Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deciphering the tumor-immune-microenvironment profile and organization within the tumors of melanoma patients undergoing immunotherapy (MelImmuneOrg)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Israel
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 185464.32
EU funding (EUR): 185464.32
Participants: 1
Project status: CLOSED

Cancer progression is a complex process that depends on the interplay between tumor cells, tumor microenvironment, and the immune system. Inhibiting immunosuppression is beneficial for cancer patients. Although these therapies are promising they are successful only in part of the patients. Tumors are composed of distinct cell types with different phenotypes, that influence the efficacy of immunotherapies. Therefore, in order to better understand tumor biology and response to treatment, it is necessary to profile protein expression while preserving spatial information. Multiplexed Ion Beam Imaging by Time of Flight (MIBI-TOF) is a method in which antibodies conjugated to metals are used to simultaneously visualize dozens of proteins in intact tissue specimens by secondary ion mass spectrometry. Here we suggest to uncover the immune profile and organization within the tumors of melanoma patients undergoing immunotherapy using MIBI-TOF. My first objective is to characterize the tumor-immune microenvironments to understand how these are structured across patients and discover predictive features of response to immunotherapies. My second objective is to analyze the intratumor heterogeneity (ITH) of melanoma patients by exome sequencing. I will examine whether there are genetic correlates between ITH, immune microenvironment and response to therapy. Finally, my third objective will be the manipulation of individual hits to test their functional significance in tumor-immune architecture in murine models. By joining Dr. Keren’s lab that masters the MIBI-TOF technology, I will acquire this state-of-the art technique, as well as develop lab management and organization skills, and I will meet leader scientists from the immune-oncology field. This proposal will promote my competitiveness to gain an independent researcher position.

Keywords: multiplex imaging,melanoma,immunology,immunotherapy
Explore the potentialities of living implants for medical devices (IMPLANTaLive)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-04-01
End date: 2018-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

IMPLANTaLive coating technology provides an exciting business opportunity. IMPLANTaLive offers unique advantages of societal and economic importance such as public health and sick leave. Living, dynamic coatings for medical devices, ie. coatings with proper cell response upon implantation, are attractive for restoring body function. Conventional implant coatings are of inferior quality and therefore the majority, if not all, biocoatings fail in suitably interacting with host tissue. This poor performance of existing biocoating technologies is mostly caused by inherently static properties of surface coating, which disturbs the inherently dynamics between cells and surroundings, disrupting healthy tissue response and eventually causing adverse reactions like infections. Living coatings are produced by an innovative one step pre-conditioning of FDA approved polymeric and metal surfaces. Living non-pathogenic bacteria with GRAS status are suitable for in-vivo use, which provide medical devices with dynamic and responsive characteristics. Dynamic IMPLANTaLive coatings provide bidirectionality, ie. the ability to process biological stimuli by cellular control feedback loops and hence influence cellular and tissue characteristics and responses. This greatly enhances the application potential as the living coating can be easily tailored to the specific needs of a patient. IMPLANTaLive coatings can actively stimulate the reconstruction or injured site by releasing specific growth factors (relevant for ligament and tendon repair) or express membrane bound endothelial cell specific adhesion proteins (relevant for vascular devices). A business case will be developed for IMPLANTaLive covering different markets and routes for market introduction. Results of market analysis and financing needs will be combined with science-based technology comparison and used for discussions with potential industry partners. Several companies have already expressed interest in IMPLANTaLive.

Keywords: coatings,medical devices,living,chemistry
Recyclable Metal-free Photocatalysts for Synthetic Chemistry based on Covalent Organic Frameworks (PHOTOCATALYSIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2022-08-03
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

