Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Moral emotions in politics – how they unite, how they divide (MORES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Poland,Belgium,Hungary,Italy,Germany,France,Israel
Call: The emotional politics of democracies (HORIZON-CL2-2023-DEMOCRACY-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2960000.0
EU funding (EUR): 2960000.0
Participants: 10
Project status: SIGNED

Liberal democracy is struggling with the challenge of citizens’ indifference and detachment from politics, while anti-system politicians are overemotionalising policy issues which furthers polarisation in society. The normative stance of MORES is that both under- and overemotionalisation of politics should be avoided. The former leads to the affective disconnect of citizens from politics, while the latter spurs tribal politics and hampers deliberation – both extremes threaten democracy. MORES argues that moral emotions and moralised political identities – a conceptual innovation of the project – have a practical value in dealing with the challenges of affective politics. Moral emotions are linked to the interests or welfare of society or at least of persons other than the subject itself. They can unite people towards common causes or split them along moralised political identities. MORES applies a horizontally wide research logic to build a normative-analytical framework to inform democratic decision-making on how moral emotions should interact with values, policies and political practices. MORES will create state-of-the-art methods and generate new empirical data on (1) the type of moral emotions triggered by political actions and phenomena such as campaigns, leadership styles and illiberal politics; (2) the role of moral emotions in forging moralised political identities; (3) the effect of moral emotions on political behaviour such as policy support and civic activism; and (4) the contextual social phenomena, including digital universes, of the moral emotions-politics nexus. Through research engagement with key stakeholders, MORES will create several innovative tools including a method for policymakers to measure the emotional valence of policies, games to strengthen citizens’ political-emotional resilience both in real-life and metaverses, and policy ideas to embed citizens’ moral-emotional needs in policymaking towards bolstering trust in democratic governance.

Keywords: moral emotions,moralised political identities,democratic governance and policymaking
Computational design of synthetic antibody repertoires for accelerated therapeutic discovery (CADABRE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-08-01
End date: 2029-07-31
Duration (months): 60.0
Total project cost (EUR): 2741000.0
EU funding (EUR): 2741000.0
Participants: 1
Project status: SIGNED

Synthetic human antibody repertoires are an important source of therapeutics; however, antibodies often exhibit undesirable developability liabilities, such as low stability, solubility, and polyreactivity, that limit their potential as drug candidates. CADABRE will design next-generation repertoires comprising billions of diverse human antibodies that exhibit excellent developability properties, with the following aims: 1. Repertoire design: We will use our newly developed combinatorial Rosetta atomistic design paradigm to select human germline genes and design H3 multipoint mutants. These will combine into billions of diverse, low-energy, and foldable full-length antibody variable domains for expression in a phage-displayed repertoire. The repertoires will comprise hundreds of possible germline gene combinations, increasing the structural diversity relative to existing repertoires and the odds of obtaining diverse antibodies toward any antigen. 2. Learning developability principles: High-throughput screening will identify heat-stable antibodies that are not polyreactive. Data from deep sequencing will be used to train an AI-based predictor of these properties that will be used to improve the repertoire and rank antibody candidates. We will iterate repertoire design, screening, and learning until we converge on a repertoire that exhibits excellent properties. 3. Verifying relevance to therapeutic discovery: We will select antibodies that target antigens that represent relevant drug targets, verifying that the antibodies exhibit high stability, affinity, and developability. CADABRE combines the strengths of our protein-design methods (generating stable antibodies) and phage-display screening (unbiased binder selection). It will deepen our understanding of the biophysical underpinnings of antibody developability, develop new methods for ranking drug candidates, and generate new repertoires that will accelerate the discovery of life-saving therapeutic antibodies.

