Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Bioactive Tissue Sealant for Enhanced Wound Repair (BioTisSeal)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-06-01
End date: 2023-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Wound management is a routine part of medical practices worldwide, and delays in healing cause a significant clinical and economic burden. Current tissue sealant formulations that are used for wound care pose various limitations, including inability for filling in larger defects and release of toxic by-products (especially from synthetic polymers). Additionally, most of the commercial sealants provide no bioactive properties, or at best rely on bulk GF loading for inducing cell infiltration or tissue regeneration. The development of a tunable, bioactive hydrogel based tissue sealants thus provides an attractive opportunity as cell-instructive substrates for enhanced wound healing. BioTisSeal aims to develop the technology for fabricating “off-the shelf” bioactive tissue sealants that can not only help in wound closure (or reduce blood loss), but also stimulate better healing. BioTisSeal will combine the tunable elasticity and adhesive strength of gelatin methacryloyl (GelMA) pre-polymers with angiogenic growth factor (GF) specific aptamers that are capable of sequestering and concentrating GFs that are already present in the tissue fluid at the wound site. By coupling this to the controlled release behavior of aptamers, a spatiotemporal control of GF bioavailability is achieved for enhanced wound repair. BioTisSeal will not only develop the technology to make this possible, but will also take vital steps to bring this technology to the market. By securing the IP, and analyzing the market connected to BioTisSeal technology, a fruitful basis for translation will be formed. The inclusion of both a leading wound care company and a clinician in the advisory board, will further ensure that BioTisSeal is optimally geared towards clinical translation.
Multi-functional hydrogels for promoting bone fracture healing through local induced release of pharmaceutical agents and gradual matrix replacement by the regenerating bone (HYDROHEAL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Innovation actions
Countries involved: Spain,United Kingdom,Germany,Italy,Cyprus,Ireland,Portugal
Call: Advanced biomaterials for the Health Care (IA) (HORIZON-CL4-2024-RESILIENCE-01-TWO-STAGE, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 7206962.03
EU funding (EUR): 6453740.88
Participants: 13
Project status: SIGNED

Bone atrophy and fractures, resulting from trauma, infections, osteoporosis, or cancer, are global health concerns. Standard care with cement and bone grafts has limitations. Synthetic polymers like polymethyl methacrylate risk leakage, spinal issues, and poor healing. Donor shortages for allogenic bone grafting and invasive procedures pose risks such as rejection and viral transmission. HYDROHEAL innovates with hydrogel formulations to address bone strength challenges by treating vertebral and alveolar fractures. HYDROHEAL aims to develop safe, sustainable scaling, and cost-effective formulations using renewable biomaterials for targeted drug delivery, aligning closely with the EU Circular Economy Action Plan and Chemicals Strategy for Sustainability. It is ready to introduce a new era in fracture therapy. The proposed self-solidifying hydrogels release active pharmaceutical ingredients locally upon external stimulation, potentially improving treatment efficacy, preventing infections, and speeding up fracture healing. The objectives of the project are: 1. Develop novel injectable hydrogel formulations combining natural substance derivates to enhance healing, inhibit bacterial growth, and monitor therapy progress in vivo. 2. Simultaneously manufacture carriers as micro- and nano-particles, surface-functionalized to incorporate pharmaceutical agents, releaseable upon external stimuli for tailored drug release. 3. Validate safe and optimized hydrogel formulations for treating vertebral and alveolar bone fractures through in vitro and in vivo tests. 4. Demonstrate scalable and sustainable biomaterial manufacturing through safe design methods, machine learning, and predictive life cycle assessment. 5. Develop machine learning and hybrid digital modeling methods, combining adaptive design of experiments and physics-based modeling with advanced characterization techniques.

Keywords: biomedical engineering,layer by layer assembly,composite hydrogel,bone fractures,smart carriers
Control of myotube growth for the generation of synthetic muscular micro-actuators (MYOFORCE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-12-31
Duration (months): 28.0
Total project cost (EUR): 188037.27
EU funding (EUR): 188037.27
Participants: 2
Project status: SIGNED

