Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Design and synthesis of novel inhibitors of the anti-infective target IspE (KpIspE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

Due to the current antimicrobial resistance crisis, addressing underexplored targets to afford anti-infective compounds with novel modes of action is urgently needed. Antimicrobial resistance not only poses a threat to public health, but is a substantial cost burden on the healthcare system. This proposal focuses on the design and synthesis of novel inhibitors of the target 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE). IspE catalyzes the fourth step in the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway which is essential for medically relevant pathogens (e.g., Enterobacter coli, Klebsiella pneumoniae, Mycobacterium tuberculosis and Pseudomonas aeruginosa) but entirely absent in humans, making this enzyme a promising drug target. We will initially explore drug fragments through the screening of carefully constructed fragment libraries, followed by hit-to-lead optimization for promising compounds. Target confirmation will be performed using a biologically active small-molecule photo-crosslinking probe and a crystal structure of IspE obtained in complex with a promising inhibitor. The investigation of potential for therapeutic intervention via inhibition of IspE will result in several potent inhibitors, enhancing the knowledge of this underexplored enzyme target and opening up access for further exploration of potent inhibitors. This research will greatly contribute to the discovery of novel anti-infective agents, leading to decreased morbidity and mortality in patients, economical benefits for the health care system in the European Union as well as globally.

Keywords: anti infective,ispe,hit to lead optimization,fragment growing,methyl erythritol phosphate pathway
Dypha: adding the dimension of time to cell culture (Dypha)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Challenges
Action type: EIC actions
Countries involved: Netherlands,Germany,Italy
Call: EIC Transition Challenge: Full scale Micro-Nano-Bio devices for medical and medical research applications (HORIZON-EIC-2023-TRANSITION-01, 2023)
Start date: 2024-04-01
End date: 2027-03-31
Duration (months): 36.0
Total project cost (EUR): 2499625.0
EU funding (EUR): 2499625.0
Participants: 6
Project status: SIGNED

The current preclinical drug development pipeline is highly inefficient with 9 out of 10 drugs failing when first tested in humans. Of those failures, between 69% and 81% is due to a lack of efficacy (52-57%) or safety (17-24%), indicating that the predictivity of currently used cell culture and animal models is not high enough. While promising human cell culture models have arisen in the last decades (e.g. pluripotent stem cell models, spheroids, organoids), the environment of these models is too simplistic to reach their full potential and to translate certain responses to humans. One of the important aspects missing in current cell culture is kinetics: many processes in the human body have response times with resolutions of seconds, minutes or hours. In standard cell culture however, such temporal resolution is absent because cell culture medium remains unchanged for typically 1-3 days. So for kinetics, scientists turn to animal models with relatively low translational success and high costs. As an alternative, complex microfluidic setups have been used to enable perfusion in vitro and demonstrated a significant amount of evidence that kinetics can improve the relevance of cell culture models. Despite the evidence, typical cell culture biologists are not taking kinetics into account because the tools to control kinetics in cell culture are too complex. We solve this problem by starting from what cell culture biologists currently use: a standard well plate. We developed a µFluidic Adaptor that can be clamped on any 96 well plate and completely replaces the fluid in the well homogenously without disturbing the cell culture. Our goal is to develop a plug-and-play peripheral system that integrates automated fluidics and microscopic readout in a fully controlled environment: the δypha System. The system uses µFluidic Adaptors that can be designed for different applications or well plate formats.

Keywords: microphysiological systems,microfluidic system,pharmocokinetics,high throughput and automated drug testing,personalized medicine,kinetic organoid culture,3d organoid culture optimization
The most important think tank you’ve never heard of: Resources for the Future and the history of economic thought in environmental practice (REFUTURE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-06-01
End date: 2027-02-28
Duration (months): 33.0
Total project cost (EUR): 216699.6
EU funding (EUR): 216699.6
Participants: 4
Project status: SIGNED

