Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
From Femto- to Millisecond and From Ensemble to Single Molecule Photobehavior of Some Nanoconfined Organic Dyes for Solar Cells Improvement (NANOSOL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-06-01
End date: 2011-05-31
Duration (months): 24.0
Total project cost (EUR): 161899.59
EU funding (EUR): 161899.59
Participants: 1
Project status: CLOSED

In this project (NANOSOL), we wish to study the femtosecond to millisecond dynamics of some selected triphenylamine dyes in solutions and confined within MCM-41 mesoporous silica material in absence and in presence of TiO2. The dyes are being proposed as potential candidates for solar energy conversion with an efficiency in classical configuration up to 5.33%. We will interrogate their relaxation dynamics and study the effect of zeolites nanoconfinement on the related and subsequent elementary events from fs to ms regime. Powerful techniques based on ultrafast-laser and single-molecule technologies will be our tools to follow the electronic flow from its birth triggered by a photonic excitation of the dye to its death due a charge recombination. We will then explore for the selected dyes the relationship between the time domain and nature of the zeolites (space domain, nano to micrometer domain).This relationship will be examined at a single molecule and particle level with both time and spectral resolutions. The results will be correlated to their solar-energy conversion efficiency in a classical scheme, and will serve for designing confined systems for a new generation of photovoltaics cells. We believe that the expected results will be of great interest to the scientific community working in nanotechnology (nanoLED’s, nanostwitches, etc) nanomedicine (drug delivery), and environmental science (clean energy), and in particular to those performing dye-sensitized solar cells.

Keywords: physical sciences,femtochemistry,nanoscience,dye-sensitized solar cells,energy,triphenylamines,single molecule,zeolites,dynamics,environmental science.
Trophodynamics of Organic Pollutants Studied by Compound-Specific Isotope Analysis (TOP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2010-03-01
End date: 2012-02-29
Duration (months): 24.0
Total project cost (EUR): 246983.34
EU funding (EUR): 246983.34
Participants: 1
Project status: CLOSED

Endocrine disrupting chemicals (EDCs) and emerging pollutants are of global concern, yet their potential to become biomagnified in the aquatic food webs has not been determined. ‘TOP’ aims to tackle this question by coupling the analyses of pollutants, lipid content, trophic position, and compound-specific stable isotope analyses (CSIA). The objectives are to develop and validate CSIA methods; to refine and apply sampling, extraction and analytical methods to target pollutants in water, sediment and biological samples; to perform field sampling in the UK and China followed by chemical and isotopic analyses; and to predict the transport and fate of the target compounds in the aquatic systems using a multi-compartment (water-plankton-invertebrates-fish) model. Both the host institute and fellow have a proven track record in pollutant fate studies and isotope analysis. TOP therefore supports the collaboration and development of dynamic world-class human resources in the European research system. This proposal consists of a scientific project and scientific and complimentary training. The fellow will receive scientific training to acquire further skills in environmental investigations and data analyses; to design, conduct and report on cutting edge research on emerging pollutants; and to develop novel CSIA approaches. Complementary training will involve the fellow learning and practising transferable skills, e.g. presentation, project management and grant applications, as part of his career development plan. The objectives will be achieved through careful planning and management of the fellowship. The proposed scientific project is timely and appropriate methodology has been established. Novel and state-of-the-art techniques will be used. The supervisors and the fellow have relevant expertises. Regular meetings will be held to ensure progress. The fellow is expected to become an international researcher by the end of the fellowship.

Keywords: water quality monitoring,analytical chemistry,food web,biomagnification,biogeochemistry,aquatic ecology,modelling
Auxiliary factors involved in the post-transcriptional regulation of microRNA expression. (MIRNA BIOGENESIS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-08-03
End date: 2011-08-02
Duration (months): 24.0
Total project cost (EUR): 172434.64
EU funding (EUR): 172434.64
Participants: 1
Project status: CLOSED

