Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Engineering the Origin of Human Shape: Defining Patterns and Axes in the Early Stage of 3D Pluripotency (OriSha)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 1499633.0
EU funding (EUR): 1499633.0
Participants: 2
Project status: SIGNED

How an organism takes shape is a longstanding challenHow an organism takes shape is a longstanding challenge in modern biology and medicine. Understanding how, during the 3D embryo development, different molecular players, such as genetic programs, morphogens, and forces work together to build the shape of the body is still far to be understood, especially for humans. In recent years, some progress has been made to understand the inaccessible state of human development through models of human embryos derived from pluripotent stem cells. Although they brought very exciting findings, this approach failed in reconstructing the dynamic of the proper axes formation and 3D spatially ordered structure of tissues. OriSha will provide a ground-breaking technology to control over time and space the early stage of human shaping by modulating in an in vitro model the biochemical and biophysical properties of the microenvironment. I will develop a hydrogel-microfluidic system to accurately and dynamically deliver liquid instructive signals coupled with 3D shape-controlled organoid technology to guide the geometry during morphogenesis and recapitulate the very early and inaccessible stages of human embryo development. With this technological approach, I will instruct gradients of signalling molecules by imposing morphogens into the targeted tissues with unprecedented temporal and spatial resolution. To demonstrate the unique potential of this approach I will focus my interest on the development and morphogenesis of the neural tube that is the primordium of the central nervous system. Thanks to my cutting-edge approach, for the first time I will have the opportunity to investigate the correlation between the spatio-temporal dynamics and the 3D tissue patterning and self-organization during human embryonic development. The proposed project has the potential to become the new gold-standard for in vitro human developmental modelling, completely overcoming the need of human embryos.
Single-cell sequencing analysis of striatal gene regulatory networks in Parkinson's disease (PARKSEQ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: CLOSED

Parkinson’s disease (PD) is the fastest growing Neurodegenerative disorder, currently affecting an estimate of 7 to 10 million people worldwide. The disease is characterized by the loss of dopaminergic neurons in the substantia nigra and the accumulation of protein aggregates in the remaining ones. The loss of these cells leads to a dopamine deficit in the striatum which causes the motor symptoms characteristic of PD and the general malfunction of the neuronal circuitry in the basal ganglia. The existing treatment for PD is dopamine replacement therapy with levodopa. This drug alleviates the motor symptoms but has a number of side effects, loses efficacy with time and does not address the cognitive decline caused by PD. In order to gain a better understanding of the disease and open new paths towards an effective treatment, the PARKSEQ project will use the latest advanced in single-cell RNA sequencing and in situ hybridization to determine which cell-type specific gene regulatory networks (GRNs) are affected by PD in the striatum. To this end, I will use single-cell RNA sequencing (scRNA-seq) to study post-mortem human striatum samples from PD and control subjects, under the supervision and guidance of Ana Muñoz, a leading expert in PD and scRNA-seq studies. I will draw from my experience in Bioinformatics and in single cell data analysis to determine the cell types and subtypes existing in the human striatum. On each subtype, I will establish which genes are differentially expressed and, considering their co-expression, I will formulate putative altered GRNs. Then, during a secondment period, I will join Mats Nilsson laboratory to validate the scRNA-seq findings using in situ hybridization. Dr. Nilsson has advanced this technique making it possible to use verify the presence of over 100 genes simultaneously on intact tissue slices. This will enable me to verify the PD-induced alterations in the GRNs suggested by the scRNA-seq data.
Enabling safe & secure modular UPdates, UPgrades and DynAmic Task reallocation and Execution for Software Defined Vehicles (UP2DATE4SDV)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Research and Innovation actions
Partnership: CCAM (co-programmed)
Countries involved: Germany,Spain,France,Austria,Romania,Türkiye,Italy
Call: Centralised, reliable, cyber-secure & upgradable in-vehicle electronic control architectures for CCAM connected to the cloud-edge continuum (CCAM Partnership) (HORIZON-CL5-2024-D6-01, 2024)
Start date: 2025-07-01
End date: 2028-06-30
Duration (months): 36.0
Total project cost (EUR): 5999076.9
EU funding (EUR): 5999076.9
Participants: 14
Project status: SIGNED

