Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
European Industrial Doctorate in future efficient minerals analysis, processing and training (MetalIntelligence)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Ireland,Ireland,Sweden,Finland,Finland,Finland,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2016-09-01
End date: 2020-08-31
Duration (months): 48.0
Total project cost (EUR): 1596958.56
EU funding (EUR): 1596958.56
Participants: 9
Project status: CLOSED

MetalIntelligence proposes an EID in future efficient minerals analysis, processing and training. Transformational change caused by the third industrial revolution, which itself relies on extraction of raw materials, provides the impetus. A resource-efficient EU is recognised as a societal challenge. However, the pathway from searching for mineral deposits to metal production is complex and involves a number of sectors (geosciences, chemical analysts, mining, processing, metallurgy) that have tended to work in silos. Limited intersectoral collaboration has led to compartmentalised thinking which has become an impediment to improved resource and energy efficiency. The overall aim of MetalIntelligence is to disrupt this compartmentalisation, by training 6 ESRs through a multi-disciplinary network of academic and industry leaders with an exceptionally broad range of expertise and skills. The team comprises three beneficiaries (2 academic, in Ireland and Sweden, and one Industry, Finland) as well as 4 partners (from the UK, Ireland, and Finland) who will provide secondment opportunities and/or industrial supervision. The programme is arranged as work packages (WPs), including management, training, and dissemination as well as three research-driven packages. The first research-based WP aims to improve mineral analysis in preparation for more efficient processing. The second concerns itself with advanced modelling of dynamic minerals processing. The third will research modern, technology-enhanced training for future professionals. The tailor-made training programme consists of network wide components, delivered by industry and academia leaders as well as specific training in the workplace. The objectives of MetalIntelligence were designed to align with European innovation capacity policies and the network will contribute to keeping the industries competitive by developing innovative, more gender-balanced human capital for the raw materials sector in Europe.

Keywords: mineral resources,efficient minerals processing,chemical analysis,particle liberation,digital learning
A Multiscale Dislocation Language for Data-Driven Materials Science (MuDiLingo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany,Germany,France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-11-01
End date: 2023-10-31
Duration (months): 72.0
Total project cost (EUR): 1499145.0
EU funding (EUR): 644584.43
Participants: 3
Project status: SIGNED

Crystalline defects in metals and semiconductors are responsible for a wide range of mechanical, optical and electronic properties. Controlling the evolution of dislocations, i.e. line-like defects and the carrier of plastic deformation, interacting both among themselves and with other microstructure elements allows tailoring material behaviors on the micro and nanoscale. This is essential for rational design approaches towards next generation materials with superior mechanical properties. For nearly a century, materials scientists have been seeking to understand how dislocation systems evolve. In-situ microscopy now reveals complex dislocation networks in great detail. However, without a sufficiently versatile and general methodology for extracting, assembling and compressing dislocation-related information the analysis of such data often stays at the level of “looking at images” to identify mechanisms or structures. Simulations are increasingly capable of predicting the evolution of dislocations in full detail. Yet, direct comparison, automated analysis or even data transfer between small scale plasticity experiments and simulations is impossible, and a large amount of data cannot be reused. The vision of MuDiLingo is to develop and establish for the first time a Unifying Multiscale Language of Dislocation Microstructures. Bearing analogy to audio data conversion into MP3, this description of dislocations uses statistical methods to determine data compression while preserving the relevant physics. It allows for a completely new type of high-throughput data mining and analysis, tailored to the specifics of dislocation systems. This revolutionary data-driven approach links models and experiments on different length scales thereby guaranteeing true interoperability of simulation and experiment. The application to technologically relevant materials will answer fundamental scientific questions and guide towards design of superior structural and functional materials.