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression of complementary mRNAs. They have diverse unique expression patterns and have been implicate in a number of biological processes. It has been shown that in many physiological and pathological conditions individual miRNAs are subjected to post-transcriptional regulation, both at the level of Drosha and/or Dicer processing. The host lab has recently found that hnRNP A1, a protein implicated in many aspects of RNA processing, act as an auxiliary factor for the Drosha-mediated processing of a microRNA precursor, pri-miR-18a. hnRNP A1 binds to the loop of this pri-miRNA and induces a relaxation at the stem creating a more favourable cleavage site for Drosha. Our first objective is to define the functional domains in hnRNP A1 that are required for miR-18a processing. Thus, we will determine whether RNA binding and/or the unwinding activities of hnRNP A1 are required for miR-18a processing. The host lab also found that approximately 14% of all pri-miRNAs have highly conserved loops suggesting that these conserved loops act as landing pads for trans-acting factors influencing miRNA processing. In order to address the question of how widespread is the contribution of hnRNP A1 and other auxiliary factors to pri-miRNA processing I propose to identify other microRNAs that require hnRNP A1 for their processing. Secondly, I plan to identify different auxiliary factors required for the processing of microRNAs containing a conserved terminal loop by affinity pull-down assays followed by peptide mass fingerprint analysis. In summary, experiments carried out in this proposal will reveal the level of complexity for the regulation of microRNA biogenesis and their contribution to physiological states and pathological conditions.

Keywords: health sciences,molecular biology,micrornas,post-transcriptional regulation
Biological agents that actively attack Cultural Heritage stoneworks (BIOATTACH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-06-01
End date: 2011-07-31
Duration (months): 26.0
Total project cost (EUR): 246416.33
EU funding (EUR): 246416.33
Participants: 1
Project status: CLOSED

There is a social and political need to protect and preserve European Cultural Heritage (CH). Outdoor CH stoneworks can be damaged by physical and chemical processes including deterioration processes caused by microorganisms. To effectively protect and maintain long-term conservation of European CH stonework, it is vital to identify the active components of the microbial community that cause the most damage in the biodeterioration processes and define their specific roles. Research in this area has been initially limited to the use of cultivation studies. More recently, in the last decade, research through the application of cultural-independent molecular methods focused on the structural analysis of the microbial community, detection of specific microbial agents, and identification of microorganisms present in the environments where biodeterioration occurs, have been carried out. But only few studies have been performed for the detection of metabolically active components in the biodeterioration processes in prehistoric paintings in caves. Therefore the proposed project is innovative in the CH field, and it focuses on the identification of the active “key players” in the biodeterioration processes and on the understanding of their function and activity. The project will use the most advanced techniques in the microbial molecular ecology including Whole Genome Amplification, 16S rRNA gene, functional gene and RNA analyses to investigate the active components of the microbial community colonising outdoor CH stoneworks. The project has a multidisciplinary approach, based on microbiology, molecular biology, and biogeochemistry linking in-situ with lab-chamber based studies to assess the development and population dynamics of microbial communities on stone. This multidisciplinary approach is essential for a better understanding of the microbial diversity and functional activity in the processes that alter our CH patrimony.

Keywords: cultural heritage,stone artefacts,biodeterioration,environmental molecular microbiology
The neurobiological bases of emotion processing in Primary Insomnia (EMOTIONS IN INSOMNIA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-04-04
End date: 2011-04-03
Duration (months): 24.0
Total project cost (EUR): 160996.91
EU funding (EUR): 160996.91
Participants: 1
Project status: CLOSED

We present an interdisciplinary project which aims to evaluate the neurobiological correlates of emotion processing in primary insomnia. The dimensional approach of emotions (e.g. Bradley, 2000) suggests that they can be described by referring to two dimensions: arousal and valence. In insomnia, while the role of arousal has been widely investigated, few studies have considered the valence. This study aims at evaluating both these dimensions, through a combination of psychological and neurobiological methods. Thirty people with primary insomnia (PI) and thirty good sleepers (GS) will watch neutral, negative and poor sleep-related pictures controlled for arousal and valence. During the task, brain activity will be recorded through functional magnetic resonance image (fMRI). Pictures will be presented within a blocked design. Cortisol levels will be measured to investigate differences between groups due to the quality of sleep. Increased cortisol release should be positively correlated with the severity of the symptoms of insomnia. With respect to the fMRI task, the PI should present an enhanced response to negative stimuli related and unrelated to sleep compared to GS. The innovative aspect of this project is the consideration of the valence dimension, and not only of the arousal dimension, when investigating the physiological correlates of emotions in people with insomnia. The aim is to investigate which neurobiological mechanisms intervene in the relation between the processing of the valence and of the arousal of the stimuli and the quality of sleep. This is expected to deepen the knowledge of insomnia and its relation with psychopathology. Results could have an impact on psychological treatment of insomnia, for example introducing strategies which aim at increasing the patient’s self-regulation of the emotional charge associated with sleep. Bradley (2000). In Cacioppo et al. (Eds.). Handbook of Psychophysiology, 2nd edition, Cambridge University Press.

