Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Lyric Weapons: Italian Poetry in the Age of Nuclear Anxiety (IPNA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2028-12-31
Duration (months): 36.0
Total project cost (EUR): 396991.08
EU funding (EUR): 396991.08
Participants: 2
Project status: SIGNED

IPNA explores the emergence and evolution of nuclear anxieties in Italian poetry from the Cold War to today (1945–2024), using the lens of environmental humanities. It uniquely positions modern Italian lyric poetry within a transnational study of nuclear anxiety, revealing how poetry reflects and influences environmental concerns globally. By examining the trans-generational expression of nuclear anxiety through poetry, the project aims to uncover new insights into lyric poetry and the relationship between literature and anxiety. Italy's history as a host of American nuclear weapons and home to a prominent Communist Party (1950S-1980S) makes it a key site for the cultural elaboration of 'nuclear anxiety.' This project examines how more than twenty Italian poets articulate responses to existential threats, viewing poetry as a medium to explore the complex interplay between environmental and human precarity. Key poets, including Eugenio Montale, Amelia Rosselli, Andrea Zanzotto, and Antonella Anedda, reflect on nuclear anxieties through their works, highlighting how lyric poetry captures the subtle tensions of this era. This project addresses gaps in the existing literature by focusing on lyric poetry rather than prose or cinema, which have been the primary focus of previous studies. It employs an interdisciplinary approach, combining lyric theory, environmental humanities, world literature, and affective stylistics to explore how poetry serves as a space for grappling with existential threats. The project's transnational perspective contextualizes Italian poetry within broader glocal traditions, offering new insights into the interconnected dimensions of nuclear anxiety and its cultural impacts.

Keywords: modern and contemporary italian poetry lyric theory affect theory environmental humanities world literature
nEanderthal virtual boNe hIstology: deciphering hominin Growth rates, activity and environMental Adaption (ENIGMA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United Kingdom
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-08-21
End date: 2026-02-20
Duration (months): 30.0
Total project cost (EUR): 215937.6
EU funding (EUR): 215937.6
Participants: 3
Project status: SIGNED

A central challenge in the study of the history of humanity is to understand how evolution has shaped who we are today. Neanderthals are our closest relatives in the human evolutionary family tree. Therefore, understanding the differences and similarities between Neanderthals and Anatomically Modern Humans (AMH) is crucial for defining our phylogenetic history. Bone palaeohistology, the study of the microstructure of fossilized tissue, offers scientists a window into the past: Mineralized tissue keeps a record of an individuals' growth and adaptive responses, therefore allowing us to study aspects of life history long after fossilisation. Due to the rapid increase of cutting-edge technology of Virtual Histology, we can image the internal microstructure of bone without inflicting damage to the material. This allows for the high-resolution study of important fossils, including those of early humans. Although of such high potential, bone histology is still a highly understudied field in human anatomical evolution. In this project, I combine advanced X-ray techniques (synchrotron- and lab-based phase-contrast microtomography, synchrotron X-ray fluorescence and infrared spectroscopies) with the investigation of a large sample of skeletal elements from the Krapina Neanderthal collection (dated 130 +/- 10 kya), Croatia, to investigate detailed aspects of their developmental biology. I will do this by 1) Establishing the preservation state of the Neanderthal fossil remains, 2) Examining the speed of maturation of juvenile Neanderthals and 3) Assess the type and intensity of Neanderthal physical activity and environmental adaption. Finally, I will employ the newly acquired knowledge and skills to valorise the 3D modelling of fossil bone microstructure for museum and outreach purposes in commercial settings. The results of ENIGMA will significantly contribute to our understanding of Neanderthal biology, and with that, help us to further define what it means ‘to be human’.