Keywords: computational materials science,small scale plasticity,machine learning,data driven materials science,dislocations,microstructure property relation
Implementation of a smart RETROfitting framework in the process industry towards its operation with variable, biobased and circular FEEDstock (RETROFEED)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Innovation actions
Countries involved: Spain,Spain,Italy,Italy,Italy,Spain,Italy,Italy,Spain,Türkiye,Romania,Poland,Sweden,Belgium,Türkiye,Hungary,Czechia,Portugal
Call: Adaptation to variable feedstock through retrofitting (IA 50%) (H2020-NMBP-SPIRE-2019, 2019)
Start date: 2019-11-01
End date: 2023-10-31
Duration (months): 48.0
Total project cost (EUR): 15645076.88
EU funding (EUR): 9912915.33
Participants: 19
Project status: SIGNED

RETROFEED main objective is to enable the use of an increasingly variable, bio-based and circular feedstock in process industries through the retrofitting of core equipment and the implementation of an advanced monitoring and control system, and providing support to the plant operators by means of a DSS covering the production chain. This approach will be demonstrated in five resource and energy intensive sectors (ceramic, cement, aluminium, steel, and agrochemical) with the potential to reach in average an increase of 22% in resource efficiency and 19% in energy efficiency, with a consequent reduction in costs and GHG emissions of 9.3 M€ and 135 kton CO2 respectively. Furthermore, the project aims to develop a methodology to support retrofitting in resource and energy intensive industries that will be complemented by a decision support system able to perform a diagnosis of the impact in the process of different retrofitting solutions so plant managers and operators can decide on the most suitable retrofitting action for their companies. This decision support system will remain operative after the modification of the process so it can ease the operation of the process under the increased variability of feedstock by analysing a set of key indicators defined within RETROFEED over the production chain for this purpose. RETROFEED consortium comprises strong industrial participation; 9 large companies, including 5 of them as final users, and 4 SMEs as technology providers, working with experienced RTOs and supporting entities. The private investment associated to RETROFEED is over 7M€ along the execution of the project. Lastly, RETROFEED is expected not only to enable technological advances in the technologies and demonstrators involved but will also contribute to the development of new standards, regulations, training programmes, and adaptation and certification of industrial processes thus facilitating the replication of the project results within the EU industry.

Keywords: industrial processes retrofitting,energy and resource efficiency,circular economy,bioeconomy,advanced modelling and simulation,monitoring and control systems
Language contact and negation in indigenous South America (LACONN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-04-07
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: SIGNED

Negation is a universal feature of a human language. Each language has the linguistic means to express the denial (negation) of a proposition. While specific realizations differ to a certain extent, languages show a very clear cross-linguistic tendency in the position (and nature) of a negative marker: it tends to be a free-standing element and occur before the verbal predicate. Different from most languages, indigenous languages of the South American continent show a typologically unusual – as yet unexplained – behaviour, in that a negative marker tends to occur after the verbal predicate and often as a suffixal element. The scientific aim of this project is to provide an informed answer on the role of language contact behind the continent-wide presence of the postverbal pattern, which distinguishes South American (SA) languages from most others. With reaching this aim, the action will make an impact in two ways: (i) it will bring in a piece of linguistic evidence contributing to a better understanding of SA prehistory, which still has many open questions, and (ii) it will enrich theoretical models of language evolution by providing an account as to how a functionally dispreferred pattern gets maintained in a language. I plan to carry out this project under supervision and in collaboration with Rik van Gijn, whose ERC Consolidator project on ‘South American Population History Revisited: Multidisciplinary perspectives on the Upper Amazon’ (SAPHIRE), hosted at the Leiden University Centre for Linguistics (LUCL), is of key relevance to the proposed action. Thus, I will enrich my research profile, which combines typology and diachrony of morpho-syntax with a solid expertise in contact linguistics and experience in interdisciplinary approach to linguistic data. From the professional career perspective, the Fellowship will help me gain academic independence and will ultimately serve as a springboard for a tenured research position.

