Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Light-addressable potentiometric sensors (LAPS) for zinc imaging with high spatiotemporal resolution for elucidating the role of zinc in age related macular degeneration. (ZINCLAPS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-21
End date: 2019-08-24
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Light-addressable potentiometric sensors (LAPS) have great potential as a tool for functional electrochemical imaging of the attachment area of cells, providing information such as ion concentration, extracellular potentials and ion channel activity. The technique is particularly attractive for analysing cell responses of cells with planar polarisation as the cell-surface attachment area is not accessible to conventional electrophysiological measurements. However, current systems suffer either from poor resolution or slow scanning speed. In this project, we propose to develop a novel LAPS setup with high spatiotemporal resolution combined with two-photon fluorescence microscopy that allows imaging of physiological processes with submicron resolution and in real time. Novel zinc sensitive surfaces will be developed and used in conjunction with the new high-resolution and high-speed LAPS setup to investigate the role of zinc in age related macular degeneration (AMD). The retina and the underlying retinal pigment epithelium contain high concentrations of zinc. Several eye disorders are associated with altered zinc balance, and zinc supplementation has become a choice of treatment for diseases like agerelated macular degeneration. Despite its importance in health and diseases of the eye, it is still not well understood how zinc participates in cellular and molecular events and how zinc supplementation might be beneficial. We will investigate zinc fluxes at the basal side of the retinal pigment epithelium where zinc is suspected to play a key role in the formation of deposits and the initiation of AMD. The results of the study may lead to new treatments to prevent, forestall, or reverse the effects of the disease and may also help to elucidate zinc's role in other diseases including type 2 diabetes, pancreatic cancer, and Alzheimer disease and are therefore expected to impact the pharmaceutical industry and increase the quality of life for an ageing population.

Keywords: light addressable potentiometric sensors laps,zinc,imaging,impedance,retinal pigment,cells,age related macular degeneration amd
The Rise of Neoliberal Feminism (RNF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Focusing on neoliberalism's emergent feminist discourse in the UK and the US, I aim to provide a multi-dimensional theorization of this phenomenon. Two central questions inform this project: 1) Why does neoliberalism need feminism at this particular historical juncture in order to reinforce its hegemony? and 2) How and in what ways do certain themes of feminism lend themselves to the neoliberal project? Working on the seams of feminist theory, cultural studies and sociology, I will embark on a comparative study, examining one key but neglected site of neoliberalism's adoption of feminism: the discourse of a happy work-family balance. In order to accomplish this, I will employ a multidisciplinary methodological approach, combining textual and discourse analysis, qualitative data analysis and intersectional theorizing. My premise is that the resurgence of the work-family balance, which is being articulated as a feminist ideal, is the site through which the contemporary entanglement of feminism and neoliberalism is most clearly articulated. RNF therefore has four main interrelated objectives: to map the current resurgence of the work-family balance discourse in the mainstream print media in the UK and the US; to uncover the racial and economic underpinnings of this balance discourse; to analyse the new feminist subject this discourse is creating; and, finally, to build a theoretical framework that not only helps to explain why neoliberalism needs feminism at this historical juncture, but one that can help account for other contemporary alignments between feminism and neo-conservative and neoliberal projects in the broader European and Western context.

Keywords: feminism,neoliberalism,new feminist subject,work family balance discourse,professional women
Development of fluorescence nanospectroscopy to elucidate the roles of nanoscale molecular segregation in the activation of T-cells (FNS-4-NAMOSAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

