Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Targeting Type 2 Diabetes with Allene-containing Molecules Using a C-N Bond Cleavage Tool (ALLENEDRUG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-07-01
End date: 2026-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Type 2 Diabetes is a chronic disease affecting more than 450 million people world-wide and is still an unmet medical need. PPAR´s (Peroxisome Proliferator-Activated Receptors) and G-protein-coupled receptors (GPCR) FFARs (Free Fatty Acid Receptors) are well clinical validated targets for type-2 diabetes. Although selective GPR40 agonists have reached clinical phase III, the trials were recently terminated due to signs of liver toxicity in patients. ALLENEDRUG is designed to provide a new chemical series of GPR40 ligands aiming to bring a safer type-2 diabetes therapy. To achieve this goal, we will use a synthetic tool developed in our laboratory to prepare enantiomerically enriched allenes through a selective C-N bond cleavage. This ERC-PoC will allow us to test the new chemical series as potential GPR40 agonists and to get insight into a SAR (Structure Activity Relationship) correlation with liver toxicity in order to compare the new molecules prepared in this proposal with those currently in clinical phase III trials.
3D Printing of Pyrolytic and Graphitic Carbon (3D-Carbon)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

3D printing of carbon materials has significantly impacted several research fields, including energy, electronics, transport, health, and space. Particularly in tissue engineering applications, it promises the fabrication of patient-specific personalized scaffolds, offering a suitable combination of essential properties. However, several challenges remain in the marriage of 3D printing and carbon materials. Two of the current challenges are little control in the properties of 3D printed pyrolytic carbon (3DPyC) and the complex fabrication process of 3D graphitized carbon (3DGC). Therefore, even though preliminary studies show good cytocompatibility of 3DPyC and 3DGC, a proper investigation of the cell-carbon interaction, essential for tissue engineering applications, cannot be reliably performed. The 3D-Carbon project aims to solve these two challenges by developing a pathway to reliably control the micro and macro-structural properties of 3DPyC and introducing a facile fabrication approach for 3DGC. These will be achieved through synthesizing customizable functionalized green precursor materials suitable for stereolithographic 3D printing and controlled pyrolysis. Cell culturing within 3D printed carbon scaffolds with controlled properties will further allow us to have a better understanding of the cell-carbon interaction, which could, therefore, lastingly impact innovation on carbon scaffolds for tissue engineering applications. Furthermore, such a study will lead us to the future development of carbon-based engineered living materials.

Keywords: carbon,3d printing,pyrolysis
Innovative approaches to implantation research in health and disease (IMPLANTEU)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Austria,Belgium,Italy,Netherlands,Ireland,Germany,France
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 3875439.09
EU funding (EUR): 3432420.0
Participants: 15
Project status: SIGNED

Implantation of the embryo in a receptive uterus is critical for mammalian reproduction, yet remains poorly understood. This challenge is particularly significant in human health, as up to two-thirds of human pregnancies are lost due implantation failure. In the agricultural sector, particularly in sustainable milk and meat production, understanding and improving embryo implantation is equally crucial. High peri-implantation mortality rates in livestock lead to lower efficiency, profitability, and environmental sustainability. Much remains unknown about the molecular pathways and regulatory mechanisms of embryo-endometrial interactions in humans and livestock species. For ethical and practical reasons, implantation cannot be adequately studied in vivo in human, and it remains challenging in most animal models. IMPLANTEU is an international community of researchers whose objectives are: 1) To develop a molecular blueprint of human implantation in health and disease; 2) To improve implantation fitness for food production mammals and 3) To develop an advanced toolkit for implantation research. IMPLANTEU provides multi-species, multi-sector and multi-model molecular and system implantation research, integrating complementary expertise in reproductive and stem cells biology, medicine, physiology, ethics and law, and cutting-edge technologies such as stem cell-based embryo models, organoids, machine learning, and organ-on-chip. IMPLANTEU will train 13 doctoral candidates through research, innovation, secondments in academic and industrial environments, horizontal and focused courses, and interactions with stakeholders. The findings generated through IMPLANTEU will contribute to the profound understanding of the embryonic and endometrial contribution to reproductive success, innovations in infertility treatment, animal production efficiency and sustainability, tissue bioengineering, pathogen-host interaction, reproductive toxicology, and stem cell biology.

