Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Pomeranian Researchers Night: European Challenges and Missions closer to the citizens (NightMission)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Poland
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 276486.72
EU funding (EUR): 276486.72
Participants: 10
Project status: SIGNED

Pomerania Region in northern Poland is home to 2,2 million citizens, with its center of socio-economic gravity concentrated among the seaside metropolitan area (Tri-City). It is in this area, where one of the largest and most important academic and research hubs in Poland is located, consisting of many higher education and research institutions, including those from top 20 of Polish universities. It is also a workplace for more than 7000 researchers, conducting scientific explorations in almost every field of science. Pomorska Noc Naukowców (en. Pomeranian Researchers' Night - PRN) first organized on 29th September 2023, is success of the grassroots initiative of the Pomeranian scientific community. This annual event organized on last Friday of September is first of such scale within the region, and only third one in whole country. Main goal of PRN is to establish a greater impact on the social development of the region by popularizing science, bringing scientists closer to the public, showing how their work affects our everyday life, finally: encouraging children and youth to choose a scientific career in the future. Within the project “NightMission" we shall develop PRN in years 2024 and 2025 by bounding it with Researchers at Schools initiative. The common denominator of activities addressed to the public will be “European challenges”, presented through the prism of the everyday work of scientists in the region. The main goal of NightMission is to achieve enhanced engagement of Pomerania region citizens with European scale excellent research and research teams, within highly inclusive space of Researchers Night and during Researchers at Schools Initiative. Project will be implemented via meetings, classes, workshops and information campaigns, and shall consolidate two main messages: "science is shaping our everyday lives all the time" and "research is the answer to the challenges of the modern world".

Keywords: european challanges,excellent research,science promotion,regional promotion,science popularization
Learning in single cells through dynamical internal representations (CeLEARN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Spain
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-04-01
End date: 2031-03-31
Duration (months): 72.0
Total project cost (EUR): 11133873.0
EU funding (EUR): 11133873.0
Participants: 5
Project status: SIGNED

Cells continuously sense and interpret the external signals coming from their time-varying environments to generate context-dependent responses. This is true for the entire tree of life, ranging from bacteria and unicellular eukaryotes to neurons forming networks in the developing brain. Identifying the fundamental principles and underlying mechanisms that enable cells to interpret their complex natural surroundings and adequately respond remains one of the fundamental questions in biology. Conceptual views so far have been mainly guided by molecular biology descriptions, suggesting that cells are controlled by a genomic program executing a pre-scripted plan. Our goal is to develop an alternative conceptual framework: cells generate internal representations of their external ‘world’, which they utilise to actively infer information about it and predict changes, in order to determine their response. We will formalise this concept in a theory of single-cell learning, by combining information theory concepts to quantify the predictive information from the internal cell representations, with dynamical systems theory to explain how these encodings are realised. We will interrogate experimentally systems across all scales of biological organization: bacteria (B. subtilis), single-cell organisms (Paramecium, Tetrahymena) and neuronal cell culture models. By studying them in a comparative manner, we aim at identifying generic molecular mechanisms through which single-cell learning is realised. The acquired understanding will enable us to address in vivo how single neurons during D. melanogaster development learn to form, stabilize or eliminate axonal branches, to generate stereotyped synaptic patterning under highly-variable conditions. We argue that providing a broader and generic definition of learning will serve as a unifying framework, linking disparate areas and scales of biology, and offering a basis for addressing fundamental biological questions.

Keywords: cell learning and memory,information theory,synaptic targeting,recurrent networks,transient dynamics,aneural systems
Next-generation electric motor technology (FiberPrint400plus)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Norway
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

The global imperative for renewable energy calls for a shift from fossil fuel engines to electric motors. Ironless motors offer a promising path to lighter and more efficient designs, expediting the green transition. ALVA's FiberPrinting™ technique enables the world's most powerful, efficient, and low-cost ironless motors. Currently limited to low-voltage applications like drones, FiberPrinting must be made compatible with high-voltage to meet the needs of transportation and industry, which contribute 40% of global CO2 emissions. ALVA seeks €2M grant and €10M finance to adapt FiberPrinting for high voltage, targeting markets such as drone taxis, boats, and industrial robots. ALVA's investors are prepared to supplement any EIC funding. This collaboration can significantly cut global CO2 emissions while enhancing European electric motor capabilities. ALVA is building a green-tech company for the future. Join us in moving the world with electricity.

