Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
AN INTEGRATED AUTOMATED ECG DIAGNOSTICS PLATFORM TO IMPROVE CARDIAC SAFETY IN CLINICAL DRUG TRIALS (CASI)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Ireland
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-03-01
End date: 2015-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Vitalograph is a 50 year old company, that designs, manufactures and sells medical devices in clinical settings and clinical drug trials. This proposal focusses on the validation of a new dual-purpose 12 lead ECG diagnostics device incorporating an automated algorithm to be used in the regulatory mandated cardiac safety elements of clinical drug trials. Current solutions are expensive, introduce unnecessary analysis delays and have poor data consistency. The proposed solution can cut customer costs by 50% whilst at the same time improving Vitalograph’s margin from 25% to 70% as well as reducing the analysis time from several days to a few minutes. The target market has grown to be greater than €1.6Bn in 10 years with the targeted segment being one third of this. The target customers are pharmaceutical companies conducting drug trials The project fits well with Vitalograph’s product and market strategy to develop new medical devices for clinical drug trials and will increase the available market by a factor of 10. The company already operates successfully within the market having participated in over 50 trials totalling €56m in revenue since entering the market ten years ago. It has the R&D skills and bandwidth, operational capacity and commercial capability to fully exploit the resultant offering. Vitalograph has already established a market in cardiac safety in clinical trials by buying in other devices and services. Vitalograph will work with the world-renowned Glasgow University ECG group as a 3rd party to validate their existing clinical algorithms for automated use in clinical drug trials. An IP licensing agreement is already in place and no IP issues are anticipated. The market is heavily regulated under medical device legislation in all jurisdictions (CE MDD, FDA, CSA, JPAL, CFDA etc.) but Vitalograph already has the necessary approvals, experience, regulatory knowledge and certifications to bring this product to the market.

Keywords: cardiac safety
High-resolution Imaging with Phase Retrieved Tomography (HI-PHRET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-03-01
End date: 2021-02-28
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

Optical tomography is a modern field of indisputable interest that fosters advances in the study of biological processes. Even if this scientific pairing seems to proceed tightly bind, sometimes current methodologies vacillate to satisfy imaging requests coming from the medical world. In this scenario, the intention of High-resolution Imaging with Phase Retrieved Tomography (HI-PHRET) project, is to achieve the maximum tomographic resolution taking advantage of cutting-edge photonics and computational techniques. In fact, Phase Retrieval (PR) methods are unveiling their promising imaging capabilities since, with the current technology, we are able to measure a “mere” amplitude-only image. The recovery of phase information opens up numerous possibilities, drafting the goal of the project: put PR algorithms at the service of the biomedical imaging world. Mechanical misalignment, scattering and hidden imaging can be efficiently handled with PR implementations, further advancing towards the highest tomographic resolution. HI-PHRET will thrive at Politecnico di Milano, under the supervision of Prof. Pifferi, and will project me into the excellences of the European scientific panorama. Thanks to the possibilities offered by the prestigious MSCA-IF and by the inclusion in a well-structured multi-disciplinary network, I will be able to grow professionally maturing further independent-thinking and project-management skills. The interaction with universities, research institutes, industries and companies (also by means of two secondments), as well as direct contact with technology-transfer offices, will open up new possibilities for my career and maximise the impact of the research action. Dissemination, exploitation and communication strategies planned throughout the project will encourage me to think different, trying to catch the attentions of the broadest audience but focusing on concrete problematics, always keeping an eye on potential technology transfer.

Keywords: phase retrieval,optical tomography,biomedical imaging,fluorescence imaging,image reconstruction
Construct and Collapse: Self-emergence and dynamics under global-change scenarios of mutualistic systems (CoCo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

