Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mechanistic Integration of vascular aND endocrine pathways for Subtyping Hypertension: an Innovative network approach for Future generation research Training (MINDSHIFT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Italy,France,Netherlands,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 4124385.0
EU funding (EUR): 4124385.0
Participants: 6
Project status: SIGNED

Hypertension is the key determinant of cardiovascular disease and the No.1 ‘silent killer’ of humans worldwide. Despite progress in understanding the causes of hypertension and improvements in clinical management, >85 million people in Europe suffer from cardiovascular disease, costing the EU €210 billion/year. Currently, there is a crucial gap in understanding the dynamic interactions between vascular and endocrine pathways in hypertension. Such knowledge would facilitate redefinition of hypertension subtypes to improve current prevention and treatment. MINDSHIFT will offer a top-level interdisciplinary research programme to bridge this gap, using an integrative framework approach fed by new data and insights from cutting-edge experimental and clinical studies. To enable this advance, MINDSHIFT will implement and run an innovative EJD-programme, combining first-class scientific research with in-depth professional and transferable competence-skills trainings. ESRs will develop the integrative and entrepreneurial capacities that hypertension research demands by nature. Above and beyond, the programme will challenge the ESRs to build their capacity for self-directed learning, career development and personal-professional leadership. The highly capable academic and non-academic partners in MINDSHIFT have co-designed an extraordinary high-quality programme of research projects and network-wide training elements, to achieve the required and sustainable impacts on the ESR careers, scientific results and ITN-wide learning and innovation. Based on the excellent synergies and shared commitments, the MINDSHIFT consortium seeks to establish a European School for Hypertension Research, to propel future health science and industry towards more effective prevention of and cure for this silent killer.

Keywords: high blood pressure,vascular disease,endocrinology,obesity,bioinformatics,self directed learning,health technology,biomarkers,competence,organisational learning,leadership
Monte-Carlo Determination of Causation in Turbulence (CausT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Spain
Call: ERC ADVANCED GRANT (ERC-2020-ADG, 2020)
Start date: 2021-08-01
End date: 2026-07-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Simulations have driven many recent scientific advances. In the case of the physics of fluid turbulence, they have involved some of the most expensive computations at any time, but faster computers now permit meaningful simulations to run in minutes in a modest machine. This proposal centres on exploring the role of simulations in this limit of ‘zero’ computing cost, and on the analysis of the resulting data. What ‘free’ simulations allow is ‘Monte-Carlo’ research, in which ideas are ‘randomly’ tested and only evaluated afterwards, in the hope that some of them be fruitful. Their main advantage is to alleviate ‘paradigm lock’, in which radically new ideas are unlikely to get tested and knowledge gets stuck in a local optimum. But ensembles of cheap simulations also provide causal information about what the effect of a particular ‘random’ initial condition is. The main result in turbulence is expected to be the identification of novel flow structures, with definitions grounded in the underlying physics. Up to now, structures have mostly been described in terms of properties assumed to be important (e.g. intensity), with their effect on the flow being tested a-posteriori, but Monte-Carlo search allows us to reverse the process, identifying structures from their effects. In particular, we will search for flow configurations that are ‘causally most sensitive’ to perturbations, in the sense that the perturbations are most effective when applied to them. Both the probing perturbations and the receptive flow states constitute ‘causes’. The implied definition of causality only applies over times of the order of a turnover, and is connected with control: changing the cause modifies the effect, with obvious applications. The flows examined will mainly be wall-bounded ones, including effects such as rotation and rheology, but we will also examine the general inverse energy and momentum cascades towards larger scales. Some preliminary experiments are described.

Keywords: turbulence,simulations,monte carlo searches
Unravelling Fragile 1D Quantum States of Matter Through Ultra-sensitive Imaging (See-1D-Qmatter)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-01-01
End date: 2022-06-30
Duration (months): 78.0
Total project cost (EUR): 2475000.0
EU funding (EUR): 2475000.0
Participants: 1
Project status: CLOSED

