Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Quantum boundary conditions for infinite-dimensional control (QuBICo)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: TERMINATED

Taking advantage of the underlying quantum features of the natural world to design new technologies is the principle at the root of the Second Quantum Revolution. Quantum control theory provides the mathematical substrate to this principle by establishing precise conditions under which a system can be manipulated to reach any desired state in a finite time, and developing systematic methods for accomplishing this goal in an optimal way. This is a formidable task especially for systems with infinitely many degrees of freedom, for which advanced mathematical techniques are needed. The standard approach to quantum control relies on the use of external fields. A significant byproduct of such schemes is the possible loss of quantum correlations between the components of the system resulting from this interaction. An alternative route is achieving control by exploiting boundary effects, that is, manipulating the boundary conditions of the system. This is the idea at the core of Quantum Control at the Boundary (QCB), a promising yet underdeveloped paradigm. The aim of the project is to investigate the feasibility and shortcomings of QCB, laying the foundations to a systematic theory of boundary control schemes. By adopting and improving known results from infinite-dimensional control theory, the project will elucidate the conditions under which specific QCB schemes, including thick quantum graphs and cavities with moving boundaries, are controllable. The problem of optimal control and the practical implementation of such schemes will also be studied. The project draws ideas and techniques from different areas of mathematics and physics, by also requiring familiarity with the laws of Quantum Mechanics. This reflects the scientific background of the applicant. It will involve a significant transfer of knowledge to the host institution, and the training of the researcher from a scientific and a managerial point of view.

Keywords: quantum control,quantum boundary conditions,quantum graphs,approximate controllability,optimal control
Enabling DURAble, sustainable and resilient conCRETE infrastructure via vascular self-healing solution (DUROCRETE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: United Kingdom
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Concrete is the most used material in the world but it comes with two big challenges (1) Concrete production is very pollutant and (2) Concrete cracks, allowing moisture and chemical ingress which in turn leads to corrosion of reinforcing bars (rebars). Damage requires rapid repair/replacement of pieces or the structural integrity of the build is compromised and can result in structural collapse (e.g. Ponte MoraNdi, 2018; Champlain Towers, 2021). MIMICRETE aims at revolutionising the construction industry by reducing the environmental impact and maintenance costs of infrastructure through our cutting-edge self-healing concrete technology. Our goal is to promote long lasting construction and infrastructure with a new type of self-healing concrete in which healing agents are delivered directly to the site of concrete damage through an embedded 3D vascular network, restoring the material properties of the concrete rapidly and without the need for external application of repair materials. In contrast to state-of-the-art solutions, our technology requires no manual intervention post-installation. It increases the strength of the concrete on day one and more than doubles its lifespan, leading to lower maintenance cost of at least 42%. The extension in lifespan reduces the volume of concrete utilised in the overall built environment, and it can in turn reduce the negative environmental impact of construction itself up to 50%. No other repair system can repair damaged concrete multiple times, nor can it repair large and small cracks effectively, nor has the flexibility of the healing material that can be used. With DUROCRETE project we aim to take our technology to TRL 9 to reduce the need for more expensive repair or rebuild of concrete structures. For this purpose we will be working with key partners including Holcim, Ferrovial or the The Henry Royce Institute and manufacturing partners such as ABM or Xometry to improve and demonstrate our technology.

Keywords: self healing concrete,precast concrete repair,materials engineering,microsystems engineering,smart concrete,healing agent,biomimetic structures
Next Generation Vaccine Platform Leveraging Skin Immunity to Provide Disease-Modifying Treatment of Parkinson’s Disease (NEXGEN-PD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Austria,Hungary,France,Germany,United Kingdom,Netherlands
Call: Pre-clinical development of the next generation of immunotherapies for diseases or disorders with unmet medical needs (HORIZON-HLTH-2022-DISEASE-06-two-stage, 2022)
Start date: 2023-04-01
End date: 2027-03-31
Duration (months): 48.0
Total project cost (EUR): 6071762.5
EU funding (EUR): 6071762.5
Participants: 13
Project status: SIGNED

