Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecular mechanisms of bacterial motility and type-III secretion in virulence of Salmonella (SALMOVIR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-2012-CIG, 2012)
Start date: 2013-04-01
End date: 2017-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Salmonella are motile, gram-negative, pathogens that infect eukaryotic cells. Outbreaks of salmonellosis are a great economic and health problem worldwide. Many bacteria, like Salmonella, swim through liquid environments by rotating a helical organelle, the flagellum. This sophisticated nanomachine is functionally and structurally related to virulence-associated type-III secretion systems (T3SS) of pathogenic bacteria. The ability to move is of crucial importance for Salmonella virulence and infection of eukaryotic cells. Although the importance of bacterial motility and T3S in virulence of Salmonella is established, a detailed understanding of the expression and molecular interplay between the flagellar and virulence systems during infection is missing. The aim of this research program is to study the mechanisms of bacterial motility during bacteria-host interactions and the molecular function of T3SS using an unique combination of sophisticated bacterial genetics, microscopy, biochemistry and infection biology techniques. Both flagellar motility and the process of T3S are essential for virulence and represent attractive targets for novel anti-microbial agents. Therefore, I will analyze the general importance of flagella and bacterial motility during the Salmonella infection process (Aim 1). In complementary projects, I will focus on the molecular mechanisms of bacterial T3SS like the mechanism of substrate translocation (Aim 2), and screen for compounds that inhibit T3SS (Aim 3). The proposed research program will provide novel and fundamental insights into our understanding of the molecular details of Salmonella virulence. Thereby, the initial events required for the commitment of the bacteria to invasive diseases could become clear. Importantly, this knowledge could be used to design specific inhibitors of bacterial T3SS, which might have the potential for new anti-bacterial agents that are urgently needed at a time when antibiotic resistance is increasing.

Keywords: l607 microbiology,l609 bacteriology,l611 prevention and treatment of infection by pathogens,l809 prokaryotic biology,l101 molecular biology and interactions
Performance standards for wood in construction - delivering customer service life needs (PERFORMWOOD)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Coordination and support actions
Countries involved: United Kingdom,Belgium,Sweden,Germany,Spain,Sweden,France,Czechia
Call:  (FP7-NMP-2012-CSA-6, 2012)
Start date: 2012-09-01
End date: 2014-02-28
Duration (months): 18.0
Total project cost (EUR): 609340.0
EU funding (EUR): 495815.0
Participants: 8
Project status: CLOSED

The project objective is to kick-start the development of new standards to enable the service life specification of wood and wood based materials for construction. This is critical to ensure the future sustainable use of European forests, to ensure customers of wood products get satisfactory and reliable products and to provide supplementary evidence for life cycle evaluations of construction products. This supporting action will utilise the wealth of research data that exists to analyse material test standards (CEN TC38) for their ability to inform on service life and performance. Historical field data will be reanalysed to extract more information on performance and this will be brought alongside service life expectation information gathered from various user groups. It will connect the material resistance with the moisture risk to inform on service life expectations. The task objectives included: Confirming material resistance measure Confirming a moisture risk measure Interpreting field test results with respect to early decay and predicting the service life Reviewing present test protocols (EN 599) – is updating necessary? Proposing improved test methods (mainly field tests) and possible new tests Providing a draft interface standard that considers service life The outcome will begin to focus on delivery of reliable products into the hands of specifiers and users of wood products to ensure the future growth of low carbon construction systems made form wood.

Keywords: service life wood products reliability performance classification tc38 standards moisture risk material durability resistance fungi insects termites
Support Action for Standardisation in Additive Manufactruring (SASAM)

Framework: FP7 — Cooperation
Programme: Nanosciences, Nanotechnologies, Materials and new Production Technologies - NMP
Destination: Integration
Action type: Coordination and support actions
Countries involved: Netherlands,Germany,Norway,Spain,France,France,Belgium,Belgium,Switzerland,United Kingdom,France,Spain,France,Sweden,Netherlands
Call:  (FP7-NMP-2012-CSA-6, 2012)
Start date: 2012-09-01
End date: 2014-02-28
Duration (months): 18.0
Total project cost (EUR): 682654.8
EU funding (EUR): 495000.0
Participants: 18
Project status: CLOSED

SASAM's mission is to drive the growth of AM to efficient and sustainable industrial processes by integrating and coordinating Standardisation activities for Europe by creating and supporting a Standardisation organisation in the field of AM. The Additive Manufacturing (AM) concept is based on additive freeform fabrication technologies for the automated production of complex products. Additive Manufacturing is defined as the direct production of finished goods using additive processes from digital data. A key advantage is that AM eliminates the need for tooling, such as moulds and dies, that can make the introduction of new products prohibitively expensive, both in time and money. This enables the production of forms that have been long considered impossible by conventional series production—in fact, they can be created fast, flexibly, and with fewer machines.

