Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Transformation of emerging contaminants in the aquatic environment. Fate of transformation products under multiple stress conditions (TRANSFORMER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-11
End date: 2016-08-23
Duration (months): 15.0
Total project cost (EUR): 106326.0
EU funding (EUR): 106326.0
Participants: 1
Project status: CLOSED

Pharmaceutically active compounds (PhACs) are a special class of contaminants because they can undergo transformations through metabolism before their entrance into aquatic and terrestrial environments. Once they reach the environment they are further transformed by abiotic and/or biotic transformation processes and understanding of transformation pathways and identification of transformation products (TP) is a prerequisite for a thorough assessment of their environmental risk. This project proposes the use of Experimental Stream Facility (artificial rivers), a unique facility available at ICRA that will permit simultaneous study of biodegradation, photolysis, and adsorption /desorption processes under different situations, such as intermittent flow (drought), temperature or light fluctuations, among others. State of the art hybrid and high resolution mass spectrometric instrumentation will be used to study transformation pathways and provide a comprehensive and detailed profile of TPs formed. By using an integrated approach and simultaneous study of biotic and abiotic transformation processes TRANSFORMER’s main expected results are: (i) elucidation of transformation pathways (biological and photo induced) and identification of main TPs from a number of relevant pharmaceuticals (including some understudied and, for the first time, a new class pharmaceuticals such as peptidomimetics and peptide therapeutics); (ii) determination of partition coefficients (water-sediment and water-biofilm) of the studied pharmaceuticals and TPs and (iii) identification of potential controlling factors and mechanisms behind in-stream attenuation of pharmaceuticals (biodegradation vs photodegradation vs sorption). Accordingly, we expect that the results produced by this innovative research plan will have substantial impact on the field of inland water research, one of the Europe’s Societal Challenges.

Keywords: pharmaceuticals,biotic and abiotic trasformation,transformation products,elucidation of transformation pathways
Innovative System for Electrical Energy Efficiency in industrial plants (EFICONSUMPTION)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-2-2015, 2015)
Start date: 2016-02-01
End date: 2018-01-31
Duration (months): 24.0
Total project cost (EUR): 1288625.0
EU funding (EUR): 902037.5
Participants: 1
Project status: CLOSED

EFICONSUMPTION project is focused on the development, industrialisation and further commercialization of a disruptive system able to reduce the electricity consumption in industries in a percentage up to 40%, expressed in terms of unitary energy cost. These savings can be achieved, by means of a new system for optimal power electric measurement, real-time monitoring, smart energy modelling, remote control and horizontal scalable management of industrial plant production and service processes. The new solution is a combination of a specific device able to measure the main electricity parameters at any place, and an expert system, which will receive the real time data and will be able to establish efficient consumption patterns to effectively reduce the electricity consumption, in accordance with the international standard ISO 50001. This reduction will also contribute to reduce carbon footprint and emissions. The system consist of a M2M network of smart devices to measure and manage the main electricity parameters at any cable position of a plant or building by sending data and receiving optimal models of consumption from an ICT Big Data platform, able to establish efficient consumption patterns in real-time. The system has a huge business potential thanks to unique features as electrical modeller, energy saver, safety and quality controller that can be adapted to several industrial sectors and to different types of facilities. The innovative character of the proposed solution is based on the portability of the measuring devices, the simple network integration of the devices and ability to scale the system to cover a very complex network as well as the simplicity for non-professional users. The new energy management standard ISO 50001 will increase the need of EFICONSUMPTION, representing the best practice in energy management, aiming at helping companies to adopt a policy, identify significant areas of energy consumption and target reductions

Keywords: electricity consumption,efficiency,measurement,metering,energy,emissions,industries,real time modelling,exploitation plan,business,commercialization,feasibility study,market analysis
reDucing the health and Economic COst of Diagnostic uncErtainty: establishing potential applications of BV™ and its composite biomarkers in COVID-19 detection and patient management (DECODE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 3571427.3
EU funding (EUR): 2499999.11
Participants: 1
Project status: CLOSED

