Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Targeting the circadian clock in personalized disease prevention (CLOCKrisk)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Austria,United States
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2499965.75
EU funding (EUR): 2499965.75
Participants: 2
Project status: SIGNED

Virtually every cell of our body follows the 24-hr ‘circadian’ rhythm of a hypothalamic master pacemaker that evolved in the natural light-dark cycle. Decoding this circadian clock culminated in the Nobel Prize in Physiology or Medicine 2017 for the discovery of molecular mechanisms controlling the circadian rhythm. It is now recognized that a strong, unperturbed circadian clock is a hallmark of healthy aging. The introduction of electric light, however, presents unique challenges: today, 20% of the global work force engages in alternate working hours associated with light in unnatural times. Increases in the risk of major chronic disease and mortality have been associated with night work. Further, night-activity is widespread also outside of work, implicating potential risk for many. This project targets the urgency of alleviating adverse health consequences of a perturbed clock. It does so by aiming to decipher individual risk and related mechanisms 1) using a cutting-edge multi-polygenic score approach; 2) employing transgenerational, deeply phenotyped cohort approaches; and 3) carrying out interventions using genetic risk stratification. This epidemiological project builds on pioneering work of the applicant who conducted the first prospective study to demonstrate significant health effects of chronic clock dysregulation, leading WHO to classify night work as a probable carcinogen. Using transdisciplinary approaches, she implemented field and genetic studies and developed circadian biomarkers, establishing the field circadian epidemiology. Tying the transformative body of her work together, she proposes to take the next ground-breaking leap: To 1) identify the night-active individual who develops disease, 2) profile mechanisms involved, and 3) optimize effectiveness of interventions to improve sleep and shift work disorder, facilitating immediate implementation of risk-based prevention strategies aimed at promoting healthy aging in spite of clock perturbations.
Mechanism of protein kinases in biomolecular condensates (KinCond)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

Protein phosphorylation, mediated by kinases, plays a pivotal role in cellular regulation, with kinase dysregulation strongly associated with diseases like cancer, inflammation, and neurodegenerative disorders. Alzheimer's disease (AD) represents a significant global health challenge as the population ages at an accelerating pace. A key pathological feature of AD is the accumulation of hyperphosphorylated Tau, which disrupts normal neuronal function. Emerging evidence suggests that Tau undergoes liquid-liquid phase separation (LLPS), potentially linking AD and biomolecular condensation. Moreover, recent findings propose that LLPS intricately manages kinase signalling, creating condensed-phase structures (biomolecular condensates) that serve as recognizable sites for kinases. However, molecular mechanisms governing kinase behaviour within condensates are poorly understood. The central hypothesis of KinCond project is that the conformational landscape of protein kinases undergoes significant remodelling within biomolecular condensates, controlling substrate selectivity and specificity. This project focuses on the microtubule affinity-regulating kinase MARK2, a central player in the abnormal phosphorylation of Tau. KinCond is meticulously structured into three work packages: (1) investigating the specificity and reaction kinetics of MARK2 within Tau condensates, (2) deciphering the conformational landscape of MARK2 through advanced nuclear magnetic resonance methods and molecular dynamics simulations and (3) analyse the effect of biomolecular condensation on the conformational landscape of MARK2. The outcomes of KinCond are expected to provide crucial insights into the behaviour of protein kinases within biomolecular condensates, shedding much-needed light on the mechanisms of Tau phosphorylation in AD. Furthermore, the atomic-detail information obtained has the potential to open new avenues for the development of enhanced drugs targeting protein kinases.

Keywords: tau,alzheimer s disease,phosphorylation,biomolecular condensates,protein dynamics
Super-resolution magnetic correlation microscope (QMAG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Israel
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-07-01
End date: 2029-06-30
Duration (months): 60.0
Total project cost (EUR): 2565578.0
EU funding (EUR): 2565578.0
Participants: 1
Project status: SIGNED

