Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Making and Unmaking the Emperor. The use of ritual and cultural standard practices to elevate and denigrate emperors in ancient Rome (46 BC – AD 395) (UNMEMP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-09-09
End date: 2011-09-08
Duration (months): 24.0
Total project cost (EUR): 152264.95
EU funding (EUR): 152264.95
Participants: 1
Project status: CLOSED

In this project, I first of all want to examine the ways in which Roman emperors used ritual and cultural standard practices to elevate their position and legitimate their rule. The focus will be on standard practices which took place in the public or semi-public sphere, such as banquets and sacrifices. These standard practices bore meaning in several fields, including the military, civic, political and religious spheres. They were very visible to the Roman public and were advertised in imperial propaganda. In addition, I also want to examine the opposite, i.e. how ritual and cultural standard practices were used to attack Roman emperors. In their works, hostile authors from the Roman elite could transpose standard practices which aimed to elevate the ruler to different contexts, presenting them as negative and casting the emperor in an unfavourable light. The main question is: how did ancient authors transpose ritual and cultural standard practices that were in use as means of imperial representation into their negative reverses, thus delegitimising rulers they did not like? A connected second question is: which ritual or cultural standard practices were most frequently used in this respect? My research will make use of diverse source material, including several forms of literature – historiography, biographies, plays, poems and panegyrics – as well as coins, inscriptions, papyrus texts and architecture. I will examine Roman rulers from the time of Julius Caesar to the definite division of the empire in an eastern and western part (46 BC – AD 395). The project aims to contribute to the current discourse on ritual and cultural standard practices in representations of power and status. Study of this topic could reveal much about the limits of imperial power, the underlying discourses from which the standard practices in question took their meaning, and their relative importance in imperial representation.

Keywords: humanities,history,ancient history,social sciences,cultural studies,roman civilization,political culture,ritual dynamics
Polynuclear manganese and manganese calcium complexes: searching for water oxidation catalysts. (WATEROX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Sweden
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-03-01
End date: 2012-01-31
Duration (months): 35.0
Total project cost (EUR): 178089.77
EU funding (EUR): 178089.77
Participants: 1
Project status: CLOSED

The project deals with the synthesis and characterization of polynuclear Mn and Mn/Ca complexes as potential water oxidation catalysts. The “direct synthesis” approach in which zerovalent metals or metal oxides are employed as starting material will be used for the preparation of the polynuclear complexes. The isolated complexes will be identified by analytical methods (atomic absorption, CHN-analysis) and characterized by IR, UV-Vis, EPR spectroscopy, magnetochemistry, electrochemistry and single crystal X-ray diffraction analysis. Their catalytic activity in the reaction of chemical water oxidation by Ru(III) polypyridyl complexes will be tested. In the next step of the project, an oxidant will be generated by light irradiation from a Ru(II) polypyridyl complex and a sacrificial electron acceptor. The systems, in which the photooxidant not covalently linked to the Mn or Mn/Ca complex, will be investigated focusing on oxygen evolution measurement, EPR spectroscopy for the observation of electron-transfer from the Mn catalyst to Ru photosensitizer and by laser flash photolysis for kinetic evaluation of this process. In returning phase, reactive functional groups will be introduced into the most active manganese containing complexes. These building blocks then will be employed by Consortium for the synthesis of photocatalytic dyads and triads.

Keywords: inorganic chemistry,water oxidation,mn polynuclear complexes
Ecological and evolutionary dynamics of juvenescent marine populations: a comparative study of the European hake in the Atlantic and the Mediterranean (EVOLHAKE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Norway
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-06-01
End date: 2011-10-31
Duration (months): 29.0
Total project cost (EUR): 205131.18
EU funding (EUR): 205131.18
Participants: 1
Project status: CLOSED

Much evidence shows that fishing is driving evolutionary changes in the life traits of marine fish populations. Fishing does not only decrease the abundance of populations, but also changes the genetic composition of their individuals with negative impacts on the recovery capacity, and on the functioning of the ecosystems. Moreover, fishing is removing the largest individuals from many stocks leading the fish populations mainly supported by young age classes (juvenescent populations). However, the evolutionary effects of fisheries targeting young and non mature stages (recruitment fisheries) remain unexplored. This is particularly regrettable since many fisheries continue to target smaller fish as the larger individuals are disappearing. The Mediterranean fisheries show already this scenario, with the European hake (EH, M. merluccius) being the most representative species. The Atlantic populations of EH are overexploited, yet more focused in mature individuals. Fisheries-induced adaptive studies should be based on the population sub-structure. However, to date there is not enough knowledge about connectivity among EH populations exploited in the Mediterranean, though little evidences exit in the Atlantic. In the present study I aim to elucidate the ecological and evolutionary dynamics of the EH populations in the Mediterranean and the Atlantic, by focusing on the evolutionary consequences of harvesting non-mature individuals. This proposal establishes a combination of modelling, statistical tools and genetic information. The project will be developed in a top European research centre – Centre for Ecological and Evolutionary Synthesis (CEES) at the University of Oslo – which provides highly expert background in combining genetic and evolution with ecological and climatic information. The expected results will clarify the ecological and evolutionary consequences of recruitment fisheries, and thereby contribute to the sustainable management of our marine resources.

