Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
NANODELIVERY OF SPECIFIC GENOME ENGINEERING TOOLS AS A NOVEL THERAPEUTIC APPROACH FOR AGGRESSIVE PROSTATE CANCERS (NANOCRISPR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-11
End date: 2023-01-10
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Prostate cancer is the second most common diagnosed malignancy and the fifth leading cause of cancer mortality in men. Whilst primary tumours respond well to therapy, tumours in the metastatic setting become inherently resistant to chemotherapy. Thus, more novel and effective therapeutic approaches are highly needed to treat this lethal disease. The cornerstone treatment for advanced prostate cancer consists of androgen deprivation therapy and docetaxel (DTX). However, both DTX activity and Androgen receptor (AR) signalling are highly interrelated. On the one hand, it has been shown that DTX is able to inhibit Androgen Receptor (AR) signalling and on the other hand, the activation of AR signaling can induce DTX insensitivity. In order to break this dependency of DTX effectiveness on AR signaling and ensure efficient treatment for advanced prostate cancer, we propose the selective inhibition of AR deploying CRISPR/Cas9 technology together with DTX. Both therapeutical approaches will be encapsulated into prostate-specific targeted nanoparticles which will allow the simultaneous delivery of the drug and CRISPR plasmids targeting AR into the tumour site. The designed state-of-art multi-functional nanoparticles will reprogram and sensitise the prostate tumour to DTX in situ, and will also induce a higher accumulation of the treatment in the tumour while healthy tissues will remain less affected. Moreover, the use of CRISPR/Cas9 will precisely engineer the prostate cancer cells to express lower levels of AR, contrasting with current anti-AR treatments, which have multiple off-targets. This approach represents an innovative targeted therapy for advanced prostate cancer. It will allow the administration of lower doses of chemotherapy with consequently reduced toxicity and the potential for longer tolerated treatment periods, whilst improving efficacy by selectively suppressing the molecular pathways causing cancer survival and resistance to treatment.
Ill-health, Work and Occupational Health in Early Modern Italy (ca.1550-1750) (Occupational Health)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2023-09-30
Duration (months): 36.0
Total project cost (EUR): 257209.92
EU funding (EUR): 257209.92
Participants: 1
Project status: SIGNED

My project investigates the relationship between ill-health and working life in early modern Italy (c.1550-1750). The objective is to analyse how workers communicated health problems to employers and, in turn, how employers responded. It provides a ground-breaking perspective on the cultural history of ill-health, taking an occupational health approach to experiences of illness, health in the domestic environment, and public health. Ill-health is broadly conceived, encompassing chronic illness, bouts of ill-health, and injury. Work is defined as ‘the use of time with the goal of making a living.’ Therefore, both paid and unpaid activities are considered, and particular attention is given to women’s work. Italy is a crucial site for analysis as it had a diverse workforce in highly urbanised areas while also being at the forefront of developing public health procedures in Europe, including the regulation of dangerous jobs. Concerns about the health consequences of working practices grew during this period, as demonstrated by a widely circulated treatise on the diseases of workers first published in 1700. I will apply methodological approaches from the history of epistemology to neglected sources including manuscript ‘sick notes’ found in letters, physicians’ notebooks, medical treatises, and regulations created by employers. The project examines how concerns about work activities were integrated into medical discourse and diagnosis, how workers understood and shared health problems, and how occupational health shaped early modern society. Following teaching-focused positions and non-academic employment, I will restart my research career at Ca’ Foscari in Venice where I will have access to archives, work with outstanding researchers and receive career development training. The results will be disseminated through peer-reviewed, open access journals, a project website, a museum exhibition and via academic and public talks.

