Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Precision Rayleigh jet sprays (RayleighSprays)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Sprays have a wide range of applications, from cleaning to agriculture to medical treatments. Spray technologies are key to many industrial processes, yet many current spray technologies suffer from insufficient control over the resulting spray parameters, such as the droplet size distribution, even though the drop size critically determines whether a spray reaches its target or not in applications such as pharmaceutical drug inhalation and agricultural spraying. As trial-and-error spray development methods are reaching their limits, we need a new breakthrough to enable perfectly monodisperse sprays. I have previously shown that insights into the physics of sprays can lead to improved spraying and deposition methods. For agricultural sprays I achieved the first detailed understanding of the strongly non-equilibrium processes that underlie spray formation, allowing for a quantitative description of the drop size distribution in these sprays. These insights pave the way to improving our understanding of sprays in general and translating it into a new generation of spray nozzles that produce highly controlled droplet size distributions as urgently needed by a range of applications. The scientific challenge is to identify the complex nonequilibrium physics underlying liquid breakup and use these insights to devise entirely novel ways of controlling instabilities to achieve perfectly monodisperse sprays. We will combine breakthroughs in hydrodynamics to ‘tame’ the instabilities responsible for spray formation, using selective excitation of instability modes combined with novel nanofabrication methods for spray nozzles. In addition, we will study drop coalescence and droplet trajectories in air. We will elucidate spray mechanisms allowing for monodisperse sprays, and explore the role of liquid composition in complex sprays. These fundamental breakthroughs will be tested in precision medicine and agriculture, two of the most important fields of spray use.

Keywords: spray,drop formation,instability,singularities
Unlocking the Antitubercular Mode of Action of Asperterpenoid through Total Synthesis (Asperterpenoid)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 286191.36
EU funding (EUR): 286191.36
Participants: 2
Project status: SIGNED

The rise of multi-drug resistant strains of Mycobacterium tuberculosis, the pathogen responsible for the infectious disease tuberculosis, calls for research into novel antitubercular scaffolds and targets. Asperterpenoid is a rare sesterterpenoid with a unique and highly complex 5/7(3)/6/5 ring-fused carbon skeleton that strongly inhibits tyrosine phosphatase B, a virulence factor protein secreted by M. tuberculosis that aids human host infection. To date, total synthesis of asperterpenoid has not been accomplished. We propose a modular synthesis of asperterpenoid from biorenewable sitolactone using a key intermolecular reductive titanium mediated Giese addition reaction. The scope of this privileged reaction will be expanded by investigating selected epoxide substrates and Michael acceptors. We anticipate that the synthetic strategy to asperterpenoid can be extrapolated to prepare variecolin, a structurally related sesterterpenoid that has been subject of several studies but never reached by chemical synthesis. Based on its structural similarity to asperterpenoid, we expect that variecolin will also exhibit antitubercular activity. We plan to study the known antitubercular activity of asperterpenoid by structural diversification and its mechanism of action by a chemical biology tools such as molecular imaging. We also plan to test variecolin for antitubercular activity. The action is expected to contribute to new synthetic tools and strategies to prepare rare sesterterpenoid natural products, a better understanding of the promising antitubercular properties of asperterpenoid, and to demonstrate that variecolin exhibits similar bioactive behaviour.

Keywords: sesterterpenoid,variecolin,radical chemistry,photo redox chemistry,asymmetric synthesis,chemical biology,tuberculosis,molecular imaging
Controlled Synthesis of Panchromatic Electrochromic Polytriarylamines (COSY-PANTERA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 1
Project status: CLOSED

The goal of COSY-PANTERA is to develop a synthetic route giving access to easy-to-tailor electrochromic panchromatic pi-conjugated polymers that will undergo a clear transparent to color change with high durability, strong color contrast, and fast switching time. To achieve it, I envisage preparing structurally-controlled polymers with multiple redox states (polyelectrochromes) that can be obtained by superimposing individual visible-light-absorbing electrochromes. This is engineered by installing electrochromic moieties (e.g., carbazoles for green and phenothiazines for red) as pendant groups on a blue electrochromic triarylamine-based polymer backbone, known to form stable radical cations upon oxidation. To obtain polytriarylamines with desired structural characteristics, I will develop a novel catalyst-transfer polymerization (CTP) method based on the Buchwald-Hartwig C-N bond-forming reaction. AB-type monomers bearing electrochromic substituents will be prepared and, depending on the CTP protocol, alternate and block co-polymers will be designed. This approach will provide well-defined and reproducible triarylamine-based polymers with tailored characteristics: average molecular weights, narrow molecular weight distributions, end-group fidelity, composition, and color without the use of toxic reagents. Integration of these polymers into electrochromic prototypes will provide feedback to fine-tune the polymer structure, characteristics and electrochromism. As proof-of-concept, I target the synthesis of a panchromatic aimed-at-black triarylamine-based polymer, the most demanded color in electrochromic applications. This fellowship will allow me to continue my training in the field of organic chemistry, expanding my expertise into functional materials and properties assessment, with the goal to shape me from a prime researcher into a full-fledged scientist kicking off his independent career.

