Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Brain Imaging Return to Health (R'BIRTH)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Finland,Ireland,Sweden,Germany,Belgium,United Kingdom,Denmark
Call:  (FP7-PEOPLE-2013-ITN, 2013)
Start date: 2013-09-01
End date: 2017-08-31
Duration (months): 48.0
Total project cost (EUR): 4214310.0
EU funding (EUR): 4214310.0
Participants: 10
Project status: CLOSED

Extended lifespan is a new and permanent feature of human life globally. The demographic for population growth of persons over 60 years is predicted to expand by 70% and 400% respectively in developed and less developed regions during the coming decades. Ageing, is accompanied by cognitive decline and greater risk of depression and anxiety. Major drug companies have recently cutback significantly on development of drugs against brain disorders due to lack of new avenues of research. Thus the responsibility falls on academic labs to make breakthroughs to improve brain health. This consortium gathers experts on molecular mechanisms of age-associated pathologies including depressive disorders and anxiety, and neurodegeneration. Specifically, they focus on identification of stress-regulated molecules provoking neuronal death and hindering neurogenesis, and monitoring the consequences of these processes in human brain. The groups combine biological and medical imaging techniques with behavioral studies and proteomics to define molecular mechanisms of ageing and neurogenesis. Using biotechnology, they will create new tools to isolate neurogenic cells from aged brain, thus aiding research strategies an early stage. Four leading imaging infrastructures from across Europe selected from the ESFRI Eurobioimaging Proof-of Concept list have been selected as partners to facilitate this training and research program. Confocal and high-content imaging is used to define ageing pathways, proteomics and genomics to visualize effectors of pathological ageing, transgenic mice to study neurogenesis and MRI/MRS to identify and localize new depression-related parameters in select patient populations. This multi-faceted approach aims to (i) identify druggable targets and identify reagents to interfere with pathways contributing to depression and anxiety, and (ii) produce novel tools to image depression-associated events in brain, facilitating earlier diagnosis and intervention.

Keywords: depression,anxiety,proteomics,genomics,brain,antibodies,imaging
PReventing, Interdicting and Mitigating Extremist events: Defending against lone actor extremism (PRIME)

Framework: FP7 — Cooperation
Programme: Security
Destination: Security and society
Action type: Collaborative project
Countries involved: United Kingdom,Poland,Denmark,Israel,Netherlands
Call:  (FP7-SEC-2013-1, 2013)
Start date: 2014-05-01
End date: 2017-04-30
Duration (months): 36.0
Total project cost (EUR): 3590953.8
EU funding (EUR): 2842878.45
Participants: 6
Project status: CLOSED

The PRIME project will support the design of technologies (counter-measures and communication measures) for the prevention, interdiction and mitigation of lone actor extremist events (LOEEs), which are hard to anticipate, yet can be highly damaging to local and national communities and therefore must be addressed. Given the difficulty in detecting LOEEs, prevention-based strategies must be complemented by interdiction- and mitigation-based measures, to minimize harm in the event of detection failure. These measures must be accompanied by communication strategies aimed at a range of audiences, including extremists and the general public. The PRIME project will deliver a knowledge-base to inform the design of measures to defend against LOEEs, by achieving the following objectives: 1): Characterising a) the risk posed by lone actor extremists, and b) the context in which measures to defend against LOEEs may be implemented; 2) Producing a cross-level risk analysis framework within which to articulate the key factors and processes implicated in LOEEs, across all stages of the event (radicalisation, attack preparation, attack). 3): Translating the risk analysis framework into a meta-script of lone actor extremist events, and developing methodologies and techniques to produce empirically-supported scripts of each stage. 4): Producing an integrated, cross-level script of LOEEs, and identifying categories of intervention points or 'pinch points'. 5): Delivering a portfolio of requirements for the design of measures for the prevention, interdiction and mitigation of lone actor extremist events across levels of intervention, informed by the analysis of the event script and an understanding of the context in which these measures may be implemented. 6): Delivering a portfolio of requirements for communication measures directed at a diverse audience at each stage of the script, in coordination with the portfolio of counter-measures.

