Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mechanisms of earliest hematopoietic cell fate control (MOSIMANN ZEBRAFISH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-03-01
End date: 2018-02-28
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

How blood cells and ultimately hematopoietic stem cells (HSCs) arise from uncommitted cells during development is only vaguely understood. Especially the initial formation of the first blood precursors in lateral mesoderm has been difficult to dissect. Investigating these early mechanisms of blood cell fate determination with genetic model systems provides a vital starting point for therapeutic drug discovery and the targeted manipulation of iPS cells to treat hematologic diseases. The goal of the proposed research project is to elucidate the mechanisms that drive uncommitted embryonic cells into a hematopoietic cell fate by using the vertebrate zebrafish (Danio rerio). To visualize, isolate, and fate-map the earliest stages of hematopoietic cell formation, the proposed work applies transgenic zebrafish reporters under control of the newly isolated draculin gene promoter/enhancer. draculin is the earliest marker for the emergence of hematopoietic cells from lateral mesoderm during embryo development. The transgenic labeling with draculin will be harnessed for progenitor culture assays to uncover the earliest hematopoietic cell fate potential of uncommitted lateral mesoderm. These experiments will be complemented with in vivo fate mapping using Tamoxifen-controlled Cre/lox methods. The proposed study will also apply novel zebrafish microinjection approaches to test and identify transcription factor combinations that enforce blood cell fates and HSC formation. The preliminary results revealed a combination of transcription factors that ectopically induces a hematopoietic gene program in the embryo. Altogether, this work will break new ground in our understanding of the earliest blood-forming mechanisms, and provide new insight into how cells can be experimentally guided towards the therapeutically desirable HSC fate.

Keywords: zebrafish,hematopoiesis,blood,cell fate,development,mesoderm,genetics,transgenes.
Emotional attributions of climate change (EACC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-04-01
End date: 2018-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

It is now clear that managers, and their organisations, are under increasing pressure to respond to environmental issues, and to climate change in particular. Research has identified the important role that individuals play in affecting organisational change, yet more remains to be done. Despite past success of cognitive and behavioural perspectives in explaining proenvironmental behaviours, few researchers have explored its affective dimensions. The lack of affective research on environmental issues in organisations has meant that there is a lack of understanding of how emotion might affect behaviour, particularly in response to environmental issues. This proposal aims to inform this research area and identifies three key objectives to advance the state of the art by: (1) furthering understanding of the relationship between climate change attributions and emotional reactions; (2) furthering understanding of the relationship between emotional reactions to climate change and subsequent decision-making and behavioural responses; and (3) evaluating how emotions affect climate change responses over long-term change programs in organisations. The research programme described in this proposal will provide a significant move forward in the state of the art. Each objective is interrelated to the others and provides a coherent work programme that can be successfully completed over the course of the CIG award. These objectives will overcome significant limitations of past research and provide a strong platform for future research. Furthermore, the results of this research will be directly relevant to industry and will inform the ESRC’s strategic priority of influencing behaviour and informing interventions.

Keywords: climate change,behaviour,emotion,organisations,pro-environmental behaviour
Social Transport with Urban Big Data (SOCIAL TRANSPORT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Life-long training and career development
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-CIG, 2013)
Start date: 2014-05-01
End date: 2018-04-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Social Transport with Urban Big Data
Public Involvement with Exhibition on Responsible research and innovation (PIER)

Framework: FP7 — Capacities
Programme: Science in Society
Destination: Science in Society
Action type: Coordination and support actions
Countries involved: Italy
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2014-01-01
End date: 2015-01-31
Duration (months): 13.0
Total project cost (EUR): 529839.6
EU funding (EUR): 500000.0
Participants: 1
Project status: CLOSED

