Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reconstructing the origin of the auxin response system (REOX)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-10
End date: 2024-01-09
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: SIGNED

Hormone signaling allow organisms to regulate their physiology. Single hormones trigger multiple and complex, context-dependent responses that evolved from simpler, ancestral pathways. A key, unanswered question is what functions were initially regulated by these ancestral pathways. In plants, auxins are key hormones that regulate multiple processes throughout the life-cycle. The three-components auxin signaling system is an excellent model of a simple pathway that generates a complex response, but it is unclear how this system has evolved. In the REOX project, I will use Charophycean algae that contain only a partial auxin response system, to reconstruct the evolutionary trajectory that allowed the emergence of the first auxin response pathway. I will study the structure, function and regulation of the closest algal orthologs of the plant transcriptional regulatory proteins, the ARFs. I will next synthetically revive the ancestral components of the pathway and assemble these into a functional response system in algae. With this, I expect to reveal the ancestral function of the auxin response system, and reconstruct the evolutionary trajectory towards hormone action in land plants. I expect this project to inspire similar strategies in the molecular evolution field. From a training point of view, this fellowship will build on my expertise on evolutionary genetics and molecular biology and allow me to complement these with skills in protein biochemistry and algal biology. This will prepare me for a future in studying evolution at different levels of complexity (molecular to ecological), and will boost my opportunities to reach an independent academic research position in this field. In summary, this projects aims to advance our understanding on the origin of hormone signalling and response evolution, and render a well-trained academic researcher with the capacities needed to develop a professional career within evolution research.

Keywords: hormones,auxins,evolution,algae,crispr,cas9
Universalism or selectivism? What citizens think about the institutional design of the future welfare state (UNI-SEL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2024-05-31
Duration (months): 24.0
Total project cost (EUR): 187572.48
EU funding (EUR): 187572.48
Participants: 1
Project status: SIGNED

Throughout the years, it has become conventional wisdom in social policy literature that universal policies, accessible to all citizens/residents, enjoy higher levels of popular support than selective policies targeted at the poor only. At first sight, the empirical evidence in support of this claim seems convincing. A large number of public opinion studies, conducted in different countries and different years, reveal the same pattern: universally targeted programs, such as most old-age pensions and healthcare systems, consistently receive higher levels of support than selective programs, such as means-tested social assistance and housing allowances. There are, however, two very good reasons why we need further research into the social legitimacy of universal vis-à-vis selective welfare. First, the studies that are typically cited to support the claim that universalism is more popular are inconclusive, because they conflate the institutional design of welfare programs with their respective target groups: the programs that are compared differ not only in terms of their design, but also in terms of the groups they target. Second, there appears to be considerable variation in public support for universalism and selectivism across countries, time, and policy domains. Therefore, the social legitimacy of universal vis-à-vis selective welfare provision remains very much an open question for future research to explore. Based on a unique combination of cross-national, experimental and longitudinal data, this project will reveal under which circumstances -when, where and why- one social policy design option is more popular than the other. In doing so, it makes a vital contribution to ongoing academic and political debates on the institutional design of the future welfare state.

Keywords: welfare state,public opinion,universalism,universal basic income,selectivism,means testing
New Nuclear Medicine Imaging Radiotracer 64Cu(II) for diagnosing Hypoxia Conditions Based on the Cellular Copper Cycle (CuHypMECH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Israel
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-09-01
End date: 2022-08-31
Duration (months): 60.0
Total project cost (EUR): 1499345.0
EU funding (EUR): 1499345.0
Participants: 1
Project status: CLOSED

Imaging of hypoxia is important in many disease states in oncology, cardiology, and neurology. Hypoxia is a common condition encountered within the tumour microenvironment that drives proliferation, angiogenesis, and resistance to therapy. Despite on-going efforts to identify hypoxia, until now there is no clinically approved imaging biomarker, due to both low tumour uptake, and a low signal to background (S/B) ratio that affects the imaging quality. Nuclear Medicine is using labelled radio-isotopes for PET/CT and SPECT imaging. These radio-tracers diagnose the metabolic processes in the body. Among these tracers, 18F-FDG is the most routinely used as a marker of glucose metabolism. However, not all tumours consume glucose, and glucose consumption is not specific only for malignant tumours, which limits its application. Copper is a nutritional metal, recently examined as a radiotracer for hypoxia, owing to its to the oxidising environment. Clinical and in-vivo studies on various 64Cu(II)-PET radiotracers resulted in controversial reports on the specificity of the current tracers for hypoxia imaging due to non-selective bio-distribution & low S/B ratio. This multidisciplinary proposal focuses on the discovery of comprehensive signal pathways of the cellular copper cycle using advanced biophysical methods and a proprietary design of 64Cu(II) radiotracer. This radiotracer will be incorporated in the cellular copper cycle, and will enable to selectively target the oxidising environment in tumours. The design of the new radiotracer is based on systematic structural & functional mapping of the copper binding sites to the various copper proteins and the visualisation of the transfer mechanism. This new copper tracer should increase the selectivity of tumour uptake, stability, and improve bio-distribution. This project assimilates cold and hot chemistry and biology, while emphasising the clinical unmet need in metal based radiotracer that form stable complexes.

