Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Solar Thermal Cogeneration Plant based on Organic Rankin Cycle (EFISOL)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: Croatia,United Kingdom,Spain,United Kingdom,Italy,Bulgaria,Croatia
Call:  (FP7-SME-2008-1, 2008)
Start date: 2009-07-01
End date: 2011-06-30
Duration (months): 24.0
Total project cost (EUR): 1521716.2
EU funding (EUR): 1134823.0
Participants: 10
Project status: CLOSED

Strategic overall objective of the proposed project is to develop an efficient and cost effective small solar energy system for combined electrical energy power and hot water production that uses concentrated direct solar radiation as the primary energy source. In order to achieve these objectives we are presenting a concept that is based on the highly innovative integration of existing technologies, development of new thermo energetic components and advance guidance and control system implementation. All components will be integrated and optimized as an autonomous unmanned power production unit in a form of new commercial product, the EFISOL. EFISOL is therefore a combination of following key innovative technologies; - half linear Fresnel lens based concentrators - PCM (phase change materials) based heat storage tanks - ORC (Organic Rankin Cycle) cogeneration unit - Advanced control system This proposed system will be suitable for various small and medium energy consumers, it will be particularly well suited to those placed in ‘sunny areas’ such as MEDITERRANEAN AREA. Various types of energy consumers e.g. hotel resorts, campsites, industrial units, housing groups and energy producer entrepreneurs are targeted users. Proposed product will be able to produce renewable electrical energy and sell it directly to the power grids or use it for internal consumption purposes. This proposal will emphasize the most relevant issues to be addressed by this project. EC is investing large sums of money in Renewable Energy sources in order to increase the overall efficiency of technology, improve their cost benefit effects and finally gradually reduce incentives on renewables. To answer on that we are proposing development of a product that will still remain profitable even with lower el. energy incentives.

Keywords: phase change materials,fresnel concentrator,light weight polimers
A SEMANTIC SERVICE-ORIENTED PRIVATE ADAPTATION LAYER ENABLING THE NEXT GENERATION, INTEROPERABLE AND EASY-TO-INTEGRATE SOFTWARE PRODUCTS OF EUROPEAN SOFTWARE SMES (EMPOWER)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: Romania,Norway,Greece,Türkiye,Cyprus,Hungary
Call:  (FP7-SME-2008-1, 2008)
Start date: 2009-05-01
End date: 2013-02-28
Duration (months): 46.0
Total project cost (EUR): 1507742.42
EU funding (EUR): 1123155.0
Participants: 9
Project status: CLOSED

The 24-month EMPOWER project proposes an innovative framework and the enabling technologies that will allow the European Software SMEs to create their next generation, loosely-coupled, interoperable and easy-to-integrate Commercial-off-the-Shelf software products, leveraging the quality of the application software and the integration services delivered to their customers. The EMPOWER project will, finally, result in: R1 & R2: An innovative EMPOWER Reference Framework and Adaptation Environment that enables the European Software SMEs to ad-hoc define and extract pieces of functionality from their legacy systems, implementing a semantic service-oriented private adaptation layer upon each of their software products. R3: the EMPOWER Ontology that constitutes the corner stone of the semantic adaptation of the enterprise services exposed from given proprietary software products; R4: the Enterprise Interoperable Services Semantic Map that constitutes the semantically-enriched, abstract documentation of the interoperable pieces of functionality defined per each type of business software applications; R5: five (5) EMPOWER SMEs-specific Prototypes that will validate and prove the concepts and software components and tools of the proposed EMPOWER project; R6: the EMPOWER Adoption Guidelines that will constitute a semantic service-oriented analysis and adaptation cookbook for the development of the next generation, interoperable and easy-to-integrate software products; and R7: wide-scale dissemination and exploitation of the project results to the European Software SMEs market (with special focus on the emerging enlarge-Europe software industry). Led by LOGO, the consortium consists of eight partners from six EC member states and associated countries, including software development SMEs, industrial companies and research centres.