Keywords: extremism terrorism radicalisation prevention mitigation counter-terrorism
Innovative, mechanistic-based strategies for delivery of therapeutic macromolecules across cellular and biological barriers (PATHCHOOSER)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland,Denmark,Germany,United Kingdom,Germany,United Kingdom,United Kingdom,Cyprus
Call:  (FP7-PEOPLE-2013-ITN, 2013)
Start date: 2013-10-01
End date: 2017-09-30
Duration (months): 48.0
Total project cost (EUR): 3036614.02
EU funding (EUR): 3036614.02
Participants: 9
Project status: CLOSED

Nanomedicine offers capability to significantly change the course of treatment for life-threatening diseases. Many of the most significant current therapeutic targets, to be viable in practice, require the efficient crossing of at least one biological barrier. However, the efficient and controlled crossing of the undamaged barrier is difficult. The range of small molecules that can successfully do so (via diffusive or other non-specific processes) is limited in size and physiochemical properties, greatly restricting the therapeutic strategies that may be applied. In practice, after several decades of limited success, there is a broad consensus that new multi-disciplinary, multi-sectoral strategies are required. Key needs include detailed design and understanding of the bionano-interafce, re-assessment of in vitro models used to assess transport across barriers, and building regulatory considerations into the design phase of nanocarriers. The overarching premises of the PathChooser ITN are that (i) significant advances can only be made by a more detailed mechanistic understanding of key fundamental endocytotic, transcytotic, and other cellular processes, especially biological barrier crossing; (ii) elucidating the Mode of Action / mechanism of successful delivery systems (beyond current level) will ensure more rapid regulatory and general acceptance of such medicines. Paramount in this is the design and characterization of the in situ interface between the carrier system and the uptake and signalling machinery. (iii) inter-disciplinary knowledge from a range of scientific disciplines is required to launch a genuine attack on the therapeutic challenge. The PathChooser ITN program of research and training will equip the next generation of translational scientists with the tools to develop therapies for a range of currently intractable (e.g. hidden in the brain) and economically unviable diseases (e.g. orphan diseases affecting a limited population).

Keywords: bionano-interface,biological barriers,therapeutics,regulation,entrepreneurial,training,mobility,inter-sectoral,multi-disciplinary,nanocarriers
Training in neurodegeneration, therapeutics intervention and neurorepair (TINTIN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Ireland,United Kingdom,Spain,Germany,Italy,Türkiye
Call:  (FP7-PEOPLE-2013-ITN, 2013)
Start date: 2013-10-01
End date: 2017-09-30
Duration (months): 48.0
Total project cost (EUR): 3817235.0
EU funding (EUR): 3817235.0
Participants: 8
Project status: CLOSED

Dopamine neurons play a central role in major illnesses, such as anxiety and mood disorders, schizophrenia, autism-spectrum disorders, Parkinson’s disease, epilepsy, and dementia. A multidisciplinary approach must be taken by European researchers to discover the molecular basis of dopamine neurodegeneration and how new technologies will lead to repair and regeneration of neuronal systems in the brain. The TINTIN proposal describes how early stage researchers (ESRs) and experienced researchers (ERs) will undertake advanced research training projects on metabolism and autophagy in neurons, induced pluripotent stem cells and neurorepair systems. Parallel research projects will involve computational modelling of metabolism in the dopamine neuron and the in silico design of novel therapeutics that are selectively transported into the dopamine neuron. This fundamental training and research will be merged with new cutting edge glycan based biomarker technologies, drug simulation and computational/mathematical models of dopaminergic neurons. TINTIN will train young researchers by merging key research groups in 7 Universities and 8 industry/SME partners from Western Europe (Ireland, UK) across central and Southern Europe (Denmark, Germany, Austria, Italy, Spain) and Eastern Europe (Turkey). The secondments of ESRs and ERs into and out of 8 commercial partners in the area of glycan discovery and drug design will ensure that researchers receive intensive training in emerging research areas in neurotherapeutic development as well as key information in how to commercialize such innovation and discovery. The breadth of the aims, techniques and knowledge of TINTIN, the academic basis, the integrating of ESRs and ERs into industry, the potential for transfer to the European pharmaceutical industry, and enrichment of scientific training across Europe all fit the ITN model.

