Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Ground-breaking two-phase cooling solution for Electrical and Hybrid Vehicles (ALTOM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

ALLATHERM is a Spanish company dedicated to the development of services and products for thermal management systems for a wide range of applications in the energy, scientific, telecommunication, automotive, aerospace, and defence industries. Over the last two years, ALLATHERM has developed ALTOM, a hermetically sealed closed 2-phase heat transfer loop for electronic components cooling. ALLATHERM has taken the 2-phase spacecraft thermal control concept and brought it to terrestrial vehicles with a modular ground-breaking approach. ALTOM is an efficient (fully passive), standardised, flexible (multiple configurations), cost-effective (>400€saved per vehicle), robust (no moving parts) and non-toxic system that manages thermal control in power electronics for terrestrial applications (electric and hybrid vehicles-EV/HEVs-). According to the IEA, EV/HEVs stock is projected to reach 200 Million units by 2030. To achieve these numbers, EV/HEVs powertrain manufactures are required to increase the efficiency, lower cost and standardise their thermal management systems for the electronic components (engine, batteries, and invertor). ALTOM heat loops, which have already proven its capacity to solve all these needs, will reach the market by 2020 selling 65,000 units and generating a profit of 11.7M€ during the first 5 years. ALTOM will directly target EV/HEV and powertrain manufacturers’ needs all across Europe since their market is not focused on a specific geographical area. With ALTOM market launch we will contribute to the achievement of 60% emission reduction in transport within the European Union by 2050, targeted in the 2011 Transport White Paper. Moreover, ALTOM boosts Europe´s transition towards a circular economy as it is framed in the “end-of-life vehicles”, “batteries and accumulators” and “waste on electrical and electronic equipment”, encouraging global competitiveness and sustainable economic growth.

Keywords: two phase,cooling,thermal management,heat loops,electric vehicles,hybrid,spacecraft,electronics,batteries,engine,transport,efficient,modular,standard,flexible,evaporator,powertrain
Genetic basis of herbivore-induced physiological canalization. (HECAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

Herbivores can interact with each other indirectly via the shared host plant, for instance via the induction of plant defenses. Indirect plant-mediated interactions strongly influence herbivore behavior and performance and shape plant-associated arthropod communities. The order of herbivore arrival is often critical for the outcome of plant-mediated interactions, yet the underlying mechanisms remain largely unknown. Diabrotica virgifera virgifera, a specialist belowground herbivore of maize, refuses to feed when a plant is already attacked aboveground by the specialist leaf feeder Spodoptera frugiperda. This host-avoidance behavior is attributed to changes in root-emitted volatiles upon leaf herbivory, in particular the increased production of a nitrophenol (“NP1”), which was not previously known to be synthesized by plants. However, D. v. virgifera suppresses the leaf-herbivory-induced production of NP1 when it arrives on the plant first, and hence, keeps on feeding. HECAN will investigate the genetic and biochemical bases of NP1 biosynthesis in maize in order to understand how the production of NP1 is suppressed by D. v. virgifera.

Keywords: plant mediated interactions between herbivores,maize,leaf herbivore,root herbivore,root volatiles,secondary metabolite biosynthesis
Entanglement in Strongly Correlated Quantum Many-Body Systems with Ultracold Atoms (EntangleUltraCold)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-08-01
End date: 2024-07-31
Duration (months): 60.0
Total project cost (EUR): 1787564.0
EU funding (EUR): 1787564.0
Participants: 1
Project status: CLOSED

