Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of deuterium metabolic imaging to map body biochemistry with MRI (BodyDMI)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Netherlands,Netherlands
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-03, 2018)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 3
Project status: CLOSED

The global obesity epidemic has resulted in a dramatic rise in metabolic diseases and the development of effective therapies has greatly lagged behind. This could arguably be attributed to a lack of non-invasive (imaging) techniques to characterize disturbances in metabolic pathways. We will investigate the use of dynamic deuterium metabolic imaging (DMI) to dynamically map body biochemistry in humans in 3D imaging mode. DMI relies on deuterium magnetic resonance spectroscopic imaging combined with oral administration of deuterium-labeled compounds. The innovation idea is linked to the MCUBE project of FET-OPEN-01-2016-2017. Here a dual-dipole coil was designed for hydrogen MRI at 7 tesla (300 MHz), which outperformed the state-of-the-art setup of the loop-dipole coil for MRI. The new design is transparent to loop designs, meaning that the setup can be combined with loop coils, which are known to be the optimal setup for low frequency operation. So for DMI, which operates at 45.7 MHz (low frequency) at 7 tesla, an MRI coil array can be designed that not only outperforms MRI, but also enables DMI at uncompromised sensitivity within the same scan session, which will complement the utilization of the MCUBE project. The objectives of the project are: (1) Build and test a body DMI setup for a clinical ultra-high field 7 tesla MRI scanner; (2) demonstrate proof of concept to measure hepatic carbohydrate and lipid metabolism with DMI; and (3) apply DMI in a clinical feasibility study in type 2 diabetes patients. Upon successful completion of the project, DMI will be valorized by the commercial partners and embedded in clinical practice, which opens up a new window for drug studies to directly image their chemical efficacy. Besides its application in metabolic diseases, DMI has potential to detect organ failure, drug toxicity and effects of cancer treatment in a much earlier stage than morphological imaging.

Keywords: magnetic resonance spectroscopy,ultra high field magnetic resonance imaging,metabolic diseases,diabetes,body metabolism,metabolic imaging
Selectively activated INFOrmation technology by hybrid Organic Interfaces (SINFONIA)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Spain,Italy,Germany,France,France,France
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-04-01
End date: 2025-03-31
Duration (months): 48.0
Total project cost (EUR): 3327678.61
EU funding (EUR): 3327678.61
Participants: 10
Project status: SIGNED

SINFONIA - “Selectively activated INFOrmation technology by hybrid Organic Interfaces” – is an interdisciplinary research project that envisions a technology allowing to store and transport information on the nanometer length scale and at operational frequencies in the THz regime. Such a technology will be realized through an optical manipulation of hybrid molecular/antiferromagnetic interfaces, which will enable a selective activation of information emitters and detectors. Such a selectivity will be ensured by the local nature of the hybridized electronic states that develops at the interface between an antiferromagnet (AF) and a molecular system. The main objective of SINFONIA is to exploit the hybridized states created at such interfaces to couple an external optical stimulus to the propagation of magnetic perturbations (namely spin waves) in the AF layer. This way, SINFONIA proposes a completely new approach to information technology, based on hybrid organic/inorganic low-dimensional systems. Among the breakthroughs offered by such a change of paradigm, there are: low power consumption (no electrical currents), high-frequency responses (ensured by AF materials), tunability (ensured by molecular materials), scalability and miniaturization, on account of the intrinsic low-dimensionality of our interface-based approach. SINFONIA also envisions the long-term perspective of realizing fully organic devices, thurough the development of organic AF films. The proof-of-concept of the proposed technological approach will be sought in the development of magnonics prototypical devices, such as logic gates. Magnonics is widely recognised as one of the most promising technological approaches to go beyond CMOS technology, which represents the state-of-the-art in information and communication technology.

