Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SILKNOW. Silk heritage in the Knowledge Society: from punched cards to big data, deep learning and visual / tangible simulations (SILKNOW)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Reflective societies - cultural heritage and European identity
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Spain,Spain,Slovenia,Poland,France,France,France
Call: European cultural heritage, access and analysis for a richer interpretation of the past. (H2020-SC6-CULT-COOP-2017-two-stage, 2017)
Start date: 2018-04-01
End date: 2021-08-31
Duration (months): 41.0
Total project cost (EUR): 2390060.5
EU funding (EUR): 2390060.5
Participants: 10
Project status: CLOSED

Silk was a major factor for progress in Europe, mostly along the Western Silk Road’s network of production and market centres. Silk trade also allowed for exchange of ideas and innovations. Punched cards were first used in Jacquard silk looms, long before modern computers were even imagined. Today, too, fashion and high-end textile industries have a huge impact in the EU, reaching €525 billion in annual turnover. Silk, however, has become a seriously endangered heritage. Although many European specialized museums are devoted to its preservation, they usually lack size and resources to establish networks or connections with other collections. SILKNOW aims to produce an intelligent computational system that goes beyond current technologies in order to improve our understanding of European silk heritage. This legacy will be studied, showcased and preserved through the digital modelling of its weaving techniques (a “Virtual Loom”). Users will access the resulting information through visual and tangible simulations, and experience vastly enhanced search tools, providing better results through automatic visual recognition, advanced spatio-temporal visualization, multilingual and semantically enriched access to existing digital data. Thus, SILKNOW will improve the understanding of EU heritage and its rich diversity, applying next-generation ICT research to the needs of various users (museums, education, tourism, creative industries, media…), and preserving an intangible heritage (ancient weaving techniques) for younger generations. Its research activities and outputs will have direct impact in computer science and big data management, focusing on searching digital content in heterogeneous, multilingual and multimodal databases. SILKNOW will be possible only with the close cooperation of a multidisciplinary team, including areas as ICT, text analytics, image processing, semantics, big data, 3D printing, art history, terminology, textile fabrication and conservation.

Keywords: deep learning,text analytics,ontology,thesaurus,3d printing,silk textiles
Automatic inspection of lyophilized preparations through innovative ICT control system (LYO-CHECK)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Italy
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2016-11-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 2452558.75
EU funding (EUR): 1716791.13
Participants: 1
Project status: CLOSED

The aim of LYO-CHECK project is to create two machines, one pilot machine and one fully automatic industrial machine, for the inspection of lyophilized pharmaceutical preparations intended for injection, based on the two elements of: a) an innovative vision architecture (dedicated software and optical layout); b) an ancillary technology (head space gas analysis) for testing the sterility of the product via container integrity inspection. Pharmaceutical products intended for injection, also called PARENTERALIA, are becoming more and more commonly found in lyophilized form and this trend appears to grow steadily, especially for anti-infectives, biotechnology derived products, and in-vitro diagnostics. In fact, the lyophilized product shows the following characteristics: - Long term storage (more than two years), even at room temperature if stored properly; - Protection from pollution due to microorganisms activity ; - Ease of transport and storage; - Rapid reconstitution of the product in contact with the appropriate solvent; - preservation of the original product features. Nevertheless, the quality-control inspection of products in lyophilized form pose peculiar challenges, needing a dedicated system which is totally different from the one so far applied to inspect parenteral products in liquid form. During the LYO-CHECK project, the pilot and industrial machines will be used for demonstration in operational environment with trials on potential customer’s products. LYO-CHECK project is based on a sound technical and economical/financial feasibility study, and will allow Antares Vision to increase market share in Europe and worldwide with this breakthrough innovation, with a high impact in terms of increased turnover and employment rate.

