Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Flexible nanowire devices for energy harvesting (Nano Harvest)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: France
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2021-03-31
Duration (months): 72.0
Total project cost (EUR): 1496571.25
EU funding (EUR): 1496571.25
Participants: 1
Project status: CLOSED

The goal of NanoHarvest is to explore novel solutions for flexible photovoltaic and piezoelectric converters enabled by semiconductor nanowires. The first objective is to demonstrate an innovative concept of flexible solar cells based on free-standing polymer-embedded nanowires which can be applied to almost any supporting material such as plastic, metal foil or even fabrics. The second objective it to develop high-efficiency flexible and compact piezo-generators based on ordered arrays of nanowire heterostructures. The crucial ingredient - and also the common basis - of the two proposed research axes are the advanced nanowire heterostructures: we will develop nanowires with new control-by-design functionalities by engineering their structure at the nanoscale. The main focus of NanoHarvest will be on the III-nitride semiconductors, which are characterized by a strong piezoelectric response and have also demonstrated their ability for efficient photon harvesting in the blue and green parts of the solar spectrum. Our strategy is to address the physical mechanisms governing the energy conversion from the single nanowire level up to the macroscopic device level. The deep understanding gained at the nanoscale will guide the optimization of the device architecture, of the material growth and of the fabrication process. We will make use of Molecular Beam Epitaxy to achieve ultimate control over the nanowire morphology and composition and to produce control-by-design model systems for fundamental studies and for exploration of device physics. The original transfer procedure of the ordered nanowire arrays onto flexible substrates will enable lightweight flexible devices with ultimate performance, which will serve as energy harvesters for nomad applications.

Keywords: semiconductor nanowires,molecular beam epitaxy,energy harvesting,nitride semiconductors,nanoscale characterization,flexible devices,nanowire multi junction solar cell,nanowire piezogenerator
Quantum spin Hall insulator with two dimensional crystals (HELICOMBX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Dissipationless electrical transport is a key paradigm to reduce energy consumption in our society. Recent advancements in condensed matter physics have revealed that there exist ballistic transport channels at the surface or the edge of topological insulators. These states are preserved by time-reversal symmetry and robust against back scattering. Exploiting topological insulators is therefore a major step for future nondissipative nanoelectronics. Nevertheless, such a topological phase of matter has been discovered in very few kinds of materials so far. Most of the existing materials are difficult to fabricate, which limits scientific endeavor to explore their properties and also future application. Recently, several theoretical studies have demonstrated that atomically thin graphene or other two dimensional crystals may become two dimensional topological insulators (quantum spin Hall insulators) by inducing large spin-orbit interaction. These materials are rich of novel physics and attract growing attention in their own right. Moreover, they are easy to prepare by mechanical exfoliation, which facilitates to apply them to real nanoelectronics devices. HELICOMBX is the first project which aims at establishing a basis for dissipationless electronics and spintronics with graphene and transition metal dichalcogenides and unifying physics in topological phase, spintronics and two dimensional crystals. The project is divided into three parts. First we will induce large spin-orbit interaction in graphene by adatoms deposition and heterostructures construction with transition metal dichalcogenides. Spin-orbit interaction of each system is then measured by magnetotransport measurements. Second we will exploit these functionalized two dimensional crystals for spintronics devices. As the final part, quantized conductance will be measured as a signature of the edge states, and we will integrate it into Josephson junctions to observe the Majorana fermions.

Keywords: topological insulator,quantum spin hall insulator,graphene,transition metal dichalcogenide,heterostructure,adatom
Solupore® - Enabling the Manufacture of Affordable New Treatments to Cure Cancer (SOLUPORE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 2988750.0
EU funding (EUR): 2092125.0
Participants: 1
Project status: CLOSED

