Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PERSONALISED RECOVERY THROUGH A MULTI-USER ENVIRONMENT: VIRTUAL REALITY FOR REHABILITATION (PRIME-VR2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Ireland,Ireland,Italy,Malta,Cyprus,Finland,Hungary,Greece,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Interactive Technologies (H2020-ICT-2018-3, 2018)
Start date: 2019-10-01
End date: 2022-12-31
Duration (months): 39.0
Total project cost (EUR): 3998353.75
EU funding (EUR): 3998353.75
Participants: 15
Project status: CLOSED

Virtual Reality (VR) environments have huge potential for those with compromised physical capability in providing a sense of freedom and motivation, but there are significant barriers in access and effective use in this context. To address these user and technological challenges, this project aims to develop an accessible, collaborative VR rehabilitation environment that uses a serious gaming virtual space to provide stimulus, socialisation and friendly competition for users on the path to rehabilitation. By focussing on upper mobility and the reclamation of fine motor skills, the issues of fidelity of movement, ergonomic accessibility, adaptive testing and feedback, and socicalision become paramount in creating a viable user experience. Access to the VR environment will be via customised, adaptive controllers that are tailored for individual users to provide a unique and enhanced level of accessibility and constructed using advanced additive manufacturing techniques. The delivery of the software and hardware elements of this research will require the development of an integrated digital platform that will extend state-of-the-art digital technology in: the configuration of a collaborative VR serious gaming environment for rehabilitation purposes; the rapid acquisition of detailed anatomical and biomechanical user data in relation to the upper body with a focus on the hands and wrists; new principles of mechanical switch actuation and form generation in additive material structures; advanced human-centred design techniques to determine requirements and assess performance; and extended principles of design for manufacture and automation for additive structures and housing design. Three demonstrator controllers will illustrate how arm, hand and finger movements can be remapped for dynamic travel according to specific user conditions and allow for validation of a sustainable competitive ecosystem of European technology in the domain of interactive rehabilitation.

Keywords: virtual reality,assistive controllers,rehabilitation,3d scanning,additive manufacture,human centred design
Unconventional Superconductivity at Microkelvin Temperatures (UCSMT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

A new frontier is the investigation of quantum materials under the extreme conditions of ultralow temperatures. Its exploration requires the refinement of existing high sensitivity, low dissipation measurement techniques, the development of new ones, and access to ultralow temperature platforms. Quantum materials host a variety of exotic quantum phases, arising from interactions and the effects of strong correlations. An important example is the emergent unconventional superconductivity in heavy fermion systems when tuned by some control parameter to a quantum critical point. This project combines my expertise with the expertise, facilities and instrumentation of the host group. I will investigate two important unconventional superconductors in this regime, YbRh2Si2 and Bismuth, using high quality single crystal samples. YbRh2Si2 is a prototype quantum critical, heavy fermion metal with a field-tuned quantum critical point. Magnetic measurements on high quality single crystal samples at the lowest fields find evidence for superconductivity. I will address the nature of this superconductivity, the role of quantum criticality, the interplay of electro-nuclear magnetism, and the use of strain as a tuning parameter in this system. This will be done through electrical and thermal transport measurements, investigating their crystalline anisotropy, as well as heat capacity studies. In each case I will exploit new methods tailored for this temperature regime. This work will be coupled with studies of the Meissner effect and anisotropy of the critical field. The recent discovery of superconductivity in Bismuth, a system with very low carrier density, below 0.53 mK has provoked significant theoretical interest in the pairing mechanism. The first transport measurements will be performed on this system. The project will advance the understanding of unconventional superconductivity, and contribute to the strategy to study quantum materials into the microkelvin regime.

Keywords: micro kelvin,dilution refrigerator,nuclear demagnetization,quantum critical points,single crystals
Reconstituting Autophagosome Biogenesis in vitro (Autophagy in vitro)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany,France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2021-01-31
Duration (months): 70.0
Total project cost (EUR): 1499726.0
EU funding (EUR): 1185057.5
Participants: 2
Project status: CLOSED