Entanglement plays a central role for strongly correlated quantum many-body systems and is considered to be the root for a number of surprising emergent phenomena in solids such as high-temperature superconductivity or fractional Quantum Hall states. Entanglement detection in these systems is an important target of current research, but has so far remained elusive owing to the fine control required and high demands on statistical sampling. The goal of this project is to realize strongly correlated quantum systems close to the ground state using quantum annealing of ultracold fermionic atoms, and to study the character, strength and role of entanglement. We will construct a novel type of cold atom experiment, which makes use of optical tweezers and Raman sideband cooling. This will allow a 100-fold improvement in the experimental repetition rate compared to conventional experiments and allow reaching the ground state in systems of up to 7x7 sites. The flexibility of the moving optical tweezers will facilitate implementing entanglement measures, including concurrence, quantum-state tomography and entanglement entropy. Our primary research objective is studying entanglement in the doped Hubbard model, where a variety of strongly correlated systems are expected, as well as the role of entanglement in thermalizing out-of-equilibrium samples. In a later stage we will focus on frustrated systems in triangular lattices and honeycomb geometries, and also interacting topological states. Our experiments will have a far-reaching impact on condensed matter research, as it will be the first platform for experimental exploration of the role of entanglement in strongly correlated fermionic many-body systems. Our insights will be beyond the capabilities of numerical simulations and we envision that the project will lead to a better understanding of complex quantum phenomena, and may ultimately drive the discovery of novel quantum materials.
Integrated Implant Technology for Multi-modal Brain Interfaces (IntegraBrain)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany,United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 1496000.0
EU funding (EUR): 1328536.94
Participants: 3
Project status: SIGNED

Bioelectronic medicine may soon replace systemic drugs for treating some chronic conditions. The clinician will implant a miniature laboratory to deliver and coordinate a multi-modal treatment program directly at the affected tissue. The technology to bring this vision to the clinic is not yet available. The IntegraBrain project will contribute by building an implantable network of sensors and actuators. Actuators will deploy electricity, light, drugs and thermal energy as modalities of the therapeutic program, while sensors will monitor its progress. A key technological advance will be a method for direct writing of the sensor-actuator network. To achieve this, we will develop a palette of functional inks where each ink supports one of the therapeutic modalities. The technology has the potential to be tailored for applications in soft tissue organs, especially in the nervous system, where injury or degeneration can result in chronic disability. We will apply IntegraBrain technology in two niches of the nervous system in rodents. In the central nervous system, we will demonstrate seizure control by multi-modal neuromodulation. In the peripheral nervous system, we will demonstrate reversible block and excitation. For the first time, we will observe if multi-modal neuromodulation leads to synergistic effects on the nervous system. With the IntegraBrain project, we hope to catalyse pre-clinical development of implantable human-machine interfaces for therapeutic applications.

Keywords: bioelectronics,implant,multi modal,neuromodulation
A skin substitute optimised using mechanobiological simulation to restore weight-bearing function (SKIN-REGEN-MECH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2024-01-30
Duration (months): 24.0
Total project cost (EUR): 196590.72
EU funding (EUR): 196590.72
Participants: 1
Project status: TERMINATED

Large or chronic wounds affect 4 million people in the EU each year. Tissue engineered skin substitutes offer the potential to enhance the repair and regeneration of these wounds. However, there are currently no skin substitutes that can fully restore the weight-bearing function of foot skin. Therapies to reconstruct the foot sole are urgently needed, with an increasing prevalence of diabetic foot ulcers that cost the EU €4 billion annually and have a five-year survival rate as low as 29%. Native skin’s load-bearing structure is dynamic and adaptable to changes in its mechanical environment. By studying the mechanical forces that lead to robust native skin, we can enhance regenerative therapies. The aim of this project is to enhance skin substitute design by optimising its properties using mechanobiological simulation, providing the basis for site-specific skin regeneration that targets weight-bearing function. The specific objectives of this project are: 1. To quantify cell-level mechano-regulation processes in human skin. A dynamic bioreactor will be designed to control the mechnical environment of human skin explants while the cell-level biological responses to load are quantified. 2. To optimise the mechanobiological properties of a skin substitute. A multi-scale computational model of skin mechano-regulation will be developed and used to predict the optimal mechanical and morphological properties for skin regeneration. 3. To demonstrate that this optimisation leads to enhanced dermal substitutes. The optimised skin substitute will be fabricated using bioprinting and micropatterning methods. This substitute will be tested in vitro for its ability to promote robust epidermis formation. This proposal involves substantial knowledge transfer, with the candidate gaining expertise in biomaterials and regenerative medicine, while providing the host with computational modelling and skin biology expertise. This proposal will enhance and broaden the candidate's career.

