Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
IMplementation Plan for Actions on CCUS Technologies in the SET Plan (IMPACTS9)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Coordination and support actions
Countries involved: Belgium,Belgium,Norway,Belgium,United Kingdom,United Kingdom
Call: Support to the realisation of the Implementation Plans of the SET Plan (H2020-LC-SC3-2018-Joint-Actions-2, 2018)
Start date: 2019-05-01
End date: 2022-04-30
Duration (months): 36.0
Total project cost (EUR): 1100298.75
EU funding (EUR): 1100298.75
Participants: 7
Project status: CLOSED

The overarching objective of Project IMplementation Plan for Actions on CCUS Technologies in the SET Plan - IMPACTS9 - is to support the realisation of the SET Plan Implementation Plan on CCS and CCU (hereafter referred to as CCUS). Multiple studies have highlighted that CCUS technologies are expected to play a critical role in the decarbonisation of the European energy and industrial sectors. However, to date CCUS has not been developed in Europe to the extent needed if the EU is to deliver on its climate goals and support the transition to a low carbon economy. It is important that there is a renewed focus on the development of CCUS projects in Europe. In 2016 the European Commission, SET-Plan countries, and industry, outlined a Declaration of Intent for CCUS containing 10 targets for 2020, the combination of which will, if delivered, represent a material step towards commercialisation of CCUS technologies in Europe. A SET-Plan Temporary Working Group 9 was established to develop an Implementation Plan which set out eight Research & Innovation (R&I) Activities which can help to realise the 2020 CCUS targets. The Implementation Plan was approved by the European Commission in September 2017. IMPACTS9 will support delivery of the R&I activities outlined in the Implementation Plan for CCUS through the provision of coordination and support to the key public and private stakeholders that are well placed to progress the SET-Plan Implementation Plan actions in the near term. IMPACTS9 will establish sub-groups to support delivery of the R&I activities and progress CCUS. Each work package is designed to support the work of these sub-groups in delivering the R&I activities. The consortium is composed of organisations highly representative of these stakeholders and will engage with them for their active contribution in the implementation of the SET Plan.

Keywords: ccus,carbon capture,storage utilisation,climate,energy,industry
Immediate and long-term health risks of excessive screen-based media use (SCREENS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2023-01-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Excessive screen-based media use in young people is a clear emerging public health concern which commands serious attention and research to keep pace with the fast and profound changes in technology of screen media and how it is used. The proposed research project’s overarching objective is to investigate the immediate and long-term effects of screen-based media use on a number of important health outcomes in young people. In work package (WP) 1 and WP2 we will investigate the short-term effect of limiting screen use and timing of limiting use on circadian rhythm, sleep, physical activity patterns, and mental stress in 7-year old children and among adolescents/young adults. The WP3 of the proposed project will develop and validate a parent- and self-reported questionnaire to assess time spent (and timing of use) on different forms- and content of today’s screen media among young people and adults. We will introduce these instruments in a number of large-scale population-based cohort-studies. One of the studies will include a large birth-cohort study, which is the basis for the WP4 sub-study. The 7- and 9-year wave of the birth cohort study will provide an ideal context to investigate the long-term influence of exposure to screen-based media on physical fitness, adiposity, glucose metabolism, and mental health in children. The project will integrate multidisciplinary research into the most thorough investigation to date of the plausible short- and long-term effects of screen-based media. Through rigorously conducted randomized crossover experiments and prospective observations in a birth cohort the present project proposal will leverage methodological development of screen use assessment and new technology advancements to assess physical activity patterns, circadian rhythm, sleep, and mental stress in randomly selected young people. The project will break new ground in our understanding of the extent that today’s habitual screen use affects health of young people.
Platelets: at the nexus of brain aneurysm (PANDORA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-12-01
End date: 2018-11-30
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Intracranial aneurysms (IA) with and without subarachnoid haemorrhage (SAH) linger as a potentially devastating clinical problem. Current therapeutic options are limited to invasive therapies, namely microsurgical clipping and endovascular treatment, both of which carry a significant risk of procedural morbidity. Increasing evidence points to inflammation as one of the leading factors in the pathogenesis of IA. Intrasaccular thrombus formation is a common feature of intracranial aneurysm occurring in 25% of unruptured and 70% of ruptured IA. In addition to forming clots, activated platelets support leukocyte recruitment. This cross-talk is a common feature in thrombo-inflammatory vascular disease. Despite these deleterious aspects of platelets, they also prevent local hemorrhage in inflammatory situations independently of their ability to form a platelet plug. The pathophysiological evolution of IA events seems driven by complex cellular interactions between different cell types including platelets, leukocytes and vascular cells (endothelial cells, smooth muscle cells). We hypothesize that the role of platelet roles may evolve throughout the development of IA: initially playing a protective role of in the maintenance of the blood brain barrier in response to inflammation and contributing later to intrasaccular thrombus formation. Therefore, altered platelet function may result in a loss of protection against vascular inflammatory insults. The main objective of this proposal is to better understand and decipher platelet mechanisms during IA formation and rupture. In this current application, we will (i) define platelet activation mechanisms in the development of IA and the impact on the blood-brain barrier integrity, (ii) test efficient anti-platelet therapies in the development and rupture of IA, (iii) define an efficient therapeutic window to intervene on platelet activation (prevention or intervention).

