Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Regulation of cell division by alternative splicing (SPLICING IN MITOSIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 271868.4
EU funding (EUR): 271868.4
Participants: 1
Project status: CLOSED

The complexity of the mammalian proteome is far more extensive than can be explained by a simple one gene: one protein paradigm. The use of alternative splicing (AS) is emerging as a core regulatory mechanism, in a similar way to whether a specific gene is transcribed or repressed, or a protein is degraded or stabilised. Also like both transcriptional and post-translational control, it seems that almost every gene in the human genome undergoes AS. Despite this, the role of AS in a fundamental cellular process, such as cell division is still poorly understood. This proposal aims to tackle this problem by assessing the role of AS in cell division. The recent identification that the machinery involved in splicing, the spliceosome, is regulated by post-translational modifications (PTMs) during cell division strongly suggests AS, alongside PTMs, may have a core regulatory role in mitosis. This project proposal is therefore timely and will gain insights into this universal cellular process. I will use a multidisciplinary approach of combining next-generation mRNA sequencing in human cells to take snapshots of multiple stages of cell division with validation using proteomic datasets. Further validation of individual candidates will be done by high-throughput fluorescence microscopy to discover potential novel regulators of cell division. Furthermore, I will assess the segments removed by AS for functional modules known to modulate protein abundance and stability. A web-based relational database will be developed to disseminate our findings to the scientific community This proposal will assess the occurrence of splice variants during mitosis and aims to discover new regulators of cell division. The interdisciplinary approach and the data produced in this proposal will be highly beneficial for future research. More importantly, the research results will further our understanding a number of major diseases, such as cancer, which are a major socioeconomic concern in Europe.

Keywords: alternative splicing,cell division,mitosis,protein stability,mrna-sequencing,protein regulation
Demography, Ecology, Evolution and Management in the Deep (DEEMDEEP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-03-23
End date: 2017-07-03
Duration (months): 24.0
Total project cost (EUR): 169800.0
EU funding (EUR): 169800.0
Participants: 1
Project status: CLOSED

The oceans, upon which humanity relies for its survival, it is largely unexplored. Recent estimates establish that only 5% of the bottom of the sea has been explored. Of this small area, only one millionth is constituted by deep sea floor. Despite being largely unknown, the deep sea is becoming exceedingly exploited, especially by fisheries searching for new stocks. For all these reasons, understanding the functioning of the deep-sea environment is deemed crucial. This habitat has a pivotal role in the global conveyer belt, through regeneration of nutrients. This proposal (DEEMdeep) aims at expanding our understanding of the deep sea ecological and population dynamics through a strong multidisciplinary approach. The chosen taxon is the genus Molva, represented in the North Atlantic by two species, the common ling M. molva and the blue ling M. dypterygia. The novelty of this project is represented by its holistic multidisciplinary approach. State-of-the-art next-generation sequencing techniques will be simultaneously used with life-history traits, otolith microchemistry and stable isotopes analyses, parasitology and analysis of the fish gut microbiome in order to establish patterns of population connectivity and habitat interactions at the ecological level. Samples of common and blue ling will be collected throughout the North Atlantic in five sites (Norway, Iceland, Scotland, Greenland and Quebec) through scientific surveys. Basic traits will be recorded (length, weight and maturity), otoliths stored for microchemistry and stable isotopes analyses, gills removed for subsequent identification of the parasites and gut content sampled. Through enhancing our knowledge of the deep sea, this project will pave the way towards sound conservation (and management) of this resource.

