Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
LPMO regulation by (poly)phenolics-active enzymes in Ascomycota (FuelingLPMO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: SIGNED

Lytic polysaccharide monooxygenases (LPMOs) are oxidative enzymes employed by fungi to depolymerize cellulose and thus of great academic and industrial (e.g. biorefinery) interest. The exact way or ways natural electron and H2O2 supply occurs to LPMOs during natural fungal LPMO action (and activation) remains unclear. Recent evidence suggests that LPMOs benefit from two oxidative enzymes (i.e. polyphenol oxidases (PPOs) and laccases) that are active on (poly)phenolic compounds. This gives rise to a new paradigm that places lignin as a protagonist in the activation of cellulose degradation, and not simply an obstacle to biomass decay. FuelingLPMO aims to investigate if and how a novel group of uncharacterized flavoenzymes, which I and other researchers have independenlty reported to be commonly co-secreted with AA9 LPMOs by ascomycetes during lignocellulose degradation, can regulate LPMO activity by modifying lignin-derived compounds, as well as deepen the current understanding on the mechanisms involved in LPMO activation by PPOs and laccases. We will use a combination of genome database mining, proteomics analysis and enzyme synergy characterization to investigate the co-occurence of genes encoding for AA9 LPMOs and these putative LPMO regulatory enzymes among Ascomycota, validate their co-secretion during lignocellulose degradation and test their hypothesized role in the regulation of cellulose degradation by AA9 LPMOs in vitro. The project will form a collaboration between the two research laboratories that made the ground-breaking discoveries of the PPO-mediated and laccase-mediated activation of LPMOs and exploit the multi-/interdisciplinary nature of their studies. Our findings will contribute to a more detailed understanding of the network of redox reactions involved in lignocellulose degradation by ascomycetes, building on the hypothesis that such understanding can be used to design powerful enzyme systems for efficient biomass conversion into bioproducts.

Keywords: lytic polysaccharide monooxygenase,cellulose,lignin,phenolic compounds,flavoenzymes,polyphenol oxidase,laccase,vao family,bbe like,biorefinery,reducing agent,h2o2,genomics,proteomics
MEETings for INnovation Growth in SMEs: Enhancing collaboration with innovative start-ups (MEETING)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Italy,Croatia,France
Call: Peer learning of innovation agencies (H2020-INNOSUP-2018-2019-05, 2019)
Start date: 2020-07-01
End date: 2021-06-30
Duration (months): 12.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

The project wants to identify and design new programmes aimed at supporting the adoption of Open Innovation practices by SMEs, strengthening the collaboration between SMEs and innovative start-ups. In particular, the project will try to understand if and how Open Innovation (OI) tools used with increasing frequency and effectiveness by large companies to get closer to the start-ups world (e.g. collaborations with incubators and accelerators, running of call for ideas, B2B meetings) could be usefully implemented also by SMEs, or if other kinds of initiatives, still to be designed, could be more appropriate for these businesses. The project team will try to identify which role European innovation agencies could play in facilitating the adoption of OI practices by smaller companies. Project partners will be involved in peer-learning activities, using the Twinning+ methodology. Through joint workshops and desk researches, existing programmes consistent with the project challenge will be peer-reviewed. On the basis of good practices and strength points derived from this analysis, project partners will try to identify improvements and new tools, testing their own hypotheses with pilot initiatives whenever possible. The result of the group activities will be a Design Option Paper, a document containing recommendations about the most suitable actions to be implemented by innovation agencies for designing effective SME innovation support programmes. In accordance with the Work Programme, the project aims at strengthening the innovation support capacity of European innovation agencies. Peer-learning activities will help not only the agencies directly involved in Twinning+ in reviewing their service offerings, but also all the subjects interested in promoting the use of OI tools by SMEs. In fact, the DPO will be a useful public guide containing practical suggestions for delivering effective initiatives in this field, addressing all the elements of the Service Delivery System

