Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Bringing epigraphene nanoelectronics to life (EpigraFET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-05
End date: 2028-05-04
Duration (months): 36.0
Total project cost (EUR): 413379.72
EU funding (EUR): 413379.72
Participants: 3
Project status: SIGNED

Two decades ago, epigraphene (EG) nanoelectronics was proposed at Georgia Tech as a successor of silicon because this 2D material can exploit currently unutilized properties of charge carriers, like quantum coherence and the electronic spin, to realize faster, smaller and more energy efficient devices than is possible with silicon. In a recent breakthrough paper EG grown on a silicon carbide was shown to be a record breaking 2D semiconductor that is uniquely compatible with conventional nanoelectronics production methods. Working with the pioneers of EG, my research project proposes to demonstrate low power semiconducting epigraphene (SEG) tunnelling field effect transistors (TFET), with record breaking speeds. At GT I will grow chip-scale SEG, fabricate and optimise conventional SEG FETs, followed with development of prototype TFETs devices. SEG will be interconnected with epigraphene nanoribbons that have extraordinary ballistic transport properties of which the physics is still not well understood. This knowledge will then be transferred to Grenoble where electronic spin and quantum coherence properties will be demonstrated in intercalated heterostructures that can be incorporated in advanced SEG devices. These properties, including edge state properties will be investigated using a variety of transport and local probe techniques to provide a solid foundation for SEG nanoelectronics. This proposal has a critical scientific impact especially in elucidating the nature of the graphene edge state with quantum coherent properties easily assessable cryogenic temperatures (≈10K) and 10 micron device length scales that are relevant for practical quantum computing. The development of epigraphene nanoelectronics will revolutionize electronics, and as was successfully argued in the 1B€ European Graphene Flagship program, it will have a huge societal and economic impact for Europe. It will stimulate a worldwide SEG effort and put me at the forefront of this emerging field.

Keywords: graphene,semiconductors,2 dimensional materials,tunnel field effect transistor,epitaxial growth
3Dwheat, A 3 Dimensional functional genomics approach to identify hidden targets controlling heat stress and priming in wheat (3Dwheat)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2028-08-31
Duration (months): 72.0
Total project cost (EUR): 1999995.0
EU funding (EUR): 1999995.0
Participants: 1
Project status: SIGNED

In the global warming era, heat stress is a major threat for both yield stability and yield increase. Plants have evolved a variety of sophisticated mechanisms to adapt to challenging environments. Epigenetic regulations allow them to dynamically reprogram their transcription machinery to adapt to an ever-changing environment. Both histone marks and the 3D organization of the chromatin are instrumental for this coordinated regulation of gene expression according to environmental cues. Yet, the overwhelming majority of available data on chromatin dynamics in response to stress has been obtained in Arabidopsis, and cannot be directly transferred to crops. Due to the expansion of NGS technologies, we are currently facing a change of paradigm, empowering the development of genome-wide approaches on crops. In this project we focus on wheat. Wheat is the 1st cereal worldwide for trade, and the demand is expected to increase by 60% by 2050. My main objective is a thorough understanding of the priming for heat stress resistance in wheat. To this end, I propose to develop a new tri-dimensional (D) functional genomics approach, integrating epigenomic (1D), transcriptomic (2D) and chromatin architecture (3D) data to elucidate the molecular basis for priming in wheat. Moreover, this project will go beyond addressing the challenge of deciphering epigenetic regulatory processes underlying priming. It also includes the development of innovative tools for novel breeding strategies that will harness epigenetic variability in addition to genetic diversity. We propose to generate a new generation of molecular markers that do not rely on DNA sequence polymorphisms, and that can be readily used in traditional breeding programs as such, or as complementary tools for efficient QTL introgression. Such markers will be used to tag new traits, to follow a new generation of alleles as well as to unveil new types of genetic diversity in existing collections of germplasms.
Interstellar Chemical Evolution: Probing HCN and HNC Formation and Destruction on Icy Surfaces with Computational Chemistry (ICE-CN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 187624.32
EU funding (EUR): 187624.32
Participants: 1
Project status: SIGNED