In condensed matter physics there are several iconic predictions that have evaded experimental discovery for many decades. Well-known examples include the proposed fractionally-charged quasiparticles in one-dimension, the theorized quantum crystal of electrons, and the elusive Kondo cloud. These sought-after many-body states all share two key aspects underscoring why they are so hard to discover: They each involve a fragile quantum state of matter that is destroyed easily by disorder or elevated temperatures, and in each case the distinguishing fingerprint is encoded in their real-space structure, which is often difficult to probe directly. The discovery of such phases therefore requires two challenging experimental components: A superb material system in which these phases can be generated, and a novel real-space probe that can image their spatial structure, yet is minimally invasive as not to destroy them. Recently, we have developed a radically new approach for creating the state-of-the-art in both material systems and scanning probes, based on carbon nanotube devices of unprecedented complexity and cleanliness. With these components in place, we are poised to make the next quantum leap in technology by building a conceptually new experimental platform in which fragile quantum states of matter can be realized and studied microscopically: We will use a nanotube single-electron-transistor as a high-resolution, ultrasensitive scanning charge detector to non-invasively image an exotic quantum state within a second pristine nanotube. With this new platform we will thus be able to address several foundational questions in condensed matter physics (including those mentioned above) and unravel their underlying physics.

Keywords: scanning probe,nanotube,fractional charge,wigner crystal,one dimension,luttinger liquid,coulomb drag,exciton condensation,kondo effect,single electron transistor,quantum dots
Strategic and Targeted Support for Europe-Ukraine Collaboration in Aviation Research (AERO-UA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Coordination and support actions
Countries involved: Ukraine,Germany,Poland,United Kingdom,Luxembourg
Call: Identification of gaps, barriers and needs in the aviation research (H2020-MG-2016-SingleStage-INEA, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 1000000.0
EU funding (EUR): 1000000.0
Participants: 9
Project status: CLOSED

The overall aim of the AERO-UA project is to stimulate aviation research collaboration between the EU and Ukraine through strategic and targeted support. AERO-UA is focused solely on Ukraine, because the country has a huge aerospace potential but a low level of aviation research collaboration with the EU. Ukraine’s aerospace sector spans the full spectrum of systems and components development and production with OEMs, Tier 1 and 2 suppliers, aeroengine manufacturers, control systems manufacturers, R&D institutions, aeronautic universities, and SMEs. This is also reflected in the sector's important contributor to the country’s economy (e.g. aircraft production of €1,9 billion in 2011). Ukrainian aerospace organisations possess unique know-how that can help Europe address the challenges identified in the ACARE SRIA / Flightpath 2050 Report. Furthermore, following the signing of the Agreement for the Association of Ukraine to Horizon 2020 in March 2015, Ukrainian organisations are eligible to participate in Clean Sky 2 and H2020 Transport on the same funding terms as those from EU member states. Equally, genuine commercial opportunities exist for European aviation organisations to help modernise Ukraine’s aerospace sector. The AERO-UA project will achieve its overall aim via four high-level objectives: 1. Identifying the barriers to increased EU-UA aviation research collaboration; 2. Providing strategic support to EU-UA aviation research collaboration; 3. Supporting EU-UA aviation research knowledge transfer pilot projects; and 4. Organising awareness-raising and networking between EU-UA stakeholders. The AERO-UA consortium is comprised of key EU and UA aviation organisations that will implement WPs closely mapped to the high-level objectives. The consortium will be supported by an Advisory Board involving Airbus, DLR, Min. Education and Science of Ukraine, Ukrainian State Air Traffic Services Enterprise and retired Director of EADS Jean-Pierre Barthélemy.

Keywords: ukraine,aviation research,flightpath 2050
N-Myc and Aurora A: From Protein Stability to Chromosome Topology N-Myc and Aurora A: From Protein Stability to Chromosome Topology Myc and Aurora A: From Protein Stability to Chromosome Topology (AUROMYC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Germany,United Kingdom,United Kingdom
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-08-01
End date: 2021-04-30
Duration (months): 69.0
Total project cost (EUR): 2455180.0
EU funding (EUR): 1891017.5
Participants: 3
Project status: CLOSED

