Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
OPtimization and integration of Dirac semimeTal-bIsmuth in spin-to-charge conversiON devices (OPTION)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-05-01
End date: 2028-04-30
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

The rise of electronic devices challenges sustainability, as nanometer-sized transistors are nearing their physical limits in addition to severe energy costs. New technologies are essential to meet the growing demands of consumer electronics. Spintronics is considered to be a leading solution to improve scalability and power efficiency, and shows potential not only in memory technologies but also in logic operations, supported by recent advances in spin-based computation. Among them, one promising prototype is the magnetoelectric spin-orbit device by integrating non-volatile magnetic switching via magnetoelectric coupling with spin injection and spin-to-charge conversion. The main goal of OPTION is to realize such a functional device by exploring novel Dirac semimetals with large spin-to-charge conversion efficiency and high resistivity to improve the output voltage signal. To achieve this result, we will sputter and optimize high-quality Dirac semimetals to maximize spin-orbit coupling strength as well as resistivity; insert a tunnel barrier between high resistive Dirac semimetals and metallic ferromagnetic layers to ensure a large spin injection efficiency; verify the repeatable and stable voltage-driven magnetic switching of the multiferroic materials, and finally integrate different modules into a full structure. Within OPTION, we will employ kinds of film deposition facilities, structural and physical properties characterizations and advanced nanofabrication techniques for which the host institution is expert, such as high-vacuum sputtering and e-beam lithography. The ultimate scientific ambition of OPTION is to achieve power-efficient functional logic devices, thereby benchmarking novel sustainable computing paradigms and bridging the fundamental science and technological applications. Moreover, OPTION will provide high-quality, interdisciplinary research and transversal skills to an aspiring young researcher for the development of her career.

Keywords: spin to charge conversion,dirac semimetals,magnetoelectric spin orbit logic device,beyond cmos technology
Reversible Heterolytic Mechanophores for Dynamic Bulk Materials (ReHuse)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-08-01
End date: 2028-07-31
Duration (months): 60.0
Total project cost (EUR): 1498401.0
EU funding (EUR): 1498401.0
Participants: 1
Project status: SIGNED

Stimuli-responsive polymers adapt their properties in response to external cues. Engineering such “smart” behaviour in artificial systems by molecular design is an exciting fundamental challenge that can lead to technological breakthroughs. Most stimuli-responsive polymers rely on heat and light to trigger changes in materials properties in a predictable fashion. However, limitations intrinsic to these stimuli highlight the necessity of alternative strategies. Naturally evolved systems widely exploit mechanical stimulation to regulate their functions, but recreating such concept in artificial materials has proven extremely challenging thus far. ReHuse proposes a radically new approach that focuses on the application of mechanical force to induce changes in bulk materials properties isothermally and reversibly. The research project aims at pushing the frontiers of covalent mechanochemistry through the development of reversible heterolytic mechanophores –molecular platforms that dynamically generate and recombine two oppositely charged (macro)molecular fragments upon mechanical stimulation. These new motifs will enable dynamic chemistries involving organic ionic species in solid-state systems in two different types of advanced bulk materials. Combining reversible mechanochemistry and dynamic covalent chemistry will lead to dynamic covalent polymers displaying selective mechanoresponsiveness. This concept will be leveraged to create recyclable materials. The reversible generation of charges from the heterolytic scission will enable to modulate hydrophilicity/hydrophobicity dynamically. Such principles will be explored to set the groundwork for mechano-responsive atmospheric water harvesters. This interdisciplinary research project will advance our understanding of mechanochemistry and, more importantly, will usher new avenues for its productive and repeatable use in adaptive materials.