PIER (Public Involvement with exhibition on Responsible research and innovation) is a project to engage the public on the Responsible Research and Innovation in society. The project will develop an exhibition with a participatory programme to engage the large public on the concrete achievements of the European scientific research and innovation today, enhancing the responsible approach in the implementation of research and highlighting its implications for the territorial development and for the quality of life of citizens. The exhibition will include different means of communication and participation such as hands-on exhibits, prototypes and demonstrators, videos and multimedia products; it will be supported by public programs, which will use dialogue formats in order to engage the public in the RRI dimensions of science and technology. The exhibition will be addressed to and implemented with representatives of societal actors of the Research and Innovation process of implementation: researchers, businesses, media, educators, civil society organizations and policy-makers as well as citizens, who will be involved in different times and formats during the project. In order to address better the interest of the public, the beneficiary proposes to focus the exhibition on ocean research which is a relevant theme for citizens of the Neapolitan region, as the Mediterranean Sea is a prior element of the natural environment to preserve and a source for the economic development. The topics tackled in ocean research are part of the key priorities of Horizon 2020 tackling societal challenges and citizens’ concerns today in the European Research agenda. The exhibition will be opened during the Italian European Semester 2014 in November in order to give a greater relevance to the project by involving representatives and policy makers at the highest level, and to enhance the European dimension of the event and to reinforce its visibility.

Keywords: public engagement in rri
VERsatile, ultra-stable, multi-coherent and compact microwave photonics SYsTems (VERSYT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: France
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-04-01
End date: 2015-03-31
Duration (months): 12.0
Total project cost (EUR): 105580.4
EU funding (EUR): 97966.0
Participants: 1
Project status: CLOSED

The purpose of the present "Proof of Concept" proposal is to investigate the commercial viability of versatile and compact microwave photonic modules generating high-purity microwave signals and multi-coherent lightwave carriers. These oscillators are expected to core microwave sources in aerospace engineering. Within the framework of our ERC StG project NEXTPHASE (NEXT generation of microwave PHotonic systems for AeroSpace Engineering) which started in November 2011, we had the objective to propose beyond-state-of-the art microwave sources for aerospace engineering applications. The first milestone of the project was the fabrication of millimetre-size whispering gallery mode-disk resonators with ultra-high quality factors. We have developed a unique design capability for such resonators, and we have been able to generate stable Kerr optical frequency combs after pumping them with a laser. The successful generation of such combs is the essential achievement that enables the possibility of commercial multi-coherent laser and microwave sources as described in the present “Proof of Concept” proposal. Our ultra-stable, multi-coherent system is able to generate signals in both the lightwave and microwave spectral ranges and is thereby a promising technological object for aerospace engineering and for other applications as well.

Keywords: 278616
‘Viking’ Biocontrol Solution (VIBES)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: France
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-09-01
End date: 2016-02-29
Duration (months): 18.0
Total project cost (EUR): 168224.3
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

As human population grows the challenge is to increase food production while protecting the environment. To increase yields per arable surfaces, pesticides are heavily used for crop protection, including against insect pests. However the ubiquitous use of chemical insecticides raise issues ranging from human health concerns to links with pollinating bee population decline. Upon societal demand, recent EU legislation changes now impose reductions in chemical inputs and the market share of organic food is increasing. However pests still continue to reduce crop yields. Altogether this is driving renewed interests for the development of alternative pesticides. Insect viruses have long been recognized as safe bio-insecticides, but their commercial development was held back by their relatively slow mode of action (typically 5 days) compared to chemical insecticides. While studying genomic adaptation by in vivo experimental evolution for the ERC funded GENOVIR project, we unexpectedly selected a fast killing baculovirus strain, that we called ‘Viking’. This virus kills all infected insect in the record time of one day. We believe Viking to be highly marketable. The aims of VIBES PoC project are to prove viral production could be scaled up, while a tailor made market study will identify the applications to target for commercialization.