Problem: Clinicians routinely face diagnostic uncertainty because acute infections are often clinically indistinguishable and today’s diagnostics have constraints. This uncertainty leads to inappropriate patient management, including antimicrobial misuse and avoidable hospitalization. The associated health economic burden are inferior patient outcomes, elevated costs, and antimicrobial resistance (AMR), one of the top 10 threats to global health. Potential solution: In many instances, the clinician only needs to know with confidence if the infection is bacterial or viral to decide how to manage a patient suspected to have an acute infection. We have developed and validated MeMed BV™ - a pioneering test for distinguishing between bacterial and viral infections that decodes the body’s immune response to infection. BV™ has been both double-blind and externally validated in clinical studies enrolling thousands of patients and demonstrated superiority to biomarkers in routine use. Concurrently, we have developed Key™, an easy-to-use POC platform that runs BV™ in 15 minutes. To establish potential applications of BV™ and its composite biomarkers in managing COVID-19 patients, the following objectives are proposed: 1. To deploy BV™/Key™ at hospitals in Israel, Germany and Italy that are managing COVID-19 patients. 2. To collect real world evidence to support the performance of BV™ in identifying early viral infection and predicting/monitoring disease severity of COVID-19 disease. 3. To mature the BV™/Key™ system based on lessons learned during deployment. Impact: Fulfilment of Objectives 1 and 2 will pave the way to full EU commercialization of the BV™ biomarkers as an aid in COVD-19 patient management. Obtainment of Objective 3 will mature the BV™/Key™ system in readiness for a wider launch to support the fight against COVID-19. Taken together, the efforts of this project will take BV™ on Key™ from a regulatory cleared test to one that is available commercially and adopted in routine care and is ready for broader launch. By providing an actionable tool that reduces diagnostic uncertainty, this project will improve patient outcomes while reducing healthcare costs and help fight AMR.

Keywords: host based bacterial versus viral test,point of care diagnostic system,antimicrobial resistance
Smart Textiles for RETrofitting and Monitoring of Cultural Heritage Buildings (STRETCH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: SIGNED

This project aims to develop novel techniques using smart multifunctional materials for the combined seismic-plus-energy retrofitting, and Structural Health Monitoring (SHM) of the European cultural heritage buildings (CHB). The need for upgrading the existing old and CHB is becoming increasingly important for the EU countries, due to: (1) their poor structural performance during recent earthquakes (e.g. Italy, Greece) or other natural hazards (e.g. extreme weather conditions) that have resulted in significant economic losses, and loss of human lives; and (2) their low energy performance which increases significantly their energy consumption (buildings are responsible for 40% of EU energy consumption). Moreover, the SHM of the existing buildings is crucial for assessing continuously their structural integrity and thus to provide information for planning cost effective and sustainable maintenance decisions. Since replacing the old buildings with new is not financially feasible, and even it is not allowed for CHB, their lifetime extension requires considering simultaneously both structural and energy retrofitting. It is noted that the annual cost of repair and maintenance of existing European building stock is estimated to be about 50% of the total construction budget, currently standing at more than €300 billion. To achieve cost effectiveness, STRETCH explores a novel approach, which integrates technical textile reinforcement with thermal insulation systems and strain sensors to provide simultaneous structural-plus-energy retrofitting combined with SHM, tailored for masonry cultural heritage building envelopes. The effectiveness of the proposed retrofitting system will be validated experimentally and analytically. Moreover, draft guidelines and recommendations for determining future research on the use of smart composite materials for the concurrent retrofitting (structural-plus-energy) and SHM of the existing cultural heritage buildings envelopes will be proposed.