Keywords: brain,dopamine neurons,neurodegeneration,parkinson's disease,autophagy,metabolism,mitochondria,glycomics,biomarkers,computational modelling,target identification,neurorepair
Training & Research Involving Polymer Optical Devices (TRIPOD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Initial Training Networks
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom,Denmark,Poland,Cyprus,Spain,Germany,Denmark,Denmark
Call:  (FP7-PEOPLE-2013-ITN, 2013)
Start date: 2013-10-01
End date: 2017-09-30
Duration (months): 48.0
Total project cost (EUR): 3089229.0
EU funding (EUR): 3089229.0
Participants: 8
Project status: CLOSED

The project is located in the field of optical fibre sensors - an area where Europe has developed internationally competitive research and commercial activity. The aim is to significantly extend the range of application of optical fibre grating sensors by developing a mature version of the technology in polymer optical fibres and thereby increase European competitiveness. Polymer fibres offer some key advantages over silica, the two most important perhaps being the ability to sense much higher strains and the considerably reduced stiffness of the plastic compared to the glass fibre. Polymers are however complex materials and the properties of a sensor in this material are dependent on all stages of the sensor fabrication process, from initial preform production, through fibre drawing to grating fabrication. In TRIPOD we have brought together an interdisciplinary scientific team with expertise covering all aspects of the sensor fabrication path to enable us to obtain a full understanding of the process, with the aim of enabling us to produce optimised grating sensors, efficiently, repeatably and reliably. Integral to the programme are end-user companies who will provide direction on sensor development and training to the researchers on business issues, as well as familiarising themselves with the new technology, enabling them to expand their business models. In addition, we include technology innovators to open up further applications and potential markets.

Keywords: polymer optical fiber,bragg grating,sensor
AdVanced Aerodynamic Tools for lArge Rotors (AVATAR)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable electricity generation
Action type: Collaborative project
Countries involved: Netherlands,Netherlands,Denmark,Germany,Germany,Germany,Spain,United Kingdom,Greece,Italy,Germany,Denmark
Call:  (FP7-ENERGY-2013-1, 2013)
Start date: 2013-11-01
End date: 2017-12-31
Duration (months): 50.0
Total project cost (EUR): 9203394.76
EU funding (EUR): 6680488.65
Participants: 14
Project status: CLOSED

The motivation for the AVATAR project lies in the fact that upscaling wind turbine designs towards 10-20 MW requires radical innovations to make this feasible. Many of these innovationshave a strong aerodynamic component and can be considered as unconventional from an aerodynamic point of view. As such the analysis of the resulting rotor designs falls outside the validated range of applicability of the current state of the art computational aerodynamic tools. The overall objective of the AVATAR project is then to evaluate, validate and improve aerodynamic and aero-elastic tools to ensure applicability for large wind turbines. The capability of these models to produce valid load calculations at all modeling complexity levels needs to be demonstrated. This leads to a number of secondary objectives related to the assessment and evaluation of such designs eventually culminating in new design guidelines. In the AVATAR workplan aerodynamic models are developed and calibrated for all aspects which play a role in the design of large wind turbines. Thereto the entire chain of aerodynamic modelling is mobilized ranging from computational efficient engineering tools to very advanced high fidelity but computationally expensive tools. The development of new comprehensive models is based on a philosophy in which the high fidelity tools feed results towards the lower complexity tools where furthermore (wind tunnel and field) measurements are used to validate and improve the models. The capabilities of the resulting tools are demonstrated on a large scale rotor with and without flow control devices. The project is carried out by an absolute world class consortium since it consists of a selected group of participants from the subprogram aerodynamics of EERA Joint Program Wind (European Energy Research Alliance) in which all leading institutes on the field of aerodynamics participate, complimented with two leading industrial partners.

Keywords: windenergy,aerodynamics,aero-elasticity,tools,flow devices
High Performance Capture - HiPerCap (HIPERCAP)

Framework: FP7 — Cooperation
Programme: Energy
Destination: CO2 capture and storage technologies for zero emission power generation
Action type: Collaborative project
Countries involved: Norway,Netherlands,Spain,Australia,Russian Federation,France,United Kingdom,Austria,Spain,Netherlands,United Kingdom,Canada,Netherlands
Call:  (FP7-ENERGY-2013-1, 2013)
Start date: 2014-01-01
End date: 2017-12-31
Duration (months): 48.0
Total project cost (EUR): 7741512.0
EU funding (EUR): 4890111.0
Participants: 17
Project status: CLOSED

