Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MINAPATH: A novel and unique method to diagnose and prevent diseases that are caused by exposure and accumulation of inorganic mineral dusts. (MINAPATH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-08-01
End date: 2018-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Today healthcare faces critical challenges coming from an ageing population and the rise of chronic diseases. With a population expected to reach 9 billion people by 2050, healthcare expenditure is at risk of becoming unsustainable. Sustainability requires diagnostic methods to become more efficient, fast and accurate, to facilitate the use of adequate therapy. Despite the effort being made, there are still many diseases that get categorized as idiopathic (unknown cause). Specially in the lung, many inflammatory conditions fall under idiopathic category and stay undiagnosed, while slowly progressing, deteriorating the patient’s quality of life. However, many idiopathic conditions do have a common factor: exposure to mineral dusts such as asbestos, silica or metals (nickel, cadmium & cobalt). We are all at risk of exposure to these minerals, from the environment and workplace, being an occupational hazard in industrial settings and construction sites. Importantly, many of these mineral dusts are carcinogenic, contributing to the increasing prevalence of cancer globally. Despite their impact, today there are no dedicated diagnostic tests to assess mineral exposure, and diagnosis is mostly based on exclusion. In response, we at Minapath have developed a unique method that combines qualitative & quantitative analysis to diagnose the patient’s mineral exposome, serving to identify the underlying cause behind many cases of inflammatory & cancer conditions. After demonstrating the diagnostic relationship between mineral deposits and idiopathic pulmonary diseases, our goal with this project is to finalise the development of our technology and reach market maturity. To achieve these goals, in Phase 1 we aim to carry a Feasibility Study that help us prepare for the main technical, commercial and financial aspects influencing the project. Once completed, our technology will bring significant impacts to society and healthcare, contributing to its efficiency and sustainability.

Keywords: respiratory diseases,rapid diagnostics,inorganic dusts,idiopathic diseases,mineral exposome,quantitative diagnosis,accurate therapies
NEW DEPENDABLE ROLLING STOCK FOR A MORE SUSTAINABLE, INTELLIGENT AND COMFORTABLE RAIL TRANSPORT IN EUROPE (ROLL2RAIL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Austria,Germany,Germany,Germany,Spain,Spain,Spain,Spain,Italy,Italy,Italy,Italy,Germany,Austria,Slovakia,Sweden,Belgium,Sweden,Sweden,France,France,France,France,France,Czechia,United Kingdom,United Kingdom,United Kingdom
Call: New generation of rail vehicles (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-05-01
End date: 2017-10-31
Duration (months): 30.0
Total project cost (EUR): 16000000.0
EU funding (EUR): 16000000.0
Participants: 43
Project status: CLOSED

The ROLL2RAIL project aims to develop key technologies and to remove already identified blocking points for radical innovation in the field of railway vehicles, as part of a longer term strategy to revolutionise the rolling stock for the future. The high level objectives of the work are to pave the way to: • Increase the capacity of the railway system and bring flexibility to adapt capacity to demand • Increase availability, operational reliability and therefore punctuality of the vehicles • Reduce the life cycle costs of the vehicle and the track • Increase the energy efficiency of the system • Improve passenger comfort and the attractiveness of rail transport Specific developments are proposed the scope of ROLL2RAIL: • Basis of a radically new traction technology based on emerging electronic components leading towards more energy-efficient traction, which is lighter and more reliable while reducing the noise emitted • New wireless technology applied to train control functionalities will allow more flexible coupling to increase line capacity • Carbody solutions based on lightweight composite materials to reduce weight • A way of quantifying the life-cycle cost impact of new technological solutions for running gear; • Knowledge database of the variety of requirements in Europe for the braking systems to bring down barriers to step-change innovation in this area • Standardised methodologies for assessing attractiveness and comfort from the passenger’s point of view • Methodology for noise source separation techniques allowing implementation of novel and more efficient noise mitigation measures It is also the objective of ROLL2RAIL to serve as a preparation for a fast and smooth start up of the large scale initiative SHIFT2RAIL. All ROLL2RAIL results will ultimately lead to demonstration in real vehicles or relevant environments in SHIFT2RAIL.

Keywords: passenger perception,wireless communications and control systems,energy efficient rolling stock,light vehicles,vehicle track interaction,noise source investigation
Participatory Tools for Human Development with the Youth (PARTY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,South Africa,Switzerland,Namibia,Finland,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-02-01
End date: 2019-01-31
Duration (months): 48.0
Total project cost (EUR): 945000.0
EU funding (EUR): 945000.0
Participants: 8
Project status: CLOSED