There is encouraging news for cancer patients, a new treatment, cell immunotherapy, has been delivering spectacular clinical results and is a game changer because it is an entirely new way of treating cancer. Cancer immunotherapy, in which a patient’s own immune cells are ‘armed’ by cell engineering to target and kill cancer cells, gives levels of complete response in patients. The first cell immunotherapy drug was approved in August 2017 at a price of $475,000 per treatment. To bring these life-changing treatments to patients and relieve the European and global healthcare burden they must become available at affordable costs. The one thing worse than failure is unaffordable success and the challenge with these treatments is the complex and high-cost of manufacturing. Current cell engineering methods are very expensive to manufacture. Avectas has developed Solupore, a cell engineering technology, which delivers cargo to cells and plays a critical role in the manufacturing process. The technology works by temporarily making the cell membrane permeable and allowing cargo into the cell. Crucially, cell health and functionality are preserved while there is a significant improvement on the process time and costs. Avectas has demonstrated that the pilot system can successfully deliver clinically relevant cargo to T cells. During this project, Avectas will scale and align Solupore to regulatory compliance enabling us to commercialise it. The emerging and fast-growing cell immunotherapy market is set to be worth $20bn in 2020, with cell manufacturing representing $5bn. Commercialisation of Solupore will take 1% of the €5bn market share by 2024 and will generate global revenues for Avectas, building value for the company and creating highly skilled jobs which will result in a high-value, knowledge-based EU company. There will be substantial European and global socio-economic impact on cancer patients living longer, better quality lives.

Keywords: cell therapy,immunotherapy,t cells,transfection,cell engineering car t,immunology
Untranslatable Modernity: Modern Literary Theory from Europe to Iran (TRANSMODERN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-07
End date: 2021-08-06
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

It is widely accepted that the advent of modernist Persian literary theory, its transformation from traditional Persian rhetoric (balagha) into modern criticism (qeritiqa) in the mid-nineteenth century, has been driven by translation and adaptation of European literary critical norms. While the central role of translation in importing and transmitting critical norms has been emphasized in the studies of the evolution of modern Persian literary theory, these studies usually take translation for granted without noticing that a major part of this literary and critical modernity has been shaped around the challenges of untranslatability. TRANSMODERN will innovatively theorize the shaping of modern Persian literary criticism around untranslatability through a close study of a wide range of Persian publications in literary criticism, from 1860s to 2000s. This will permit an understanding of how European critical norms affected Iranian literary systems and how the adaptation of these norms to a radically different non-European poetics transforms the way we think about and experience the literary form. TRANSMODERN will deploy and combine methods of archival research, translation methodologies and comparative qualitative and quantitative analysis. The main outputs will be three peer-reviewed articles, a critical monograph and academic and public presentations.

Keywords: untranslatability
TURNKEY solution for home RETROFITting (TURNKEY RETROFIT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Spain,Ireland,Ireland,Spain,Belgium,France,France,France,France
Call: Integrated home renovation services (H2020-LC-SC3-EE-2018, 2018)
Start date: 2019-06-01
End date: 2022-02-28
Duration (months): 33.0
Total project cost (EUR): 1499920.0
EU funding (EUR): 1499920.0
Participants: 9
Project status: CLOSED

Leveraging on the business operations of consortium partners (4000 integrated building renovations conducted to date), TURNKEY RETROFIT will develop and replicate an integrated home renovation service which will be initially operated in 3 EU countries - France, Ireland and Spain - with an expected 335M€ investment pipeline for home renovation within the first 5 years (approximately 14 700 dwellings renovated, leading to 96,6 GWh/year Primary energy savings triggered) beyond the end of the project. The project will point to further replication across Europe and Internationally in particular via the Green Building Council network. The TURNKEY RETROFIT service will be developed as a home-owner-centric renovation journey, which will transform the complex and fragmented renovation process into a simple, straightforward and attractive process for the home-owner. It will include the initial technical and behavioural diagnosis, technical offer, contract development and agreement, structuring and provision of financial support, as well as the on-site coordination of works and quality assurance. It will be a service-oriented model where the home-owner is offered tailor-made solutions through the whole customer journey. The service will be accessible through a user-friendly digital platform and it will address drivers of building renovation that go beyond a desire to reduce energy bills and increase asset value, such as home improvement, increased comfort, enhanced health & quality of life.

