Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Improving Genome Editing Efficiency (IMGENE) (IMGENE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Germany,Sweden,Czechia,Netherlands,United States,United Kingdom,Portugal,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2017, 2017)
Start date: 2017-09-01
End date: 2021-08-31
Duration (months): 48.0
Total project cost (EUR): 2068409.16
EU funding (EUR): 2068409.1600000001
Participants: 10
Project status: CLOSED

CRISPR genome editing technology is considered to become the greatest technological improvement in biomedical research since the invention of the polymerase chain reaction 25 years ago and pharmaceutical companies as well as academic research are eager to apply it. However, the efficiency of introducing defined changes into the genome by CRISPR is still low, currently limiting its application in basic research, industry and gene therapy. IMGENE unites expert European research groups of academia and industry to address by innovative and complementary approaches the low efficiency of precise genome editing using CRISPR technology. To our best knowledge, IMGENE is the only concerted approach to tackle the important problem of low genome editing efficiency of CRISPR in a multidisciplinary, intersectorial manner. The IMGENE consortium consisting of 6 academic and 1 industrial beneficiary (AstraZeneca), 2 industrial partners (Taconic; MilliporeSigma), and the patient organization Genetic Alliance, aims to improve the genome editing efficiency of CRISPR by research training of 8 ESRs to unleash the full potential of this technology. Combining complementary knowledge on protein chemistry, molecular biology, cellular biology, viral vectors, transgenic mice, gene therapy, and bioinformatics present in the network, IMGENE will establish novel tools and protocols for improved CRISPR genome editing efficiency that will be of immediate benefit for health and life science research, the pharmaceutical industry, and the application of gene therapy. In addition, IMGENE addresses crucial ethical questions related to the application of genome editing technology in animals, plants, and humans, which have to be solved to gain acceptance by the society. By excellent research training of 8 ESRs on a scientifically and economically highly relevant topic and additional training in transferable skills, IMGENE will educate novel leaders with great career perspectives in industry and academia.

Keywords: genome editing,crispr
A comparative study of Countering Violent Extremism through adult migrant language teaching and learning in Denmark and the UK. (CVELANG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: CLOSED

CVELANG adds to growing literature on the increasing prevalence of CVE (Countering Violent Extremism) measures in public life by innovatively examining how learners of language and language education centres deal with policies that cohere to wider governmental, security objectives relating to integration in Denmark and the UK respectively. The integration of migrant communities through the controversial ‘ghetto’ policy in Denmark, which targets socially and linguistically segregated areas, and the Prevent program in the UK demanding educators detect and report those demonstrating signs of radicalisation. CVELANG investigates language teaching in Danish ‘ghettoes’ as well as Prevent in relation to language centres. CVELANG explores how such policies are implemented at a ground level through an ethnographic approach. There are three perspectives to this project: (1) Muslim learners and (2) teachers and (3) management who mediate policy. Little is known about the influence of such policies in adult migrant educational settings which this project will address by centering the experiences of those involved in policy implementation. This allows for space to narrate and define bottom up notions of security and integration and how language-security policies influence ordinary people and institutions in their relations with each other, the state and the national language.

Keywords: security,language learning,immigration,countering violent extremism
Chromatin accessibility landscape and transcription changes in recognition memory after visual imprinting in chicks (CHARM-Vis)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Georgia
Call: Widening Fellowships (H2020-WF-01-2018, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 137391.36
EU funding (EUR): 137391.36
Participants: 1
Project status: CLOSED

