Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dynamical river NETworks: climatic controls and biogeochemical function (DyNET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-05-01
End date: 2025-04-30
Duration (months): 84.0
Total project cost (EUR): 1999758.0
EU funding (EUR): 1999758.0
Participants: 1
Project status: SIGNED

Despite the ubiquity of expansion and retraction dynamics of flowing streams, the large majority of biogeochemical and hydrological studies conceive river networks as static elements of the landscape, and a coherent framework to quantify nature and extent of drainage network dynamics is lacking. The implications of this phenomenon extend far beyond hydrology and involve key ecological and biogeochemical function of riparian corridors. The proposed research project will move beyond the traditional paradigm of static river networks by unravelling, for the first time, physical causes and biogeochemical consequences of stream dynamics. In particular, the project will undertake the following overarching scientific questions: 1) what are the climatic and geomorphic controls on the expansion/contraction of river networks? 2) what is the length of temporary streams and what is their impact on catchment-scale biogeochemical processes and stream water quality across scales? These challenging issues will be addressed by developing a novel theoretical framework complemented by extensive field observations within four representative sites along a climatic gradient in the EU. Field measurements will include long-term weekly mapping of the active drainage network and daily hydro-chemical data across scales. The experimental dataset will be used to develop and inform a set of innovative modelling tools, including an analytical framework for the description of spatially explicit hydrologic dynamics driven by stochastic rainfall and a modular hydro-chemical model based on the concept of water age, able to account for the variable connectivity among soil, groundwater and channels as induced by stream network dynamics. The project will open new avenues to quantify freshwater carbon emissions - crucially dependent on the extent of ephemeral streams - and it will provide a robust basis to identify temporary rivers and maintain their biogeochemical function in times of global change.

Keywords: river networks,catchments,transport processes,modeling
The innovation journey of tourism entrepreneurs: evidence from the UK and Spain and policy implications (INNOVATE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This study seeks to bridge the conceptualization of innovation and entrepreneurship, analyse the entrepreneurial practices leading to tourism innovation in two different countries, and contribute to the design of more effective policies to enhance innovation practices across the EU. Specifically the study will address three main objectives which will be achieved using a mixed method research, involving both qualitative and quantitative approaches. First, to understand the innovation journey initiated by entrepreneurs in tourism, analysing the process and how these differ in the contrasting economic, tourism and institutional environments of Spain and the UK. This involves mainly a qualitative approach and the narratives of innovative entrepreneurs will be gathered through in-depth semi-structure interviews. Secondary data analysis and a first period of secondments with policy partners dealing with tourism and innovation will contribute to set the specific contexts influencing the innovation process in each country. Second, to analyse the development and performance patterns of a sample of young innovative entrepreneurs in tourism through a longitudinal study in Spain, specifically focussing on the determinants of innovation success or failure. Building on an initial previous contact, this will be accomplished through follow up interviews. And third, to inform policy guidelines and business practices through co-production of applied knowledge and guidelines with entrepreneurs and policy partner organizations in the UK and Spain. Key policy aspects identified during the previous stage will be transformed in collaboration with the policy partner organisations in an online survey targeting entrepreneurs to create validated policy guidelines. In summary, this contribution which aims to bring more coherence and effectiveness to tourism innovation policy-practice, is highly policy relevant for European competitiveness as innovation is the principal means of enhancing this.

Keywords: innovation,entrepreneurship,tourism,innovation process,innovation policy,recommendations
Cajal-Retzius cells role in the development of the spatial navigation system (CaRe-Space)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 214158.72
EU funding (EUR): 214158.72
Participants: 1
Project status: CLOSED