Keywords: inspection machine,lyophilized pharmaceutical preparations,ict innovation,non destructive in process control,freeze dried product,parenteralia
Harmless Clostridium bacteria as a highly targeted, continuous delivery system for immunomodulatory anti-cancer drugs (CMI2T IA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Netherlands
Call: European SME innovation Associate - pilot (H2020-INNOSUP-02-2016, 2016)
Start date: 2017-09-01
End date: 2018-08-31
Duration (months): 12.0
Total project cost (EUR): 115625.0
EU funding (EUR): 115625.0
Participants: 1
Project status: CLOSED

DualTPharma (DTP) is a new venture developing a highly-potent and proprietary line of targeted pharmaceuticals for personalised cancer treatment. Our mission is to broaden our current pipeline by developing a new class of dual drugs for cancer treatment which are well tolerated and can be taken orally. This novel solution comprises the application of non-pathogenic Clostridium bacteria as a novel tumour delivery vehicle for anti-cancer drugs to increase immunotherapy efficacy. Even though DTP has a multi-disciplinary team available in the oncology field, we lack the required expertise and skills in the bacterial genetic field to test the feasibility and lead the development of this new line of R&D. Therefore, the goal of this project, CMI2T IA, is to hire an Innovation Associate with expertise in the bacterial genetic field for our company, to determine the feasibility of this novel solution. The successful candidate is preferably a microbiologist with an interest in bacterial applications in cancer treatment and with strong expertise in bacterial genetics. During the first 12 months, the innovation associate will be involved with both technical and business-related activities. (S)he will be responsible for establishing the new line of R&D, with activities ranging from establishing and managing a new lab to, planning research, to performing hands-on laboratory work. More specifically, the research activities will include genetic modification of bacteria, and performing in vitro efficacy assays on human cell lines. From a business perspective, the Innovation Associate will critically contribute to a market study and the development of a business strategy of the new business unit. This position will open up new career opportunities for the Innovation Associate, by obtaining transferable skills in both the business and technical field, and will leverage DTP’s growth by expanding DTP’s drug pipeline with a very novel and promising cancer drug delivery candidate.

Keywords: cancer immunotherapy,clostridium,drug delivery
Synaptic Dysfunction in Neuropsychiatric Disorders (Syn2Psy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Switzerland,France,Portugal,United Kingdom,United Kingdom,Denmark,Portugal
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-03-01
End date: 2023-08-31
Duration (months): 54.0
Total project cost (EUR): 3885134.08
EU funding (EUR): 3885134.08
Participants: 11
Project status: SIGNED

The large public health burden and individual suffering associated with mental disorders speaks to the need to study their biological underpinning. Genetic research, animal models of disease and human neuroimaging studies have provided convergent evidence to common pathways implicated in their aetiology, namely pathways that regulate synapse development and plasticity, which result in abnormal structural and functional connectivity in the brain of neuropsychiatric patients. The time has come to integrate studies across different levels, leading to the identification of signatures of illness associated to specific risk pathways, which can drive the development of novel therapies. The objective of Syn2Psy is to provide high-level Ph.D. training for 14 early stage researchers (ESRs) to answer three critical questions: 1) What are the synaptic defects at the basis of neuropsychiatric disorders? 2) Which are the neuronal circuits that are disrupted, and may be targets for therapies? 3) How and when can we modulate the course of disease? Syn2Psy combines strong scientific with complementary know-how from the non-academic sector, and network-wide actions on scientific and complementary soft skills, to train a new generation of high achieving ESRs and provide them with the transferable skills necessary for thriving careers in a flourishing area. Industrial partners Lundbeck, Eurotrials and ZEISS provide experience on drug, clinical trials and technology development, the Coimbra University Hospital will expose the students to clinical research, while the clinic for child development PIN and the Marionet theatre company offer training in societal awareness and outreach. The excellent basic scientific knowledge and diverse skills acquired by ESRs will enhance their employment prospects in both the academic and non-academic sectors, and their scientific contributions will inform novel therapeutic approaches for alleviating this leading cause of disability worldwide.

Keywords: neuropsychiatric disorders,synaptic dysfunction,genetic animal models of disease,rational,therapies,neuromodulators
The makeup of the modern horse: a history of the biological changes introduced by human management (PEGASUS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: France,Denmark,United Kingdom
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-12-01
End date: 2022-11-30
Duration (months): 72.0
Total project cost (EUR): 1999555.0
EU funding (EUR): 1952961.25
Participants: 3
Project status: CLOSED