Keywords: integrated home renovation service
Development of a novel genetically engineered mouse model to study the role of HDAC6 in oncogenesis and metastasis of non-small cell lung cancer. (HDAC6_GEMM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,United States
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2021-09-30
Duration (months): 36.0
Total project cost (EUR): 248063.4
EU funding (EUR): 248063.4
Participants: 2
Project status: CLOSED

Lung cancer is a leading cause of cancer deaths in Europe. Non small cell lung cancer (NSCLC) accounts for nearly 85% of all cases of lung cancer with a five year survival rate of 15%. Novel targeted therapies are urgently needed to overcome drug resistance and prevent tumour recurrence. The host supervisor carried out a small molecule screen to identify therapeutics for the treatment of drug-resistant NSCLC. A novel specific inhibitor of histone deacetylase 6 (HDAC6) was discovered. The molecular mechanisms of HDAC6's role in cancer is beginning to be elucidated however, this task is made difficult due to the lack of a specific inhibitor. The overall research aim of this proposal is to understand the molecular mechanisms of HDAC6 in the tumour initiation and progression of NSCLC. To do this, I will develop a unique state-of-the-art conditional genetic mouse model of NSCLC in which HDAC6 is knocked out. I will do this work in the laboratory of Prof. Wong at New York University, an expert in conditional genetic mouse models. I will study the role of HDAC6 on the immune-microenvironment of the lung tumours using multi-parameter flow cytometry and single cell RNA-sequencing. Upon re-integration to the host laboratory I will establish the HDAC6 knockout NSCLC mouse model. Lastly, I will assess the efficacy of the novel HDAC6 inhibitor on tumour progression compared to the mouse model. This project has the potential to contribute greatly to our understanding of the role of HDAC6 in NSCLC and lead to the discovery of targeted therapeutic. Through this prestigious fellowship I will diversify my research skill-set, I will gain international experience in a world-leading laboratory of NSCLC and I will be excellently positioned to develop my independent research career on return to Europe.

Keywords: conditional genetic mouse models,cell ceath,tumour microenvironment,hdacs
Topological states with Spin-Dependent potentials for ultracold lithium (TopSpiD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-07-01
End date: 2020-06-30
Duration (months): 24.0
Total project cost (EUR): 175419.6
EU funding (EUR): 175419.6
Participants: 1
Project status: CLOSED

The recent understanding of the topological properties of matter has led to the search for the experimental production and control of topological excitations such as Majorana fermions. They appear at the boundary between a topological superconductor and a normal metal and have intriguing properties such as non-abelian exchange statistics and insensitivity to decoherence. Their production would give an invaluable insight on the properties of topological phases of matter as well as paving the way towards fault-tolerant quantum computing. The aim of this action is to create them in an ultracold atom set-up which is a ideal platform to engineer interesting Hamiltonians. We propose to create such excitations by combining effective spin-orbit coupling with superfluid properties. We will use near-resonant light which has led to the successful implementation of artificial magnetic fields and spin-orbit coupling in ultracold atoms. We want to produce the latter coupling while limiting the associated heating due to spontaneous emission: the key idea is to shine the near-resonant beams on a very small region, where spontaneous emission leads to losses but not to heating. We already have an apparatus able to realize the atomic equivalent of a quantum point contact. In this project, the experienced researcher, already expert in ultracold atom techniques, will lead the experimental team effort. As intermediate results, we will study the flow of atoms through “atomtronics” light structures, implement a cooling scheme using such an atomtronic device and understand the effect of increased losses in the channel on transport. The combination of these new potentials with superfluid behaviour for ultracold atoms leads to the implementation of the Kitaev model that bears the highly sought Majorana excitations, and detection will take advantage of easily accessible transport observables. The atomtronics techniques developed would open wide perspectives for future studies.

