Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Training network for exploring microalgae diversity for the development of novel antiviral compounds (AlgaeNet4AV)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Greece,Italy,Denmark,Portugal,Croatia,Spain,Japan,United States,Switzerland,Cyprus
Call: MSCA Staff Exchanges 2021 (HORIZON-MSCA-2021-SE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 973885.71
EU funding (EUR): 772800.0
Participants: 14
Project status: SIGNED

The AlgaeNet4AV project seeks to exploit the microalgae biodiversity, as a source for high-added-value lectins and polyphenols with antiviral properties against influenza and coronavirus pandemic strains. Microalgae derived-compounds are easily amendable, bio-degradable, non-toxic and safe; thus, they are preferred to be used for the development of novel bio-based materials and cosmetics with antiviral potential. Lectins and polyphenols could be highly demanded non-drug interventions across the materials and cosmetics industry as a solution to reduce the risk and speed of contamination and transmission during pandemic outbreaks. The project will combine the whole value chain in order to: a) develop transcriptomics and metabolomics resources from microalgae diversity as a valuable source for the discovery novel lectins and polyphenols; b) characterize their spectrum of bioactivity and toxicity and provide structure-function relationships; c) develop and optimize application-based microalgae culture systems and downstream processing strategies for higher production rate of the desired compounds; d) develop, formulate and evaluate lectins and polyphenols-based final cosmetics products. The work will be supported by market assessment, integral biorefinery designs, techno-economic and sustainability assessment. Integrated value chains will be demonstrated to deliver proof-of-concept and demonstrate economic feasibility. AlgaeNet4AV is an industry-academia R&D and innovation project with a multidisciplinary approach aimed at generating robust business cases through technology development. The consortium composed by 11 partners, with 7 European and 2 third-country (USA & Japan) prominent research organisations. Strong industrial leadership is guaranteed through the participation of 5 SMEs. The projects goals will be achieved through a sustainable way helping meet the increasing demand while creating a positive environmental impact through reduction of carbon emissions.

Keywords: microalgae,novel products,virus,pharmaceuticals,food,cosmetics
Pain relief in palliative care of cancer using home-based neuromodulation and predictive biomarkers (PAINLESS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Czechia,Romania,France,Belgium,Switzerland,Denmark,Israel,Portugal
Call: Improved supportive, palliative, survivorship and end-of-life care of cancer patients (HORIZON-HLTH-2021-DISEASE-04, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 5954323.75
EU funding (EUR): 5952245.0
Participants: 19
Project status: SIGNED

More than 50% of cancer patients develop pain before death: 80% can be treated with drugs, but 20% show a low response or have serious adverse effects. Although non-pharmacological interventions such as neurosurgical procedures have been tested, these alternatives are not a preferred option to treat cancer pain due to their high cost, risk, invasiveness and not always proven efficacy. PAINLESS addresses a core component of pain relief, by using an innovative, evidence-based approach. The objective is to adapt and implement a novel, cost-effective, home-based intervention based on neuromodulation to reduce pain and improve quality of life of cancer patients with chronic pain. On the assumption that treatment of chronic pain can benefit from research on the brain mechanisms of pain, we will first attempt to improve our understanding of the role of central pain modulation. The project will be organized in 3 studies: 1) A cohort, longitudinal study (n=450) to explore whether the biomarkers of central pain modulation mechanisms can be predictive of the future occurrence of chronic pain in cancer patients; 2) A cross-sectional study to characterize and stratify cancer patients with vs. without chronic pain (750 patients with the proposed biomarkers and taking into account a number of moderator variables); 3) A pilot study (n=450) to assess the feasibility an efficacy of at-home delivery of transcranial low intensity electric stimulation (tES) for the palliative care of cancer patients suffering from pain PAINLESS will develop a customized web portal to share knowledge and to improve management of the patients; perform techno-economic analyses and Health Technology Assessment of the solution; analyze the possibilities of implementation in different European healthcare systems and results exploitation; and undertake an ambitious dissemination and communication strategy. We will also propose a wide range of measures to ensure compliance with the highest ethical standars.

