Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
COMFUTURO iAGE: Addressing the Global Ageing Challenge through Excellent Research, Digitalisation and Innovative Solutions (COMFUTURO iAGE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain
Call: MSCA COFUND 2024 (HORIZON-MSCA-2024-COFUND-01, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1692000.0
EU funding (EUR): 1692000.0
Participants: 9
Project status: SIGNED

COMFUTURO iAGE is a 60-month programme designed to recruit ten top researchers (with up to 8 years of postdoctoral experience and who comply with the MSCA mobility rule) providing them with 36-month fellowships to conduct innovative projects at the Spanish National Research Council (CSIC), Spain’s leading public research institution. Coordinated by Fundación General CSIC (FGCSIC), with extensive experience in public-private research collaboration, it offers researchers an opportunity to engage in cutting-edge research addressing the broad challenge of ageing, with special emphasis on digitalisation, key priority for Europe’s future. Fellows, recruited through a transparent and international selection process, will have the freedom to choose their specific research topics within the scope of ageing and digital transformation, encouraging groundbreaking ideas that can contribute to scientific advancement but also have the potential to impact society positively. COMFUTURO iAGE offers a research-related and transferable skills training programme to prepare fellows for future challenges. A series of associated partners will contribute to this training and will provide fellows with career development opportunities. Furthermore, the fellowship will include a non-academic secondment, which will allow fellows to immerse themselves in diverse environments, enriching their perspectives and significantly enhancing their career perspectives and employability, both within and outside academia. Recruited fellows will receive guidance from qualified supervisors and support from various CSIC and FGCSIC offices, including the Welcoming International Talent (WIT) office at CSIC or departments with specialized expertise in open science, gender diversity, or IPR. COMFUTURO iAGE, with a strong interdisciplinary, intersectoral, and international dimension, aims to provide a dynamic environment that can foster fellows' proffesional growth and advancements in ageing and digitalisation.

Keywords: interdisciplinary research,cross sector collaboration,global partnerships,ageing solutions,digital innovation,sustainable development,professional growth,societal impact,advanced technology
Preclinical in vitro Models for the Replacement, Reduction and Refinement of Mouse Models in Preclinical Studies (PRIM-TECH3R) (PRIM-TECH3R)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Technology and infrastructures
Action type: Research and Innovation actions
Countries involved: Austria,Italy,France,United Kingdom,Netherlands,Finland,Denmark,Czechia,Germany,Greece
Call: R&D for the next generation of scientific instrumentation, tools, methods, solutions for RI upgrade (HORIZON-INFRA-2024-TECH-01, 2024)
Start date: 2025-04-01
End date: 2028-03-31
Duration (months): 36.0
Total project cost (EUR): 8999960.0
EU funding (EUR): 8999960.0
Participants: 19
Project status: SIGNED

The use of mouse models in biomedical research has been pivotal in understanding human diseases due to their genetic and physiological similarities to humans. However, concerns on ethics and translatability have prompted a shift towards alternative methods such as complex in vitro models (CIVMs). PRIM-TECH3R addresses this shift by leveraging advanced technologies to develop reliable mouse and human CIVMs for preclinical studies, aiming to reduce and refine the use of animal models. Through standardised protocols and robust validation procedures, the project will create state-of-the-art in vitro models from mouse disease models, complementing existing in vivo models. This initiative aligns with EU policy objectives and societal demands to address phasing out of animal testing in biomedical research. The project will establish a comprehensive repository of preclinical resources, ensure open access, and foster collaboration between research infrastructures and the biomedical industry. Training programmes will equip personnel with the necessary skills to provide CIVMs to the research community. By achieving these objectives, PRIM-TECH3R aims to advance the state-of-the-art in research infrastructures, facilitate industrial exploitation, and contribute to transformative changes in biomedical research practices.

