Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Bioinspired Singlet Fission Photon Multipliers (BioSinFin)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Spain,Italy,Sweden
Call: EIC Pathfinder Open (HORIZON-EIC-2024-PATHFINDEROPEN-01, 2024)
Start date: 2025-04-01
End date: 2029-03-31
Duration (months): 48.0
Total project cost (EUR): 2997801.25
EU funding (EUR): 2997801.25
Participants: 7
Project status: SIGNED

The European Union (EU) Revised Renewable Energy Directive 2023/2413/EU states the need of advancing renewable energy sources to meet the commitments of the Paris Agreement while keeping the EU a global leader in renewables. Among the existing renewable energy technologies, photovoltaics are one of the most mature, promising to reach a worldwide production of 8,519 GW by 2050. Silicon-PVs (Si-PVs) are the most advanced approach to reach the above goal at low costs. However, they still face the problem of thermalization, an energy loss mechanism by which the excess energy of the absorbed photons with respect to the Si band gap is lost. BioSinFin will tackle this issue developing the first bioinspired photomultiplier coating based on singlet fission, a multiple exciton generation process. Here, singlet-fission active chromophores and red-emitting materials are bioconjugated to protein scaffolds with nm precision and used to fabricate a coating to sensitize Si solar cells promising up to an additional 5% to the absolute power conversion efficiency of commercial Si PVs (i.e. about 25% improvement) using a low-cost and sustainable coating, leading a revalue of Si-PV market of up to 15%. This multi-photon protein family and its respective coatings will allow to realize a low-cost, sustainable, environmentally friendly, and highly performing new generation of multi-photon low-energy bio-hybrid emitters of great interest for photonics with a final proof on overcoming thermalization in silicon solar cells, helping the EU to fulfil the Revised Renewable Energy Directive.

Keywords: singlet fission,photomultiplier coatings,biomaterials,multifunctional artificial fluorescent proteins,bio hybrid photonics
Gravity Beyond Einstein: Gravitational-Wave Signatures of New Physics (EFTGrav)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-09-01
End date: 2031-08-31
Duration (months): 60.0
Total project cost (EUR): 1501250.0
EU funding (EUR): 1501250.0
Participants: 1
Project status: SIGNED

The detection of gravitational waves (GWs) from binary black holes (BBHs) allows us to test the predictions of General Relativity (GR) in a highly-warped regime for the first time in history. Input from fundamental physics indicates that GR is not a complete theory, and therefore it must undergo modifications that would become relevant in extremely powerful gravitational fields. The next generation of GW observatories will probe extreme gravitational phenomena with a new level of precision, and hence opens a new window to observe the effects of these modifications. This project will describe the most relevant smoking-gun signatures of modifications of GR on GW observations of BBHs, therefore enabling the experimental search of new physics. By working within the framework of effective field theory (EFT) —which captures the most general modifications of GR in an agnostic way — we will analyze the impact of beyond-GR physics on several key observables. We will provide a thorough analysis of the quasinormal modes (QNMs) of black holes — which control the ringdown part of the GW signal — introducing a novel formulation of perturbation theory as well as a correspondence between QNMs and modified geodesics. We will obtain the QNM frequencies of black holes of arbitrary rotation (including the challenging case of highly rotating black holes) and we will also analyze the amplitudes of QNMs. This will allow us to accurately model the ringdown signal and to identify resonances that would amplify the effects of new physics. We will also describe the inspiral of a BBH in the EFT extension of GR, accounting for corrections to radiation reaction and tidal effects — which we will analyze in detail by determining the tidal deformability of rotating black holes. In this way, we will obtain inspiral waveforms for spinning BBHs beyond GR. Our results will make it possible to perform precision tests on modifications of GR with the next generation of GW observatories.