Keywords: ill health,work,occupational health,medical epistemology,venice,mantua,early modern europe
Upscale and redesign of a mobile harvesting and pelletizing disruptive all-in-one machine (HarvPell)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Austria
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-03-01
End date: 2017-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The EU is setting ambitious targets in terms of energy coverage by renewable energies with their 20-20-20 goals. Biomass is a major column to achieve these goals, but until 2020 a gap of 24-40Megatons of biomass was detected . In biomass plants pellets can be burned and heat and / or electricity for further use can be produced. Pellet production is becoming a world market with Europe as a central player as within EU27 countries 50% of the pellets are produced and 70% are consumed (11 and 15.1 million tons per year respectively). Producing pellets is a various step process, which includes works on the field (mowing, collecting), transportation and pelletizing. Mobile pelletizers have been brought to the market by Agro Bio Tech, PCM Green Energy or Bauer and Krone has planned one for 2018 but none of the competitor products offers an all-in-one solution, which integrates all necessary steps for producing pellets from the field to ready to use pellets (figure 1). SCM will revolutionize the market by offering a self-driving all-in-one machine, our PELLESTER, that unifies all necessary process steps for harvesting and pelletizing: - The PELLESTER reduces transportation cost for pre-pelletizing by 100%; - It provides a 1 to 16 times higher throughput than that offered by competitors; - Specific pelletizing cost are less than 25€/t (>70% lower than competing systems); - It comprises a remote control, high level of automization and advanced self-learning software. SCM will provide farmers, farm cooperatives and machinery contractors with our PELLESTER a mobile harvester that enables cost-efficient pellet production in a single operation directly in the field. This project, HarvPell, will directly create 57.5million € and 115 new jobs until 2022.

Keywords: biomass,pellets,mobile harvester
EUCAlyptus LIgnin VAlorisation for Advanced Materials and Carbon Fibres (EUCALIVA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Innovation actions
Partnership: BBI (Art-187)
Countries involved: Germany,Spain,Italy,Italy,Spain,Finland
Call: Valorisation of lignin and other side-streams to increase efficiency of biorefineries and increase sustainability of the whole value chain (H2020-BBI-JTI-2016, 2016)
Start date: 2017-09-01
End date: 2021-07-31
Duration (months): 47.0
Total project cost (EUR): 2419871.25
EU funding (EUR): 1795009.88
Participants: 7
Project status: CLOSED

Natural resources are being exhausted due to the great demand of their services and the insufficient actions taken for their preservation. Against this background, the use of waste components from industrial activities as raw materials to obtain high value-added products is of great relevance. Lignin from pulping process is present all over Europe and represents a big source of underexploited material. There is an estimated 70 million tonnes of lignin available from pulping processes worldwide, but much of this is not isolated but burned onsite to provide steam for heat and power production. Until now only about 2% of the lignins available in the pulp and paper industry is commercially used comprising of about 1,000,000 tons/year lignosulphonates originating from sulphite pulping and 104,000 tons/year of kraft lignins produced in the kraft process

Keywords: lignin,carbon fibres,elctrospinning
Decolonising madness? Transcultural psychiatry, international order and the birth of a global psyche in the aftermath of the Second World War (DECOLMAD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-08-01
End date: 2025-07-31
Duration (months): 60.0
Total project cost (EUR): 1499952.0
EU funding (EUR): 1499952.0
Participants: 1
Project status: SIGNED

This project will provide crucial insights into the debate on the universality and cross-cultural applications of the notions of mental health and illness by offering the first and inter-disciplinary account of the historical origins and development of the concept of ‘global psyche’ and transcultural psychiatry. It will offer the first historical analysis of the colonial and post-colonial roots of the current global mental health movement, and the first systematic account of the decolonisation of psychiatry and mental health sciences. It will argue that the concept of universal, global psyche emerged in the aftermath of WWII and during decolonisation, when Western psychiatry strove to leave behind its colonial legacies, and lay the foundation for a more inclusive conversation between Western and non-Western mental health communities. In this period, leading psychiatrists across the globe set about identifying and defining the universal psychological mechanisms supposedly shared among all cultures (and 'civilisations'). I will explore this far-reaching psychiatric, social and cultural search for a new definition of 'common humanity', which developed in an increasingly inter-connected and culturally diverse global context, and examine the historical forces that drove it. I will also examine how the profession negotiated the tensions between researching cultural particularities and developing new, cross-cultural models of the mind. The project will answer some of the core questions related to this transformative period: How did psychiatrists and anthropologists from all over the world re-define the relationship between culture, race and individual psyche following the end of the Second World War and colonialism, what was the role of experts from the Global South and Eastern Europe in this transformative process, and did this new global and transcultural psychiatry succeed in departing from the erstwhile colonial frameworks?