Keywords: electrification,manufacturing,transportation,electric machines,windings
Altitude-like hypoxia cognition training to target brain erythropoietin as a novel mechanism of long-lasting enhancement of neuroplasticity and cognitive functions (ALTIBRAIN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Denmark
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-12-01
End date: 2027-11-30
Duration (months): 60.0
Total project cost (EUR): 1999944.0
EU funding (EUR): 1999944.0
Participants: 3
Project status: SIGNED

Cognitive decline is an urgent strategic treatment target to improve the lives of people with neuropsychiatric disorders and reduce associated societal costs but treatments with robust and long-lasting efficacy are essentially lacking. Neuroplasticity is pivotal for cognitive functions and its disruption is involved in cognitive decline. However, the mechanisms underlying long-lasting neuroplasticity are unknown, which impedes the discovery of effective treatments. To address this challenge, I have conducted multidisciplinary research over the past 15 years into the cognitive and neurobiological effects of erythropoietin (EPO), a body-own protein involved in neurodevelopment, neuroprotection and cognition. We discovered that upregulation of EPO in the brain by low ambient oxygen increased neuroplasticity and cognition in mice. Building on this discovery, ALTIBRAIN will test a novel model linking oxygen manipulation, increased brain EPO, neuroplasticity and cognition. Specifically, ALTIBRAIN will determine whether upregulation of brain EPO by low ambient oxygen is a novel mechanism of long-lasting neuroplasticity and increased cognitive functions. We will achieve this ambitious goal using a multidisciplinary translational research approach combining cutting-edge methods from neuropsychology, neuroimaging and neuroscience. In parallel studies in humans and mice, we will investigate whether 3-week intermittent low ambient oxygen combined with cognitive training induces expression of brain EPO sufficient to produce similar effects to those, which I found upon exogenous EPO treatment. We expect long-lasting increase in cognitive performance, hippocampal volume and function and in differentiation/maturation of neural progenitor cells and dendritic spines. The findings can lead to a breakthrough in the understanding of mechanisms underlying enduring neuroplasticity and a paradigm shift in treatment strategies targeting cognitive decline.

Keywords: multidisciplinary,translational research,neuroimaging,cognitive impairments,cognitive training
Evaluation of thermohydraulic characteristic of printed circuit heat exchangers in pseudocritical region for supercritical CO2 cycle (Super-CO2)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-07-15
End date: 2026-07-14
Duration (months): 24.0
Total project cost (EUR): 226751.04
EU funding (EUR): 226751.04
Participants: 1
Project status: CLOSED

Currently, 28.2% of the total EU-28 greenhouse gas emissions come from the power sector, a large contributor to greenhouse gas emissions. Consequently, the emphasis of the research in power generation has swung towards assessing highly efficient and greener power cycles. In this reference, the novel supercritical carbon dioxide Brayton cycle (sCO2-BC) is an ideal choice that outstrips other formally well-known power cycles (Brayton & Rankine cycles). In sCO2-BC, the role of the pre-cooler is critical. It serves as a sink to the power cycle and regulates the conditions at the compressor's inlet. The compressor's inlet temperature is intended to be maintained close to the critical temperature of carbon dioxide (CO2) to achieve greater cycle efficiencies. However, exceptionally higher values of the specific heat capacity of CO2 near its critical point (up to 40 times higher than water) require exceedingly high water flow rates on the cold side to achieve the desired exit temperatures of CO2. Consequently, the pre-cooler's pumping power requirements become high enough to deteriorate the cycle's performance. This problem can only be mitigated by exploring new channel geometries with enhanced thermohydraulic characteristics. Therefore, the proposed study plan to characterize the complex thermohydraulic characteristics in the pseudocritical region of CO2 using a multifaceted technique that includes, experimental, numerical, and machine learning techniques. The proposed work will provide a step forward to the success of sCO2-BC technologies that, in turn, will facilitate its integration with the green energy resources (generation-IV nuclear reactors and solar concentrated plants), helping to meet the EU's 2030 climate and energy framework goals of achieving at least 32% share for renewable energy.