The discovery of smart and highly efficient catalysts for solar energy conversion and green fuel production is a global scientific challenge due to increasing energy demand and related environmental consequences. Synthetic photocatalysis is highly promising, but employs to date expensive and/or toxic metals, such as Pt, Au, Ru, Cd, Ag, and Ir. This hampers the development of large-scale and introduces environmental issues. The aim of this proposal is to develop stable, recyclable and metal-free heterogeneous photocatalysts for the Diels-Alder (D–A) reaction. D–A reactions are one of the most powerful synthetic protocols for the synthesis of unsaturated six-membered rings, yet to be well established for the industry. Herein, we selected porous organic polymers, namely Covalent Organic Frameworks (COFs) and Covalent Triazine Frameworks (CTFs), because they allow synergistic utilization of their skeleton and pores. Due to their high porosity and uniform pores, they allow for confined space synergies and easy mass transport. The pi-species in these catalysts are highly photo-catalytically active. These metal-free insoluble-polymer-catalysts are expected to show high thermal and chemical stability. Therefore, these catalysts can be easily separated out from the reaction mixture and re-activated for cycle use. Furthermore, we will use these catalysts in a continuous-flow reactor, which could open up a new avenue for catalyst industry.

Keywords: metal free catalyst,heterogeneous,recyclable,photocatalysis,diels alder reactions
Rapid pulse width modulated CO2 ejector for small-scale vapour-compression systems (ECO2-RAPJECT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-08-05
End date: 2021-08-04
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

Small-scale Refrigeration, Cooling&Heating (RC&H) sector plays a vital role in modern life promoting health, comfort and economic prosperity. On the other hand, it is also responsible for a considerable contribution to global warming. The urgent need for an eco-friendlier future has forced the European Union (EU) to implement stringent energy and environmental policies, affecting this sector significantly. These have led such a large and ever-growing industry to suffer for the lack of a long-term solution complying with safety and EU’s requirements. This project aims at filling the aforementioned technological gap by studying an innovative and future-proof small-scale vapour-compression RC&H unit relying on: (1) CO2, being a non-flammable, non-toxic and climate-friendly refrigerant, as the sole working fluid and (2) a two-phase ejector with a novel capacity control technique. The core of the work is to establish the experimental evidence and expertise regarding the innovative capacity control methodology for CO2 two-phase ejectors. At present, two-phase ejectors cannot readily be capacity controlled without penalizing ejector and system efficiency in small-scale RC&H units. As concrete value and impact, this project will lay robust foundations for a significantly more sustainable future and thus pave the way for remarkable enhancements for business and society concerning the RC&H sector. The fellow is a proficient researcher with a strong background in large-scale CO2 refrigeration systems using two-phase ejectors. The results and the experience that the applicant has obtained make him the ideal candidate for successfully achieving the project objectives. This work is a unique opportunity for the fellow to become an independent scientist, enhancing and developing new skills in a leading research field, such as the eco-friendly RC&H sector. These competences are highly valued in academia and industry in the context of the EU policies and the Paris climate agreement.

Keywords: air conditioner,chiller,condensing unit,eco friendly refrigeration and coolingandheating,efficiency improvement,expansion work recovery,experimental and numerical study,heat pump,r744,two phase ejector
Uncovering the Transatlantic History of Turkey Husbandry and Breeding using a Multi-Disciplinary Approach (TURKEY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

For 2000 years, turkeys (Meleagris gallopavo) have been kept and raised by indigenous cultures in North and Central America. In the late 15C, European travellers 'discovered' turkeys and quickly introduced them to Europe and beyond. Their popularity has only increased over time, and in both continents, turkeys are now the most commonly raised bird after chicken. Investigations into the emergence of turkey breeding are fundamental to understanding the evolving economic and symbolic relationships between humans and this iconic bird, as well as to provide historical challenges: first, the diversity of the specimens introduced in Europe (subspecies involved, geographic origin) is unknown; second, the diversity of morphologically similar birds raised in the same time (chicken, guinea fowl, peacock) hamper the recognition of early turkeys from America. This research project will pair the zooarchaeological and morphometrics expertise of the applicant, Aurélie Manin, with the biomolecular specialists in the BioArCh group at the University of York, UK, to document and explore turkey husbandry practices in Western Europe from 15C to 19C and its integration in pre-existing backyards. Using combined morphometric and biomolecular analyses this project will: 1) document the origins and intensity of turkey breeding in Europe; and 2) explore the changing socio-economic role of turkeys as they spread through modern Western Europe. Fundamentally, the results of this research will address both archaeological and food production issues by exploring the history of turkey husbandry and providing important data on the evolution of modern breeds, management practices and the resilience of modern poultry industry.