Keywords: information technology,hybrid organic inorganic interfaces,nanotechnology,antiferromagnets,magnonics
Protection of Critical Infrastructures from advanced combined cyber and physical threats (PRAETORIAN)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Protect and improve the resilience of critical infrastructures, supply chains and tranport modes
Action type: Innovation actions
Countries involved: Austria,Spain,Germany,Spain,Austria,Austria,Germany,Croatia,Belgium,Croatia,Greece,France,France,France,France
Call: Prevention, detection, response and mitigation of combined physical and cyber threats to critical infrastructure in Europe (H2020-SU-INFRA-2020, 2020)
Start date: 2021-06-01
End date: 2023-09-30
Duration (months): 28.0
Total project cost (EUR): 9037987.5
EU funding (EUR): 7580898.0
Participants: 25
Project status: SIGNED

PRAETORIAN strategic goal is to increase the security and resilience of European CIs, facilitating the coordinated protection of interrelated CI against combined physical and cyber threats. To that end, the project will provide a multidimensional (economical, technological, policy, societal) yet installation-specific toolset comprising: (i) a Physical Situation Awareness system, (ii) a Cyber Situation Awareness system; (iii) a Hybrid Situation Awareness system, which will include digital twins of the infrastructure under protection; and (iv) a Coordinated Response system. The PRAETORIAN toolset will support the security managers of Critical Infrastructures (CI) in their decision making to anticipate and withstand potential cyber, physical or combined security threats to their own infrastructures and other interrelated CIs that could have a severe impact on their performance and/or the security of the population in their vicinity. The project will specifically tackle (i.e. prevent, detect, response and, in case of a declared attack, mitigate) human-made cyber and physical attacks or natural disasters affecting CIs. It will also address how an attack or incident in a specific CI can jeopardise the normal operation of other neighbouring/interrelated CIs, and how to make all of them more resilient, by predicting cascading effects and proposing a unified response among CIs and assisting First Responder teams. PRAETORIAN is a CI-led, user-driven project, which will demonstrate its results in three international pilot clusters –some of them cross border– involving 9 outstanding critical infrastructures: 2 international airports, 2 ports, 3 hospitals and 2 power plants.

Keywords: situation awareness,cascading effects,critical infrastructure,first responder,digital twin,combined physical and cyber threats,resilience,natural disaster,man made incident,coordinated attack
Multi-modal interrogation of instinctive behaviours and intrahypothalamic connectivity (DRIVOME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Mammalian behaviour is driven by instincts such as hunger, sex and aggression which are familiar to everyone from daily experience. Anomalies in these instincts cause disorders such as anorexia, excessive sexual drive and episodic dyscontrol syndrome, and potentially also psychologically difficult situations like marital infidelity. Neuronal circuits that drive these instincts reside in the hypothalamus where research is gaining pace rapidly. Recent work has uncovered hypothalamic neuronal populations in mouse, that can drive the following fundamental mammalian behaviours: feeding (Aponte et al., 2011, Betley et al., 2015), sex/aggression (Lee et al., 2014, Lin et al., 2011), sleep/wakefulness (Adamantidis et al., 2007, Jego et al., 2013) and parental behaviours (Marlin et al., 2015, Wu et al., 2014). Older work has demonstrated similar effects with cruder manipulations of the hypothalamus in several species. Classical work in ethology (Lorenz, 1981, Tinbergen, 1951) as well as newer anatomical insights (Swanson, 2000) have outlined hypotheses for how neuronal network architecture may guide the organization of instinctive behaviours into the coherent, adaptive, context-relevant displays evident throughout the animal kingdom. Modern techniques (opsins, genetically encoded calcium indicators, transgenic mice, multi photon imaging of deep brain structures and optrode recording) are now ripe for comprehensive cell-type specific probing of the hypothalamic networks in charge of fundamental drives and possibly emotions. We propose to use these methods to elucidate the intrahypothalamic wiring diagram (the connectome of drives, or 'DRIVOME') that can explain how instincts are orchestrated.

Keywords: brain,hypothalamus,instinct,transgenic mice,patch clamp,optogenetics,in vivo recordings
Robotized Orbital Drilling Equipment and Optimized residual stresses (RODEO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France,France,France
Call: Orbital Drilling of small (<10mm diameter) holes, standardly spaced with aluminium material in the stack (H2020-CS2-CFP03-2016-01, 2016)
Start date: 2017-02-01
End date: 2020-01-31
Duration (months): 36.0
Total project cost (EUR): 499998.75
EU funding (EUR): 499998.75
Participants: 6
Project status: CLOSED

