Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
C-H Acids for Organic Synthesis (CHAOS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2021-09-30
Duration (months): 60.0
Total project cost (EUR): 2007500.0
EU funding (EUR): 2007500.0
Participants: 1
Project status: CLOSED

Enantioselective Brønsted acid organocatalysis has the potential to revolutionize asymmetric synthesis. However, the commonly used chiral phosphoric acid catalysts are typically limited to certain, fairly reactive substrate classes such as imines. Recently, more active and stereoselective catalysts have been introduced, which rely on acidic N–H bonds, and which have significantly widened the scope of suitable substrates. Despite the considerable success of these catalysts, however, several important and highly attractive substrate classes still remain out of reach. The applicant’s group has now identified C–H acids as novel and highly promising candidates to tackle these long standing challenges. Here, a research program with three major goals is proposed: 1) broadly conceived synthetic studies will be undertaken, which are expected to give access to C–H acids with a wide range of acidity and steric confinement. 2) These C–H acids will be applied to address one of the most general limitations currently encountered in organocatalysis: The enantioselective conversion of small and unbiased substrates. 3) The developed C–H acids, which are expected to enable unprecedented acidities and catalytic activities, will be employed in the activation of increasingly less reactive electrophiles, for example aliphatic aldehydes but also esters and olefins, for which enantioselective organocatalytic reactions are currently very limited or even unknown. Overall, this research program will aim at the design, synthesis and application of C–H acids as platform for solving several long standing challenges in asymmetric organocatalysis. The introduction of C–H acids for organic synthesis is expected to enrich the toolbox of synthetic chemists in both academic and industrial laboratories.

Keywords: organocatalysis,asymmetric counteranion directed catalysis,enantioselective catalysis
CLEVER Cities - Co-designing Locally tailored Ecological solutions for Value added, socially inclusivE Regeneration in Cities (CLEVER Cities)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Innovation actions
Countries involved: Austria,Italy,Germany,Germany,Italy,Spain,Ecuador,Spain,Germany,Germany,Germany,China,Serbia,Greece,Romania,Sweden,Belgium,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Demonstrating innovative nature-based solutions in cities (H2020-SCC-NBS-2stage-2017, 2017)
Start date: 2018-06-01
End date: 2023-11-30
Duration (months): 66.0
Total project cost (EUR): 14864688.84
EU funding (EUR): 14214660.629999999
Participants: 37
Project status: SIGNED

Hamburg (DE), London (UK) and Milan (IT) have decided to create CLEVER Cities. Led by Hamburg, a well-balanced, competent partnership will position the EU as global leader in nature-based solution (NBS) innovation. CLEVER Cities applies a city centric approach, starting by key urban regeneration challenges and employing strong local partner clusters, to foster sustainable and socially inclusive urban regeneration locally, in Europe and globally. We will co-create, - implement, and -manage locally tailored NBS to deliver tangible social, environmental and economic improvements for urban regeneration. We are committed to make the interventions in front-runner cities (FR) cases for successful NBS and prepare robust replication roadmaps in fellow cities (FE), that also have NBS experience and expertise to offer. We will ensure long-term sustainability of actions in FR and FE by initiating urban innovation partnerships that will use SMART city principles to engage residents, establish new governance procedures, generate innovative financing and investment strategies. CLEVER Cities will employ partners’ large global networks to generate rapid and durable uptake of NBS by capacitating businesses and a CLEVER Solutions Basket with innovative technological, business, financing and governance solutions, in Europe and globally. The influential and committed FR will serve as role model for FE and global cities in East Asia and South America. All cities will actively engage in replication, thus, help to meet EU and UN sustainability goals and profile the EU as global leader in green innovation. CLEVER Cities materialises in strong local clusters around FR with partners, which can both support local co-creation as well as transversal activities with specific knowledge and expertise. This makes it a distinct, exciting project that will generate lasting results in cities and deliver a CLEVER Cities package with solutions, guidance and open-sourced data EU NBS reference framework.
Enhanced MUlti-Functional Membranes for Water Treatment and Desalination (Enhanced-MUMs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-25
End date: 2020-06-24
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Enhanced-MUMs targets the development of advanced multifunctional and low-cost polymeric membranes for water treatment and desalination. The main innovation resides in the combination of enhanced structural properties (high porosity and reinforcement) for improved desalination characteristics and light-induced antifouling and antimicrobial activity based on the loading of photosensitizers in the polymeric membrane. The economy of the approach is guaranteed by the polymeric material chosen for the realization of the membrane: PVC. The proposed breakthrough relies on the complementary expertise of the Experienced Researcher on polymer chemistry and nanofibers fabrication and of the supervisor’s group on polymeric materials characterization, photochemistry of organic materials and photosensitizers for photodynamic treatments. Enhanced-MUMs is a multidisciplinary project that aims at bringing high innovation in the forefront research area of water treatment and desalination. In the frame of the project the Experienced Researcher will widen her scientific skills and technological know-how with significant improvement for the development of her career.