Cajal-Retzius (CR) cells play a pivotal role in the development of cortical areas, by guiding the migration of principal cells. While cortical CR cells disappear soon after birth, these cells are present in the hippocampus for several months of postnatal development. However, the role that CR cells play in hippocampus-dependent memories is still unknown. In fact, the hippocampal-parahippocampal region forms a network responsible for spatial representation, in rodents and in humans. In both species, spatial navigation shows a delayed postnatal maturation, which correlates with the persistence of CR cells. CR cells are indeed located in a key position to control the development of the entorhinal-hippocampal connections, and I have previously showed that CR cells are an active part of the hippocampal circuit. I hypothesize that hippocampal CR cells play a fundamental role in the maturation of the circuits of the hippocampal region and in the development of the spatial navigation system. By using specific genetic and molecular tools, I will ablate hippocampal CR cells at early postnatal stages and then analyze alterations of the circuit of the hippocampal region and of the spatial navigation system. The last decade has seen a major global effort in trying to understand how the brain processes information. Indeed, several research groups are investigating how spatial maps are created in the brain. However, few studies have looked at how the involved circuits actually develop and what are the consequences of an improper maturation. My previous research experience on the development of neuronal circuits and specifically on CR cells will benefit me tremendously in understanding how these cells are contributing to the creation of spatial memory. The study will also help bridging a gap between developmental and system neuroscience, a goal that I will keep pursuing in my future scientific career.

Keywords: cajal retzius cells,hippocampus,place cells,development
Quadratic refinements in algebraic geometry (QUADAG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-09-01
End date: 2025-02-28
Duration (months): 66.0
Total project cost (EUR): 2124663.0
EU funding (EUR): 2124663.0
Participants: 1
Project status: SIGNED

Enumerative geometry, the mathematics of counting numbers of solutions to geometric problems, and its modern descendents, Gromov-Witten theory, Donaldson-Thomas theory, quantum cohomology and many other related fields, analyze geometric problems by computing numerical invariants, such as intersection numbers or degrees of characteristic classes. This essentially algebraic approach has been successful mainly in the study of problems over the complex numbers and other algebraically closed fields. There has been progress in attacking enumerative problems over the real numbers; the methods are mainly non-algebraic. Arithmetic content underlying the numerical invariants is hidden when analyzed by these non-algebraic methods. Recent work by the PI and others has opened the door to a new, purely algebraic approach to enumerative geometry that recovers results in both the complex and real cases in one package and reveals this arithmetic content over arbitrary fields. Building on these new developments, the goals of this proposal are, firstly, to use motivic homotopy theory, algebraic geometry and symplectic geometry to develop new purely algebraic methods for handling enumerative problems over an arbitrary field, secondly, to apply these methods to central enumerative problems, recovering and unifying known results over both C and R and thirdly, to use this new approach to reveal the hidden arithmetic nature of enumerative problems. In 2009 R. Pandharipande and I applied algebraic cobordism to prove the degree zero MNOP conjecture in Donaldson-Thomas theory. More recently, I have developed several aspects of the theory of quadratic invariants using motivic homotopy theory.

Keywords: enumerative geometry,quadratic forms,motivic homotopy theory,gromov witten theory,hermitian k theory,chow witt groups
Power line vegetation monitoring and maintenance optimization with satellite imagery (PLMSAT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Portugal
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-11-01
End date: 2020-03-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Tesselo is a European start-up founded in 2017. Our core business is to leverage space data and Artificial Intelligence to map natural risks and ensure compliance to environmental regulation. We are now ready to apply our core-business technology to an innovative solution likely to disrupt power grid monitoring & insurance market: power lines monitoring using low cost-low resolution space imagery and deep learning AI models. This solution was awarded a seal of excellence (13,39/15) in SME Instrument evaluation in June 2019,we have refined it ever since. Since 2017, we have worked with the Portuguese association of Pulp and Paper producers and received 3 grants from the European Space Agency to develop our technology. We have built a solid expertise in the timber sector powered by state-of-the-art AI/deep learning techniques with paying customers. We now want to apply this knowledge to solve a global challenge: prevent natural risk around power lines. Electricity companies have to manage huge power lines grids exposed to severe vegetation-related risk. They have to comply to stringent regulation regarding distance to vegetation and obstacles, which obliges them to closely monitor networks. Today, monitoring relies on aerial hi-res imagery and human inspections and represents huge expenses. Our solution: map all grid with low cost low resolution (10 m) and flag risky areas where and when high resolution and trimming are necessary. We dramatically optimize data acquisition and operation planning, ensure legal environmental compliance and help save money. To deliver our services, we analyze satellite imagery with AI models and environmental science. Our main differentiating factor: our cutting-edge technology. Tesselo has designed a proprietary business-ready platform, able to automatically ingest, clean and analyze satellite imagery with AI, at any scale. Our team gathers all the skills to perform core business activities.
Colorectal Cancer Mouse Tumor Organoids as Pre-clinical Models for Therapeutical Testing (CRC-MTOs)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-12-01
End date: 2020-05-31
Duration (months): 18.0
Total project cost (EUR): 149955.0
EU funding (EUR): 149955.0
Participants: 1
Project status: CLOSED