The proposed project will undertake an historical analysis of the development, role and impact of the Washington DC based think tank Resources For the Future (RFF) - from its founding in 1952 to the late 1990s. REFUTURE investigates RFF’s role in constructing an economic vision of the environment around the concepts of scarcity, value, and externalities; and the subsequent application of that vision through US and international policies focused on managing the environment in relation to economic efficiency. By focusing on this history of economic thought in environmental practice, REFUTURE raises larger political economic questions regarding the contribution of RFF to i) the global ‘great acceleration’ of the Anthropocene in terms of material throughput and pollution concomitant with an emphasis on economic growth from the middle of the twentieth century; ii) what I call here the ‘great deceleration’ of effective environmental and climate policy from the early 1980s on – due to the overwhelming political focus on maintaining economic growth by governing nature and managing environmental impacts through the price mechanism. Drawing from the methodologies of intellectual history, economic sociology and historical political economy, I will undertake research at a number of key libraries and archives in the US and will significantly benefit from outbound placements and training at the Center for the History of Political Economy (HOPE) at Duke University and the Institute at Brown for Environment and Society (IBES) at Brown University. Overall research direction will greatly benefit from a placement at the Institute of Environmental Science and Technology (ICTA) at Universitat Autònoma de Barcelona – a key European centre for research and critical analysis into the relationship between economic growth and environmental sustainability. As an affiliated researcher here I will bring key insights from historical analysis of the applied economics of the environment.

Keywords: historical political economy political economy of the environment history of economic thought anthropocene neoliberal governance history of economic growth history of environmental policy
Interdisciplinary Perspectives on the Politics of Adolescence and Democracy (IP-PAD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,Germany,Greece,Poland,Austria,United Kingdom,Belgium
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 2567325.6
EU funding (EUR): 2567325.6
Participants: 11
Project status: SIGNED

IP-PAD (Interdisciplinary Perspectives on the Politics of Adolescence & Democracy) aims to address a timely, pressing societal issue, namely the understanding of how young adolescent citizens process political information and how this affects their engagement with politics. Youth engagement with politics has always been crucial for the future of democracy as the adolescents of today become the voting citizens of tomorrow. Their political engagement seems even more important today as we have witnessed a decline in youth satisfaction with democracy, while at the same time the social and political challenges of climate change, misinformation, declining voter turnout, polarization and radicalization raise concerns about the future of liberal democracies in Europe. To address these aims, IP-PAD will integrate, for the first time, in a systematic, rigorous and mutually beneficial way two main areas of research: first, the extensive literature on youth political engagement from the perspective of political and social sciences; and second, the insights on the wide-ranging changes that occur in the adolescent brain, obtained from the field of developmental psychology and neuroscience. While prolific in their own respect, these two perspectives have till now been kept separate. IP-PAD argues that a rigorous understanding of how adolescents process political information requires the integration of these two strands. IP-PAD will fill this gap by studying how the developing adolescent brain in the different sociopolitical contexts of five European countries underpins the emergence of the social, and eventually, political self. By integrating these two perspectives and in collaboration with three major European non-academic partners (European Youth Parliament, Gallup International, Counterpoint Global) IP-PAD will provide an in-depth interdisciplinary training to a young generation of social scientists in conducting open, rigorous, innovative and impactful research.

Keywords: adolescence political behavior polarization emotions democracy cognition ideology political attitudes
Cooperation Of Space NCPs as a Means to Optimise Services for Horizon Europe (plus) (COSMOS4HEplus)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Coordination and support actions
Countries involved: Greece,Germany,Italy,Poland,Serbia,Slovakia,Estonia,United Kingdom,Bulgaria,Lithuania,Portugal,Czechia,Norway,Türkiye,Switzerland
Call: Support for transnational activities of National Contact Points in the thematic areas of Digital, Industry and Space (CSA) (HORIZON-CL4-2024-HUMAN-02, 2024)
Start date: 2025-09-01
End date: 2028-08-31
Duration (months): 36.0
Total project cost (EUR): 999543.75
EU funding (EUR): 999543.75
Participants: 15
Project status: SIGNED