Keywords: open innovation,innovative start ups,peer learning,innovation agencies,design option paper
Synthesis of PROTAC-Antibody Conjugate for Application in Acute Myeloid Leukemia Therapy (PAC Synthesis)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

The field of immunotherapy has become one of the most promising strategies in fighting cancer. By using the incredible features our very own immune system already possesses, like the powerful tool of specific antibody-antigen recognition, a new generation of drugs can be generated. The idea of linking cytotoxic drugs to monoclonal antibodies with high affinities to specific tumor cells will tremendously improve drug delivery, as tumor-associated antigens can be found by antibodies and the high cytotoxicity of the conjugated drug is used to achieve efficient cancer treatment with less side effects. In this research proposal, we establish a new therapeutic platform that uniquely combines the advantages of two rapidly developing areas – immunotherapy and targeted protein degradation – by developing first class of PROTAC-Antibody Conjugates (PAC). The resulting novel therapeutic agents will help to overcome the limitations arising from lack of cell specificity of PROTACs by exploiting tissue-specificity of the antibody component. Several studies reported encouraging data for the treatment of acute myeloid leukemia (AML) with antibody drug conjugates (ADC) that target the myeloid antigen CD33. In addition, a functionalisable BET inhibitor will be employed in protein degrader construct, generating a new class of small-molecule BET protein degraders. Besides, the proposed self-immolative linker chemistry will allow the traceless realease of the PROTAC once the PAC is internalized into the target cell. Moreover, we will use novel site-selective cysteine bioconjugation approach to build homogenous conjugates that, unlike current examples built using maleimide chemistry, are fully stable in the blood. Overall, this approach will be applicable to any protein of interest and therefore has the potential to advance not only the AML treatment but also the whole field of cancer therapy.
NOCK: Real time safety for our senior relatives. (NOCK)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-09-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

NEKI is a technological company created by seasoned entrepreneurs from different fields like Programming, Marketing and Management. We brought our expertise to this company in order to implement advanced safety solutions for person location and real time communication to relatives or health professionals. Alzheimer and other cognitive impairments are a key concern in a global scope, causing dis-orientation among our senior relatives and discomfort among people in charge of their wellness. Elderly people find difficulties in their daily activities and get lost without being able to find their way home or even telling other people where their address is. The risk of getting lost is real and one single night outdoors can be lethal to them. 146,042 people disappeared in Spain along last 20 years, and 6,053 have not yet been found, being most of them seniors or suffering cognitive impairment. Most advanced societies show similar seriousness figures. NOCK Project is the evolution of NEKI technology for a comfortable adaptation to senior people, who are provided with GPS location and communication systems, so they are constantly tracked by their relatives and caregivers. The system is composed of different technological pieces developed by NEKI along last 3 years and has already a great rate of paying customers and visibility, as we will describe along this document. Nowadays, closing an initial €130,000 investor round and achieving €60,000 from a public institution loan will lead us to our actual market deployment in European and Global scopes. The Project already counts on powerful stakeholders at technological and health & care sector levels, what has provided us not only with visibility but also with actual revenues. These stakeholders, together with gathered experience have led us to current tested service performance, great recurrent revenues and Project planning, which we will need to test along next months for achieving an international market deployment as succes

Keywords: alzheimer,neurology,seniors,quality of life
G-Quadruplex-associated proteins (QAPs) and their role in transcriptional regulation (QAPs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

