Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Regulation of the L-arginine – ADMA – Nitric Oxide (NO) Pathway in the Pulmonary Vascular Response to Hypoxia and its Role for Survival of High-Risk COPD Patients (NO PRESSURE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-11-01
End date: 2028-10-31
Duration (months): 60.0
Total project cost (EUR): 2499927.0
EU funding (EUR): 2499927.0
Participants: 1
Project status: SIGNED

NO PRESSURE will address the hypothesis that intermittent hypoxaemia is a major driver of the pulmonary pathophysiology and the systemic co-morbidity that is present at a sub-clinical level already in early disease stages of a significant sub-group of COPD patients with a high risk of rapidly declining lung function and poor prognosis. The project has been conceptualized to achieve ground-breaking scientific insight into the role of intermittent hypoxaemia as a driver of COPD progression and outcome via dysfunction of the L-arginine-ADMA-NO pathway. Its five work packages will span from molecular regulation of the pulmonary L-arginine-ADMA-NO pathway in hypoxia to cellular oxygen sensing and signal transduction mechanisms, via translational studies in genetically modified mouse models and genotyped healthy humans, to clinical proof-of-concept studies of exercise-induced, intermittent hypoxaemia as a diagnostic indicator to identify a subgroup of high-risk COPD patients and the ability to therapeutically intervene by pharmacological modification of the L arginine-ADMA-NO pathway. Combining state-of-the-art molecular biology techniques, specifically designed genetically engineered animal models, and translation of the obtained results into genomically characterized humans who will be exposed to hypoxia, NO PRESSURE will achieve a unique level of depth in our understanding of the molecular pathophysiology of the lung’s response to hypoxia with proven relevance to human biology. Beyond this, NO PRESSURE will take the step towards validation of pathophysiologically proven biomarkers and, thus, molecular mechanisms in the world’s unique long-term prospective cohort for lung disease. In addition, it will deliver unequivocal evidence for clinical utility in two small, but well defined COPD patient cohorts, with one having a focus on prognostic relevance and the other one opening the avenue towards future pharmacotherapeutic intervention to improve prognosis.

Keywords: hypoxic gene expression nitric oxide adma asymmetric dimethylarginine oxygen sensing exertional hypoxaemia biomarker
SYNchrony in Caregiver-Child Interactions across Neurodiversity (SYNCC-IN)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Social Sciences and Humanities
Countries involved: Poland,Italy,Germany,Denmark
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 1417508.62
EU funding (EUR): 1417508.62
Participants: 5
Project status: SIGNED

This project aims to boost sustainable collaboration in a cross-national and cross-disciplinary network, with the University of Warsaw as the widening partner, the University of Heidelberg University of Milano, Copenhagen University, and the University of Trento to facilitate knowledge transfer and exchange of best practices in the research on biobehavioral synchrony. Research exploring how different synchrony measures are related to each other in diverse populations seems highly important, as biobehavioral synchrony is known to support health and psychological well-being. The main goal of the SYNCC-IN project is to strengthen the University of Warsaw's scientific and organizational capacity and to make the University of Warsaw a leading player in biobehavioral synchrony research. The SYNCC-IN project is formed by five universities carefully selected for their complementary expertise in biobehavioral synchrony. It will establish a Virtual Laboratory for Biobehavioral Synchrony led by the University of Warsaw. Leading researchers in the field with complementary expertise and experience in strategic areas will collaborate on this project. The group will develop a protocol to study different levels of synchronization in parallel (behavioral, physiological, neural). Subsequently, this protocol will be applied in a multicenter research project. The transfer of knowledge between partners is vital to this project. Work packages include sustaining changes at the University of Warsaw, conceptual framework building for parent-child synchrony, methodology transfer and integration, joint study, dissemination and outreach, and management and coordination. Twinning funds will help make the Widening Country’s University of Warsaw an important research center within the designated field, strengthening its research and innovation potential within the European Research Area, its international reputation, visibility, and its capacity to compete for research funds as a project leader.

