Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Sensing and predictive treatment of frailty and associated co-morbidities using advanced personalized patient models and advanced interventions (FrailSafe)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Cyprus,Belgium,Greece,Greece,Greece,France
Call: Advancing active and healthy ageing with ICT: Early risk detection and intervention (H2020-PHC-2015-single-stage, 2015)
Start date: 2016-01-01
End date: 2019-04-30
Duration (months): 40.0
Total project cost (EUR): 3820896.25
EU funding (EUR): 3820896.25
Participants: 9
Project status: CLOSED

Ageing population is steeply increasing worldwide. A consequence of age related decline is the clinical condition of frailty. Frailty is a biological syndrome of decreased reserve and resistance to stressors, resulting from cumulative declines across multiple physiologic systems and causing vulnerability to adverse outcomes. Susceptibility to stressors is influenced by biological, behavioral, environmental, and social risk factors, with the main consequence being an increased risk for multiple adverse health outcomes, including disability, morbidity, falls, hospitalization, institutionalization, and death. However, frailty is a dynamic and not an irreversible process; it seems preventable, may be delayed, or reversed. Our understanding of frailty has markedly improved over the last five years, yet there are many issues yet to be resolved. FrailSafe aims to better understand frailty and its relation to co-morbidities; to identify quantitative and qualitative measures of frailty through advanced data mining approaches on multiparametric data and use them to predict short and long-term outcome and risk of frailty; to develop real life sensing (physical, cognitive, psychological, social) and intervention (guidelines, real-time feedback, AR serious games) platform offering physiological reserve and external challenges; to provide a digital patient model of frailty sensitive to several dynamic parameters, including physiological, behavioural and contextual; this model being the key for developing and testing pharmaceutical and non-pharmaceutical interventions; to create “prevent-frailty” evidence-based recommendations for the elderly; to strengthen the motor, cognitive, and other “anti-frailty” activities through the delivery of personalised treatment programmes, monitoring alerts, guidance and education; and to achieve all with a safe, unobtrusive and acceptable system for the ageing population while reducing the cost of health care systems.

Keywords: frailty metrics,standardized measurements,diagnosis,unobtrusive continuous assessment,risk detection and prediction,decision support,augmented reality games
From Simplicity to Complexity: Crafting Molecular Architectures via Cascade Polyene Cyclizations (CRAFTMOL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-02-01
End date: 2027-01-31
Duration (months): 60.0
Total project cost (EUR): 1998767.0
EU funding (EUR): 1998767.0
Participants: 1
Project status: SIGNED

Polyene cyclizations belong to the most powerful and fascinating chemical transformations to rapidly assemble molecular architectures. However, the very limited substitution pattern of known substrates and nature’s inability to accommodate heteroatoms or substituents other than methyl restrict molecular diversity, complexity and functionality. CRAFTMOL addresses these limitations by investigating a set of novel heteroatom-substituted and tri/tetrasubstituted polyenes. The participation of these structural units in the cyclization will unlock previously inaccessible reaction pathways and enable efficient, selective and practicable routes to anticancer, anti-inflammatory and antiviral molecules. We will first investigate substrates containing trisubstituted double bonds and explore their behavior in cyclizations involving a transannular/cross-termination step. Realization of this concept will provide a highly modular synthetic platform for the rapid construction of more than 15 bioactive natural products. For the second part, we will explore tetrasubstituted double bonds to realize first-time synthesis of a structurally diverse family of natural products with unique biological activities. We will accomplish these goals by taking advantage of our expertise in total synthesis of complex natural products and modern chemical methodology. The experiments will be guided by computational methods and supported by our high-pressure platform. CRAFTMOL is ground-breaking as it 1) unveils innovative reaction pathways, 2) provides efficient synthetic access to structurally diverse molecular architectures, 3) enables deep-seated structural modifications of natural molecules that are currently inaccessible via fermentation or semi-synthesis. CRAFTMOL will lead to a better understanding of polyene cyclizations, will inspire scientists to develop novel methods for the construction of highly valuable molecules and will therefore advance the entire field of chemical synthesis.

