Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Encoding of episodic memory in hippocampal rigid and plastic neurons (RigidPlasticNeurons)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: SIGNED

One of the remarkable features of the mammalian brain is its capability to learn. This is particularly evident during infancy, when novel context is rapidly integrated and transformed into new memory. How early-life experiences are encoded in the developing hippocampus, a brain region central to the formation and recall of memory, has not been well understood. We know very little how neural populations in the hippocampus are activated during learning, allowing for both a generalised yet flexible encoding of information. Recent work suggests that a subset of hippocampal neurons show more rigid, stable activation patterns across the behavioural domain while others are more plastic. How their properties emerge during infancy and evolve during brain maturation is the centre of this proposal. To answer these questions, I propose to study the ensemble code in the developing mouse hippocampus. I will use a combination of calcium imaging, viral labelling, and chemogenetic techniques paired with a behavioural navigation assay to measure in vivo the activities of 100s of neurons while the animal explores known and novel environments. Specifically, it is my ambition to understand how the functional properties of rigid and plastic neurons in CA3 region emerge during development and to identify the neural circuitry encoding episodic memories in the infant and adult brain. By bridging developmental, systems, and behavioural neuroscience, the proposed research will provide highly novel contribution to our understanding of learning during brain maturation.

Keywords: calcium imaging,virtual reality,hippocampus,entorhinal cortex,episodic memory
Immersive Cabin (IMCA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Netherlands
Call: Technology evaluation of immersive technologies for in-flight applications (H2020-CS2-CFP02-2015-01, 2015)
Start date: 2016-07-01
End date: 2019-01-31
Duration (months): 31.0
Total project cost (EUR): 368385.0
EU funding (EUR): 315529.5
Participants: 2
Project status: CLOSED

Exponential technologies are emerging on the market that, when placed in the context of air transport aircraft, enables new functionalities and business models with the potential to enrich the (both mental and physical) passenger well-being, improve the in-flight experience and contribute to an increase of operational efficiency for the airline and airline cabin staff. Although most attention is naturally drawn to the individual application that creates the new business values, a thorough understanding of the underlying infrastructure building blocks, the way these technologies can be used on board transport aircraft, and understanding how these technologies would impact both passenger and cabin crew during flight operations is as important. This project aims to evaluate the use of immersive technologies such as virtual reality and augmented reality in relation to exponential technologies within a cabin environment, to enable them to be used by passengers and cabin crew during (revenue) flight operation. The fundamental question to be answered in this project is how suitable these immersive technologies are for: 1. Increasing well-being of passengers and cabin crew (human factors); 2. Generating ancillary revenue; and 3. Improving operational efficiency. Focus areas within the project are formulated around: 1. Enrichment of the stay of passengers in the cabin space by influencing the field of view. 2. Coordination and cooperation between passenger and cabin crew. 3. Interaction between cabin crew members and cabin crew member with passengers. 4. How the aircraft technology eco-system for hosting exponential technologies inside an aircraft should look like (Architectural point of view) 5. Possibility to extent the aircraft technology eco-system from within the aircraft into the daily life of the passenger/crew member.

Keywords: augmented reality,virtual reality,customer journey,door to door,immersive cabin,ancillary revenue generation,passenger well being,passenger health,cabin crew,airline operations,concept demo
Ensuring pipeline integrity using Earth Observation Data (CSAR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Netherlands
Call: SME Instrument (H2020-SMEINST-1-2014, 2014)
Start date: 2015-03-01
End date: 2015-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Third Party Interferences (TPIs) are responsible for a large part of all failures in transmission pipelines. Examples of TPIs are excavations, construction activities, dredging, etc.. An efficient monitoring service for (short lived) TPIs requires high resolution data, a high revisit rate and needs to be dependable. These requirement cannot be filled by any single satellite mission alone. A feasibility study is proposed to investigate the quality of detection of TPIs when combining Sentinel-1 images at a high revisit frequency with higher resolution data acquired with a low revisit frequency. The results of this study will be integrated in the existing Orbital Eye infrastructure for pipeline integrity monitoring. This will result in a system that is fully automatic and continuously operational, can monitor both long and short lived TPIs and has an operational cost that is considerably lower compared to existing solutions. No such system currently exists on the European market, creating a unique business opportunity.

Keywords: earth observation,pipeline integrity,syntactic aperture radar,sentinel 1,terrasar x,space
Development of a Microfluidic Microbial Ecology Device and Mathematical Model to Study Antibiotic Response of Individual Cells (MMED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Türkiye
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-14
End date: 2022-01-14
Duration (months): 24.0
Total project cost (EUR): 145845.6
EU funding (EUR): 145845.6
Participants: 1
Project status: CLOSED

To discover effective strategies against antimicrobial resistance, a deeper understanding of microbial behaviour in their natural ecologies is crucial. The essential technological bottleneck that has limited our capability to explore this issue is the microenvironment provided by batch culture assays. They are incapable of mimicking natural microhabitats, quantifying individual bacteria, and revealing antibiotic resistance. Therefore, development of a theoretical and experimental framework that mimics the natural microecology of bacteria and measuring their antibiotic response to predict optimum survival strategies will provide valuable tools to investigate bacterial individuality and their changing response to antibiotics in realistic microenvironments.

