Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Measurement of charm matter-antimatter asymmetries (CharmingAntimatter)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-08-01
End date: 2020-01-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Flavour physics, and the study of antimatter in particular, is one of the most exciting fields at the frontier of fundamental physics research. It is driven by the question of what happened to the antimatter after the Big Bang and is a recognized long-term priority as part of the CERN European strategy for particle physics. Nature provides particles that contain both matter and antimatter quarks as ideal laboratories for the discovery of matter-antimatter asymmetries (CP violation). This proposal will focus on the least explored of these particles, charm mesons; CP violation discoveries in strange and beauty mesons have already led to Nobel Prizes. The centrepiece of the action is a measurement based on data from the LHCb experiment, the world's leading player in flavour physics. The analysis will use one of the most complex techniques for the most sensitive decay mode of charm mesons. The determination of the decay-time dependence of the phase-space structure of this decay gives access to fundamental parameters of nature governing both matter-antimatter oscillations and CP violation. This multi-dimensional analysis involving millions of charm particle decays is computationally extremely challenging. This will be overcome by the development and exploitation of novel techniques of parallel programming on graphical processing units. For the needs of the analysis, the project includes a required improvement of the Geant4 Monte Carlo generator software to allow more efficient and more accurate simulation of matter-antimatter differences. The proposal also includes studies to find the optimal method for statistical combination of charm oscillation and CP violation measurements to combine the results of all LHCb measurements involving different decay modes and methods.

Keywords: cp violation,flavour physics,lhcb
Modeling and Analysis of Random Spatial Systems for 5G Networks (MARSS-5G)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-07
End date: 2017-09-06
Duration (months): 24.0
Total project cost (EUR): 173857.2
EU funding (EUR): 173857.2
Participants: 1
Project status: CLOSED

The United Nations International Telecommunications Union (ITU) has recently reported that the number of mobile users is expected to surpass the world population. In fact, it is expected that by 2020 mobile users will exceed an astonishing 9 Billion subscribers. With this unprecedented market penetration and growth, many communication engineering challenges are anticipated. In particular, next generation 5G wireless systems must be designed using sophisticated and innovative strategies and techniques. While 5G applications are expected to be diverse, the network architectures and devices need to ensure and deliver reliable, pervasive, and high-speed interconnection for various data-intensive applications (e.g., interactive multimedia streaming). These requirements must be accomplished while necessitating limited resources for a continuously expanding consumer demographics. Thus, deploying such complex networks is a formidable engineering feat that requires novel ways of modeling, evaluating, and designing extremely dense radio systems. This project aims, through the study of spatial geometry of randomly deployed mobile units, to develop several analytical tools to model, design, and analyze complex 5G networks, and validate them through experimental datasets. Ultimately, our broad goal is to conceptualize an engineering research idea, and then transitioning it into innovative applications that can be replicated for real-world cellular networks operated by established service providers and mobile manufacturers.

Keywords: 5g networks,spatial modeling,stochastic geometry
An unrivalled medical device for severe cancer treatment complications:exact & easy red-LED photobiomodulation for mucositis and dermatitis (CareMin650)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-05-01
End date: 2022-04-30
Duration (months): 36.0
Total project cost (EUR): 3419936.25
EU funding (EUR): 2393955.38
Participants: 2
Project status: CLOSED

Today the healthcare system is under great pressure due to the increasing incidence of cancer, which is also affected by ageing of the population. However, all efforts in the medical industry have concentrated on early diagnosis and treatment of cancer, so that this is becoming a chronic disease. The surfacing challenge from now on will be improving the quality of life of cancer patients. Mucositis and radiodermatitis are the most common and most debilitating side effects suffered by cancer patients but, so far, there is no approved preventive or curative treatment. In the last years, photobiomodulation has gained traction but the technology is still expensive, complex and inaccurate. CareMin650 is an innovative LED-based phototherapy device that will make photobiomodulation for the treatment of these conditions accurate, easy and inexpensive, thanks to its flexible fabric made of woven optic fibre. Neomedlight is proprietary of this core technology and knows a previous market success across Europe applying it to the niche market of jaundice treatment with Bilicocoon®. We now have validated the reliability of CareMin650 to deliver a fast, comfortable and painless treatment for patients; these are the added values to our central value proposition: a system for preventive and curative delivery of an accurate dose of red light. Moreover, this is a cost-effective solution to increase the quality of life and the survival of cancer patients: In the EU alone, CareMin650 will contribute to reduce the 200,000 cancer deaths and the €27.9 billion economic burden associated to mucositis and radiodermatitis. We have a huge untapped market ahead and now want to finalise CareMin650 development and achieve market preparedness. The SME Phase 2 project will allow NeoMedLight to put on the market a medical device that will boost the growth of the company, with an expected €20.8 million cumulative profit, a ROI of 5.08 and from 8 to 20 new job positions by 2025.