HCN and HNC are routinely used by astronomers to trace temperature and dense gas regions in galaxies, where stars and planetary systems form. They are key precursors of complex species, including prebiotic molecules like amino acids and nucleotides. While their gas-phase formation and evolution are well understood, their formation and destruction paths on interstellar ices remains largely unchartered territory. The aim of this proposal is to remedy this knowledge gap by investigating the formation of HCN and HNC through CN radical hydrogenation on interstellar water and CO ices, as well as their destruction paths using state-of-the-art computational chemistry and astrochemical modelling. Including, in all cases, their deuterated counterparts. It also presents an opportunity to study the interaction of CN radicals with ice surfaces, which can occur either through physisorption or hemibonding on both types of ices. The four primary objectives of this proposal are: (i) to explore the CN to water and CO ice binding energy distribution as well as the dominant binding modes, (ii) to quantify the hydrogenation reactions of CN with atomic and molecular hydrogen forming HCN and HNC, as well as other possible hydrogenation products due to the hemibonding interactions, (iii) to investigate the destruction of the products in the previous point resulting from further hydrogenation reactions, and finally, (iv) to calculate the rate constants, including quantum tunnelling, and implement these in the UCLCHEM astrochemical model to assess the importance of surface chemistry in two specific cases: the shocked region L1157-B1 and the NGC1068 galaxy. The novelty of this proposal lies in the combination of computational chemistry and astrochemical modelling to unveil the ice-surface formation and evolution of HCN and HNC and their deuterated counterparts for the first time, encompassing a comprehensive characterization of the CN to water and CO hemibonding interaction.

Keywords: interstellar ice chemistry,density functional theory,astrochemical modelling,instanton theory
Dots-in-NANOWires by near-field illumination: novel single-photon sources for HYbRid quantum photonic circuits (NANOWHYR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 1499393.0
EU funding (EUR): 1499393.0
Participants: 1
Project status: SIGNED

Quantum photonic integrated circuits are ideal platforms for quantum computation and communication. A long-standing issue in their realization is the lack of a deterministic quantum light source compatible with silicon. Indeed, planar self-assembled III-V quantum dots (QDs) –which provide high-performance quantum light sources (i. e. single photons)– can hardly be grown on Si, and also lack the positioning control necessary for efficient post-growth III-V-on-Si hybrid integration. Nanowires (NWs), in contrast, are rod-shaped nanoscale semiconductors that can host intrinsically site-controlled III-V QDs and can even be grown on Si. However, QDs in NWs have yet to reach the performances of planar QDs, an issue that could be overcome by integrating QDs in NWs in photonic cavities. Such a solution is, at present, out of reach, because conventional creation of QDs during NW growth hinders their successful integration with cavities. The NANOWHYR project will allow the integration of QDs in NWs with cavities by realizing an unprecedented post-growth creation of QDs inside NWs. The new method consists of the incorporation of hydrogen in III-V nitride NWs whose bandgap can be controllably modified by hydrogen. Subsequent hydrogen removal by scanning near-field illumination will permit tuning the bandgap of the NW in a nanoscale region. This will allow us to form a QD in that region with a widely tunable energy. The deterministic control of the QD position and energy is the key that will enable us to efficiently integrate the QD with: A) planar photonic cavities fabricated on Si and B) vertical NW cavities grown on Si. This will lead to the breakthrough of a site-controlled, electrically-driven, telecom-friendly single photon source in Si photonic circuits. Moreover, this new strategy permits the modulation of semiconductor properties at the nanoscale, and it is thus expected to open new grounds in other research areas, such as photovoltaics and thermal energy converters.

