Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Adaptation to Recurring Fasting by Chromatin-Mediated Memory (MemoChrom)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Adaptation to recurring environmental challenges (food availability, seasonal rhythms etc.) is a mainstay of physiology. As such, mammals are exquisitely fitted to tolerate frequent bouts of fasting owing to hepatic production of fuels (glucose, ketones). Indeed, studies show significant health benefits of intermittent fasting. Due to the reliance of the fasting response on chromatin and transcriptional regulation, I hypothesize that mammals adapt to recurring fasting by sensitizing transcriptional programs and maximizing future responses, thereby increasing survival. I plan to uncover transcriptional mechanisms of ‘fasting memory’ that mediate the health benefits of recurrent fasting. I will profile the hepatic transcriptome and genome-wide chromatin landscape of intermittently-fasted mice to discover the mediators of such memory. I will evaluate three plausible mechanisms: (1) Enhancer priming whereby the DNA regulatory elements dictating gene expression are kept in a primed state between fasting episodes. (2) Promoter priming in which RNA polymerase is paused at gene bodies during feeding and rapidly released upon re-fasting. (3) Transcriptional cascades whereby genes induced in the previous fasting bout are active in the next one, directing a second wave of gene expression. The molecular mechanisms mediating memory will be examined in a series of gain/loss of function experiments targeting various components of transcriptional regulation (transcription factors, RNA polymerase, histone and DNA modifications etc.). Both the notion of fasting memory and the cellular mechanisms driving it are supported by preliminary results. The concept raised here has the potential to unravel a fundamental homeostatic response and significantly advance fasting research. More broadly, such a discovery would reshape our view of transcriptional regulation as a cellular adaptation mechanism to recurring challenges and of physiological habituation to the environment.

Keywords: fasting,chromatin,transcription,enhancers,transcription factors,liver,hepatology,metabolism
Genome-wide CRISPR/Cas9 screen in intestinal organoids for identification and molecular characterization of therapeutic targets to enhance tissue regeneration (ScrIntOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Around 3 million people in Europe are affected by inflammatory bowel disease (IBD), a devastating condition characterized by chronic inflammation of the digestive tract causing severe damage to the intestinal epithelium. Current medication strategies aim to relieve symptoms by reducing the inflammatory burden without promoting epithelial repair to restore tissue integrity. It is therefore of great importance to enhance the current understanding of intestinal regeneration and thus facilitate the development of novel pharmaceutical compounds to improve tissue recovery in IBD patients. However so far, only few regulators of intestinal regeneration with quite distinct cellular functions have been identified, suggesting an interplay of various molecular pathways that orchestrate intestinal repair. This therefore raises the question of which cellular and molecular mechanisms safeguard epithelial regeneration. To address this issue, I will combine a unique in vitro organoid system, developed in the host lab that captures epithelial cells in a regenerative state, with my expertise in large-scale screening approaches to: (1) perform an unbiased genome-wide CRISPR/Cas9 screen to identify novel regulators of intestinal regeneration, (2) validate essential pathways in intestinal repair in vitro and in vivo, and (3) dissect the molecular events coordinating tissue healing. The outcome of this project will on one hand provide a comprehensive list of factors and their molecular function controlling this cellular process and on the other hand uncover novel druggable pathways in IBD to enhance the regenerative capacity of the intestinal epithelium. Executing this MSCA fellowship proposal will equip me with expert knowledge in epithelial biology and associated pathologies, cutting-edge technologies and an essential set of transferable skills, which all together will ensure my successful establishment as an independent group leader in the field of regenerative stem cell biology.

