Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Environmental contexts during the Iberian Neanderthal Extinction: Insight from the ecology of ungulate preys - EnvINExt (EnvINExt)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

The Middle-Upper Paleolithic (MP-UP) transition is a key period for human evolution, as it corresponds to late Neanderthal’s disappearance and their replacement by Anatomically Modern Humans (AMH), after both species briefly co-occurred. This multifactorial event happened at different spatial and temporal scales across Europe. Climate constitutes a strong driver of species evolution. For Neanderthal, there is no consensus regarding the impact of climate on its disappearance, although it happened during the Marine Isotopic Stage 3, characterized by abrupt and rapid climatic oscillations. In order to track climate changes at the time of the Neanderthal’ demise and the evolutionary success of AMH, ecological proxies filling the gap between local environmental conditions and global climate changes are mandatory. Herbivore teeth are robust traps for physiological, ecological and climatic information and thus mirror past environments. EnvINExt implements three complementary ecological proxies on ungulates preyed by both human species from 10 archeological sites covering the MP-UP transition in North Iberia. Combined Dental Microwear Texture, Enamel Carbon and Oxygen stable Isotope and Molar Mesowear Analyses provide ecological information at three temporal scales, for a global overview of the paleoecology and paleoenvironment of preys and humans. EnvINExt has four objectives: (i) Exploring the ecology of ungulates, key preys for human populations, before, during and after the MP-UP transition, (ii) drawing paleoenvironmental inferences at the scale of the territories exploited by Neanderthals and AMH, (iii) thus, linking global climate changes with local environmental changes and asynchronous disappearances of Neanderthals through north Iberia during the MP-UP transition. Finally, (iv) to confront these results for northern Iberia, a refuge area, with what is obtained in southwestern France (Berlioz’s current postdoctoral work).

Keywords: middle upper paleolithic transition neanderthal extinction paleoenvironments combined ecological proxies
Advanced lasers for quantum technologies (AQLAS)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Malta,France
Call: EIC Transition Open 2023 (HORIZON-EIC-2023-TRANSITION-01, 2023)
Start date: 2024-05-01
End date: 2027-04-30
Duration (months): 36.0
Total project cost (EUR): 2483740.0
EU funding (EUR): 2483740.0
Participants: 4
Project status: SIGNED

Quantum technologies represent one of the fastest emerging high-tech markets. The growth in the production of quantum computers goes hand in hand with the need for more affordable and reliable components of their hardware. In atomic quantum technologies, frequency-stabilised lasers are crucial elements that are used for cooling, manipulating and detecting the qubits. However, most of the systems currently on sale in the market are conceived for a laboratory environment rather than for an industrial production, and the very few turn-key systems that are available are bulky, complex and expensive. In AQLAS, we merge an innovative laser design and a recently developed technology on fiber interferometry to realize a new, affordable and compact laser module for implementing entanglement and high-fidelity qubit read-out in atomic quantum computers. The new laser module overcomes comparable commercial systems in terms of size (4 to 10 times smaller) and cost (2 to 5 times cheaper). In AQLAS, we start from a TRL 4 proof-of-concept that has already demonstrated in the laboratory, and enclose it in a transportable 19’’ rack unit containing all the components, which will represent out Minimum Viable Product (MVP). With the MVP, we will reach TRL 5 by demonstrating the system’s performance in the use case, i.e. a qubit processing at a quantum computer company. After this validation, we will focus on transforming the MVP into an OEM system for industrial production, thus reaching TRL 6. During the project, we will establish a feasible business strategy that will be refined with potential customers and investors. The funding readiness level will be elevated to 6, and we will create a strong IPR strategy with the goal of creating a new startup for which a solid investment case is presented. AQLAS will foster the quantum computing revolution, and contribute in establishing a sustainable quantum computer industry, positioning Europe as a leader in a new frontier technology.

