Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Beauty and Inequality: Physical Appearance, Symbolic Boundaries and Social Dis/advantage in Five Global Cities (BINQ)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Belgium
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-01-01
End date: 2028-12-31
Duration (months): 72.0
Total project cost (EUR): 2499333.0
EU funding (EUR): 2499333.0
Participants: 1
Project status: SIGNED

How does physical beauty contribute to social inequality? This innovative multi-disciplinary comparative project aims to build a comprehensive new theory that explains how evaluations of physical appearance work, and how they re/produce durable inequalities in today’s media-saturated, service-based consumer societies. It hypothesizes that 1. in contemporary societies beauty is an important form of capital for all genders over the life-course; 2. beauty as a form of capital intersects with existing axes of inequality like gender, race, class, age, sexuality, nationality; 3. the growing importance of appearance spawns new forms of inequality. The project investigates these hypotheses in 5 global cities on 4 continents: Accra, Brussels, Buenos Aires, Hong Kong and Tehran. An international team will employ a mixed-method design to study how aesthetic evaluations of appearance are shaped, and identify the mechanisms by which these evaluations shape social dis/advantage. This high risk/high gain project breaks new ground in our understanding of human beauty and its consequences. It brings together scattered insights from many disciplines in a new theoretical model, and tests and refines this model with explorative (Q-sort, survey, ethnography) and hypothesis-testing (lab/ field experiments) methods. It addresses central societal and scientific challenges by foregrounding the importance of a “soft” cultural factor in shaping social divides, and the growing role of media in shaping social dis/advantage and exclusion. All subprojects study two domains where mediatization has made appearance more salient: dating and job search. The project structure is designed to tackle its high risks: its global scope, multidisciplinarity and its ambition to simultaneously develop novel methods and a new theory. The project is led by a cultural sociologist with a strong track record in interdisciplinary and comparative research, and in analyzing the serious consequences of frivolous topics.

Keywords: beauty inequality media appearance repertoires evaluation exclusion globalization mixed methods comparative boundaries disadvantage cultural sociology dating job search stratification
GREENS: A Training Programme on 5R's implementation in the design, manufacturing and application of micro and nanorobotic platforms (GREENS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Italy,Hungary,Austria,Germany,Switzerland,Sweden,Denmark,Netherlands,Portugal,Greece,United Kingdom
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-02-01
End date: 2029-01-31
Duration (months): 48.0
Total project cost (EUR): 3988756.8
EU funding (EUR): 3754893.6
Participants: 23
Project status: SIGNED

Micro- and nanoscale robotic platforms have captured the attention of researchers due to their remarkable ability to perform tailored tasks with unparalleled precision and minimal invasiveness. These robots hold great promise, with the potential to revolutionize fields ranging from biomedicine to environmental applications. From catalytic to externally actuated robots (i.e., magnetic, light), these robots offer the possibility of targeted drug delivery and enhanced reactivity due to their autonomous motion. Moreover, the recent interest in the collective behavior of micro- and nanorobots as swarms has gone hand-in-hand with the implementation of degradable materials to ensure its later removal from the body. Currently, the main focus in the field relies on the design, fabrication, and implementation of such robots, with special emphasis on achieving proper delivery, manipulation and final automation of large quantities of them. In addition, it is also important to explore cost-efficient and mass-production fabrication techniques to ensure that micro- and nanorobots can be manufactured and deployed at scale. However, one aspect that has not received enough attention is the waste management cycle associated with the fabrication and use of these robots. In the GREENS project, we aim to implement for the first time the 5R (Reduce, Recycle, Rethink, Repair, and Reuse) principle from the manufacturing to the final implementation and removal of nano/micro robotic platforms, always accounting for the sustainability of the overall process to minimize the impact of fabricating/applying them to the environment. This initiative is aligned with the sustainable development goals established by the European Comission (EC), and is of great importance to the Environmental Action Program from the EC.