UP2DATE4SDV has brought together automotive hardware manufacturers, the automotive software industry and SMEs, and the best-known researchers in the field to jointly create a comprehensive ecosystem for updatable, upgradable, and reconfigurable software-defined connected and automated vehicles. To this end, a middleware solution is to be created and integrated into the current automotive open source standards, which allows complete abstraction not only of the software running in the vehicle, but also of the installed hardware. As a result, not only can the software be continuously updated over the air over the lifetime of the vehicle and thus kept safe, secure, and up to date, but hardware components can also be easily replaced or supplemented to meet future requirements. To achieve this, we will additionally develop a new hardware component based on established automotive systems, which will be expanded in such a way that the unavoidable overhead resulting from the update capability of the systems is minimised thanks to explicit hardware support. The overall solution is suitable for the upcoming zonal E/E architectures that have a permanent connection to the cloud. The project therefore aims to develop and integrate methods that ensure the safety of the systems during an update by strictly separating all individual automotive applications in containers. In addition, a security layer will be introduced to prevent attacks via the cloud link or among the application modules. Finally, we want to make it easier for automotive software developers to use our middleware by establishing a reference layer based on a hypervisor that prevents the real-time requirements of different application modules from influencing each other. Communication to the vehicle components and to the cloud is abstracted and standardised. In addition, methods are provided to automate the V&V process for each further update, upgrade or reconfiguration and to ensure security at every step.

Keywords: ccam,sdv,updates,upgrades,safety,security
FORGED MEMORIES: the Church of Late Antique Iran and the West. The Textual Construction of a Relation with the Western Church and State Through Hagiographies, Epistles, Documents (4th-5th century) (ForM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States,France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 265099.2
EU funding (EUR): 265099.2
Participants: 3
Project status: SIGNED

According to a number of sources of diverse typology and different historical reliability - hagiography, historiography, epistles, ecclesiastical documents -, the Church of the Late Antique Iran, also known as "Church of the East", turned to the West searching for political support and ecclesiastical legitimation. In these sources, "West" is to be understood as a composite reality, including both the Roman political power, often represented through symbolic, even salvific, figures (Constantine, Helena), and the entire Church located west of the Iranian state. This search for diplomatic pressure from the Roman State and hierarchical legitimization from the "western" Church particularly took place during the 4th-5th century, a period in which the Church of Iran bloomed as an autonomous entity, but nevertheless a religious minority, persecuted from time to time by the Sasanian authorities. Through the edition of unpublished documents and the investigation about the reliability of known ones, the project aims at analyzing the circumstances and reasons of this longed-for intervention of the Western Church and Roman political power in both the dramatic circumstances of the persecution of Christians in the Sasanian Empire and the internal problems of the Church of East itself: to what extent and in what way does the ideological and literary re-elaboration affect the representation of this relation? What are the narrative devices adopted, and what is the role of some forged documents in that? In particular, the internal hierarchical controversies on the Patriarchal authority should receive new light through the online edition, translation, and analysis of a probably fake epistolary attributed to the 4th century Seleucian patriarch Papa Bar Aggai, that is, eight letters exchanged with exponents of the Western political and religious panorama (among them, e.g., Helena mother of Constantine).

Keywords: eastern christianity syriac studies late antique history hagiography church history christianity in iran religious minority church in a non christian political contex political theology
THE PLANT’S INTERNAL CELLULAR SENSING AND RESPONSE MEASURES TO MECHANICAL BREACH (PREENER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden,Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2025-04-30
Duration (months): 28.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 2
Project status: CLOSED

