Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Nanoscale Analytical Methods to gain insight into the Initiation of Short-Term Memory (NAMISTMem)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-24
End date: 2020-10-23
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

-The aim of this project is to develop novel nano-bioanalytical methodologies to explore a molecular paradigm for the initiation of short-term memory (STM) based on exocytosis events. Despite the vital role in neural disorders such as Alzheimer’s disease, the molecular mechanisms of the initial step in STM formation is still mostly a mystery. Understanding STM initiation at the molecular level requires advanced analytical measurements at the level of attoliter vesicles and the synaptic cleft to monitor individual exocytosis events. This poses an extreme analytical challenge. “NAMISTMem” will develop new strategies for quantitative determination of the entire vesicle content (Objective 1), and will also provide a completely new direction of research that will measure cellular and vesicular changes in chemical endogenous factors (e.g. lipids and zinc) over time following an exocytosis event and will correlate these changes to the molecular initiation of STM (Objectives 2 and 3). These changes, which might alter the neurotransmission process, can be hypothesized to be the initial step that alters synaptic plasticity and commencement of STM. These studies will be developed based on state of the art analytical techniques including in-vivo Nanoelectrochemistry, Secondary Ion Mass Spectrometry (SIMS), NanoSIMS, and Helium Ion Microscopy on model nerve-like cells and simple animal nerve cells (Pheochromocytoma Cell and Drosophila’s brain, respectively). Overall, the proposed methods will have immediate and broad impact in large fields of analytical and life science via pushing the small size limits of bioanalytical probes to achieve a better understanding of the neuron and STM; and will provide innovative analytical approaches for modern brain science discoveries.

Keywords: nanoelectrochemistry,bioanalytical chemistry,mass spectrometry imaging,short term memory
Establishment and Exploitation of a European-Latin American Research Consortium towards Eradication of Preventable Gallbladder Cancer (EULAT Eradicate GBC)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Argentina,Germany,Norway,Bolivia, Plurinational State of,France,United Kingdom,Chile,Peru
Call: Translational collaborative cancer research between Europe and the Community of Latin American and Caribbean States (CELAC) (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-12-01
End date: 2025-11-30
Duration (months): 72.0
Total project cost (EUR): 4675932.3
EU funding (EUR): 4675932.3
Participants: 14
Project status: SIGNED

Gallbladder cancer (GBC) is a neglected disease with huge potential for prevention. This project aims at significantly improving the accuracy of risk estimation and early detection of GBC by identifying and adequately considering geographical, environmental, lifestyle, ethnic, gender and molecular differences. We plan to generate the information needed to establish and refine current prevention programmes, including the primary, secondary and tertiary prevention of GBC. We will (1) build a unique European–Latin American GBC biorepository integrated into a tailored IT platform, (2) identify, validate and functionally characterize novel GBC biomarkers, (3) develop a multifactorial risk score that integrates established and newly identified epidemiological and molecular risk factors, (4) improve the understanding of the causal mechanisms that link lifestyle, cultural and behavioural factors to GBC development, (5) unravel novel opportunities for the targeted therapy of incidental GBC, (6) exploit existing and newly generated epidemiological and multi-omics data to improve the accuracy of GBC risk prediction and (7) contribute to the training of the next generation of Latin American researchers in precision medicine for GBC. The generated information will permit identification of individuals at high GBC risk, guiding surveillance and individual decisions on the possible benefit of preventive gallbladder removal in regions of low and high GBC incidence. Novel data on genomic alterations in incidental GBC will pave the way towards implementation of future clinical trials. The planned European–Latin American GBC biorepository and IT platform will constitute a prime resource for translational research on individualized prevention, personalized early detection and targeted therapy of GBC. The participation in our project of representatives of health authorities, patients and the industry guarantees the efficient incorporation of project results into national health policies.

Keywords: gallbladder cancer,risk prediction,early detection,biomarkers,european cohorts,andean countries,health access,precision medicine,individualized prevention,targeted therapy,data integration
iMoHEALTH: A pan-national collaborative analytics platform for the exploration of population health. (iMoHEALTH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-02-28
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The objective of the IMoHEALTH project is to develop a cloud-based analytics platform for population health data. It will allow users to explore and analyse population health data through an interactive and easy to use interface. Healthcare data analysis has become an integral part of public health policy making, medical research, the development of new treatments and medical innovations. Governments, pharmaceutical industries, insurance companies, medical research groups, hospitals, etc., increasingly use population-based healthcare data as a critical support to both research and decision-making. Citizens are also increasingly keen to learn about the distribution and outcome of conditions which they may be suffering from. However, an affordable, user-friendly platform that brings together population health data from multiple sources and enables it to be easily presented and ‘mined’ for this wide range of purposes does not currently exist. The iMoHEALTH platform will meet this need. The iMoHEALTH platform will use a novel technology to provide easily accessible self-service healthcare analytics to all members of the healthcare and research communities. It will be of use to health care policymakers and commissioners keen to ascertain the needs and health outcomes of their communities; medical research communities wishing to explore the characteristics and outcomes of specific cohorts and conduct a wide range of research; pharmaceutical companies, medical device manufacturers and other industry player wishing to explore their market; and private citizens wishing to explore the health landscape. The end product of the feasibility study will be a realistic business plan for exploitation of the novel IMoHEALTH technology. This will include market opportunity (size, growth, needs), value proposition, commercialization strategy, IP strategy technology/solution description, and financial projections.

