Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Contextualising psychosocial wellbeing and mental health within sociocultural dynamics (PSYCHOCONTEXT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-06-01
End date: 2019-07-05
Duration (months): 36.0
Total project cost (EUR): 239191.2
EU funding (EUR): 239191.2
Participants: 2
Project status: CLOSED

The lack of contextualization of the science and applications of mental health is the source of a large part of its criticisms. From the lack of research on how social dynamics influence the well-being of citizens, to the gaps in research and coordinated implementation of different disciplines involved in mental health in a changing environment, there are still many limitations for a contextualised and integrated view. This project intends to offer a bottom-up, source-embedded appreciation of the need to effectively seek to contextualise mental health interventions and the professional and institutional barriers to this process at the international level, using participatory research methods with practitioners and users of psychological services as well as the general population trough personal as well as digital contact. The first milestone of the project will be an empirical study on how sociocultural dynamics impact psychosocial wellbeing and mental health integrating a website and a mobile application with face to face interviews. The second will intend to gather information on approaches already used which can be considered contextualised. The results of both milestones will be used to organise continuing professional development workshops with mental health professionals, in which focus groups will be used to explore the perceived need and institutional obstacles for contextualisation.

Keywords: mental health,psychosocial wellbeing,sociocultural dynamics,service users,participation,citizenship
Innovation Systems in Financial Crisis: Technological Dynamics, Industrial Structure and Business Cycles (cRISys)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

This research project will investigate from an empirical, theoretical and normative perspective the impact of financial crisis on innovation systems, and in particular knowledge networks and technology clusters, and by extension, on technological trajectories, industrial dynamics and economic growth of afflicted EU economies. It will also explore the latent link between technological dynamics and business cycles, and examine to what extent a strategic mix of RTDI, industrial and regional policies can address structural causes of crises and foment techno-economic development by building the capacities of innovation systems and bridging the technology gap. The project will apply econometric modelling, network analysis, and computational simulations at various geographical scales, from NUTS-3 regions to the EU as a whole, focusing on three Southern European countries (Spain, Portugal and Greece). At the theoretical level, it aspires to bridge the gap between neo-Schumpeterian technological dynamics and post-Keynesian macroeconomics with endogenous fluctuations, and to build an agent-based model of an innovation system for policy simulation. This is expected to shed light on the latent link between business cycles and technology gaps, to gauge the technological impact of financial crises, and to assess alternative policy responses under different institutional settings. The project is highly topical in the context of post-crisis EU policy discourse on the future of ERA, the Innovation Union initiative and Europe 2020 growth strategy, and it can advance the design of ‘knowledge governance’ policy instruments for crisis-hit EU periphery, thus having a positive societal impact. It is also designed to boost the researcher’s academic career restart, to consolidate his expertise in the field of innovation and technology economics, and to enrich his research skills by providing advanced training and opportunities for international research collaborations and dissemination.

Keywords: innovation systems,financial crises,business cycles,technological development,industrial policy,evolutionary economics,post keynesian macroeconomics,agent based modelling
Self-Organization of the Bacterial Cell (SELFORGANICELL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Austria
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2021-03-31
Duration (months): 60.0
Total project cost (EUR): 1496686.99
EU funding (EUR): 1496686.99
Participants: 1
Project status: CLOSED

One of the most remarkable features of biological systems is their ability to self-organize in space and time. Even a relatively simple cell like the bacterium Escherichia coli has a precisely regulated cellular anatomy, which emerges from dynamic interactions between proteins and the cell membrane. Self-organization allows the cell to perform extremely challenging tasks. For example, for cell division, more than ten different proteins assemble into a complex, yet highly dynamic machine, which controls the invagination of the cell while constantly remodeling itself. Although the individual components involved have been largely identified, how they act together to accomplish this challenge is not understood. It has become clear that sophisticated biochemical networks give rise to intracellular organization, but we have yet to uncover the underlying mechanistic principles. In this research proposal, I aim to develop a detailed mechanistic understanding of the self-organizing, emergent properties of the cell. To this end, my research group will develop novel in vitro reconstitution experiments combined with high-resolution fluorescence microscopy and theoretical modeling. Following this “bottom-up” approach, we will quantitatively analyze collective protein dynamics and emergent mechanochemical properties of the bacterial cell division machinery. I aim to answer the following fundamental questions: 1) What is the biochemical network giving rise to the dynamic assembly of the divisome? 2) How do the components of the divisome interact to generate force? 3) How do peptidoglycan synthases build the cell wall? By comparing protein dynamics in vitro with those measured in vivo, we will provide a link between molecular properties and the processes found in the living cell. This project will not only improve our understanding of the bacterial cell, but also open new research avenues for eukaryotic cell biology, synthetic biology and biophysics.