COSMOS4HEplus proposal is the successor of COSMOS4HE and previous projects of Space NCP network. The consortium consists of NCP organisations from 15 countries balancing geographical coverage as well as diversity in level of expertise. The overall aim of COSMOS4HEplus is to support the professionalisation of the services rendered by the National Contact Points in Cluster 4 thematic area of Space in Horizon Europe and provide additional services targeting Space clients and applicants at EU level and beyond. The activities are structured according to the propoCOSMOS4HEplus proposal is the successor of COSMOS4HE and previous projects of Space NCP network. The consortium consists of NCP organisations from 15 countries balancing geographical coverage as well as diversity in level of expertise. The overall aim of COSMOS4HEplus is to support the professionalisation of the services rendered by the National Contact Points in Cluster 4 thematic area of Space in Horizon Europe and provide additional services targeting Space clients and applicants at EU level and beyond. The activities are structured according to the proposal’s specific objectives: 1) to increase the quality and support harmonisation of Space NCPs services, 2) to lower the entry barriers for newcomer applicants, to attract new types of players and applicants from widening countries, as well as to raise the quality of submitted proposals, 3) to increase the visibility of the thematic area of Space to new types of players by organizing matchmaking activities and ensuring bilateral communication about the crosscutting issues throughout Horizon Europe for the benefit of the European R&I community. The consortium will closely cooperate with the two other Cluster 4 NCP networks in thematic areas Digital and Industry developing synergies. Collaboration will be also sought with other NCP networks, EEN and space stakeholders aiming at maximising outreach and impact. Special focus will be put on broadening participation.

Keywords: space,digital,industry,national contact points,capacity building,networking services,human centric approach
InnovAtive DeMonstrator for hyBrid-Electric Regional Application (AMBER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Aviation
Action type: Innovation actions
Partnership: CLEAN-AVIATION (JU-JTI)
Countries involved: Italy,Germany,Czechia,Poland,United Kingdom,Türkiye
Call: Multi-MW Hybrid-Electric Propulsion System for Regional Aircraft (HORIZON-JU-Clean-Aviation-2022-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 38922494.44
EU funding (EUR): 30814783.86
Participants: 22
Project status: SIGNED

Climate change poses an unprecedented challenge on today’s society. Numerous studies highlight the urgent need to decarbonize global industry and to drastically reduce pollutant emissions across all sectors, including aviation. Although, the global environmental impact of aviation is mostly driven by small-medium range market aircraft due to the large volume of operations, the development of disruptive technologies for the power demands such applications require cannot be put in place until progressive maturation of novel enabling technologies has been achieved at lower scale or sizes. The transformation of regional aviation, i.e., aircraft serving distances of 500 to 1000 km at a capacity of up to 100 seats, will thus lead the way towards sustainability and will be of particular importance. Both battery and liquid hydrogen powered fuel cell technology will not be sufficiently matured to allow the realization of a fully electric regional aircraft within the next decade. Instead, an intermediate step will be required to significantly reduce GHG emissions already by 2035. The development of a hybrid-electric propulsion system for regional aircraft with at least 50% hybridization represents this very challenging, yet achievable intermediate step and can allow for a mission fuel burn reduction by at least 30% compared to 2020 state-of-the-art regional aircraft. A thermal engine that allows for usage of 100% sustainable aviation fuel, will allow to reduce lifecycle GHG emissions by 90% and thus close to zero. The proposed project AMBER (innovAtive deMonstrator for hyBrid-Electric Regional application) addresses this aspect and pursues the maturation of hybrid-electric key components and the validation of a product-representative parallel hybrid-electric propulsion system architecture, fuel cell based, for next-generation regional aircraft with EIS by 2035 to meet the ambitious environmental goals set out in SRIA and the Clean Aviation topic call.

Keywords: hybrid electric,propulsion system,engine,regional aircraft,fuel cell,sustainable,hydrogen,integration,fuel burn,electrical drive,controls,power distribution,certification,lh2,ghg
Lyric Poetry in Venice in the Heterodox Renaissance (1545-1657) (LyrPo)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-04-01
End date: 2029-03-31
Duration (months): 36.0
Total project cost (EUR): 396991.08
EU funding (EUR): 396991.08
Participants: 3
Project status: SIGNED

