Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Judges as Policy Makers? Law under the Lisbon Strategy 2020 (LAW2020)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-08-01
End date: 2016-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

While the focus of public discussion in Europe in recent years has been financial stability, recent attention has shifted to economic growth and competitiveness as a key way out of the crisis. These goals are a central part of the EU's overarching 'Lisbon Strategy'; a policy blue-print to be achieved by 2020. Little attention, however, has been paid to the role of law and Courts in achieving the strategy's goals. This project will address this deficit examining the role of the EU Courts in relation to the Lisbon strategy in 3 key policy fields: health, education and employment. The project will conduct case studies in each field, interviewing judicial and non judicial actors in order to examine both the existing role of EU law in implementing the strategy and the potential interaction between law and the Lisbon Strategy in the future. It will create recommendations on how the interaction between Courts and policy-makers should be structured, drawing on the results of a stakeholder workshop and disseminated through a final report. The report's recommendations and output will be designed to feed into the the Lisbon Strategy's mid-term review in 2015. The applicant will use good existing links to policy-makers and researchers through the host organization - the Hertie School of Governance - to disseminate the research results. Finally, the project can make a lasting impact on the researcher's career integration. As a non-tenured Professor, the research opportunities provided by the grant can give the applicant the opportunity to become better established in an academic system not normally open to international researchers. The project and researcher will furthermore benefit from the inter-disciplinary environment provided by the host, the Hertie School of Governance.

Keywords: eu law,lisbon strategy,relations between judges and policy-makers
Uncovering the mechanism and physiological relevance of myosin-VI-dependent AMPA receptor trafficking in neurons. (MEREMY6)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-08-01
End date: 2016-07-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The proper trafficking of membranes and associated proteins in neurons is crucial for the function of the nervous system. Myosin-VI is an actin-based cytoskeletal motor that promotes membrane trafficking and is suggested to play crucial roles in neurons. Most notably, the myosin affects the intracellular trafficking of AMPA receptors, major neurotransmitter receptors composed of transmembrane protein subunits. In addition, data suggest a potential link between myosin-VI and neurodegenerative diseases such as Alzheimer’s. Here, we want to dissect the molecular mechanism by which myosin-VI acts in AMPA receptor trafficking in neurons. Furthermore, we aim to determine the relevance of myosin-VI-driven AMPA receptor trafficking events for structure, function and plasticity of a well-characterized neuronal circuit, and for behavioral output. To this end, we will focus on Purkinje neurons as a model system. These cerebellar neurons are crucial for the coordination and fine-tuning of movements and for certain forms of motor learning. We will make use of genetically altered mice in combination with approaches such as transfection and live cell microscopy of cultured Purkinje neurons, in vitro genetic rescue experiments, ultra-structural analyses via electron microscopy, electrophysiological methods and behavioral tests. We expect that our study will provide novel, general insights into the mechanism by which myosin-VI functions in membrane trafficking. In particular, the results should shed new light onto the molecular and cellular events that take place in Purkinje neurons and determine output from the cerebellum. Moreover, understanding the mechanism of function of neuronal myosin-VI might impact our view of the pathogenesis of neurodegenerative disease.

Keywords: l302 cell biology and molecular transport mechanisms,l508 behavioral neuroscience,l502 molecular and cellular neuroscience,l311 cell genetics
Reproductive isolation and competitive ability between native and non-native ranges of invasive weeds. (REPROWEED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2016-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Over the last three centuries many species have been dispersed beyond their natural geographic limits by humans, but to our knowledge no reproductive isolation has been demonstrated for such neo-allopatric species. Centaurea solstitialis and C. sulphurea have overlapping distributions in their native and non-native ranges. Our preliminary results show that seed production of Californian inflorescences of both species, treated with pollen from Spanish populations of the same species, was 52% and 44% lower, respectively, than inflorescences pollinated with Californian pollen, suggesting that rapid reproductive isolation may have occurred between native and non-native ranges. Reproductive isolation between Californian and Spanish populations of C. solstitialis was 68% of the reproductive isolation for interspecific hybridization among these three species. Considering the large numbers of neo-allopatric species our results are unlikely to be unique. We already have seeds from Turkey and Georgia, the geographical speciation origin of the species; Spain, the last native range before the colonization of the Americas; Chile, the first American country to be colonized; and California, where the species present the most agressive invasive behavior and higher densities. With these seeds, we plan to obtain an F1 free of maternal effects and to cross-pollinate them to detect levels of reproductive isolation either pre-existing or newly developed in the non-native ranges. We will study the type of incompatibility by means of the study of pollen growth. We also plan to conduct reciprocal transplant experiments in Spain and California to study plant behavior in natural conditions (biomass, pollinator attraction, flower and seed production, herbivory) and to calculate phenotypic plasticity indexes for plants from both regions on both regions. Finally we will study the genetic structure of the populations to try to correlate it with the detected reproductive barriers.

