Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Investigating the Role of the Unfolded Protein Response as a Novel Targetable Pathway in BRAF Mutant Colorectal Cancer (UNBRACE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-01
End date: 2021-01-31
Duration (months): 24.0
Total project cost (EUR): 187866.0
EU funding (EUR): 187866.0
Participants: 1
Project status: CLOSED

BRAF mutant (MT) colorectal cancer (CRC) accounts for 10-15% of CRC and represents the subgroup with the worst overall survival. There is an urgent need to identify strategies that hit the 'Achilles Heel' in poor prognostic BRAFMT CRC. Preliminary data from the host lab have shown that BRAFMT CRC cells are vulnerable to disturbances in the Endoplasmic Reticulum (ER)-specific Unfolded Protein Response (UPR) machinery. The overall aim of the proposal is to identify whether the ER stress activator ONC201 in combination with MAPKi (MEK1/2i or BRAFi) will be a novel treatment strategy for BRAFMT CRC. Specific objectives of the proposal are 1. Investigate the effect of ONC201 combined with MAPKi in BRAFMT CRC in vitro. 2. Investigate the in vivo effect of ONC201 with MAPKi using BRAFMT CRC syngeneic and patient derived xenograft models. 3. Assess prognostic/predictive role of ER stress proteins in CRC. UNBRACE will go beyond the current state-of-the-art by (i) developing a novel treatment strategy targeting the biology of poor prognostic BRAFMT CRC; (ii) using relevant pre-clinical models and clinical available datasets to underpin a novel stratified solution for BRAFMT CRC with poor clinical outcome. UNBRACE adopts the concept “personalized medicine strategy” through applying a novel approach targeting BRAFMT CRC. This fellowship will provide the researcher, through mobility, an increased set of excellent skills (e.g. molecular pathology; patient derived xenografts, 3D organoids), which will give him the opportunity to become a future leader in experimental cancer medicine. The fellowship will result in a strong collaborative network between the host and partner institute, transfer of knowledge between academia and industry, ultimately resulting in a phase I clinical trial in BRAFMT CRC. The fellowship can form the basis to attract other scientists internationally, from other disciplines and sectors to receive training in these unique R&I skills.

Keywords: colorectal cancer,oncogenic braf,unfolded protein response,in vivo models
Towards comprehensive maps of tree structure and function: linking tree architecture, anatomy and physiology (treeMAAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-14
End date: 2023-04-13
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: CLOSED

There is a striking diversity of tree architectural and anatomical forms worldwide. The functional meaning of several conspicuous architectural and anatomical spectra, and their costs and benefits remain obscure. For example, it is unknown why some tree stems are composed of large portions of living cells while others are mainly built of dead cells. Moreover, we do not understand how architecture and anatomy are coordinated. Better comprehension of these two types of structural variation is critical because they both govern tree resource acquisition, distribution and usage, as well as mechanical stability. These processes, in turn, affect tree competitive ability and reproductive success. Ultimately, tree structural strategies shape forest structure and function, and its response to current and future climate. Our present understanding of tree architecture hinge on theory and models due to a lack of architecture data, but recent advances in terrestrial laser scanning methods allow quick and precise measurements of tree architecture. Seizing this technological opportunity, treeMAAP will quantify architectural, anatomical and physiological traits to assess how they govern three major functions: water transport, mechanical stability and respiration. 15 diverse tropical tree species will be studied. TreeMAAP main objectives are: 1) to determine how anatomy and architecture coordinate to achieve a given functional outcome, and 2) to examine how water transport efficiency, mechanical stability and respiration rates trade-off at the local, organ and whole-tree level. By integrating architecture, anatomy and physiology, treeMAAP will provide entirely new perspective on tree structural diversity and its functional implications. The new knowledge will advance functional wood anatomy, functional ecology, physiology and vegetation modelling and will likely stimulate fresh and innovative research directions.

