Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
qPCR Microfluidics point-of-care platform for dengue diagnosis (DENVPOC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-18
End date: 2022-05-17
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

As a result of Global climate change and fast urbanization, global outbreaks of Dengue (DENV)/ Zika(ZIKV)/Chikungunya(CHIKV) virus have the potential to occur. The most common pathway of these infections in humans is through the female Aedes mosquito vector. DENV is an exanthematous febrile disease with varied clinical manifestations and progressions . Due to similarities in symptoms between DENV and ZIKV and CHIKV, it is difficult to make a differential diagnosis, impeding appropriate, timely medical intervention. Furthermore, cross-reactivity with ZIKV, which was recently related to microcephaly, is a serious issue. In 2016, in Brazil alone, there were 4180 microcephaly cases reported instead of 163 cases, more in line with yearly expected projections , , Thus, the sooner an accurate diagnostic which differentiates DENV from the other manifestations is critical; most especially at the early stages of the infection, to have a reliable diagnosis in pregnant women. In 2016, the OMS emergency committee declared that the outbreaks and the potentially resultant neurological disorders in Brazil were an important international state of emergency in public health, as a result of the associated secondary effects; these diseases became a Global concern. This project allows developing a highly and fast Multiplex qPCR POC platform by using FASTGENE technology with a minimal amount of patient serotype. It would reduce the time of analysis (30 to 90’ for a standard) and costs. Additionally, the sample preprocessing and thermalization will shorten real-time PCR amplification time and will be integrated within the microfluidic systems. This platform can result in a commercialized product whereupon a main market target would be pregnant women and people living or traveling through/from outbreak risk areas.

Keywords: microfluidics,dengue diagnosis,point of care,qpcr
3D architectures of Mxenes for Terahertz Applications (3D-AM-TERA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Czechia
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 156980.64
EU funding (EUR): 156980.64
Participants: 1
Project status: SIGNED

The terahertz (THz) region of the electromagnetic spectrum finds application in different areas such as security checks, biology, detection of drugs and explosives, imaging and astronomy. The state-of-the-art THz detectors lack high sensitivity, fast operation, and portability. The proposed work will explore the possibility of significantly advancing the THz radiation detection process by using 2D MXene materials combining advanced developments in two frontier research areas, 3D printing of 2D materials with dedicated investigation on their ultrafast far-field and near-field THz spectroscopic properties. MXenes are nanometer thick conductive sheets and their interaction with the THz radiation can be strengthened by arranging them into a 3D pattern. To address the concept of novel devices made of MXene sheets with enhanced light-matter interaction, I propose to develop 3D printing technology able to create a sample interaction area with specifically arranged 2D sheets in 3D structures exhibiting complex percolation pathways, where all the atoms will be exposed to the THz light. This will allow maximum photon absorption in the entire photoactive assembly and thereby maximum photocurrent generation. The project will answer questions of key intrinsic parameters of layered MXenes (attached functional groups, doping, defects) and of the role of the 3D structuring for optimizing the THz response and, ultimately, to what extent the 3D printing of 2D MXenes can fill the THz gap in the development of novel devices.

Keywords: mxene,terahertz spectroscopy,3d printing,photophysics
Molecular Electron Dynamics investigated by IntensE Fields and Attosecond Pulses (MEDEA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Spain,Austria,Germany,Germany,Germany,Germany,Italy,Italy,Belgium,Sweden,Greece,France,France,Denmark,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3896490.22
EU funding (EUR): 3896490.2199999997
Participants: 20
Project status: CLOSED