Keywords: degenerate fermi gases,topological excitations,atomtronics,quantum transport,majorana fermions
Multisensory signal processing: From brain-wide neuronal circuits to behavior (MultiSense)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2023-08-31
Duration (months): 78.0
Total project cost (EUR): 1371250.0
EU funding (EUR): 1371250.0
Participants: 2
Project status: SIGNED

Our brain needs to constantly fuse sensory information detected by our multiple senses in order to produce a seamless coherent representation of the world. Rather than being the exception, this binding process is ubiquitous to sensory-motor integration and is implicated in most cognitive functions. Its impairment is a cause of various pathologies, such as schizophrenia or autism. Multisensory processing operates on all brain levels from primary cortices over subcortical structures up to higher associative centers, while the smallest operational units are single multisensory neurons. In an interdisciplinary effort, we combine optical developments, genetics and neuro-computation to obtain new insights into the activity of brain-wide neural circuits that process multisensory information. To reduce the complexity, we study the small transparent brain of zebrafish larvae as a model system. We focus on gaze stabilization as an inherently multisensory model task that is conserved among all vertebrates. This reflex uses both vestibular and visual information to drive eye movements in order to compensate for self-motion and maintain clear vision. We will build a novel experimental platform in which a restrained larva will be submitted to vestibular and visual stimuli, as a pilot in a flight simulator. We will optically record the activity of all 100,000 neurons of the animal brain as it performs multisensory integration tasks. To extract basic principles of how behavior is coded in multisensory neuronal circuits we will interpret the brain-wide activity and the observed behavior with methods from statistical physics. No other system can today provide a similar brain-scale, yet cell-resolved view on the neuronal network dynamics subserving such a complex integration process. Thus, our data will constitute an invaluable arena to test circuit-based models for sensory-motor integration, decision-making and multisensory-motor learning.

Keywords: multisensory integration,functional whole brain imaging,calcium imaging,motor learning,bayesian inference,zebrafish,neuronal network modeling,sensory motor integration,optogenetics
European Training Network for the remediation and reprocessing of sulfidic mining waste sites (SULTAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Germany,Germany,Spain,Switzerland,Finland,Belgium,Finland,Belgium,Belgium,Netherlands,Portugal,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2018-09-01
End date: 2022-08-31
Duration (months): 48.0
Total project cost (EUR): 3910958.64
EU funding (EUR): 3910958.64
Participants: 15
Project status: CLOSED

For more than 100 years the EU mining industries have been discarding their extractive-waste residues. Estimates suggest this represents 29% of the EU-28’s current waste output. When poorly managed these residues are a significant environmental hazard. Sulfidic Cu-Zn, Zn-Pb and Cu-Zn-Pb tailings pose the largest challenge, as they are prone to acid mine drainage. However, these tailings also contain valuable metals. Recently, the EIP Raw Materials launched a “call to arms” to transform the “extractive-waste problem” into a “resource-recovery opportunity”. Additionally, the EIP has warned about the acute shortage of talent in this sector. In order to develop a highly skilled work force, to mitigate environmental risks and to economically recover valuable raw materials, the ETN for the remediation and reprocessing of sulfidic mining waste sites (SULTAN) provides the first-ever training programme dedicated to the reprocessing of tailings. SULTAN has pooled the interdisciplinary and intersectoral expertise of leading EIT RawMaterials members, world-leading mining and chemical companies, covering all links in the tailings-reprocessing value chain. SULTAN develops cutting-edge methodologies to assess the resource potential of Europe’s main tailings families (WP1) and explores eco-friendly mining chemicals for advanced metal-extraction/recovery set-ups (WP2). SULTAN not only recovers the metals but also valorises the clean(ed) tailing residues in circular-economy applications, incl. inorganic polymers, green cements and ceramics (WP3). In WP4 a novel environmental assessment methodology is developed. The 15 SULTAN ESRs benefit from a unique soft-skills training programme (WP5) and maximise the impact of their research through dissemination & exploitation (WP6). This kick-starts their careers as highly employable professionals in the EU’s tailings reprocessing/remediation sector, as well as for geological surveys, teaching and scientific organisations, and public bodies.

Keywords: extractive waste,tailings,geology,geometallurgy,organic synthesis,mineral processing,biometallurgy,solvometallurgy,hydrometallurgy,ceramics,inorganic polymers,scms