Keywords: v308 population biology - population dynamics - population genetics,v305 ecology,v309 systems evolution - biological adaptation - phylogenetics - systematics
Cellular and viral components in Respiratory Syncytial Virus (RSV) assembly and budding. (RSV BUDDING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2014-08-31
Duration (months): 24.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and pneumonia in infants and the elderly worldwide. Despite that, there is no licensed RSV vaccine and only limited therapeutics exists. RSV primarily infects epithelial cells of the respiratory tract and replicates in the cytoplasm. Viral proteins traffic to the apical cell surface where they assemble into virus filaments and bud. However, the mechanism of virus filament formation and budding is poorly understood, neither is the role of viral filaments versus the budded virus. Budding is an essential step in the life cycle of all enveloped viruses; however, the way by which viruses complete the process and free themselves from the plasma membrane presents a biophysical problem. A great number of viruses were shown to recruit the host’s cellular ESCRT fission pathway. Nevertheless, it has been demonstrated that RSV budding is independent of the ESCRT pathway and therefore studies of RSV have the potential to reveal a new paradigm for membrane fission and virus release. The proposed research focuses on the viral and cellular requirements during RSV assembly and budding. The minimal RSV viral proteins essential for filament formation and budding are fusion (F), matrix (M), nucleoprotein (N), and phosphoprotein (P), therefore all of the above will be used for screening against the human proteome. The screen will eventually lead to cellular protein linking RSV to host machinery utilized for its assembly and release. In parallel, RSV mutants that differ in assembly and budding efficiency compared to WT due to impaired binding to cellular factor will be identified. The new interactions discovered will lead to better understanding the mechanism behind RSV assembly and budding and will shed light on alternative mechanisms of viral release. The ultimate outcome of my research will be generating attenuated RSV for future vaccine development and discovering new targets for antiviral drugs industry.

Keywords: viral budding,rsv,viral-host interactions,rsv vaccine,membrane fission
An open-source software tool for the detailed reproduction of the urban sound environment. (OPENPSTD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-09-01
End date: 2016-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The current research proposal is situated in the field of urban sound propagation, and aims for an open-source software development of the Pseudo-Spectral Time-Domain method (openPSTD). Regardless of our location, we are at all times immersed by a sound environment, which may affect us both positively or negatively. The detailed reproduction of the urban sound environment is essential for analyzing and optimizing it. To date, there is a lack of a detailed 3D acoustic propagation method for this purpose, both due to the computational burden as well as due to the absence of an easy accessible software interface. The openPSTD project aims to provide a full-fledged software tool, accessible for academic research purposes, which enables to efficiently and in detail compute urban sound propagation. To achieve this, the computational method behind the tool will be further developed. Within the project, the software tool will also be implemented and applied to studying both reduction of urban noise as well as to support the positive sound environment, the latter especially directed to train the blind in the auditory perception of the environment through auralization.

Keywords: g304 computational engineering,p110 acoustics,v108 urbanization and urban planning - cities
Implications of copy number variants of the genome in the etiology and progression of colorectal cancer (COLONGEVA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-12-01
End date: 2017-11-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Cancer susceptibility genes involved in Mendelian inherited forms of colorectal cancer (CRC) (e.g., Lynch Syndrome) may account for only 5% of all CRC cases. However, increased cancer risk because of a positive family history may vary from 25 up to 40%, and the genetic basis for this familial aggregation remains largely unknown. Recently, high-resolution genomic strategies have revealed an unprecedented form of structural variation of the genome in the normal population, including copy number variants (CNV) and insertion-deletion polymorphisms (indels), which could predispose and influence on the progression of the disease. Using an array of genomic approaches and next-generation sequencing-based techniques, this proposal aims to discern the role of structural variants of the genome in the susceptibility and tumorigenesis in families with high risk of CRC, and to provide insights into how genome-wide copy number analysis can be used as a strategy to identify novel cancer-predisposing genes and mechanisms. In addition, based on gene expression profiling, we will interrogate the function of genes involved in CNVs and their consequences on gene expression in CRC cells. Furthermore, it is possible that CNV profiles and other genetic variants are associated with clinical conditions. This study will infer the genetic causes and mechanisms that lead to drug resistance in CRC patients. Using whole exome-sequencing, we will determine whether patients with responding and non-responding colorectal tumors to chemoradiotherapy treatment (e.g., 5-fluorouracil) show a different distribution of mutations, in their germline and somatically, and as a consequence which cellular pathways result commonly afflicted. Thus, this project will generate a landscape of genetic alterations associated with predisposition, tumor progression, and treatment response in colorectal cancer, which lately will lead to a better understanding of this disease and bring chances to an individualized medicine