Colorectal cancer (CRC) is one of the leading causes of death by cancer, which is largely associated to metastatic spread of the disease. Progress to develop efficient therapies, including immunotherapies, for patients with metastatic CRC has been hampered by the lack of preclinical models to study late stage CRC in an immunocompetent background. We have developed the first genetic mouse model of advanced CRC in immunocompetent mice. This model is based in a biobank of mouse tumor organoids (MTOs) derived from tumors arising in compound mice bearing genetic alterations in 4 driver genes associated to CRC progression: WNT, EGFR, p53, and TGF-beta signaling. We have demonstrated that these MTOs represent an invaluable tool for basic and pre-clinical research in CRC, in particular to test immunotherapies (Tauriello et al., Nature 2018). Despite its potential, the MTO biobank has limitations for translational research. They were generated as academic tools which has prevented their use in technology transfer projects and collaborations with pharmaceutical companies. In addition, they do not cover all the different CRC subtypes. We propose to create an improved and more complete second-generation MTO biobank that a) recreates the described pre-clinical model of advanced CRC, b) extends the model collection to other subsets of CRCs by means of genome editing tools and c) grants freedom to operate. These newly generated MTOs will represent unique tools ready to be licenced and exploited in strategic public-private collaborations with the final goal to aid in the development of new drugs to treat advanced CRC patients.

Keywords: mouse tumor organoids,pre clinical model,therapeutic testing,immunotherapies,licensing
Boosting plant-Endophyte STability, compatibility and Performance Across ScaleS (BestPass)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria,Spain,Austria,Germany,Spain,Austria,Germany,Germany,Poland,New Zealand,Netherlands,Netherlands,Denmark,Denmark,Denmark
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2015-09-01
End date: 2019-11-30
Duration (months): 51.0
Total project cost (EUR): 3907754.64
EU funding (EUR): 3907754.64
Participants: 17
Project status: CLOSED

We need to increase the crop yield while reducing pesticide and use of inorganic fertiliser to meet the challenges of world population growth and climate change. Plant endophytic microorganisms can improve plant yield and enhance plant tolerance to abiotic stress as well as to pathogens under experimental conditions, but these effects are often not sufficiently stable for practical application. How do we boost the stability and reliability of the positive effects of endophytes on plants? We need to understand the genetic basis of beneficial interactions between crops and endophytes and extent this basis exhibits phenotypic plasticity at all interaction levels from the cellular to the field environment. This requires increasing our knowledge of the molecular mechanisms underlying the effects of endophytes, including intra and inter-kingdom exchange and distribution of resources (nutrients), signalling and possibly regulation between and inside the partners, the mutual induced production of secondary metabolites and the environmental cues which influence crop-endophyte interactions. The genetic variation and its plasticity in host and microbe will be exploited in to establish crop breeding and inoculum production processes for boosting the establishment and stability of plant-microbe mutualisms to benefit crop development, stress tolerance, pathogen resistance and quality. In this project we will provide fundamental biological as well as practical knowledge about interactions between endophytes and plants. This improved understanding will pave the way for increased use of endophytes to improve sustainability and plant productivity in a reliable way. The participants in this project comprise many of the key institutions and industries working with these problems and provide a uniquely strong consortium to address the key issues. Furthermore, the consortium will train a new generation of scientists who have the insight and skills to continue this task in their careers.

