Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Tracking gluten immunoreactive peptides from the grain to the gut and beyond (GLUTENOMICS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1499988.0
EU funding (EUR): 1499988.0
Participants: 2
Project status: SIGNED

Wheat is one of the pillars for nutrition security worldwide, but the prevalence of wheat-related disorders (WRD) is increasing. Taken together, coeliac disease, non-coeliac gluten sensitivity and wheat food allergy may affect up to 10% of European individuals. The causes for this increase are still unknown, but involve the intricate interaction of proteolytically resistant gluten immunoreactive peptides (GIP) from wheat, rye and barley, the human immune system and yet unknown adjuvants. Total GIP can be detected by immunoassays in human plasma, urine and faeces (biosamples) after gluten consumption, but the precise molecular structures have not been clarified so far, because specific analytical methods are missing. The project GLUTENOMICS aims to elucidate the molecular structures of GIP in human biosamples and analyse factors determining their identities and quantities. I aim to achieve this using a combination of different approaches to overcome the analytical challenges by i) creating a comprehensive database of GIP and elucidating factors affecting gluten protein digestibility, ii) developing and validating proteomics methods to detect GIP in human biosamples and iii) establishing relations between the GIP profile of raw materials, foods and human biosamples. My central hypothesis is that gluten structure and content determine its digestibility which, in turn, leads to different GIP profiles in biosamples from healthy individuals and WRD patients. The unique toolbox of methods that I will put in place will provide a fundamentally new understanding of how protein structures govern digestibility and how the resulting peptides pass through the human digestive system. My ambition is to use the findings to tailor grain-based foods towards better tolerability to prevent the initial onset of WRD. Beyond grains, GLUTENOMICS opens significant innovative potential to promote human health through systematically structured, isolated or designed dietary proteins.

Keywords: food hypersensitivities food proteomics protein digestibility
Gamma-secretase allosteric modulation as preventive therapy in Alzheimer’s Disease (GALOMOD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Belgium
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-09-01
End date: 2026-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

The recent advent of therapeutic Aβ-antibodies has validated amyloid plaques as drug targets in Alzheimer’s Disease (AD). They remain expensive, prone to side effects, and clinical benefit is limited. The field needs a safe and cheap drug, preferably a small compound that can be taken orally, and in a preventative way before brain damage has occurred. Despite strong theoretical potential, further clinical development of gamma-secretase allosteric modulators (GAM), is currently hampered by the lack of strong experimental evidence that they are safe and can effectively prevent AD. In this POC we will exploit findings of our ERC grant Cellphase-AD to generate such evidence. We developed an innovative xenotransplantation model beyond the classical mouse models, as it shows not only amyloid plaques, but also the induction of neuro-inflammation, real Tau-pathology, granulovacuolar neurodegeneration, and secretion of Tau biomarkers in the blood, all characteristic of AD (PMID37708272). We will treat this model in collaboration with a contractor with a newly developed compound to demonstrate that this GAM can prevent in a safe and effective way this AD pathology. Using an innovative unbiased ʏ-secretase assay we will provide direct evidence that this GAM, in contrast to the previously failed gamma-secretase inhibitor Semagacestat, maintains normal processing and signalling and does not show mechanistic driven side effects. The experiments aim to support the concept that GAM can be developed as preventative medication in both sporadic and familial AD and to bring the compound forward to clinical trialing.
A EUROPEAN-WIDE NETWORK OF PILOT FARMERS IMPLEMENTING AND DEMONSTRATING CLIMATE SMART SOLUTIONS FOR A CARBON NEUTRAL EUROPE (Climate Farm Demo)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Coordination and support actions
Countries involved: France,Belgium,Bulgaria,Croatia,Finland,Greece,Hungary,Ireland,Italy,Latvia,Lithuania,Austria,Netherlands,Poland,Portugal,Romania,Serbia,Slovakia,Slovenia,Spain,Sweden,Germany,Switzerland,United Kingdom,Estonia,Luxembourg,Denmark
Call: Demonstration network on climate-smart farming – linking pilot farms (HORIZON-CL6-2021-CLIMATE-01, 2021)
Start date: 2022-10-01
End date: 2029-09-30
Duration (months): 84.0
Total project cost (EUR): 21487127.16
EU funding (EUR): 21487127.16
Participants: 92
Project status: SIGNED