Keywords: higher derivative gravity,black hole perturbation theory,binary black holes
Engineered control of cellular circuits (E-CTRL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1494669.0
EU funding (EUR): 1494669.0
Participants: 1
Project status: SIGNED

Protein signaling in cells is precisely coordinated in space and time. Molecular chemogenetics, optogenetics, and biosensors have generated a scientific revolution enabling the spatiotemporal codes of protein signaling in single cells. However, it is a great challenge to study protein dynamics in a physiological multicellular environment due to the extensive variability in protein signaling within individual cells, as well as the sparsity of driver cells responsible for a specific physiological process. To build causal relationships between proteins and multi-cellular behavior, we will develop broadly applicable technologies by engineering proteins enabling the control of target proteins with light, exclusively in the relevant driver cell subpopulations. These approaches can be used in any biological field in which protein signaling is critical for multi-cellular behavior, but here we will focus on three different stages of a challenging neurobiology process. Upon sensory experience, for example, by learning a new task, only the subsets of neurons within a corresponding brain region switch to the active state. It is largely unknown how proteins that are activated in these sparsely activated neuronal circuits operate in space and time. Our technologies will enlighten the spatiotemporal dynamics of proteins in active neuron subpopulations responding to certain learning tasks in mice. Understanding such learning neuronal circuit responses at the molecular level will pave the way to develop new therapeutic approaches for brain disorders including epilepsy, depression, and autism spectrum disorders.

Keywords: biosensors,molecular optogenetics,chemical biology,protein engineering,protein switches,engineered allostery,neural circuits,synaptic plasticity,cellular circuits
Novel histocompatibility loci in man (Histogenomics)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2024-09-01
End date: 2029-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Allogeneic tissue graft (hematopoietic cell transplantation; HCT) and solid organ transplantation (SOT) (Kidney, Heart, Lung,..) save tens of thousands of lives annually. Yet their success is compounded by a high incidence of the potentially fatal graft-versus-host disease (GvHD) in HCT and chronic rejection (CR) in SOT. This is primarily due to the existence of yet unknown histocompatibility loci which have escaped detection - besides certain immunogenic peptides - since the identification of the Major Histocompatibility Complex (MHC; also called Human Leukocyte antigen “HLA” in man) in 1940-1950s. The identification of these hitherto unknown histocompatibility loci in man is the major aim of this proposal. Our contribution to MHC genetics includes the identification of the sole, non-HLA, MHC-encoded, class I molecules; the MHC class I chain-related MIC genes (A second lineage of mammalian major histocompatibility complex class I genes. | PNAS), which we recently qualified as a bona fide histocompatibility gene (The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation | Nature Medicine). Here we aim to identify the totality of histocompatibility loci embedded within our genome. We will apply a pluri-omics approach (successfully applied elsewhere Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort (science.org)) on deeply phenotyped cohorts of kidney transplants and HCT. Identified candidate loci will be validated based on their ability to be presented by MHC molecule and to elicit T- and/or B-cell responses. In contrast to the classical, hypothesis-driven approaches, which have collectively failed to identify universally applicable such loci in the past 70 years, our approach is unbiased, data-driven and unprecedented in the field. It shall have direct relevance in our understanding of the primum movens of GvHD and CR and shall lead to a personalized therapy of the transplant patient.

Keywords: major histocompatibility complex,hla,histocompatibility,kidney transplantation,hematopoietic cell transplantation,graft versus host disease
Genetically Engineering Experimental Models: Enhancement of Scientific and Technological excellence and innOvation potential to study NEurodevelopmental diseases (GEMSTONE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Türkiye,Sweden,Italy
Call: Twinning (HORIZON-WIDERA-2021-ACCESS-03, 2021)
Start date: 2022-10-01
End date: 2025-12-31
Duration (months): 39.0
Total project cost (EUR): 1450446.45
EU funding (EUR): 1450446.45
Participants: 3
Project status: SIGNED

Acibadem Mehmet Ali Aydinlar University (ACU) is a thematic university in the field of health sciences in Turkey. GEMSTONE will advance ACU's scientific research and innovative capacity in strategic areas of gene engineering technologies and neuroscience with focus on the neurodevelopmental aspects of brain disorders, such as Parkinson’s disease and epilepsy. GEMSTONE will strengthen collaboration with and capitalizing on knowledge transfer from one high-ranking foreign European academic institution (ULUND) and one non-profit organisation (ICONS). GEMSTONE will create opportunities for bilateral exchange of scientific knowledge and technical skills and training opportunities for researchers in hard and soft skills, supported by naturally convergent research interests. The project will result in increased scientific productivity, more active participation of ACU in national/international conferences and grants, and new networking and collaboration opportunities, which will increase the attractiveness, competitiveness and visibility of ACU within the global neuroscience community. A second pillar in the project will ensure that ACU researchers are adequately supported to express their potential. Staff of ACU Research Project Office and other research support services will be provided with the necessary knowledge and skills to guide researchers in submitting successful grant applications, attracting funds, communication research results and translating them to clinics and/or in commercial products. Lessons learned in the performance of research and in research management and administration will be collected in a best practice book and disseminated to other universities and governments in Widening countries. Ultimately, by increasing ACU researchers’ scientific profile and ACU research management, administration and communication capacities, the project will decrease the disparities among ACU and the top-class leading counterparts at the European level.

