Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Inter-bacterial competition mediated by the type VI secretion system (T6SS): promising role in the biocontrol properties of Pseudomonas putida (BIOCONT6SS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Bacterial type VI secretion systems (T6SSs) are recently discovered nanomachines used to inject effectors into prokaryotic or eukaryotic cells. Therefore, T6SSs are involved in both inter-bacterial competition and bacterial pathogenesis. In this project, I propose to study the T6SS of Pseudomonas putida a soil bacterium with the capacity to colonise the root of crop plants. The colonisation by this bacterium provides growth advantages to the plant and, importantly, protection against plant-pathogens. This makes P. putida a relevant biocontrol agent. Since T6SS is mainly used by environmental bacteria for inter-bacterial competition, one might speculate that T6SSs play a relevant role in the biocontrol properties of P. putida. An in silico analysis of P. putida KT2440 genome revealed the existence of three putative T6SSs: H1, H2 and H3. I have determined that H1-T6SS is active and can be used to kill the serious phytopathogen Pseudomonas syringae. Mutants in H1-T6SS structural components lack the ability to kill model prey strains. In this project, I propose to use these mutants in competition assays with several microorganisms to further identify H1-T6SS targets, especially other resilient phytopathogens such as Agrobacterium tumefaciens and Ralstonia solanacearum. Furthermore, I will assess the role of T6SSs in the biocontrol properties of P. putida using infected plants. Moreover, I have identified novel H1-T6SSs effectors and their cognate immunity proteins (EI pairs) which belong to EI families without functionally characterised members. I will characterise the identified EI pairs at a functional, biochemical and structural biology level. In addition to the fundamental interest of the characterisation of new T6SSs, elucidation of their role in the biocontrol activity of P. putida is entirely original and has not been addressed thus far. Our findings will be highly relevant for future applications in agricultural biotechnology.

Keywords: type vi secretion system,pseudomonas putida,biocontrol,inter bacterial competition,phytopathogens,environmental microbiology,plants,effector immunity proteins
Intelligent data-driven pipeline for the manufacturing of certified metal parts through Direct Energy Deposition processes (INTEGRADDE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Spain,Italy,Spain,Spain,Greece,Sweden,Poland,Slovenia,France,France,France,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom,Portugal
Call: Pilot lines for metal Additive Manufacturing (IA 50%) (H2020-NMBP-FOF-2018, 2018)
Start date: 2018-10-01
End date: 2023-03-31
Duration (months): 54.0
Total project cost (EUR): 16999328.75
EU funding (EUR): 12716173.51
Participants: 30
Project status: SIGNED

The industrialisation of Additive Manufacturing (AM) requires a holistic data management and integrated automation. INTEGRADDE aims to develop an end-to-end Digital Manufacturing solution, enabling a cybersecured bidirectional dataflow for a seamless integration across the entire AM chain. The goal is to develop a new manufacturing methodology capable of ensuring the manufacturability, reliability and quality of a target metal component from initial product design via Direct Energy Deposition (DED) technologies, implementing a zero-defect manufacturing approach ensuring robustness, stability and repeatibility of the process. To achieve this aim, INTEGRADDE addresses following key innovations: - Development of an intelligent data-driven AM pipeline. - Combination of automatic topology optimisation algorithms for design, multi-scale process modelling, automated hardware-independent process planning, online control and distributed NDT for the manufacturing of certified metal parts. - A self-adaptive control is adopted focused on the implementation of non-propagation of defects strategy. Moreover, Data Analytics will provide a continuous refinement by acquiring process knowledge to assist in the manufacturing of new metal components, improving right-first-time production by adopting a mass customization approach - Cybersecurity ensures data integrity along the AM workflow, providing a novel manufacturing methodology for the certification of metal AM parts. INTEGRADDE implements a twofold deployment approach for the pilot lines: both in application-driven at five industrial end-users (steel, tooling, aeronautics, and construction) and open-pilot networks at RTOs already owning AM infrastructure (AIMEN, IREPA, CEA, WEST). This will allow a continuous validation and deployment of specific developments towards industrialization, boosting definitive uptake of AM in EU metalworking sector.