Keywords: history of psychiatry and mental health,decolonisation,transcultural psychiatry,global peripheries,patients voices
Medicine, Heresy and Freedom of Thought in sixteenth-century Italy: a Network of Dissident Physicians in the Confessional Age (netdis)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 164203.8
EU funding (EUR): 164203.8
Participants: 2
Project status: CLOSED

I am an expert researcher on the religious and medical history of sixteenth-century Italy. Applying for a GF, supervised by professors Findlen - at Stanford - and Barbierato - at the Univr-, I will examine and interpret the link between sixteenth-century heretical thought and the rise of modern science, exploring the local, national and trans-national levels of this connection. NETDIS will use digital humanities tools to reveal the network of Italian physicians who developed non-conformist religious views. By exploring the nature, extent and function of the ties among physicians, NETDIS will inquire into the genesis of freedom of thought - which stands today at the core of European identity - as an embryonic value shared by most physicians in response to the spread of intolerance in the confessional age. This will have a positive insights for several ongoing difficulties facing the EU, such as the revival of religious violence (i.e. terrorism). Working on NETDIS I will learn innovative methodologies; I will gain new perspectives for an international career; I will write my first monograph.

Keywords: history of ideas,history of the reformation,history of medicine,early modern history,history of sixteenth century italy
Advanced Atmospheric Carbon Capture Technology (AACCT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Ireland
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Ever increasing atmospheric CO2 concentrations and global emissions of 36 Gt/year impose unprecedented threats to the world’s ecosystem and endanger industrial human activities in their entirety. This AACCT project will establish a new advanced technology that facilitates efficient CO2 capture from air and results in a commercial, stand-alone prototype that will demonstrate its economical and ecological viability, outperforming all other emerging approaches to atmospheric CO2 capture. The technology takes advantage of unique, intrinsic micro- and macro-molecular structures of porous materials that were developed within the ERC SUPRAMOL and Science Foundation Ireland funded projects. These adsorbents reveal extraordinary affinity to CO2, are non-corrosive, non-toxic and are based on stable, cheap and abundant silica materials. The system operates in moist air whereby the CO2 recovery is facilitated at mild conditions under which the adsorbent is regenerated. These intrinsic characteristics in combination with the macro-structure of sub-millimetre pellets that enhances the ad/desorption kinetics, results in exceptionally low operational CO2 capture costs. The technology is modular and the number of capture units scales linearly with the desired CO2 quantity. It is not restricted to fixed locations or CO2 point sources and thus, can conceptionally lead to negative or net zero CO2 emissions. The AACCT technology will provide pure CO2 that can be sold, used or transformed within established or emerging chemical processes (i.e. methanol synthesis). Initially, it is envisaged that the systems, using low-grade waste heat, will be employed in energy-intensive industrial sectors requiring air circulation and cooling devices. A very modest adaptation of the AACCT prototypes can facilitate the reduction of Ireland’s greenhouse gas emissions by >10%, thus highlighting the potential impact and scalability of the proposed technology at European and global levels.