Parkinson’s Disease (PD) is a major neurodegenerative disorder with no established treatment modalities capable of modifying disease pathology, and no means of early diagnosis. Vaccines targeting aSyn aggregates are a promising route to disease-modifying therapy for PD, but the current generation of PD vaccines utilise conventional formulations, which are limited in their immunogenicity and require substantial quantities of adjuvant to achieve efficacy. NEXGEN’s proprietary WISIT vaccine platform is the first of the novel class of gluconeoconjugate vaccines (GNCVs), which are administered intradermally and specifically formulated to leverage skin dendritic cells (DCs) to generate substantially stronger and more specific immune responses than conventional vaccines. These stronger immune responses allow substantial reduction in adjuvants, while simultaneously increasing therapy efficacy. NEXGEN will identify and characterise candidate WISIT constructs targeting aSyn (PD-WISITs) and develop a novel extracellular vesicle (EV)-based biomarker assay that enables early diagnosis of PD using liquid biopsies, suitable for point of care use. Safety and efficacy of PD-WISITs will be demonstrated preclinically, before being translated to first-in-human Phase I/Ib clinical trials, along with the novel EV-based biomarker assay. The results of NEXGEN will be the extraordinary accomplishments of cheap and effective disease-modifying treatment of early PD and a novel biomarker assay to diagnose and guide prodromal/early PD treatment. Further still, GNCV technology will be clinically demonstrated, which has the potential to be transformative to the treatment of a wide range of additional diseases, resulting in far-reaching impacts to the health of millions.

Keywords: therapeutic vaccine,parkinson s disease,disease modifying,alpha synuclein,biomarkers,extracellular vesicles,clinical trial,antibodies,synucleinopathies
Governing, Optimising and Leveraging Innovations proActively for shaping future proof holistic mobility system through data-driven and social optimum-led model (GOLIA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Netherlands,Greece,Belgium,France,Norway,Czechia,Switzerland,Germany
Call: Policies and governance shaping the future transport and mobility systems (HORIZON-CL5-2024-D6-01, 2024)
Start date: 2025-06-01
End date: 2028-05-31
Duration (months): 36.0
Total project cost (EUR): 3227811.02
EU funding (EUR): 2977814.6
Participants: 22
Project status: SIGNED

GOLIA will work on an integrated, interdisciplinary and Adaptive Mobility Smart Governance Model, relying on data-based, social optimum-driven approach and inclusive policy making processes to ensure an adaptive, accessible and just mobility system. By relying on the integration of STEM and SSH expertise and approaches, GOLIA will revolutionize spatial and mobility planning by co-developing and testing (with three European communities) the vision-led Social Optimum Mobility Index, based not only on economic variables but also on indicators such as social support, healthy life quality, freedom to make life choices. The index will be location and time-dependent to enable dynamic management of transport offer and spaces. GOLIA also aims at understanding: - to which extent and under which conditions, data generated by Smart Cities supported by AI-based tools and - novel communication and consultation channels and methodologies to engage citizens and stakeholders beyond mobility practitioners might foster the establishment of a new inclusive and adaptive mobility governance, able to deliver policies resilient to political instability, pandemics or any other more or less disruptive event, as they are co-developed, co-designed, and co-monitored by and for citizens and firms. Finally, GOLIA will support European mobility communities in ensuring a Sustainable digital and green transition, by providing policy makers with tools, methodologies and evidence-based recommendations to align local, regional and national transport and mobility plans to the European Green Deal and Sustainable Development Goals, enabling the gradual phase-out from car-dependency.