The molecular mechanisms underlying memory formation in vertebrates are not well understood, despite their paramount importance to neuroscience. CHARM-Vis aims at investigating changes in the chromatin landscape and transcriptional activity in a prototypical model system for memory formation: visual imprinting in domestic chicks. The expected outcome of the project is remarkable. The use of single-cell, next-generation sequencing technologies will allow to study the system of interest at an unprecedented level of resolution, potentially leading to relevant new discoveries. Novel bioinformatics software pipelines will be developed for analyzing the data, and made available as free, open source software. All the data generated in the project will be made public as well, in order to benefit future research. A highly interdisciplinary consortium of world leading institutions will be involved in the project, including experts in chick visual imprinting from Ilia State University, Georgia, bioinformatics specialists from Navarrabiomed, Spain, and biotechnology experts from Karolinska Institute, Sweden. The combined expertise and synergy of the international consortium, along with the long-lasting scientific experience of the applicant, will ensure the successful fulfillment of the proposal. All the involved parties will greatly benefit from participating into the project. The applicant will deepen his expertise in bioinformatics and neuroscience, reinforcing his position as independent researcher. A mutual exchange of knowledge will take place among the involved institutions, whose know-hows are highly complementary. The project will also have beneficial, long-lasting effects after its end. We expect novel scientific questions to spring from the results of the project, stimulating the applicant as well as other researchers in performing further research, expanding the current knowledge and consolidating their careers.

Keywords: visual imprinting,memory formation,chromatin landscape,single cell transcriptomics,bioinformatics
reSilienT fARminG by Adaptive microclimaTe managEment (STARGATE)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Israel,Germany,Austria,Spain,Italy,Greece,Norway,Greece,Belgium,Poland,Switzerland,Greece,Latvia,Latvia,Czechia,Czechia,Czechia,Czechia,Portugal,Portugal
Call: Climate-smart and resilient farming (H2020-SFS-2018-2, 2018)
Start date: 2019-10-01
End date: 2023-09-30
Duration (months): 48.0
Total project cost (EUR): 6994405.0
EU funding (EUR): 6994405.0
Participants: 29
Project status: SUSPENDED

STARGATEs contribution beyond state-of-the-art in applied climatic data solutions is the implementation of analytics models to support local and regional policy formulation and implementation related to mitigation on microclimate changes. Currently, policy making organizations predominantly utilize own data, typically limited to their own jurisdiction/administrative area. However, once the policy development process expands the evidence base and data sources beyond the traditional approach, there is need for global data. The addition of national, European and even global reference data sets for comparative analysis — including meteorological, climatic analysis, satellite data sources to improve decision making processes. The studies at landscape scale are required to understand leading ecological processes. The focus will be on Climate Smart Agriculture (CSA) and will extensively study the benefits of applying agri-environment-climate technical solutions to achieve sustainable agricultural development at landscape level. It means to support farm management modernization and at the same time get to know the underlying ecological factors that shape the farming landscape. STARGATE will leverage access to this data and also STARGATE climatic platform including developed models platforms to foster easy and affordable adoption by policy making bodies. The simples approach to decision support in policy development is effective visualization of data. Good visualization supports the policy developers’ in modelling sustainable policies and decisions. Unlike algorithmic simulation and modelling, visualization leaves the actual decision and assessment to a human user and thus provides an extra quality assurance before actual policy decisions are made. STARGATE provides innovative components for visualization of big data with a particular emphasis on geospatial visualization and advanced, dynamic charting.
Digital Infrastructures Along the New Silk Road: A Mixed-methods Exploration of China's Digital Investments in Its Borderland Regions (DIGISILK)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Social World and Its Diversity
Panel description: Sociology, social psychology, social anthropology, education sciences, communication studies
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1499236.0
EU funding (EUR): 1499236.0
Participants: 1
Project status: SIGNED

As part of its Belt and Road Initiative (BRI), China has recently launched the “Digital Silk Road” program, focused on investments in digital technologies and infrastructure in countries that are part of its loosely reimagined Silk Road. This program is seen as having the potential to create a second, China-led internet, which splits from the US-centered one and is ruled by a different set of priorities and values. Are the Digital Silk Road and the global expansion of Chinese tech companies prefiguring a future with two internets: an existing one that is US-led and founded on market-driven ideology, and a new, alternative one that is China-led and characterized by state control, national boundaries, and national governance over what began as a borderless new space? What values and politics are built into the various components of the Digital Silk Road, and is - or how is - the internet they are creating fundamentally different from the current one? The project will employ qualitative and ethnographic methods, digital methods, and document analysis to understand the emergence of the Digital Silk Road from the ground-up and from the comparative perspective of business, governments, and ordinary people in four countries: China, where Digital Silk Road policies, finances, devices, online platforms and apps originate; Kazakhstan, a key player in Central Asia; Myanmar, whose economic dependence on China is the cause of considerable ambivalence; and Cambodia, that under Prime Minister Hun Sen has been one of the most enthusiastic supporters of Chinese investments. The project aims at illuminating the deployment of the Digital Silk Road to see what this second internet might consist of; seeks to understand what values and politics are embedded in it; and explores how they are received and negotiated in the countries concerned, thus contributing to the wider debate on values, ethics, and technology.

