Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Geothermal Emission Control (GECO)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Iceland,Germany,Italy,Italy,Germany,Spain,Spain,Italy,Türkiye,Türkiye,Norway,France,France,Netherlands,United Kingdom
Call: Demonstrate solutions that significantly reduce the cost of renewable power generation (H2020-LC-SC3-2018-RES-SingleStage, 2018)
Start date: 2018-10-01
End date: 2023-03-31
Duration (months): 54.0
Total project cost (EUR): 18057520.41
EU funding (EUR): 15599842.88
Participants: 24
Project status: SIGNED

GECO will advance in the provision of cleaner and cost-effective non-carbon and sulphur emitting geothermal energy across Europe and the World. The core of this project is the application of an innovative technology, recently developed and proved successfully at pilot scale in Iceland, which can limit the production of emissions from geothermal plants by condensing and re-injecting gases or turning the emissions into commercial products. To both increase public acceptance and to generalise this approach, it will be applied by GECO in four distinct geothermal systems in four different European countries: 1) a high temperature basaltic reservoir in Iceland; 2) a high temperature gneiss reservoir in Italy; 3) a high temperature volcano-clastic reservoir in Turkey; and 4) a low temperature sedimentary reservoir in Germany. Gas capture and purification methods will be advanced by lowering consumption of resources, (in terms of electricity, water and chemicals) to deliver cheaper usable CO2 streams to third parties. Our approach to waste gas storage is to capture and inject the soluble gases in the exhaust stream as dissolved aqueous phase. This acidic gas-charged fluid provokes the dissolution of subsurface rocks, which increases the reservoir permeability, and promotes the fixation of the dissolved gases as stable mineral phases. This approach leads to the long-term environmentally friendly storage of waste gases, while it lowers considerably the cost of cleaning geothermal gas compared to standard industry solutions. A detailed and consistent monitoring program, geochemical analysis, and comprehensive modelling will allow characterising the reactivity and consequences of fluid flow in our geologically diverse field sites letting us create new and more accurate modelling tools to predict the reactions that occur in the subsurface in response to induced fluid flow. Finally, gas capture for reuse will be based on a second stage cleaning of the gas stream, through amine separation and burn and scrub processes, producing a CO2 stream with H2S levels below 1 ppm, which is the prerequisite for most utilisation pathways such as the ones that will be applied within the project.

Keywords: carbon,geothermal,gases,mineralisation,utilisation
Trained immunity: improving the next generation of vaccines for the older generation (TRAIN-OLD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Greece,Netherlands
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2262500.0
Participants: 3
Project status: SIGNED

The host defense, especially the adaptive immunity, is defective in the elderly, with a dramatic drop for the efficacy of vaccination with old age. Interestingly however, the innate immunity of older individuals is relatively intact, and we recently described that epigenetic and functional reprogramming of innate immune cells by certain vaccines and mild infections, termed ‘trained immunity’, induces potent heterologous protection against infections. I propose that induction of trained immunity is an important novel approach to improved vaccination in the elderly. Induction of trained immunity is regulated by the interaction between the host genome, microbiome, and the epigenetic and metabolic programs of specific populations of myeloid cells, and we need to understand how these factors are impacted by age and gender of the host. By understanding the factors that impact the response to BCG (Bacille Calmette-Guerin), the prototype vaccine that induces trained immunity, we will be able to design better vaccines for the elderly. The Key objectives of the project are: Key objective 1: To describe the innate immune cell (sub)populations, and their heterogeneity at single-cell level, responsible for mediating trained immunity in the young and elderly adults. Key objective 2: To identify the complex genetic, epigenetic, microbiome, and metabolic programs that represent the molecular and biochemical substrates of trained immunity in the myeloid cells of the elderly individuals. Key objective 3: To use systems biology to map the heterogeneity of trained immunity response determined by host (epi)genome, microbiome, and environmental factors in the elderly. Expected results: We will understand the main cellular and molecular mechanisms for the induction of trained immunity responses in vivo and the specificities of the response in the elderly. These findings will enable the design of innovative approaches to improve vaccination strategies.