Keywords: genetically engineered experimental models gems,transgenic animal,neurodevelopment,absence epilepsy,parkinson s disease,
Cloud-aERosol inTeractions & their impActs IN The earth sYstem (CERTAINTY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Research and Innovation actions
Countries involved: France,Finland,Greece,Germany,Ukraine,Switzerland,United Kingdom,Spain,Netherlands,Sweden
Call: Improved knowledge in cloud-aerosol interaction (HORIZON-CL5-2023-D1-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 7213742.68
EU funding (EUR): 7213742.68
Participants: 19
Project status: SIGNED

Cloud, aerosols and their interactions are key regulators of climate. However, uncertainties in the magnitude of the net cooling impact of aerosols on climate and in the cloud response to evolving anthropogenic emissions and climate change induced feedbacks on natural emissions are major challenges that limit our understanding of how global and regional climate, including extremes, respond to changes in greenhouse gases. It is of paramount importance to better understand aerosol-cloud processes and their role in the Earth System, from regional to global scales, and over different time scales, from days to decades. Over the last decade, extensive research networks, infrastructures, satellite instruments, and atmospheric models have been developed, making it possible to obtain a holistic view of the effects of clouds and aerosols on climate and weather. CERTAINTY will capitalise on this available data together with advanced algorithms, machine learning and data assimilation methods, high resolution models, and Earth system models to bring the fundamental knowledge of interactions between clouds, aerosols, and radiation to a new level. The consortium partners are in key roles as operators, data originators, developers, providers, and users of European aerosol and cloud data and ESMs/high resolution models. The consortium leads the activities of next generation satellite missions (such as EarthCARE), and the development of new satellite products, to facilitate their scientific use in CERTAINTY by preparing tools for early adoption of data. CERTAINTY will bring the observation-based knowledge to be used in modeling frameworks to improve predictive models and knowledge of processes controlling aerosols, clouds, and their interactions from hours to decades. The ultimate outcome will be better understanding and predictions of extreme events that facilitates planning of climate mitigation/adaptation strategies for the good of European citizens and global society.

Keywords: cloud,aerosols,interactions,weather,climate,satellite,observations,models,data assimilation,radiation,advanced algorithms
Automorphic Forms and Arithmetic (AuForA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 1956665.0
EU funding (EUR): 1956665.0
Participants: 1
Project status: SIGNED

This proposal is at the interface of number theory and automorphic forms and aims at a cross-fertilization of both areas. It focuses on explicit arithmetic problems that can be solved using the full force of the automorphic machinery. Conversely it develops the theory of automorphic forms in higher rank using number theoretic methods. At the core are three sets of deep and longstanding open conjectures in higher rank cases: - the joint equidistribution conjectures of Michel and Venkatesh concerning the distribution of pairs of shifted CM points, - the “beyond endoscopy” program of Langlands of identifying functional lifts by a comparison of different trace formulae, - the density and optimal lifting conjectures of Sarnak concerning the behaviour of exceptional eigenvalues, and their arithmetic consequences. The key objects are certain Shimura varieties associated to abelian varieties, higher rank Kloosterman sums, families of L-functions, trace formulae and Hecke eigenvalues. By an interdisciplinary combination of analytic number theory and automorphic forms, the proposal aims at definitive progress and solutions to these three conjectures, each of which has been open for at least 15 years.

