Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Chromatin dynamics during DNA replication (NChIP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-06-01
End date: 2020-05-31
Duration (months): 60.0
Total project cost (EUR): 1984677.0
EU funding (EUR): 1984677.0
Participants: 1
Project status: CLOSED

Chromatin assembly is a fundamental cellular process necessary for the maintenance of genome integrity and transcriptional programs. Understanding the effect of DNA replication on histone protein dynamics is also a prerequisite for understanding the role of chromatin in epigenetic inheritance. Epigenetic phenomena are thought to influence cellular differentiation and cancer formation, as well as the impact of environmental factors on early development and later predispositions to disease. While epigenetic inheritance of chromatin components is, in theory, accepted as the driver of such phenomena, chromatin state inheritance per se has only been demonstrated for a few specific cases. Not much is known about histone “inheritance” beyond the facts that bulk maternal histones distribute equally among the daughter strands and are diluted two-fold after replication with newly synthesized “unmarked” histones, and that the majority of H3/H4 tetramers do not split before reassembly. We have shown previously that maternal nucleosomes stay on average within 400bp of their original binding site, implying that any potentially heritable chromatin encoded information, has to be inherited in ~1kb blocs, as smaller nucleosome domains would rapidly be diluted by new nucleosomes. I propose to develop high throughput systems for directly measuring movements of histones and chromatin regulators during genomic replication in S.cerevisiae to determine, how chromatin states survive the perturbations associated with replication. We will determine locus specific differences in the spread of maternal nucleosomes after replication, the effects of leading and lagging strand replication on nucleosome positioning and maternal nucleosome distribution, the renewal dynamics of posttranslational histone marks and chromatin binding proteins, and the kinetics of chromatin footprint re-establishment and gene (re)activation.

Keywords: chromatin,dna replication,cell cycle
WISE – Wide Instantaneous Support Equipment (WISE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: France
Call: Small business innovation research for Transport (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In the aviation industry, the downtime of aircrafts due to maintenance operations, also called Aircraft On Ground (AOG), represents a huge economic loss for airline companies. Each 24 hours of AOG can cost up to 100 000$ to the company . While the repair of electronic circuits often takes only a few minutes, repairing a part of an aircraft’s structure can range from a couple of days to several weeks. The WISE (Wide Instantaneous Support Equipment) project aims at accelerating and improving structural repairs on aircrafts. In the current market organisation, structural repairs require onsite specialized expertise. As experts are not available in every airport, they often have to be flown on site and this creates costly delays. Instead of physically moving the experts, WISE will bring expert assistance to the onsite teams through an advanced augmented reality communication system. Any maintenance site will then be able to benefit from the cumulated expertise of SUNAERO, which provides better results than any individual expert and avoids the added inconvenience of delaying the repair. Air flight security will be improved and costs reduced. The WISE project stems from repeated requests from customers, challenging us to devise a device capable of bringing world-class expertise to their onsite general maintenance teams. As the financial and technical benefits of such a solution are quite obvious, the goal of this feasibility study is to prove that such a feat is achievable.

Keywords: aviation,maintenance repair overhaul mro,structural defaults
Industrial and commercial SCALE-up of Bio-on technology for the production of PHA polymers from sugar industries waste, co- and by-products (SCALEPHA)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The objective of the SCALEPHA Project is to contribute to the protection and sustainable management of natural resources and ecosystems through a sustainable supply and use of raw materials in the industrial production of 100% biodegradable bio-plastic, in order to meet the needs of a growing global population within the sustainable limits of the planet's natural resources and eco-systems. SCALEPHA activities will contribute to increasing European competitiveness, raw materials security and improving well-being, whilst assuring environmental integrity, resilience through an innovative integrated technology: Polyhydroxyalkanoate (PHAs). European Factories of the Future will have to be SMART (high performance, reconfigurable, adaptive and evolving factories based on new technologies) and GREEN (reduced ecological footprint through a more efficient use, at factory level, of material and energy resources): SCALEPHA project will demonstrate that Biotechnologies, such PHAs production, are the strategic technologies needed to keep the European Manufacturing leading edge. Side Objectives: - penetrate significantly the existing bioplastic market through PHAs (in particular Biomedical, Food Packaging and Design sectors); - diffusion and uptake of PHA innovation on a broad scale, maximising its economic and environmental benefits; - create or enlarge new markets for related PHAs products providing opportunities for growth and jobs at Local, National and European levels. - deploy a key environmental product obtained with smarter and greener processes addressing the challenge of resource scarcity, water and soil pollution.

