Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
High Efficiency Access Solution for the Internet of Things (HEASIT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: France
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-2-2015, 2015)
Start date: 2016-03-01
End date: 2018-03-31
Duration (months): 25.0
Total project cost (EUR): 1691226.25
EU funding (EUR): 1183858.38
Participants: 1
Project status: CLOSED

GreenWaves Technologies’ strategy is to offer a high-data-rate radio interface, Green-OFDM, to LPWAN networks. Green-OFDM brings a significant cost advantage and more autonomy than Wi-Fi and LTE alternatives, while maintaining the existing network architecture and functionalities of LPWANs, which neither Wi-Fi nor LTE can do. There is a consensus among experts regarding the explosion in the number of connected objects in the coming years and certainly a speculative inflation. The company’s core strategy is to boost the transfer speeds of LPWANs from 10 kbit/s to few Mbit/s, upgrading them to high-data-rates networks.

Keywords: internet of things,lpwan
Impact of Intrapartum Antimicrobial Prophylaxis as an early determinant in Microbiome Development (IAPEMIDE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-01
End date: 2019-07-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

During the last decades, changes in diet and lifestyle have increased the risk of non-communicable diseases in the western countries. It is known that once they are established in the childhood, they continue into adult life with the associated negative impact on health, quality of life and health care costs. The correct establishment of the intestinal microbiota (IM) at the beginning of life plays a key role in health, reducing risk of chronic disease. Some factors affecting this process have been studied; however, other like the intrapartum antimicrobial prophylaxis (IAP), in spite of been present on over 30% of total deliveries, have been much less studied. It is already known that at least 11 types of broad-spectrum antibiotics cross the placenta and reach the foetus. Given the increasingly evident relationship between early microbiota, later disease risk and the rising worries regarding antimicrobial resistances, there is an urgent need to assess the potential adverse consequences of IAP in the establishment of the IM and resistome. This project will be the first to study mechanisms orchestrating the impact of IAP on the neonatal IM establishment. The objectives are: identify the alterations induced by IAP in the neonatal IM development; identify the antibiotic resistance genes that the IM carried as consequence of IAP; study the potential role of infant feeding in the modulation of the microbiota after IAP administration and design of specific dietary strategies for minimising the impact of IAP on the IM establishment. Moreover, if the breast-milk exerts a protective role, it would help to strengthen the maternal breast-feeding recommendations. Following this study, doctors will be better able to address the consequences to make knowledge-based decisions about IAP treatment in those situations where it is not extremely mandatory. Besides, the present project will represent a worthy opportunity for the applicant to improve her research competences and career.

Keywords: probiotics,neonates,microbiota,intrapartum antimicrobial prophylaxis,dietary interventions
Precise and Robust Positioning for Automated Road Transports (PRoPART)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Innovation actions
Countries involved: Germany,Germany,Spain,Sweden,Sweden,Hungary
Call: EGNSS Transport applications (H2020-GALILEO-GSA-2017-1, 2017)
Start date: 2017-12-01
End date: 2019-11-30
Duration (months): 24.0
Total project cost (EUR): 3502075.75
EU funding (EUR): 2968128.26
Participants: 9
Project status: CLOSED

The objective of the project ‘PRoPART’ is the development and demonstration of a high availability positioning solution for connected automated driving applications. It aims to develop and enhance an existing RTK (Real Time Kinematic) software solution developed by Flowscape, by exploiting the distinguished features of Galileo signals as well as combining it with other positioning and sensor technologies. Besides the use of vehicle on board sensors, ‘PRoPART’ will also use a low-cost Ultra Wideband (UWB) ranging solution for redundancy and robustness in areas where the coverage of GNSS is poor e.g. in tunnels or in urban canyons. In order to define the correct requirements for the PRoPART combined positioning solution, a cooperative automated vehicle application will be defined and developed. The vehicle application will rely on the high availability positioning solution and use it to couple its ADAS system with V2X and aggregate information received from other connected vehicles and Road Side Units (RSU). As there will be a transition period where a lot of vehicles are neither connected nor automated, solutions having high impact during low penetration are in focus. Therefore ‘PRoPART’ will implement an RSU with high precision positioning and use both UWB as well as a traffic monitoring to supply ranging, object perception and EGNSS RTK correction data via ETSI ITS-G5 to the connected automated vehicle so it can make safe decisions based on robust data. This means that ‘PRoPART’ also will implement perception layer sensor fusion that uses information collected in the LDM (Local Dynamic Map) as well as information from both the on board vehicle sensors and the high availability positioning solution. We will also exploit possibilities to distribute EGNSS RTK correction data from the RSU to the vehicle.

