Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Stem-cell based gene therapy for recombination deficient SCID (RECOMB) (RECOMB)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Italy,Spain,Italy,Israel,Germany,Poland,France,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: New therapies for rare diseases (H2020-SC1-2017-Two-Stage-RTD, 2017)
Start date: 2018-01-01
End date: 2024-12-31
Duration (months): 84.0
Total project cost (EUR): 5990460.75
EU funding (EUR): 5990460.0
Participants: 17
Project status: SIGNED

Gene therapy for rare inherited immune disorders has become a clinical reality. Especially for SCID, two major types of SCID (ADA-SCID, X-SCID) have been successfully treated by autologous stem cell based gene therapy. However, for the most common group of SCID, the SCID underlying recombination defects, this has not yet occurred due to the higher complexities of the affected genes involved. The aim of the current proposal is to fill the unmet medical need for the most common major category of SCID, recombination activating gene-1 (RAG-1) deficient SCID, by performing Stage I/II clinical trials using autologous hematopoietic stem cell based gene therapy. To this end we will develop novel safety assays, pre-GMP and GMP lentiviral batches and design and conduct multicenter, multinational clinical trials with input from regulatory authorities such as EMA and patient advocacy groups. The trial will be conducted with phenotypic, molecular (integration sites, therapeutic gene expression) and functional readouts and should lead to effective treatment for > 70% of all SCID patients in Europe. RECOMB forms the logical extension of highly successful previous EU consortia that have made the EU global leader in gene therapy for orphan immune diseases.

Keywords: gene therapy
Medicine, Immortality, Moksha: Entangled Histories of Yoga, Ayurveda and Alchemy in South Asia (AYURYOG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Austria,Canada,United Kingdom
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-06-01
End date: 2020-05-31
Duration (months): 60.0
Total project cost (EUR): 1416146.0
EU funding (EUR): 1094737.25
Participants: 3
Project status: CLOSED

The project will examine the histories of yoga, ayurveda and rasashastra (Indian alchemy and iatrochemistry) from the tenth century to the present, focussing on the disciplines' health, rejuvenation and longevity practices. The goals of the project are to reveal the entanglements of these historical traditions, and to trace the trajectories of their evolution as components of today's global healthcare and personal development industries. Our hypothesis is that practices aimed at achieving health, rejuvenation and longevity constitute a key area of exchange between the three disciplines, preparing the grounds for a series of important pharmaceutical and technological innovations and also profoundly influencing the discourses of today's medicalized forms of globalized yoga as well as of contemporary institutionalized forms of ayurveda and rasashastra. Drawing upon the primary historical sources of each respective tradition as well as on fieldwork data, the research team will explore the shared terminology, praxis and theory of these three disciplines. We will examine why, when and how health, rejuvenation and longevity practices were employed; how each discipline’s discourse and practical applications relates to those of the others; and how past encounters and cross-fertilizations impact on contemporary health-related practices in yogic, ayurvedic and alchemists’ milieus. The five-year project will be based at the Department of South Asian, Tibetan and Buddhist Studies at Vienna University and carried out by an international team of 3 post-doctoral researchers. The research will be grounded in the fields of South Asian studies and social history. An international workshop and an international conference will be organized to present and discuss the research results, which will also be published in peer-reviewed journals, an edited volume, and in individual monographs. A project website will provide open access to all research results.

Keywords: south asian cultural history,medical history,entangled histories,global history,transnational history,medieval and early modern history,colonial and post colonial history
Fate and impact of past, present and future consumer plastic on soil (SoPla_Fate)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany,Australia
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 252876.48
EU funding (EUR): 252876.48
Participants: 2
Project status: SIGNED