Keywords: natural products,total synthesis,terpenes,polyene cyclizations
Institutional Family Demography (IFAMID)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Italy
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2022-03-31
Duration (months): 66.0
Total project cost (EUR): 1850820.0
EU funding (EUR): 1850820.0
Participants: 1
Project status: CLOSED

IFAMID presents a new framework for the analysis of family demography. Drawing on recent theoretical developments, and exploiting cognitive and methodological insights from a wide range of disciplines, most importantly from sociology and political science, it is argued that trends in family formation (and its dynamics) not only derive from broad global forces, but also from institutional "quality" and cultural traits, and, critically important, from the interaction between the two. Whereas the framework is general, the empirical side of the project focuses on explaining 1) fertility trends and differentials in OECD countries, 2) the transition to adulthood, and 3) the global perspective of fertility change. An important aspect of this approach is that policies contained within existing welfare constellations, often taken as explanatory factors for family outcomes, are necessarily endogenous, and its evolution depends on the underlying quality of relevant institutions and cultural traits, which may react very differently with respect to the onset of global trends, and therefore give different patterns of family formation. With this project, a series of hypotheses will be developed and empirically tested. The World Values Surveys will serve as an important data source, but the unit of analysis will be in large part at the regional level since it is impossible to account fully for the complex interaction of culture and institutions from a cross-country perspective only. This implies collecting a chronology of regional variables on cultural traits, institutions and demographic outcomes. Working closely with Gosta Esping-Andesen and with a team of historical demographers led by Guido Alfani (Bocconi), and drawing heavily on the statistical modeling skills of the PI, the aim is to devise a set of state-of-the-art techniques including instrumental variables, spatial econometrics and epidemiological approaches that deal with the endogeneity of culture and institutions.

Keywords: transition to adulthood,family demography,social demography,instrumental variables,spatial econometrics,regional studies,global approach,path dependency,social institutions,epidemiology
New cross sEctorial value chains creation across EuroPe faciliTated by clUsters for SMEs's INnovation in BluE Growth (NEPTUNE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Innovation actions
Countries involved: Spain,Italy,Spain,Poland,Sweden,Romania,Greece,France,France,France,France,France
Call: Cluster faciltated projects for new value chains (H2020-INNOSUP-2015-1, 2015)
Start date: 2016-07-01
End date: 2018-12-31
Duration (months): 30.0
Total project cost (EUR): 4199821.61
EU funding (EUR): 4158735.25
Participants: 15
Project status: CLOSED

The EU faces huge challenges in food security, sustainable agriculture, marine and maritime and inland water management. Blue Growth solutions can play an important role in meeting these challenges and unlock the potential of oceans and inland water for the benefit of European competitiveness. Blue Growth is identified as a key emerging industry to be supported via inter cluster collaboration as well as a key driver for the EU economy. NEPTUNE aims at developing new cross-sectoral and cross-border industrial value-chains, including notably SMEs, to foster the development of Blue Growth industries in Europe and beyond. This will be based on the construction or reconfiguration of value chains driven by the integration of new technologies and know-how between Water, Aerospace, ICT and Agriculture industries. NETPUNE addresses in particular three key aspects of Blue Growth that have a great potential to benefit from such collaboration and SME innovation support: (i) Water management in urban and rural environments; (ii) Fluvial and maritime transport and port logisitics; (iii) Environment and renewable marine energy. From a methodological perspective, NEPTUNE focuses on two main concepts: the innovative Open Space Platform that refers to the collaborative space and innovation animation techniques via a project emergence methodology that helps SMEs and other stakeholders to identify market trends and opportunities and support the incubation of Blue Growth projects and innovation ideas. NEPTUNE expects to support at least 100 SMEs for the development of 40 new innovative solutions. NEPTUNE brings together 10 of Europe’s leading clusters from 7 countries and 2 additional innovation, creativity and inter-cluster expert organisations to implement this ambitious project.