Keywords: conjugated polymers,catalyst transfer polymerization,synthetic methodology development,polytriarylamines,chromogenic polymers
Gene expression dosage as a driver of cellular and physiological traits (DOSAGE2FUNC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-07-01
End date: 2027-06-30
Duration (months): 60.0
Total project cost (EUR): 1993059.0
EU funding (EUR): 1993059.0
Participants: 1
Project status: SIGNED

The expression dosage of a gene is a fundamental determinant of its downstream function at the cellular and organismal level, and its genetic or environmental perturbations are a driving force of most common and rare disease in humans. However, we have limited understanding of the specific shape of dosage-to function-curves for human genes, what factors and mechanisms drive their variation across genes, phenotypes and cellular contexts, and how this contributes to functional architecture of human traits. This project addresses these questions using large human genetic data sets and cutting-edge experimental approaches. Using blood cell traits as our study system, we will characterize the relationship between gene dosage and cellular and physiological function in in unprecedented scale and depth. This addresses fundamental questions in systems biology and produces insights that can also benefit genomic medicine and drug development. The Work Packages of this study will: 1) Establish the dosage-to-function relationship for hundreds of human genes, associating genetically driven gene dosage to blood cell traits in large human genetic data, and by an innovative CRISPR-based experimental approach that maps gene dosage changes to multiple cellular phenotypes; 2) Elucidate how cellular the dosage-to-cellular-function relationships differ between cellular states, and use single-cell RNA sequencing to analyze how regulatory networks mediate context-specific dosage-to-function effects; 3) Characterize upstream genomic and environmental regulators of gene dosage. This project will build the first comprehensive, generalizable picture of gene dosage-to-function relationships in humans. Our analysis will link these insights to functional architecture of human traits, providing unique generalizable insights into how disruption of gene dosage and regulatory networks underlies human traits at the cellular and physiological level.

Keywords: complex disease
Sexual conflict in the sexually cannibalistic Springbok mantis (Miomantis caffra) (SCISM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Finland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: CLOSED

Sexual cannibalism, which occurs when a female eats her mate before, during or after mating, is a classic example of sexual conflict since females gain a meal but males lose their life. The risk of premature death is expected to select for cautious mating tactics that help males to secure matings and avoid being eaten. Although such tactics are common in cannibalistic species, males of the Springbok mantis, Miomantis caffra, take a far more aggressive approach, wrestling females to coerce them to mate. Males that win wrestling bouts are more likely to secure matings and avoid cannibalism, but wrestling severely wounds females whose abdomens are punctured by males' weaponised forelegs. While this harmful male behaviour appears to be a classic manifestation of sexual conflict, the exact causes and consequences of male coercion and female injury in this species are yet to be elucidated. My project aims to use field, laboratory, and modelling approaches to investigate the role of sexual conflict in the evolution of cannibalistic and anti-cannibalistic behaviour. First, to determine rates of female injury in the wild, I plan to use mark-recapture techniques to track sex-ratio and injury incidence through time in wild populations of M. caffra in Auckland, New Zealand, where the species is widespread. Second, I plan to run a series of laboratory experiments to explore whether males increase their fitness by injuring females, or whether injury is an incidental side-effect of males' drive to mate. Third, I plan to run a mesocosm experiment to examine whether an increase in the intensity of sexual conflict reduces female survival and population productivity--a key theoretical prediction that has rarely been tested. Finally, I intend to use modelling techniques to investigate, more generally, the role that sexual conflict over mating decisions plays in shaping male and female behaviour in sexually cannibalistic taxa--a relationship that is currently poorly understood.

Keywords: behavioural ecology,evolutionary ecology,population biology,sexual conflict,sexual cannibalism,male coercion,female resistance,sexual injury,praying mantis,individual based modelling
New GeneRation marinE ENgines and Retrofit solutions to Achieve methane abatement flexibilitY (GREEN RAY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Innovation actions
Partnership: ZEWT (co-programmed)
Countries involved: Finland,Netherlands,France,United Kingdom,Belgium,Italy,Norway,Switzerland,Germany,Malta
Call: Assessing and preventing methane slip from LNG engines in all conditions within both existing and new vessels (ZEWT Partnership) (HORIZON-CL5-2021-D5-01, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 10508822.8
EU funding (EUR): 6973122.5
Participants: 13
Project status: SIGNED