Keywords: porous membrane,polymer,nanofiber,nanocomposite,photo active dye,water treatment,desalination
Prisons: the Rule of Law, Accountability and Rights (PRILA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Ireland
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2022-12-31
Duration (months): 81.0
Total project cost (EUR): 1428342.5
EU funding (EUR): 1428342.5
Participants: 1
Project status: SIGNED

PRILA will create the first account of how mechanisms for securing rights, ensuring accountability and achieving adherence to the rule of law are experienced in European prisons. Prisons are places where considerable power differentials exist, and are unique sites for the expression of the values which underpin public and prison law. Systems to ensure that prisoners are treated fairly and that rights are upheld are essential to ensure that imprisonment is conducted in ways that are just and promote good order. These are fundamental principles of the ‘European’ way in penal policy and penal law. Existing accounts of the deployment of penal power overlook key elements of how accountability, the rule of law, and rights are experienced. PRILA will document how prisoners, prison staff, staff of accountability bodies experience structures for ensuring decisions and actions taken in prison are fair, transparent, consistent, subject to appeal and review, and in compliance with principles of human rights. In doing so, PRILA will transform and extend accounts of legitimacy in prisons, judicial review of administrative action, the pains of imprisonment, and understandings of how penal power is experienced. Drawing on the disciplines of public and prison law, human rights, comparative law, and the sociology of punishment, the project will utilise legal, qualitative and quantitative research methods to create an account of how ‘accountability work’ is experienced. It will also examine how accountability structures are manifestations of penal ideologies or types of prison regimes. The project will advance current judicial and legal conceptions of accountability, the rule of law, and fairness, by reference to how these concepts are experienced in practice, and examine whether and how they are distinctively ‘European’. The project will thereby support the creation of better penal policies and practices aimed at the protection of the rule of law and rights in the prison context.

Keywords: imprisonment
Land Use and Climate Change Attribution for biodiversity impact assessments (LUCCA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2021-09-01
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Across the globe, species are shifting their distributions to track the warming temperatures, and habitat conversion is reducing species diversity. However, while both climate and land use change are recognized as top threats to biodiversity, studies on their synergistic effects are very rare. This is at least partly due to 1) a lack of consistent definitions and measures of land use change that can be directly related to biodiversity responses, and 2) difficulties in attributing change to either driver because of correlations, scale-dependencies, and interaction effects between the two. This project will develop a framework for separating the effects of land use and climate change on biodiversity using a range of methodologies such as meta-analysis, fieldwork, and modeling. The project will assess the land use definition and driver attribution challenges in the past literature, explore the potential of high-resolution remote sensing products and Google Street View to measure land use changes, and use unprecedented long-term monitoring citizen science programs to disentangle impacts of land use and climate change on bird populations as a case study. The Fellowship is a timely answer to recent calls to account for multiple environmental change drivers and improve our predictive ability of future biodiversity changes. The outputs will be of relevance for conservation management and policymaking in the EU and beyond. The host institute (CMEC) is at the forefront of macroecology and climate change research, and will give me access to worldwide experts in areas directly relevant to the project. The research and training opportunities offered by CMEC will broaden my field of study and strengthen my analytical and teaching skills – crucial for helping me establish an independent research career and become a leading figure within the field of integrative global change ecology in Europe.

Keywords: climate change,species distributions,land use change,environmental change attribution,range shifts
The Smartphone Payment Scheme for Europe (Bluecode)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria,Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 2743440.0
EU funding (EUR): 1920408.0
Participants: 2
Project status: CLOSED

Cash has been the most popular payment method for centuries, but it is quite cumbersome and expensive. Decades ago, the payment possibilities were broadened with cheques and debit/credit cards, and recently a new generation of alternatives brought by FinTech companies is disrupting the industry with eWallets, contactless payment, etc. However, most of these new payment tools inevitably involve resorting to USA-based card networks (Visa and MasterCard) and electronic payment tools (PayPal, Apple Pay, Google Wallet). This represents a dramatic situation for the European financial industry, threatened to lose the revenues generated by the transactions but also the ‘emotional’ link with customers and even the whole payment process (consumers migrating to USA banks). How can we help tackling this challenge? Blue Code is an innovative mobile payment solution that will avoid the need of resorting to USA players to conduct the non-cash payments in Europe. Through our 100% European payment scheme, the entire payment process is conducted with European entities, so all the revenues and customer interface remains internally. Besides, we assure ‘security by design’ through an innovative payment method based on barcodes (Tokens) that keeps all the process anonymous, so no sensitive data like name, address or bank account is managed, and thus there are no possibilities of hacking of misuse. In Europe, 130 billion non-cash transactions are performed each year and this number is growing 6.5% annually. The alternative payment methods like Blue Code are increasing its relevance and are estimated to process 20% of the total cashless transactions by 2020, taking one third of the total revenues generated, thus a total addressable market of €22 billion. Thanks to the technical advances and commercial milestones brought by this project, we estimate to generate €19.6 million cumulative profit by 2022 and 14 new job positions.