Keywords: interoperability,legacy systems,software smes
Central Design Team (CDT) for a Fast-spectrum Transmutation Experimental Facility (CDT)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Radioactive waste management
Destination: Management of Ultimate Radioactive Waste
Action type: Collaborative project
Countries involved: Belgium,Germany,Italy,Italy,Spain,France,France,Spain,United Kingdom,Germany,Portugal,Netherlands,Spain,Italy,Japan,Korea, Republic of
Call:  (FP7-Fission-2008, 2008)
Start date: 2009-04-01
End date: 2012-09-30
Duration (months): 42.0
Total project cost (EUR): 4029789.0
EU funding (EUR): 2000000.0
Participants: 20
Project status: CLOSED

Besides the European Global Energy Policy, the European Council adopted an action plan that covers nuclear technologies and supports research in order to "further improve nuclear safety and the management of radioactive waste". To obtain a more efficient and sustainable management of radioactive waste and hence reduce the burden on geological storage, one can apply partitioning and transmutation independently of future commitment or not to nuclear energy. Within European Union many R&D organisations and industries are conducting since a decade strong R&D in the Partitioning &Transmutation (P&T) field with substantial support from the European Commission. Fostering the European efforts towards a major facility realisation would be very beneficial. This will speed up the development and put Europe at lead in this field. The design of a fast spectrum transmutation experimental facility (FASTEF), able to demonstrate efficient transmutation and associated technology through a system working in subcritical mode (ADS) and/or critical mode, is thus the next step after FP6 IP-EUROTRANS. In the vision report of the "Sustainable Nuclear Energy Technological Platform", the need was clearly expressed for a fast-spectrum experimental system to support the development and demonstration of an alternative technology to sodium. Therefore, FASTEF is proposed to be designed to an advanced level for decision to embark for its construction at the horizon of 2012 with the following objectives: to demonstrate the ADS technology and the efficient transmutation of high level waste; to operate as a flexible irradiation facility; to contribute to the demonstration of the Lead Fast Reactor technology without jeopardising the above objectives. The work programme is subdivided in 5 WP's: WP0: Management of the Project WP1: Definition of specifications and detailed work programme of FASTEF WP2: Design of the FASTEF in sub-critical & critical mode WP3: Plant Requirements WP4: Key issues towards realisation

Keywords: partitioning and transmutation,fast-spectrum experimental facility,central design team
Development of a new, non invasive absolute Intracranial Pressure (aICP) measurement device based on ultrasound and Doppler technologies (BRAINSAFE)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: Germany,France,Lithuania,Spain,Spain,United Kingdom,Denmark,Lithuania
Call:  (FP7-SME-2008-1, 2008)
Start date: 2009-10-01
End date: 2011-09-30
Duration (months): 24.0
Total project cost (EUR): 1188525.46
EU funding (EUR): 895517.0
Participants: 9
Project status: CLOSED

Only invasive technologies only for diagnostics of Intracranial Pressure (ICP) for patients with severe Traumatic Brain Injury (TBI) are available today. The procedure requires neurosurgeon to place the catheter inside the patient´s skull that exposes the patients to the risk of infection (5%), bleeding, leak of fluids or loss of other body tissue, pain, hyperthermia as well as risks related to anaesthetics. Relative to these risks and complexity of the procedure, only 20% of all TBI patients get access to the diagnostics of ICP, leaving out 1,280,000 TBI patients without proper examination of their brain injuries in Europe yearly. The lack of early diagnosis of increased ICP causes 100,000 new long-term disabilities and 400,000 deaths each year for these patients. Early diagnosis of mild and moderate TBI also requires non-invasive ICP measurement. The BrainSafe project offers an innovative technology for non-invasive and fast-and-easy absolute intracranial pressure (aICP) diagnostics that can save 9,400 lives and increase the chance of survival and life span for additional 136,000 patients with TBI yearly. The innovative aICP measurement device will completely eliminate all the risks associated with invasive methods of ICP diagnostics. Overall project objectives are: 1. To develop a technology, based on Ultrasonic Transcranial Doppler system, for non-invasive aICP meter with a measurement accuracy of +/-2 mmHg 2. To develop the technological requirements for a hand held aICP meter for easy access and simple use, without acquiring intensive training of health care personnel The BrainSafe project is initiated by the SME Vittamed who has background knowledge and holds all IPR of the proposed technological concept. It is carried out by a consortium of field experts within ultrasonic techniques, signal processing and ergonomic hardware design to ensure full comfort to the patients and medical personnel.

