Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Maintaining synaptic function for a healthy brain: Membrane trafficking and autophagy in neurodegeneration (RobustSynapses)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-01-01
End date: 2022-06-30
Duration (months): 78.0
Total project cost (EUR): 1999025.0
EU funding (EUR): 1999025.0
Participants: 1
Project status: CLOSED

Neurodegeneration is characterized by misfolded proteins and dysfunctional synapses. Synapses are often located very far away from their cell bodies and they must therefore largely independently cope with the unfolded, dysfunctional proteins that form as a result of synaptic activity and stress. My hypothesis is that synaptic terminals have adopted specific mechanisms to maintain robustness over their long lives and that these may become disrupted in neurodegenerative diseases. Recent evidence indicates an intriguing relationship between several Parkinson disease genes, synaptic vesicle trafficking and autophagy, providing an excellent entry point to study key molecular mechanisms and interactions in synaptic membrane trafficking and synaptic autophagy. We will use novel genome editing methodologies enabling fast in vivo structure-function studies in fruit flies and we will use differentiated human neurons to assess the conservation of mechanisms across evolution. In a complementary approach I also propose to capitalize on innovative in vitro liposome-based proteome-wide screening methods as well as in vivo genetic screens in fruit flies to find novel membrane-associated machines that mediate synaptic autophagy with the ultimate aim to reveal how these mechanisms regulate the maintenance of synaptic health. Our work not only has the capacity to uncover novel aspects in the regulation of presynaptic autophagy and function, but it will also reveal mechanisms of synaptic dysfunction in models of neuronal demise and open new research lines on mechanisms of synaptic plasticity.
CARBON ACCOUNTING IN THE FOREST-BASED INDUSTRY – MAXIMISING THE MITIGATION POTENTIAL OF WOOD PRODUCTS IN SLOVENIA (MAXIWOOD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Slovenia
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-05-01
End date: 2026-02-07
Duration (months): 36.0
Total project cost (EUR): 243060.48
EU funding (EUR): 243060.48
Participants: 1
Project status: SIGNED

Forest-based industries are responsible for about 3% of the world’s total CO 2 eq. emissions and represent one of the few readily available and effective ways of capturing atmosphere’s carbon dioxide. Restructuring forest industries towards products which offer the benefit of long-term carbon storage in so-called harvested wood products (HWP) has an important and underexplored mitigation effect for global warming. In Slovenia, forests represent 58 % of the landcover and are highly important ecologically, socially and economically. Despite the known carbon mitigation potential of wood and the high untapped harvesting capacity as well as the potential for a revival of wood industry, strategic documents do not address the importance of the forest industry as means of offsetting carbon emissions. In order to maximize the potential carbon sink effect of Slovenian forest industry, it is crucial to understand the product/resource interconnections within the value chain and where the carbon is stored/released. Making use and further upgrading candidates’ current skills in modelling and LCA, MAXIWOOD aims to analyse the CO 2 emitted and sequestered by the forest based industry in Slovenia through carbon sequestration, manufacturing, end-of-life treatment and substitution of other products. This will in facilitate an identification of the opportunities for the Slovenian forest industry to improve its carbon footprint and increase competitiveness. Existing national and international studies are largely based on 2013 IPCC guidelines for carbon accounting and are not sufficiently detailed to be translated into policy measures. MAXIWOOD will build further on the existing methodologies in order provide results detailed enough to inform effective policy making. The developed methodology will be applicable in other countries in Europe, increasing the competitiveness of the forest sector and mitigating global warming internationally.