Soil provides us with 98.8% of our food and by 2050 we need to increase the production by 70%; yet our soils are degrading. Soils were recently recognised as a sink for plastic. This is particularly of concern for agricultural soil health due to extensive and increasing plastic use in farming such as plastic mulching and unintentional plastic introduction through biosolid applications. Based on plastic persistence, widespread use and recent results in soil eco toxicology and eco system effects, plastic has been proposed as driver of global change. However, critical data to clarify the impact of plastic on soil health is currently lacking. This project employs a multidisciplinary approach to determine the extent of plastic contamination in agricultural soils as well as the fate of plastic and its impact on soil processes while providing training and knowledge gain that will be transferred to the EU and further exploited. SoPla_Fate will address the current knowledge lack by (1) quantifying the polymer distribution and concentration in different agricultural soils. Polymer properties including size, shape and surface area will be quantified for representative samples. (2) State-of-the-art analytical instruments and workflows will be employed for the fingerprinting, screening and identification of plastic additives. (3) The workflows will further be employed to determine the leaching and partitioning behaviour of additives from plastic and aged plastic into the soil environment. (4) The impact of different plastic aspects such as polymer type, additive composition and aging induced changes to polymers and plastic on vital soil processes will be quantified. The outcomes from SoPla_Fate will advance our assessment of potential soil health impairment though plastic pollution highlighting the importance of an integrated multidisciplinary research connecting plastic fate in soil with its impact.

Keywords: consumer plastic,plastic additive behaviour,additive screening,fingerprinting,consumer plastic aging,soil cores,vital soil processes
Cultural exchanges, network and community in early humanist Europe. The case of Aeneas Silvius Piccolomini (EuroCult)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 237768.0
EU funding (EUR): 237768.0
Participants: 2
Project status: SIGNED

EuroCult, a three-year research project to be developed at the universities and research centers of Toronto and Turin, will study the wide-ranging networks of Aeneas Silvius Piccolomini (1404-1464), one of the most important humanists of early fifteenth-century Europe. Piccolomini was a man of many talents who inhabited multiple spheres: as a layman he was present at the Council of Basel, secretary to the antipope and the Emperor, then become bishop, cardinal and eventually pope himself. During his life he wrote many dialogues, historical works, and hundreds of letters, making himself the hub of an extensive European literary and political web. This research aims to demonstrate that Piccolomini, who played a significant role in practical political affairs both locally and internationally as the emperor’s legate and as pope, can be viewed as an important contributor to shifting cultural approaches at a European level. He had a rich and vibrant personal and professional network of intellectual contacts with whom he exchanged ideas and books, received informal feedback on his work, and discussed cultural, religious and political questions. EuroCult will reconstruct the cultural, political and religious spheres of which he was a part, investigating his networks and communities of learning, and his role as cultural model in the use of Latin in early Renaissance Europe and later.

Keywords: early renaissance,latin,rhetoric,cultural exchanges,cultural models
enhancing Innovation and Key Account Management by sme2EU (I-KAM2EU)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Italy,Italy,Italy,Italy,Italy
Call: Enhancing the innovation management capacity of SMEs (H2020-Adhoc-2014-20, 2014)
Start date: 2015-01-01
End date: 2016-12-31
Duration (months): 24.0
Total project cost (EUR): 225353.1
EU funding (EUR): 225353.1
Participants: 9
Project status: CLOSED

The proposal aims at providing the two new Enterprise Europe Network services: 1) Enhancing SME’s Innovation Management Capacity (EIMC) for innovating SMEs, and 2) Key Account Management (KAM) for SME Instrument beneficiaries in the three Italian regions covered by the EEN consortium “SME2EU”: Tuscany, Marche and Umbria. These new services will be provided in an additional but integrated way to the usual EEN activities related to the SME competitiveness and innovation. The objective of the I-KAM2EU proposal is to improve the innovation management capacity of SMEs in order to enhance their competitiveness. The establishment of an internal innovation management system will allow the SMEs to become more innovative and to achieve more success with their product, service and process. This would foster SME’s results, value and competitiveness. SMEs are often not able to adequately develop their management innovation systems and there are no local available services that help them to go in this direction. The proposal will establish services to make available the opportunity for a SME to have a rational and structured support to develop and maintain an internal innovation management system Moreover, I-KAM2EU will support the SME Instrument beneficiaries to enhance the probability of successful exploitation of their project and to leave a footprint for the their future sustainable growth. The EICM service is targeted to a number of selected SMEs who are developing innovative products or services and with high potential for international competitiveness, but who have poor knowledge or skills or ability to manage the innovation processes. The partners agreed to make use of “IMP³rove” as core tool for the assessment phase of the service. The KAM service is reserved to SME Instrument Phase 1 or Phase 2 beneficiaries located in the three Italian regions covered by the proposal. I-KAM2EU will provide 83 EIMC and 13 KAM services for a total of 96 services in 2015-2016.

