Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A continuous milk disinfection system for calf feeding on-farm (MilkGuard)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-09-01
End date: 2021-02-28
Duration (months): 30.0
Total project cost (EUR): 1521592.5
EU funding (EUR): 1065114.75
Participants: 2
Project status: CLOSED

The problem: Dairy farms are continuously aiming at increasing milk yield per cow in the herd. Calf early life nutrition dictates their development. Farmers feed a variety of liquid feeds including milk and milk replacers. The state-of-the-art method to reduce the risk of disease spread while feeding milk is to pasteurize it. Though natural milk is the ideal nutrition for calves, the need for pasteurization represents an additional cost for farmers. Importantly, on-farm pasteurized milk may still contain measurable amounts of bacteria and the overall procedure is time- and energy-demanding, which hampers wide application amongst small and medium dairy farms. The solution: We at Calvex have developed the milkGUARD solution, which enables the safe employment of optimum nutrition for calves, i.e. natural milk, free of pathogens. The milkGUARD solution combines state-of-the-art methods for fast killing of pathogens in natural milk. In a three-stage continuous process it disinfects milk with an efficacy of >99.99%. By providing a system that avoids indirect heating elements and works in continuous, we expect to reduce the operating costs to dairy farmers when treating milk for calf-feeding, offering 77% net savings when compared to conventional on-farm pasteurizers. The market: Milk is the EU's main agricultural product in terms of value – approx. 15% of agricultural output – with 160 million tonnes of cow’s milk produced in 2014. The EU milk processing industry is a pillar of the European economy, which contributes positively to the EU trade balance, bringing over €10 billion surplus. The implementation of the innovation project will place Calvex in a strong position to exploit a market potential over five years exceeding €83 million.

Keywords: milk disinfection,calf feeding,energy efficiency,water efficiency
Open Research Biopharmaceutical Internships Support (ORBIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Ukraine,Germany,Finland,Poland,Slovenia,Poland,Poland,Czechia,United States
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-03-01
End date: 2023-08-31
Duration (months): 66.0
Total project cost (EUR): 2268000.0
EU funding (EUR): 2268000.0
Participants: 14
Project status: SIGNED

The current process of drug development is lengthy and inefficient. Only 1 out of approximately 10,000 drug molecules enters the market. Therefore more effective medicines, demanded by society, cannot be provided by pharmaceutical industry. To fill this gap, Open Research Biopharmaceutical Internships Support (ORBIS) proposes that the high attrition rate of new drug candidates might be reduced by over 20% by improving early stage R&D productivity. The overarching objective of ORBIS is therefore to form an international and inter-sectoral academic and industrial network. The action is aimed at improving the preclinical pathway of medicine development concentrating on processes and technologies. The goal is to integrate multidisciplinary research by involving academia and industry from EU (Poland, Ireland, Finland, Germany and Czech Republic), EU associated country (Ukraine) and US to address the poor drug bioavailability as 70% of actives have solubility and/or membrane permeability problems. The action is addressed at selected molecules of class II and IV of Biopharmaceutics Classification System, to improve their pharmaceutical potential. The complementary consortium comprises experts in computations, physical chemistry, material science, nanotechnology, pharmacy, pharmacology and bioanalysis. The secondments will create a stimulating environment for early stage researchers to advance their individual career and soft skills. EU scientists will amalgamate their expertise in drug synthesis and dissolution, oral formulations, and bioanalytical methods with the knowledge on dermal research provided by the US partner. ORBIS will consolidate the existing links, promote long-term cooperation and exchange of knowledge between beneficiaries and partners. ORBIS will also enhance dissemination of new research outcomes and raise the awareness among the general public of the importance of drug delivery research that makes new drugs more accessible and affordable for society.