Keywords: heat transfer supercritical carbon dioxide brayton cycle precooler design,printed circuit heat exchangers design optimization machine learning
EVOLVE: Euro-BioImaging - Vision - Open Science - Landscape - Visibility - Excellence (EVOLVE)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Finland,Germany,Italy
Call: Consolidation of the RI landscape – Individual support for evolution and long-term sustainability of pan-European research infrastructures (HORIZON-INFRA-2023-DEV-01, 2023)
Start date: 2024-03-01
End date: 2027-08-31
Duration (months): 42.0
Total project cost (EUR): 5000000.0
EU funding (EUR): 4000000.0
Participants: 3
Project status: SIGNED

Euro-BioImaging ERIC is the ESFRI landmark to imaging excellence. It has completely changed the premises of European researchers by providing them with an open gateway to cutting-edge biological and biomedical imaging technologies, including access to expertise, data services, and training - all of which are essential ingredients for scientific breakthroughs and innovations to occur. Euro-BioImaging was established as an ERIC in December 2019 and since has grown quickly to currently 35 National Nodes representing 173 individual imaging facilities. 16 European countries and EMBL have committed to jointly operate this pan-European research infrastructure. The EVOLVE project, presented in this proposal, aims to significantly strengthen the young ERIC to reach its next level as a pan-European organization, and to live up to the needs and expectations expressed by its continuously expanding communities of users, partners, ERIC members, industry and other relevant stakeholders. Building on the EVOLVE project during the next 3,5 years, Euro-BioImaging will significantly strengthen its cost-efficient administration and set-up the next generation of its user access web portal. Furthermore it will foster the family of Euro-BioImaging Nodes and Hub at the personal, institutional, national and European level. The ERIC will implement a sustainable strategy for external relations with policy makers and funders, as well as boost its outreach and communication activities with new user communities for widening participation. An increased service offer, in particular for training (users and Nodes’ staff) and FAIR image data services will underpin excellence-driven user access and Open Science. Finally, EVOLVE will empower Euro-BioImaging facilities across Europe to underpin the Green and Digital Transition. With successful project conclusion Euro-BioImaging ERIC will have demonstrated the impact of this globally unique research infrastructure for European life sciences and beyond

Keywords: community engagement,training,data services,stakeholders,operation processes,green eric
Paracrine signalling in alpha cells and the integration of mechanisms that control glucagon secretion (ParaALPHA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-04-01
End date: 2028-07-31
Duration (months): 64.0
Total project cost (EUR): 1659836.0
EU funding (EUR): 1659836.0
Participants: 1
Project status: SIGNED

Diabetes is a common disease affecting millions of patients world-vide. The disease is characterised by hyperglycaemia, caused by reduced insulin signalling and release. Recent findings suggest that the hormone glucagon also plays a critical role. Glucagon is a counteregulatory hormone released form alpha cells in pancreatic islets, to increase hepatic glucose production. Diabetic and obese patients suffer from hyperglucagonaemia, which leads to inappropriate hepatic glucose production. Glucagon secretion is regulated by intrinsic and paracrine mechanisms. The intrinsic regulation rely on the effect of glucose on metabolism and the paracrine on secretion of hormones from neighbouring beta and delta cells. Paracrine signalling form insulin and somatostatin inhibits glucagon secretion through activation of Protein kinase B and inhibition of protein kinase A leading to lower electrical and exocytotic activity. Both kinases regulate transcription and metabolism in other tissues. I suggest that paracrine signalling also affect alpha cell metabolism to regulate glucagon secretion. My recent work show that alpha cells rely on fatty acids for ATP production and that the mechanism by which glucose inhibits glucagon secretion requires glucose to lower fatty acid oxidation. In this project, I will 1) investigate whether insulin and somatostatin signalling regulate metabolism and ATP production in alpha cells, 2) identify the underlying kinase signalling, and 3) explore the role of hyperglucagonaemia in diabetes. To understand the effect of insulin and somatostatin on alpha cell function and glucagon secretion, I will use dynamic measurements of kinase signalling, ATP levels, membrane potential and calcium in mouse and human islets. Combining this with genetically modified animal models, we will have the unique opportunity to study if dysfunction of both paracrine and intrinsic regulation of glucagon secretion is required for the development of hyperglucagonaemia in diabetes.