Keywords: cancer pain,central pain modulation,predictive biomarkers,neuromodulation,home based treatment,palliative care
Regional mobility infrastructures (REMOBILISE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

REMOBILISE will be the first, interdisciplinary study examining the relationship between mobility infrastructures and free movement in West Africa. In bridging legal studies, citizenship studies, and infrastructure studies it aims to unpack how mobility infrastructures impact free movement in West Africa – and with what consequences. Free movement is recognised as a key driver for economic development, poverty reduction, and livelihood strategies. The Economic Community of West African States (ECOWAS) was among the first organisations to introduce a regional free movement regime in 1979. Yet, immense disparities continue to exist in terms of who can access this seemingly equal right in practice. Although studies have indicated that legal, technological, and physical impediments may result in variegated access to free movement, there remains a lack of knowledge on the impact mobility infrastructures have on free movement. The project seeks to address this knowledge gap through the study of three complementary work packages focusing on the research questions on manifestations, patterns, and consequences of mobility infrastructures. It will use a mixed method approach, innovatively combining ethnographic approaches with legal research and large-scale data analysis. The project contributes to key debates in legal studies, citizenship studies, and infrastructure studies, specifically by improving the emerging scholarship on mobility infrastructures. The findings have direct impact on the lives of over 400 million people living in the region, on the work of ECOWAS policymakers, and on external partners, such as the UN and the EU.

Keywords: ecowas citizenship mobility infrastructures free movement data analysis
Dynamic mapping of epigenetic regulation during embryogenesis using in vitro stem cell model (DyMERE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-08-15
End date: 2026-08-14
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

This proposal aims to decipher the dynamic regulatory landscapes of chromatin modifiers during embryogenesis. In particular, I envision to unravel their mechanism of action at unprecedented resolution using single-cell based techniques, and provide novel insights on the molecular deregulation that leads to diseases such as cancer. The originality of this approach is to simultaneously address the function of hundreds of chromatin modifiers in early development by using a higher throughput, stem cells-based in vitro screen. In order to achieve this, we will take advantage of a recently established culture system that faithfully recapitulates embryonic development up to somitogenesis in the dish. The combination of various cutting-edge techniques with this model (Cas9-based screening, targeted protein degradation, low input CUT&RUN and single cell RNA-seq) and our sophisticated computational strategies will allow a precise understanding of how various chromatin regulators act on specific targets in individual cell. In particular, we will resolve gaps of how two essential, global modifiers, Polycomb repressive complex 1 and 2, cooperate to regulate distinct cell identity decisions. Ultimately, we will hope to reconstruct the hierarchal dynamics of chromatin regulators at a temporal and spatial resolution of single cells through embryogenesis. The result of this action will be shared with scientific community by open-access peer-reviewed journals, conferences, analytic codes and sequencing data; and with general public through Open Science Days. The Meissner laboratory will provide the ideal environment not only to carry out this project, but also expand my scientific expertise and train my skills to better prepare me to become an independent group leader in the future.

Keywords: synthetic embryos,epigenomics,molecular genetics
Sicilians dreAmIng Louisiana: Agents of Migration and Labour Recruiters on the Palermo-New Orleans Route (1865-1901) (SAIL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: SIGNED

SAIL analyses early migration from Sicily to Louisiana between 1865 and 1901. It sheds light on agents of migration who enrolled peasants in Sicily and on their transnational connections with labour recruiters based in Louisiana, who were looking for a labour force after the abolition of slavery at the end of the US Civil War in 1865. On the other side of the Atlantic, the Italian government considered emigration as an issue to be managed or opposed: the 1901 law restricted the activity of agents of migration, who were regarded as people smugglers and used as a scapegoat to justify migration, rather than being studied as one of the interrelated factors triggering it. This simplistic view permeated the public debate in Italy, has not been challenged by scholarship on Sicilian migration, and resonates with current populist and xenophobic narratives. SAIL offers the first comprehensive study of early Sicilian migration to Louisiana by adopting an interdisciplinary approach combining social, economic, and cultural history with literature. Thanks to a thorough investigation and cross-referencing of untapped Italian and US archival sources and literary works, SAIL maps the presence of agents of migration in Sicily, analysing their identity, background, methods, organisation, and the transnational connections with labour recruiters in Louisiana, gauging their effectiveness in disseminating a dreaming image of the USA among Sicilian peasants and examining the extent to which their activity impacted the migration flow alongside other factors (economic depression, political turmoil, chain migration, remittances). SAIL will fill a scholarly gap, develop tools for researching migrations, and reflect on Sicily’s past and its present as one of the main gateways into Europe. Through activities involving academic and non-academic audiences, SAIL will stimulate a debate and raise awareness around one of Europe’s most pressing concerns: safeguarding the right to safe migration.