Keywords: merdical data analysis
Fast Moving Containers Caming Solutions (FMCONTAINERS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Belgium
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Summary FM or Fast Moving containers The Context Shipping lines trading globally are taking delivery of ever larger container vessels. Consequently there is significant pressure on port operators and other suppliers to improve operational efficiencies and reduce costs so that the desired economies of scale can be materialised. The Problem Current methods of securing and lashing containers on vessels during their voyages require a device (twistlock) which can only be manually applied and removed. This is time consuming and costly for both shipping lines & port operators as well as dangerous for workers. It is also a barrier to the complete automation of container handling terminals. The Solution Remove this manual intervention by removing the need for twistlocks. Our Concept A new design for the standard container so that twistlocks are no longer required and a new type of spreader (the grabbing component) that can handle both our new container design and the current standard ISO containers. The Benefits for shipping lines and container terminal operators: - 10-12% in operational cost savings - Correspondingly faster vessel turn-around times in port (this is very important in view of the size of the larger vessels) - Improved safety in container ports - Increased automation of port operations - The ability to handle both old and new types of container design means there will be a smooth transition in the global container fleet which overcomes the most significant barrier to the adoption of our concept. Project Execution Caming Solutions is a company with four partners. Each partner holds a senior position in the ports and maritime sector with a proven background of success in their particular field. Each partner brings a complementary set of skills required to get the new concept adopted by our industry.

Keywords: innovative solution to replace manually operated twistlocks on containers
Skyrmion-Topological insulator and Weyl semimetal technology (SKYTOP)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Emerging themes and communities
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Belgium,Greece,France,France,France
Call: FET Proactive: emerging paradigms and communities (H2020-FETPROACT-2018-01, 2018)
Start date: 2018-11-01
End date: 2023-04-30
Duration (months): 54.0
Total project cost (EUR): 4508487.5
EU funding (EUR): 4508487.5
Participants: 8
Project status: SIGNED

The overall objective in SKYTOP is to make cross-fertilization between different topological classes of materials to realize devices with intertwined electronic spin and topology. In particular, in this project the aim is to combine two “topological classes”, one existing in real space associated with skyrmions and a second one defined in the reciprocal space associated with topological insulators (TI) and Weyl semimetals (WSM). The project consists of the following technical objectives: 1) Develop thin film TI-technology and exploratory research on topological WSM; 2) Develop a functional TI/Weyl-Skyrmion media platform 3) Demonstrate TI/Weyl-Skyrmion based devices. The main idea is to take advantage of the strong charge-to-spin conversion effect anticipated in TI with strong spin orbit coupling (SOC) to nucleate and control the skyrmion dynamics. SKYTOP proposes skyrmion-based bio-inspired devices and reconfigurable filters with enhanced efficiency and new functionality that could lead to a paradigm shift in ultra-dense low power nanoelectronics. SKYTOP will also expected to open a route for exploitation of the emerging Weyl semimetal materials which are currently being investigated at the basic research level.
Exploiting an unusual polyketide chain release mechanism for production of novel enacyloxin antibiotic analogues (NOVENA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Enacyloxin IIa is a polyketide antibiotic with activity against Gram-positive and Gram-negative bacteria that targets ribosomal elongation factor Tu. It has recently been identified as metabolite of Burkholderia ambifaria AMMD and shown to have clinically-relevant activity against Acinetobacter baumannii, a problematic pan-resistant Gram-negative pathogen. Despite its promising biological activity, enacyloxin IIa has not been used in the clinic, presumably due to stability issues. Preliminary experiments have provided evidence for an unusual mechanism of modular polyketide synthase chain release in enacyloxin biosynthesis, involving intermolecular condensation of an acyl carrier protein (ACP)-bound thioester with the C-3 hydroxyl group of (1R, 3R, 4S)-3,4-dihydroxycyclohexane carboxylic acid (DHCCA). The resulting intermediate undergoes epimerisation at C-1 of the DHCCA moiety. This project aims to explore the ability of the chain release enzyme to catalyse the acetylation of a variety of DHCCA analogues with an acetyl-ACP analogue of the polyketide thioester intermediate. It also aims to identify the enzyme responsible for epimerising C-1 of the DHCCA moiety. DHCCA biosynthetic genes will be deleted in B. ambifaria and enacyloxin analogues, with a stable amide group in place of the labile ester group and other modifications to the DHCCA-derived moiety, will be produced via a mutasynthesis strategy.