Keywords: bone histology,life history,human evolution,ontogeny,synchrotron radiation,physical activity,adaptation,tomography,science communication
Listening to Silence: The First Blood Test for Risk of Individuals at Prophylactic Time Windows to Develop Type 2 Diabetes Mellitus (PredRegNetworks)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-04-01
End date: 2025-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Type 2 Diabetes Mellitus (T2DM) is a heterogeneous disease, associated with mortality and severe morbidity, and affecting hundreds of millions of people around the globe. Despite some misconception accepted in the public, current models to predict the onset of T2DM have insufficient power, and are generally limited to individuals that already progressed into pre-diabetes states, at which the assignment of disease-preventing treatments is largely ineffective. Clinical-level prediction power (AUC>0.9) among non-diabetic individuals would enable effective pre-emptive strategies, but the way to produce such predictions remined unknown. Based on a new understanding of enhancer-silencer regulatory networks, I have developed a new class of supreme epigenetic biomarkers. Disease-prediction models that built on the basis of these novel understanding and biomarkers, significantly overpower the best currently-available prediction models. Importantly, these pioneering models can identify the people at risk well before the appearance of any clinical symptoms. Strong preliminary evidence signified the potential to develop the first clinical test to identify the risk to develop T2DM and associated diseases among non-pre-diabetic individuals at the required prediction power, and in time to deliver effective disease-preventing treatments. Validation of these results and demonstration of the effectiveness of the new clinical-level test will allows the directions of the effective (though expensive) preventing treatments to the people at risk, thus dramatically improve the way we are dealing with this harmful disease.
New technologies to integrate PLASTIC waste in the Circular Economy (PLASTICE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Processes4Planet (co-programmed)
Countries involved: Spain,Netherlands,Italy,Belgium,France,Austria,Türkiye,Greece
Call: Plastic waste as a circular carbon feedstock for industry (Processes4Planet Partnership) (IA) (HORIZON-CL4-2021-TWIN-TRANSITION-01, 2021)
Start date: 2022-06-01
End date: 2026-11-30
Duration (months): 54.0
Total project cost (EUR): 19869653.66
EU funding (EUR): 15122601.0
Participants: 25
Project status: SIGNED

Nowadays, only 20% of the whole plastic production is recycled due to barriers such as the presence of complex fractions in the waste streams including contaminants or multilayer materials or the mix of plastics with other types of waste that cannot be sorted in a feasible way. This situation implies a high environmental impact when plastic waste is landfilled or incinerated, so new solutions other than mechanical recycling must be developed to significantly increase the amount of plastics being valorized into new feedstocks. PLASTICE was conceived to solve this need by developing a set of new valorization processes that are aligned with the most relevant roadmaps of chemical recycling technologies at European level. Therefore, main efforts will be devoted to the design, development and demonstration under real conditions together with EU waste managers of four valorization technologies: (i) MW-assisted pyrolysis; (ii) hydrothermal liquefaction; (iii) Combined gasification and chemical post-treatment and (iv) Cascade enzymatic hydrolysis. Moreover, PLASTICE overall approach will deploy innovative elements along the whole value chain with the objective of integrating green technologies for the new processes to become sustainable and closing the loop to deliver circular value chains around plastics (including textiles with plastic content). Therefore, PLASTICE works both upstream and downstream the valorization processes, integrating new sorting systems, quality upgrading technologies, digitalization tools and eco-design principles together with new business models linked to each step of the circular value chains. Following this approach, PLASTICE will impact on the amount of landfilled plastics and GHG emissions linked to process operation and fossil fuels-based feedstock. Its replication will be supported by contributing to the development of new standards and regulations, and by creating a community of followers supported by PLASTICE tools and consortium.

Keywords: circular economy plastic valorization digitalization eco design waste sorting waste valorization
UNITED CIRCLES: Networked industrial-urban symbiosis value chain demonstrators for biomaterials, C&DW, circular water loops & WWTPs, driven by Hubs 4 Circularity (United Circles)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Processes4Planet (co-programmed)
Countries involved: Spain,Türkiye,United Kingdom,Hungary,Greece,South Africa,Italy,Germany,Denmark,Switzerland,Belgium,Slovenia,France,Lebanon,Austria
Call: Hubs for circularity for industrialised urban peripheral areas (Processes4Planet partnership) (IA) (HORIZON-CL4-2024-TWIN-TRANSITION-01, 2024)
Start date: 2024-11-01
End date: 2028-10-31
Duration (months): 48.0
Total project cost (EUR): 25349066.25
EU funding (EUR): 19992863.25
Participants: 45
Project status: SIGNED

