Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mapping the Cosmic Gas Supply with ALMA (Cosmic_Gas)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-11-01
End date: 2024-10-31
Duration (months): 84.0
Total project cost (EUR): 2457500.0
EU funding (EUR): 2457500.0
Participants: 1
Project status: SIGNED

The molecular gas phase is the material in galaxies out of which stars form. As such, it is the quantity that controls the star formation rate of a galaxy, thereby the overall stellar mass build-up, and ultimately galaxy evolution through cosmic times. In contrast to studies of the stellar mass and star formation, characterizing this fuel supply in galaxies as a function of cosmic epoch is still in its infancy. The ALMA facility now redefines our ability to map out the cosmic cold gas supply, essentially unknown at present. This ERC proposal is based on extensive approved observational ALMA programs, led by the PI: ASPECS is the first-ever approved ALMA large (150h) program, aimed at providing a comprehensive view of the baryon cycle from gas to stars over cosmic time. ASPECS will provide 3D molecular scans in two ALMA bands of the Hubble Ultra Deep Field -- the iconic cosmological deep field. A second focus is the detailed characterization of the molecular gas content at z>6 in host galaxies of the most distant quasars via ALMA. This will assess the role of cold gas in the build-up of the first (t_Universe < 1 Gyr) massive cosmic structures in the Universe, again through significant approved ALMA programs led by the PI’s group. The studies outlined here will fully capitalize on the unparalleled capabilities of ALMA to map out the cosmic gas supply through cosmic history, and will provide crucial insights to define observational strategies for JWST (the PI is member of the European JWST/MIRI science team). Through his track record, past achievements in the field of galaxy evolution studies, and through the available proprietary data, the PI is uniquely positioned to lead this ambitious program, which will define the global state-of-the-art in cosmological galaxy evolution through high-redshift ISM studies.

Keywords: high redshift quasars,cosmic gas supply
Determination of transcription factor cooperativity driving expression from the inactive X chromosome (TAXi-ch)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-03-01
End date: 2022-08-29
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

Transcription factor (TF) cooperativity controls gene expression and is essential to establish transcriptional programs during development. One of the hallmarks of development in female mammals is the inactivation of one of the two X chromosomes to achieve dosage compensation of X-linked genes. Although the inactive X (Xi) chromosome is a heterochromatin environment, a small fraction of genes is expressed from this chromosome. However, the exact mechanisms regulating their expression and the possible similarities in regulation between these genes and genes from the active X chromosome are unknown. TAXi-ch aims to determine the TFs driving the expression of genes from the Xi chromosome, as well as, the contribution of each TF to this process and their cooperativity. Specifically, an interdisciplinary approach based on functional genomics techniques, machine learning algorithms and genome editing tools will be applied to: 1) predict TFs that bind regulatory regions in the X chromosomes and generate their binding profiles, 2) assess the contribution of TFs to gene expression through classification models and targeted depletion of TFs, 3) infer regulatory networks of X-linked genes in the Xi chromosome, 4) model the transcriptional effect of abolishing binding of different combinations of TFs using 2 selected networks, and 5) experimentally validate the modelling predictions. The research is innovative, as this question has not previously been addressed using integration of allele-specific multi-omics data, and timely, considering the current interest to understand TF cooperativity. Furthermore, the results of this project will be important to the study of X-linked disorders. The dual expertise on data analysis and molecular biology of the experienced researcher ensures the feasibility of the project, and its implementation will hone her technical and transferable skills to facilitate her future establishment as an independent leader in the European Research Area.

Keywords: transcription factors,x chromosome inactivation,integrative analysis,multi omics,gene regulatory networks,crispr,cas9 technology
COllective ROBOtics through Real-time Entrainment of Evolved dynamical Systems (COROBOREES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2024-01-25
Duration (months): 24.0
Total project cost (EUR): 202158.72
EU funding (EUR): 202158.72
Participants: 1
Project status: SIGNED