The main objective of the RODEO project is to propose a lightweight robotized orbital drilling equipment, and associated operating conditions and tools, to enable the drilling of tightly spaced small diameter holes in aluminium with the control of induced residual stresses. This will be accomplished by: - modelling the phenomena involved in orbital drilling that impact residual stresses - developing a combined drilling and burnishing tool and associated operating conditions to attain required residual stresses - pursuing the development of a high-speed orbital drilling unit (existing in the consortium) capable to drive the tool in the prescribed conditions - integrating the developed orbital drilling unit on a lightweight industrial robot - defining the operating conditions of the lightweight robot to be used to ensure the drilling operation To reach this objective, numerical simulation tools (already developed in the consortium) will be used to pursue the study and determine the mechanisms modifying the properties of the material during orbital drilling, and the impact on fatigue life (including the influence of a fastener). As a result, solutions to increase residual stresses in aluminium holes will be suggested in terms of cutting conditions, tool geometry and holemaking strategy (including burnishing). From this, an innovative orbital drilling tool, combining cutting and burnishing active parts will be developed and associated operating conditions will be proposed. To drive this tool along the expected trajectory with the required speeds, the development of a high-speed orbital drilling unit (provided by PRECISE) will be pursued. This will require the adaptation of the equipment to allow burnishing, and the integration of monitoring devices for cutting forces, spindle speed, feed speeds measurements. The orbital drilling unit will be handled by a lightweight industrial robot that will permit to drill holes without the need of a drill jig, allowing the drilli

Keywords: innovative cutting tool,light orbital drilling spindle handled by a lightweight industrial robot,control of residual stress
Drones and Egnss for LOw aiRspacE urbAN mobility (DELOREAN)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling exploitation of space data
Action type: Innovation actions
Countries involved: Spain,Spain,Germany,Spain,Spain,Belgium
Call: EGNSS applications fostering green, safe and smart mobility (H2020-SPACE-EGNSS-2019, 2019)
Start date: 2019-12-01
End date: 2023-09-30
Duration (months): 46.0
Total project cost (EUR): 2448952.5
EU funding (EUR): 1805781.25
Participants: 8
Project status: SIGNED

As commercial aviation has been a major paradigm shift for the development of modern society, we are now facing a new leap in mobility services with the introduction of urban air mobility and urban air delivery. Our lives are now depending majorly on immediacy. From our everyday commute to work to the next-minute delivery on our preferred e-commerce platform, we are not good at waiting-in-line. And this has been mostly backed up by fast but robust technology breakthroughs enabling commercial aviation, satellite navigation and intelligent software. We are now facing a new technology breakthrough that will bring us even more immediacy. Urban Air Mobility (UAM) is finally a plausible reality that will bring multimodal fast commutes inside and around urban areas. Combining conventional means of transport with Urban Air Mobility is not only finally feasible, but it is the way to move forward in these very congested traffic areas. Furthermore, road delivery is congesting the streets of our cities and sub-urban areas for our everyday supplies. However, the urban sky is still unexplored, and as technology advances and regulatory frameworks develop further, Urban Air Delivery (UAD) services becomes a reality that could provide not only faster, but cleaner, delivery services, thus leaving the streets for the, still utopic, recreational cycle and walk arounds. This project will have two main pillars of research, development and operational implementation for Urban Air Mobility and Urban Air Delivery. The two pillars will provide the individual assets towards the main objective of the project: To develop the navigation and positioning requirements for the challenging urban air services, and demonstrate how EGNSS stands as an enabler of this future city sky.

Keywords: drones,urban air mobility,urban air delivery,egnss,sora
The neuroscience of tickling: cerebellar mechanisms and sensory prediction (NeuroTick)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,United States,United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2022-08-31
Duration (months): 36.0
Total project cost (EUR): 246669.61
EU funding (EUR): 246669.12
Participants: 3
Project status: CLOSED

Detecting surprising events, such as the sudden approach of a predator or an unexpected touch, is crucial for the survival of all species. We aim to study neuronal mechanisms underlying surprising events. In order to predict upcoming events, mental models of future actions are essential. Where in the brain are such predictions and mental models created? The somatosensory cortex might contain a body model, in which superficial layers provide context and sensory memories, and inputs from deeper layers allow for simulating body movements. In rats, the somatosensory cortex is activated by tickling, which is a special form of unexpected touch containing elements of both sensory and social surprise. However, self-touch induces signals which prevent activation of the somatosensory cortex and prevent self-tickle. Where do these self-touch induced inhibitory signals come from? We hypothesize that the cerebellum is the source of self-touch induced signals. The cerebellum has reciprocal connections with key forebrain areas, including the somatosensory cortex. Combined with its known role in adapting action to sensory and internally generated events, the cerebellum seems well placed to aid in the processing of surprising events. We will test in mice and rats the hypothesis that the cerebellum plays a key role in processing unexpected events to modulate representations in somatosensory cortex. By combining the applicant’s experience in recordings from awake behaving mice, the expertise of the lab of Prof. Wang at Princeton University in cerebellar research with a focus on motor and non-motor function, and the expertise of the lab of Prof. Michael Häusser at University College London in naturalistic systems neuroscience, we are well placed to study the cerebellar signals for sensory prediction. This study can help us to understand how we make sense of the complex environment around us by combining different inputs to form predictions and signal unexpected events during surprising situations.