Autophagy is a catabolic pathway that delivers cytoplasmic material to lysosomes for degradation. Under vegetative conditions, the pathway serves as quality control system, specifically targeting damaged or superfluous organelles and protein-aggregates. Cytotoxic stresses and starvation, however, induces the formation of larger autophagosomes that capture cargo unselectively. Autophagosomes are being generated from a cup-shaped precursor membrane, the isolation membrane, which expands to engulf cytoplasmic components. Sealing of this structure gives rise to the double-membrane surrounded autophagosomes. Two interconnected ubiquitin (Ub)-like conjugation systems coordinate the expansion of autophagosomes by conjugating the autophagy related (Atg)-protein Atg8 to the isolation membrane. In an effort to unravel the function of Atg8, we reconstituted the system on model membranes in vitro and found that Atg8 forms together with the Atg12–Atg5-Atg16 complex a membrane scaffold which is required for productive autophagy in yeast. Humans possess seven Atg8-homologs and two mutually exclusive Atg16-variants. Here, we propose to investigate the function of the human Ub-like conjugation system using a fully reconstituted in vitro system. The spatiotemporal organization of recombinant fluorescent-labeled proteins with synthetic model membranes will be investigated using confocal and TIRF-microscopy. Structural information will be obtained by atomic force and electron microscopy. Mechanistic insights, obtained from the in vitro work, will be tested in vivo in cultured human cells. We belief that revealing 1) the function of the human Ub-like conjugation system in autophagy, 2) the functional differences of Atg8-homologs and the two Atg16-variants Atg16L1 and TECPR1 and 3) how Atg16L1 coordinates non-canonical autophagy will provide essential insights into the pathophysiology of cancer, neurodegenerative, and autoimmune diseases.

Keywords: autophagy,in vitro reconstitution,model membranes
Demonstrators for Conversion, Reactor, Radiator And Thrusters for Electric Propulsion Systems (DEMOCRITOS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European research in support of international space partnerships
Action type: Coordination and support actions
Countries involved: Italy,Germany,Russian Federation,France,France,France,France,United Kingdom,United Kingdom
Call: Technology “demonstrator projects” for exploration (H2020-COMPET-2014, 2014)
Start date: 2015-03-01
End date: 2017-02-28
Duration (months): 24.0
Total project cost (EUR): 1010470.0
EU funding (EUR): 999969.75
Participants: 13
Project status: CLOSED

The objective of this proposal is to investigate the necessary demonstration activities in order to mature technologies for nuclear electric propulsion (NEP) systems that is considered one of the key enabler to allow deep exploration and science missions both manned and unmanned. The DEMOCRITOS projects aims to define three Demonstrator Concepts in regards to NEP technologies: 1. Detailed preliminary designs of ground experiments that will allow maturing the necessary technologies in the field of MW level nuclear electric propulsion. The project will investigate the interaction of the major subsystems (thermal, power management, propulsion, structures and conversion) with each other and a (simulated) nuclear core providing high power, in the order of several hundred kilowatts. 2. Nuclear reactor cost studies and simulations to provide feedback to the simulated nuclear core of DEMOCRITOS ground experiments as well as conceptualize the concept of nuclear space reactor and outline the specifications for a Core Demonstrator, including an analysis of the regulatory and safety framework that will be necessary for such a demonstration to take place on the ground. 3. System architecture and robotic studies that will investigate in detail the overall design of a high power nuclear spacecraft, together with a pragmatic strategy for assembly in orbit of such a large structure coupled with a nuclear reactor. Additionally, the project partners will define a programmatic plan, insuring that the demonstrators can be built, tested, and reach the established ambitious objectives, this with a clear organization between international partners and with costs shared in a sustainable way. DEMOCRITOS aims to form a cluster around NEP related technologies by organizing an international workshop and invite external stakeholders to propose ideas for the ground and flight demonstrators or possibly join in the effort to realize the ground demonstrator experiments.

Keywords: nuclear electric propulsion,high power systems,high power electric propulsion
Development of computational and experimental noise assessment and suppression methodologies for the next generation of silent distributed propulsion configurations (SilentProp)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Belgium,France,Czechia,United Kingdom,United Kingdom
Call: Experimental and numerical noise assessment of distributed propulsion configurations (H2020-CS2-CFP10-2019-01, 2019)
Start date: 2020-04-01
End date: 2023-09-30
Duration (months): 42.0
Total project cost (EUR): 2025046.25
EU funding (EUR): 2025046.25
Participants: 5
Project status: SIGNED

