Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Digital Intelligent MOdular FACtories (DIMOFAC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Innovation actions
Countries involved: Italy,Austria,Germany,Italy,Germany,Spain,Spain,Spain,Spain,Ireland,Italy,Greece,Switzerland,Switzerland,Belgium,Poland,Sweden,Switzerland,France,France,France,France,France,France,Netherlands,Netherlands,Luxembourg,Denmark
Call: Pilot lines for modular factories (IA 50%) (H2020-NMBP-FOF-2019, 2019)
Start date: 2019-10-01
End date: 2024-03-31
Duration (months): 54.0
Total project cost (EUR): 19133232.49
EU funding (EUR): 14163497.63
Participants: 37
Project status: SIGNED

The digitalization of industry opens the path for mass customization but requires leveraging the existing manufacturing ecosystems and establishing a collaborative manufacturing environment. DIMOFAC project will enable the modularity, adaptability and responsiveness of a production line by the integration of Plug-and-Produce modules in a Closed-Loop Lifecycle Management System, for continuous production adaptation, optimization and improvement, in a fast and flexible manner. Reconfigurability is achieved by implementing a Digital Twin of each module and by deploying Digital Thread linking product and process dataflow, enabling seamless secure communication throughout the product lifecycle in factory and connecting it to the management systems in conformance to RAMI4.0. The DIMOFAC consortium is issued from the leading European open initiatives on smart manufacturing, leveraging know-how from past and running EU projects such as INTEGRADDE, COMMUNION, HIMALAIA, BRAINPORT, iM²AM, MIDIH, MARKET 4.0 and building upon a pre-existing network of open DIHs and competence centers such as SMART FACTORY KL, PICTIC, FFLOR, AFH, MANUHUB@WG. Partners will further extend their services and networks to leverage on the increased flexibility brought by modular production systems. Six industrial pilot lines, with multi-material manufacturing, additive manufacturing and assembly capabilities, will enable to demonstrate DIMOFAC Modular Factory Solution, with reconfiguration time reduction of production lines, up to 75% expected for interactive displays (SCHALTAG), 50% for cosmetic, aeronautic and additive manufacturing (ALBEA, EIRE COMPOSITES and SCULPTEO); 30% for shavers (PHILIPS) and industrial modules (VDL). A key result will be the network of open pilot lines, offering R&T and services supporting process validation and implementation in EU SMEs, Midcaps and large organisations in different sectors, spreading knowledge, awareness and adoption of DIMOFAC Modular Factory Solution.

Keywords: modular production,plug and produce,reconfigurable production lines,mass customization,digital twin,digital thread,closed loop lifecycle management
Carbon Cascades from Land to Ocean in the Anthropocene (C-CASCADES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Germany,Germany,Switzerland,Sweden,Sweden,Belgium,France,Netherlands,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3112980.61
EU funding (EUR): 3112980.61
Participants: 11
Project status: CLOSED

C-CASCADES will produce a new generation of young scientists trained to span the boundaries between disciplines and with the skill-sets required to address one of the grand research challenges of the 21st century: the role of the carbon cycle in regulating Earth’s climate. Training will be embedded within and guided by the overriding science objective of the programme, to make a breakthrough in understanding the transfer of carbon between land and ocean at planetary scale and the consequences for atmospheric CO2 and climate. This will require cutting-edge research and innovation to permit characterization of the transport, transformation and ultimate fate of carbon in rivers, lakes and coastal waters and their representation in Earth System Models. This will allow a better quantification of the fluxes of greenhouse gases (primarily CO2 and CH4) exchanged with the atmosphere and their impacts on the climate system. The closely related training objective is to engage the next generation of Earth system scientists in an integrated, cutting-edge and highly relevant joint research programme. The research undertaken will capture technological innovation in sensor development; advance mechanistic understanding of the carbon transformations that occur during lateral transfer between land and ocean; embed this understanding in enhanced catchment, regional and global-scale models; and, assess quantitatively carbon transfer fluxes and carbon transformations along the land to ocean aquatic continuum at the global scale, from terrestrial ecosystems to the open ocean via rivers, lakes and coastal waters. The suite of C-CASCADES models will be progressively improved during the course of the project and evaluated against observations. These models will be applied to disentangle human impacts (e.g. land-use, river management, wastewater production, CO2, climate) on the land-to-ocean carbon cycle, for the historical period and future IPCC climate scenarios.