LNG utilisation in shipping is increasing and has direct effects namely benefits on air quality and human health. Moreover, CO2 emission is lower with gas use compared to diesel fuels, but ‘methane slip’ may form in gas combustion. The low-pressure dual fuel concept is the most popular LNG engine technology and unfortunately also the technology producing methane slip. Therefore, development of methane slip reduction technologies for these low-pressure dual fuel cases is the focus of this project. To assess the methane emissions from shipping the GREEN RAY project will combine existing data collection with onboard measurements to address existing vessels and new builds, normal operation and varying loads, and further utilise these results in a model development to achieve LNG fleet level assessment. To prevent the methane slip, the strong consortium of GREEN RAY will develop on-engine technologies for low pressure dual fuel engines and aftertreatment technologies for the existing vessels as well as newbuilds. First, the four stroke engine technology is developed further to enable methane slip reduction at all engine loads and to be applicable to the largest engines in the market involving cruise, ferry and gas carriers. Second, the on-engine technology development for the two stroke engine, around a patented LNG injection system, will aim to significantly reduce methane slip from e.g. tankers and container ships. Third, a unique approach of a sulphur resistant catalyst system to significant methane oxidation while also ensuring that the activity remains high over time. The achievements of these three technologies' development will be demonstrated onboard two new builds and one retrofit to existing vessel, all of them targeting TRL 7, and implementing the partnership on ZEWT. Dissemination and exploitation of GREEN RAY results towards acknowledged target groups will enable wide deployment of the new technologies maximising also the benefits for climate.

Keywords: methane slip,ship emissions,lng engines,aftertreatment
ZERo-carbon building enabling Adaptive opaque Facade technology (ZERAF)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Netherlands,Germany,Spain,Portugal
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-02-01
End date: 2027-01-31
Duration (months): 48.0
Total project cost (EUR): 3052336.25
EU funding (EUR): 3052336.25
Participants: 6
Project status: SIGNED

Building market demands high indoor environmental quality but is under the pressure of energy price volatility, European policies, targeting a carbon neutral building stock by 2050, and local building regulations. A drastic carbon footprint reduction on the EU building stock is only possible with: (i) a strong reduction of heating and cooling energy demand and (ii) the limitation of the embodied environmental impacts of building materials. We propose a disruptive facade concept, the ZERo-carbon building enabler Adaptive opaque Facade (ZERAF), to get a huge decrease in the operational energy demand, while reducing the environmental impact of new and existing buildings through novel materials. ZERAF concept enables shifting the opaque building façade systems from being static thermal barriers to thermal modulators. The disruptive configurations of opaque façade technology and the use of novel materials (smart Shape Memory Alloys, and new generation bio-based polyurethanes) enable such a dynamic thermal control. Moreover, ZERAF minimizes the number of primary sources (in terms of volume and diversity) and then of the embodied carbon. ZERAF radically reconceptualizes the adaptive opaque facades concept, taking the opportunity of doing high-risk/low-TRL research in an interdisciplinary environment to bring cutting edge novelties from aerospace, biomedicine, nanomaterials, chemistry and IOT to building sector. The objective is to scientifically prove that ZERAF concept can control all heat transfer mechanisms in opaque building façades to a significant level. Prototypes will be manufactured for the first time and their thermal behaviour will be characterized in a dedicated laboratory coupling a calorimeter and a continuous sun simulator. To prove that used materials, fabrication processes and assembly methods do not jeopardize the carbon footprint reduction, most relevant sustainability parameters will be quantified through a building life cycle method.

Keywords: energy saving opaque facades as thermal modulators smart materials adaptive insulation bio based polyurethanes control algorithms carbon neutrality buildings
IGUANABOT: Bioinspired Multimodal Underwater Robot for Marine Conservation (IGUANABOT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2026-07-31
Duration (months): 38.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 2
Project status: SIGNED

Robotic systems in marine environments could enable high-resolution measurements of ecological processes at extraordinary scales, pushing the boundaries of current methods. The inherent limitations of conventional propeller-based ROV push for robotic systems with multiple modes of locomotion; swimming and benthic locomotion. In order to develop multimodal underwater robotics technology, marine animals with both swimming and benthic locomotion capabilities serve as benchmarks. In this project, a bioinspired underwater vehicle called IGUANABOT, inspired by marine iguanas, will be developed with swimming and benthic legged locomotion capabilities. The objectives of the project are to; design and build the iguana-inspired robot, evaluate the robot's performance in the laboratory and the field, and do a case study by creating a 3D map of the seafloor that will aid in marine conservation. These three objectives translate to six work packages: multimodal locomotion system, vision system, integration and control, verification and validation, and a case study. IGUANABOT will be the first underwater robot with unique technological features; bioinspired swimming and legged locomotion in the natural marine environment, a bendable back that adapts to irregular terrain and enhances locomotion performance, and clawed feet that adhere to steep, slippery substrates. The robot’s development and performance optimisation will be performed at Swedish Maritime Robotics Centre, KTH Royal Institute of Technology, Sweden. The case study will take place at the sea close to Gullmarsfjord, a natural reserve in Sweden, stationing at Kristineberg Centre for Marine Research and Innovation, University of Gothenburg.

Keywords: robotics,bioinspiration,marine robots,remotely operated vehicles,swimming locomotion,legged locomotion,multimodal locomotion,marine conservation,3d mapping