Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Engineering Silicon Carbide Nanowires for Solar Fuels Production (Solarfuels)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-28
End date: 2017-08-27
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

By 2020, the European Union aims to reduce greenhouse gas emissions by 20-30% and increase renewable energy share to 20%. This scenario has imposed urgent needs to develop fossil fuel alternatives like solar fuels. In order to produce solar fuels, the coupled reduction of CO2 and H2O is one of the most promising processes. However, the generation of efficient, stable and low-cost material for CO2/H2O reduction remains a big challenge. Silicon carbide nanowires (SiC NW) exhibit the unique properties of large surface-to-volume ratio, tuneable transport properties and quantum size effects, which is very promising for the reduction of CO2/H2O to produce solar fuels. To date, the studies on SiC NW for CO2/H2O reduction are limited due to the lack of (1) large-scale production techniques, (2) in situ characterization of the growth mode, and (3) there are no economical devices available for the evaluation of SiC NW. This project, SOLARFUELS, proposes the engineering of SiC NW for solar fuels production through the development of a carbon nanotube template method for large-scale synthesis of SiC NW combing with in situ characterization of SiC NW during growth and post-mortem. Design of an economically viable device is envisaged to exploit the in house generated SiC NWs. By introducing novel multiple sample holders for atmospheric gaseous reaction, the designed device can enable efficient catalyst/reactant contact along the vertically orientation of SiC NW and reduce the cost for the device by at least a half.The SOLARFUELS is built across research areas of materials science, chemistry, chemical and device engineering. It perfectly integrates the Experienced Researcher (ER)’s skills in solar energy application/device development and the Supervisor’s expertise in nanomaterials synthesis/characterization. It will play an important role in advancing ER's career for a permanent position and in addition it will contribute to new approaches to further host's solar fuel research.

Keywords: silicon carbide,nanowire,solar fuels,carbon dioxide reduction,water splitting
Control of cerebral blood flow by capillary pericytes in health and disease (BrainEnergy)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-09-01
End date: 2024-02-29
Duration (months): 78.0
Total project cost (EUR): 2499954.0
EU funding (EUR): 2499954.0
Participants: 1
Project status: SIGNED

Pericytes, located at intervals along capillaries, have recently been revealed as major controllers of brain blood flow. Normally, they dilate capillaries in response to neuronal activity, increasing local blood flow and energy supply. But in pathology they have a more sinister role. After artery block causes a stroke, the brain suffers from the so-called “no-reflow” phenomenon - a failure to fully reperfuse capillaries, even after the upstream occluded artery has been reperfused successfully. The resulting long-lasting decrease of energy supply damages neurons. I have shown that a major cause of no-reflow lies in pericytes: during ischaemia they constrict and then die in rigor. This reduces capillary diameter and blood flow, and probably degrades blood-brain barrier function. However, despite their crucial role in regulating blood flow physiologically and in pathology, little is known about the mechanisms by which pericytes function. By using blood vessel imaging, patch-clamping, two-photon imaging, optogenetics, immunohistochemistry, mathematical modelling, and live human tissue obtained from neurosurgery, this programme of research will: (i) define the signalling mechanisms controlling capillary constriction and dilation in health and disease; (ii) identify the relative contributions of neurons, astrocytes and microglia to regulating pericyte tone; (iii) develop approaches to preventing brain pericyte constriction and death during ischaemia; (iv) define how pericyte constriction of capillaries and pericyte death contribute to Alzheimer’s disease; (v) extend these results from rodent brain to human brain pericytes as a prelude to developing therapies. The diseases to which pericytes contribute include stroke, spinal cord injury, diabetes and Alzheimer’s disease. These all have an enormous economic impact, as well as causing great suffering for patients and their carers. This work will provide novel therapeutic approaches for treating these diseases.