Over the past several decades, the microelectronics industry has revolutionized nearly every aspect of our lives. The ever-growing need for faster and more efficient devices, recently emphasized by the extreme computing requirements of artificial intelligence techniques, is pushing traditional device architectures to their limits, prompting the search for novel physical realization of such devices. Currently, the most promising approach involves magnetic materials, as can be witnessed through the recent advent of magnetic memories as well as development of logic devices based on hybrid electronic/magnetic structures and the flow of magnetic charge, referred to as “spintronics”. Despite the tremendous progress achieved, the field of spintronics is held back by both fundamental and practical open questions related to issues such as magnetization switching and excitation dynamics, effects of magnetic and topological defects, and local conductance properties of magnetic devices. A major obstacle encountered in addressing these important open questions stems from limited measurement and characterization techniques – high-resolution sensing of dynamic response and conductance cannot be achieved with existing near-field tools. I propose a new kind of microscope: a far-field super-resolution magnetic correlation microscopy platform. Building upon progress in the field of magnetic microscopy using defects in diamond, including our recent results studying chiral-magnetic hybrid devices, this unique platform will constitute a leap forward over state-of-the-art magnetic sensing techniques. It will enable for the first time local nanometer scale magnetic correlation data unattainable by other means. I will employ these ground-breaking capabilities to reveal the dynamics related to excitation creation and control in 2D magnetic materials and current/spin conductance, leading to breakthrough magnetic device architectures.

Keywords: magnetic microscopy with defects in diamond,magnetic correlation microscopy,hybrid electronic magnetic devices,magnetic memories and switches
Additive Manufacturing of Amorphous Metals for Soft Magnetics (AM2SoftMag)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Italy,Spain,Poland
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-03-01
End date: 2026-02-28
Duration (months): 48.0
Total project cost (EUR): 3450856.0
EU funding (EUR): 3450856.0
Participants: 7
Project status: SIGNED

AM2SoftMag is working toward the vision that, one day, 3D printing will become the de facto standard technology for the manufacturing of high-performance amorphous soft-magnetic components for highly efficient electrical machines and passive electrical components. To prove the viability of the approach, the partners expect to demonstrate superior operating efficiency of an electric motor comprised of soft-magnetic stator and rotor components created by means of selective laser melting (SLM) of soft-magnetic bulk metallic glass (BMG) alloys and powders specially designed and optimized for the additive manufacturing (AM) process. Adding to the already outstanding magnetic and mechanical properties of BMGs, this incremental casting process overcomes the wall thickness limitations of conventional metallic glass casting processes, enables the energy-efficient near net-shape production of complex geometries not achievable by other means and opens up avenues for the digital design of micro-localized properties throughout the components. Furthermore, the method will expand the spectrum of manufacturable and recyclable amorphous metals thereby increasing the availability of alloys with unique magnetic and mechanical properties while reducing or eliminating the need for environmentally critical elements such as cobalt. We establish a long overdue cooperation among academic and industrial leaders in the fields of metallic glass design and processing, mechanical and magnetic testing, quality control and certification as well as design and testing of electrical machines. Through the design of powdered amorphous soft-magnetic alloys, optimization of SLM process parameters and verification of resulting electromagnetic devices, we will achieve major breakthroughs in the flexible and energy-efficient production of superior soft-magnetic components thereby enhancing the energy efficiency of electrical devices and thus substantially contributing to the European Green Deal.

Keywords: additive manufacturing am,bulk metallic glasses bmg,soft magnetic materials smm,powders,selective laser melting slm,metal 3d printing,eco design,energy efficiency,european green deal
Profiling NMDA receptor in schizophrenia and predicting clinical trajectories from rsEEG using dynamic causal modelling (NMDAR-DCM)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: CLOSED