United Circles project will demonstrate, with 46 partners across 14 countries + 1 international body, three Industrial-Urban Symbiosis value chains, to upcycle of urban Food Waste, urban Wastewater Solids, and urban Construction & Demolition Waste (C&DW). To close urban and industrial water loops to reduce freshwater use in drought prone regions, and integrate energy co-generation technology in upcycling pathways. Made possible by advancing innovative technologies from TRL5 to TRL7 in combined integrated value chains, to enable zero waste cities and a decarbonised Process Industry. The value chains cover collection, sorting, upcycling and production of new upcycled products. To demonstrate how: 1) a demolish building’s C&DW can be transformed into a new 2 storey 3D printed building with upcycled low-carbon cement, cement bonded particle boards, and insulation foam; 2) a waste-water treatment plant can become a resource recovery centre for all materials, water and energy, in an integrated manner. By supplying high quality gas to the local gas grid, by providing upcycled cellulose as industrial feedstock to pulp & paper industries, and by providing clean water and fertilizer for agriculture; 3) food waste in the form of used cooking oil can be upcycled in a first application of 2nd generation biorefinery to create novel fully biodegradable and food waste origin bioplastic products for complete replacement of fossil fuels. The United Circles 3 value chain demonstrators will each be integrated in a Hub 4 Circularity, that will underpin their Industrial-Urban networks governance and evolution, using advanced governance frameworks, feasibility towards financing methodologies, digital tools, social and environmental innovations, and a material and products observatory. The H4C in the proposal will enable business to territory plans, with their regional stakeholder network, that seek to expand the demonstrator integrated technologies to higher TRL levels.

Keywords: industrial urban symbiosis,circular economy,value chains,circular water loops,biomaterials,construction and demolition waste,hubs 4 circularity
"Solar BabySitter"- technology to change solar world (SOLAR BABYSITTER)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Lithuania
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-06-01
End date: 2024-02-29
Duration (months): 9.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Team, led by women CEO Skirmante, is working on disruptive AI based technology for PV plants operation, able to fully replace existing operation models increasing profitability and adapting them to the distributed energy generation system needs. Innovative Energy Intelligence System is in the final stage of development (TRL6). PV has already become recognized worldwide as the cost effective energy source, but it still bears huge potential for further cost reduction contributing to one of the greatest challenges for humanity - eradicating energy poverty. This is achievable through a twofold approach by increasing overall efficiency and improving operation of PV systems. This is where proposed innovative product - SOLAR BABYSITTER is stepping in addressing both cost categories. Team main goal is to successfully and timely enter the market with the developed disruptive technology. This project is an initial step on a pathway to scaling up at accelerated growth scenario, supporting preparation for participation in EIC Accelerator. Team seeks to review and confirm business model, establish solid partnership basis for future business and to develop a sustainable growth strategy. To achieve this target, following project objectives were formulated: 1) PREPARE. To become an investment ready company, mentoring and coaching services are needed to gain skills and knowledge for timely upgrade of SOLAR BABYSITTER. Business model and growth strategy, a series fundraising and other analysis will be prepared for fast market penetration. 2) CONNECT. To establish a strong business partner network. To connect and attract the companies to market validation campaign. Participation and representation in the dedicated networking and pitching events organised by InvestEU, EEN and EIC Woman Leadership Programme, etc. 3) ENGAGE. To engage and attract tech-savvy women to the booming solar sector through campaign “Women Leading Tech” and wide interview-like dissemination events.

Keywords: solar energy,zero net buildings,green society,bipv,digital twin,artificial intelligence,power electronics
Initiation Mechanisms of Lipid-driven Diseases (LIPIDEMIA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

The metabolic syndrome and its several manifestations have currently taken a tremendous toll on many aspects of society. Nonalcoholic fatty liver disease (NAFLD) is considered the liver component of the metabolic syndrome while atherogenic dyslipidaemia, and especially apolipoprotein B (ApoB)-containing lipoproteins, is considered the major causal mechanism in atherosclerosis initiation and progression. By employing novel humanized mouse models that can be rendered acutely dyslipidemic, we have already demonstrated that, at the very onset of dyslipidemia, ApoB-containing lipoproteins interact with immune cells in the liver causing immune and metabolic changes, including ectopic lipid deposition. This opened to the idea that the inflammatory response evoked by acute dyslipidemia plays a pivotal role in the initiation of other important lipid-driven diseases such as NAFLD. Hereafter, we present experiments to elucidate novel mechanisms central to the pathogenesis of NAFLD. We will better define the nature of the innate immune cells that firstly react to a dyslipidemic insult. This will be accomplished by imaging the different hepatic macrophage subsets after transition to dyslipidemia and by examining the physiological changes caused by liver Kupffer cells depletion. Secondly, we will investigate how this initial hepatic response will in turn affect atherosclerosis initiation and progression. We will target atherogenic factors secreted by liver immune cells upon ApoB uptake and inhibit several of them in vivo using neutralizing antibodies. Finally, by employing 2H2O to trace lipids' synthetic rates, we will clarify whether the hepatic lipid accumulation observed in our mice is of endogenous or exogenous sources. This project will yield powerful insights on targetable mechanisms concerning the initiation rather than the end-state of metabolic diseases that are currently endemic to the global population, opening to earlier detection and intervention.

