Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The genetic bases of mycorrhizal root responses to phosphate (MYCROPHOS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-03-01
End date: 2019-02-28
Duration (months): 24.0
Total project cost (EUR): 166156.8
EU funding (EUR): 166156.8
Participants: 1
Project status: CLOSED

Phosphorus is an essential element for all organisms and almost all phosphorus in food chains comes from plants. The majority of land plants acquire it through a highly conserved root symbiosis with Arbuscular Mycorrizal (AM) fungi but a few plant species, among which Arabidopsis, lost this capacity, probably evolving specific tools.Moreover, being phosphate a key regulator of AM symbiosis, gene determinants regulating root traits over low phosphate could also orchestrate the symbiosis establishment. MYCROPHOS aims at understanding the different root adaptive strategies of AM and non-AM plants to low phosphate conditions throughout a Genome Wide Association Study (GWAS) on different root traits with a high-throughput automatic image analysis. Our preliminary data already showed the feasibility of this approach in Lotus japonicus and allowed the identification of several candidate genes that will be characterized, guaranteeing a straightforward implementation of the project. The main objectives of the project will then be: 1) The identification of candidate genes and gene networks governing early root traits in low phosphate conditions through GWAS on 226 Medicago truncatula accessions. 2) The comparison of the genetic determinants and natural allelic diversity regulating root responses to phosphate in three plant species (Lotus, Medicago and Arabidopsis). While facilitating the identification of adaptive strategies of non-AM and AM plants, such multispecies approach will also allow an easier transfer of knowledge of the acquired knowledge. 3) The functional characterization of candidate genes and selected alleles in the three plant species, testing both their role in regulating root traits and mycorrhizas. Overall, this project aims to achieve a pioneering understanding of molecular determinants of plant root responses to phosphate at the interface between Plant Nutrition, Development and Plant-microbe interaction, providing bases for a more sustainable agriculture

Keywords: plant biology,root growth,phosphate nutrition,arbuscular mycorrhizal symbiosis,evolution,lotus japonicus,medicago truncatula,high throughput phenotyping
Bioinspired-polyamidoamine/nanoparticle coatings as high-performing flame retardants for cellulosic fabrics (PANACEA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: TERMINATED

PANACEA project dealt with the design of bioinspired-polyamidoamine/nanoparticle coatings as high-performing flame retardants (FRs) for cellulosic fabrics. The main purpose is to synthesize environment-friendly, non-toxic FRs with performances comparable to those of the best traditional FRs currently used for cellulosic textiles. The overall objective is to study novel coatings based on polyamidoamines (PAAs), a family of synthetic water-soluble biocompatible and biodegradable polymers, bearing in their repeating units the same organic functions present in proteins, that were proven efficient FRs for cotton by the PANACEA supervisor. PAA preparation can be considered green and scalable as obtained by stepwise polyaddition of prim- or sec-amines to bisacrylamides in water, at room temperature and with no added catalysts. Furthermore, the synergism between PAAs and some nanoparticles (NPs) will be studied and exploited for i) improving the FR properties of selected PAAs and ii) reducing the final add-on of the most performing PAAs. PAAs with carboxylic or guanidine groups will be combined with layered double hydroxides and zinc borate nanorods in order to suppress cotton combustion in the most drastic fire scenarios, guaranteeing a low emission of combustion products. In parallel, sulphur-based-PAAs will be combined with graphene and graphene oxide with different sizes and oxidation grades. These coatings will be obtained by a water-based finishing treatment of impregnation/exhaustion and/or Layer-by-Layer assembly of biocompatible PAAs and NPs. Both these approaches are easily scalable, hence adaptable to the needs of pre-industrial production, conclusive objective of PANACEA. To this aim, the durability of such treatments will be objective of the project and achieved by initially grafting of FR PAA bearing reactive vinyl terminals through radical reactions in the presence of thermal or redox initiators, and then interacting with specific synergist NPs.