Keywords: bio polymer,bio plastic,bio based,biodegradable,industrial scale up,technical and economic feasibility
NPX-101 is a portable home device for the treatment of moderate to severe depression, boasting more effective and safer outcomes, based on information deposited and received from the Cloud. (NPX-101)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: United Kingdom,United Kingdom
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

Over 450 million individuals face depression, with over 800,000 suicide deaths per year, delivering a death rate of one person every 40 seconds. These figures are set to increase as estimates put 1 out of 4 individuals in the future to face similar mental disorders at some stage of life. NPX-101 is the first product line for treating moderate to severe depression, especially the 30% of patients who are currently drug-resistant. It is a patented non-invasive bioelectronic device that delivers Transcranial Magnetic Stimulation (TMS) in the form of a wearable Magnetic Resonance Imaging (MRI) helmet with shield protection. It delivers more precise and deeper energy stimulation, for fuller more effective therapy, removing the side-effects and other treament discomforts with current day treatment. Phase 1 of the SME instrument fits into the overall company plan of NeuroPrex and Omsbar to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of the NPX-101. It would importantly help to deduce the quickest routes of distribution and market uptake for its entry-point of the U.K.

Keywords: depression,mental disorder,drug dependency,transcranial magnetic stimulation,homecare
iReact-NG (iReact-NG)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Greece
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-08-01
End date: 2017-11-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Apart from presenting major benefits, the increase of RES installations in the electricity grid brings certain technological challenges, such as power supply and demand imbalance, and voltage instability, which in certain cases, drives to poor delivered electricity product. Based on ICT, AI and automation technologies, the “smart-grid” appears as a disruptive methodology able to regulate the complicated energy distribution landscape. Today, EMTECH offers the iReact (www.ireact.gr), as a smart-grid component to facilitate automated reactive load compensation in power distribution substations. The solution has been adopted by the Greek Transmission System Operator, and is now installed in more than 150 substations. The achieved benefits are 8% reduction in energy losses, 15% increase of released system capacity, remote monitoring, alerting and control. The objective of the proposed innovation by enhancing iReact (iReact 2.0), is to introduce in the market a real-time decision support & control tool for optimized operations in distribution grids, i.e. to extent utilization of the solution, not only in the distribution substation, but into the distribution grid as well. Based on real-time parallel simulations (near-future), fused with historical information (past), and real-time measurements and control (present), the tool shall inform smart-grid operators about near-future optimized operational scenarios, along with statistical possibilities to happen and the estimated benefits if applied. The application, either automatically or after user’s approval, shall remotely command all distributed controllers, installed in the distribution substation & RES and shall apply the selected operational scenario. Benefits achieved shall be optimum performance of the distribution grid, higher energy loss savings (up to 15-20%) thus reduction of CO2 emissions, better electricity delivered to end-users, and harmonization of the operational interaction between utilities and RES.