Keywords: anthropogenic impact on ecosystems,ecology (environment and fisheries interactions),ecosystem modeling (climate change),environmental impacts (environment and fisheries interactions),animal ecology
Role of Lgi and Adam proteins in nerve development and function (ELANSCI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-07-01
End date: 2011-10-31
Duration (months): 28.0
Total project cost (EUR): 161162.47
EU funding (EUR): 161162.47
Participants: 1
Project status: CLOSED

Schwann cells (SC) are the most important accessory cells to neurons in the peripheral nervous system (PNS) and are involved in every aspect of nerve structure, function and regeneration. Dr Meijer’s group has identified a novel SC expressed factor, Lgi4, involved in nerve development and function. The Lgi4 gene is mutated in a natural mouse mutant called Claw Paw, which exhibits delayed axonal sorting and hypomyelination in the PNS. Lgi4 is a member of a small family of secreted proteins mainly expressed in the nervous system. While mutations in Lgi1 have been implicated in epilepsy in humans, virtually nothing is known about the other two members of the family; Lgi2 and Lgi3. These genes are expressed during development in primary sensory neurons, suggesting that they, together with Lgi4, are involved in diverse aspects of development and function of the PNS. Some or all of these functions could be mediated through interaction with members of the Adam (A Disintergin And Metalloprotease) family of transmembrane proteins. It has been demonstrated that Lgi1 binds to the metalloprotease inactive member Adam22. Recent results from the host laboratory have demonstrated that Lgi4, 2 and 3 also bind Adam22. Adam22 mutant mice have a phenotype that resembles that of Lgi4 mutant mice, suggesting a possible interaction during nerve development. The cellular processes and molecular mechanisms that are influenced by this interaction are at present unclear. Therefore, the major aim of this research proposal is to unravel the cellular and molecular mechanisms through which Lgi4-Adam22 interaction contributes to proper axonal sorting and myelin formation. Insight into the role of Lgi proteins in peripheral nerve development will be instrumental in developing novel therapeutic strategies to aid nerve repair and function and, in addition, will inform us about the role these proteins play in eleptogenesis.

Keywords: health sciences,neurobiology,developmental biology,lgi,adam,schwann cell,sensory neuron,myelin,dorsal root ganglia,cell culture,mouse,hypomielination,epilepsy
TOPOLOGY OF CONTACT 3-MANIFOLDS (3DCONTACT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-IOF-2008, 2008)
Start date: 2009-10-01
End date: 2011-09-30
Duration (months): 24.0
Total project cost (EUR): 193449.18
EU funding (EUR): 193449.18
Participants: 1
Project status: CLOSED

THE TOPOLOGY OF CONTACT 3-MANIFOLDS WILL BE INVASTIGATED. THE MAIN TOOLS ARE SURGERY, MORSE THEORY, HANDLE DECOMPOSITIONS, OPEN BOOK DECOMPOSITIONS, FIBERED KNOTS, CONVEXITY,HEEGAARD FLOER THEORY AND OZSVATH-SZABO INVARIANTS. ALSO 4-DIMENSIONAL MANIFOLDS WITH GEOMETRIC STRUCTURES SUCH AS STEIN FILLINGS, SYMPLECTIC FILLINGS AND LEFSCHETZ FIBRATIONS ON THEM WILL BE INVOLVED IN THE INVESTIGATION.