Keywords: governance,policy making,maar,social optimum
Inhibition of the potassium channel TREK1 by mTOR: a mechanism for aberrant neuronal excitability in mTORopathies (TOR-TREKking)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-02
End date: 2027-05-01
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

Neurological disorders, such as epilepsy and autism, affect millions of people worldwide with the underlying causes ranging from genetic mutations to developmental issues. Treatment options vary widely from anti-epileptic drugs to more severe approaches such as surgical interventions, underscoring the need to understand the underlying causes for developing effective treatment strategies. Among these neurological disorders are mTORopathies, a group of genetic diseases characterized by the dysregulation of the mechanistic Target Of Rapamycin (mTOR) signaling pathway. The most common mTORopathy, Tuberous Sclerosis Complex (TSC), leads to significant health challenges resulting in a reduced life expectancy of 10-20 years for affected newborns. Despite crucial progress in understanding mTOR dysregulation, the precise mechanisms by which it causes neurological hyperexcitability remain unclear, and current treatments present important limitations. This project aims to unravel the molecular mechanisms driving mTORopathies and to develop targeted therapeutic interventions. The first comprehensive study of phosphorylation landscape in TSC brain in the host laboratory has identified TREK1 potassium channel as a novel target, potentially playing a critical role in the development of epileptic seizures. Using a range of multidisciplinary approaches, from molecular and cell biology techniques to neurological analyses, I aim to gain invaluable insights into the molecular mechanisms underlying mTORopathies. Furthermore, by generating mouse models with modulated TREK1 activity, I aim to identify novel therapeutic strategies to counteract TSC. Understanding the molecular program underlying these diseases is essential to develop targeted therapies that improve patient outcomes. This research can significantly enhance our understanding of neurological disorders and contribute to more effective treatments, ultimately leading to improved outcomes and better quality of life for patients.

Keywords: mtor,growth,seizures,trek1,neuronal excitability
Accelerating biofilm Matrix dispersion with Deep Eutectic Solvents (AMADEUS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Ireland
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2024-10-01
End date: 2026-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

A growing demand for clean water is driving the increased adoption of water-recycling and water-desalination, particularly in water-stressed regions. These processes are highly dependent on the use of membrane filtration technology. Efficient operation of these membranes is hampered by biofouling which is typically managed by chemical treatment. Amongst end-users in the water treatment sector, there is a market-pull towards more green/sustainable chemicals and this, combined with the limited effectiveness of existing biofouling control products, has created the substantial commercial opportunity described in this proposal. The unique idea in this Proof of Concept is to use natural deep eutectic solvents (NADES) as a non-toxic and tuneable solution for biofouling mitigation. Preliminary data from the PI’s ERC grant, ABSOLUTE, has demonstrated that novel NADES formulations an effective, safe, scalable and economically viable solution for biofouling mitigation. The project deliverables include: (i) A composition for a NADES-based biofouling control product that exceeds the performance of the closest competing product and is superior in terms of reduced toxicity and higher biodegradability. (ii) A patent filing and a scalable commercialisation strategy. (iii) Data that confirms the cost benefits of the NADES composition in key industrial sectors. (iv) Demonstration data in to obtain feedback from end-users, partners and potential investors. These deliverables will advance the technology towards rapid commercialisation via a university spin-out company.
PLant AdaptioN to Elevated Temperatures: mitigating crop losses caused by climate change (PLANeT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2023-11-01
End date: 2025-04-30
Duration (months): 18.0
Total project cost (EUR): 201428.57
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