Keywords: endophytes,microbial consortia,plant hormones,abiotic stress,plant diseases,seed coating,effector molecules,genetic diversity omics,inoculum production,fungi,bacteria
combining SYnthetic Biology and chemistry to create novel CO2-fixing enzymes, ORGanelles and ORGanisms (SYBORG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-12-31
Duration (months): 68.0
Total project cost (EUR): 1746038.0
EU funding (EUR): 1746038.0
Participants: 1
Project status: CLOSED

Carbon dioxide (CO2) is a potent greenhouse gas whose presence in the atmosphere is a critical factor for global warming. At the same time atmospheric CO2 is a cheap and readily available carbon source that can in principle be used for the synthesis of biomass/biofuels and value-added products. However, as synthetic chemistry lacks suitable catalysts to functionalize the CO2-molecule, there is an increasing need to exploit the CO2-fixing mechanisms offered by Nature for applications at the interface of chemistry and biology. This proposal is centered on reductive carboxylation, a completely novel principle of enzymatic CO2-fixation that we discovered only recently and that is one of the most efficient CO2-fixation reactions described in biology so far. First, we will focus on understanding the novel principle of reductive carboxylation, by studying its catalysis at molecular scale and single step resolution. This will allow us to derive the first detailed catalytic framework for highly efficient CO2-fixation and enable us to engineer novel carboxylation reactions and products. Second, we will establish a new in vitro platform for the assembly and optimization of artificial ("synthetic") CO2-fixation pathways that are based on reductive carboxylation and that have been calculated to be kinetically and bioenergetically favored compared with naturally existing CO2-fixation pathways. This platform closes a long-standing gap between the theory and practice of synthetic pathway design, and will be used to develop the first functional in vitro module for CO2-fixation, a "synthetic organelle". Finally, we will realize synthetic CO2-fixation in selected biological model systems. To that end, we will implement the optimized in vitro pathways in isolated chloroplasts, as well as alpha-proteobacterial hosts to create novel CO2-fixing organelles and organisms, breaking new grounds in understanding and engineering biological systems for efficient CO2-fixation.

Keywords: chemical biology,co2 fixation,carboxylases,enzymes,enzymology,cell free systems
SweNet Innovation Specialist and Key Account Manager Service (Swennis)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Sweden,Sweden,Sweden
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-07-01
End date: 2014-12-31
Duration (months): 6.0
Total project cost (EUR): 139562.5
EU funding (EUR): 111650.0
Participants: 4
Project status: CLOSED

The Swedish consortium working with Enterprise Europe Network will deliver services within the action ”Establishing services enhancing the innovation management capacity of SME’ in the Enterprise Europe Network” during 2014 and onwards. This proposal only covers services to be delivered during 2014 even though services to involved SMEs will proceed in 2015 to 2020. The project will involve six partners where The Swedish Agency for Economic and Regional Growth will be the coordinator. Swerea, Acreo and Centek will be the partners delivering services, both as Key Account Manager and as Innovation Specialists. Partners ALMI Mitt, SIK and Uminova will be involved in a reference group together with the NCP for SMEs. This application consists of four work packages: WP0 Integrate the KAM and EEN Innovation specialist services with the national supporting system for innovation and H2020 WP1 Provide Key account management (KAM) services for the beneficiaries of the SME Instrument WP2 Provide Innovation specialist services for selected SMEs to enhance their innovation management capacity. WP3 Manage the WP processes, tool development and training In total there will be six employees from Swerea, Acreo and Centek that will be delivering the services in WP 1 and 2 during 2014. The estimated number of SMEs participating in 2014 are 50 were 10 is coming from the SME Instrument and 40 will be selected for innovation management services. The selection will be made by a reference group in consensus to ensure that selected companies have a high growth potential. We will take into account both branch experience and geographic closeness to be able to signpost clients to the most appropriate partner. The tool to be used for enhancing innovation management capacity will be IMP3rove. The tool to be used by the staff working as KAM will be decided upon before the start of the action. All staff involved will be trained in using the tools before start.

Keywords: innovation,key account manager,innovation specialist,enterprise europe network