Keywords: contact structure,open book decomposition,heegaard floer homology,contact invariants
Proteins in cell-to-cell communication: the Eph receptors and their ephrin ligands (EPHR SIGNALING)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-05-01
End date: 2012-04-30
Duration (months): 24.0
Total project cost (EUR): 172434.64
EU funding (EUR): 172434.64
Participants: 1
Project status: CLOSED

I propose to solve the structure of Eph receptors and their ephrin ligands in an effort to gain a complete understanding of their functions and acquire knowledge and training to advance my career prospects. These proteins are located at the outer membrane of cells. When they bind, they transmit a signal into the cell that carries them, providing a means of cell-to-cell communication. They control vital aspects of life where cells have to communicate with each other, such as brain development, blood vessel formation, insulin secretion, and they play a role in many cancers. Studying their structure and signalling mechanism reveals their role in these biological processes, and provides fundamental knowledge for medical purposes. Eph receptors are type I transmembrane proteins and consist of a number of discrete domains. The crystal structures of single Eph receptor and ephrin domains are known. However, the central question of how the Eph receptor transmits a signal from the exterior of the cell into the cell interior remains unsolved. My objective is to tackle this fundamental question by finding out how the individual Eph receptor domains are arranged with respect to each other, how the binding of ephrin ligand affects this configuration, and how it relates to Eph receptor signalling. In the short term, I will use structural biology tools to examine the structure of the entire extracellular part of an Eph receptor. I have already produced preliminary data to validate the feasibility of this approach. In the medium term I will examine the structure of the extracellular part of the Eph receptor bound to an ephrin ligand. I will interpret the structural information I derive to study Eph receptor and ephrin functions. In the long term I will design and apply experimental protocols to characterize the structure of the entire transmembrane Eph receptor. This project constitutes a stepping stone from my early research to a mature and long term career in science.

Keywords: x-ray crystallography,protein expression,eph receptor,ephrin,cell-cell signaling,axon pathfinding
Developing New Approaches to the Preservation and Sharing of Africa’s Printed Heritage: the Eritrean Case (PRINTED HERITAGE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Italy
Call:  (FP7-PEOPLE-IOF-2008, 2008)
Start date: 2009-10-07
End date: 2011-10-06
Duration (months): 24.0
Total project cost (EUR): 74921.22
EU funding (EUR): 74921.22
Participants: 1
Project status: CLOSED

The research project aim at developing a new methodological and procedural approach to the preservation and dissemination of Africa’s printed heritage through the use of digital technologies. Since independence many African countries have attempted to recover their historical sources. Initially parchments, manuscripts, archival and oral source were able to get the lion share of the attention but it has gradually appeared that local printed material are rich source of information and can greatly contribute to the understanding of many aspect of the modern history of Africa. Consequently many institutions have urged more attention to this important historical source, fostering preservation readiness and recommending the compilation of national bibliographies and the recovery of printed materials. Nevertheless, many factors have hampered the achievement of this target: lack of adequate bibliographical resources, dispersion of the printed materials, extreme rarity of many of the documents and consequent impossibility to buy them on the market due to financial constraints, etc. Therefore the concrete risk that many countries are facing is that of large parts of their National printed heritage being dispersed or even destroyed within the next few decades. The project consists of a first part aimed at identifying, localizing and cataloging the printed material appeared in Eritrea between the years 1867 and 1962 (the first date coincides with the appearance of the first printed book in Eritrea, the second represent the annexation of Eritrea to Ethiopia). A second part consists in the digitalization of the identified printed material. The conclusive part consists in the creation of the National Virtual Library of Eritrea. The scientific contribution of this project is to produce a procedural approach simple, inexpensive and sustainable so as to facilitate the repetition of this experience in other African countries.

Keywords: modern and contemporary african history,colonial history,information management,bibliography,printed heritage,digital libraries
Maternal Communication with embryo (MACE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2010-09-01
End date: 2012-08-31
Duration (months): 24.0
Total project cost (EUR): 172434.64
EU funding (EUR): 172434.64
Participants: 1
Project status: CLOSED

Mechanisms of interactions of embryos with their maternal environment are important biological filters limiting reproductive success, both in livestock and the human. Although several aspects of the embryo-maternal interactome have been studied, there is so far no systematic analysis of this biological module. Increasing our knowledge regarding maternal interaction with embryos will lead to creation of novel molecular markers of fertility that will help to improve the fertility of livestock population by genomic selection and thus provide unique competitive advantages to the animal breeding industry. Knowledge of the embryo-maternal interactome will facilitate novel approaches for improving the efficiency and safety of assisted reproduction techniques. Finally, this knowledge has cross-disciplinary applications in human health and is of immense importance for future public health. No systematic studies to date have been performed to allow construction of an in-silico model for the temporal sequence of events involved in maternal communication with embryos. All investigations so far have studied this interaction in isolation, without consideration of spatial or temporal components that may confer consequences for developmental potential. Early embryonic development, implantation and maintenance of pregnancy are critically dependent for intact and efficient communication between embryo and the maternal tract. The overall objective of this application is to identify the local proteomic factors produced in porcine oviduct and uterine horn in response to developing embryo. This information will be used to construct a systemic in-silico based model of oviduct and uterine horn proteomic secretome environment and changes in this milieu, due to embryo development. For this purpose, we evaluate the oviduct secretory proteomic profile alteration in response to embryos at different stage of development.

