Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
MYB rearrangements in Adenoid Cystic Carcinoma: protagonists or secondary characters? (SALMYB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-19
End date: 2022-10-18
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Adenoid cystic carcinoma (ACC) is both a rare disease (limited scientific data and professional expertise) and a cancer (complex tumour biology and evasion of conventional therapies). Clinical behaviour differs depending on primary tumour site; salivary gland ACC has poorer prognosis than breast ACC. A majority of ACC harbour MYB rearrangements resulting from chromosomal translocations, with the fusion of MYB and NFIB or MYBL1 and NFIB being the most frequent. The role of translocations in tumourigenesis and whether cells from different primary sites respond differently has not been determined. Identification of specific cell types carrying the translocation and location within the tumour microenvironment might enable development of MYB target-therapies. Our main objective is to elucidate the function of MYB rearrangements in normal salivary and mammary gland cells and the expression of the novel fusion genes in salivary gland and breast ACC. Normal human cells will be transfected with MYB-NFIB and MYBL1-NFIB fusion transcripts and fusion negative, fusion positive and combinations of cells will be compared in terms of cell morphology, differentiation, proliferation, migration and invasion. 3D models, more closely mimicking an in vivo tumour, will be compared to monolayer cultures. In situ localisation of MYB-NFIB and MYBL1-NFIB in salivary gland and breast ACC will be assessed using a novel technology, BaseScope. This ambitious research project will determine the consequences of MYB rearrangements using state-of-the-art methods in molecular and cellular biology, genetic and tissue engineering and pathological anatomy. The project has clear translational potential with social, cultural and economic impacts. Transfer of results to other cancers harbouring MYB rearrangements (eg leukaemia, colon cancer) and our methods in assessing other tumours characterised by chromosomal translocations, eg prostate, colorectal and non-small-cell lung cancer, are further outcomes.

Keywords: chromosomal rearrangements,salivary gland cancer,breast cancer
Advanced theoretical network for modeling light matter interactIon (ATLANTIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Uzbekistan,Argentina,Germany,Russian Federation,Belarus,Bulgaria,France,Czechia,United Kingdom,United Kingdom,Japan
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2018, 2018)
Start date: 2019-03-01
End date: 2024-02-29
Duration (months): 60.0
Total project cost (EUR): 759000.0
EU funding (EUR): 731400.0
Participants: 14
Project status: SIGNED

The ATLANTIC project is aiming at developing a network of advanced theoretical modeling of laser-matter interaction that will foster the development of novel theories by bridging the mathematical descriptions within a consortium of scientific groups who have pioneered these formalisms. These physical models address in details the timescales from the attosecond to the microsecond and the spatial scales from the nanometer to the millimeter, providing accurate but partial predictions of experimental data in a disjoint manner. Connecting the respective formalisms of these communities will enable to address phenomena that remained unexplained so far and to achieve beyond state of art capabilities. First activity will be directly interfacing the simulation results provided by participants using mathematical parametrizations generated from first-principle concepts to the large spatial scale models, enabling to predict the consequences of laser-triggered quantum effects within an efficient simplified formalism. The secondment periods will be used to develop hybrid theories made possible by training research staffs and novel generations to mutually understand and contribute to the development of each others theoretical descriptions. Interdisciplinarity is at the core of this project as it will be bridging several fields of science: ultrafast phenomena, nonlinear optics, condensed matter physics, quantum chemistry, materials engineering, and laser-materials processing. Within the action, novel formalisms will be developed and emerging applications such as harmonic generation, THz wave generation, laser nanostructuring, materials functionalization, complex materials engineering, compound materials science might be further elucidated (described), and young specialists will be trained.

Keywords: laser matter interaction,nanostructure,optical waveguide,nanoparticles,modeling,numerical modeling,theory
GNSS.asia 4 - Leveraging Asia for European GNSS (GNSS.asia 4)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Coordination and support actions
Countries involved: India,Germany,Taiwan, Province of China,China,Belgium,Japan
Call: Awareness Raising and capacity building (H2020-SPACE-EGNSS-2019, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 1112250.01
EU funding (EUR): 1112250.01
Participants: 6
Project status: CLOSED