BACKGROUND Nanoscale protein and lipid heterogeneities, e.g. lipid rafts, have been detected in numerous membrane-related cellular processes, including the initiation of the immune response upon T-cell activation. However, the interplay of protein and lipid segregation remains unclear. PROBLEM Super-resolution fluorescence microscopy can localize such supramolecular structures, but reveals little information on their identity. In contrast, (micro)spectroscopies with environment-sensitive probes can identify local molecular properties, but lack the appropriate spatial resolution for their localization. AIM The main research goal of the Action is to establish an original method with suitable resolution and sensitivity to improve our understanding of lipid reorganization during the activation of T-cells. SOLUTION We will develop fluorescence nanospectroscopy (FNS) by combining STED microscopy, spectral detection, and environment-sensitive probes, to achieve the sensitivity to local molecular properties with nanoscale spatial resolution. IMPACT Besides new insights into molecular mechanisms of immunity, FNS will importantly complement the available methods by probing local molecular order, facilitating FRET measurements, super-resolved spectral imaging etc. It will enable further advances in numerous fields of molecular and cell biology where membrane proteins and lipids act in a precisely coordinated manner. TRAINING The Researcher will be enrolled in the world-leading environment in the fields of STED microscopy, membrane structure and dynamics, and immunology. The acquired deep knowledge on the subjects of research, gained solid experimental and leadership skills from the Supervisor, invaluable experience from a cross-sectoral visit in the collaborating company, as well as his integration into the network within the scientific communities of planned multidisciplinary research activities, will decisively boost his future career as an independent life scientist.

Keywords: fluorescence nanospectroscopy,sted microscopy,super resolution fluorescence microscopy,spectral imaging,environment sensitive probes,membrane heterogeneity,lipid clustering,immunology,t cells
Tracking hydrothermalism in impact craters through rock magnetism on Earth and Mars (THIRST-MARS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-01
End date: 2024-12-31
Duration (months): 36.0
Total project cost (EUR): 257619.84
EU funding (EUR): 257619.84
Participants: 2
Project status: CLOSED

Impact cratering is a main geological process in the Solar System that can generate a conspicuous amount of heat and, in wet conditions, potentially favor hydrothermalism. The latter plays a key role in the mobilization of elements critical for the habitability of a planetary body and, can promote the formation of economic deposits. Over the last decades, the potential for impact craters to create favorable conditions for life, and the evidence of the past presence of liquid water on the surface of Mars, fed a growing interest in Mars impact craters exploration. Geophysics plays a critical role in the recognition of impact structures, particularly where we lack direct evidences. Gravity and magnetic observations, as testified by terrestrial impact craters investigations, are primary indicators of these structures and can be used to track physical changes induced by hydrothermal alteration. On Mars, while impact craters are well preserved, the spatial resolution of the geophysical data is limited by the satellite altitude, therefore the identification of areas of interest for impact-related hydrothermalism is challenging. This project aims to provide a new vector gradient based crustal magnetic model of Mars to better resolve geological features, e.g. hydrothermally altered zones within impact craters. However, magnetic data interpretation can be ambiguous and requires a solid knowledge of the variables controlling the magnetic properties of altered/unaltered impact craters rocks. The project aims to accomplish this knowledge with a multi-scale and multidisciplinary study of three selected terrestrial impact craters that experienced hydrothermal alteration. By investigating the magnetic signature of impact craters and by improving the resolution of the global magnetic crustal model of Mars, this project will provide a new tool to investigate the evolution of Mars, and to target areas of interest for future missions where to search for resources and traces of life.

Keywords: magnetic anomalies,rock magnetism,impact craters,hydrothermal alteration
Comparison of implicit and explicit learning abilities in human adults, children, apes and monkeys (ImpExpPrimates)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