Keywords: pericyte,capillary,stroke,alzheimer s,cerebral blood flow
From mechanical stress to vascular fate (MechanoFate)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2016-01-01
End date: 2021-06-30
Duration (months): 66.0
Total project cost (EUR): 1498412.5
EU funding (EUR): 1498412.5
Participants: 1
Project status: CLOSED

In the vascular system, cell phenotype and fate are driven by the mechanical environment. Whereas physiological mechanical stress defines and stabilizes normal cell phenotype, aberrant mechanical signals trigger phenotypic alteration, leading to inflammation and vascular remodelling. Despite recent advances, how mechanical cues impact gene expression to specify cell phenotype remains poorly understood. Our hypothesis is that mechanical stresses are transmitted to the nucleus where they activate signaling pathways, which in turn regulate gene expression, but what are these mechanotransduction mechanisms occurring within the nucleus? Besides, while most vascular cells respond to mechanical force, Resident Stem Cells (RSCs) are virtually insensitive and remain undifferentiated despite constant cyclic stretch. What are the molecular mechanisms which protect RSCs from stretch-induced differentiation? To answer these questions, we designed an interdisciplinary proposal which gathers biophysical, biochemical and genetic assays, with the following objectives: I) To determine how nuclear mechanotransduction pathways regulate vascular cell phenotype in response to mechanical cues. By combining proteomic and biophysical assays, we will identify nuclear proteins that are post-translationally modified in response to mechanical stress, then we will determine their contribution to gene expression regulation and vascular cell differentiation. II) To identify the molecular mechanisms which protect RSCs from stretch-induced differentiation. We will identify differentially expressed force-bearing structural elements in RSCs compared to more differentiated vascular cells and we will evaluate their impact on gene expression, stress transmission, RSC differentiation and blood vessel formation.The proposed project will yield new insights in different areas of life science from cell biology to potential identification of new therapeutic targets in cardiovascular and regenerative medicine.

Keywords: mechanotransduction,mechanical stress,nucleoskeleton,extracellular matrix,smooth muscle cell
Innovative approach for self-management and social welfare of Cystic Fibrosis patients in Europe: development, validation and implementation of a telematics tool. (MyCyFAPP)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Spain,Germany,Belgium,Norway,Netherlands,Portugal
Call: Self management of health and disease: citizen engagement and mHealth (H2020-PHC-2014-single-stage, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 5087507.5
EU funding (EUR): 5087507.0
Participants: 13
Project status: CLOSED

Cystic Fibrosis (CF) is a genetic disease with the higher incidence in Europe showing c.a. 5% mortality in childhood. The majority of patients suffer from lifelong pancreatic insufficiency leading to maldigestion of food and malabsorption and consequently with malnutrition and growth stunting. An accurate enzyme replacement arises as an early nutritional intervention able to provide better nutritional status and patients’ welfare from early stages avoiding complications associated to the development of the disease. By means of our innovative and portable ICT tool we will improve the socio-economic impact of the disease, promoting healthy lifestyle, intertwining patient empowerment, education and training with self-management and prevention of secondary CF-complications. The multidisciplinary and complementary approach of this co-developed integrative PROJECT guarantees the patient’s adherence to the treatment and the best outcome of the nutritional intervention mainly in childhood. The beneficiaries of the application comprise patients, care-givers, families and health professionals as well as health monitoring authorities. MyCyFAPP is tailored designed and will be clinically validated for CF self-management and monitoring becoming a competitive market product in Europe. This APP will have a key role as decision support system, boosting the growth and competitiveness of the participating SMEs in Europe which will ensure the commercial exploitation of the results, the market uptake and the MyCyFAPP distribution for the benefit of the patient.

Keywords: mhealth,cystic fibrosis,gastroenterology,self management,nutrional inverventions,ict tool
CRITICAL APPROACHES TO POLITICS, SOCIAL ACTIVISM, AND ISLAMIC MILITANCY IN THE WESTERN SAHARAN REGION (CAPSAHARA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Portugal
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2021-12-31
Duration (months): 57.0
Total project cost (EUR): 1192144.0
EU funding (EUR): 1192144.0
Participants: 2
Project status: CLOSED