LyrPo will be the first comprehensive study of the impact of Protestant ideas on lyric poetry produced in Catholic Venice in the Tridentine and Post-Tridentine era. It will explore a significant aspect of the complex relationships between Catholics and Protestants of the time, during a period of censorship and mutual religious condemnation, by analysing an extensive corpus of lyric poems written in both Italian and Latin by a diverse array of women and men authors. The project will focus on an examination of those Venetian lyric texts that dealt with religion, morality, and politics, while variously expressing heterodox thoughts, which tended not to be overtly heretical (to avoid censorship), yet were subtly influenced by Reformation-inspired ideas. Protestantism was, indeed, present in Venice in the considered period. From the rise of the Reformation, the Republic of Venice was one of the Catholic states more open to Protestantism. It was also one which remained partially out of step with Counter-Reformation regulations up to the mid-seventeenth century, hence it remained somewhat more receptive to Protestant ideas for longer. Within this context, Reformation-inspired ideas informed and were reflected in literary works too, including lyric poems, which expressed heterodox thoughts in a wide gamut of ways. Studying what Protestant ideas were received, in which lyric texts, in what language, and by which authors is at the core of my research, which will combine and be built on the methodologies central to Literary, Gender and Reception Studies, and History of Religion and Ideas. In so doing, LyrPo will help to further our understanding of Renaissance literature, as well as the histories of lyric poetry, early-modern European culture, and the Christian Churches. Furthermore, it will challenge the commonly held assumption that the Post-Tridentine era was a homogeneous period during which dialogue between Catholics and Protestants was inhibited.

Keywords: lyric poetry,italian studies,venetian literature,renaissance literature,renaissance culture
HYdrogen DEmonstrator for Aviation (HYDEA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Aviation
Action type: Innovation actions
Partnership: CLEAN-AVIATION (JU-JTI)
Countries involved: Italy,France,Germany,Belgium,Ukraine,Netherlands,Switzerland,Poland,Türkiye
Call: Direct Combustion of Hydrogen in Aero-engines (HORIZON-JU-Clean-Aviation-2022-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 110587914.93
EU funding (EUR): 80495247.86
Participants: 32
Project status: SIGNED

The HYDEA project, which stands for “HYdrogen DEmonstrator for Aviation”, proposes a robust technology maturation plan to develop an H2C (Hydrogen Combustion) propulsion system compatible with an Entry Into Service of a zero-CO2 low-emission aircraft in 2035, consistently with the expected timeframe of the European Green Deal and CA SRIA objectives. The project aims to address fundamental questions related to the use of hydrogen as an aviation fuel, concentrating on the development and testing in relevant conditions of an H2 combustor and H2 fuel system, also including emission studies and further technologies which will serve as an outlook to future engines, i.e. NOx optimization studies, potential contrails emissions and investigating integration aspects between engine and aircraft. HYDEA results will be core for the ZEROe technology exploration project, launched by Airbus in 2020. The revolutionary technologies in scope call for an early engagement and dialogue with EASA (European Union Aviation Safety Agency) within HYDEA, starting from phase 1.

Keywords: hydrogen,h2 propulsion system,h2 engine,low emission aircraft,clean propulsion system,sustainable aviation fuels,non drop in fuels,efps,ground test,zero co2 flight
Decarbonising energy-intensive industries with renewable synthetic fuels (DESIRE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Belgium,Germany,France
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 4000622.4
EU funding (EUR): 4000622.4
Participants: 12
Project status: SIGNED

The future energy mix will include a variety of fuels. E-fuels allow to store the excess renewable energy into high energy-density chemical compounds representing the ideal candidates for energy transition in Energy Intensive Industries (EIIs). The DESIRE network will train the next generation of specialists in exploring the use of e-fuels, in existing combustion devices, to better guide the energy transition and to help the decarbonization of EIIs in Europe. The academic and industrial partners of DESIRE will work synergistically to generate a cohort of 15 well-trained young scientists with inter-disciplinary skills in combustion science, mechanical and chemical engineering, computer science and modelling that will be ready to propel and advance future engines towards pollution control, fuel-flexibility and higher efficiencies. Such a broad spectrum of training is currently lacking due to the fragmentation of the emerging field of sustainable combustion across Europe. Perhaps more importantly, the need, nature and magnitude of these new skills is only now emerging. The DESIRE network will equip its Doctoral Candidates with a unique combination of skills essential to become future research leaders or entrepreneurs in the sustainable energy sector. They will drive this research field forward and accelerate the energy transition. The main scientific goal of DESIRE is to develop predictive tools including mathematical-numerical models and experimental measurement techniques able to describe the combustion of e-fuels that can then assist engineers in designing new technologies and/or modifying/adapting existing combustion equipment and technologies to be suitable to use these powerful fuels. The program is heavily supported by key-companies in the transport sector (Rolls-Royce, Safran), fuel and chemicals production/ distribution (Air Liquide), and electrical/mechanical power technology (Condevo, ENGIE, MITIS).

Keywords: electrofuels,combustion fuel fexibility pollutant emissions chemical kinetics physical processes cfd,digital twins numerical models