Keywords: microrobots,degradable materials,sustainability,life cycle analysis,5rs
CAMS AERosol Advancement (CAMAERA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: France,Netherlands,Germany,Norway,Finland,Spain,United Kingdom,Poland,Denmark,Sweden,Italy
Call: Copernicus for Atmosphere and Climate Change, including CO2 (HORIZON-CL4-2023-SPACE-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 3268515.28
EU funding (EUR): 2998417.77
Participants: 15
Project status: SIGNED

The European Union’s flagship Space programme Copernicus provides a key service to the European society, turning investments in space-infrastructure into high-quality information products. The Copernicus Atmosphere Monitoring Service (CAMS, https://atmosphere.copernicus.eu) exploits the information content of Earth-Observation data to monitor the composition of the atmosphere. By combining satellite observations with numerical modelling by means of data assimilation and inversion techniques, CAMS provides in near-real time a wealth of information to answer questions related to air quality, climate change and air pollution and its mitigation, energy, agriculture, etc. CAMS provides both global atmospheric composition products, using the Integrated Forecasting System (IFS) of ECMWF - hereafter denoted the global production system - , and regional European products, provided by an ensemble of eleven regional models - the regional production system. The CAMS AERosol Advancement (CAMAERA) project will provide strong improvements of the aerosol modelling capabilities of the regional and global systems, on the assimilation of new sources of data, and on a better representation of secondary aerosols and their precursor gases. In this way CAMAERA will enhance the quality of key products of the CAMS service and therefore help CAMS to better respond to user needs such as air pollutant monitoring, along with the fulfilment of sustainable development goals. To achieve this purpose CAMAERA will develop new prototype service elements of CAMS, beyond the current state-of-art. It will do so in very close collaboration with the CAMS service providers, as well as other tier-3 projects. In particular CAMAERA will complement research topics addressed in CAMEO, which focuses on the preparation for novel satellite data, improvements of the data assimilation and inversion capabilities of the CAMS production system, and the provision of uncertainty information of CAMS products.

Keywords: copernicus,aerosols,modelling,data assimilation
Synthetic Chimeric Antigen Receptors: Hijacking Nitrenium Ions for Targeting, Therapy and Safety of Next Generation T Cell Therapy (SynCAR-Ts)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2501154.0
EU funding (EUR): 2501154.0
Participants: 1
Project status: SIGNED

Chimeric antigen receptor (CAR) T cell therapy is a promising approach for cancer treatment with remarkable clinical outcomes. CAR T therapy involves the isolation of patients T cells that are genetically modified with an engineered antigen receptor to attack cancer cells. Despite the great promise, the rapid activation and proliferation of CAR T cells can lead to serious side effects. In addition, CAR T therapy is challenged by limited effectiveness, difficulties in infiltrating solid tumors, targeting of healthy cells, cell exhaustion and an expensive, lengthy and personalized manufacturing process. Over the past years, researchers have explored many strategies to improve and control CAR T cell function and to develop more universal CAR T cell platforms. Yet, an off-the-shelf approach that allows full control of CAR T effector function, that is flexible in use and can be obtained at low manufacturing costs, is currently not available. To address above challenges, I will develop a highly innovative, universal synthetic CAR (SynCAR) T cell platform where the antigen receptor is easily adaptable by using synthetic, functionalized targeting ligands to control T cell effector function in space and time. At the basis of this proposal lies the use of highly reactive and activatable aryl nitrenium ions for protein modification, drug delivery and as novel class of therapeutics. I will 1) tune nitrenium ion reactivity for bioconjugation and drug activation 2) use enzyme-activatable nitrenium ion precursors for synthetically modified antigen receptors, 3) develop novel nitrenium ion-based prodrug strategies to improve CAR T efficiency and 4) use innovative bioorthogonal chemistry to control CAR T activity in time and space. In this work, I will develop beyond the state-of-the-art chemical biology methods and molecular targeting tools to control, potentiate, and tune T cell activity with the ultimate goal to broaden the CAR T targeting landscape to solid tumors and beyond.

