Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Storming Immune Monogenic Conditions through Multiomic and Gene Editing Approaches (IMMERGE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Germany,Italy,Switzerland,United Kingdom,Sweden,Israel,France
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 2921433.94
EU funding (EUR): 2591071.2
Participants: 27
Project status: SIGNED

The human immune system controls the efficiency to respond to infections and eliminate aberrant cells, such as cancer cells. Immune function depends on the balanced contribution of many genes, encoding for receptors, cytokines, cell signalling molecules and transcription factors and are modulated by a wide range of environmental and epigenetic factors. Monogenic mutations for immune-related genes, also known as Inborn Errors of Immunity (IEI), provide unique examples for understanding immune fitness. IEI, individually considered as rare diseases, constitute a group of >400 immune disorders with a combined prevalence similar to leukemias (1/1,000-1/5,000). For a given mutated gene, IEI patients can display a wide range of phenotypic expressivity (from asymptomatic to severely impaired) and different responses to treatments. Therefore, there is an unmet need to address the wide underlying impact of IEI. Previous EU consortia have not addressed these questions in full. It is therefore needed a new generation of researchers, equipped with a complete set of scientific, technological and strategic skills; and a wide vision to face the outstanding challenges in the IEI field. To this end, the IMMERGE MSCA DN combines the talent of leaders from different clinical and basic research and biotech environments to train 11 doctoral candidates. Through our research activity and training activities, we will address key challenges in the field: 1) To assess the functional impact of IEI in different immune cell types through single cell and bulk multiomics. 2) To develop computational tools for dissecting the altered cellular pathways underlying specific IEI. 3) To genetically correct or model IEI and develop pre-clinical models. With our strategy, IMMERGE will generate an outstanding network of professionals able to develop impactful studies that will change the field, generate tools for personalised medicine and generate awareness in the society and influence policy makers.

Keywords: inborn errors of immunity primary immunodeficiencies omics epigenetics single cell technologies bioinformatics immunology crispr and gene editing biomarkers
Flexible rhythm production abilities and cortical tracking of speech in the healthy and damaged brain (FlexyRhythm)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-05
End date: 2027-11-04
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 2
Project status: SIGNED

FlexyRhythm aims to move beyond traditional assessments of rhythmic abilities in the speech domain by proposing the strong hypothesis that synchronizing to isochronous speech is necessary but not sufficient for developing language abilities. In addition to this, the ability to flexibly reproduce and synchronize to slightly irregular rhythms typical of natural speech is crucial for enhancing the brain’s capacity to track continuous speech in naturalistic contexts. The project will develop a novel test to assess these abilities and investigate the relationship between flexible rhythm production abilities and key aspects of the human speaking brain, including: (i) statistical learning as a proxy for language acquisition, (ii) native language processing, (iii) second language learning, and (iv) speech-motor and language deficits following stroke. By employing magnetoencephalography (MEG) and state-of-the-art analytical tools such as temporal response function, coherence, and transfer entropy, the project will objectively assess the human brain's capacity to track and encode acoustic and linguistic information during speech listening (cortical tracking of speech), the neural auditory-motor connectivity dynamics underlying tracking, and the relation with flexible rhythm production abilities. FlexyRhythm offers a comprehensive exploration of the interplay between rhythm and speech, advancing our understanding in both healthy and damaged brains, across native and second language learning. The findings will provide scientific insights and societal benefits, including improved language teaching methodologies and personalized healthcare strategies for acquired speech and language disorders.

Keywords: rhythm production,synchronization,meg,cortical tracking of speech,statistical learning,speech motor and language impairments,stroke
Flexibility for Hydrogen (FLEX4H2)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Italy,Switzerland,Germany,France,Belgium,Norway
Call: Dry Low NOx combustion of hydrogen-enriched fuels at high-pressure conditions for gas turbine applications (HORIZON-JTI-CLEANH2-2022-1, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 4872197.5
EU funding (EUR): 4178517.25
Participants: 9
Project status: SIGNED