Keywords: self organization,synthetic biology,in vitro reconsitution,bacterial cell biology
Disruptive Cyclone-based technology for effective and affordable particulate matter emission reduction in biomass combustion systems (CYCLOMB)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Spain,Italy,Spain,Denmark
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2016-1, 2016)
Start date: 2017-04-01
End date: 2020-11-30
Duration (months): 44.0
Total project cost (EUR): 1640773.76
EU funding (EUR): 1241826.2599999998
Participants: 4
Project status: CLOSED

A strong complementary team with more than 70 years' experience has come together to upgrade, scale-up and market launch an urgently needed affordable integrated solution for emission reduction for biomass combustion plants (CYCLOMB), which will generate 26.54M€ of cumulative profit and 97 new direct jobs by 2023. All EU countries will have to abide by new regulations (already implemented in Germany, Denmark and UK, other EU member states have to follow until 2030) which fix particulate matter (PM) emission limits under 20 mg/m3. Today no cost effective solutions exist that comply with the legislation. The CYCLOMB system achieves a 96-99% PM emission reduction, combining flue gas recycling and cyclone variable geometry. Recirculation of flue gases provides the biomass boiler with a high combustion efficiency (up to 95%) and reduces boiler emissions from 150 mg/m3 of typical automatic boilers to 80 mg/m3. By using a variable-geometry design of the attached PM abatement device a ≥96-99% particulate matter reduction is achieved. Final emission levels are always lower than 20 mg/m3 while investing only an additional 26% in PM abatement technology with respect to boiler price. It thus provides a comparative performance to the most advanced electrostatic precipitators and bag filters but at a 66% lower cost. The total annual operation and maintenance cost of biomass power plants is typically 5%-6.5% of the capital cost of small and medium capacity power plants. The implementation of CYCLOMB can reduce these maintenance costs at least 80% The PM abatement cyclone-technology solution will be optimized for the CYCLOMB integrated solution medium-scale range (200kW-5MW) ideal for medium scale district heating plants and applications in the primary sector (farms, greenhouses) and the tertiary sector (office buildings, schools, hospitals and hotels).

Keywords: biomass,boiler,cyclon,particulate matter,sustainable combustion,emission reduction,flue gas recycling
Sliceable multi-QAM format SDN-powered transponders and ROADMs Enabling Elastic Optical Networks (QAMeleon)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Germany,Italy,Germany,Italy,Greece,Belgium,Switzerland,Sweden,Greece,France,Netherlands,Denmark,United Kingdom
Call: Photonics KET 2017 (H2020-ICT-2017-1, 2017)
Start date: 2018-01-01
End date: 2022-10-31
Duration (months): 58.0
Total project cost (EUR): 7999558.75
EU funding (EUR): 7999558.75
Participants: 17
Project status: SIGNED

Sustained 2-digit growth in internet traffic is raising the need for new photonic technologies enabling Petabit/s network capacities, whereas suppressed operator margins call for new concepts to make these networks more efficient. QAMeleon aims at a holistic solution towards scaling metro/core networks to the next decade. A new generation of SDN-programmable photonic components, modules and subsystems will be delivered, employing sliceability as a means of optimizing resource utilization and cutting operator costs by >30%. At the transponder side, QAMeleon will develop components for 2 generations ahead: Operating at 128 Gbaud, they will bring significant savings in footprint (>13×), energy/bit (10.4×) and cost/bit (>4.3×). At the ROADM side, QAMeleon will develop large-scale flex-grid wavelength-selective switches (1×24 WSS) and transponder aggregators (8×24 TPA), reducing footprint and cost/port by more than 40% and 28% respectively, with energy savings per ROADM node reaching 4×. Addressing the emerging needs of 5G network backhaul and datacenter interconnect (DCI) metro-access networks where dynamicity is pivotal, QAMeleon will develop an integrated flex-grid 1×4 WSS with nanosecond-scale switching time. The fast 1×4 WSS will be scalable to large channel counts (i.e. full C-band) and will enable savings in footprint, energy consumption and cost by 20×, 11.5× and 36% respectively. QAMeleon will integrate its innovative photonic components into functional subsystems: A 3 Tb/s sliceable bandwidth-variable transponder (S-BVT), a flexible ROADM with large-scale WSSs and TPAs, and a fast ROADM for metro-access. All necessary SDN software extensions, plugins and application interfaces will be developed, providing a complete functional SDN framework for the sliceable “white box” subsystems. QAMeleon’s devices will be integrated with the SDN software and validated in scalable demonstrators at Nokia’s lab infrastructure and on TIM’s deployed regional network fiber plant

