Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Developing sustainable, high performance polyurethanes with chemical circularity (PolyRec)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-07-01
End date: 2025-06-30
Duration (months): 36.0
Total project cost (EUR): 261380.64
EU funding (EUR): 261380.64
Participants: 2
Project status: CLOSED

Since the development of the first fully synthetic plastics in the early 20th century, these materials have become ubiquitous in our daily life. The production of plastics has increased considerably, reaching 368 million tons in 2019 and it is expected to double again by 2035. Today’s plastics are designed for performance, cost and durability without taking into consideration their life after use. This has resulted in an annual generation of plastic solid waste of 150 million tonnes. Tackling plastic waste problem is one of the top priorities yet most challenging objectives of the European Union, which has set ambitious policies (i.e. Green Deal) and aims to recycle 50 % of all post-consumer plastics by 2025. The design of plastics with recyclability built into their performance aiming for a circular plastics economy is gaining a lot of attention. With specifically designed monomers, reaction conditions can be used to select the direction of the monomer-polymer equilibrium. Therefore, chemical recycling to monomer presents an attractive alternative since the polymer waste is employed to close the loop in a circular economy process that recovers the economic value of the material. Through PolyRec, Dr. Ainara Sangroniz proposes to tackle this growing global challenge, by developing high-performance polyurethane (PU) plastics that exhibit a closed-loop circular lifecycle while also having performance properties comparable to those of today’s poorly or non-recyclable commodity plastics. In the outgoing phase, the fellow will develop an innovative class of intrinsically recyclable PUs at the Colorado State University under the supervision of Porf. Eugene Y. X. Chen. In the incoming phase, these will then be depolymerized into their building block monomers and repolymerized back into the PU’s at POLYMAT (University of the Basque Country), supervised by Prof. Haritz Sardon.

Keywords: green chemistry,recycling
Exploring unregulated contaminants in the Mediterranean diet; A first insight into the safety of this Intangible Cultural Heritage (MDietSafe)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: SIGNED

Food ingestion plays a significant role in human exposure to environmental contaminants, resulting in health implications. Specific legislative measures control internationally the occurrence of chemicals in food to ensure consumer protection. However, there is strong evidence that there are many uncontrolled sources (e.g., deposition of particulate matter, biotic uptake and accumulation from contaminated soil or water, etc.), that may contaminate fresh and unprocessed food with unregulated contaminants. MDietSafe aims to explore the occurrence of unregulated contaminants in fresh and unprocessed food ingredients typically consumed in the Mediterranean diet (MDiet) and evaluate their potential as an exposure source for humans. For this purpose, suspect analysis of contaminants will be undertaken in a variety of food ingredients, produced in the seven Mediterranean diet countries (Portugal, Spain, Italy, Greece, Morocco, Cyprus, and Croatia) using a novel and simple approach based on the combination of supramolecular solvents with liquid chromatography coupled with high-resolution mass spectrometry (SUPRAS-LC-HRMS). The generated data will be used for human health risk estimation using different hazard indexes. Results from MDietSafe will give a first insight into the current status of unregulated contaminants in MDiet, thus providing a starting point for taking corrective measures if necessary. MDiet is worldwide recognized as a source of health for consumers, so keeping it safe from contamination is essential for guaranteeing this intangible cultural heritage and the associated traditional and cultural assets. MDietSafe is in line with the European mission for food safety and security, deepening the knowledge of the contribution of unregulated contaminants to human exposure through food. MDietSafe also addresses the UN-SDG 2, which aims to achieve food security, improve nutrition, and promotion of sustainable agriculture.

