Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Genomics of social structure and its implications for conservation (GINS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2025-03-31
Duration (months): 30.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: CLOSED

The habitats of most vertebrates are disappearing at an increasing rate with major consequences for their survival and that of humans. Increase in disease emergence and levels of poverty are two of its many impacts, which pose a threat to a sustainable economy worldwide. Monitoring and managing species is essential to restore a sustainable use of resources. Genomics approaches provide a framework to quantify the health status of species using genetic diversity, inbreeding and demographic history. However, such approaches have been widely ignoring a defining aspect of many threatened species – social groups, the fundamental units in which many species are organised, live and reproduce. Through this MSCA-IF, I will develop a new framework using identity-by-descent genomic information to infer socioecological parameters, e.g. group sizes and migration rates - essential for the survival of species. Taking advantage of new readily available samples of mouse lemurs, this action will provide direct input to Madagascar, serving as a model to evaluate recent past anthropogenic actions and, more vitally, preview the impact of ongioing changes on the socioecology of species, under alternative land-use scenarios. This will be a general framework to study the social structure of many other species faced with similar environmental challenges across the globe. The rising public awareness of ecological changes makes it an ideal time to share knowledge on biodiversity, and I will strongly invest in outreach activities. This action provides a unique opportunity for me to learn an essential set of skills on high level statistical genomic methods and non-model organisms’ genomics analysis, coupled with cultivating an extensive new network of expert collaborations. Through this action, I believe I will contribute to conservation genomics and specifically to lemur conservation while gaining invaluable assets for my career development as an independent researcher.

Keywords: sociality,mating systems,inbreeding,genomics,endangered species,lemurs,identity by descent tracts ibd,runs of homozygosity roh
Welcome to the age of frictionless mobility. (Magrail)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Poland
Call: EIC Accelerator Challenge: Technologies for ‘Fit for 55’ (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-12-01
End date: 2025-10-31
Duration (months): 35.0
Total project cost (EUR): 9812301.18
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

MagRail will bring frictionless mobility (levitating trains) to conventional tracks. Our system upgrades a conventional railway line with MagRail infrastructure components (linear motor and levitation beams), supplemented by signaling and traffic control system, and vehicle components (e.g. bogie). As a result, MagRail allows for interoperability of conventional and magnetic trains on the same track, which makes the system unique. Retrofitting conventional railway lines’ (speeds up to 160 kph) or high-speed railway lines’ (330 kph) infrastructure into MagRail will allow to substantially increase the speeds to up to 330 and 550 kph respectively, which will bring massive savings in time and money. MagRail will radically increase the capacity and flexibility of railway lines, bringing more goods and passengers to railways, supporting a real modal shift from road, air, and sea to rail, making zero-emissions goals and sustainability targets more achievable.

Keywords: design innovation,multimodality
PhysIcs departmeNts' CuLture, strUcture and genDer inEquality (INCLUDE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-04-03
End date: 2025-10-02
Duration (months): 30.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 2
Project status: SIGNED

The discipline of physics has been grappling with the issue of gender imbalance for decades. The underrepresentation of women in physics profoundly affects the growth and future of the field by contributing to a loss of potential talent and deprives industry of the intellectual contribution of women with a physics background. Those women physicists who enter the workplace remain dramatically outnumbered especially within senior management. The persistence of this gender imbalance suggests that it is due to a combination of many factors, interacting dynamically in complex ways, necessitating holistic and integral solutions. Interventions, so far, have been generic and have focussed overwhelmingly on the micro-level (individual learner, teacher, employer, and family). The thesis of this project is that measures taken to increase representation will be effective only when they include addressing underlying hidden structures of the physics culture that contribute to the gender inequality. In order to unpack the factors that shape how physics engages with women, this work employs semi-structured, artefact-based ethnographic interviews of third-level students (physics and non-physics) and physics academic staff drawn from two institutions in culturally different environments. An interdisciplinary framework will be established to articulate structures, representations, policies and practices that contribute to the gender inequality in third-level physics education. The processes involved will identify the tangible structural changes that can be implemented. The outcomes of this work will empower physics departments internationally to move beyond generic strategies and to implement tailored action plans to address gender imbalance by on-going, collaborative self-reflexivity. These processes and outcomes are transferable to other underrepresented populations in STEM fields and careers, and hence carry academic and economic implications.