The interaction of matter with light is one of the most fundamental processes occurring in nature with countless scientific and technological applications. In recent years, the continuing development of intense, ultrashort, coherent light sources from the mid-infrared (mid-IR) to the extreme ultraviolet (XUV) spectral range has opened new possibilities for the investigation of this interaction in new and complementary domains. In both the IR and XUV regimes, molecules and clusters of atoms interacting with light exhibit (correlated) multi-electron dynamics evolving on the few femtosecond (1 fs=10-15 s) to attosecond (1 as=10-18 s) timescale. Several experimental and theoretical investigations suggest that ultrafast multielectronic processes might be fundamental in determining the behaviour of molecules and clusters, and that understanding these phenomena might offer new perspectives on processes occurring on “slower” timescales, such as bond-breaking in complex molecules and Coulomb explosion in charged clusters. In this context, the main objectives of the MEDEA network are: 1) to advance attosecond and femtosecond XUV spectroscopy in molecules and clusters 2) to demonstrate the feasibility of nonlinear attosecond XUV spectroscopy, 3) to obtain benchmarks for the validation of attosecond tools and femtosecond XUV pulses for the time-resolved imaging of electron and nuclear dynamics in molecules, 4) to contribute to the development of new technological solutions that will increase the competiveness of the industrial partners 5) to train a group of early stage researchers (ESRs) and contribute to their career prospects, and 6) to increase the interest of young students in the network’s core research field (Photonics) by introducing a dedicated experimental kit in several European secondary schools.

Keywords: attosecond pulses,high order harmonic generation,cold molecular and cluster beams,extreme ultraviolet generation,free electron lasers
Integrated DEsign and control of Sustainable CommUnities during Emergencies (IDEal reSCUE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-11-01
End date: 2021-04-30
Duration (months): 66.0
Total project cost (EUR): 1271138.0
EU funding (EUR): 1271138.0
Participants: 1
Project status: CLOSED

Integrated DEsign and control of Sustainable CommUnities during Emergencies

Keywords: infrastructure interdependencies,resilience,performance,community resilience,critical infrastructures
Cluster decorated recognition elements on DNA origami for enhanced raman spectroscopic detection methods (DeDNAed)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Austria,Germany,Spain,Germany,France
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-03-01
End date: 2024-02-29
Duration (months): 36.0
Total project cost (EUR): 2994354.19
EU funding (EUR): 2994354.19
Participants: 7
Project status: SIGNED

The project "DeDNAed" is intended to develop a novel, innovative biosensing platform whose advantages and benefits are in terms of sensitivity, versatility and being ultrafast by an optical approach. Our platform will be based on the assembly and integration of sensing elements (transducer and bioreceptor) by DNA origami. The DNA origami will serve as a “nano bread board” in order to precisely control the position of these elements and thus the sensor architecture at the nanometer scale. Metallic atomic clusters (ACs) are integrated into a biological marker molecule (DNA or antibody) and thus represent the biological sensor element. This is specifically integrated into a nanoarray made of additional metallic nanoparticles precisely controlled by a DNA origami template and will lead to a significant increase in signal. DNA origami serves as an individually inter- and intramolecularly programmable nano bread board. A DNA origami consists of a single strand of DNA, folded by a thermal treatment and certain staple strands into any shapes (2D as well as 3D, dimensions between 10 and several 100 nanometers). So-called "sticky ends" on the surface of the DNA origami offer the possibility of an individual implementation of the sensing elements and NPs, by means of correspondingly complementary oligonucleotides with a resolutions of 2 nm. When the analyte is connected to the sensor element, a change in the Raman signal can thus be detected without major delay using surface-enhanced Raman spectroscopy (SERS). This sensor method is not bound to a specific biomarker molecule for the sensor element, but can be transferred to different marker molecules. This means a high degree of flexibility in the area of application, from medical technology to food monitoring. In addition, a transfer of the DNA origami-based sensor platform to flexible, textile substrates is carried out using lipid bi layers and the Langmuir-Blodgett method for later use as a wipe test or medical wearable.

