Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
AI Platform foR functionalizing Efficient Cellular solutIonS In Optimizing Novel Drug Treatments (PRECISION-DT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

KSILINK is a European Deep Tech company revolutionizing the development of therapeutics for neurologic and muscular diseases lacking specific treatments. By employing a unique "human efficacy first" approach, we enhance the understanding of human disease biology and mitigate late-stage failure risks through patient-based cellular disease models. Our proprietary AI-driven high content image analysis and data integration skills accelerate phenotypic drug discovery and reduce the development risks for first-in-class therapeutic compounds. Aligned with European academic excellence and open innovation principles, KSILINK collaborates extensively with partners from the quadruple helix to deliver tangible results to the pharmaceutical industry. PRECISION-DT, leveraging KSILINK's advanced drug discovery programs, aims to deliver valuable therapeutic candidates. In partnership with the Lead Discovery Center, we are developing two new chemical entities targeting rare diseases, paving the way for treatments of Muscular Dystrophies and Cardiomyopathies. Additionally, our therapeutic oligonucleotide approach addresses synaptic dysfunctions leading to Phelan McDermid Syndrome as a gateway indication into specific Autism Spectrum Disorder subgroups. This initiative enhances our DeepTech platform, expediting drug target discovery and biotherapeutic development (development from TRL 5/6 towards commercialization). Through PRECISION-DT, we aim to realize the vision of faster precision medicine via patient-based drug discovery, making a lasting impact on patients’ lives, the health sector, and the European economy.

Keywords: drug discovery,autism spectrum disorder,human based disease modelling,ai powered data mining,myotonic dystrophy type 1,dilated cardiomyopathy,phelan mcdermid syndrome
How migration decisions are made: diverse aspirations, trajectories, and policy effects (DYNAMIG)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Germany,Morocco,Kenya,Luxembourg,Netherlands,Italy,Nigeria,United Kingdom
Call: Decision-making processes of (aspiring) migrants (HORIZON-CL2-2022-TRANSFORMATIONS-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2695482.25
EU funding (EUR): 2695482.25
Participants: 8
Project status: SIGNED

The EU and its Member States pursue a wide range of policies that address migration, including development cooperation, border management, and legal labour market access. To be effective, policies must be based on an accurate understanding of how individuals decide whether to migrate. DYNAMIG will fill critical gaps in scientific and policymakers’ knowledge about how the decision-making behaviour of potential and actual migrants interacts with policies given micro, meso, and macro factors, e.g. different socioeconomic status. We focus on Africa as the most important future region of origin for migrants to Europe. We pursue a multi-disciplinary approach along four dimensions: First, we extend existing conceptualisations of the dynamics of migration decisions along extended trajectories and test these through innovative methods, including digital diaries collected from migrants en route from Nigeria, Kenya, Senegal, and Morocco to Europe. Second, we develop a mobile-device-based tool for online choice experiments to causally study aspiration formation across different contexts and stages of migration with several tens of thousands of individuals in origin and transit countries. Third, we study how policies affect migration decision-making with methods that allow causal interpretation: choice experiments with respondents in different contexts; a randomised controlled trial of an entrepreneurship training intervention in Senegal; and a quasi-experimental analysis of the EUTF for Africa. Fourth, through interviews with high-level policymakers and textual analysis of policy documents, we analyse how the design of EU, Member State, and relevant African policies that address migration takes into account migrant decision-making. To maximise our impact on policymaking, we embed our research in an intentional process of joint knowledge creation with stakeholders in Europe and Africa, including the policymaking community, migrant and diaspora organisations, and civil society.

Keywords: migration decision making,aspirations,capabilities,dynamics,meso level,heterogeneity and interactions,policy effectiveness,gaps in policies,causal methods,joint knowledge creation,eu,africa
Scalable Charge-transfer Artificial Lattices for Enhanced Reproducibility (SCALER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 247553.28
EU funding (EUR): 247553.28
Participants: 1
Project status: SIGNED

Project SCALER (Scalable Charge-transfer Artificial Lattices for Enhanced Reproducibility) aims to advance and democratize quantum materials engineering. In an era where quantum technologies promise revolutionary advancements, the need for reliable, scalable methods to study and manipulate quantum materials is critical. Our research objective is to develop a reproducible platform for creating artificial superlattices in two-dimensional materials, making advanced quantum research more accessible to the broader scientific community. Current approaches like moiré superlattices and cold atom systems, while valuable, face limitations in scalability and real-world applicability. SCALER combines two main techniques to address these challenges: 1. Refining high-resolution electron-beam lithography methods. 2. Utilizing thermal probe lithography to create "charge-transfer superlattices." This two-year project, hosted at the Technical University of Denmark (DTU), will involve close collaboration with experts in nanofabrication, materials science, and quantum physics. We aim to achieve sub-20 nm resolution in patterning, demonstrate charge-transfer superlattices, and explore new quantum states in engineered 2D materials. The expected scientific impact includes advancing fundamental quantum research. By focusing on scalability and reproducibility, SCALER aims to provide tools that researchers across various institutions can reliably use and build upon, potentially accelerating progress in the field of quantum materials. For me as a researcher, this fellowship represents a crucial step towards becoming an independent research leader. It will enhance my expertise in advanced lithography techniques, project management, and interdisciplinary collaboration. The training provided by DTU, including courses in teaching and grant writing, will further develop my skills as a well-rounded scientist capable of leading innovative research projects in the future.
In-situ fetoscopic 3D bioprinting for spina bifida treatment (3D.FETOPRINT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy,Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1972500.0
EU funding (EUR): 1972500.0
Participants: 2
Project status: SIGNED