Keywords: implantation,embryo mosaicism,food production,ethics and law
Photo-rechargeable Zinc-ion Battery for the Internet of Things Working under Ambient Light (Photo-IoT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

By 2025 more than 49 billion Internet of Things (IoTs) are anticipated due to technological breakthroughs and its widespread application in smart homes, smart cities, agriculture, health sector, and industry. However, supplying power to this enormous number of IoT devices is challenging. Accordingly, an autonomous power source operating for multiple years is indispensable to run this massive number of IoTs and portable electronic devices. Photo-rechargeable batteries harvest and storage energy in a single device, and have grown huge attention as an autonomous power source in recent years. In this project, we will develop dye-sensitized photo-rechargeable zinc-ion batteries, which can work under ambient light (artificial indoor and outdoor diffuse light) and could be an autonomous power source for IoTs and low-power-consuming portable electronic devices. This project focuses on the development of the vanadium-based high entropy oxide cathodes for rechargeable zinc-ion batteries (ZIBs) and its integration with a high opencircuit voltage Cu-electrolyte based dye-sensitized solar cells (DSSCs). DSSCs are recognised for their cost-effectiveness, environmentally friendly nature, and simple fabrication process, surpassing power conversion efficiency by over 38.0% under indoor lighting conditions. Concurrently, ZIBs offer an environmentally friendly and more manageable alternative to non-aqueous rechargeable batteries, simplifying fabrication and further cutting costs. Furthermore, ZIBs have a compatible voltage window with the DSSCs. Therefore, integrating DSSCs with aqueous ZIBs is a feasible technique as an autonomous power source that can be both cost-effective and environmentally friendly. The project aims to revolutionise the field of green energy by fostering the rapid advancement of photorechargeable batteries that are more sustainable and efficient.

Keywords: photorechargeable batteries,solar batteries,zinc ion batteries,internet of things iots,ambient light,photo iot,high entropy oxides
Distributional Effects of Environmental Policies (DEEP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Norway
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

A key goal of environmental policy is to ensure sustainable choices and investment. For the individual, revising choices and behavior might be necessary to avoid costs or obtain benefits introduced by policies. Though a growing literature has investigated how different environmental policies produce winners and losers through differences in costs and benefits between individuals, less is known about the causes of varying adaption to new policies. In the context of environmental policy, there are no studies of how the "hand of the past" determines the ability to adapt through choices that are not easily reversed, such as location, and exposure to wealth effects from revaluation through existing endowments at the individual or firm level. The goal of DEEP is to provide new knowledge of how existing differences interact with environmental policies in shaping choices, with consequences for policy effectiveness and the evolution of disparities among households and firms. The key to achieve this is the construction of novel and exceptionally ambitious models of decisions that affect outcomes over time, combined with data of unparalleled detail on choices, outcomes, income and assets of individuals, households and firms in settings featuring rich and highly relevant policy interventions. The results will contribute both to our understanding of how inequality develops under policy choices in interaction with preexisting disparities, and our understanding of the trade-offs between equity and effectiveness when designing policies. The project will center on two strategically important areas: 1) electrification of transportation, where existing vehicle, location and wealth of households influence policy impact, with implications for wealth and welfare over time; and 2) renewable energy subsidies, where existing capacities of firms influence policy impact on investments and capacity decisions, with implications for the evolution of market structure and market power.
Reliable Medical Grade Home-Based Test for Self-Use for people with Sleep DIsorders (S-trodes)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-11-01
End date: 2025-10-31
Duration (months): 24.0
Total project cost (EUR): 3672500.0
EU funding (EUR): 2457113.75
Participants: 1
Project status: SIGNED

Sleep disorders are prevalent in 1/3 of the global population, across various age groups, and considered a public health epidemic. Nevertheless, sleep disorders are often unrecognized and under-reported. These disorders can contribute to other medical problems, and some may also be symptoms for underlying mental health issues. Sleep monitoring is essential for reliable diagnosis and improved management of sleep disorders. Currently, sleep disorders are only measured during an overnight Polysomnography (PSG); however, this method is limited in clinical implication due its unavailability, high cost, unnatural sleep environment and episodic brain patterns. Smart Skin technology enables monitoring treatment efficacy: the platform is designed to replace PSG with home-based accessible technology. The EIC funding will enable X-trodes to optimize its platform and to perform the clinical validation activities necessary to obtain CE Mark and start commercialization in Europe.