Keywords: smart grid,co simulation,decision support,voltage stability,power balance,power distribution substation,energy saving,smart inverters,capacitor bank,short term load forecast
High Level eHealth Conference 2017 (EHW17)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Action type: Coordination and support actions
Countries involved: Malta
Call: Presidency events - eHealth (H2020-IBA-SC1-eHealth-2017, 2017)
Start date: 2017-03-01
End date: 2017-06-30
Duration (months): 4.0
Total project cost (EUR): 301371.5
EU funding (EUR): 300000.0
Participants: 1
Project status: CLOSED

The Maltese Presidency proposes to organise a High-Level Conference on eHealth in keeping with the practice established by first-semester Presidencies since 2007. The main objective will be to bring together high-level policymakers from all EU MS and other key stakeholders to discuss the most important current issues of common interest regarding the effective, safe and economic application of ICT to the planning, delivery and evaluation of health services. High-level delegates will be invited from all EU MS, Switzerland, Norway, Iceland & USA. The Presidency will co-locate the event with a Health IT conference & exhibition organised by HIMSS Europe. Partnering with HIMSS will help reach a wider and more diverse audience, including key stakeholders from the health IT industry, allowing EU eHealth policies and the outcome of relevant EU-funded research and innovation to reach a wider audience. The co-located events will be known collectively as “eHealth Week 2017” (EHW17). The EHW17 programme will be both diverse and comprehensive, highlighting developments taking place in various aspects of eHealth such as legal, organisational, semantic and technical. The overarching theme of EHW17 is “Data for Health: the key to personalised sustainable care”. Subjects discussed will include: - Patient access to and sharing of health data - Moving health data safely onto cloud infrastructure - Sharing personal health data across country borders - Improving effectiveness, safety and privacy of mHealth - Scaling up digital innovation for health and care - International cooperation in eHealth - Smart environments & integrated care - Data management and analytics for personalised medicine & public health policy EHW17 will include an Informal Working Lunch for high-level delegates, during which they will be invited to discuss the health-related aspects of the mid-term review of the Digital Single Market. Both Presidency and Commission will have a stand on the exhibition floor.

Keywords: ehealth conference malta presidency
Pan-European Open Innovation Network for Corporate Challenges in advanced technologies (PITCCH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany,Italy,Netherlands,Portugal
Call: European Open Innovation network in advanced technologies (H2020-INNOSUP-2019-07, 2019)
Start date: 2020-05-01
End date: 2023-04-30
Duration (months): 36.0
Total project cost (EUR): 1498995.0
EU funding (EUR): 1498995.0
Participants: 5
Project status: SIGNED

Advanced technologies are key drivers towards transformation and efficiency of industry. Today behind every innovation is a complex and high-tech supply chain where SMEs have an important role to foster invention. Their role of drivers of innovation mainly happen through collaborations with large enterprises (LEs). However, getting SMEs engaged with LEs and vice versa still encounters some barriers. Major challenges are related with finding interesting innovations and connecting them through trustful and beneficial collaborations. The PITCCH project aims to build a pan-European open innovation network to support the establishment of structured collaborations between innovative SMEs and LEs to take up their advanced technologies-based solutions, by intermediating the connection between needs and cutting-edge offers. The PITCCH consortium intends to build a well-reputed network ecosystem gathering technology centres, LEs and SMEs. Actors will be attracted from partners’ networks and from other existing European initiatives, such as the EEN, the DIH catalogues, the KET observatory, the SME Instrument Hub. To create a critical mass of partnerships, selected LEs will launch 15 Corporate Challenges to call for SMEs. After a selection, best SMEs will be supported by the PITCCH support schemes to develop their projects. A Digital Open Innovation Platform will be developed to serve as the central brokerage service point, enabling an efficient functioning of the network. The platform will support the members of the network in scouting potential partners and in managing the requests for brokerage services. A brokerage services portfolio will be set up based on the competences of TCs and the needs of companies. To achieve the final objective of long-term sustainability of the network, three different business models as support schemes to Open Innovation partnerships will be tested. By the end, the most sustainable will be chosen as base to build a PITCCH Sustainability Plan.