Currently available pre-birth surgical treatments for Spina Bifida Aperta (SBA) still do not provide a complete recovery in babies and would potentially benefit from a tissue engineering approach, indeed the first clinical trial using stem cells for SBA has recently started, however this is performed via an open-uterus approach. This made me wonder, what if we can develop an innovative system to deliver via fetoscopy a bioprinted tissue engineering costructfor SBA repair? Such an approach would promote tissue regeneration and ease the surgery. In 3D.FETOPRINT I will develop a system for the in-situ fetoscopic bioprinting of a gel composed of extracellular matrix (ECM) proteins and amniotic fluid stem cells (AFSCs) to close the defect of spina bifida aperta (SBA) in a large animal model. The project will be divided into three work packages. First work package will address the development and testing of the gel, by studying the interaction between fetal ECM proteins and AFSCs, to define a gel formulation that could be bioprinted in-utero. Second work package will focus on the design and development of an innovative fetoscopic bioprinting device capable of bioprinting a gel patch on the fetus. Last work package will finally validate the innovative approach. We will first validate through in-vitro testing using a laparoscopic simulator, then we will perform a sheep spina bifida aperta model where the innovative fetoscopic 3D bioprinting system will be vaildated. We will leverage my expertise in biomaterials, cells and tissue engineering device design to carry out this project that will deliver a revolutionary system that will open up the possibility to bioprint tissue engineered constructs on the fetus.

Keywords: tissue engineering,bioprinting,biomaterials
Predictive algorithms for simulating quantum materials (Quantum Algorithms)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Poland
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-06-01
End date: 2030-05-31
Duration (months): 60.0
Total project cost (EUR): 3499299.0
EU funding (EUR): 3499299.0
Participants: 1
Project status: SIGNED

This project seeks to advance the field of predictive algorithms for quantum many-body systems by developing a next-generation numerical toolset. The project will focus on combining field-theory based methods for both perturbative and non-perturbative ab-initio and model systems with innovations in tensor techniques, quantum Monte Carlo, machine learning, and numerical analysis. By utilizing these innovative methods, we aim to deepen our understanding of quantum phases and exotic properties of materials, focusing in particular on experimentally measurable quantities. Currently, accurate methods for studying correlated quantum materials and their excitations are lacking. Established technology either employs the so-called density functional theory, which relies on uncontrolled approximations to electron correlations and may be imprecise for systems with partially filled d- or f-shells, or proceeds by downfolding to an effective low-energy model which may capture correlations but neglects import aspects of electronic structure. Recent years have seen substantial progress in methodologies for simulating finite-temperature field theories ab-initio, using diagrammatic perturbation theory and non-perturbative embedding methods. These methodologies also take advantage of advances in numerical mathematics, computer science, and machine learning, where fast tensor algorithms such as tensor cross-interpolation techniques have been developed. We believe that by combining progress in these areas it will be possible to generate a new generation of predictive and systematically improvable algorithms for obtaining experimentally measurable properties of strongly correlated quantum materials, including angle-resolved spectroscopy, neutron spectroscopy, and resonant inelastic x-rays. Ultimately, we aim to unlock new insights into the behavior of quantum materials, which will have profound implications for future scientific and technological advancements.

Keywords: quantum embedding,dynamical mean field theory,quantum impurity solvers,strongly correlated electron systems,gw,ab initio strong correlation methods,gpu simulation,tensor trains,high performance computing,quantum field theory,quantum statistical mechanics
Optimal Particle identification Of Single Site events with Underground MKIDs detectors (OPOSSUM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 1497500.0
EU funding (EUR): 1497500.0
Participants: 2
Project status: SIGNED