In the human genome, many G-rich sequences have the potential to form 4-stranded non-canonical secondary structures known as G-quadruplexes (G4s). G4 structures have been visualized in nuclei by immunofluorescence and mapped genome-wide to regulatory chromatin regions linked to elevated transcription using G4 chromatin immunoprecipitation and high-throughput sequencing (G4 ChIP-seq). G4s are implicated in gene regulation, DNA replication and genome instability, yet little is known about their protein interaction partners or role in regulating genome activity. We therefore propose to develop G4 Rapid Immunoprecipitation Mass Spectrometry of Endogenous Proteins (G4 RIME) methodologies to elucidate the G4 interactome within a native chromatin context. ChIP-seq of protein candidates coupled with G4 ChIP-seq will verify binding at endogenous G4 structures. Using established biophysical and biochemical techniques, we will investigate binding modes, recruitment and effects on G4 dynamics. Consecutive chromatin immunoprecipitation steps using antibodies targeting characteristic chromatin marks as well as G4 ChIP-seq supported by bioinformatics analysis of genomic databases will identify proteins involved in transcriptional regulation. We will then test the consequence of stabilising G4s with small molecule ligands on the G4 interactome and how this is modulated during genomic stress. Cells genetically deficient in G4-interacting proteins will enable detailed exploration of G4 formation and transcriptional effects. This highly interdisciplinary project will provide a wide range of excellent training opportunities exploiting the Balasubramanian group’s unique position with laboratories at the Cancer Research UK Cambridge Institute (CRUK CI) and the Department of Chemistry. Overall, the studies will generate novel functional insights in the G4 biology that may ultimately lead to the identification of mechanisms and pathways for new anti-cancer agents.

Keywords: g quadruplexes,chemical biology,proteomics,functional genomics,dna protein interaction,chromatin,transcription,transcriptional regulation,genome stability
Certified smart and integrated living environments for ageing well (Homes4Life)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Coordination and support actions
Countries involved: Italy,Spain,Belgium,France,France,Netherlands,Netherlands
Call: Supporting investment in smart living environments for ageing well through certification (H2020-SC1-DTH-2018-1, 2018)
Start date: 2018-12-01
End date: 2021-02-28
Duration (months): 27.0
Total project cost (EUR): 999706.25
EU funding (EUR): 999706.25
Participants: 9
Project status: CLOSED

Age-friendly environments are one of the most effective approaches for responding to demographic ageing and increasing the Healthy Life Year indicator. However, there is still a huge building stock not adapted to the needs of older people. Even today, new buildings don´t yet properly address the need for creating smart living environments for ageing well. Homes4Life addresses this challenge by contributing to the development of a common European framework for age friendly living environments, and defining the Homes4Life certification scheme to tackle end-users’ needs and requirements through a holistic and life-course approach integrating Construction and ICT solutions. The different socio-economic conditions (housing ownership, family structure, health system, etc) and building typologies among the EU member states will be analyzed in detail to provide the necessary flexibility to map the Homes4Life certification scheme to the specificities of each country with a user-centric approach. The scope of Homes4Life scheme will cover both new and existing buildings. The strategy to define the certification scheme will be: i) analyzing the main difficulties and needs faced by older people to age at home, ii) identifying the physical and digital solutions that increase their quality of life and wellbeing, iii) assessing the availability, functionality and quality of service of the existing solutions on a specific home. Homes4Life scheme aims to foster (public and private) investment making explicit the benefits for each stakeholder of transforming the building stock into a smart and integrated age friendly living environment. Considering the need for social consensus for the development of this certification scheme the consortium will be supported by an expert board that includes 14 key players in aging at home domain, covering complementary disciplines (investment, standardization, e-health, building and design, public social services) and a Stakeholders Community.

Keywords: certification,living environment for ageing well,smart home
Return mobilities to rural Portugal: an assessment of the production of place (MigRural)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Portugal
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2021-02-16
Duration (months): 24.0
Total project cost (EUR): 160635.6
EU funding (EUR): 160635.6
Participants: 1
Project status: CLOSED

Although emigration of Portuguese gains importance in the public opinion and political discourses, as shown by press releases and political declarations the past years, within the Portuguese academic context, emigration and return have been marginal objects of study. This project addresses one of the mobility patterns affecting Portugal: the return of Portuguese immigrants who reside or resided in France to rural regions of the country. Within this context, it aims at critically examining the economic, social and political impacts of return mobilities in rural decayed areas, and comparing the current situation to works produced in Portugal in the 1980s and early 1990s. It also interrogates the role of this immigration within a wider range of mobilities that affect rural localities. More generally, MigRural participates in the better understanding of return mobilities on the one hand; and rural localities on the other hand; as well as the intersection between immigration and production of places. It can therefore offer rich insights on the inclusion of returnees and their participation in the revitalisation of rural former ‘exodus’ areas. In fact, return migration can be seen as a “force for change in rural society” (Black, 1993).