Keywords: insomnia,emotions,fmri,iaps,cortisol,memory bias
Coupling in Multiferroic and MagnetoElectric Composites (CIMMEC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-09-01
End date: 2011-08-31
Duration (months): 24.0
Total project cost (EUR): 202982.89
EU funding (EUR): 202982.89
Participants: 1
Project status: CLOSED

This proposal has 2 objectives: to carry out a successful scientific project, and to develop and broaden the scientific and transferable skills of the researcher, as a first step in establishing them as an independent researcher. Scientific goal: to make novel composite ceramics with magnetoelectric (ME) / multiferroic (MF) coupling. ME materials provide coupled magnetic and electronic properties. MF materials have direct coupling between their ferroic properties. This can be via a direct (applied field) or indirect (applied voltage/strain) stimulus. ME and MF properties often overlap, but not all ME materials are necessarily MF. There has been an explosion of interest in such materials in recent years, as they have a multitude of potential applications. Most research has looked at single phase MF materials – which unfortunately are inherently very difficult to produce. This project counteracts this problem by investigating ME / MF coupling in two-phase composite ceramic materials, consisting of magnetic and dielectric components. Key scientific objectives: 1 Manufacture of ME / MF composites from hexaferrite and dielectric / ferroelectric / piezoelectric materials 2 Their physical and structural characterisation 3 Their magnetic and (di)electrical characterisation over a range of frequencies and temperatures 4 Their characterisation using Scanning Probe Microscopy (SPM), Magnetic Force Microscopy (MFM) and Piezo Force Microscopy (PFM) 5 The demonstration of ME/MF coupling in such materials Training goals: These will add to the researcher’s skill and knowledge base, and help establish them as an independent researcher: Gain deeper knowledge of ME/MF materials Gain experience of SPM techniques Gain expertise in TEM Training in ME / MF coupling measurements Establish the researcher in the ME/MF community Benefit from mentoring and guidance on grant writing

Keywords: materials engineering,electronic,magnetic and superconductive properties,multiferroic,magnetoelectric coupling,ceramics,composites,scanning probe microscopy,mfm,pfm
The Chemical Code of Cooperation, Conflict and Competition (CHEMDOC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-05-04
End date: 2011-05-03
Duration (months): 24.0
Total project cost (EUR): 214717.73
EU funding (EUR): 214717.73
Participants: 1
Project status: CLOSED

The cooperation displayed by social insects has intrigued evolutionary biologists since Darwin. However, the harmonious appearance of their societies hides many conflicts of interest that exist between individuals in the colony. Social insects are also perpetually engaged in competition over resources such as space, food and mating opportunities. The study of cooperation, conflict and competition in social insects continues to be instrumental in testing evolution and ecology theory. Social insects, particularly ants, mediate these three fundamental biological interactions via pheromones, but the precise mechanisms and evolutionary consequences of these chemical messages are just beginning to be understood. The purpose of the proposed work is to investigate the role of pheromones in cooperation, conflict and competition throughout the lifecycle of an ant colony. I will characterise the pheromones of reproductive ants and determine whether these substances signal an individual’s value as a mating partner (e.g. the quality of a male’s sperm, or a queen’s ability to resist disease) and allow mate choice. This research focuses on the least-studied form of competition in social insects: sexual selection and competition between males. I will also investigate the pheromones produced by queens in developing colonies. Queen pheromones are thought to signal fertility and elicit care from the workers (facilitating cooperation). The same chemicals may also inhibit worker reproduction (a potential conflict), but no previous studies have identified queen pheromones in ants and determined their effect on workers. The proposed research is highly likely to discover the first queen pheromone in any social insect apart from the honey bee. This research is highly multidisciplinary, utilising chemical analysis, electrophysiology, microscopy, immunology, genotyping and behavioural studies, and focuses on evolutionary questions that have received considerable recent attention.