Keywords: single frequency lasers,ecdl,quantum computers,quantum technologies,spectroscopy
Comprehensive Framework for the Future of Water-Energy-Food Nexus and Socio-Environmental Issues in a Transboundary River Basin (FNIT) (FNIT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria,Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-07-01
End date: 2026-06-30
Duration (months): 24.0
Total project cost (EUR): 183600.96
EU funding (EUR): 183600.96
Participants: 2
Project status: SIGNED

This proposal responds to the need for a comprehensive framework to analyze the Water-Energy-Food (WEF) nexus and its impacts on socio-environmental issues. The framework will address such complex issues in the transboundary region of the Euphrates and Tigris Rivers Basin (ETRB), with a focus on climate change, migration, and gender vulnerabilities. The FNIT project will determine the effects of WEF trade-offs on socio-environmental issues by considering various stakeholder viewpoints, generating future scenarios, and assessing long-term risks. This project employs qualitative and quantitative methodologies based on four steps: 1) a diagnostic assessment of the ETRB region’s current situation; 2) scenario planning to generate robust future scenarios; 3) social network analysis to assess socio-environmental impacts; and, 4) integrated nexus governance to achieve systemic integrative outcomes. The FNIT project aims to involve a broad range of stakeholders from the four countries of the ETRB region, e.g., Iran, Iraq, Syria, and Turkey. The participatory approach develops systemic thinking, citizen science, and science diplomacy while minimizing the potential for international conflicts. The results, including the framework, scenarios, and vitalization tools, serve as a fundamental cornerstone and invaluable strategic resource for nexus analysis. These tools, focusing on socio-environmental issues, provide policymakers with a holistic perspective on transboundary matters, helping to mitigate inequality and displacement risks and democratizing policy insights. These results are designed for ease of use with publicly available and open-source data. Additionally, FNIT plays a pivotal role in assisting the European Union in identifying potential socio-environmental risks from the ETBR region that threaten Europe's socio-economic sectors in the future.

Keywords: water energy food nexus transboundary rivers scenario foresight analysis climate change migration gender and climate equity participatory stakeholder engagement,network analysis
NAD+ International Scientist-training (NADIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Finland,Norway,Denmark,Spain,Netherlands,Germany,Switzerland,France
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-11-01
End date: 2026-10-31
Duration (months): 48.0
Total project cost (EUR): 2530832.34
EU funding (EUR): 2530832.34
Participants: 22
Project status: SIGNED

Nicotinamide adenine dinucleotide (NAD+) is a central redox cofactor and the limiting substrate of key metabolic enzymes. The constellation of cellular functions in which NAD+ is involved makes its availability critical for cell survival, and its depletion is a leading factor in a number of diseases in humans, ranging from rare inherited defects to more common multifactorial, often age-related, complications, including type 2 diabetes, neurodegenerative diseases and female infertility. In contrast, NAD+-repletion strategies, such as administration of NAD+ precursors, may be effective in preventing or ameliorating the outcomes of these complications. NADIS partners have made pivotal discoveries in the field of NAD+ biology. First, by discovering novel mechanisms linking NAD+ metabolism to prevalent diseases such as type 2 diabetes, cancer cachexia, Alzheimer’s, Parkinson’s, or rare inherited mitochondrial disease, and to lifespan regulation. Second, by identifying lifestyle, nutritional, and drug interventions that target NAD+ metabolic pathways to combat such diseases and promote healthy aging. Despite these recent advances, there are still major gaps in our current knowledge in regard to (1) how NAD+ homeostasis is regulated at different stages in life, (2) how its imbalance leads to disease at a systemic level and (3) which NAD+ repletion strategy is the most suitable to prevent or treat specific diseases. It is the ambition of the NADIS consortium to fill these gaps by training the new generation of Early Stage Researchers (ESRs) on how to apply state-of-the-art tools to study the interconnection between metabolic cofactors, such as NAD+, and metabolic health at different levels, and to provide them with an interdisciplinary and intersectoral training programme that significantly increases their career perspectives and allow them to become future leaders in the field of translational metabolism.