The horse provided us with rapid transportation, an almost unrivaled secondary product that tremendously impacted the politico-economical trajectory of our societies, revolutionizing the circulation of ideas, people, languages, religions and communication. Horse chariotry and cavalry also changed warfare and beyond the battlefield new equestrian technologies have stimulated agricultural productivity. However, the 5,500 year long history of horse domestication and management, which transformed the natural evolutionary trajectory of wild horses into the more than 625 domestic breeds living today, is difficult to reconstruct from archaeology, history and modern genetics alone. Yet, with archaeogenetics, one can access the genetic information from past individuals and track in great detail past population trajectories. In this project, I propose to build on the latest advances in the analysis of ancient DNA molecules to gather new genomic, epigenomic and metagenomic information from ancient horses. This will be integrated with archaeozoological, isotopic and historical data to enhance our understanding of the multiple processes underlying the transformation of the animal that perhaps most impacted our history. Starting from the characterization of pre-domestic populations of wild horses, I will evaluate the genomic and dietary impact of early domestication stages and will explore whether horses were independently domesticated in Iberia and the Pontic-Caspian steppe. I will follow how the emergence of chariotry and the development of heavy cavalry impacted the horse’s behavioural, physiological and biological makeup. I will reveal the horse characteristics that were preferred in various historical contexts and will investigate a diversity of management strategies and husbandry conditions to reveal their impact on horses, from classical and late antique periods until the recent creation of modern breeds by means of intensive selective breeding.

Keywords: ancient dna,horse domestication,animal management,animal husbandry,evolutionary genomics,diet,artificial selection,natural selection,biological adaptation
Understanding and measuring SUb-23 nm particle emissions from direct injection engines including REAL driving conditions (SUREAL-23)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Research and Innovation actions
Partnership: EGVI (cPPP)
Countries involved: Italy,Italy,Spain,Switzerland,Greece,France,Denmark,United Kingdom
Call: Technologies for low emission light duty powertrains (H2020-GV-2016-INEA, 2016)
Start date: 2016-10-01
End date: 2019-12-31
Duration (months): 39.0
Total project cost (EUR): 3706212.5
EU funding (EUR): 3428712.5
Participants: 8
Project status: CLOSED

A large proportion of the total number of particles emitted from direct injection engines are below 23 nm and although the EU aims to regulate those emissions and impose limits for new light duty vehicles, this is not yet possible due to the absence of accurate quantification methods, especially under real driving conditions. The main reason for this is the absence of adequate knowledge regarding the nature of sub-23 nm particles from different engine/fuel combinations under different operating conditions. SUREAL-23 aims to overcome such barriers by introducing novel measurement technology for concentration/size/composition measurements. The recently established supercontinuum laser technology will be coupled to photoacoustic analysis and will also be employed for photoelectric ionization aerosol charging to achieve real-time, composition size-specific analysis of the particles. In parallel, state of the art aerosol measurement techniques will be advanced for better compatibility with sub-23 nm exhaust particles as well as on-board use. The developed instrumentation will assess sub-23 nm particle emissions from both Diesel and GDI vehicles accounting for effects of the fuel, lubricants, aftertreatment and driving conditions for existing and near-future vehicle configurations. The most suitable concepts will be developed for PN-PEMS applications and evaluated accordingly. The project will provide measurement technologies that will complement and extend established particle measurement protocols, sustaining the extensive investments that have already been made by industry and regulation authorities. The project will deliver systematic characterization of sub 23-nm particles to facilitate future particle emission regulations as well as to assess any potential trade-off between advances in ICE technology towards increased efficiency and emissions. The consortium consists of European and US organisations, which are leaders in the field of aerosol and particle technology.

Keywords: sub 23 nm particle emissions,sub 23 nm particle composition measurement,size specific number based particle measurements,pn pems,regulation of ultra fine particle emissions
First Steps in Mirror Symmetry for Generalized Complex Geometry (FuSeGC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Belgium,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2024-08-31
Duration (months): 36.0
Total project cost (EUR): 266425.92
EU funding (EUR): 266425.92
Participants: 2
Project status: SIGNED