Keywords: polymer combustion,flame retardancy,polyamidoamines,cotton
DEEP PURPLE: darkening of the Greenland Ice Sheet (DEEP PURPLE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Denmark,United Kingdom
Call: ERC Synergy Grant (ERC-2019-SyG, 2019)
Start date: 2020-01-01
End date: 2025-12-31
Duration (months): 72.0
Total project cost (EUR): 11007344.0
EU funding (EUR): 11007344.0
Participants: 3
Project status: SIGNED

The stability of the Greenland Ice Sheet (GrIS) is a threat to coastal communities worldwide. The PIs have changed our understanding of why it darkens during the melt season, becoming increasingly deep purple due to pigmented ice algal blooms in the ice surface, producing more melt and accelerating the GrIS towards its tipping point, and increasing sea level. The next step jump in our understanding of biological darkening will be provided by DEEP PURPLE, which will establish the factors that control ice algal blooms. These factors are essential for modelling of future melting, which require a process-based understanding of blooming. DEEP PURPLE will quantify the synergies between the biology, chemistry and physics of ice algae micro-niches in rotting, melting ice, and examine the combination of factors which stabilise them. State-of-the-science analytical and observational methods will be employed to characterise the complex mosaic of wet ice habitats, dependent on factors such as the hydrology, nutrient status, particulate content and light fields within these continually evolving ice-water-particulate-microbe systems. We will quantitatively assess why and how the fine light mineral dust particulates contained within the melting ice amplify the growth of ice algae. The particulate content and composition of different layers in the GrIS is dependent on age, and so the algae that the melting ice can support may fundamentally change over time. We look back to understand if the ice biome has changed through the Anthropocene via analyse of fjord sediments. The first draft genome of ice algae will show their key adaptations to glacier surface habitats. DEEP PURPLE looks forward by providing the critical field data sets and conceptual models of ice algal growth that will facilitate the next generation of predictive models of sea level rise due to biologically enhanced melting of the GrIS.

Keywords: greenland ice sheet,bioalbedo,sea level rise
Empowering innovation intermediaries to generate sustainable initiatives to incentivise and accelerate the commercialisation of space innovation (InnORBIT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Coordination and support actions
Countries involved: Germany,Romania,Croatia,Greece,Hungary,Belgium,Bulgaria,Greece
Call: Space hubs (support to start-ups) (H2020-SPACE-2020, 2020)
Start date: 2021-01-01
End date: 2023-07-31
Duration (months): 31.0
Total project cost (EUR): 999937.5
EU funding (EUR): 999937.5
Participants: 10
Project status: SIGNED

InnORBIT will support 50 start-ups and scale-ups to grow and commercialise their space solutions via 20 sustainable and effective initiatives. We focus on SEE and CEE countries with vibrant tech ecosystems and industry verticals with great potential for contributing to the commercialisation of space. We anchor our initiatives to innovation intermediaries well-embedded in their ecosystems, starting with a pivotal space technology and industry association in Romania, an intermediary managing 3 high-tech clusters in Greece and a major digital innovation hub in Croatia. Alongside them we co-develop our solutions: a business support programme to help space entrepreneurs in starting and scaling-up their commercial activities and a capacity building programme for training intermediaries to set up and run local initiatives. We then ?train their trainers? and support them to scout, screen and select the start-ups and scale-ups to participate in the initiatives, emphasising the ones with the most promising potential for application areas (e.g. Galileo, Copernicus) or spinning-in/-out. Well-trained experts will assess their needs and co-define the services required for catalysing their growth in synergy with EU actions. Our service portfolio includes trainings, mentoring, networking and support to access financing and funding opportunities. A monitoring and evaluation framework will allow us to collect ample evidence on the performance of our solutions, improve them and follow up to train and engage additional intermediaries in SEE and CEE. We will support over 20 intermediaries to generate their own local initiatives, openly demonstrating and proving the replication potential of our solutions. We will then pack our solutions along with business models and lessons learnt into a replication guide, enabling other intermediaries to replicate them, while also delivering recommendations for more enabling environments and innovative financial support frames for space innovation.

Keywords: space hubs,space innovation,support initiatives,innovation intermediaries,start ups,scale ups,smes,clusters,digital innovation hubs,business support,accelerators,incubators,hackathons
Chromatin and antigenic variation: The role of histone H1 in gene regulation in African trypanosomes (HISTONEH1TRYP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-04-01
End date: 2014-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Trypanosoma brucei is a unicellular parasite that causes African sleeping sickness, a fatal disease in humans. There is no vaccine and drugs are very scarce and toxic. T. brucei evades the host immune system by periodically changing its dense, uniform coat of variant surface glycoproteins (VSGs), a mechanism knows as antigenic variation. There are hundreds of VSG genes in the genome, but only one is transcriptionally active at a time. I recently observed major structural differences between the chromatin of active and silent VSGs, with the active VSG essentially being devoid of regularly spaced nucleosomes. The factors involved in establishing and maintaining such disparate chromatin conformations remain unknown. In other eukaryotes, much has been learned about the role of canonical histones in gene regulation, but the role of the linker histone H1 remains elusive. Here I propose to characterize histone H1 in T. brucei, specifically investigating its role in VSG regulation. T. brucei has six different H1 isotypes, which can be grouped into three classes based on their N-terminal sequences. Each class will be epitope-tagged so that their nuclear localization can be compared and the genome-wide distribution of each class can be determined. RNA interference will be used to deplete either all or class-specific H1 and the phenotypes will be examined in two ways: by testing the effects on overall chromatin organization and by testing the specific effects on the VSG gene family, including transcriptional regulation, chromatin structure and switching. Finally, bulk or individual H1 proteins will be purified in order to map the post-translational modifications of H1, and amino acid mutagenesis will subsequently be used to test the role(s) of a subset of these modifications. In this study, I hope to participate in the current effort to put histone H1 “back on the map,” while at the same time seeking to understand the role of chromatin in antigenic variation.