Keywords: unprocessed food mediterranean diet unregulated contaminants supramolecular solvents suspect screening exposure risk estimation
Studying hybrid speciation and introgression using a natural fungal model system (FINESSE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 251578.56
EU funding (EUR): 251578.56
Participants: 1
Project status: SIGNED

Hybridisation, mating between distinct species or divergent populations, can lead to a variety of different outcomes. Many hybrid offspring will have low fitness or be inviable, while others may increase fitness under extreme conditions by producing transgressive hybrids with phenotypes outside of their parental range. The role of hybridisation in adaptation and speciation is a key question in evolutionary biology, especially as hybridisation is predicted to rise due to climate change and other human activities. In FINESSE (Fungal INtrogrESsion and SpEciation) we aim to use the wood-decaying fungus Trichaptum abietinum as a study system for researching hybridisation. In Europe, there are three distinct populations of T. abietinum: a Mediterranean population, a Boreal, and an Atlantic population. Where populations overlap, there are different hybrid outcomes with hybrids found in central Europe but not Norway. These contrasting outcomes make our system ideal to study patterns of introgression and hybridisation in Europe. During FINESSE we plan to 1) gather and sequence field samples from underrepresented regions across Europe, both to explore the diversity of these populations in Eastern Europe and identify the origin of the Atlantic population in Norway. 2) Generate hybrids in the lab to help us understand the differing hybrid outcomes found in Europe, and identify mechanisms of hybrid incompatibility through genomic and phenotypic assays. 3) Use a reverse genetics approach to identify genes associated with hybrid incompatibilities, using CRISPR-Cas9 transformation of candidate genes. I will also use the project to improve both my scientific and transferable skills by taking courses, from other researchers in the department, during management of the project, and more generally from working on the project. Overall, this project will let me gain the skills necessary to become a more independent researcher and improve my future career prospects.

Keywords: hybridisation,speciation,genomics,postglacial migration,genetics,crispr cas9,evolution,adaptation
Deciphering the intrinsic and extrinsic mechanisms shaping aging and leukemic evolution of hematopoietic stem cells at the single cell level (PRELEUKMEC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Israel
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 200538.24
EU funding (EUR): 200538.24
Participants: 1
Project status: CLOSED

Clonal Hematopoiesis (CH) is an age related state in which a single and genetically defined Hematopoietic Stem Cell (HSC) contributes more than expected to the hematopoietic pool, due to the selective advantage conferred by genetic variants termed preleukemic mutations (pLMs). CH is a significant risk factor for hematological malignancies such as Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS). Today, the mechanisms by which pLMs provide selective advantage and why in some cases clones become leukemic is not fully understood. This project focuses on understanding the dynamic changes that occur in human HSCs in aging and disease at the single cell level. Specifically, we wish to answer the following questions: 1) What are the functional consequences of aging on peripheral blood HSCs 2) what are the functional consequences of pLMs in CH, but also in AML and MDS in humans? 3) which microenvironmental factors provide selective advantage to the mutated clones? To answer these questions, we aim at developing a new innovative approach that will allow us to interrogate thousands of single HSCs from young/old/CH/AML/MDS patients to extract their genotype and their dynamic expression profiles at different time point of differentiation, under different culture conditions. This project will be performed in the Weizmann Institute, one of the world’s leading multidisciplinary basic research institutions in the natural and exact sciences. It will be highly interdisciplinary as it will involve collaboration with renown researchers from the Computer Science and the Chemistry department. In addition to the knowledge acquired in the lab and through the different collaborations, the fellow will benefit from high level training through attendance of various courses, seminars and international conferences. Overall, this project should have great benefit for the career of the fellow.

Keywords: hematopoiesis,aging,single cell rna seq,preleukemic mutations
Proving Offshore Wave EneRgy Farms in Europe (POWER-Farm EU)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Sweden,Portugal,United Kingdom,Belgium
Call: Demonstration of sustainable wave energy farms (HORIZON-CL5-2024-D3-01, 2024)
Start date: 2026-01-01
End date: 2031-12-31
Duration (months): 72.0
Total project cost (EUR): 30002898.75
EU funding (EUR): 18999892.35
Participants: 7
Project status: SIGNED

