Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Extreme Mechanics of Metamaterials: From ideal to realistic conditions (Extr3Me)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 1499478.0
EU funding (EUR): 1499478.0
Participants: 1
Project status: SIGNED

Manipulating physical signals such as light, sound, heat or motion is a vital challenge in multiple areas of science. Due to recent advances in digital fabrication techniques, the last years have seen a revolution in artificial periodic composites with on-demand electromagnetic, acoustic, thermal and mechanical properties. These so-called metamaterials become particularly interesting in mechanics, where geometrical effects and nonlinearities are much stronger than in any other physical field. Over the past 5 years, the community -including myself- has discovered a plethora of “extreme” functionalities, e.g. mechanical metamaterials that are very light, stiff and strong at the same time, that have negative elastic moduli or that exhibit programmable shape-changes. Importantly, such advanced properties are typically designed through a purely geometrical framework. Yet, this impressive progress is so far confined to idealized settings, namely for homogeneous boundary conditions, imperfection-free structures and purely elastic constituents under quasi-static driving. This traditional focus severely limits our understanding of metamaterials and their potential for applications. Here, I propose to uncover the extreme mechanics of metamaterials under realistic conditions. Specifically, by generalizing the geometrical framework to allow for deviations from the ideal limit, and by validating it through a wide array of experimental and numerical techniques, I will establish: 1) the effect of inhomogeneous boundary conditions; 2) the sensitivity to geometric imperfections; 3) the role of dissipation. Just as the fundamental understanding of defects and dislocations revolutionized materials science, by exploring perturbations in metamaterials I will push the frontiers of solids mechanics and open up avenues for the design of robust advanced functionalities tailored to realistic complex scenarios, from prosthetics to aerospace.

Keywords: metamaterials,elastic instabilities,compliant mechanisms,imperfections
Innovative solution for FMS computed trajectories validation by means of pilot actions emulation, comparison with PANS-OPS criteria and data mining techniques. (FIVER)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France
Call: Innovative validation methods and tools for FMS (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-11-01
End date: 2021-01-31
Duration (months): 27.0
Total project cost (EUR): 1218846.25
EU funding (EUR): 853192.38
Participants: 3
Project status: CLOSED

This proposal combines the skills of CGX AERO in procedure design, cartography and aeronautical software development with the expertise of SCALIAN EUROGICIEL in big data and data mining techniques to set up an innovative platform for a new philosophy of FMS trajectories validation. The consortium proposes to address first a larger scale of trajectories testing by gathering reference trajectories, directly issued from procedure designers and validated by the customers as well as providing scripts emulating pilot actions (virtual crew module), resulting in the generation of a large number of computed trajectories. CGX AERO's expertise in procedure design will allow finding out the right moments during the flight and the right places along the flight procedures where to insert the perfect and unexpected/imperfect actions from the crew, to obtain the most relevant panel of trajectories. To address the comparison between a FMS computed trajectory and a theoretical trajectory, a set of algorithms based on procedure Ground Validation (data integrity, business rules verification, ARINC 424 coding rules, 4D simulation, obstacle assessment) and on-the-fly computation of PANS-OPS Protection Areas will be defined. This will ensure finding the correct threshold beyond which an outlier comes from a procedure design issue instead of a FMS computation issue. SCALIAN EUROGICIEL's expertise in big data and data mining techniques will allow setting up a data warehouse, with data analytics tools in order to run and store the results of the millions of trajectory comparisons that will be performed.

Keywords: fms validation big data mining pans ops crew model
Enabling NAnomedicine TRANSlation (ENATRANS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Coordination and support actions
Countries involved: Israel,Germany,Italy,Germany,France,France,Portugal
Call: Networking of SMEs in the nano-biomedical sector (H2020-NMP-CSA-2014, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 1999406.25
EU funding (EUR): 1999406.0
Participants: 7
Project status: CLOSED

ENATRANS’ main objective is to network and support SMEs in translation of nanomedicine in Europe by providing a one-stop-shop service to interact and share information, experience and advice with up-to-date information and interactive tools, but also enabling personal contacts. To be successful SMEs need to understand the requirements of the complex ecosystem made up of regulatory and reimbursement agencies, as well as the requirements of large industrial companies and clinical needs. ENATRANS will gather and provide information about approval processes, regulatory authorities and agencies, clinical and market data, and specific nanomedicine value chain analysis, relevant SME support projects and organisations. ENATRANS will convert this critical information in dedicated learning programs and tools dedicated to translation of nanomedicine. ENATRANS aims at implementing the concept of a Translation Advisory Board (TAB) as central element of the ETPN White Paper. A TAB will be set-up with senior experienced translation experts to guide R&D teams (in SMEs and research institutes) along the translation process to successfully make it to clinical trials and later to the market. Promising projects identified and supported by the TAB need access to clinical centers for first studies in patients, which are able to handle the specificity of new nanotechnology based therapeutics. In addition, financial resources are needed to go pass the regulatory and scale-up processes, which often require funding from investors and/or large companies. ENATRANS will build bridges to clinical trial centers, investors and large companies. Promising projects need guidance to successfully master privileged contacts with the medical, the business or the investment community. ENATRANS will deliver special coaching sessions prior to showcasing of promising projects. Partners in ENATRANS are VDI/VDE-IT, Nanobiotix, CEA, bioanalytik-muenster, Tel Aviv University, Fondazione Don Gnocchi, TecMinho.