Keywords: dyslipidemia,nafld,lipoproteins,de novo lipogenesis,kupffer cells,atherosclerosis
San Rocco Therapeutics Europe Brings Affordable Gene Therapy for Life-Threatening Rare Diseases (SRTEU4GeneTX)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Sickle Cell Disease (SCD) and transfusion-dependent Thalassemia (TDT) are severe haematological disorders caused by mutations in the beta-globin genes, which are components of haemoglobin molecules. In the EU, more than 80,000 patients are affected by these disorders with direct healthcare costs of €6 billion annually. Gene therapy cures to combat the suffering and shortened life spans are available in the U.S.A. at €2-3 million per patient but are unavailable or have limited availability in the EU. San Rocco Therapeutics Europe S.R.L. (SRT-Europe) is a gene therapy company founded by Patrick Girondi, a father of a thalassemia patient. With three decades developing treatments, SRT-Europe will offer gene therapies for SCD and TDT at an estimated price of €800,000, enabling affordable access to transformative treatments. The lead asset MiNiRoLu, a novel and differentiated lentiviral vector, achieved functional titres of GMP-grade production and enhanced beta-globin expression in clinically relevant human CD34+ cells – 30% superior to the US vectors. MiNiRoLu has EU orphan drug designation and has received Scientific Advice and clinical protocol assistance from the European Medicines Agency (EMA). The TRL6 milestone for GMP vector manufacturing for clinical trial supply has been completed. Other TRL6–aligned preparatory activities for the clinical trials are underway, including the clinical protocol development. The EIC-funded project SRTEU4GeneTX will enable the clinical evaluation of the safety and efficacy of MiNiRoLu in Phase 1b/2 and Phase 2/3 trials and support the submission of a Marketing Authorisation Application to the EMA. In the medium term, a manufacturing site will be built to expand SRT-Europe’s transformative technology to additional rare diseases, creating 50-150 highly skilled jobs in the EU. This grant will secure the first step towards European gene therapy independence.

Keywords: rare diseases,affordable,accessible,curative treatments,scalable platform,gene therapy
Navigating the next normal: Innovative Approaches to Enhancing Youth’s Education-Employment Transitions in Post-COVID-19 Europe (NEXT-UP) (NEXT-UP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Finland,Norway,Portugal,Netherlands,Spain,Italy,Germany,Estonia,Austria
Call: Effective education and labour market transitions of young people (HORIZON-CL2-2024-TRANSFORMATIONS-01, 2024)
Start date: 2025-01-01
End date: 2028-06-30
Duration (months): 42.0
Total project cost (EUR): 2914873.5
EU funding (EUR): 2914873.5
Participants: 11
Project status: SIGNED

NEXT-UP aims to explore and forecast the long-term impacts of the COVID-19 crisis on the transition of youth from school/education to work/employment (YTSTW), focusing on co-creating evidence-informed, future-oriented policies and programmes, alongside innovative stakeholder engagement. The project emphasises inclusivity, particularly supporting disadvantaged groups for equitable job access. To achieve the ambitious goal, our interdisciplinary and multi-profile consortium with prominent academic and NGO partners from nine EU countries enhanced with international advisory board, applies interdisciplinary approaches. Our conceptual lens integrates the Quadruple Helix Model for social innovation with concepts of agency between employability and employer-ability, intersectionality, and policy learning, to enhance theoretical understanding. It focuses on the nexus between youth employment policies, stakeholder perceptions, and youth agency in educational and career choices. Methodologically, we innovatively combine the Living Lab approach, machine learning, psychometric surveys, systematic literature review, longitudinal and focus group interviews, statistical methods, agent-based modelling, and policy design. Triangulating insights from various methods, NEXT-UP fosters a social innovation model to facilitate effective interactions among diverse stakeholders, including policymakers, educators, employers, and youth organisations, to co-create and implement effective strategies for YTSTW. Informed policies and sustained social innovations through NEXT-UP are expected to lead to responsive and resilient educational and employment systems in Europe, innovative educational programmes, and enhanced support for young people entering the workforce. This will significantly impact the formation of social innovation ecosystems to address youth employment challenges in the post-pandemic era and promote social and economic inclusion across Europe.

Keywords: youth transitions,employability,covid 19