Climate Farm Demo is a unique pan-European network of Pilot Demo Farmers (PDFs) covering 28 countries and all pedo-climatic areas. Its overall aim it to accelerate the adoption of Climate Smart Farming (CSF) practices and solutions by farmers and all actors of the Climate Smart Agriculture Knowledge & Innovation Systems with a view of adapting agricultural production systems to climate change and of achieving a carbon neutral agricultural sector by 2050, thereby meeting the targets of the EU Climate strategy. To reach this objective, the project adopts a Multi-Actor approach by connecting 1500 Pilot Demo Farmers and their Climate Farm Advisors (CFAs) at European and national levels to increase knowledge exchange & cross-fertilisation in their respective AKIS. The CFA’s will support the PDF’s in implementing Adaptation and Mitigation Measures suggested by contextualised guidelines and will assess & monitor their environmental performance thanks to harmonized methodologies & tools. Technical and social innovations covering a broad range of thematic areas will be demonstrated to the wider farming community across six annual demo-campaigns (4500 demo-events) supporting interactive and peer to peer learning. New and innovative CSF solutions will be co-created in 10 Living Labs spread across Europe and lessons learned from multi-actor innovation will be shared and scaled. A set of public and private rewarding mechanisms will be identified, proposed and demonstrated to the AKIS actors, thus incentivising the uptake of CSF solutions while ensuring sustainable business models. Strategic and operational cooperation will be organised with projects, flagship initiatives and policy-makers at European and national levels in order to share knowledge, organize coordinated actions, and produce policy briefs. Finally, to accelerate the wide spreading and uptake of results, an ambitious dissemination, exploitation and communication strategy will be deployed at EU and national levels

Keywords: climate smart farming,adaptation and mitigation measures,farm demonstrations,networks,multi actor approach,rewarding mechanisms,living labs,advisors,akis,knowledge,tools,policy,cap
Promoting Opportunities for Wide-scale Energy Renewal: Unlocking Potential (POWERUP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Coordination and support actions
Countries involved: Spain,Italy,Portugal,Greece,Germany
Call: Market Uptake Measures of renewable energy systems (HORIZON-CL5-2024-D3-02, 2024)
Start date: 2025-11-01
End date: 2028-10-31
Duration (months): 36.0
Total project cost (EUR): 1995480.79
EU funding (EUR): 1995480.79
Participants: 9
Project status: SIGNED

The market uptake of RES depends on a complex combination of political, geographical, economic, social and cultural factors that are specifically intertwined in each locality. In addition, the acceptance and willingness of directly affected stakeholders to support the deployment of RES depends on the perceived fairness about how the decisions are made (procedural justice) and how the benefits are shared (distributive justice). POWERUP adopts a holistic approach towards the market uptake of RES for electricity and provides a set of open source tools and methodologies addressing all these factors, tailoring the RES projects to the local conditions and increaseing their acceptability and market uptake. The tools include a GIS-based decision support tool for initial feasibility assessment, a business model toolkit for reconciling stakeholder requirements and producing equitable business models, and a co-creation toolkit for engaging the stakeholders in co-design of a RES project that is reproducible and tailored to the local needs and conditions. The tools are supported by a social acceptability strategy for RES that provides guidance for considering all social aspects in the decision-making and design process. The POWERUP tools and methodologies will be extensively validated in 4 European regions and replicated in 10 follower regions, covering a variety of conditions all over Europe. The project aims to involve >700 public and private stakeholders and organise 46 workshops, incresing the perception of fairness of the RES business models by 80% and the community acceptance by at least 50%. The project consortium is a team from 5 EU countries that comprises regional energy agencies, public authorities, universities, and research centres and includes leading experts in Social Science and Humanities, Business, Renewable Energies, ICT and data science, legal and regulatory framework, with large practical experience in promotion of the renewable energies uptake.