Keywords: mechanochemistry,stimuli responsive polymers,circular chemistry
Secure Hardware and Software for AI systems (SHASAI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Increased Cybersecurity
Action type: Innovation actions
Countries involved: Spain,Italy,Netherlands,Germany,Türkiye
Call: Approaches and tools for security in software and hardware development and assessment (HORIZON-CL3-2024-CS-01, 2024)
Start date: 2025-11-01
End date: 2029-04-30
Duration (months): 42.0
Total project cost (EUR): 7401272.67
EU funding (EUR): 5999514.38
Participants: 16
Project status: SIGNED

SHASAI targets the HW/SW security and AI-based high risk systems intersection, aiming to enhance the security, resilience, automated testing, and continuous assessment of AI systems. The rising interest in these systems makes them attractive targets for threat actors due to their complexity and valuable data. Ensuring the security of AI systems involves safeguarding AI models, datasets, dependencies, and securing the underlying HW/SW infrastructure. SHASAI takes a holistic approach of AI system security throughout their lifecycle stages. At requirement definition, SHASAI provides an enhanced risk assessment methodology for secure and safe AI. At design, SHASAI will propose secure and safe design patterns at SW and HW level to achieve trustworthy AI systems. During implementation, SHASAI provides tooling for a secure supply chain of the system by analyzing vulnerabilities in SW / HW dependencies, detecting poisoned data and backdoors in pretrained models, scanning for software vulnerabilities, hardening hardware platforms, and safeguarding intellectual property. At evaluation, SHASAI offers a virtual testing platform with automated attack and defense test suites to assess security against AI and infrastructure-specific threats. In operation, AI-enhanced security services continuously monitor the system, detect anomalies, and mitigate attacks using AI firewalls and attestation methods, ensuring availability and integrity. The feasibility of SHASAI methods and tools will be demonstrated in 3 real scenarios: 1. Agrifood industry: Cutting machines. 2. Health: Eye-tracking systems in augmentative and alternative communication. 3. Automotive: Tele-operated last mile delivery vehicle. Their heterogeneity and complementarity maximize the transferability of solutions. SHASAI will contribute to scientific, techno-economic, and societal impacts as it aligns with the CRA, EU AI Act, NIS2 and CSA, sharing and commercializing methods and tools to ensure trustworthy AI components.
DNA modules as communicators in tumor immunomodulation (DNAPC4ImunoMol)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: CLOSED

Our goal is to develop all-DNA structures (protocells) that can act as modulators of the immune system and, in particular, of signaling processes in oncology. Molecular DNA switches that interact with cells via aptamers have been developed and used for drug delivery, cell imaging, and potential therapies. However, there are several advantages of incorporating these swithces into protocells, such as the protection of these circuits against degradation, the ability to create gradients and as a delviery method for in vivo application. DNA protocells that (i) have the ability to recognize proteins and small molecules and (ii) amplify signals and generate output that alters cell physiology have not yet been developed. Realizing these structures requires filling a gap in our knowledge of how of how aptamer reactions network in confinement. We anticipate that by filling these gaps in our knowledge, we will be able to produce a pure DNA protocell that can harbor aptamer-based response networks for modulation of intercelullar communication in the tumor microenvironment.

Keywords: dna protocell,aptamer,tumor microenvironment,self assembly,dna computing,nucleic acids,cell communication
Responsible Link-Recommendations in Dynamic Environments (RE-LINK)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

This proposal aims to develop, for the first time, new computational models to systematically evaluate 1) the long-term societal impacts of link-recommendation algorithms in online social networks and 2) design a new paradigm of link-recommenders that incentivize cooperation, collective action, and misinformation control. It is urgent to understand how algorithms used in online social media impact human behavioural dynamics given the widespread use of social media platforms and the evidence that they contribute to exacerbate radicalization, misinformation, and incite hate. This is a challenging endeavour. Online platforms are nowadays complex ecosystems where millions of humans influence each other while co-existing with AI algorithms. In this context, link-recommendation algorithms, used to recommend new connections to users, are ubiquitous. Such algorithms fundamentally affect how new connections are formed and the information users are exposed to. Governing online social networks requires understanding the impact of link-recommenders and how to adapt them to ensure long-term benefits. With RE-LINK, I aim to develop a new class of models to understand the impact of link-recommendations on social dynamics and, in turn, design a new paradigm of algorithms that balance short-term performance and long-term societal benefits. This will be achieved by developing agent-based models where the evolution of behaviours occurs over adaptive networks whose growth, in turn, follows the heuristics used by link-recommenders. I will resort to evolutionary game theory and stochastic population dynamics to formally study the stability of behaviours in this setting. I will use the modelling results to design new link-recommenders that contribute to stabilize positive social behaviours such as cooperation, collective action, and misinformation debunking. The developed algorithms will be evaluated with large-scale multi-agent simulations, online experiments, and real-world data.