Keywords: automorphic forms,analytic number theory,trace formulae,equidistribution,l functions,beyond endoscopy,kloosterman sums,density theorems
Centre of Excellence for Precision Medicine in Pediatric Care (PMPC)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Life Sciences
Countries involved: Latvia,Netherlands
Call: Teaming for Excellence (HORIZON-WIDERA-2023-ACCESS-01, 2023)
Start date: 2025-01-01
End date: 2030-12-31
Duration (months): 72.0
Total project cost (EUR): 14400000.0
EU funding (EUR): 14400000.0
Participants: 2
Project status: SIGNED

The vision of the PMPC (“Centre of excellence for precision medicine in pediatric care”) project is to position the Children’s Clinical University Hospital (CCUH) in Latvia at the leading-edge of pediatric precision medicine research and care in Europe. Precision medicine has proven its potential to revolutionize healthcare by tailoring treatments to individual patients based on their unique genetic makeup, environment and lifestyle factors. While it has shown promise and delivers results in adult populations, its potential in pediatric care is largely untapped. Our goal is to improve pediatric patient care and outcomes by establishing a new research Centre of Excellence (CoE) at CCUH’s campus for research on and adoption of innovative precision medicine approaches in an integrated and collaborative RESEARCH +INNOVATION+CARE+EDUCATION (“R+I+C+E”) environment. To this end, CCUH will team-up with Europe’s leading institute in pediatric precision medicine: the Princess Maxima Center, The Netherlands. Maxima has an extensive precision medicine program and uses advanced translational research and treatment expertise in many areas, including CAR-T cell therapies and pediatric clinical trials. The CoE will provide an environment for transdisciplinary team science with international visibility in the field of pediatric precision medicine. The center will leverage the latest advances in genomics, cell therapies, data science, and computational biology. CCUH has secured 20 million EUR from private donors as a complementary part of funding. Together with the Horizon Europe grant, the valuable knowledge/technology transfer and active collaboration with the Maxima team, PMPC’s unique value will be brought forward resulting in benefits for patients, their caregivers, researchers, healthcare professionals and society. It will strengthen CCUH’s scientific and technological capacity in precision medicine, enabling it to attain a competitive position in this promising field.

Keywords: precision medicine,molecular diagnostics,targeted treatments,pediatric care,pediatric oncology and rare diseases,cell therapies,car t cells,clinical research,genomics,transdisciplinary
ORU BASED ON BUILDING BLOCKS FOR ADVANCED ASSEMBLY OF SPACE SYSTEMS (ORU-BOAS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Spain,France,Italy,Netherlands,Germany,Belgium
Call: Future space ecosystems: on-orbit operations, new system concepts (HORIZON-CL4-2021-SPACE-01, 2021)
Start date: 2023-01-01
End date: 2024-12-31
Duration (months): 24.0
Total project cost (EUR): 1969335.0
EU funding (EUR): 1969335.0
Participants: 6
Project status: CLOSED

ORU-BOAS (ORU based on Building Blocks for On Orbit Advanced Assembly of Space Systems) project will develop and demonstrate an ORU concept (TRL 6) based on the Building Blocks developing in previous SRC calls and PERASPERA/EOF objectives. The main points to be developed are: - An ORU compatible with the different SI, payloads and services as indicated in the topic reaching finally a TRL 5/6 - This ORU to be used as "plug&play" module for the topic HORIZON-CL4-2022-SPACE-01-11 (In Orbit Demonstration phase) - To develop a Satellite Construction Kit user cases for future application in ISMA (In Space Manufacturing and Assembly) missions - The ORU design concept will include an AppStore and Open-Architecture mentality for the different modules as avionics. The ORU will be designed in a modular concept in order to be flexible and provide capabilities to upgrades in an efficient manner. This project will consider the needs and requirements of current PERASPERA projects: EROSS+ and PERIOD. The ORU-BOAS consortium is formed by SENER Aeroespacial (coordinator), Thales Alenia Space France, Thales Alenia Space Italy, ISISPACE and DLR. This consortium has a considerable experience in previous PERASPERA projects: SENER was coordinator of OG5 SIROM and Thales Alenia Space France coordinated OG4 I3DS, OG7 EROSS and OG12 EROSS+. Rest of participants have contributed also to these and others PERASPERA projects: PULSAR, MOSAR, ADE, ... SENER and ISISPACE are currenty working in PERIOD.

Keywords: oru,modularity,scalability,standard interface,building block,sirom,appstore,satellite construction kit