Keywords: additive manufacturing
"Marie Curie Actions in Horizon 2020: regional and international impact" (MC2020)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: MSCA other
Action type: Coordination and support actions
Countries involved: Cyprus
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2012-06-01
End date: 2013-01-31
Duration (months): 8.0
Total project cost (EUR): 201898.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The proposal describes the planning, management and implementation of a two days conference dedicated to Marie Actions in Cyprus, under the Cypriot Presidency of the Council in November 2012. The project is submitted in response to the 2012 Work programme and the aim of the conference is to take stock of the European research training potential, and the importance of international, interdisciplinary, and cross-sectoral cooperation, providing a suitable forum for discussing the future challenges of mobility actions under Horizon 2020.

Keywords: people,horizon 2020,mobility,training,marie curie actions,cy presidency
Changing families and sustainable societies: Policy contexts and diversity over the life course and across generations (FAMILIESANDSOCIETIES)

Framework: FP7 — Cooperation
Programme: Socio-economic sciences and Humanities
Destination: Major trends in society and their implications
Action type: Collaborative project
Countries involved: Sweden,Austria,Germany,Belgium,France,Netherlands,Italy,Italy,Netherlands,United Kingdom,Belgium,Spain,Estonia,Romania,Belgium,Finland,United Kingdom,Switzerland,Italy,Poland,Hungary,United Kingdom,Spain
Call:  (FP7-SSH-2012-1, 2012)
Start date: 2013-02-01
End date: 2017-01-31
Duration (months): 48.0
Total project cost (EUR): 8365754.68
EU funding (EUR): 6495142.31
Participants: 29
Project status: CLOSED

The main objectives of this project are to investigate the diversity of family forms, relationships, and life courses in Europe; to assess the compatibility of existing policies with these changes; and to contribute to evidence-based policy-making. The project will extend our knowledge on how policies promote well-being, inclusion and sustainable societal development among families. Our approach relies on three key premises. First, family life courses are becoming more diverse and complex. Second, individual lives are interdependent, linked within and across generations. Third, social contexts and policies shape individual and family life courses. Building upon these premises we a) explore the growing complexity of family configurations and transitions, b) examine their implications for men, women and children with respect to inequalities in life chances, intergenerational relations and care arrangements, c) investigate how policies address family diversity, d) develop short- and longer-term projections, and e) identify future policy needs. Transversal dimensions that are integrated into the project are gender, culture, socioeconomic resources and life stages. Our approach is multidisciplinary combining a wide range of expertise in social sciences, law and the humanities represented in the consortium of 25 research partners from 15 European countries, old and new member states, and three transnational civil society actors. We will conduct comparative analyses applying advanced quantitative methods to high quality register and survey data, and qualitative studies. The project will also develop a database of the legal content of family forms available in European countries, suitable for comparative analyses. Together with various stakeholders, government agencies, national and local policy-makers, non-governmental organizations and additional members of the scientific community across Europe, we will identify and disseminate innovation and best policy practices.

Keywords: family,society,policies,well-being,life-course,diversity,gender,generations,care,culture,migration,europe,children,change,transitions,inequality,inclusion/exclusion,family relations
Innovative Social and Employment Policies for Inclusive and Resilient Labour Markets in Europe (INSPIRES)

Framework: FP7 — Cooperation
Programme: Socio-economic sciences and Humanities
Destination: Growth, employment and competitiveness in a knowledge society
Action type: Collaborative project
Countries involved: Netherlands,Belgium,United Kingdom,Spain,Hungary,Sweden,United Kingdom,Germany,Netherlands,Greece,Italy,Slovenia,Switzerland
Call:  (FP7-SSH-2012-2, 2012)
Start date: 2013-01-01
End date: 2016-06-30
Duration (months): 42.0
Total project cost (EUR): 3091891.6
EU funding (EUR): 2496062.4
Participants: 15
Project status: CLOSED