Keywords: skin substitute,mechanobiology,surgical implant,wound healing,foot ulcers,agent based modelling,computational biology,biomechanics,mechanoregulation,in silico,in vitro,ex vivo,skin injury
Comprehensive experimental and computational mechanical characterisation of metastatic vertebrae (METASPINE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Lytic spinal metastases are frequent in cancer patients and can weaken vertebrae, increasing the risk of fracture and leading to spine instability. Qualitative scoring systems are used by oncologists and orthopaedic surgeons to decide if the metastatic vertebrae need to be surgically treated. However these guidelines are not accurate for all those patients with middle-size lesions. An accurate, quantitative and mechanistic computational model would improve the prediction of the risk of fracture in these patients. However, such models need first to be validated against well-controlled expertiments in the laboratory. METASPINE will deliver for the first time a method to comprehensively understand the effect of the properties of bone lesions on the mechanical competence of metastatic vertebrae. In this project, lytic defects will be experimentally reproduced in the vertebrae, which will be tested under multi-axial loading conditions in order to evaluate the effect of the lesions on the displacement and strain fields distributions. A combination of state of the art in situ mechanical testing, microCT imaging and Digital Volume Correlation will be used. Simultaneously, subject specific clinical CT based finite element models of the metastatic vertebrae will be generated, validated against the experimental data, and used to simulate scenarios which cannot be reproduced experimentally. The applicant (Dr Marco Palanca) is a research fellow in the field of experimental spine biomechanics. He will apply his experimental skills to optimise the sample preparation, and mechanical testing. Moreover, the supervision, mentoring, and training provided by the host organization (University of Sheffield, Dr Dall’Ara and Integrative Musculoskeletal Biomechanics group) on imaging and subject-specific finite element modelling will complete his profile as a bioengineer with a specialization in tumour and spine biomechanics.

Keywords: bone,finite element analyses,mechanical test,computed tomography,spine,metastasis,experimental strain analysis,digital volume correlation
From Demos to Ethnos: Popular Revolt and Elite Transformation in Montenegro's Anti-Bureaucratic Revolution (1988–1990) (DEPRET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-09-14
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: SIGNED

With populism, ethnonationalism, and right-wing radicalism on the rise around the globe, the analysis of the Anti-Bureaucratic Revolution in Montenegro (1988–1990) provides unique empirical material to understand how and why an inclusive and tolerant society (demos) can be rapidly transformed into one based on a more exclusive and intolerant ethnic identity (ethnos). DEPRET’s objective is to understand under what conditions civil society turns “uncivil”. It proposes to do so by taking an interdisciplinary approach to investigating two interrelated processes: popular revolt and elite transformation. More specifically, the project aims to: (1) improve understandings of elite transformation through a critical interpretation of elite public discourses, with a particular focus on how they articulated, framed, and legitimized themselves and “the people” to bring about what they saw as “necessary changes to the system”; (2) identify, map, and analyze repertoires of contention and tactics of resistance used by protesting citizens in advancing or resisting right-wing populism, with a particular focus on key grievances, frames, and justifications used to reconstitute themselves from a socialist demos into a nationalist ethnos or to oppose this process; and (3) contribute to theory development by investigating the relationship between grassroots and elite expressions of right-wing populism as a two-way process of elite–mass interaction during turbulent times. To achieve these objectives, DEPRET uses a mixed-method research framework that combines two methods of textual analysis: the qualitative approach of Critical Discourse Analysis (CDA) and the quantitative approach of Protest Event Analysis (PEA) to analyze publicly available textual corpora in Montenegrin libraries and archives. The proposed research conducted within the MSCA-IF framework will significantly contribute to my academic growth from an early-career researcher to an established interdisciplinary scholar.