To move ecology towards a more predictive body of theory to anticipate how biodiversity and ecosystem functioning may respond to anthropogenic perturbations, particularly global change, is a foremost challenge for evolutionary and community ecologists in the upcoming years, and a high-priority goal in EU policy. The proposed project “CoCo – Construct and Collapse: self-emergence and dynamics of mutualistic systems under global change scenarios” aims at creating a multidisciplinary and integrative approach which will provide us with a unique opportunity to study relevant aspects of ecological communities which are not well understood. Using an enormous amount of high-resolution data from different ecological disciplines and at a macroecological scale, and complementary state-of-the-art modeling tools, we will create a predictive model able to reproduce the structure of ecological networks. Although highly complex and diverse, the structure of ecological networks can be replicated with simple rules describing evolutionary and ecological mechanisms. This model will then be used, together with the latest climate change projections, to monitor network response to global change perturbations under a number of climate change scenarios. Specifically, we will monitor precisely how individual species react to these perturbations, and explore potential compensatory mechanisms, cascading effects and network breakdown patterns. By exploring these responses, we will be able to identify which network structures and species network roles render a higher resilience to climatic perturbations, and refine the network keystone species concept. We will also be able to find areas and species of higher conservation priority and identify early signs of disruption in other networks. CoCo will create new analytical opportunities, and overcome past methodological weaknesses, situating our findings and methodology in the forefront of the field of ecology.

Keywords: ecological networks,spatial distribution models,agent based modeling,optimal foraging theory,hummingbird plant interactions,climate change,conservation,species response to global change
Compound-Specific Radiocarbon Analysis to Date Prehistoric Human Cultural Change (LIPDAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-08-01
End date: 2020-01-31
Duration (months): 18.0
Total project cost (EUR): 149940.0
EU funding (EUR): 149940.0
Participants: 1
Project status: CLOSED

Pottery typology is the principal method used to date archaeological sites, however, the approach provides relative rather than absolute dates. Paradoxically, 14C dating using accelerator mass spectrometry (AMS) is the technique used to assign absolute or calendrical dates, but pots, being fabricated from fired clay, i.e. aluminosilicate, lack endogenous organic carbon and so cannot be 14C dated directly. Carbonaceous tempers, amorphous residues adhering to the surface and carbon-based materials co-occurring in the same archaeological deposits as pots have all been 14C-dated but problems exist with either the frequency of occurrence and/or uncertainties of their association(s) with pottery and contamination of these remains. To enable the routine 14C dating of pottery the PI initiated development of a new approach that uses commonly occurring fatty acid components of lipid residues derived from food processing, adsorbed within the protected environment of the walls of vessels. As part of the NeoMilk ERC Advanced grant a new protocol been developed for the extraction and isolation of these compounds using preparative capillary gas chromatography in high purity and sufficient amounts for high precision 14C dating by AMS. This new approach offers a step-change in archaeological dating, which will attract international demand to date archaeological sites. Our aim now is to bring this new method of pottery dating into routine use in archaeology worldwide. This project will take the first steps towards achieving this ambition. This Proof of Concept grant will allow us to (i) develop a commercialisation plan, (ii) demonstrate the utility of the approach temporally and spatially, (iii) analyse the global market, (iv) formulate and deliver an IPR strategy, and (v) promote the method to academic and commercial networks.

Keywords: high precision radiocarbon dating,archaeology,pottery,fatty acids,academic and,commercial,cultural heritage
Neurophysiological Biomarkers of Cortical Plasticity Induced by Neuromodulation (NeuroN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-23
Duration (months): 23.0
Total project cost (EUR): 159461.38
EU funding (EUR): 159460.8
Participants: 2
Project status: CLOSED

One of the major issues when dealing with therapies for the rehabilitation of the lower limbs in stroke survivors is the in-deep assessment of their effectiveness and the lack of biomarkers for motor recovery. The motor functionality after therapy is evaluated only through clinical tests and scales which do not give information on the effective muscle state and the changes at the corticospinal level. The aim of restoring the motor functions has moved much of the attention of clinicians and researcher towards the use of the combination of brain stimulation techniques for the assessment of cortical excitability and Brain-Computer Interfaces (BCI) for the control of rehabilitation devices. This intervention induces cortical plasticity and reactivates the closed-loop pathway between the impaired cortical tract and the limb by using the cortical command to drive the device for the generation of the afferent volley. However, nothing is known about the changes of the neurophysiological correlates and how these influence the effective recovery of motor functions. NeuroN represents the first systematic attempt to investigate the neurophysiological correlates of changes in the excitability of the cortical areas responsible for ankle dorsiflexion in chronic hemiparetic stroke survivors with drop foot impairment and to identify novel biomarkers of motor recovery. NeuroN aims at filling the gap of knowledge on the functional effects of increased plasticity in chronic stroke survivors by integrating a BCI robot-based platform with the high-density surface electromyographic (HD-sEMG) recordings. The information coming from the decomposition of HD-sEMG signals give insight into the behavior of the motoneurons in the spinal cord and on the effective control command. NeuroN is expected to address one of the most intriguing issues in the neurorehabilitation field: the novel biomarkers developed will help in shaping new therapies for the recovery of motor function of stroke patients.