Generalized complex geometry unifies complex and symplectic geometry, two important research areas in modern pure mathematics. While generalized complex (GC) structures in full generality are not yet well-understood, a number of important results from complex or symplectic geometry have already been extended to these more general structures. Further, complex and symplectic geometry are intimately related to each other via mirror symmetry, a conjectured duality between certain complex and symplectic manifolds discovered in theoretical physics in the context of string theory. This duality has been proven in special cases. For this project I propose an approach to extend homological mirror symmetry to certain subclasses and examples of GC manifolds, centred around three objectives: (O1) Quantify the effect of stable GC compactifications of Landau-Ginzburg mirrors of del Pezzo surfaces on their Fukaya category. (O2) Construct a Wrapped Fukaya category for oriented surfaces with log symplectic structures. (O3) Develop and study a notion of 'holomorphic families of Fukaya categories'. In particular in the case of (O1) and (O3), the construction of a Fukaya-type category would immediately suggest mirror partners for certain classes of examples, the first extension of mirror symmetry to the GC context. During my PhD, I proved foundational results on Lagrangian-type submanifolds with boundary of stable GC manifolds, which naturally arise in examples and are candidates for objects of Fukaya-Seidel-type categories of stable GC manifolds. As an MSC fellow, I would profit from world-leading expertise on symplectic geometry and Fukaya categories at my third-country host institution, while bringing in expertise on the novel research area of generalized geometry. I am looking forward to expanding my own skills in instruction and supervision through a mini course on generalized complex geometry and a Master's thesis project at my EU host KU Leuven.

Keywords: generalized complex geometry,mirror symmetry,symplectic geometry
Endoscopic Comprehensive Optical Multimodal Molecular Intelligent Imaging (ENCOMOLE-2i)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2016-01-01
End date: 2020-12-31
Duration (months): 60.0
Total project cost (EUR): 1998530.0
EU funding (EUR): 1998530.0
Participants: 1
Project status: CLOSED

Optical imaging has exceptional potential for medical diagnosis, because it can provide high spatial resolution and molecular contrast. However, for in vivo imaging in humans, the poor penetration of only a few millimetres is a major obstacle. Optical endoscopes solve this problem, but currently most of them only perform non-advanced, classical white light imaging. Also, the speed of current devices is not sufficient to comprehensively scan entire organs at microscopic resolution. Hence, medical imaging is still dominated by non-optical techniques like X-ray, ultrasound and magnetic resonance imaging. The objective of ENCOMOLE-2i is to push the performance of advanced optical in vivo imaging techniques to cross the application threshold for clinical research and practice. An endoscopic multi-modal molecular imaging platform will be developed with unprecedented capabilities for the diagnosis of disease. The hardware technology development includes three novel imaging modalities. Optical coherence tomography with line rates of several Megahertz will be used for comprehensive structural imaging over large areas. Time encoded stimulated Raman sensing, supported by a new type of two photon microscopy, will be used for guided and referenced molecular imaging. Combining these techniques into one system and interfacing it with a newly developed endoscope will generate great synergy. Moreover, the unique synchronization capabilities of these modalities enable a radically new strategy for more efficient data acquisition: The concept of adaptive “Intelligent Imaging”. The goal is to develop a universal endoscopy platform which can then be specifically tailored to the individual application. In the project the focus is on gastrointestinal imaging. The synergy between technological and algorithmic advances in ENCOMOLE-2i will break ground for more optical in vivo imaging in clinical research and routine, which can finally lead to improved diagnosis of many types of disease.

Keywords: biomedical optics,biomedical imaging,endoscope,optical coherence tomography,raman,fourier domain mode locking,fdml,wavelength tuanble laser
Locked between formulas: creativity in oral and transitional poetic texts (ORFORCREA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-08-01
End date: 2019-09-22
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

The human mind is capable of creativity and innovation unparalleled by any other species. At the same time, human beings elaborate and preserve complex and highly-stable traditions, transmitting them over very long time spans by means of the spoken word and through a variety of technologies, such as writing. How does human cognition give rise to such complex manifestations as oral poetic performance, and how are they affected by the introduction of writing? ORFORCREA investigates the cognitive basis of creativity in verbal art, examining its interplay with both oral tradition and literacy. How can we approach as intricate a problem as verbal creativity with manageable, but at the same time ecologically valid and culturally situated data? While everyday human speech is extremely complex for analysis and has vast lexical and phraseological resources, the language material in oral traditions is typically organized in narrower terms, with idiomaticity enhanced because of poetic requirements, such as the constraints of the poetic line, rhyme patterns, plots, or themes, as well as form-meaning normativity (validity of a given expression within its poetic tradition). The cognitive study of phrasal and grammatical structures in oral poetic traditions is thus comparable to working in a ‘natural’ lab, where the linguistic material, selected throughout long diachronies and innumerable performances, ideally fits the purpose of examining the creative use of formulaic resources. Thus ORFORCREA targets the essential feature of oral poetic traditions, idiomaticity, seeking to produce insights about the formulaic nature of language in general

Keywords: creativity,formulaic language,transitional poetic texts,cognitive poetics