Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Revealing Extinction Risk through Comparative Genomics and Artificial Intelligence (REVEAL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark,Germany,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 247553.28
EU funding (EUR): 247553.28
Participants: 3
Project status: SIGNED

Understanding species extinction risk is a crucial goal in Evolutionary Biology and a contemporary societal challenge. The standard method for assessing extinction risk, the IUCN Red List, focuses on external threats and overlooks genetic factors. Despite some weak and variable correlations, genetic diversity offers insights beyond the Red List, potentially resulting in an underestimation of extinction risk. Genomic data, generated rapidly through initiatives like the Bird 10,000 Genomes Project, has the potential to enhance assessments by revealing historical population demography, genetic diversity, and the genetic load of deleterious mutations. Recently, there has been excitement about the potential of reference genomes in conservation genomics. However, the actual potential and limitations of single reference genomes in informing conservation strategies remain unexplored. To address this gap, I propose a comprehensive approach, REVEAL, which integrates comparative genomics and individual-based simulations within a robust Artificial Intelligence (AI) framework. The proposal comprises three steps: (i) simulating extinction risk using a broad parameter space with a dataset of at least 3,825 bird genomes generated by the B10K consortium, (ii) training AI models to recognise genomic signatures associated with extinction risk, based on the previous simulations, and (iii) evaluating the potential and limitations of single reference genomes for extinction risk assessment, using the trained AI models. In particular, I will focus on avian species with diverse geographic ranges and ancestral population sizes in order to compare extinction risk predictions, considering both spatial dynamics and temporal dynamics. REVEAL seeks to move beyond conventional assessments and improve our understanding of extinction risk evaluation using genomic data, ultimately enhancing our ability to formulate effective species recovery strategies.

Keywords: comparative genomics artificial intelligence conservation conservation genomics simulations genomic erosion reference genomes bird genomes
Melanosomes as cancer immune modulators: a novel paradigm in melanoma immunity (melanosomeEVimmune)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2515625.0
EU funding (EUR): 2515625.0
Participants: 1
Project status: SIGNED

Despite remarkable progress in treating melanoma, the most lethal of human skin cancers, 50% of patients are treatment-resistant, with most experiencing disease recurrence. Our recent unpublished clinical and experimental findings uncover new, yet to be explored, melanosome contributions to cancer immunity unique to melanoma. Melanoma retains, for mostly unknown reasons, the ability of its origin to produce melanosomes, lineage-specific large extracellular vesicles (EVs) containing melanin. Surprisingly, our preliminary findings indicate that melanosomes bind and block T-cell activity in a T-cell receptor/antigen-dependent manner; melanosomes carry a neoantigen signature that is distinct from their cell of origin; and can be recycled by stoma cells, with each type endowing the melanosomes with a distinct signature, which may modulate, upon engulfment by macrophages, the latter’s phenotype in relation to melanoma. Given our novel findings and body of literature that strongly suggest an immune role for melanosomes, we here propose to comprehensively explore, for the first time, melanosomes’ effect on melanoma immunity in three directions: melanosomes’ interaction with T-cells (Aim 1), influence on melanoma immune recognition (Aim 2) and interaction with macrophages (Aim 3). This will be achieved by a strong research framework involving new experimental tools, fresh human samples, and cutting-edge in-vivo, molecular, cellular and computational models. While of tremendous complexity and scale, this project is set to offer new perspectives on melanoma progression and response to therapy. Further, our novel EV concepts will greatly advance the EV field and can also be applied to other physiological systems. Our project will also offer the scientific community new experimental tools and omics data on melanoma EVs and immunity. Finally, our project will provide new potential therapeutic means to overcome melanoma immunotherapy-resistance and block melanoma progression.