Keywords: interpersonal synchrony,parent child interactions,neurodiversity
Cool-Chips - Cryogenic CMOS chips for quantum, HPC and space industry (COOL-CHIPS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Finland
Call: Emerging quantum technology components (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Cool-Chips project focuses on the commercialization of SemiQon's revolutionary cryogenic CMOS product, designed for the burgeoning quantum, space-electronics hardware and high-performance computing markets. Valued at over 1 billion euros and projected to grow 100 times in the next decade, these markets will benefit greatly from SemiQon's proprietary solution, which offers a 100-fold increase in efficiency over existing technology. This positions SemiQon as a trailblazer in a field dominated by industry giants like INTEL and TSMC. Additionally, SemiQon's agile operational model, which includes in-house manufacturing within a European foundry hosted by an RTO, provides a unique advantage for early market entry and the potential to outpace competitors, establishing it as a groundbreaking European leader in the cryogenic CMOS domain.

Keywords: cryogenic cmos,cryogenic electronics,quantum computing,quantum devices,space electronics
Minimally invasive suturing for vascular bore closure and heart defect repair (NVCD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-08-01
End date: 2027-01-31
Duration (months): 30.0
Total project cost (EUR): 4121068.75
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Cardiovascular diseases (CVDs) remain a major health problem worldwide and a leading cause of mortality, with over annual 18 million deaths. In Europe, CVDs are associated with 4 million deaths and costs of around €210 billion per year. Many surgeries to treat cardiac conditions are shifting to be minimally invasive and this is a trend expected to continue growing due to its multiple advantages over open interventions. However, as newly developed devices for transcatheter procedures become bigger they also require larger vascular access sites. A couple of devices are used in vascular large-bore closure (e.g. ProGlide from Abbott). However, they are associated with still high vascular and bleeding complications (up to 20%, depending on the operator’s skills). Such complications are linked to longer hospitalizations, unnecessary suffering, and greater healthcare costs (€20k per patient), as well as higher morbidity and mortality. To solve this persistent unmet need in the field of cardiovascular surgery, Novelrad has specifically developed the NVCD closure device. It integrates a proprietary and revolutionary micro-suturing technology that mimics the standard surgical technique, effectively delivering a multipoint continuous suture in a minimally invasive manner. The NVCD is easy to use and enables a safer closure of large bores, potentially reducing complication rates to 3%, saving up to 15 min in the procedure, and bringing important cost savings related to same-day discharge and complications’ management. Importantly, with a single NVCD device large and extra-large bore closure of veins and arteries is possible (up to 30Fr). After obtaining a fully functional prototype of the NVCD and advancing in pre-clinical tests, we now aim to perform a first-in-human (FIH) study and complete the clinical trial required to obtain its CE certification as a Class III medical device. This will be crucial to prepare for industrialization and commercial deployment in Europe and globally.

Keywords: cardiovascular diseases,minimally invasive interventions,transcatheter procedures,large bore vascular access closure,cardiovascular micro suturing,vascular closure device,heart defect repair
Alginate Manufacturing by Fermentation (ALGIMAN)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Norway
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Alginate products with high G-content derived from seaweed harvesting are unable to meet current market demands. Global demand is already outstripping supply of food grade alginates, and there is increasing demand resulting from new applications within the food, pharmaceuticals, biotechnology and cosmetics industries. Existing harvesting methods have high production costs, are labour-intensive, and have low extraction yields (especially for low molecular weight G-rich alginates, where 75% of product is wasted). The global alginate market is projected to grow significantly and reach approximately €1 billion by 2028. AlgiPharma has been approached by several major pharmaceutical, biomedical, cosmetic and food clients who are eager for more sustainable and precisely defined alginate products, for their functionality, and in one case to replace components derived from petrochemicals. AlgiPharma has developed a land-based fermentation process but need to scale up this process to serve the global market. This is expected to create significant European competitive advantage in the global production of alginates. AlgiPharma has partnered with a consortium of industrial European partners to establish a unique European manufacturing base to supply these well-defined alginates. AlgiPharma's innovative approach is a sustainable land-based production method, providing a sustainable, scalable and cost-efficient production of highly sought after products. This new method also offers significant environmental and social benefits, providing an environmentally friendly and cost-effective alternative to traditional seaweed harvesting. EIC funding is essential to meet the high initial costs, de-risking the project for future investment, and will enable AlgiPharma to accelerate the scale-up process to promptly meet market demand for large scale production.