Keywords: deep-sea,molva,atlantic,genomics,genotyping-by-sequencing,otolith,microchemistry,stable isotopes,microbiome,gills parasites,ling
Constantius in Context: Reshaping the Roman Empire (CONSTANTIUS2)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 183504.6
EU funding (EUR): 183504.6
Participants: 1
Project status: CLOSED

The reign of the Roman emperor Constantius II (337–361) was instrumental in shaping early models of a united Europe. Constantius presided over religious controversies regarding the definition of Christian orthodoxy and the role of the state in ecclesiastical affairs, and a substantial reorganization of the political, administrative and military aspects of the empire. His reign shaped the state which was to become the Carolingian empire in the west and the Byzantine empire in the east. In the absence of Constantius’ own writings, the literary source tradition for his reign, represented by secular and ecclesiastical writers, is the most complex and hostile towards a single emperor in Roman history. It is characterised by a range of traditional yet developing literary genres which articulate the religious and political anxieties of their age and have obscured Constantius’ role in this formative period of European history. Using theoretical approaches developed within the field of classical literary studies, this project will investigate: (1) how the presentation and reception of Constantius developed in the source tradition between his accession and the mid fifth century; (2) what the shifting critical framework within which these authors judge Constantius tells us about the changing nature and understanding of the imperial office in Late Antiquity; (3) to what extent the literary presentation of Constantius may be reconciled with information derived from laws, inscriptions and numismatic evidence, which illuminate his overhaul of the administrative and legalistic role of the emperor. The outcomes will contribute to several objectives of the ERA and Horizon 2020. Together with creating intra-European collaborations, the scientific outcomes will provide an enhanced interpretation of Constantius’ reign, an enriched understanding of the literary and cultural contextualization of each source author, and a new, interdisciplinary approach to assessing Late Antiquity.

Keywords: classics,late antiquity,historiography,literary history,literary theory,narratology,intertextuality,early church,panegyric,numismatics,epigraphy.
Bridging length and timescales of Electronic processes in organic SemiconducTor devices (BEST)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 169800.0
EU funding (EUR): 169800.0
Participants: 1
Project status: CLOSED

The development of the next generation of efficient opto-electronic devices based on organic semiconductors relies on the capability of theoretical modelling to shed light onto microscopic mechanisms underneath and provide a rational approach to materials and devices design. To answer this need, we propose the realization of a general multiscale modelling platform, capable to cover and bridge key aspects at core of device functioning, from supramolecular organization to energetics and time evolution of charge and energy carriers. This novel modelling platform will be applied to obtain crucial insights on exciton dissociation and charge separation in bulk heterojunctions, charge transport in doped materials and multiple exciton generation through fission of singlet excitons. A general and efficient computational protocol for the collection of essential information with state-of-the-art and original theoretical tools at the different levels of resolution, and its injection into effective model Hamiltonians, will endow us with an unprecedented comprehensive and realistic picture of electronic structure and dynamics in heterogeneous and disordered mesoscopic systems. Fully accounting for charge and energy carrier delocalization, intermolecular hybridization and quantum superposition of Frenkel and charge-transfer excitations, this approach has the potential to disclose molecular and supramolecular requirements for an efficient ultra-fast multiplication of excitations and their subsequent splitting through hot charge-transfer states, or for the tuning of semiconductor properties by chemical doping. This research will be undertaken in collaboration with leading experimental and theoretical groups, levering the BEST ambitious profile, and strengthening the European excellence in organic electronics research. The involvement in Host-industry partnerships will extend the BEST outreach towards applications, reinforcing the leadership of European high-tech industry.

Keywords: multiscale modelling,organic photovoltaics,singlet fission,molecular doping,molecular dynamics,quantum chemistry,effective model hamiltonians,excited state dynamics
“Boosting the EU ARCTic poliCY: security, sAfety and sustainability” (EU_ARCTYCA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Norway
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-08-01
End date: 2017-07-09
Duration (months): 24.0
Total project cost (EUR): 230943.6
EU funding (EUR): 230943.6
Participants: 1
Project status: CLOSED

The Arctic is subject to major and rapid changes in social and economic systems, ecosystems and environmental processes. With the growing interest of the oil and gas sector in the Arctic, it has become clear that there is a high business development potential for Arctic and non-Arctic institutions and corporations. The EU, which is strictly dependent on the Arctic with regard to the import of natural resources, is greatly aware of the importance of the Arctic for its future generations. Among the main risks connected to growing international interest in the Arctic, there are the contamination and over-exploitation of essential resources by multinational corporations, in need of high quality knowledge for sustainable development. It is against this background that this research proposal, “Boosting the EU ARCTic poliCY: security, sAfety and sustainability” (EU_ARCTYCA) aims at analyzing the EU expanding role in the Arctic and its ecosystem approach to security, safety and sustainability matters in the Arctic, while seeking to deploy its actions related to the EU regulatory framework of corporate environmental responsibility, i.e. corporate commitment to assess business compliance with environmental impact and sustainable development thus assuming responsibility of their business operations.