Keywords: parkinson s disease,sleep disorders,brain monitoring,electrodes,printed electrodes,brain waves,sleep monitoring,sleep architecture,wellbeing
Optimizing Polyhydroxyalkanoate Production Through Macro and Molecular Insights in Mixed Microbial Cultures (SalinePHA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 191343.12
EU funding (EUR): 191343.12
Participants: 1
Project status: TERMINATED

Plastic waste is a significant global environmental challenge due to its environmental persistence and the threat that microplastic poses on living organism. Polyhydroxyalkanoates (PHAs) are biopolymers produced by prokaryotes under availability of excess carbon but unfavorable growth conditions. Interestingly, certain types of stress conditions have been proven to increase PHA production in axenic cultures such as oxidative stress or osmotic upshock. PHA stands as one of the main alternatives to traditional plastics as they are biodegradable under a wide range of conditions, but high production cost hampers its wide adoption. Current technologies are based on the use of mixed microbial cultures (MMCs) in open bioreactors feed with industrial by-products to reduce the production cost. However, the PHA productivity using these approaches is low compared to axenic cultures growing on defined media. SalinePHA aims to enhance PHA productivity in bioreactors by using halophilic MMCs. Availability of metagenomic and transcriptomic techniques provides a great opportunity to study the genetic regulation of the PHA synthesis/depolymerization and potential shifts of the metabolism in complex microbial communities under different types of stress. To achieve this, i) halophilic PHA-accumulating MMCs will be obtained by growing environmental inocula under selective pressure and, characterized (performance parameters and shotgun metagenomic sequencing); ii) RNA-seq, RT-PCR, 2D-DIGE experiments will be performed on the best PHA-accumulating MMC under various stress conditions to understand the PHA metabolic regulation. A deeper understanding of the PHA accumulation dynamics will allow for the design of operational parameters by using stress conditions as elicitors to induce high PHA-accumulation in the bioreactor to obtain increased PHA productivity, reducing the cost of its production, allowing the valorization of organic saline waste streams and reducing the use of fresh water.

Keywords: pha,microbial mixed cultures,halophile,saline waste stream valorization
Agile Manufacturing as a Service through AI Autonomous Agents (MaaSAI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Greece,Spain,Portugal,Finland,Italy,Germany,Belgium,Poland,Bulgaria
Call: Manufacturing as a Service: Technologies for customised, flexible, and decentralised production on demand (Made in Europe Partnership) (RIA) (HORIZON-CL4-2024-TWIN-TRANSITION-01, 2024)
Start date: 2024-12-01
End date: 2027-11-30
Duration (months): 36.0
Total project cost (EUR): 8104010.33
EU funding (EUR): 6999228.37
Participants: 21
Project status: SIGNED

The goal of the project is the creation of the MaaSAI System, a comprehensive digital system to automate and facilitate interactions between suppliers of manufacturing systems (Providers) and manufacturing companies (Consumers) in a Manufacturing-as-a-Service (MaaS) ecosystem, in an agile, efficient and transparent manner. The MaaSAI System aims to revolutionise manufacturing and remanufacturing processes by facilitating access to flexible and decentralised capacities, through the MaaS business model, that extends the principles of the service-oriented economy to the manufacturing industry. The MaaSAI System aims to contribute to the reduction of the heavy investments that manufacturers have traditionally had to make to set up and maintain their operations. With an emphasis on production flexibility, agility and responsiveness, the MaaSAI System enables on-demand sustainable manufacturing, optimising resource utilisation, facilitating the transition towards circular facilities, and promoting better integration of the value chain. The MaaSAI project leverages on Explainable Artificial Intelligence (xAI) in autonomous agents to negotiate the use of manufacturing capacities between providers and consumers in a dynamic MaaS ecosystem. The incorporation of secure, and real-time data exchange between participating companies ensures fast response times and improves collaboration. The MaaSAI System represents a paradigm shift that enables manufacturers to access and utilise on-demand production capabilities, further increasing efficiency and lowering barriers to entry for SMEs. The MaaSAI project will deploy 3 main key exploitable results: 1) MaaSAI Cloud MaaS Marketplace; 2) MaaSAI Provider Suite; 3) MaaSAI. The MaaSAI System will be demonstrated in 5 Pilots of European companies from different sectors: metal machining, gears and mechanical power transmission, biomaterials, food processing, and electronics manufacturing.

