Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reshaping undesired Inflammation in challenged Tissue Homeostasis by Next-Generation regulatory T cell (Treg) Approaches – from Advanced Technology Developments to First-in-Human Trials (RESHAPE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Italy,France,France,United Kingdom,United Kingdom
Call: Innovation platforms for advanced therapies of the future (H2020-SC1-2018-Single-Stage-RTD, 2018)
Start date: 2019-01-01
End date: 2023-12-31
Duration (months): 60.0
Total project cost (EUR): 13137396.25
EU funding (EUR): 13137396.25
Participants: 11
Project status: SIGNED

Adoptive transfer of regulatory T cells (Treg) is a promising new therapeutic option to reshape undesired intra-tissue immune imbalance in immune-related disease entities. It supports long-term function of allografts and use of Advanced Therapy Medicinal Products (ATMP) by overcoming the challenge of unwanted immune reaction by the recipient of the ATMP. Therefore, adoptive Treg therapy is a potential game changer in health care, particularly in immune diseases, organ & hematopoietic stem cell (HSC) transplantation, and regenerative medicine, including gene therapy. Based on the Triple-T concept - Transdisciplinarity, Technology, Translation - the major goal of RESHAPE is to transform the treatment of patients suffering from undesired immunity/inflammation, who presently have limited curative treatment options, by applying novel Treg approaches that overcome the limitations of 1st generation Treg product developments. Members of the consortium, with academic & biotech backgrounds, are pioneers in the development of Treg therapy from basic science to very recent encouraging First-In-Human (FIH) clinical trials of the 1st generation Treg products. They have a longtrack record of collaboration, including in EC-funded projects. The first clinical trials were performed to combat organ transplant rejection and Graft-versus-Host-Disease. However, promising preclinical studies offer a broad application field of Treg therapy beyond allotransplantation. Based on our preclinical & clinical data, we have identified several opportunities for improving Treg therapy, such as enhanced antigen specificity & functional stability, and recipient conditioning, that will be addressed by RESHAPE. The next-generation Treg products, developed by advanced technologies including CRISPR/Cas9, will be tested on platforms applying new methods for cell characteristics in both in vivo /in vitro models, and finally proven in FIH-clinical trials accompanied by biomarker and health economic studies

Keywords: regulatory t cells,atmp,reshape inflammation,immunomodulation,humanized rodents,human on the chip technology,car treg,tcr treg,crispr,cas9,virus free gene delivery,first in human trials
Post-quantum cryptography for long-term security (PQCRYPTO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Israel,Germany,Taiwan, Province of China,Belgium,France,Netherlands,Netherlands,Denmark
Call: Cybersecurity, Trustworthy ICT (H2020-ICT-2014-1, 2014)
Start date: 2015-03-01
End date: 2018-02-28
Duration (months): 36.0
Total project cost (EUR): 3964791.25
EU funding (EUR): 3851791.25
Participants: 11
Project status: CLOSED

Online banking, e-commerce, telemedicine, mobile communication, and cloud computing depend fundamentally on the security of the underlying cryptographic algorithms. Public-key algorithms are particularly crucial since they provide digital signatures and establish secure communication without requiring in-person meetings. Essentially all applications today are based on RSA or on the discrete-logarithm problem in finite fields or on elliptic curves. Cryptographers optimize parameter choices and implementation details for these systems and build protocols on top of these systems; cryptanalysts fine-tune attacks and establish exact security levels for these systems. Alternative systems are far less visible in research and unheard of in practice. It might seem that having three systems offers enough variation, but these systems are all broken as soon as large quantum computers are built. The EU and governments around the world are investing heavily in building quantum computers; society needs to be prepared for the consequences, including cryptanalytic attacks accelerated by these computers. Long-term confidential documents such as patient health-care records and state secrets have to guarantee security for many years, but information encrypted today using RSA or elliptic curves and stored until quantum computers are available will then be as easy to decipher as Enigma-encrypted messages are today. PQCRYPTO will allow users to switch to post-quantum cryptography: cryptographic systems that are not merely secure for today but that will also remain secure long-term against attacks by quantum computers. PQCRYPTO will design a portfolio of high-security post-quantum public-key systems, and will improve the speed of these systems, adapting to the different performance challenges of mobile devices, the cloud, and the Internet of Things. PQCRYPTO will provide efficient implementations of high-security post-quantum cryptography for a broad spectrum of real-world applications.