Keywords: china digital silk road,china belt and road initiative,digital technologies,infrastructure,myanmar,cambodia,kazakhstan,internet,internet governance
Probing many-body localization dynamics using ultracold fermions in an optical lattice (MBL-Fermions)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-01
End date: 2022-06-30
Duration (months): 24.0
Total project cost (EUR): 162806.4
EU funding (EUR): 162806.4
Participants: 1
Project status: CLOSED

The question of how an isolated quantum mechanical system thermalizes is not only significant in condensed matter physics, but it also invokes the intriguing problem of the apparent loss of information in a complex system as it thermalizes. A curious case is when a complex system fails to thermalize altogether -- a phenomenon known as many-body localization (MBL). Here, we propose to use interacting ultracold fermions in a lattice to experimentally study the distinctive properties of MBL using a novel set of observables. Among the questions in MBL debated intensely today are those concerning the existence of a many-body mobility edge, many-body intermediate phase and localization in higher dimensional lattice systems. Moreover, the striking relation between non-ergodicity and Hilbert space fragmentation is also not fully understood. In this view, our research objectives include: [1.] Stark many-body localization and Hilbert space fragmentation. We plan to study MBL in a tilted lattice, i.e., a Stark Hamiltonian and study non-ergodicity resulting from Hilbert space fragmentation. [2.] Bipartite fluctuations in an MBL system of >100 lattice sites: We propose to characterize the localization properties using bipartite fluctuations which is a proxy for the Entanglement entropy of a 1D lattice. [3.] Approximate theories for fermionic MBL systems: Due to the exponential Hilbert space dimension of an interacting many-body system, studying their properties numerically is also exponentially hard. We plan to use a quantum simulator with >100 lattice sites develop efficient approximate theories to describe these systems. The aforementioned projects are easily accessible to the current experimental capability and they will enhance our general understanding of MBL physics. Moreover, they also include a step towards developing ultracold atoms in a lattice into a quantum simulator, capable of solving hard problems.

Keywords: fermionic pptical lattice,many body localization
EMPOWERING AND EDUCATING YOUNG PEOPLE FOR THE INTERNET BY PLAYING (RAYUELA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Research and Innovation actions
Countries involved: Spain,Estonia,Germany,Spain,Estonia,Spain,Spain,Belgium,Belgium,Greece,Slovakia,Belgium,Latvia,United Kingdom,Portugal
Call: Human factors, and social, societal, and organisational aspects to solve issues in fighting against crime and terrorism (H2020-SU-SEC-2019, 2019)
Start date: 2020-10-01
End date: 2023-09-30
Duration (months): 36.0
Total project cost (EUR): 4978040.0
EU funding (EUR): 4974290.0
Participants: 17
Project status: SIGNED

