Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
NeoCel – Novel processes for sustainable cellulose-based materials (NeoCel)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Research and Innovation actions
Partnership: BBI (Art-187)
Countries involved: Germany,Switzerland,Türkiye,Finland,Sweden,Sweden,Sweden,Switzerland,Romania
Call: Sustainable cellulose-based materials (H2020-BBI-PPP-2015-2-1, 2015)
Start date: 2016-09-01
End date: 2019-12-31
Duration (months): 40.0
Total project cost (EUR): 3569716.75
EU funding (EUR): 1934233.25
Participants: 16
Project status: CLOSED

The main objective of NeoCel project is to develop innovative and techno-economically feasible alkaline processes enabling the sustainable production of higher quality eco-innovative textile fibres from reactive high-cellulose pulps and integration of these processes with pulp mills. Targets for the development of NeoCel processes are: - wet strength of fibres higher than the wet strength of standard viscose, competing with cotton properties. - lower environmental impact than any other type of existing textile fibre - Reduction of production cost by at least 15% compared to that of best available technology (BAT) viscose The targets will be met through development of adapted pulps with high reactivity/solubility in alkaline water-based solutions, advanced dissolution process to maximize cellulose concentration, novel cellulose regeneration chemistry enabling both recovery of process chemicals and increased strength properties of the spun fibre, design for integration of textile fibre production with the pulp mill for minimized environmental impact, increased energy efficiency and reduced chemical consumption through system analysis using software models of theoretical mills. In NeoCel, a consortium with raw material processing companies, chemical suppliers, equipment producers, SMEs and world-leading research institutes has formed to develop the processes for large scale manufacturing of eco-innovative textile fibres. The consortium expects that a successful NeoCel project will enable creation of 75 000 new jobs and a turn-over increase of 9.5 billion € for European forest products, textile and clothing industries within 15 years. However, already within 3 years, the consortium partners expect their joint turnover to increase by 170 MEuro

Keywords: man made cellulosic fibres,textile recycling,pulp mill integration,sustainable textile production,energy and cost optimisation,chemical recovery,large scale manufacturing,european production
Advancing Science and TEchnology thRough dIamond Quantum Sensing (ASTERIQS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Tackling grand interdisciplinary science and technology challenges
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Germany,Germany,Israel,Germany,Germany,Germany,Switzerland,Switzerland,Belgium,Hungary,Lithuania,France,France,France,France,United Kingdom
Call: FET Flagship on Quantum Technologies (H2020-FETFLAG-2018-03, 2018)
Start date: 2018-10-01
End date: 2022-03-31
Duration (months): 42.0
Total project cost (EUR): 9747888.75
EU funding (EUR): 9747888.5
Participants: 24
Project status: CLOSED

ASTERIQS will exploit quantum sensing based on the NV centre in ultrapure diamond to bring solutions to societal and economical needs for which no solution exists yet. Its objectives are to develop: 1) Advanced applications based on magnetic field measurement: fully integrated scanning diamond magnetometer instrument for nanometer scale measurements, high dynamics range magnetic field sensor to control advanced batteries used in electrical car industry, lab-on-Chip Nuclear Magnetic Resonance (NMR) detector for early diagnosis of disease, magnetic field imaging camera for biology or robotics, instantaneous spectrum analyser for wireless communications management; 2) New sensing applications to sense temperature within a cell, to monitor new states of matter under high pressure, to sense electric field with ultimate sensitivity; 3) New measurement tools to elucidate the chemical structure of single molecules by NMR for pharmaceutical industry or the structure of spintronics devices at the nanoscale for new generation spin-based electronic devices. ASTERIQS will develop enabling tools to achieve these goals: highest grade diamond material with ultralow impurity level, advanced protocols to overcome residual noise in sensing schemes, optimized engineering for miniaturized and efficient devices. ASTERIQS will disseminate its results towards academia and industry and educate next generation physicists and engineers. It will contribute to the strategic objectives of the Quantum Flagship to expand European leadership in quantum technologies, deliver scientific breakthroughs, make available European technological platforms and develop synergetic collaborations with them, and finally kick-start a competitive European quantum industry. The ASTERIQS consortium federates world leading European academic and industrial partners to bring quantum sensing from the laboratory to applications for the benefit of European citizens.