Keywords: mobile devices,cloud security,internet of things,public key cryptography,secret key cryptography,mceliece encryption,mq signatures,hash trees,ntru,lattices,side channel attack
Carrier-selective contacts for silicon photovoltaics based on broadband-transparent oxides (COLIBRI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-06-01
End date: 2018-05-31
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

This project aims at a cost-effective efficiency enhancement of Si solar cells towards their theoretical maximum of about 29% by moving away from the diffused-junction paradigm. This will reduce the energy fabrication costs on the €/kWh level and thereby increase the competiveness and profitability of photovoltaic systems. Crystalline Si (c-Si) solar cells are since decades the most established photovoltaic technology. Their main advantages are long lifetime (>25 years), non-toxicity and the high abundance of Si. However, for full competitiveness with traditional sources of electricity, important new steps need to be taken to increase their performance. An innovative contacting scheme will be developed that eliminates the main loss mechanisms in c-Si solar cells arising from doped pn-junctions and the direct contact of metal with Si. The novel contacts will be broadband optically transparent, generate a highly passivating and carrier-selective interface to Si and will enable solar cells without doped pn-junctions. No cost-intensive patterning technique is required for the device fabrication and parasitic optical absorption, as present in Si heterojunction solar cells, will be minimized. The novel contacts consist of three layers: a 1-2 nm thick tunnelling SiO2 layer for chemical passivation of the Si surface, a wide-bandgap conductive metal oxide layer providing a specific energy band alignment, and a highly conductive transparent oxide (TCO) for carrier transport to external metal contacts and optimum light coupling into the solar cell device. The contacts will be used for the fabrication of Si solar cells which are devoid of doped pn-junctions and achieve both high open-circuit voltages and photo currents. The structure of the photovoltaic device will be optimized for the application in regular 1-sun modules and for both III-V/Si and perovskite/Si tandem cell applications with potential for flat-plate efficiencies well above 30%.

Keywords: high efficiency photovoltaics,c si solar cells,carrier selective contacts,tandem solar cells
Setting up high-value sea cucumber chain in Europe through a new fishing gear with no environmental impact and advanced processing equipment (TOPBALAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: SME instrument
Countries involved: Iceland
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-09-01
End date: 2021-07-31
Duration (months): 47.0
Total project cost (EUR): 2436825.0
EU funding (EUR): 1705777.5
Participants: 1
Project status: CLOSED

AURORA SEAFOOD is the Icelandic SME currently leading the incipient Sea Cucumber (SC) industry in Iceland —the leading country in the SC business in Europe. The seafood fishery and processing industries are claiming for long-term sustainable and efficient innovations that assure the economical profitability of business. Firstly, the high percentage of the costs of raw material, due to low availability of traditional species at sea, creates the need for species diversification. Europe still has huge potential to exploit other species highly valued in international markets. Secondly, the intensive manual labour in the production of seafood goods poses a risk. TOPBALAT represents an integrative approach to establish for the first time in Europe an advanced SC value chain comprising SC fisheries and processing industry. SC have a high commercial value, and global demand is increasing led by China, the first economy of the world. The innovation of TOPBALAT lies in the resource exploited, the SC-specificity of the technology, and the way our technology components set up a value chain for the whole business. Our approach tackles fishing, automated processing and distribution, and allows for other companies to tap on this market with the introduction of European processed dry SC at competitive prices in the Asian market. TOPBALAT’s specific SC technology saves costs: 20% less total costs due to increased manoeuvrability, reduced gear loss, increased catching efficiency (70%), reduced by-catches (5%), only 5% of meat discards in the processing, and 90% less distribution costs. AURORA will commercialise the final product (dried whole fully processed SC) and the technology to harvest and produce it. TOPBALAT’s product target users are the middle-upper class in China, and our technology target users are seafood companies in Norway, Scotland and Ireland. By 2022, we expect sales of 325 tonnes of processed SC, accumulated gross revenues of €25.2 M, and 7-10 new jobs creation.

