Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
HER Imaging and Molecular Interaction Mapping in Breast Cancer (IMAGINT)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: United Kingdom,Switzerland,Germany,Sweden,Spain,France,France,Finland
Call:  (FP7-HEALTH-2010-two-stage, 2010)
Start date: 2011-05-01
End date: 2015-04-30
Duration (months): 48.0
Total project cost (EUR): 7411567.4
EU funding (EUR): 5683589.75
Participants: 11
Project status: CLOSED

The aim is to develop tools for imaging and characterising protein/protein and protein/RNA interactions in cancer using Designed Ankyrin Repeat Proteins (DARPins). DARPins are small, ultrahighly stable, antibody-like proteins that bind specific targets with high affinity in monovalent form and are readily engineered for site-specific chemical modification. The exemplar protein family will be EGFR, with focus on HER2-mediated processes in cancer. 1. EGFR-reactive DARPins will be used to characterise HER2 homo- and hetero-dimers using 4 novel technologies: Single Molecule Fluorescence, Proximity Ligation, super-resolution microscopy and FRET/FLIM. The collected data will be analysed with information on clinical outcome to determine which HER2 interactions are associated with resistance to HER2 targeted treatments. 2. Protein/RNA complexes will be isolated and characterised. These complexes may be new biomarkers for breast cancer and their characterisation is aimed at elucidating mechanisms of transcriptional regulation in response to anti-HER2 treatment. 3. Protein networks associated with EGFR signalling by imaging clusters of at 50-100 different proteins in a single cell or tissue section. This will be achieved with a robot, using large dye-conjugated tag libraries, and automatically bleaching a dye after imaging and re-labelling with another. 4. Whole body imaging (Phase I/II) clinical trial will use radiolabelled anti-HER2 DARPins to improve specificity and sensitivity of quantitative PET/SPECT/CT. The trial aims to image HER2 positive metastatic cancer and provide circulating tumour cells (CTCs) and biopsies for more detailed analysis. 5. Multivariate data obtained by the new technologies will be analysed with a range of bioinformatic tools, including artificial neural network methods, to determine novel biomarkers that aim to classify breast cancer patients at an individualised level. The outcome is to increase the tool panel of clinicians.

Keywords: bio-imaging,her1,her2,her3,her4,fret,biomarkers,darpins,flim,ctcs,drug resistance,mirna
Effective Perinatal Intensive Care in Europe: translating knowledge into evidence based practice (EPICE)

Framework: FP7 — Cooperation
Programme: Health
Destination: Optimising the delivery of healthcare to European citizens
Action type: Collaborative project
Countries involved: France,United Kingdom,Netherlands,Germany,Poland,Denmark,Portugal,Italy,Sweden,Estonia,Belgium
Call:  (FP7-HEALTH-2010-two-stage, 2010)
Start date: 2011-01-01
End date: 2015-12-31
Duration (months): 60.0
Total project cost (EUR): 3967513.79
EU funding (EUR): 2999708.0
Participants: 13
Project status: CLOSED

Context: Very preterm infants face high risks of mortality and long-term neuro-developmental impairment. Rates of mortality and morbidity vary by a factor greater than two between European regions. This project’s overriding aim is to improve these infants’ survival and long-term health and development by ensuring that available medical knowledge is translated into effective perinatal care. Objectives: (1) Build an empirical knowledge base concerning how scientific evidence is translated into health service provision in maternity and neonatal units by measuring the use of key medical interventions in clinical settings, identifying the factors associated with adoption of evidence-based practices and providing updated information on the effectiveness of medical practices; (2) Assess decision-making and knowledge implementation processes within units and regions to identify catalysts for evidence-based practice; and (3) Propose intervention strategies to achieve behavioural change. Study design: This project combines quantitative and qualitative approaches to assess the use of evidence-based medical interventions and determinants of use on the regional, unit and patient level in 19 European regions (≈550 units, ≈ 10,500 births). The project includes a population-based cohort study of very preterm infants with follow-up to 2 years of age, a survey of all maternity and neonatal units caring for these infants, semi-structured narrative interviews and focus groups in selected units and case studies on regional governance. Impact: The project will produce empirical data about the uptake of medical interventions in European maternity and neonatal units and new knowledge about catalysts for the adoption of medical knowledge. Its results will provide a methodological and conceptual basis for future scientific work on the effectiveness of intervention strategies. The project enhances cooperation and excellence in Europe by bringing together national research initiatives.