Millions of years of natural evolution have refined cellular tissues into exceptionally sophisticated materials. Not only they present the widest spectrum of mechanical properties, but they also self-organize, generate forces at different scales, react to external stimuli, and self-heal. Exploiting the unique features of tissues to build biohybrid actuators is thus the new paradigm in soft robotics. Muscular (myo-) tissues, composed of myotubes, are highly contractile and have become the main choice for the design of biohybrid actuators, typically millimetric hydrogel objects embedding muscle cells. Importantly, due to a combination of factors, including a lack of control on myotube growth, poor integration of the myotubes with their environment, or slow nutrient perfusion, artificial muscular tissues have so far displayed significantly low efficiencies compared with natural muscle. Furthermore, current biohybrid actuators hinder both the characterization of myotubes’ architecture and the mapping of forces at the myotube scale. To overcome these limitations, we propose a new approach to prepare biohybrid actuators based on the control of myotube growth at the microscale. First, we propose a platform to grow myotubes with controlled size and shape, and to characterize their contractile behavior. By using this platform, I will be able to investigate the interplay between myotube architecture and force generation. Second, we propose a set of fine-tuned artificial scaffolds, which will guide myotube growth and self-integration, leading to active composites able to generate specific mechanical tasks. Finally, to tame the self-contractility of the active composites, optogenetically-modified myotubes will be incorporated, allowing external actuation with light. This proposal presents a novel experimental toolbox for controlling the shape of myotubes and mapping their forces at the micron scale, both key for designing efficient muscular micro-actuators.

Keywords: mechanobiology,biophysics,soft robotics,biohybrid devices,myotubes,traction force microscopy,optogenetics,micropatterning,microfabrication
Demonstrating innovative pathways addressing water and soil pollution in the Mediterranean Agro-Hydro-System (Path4Med)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Greece,Norway,Denmark,Poland,Italy,Portugal,Germany,Netherlands,Spain,Czechia,Ukraine,Türkiye,Cyprus,Albania,France,Switzerland
Call: Mission Ocean and Waters and Mission A Soil Deal for Europe – Joint demonstration of approaches and solutions to address nutrient pollution in the landscape-river-sea system in the Mediterranean sea basin (HORIZON-MISS-2023-OCEAN-SOIL-01, 2023)
Start date: 2024-07-01
End date: 2028-06-30
Duration (months): 48.0
Total project cost (EUR): 8483712.5
EU funding (EUR): 8059322.75
Participants: 26
Project status: SIGNED

Path4Med is a multi-participatory and multidisciplinary project that will pave clear pathways towards zero water and soil pollution in the agro-hydro-system of the Mediterranean sea basin and other European seas through an innovative triple bottom line approach achieving economic, social, and environmental sustainability to ensure human well-being and ecosystems functioning. Path4Med will advance and consolidate agricultural management technologies and solutions within an inclusive and open participatory environment, it will evolve and mainstream novel monitoring technologies and integrated solutions, it will assess the technical feasibility and socioeconomic viability of cascades of solutions through an integrated modelling framework, it will quantify the effectiveness and the net impact of these solutions, and ultimately it will empower Citizens to take action against pollution of soils, waters and the ocean, through clear measurable evidences, increased awareness, and water literacy. Path4Med pathways will be applied and demonstrated in large scale, integrated, Demonstration Sites established in representative Mediterranean areas, in areas representing other European seas and in associated regions. A digital platform and other relevant digital tools will be established to facilitate Path4Med actions, information and knowhow communication, and to support data exchange and data feeding to international Observatories and Knowledge Systems.

Keywords: soil and water pollution,excess nutrients,monitoring technologies,earth observation,biobased indicators,agricultural management technologies,common agricultural policy
Novel biobased formulations for CIRCULAR Construction materials (CIRCULAR-C)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Research and Innovation actions
Countries involved: Germany,France,Finland,Greece,Türkiye,Belgium,Netherlands
Call: Circular design of bio-based processes and products (HORIZON-CL6-2024-CIRCBIO-02, 2024)
Start date: 2025-06-01
End date: 2029-05-31
Duration (months): 48.0
Total project cost (EUR): 3999998.25
EU funding (EUR): 3999998.25
Participants: 10
Project status: SIGNED