Keywords: physics,women,gender,imbalance,inequality,stem,diversity,minority,underrepresented
Neuromorphic Flexible Electro/chemical Interface for in-Memory Bio-Sensing and Computing. (NEFELI)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Belgium,Italy
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: SIGNED

Efficient assessment of multiple bio/chemical and electrophysiology biomarkers directly at the area of interest is an indisputable asset in the individualized healthcare. However, current implantable systems and bioelectronic technologies still face limitations in ultra-sensitive bio-sensing, address the electrical and chemical aspects fragmentally, and depend on complex setups and computationally heavy off-line processing. Conventional von Neumann architectures face limitations in efficiently handling the increasing sensor output data that can be mainly attributed to the physical separation between sensing, memory, and computing units. Here the overall objective is to conceptualize a first-of-its-kind, miniaturized, and self-contained biosensing technology employing neuromorphic devices functioning as on-node sensors and processors (in-memory (bio)sensing and computing), in soft, flexible and bio-compatible materials and format. I will demonstrate this technology showcasing, in an in vivo animal model, a proof-of-concept implantable bio-interface that intelligently interrogates and classifies neurodegenerative disease-related bio/chemical and electrical biomarkers, coupled with active elements enabling precise adjustment of stimulation control parameters based on analog inputs. This technology holds great potential to advance our understanding and treatments of pathologies through multiplex electrical and chemical monitoring reducing the demands for power-intensive analog-to-digital conversion and computational processing. Furthermore, it paves the way for tailored interventions, laying the foundation for next-generation biomedical modulation systems.
Cross-sectoral Framework for Socio-Economic Resilience to Climate Change and Extreme Events in Europe (CROSSEU)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: Romania,Czechia,United Kingdom,Switzerland,Italy,Germany,France,Austria,Denmark
Call: Socio-economic risks of climate change in Europe (HORIZON-CL5-2022-D1-01-two-stage, 2022)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 3444625.0
EU funding (EUR): 3444624.0
Participants: 15
Project status: SIGNED

The project CROSSEU aims to respond to the increasing societal needs to reduce climate-damaging actions, adapt to the expected consequences and increase socio-economic resilience. The project aims is to deliver a climate-sensitive framework, including a ready-to-use decision support system platform and technical recommendations, to inform investment decisions, cost-effective adaptation and mitigation options and policy response to climate change. The project will contribute to advancing the understanding of the socio-economic risks and response options associated with climate change impact in Europe in different timeframes, including the post-COVID19 societal-environmental transformation, and derive practical recommendations for political and societal action. The solutions proposed are based on an extensive assessment of the socio-economic risks of climate change in a cross-sectoral hierarchical approach, based on storylines addressing key categories of climate hazards in different socio-economic sectors and climate change-sensitive areas across countries and European regions. The project will offer a ready-to-use solution that integrates complex information from available climate risk data sets and non-climatic sectoral data collected during the project implementation and derived through modelling based on demand-driven climate-socio-economic pathways. CROSSEU is designed to bridge the science-based information about the economic impacts of climate change and the unique contributions of the project will be (i) the quantification of costs of existent and emergent socio-economic risks and opportunities at NUTS3 level, (ii) an improved representation of adaptation within biogeophysical climate change risk and (iii) a better consideration of modelling uncertainties by identifying their nature, assessing their characteristics in a systematic way to determine a better informed and robust decision-making.

