Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Graphene Nano-Photonics (GRANOP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-08-01
End date: 2015-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Graphene, a single-atom layer of carbon, has attracted enormous attention in diverse areas of applied and fundamental physics. Due to its unique crystal structure, the charge carriers have zero effective mass and can therefore travel for micrometers without scattering, even at room temperature. While graphene-based devices have an enormous potential for high-speed electronic devices, it has recently also been recognized as a photonic material for novel optoelectronic applications. Surprisingly, little attention has been devoted to graphene-based nanophotonic applications where optical fields are confined far below the diffraction limit. Due to its ultrasmall thickness and extremely high purity, it supports extremely strong wave localization at the nanoscale (also identified as surface plasmons) with relatively low losses. Moreover, graphene can be tuned from a semiconductor to a metal simply by applying a gate voltage, holding promise for in-situ tuneability of strong light-matter interactions at a length scale far below the wavelength. This makes graphene the ideal material to synergize nano-optics and electronics at the nanoscale. This research will demonstrate the application of graphene as a novel nano-photonic material that outperforms greatly existing photonic materials (cavities and metals). We will engineer ultra-strong and coherent light-matter interactions between single emitters and graphene, and implement several quantum electrodynamics (QED) applications. This research will address fundamentally new phenomena associated to the peculiar properties of graphene, while the development of this novel type of integrated nano-optoelectronic device will enable potential applications ranging from nanoscale (quantum) optical switches and quantum information processing, to super-efficient light collection, and ultra-fast and sensitive sensing of single (bio) molecules.

Keywords: optical and dielectric properties,solid state physics,nanodevices,quantum technology,optoelectronics,nanoelectronics
Novel Strategies for Microsphere-Mediated Cellular Control - A Technology to generate induced pluripotent stem cells for Regenerative Medicine (RSM-MICROSPHERE-IPSC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-09-01
End date: 2015-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

A crucial goal of regenerative medicine is to generate desired cells, to build a specific tissue, from pluripotent stem cells directly derived from a patient's cells. These cells are known as induced pluripotent stem (iPS) cells and they have a potential therapeutic use as they offer an alternative to the controversial use of embryonic stem cells and, additionally, they avoid the issue of immune rejection. Nowadays the finding of an efficient and safe transfection method to introduce the appropriate genes (Oct3/4, Sox2, c-Myc and Klf4) into adult cells to obtain pluripotent stem cells is a bottleneck that could limit the use of iPS cells in humans. There is a need for a safe method for the production of pluripotent cells from adult human cells. Herein the development of a non-viral method for generating iPS cells is proposed. The broad aims of this research project are the design of novel strategies (based on solid phase chemistry) for the application, exploitation and development of a generic microsphere cellular delivery system for the release of a desired therapeutic cargo (such as DNA and protein) into adult human cells to induce the formation of iPS cells. This aims will be carried on by applying the skills in cellular delivery systems that the applicant acquired during her stay at the University of Edinburgh (UK) as a Research Fellow for the last five years. The project is a multidisciplinary approach with a synthetic chemical part to be developed at the University of Granada, where the applicant has recently been incorporated as Lecturer in Medicinal and Organic Chemistry, and a biological part to be developed at the Andalusian Bank of Stem Cells in collaboration with Dr. Garcia Perez, an specialist in the area of reprogrammation. The project deals with a topic of interest in European Research as it faces the treatment of many diseases by applying regenerative medicine based in the formation of iPS cells.

