Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Smart, Multifunctional Dental Implants: A Solution for Peri-Implantitis and Bone Loss (I-SMarD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Research and Innovation actions
Countries involved: Italy,Greece,Switzerland,United Kingdom,United Kingdom,United Kingdom
Call: Biological scaffolds for tissue regeneration and repair (RIA) (H2020-NMBP-TR-IND-2020-twostage, 2020)
Start date: 2021-04-01
End date: 2025-03-31
Duration (months): 48.0
Total project cost (EUR): 5099851.25
EU funding (EUR): 5099851.25
Participants: 6
Project status: SIGNED

At the moment, peri-implantitis remains an unsolved issue not only within EU but also worldwide, affecting up to 43% of the dental implants, with heavy smokers, patients with systemic health conditions (e.g. uncontrolled diabetes) and the immunosuppressed to be more vulnerable to the disease. Currently used dental implants are of low functionality and prone to bacterial colonisation and to the formation of bacterial biofilm. I-SMarD aims to provide a proactive option for solving the outstanding condition, by delivering multifunctional dental implants which; i) can detect the changes of the surrounding microenvironment and respond by releasing agents (e.g. nanoparticles, antibiotics) to prevent bacterial colonisation; ii) will have the appropriate structure to match the anatomical characteristics of dental tissues and the components to promote the formation of implant/bone and implant/soft tissue interfaces; iii) will be coated with photoactive layers which will enable the non-invasive monitoring of the healing process (i.e. health of soft tissue) after surgery. With these we aim to prevent bacterial colonisation around dental implants and reduce the required time and cost of rehabilitation period for patients benefit. The addition of photo-active layers will impact on the diagnosis of peri-implantitis offering clinicians a diagnostic tool on live monitoring of tissue healing. For the fabrication, we will utilise advanced manufacturing techniques as 3D printing of titanium (Ti) and Ti alloy powders and Pulsed Laser Deposition for coating the surface of the implants. This will allow the delivery of complex, functional but at the same time low cost, personalised implants. Aim of our multidisciplinary team is not only the development of an advanced implant but also the delivery of a promising, low cost product that will benefit the manufacturing and nanotechnology sector.

Keywords: dental implants,ph regulated drug delivery,photoactive coating,healing monitoring,personalised implants,3d printing,peri implantitis
Modelling and Computation of Shocks and Interfaces (ModCompShock)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Germany,Spain,Italy,Italy,Norway,Greece,France,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-10-01
End date: 2020-12-31
Duration (months): 63.0
Total project cost (EUR): 3914276.31
EU funding (EUR): 3914276.31
Participants: 9
Project status: CLOSED

The proposed ITN entitled "Modelling and computation of Shocks and Interfaces" will focus on the training of young researchers in the general area of nonlinear hyperbolic and convection dominated PDEs with emphasis on innovative modelling and computational methods. The research program of the proposed ITN is centered on an important field (in terms of both history and scope), that is placed at the forefront of modern Computational and Applied Mathematics. The fact that hyperbolic convection dominated PDEs is probably one of the very few areas within Computational and Applied Mathematics, where traditionally modelling, Physics, Mechanics, analytical approaches, and advanced computational methods have contributed in synergy to several achievements to date, makes this field eminently suitable to train young researchers in. These researchers can become research leaders in a wide area as well as impacting on both industry and non-academic scientific institutions. The network will consist of some of Europe's leading research groups on hyperbolic PDEs, and includes experts on Modelling, Analysis and Computation. A well defined training program is outlined in the proposal. The training program emphasises the European and international dimension of the effort. The training design is expected to produce effective results and foster the expertise on how to structure doctoral training at the European level and enhance the innovation capacity of the involved individuals. The innovative techniques developed will be applied to diverse concrete problems ranging from fluid dynamics and geophysical flows to materials science. In the pursuance of this goal, the research groups will be assisted by experts in these areas of application and non-academic partners, resulting in a significant enhancement of the impact of the research and training program

