Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Perspectival Realism. Science, Knowledge, and Truth from a Human Vantage Point (Perspectival Realism)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-01-01
End date: 2021-06-30
Duration (months): 66.0
Total project cost (EUR): 1606155.0
EU funding (EUR): 1606155.0
Participants: 1
Project status: CLOSED

This project develops a novel view in philosophy of science called perspectival realism, via a three-pronged highly interdisciplinary approach, which combines the philosophy of science, with scientific practice, the history of science and the history of philosophy. Scientific perspectivism has recently attracted a great deal of attention for its ability to account for the perspectival nature of modelling, pervasive in the physical sciences, the life sciences, and the social sciences. Can scientific knowledge be perspectival, and at the same time, true? Can perspectivism be made compatible with realism? Four goals guide and structure the project: (1) To offer a systematic investigation of how contemporary physicists deal with the perspectival nature of modelling, either by exploring innovative non-perspectival methods (in particle physics), or by devising ways of integrating different data sets and optmising their use for heuristic purposes (in observational cosmology). (2) To examine, via salient historical case studies, to what extent scientific controversies and disagreement among scientists can be traced back to perspectival modelling, including measurement and experimental techniques. (3) To re-assess the historical origins of perspectivism as a distinctive mode of scientific inquiry back to the Enlightenment, and in particular to Kant's 'Copernican Revolution'. (4) To critically elaborate a metaphysics for perspectival realism that can ultimately answer the overarching question: 'Can perspectivism be made compatible with realism'? The outcome is a scientifically and historically informed philosophical position, with the groundbreaking potential of advancing traditional debates about pluralism, unification, and realism in scientific research. The project pursues these goals via an innovative methodology, in five sub-projects, bringing together physicists, historians of science and of philosophy, and philosophers of science, in an unprecedented way.

Keywords: philosophy of science
Safeguarding Cultural Heritage through Technical and Organisational Resources Management (STORM)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Italy,Austria,Italy,Türkiye,Greece,Greece,Greece,United Kingdom,United Kingdom,Portugal,Portugal,United Kingdom,United Kingdom
Call: Disaster Resilience & Climate Change topic 3: Mitigating the impacts of climate change and natural hazards on cultural heritage sites, structures and artefacts (H2020-DRS-2015, 2015)
Start date: 2016-06-01
End date: 2019-05-31
Duration (months): 36.0
Total project cost (EUR): 7297875.0
EU funding (EUR): 7297875.0
Participants: 21
Project status: CLOSED

Starting from previous research experiences and tangible outcomes, STORM proposes a set of novel predictive models and improved non-invasive and non-destructive methods of survey and diagnosis, for effective prediction of environmental changes and for revealing threats and conditions that could damage cultural heritage sites. Moreover, STORM will determine how different vulnerable materials, structures and buildings are affected by different extreme weather events together with risks associated to climatic conditions or natural hazards, offering improved, effective adaptation and mitigation strategies, systems and technologies. An integrated system featuring novel sensors (intra fluorescent and wireless acoustic sensors), legacy systems, state of the art platforms (including LiDAR and UAVs), as well as crowdsourcing techniques will be implemented, offering applications and services over an open cloud infrastructure. An important result of STORM will be a cooperation platform for collaboratively collecting and enhancing knowledge, processes and methodologies on sustainable and effective safeguarding and management of European Cultural Heritage. The system will be capable of performing risk assessment on natural hazards taking into account environmental and anthropogenic risks, and of using Complex Events processing. Results will be tested in relevant case studies in five different countries: Italy, Greece, UK, Portugal and Turkey. The sites and consortium have been carefully selected so as to adequately represent the rich European Cultural Heritage, while associate partners that can assist with liaisons and links to other stakeholders and European sites are also included. The project will be carried out by a multidisciplinary team providing all competences needed to assure the implementation of a functional and effective solution to support all the actors involved in the management and preservation of Cultural Heritage sites.

Keywords: complex event processes,new policies and government processes,environmental,sensing and monitoring tools,hazard mitigation tools,situational awareness,collaboration and knowledge sharing services
Excellence in Smart Data and Services for Supporting Water Management (DATA4WATER)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Italy,Germany,Romania,Netherlands
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 999493.75
EU funding (EUR): 999493.75
Participants: 4
Project status: CLOSED

The objective is to enhance the S&T abilities in the field of smart, data driven e-services in water management, with focus on the widening organization. The complexity of research related to water management is extremely high and requires deep expertise in several ICT-related research domains. The dynamics of water and the role of humans in the water cycle are not well understood largely because environmental and socio-economic analyses are still performed separately. The specific objectives are: Enhance the science and technology capacity of the participating institutions; Raise staff’s research profile as well as the one of the institutions involved; Contribute to the Smart Specialisation Strategy; Contribute to the development of a new, interdisciplinary research domain. Main activities in the project are: organization of workshops, summer schools; exchange and training of researchers; develop a roadmap for the UPB, aligned with the partners’ research agendas in the area of IT for water management; development of a knowledge transfer and remote training system, and inclusion of UTB team in an operational research network. The research quality system will be set up, based on the Composite indicator of Research Excellence. The project will also help to raise staff’s research profile. The scientific strategy of the UPB team will be oriented towards inter/trans-disciplinary and practical applicability, valorization and impact in water management, which also fits to the Smart Specialization Strategy of Romania. The main expected impact is the increase of publications number with high visibility, and the creation of an active network with relevant stakeholders. The consortium was constituted so that it is representative for the research topic, that has a strong interdisciplinary character, with main focus on information technology. The project consortium consists of two leading research partners in the field of IT and a water management leading research partner.