Keywords: crispr,cas9 screen,organoids,intestinal regeneration,inflammatory bowel disease
Pheromones for ecologically friendly pest control in fruit orchards (EcoFruit) (EcoFRUIT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-12-27
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: CLOSED

The agriculture is under a pressing need for alternatives to insecticides for pest control. The ban of three neonicotinoids used as insecticides was settled in April 2018 by the European Union. At the same time, agricultural productivity needs to rise to provide sufficient nutritious food for a growing population. Moreover, a recent study predicts an increase in global yield losses of rice, maize and wheat by 10-25% per degree of global mean surface warming due to increased population growth and metabolic rates of insects. Pheromones, which are naturally produced by different insect species, represent a health- and environment-friendly alternative to insecticides. Dispensing small amounts of sex pheromones in the fields or orchards confuses males, prevents mating and hence larvae formation. This method is called “mating disruption”. Pheromones are attractive, because they are biodegradable, species-specific compounds, which neither harm beneficial species nor humans. Nevertheless, pheromones are still not widely used, mainly because of the high costs of synthetic pheromones, labor-intensive application of pheromone dispensers, and lack of knowledge on efficacy of pheromone release methods. Therefore, the goal of the project is the sustainable and cost-efficient production of insect pheromones by fermentation in engineered oleaginous yeasts. Moreover, this project will also research into efficacy of different methods for pheromone release. As a consequence, the hurdles for a widespread pheromone usage will be decreased. This would support the development of a long-term sustainable and efficient agricultural sector. Through a wide dissemination and educational campaign, we will raise the awareness of pheromones as pesticide alternatives among farmers, politicians and the general public.

Keywords: cell factories,bio based chemicals,pheromones,mating disruption,lepidoptera,synthetic biology,crop protection
Towards Game-changer Service Operation Vessels for Offshore Windfarms (NEXUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: Innovation actions
Countries involved: Spain,Norway,Norway,Belgium,Norway,France,United Kingdom,United Kingdom
Call: High value-added specialised vessel concepts enabling more efficient servicing of emerging coastal and offshore activities (H2020-BG-2017-1, 2017)
Start date: 2017-11-01
End date: 2021-04-30
Duration (months): 42.0
Total project cost (EUR): 4248589.99
EU funding (EUR): 3337098.88
Participants: 9
Project status: CLOSED

NEXUS will develop and demonstrate novel, beyond state of the art, specialised vessel and logistics for safe and sustainable servicing of offshore wind farms. NEXUS includes: simulation, model testing, consideration of the most suitable construction and production principles for small series or one off vessels of this type. Key aspects of NEXUS include environmental impact assessment, cost estimation as well as both the marketability (technology push), and the cost effectiveness of the offshore operations concerned (demand pull). The project will develop the concepts and validate on a demonstrator at a technology readiness level (TRL) 5 with the overall aim to reduce the marine logistics cost of offshore wind turbine maintenance by 20% compared to current practices. In addition NEXUS will enable the increase the professional skills of workers and the capability of European industry and in particular SMEs within the marine and maritime sectors to develop and commercialise specialised vessels and related technology, and will support European growth and employment through development of a blue economy.
Developing and Implementing hands-on training on Open Science and Open Innovation for Early Career Researchers (DIOSI)

Framework: Horizon 2020 — Science with and for Society
Programme: Make scientific and technological careers attractive to young students, and forster sustainable interaction between schools, research institutions, industry and civil society organisations
Action type: Coordination and support actions
Countries involved: Germany,Spain,Italy,Cyprus,Finland,Croatia,Poland,Switzerland,Belgium,Netherlands,United Kingdom
Call: Research innovation needs & skills training in PhD programmes (H2020-SwafS-2020-1, 2020)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 299188.75
EU funding (EUR): 299188.75
Participants: 13
Project status: SIGNED

The DIOSI project proposes a full cycle concept on doctoral education, from the development of a new joint doctoral educational programme, through the provision of training on Open Science and Open Innovation & Entrepreneurship for doctoral candidates and early career researchers (DCs and ECRs), to the measurement of impact of such training, by creating an impact and graduate tracking framework. First, in order to integrate skills training into PhD programmes and to value training in transferable skills as equitable to research skills, we develop a DIOSI model for doctoral education. Second, in order to tackle skills shortages in terms of innovation and entrepreneurship skills of researchers and the need for a culture shift towards Open Science, we will provide training on Open Innovation & Entrepreneurship and Open Science for DCs and ECRs. The project will fund train-the-trainer sessions to build capacity and expertise and take the existing offers to the next level. Each newly formed trainer will then run a pilot session at the home institution. During the project, up to 900 DCs and ECRs will benefit from the training. Third, in order to understand the impact of such training, we implement a joint impact and graduate tracking framework. The DIOSI partners have strong collaboration ties, as they are the YUFE universities (Young Universities for the Future of Europe European University Alliance). Therefore, the institutions have committed to co-fund each of the work packages and apply for this funding to boost their DCs and ECRs skills training and future careers!

