Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Novel applications of renewable based molecules for the production of cyclic carbonates and polycarbonates (RENOVACARB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-03-01
End date: 2016-02-29
Duration (months): 24.0
Total project cost (EUR): 166336.2
EU funding (EUR): 166336.2
Participants: 1
Project status: CLOSED

Metal and organo-catalysed carbon dioxide (CO2) fixation is a feasible strategy for the preparation of new and sustainable chemical synthons and materials. The RENOVACARB project aims at preparing novel cyclic carbonates and polycarbonate based materials exploiting carbon dioxide conversion reactions on easily obtainable renewable-based compounds, most of which have never been used for this purpose before. Project development will focus on the overall process sustainability: (a) developing new environmentally friendly transformation protocols; (b) selective CO2 cycloaddition/alternate condensation reactions for the preparation of novel renewable-based cyclic and (poly)carbonates; (c) designing novel and simplified catalytic one-pot CO2 conversion protocols for non-functionalized renewable-based molecules; (d) preparing novel structural complex polycarbonates by alternate CO2 polycondensation reactions with renewable-based synthons blends. The resulting molecules and materials will be characterized and evaluated for practical applications. RENOVACARB is designed to develop simple and feasible strategies for renewable resources exploitation by incorporation of CO2 into added value molecules and materials, offering tangible alternatives to petroleum derived feedstocks. RENOVACARB will provide Dr. Giulia Fiorani, Experienced Researcher with a long lasting interest in sustainable chemistry and new material development, with specific technical training and project managing expertise, integrated with complementary added-value non-scientific skills, for a holistic approach to further academic career development. The Experienced Researcher will also have the possibility to work at ICIQ, a distinguished and internationally renowned European centre of excellence for Renewable Energies & Catalysis, under the supervision of Prof. Arjan W. Kleij, an international renowned expert in sustainable, carbon dioxide fixation protocols and development of functional (polymer) materials.

Keywords: renewable bioresources,sustainable chemistry,catalysis,cyclic carbonates,polycarbonates,selective transformations,organocatalysis,material science
Beta-cell Receptors in Diabetes Therapy (BRIDIT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-03-31
End date: 2016-03-30
Duration (months): 24.0
Total project cost (EUR): 231283.2
EU funding (EUR): 231283.2
Participants: 1
Project status: CLOSED

This Fellowship combines the expertise of the host group in the expression and function of islet G protein-coupled receptors (GPCRs) with the Fellow’s previous experience in identifying the role of retinoic acid and neurotrophin receptors in islet function. GPCRs are the targets of up to 50% of all prescription drugs and Byetta, a GLP-1 receptor activator used to treat Type 2 diabetes (T2D), provides proof of concept that ligands targeting islet GPCRs may be developed for T2D therapies. However, Byetta has been associated with pancreatitis and kidney dysfunction, so there is a need for novel T2D therapies with minimal side-effects. There are over 50 million people in Europe with T2D, which arises when insulin secretion is unable to compensate for insulin resistance in target tissues. Agents that increase insulin secretion and/or stimulate b-cell proliferation will have beneficial effects in T2D where insulin secretion is compromised through impaired stimulus-secretion coupling and/or reduced b-cell mass. This Fellowship project has two main objectives: Investigating the role of islet short chain fatty acid receptors (FFAR2 and FFAR3) in regulating beta-cell function and identifying novel islet GPCRs that regulate insulin secretion and/or beta-cell mass. The host lab has identified expression of FFAR2/3 by islets and the Fellow will determine whether they have therapeutic potential for the treatment of T2D. In addition, orphan GPCR beta-arrestin reporter cell lines will be used to detect activating ligands secreted by islets and functional effects of those orphan GPCRs will be established following knockdown of their expression. This is an ambitious project that has the potential to provide drug discovery leads for T2D therapies. The Fellow will benefit from training in state of the art islet biology methodologies in an internationally acknowledged environment for diabetes research, which will facilitate his transition into a fully independent research scientist.