Keywords: digital payment,digital banking,fintech,non cahs payment,secure payment barcode payment
Topological Chemistry in Ternary Compunds (TOPCHEM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-16
End date: 2021-09-15
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

The discovery of topological insulators has ignited intensive research activity in condensed matter and materials science. However, the understanding of topological electronic structure from a chemical view is still deficient. This action proposes the investigation of novel ternary ABC topological insulators (A: alkali, alkaline earth, rare earth, Group 11, B: alkaline earth or Group 8-12, C: main group element) by focusing on three aspects: 1) growth of high-quality single crystals; 2) structural characterisation and relation between topological electronic structure and chemical concepts; 3) manipulation of electronic structure aiming at thermoelectric applications. First, high-quality ABC single crystals with selected composition will be grown by suitable methods. The Fermi level will be tuned by chemical doping or controlling the intrinsic defects to observe the topological physics. Subsequently, a detailed bulk and surface structural characterisation will be performed. The electronic structure of a material in the reciprocal space can be linked to chemical concepts in real space, such as chemical bonding, electronegativity differences, orbital overlap, etc. A systematic study of the crystalline bulk and surface structures will be performed by Synchrotron and low energy electron diffraction, and X-ray absorption near the edge, to find the relation between chemical concepts and the electronic structure of selected topological materials. Finally, based on the understanding of the relation between chemical concepts and electronic structure, the thermoelectric transport properties of these novel ABC topological insulators will be investigated and optimised for thermoelectric applications. The implementation of this project will deepen the understanding of topological chemistry and stimulate the technological application of topological materials. It will contribute to EU Horizon 2020 goals creating a single market for knowledge, research, and innovation.

Keywords: topological insulators,thermoelectricity,single crystals,solid state chemistry
Building up the Milky Way Halo in the era of multiple stellar populations (Global-assembly)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

In the Galactic halo the footprints of early hierarchical processes can be easily recognized, with some still observable events, such as the merging between the Sagittarius galaxy and the Milky Way. With the discovery of multiple stellar populations in globular clusters (GCs), we are entering a new era in the study of the halo. We now know that typical Milky Way GCs host different stellar populations, with some of them resembling the Sagittarius nuclear GC M54, and Omega Centauri, proposed to be the survived nucleus of a dwarf galaxy. Recent photometric effort has revealed that the "populations pattern" in GCs is even more complex than previously believed, with the observation of minor populations for which we still do not have information of their nature, i.e. of their chemical composition. Many aspects about the nature of GCs are matter of a lively debate: Which is the origin of GCs? Could have some of them been former nuclei of dwarf galaxies? Which is their contribution to the halo? To answer these questions we lack a systematic and comprehensive analysis of the nature of “all” the stellar populations observed in GCs. Recently we have photometrically detected multiple stellar populations in the young GCs of the Magellanic Clouds (age of few hundreds Myrs). Are these the young counterpart of the old Milky Way GCs (10<age<13 Gyrs)? If yes, we have the unique opportunity to analyse, in the local Universe, an obscure phenomenon occurred at high redshift. To address this issue a chemical characterisation of the stellar populations observed in these young GCs is needed. Thus, the new revolutionary photometric discoveries impose a major effort in the chemical/kinematical analysis of this phenomenon. With this project, I propose to exploit my expertise in spectroscopy in close synergy with photometric techniques to provide for the first time a full characterisation of all the observed stellar populations in GCs to reconstruct the phases of their formation and evolution.

Keywords: star clusters,population 2,spectroscopy,chemical abundances,milky way halo
Promitil® - a new ‘smart’ nanomedicine for cancer chemo-radiotherapy. (Promitil)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-07-01
End date: 2019-11-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

There were over 18M new cases of cancer worldwide in 2018, out of which about 3.7M were in Europe. To treat cancer, radiotherapy is increasingly used in combination with chemotherapy. Chemo-radiotherapy is a non-invasive approach for cancer local control, given within a reduced period time and with potential for complete cure of cancer. The key to enabling the full potential of chemo-radiotherapy depends on radio-sensitization, which means the degree of effectiveness of the anti-cancer agents used for chemotherapy that make tumour cell more sensitive to radiation therapy. However, radio-sensitizers, like Mitomycin-C (MMC), still need to be significantly improved to achieve a more effective and safe treatment of patients. LipoMedix has developed a novel nanomedicine (Promitil® ) for chemo-radiotherapy. It is a liposome formulation of a Mitomycin-C Lipid-based (MLP) prodrug of the anticancer agent MMC. Promitil® enables efficient delivery of MLP with rapid activation in tumour tissue, yet with improved safety profile because it becomes active only upon radiation. This results in a higher and safer radio-sensitization effect. LipoMedix is an Israeli pharma SME founded in 2011. Its team has been involved for more than 20 years in cancer drugs and therapies, and now its mission is deliver to a novel, efficient, and side-effect free liposome prodrug to improve patients’ quality of life, healthcare outcomes and reduce the economic healthcare stress of chemo-radiotherapy. The SME-I Phase 1 project perfectly suits the innovation’s current stage of development and overall business strategy allowing LipoMedix to check final specifications of Promitil®, establish sound business development and gain partners necessary for the Phase II study.

Keywords: chemo radiotherapy,mitomycin c,liposomes,radiosensitizer,clinical trial