Keywords: civm,disease models,mouse models,3r,animal welfare,biobanking,training
Molecular and genetic determinants of plant tolerance to viruses (TolGreen)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

Viral diseases cause severe damage to cultivated plants, resulting in global crop losses. In the wild, however, plants are typically free of viral disease symptoms despite recurrent infection. Naturally tolerant plants have a significant viral load, but their growth, development and reproduction are only minimally affected. The aim of the TolGreen project is to identify viral and host determinants of tolerance by using Arabidopsis-infecting RNA viruses such as Tobacco mosaic virus (TMV) and the related Oilseed rape mosaic virus (ORMV) as models. Certain natural accessions of A. thaliana (Col-0) are tolerant to TMV whereas other ecotypes (Sha) show disease. By contrast, Col-0 plants infected with ORMV are initially symptomatic but develop tolerance in the new leaves. The host laboratory demonstrated that this latter tolerance phenotype depends on genes required for the production of primary and secondary siRNAs and also correlates with the loss of the activity of the viral RNA silencing suppressor (VSR). The tobamoviral VSR proteins inhibit antiviral RNA silencing by sequestration of small interfering RNAs (siRNAs), which inhibits the assembly of the antiviral RNA-induced silencing complex (RISC). Therefore, tolerance may occur when the VSR siRNA binding activity is saturated by host- or virus-derived siRNAs. Using the latest tools of molecular genetics and proteomics, TolGreen will determine Arabidopsis genes, viral and host-derived siRNAs as well as VSR-interacting proteins that control VSR activity and are involved in tolerance. Understanding the molecular mechanism of tolerance will provide important tools for the breeding of resilient, virus-tolerant crops for a more sustainable agriculture.

Keywords: plant virus interactions,tolerance,recovery,rna silencing,viral suppressor of rna silencing,small rnas,arabidopsis
Human-Centric AI platform for heALth and Life sciences (HCAI4ALL)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Denmark,Spain
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 3564427.5
EU funding (EUR): 2495099.0
Participants: 2
Project status: CLOSED

Abzu ApS – an EU-based deep-tech start-up – is redefining the AI landscape with an explainable, accurate and scalable solution – the QLattice – poised to disrupt the global AI race as the first truly responsible, trustworthy and transparent AI. With EIC support and based on 15+ pharma pilots with second to none explainable and accurate insights, Abzu will develop Reason – a tailor-made platform for pharma readily utilized by non-code savvy R&D scientists. Current black box solutions lack user-friendliness and have failed to restrain steady R&D costs increases in the last 15 years (~€2.5B per drug today). Reason will reverse this trend with added value in key metrics of increased ROI, productivity, and treatment availability. Abzu’s business, technology and the EU’s strategic goals are at a unique crossroads of technological, societal and economic disruption. EIC funds will make Abzu the next EU unicorn and result in the EU disrupting and gaining a foothold in the global AI market.

Keywords: drugs,visualization and natural language processing,human computer interaction and interface,,data protection and privacy,information science and bioinformatics,computer sciences,algorithms and complexity,advanced computing,big data,pharmaceutical randd,life sciences randd,machine learning
Levitated Quantum Engine (Lev-Q-Engine)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: CLOSED

To meet the global demand for sustainable energy, new forms of clean energy sources based on heat to work conversion need to be developed. To that end, the emerging field of quantum thermodynamics aims at devising nanoscale heat engines to exploit quantum resources and represents a promising vector to industrialize quantum technologies. However, it is still a great challenge to design and control nanoscale heat engines in the quantum regime. The proposed project employs the optomechanical platform of levitated nanoparticles to harvest thermal fluctuations in the regime where quantum effects are relevant. In particular, it will elucidate the role of inertia in thermodynamic heat engine cycles, exploit bath engineering techniques and explore the emergence of a quantum speed limit. The project combines the exquisite optomechanical control of levitated nanoparticles for fast potential change and cooling methods with optimal control theory including shortcut-to-adiabaticity techniques. The project benefits from the experienced researcher (ER) extensive skills in stochastic thermodynamics, optomechanics and quantum optics, the supervisor track record in nano-optics, optical tweezers and stochastic thermodynamics, and the theoretical support with experts in optimal control theory, both in the classical and quantum regimes. The project will therefore offer a critically required insight towards future commercialization of more efficient, less power-consuming quantum machines.