Keywords: g-protein coupled receptors,beta cells,islets,insulin,diabetes
Interests, demands and network ties in Brussels: explaining interest groups' lobbying success across EU policy areas. (EULOBBYING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-09-01
End date: 2016-08-31
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

The project aims to examine interest groups’ participation in EU policymaking and to investigate a fundamental question regarding the EU interest representation system: under what conditions are interest groups’ policy demands integrated into the policymaking process and translated into policy outcomes? In other words, what factors explain interest groups’ success in influencing the content of EU legislative proposals?The project aims to answer this question by examining interest groups’ lobbying during the policy formulation and policy shaping stages of the EU policymaking process and focuses on lobbying in the European Commission and the European Parliament, across four policy areas.To explain lobbying success the project will elaborate and empirically test an explanatory framework that emphasizes the importance of the policy context in which lobbying takes place. This context is defined in terms of: characteristics of policy issues; the aggregate distribution of interest groups’ policy demands; and the policy network ties established between interest groups themselves and interest groups and policymakers. The project proposes a research design that allows a systematic, empirical testing of the theoretical framework with the help of multi-level statistical models and social network analysis.The project addresses and contributes to the scholarship on EU lobbying, policymaking and decision-making processes. Theoretically, the project innovates by proposing an explanatory framework that emphasizes the relational environment established both among interest organisations themselves, and among organisations and policymakers, and the aggregate distribution of demands articulated by interest groups.These dimensions have not been systematically studied in the literature at policy issue level.Methodologically, the project innovates by adopting an original research design that allows a disaggregate empirical investigation of interest groups' demands in the EU policymaking.

Keywords: eu lobbying,interest groups,lobbying success,demand attainment,european commission,european parliament,policy demands,policy networks,statistical analysis,social network analysis.
Effects of Mediterranean desert dust outbreaks on radiation, atmospheric dynamics and forecasting accuracy of a numerical mesoscale model (MDRAF)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-05-01
End date: 2016-04-30
Duration (months): 24.0
Total project cost (EUR): 166336.2
EU funding (EUR): 166336.2
Participants: 1
Project status: CLOSED

The main objective of the proposed project (MDRAF) is to describe the 3D structure of Mediterranean desert dust outbreaks and study their effects on radiation and atmospheric dynamics by means of numerical modeling (NMMB/BSC Chemical Transport model-NMMB/BSC-CTM). Moreover, the meteorological feedbacks and the forecasting accuracy of NMMB/BSC-CTM when dust effects are considered will be assessed. The study region covers the broader Mediterranean basin and the analysis extends over the period 2002-2012. For the identification of desert dust outbreaks, an objective and dynamic algorithm will be set up where as initial conditions various aerosol optical properties derived by MODIS-Aqua, EP-TOMS and OMI platforms will be used. Additionally, satellite (CALIPSO) and ground (EARLINET) measurements providing the vertical profile of dust loads will be also analyzed. The accuracy of algorithm’s outputs will be evaluated against optical (AERONET) and physical (PM10) measurements. At the next step, the direct radiative effect (DRE) will be estimated at the top of atmosphere, into the atmosphere and at surface for the shortwave (SW), longwave (LW) and net (SW+LW) radiation. The induced radiative effects are expected to affect the vertical atmospheric heating profile leading to a modification of the atmospheric dynamics. For this purpose, it will be studied how dust DREs affect the temperature vertical structure, the surface temperature and sensible/latent heat fluxes, stability/instability conditions, the convective available potential energy (CAPE), clouds and precipitation formation. Also, the possible feedbacks induced by dust particles affecting thus their production/removal rates as well as the atmospheric circulation patterns related with their transport processes will be also examined. At the final stage of the project, the forecasting accuracy of the NMMB/BSC-CTM will be examined for several atmospheric parameters, locally and spatially, when dust effects are considered.

Keywords: satellite,dust,mediterranean,modeling,atmospheric dynamics,radiative effects,optical properties,feedback mechanisms,radiation,climate,dynamic meteorology,synoptic meteorology,nmmb/bsc-ctm
The most cosmopolitan animal migration: phylogeography and population genomics of the butterfly Vanessa cardui (MIGRATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2015-02-01
End date: 2018-01-31
Duration (months): 36.0
Total project cost (EUR): 254474.1
EU funding (EUR): 254474.1
Participants: 1
Project status: CLOSED