Psychology of human learning distinguishes implicit learning, i.e. the incidental acquisition of unconscious knowledge, from explicit learning, i.e. the deliberate acquisition of conscious knowledge. Despite that a comparative and developmental approach is indispensable to better understand their conditions of emergence, functions and underlying mechanisms, the hypothesis of a similar distinction between implicit and explicit forms of learning in other species has been largely overlooked so far, and their ontogeny in humans is not fully understood. The present proposal offers to tackle this issue by assessing the hypothesis of a dual-process account of sequence and artificial grammar learning in a range of non-human primate species, and to trace its development from early childhood. For this purpose, we will adopt a novel approach by using non-verbal computerized tasks equally usable in human adults, children, and non-human primates. The proposed experiments rely on a well-established paradigm from the human literature, where a dissociation between implicit and explicit learning is evidenced by successful control over the expression of the acquired knowledge under conditions promoting explicit learning, and failure to do so under conditions promoting implicit learning. These studies will provide key data to characterize the relationships between learning and consciousness beyond the adult human mind, through the support of a leading expert in the study of conscious and unconscious processes in humans, Prof Jérôme Sackur (Ecole Normale Supérieure, France) and in collaboration with a renowned comparative and developmental psychologist, Prof Daniel Haun (Max Planck Institute for Evolutionary Anthropology, Germany). This interdisciplinary approach will be strengthened by initiating a collaborative research program aimed at exploring dual-process theories of cognition in a comparative and developmental perspective.

Keywords: learning,consciousness,dual process theories of cognition,artificial grammar learning,sequence learning,monkeys,apes,animal cognition,comparative psychology,children,ontogeny,development
Platform for Innovation of Procurement and Procurement of Innovation (PIPPI)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Coordination and support actions
Countries involved: Austria,Italy,Spain,Finland,Sweden,Netherlands,United Kingdom
Call: Digital health and care services – support for strategy and (early) adoption (H2020-SC1-DTH-2018-1, 2018)
Start date: 2018-12-01
End date: 2022-05-31
Duration (months): 42.0
Total project cost (EUR): 2996000.0
EU funding (EUR): 2996000.0
Participants: 10
Project status: CLOSED

The digital transformation of healthcare asks for the procurement of innovative solutions for which public-private collaborations are essential. These collaborations are often reactive and not fully connected with the needs and specifications of the healthcare professionals. To address this challenge, the demand side should be in the driver seat in innovation procurement for healthcare. Therefore, the PIPPI project will create a cross-border Community of Practice of European university hospitals that will bring together experts from the demand and supply side to identify common clinical needs for digital healthcare solutions and procurement of innovation knowledge. The consortium includes 7 major European university hospitals offering expertise on digital healthcare, patient-centered care and procurement with the ultimate aim to solve shared clinical challenges. The project will engage relevant stakeholders involved throughout the innovation procurement process at a regional, national and European level. The consortium with its network partners such as industry and payers of healthcare, will gather best practices, and develop structural capital and tools around procurement that will be shared through a knowledge brokerage platform on an European level by actors involved in, planning or interested in procurement of innovation. The consortium will identify major clinical needs from 10 university hospitals spread around Europe and compile a short-list of challenges that are suitable to solve with digital solutions and for procurement of innovation. This shortlist will be the base for a feasibility study and preparation of a concrete cross-border PCP. To secure the future use of project results, including long-term assessment and monitoring of outcomes, the PIPPI project will develop a business and implementation plan with the ultimate aim to improve patient outcome, decrease healthcare costs, create growth for European life science industry and create new markets.

Keywords: highly specialized care,pre commercial procurement,university hospital
Users, Safety, security and Energy In Transport Infrastructure (USE-IT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Ukraine,Austria,Germany,Spain,Lithuania,Poland,Sweden,Belgium,France,France,Czechia,Netherlands,United Kingdom,Portugal
Call: Next generation transport infrastructure: resource efficient, smarter and safer (H2020-MG-2014_SingleStage_B, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 955624.72
EU funding (EUR): 955624.72
Participants: 14
Project status: CLOSED