The internet has become an integral part of children and young people’s lives. The increased time spent online is prompting questions about whether they are in control of their internet usage. The low level of awareness of cyber threats and their potential impact is a serious issue that translates into the proliferation of incidents due to human mistakes. 51% of EU citizens feel not at all or not well informed about cyber threats and 86% of Europeans believe that the risk of becoming a victim of cybercrime is rapidly increasing. On the other hand, Law enforcement has noted that more and more teenagers and young people are increasingly committing cybercrimes. This is an international problem which has considerable cost implications; it is estimated that crimes in cyberspace will cost the global economy $445B annually. Understanding the behavioural and developmental aspects of cyber criminality is becoming increasingly important and underlies the necessity of a shift in focus from sanctions to deterrence and prevention. As a research project, RAYUELA aims to bring together law enforcement agencies (LEAs), sociologists, psychologists, anthropologists, legal experts, computer scientists and engineers, to develop novel methodologies that allow better understanding the factors affecting online behaviour related to new ways of cyber criminality, as well as promoting the potential of these young talents for cybersecurity and technologies. RAYUELA’s main goal is to better understand the drivers and human factors affecting certain relevant ways of cybercriminality, as well as empower and educate young people (children and teenagers primarily) in the benefits, risks and threats intrinsically linked to the use of the Internet by playing, thus preventing and mitigating cybercriminal behaviour.

Keywords: cybercrime,children,young,cyberbullying,grooming,trafficking,empowerment,education,serious game,online behaviour
Free-standing three-dimensional topological structures in geometrically confined chiral nematic liquid crystals: fundamentals and applications (TOPOZOO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

This two-year project aims at exploiting both the intrinsic robustness and wide diversity of topological structures that naturally appear in soft condensed matter systems such as liquid crystals in order to fabricate advanced materials, possibly reconfigurable, towards emerging photonics applications such as high-dimensional data storage and topological shaping of light at small scale. Our proposal basically relies on the use of geometrically confined chiral nematic liquid crystals that have been theoretically predicted to exhibit a rich variety of distinct metastable topological defects. Our ambition is to establish the related experimental foundations, to develop techniques for on-demand reconfiguration the generated topological structures, and to bring proof-of-principle of a few applications that we foresee. To this aim, the project will focus on one of the simplest case, namely the case of spherical microscopic droplets. The required scientific expertise and experimental facilities for successful completion of the project mainly cover the physics of liquid crystals defects, field-induced reorientation of liquid crystals and the topology of light fields. This will be ensured by the long-standing experience of the Supervisor as well as broad experimental capacities of the host group whereas present skills of the Researcher in the physics of liquid crystals and molecular photochemistry in confined media guarantee an efficient start of the project. Since the research topics of this proposal are encompassed in the global scientific policy of the host University, this project offers a unique opportunity to initiate perennial cooperation between the Researcher the host University. The successful implementation of the project will therefore be beneficial both to Supervisor’s research group and to Researcher’s career, who aims at obtaining a permanent position and eventually leading her own research group.

Keywords: liquid crystal defects,field induced reorientation of liquid crystals,light matter interaction,optical singularities
Elucidating the role of ultraviolet radiation in melanoma (MMUVR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2016-03-01
End date: 2021-02-28
Duration (months): 60.0
Total project cost (EUR): 2171622.89
EU funding (EUR): 2171622.89
Participants: 1
Project status: SIGNED

Melanoma incidence continues to increase across Europe and compared to other cancers, it disproportionately affects young people, causing a significant loss in life-years in those affected. Ultraviolet radiation (UVR) is the only environmental risk factor in melanoma, but the underlying genetic constitution of the individual also plays an important role. However, our knowledge of the gene-gene and gene-environment interactions in melanomagenesis is still very limited and here we will use various cutting-edge technologies to investigate the role of UVR in melanoma initiation and progression. We have developed mouse models of UVR-driven melanoma that closely mimic UVR-driven melanoma in humans and these provide an unprecedented opportunity to dissect how different wavelengths and patterns of UVR exposure affect melanomagenesis. We propose a multidisciplinary programme of work to examine how host genetic susceptibility factors and responses such as DNA damage repair and inflammation affect melanoma development and progression following UVR exposure. We will integrate knowledge from our animal experiments with epidemiological, histopathological, clinical, and genetic features of human tumours to improve stratification of human melanoma and thereby assist clinical management of this deadly disease. Our overarching aim is to develop a validated stratification approach to melanoma patients that will assist in the development of effective public health campaigns for individuals at risk across Europe.

Keywords: melanoma,host susceptibility,dna damage,infammation