computing homologies of algebraic links via DAHA, the Hausel-Letellier-Rodriguez-Villegas conjectures computing mixed Hodge polynomials of character varieties, nabla positivity, and the Stanley-Stembridge positivity conjectures. To achieve our goal, we will build on methods developed in our previous work on the solution of the shuffle conjectures, the computations of homology of torus knots and Poincare polynomials of character varieties, and the proof of the curious hard Lefschetz conjecture. These methods include combinatorics of Dyck paths, symmetric functions and Macdonald theory, the A(q,t) algebra, cell decompositions of character varieties, natural actions on cohomology and K-theory, counting geometric objects over finite fields.

Keywords: moduli of vector bundles,character varieties,invariants of knots and 3 manifolds,symmetric functions,macdonald polynomials,hilbert schemes,enumerative geometry,mixed hodge theory