Keywords: health sciences-cellular delivery-carryer system-transfection method-microsphere-solid phase chemistry-conjugation strategies-protein delivery-induced pluripotent stem(ips) cells-regenerative medicine
Cancer-Associated Bone Disease; Role of Obesity and Adipokines (CABROA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-12-01
End date: 2015-11-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Cancer-associated bone disease is a major cause of morbidity and mortality for patients with the haematological malignancy multiple myeloma, or with skeletal metastases from primary tumours such as prostate cancer. In order to identify new therapeutic targets, it is necessary to elucidate the complex mechanisms within the bone marrow that promote both tumour growth and the associated bone disease. There is increasing evidence to suggest that obesity and adipokines are associated with malignancy, however their role in bone metastases is unknown. Our studies have identified a key role for host-derived adiponectin in the pathogenesis of myeloma bone disease, and preliminary studies suggest that decreasing adiposity can reduce tumour burden. Our overall hypothesis is that obesity and the dysregulation of adipokines, including decreased adiponectin, promote tumour growth within the bone marrow and the development of cancer-associated bone disease. In our investigation of this hypothesis we propose to focus upon multiple myeloma and prostate cancer bone metastases. We will use a powerful combination of in vivo models of cancer-associated bone disease, clinical samples from patients with skeletal metastases, and detailed cellular and molecular studies. The effect of obesity will be investigated using murine models of diet-induced obesity. The specific effects of bone marrow adiposity will be determined using pharmacologic approaches to specifically inhibit bone marrow adipocytes. In addition, we will determine the function of select adipokines in the tumour-bone marrow microenvironment in vitro and in vivo. Taken together, these studies will identify the role of adiposity and adipokines in the pathogenesis of the skeletal metastases associated with prostate cancer or multiple myeloma, and will reveal new therapeutic approaches for the treatment of these devastating malignancies.

Keywords: myeloma,prostate cancer,bone,obesity,adiponectin,adipokine
NUCLEOLAR-DEPENDENT SECRETION OF MICRORNA IN A MODEL OF DOXORUBICIN AND TRASTUZUMAB CARDIOMYOPATHY. (NUMIRDT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-09-01
End date: 2015-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Combination of Doxorubicin (Dox) and the monoclonal antibody trastuzumab (Trz) is being effectively used against breast cancer, but associated with high incidence of cardiotoxicity. The mechanisms of Dox+Trz induced synergic cardiotoxicity are still unclear. Recently the activation of the microRNA 146a has been shown to have a role in the synergistic effect of Dox and Trz cardiotoxicity. MicroRNAs (miRNA) are ~22 nucleotides long non-coding RNAs regulating complex cellular processes. MiRNAs can be detected in the systemic circulation and their levels increase under various stress conditions. Growing body of evidence suggests that circulating miRNAs are actively released and may act as signaling molecules on close or even distant target cells. Mechanism of miRNA secretion is not completely characterized Recent literature suggests a intriguing idea that the nucleolus may play a critical role during miRNA release and reuptake . The short term goal of this proposal is to identify a diagnostic signature of circulating miRNA in response to Dox+Trz treatment. The long term goal is to study the mechanisms of release and reuptake of miRNAs and demonstrate the role of the nucleolus in these processes. Specific tasks will focus on: 1) Analysis of circulating miRNAs from plasma of mice treated with Saline, Dox or Dox+Trz. 2) Identification of secreted miRNAs in response to Dox, Trz , and Dox+Trz in adult human cardiac stromal cells (hCStCs) and cardiac progenitor cells (hCPCs). 3) Study the mechanism/s of release and uptake of miRNAs upon stress. 4) Role of the nucleolar protein nucleophosmin (NPM) on miRNAs export and uptake upon stress. Significance is the delineation of new mechanisms controlling myocardial stress response and identification of molecular interventional targets that mitigate drug-mediated cardiotoxicity and improve myocardial survival.

Keywords: health sciences,doxorubicin,trastuzumab,mirna,exosomes,nucleolus,nucleophosmin
Investigation of LTE-Advanced for Network Behaviour, Energy and Intelligent Transportation Systems (LTE BE-IT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2011-10-01
End date: 2014-09-30
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

