Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The reactive continuum of carbonates (REACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,New Zealand
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 242260.56
EU funding (EUR): 242260.56
Participants: 2
Project status: SIGNED

Calcium carbonates (CaCO3) are a group of minerals with a major impact on Earth's climate, as their formation and dissolution regulate the ocean's capacity to take up CO2 from the atmosphere. While each type of CaCO3 has a reactivity that depends on its structure, composition, and environment, experimental and modelling work generally simplifies CaCO3 as one homogeneous phase. Neglecting the variability in CaCO3 reactivity is especially problematic in coastal systems, which are intimately coupled with the atmosphere, contain a multitude of CaCO3 phases, and where environmental conditions shift rapidly. In REACT, I will introduce and test the concept of a reactive continuum of CaCO3, inspired by models of organic matter degradation. Combining expertise in CaCO3 dynamics, sediment biogeochemistry, and modelling, I will (1) describe the reactive continuum of CaCO3 in a complex mixture of phases through mechanistic laboratory experiments using a novel multi-tracer tool to track the order and rate of dissolution, (2) identify signs of the reactive continuum of CaCO3 in natural sediment environments by combining a thorough geochemical characterization of the sediment with detailed analysis of extracted CaCO3 particles, and (3) determine the effect of human activities on CaCO3 dissolution in coastal sediments by creating a numerical model describing the reactive continuum of CaCO3 and using it to simulate anthropogenic disturbances. REACT will advance our understanding of CaCO3 dynamics, which will be crucial when assessing the seafloor's response to climate change. The project will produce knowledge to support United Nations and European Union sustainability goals, and will provide new research tools for mechanistic studies of CaCO3 dissolution and incorporation into Earth system models. Leading this project will add key skills to my scientific and academic toolbox and prepare me for a career as an innovative, independent and excellence-oriented researcher.

Keywords: sediment,early diagenesis,reaction transport model,stable isotopes,alkalinity,dissolved inorganic carbon,redox
Italian Women Writing Across Languages. Translingual Literature and Female Cosmopolitan Identities (TranslingWOL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,United States,Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-11-01
End date: 2028-10-31
Duration (months): 36.0
Total project cost (EUR): 413379.72
EU funding (EUR): 413379.72
Participants: 3
Project status: SIGNED

TranslingWOL investigates the literary production of Italian women writers involved in long-lasting mobility abroad who express themselves in languages other than Italian, between the 19th and 21st centuries. From a transnational perspective, using an interdisciplinary set of methodological tools (literary theory and criticism, multilingual studies, women’s studies, sociology of literature, archival research, and digital humanities), it provides the first extensive academic study dedicated to Italian translingual women’s literature, which has been excluded from canonisation processes in both Italian and foreign literary histories, and largely overlooked by scholars, on account of its heterodox nature as compared to the traditional identity between language, literature, and nation. Through close-readings of representative case studies, the project shows the existence of common traits within this panorama – at the textual level (motives and forms) and the contextual level (publication and reception) – and leads to the creation of an interpretative framework useful for the study of such production, an alternative to post- and inter- colonial paradigms to which this and analogous translinguistic phenomena are not merely assimilable. Through a distant reading of the overall panorama, all bio-bibliographical traces of each writer are collected and inserted in a specifically designed database, in order to consolidate the importance of the corpus, geo-map the areas of distribution of texts, and highlight the networks between authors. The goal is not only to rediscover a neglected female literary corpus, but also to provide an innovative gendered and multilingual perspective to interrogate literature. In step with EU policies promoting gender equality and multilingualism, TranslingWOL offers a strategic rethinking of the models we generally use to investigate our cultural heritage, which are based on male as well as monolingual schemes, and proposes a complementary reading.

