Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Effects of Far-Right Challenges on International Organizations (FARRIO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1498855.0
EU funding (EUR): 1498855.0
Participants: 1
Project status: SIGNED

The rise of the far right poses a profound challenge to global politics. Diverse far-right actors, such as political parties, civil society groups, and social movements, have been gaining support in domestic contexts, while intensifying their transnational contacts. As these groups focus on national sovereignty and share a stance against globalization, they often contest international organizations (IOs) and their policies. Yet their impact on international organizations differs: On the one hand, far-right groups have profoundly changed negotiations on the Global Compact for Migration in the UN. On the other hand, radical-right parties in the European Parliament have hardly brought about any deeper policy changes. Why does transnational far-right contestation have varying effects on international organizations? While scholars have analyzed far-right actors in domestic politics, knowledge about their transnational activities and effects is limited. FARRIO fills this gap empirically, theoretically, and methodologically. Empirically, it compares effects of far-right contestation on the EU, the UN, and its specialized agencies/treaties in four central policy fields (migration, women's rights, climate change, and public health). Theoretically, it proposes that IO changes depend on the directness of far-right strategies and the liberal character of international organizations. It thereby breaks new ground in identifying scope conditions for far-right impact highly relevant for research on transnational protest as well as IO resilience and change. Methodologically, FARRIO draws on and further develops quantitative and qualitative methods. It adapts protest event and networks analysis to map transnational far-right contestation, also including social media data. Bridging Comparative Politics, Social Movement Studies, and the study of International Relations, FARRIO assesses the challenge far-right actors pose to IOs as well as what measures are suited to respond to it.

Keywords: international organizations contestation,transnational far right
Tracing the FLUX of cosmic dust arriving to Earth during the Phanerozoic (FLUX)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 2631000.0
EU funding (EUR): 2631000.0
Participants: 1
Project status: SIGNED

For the last 4.5 billion years, extraterrestrial (ET) materials have continuously bombarded the Earth. Today, the Solar System debris that reaches the Earth’s surface is dominated by particles less than 2 mm in size, termed micrometeorites (MMs). Until recently, the established misconception was that these MMs did not survive geological timescales, limiting reconstructions of the dust flux through time that are currently based on finding rare relict mineral phases or applying geochemical tools (e.g., Ir contents, 3He isotope ratios). Following a successful proof-of-concept study on a Late Devonian section, FLUX proposes first to extract fossil MMs from selected stratigraphic intervals across the Phanerozoic to document their characteristics and origin and second to use them as a novel high-resolution proxy to better understand the dynamical interactions between the Solar System and Earth. As such, fossil MMs may serve as an alternative new source of information on Solar System processes, complementary to classic meteorites. By combining expertise in meteoritics, geochemistry, and chemostratigraphy, FLUX addresses the following questions: 1) How did the flux of cosmic dust evolve during the Phanerozoic? 2) Can stratigraphic intervals marked by a dramatic increase in the mass of cosmic dust accreting to the Earth be identified? 3) Do increased ET flux events reflect asteroid family-forming events in the asteroid belt between Mars and Jupiter, and are they influenced by changes in the shape of Earth’s orbit? 4) Can oxidized iron-rich MMs be used to reconstruct the gross primary productivity or atmospheric CO2 levels of the deep past? 5) Did ET flux fluctuations affect the global Earth environment, for example through ocean fertilization? Ultimately, FLUX will better position the Earth in the context of a dynamic Solar System and constrain the causes and consequences of the variations in the flux of cosmic dust to Earth.

Keywords: micrometeorites stratigraphy asteroid family forming events atmospheric co2 levels ocean fertilization
Informed Decision-Making for Agroforestry Systems in Africa through a Network of Living Labs (AfroGrow)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Cyprus,Czechia,Greece,France,Belgium,United Kingdom,Germany,Kenya,Zambia,Senegal,Botswana,Switzerland,Ethiopia,Côte d'Ivoire,Spain
Call: EU-African Union cooperation on agroforestry management for climate change adaptation and mitigation (HORIZON-CL6-2024-FARM2FORK-01, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 6045421.25
EU funding (EUR): 5998801.25
Participants: 26
Project status: SIGNED

AfroGrow proposes a comprehensive strategy to promote and advance sustainable agroforestry practices across Africa, addressing key challenges related to climate resilience, biodiversity conservation, and socio-economic development. By focusing on collaboration, innovation, and capacity building, AfroGrow aims to transform agroforestry systems into resilient, multi-functional landscapes that enhance food security, mitigate climate change, and promote inclusive growth. Through a network of six Living Labs, AfroGrow will facilitate participatory research and innovation, enabling local communities, researchers, and policymakers to co-create sustainable agroforestry solutions tailored to diverse ecological and socio-economic contexts. These Living Labs will serve as hubs for knowledge exchange, technology transfer, and capacity building, empowering stakeholders to adopt and implement best practices in agroforestry management. AfroGrow will develop regional suitability maps for local plant species and animal breeds, facilitating informed decision-making for stakeholders. Simultaneously, it will conduct comprehensive impact assessments of regenerative management measures, providing evidence- and data-based recommendations for policy formulation and decision-making. This will enhance ecosystem resilience through sustainable land management practices and secure human well-being. Central to AfroGrow's approach is the promotion of gender equality and social inclusion, recognizing the critical role of women and youth in agroforestry development. By fostering equitable participation and representation, AfroGrow aims to amplify the voices of marginalized groups and ensure that agroforestry interventions benefit all members of society. Through collaborative partnerships, interdisciplinary research, and stakeholder engagement, AfroGrow seeks to catalyze a paradigm shift towards resilient, inclusive, and environmentally sustainable agroforestry systems within the African Union.

