Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Expanding the chemical biology toolkit for the studies of histone post-translational modifications (PTMs) (CHEMBIOHISTONE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Studying biomolecules in living cells is an important step towards understanding the cause and development of diseases. However, the existing tools dedicated to the study of biomolecules often lack generality and pose disturbance to the biological systems. Although bioorthogonal chemistry plays an important role in biomolecule studies, there are only a handful of bioorthogonal reactions that can modify these molecules in vivo. In this project, we will develop a novel biocompatible reaction that can be widely used for modifying biomolecules both in vitro and in vivo. We will then employ the reaction to reveal the biological significance of post-translational modifications (PTMs) of histones proteins by using two strategies. First, the histone mimics that are not accessible by the existing methods will be synthesized. These histone mimics can serve as important models for us to understand the interactions between histones and their regulating enzymes. Second, real-time imaging of histone PTMs in living cells will be made possible by using a chemical biology approach. This approach can minimize the disturbance to the three-dimensional structure of the nucleosome, thereby providing a true image of dynamic histone PTMs during cellular processes. In short, this multidisciplinary project lies on the interface of organic chemistry, biochemistry, and cell biology, with an aim to enable the in-depth studies of the unknown aspect of epigenetics.

Keywords: chemical biology,protein chemistry,post translational modification,free radical reaction
A therapeutic vaccine candidate for lung cancer based on an exclusive cell line of Plasmacytoid Dendritic Cells (PDC*line) (PDClungSME1)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: France
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2017-02-28
Duration (months): 7.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Since 2014, the revolution of immuno-oncology gives unprecedented hope for cure to cancer patients thanks to immunotherapies such as anti-PD(L)-1. However around 80% patients still don’t respond to anti-PD(L)-1. Several barriers are still to be overcome to sustain the path of a novel paradigm responding both unmet therapeutic needs and health economy sustainability; cancer being estimated as a leading cause of deaths in Europe (350’000 deaths in 2012– Globocan) corresponding to an economical burden of €126BN in total costs PDC*line Pharma develops a ground-breaking therapeutic vaccine platform using an exclusive cell line of Plasmacytoid Dendritic Cells (PDC*line); potentially doubling the response rate to anti-PD(L)-1 without additional toxicity, eliminating complex and costly process usually required by cell therapies. Our innovation project is aiming to establish the clinical proof of concept that PDC*lung, our leading candidate for lung cancer can induce strong anti-tumour immunity in patients. Lung cancer is of high priority for Europe since 1.9 million people are affected worldwide of which 340 000 in Europe (Globocan, 2012). It also represents an attractive market segment opportunity for PDC*line Pharma with an expected market growth of 4% per year: $6.1BN in 2013 to $8.6BN in 2023 worldwide (IMS, 2015).

Keywords: immuno oncology,therapeutic cancer vaccines,cell therapy,plasmacytoid dendritic cells,allogeneic,lung cancer
Online and unbiased skills assessment for a smarter hiring process (SmartHire)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Denmark
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-06-01
End date: 2018-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

SmartHire will mature, demonstrate and scale-up the PeerPilot platform, a talent assessment system to support talent acquisition in enterprises and public institutions worldwide, which are presently looking to shorten their recruiting process, bring down the cost of said process and at the same time secure top talent and a good candidate job fit. However, these needs are scarcely met by the available solutions in the marketplace. PeerPilot aims to accommodate these needs by introducing a scalable, automated, highly customizable, efficient and cost competitive solution. PeerPilot is a SaaS platform, which conducts online case-competitions. These can be pre-defined or customized for each client. The case competition includes 4 phases: Briefing (introduction to case), brainstorming (building ideas with the other participants), solution building (co-creating solutions with other candidates) and evaluation (of the candidates). The evaluation phase evaluates the candidates based on 3 key variables: Impact (on the results), engagement (with the other participants) and collaboration (with the other participants). Then a comprehensive and highly customizable evaluation report is produced to support the manager in the further recruiting process. PeerPilot is currently in beta version, but has been used in several trials having delivered excellent results. PeerPilot Aps plans to commercialize the platform via direct and partner sales to the customers via a hybrid Saas licensing model. The solution is relevant to any hiring employer of medium to large size worldwide and the long-term plan is thus to commercialize PeerPilot globally. The SmartHire project will support the company in this endeavor by clarifying technical, legal and cultural challenges in the feasibility report. Five years after the innovation project, we expect accumulated revenues and profits of EUR 51 and EUR 35 million respectively and to employ 67 employees.