Socially interacting robots are widely envisioned to revolutionise learning and care, and as they become more ubiquitous, to perform tasks collaboratively. However, despite astounding progress in engineering adaptive capabilities in fundamental behaviours such as locomotion, social behaviour is still generally considered a separate 'add-on' component. COROBOREES will contribute to efforts to provide a bottom-up approach to social behaviour in automated systems. Combining methods from evolutionary robotics, collective behaviour and sound and music computing, the project will investigate ways to incorporate social information into the motion controllers of virtual agents, and to study how this can enable synchronisation of complex movement patterns. Specifically, the project will build on the central pattern generator (CPG) framework for robot motion. CPGs are widely used in robotic controllers for cyclic motions such as walking, and may include feedback mechanisms so that robots can adapt to new tasks and environments. Using evolutionary methods, COROBOREES will compare mechanisms for entrainment to rhythmic acoustic patterns as well as acoustically transmitted social cues. Methods from sound and music computing will be used to evaluate the complexity and synchronisation of the collective rhythms generated. In addition to the innovation within robotics, this work will result in a unique simulation platform for collective behaviour, complete with built-in sensorimotor mechanisms, for the use of researchers in artificial life, biology and neuroscience. The broadly applicable training-through-research nature of the action, the contact with numerous fields of research, as well as a tailored and extensive focus on transferable skills, will provide the Experienced Researcher with invaluable knowledge and experience for leading applied interdisciplinary research in the future.

Keywords: collective behaviour
The Political Economy of Power Relations (PolEc)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Italy
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-09-30
Duration (months): 73.0
Total project cost (EUR): 1540625.0
EU funding (EUR): 1540625.0
Participants: 1
Project status: CLOSED

Political economists want to understand conflict, electoral competition, special interest politics, regimes and institutional choices, and in all these subfields the term power appears frequently: power of countries, power of ethnic groups, power of interest groups, power of parties, power of the bureaucracy. Power is multidimensional and endogenous, and hence the standard theoretical and empirical analysis that takes a unified notion of power as an independent variable has led to wrong directions. By acknowledging that power is multidimensional and endogenous, and thereby studying the endogenous interactions between the different types of power, we can further significantly the frontier of political economy. In particular, I am going to show, theoretically and empirically, that all kinds of conflict, from civil war to interstate war and even class conflict, depend on the “mismatch” between the relative power of the key players on different dimensions, for example military and political power. An important byproduct of the mismatch theory is for the interpretation of the history of conflict after 1950: I claim that it is Bretton Woods that created the ground for a significant discontinuity, cutting down the incentives to interstate wars but increasing the incentives to start civil wars. Finally, the general idea that the dynamics of one type of power can depend significantly on relative power in other spheres will be applied also to the relationship between political power and the power of bureaucracies. The empirical part of the project will involve new measurements of power and will benefit from collection of data on political texts, policy platform texts, legal texts and economic strength of ethnic groups over time and cross-countries.

Keywords: balance of power,conflict,bureaucracy,populist policy making
Facilities for testing orbital and surface robotics building blocks (FACILITATORS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Germany,Spain,United Kingdom
Call: SRC - Space Robotics Technologies (H2020-COMPET-2016, 2016)
Start date: 2016-11-01
End date: 2019-02-28
Duration (months): 28.0
Total project cost (EUR): 1003478.75
EU funding (EUR): 1000000.0
Participants: 5
Project status: CLOSED

The FACILITATORS goals are: -To Enable the highest possible level of validation of the common building blocks (developed by concurring operational grants) in the most relevant environment by adapting and providing the best available European test facilities, as well as -To Guarantee coherence among the different test facilities and among the building blocks by establishing common implementation/validation scenarios (to be reproduced during ground testing) and common interfaces with the test facilities. More concretely, in order to achieve such goals, the objectives of our project are to: 1. Analyse and identify the validation needs of each building block 2. Identify and adapt the already-existing top-notch European test platforms that will form a “federation of facilities” which will host the validation tests of ALL building blocks in BOTH demonstration scenarios 3. Characterize the facilities and provide representative datasets to support the design and development of the building blocks, carried out by concurring operational grants (OGs) 4. Ensure coherence among the different building blocks by agreeing on common demonstration scenarios that will be carried out within the federation of facilities, as well as by preparing common interfaces in coordination with the SRC board and the other parallel OGs 5. Provide easy access to the identified facilities, and ensure their availability when the building blocks will be tested 6. Assist the building blocks validation tests’ execution by providing monitoring and measuring means, as well as giving on-site support. The “Federation of Facilities” concept lies in a network of coordinated, complementary and exchangeable state-of-the-art facilities across Europe, identified, made available to the SRC, adapted and (if needed) enhanced for the scope of: -Validating the building blocks developed in the other parallel operational grants and -Providing regulated services to the space robotics community beyond this project.