The project aims at moving technological frontiers for low-emission combustion of hydrogen to fuel modern gas turbines at high firing temperatures and pressures, beyond the latest state-of-the-art. This will be achieved whilst maintaining high engine performance, efficiency, fuel and load flexibility, without diluents. At the same time, all emission targets set by the Clean Hydrogen JU Strategic Research and Innovation Agenda (SRIA) will be met. The idea is based on a proprietary combustion technology, designated constant pressure sequential combustion (CPSC) already deployed into the GT36 H-class engine (760 MW in combined cycle). The CPSC concept, based on a unique longitudinally staged combustion system, yields the best fuel flexibility and has the greatest potential to achieve the project target of demonstrating stable and clean combustor operation with concentrations of hydrogen admixed with natural gas, up to 100%, at firing temperatures typical of modern H-Class engines. The new, improved combustor design will be fully retrofittable to existing gas turbines, thereby providing opportunities for refurbishing existing assets. The primary objective is to demonstrate the CPSC technology in engine relevant environment (TRL6) in three steps (70, 90 and 100 vol% H2). In this pursuit, a subset of specific performance data (KPIs) will be met within the project timeline and with the planned resources and allocated budget. The project uses state-of-the-art computational tools, analytical modelling, and diagnostic techniques to investigate static and dynamic flame stabilisation. Testing is performed at world-class laboratories in test campaigns at reduced scale and in full size (at atmospheric and pressurised conditions). In preparation for commercialisation, the project will also develop a roadmap towards deployment of the developed system into operation and demonstration into a power plant environment quantifying the valuable contributions to the EU Green Deal.

Keywords: dle hydrogen combustion technology,sequential combustion,fuel flexibility,decarbonisation,low emission,retrofittable design,load levelling,responsive power on demand,h class gas turbine
Hydrogen Aircraft Sloshing Tank Advancement (HASTA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Italy,South Africa,United Kingdom,Romania,France,Belgium
Call: Accelerating climate-neutral hydrogen-powered/electrified aviation (HORIZON-CL5-2023-D5-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 3294823.75
EU funding (EUR): 3294823.75
Participants: 16
Project status: SIGNED

Environmental concerns motivate a transition to liquid hydrogen aviation fuel in coming decades, and for this technology the size, placement and connections of the hydrogen tank on an aircraft are key decisions. The Hydrogen Aircraft Sloshing Tank Advancement project (HASTA) aims to experimentally and computationally investigate the storage of liquid hydrogen (LH2) for airborne use as fuel in civil aircraft applications. Size and position of a LH2 tank inside an aircraft are limiting factors for range, payload and aircraft size, and consequently play a crucial role in the environmental impact. The goal of facilitating tank design will be achieved through creation of design criteria for LH2 aircraft tanks; these design guidelines will be based on the different tools and models of derived during the project, in particular those aimed at complex cryogenic sloshing. The experimentally validated design tools developed during HASTA are to be used for both conceptual and detailed design in the aircraft industry, and therefore span a range of fidelities from reduced order models to full computational methods. The primary focus of this project will be the development of LH2 capabilities, and particularly the extension of mature capabilities already available for sloshing of standard civil aircraft fuel (kerosene) to the cryogenic temperatures associated with LH2. These capabilities are well reflected in the composition of the consortium, which includes partners with both experimental and modelling experience of fuel slosh, as well as cryogenics for space applications. The ultimate goal of the project is development of experimentally validated numerical and analytical simulation tools to model the complex thermo-fluid-dynamics of cryogenic LH2 coupled to the thermo–mechanical behavior of a tank and its operational environment.

Keywords: transport,sloshing,liquid hydrogen,fuel tank,liquid hydrogen tank,ullage pressure reduction,thermal effects,hydrogen fuel,co2 reduction,clean aviation,pumping system,combustion chamber
ASSESS-DHT: DEVELOPMENT AND HARMONISATION OF METHODOLOGIES FOR ASSESSING DIGITAL HEALTH TECHNOLOGIES IN EUROPE (ASSESS-DHT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Maintaining an innovative, sustainable and globally competitive health industry
Action type: Research and Innovation actions
Countries involved: Germany,Belgium,Spain,Italy,United Kingdom,Austria,Sweden,France
Call: Development and harmonisation of methodologies for assessing digital health technologies in Europe (HORIZON-HLTH-2023-IND-06, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 6422635.0
EU funding (EUR): 6422635.0
Participants: 16
Project status: SIGNED

