Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Enabling environments for NCD risk reduction in Ethiopia (ENABLE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Norway,Sweden,Netherlands,United States,Ethiopia,Nigeria,Portugal
Call: Interventions in city environments to reduce risk of non-communicable disease (Global Alliance for Chronic Diseases - GACD) (HORIZON-HLTH-2023-DISEASE-03, 2023)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 4499945.0
EU funding (EUR): 4499945.0
Participants: 12
Project status: SIGNED

To improve the health outcomes of its citizens, Ethiopia must take steps to meet SDG3.4 and decrease the number of premature deaths caused by non-communicable diseases (NCDs). NCD deaths are preventable by tackling their risk factors: unhealthy diets, physical inactivity, and air pollution. These risk factors are becoming increasingly prevalent in urban sites and have their origins in fetal life, and focusing prevention policies on pregnancy can yield significant benefits. Pregnancy is a unique opportunity for lifestyle interventions and antenatal care (ANC) has long been a key strategy for health promotion, disease prevention, early diagnosis, and treatment. The high ANC coverage in urban Ethiopia makes it an ideal program to support access and utilization of quality NCD services for prevention and risk reduction in urban populations. Guided by the immediate need for high-quality implementation research and evaluations in real-word settings to tackle the multisectoral and complex challenges of NCD prevention, we will fill the implementation knowledge gaps by developing, implementing, and assessing the impact of a novel prevention program in four diverse urban sites. We will apply user-centered approaches to adapt effective evidence-based WHO guidelines and implementation strategies with beneficiaries and stakeholders. Our approach for achieving behavior change in pregnant women is twofold: i) thorough assessments of women’s environments and environmental risks, as wider determinants of health; ii) integration of implementation strategies into the National Health Information system of Ethiopia. We will provide real-word evidence for the impact of implementation for behavior change, NCD risk reduction and better maternal and child health. ENABLE will support care providers for continuity and quality of overall healthcare and of NCD care and surveillance, and ultimately strengthen the Ethiopian public health system towards better health for all.

Keywords: environmental health,air pollution,physical activity,nutrition,implementation science,intervention science,lifecourse epidemiology,maternal health
Temporary intraluminal bypass device designed to reduce the rate of diverting stoma and its related complication by at least 70% (CG-100)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01, 2021)
Start date: 2022-06-01
End date: 2025-05-31
Duration (months): 36.0
Total project cost (EUR): 3241875.0
EU funding (EUR): 2269312.0
Participants: 1
Project status: CLOSED

Anastomotic leakage of colon content into the abdominal cavity is the most devastating complication associated with colorectal surgery. Leaks occur in ~22% of cases, leading to increased hospitalization time, higher re-operation rates, increased patient mortality & additional costs. To minimize the risk of a leak, surgeons create a loop of the small bowel which is diverted outside the abdominal wall & connected to a stoma bag to collect patient’s feces for 4-6 months. Diverting stoma significantly diminishes patients’ quality of life, increases cost of care & requires an additional invasive surgery to reverse the stoma. Our novel device, CG-100, is an elastic tubular sheath that is positioned at the anastomosis site during the primary colorectal surgery & creates an internal bypass for all colon content. CG-100 is removed non-surgically 10 days after primary surgery. CG-100 addresses will improve patient quality of life, save ~1350 pa lives & reduce healthcare costs by €4B pa in EU.

Keywords: anastomotic leakage,stoma diversion,colorectal cancer,surgery
Modelling Individual Acoustics for plausible extended realities (MIA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-15
End date: 2027-09-14
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 2
Project status: SIGNED

