Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deciphering Evolutionary Innovations: Comparative genomics of the origin and loss of venom in marine snails (VENORIGN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway,Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 210911.04
EU funding (EUR): 210911.04
Participants: 2
Project status: SIGNED

The VENORIGN project aims to understand the evolution of novelty in biology. A major goal of contemporary evolutionary biology is to decipher the molecular basis of major phenotypic innovations in organisms, such as winged flight in birds and echolocation in whales. However, most cases of evolutionary novelty involve complex interactions among multiple genes, each with only minor effects. To address this challenge, we turn to venomous marine snails, specifically the Conoidea group, which includes cone snails and related species. Venom in these snails is linked to a limited set of proteins called toxins, representing the primary genetic changes responsible for the shift from non-venomous to venomous animals. The long-standing interest in cone snail toxins provides a unique context for studying this transition. Yet, the origins of the conoidean venom system and the processes governing multiple venom losses remain poorly understood. This project tests the hypothesis that the origin and loss of conoidean venom resulted from rapid genomic and morphological changes and will investigate these genetic and morphological alterations driving venom's emergence and disappearance. Using cutting-edge methods spanning morphology, taxonomy, genomics, and transcriptomics, we will analyze venomous and non-venomous conoidean and related species. This comprehensive comparison will reveal the processes governing venom acquisition and loss, shedding light on the principles of evolutionary novelty. Our work extends beyond venomous snails, offering a novel model to understand the molecular foundations of significant evolutionary changes. These findings will contribute to our understanding of how novel traits emerge in various biological systems, including human pathogens and agricultural development.

Keywords: comparative genomics,venom,evolutionary novelty
Advanced Security-for-safety Assurance for Medical Device IoT (MEDSECURANCE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Maintaining an innovative, sustainable and globally competitive health industry
Action type: Research and Innovation actions
Countries involved: Cyprus,Spain,Portugal,Switzerland,United Kingdom,France,Sweden,Greece
Call: Enhancing cybersecurity of connected medical devices (HORIZON-HLTH-2022-IND-13, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 4792365.0
EU funding (EUR): 4792365.0
Participants: 13
Project status: SIGNED

Advances in healthcare IT systems have resulted in complex socio-technical architectures, which deliver integrated and patient-centered services. All these transformations, in addition to clinical benefits, they also introduce risks including security risks that need to be understood and managed, reduced to acceptable levels. There are numerous reports of new types of security vulnerabilities for this kind of architectures, which challenge the effectiveness of the current security tools. MEDSECURANCE will conceive novel methodologies, infrastructures, and technologies that enable an effective, harmonious and continuous development and evolution of secure system engineering management activities in Internet of Medical Things (IoMT). Our objective is to advance knowledge and basic understanding of decision making in diverse IoMT threat landscapes based on different system and component level interactions. This is accomplished via the development of a novel holistic strategy that considers the interdependence of several IoMT subsystems, information exchange, risk thresholds, and regulatory ramifications. We provide scalable and verifiable secure system engineering management solution(s) that capture, communicate, and act on these complexities in order to improve decision-making in cyber defence while automating cybersecurity assurance. Our solution(s) will be co-developed and validated with our medical industry user partners, and complemented by engagement of healthcare industry stakeholders in support of the recommendations to existing guidelines that will also be developed in the project.

Keywords: iomt,security,assurance,mdr
Advanced Digital Tools for Solar to Butanol Production – Hop-On (S2B-HopOn)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Finland,Greece
Call: Hop-on facility (HORIZON-WIDERA-2025-03, 2025)
Duration (months): 28.0
Total project cost (EUR): 600000.0
EU funding (EUR): 600000.0
Participants: 2
Project status: CLOSED