ASSESS-DHT will increase the adoption of trustworthy and effective Digital Health Technologies (DHT) across Europe, enabling a more coherent digital single market, for health systems and patients to access DHT from all over Europe and giving industry a European market. We will develop a new assessment framework, beyond the existing models, capable of uniform HTA adoption across Europe, addressing new assessment challenges in Digital Therapeutics, AI and telehealth. Our consortium comprises 4 HTA bodies, the European Observatory on Health Systems and Policies, 5 academic and not for profit organisations with expertise in EU Regulation, DHT development and assessment methodologies, data protection, data quality, interoperability and cybersecurity. Patients and health professionals are included through the International Diabetes Federation and European Society of Cardiology. We include the DHT industry through companies with products for us to assess through a formal methodology mimicking actual HTA assessments – 3 as partners, some through an open call and industry-wide consultation via DIGITAL EUROPE. We will engage healthcare payers and ministries through our Advisory Board. We will co-create our overarching assessment framework with specialised pathways for different categories of DHT specified through a novel evidence-based typology. We will cater for phased adoption (going beyond fast track models like DiGA), complex life-cycles, iteratively developed AI, consolidated in a comprehensive HTA assessment manual plus specific guides in topics like cybersecurity. We will develop a sustainable repository containing the ASSESS-DHT framework, pathways and unambiguous criteria, a semantically searchable evidence library, checklists and tools to support companies with evidence generation, evidence of health system value from DHT, and online communities of practice.

Keywords: digital health technology assessment
HOmogenous heating of Thermal FlUids based on Metamaterials (HOTFUM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-16
End date: 2028-01-15
Duration (months): 30.0
Total project cost (EUR): 262393.2
EU funding (EUR): 262393.2
Participants: 3
Project status: SIGNED

HOTFUM aims to demonstrate the feasibility of developing an innovative Power-to-Heat & Thermal Energy Storage (P2H & TES) interconnected technology. The main idea is that a novel power-to-heat approach can induce uniform heating in heat transfer fluids (HTFs), which are used for both heat transfer and TES. Electricity can be converted into heat using technologies like resistive heating, which directly heats HTFs. This method can lead to uneven temperature distribution, causing hot spots that may damage the HTF and reduce the lifespan of the heating elements. Both P2H & TES systems, face similar challenges due to non-uniform heating of HTFs. HOTFUM offers a novel approach by exploring the use of nanoparticles (NPs) suspended in different HTFs like water, synthetic oils, ionic liquids, and molten salts. The objective is to demonstrate a novel power-to-heat approach for heating these fluids. HOTFUM is strategically designed to take advantage of the researcher´s expertise in nanofluids for TES systems, the advanced characterization techniques available at CIIAE, the strong background of the supervisor in the field of TES. The project includes a secondment in a group specialized in nanotechnology and a placement in a SME focused in the development of NPs.

Keywords: nanomagnetism,magnetism and strongly correlated systems,new materials oxides,alloys,composite,organic inorganic hybrid,nanoparticles,renewable energy sources
Uniform inference with time series (Persistence)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2025-09-01
End date: 2029-08-31
Duration (months): 48.0
Total project cost (EUR): 664850.0
EU funding (EUR): 664850.0
Participants: 2
Project status: SIGNED

This project proposes a novel econometric approach suited for hypothesis testing and confidence interval construction in the presence of generic time series regressors with arbitrary persistence degree. The project will develop inference for a large class of regressor processes commonly encountered in macroeconomic and financial data, ranging from stationary, local-to-unit-root, explosive, long memory, time-varying parameter and other nonstationary processes as well as multivariate systems containing mixed components. The key idea behind the approach is to build a new explanatory variable from the data which conforms to a standard central limit theory even when the original regressor does not. The resulting instrumental variable estimators based on this endogenously constructed instrument are shown to be asymptotically mixed-Gaussian regardless of the true stochastic nature of the regressor, implying standard inference for any IV-based self-normalised test. The main contribution of the project is to place a large class of nonstandard processes with a wide range of dynamics and memory properties under a common econometric framework which delivers standard inference regardless of the regressor's stochastic properties. The asymptotic development of the procedure requires fundamental theoretical contributions such as a novel Granger-Johansen type representation theory for multivariate time series with mixed stochastic components and the asymptotic analysis of time series with different persistence types. The novel procedure is shown to be valid uniformly across persistence regimes and automatically delivers asymptotically correct inference without a priori knowledge of the regressor's true stochastic nature. In addition to its generality and theoretical coherence, the approach has the added advantage of ease of implementation (with closed-form estimators and tests that employ standard critical values), thus making it suitable for general practical application.

