Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development and Manufacturing of an All-Oxide Inter Turbine Duct for Aeroengines (AllOxITD)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Germany,Germany
Call: Development of an all-oxide Ceramic Matrix Composite (CMC) Engine Part (H2020-CS2-CFP01-2014-01, 2014)
Start date: 2015-12-01
End date: 2020-05-31
Duration (months): 54.0
Total project cost (EUR): 3489852.56
EU funding (EUR): 3072595.06
Participants: 3
Project status: CLOSED

The objective of the proposal is the development of an all-oxide Ceramic Matrix Composites (CMC) inter turbine duct for testing of the component in a demonstrator engine. The development steps include: - Designing the parts including the attachment to the metallic support structure - Defining design rules how to work with oxide CMCs for engine parts - Simulation of the parts behavior under engine loads - Assessment of the lifetime and reliability of the material in operation to translate the specimen behavior onto the component level - Optimizing the performance of the parts w.r.t. manufacturing parameters e.g. fiber orientation - Characterizing the material properties needed for the design process on specimen level. This includes the material development for example to improve the matrix system for prepreg technology - Manufacturing of the demonstrator parts - Develop a concept for fining qualification steps - Develop a concept for non-destructive testing - Validating simulation results with engine data resulting from engine tests For manufacturing oxide CMCs specimen and parts the following manufacturing techniques are included in the proposed project: - Winding - Prepreg technology (as automated as possible) - Braiding The path to final manufacture and validation will be documented and coordinated in close collaboration with the consortium partners and the topic manager. This proposal answers the CfP in “Work Package 4 – Advanced Geared Engine Configuration (HPC-LPT)” of the Engine Integrated Technology Demonstrators in Clean Sky 2. It utilizes the low specific weight of oxide CMCs to save weight and its inherent oxidation and temperature resistant nature to save cooling air. It therefore, contributes to the key objectives of the work package: improvement of efficiencies and innovative lightweight and temperature resistant materials.

Keywords: design,simulation,characterization and manufacturing of oxide cmcs parts,high temperature behaviour of oxide cmcs under demonstrator engine loads
INnovation CApacity of Mediterranean Enterpises (INCAME_2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Italy,Italy,Italy,Italy,Italy,Italy,Italy,Italy,Italy,Italy
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 419348.75
EU funding (EUR): 419348.75
Participants: 14
Project status: CLOSED

INCAME_2 The project aims to enhance SMEs’ competitiveness and innovation processes management and to improve the regional innovation environment, increasing the efficiency and the effectiveness of investments in research, development and innovation. The project partners will operate in the regions under the EEN BRIDGeconomies consortium: Abruzzo, Basilicata, Calabria, Campania, Molise, Puglia and Sicilia. The overall objective of the project is helping SMEs to adopt, implement and deploy an innovation management system. The project has two main specific objectives, structured in 2 Work Packages: WP1) SMEs beneficiaries of the SME Instrument (Key Account Manager) ; WP2) SMEs with innovation potential (EEN Innovation Expert) EIMC. To reach such specific objectives, during the period covered by the action, the project partnership intends to deliver seven / ten days service packages to a number of 110 SMEs, benefiting from SME Instrument grants and services for enhancing their innovation management capacities. Project partners intend to implement these actions since SMEs play a crucial role in reaching the objectives of the Europe 2020 Strategy and notably the Innovation Union. SMEs are key drivers of innovation serving as an important conduit for knowledge spill-overs. Tapping the full innovation potential of SMEs requires efficient support mechanisms. The focus needs to be oriented to impact on SMEs, looking at their internationalisation, their knowledge and R&D capabilities, competitiveness and growth.