Keywords: literary multilingualism archival research women s literature cosmopolitan identities diaspora studies transnational literature italian heterolingualism self translation studies
Understanding Nanoparticle Transport Mechanisms in the Melanoma Microenvironment via a Tumor-on-a-Chip Approach (MATRIx)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-16
End date: 2028-01-15
Duration (months): 27.0
Total project cost (EUR): 235668.69
EU funding (EUR): 235668.69
Participants: 3
Project status: SIGNED

The MATRIx aims to develop a 3D melanoma tumor model on a chip (ToC) using patient-derived xenograft technology, which mimics the natural tumor microenvironment (TME) to enhance nanoparticle (NP) delivery to the tumor site and enable personalized treatment. In Western countries, melanoma is considered one of the most widespread cancers. Due to its aggressive nature and resistance to drugs, melanoma is the subject of extensive research aimed at creating more effective medications. The clinical translation of nanomedicine for cancer therapy has been hindered by a lack of knowledge regarding the TME, mechanisms of NP uptake and transfer, technical limitations for model implementation, and individual variations in phenotype. ToC modeling is an indispensable tool in cancer research providing a 3D dynamic environment with regulated fluid flow and shear stress, co-culturing, vascularization, easy operation and readout method, and time and cost saving in contrast to other cancer models. in addition, ToC provides high-throughput screening of nanomedicines, susceptibility, and resistance of cancer cells against drugs, allowing personalized therapy for patients with low cost and high reproducibility. Development of NPs based on patient’s melanoma TME response to active targeting NPs is the focus of MATRIx which will be implemented for the first time. My project's key deliverables will consist of identifying key players of TME around NP extravasation and enhancing NP retention at the tumor site. This initiative will aid in the development of more effective personalized cancer treatment strategies and will be of considerable interest to both academic and industrial sectors. MATRIx also fills my knowledge gaps. Following MATRIX conclusion, I will establish myself as a leader in the field of NP development, alongside tumor modeling on chip technology. I will receive advanced training skills to equip myself for conducting independent research and securing a permanent academic role.

Keywords: 3d melanoma tumor model,tumor on chip toc,personalized nanomedicine,patient derived xenograft pdx,nanoparticles transfer on tumor,targeted np on melanomatoc,in vitro tumor modeling
3D templating of ultrasmall metallic nanoparticles by porous columnar liquid crystals (TEMPL3D)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 1
Project status: SIGNED

The emergence of 3D printing technology has revolutionized the field of Liquid Crystal Networks (LCNs), enabling the fabrication of advanced functional materials with unprecedented precision and customization. However, to date, only a few liquid crystal phases (primarily nematic) have been utilized in the 3D printing of structures, thereby limiting the potential of other mesophases in more effectively controlling the anisotropic properties of the final materials. TEMPL3D seeks to overcome this limitation by combining 3D printing technology with the unidirectional order of Columnar Liquid Crystals (CLCs), pioneering a novel 3D patterning method for ultrasmall nanoparticles (USNPs). This approach aims to enhance the intrinsic properties of USNPs along the columnar axis, and potentially introduce entirely new functionalities. By leveraging the unique characteristics of CLCs and the precision of 3D printing, the research intends to develop highly ordered nanoporous polymeric materials with customizable nanopores. These nanopores will act as templates for metallic USNPs, such as superparamagnetic nanoparticles and quantum dots, enhancing or creating new properties. The ultimate goal of TEMPL3D is to develop multifunctional materials with applications in photonics, optoelectronics, soft robotics, and catalysis—surpassing current technological capabilities. This multidisciplinary project is aligned with the MSCA strategy, contributing to Europe’s growth and competitiveness. TEMPL3D also involves a strong exchange of knowledge between the host institution and me. This fellowship will play a key role in advancing my future independent research career in chemistry by offering interdisciplinary training across a wide range of skills, mentorship from leading experts in the field, and the opportunity to establish a new research line that has not yet been explored at the host institution.

Keywords: liquid crystalline networks,nanoparticles,3d printing,columnar liquid crystals,polymeric composites
Packing in Discrete Domains - Geometry and Analysis (PaDiDom)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-07-01
End date: 2029-06-30
Duration (months): 60.0
Total project cost (EUR): 2194125.0
EU funding (EUR): 2194125.0
Participants: 1
Project status: SIGNED