Keywords: software defined networking,optical transport networks,coherent transponders,reconfigurable add drop multiplexers,photonic integrated circuits
Multi-Owner data Sharing for Analytics and Integration respecting Confidentiality and Owner control (MOSAICrOWN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Ireland,Italy,Belgium,France,United Kingdom
Call: Supporting the emergence of data markets and the data economy (H2020-ICT-2018-2, 2018)
Start date: 2019-01-01
End date: 2021-12-31
Duration (months): 36.0
Total project cost (EUR): 3203750.0
EU funding (EUR): 3203750.0
Participants: 7
Project status: CLOSED

The application of data analysis techniques over large data collections provides great benefits, from the personal, to the business, research, and social domain. The availability of large data collections recording actions and choices of individuals and organisations can lead to great improvement in the understanding of how the world operates. The continuous evolution of ICT is enabling the realisation of such vision at a fast pace, supporting the realisation of architectures enabling collaborative data sharing and analytics. A clear obstacle towards the realisation of such potential and vision is represented by security and privacy concerns. Indeed, the (actual or perceived) loss of control over data and potential compromise of their confidentiality can have a strong detrimental impact on the realisation of an open framework for enabling the sharing of data from multiple independent data owners. The goal of MOSAICrOWN is to enable data sharing and collaborative analytics in multi-owner scenarios in a privacy-preserving way, ensuring proper protection of private/sensitive/confidential information. MOSAICrOWN will provide effective and deployable solutions allowing data owners to maintain control on the data sharing process, enabling selective and sanitised disclosure providing for efficient and scalable privacy-aware collaborative computations. MOSAICrOWN Consortium sees the participation of major industry players, providing strategic use cases with strong exploitation and impact, and of an SME supporting deployment and standardisation.

Keywords: data protection,efficient and scalable privacy aware collaborative computations,data market
Force Fields in Redox Enzymatic Catalysis (Fields4CAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain,United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2019-03-01
End date: 2025-02-28
Duration (months): 72.0
Total project cost (EUR): 1998700.0
EU funding (EUR): 1998700.0
Participants: 2
Project status: SIGNED

Fields4CAT aims to identify the nature and directionality of the driving forces in a redox enzyme that govern the catalytic chemical process. Industrial bio-manufacturing is one of the pillars of today’s world economy making its way to a sustainable development. Redox enzymes catalyze the most demanding chemical reactions under mild conditions, such as the oxy-functionalization of non-activated hydrocarbons, which usually requires harsh reaction conditions. Enzyme Biotechnology has greatly progressed thanks to rational mutagenesis schemes that draw upon the static X-ray structural information. The high complexity of enzymatic catalysis has, however, hampered its development because a single point mutation near the active site can affect several relevant parameters at the same time, obscuring the interpretation and constraining the rational design of technological biocatalysts. Fields4CAT proposes dissecting the relevant forces exerted over an individual catalytic active site in its wild-type state, and then using the resulting forces map to design enzyme/metal platforms with enhanced capabilities. To this aim, it develops in 3 blocks organized in a step-wise fashion: (i) block 1 sets up a electrochemical multi-stimuli single-protein toolbox (Ec-SPT) with capabilities to trap individual proteins in a nanoscale tunnelling junction and subject them to a variety of force stimuli, i.e. mechanical, electrostatic and magnetic. (ii) Block 2 designs the chemical electrical plugs that will specifically connect the enzyme to the junction electrodes with precise controlled orientation. (iii) Block 3 characterizes the single-protein electrical signatures of the enzyme activity and quantifies the catalytic effect of the different force stimuli along the vertical junction axis. Fields4CAT will identify new guidelines to bioengineer a redox enzyme/metal platform with tuned catalytic activity, bringing about new breakthroughs in the future of Bio-Catalysis.