Keywords: microfluidics,active matter,antibiotics
Novel nanomedicine for the treatment of glioma (EDROMA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-03-01
End date: 2018-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Lisapharma, an Italian pharmaceutical SME, aims to bring on the market Edroma: a new product based on a nanotechnology platform to treat malignant high-grade gliomas (HGG), for which there are no satisfactory curative methods. High-grade gliomas are the most aggressive type of brain cancer. Despite recent advances in treatment, the prognosis for patients with HGG is dismal: so far the most effective treatment, radiotherapy, brings an increase in median survival from 3-4 months to around 9-10. The Edroma medicinal product is a dispersion for injection made of nanoparticles encapsulating the active ingredient zoledronic acid, resulting by a self-assembling procedure made possible by Lisapharma’s patented platform. Compared to the current brain-cancer therapy solutions, Edroma innovation brings significant improvements in terms of higher efficacy and lower toxicity. Pre-clinical tests on mice demonstrated tumour reduction, increased life-expectancy and even, in one case out of 6, complete cure. Lisapharma has obtained the orphan designation from both EMA and FDA. This represents a unique business opportunity, as Lisapharma will be the only authorised provider of the new product for 10 year (7 in USA). It is estimated that the number of treatable cases in EU and USA could reach 20,000 subjects for which there are no alternative curative therapy. Considering 15,000 € per treatment cycle, the values of this potential market approximate 135 M€, and Lisapharma intends to reach 30% of this market in 5 years. The project has the potential to boost growth of Lisapharma by increasing significantly the company turnover. The total investment required is about 4.5 M€ over 3 years, for clinical studies, equipment and industrialisation, marketing and business development, with a foreseen ROI (internal return rate) of 122%.

Keywords: nanomedicine,glioma,orphan designation
Machine Learning for Computational Dynamics (MALCOD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2017-08-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

The proposed research aims to establish groundbreaking new methods for the numerical analysis of dynamical systems by using tools from the field of machine learning. The intersection of the fields of machine learning and computational dynamics is largely unexplored, and this proposal aims at the first systematic development of a unified theory, with a view to applying the ideas to problems in the commercial and energy sectors. Recent results by the applicant in set approximation for control systems demonstrate the power of this approach, the results of which significantly improve on the current state-of-the-art methods for set approximation. This approach is based on a functional analytic framework frequently exploited in modern machine learning methods: the reproducing kernel Hilbert space (RKHS). Algorithms are designed to seek functions in the RKHS that characterise important dynamical properties of the system. This highly interdisciplinary research programme will develop a powerful and unified approach to create new algorithms that can either use input data generated from the evolution equations (if they are available) or measured data obtained directly from applications. The host institution PIK is a transdisciplinary host institution focused on climate modeling and sustainability. The tools developed during the course of the fellowship will be applied to the problem of basin stability and synchronisation of power grid networks. This proposal also includes two secondment phases to be spent at the non-academic partner organisation Ambrosys GmbH (AMB). There, the applicant will apply the research results to problems in image rendering in movies and turbulent flow across aerofoils, which are commercial applications already studied at AMB. The applicant will benefit from training in climate modeling and complex systems at PIK, and industrial training during the secondment phases.
Multiple Perspectives on Grammatical Gender in the Bilingual Lexicon (GenBiLex)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Norway
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-01
End date: 2020-04-17
Duration (months): 24.0
Total project cost (EUR): 208400.4
EU funding (EUR): 208400.4
Participants: 1
Project status: CLOSED

Grammatical gender represents an important area of research given the difficulty gender assignment and agreement poses to bilinguals at all levels of proficiency. As such, the objective of GenBiLex is to develop a comprehensive proposal of grammatical gender in the bilingual lexicon that includes psycholinguistic, language acquisition and theoretical linguistic approaches. Little previous research has examined the consequences of differences between the L1 and L2 gender systems, either in terms of the number of gender values (e.g. 2 vs 3 values) or the values themselves (e.g. common/neuter vs masculine/feminine). GenBiLex addresses this crucial gap by examining bilinguals with different types of gender systems in order to offer insight into the representation of and interactions between the L1 and L2 gender features in the lexicon and how this is borne out in the use of gender in the L2. In this research 140 adult native speakers (L1) of Norwegian, German, Dutch and French learning Spanish (L2) perform an L2 gender decision task (indicate the gender value of L2 nouns) and an eye-tracking reading acceptability judgment task (rate sentences with code-switched Determiner Phrases, e.g. die mesa, ‘theGER tableSPA’). The stimuli are manipulated in terms of the gender congruency between the L1 and L2 nouns, allowing for the representation and use of gender in the L2 to be examined and bilinguals’ use of gender agreement in code-switching to be investigated with respect to theoretical syntactic proposals. GenBiLex complements previous work on grammatical gender by the Language Acquisition, Variation and Attrition group at the University of Tromsø, extending their research to include L2 acquisition and more language pairings. The outcome of this research will be a significantly deeper understanding of the representation and processing of grammatical gender in the bilingual lexicon that contributes to psycholinguistics, language acquisition and theoretical linguistics.

