Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Identification of host-factors restricting Salmonella Typhi (KILLINGTYPHI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Typhoid fever is a life-threatening systemic infection that continues to be a serious global health concern, claiming the lives of over 200,000 patients every year. It is caused by the intracellular bacterium Salmonella Typhi, a human-adapted pathogen unable to infect species others than humans. The molecular mechanisms underlying S. Typhi infection are only partially understood. Spanò and Galán recently discovered an antimicrobial pathway that is required to restrict the growth of S. Typhi macrophages derived from mouse (a non-susceptible host) and contributes to S. Typhi host-restriction. Despite this finding, the exact mechanisms used by macrophages to kill S. Typhi as well as the role of these mechanisms in the adaptation to the human host remain unknown. Through this project, I will investigate the mechanisms used by non-permissive hosts to eliminate S. Typhi. I will combine my strong background in molecular microbiology with the world-renowned expertise of S. Typhi-host interactions of the receiving group to identify host genes required to kill S. Typhi. I will apply state-of-the-art technologies, including pooled shRNA screens coupled to next-generation sequencing and the novel and powerful CRISPR/Cas9 technology, supported by a network of local and international collaborators. Specifically, I will: 1) identify Rab GTPases required for S. Typhi killing, 2) identify novel factors involved in pathogen killing through an unbiased genome-wide screen, and 3) elucidate the role of well-characterized antimicrobial factors in the Rab32-dependent killing of S. Typhi. The results will reveal new strategies of host-defence and will extend our knowledge of the host immunity mechanisms controlling the growth of intracellular pathogens. They have the potential to identify new therapeutic approaches to treat typhoid fever.

Keywords: salmonella typhi,typhoid fever,macrophages,host defence,shrna,crispr,cas9
Life Science Alliance: Closing Research and Innovation Divide in the EU (Alliance4Life)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Health care provision and integrated care
Action type: Coordination and support actions
Countries involved: Estonia,Croatia,Hungary,Lithuania,Poland,Slovenia,Slovakia,Latvia,Czechia
Call: Actions to bridge the divide in European health research and innovation (H2020-SC1-2017-Single-Stage-RTD, 2017)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 944652.5
EU funding (EUR): 944652.5
Participants: 10
Project status: CLOSED

The aim of the project is to establish a European Alliance of ten progressive research institutions from nine less performing countries that are committed to work jointly towards closing the EU divide in health R&I. The Alliance represents a remedial action, which builds on outcomes of the previously performed initiatives analyzing health R&I barriers and enabling factors as proposed by e.g. DanuBalt and RegHealth-RI projects. Alliance4Life consortium will concentrate efforts on both (1) mutual learning and sharing practical experience, and (2) receiving motivating feedback from high performing research institutions. We will establish Focus Groups, open platforms for idea generation and exchange of knowledge, working within eight domains of expertise: science evaluation, HR and recruitment, research funding, core facilities and big data, technology transfer, bio-ethics, science communication, and mobility. In all the domains of expertise, the formation of Alliance4Life enables experience-driven approach focused on best practice cases realized by its members, avoiding actions that failed in the past and promoting those that demonstrated high impact at reasonable cost. The learning process will contribute to institutional reforms in research management and support increased participation in international consortia. The Alliance will develop progressive strategies including suggestions for exploitation of the potential provided by synergies between ESIF and H2020, which will be coordinated with the health R&I managing authorities of the particular less performing countries. The local stakeholders will be motivated to take up proposed strategies through series of national roundtables on institutional and research policy reforms. Spill-over effects will be further fueled by development of training modules and large-scale dissemination of project results.