Keywords: seafood,sea cucumber,seafood processed products,seafood exports,trawling,dredging,fishing gear,processing equipment,b che de mer,blue growth
Transition metal oxides with metastable phases: a way towards superior ferroic properties (TransFerr)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Ukraine,Germany,Lithuania,Belarus,Poland,Portugal
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2017-12-01
End date: 2023-08-31
Duration (months): 69.0
Total project cost (EUR): 625500.0
EU funding (EUR): 625500.0
Participants: 9
Project status: SIGNED

The main objective of the project is development of complex transition metal oxides with perovskite-like structure having improved and controllable (multi)ferroic properties. The mentioned materials are manganites and ferrites with optimal composition having distinct magnetization, polarization, (magneto)transport properties or magnetoelectric coupling. The idea of the project is to utilize reduced structural stability of these oxides which increases their sensitivity to external stimuli. Improved functional properties of these oxides can be controlled via modification of the chemical bond character, structural parameters, stoichiometry, defects etc. The reduced stability is associated with the metastable structural state formed in the vicinity of the phase boundaries, while this state presumably consists of coexistent nanoscale regions of the adjacent structural phases. There are two ideas to create metastable state: the first one – to design ceramics via chemical substitution and post-synthesis treatment by high pressure and/or thermal cycling in gases to induce nanoscale regions, the second one assumes chemical routes synthesis of films and ceramics. Besides the fundamental interest of the phase transitions and related phenomena affecting properties of the oxides the applicants consider them to be effective materials for electronic applications (as sensors, magnetic memory elements, filters etc.). Research of these oxides requires consolidative efforts of specialists in different scientific areas - Materials Science, Theoretical Physics, Solid State Physics etc. as well as an access to unique equipment and facilities. Another important objective of the project is a formation of interdisciplinary network of teams and specialists with different scientific backgrounds which will ensure effective transfer of actual knowledge and skills. Development of the transition metal oxides with controllable properties has promising commercial opportunities for the involved SME.

Keywords: multi ferroics,functional materials,crystal and magnetic structure,spin and structural phase,transitions,metal insulator transition
Theoretically-Sound Real-World Cryptography (REWOCRYPT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-04-01
End date: 2024-03-31
Duration (months): 60.0
Total project cost (EUR): 1498638.0
EU funding (EUR): 1410788.0
Participants: 2
Project status: SIGNED

Novel technologies like Cloud Computing, Ubiquitous Computing, Big Data, Industry 4.0, and the Internet of Things do not only come with a huge demand for practical and efficient cryptosystems, but also with many novel attack surfaces. The security properties required from cryptographic building blocks for these innovative applications go beyond classical security goals. Modern theoretical cryptography has very successfully developed powerful techniques that enable the design and rigorous formal analysis of cryptosystems in theoretical security models. Now that these techniques are readily available, we have to take the next important step: the evolution of these techniques from idealized theoretical settings to the demands of real-world applications. The REWOCRYPT project will tackle this main research challenge at the intersection of theoretical and real-world cryptography. It will provide a solid foundation for the design and mathematically rigorous security analysis of the next generation of cryptosystems that provably meet real-world security requirements and can safely be used to realize secure communication in trustworthy services and products for a modern interconnected society.