Keywords: numerical methods for pdes,hyperbolic systems,convection dominated pdes,uncertainty quantification,propagating interfaces,euler equations,adaptivity
Innovative push-pull wheelchair accessory to provide mobility, rehabilitation and leisure activities for much more disabled people than today (STRINGHANDBIKE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Hungary
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-07-01
End date: 2022-10-31
Duration (months): 40.0
Total project cost (EUR): 1618312.5
EU funding (EUR): 1132818.75
Participants: 1
Project status: SIGNED

Stringbike Ltd. is presenting a truly innovative, patented wheelchair attachment, which will revolutionise the user experience, and the life quality of millions disabled people. Our solution combines mobility with therapeutic qualities, and fun! The concept is based on 4 pillars: Innovative Technology, Social Sensitivity, a Business Opportunity, and a TEAM to deliver. On the basis of our strong international patent portfolio, we developed a string driven accessory attached to manual wheelchairs. The product, Stringhandbike, offers significantly improved therapeutic and recreational opportunity for disabled people. In Europe ~1,5 million people use manual wheelchairs. The worldwide potential for us is €50M/year. There are numerous solutions, but none can compete with Stringhandbike’s maneuverability, ease of use, comfort, adjustability and therapeutic opportunities, as validated with 150 wheelchair users. The market opportunity of Stringhandbike is proven by receiving clear preference over other solutions. Users are willing to pay about one month’s income for Stringhandbike, thus the planned €1700 retail price is very competitive. Our commercialization plan is based on a direct, demonstrative selling approach, requiring a direct sales force through local disabled communities of target countries. Our team has the key skillset: leadership, disabled community, finance, distribution, technology, manufacturing, and a diverse ownership structure, including management. We have strong financial commitment from our owners, securing the necessary co-financing for our Phase-2 proposal. Since the Seal of Excellence Certificate in 2017, we sold our first test units in Hungary, UK, Denmark and Australia, verified the corporate sponsorship model, tested with Budapest Public Bikesharing System. We launched the Austrian market survey in close cooperation with ÖZIV, the leading disabled organization and we have found our main distribution partner, Maierhofer Gmbh. in Klagenfurt.

Keywords: disability,disabled people,rehabilitation,equality,diversity,spinal cord injury,disabled mobility,wheelchair,transport,therapy,health,quality of life,illness prevention,recreation,leisure
Endocytic logistics of defense signaling in plants (ENDOLOGISTIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: SIGNED

Cells sense extracellular signals via their surface localized transmembrane receptor kinases. Although long regarded as a conduit for cell surface receptor degradation or recycling, the endosomal system is also an essential site for signal transduction. Say endosomes are the logistics platforms for receptors, activated receptors accumulate in endosomes, and certain signaling components are exclusively localized to endosomes. Receptors can continue to transmit signals from endosomes that are different from those that arise from the plasma membrane, resulting in distinct physiological responses. In mammals, endosomal signaling was demonstrated for many receptor families including receptor tyrosine kinases, G‐protein‐coupled receptors and toll‐like receptors. Unlike mammals, the mechanisms of endosomal signaling in plants are unknown. Recent study of the immune receptor PEPR1 that perceives the endogenous peptide Pep1, showed that endocytosis is required for mitogen-activated protein kinase (MAPK) activation after elicitation with Pep1. However, because MAPK activation occurs faster than the endocytosis of the main receptor it raised the question if endocytosis of so far unknown signaling components is required for Pep1-elicited immune responses. In ENDOLOGISTIC, I aim to identify those components. To reach this goal, I will perform proteomics and phosphoproteomics analyses on isolated endosomes after elicitation with Pep1. This will enabled me to map and to correlate endosomal-specific phosphorylation with changes in subcellular protein distribution. Furthermore, I will employ the proximity labelling method to identify components of both the PEPR1 signaling complex and endosomal or autophagy machinery. In ENDOLOGISTIC I will combine my expertise in immunity with state -of- the -art proteomics, live cell imaging and genome-editing techniques available at the host institute to further advance our understanding of how endocytosis controls immunity in plants.