The transport network across Europe faces challenges relating to carbon reduction targets, energy security, and depletion of natural resources, without sacrificing its efficiency and compromising mobility. In addition, the road and rail infrastructure in particular are ageing and require renewal. Simultaneously, advances in sensors, mobile communications, smart ticketing and ‘big data’ offer the potential for customers to become an active part of the transport operations system and have the information to make decisions – for transport to enable ‘mode agnostic’ personal and business travel and – for freight operators to have more resilience and better reliability in their systems. The European transport system faces also an unavoidable societal challenge, which is achieving new levels of resource-efficiency, environmental-friendliness, safe and seamless transport for the benefit of citizens, the economy and society. In order to tackle the challenges and reap the benefits outlined above, infrastructure owners and transport operators will be required to work together, along with other crucial stakeholders, to share knowledge and cooperate in a way that will be beneficial to all parties, and this proposal seeks to facilitate this. The objective of this project is to better understand the common challenges experienced across transport modes, bring representatives of transport modes together to share experience and skills and to develop a set of common research objectives. The project will draw upon the experience gained from the Joint European Transport platform with the focus on infrastructure operations, and will also focus on research objectives presented in the Forever Open Road programme and the work of the FORx4 - Forever Open Road, Railway, Runway and River – A Cross-modal transport initiative for research for which FEHRL produced a ‘Point of View’ document.

Keywords: cross modal infrastructure,co modal transport research,multimodal interaction,mobility in the 21st century,transport modes,safety and security,energy and carbon
Human Rights in the Post-Uprisings Middle East: Emerging Discourses and Practices in Egypt and Tunisia (HURIME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The popular Arab Spring uprisings in the MENA (Middle East and North Africa) region and their recent developments have proved the significant emancipatory potential of human rights and moved the human rights issue to the forefront of academic and political debates. This project deals with the human rights discourses and practices in the MENA region undergoing transition through the course of so-called Arab Spring by conducting a comparative analysis of two key countries; namely Egypt and Tunisia. The project has three main objectives. First, it aims to provide an in-depth knowledge of the characteristics and developments of human rights in the region. Second, it strives to explore the main political and social conditions that constitute the shift and persistence in the discourses of human rights. Third, it aims to explore the impact of the shift and persistence in human rights discourses on the actual practice of human rights in the region, with the ultimate aim of identifying the best ways for improving human rights practice in the region. To achieve the objectives of the project: First, in-depth analysis of primary and secondary sources will be conducted to discover the main patterns and characteristics of the emerging human rights discourses in post-uprising Egypt and Tunisia. Second, political, legal and social conditions influencing the human rights discourses will be explored by looking comparatively at situational variables.Third, the impact of the shift and persistence in the discourses on the human rights practice will be explored by comparatively examining the human rights situation in the post-uprising countries. The project will enhance the knowledge of academicians and politicians on the new tendencies of human rights discourses and practices in the region and will offer a valuable insight into the main patterns and political conditions of emerging human rights discourses and practices.

Keywords: human rights,middle east and north africa,egypt,tunisia,discourses
From biomass to catalysts and chemicals: exploiting blood and food waste towards high-value products. (HAEMOGLOBIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-10
End date: 2022-06-09
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The aim of this proposal is to make universal and low-cost catalysts from industrial waste and apply them to biomass upgrading. To that end, we will make single atomic FeNx sites supported on carbon (FeNx@C) that have seen tremendous development in organic chemistry in the past 5 years. Indeed, they are active for both oxidations and reductions, and constitute promising substitutes for toxic, scarce and costly platinum-group metals (PGM). Yet major challenges remain in the field: first we need to find new routes to drastically lower the footprint of their synthesis. Here we will adopt a bio-inspired approach and use inexpensive hemoproteins as precursors: they naturally contain four pre-built FeNx sites (hemes) per unit. Hemoproteins can be extracted from blood in slaughterhouse waste. We will use the resulting catalysts for the upgrading of key biomass-derived platform molecules: 5-hydroxymethylfurfural (5-HMF), levulinic acid (LA), and other biomass-derived alcohols. The reductive and oxidative potency of FeNx@C will be first explored separately, then sequentially for alcohol direct conversion to amines. Due to their heterogeneous nature, FeNx@C catalysts can be readily transposed to continuous flow synthesis. With such promising technology, we will fully exploit biomass to both make new catalysts and perform large scale conversion of bio-based platform chemicals.

Keywords: single site catalysis,biomass conversion,flow chemistry