Keywords: rosetta atomistic design antibody developability phage display high throughput screening
Deciphering the internalization profiles of mGlu receptors (GLUGLU)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

G protein-coupled receptor (GPCR) are membrane proteins targeted by around 30 % of all marketed drugs. GPCR internalization is a mechanism that tunes the cell surface versus intracellular receptor ratio, a parameter that plays an essentiG protein-coupled receptor (GPCR) internalization is a mechanism involved in the tuning of cell surface versus intracellular receptor ratio, a parameter that plays an essential role in controlling receptor physiological responses. This process is very well described for many GPCRs but surprisingly not for metabotropic glutamate receptors, mandatory dimeric GPCRs that are ubiquitously expressed in the brain to regulate neuronal transmission. Deciphering which are the internalization pathways related to mGlus emerge as a strategy for the regulation of their response to not only drugs but also endogenous neurotransmitters. I propose to examine the internalization profiles of mGlus in brain cells and to unravel the structural and molecular mechanisms involved in the process. I will use a biophysical technique optimized by the host team that allows the real-time and quantitative measurement of receptor internalization in both recombinant cells and brain cells, in combination with a microscopy approach that will complement the analysis. On top of that, I will use nanomolar range affinity nanobodies, single domain antibodies that have already been developed by the host team as a tool for ultimately elucidate which are the internalization profile of mGlus in brain cells. As a consequence of this project, the internalization profile of mGlus in neurons and astrocytes, and the cell machinery responsible for this process will be clarified for the first time. This knowledge will allow the fine-tuning of mGlus localization in the cell, as well as the validation of the nanobodies as a tool for studying endogenous mGlus. These outcomes will upgrade the current resources that the scientific community has to modulate mGlu receptor-mediated responses.

Keywords: g protein coupled receptors,metabotropic glutamate receptors,internalization,receptor trafficking,receptor signalling,endogenous receptors,nanobodies
Revolutionizing Intracranial pressure (ICP) measurements (FAST-ICP): A novel, rapid, real-time, non-invasive method for accelerated diagnosis and treatment (FAST-ICP)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Norway
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 48.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Intracranial pressure (ICP) is a critical diagnostic marker for several neurological conditions like traumatic brain injury (TBI), stroke and hydrocephalus. Raised ICP is a medical emergency that can cause permanent brain damage or death. Current invasive ICP measurement method involves placing a sensor in the brain and is only performed on 0.05% critical patients, often delaying diagnosis and treatment. Nearly 50% of admitted TBI patients die due to increased ICP. There is an unmet need for a new method that provides fast, accurate, and real-time ICP measurement to accelerate diagnosis and enable life-saving decisions. Accurate ICP monitoring could reduce mortality, improve stroke prognosis, and guide hydrocephalus treatment. Nisonic has developed a first-in-class, non-invasive, rapid and easy-to-use method (FAST-ICP), that utilizes ultrasound images of the eye to measure ICP. Our method exploits the effects of raised ICP on geometry and stiffness of the optic nerve sheath (ONS). We have established a novel parameter ‘Deformability Index’ for measuring ONS stiffness, which along with ONS diameter and optic disc elevation provide accurate ICP measurement, comparable to the invasive method. FAST-ICP utilizes AI-ML models for automatic processing and analysis of ultrasound images to provide real-time ICP measurement. It can be accessed at versatile point-of-care sites like surgery room, ambulance and at patient bedside, enabling early diagnosis and improve treatment outcomes. FAST-ICP system has global market opportunity of €972Mn. We have completed proof-of-concept studies and have established the largest database in the world of ultrasound images with on-going clinical studies. We request EIC funding for blended finance to reach milestones of software development, perform pivotal trials and obtain regulatory approvals for market entry in US and Europe.