Keywords: melanoma,melanosome,extra cellular vesicles,melanin,pigmentation
Assessing Carbon Emission Impacts of Circular Economy Measures for Construction and Demolition Wastes in the European Union (CECECDW)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

The EU's circular economy (CE) initiatives, which encourage material recovery and recycling, would inevitably affect the trajectory towards EU's goal of Net-Zero carbon by influencing material and energy flows. Ideally, the CE of construction and demolition waste (CDW) could yield substantial carbon savings by fulfilling the material demand in the building and infrastructure sector with reduced emission-intensive material production activities. However, the adopted CE measures may also affect carbon emissions through indirect channels. For example, the CE of CDW exhibits an economy-wide impact on several emission-intensive industries, including transportation, power generation, and manufacturing, among many others. Given the complexity of the material and energy flows, a comprehensive and systematic understanding of the carbon emission impacts of CE of CDW is essential for policymakers and enterprises to promote climate neutrality and efficient CE management. In this context, this proposed research aims to assess the carbon emissions (or savings) potential of the EU's CE measures for CDW using an environmentally extended input-output (EEIO) model coupled with updated evaluation parameters from a developed LCA model. The EEIO model, considering the diverse industrial mix in EU member states, can characterize how the CE of CDW affects carbon emissions across different industries and regions. By conducting rigorous empirical analysis and refining the modeling of complex material and energy flows, this research will uncover the gravity of the issue and inform policy frameworks, contributing to the EU's strategic environmental objectives and its path to Net-Zero Carbon.

Keywords: circular economy construction and demolition waste input output analysis life cycle assessment carbon emissions
Information processing in passive elastic structures (INFOPASS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 1686875.0
EU funding (EUR): 1686875.0
Participants: 1
Project status: SIGNED

Smart devices constantly monitor the environment and analyse the resulting stream of information, waiting for wake-up events ranging from a skipped heartbeat in a pacemaker to a verbal command in an intelligent speaker. In electronic devices, such constant workload requires reliable power and leads to significant battery drainage. The aim of INFOPASS is to answer the need for zero standby power, always-on sensing and processing, by inventing novel components based on architected elastic microstructures. We will focus on passive speech recognition: Vibrating structures that respond with large amplitudes only when excited by a particular spoken word. The components will be based on artificial neural networks of mechanical resonators -- benefiting from their ultra-low power dissipation and bypassing the inefficient transduction between acoustic and electric signals. The goal of passive speech recognition is challenging due to the required device complexity. Conventional micromechanical systems consist of a few resonators, while neural networks require thousands of nodes, pushing the limits of design and fabrication technologies by orders of magnitude. The proposed work builds on my invention of a two-step structure design method: Advanced responses are engineered by first encoding the desired response in an effective mass-spring model, which is then translated into a structural geometry. Compared to full-wave simulations, mass-spring models speed-up the optimisation process by more than a thousand-fold, allowing us to 'train' the structures on realistic speech corpuses. The invention of devices that passively perform complex information processing tasks will lead to mobile devices with longer battery life, always-on Internet-Of-Things devices that consume no standby power, and battery-less health monitoring sensors ? potentially impacting billions of devices.

Keywords: physical computing,artificial neural networks,intelligent systems,solid mechanics,structural dynamics,nonlinear dynamics,metamaterials
EUROPEAN DEVELOPMENT OF A FIRST COMMERCIAL BIONIC VESTIBULAR IMPLANT FOR VESTIBULAR DYSFUNCTION - 2 (BionicVEST-2)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Belgium,Spain,Netherlands,France
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 2498937.5
EU funding (EUR): 2498937.5
Participants: 6
Project status: SIGNED