Keywords: immune senescence,vaccination,innate immune memory,trained immunity
CONCEPT OF OPERATIONS FOR EUROPEAN U-SPACE SERVICES - EXTENSION FOR URBAN AIR MOBILITY (CORUS-XUAM)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Spain,Austria,Germany,Germany,Spain,Italy,Germany,Germany,Italy,Sweden,Belgium,Belgium,Belgium,Slovenia,France,France,France,France,United Kingdom,United Kingdom,Denmark
Call: U-space capabilities and services to enable Urban Air Mobility (H2020-SESAR-2020-1, 2020)
Start date: 2021-01-01
End date: 2023-04-30
Duration (months): 28.0
Total project cost (EUR): 6621104.71
EU funding (EUR): 3999389.0
Participants: 32
Project status: SIGNED

CORUS-XUAM is a 24-month VLD project that will demonstrate how U-space services and solutions could support integrated Urban Air Mobility (UAM) flight operations, allowing eVTOLs/UAS and other airspace users (unmanned and manned) to operate safely, securely, sustainably and efficiently in a controlled and fully integrated airspace, without undue impact on operations currently managed by ATM. The project is proposed by the consortium that delivered the SJU CORUS U-space Concept of Operations (ConOps) in 2019, extended by the addition of UAM expertise. The activities will start with the update of the U-space ConOps, addressing the integration of UAM/UAS operations into the airspace, also identifying new U3/U4 services. The project activities will continue with the preparation and execution of six challenging VLD campaigns in six different European locations. These VLD activities will be at the heart of CORUS-XUAM and will support integrated operations of UAS/UAM and manned aircraft, and advanced forms of interaction through digital data exchange supported by integrated and advanced U-space services in urban, sub-urban, and inter-city scenarios as well as in and near ATM-controlled airspaces and airports. The VLDs will focus on different types of mission, such as passenger transport, logistic, delivery, emergency response and surveillance, using different U-space deployment architectures and state-of-the-art technologies. They will consider coordination between ATC and U-space, including interaction with ATCOs and pilots. The VLDs will combine flights by eVTOLs with other traffic and operations in the CTRs of major airports. Vertiport procedures, separation, and data services will be also demonstrated. The main results will be used to further consolidate the ConOps at the end of the project. The project will also involve extensive consultation and communication initiatives with reference Authorities, U-space stakeholders and end-users.

Keywords: u space,drone,urban air mobility,evtol,ectol,concept of operations,conops,architecture,social,demonstration
Spin-polarized Catalysts for Energy-Efficient AEM Water Electrolysis (SpinCat)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Israel,Spain,Netherlands,Portugal
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-06-01
End date: 2025-05-31
Duration (months): 48.0
Total project cost (EUR): 3358238.75
EU funding (EUR): 3358238.75
Participants: 5
Project status: SIGNED

For Europe to achieve climate neutrality by 2050, H2 has been identified as one of the priority areas for clean, affordable and secure energy to replace oil and gas, in accordance with the European Green Deal. Water electrolysis using renewable energy is the leading energy storage contender as a clean H2 source to establish a sustainable H2 economy. However, the necessity of using rare and expensive platinum groups metals (PGMs) to catalyse the cathodic hydrogen evolution reaction (HER) and the anodic oxygen evolution reaction (OER) hinders the wide implementation of water electrolysis. Therefore, the development of efficient PGM-free catalysts is of utmost importance for Europe to reach its decarbonization objectives. SpinCat addresses this need by realizing a new class of magnetic earth-abundant catalysts that, through spin polarization, will boost catalytic activity towards OER by a factor of three as compared to state-of-the-art catalysts. Further enhancements to catalytic activity will be obtained through the use of external magnetic field during catalysis. Through an interplay of experiment and theory, we will design and prepare catalyst materials featuring optimal spin polarization effects, gain fundamental knowledge on the parameters affecting the OER activity of magnetic materials, and develop a general theoretical model for the overall description of the influence of the electron spin in electrocatalysis. The technology will be demonstrated in a magnetically enhanced anion-exchange membrane (AEM) electrolyser prototype, which merges the benefits of both internal and external magnetic effects. The long-term vision of SpinCat is to establish cost-effective H2 production via reducing the cost of membrane-based electrolyser technology by omitting the need of PGMs. This project will contribute to establishing Europe as the world leader in electrolyser technology for renewable H2 production.