Keywords: domestication,meleagris gallopavo,zooarchaeology,columbian exchange,western europe,northern america
Innovating Hessian SMEs towards Europe (InnoHessen2Europe)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Germany,Germany,Germany,Germany
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 167120.0
EU funding (EUR): 167120.0
Participants: 5
Project status: CLOSED

With this proposal the coordinator of the EEN Hessen consortium, Hessen Trade & Invest GmbH (HTAI), participates as a sole partner in the Consultation of Enterprise Europe Network partners on the work programme for 2017-2018 Horizon 2020 specific activities. HTAI will implement the action „EEN Services Enhancing the Innovation Management Capacity of SMEs“.Thus EEN Hessen will contribute to the aims of the Europe 2020 strategy in terms of increasing the business performance of SMEs. Beneficiaries of the SME Instrument will be supported with Key Account Management (KAM). EEN Hessen will assess their gaps and challenges, identify a suitable coach, facilitate the interaction between the coach and the SME and respond to further needs by additional support measures. The overall aim is to enable those companies to conduct their innovation projects successfully and thus to contribute to their commercial growth. Other SMEs with significant innovation activities and a high potential for growth and internationalisation will be supported in the separate process of Enhancing Innovation Management Capacity (EIMC). EEN Hessen will identify suitable companies in Hessen and motivate them for the EIMC service, assess their gaps and needs, develop together an action plan and facilitate its implementation. With these activities, complemented by a wide range of further EEN services, HTAI strives to increase the competitiveness of Hessian SMEs and strengthen their ability to operate successfully in the European Single Market and outside. The action will be conducted by EEN Hessen innovation experts, all senior staff experienced in innovation management. They will use the „Innovation Health Check“ by Enterprise Ireland as a CEN/TS 16555-1 tool to assess the innovation management capacity of Hessian clients and to identify needs to be responded to. EEN Hessen will further follow the methodology provided by the EASME for EEN innovation services.

Keywords: innovation support,sme support,innovation management,sme instrument,internationalisation,een hessen
Information Encoding in Quantum Gravity and the Black Hole Information Paradox (HoloHair)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-10-01
End date: 2025-09-30
Duration (months): 60.0
Total project cost (EUR): 1497340.0
EU funding (EUR): 1497340.0
Participants: 1
Project status: SIGNED

LIGO’s detection of merging black holes was a spectacular confirmation of general relativity (GR), yet it remains an open question whether black holes obey the same rules of quantum mechanics (QM) as all other known objects in the universe. Black holes are objects in GR which are known to have a vast entropy, but when QM is applied they evaporate by emission of Hawking radiation which carries no information about their microstates - this is the black hole information loss paradox which has evaded a resolution for over 40 years. The holographic AdS/CFT duality has provided indirect evidence that black holes are quantum mechanical systems that do not destroy information but the arguments are limited in scope to highly charged and/or spinning black holes and do not explain the gravitational dynamics near the horizon. To resolve the information paradox we need a better understanding of the information encoding, storage and flow between the horizon and the far asymptotic region where Hawking radiation escapes to, and more generally of how information is encoded in quantum gravity in asymptotically flat Minkowski spacetime. Achieving this is the overarching goal of this proposal. The novel research I propose combines two emergent ideas which could provide a paradigm changing picture of how black holes encode information: One is based on a thorough understanding of subtle long-distance effects in asymptotically flat spacetimes which give rise to “soft hair” and a horizon memory for black holes. The other is based on a mechanism in string theory, the most promising quantum completion of Einstein's theory of GR, which gives rise to horizon-scale microstructure, known as “fuzzballs”. The ground-breaking nature of this proposal is to bridge these two different approaches to develop a powerful new programme for solving the information paradox.