The richness of chemical signalling in the brain supports the flexible neural dynamics required for adaptive behaviour. The NMDA receptor, one of the most ubiquitous receptors in the brain, controls synaptic plasticity and mediates learning and memory formation. Its dysfunction is theorised to be one of the mechanisms of schizophrenia. Profiling the changes and dysfunctions of ion channel receptors can elucidate the biological substrate of functional brain impairments and facilitate individual patients’ personalised treatment strategies. The aims of this project are two-fold: methodological—developing a robust and translational dynamic causal model able to profile NMDA-R dynamics—and clinical—studying NMDA-R dysfunctions and their trajectory within a longitudinal study of a large cohort of schizophrenic patients. The NMDA-R DCM will first be developed and validated on animal data with a high signal-to-noise ratio. The ground-truth dataset comes from a repeated measures study, with one of the measurements involving a pharmacological intervention using an NMDA-R blocker. Next, the model will be translated to human rsEEG data with the same within-subject design. Finally, the validated NMDA-R DCM will be applied to schizophrenic patients. The prospective design of the study will allow for the assessment of the predictive power of generative embedding for individual patients’ clinical trajectories. This approach might help clinicians predict clinical outcomes and tailor treatments to individual patients. We plan to disseminate the project’s results through two main channels: peer-reviewed publications of both methodological and clinical advancements, and by sharing the relevant source code for the analyses, including the envisioned additions to the TAPAS package, thereby fostering replicability, reproducibility, and rapid distribution within the community. Ultimately, this project aims to help establish computational assays as a standard procedure in clinical practice.

Keywords: nmda receptor schizophrenia dynamic causal models generative embedding resting state eeg ketamine
Studying Threads Intricately Complex Hydrodynamics (STITCH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 2380750.0
EU funding (EUR): 2380750.0
Participants: 1
Project status: SIGNED

When knitting meets fluid dynamics. Knitting generates fabrics by meticulously guiding yarn into interlocking loops and stitches. Inspired by the legacy of this ancient craft, we propose to study the formation and deformation of complex entangled assemblies “stitched” by the liquid rope coiling instability. We will study the periodic stichlike patterns forming when a viscous thread falls and buckles onto a moving substrate, such as the coils created when honey is poured onto toast. Here, we focus on the case of solidifying liquids that “freeze” the patterns formed by these flows into structured solids. In turn, these structures can be leveraged to achieve tunable mechanical properties. This approach is an instability-augmented version of 3D printing where fluid dynamics co-fabricates the parts, e.g., by coiling and layering fused thermoplastics filaments. Despite their singular potential for materials’ design and fabrication, our understanding of these complex flows remains sparse, leaving outstanding scientific questions unanswered. STITCH will fill this gap of knowledge and elucidate the intricate relation between flow, form, and function. We will integrate rigorous experimentation and modelling techniques to rationalize how our liquid patterns fuse into resilient solid composite materials. This deeper understanding will allow us to tame instabilities in solidifying melts, serving as the foundation for engineering precisely crafted architected solids across length scales, potentially impacting diverse sectors, from tissue engineering to construction. We will leverage our findings to push innovative frontiers in manufacturing with the ambitious and high-risk goal of developing aerial printing methodologies, where one or more drones work together to build from the sky. Our fundamental work is dedicated to materializing this nascent paradigm, bringing it from the realm of science fiction into concrete reality.

Keywords: mechanical instabilities,free surface flows,elastic threads
Sustainable Energy Applications for Green and Low-impact Operation of small-scale fishing boats in the Baltic and North Sea basins (SEAGLOW)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Ocean, seas and waters
Destination: Ocean, seas and waters
Action type: Innovation actions
Countries involved: Denmark,Norway,Germany,Sweden,Spain,Belgium,Estonia,Thailand
Call: Lighthouse in the Baltic and the North Sea basins - Lighthouse in the Baltic and the North Sea basins - Green and energy-efficient small-scale fishing fleets (HORIZON-MISS-2023-OCEAN-01, 2023)
Start date: 2024-05-01
End date: 2028-04-30
Duration (months): 48.0
Total project cost (EUR): 5088912.76
EU funding (EUR): 4546441.82
Participants: 16
Project status: SIGNED

The project SEAGLOW (Sustainable Energy Applications for Green and Low-impact Operation of small-scale fishing boats in the Baltic and North Sea basins) will demonstrate the impact and potential of 5 different technological applications to reduce fossil fuel consumption and GHG emissions on small fishing boats in the North and Baltic Sea basins. The project will focus on comparison of available technologies through the industrial partners of the project as well as work towards developing and improving the applied technologies through the data collection from the applied cases with the goal of decreasing the environmental impact of the vessels. SEAGLOW will collect sensor data from the case vessels to measure the impact of the applied application over time as well as look into potential combinations of the technologies, which include hybrid electric drivetrains, methanol powered engines, durable polymer-based surface coatings preventing fouling, reducing drag and improving engine performance, to use of low-cost permanent sensors to influence sailing behaviour. The technologies will be tested on vessels from 8.5 – 11.5 tons in full operational conditions on 4 vessels in Denmark, Estonia, Norway and Sweden
Photonic Integrated Circuits For Access System in Telecom (PIC-FAST)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Portugal
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2024-03-01
End date: 2026-02-28
Duration (months): 24.0
Total project cost (EUR): 3491968.75
EU funding (EUR): 2444378.1
Participants: 1
Project status: SIGNED