This project proposes an analysis of the reconfigurations established in the socio-political vocabulary of the western Saharan region – southern Morocco, Western Sahara and Mauritania – from the “post-empire” to the contemporary period. The project should produce an analysis of 1) the social and political structures shared in the region, 2) the local variations of those structures, based on case studies, 3) their specific configurations, based on social markers such as gender, age, and class, 4) the use of those structures in different historical periods. All these will be under theoretical and ethnographic scrutiny in order to achieve its main goal: 5) to understand the recent articulation of the social and political structures of the Western Saharan region, with broader and often exogenous political vocabularies. The methodology used in this project is based on readings associated with different social sciences, with a particular focus on anthropology, history, and political science. The members of the research team, with experience and linguistic competence in the different geographies involved in this project, are expected to conduct original field enquiries, enabling a significant enhancement of the theoretical and ethnographic knowledge associated with this region. The project’s main goal is to analyse the types of interplay established between pre-modern socio-political traditions and contemporary political expression and activism, in a particularly sensitive – and academically disregarded – region. Its effort to integrate a context that is usually compartmentalized, as well as to put together a group of researchers generally “isolated” in their particular areas of expertise, geographies, or nations, should also be valued. The project’s results should enable the different contexts under study to be integrated into the wider maps of current scientific research, providing, at the same time a dissemination of its outputs to an extended audience.

Keywords: social activism,islamic culture
Programmable Atomic Large-Scale Quantum Simulation (PASQuanS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Tackling grand interdisciplinary science and technology challenges
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Austria,Germany,Austria,Germany,Germany,Switzerland,France,France,France,France,France,United Kingdom
Call: FET Flagship on Quantum Technologies (H2020-FETFLAG-2018-03, 2018)
Start date: 2018-10-01
End date: 2022-03-31
Duration (months): 42.0
Total project cost (EUR): 9659515.0
EU funding (EUR): 9257515.0
Participants: 20
Project status: CLOSED

PASQuanS will perform a decisive transformative step for quantum simulation towards programmable analogue simulators addressing questions in fundamental science, materials development, quantum chemistry and real-world problems of high importance in industry. PASQuanS builds on the impressive achievements of the most advanced quantum simulation platforms, based on atoms and ions. The neutral-atom simulators handle more than 50 cold atoms in optical lattices or arrays of optical tweezers, interacting via either collisional or Rydberg-state-mediated interactions. The ion-trap platform reaches unsurpassed control with up to 20 ions. By scaling up these platforms towards >1000 atoms/ions, by improving control methods and making these simulators fully programmable, PASQuanS will push these already well-advanced platforms far beyond both the state-of-the-art and the reach of classical computation. Full programmability will make it possible to address quantum annealing or optimization problems much sooner than digital quantum computation. PASQuanS will demonstrate a quantum advantage for non-trivial problems, paving the way towards practical and industrial applications. PASQuanS tightly unites five experimental groups with complementary methods to achieve the technological goals, connected with six theoretical teams focusing on certification, control techniques and applications of the programmable platforms, and five industrial partners in charge of the key developments of enabling technologies and possible commercial spin-offs of the project. PASQuanS will result in modular building blocks for a future generation of quantum simulators. Possible end-users of these simulators, major industrial actors, are tightly associated with the consortium. In a cross-fertilization process, they will be engaged in a dialogue on quantum simulation, and help to identify and implement key applications where quantum simulation provides a competitive advantage.

Keywords: quantum simulation,annealing,quantum advantage,ultracold atoms,trapped ions,rydberg atoms,quantum many body physics,optimisation problem,industrial applications of quantum technologies
Perpendicular Magnetic Anisotropy: from Topological Defects to Reconfigurable Magnetic Devices (MAGTOPRECON)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The present project aims to explore and control the behavior of magnetic topological defects in weak Perpendicular Magnetic Anisotropy materials by creating different hard/soft magnetic nanostructures with reconfigurable properties.Both, static and dynamic behaviors will be exploded and finally, a demonstration device will be prepared: a reconfigurable magnonic crystal with potential applications in information and communication technologies.Weak perpendicular magnetic anisotropy materials present fascinating magnetic stripe domain arrangements sharing phenomenology with other self-organized systems.These magnetization configurations can be understood as a 2D magnetic crystal.Topological defects within the stripes’ lattice condition and drive the magnetization processes of the system being their study a key factor for both, fundamental and technological goals. One of the objectives of the project is to go a step further in the study of magnetic topological defects in these systems. We want to characterize, with unprecedented detail, the behavior of magnetization textures and control their evolution by locally tuning the film properties.Not only static properties will be analyzed, but also the dynamics. It will allow to observe interesting spin wave phenomena, and ultimately, to identify and excite the dynamic modes of topological defects.To achieve this, a unique combination of ferromagnetic resonance with Lorentz Transmission Electron Microscopy will be used, with guidance from micromagnetic simulations. On the other hand, the aforementioned system can be used as key element in the development of low energy consumption reconfigurable magnetic devices. We want to demonstrate it by creating a reconfigurable magnonic crystal combining patterned soft magnets and weak perpendicular magnetic anisotropy elements. The work will mainly be conducted at the University of Glasgow, with some fabrication performed at University of Oviedo in Spain, over a period of 2 years.