Keywords: return migration,return mobilities,rural,periphery,place,home making,homing,immigrant integration,local policy
Brain-based Evaluation of Autism Phenotypes Using Longitudinal, Multimodal Imaging Data (BEAUTIPHUL MIND)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-09-01
End date: 2023-10-01
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

Methodological developments have equipped scientists with unprecedented opportunities to characterize brain structure and functional organization and relate it to behaviour. Yet to date, no clinically relevant tools, grounded in this neurobiology, have been developed that inform clinical outcomes in psychiatric disorders. Specifically, in autism – one of the most common neurodevelopmental conditions – there is still little knowledge about the neurobiological underpinnings of different clinical outcomes with regard to core symptoms and adaptive daily living skills. While some individuals worsen, others do better over time. Like in many realms of medicine where biomarkers have revolutionized treatment, there is also an urgent need to develop such neurobiologically-grounded predictors for clinical outcomes in autism. To date, the majority of studies have analysed small, cross-sectional samples across single neuroimaging modalities with case-control comparisons to find mean group effects. However, this standard approach ignores the large sample variation in autism. The overarching objective of my MSCA Fellowship is to establish a multimodal, longitudinal characterization of the individual neurobiological signatures that are predictive of clinical outcomes in autism. I will integrate both structural and functional neuroimaging modalities for a fine-grained characterization of the neural phenotypes in autism. Using normative modelling, I will characterize at the level of the individual (rather than with group averages) how each individual with autism is different from the neurotypical pattern of such a multimodal brain characterization and how it relates to behaviour, genetic risk and clinical outcome. This novel approach has the potential to transform clinical management in autism, leading to the development of neuroscientifically-informed, targeted interventions. I will also provide the research community with novel tools that pave the way for precision medicine.

Keywords: autism spectrum disorder,neuroimaging,structural and functional magnetic resonance imaging,normative modelling
Simulation of Transport between the Adriatic Sea and the Danube (STRADA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-08-01
End date: 2026-07-31
Duration (months): 60.0
Total project cost (EUR): 1923805.0
EU funding (EUR): 1923805.0
Participants: 1
Project status: SIGNED

Even though transport had a bad reputation in the discourse of the Roman elites, in recent research it became evident, that it had a vital impact on the prosperity of the Roman economy and thus on the long-term existence of the Roman Empire. Therefore, it is an absolute desideratum to explore Roman inland transport transdisciplinary, combining recent technological developments with experimental data and profound historical research to gain the most realistic transport times. The objective of STRADA is the development of a dynamic computer-based simulation system for water and land borne transport between the Adriatic Sea and the Danube. Thereby, STRADA is geared to three aims: a) the study of the spatial and temporal interconnectivity between Roman Italy and the Danube frontier, for gaining a better understanding of the economic cohesion of the Roman Empire, b) the analysis of the influence of environmental factors on the ancient transport system, c) and the introduction of dynamic simulations into historical research. For the implementation, the project will focus on three closely interwoven strands: The exact reconstruction of the ancient land- and water-routes, the experimental determination of the performance of the used land- and water-borne means of transport under changing environmental conditions, and the development of a time-related simulation system including local fine granular topography and historical weather data, different means of transport (water- and land-based) with different loads, the fatigue of the actors as well as necessary rests and loading times. STRADA will follow a modular design that will ease the sustainable use and a future extension of the simulation system. The chosen research area covers a wide range of landscapes from the Mediterranean lowlands, followed by different kinds of alpine regions, to a central European river landscape, which makes it easy adapt¬able to other times and places.

Keywords: dynamic simulation,ancient transport,roman empire