Keywords: eu arctic policy,security,safety,sustainability,ecosystem approach,corporate environmental responsibility,environmental impact assessment,natural resources management,business operations.
Identifying the targets and mechanism of action of the SUMO targeted ubiquitin ligase RNF4 in response to distinct DNA lesions (RNF4 IN THE DDR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-07-01
End date: 2017-08-19
Duration (months): 24.0
Total project cost (EUR): 309235.2
EU funding (EUR): 309235.2
Participants: 1
Project status: CLOSED

The Ubiquitin (UB) and SUMO modification pathways have recently been shown to be important regulators of genome stability. However, despite their significance, we do not have a detailed understanding of which repair proteins they modify, nor how they promote DNA repair. This proposal aims to address this by studying the human protein RNF4, which sits at the interface between the UB and SUMO pathways. RNF4 is a SUMO targeted ubiquitin ligase (STUbL) which binds poly-SUMOylated chains and ubiquitylates them. To date, very few RNF4 targets are known. I will use a novel approach enriching for hybrid SUMO-UB chains followed by quantitative proteomics to identify the targets of RNF4-mediated ubiquitylation. This work will generate an important DNA damage ubiquitinome dataset which will be a resource for the entire DNA repair community. Equally importantly, I will study the function of RNF4 at distinct types of DNA damage. Most of our understanding of RNF4 function is biased towards its role at DNA double strand breaks (DSBs). However, RNF4 depleted cells are sensitive to a wide range of DNA damaging drugs, indicating that RNF4 functions at other lesions. I will monitor RNF4-dependant ubiquitylation changes in response to ionising radiation, hydroxyurea and camptothecin; conditions that induce distinct types of DNA damage. To gain more mechanistic insight, I will adapt a novel strategy to study the role of RNF4 at two different site-specific DNA lesions in vivo: an induced DSB and protein-DNA adduct. This system will allow me to study how RNF4 affects the recruitment kinetics of repair factors to lesions and how this influences their repair. It will also allow me to target deubiquitinases (DUBs) to test how loss of UB impacts DNA repair. This work could reveal novel DNA repair proteins as well as those acting at specific lesions. As DNA repair factors are targeted in cancer therapy, this work has the potential to lead to the development of novel therapeutics.

Keywords: dna damage,sumo,ubiquitin,e3 ligase,proteomics,mass spectrometry,rnf4 (ring finger protein 4),sumo-targeted ubiquitin ligase (stubl),deubiquitinase (dub),sumo proteases (senps)
Spatial processing under attentional load: from clinical to fMRI evidence (SPACELOAD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Belgium
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-02-01
End date: 2017-05-03
Duration (months): 24.0
Total project cost (EUR): 235000.0
EU funding (EUR): 235000.0
Participants: 1
Project status: CLOSED

Everyday life requires to continuously process the surrounding space to extract behaviourally-relevant information. When attention is loaded, however, this processing might become difficult. This happens, for instance, when space has to be attended while additional stimuli have to be processed in parallel (e.g., talking while driving). In the present project the attentional system will be loaded through visual or auditory dual-tasking to investigate the core cognitive and neural mechanisms subtending normal and pathological (stroke patients) spatial processing. Dual-tasking will be adopted in patients to characterize those subtle post-stroke attentional deficits in the processing of one side of space which often go undetected by traditional paper-and-pencil tests. Patients' behavioural deficits will be matched with specific brain damaged areas by symptom-lesion mapping analyses. Healthy participants will be studied through a brain imaging technique called functional Magnetic Resonance Imaging (fMRI). fMRI will detect the functional changes in brain activation under different attentional load conditions, allowing to isolate task-dependent and load-dependent brain areas. By binding together clinical and neuroimaging techniques, this project aims to strongly contribute to understand the cognitive neuroscience of spatial processing and its normal and pathological limits under dual-tasking. Both the fMRI and the clinical workpackages are expected to provide converging evidence in determining the contribution of specific brain areas while processing space under different levels and types of attentional load. Through this project the applicant will gain a strong expertise in the use of fMRI by joining an excellent cognitive neuroscience lab, embedded within a multidisciplinary context.