Keywords: cortical plasticity,brain computer interface,high density electromyography,motor neurons
Ethics and Ageing (Ethics and Ageing)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Population aging will raise formidable ethical challenges for the European Union in the coming decades. Declining fertility rates and increased longevity are gradually increasing the ‘dependency ratio’ – the ratio of persons aged over 65, to persons of working age. In 2010, the EU-wide dependency ratio stood at 26%; by 2050, it will rise to 50% (Eurostat projections). As the balance in numbers shifts from citizens who work to those who are retired, the question of how to sustain the key programmes of the welfare state becomes ever more pressing. How can EU public policymakers best maintain their commitment to social solidarity under conditions of population ageing? This research project proposes a comprehensive analysis of the ethical challenge posed by population aging. It is based on the following guiding observation: while European Union policy-makers (especially in the European Commission) are conscious of the fact that the EU needs an overall strategic approach to this challenge, they do not have at their disposal scholarship that provides an ethical analysis of this challenge at the appropriate level of generality. The project will be based in the Department of Philosophy of Law at Universitat Pompeu Fabra (UPF). It will be supervised by Professor Andrew Williams, one of the world’s leading political philosophers, under the auspices of the UPF research group, the “Philosophy of Law”. Additionally, the project will be developed in dialogue with one of the world’s leading social scientists on the welfare state and population aging, Professor Gøsta Esping-Andersen, who runs the “DEMOSOC” research group at UPF. The project will thus have an interdisciplinary character, moving back and forth between ethics and social science, and more specifically, between these two research groups at UPF, with the aim of producing comprehensive and grounded guidance on a key challenge facing the European Union.

Keywords: ageing,social justice,liberal equality
DE-ENIGMA: Multi-Modal Human-Robot Interaction for Teaching and Expanding Social Imagination in Autistic Children (DE-ENIGMA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Serbia,Belgium,Romania,Netherlands,United Kingdom,United Kingdom,Portugal
Call: Technologies for better human learning and teaching (H2020-ICT-2015, 2015)
Start date: 2016-02-01
End date: 2019-11-30
Duration (months): 46.0
Total project cost (EUR): 3904188.0
EU funding (EUR): 3904187.75
Participants: 9
Project status: CLOSED

