Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Unlocking the effect of residual elements via the NANOengineering of Sustainable MARTensitic steels (NANO-S-MART)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Clean Steel (co-programmed)
Countries involved: Spain,Belgium,Germany
Call: CO2-neutral steel production with hydrogen, secondary carbon carriers and electricity OR innovative steel applications for low CO2 emissions (Clean Steel Partnership) (RIA) (HORIZON-CL4-2024-TWIN-TRANSITION-01, 2024)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 3079420.0
EU funding (EUR): 3079420.0
Participants: 5
Project status: SIGNED

The European steel industry is at a critical juncture, squeezed between brutal market conditions and the commitment to mitigate climate change. The iron and steel industry is responsible for high greenhouse gas emissions, particularly carbon dioxide (CO2), constituting 5.7% of the total emissions in the EU (2.2 tonnes CO2 per tonne of crude steel cast, refer to World Steel data). Several European steel producers (including ArcelorMittal) have committed to fulfilling the goals outlined in the Paris Agreement and aligning with the European Union's target of achieving zero emissions by 2050, as part of the Green Deal initiative. These engagements entail a shift from the predominant method of steel production, currently reliant on blast furnace/basic oxygen furnace (BF/BOF) technology, to cleaner production techniques characterized by significantly lower CO2 emissions. As the industry shifts toward cleaner production methods, particularly those utilizing electric-arc furnaces (EAF) and emphasizing the recycling of iron scrap, concerns arise about the potential contamination of steel with residual elements like Cu, Sn, As, Sb, and P. The NANO-S-MART project emerges as a response to this pressing need, focusing on the systematic and in-depth analysis of the impact of residual elements in martensitic steels. Martensitic steels, vital across key sectors such as construction, automotive, energy, and defense, play a pivotal role in the EU's efforts to achieve climate neutrality and increase renewable energy usage. The project addresses macro, micro, and nano-scale considerations, encompassing the entire steel production process. NANO-S-MART project aims to provide clear guidelines for redesigning grades and validating technologies in relevant environments. By bridging knowledge gaps and embracing cutting-edge technologies, NANO-S-MART endeavors to revolutionize martensitic steel production, contributing to a sustainable and circular economy in the EU.

Keywords: residuals,eaf,martensitic steels,processability,apt,in situ sem microcompression,diffusion modelling,hot ductility,mechanical properties,phase transformation,tem,nano segregation,lca
Sifting through the 3D Genome: Computational Models of Homology Search in DNA Repair (3DGenomeSearch)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Homology-directed repair is an essential, evolutionary conserved DNA repair pathway that accurately restores genetic information lost due to double-stranded breaks. Its key step is the ‘homology search’, where the broken DNA end locates its matching sequence, typically located on a sister chromatid, to use as a repair template. Despite its significance, the biophysical mechanism of this search within the complex environment of vertebrate genomes remains debated. Emerging hypotheses propose that this search is driven by ‘nucleoprotein’ filaments comprised of repair proteins bound to the broken DNA ends, that actively traverse the nuclear space to find and recognize homologous sequences. We will explore this mechanism by developing quantitative biophysical models that integrate the latest experimental insights on the 3D architecture of sister chromatids and dynamics of nucleoprotein filaments. Our specific aims are: (1) Model the homology search in 3D to understand how broken DNA sites navigate the complex nuclear environment and identify homologous sequences on intricately folded vertebrate sister chromatids. (2) Explore the microscopic mechanisms that drive the large-scale motions and efficient homology search by nucleoprotein filaments. (3) Understand the role of filament-driven homology search in the pairing of homologous chromosomes during meiosis. By integrating these complementary aims, we will build a detailed biophysical, mechanistic picture of homology search. We will calibrate our models against genomic and microscopic datasets, and test their predictions in collaborations with several experimental biology groups. This modeling will provide mechanistic insights into homology search, rigorously test long-standing hypotheses, and generate predictions to guide future experiments. The proposed research will significantly advance our understanding of this key DNA repair process and its potential roles in maintaining genome stability and meiotic recombination.