Keywords: innovation management,assessment,improvement,sustainable growth,enterprise europe network,sme instrument,coaching
Virus-X: Viral Metagenomics for Innovation Value (Virus-X)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Iceland,Norway,Poland,Sweden,Norway,France,France,Netherlands,United Kingdom
Call: Metagenomics as innovation driver (H2020-LEIT-BIO-2015-1, 2015)
Start date: 2016-04-01
End date: 2020-03-31
Duration (months): 48.0
Total project cost (EUR): 7964214.5
EU funding (EUR): 7964092.5
Participants: 17
Project status: CLOSED

Biological sequence diversity in nowhere as apparent as in the vast sequence space of viral genomes. The Virus-X project will specifically explore the outer realms of this diversity by targeting the virosphere of selected microbial ecosystems and investigate the encoded functional variety of viral gene products. The project is driven by the expected large innovation value and unique properties of viral proteins, previously demonstrated by the many virally-derived DNA and RNA processing enzymes used in biotechnology. Concomitantly, the project will advance our understanding of important aspects of ecology in terms of viral diversity, ecosystem dynamics and virus-host interplay. Last but not least, due to the inherent challenges in gene annotation, functional assignments and other virus-specific technical obstacles of viral metagenomics, the Virus-X project specifically addresses these challenges using innovative measures in all parts of the discovery and analysis pipeline, from sampling difficult extreme biotopes, through sequencing and innovative bioinformatics to efficient production of enzymes for molecular biotechnology. Virus-X will advance the metagenomic tool-box significantly and our capabilities for future exploitation of viral biological diversity, the largest unexplored genetic reservoir on Earth.

Keywords: metagenomics,bioinformatics,structural biology,microorganisms,virus,virome,virosphere,bioprospecting,ecosystem,bacteriophage,gene,orphan gene,homology,enzyme,polymerase
The role of ciliary tip organization in hedgehog signaling (CiliaryTip)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Cyprus
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-01
End date: 2022-06-30
Duration (months): 24.0
Total project cost (EUR): 145941.12
EU funding (EUR): 145941.12
Participants: 1
Project status: CLOSED

Cilia are microtubule-based organelles with essential motile, sensory and signaling functions. The cilium structure is important for its function however the mechanisms underlying the structure-function relationship are not well understood. The proposed study will address the role of the cilium structure in hedgehog signaling, one of the main cilia-based signaling pathways, essential for embryonic development and implicated in disease. In mammals, cilia are required for hedgehog signaling and the localization of signaling proteins at the distal end of cilia, the ciliary tip, is important for pathway activation. Structural defects at the ciliary tip affect the localization of signaling proteins and pathway activation and cause a subset of cases of Joubert Syndrome. We propose an unbiased and comprehensive approach to elucidate how the ciliary tip organization supports the localization and dynamics of hedgehog signaling proteins at this compartment. This work will impact how we address hedgehog related diseases in the future and will generate insights with broader implications with respect to the signaling and sensory roles of cilia. The fellow will conduct this work in the laboratory of Dr. Skourides at the University of Cyprus, a group with a consistent record of high quality publications, including important findings related to cilia. The Fellow’s experience in studying the ciliary tip in motile cilia and the expertise of the host in cellular and developmental biology ensure the successful implementation of the proposed work. The Fellow has demonstrated great potential in becoming an independent scientist by securing funding for her PhD work and receiving the Seal of Excellence on an MSCA-IF submitted in 2018. Through this fellowship the researcher will acquire both the training and experience that will allow her to transition to an independent career focused on the connection between cilium structure and function and its role in vertebrate development.