The S2B-HopOn project will enhance the ongoing Horizon Europe project S2B by integrating advanced digital modelling, simulation, process control and AI-driven decision support. It addresses key bottlenecks in solar-to-butanol production by introducing a new work package (WP8) focused on dynamic system-level integration, scale-up and operational optimization. Led by CERTH, the Widening partner, S2B-HopOn adds value through plant-wide Digital Twin (DT) development and real-time experimental and simulation data fusion. These tools enable realistic performance assessment under variable solar and environmental conditions. The project strengthens process resilience, circularity and sustainability, while it improves the scalability and deployability of novel bio-hybrid photobioreactors (PBRsThe S2B-HopOn project will enhance the ongoing Horizon Europe project S2B by integrating advanced digital modelling, simulation, process control and AI-driven decision support. It addresses key bottlenecks in solar-to-butanol production by introducing a new work package (WP8) focused on dynamic system-level integration, scale-up and operational optimization. Led by CERTH, the Widening partner, S2B-HopOn adds value through plant-wide Digital Twin (DT) development and real-time experimental and simulation data fusion. These tools enable realistic performance assessment under variable solar and environmental conditions. The project strengthens process resilience, circularity and sustainability, while it improves the scalability and deployability of novel bio-hybrid photobioreactors (PBRs), CO2 capture and downstream processing (DSP) integrated systems. CERTH’s participation expands the project’s geographical relevance, bringing in expertise from Southeast Europe. It also contributes to knowledge circulation, capacity building and institutional transformation in Widening countries. Overall, S2B-HopOn reinforces the system-level excellence, impact and innovation potential of the S2B project.

Keywords: butanol,digital twin,solar fuels,bioprocess simulation,multimodal data fusion,decision support interface
EXPloring opportunitiEs for developing a risk and resilience climate service baseD on bIg daTa and machinE learning (EXPEDITE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2026-03-31
Duration (months): 31.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 4
Project status: SIGNED

Despite the urgent need for adopting multi-hazard risk approaches and for the implementation of resilience-enhancing measures in the EU and at the global scale, several challenges for effective implementation of risk assessment and adaptation responses remain. In particular, the assessment of climate hazards, risk and resilience is often based on static models which lose the appreciation of the temporal and spatial dynamics and complex feedback responses within the system. As a consequence, the information provided often fails to inform decision-makers and other end-users with the correct data to be actioned through timely responses to emerging risks. Barriers to development and implementation of novel approaches and models include the availability, cost and reliability of input datasets; the computational times and costs; the lack of consideration of the combined effect of multiple hazards; the spatial and temporal changes in the exposure of assets and services; and the complex adaptive responses of government, society and the environment to emerging risks. EXPEDITE aims at exploring new pathways to reduce and remove these barriers by exploring, testing and deploying machine learning and data science techniques and by developing and testing a climate service prototype, tailored to end-users. These may include institutional clients (such as Regions) the private sector or individual consumers. The research project, which will last 24 months, will be mainly conducted at CMCC@Ca’Foscari in Venice (Italy) under the supervision of Prof. Andrea Critto, with targeted secondments for advanced training in machine learning and data science at MALGA, University of Genoa and for climate service design and prototyping at GECOsistema srl, a specialised R&D consulting lab. A targeted dissemination and communication plan will allow EXPEDITE to share the research activities, outcomes and outputs with researchers, policymakers, the private sector and the general public.

Keywords: climate service machine learning big data climate hazard risk resilience
Joint Sensing and Communications for Future Interactive, Immersive, and Intelligent Connectivity Beyond Communications (INSTINCT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Germany,Greece,Finland,France,Spain
Call: Wireless Communication Technologies and Signal Processing (HORIZON-JU-SNS-2023, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 4170082.51
EU funding (EUR): 3999552.76
Participants: 16
Project status: SIGNED

The INSTINCT project is going to enable globally sustainable, interactive, immersive, and intelligent ‘beyond communications’ 6G connectivity by developing three complementary but critical breakthrough technology pillars: ·sensing-assisted communication technologies, thus allowing localization, tracking, mapping, monitoring, imaging, incident detection and semantics become integral parts of connectivity services (Pillar 1), ·intelligent surfaces, holographic radios and cell free systems, which offer wavefront engineering functionalities and tuneability of the wireless environment and can act as reconfigurable and intelligent sensors (Pillar 2), and ·Machine Learning (ML) techniques-based co-design of Sensing and Communications INSTINCT proposes a revolutionary path to 6G and has the ambition to specify the relevant KPIs/KVIs, formulate suitable models, devise the theoretical framework, invent new technologies, evaluate via simulations and validate by means of 2 HW and 1 SW demonstrators, a networked intelligence concept able to meet the unprecedented 6G requirements. To realise this vision, INSTINCT consortium brings together all relevant stakeholders from across Europe, with an impressive record of interdisciplinary research excellence, technology innovation, standardisation and transfer, and implementation expertise.