Keywords: directed energy deposition,additive manufacturing,integrated automation,end to end digital manufacturing,cybersecured data driven pipeline,bidirectional dataflow,certified metal components
Nuclear rEaCTions At storage Rings (NECTAR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Obtaining reliable cross sections for neutron-induced reactions on unstable nuclei is a highly important task and a major challenge. These data are essential for nuclear astrophysics -since most of the heavy elements in the Universe are produced by neutron-induced reactions in stars- and for applications in nuclear technology. However, their measurement is very complicated as both projectile and target are radioactive. The most promising way to infer these cross sections is to use surrogate reactions in inverse kinematics, where the nucleus formed in the neutron-induced reaction of interest is produced by a reaction involving a radioactive heavy-ion beam and a stable, light target nucleus. The decay probabilities (for fission, neutron and gamma-ray emission) of the nucleus produced by the surrogate reaction provide precious information to constrain models and enable much more accurate predictions of the desired neutron cross sections. Yet, the use of surrogate reactions is hampered by the numerous long-standing target issues. I propose to solve them by combining surrogate reactions with the unique possibilities at ion storage rings. In a storage ring heavy radioactive ions revolve at high frequency passing repeatedly through an electron cooler, which will greatly improve the beam quality and restore it after each passage of the beam through the internal gas-jet serving as ultra-thin, windowless target. This way, decay probabilities can be measured with unrivaled accuracy. NECTAR aims to develop a detection system based on cutting-edge technology and a new method to measure accurate decay probabilities of radioactive nuclei at the CRYRING storage ring of the GSI/FAIR facility. The extreme vacuum conditions of the ring put severe constraints on the detection setup. I propose original, even revolutionary options to overcome these issues like the use of solar cells. Thus, NECTAR will be the seed of a new generation of nuclear-reaction experiments with unstable beams.

Keywords: indirect measurement of neutron cross sections,surrogate reactions,decay probabilities,nuclear fission,radioactive ion beams,heeavy ion storage rings,solar cells,silicon detectors
Disrupting the real-time medical imaging market, and accelerating innovation, with cloud Platform as a Service (PaaS) (Cydar PaaS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Medical imaging science has progressed greatly in recent years with advances in cloud computing power, computer vision, machine learning and augmented reality. There is global political will to improve the efficiency of healthcare delivery through better exploitation of information technology. But there is surprisingly little translation of research output into clinical systems supporting real-time imaging. Large hardware manufacturers currently dominate the software market for image-guided surgery. Their business model is based on high capital expenditure for installing large equipment that combines hardware and software. But this model means high costs and long lead times for changes, creating high barriers to innovation. Cydar has identified an opportunity to disrupt this model by decoupling software innovation from the hardware. The concept is a dedicated cloud platform that hosts third-party applications, while handling image anonymisation, information security, governance and data storage. The core, tested technology involves a standard PC and web browser securely streaming the live imaging in the operating room to the cloud platform. This business model is cloud Platform as a Service (PaaS), hosting applications for enterprises, healthcare organisations and academic institutions. Revenue streams include hosting fees and fees for access to the stored data for secondary use. Crucially, end-user markets become widely accessible, costs are lowered, lead times slashed and the commercial risks of innovation reduced. The model is readily scalable for the global market. We expect it to accelerate the exploitation of medical digital data for the benefit of citizens, both as patients and as taxpayers.

