Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mechanics of Nanoporous W under irradiation (MeNaWir)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

Fusion reactors demand materials capable of withstanding unprecedented extreme conditions. Refractory-based nanoporous metals offer a combination of mechanical and radiation performance that makes them ideal potential candidates for nuclear applications. Introducing a new material for this application requires characterizing its response under the extreme environment of fusion reactors; however, experimental testing facilities allowing to perform tests under these conditions are extremely limited. Modelling and simulation emerge as a valuable tool, allowing to replace many of such tests by simulations, and will become drivers in fusion materials development. The MeNaWir project aims at shedding light into elusive aspects of the mechanical behaviour of nanoporous refractory metals, focusing on nanoporous tungsten (np-W) and the effect of radiation damage on its mechanical properties. This will be accomplished by building a multiscale computational framework for the exploration of the mechanical properties of nanoporous metals for nuclear applications. This framework will encompass state-of-the-art modelling techniques from different fields, including Fast Fourier Transform – Crystal Plasticity simulations, radiation damage models and plasticity at the nanoscale. To achieve this goal, MeNaWir brings together a researcher with expertise in nanoporous metals and materials modelling at the atomistic scale with a world-recognized supervisor with expertise in modelling the non-linear behaviour and fracture of complex microstructures at the continuum scale and a research institute with a record of excellence, technology transfer, and top-level training in Materials Science. The specific objectives are to develop a framework for the computational assessment of nanoporous materials for the nuclear industry and to provide a window of optimal np-microstructures to guide the fabrication of np-W parts. MeNaWir could lastingly impact innovation on materials for fusion.

Keywords: nuclear materials nanoporous metals computational modeling computational homogenization crystal plasticity
Revolutionizing Skin Health with our Advanced Engineered Biotherapeutics (SkinEngineering)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain
Call: Transition Open 2024 (HORIZON-EIC-2024-TRANSITION-01, 2024)
Start date: 2025-05-01
End date: 2028-04-30
Duration (months): 36.0
Total project cost (EUR): 2499999.0
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

We have developed a ground-breaking patented technology that uses genetically engineered skin bacteria (C. acnes) to deliver biotherapeutics directly to the skin, offering safe, effective and long-lasting treatment for skin conditions such as acne. Our modified microbes continuously produce and secrete therapeutic molecules in the hair follicle, addressing the problems associated with invasive procedures and the poor transdermal penetration of traditional topical treatments. Preclinical results from our previous EIC Transition project SKINDEV (coordinated by UPF), have demonstrated significant efficacy in reducing sebum and inflammation in vitro. Additionally, further studies have shown successful engraftment and safety in mouse models. The SkinEngineering project will advance our technology from proof-of-concept (TRL3) to preclinical and regulatory validation (TRL5), bridging the gap between promising research outcomes and the stage where we are ready to enter into commercial agreements with potential partners. SkinEngineering will help us further refine our platform, complete preclinical studies and address regulatory and manufacturing aspects. We will also focus on ensuring the safety of our engineered bacteria, including robust biocontainment strategies. We have preliminarily validated the market fit of this effective and non-invasive therapy without adverse effects, confirming that it meets the needs of clinicians and patients in the €14 billion acne market. Our biotherapeutic also reduces the need for antimicrobial-based treatments, helping combat antimicrobial resistance, a key public health issue. Our commercialization pathway involves launching a spin-off, Synflora, with SkinEngineering refining our business model and go-to-market strategy. Successful project outcomes will capture the attention of key stakeholders, e.g., investors, pharma/cosmetic companies and end users, boosting our company’s awareness and enhancing its investment readiness.

Keywords: skin microbiome,genetic engineering,synthetic biology,acne,sebaceous glands,c acnes,cutibacterium acnes,engineered bacteria,engineered microbes
Human-centered Trustworthiness Optimisation in Hybrid Decision Support (THEMIS 5.0)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Italy,Belgium,Greece,Spain,Bulgaria,United Kingdom,Norway,Netherlands,Denmark,France
Call: AI for human empowerment (AI, Data and Robotics Partnership) (RIA) (HORIZON-CL4-2022-HUMAN-02, 2022)
Start date: 2023-10-01
End date: 2026-09-30
Duration (months): 36.0
Total project cost (EUR): 7075172.5
EU funding (EUR): 7075172.5
Participants: 18
Project status: SIGNED