Keywords: oral mucositis,dermatitis,radiotherapy,chemotherapy,leukaemia,head and neck cancers,breast cancer,photo biomodulation,led technology,red light,portable device
leArning and robuSt deciSIon SupporT systems for agile mANufacTuring environments (ASSISTANT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Ireland,Greece,Belgium,Belgium,Sweden,France,France,Luxembourg
Call: Artificial intelligence for manufacturing (H2020-ICT-2020-1, 2020)
Start date: 2020-11-01
End date: 2023-10-31
Duration (months): 36.0
Total project cost (EUR): 5997106.25
EU funding (EUR): 5997106.25
Participants: 13
Project status: SIGNED

With a multidisciplinary consortium combining key skills in AI, manufacturing, edge computing and robotics, ASSISTANT aims to create intelligent digital twins through the joint use of machine learning (ML), optimization, simulation and domain models. The resulting tools permit to design and operate complex collaborative and reconfigurable production systems based on data collected from various sources such as IoT devices. ASSISTANT targets a significant increase in flexibility and reactivity, products/processes quality, and in robustness of manufacturing systems, by integrating human and machine intelligence in a sustainable learning relationship. ASSISTANT provides decision makers with generative design based software for all manufacturing decisions. Rather than writing ad hoc code for each manufacturing sector, it provides a set of intelligent digital twins that self adapt to the manufacturing environment. It promote a methodology that enhances generative design with learning aspects of AI thanks to the data available in manufacturing. ASSISTANT aims to synthesize predictive/prescriptive models adjusted to the shop floor for each decision levels. Digital twins will be used as oracles by ML in order to converge towards models in phase with reality. This means that rather than writing specific code to cover a restricted set of goals/scenarios/hypotheses for a manufacturing system and a decision level, ASSISTANT will aim at learning models that can be used by standard optimization libraries. In this context, ML is used to predict parameter values, characterize parameters uncertainty, and acquire physical constraints. ASSISTANT will experiment this methodology on a significant panel of use cases selected for their relevance in the current context of the digital transformation of production in major manufacturing sectors undergoing rapid transformations like the energy, the industrial equipment, and automotive sectors which already make extensive use of digital twins.
Clinical validation of the CD32b biomarker on the European market (BI-MARK)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Sweden
Call: Clinical research for the validation of biomarkers and/or diagnostic medical devices (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The overall objective of the proposed project is the clinical validation of a novel biomarker for B-cell malignancies. The presently most widely used anti-CD20 antibody treatment rituximab has considerably improved treatment options for patients with B-cell malignancies. However, effectiveness is limited by resistance to rituximab and reduced response on repeated treatments. Data indicates that tumor expression of CD32b is directly involved in the development of resistance to rituximab. CD32b has the potential to be used as predictive biomarker for critical clinical decisions for rituximab and related treatments, and will impact payers and patients. In addition, our company is developing a novel treatment – BI-1206 that specifically targets CD32b and significantly improves antitumor effects of rituximab alone. As such, the CD32b biomarker assay has the additional potential to become a companion diagnostic for BI-1206 and other future B-cell malignancy treatments. Our company and the affiliated research team have developed a flow cytometry assay for the detection of the CD32b receptor on tumor cells. The assay has been partially validated in a clinically relevant setting to demonstrate CD32b as a predicative biomarker of therapy response. To achieve market uptake of our technology, we aim to conduct a number of studies together with selected clinical partners in Europe. The objectives of the feasibility study are to find and contact researchers/clinicians for conducting retrospective and/or prospective studies, as well as to refine the business model for the commercialization of the biomarker assay. The intended users of our product are clinicians and therapy developers that focus on B-cell malignancies. By clinically validating a biomarker assay for B-cell malignancies and especially CLL, our company addresses an unmet European and global need for improved treatments for CLL, and B-cell malignancies in general.

