Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Impact Licensing Initiative (ILI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Coordination and support actions
Countries involved: Belgium,Germany,Croatia,United Kingdom
Call: Toolbox for efficient IP licensing for market uptake and societal value creation (CSA) (HORIZON-CL4-2023-HUMAN-01, 2023)
Start date: 2024-08-01
End date: 2027-07-31
Duration (months): 36.0
Total project cost (EUR): 2143000.0
EU funding (EUR): 1778125.0
Participants: 5
Project status: SIGNED

Technologies and data are still underused or sub-optimally allocated to solve the societal challenges of today in Europe and beyond. Moreover, the COVID pandemic and the recent war in Ukraine has revealed that (health, environment, energy,…) chocks in our systems create new technology needs and gaps in our access to necessary technologies in Europe itself. Impact licensing is a strategic instrument to optimize the valorization potential of technologies and data without losing sight of the economic dimension. It is a time-bounded voluntary permission granted by a technology holder to bring at preferred conditions an IP, a technology, a product or a service to a pre-defined market for a specified societal purpose which can be a societal or environmental unmet need or triggered by a crisis. Moreover, the impact licensing mechanism creates for technology holders important incentives for market exploration, reverse (frugal) innovation and access to real world data on technology performance and outcome /impact indicators. This project aims to develop an integrated toolkit (6 instruments and 2 training modules) and a network of intermediaries (=clearing houses) across the EU to introduce impact licensing as an IP instrument (a) for societal value creation with focus on the UN SDG goals, (b) as an instrument for a resilient Europe that guarantees access to technology and data during crisis , (c) as a driver for innovation and research through performance data access and insight for technology improvement and (d) as a smart tool for (emerging) market exploration.

Keywords: impact licensing,societal value creation,take up of new technology transfer practices,collaboration licenses contracts and pooling agreements,technology access during regional crisis
Synthesis of Bio-based and Biodegradable polymers from monomers from renewable Biowastes via Biocatalysis and Green Chemistry to contribute to European Circular Bioeconomy (Polymers-5B)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Research and Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Portugal,Latvia,Spain,Netherlands,Germany,Serbia,Italy
Call: Development of novel, high-performance bio-based polymers and co-polymers (HORIZON-JU-CBE-2023, 2023)
Start date: 2024-06-01
End date: 2028-05-31
Duration (months): 48.0
Total project cost (EUR): 5264779.0
EU funding (EUR): 5264779.0
Participants: 13
Project status: SIGNED

POLYMERS-5B aims to develop novel alternative biobased polymers synthesized from biobased monomers (diacids, diols, diamines, hydroxyacids, aminoacids, aromatic and phenolic compounds, fatty acids, oils, furans), sourced from underexploited second generation (2G) feedstocks such as agri/food waste (Tomato and Olive wastes) and biomass (wood pulp and lignin derivatives), obeying the food first and cascading principle. The project will resort to Biocatalysis and Green Chemistry processes to generate novel biobased polymers like polyesters and polyamides with pendent functional groups, (e.g., hydroxy, carboxylic, amine, epoxy, thiol, others), polyphenols and poly-furans, that mimic fossil-based polymers properties (e.g., polyethene terephthalate-PET, Polyurethanes-PUs, Acrylonitrile butadiene styrene-ABS, Amine and other polymeric resins), targeting improved biodegradability. These new polymers will be blended to provide valuable bio-composites and polymeric materials for the textile, automotive, furniture and polymeric resin markets. Machine Learning (ML) tools will drive the optimization of the developed technologies towards minimum resource usage “zero waste” and “zero pollution”, while technological, economic, and environmental sustainability aspects will be incorporated early in the design phase by adopting Sustainable by Design (SSbD) approaches. This sustainable strategy will contribute to an increase in the availability of monomers, bio-based polymers & plastic materials synthesized in the EU, that meet the Green Deal targets, reducing the carbon footprint and dependency on fossil-based raw materials and derivatives.