Keywords: global carbon cycle,earth system models,carbon and greenhouse gas measurements,land ocean interactions
Training network providing cutting-EDGE knowlEDGE on Herpes Virology and Immunology (EDGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Italy,Germany,Germany,Netherlands,Netherlands,United Kingdom,Denmark
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2016-05-01
End date: 2020-10-31
Duration (months): 54.0
Total project cost (EUR): 3961943.28
EU funding (EUR): 3961943.2800000003
Participants: 9
Project status: CLOSED

Herpesviruses are widely spread, and cause life-long infections. Most individuals carry multiple herpesviruses, which can cause severe diseases, especially in children, immunocompromised individuals, and elderly. There are currently no safe vaccines against herpesvirus infections and current treatments are not satisfactory. With new insights into the molecular basis for diseases caused by immunodeficiency, and with the increasing numbers of elderly in Europe, there is now an unmet demand for improved treatments of herpesvirus infections. Combined with the progress in basic herpesvirus research, this calls for education of a new generation of scientists with strong research skills, advanced insights into disease mechanisms, and understanding of how industry brings innovative research into the market. In this application we propose an interactive education program for early stage researchers (ESR) in leading European laboratories, hospitals, and biotech companies. The focus will be on the virology and immunology of herpesvirus infections in the context of basic research as well as application of research-acquired knowledge. Our program will prepare the ESRs to manage goal-oriented interactions between academia, the clinics, and the biotech industry. The ESRs will acquire broad theoretical and methodological expertises involving several sectors to obtain the skills required for overcoming the cultural gaps From Bench to Bedside and From Discovery to Innovation. This can only be achieved through a network-based approach. We propose to develop a platform to educate the next generation of scientists to solve the outstanding problems in prevention and treatment of herpesvirus infections. The ESRs will be ideally trained to translate cutting-edge discoveries to novel products and to innovative treatment serving the European people, and hence to improve handling of present and emerging health challenges, as well as to foster the European biopharmaceutical industry sector.

Keywords: herpesviruses,innate immunology,academia hospital industry interactions
Memory research: Ground-breaking, Applied, and Technological Exchanges (M-GATE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Israel,Norway,Belgium,Belgium,France,France,United States,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2017-10-01
End date: 2022-03-31
Duration (months): 54.0
Total project cost (EUR): 3961159.56
EU funding (EUR): 3961159.5599999996
Participants: 11
Project status: CLOSED

In M-GATE, ESRs will combine state-of-the art experimental neurophysiology, innovative technologies, and advanced theoretical approaches to unveil memory mechanisms, from single neurons to brain networks, to cognition and behaviour, addressing the healthy and diseased brain. Through research and training from top-class scientists and close interaction with industrial partners, ESRs will develop unique multi-disciplinary skills combining physiology, molecular biology, computation, micro-engineering, and entrepreneurship The exploration of the hippocampal formation and its role in memory is one of the great success stories of neuroscience. For no other structure have neuroscientists achieved such an in-depth knowledge of structure and mechanisms, making this field one of the most promising for breakthroughs in understanding human cognition. Our program will include world-leading, Europe- and US-based scientists in academic institutions as well as pharmaceutical, neurotechnological and machine learning companies, with the task of developing new technologies to understand memory and advance our chances to cure brain pathologies. Early-stage researchers will participate in scientific programs spanning hippocampus research broadly, from local circuital interactions at one brain site, to global networks including multiple brain structures. Dedicated projects will look at brain pathologies as epilepsy and Alzheimer’s from the circuits point of view. A neurotechnology work package spanning multiple projects will include novel methodological developments, bringing together academic and private sector technologists. With the help of targeted secondments and a tailored training program, we provide a unique opportunity for talented researchers to prepare for a career in either academic research or the private sector.