Keywords: chemical immunology,bioorthogonal chemistry,self labeling proteins,activity based probes,precision medicine,prodrugs,mechanism based inhibitor,nitrenium ion therapeutics,arylamine n acetyl transferase,chimeric antigen receptor t cells,living medicine
Practical strengthening of regulatory and ethics oversight on clinical trials in West Africa using Lassa Fever vaccine development projects and increase regulatory maturity level in targeted countries (ECOWAS-RegECs)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Coordination and support actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Norway,Ghana,Burkina Faso,Germany
Call: Strengthening regulatory capacity for supporting conduct of clinical trials (HORIZON-JU-GH-EDCTP3-2022-01, 2022)
Start date: 2023-06-01
End date: 2025-07-31
Duration (months): 26.0
Total project cost (EUR): 514961.25
EU funding (EUR): 514961.25
Participants: 4
Project status: SIGNED

The proposed strengthening project for clinical research oversight in ECOWAS region, consists of practical training of regulatory and ethics experts by exposing them to Lassa Fever vaccine development from early to late clinical stage. The exposure to novel technologies in vaccine development and the opportunities to responsibly oversee the full clinical development pathway of vaccines for Africa can inspire and attract regulators and ethics experts/talents, and by this contribute to maintaining, enhancing and further developing the workforce at the agencies and ethics institutions. The project intends to enhance the Maturity Level for Regulatory Systems and clinical trial oversight function of 2-4 authorities in the ECOWAS region. Ghana FDA will lead the intended work, with CEPI as project coordinator, Paul-Ehrlich-Institut as supporting agency and WAHO ensuring the dissemination and engagement among ECOWAS countries. The consortium between GFDA, WAHO, PEI and CEPI is confident to assure high quality regulatory and ethics oversight during Lassa Fever vaccine development and to create preparedness of ECOWAS NRAs not only for Lassa vaccine future licensure but also for decisions related to emergency use in case of a major Lassa Fever outbreak. Using the AVAREF platform for scientific advice and CTA simulations and including ECOWAS observer countries in real live clinical trial application assessments will strengthen the common advice and review processes and lead to reliably generate fast decisions by NRAs and ECs in a seamlessly coordinated way. When processes from application to decision are reliable and fast, developers will prefer using AVAREF platform even for single country clinical trial applications. This will open further possibilities for coordinated involvement of observer countries for training purposes. Seamlessly coordinated collaboration on the basis of harmonized and well-defined processes between NRAs, NECs and AVAREF will promote clinical research in Africa and help the AMA operationalization.

Keywords: clinical trial oversight,regulatory strengthening,ethics committees,lassa fever,vaccine for neglected disease,
Breaking new frontiers in the use of NanoSIMS as an analytical tool for inferring the isotopic and critical metal geochemistry of clay-rich geological materials (TRANSITION)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-01-01
End date: 2027-12-31
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

In line with the European Union strategies, the TRANSITION project aims to advance the scientific knowledge of past climates and evaluate critical metal resources. The first objective of the project is to reconstruct palaeoclimatic conditions by analysing the oxygen and hydrogen isotopic composition of clay minerals and oxides in Lower Cretaceous aluminium-rich rocks (laterites and bauxites) from NE Spain. Current limitations in isotopic analysis due to the nanometric scale of these minerals will be overcoming by developing an advanced analytical procedure using NanoSIMS (nanoscale secondary ion mass spectrometry), thus enhancing Europe's capabilities in this area. TRANSITION also aligns with the European Commission's 2023 recognition of certain metals as critical for the energy transition, since laterites, bauxites, and red muds (bauxite by-products after industrial processing) are valuable sources of such metals. The second objective of the project is the NanoSIMS high-resolution grain-scale mapping of the minerals containing critical metals in laterites, bauxites and red muds , thereby determining the sub-micron distribution and specific location of these metals within these materials. The successful implementation of the project, based on the expertise in geological and analytical chemistry of the applicant and supervisor, respectively, will contribute to the research prowess of Europe. The project’s outcome will be of global significance, inspiring geoscientists worldwide to use NanoSIMS and expand our understanding of past climatic conditions. TRANSITION will also contribute to complementing the Lower Cretaceous paleoclimatic record in Western Europe and will report fundamental data for the future design of critical metals extraction strategies, allowing to consider laterites and bauxites as a source of critical metals, as well as the recycling of red muds as repositories of these metals.