THEMIS 5.0 draws researchers and practitioners from diverse disciplines in order to secure that AI-driven hybrid decision support is trustworthy and takes place in accordance with the particular human user needs and moral values as well as adhere with the key success indicators of the embedding socio-technical environment. It implements an AI-driven, human-centered Trustworthiness Optimisation Ecosystem that users can use to achieve fairness, transparency, and accountability. In THEMIS 5.0, the trustworthiness vulnerabilities of the AI-systems are determined using an AI-driven risk assessment approach, which, effectively, translates the directions given in the Trustworthy AI Act and relevant standards into technical implementations. THEMIS 5.0 will innovate in its consideration of the human perspective as well as the wider socio-technical systems’ perspective in the risk management-based trustworthiness evaluation. An innovative AI-driven conversational agent will productively engage humans in intelligent dialogues capable of driving the execution of continuous trustworthiness improvement cycles. THEMIS 5.0 adopts the European human-centric approach to the design, development, deployment and operation of the THEMIS 5.0 ecosystem and, in this respect, THEMIS 5.0 will base the implementation of its AI-driven ecosystem on strong co-creation processes. THEMIS 5.0 will pilot and evaluate the humancentric ecosystem using 3 well-defined use cases, each addressing a specific high priority and critical application and industrial sectors. The THEMIS 5.0 solution enhances and accelerates the shift towards more trusted AI-enabled services by unlocking the power of humans to evaluate the trustworthiness of AI solutions and provide feedback on how to improve the AI systems. Users can now better challenge AI systems, pinpoint any biases or problems, embed their own values and norms, and provide feedback to AI developers and providers for improvement.

Keywords: risk management,decision intelligence
Minimally invasive reliAble Glucose monitoring in Intensive Care (MAGIC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Norway
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-12-01
End date: 2025-01-31
Duration (months): 26.0
Total project cost (EUR): 5026500.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

9 of 10 intensive care unit (ICU) patients get elevated glucose levels because of their critical illness. Clinical trials prove that better glucose control could save thousands of lives and millions of euros for hospitals. Surprisingly, no continuous glucose monitor (CGM) is available for ICU patients, as solutions developed for diabetics don't work in the ICU. GlucoSet has a novel, patented technology for glucose monitoring. This enables - for the first time - reliable, minimally invasive, real-time monitoring of glucose in ICU patients. 4 of 5 EU ICU physicians say our product would be "very valuable" in their ICU and believe it will improve outcomes in their ICU. 9 of 10 ICU managers say they are willing to pay for use in a large share of their patients on launch. A demo version of the product has been tested in patients with excellent results (TRL6). This project aims to make the product ready for CE-mark (TRL8) in 25 months, then validate clinical benefits, and scale up (TRL9).
Boosting Institute of Chemistry, Technology and Metallurgy in Water Biomonitoring (BIOLAWEB)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Serbia,France,Norway
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 899410.0
EU funding (EUR): 899410.0
Participants: 3
Project status: SIGNED

BIOLAWEB aims at building a sustainable cooperation between the Institute of Chemistry, Technology and Metallurgy, University of Belgrade (UB-ICTM), and leading EU institutions – The French National Research Institute for Agriculture, Food and Environment (INRAE, France) and the Norwegian Institute for Water Research (NIVA, Norway), thereby strengthening the research and innovation capacity of UB-ICTM in biodiversity assessment and biomonitoring. BIOLAWEB will (1) bring UB-ICTM up to current standards with respect to methods that are currently applied across the European Union, and (2) apply newly emerging metabarcoding and eDNA technology to develop new and improved methods using eDNA. In order to strengthen research and innovation capacity, BIOLAWEB will establish a research management office at UB-ICTM to support project application, management and reporting at international level. Staff exchange, common field and laboratory work, and a variety of courses will be used for an effective knowledge transfer from the partnering institutions to UB-ICTM. Recently emerging technology will be implemented to develop new tools for water management, which will be useful across Europe. The methods developed in BIOLAWEB will pave the ground for further research and innovation in the assessment of biodiversity and ecological status. BIOLAWEB foresees that the methods developed during the project lifetime will later be applied in regular watercourse monitoring in Serbia and the region. The implementation of the BIOLAWEB results will raise the research profile of coordinator and partner institutions and contribute to UB-ICTM's vision of becoming a lighthouse for attracting the best talents and tackling the burning issues of environmental assessment.

Keywords: biomonitoring,indices for ecological status assessment,lakes,edna,diatoms,phytoplankton,a research management office
Leveraging Social Acceptance and Behavioral Insights for Adaptive Opaque Facade Technologies in Zero-Carbon Buildings (NOVA ZERAF) (NOVA ZERAF)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Italy,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 21.0
Total project cost (EUR): 486500.0
EU funding (EUR): 486500.0
Participants: 2
Project status: CLOSED

The success of adaptive opaque facade technologies in achieving zero-carbon buildings across Europe depends on addressing the social dynamics influencing their adoption. The primary aim of the NOVA ZERAF project is to expand and deepen scientific understanding of the drivers and barriers impacting ZERAF technologies at both decision-making and end-user levels. To achieve this, Universidade Nova de Lisboa (NOVA) will support and collaborate in the Horizon Europe ZERAF project, identifying the factors that promote widespread acceptance of innovative opaque facades technologies. NOVA will use a mixed-methods approach, employing structural equation modelling to analyze the social drivers and barriers affecting acceptance of adaptive opaque facade technologies. This research will offer critical insights into the enablers necessary for the successful implementation of ZERAF technologies across diverse European contexts. NOVA’s involvement promotes knowledge exchange and builds capabilities among the ZERAF project participants, enhancing the competitiveness of the research and innovation system and fostering the adoption of adaptive facades. This partnership will contribute to the expected outcomes of the ZERAF project by integrating social analysis with advanced methodologies, amplifying the project's impact on sustainable building solutions. Additionally, this proposal aligns with the expected impacts of the Hop On Facility call by strengthening collaboration and knowledge sharing between NOVA and consortium partners, mobilizing expertise and enhancing NOVA's role as a widening partner.