Autism Spectrum Conditions (ASC, frequently defined as ASD - Autism Spectrum Disorders) are neurodevelopmental conditions, characterized by social communication difficulties and restricted and repetitive behaviour patterns. There are over 5 million people with autism in Europe – around 1 in every 100 people, affecting lives of over 20 million people each day. Alongside their difficulties, individuals with ASC tend to have intact and sometimes superior abilities to comprehend and manipulate closed, rule-based, predictable systems, such as robot-based technology. Over the last couple of years, this has led to several attempts to teach emotion recognition and expression to individuals with ASC, using humanoid robots. This has been shown to be very effective as an integral part of the psychoeducational therapy for children with ASC. The main reason for this is that humanoid robots are perceived by children with autism as being more predictable, less complicated, less threatening, and more comfortable to communicate with than humans, with all their complex and frightening subtleties and nuances. The proposed project aims to create and evaluate the effectiveness of such a robot-based technology, directed for children with ASC. This technology will enable to realise robust, context-sensitive (such as user- and culture-specific), multimodal (including facial, bodily, vocal and verbal cues) and naturalistic human-robot interaction (HRI) aimed at enhancing the social imagination skills of children with autism. The proposed will include the design of effective and user-adaptable robot behaviours for the target user group, leading to more personalised and effective therapies than previously realised. Carers will be offered their own supportive environment, including professional information, reports of child’s progress and use of the system and forums for parents and therapists.
Pianosilica – new, eco-friendly and fire-resistant construction materials. (PIANOSILICA)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Poland
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2015, 2015)
Start date: 2016-04-01
End date: 2016-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The main objective of the Project is to develop the best method and parameters of manufacturing Pianosilica on industrial scale as well as to determine the best path to widely implement the technology and enter the whole European, and finally global market. Pianosilica are novel, ecological, fire-resistant materials based on patented technology. They can be applied to building industry, insulation materials, construction chemicals and sealing materials. Features that distinguish this solution include a simple manufacturing method and the possibility to use widely available inorganic substrates - including waste. Foaming is carried out in moulds at a temperature lower than 500°C, by means of microwave radiation or electric current. The foamglass received as a result of the innovative method of foaming, depending on the type of filler, preserves its qualities up to 1300°C. Additionally, it is characterized by the resistance to water vapor penetration and, contrary to products based on mineral wool, it has the qualities of a construction material. The primary benefit for our customers will be reducing energy costs. The implementation of an innovative and validated technology will provide a new generation of construction materials to be used globally, which will be cheaper, environmental friendly, more energy efficient and safer. That will be additional catalyst to increasing market share, what is one of the goals of the European Commission in terms of creating a competitive, environmentally friendly and low-carbon economy. Feasibility study will enable us to verify the feasibility and viability of launching Pianosilica on international market. PHASE I is only the beginning and we believe it will lead to PHASE II. This will enable us to identify resources needed for commercial implementation of our technology.

Keywords: fire resistancy,non organic materials,high temperature insulation
INtegrated TOol chain for model-based design of CPSs (INTO-CPS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: A new generation of components and systems: Engineering of advanced embedded and energy and resource efficient components and systems
Action type: Research and Innovation actions
Countries involved: Ireland,Germany,Germany,Sweden,France,France,Netherlands,United Kingdom,United Kingdom,Denmark,Denmark
Call: Smart Cyber-Physical Systems (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 7956805.25
EU funding (EUR): 7956804.25
Participants: 13
Project status: CLOSED

The aim of the INTO-CPS project is to create an integrated tool chain for comprehensive model-based design of Cyber-Physical Systems (CPSs). The tool chain will support the multidisciplinary, collaborative modelling of CPSs from requirements, through design, down to realisation in hardware and software. This will enable traceability at all stages of the development. INTO-CPS will support the holistic modelling of CPSs, allowing system models to be built and analysed that would otherwise not be possible using standalone tools. We will integrate existing industry-strength tools with high Technology Readiness Levels (TRL 6–9) in their application domains. The solution will be based centrally around Functional Mockup Interface (FMI)-compatible co-simulation. The project focuses on the pragmatic integration of these tools, making extensions in areas where a need has been recognised. The tool chain will be underpinned by a well-founded semantic foundations that ensures the results of analysis can be trusted. The tool chain will provide powerful analysis techniques for CPSs, including connection to SysML; generation and static checking of FMI interfaces; model checking; Hardware-in-the-Loop (HiL) and Software-in-the-Loop (SiL) simulation, supported by code generation. The tool chain will allow for both Test Automation (TA) and Design Space Exploration (DSE) of CPSs. The INTO-CPS technologies will be accompanied by a comprehensive set of method guidelines that describe how to adopt the INTO-CPS approach, lowering entry barriers for CPS development. The tool chain will be tested with case studies in railways, agriculture, building and automotive. The consortium has 4 academic and 7 industrial partners. The industrial partners comprise both tool vendors and case study owners. The INTO-CPS technology will enable experimenting with design alternatives enabling radical innovation where the overall concept is right first time, even when hardware prototypes does not yet exists.

Keywords: model based design,collaborative modelling and simulation,well founded toolchain,model checking,design space exploration,test automation,sysml,embedded systems,semantics