Keywords: fmri,attention,spatial attention,attentional load,spatial processing,neglect,extinction,neuroimaging,dual-task,spatial awareness,lesion mapping,neuropsychology,cognitive neuroscience
A Formal Rule-Processing Engine for Privacy-Respecting Forensic Investigation (PRIVACY4FORENSICS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Norway
Call:  (FP7-PEOPLE-2013-IIF, 2013)
Start date: 2015-02-15
End date: 2018-03-04
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 2
Project status: CLOSED

The forensics investigation requirements are in direct conflict with the privacy rights of those whose actions are being investigated. At the same time, once the private data is exposed it is impossible to ‘undo’ its exposure effects should the suspect is found innocent! Therefore, there is a growing concern in the development of forensic investigation frameworks that respect privacy of the involved entities whiles only need-to-know data are exposed to the forensic investigator. To the best of our knowledge, there is no model for privacy-respecting digital forensic investigation that is capable of considering different jurisdictions requirements and protects subjects' data privacy in accordance with search warrant permissions and collected data requirements. In this proposal, we offer development of a rule-processing engine that extracts privacy properties of collected data and investigation search warrant(s), detects conflicting or uncertain situations and labels collected data accordingly, and monitors and controls investigator access to collected data in accordance with the assigned labels. The proposed model is capable of parsing any privacy policy (to support different rules and regulations in different contexts) and labels any type of collected-data while it keeps the soundness of the investigation by not amending the source data. The main contributions of this research are development of a formal language for capturing privacy properties of forensic investigation search warrant and collected data policies, devising objective criteria for comparing and contrasting privacy properties to detect potential conflicts or uncertain situations and making objective rulings, development of a practical strategy for labeling the collected data in accordance with privacy rulings, and innovation of a privacy-respecting forensics investigation controlling and monitoring engine.

Keywords: digital forensics,privacy,formal methods
Laser-Initiated Liquid-Assisted Colloidal Lithography (LILAC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-03-01
End date: 2016-02-29
Duration (months): 24.0
Total project cost (EUR): 299558.4
EU funding (EUR): 299558.4
Participants: 1
Project status: CLOSED

The overall purpose of this research project is to develop and apply a novel laser-initiated liquid-assisted colloidal lithography (LILAC) method for controllable nanostructuring a wide range of surfaces. The method combines, for the first time, ultra-short laser pulses, medium-tuned optical near-field effects and colloidal lithography to achieve surface structuring of materials like Si, III-V semiconductor, biomedically relevant metals and polymer surfaces. The detailed mechanisms underpinning the pattern formation depend on the many experimental process variables: laser wavelength and intensity/fluence; choice of liquid; size, shape, nature and packing of colloid particles; choice of solid surface, etc. Accordingly, the 2-year project proposed here has three interconnected aims: 1. To investigate the mechanisms of the pattern formation by systematic variation of relevant experimental parameters. To this end, we will vary: the nature of the liquid used to produce radical species at the liquid-substrate interface, laser pulse duration and wavelengths, the colloidal lithographic masking strategy, substrate surface chemistry, etc.; 2. To exploit the LILAC method to generate surface patterns with unprecedented physical and chemical sophistication and complexity; 3. To undertake preliminary investigations of the utility of specific surface micro-structures for tissue engineering and sensor applications. This project will help Dr. Magdalena Ulmeanu to embark upon an independent research career and to acquire new practical and theoretical skills necessary for her career development in ultra-short laser processing of surfaces.

Keywords: engineering surface patterns,iii-v compound semiconductor,metal,polymer,ultra-short laser pulses,medium-tuned optical near-field effects,colloidal lithography