Keywords: user acceptance and behavior change user engagement impact assessment structural equation modelling building smart materials
Support stakeholders fora on geothermal systems (GEOTHERM-FORA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Coordination and support actions
Countries involved: Belgium,Germany,Italy,Iceland,Netherlands
Call: Support to the activities of the ETIPs and technology areas of the SET Plan (HORIZON-CL5-2021-D3-02, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 999546.25
EU funding (EUR): 999546.25
Participants: 7
Project status: SIGNED

In order to decarbonise the power, heating, and transport sectors and reach a climate neutrality by 2050, Europe needs a wide range of renewable technologies, including geothermal systems. Geothermal will be a key energy source in the European decarbonized energy mix. Indeed, geothermal is a unique energy source that can provide a significant share of electricity, heating and cooling, thermal storage and minerals such as lithium in 2022 and beyond. It is a source of energy which is renewable, local and continuously available as it is not dependent on climate conditions. Europe has pioneered the exploitation of geothermal resources for over a century and the EU still maintains a leading role due to research, innovation and the development of new technologies allowing the production of geothermal power as well as heating and cooling everywhere. In this proposal, the project GEOTHERM-FORA aims at facilitating Research and Innovation (R&I) activities in geothermal systems by supporting the workResearch, development, and innovation (RD&I) are needed to develop renewable technologies, accompanied by market uptake measures. Major investments in geothermal research and innovation are necessary to develop and deploy the next generation of geothermal technologies and answering the challenges for the transformation of our energy system towards a decarbonisation of our economy. Research, development, and innovation (RD&I) are needed to develop renewable technologies, accompanied by market uptake measures. Major investments in geothermal research and innovation are necessary to develop and deploy the next generation of geothermal technologies and to answer the challenges for the transformation of our energy system towards a decarbonisation of our economy.

Keywords: geothermal,set plan iwg,etip,research and innovation,competitveness
Projection of Security Vulnerabilities caused by Exploits in Dependencies (ProSVED)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-21
End date: 2024-06-20
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: CLOSED

ProSVED stands for Projection of Security Vulnerabilities caused by Exploits in Dependencies, and targets the prognosis of software vulnerabilities via security exploits in third-party libraries. The code controlled by developers, e.g. to add security patches, is a small fraction of the whole codebase that supports any software project today. Most lines of code reside in external dependencies whose security vulnerabilities pose threats to the entire project. This can be mitigated via strategic update policies. However, measuring the risks to find optimal policies constitutes a tremendous prognosis problem, to find the needle of offending lines that hide in a haystack of third-party libraries. ProSVED proposes a novel rare-event approach to the challenge, to estimate the most promising update policies in order to reduce the security risks inherited from external code. Working with experts from the University of Trento, ProSVED will thus push the frontiers of software security analysis, taking it beyond its classical empirical approach, and into the horizon of formal risk modelling for prediction and mitigation.

Keywords: rare event simulation,risk prognosis,cybersecurity,library dependencies
A Palaeoenvironmental Investigation of Amazonian Lowland Sensitivity to Climatic Drivers Using Pollen-based Modelling Approaches (PALOMA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: SIGNED

The Amazon is one of the world’s most biodiverse ecosystems and our greatest carbon-sink, but human activity and climate change are posing severe threats to its existence. We are still a long way away from knowing how sensitive plants in the Amazon really are to variations in temperature and precipitation. One way we can understand this is by looking at fossil pollen accumulated over thousands of years, which can be used to reconstruct what the forests looked like over time and how they changed. In the context of Amazonia, so far there hasn’t been a way to connect changes in the pollen assemblages with climatic events because the forests in this region are diverse and many areas respond differently to environmental factors, and there is not enough data to allow comparisons between sites. To understand the sensitivity of Amazonia to climate change, we aim to use pollen-based modelling to reconstruct changes in temperature, precipitation and seasonality in the lowlands of Ecuador and Peru. This will be achieved by collecting modern pollen samples and gathering other existing datasets from collaborators, as well as modern climate data recovered from meteorological stations. We will use these datasets to calibrate key existing fossil pollen records from the region thereby enabling the reconstruction of palaeoclimatic parameters through the use of ‘transfer functions’. By improving our database of modern pollen for the lowlands of Amazonia and applying novel modelling techniques, we aim to provide new knowledge about ecological tipping points, plant responses to abrupt changes, effects on population abundance and structure and lags in response to climate. This project represents a key advancement not only to the field of tropical palaeoecology, shedding light on the response of vegetation dynamics to climate change for a region where this is still so mysterious, but it also represents a major contribution to the conservation of a globally important biome.

Keywords: amazon,calibration,forest sensitivity,palynology,transfer functions,gams