Keywords: black holes,holography,string theory,asymptotic symmetries,conformal field theory
Three-dimensional dynamic views of proteomes as a novel readout for physiological and pathological alterations (Proteomes-in-3D)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Protein expression screens are routinely used to identify biological processes deregulated upon disease development or upon specific cellular perturbations. Generating molecular hypotheses from these ‘omic data remains challenging, however, and many molecular events that modulate protein function do not involve altered protein levels. With this project, I propose a new paradigm. I propose that by measuring altered structures of proteins on a global scale, we can capture altered functional states of proteins and proteomes. I propose that the new approach will support the generation of testable molecular hypotheses from global data and the development of new frameworks for the modelling of biological systems. Building on a unique mass spectrometric approach my lab developed, which captures protein structural changes on a proteome-wide scale, we will assess the performance of the global structural readout at analyzing complex phenotypes. We will apply it to a biomedical problem of interest to my lab: the functional and pathological implications of protein aggregates or superassemblies (SAs). Protein aggregates form not only during disease but also under physiological conditions. These structures regulate important normal processes and contribute to cellular architecture. Using the new structural approach, we will identify and characterize networks of novel functional SAs in E. coli, mouse, and human proteomes. We will assess how genomic variation, environment and age modulate protein structures and SA assembly and how SAs are linked to phenotypes. Last, we will translate our approach to a clinical setting and ask whether altered protein structures can serve as biomarkers of disease, specifically Parkinson’s disease and how SAs underlie Parkinson’s subtypes. We will collect the wealth of dynamic structural data generated through this project into an Atlas of Structural Proteome Dynamics and use the data to shed new light on features of the structural proteome.

Keywords: proteomics,structural proteomics,protein aggregation,metabolism,parkinson s disease,alpha synuclein,structural systems biology
Micro mEchanical Characterization of A ThErmoplastic Co-conSolidated / welded joinT for usE in aiRcraft fuSelages (MECATESTERS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,Netherlands
Call: Micro mechanical characteristics of a PEKK Co-consolidation / welded joint for use in thermoplastic fuselages (H2020-CS2-CFP08-2018-01, 2018)
Start date: 2019-04-01
End date: 2022-09-30
Duration (months): 42.0
Total project cost (EUR): 966355.0
EU funding (EUR): 836170.0
Participants: 2
Project status: SIGNED

The Large Passenger Aircraft (LPA) Platform 2 – Multifunctional Fuselage Demonstrator (MFFD) will employ new combinations of airframe structures, cabin/cargo, and system elements using advanced materials, notably HPTP composites. The MFFD is focused on achieving significant cost and weight reductions, coupled with high production rates. To bring these materials to market, there is a need to validate direct joining methods, which eschew traditional adhesive bonding in order to reduce cycle time and improve joint quality. The MECATESTERS project represents a key step in the progression of such technologies to widespread use in the aerospace sector. It will permit a greater level of understanding of the micro-mechanical behavior of the interfaces – an understanding which is currently limited: issues such as aging, healing, processing parameters, and durability need to be investigated in greater detail in order to develop a coherent approach. The MECATESTERS project will elucidate many aspects of thermoplastic joining using precision thermoplastic welding (PTW) methods. It will examine systematically the effects of surface condition, matrix aging, and bonding method on the reliability and performance of assemblies bonded using a variety of thermoplastic welding technologies.

Keywords: composites,thermoplastic,welding
INVENTIA SOLUTION DEVELOPMENT MARKET PENETRATION (INVENTIA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Italy
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2015, 2015)
Start date: 2015-12-01
End date: 2016-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Inventia is an innovative Company at the edge of the so called Video Customer Engagement Solution sector. Through Inventia SW, named "Connect", our Clients, B2C Retail and Service Companies, can insert Human Interaction inside their Digital Self Service oriented processes, be they implemented via e-commerce and mobile APP or performed through DIgital Kiosk/Self Services. We have launched our solution, implemented As-A-Service on major Cloud Infrastructures, in 2013, serving since then Client such as Banks, Telcos, Insurers, etc. Our solution has been welcomed by our Clients and their Customers, improving customer experience and creating a sound business case for deployment. We have invested over 1M€ in our Company so far. Born in Italy, we are extending our reach to other EU countries as well as to promising sectors such as e-Government and Healt Care.

Keywords: customer engagement solution,human interaction