Keywords: sustainable agroforestry systems,living labs,soil health,regenerative management practices,suitability maps,impact assessment,gender reponsive approach,ssh,knowledge caravans,co creation
AFROPEMOTIONS: Rethinking Emotions, Inequality, and Resistance through Afropean Women's Fiction (AFROPEMOTIONS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 200400.0
EU funding (EUR): 200400.0
Participants: 4
Project status: SIGNED

AFROPEMOTIONS investigates how the emotional entanglements depicted in 21st-century Afropean women’s fiction in English enable discussions of emotional encounter, inequality, and resistance. The project analyses selected novels (2005–2024) set in different European contexts and depicting the experiences of Afro-descendant (im)migrant women exposed to multiple forms of oppression. Emerging studies reveal how prejudices and discriminatory attitudes/practices stem from the proliferation of negative emotions produced by specific habits or patterns of judgment in predominantly white Western/European societies. By combining an affective approach with gender, intersectional and postcolonial critical perspectives and literary and empirical analysis, the project: 1) proposes the first extensive comparative study of 21st-century Afropean women’s fiction in English with a focus on emotions and their socio-cultural and political implications; 2) aims to raise readers’ awareness about the multiple forms of discrimination faced by African (im)migrant women in Europe, in both fictional narratives and real-life contexts; 3) uses Afropean women’s fiction as a critical site to engage in broader conversations about emotions, inequality, and resistance that move beyond mere literary debates. This two-year action will be undertaken under the supervision of Prof. Elisabeth Bekers at Vrije Universiteit Brussel (VUB) and includes two short secondments in Berlin: at Freie Universität (FU), supervised by Prof. Jan Slaby, and at the Leibniz-Zentrum für Literatur-und Kulturforschung (ZfL), supervised by Dr. Gianna Zocco. The project will comprise transversal training, the acquisition of transferable skills, and targeted dissemination and communication activities, including the organisation of focus groups with VUB’s international students, aimed at discussing innovative ways to engage European citizens in the ‘‘Gender Equality’ and ‘Reduced Inequalities’ goals of Agenda 2030.

Keywords: afropean women s fiction in english anglophone african and diaspora women s fiction emotions affective criticism women and gender studies intersectional studies
Improving monitoring and environmental risk assessment of pharmaceuticals, antimicrobial resistance and pathogens from terrestrial to aquatic environments (Pharm-ERA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,Italy,Spain,Germany,Sweden,Greece,Malta,Switzerland
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-02-01
End date: 2028-01-31
Duration (months): 48.0
Total project cost (EUR): 2890121.14
EU funding (EUR): 2657779.2
Participants: 20
Project status: SIGNED

Global contamination of soil and aquatic ecosystems by pharmaceutical and microbiological pollutants (such as antimicrobial-resistant microorganisms and/or pathogens) raises severe concerns about impacts on ecosystem health and repercussions on humans and animals. Preserving ecosystems from adverse ecotoxicological effects of pharmaceuticals and their transformation products and limiting the environmental spread of antimicrobial resistance and pathogens is imperative to reach several UN Sustainable Development Goals as well as the European Green Deal, Water Framework Directive and Biodiversity Strategy for 2030. To meet these huge environmental and societal challenges, public and private stakeholders and EU policy makers require improved monitoring and Environmental Risk Assessment to protect microbial diversity and functions in contaminated ecosystems. Pharm-ERA proposes a high-level interdisciplinary and intersectoral research and training network based on 10 doctoral projects covering scientific disciplines including environmental and analytical chemistry, microbial ecology, ecotoxicology, molecular biology (incl. multi-omics approaches) and chemical fate/effect modelling. Pharm-ERA involves 9 Beneficiaries (including 2 non-academics) and 6 Associated Partners (including 5 non-academics), committed to contribute to research, training, dissemination, communication and exploitation of results targeting end-users such as Environmental consultancies and agencies. Pharm-ERA will provide EU with high-level scientific experts who will further shape and implement the next generation of environmental management strategies, EU guidelines and regulations to reduce the adverse environmental effects and risks of pharmaceuticals and the spread of antimicrobial resistance and pathogens in terrestrial and aquatic environments. This will ensure sustainability of our ecosystems, fostering positive impacts on human and animal health and well-being far beyond the Pharm-ERA project