GNSS.asia is a UNIQUE SUPPORT PLATFORM FOR INTERNATIONAL COOPERATION in GNSS and a proven, effective outreach arm for EGNSS. It serves a COMMUNITY OF INDUSTRIAL PARTNERS, prepares the ground for EGNSS stakeholders’ work in Asia. It is equally recognised by European and Asian industry, institutions and key associations. GNSS.asia is established as a central player in Asia’s GNSS ecosystems, a key ENABLER FOR EUROPE’S GNSS INDUSTRY AND INSTITUTIONS IN ASIA, as an ANTENNA FOR MARKET AND TECHNOLOGY TRENDS and as a broker for opportunities in the MULTI-GNSS HOTSPOT ASIA. Asia is home to half of the global population, and boasts the world’s booming economies, with GROWING USER AND TECHNOLOGY MARKETS. The region features an array of high-tech players which supply GNSS-electronics to the world. The INNOVATION PACE OF ASIA’S TECHNOLOGY SECTOR IS ACCELERATING, with increasing competition for European enterprises in similar market segments. SMES LACK THE IN-HOUSE EXPERTISE AND RESOURCES to systematically target international markets. LARGER COMPANIES ARE NOT ALWAYS COMPETITIVE due to the strong political and institutional dimensions of sales processes. In the run-up to full operations of Galileo GSA/EC can rely on GNSS.asia as FULLY ESTABLISHED PROMOTION MACHINE run by a proven and highly committed team TO CHANNEL GALILEO MESSAGES to relevant actors and multipliers in Asia and Oceania. GNSS.asia4 will sharpen its proven toolbox to leverage its network in Asia for INDUSTRY PARTNERING AND COMPETITIVENESS. The roll-out of a BRAND-NEW INNOVATION PROGRAMME will enable European stakeholders to ENHANCE THEIR UNDERSTANDING OF ASIA’S GNSS TECHNOLOGY MARKETS, while stimulating Europe’s competitiveness and the EMERGENCE OF INNOVATIVE DOWNSTREAM APPLICATIONS. The planned programme of GNSS.asia4 is ENDORSED BY INDUSTRY (GMV, BP, Daimler, NavCert), partner institutions and industrial users including.

Keywords: asia,gnss,matchmaking,partnering,institutions,economic diplomacy,user uptake,adoption,galileo,innovation
Safety of Transport Infrastructure on the TEN-T Network (SAFE-10-T)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Ireland,Ireland,Croatia,Belgium,Switzerland,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Transport infrastructure innovation to increase the transport system safety at modal and intermodal level (including nodes and interchanges) (H2020-MG-2016-Two-Stages, 2016)
Start date: 2017-05-01
End date: 2020-04-30
Duration (months): 36.0
Total project cost (EUR): 2997000.0
EU funding (EUR): 2997000.0
Participants: 14
Project status: CLOSED

The SAFE-10-T project will develop a Safety Framework to ensure high safety performance while allowing longer life-cycles for critical infrastructure across the road, rail and inland waterway modes. Moving from considering critical infrastructure such as bridges, tunnels and earthworks as inert objects to being intelligent (self-learning objects) the SAFE-10-T project will provide a means of virtually eradicating sudden failures. This will be achieved by: • The Safety framework will incorporate remote monitoring data stored in a BIM model that feeds into a decision support framework (DST) that enables decisions to be made automatically with maintenance prioritised for elements exhibiting stress. • A major advance that will be achieved in the project is that the algorithms at an object level and at a network level will incorporate machine learning to train the system to evolve with time using available monitoring data. • A trans-disciplinary approach with experts in Artificial Intelligence and big data management working with owners, engineers with expertise in risk and modelling and sociologists to make decisions. • Our major European infrastructure managers (Rijkswaterstaat for roads and inland waterways and Network Rail) will undertake demonstration projects at critical interchanges and nodes of the TEN-T transport network. The project will achieve significant impact in asset management by: (i) By moving to intelligent objects that communicate their safety condition during extreme events we will provide a means of virtually eradicating sudden catastrophic failure of infrastructure objects. (ii) The project will use Open Linked Data formats to manage all data and inputs from other sources. Mitigation actions can be taken and warnings of the increased risk level can be transmitted to other agencies and the public. (iii) Demonstrate the concept of fully interconnected transport networks on the TEN-T

Keywords: artificial intelligence,risk assessment,structural health monitoring
¡Viable and Alternative Mine Operating System! (VAMOS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Ensuring the sustainable supply of non-energy and non-agricultural raw materials
Action type: Research and Innovation actions
Countries involved: Austria,Austria,Germany,Spain,Belgium,Bosnia and Herzegovina,Slovenia,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,Portugal,Portugal,Portugal,United Kingdom,United Kingdom
Call: Mining of small and complex deposits and alternative mining (H2020-SC5-2014-one-stage, 2014)
Start date: 2015-02-01
End date: 2019-01-31
Duration (months): 48.0
Total project cost (EUR): 9200000.0
EU funding (EUR): 9200000.0
Participants: 21
Project status: CLOSED