The migratory strategy is an evolutionary response to heterogeneity in either time or space that is common in animals, including many insects. The dispersal of myriads of insects has relevant economic consequences with examples including the pollination of agricultural systems, the association with pest outbreaks and the spread of infectious diseases. The case of the butterfly Vanessa cardui is an ideal model to study population dynamics of insect migrations because the species is distributed worldwide, it does not perform diapause and is extremely polyphagous. While this cosmopolitan butterfly represents what is potentially the widest distributional range of any migratory species, its migratory behavior is poorly known. In this project I propose to perform a comprehensive study of V. cardui genetic population structure, including an analysis of its worldwide migratory routes, the genetic causes and consequences of migration, aspects of the physiology of its migratory habits and possible outcomes of future climatic changes. This multidisciplinary project will involve the use of new technological and theoretical advances in next-generation sequencing, genomic analysis and coalescent-based phylogeography. The exceptional amount of specimens and data that will be assembled will represent a precious resource for future research on population genetics and ecology. Given the biological traits of this remarkable animal, results will have a strong impact and will attract the attention of researchers from different disciplines, and V. cardui will emerge as a model organism for the study of worldwide migrations.

Keywords: population genetics,phylogeography,animal migration,next-generation sequencing,genomics,biogeography,macroecology,climate change,insect ecology,evolution,vanessa cardui.
The Governance Capacity of Cooperative Housing: The Role of 'Linking Social Capital' (COOPERATIVECAPITAL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2015-01-19
End date: 2017-01-18
Duration (months): 24.0
Total project cost (EUR): 221606.4
EU funding (EUR): 221606.4
Participants: 1
Project status: CLOSED

Cooperative initiatives in the field of housing are considered increasingly important for fostering social cohesion in European city regions. Nevertheless, the debates on the potential of third sector housing in different EU member states are currently only weakly connected. It is therefore crucial to inform these debates with timely academic research that is accessible to policy makers and practitioners in Europe. Against this background, the principal aim of the proposed project is to investigate how different governance models of housing cooperatives influence the creation of 'linking social capital'. Applying qualitative, case-study oriented research, a comparative study between the Vienna city region and the West Midlands region in England will derive conclusions on the design of governance institutions in cooperative housing which foster linkages between residents, housing managers and people in positions of influence and power in the external institutional environment. Given the high expectations of policy makers and academics towards third sector housing, the project provides a more realistic picture of cooperative housing governance and its capacity for influencing cohesive urban development through community empowerment. The proposed project is highly relevant for the European Research Area because it deepens the inter-European dialogue on the role of third sector housing for social cohesion. Furthermore, it aims at achieving a better mutual understanding between different regional schools of thought within Europe. The fellowship will also enhance the academic career prospects of the experienced researcher through advanced training in qualitative organisational research methodology and in European housing policy. The two years intensive training in a high quality academic environment will guarantee a standard to secure publication in the highest ranking English language peer review journals and should lead to a permanent faculty position.

Keywords: social housing,third sector housing,housing cooperatives,social cohesion,social capital,governance
Research of new marine inhibitors targeted against desease-relevant proteins kinases (OCEANCHARCOT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-06-24
End date: 2017-06-23
Duration (months): 36.0
Total project cost (EUR): 279172.5
EU funding (EUR): 279172.5
Participants: 1
Project status: CLOSED

Project OCEANCHArCoT – OCEAN CHemodiversity Against Cell cycle Targets. Protein Kinases (PKs) are involved in various human pathologies such as cancer, neurodegenerative diseases or can be targeted to alter the life cycle of various parasites such as those responsible neglected parasitic diseases such as leishmaniasis and malaria. There are no physiological events not involving significant changes in protein phosphorylation. Therefore, PKs constitute currently the first class of targets used by pharmaceutical companies for the characterization of novel bioactive compounds. In a project intended to exploit the ocean biodiversity, Jean-Baptiste Charcot (1867-1936), a pioneer in oceanography established large collections of marine organisms. Taking this one step further, my project aims to source marine crude extracts from the Nature Bank collection (Queensland, Australia), and from the unique Roscoff Culture Collection of microalgae (France) to identify new PK inhibitors. We will focus our analysis on PKs involved in the control of the cell division cycle (CDKs, TLKs and mitotic kinases such as Haspin and Auroras). The cellular effect of the selected inhibitors will be analysed on various cancer cell lines. This project will benefit from a new cutting edge technology will be used for the early screening of marine chemodiversity: bioaffinity (focused on PKs) mass spectrometry with a Bruker SolariX 12 Tesla FTMS. The lead-like enhanced fractions will be tested against various disease models and dereplicated in order to quickly identify bioactive molecules. Hit fractions will be produced in larger quantity before purification, characterization and pharmacological evaluation. In conclusion, OCEANCHArCoT will contribute, from Australia to France, to the research of marine bioactives to discover new therapeutic avenues to fight growing medical and social burdens such as cancer and Alzheimer’s disease.