In this project we present a solution to restore balance and prevent falls through vestibular implantation and electrical stimulation of the otolith organ. Worldwide, about 684.000 individuals die from falls each year and 37.3 million falls require medical attention. The medical cost for treating falls in the EU is approximately 25 billion euros each year. This number can be expected to go up since the elderly population is growing. One of the most important causes of falling is vestibular dysfunction. Therefore, restoration of the vestibular function may revolutionize this field because it offers a whole new treatment paradigm. The foundation of vestibular dysfunction treatment was laid during the Bionic\VEST H2020 FET-OPEN project funded by the EU. This FET-OPEN project obtained spectacular results and showed that the successful restoration of vestibular function through electrical stimulation of the otolith organ is possible. Where there was no suitable treatment before, balance improvement and even restoration is feasible. The result of this first Bionic\VEST FET-OPEN project was a proof-of-principle on humans with a prototype otolith vestibular implant. To unlock the full commercial potential of this vestibular restorative therapy, the new Bionic\VEST-2 project will focus on the path to commercialization of the Bionic\VEST implant. This requires improvements in the implant technology to achieve its full potential on the market. A pivotal clinical trial will have to be run with the new device to provide evidence for the safety and efficacy of the final implant, as well as gather data for health economics. Further, novel diagnostic clinical tools will be developed to identify the patients that can benefit from this technology promptly. In-depth market research and an elaborated business case should confirm that the vestibular implant will bring the long-awaited solution for vestibular disorders and ameliorate the enormous societal impact of this problem.

Keywords: vestibular implant fall prevention elderly falling vestibular dysfunction otolith organ balance posture gait active implantable medical device neuromodulation
COMPLETION OF FIRST IN HUMAN STUDY AND PH.2 READINESS FOR IBC-AB002 IN ALZHEIMER’S DISEASE (IBC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 20.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

ImmunoBrain Checkpoint (ImmunoBrain) is a private, clinical-stage biopharmaceutical company, committed to developing innovative immunotherapies for neurological disorders. We are at the forefront of developing immune checkpoint blockade as a novel therapeutic approach for Alzheimer’s disease and other neurodegenerative diseases. This innovative strategy stems from discoveries by our co-founder and CSO Prof. Michal Schwartz, highlighting the pivotal role of systemic immune cells in brain health and repair. This pioneering therapeutic approach not only addresses disease symptoms but also augments fundamental mechanisms of brain protection and repair that are compromised with aging and neurodegeneration. We have initiated our First in Human clinical study in early 2023 in 11 clinical sites in the Netherlands, Israel and the UK. It is a Phase 1b study testing our proprietary immune checkpoint antibody, IBC-Ab002, on persons with early and mild Alzheimer's disease, designed to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of IBC-Ab002 across multiple ascending doses. The study's combined Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) design intends to establish dose-related safety, demonstrate biomarker evidence of target engagement, and provide preliminary evidence of disease-modification potential. ImmunoBrain is seeking EIC funding in order to complete the MAD portion to obtain the necessary clinical data that will allow us to engage with investors and partners for Phase 2 financing and/or collaboration.

Keywords: alzheimer s disease,neuroimmunology,neurodegeneration,immune checkpoint inhibition,biologic therapy
AI-driven materials development platform to scale applied materials science for sustainable packaging solutions (one.five)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

one.five is an AI-driven materials development and scale-up platform, providing truly circular packaging solutions with measurable impact to the consumer packaged goods industry to transform the industry within the next decade. Plastic use continues to rise, causing environmental issues globally. Plastic packaging constitutes 40% of total plastic waste, with 22% escaping recycling systems and harming ecosystems. Future projections indicate a doubling of plastic production in 15 years. Manufacturers face challenges with new laws holding them accountable for product disposal. The EU plans to extend regulations, forcing corporations to adapt to consumer demands and regulations. However, sustainable packaging alternatives face scalability issues due to expensive and immature technologies. We are building an AI-driven, materials-agnostic, development platform that discovers and assesses material innovations to enable the fast, cost-efficient, and effective development of novel packaging solutions that will generate immediate positive environmental impact and financial impact for our customers. Our platform, called Quartermaster (in short: Q.), is unique in the market, collects data throughout the development cycle, enabling more accurate evaluation of a product's success likelihood. Our modular, AI-led platform, custom-built with modern technology, accelerates development from 3 years to <30 days and reduces the budget from <250k EUR to <50k EUR by efficiently collecting, storing, and sharing insights from our internal product development process. We are currently raising a 12m EUR series A funding to ensure a 24-month runway, and we are considering a potential 30M EUR series B in Q1 2026. Over the next three years, our key milestones include improving accuracy within our generative AI platform, taking initial steps towards international expansion beyond the EU, enhancing on-site infrastructure and reaching break-even in 2025.