Keywords: tickling,cerebellum,somatosensory cortex,touch,surprise,systems neuroscience,naturalistic behaviour
SMEntorEGE (SMEntorEGE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Türkiye,Türkiye
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 75510.0
EU funding (EUR): 75510.0
Participants: 3
Project status: CLOSED

The objective of SMEntorEGE is to support the regional SMEs to enhance their innovation management skills by improving efficiency and effectiveness of innovation processes, thus contributing to smart growth.Two groups of SMEs are targeted for the services that will be given under the project. The first group involves the SMEs who are the beneficiaries of “Horizon2020's SME instrument” or other EU Funded Schemes such as FETOpen, FTI but who need technical support in innovation management to enhance successful exploitation of the project and its contribution to the companies’ growth. The second group consists of SMEs with potential for international growth via product/process/service/business model innovation but who lack the knowledge, skills to manage innovation activities. Two different services will be provided throughout the project period. “Key account management” for the beneficiaries of the SME instrument will focus on identifying bottlenecks to the creation of economic impact in companies benefitting from EU grants and address these bottlenecks with the help of capable Coaches and with the aid of KAM services of EEN. “Enhancing SME innovation management capacity” for innovating SME independently from a specific project will focus on increasing the efficiency and effectiveness of innovation processes in SMEs with significant innovation activities that could potentially become beneficiaries of European research and innovation supports, but not have effective access to consulting services for innovation management. As a result of the project, new types of standardised innovation support methodologies will be developed, the skills of the staff from the existing consortia will be improved, comprehensive innovation support will be given, two novel assessment tools will be adapted at EU level, EEN will be embedded in Regional Innovation Ecosystem, closer cooperation will be established between key innovation support providers and relevant stakeholder

Keywords: innovation management capacity,smes,mentoring,coaching,key account management
A Compact and Automated Liquid Handling Platform for Biomedical Assays (AutoLiqHand)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-01-01
End date: 2018-06-30
Duration (months): 18.0
Total project cost (EUR): 149750.0
EU funding (EUR): 149750.0
Participants: 1
Project status: CLOSED

Liquid handling is an integral part of biological and medical assays. For many applications the method of choice is manual pipetting, which has significant limitations. Chiefly, it is user-time intensive and prone to sample handling issues (poor time accuracy and pipetting errors). While liquid handling robots do exist, they are expensive instruments, shared by many users and targeted for high-throughput applications. This leaves, in practice, most research and diagnostics without an automated solution. Here, we present an innovative solution to this problem: a compact and mobile automated liquid handling (AutoLiqHand) device for the individual user. This platform will enable to automate biomedical experiments and diagnostic routines which are currently done by hand. Moreover, its unique design enables it to run in a much larger range of biomedical settings than currently offered by existing solutions, and at the fraction of the cost. This platform was developed as part of the ERC-funded project SelfOrg and is routinely used in our lab for a variety of specialized and standard routines (e.g. drug treatment and immunostaining). The AutoLiqHand system mimics the main advantages of manual pipetting, namely simplicity and versatility, through a unique design of a fully integrated and microfluidic-based platform. In addition, when interfaced with well-established biomedical equipment such as ELISA readers or PCR machines, our platform can form a fully automated lab at significantly lower costs than commercially available devices. Thus, it has the potential to become a standard tool for researchers both in basic and early pharmaceutical/clinical research as well as for clinicians in point-of-care diagnostics. The aim of this Proof-of-Concept proposal is to adapt the AutoLiqHand platform to market needs and optimize it for production in order to make it available to the market.

Keywords: liquid handling,automation,life science,biomedical diagnostics,point of care,biotechnology,cell biology,laboratory instrumentation,microfluidics