Challenges faced by the marginalized youth in developing countries, such as unemployment, are not simple or easily solved. This is influenced by a number of factors including levels of education, gender, self-esteem, geographic location, physical ability and transport. The objective of the project is to contribute to solving the issues related to the youth unemployment in developing countries by creating participatory tools for human development that enable transformational change for the youth. Based on a service design approach, the project will provide tools for the marginalized youth suitable for daily use, enhancing regional democracy, increasing equal opportunities and contributing to human and service development with a particular target group: the San people in South Africa and Namibia. The San are faced with various social, cultural and political difficulties, and their communities are among the poorest in their countries, which are among the most unequal societies in the world. The tools aim to support the youth’s motivation and abilities to participate in the development of their own community towards a wider integration into their national socio-economic systems. The project focuses on the means and methods that assist in reaching the target group. Another objective is to cooperate with NGOs and other service providers in order to produce agile and human-centred processes and methods for developing service structures and systems towards improving the status of the marginalized youth. The third objective is to convey information on service design methods to those engaged in the development of youth services. The project aims to support the uptake of service design methods and tools in practical development work as well as the target and interest groups on a permanent basis. Thus the project establishes a strategy for continuation of the work with the target group and the local partners.

Keywords: service design,research,youth,unemployment,employability,co creation,creative industries
Improving Railway Safety Through Innovative Sensor System (Railscope)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Germany
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2018-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Senvisys is a pioneer in railway security systems. The company has developed an unprecedented train detection system based on solid-body vibration sensors. The company was founded with the purpose of increasing the railway safety. The vision of Senvisys is the 100% avoidance of casualties in train traffic. Furthermore the revolutionary technology is an enabling technology for autonomous trains. In the past, Senvisys won several renowned prices and received funding of k€500 venturing capital. For decades there has been no progress in railway security systems. Today there are around 80.000 technically unsecured railway crossings in Europe. Every year 900 casualties and severely injured people occur in Europe. Autonomous trains are in their infancy due to the lack of sensors recording obstructions or track damages reliably. Senvisys utilizes vibration sensors to ensure 100% safety of the traffic participants, railway employees and passengers because trains can be detected from a distance of 5km and continuously monitor its speed, direction and position. Railscope+ substantially reduces costs by k€200 for a level crossing. Using only 1% of the cabling used by the current technology Railscope+ has a significant environmental impact. Additionally, it can be easily implemented along the existing solutions. Thus our solution is more accurate, reliable, cost-efficient, safer and adaptable than current technologies (axis counters, wheel sensors) used in European countries. We validated the concept of our technology and ensured the demand on the European markets. In Phase 1, we intend to do a feasibility and compatibility study in which we strive to implement our technology for the potential of creating a safer Pan-European railway infrastructure. We intend to undertake several market and technology tests and work on improving the functionality and efficiency of our technology.

Keywords: railway,safety,level crossing,monitoring,train,vibration sensors,detection,environmentally friendly,efficient,economic
A cost-effective and energy-efficient water treatment technology to remove pharmaceutical pollutants from urban wastewater (DePharm)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Sweden
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-12-01
End date: 2017-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Widespread contamination from pharmaceuticals (synthetic or natural chemicals found in prescription medicines, over-the-counter therapeutic drugs & veterinary drugs) are finding their way into the drinking water supply, posing serious threats to public health. Pharmaceutical compounds such as hormones and endocrine disrupters are already responsible of major health problems, but modern wastewater treatment systems are not designed for effective removal of pharmaceuticals. Pharem Biotech brings to market the first enzyme-carrying filtration system able to remove a large range of organic pollutants (pharmaceuticals and other biological active compounds such as Bisphenol A, PFOS, antibiotics, hormone disruptors, etc.) in wastewater treatment plants, without additional energy requirement. By combining the enzymes with biotechnological techniques and a process for applying the enzymes onto a physical filter, the solution provides a wastewater treatment process step that can be added onto the existing water treatment processes at sewage treatment plants and work without external energy. The solution is based on modified enzymes which are 200 times more effective than native enzymes, resistant to low temperature, resistant to low pH and with high levels of stability and activity. The solution was successfully demonstrated in an industrial environment (Hammarby Sjöstadsverk in Stockholm, Sweden, a test and demonstration facility for innovative waste water purification run by the Swedish Environmental Institute) where it effectively removed the pharmaceutical and other organic pollutants from urban wastewater at a price that is 10X lower than alternative solutions. Pharem aims to equip 50 WWTPs by 2020, for a turnover of €30M+.

Keywords: wastewater,water treatment,wwtp,pharmaceuticals
ECOlogical building enveLOPES: a game-changing design approach for regenerative urban ecosystems (ECOLOPES)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Israel,Germany,Spain,Germany
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-04-01
End date: 2025-03-31
Duration (months): 48.0
Total project cost (EUR): 2999383.75
EU funding (EUR): 2999383.75
Participants: 7
Project status: SIGNED