Keywords: time series,uniform inference,confidence intervals,central limit theory,autoregression,predictive regression,instrumentation,mixed gaussianity,t statistic
Iraqi Cinema Beyond the Screen (ICBS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-25
End date: 2026-01-24
Duration (months): 39.0
Total project cost (EUR): 226751.04
EU funding (EUR): 226751.04
Participants: 1
Project status: SIGNED

In the beginning of the 20th century, Iraqi cities and urban environments changed and new public spheres and forms of work and leisure emerged. New neighborhoods, and institutions, cafés, and theaters changed the structure of urban life. In the process, modern leisure and entertainment began moving from the private realm into the public and increasingly came to be organized on a commercial scale. One index of these changes was cinema, which arrived in Iraq in the early 20th century and quickly became a highly popular form of entertainment. A modern and global rather than a specifically Iraqi development, the emergence of cinema in Iraq can be seen as a local inflexion of a global phenomenon. Situated at the crossroads of Egyptian, Indian, European, and American film production, cinema in Iraqi sheds light on the transnational qualities of early cinema in Iraq itself but also in the many areas across the globe where national cinema only emerged belatedly. Yet, the development of the specific culture of cinema, so significant in the history of Iraq as well as in the field of cinema studies and nonwestern cinema, has received scarce attention. My project undertakes this fresh subject, interrogating the transnational circulation of cultural products and material objects, including films and technology, and exploring how they came together at a particular historical moment with capital, performers, and people with technical skills to establish cinema as a form of leisure in Iraq. Studying the emergence of cinema in Iraq through an approach that attends to cinema’s material and transnational histories and contexts can enhance our understanding not just of Iraq and its many entangled networks, connections and histories, but also of early cinema outside of the global centers of gravity. Finally, TECI shows how the intersection of capital, public space, and popular entertainment lays open both the possibilities, tensions, and conflicts that developed in 20th century Iraq.

Keywords: iraq,baghdad,middle east history,history of leisure
Optoelectronic and all-optical hyperspin machines for large-scale computing (HYPERSPIM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Italy
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2490000.0
EU funding (EUR): 2490000.0
Participants: 1
Project status: SIGNED

Efficient hardware for combinatorial optimization and machine learning impacts science, engineering, and society. With new computational models, photonics tackle problems intractable with conventional computing systems. However, existing devices only scale up to thousands of spins and operate at the second timescale. I demonstrate photonic machines for ultrafast parallel processing of millions of spins with microsecond timescale. The strategy is minimizing a class of functions, the Ising Hamiltonian, by a new computational system that uses a high-dimensional feature space and speeds up optimization by orders of magnitude by ultrafast nonlinear optical processes. I build digital, optoelectronics, and all-optical classical and quantum devices and benchmark with real-world, large-scale problems. By spatial modulation technology and a cheap, simple, and scalable design, light propagation is recurrently trained towards the ground state of a programmable Ising Hamiltonian. Starting from my proof-of-concept, first, I aim at the energetically efficient computing of large-scale Hamiltonians. Second, I include self-optimizing all-optical nonlinear ultrafast phase-locking processes. Third, I demonstrate record combinatorial optimization by letting the spins evolve in a high dimensional space to guarantee high success probability. HYPERSPIM leverages the interplay of classical and quantum dynamics through the onset of entanglement and squeezing. The unprecedented scale and versatility allow the first quantum optimization tests for real-world complex computational tasks. HYPERSPIM achieves the fastest and biggest optical computing device operating in classical and quantum regimes in an interdisciplinary route towards new photonic artificial intelligence, large-scale all-optical computing, and fundamental science.