The packing problem associated with a family of sets F seeks a large subfamily of pairwise disjoint members of F. When F comprises the unit balls in d-space, this is the sphere packing problem, which for d = 3 was solved by Hales-Ferguson (Kepler’s conjecture). The cases d = 8, 24 have won Viazovska her Fields Medal. Much of discrete mathematics deals with dense packing problems. The asymptotic rate vs. distance problem, may be the most fundamental open problem about error correcting codes. It seeks the densest Hamming-sphere packing in discrete cubes. A linear code is a linear subspace of F_2n. Such codes are important both in theory and in practice. Here, we seek to maximize dim(C), when every nonzero vector in C has Hamming weight ≥ δn. Despite its mathematical significance and practical importance, the answer remains unknown for all 1/2 > δ > 0, and our best upper bounds on the rate date from the 70’s. Neither do we know if linear codes can be asymptotically as good as general codes. We have made some progress on these key questions of our proposal. The infinite d-regular tree Td is another important metric space where we seek dense sphere packing. It is easy to perfectly pack balls in Td, but not in a periodic manner. Periodic perfect sphere packings in Td coincide with Moore graphs - finite regular graphs of least diameter and largest possible girth (i.e., with no short cycles). Moore graphs were fully characterized in the 70’s, yet we still cannot show that for fixed d ≥ 3 and large r, any periodic packing of r-spheres in Td must have vanishing density. Many important mathematicians, including Erdös, Margulis, and Lubotzky-Phillips-Sarnak sought the largest possible girth of a d-regular n-vertex graph (d fixed, n → ∞). We show how better upper bounds on linear codes yield progress here, whereas bounds on general codes would not do.We use computers as exploratory tools, e.g., to test our new bounds on codes, yet we publish only humanly verifiable proofs.

Keywords: discrete mathematics,coding theory,graph theory,graph spectra,extremal problems,the probabilistic method
2-Dimensional Phase-sensitive ULtrafast SpEctroScopy: unravelling photo-induced reactions by multi-dimensional Raman (2D-PULSES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 1498750.0
EU funding (EUR): 1498750.0
Participants: 1
Project status: SIGNED

We propose the construction and development of a visible/ultraviolet (UV) two-dimensional resonance Raman (2DR) setup with phase-sensitive detection to tackle ultrafast Chemical, Physical and Biological processes. Light-induced reactions cover a broad range of phenomena, from screening of photo-damage in skin upon UV irradiation to carrier relaxation in opto-electronic devices and energy conversion in proteins. Their lowest hierarchical level lies in the interplay of nuclear motion and normal mode couplings, such as funnelling the absorbed energy to the solvent via molecular oscillations in nucleobases, electron-phonon/phonon-phonon couplings in graphene, vibrational cooling in hemeproteins. Nature has intricately coupled vibrational degrees of freedom to facilitate light-energy conversion into synergistic nuclear motions, ruling femtochemistry and femtophysics. Conventional spectroscopic methods project structural information along specific normal coordinates, providing limited insights into these coupled motions. 2DR combines the structural sensitivity inherent to the Raman process with a multi-dimensional scheme, yielding frequency correlation spectra that encode information on the vibronic mode couplings across the entire vibrational manifold. Critically, the development of 2DR and its application to light-driven processes has been hindered by technical and conceptual hurdles. Among them: 1) 2DR realizations have been confined to restricted visible regions, while most biomolecules require spectral tunability and/or UV excitations; 2) vibrational signatures recorded by 2DR can be assigned both to vibrational (anharmonic) mode couplings as well as to (harmonic) high-order Raman transitions. The set up of the proposed novel 2DR approach will circumvent these limitations, establishing an interdisciplinary research team toiling over unsolved problems in which the ultrafast and multidimensional facets play a key role.
Miniaturized Robotic Systems for Autonomous In-Situ Exploration of Critical Raw Materials In Deep Land Deposits (MINOTAUR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Sweden,Denmark,Poland,Portugal,Greece,Belgium
Call: Exploration of critical raw materials in deep land deposits (RIA) (HORIZON-CL4-2024-RESILIENCE-01, 2024)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 4993302.5
EU funding (EUR): 4993302.5
Participants: 8
Project status: SIGNED

MINOTAUR seeks to address the exploration drilling problem from a novel and revolutionary perspective, bringing together geological principles and concepts involved in exploration drilling with modern technologies such as robotics, digital twin technology, and artificial intelligence. Along the way, MINOTAUR proposes novel research directions in allied areas like geophysics, sensing technologies in geology, environmental impact modeling of whole mineral and production systems, numerical modeling of entire mineral systems related to critical raw materials, new drilling techniques, high-resolution sensing technologies, and artificial intelligence with novel data processing tools for a robust and expeditious geological assessment. MINOTAUR takes a fundamentally fresh look at exploration drilling and approaches it as a source seeking and resourcing mapping problem, drawing inspirations from solutions in robotics, but where geology is a central part of the decision, with the outcomes of exploration enhanced through artificial intelligence and digital twin technology.