Keywords: quantum sensing,nv centre,nitrogen vacancy,diamond,spin,colour centers,scanning tip,magnetic field
Moral & Intellectual Qualities of the Political Man in the Translations of Gracián's Work (XVII-XXI cent.) (VIR MAXIMUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-02
End date: 2021-09-01
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

VIR MAXIMUS is an innovative tool that helps trace the history of the ‘soft’ policy transfer in and outside Europe since 17th to the 21st centuries. It is based on the suggestion that the flow of ideas across borders and in time can be unveiled with the help of the sufficiently vast collections of translations of the same text. Such corpora will allow to intercept not only the transmission, adaptation and transformation of moral-political concepts in different countries, but also their evolution over time within a single culture (in cases when multiple translations of a text to the same language carried out in different epochs are available). More than 150 translations of Baltasar Gracián’s writings to more than 30 languages, sometimes by eminent personalities such as A. Schopenhauer, offer an extraordinary example of such a collection, but its potential is still underestimated: in fact, the complete list of these texts is still lacking. VIR MAXIMUS will provide a complete annotated catalogue of translations of Gracián’s work and a concrete example of the use of these texts: the database of the moral-political lexicon in about 50 different translations (the main European languages are considered) that will help to detect the dynamics of the local reception of Gracián’s thought and the shifts in the history of moral-political concepts. The MSCA Fellowship will bring Riva Evstifeeva, Russian language professor in Italy who holds a MA in Medieval European History and a PhD in Comparative studies, to Sorbonne Université where she will work in the research team headed by Mercedes Blanco, the top-rank scholar in Spanish studies and the leading expert in Gracián’s work.

Keywords: spanish literature,translation studies,siglo de oro,savoir vivre treatises,linguistic databases
Imaging flow cytometry using holographic virtual staining (HoloStain)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Imaging flow cytometry (IFC) holds great promise as clinical screening and diagnostics platform, as it can capture, process and analyse a large number of cells in bodily fluids, useful for hematology and hemato-oncology. However, currently IFC captures cell morphology by imaging each fluorescently-stained cell organelle on a different region of the camera sensor, dictating complicated and expensive optics and processing units. Current IFC remains a highly inaccessible technology, due to its very high cost, lack of accuracy, required operator expertise, and lack of objectiveness. The global flow cytometry market is estimated as USD 3.29 Billion in 2017, and projected to reach USD 4.79 Billion by 2022. This rapid growth is due to anticipation of becoming more common in clinical use. In this project, we will develop and commercialize a novel IFC platform. Using an external portable interferometric module and novel analysis methods, we perform quantitative holographic virtual staining (HoloStain) of the multiple cell organelles, simultaneously on a single IFC channel, dramatically simplifying the optics, cameras, and processing. Preliminary results are provided. As HoloStain does not require cell staining for morphological evaluation, it is ideal for real-time sorting or subsequent cell use. Moreover, HoloStain provides multiple virtually stained slices from the same camera frame, earning higher throughput. These unique advantages are expected to revolutionize the IFC market in two possible product-realization pathways: (i) as a more cost-effective stand-alone IFC workstation, and (ii) as an add-on module to an existing IFC workstation, upgrading its capabilities. Both pathways are highly attractive for licensing to existing flow cytometry manufacturers or for founding a startup company. In this project, upon completing marketing requirement and product characterizations, we will build an alpha prototype, and present it to potential strategic partners and investors.

Keywords: imaging cytometry,digital holographic microscopy,quantitative phase imaging
Modelling Neuron-Glia Networks into a drug discovery platform for Pain Efficacious Treatments - Sofia ref.: 116072 (NGN-PET)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Germany,Spain,Germany,Germany,Italy,United Kingdom
Call: PATHOLOGICAL NEURON-GLIA INTERACTIONS IN NEUROPATHIC PAIN (H2020-JTI-IMI2-2015-07-two-stage, 2015)
Start date: 2017-04-01
End date: 2020-03-31
Duration (months): 36.0
Total project cost (EUR): 3050000.0
EU funding (EUR): 1500000.0
Participants: 6
Project status: CLOSED

Chronic Neuropathic Pain is frequently associated with peripheral nerve injury or disease. Peripheral injury activates both neuronal and glial components of the peripheral and central cellular circuitry. While it is widely known that the subsequently altered interactions between neurons and glial cells contribute to pain development and to its chronification, the underlying mechanisms are poorly understood. Developing mechanism-based therapies targeting neuron-glial interactions to treat chronic pain will be crucial for improving the quality of life of many patients. Hence the development of novel therapeutic solutions represents a major challenge that demands a multi-disciplinary approach to decipher and understand pathological mechanisms and to translate them into predictive tools for drug development. The NGN-PET consortium addresses this challenge by forming a highly interdisciplinary team that builds upon expertise in areas of academic research on pain mechanisms, industrial knowhow on human stem cell-based tool development, HTS technologies and drug discovery. To achieve its goal we will develop preclinical model systems and assays which recapitulate the human in vivo situation and which can be interrogated for the identification, validation of molecular targets and the development new treatments. A focus of the project will be chemotherapy induced NP and the interplay between nociceptors, microglia and Schwann cells. NGN-PET will carefully characterize rodent in vivo and in vitro models to identify these mechanisms, and will develop rat and human iPSCs based in vitro systems of neuron-glial co-cultures that can be interrogated for targets and used for compound identification and validation. NGN-PET will thus pose the basis for the translation of these model systems into high throughput screening platforms for pharmaceutical research and drug discovery.