Keywords: cloud marketplace collaborative hub autonomous agents digital twins digital industrial passport blockchain secure messaging optimisation and simulation
Interneurons GATing of aversivE or rewarding information from the basolateral amygdala to ventral hippocampus. (InGATE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-02-16
End date: 2027-02-15
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

The ability of neuronal networks to process and store information relies on the activity of diverse subclasses of inhibitory interneurons (INs). While the importance of inhibition in controlling key features of network function is being increasingly appreciated, the understanding of the role of INs in neuronal networks function is limited by the incomplete knowledge of the connectivity between the different IN subclasses and pyramidal cells. Such gap of knowledge is even more evident when considering the connectivity between INs and engram cells, i.e. subgroups of pyramidal neurons encoding specific memories. In this conceptual framework, the InGATE project will analyze specific amygdalo-hippocampal circuits involved in valence coding, where memories of stimuli imbued with negative or positive valence segregate in different engram cells in the BLA. InGATE will test the hypothesis that two broad INs subclasses, the parvalbumin (PV) and somatostatin (SST) expressing INs, differentially gate aversive or rewarding information from the BLA to the CA1 region of the ventral hippocampus. To this end, I will analyze the functional connectivity between BLA aversive or rewarding engram cells (formed during fear or reward conditioning) to pyramidal cells and PV/SST interneurons in vCA1. In parallel, I will study vCA3 Schaffer collaterals converging on those vCA1 pyramidal cells and PV/SST interneurons that receive inputs from the BLA aversive or rewarding engram cells. Thus, the ultimate goal of InGATE is to clarify how PV or SST interneurons shape engram cells in vCA1 by integrating valence-related information from BLA and multisensory contextual information from the vCA3 area. InGATE will combine several state-of-the-art methodological approaches to generate, identify and manipulate aversive or rewarding BLA engrams and isolate their targets in vCA1. In addition, it will exploit an in vivo approach to measure population activity of excitatory and inhibitory neurons in vCA1.

Keywords: gabaergic inhibition,inhibitory engrams,egrasp,ventral hippocampus,associative memory
Fair Competition in App Markets (APPMARKETS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1491849.0
EU funding (EUR): 1491849.0
Participants: 2
Project status: SIGNED

App markets—such as Apple’s App Store or Google Play—have significant economic importance and drive digital innovation. In 2021, the App Store alone facilitated transactions worth over EUR 511 Bn, which equals the GDP of Sweden. However, app market operators have also attracted severe scrutiny from regulators due to their integrated gatekeeper structure: they operate a marketplace while also competing within them with their own apps. This gives app market operators an incentive for self-preferencing: they promote their own apps over third-party apps, consequently distorting competition and harming app innovation. Uncertainty remains regarding how self-preferencing can effectively be counteracted with public policy interventions. Although legislators have advanced bills to restrict self-preferencing, including the Digital Markets Act, existing theoretical models are scant, make mixed predictions, and lack empirical validation. This uncertainty is problematic because app markets represent a complex node of the digital economy where regulatory interference—if not done “right”—can likewise harm innovation. This project will empirically evaluate which public-policy interventions against self-preferencing are effective in restoring app developers’ innovation incentives. It will (i) explain the effects, conditions, and mechanisms through which the interventions function and compare, (ii) permit a validation of existing theory, and (iii) aid stakeholders and government agencies in developing appropriate strategies. To achieve this objective, this project will (i) conduct four in-depth quasi-experimental studies, (ii) which exploit plausibly exogenous policy-changes against self-preferencing, (iii) leverage unique time-series product-level data from mobile app markets, and (iv) integrate the findings into a holistic understanding using measurement and analyses protocols. An extensive communication plan ensures the transfer of scientific expertise into public knowledge.

Keywords: platforms,multi sided markets,network effects,app markets,regulations,innovation