CIRCULAR-C is a demand-driven research and innovation action aiming to transform the biobased chemical sector for construction applications by developing a new generation of circular, sustainable, and biobased adhesives, coatings, and functionalised fibres at TRL 5. These new formulations for wood panel construction (used in flooring, furniture, and insulation) featuring reversible chemical bonds and Digital Product Passports enhance recycling and reduce environmental impact. Thus, CIRCULAR-C will validate and optimise a process using mixed sustainable biomass residues as feedstock to produce high-strength functionalised cellulosic materials and circular adhesives and coatings with high bio-based content, fire retardancy and reversibility. Industrial partners will test these formulations in construction panels and validate them against industry requirements. In addition, the novel disassembly, recycling, and remanufacturing of the panels will be validated, and comprehensive digital product passports (DPPs) prepared to track the lifecycle and sustainability metrics of our products. The safety, circularity, and sustainability of processes and products will be assessed during all development stages, and we will ensure that the project outcomes are widely disseminated, and their economic feasibility validated. Through these efforts, CIRCULAR-C will increase the capacity of biobased sectors by maximizing residue valorisation and material recycling, as well as minimizing environmental and climate impact. Our long-term impact by 2038, calls to operate a fully scaled CIRCULAR-C plant with an annual output of 10.8 kt of adhesives, 12 kt of coatings, 50 kt of functionalised fibres and 15.3 kt non-PU foams, which could be potentially used in 75,000 residencies. This venture is expected to generate €114 million in revenue and sustain 381 full-time jobs while cutting the use of hazardous chemicals by over 75% and reducing 80 -100% GHG emissions to achieve climate neutrality.

Keywords: biobased adhesives,biobased coatings,bio based materials,circular construction panels,biomass residues,recycling,digital product passports dpps,reversible chemistry,fractionation process
CIVIL ENGINEERING AND GEOMATICS INNOVATIVE RESEARCH ON HERITAGE (ENGINEER)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Cyprus,Italy,United Kingdom,Portugal
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 1271892.5
EU funding (EUR): 1271892.5
Participants: 5
Project status: SIGNED

ENGINEER proposal aims to enhance the Department of Civil Engineering and Geomatics of the Cyprus University of Technology (CUT) research and innovation potentials through coordination and support actions provided by the Twinning call. Build upon its unique character, as the single University Department of the country, where civil and geomatics engineers come together, the Twinning project will fulfil and extend inter-departmental research activities in cultural heritage (CH). Smart Specialisation Strategy of Cyprus (S3CY), was designed to pave the wave for future sustainable development of the country, capitalising on its unique characteristics and research ecosystem. S3CY’s final report puts CH at the heart of the country's future development as a horizontal pillar, whereas other disciplines such as tourism - the main economic revenue stream of the country- and ICT can interact. The proposal visions to fill research gaps, push, and extend knowledge into new innovative fields dealing with the monitoring, digitisation, visualization and preservation of CH, assisting towards their protection, promotion and safeguarding. For this vision, CUT has aligned forces with three leading institutions of Europe, namely the Polytechnic University of Milan (POLIMI), the University College of London (UCL), and the University of Aveiro (UAVEIRO). The leading teams will work closely with the local team through targeting training research activities, mobility actions, networking and in-situ pilot applications. At the same time, the leading institutions will advance research management, administrative skills and promote industrial and knowledge transfer, thus reforming the Department's R&I system. The participation of the Eratosthenes Centre of Excellence (ECoE) will multiply the potential impact of the project, creating strong links with partners of the quadruple helix of the smart specialization, and will support commercialization and marketed aspects.

Keywords: geomatics,civil engineering,cultrual heritage,digitization,documentation,structural engineering,earthquake,monuments
MOLecular Materials for Passivation in large Area Perovskite Solar modules (MOLMAPS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 191760.0
EU funding (EUR): 191760.0
Participants: 1
Project status: SIGNED

Perovskite solar cells (PSCs) have emerged as highly promising next-generation photovoltaic technologies, distinguished by their exceptional combination of superior photovoltaic performance and cost-effective manufacturing. Despite their remarkable potential, the commercialization of large-area PSCs remains a formidable challenge, presenting a critical obstacle in the field of perovskite photovoltaics. The core objective of this project is to spearhead the development of efficient and durable perovskite solar modules (PSMs) that are pertinent to industrially relevant scale. We aim to demonstrate power conversion efficiencies of ≥23% and ≥20% on 100 cm2 and 800 cm2 modules, respectively. To achieve this ambitious goal, we will adopt an interdisciplinary approach, to devise a novel strategy for absorber and interface engineering on a large scale. This breakthrough method will enable uniform crystal growth on a large scale, resulting in perovskite films with high homogeneity and creating interfaces with nanoscale uniformity and robust interfacial adhesion in large-scale modules. The stability of these modules will undergo rigorous testing in accordance with IEC and ISOS protocols. Simultaneously, alongside the device/module fabrication and stability testing phases, we will embark on fundamental investigations utilizing advanced techniques to gain a comprehensive understanding of the material's operational mechanisms within the modules. This project capitalizes on the host lab's extensive proficiency in perovskite module fabrication, which is complemented by the applicant’s strong background in material design and synthesis. This project will not only significantly enrich the fellow's skill set but also instill invaluable leadership qualities and management skills poised to shape their future career.