Keywords: intracranial pressure icp,ultrasound imaging analysis,cloud system,neurological disorders
Verified and Passportable Financial Identity (EU-CREDIT-AI)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Estonia
Call: EIC Accelerator Open 2024 (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 3571427.14
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Mifundo OÜ, an Estonian fintech founded in 2018, is developing the first cross-border AI and data platform. We provide a technology layer to passport credit histories across borders through one single API. Today's bank lending is country-based and there is no solution available across the EU, making cross-border borrowing almost impossible. No single party, bank or credit bureau is interested in solving a problem that requires such a high investment. Mifundo is removing the barriers between people and banks in the EU that eliminate over 45 million people from having access to financial services, due to highly fragmented nature of data. Despite being new to the market, Mifundo has achieved success, becoming a member of ACCIS (world's largest credit reference agency) and FinanceEstonia (financial sector representative organisation supporting the Estonian economy). Mifundo enables financially excluded European expats to access capital by passporting credit histories across borders, reducing loan disparities and discrimination by nationality, and improving financial literacy. Additionally, banks do not need to perform credit analysis as Mifundo provides it and ensures local compliance. By leveraging diverse data sources and generating new data points, the platform enhances the credit score model's accuracy. The main objectives of the EIC Accelerator project are data collection and standardisation, credit risk score development, regulatory compliance and developing AI engine for credit risk assessment. This funding accelerates platform development, enhances risk assessments with cutting-edge technologies, establishes partnerships, ensures compliance and expands the user base. Mifundo aims to become the leading crossborder credit service provider in the EU.

Keywords: fintech,financial passport,artificial intelligence,machine learning,statistical data processing,cross border
Sustainable Agriculture through Precision Robotics and AI (SAPRA)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

We are an agricultural technology startup with the mission to make sustainable farming profitable at large scale through robotics and Artificial Intelligence. With a focus on addressing critical issues such as labor shortages, environmental sustainability, and the high cost of organic farming, our technology revolves around farming automation and digitization. We reduce manual labor and operational costs for farmers while improving crop management through data-driven insights. E-TERRY is an autonomous agricultural robot that automates and digitizes field processes. The robot is a multifunctional open implement carrier that can be equipped with different tools for weeding, spraying, drilling, transporting, or harrowing. As a first commercial application, our agricultural robot mechanically removes weeds from onions and sugar beet crops. E-TERRY achieves an impressive weed removal rate of 80%, significantly outperforming our main competitors (53% to 64%), cuts 40% of the manual weeding costs and offers streamlined operation saving up to 360 h/ha of manual work per season. Our agricultural robot achieves precision agriculture through the integration of cameras and sensor systems backed by a computer vision algorithm that enables monitoring on a per-plant level allowing farmers to assess crop quality, number of weeds, biomass and microclimate.

Keywords: sustainable agriculture,automation,weeding as a service
Ecologies of Violence: Crimes against Nature in the Contemporary Cultural Imagination (EcoViolence)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The ongoing destruction of the natural world raises critical questions about responsibility. How do we remember the victims, both human and non-human? And who is to blame? Contemporary culture plays a crucial role in addressing these questions. Large-scale processes like ecocide and extinction pose significant conceptual and representational challenges. This project posits that writers, artists and filmmakers are responding to these challenges by adapting existing repertoires, especially ones that emerged in response to the Holocaust, slavery, and other atrocities. In so doing they reveal the historical, structural and discursive links between crimes against humanity and crimes against nature. EcoViolence will be the first comprehensive, transnational, comparative study of the cultural imaginary of environmental violence. Bringing together recent work in cultural memory studies and ecocriticism, we will develop an innovative ecological model for the study of violence and its representation. We will document how texts, films, art works, plays and exhibitions represent ecoviolence; map how they link it to colonialism and genocide; and analyse how they reflect on questions of guilt and responsibility, as well as culture’s own implication in the violence it depicts. Furthermore, we will explore how these representations harness affect and emotion to help people relate to the environmental crisis and promote critical self-reflection. EcoViolence will effect a major reorientation in cultural memory research and ecocriticism by providing a framework to think about violence and memory in more-than-human terms. The project will result in a “best practices” guide to engage cultural representations in pedagogy to enhance critical literacies about ecoviolence and move beyond simplistic stories where everyone is either a victim or a perpetrator that have stifled full responses to our collective ecocidal trajectories.