Keywords: plant ecology,structure and function,tree architecture,wood anatomy,functional traits,respiration,functional ecology,tropical forests,biomass,terrestrial laser scanning
Let restore our soils : using the soil food web to engineer the soil structure and functionning (AGG-REST-WEB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2020-07-11
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Rationale: Soils are precious for human health and food production but 33 % of the world soils are degraded. Developing ecological engineering strategies to restore them is an urgent need. Soil structure is a key aspect of soil functioning, with soil aggregates being organo-mineral associations, constituting its building bricks. The influence of soil organisms on soil aggregation is commonly acknowledged but supported by little direct mechanistic evidence, which are mainly single group approaches, hence not depicting the role of the complex soil biota. Aim: The aim of this MSC project is to directly link the soil food web properties to the formation of soil aggregates, with subsequent consequences on the restoration of soil functioning. The novelty of this project is that it will provide direct mechanistic evidence of how species interactions – and not only diversity – can influence a key soil process: the formation of aggregates. The resulting knowledge will provide basis for developing soil ecological engineering techniques to restore degraded soil via soil biota manipulation. Methodology: Unravelling such mechanistic understanding will require a multidisciplinary approach merging soil animal ecology and soil physics. The project will be hosted by the University of Göttingen in Germany, providing unique access to soil ecology and physics lab facilities. Two experiments, respectively manipulating targeted trophic interactions (bacteria-amoebe and fungi-collembola) and natural soil food web complexity (tracked by isotope tracing, PLFA, etc.) will be run in microcosms and mesocosms, and resulting changes in soil aggregate properties and soil functioning will be assessed by cutting edge physics techniques, such as neutron radiography and X-rays tomography. A secondment period in the Freie University of Berlin will allow the fellow to reach a functional understanding of the effect of soil biota on aggregation through the measurement of soil organismal traits.

Keywords: soil ecological engineering,soil ecology,soil biodiversity,soil physics,soil aggregate,soil food web,soil hydraulics,ecosystem functioning,ecological restoration,trait based approach,protist
EU Training Network on Novel Targets and Methods in Atrial Fibrillation (AFib-TrainNet)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Israel,Austria,Switzerland,Norway,Netherlands,United Kingdom,United Kingdom,Denmark,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2015-09-01
End date: 2019-08-31
Duration (months): 48.0
Total project cost (EUR): 4101221.52
EU funding (EUR): 4101221.52
Participants: 11
Project status: CLOSED

The AFib-TrainNet consortium will enable promising young scientists to become excellent research leaders of the future, capable of fighting the challenges that Atrial Fibrillation (AF) presents to the European population. AF is the most common sustained cardiac arrhythmia, occurring in between 1-2% of the general population. More than 6 million Europeans suffer from this arrhythmia and its prevalence is expected to increase by more than two-fold during the next 40 years due to increased life expectancy. Thus, AF is said to assume epidemic proportions. Current options for pharmacological therapy are limited by both low efficacy and side effects, including life‐threatening ventricular arrhythmias and severe extra-cardiac toxicities. A very limited number of novel AF drug therapies have been introduced in the last 20 years. This imbalance reflects a gap in understanding in both how AF develops and how it can be treated, which thereby limits the development of new medicines. Our ambition with the AFib-TrainNet is to fill this gap by producing new knowledge, leading to critical insight into origins and mechanisms of sustenance of atrial fibrillation. We will accomplish this by developing novel experimental and computational models recapitulating human AF, and employing these models on two very promising atrial biological targets. Experimental models will be instrumental in improving the understanding AF’s underlying mechanisms, and will, along with clinical data, inform state-of-the-art computational models of human atrial electrophysiology. These new tools will permit fresh insight into the molecular, cellular and electrical mechanisms involved in the progression of healthy atria into an AF state. Our endeavor will deliver results which can be leveraged by the pharmaceutical industry to target AF drug development, and the work accomplished in AFib-TrainNet will thus constitute a beacon in the search for new AF medicine.