The growing field of extended reality (XR) has shown how technology can expand the physical world with real-time digital information and interactions through applications spanning from hybrid meetings to assisted hearing. While plausible visual information is easily delivered, when not adapted to each user, generic sound rendering lacks realism, increases cognitive load and limits accessibility. Still, a recent study found that only 97% of analysed applications ignore personalised sound rendering due to its complex acoustic requirements. MIA (Modelling Individual Acoustics for plausible extended realities) aims at individualising audio rendering by developing a widely adoptable solution that leverages advancements in psychoacoustics and explainable artificial intelligence (AI). The proposed research effort will (1) explore and determine requirements across multiple acoustic contexts, (2) prototype an explainable AI model to infer individual audio characteristics, and (3) implement a personalisation procedure based on user actions to guarantee plausibility over specific contexts. The resulting software solution aims to provide a toolkit with minimal hardware requirements to integrate plausible audio in XR applications. MIA will foster open-science practices while exploring protection measures for EU product development, supporting the EU's goals of advancing technological innovation and enhancing digital inclusion, particularly in remote work, education, and hearing assistance technologies. To succeed, MIA integrates the diverse fields of expertise of the researcher on auditory modelling and advanced Bayesian statistics, of the host institution on audio-signal processing and XR applications, and of the secondment host on the development of explainable AI. The researcher will, therefore, have the chance to collaborate with multiple leading experts to expand his expertise and professional networks, supporting his development for an independent career.

Keywords: extended reality,spatial audio,hrtf,probabilistic modelling,user modelling
Deciphering the role of the Mycobacterium tuberculosis exometabolome in mycobacterial virulence (MIMETIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), exhibits an intracellular lifestyle, thriving within host macrophages. This remarkable ability to evade macrophage-mediated killing and withstand the challenges posed by the host environment hinges largely on its exceptional capacity to adapt its metabolism in response to the diverse conditions encountered during infection. Despite progress, our comprehension of Mtb metabolic adjustments in these circumstances remains limited. Preliminary investigations conducted within the host laboratory have unveiled that Mtb releases a multitude of small, soluble molecules into its extracellular milieu when cultured in vitro. These metabolites potentially exert a substantial influence at the host-pathogen interface, subsequently shaping the delicate equilibrium established between the bacterium and its host throughout the course of infection. This proposal is centered on elucidating the role of Mtb exometabolome at host-pathogen interface, with the overarching objectives of (i) advancing our insight into Mtb metabolism and (ii) pinpointing potential novel virulence determinants that might be secreted by the microorganism. The primary phase involves the comprehensive identification and quantification of metabolites present in the bacterial culture medium. This will be achieved through untargeted metabolomics methodologies, primarily utilizing NMR and mass spectrometry. Subsequently, the metabolic pathways governing the biosynthesis and secretion of these metabolites will be characterized. This investigation seeks to unravel the underlying metabolic drivers facilitating the release of these compounds. The culmination of this project involves exploring the impact of a subset of significant metabolites on the physiology of infected macrophages, as well as their role in modulating the immune response. These assessments will encompass a spectrum of in vitro and in vivo strategies.

Keywords: tuberculosis,mycobacterium tuberculosis,microbial metabolism,nmr,ms,macrophage,virulence
Resilience Enhancement for Ticks and Tick-Borne Diseases in Sub-Saharan Africa (ResTick)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Research and Innovation actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Greece,Burkina Faso,Côte d'Ivoire,Benin,Togo,Ethiopia,Uganda,South Africa
Call: New tools, technologies and approaches for vector control in sub-Saharan Africa (HORIZON-JU-GH-EDCTP3-2024-01-two-stage, 2024)
Start date: 2025-06-01
End date: 2028-05-31
Duration (months): 36.0
Total project cost (EUR): 6130555.0
EU funding (EUR): 6130555.0
Participants: 9
Project status: SIGNED

The actions address urgent issues surrounding ticks as disease vectors, focusing on Crimean-Congo Haemorrhagic Fever, within the Sub-Saharan Africa (SSA). Ticks pose significant challenges to ecosystems, economies, and public health, particularly as climate change exacerbates environmental dynamics. Therefore, tackling ticks' impact becomes crucial, including the development of early warning and monitoring systems and the creation of affordable, user-friendly diagnostics. Proactive actions are necessitated as climate-driven shifts are reshaping disease landscape. We seek to enhance resilience against these challenges by establishing a dedicated network focused on understanding tick species, pathogens, and their interactions within the SSA context. Leveraging advanced molecular ecology methodologies, statistics, and cutting-edge technologies, the initiative will establish baseline data for early warning systems and develop point-of-care devices, integrating them into One Health approaches. Additionally, it endeavours to create predictive models for both tick abundance and disease prevalence. ResTick underscores the critical role of interdisciplinary collaboration in addressing these challenges. By bringing together experts from various fields, including molecular biology, ecology, veterinary science, epidemiology and diagnostic assay development, the initiative aims to generate essential tools for managing tick populations and mitigating the spread of tick-borne diseases as integration of scientific findings into practical applications is a key priority for ResTick. Through knowledge dissemination and implementation of innovative prevention strategies, we aim to safeguard public health, support sustainable animal farming, and promote economic vitality in SSA. Through coordinated efforts and cross-border cooperation, ResTick seeks to enhance resilience and fortify societal response to the complex challenges posed by ticks and tick-borne diseases in SSA.