Keywords: porous materials,co2 capture,materials science,chemical engineering,synthetic chemistry
Understanding and Controlling Glycosylation Reactions (GLYCONTROL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-05-01
End date: 2022-10-31
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

This proposal aims to understand and control glycosylation reactions. In a glycosylation reaction a “donor” glycoside and an “acceptor” (the nucleophile) are united to form an oligosaccharide. Although it is the central reaction in carbohydrate chemistry, our understanding of this reaction, in terms of stereoselectivity and productivity is still limited. The structural variation in the building blocks leads to a complex continuum of SN2-SN1 mechanisms that operates and it is currently impossible to predict where in the continuum the reaction exactly takes place. This proposal provides fundamental insight into the outcome of glycosylations by studying both the activated donor glycoside and the acceptor nucleophile. Activation of a donor glycoside leads to different reactive intermediates, covalent anomeric species (most often triflates) and oxocarbenium ion-like species. The relative reactivity of these species is quantified to generate novel reactivity charts. The covalent species are studied by innovative competition experiments, kinetic studies and NMR spectroscopy. The (fleeting) oxocarbenium ion-like intermediates are probed by a computational approach and by “super-acid NMR” studies in which stable glycosyl cations are generated and studied in super-acid media. The reactivity of glycosyl acceptors is systematically studied in a set of SN2 or SN1-type glycosylations. Using kinetic studies and competition reactions charts of acceptor nucleophilicity are compiled. The reactivity of the donors and acceptors is matched using a family of tailor made “reactivity modulators”, spanning a broad reactivity window bridging the reactivity gap between the building blocks leading to predictable glycosylations. The developed methodology is employed in automated solid phase syntheses of libraries of oligosaccharides featuring multiple cis-glycosidic linkages. The proposal is a major step forward in the development of a general glycosylation procedure.

Keywords: carbohydrates,glycosylations,oligosaccharides,reaction mechanism,stereoselectivity,automated synthesis
Nanomaterials for conservation of European architectural heritage developed by research on characteristic lithotypes (NANO-CATHEDRAL)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Materials for creative industries, including heritage
Action type: Innovation actions
Countries involved: Germany,Spain,Italy,Italy,Austria,Germany,Italy,Germany,Italy,Germany,Spain,Italy,Belgium,Norway
Call: Materials-based solutions for protection or preservation of European cultural heritage (H2020-NMP-2014-two-stage, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 6969176.38
EU funding (EUR): 6321335.68
Participants: 21
Project status: CLOSED

The project NANO-CATHEDRAL aims at developing, with a nano-metric scale approach, new materials, technologies and procedures for the conservation of deteriorated stones in monumental buildings and cathedrals and high value contemporary architecture, with a particular emphasis on the preservation of the originality and specificity of materials. The objective is providing “key tools” for restoration and conservation: •On representative lithotypes •On European representative climatic areas •With a time-scale/environmental approach •With technology validated in relevant environment (industrial plant and monuments) •Exploiting results also on modern stone made buildings A general protocol will be defined for the identification of the petrographic and mineralogical features of the stone materials, the identification of the degradation patterns, the evaluation of the causes and mechanisms of alteration and degradation, including the correlations between the relevant state of decay and the actual microclimatic and air pollution conditions. Moreover, innovative nano-materials will be developed suitable for: •Surface consolidation: in this case water-based formulations based on nano-inorganic or nano-hybrid dispersions such as nano-silica, nano-titania, nano-hydroxyapatite, nano-calcite and nano-magnesia as well as their synergic combinations with organic and inorganic compounds will be considered. •Surface protection: in this case, innovative composites will be developed consisting of polymers and nano-fillers. The use of hydrophobins, nano-assembled hydrofobic proteins extracted from fungi, and photocatalytic nano-particles (for favoring the decomposition of volatile organic molecules carried by polluted atmosphere and to prevent biofilm growth) will be considered. The project will contribute to the development of transnational cultural tourism and to the development of common European shared values and heritage, thus stimulating a greater sense of European identity.

Keywords: nanotechnology,stones,durability,medieval and modern buildings,construction materials