Keywords: medicinal chemistry,preformulation,pharmaceutical technology,drug delivery,dosage forms,processability,biorelevant dissolution,biomedical analysis,biopharmaceutics,technology transfer
Substrate import at work: single-molecule studies of ABC transporters (SM-IMPORT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany,Netherlands
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-09-01
End date: 2021-06-30
Duration (months): 70.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 500000.0
Participants: 2
Project status: CLOSED

ABC (ATP Binding Cassette) transporters represent the most abundant and diverse family of transport proteins known that play crucial roles in numerous cellular processes. Despite their importance, all proposed molecular models for transport are based on indirect evidence due to the inability of classical biophysical and biochemical techniques to directly visualize dynamic structural changes. To solve this problem, I suggest a novel approach that can decipher the molecular mechanisms of transport, with the ultimate goal to use this knowledge against pathogenic bacteria, for treatment of ABC-related diseases or multi-drug resistance of cancer cells. I propose to use single-molecule fluorescence microscopy for the study of conformational states of an ABC model system in vitro, and thus to observe directly how elementary transport steps are coordinated. This will open up a virtually unexplored biophysical research area and provide a detailed understanding of the molecular mechanisms of ABC transporters. The key questions of this proposal are: Aim 1: What is the mechanism of substrate binding in ABC transporters? The conformational equilibrium (open vs. closed state) of ABC-associated substrate-binding proteins will be studied to understand the molecular mechanism of binding, i.e., induced fit vs. conformational selection. Aim 2: What are relevant conformational states and changes for substrate translocation? The time- and length-scales of conformational changes in transmembrane and nucleotide binding domains as well as interactions with other domains will be characterized using the osmoregulator OpuA as a model system. Aim 3: How are substrate binding, energy utilization and translocation coordinated in ABC transporters? Finally, a complete model of transport will be developed to decipher the coordination of transport events, i.e., how substrate binding and ATP-hydrolysis are coupled and transferred into conformational changes that drive substrate transport.

Keywords: abc transporter,single molecule studies,f rster resonance energy transfer,fluorescence microscopy
Parkinson's disease: does it all start with gut inflammation? (PD-GUT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany,France
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-12-01
End date: 2026-11-30
Duration (months): 60.0
Total project cost (EUR): 1999722.5
EU funding (EUR): 1999722.5
Participants: 2
Project status: SIGNED

Burgeoning evidence shows that Parkinson's disease (PD) involves the gut before affecting the brain, leading to the fascinating hypothesis that the gut might be the site of disease initiation. Remarkably, the gut origin of PD is still poorly understood. Multiple triggers could serve as a first insult: infections, dysbiosis, and inflammatory bowel diseases (IBDs). All these conditions ultimately converge on intestinal inflammation. Thus, an intriguing hypothesis is that PD is a systemic illness that originates from an inflammatory insult in the gut. This hypothesis is based on the observation that genetic traits relevant for both sporadic and familial PD also modulate immune responses to enteric pathogens and confer risk to IBDs. To dissect shared mechanisms among these seemingly unrelated diseases, I envision a multi- and interdisciplinary project with a unique integration of competences in neuroscience, immunology, and microbiology. Moving beyond the state of the art, I will combine patient stem cell-derived organoid, organ-on-a-chip, and single-cell sequencing approaches to decode the role of intestinal inflammation in PD and to identify new mediators of immune cell contributions to neurodegeneration. Specifically, I will i) mechanistically dissect cell type-specific host immune responses to intestinal pathogens and their link to PD; ii) establish complex human pluripotent stem cell-derived intestinal organoids to investigate intestinal inflammation; and ii) implement patient multiorganoid platforms to identify key players in the communication between the inflamed gut and the brain. Unveiling the critical steps that initiate PD may lead to a conceptual leap forward in our understanding of how the gut affects the brain in both health and disease. The novel methodologies that will be developed will also lay the foundations for future interventions aimed at targeting intestinal inflammation in enteric and neurological diseases.