Keywords: 6g systems,6g connectivity,beyond communications,joint communication and sensing,reconfigurable intelligent surfaces,ai,machine learning
Nanoprobes for Nonequilibrium Driven Systems (NanoNonEq)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

At the core of far-from-equilibrium biological activity lies an orchestra of molecular motors, constantly dissipating energy while converting chemical fuel into mechanical work. Estimating the amount of the free energy budget lost to dissipation is crucial for a deeper understanding of the underlying nonequilibrium dynamics and for unravelling the thermodynamic constraints on the possible biological processes. Although there are theoretical tools for quantifying nonequilibrium activity and dissipation in the framework of stochastic thermodynamics, there is a gap between these analytical calculations and their experimental applicability. The difficulty stems from the limited accessibility to the myriad degrees of freedom of complex systems and the finite measurement resolution, which can mask the footprints of nonequilibrium dynamics, such that they may appear as passive thermal fluctuations. I will address this challenge both experimentally and theoretically. In my lab, I will develop fluorescent nanosensors for unveiling microscopic activity otherwise inaccessible in complex biological systems. Fluorescent single-walled carbon nanotubes with tailored functionalization will transduce molecular-motor activity to a modulation of the emitted fluorescence, providing a novel degree of freedom never before exploited as a phase-space coordinate for inferring dissipation in nonequilibrium systems. I will incorporate the nanotube sensors in minimal biomimetic models of active systems, including DNA-gel and reconstituted cytoskeleton driven by molecular motors, to demonstrate my approach in a highly controlled environment. Further, I will internalize the nanotubes within live cells, and utilize the fluorescence signal to estimate the dissipation in nonequilibrium intracellular organization. In parallel, I will advance theoretical tools for estimating the dissipation from experimental data, based on an approach I have pioneered for detecting time-irreversibility.

Keywords: nonequilibrium statistical mechanics,stochastic thermodynamics,single walled carbon nanotubes,fluorescent nanosensors
Crisis-Resilient Price Discovery in Decarbonized Power Systems (CRISP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-12-01
End date: 2029-11-30
Duration (months): 60.0
Total project cost (EUR): 1499490.0
EU funding (EUR): 1499490.0
Participants: 2
Project status: SIGNED

Can we turn the Energy Crisis into an opportunity that advances the clean energy transition? Yes, we can, and we pave the path leading to just and equitable decarbonization. Debates that followed extreme events in Europe and the US pointed to a “wind of change” for the power market design and the price discovery process. Operators are put in the corner, inheriting market schedules that they more and more amend using their judgement, whereas they are also accountable for their out-of-market decisions. The process is inherently sub-optimal and costly! Extreme events may turn annual market revenues into daily energy costs! I will explore innovative ideas in Generalized Linear Programming and adaptive robust optimization with data-driven uncertainty sets, to support network and reliability related operator decisions, and novel machine learning developments to remove computational barriers while maintaining interpretability. Tackling major obstacles that derive from non-convexities, externalities, and uncertainty (to date open problems), leveraging demand adaptability, and combining optimization with economic theory, I will break new ground by (i) defining efficient, adaptive, and robust prices that minimize the gap between market outcomes and operator decisions, and (ii) designing innovative protection mechanisms that dynamically delineate the (blurred) boundaries between systems and markets encoding crisis resilience and shielding from catastrophic financial impacts. CRISP will break the barriers that have restricted power markets to “half-markets” for more than 30 years tapping adaptable demand and set the foundations for efficient scheduling and correct investment signals in innovation, infrastructure, resource adequacy, and sustainability. The theoretical and computational breakthroughs will benefit a wide class of problems (scheduling, routing, and others) and are also relevant to integrated grids and systems hampered similarly by climate change and extreme events.