Keywords: nicotinamide adenine dinucleotide,nad
Quantum Sensing with van der Waals Heterostructures based on hexagonal Boron Nitride (BoNi-SENS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-02-01
End date: 2028-01-31
Duration (months): 60.0
Total project cost (EUR): 2499826.0
EU funding (EUR): 2499826.0
Participants: 1
Project status: SIGNED

The project idea is to implement a new quantum probe based on hexagonal boron nitride (hBN) containing spin defects to study the properties of artificially stacked two-dimensional (2D) materials and devices. The essential building blocks of such van der Waals (vdW) heterostructures are the quantum defects in hBN recently discovered by the PI and his team. These intrinsic lattice defects - negatively charged boron vacancies VB– - can be optically spin-polarized and coherently manipulated, allowing the read-out of quantum information during the coherence time. Our experimental approach is based on coherent manipulation of the spin state using high-frequency pulse protocols, followed by optical readout to explore the adjacent environment, in particular by studying the local lattice strains, pressure, temperature and magnetic fields. The unique feature of hBN is its non-disturbing chemical and crystallographic compatibility with other vdW materials, which gains a new fundamental functionality with the embedded spin centres and allows sensing in heterostructures serving as a boundary itself. Optical readout will be extended by electrical control of spin and charge states, which is an unexplored area and a major step forward in the development of quantum applications of vdW heterostructures. We focus on i) the enhancement of VB– emission and spin resonance contrast by coupling with plasmonic resonators to identify single defects never seen before, ii) the identification of the sources of spin decoherence of these defects, in particular the interaction with other electronic defects and hyperfine-coupled nuclear bath, and their bypassing, and iii) the exploration of semiconducting and magnetic heterostructures and electronic devices based on them. The project aims to establish 2D heterostructures as a flexible platform for new quantum applications based on the optical and electrical control of coherent states and mapping fluctuating external fields on the nanoscale.

Keywords: 2d materials,van der waals heterostructures,color centers,spin coherence,quantum sensing,hexagonal boron nitride,quantum memory
The evolution of host manipulation by bacteriophage. (PHAGECONTROL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Slovenia
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 2255511.0
EU funding (EUR): 2255511.0
Participants: 1
Project status: SIGNED

The idea of parasite manipulation is well known in animal behaviour, with famous examples like the cordyceps ?zombie? fungus of ants. Yet, the most abundant and diverse parasites on earth do not target animals but rather bacteria. They are the bacteriophages, or phages. My hypothesis is that it is in phages that we will find the most important examples of parasite manipulation, examples that will help us both understand and control bacteria, and their impacts. I will focus on the recently-discovered Regulatory Switch (RS) phage, which reversibly excise and reintegrate into the bacterial chromosome to shift the host between different physiological states. I, and others, have shown that RS phages influence a wide variety of bacterial traits including sporulation, biofilm formation, mutation rates or bacteriocin production. However, we do not understand when, how or why these viruses cause such large changes to bacterial behavior. The goal of my project, therefore, is to understand how and why RS phage evolve as a new candidate model of parasite manipulation. Specifcally, I will answer: 1) When and how do RS phages alter host behavior? 2) What is the molecular basis for the effects of RS phage? 3) Why have RS phage evoved to change bacterial behaviours, and is there evidence of counter strategies in their bacterial hosts? I will work with the bacterium Bacillus subtilis, which is strongly affected by RS phage and a model organism, allowing me to employ the very latest molecular methods. My goal is to demonstrate that parasite manipulation is a major factor in the ecology and evolution of bacteria, whereby many bacteria are essentially puppets of their phage masters. Understanding how phage achieve this manipulation also has the potential for broad impacts in an era when the need to find new ways to control bacteria becomes ever greater.

Keywords: prophage,regulatory switch,imaging,transmission,experimental evolution
Advancing Shrimp Health through RNA Interference Technology (ViAqua Therapeutics)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

ViAqua Therapeutics has emerged as a transformative force in aquaculture health management by pioneering an advanced RNA-based technology platform designed to combat diseases that significantly impact global shrimp farming. With annual economic losses exceeding €7B due to diseases like White Spot Syndrome Virus (WSSV), Enterocytozoon hepatopenaei (EHP), and Infectious Myonecrosis Virus (IMNV), ViAqua’s innovative solutions represent a breakthrough in addressing critical challenges in the shrimp industry. ViAqua's core innovation is an oral RNAi technology, delivered through a patented chitosan-based carrier integrated into shrimp feed. This platform triggers targeted immune responses to inhibit viral replication, offering scalable, non-invasive, and environmentally friendly disease management. This approach not only reduces shrimps' mortality rates but also aligns with global sustainability goals by eliminating reliance on antibiotics and chemicals. ViAqua’s solution integrates seamlessly into existing farming practices, allowing farmers to treat large populations with minimal labor. It reduces mortality, stabilizes production, and boosts yields, enhancing economic resilience for smallholder shrimp farmers. This technology improves profitability and creates jobs in biotechnology, manufacturing, and aquaculture, promoting sustainable economic growth. Key milestones, including POC validation in 2018, industrial scalability achieved by 2021, and a successful $8.25M funding round in 2023, have positioned ViAqua to scale operations and launch market-ready solutions. ViAqua aspires to broaden its RNAi platform to other aquaculture species, reinforcing its vision of ensuring sustainable seafood production to meet growing global demands. By addressing critical health challenges, ViAqua is enhancing shrimp farming productivity while contributing to food security, economic resilience, and environmental stewardship on a global scale.