Keywords: parkinson s disease,innate immunity,intestinal inflammation,induced pluripotent stem cells,organoids
Calibration of Astronomical Spectrographs with Stabilized Fabry-Perot Etalons (STABLE_FABRY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-15
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

The “holy grail” of exoplanet research today is the detection of an Earth-like planet in the habitable zone of a Sun-like star. Doppler spectroscopy is an indispensable tool for finding and characterizing extrasolar planets; however, detecting an Earth twin by measuring the radial velocity (RV) perturbation it imposes on the parent star requires nearly one order of magnitude better RV precision than the best current spectrographs provide. A key component in addressing the limitations of existing instruments is the development of extremely precise calibration light sources that can be used to track drifts and imperfections of the spectrograph, removing them from the science data. A stable, reliable, and relatively inexpensive calibrator solves a “chicken and egg” problem in the field – motivating the building of more stable spectrographs, secure in the knowledge that they will be able to perform to their potential. Project STABLE_FABRY consists of developing a novel calibration technique that can be applied to a wide range of high resolution spectrographs. This technique uses a broadband Fabry-Perot etalon to provide the calibration spectrum; the etalon is stabilized by referencing it to an atomic transition using standard laser spectroscopy methods. Our preliminary work already indicates that a stability of 3 cm/s can be reached with this method, making it precise enough for detection of Earth-like planets. The only other currently available calibration technology with demonstrated precision at that level is the laser frequency comb, which is an order of magnitude more complex and significantly more expensive. Our technique can easily be adapted to different echelle spectrographs in the visible and near infrared by simply using an etalon optimized for that particular spectrograph. Developing this concept into an observatory-ready system will present a major breakthrough for high precision spectrographs, enabling detections of Earth twins with Doppler spectroscopy.

Keywords: astronomical spectrographs,extrasolar planets,precision measurements
Evaluating the performance of local climate policies in Mexico (2009-2018) (eLection)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Climate policy has been under negotiation at international level for more than twenty years. During this period, mitigation efforts and studies on implementation and governance of climate policy have focused on industrialised countries, paying little focus to emerging economies. Recently domestic laws have started to be enacted worldwide stemming from this international debate. In this context, efforts to mitigate climate change require ambitious long-term policies and commitments; however domestic public agendas are prone to modifications by changes in public administration after every election, thus creating the risk of ineffective implementation. The study of the socio-economical and political dynamics affecting the design and paths followed by climate policy fit the Horizon 2020 programme on Societal Challenges. The objective of the project “Evaluating the performance of local climate policies in Mexico (2009-2018)” (e-Lection) is to assess what are the determinants of the diffusion and successful implementation of climate policy at local jurisdictions. This research takes an in-depth look into climate governance and policy implementation in Mexico as an example of an emerging and democratic major economy actively involved in climate policy. It offers an excellent example for this purpose since it has stated publicly its climate policy goals since 2008. Mexico with its 32 federal entities and around 2470 municipalities offers a vast laboratory for studying the different factors that determine continued implementation of domestic climate policy over the last decade. The contrasting contexts in which implementation takes place in Mexico offer a comprehensive view that will provide valuable information to policy-makers locally and globally. The U.K has a long-standing tradition in the study and design of climate policy and associated economic instruments. Particularly the work made at the CCCEP has provided insightful research to policymakers around the world.