Keywords: glucagon secretion,paracrine inhibition,somatostatin,insulin,kinase signalling,glucose metabolism,fatty acid metabolism,islets of langerhans live cell imaging
Exploring bacterial multicellularity: study of long-distance metal transport and intercellular junctions in Actinosynnema mirum (SynneJunctions)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-01
End date: 2026-07-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

In recent decades, research has revolutionized the conventional view of bacteria as solitary entities suspended in liquid media. Bacterial multicellularity, which leads to the formation of complex structures such as biofilms that comprises diverse bacterial species, challenges the outdated paradigm. Even less is known about the multicellular bacteria capable of aerial growth, raising questions about their access to essential resources found only in the substrate inaccessible to them. This project focuses on the study of two closely related bacteria, Actinosynnema mirum and Actinosynnema pretiosum, which form tree-like structures known as synnemata. Data have revealed the presence of intercellular cell junctions, the functions of which remain elusive but undoubtedly important within synnemata. Additionally, metal distribution within the synnemata has been studied using nano X-Ray Fluorescence, indicating the presence of metals throughout the aerial mycelium and patterns of discrete, non-uniform intracellular metal concentrations. This project aims to challenge the existing model of long-distance metal transport in synnemata. It begins with the development of translational fusion reporters, labeling membrane transporters with mNeonGreen, coupled with confocal microscopy to assess the relevance of the proposed model, depicting a restrained spatial localization of the transporters at cell junctions. Advanced cryoEM techniques will also be used to better characterize the cell junctions within synnemata. By examining metal transport and distribution within these multicellular structures, this research aims to shed light on their intricacies and potentially revolutionize our understanding of how bacteria efficiently share essential resources over long distances. In summary, this project ventures into the fascinating world of bacterial multicellularity and resource-sharing mechanisms within synnemata, providing new insights into a novel aspect of bacterial life.
Motio iSocket: The World's First Bionic Socket (Motio iSocket)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Portugal
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

There is a combined population of 6.5 million amputees in North America and Europe, and this number is expected to double by 2050. Despite technological advancements in the last few years, there is a massive lack of exploiting data driven approaches in the prosthetics field. As a consequence, over 75% of amputees still suffer from pain or discomfort while wearing their prosthetic devices and have to undergo costly and inefficient adjustment. At the same time, patients suffer from prolonged claim reviews and high denial rates by healthcare insurances due to the lack of precise patient activity and functional data. What is urgently needed is a completely new approach to prosthetics – from subjective and experience-based adjustments that are based on trial and error to a true data-drive precision medicine approach, enhancing acceptance rates by health insurances and patient welfare simultaneously. At the core of Amparo is the development of the Motio iSocket, the world's first intelligent, self-adjustable prosthetic socket. Unlike traditional sockets, this bionic device demonstrates adaptability and real-time responsiveness. It is designed to automatically adjust itself to ensure an optimal fit in line with the activity the user is performing. The Motio iSocket is directly molded to the patient's residual limb ensuring an ideal fit. Importantly, it can also accommodate dynamic changes, being the first to address residual limb volume fluctuations throughout the day. This innovation is only made possible by our highly motivated and experienced team of 13 professionals. We strongly believe in the power of interdisciplinarity, combining experts from diverse fields. With almost 10 years of experience in the O&P industry, our team has a proven track record of creating and developing medical products, obtaining device certifications and approvals, thereby fostering development in accordance with EN ISO 13485:2016 standards.

Keywords: prosthetics data bionics adjustability healthcare