The usage of new internet-based services with the wireless mobile devices has an unlimited potential as we have just witnessed in the Egyptian revolution and disaster relief in Haiti. However, currently available wireless cellular technology 3G has been unsuccessful in delivering multimedia with acceptable level of quality due to the low transmission rate and high service costs. Thus, a 4G standard LTE-Advanced has been developed intended for larger capacity and higher speed of mobile networks. However, despite its promising potential, LTE-Advanced-based technology is still at infant stages and there is much work need to be done for wider commercial operation. The objective of this application is to advance 4G-based wireless mobile network utilizing multidisciplinary research approach. It is a step toward attainment of my long-term career goal, which is to further develop my expertise in wireless network communications while advancing academic career. The motivation of the project is that evaluating LTE-Advanced-based protocols and applying the technology for practical applications will improve our mobile communication. The rationale for the proposed research is that once effective LTE-Advanced-based technologies are established, it enables a wide range of commercial operation throughout the world thereby stimulating economy in EU countries where major mobile communication industries are concentrated. Furthermore, the general population will be benefited from 4G-based mobile communication services, which are currently not available e.g. Intelligent Transportation Systems. I plan to accomplish my objective by pursuing the following Workpackages (WP): Specific WP1) Evaluate LTE advanced protocols to identify potential bottleneck of LTE network, Specific WP2) Develop an energy-efficient wireless network solution, Green Network, for LTE/LTE-Advanced, Specific WP3) Apply LTE/LTE-Advanced communication technology to Intelligent Transportation Systems (ITS).

Keywords: lte-advanced,performance,network behaviour,energy,intelligent transportation systems,its
Integrated SAfety Benefit Estimation tooL for 2-wheeLErs (ISABELLE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Greece
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-06-01
End date: 2017-11-11
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The traffic accidents, with 2wheelers like bicycles, motorcycles and mopeds, represent 23% of total road fatalities in EU. Even though until now there is no clear understanding of the mechanisms of injury of such vehicles. The lack of knowledge and uncertainties of the complex dynamics of 2wheelers accidents is limiting the advancement of protective equipment for them. This is a reason that most of the efforts for development of protective equipment were focused only on helmets and protective clothing and not on devices that would prevent the riders’ impacts with other vehicles or the environment i.e. for the development of motorcycle airbags rather contradictory results came out for their safety benefit attributed from the authors to the overestimation of neck-injuries from the dummy used in the crash-tests. Further electric 2wheelers and new types of innovative ultra-light electric vehicles that offer sustainable urban mobility are developed or already introduced in the market with similar concerns for their safety as the traditional 2wheelers. These types of vehicles are expected to increase their fleet due to their advantages in urban mobility, increasing also their proportion in traffic injuries if their safety concerns are not addressed.The goal of this project is to develop deeper understanding of the injury mechanisms of motorcycle accidents and a new framework for the assessment of safety of all 2wheelers. This project will be realized with focus on motorcycles but the developed methodology, and tools will be applicable to all other 2wheelers.The major expected results of this project are: (a) an ambulatory motion capture system, (b) new knowledge on motorcyclist’s kinematics, (b) development of a biofidelic numerical active human model, (c) better understanding of the motorcycle accident’s injury, (d) the creation of a database of simulations. The simulation database will be developed for motorcycles but it will be applicable to all other 2wheelers.

Keywords: motorcycle,traffic safety,mechanical engineering,biomechanics,accident reconstruction,mechanisms of injury,accident database,motion capture,human model,multi body,simulation,bicycle,crash
High-resolution dating of sedimentary archives (HIRESDAT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2011-CIG, 2011)
Start date: 2012-01-01
End date: 2015-12-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Following my success getting a first class CNRS research assistant position, I just arrived at the laboratory of Géosciences Rennes (UMR - CNRS 6118) of the Université Rennes 1 in October 2010. As a specialist in dating rocks by magnetic methods (paleomagnetism), I was attracted by the willingness of Geosciences Rennes laboratory to develop the most complete range of possible methods for the dating of rocks in order to understand the evolution of climate, environment and reliefs. Within this project, I bring methods making the link between geology and climatology. Specifically, it consists in dating, with the best accuracy possible today, sedimentary archives that have recorded past climate variations. The problems addressed are very diverse and include the formation of landforms, dating the evolution of hominids or studying regional or global climate changes (warming, monsoons, ...) and their environmental implications (desertification, sea level change, species extinction, ...). This emerging method for dating sediments is an essential component to complete the rock dating platform that is currently being built in Geosciences Rennes. The budget allocation requested is to be used to finance the implementation of these methods by building an automated system for measuring the magnetization of rocks and a magnetically shielded room to host the automated system. These devices are essential for the intended high-resolution study of continuous sediment record. It can be installed at a lower cost due to my extended past experience in foreign laboratories. This simple but crucial laboratory facility upgrade will expand dramatically the scope of the laboratory. This is essential to remain competitive internationally in a sustainable way, not only in dating rocks but also for direct applications to climatology and environmental sciences.