Keywords: climate policy,evaluation of policy implementation,long term action
Short Videos to Increase Learners uptake on Online Content (c2LEARN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-23
End date: 2019-10-22
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Introduction: Students use the Internet as the first point of contact when searching for learning materials to assist their studies. Such content may have a low evidence based background and may be misleading. One learning medium that is rated highly by students is the use of short educational videos. Objectives: The aim of this project is to create short video learning materials which are peer reviewed and accessible for dental students. Their creation and use will be an exemplar that may be used in dentistry and have a framework that allows translation into other disciplines. Material and Methods: A questionnaire will be distributed to European Dental Courses to verify their use of Information and Communication Technologies (ICT) with a focus on the use of short online videos. Following this short instructional videos will be created in several dental subjects and made available online following peer review. Their content will be evaluated qualitatively using face to face interviews with both students and their teachers. Following dissemination at dental education conferences, selected European partners will be invited to take part in evaluating the videos with a view to embedded them in their curriculum. The ER will learn new skills in qualitative research methodology and will develop a network of European Schools to evaluate new video production. Outcomes: This work will create a suite of dental videos that will be available to students across Europe. They will be peer reviewed and made available via the Internet to students. The project will develop a framework for future video creation by educators and will allow translation to other disciplines. The ER will learn a range of multidisciplinary skills including video creation, qualitative research methodology and have a suite of dental videos that will be made available to European Dental Schools. The host institution will benefit from how to embed ICT into dental education and with new partners.

Keywords: dentistry,teaching,teledentistry,education
Launching the GameInfluencer Marketing Platform to Connect Game Publishers With The Best Matching Influencers Who Create the Most Effective Let’s Plays (GameInfluencer)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Germany
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-01-01
End date: 2018-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The cost of acquiring users for games and apps increases monthly and by over 100% yearly. The 2015 user acquisition cost was around €3 There is a need for a quick and reliable way to identify the best influencer channels across the world. With influencers, we are referring to members of the gaming community that act as influencers. They create Let’s Plays or other material they post on their YouTube channel or social media to review games. Our Solution GameInfluencer connects game publishers with the best fitting influencers on YouTube, twitch and other platforms to drive app installs, boost app store rankings and create brand awareness! The single components of our platform exist in separation and in other industries and we are the first European company who a) integrate all the needed fragmented features, b) focus exclusively on the gaming industry and c) offer a unique market place. GameInfluencer is disruptive as it automates an otherwise manual process, thereby significantly lowering advertising cost. For big game publishers, they will have faster, cheaper and more predictable results (measured in views and/or installs) by using GameInfluencer. For smaller publishers, they have access to marketing campaigns they could otherwise not afford. In the medium-run, GameInfluencer can permanently disrupt the matchmaking for game marketing campaigns as influencers will move to marketplaces rather than taking orders manually. For Europe, the video gaming industry brings large economic benefits generating nearly $20 billion of the global $76 billion. To bring more revenues to Europe, European gaming companies/publishers need to be able to reach gamers on a global scale. GameInfluencer already allows running campaigns in 13+ languages. At GameInfluencer GmbH, we are on the way to becoming the leading international one-stop marketplace for booking, monitoring and paying influencer marketing campaigns.

Keywords: influencer marketing platform,let s play,online gaming,matching platform,video game advertising,marketplace for influencers and game publishers
A versatile ultrafast Click platform for antibody based radio diagnostics (RadioClick)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany,Germany
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-06-01
End date: 2019-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 87500.0
Participants: 3
Project status: CLOSED

Diagnosing cancer as early as possible is one of the most powerful strategies in modern medicine to improve human well-being. Antibodies (Abs) are excellent molecules that can be used to target specific tumors. As Abs require hours to days for accumulating on tumor surfaces, the use of Abs for nuclear imaging (such as PET imaging) is limited by the short half-lives of popular radioisotopes. Therefore, we plan to move the step of radiolabeling from the bench to the tumor itself. However, the entanglement of Abs with an artificial chemical probe is one of the most promising but at the same time one of the most technically challenging developmental areas in biotechnology. Our unique approach is based on the production of “hybrid-Abs”, which combine in only one “click” step the power of synthetic chemistry with the best of biology (“custom-biologics”). Our unique selling points are ultra-fast, exceptional bioorthogonal and specific labeling reactions in living organism as well as a both-sided modularity of the connection between Abs and chemical probe. By doing so, high contrast visualization of the cancer will become possible.

Keywords: noncanonical amino acid,labeling,radiomarker,site specific,click chemistry,tetrazine