Keywords: egnss,egnss receiver,real time kinematic,galileo e1,galileo e5,connected automated driving,ultra wideband,sensor fusion,etsi its g5,hybrid communication,c its,road side unit
Modelling and assessing the role of air transport in an integrated, intermodal transport system (Modus)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Spain,Spain,Germany,Belgium,France,France,United Kingdom
Call: ATM Role in Intermodal Transport (H2020-SESAR-2019-2, 2019)
Start date: 2020-06-01
End date: 2022-11-30
Duration (months): 30.0
Total project cost (EUR): 1238325.25
EU funding (EUR): 998875.0
Participants: 7
Project status: CLOSED

The Modus project addresses the topic SESAR-ER4-10-2019 "ATM Role in Intermodal Transport". The main objective is the analysis of the performance of the overall transport system by considering the entire door-to-door journey holistically, and assessing the role of air transport within an integrated, intermodal approach. For this purpose, Modus identifies and assesses (future) drivers for passenger demand and supply of mobility in terms of their impact on passenger mode choice. This enables the development of multiple scenarios of future mobility paths, taking into account aspects such as new regulatory contexts meeting new environmental standards, or new transport operators' business models, covering a time horizon of 2030+. An integrated modelling approach which includes the development of data-driven models of air and ground passenger transport in Europe is implemented to assess the impact across these scenario on airside and landside processes and capacities. This provides detailed insight in the impact a complementary intermodal alignment or competition may have on the air transport sector. Using this insight into and modelling results of the future transport system, both quantitative as well as qualitative analyses, including a set of performance and connectivity indicators with specific business and operational targets and constraints, are applied to identify and assess the main gaps and barriers in achieving European (air) mobility goals. Based on these analyses, potential solutions in regard to processes, technologies and changes required to meet high-level European transport objectives are proposed, including, for example, recommending ways how air transport can evolve by efficiently connecting information and services with other transport modes to achieve the e.g. 4 hours door-to-door goal.

Keywords: intermodal,passenger model,gaps and barriers
A sustainable multi-strain, multi-method, multi-product microalgae biorefinery integrating industrial side streams to create high-value products for food, feed and fragrance (MULTI-STR3AM)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Innovation actions
Partnership: BBI (Art-187)
Countries involved: Spain,Spain,Czechia,Netherlands,Netherlands,Netherlands,United States,Netherlands,Portugal,Portugal
Call: Produce components for various materials, including for food and feed, from microalgae (H2020-BBI-JTI-2019, 2019)
Start date: 2020-05-01
End date: 2025-04-30
Duration (months): 60.0
Total project cost (EUR): 9179688.75
EU funding (EUR): 6588732.0
Participants: 11
Project status: SIGNED

MULTI-STR3AM is driven by a critical need to shift to a sustainable means of producing food, feed and raw materials. Microalgae represent a promising solution to address the growing recognition that current agricultural and manufacturing practices are causing irreparable environmental damage. Microalgae, have a vast biosynthetic potential and are a rich source of lipids, protein and high-value compounds such as pigments. Despite these advantages, they are underexploited as a crop. This is due to barriers of scale, which mean that microalgae products struggle to achieve the same economies as conventional products, such as palm oil or soybean. MULTI-STR3AM addresses these challenges by scaling up and lowering costs, providing valuable products for large end users in the food, feed and fragrance sectors. The project reduces costs, increases scale and boosts sustainability, through: i) constant improvement of strains through non-GM methods, to increase their productivity and meet end user needs; ii) design and engineering improvements to cultivation and harvesting technologies to reduce CAPEX and OPEX of biomass production; iii) exploitation of industrial and own side streams during cultivation in a circular economy design; iv) synergistic integration of different technologies in a multi-strain, multi-method, multi-product biorefinery (‘MULTI-biorefinery’); and v) valorisation of every fraction of the microalgal biomass in a zero waste approach. MULTI-STR3AM will demonstrate 7 consumer products, 6 of which are new, including: lipids for edible spreads; protein, carbohydrates and lipids for feed ingredients for poultry, pigs and ruminants; and protein and small organic compounds as building blocks for the fragrance industry. By engaging global actors from the industrial, academic and non-profit sectors, MULTI-STR3AM creates a roadmap for economically viable industrial-scale microalgae cultivation, towards a sustainable future for European bio-based industries.