Keywords: ultrasound,tcd
Development of innovative biodegradable packaging system to improve shelf life, quality and safety of high-value sensitive horticultural fresh produce (HORTIBIOPACK)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: Greece,France,Italy,Italy,Sweden,Italy,Sweden
Call:  (FP7-SME-2008-1, 2008)
Start date: 2009-11-01
End date: 2012-04-30
Duration (months): 30.0
Total project cost (EUR): 1510276.0
EU funding (EUR): 1131807.0
Participants: 10
Project status: CLOSED

Modified atmosphere packaging (MAP) is increasingly used with minimally processed fresh produce. Equilibrium Modified Atmosphere Packaging (EMAP) of Fresh Produce is also increasingly used to extend shelf-life of fresh produce. Increased MAP and EMAP usage coupled with negative environmental views associated with nondegradable synthetic packaging materials creates a societal and SMEs need for biodegradable films. Several research efforts have been carried out and work is in progress aimed at developing biodegradable packaging materials for various applications, including food packaging. A limited portion of this research effort is dedicated to MAP packaging systems. The development of biodegradable films that are based on renewable raw materials and designed for EMAP systems for fresh produce, meeting the design criteria of water vapour and gas barrier properties, ensuring safety of the produce while maintaining the original quality, firmness and colour of the fresh produce is still at the very early stages of research and development. The proposed project aims at developing innovative and safe biodegradable Equilibrium Modified Atmosphere Packaging film systems based mainly on the use of environmental friendly biodegradable raw materials and aimed at the improvement of the shelf life, quality and safety of specific high value sensitive horticultural fresh produce.

Keywords: emap,fresh fruit packaging,packaging films,biodegradable plastic films
The PharMEA Platform: Multi-Electrode Array technology based platform for industrial pharmacology and toxicology drug screening (PHARMEA)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: France,France,Switzerland,United Kingdom
Call:  (FP7-SME-2008-1, 2008)
Start date: 2009-09-01
End date: 2011-11-30
Duration (months): 27.0
Total project cost (EUR): 1885200.0
EU funding (EUR): 1452000.0
Participants: 7
Project status: CLOSED

The project PharMEA is based on the technology platform of multi-electrode arrays, which have been widely used for electrophysiological experiments on neuronal and cardiac tissues. Some of the key advantages of MEA technology include ease of use, non-invasive measurements and simultaneous multi-site recording & stimulation capability. Despite these key advantages, MEA technology utilization has remained largely confined in academic research institutions, primarily due to the low throughput of currently available MEA-based tools. The PharMEA project addresses these shortcomings by developing novel MEA tools and applications that will significantly increase throughput of MEA experiments, facilitate MEA experiments on various culture models, as well as associated applications tailored for the drug discovery industry. Specifically, the new MEA tools will increase the number of channels or measurement sites for simultaneous recording and stimulation from about 120 channels today to 1024 channels, along with the corresponding intelligent data handling and processing strategies. Furthermore, the PharMEA project will develop and automate biological assay protocols that are common in ion-channel based drug discovery activities, as we this will add significant value to and bring out the benefit of the proposed tools. Altogether, the results of this project will accelerate the uptake of MEA tools in the drug discovery industry, thereby significantly increasing the market opportunity and competitive edge of the various sponsoring SMEs in the lucrative drug discovery industry.

Keywords: electrophysiology,high density multi-electrode arrays,data acquisition,real time data processing and analysis
Epigenome and Cancer Susceptibility (EPISUSCEPTIBILITY)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Diagnostic tools, therapies and public health
Countries involved: Finland
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-04-01
End date: 2014-09-30
Duration (months): 66.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