Keywords: neuron,glia,co culture,ipsc,hipsc,cell culture,pain,cell sorting,chemotherapy,microdialysis,proteomic,genomic,microfluidics,neuropathic disease model,nociceptors
Business Experiments in Cyber Physical Production Systems (BEinCPPS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Italy,Austria,Germany,Spain,Italy,Germany,Germany,Spain,Spain,Spain,Italy,Switzerland,Serbia,France,France,Portugal,Portugal
Call: ICT Innovation for Manufacturing SMEs (I4MS) (H2020-FoF-2015, 2015)
Start date: 2015-11-01
End date: 2018-10-31
Duration (months): 36.0
Total project cost (EUR): 9517642.5
EU funding (EUR): 7999485.75
Participants: 24
Project status: CLOSED

BEinCPPS Innovation Action aims to integrate and experiment a CPS-oriented Future Internet-based machine-factory-cloud service platform firstly intensively in five selected Smart Specialization Strategy Vanguard regions (Lombardia in Italy, Euskadi in Spain, Baden Wuertemberg in Germany, Norte in Portugal, Rhone Alpes in France), afterwards extensively in all European regions, by involving local competence centers and manufacturing SMEs. The final aim of this Innovation Action is to dramatically improve the adoption of CPPSs all over Europe by means of the creation, nurturing and flourishing of CPS-driven regional innovation ecosystems, made of competence centers, manufacturing enterprises and IT SMEs. The BE in CPPS project stems upon three distinct pillars: • A FI-based three-layered (machine-factory-cloud) open source platforms federation, integrated from state-of-the-art R&I advances in the fields of Internet of Things, Future Internet and CPS / Smart Systems and able to bi-directionally interoperate data pertaining to the machine, the factory and the cloud levels. • A pan-European SME-oriented experimentation ecosystem. In a first phase of the project, the five Champions will provide requirements to the platforms integrators. In a second phase, an Open Call for IT SMEs developers (applications experiments) will award 10 third parties. In a final third phase, the extended platform will be instantiated and deployed in additional 10 third parties equipment experiment SMEs. • A well-founded method and toolbox for Innovation management, where an existing TRL-based methodology for KETs technology transfer will be enriched by a CPPS certification, education and training programme for young talents and experienced blue collar workers and by a well-founded three-fold (objectives-variables-indicators) method for results assessment and evaluation.

Keywords: cyber physical production systems,smart specialisation strategy,federated platform by iot fi smartsystems,open call for applications equipment experiments
Neutrophil subtypes: distinct cellular targets for therapeutic intervention (TANTUMorNEUVACCINE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2020-09-30
Duration (months): 36.0
Total project cost (EUR): 265840.2
EU funding (EUR): 265840.2
Participants: 2
Project status: CLOSED

In cancer immunotherapy and vaccine field, considerable efforts have been invested to optimize the induction of effector T cells that, by recognizing tumor-specific or pathogen-associated antigens, control tumor cells or infections. Preserving effector T cell function is a major focus of cancer immunotherapy approaches for clinical trials, as is the development of strategies to target regulatory T cells (Tregs) that directly control T cell hypo-responsiveness. In the vaccine field, on the other hand, several strategies have been developed to improve T cell immunogenicity to heterologous antigens expressed by viral vectors. Especially for HIV viral vectors, new vaccine approaches have yielded promising results in primates, although effectiveness was limited in human clinical trials so far. Tumor-associated neutrophils (TAN) participate in the control of human tumor progression. If and how TAN interact with effector Tregs at distinct tumor stages remains to be determined. TAN signals that may regulate the functional state of tumor T cells must be defined. It is also not known whether Tregs interact with TAN and facilitate their functional switch from anti- to pro- tumorigenic state. Distinct neutrophil subtypes are recruited as a result of pro-inflammatory environment during virus infection. Study of the mechanism of neutrophil-dependent control of T cell subset responses to virus-delivered antigens would be of major interest for the generation of viral-based vaccines. The ability of neutrophil subtypes to interact with T cells must be defined to improve the virus-based vaccine efficacy. Our studies could provide: • new treatment strategies that prevent TAN dysfunction, Tregs activation and subsequent effector T cell hyporesponsiveness, and thus increase the effectiveness of cancer immunotherapy • new vaccine approaches to modulate neutrophil subtypes responses to improve antigen-specific T cell responses, and thus increase the effectiveness of HIV vaccines.