Keywords: anti bureaucratic revolution,social movements,contentious politics,civil society,montenegro,postsocialist transformation,southeast europe,populism,ethnonationalism
Self-healing on natural hydraulic lime mortars (HeaLime)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Portugal
Call: Widening Fellowships (H2020-WF-02-2019, 2019)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 147815.04
EU funding (EUR): 147815.04
Participants: 1
Project status: CLOSED

Most of the civil and architectural heritage is built with masonry structures. The interventions on such structures require the usage of compatible materials such as natural hydraulic lime (NHL) mortars that offer a promising solution due to their large compatibility with original materials in terms of chemical, physical and mechanical performance. Furthermore, these interventions demand to be as durable as possible and in this sense, the self-healing capacity of NHL mortars seems to be of potential value. HeaLime will create a new testing method to measure self-healing in cementitious materials. It will also characterize systematically a combination of several variables in the context of the performance of the healing capacity. The project will be performed mainly at University of Minho, Portugal, under the supervision of Prof. Lourenço, one of the most prestigious researcher in masonry components and Dr. Azenha, whose proposed methodology of EMM-ARM has involved a revolutionary step in the characterization of the stiffness evolution of cementitious materials. For the purpose, a new testing method will be developed by adapting the technique of EMM-ARM to the measurement of self-healing of NHL mortars in service. At the same time, different materials (such as micro-fibres, crystalline admixtures and superabsorbent polymers) will be combined to create improved NHL mortars for self-healing. Moreover, two secondments will be performed. The first one at University of Ghent, with Prof. De Belie, a leading specialist on self-healing materials, and at Kerakoll, a non-academic institution devoted to the commercialization of sustainable building materials. Finally, a series of pilot demonstration tests will be approached to study the applicability of such improved NHL mortars to building sites. HeaLime will redound in more sustainable and durable repairing operations when approaching the different interventions of the civil and architectural heritage.

Keywords: natural hydraulic lime mortars,self healing,building heritage,fibre reinforced lime mortars,crystalline admixtures,superabsorvent polymers,industrial constrains,applicability to real structures
Paediatric Inflammatory Bowel Diseases Network for Safety, Efficacy, Treatment and Quality improvement of care (PIBD-SETQuality)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Israel,Germany,Italy,Belgium,Belgium,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Establishing effectiveness of health care interventions in the paediatric population (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2021-06-30
Duration (months): 66.0
Total project cost (EUR): 5996000.0
EU funding (EUR): 5996000.0
Participants: 15
Project status: CLOSED

The incidence of paediatric onset Inflammatory Bowel Diseases (PIBD) has risen dramatically in recent decades. Compared to adult forms, PIBD reflects a more severe disease, more often requiring aggressive treatment with immunomodulators, and thereby exposing children to a life-long risk of serious disease and treatment-related adverse events, such as infections and malignancies. Therefore, there is an urgent need to develop strategies which balance, on an individual basis, therapeutic effectiveness with risks of treatment. The overall goal of this proposal is to develop and validate a treatment algorithm for PIBD based on high or low risk predictors for early complicated or relapsing disease. This will improve effectiveness, while reducing treatment related risks and life-long complications due to uncontrolled disease progression. To attain this goal 3 specific aims are proposed under the umbrella of an international network, the "PIBD-net": 1) Development of an accessible and feasible risk-stratified treatment algorithm for new onset paediatric IBD on an existing inception cohort and validation in an independent cohort 2) Generation of a prospective large longterm real world inception cohort in a registry designed to analyze effectiveness and safety signals and correlate them to individual risk factors 3) Design and performance of a risk algorithm-based prospective large-scale multicenter randomized clinical trial (RCT) (stratification into high or low risk groups based on specific aim#1) in order to provide optimal personalized therapy : low risk azathioprine vx. methotrexate, high risk : methotrexate vx. adalimumab This project will translate into the first risk-stratified PIBD treatment algorithms allowing optimization of medical therapy while minimizing treatment-related risk (personalized medicine).

Keywords: crohn s disease,inflammatory bowel disease,risk stratification,safety,efficacy,immunomodulators,thiopurine,methotrexate,anti tnf agents,registry,data base