Keywords: cultural heritage buildings,advanced materials,seismic retrofitting,energy retrofitting,structural health monitoring,masonry buildings,optical fibre sensors
Millimetre-Wave Based Mobile Radio Access Network for Fifth Generation Integrated Communications (mmMAGIC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Future Internet: Software, hardware, Infrastructures, technologies and services
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Spain,Finland,Sweden,Poland,Sweden,France,United Kingdom,Denmark,United Kingdom
Call: Advanced 5G Network Infrastructure for the Future Internet (H2020-ICT-2014-2, 2014)
Start date: 2015-07-01
End date: 2017-06-30
Duration (months): 24.0
Total project cost (EUR): 8165085.0
EU funding (EUR): 8165084.0
Participants: 20
Project status: CLOSED

The mmMAGIC (Millimetre-Wave Based Mobile Radio Access Network for Fifth Generation Integrated Communications) project will develop and design new concepts for mobile radio access technology (RAT) for mm-wave band deployment. This is envisaged as a key component in the 5G multi-RAT ecosystem and will be used as a foundation for global standardization. The project will thus enable ultrafast mobile broadband services for mobile users, supporting UHD/3D streaming, immersive applications and ultra-responsive cloud services. The consortium brings together major infrastructure vendors (Samsung, Ericsson, Alcatel-Lucent, Huawei, Intel, Nokia), major European operators (Orange, Telefonica), leading research institutes and universities (Fraunhofer HHI Institute, CEA-LETI, IMDEA Networks, Universities Aalto, Bristol, Chalmers and Dresden), measurement equipment vendors (Keysight Technologies, Rohde & Schwarz) and one SME (Qamcom). To complement its strong industry leadership and academic excellence, the project has an Advisory Board drawn from major European telecommunications regulators in Germany, France, Finland, Sweden and the UK. A new radio interface, including novel network management functions and architecture components will be proposed, taking as guidance 5G PPP’s KPI and exploiting the use of novel adaptive and cooperative beam-forming and tracking techniques to address the specific challenges of mm-wave mobile propagation. The project will undertake extensive radio channel measurements in the 6-100 GHz range, and will develop and validate advanced channel models that will be used for rigorous validation and feasibility analysis of the proposed concepts and system, as well as for usage in regulatory and standards fora. The ambition of the project is to pave the way for a European head start in 5G standards, including 3GPP, and to secure essential IPRs to European industry, strengthening European competitiveness.

Keywords: key words cellular,mobile communications,millimeter wave communications,radio spectrum,air interface,multi antenna,channel modelling,architecture,standards
Defective protein translation as a pathogenic mechanism of peripheral neuropathy (CMTaaRS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-06-01
End date: 2024-05-31
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Familial forms of neurodegenerative diseases are caused by mutations in a single gene. It is unknown whether distinct mutations in the same gene or in functionally related genes cause disease through similar or disparate mechanisms. Furthermore, the precise molecular mechanisms underlying virtually all neurodegenerative disorders are poorly understood, and effective treatments are typically lacking. This is also the case for Charcot-Marie-Tooth (CMT) peripheral neuropathy caused by mutations in five distinct tRNA synthetase (aaRS) genes. We previously generated Drosophila CMT-aaRS models and used a novel method for cell-type-specific labeling of newly synthesized proteins in vivo to show that impaired protein translation may represent a common pathogenic mechanism. In this proposal, I aim to determine whether translation is also inhibited in CMT-aaRS mouse models, and whether all mutations cause disease through gain-of-toxic-function, or alternatively, whether some mutations act through a dominant-negative mechanism. In addition, I will evaluate whether all CMT-aaRS mutant proteins inhibit translation, and I will test the hypothesis, raised by our unpublished preliminary data shown here, that a defect in the transfer of the (aminoacylated) tRNA from the mutant synthetase to elongation factor eEF1A is the molecular mechanism underlying CMT-aaRS. Finally, I will validate the identified molecular mechanism in CMT-aaRS mouse models, as the most disease-relevant mammalian model. I expect to elucidate whether all CMT-aaRS mutations cause disease through a common molecular mechanism that involves inhibition of translation. This is of key importance from a therapeutic perspective, as a common pathogenic mechanism allows for a unified therapeutic approach. Furthermore, this proposal has the potential to unravel the detailed molecular mechanism underlying CMT-aaRS, what would constitute a breakthrough and a requirement for rational drug design for this incurable disease.