Keywords: primary cilia,ciliary tip,hedgehog signaling,microtubules
Macaronesia's Researchers' Night (MACARONIGHT II)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Spain,Spain,Spain,Portugal,Portugal
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-06-01
End date: 2021-03-31
Duration (months): 10.0
Total project cost (EUR): 301861.25
EU funding (EUR): 220045.0
Participants: 6
Project status: CLOSED

Macaronesia is a biogeographical region of five archipelagos in the Atlantic Ocean of which four are inhabited: Azores (Portugal), Canarias (Spain), Madeira (Portugal) and Cape Verde (Cape Verde). These islands share common geographical traits and challenges, and have undergone a similar history since the beginning of the 15th century when they were discovered by Portuguese and Spanish sailors. Once major strategic outposts now they are the Outermost Regions of the EU (except Cape Verde, which declared its independence from Portugal in 1975). The population of Macaronesia is around 3 million inhabitants, corresponding to the size of a smaller EU country. The overall objective of this project is to organise a shared Researchers’ Night for the Macaronesia Region connecting the population of these remote islands under the umbrella of the universal language of science. MacaroNight II aims at creating overall public awareness of science, research and innovation, especially in areas where the Region has outstanding performance even by international comparison. The main theme for MacaroNight 2020 will be a “Window to the Atlantic” creating visibility the work of scientists who are in the frontline of the battle fought against global environmental challenges working in some of the most vulnerable ecosystems of the world. By increasing visibility and international recognition of the work of scientists from the region MacaroNight II will have long-lasting beneficial impacts that could extend beyond the immediate objectives of the project.

Keywords: outermost regions
Cities as mobility hubs: tackling social exclusion through ‘smart’ citizen engagement (SMARTDEST)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Inclusive societies
Action type: Research and Innovation actions
Countries involved: Austria,Spain,Italy,Italy,Israel,Italy,Spain,Slovenia,Netherlands,Netherlands,United Kingdom,Portugal
Call: Innovative solutions for inclusive and sustainable urban environments (H2020-SC6-TRANSFORMATIONS-2019, 2019)
Start date: 2020-01-01
End date: 2023-09-30
Duration (months): 45.0
Total project cost (EUR): 3010794.54
EU funding (EUR): 3010794.54
Participants: 13
Project status: SIGNED

The SMARTDEST project tackles the societal challenge of social inclusion and sustainability in European cities by developing innovative solutions in the face of the conflicts and externalities that are emerging as a result of new forms of ‘mobile dwelling’. These encompass the rising cost of living, housing shortages, congestion of public services, the dislocation and marginalisation of low-income workers, and the transformation of place identities; all factors that point at avenues of exclusion of the most vulnerable sectors of resident communities. Faced with this, SMARTDEST’s overarching aim is to contribute towards urban policy agendas which take tourism and its social effects seriously. Its ambition is to fill a knowledge gap about the effects of tourism mobilities on urban inclusion and cohesion, and about the contextual, political and technological factors that determine fundamental variations in such effects; and to explore, design and test the validity of potential innovative pathways to mitigate social exclusion. The project thus includes 4 research packages that respectively (1) analyse tourism mobilities and mobile dwelling as transformative force-fields for places; (2) excavate social exclusion issues and coping practices through the engagement with affected communities in case study cities; (3) develop CityLabs as sites for the design of people-based and place-based solutions (both in the digital and non-digital realm) which demonstrate value for the broad ‘destination ecosystem’ of case study cities, and scale up as innovative systems of governance; (4) transfer the insights gained by the project at local level and extend their impacts through a dialogue with policy entities, concern communities, innovators and scientists throughout the EU policy space. The project is implemented by a consortium of 12 partners from 7 EU countries and 1 associated country, covering a broad range of academic skills; and engages with 8 case study cities.

Keywords: urban areas,social exclusion,mobilities,tourism,destinations,externalities,smart cities,urban governance