Keywords: climate change,socio economic impacts and risks,climate policy,climate resilience,interdisciplinarity,climate adaptation and mitigation,decision support,cross sectoral climate change impact
Proving causality of liquid-liquid phase separation for the acquisition of nuclear-like functions by Giant Viruses Viral Factories (ViDaMa)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1499196.0
EU funding (EUR): 1499196.0
Participants: 1
Project status: SIGNED

Giant Viruses (GVs) encode thousands of ORFan genes but their study has been nearly impossible due to the lack of genetic tools for reverse genetics. The aims of ViDaMa and the tools I designed will shed light into this Viral protein Dark Matter. Particularly, I will study how new genes from Mimivirus were engineered during evolution to acquire nuclear-like function for their Viral Factories (VFs). VFs physically separate viral DNA replication and transcription from translation and likely segregate DNA into active and silent. How these functions are accomplished remains elusive. I will demonstrate causality of liquid-liquid phase separation (LLPS) for the acquisition of nuclear-like functions of the Viral Factories (VFs) of Mimivirus. To do so, I will: 1) Generate genome-wide loss-of-function screens for the identification of gene function and proteome-wide localization of virtually all Mimivirus and its host Acanthamoeba proteins. 2) Combine biochemistry and cell biology to dissect the nature, functions and components of the VFs of Mimivirus. 3) Strip down VFs to their minimal components in order to utilize them to improve production efficiency and purity of mRNA during in vitro transcription. ViDaMA will empower the GVs scientific community with genome-wide and proteome-wide data of gene function and protein localization. It will transform the field from mostly descriptive to allow the dissection of the molecular mechanisms behind viral phenotypes. ViDaMa will also address the molecular mechanisms that allow the VFs to acquire nuclear-like functions, directly tackling the viral eukaryogenesis theory. The new classification of VFs as membrane-less organelles and the study of the molecular mechanism behind their biogenesis and functions will shed light into general mechanism of LLPS. The generation of in vitro VFs promises an optimization of in vitro transcription systems with tremendous impact on mRNA therapeutics at the development and production level.

Keywords: giant virus,mimivirus,liquid liquid phase separation,in vitro transcription,genome wide screening,orfan,protein dark matter
Biobased, fully biodegradable, microplastic-free nanocarriers selectively releasing encapsulated actives for sustainable agriculture (BIOFARM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-02
End date: 2026-09-01
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

Responding to the growing population in times of climate change, new techniques are essential to transform agriculture into a sustainable but even more productive system. Agrochemical delivery based on micro- and nanocarriers emerged as an efficient tool to decrease pesticide need against various plant diseases. However, these formulations also need non-degradable additives, such as spreading agents or adhesives. While studies underline that the widely used polymeric carriers in agrochemical delivery can release microplastics, research on additive-free or fully biodegradable formulations is very scarce. The aim of BIOFARM is to understand and develop new nanocarriers for agriculture that omit all non-degradable ingredients and release their payload only on-demand. Fully biobased and biodegradable nanocarriers will be designed as efficient vehicles to deliver and selectively release actives, without the danger of microplastics-formation. More importantly, I will design the nanocarriers surface in such a way to optimize spreading on the leaves and achieve effective adhesion to prevent other non-degradable additives. A general approach for encapsulated plant protection products in designed nanocarriers will be devised for foliar spraying. Without adding environmentally problematic additives, the enhanced adhesion of the proposed nanocarriers will be tailored through bio-polymer modification and green formulation design. The designed nanocarriers will not only be examined by various plant pathogens through vitro tests, but also will be tested on plant leaves on the field. A set of analytical techniques will be used to investigate various characteristics of the prepared nanocarriers, such as the adhesion on the leaves, biodegradation and efficiency. The proposed fully biodegradable nanocarriers represent a general concept and green formulation to replace non-degradable micro- and nanocarriers in the important foliar-spraying market of modern plant protection.