Led by CorPower Ocean, the POWER-Farm EU team will deploy the world’s largest ever wave energy farm – a 2.5MW installation composed of 7 world-leading CorPower wave energy convertors (WECs) – in the highly energetic North Atlantic ocean. This will de-risk wave energy technology, making it insurable and bankable, so that it can be deployed at large scale and play a significant role in decarbonising the EU's energy supply and advance energy security. The project will translate the EU's technology leadership in ocean energy into supply chain dominance by helping scale EU supply chain capacity, supporting strategic autonomy. The project builds on results from CorPower’s structured development programme, which has seen an individual WEC demonstrated in open-sea in Northern Portugal since 2023. Multiples of these WECs will be demonstrated along with farm-level demonstration of control systems, electrical architecture, anchoring, and offshore operations and maintenance methodologies. The farm's WECs will be derisked and optimised at CorPower’s dry testing facilities in advance of ocean deployment. Following this, the team will deploy the farm at the European Marine Energy Centre, the world’s leading test site for wave energy technology, which has existing onshore and offshore electrical infrastructure to connect the farm to the grid, and is pre-consented for wave energy technologies. It will operate for 15 years. The project will also demonstrate a step-change in volume manufacturing of wave energy devices, and develop capacity to service 100s of MWs of wave energy projects by the end of the project. The team will develop a pipeline of wave energy projects to enable commercialisation and support supply chain development. The project will incorporate a best-in-class environmental monitoring programme, gathering knowledge on the impacts of wave energy farms for the first time.

Keywords: wave energy,wave power,wave,offshore wave energy
Behavioral state-dependent effects of electrical stimulation on neuronal activity (ELECTRONEUROSTIM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: CLOSED

Techniques to deliver electricity to the human brain have been applied in an attempt to restore brain functions or modify behavior. Yet, many fundamental questions remain. First, it is unclear how to design stimulation protocols that lead to reliable stimulation outcomes. Second, it is challenging to define a stimulation protocol that could modify behavior without a clear understanding of the dynamic interplay between brain regions during complex behaviors. Finally, one of the goals of stimulation is to induce effects that outlast the stimulation period but whether and how lasting effects are induced is still unclear. As a first step to tackle some of these issues, the proposed project aims at understanding how electrical stimulation affects the activity of neuronal population in-vivo and whether behavioral states modulate such effects. Here I plan to use mice to bridge neuronal and behavioral levels combining highly controlled behavioral paradigms with recordings of neuronal activity at high spatial resolution during electrical stimulation applied using cutting-edge technologies. I will also implement computational models to understand the mechanisms of action of electricity on neuronal activity and to guide further experiments. Insights from this work will shed light on the realm of possible effects of electrical stimulation, and on how brain activity could be shaped to achieve specific behavioral outcomes. Ultimately, this knowledge may lead to the rational design of stimulation protocols that could be applied in humans, ideally non-invasively, to restore brain functions.

Keywords: electrical stimulation,calcium imaging,electrophysiology,behavior,mouse
Local-to-global Expansion and PCPs (LEAP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 2105840.0
EU funding (EUR): 2105840.0
Participants: 1
Project status: SUSPENDED

This proposal aims to delve further into the study of Probabilistically Checkable Proofs (PCPs), a cornerstone of modern theoretical computer science, that exhibits some of the most powerful local to global behavior. Any NP proof can be written in a format that is locally testable, meaning that local pieces of the proof imply very rich global structure. This theory is strongly tied to hardness of approximation and has significant applications in cryptography. A major goal is to develop simpler and more efficient PCP constructions, with better parameters, as well as to deepen our understanding of robust encodings with local to global features, such as PCPs. The main methodology of this exploration will be through harnessing the power of the beautiful emerging theory of high-dimensional expansion (HDX). Generalizing the concept of expander graphs to higher dimensions, HDX emerge as an exciting cross-disciplinary theory with roots in group theory, number theory, algebraic topology, combinatorics, and theoretical computer science. The HDX theory is characterized by a local-to-global principle, which allows inferences about the global structure based on local link properties. This principle bears significant potential for areas like property testing and it has already shown its power with the construction of C^3 locally testable codes. As these are very closely connected to PCPs, we seek to harness HDX towards advancing our understanding of more general local-to-global encodings, and potentially paving the way for novel PCP constructions. The research directions outlined in this proposal cover a wide array of goals, including the exploration of the HDX theory, the construction of new PCPs, inapproximability, and the creation of novel error-correcting codes. These directions seek to bridge various areas of mathematics and computer science, promising to contribute significantly to the field and open up new horizons for further research and applications.