Keywords: grammatical gender,bilingual mental lexicon,code switching,l2 representation,l2 processing,l1 transfer,masculine as default,determiner phrase
Topological phononics through nano-optomechanical interactions (TOPP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-06-30
Duration (months): 66.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The concept of topology has proven very powerful in predicting and explaining a range of intriguing phenomena for the behaviour of electrons in solid-state materials, including the existence of topological phases that offer robust transport with unusual characteristics. This program aims to create and study topological behaviour for sound in systems that couple light and mechanical motion through radiation pressure. I will realize on-chip nano-optomechanical systems where many optical and mechanical modes interact. Through this interaction, suitable laser illumination will induce phononic transport with properties that are not found in any natural material. In particular, they will establish topologically nontrivial acoustic phases that we will create and explore in space and time using a new optical measurement technique. The induced behaviour crucially depends on the extreme coupling between optical fields and nanomechanical resonators when both are confined at the nanoscale. I aim to study three manifestations of topological behaviour: (1) The creation of an acoustic quantum Hall phase, in which topologically protected unidirectional sound propagation should emerge, in edge modes that are robust against disorder. (2) The formation of a new type of topological insulator arising from optomechanical nonlinearity, supporting topological acoustic solitons with unusual dynamics. (3) The breaking of parity-time symmetry in mechanical systems that undergo both optical damping and amplification, a phase transition with unique topological properties.
Single electron detection in Transmission Electron Microscopy (e-See)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France,France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-10-01
End date: 2025-03-31
Duration (months): 78.0
Total project cost (EUR): 1998958.0
EU funding (EUR): 1938958.0
Participants: 3
Project status: SIGNED

The ultimate goal of device miniaturization is to rely on a single charge provided by a single dopant atom: solotronics. Currently the gate length in a transistor cannot be reduced beyond 10-12 nm, as variability between nominally identical devices reaches unacceptable levels. Elaborate quantum transport experiments can monitor the presence and spin state of a single charge, but do not provide information about location and distribution (wavefunction) of the charge or the local chemical and crystallographic environment. The latter, however, determine why the charge is present at a specific location with a particular distribution. Scanning probe techniques can measure charges but are restricted to the near surface region. In contrast, the phase of an electron in transmission electron microscopy (TEM) can probe the sample volume and is sensitive to charge. The target of the e-See project is the first real time observation of the wavefunction associated to a single electron charge in the volume of a device with atomic resolution. I aim to implement low temperature quantum transport experiments in a TEM to allow simultaneous electrical manipulation of this charge. Combined visualization and manipulation of a single charge trapped by Coulomb blockade in a transistor will (i) identify the origins of device variability, and (ii) show how the local properties of the sample affect localization of a single charge and its wavefunction. The project impact involves understanding of variability, improving device design and creation of a new research field on low temperature electrical in situ TEM experiments. It will provide the tool to visualize a single charge wavefunction in any device, enabling ultimate device engineering: deterministic 3D atomic scale control of the position of charge localization. To this end, I will use electron holography and scanning TEM, develop a low temperature electrical TEM sample holder, and novel sample preparation.

Keywords: single charge,transmission electron microscopy tem,devices
Structural transformations and phase transitions in real-time (TRANSFORMER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-09-01
End date: 2024-08-31
Duration (months): 72.0
Total project cost (EUR): 2471749.0
EU funding (EUR): 2471749.0
Participants: 1
Project status: SIGNED

Chemical and material sciences are key drivers of our modern economy with transformative impact at all levels of society. In particular, the ability to synthesize and to tailor substances and materials with specific function is all-pervading into modern society. Vital is a firm understanding of structural transformations of molecules and phase transitions of solids as they are omnipresent, e.g. as formation and breakage of molecular bonds, proton motion and isomerization, and as collective phenomena in phase transitions. Gaining insight into the ultrafast correlated dynamics is highly challenging and requires revolutionary methodologies and innovative approaches to capture the dynamics from its onset. TRANSFORMER will provide unprecedented insight into the real-time electronic and nuclear dynamics of molecular transformations and phase transitions with advanced new methodologies and a multi-faceted approach to the investigation. The project exploits our pioneering achievements in attosecond soft X-ray spectroscopy (XAFS) and laser-induced electron diffraction (LIED) to pinpoint in real-time which electronic states participate at which nuclear configuration. The proposal consists of three objectives: O1: We will establish the methodical boundaries of LIED for space-time imaging of isolated molecules. O2: We will extract simultaneous and real-time electronic and nuclear information, thus gain insight into the underlying many-body quantum correlations. O3: We will use our methodology to realize resolving both, molecular isomerization and a solid’s metal-to-insulator phase transition, in its electronic and nuclear degrees of freedom and in real time. If successful, TRANSFORMER would undoubtedly provide an unprecedented view into electronic and nuclear dynamics, thereby reaching far beyond the state of the art with clear potential to surpass current limits in molecular and material sciences.

Keywords: structural dynamics,isomerization,phase transition,ultrafast x rays