Keywords: multi agent systems multi agent simulation agent based modelling complex networks network science evolutionary game theory
Multi-sensory, User-centred, Shared cultural Experiences through Interactive Technologies (MuseIT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on the European Cultural Heritage and the Cultural and Creative Industries
Action type: Research and Innovation actions
Countries involved: Sweden,Cyprus,Greece,United States,United Kingdom,Belgium,Italy,Netherlands
Call: Preserving and enhancing cultural heritage with advanced digital technologies (HORIZON-CL2-2021-HERITAGE-01, 2021)
Start date: 2022-10-01
End date: 2025-12-31
Duration (months): 39.0
Total project cost (EUR): 3358745.0
EU funding (EUR): 3358745.0
Participants: 12
Project status: SIGNED

Advancements in digital transformation have enriched the interactive experience of cultural heritage. The adoption of digital technologies has benefited the development of virtual museum tours, preservation of cultural assets, digitised archives enabling broader and engaging means of access to cultural heritage. Despite critical advances, structural deficiencies remain: lack of accessibility for all; limited opportunities for all members of society to participate in cultural and creative industries on equal basis; and limited interoperable digital repositories for archiving accessible multisensory cultural assets and related archival structures. With one billion people experiencing some form of disability and one-fifth of these experiencing significant disabilities, access or opportunities to engage with cultural assets is not equally available to all. MuseIT aims to co-design, develop, and co-evaluate a multisensory, user-centred platform for enriched engagement with cultural assets with inclusion and equal opportunity for all as core principles. The MuseIT innovation is rooted in multisensory representations of cultural heritage which extend beyond the visual and auditory senses. More specifically, MuseIT will: a) co-design and develop multisensory representations and rendering of cultural assets, b) develop services for inclusive remote co-creation of multi-modal born-digital cultural assets, and c) develop formal specifications and strategies for inclusive archival preservation of cultural heritage. Participatory co-design activities will be integral to enable users with disabilities to be involved in decisions and designs that will affect their lives. Enriched experiences of cultural assets created by MuseIT will not be limited to this group and is likely to enhance the level of participation and enjoyment for all people. Impacts are likely to include the democratization of cultural asset experiences, and tangible growth in creative and cultural industries.
Support to the Vice-Presidents of the ERC Scientific Council 2023 (ERC VP CSA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: ERC other
Action type: Coordination and support actions
Countries involved: Denmark
Call: Support to the Vice-Chairs (HORIZON-ERC-2022-VICECHAIRS-IBA, 2022)
Start date: 2023-01-01
End date: 2023-12-31
Duration (months): 12.0
Total project cost (EUR): 298521.25
EU funding (EUR): 298521.25
Participants: 1
Project status: CLOSED

The European Research Council (ERC) provides a competitive platform for investigator-driven frontier research at the European level. It is led by a Scientific Council (ScC) consisting of 21 eminent scientists and their President, and it is this council that independently establishes and oversees the ERC's scientific management and the implementation of its Work Programme. This project aims to support the ERC Vice-Presidents, who act on an honorary basis, in the efficient and timely achievement of the ScC's goals in 2023. This project will provide local administrative and advisory support to the three ERC Vice-Presidents. The staff supported by this project will provide analysis of the output of the ERC and the ScC to the Vice-Presidents, preparatory work for the meetings of the ScC, support with scientific outreach and representation, as well as maintaining a clear and efficient channel of communication between the Vice-Presidents and the ERC's Executive Agency. A key duty of the Vice-Presidents is maintaining the integrity of the ERC's evaluation panels, and the staff supported by this grant will facilitate this by providing detail information and analysis of potential panel members to the Vice-Presidents to allow them to take informed decisions on recruitment. The staff will also coordinate the invitation of new panel members and communicate with them during the recruitment process. The impact of the project will be to ensure the efficient and well-managed operation of the ScC. This support is required, as the duties of the Vice-Presidents demand a considerable portion of their time. By allowing the Vice-Presidents to effectively and efficiently perform their duties, this project will contribute significantly to the continued implementation of the ERC under Horizon Europe.