Keywords: health randi,less performing countries,bridging the divide,esif,h2020 synergies,institutional reform,research policy,randi gap,structural barriers and enablers,research management
Ioculator seu mimus. Performing Music and Poetry in medieval Iberia (MiMus)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Spain
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-09-01
End date: 2024-08-31
Duration (months): 72.0
Total project cost (EUR): 1341869.0
EU funding (EUR): 1341869.0
Participants: 1
Project status: SIGNED

What was the role played by courtly musicians and poets in fostering a performative dimension of cultural life in the late Middle Ages? How did this contribute to the social value of the poet and musician as an artist? In the late medieval period the Crown of Aragon was a political and cultural crossroads, a coveted destination for artists of various kinds who attended the refined court of the Catalan kings. Musicians and performing entertainers with skills in the verbal and non-verbal domains were among the most sought after. This project will review and expand the corpus of documentary evidence informing us about musical activity and performing artists at the court of Aragon in the late medieval period, with the aim to analyse what this tells us about similar activity at other European courts. Thus, it will examine the professional profiles, cultural backgrounds and networks of patronage behind the minstrels who thrived in the Catalan court between 1235 and 1435. The main source of information will be the Archive of the Crown of Aragon in Barcelona and the Archive of Valencia. The project will also consider the debt of Catalan poetry to foreign musicians, with the aim to establish whether any intertextuality exists between Catalan poetry and the poetry produced in the regions adjacent to the territories of the Crown of Aragon that was specifically mediated by the presence of foreign musicians at the Catalan court. Specific objectives of the project will be: 1) to establish whether the ideas of minstrelsy passed down to us by literature and scholarship fit the real profiles of minstrels provided by medieval documents; 2) to evaluate the impact, where appropriate, of contacts between religious and ethnic communities in the profession of minstrelsy in late medieval Iberia; 3) to assess the role of queenship in musical and poetic patronage; 4) to clarify the influence of foreign musical traditions on Catalan poetry.

Keywords: medieval catalan poetry,crown of aragon,cross cultural contacts,queenship studies,medieval system of genres,intertextuality,medieval iberia
Coherent ultraFast Long Wave infrared communications (cFLOW)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Austria,Sweden,Switzerland,France,France
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2018)
Start date: 2019-04-01
End date: 2023-09-30
Duration (months): 54.0
Total project cost (EUR): 3061846.25
EU funding (EUR): 2998096.25
Participants: 9
Project status: SIGNED

A vast potential for high-end photonics application remains untapped in the Long Wave InfraRed region of the electromagnetic spectrum (LWIR, 8-12μm). In particular, Free Space Optical (FSO) communications using LWIR wavelengths could present unmatched availability and speed compared to telecom and RF links, due to extremely low sensitivity to atmospheric perturbation. The cFLOW project will bring photonic integrated circuits concepts to Quantum Cascade Lasers and Detectors (QCL & QCD) technology in order to establish a scientific and technological landmark for LWIR FSO. We will demonstrate a coherent transmission with datarate in the 20-100Gbps range, based on devices operating at room-temperature: (i) a “telecom ready” LWIR QCL chip with record modulation speed (>20GHz), 100% modulation depth, tens to hundreds of mW output power and low RF power consumption. (ii) A high-speed (>20GHz) heterodyne sensor with a sensitivities three orders of magnitude higher than current solutions. The success of the cFLOW project will completely redefine potential architectures for the wireless communications networks of the 21st century.

Keywords: quantum cascade lasers and detectors,mid infrared
Biocatalytic Methyltransferase Cascades (MetTraC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Switzerland
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-03-01
End date: 2020-08-31
Duration (months): 18.0
Total project cost (EUR): 149760.0
EU funding (EUR): 149760.0
Participants: 1
Project status: CLOSED

The goal of this project is to develop a general system for preparative enzyme-catalyzed methylation reactions. Selective methylation of complex molecules can be challenging for synthetic chemistry. Given the exquisite chemo-, regio- and stereoselectivities of enzyme catalysis we believe that biocatalysis presents a powerful alternative for commercial production of pharmaceuticals and fine chemicals. In this project we demonstrate the applicability and commercial viability of a novel enzyme-based technology to preparative methylation reactions.