Keywords: weak perpendicular magnetic anisotropy,magnetic topological defects,lorentz microscopy,magnetization dynamics,spin waves,reconfigurable magnetic devices
Non-histone protein acetylation targets of KAT2A in AML (ProMeta)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The importance of an insight into how cell fate is established and maintained, extends far beyond the interests of developmental biology. It is pivotal to our understanding of how these processes can be hijacked and deranged in diseases such as cancer, or of the factors involved in reprogramming cell identity and function. Acute Myeloid Leukaemia (AML) has a dismal prognosis with less than 30% 5-year survival. Mainstay therapy has remained essentially unchanged for the past three decades, with all small advances in disease-free survival attributable to transplantation and improved supportive care. Only recently PKC412 has received Food and Drug Administration (FDA)’s break through therapy designation for the FLT3-ITD+ AML. This paves the way for investigation considering that FLT3-ITD as a driving oncogenic mutation has been found in ~30% of the AML patients. The pathogenesis of AML is heterogeneous, but there are common themes of epigenetic, transcriptional and signalling dysregulation that contribute to the resulting clonal expansion of blasts at different stages of maturation, and accompanying bone marrow failure. A significant number of the most commonly mutated targets in AML are histone modifiers, i.e. proteins or complexes that catalyse post-translational modifications in specific residues of the histone side chains. A less studied acetyltransferase, but crucially implicated in AML is KAT2A, the first histone acetyl-transferase (HAT) identified in yeast.GCN5 also acetylates the AML1/MDS1/EVI1 fusion protein in rare cases of AML.KAT2A regulates the activity of Peroxisome Proliferator- Activated Receptor Gamma-Coactivator-1α and B through protein acetylation. The goal of this proposal is to explore the role of KAT2A in Acute Myeloid Leukaemia (AML) through investigation of its non-histone protein acetylation activity.

Keywords: cancer,kat2a,metabolomics,mass spectrometry,non histone proteins,nuclear magnetic resonance
Decrease Jet-Installation Noise (DJINN)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Belgium,France,France,France,United Kingdom,United Kingdom,United Kingdom
Call: Advancements in aerodynamics and innovative propulsion systems for quieter and greener aircrafts (H2020-MG-2019-TwoStages, 2019)
Start date: 2020-06-01
End date: 2023-11-30
Duration (months): 42.0
Total project cost (EUR): 4995210.0
EU funding (EUR): 4995210.0
Participants: 13
Project status: SIGNED

With the aim of reducing the environmental impact of noise caused by aircraft during take-off, the prediction and mitigation of jet-airframe interaction noise sources remain significant challenges for closely integrated propulsion-airframe architectures. The ambition of the DJINN project is therefore to develop a new generation of reliable computational fluid dynamics (CFD) methods, most of them belonging to the field of hybrid methods, for assessing promising noise-reduction technologies, with support and validation from reduced-scale experiments. This key ambition is tied to the provision of advanced tools for coupled aerodynamics-aeroacoustics to enable design optimisation in future industrial environments and to reach a new level of noise reduction through a highly collaborative effort. The DJINN project denotes a breakthrough in designing quieter and greener aircraft through both improved CFD methods and better physical understanding. The ability to understand, model and predict jet-airframe noise is the key to conceive efficient noise reduction technologies and optimise future industrial designs. Important noise reductions of future integrated propulsion aircraft are foreseen with 5 dB reduction of the jet-airframe interaction noise peak level at low frequencies. This objective cannot be reached by investigating the engine/nozzle and airframe systems separately. Improved CFD methods for multi-physics modelling utilizing high-performance computing are expected to reduce design times and costs by around 25% compared to large-scale testing. The DJINN project will make a major impact on economic and environmental factors and secure the leadership of the European aeronautics industry in the highly competitive global market. The consortium is formed by major industrial aeronautical companies, well-known research organisations and academic groups, with an SME acting as the coordinator.

Keywords: jet airframe interaction noise,noise reduction,uhbr,hybrid cfd methods