Keywords: talent acquisition,recruiting process,online case competition platform,advanced analytics
Refugee Emergency: DEFining and Implementing Novel Evidence-based psychosocial interventions (RE-DEFINE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Italy,Türkiye,Finland,Switzerland,Netherlands,Denmark,United Kingdom,United Kingdom
Call: Global Alliance for Chronic Diseases (GACD) prevention and management of mental disorders (H2020-SC1-2017-Single-Stage-RTD, 2017)
Start date: 2018-01-01
End date: 2020-12-31
Duration (months): 36.0
Total project cost (EUR): 2915511.47
EU funding (EUR): 2915511.4699999997
Participants: 11
Project status: SIGNED

RE-DEFINE aims to implement effective psychological interventions for preventing the onset of mental disorders in refugees and asylum seekers with psychological distress resettled in middle-income and high-income countries. RE-DEFINE is particularly relevant for the refugee crisis in Europe and in bordering countries (i.e., Turkey), as the progressive increase in refugees seeking asylum poses a significant challenge to the health systems’ capacity to adequately respond to the health needs of this population. The project focuses on adaptation, testing, and implementation of Self Help Plus (SH+), a novel trans-diagnostic self-help preventive psychosocial intervention specifically developed by the World Health Organization (WHO) to respond to humanitarian crises. The intervention will be delivered by non-specialists to groups of up to 30 participants at a time. The cost-effectiveness of SH+ will be tested in two large, multicentre, pragmatic randomised studies. One study will be conducted in Italy, Germany, Finland, Austria, and the UK (high-income countries), and a second study will be conducted in Turkey (middle-income country). The dissemination plan will include structured activities such as an Individual Participant Data (IPD) meta-analysis of all randomised data available on SH+, in order to identify specific predictors of intervention’s effects that will facilitate its uptake and long-term implementation in European and non-European countries.

Keywords: evidence based intervention,prevention,randomised controlled trial,implementation
Transferring hydrological and biogeochemical concepts from boreal to Mediterranean RIPARian zones: developing a broad knowledge framework across ecoregIONS (RIPARIONS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 160932.77
EU funding (EUR): 160932.48
Participants: 2
Project status: CLOSED

Science-based, sustainable management is needed to preserve the diverse and essential services provided by freshwaters. In natural and semi-natural areas, up to 90% of the total river length is in headwaters (i.e. small streams). Water quality in these “lungs of the landscape” is controlled primarily by soils adjacent to streams, i.e. riparian zones (RZs). Within RZs, the dominant source layer (DSL), a localized hotspot, contributes most of the solute and water fluxes to streams. However, the relative importance of DSL hydrological and biogeochemical processes controlling freshwater quality varies across ecoregions. The overall aim of RIPARIONS is to develop a unified knowledge framework based on DSL hydrological and biogeochemical functions across Europe to predict material transfer from soils to surface waters and consequent effects on water quality. Specifically, RIPARIONS will extend the DSL conceptual model developed in the boreal ecoregion by testing its applicability in two contrasting (sub-humid and a semi-arid) Mediterranean catchments. First, DSLs will be identified via hydrological site characterization using digital elevation models and on-site measurements. Biogeochemical investigations will link DSL processes and stream solute processing to assess stream water quality. Modelling of climate change impacts on DSL position and subsequent effects on future water quality will be assessed. Finally, a synthesis and integration of this work with previous and ongoing work in boreal and temperate sites will create a unified framework predicting RZ function and water quality across European ecoregions based on the DSL concept. While the Water Framework Directive mandates protection of RZs to maintain ecological status of rivers, it does not state how to manage them. RIPARIONS will fill this gap by identifying hotspots of water movement/processing within RZs (i.e. DSLs) that are the most influential for freshwater chemistry, and thus the most in need of protection

Keywords: riparian zone,catchment,carbon cycle,water quality,forest management
Smart, flexible, decentralized water treatment (M-NBS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-06-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Although in EU countries, the access to sanitation is universal in urban areas, Eastern Europe, the Caucasus and Central Asia (EECCA), all belonging to the European WHO Region, lack adequate access to water services. Indeed, more than 4.3 million people still rely on surface water as their primary source, posing severe risks to health. 90% of people using surface water live in rural locations. The main reason of this inequality is of economic nature. Given the low economic capacity of the mentioned areas in public infrastructure, the investments in water services are addressed at the highly populated areas. Ayala is a SME company with 8 employees whose mission is to bring the knowledge in the field of phytoremediation to an operative level by creating tools to restore balance to the environment employing natural mechanisms without consuming energy. With this goal, we aim to developed a modular Natural Biological System™ (M-NBS), a sustainable natural technology for treating sewage and waste streams, rehabilitating affected water bodies and rebalancing watersheds. The system, which has been successfully applied NBS in more than 100 large scale natural sanitation and remediation projects as non-mobile unit, is based on a proprietary phytoremediation technology capable to treat 7 to 70 m3 water/day per cubic meter of the system depending on the water pollution level. Our goal is to achieve a market penetration for M-NBS in Eastern European and neighboring countries so that we manage to service 5 % of 62 million people in the region without access to sanitation Europe in the next 5 years.