Keywords: biocatalysis,enzyme catalysis,sulfur,carbon bond formation
INnovation and excellence in massive-scale COMmunications and information processING (INCOMING)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Sweden,Serbia,Denmark
Call: Twinning (H2020-WIDESPREAD-2018-03, 2018)
Start date: 2020-01-01
End date: 2023-09-30
Duration (months): 45.0
Total project cost (EUR): 797810.0
EU funding (EUR): 797810.0
Participants: 4
Project status: SIGNED

Massive-scale data acquisition and information processing for large infrastructures, such as smart grids, smart transportation or smart industry, underpins the emerging fourth industrial revolution. 5G mobile networks and mobile edge computing (MEC) will provide communication and computation platform for such intelligent infrastructures to become a reality. Recognizing the need for expertise and leadership in this domain, with onward looking goal to support rapidly growing regional ICT sector, Faculty of Technical Sciences of the University of Novi Sad (Serbia) established the Centre for intelligent COmmunications, Networking and Information proCessing (ICONIC). ICONIC collects strong research team with a vision to become regional hotspot for 5G research and innovation, focusing on massive Machine-Type Communications, Large-Scale Distributed Information Processing, and Reconfigurable Hardware Design. INCOMING project (Innovation and excellence in massive-scale COMunications and information processING) lays out ambitious research-intensive and innovation-oriented plan to make the ICONIC centre regional 5G lighthouse by twinning it with Aalborg University (Denmark), Chalmers University of Technology (Sweden) and German Aerospace Centre (Germany). INCOMING will use staff exchanges, expert trainings, summer schools and workshops to boost the research excellence of ICONIC staff members focusing on ESRs. The twinning program will gradually shift focus from research to innovation-driven implementation of the promising research outcomes. As part of the project, ICONIC will set up 5G Innovation and Technology Hub (5G-IT-Hub) as an interface towards the regional ICT sector, bridging high-quality ICONIC research with thriving regional ICT innovation scene. With the help of EU partners, INCOMING will put the ICONIC centre on the European map of emerging research-intensive 5G centres, while via 5G-IT-Hub, ICONIC will become integral part of regional ICT innovation activites.

Keywords: machine type communications,mobile edge computing,distributed information,processing,machine learning,reconfigurable hardware,software defined radio,field,programmable gate arrays
Towards a common Una Europa RESearch and INnovation ecosystem (Una.Resin)

Framework: Horizon 2020 — Science with and for Society
Action type: Coordination and support actions
Countries involved: Germany,Spain,Italy,Belgium,Finland,Poland,France,United Kingdom
Call: Support for the Research and Innovation Dimension of European Universities (Part I) (H2020-IBA-SwafS-Support-1-2020, 2020)
Start date: 2021-02-01
End date: 2024-01-31
Duration (months): 36.0
Total project cost (EUR): 1999763.83
EU funding (EUR): 1999763.83
Participants: 8
Project status: SIGNED

Una Europa’s ambition is to create a truly European inter-university environment for collaboration in education, research and innovation. We commit ourselves to driving European leadership by creating a University of the Future as an international, value-driven, innovative community of researchers, students and professional services that is open and inclusive. Through the 1Europe ‘European Universities’ pilot project, we are taking the first steps towards creating a single education eco-system for our students, through establishing a Europe-wide living lab for testing Joint Innovative Formats for education and mobility. In Una.Resin, we will take the first steps towards creating a common research and innovation (R&I) eco-system for our researchers and partners. We will create a university of the future, where our students, researchers and staff, in collaboration with our shared partners and communities, will make the world a better place. In Una.Resin we will create shared strategies on Research and Innovation, Sharing Research Infrastructure and Resources, and Strengthening Human Capital. For each of these strategies, we will develop accompanying action plans and roadmaps and - through a series of pilot actions - begin their implementation. We will test innovative models for barrier free interdisciplinary cross-border collaboration and team science to address societal challenges. We will develop and test new ways of sharing our existing digital research infrastructures with a wider group of academic, non-academic, and citizen stakeholders. We will identify and test solutions to overcome any current barriers that may hinder the establishment of a seamless, common R&I eco-system. Throughout our joint action plans, we will incorporate specific elements to ensure the mainstreaming of Open Science, and to fully embed both citizens and other non-academic actors in all stages of the R&I lifecycle.We become a global model for international research collaboration.