Keywords: arabidopsis,clathrin coated vesicles,endosomal signaling,phosphoproteomics,pepr1 receptor
Uncovering the molecular dialogue between the arbuscular mycorrhizal fungi and the non-host plant. (AraMyco)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 177598.8
EU funding (EUR): 177598.8
Participants: 1
Project status: CLOSED

The arbuscular mycorrhizal (AM) symbiosis is one of the most ancient, abundant, and ecologically important mutualisms on Earth. Yet, despite its crucial role in land ecosystems, molecular mechanisms leading to its formation are just beginning to be unraveled. However, approximately 18% of all land plants, including important crop species, do not form a symbiosis with AM fungi (AMF) and can even be antagonized by them. These non-mycorrhizal plants include several major crops as well as many important weeds. Until now, molecular interactions between AMF and non-host plants have been poorly understood, possibly due to the absence of a suitable model system. Recently, it has been demonstrated that the non-host model plant Arabidopsis thaliana becomes heavily infected by AMF when exposed to mycorrhizal networks that are established by neighboring host plants, resulting in a strong reduction of growth of the non-host plant. However, arbuscules, the most characteristic structure in the AM symbiosis, have not been found in this interaction. These results point to a different interaction between A. thaliana and AMF compared to a functional symbiosis AMF host plant. Here we propose to utilize the well-established Arabidopsis model system to investigate the molecular mechanisms that explain the biological basis of AM fungal incompatibility through a multidisciplinary approach. We will test whether growth suppression previously observed in AMF-infected Arabidopsis is caused by nutrient limitation or by a costly activation of plant defenses. In addition we aim to identify gene regulatory networks that are activated in the three (fully sequenced) partners of the mycorrhizal network Medicago truncatula-Rhizophagus irregularis-Arabidopsis. This will allow us to study in detail key AM fungal genes and molecular processes that are responsible for symbiosis in host plants and for incompatibility in non-host plants, thereby providing novel tools to design new crop protection strategies

Keywords: arbuscular mycorrhizal symbiosis,host interaction,non host intaeraction,plant defense response,biological control
Spiking network mechanisms underlying short term memory (HIRESMEMMANIP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Israel
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-10-01
End date: 2022-09-30
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Short term memory (STM) is impaired at old age and a host of neuropsychiatric disorders, and has been the focus of a multitude of psychological and theoretical studies. However, the underlying neuronal circuit mechanisms remain elusive, mainly due to the lack of experimental tools: we suggest that rapid manipulations at the neuronal level are required for deciphering underlying mechanisms. We have developed an approach combining large-scale extracellular recordings and high density multi-site/multi-color optical stimulation (“diode-probes”), which enables high resolution closed-loop manipulation of multiple circuit elements in intact, free, behaving rodents. After training mice and rats to perform bridging-free STM-tasks, we will evaluate local circuit mechanisms in hippocampus and prefrontal cortex. Two broad classes of manipulations will be used: First, necessary components and timescales needed for STM maintenance will be established by focal real-time silencing of specific cell types and real-time jittering of spiking in those cells. Second, sufficient components (neuronal codes) will be determined by a circuit-training phase, in which novel associations between synthetic brain patterns and behaviorally-relevant short-term memory traces will be established. The first class is equivalent to erasing memories and the second to their writing. Together, these manipulations are expected to reveal global and local circuit mechanisms that facilitate STM maintenance in intact animals

Keywords: optogenetics,precise timing,memory,oscillations,mice,rats,hippocampus,prefrontal cortex,extracellular
Producing transnational nuclear expertise in Italy (1955-1987): a historical-ethnographic approach (NUCLITEX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-08-30
End date: 2021-08-29
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

Focusing on the case of nuclear power in Cold War Italy, this research project analyses the transnsation dynamics of knowledge production involving political elites, official and unofficial scientific experts, the associative milieu, and the public sphere. It covers the period going from the beginning of Italy’s nuclear programme in the early 1950s, to the referendum of 1987 that marked the end of Italy’s nuclear programme. It investigates how Italian experts and counter-experts built their own knowledge(s) through weaving transnational links with other European countries and with the USA; how they navigated forms of public engagement to advance or challenge nuclear power programmes; and how they tried to produce and legitimate, or dismiss, alternative types of knowledge and expertise on the environmental and health risks of nuclear energy in Italy. While it focuses on an existing trend in the science and technology studies, it does so in relation to a EU country – Italy - a historical period – post-1960s - and a form of energy – nuclear - that have not yet been explored by academic studies. By adopting an interdisciplinary approach joining methods and theories from the history of technology and the STS, the project intends to enable academics and analysts to understand more fully the interactions between officials, scientists, and publics in nuclear affairs.