Keywords: networking,community building,smes,communication platform,ecosystem requirements,translation advisory board,bridge to clinics,showcase,investor,industrial uptake,training
Science and Technology in childhood Obesity Policy (STOP)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive agri-food sector for a safe and healthy diet
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Spain,Estonia,Italy,Belgium,Belgium,Croatia,Romania,Slovenia,Sweden,New Zealand,Switzerland,Finland,France,France,France,United States,Portugal,United Kingdom,Portugal,United Kingdom
Call: How to tackle the childhood obesity epidemic? (H2020-SFS-2017-2, 2017)
Start date: 2018-06-01
End date: 2022-11-30
Duration (months): 54.0
Total project cost (EUR): 10859715.16
EU funding (EUR): 9600862.88
Participants: 24
Project status: SIGNED

The STOP project will bring together a range of key health and food sector actors to generate scientifically sound and policy-relevant evidence on the factors that have contributed to the spread of childhood obesity in European Countries and on the effects of alternative policy options available to address the problem. This evidence will complement, systematise and partly reframe the findings of an established body of prior research by leveraging the latest scientific findings. The STOP project will translate the evidence gathered and generated into: a. A comprehensive set of indicators and a measurement framework for the regular monitoring of relevant dimensions of childhood obesity, its determinants and actions to address it in all European Countries; b. Policy toolkits, providing practical guidance and tools for the design and the implementation of effective and sustainable policies and actions by governments and private sector stakeholders; c. A novel, evidence-based, multi-stakeholder framework, to enable and promote a shared understanding of problems and solutions by key actors, relying on a structured process leveraging cognitive mapping and policy simulations validated by empirical data and empowering individual actors to take action within an agreed accountability and monitoring framework. STOP will generate timely, comprehensive and policy-relevant measures of childhood obesity in all European countries; it will generate new trans-disciplinary evidence of the role of key determinants of childhood obesity, emphasising the role of different environments surrounding children, from analyses of detailed multi-dimensional measurements taken on several established EU children cohorts, including epigenetic and biological mediators of obesity; it will assess the impacts of policies and actions to address childhood obesity based on observations in the same children cohorts and policy simulations of the health, social and economic outcomes of policies.

Keywords: children,adolescents,economics,health economics,health policy,intervention,cohort study,physical activity,food consumption
LINGOKIDS: Adaptive mobile platform for language learning for early age children (LINGOKIDS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2016-04-01
End date: 2016-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Because of the globalisation, language learning and bilingualism has been introduced in education from the earliest years of schooling. Recent studies show that the best age for a person to learn a second language is 2 to 6 years. Monkimun, aware of this need, is developing an ecosystem of educational game-based Apps that are based on a rigorous scientific research on the psychopedagogy of the learning process in early childhood, together with Universities and research centres. The propose LINGOKIDS project seeks to become the reference mobile platform available in the market for adaptive language learning, focus on early age children, based on multiple intelligences theory, Big Data techniques, Artificial Intelligence (AI) algorithms, and following a game-based learning methodology. The platform will be able to identify the children's learning pace during play and automatically adapt educational content for a customized learning. In addition to this, LINGOKIDS platform will provide parents and educators with tracking tools and periodic reports, and a user interface framework to co-design tailor-made lessons upon this intelligence. The envisage LINGOKIDS platform will provide parents and educators with the most innovative solution available in the market to empower early age children with a funny and motivating tool to start learning a foreign language without supervision (but monitored) in a highly customized way, attending at children learning evolution and preferences on the type of lessons (games). The global market of educational apps for children between 2 and 6 years represents 9.5% of the total market for mobile active applications, which means more than 114 million mobile apps. This market is expected to grow from $1,500 million in 2012 to $2,300 million in 2017. Through the LINGOKIDS project, we seek positioning our company as the leading player providing mobile language learning services for early age children.

Keywords: adaptive mobile platform for language learning for early age children
Novel small molecule activators of the NLRP3 inflammasome as immunostimulants (IMMUNOSTIM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-09-01
End date: 2023-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

We have identified a novel family of potent small molecule activators of the NLRP3 inflammasome. The goal of this project is to determine the feasibility of developing these new immunostimulators into an attractive commercial proposition. Establishment of technical feasibility will involve identification the most promising modifications of our drug candidates and testing their efficacy in disease models of cancer and immunization. In addition, we will determine commercial feasibility by conducting market research and competition analysis and by engaging potential industry partners.