The INSPIRES project aims to contribute to resilient and inclusive labour markets in Europe. It comparatively assesses the resilience and inclusiveness of labour markets in European countries, it identifies innovative policies that have contributed to resilience and inclusiveness and it analyzes strategies of policy learning that facilitate the development and transfer of these innovations within and across European nation states. In order to do so, it analyzes in-depth the evolution of labour markets policies, employment policies and social policies. Moreover, it qualitatively and quantitatively assesses the labour market position of vulnerable groups from 2000 onwards. INSPIRES covers eleven countries from all European welfare traditions: Mediterranean, Eastern-European, Anglo-Saxon, Scandinavian and the continental regimes. The consortium consists of a multidisciplinary team of leading European scholars that focus on the labour market, employment issues and social policies. The INSPIRES project aims to accumulate practice-oriented knowledge on the factors that positively and negatively affect resilience and inclusiveness. It seeks to explain differences within and between countries, and within and between the labour market positions of different vulnerable groups on the labour market. INSPIRES intends to isolate the impact of national policies from the structural demographic, social and economic characteristics on labour market resilience. Building upon this analysis, it tries to identify processes of policy learning and innovation that occur in the interactions between policy makers, politicians, non-profit organizations, trade unions, business associations and other stakeholders at the European, national and regional level. The outcomes of INSPIRES contribute to facilitating policy learning and innovation processes across territorial and sectoral boundaries and to the creation of inclusive and resilient labour markets in European countries.

Keywords: innovative policies,inclusive labour markets,policy learning,labour market resilience
Solving High Energy Physics Equations using Monte Carlo Gaming Techniques (HEPGAME)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Fundamental constituents of matter
Countries involved: Netherlands
Call:  (ERC-2012-ADG_20120216, 2012)
Start date: 2013-07-01
End date: 2018-06-30
Duration (months): 60.0
Total project cost (EUR): 1739000.0
EU funding (EUR): 1739000.0
Participants: 1
Project status: CLOSED

The main objective of this proposal is to perform (hitherto unsolved) calculations in Quantum Field Theory (QFT) most of which are urgently needed to make optimal use of upcoming experimental data from the Large Hadron Collider. These specific calculations have been intractable thus far due to their enormous demand of man and computer power. We will make use of the brand new technique of Monte Carlo Tree Search (MCTS) from the fields of Artificial Intelligence (AI) and gaming to resolve this issue and automatize the derivation of formulas and the construction of computer programs. To do so, we will first develop MCTS into a viable QFT tool. Calculations and derivation of the formulas will be done by the (open source) symbolic system FORM developed by the PI. A spinoff of the proposal will be the adaptation and extension of FORM to allow the physics and the AI to work well together. We will make the new technology available for other researchers, enabling a wide range of calculations at a new level of precision.
Development of an artificial information system (XNA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Materials and Synthesis
Countries involved: Belgium,France
Call:  (ERC-2012-ADG_20120216, 2012)
Start date: 2013-04-01
End date: 2018-03-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 2
Project status: CLOSED

Artificial genetic sequences have become an important tool for the development of new therapeutics but may also define a trait of technological innovation. The possibility to synthesize genes, plasmids and chromosomes combined with the possibilities of directed mutagenesis and genetically reprogramming organisms and directing their evolution will become a crucial issue in synthetic biology. The uniformity of genetic alphabets, the universality of the genetic code, the ubiquity of genetic interchanges and the risks of genetic pollution cannot be overlooked. On the other hand, synthetic nucleic acids will become more and more important as potential new drugs. It is proposed to develop an additional type of nucleic acids for the use as information system for the propagation of specific information of non-natural origin. It is the aim of the project to contribute to the development of an artificial genetic system orthogonal to the natural system that can be used as well in synthetic biology as in medicine. Therefore we have to select & develop the appropriate chemical and enzymatic tools. This means (chemically) the selection of unnatural nucleic acids, their precursors and their modification for uptake in bacteria. Specialized polymerases as well as ligases will need to be developed for this purpose. The goal of the project is to design and synthesize a first orthogonal plasmid and new series of aptamers. A first application is the production of new therapeutics. This is a multidisciplinary project involving mainly chemistry and biotechnology. The general project architecture is to explore experimental progress in vivo and in vitro to reach the final assembly of an XNA episome.