Keywords: atrial fibrillation,novel therapeutic targets,ion channel,electrophysiology,pharmacology,physiology,computational simulation,ipscs,translational research,research training
The Importance of Barriers to Bird Migration (BIRDBARRIER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Understanding animal migration is one of the most compelling and challenging problems of modern biology. For a long time, we have been hindered by the large geographical scale of migratory movements and the small sizes of most migratory animals. Crossing barriers is a fundamental aspect of animal migration. Long-distance migratory birds face crossings of formidable barriers such as the Sahara Desert, Himalaya Mountains, or the Pacific Ocean twice a year, but even short-distance migrants travel across inhospitable habitats. Successful migration, and specifically successful barrier crossings, depend on the availability of favourable weather conditions aloft and suitable habitat during stopovers. Surprisingly little is known about the behaviours that guide billions of avian migrants to a successful barrier crossing. Advances in tracking technology and remote sensing now offer us new tools to track small migratory animals with extraordinary precision. I will use these new methods to study how nocturnally migrating songbirds manage barriers during their migration. With this action I aim to increase the understanding of (1) the behavioural strategies that birds use to negotiate large geographic features and (2) how barriers limit bird migration. The research will be conducted under PI Prof. Kasper Thorup in the Bird Migration Lab, Center for Macroecology, Evolution and Climate, at the University of Copenhagen. Prof. Thorup’s group has advanced the front of global scale tracking of avian migration for the last decade, and possess the necessary expertise in spatiotemporal patterns. Further, I will spend a secondment at the Institute of Avian Research, Germany, and gain from Dr. Heiko Schmaljohann expertise in stopover behaviour. By combining my existing expertise in radiotelemetry tracking and migratory behaviour, with new skills in additional tracking techniques and analytic tools, this action will advance the research field and enhance my career as independent researcher.

Keywords: migration,songbirds,ecological barrier,behaviour
Neurodevelopmental outcome in offspring conceived by parents at advanced parental age (NeuroAPA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-07-31
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: CLOSED

In current society, a growing number of individuals is affected by mental disorders, thus representing a burden with significant health, social and economic consequences. Notwithstanding, the ethiology of mental disorders is still not fully understood, there is a growing evidence that current trend to delay first childbirth above age of 35 is a factor of risk for the onset of mental disorders (i.e. autism, schizophrenia) in resulting offspring. This “new” reproductive trend, caused by social and economic factors, has already allowed the birth of millions of babies worldwide. In the last decade, epidemiological studies have suggested that children conceived at advanced maternal age are at higher risk of autism spectrum disorders as well as psychotic and/or bipolar disorder and those conceived at advanced paternal age at higher risk of autism and schizophrenia. However, data from population-based investigation are often controversial, due to several confounding factors (i.e. health, socio-economic status, lifestyle), and information from animal studies are still limited. In this context, the assessment of neurological and/or psychiatric health of offspring conceived at advanced parental age (APA) is urgently needed. Moreover, understanding the mechanism(s) behind increased risk of mental affliction (i.e. autism and/or schizophrenia) will contribute to the identification of novel marker for neurologic/psychiatric disorders with a significant impact on basic science, society and health care services.“NeuroAPA” aims to identify structural and functional abnormalities in adult brain which may contribute to the increased risk of psychiatric disorders (i.e. autism, schizophrenia) in offspring conceived by parents at advanced parental age.

Keywords: advanced parental age apa,psychiatric disorders i e autism,schizophrenia in offspring,mouse models
Illes Balears INNOvation Management Services (IBINNO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Spain
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 12724.0
EU funding (EUR): 12724.0
Participants: 3
Project status: CLOSED

The overall IBINNO project objective is the establishment of a feasible and effective service for enhancing the innovation management capacity of SMEs in the Balearic Islands region. This will benefit the smart growth in the European Union by increasing the efficiency and effectiveness of investments in research, development and innovation and by contributing to a better and more efficient connection of stakeholders in the innovation fabric. The work is plan based on two work packages conducted for the two types of service that will be offered to two different groups of companies: • Beneficiaries of the SME Instrument, FTI and FET-Open. • SMEs with significant innovation activities and/ or a high potential for internationalisation. IBINNO H2020 envisages a reinforced link with the B2EN COSME, and by combining both programme support, the B2EN Consortium in the Balearic Islands will become a one-stop-shop for business and innovation support along the entire value chain. The Consortium will integrate both H2020 and COSME programme activities implementing a common client-centric approach on a “hub and spoke model” structure and applying the Network client journey when necessary. IBINNO will act as access point to the innovation and internationalization system in the Balearic Islands region, which will be in this new period covered by Balearic Islands Enterprise Network B2EN consortium, embedding the EEN innovation services in the regional innovation ecosystem.