Plant-parasitic nematodes are microscopic organisms with exceptionally broad host range that pose major challenge to global agriculture, generate a predicted loss of 12.3 percent, equivalent to $157 billion each year. The losses caused by nematodes are further enhanced when they form disease-complexes with other microbes. Endoparasitic cyst nematodes are one of two most devastating groups, infecting the roots of economically important plants. The nematodes are a persistent problem because they have evolved an ability to secrete specific proteins to exploit the host plant’s development and suppress defense responses triggered by the plant. They begin feeding only after developing a specialized feeding structure (syncytium) inside the host root, by selecting a single cell near the innermost nutrient-rich vascular tissues, causing cellular injury by passing through multiple layers of different cell files. The majority of previous research has been on syncytium formation as infection proceeds. However, it is unknown how plants respond at the cellular level to the mechanical damage caused by nematodes, which prevents the creation of resistant plants to minimize crop losses. In the proposed study, cells from two internal consecutive cell layers surrounding the vascular tissues will be studied for their molecular responses to mechanical injury. The control of lignin and suberin production, which function as physical barriers against invading pathogens, will be studied in particular. Advanced microscopic technology will be utilized to accurately produce mechanical damage in selected internal root cells using a cutting-edge method called laser ablation. It will offer a strong platform for the creation of resistance agricultural plants against plant parasitic nematodes in the long run. The project will use a variety of high-tech multidisciplinary approaches to provide a framework for researching plant physical barrier measures against invasive plant diseases.

Keywords: plant nematode interaction,mechanical injury,lignin,suberin,cellular responses,laser ablation
Chemistry under Force (ChemForce)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and Analytical Chemical Sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Belgium
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 2496838.0
EU funding (EUR): 2496838.0
Participants: 1
Project status: SIGNED

During the last three decades, physicists and biophysicists have largely exploited single-molecule force spectroscopy (SMFS) to advance many fields of physics, nanotechnology, and biology. The ability to probe one molecule at a time allows us to ask and answer questions that are impossible, or extremely difficult, to approach by ensemble techniques. Chemists did not fall into steps behind physicists and biologists and have benefited little from the advent of SMFS. The mechanics of bonds, which is still in its infancy, could largely benefit from SMFS. A big question like how forces and chemistry affect each other? merits special attention. Major questions, especially concerning the mechanical reversibility of bonds and bond lifetime under tension, could be elucidated. Over the last years, my group has acquired the needed expertise and has developed a range of pioneering SMFS approaches that now allow us to tackle this big question requiring a considerable joint effort between synthetic chemists, chemical physicists and engineers. The extreme difficulty to probe bond reformation after its rupture has been a major failure of SMFS for the last 25 years. We propose here to solve this problem and adapt SMFS to obtain a detailed picture of the mechanics and reversibility of bonds. We will design, synthesize and probe a series of supramolecular and (dynamic) covalent tethered bonds in various geometries and chemical environments. The tethered structure will ensure that the partners of the bond stay in close proximity after being broken open, leaving the possibility of rebinding. This will offer remarkable opportunities to investigate in detail how mechanical forces and proximity can trigger chemical reactions. If we wish to gain a deeper understanding of how forces and chemistry affect each other and open new possibilities for chemical synthesis and materials science, the development of SMFS adapted to detailed chemistry investigations remains a frontier to be conquered.

Keywords: single molecule force spectroscopy atomic force microscopy optical tweezers mechanics of bonds single molecule mechanochemistry
AGPs roles in Arabidopsis fruit development (FruitAGPs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-07-01
End date: 2028-06-30
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

By 2050, the global population is projected to reach approximately 9.7 billion, adding significant pressure on the world's food production systems. This global population increase will require a substantial improve in food supply, including fruits, which are essential for human nutrition. To understand the fundamental molecular mechanisms related to the fruit development is extremely important for increasing crop productivity and high-quality fruit and seed production. Furthermore, the knowledge acquired in this process will be important for developing fruit crops resilient to changing climates, meeting this demand sustainably and ensuring food security. FruitAGPs aims to provide new insights into the role of Arabinogalactan Proteins (AGPs), cell wall glycoproteins crucial for plant growth and development, and their putative transcriptional regulation in fruit tissues providing crucial knowledge about their functions in these tissues. This will be achieved using a combination of cutting edge genetic, proteomic and molecular biology approaches in Arabidopsis thaliana. Both the host laboratory and researcher stand to benefit from FruitAGPs, as it bridges two distinct molecular research fields focused on the same developmental process: fruit development.