Keywords: hypoxia,64cu ii radiotracer,radiopharmaceuticals,cancer,copper cycle,spect,biophysics,copper homeostasis,neurological disorders,structural biology,chemical physics of biological
Gendered Geographies of Gentrification (GGG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

This study aims to shed light on the gendered geographies of gentrification. It examines and compares the mutual reconstruction of space and gender in gentrifying neighborhoods in Amsterdam and Istanbul. It employs Henri Lefebvre’s theory of space to shed light on different dimensions (conceived, perceived and lived) of the reconstruction of space and gender during gentrification processes. The research uses a comparative qualitative methodology and combines different data collection methods (in- depth interviews, document analysis, participant observations). With its innovative use of methods and theories across disciplines and its novel focus on production of gender inequalities during gentrification, this research will contribute to the state of the art of urban and gender studies. By doing so, it will not only contribute to the excellence in science but also help increase awareness for gender inequalities, two principles promoted by Horizon 2020 Program.

Keywords: gender,gentrification,production of space,comparative urbanism,amsterdam,istanbul
Speaking Freely: Linguistic Domination, Republicanism and Federalism (Speaking Freely)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 196590.72
EU funding (EUR): 196590.72
Participants: 1
Project status: SIGNED

Linguistic diversity is a common feature of contemporary societies, leading political philosophers to question how best to approach such diversity and the conflicts it sometimes engenders. One morally significant phenomenon that linguistically diverse societies are prone to is linguistic domination. This occurs whenever a person or group is subject to uncontrolled interference over their linguistic status (the legal/official recognition of a language), conditions (the social conditions in which individuals and groups perform their daily linguistic practices) and use (the daily linguistic practices of individuals and groups) by some other person, group or political institution. Theories of linguistic justice have so far neglected the concept of linguistic domination, and one important aim of my project is to demonstrate that eliminating it is a necessary condition for linguistic justice. In addition to establishing the centrality of linguistic domination for theories of linguistic justice, my project will draw on insights from the study of federal societies to propose innovative mechanisms to address it. Federalism involves dividing political power amongst central government and sub-state units, including linguistic minorities, and as such can provide the basis for institutional remedies against domination.

Keywords: normative political theory,linguistic justice,language policies,republicanism,domination,federalism
A multipurpose solution for high resolution soil and sub-soil mapping (PetroRov)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Soil and sub-soil mineralogical composition and structures are essential features not only for agronomic purposes, already vital to assure our future, but to other important aspects. Current collected data and geochemical methods presents several limitations and restrictions as they are 1) time consuming and expensive; 2) Sampling cannot be carried out in high density spot sites and in different seasons; 3) Samples transferred to remote laboratories may lose their original properties; 4) Analytical data of the same specimens from different labs may show strong inter-lab variation; and 5) Need high manpower and time investment. Therefore, the market needs focusing on improving soil testing methods by introducing new testing all-in-one concept machines/tool to save time, money and energy. PetroLogic Synergy srl (PLS) innovative start-up, established on May 2015, is a spin-off of the Università degli Studi di Siena (Italy), created PetroRov. PetroRov is an innovative tool for soil analysis deploying internet of things technology, assembled in a modular way, "customizable" in several varieties depending on the desired needs, with sensor configurations optimized for integrated multi-parametric collection of numerous soil properties (soil and subsoil). PetroRov has applications in countless economic and scientific sectors. So far, PLS plans to present PetroRov in four different versions: AGRIPetroRov for agriculture and precision agriculture, AMBPetroRov for environmental monitoring, MINPetroRov for geotechnics, civil engineering, and mining exploration and ARCHEOPetroRov for preventive exploration archaeology. Considering that soil testing equipment market will register a growth of 4% CAGR by 2023, PLS expects to begin PetroRov commercialization by year 2022, to obtain a return of investment of R.O.I. (5 year) = 7.53 and 10 new jobs for the company.