Keywords: sustainability,food,feed,fragrance,protein,lipids,omega 3,pigments,carotenoids,strain,bio based,value chain,biorefinery,valorisation,fractions,side streams,cascading,cultivation
An Embolic Protection Device for stroke prevention during heart valve replacement. (CAPTIS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 3050000.0
EU funding (EUR): 2135000.0
Participants: 1
Project status: CLOSED

Aortic stenosis (AS) is the most common and most severe heart valve disease, affecting 20 million people worldwide. For patients with severe AS, the most common treatment is valve replacement through Transcatheter Aortic Valve Implantation (TAVI). The procedure is very risky, since embolic debris are released to the blood stream and may reach the brain and other organs, reducing or blocking the blood flow. Strikingly, embolic debris cause new ischemic brain lesions in 70% of patients post TAVI, major disabling strokes in 9%, and kidney dysfunction 12.3% of cases. Embolic Protection Devices (EPDs) are being developed to reduce the risk posed by embolic debris during TAVI. To date, only one EPD has been commercialised for use in TAVI procedure. Unfortunately, the device is poorly effective since it can only provide partial cerebral protection, interferes with the TAVI delivery system, and requires secondary artery access to the TAVI system, thus increasing procedure time and posing the patient at a higher risk of post-operative side effects. Filterlex developed the CAPTIS® system, an innovative intra-aortic Embolic Protection Device (EPD) for deflecting, capturing and removing embolic particles during TAVI procedure. Easily positioned, deployed and retrieved through the same TAVI artery access, this revolutionary EPD provides full-body protection by ensuring the best performance in capturing and safely removing the embolic debris released during TAVI. In this way, CAPTIS strongly reduces the risk of stroke and ischemia to other vital organs. The key objectives of the project are to validate safety and efficacy of the CAPTIS system through a First-In-Human clinical trial and multi-site clinical trial, and to obtain CE mark certification for commercialisation in Europe.

Keywords: embolic protection device,aortic stenosis,heart valve diseases,stroke prevention,tavi,ageing
Economy bY spacE (EYE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain,Italy,Italy,Cyprus,Greece,Poland,Greece,Greece,Poland
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2020, 2020)
Start date: 2021-07-01
End date: 2025-06-30
Duration (months): 48.0
Total project cost (EUR): 1237400.0
EU funding (EUR): 1237400.0
Participants: 12
Project status: SIGNED

Space technology connected with Artificial Intelligence and machine learning techniques is one of the most rapidly developing field of science and also play a key role to control disaster by space like Covid-19 outbreak. While space technologies have been successfully applied to a small number of macroeconomy and heath care related matters over the last decade, there is neither a significant utilization of space elements nor a systematic analysis of needs for space assets in this sector yet. There are a significant number of indirect parameters observable from space that can be correlated to the impact on the economy of natural, health (including epidemic) and man-made disasters. Classical environment parameters (geographical, climatological and hydrogeological) and man induced impact on the environment (pollution, heat) can be combined with economic parameters of human activities impacted by the epidemic including transportation, industry, and commerce. Specific human activities can be directly correlated with the progression of the diseases i.e. increase of heat delivered by crematorium in the affected areas as well as in the dwelling areas due to lock-down restrictions. All these “observed parameters” need to be correlated to macro parameters related to the progress of the epidemic and its impact of the of the infection to the economy at different scales. At medium- and long-term time scale, this methodology enables the near real-time monitoring of macroeconomic parameters during the recovery phase following the end of the emergency outbreak. The project EYE intends to propose a prototype service based on Copernicus data, automatic image processing supported by artificial intelligence integrated with modelling and statistic and geospatial data into an IT platform able to provide econometric and epidemiologic nowcasting and forecasting data.