Keywords: stochastic thermodynamics,engines,optical tweezers,quantum thermodynamics,out of equilibrium processes
Decode and Cure primary Focal Segmental Glomerulosclerosis (CureFSGS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Kidney diseases are a worldwide rising major health problem associated with an excess risk for cardiovascular disease and reduced life expectancy. While general risk factors for kidney diseases such as diabetes and hypertension are being addressed through numerous research efforts, causes of specific glomerular kidney diseases, especially Focal Segmental Glomerulosclerosis (FSGS), remain poorly understood. FSGS is the most common glomerular cause of end stage renal disease characterized by scaring of the glomerular kidney filters and podocytes loss. Until now, the development of specific therapies has been hindered by the poor stratification of FSGS entities and the lack of understanding of immune mediated forms of FSGS. CureFSGS will establish a new strategy to identify key factors in FSGS: First, CureFSGS will develop a molecular classification of FSGS entities by utilizing a worldwide unique kidney sample repository/ registry combined with a novel analysis pipeline of single cell analytics, multiplex imaging and machine learning-aided image analysis to guide clinical decision making and to provide novel molecular insights. Second, CureFSGS will precisely decode immune mediators of FSGS and systematically map the podocyte response towards immune actions by devising a novel complementary platform of immune cell analytics and podocyte in vitro, ex vivo perfused kidney, in vivo as well as human organoid systems. Third, CureFSGS will ultimately precision target the identified immune cells, soluble immune factors or podocyte injury pathways by newly developed cell-specific AAV- and nanobody strategies. Together, CureFSGS will set the stage to finally understand and treat FSGS effectively.

Keywords: translational medicine,nephrology,kidney physiology
Engineered carrier transport in nanostructured semiconductors using functional disorder. (EnVision)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 1995625.0
EU funding (EUR): 1995625.0
Participants: 1
Project status: SIGNED

Disorder is generally considered to have a purely negative impact on carrier transport and most efforts aim to minimize it. However, recent studies suggest that disorder may enhance carrier transport via carrier funneling along energetic gradients or promote carrier interconversion at defect sites. Critically though, before disorder can be exploited for improved optoelectronic performance of nanomaterials, a better understanding of the relationship between disorder and transport is needed. EnVision aims to build a bridge between fundamental observations of the benefits of disorder and materials engineering. To enable this, I have designed a two-fold strategy focussed on 1) defining the detailed design rules for the rational design of disorder driven carrier transport and interconversion, and 2) develop strategies to engineer the local energy landscapes of nanostructured semiconductors that boost carrier transport and interconversion. To enable the definition of the detailed design rules, I will take the crucial step of developing Hyperspectral Transient Microscopy – the first super-resolution technique capable of simultaneously visualizing the transport of carriers in space, time, and energy. Using metal-halide perovskites as a versatile testbed, EnVision will make critical advances beyond the current state-of-the-art in promoting carrier transport along compositional gradients, boost carrier interconversion at local dopants site, and the creation of on-demand energy landscapes using nanoindentation. Through its unique approach, EnVision will introduce the concept of functional disorder, paving the way for new formalisms nanomaterial engineering and guiding the realization of fully optimized energy landscapes for optoelectronic and photonic technologies.

Keywords: semiconductor nanomaterials,carrier transport,disorder,microscopy,spectroscopy
EPIGENETIC-GENETIC-MENTAL HEALTH CASCADE BASED PERSONALISED PREVENTION OF NON-COMMUNICABLE DISEASE IN ADOLESCENTS DIAGNOSED WITH AUTISM (ETHEREAL) (ETHEREAL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Italy,Ireland,Romania,United Kingdom
Call: Non-communicable diseases risk reduction in adolescence and youth (Global Alliance for Chronic Diseases - GACD) (HORIZON-HLTH-2022-DISEASE-07, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 1780806.74
EU funding (EUR): 1780806.74
Participants: 7
Project status: SIGNED