Keywords: earth science,environmental science,stratigraphy,climate change,tectonics,geophysics
Modulation of cortical activity by median raphe neuronal assemblies with identified behavioural effects (SERRACO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: Hungary
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-03-01
End date: 2017-02-28
Duration (months): 60.0
Total project cost (EUR): 2700000.0
EU funding (EUR): 2700000.0
Participants: 1
Project status: CLOSED

Cortical operations are built up from states associated with distinct behaviour-dependent network activity patterns that subserve information aquisition, encoding, memory consolidation and retrieval. Thus, they can be considered as manifestations of different processing modes. Groups of modulatory, largely monoaminergic neurons located in subcortical nuclei innervating all forebrain areas are indispensable for the generation, stabilization and termination of cortical activity states. In recent years the concept of subcortical modulation has been expanded by the discovery of a fast type of modulatory action driving the rapid readjustment of cortical activity and associated behaviours. Thus, cortical networks are under the influence of a tonic, slow, as well as a phasic, rapid component of subcortical modulation that are acting in parallel. Results from our laboratory revealed that the median raphe (MR) nucleus, one of the main sources of serotonergic innervation of the limbic system , besides the non-synaptic diffuse action, also exerts a fast type of modulation via the selective innervation of cortical GABAergic interneurons. This selective effect on local inhibition may be ideal for the synchronous resetting of the target principal cell circuits, or for the continuous tuning of their activity. These discoveries, together with the methodological advances of recent years, enable us to map the neuronal network mechanisms behind transitions of brain states, as well as associated behaviours, induced by subcortical inputs. We will focus on the MR – limbic connection with the aim to unravel the physiological, pharmacological and anatomical features of MR neuronal assemblies, both the slow- and fast-acting, as well as the serotonergic and glutamatergic components (together with their cortical target circuits) that will have been shown - using optic stimulation of ChR2/eGFP virus-infected MR neurons - to evoke characteristic behaviours, such as anxiety and conditioned fear.

Keywords: gaba,inhibition,interneurons,hippocampus,cortex,amygdala,serotonin
Evolution of evolvable systems (EVOEVO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: ERC Advanced Grant Interdisciplinary Panel
Countries involved: Germany,France
Call:  (ERC-2011-ADG_20110310, 2011)
Start date: 2012-07-01
End date: 2017-06-30
Duration (months): 60.0
Total project cost (EUR): 2616700.0
EU funding (EUR): 2616700.0
Participants: 2
Project status: CLOSED

This proposal investigates the origin of three evolvable systems in biological evolution. The first pillar deals with early evolution/origin of life. It is the heaviest part of the proposal, with a strong experimental participation of a co-PI. We shall invetiage how genes, metabolism and membranes could have evolved to yield the first living cells. Intermediate stages will be proposed, modelled and when possible experimentally tested by a combination of molecular biology, in vitro compartmentation and microfluidics. The second pillar theoretically investigates the origin of the adaptive immune system as a within-organism evolvable system. The third pillar investigates how informational replication and natural selection could be rendered within evolved brains, in order to better understand how reinforcement learning, insight and language emergence work durig individual development.

Keywords: major transitions in evolution,rna world,evolvability,complex thinking,language,replicator dynamics,evolution in neuronal networks