Keywords: portable,natural biological system,sanitation,water treatment
Antimicrobial Integrated Methodologies for orthopaedic applications (AIMed)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Ireland,Italy,Germany,Spain,Bulgaria,Croatia,France,France,Portugal,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 3845532.12
EU funding (EUR): 3845532.12
Participants: 12
Project status: SIGNED

The AIMed network, consisting of 12 beneficiaries and 6 partner organisations, will develop a range of materials with anti-bacterial properties that are suitable for use on the surfaces of orthopaedic implants. This is in response to the increasing problem of post-operative infection by antibiotic-resistant bacteria. By combining several approaches to disrupt surface biofilm formation, the materials developed by the AIMed network will eventually result in fewer surgical infections, faster recovery of patients, and greatly reduced post-operative healthcare costs. The network will develop novel peptide sequences and ways of binding them to the surfaces of olymers, ceramics and metals. A complementary approach will be the developent of metal ion substituted calcium phosphate coatings which can be applied to implants by additive manufacturing techniques. The efficacy of these anti-bacterial surfaces will be further enhanced by laser processing of the material to make it unattractive to biofilms (by altering the roughness and wetting characteristics). The network will carry out a thorough investigation of the properties of the new materials to ensure that they are feasible for use in future implants. This work will include the evaluation of antibacterial action and biocompatibility using appropriate models. Training of the 15 ESR's appointed to the network will be multi-disciplinary and intersectoral, with an emphasis on the need for technology transfer from academic institutions to commercial users.

Keywords: antimicrobial peptides,surface modification,ceramics,polymers,metal alloys,polypeptides,medical device
Novel strategies for anti-HIV-1 therapy: Small molecules targeting RNA partners of the nucleocapsid protein (BICEPSvsHIV)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-01
End date: 2019-06-30
Duration (months): 24.0
Total project cost (EUR): 164203.8
EU funding (EUR): 164203.8
Participants: 2
Project status: CLOSED

European Commission considers HIV/AIDS as a top priority and significantly invests in research devoted to the development of alternative therapeutic strategies leading to new antiretrovirals, which are urgently needed to overcome the emergence of resistance to existing drugs. The “BICEPSvsHIV” project proposes a novel and innovative strategy that draws the spotlight on RNA. Specific RNA sequences of the viral genome are substrates of the HIV-1 nucleocapsid (NC), a highly conserved protein known for promoting remodeling of nucleic acid structures in essential steps of the virus replication cycle. The proposed strategy consists in the employment of bis-3-chloropiperidines (BICEPS) as RNA cross-linking agents able to freeze selectively the tridimensional conformations of the RNA partners of NC, thus impairing its activities. RNA is a challenging molecule from the medicinal chemistry perspective, but the rewards it can yield are invaluable. The Experienced Researcher (ER) will work at The RNA Institute (SUNY Albany) during the outgoing phase, aimed at 1) the elucidation of BICEPS detailed molecular mechanism of reaction towards RNA and 2) the identification of BICEPS targeting selectively the RNA substrates of NC. During the incoming phase at the University of Padova (UNIPD), the achievements will be translated into 3) the thorough biological evaluation of the in vitro NC inhibition by BICEPS, leading to 4) the identification of anti-NC lead compounds. The project provides the ER with an outstanding training-through-research opportunity by means of a personalized multidisciplinary project, in which the ER will enlarge her scientific profile with new excellent skills. The training includes both scientific and transferable skills, aimed at the reinforcement of the ER professional maturity and independence and at the establishment of long-term international collaborations.

Keywords: hiv 1 nucleocapsid protein,drug development,antivirals,rna cross linking,rna protein complexes,nucleic acids mass spectrometry
Thermally stable nonporous gold for improved automotive catalytic converters (np-Gold)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Israel
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2020-12-01
End date: 2022-11-30
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

70% of the toxic gasses emitted from automotive exhaust systems originates from the first 60 seconds of the cold start. Severe health effects are associated with air pollution from motor vehicles. In fact, it causes 6% of total mortality per annum, half of which is attributed to vehicle emissions. Current catalytic converter technology relies on expensive platinum group metals (Pt, Pd, Rh) which are very effective in oxidizing these toxic gases at elevated engine working temperatures, however, they completely fail to catalytically convert the gases at temperatures of cold starts. Nanoparticles of gold are well known for their superior catalytic capabilities at low temperatures. Nevertheless, they have never been integrated into the catalytic converter technologies because of their tendency to coarsen at elevated temperatures and lose their catalytic activity. We have developed nanoporous gold (np-Gold) that has the same catalytic activity as that of gold nanoparticles but is thermally stable at elevated temperatures. This is due to the fact, that we form our np-Gold from a eutectic Au-Ge alloy and in the form of single crystals. The elimination of grain boundaries as well as more energetically stable facets of np-Gold removes the rapid diffusion routes leading to the coarsening of the nanoporosity and renders np-Gold thermal stability. This makes our np-Gold a promising candidate to solve the current problem of cold start catalysis. We trust that our np-Gold solution will make a great positive impact on the environment and society by lowering the levels of air pollution and occurrence of diseases attributed to toxic cold start vehicle emissions. We propose herein to study how we can incorporate our np-Gold into current catalytic converter products by replacing some of the current catalysts or incorporating as an add-on component to the existing technology.

Keywords: nanoporous gold,catalysis,bio inspired