Keywords: validation facilities
The effect of future global climate and land-use change on greenhouse gas fluxes and microbial processes in salt marshes (MarshFlux)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-04
End date: 2023-01-03
Duration (months): 36.0
Total project cost (EUR): 276498.24
EU funding (EUR): 276498.24
Participants: 2
Project status: CLOSED

Coastal wetlands are globally important ecosystems providing valuable ecosystem services, such as carbon sequestration over long timescales, affecting global carbon cycling and climate modulation. The amount of carbon sequestered, and therefore the net long-term global cooling potential of coastal marshes, however, is affected by complex biogeochemical reactions in marsh soils, which may produce and/or consume all three of the major greenhouse gases (GHGs) (carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O)). The magnitude and direction of these fluxes, and whether marsh soils act as a source or sink of GHGs, is affected by a variety of environmental factors which are predicted to vary with projected global change. MarshFlux, therefore, aims to address fundamental gaps in understanding of how the global cooling potential of coastal marshes will be affected by responses of biogeochemical reaction rates and GHG fluxes to global change. The effect of multiple drivers of global change on the response of GHG fluxes and key microbial processes for the consumption and production of N2O and CH4, will be investigated using a novel combination of laboratory incubations and mesocosm experiments. Laboratory incubation experiments mimicking modelled global change scenarios will be conducted to constrain the effects of drivers on marsh soil biogeochemical reaction rates and subsequent GHG dynamics, focusing on temperature, nutrient-loading and salinity. The results of these experiments, while critical themselves, will then inform mesocosm experiments to allow for the assessment of the whole ecosystem (soil, water and vegetation) response to global change under current and predicted future conditions. This research is critical for effective management of coastal wetlands to maintain their blue carbon value under future global change.

Keywords: salt marsh,greenhouse gas flux,climate change,land use change,global cooling potential
Bioconductive Iongels for Cutaneous Electrophysiology (BIKE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: France,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 173076.61
EU funding (EUR): 173076.0
Participants: 2
Project status: CLOSED

Bioelectronics is limited by the materials that transducer signals across the interface between biology and electronics. For example, in cutaneous recording, the interface between the electrode and skin is the key parameter to get a good recording. For these applications, there is a great deal of interest in developing soft conducting coatings that decrease the impedance between the electrode and the skin. Hence, the interface between the skin and the electrode is improved allowing an easier flow of the ionic and electronic current. Although hydrogel based electrolytes are in use, the continuous evaporation of water does not allow the long-term cutaneous recording. The current proposal is aiming at exploring innovative materials such as iongels that can enhance the ionic conductivity and decrease the impedance with the human skin without suffering evaporation during the recording due to the negligible vapour pressure of ionic liquids. These cutaneous electrodes will be used to monitor the electrical activity of specific organs for a better understanding of the physiology and the pathology of different organs. The Marie Skłodowska-Curie Individual Fellowship will open the best career possibilities for Dr. Ana Sanchez. After a successful PhD and 2 year post-doc in polymer chemistry in the University of the Basque Country in Spain, she decided to move to a different environment where she can exploit all her materials science expertise. The Department of Bioelectronics in EMSE directed by Prof. Malliaras in Aix-en-Provence (France) is one of the top-class groups in the emerging area of bioelectronics, where the electronics and biology converge. This multidisciplinary environment not only will broaden the scientific knowledge of Dr. Ana Sanchez in a hot topic such as bioelectronics, but also will help her to grow and to expand her network in her way to reach a future group leader position.