Keywords: chromosome conformation,hi c,biophysical modeling,polymer physics
U-space Air and Ground Risk modEls Enhancement (U-AGREE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Spain,Belgium,Italy,Germany,Ireland,United Kingdom
Call: ATM Excellent science and outreach for for U-space and urban air mobility (HORIZON-SESAR-2023-DES-ER-02, 2023)
Start date: 2024-09-01
End date: 2027-02-28
Duration (months): 30.0
Total project cost (EUR): 1018053.75
EU funding (EUR): 953553.75
Participants: 10
Project status: SIGNED

U-AGREE aims to develop an integrated risk model linking the operations of unmanned aircraft (UAS) with some negative effects they may have with regard safety, security, privacy and environment. This risk model is intended to support the airspace risk assessments required by U-space European regulation as well as an amendment to SORA methodology so that risk can be quantitatively estimated, enabling digital implementations leading to swifter operational approval processes. Moreover, the U-AGREE risk model will account for U-space services to mitigate the risk, thus reducing the burden of meeting the SORA operational safety objectives and unleashing operations and business models which are currently economically unviable. To achieve these goals, U-AGREE will start by identifying realistic scenarios where UAS operations will take place and will assess them to identify all the hazards that these operations can pose to safety, security, privacy and environment. Next, the project will agree metrics and thresholds to measure the risk due to these hazards with relevant stakeholders (especially civil aviation authorities and common information services providers). Afterwards, the team will develop mathematical models linking the hazards with their effects (either on the ground or in the air) and will define mitigation barriers using U-space services, as well as algorithms to quantify their effectiveness in terms of risk ratios. These models will be integrated into state-of-the-art U-space simulators to evaluate the applicability and relevance of the proposed integrated risk model in the representative scenarios previously identified by the project. To synchronise the project outcomes with the U-space deployment, a first version of the risk model addressing short term needs will be delivered one year after the project kick-off, whereas a second version addressing mid to long-term needs (e.g., urban air mobility or variable demand) will be delivered at the end of the project.

Keywords: air risk model,ground risk model,sora,u space,uas
Advanced biodiversity monitoring for results-based and effective agricultural policy and transformation (BioMonitor4CAP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Portugal,Germany,Bulgaria,Finland,Czechia,Poland,Peru,United Kingdom,Belgium,Netherlands,Austria
Call: Monitoring and effective measures for agrobiodiversity (HORIZON-CL6-2022-BIODIV-01, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 6953352.52
EU funding (EUR): 6953352.52
Participants: 26
Project status: SIGNED

Unsustainable agricultural practices are major drivers affecting habitat and species diversity in agricultural landscapes of the EU. However, peatland, grassland, and species associated with agriculture are of most concern. The ongoing negative impacts of unsustainable agricultural practices emphasize the need for a fully integrated approach between the EU 2030 Biodiversity and Farm to Fork Strategies. Supporting the EC`s ambition of enhancing biodiversity of agricultural landscapes advanced systems are required to monitor biodiversity features and their changes over time and in space. Such biodiversity monitoring systems will support implementation of result-based policies in the European agricultural landscapes. The BioMonitor4CAP project will design advanced biodiversity monitoring systems mainly assessing diversity of targeted species and habitats to be tested, calibrated, and demonstrated in five European regions representing the major agro-ecological regions of the EU and one region in Peru representing one of the global biodiversity hot spots. The project will combine classical indicator systems that are part of the European monitoring framework (e.g. Farmland Bird Index) with various indicator systems mostly recently developed and applied in form of standalone systems: i) new indicator species (e.g. grasshopper), ii) genetic diversity (eDNA), iii) on-site sensors (e.g. wing beat frequency, acoustic sounds), iv) functional diversity (e.g. pollinators), and iv) various spatial measures. Supporting development and implementation of revised agricultural policies and ensuring rural development the project will involve among multiple stakeholder groups particularly farmers, conservationists, and service provides as the value and/or marketability of public and/or private goods delivered through maintained and enhanced biodiversity and related monitoring systems are hardly understood.