Keywords: b cell malignancy,non hodgkin lymphoma,rituximab
Solar magnetic field and its influence on solar variability and activity (SOLMAG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2021-09-30
Duration (months): 60.0
Total project cost (EUR): 2418750.0
EU funding (EUR): 2418750.0
Participants: 1
Project status: CLOSED

For life on Earth, the Sun is the most important astrophysical object in the universe. For astrophysicists, the atmosphere of the Sun presents an intriguing, complex and extremely varied environment generated by continuous dynamic, small-scale interactions between plasma and intricately structured magnetic fields. The purpose of this proposal is to elucidate the physics underlying the structure and dynamics of the solar magnetic field that is responsible for the Sun’s varied activity and its variability. This goal is to be achieved by following an integral approach combining new observational facilities, novel instruments developed in the group of the PI, the next generation of inversion techniques for data analysis and state-of-the-art magnetohydrodynamic simulations. This wide range of expertise present in the group of the PI is unique and well suited to such an approach. The research proposed here will provide measurements of the Sun’s magnetic field at high spatial and temporal resolution at unprecedented sensitivity to Zeeman splitting and to magnetic flux. Also, the use of a novel polarimetric hyperspectral imager, combined with the next generation of inversion techniques will allow following the 3D structure of the magnetic field and of other physical parameters in time through a sequence of snapshots. This will enable following the build-up of magnetic tension and of waves following the field lines and will set important constraints on the heating mechanism of the solar chromosphere and corona. The proposed work, in particular the comparison of measurements with simulations, will also set constraints on the presence and properties of a small-scale turbulent dynamo as well as other fundamental physical processes taking place in the solar atmosphere. The techniques introduced here will enable reliable and robust measurements of chromospheric magnetic fields, shedding new light on this enigmatic but centrally important layer of the solar atmosphere.

Keywords: solar magnetic field,solar variability,solar atmosphere
Photo-Fenton degradation of Persistent Organic Pollutants present in Real Contaminated Waters using Solar pilot plant Reactors (SPFPs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-12-01
End date: 2023-03-22
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

In 2009, Lindane was included in the Stockholm Convention on Persistent Organic Pollutants (POPs) to achieve the global elimination of these substances. This international treaty mandates an irreversible destruction of POPs into non-POPs. Consequently, development of cost-effective, safe and environmentally technologies for the destruction of POPs is necessary. Although the Advanced Oxidation Processes (AOPs) are efficient in the treatment of this pollutants, many have the disadvantage of their high cost. A very useful alternative from the economic and environmental point of view is the use of solar energy integrated to these processes. This is Solar photo-Fenton Process (SPFPs). A detailed study associated with the photo-Fenton degradation of POPs (Lindane) present in real contaminated waters using a pilot plant Solar Reactor (SR) is proposed. This development includes an experimental work and rigorous mathematical modelling of photochemical reactors (laboratory and pilot plant scale), considering the fundamentals of chemical reactions (reaction mechanisms) and transport phenomena (mass and energy). The contaminated waters will be obtained at the Bailin landfill Sabiñánigo (Spain). The propose project addresses an environmental issue, highly relevant for current EU policies, included in UN Sustainable Development Goals, point 6 “Clean Water and Sanitation”. The innovative non-concentrate SR proposed aims to provide an economical/efficient alternative solution to this problem. This technology development would be used for many industries or communes that require an efficient treatment of their effluents. Based on the SR proposed, and considering the results obtained, the patent of these unit will be evaluated. The proposed realistic/highly ambitious work plan will be consistent with the extension of the call (24 mons.) The results obtained will be widely disseminated, not only in the scientific, but also in the academic and in the social.