Keywords: peripheral neuropathy,trna synthetase,non canonical amino acid tagging,drosophila genetics,mouse genetics
Electrically pumped network random lasers (EPNRL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-16
End date: 2020-07-15
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Random lasers based on disorder and multiple scattering are alternative means to generate laser light. Although random lasers have been studied for over thirty years, very few practical applications utilizing random lasers have been realised. The main difficulty with random lasers has been achieving electrical pumping with high conversion efficiency and obtaining directional beam output. Resolving these difficulties will make random lasers practical and will open up many new applications, such as in optical computing and image projection. In this project we propose to develop an electrically pumped network random laser. This new type of laser will have high conversion efficiency and directional beam output, and can be easily integrated on a chip with waveguides. This project is at the cross-roads of nanophotonics, complex systems and network science, and thus is quite multi-disciplinary in nature. Results from this project will be technologically significant and will enable rapid commercialisation of random lasers, which has thus far been limited.

Keywords: random lasers,network lasers,semiconductor laser diodes,photonic integration
Mapping the neuronal representation in dorsal inferior colliculus through optical imaging, stimulus optimization and optogenetics (OPTIMAPIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-03-01
End date: 2017-02-28
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Despite being the most accessible subcortical auditory structure, little is known about the dorsal cortex (ICd) of the inferior colliculus. Limited physiological evidence hints at functions regarding detection of frequency-modulation, novel sounds and selective attention. This project tries to address three fundamental questions regarding the ICd, namely: (1) what are optimal stimuli for the neurons in the ICd, (2) why is the neuronal activity in ICd important for the organism and (3) how does the neuronal circuit achieve the necessary computation. Taking advantage of state-of-the-art in vivo optical imaging, I will search for effective stimulus features through a population-wide stimulus optimization approach (WP1). The ability to measure neuronal activity over weeks expands the range of sound stimuli researchers can deliver, providing a basis for a more unbiased stimulus search. Moreover, groups of cells that respond to similar features can be detected, while extra efforts can be diverted towards identifying optimal stimuli for the remaining cells. Secondly, a behavioural paradigm will be developed to probe the effect of selective attention on neuronal activity of the ICd (WP2). At the same time, comparing neuronal and behavioural response will help us understand how neuronal representations translate into percept and actions of the animal. Finally, I will investigate how neuronal activities in the ICd are shaped by projections from other brain regions, through the imaging of synaptic terminals from these inputs and, subsequently, optogenetic manipulations. The results will lead to a major understanding in the sensory processing at the auditory midbrain and the functional significance of its interactions with other brain regions. These research outcomes are not ends in themselves, but will provide the Fellow with a basis for further research as an independent group leader.
Specialized Help from Be My Eyes – harnessing technology to connect companies directly with their blind and visually impaired users (BEMYEYES)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-09-01
End date: 2020-11-30
Duration (months): 15.0
Total project cost (EUR): 1545100.0
EU funding (EUR): 1081570.0
Participants: 1
Project status: CLOSED

For the 25 million blind and visually impaired people within the EU, simple everyday tasks, present a daunting challenge that can leave them dependent on the help of relatives and carers and there is a very narrow set of options focused at facilitating their daily lives. This challenge is exacerbated by the small number of companies who adapt their services to the needs of blind and visually impaired users compared to the rest of their customers. Specialized Help from Be My Eyes will build on our existing award-winning digital crowdsourcing app ‘Be My Eyes’ to connect our existing visually impaired user base of 100,000 individuals to customer support functions in subscribing companies. Be My Eyes is in the unique position of being able to provide both the technology and the users to companies who subscribe to our service allowing them to service the visually impaired community, improve their CSR and accessibility agendas and gain relevant product feedback through a single, integrated user platform. Specialised Help will be developed to a fully commercialised product meeting the customer needs as determined by a SME Instrument Phase 1 Feasibility Study. We estimate that within 5 years of product launch we will have sold 185 Specialized Help licenses achieving revenues of €54.3m. We will have hired 30 additional new employees and will control 4.7% of the European market. The return on the project investment in the third year of commercialisation would be 16.98.

Keywords: customer service,customer support,blind,visually impaired,interface,visually adaptive,help desk,artificial intelligence,human robot machine learning