Keywords: innovation management,enhancing smes capicities in southern italy
Modelling the therapeutic potential of NUAK1 suppression in colorectal cancer (NuSiCC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Colorectal cancer (CRC) kills up to 170,000 Europeans annually. Although survival rates have improved gradually, new treatment strategies are certainly needed. Hyper-activation of WNT/Beta-catenin signalling occurs in up 93% of CRC cases and MYC appears to be an obligate effector of Beta-Catenin in the gut, making MYC an attractive target for therapeutic intervention. MYC, however, is difficult to target directly, owing to its lack of enzymatic activity or obviously druggable structural features. An alternative strategy is to target the biological consequences of MYC deregulation. The Murphy lab recently showed that MYC overexpressing tumour cells in culture exhibit an ectopic dependency on a little-known kinase called ARK5/NUAK1: whereas cells lacking MYC overexpression are able to withstand NUAK1 depletion or inhibition, cells with overexpressed MYC are unable to maintain energetic homeostasis in the absence of NUAK1, deplete their ATP levels, and consequently lose viability. We have therefor taken a genetic approach to examine the requirement for NUAK1 during tumour development in a genetically engineered mouse model of sporadic Beta-Catenin-driven CRC. Our preliminary results show that NUAK1 is required for CR tumour initiation and, more importantly, that NUAK1 depletion shrinks pre-existing tumours, suggesting that NUAK1 is an excellent candidate target for treatment of CRC. Based on these exciting preliminary data, I now propose to thoroughly evaluate NUAK1 as a target for therapy in CRC and to use a combination of proteomic, phosphor-proteomic and metabolomics analysis to determine the mechanism by which NUAK1 suppression erodes tumour cell viability.

Keywords: nuak1,metabolism,colorectal cancer,spheroid culture,genetically engineered mouse models
WelcomINg and TraiNING of international high-level post-docs in Normandy (WINNINGNormandy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: France
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2020, 2020)
Start date: 2022-01-01
End date: 2026-12-31
Duration (months): 60.0
Total project cost (EUR): 5884800.0
EU funding (EUR): 2942400.0
Participants: 1
Project status: SIGNED

The WINNINGNormandy Fellowship Programme will foster the research excellence and innovation activities, and increase the international attractivity and influence of the Normandy Region in France by recruiting 40 two-year postdoctoral fellowships in two calls. The choice of the host institution and the research topic in the frame of the 6 areas of smart specialization is entirely left to the experienced researchers based on individual-driven international mobility. The consortium gathers the leading interdisciplinary higher education institutes, exceptional research organizations and large infrastructures in the region, as well as over 20 industrial partners (large groups, SMEs, start-ups) operating in the areas of specialization. They will strongly contribute to the implementation of the programme by hosting research fellows, providing secondments and/or specific training, intersectoral mentoring, networking and business opportunities. Several actors in human resources, project management, entrepreneurship and outreach complete the partnership to drive together the specifically tailored transferable skills training program, personalized career development, and encourage results exploitation and large diffusion. This ambitious educational and research programme will structure and implement the HRS4R principles for the postdoctoral level recruitment, working and living conditions, training and career management in the region, as well as contribute to sustaining and developing industrial activity in Normandy, making the green and energy transition a success and improving the well-being of citizens and the resilience of the territory.

Keywords: post doctoral research fellowships,normandy region,international,intersectoral,interdisciplinary training,smart specialization,transferable skills
Understanding and controlling complex systems (UCoCoS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium,France,Netherlands
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EJD) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-04-01
End date: 2020-03-31
Duration (months): 48.0
Total project cost (EUR): 1537619.76
EU funding (EUR): 1537619.76
Participants: 3
Project status: CLOSED

Europe faces major challenges in science, society and industry, induced by the complexity of our hyper-connected world. Examples are the climate change, infectious diseases, artificial interconnected systems whose dynamics are beyond our understanding such as the internet, the global banking system and the power grid. A demand of performance emerges at an unprecedented scale: collaborative sensors and robots so to ensure competitiveness of our European production industry, better management of our traffic flows, designing (de)synchronization mechanisms applicable in neuroscience, are examples illustrating the necessity to understand and control the dynamics of complex networks. However, this requires a fundamentally new kind of complexity science. The traditional way of reducing a system to its components fails when the global dynamics are determined mainly by the interactions. Moreover, an interdisciplinary approach is necessary as revealing common principles is key in getting grip on the complexity. The objectives of UCoCoS are to create a control-oriented framework for complex systems, and to define a common language, common methods, tools and software for the complexity scientist. Moreover, as the first training network on the theme, UCoCoS aims at i) creating a closely connected new generation of leading European scientists, capable of designing network structures and policies to affect the networks, and ii) initiating long-term partnerships and collaboration mechanisms leading to sustainable doctoral training. The UCoCoS approach builds on recent developments in three domains (control, computer science, mechanical engineering) and stems from the identification of a unique combination of expertise within the consortium. Every ESR performs a cutting-edge project, strongly relying on the complementary expertise of the three academic beneficiaries and benefiting from training by non-academic partners from three different sectors.