Keywords: bioeconomy,forest based industry,wood products,carbon accounting,climate change mitigation
Modern spent fuel dissolution and chemistry in failed container conditions (DISCO)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Radioactive waste management
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Spain,Sweden,Switzerland,Belgium,Finland,Sweden,France,United Kingdom,United Kingdom,United Kingdom
Call: Addressing key priority R&I issues for the first-of-the-kind geological repositories (NFRP-2016-2017-1, 2016)
Start date: 2017-06-01
End date: 2021-11-30
Duration (months): 54.0
Total project cost (EUR): 4692067.5
EU funding (EUR): 3987675.5
Participants: 20
Project status: CLOSED

While the scientific understanding of the dissolution of standard spent uranium oxide fuel has reached a certain mature state, new types of fuels with additives (“doped fuels”) have been developed. These fuels are already in use in some reactors, and their use is foreseen to be expanded. Dissolution data is now required to confirm that the dissolution behaviour of such fuels in a geological repository environment is similar to that of standard fuel. Similarly, there is a dearth of dissolution data from MOX fuels, which are also currently in use in several reactors. This project is therefore targeting oxide fuels containing additives, including Cr, Gd and Pu, in order to ensure that relevant characteristics are understood to a level commensurate with standard fuels. This project aims to expand the database on spent fuel dissolution with results from dissolution studies performed in truly reducing conditions, with hydrogen present. The effects of dopants will be investigated through experiments using both spent nuclear fuel and synthetic materials specifically designed for the project. In addition, chemical modelling will be employed to improve the understanding and description of the dissolution process relevant to the expected chemical conditions inside a failed waste container in a deep geological repository environment.

Keywords: spent nuclear fuel,dissolution,chemical modelling
The formation of the Galaxy: constraints from globular clusters (GALFOR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Italy
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-10-01
End date: 2022-09-30
Duration (months): 60.0
Total project cost (EUR): 717246.0
EU funding (EUR): 717246.0
Participants: 1
Project status: CLOSED

For half a century, globular clusters (GCs) have been considered as prototype of simple stellar populations and their color-magnitude diagrams (CMDs) were believed to be the proxy of an isochrone. My research activity has resulted in one of the most exciting and unexpected developments in stellar-population studies in recent years: the discovery that the CMDs of many GCs are made of two or more intertwined sequences that can be followed continuously from the hydrogen-burning limit to the last stages of the stellar evolution. These findings, together with the discovery that multiple sequences correspond to distinct stellar populations with different helium abundance, have dramatically changed the traditional picture of these seemingly simple stellar systems. Among the open issues are the still-eluding second-parameter problem of the horizontal-branch morphology and the formation mechanisms that build the Galactic halo. Multiple populations may correspond to different generations of stars and prove that GCs, similarly to dwarf galaxies, have experienced a very complex star-formation history. As an alternative, they can be the product of exotic phenomena that have taken place in the proto-GC environment only. The Hubble-Space-Telescope archive is a golden mine to extend the innovative studies that I have introduced on a few objects to a large sample of hundreds clusters. The proposed research is based on this huge dataset, together with the data that Hubble is in process of collecting as part of my surveys of GCs. I will use the last-generation image analysis and spectroscopic techniques to derive the first atlas of multiple populations in the Milky Way and in Magellanic Cloud clusters, derive their helium abundance, investigate their chemical composition, spatial distribution and internal dynamics. In summary, I will trace the series of events that led from massive clouds in the early Universe to the GCs we see today, with their multiple populations.
Advancing Alternative Migration Governance (ADMIGOV)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Spain,Ethiopia,Türkiye,Belgium,Greece,Poland,Netherlands,Netherlands,Netherlands,Denmark,Denmark,Lebanon
Call: Towards forward-looking migration governance: addressing the challenges, assessing capacities and designing future strategies (H2020-SC6-MIGRATION-2018, 2018)
Start date: 2019-02-01
End date: 2023-01-31
Duration (months): 48.0
Total project cost (EUR): 2788870.0
EU funding (EUR): 2788870.0
Participants: 14
Project status: CLOSED