Keywords: error correcting codes,high dimensional expansion,local testability,pcps,robustness
VET PARTICIPATION, RETENTION, AND EDUCATIONAL POLICIES IN THE WAKE OF COVID 19 – A CROSS-COUNTRY EXPLORATION (VETPREP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Denmark,Spain,United Kingdom,Croatia,Estonia
Call: Effective education and labour market transitions of young people (HORIZON-CL2-2024-TRANSFORMATIONS-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 2851586.25
EU funding (EUR): 2851586.25
Participants: 6
Project status: SIGNED

The VETprep project seeks to understand and address the challenges in Vocational Education and Training (VET) related to student identification, participation, and retention across various European contexts, focusing on students from diverse backgrounds. It examines the impact of the Covid-19 pandemic on the sector and explores policies and strategies in Croatia, Denmark, Estonia, Scotland, and Spain through comparative studies. Utilizing a multidisciplinary approach and mixed methods, the project investigates factors affecting VET student engagement, including demographics and socio-economic backgrounds, by analyzing longitudinal data and conducting in-depth interviews with selected students. This research aims to provide insights into young people's educational paths in post-pandemic Europe, highlighting differences in socio-economic status and educational aspirations, as well as differences between the pre- and post-pandemic cohorts. VETprep’s combination of generalized knowledge and individual narratives will offer a nuanced picture of Youths in the post-pandemic Europe. Furthermore, with a comparative focus on differences across the European Countries and across different young people according to socioeconomic status, academic achievements, etc., we get the opportunity to understand both the consequences and relevant actions in the light of individual differences and varying societal, political, and educational frameworks in the five European countries. The project aims to help policymakers and other stakeholders (a) meet their obligations under the EPSR (everyone has the right to quality and inclusive education, training and lifelong learning, including reducing the NEET rate to 9% by 2030) (b) implement the Council Recommendation on VET for sustainable competitiveness, social fairness and resilience (c) meet the goals of Pathways to School Success, including reducing Early Leaving from Education (d) meet UN SDGs 4, 8, 9 & 10.

Keywords: vocational education and training vet,educational transitions,student retention,student engagement,covid 19 impact,inclusive education,youth voice,vulnerable populations
Predicting the Regeneration of an Infarct by leveraging the Mechanobiology of Angiogenesis (PRIMA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Acute myocardial infarction (AMI) is a significant global health issue. Current therapies cannot regenerate the hearts of survivors, leading to frequent AMI recurrence and premature death. Crucially, these therapies fail to induce sufficient blood vessel formation, i.e. angiogenesis, which is essential to regenerate the cardiac microvasculature. Without this vasculature, cells repopulating the infarcted tissue cannot survive. A deeper understanding and better control of post-AMI angiogenesis would thus transform patient outcomes. Cells in the infarcted heart experience complex, time-evolving mechanical environments. Despite the proven role of mechanical stimuli in regulating angiogenesis in other tissues, the impact of evolving cardiac mechanical cues on post-AMI angiogenesis is unclear. With PRIMA, I aim to mechanistically understand how these evolving cues affect post-AMI angiogenesis and how to leverage this new understanding to regenerate the microvasculature. I will achieve this aim by developing a revolutionary framework featuring in vitro and in silico models of cardiac angiogenesis. These models will address the evolving mechanical cues of the infarcted heart and the cell memory of past mechanical cues (mechanical memory). The new in vitro models will expose cells to mechanical cues mimicking the cardiac tissue. The resulting insights will inform multiscale computational models to predict angiogenesis and its subcellular mechanisms in response to macroscale changes in cardiac mechanical cues. The multiscale simulations, validated by in vitro models, will finally translate the in vitro findings to the complex in vivo setting and will identify new strategies to restore the microvasculature post-AMI. Building on this unique idea and multidisciplinary approach, PRIMA will have a ground-breaking impact on cardiac interventions, by revealing mechanical cues and cell mechanoresponsive mechanisms as new targets to maximize cardiac revascularization and function.

Keywords: angiogenesis mechanobiology cardiac biomechanics computational modelling of mechanobiology