Keywords: nuclear energy,expertise,italy,social movements,history of energy
Structural study on mitochondrial ribosome assembly in human cells (ItohRibo)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-21
End date: 2020-06-20
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

Human mitoribosome represents a distinct class of ribosomes that has specialized in synthesizing exclusively 13 hydrophobic membrane proteins, forming the catalytic core of the respiratory chain. The mature mitoribosome is composed of 82 nuclear encoded proteins and three mt-rRNAs. It is postulated that mitoribosomes are formed in an intricate and well-defined hierarchical process, involving hundreds of proteins and RNA molecules working in cooperation and under tight regulation. However, a structural insight into this process is completely lacking and most of the trans-factors remain unknown. I propose to fill this gap by harnessing CRISPR/Cas9 for genome editing in combination with the state of the art methods in single particle cryo-electron microscopy (cryo-EM). By combining these techniques with biochemical characterization, I will reveal mechanistic insights into how mitoribosomal proteins are assembled in a cascade while nascent mitochondrial rRNA molecules are processed and folded. Since high resolution cryo-EM allows now a unique ability to investigate heterogeneous ribosomal populations and built de novo models, the proposed work will not only reveal the maturation states, but also currently unknown factors implicated in the process. On the other hand, the mitochondrion is compartmentalized into sub-organelle sections such as nucleoids, RNA granules, and membrane-related milieus, and they co-localize with various stages of the mitoribosome assembly. I will also use cryo-electron tomography (cryo-ET) to expand the scope beyond the mitoribosomal complexes and reveal the dynamics of the maturation process and transport mechanism of the assembly intermediates between the sub-organelle compartments. Our approach relies on the most recently developed methodologies and proven strength of the lab complemented by specialized expertise of collaborators, aiming to characterize the transient and low abundant complexes in human mitochondria.

Keywords: ribosome assembly,maturation,mitochondria,translation,cryo electron microscopy,cryo em
paINTed mEtal aRteFActs ConsErvation (INTERFACE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-03
End date: 2020-09-16
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

The use of science for the conservation of cultural heritage is nowadays widespread. Many studies have been conducted on artworks made of single materials (e.g. paintings, stones, metals). However, a novel research field is rising among European conservation scientists: the characterisation and conservation of composite artefacts. This project will be focused on composite artworks made of painted metal. Indeed, the particular use of metals as “canvas” has never been investigated even though many masterpieces were created using this technique. Known are the degradation mechanisms occurring to metal artefacts as well as to paints as single materials. However, rare studies about painted metals and paint-metal interactions have been undertaken so far. Indeed, there is an extended lack of knowledge about the degradation processes that occur on such artefacts and about the conservation methodology to adopt. The project INTERFACE (paINTed mEtal aRteFActs ConsErvation) aims to fill this lack of scientific information, having two main objectives: 1. The characterisation of the degradation mechanisms, with particular attention to the processes occurring at the paint-metal interface; 2. The development of a conservation methodology to preserve both paint film and metal substrate. In particular, the decay mechanisms and the conservation approaches of copper and iron/low carbon steel as substrates decorated with linseed oil paints and lacquers will be investigated. The first phase of the project will focus its attention on the permeation of the paint film, on the metal corrosion processes (e.g. differential aeration, cathodic delamination) and on the interaction between the binder fatty acids and the metal substrate at their interface. For the first time the interface area between the paint film and the metallic support will be characterized at micro and nano-scale. The second phase will be devoted to the development of a conservation methodology for painted metal artworks.