Keywords: social acceptability strategy for res business model framework for res decision support tool stakeholders engagement acceptable res renewable electricity
Recharge and Evapotranspiration Characterizations through Holistic Assessment for Responsible Groundwater managEment (RECHARGE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-04-01
End date: 2027-06-30
Duration (months): 27.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 2
Project status: SIGNED

Mediterranean “analogue” environments across the world have seen increased frequencies of droughts, with repercussions such as reduced availability of soil water for the vegetation. This situation forces plants to shift from soil water to groundwater for photosynthesis. Climatic adaptation plans have shown that sustainable management of groundwater resources cannot ignore areas with vegetation groundwater uptake and needs to account for the quantification of recharge to the groundwater and evapotranspiration, which are linked through processes happening in the critical zone. Dr Simone Gelsinari was inspired by the approach adopted for managing water resources by Australian regulatory agencies and formulated the project “Recharge and Evapotranspiration Characterizations through Holistic Assessment for Responsible Groundwater manaEment – RECHARGE”, with a core field observational part to be performed at the University of Florence and a secondment at the CNR for the modeling component and the possibility to interact with policymakers. RECHARGE will promote the recognition of vegetation adaptation characteristics to non-stationary climates and the need for regulators to account for these characteristics in climate adaptation plans. RECHARGE will be the continuation of the Fellow’s interdisciplinary background given the mixed experience in modelling and field data instrumentation and collection that he maturated in the last 6 years spent in a semi-arid Mediterranean environment since both PhD and Postdoc were based in Mediterranean-like climatic areas in Australia. RECHARGE will be the opportunity to bring back and apply to the EU his experience developed through extensive exposure to Australian climate adaptation approaches. The Fellow’s goal is to be positioned at the interface of the field and modelling communities, within the broad area of hydrology and climate sciences, and he maximizes both experiences at the host and secondment institutions to reach this goal.

Keywords: recharge to groundwater,evapotranspiration,
Piloting Underground Storage of Heat In geoThermal reservoirs (PUSH-IT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Innovation actions
Countries involved: Netherlands,Germany,France,Czechia,Switzerland,United Kingdom,Belgium
Call: Demonstrate the use of high temperature geothermal reservoirs to provide energy storage for the energy system (HORIZON-CL5-2022-D3-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 19763180.01
EU funding (EUR): 17903348.29
Participants: 25
Project status: SIGNED

PUSH-IT will showcase full-scale application of high temperature heat storage (up to 90°C) in geothermal reservoirs using 3 different technologies at 6 different sites. The 3 technologies addressed in PUSH-IT are relevant for different reservoir types, which are available everywhere in Europe. In PUSH-IT we will develop, deploy and test our technologies for a variety of configurations of heat sources, heat storage technologies, geological conditions, distribution systems, stakeholder populations and market and legal conditions. Hence, PUSH-IT provides a unique scope on demonstration, integration and advances for seasonal heat storage that are relevant across Europe. These results will enhance the utilisation of sustainable energy and create a balanced system for sharing benefits and burdens tied to sustainable heat generation, storage and distribution activities. We will reduce environmental impact, levelised cost of energy and risks and improve performance and robustness via development and demonstration of several enabling technologies, i.e., newly developed monitoring and water quality control and novel drilling and completion and novel control systems. Societal engagement is a key element and achieved via citizen engagement, analysing motivations and perceptions of heat storage, and investigating governance policies and business models that engage citizens in decision making regarding urban heating systems including storage. The PUSH-IT consortium combines heat suppliers, well drillers, public planning offices and academic partners. These cover all required technical and societal know-how and background for heat systems. We will realise operational projects and use these to generate generic solutions and practices relevant across Europe. All activities will be monitored and reported, yielding a valuable comprehensive dataset on the technical and social real-world performance.