Keywords: open innovation,advanced technologies,key enabling technologies,smes,large enterprises,technology centers,corporate challenges,pitch,network ecosystem,sustainable business models
Fully implantable patient-specific Artificial Hearts without External Power (BloodTurbine)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Türkiye
Call: Call for proposals for ERC Proof of Concept Grant (ERC-2020-PoC, 2020)
Start date: 2021-11-01
End date: 2023-10-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Patient population with end-stage heart failure in the EU grows by 5M annually. Due to donor shortage, only a handful of patients ever receive cardiac transplantation. Unfortunately, this results in 250K deaths every year. Long-term mechanical circulatory support (MCS) is a solution, but external power needs result in driveline infections and bulky systems limiting patient mobility. An innovative blood turbine device emerged from the parent ERC that can overcome these limitations. This novel turbine can drive MCS by transferring the available cardiovascular energy to the diseased site without the need of external power. The proposed passive concept (at TRL 6-7) will realize the long-sought use of ventricle assist devices (VAD) as a destination therapy. PoC project will enable the timely translation of a disruptive device to the bedside, by completing device optimization, comparative analysis and key preclinical experiments in accordance with the new MDR regulatory framework. Business development, valuation and IPR activities are also budgeted. Elimination of the bulky power systems and control units allowed three-dimensional printing of this artificial heart from biocompatible resins. This resulted a new “customized” VAD concept that can be precisely tailored for each individual patient needs. Furthermore, the comparatively low product cost (€1K vs. €120K) will allow access to a major untapped global market reaching 18 million people annually, as many developing countries have no access to expensive MCS systems. These intriguing business opportunities will be validated, and major commercialization tasks will be completed through a strong team of business mentors, clinicians and cardiovascular device experts. In addition to the adults with right-heart failure, the developed device will improve the post-operative quality life of children with heart defects that require staged cardiovascular surgeries. Socioeconomic impacts span both the patients and their families.

Keywords: cardiovascular engineering,ventricle assist devices,hemodynamics,congenital heart defects,pediatric cardiovascular surgery,blood pumps,artificial heart
Three-dimensional nanoelectrochemical systems based on low-cost reduced graphene oxide: the next generation of water treatment systems (ELECTRON4WATER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Spain
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-05-01
End date: 2023-06-30
Duration (months): 74.0
Total project cost (EUR): 1493734.0
EU funding (EUR): 1493734.0
Participants: 1
Project status: SIGNED

The ever-increasing environmental input of toxic chemicals is rapidly deteriorating the health of our ecosystems and, above all, jeopardizing human health. Overcoming the challenge of water pollution requires novel water treatment technologies that are sustainable, robust and energy efficient. ELECTRON4WATER proposes a pioneering, chemical-free water purification technology: a three-dimensional (3D) nanoelectrochemical system equipped with low-cost reduced graphene oxide (RGO)-based electrodes. Existing research on graphene-based electrodes has been focused on supercapacitor applications and synthesis of defect-free, superconductive graphene. I will, on the contrary, use the defective structure of RGO to induce the production of reactive oxygen species and enhance electrocatalytic degradation of pollutants. I will investigate for the first time the electrolysis reactions at 3D electrochemically polarized RGO-coated material, which offers high catalytic activity and high surface area available for electrolysis. This breakthrough approach in electrochemical reactor design is expected to greatly enhance the current efficiency and achieve complete removal of persistent contaminants and pathogens from water without using any chemicals, just by applying the current. Also, high capacitance of RGO-based material can enable further energy savings and allow using intermittent energy sources such as photovoltaic panels. These features make 3D nanoelectrochemical systems particularly interesting for distributed, small-scale applications. This project will aim at: i) designing the optimum RGO-based material for specific treatment goals, ii) mechanistic understanding of (electro)catalysis and (electro)sorption of persistent pollutants at RGO and electrochemically polarized RGO, iii) understanding the role of inorganic and organic matrix and recognizing potential process limitations, and iv) developing tailored, adaptable solutions for the treatment of contaminated water.

Keywords: electrochemical water treatment,reduced graphene oxide coated electrode materials,persistent organic contaminants removal,disinfection