Keywords: immunotherapy,neutrophils subtypes,tumor,regulatory t cells,cytotoxic t lymphocytes,multiphoton intravital microscopy,infection,vaccine,nfkb signaling,antigen presenting cells,vaccinia virus
Controlling epileptic brain networks with computationally optimized weak electric fields (GALVANI)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Spain,France,France,France
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-06-01
End date: 2026-05-31
Duration (months): 72.0
Total project cost (EUR): 9998177.0
EU funding (EUR): 9998177.0
Participants: 5
Project status: SIGNED

Epilepsy is a neurological disorder affecting 65 million people worldwide. Pharmacological treatments or surgery are ineffective in one third of the cases – 19 million people. Recent findings indicate that non-invasive brain transcranial current stimulation (tCS) is safe and of therapeutic promise in epilepsy. However, it is not yet indicated as a standard treatment due to major scientific limitations: unknown mechanisms of action, insufficient account for patient-specific factors, poor understanding of short- and long-term effects. Our ambition is to transform the care of a large fraction of patients living with drug-resistant epilepsies by solving a fundamental problem: to efficiently target and control large-scale epileptic brain networks with tCS-induced neuromodulatory weak electric fields. To proceed, GALVANI’s synergetic research strategy addresses four interdisciplinary challenges: (1) Unravel the intricate relationship between weak electric fields and their neurophysiological effects at the level of neurons, neuronal assemblies and networks; (2) Maximize their therapeutic effects by altering the neurodynamics of patient-specific epileptogenic networks; (3) Develop optimal personalized neuromodulation protocols for novel multichannel tCS technologies; (4) Test optimized protocols in a cohort of patients and objectively define potential responders. The required competences and resources are met in GALVANI, uniting the passion and background of three experts and their teams in biomathematics (computational neuroscience), biophysics (bioelectromagnetism) and medicine (epileptology). The project vision is that critical features of pathological networks can be effectively captured in a new generation of hybrid computational models developed for tailored therapy. The inflection point is to prevent epileptic seizures from a bottom-up mechanistic understanding and control of tCS effects. This will entail a paradigm shift in epileptic disorders and beyond.

Keywords: epilepsy,therapeutic neuromodulation,electric fields,bioelectromagnetism,neurophysiological,models,biophysical models,personalized models,signal processing,optimization,transcranial stimulation,clinical trial
Intergovernmental Organizations between Mission and Market: International Institutional Law and the Private Sector (PRIVIGO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Finland
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 2407105.0
EU funding (EUR): 2407105.0
Participants: 1
Project status: SIGNED

Intergovernmental organizations (IGOs) such as the World Health Organization or International Maritime Organization have always been assumed to work for the public good. Yet, they also engage the private sector in many ways. Some are funded by the private sector or set up public-private partnerships; IGOs themselves act and compete on markets when procuring goods and services or when marketing their own services; and their operations and standard-setting activities inevitably affect the distribution of benefits between private parties. Like most organizations, IGOs allocate costs and benefits, and therewith affect the private sector. IGOs are said to exercise functions on behalf of member states and for the public good, yet the encounter with the private sector may see them act in tension with this public mission. PRIVIGO will investigate this tension, first, by examining how widespread private sector involvement is and how IGO law responds to this involvement. Second, PRIVIGO will examine how the underlying framework of the law is affected: the legal rules are informed by theoretical considerations that are, in turn, informed by assumptions and axioms that are rarely questioned yet may be fundamentally irreconcilable with private sector involvement. In this manner, PRIVIGO will change how IGO law and IGO lawyers perceive and understand IGOs, renewing IGO legal theory. PRIVIGO will build on case studies conducted in eight different and varied domains where IGOs with a clear public mission are active and connections to the private sector are visible: food security; transportation; energy provision; health; human re-settlement; finance; resources and environment; and arms control. PRIVIGO aims to develop the law relating to IGOs and build up solid theoretical foundations, mindful of the huge impact of IGOs on our everyday lives.

Keywords: intergovernmental organizations law,international law,international organizations