Keywords: very preterm infants,neonatal intensive care,evidence based practices,knowledge dissemination,epidemiology,qualitative methods,public health
The DNA damage response and breast cancer (DDRESPONSE)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Netherlands,United Kingdom,Denmark,United Kingdom
Call:  (FP7-HEALTH-2010-two-stage, 2010)
Start date: 2011-02-01
End date: 2015-01-31
Duration (months): 48.0
Total project cost (EUR): 8165981.0
EU funding (EUR): 6000000.0
Participants: 6
Project status: CLOSED

We will exploit the DNA damage response (DDR) to assess and predict individual susceptibility and response focussed on breast cancer and breast cancer therapies. The 1st targeted therapy based on the DDR is inhibition of PARP by olaparib, which induces synthetic lethality in cancer cells with a specific DDR defect. Our members discovered olaparib, which is currently in Phase II trials. Its use in DDR deficient cancers represents a truly personalised healthcare approach. Due to the complexity of the DDR more therapeutically exploitable cases of synthetic lethality are to be discovered, which may be applied to specific tumours and patients. To this end our objectives include: To determine key differences in the DDR between cancer and normal cells, because they constitute important targets for directed individual therapy; establish the roles of DDR mechanisms as these relate to damage induced by anti-cancer therapies to explain inter-individual variation in therapy response; define how different DDR pathways compensate for one another, because this may suggest how targeting one DDR component with a drug could have marked cytotoxic effects on a cancer but not on normal cells; develop and validate markers for functionality of the DDR in fresh tumour biopsies, directly from the clinic, for selection of patients for personalised treatment. Collectively, this consortium has an unrivalled depth and breadth of expertise. We have access to a wide range of new and emerging technologies, while we bring complementary strengths to the project with regard to topics, models, materials, techniques and clinical links, which include the two largest cancer hospitals in Denmark and the Netherlands. Thus, the consortium represents the ‘state-of-the-art’ and has the scope to evolve their knowledge of the DDR into new and exciting areas for assessment of individual susceptibility and prediction of individual responses to cancer therapies, as well as development of new anti-cancer therapies

Keywords: ddr biomarkers,genome maintenance,synthetic lethality,tumour ddr status
Industrialised energy efficient retrofitting of resident buildings in cold climates (E2REBUILD)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Energy efficiency and savings
Action type: Collaborative project
Countries involved: Sweden,Poland,Sweden,Switzerland,Germany,Finland,France,Germany,Netherlands,Germany,Germany,United Kingdom
Call:  (FP7-2010-NMP-ENV-ENERGY-ICT-EeB, 2010)
Start date: 2011-01-01
End date: 2014-06-30
Duration (months): 42.0
Total project cost (EUR): 7843338.67
EU funding (EUR): 4716490.0
Participants: 21
Project status: CLOSED

The vision of E2ReBuild is to transform the retrofitting construction sector from the current craft and resource based construction towards an innovative, high-tech, energy efficient industrialised sector. E2ReBuild aims to - investigate, promote and demonstrate cost effective and advanced energy efficient retrofit strategies that create added value for existing apartment buildings and endorse end-users to stay and build a dynamic society - to establish and demonstrate sustainable renovation solutions that will greatly reduce the energy use - to create a holistic industrialised process that minimises technical and social disturbance for tenants and facilitates energy efficient operation and use of the buildings including encouraging energy efficient behaviour This will be achieved by transferring technical innovations and advances from research to application and wide use. It will also change current inefficient way of doing business to a “win-win” situation for all involved actors. By understanding and matching the needs of stakeholders a holistic, new design and decision tool will be introduced. E2ReBuild will create added values by optimizing space use, improving comfort and integration of advanced technologies. By introducing industrial manufacturing methods and standardise retrofit measures that allow a high replication potential (60 % of existing apartment buildings for the studied regions and period), the energy use (during construction and operation) and waste can be minimised, ad, the quality and indoor environment can be improved. E2ReBuild will demonstrate, monitor and evaluate proposed technologies, processes and measures in 7 full-scale residential building projects, with typologies representative for large geographical areas in Europe.

Keywords: energy efficient retrofitting,residential buildings,industrialisation,innovation,demonstration
Intelligent Dynamics for fully electric vehicles (ID4EV)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Contribution of the ICT Theme to Public-Private Partnerships for R&D in the European Economic Recovery Plan
Action type: Collaborative project
Countries involved: Germany,Germany,France,Germany,Spain,Sweden,Netherlands,Italy
Call:  (FP7-2010-ICT-GC, 2010)
Start date: 2010-06-01
End date: 2012-10-31
Duration (months): 29.0
Total project cost (EUR): 6717976.0
EU funding (EUR): 3796522.0
Participants: 8
Project status: CLOSED