Keywords: health sciences,histone h1,histone modifications,chromatin,epigenetics,antigenic variation,gene expression,trypanosoma brucei,variant surface glycoprotein
Analysing Urban Metabolism and Ecological Footprint - A Multi-Scale Approach to Urban Sustainability Accounting and its Policy Implications (ECO-URB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-04-01
End date: 2014-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Today, at the beginning of the 21st century, the majority of the world’s population are living in urban areas, generating significant pressure on the supporting ecosystems. As the available means (i.e., financial and political) to change urban activities, design and lifestyle are limited, it is imperative to identify those sectors and activities with the potential to contribute the most to minimising the urban environmental load and increasing sustainability. Two approaches that are being used to quantify and assess urban sustainability are “urban metabolism” and “ecological footprint analysis”. However, these approaches need to be further developed to better reflect the complexity and unique characteristics of specific urban areas and activities. In the proposed research, I will develop a multi-scale analysis of the urban metabolism and footprint. By combining the above two approaches, I will identify the specific urban activities that contribute the most to urban throughput and will illustrate the gap to sustainability. By uniquely combining top-down (i.e., using secondary data sources) and bottom-up (i.e., surveys and focus groups) data gathering methods, this project will breakdown the studied urban activities into their specific components at the household to the city scales. By combining quantitative and qualitative approaches this research will be able to examine existing and suggested measures (e.g., policies, technologies) and to inform decision makers as to the required directions. This interdisciplinary research will combine data from the social and natural sciences with engineering. It is expected to contribute to the emerging fields of environmental accounting and sustainability sciences as well as to urban and regional planning and public policy. It has the potential to serve as a basis for other urban sustainability studies in Europe and for future collaboration and mutual fertilization with other researchers in the ERA.

Keywords: sustainability,urban metabolism,ecological footprint analysis,environmental accounting,policy,urban and regional planning
Role of TAM signaling in Retinal Homeostasis (TAM IN AMD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Israel
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-06-01
End date: 2014-05-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

Macular and retinal degeneration are common blinding conditions which affect approximately 30% of individuals aged 75 years, and pose considerable socioeconomic burden. Lack of the daily phagocytosis of photoreceptor outer segments (POS) by Retinal Pigment Epithelium (RPE) cells is the basis of such retinal degeneration (RD). This proposal aims to characterize the role of TAM receptor Tyrosine Kinase signaling in maintaining healthy retinal homeostasis. TAM receptors (Tyro3, Axl, Mer) are homeostatic regulators of the Immune, Reproductive and Nervous systems. Mer knockout mice show normal retinal structure at birth; however, at three weeks of age photoreceptors (PRs) begin to undergo apoptotic death, and by 8 weeks the entire PR population is eliminated, causing blindness. Mer mutations in rats and humans, leads to impaired vision and blindness. The two TAM ligands ProS and Gas6 are expressed in the eye. In-vitro experiments have identified Gas6 as the relevant ligand necessary to activate PR phagocytosis, but adult Gas6 KO mice have no PR degeneration, suggesting a role for ProS. To investigate whether ProS is a TAM agonist leading to PR phagocytosis, I developed a unique ProS conditional knockout mouse model. Preliminary results indicate that mice lacking ProS in the eyes show mild RD, suggesting ProS is a functional ligand in-vivo. Deleting both ligands causes severe RD, implying synergism between both ligands. This novel evidence illuminates the mechanism of TAM signaling in-vivo suggesting ligand hetero-dimerization. Using the newly generated mouse model, I propose to characterize the detailed expression pattern of TAM receptors and ligands in the eye, to establish a role for ProS in retinal homeostasis, and to utilize the unique model to better understand the TAM signaling mechanism. A linkage between ligand levels and RD will be tested, and if found, ProS and Gas6 may serve as early biomarkers for retinal degenerative disease.