Keywords: complex systems,synchronization,delay,large scale algorithms,nonlinear dynamics
Strategies to tackle the Quest for Hadronization (SQuHadron)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2022-08-31
Duration (months): 36.0
Total project cost (EUR): 262269.0
EU funding (EUR): 262269.0
Participants: 2
Project status: CLOSED

The internal structure of hadrons in terms of their elementary constituents (partons) and the transformation of a parton into hadrons (hadronization) are two sides of the same coin, namely the nonperturbative core of Quantum Chromodynamics (QCD), the field theory describing the strong force. This research proposal “Strategies to tackle the Quest for Hadronization” (SQuHadron) pioneers new ways to extend our understanding of hadronization. Factorization theorems allow us to describe hadronization in terms of fragmentation functions (FFs), which reflect the probability that a quark transforms into one or more hadrons. A deeper understanding of hadronization requires the extension of the standard one-dimensional unpolarized FFs to multi-dimensional objects, including polarization and (non)perturbative contributions: the project will make significant steps forward in this direction. Standard fragmentation functions are already used also as tools to access the internal structure of the hadrons. Their generalization will turn them into much more sophisticated “probes”, whose phenomenological potential is very timely in the light of the current and future experimental efforts. The benchmark reaction addressed in the proposal is electron-positron annihilation. According to the final states, different aspects of hadronization will be studied. The goals of SQuHadron are: complete the formalism for analyzing 3D unpolarized FFs and extract them from data; define a framework to study chiral-odd FFs for single-hadron, di-hadron and jet production. The experienced researcher is a phenomenologist of hadronization and hadron structure. To broaden his skills and enhance his career prospects, he planned a training in perturbative QCD, which will lead to the fulfillment of the key goals of this proposal. Benefiting from the stimulating environments in Jefferson Lab and Pavia University, these efforts will be of utmost importance to become a mature and independent scientist.

Keywords: hadronization,fragmentation functions,hadron structure,parton distribution functions,factorization,perturbation theory,phenomenological analyses
Foundations of Animal Sentience (ASENT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom,United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2025-06-30
Duration (months): 66.0
Total project cost (EUR): 1499864.0
EU funding (EUR): 1469188.0
Participants: 3
Project status: SIGNED

The goal of ASENT is to construct solid conceptual and methodological foundations for the science of animal sentience. The term sentience refers to an animal’s subjective experience of the world and of its own body. In recent years, an interdisciplinary community of animal sentience researchers, drawn from neuroscience, comparative psychology, evolutionary biology, animal welfare science and philosophy, has begun to emerge. However, the field is characterized by foundational controversy over the nature of sentience and the criteria for its attribution, leading to heated debate over the presence or absence of sentience in fish and in invertebrates such as cephalopods and arthropods. ASENT aims to find ways to resolve these debates, enabling researchers to move beyond the impasses that result from deep foundational disagreement. What is needed is a conceptual framework for thinking about sentience as an evolved phenomenon that varies along several dimensions, a deeper understanding of how these dimensions of sentience relate to measurable aspects of animal behaviour and the nervous system, and a richer picture of the links between sentience, welfare and the ethical status of animals. ASENT will answer this need by providing: 1. An account of the basic functional capacities involved in sentience, and an evaluation of which capacities justify us in regarding an animal as a sentience candidate. 2. An overarching conceptual framework for understanding the dimensions along which sentience varies across the animal kingdom, based on distinguishing multiple structural properties of sentience; 3. A scheme of proposed experimental tests for constructing a species’ most likely sentience profile with reference to these dimensions, implemented with scientific collaborators using bees as a test case. 4. An assessment of which dimensions of sentience are most relevant to animal welfare and to the ethical status of animals.