Keywords: cultural memory environmental humanities representation responsibility affect
Innovative dynamic Façade systems for INdoor environmental Quality (FaceINQ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands,Ireland
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2024-03-31
Duration (months): 15.0
Total project cost (EUR): 127165.2
EU funding (EUR): 127165.2
Participants: 3
Project status: CLOSED

Buildings are the single largest energy consumer in Europe and addressing the challenges of climate change require innovative approaches to building design and operation that reduce energy consumption. Furthermore, people spend most of their lives in buildings; thus, the quality of indoor environments, and indeed indoor air, is vital. The recent Covid-19 pandemic has shown some of the health risks associated with poor ventilation and demonstrated that improving indoor air quality requires urgent attention and next-generation thinking. However, with energy efficiency being a priority when designing new and retrofitting old buildings, there is a challenge to balance this with ensuring indoor environment does not impair the health, comfort, wellbeing and productivity of building occupants. FaceINQ is an exciting project that addresses the need for innovation in the design and operation of naturally ventilated buildings with complex glass façade systems, which are now a common feature in large-scale non-residential buildings. FaceINQ’s innovative approach utilises advanced computational models validated with measured data and qualitative feedback from building occupants to consider not only the building energy consumption, but also the impact of indoor environment on building occupants, and the impact of occupants’ behaviour on the operation of façade systems. Through an interdisciplinary and intersectoral approach (i) combining architecture, engineering, building physics, health and social science, (ii) utilising a ‘living laboratory’ to collect extensive data, and (iii) enabling non-academic short visits and a placement to enhance the transfer of knowledge between industry and academia; this novel research will provide a paradigm shift in the design, assessment and operation of naturally ventilated buildings. The results will enable society meet urgent challenge of providing climate-friendly buildings that are healthy, comfortable and productive places for people.

Keywords: computational fluid dynamics on site measurements qualitative user feedback indoor environmental quality health,comfort,wellbeing and productivity energy efficiency building fa ade system
Uncovering the mechanisms of action of an antiviral bacterium (Mechano-Wolbachia)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Poland
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Animals and microbes interact in intricate ways. Wolbachia, a common intracellular insect symbiont, can manipulate reproduction and protect hosts from viruses. Thus, Wolbachia is an asset in the control of insect-borne diseases. However, as Wolbachia cannot be cultured outside of host cells or genetically manipulated, the mechanisms of its antiviral phenotype remain poorly understood, and this inhibits wider exploitation. I have been working to remedy these deficiencies, and now stand poised to discover the mechanisms of Wolbachia-conferred antiviral protection by answering the following questions: 1) Where does the protection originate? Up to now, mechanisms of protection have been studied in whole organisms, often lacking resolution, or in cultured cells, which lack emergent properties. I will identify tissues and cell types of the host where protection starts. To do this, I will: a) quantify titers of Wolbachia and virus at early time points post-viral infection in insect tissues, b) measure gene expression of host and microbes to identify candidates for further molecular characterisation, and c) test the extent of the utility of widely adopted, yet unvalidated, cell-culture models of antiviral protection. 2) Which Wolbachia genes effect protection? Wolbachia research has historically been impeded by a lack of tools to study gene function. Here, I will deploy antisense technology, which I have recently developed, to interrogate function of candidate Wolbachia genes in the native system. I will also engineer new methods to target Wolbachia genes and proteins, based on my data on cell-penetrating peptide-mediated delivery of bioactive cargo to Wolbachia. This project has two major outcomes: it will uncover Wolbachia factors responsible for Wolbachia-conferred antiviral protection, and it will transform Wolbachia and symbiosis research by creating tools to study symbiont gene function.

Keywords: defensive symbiosis,wolbachia,host microbe interactions,antiviral protection,antisense inhibition,transcriptomics,novel tools to study unculturable bacteria