Keywords: platelets,leukocytes,vessels
‘Reciprocal Encounters’ - Young Adults Leaving Care (ReProCounters)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The objective of this proposal, ‘Reciprocal Encounters – Young Adults Leaving Care’, is not only to produce preventive, client-based social work guidelines regarding how to search for the best ways to support the well-being of young adults with substitute care experiences and the process of their deinstitutionalisation or leaving substitute care, but it will also use a complementary participatory research methodology to explore the research questions, undertaking research with young adults, not just on them, thus delivering user-driven results. The study searches for solutions to improve social work policy–practice related to young adults’ participation, increase young adults’ awareness of the options to participate in welfare policy and social work policy–practice making and how to strengthen the young adults’ capabilities to act in their communities and help them obtain new skills that will be useful, for instance, in their working lives. The objective of the proposal will be achieved through theory-building and methodological improvements concerning participatory research with young adults. The study is structured into two case studies with young adults who have left family or institutional care – one in the United Kingdom and one in Finland – representing different welfare states in Europe and their child welfare services. The data set for Finland already exists (n = 25), and a similar data set will be gathered for the UK (n = 25) following the same methods of participatory research as those used in Finland. For the researcher, this project offers an invaluable opportunity to expand her knowledge of theory-building regarding reciprocal participation and well-being, and to gain skills in public engagement and research communication. The project also gives her unique opportunities to grow her international collaboration network and new links with related European and global networks through complementary academic and non-academic secondment/placements.

Keywords: reciprocity,participation,well being,participatory research,young adult,leaving care,substitute care,social work,child welfare,social care,independence,interdependence,deinstitutionalisation
Spatio-Temporal Regulation of Inflammation and Tissue Regeneration: Studying the immune system - tissue - microbiota communication to develop targeted therapies for immune-mediated diseases and cancer (REpAIR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-10-01
End date: 2026-03-31
Duration (months): 66.0
Total project cost (EUR): 1999687.0
EU funding (EUR): 1356125.0
Participants: 2
Project status: SIGNED