There is an intense interest in the function of human Myc proteins that stems from their pervasive role in the genesis of human tumors. A large body of evidence has established that expression levels of one of three closely related Myc proteins are enhanced in the majority of all human tumors and that multiple tumor entities depend on elevated Myc function, arguing that targeting Myc will have significant therapeutic efficacy. This hope awaits clinical confirmation, since the strategies that are currently under investigation to target Myc function or expression have yet to enter the clinic. Myc proteins are global regulators of transcription, but their mechanism of action is poorly understood. Myc proteins are highly unstable in normal cells and rapidly turned over by the ubiquitin/proteasome system. In contrast, they are stabilized in tumor cells. Work by us and by others has shown that stabilization of Myc is required for tumorigenesis and has identified strategies to destabilize Myc for tumor therapy. This work has also led to the surprising observation that the N-Myc protein, which drives neuroendocrine tumorigenesis, is stabilized by association with the Aurora-A kinase and that clinically available Aurora-A inhibitors can dissociate the complex and destabilize N-Myc. Aurora-A has not previously been implicated in transcription, prompting us to use protein crystallography, proteomics and shRNA screening to understand its interaction with N-Myc. We have now identified a novel protein complex of N-Myc and Aurora-A that provides an unexpected and potentially groundbreaking insight into Myc function. We have also solved the crystal structure of the N-Myc/Aurora-A complex. Collectively, both findings open new strategies to target Myc function for tumor therapy.

Keywords: tumor biology,cancer,oncogenes,neuroendocrine tumors
Biomimicking nanostructured materials via intra(inter)molecular folding of sequence-controlled polymers (BINAMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United States,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-20
End date: 2019-07-19
Duration (months): 30.0
Total project cost (EUR): 211825.2
EU funding (EUR): 211825.2
Participants: 2
Project status: CLOSED

Nature employs various polymerization processes (e.g. DNA replication, transcription and translation of proteins) in order to synthesize biopolymers such as DNA and proteins with controlled sequences and configurations. Such remarkable and complicated structures can fold into precise nanostructures via intramolecular and intermolecular interactions and thus replicating these domains via synthetic polymers has recently attracted considerable interest. The goal of BINAMA is to synthesize biomimicking nanostructure materials via intramolecular folding of sequence-controlled polymers in the presence of a “real” catalyst/chaperone, thus mimicking the intracellular environment. For the first part of the project, the sequence of functional monomers will be controlled utilizing controlled living radical polymerization methods. Subsequently, the incorporation of these monomers will induce hydrogen bonding, hydrophobic/hydrophobic, pi-pi, charge and disulphide interactions typically employed by proteins in order to facilitate the controlled folding of the polymer chains, adopting natural motifs and patterns. The ability to mimic these perfectly defined sequence-controlled polymers (e.g. DNA and proteins) via synthetic polymer chemistry will pave the way for synthetic bioanalogues and could also enhance their functions and properties.

Keywords: sequence controlled polymers,biomimicking materials,intra and intermolecular interactions,atrp,raft
Oblivious identitY Management for Private and User-friendly Services (OLYMPUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Ensure privacy and freedom, including in the Internet and enhance the societal, legal and ethical understanding of all areas of security, risk and management
Action type: Innovation actions
Partnership: Cybersecurity PPP (cPPP)
Countries involved: Spain,Spain,Switzerland,Sweden,Portugal,Denmark
Call: Cybersecurity PPP: Privacy, Data Protection, Digital Identities (H2020-DS-SC7-2017, 2017)
Start date: 2018-09-01
End date: 2021-11-30
Duration (months): 39.0
Total project cost (EUR): 3147837.5
EU funding (EUR): 2564480.01
Participants: 6
Project status: CLOSED

At first sight, privacy and strong identity seem inherently at odds. Indeed, if users are strongly identified during a transaction, then privacy is non-existent. Nevertheless, there exist mechanisms that can reconcile privacy and strong identity, either by trusting an online identity provider (IDP), or by using cryptographic mechanisms such as anonymous credentials. The former approach, made popular by technologies such as SAML, OpenID Connect, and Facebook Connect, has the disadvantage that the IDP forms a single point of failure in terms of privacy and security, because it can impersonate and track its users online. The latter approach has the disadvantage that users have to rely on trusted hardware such as smartcards to protect credentials from compromise and from illegitimate sharing. OLYMPUS will take a radically new approach offering the seamless user experience of online IDPs, but without their drawbacks. Namely, OLYMPUS will pioneer the concept of distributed oblivious identity management, where the role of the IDP is split over multiple authorities, so that no single authority can track or impersonate their users. By exploiting advanced techniques based on threshold cryptography, the OLYMPUS framework will let users maintain unlinkable identities with different service providers while using standard devices and a single password or biometric. By leveraging existing eID solutions to create a strong link to physical identities, and by integrating into existing frameworks to ease adoption by service providers, OLYMPUS will establish a secure and interoperable European identity management framework. Its practical feasibility and relevance will be demonstrated in two pilots. The first combines the framework with soft identity proofs to build a mobile driver license application that can be used for offline purchases of restricted goods. The second use case will leverage pseudonymous identification in the financial world to simplify online credit application
Feeding, Educating, Dieting: a Transnational Approach to Nutrition Discourses in Children’s Narratives (Britain and Italy, 1850-1900) (FED)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-09-29
Duration (months): 24.0
Total project cost (EUR): 183473.28
EU funding (EUR): 183473.28
Participants: 1
Project status: CLOSED