Keywords: advanced oxidation process,persistent organic pollutants,photo fenton reaction,solar reactors,technical hexachlorocyclohexane,lindane
A genomics and systems biology approach to explore the molecular signature and functional consequences of long-term, structured fasting in humans (FastBio)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Greece
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-06-01
End date: 2025-03-31
Duration (months): 94.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Dietary intake has an enormous impact on aspects of human health, yet scientific consensus about how what we eat affects our biology remains elusive. To address the complex biological impact of diet, I propose to apply an unconventional, ‘humans-as-model-organisms’ approach to compare the molecular and functional effects of a highly structured dietary regime, specified by the Eastern Orthodox Christian Church (EOCC), to the unstructured diet followed by the general population. Individuals who follow the EOCC regime abstain from meat, dairy products and eggs for 180-200 days annually, in a temporally-structured manner initiated in childhood. I aim to explore the biological signatures of structured vs. unstructured diet by addressing three objectives. First I will investigate the effects of the two regimes, and of genetic variation, on higher-level phenotypes including anthropometric, physiological and biomarker traits. Second, I will carry out a comprehensive set of omics assays (metabolomics, transcriptomics, epigenomics and investigation of the gut microbiome), will associate omics phenotypes with genetic variation, and will integrate data across biological levels to uncover complex molecular signatures. Third, I will interrogate the functional consequences of dietary regimes at the cellular level through primary cell culture. Acute and long-term effects of dietary intake will be explored for all objectives through a two timepoint sampling strategy. This proposal therefore comprises a unique opportunity to study a specific perturbation (EOCC structured diet) introduced to a steady-state system (unstructured diet followed by the general population) in a ground-breaking human systems biology type of study. This approach brings together expertise from genomics, computational biology, statistics, medicine and epidemiology. It will lead to novel insights regarding the potent signalling nature of nutrients and is likely to yield results of high translational value.
ConcEpt validatioN sTudy foR fusElage wake-filLIng propulsioN intEgration (CENTRELINE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Poland,Sweden,France,Netherlands,United Kingdom
Call: Breakthrough innovation (H2020-MG-2016-Two-Stages, 2016)
Start date: 2017-06-01
End date: 2020-11-30
Duration (months): 42.0
Total project cost (EUR): 3680520.78
EU funding (EUR): 3680519.7800000003
Participants: 12
Project status: CLOSED

The CENTRELINE project aims at maximising the benefits of aft-fuselage wake-filling under realistic systems design and operating conditions. The concept realises fuselage wake-filling through a single propulsive device installed at the fuselage aft-end with the purpose to entrain and re-energise the fuselage boundary layer flow, the so-called Propulsive Fuselage Concept (PFC). The aft-fuselage propulsor is driven turbo-electrically with power supplied through generator off-takes from advanced geared turbofan engines in under-wing installation. CENTRELINE will perform the proof of concept and initial experimental validation for a highly promising propulsion-airframe integration approach in order to mature this technology from currently TRL 1-2 to TRL 3-4. Advanced pre-design methods based on high-fidelity numerical simulation and integrated multidisciplinary design optimisation techniques will be adopted in order to produce best and balanced design solutions for the concept. The technological key features will be initially validated through physical experiments including scale-model wind tunnel testing for the overall configuration as well as specialised aerodynamic rig testing of the boundary layer ingesting aft-fuselage propulsor. The proposed research and innovation actions represent the immediate exploitation of results of the highly successful FP7 L-0 project “DisPURSAL” (GA no. 323013). The optimised system technology concept will be eco-environmentally benchmarked against an advanced conventional reference aircraft equipped with aerodynamic, structural, power plant and systems technologies suitable for a potential Entry Into Service (EIS) year 2035, referred to as "R2035". The objective CO2 reductions of the concept at integrated vehicular level are -11% against the R2035 (which means –40% CO2 versus the Y2000 SRIA reference). A detailed technology roadmap will be developed, indicating how to transfer these improvements to TRL 6 in 2030.

Keywords: propulsive fuselage,wake filling,boundary layer ingestion,aero structural integration,validation,wind tunnel,fan rig test,turbo electric,fuselage fan,electric drive,multi disciplinary design