Keywords: circular packaging solutions,materials science,sustainability
MANIC Copper Technology - A Sustainable Way to Make Copper (MANIC CT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: South Africa
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2490000.0
EU funding (EUR): 2490000.0
Participants: 1
Project status: SIGNED

MANIC Copper Technology (MCT) is a forward-thinking visionary privately owned business committed to contributing to a sustainable future of the metals and mining industry focusing on the enhancement, development, commercialization, and deployment of innovative, energy-efficient, and environmentally friendly copper production technologies with the potential to disrupt the copper industry globally. The copper market is a vital component of the global economy, as copper is a versatile metal that is used in a wide range of applications across many different industries, including construction, electronics, transportation, and renewable energy. The clean energy transition is a key demand driver for copper as it is a crucial component in renewable energy technologies such as wind turbines, solar panels, and electric vehicles. At the same time, the grade of copper ore globally is declining, which results in increased production costs and decreased production. The challenges facing copper miners and copper producers have prompted academic community and innovators around the world to look for new ways to increase the economically viable copper resource base and to produce copper metal more sustainably. MCT contributes to addressing and solving the current challenges in the copper industry by prototyping, demonstrating and commercially deploying its unique novel copper making technology. The MCT technology innovations will not only improve on current metal production practices but also allow for the exploitation, beneficiation of otherwise uneconomical resources and rehabilitation/cleanup of the historically accumulated mining waste. MCT has developed a turnkey copper metal making plant designed to have negligible GHG emissions and minimal clean liquid waste. Making metal at the mine/resource is a core technical design philosophy of MCT.

Keywords: critical minerals,copper making,sustainable metal
A revolutionary SmartNIC solution offering unmatched network efficiency experience (DYNANIC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Czechia
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2480000.0
EU funding (EUR): 2480000.0
Participants: 1
Project status: SIGNED

With the emergence of Smart Edge and the advancing 5G & 6G networks, and rising cyber threats, the network data complexities require a new generation of innovative solutions. It is a practical end-to-end solution that leverages the power of parallel processing via FPGA technology, enabling a significant reduction in server load and CPU core usage. This advancement is beneficial for data center owners, telco providers or cybersecurity companies in usage scenarios requiring high-speed data processing, particularly as network data volumes, link speeds, and cybersecurity needs escalate. Hence, DYNANIC aligns with the EIC’s Challenge of enabling smart edge and quantum technology components. DYNAMIC allows scaling throughput in a single pipeline without the need to increase frequency due to fine-grained parallelism and optimized hardware processing. It is thus possible to achieve Tb/s throughput with significantly fewer hardware resources. Now at TRL 6, DYNANIC offers remarkable results in energy-efficiency, scalability, versatility, and advanced security features. The solution offers wire-speed packet processing at speeds of over 400 Gb/s and energy savings of at least 60%, while being compatible with cards from all top manufactures. Targeting the rapidly growing and high-potential programmable NIC sector of the SmartNIC market, DYNANIC’s TAM will grow to €6.4 billion at an 18% CAGR by 2026. Within this, the SOM for DYNANIC is estimated to be €129 million in 2026. Operating a scalable licensing business model, DYNANIC charges based on network interface speeds and card volumes, allowing customers to scale over time. In future, BrnoLogic envisions the scaling up of the DYNANIC solution from one based on FPGA technology to a highly optimized SmartNIC solution offered with own custom chips. The ambition is to compete, by expanding the offering to own custom chips, with market giants like NVIDIA, Intel, and AMD.

Keywords: fpga,smartnics,network speed processing,data,accelerator cards,low latency,5g,6g,smart edge,cybersecurity,network traffic acceleration,dpdk,asics,hardware acceleration,pipeline