The objective of the ID4EV project is to develop energy efficient and safe brake and chassis systems for the needs of fully electric vehicles and the improvement of active safety and comfort for a faster introduction of fully electric vehicles. These systems will be optimized to the requirements for FEVs. Beside the development and optimization of the most relevant sub-systems of a vehicle with regard to active safety and comfort, the brake and the chassis system, optimization on vehicle level will done with a new approach of a network system as well as new HMI concepts for FEVs. Electrified auxiliaries like the brake systems and the chassis will lead to new possibilities to vehicle control and a better cooperative interaction between these distributed systems. For a fast introduction of fully electric vehicles these systems have to be safe and must have a defined fail safe concept. The aim is to provide absolute safe electrified brake and chassis systems that lead to a high user/customer acceptance. To reach this safety approach the target is to adapt existing systems to the requirements of fully electric vehicles. The project will concentrate on the topics of energy efficiency, safety and the interaction between the vehicle, the optimized systems and the driver. To address both possibilities of drivetrain concepts of fully electric vehicles, both concepts will take into account and their impact of the adapted systems will be analysed and solutions presented. To reach a significant breakthrough of fully electric vehicles the adapted systems will be tested on test benches and under real world conditions in demonstrator vehicles to ensure the functionality and to prove the safety.

Keywords: fully electric vehicles,efficiency,powertrain,safety,wheel motors,brakes,suspension
ICT Platform for Holistic Energy Efficiency Simulation and Lifecycle Management Of Public Use Facilities (HESMOS)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Contribution of the ICT Theme to Public-Private Partnerships for R&D in the European Economic Recovery Plan
Action type: Collaborative project
Countries involved: Germany,Finland,Netherlands,Germany,United Kingdom,Slovakia
Call:  (FP7-2010-NMP-ENV-ENERGY-ICT-EeB, 2010)
Start date: 2010-09-01
End date: 2013-12-31
Duration (months): 40.0
Total project cost (EUR): 4646330.0
EU funding (EUR): 2699850.0
Participants: 6
Project status: CLOSED

HESMOS will achieve an industry-driven holistic approach for sustainable optimisation of energy performance and emissions (CO2) reduction through integrated design and simulation, while balancing investment, maintenance and reinvestment costs. The objective is to close the gaps between existing intelligent building/facilities data so that complex lifecycle simulation can easily be done in all design, refurbishment and retrofitting phases where the largest energy saving potentials exist. This will be achieved by (1) extending existing BIM, energy simulation and cost calculation tools, so that they can seamlessly exchange the required data, (2) integrating advanced energy simulation tools into the design and FM process, so that BIM-CAD and FM tools can be used as building energy simulator and gap identifier, (3) developing new applications that can visualize building performance in easy to understand way and can quickly display impacts of changed building/space parameters, (4) developing new “Cockpit functionality” in BIM-CAD on EPBD basis to provide fast feedback of the impact of design parameters on lifecycle energy performance, (5) extending BIM-CAD to model and manage buildings and surrounding areas, and (6) ex¬tending BIM-CAD by web services to act as Integrated Virtual Energy Laboratory (IVEL) enabling the study of design and retrofitting alternatives concerning energy performance and total costs. An innovative SOA around the kernel functionality of BIM-based CAD/FM will be applied. Information interoperability will be achieved by enhancing BIM with energy and emissions features to a new sharable eeBIM. Intelligent access methods and a specialised ontology will be developed to enable multi-system integration and management of material, climate and product databases and data from sensor networks and other ICT sub-systems into CAD/FM. An extensive 30-month validation program at 2 PPP projects will be carried out during the project.

Keywords: energy efficiency,ict,building energy simulation,public use facilities,ppp
FEMTOSECOND LASER PRINTER FOR GLASS MICROSYSTEMS WITH NANOSCALE FEATURES (FEMTOPRINT)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: New production
Action type: Collaborative project
Countries involved: Netherlands,France,Switzerland,United Kingdom,Germany
Call:  (FP7-2010-NMP-ICT-FoF, 2010)
Start date: 2010-05-01
End date: 2013-04-30
Duration (months): 36.0
Total project cost (EUR): 3391779.8
EU funding (EUR): 2493468.0
Participants: 9
Project status: CLOSED

FEMTOPRINT is to develop a printer for microsystems with nano-scale features fabricated out of glass. Our ultimate goal is to provide a large pool of users from industry, research and universities with the capability of producing their own micro-systems, in a rapid-manner without the need for expensive infrastructures and specific expertise. Recent researches have shown that one can form three-dimensional patterns in glass material using low-power femtosecond laser beam. This simple process opens interesting new opportunities for a broad variety of microsystems with feature sizes down to the nano-scale. These patterns can be used to form integrated optics components or be ‘developed’ by chemically etching to form three-dimensional structures like fluidic channels and micro-mechanical components. Worth noticing, sub-micron resolution can be achieved and sub-pattern smaller than the laser wavelength can be formed. Thanks to the low-energy required to pattern the glass, femtosecond laser consisting simply of an oscillator are sufficient to produce such micro- and nano- systems. These systems are nowadays table-top and cost a fraction of conventional clean-room equipments. It is highly foreseeable that within 3 to 5 years such laser systems will fit in a shoe-box. The proposal specific objectives are: 1/ Develop a femtosecond laser suitable for glass micro-/nano- manufacturing that fits in a shoe-box 2/ Integrate the laser in a machine similar to a printer that can position and manipulate glass sheets of various thicknesses 3/ Demonstrate the use of the printer to fabricate a variety of micro-/nano-systems with optical, mechanical and fluid-handling capabilities. A clear and measurable outcome of Femtoprint will be to be in a situation to commercialize the ‘femtoprinter’ through the setting-up of a consortium spin-off. The potential economical impact is large and is expected in various industrial sectors.