Keywords: immunostimulator,cancer immune escape,adjuvant,small molecule drug,inflammasome,nlrp3,interleukin 1
Laws of Social Reproduction (LawsOfSocRep)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: India,United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-09-01
End date: 2024-08-31
Duration (months): 72.0
Total project cost (EUR): 1999542.0
EU funding (EUR): 1568699.46
Participants: 3
Project status: SIGNED

Feminist scholars have long demonstrated the invisibility of women’s reproductive labour, performed in bearing and raising children, maintaining households and socially sustaining male labour. Mainstream international economic institutions acknowledge unpaid care work as an obstacle to women’s economic empowerment. Sustainable Development Goal 5.4 requires that unpaid care and domestic work be recognised through provision of public services and shared responsibility in the family. However the world faces a growing care deficit even as states and international institutions fail to commit to systemic reforms and criminalise women’s economic choices. Anchored in the global South context of India, the project offers a cutting-edge, inter-disciplinary lens to retheorise the normative, empirical, regulatory and policy dimensions of the law’s regulation of social reproduction. The project broadly conceptualises female reproductive labour to include unpaid domestic work as well as sex work, erotic dancing, commercial surrogacy and paid domestic work. Placing varied forms of reproductive labour along the market-marriage continuum, the proposed project offers four main work packages: (1) Normative: Articulates a materialist feminist theory of reproductive labour, revitalises feminist legal theory on the economy through a distributional analysis of the laws of social reproduction (2) Empirical: Consolidates and supplements through new empirical research the study of the political economies and legal ethnographies of sex work, bar dancing, commercial surrogacy and paid domestic work to improve women’s economic bargaining power (3) Regulatory/Policy: Catalogues for each sector innovative economic models, legal and governance tools, policy proposals (including local experimental measures and radical blue-sky ideas) to enhance women’s economic bargaining power and (4) Political Impact: Shifts political sensibilities by dissolving discursive and policy silos between these sectors.

Keywords: feminist theory,india,women s labour
Unlocking the full potential of grarages and paving the way for 21st century garage (HomyHub)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: United Kingdom
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-10-01
End date: 2018-02-28
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

HomyHub GARAGE is a “plug and play device” for garage openers that turns any Smartphone into a smart garage remote control. Allowing users to control, monitor, and manage the access to their garage, anywhere and at anytime from their smartphone.In this 6 months project we are focusing on finding new business partners in EU countries and finalise our prototype, to make it commercial viable product. The main objective of our SME1 project is to gain proof of evidence that HomyHub’s product can be commercialized at a full speed from 2018 . For this, we have identified two important challenges to commercially fully exploit HomyHub’s product: 1) Our ambition is to become a worldwide leader in IoT devices for garage access. HomyHub is a young, fastly growing startup that is revolutionizing the world of smart mobility through delivering cutting edge technologies for garage access control. HomyHub has a balanced and very competitive founding team from Spain with strong IoT background: more than 40 years combined experience in Hardware, Firmware, Software and Business development. Our goal: to make a global business plan through the implementation of a feasibility study in this proposed Phase 1 (SMEi-1), to reach an international business uptake.

Keywords: device,garage,control,remote,access,mobile,smartphone
Metagenomic Investigation of Cow Reproductive Biology and Ecology (MICROBE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-28
End date: 2020-05-27
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

Low rates of embryo survival can be attributed to endometritis, an inflammatory disease of the endometrium lining the uterus. The disease affects ~30% of cows, increases embryo mortality by 25%4, and costs the EU and USA dairy industries €2 billion annually. The endometrium and microbiome are usually in a state of symbiosis when the cow is either receptive to pregnancy or pregnant. This symbiosis is disrupted (dysbiosis) at calving when pathogens populate the uterus. Endometritis has long term negative effects on embryo survival, but the mechanisms of how endometrium-microbe interactions affect embryo survival are unknown. The goals of MICROBE: Metagenomic Investigation of Cow Reproductive Biology and Ecology (Figure) are to (1) establish myself as an independent, internationally respected scientist in reproductive biology; (2) reintegrate into a long-term research position in Ireland after completing postdoctoral research at the University of Missouri; and (3) acquire new technical skills to broaden the scope of my research, and to expand my leadership and project management capabilities. I will be hosted by Teagasc with supervision from Dr. Stephen Butler and Dr. Paul Cotter with a secondment at University College Dublin with Prof. Patrick Lonergan. I will explore whether the endometrium and microbiome interact to affect embryo survival by testing novel hypotheses. The research objectives are to (1) examine endometrium-microbe interactions at the level of the transcriptome and metagenome of dairy cows, and test the hypothesis that such interactions are responsive to genomic selection for fertility; (2) isolate and culture specific uterine microbes from two genotypes of dairy cows divergent in fertility; and (3) use ex-vivo tissue culture systems to validate novel functional mechanisms by which uterine bacteria isolated from cows divergent in genetic merit for fertility interact with the oviduct and endometrium during sperm transport and embryo development

Keywords: dairy cow,fertility,uterus,microbiome,in vitro fertilisation,ex vivo tissue culture,embryo,reproduction