Keywords: hippocampus,spatial cognition,neurotechnology,translational neuroscience,optogenetics
Scaling-up the involvement of women in supporting and accelerating market uptake of renewable energy sources for heating and cooling (W4RES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Coordination and support actions
Countries involved: Germany,Germany,Italy,Italy,Norway,Belgium,Bulgaria,Slovakia,Greece,Denmark
Call: Market Uptake support (H2020-LC-SC3-2020-RES-IA-CSA, 2020)
Start date: 2020-11-01
End date: 2023-10-31
Duration (months): 36.0
Total project cost (EUR): 2999658.75
EU funding (EUR): 2999658.75
Participants: 12
Project status: SIGNED

Women hold great potential as agents of change, driving the clean energy transition and getting us closer to meeting the EU’s climate and energy targets for 2030. W4RES taps into this potential to support the uptake of renewable energy in heating and cooling (RHC), a market that urgently needs to shift more to RES. We start with a deep dive into framework conditions and regional specificities of 8 diverse yet representative markets in Europe, assessing enablers and barriers to RHC uptake. Building on gender-disaggregated insights from market actors and stakeholders as well as successful cases of women leading RHC projects, we develop a suite of flexible and cost-effective support measures with high reapplication potential. We then deploy our measures on the field offering technical and business support to cut down project development timings and efforts as well as to sidestep legal, institutional and financial challenges, setting in motion feasible and sustainable business models fit to market. In parallel, we empower decision-makers to leverage a gender perspective into their projects and policies to improve acceptance, while raising awareness to foster demand for RHC. Along the way, a gender-responsive monitoring and evaluation framework will gauge the performance and impact of our measures, providing us with the intel required to turn them from solutions fit for a set of local challenges to integrated solutions that can address diverse policy and market needs across Europe. We use this intel as a catalyst to foster co-creation, mutual learning and international cooperation for frameworks more conducive to RHC uptake at local, regional national and EU level, based on cost-effective support schemes and lower financing costs for RHC facilities. In the process, we coordinate our actions with relevant initiatives and offer tools to facilitate the reapplication of our results, ensuring their long-term sustainability as viable solutions to supporting RHC uptake.

Keywords: renewable energy sources,market uptake support,heating and cooling,renewable heating and cooling,renewable energy,gender,business support,capacity building,mutual learning,quadruple helix
Paris Agreement Overshooting – Reversibility, Climate Impacts and Adaptation Needs (PROVIDE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Australia,Germany,Switzerland,Switzerland,Belgium,Norway,Norway,Belgium,France,United Kingdom,United Kingdom,Canada,Pakistan,Portugal
Call: Advancing climate services (H2020-LC-CLA-2020-2, 2020)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 6089538.75
EU funding (EUR): 5994538.75
Participants: 20
Project status: SIGNED

Overshooting the Paris Agreement temperature thresholds is a distinct possibility. The impacts of such overshoot scenarios would materialise globally, but be particularly consequential for vulnerable regions and systems for which thresholds of abrupt and possibly irreversible shifts or adaptation limits may be exceeded. A full consideration of impacts and adaptation needs under overshoot scenarios thus requires a risk threshold perspective integrating emission pathways, earth system feedbacks, regional to local impacts, and context-specific vulnerabilities. To address that challenge, PROVIDE will deliver highly innovative, integrative climate services that incorporate comprehensive information on impacts under overshoot pathways from the global to the regional and urban level, directly feeding into adaptation action. The project specifically aims to: 1) Produce global multi-scenario, multi-sectoral climate information which integrates and quantifies impacts across scales by means of novel climate and impact emulators; 2) Assess climate system uncertainties and feedbacks, and the (ir)reversibility of climate impacts to provide comprehensive risk assessments of overshooting; 3) Co-develop a generalisable overshoot proofing methodology for adaptation strategies to enhance adaptation action in response to overshoot risks; 4) Identify and prioritise overshoot adaptation needs in four highly complementary case study regions; 5) Integrate all project outcomes into a PROVIDE Climate Service Dashboard. The Dashboard will be designed to complement established climate service platforms and will be widely disseminated to foster uptake and sustainable use across all stakeholder groups addressed. The PROVIDE consortium is constituted of leading climate scientists as well as climate services purveyors, urban planners and adaptation experts embedded in selected case study regions facilitating a continuous co-development process with a wide array of stakeholders.