Keywords: biocatalysis,green chemistry processes,sustainable by design,machine learning
Functional characterization of the colorectal cancer metastasis microbiome (METABAC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 1499894.0
EU funding (EUR): 1499894.0
Participants: 1
Project status: SIGNED

Host cells and microbial inhabitants form an intricate ecosystem in the human body, extensively influencing host phenotypes in health and disease. Despite much progress in sequencing-based cancer microbiome research, elucidating functional roles of bacteria in metastasis formation remains an important unsolved challenge. In the METABAC project, we will explore such bacterial roles as drivers of colorectal cancer metastasis. We will investigate new concepts on whether bacteria can equip cancer cells with malignant features, migrate within the host and potentially represent targets for cancer therapy. In Aim 1, my group will characterize the microbial inhabitants of colon tumors and metastases. We will uncover bacterial species and their genetic features in metastases by using sequencing-, imaging- and culturing-based approaches. In Aim 2, we will mechanistically dissect functional impacts of metastasis-derived bacteria on distinct stages of the metastatic process. For this, we will use specialized organoid, organ chip and orthotopic organoid-bacteria co-engraftment platforms that we have pioneered. In Aim 3, uncovering the tropism, timing and routes of bacterial migration to different metastasis sites takes center stage. Bacterial strains and organoids derived from different metastasis sites will be co-engrafted into mice and traced to lymph node, liver and lung metastases. The METABAC project will provide an unprecedented characterization of microbial roles in metastasis. Our combination of metastasis-derived bacterial strains with novel organoid, organ chip and in vivo platforms puts us in a unique position to close the gap between cancer microbiome sequencing and mechanistic studies and promises groundbreaking functional insights into host-microbe interactions in cancer and beyond.

Keywords: cancer microbiome metastasis organoids organ on a chip functional assays bacterial culturing colorectal liver lung
From near extinction to market distinction: Developing a methodology for the sustainable revival of heritage grapevine cultivars (Negev Wine Revival)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-06-01
End date: 2023-11-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Wine grapes (Vitis vinifera) are among the most sensitive crop to global warming. Elevated temperatures lessen the quality of the grapes and alter their distinctive traits. The threat is pushing winegrowers in Europe to look for new cultivars with greater resilience to climate change. Arid regions with longstanding winegrowing traditions are ideal for locating endemic grapevines that are resilient to high temperatures. With its storied history of sustainable dryland viticulture, the Negev desert in southern Israel is a prime location to hunt for novel heritage cultivars that over the centuries were bred for their ability to adapt to prevailing arid conditions. In our preceding ERC project, we examined agricultural and settlement intensification and collapse in the Negev during late Antiquity. We discovered via DNA testing that grape seeds excavated at an 8th C. CE Byzantine archaeological site in the Negev matched with heritage grape cultivars that still grow feral in the region. The current PoC aims to further these findings by formulating a multidisciplinary model for reviving bygone heritage cultivars. Concentrating on the Negev but intending for the broader application of our methodology, we will (1) plan for the efficient commercialisation of our genomic-based approach for matching bygone-but-hardy endemic cultivars with their nearest living relatives, (2) provide proof-of-concept by growing the revived grape cultivars in a Negev vineyard, (3) produce novel ‘Negev Wine’ from feral grape cultivars that will be the first heritage-based commercial wine in Israel that is also in accordance with the Protected Designation of Origin (PDO) platform of the EU, (4) compile ample documentation of the dynamic and initiate an IPR protection process while, (5) involving external stakeholders in the applied integration within the wine sector of our ‘from near extinction to market distinction’ methodology.
MiRACLE:Millimeter scale Repeatable and Absolute Coherent Localization Enablers (MiRACLE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-01
End date: 2028-01-31
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 2
Project status: SIGNED

In recent years, wireless localization and sensing have gained significant traction in the industry, and the requirements in terms of accuracy and reliability have become tighter and tighter. Project Millimeter scale Repeatable and Absolute Coherent Localization Enablers (MiRACLE) aims to blur the line between wireless localization and metrology by pushing the accuracy of absolute wireless localization systems below the millimeter accuracy while maintaining repeatable performance over environmental changes. This will enhance the efficiency of future manufacturing plants, as well as enable life-saving technologies like telesurgery. To achieve these ambitious goals, it will exploit coherent information from a combination of all the cellular frequency bands, including the upcoming FR3 band (7GHz-24GHz) present in the 6G roadmap. Due to the recent introduction of FR3, there is a lack of commercial experimental hardware operating in that band. For this reason, the project also aims to provide an open-source experimental setup capable of operating at those frequencies.