‘Feeding, Educating, Dieting’ (FED) is a comparative qualitative analysis of mal/nutrition narratives, i.e. images of characters eating/fasting, in 1850-1900 British and Italian children's literature. Adopting a new historicist and discourse theory approach to comparative reading of British and Italian narratives, the project examines nineteenth-century trans/national discourses about child mal/nutrition and assesses children’s literature’s role in circulating these discourses. Child mal/nutrition is an increasingly concerning health issue in Europe, which prompted the EU to draw the Action Plan on Childhood Obesity 2014-2020. Concern for this transnational issue can be traced back to the late-Nineteenth century, a definitional moment for national identities. Countries with different histories and food cultures addressed the idea of growing a healthy nation looking at the raising middle-class values in a process that engaged food, health, and literature. Using England and Italy as a case study, FED examines a selection of 1850-1900 Italian and British narratives to develop a framework to analyse the circulation of nineteenth-century child mal/nutrition discourses through children's fiction, highlighting their transnational nature. This framework will outline the core features of characters eating/starving in the selected narratives and unpack how these conveyed dominant discourses about gender roles, social power, and the healthy body/mind. As an expert in the application of new historicism and discourse theory to Victorian fiction, in FED I apply my main theoretical framework to the traditional comparative approach used in children’s literature studies to increase our understanding of how literature and food culture merge in national identity discourses. On a larger scale, FED promotes discussion on how literary studies can address current European issues such as child mal/nutrition and promotes international collaborative research on the topic.

Keywords: children s literature,victorian studies,food studies,transnational literary studies
Supporting and Implementing Plans for Gender Equality in Academia and Research (SPEAR)

Framework: Horizon 2020 — Science with and for Society
Programme: Promote gender equality in particular by supporting structural change in the organisation of research institutions and in the content and design of research activities
Action type: Coordination and support actions
Countries involved: Germany,Austria,Bulgaria,Bulgaria,Bulgaria,Croatia,Lithuania,Lithuania,Sweden,Hungary,Portugal,Denmark
Call: Supporting research organisations to implement gender equality plans (H2020-SwafS-2018-1, 2018)
Start date: 2019-01-01
End date: 2023-04-30
Duration (months): 52.0
Total project cost (EUR): 2997008.75
EU funding (EUR): 2997008.75
Participants: 15
Project status: CLOSED

SPEAR will initiate institutional change in nine European research performing organizations (RPOs) by implementing gender equality plans. Despite numerous EU-wide projects aimed at improving gender equality (GE) in academia, challenges persist, and GE practitioners and change agents experience fatigue and lack of support structures. SPEAR offers supportive structures through its interconnected Community of Learning (CoL) and Community of Practice (CoP). CoL will provide learning platforms while CoP provides an arena for experience exchanges. Both are crucial to successful and sustainable implementation of gender equality plans (GEPs), a key instrument to improving GE. SPEAR’s central objective is to support and implement GEPs, based on a step-by-step guide to GEP implementation devised by the European Institute for Gender Equality, through following a methodological path committed to creative, open, mitigating, processual, accountable, SMART and sustainable changes (SPEAR’s COMPASS). Integral to SPEAR’s project design is an enhanced impartial evaluation scheme to boost the feedback and learning of participants throughout the project. SPEAR employs strategic dissemination to boost its central sustainability commitment during and after SPEAR. SPEAR’s consortium numbers eleven partners, three of which have some experience with GE work while six have little or no experience. The first three will coordinate sessions during CoL and provide crucial support and best-practice guidance during structured interactions in CoP. Two task partners handle evaluation and dissemination. An advisory group representing key GE-stakeholders is affiliated. SPEAR aims to foster sustainability in GE-practices in academia through a range of measures and outcomes, including ties to other EU-based GE projects, network and community building within and beyond SPEAR, and formulation of practicable policy recommendations.

Keywords: equality,academia,rpos,implementation of gender equality plans,supportive structures,learning,practice,processes,communities,sustainability,evaluation,practitioners,institutional change