Keywords: european university,transformation,infrastructure,human capital,citizen science,collaboration,interdisciplinary,onehealth,cultural heritage,european studies,data science,sustainability
Innovative designs to enable plastic packaging circular economy (NATURE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Industrial Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain,Spain,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 1093606.44
EU funding (EUR): 1093606.44
Participants: 4
Project status: SIGNED

Plastics are the material of choice in packaging applications because of their low cost, high performance and ready processability. Such is their success that it is expected that by 2050 the production of plastic packaging will exceed 250 million metric tons. Considering most plastics that are employed in the packaging industry are used for less than a week, the lack of environmental degradability has led to a tremendous growth of disposed plastics. This growth, together with the fact that the vast majority of synthetic plastics are designed for performance and durability and not for degradability and recyclability, has brought tons of plastic accumulation in the oceans and landfills - ~56 million tons per year. The problem has been highlighted by the acclaimed prediction that by 2050, the ocean is expected to contain more plastics than fish (by weight). Although it was envisioned that biodegradable polymers based on ester linkages such as poly(lactide) (PLA) or poly(3-hydroxybutyrate) could be part of the solution because they are mainly derived from biorenewable sources (e.g. starch and cellulose) and can be enzymatically or hydrolytically degraded leading to an environmentally closed circular ecosystem, the low permeability in the case of PLLA and the poor mechanical properties in the case of PHB has limited their potential. NATURE-EID proposes an innovative research training program at the forefront of circular economy of biobased polyesters. In particular, the project will develop fundamental knowledge in the synthesis of new biobased polymeric materials where the polymers are not only design based on their performance but also on their recyclability.

Keywords: biobased polyesters,polymeric materials,recyclability,sustainable polymerization processes
Choosing Islamic Conservatism: Muslim Youth in Europe and the UK and the Question of Social Cohesion (CICMSC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: United Kingdom
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 2455847.0
EU funding (EUR): 2455847.0
Participants: 1
Project status: SIGNED

The Islamic networks that historically embedded themselves in Muslim communities within Europe and the UK represent, in theological and methodological terms, most conservative Islamic knowledge traditions, which promote highly conservative social norms, encourage isolation from mainstream society, and in extreme cases also endorse jihad. Despite facing serious competition in recent years from Islamic scholars and institutions that are actively trying to promote teachings from the classical Islamic scholarly tradition, which balances textual loyalty with a focus on contemporary social reality, thereby providing more socially optimal outcomes for young Muslims in the West, the conservative Islamic movements still control the mosque and madrasa (Islamic school) networks and have a visible constituency among second- and third- generation Muslims in the West. Working within theories of institutional persistence and change, and complementing them with a focus on understanding the significance of ethical and moral agency as discussed in recent studies in anthropology of Islam, and taking cues from the growing interest in the role of neighbourhoods in religious socialisation, this project develops a conceptually and methodologically unique approach to understand the stickiness of Islamic conservatism in the West. It has a three-fold focus: (1) studying the survival strategies of the institutional elites, as well as any attempts at internal reform; (2) expanding the existing focus on push factors (childhood socialisation and reactionary religiosity) to also study the pull factors (such as the possible appeal of the ethical and moral agency that these movements are able to inculcate); and (3) testing the hypothesis that ‘mosque-dense Muslim-majority neighbourhoods’ are central to engraining a conservative social Islamic imaginary in each subsequent generation, which through a dense network of bridging ties is spread to Muslim youth across the country.

Keywords: conservative islamic movements,muslim communities in europe,social cohesion,muslim youth,institutional persistence and change