Keywords: blue growth,cross sectoral,water,aerospace,agriculture,internationalisation,creativity,innovation methodology
Earth Observation Training in Science and Technology at the Space Research Centre of the Polish Academy of Sciences (EOTiST)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Spain,Italy,Greece,Poland
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2020-10-01
End date: 2024-03-31
Duration (months): 42.0
Total project cost (EUR): 896875.0
EU funding (EUR): 896875.0
Participants: 4
Project status: SIGNED

EOTiST aims to enhance the S&T capacity of the Space Research Centre of the Polish Academy of Sciences (CBK PAN) and to achieve excellence in research of EO products’ assimilation in the ecosystem assessment and monitoring by starting close collaboration with 3 European centres of excellence: CERTH, CREAF, CNR. Specific goals are to be pursued: - Enhance S&T capacity of the coordinating institution. Training activities targeted to the exact needs of the CBK PAN constitute the key part of EOTiST, after a dedicated SWOT analysis. Existing non-exploited potential will be enhanced and further training of the personnel and affiliated scientists performed. - Upgrade research profile of the CBK PAN and the profile of its staff by mobilizing and training of personnel. Key training actions include workshops, staff visits, and on-line courses and target PhD students, early stage researchers, postdoctoral students, researchers and administrative staff. - Increase research excellence and stimulate innovation of the coordinating institution. EOTiST will build on CNR, CREAF and CERTH excellence and their networks to advance CBK PAN research and innovation performance through knowledge transfer and exchange of best practices. - Achieve sustainable progress and future development for the today’s seed group in CBK PAN. The partners will develop a strategic partnership based on reinforced dialogue and consultation. EOTiST will explore collaboration chances with local stakeholders and perform a market and product feasibility analysis to introduce new products/ technologies within Poland. - Promote the involvement of early stage researchers in the CBK PAN. Early stage researchers will be acquainted with specific knowledge and technical skills to organise scientific work and present research results. - Develop joint research initiatives and projects. Partners will mobilize existing networks and resources to formulate research initiatives and projects. - Enhance CBK PAN management skills

Keywords: earth observation,ecosystem services,capacity building
PRIFOG - A technology-powered producer responsibility initiative for fat, oil and grease compliance for food service outlets (PRIFOG)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Ireland
Call: Innovative mobile e-government applications by SMEs (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Evolution Environmental Services Ltd (EES) is an environmental consultancy business that provides outsourced fat, oil & grease (FOG) source control programmes to city authorities in Ireland. FOG is a major contributing factor to sewer blockages in urban areas that poses challenges to sewer asset managers, and adversely affects citizens in cities worldwide. To combat this problem, many cities impose regulations on food service outlets (FSOs) in the form of a FOG source control program. However satisfying these regulations places a significant financial and operational burden on food service outlets. The goal of this Action is to develop a feasibility study for PRIFOG, a technology-based producer responsibility initiative for FOG compliance. PRIFOG’s cloud based software solution provides a platform that connects the city authority with the FSO and allows both stakeholders to manage, verify and validate compliance online. PRIFOG fosters a positive relationship between FSO’s and the city authority by providing independent advice, guidance, training and promoting best practice for FOG compliance. The feasibility study of PRIFOG will be completed by delivering four key objectives; 1) conduct a detailed market analysis, 2) proof of concept pilot study within the Irish market, 3) develop a detailed product roadmap based on customer needs, and, 4) develop an elaborated investor-ready business plan to scale the PRIFOG solution to international markets. PRIFOG uses emerging technology to address two problems that are replicated in almost every city worldwide. Firstly, PRIFOG reduces the problems caused by FOG in drainage networks. Secondly, PRIFOG provides a solution that reduces the burden of regulation on FSOs.