Keywords: spin polarization,electrocatalysis,oxygen evolution reaction,anion exchange membrane
MOBILITY BASED ON AGGREGATION OF SERVICES AND APPLICATIONS INTEGRATION (MASAI)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Countries involved: Germany,Belgium,France,Netherlands,Portugal
Call: Towards seamless mobility addressing fragmentation in ITS deployment in Europe (H2020-MG-2014_TwoStages, 2014)
Start date: 2015-06-01
End date: 2018-05-31
Duration (months): 36.0
Total project cost (EUR): 3309968.75
EU funding (EUR): 3309968.75
Participants: 5
Project status: CLOSED

MOBILITY BASED ON AGGREGATION OF SERVICES AND APPLICATIONS INTEGRATION MASAI addresses the interconnection of digital services to facilitate mobility in heterogeneous and varying environment. MASAI designs, prototypes and pilots in the field a MObility Open Network of Services (MOONS) as an interconnected distributed environment, on which any service module can be easily plugged to interact with others (using principles such as DNS-SD). MASAI feeds the mobile apps ecosystem. MASAI investigates also app-2-app direct communication, app being able to call/feed other apps (iOS 8 promise). MASAI is an alternative to having centralized integration platforms – showing their limits. MOONS is then instrumental in favouring plug & play services (trip planners, ticketing, community services, infotainment,…) in an open ecosystem. In this way, a “Concierge” app (or access app which is the user entry point, a trip-planner for example) in a NFC Phone address the citizen need by combining output of several services related to ticketing , trip planners, city guide, etc, provided by modules from service operators. A set of existing (SIRI, NETEX,…) and under development (such as TS13149-part9) standards are paving the way. MASAI in return will target results that may feed this standardization process. MASAI vision is supported by a consortium composed by innovative SMEs previously involved in such developments (MTA, DIGIMOBEE, CARD4B, CHESS IX), completing partial approaches by enlarging the full scope to the mobility eco-system within a plug & play mobility services vision. It includes DB Systel (Deutsche Bahn - IT) as a key user reference which has identified MASAI as an open, innovative and consistent approach for building a seamless services experience for their customers, open to any applications supplier. MASAI vision is demonstrated in a variety of environments inducing cross-fertilisation in terms of delivery of independent plug & play services capable of being aggregated on any MASAI environment through open and public specifications.

Keywords: mobility,digital services,open system arquitectures,ticketing,travel information
Sodium-Zinc molten salt batteries for low-cost stationary storage (SOLSTICE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Spain,Italy,Germany,Switzerland,Norway,Switzerland,Switzerland,United Kingdom,Portugal
Call: Next-generation batteries for stationary energy storage (H2020-LC-BAT-2020, 2020)
Start date: 2021-01-01
End date: 2025-06-30
Duration (months): 54.0
Total project cost (EUR): 7720798.75
EU funding (EUR): 7720798.75
Participants: 12
Project status: SIGNED

SOLSTICE answers the quest for stationary energy storage with two Na-Zn molten salt batteries, which operate at elevated temperature. The first concept benefits from the existing and successful ZEBRA® technology. Replacing their Ni-electrode by cheap and abundant Zn will only minimally affect other system parts thereby ensuring fast commercialisation. The second approach, an all-liquid cell, will apply the same chemistry, but does not require a ceramic electrolyte thus reducing cost further. Both battery concepts shall be brought to TRL5, and validated by four demonstrators, operating in a realistic environment at the end of the 4-year project. The demonstrators will be equipped with a self-learning battery management system and will be accompanied by upscaling, system integration and public acceptance studies. Na-Zn technology is exceptionally performant as it promises similar efficiency and depth of discharge as Li-ion cells, but extreme current densities. Featuring molten electrodes, Na-Zn cells actually work better when being cycled, as operation keeps them warm; several cycles per day and a lifetime exceeding 10,000 cycles can be legitimately expected. Na-Zn storage is perfectly sustainable: the raw materials, table salt and Zn, are abundant in the EU, cheap and not harmful. The environmental impact of Zn-mining and battery production is expected to be minimal. Finally, recycling is greatly simplified due to the large, molten electrodes. The most valuable element, Zn, can simply be recovered as pure metal and reused after dismantling the cells. Based on the existing knowledge on ZEBRA® battery production, the storage price of Na-Zn batteries is expected to approach 1 cent/kWh/cycle by 2030 - including balance-of-plant and recycling cost. Summing up, the Na-Zn technology is the cheapest molten-salt battery, is fully sustainable, fulfils all criteria of the call - and is even realistic to be commercialised by 2030.