The observation of neutrinoless double-beta decay (0νββ) would revolutionise our understanding of neutrinos by affirming their Majorana nature and shedding light on their absolute mass scale and hierarchy. Detecting its monochromatic peak at MeV levels, with half-lives over 1026 years, is a significant challenge. Scientists are striving to push the scale of experimental exposures to tons of material per years. It is only in a background-free experiment that sensitivity scales linearly with exposure, maximising the benefits of increased detector mass. The forefront of this search lies with ton-scale arrays of bolometers at mK temperatures, such as CUORE, which investigates 0νββ in 130Te using TeO2 crystals, known for their exceptional energy resolution but plagued by background event identification challenges. With its 34% isotopic abundance 130Te emerges as the leading 0νββ candidate, bypassing the need for the now-challenged enrichment process. OPOSSUM will revolutionise event detection by outfitting 12 CUORE-crystals with six quantum limited sensors (Microwave Kinetic Inductance Detectors) and a thermistor. This innovative approach will enable discrimination of events by classifying them as Single Site or Multi Site Events. Through pulse-shape analysis, OPOSSUM is set to tag 0νββ signals with 3σ distinction from any background. This method has the potential to lower CUORE's background from 10-2 to below 10-4 counts/keV/kg/year. The success of OPOSSUM will facilitate rapid deployment within the existing setup without extensive R&D or major financial outlay. OPOSSUM-1ton is poised to become the first bolometric ton-scale, background-free experiment that can aim at surpassing the inverted hierarchy scenario, i.e. <10 meV Majorana mass. My vast experimental knowledge in low-temperature detectors is crucial for OPOSSUM's mission to push the boundaries of particle physics as per the EU Astroparticle committee recommendation for the neutrino physics programme.

Keywords: rare events searches neutrinoless double beta decay millikelvin detector low temperature calorimeters bolometers underground physics mkids low background experiments
Just Transitions for Sustainable Astronomy (SKYJUST)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 232916.16
EU funding (EUR): 232916.16
Participants: 2
Project status: SIGNED

To accelerate a just and inclusive transition towards a carbon neutral and green economy (European Green Deal) the EU is boosting its research area and heavily investing in the modernisation of its Research Infrastructures (RIs). To fill the gap on how scientific agencies are adopting transitions policies in their RIs, SKYJUST examines two intergovernmental astronomical agencies with strong European participation, the European Southern Observatory (ESO) and the Square Kilometre Array Observatory (SKAO) with multiple large-scale RIs in the Global South. These are excellent cases to produce an overview of European sustainability policies for astronomical RIs, understand the agencies’ everyday narratives and practices of sustainability transitions, provide policy recommendations, and develop an original conceptual framework bridging coloniality studies and Multi-Level Perspective on transitions. Through a pool of interdisciplinary methods SKYJUST develops an empirical analysis of how the dimensions of environmental sustainability, coloniality and governance are embedded in ESO and SKAO RIs in Chile, South Africa and Australia. Training, mobility and collaboration with world-leading scholars in transitions, decoloniality, and sustainability governance will boost my career as a world-class researcher, through courses at UU, a secondment at UCL (UK) and short visits to research centres in the Global South. Through a sound dissemination and communication strategy, SKYJUST seeks to produce an impact in the research agenda on RI’s sustainability, and deliver evidence-based policy recommendations to include a non-colonial Just Transition approach into EU’s RIs roadmaps and astronomical agencies and industry, fostering long-term sustainability partnerships between the EU and its local counterparts. The researcher's experience in transition studies and niche experiments earned in Europe and the Global South will facilitate the success of the project.

Keywords: just transitions,research infrastructures,decolonial theory,earth space sustainability
In-situ Mechano-catalysis for Polymer Activation and ConTrolled Conversion (IMPACT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1625000.0
EU funding (EUR): 1625000.0
Participants: 1
Project status: SIGNED

Less than 9% of plastic is recycled. Currently applied recycling technology yields degraded materials because undesired mechano-chemical bond cleavage shortens the polymer upon repeated processing. Here, I introduce a new type of catalyst to exploit this undesired effect to recover the polymer building blocks, the monomers, which enables the production of new high-quality polymer. I will focus on polyolefins (PP, PE) that make up 50% of polymer production and for which the state-of-the-art pyrolysis process has high energy costs and does not yield pure monomer. That is because at the 600 °C needed to break the strong carbon-carbon (C-C) bonds of PP and PE unwanted reactions occur. Adding a catalyst powder, a known strategy to exert reaction control, is inefficient for polymers because they cannot reach the active sites in the catalyst pores. I will break the C-C bonds with force instead of heat. The force is provided by collision of balls in a ball mill, a mature grinding technology that I repurpose as reactor to introduce my tunable direct mechano-catalyst: I will chemically treat the surface of the balls to create catalytic, e.g., acid, sites that are in efficient contact with polymer through vigorous ball movement. In our ground-breaking proof-of-concept experiment, we were surprised to see monomer form below 60 °C from PP, and a remarkable 4x increased activity over a traditional catalyst. To realize the full potential of this new catalytic concept, I will establish the underlying fundamental framework by A) understanding the mechanism of reactions following C-C cleavage, B) developing a predictive model of cleavage rate as a function of temperature and force and C) understanding the synergistic interplay of catalytic spheres and mechano-chemical activation. To achieve this, I will develop a new methodology for in-situ spectroscopy during ball milling in combination with radical trapping and apply the tunable direct mechano-catalysts to a variety of polymers.

Keywords: mechano chemistry,mechano catalysis,depolymerization,chemical recycling,ball milling