Keywords: better regulation
Perception of Plant Volatiles (PERVOL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2022-02-28
Duration (months): 60.0
Total project cost (EUR): 1989938.0
EU funding (EUR): 1989938.0
Participants: 1
Project status: CLOSED

The capacity to produce and perceive organic chemicals is essential for most cellular organisms. Plant leaves that are attacked by insect herbivores for instance start releasing distinct blends of herbivore-induced plant volatiles, which in turn can be perceived by non-attacked tissues. These tissues then respond more rapidly and more strongly to herbivore attack. One major question that constrains the current understanding of plant volatile communication is how plants perceive herbivore induced volatiles. Can plants smell danger by detecting certain volatiles with specific receptors? Or are other mechanisms at play? Answering these questions would push the boundaries of plant signaling research, as it would allow for the creation of perception impaired mutants to perform detailed analyses of the biological functions and potential agricultural benefits of plant volatile perception. My recent work identified indole as a key herbivore induced volatile priming signal in maize. As indole is produced by many different plant species and has been well studied as a bacterial volatile, it is an ideal candidate to study the mechanisms and biological functions of plant volatile perception. The key objectives of PERVOL are 1) to develop a new high-throughput plant volatile sampling system for genetic screens of indole perception, 2) to use the system to identify molecular mechanisms of indole perception and 3) to create indole perception mutants to uncover novel biological functions of volatile priming. If successful, PERVOL will set technological standards by providing the community with an innovative and powerful volatile sampling system. Furthermore, it will push the field of plant volatile research by elucidating mechanisms of herbivore induced volatile perception, generating new genetic resources for functional investigations of plant volatile signaling and testing new potential biological functions of the perception of herbivore induced volatiles.
Emergent Marine Toxins in the North Atlantic and Mediterranean: New Approaches to Assess their Occurrence and Future Scenarios in the Framework of Global Environmental Changes. (EMERTOX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Italy,Spain,Tunisia,France,Dominican Republic,Czechia,United Kingdom,Cabo Verde,Morocco,Portugal,United Kingdom,United Kingdom,United Kingdom
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-03-01
End date: 2023-10-31
Duration (months): 68.0
Total project cost (EUR): 702000.0
EU funding (EUR): 702000.0
Participants: 17
Project status: SIGNED

EMERTOX aims at mapping the actual situation in emergent marine toxins and the producing organisms, developing new approaches to assess their occurrence and predicting the possible future scenarios in the framework of global warming. The partnership, formed by a multidisciplinary team, will produce a joint research and innovation project that will exploit the complementary expertise of the participants and will create synergies among them. The main objectives are: 1- to assess the current situation on potentially harmful algae and bacteria and the relevant emerging toxins in 8 countries belonging to different but geographically connected areas (Mediterranean Sea and North Atlantic); 2- to develop innovative approaches to sample, and analyze the producing organisms and their toxins by chemical and biological methods including immunoassays and sensors; 3- to estimate different future scenarios based on molecular data (routes of dispersion) and modelling.

Keywords: emergent,marine toxins,mapping,sampling strategies,biological methods,chemical methods,sensors,in situ systems,models,environmental change,toxicology,multidisciplinary approach,risk,assessment
Wearable Applications enabled by electronic Systems on Paper (WASP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Spain,Italy,Italy,Switzerland,United Kingdom
Call: Flexible and Wearable Electronics (H2020-ICT-2018-2, 2018)
Start date: 2019-01-01
End date: 2022-06-30
Duration (months): 42.0
Total project cost (EUR): 3362122.5
EU funding (EUR): 3362122.5
Participants: 8
Project status: CLOSED

The WASP project aims at bringing the much-needed step change in flexible and wearable electronics by developing a new industrially driven enabling printing technology for the definition of electronic devices and circuits on paper, a flexible and foldable substrate, which is low cost, disposable, biodegradable, easily obtainable in nature and compatible with high speed roll-to-roll processes. The proposed technology is based on an environmentally friendly process and addresses the needs for future circular economy, as well as that for cheap, flexible and lightweight, multi-functional electronics. At the end of the project, a demonstrator will be released, able to sense biometric parameters (i.e., humidity, pH, glucose levels) and to communicate to an external reader, developed on purpose within the WASP activity.

Keywords: printable and flexible electronics,two dimensional materials,rfid,biosensors,solar cells,health