Keywords: ophthalmology,cell biology,clinical biology,molecular genetics,histology
INCOMING FELLOWSHIPS BIOMEDICINE INSTITUT DE RECERCA VALL D’HEBRON (INCOMED)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-COFUND, 2010)
Start date: 2012-09-01
End date: 2018-02-28
Duration (months): 66.0
Total project cost (EUR): 1389960.0
EU funding (EUR): 555984.0
Participants: 1
Project status: CLOSED

The INCOMED programme promotes 10 postdoctoral fellowships in all areas of biomedicine and clinical medicine at the Research Institute Vall d‘Hebron (IR-HUVH). This is an incoming mobility programme taht promotes training and career development that complies with the concept of individual trans-national mobility. It is addressed to experienced researchers capable of developing a competitive research project and based on the merit of the candidates. INCOMED will publish two calls offering 5 fellowships in each call. Each fellowship will have a duration of two years. Eligible candidates will be invited for interviews and the will freely decide the research topic, destination and research group. Succesful candidates will be asked to sign an employment contract that follows national legislation in Spain and a set of guidelines of good practice at IR-HUVH. INCOMED fellows will have supervised training in the laboratory of their choice and will have career development via a set of activities that includes direct management of the postdoctoral committee at IR-HUVH, active participation at international meetings and mentoring of PhD students. The expected impact of INCOMED in the the European Research Area is the implementation of a tool that allows experienced researchers to obtain professional training and career development in biomedicine and clinical medicine in a leading European University Hospital and Research Centre

Keywords: health sciences,incoming fellows
CRIPTO: Cryptography Research Involving Practical and Theoretical Outlooks (CRIPTO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Computer science and informatics
Countries involved: United Kingdom
Call:  (ERC-2010-AdG_20100224, 2010)
Start date: 2011-10-01
End date: 2016-09-30
Duration (months): 60.0
Total project cost (EUR): 2102041.0
EU funding (EUR): 2102041.0
Participants: 1
Project status: CLOSED

In this project I will investigate four interrelated topics in cryptography from both a theoretical and practical perspective. Each topic is chosen such that it not only provides a testing ground for more general ideas, but it also is grounded in specific examples which can help guide the general principles. Each topic has the potential to make dramatic advances, both on the subject of cryptography itself and how it is used and deployed in the real world. We will be investigating application domains as diverse as cloud computing, electronic voting, protocols for trusted computing and privacy preserving methodologies. Each topic will be tackled however with common tools of provable security, and testing via implementation. In addition we aim to extend the tool box of techniques available to the cryptographer in terms of analysis and development methodologies, by being guided by the above application domains. This research will have a transformative affect on the subject of cryptography and how it is deployed in the real world. We aim to demonstrate that previous “blue-skies” research can have direct practical benefit in applications, by researching in a pipeline of theory-to-practice. In addition we aim to feed back the practical knowledge learned into new theoretical models which capture more realistically the scenarios faced in practice, thus making the pipeline two-way. Finally, the proposal builds on a wealth of knowledge and experience built up at Bristol over the last ten years in these explicit sub-areas. My group at Bristol is not only the best place to execute this ambitious programme of work, but, due to the unique combination of theoretical and practical perspectives we offer, possibly the only place capable of working on these interrelated fronts.

Keywords: cryptography
(BLADES INTO) HIGH TEMPERATURE MATERIAL (TIALBLADE)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Spain,France
Call:  (SP1-JTI-CS-2009-02, 2009)
Start date: 2011-02-01
End date: 2012-08-31
Duration (months): 19.0
Total project cost (EUR): 233105.0
EU funding (EUR): 172476.75
Participants: 2
Project status: CLOSED

The here proposed TiAlBLADE reseach project, deals with one of the specific tasks of the SAGE5 demonstrator which is devoted to the development of an innovative low pressure turbine. A part of the low pressure turbine is composed by blades working in harsh environment. For this specific application, TiAl investment casting is presented as the most efficient as it fulfis both technical and economical requirements. The objective of the project will be to study and improve the different stages of manufacturing TiAl parts, with strong emphasis on the oxidation resistance coating of the materials for a use up to 800ºC, keeping in mind the industrial relevance of the proposed concept.

Keywords: tial blades,investment casting,oxidation resistant coatings