Estimates indicate that the value of unexploited European mineral resources at a depth of 500-1,000 metres is ca €100 billion, however, a number of physical, economic, social, environmental and human constraints have as yet limited their exploitation. ¡VAMOS! will provide a new Safe, Clean and Low Visibility Mining Technique and will prove its Economic Viability for extracting currently unreachable mineral deposits, thus encouraging investment and helping to put the EU back on a level playing field in terms of access to strategically important minerals. Deriving from successful deep-sea mining techniques, the ¡VAMOS! mining solution aspires to lead to: Re-opening abandoned mines; Extensions of opencut mines which are limited by stripping ratio, hydrological or geotechnical problems; and opening of new mines in the EU. ¡VAMOS! will design and manufacture innovative automated excavation equipment and environmental impact monitoring tools that will be used to perform field tests in a number of mine sites across Europe with a range of rock hardness and pit morphology. VAMOS will: 1.Develop a prototype underwater, remotely controlled, mining machine with associated launch and recovery equipment 2.Enhance currently available underwater sensing, spatial awareness, navigational and positioning technology 3.Provide an integrated solution for efficient Real-time Monitoring of Environmental Impact 4.Conduct field trials with the prototype equipment in abandoned and inactive mine sites with a range of rock types and at a range of submerged depths 5.Evaluate the productivity and and cost of operation to enable mine-ability and economic reassessment of the EU's mineral resources. 6. Maximize impact and enable the Market Up-Take of the proposed solutions by defining and overcoming the practicalities of the concept, proving the operational feasibility and the economic viability. 7. Contribute to the social acceptance of the new extraction technique via public demonstrations in EU regions.

Keywords: automated mining,low visibility mining,viable inland mining,abandoned mines,flooded mines,opencut mines,real time environmental impact monitoring
Quantifying the effects of interacting nutrient cycles on terrestrial biosphere dynamics and their climate feedbacks QUINCY (QUINCY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-09-01
End date: 2021-08-31
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

Nutrient availability plays a pivotal role in the response of terrestrial ecosystems to increasing atmospheric CO2 and climate change. The global role of nutrients is only poorly understood quantitatively, limiting the predictive understanding of terrestrial biosphere - climate feedbacks. The first generation of global nutrient-carbon cycle models shows strongly diverging estimates of the nutrient effect, resulting from lacking integration of ecosystem observations and fundamental uncertainties in the representation of governing processes. The objective of QUINCY is to clarify the role of the interacting terrestrial nitrogen and phosphorus cycles and their effects on terrestrial C allocation and residence times as well as terrestrial water fluxes. QUINCY will create a novel, predictive framework founded on the principle of resource optimisation, shifting the paradigm of terrestrial biosphere modelling towards an active biological control of matter flows. QUINCY’s main themes are (i) the effects of nutrient availability on plant photosynthesis and respiration, explicitly taking the energy requirement of nutrient acquisition into account, and (ii) the effects of vegetation-soil interactions, namely rhizosphere processes, on plant nutrient availability and soil C turnover. To corroborate these theoretical concepts, QUINCY will synthesise existing and ongoing ecosystem monitoring and manipulation studies. To specifically test emerging hypotheses on the effects of rhizosphere priming on soil C storage and plant nutrition - and to provide currently lacking data for soil-vegetation models - QUINCY will establish a tree mesocosm, elevated CO2 experiment. The novel model concepts will be consistently integrated to form a new general terrestrial biosphere model. For the first time, QUINCY will be able to address the multiway interactions of carbon, nitrogen, phosphorus and water cycles globally in a theoretically well-founded way commensurate with ecosystem observations.

Keywords: nutrient cycles,soil vegetation interaction
Second Generation Beacon for GALILEO/EGNOS EGNSS Search And Rescue applications (HELIOS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Innovation actions
Countries involved: Germany,Belgium,France,France,France,France,United Kingdom
Call: EGNSS applications (H2020-Galileo-2015-1, 2015)
Start date: 2016-03-01
End date: 2020-12-31
Duration (months): 58.0
Total project cost (EUR): 4869656.25
EU funding (EUR): 3471628.5
Participants: 7
Project status: CLOSED

The HELIOS project aims at providing a Second Generation range of Beacons (SGB) and associated antennas designed to operate with the full capability of the new Meosar Cospas/Sarsat (C/S) International Programme (a satellite-based Search And Rescue (SAR) distress alert detection and information distribution system), embedded in the Navigation Satellite Systems as GALILEO. The Search & Rescue community is at a turn of its history. New satellite systems develops the MEOSAR constellation of Cospas-Sarsat system, EGNOS improves significantly the performance of localization introducing new capabilities and new operations impossible before, GALILEO unique differentiation with the RLS added to the performance of the system will contribute to save more lives at sea and on land. The key objectives of the HELIOS project are: 1 - Defining, developing Products (beacons and associated antennas) compatible with EGNSS & SAR services and latest end-users’ requirements. 2 - GALILEO EGNSS & SAR System validation. 3 - Certifications for commercialization. The HELIOS consortium composed of Orolia, Cobham aerospace communications, CNES, SIOEN, Air France, and Airbus, is involved in different relevant international working groups (Cospas-Sarsat, ICAO, EUROCAE), and will ensure that the development phase of the SGB will be in line with the compatibility and interoperability required by the Cospas-Sarsat. Gathering the knowledge of major players recognized in their industry worldwide, the HELIOS partners project will give the vehicle to the European Industry to lead the way for safer, more innovative systems responding to current and evolving market problems.