Keywords: lable free,dna origami,biosensing,atomic cluster,sers
Tracking interactions between RNA and RNA-binding proteins by thermal profiling of the proteome (meltRBP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

RNA-binding proteins (RBPs) are among the key players in post-transcriptional gene regulation. A detailed knowledge of the RBPs bound to a specific RNA target is critical to the unravelling of the regulatory steps of RNA expression under normal and disease conditions. However, the study of these interactions is complex and requires methodologies that go beyond the scope of individual RBPs. So far, the techniques have been confined to post-lysis protein or RNA enrichment, which limits the identification of non-abundant targets and often relies on the insertion of tags. To solve these issues, thermal proteome profiling (TPP)—relying on the stabilisation of the endogenous protein through the binding of its ligand—will be applied in this project. Here, using mass spectrometry, TPP will be applied to investigate complex RBP-RNA interactions on a proteome-wide level in an unbiased manner ('meltRBP'). First, the methodology will be benchmarked with the help of a well-characterised interaction: the iron regulatory proteins and their RNA target, the iron response element (IRE). Secondly, TPP will be applied to a biologically relevant system, namely the mRNA of the Amyloid Beta Precursor Protein (APP). The proteolysis of mutant APP proteins, which are generated from alternatively spliced mRNAs, generates highly aggregation-prone β-amyloid peptides, a hallmark of Alzheimer’s disease (AD). The application of TPP to identify RBPs bound to the wild-type versus mutant APP mRNA will reveal new potential targets for AD treatment. Finally, TPP will be used to determine the specificity of the hybridisation of antisense oligonucleotides (ASOs), currently of great interest to the field of neurodegenerative disease treatment and whose global cellular effects have thus far not been investigated in a high-throughput manner. In summary, this proposal encompasses the benchmarking and application of an innovative proteomic technique, that has the potential to function as a screen for ASOs.

Keywords: thermal proteome profiling,post transcriptional regulation,antisense oligonucleotide screen,alzheimer s disease
The Architecture of William Burn: Style and Identity in Scotland's Imperial Age (BURN-BEYOND)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-08
End date: 2023-09-07
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

BURN-BEYOND is a study of the Scottish architect William Burn (1789-1870), the progenitor of ‘Scots Baronial’ architecture, one of the earliest and most distinctive examples of a self-consciously ‘national’ revivalist style. Burn’s career spanned the period when the world was being transformed by British imperial and economic power and by the aftermath of the French Revolution, when architecture became an enduring vehicle for defining national, political and social identities. His achievement was to formulate a pro-Scottish architectural identity that was simultaneously accepted as pro-establishment and British. His work is of special contemporary relevance given the recent resurgence of nationalist politics in the face of contemporary trends towards economic and cultural globalisation. This study will articulate debates over architectural style and national identity in Britain and beyond, and show that, through Burn’s work, the Scots foreshadowed the later 19th-century quest to establish political or cultural difference through national or pseudo-national architectural revivalism. Using innovative approaches to stylistic, spatial and historical analysis, this project will explore the construction of national, imperial, political and gender identities in Burn’s work. It will seek to: establish the motivations for and implications of Burn’s unrivalled stylistic diversity; demonstrate how Burn contributed to the formulation of a Scottish architectural identity; and understand how his famously ingenious domestic planning shaped gender, familial and social relationships. It will therefore generate new insights into the interactions between stylistic choice and social, cultural and political identities in Europe in the Romantic era, and enrich studies of politics, literature, gender relations, the visual arts and nationalism. It will be of particular value to historians studying the emergence of stylistic nationalism elsewhere.

Keywords: architecture,style,national identity,gender,cultural history,scotland,britain,europe,empire,19th century
A bird’s (social) life: development and senescence in wild social networks. (SOCIALIFE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: TERMINATED

Over the course of an individual’s lifetime, the strength and type of social interactions change markedly with age. Because social interaction underpins many aspects of fitness, the contributions of age-related changes in social behaviour to fitness variation are a key process to understand. Yet, little work has been possible owing to the challenges of quantifying social behaviour in large numbers of individuals over their lifetimes. I thus aim at testing the hypothesis that age-related variation in social behaviour contributes to age-related changes in survival and reproduction. The project will make the most of the exceptional novel infrastructure and statistical approaches developed by my host group in Oxford to quantify and manipulate social interactions in free-living birds. Extensive longitudinal data on great tits Parus major from 2011 to 2016 will be used to quantify variation in social interactions with age from an individual perspective. A particular focus will be on the effect of dispersal and familiarity on social development. Social data will then be combined with breeding data from the long-term monitoring of the population to test correlationally whether social interactions relates to reproduction and survival. The role of interactions with adults in social development and early reproductive performance will be experimentally tested by segregating the access to different feeders according to age. A translocation experiment will also test the impact of dispersal on social development and performances. Overall, this research will break new ground in our understanding of the determinants and consequences of social behaviour.