Inflammation is fundamental to promote tissue regeneration upon injury, and in turn, the resolution of the immune response. Physiological tissue regeneration depends on fine-tuned interaction between the immune system, the tissue, and the microbiota. However, the complex communication between these three components and the molecules that mediate it are unclear. Understanding this is fundamental to prevent immune-mediated diseases and even cancer. This is particularly important at mucosal surfaces, where continued regeneration occurs. Therefore, we hypothesize that inflammatory bowel disease (IBD) and colorectal cancer (CRC) are a consequence of a miscommunication between these components. Interleukin-22 (IL-22) is one key orchestrator of this communication: It is produced by immune cells and by acting on intestinal epithelial cells, it modulates the composition of the microbiota and promotes tissue regeneration. However, IL-22 can also promote both chronic inflammation and cancer. Exactly what regulates these paradoxical effects remains unclear. Of note, there is an endogenous inhibitor of IL-22, namely IL-22 binding protein (IL-22BP), which blocks IL-22 activity. We hypothesize that a misguided spatio-temporal regulation of the IL-22 – IL-22BP axis is the cause of pathogenic effects of IL-22. In particular, we will analyse: (i) the location, and the functional and molecular heterogeneity; (ii) the origin and fate of IL-22 and IL-22BP producing immune cells; and (iii) the role of the microbiota in regulating them. To this end, we will use new transgenic and gnotobiotic mouse models, single cell RNA sequencing and human samples. In short, by studying the IL-22 - IL-22BP axis, we will understand how the complex interactions between the immune system, the tissue, and the microbiota lead to either physiological or pathological tissue regeneration. This will provide the basis for therapies controlling inflammation and tissue regeneration in a spatio-temporal manner.

Keywords: inflammatory bowel disease,colorectal cancer,t cells,microbiota,cytokines,tissue regeneration
Temporalities of Andean Heritage Landscapes (TAHL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Australia,Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2022-05-01
End date: 2024-04-30
Duration (months): 24.0
Total project cost (EUR): 178202.88
EU funding (EUR): 178202.88
Participants: 2
Project status: SIGNED

How can project/site managers consider local categories and ideas of time when conceptualizing, managing, and protecting indigenous archaeological sites in the Andes? At a time when politicians and scholars give increasing importance to local perspectives, few models exist for addressing the conflicting temporalities of Andean indigenous heritage. My project engages this problem by undertaking an ethnographic inquiry into the Quechua category of muyuy with reference to how time is understood through the material world and use of space in the community of Chinchero, in the Cuzco region of Peru. Muyuy is an Andean long-standing, key organising and dynamic principle of socio-political and ritual life that projects social relationships onto the landscape in different forms. Semantically, it is a concept charged with the temporalities of rotation, alternation, and circulation. As customary law and action, muyuy organises communal agricultural work and production by periodically rotating the plots allocated to families for their sustenance, ensuring rights to land. While muyuy has received some previous attention in the literature, my work will examine this idea in the most depth to date. My previous doctoral research on the topic has already laid the foundations for a more thorough and productive study. An emphasis on muyuy and other temporal categories is (relatively) new. By focusing on native temporalities my project intersects current anthropological debates on indigenous landscapes, as well as current indigenous efforts worldwide to regain control over their archaeological heritage.

Keywords: andes,indigenous heritage landscapes,temporalities
The mechanism of acquired thermotolerance in potato (ACQUIRE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

For many commercial potato cultivars, tuber yield is optimal at average day time temperatures in the range of 14-22˚C. Further rises in ambient temperature can reduce or completely inhibit potato tuber production, with damaging consequences for both producer and consumer. Despite centuries of potato breeding, high temperature tolerance has not been significantly improved. Targeted breeding approaches are hampered by a lack of knowledge on the molecular mechanisms of how plants perceive and translate high temperature into relevant acclimation responses. Although in recent research we have identified genotypes that can yield well under elevated temperatures, we have not yet dissected which responses to elevated temperature are the most critical for yield. Thus the objectives of ACQUIRE are: to develop a robust screen to assay for acquired thermotolerance in potato; to test potato genotypes and transgenic lines for variation in the acquired thermotolerance response; to determine transcriptional and metabolite profiles associated with acquired thermotolerance; to introgress beneficial alleles of a potato heat tolerance gene (StHot1) to develop Nearly Isogenic Lines with improved acquired thermotolerance characteristics; to assess the impact of acquired thermotolerance on tuber yield in a range of genotypes. The project will serve a training vehicle for an experienced researcher to enhance her portfolio of research skills and so increase their ability to innovate in this important area of food security. The experienced worker will add an extra dimension to current research activities in the host organisation by sharing her current expertise. The outcomes will be of commercial and societal interest and a raft of measures will be taken to ensure thorough dissemination of the project activities. The project will leave the experienced worker well-qualified to achieve professional maturity and will have a legacy of collaboration and new research avenues to be explored.