Keywords: biodegradable,biopolymer,nanocarrier,encapsulation,agrochemical delivery
Volcan Activity monItoring by light cycled dynamic opeRation of metal oxide gas sensors (VolcanAI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2026-04-30
Duration (months): 30.0
Total project cost (EUR): 206641.2
EU funding (EUR): 206641.2
Participants: 2
Project status: CLOSED

There exists a direct relation between gas emissions and earth’s dynamics and climate: the impact of anthropogenic emissions and volcanic eruptions on the climate are well known and from the opposite, the effect of the climate on the volcano activity remains mainly unexplored. To develop climate-volcano models and improve eruption predictive models, a comprehensive study of volcanic emissions is necessary. Reference measuring systems, which are used by the National civil protection agencies and which one can find in the market, are highly sensitive, complex, bulky, expensive and have a high power-consumption. Consequently, they can only be installed in few specific locations. For an accurate spatial monitor of these complex gas mixture emissions, however, a large number of sensing systems need to be deployed and connected, providing the required ubiquity, something which is possible nowadays thanks to Internet of Things (IoT). Usually, these systems do not need to meet the sensitivity level of the reference instruments. The present project addresses the development, fabrication, and testing of gas sensors for their implementation in IoT systems that will be deployed in the close vicinity of volcanoes. These devices will be made from advanced and harsh-resistant metal oxide (MOX) nanomaterials and will be based on an unexplored dynamic mode (DM) of operation. In opposition to the so-far reported DM systems, based on temperature pulsing, here we propose to use light cycled operation (LCO), in which a single low-power pulsed light-emitting diode photoactivates the MOX, which provides the different gas response patterns required for the correct gas discrimination. This constitutes an electronic-nose and dramatically reduces the number of sensors and power consumption required for gas discrimination. The developed devices will be tested towards gases typically emitted by volcanoes and will be benchmarked against reference measuring systems.

Keywords: gas sensor,nanomaterials,dynamic mode of operation,volcanic eruptions,electronic nose,internet of things,climate
Characterizing and harnessing tumor-reactive T cells in the brain (CENTRIC-BRAIN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 2499861.0
EU funding (EUR): 2499861.0
Participants: 2
Project status: SIGNED

Personalized tumor immunotherapy - vaccines and T cell therapies - requires the selection of few immunogenic epitopes recognized by tumor-reactive T cell receptors (TCRs) from thousands of potential tumor antigens in each tumor. This selection is a huge challenge, particularly in brain tumors, where access to tumor tissue is limited and tumor-infiltrating T cells (TILs) are sparse. CENTRIC-BRAIN will reverse this epitope-centric approach by directly harnessing tumor-reactive orphan TCRs from TILs for personalized brain tumor immunotherapy. Using human brain tumor tissue we have developed and experimentally validated predicTCR, a novel approach using machine learning and explainable AI to derive a classifier that predicts tumor-reactivity of such orphan TCRs based on the expression of signature genes with > 90% accuracy across multiple tumour entities. CENTRIC-BRAIN will employ predicTCR to develop a personalized adoptive cell therapy using transgenic T cells with tumor-specific TCRs and improved function. CENTRIC-BRAIN hypothesizes that the signature genes underlying predicTCR determine the phenotypic and functional properties of tumor-reactive T cells and that predicted tumor-reactive orphan TCRs can be employed for adoptive therapy with personalized TCR-transgenic T cells. Aim 1 will refine predicTCR by characterizing the transcriptional programs and spatial distribution of tumor-reactive T cells in human brain tumor samples. Aim 2 will define the functional relevance of transcriptional programs for tumor-reactive T cells in syngeneic humanized and patient-derived xenograft brain tumor models. Aim 3 will validate the predicted tumor-reactive orphan TCRs by adoptive transfer of T cells genetically engineered to express predicted tumor-reactive TCRs. CENTRIC-BRAIN will thus revolutionize precise and efficient implementation of personalized adoptive cell therapy for brain tumors using T cells expressing tumor-reactive patient-derived orphan TCRs.