Keywords: second generation beacons,antennas,return link services,search and rescue,distress,emergency,alert,aviation,maritime,epirb,spread spectrum
Lithic Technology, Social Agency and Cultural Interaction in the Bronze Age Aegean. Percussive stone tools related to stone masonry techniques seen through experimentation and use-wear analysis. (LiTechAe)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-01
End date: 2023-06-30
Duration (months): 36.0
Total project cost (EUR): 281358.72
EU funding (EUR): 281358.72
Participants: 1
Project status: SIGNED

The project proposes for the first time a global approach for the study of stone tools used in masonry in the Bronze Age Aegean. The study focusses on percussive tools used for cutting and dressing stone in Crete, the Cyclades and mainland Greece in the 2nd millennium B.C. This era saw the rise of the first monumental stone architecture in Europe, first in the palaces of Minoan Crete and from the 15th c. BC onwards, in the tombs and citadels of the Mycenaean mainland following trends known since the 3rd millennium BC in Egypt and the Near East . Scholars agree on the use of stone tools along with metal tools in stone masonry. However, in contrast with other contexts (Egypt, Hittite Anatolia), stone tools in question are absent from the archaeological record, and relatively little is known about tools and techniques. Considering that monumental masonry practices require important energy investment and skilled workforce reflecting a complex social organization , understanding related lithic technology is central to an appreciation of how these societies operated . Recent studies also demonstrate that masonry tools and techniques were part of large-scale technological transfers between the Aegean world and the Near East, especially Hittite Anatolia and Egypt . This project will investigate to what degree, in which ways and contexts and why percussive stone tools were used following a multidisciplinary approach: 1) characterization of materials used for tools and masonry, 2) large-scale experimentations testing different types of stone and metal tools on different building materials, 3) multi-scale analysis of use wear traces on both tools and architectural components (archaeological and experimental), 4) comparative ethnoarchaeological study of material issued from key-sites in the Aegean and Anatolia. The research will provide concrete answers to questions of technological order and an important contribution to social agency, cross-craft/cultural interaction issues.

Keywords: experimental archaeology,use wear traces analysis,stone and metal tools,lithic technology,monumental masonry,crafts,networks,materials,bronze age,aegean,anatolia,eastern mediterranean
The assembly and structure of the chloroplast protein import machinery in plants (TOC-maker)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-06-29
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: SIGNED

Plants convert solar energy into chemical energy by the process called photosynthesis in a specialized compartment of the cell known as chloroplasts. Chloroplasts are majorly enriched with nucleus-encoded proteins and to import them, chloroplast outer and inner envelope membranes are equipped with apparatus called the TOC and TIC translocons, respectively. For the TOC apparatus, there are two major configurations, TOC-P and TOC-H, reported so far, which import highly abundant, Photosynthetic and Housekeeping pre-proteins, respectively. TOC-P and TOC-H are multiprotein complexes which must be specifically assembled for proper development and homeostasis of the chloroplast. Due to the dynamic nature of the translocons, component synthesis and assembly must be rapid and tightly coupled, making the process difficult to investigate. Thus, understanding the mechanisms of the assembly process is both challenging and exciting. Biogenesis of TOC complexes is rapidly enhanced during chloroplast development or de-etiolation, and I will exploit this process to investigate the assembly of different TOC configurations, using the model plant Arabidopsis thaliana. For this purpose, transgenic plants expressing epitope-tagged TOC components and cells expressing nascent polypeptides of TOC components with stalled ribosomes will be generated. Proteins transiently interacting with new TOC components, which are predicted to assist integration and assembly of the TOC complex, will be studied by using affinity purification, pulse-chase experiments, and other biochemical techniques, and thus a sequence of assembly events will be elucidated. Although the molecular composition of the TOC protein import machinery has been well studied, the detailed structural organization of TOC complexes has not yet been elucidated. I will address this knowledge gap by analysing affinity-purified TOC complexes from mature chloroplasts at high resolution by cryo-electron microscopy.

Keywords: photosynthesis,chloroplast biogenesis,multi protein complex,protein assembly,protein transport,cryo em