ADMIGOV aims to promote an alternative migration governance model. ADMIGOV takes seriously the principles laid out in the New York Declaration (NYD) and the Sustainable Development Goals (SDGs) to study how alternative approaches to migration governance can be better designed and put into practice. However, rather than proposing a top-down study of existing migration policies, ADMIGOV studies the reality of existing polices and practices on the ground to improve migration governance in line with the principles set out in the NYD and SDGs. This is the unique analytical feature of ADMIGOV. We bring together analyses of migration governance in practice and in key times and spaces and relate these analyses to the key structuring principles of migration governance as laid out in the NYD and SDGs. This is done to better understand the current gaps between principles and practices and in order to provide insights and recommendations for migration governance in the future. ADMIGOV is methodologically unique. We bring analyses from along the migration ‘chain’, from entry through to exit and incorporating key issues such as labour migration, protection needs and development goals. ADMIGOV has chosen several case studies of key times and spaces in migration governance, including the Greek islands, Lebanon, and Turkey, to better understand the most important and most problematic processes at play. Additionally, through the involvement of the Danish Refugee Council, ADMIGOV has access to possibly the largest dataset on migrants on the move today. The 4Mi data of the Danish Refugee Council will give ADMIGOV access to and help us generate more data than a single research team could normally collect. In short, ADMIGOV is designed to combine the analyses of existing policies and practices on the ground in key times and spaces with the wide-ranging 4Mi data to generate new indicators of good migration governance, helping the EU put the NYD and SDGs into practice.

Keywords: migration governance,development,protection,sdg s
New generation of porphyrinoids for mitochondria-targeted photodynamic therapy (PROMPT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

PROMPT will develop a new generation of photosensitizers targeting mitochondria in cancer cells, to be used in photodynamic therapy (PDT). The innovative approach of PROMPT is based on the design and synthesis of porphyrinoids functionalized with aromatic heterocyclic groups containing C-S bonds. These molecules are expected to localize specifically in mitochondria of cancer cells and to efficiently generate singlet oxygen, leading to apoptosis induction and cell death. Loading of the photosensitizers into liposomes ad hoc functionalized to target mitochondria is also envisaged in case of need. The innovative photodynamic treatment will thus show high selectivity, lower dose of treatment and reduced side effects with respect to the presently used phototherapy approaches. Moreover, the new molecules are expected to show significant two-photon absorption properties, due to the extended conjugation of the porphyrinoid core introduced by the aromatic side groups. They will thus represent a groundbreaking class of mitochondria-targeted photosensitizers for both one- and two-photon PDT. The multidisciplinarity of PROMPT, together with the proposed work plan in a forefront area of bio-medical research, will widen the scientific skills and technological know-how of the Experienced Researcher, significantly improving his career opportunities both in the academic and private sectors.

Keywords: porphyrinoids,mitochondria,photodynamic therapy,two photon absorption,organic synthesis
Non-invasive and accurate diagnosis and treatment of breast cancer. (BrEXo-Apt)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: CLOSED

Increasing evidences indicate that the release of a great numbers of exosomes by tumour cells play a key role in tumour progression, drug resistance, immune surveillance escape, angiogenesis, tumour invasion and metastasis. For this reason, cancer-derived exosomes are emerging as very interesting targets for cancer therapy and diagnosis. In particular, extracellular exosomes may have great potential as early diagnostic and prognostic biomarkers for many types of cancer, including breast cancer. Early screening methods for breast cancer are mainly based on instrumental tests, that may cause in many cases a failure to reach particular categories of patients. This failure could be overcome with the availability of specific and predictive circulating biomarkers allowing non-invasive earliest tumour detection on a larger scale of patients. Indeed, progresses in developing nucleic acids-based therapeutic compounds, including antisense DNAs, aptamers, short interfering/microRNAs, and short activator RNAs, have attracted great interest as emerging platforms for precise cancer treatment. Dr Quintavalle has identified aptamers that specifically recognize BC-released exosomes and are able to discriminate between breast cancer derived exosome and glioma or lung cancer derived exosomes. Preliminary data indicates also that these aptamers are able to block the internalization of MDA231 derived exosome on MDA231 cells. To develop a new diagnostic and therapeutic strategy, Dr Quintavalle will aim to exploit the identified aptamers to design an innovative aptamer-based sandwich assay for their specific detection in patient blood samples. Moreover, since the inhibition of cancer exosome uptake by surrounding healthy tissues and organs would represent an effective strategy to interfere with tumour spreading and development, Dr. Quintavalle will aim to generate an affinity plasmapheresis system by using BC specific aptamers for specifically remove BC-derived exosome from patient blood.