Keywords: smart data,e services,water management,hydroinformatics
Two-dimensional quantum materials and devices for scalable integrated photonic circuits (2D-SIPC)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Tackling grand interdisciplinary science and technology challenges
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Netherlands,United Kingdom,United Kingdom
Call: FET Flagship on Quantum Technologies (H2020-FETFLAG-2018-03, 2018)
Start date: 2018-10-01
End date: 2022-03-31
Duration (months): 42.0
Total project cost (EUR): 2976812.5
EU funding (EUR): 2976812.5
Participants: 5
Project status: CLOSED

The proposed project aims at developing scalable quantum networks, based on photonic chip integration of novel 2D material quantum devices, with the main goal to demonstrate all-optical on-chip quantum processing. The recent demonstration of effortless integration of 2D materials onto photonics and CMOS platforms will result in a breakthrough in the development of on-chip quantum networks. 2D-SIPC will take full advantage of the huge variety of 2D materials and heterostructures and prototype novel quantum devices with revolutionary functionalities. In particular, we will develop electrically driven and entangled single photon emitters, broadband and high temperature single photon detectors, ultra-fast waveguide integrated optical modulators and non-linear gates. To pave the way to scalable networks, 2D-SIPC will develop large scale growth techniques of the most promising 2D materials. With this unique combination of features 2D-SIPC will allow the first demonstration of on-chip optical quantum processing, a key milestone for many quantum network concepts, such as extended secure quantum communication, scaling up of quantum computers and simulators, and novel quantum sensing applications with entangled photons. In particular, as these topics cover all four Quantum Technology pillars of the Quantum Flagship, our proposal makes a strong strategic link to each one of them. Beyond the 2D-SIPC platform, each developed component will be exploited in such distant fields as biological and medical imaging, radio-astronomy and environmental monitoring. The 2D-SIPC consortium includes four academic and one industrial partner with a high degree of complementarity that are at the forefronts of their fields, including single photon detection (ICFO), theory and fabrication of 2D materials and their heterostructures (UNIMAN), single photon emission (UCAM), chip based photonic circuits (CNIT) and commercial single photon detection, single photon emission and packaging (SQ).

Keywords: scalable photonics integration,single photon emitters,single photon detector,single photon nonlinearity,deterministic photonic quantum gates,scalable quantum information processing systems
Uncovering the role of the iRhom2-ADAM17 interaction in inflammatory signalling (iRhomADAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2023-04-01
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

The primary inflammatory cytokine, TNFalpha, is a transmembrane protein that requires cleavage by the metalloprotease ADAM17 for its release. Aberrant release of TNFalpha is a hallmark of cancer, chronic inflammation and autoimmune syndromes. The rising prevalence of these widespread diseases necessitates new approaches to manipulate inflammatory signalling, which is the overarching goal of this proposal. Recent studies demonstrate that iRhoms regulate trafficking, maturation and stability of ADAM17. Without iRhoms, TNFalpha shedding is abolished. The aim of this research is to dissect the transmembrane interaction between iRhom2 and ADAM17, which will support the required information to design the first iRhom inhibitor. Using FRET spectroscopy and ADAM17 activity assays, I will first search for essential residues at the transmembrane interface between iRhom2 and ADAM17. Next, I will use rationally designed helical peptides to competitively inhibit the transmembrane interaction. Last, I will test the effect of any inhibitors I develop in an in-vivo human macrophage model and use it to study the significance of this interaction. This study will provide an important mechanistic understanding of iRhom biology, with an emphasis on their mode of specific transmembrane recognition. Moreover, by developing the first specific iRhom2-ADAM17 complex inhibitor, I will establish iRhom2 and ADAM17 as therapeutically relevant targets to manipulate inflammation.

Keywords: rhomboids,pseudoenzymes,irhom,adam17,tace,tnfalpha,membrane proteins,protein protein interactions
Rapid tree-planting through the use of remote sensing and unmanned vehicle planting technologies for large scale reforestation (BioCarbon)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: United Kingdom
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Currently used methods for reforestation and tree-planting such as hand planting and direct seeding are time-consuming and expensive. As a result tree-planting has been unable to keep up with number of trees lost each year. Right now we are facing a net global loss of 6.6 billion trees each year. The EU is currently seeking out solutions to facilitate the sustainable supply of materials for the future and BioCarbon Engineering have developed a planting system to enable industrial scale reforestation protecting and regenerating forest resources. The planting system developed by BioCarbon Engineering consists of a mapping unmanned aerial vehicle (UAV), a planting UAV and machine learning software. It is a massive improvement on current reforesting techniques being a fully automated process and it will simultaneously enable cheaper and faster tree planting (10 seeds planted per UAV per minute). Given that the planting is being carried out by an aerial vehicle, it is possible to plant in terrain that is inaccessible by land-based approaches. It therefore offers a higher return on investment since it can carry out the same activity at a lower cost while also having a greater reach for tree planting. The Phase 1 project will be focused on establishing a complete supply chain, a sound business model and commercialization strategy, a planning of all activities for deploying a large scale pilot with the automated planting solution being demonstrated out in different ecosystems throughout Europe, as well as the elaboration of an industrialization and marketing plan.