Keywords: innovation management,growth,internationalization,capacity building,sme instrument,fet open
A highly efficient intelligent industrial microwave heating system based on high power solid state technology (CLEAN-HEAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Germany,United Kingdom
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-2-2014, 2014)
Start date: 2015-06-01
End date: 2017-08-31
Duration (months): 27.0
Total project cost (EUR): 1390221.5
EU funding (EUR): 973155.05
Participants: 2
Project status: CLOSED

Magnetrons are the most widely used microwave technology today for both industrial and domestic microwaves. But these systems can only achieve efficiencies of around 45 to 50%, pose safety risks as the use high voltages (5kV) and the magnetrons have a short lifespan requiring frequent replacement. Magnetron technology does not allow for the automatic adjustment of power level to match the load variations. These limitations have a huge cost to industrial microwave processes and there are calls for more efficient solutions. Across Europe, microwaves consume over 9.6 TWh of electrical energy annually. F&M seeks to upscale its 200W solid state continuous wave microwave system to address these limitations. The 1kW gallium nitride based microwave system will save at least 25% on electricity consumption, operate at more than 70% efficiency, allow automatic adjustment of power level in response to load variations and significantly reduce equipment size. It will also provide increased lifespan eliminating the need for frequent and costly replacements. With all these excellent features and performance advantages, our product also comes at a very competitive cost to the user which lies in the same range with the magnetron systems. Solid state microwave technology can be used in moisture meters, medical applications like RF-Surgery, and microwave ovens for the manufacture of electronic assemblies. It also offers opportunity for automatic power matching that enhances energy efficiency and faster processing speeds. Full adoption of our technology in both domestic and industrial microwave ovens would lead to potential energy savings of 6.74TWh of electrical power across Europe.

Keywords: microwave ovens,solid state,efficiency,thermal management,industrial processing
STADY: Autonomous intelligent cleaning robot for stables (STADY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Founded in 2012 in Germany, Perpetual Mobile provides Mobile Application and consulting services in farm management and machinery control. Our 14 engineers, ICT and business managers have completed over 150 projects to date. Our familiarity with the market needs led us to develop new navigation technology called outside-in tracking (patented) that is the core of Zauberzeug™, a robot for the autonomous cleaning of stables. EU stables currently produce 1.38 million tonnes of manure annually that must be cleaned to avoid public health and pollution issues and comply with the Waste Framework Directive 2008/98/EC. Cleaning staff is difficult to source and expensive (around €27,500 per year). Current navigation technologies are based mainly on expensive GPS, LIDAR or Magnetic fields which allow navigation only outdoors or indoor and only over a limited variety of floor surfaces, preventing their use in livestock facilities or stables. However, the outside in tracking technology of Zauberzeug™ (combination of robot, a set of microprocessor cameras and a Mobile App) can automatically navigate both indoors and outdoors to detect, pick up and deposit objects (waste) with high precision. Our business model is also unique. Zauberzeug™ is offered for free, it has minimum installation and maintenance requirements (predictive maintenance). We will be the first movers offering advanced robotic Cleaning as a Service. Customers will acquire Zauberzeug™ free of charge and they will pay only for the cleaning service. This way we reduce the annual cleaning costs for stable owners (our customers) by up to 56%, while boosting our company growth. With a 250 units/year capacity by 2021, and a total potential market of stables having an area of 110Million square meters, our goal in the short term is to offer Zauberzeug™ services to an area of 1 million square meters of horse stables in Europe, generating €17 million profits and 16 new job positions, as forecasted for the period 2021-2025.

Keywords: autonomous cleaning,indoor,outdoor navigation technology,robots,farm stables