Agricultural ecosystems are severely pressed by global warming. Elevated temperature consequence of climate change is causing dramatic crop and economic losses while threaten the healthy and sustainable living standards of most European citizens. Predictions on increased ambient temperatures between 1.5-4ºC pose on danger food security globally for the coming years. In the context of European Research Council (ERC) Consolidator Grant (IDRICA-683163), our lab found that vascular Brassinosteroid receptors can confer resistance to several abiotic stresses without penalizing plant growth, disclosing a yet unexplored innovation potential (EU patent application P6100130EP; 2021). These findings were initially obtained in the model Arabidopsis and the emerging hypothesis has been now tested in Brassinosteroid mutants of cereal Sorghum. We found that hypocotyl and mesocotyl growth on selected mutants is compromised upon elevated temperatures in both Arabidopsis and Sorghum respectively, supporting conserved mechanisms across species. These findings enable a novel HighThroughPut (HTP) screening capacity for compounds/biologicals to overcome the most damaging impacts of warming in crops. Upon initial HTP screening, this proposal aims to enter into a valorization path towards lead generation through a computationally-assisted screening cascade to identify cost-effective Lead compounds that can improve crop yield at elevated temperatures. Overall, PLANeT takes the opportunity for transferring proprietary knowhow into value to market-creating innovation in the Agricultural industry.
High-throughput production of anisotropic 3D human tissue models (AnisoPlate)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-09-01
End date: 2026-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The limitations of current in vitro tissue models pose a significant challenge in drug discovery and personalized medicine, leading to inefficiencies and unreliability in preclinical testing. These shortcomings result in high costs and prolonged timelines for drug development, straining resources and delaying patient access to innovative treatments. This is mainly due to the currently available cell and tissue models based on flat petri dishes and isotropic hydrogels, which fail to accurately represent the anisotropic structures found in native tissues leading to unreliable preclinical results. Animal models, although considered the gold standard, raises ethical concerns and introduces significant differences compared to human tissues. To address these shortcomings, we have developed a hydrogel system that can be used to fabricate 3D culture models with oriented structures using AnisoPlate. The AnisoPlate is a handheld magnetic device for providing the required external magnetic field in culture plates for the orientation of the rods. The hydrogel system consists of rod-shape elements that are made magneto-responsive by encapsulating superparamagnetic iron oxide nanoparticles (SPIONs). When exposed to low external magnetic fields (in the millitesla range) provided by the AnisoPlate, these rods align in the direction of the field and can be assembled into 3D macroporous oriented constructs mimicking the anisotropic architecture of human tissues. Our solution holds promise not only for researchers in drug discovery, tissue engineering, and regenerative medicine but also for pharmaceutical industries seeking physiologically relevant in vitro models for more accurate preclinical studies, contract research organizations (CROs) aiming to enhance their efficacy in high-throughput screening, and ultimately patients who stand to benefit from accelerated and improved drug development processes leading to innovative treatments.

Keywords: anisogel,anisoplate,magneto responsive,anisotropic,3d hydrogel,tissue model,disease model,3d structure,drug discovery,drug development,preclinical,personalised medicine,animal model,3d macroporous,in vitro
The Unveiling of Fernando Pessoa’s Literary Legacy: The Duke of Parma (THEDUKE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 1
Project status: SIGNED

This proposal aims to study the genesis of the unpublished drama The Duke of Parma, a Shakespearean-inspired five-act play written in 16th-century English by one of the most renowned authors of the XX century: Fernando Pessoa (1888-1935). By interpreting the creative process behind the composition of the drama, THEDUKE will challenge the established idea of a literary text as a static product and will bring to the public’s attention the last hidden gem in Fernando Pessoa’s archive. Using palaeographic techniques, together with the help of an AI-powered tool for Handwritten Text Recognition (HTR), a material analysis of the manuscripts will be performed to determine their textual context and identify the textual variants. A further investigation of the author's archive and private library will be conducted to analyze the influences of external literary sources on the drama's genesis. To reach its objectives, THEDUKE requires an interdisciplinary approach and draws on the collective knowledge of Portuguese Literature, English Literature, History of Theatre, and Textual Criticism. The results of THEDUKE will be hosted on an open digital database, which will display images of the manuscripts, provide transcriptions, and offer insight into the compositional process. This project will hold substantial implications for Lusophone Literature, Modernist Literature, and the History of Theatre since it will shed light on a fundamental piece of Pessoa’s dramatic piece, and it will generate new critical perspectives in the realm of European literature. At UNIPR, I will collaborate with experts in Renaissance English Literature and Digital Humanities to combine my specialized knowledge of the genesis of Pessoa's work with theirs to ensure the project's success. My prior research experience, along with the new competencies I will acquire will allow me to become a recognized specialist in Pessoa's work and bolster my position as an expert researcher in Portuguese Literature and Text

Keywords: fernando pessoa duke of parma textual criticism genetic criticism dramatic literature comparative literature modernism textual variants digital archive shakespearean vogue