Keywords: provable security,real world cryptography,cryptographic protocols
The Arts of Autonomy: Pamphleteering, Popular Philology, and the Public Sphere, 1988-2018 (ArtsAutonomy)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Germany
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2026-02-28
Duration (months): 72.0
Total project cost (EUR): 1229665.0
EU funding (EUR): 1229665.0
Participants: 1
Project status: SIGNED

Concise, massively ideological texts have long been perceived as constitutive of the development and transformation of opinion and policy in the public sphere. At least since the early Enlightenment, the pamphlet has been at the forefront of major philosophical, social, and political transformations, including processes of democratization and dedemocratization, colonization and decolonization, the universalization of civil and civic rights, the enforcement of political or territorial autonomy, and the critique of labor exploitation. Since the fall of the Berlin Wall, pamphleteering has reemerged as a vital transformative and polemical force in liberal Western societies, prompting often polarized discussions of contentious issues. By integrating philological, historical, and politological research perspectives, ArtsAutonomy will produce a first systematic, large-scale account of contemporary pamphleteering and shed new light on the perceived ongoing radicalization of political, cultural, and social ideals and discourses in contemporary Europe and the United States. We intend to achieve our epistemic goals by studying “pamphletary events”, i.e. events which unfold in the public sphere and which engage both a pamphletary text and interpretative competences widely distributed among the general reading public. ArtsAutonomy will produce several thematically organized case studies of pamphletary events, including analytic “slices” of evolving public opinion on pamphletary statements, as recorded in transcripts of public deliberations, open letters, online commentary, user and consumer feedback, and social media. Our multidisciplinary approach will provide a unique insight into the concrete current political agency of one of the oldest literary forms, as well as into the philological-interpretative competences upon which pamphletary events and their normalization are predicated.

Keywords: pamphleteering,philology,polemic,virality,policy,civic turn
The first commercial CubeSat Constellation for early detection and real time monitoring of wildfires across the entire globe (OroraTech)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

OroraTech aims to launch a constellation of 100 CubeSats (the biggest one in Europe and the third biggest in the world) to provide high resolution thermal images of the entire globe enabling the automatic detection and real time monitoring of wildfires across the globe. Fuelled by rising temperatures, wildfires have become more common, deadly, expensive and difficult to contain, resulting in over 200 deaths and damage >€23bn in the EU and US alone, in 2018. Their causes are unpredictable and so the only solution is early detection and suppression. With 4% of the earth’s surface affected, there are no technologies to viably provide continuous high resolution monitoring, with current satellite technology either having a too low resolution or inadequate overpass frequency. OroraTech provides a breakthrough by integrating the latest advances in miniature electronics, computing and space technology to deliver the first commercially viable CubeSat delivering high resolution thermal imaging. We will cover the whole earth at 0.1% of current satellite technology costs providing 24hr surveillance at a high resolution delivering data in a matter of minutes. This will reduce fire suppression costs by 25% and detection infrastructure capital costs by up to 90% resulting in global savings in the order of billions of euros. With wildfires contributing 20% of global CO2 emissions annually, our solution potentially reduces global CO2 emissions by >2%. We are attacking a high growth market worth over €7bn/yr by 2027 with over 16 million potential customers in EU alone. We have already received the support of the German Aerospace Centre, European Space Agency, and Global Fire Monitoring Centre, and attracted the attention of the biggest forest service (US) in the world.

Keywords: ororatech aims to launch a constellation of 100 cubesats the biggest one in europe and the third biggest in the world to provide high resolution thermal images of the entire globe enabling the autom
Delivering Hydroacylation: A General and Enantioselective Process (DEGENHA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This proposal outlines the development of a suite of truly general hydroacylation catalysts that demonstrate high levels of functional group tolerance, enantioselectivity, broad applicability and ease of use in the laboratory. These advances will be achieved by the development of a new modular ligand system, based on the small-bite angle hemilabile diphosphines. By achieving these advances hydroacylation will become a general and robust disconnection for the synthesis of fine and bulk chemicals, new materials and target molecules.

Keywords: hydroacylation,enantioselective,alkene,chiral phosphine