Keywords: localization,positioning
EastGate Hydrogen Valley (EASTGATEH2V)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Slovakia,Ukraine,Slovenia,Germany,United Kingdom,Netherlands,Spain
Call: Small-scale Hydrogen Valley (HORIZON-JTI-CLEANH2-2024, 2024)
Start date: 2025-04-01
End date: 2031-03-31
Duration (months): 72.0
Total project cost (EUR): 12303989.9
EU funding (EUR): 8999997.98
Participants: 22
Project status: SIGNED

EASTGATEH2V will deploy an integrated H2 ecosystem in the region of Kosice, Slovakia. It brings together all core elements of the value chain i.e. production, distribution infrastructure and end-use of renewable hydrogen across mobility and industry. The project is based on the integration of 4 deployment sites across the region, including 4MW of newly deployed electrolyser capacity deployed in two stages (2 MW alkaline and 2 MW PEM respectively), connected by H2 trailer distribution to 4 distinctive mobility end-user applications, namely buses and a garbage truck, a H2-powered touristic boat and aviation VTOL vehicles, along with delivery of H2 to existing industrial applications. The objective is to facilitate full integration and operational interconnectivity of all these H2 applications with the existing regional transport, industry and broader energy system. EASTGATEH2V will also deliver studies for scaling-up the regional ecosystem, including deployment of pipeline H2 infrastructure at transmission and distribution level, along with studies for the deployment of large-scale renewable H2 supply in neighbouring Ukraine including pipeline interconnections with Kosice region. The EU replicability of this regional H2 ecosystem will be showcased via replication studies with other CEE regions. EASTGATEH2V also aims to address public perception towards hydrogen, by ensuring high visibility of the H2 Valley project to local communities, through a comprehensive communication and dissemination plan. The aim is to expand the project reach beyond technology demonstrations, analysing also its socio-economic impacts, and providing CEE regions with a blueprint for decarbonization of their economies, and an example of the contribution of H2 Valleys towards the EU energy, industry and net zero targets. EASTGATE H2V is an integrated collaborative project, aiming to ensure the uptake of hydrogen and the deployment of H2 Valleys in other regions across EU and beyond.

Keywords: eastern europe,gateway,pipeline,h2 regional ecosystem
Accelerating the development of mating disruptors for disease-transmitting mosquito control (STOP-MATING)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Central African Republic,Madagascar,Italy,Germany,United Kingdom
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2025-03-01
End date: 2029-02-28
Duration (months): 48.0
Total project cost (EUR): 261542.86
EU funding (EUR): 257600.0
Participants: 8
Project status: SIGNED

STOP-MATING aims at building a research and innovation network to advance towards developing novel tools to target the mating behaviour of disease-transmitting mosquitoes for vector control. Challenges related to climate change and insecticide resistance are putting human populations at risk of mosquito-borne diseases. Novel strategies are required to tackle this public health challenge. In STOP-MATING we propose to use the mating systems of disease-transmitting mosquitoes as novel vector control targets. Although disrupting mosquito mating would have a clear impact on mosquito vector numbers, this mechanism is underexploited from a public health perspective. In STOP-MATING we bring together experts from academic and industrial partners with interdisciplinary expertise on bioinformatics, molecular neuroscience, genetic control, behaviour, biophysics, vector ecology and vector control to explore novel vector control approaches. Our objectives are to 1) identify molecular targets for mosquito mating disruption, 2) mutate those targets, 3) analyse associated behavioural effects and 4) explore their potential application into developing mating disruptors and gene drive systems for vector control. We also aim at exploiting the mating behaviour of mosquitoes to develop traps that mimic the environmental stimuli that they respond to during courtship behaviour. STOP-MATING approach is to merge knowledge from laboratory and field researchers to deliver real-world solutions, and to tackle different mosquito species of increasing public health relevance in Europe. Our innovative approaches have the potential to make great impact to reduce the health burden of mosquito-borne diseases.