Keywords: language contact,language change,negation,typology,indigenous languages
Tools and TECHNOlogies for Breakthrough in hEArt Therapies (TECHNOBEAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Israel,Germany,Belgium,Netherlands,Netherlands,United Kingdom
Call: Tools and technologies for advanced therapies (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 5968850.0
EU funding (EUR): 5968850.0
Participants: 8
Project status: CLOSED

Cardiovascular diseases including myocardial infarction (MI), which entails the irreversible loss of heart muscle tissue, constitute a major socio-economic burden in global healthcare. With whole organ transplantation as the only treatment option for end-stage heart failure, MI patients could particularly benefit from advanced cell therapies aimed at the functional reconstitution of damaged hearts. Human induced pluripotent stem cells (hiPSCs) can be derived by reprogramming patients’ somatic cells. In contrast to adult (stem) cells e.g. from blood, bone marrow or the heart, hiPSCs have unlimited expandability and differentiation potential into all relevant cell types including cardiomyocytes, endothelial cells, pericytes and connective tissue-forming cells, making them highly attractive as a universal cell source for organ repair. However, technologies for the robust therapeutic scale production of hiPSC-derived progenies in line with GMP standards and at reasonable cost are currently lacking. TECHNOBEAT’s ultimate objectives are 1) to advance therapeutic scale cell production through innovative bioreactor technologies and novel cell monitoring tools, and 2) to develop regulatory compliant bioprocessing of innovative iPSC-based cardiac µ-tissue. The clinical translation of cardiac µ-tissue will require 3) the development and application of tools for improved cell delivery and longitudinal in vivo monitoring of cell grafts, and 4) proof-of-concept for safety and functional integration in physiologically relevant preclinical models of cellular heart repair. Through its interdisciplinary excellence, TECHNOBEAT’s consortium of leading European stem cell researchers, clinicians, tissue-, bioprocess-, and technical- engineers in industry and academia is ideally positioned to address these ambitious objectives. It will provide new treatment options for suffering patients and increase Europe’s attractiveness as a hub for innovative medical technologies.

Keywords: myocardial infarction,cell therapy,hipsc,cardiomyocytes,bioreactor,tissue engineering,animal models,catheter,reporter gene,holographic microscopy,clinical compliance,spect ct imaging
Dynamical Redesign of Biomolecular Networks (BioNet)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-02-01
End date: 2024-01-31
Duration (months): 72.0
Total project cost (EUR): 1499999.0
EU funding (EUR): 968817.5
Participants: 2
Project status: SIGNED

Enzymes created by Nature are still more selective and can be orders of magnitude more efficient than man-made catalysts, in spite of recent advances in the design of de novo catalysts and in enzyme redesign. The optimal engineering of either small molecular or of complex biological catalysts requires both (i) accurate quantitative computational methods capable of a priori assessing catalytic efficiency, and (ii) molecular design principles and corresponding algorithms to achieve, understand and control biomolecular catalytic function and mechanisms. Presently, the computational design of biocatalysts is challenging due to the need for accurate yet computationally-intensive quantum mechanical calculations of bond formation and cleavage, as well as to the requirement for proper statistical sampling over very many degrees of freedom. Pioneering enhanced sampling and analysis methods have been developed to address crucial challenges bridging the gap between the available simulation length and the biologically relevant timescales. However, biased simulations do not generally permit the direct calculation of kinetic information. Recently, I and others pioneered simulation tools that can enable not only accurate calculations of free energies, but also of the intrinsic molecular kinetics and the underlying reaction mechanisms as well. I propose to develop more robust, automatic, and system-tailored sampling algorithms that are optimal in each case. I will use our kinetics-based methods to develop a novel theoretical framework to address catalytic efficiency and to establish molecular design principles to key design problems for new bio-inspired nanocatalysts, and to identify and characterize small molecule modulators of enzyme activity. This is a highly interdisciplinary project that will enable fundamental advances in molecular simulations and will unveil the physical principles that will lead to design and control of catalysis with Nature-like efficiency.