Keywords: reforestation,sustainable resource supply,biodiversity,big data,drone
Activation Mechanism of a Glutamate Receptor (gluactive)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2020-12-31
Duration (months): 66.0
Total project cost (EUR): 1981500.0
EU funding (EUR): 1981500.0
Participants: 1
Project status: CLOSED

Glutamate receptors are amongst the most important signalling molecules in the brain. Activation of receptors by the neurotransmitter glutamate is required for nervous system function, underlying cognition, learning, memory and sensation. Despite advances in the study of their structural biology and physiology, how glutamate receptor complexes are activated remains unclear. With this proposal, we aim to determine how receptor activation and desensitisation are driven by glutamate binding. Our central approach is to map the motions of glutamate receptors during synaptic-like activity, in order to grab the frames needed to produce the movie of receptor activation. We aim to detect motion within the receptor on the angstrom scale by trapping conformational states during activation with artificial metal ion binding sites and disulfide bonds. Trapped receptors will be examined using biochemical measures of subunit association, biophysical reports of receptor activity and by structural biology. The results we obtain will be useful to rationally interfere with excitatory synapses in the brain and may therefore help the development of therapies.

Keywords: synaptic transmission,single channel recording
Accelerating drug and biomarker discovery through a new proteomic service: DrugPhosphoProfiler (DrugPhosphoProfiler)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2019-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

At present there is a huge interest in the pharmaceutical industry to find and develop new drugs targeting protein phosphorylation and their related biological pathways, due to the critical implication of these processes in many pathologies. The high complexity of these phosphorylation-dependent cellular signalling network makes very difficult to have a clear idea about the mechanism of action of a particular drug as well as its side effects. Unfortunately, existing approaches are unable to provide comprehensive, robust and quantitative data of cellular phosphorylation needed to support faster and more efficient drug discovery and development. Consequently, there is a large and unmet need in the pharmaceutical industry for identifying related therapeutic, toxicity targets and biomarkers, in order to develop better drugs. We are developing DrugPhosphoProfiler, an innovative mass spectrometry (MS)-based high-throughput platform for systematically measuring the effects of pharmaceutical agents on phosphorylation-dependent cellular networks in a proteome-wide and drug concentration-resolved manner. DrugPhosphoProfiler will be a unique, high-content drug discovery and development tool capable of providing essential and quantitative molecular pharmacodynamic data based on 25,000 phosphorylation sites in a single assay. The information obtained by our solution will go far beyond existing antibody-based detection systems and overcome their limits in terms of specificity and comprehensiveness without compromising sensitivity and robustness. DrugPhosphoProfiler will thus increase the success rate of pre-clinical drug discovery as well as clinical trials and eventually lead to more effective treatment of disease. Through this project (estimated ROI of 6), we at OmicScouts (SME, Germany) aim to boost the competitiveness of our company, by generating €8.6M revenues and increasing our team to 27 people (from 12), just 5 years after commercialization.

Keywords: pre clinical new drug discovery,protein phosphorylation,cellular signalling network,mass spectroscopy based phosphoproteomics,high throughput proteomic assay
Fashioning Georgian Englishness: Race, National Identity, and Codes of Proper Behaviour (FaGEng)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The proposed research project ‘Fashioning Georgian Englishness: Race, National Identity, and Codes of Proper Behaviour’ examines the interconnectedness of nationality, race, and conduct within an eighteenth-century colonial perspective. The interdisciplinary project argues that race played a vital but ambiguous role in the construction of the nascent English national identity in the Georgian era (1714–1830); however, since race was a fluid and heterogeneous concept, the racial and/or national status of English subjects was constructed through the vocabulary and practices of decency, propriety, refinement, and good conduct. Articulations and practices of class- and gender-based ‘proper behaviour’ were thus used to create a naturalised English national character that had a racial foundation. The project employs an interdisciplinary methodology that combines cultural and intellectual historical methods with constructionist and postcolonial perspectives; through this approach, it examines race and national character as deeply performative, fictive constructions, created through internalising discursive knowledge. The project makes a significant and novel contribution to the history of eighteenth-century English nationalism, which has thus far ignored the importance of race for the construction of a national identity. Moreover, the questions and themes the research addresses also offer a highly fruitful point of comparison to recent processes of cultural interaction and exchange, and the structures of racism and nationalism in present-day Europe.

Keywords: eighteenth century britain,identity,nationality,ethnicity,race,intersectionalism,performativity