Distributed Electric Propulsion (DEP) is particularly attractive from a noise reduction perspective since the induced high frequency noise is associated with: i) increased atmospheric absorption benefiting citizens and ii) improved structural shielding benefiting passengers as well as citizens. SilentProp specific objectives are: -Performing an inclusive testing campaign within a modern and large anechoic wind tunnel configuration. Comprehensive measurements for a wide range of experimental and operational parameters will be delivered for quantifying interactions when adjacent propellers are operating within a DEP system. -Developing a seamless and efficient numerical methodology for providing near field and far field numerical noise computations for DEP configurations nominally identical to the ones experimentally tested. A reduced surrogate modelling approach will also be delivered for accelerating the subsequent optimization procedure. -Experimentally and numerically assessing the effectiveness of established, as well as novel noise suppression technologies including propeller phase blocking for directional sound cancellation and poroelastic, metamaterial and adaptive liners in a variety of configurations. Noise structural shielding by the aircraft structures will also be quantified to evaluate induced disturbance for citizens, as well as passengers. SilentProp will directly contribute to the CS2JU vision of drastically reducing aircraft induced community noise. This will be achieved by delivering key technological advancements to the European aerospace sector that will eventually facilitate the optimal multidisciplinary design and social acceptance for DEP configurations. The Consortium will advance the understanding of key noise aspects involved in DEP systems, enabling initial evaluation of the overall noise level produced for a wide range of DEP designs, as well as provide substantiated appraisal of the efficiency of several noise mitigation means.

Keywords: distributed electric propulsion,experimental noise measurement,numerical aeroacoustic noise prediction,noise suppression technologies,noise shielding
NATURHEALTH FOOD: NEW GENERATION OF NATURAL BIOPRESERVATIVE SUBSTITUTE OF CURRENT E-NUMBERS IN FOOD PRODUCTS (Naturhealth Food)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Biofactoría Naturae et Salus is a biotechnological company created in 2011 which extracts healthy ingredients and additives from fungi and vegetables in order to produce high value foodstuffs. The company has 12 employees and an operational manufacturing biofactory of cutting edge technology. One of the principal problems in food industry is food preservation. Most food products in the world add chemical preservatives into them (E-numbers). The presence of food preservatives of chemical origin, E-numbers, in food represents a worry for 66% of Europeans. There is international scientific research that concludes that chemical preservatives (E-numbers) can pose health-related problems and environmental problems. The objective of our project consists on industrially producing a worldwide novelty: a new and natural biopreservative, Naturhealth Food® able to substitute the chemical preservatives in food (E-numbers) in most foodstuffs with similar efficacy and a competitive price. This biopreservative will be harmless for people and environment. In Biofactoría Naturae et Salus S.A. we have achieved some milestones. Naturhealth Food® has already been successfully manufactured in our biofactory and tried in numerous foodstuffs without affecting their organoleptical properties. In order to prepare Phase 2 of this project, where the scaling-up of the process and the extension of our facilities will be carried out, we need to conduct a feasibility study of the project (Phase 1). This feasibility study will comprise four main activities: a technical study, a market analysis and customer discovery, an economic study and Intellectual property rights and legal issues. Our target market is the Food Industry in general. Given that this market is huge to begin with, Biofactoría Naturae et Salus proposes to focus on the high value foodstuffs market. Naturhealth Food® sales expectations will be of 35,000,000 € per year in 2022 with a net profit of 6,400,000€ during that year.

Keywords: feasibility analysis
Structured photonics for advanced fibre lasers (SPAFIL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-06
End date: 2017-07-05
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The key goals of the project are: (1) the training of a talented, independent researcher, Dr Amos Martinez, to become a successful leading scientist in the fast growing field of science, technology and industrial applications of fibre lasers, (2) exploring new ways to exploit two-dimensional materials, such as graphene, in photonics through femtosecond laser nanostructuring and developing new classes of light sources for applications in optical communications, medical imaging, industrial manufacturing and metrology. This multidisciplinary project has great implications on laser science, nanotechnology, material science and graphene technologies such as graphene plasmonics, metamaterials, phononics and electronics, and will involve both fundamental and applied research. The interdisciplinary training scheme is designed to enhance Amos’s expertise in photonics, strengthening his skills and helping him establish a research career in Europe. It covers component design and implementation, theoretical analysis, mathematical modelling and nanomaterial characterization. To assist Amos in reaching professional maturity and increase his exposure to academic and industrial collaborations, he will receive training on intellectual property management, funding and proposal writing, commercialization, business and finance management, and supervision and teaching. Secondments in academic and industrial co-hosts, with Prof. James R. Taylor (Imperial College, UK), Prof. Zhipei Sun (Aalto University, Finland), Xtera Communications (UK), Chromacity Lasers (UK) and Optoscribe (UK), are arranged to pursue scientific objectives, maximize Amos’s learning experience, expanding his network in Europe and maximising impact of research and training on EU industry. Exploiting his editorial experience at Nature, Amos will give seminars on effective scientific writing and engage with the public through outreach activities of the Physics Factory and the International Year of Light 2015.