Keywords: agriculture,grassland,agroforestry,birds,insects,soil,nature 2000,acoustics,optical,spectroscopic
An ecological framework to advance crop diversification in southern Africa (EcoDiv)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden,Mexico
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-06
End date: 2026-06-05
Duration (months): 39.0
Total project cost (EUR): 277291.2
EU funding (EUR): 277291.2
Participants: 2
Project status: SIGNED

Crop diversification offers substantial potential benefits for smallholder farmers in southern Africa. Positive interactions between diverse crops can lead to higher and more stable yields, more nutritious diets, better economic returns, and lower agrichemical use. However, choosing the right diversification option to realise these benefits is challenging. Interactions between crops can be negative as well as positive, and it is not yet well understood which features of different crop combinations and their environments determine their overall performance. EcoDiv will address this knowledge gap by undertaking an ambitious analysis of large datasets from agricultural field experiments across Zimbabwe, Zambia and Malawi. Specifically, EcoDiv will 1) quantify the relationships between crop combination productivity and crop traits under different environmental conditions, 2) explore which characteristics of crop combinations are important to meet different socioeconomic needs, and 3) investigate whether the effects of crop combinations on microhabitat conditions explain their performance. This research will produce an ecological framework for crop diversification in southern Africa: an understanding of the key interactions between crop traits and environmental conditions that predict the performance of different crop combinations in different contexts. To achieve EcoDiv’s objectives, Dr Chloe MacLaren (the research fellow) will work with interdisciplinary and international research teams at two host institutes, the Swedish University of Agricultural Sciences (SLU) and the International Maize and Wheat Improvement Centre (CIMMYT). EcoDiv will advance Dr MacLaren’s career by developing the knowledge, skills, and networks needed to achieve leading research positions in ecology for agricultural development. Both hosts will benefit from transfer-of-knowledge in new statistical methods, and from strengthened collaboration around shared research goals in sub-Saharan Africa.

Keywords: crop diversity,sustainable intensification
City-oriented Impacts of Regional Climate for Europe (CIRCE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-07-01
End date: 2025-06-30
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

Extreme weather events are already affecting urban areas with sometimes severe impacts on people, infrastructure and socio-economic activities. Faced with these effects, which are expected to increase due to climate change, decision-makers need sound climate information on local urban issues in order to better plan the cities of tomorrow. Today, climate change impacts on urban areas are assessed by separate scientific communities, with some methodological limitations for each approach: Regional Climate Models (RCM) provide climate change information at the regional scale, but with a coarse horizontal resolution for cities and without specific surface parameterisation for urban processes; most high-resolution impact studies focusing on urban issues (energy, thermal comfort) do not take into account urban-regional climate interactions and are city and indicator dependent. The CIRCE project aims to develop a more robust and generic methodology for assessing the impacts of climate change on European cities by (1) identifying innovative impact indicators that are relevant for local decision-makers and can be calculated from modelled and available city data and (2) clarifying the best current regional climate modelling configurations for urban impact studies. To this end, the new generation of high-resolution Convective-Permitting Models (CPM) will be used for the first time in a multi-city ensemble approach. Multi-sectoral indicators will be defined based on local climate risks (with a focus on heat waves and extreme precipitation) and urban issues related to various European cities. The ability of climate models to simulate specific extreme climate events and their impacts on cities will be assessed. Then, their future evolution will be analysed by combining the largest set of RCMs and CPMs currently available. The final objective will be to co-develop an urban climate service demonstrator based on these results and to feed into the CORDEX Flagship Pilot Study URB-RCC.