Keywords: antimicrobial resistance pathogen microorganisms soil water sediment continuum chemical fate and effect modelling microbial ecotoxicology
Multifunctional Ligands for Enhanced Catalysis (MLCat)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-08-01
End date: 2027-07-31
Duration (months): 60.0
Total project cost (EUR): 1583643.75
EU funding (EUR): 1583643.75
Participants: 1
Project status: SIGNED

Transition metal-catalyzed C-H functionalization replaces an inert carbon-hydrogen bond with a functional group, expediently altering the properties of the parent molecule to access new classes of compounds. Although the C-H functionalization represents a green chemistry approach as it precludes the need for pre-functionalized starting materials, there are still two main sustainability shortcomings with most current methodologies. The first challenge is achieving functionalization of specific C-H bonds without affecting other C-H sites in the molecule. A widely employed strategy to control the selectivity of metal-catalyzed C-H bond functionalization reactions has relied upon the covalent attachment of directing groups (i.e., pyridine, oxime, diazo) to the parent molecule. The requisite installation and removal of directing groups make the overall transformation less appealing from an atom- and step-economy perspective. The second challenge is to substitute commonly used precious transition metals with more benign earth-abundant alternatives. The proposed research program will address these shortcomings by developing an innovative and more efficient way for selective metal-catalyzed functionalization of aromatic and aliphatic C-H bonds without pre-attaching a directing group. The proposed strategies will rely on the design of multifunctional ligands capable of simultaneous binding to the substrate and the transition metal catalyst. The proposed approach will take advantage of the ability of Cr(0) to form an pi-arene complex and activate the aromatic and benzylic C-H bonds. Addressing these challenges associated with C-H activation technology would have the power to unlock many industrial applications, such as valorizing fine chemicals and modifying complex natural products, drug leads, or polymers.

Keywords: catalytic reactions,ligands,c h functionalization,transition metal catalysis
Real-time imaging and mechanistic analysis of Tau fibril disaggregation in live cells (Tau DG RT-imaging)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: CLOSED

Age-dependent neurodegenerative diseases associated with protein aggregation represent one of the most important medical and socio-economic challenges of our time. With the extension of human life span, the prevalence of this group of diseases has markedly increased. Among them, Alzheimer’s diseases (AD) and other dementias have become the second leading cause of death in high-income countries. As a pathological hallmark, Tau amyloid aggregation in the brain has been determined to be closely related to the cognitive impairment in AD and related dementias. Despite major research efforts world-wide, the mechanism of Tau pathology and how its manifestation is prevented in healthy cells is not yet understood. This project builds on recent findings in the host laboratory that the AAA+ ATPase complex of VCP can mediate the disaggregation of Tau fibrils in a cellular model. Consistently, autosomal dominant VCP hypomorph mutations have been found to exacerbate Tau pathology in patients. I will use live cell fluorescence imaging and advanced single-molecule tracking to investigate the mechanism of VCP and cooperating factors in Tau disaggregation in real time. Stable reporter cell lines will be generated in which components of interest carry self-labeling affinity tags to introduce fluorescence signals for single-molecule monitoring. The planned research will provide new insights into the cellular pathways of fibril decomposition and may benefit the development of new therapeutic strategies for tauopathies. The experimental approach to be established in this study can be applied to investigate disaggregation in other neurodegenerative disorders, including Huntington’s and Parkinson’s disease.

Keywords: chaperones protein aggregation single molecule tracking neurodegenerative diseases tau
Microfluidic platform for cancer Intravasation: pass or no pass? (Intrap)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 3123287.0
EU funding (EUR): 3123287.0
Participants: 1
Project status: SIGNED

Cancer still is one of the world’s deadliest diseases. Most devastating is the ability of cancer cells to spread throughout the body in a multistep process called metastasis, the major cause for mortality. A critical step is intravasation, when cancer cells pass a blood vessel wall to enter the blood stream, and travel to another location to create a secondary tumor. However, the mechanisms of intravasation are still largely unexplored, even though it is pivotal: if we can prevent it, cancer does not spread. Intrap aims to enhance our understanding of intravasation through a unique experimental approach. We hypothesize that intravasation is critically controlled by mechanical cues like stiffness, geometry, and adhesive interactions; after all, the act of passing the vessel wall requires mechanical action of the cells: deforming, adhering, detaching, moving, and overcoming mechanical forces. We will take a systematic approach enabling to separately control different mechanical cues, and directly observe their effect on intravasation. The groundbreaking result will be a pass-no-pass phase diagram that shows under which conditions cancer cells can or cannot pass a vessel wall. We will develop an innovative microfluidic platform with a multi-chip architecture for in vitro intravasation testing. In the individual chips we will create blood vessels with varying geometry and permeability, surrounded by extracellular matrices with pre-determined mechanical properties in which different tumor cells or cell clusters with known or controlled mechanical properties will be integrated. We will directly observe the intravasation process using live microscopy. Our platform will open new approaches to cancer research; our discoveries will expand our scientific knowledge of metastasis. Beyond Intrap, the obtained insights can contribute to the development of highly needed novel cancer treatments that intervene with mechanical properties of cancer cells, matrix or blood vessels.

Keywords: microfluidics organ on a chip metastasis intravasation