Keywords: entomology,evolutionary biology,animal ethology
Synthesis of novel metallo-receptors for phosphorylated species via dynamic combinatorial chemistry (PHOSPHORECEPTORS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-12-07
End date: 2011-12-06
Duration (months): 24.0
Total project cost (EUR): 172434.64
EU funding (EUR): 172434.64
Participants: 1
Project status: CLOSED

Phosphorylation of proteins and metabolites is an essential mechanism for signal transduction and propagation in the cell and thus of utmost importance for cellular function. In spite of this, there is a lack of synthetic chemical receptors for the detection and separation of phosphoesters that combine selectivity and sensitivity. In this project we aim to develop novel chemical receptors for the efficient recognition of phosphorylated molecules of biological interest. The design of such receptors will be based on metallo-receptors that combine strong binding (through metal-phosphate interactions) with high selectivity (provided by hydrogen-bonding groups and other reversible interactions). In order to assemble the different components of the receptors, we propose to use dynamic combinatorial chemistry (DCC) using the phosphorylated species of interest as templates to “amplify” the best receptors from the virtual dynamic combinatorial library. Once the best receptors are identified using the above methodology and their selectivity and sensitivity are optimised, they will be used for the development of chemical sensors to detect specific phosphorylated species. This will be carried out by incorporating optical labels that change their properties upon binding between receptor and phosphorylated guest. Particular emphasis will be given to the detection of phosphorylated phosphoinositides since they play important roles in cell signalling and regulation and their levels can be correlated to the molecular basis of certain diseases.

Keywords: combinatorial chemistry,environmental chemistry,inorganic chemistry,structural chemistry
BLUE-Enterprise and Trade Statistics (BLUE-ETS)

Framework: FP7 — Cooperation
Programme: Socio-economic sciences and Humanities
Destination: Socio-economic and scientific indicators
Action type: Collaborative project
Countries involved: Italy,Netherlands,Belgium,Slovenia,Italy,Germany,Italy,United Kingdom,Germany,United Kingdom,Norway,Slovakia,Sweden
Call:  (FP7-SSH-2009-A, 2009)
Start date: 2010-04-01
End date: 2013-03-31
Duration (months): 36.0
Total project cost (EUR): 3397538.08
EU funding (EUR): 2666250.0
Participants: 16
Project status: CLOSED

BLUE-ETS is a project on official business statistics and, specifically, on one of EU NSIs key challenges; that is, providing high quality and robust statistical information, for better policy and socio-economic research, and to support the renewed Lisbon Strategy, while: (1) reducing the response burden; (2) simplifying and setting priorities; (3) cutting costs on enterprises, that stem from red-tape, over-regulation and duplications; (4) modernizing and re-engineering the methods for the production of statistics; (5) making data collection less burdensome and providing more information . Along with the principles of subsidiarity and proportionality, BLUE-ETS key aim is to support and contribute to the success of the EU Commission Communications MEETS Decision including Better Regulation for Growth and Jobs in the European Union; Action Programme for Reducing Administrative Burdens in the European Union; and the Reduction of the response burden, simplification and priority setting in the field of Community statistics. Accordingly, BLUE-ETS is expected to contribute to the success of the EU MEETS Decision. Accordingly, the project is tailored on MEETS objectives, especially to “better and more-cost-effective statistics”, by (1) Distilling and spreading “EU-wide” frontier knowledge, stemming from different EU NSIs’ lessons from experience, on how to address common issues, which would allow to share problems, which are akin and involve applying knowledge in both collecting, producing and making available business statistics to governments and the public at large; (2) Learning from each other as to how “chart best” a common strategy and a road to cost-effectively and successfully address the MEETS challenges, without repeating mistakes; (3) Converging towards a coherent, common or compatible, cost-effective and efficient “EU state of the art” or “best practice” in Business Statistics.

Keywords: reduce response burden,cutting costs on enterprises,data collection less burdensome,simplifying,support lisbon strategy,success of meets