Keywords: artificial nucleic acids,nucleotides,nucleotide delivery,selection,aptamers
Mathematics and science for life (MASCIL)

Framework: FP7 — Capacities
Programme: Science in Society
Destination: Strengthening potential, broadening horizons
Action type: Coordination and support actions
Countries involved: Germany,Greece,Netherlands,United Kingdom,Spain,Cyprus,Greece,Germany,Romania,Czechia,Türkiye,Lithuania,Austria,Germany,Bulgaria,Germany,Austria,Germany,Norway,Spain
Call:  (FP7-SCIENCE-IN-SOCIETY-2012-1, 2012)
Start date: 2013-01-01
End date: 2016-12-31
Duration (months): 48.0
Total project cost (EUR): 3776921.22
EU funding (EUR): 3298170.56
Participants: 21
Project status: CLOSED

This project aims to promote a widespread use of inquiry-based science teaching (IBST) in primary and secondary schools. Our major innovation is to connect IBST in school with the world of work making science more meaningful for young European students and motivating their interest in careers in S & T. To this end, we will run training courses in which pre- and in-service teachers will learn about IBST supported by teachers from vocational education, representatives from industry and informal learning. They will develop inquiry tasks in vocational contexts, leading to a large European task repository. Teachers will experience IBST themselves and through iterative cycles of implementation followed by reflection integrate this into their practice. To ensure widespread participation we will use a pyramid model in which we will work with a small number of teachers first each of which will then work with further teachers. Additionally we will develop an innovative interactive e-learning platform. To profit from the international perspective offered by the project teachers will be connected with existing European networks and our own thematic network on IBST through (virtual) meetings, a forum and the task repository. We will adopt a systemic approach to dissemination working with teachers and additionally parents, students, school authorities and policy makers. National and European advisory panels will bring together stakeholders to advise partners throughout the project; dialogue with policy makers will be facilitated by workshops and policy papers. To ensure effectiveness our work will be informed by a detailed analysis of the educational systems in partner nations. We plan to reach more than 65.000 teachers directly and 800.000 teachers indirectly (via stakeholders, media). Throughout, our work will be subject to rigorous evaluation and measures of quality assurance that will be both summative and formative in informing the progress of the project.

Keywords: inquiry-based science teaching,teacher training for pre-service and in-service teachers,systemic dissemination,connecting school and the world of work,international teacher network,policy worksho
Single Pore Engineering for Membrane Development (SPEED)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Products and process engineering
Countries involved: United Kingdom
Call:  (ERC-2012-ADG_20120216, 2012)
Start date: 2013-02-01
End date: 2019-01-31
Duration (months): 72.0
Total project cost (EUR): 2080000.0
EU funding (EUR): 2080000.0
Participants: 1
Project status: CLOSED

Mankind needs to innovate to deliver more efficient, environmentally-friendly and increasingly intensified processes. The development of highly selective, high temperature, inorganic membranes is critical for the introduction of the novel membrane processes that will promote the transition to a low carbon economy and result in cleaner, more efficient and safer chemical conversions. However, high temperature membranes are difficult to study because of problems associated with sealing and determining the relatively low fluxes that are present in most laboratory systems (fluxes are conventionally determined by gas analysis of the permeate stream). Characterisation is difficult because of complex membrane microstructures. I will avoid these problems by adopting an entirely new approach to membrane materials selection and kinetic testing through a pioneering study of permeation in single pores of model membranes. Firstly, model single pore systems will be designed and fabricated; appropriate micro-analytical techniques to follow permeation will be developed. Secondly, these model systems will be used to screen novel combinations of materials for hybrid membranes and to determine kinetics with a degree of control not previously available in this field. Thirdly, I will use our improved understanding of membrane kinetics to guide real membrane design and fabrication. Real membrane performance will be compared to model predictions and I will investigate how the new membranes can impact on process design. If successful, an entirely new approach to membrane science will be developed and demonstrated. New membranes will be developed facilitating the adoption of new processes addressing timely challenges such as the production of high purity hydrogen from low-grade reducing gases, carbon dioxide capture and the removal of oxides of nitrogen from oxygen-containing exhaust streams.

Keywords: membranes,chemical looping,reaction,separation