Keywords: social networks,social interactions,fitness,life history strategies
Vision, Insights and Trends for Awareness and Leadership in Media (VITAL MEDIA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Spain,Italy,Italy,Italy,Germany,France,France,United Kingdom
Call: Technologies for creative industries, social media and convergence (H2020-ICT-2015, 2015)
Start date: 2016-06-01
End date: 2018-06-30
Duration (months): 25.0
Total project cost (EUR): 979780.0
EU funding (EUR): 979780.0
Participants: 10
Project status: CLOSED

Recent research activities in the ICT area, in particular in digital content and media sectors, has resulted in a number of technological enablers which allow the creation of new products and services. This has established a new converged social media environment in Europe as a playground for a large number of stakeholders, to ultimately enable creation of the related business, new jobs, and revenues benefiting from these developments. However, the main drivers of the new media and content technologies are the big industries, whereas the main users of these technologies are small enterprises / SMEs, which are creating product and services to reach the end customers – European and world-wide citizens. We can still observe a gap in discussions between the large technology providers and the small technology adopters, preventing the establishment of common strategies for the technology take up towards a more efficient creation of the new innovative product and services. Therefore, there is a clear need for the establishment of a common European community in the area of convergence and social media, in order to lay-down common research and innovation strategies, by involving important players from academia and research institutions, policy makers, end users, etc. Accordingly, one of the main goals of the VITAL MEDIA project is to enlarge the community in the social media area at the European level, at level of the national and regional clusters, through collaboration amongst the NEM Initiative and the clusters. The enlarged community will be animated through a number of discussions at workshops to be organised at all mentioned levels and through cooperation within an innovative online collaboration tool, aiming to widely discuss and establish research and innovations roadmaps for the area, by strong cooperation with research and academic institutions active in the area, covering the identified gaps between the technology providers, their users/adopters, and research.

Keywords: convergence and social media,community enlargement and animation,strategy development
Role of perforin-like proteins and phospholipases in malaria parasite egress (MalariaEgress)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2020-01-07
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The malaria parasite Plasmodium falciparum, which causes ~600,000 deaths annually, propagates within host erythrocytes. Roughly synchronous egress of blood stage parasites in vivo causes the periodic fevers associated with malaria and is essential for parasite replication. Blocking parasite egress can stop disease progression, so understanding its mechanism is key to identifying new drug targets. Egress of malaria parasites from host erythrocytes involves the rupture of two membranes- the parasitophorous vacuole membrane and the erythrocyte membrane. It is unclear how the parasitophorous vacuole membrane ruptures during egress, and what mechanism is responsible for poration of the erythrocyte membrane. While it has been shown that egress is protease-dependent, the effector molecules that bring about the disruption of both membranes remain unknown. Potential effector molecules include parasite perforin-like proteins (PLPs) and phospholipases. This project aims to test the hypothesis that Plasmodium PLPs and phospholipases are involved in malarial egress. First, we will apply newly developed conditional knockout strategies to establish the role in egress of a candidate perforin-like protein. Second, we aim to devise a novel conditional genetic screen to identify egress related phospholipases in a medium-throughput manner. This work will add to the efforts being made to understand egress and will attempt to develop a much needed forward genetic screen in the malaria parasite. The interdisciplinary approach proposed here combines the experienced researcher (ER)’s skills in genomics and the host laboratory’s expertise in malarial cell biology and conditional knockout technologies. This will equip the ER with the right exposure and new skills to pursue a future independent research career in malaria research.

Keywords: malaria,plasmodium,egress,perforin like proteins,phospholipases,dicre conditional mutagenesis