Keywords: alginates,fermentation,scale up,manufacturing process
Computational Models for new Patients Stratification Strategies of Neuromuscular Disorders (CoMPaSS-NMD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Italy,Poland,Spain,Germany,France,Finland,Switzerland,United Kingdom
Call: Computational models for new patient stratification strategies (HORIZON-HLTH-2022-TOOL-12-two-stage, 2022)
Start date: 2023-05-01
End date: 2027-04-30
Duration (months): 48.0
Total project cost (EUR): 4956701.25
EU funding (EUR): 4956701.25
Participants: 12
Project status: SIGNED

The CoMPaSS-NMD project creates novel and universal tools for the diagnostic stratification of patients suffering from Hereditary NeuroMuscular Diseases (HNMDs) aiming at personalised treatments. HNMDs often occurs in young people, causing long-term disability and early death; these conditions bring lack of participation, need for permanent assistance and may require long-term institutionalisation. Multidimensional HNMD data - clinical, genetic, histopathological and MRI – will be provided by third-level clinical centers in Italy, France, Germany, Finland and the United Kingdom as part of the European Reference Network for Rare Neurological Diseases. Computational tools for high-dimensional clustering will be applied in an unsupervised learning approach using the internal structure of data to define groups of similar patients. Classification model averaging and integration techniques for federated learning-inspired model building and novel HNMD-specific descriptors of histopathological images will be implemented. The adoption of this multidimensional view has the potential to increment the diagnostic rate of HNMDs by 30% and foster effective actions by European national health systems. As main project outcome, the CoMPaSS-NMD Atlas Platform will be a cost-effective AI-based application providing precise clinical characterization and diagnosis, with data remaining publicly available for anyone in the research and health community to use. The project will deliver Recommendations and Guidelines for stratification-based patient management to offer superior standard-of-care for diagnosis and prognosis and assist in planning clinical trials. It will follow a user-centred, co-design methodology with a strong stakeholder engagement and networking with other project consortia. The project engages partners with clinical, biotechnological, ICT, AI, ethical and legal, communication and exploitation competences: 6 clinical/academic centres, 1 academic, 4 industrial partners.

Keywords: classification,clusterization,deep learning,hereditary neuromuscular disorders,imaging informatics
Performance Optimization of a Hybrid Offshore Wind-Wave Energy Platform (POHOWEP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Canada
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 252724.32
EU funding (EUR): 252724.32
Participants: 2
Project status: SIGNED

Floating Offshore Wind Turbines (FOWTs) have become an emerging trend in wind energy development in the past few years. They offer the possibility of a clean power supply for highly populated countries with access to a deeper offshore area. The main hurdle with FOWTs is that they need to be stabilized since platform motion is undesirable. It makes the rotor aerodynamics and control more complex and reduces aerodynamic efficiency. Additionally, platform motion increases stress on the blades, rotor shaft, yaw bearing, and tower base and it can reduce the component lifespans. FOWT platform motions in pitch, roll and heave must be limited within an acceptable range. Some researchers hypothesized that the platform stabilization may decrease the need for the platform steel mass, active ballast or/and taut mooring lines. Performance Optimization of a Hybrid Offshore Wind-Wave Energy Platform (POHOWEP) is a project which aims to (1) combine a FOWT with Oscillating Water Columns (OWCs) to harness both wave and wind energies and (2) improve the stabilization of the FOWT using the OWCs as an active structural control. The OWCs will be integrated into the floating barge platform which has not been investigated in previous research works. A Machine Learning-based control strategy will be developed to control all the Power Take-Off systems of the OWCs at once. The control of multiple OWCs on a single FOWT requires an adequate strategy that takes into account not only the plant’s state variables but external environmental conditions as well (wind speed, wave speed, wave heights, etc…). The consideration of this external data motivates the use of a Machine Learning (ML) module for the estimation and prediction problems. An ML module will help in the prediction of future wind and wave speeds and estimate the proper reference input value of the designed controllers. Many research works using ML for FOWT’s have been published and proved that ML is a promising solution.

