Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Gender Equality Standards for AHMSSBL institutions throughout Europe (EQUAL4EUROPE)

Framework: Horizon 2020 — Science with and for Society
Programme: Promote gender equality in particular by supporting structural change in the organisation of research institutions and in the content and design of research activities
Action type: Coordination and support actions
Countries involved: Germany,Spain,Belgium,Slovakia,Slovenia,France,Netherlands,Netherlands,Netherlands
Call: Supporting research organisations to implement gender equality plans (H2020-SwafS-2019-1, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 2998132.5
EU funding (EUR): 2998132.5
Participants: 9
Project status: SIGNED

The EQUAL4EUROPE consortium consists of six Research Performing Institutions (RPI) with a clear focus on arts, humanities, medicine, social sciences, business and law (AHMSSBL), and two international accreditation organisations (one as full partner, one as associate partner). Whereas in the past, gender equality was especially recognized as an issue by science, technology, engineering and maths (STEM) RPIs, it is now also recognized by AHMSSBL institutions. However, information for this type of institutions is not yet widely available. Within this project, we will develop free knowledge, tools and best practices for AHMSSBL institutions related to: 1. Removing barriers to the recruitment, retention and career progression of female researchers; 2. Addressing gender imbalances in decision making processes; and, 3. Integrating the gender dimension in research and innovation content. More specifically, the six RPIs will develop and implement tailored Gender Equality Plans (GEPs) in order to realize sustainable cultural and institutional change, an impartial (impact) assessment will be developed and executed, and a network for GE officers from AHMSSBL institutions will be established. Since the consortium aims to maximize the impact, the two accreditation organisations will investigate the possibilities to include the project results into their existing international accreditation frameworks for business schools (with European and global reach). Through their networks, the consortium will be able to reach out to a very large audience. The partners are all complementary to each other, each contributing specific expertise to the project. This expertise will be effectively used during the project which consist of 8 work packages and has a duration of 48 months.

Keywords: gender in arts,humanities,medical,social science,business,network approach,accreditation,standards,gender in research
Inclusive innovation bringing the digitalizing world to the changing care needs and preferences of Europe’s ageing population (mecasa-AI)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2020-01-01
End date: 2020-05-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

EU population today is the oldest it has ever been with 102 million people that are 65 years and older. This number is forecasted to rise to 150 million and account for 30% of the overall EU population by 2050. Since most European seniors wish to stay in their own home when growing old and since nursing homes are relatively more expensive, new care models that prioritize home-care are required. To address this the European Parliament and EU member states are searching for ways to provide high-quality care for the elderly, specifically through informal home-care and technological innovation. Unfortunately, European seniors and caregivers are not getting the support they need. The EU’s unprecedented ageing has created significant and growing need for care. Already today, there is a tremendous skills shortage in caregiving throughout Europe. There are plenty of caregiver recruiting services, but they are ineffective as they are outdated and steeped in conventional paper-based infrastructure. Furthermore, state-of-the-art solutions pair seniors and caregivers without attention to differences in character traits, which too often leads to conflict and subsequently to early termination of caregiving relationships. On top of that, they are expensive, fragmented and difficult to access because they lack online services. mecasa addresses these problems by recruiting personnel via its online platform. Advertising takes place both on- and offline, but actual recruiting is digitized through testing including voice analysis, automated document checks and video interviews. mecasa has developed proprietary matching algorithms, which define matches based on individual character and personality traits. Character traits are measured by standardized psychological testing, subsequently translated into a mathematical logic and eventually enter the mecasa platform. The proposed mecasa-AI project is about further development of the matching engine of the platform.