Keywords: 206205
Targeting BMP4 and BMPR1a for imaging of esophageal adenocarcinoma (BMP4EAC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Netherlands
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-09-01
End date: 2016-02-29
Duration (months): 18.0
Total project cost (EUR): 165250.47
EU funding (EUR): 149840.0
Participants: 1
Project status: CLOSED

Within BMP4EAC we aim to investigate the commercial feasibility of our newly discovered and highly specific antibodies against BMP4 and one of its receptors, BMPR1a, for imaging applications in oncology. BMP4 and BMPR1a are highly expressed in esophageal adenocarcinoma (EAC) and other tumors as well as their metastases. The specificity, strong binding capacity, rapid clearance, high tissue penetration level, and flexibility of our antibodies is unprecedented and makes them highly suitable for in vivo imaging applications. The opportunity: The current methods for evaluation of disease stage consist of diverse modalities, including, CT and PET-CT scans, and ultrasonography. These techniques have major limitations to accurately detect metastasis and are inadequate for monitoring disease response. In the clinical setting we foresee applications of our proprietary technology in the non-invasive diagnosis of tumors and metastases with high expression of BMP4 and/or BMPR1a (e.g. EAC), identification of patients with high chance to respond to BMP4 inhibitors, follow tumor progression during treatment, and facilitated localization of small metastases during surgical treatment. Furthermore, the labeled antibodies can be used to investigate the efficacy of novel therapeutic agents by following tumor progression in animal models in a research setting. The project and expected outcomes: Within the ERC PoC we will explore the commercial feasibility by in vivo validation experiments as well as by performing essential research for the formulation of a business proposition, strengthening our IP position, and developing a sound business plan. These activities will result in a proposition package that will be used to present the commercial potential to investors and other strategic partners to attract funding after completion of the ERC PoC and potentially even initiate licensing and partnership deals.

Keywords: 282079
Exploring the diagnostics market for simple and fast point-of-care antibody detection (ABSENS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Proof of concept grants
Action type: Support for frontier research (ERC)
Countries involved: Netherlands
Call:  (ERC-2013-PoC, 2013)
Start date: 2014-09-01
End date: 2015-08-31
Duration (months): 12.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Antibody detection assays are used in many fields of biomedicine including the diagnosis of infectious diseases, autoimmune diseases and allergies. Current analytical techniques for antibody detection come with intrinsic limitations such as the requirement for multiple time-consuming incubation steps, multiple reagents, and/or sophisticated equipment. Supported by an ERC consolidator grant we have developed a highly modular sensor concept for antibody-responsive reporter enzymes (AbSens) that addresses many of these challenges. Key advantages include the ability to monitor antibodies directly in solution, easy read-out based on a simple color reaction, adaptability to target any antibody of interest, and high affinity and specificity. We believe that this generic sensor platform could find applications in low-cost point-of-care diagnostics, clinical research, and the development of therapeutic antibodies. The goal of AbSens is to identify those opportunities in the huge market of antibody-based diagnostics where our sensor platform provides unique advantages over existing technologies, both in terms of analytical performance and economics. To enable the next step towards commercialization, the analytical performance of our technology will be compared to current gold standards using relevant clinical samples in collaboration with commercial parties and clinicians. Other commercially important parameters are the long-term stability of the assay components and the development of a yeast-based production system to lower the cost of enzyme production. Based on an in-depth market analysis and the feedback we receive from external stakeholders on the performance of our technology, a realistic strategy will be developed for the further commercialization. In anticipation of exploring the commercialization of our AbSens technology we filed a US provisional patent application in Sept. 2012 on the key underlying technology, which was recently continued via the PCT route.

Keywords: 280255
Power cable modelling for WIPS electromechanical chain (MULTYCAB)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Spain
Call:  (SP1-JTI-CS-2013-02, 2013)
Start date: 2014-08-01
End date: 2016-01-31
Duration (months): 18.0
Total project cost (EUR): 287594.78
EU funding (EUR): 215621.09
Participants: 1
Project status: CLOSED