Keywords: aptamer,breast cancer,exosome,elisa,diagnosis,therapy,apheresis,blood,serum
Pathways Regulating Intramyocellular Insulin Sensitivity and Metabolism in Health and Disease (PRIISM-HD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom,Canada
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-04-01
End date: 2020-11-11
Duration (months): 36.0
Total project cost (EUR): 255349.8
EU funding (EUR): 255349.8
Participants: 2
Project status: CLOSED

Currently, there is an urgent need to understand the pathogenesis underpinning insulin resistance (IR) and type 2 diabetes (T2DM), due to their dramatically increasing prevalence. Glucocorticoids (GCs) are potent modulators of skeletal (Sk) muscle insulin sensitivity, as exemplified in patients with GC excess, Cushing’s syndrome, who develop IR and T2DM. Importantly, increased GC generation locally in muscle may contribute to the phenotype in T2DM patients. Although the precise molecular mechanisms driving IR in both T2DM and Cushing’s syndrome are unclear, dysregulated lipid metabolism is a common feature of insulin resistant muscle. This proposal aims to identify how GCs regulate intramyocellular lipid metabolism, and how this impacts on muscle insulin sensitivity. In addition, we will test a novel therapeutic target involved in mediating the metabolic actions of GCs, recently described by Dr Carolyn Cummins, the supervisor of the outgoing phase of this proposal. The complementary expertise in integrative molecular physiology of Dr Cummins, and of the Experienced Researcher, Dr Stuart Morgan, dovetail nicely within an established multi-disciplinary collaborative network of pharmacologists, molecular biologists and analytical chemists at the University of Toronto that have a unifying goal to uncover novel mechanisms regulating IR. Specifically, this proposal employs a systems approach by integrating both in vivo and in vitro pharmacological and genetic manipulation, with lipidomic/proteomic profiling and in-depth molecular characterisations. This novel strategy will significantly advance our understanding of key processes regulating insulin sensitivity in Sk muscle, a process essential for normal glucose homeostasis.

Keywords: insulin resistance,skeletal muscle,type 2 diabetes,cushing s syndrome
Engineered two-dimensional hetero-architectures for nanoelectronics (2D Hetero-architecture)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-24
End date: 2018-03-23
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

Graphene – a single layer of carbon atoms – exhibits a unique combination of superior properties, which makes it a credible starting point for new disruptive technologies in a wide range of fields. However, the absence of an energy gap in its electronic band structure prevents at present its integration in digital logic devices. This research project will tackle the challenge by incorporating nanometer-size boron nitride or boron carbon nitride barriers in graphene domains. These lateral hetero-structures will be used as channel elements in field-effect transistors, whose electron transport properties will be evaluated by a combination of high- and low-temperature electrical measurements. The synthesis of the hetero-structures will be extensively investigated through optical, electronic, probe microscopy and spectroscopy analyses. This approach is designed to take a holistic view of the synthesis process, not only hunting for the highest apparent quality of the grown nano-structures, but also gaining an understanding of the underlying atomistic growth mechanism, so as to enble engineering of these structures.The project will advance European scientific competitiveness in the field of synthesis of 2D hetero-structures, currently a prerogative of a select few US groups, and will provide new platforms which might represent a viable option to obtain graphene-based transistors suitable for digital logic.The multidisciplinary aspect of the project will allow me as experienced researcher to gather knowledge in topics as different as synthesis of nanomaterials, electronic device manufacturing, and low-temperature electrical characterization. It will also allow me to re-integrate the European scientific network, after my postdoc experience in the US, forming a perfect basis of my goal of establishing an independent research group in a European university.

Keywords: two dimensional crystals,chemical vapor deposition synthesis,field effect transistor,hetero structures