Keywords: medical imaging,image guided surgery,cloud computing,platform as a service,paas
Platform for Heterogeneous Integration of NEMS on ICs (MaMs2)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2015-07-01
End date: 2016-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Within the ERC-M&M´s Starting Grant project (No.277879) we are exploring an innovative platform technology for wafer-level heterogeneous integration of integrated circuits (ICs) with micro/nano-electromechanical systems (MEMS/NEMS). This type of heterogeneous 3D integration technology is part of the More-than-Moore paradigm depicted in the International Technology Roadmap for Semiconductors (ITRS) and allows the combination of standard CMOS-based integrated circuits and high-performance MEMS devices to form complex and highly integrated systems that are not possible to manufacture with other micro-manufacturing approaches. First heterogeneous integration platforms for IC-integrated MEMS products have already been commercialized with great success by InvenSense (USA) and by mCube (USA) in collaboration with TSMC (Taiwan), the world’s largest CMOS foundry. However, the established heterogeneous integration technologies have limitations with respect to the type of MEMS devices that can be realized and the extent to which the MEMS-ICs system component can be miniaturized. The heterogeneous integration platform developed in this ERC-M&M’s+2 Proof of Concept proposal is suitable for a variety of small-sized MEMS components with large-volume markets, including infrared (IR) detector arrays, micro-mirror arrays, ultra-low power circuits based on NEM switches (a specific target application are low-power FPGAs), gyroscopes, accelerometers, microphones, etc. Thus, the heterogeneous integration platform is addressing a potential multi-billion € market. In contrast to the competing technologies, our heterogeneous integration platform is enabling the integration of ICs and MEMS/NEMS devices with extremely small device dimensions in the nm-range, very small via dimensions in the sub-1μm-range and placement accuracies of the MEMS/NEMS components on the target ICs in the nm-range.

Keywords: heterogeneous mems integration,nems,mems foundry,ir imaging,nems switch
NEXT generation civil Tilt Rotor Interactional aerodynamic tail oPtimisation (NEXTTRIP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Italy,Netherlands,Netherlands,Netherlands
Call: Interactional aerodynamic assessment of advanced Tilt Rotor configuration (H2020-CS2-CFP06-2017-01, 2017)
Start date: 2018-03-01
End date: 2020-08-31
Duration (months): 30.0
Total project cost (EUR): 2777222.5
EU funding (EUR): 2582756.9
Participants: 6
Project status: CLOSED

The aerodynamic configuration definition of the NGCTR needs to be confirmed by a large scale powered wind tunnel experiment, with the aim to verify and confirm the key choices of the configuration and to provide guidelines and proposals for potential additional improvement to be implemented. Within the EU 6th framework programme NICETRIP a 1/5th scale full-span, powered wind tunnel model has been designed and manufactured by NLR and tested in DNW-LLF and ONERA S1, with support of DLR. In order to fully exploit the FP6 research program, NEXTTRIP is a 30 month- 2.77 MEuro valued project based on re-using the existing NICETRIP powered model and key-partners responsible for the successful execution of the NICETRIP low speed test. The NEXTTRIP partners, NLR, DNW, DLR, Hit09 & Fokker will work together to modify the NICETRIP model, perform the wind tunnel test in DNW-LLF and define an optimal Empennage configuration based on the wind tunnel test results and given boundaries. NLR will coordinate the NEXTTRIP project and will perform wind tunnel model design and manufacture, test preparations (including GVT), advanced flow visualisation during wind tunnel test and wind tunnel data analysis. DNW will support test preparation and perform the wind tunnel test. DLR will support test preparation and perform data-acquisition and piloting. Multi-objective aerodynamic empennage optimisation will be performed by Hit09 after wind tunnel data analysis. Fokker will, together with NLR, perform a verification of compliance with feasibility and industrial constraints during the empennage optimisation process. For all three empennage configurations, both powered and unpowered test will be performed and for a selected configuration advance flow visualisation will be performed for a better understanding of the interactional aerodynamic phenomena.

Keywords: tilt rotor,tail,optimisation,aerodynamic,empennage,wind tunnel test
Commercialisation of novel ultra-fast 3D laser scanning technology (3DSCAN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-06-01
End date: 2020-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Understanding how the brain processes information is one of the unsolved grand challenges in science. Moreover, neurological disorders, which disrupt information processing, have an enormous societal and economic impact. Studying information processing in the brain requires measurements of signals as they flow through neural circuits. However, the 3D nature of brain circuits and the speed of information transfer makes it difficult for neuroscientists to measure their properties with sufficiently high spatial and temporal resolution. During the NEUROGAIN ERC project, we developed a novel type of Acousto-Optic Lens (AOL)-based high-speed 3D laser scanner. This technology enables the focusing and scanning of a laser beam at 20-40 kHz. This scanning technology can be added to existing two-photon microscopes to enable 3D imaging of neurons and circuits with unprecedented spatio-temporal resolution. Moreover, it also automatically corrects for brain movement in real-time providing sharper images. This ERC PoC will facilitate commercialization of this 3D scanning technology by providing support to explore the markets in biosciences and beyond, protect the IP and facilitate early stage manufacture and assembly of AOL 3D scanners to supply biomedical researchers.