Keywords: nano bioelectronics,single molecule biophysics,single protein junctions,nanoscale molecular devices,molecular nanoscience
The downward impact of the stratosphere in current and future climates (stratoIMPACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-08-01
End date: 2023-11-30
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: SIGNED

One of the most striking long-lived influences on the weather in Europe comes from the stratosphere, a highly-stratified layer of the atmosphere starting at about 10 km above the surface. The stratosphere impacts surface weather through coupling between the stratospheric polar vortex and the tropospheric jet streams: Extreme events in the stratosphere, so-called sudden stratospheric warmings, tend to be followed by an equatorward shift of the North Atlantic jet stream and significant changes in weather patterns over Europe, including cold spells over Scandinavia and increased rainfall over the Mediterranean. It is however unclear how the coupling between the stratosphere and the troposphere will change in a future climate. Projections demonstrate great uncertainty in the stratospheric response to climate change, with a significant spread among the models, even in the sign of the response. Uncertainty also exists in the tropospheric response to climate change, with a considerable spread in climate model predictions in terms of the jet position, particularly in winter, when the stratospheric influence is strongest. It remains unclear how the combination of the changes in both the stratosphere and troposphere may alter the downward impact of the stratosphere. I propose to address these questions through observational data analysis and a hierarchy of numerical models. I will use an idealized modelling framework, designed to capture major underlying processes of stratosphere-troposphere coupling, to isolate the dominant factors that control the downward impact of the stratosphere, and their response to climate change. The role of transient eddies in maintaining the downward response will be investigated. A comparison to more complex climate models will provide further insights into dynamical coupling. Better understanding the connection between the stratosphere and surface climate is essential for reducing the uncertainty in climate models and extreme events prediction.

Keywords: stratosphere troposphere coupling,storm tracks,idealized general circulation models
The first non-invasive device to detect kidney reflux in children (Kite)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2020)
Start date: 2020-09-01
End date: 2023-08-31
Duration (months): 36.0
Total project cost (EUR): 3164744.13
EU funding (EUR): 1795431.0
Participants: 1
Project status: CLOSED

The first non-invasive device to detect kidney reflux in children

Keywords: vesicoureteral reflux vur,reverse flow of urine from the bladder towards the kidneys,urinary tract infections
Getting ready to treat human patients with nanobody-targeted photodynamic therapy (READY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-01-01
End date: 2022-04-30
Duration (months): 28.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Unfortunately, current cancer therapies often fail to cure patients, or are associated with severe side effects. Ideally, a therapy should locally eradicate cancer cells without damaging healthy tissue and should induce long term protection through activation of the immune system. Photodynamic therapy (PDT) is a treatment approach which can do both, through the local light activation of photosensitizers. However, current photosensitizers lack cancer specificity, which limits therapeutic efficacy and prolongs photosensitivity in patients. Recently, Dr. Oliveira has developed an improved version of targeted PDT that uses small antibody fragments, i.e. nanobodies, to target the photosensitizer to cancer cells. Nanobodies distribute homogenously, bind rapidly and specifically to cancer cells, and are quickly eliminated when unbound. Within the ERC StG KILLCANCER project, the team has been focusing on better understanding the mechanism of nanobody-targeted PDT, its potential to induce tumor regression in vivo, and its capacity to trigger the immune system for long term protection. Results indicate this treatment could lead to improved selectivity and reduced side effects, compared to conventional PDT and antibody-targeted PDT. The fundamental objective of this ERC PoC is to ascertain the technical and commercial viability of nanobody-targeted PDT for treatment of head and neck cancer. Within this project, the aims are to: 1. Humanize the lead nanobody, validate the results, and explore GMP production 2. Perform an IP landscape analysis and establish freedom-to-operate (FTO) 3. Execute an extensive market, competitor, and stakeholder analysis, and 4. Develop a detailed business plan based on this information to accurately guide commercialisation. Together, these steps will be essential for nanobody-targeted PDT to be ready for the translation to humans, so that cancer patients and society as a whole can benefit from this promising alternative treatment.

Keywords: targeted therapy,nanobody,photodynamic therapy