Keywords: power systems markets,price discovery,non convexities,externalities,uncertainty,adaptable demand,generalized linear programming,interpretable machine learning,optical classification trees
Robust Automated Driving in Extreme Weather (ROADVIEW)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Innovation actions
Partnership: CCAM (co-programmed)
Countries involved: Sweden,Finland,Germany,Türkiye,France,Switzerland,United Kingdom
Call: More powerful and reliable on-board perception and decision-making technologies addressing complex environmental conditions (CCAM Partnership) (HORIZON-CL5-2021-D6-01, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 8014105.55
EU funding (EUR): 6652915.8
Participants: 19
Project status: SIGNED

Complex environment and traffic conditions have major impact on the safety and operations of Connected and Automated Vehicles (CAVs). Weather affects not only the vehicle performance but also the roadway infrastructure, thereby increases the risk of collision and traffic scenarios variations. So far, most automated vehicles have been primarily trained and tested under optimal weather and road conditions with clear visibility. However, the systems will have to prove that they are equally reliable and accurate under any weather and road condition before they can see widespread acceptance and adoption. ROADVIEW integrates a complex in-vehicle system-of-systems able to perform advanced environment and traffic recognition and prediction and determine the appropriate course of action of a CAV in a real-world environment, including harsh weather conditions. ROADVIEW develops an embedded in-vehicle perception and decision-making system based on enhanced sensing, localisation, and improved object/person classification (including vulnerable road users). ROADVIEW ground-breaking innovations are grounded on a cost-effective multisensory setup, sensor noise modelling and filtering, collaborative perception, testing by simulation-assisted methods and integration and demonstration under different scenarios and weather conditions, reaching TRL 7 by the end of the project. ROADVIEW implements the co-programmed European Partnership “Connected, Cooperative and Automated Mobility” (CCAM) partnership by contributing to the development of a more powerful, fail-safe, resilient and weather-aware technologies. The consortium is a perfect combination of leading universities in the field and research institutes, high-tech SMEs, and strong industry leaders. Beyond their research excellence, the consortium members bring a unique portfolio of testing sites and testing infrastructure, ranging from hardware-testing facilities and rain and wind tunnels to test tracks north of the Arctic Circle.

Keywords: autonomous vehicles,ai,complex environmental conditions,ccam,sensor fusion,object detection,x in the loop,vru,perception,decision making system
Ceramic Advanced Manufacturing for Industrial Innovation (CRAMIO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 1351000.0
EU funding (EUR): 1351000.0
Participants: 1
Project status: SIGNED

Cramik Additive Solutions is transforming the technical ceramics market with its disruptive Cramio technology, enabling scalable, cost-effective, and environmentally sustainable additive manufacturing (AM). Our patented hyperbinder technology allows ceramic materials to be seamlessly integrated into standard 3D printing systems, removing the need for costly proprietary equipment. This innovation opens new possibilities for high-performance applications across aerospace, healthcare, and energy sectors while overcoming the high costs, complexity, and environmental concerns of traditional ceramic manufacturing. With the support of the EIC Accelerator, Cramik plans to scale production from the current 3,500 kg/year to 4,500 kg/year by 2027 and 12,000 kg/year by 2031, meeting the €4.5 million sales projection. These investments will also establish a second production facility and expand R&D capabilities. Our market entry strategy targets a €3 billion ceramic AM market, focusing on aerospace, medical, and renewable energy applications. Cramik aligns with the "Safe and Sustainable by Design" framework, leveraging Lifecycle Analysis (LCA) to reduce emissions, resource use, and waste. The company is committed to using 100% EU-sourced raw materials, enhancing supply chain resilience and contributing to EU strategic autonomy. By addressing key challenges such as material limitations, complex processing, and high production costs, Cramik is positioned to redefine the technical ceramics industry. Through collaborations with global leaders like FIVEN-KYMERA, CERAMARET, and YUGYOKUEN CERAMICS, as well as partnerships with AM equipment manufacturers like Bambulab and Prusa, Cramik is driving adoption and ensuring market alignment. This integrated approach, supported by €1.35M EIC funding, will secure technological leadership and accelerate the transition to advanced, scalable, and eco-efficient ceramic manufacturing.

Keywords: advanced ceramics,additive manufacturing,hyperbinder technology,scalable production,sustainability,cost efficiency,eu sourced materials,lifecycle analysis lca,