The Multi Layer Cable Model MultiCaB project proposal aims to research and develop advanced parametric power cable models for aeronautical applications, specifically, thermo electric Wing Ice Protection Systems, WIPS. Apart from basic voltage and current analysis, models must allow to simulate and study high frequency effects, such as skin and proximity effects, standing waves and resonances, conductive and isolation losses and temperature effects. Two different layers of the model, which are related to result accuracy and computational burden, are considered in the project. To implement the model it is proposed a lumped parameters based model, which are frequency dependents, that must replicate the frequency response of the full cable for all the frequencies of interest. It means that not only the fundamental frequency have be taken into account in the model simulation, but also harmonics, switching frequency and high frequencies due to trise and tfall at the power converter must be considered for the complete results. A specific research in cable models and high frequency effects, a powerful methodology based on experimental measurements and if proceed, FEM simulations, and experimental validation of developed models and methodologies will be performed in the project. A proper management, a well-defined topic manager relationship and an adequate consideration of intellectual property rights and exploitation are included in the proposal. The project is presented by researches and technicians from the MCIA Research Center of Universitat Politècnica de Catalunya (www.mcia.upc.edu), with probed experience in high frequency modeling of electric and electronics components and power electronics applications and control, as well as in European projects' management and execution.

Keywords: thermo electric wips,high frequency cable modeling,lumped parameters cable model,skin and proximity effects,standing waves in power cables,pwm power delivering.
Failure analysis and damage mechanisms of newly developed, gamma-prime strengthened Ni - based superalloy (FAMEC)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Poland,Sweden
Call:  (SP1-JTI-CS-2013-02, 2013)
Start date: 2014-05-01
End date: 2016-09-30
Duration (months): 29.0
Total project cost (EUR): 600000.0
EU funding (EUR): 449998.0
Participants: 3
Project status: CLOSED

Reduction of the fuel consumption and emission of NOX and CO2 by jet engines is a priority of the ACARE SRA 2020 objectives. The development of an environmentally friendly aircraft engine (SAGE1) considers using lightweight and efficient turbine components. Within the objectives of open rotor development in SAGE1, activities are underway to develop new technologies for rotating structures. The rotating structure transmits the torque generated by the engine to the propellersand is subjected to the high temperature exhaust gas from the turbine. It is likely that frames will be made as a weld assembly consisting of cast parts in a newly developed y’ strengthened nickel based superalloy. However, it is a challenge to cast these alloys because they were primarily developed in wrought form. Currently, cast versions of low content y’ strengthened Ni alloys are widely investigated however failure analysis and damage mechanisms are not fully explored. Thus the aim of this project is to complex failure analysis of new alloy which is an enabler material for manufacture turbine components exposed at high temperature. In order to conduct a comprehensive investigation of damage mechanism the following objectives have been defined: a) optimizing the casting process parameters and heat treatment of alloy for a range of microstructures, b) experimental studies of mechanical behavior of newly developed alloy with different grain size under different loading and temperature regimes during monotonous and fatigue tests, c) determination and characterisation of damage mechanisms by advanced microstructural characterisation techniques. The consortium consists of technical university (WUT) and two certified, modern research centres equipped with unique devices providing high quality testing services, which offer new solutions to contemporary aviation (IoA and KIMAB). Such a structured consortium will provide complex expertise abilities of basic research studies and experimental trials.

Keywords: sage1,turbine structures,ni-based superalloy,failure analysis
Airline TriAls of Environmental Green flIght maNAgement functions (ATAEGINA)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Spain,Portugal,France
Call:  (SP1-JTI-CS-2013-02, 2013)
Start date: 2014-05-12
End date: 2016-09-11
Duration (months): 28.0
Total project cost (EUR): 1280295.4
EU funding (EUR): 836621.5
Participants: 5
Project status: CLOSED

Aiming at developing systems which enable environmentally sustainable flight operations, SGO part of the Clean Sky is working on the implementation of three new operational concepts suitable of being implemented on board through future Flight Management functions. Based on promising results through Laboratory test, ATAEGINA project should contribute to evaluate those concepts on a real operational environment by involving an Airbus equipped airline to: - Analyze the new proposed Flight Management functions and their compatibility with actual operations - Assess the environmental performance of those new functions, in comparison with actual operations, throughout an operational test plan and corresponding statistical analysis

Keywords: flight management,functions,noise,emissions,environment,trials