Keywords: migration history history of italian migration history of labour migration
Coastal carbon release driven by tidal meander migration (CarbTMM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,Netherlands,Japan
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-28
End date: 2026-10-27
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 3
Project status: SIGNED

Coastal carbon release is drawing escalating concern globally, primarily because of its adverse effects on climate change mitigation and the pursuit of carbon neutrality. Driven by outer bank collapses, tidal meanders frequently migrate across coastal landscapes, revealing sediment layers that would otherwise remain concealed. This exposed sediment is rich in organic carbon, which is released back to the atmosphere upon oxidation. Despite the significance of this mechanism, a notable research gap exists in linking coastal carbon release to the intricate dynamics of tidal meander migration (TMM). This void can be attributed largely to the challenges of accurately simulating TMM. To bridge this research gap, CarbTMM aims to unravel the mechanisms underlying TMM and to understand its influence on coastal carbon release. The proposal will address four pivotal objectives. Firstly, investigate the mechanisms of bank collapse in tidal environments through physical experiments, and formulate parameterized, physics-based functions that accurately capture characteristics of such collapse events. Secondly, refine the start-of-the-art morphodynamic models by integrating newly developed functions for bank collapse, to better simulate the evolution of single tidal meanders (Nays2D) and complex tidal networks (Delft3D). Thirdly, formulate an idealized, process-based TMM model for global-scale applications, drawing on insights from the refined sophisticated models. Lastly, generate and evaluate projections detailing TMM-driven coastal carbon release at global scale under current and future climatic scenarios (e.g., sea-level rise). In achieving these objectives, CarbTMM aims to provide profound insights into the coastal carbon cycle and strengthen our proficiency in assessing potential capacity of coastal carbon storage. Furthermore, predicting TMM near coastal infrastructures can help protect coastal communities and their assets.

Keywords: coastal carbon release,tidal meanders,bank erosion,bank collapse,morphodynamics,tidal flats
International Study for Treatment of Childhood Relapsed ALL 2020 (IntReALL 2020)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Research and Innovation actions
Countries involved: Germany,France,Italy,Netherlands,Czechia,Norway,Romania,Finland,Hungary,Belgium,Denmark,Portugal,Israel,Slovenia,Austria,Spain,Switzerland,Greece,Poland,Sweden
Call: Pragmatic clinical trials to optimise treatments for patients with refractory cancers (HORIZON-MISS-2022-CANCER-01, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 6135176.25
EU funding (EUR): 6135176.25
Participants: 26
Project status: SUSPENDED