This proposal aims to develop high-potential novel and environmentally benign technologies and processes for post-combustion CO2 capture leading to real breakthroughs. The proposal includes all main separation technologies for post-combustion CO2 capture; absorption, adsorption and membranes. Enzyme based systems, bio-mimicking systems and other novel forms of CO2 binding will be explored. For each technology we will focus on chosen set of promising concepts (four for absorption, two for adsorption and two for membranes). We aim to achieve 25% reduction in efficiency penalty compared to a demonstrated state-of-the-art capture process in the EU project CESAR and deliver proof-of-concepts for each technology. The various technologies and associated process concepts will be assessed using a novel methodology for comparing new and emerging technologies, for which limited data are available and the maturity level varies substantially. Based on the relative performance using various performance indicators, a selection of two breakthrough technologies will be made. Those two technologies will be further studied in order to do a more thorough benchmarking against demonstrated state-of-the-art technologies. A technological roadmap, based on a thorough gap analysis, for industrial demonstration of the two technologies will finally be established. HiPerCap involves 14 partners, from both the public and private sectors (research, academia, and industry), from 6 different EU Member States and Associated States, and two International Cooperation Partner Countries (Russia and Australia). The HiPerCap consortium includes all essential stakeholders in the technology supply chain for CCS: power companies, RTD providers, suppliers, manufacturers (of power plants, industrial systems, equipment, and materials), and engineering companies.

Keywords: post-combustion capture,absorption technology,adsorption technology,membrane technology,process development,large scale application,assessment methodology,co2-binding,enzymes,bio-mimicking
Remediation and mitigation of CO2 leakage (MIRECOL)

Framework: FP7 — Cooperation
Programme: Energy
Destination: CO2 capture and storage technologies for zero emission power generation
Action type: Collaborative project
Countries involved: Netherlands,France,Germany,United Kingdom,United Kingdom,Netherlands,Norway,Serbia
Call:  (FP7-ENERGY-2013-1, 2013)
Start date: 2014-03-01
End date: 2017-02-28
Duration (months): 36.0
Total project cost (EUR): 5250775.2
EU funding (EUR): 3756249.0
Participants: 11
Project status: CLOSED

Safety, reliability and controllability are essential elements influencing the public perception and licensing of CO2 storage. Therefore a thorough analysis of leakage mechanisms and threats to the safety and security of storage will be the first activity in the MiReCOL project. This will form the basis for an analysis of mitigation and remediation options. Both existing (state-of-the-art) and new remediation and mitigation techniques will be investigated, including laboratory tests of sealant materials and field demonstrations at the sites of Ketzin (Germany) and Bečej (Serbia). Additional field experiments that cannot be afforded by MiReCOL only will be shared with top-ranked US and Australian partners. The approach in MiReCOL is strictly risk based, which ensures that the results of the project can feed into the regulatory process (protocols, safety regulations, guidelines). This means that the impact of each remediation and mitigation measure is assessed on all relevant risk levels. The results will be published both as handbook and as an interactive web-based tool, to inform both storage project operators and competent authorities on the options available for remediation and mitigation. The inclusion of industrial partners active in CO2 storage ensures the operational experience to assess the efficiency and impact of each measure.

Keywords: co2 storage,remediation,mitigation,corrective measures
District of the Future (DOF)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: ICT for a low carbon economy
Action type: Collaborative project
Countries involved: Spain,Spain,France,Finland,France,France,United Kingdom
Call:  (FP7-SMARTCITIES-2013, 2013)
Start date: 2013-11-01
End date: 2016-10-31
Duration (months): 36.0
Total project cost (EUR): 6148899.0
EU funding (EUR): 3801732.0
Participants: 14
Project status: CLOSED

Cities are increasingly recognizing the need of addressing climate and energy challenges. The District of the Future (DoF) project is a project funded by the European Union (EU) with the objective to increase energy efficiency in a city district using innovative Information and Communication Technology (ICT) approaches. It will help city leaders to achieve quantifiable and significant reduction up to 30 to 40% of energy consumption and CO2 emissions and will improve citizen awareness and people involvement. The project will be executed by a consortium formed by a world leader in integrated telecommunications, technological consultancy firms, ICT software and equipment providers, SMEs, a Research and Development organization, energy companies and the public authorities of the cities of Sabadell (Spain), Orléans (France) and Corby (UK) that will provide the real life environment for the project. DoF will use ICT to collect, register and monitor energy data and bring this to a cloud-based software platform. This platform will analyze energy patterns in each city district. That will allow predicting energy consumption and energy production behavior in each district. DoF will provide a system based upon standardized state-of-the-art communications, that will support city authorities and citizens in taking the right decisions in order to optimize energy systems and improve energy efficiency in the involved city districts. The project will contribute to the adoption of green ICT technologies by city authorities. Just by reapplying the DoF approach in other European city districts the project will make a sustainable contribution to the objectives of EC 2020 Energy and Climate Change, 20% of energy from renewable, 20% increase of energy efficiency, 20% reduction of greenhouse gas emissions in comparison with 1990.

Keywords: smart grid,chp,smart cities