Keywords: female reproductive tract,oviduct,embryos,spermatozoa,oocytes,secreteory proteomic profile,animal reproduction,animal breeding
Cluster, glass, and crystal formation in concentrated protein mixtures of opposite charge sign (PROMIX)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-IEF-2008, 2008)
Start date: 2009-03-01
End date: 2011-02-28
Duration (months): 24.0
Total project cost (EUR): 180801.44
EU funding (EUR): 180801.44
Participants: 1
Project status: CLOSED

Protein mixtures are essential ingredients in a multitude of natural and synthetic complex systems, such as the eye lens, the blood stream, the cytoplasm of living cells, yoghurt, and so forth. Research on protein interactions is thus pivotal to gain insight in the stability of such soft matter systems, in their structural and dynamical properties, and in their (biological) function. As nearly all of the current work focuses on interactions in relatively simple model systems (i.e., mixtures of either identical or like-charged proteins), this project will deal with cluster, glass, and crystal formation in concentrated protein mixtures of opposite charge. The project is highly original and proposed at an ideal time in the development of the field. In spite of considerable community interest, no systematic study, using (recently developed) suitable instrumental techniques and in close alliance with several European scientists who develop theory and simulations of the model systems, has been undertaken. This provides the community with a unique opportunity to link an excellent female researcher (MSc and PhD degrees were awarded cum laude) with an ideal background and proven ability to collaborate with an institution that has made major strides in this area of emerging interest and can provide the applicant with the necessary infrastructure and expertise to make this project work. As outlined in the following, the IEF fellowship will allow the applicant to gain additional scientific competencies and skills, to consolidate and extend her presentation and language skills, and to acquire additional and complementary management and leadership competencies and skills. Hence, this project will have a significant impact on the applicant’s future career prospects who is aiming to reach a position of professional maturity, diversity, and independence as her long-term goal is to establish an independent line of research within Europe in the field of life sciences.

Keywords: physical chemistry,protein,crystal,glass,cluster,dynamical arrest,coacervation,electrostatics,colloid
How biochemical networks encode biological specificity: Modulation of cell migration by isoform specific ERK and Akt signaling (BIOSPEC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland,United Kingdom
Call:  (FP7-PEOPLE-IIF-2008, 2008)
Start date: 2009-03-02
End date: 2011-03-01
Duration (months): 24.0
Total project cost (EUR): 181350.76
EU funding (EUR): 181350.76
Participants: 2
Project status: CLOSED

Understanding how biochemical signaling networks encode biological specificity is a fundamental challenge for biologists in the 21st century. Genome sequences by providing the “parts list” for such signaling networks, were expected to advance insight. However, it has become clear that to understand specificity analyzing only the “parts list” is not enough; it is the complex orchestration of these parts’s expression, interactions, activation, and deactivation in both space and time that encode biological specificity. Thus, understanding the biological specificity code requires investigating the spatiotemporal dynamics of biochemical signaling networks. This proposal focuses on understanding how the spatiotemporal dynamics of epidermal growth factor (EGF) gradient-induced signaling and associated feedback loops encode a cell’s decision to migrate and invade. A particular focus is on the isoform-specific roles of ERK1, ERK2, Akt1, and Akt2. Traditionally, these protein isoforms have been assumed to have very similar roles in the phenotypic response to EGF signaling. However, our preliminary data show that these isoforms have very distinct, opposing roles for control of EGF gradient-induced cell migration in an aggressively migrating mammalian cell line. To measure, interpret, and understand EGF gradient-induced signaling and the resultant cell migration, we propose using an interdisciplinary, systems biology approach combining modern biochemistry, quantitative mass spectrometry, live-cell imaging, spatially-resolved mechanistic modeling, and empirical data-driven modeling. Model-based experimental design will be the hub that connects modeling with experiments through an iterative model building cycle. As result we hope to gain a mechanistic understanding of how EGF gradient signals are spatially propagated through a cell, coupled with the ability to predict cell migration outcomes based on the spatiotemporal signaling patterns.

Keywords: computational biology,cell biology,molecular design,de novo design,oncology