Keywords: laser manufacturing,microtechnologies,microsystems,glass
Customised Wearable Functionality and Eco-Materials – Extending the limits of Apparel Mass customisation (MICRO-DRESS)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: New production
Action type: Collaborative project
Countries involved: Greece,Finland,Germany,France,France,Italy,Germany
Call:  (FP7-2010-NMP-ICT-FoF, 2010)
Start date: 2010-09-01
End date: 2013-08-31
Duration (months): 36.0
Total project cost (EUR): 4011482.6
EU funding (EUR): 2875549.0
Participants: 10
Project status: CLOSED

The Micro-Dress project aims to extend the limits of feasible garment customisation for men’s, and ladies’ garments, to include for the first time user-configurable wearable functionality, as well as user-selectable degree of material eco-friendliness. The challenges related to both added value aspects will be researched in order to prove these concepts within a pragmatic framework based on two distinct business/supply chain models: i) Extension of existing mass customisation model of an International Brand (Ermenegildo Zegna), ii) Expansion of an innovative mass-customisation model (micro-factories), targeting innovative SMEs. The Objectives are: - Development and deployment of direct-write rapid manufacturing techniques for the production of portable garment integrated microelectronics components. - Derivation of eco-efficiency and eco-logistics related prediction algorithms and web-tools enabling user configurable eco-certification, based on materials and processes information along the supply chain (yarn to garment). - Development of a new biosensor-based screening test which can revolutionise the process of consumer health related garment components screening (fabrics, accessories, etc). - Development of an e-supply chain management platform to model the sourcing of e-devices and the concept of configurable eco-certification along the two supply chains (vertical brand chain, supply network of micro-factories). The platform will be built on the principle of Software as a Service, to maximise it’s exploitation potential. The results will be demonstrated by two pilots, one focussing on the user configurable eco-certification, the second on the customisable attachment of safety e-devices. The project brings together a multidisciplinary Consortium of 9 partners, of which 5 are SMEs, two are prominent EU Institutes and two are leading Textile and Clothing Groups.

Keywords: rapid manufacturing,direct-write technologies,smart garments,mass customisation,eco-efficiency,eco-logistics,e-supply chain management,bionsensors,micro-factories
Development of a novel and cost-effective range of nanotech improved coatings to substantially improve NIR (Near Infrared Reflective) properties of the building envelope (COOL-COVERINGS)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Nanosciences and Nanotechnologies
Action type: Collaborative project
Countries involved: Spain,Italy,Poland,Italy,Greece,Netherlands,Finland,Germany,Germany,Switzerland
Call:  (FP7-2010-NMP-ENV-ENERGY-ICT-EeB, 2010)
Start date: 2010-06-01
End date: 2013-05-31
Duration (months): 36.0
Total project cost (EUR): 4294985.0
EU funding (EUR): 3000000.0
Participants: 14
Project status: CLOSED

Recent work has shown the possibility to drastically increase the reflection performance of the building envelop, using nanotechnologies. Standard metal oxides are already known for their solar reflection properties, but latest developments identified that nanotechnologies can improve Index of Reflectance from an average of 0,35 to 0,85 because of their effectiveness on Near Infrared wavelengths, even on non white surfaces. The NIR reflective COOL-Coverings Project aims to develop an easy to use and cost-effective range of coatings that can be rapidly offered in the market of retrofitting and new constructions: (1) on the external walls; (2) on façades ceramics; (3) on the roofs, for which an already existing new generation membrane will incorporate a nanotechnological-based NIR reflecting coating; (4) on the internal walls and tiles, since the NIR-Reflecting nanocrystalline oxides can be developed in such a reflection range that may also cover the radiation from indoor heating systems. Glazed envelops and windows have not been considered in the scope of the project since several players are already active with a considerable amount of scientific papers. First simulations showed that NIR reflective solutions allow interesting savings in cooling and heating bills, and pay off rapidly the initial investment. The more competitive target will be air-conditioned buildings with flat roof in hot Mediterranean coast, while there is a clear evidence that also buildings in northern continental climates will payoff the additional investment in the NIR technology, due to reflective properties of the internal walls.

Keywords: cool coverings,building envelop,near infrared solar reflection,tiles,walls,roofs,membranes,coatings,nanotechnologies,internal walls heat reflection