Keywords: nanowires,iii v semiconductors,bandgap engineering,hydrogen irradiation,single photon emitters,quantum dots
Synthetic programmable artificial condensates for enzymatic reactions (SPACER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 247553.28
EU funding (EUR): 247553.28
Participants: 1
Project status: SIGNED

Cells contain numerous membraneless organelles, also called biomolecular condensates referring to the liquid-like properties of these condensate droplets. Intrinsically disordered proteins enrich these condensates, and the presence of enzymes makes these condensates interesting reaction crucibles. In this project called Synthetic Programmable Artificial Condensates for Enzymatic Reactions (SPACER), I propose to design such organelle that can boost an enzymatic cascade both in vitro and in vivo. For this, a synthetic condensate scaffold protein will be used inspired by a consensus repetitive sequence of resillin. Such a model offers to twitch the protein length and material properties. Using the leading technology of the lab in coiled-coil sequences, the aim is to design specific recruitment of enzymes to the scaffold using hetero-dimeric coiled coils with high affinity. These fundamental building blocks will offer a large but still manageable variety of designs to explore conditions where enzymatic activity could be boosted. Aiming to further improve this system by designing it in such a way that our synthetic condensates function in cells, it could open up doors for the production of synthetic molecules that are currently challenging to produce in cells such as yeast and e.coli.

Keywords: enzymes,biomolecular condensates,synthetic biology
Enabling Data Enrichment Pipelines for AI-driven Business Products and Services (enRichMyData)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: World-leading Data and Computing Technologies
Action type: Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Norway,Netherlands,Germany,Spain,Romania,Italy,Bulgaria,Slovenia,Denmark,China,Estonia
Call: Technologies for data management (AI, Data and Robotics Partnership) (IA) (HORIZON-CL4-2021-DATA-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 5887140.0
EU funding (EUR): 4999941.5
Participants: 14
Project status: SIGNED

enRichMyData provides a novel paradigm for building rich, high-quality and valuable datasets to feed Big Data Aalytics and AI applications. The paradigm consists in facilitating the specification and scalable execution of data enrichment pipelines, with a focus on supporting various data enrichment operations such as discovery, understanding, selection, cleaning, transformation, integration of Big Data from a variety of sources. enRichMyData makes this paradigm easily accessible to a wide set of large and small organizations that encounter difficulties in the process of delivering suitable data to feed their data analytics solutions due to the lack of suitable tools and expertise to support cost- effective and energy-efficient management of data enrichment pipelines. enRichMyData delivers a software toolbox consisting of tools and infrastructure services for setting-up, deploying, executing and managing data enrichment pipelines. The main exploitation targets the operation and monetization of the toolbox primarily in European markets. enRichMyData validates its plan through a strong selection of complementary business cases offered by commercially- focused organizations targeting development of novel products in a wide range of domains, including digital marketing, Industry 4.0, medical devices maintenance, public procurement, innovation ecosystems, and mineral processing. The balanced consortium consists of 13 partners from 11 countries. With a mixture of R&D/technology providers and business case providers, enRichMyData gathers five large companies, three SMEs, two research institutes, and three universities.

Keywords: data enrichment,data pipelines,big data,artificial intelligence,knowledge graphs
Development of a Complete Triple Action Injectable Treatment for Osteoarthritis (ARTRIGEL)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Ireland
Call: EIC Transition Open 2021 (HORIZON-EIC-2021-TRANSITIONOPEN-01, 2021)
Start date: 2022-03-01
End date: 2024-08-31
Duration (months): 30.0
Total project cost (EUR): 2398115.0
EU funding (EUR): 2398115.0
Participants: 2
Project status: CLOSED

Osteoarthritis (OA) is an incurable complex disease affecting an estimated 240 million people globally including 40 million Europeans . OA is the fastest growing cause of disability due to an aging population and the obesity epidemic and affects more people each year than cancer and heart disease. In knee OA progressive degradation of bone and cartilage in the joint results in severe pain and reduced mobility. Current treatments for Knee OA target only one aspect of the disease, yet most recent scientific data highlight the need for multi-modal therapeutics to treat this complex disease. Furthermore, the limitations of treatments force 80% of patients to rely on strong, addictive pain medication. Through the Hydrolieve ERC proof of concept grant, it was proven that Hydrobloc, statistically significantly reduced pain sensations in an in vivo pain model. These exciting results led Dr Alison Liddy to spin-out Relevium Ltd. Hydrobloc unique synergistic triple action addresses all aspects of this debilitating disease. Hydrobloc is the only therapeutic that regenerates the damaged cartilage whilst providing immediate, superior pain relief, and improving the physical function of the joint through a cushioning lubricant effect. Pre-clinical studies have proven that Hydrobloc returns the OA joint to 90% of normal (non-OA) physical function. With this EIC grant, Relevium is partnering with NUI Galway to validate the pre-clinical results in larger animals and preclinically test for other OA indications. Relevium will compile the clinical trial dossier and develop a business model towards the maturation and transition to commercialisation.