Keywords: doctoral training,transferable skills,entrepreneurship,innovation,open science,graduate tracking
Fellowships in Advanced Cultural and Social Studies at the Max-Weber-Kolleg (MWK-Fellows)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Fellowship programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Germany
Call: Marie Skłodowska-Curie Co-funding of regional, national and international programmes (COFUND-FP) (H2020-MSCA-COFUND-2014, 2014)
Start date: 2015-09-01
End date: 2020-08-31
Duration (months): 60.0
Total project cost (EUR): 2832000.0
EU funding (EUR): 1416000.0
Participants: 1
Project status: CLOSED

The MWK-Fellows programme financed by COFUND aims to allow excellent incoming researchers from countries other than Germany (in accordance with the EU-mobility-rule) to conduct their own, freely chosen, independent research projects in a highly competitive and intellectually vibrant research environment provided by the Max Weber Center for Advanced Cultural and Social Studies (Max-Weber-Kolleg). The Max-Weber-Kolleg is a high-ranking research centre which forms an avant-garde institution of the University of Erfurt. It is distinguished by a unique organisational structure – combining the features of an Institute for Advanced Study and a Graduate School – and a ‘Weberian’ research programme. The ‘Weberian’ research programme combines historical, comparative and interdisciplinary perspectives with an interest in normative issues in the social sciences. It has a focus on societal challenges of contemporary societies, especially (religious) plurality, cultural diversity and social order, processes of acceleration and growth. The core disciplines are sociology, economics, religious studies, law, philosophy and history, but MWK-Fellows programm is open for related areas as well. The Max-Weber-Kolleg is based on the principles of interdisciplinarity and internationality with a long-standing and progressively fine-tuned fellowship programme. By means of the COFUND-action Max-Weber-Kolleg will not only increase the number of international fellows but include a new intersectoral dimension into its fellowship programme. At the Max-Weber-Kolleg, MWK-Fellows will enjoy the best possible support and an opportunity of being connected with larger research projects. Nevertheless the applicants’ freedom of choice of the research project is fully guaranteed. The MWK-Fellows programme will improve international high-level research and science with and for society and will contribute to the fostering of the European Research Area (ERA), especially in the field of societal challenges.

Keywords: advanced cultural and social studies,interdisciplinarity,internationality,intersectorality
Hook a Worm to Catch a Man: Tracking Historical and Recent Human Settlement, Land use and Migration in Neotropical Rainforests using Ecosystem Engineers (HOOKaWORM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom,Brazil
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 36.0
Total project cost (EUR): 261599.4
EU funding (EUR): 261599.4
Participants: 2
Project status: CLOSED

The anthropologic and archaeological study of pre-Columbian people of the Amazonian basin has revealed sophisticated agriculture practices. Notwithstanding the absence of historical written records the biological evidence of these practices remains in the remarkable biodiversity of the Amazonian 'dark earths' (ADEs) or “Terra Preta do Indio” produced by ancient civilisations to promote highly productive and sustainable agriculture. Promoting the interdisciplinary connection between anthropology, soil ecology and genomics the applicant will be able to investigate both the relationship of ADEs to the associated extant biodiversity, reveal details of past and current anthropogenic impact on the natural surroundings, as well as new clues regarding settlement dynamics over a large part of Brazil. The applicant and the supporting team will accomplish this by: a) Assessing the current soil biodiversity assemblages to gain knowledge about the functioning and potential role of soil ecosystem engineers, organic matter and nutrients to the formation of these extremely fertile soils; this novel approach will aid in understanding the origin and sustainable management of ADEs as well as highly weathered and acid soils under humid tropical conditions. b) Using DNA barcoding to describe the diversity of the ecosystem engineer community associated with past and recent Amerindian settlements throughout the Amazonian basin. c) Using genomics of a peregrine species closely related with human landscape domestication to mirror the human exchanges and flow among the Neotropical rainforest associated with the migration of Amazonian Indians. This will be achieved by integrating the state-of-the-art methods in invertebrate morphology, molecular genetics, and computational analyses with incorporation of pre-existent and new ecological, anthropological and environmental metadata sustained by a multidisciplinary collaborative network.