Keywords: high temperature cell,electrochemical energy storage,molten salt battery,zebra battery
Civic community and public space in the ancient Near East. The case of Hittite Anatolia at the end of the Late Bronze Age (14th-13th centuries BCE). (COMPUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-11
End date: 2019-01-10
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

This project proposes to study public space of the ancient Near Eastern cities as a material correlate of civic communities. Civic communities acted as a significant political factor throughout the history of the ancient Near East, both as institutions (e.g., assemblies) and as informal groups (the “town's crowd”). These forms of social aggregation were influential and often antagonistic alternatives to the monarchical and religious central powers. However, while the Temple and the Palace as architectonic materializations of dominant powers engaged entire generations of archaeologists, the traces left by civic communities in the urban texture of the ancient cities have received far less attention. This project approaches the study of past communal political life by analyzing the planning and use of central streets and squares at Hattusha, the capital of the Hittite Empire. The study is based on a granted access to unpublished topographical data and integrates three lines of methodological inquiry: topological analysis, urban design analysis, and ta "contextual analysis". Both heuristics and time focus originate from my previous studies on Syro-Hittite urbanism in the early Iron Age (1200-900 BCE). I came to understand that Late Bronze Age (14th-13th centuries BCE) urban politics are the key to city structure and political discourses for centuries to come. As case-study, Hattusha offers an optimal balance of historical relevance and data accessibility. The research aims at opening vistas on the interaction between built environment, informal civic habits, and communal institutions. It places itself across archaeology, anthropology, and urban studies. As a result, I expect an output of relevance not only for archaeologists, but for all scholars interested in comparative urban politics, ancient and modern. I also designed this research in collaboration with Ca' Foscari University to lay ground for future European-based research projects sharpen my career profile.

Keywords: ancient near east,late bronze age,anatolian studies,urban design,social analysis of space,history of architecture,ancient governance,assembly democracy,collective identities
Dissecting the role of Translational Regulation in Tumorigenesis (TRANSREG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Switzerland,Switzerland
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-08-01
End date: 2024-04-30
Duration (months): 69.0
Total project cost (EUR): 1977148.0
EU funding (EUR): 1977148.0
Participants: 2
Project status: SIGNED

The control of translation is a key determinant of protein abundance, which in turn defines cellular states. The impact of translational regulation may be even greater during the transition from homeostasis to malignancy, as revealed by the surprisingly low correlations between mRNA and protein levels in human cancer databases. This raises the intriguing possibility that through an ability to generate aberrant downstream networks of translational regulators, oncogenic drivers might impose altered protein synthesis programs that become the driving force for tumor formation and malignant progression. We recently unveiled a hitherto unappreciated role for upstream open reading frame (uORF) translation in tumorigenesis and unearthed a novel switch from conventional EIF2 initiation factor-mediated to alternative EIF2A-mediated uORF translation. These observations suggest that uORFs constitute an exciting new frontier in the field of translational regulation with the potential to fundamentally impact cellular fate. Here, I propose to systematically analyze the function of uORFs during tumorigenesis. First, we will conduct an in vivo CRISPR/CAS9-based screen in mice to elucidate the role of thousands of uORFs in development, differentiation and upon oncogenic transformation. Second, focusing on select uORFs surfacing in the screen, we will document their role during tumor initiation and progression. Third, we will develop novel tools to detect uORF translation in vivo, exploit them to monitor uORF translation during different stages of tumorigenesis, gain mechanistic insight into their function and finally test the relevance of these findings in human cancer. Collectively, these approaches will provide unprecedented and comprehensive insight into the function of uORFs, unravel new paradigms in the control of gene expression and expose novel strategies for cancer diagnostics and treatment.

Keywords: translational regulation,upstream open reading frames,crispr screening