Keywords: soil analysis,soil mapping,sub soil mapping,geochemical methods
Sexual Commitment of Malaria Parasites: Investigation Into the Epigenetic Control of Plasmodium Gametocytogenesis (SECOMAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Malaria is one of the major threats for human health worldwide and caused by unicellular organisms of the Plasmodium genus. Within their mosquito vector and human host malaria parasites replicate almost exclusively asexually. In order to be transmitted to mosquitoes formerly asexual parasites instead develop into gametocytes, which are the only forms that can infect mosquitoes. Understanding the switch of asexual to sexual replication could offer new routes towards therapeutic intervention in sexual development and transmission. However, the molecular details of commitment to gametocytogenesis remain largely unknown, and only recently the AP2-G transcription factor was identified as master regulator of gametocytogenesis. Gametocyte formation is a dead end for enduring infection and therefore sexual commitment has to be suitably regulated to ensure prolonged infection and transmission at the same time. The proposed research project aims to elucidate the epigenetic mechanisms which controls gametocytogenesis in malaria parasites infectious to rodents and humans, and intends to identify key molecular factors which regulate repression and activation of the ap2-g locus. The project will shed new light on the molecular mechanisms controlling sexual commitment and general gene expression in Plasmodium, with implications for therapeutic intervention in transmission and development of malaria parasites.

Keywords: plasmodium,sexual development,epigenetics,histone modifications,gametocytogenesis
Control for Orbit Manoeuvring through Perturbations for Application to Space Systems (COMPASS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-08-01
End date: 2022-04-30
Duration (months): 69.0
Total project cost (EUR): 1499020.97
EU funding (EUR): 1499020.97
Participants: 1
Project status: CLOSED

Space benefits mankind through the services it provides to Earth. Future space activities progress thanks to space transfer and are safeguarded by space situation awareness. Natural orbit perturbations are responsible for the trajectory divergence from the nominal two-body problem, increasing the requirements for orbit control; whereas, in space situation awareness, they influence the orbit evolution of space debris that could cause hazard to operational spacecraft and near Earth objects that may intersect the Earth. However, this project proposes to leverage the dynamics of natural orbit perturbations to significantly reduce current extreme high mission cost and create new opportunities for space exploration and exploitation. The COMPASS project will bridge over the disciplines of orbital dynamics, dynamical systems theory, optimisation and space mission design by developing novel techniques for orbit manoeuvring by “surfing” through orbit perturbations. The use of semi-analytical techniques and tools of dynamical systems theory will lay the foundation for a new understanding of the dynamics of orbit perturbations. We will develop an optimiser that progressively explores the phase space and, though spacecraft parameters and propulsion manoeuvres, governs the effect of perturbations to reach the desired orbit. It is the ambition of COMPASS to radically change the current space mission design philosophy: from counteracting disturbances, to exploiting natural and artificial perturbations. COMPASS will benefit from the extensive international network of the PI, including the ESA, NASA, JAXA, CNES, and the UK space agency. Indeed, the proposed idea of optimal navigation through orbit perturbations will address various major engineering challenges in space situation awareness, for application to space debris evolution and mitigation, missions to asteroids for their detection, exploration and deflection, and in space transfers, for perturbation-enhanced trajectory design.

Keywords: orbital dynamics,orbit perturbations,dynamical systems theory,space trajectory design,optimisation,space applications,space debris,asteroids,space transfer,phase space,low thrust propulsion
Proposal of Consortium AURASME2 for the support services Enhancing the innovation management capacity of SMEs within the Enterprise Europe Network Auvergne-Rhône-Alpes (EURORAA). (AURASME2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: France
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 213438.75
EU funding (EUR): 213438.75
Participants: 2
Project status: CLOSED

AURASME project is a subset of COSME EURORAA Consortium, based in Auvergne-Rhône-Alpes region in France. An integrated coordination within the existing activities of EURORAA consortium is ensured. Partners involved are: P1 (coordinator) CCIR Rhône-Alpes, P2 ARDI Rhône-Alpes and P4 CCIR Auvergne. P3 was not involved in this activity and is inactive since 2015 (amendment). Following the law setting new regions in France Partner 1 and 4 will merge in 1st of January 2017. Partner 2 ARDI Rhône-Alpes will approach the Agence Régionale de Développement Economique d’Auvergne and intervene in its new regional perimeter of Auvergne Rhône-Alpes. This administrative change will have no impact on the work, principles and organisation of the Consortium. The Host organizations have an expertise in key factors for the successful implementation of this activity: support of innovation projects, in particular within the framework of European projects; good knowledge and experience in European programs for SMEs; experience in promoting and supporting different management systems within SMEs (quality, security, environment, performance…); wide approach to several key aspects of innovation management and a good knowledge of the high growth potential SMEs located in the region. The general objective of this proposal is to bridge the gap of lacking innovation management capacities within the targeted SMEs in order to maximise the economic impact of ambitious innovation projects at European and International level. The work program is strictly focused on the objectives described in the call for proposal and on the implementation of the two required service packages: Key Account Management and Enhancing Innovation Management Capacity. The Work Programme describes the implementation of these two packages services, the detailed methodology and process for both service and their expected impact. A close link is maintained with the present EEN COSME related work programme.

Keywords: enhancing innovation management capacity,key account manager,sme instrument,h2020