Keywords: ecosystem engineers,genomics,human migration,amazon dark earths,soil fertility
Transforming the enterprise software industry: CloudStorm open source enterprise application development and integration framework (CLOUDSTORM)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Hungary
Call: New business models for inclusive, innovative and reflective societies (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-11-01
End date: 2017-04-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Nearly €550 billion is spent globally on enterprise software each year. Few large framework providers (e.g. SAP, Microsoft, IBM) heavily dominate the industry, and yet, their approach to software development is obsolete in the light of modern application development. Hence enterprises looking to implement new software can either buy bulky, unfocused software packages that excel in nothing, or buy focused applications from unknown vendors and risk an integration nightmare. We are proposing a solution for 600 000+ IT companies in Europe that breaks down the technical and financial barriers for them to enter enterprise software industry. Our solution is CloudStorm framework: the first open source enterprise software development and integration framework that effectively capitalizes upon synergies between established enterprise IT infrastructures (e.g. SAP) and the best practices from modern web and mobile application development. CloudStorm enables IT companies of all sizes and scopes to build and deploy highly competitive, built-for-purpose enterprise applications at least 2 times quicker and with at least 10 times lower final price compared to the currently leading vendors. We were recently awarded a Amazon Web Services grant, as they see a game changing potential in our ambition to bring business model innovation to the closed-up enterprise software industry. By combining open source ideology with premium features, we expect to reach €420 million revenue by 2023. The objective of CLOUDSTORM feasibility study is to prepare for final development and commercial launch of the next generation CloudStorm framework and its complementary premium services. Phase 1 will focus on a detailed business plan creation, IPR study, and technical testing activities. We are planning to define the product roadmap during the feasibility study and continue its implementation in Phase 2 project.

Keywords: business model innovation,enterprise software,open source,software development framework
New Rotor Blade Design for Wind Turbines (Triblade)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Sweden,Sweden
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-09-01
End date: 2016-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Much of the challenge for wind energy investors is that wind turbine technology is a capital-intensive industry. The capital costs of a wind power project can be broken down into several categories, where 13% is attributable to rotor blades, which become decisive in reducing costs. In order to increase the efficiency further, and to extract more energy, the trend is to make the turbines larger. However, as the length of current rotor blades increase, their associated cost and weight increase at a faster rate than the turbine’s potential power output, not being economically viable to produce turbines beyond a certain size. Furthermore, as blades get longer they are becoming increasingly difficult to manufacture and transport. In sum, the technical and commercial performance of wind turbines is currently limited by the rotor blade technology and to overcome this problem new design approaches and/or new materials and standardisation of production processes are needed. Leveraging on this market opportunity, Winfoor (WF) and Marstrom Composite (MC) are partnering to develop and introduce a new and ground-breaking technology to the wind energy market. The novel technology, Triblade, is a “3-in-1 blade” that will allow rotor blades to double current size and to reduce 80% weight, whilst reducing around 70% production costs and increasing ease of transport and installation. Commercialisation of Triblade will allow global wind manufacturers to produce larger and more efficient turbines, with simpler installation process and shorter time to market. The companies hold complementary skills, expertise and roles required to market this unique technology, being well positioned to guide Triblade to a sustained market entry and ceasing a market opportunity for an accumulated turnover of approx. €87 million in a period of 5 years.

Keywords: wind energy,new blade design,triblade