Keywords: erc scientific council,advisory support,administrative support,panel member recruitment,scientific outreach,liaison with the erc executive agency
Resolving mechanisms of microbiome rescue to promote resilience to climate change (MicroRescue)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2272881.25
EU funding (EUR): 2272881.0
Participants: 1
Project status: SIGNED

Earth’s climate crisis threatens to disrupt ecosystem services and destabilize food security. Communities of microorganisms, called microbiomes, provide critical functions that feedback on climate and support soil and plant health. I propose a new framework, Microbiome Rescue, to recover microbial populations and lost functions after disturbances. With critical knowledge about the ecology of microbiomes and their contributions to creating resilient systems, I propose that we can achieve a paradigm shift in ecosystem management via directed microbiome interventions. Here, I focus on elaborating rescue strategies that leverage the selective reactivation of dormant microbes. Because microbial dormancy is extensive in soil and the rhizosphere, reactivation offers access to untapped biodiversity and provides immediate solutions for maintaining functions in ecosystems affected by climate change. My first objective is to understand and predict the capacity of dormant soil microorganisms to rescue microbiomes in a changing climate and discover reactivated bacteria that facilitate resilience. My second objective is to investigate and develop bacterial reactivation for rescue-based microbiome management to support plant resilience to climate change stressors and preserve plant-soil feedback. To achieve these goals, I will execute three multi-factor experiments to reactivate the dormant microbiome from soil and plant systems after exposure to heat and moisture stress. First I will perform a heat and moisture experiment for European soils, assess risk, and curate microbial collections that support functional rescue. Next I will perform two practical rescue experiments for the microbiomes of legumes exposed to heat and moisture stress: customized microbiological amendments and host-microbiome engineering. This work will provide unprecedented insights into microbiome rescue and identify targets for biological interventions to support soil and crop resilience to climate change.

Keywords: resilience,metagenomics,disturbance ecology
Targeting RNA with small molecules (TargetRNA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Norway,Denmark,Germany,France,Italy,Sweden,Netherlands,United Kingdom,Switzerland
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-09-01
End date: 2028-08-31
Duration (months): 48.0
Total project cost (EUR): 4407773.14
EU funding (EUR): 4281897.6
Participants: 17
Project status: SIGNED

RNA molecules play key roles in biological processes and diseases. An emerging avenue to develop innovative medicines is therefore to design small molecule drugs that bind to RNA and affect downstream biological functions. However, to advance this field of research, a new generation of scientists is needed that can further develop and ultimately master the challenging process of drug design applied to RNA. Therefore, the TargetRNA network aims to educate and nurture the next generation of scientists with cutting-edge interdisciplinary skills in the discovery and biological characterization of RNA modulators and thus generate fundamental knowledge on what drives affinity and specificity of small molecules binding to RNA. The objective of TargetRNA is to develop compounds with antimicrobial activity through their interaction with RNA targets, and to use these to selectively reshape the human gut microbiome, an area with vast implications for medicine. Training through research activities, spanning from computational and medicinal chemistry over structural and molecular biology to microbiology and in vivo models, will be supplemented by an innovative training programme in specific and transferable skills for interdisciplinary drug discovery strategies to target RNA, including FAIR data principles, open science practices as well as responsible development and sustainable implementation of new innovations. To achieve the ambitious research and training goals, the TargetRNA network unites leading scientists from 13 academic partners (8 beneficiaries, 5 associated) and 4 industry partners (1 beneficiary, 3 associated) based in 9 countries.