Keywords: two photon imaging,brain function,laser scanning,circuit,neuron,synapse
COOK-SAFE: A Safer, Non-stick, Antibacterial and Heat-stable Nanocoating for Cookware and Household Appliances. (COOK-SAFE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

While the demand for non-stick cookware and household appliances has been increasing worldwide, there are even greater concerns over the safety of non-stick coatings. Most of these non-stick surfaces are coated with Teflon, with 90% of all aluminium cookware sold coated with Teflon. Tests show that when Teflon-coated pans and appliances are heated above 6800F, toxins are produced, including the likely carcinogens polytetrafluoroethylene (PTFE) and perfluorooctanoic acid(PFOA). PFOA is linked to a range of health problems, including thyroid disease, infertility in women and organ damage as well as developmental and reproductive problems in lab animals. Toxic fumes released from heated cookware and appliances may kill pet birds and cause people to develop flu-like symptoms, called “Polymer fume fever” or “Teflon Flu”. Manufacturers’ labels warn consumers to avoid high heat on Teflon-coated appliances, but recent tests show that in just two to five minutes, cookware or surfaces coated with Teflon could exceed temperatures at which the coating breaks apart and emits toxic gases. Alternative coatings exist on the market today but no solution exists that is non-stick, stable at high temperature and completely safe. Consequently, Pramar is developing a safe, stable nanocoating for use in the appliances and cookware markets. Our product will impact Europe and the world by reducing the use of raw materials through miniaturisation, reducing the energy and CO2 emissions by 60% and self-cleaning properties help save energy, water and chemicals used in cleaning. This project will greatly benefit our company through a new range of non-stick, enamelled appliances (new generation of our current products), allowing us to increase our turnover by 50% over a 5-year period. In addition, and through licensing, manufacturers of cookware and household appliances will be able to fulfil their social and environmental responsibility using COOK-SAFE.

Keywords: antimicrobial coating,safe cooking,coated cookware,safe household appliances,heat stable cookware,food contaminants,food safety
The Spanish Telecommunication Sector and the Development of AI Products from a Gender Perspective (TELAIGEN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

The rise of algorithm-powered technology in the telecommunications industry has been criticised for reproducing gender bias, particularly in Artificial Intelligence-driven (AI) products. This interdisciplinary and intersectoral project explores the gender bias within the Spanish telecommunications industry as a direct consequence of the lack of women in the sector. The purpose is to develop a multi-methodological study that allows to draw attention and evidence the gender gap and the consequent lack of a gender perspective within this industry in Spain. The central hypothesis is that the current gender gap in the sector leads to lack of integration of a gender perspective leading consequently, to the reproduction of gender bias in AI technologies. This, as a result, produces a setback in gender equality. To explore this, the study asks the following questions: what is the degree of the gender gap within the telecommunications industry in Spain? Are measures being taken to address this? To answer these questions, I will gather data on two levels: first, at the general level by implementing a quantitative survey-based methodology, targeting 400 industry insiders to gain information on the gender gap in the overall sector; and second, at the specific level, by carrying out a case-study through my secondment at Telefónica, Investigación y Desarrollo (TID), a Spanish leading research centre in new technologies where I will use qualitative-based methodologies to investigate its gender bias and its lack of integration of a gender perspective. A major outcome of this research is the production of a report to be handed to TID with specific guidelines for the incorporation of a gender perspective that will help them reduce their gender bias in their AI technologies and improve the commercialisation of their products. This report will have the potentiality of becoming a benchmark study for further research in the field, particularly within the European context.

Keywords: gender perspective,telecommunications sector,artificial intelligence,gender bias