Keywords: covid 19,macroeconomic indicators,remote sensing,image processing,artificial intelligence
A FRONTrunner approacTransition to a circular & resilient future: deployment of systemic solutions with the support of local clusters and the development of regional community-based innovation schemes (FRONTSH1P)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: Innovation actions
Countries involved: Italy,Italy,Italy,Germany,Italy,Italy,Spain,Spain,Italy,Italy,Italy,Belgium,Poland,Poland,Greece,Switzerland,Poland,Poland,Greece,Greece,Poland,Belgium,Greece,Poland,Poland,Netherlands,Netherlands,Portugal,Portugal
Call: Demonstration of systemic solutions for the territorial deployment of the circular economy (H2020-LC-GD-2020-3, 2020)
Start date: 2021-11-01
End date: 2025-10-31
Duration (months): 48.0
Total project cost (EUR): 19033745.36
EU funding (EUR): 16112118.01
Participants: 38
Project status: SIGNED

FRONTSH1P aims at ensuring green and just transition of the Polish Lodzkie Region towards decarbonization and territorial regeneration through demonstration at TRL7 of highly replicable circular systemic models and FRONTSH1P aims is to create a territorial cluster of circular initiatives to accelerate the transition to a more green, resilient economy, able to provide sustainable responses to the need of the involved regions. The proposed model will be implemented and demonstrated in Lodzkie Region, where key territorial partners, and particularly the Regional Institution, the scientific partner, the representative of civil society and Industry Groups, will play a relevant role in promoting, facilitating, and enabling systemics and circular economy at regional scale. The involvement of those relevant actors will allow the promotion of the circular economy and to reach relevant actors, such as municipalities, companies, consumers, and civil society, which will be engaged in a participatory approach to collect needs and perceived constraints. From this activity, the cluster system will identify and define a circular economy strategy, with clear objectives, measurable targets, and a proper monitoring method. Moreover, the cluster will facilitate collaborations and co-operations among relevant actors for boosting circularity. It will mean to: - Identify already available initiatives and policies at local, regional, national, and international level - Create platforms to explore opportunities and to share information, best practices, and successful examples - Activate a strong communication between universities, businesses, and civil society for the technological transfer - Exchange information and experiences with other Regions and Countries The proposal will foresee activities, such as the definition of regulatory instruments aimed at accelerating the transition to a circular economy creating a Circular Economy Action Plan (CEAP) in which the proposed systemic solution is embedded.

Keywords: circular economy,bio based economy,systemic solutions,circular governance model
Molecular mechanisms of autophagosome formation during selective autophagy (AutoRecon)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Austria
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-03-01
End date: 2021-02-28
Duration (months): 60.0
Total project cost (EUR): 1999640.01
EU funding (EUR): 1999640.0
Participants: 1
Project status: CLOSED

I propose to study how eukaryotic cells generate autophagosomes, organelles bounded by a double membrane. These are formed during autophagy and mediate the degradation of cytoplasmic substances within the lysosomal compartment. Autophagy thereby protects the organism from pathological conditions such as neurodegeneration, cancer and infections. Many core factors required for autophagosome formation have been identified but the order in which they act and their mode of action is still unclear. We will use a combination of biochemical and cell biological approaches to elucidate the choreography and mechanism of these core factors. In particular, we will focus on selective autophagy and determine how the autophagic machinery generates an autophagosome that selectively contains the cargo. To this end we will focus on the cytoplasm-to-vacuole-targeting pathway in S. cerevisiae that mediates the constitutive delivery of the prApe1 enzyme into the vacuole. We will use cargo mimetics or prApe1 complexes in combination with purified autophagy proteins and vesicles to reconstitute the process and so determine which factors are both necessary and sufficient for autophagosome formation, as well as elucidating their mechanism of action. In parallel we will study selective autophagosome formation in human cells. This will reveal common principles and special adaptations. In particular, we will use cell lysates from genome-edited cells in combination with purified autophagy proteins to reconstitute selective autophagosome formation around ubiquitin-positive cargo material. The insights and hypotheses obtained from these reconstituted systems will be validated using cell biological approaches. Taken together, our experiments will allow us to delineate the major steps of autophagosome formation during selective autophagy. Our results will yield detailed insights into how cells form and shape organelles in a de novo manner, which is major question in cell- and developmental biology.

Keywords: autophagy