Keywords: bauxite critical metals hematite hydrogen isotopes icp ms kaolinite laterite lower cretaceous nanosims nanosims mapping oxygen isotopes red muds smectite chemical weathering
Functionalized graphenes for ink technologies (GRADINK)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Czechia
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-10-01
End date: 2025-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

GRADERINK addresses the pressing need for development of novel inks that can be utilized for inkjet printing of stable, selective, sensitive, and eco-friendly electrodes. Project aims to deliver the upscaling of an industrially relevant novel manufacturing process for graphene-derivative based ink, enabling a significant progress in the printing technologies for versatile electrochemical biosensing platform. Such platform can be utilized for a wide range of medicinally, environmentally and food/water-safety related analytes, such as microbes, antibiotics, pesticides, disease markers, just to name a few. The maintenance of a healthy society necessitates not only monitoring human body status but also screening food, drinking water, air, and environment. Such monitoring requires immediate, on-site, and easy-to-read sensing technologies. Electrochemical biosensors represent an ideal sensing platform because they transduce a specific biochemical event to an electrical signal, which can be readily recorded and processed. The key component of electrochemical biosensors is the electrode, which is used as a solid support for the immobilization of biomolecules and electron movement. Graphene-based materials are ideally suitable for the construction of electrochemical biosensor electrodes because they offer high surface area, unique electrochemical properties, and high biocompatibility. However, graphene itself enables only limited applications and the patterning of graphene-based electrodes remains unsolved challenge. Digital printing technologies represent a novel strategy for patterning of electrodes. Their use, however, requires stable, robust and sustainable inks which are not yet commercially available. GRADERINK’s goal will be achieved through the implementation of cost-effective materials and processes along with taking TRL of the developed technology from 2 to 4, thus shaping a significant business opportunity.
Direct co-processing of CO2 and water to sustainable multicarbon energy products in novel photocatalytic reactor ​ (DESIRED)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Italy,Austria,Czechia,Cyprus,Spain,Poland
Call: Next generation of renewable energy technologies (HORIZON-CL5-2021-D3-03, 2021)
Start date: 2022-11-01
End date: 2026-10-31
Duration (months): 48.0
Total project cost (EUR): 3058752.5
EU funding (EUR): 3058752.5
Participants: 7
Project status: SIGNED

Solar fuels, produced via solar driven CO2 and water conversion can contribute to drastically reducing GHG emissions and implement a man-made carbon-cycle complementing the natural-one, deploying the circular economy strategy. However, at present, significant improvement in the photocatalysts and reactor technology is required for solar fuels’ production to become technically feasible, scalable, affordable, secure, sustainable, and efficient. DESIRED is a high-risk high-return project, focused on establishing the technological feasibility and sustainability of a novel fuel production system – the DESIRED system – for direct coprocessing of, possibly atmospheric, CO2 and water to produce multi-carbon (C2+) energy-rich products using sunlight as primary energy source. The DESIRED system will produce C2+ solar fuels (without overlooking C1 species such as methanol or methane) by direct coprocessing of CO2 and water using novel and recyclable hybrid photo-electrocatalysts, supported on frustules or zeolites, in an innovative photoreactor design applying, for the first time, oscillatory flow principles, combined with direct light irradiation. With regards to applications, DESIRED will focus on products, which, by 2050, would be used per se or as intermediates to produce drop-in fuels for sectors where direct shift to batteries or H2 is not a technically and cost-efficient option (e.g. aviation). Knowledge of the economic affordability, environmental benefits, and social acceptability of this approach will be investigated. DESIRED promotes an interdisciplinary approach to research and innovation undertaken by a consortium of 7 European partners and complemented by cross-cutting activities including modelling, process simulation, sustainability, and techno-economic assessment as well as impactful dissemination, communication, capacity-building and exploitation activities that support the exchange of knowledge across and beyond the consortium and project.

Keywords: catalysis,co2 conversion,direct light irradiation,frustules,hybrid photoelectron catalysts,multicarbon products,photoreactor,solar fuels,solar collector,zeolites