Keywords: caregivers,seniors,artificial intelligence,psychology
High throughput screening of single-cells using droplet microfluidics (Cells-in-drops)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Lithuania
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-21
End date: 2018-03-20
Duration (months): 24.0
Total project cost (EUR): 130779.6
EU funding (EUR): 130779.6
Participants: 1
Project status: CLOSED

Tackling heterogeneous cell populations at single-cell resolution is becoming increasingly important in different branches of biology and biomedicine. Many useful techniques have been developed to profile and even selectively purify single-cells, however, the demand for techniques with better analytical performance and improved high-throughput capabilities, remains very high. Droplet microfluidics can fulfill this demand by bringing higher throughput, scalability and single molecule resolution that are hard to achieve with conventional technologies. In this project, a droplet microfluidics platform will be developed and applied for ultra-high-throughput single-cell screening and sequencing. The project will be focused on B-cells that produce therapeutic antibodies or biomolecules of industrial interest. Cell compartmentalization into microfluidic droplets together with capture beads and barcoded DNA primers will enable a direct establishment of the linkage between the genotype (genes or mRNA) and phenotype (binding, regulatory or activity of secreted proteins). The proposed work will allow the quantitative high-throughput antibody phenotyping without loosing the original heavy-light chain pairing, a significant advantage over other technologies. Like no other system available to-date this the technological approach outlined in this proposal will provide a unique way to identify the primary sequence of heavy and light IgG genes encoding functional monoclonal antibodies directly from single-cells, without a need to perform gene cloning or cell immortalization. The results of this work are likely to bring a significant impact not only in applied biological sciences but also in biotechnology and biomedicine.
Studying Interfacial Dynamics by Interferometric Scattering (INTFACDYN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

We propose to apply a cutting-edge optical microscopy based on interferometric scattering microscopy (iSCAT) to directly study the dynamics of the fundamental system of nanoparticles at fluid interfaces. Nanoparticles at interfaces are a central research topic in colloidal science. They have various technological applications, related to, for example, emulsification, optical devices, and chemical catalysis. In addition, nanoparticles at interfaces make an ideal experimental model system for investigating topics in condensed matter physics, such as the dynamics of partially confined fluids and the phase behavior of 2D fluids. While many experimental studies have characterized the self-assembly, structure, and motion of such particles, important questions relating to adsorption/desorption dynamics and inertial effects, remain unanswered due to technical limitations of temporal and spatial resolution. iSCAT offers exclusive accessibility to answer these questions, through unprecedented capabilities of nanoparticle tracking in three dimensions with simultaneous nanometre spatial and microsecond temporal precision. Specifically, we aim at achieving two objectives for the first time; (i) observing and quantifying inertial effects at fluid-fluid interfaces, and (ii) characterizing the three-dimensional interfacial behavior of nanoparticles at interfaces. Overall, these objectives aim at expanding and generalising interfacial microrheology to much shorter time-scales, as well as to provide critical insight to the mechanisms underlying particle stability and self-assembly at interfaces.

Keywords: nanoparticles at fluid interfaces,interfacial dynamics,inertial effect at fluid interfaces,adsorption,desorption dynamic at interfaces,pickering emulsions,interferometric scattering microscopy
The implementation of the EU employment policies in Germany, Italy and Denmark (EUP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-06-29
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Unemployment is one of the major challenges that the world economy is facing at present. The European Union (EU) is trying to cope with this problem by promoting the flexicurity strategy (Europe 2020: COM(2010) 2020 final). This strategy aims to conciliate the flexibility requested by companies and the social and employment security needed by workers (COM(2007) 359 final). One of its main aspects concerns the relevant role recognized to active and passive labour market policies (active and passive LMPs). At the same time, the flexicurity concept is vague and ambiguous: this aspect brings difficulties in its implementation, and can have negative implications on the level of protection of unemployed people. The research project aims to analyse the legal implementation/adaptation (i./a.) of the flexicurity strategy – with regard to active and passive LMPs – in three member states: Germany, Italy and Denmark, that are representative of three different kinds of social security systems in EU, (Continental, Mediterranean and Nordic systems). The legal i./a. will be analysed throughout an innovative inter/multidisciplinary approach focused on widen the labour law perspective throughout an applicative analysis (labour economics) and an analysis of the constitutional rights involved (constitutional law and political philosophy). By highlighting different processes of legal i./a. of the active and passive LMPs in the considered member States, the research will contribute to increase the effectiveness of the EU employment policies in order to achieve adequate level of social security protection and activation possibilities for the EU citizens. Thus, the project aims to formulate Employment Policy Suggestions, which can be deduced from the empirical analysis outcomes, considering also integrative approaches and strategies to the flexicurity.