Keywords: extreme weather events,heat wave,heavy precipitation events,regional climate model,convection permitting model,urban impact study,urban climate service
UNMANNED VEHICLES FOR CIVIL SECURITY AND SURVEILLANCE MISSIONS (PROACTIF)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: Finland,Latvia,Hungary,Poland,Germany,Netherlands,Austria,Spain,Israel,Belgium,France,Italy,Switzerland
Call: Topic 1 Global call according to SRIA 2024 (HORIZON-JU-Chips-2024-1-IA, 2024)
Start date: 2025-05-01
End date: 2028-04-30
Duration (months): 36.0
Total project cost (EUR): 41821140.25
EU funding (EUR): 11547260.03
Participants: 46
Project status: SIGNED

PROACTIF develops unmanned vehicles based framework for civil security, combining cutting edge UxVs, sensors, components, mission control and multi-domain teaming for safe and secure surveillance of critical infrastructures and for efficient management of emergency situations. The project concept is based on R&D in three technology domains (TDs): TD1 is dedicated to UXV perception capabilities, enabling an unmanned vehicle to observe the surrounding world, including e.g. radars, LiDARs and antennas, as well as IR, hyperspectral and electromagnetic sensing, and edge-could managing of related data. TD2 will focus in UXV mission management, enabling command and control, connectivity, location and positioning, cybersecurity and teaming needed for the complex operations by unmanned vehicles, also paving the way to autonomic vehicles. TD3 will focus in developing of 5 UxV platform capabilities; UAV, USV and 3 different UGVs. All the technology building blocks developed in TD1 and TD2 will be demonstrated both individually and on TD3 platforms in relevant civil security missions. The mission cases represent the different security needs of the civil society, including offshore, seaports, rail yards, energy substations, emergency sites, wildfires, search and rescue and crowd monitoring and teamed UxV operation. The results provide focused contributions to the SRIA 2024 topics. PROACTIF aims to ensure that Europe is well prepared for the whole range of different security challenges and emergency situations, with the aid of technologies that will be available in different geopolitical situations - technologies whose ownership and manufacturing capabilities are in Europe. The consortium includes 42 partners from 13 different countries: 18 SMEs, 11 LEs and 13 RTOs, covering the value chain from electronics packaging to sensors and components, data management, AI and cybersecurity, to UXV platforms to integrate them, and end users. The total budget is 42 M€.

Keywords: security,civil,unmanned,uav,usv,ugv,sensors,connectivity,ai ml,system of systems,cybersecurity
Epromoters in health and disease (Eprom)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2024-12-31
Duration (months): 29.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: CLOSED

Promoters and enhancers regulate transcription in higher eukaryotes. The classical definition of enhancers is the property to activate gene expression distally, while promoters induce local gene expression. However, itPromoters and enhancers regulate transcription in higher eukaryotes. The classical definition of enhancers is the property to activate gene expression distally, while promoters induce local gene expression. However, it was demonstrated that a subset of promoters, termed Epromoters, also work as bona fide enhancers and regulate distal gene expression. Moreover, it was shown that human single nucleotide polymorphisms (SNP) within Epromoters can influence their function, and consequently distal and proximal gene expression of their target genes. We hypothesise that Epromoters might have an unanticipated key role in coordinating gene expression in disease as well. In this project, I will develop a dual reporter assay to investigate the enhancer versus promoter function of candidate regions, in order to identify novel Epromoters. Subsequently, selecting candidate Epromoters predicted by a previously developed bioinformatics pipeline, I will use the reporter assay to test the candidates in a high-throughput manner. Moreover, I will select those validated Epromoters that contain human disease associated SNPs using genome-wide association studies databases. Next, to determine which of these disease-associated SNPs have an impact on gene expression through Epromoter function, distally regulated genes will be inferred by genome editing of the identified SNPs in relevant cell lines. Concluding, I will study the biology of Epromoters by i) analysing their function in physiological context, ii) assessing the impact of overlapping genetic variants, and iii) determining the effect of disease-associated SNPs on Epromoters and their target gene expression, thus providing a valuable resource to understand Epromoters and their potential involvement in different diseases.

Keywords: enhancer,promoter,epigenetics,gwas