Keywords: orthobiologic,osteoarthritis,chronic pain,multimodal therapeutic,cartilage regeneration pain relief lubrication,knee osteoarthritis,chronic progressive disease,disease modifying drug
effects of Climatic extremes On eCOsystem Stability (COCOS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-10
End date: 2024-10-09
Duration (months): 24.0
Total project cost (EUR): 150438.72
EU funding (EUR): 150438.72
Participants: 1
Project status: CLOSED

Ecosystems provide many key services essential for our wellbeing. These services depend on the temporal stability of plant communities. In turn, stability depends on resistance, which is the capacity of plant communities to withstand exogenous perturbations, and on recovery from their impact. Extreme climatic events disrupt the stability of ecosystems, with unpredictable consequences on ecosystem services. As the intensity and frequency of climatic extremes is expected to rise, understanding how ecosystems respond to extremes is an extremely urgent task. Previous studies exploring the stability-climatic extremes relationship suffer from different limitations: i) lack of in-situ data on vegetation stability to conduct worldwide analyses; ii) scarce focus on the joint influence of taxonomic and functional diversity in affecting stability mechanisms under extreme climate. Moreover, few investigated if extremes cause critical transitions of ecosystem functions. This has prevented understanding of how different ecosystems react to climatic extremes. This project aims at addressing these limitations and improving our fragmented knowledge on the relationship between extremes and stability. Combining cutting-edge analytical tools with extensive, and novel, global databases of time-series of in-situ vegetation and climatic extremes data, the project will analyse the relationship between stability and climatic anomalies, and how it varies in different ecosystems. Results will provide worldwide predictions of ecosystem-specific resistance and recovery to climatic extremes, and new approaches for anticipating critical transitions of ecosystem functions. These outputs will be essential for i) guiding future policies aimed at reducing the impact of extremes on society; ii) mitigating economic loss due to extremes in crucial sectors such as agriculture and food production; iii) providing new methods for investigating how climatic extremes affect ecosystem services.

Keywords: ecosystem stability,resistance and recovery,vegetation,extreme climatic events,time series
Targeting a science-based approach to REd coral reSTORation in a climate change scEnario (RESTORE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,Italy,Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-12-01
End date: 2024-11-30
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 3
Project status: CLOSED

RESTORE deals with the need to restore Corallium rubrum, the Mediterranean red coral, a species of great ecological and commercial value that is of priority for conservation under European legislations because in sharp decline due to overharvesting and climate change effects. RESTORE will pave the path to innovative nature-based restoration approaches harnessing ecological processes thereby underpinning red coral recruitment success to foster its long-term and large-scale recovery and support its resilience to climate changes, overcoming the limitations of the existing restoration methods (e.g., coral transplantation). RESTORE will provide advanced knowledge on positive species interactions - i.e. between coral larvae, coralline algae and their associated microbiome, which are recognized as potential enable factors to enhance coral larvae recruitment. Biofilms of selected isolated bacteria strains will then be produced and tested to be used in coral restoration techniques in both control and natural conditions. The effects of global warming on these positive species interactions, and as a consequence on coral recruitment success, will be experimentally assessed to provide threshold values to be integrated in mathematical modelling approaches that will be applied to predict climate refugee areas for red coral recruits and to spatially guide future restoration projects in the view of diverse climate change scenarios. A marked multidisciplinarity, i.e. in-field and experimental ecology, DNA-based techniques and bioinformatics, mathematical modelling, will boost RESTORE effectiveness through the application of cutting-edge techniques. RESTORE will deliver relevant outcomes to support restoration actions under the EU Biodiversity Strategy and the Green Deal, and will provide an innovative approach potentially transferable and applicable to all Mediterranean corals, thus answering to the call for actions to support the urgent need of restoring the marine ecosystems.

Keywords: coral restoration corallium rubrum larval settlement recruitment coralline algae associated microbiome diversity predictive ecological niche models climate change mediterranean sea