Five Noncommunicable Diseases (NCD) – diabetes, cardiovascular disease, cancer, chronic respiratory disease and Mental Health Disorders (MHD) – account for 86% deaths and 77% disease burden in the WHO Europe region. Of these five NCDs, MHD is unique as it has a complex bi-directional relationship with the other four major NCDs, meaning that, on one hand, it could be the initiator of the other NCDs, or other NCDs could lead to MHD which, in turn, can further aggravate the primary NCD leading to a vicious circle. Recent research identified MHD as the highest ranked NCD in adolescent population. A specific group in this population that is 3 - 6 times more vulnerable for developing MHD and subsequent NCD is the adolescents diagnosed with Autism Spectrum Disorders (ASD). There is no Evidence Based Intervention (EBI) for preventing MHD in an ASD adolescent since 1) the major risk factors are in-grained in their biological process and 2) they present with multiple MHD comorbidity. Personalisation is the key to prevent their already vulnerable mental states making transition to an MHD - "which" EBI is appropriate for "which" ASD adolescent and "how" to choose it - an unsolved question. Because of their neurobiological characteristics, personalisation must be done at biological level. Recent research showed how the environmental factors can alter gene expressions that leads to an MHD through Epigenetic-Genetic/metabolomic-Mental health (EGM) process. Using quantitative modelling of this process, ETHREAL will develop a personalised, flexible, single service delivery model that will empower an ASD adolescent to self-control their environmental factors while seamlessly accessing the community care services to prevent their mental health making transition to an MHD - a unique solution for sustainable prevention of MHD and subsequent NCDs in this population. Without loss of generality, the proposed solution could be adapted to prevent MHD in wider adolescent population.

Keywords: autism spectrum disorders,mental health,noncommunicable diseases
Development of an Orexin 1 Receptor Antagonist for Binge Eating and other behavioural disorders (ORIND)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 18.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Theracryf plc are developing a highly selective orexin 1 receptor (Ox1R) antagonist to treat binge eating and other addictive disorders. This project will focus on late preclinical work to complete the IND/CTA package supporting progression into the clinic.

Keywords: preclinical ind toxicology manufacturing safety pharmacology addiction therapeutic cns
Interface-sensitive Spectroscopy of Atomically-defined Solid/Liquid Interfaces Under Operating Conditions (Interfaces at Work)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-05-01
End date: 2027-04-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Charge-transfer reactions are key not only to the way that nature fuels life in photosynthesis but also in synthesizing sustainable fuels like hydrogen. Charge transfer occurs at interfaces with an applied potential, yet almost all our understanding of electrocatalytic activity trends comes from the bulk material properties in the as-prepared state. We still lack interface-sensitive spectroscopy tools that can probe the composition and electronic structure under reaction conditions. Only with such interface-sensitive operando information can we fully understand the underlying reaction mechanisms and devise strategies for efficient energy conversion and storage. In Interfaces at Work, I will overcome these limitations by developing novel interface-sensitive operando X-ray spectroscopies combined with model electrochemical surfaces with atomic-layer compositional control, merging the fields of surface science and liquid electrochemistry. My aim is to fully visualize the physico-chemical properties of the solid/liquid interface under operating conditions. Specifically, I will develop a new laboratory-based, multicolour operando “meniscus XPS” (X-ray photoelectron spectroscopy) and transform the recently invented “membrane XPS” by making it accessible to the relevant electrochemical materials using these materials themselves as new membranes. I will apply these novel techniques to electrocatalyst and pseudocapacitor model systems based on epitaxial oxide thin films and 2D carbides. Ultimately, the proposed approach will allow me to track the surface and subsurface properties under applied potential to shed light on the electrochemical mechanisms. The operando insights will result in design rules for efficient energy conversion and storage on the chemical and electronic properties of a true electrochemically active surface under operating conditions rather than the as-prepared bulk. This will help our transition towards sustainability.

Keywords: operando spectroscopy,photoelectron spectroscopy,water electrolysis,electrocatalysis,pseudocapacitor,oxide epitaxy,mxene