Keywords: mosquito,vector borne diseases,zoonoses,malaria,arbovirus,mating disruptor,hearing,swarming,insecticide,drug discovery,innovative control,gene drive,phonotaxis
Methodologies for Teamworking in Eco-Outwards Research (METEOR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Coordination and support actions
Countries involved: Poland,Norway,United Kingdom,Italy,Cyprus,Finland,Türkiye,Georgia,Spain,Denmark,Austria,Brazil
Call: Methodologies for teamworking of researchers – reinforcing transversal collaborative skills, behavioural and implementation sciences (HORIZON-CL2-2024-TRANSFORMATIONS-01, 2024)
Start date: 2024-12-01
End date: 2027-11-30
Duration (months): 36.0
Total project cost (EUR): 3108736.88
EU funding (EUR): 2989299.38
Participants: 13
Project status: SIGNED

The overall aim of METEOR is to improve the transversal skills of current postgraduates and early career researchers, with consequent benefits to research ecosystems, in line with Open Science and Responsible Research and Innovation (RRI) and focused on the UN Sustainable Development Goals. METEOR emphasizes the capacity to collaborate, work in groups and to develop international transdisciplinary projects oriented towards societal challenges and doctoral employment opportunities. METEOR has 6 specific objectives (SO) corresponding to its work package structure: SO1: Effective Management (WP1). SO2: Collect, analyse and report evidence supporting the need for an innovative doctoral training program (WP2). SO3: Develop a comprehensive transversal skills training program comprising a suite of 10 online training resources, using participatory methodologies co-created with the PhDs, ECRs, institutions and researchers, to enhance the skills specified in the Call (WP3). SO4: Implement the resources from WP3 and related activities in online and in-person delivery mode, with online and F2F events, and Peer Mentoring Groups consisting of 4-6 researchers collaborating for 15 months, with a target of 300 +/- individuals in 50 groups, preparing 50+ proposals based on UN SDGs and focused on impact (WP4). SO5: Create policy and exploitation routes for increasing the scope of doctoral training at local and national levels (WP5). SO6: Communicate and disseminate METEOR activities and results to a wider audience and ensure project’s continuity beyond the funded period (WP6). METEOR activities will benefit doctoral candidates (employment prospects/ earnings), institutions (recruiting PhD candidates, better supervision, more impactful research), industry/public sector (employees with high level research and transversal skills) and society generally (more research focused on challenges).

Keywords: doctoral education,transversal skills,transdisciplinarity,sustainable development,peer mentoring,collaborative research
The impact of germline metabolic reprogramming on reproduction and physiology (SweetEggs)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Portugal
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1481513.0
EU funding (EUR): 1481513.0
Participants: 2
Project status: SIGNED

Animals are composed of multiple tissues with different metabolic needs. During differentiation, the establishment of specific metabolic programs allows cells to acquire specialized functions. The nutrients that fuel these cell-specific metabolic pathways are obtained via the diet. In order to secure proper nutrient supply to these tissues, the central nervous system accesses their metabolic states, allowing the animal to mount behavioral strategies to adapt nutrient appetite. Our understanding of how cell-specific metabolic programs regulate animal physiology and behavior has been hindered by the lack of tractable experimental systems. Using Drosophila melanogaster I uncovered that the germline undergoes metabolic reprogramming, upregulating a specific carbohydrate metabolism branch, the pentose phosphate pathway (PPP) and that oogenesis progression requires the supply of dietary sugars, fueling this pathway. I further showed that the germline communicates its metabolic status to the fat body (FB), regulating the transcription of a satiety factor that acts on the brain to regulate sugar appetite. These findings represent a unique experimental platform, which I will use to study how cell-specific metabolic programs and nutrition regulate whole-animal animal physiology and fertility. I will: 1) identify the transcriptional factors regulating metabolic reprogramming in the germline; 2) test the requirement of specific PPP metabolites in germline cell functions and fertility; and 3) identify the molecules mediating the ovary-FB signaling axis and characterize their impact on FB transcriptional regulation, nutrient appetite, and fertility. Metabolic dysfunctions are known to result in many human conditions. This proposal will not only contribute to our understanding of how metabolism ensures reproduction, but will also help developing dietary interventions to tackle impactful human disorders including infertility.

Keywords: metabolic programs,germline,fertility,inter organ communication,diet,drosophila,oogenesis,nutrient appetite,pentose phosphate pathway