Keywords: graphene photonics,fiber lasers,nanostructured graphene
STRANICH F3000: AN ENERGY EFFICENT INDUSTRIAL TURBOFAN FOR HIGH PRESSURE APPLICATIONS REQUIREMENTS (Stranich F3000)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Aeromecannica, is a well-stablished Italian SME company with 40 years’ experience in the design and fabrication of fans and blowers, with a strong presence at international level. In this Phase 1, we aim to determine the financial and technical viability of the industrialisation process of a low energy consumption turbofan for fluid concentrations with pressures over 15,000 Pa. Target sectors include the Food & Beverage, Chemical and Petrochemical Industries. We propose an innovative impeller design that allows the flow to go through the impeller free of turbulences, thus improving aerodynamic efficiency. The main advantage is the consistent reduction of the absorbed power resulting in an increase of energy up to 15% more than the existing competitors in the market for similar applications and a 33% saving on capital investment. Thanks to this new design, the European targeted industries will be able to commit with the regulatory framework and reduce the operation costs, making them more competitive face to international markets. We will not offer a single product to the market, but a range of products to satisfy the demands of different clients avoiding oversized products. With a scaled-up prototype already manufactured and tested, in Phase 2, will develop 3 serial products for different flow rates: <50,000 m3/h; 50,000 -100,000 m3/h and >100,000 m3/h and design the final automated manufacturing line. Within this Phase 1, Fully assess reliable cost forecast for the final automatic manufacturing line to be installed in Phase 3 and definition of the financial strategy implementations. We will also draft the principal lines of our commercialisation strategy to launch STRANICH F3000 to the Italian and European markets (from the Italian and French agencies). We expect a payback period of 3 years, a Return of Investment (ROI) of 2.31 in year 5, with a cumulated turnover of € 11,57 million in 2024.

Keywords: centrifugal fans,mechanical vapour compression,blowers,evaporation,liquid concentration,compressors,food processing equipment,fluid compression,chemical industry,petrochemical industry
Facile Oxygen Consumption Assay for Lacteal Industry and Spoilage Evaluation (FOCALISE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2018-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Nowadays, there is a big concern about food safety as unsafe food containing harmful bacteria, parasites, moulds and yeasts or chemical substances, causes more than 200 diseases, ranging from diarrhoea to cancers. World Health Organization estimated that 600 million worldwide, fall ill after eating contaminated food and water and 420,000 die every year, resulting in the loss of 33 million healthy life years. Diarrhoeal diseases are the most common illnesses resulting from the consumption of contaminated food, causing 550 million people to fall ill and 230,000 deaths every year. In addition, dairy products and specially milk can be contaminated with pathogen microorganism and produce customer disease. Monitoring the microorganism in dairy products would benefit public health, reducing foodborne diseases. The current technologies used for microbial detection are time-consuming (8 days) that generate an increase of the stock and storage cost and their manipulation is complex. In response, we at OXOBROBICS BIOSCIENCE have developed FOCALISE (facile oxygen consumption assay for lacteal industry and spoilage evaluation) microplates capable of performing a fast (2-3 h), high accurate, simple detection, non-cytotoxic, high sensitive and repeatability process of different type of microorganisms in dairy products and water. The FOCALISE multi well plates are preloaded with a fluorescent probe that is sensitive to the concentration of oxygen released to the medium by microorganisms allowing in a user-friendly and cost-effective manner the accurate detection of pathogens. Before the microplate achieves the market, we need to improve its development and do a business plan. Thus, in Phase 1 we aim to run a Feasibility Study that helps us to plan all technical, commercial and financial activities. The social and market impacts expected for FOCALISE in 5 years are an effective microorganism detection, €10.87 million in profits, 18 new people and a ROI of 5.21 per euro.

Keywords: oxygen consumption,biosensor,microplate,fluorescent probe,dairy product assay,microorganism detection,food safety