Keywords: monitoring and surveillance tools acaricide management diagnostic test development
Making Sense of Communities of Arms (ARMIES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 1499918.0
EU funding (EUR): 1499918.0
Participants: 1
Project status: SIGNED

This project is an ethnographic study of the everyday deployment of firearms and their societal impact. It examines and compares the various ways firearms produce communities, and focuses on groups that are overlooked in the field of gun studies, such as gun owners associations and hunting clubs. ARMIES hypothesises that these communities are disruptive and transformative ones that exert tremendous power. For an accurate understanding of firearms, these communities must take centre stage. ARMIES spearheads a new research agenda that centralises these communities of arms as material, affective, and political ones that profoundly shape everyday life. It asks: How do firearms produce communities, how do these communities relate to one another, and what is their societal impact? This question will be answered through a comparative and multiscalar analysis of such communities and their members in Brazil, Germany, and South Africa, and global communities, such as international disarmament organisations. Due to the highly embodied, sensational, and affective nature of firearms, ARMIES will use a multisensorial ethnographic approach that comprises ethnographic methods that explicitly target the senses. This approach prioritises embodied experiences, perceptions, and processes of knowledge making. The team of four researchers – the PI and three PhDs – will be steered by an ethos of team ethnography that stimulates collaboration, reflection, and ethnographic imagination. ARMIES is innovative in terms of its theoretical, methodological, and contextual approach to firearms. It will benefit the fields of (political) anthropology, material culture studies, sensorial scholarship, and gun studies. The high gain of this research is threefold: 1) it reconsiders existing theories of human-nonhuman interactions, 2) it creates a novel methodological approach, and 3) it will be ground-breaking science-based evidence for our public understanding of the role of firearms in our society.

Keywords: communities,materiality,ethnography,senses
Open Geometry PET, with 150ps TOF Resolution, for Real Time Molecular Imaging (Open-Imaging)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-04-01
End date: 2023-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Open-IMAGING will develop an innovative Open Imaging System, highly flexible and adaptable to the organ to be examined. The system of the Proof of Concept will consist of two large paddle detectors built with the novel PET (Positron Emission Tomography) technology developed in 4D-PET ERC-ADG. Outstanding (<150ps) Coincidence Time Resolution and placing the detectors closer to the Field of View (FOV) will dramatically increase the sensitivity, allowing high resolution and high contrast images, at lower dose (factor 10) than current commercial scanners. It will open up new venues for real time image-guided interventions (surgery, radiation therapy) and in-vivo tracking of small number of cells. It will also enable performing repeated scans for active surveillance of suspect patients, diminishing the number of false positives, and a safer post-treatment (for instance, chemotherapy) follow-up.
Define a lead candidate for clinical development of a novel T cell therapy (T2Lead)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-09-01
End date: 2025-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

Acute myeloid leukemia (AML) is a disease with a poor prognosis, especially for such patients either failing initial treatment or relapsing thereafter. In AML, specific immune cells such as T cells have been proven to bear curative potential in the context of stem cell transplantation but toxicity and therapy failure are frequent. The use of T cells modified for specificity with chimeric antigen receptors (CAR) has changed the landscape of several blood-borne cancer of the B cell lineage. In AML, however, ongoing development of CAR T cells is associated with severe toxicities, limiting dosing and efficacy because of poor specificity of used targets for AML blasts. In my ERC funded research, I have identified unique AML targets which are not shared with healthy hematopoesis or other relevant healthy organs. Developing CAR against these, I could demonstrate the potential of my strategy. To enable clinical development and exploitation, T2LEAD will identify and develop lead CAR candidates for further translation. T2LEAD will explore the medical and commercial potential of lead CAR and route exploitation towards licensing or spin out or both. T2LEAD will be supported by a strong network of advisors from academia, industry and regulation frame work. Ultimately T2LEAD will help advancing the treatment landscape in AML to the benefit of AML patients.
Lignin integration in bituminous road applications (LIBRA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom,Germany,Austria,France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 4
Project status: SIGNED