Keywords: perovskite photovoltaics scalable perovskite module fabrication interface passivation additive engineering stable perovskites
Enabling stakeholder-centric zero emission e-commerce delivery and return practices through transparent and collaborative supply chains (GreenTurn)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Countries involved: Poland,Netherlands,Sweden,Belgium,Greece,Spain,Austria
Call: Zero-emission e-commerce and freight delivery and return choices by retailers, consumers and local authorities (HORIZON-CL5-2023-D6-01, 2023)
Start date: 2024-08-01
End date: 2027-07-31
Duration (months): 36.0
Total project cost (EUR): 2999067.5
EU funding (EUR): 2999067.5
Participants: 14
Project status: SIGNED

While Europeans can track and understand their personal transport emissions, they have little to no information regarding the impact of their online shopping deliveries and returns. This is due to a mix of challenges, including the complexity of calculating emissions across the e-commerce supply chain, and the limited regulatory levers public authorities have to influence greener practices. To overcome these challenges, GreenTurn brings together a diverse range of e-commerce stakeholders to co-create zero-emission logistics solutions, provide sound and transparent information on e-commerce footprints, and enable more sustainable delivery and return choices. The consortium comprises 14 partners from 7 different countries, and is further complemented by its Stakeholder Advisory Board, activated during key project moments. GreenTurn uses design thinking approaches to develop solutions which bridge between behavioural interventions (including incentives, nudges and gamification) and delivery and return options (such as time windows, in-store pick-ups and returnable packaging, among others). To test solutions, GreenTurn implements 5 complementary pilots involving 1 LSP, 1 marketplace provider and 1 retailer - as partners, and >8 LSPs, >3 marketplaces, >7 retailers - as stakeholders. Through the involvement of significant and diverse companies, the project has potential to reach and raise awareness among >30M e-commerce consumers from 5 countries: Poland, Spain, France, Greece and Austria. Advanced logistics systems allow the five pilots to offer, on average, 82% of delivery and return options as zero-emission. Besides, the GreenTurn pilots will touch upon social sustainability aspects too, for both customers (e.g., physical and digital accessibility), and e-commerce logistics employees (e.g., work conditions, market reintegration, etc.) Together with its public authorities, GreenTurn will translate results into policies that can secure uptake and long-term impact.

Keywords: stakeholder centric,green logistics,sustainable e commerce,collaborative supply chains,transparent footprints
Multiscale modelling for wind farm design, performance assessment and loading (MERIDIONAL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Netherlands,Denmark,Germany,Italy,United States,Belgium
Call: Physics and aerodynamics of atmospheric flow of wind for power production (HORIZON-CL5-2021-D3-03, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 5996868.75
EU funding (EUR): 5996868.5
Participants: 12
Project status: SIGNED

The wind industry is developing wind turbines and airborne wind energy devices which span altitudes well above the well-studied surface layer. A full understanding of the unsteady inflow conditions which drive loads and performance at these altitudes is lacking. MERIDIONAL will provide a comprehensively validated tool chain based on an open-source platform which will draw on an integrated knowledge and data hub to allow the efficient and accurate assessment of the performance and loads experienced by onshore, offshore, and airborne wind energy systems. This tool chain can be used for component, device and plant level planning and operation. It will consist of models which can capture the unsteady time-resolved inflow structures which drive performance and loads within the wind plant, incorporating inter and intra farm turbine interactions. Inflow conditions will be analysed and modelled beyond the surface layer to capture the conditions within and above the atmospheric boundary layer. This is critical to a full understanding of the loads and performance of wind farms and airborne wind energy devices. Model validation will be underpinned by a range of high quality and unique datasets drawing on high-fidelity simulations, and kite-borne, lidar, drone and mast measurements from field test campaigns in complex terrain, offshore and airborne. The strength of the tool chain results from developing different models for different situations, using higher order approaches (e.g., meso and microscale LES) when required and lower order models (physics or data-driven) where these are sufficient to accurately predict loads and performance. The knowledge and data hub will allow users of the tool chain to draw on a wide range of existing and project-generated measurement and simulation data to allow site specific analysis to be carried out at any location. MERIDIONAL allows stakeholders to increase wind plant efficiency and reduce material costs through less conservative design.

Keywords: modelling,measurement,cfd,les,loads,database,turbulence,wakes,resource,awes,wind farms,wind turbines,energy yield,drones,kites,ai