Keywords: biotechnology virology bacteriology bioeconomy biohazards,biological containment,biosafety,biosecurity dna synthesis,modification,repair,recombination,degradation bioprocessing technologies
9-pax battery-electric aircraft for emission-free regional air mobility (Vaeridion Microliner)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

VÆRIDION is a fast-growing deep tech start-up based in Munich, Germany. At VÆRIDION our goal is to develop, build and certify a full electric microliner carrying up to 9 passengers for Short-Haul and Regional Air Mobility by 2030. Our mission to provide an aircraft for Zero emission regional flights is driven by restrictions on CO2 emissions for domestic and short-haul air travel that will stimulate Green Regional Air Mobility. A full electric microliner is cleaner and cheaper to operate than other airplanes in its class, it provides a better travel experience door to door for distances up to 500 km. We offer a new, optimised design based on proven principles, around proven and available technology in electric motors and batteries, that brings lowest risk and shortest route to certification.

Keywords: electric aviation,regional air mobility
In silico trials for pulmonary drug delivery with breakthrough digital twins of the lungs (Twinhale)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Open 2025 (HORIZON-EIC-2025-ACCELERATOR-02, 2025)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 3328750.0
EU funding (EUR): 2330125.0
Participants: 1
Project status: SIGNED

Due to the limitedness of current technologies, the respiratory system has historically been a sort of black box in many aspects of R&D and clinical practice. At Ebenbuild we want to open this black box by building the first accurate, patient-specific simulation models of the lungs, the so-called digital twins of the lungs. In addition to patient data, these are based on first-of-a-kind predictive, physiologically accurate computational models of the respiratory system. By opening the black box for the very first time, our technology holds the potential to become the definitive source of health intelligence for respiratory diseases across a variety of use cases in healthcare and life sciences, from preclinical R&D to point-of-care. This will make Ebenbuild a deep-tech vanguard with a diversified spectrum of scalable products, each with a significant patient benefit and a global revenue potential and with our technological platform at their core. With EIC support we aim at expanding and validating the potential of our technology for provision of Twinhale tool to Biotech, MedTech and Pharma companies. Twinhale supports in-silico trials for pulmonary drug delivery and enables faster development of better inhalable treatments. Achieving this milestone will not only unlock an intriguing business opportunity, but will also be the starting point to further develop and eventually position our platform products along the entire spectrum of the medical value chain, from the inception of novel therapies to their application at the point-of-care.

Keywords: digital twins lungs
Demonstration of the efficacy of a treatment with OPM-101, a RIPK2 inhibitor, in inflammatory bowel disease (DEMETER)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Ulcerative Colitis (UC) affects millions of people in Europe. Current treatments have significant limitations, creating an urgent need for innovation. DEMETER aims to develop OPM-101, an oral small molecule inhibiting RIPK2, a kinase involved in the chronic inflammation causing UC. Phase 1 results in healthy volunteers for OPM-101 are promising, showing excellent safety and an innovative mechanism of action involving immunomodulation rather than immunosuppression. With the support of the EIC Accelerator, we will perform a long-term Toxicity Study, produce GMP batches, design and execute a Phase 2a with 80-100 UC patients in more than 30 European clinical centres. With the success of DEMETER, OPM will be able to demonstrate the efficacy of OPM-101 in UC patients and will allow the licence of the molecule to a pharmaceutical partner. The EIC Accelerator will therefore contribute to OPM’s long term success and will allow OPM to become a leader of a precision medicine cluster in Europe.

Keywords: ibd,immunomodulation,ripk2,ulcerative colitis,opm 101,chronic inflammation,kinase inhibitor,nod2