Keywords: robotics,autonomy,drilling,exploration,geomodelling
A Proactive Approach to the Recovery and Recycling of Photovoltaic Modules (APOLLO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Germany,Türkiye,Norway,Czechia,Switzerland,United Kingdom,Austria,Portugal
Call: Recycling end of life PV modules (HORIZON-CL5-2022-D3-03, 2022)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 6251279.55
EU funding (EUR): 5325755.76
Participants: 18
Project status: SIGNED

Current recycling practices for Photovoltaic (PV) waste modules are unrefined and recover low volume and low value materials. To be economical and sustainable the recycling of PV waste needs to efficiently recover all of the material constituents at a quality suitable for the reuse in new PVs, with minimal impact. APOLLO will create a circular approach to link legacy recycling, future production and future recycling. A pilot line will be demonstrated and used to process an input of 40 tonnes of PV waste which will be recycled, resulting in enough reclaimed materials for 1 tonne of remanufactured silicon and 30 exemplar PV modules. Incoming modules will be streamed by glass composition, enabling batch recovery of high-quality glass, to be used for new solar-grade glass. A novel continuous ‘sonification’ technique, (ultrasonically excited etchant) will rapidly separate silicon, silver, copper and other metals in a sequence along a pipe-based process. Used liquid etchants will be recycled in a closed loop resulting in low waste, small footprint. Further, recovered silicon will be refined to a purity suitable for new PV-grade ingot growth. The objective is to deliver purified silicon with a minimum purity of 99.9999%. Multiple innovations increase the percentage weight recovery from 18% to 93%. APOLLO will prove the suitability of the recycled silicon by growing new ingots, manufacturing solar cells and then new PV modules. 20 PERC-based modules, 10 Tandem modules and 30sqm of single junction perovskite cells will be made. These modules will incorporate new designs, materials and manufacturing methods, and be designed for disassembly and recycling. Blockchain-based Digital Product Passports (DPPs) for PV will be designed and implemented as well as an online marketplace for reused, remanufactured and/or recycled PV components. DPPs provide secure and trustworthy data for the life of the product and aid recycling by supplying material, hazards and history on request.

Keywords: solar photovoltaic,recycling,recyclability,crystalline silicon,blockchain,digital product passports,micro factories,sorting,extraction,refinement,reuse,tracing,circularity
The role of Polycomb Repressive Complex 2 (PRC2) in retrograde signalling (PRCretro)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-06-01
End date: 2028-05-31
Duration (months): 24.0
Total project cost (EUR): 207758.16
EU funding (EUR): 207758.16
Participants: 1
Project status: SIGNED

Polycomb Repressive Complex 2 (PRC2), as one of the most well-described Polycomb group (PcG) complexes, catalyzes the trimethylation of histone H3 lysine 27 (H3K27me3) and represses transcription of target genes. It is a central regulator in multiple developmental processes and conserved across diverse eukaryotes. Recent results from the host lab suggested novel roles of A. thaliana PRC2 in retrograde signalling. To study retrograde signalling, chloroplast translation inhibitor lincomycin was revealed to affect plastid-encoded photosynthetic genes (PhAPGs) and nuclear-encoded photosynthetic genes (PhANGs). The mechanism of PhANGs repression depends on the optimal function of GENOMES-UNCOUPLED (GUN) genes and loss-of-function mutant gun1 fails to repress the PhANGs in response to lincomycin. Interestingly, I recently found that root growth of single mutants of clf-29, swn-3, double mutants of clf-29gun1-1, and swn-3gun1-1 is insensitive to lincomycin, and the mutants phenocopy gun1 upon lincomycin. However, how PRC2 involved in retrograde signalling remains unknown. Therefore, PRCretro project aims to understand the fundamental aspect of PRC2 in retrograde signalling by three WPs. PRCretro combines the applicant’s expertise in root-shoot communication and physiological studies with the host lab's expertise in developmental epigenetics. Together, PRCretro project will provide the first knowledge on epigenetic contribution and root-shoot communication to retrograde signalling. It will also establish the fundamentals for studying retrograde signalling and PRC2 in moss, laying the foundation for evolution studies. The research results of PRCretro project will be disseminated to the scientific community by submission of high-impact scientific articles and oral presentations.

Keywords: epigenetics,prc2,retrograde signalling,transcriptomics,root shoot communication,h3k27me3