Keywords: l406 cancer and its biological basis,l311 cell genetics,l206 molecular genetics - reverse genetics and rnai,l201 genomics - comparative genomics - functional genomics
New generation of eco-benign multifunctional layered double hydroxide (LDH)-based fire retardant and nanocomposites (ECOFIRE-NANO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-12-01
End date: 2016-11-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Polymeric material products are ubiquitous in various fields in day-to-day life, while a key limitation is most of polymeric materials are flammable. Aim to improve the fire retardancy of polymeric materials, circumvent the drawback of traditional fire retardants (FRs), create novel functionality, in this project, new generation sustainable environment-friendly multifunctional FR and high performance polymer nanocomposites are developed via combination of innovative molecular design, sophisticated chemical synthesis and advanced processing. Layered double hydroxide (LDH), low-cost sustainable environment-friendly nanofiller with good fire retardance, is chosen as the main candidate for offering the fire retardant framework. The multifunctional biobased modifier, β-cyclodextrin(CD)-based (char agent), with high fire retardance, excellent anti-UV property (via combined with chalcone extracted from plant) functional group and strong ionic-exchange capability are designed, synthesized, characterized and used to modify LDH in order to develop multifunctional LDH with excellent fire retardance and anti-UV property. Phytic acid sodium salt derived from plants will be used as co-modifier for LDH in order to provide biobased phosphorus storage (acid source). This combination will form nanoscale biobased intumescent fire retardants in the interlayer of LDH, leading to the fire retardant efficiency is improved significantly compared with traditional organic surfactant (being flammable) modified LDH. To evaluate fire retardant efficiency, anti-UV property and other properties, two typical polymers, epoxy resin and PP, are chosen as polymer models. As novel sustainable multifunctional nanoscale fire retardant, it integrates the present advantages from inorganic-FR, intumescent-FR, nano-FR and reactive-FR in the state-of-the-art and possesses new properties, owning the feathers of sustainability, environmental friendliness, high efficiency, smoke suppression and multifunction.

Keywords: g311 materials engineering,fire retardant,polymer nanocomposites,environmental friendliness,c126 new materials,c121 surface modification,c119 structural properties of materials
Mammalian Chromosome Stability (CHROMSTAB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-10-01
End date: 2016-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Accurate DNA recombination is critical for preventing tumorigenesis and developmental defects. In normal cells, the DNA damage response helps prevent the propagation cells with aberrant chromosome content. It is known that DNA repair often compromised in tumor cells, but much remains to be discovered about its regulation on the molecular level. For instance, how much cell-to-cell or patient-to-patient variation is there in the type and frequency of DNA rearrangements? What puts certain genomic areas at risk for germline rearrangements? We will address these questions by examining in vivo outcomes of recombination-based DNA repair . Since genomic rearrangements can arise during both mitotic and meiotic cell divisions, and many central proteins have conserved roles in mitosis and meiosis, both systems will be studied. Sensitive PCR methods will be used that enable the detection of rare de novo DNA configurations directly from primary (uncultured) cells. We will complement these assays by immuno-FISH microscopy, to investigate both chromosome dynamics and the localization of proteins of interest within the nucleus. These studies will provide insights into how cells repair broken DNA. This fundamental process is essential for the faithful transmission of DNA into daughter cells. In the long term, understanding the underlying molecular mechanisms could pave the way to safer, more personalized cancer therapies.

Keywords: l101 molecular biology and interactions,l103 dna biosynthesis - modification - repair and degradation,l303 cell cycle and division,l406 cancer and its biological basis,l206 molecular genetics
The Development of Cypriot Greek in Individuals with Down Syndrome: Their Morphosyntactic profile, and the effects of Phonetics and Phonology (CG-DS MORPHOSYNTAX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Cyprus
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2012-08-01
End date: 2015-07-31
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

This project investigates the developmental grammar of Cypriot Greek in young individuals with Down Syndrome (CG-DS) and in children with typical language development (CG-TLD) in three specific areas: tense, agreement, and case. Similarities and differences will be compared between the two populations to determine whether DS presents acquisition stages parallel to TLD (but delayed), or whether it presents a fundamentally different development. Previous work has shown that before fully acquiring a language, children with TLD across languages are able to use only certain aspects of grammar at various stages of their language acquisition process. For example, in early development they have been argued to have an under-specified tense feature and use infinitives in environments where tensed verbs are required. A parallel stage was proposed with atypical populations like Specific Language Impairment or DS, who experience the same phenomenon though at an older age. In the only existing study on language abilities in CG-DS, it was shown that adult CG-DS and 7- to 8-year-old CG-TLD frequently perform similarly with regards to tense, agreement, and case with accuracy rates over 95%. The linguistic differences (i.e. consonant & word omissions and production of different inflectional features than those targeted) are not due to a syntactic impairment, as previously suggested for English DS. Instead, differences lie in articulatory restrictions, and use of default features rather than the targeted ones. This study will provide information on the stages of language acquisition in CG-TLD and CG-DS, with specific reference to tense, agreement, and case — the first study of its kind, for CG and beyond. Therefore, this project constitutes innovative research with regard to different stages of (a)typical language development in CG. We further aim to provide sufficient information for therapists for the development of new tools to improve linguistic performance in populations with DS.

Keywords: down syndrome,genetic disorder,tense,agreement,case,(default) inflectional features,phonetic restrictions,morpho-syntax,language acquisition,(a)typical language development,(cypriot)greek