Keywords: ionic liquids,iongel,poly ionic liquids,bioelectronics,organic electronics,conducting polymers,electrophysiology
Advanced e-marketplace for a new way of purchasing and sharing Home Care Services and Assisted Living Technologies (HoplaCare)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: United Kingdom
Call: New business models for inclusive, innovative and reflective societies (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-02-01
End date: 2017-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

European population is fast ageing: in the next future, this means increasing rates of care-dependent older people and a rapidly growing need for domiciliary healthcare services, due also to the progressive unavailability of informal care. Most of the citizens will not have access to public care and will refer autonomously to care providers. The search of a trusted and skilled professionals is time consuming and there is not any guarantee on the quality of the service, except by word of mouth. For professionals the need to find easily and continuously demand is vital. Traditional commissioning processes are opaque, inflexible and do not fit with users’ needs. HoplàCare platform offers: - to families all that is needed to properly take care of their elderly relatives, from finding the best care provider/service to being always connected with their loved one accessing Real Time Home Care Monitoring systems (remote care assisted living); - to providers more responsive and flexible services and it gives to the smaller a transparent, easy channel to reach new users and enter the market. The platform is an advanced e-marketplace that standardizes the trade of home care services. Trust and professionalism are assured by a continuous validation held by the iterative ranking algorithm that evaluates the reliability of healthcare professionals. HoplàCare integrates informal and formal care, by coordinating the care supplied from different carers (public and private) to that of relatives themselves and offers the unique opportunity to access to care sharing. Given that CaringMate intends to rapidly scale the model on the EU market, this implies the release and validation of an optimized public full operational version of the platform and of the mobile app, integrating all the remote care features (i.e. webcam service); during phase 1, a feasibility study (commercial, financial, technical) will be carried out and a solid go-to market strategy and pilot action designed.

Keywords: home care,healthcare,well ageing,care sharing,remote care,e marketplace,assisted living,elderly,disabled
The European Industry - Academia Network for RevIsing and Advancing the Assessment of the Soil Microbial TOxicity of Pesticides (ARISTO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Germany,Germany,Germany,Israel,Belgium,Sweden,Switzerland,Greece,Switzerland,Greece,France,France,France,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2020-12-01
End date: 2024-11-30
Duration (months): 48.0
Total project cost (EUR): 2390825.04
EU funding (EUR): 2390825.04
Participants: 17
Project status: SIGNED

In ARISTO (the European Industry - Academia Network for RevIsing and Advancing the Assessment of the Soil Microbial TOxicity of Pesticides), leading universities and industrial partners join forces to perform a cutting edge research and doctorate training programme tackling the global challenge of minimising the environmental off-target effects of pesticides. The multi-sectoral approach of ARISTO, interlinking disciplines from soil microbiology, microbial ecology, environmental chemistry and risk assessment, will generate the new generation of Microbial Ecotoxicologists specialized in pesticides-soil microbes interactions. The research challenge of ARISTO is to produce benchmarking knowledge supporting the development of advanced tools and procedures, based on the response of key microbial indicator groups like ammonia-oxidizing microorganisms (AOM) and arbuscular mycorrhizal fungi (AMF), for the comprehensive assessment of the toxicity of pesticides on soil microorganisms. ARISTO offers doctorate fellows a challenging training programme build along 5 research objectives: (1) to develop pioneering in vitro tests, as a first conservative step, to assess the toxicity of pesticides on distinct AOM (ESR1) and AMF (ESR2) strains (2) to develop advanced experimental lab and field tests to assess the toxicity of pesticides on natural soil assemblages of AOM (ESR3) and AMF (ESR4), as a more realistic toxicity assessment step (3) to develop an ecosystem-level toxicity assessment: identify the response of soil microbial networks to pesticides (ESR5) and explore the impact of pesticides on microorganisms from different trophic-levels within the soil food-web (predator - prey) (ESR6) (4) to develop novel tools and procedures to determine the soil microbial toxicity of pesticide mixtures (ESR7) and biopesticides (ESR8) (5) to develop & validate advanced in silico tools for prioritizing transformation products (TPs) of pesticides with potential toxicity to soil microbes (ESR9)

Keywords: pesticides,ecotoxicity,soil microorganisms,arbuscular mycorrhizal fungi,ammonia oxidizing microorganisms,microbial networks,soil food web,pesticides transformation products