The number of internet-enabled users, devices and bandwidth-hungry applications is increasing constantly, and network operators are struggling to meet the demand for more bandwidth. The problem is most acutely felt by end users of fixed broadband connections, typically served by passive optical networks (PONs): speed throttling and connection drop-outs are the most-reported issues. Telecom operators are typically too margin-stressed to invest in entirely new infrastructure and have to maximise returns on existing PONs. Developments to deliver higher transfer rates currently focus on discrete optical components, which have reached their limits in terms of scalability, performance, footprint, power consumption, reliability and cost. The integration of optical components into Photonic Integrated Circuits (PICs) offers a new technology trajectory that will overcome these limitations, but the increasing component density this entails has challenges. Through a string of successful R&D projects conducted in world class facilities by an expert team, PICadvanced has laid the foundation for a novel PIC design serving as a platform for an entirely novel generation of optical transceivers, specifically Optical Network Units (ONUs) deployed at end user premises. This overcomes the current limit of 2.5Gbps and offers higher bandwidths with minimal upgrades of end user hardware while fulfilling the strict requirements of the telecom sector regarding footprint, power consumption and cost. Our demonstrator will achieve 10Gbps, open a technology roadmap towards 25Gbps/50Gbps and enable the telecom sector to achieve a better quality of service, higher customer satisfaction and more efficient utilisation of existing fibreoptic network assets. We will also demonstrate how this new generation of fast broadband technology can be delivered to end users with a lower environmental footprint by reducing raw material input, 40% lower hardware costs and 20% lower energy consumption.

Keywords: passive optical networks pons,optical transceivers,photonic integrated chips pics
SuPErConducTing Radio-frequency switch for qUantuM technologies (SPECTRUM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Sweden,Germany
Call: EIC Transition Open 2021 (HORIZON-EIC-2021-TRANSITIONOPEN-01, 2021)
Start date: 2022-05-01
End date: 2025-04-30
Duration (months): 36.0
Total project cost (EUR): 2499222.0
EU funding (EUR): 2499222.0
Participants: 6
Project status: SIGNED

Despite the high expectations and numerous announcements that have been made over the past ten years, the spread of Quantum Computers (QCs) is still in its infancy. The major factors limiting the diffusion and market penetration of QCs are their low scalability and high cost. Both issues are connected to the bulkiness and complexity of the signal lines that operate the QC. The required large amount of cables undermine the scalability and decrease the thermal stability of the Quantum Processing Units (QPUs). With this project, we aim to increase the scalability and reduce the thermal issues of QPU developing a radiofrequency (RF) switch, QueSt, that allow to simultaneously control the state of multiple qubits through the same cable. QueSt goes well beyond what is achieved with state-of-the-art electronics that typically provide bulky, slowly and energy inefficient solutions. The core component of QueSt is an all-metallic superconducting transistor-controlled via gate voltages. This transistor exploits the peculiar characteristics of a superconducting material to work at frequencies (~1 THz) unachievable with classical semiconductor electronic components and with nearly zero power dissipation. During SPECTRUM we are going to build a complete test platform QueSt devices. The state-of-the-art nanofabricated prototype of QueSt will be tested in a custom made cryostat able to unleash the true potential of this technology. Furthermore, ultra-fast FPGA-based electronics will take the case of the control of multiple switches, providing an affordable and performant control over the prototype. This platform will be the environment in which QueSt will be studied at strict contact with the state of the art Quantum Processing Units. The experiments performed in real Quantum Computer under the EU-funded Spectrum project will be the first step to the true Quantum Revolution.

Keywords: quantum computing,field emission transistor,radiofrequency switch,cryogenic electronics