LIBRA aims to develop a comprehensive analytical framework to evaluate lignin as a sustainable alternative to bitumen in asphalt pavements. Asphalt, a mixture of mineral aggregates and bitumen, is the most commonly used material in road construction but faces economic and ecological challenges due to its reliance on crude oil. To address this, renewable biomaterials like lignin are being explored. As one of the main components of trees, lignin is highly abundant and produced industrially as a by-product of the paper and pulp industry. Due to the large quantities available, its underutilisation, and chemical similarities to bitumen, it has great potential as an alternative binding material in road applications. However, the chemistry of lignin is very heterogeneous and depends on the biomass source and the processing method, which affects compatibility and durability of asphalt mixtures. To optimise the use of diverse lignin feedstocks, LIBRA will investigate how these chemical variations influence the performance of lignin-modified binders (LMB). In addition, the project will assess the recyclability and the emission of volatile and water-soluble pollutants to determine the direct environmental impact of LMBs. Combining expertise from pavement engineering, biomaterials chemistry, environmental sciences and analytical chemistry, LIBRA will correlate mechanical and chemical properties, examine fundamental (molecular) processes and predict performance and applicability of the LMBs. Techniques such as dynamic shear rheometry, dynamic mechanical analysis, multidimensional nuclear magnetic resonance spectroscopy, and high-resolution mass spectrometry will be employed. The resulting framework will facilitate a sustainable transition to lignin-based asphalt, contributing to more eco-friendly road infrastructure, supporting the EU’s leadership in sustainable construction and addressing global priorities for greener materials and reduced carbon emissions.

Keywords: bio modified binder,asphalt,lignin,bitumen,emission monitoring,mass spectrometry
Pharos: The Greek AI Factory for accelerating AI innovation (Pharos)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: European High Performance Computing
Action type: Research and Innovation actions
Partnership: EUROHPC (JU-JTI)
Countries involved: Greece
Call: Artificial Intelligence Factories (HORIZON-JU-EUROHPC-2025-AI-01-IBA, 2025)
Start date: 2025-04-01
End date: 2028-03-31
Duration (months): 36.0
Total project cost (EUR): 30000000.0
EU funding (EUR): 15000000.0
Participants: 11
Project status: SIGNED

"Pharos: The Greek AI Factory for Accelerating AI Innovation," aims to establish an EU AI Factory in Greece, strategically leveraging the pre-exascale supercomputer "Daedalus" to accelerate AI innovation. This initiative aims to democratize AI by providing resources and tools accessible to various end-users, focusing on startups and SMEs. By focusing on key societal challenges in Health, Culture & Language, and Sustainability, Pharos will drive trustworthy AI solutions that address critical needs. Key features include comprehensive support encompassing upskilling programs, access to high-quality datasets, cutting-edge AI model training capabilities, and dedicated business innovation support. Seamless integration with the powerful Daedalus supercomputer will unlock advanced AI applications, enabling breakthroughs in areas such as predictive analytics for chronic diseases and personalized patient care, cultural heritage and language preservation and promotion, renewable energy and resource management. A strong emphasis on trustworthy AI development ensures that Pharos prioritizes data privacy, security, and ethical considerations throughout the entire AI lifecycle. Furthermore, as an EU AI Factory that will be part of a wider network, Pharos will establish concrete networking and collaboration avenues with other EU initiatives (EDIHs, Data Spaces, NCCs, DeployAI, other AI Factories), contributing to a cross-border AI innovation ecosystem. Pharos represents Greece’s commitment to pioneering in the HPC-powered AI field, with a vision to become a key contributor to ethical and responsible AI use in Europe. By aligning with EuroHPC's strategic goals, Pharos aims to contribute significantly to Europe’s AI landscape, fostering innovation, sustainability, and digital sovereignty.

Keywords: ai factory,daedalus hpc system,pharos,ai models,genai,llms,ml