Keywords: automatic control,control design,floating offshore wind turbine,machine learning,oscillating water column,platform stabilization,fore aft and side to side displacements,wind energy,wave energy
High mobilitY Printed nEtwoRks of 2D Semiconductors for advanced electrONICs (HYPERSONIC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,Ireland,Belgium,United Kingdom,Greece
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2024-04-01
End date: 2028-03-31
Duration (months): 48.0
Total project cost (EUR): 3554290.0
EU funding (EUR): 3554290.0
Participants: 8
Project status: SIGNED

Future technological innovations in areas such as the Internet of things and wearable electronics require cheap, easily deformable and reasonably performing printed electronic circuitries. However, current state-of-the-art (SoA) printed electronic devices show mobilities of ~10 cm2/Vs, about ×100 lower than traditional Si-electronics. A promising solution to print devices from 2D semiconducting nanosheets gives relatively low mobilities (~0.1 cm2/Vs) due to the rate-limiting nature of charge transfer (CT) across inter-nanosheet junctions. By minimising the junction resistance RJ, the mobility of printed devices could match that of individual nanosheets, i.e., up to 1000 cm2/Vs for phosphorene, competing with Si. HYPERSONIC is a high-risk, high-gain interdisciplinary project exploiting new chemical and physical approaches to minimise RJ in printed nanosheet networks, leading to ultra-cheap printed devices with a performance ×10–100 beyond the SoA. The chemical approach relies on chemical crosslinking of nanosheets with (semi)conducting molecules to boost inter-nanosheet CT. The physical approach involves synthesising high-aspect-ratio nanosheets, leading to low bending rigidity and increased inter-nanosheet interactions, yielding conformal, large-area junctions of >10e4 nm2 to dramatically reduce RJ. Our radical new technology will use a range of n- or p-type nanosheets to achieve printed networks with mobilities of up to 1000 cm2/Vs. A comprehensive electrical characterisation of all nanosheet networks will allow us to not only identify those with ultra-high mobility but also to fully control the relation between basic physics/chemistry and network mobility. We will demonstrate the utility of our technology by using our best-performing networks as complementary field-effect devices in next- generation, integrated, wearable sensor arrays. Printed digital and analog circuits will read and amplify sensor signals, demonstrating a potential commercialisable application.

Keywords: high performance electronic devices smart circuits flexible and wearable electronics and sensorsnanosheets inter nanosheet junctions layered nanomaterials functionalisation nano mechanics nanochemistry
Inhomogeneity Modelling of Reclaimed Asphalt for Circular Economy in Transport Infrastructure (IMRA4CE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 3
Project status: SIGNED

This project, titled "Inhomogeneity Modelling of Reclaimed Asphalt for Circular Economy in Transport Infrastructure" (IMRA4CE), aims to provide interdisciplinary training for the talented young researcher Dr. Quan Liu. The research will focus on the modelling of inhomogeneity in reclaimed asphalt (RA) with the goal of promoting circular economy principles within transport infrastructure. Key outcomes from IMRA4CE include: (1) elucidation of the mechanisms governing asphalt inhomogeneity; (2) development of innovative fatigue models that consider RA inhomogeneity, and (3) integration of these novel fatigue models into industry practices to optimize design and improve fatigue prediction. IMRA4CE offers comprehensive training to the Fellow, nurturing a promising expert in pavement circular economy with interdisciplinary expertise.This encompasses expertise in pavement mechanics, waste management, physical modelling and computer-aided technology, data modelling and analysis, materials characterisation, and industrial application. In addition to the above, the Fellow will receive interdisciplinary training in project management, intellectual property protection, teaching and supervision, networking, and communication. Upon completion of the training, the Fellow will be equipped to independently lead research projects in Europe.

Keywords: circular economy pavement materials asphalt recycling inhomogeneity fatigue