Relapse of acute lymphoblastic leukemia (ALL) remains a leading cause of mortality in childhood cancer. IntReALL 2020 will conduct randomized and historically controlled trials in children with relapsed B-cell precursor (BCP) ALL with the aim to replace toxic chemotherapy with better tolerated and more efficacious immunotherapeutic drugs. In standard risk (SR) patients, the CD22 directed antibody-drug conjugate inotuzumab ozogamicin (InO) will be randomly compared with standard of care (SOC) ALL-R3 induction. All patients will receive one SOC consolidation- and one Blina course, compared to historical controls. SR patients with MRD good response will receive 2 additional Blina courses replacing chemotherapy randomly compared with SOC. Patients with high-risk relapse will receive induction investigating InO versus ALL-R3 in an industry-sponsored trial, followed by IntReALL consolidation and allogeneic HSCT. Patients with isolated extramedullary (IEM) relapse are treated based on ALL-REZ BFM 2002 backbone. IntReALL 2020 will establish a federated relapsed/refractory leukaemia board generating personalized recommendations based on clinical, molecular-genetic and drug response profiling data. Patients with very-high risk disease will receive experimental/personalized therapies, including a trial investigating CD19-directed chimeric receptor antigen (CAR) T-cells produced in academic institutions. Other CAR T-cells trials as well as an induction trial for T-ALL relapse will be developed. Documentation and monitoring of the trials and the individualized treatment will be realized using the MARVIN database. Comprehensive statistical and data management activities will warrant the accuracy and interpretability of the data. IntReALL 2020 involves representatives from participating pharmaceutical companies and EMA as well as patient/parent advocates to discuss strategies for developing new drugs within academic trials warranting a benefit for all patients on the results. “This action is part of the Cancer Mission cluster of projects on ‘Diagnosis and treatment’.”

Keywords: lymphoblastic leukemia clinical trial immunotherapy tumor board stem cell transplantation relapsed
Regional Innovation Valleys for Circular economy (RIVCircular)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: COFUND actions
Countries involved: Spain,Norway,Slovakia,France,Germany,Ukraine,Belgium
Call: Implementing co-funded action plans for connected regional innovation valleys (HORIZON-EIE-2023-CONNECT-03, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 20862460.0
EU funding (EUR): 10431230.0
Participants: 10
Project status: SIGNED

In line with the new European Innovation Agenda’s flagship on accelerating and strengthening innovation in European Innovation Ecosystems across the EU and addressing the innovation divide, the RIVCircular project proposes the collaboration of six European regions in southern (Madrid), central (Haut de France), northern (Innlandet and Brandenburg) and eastern (Kosice and Kiev) Europe in the field of the circular economy. The RIVCircular project will focus its actions on five key priorities, of great interest to the participating regions, of the circular economy. These are: • Construction and Demolition Waste (CDW) circularity. • Waste- Resource and energy recapture. • Electric Vehicle (EV) batteries recycling. • Circular economy in the textile industry. • Improving the digitization of the circular economy The RIVCircular consortium will develop two types of activities: • Competitive selection and funding (joint open calls implemented via financial support to third parties - FSTP) of six interregional innovation calls in the circular economy area, including deep tech, linked to key priorities mentioned above. • A consistent set of core collaborative activities to improve the connections and cooperation between the participants regions with a different innovative profile: o Community of Madrid and Brandenburg are strong innovator. o Innlandet and Hauts de France are moderated innovator o Kosice and Kiev are emerging innovator Collaborative activities will be developed in the following areas: • Networking and coordination structures and tools to facilitate innovation development. • Support for local innovation hubs networking. • Capacity and skills building. • Joint procurement initiatives. • Integration of social innovators and civil society. • Identifying market-access barriers and enablers.

Keywords: circular economy
Motivations, experiences and consequences of returns and readmissions policy: revealing and developing effective alternatives (MORE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Belgium,Slovenia,Greece,United Kingdom,Denmark,Sweden,Germany
Call: Return and readmission of irregular migrants in the EU (HORIZON-CL2-2022-TRANSFORMATIONS-01, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 2757703.75
EU funding (EUR): 2757703.0
Participants: 11
Project status: SIGNED

In recent years, the Returns and Readmissions policy has become the preferred solution for the EU and its member states to address migrants living in situations of irregularity. Yet, different actors have raised concerns over the lack of effectiveness of the policy, violations of migrant’s fundamental rights associated with its implementation and the dependency on third countries for its application. In the first phase of the project, MORE will provide an exhaustive analysis of the development of the policy and its supporting evidence to understand why it has become a preferred solution and why it has been understood to be ineffective. In parallel, the project will examine the development, rationale, objectives, supporting evidence and implementation for 6 alternative policies that are or have been implemented in EU member states and the UK. The project will look at when and why these are or were implemented and why they have not become the main response to situations of administrative irregularity among migrants in the EU.

Keywords: irregular migrants returns and readmissions policy