Keywords: climate services,earth system feedbacks,high warming risks,irreversible impacts,urban planning,paris agreement,overshoot scenarios
The role of immune cells in Alzheimer's disease (IMMUNOALZHEIMER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Italy
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Alzheimer’s disease is the most common form of dementia affecting more than 35 million people worldwide and its prevalence is projected to nearly double every 20 years with tremendous social and economical impact on the society. There is no cure for Alzheimer's disease and current drugs only temporarily improve disease symptoms. Alzheimer's disease is characterized by a progressive deterioration of cognitive functions, and the neuropathological features include amyloid beta deposition, aggregates of hyperphosphorylated tau protein, and the loss of neurons in the central nervous system (CNS). Research efforts in the past decades have been focused on neurons and other CNS resident cells, but this "neurocentric" view has not resulted in disease-modifying therapies. Growing evidence suggests that inflammation mechanisms are involved in Alzheimer's disease and our team has recently shown an unexpected role for neutrophils in Alzheimer's disease, supporting the innovative idea that circulating leukocytes contribute to disease pathogenesis. The main goal of this project is to study the role of immune cells in animal models of Alzheimer's disease focusing on neutrophils and T cells. We will first study leukocyte-endothelial interactions in CNS microcirculation in intravital microscopy experiments. Leukocyte trafficking will be then studied inside the brain parenchyma by using two-photon microscopy, which will allow us to characterize leukocyte dynamic behaviour and the crosstalk between migrating leukocytes and CNS cells. The effect of therapeutic blockade of leukocyte-dependent inflammation mechanisms will be determined in animal models of Alzheimer's disease. Finally, the presence of immune cells will be studied on brain samples from Alzheimer's disease patients. Overall, IMMUNOALZHEIMER will generate fundamental knowledge to the understanding of the role of immune cells in neurodegeneration and will unveil novel therapeutic strategies to address Alzheimer’s disease.

Keywords: leukocyte trafficking,vascular inflammation,neutrophils,t cells,intravital microscopy,neuroinflammation,neuroimmunology,alzheimer s disease
Multiplying In Africa European Global Navigation Initiatives Fostering Interlaced Cooperation (MAGNIFIC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Innovation actions
Countries involved: Spain,Switzerland,Belgium,France,France,Togo,Senegal,Luxembourg
Call: Releasing the potential of EGNSS applications through international cooperation (H2020-Galileo-2014-1, 2014)
Start date: 2015-02-01
End date: 2017-07-31
Duration (months): 30.0
Total project cost (EUR): 2342591.25
EU funding (EUR): 1416162.5
Participants: 11
Project status: CLOSED

MAGNIFIC project aims to enable the development of EGNSS applications through international cooperation. MAGNIFIC proposes to demonstrate to African Stakeholders the benefits of EGNOS and Galileo in 6 market sectors: airport surface vehicle, flight trials, Oil exploitation, Natural resources, highly secured multi-modal transport and use of secured Maritime transport. These applications have been selected based on the 6 priority applications identified in the GSA Action plan on GNSS applications The selection of Africa was done taking into account that the provision of SBAS over AFI has been considered by EU since the early phase of development of EGNOS. Particularly, countries from West Africa have been selected being those countries the ones with the highest growth foreseen for the next 5 years. Certainly, one of the key aspects of the proposed solution is the possibility of the consortium of simulating EGNOS signal thanks to Thales Alenia Space SPEED platform. Other key aspects from our solution to be highlighted are: • Full range of partners allowing networking among European SMEs, European Industry European Research Centres, African academia, African Air Navigation Stakeholders, African SMEs and African petrol companies • High innovation character, attracting the most important regional companies from Africa, who have committed officially to an active and in-kind participation in the project, multiplying the impact of MAGNIFIC. • Galileo SAR demonstrations and Oil exploitation demonstrations showing the added value of GALILEO early services. MAGNIFIC project will allow fostering application development through international cooperation, awareness of EGNOS and GALILEO applications outside Europe and ensuring networking among different kind of actors from Europe and Africa.

Keywords: africa,egnss,aviation,maritime,multimodal,road,scintillation,speed platform,field trials,galileo sar