Keywords: polyketide synthase,nonribosomal peptide synthetase,specialised metabolism,enzymology
Artificial Intelligence driven topology optimisation of Additively Manufactured Composite Components (AI2AM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Greece
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 165085.44
EU funding (EUR): 165085.44
Participants: 1
Project status: SIGNED

Additively Manufactured fibre reinforced composite (AMC) components manufactured via fused deposition modelling (FDM) rapidly find applications within the European aerospace and transport industry , due to their well-known advantages mainly relating to less machine, material and labour costs, less manufacturing waste, and usage of more efficient materials. A major drawback of AMC components is their usually complex and in cases tessellated geometry; this gives rise to combined (e.g., fibre pull-outs and matrix cracking) and quasi-brittle damage mechanisms that deviate from the usual “high strength and ductile metal” design paradigm. Such a “complexity”, if controlled, can result in components of tailored mechanical properties, e.g., of increased fracture toughness and pseudo-ductile post fracture response. Unfortunately, current analysis and design methods lack the necessary level of refinement, or the underlying theoretical framework indeed, to efficiently address this critical issue. AI2AM aims to deliver a holistic approach to additively manufacture topologically optimum composite components of increased fracture toughness. It will achieve this by developing a state-of-the-art fracture simulation framework for composite structures harnessing the fidelity and computational advantages of phase field modelling for fracture and scaled boundary finite element methods. This high fidelity physics based "continuum toolbox" will be used to train surrogate models based on machine learning methods. The surrogates will then be deployed within a novel topology optimisation framework to deliver optimal and 3D printed geometries. The envisaged methodology crosses the boundaries of computational mechanics, optimisation, and machine learning and brings together a talented academic with world-class experts in topology optimisation, composites, and additive manufacturing.

Keywords: phase field,scaled boundary finite element methods
MRTF/SRF signalling in regulation of cell senescence and melanoma progression (MRTFSen)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Myocardin-related transcription factors (MRTFs) are G-actin binding proteins which act as transcriptional co-activators Myocardin-related transcription factors (MRTFs) are G-actin binding proteins which act as transcriptional co-activators in association with the transcription factor SRF. MRTF-SRF target genes encode numerous proteins involved in actin dynamics, cell adhesion, migration and contractility. The subcellular localization of the MRTFs is controlled by actin binding which inhibits their nuclear import and promotes their nuclear export. Extracellular signals which activate Rho-family GTPases induce actin polymerization and G-actin depletion, which induces MRTF shuttling to the nucleus and transcriptional activation of MRTF-SRF target genes. The MRTF-SRF pathway activation via Rho plays an important role in cancer cell invasion and metastasis. In addition, in MRTF-SRF signalling inhibits cell senescence in hepatocarcinoma cells which present high Rho activity, but this has not been investigated in other cell types or cancer models. Cell senescence is a process of cell-cycle arrest which typically occurs in ageing, cancer, development or tissue repair, and can facilitate recruitment of immune cells. In the tumour microenvironment, senescent cells can direct events such as therapeutic resistance or metastasis that support malignant progression. In this project we will determine the molecular mechanisms by which MRTF-SRF signalling inhibits cell senescence in MEFs. We also aim to investigate the possibility for it to modulate melanoma progression in the BRafV600E mouse model, where senescence is an initial step prior tumour transformation. Increasing evidence suggests that anti- and pro-senescent therapies can be beneficial also in other pathologies, such as fibrosis, by limiting cell proliferation and allowing clearance of damaged cells. These studies have the potential to reveal new approaches to the modulation of senescence pathways for therapeutic benefit.

Keywords: mrtf srf signalling,cell senesce,mechanotransduction,cell adhesion,melanoma,skin tumour,oncogene induced senescence,cell signalling
Hybrid Co-based nanorods for biosensing and catalysis (HyCoRod)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Multifunctional nanostructured hybrids comprising a magnetic component can respond to the growing demands of a large variety of applications, including but not limited to biotechnology (health issues) and catalysis (energy efficiency processes), identified as relevant for the H2020 EU Research and Innovation programe. HyCoRod is a basic research project, aiming at tailoring the physical and chemical properties of metallic ferromagnetic cobalt nanorods (NRs) by combining them with two different metals, each combination targeting a different application domain: (i) cobalt-gold core-shell for in vitro biosensing (by testing a new patented highly-sensitive biosensor) and fundamental magneto-optical studies and (ii) cobalt-iron/iron carbide dumbbells as well as core-shell NRs for the novel concept of magnetically induced catalysis (Fisher-Tropsch synthesis). The multifaceted planned research spans from nanoparticle chemical synthesis within the host group (K.Soulantika-LPCNO, France), to aqueous transfer and biofunctionalization of nanostructures (1st secondment, W.Parak-CICbiomaGUNE, Spain), and biosensing concepts and measurements (2nd secondment, J.Schotter-AIT, Austria) and on catalysis and magnetically induced heating properties assessment (B.Chaudret, LPCNO), issues in which so far the applicant has no experience. Moreover, the candidate contributes to the bidirectional host-applicant transfer knowledge by providing recognized researchers (P.Vavassori-CICnanoGUNE, Spain) in the field of magneto-optical properties, for which the host group is barely familiarized. Overall, the project offers the possibility to the applicant to become not only a more experienced researcher in the field of nanoscale materials but also to gain a prestigious network of collaborations, thus reinforcing her possibilities to achieve a professional scientific position.

Keywords: multifunctional nanoparticles,magnetic,cobalt,nanorods