Keywords: animal sentience,animal cognition,animal consciousness,animal minds,animal welfare
A pilot line for the next generation of smart catheters and implants (POSITION-II)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Spain,Spain,Ireland,Italy,Germany,Germany,Germany,Spain,Ireland,Ireland,Germany,Germany,Spain,Italy,Germany,Germany,Germany,Germany,Spain,Finland,Hungary,Switzerland,Sweden,Belgium,Switzerland,France,France,France,France,Netherlands,Netherlands,Netherlands,Portugal,Portugal
Call: IA (H2020-ECSEL-2017-1-IA-two-stage, 2017)
Start date: 2018-06-01
End date: 2021-09-30
Duration (months): 40.0
Total project cost (EUR): 40947272.06
EU funding (EUR): 10418998.22
Participants: 49
Project status: CLOSED

The objective of POSITION-II is to bring innovation in the development and production of smart catheters by the introduction of open technology platforms for miniaturization, AD conversion at the tip, ultra-sound MEMS devices and encapsulation. Open technology platforms will generate the production volume that will enable sustainable innovation. The availability of open technology platforms will result in new instruments that have a better performance, new sensing and imaging capabilities, while the scale of volume will result in lower manufacturing costs. The production of the “brains” of these smart catheters will take place in Europe, with many European partners contributing essential technologies. The POSITION-II project will consolidate Europe’s premier position as manufacturer of cath lab infrastructure since these new smart catheters will be seamlessly integrated in the cath lab hardware and software platforms. By combining the different sensing and imaging data a more intuitive cath lab experience will be achieved. Looking forward, POSITION-II prepares the European electronics industry for the next revolution in healthcare, bioelectronics implants. Bioelectronics implants are expected to replace a considerable fraction of traditional medicine by direct stimulation of nerves. The miniaturization and soft encapsulation platforms developed in POSITION-II will be the ideal technology frame work for the manufacturing of these bioelectronics implants. The technology platforms developed in POSITION-II are demonstrated by five challenging product demonstrators covering FRR, IVUS, ICE, EP and cell therapy as well as a bioelectronics implant to treat cluster headache.

Keywords: smart catheters,cath lab,open platforms,ivus,implantables
Photonic Integrated Circuits Assembly and Packaging Pilot Line (PIXAPP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Germany,Italy,Italy,Germany,Germany,Germany,Ireland,Ireland,Switzerland,Belgium,Finland,France,France,Czechia,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Photonics KET 2016 (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2021-09-30
Duration (months): 57.0
Total project cost (EUR): 15690921.43
EU funding (EUR): 13407812.76
Participants: 25
Project status: CLOSED

PIXAPP will establish the world’s first open access Photonic Integrated Circuit (PIC) assembly & packaging Pilot Line. It combines a highly-interdisciplinary team of Europe’s leading industrial & research organisations. PIXAPP provides Europe’s SMEs with a unique one-stop-shop, enabling them to exploit the breakthrough advantages of PIC technologies. PIXAPP bridges the ‘valley of death’, providing SMEs with an easy access route to take R&D results from lab to market, giving them a competitive advantage over global competition. Target markets include communications, healthcare & security, which are of great socio-economic importance to Europe. PIXAPP’s manufacturing capabilities can support over 120 users per year, across all stages of manufacturing, from prototyping to medium scale manufacture. PIXAPP bridges missing gaps in the value chain, from assembly & packaging, through to equipment optimisation, test and application demonstration. To achieve these ambitious objectives, PIXAPP will; 1) Combine a group of Europe’s leading industrial & research organisations in an advanced PIC assembly & packaging Pilot Line facility.2) Develop an innovative Pilot Line operational model that coordinates activities between consortium partners & supports easy user access through a single entry point. 3) Establish packaging standards that provide cost-efficient assembly & packaging solutions, enabling transfer to full-scale industrial manufacture. 4) Create the highly-skilled workforce required to manage & operate these industrial manufacturing facilities.5) Develop a business plan to ensure Pilot Line sustainability & a route to industrial manufacturing. PIXAPP will deliver significant impacts to a wide stakeholder group, highlighting how industrial & research sectors can collaborate to address emerging socio-economic challenges.

Keywords: assembly,packaging,sensors,medical technology,communications,security,integration,supply chain,standards,training,smes,test and reliability