Keywords: plant physiology,crop genetics,plant breeding
Coding for Security and DNA Storage (inCREASE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-03-01
End date: 2024-02-29
Duration (months): 60.0
Total project cost (EUR): 1471750.0
EU funding (EUR): 1471750.0
Participants: 1
Project status: SIGNED

Communication and data storage systems are indispensable parts of our every-day life. However, these systems deal with severe challenges in security and reliability. Security is important whenever a user communicates or stores sensitive data, e.g., medical information; reliability has to be guaranteed to be able to transmit or store information while noise occurs. Algebraic codes (ACs) are a powerful means to achieve both. Within inCREASE, I will construct and evaluate special codes for security applications and DNA storage. The tasks are structured into three work packages: (1) post-quantum secure code-based cryptosystems, (2) secure key regeneration based on ACs, (3) ACs for DNA-based storage systems. The focus of inCREASE lies on innovative theoretical concepts. The goal of work package (1) is to investigate and design code-based cryptosystems; one promising idea is to apply insertion/deletion correcting codes. The security of these systems will be analysed from two points of view: structural attacks on the algorithms and hardware implementations with side-channel attacks. Secure cryptographic key regeneration is the goal of (2) and can be achieved by physical unclonable functions (PUFs). Here, ACs are necessary to reproduce the key reliably. This project will study the error patterns that occur in PUFs, model them theoretically, and design suitable coding schemes. The investigation on (3) will start with a study of the data of existing DNA storage systems. The outcome will be an error model that will include insertions, deletions, substitutions, and duplications. Therefore, inCREASE will design ACs for these error types. This will be especially challenging regarding the mathematical concepts. These codes will be evaluated by simulations and using data sets of DNA storage systems. This project is high risk/high gain with impact not only to storage and security, but to the methodology as well as other areas such as communications.

Keywords: coding theory,error correcting codes,code based cryptography,coding for dna storage,channel coding
Chrome plating without toxic Cr(VI). An ecofriendly electroplating for automotive plastic parts. (freeCr6plat)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-09-01
End date: 2021-04-30
Duration (months): 32.0
Total project cost (EUR): 1764410.0
EU funding (EUR): 1235087.0
Participants: 1
Project status: CLOSED

Electroplating is one of the most advanced techniques to create plated plastics with wide industrial applications. However, current electroplating techniques use hexavalent chromium (Cr [VI]) as etching agent. Hexavalent chromium has been proved to have toxic, mutagenic and cancerogenic effects for human health. As a result, the European Union has included this compound within the list of restricted substances under the Directive 76/769/EEC (REACH Directive) and banned its use from 2017 onwards, while strengthening environmental, health and safety legislations on hazardous waste. This has left the plating industry in a very delicate position with dark future prospects unless new solutions that are both effective and environmentally friendly are discovered. freeCr6plat is an advanced and demonstrated technology that applies a patented Molecular Self Assembly (SAM) technique for ‘direct metallization’ of a wide variety of plastic surfaces, eliminating the use of Cr (VI) and simplifying the number of steps in the plating process. This allows to reduce the use of chemicals (-30%), rinsing water inputs and wastewater generation and associated treatment (-35%), and energy consumption (-50%), resulting in environmental performance and time (-20%) optimization, while reducing overall plating and wastewater treatment costs by 20% compared to the conventional system. Besides, this technique maintains adhesion promotion within the process, resulting in high quality finishing results comparable to the conventional process. freeCr6plat project aims to reach short term market uptake for automotive applications by adapting the process to automotive plating lines, obtaining specific certifications required by the sector and strengthening our environmental awareness, commercial and networking strategy. We expect Cr6-FreePlat to reach a market penetration from 6% to 16% in five years, with M€105.6 cumulative turnover and M€ 21.1 profits, resulting in a ROI of 8.6.

Keywords: electroplating,chromium,plastics,metallisation