Keywords: geothermal heat,storage
HUman-WIldlife coexistence through a NUTRitional Ecology lens (HUWINUTRE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-06
End date: 2025-03-05
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: CLOSED

Nutrients are interconnecting threads in the web of life and are vital currencies to most ecological interactions. Despite this, our knowledge of how they shape these interactions remains limited. For over two decades, researchers have documented the rise of agricultural practices in detriment to wildlife habitats in African savannas. These led to an unprecedented increase in the number of interactions between wildlife and local communities, with technical solutions providing limited success and nature-based options still to be adequately tested. A likely explanation is related to the complexity of the socioecological and nutritional dynamics involved. Therefore, exploring HUman-WIldlife coexistence through a NUTRitional Ecology lens (HUWINUTRE) is vital to understand whether wild mammals use human-dominated areas as nutritional subsidiaries to reach their requirements. HUWINUTRE will bring a systems approach to: 1) establish the natural and anthropogenic nutritional landscapes available to wildlife, 2) develop cutting-edge techniques for disentangling the contribution of human-derived foods to the nutritional niches of species with different degree of anthropogenic dependence, 3) explore potential reconciliation actions to improve the coexistence between heterogeneous human communities and diverse wildlife species. The training and knowledge transfer provided by the host institution to the candidate during this fellowship, will create an ideal intellectual environment for this pioneering research. The novelty of this project is the integration of behaviour, nutrition, ecology, and evolution that is pivotal to capture the essential nutritional dynamics that are critical for wildlife conservation and management at both fundamental and applied levels. The project addresses the EU Biodiversity Strategy to 2030, and the UN Sustainable Development Goals of ensuring the conservation, restoration, and sustainability of terrestrial environments.

Keywords: nutritional ecology,human wildlife coexistence
unlocKing the potential of AI-based weatheR forecasts for Operational benefitS (KAIROS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Spain,Belgium,France,Germany,United Kingdom,Finland,Türkiye
Call: Fast Track Innovation and Uptake Capacity-on-Demand and Dynamic Airspace (HORIZON-SESAR-2022-DES-IR-01, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 6030337.5
EU funding (EUR): 3787940.63
Participants: 13
Project status: SIGNED

KAIROS will improve the quality of meteorological information provided to the aviation community through the use of artificial intelligence. By producing accurate digital weather forecasts at longer lead times, aviation stakeholders will be bettered position to mitigate the impacts of weather on their operations. KAIROS will mature the TRL of results from previous SESAR Exploratory Research projects, with the goal of reaching TRL 7 through the completion of operational demonstrations. The project will integrate live weather information from AI forecasts with existing decision support tools and platforms to assess the operational benefits to several end-users. The KAIROS solution will enable a paradigm shift in the management of demand capacity balancing at all levels of the European airspace system including network level, local FMP, and UAM. KAIROS AI-based weather forecasts are intended to be an enabling technology that will unlock operational efficiencies and the automation of planning activities within the airspace system. By providing accurate weather forecasts earlier in the air traffic flow management process, aviation stakeholders including ANSPs, airports, and airlines will be able to formulate strategies to minimize the disruption to their operations.

Keywords: artificial intelligence,digitalisation,weather forecast,airspace capacity,
Optimising Energy Transfer in Hyperfluorescence (HyperDyad)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 188345.36
EU funding (EUR): 188345.36
Participants: 2
Project status: SIGNED

With an ever-growing population, reducing our demand for energy is a key challenge in building a sustainable future. As part of tackling this problem, Organic Lighting-emitting Diodes (OLEDs) show great potential for application in low-energy consumption displays, lighting, and lasers. OLEDs are increasingly featured in high end consumer electronics; however, their potential is yet to be realised. Undoubtedly, the largest problem OLEDs face today is the instability of the blue emitter. Commercial OLEDs currently employ either an inefficient but stable blue emitter (resulting in energy wastage) or an efficient but unstable blue emitter (resulting in short-lived devices). By splitting the task of energy conversion and emission between two molecules within a device, stable and efficient blue emission is achievable. However, the current approach is to disperse these two molecules within a host, which leads to unpredictable orientations and distances between molecules. This results in detrimental processes within the device that reduce both efficiency and lifetime. Traditionally thought to be a device engineering problem, I propose a step change in thought. In a new approach to molecule design, I aim to tether the molecules together using a rigid bridging unit, forming a ‘dyad’ which gives precise control over the orientation and distances within a device. I aim to explore the efficiency of energy transfer as a function of the bridging unit to develop a structure-function relationship. The results of this work will establish design criteria for dyads which will facilitate the development of both efficient and stable blue emitters.

Keywords: organic electronics,organic semiconductors,luminescence,organic light emitting diodes,hyperfluorescence,energy transfer