Keywords: employment policies,unemployment,active labour market policies,passive labour market policies,unemployment benefits,social security system
Solar-to-Chemical Energy Conversion with Advanced Nitride Semiconductors (SECANS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-07-01
End date: 2025-06-30
Duration (months): 60.0
Total project cost (EUR): 1933750.0
EU funding (EUR): 1933750.0
Participants: 1
Project status: SIGNED

As photovoltaic technologies gain prominence, an outstanding challenge is the development of systems that can robustly store solar energy with high density. Within this context, the capture of sunlight and its direct conversion to chemical fuels in artificial photosystems provides a promising route for sustainably meeting future energy demands. However, a central challenge is the lack of systems that can efficiently direct light excitations towards desired chemical products with high efficiency and stability under harsh reaction conditions. In recent years, advances in using thin films to protect chemically sensitive light absorbers have relaxed the requirement for intrinsically stable semiconductors and motivate an entirely new perspective for rational design of materials and interfaces. Within this context, SECANS aims to create the scientific basis for solar-to-chemical devices that achieve unprecedented combinations of efficiency and stability, enabled by targeted exploration and rational optimization of an underexplored class of materials – transition metal nitride semiconductors. The electronic structures of these materials can enable a favourable balance between large charge carrier mobility and high defect tolerance. However, due to the high stability of molecular nitrogen, the expansive range of possible nitrides is largely unexplored and their basic properties poorly understood. SECANS overcomes these challenges through an interdisciplinary approach that couples non-equilibrium semiconductor deposition and newly developed interface engineering methods, supported by advanced operando spectroscopies, to enable high efficiency light harvesting systems with self-healing interfaces. This project will develop novel nitride semiconductors optimized for solar-to-chemical energy conversion, elucidate the roles of defects and disorder on competitive kinetics within photochemical reaction cycles, and provide new insights into the science of photochemical stability.

Keywords: photoelectrochemistry,artificial photosynthesis,semiconductors,interface engineering,in situ and operando spectroscopy,metastable materials,non equilibrium synthesis of materials,disorder engineering,electrocatalysis
METAdiag: Diagnose to Cure (METAdiag)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: France
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

As all living organisms, our cells need to feed on a balanced diet to stay healthy and correctly function. To do that, cells adapt their nutrient consumption according to their energetic needs. If the uptake mechanism is impaired, it impacts cell metabolism. Both starving cells & overfeeding cells are a hallmark for the onset and progress of serious diseases like diabetes, cancer or inborn errors of metabolism, which can all be seen as metabolic diseases. These are debilitating conditions that need lifelong treatments, entail poorer life quality and incur a major economic burden. Subjects appear initially healthy and symptoms are often overlooked, but by the time of diagnosis, damage can no longer be reverted. Conversely, early detection could prevent most of the damages by starting specific therapies. However, despite the fact that all metabolic diseases have abnormal cell energetics, there are no tests for cell metabolism in clinical practice. In response, we at METAFORA aim to bring to market METAdiag, the first diagnostic platform able to assess and monitor the metabolic status of our cells. This unique and non-invasive diagnostic system is able to detect abnormal cell energetics by quantifying the levels of nutrient transporters at the cell surface. After proving the reliability and accuracy of our platform at a small scale, we now aim to take a step further towards the market. Thus, in Phase 1 we aim to conduct a Feasibility Study that will help us to assess and achieve the significant milestones influencing the project from the technical, commercial and financial perspectives. Based on proprietary technology and on a strong collaboration network, METAdiag will be uniquely positioned to detect metabolic impairments, allowing clinicians to achieve an earlier diagnosis and patients to receive better management and prognosis. In turn, METAdiag will boost the growth of our company, expecting to generate €42 million in revenues and to hire 22 new people in 5 years.