Keywords: collection of marine extracts,inhibitors,protein kinases,high-throughput screening,bioaffinity mass spectrometry,dereplication,metabolites,marine chemodiversity,pharmaceutical ingredients.
The active pupil: The role of pupil size in active vision (ACTPUP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2013-IEF, 2013)
Start date: 2014-11-01
End date: 2016-10-31
Duration (months): 24.0
Total project cost (EUR): 194046.6
EU funding (EUR): 194046.6
Participants: 1
Project status: CLOSED

The pupil is a volatile surface. It shrinks when we step out into the sun, and expands when we get aroused or exert mental or physical effort. These basic pupillary responses have been recognized at least since Roman times, and have been the focus of systematic investigation since the 18th century. Currently, pupil-size measurement, or pupillometry, is an established tool for diagnosing visual defects, and is widely used as a marker of arousal or effort in psychological experiments and clinical applications Yet our understanding of pupillary responses is still largely descriptive: It is clear that arousal triggers pupillary dilation—but why? The pupil clearly constricts in response to light—but how is the light response linked to visual perception and cognition? These questions have so far received little attention. Yet they are crucial, not only to our understanding of pupillary responses, but to our understanding of visual perception in general. The purpose of the present proposal is to study pupillary responses from a cognitive-neuroscience perspective. We aim to understand how pupil size interacts with cognitive factors such as visual attention and awareness, and how pupillary responses help us to perceive the environment more clearly, or rather more adaptively. We will employ a multidisciplinary approach, in which we use behavioral eye-tracking experiments, informed by insights from neurophysiology, and formalize our results through computational modeling. Our main thesis can be summarized as follows: Pupillary responses are part of active visual exploration and reflect the demands of the environment as well as the cognitive state of the organism. This project is a collaboration between Dr. Sebastiaan Mathôt (applicant, Netherlands) and Dr. Françoise Vitu (scientist in charge, France), director of the Attention and Perception group at the Laboratoire de Psychologie Cognitive, Aix-Marseille Université.

Keywords: cognitive neuroscience,pupillometry,eye movements,experimental psychology,computational modeling,visual perception
Understanding human cooperation with humanoid robots: analysis from a social psychological perspective. (HUMROBCOOPERATION)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2013-IOF, 2013)
Start date: 2014-06-01
End date: 2017-05-31
Duration (months): 36.0
Total project cost (EUR): 328418.7
EU funding (EUR): 328418.7
Participants: 1
Project status: CLOSED

The aim of this project is to understand better people’s social interaction with humanoid robots to predict humans’ willingness to cooperate with them. Specifically, in the outgoing phase, the project examines whether (a) the predisposition to cooperate with other humans, (b) the influence of positive or negative information about the robot on impression formation, (c) the type of causal attribution: personal vs. situational, of robots’ actions, and (d) perspective-taking through robotic embodiment controlled by a brain-computer interface, can help predict cooperation with humanoid robots. In the return phase, the project (e) analyzes whether perceived body ownership with respect to robotic embodiment influences willingness to cooperate, and (f) explores willingness to cooperate with humanoid robots in extreme situations using Virtual Reality (VR). The practical implementation of the project will be through experimental research comprehending a total of six experiments involving human-robot interaction. The project addresses people’s understanding of robots from an innovative perspective by applying the principles of social perception theories to predict human cooperation with a robot. The results will contribute to a better understanding of the variables influencing human cooperation with humanoid robots and the consequences of the cutting-edge research field of embodying people in robotic bodies physically present in a remote location. In addition, the results are expected to provide valuable information for engineers and designers to help build robots with higher capabilities of predicting human behaviour and with higher social acceptance. Potential activities in which humanoid robots might be applied include rescue actions, hazardous operations, or assistance of elderly and people with disabilities, among others. Understanding human factors influencing cooperation with robots is fundamental for a successful implementation of these machines into society.

Keywords: human-robot interaction,humanoid robots,robotic embodiment,cooperation,social perception,media psychology,social psychology,social neuroscience,virtual reality