Keywords: enhanced sampling alogrithms,free energy calculations,phosphate catalysis
Development of new immunoassays for the diagnosis and prediction of drug-related complement pathology (immunoassays)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

Infusion reactions (IRs) are complex, immune-mediated side effects, also known as hypersensitivity reactions (HSRs), that can occur upon intravenous infusion of pharmaceuticals, leading to severe and sometimes life-threatening conditions in patients. Those reactions may arise from a real allergy which is immune globulin class E (IgE) mediated or a “pseudoallergy”. The latter involves no IgEs and may arise because of activation of the complement (C) system called C activation-related pseudoallergy (CARPA). The complement (C-) system is part of the immune system called the innate immune system that is not adaptable and responds to foreign challenges in a non-specific manner. When stimulated proteases of the complement system cleave other C proteins and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is a massive acute inflammatory response caused by the release of cytokines, anaphylatoxins and the cell-killing membrane attack complex (MAC). Products triggering severe adverse events can include both traditional small molecules but also biologics such as therapeutic antibodies (Abs), fusion proteins, etc. and novel formulations using liposomes or nanotechnology. Regulatory guidance on the assessment of C-mediated infusion hypersensitivity has been published recently for the case of generic liposome production. Hemocompatibility (blood safety) testing for medical devices is requested by EMA and FDA since many years. However, regarding the potential of new pharmaceuticals causing allergies and/or CARPA remains a significant challenge for the industry during nonclinical development as no established safety biomarker nor meaningful, validated animal models are available up to date. During the project “IMMUNOASSAYS” Dr Fülöp proposes the development and quantitative evaluation of three promising specific safety biomarkers via ELISA technology.

Keywords: in vitro testing,trials
Regulation of red cell life-span, erythropoiesis, survival, senescence and clearance (RELEVANCE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Italy,Germany,Spain,Germany,Germany,Switzerland,France,Netherlands,Netherlands,United Kingdom,Denmark,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2015-09-01
End date: 2019-11-30
Duration (months): 51.0
Total project cost (EUR): 3852126.97
EU funding (EUR): 3852126.9699999997
Participants: 16
Project status: CLOSED

Anaemia is the most common pathological condition affecting 1.6 billion individuals worldwide. It thus presents a serious health care problem and an economic burden. Reduction in red blood cell (RBC) number can be caused by blood loss, diet, stress conditions including endurance sport, and pathologies which are caused by primary genetic aberrations or are secondary to the malfunction of other cell types. Transfusion of RBC, which is often the only cure for severe cases of anaemia, is associated with risks such as thrombosis and transfusion reactions due to allo-immunisation. There is an unmet need to improve treatment of anaemia through early and accurate diagnosis, targeted treatment, and increased safety and effectiveness of RBC transfusion. The aim of RELEVANCE is to improve fast and cost-effective diagnosis of the underlying cause of primary anaemia, and to improve treatment options for both general and personalised medicine. We defined five key objectives: (1) to improve diagnostics of anaemia, particularly for hereditary rare forms of anaemia (RA); (2) to find novel treatments for anaemia that target RBC production, ageing and clearance; (3) to reduce premature loss of RBC following transfusion; (4) to produce cultured RBC for transfusion; (5) to monitor and optimise RBC function during sport and exercise. RELEVANCE will train 15 early stage researchers (ESR) at four SMEs and eight academic partners, two of whom are at blood supply centres and two are diagnostic centres for RA. The continuous interactions between the clinic, blood supply centers, basic research, and industry will select for the most relevant unmet medical needs, and will stimulate innovative procedures that are immediately probed for applicability and validity both in a research and a clinical setting. RELEVANCE will organize three open access summer schools, extending training beyond the ESR of the ITN sustaining the critical number of young talented professionals in the field.

Keywords: erythrocytes,haematopoiesis,life cycle,membrane transport,cellular imaging,stem cell,differentiation,drug screening,microfluidics,image analysis,next generation sequencing