Keywords: metabolic conditions,early diagnosis,abnormal cellular energetics,diagnostics platfom,serious human diseases,errors of metabolism,debilitating diseases
Interactions between reversible and irreversible Operator Algebras. (IRIOA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-05
End date: 2021-12-23
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

We propose a systematic study of interactions between self-adjoint (reversible) and non-self-adjoint (irreversible) operator algebras. We shall import Arveson's C*-envelope and Hamana's non-commutative Furstenberg boundary to the group-graded contexts, and use them to obtain new structural, dilation and classification results for various operator algebras. The goals of this proposal are as follows: Goal A is to advance the structure theory of semigroup Nica C*-algebras and Crisp-Laca boundary quotient C*-algebras, with applications in semigroup theory. This will be achieved by adapting Hamana boundary techniques used in a recent breakthrough characterization of simplicity of reduced group C*-algebras due to Kennedy and Kalantar. Goal B is to extend work of the ER with Katsoulis to the non-abelian group-graded context and determine if the C*-envelope of the irreversible tensor algebras in Fowler's context is the Cuntz-Nica-Pimsner algebra. Applications include new Laca-type dilation results, Hao-Ng isomorphisms and non-commutative Takai-type duality. Goal C is to obtain new classification results for reversible and irreversible operator algebras by a two-way flow between the theories. This will be done by uncovering the hierarchy between invariants of C*-algebras with additional structure and of non-self-adjoint operator algebras, leading to insight on an open problem of Davidson and Katsoulis in dynamics. The anticipated results in the proposal are original and innovative, and will have an impact on the field well after the end of the fellowship. Each project is chosen to optimize the transfer of knowledge between the ER and the supervisor as well as the group in operator algebras at Copenhagen University. Considering the ambitious research program, supervision, outreach, as well as other activities suggested, the MSC IF will have a lasting influence on the ER's career and will allow him to obtain a permanent academic position after the completion of the fellowship.

Keywords: non self adjoint,c envelope,dilation,boundary quotients,c algebras,tensor algebras,semigroups algebras,toeplitz nica,cuntz nica,hao ng isomorphism,c simplicity,classification
Cancer treatment during pregnancy: from fetal safety to maternal efficacy (CRADLE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Belgium,Netherlands
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-10-01
End date: 2021-03-31
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 1709375.0
Participants: 2
Project status: CLOSED

The evolution in drug regulation of the last 50 years has left pregnant women and their fetuses orphaned. This is particularly problematic for cancer during pregnancy, which raises a difficult and conflicting medical ethical decision process and which has recently become increasingly frequent. In 2012 we published the first prospective study indicating that antenatal exposure to cancer treatment can overall be considered safe. Building on this proof of concept, the current proposal wants to take a groundbreaking step towards developing a standard of care for cancer during pregnancy by addressing –in an integrated fashion- the challenges at the level of the fetus, the mother and the fetomaternal barrier. At the core of this proposal lies an international registry of pregnant women with cancer, along with a registry of their children, and biobanks of maternal, placental, cord blood and tumoral tissues. Research track ‘child’ aims to deliver robust evidence of fetal safety. Research track ‘mother’ aims to address the emerging concerns in the oncological management of the mother, and specifically, the possible distinct biology of pregnancy-associated breast cancer, the most frequent cancer type in pregnancy. The research approach includes large-scale clinical follow-up studies along with laboratory studies on patient biomaterials, including pharmacological investigations and RNA-sequencing studies. Complementary to these studies is research track ‘placenta’ in which cutting-edge models of human placental research are used to address the poorly understood physiological basis of the placental barrier function in this specific situation. This ambitious program will rely on a multidisciplinary team of experts. Not only may the scientific deliverables of this proposal constitute a major step forward to the well-being of both mother and fetus in a pregnancy complicated by cancer, the methodological approach may also provide critical impetus to further research in this field.

Keywords: cancer,chemotherapy,pregnancy,pediatric