Urbanisation constitutes a major environmental issue of the 21st century. Within cities, densification, the decrease of green open spaces, and a continued reliance on grey infrastructures result in increasing separation of people from nature and decrease access to ecosystem services. This decreases the liveability of cities and reduces human well-being. Current approaches fall short in providing breakthrough solutions, because they perpetuate the human-nature dichotomy due to anthropocentric design. We propose a radical change for city development: instead of minimizing the negative impact of urbanisation on nature, we aim at urbanisation to be planned and designed such that nature – including humans - can co-evolve within the city. This vision requires a radically new integrated ecosystem approach to architecture that focuses equally on humans, plants, animals, and associated organisms such as microbiota. In ECOLOPES, we propose to develop the technology that will allow to achieve this vision. We will focus on the envelope, the building enclosure. In ECOLOPES, we transform the envelope into an ecolope, a multi-species living space for four types of inhabitants, humans, plants, animals, and microbiota. ECOLOPES will develop the core technologies for designing ecolopes in a systematic way, considering the needs of all habitants. ECOLOPES will make biological knowledge available for the architectural design process, to find architectural solutions that enable synergies and limit conflicts between the inhabitants. The ecolopes designed by this multi-species approach will restore the beneficial human - nature relationships in cities. Key products of ECOLOPES are: (1) ECOLOPES Information Model Ontology that integrates ecological and architectural knowledge, data and models into a data-integrated design recommendation system; (2) ECOLOPES Computational modelling and simulation environment, that is based on the EIM Ontology, to make knowledge available for design.

Keywords: computational design,landscape architecture,urban ecology,urban planning,animal ecology,microbiomes,human nature interaction,urban greening
Realising the Transition to the Circular Economy: Models, Methods and Applications (ReTraCE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: South Africa,Germany,Italy,Germany,Germany,Spain,Italy,Italy,Belgium,Sweden,China,Korea, Republic of,Greece,Greece,France,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2018-11-01
End date: 2023-04-30
Duration (months): 54.0
Total project cost (EUR): 4039862.04
EU funding (EUR): 4039862.04
Participants: 30
Project status: SIGNED

This network brings together an exceptionally strong team of world-leading experts from a wide set of beneficiaries and partners in order to achieve breakthroughs in understanding how the transition towards a Circular Economy (CE) can be realised in a successful way in the European context, both within existing organisations and industries as well as through innovative and sustainable business models. The proposed approach is inherently multi-disciplinary, drawing upon research that will advance significantly the state-of-the-art in terms of the current understanding of the applicability of the CE paradigm from Economic, Environmental and Social points of view, providing policy insights and implications for practice. The consortium of 10 beneficiaries (including 7 academic and 3 non-academic groups) will design and deliver world class multidisciplinary training to 15 Early Stage Researchers (ESRs), offering them an extended and valuable program of international exchanges and secondments through the wide network of partner organisations involved in the proposal. The network builds on the success of previous projects in which beneficiaries have successfully delivered high impact research and knowledge exchange. ReTraCE is specifically designed to train a cohort of new thought leaders capable of driving the transition towards a more sustainable mode of production and consumption in Europe in the next decades, who will directly facilitate the implementation of the recently adopted ambitious Circular Economy strategy of the European Commission, which is closely linked to Sustainable Development Goals (SDGs). Indeed, it is envisaged that ESRs will be employable not only by research institutions, but also by public sector bodies and within a wide range of manufacturing and service industries which will require new professional profiles for realising the transition towards the CE.

Keywords: circular economy,transition,sustainable supply chains,industrial ecology,sustainable,development,closed loop supply chains,life cycle analysis,sustainable business models
The Holy Roman Empire of the German Nation and its Slaves (GermanSlavery)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-08-01
End date: 2022-01-31
Duration (months): 78.0
Total project cost (EUR): 1939111.0
EU funding (EUR): 1939111.0
Participants: 1
Project status: CLOSED

The proposed project analyses slavery in the Holy Roman Empire of the German Nation in the long 18th century.

Keywords: slavery,germany
Age-Selective Segregation of Organelles (Age Asymmetry)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Finland
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2021-04-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Our tissues are constantly renewed by stem cells. Over time, stem cells accumulate cellular damage that will compromise renewal and results in aging. As stem cells can divide asymmetrically, segregation of harmful factors to the differentiating daughter cell could be one possible mechanism for slowing damage accumulation in the stem cell. However, current evidence for such mechanisms comes mainly from analogous findings in yeast, and studies have concentrated only on few types of cellular damage. I hypothesize that the chronological age of a subcellular component is a proxy for all the damage it has sustained. In order to secure regeneration, mammalian stem cells may therefore specifically sort old cellular material asymmetrically. To study this, I have developed a novel strategy and tools to address the age-selective segregation of any protein in stem cell division. Using this approach, I have already discovered that stem-like cells of the human mammary epithelium indeed apportion chronologically old mitochondria asymmetrically in cell division, and enrich old mitochondria to the differentiating daughter cell. We will investigate the mechanisms underlying this novel phenomenon, and its relevance for mammalian aging. We will first identify how old and young mitochondria differ, and how stem cells recognize them to facilitate the asymmetric segregation. Next, we will analyze the extent of asymmetric age-selective segregation by targeting several other subcellular compartments in a stem cell division. Finally, we will determine whether the discovered age-selective segregation is a general property of stem cell in vivo, and it's functional relevance for maintenance of stem cells and tissue regeneration. Our discoveries may open new possibilities to target aging associated functional decline by induction of asymmetric age-selective organelle segregation.

Keywords: asymmetric cell division