Keywords: arabidopsis arabinogalactan proteins fruit development transcription factors
Illicit labour: Unveiling the dark sides of the global photovoltaic industry (illicitLABOUR)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: United Kingdom,Italy
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2024-02-01
End date: 2029-01-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: SIGNED

illicitLABOUR pioneers a study of the linkages between climate change mitigation and illicit economies and the resulting implications for ecological governance. This comparative and interdisciplinary project goes beyond the current state-of-the-art research in three significant ways. First, by investigating global photovoltaic industry production networks it reveals the dark sides of the green energy sector in three geographical sites (China, Ghana, and India). Second, it advances new theoretical perspectives on risk, vulnerability, and mitigation considering the interplay between the green energy sector and the illicit economy. Third, it attempts a transformative breakthrough by developing a ‘cultural political ecology’ framework that brings cultural economy and political ecology together, pushing labour studies frontiers forward. The research will focus on several core questions: How do we explain the economic, political, and cultural processes linking illicit labour and ecological governance? Which illicit labour regimes in mining and manufacturing processes sustain solar panel production? How do informal energy markets work? What are the social and environmental challenges raised by end-of-life photovoltaic modules? How can we understand the illicit-ecology nexus in light of these processes? And, finally, how can this analysis reveal new ways to provide clean and affordable energy for all? Climate change mitigation and illicit labour are two major challenges of modern times, whose interconnection poses growing concerns for society, such as energy insecurity, toxic waste production, and labour exploitation. Yet this relationship has surprisingly received limited systemic attention in labour studies to date. Through an analysis of the global photovoltaic industry, a major climate change mitigation sector, illicitLABOUR casts light on those neglected actors, practices, and processes that operate in the shadow of sustainable development.

Keywords: climate change mitigation,global production networks,illicit labour,informal economy,cultural political economy,political ecology,economic geography
Promoting disaster preparedness and resilience by co-developing stakeholder support tools for managing the systemic risk of compounding disasters (PARATUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Disaster-Resilient Society for Europe
Action type: Research and Innovation actions
Countries involved: Netherlands,Romania,Türkiye,Austria,Italy,Poland,Germany,Thailand,United Kingdom,Spain
Call: Enhanced assessment of disaster risks, adaptive capabilities and scenario building based on available historical data and projections (HORIZON-CL3-2021-DRS-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 4701636.25
EU funding (EUR): 4701636.25
Participants: 19
Project status: SIGNED

The ongoing pandemic and climate crisis have taught us hard lessons about the systemic impact of compounding disasters. Stakeholders in disaster risk management are faced with the challenge to adapt their risk reduction policies and emergency plans but lack the tools to account for the cross-sectoral impacts and dynamic nature of the risks involved. The PARATUS project aims to fill this gap by developing an open-source platform for dynamic risk assessment that allows to analyse and evaluate multi-hazard impact chains, risk reduction measures, and disaster response scenarios in the light of systemic vulnerabilities and uncertainties. These services will be co-created within a unique transdisciplinary consortium of research organisations, NGOs, SMEs, first and second responders, and local and regional authorities. To gain a deeper understanding of multi-hazard impact chains, PARATUS will first conduct forensic analysis on historical disaster events, augment historical disaster databases with hazard interactions and sectorial impacts, and exploit remote sensing data with artificial intelligence methods. Building on these insights, PARATUS will then develop new exposure and vulnerability analysis methods that enable systemic risk assessment across sectors (e.g. humanitarian, transportation, communication) and geographic settings (e.g. islands, mountains, megacities). These methods will be used to analyse risk changes across space and time and to develop new scenarios and risk mitigation options together with stakeholders, using innovative serious games and social simulations. The results will be hosted on two stakeholder hubs related to crisis management and humanitarian relief, and provide stakeholders with a range of tools for risk reduction planning in dynamic multi-hazard environments. The service-oriented approach with active stakeholder involvement will maximise uptake and impact of the project, and help to increase Europe’s resilience to compounding disasters.

Keywords: co development of scenarios,multi hazard impact chains,systemic risk,compounding disasters,dynamic analysis,artificial intelligence,stakeholder hubs