Early detection is crucial for the outcome of most cancers. Prevention of cancer development is even more desirable. To facilitate these ultimate goals we aim to construct a comprehensive view of the stepwise process through which common human cancers, such as colorectal cancer, arise. In particular, we aim to identify novel mechanisms of cancer susceptibility by focusing on the epigenome, whose alterations may underlie several phenomena related to chronic adult-onset disease that are not explained by genetics alone. The stepwise process of carcinogenesis can be accelerated or halted for various reasons, including inherited susceptibility and diet. The human multi-organ cancer syndromes hereditary nonpolyposis colorectal cancer (HNPCC) and familial adenomatous polyposis (FAP) as well as their murine counterparts, the Mlh1+/- mouse and the ApcMin/+ mouse, will be used as shortcuts to study the interplay between the epigenome and genome in tumorigenesis and to identify biomarkers of cancer susceptibility, malignant transformation, and tumor progression. This will be achieved by molecular profiling of normal and tumor tissues, cell line studies, in vitro functional assays, and in silico approaches. Additionally, the role that the epigenome plays to mediate the effects of the Western type diet on colorectal tumorigenesis will be examined in the mouse. Unlike genetic changes, epigenetic alterations are potentially reversible, which makes them promising targets for preventive and therapeutic interventions.

Keywords: hereditary cancer,cancer prevention,genomic instability,dna methylation,diet,mouse model,tumorigenesis
From Neuron to Behavior (NEURO-BEHAVIOR)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: Germany
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-02-01
End date: 2014-01-31
Duration (months): 60.0
Total project cost (EUR): 2499600.0
EU funding (EUR): 2499600.0
Participants: 1
Project status: CLOSED

In the present proposal I will describe a novel research agenda for understanding the neural basis of mammalian behavior. Three central problems prevent current research from explaining mammalian behavior in terms of neural mechanisms. First, there is a preponderance of correlative evidence in systems neuroscience. Second there is generally insufficient information about the individual neuron(s) under study. Third, there is a lack of integration of information. Current neuroscience is characterized by strongly diverging research interests and this highly divergent and specialized research program cannot lead to systemic understanding of brain function. We will confront these problems by three novel research approaches: (1) We will establish a causal link between cellular activity and behavior by a single-cell-stimulation / reverse physiology approach. (2) We will obtain rich information about single neurons by whole-cell recordings in awake behaving animals. (3) We will perform a whole-brain-analysis of a novel model organism, the Etruscan shrew, in which we will record the activity of all neurons in the shrew s brain. The research proposed here is unique, because as no other research group investigates brain function by a single-cell-stimulation, by intracellular recordings in freely moving animals, or by whole-brain analysis. The research outlined here will probe the relationship of neural activity and behavior in an entirely unprecedented fashion.

Keywords: reverse physiology,whole-brain-analysis
Design of optimised systems for monitoring of radiation and radioactivity in case of a nuclear or radiological emergency in Europe (DETECT)

Framework: FP7 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Radiation protection
Destination: Radiation Protection
Action type: Collaborative project
Countries involved: Belgium,Germany,Germany,Germany,Denmark,Norway
Call:  (FP7-Fission-2008, 2008)
Start date: 2009-07-01
End date: 2011-12-31
Duration (months): 30.0
Total project cost (EUR): 712932.0
EU funding (EUR): 400000.0
Participants: 6
Project status: CLOSED

The Call for this project proposal describes the objective as “to develop a methodology for optimising the design of monitoring systems for timely and effective decision making in an emergency”. This objective together with the expected impact (“A tool for making more efficient use of monitoring resources and improving the bases for decision making in emergencies, in particular in the context of the need to upgrade/replace during the next decade many of the monitoring systems installed post-Chernobyl”) can be seen so that the project shall provide all relevant information needed in design of monitoring strategies and show how this information can be used in planning of monitoring systems in an optimised way.

Keywords: radiation monitoring,nuclear emergency response,monitoring,radioactivity
Identification of a new mechanism of stem cell self-renewal; direct implications on self-repair and tumor initiating cells in the brain (STEMRENEWAL)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Advanced grants
Action type: Support for frontier research (ERC)
Panel: Neurosciences and neural disorders
Countries involved: Sweden
Call:  (ERC-2008-AdG, 2008)
Start date: 2009-03-01
End date: 2014-02-28
Duration (months): 60.0
Total project cost (EUR): 2492593.0
EU funding (EUR): 2492593.0
Participants: 1
Project status: CLOSED

The self-renewing nature of stem cells is a consequence of their ability to proliferate indefinitely while maintaining pluripotency. Mechanisms of pluripotency are well known but mechanisms controlling stem cell proliferation are unknown. Proliferation of somatic cells takes place in G1 cell cycle phase. We have identified that embryonic and peripheral neural stem cell proliferation is regulated by an entirely new mechanism involving chromatin remodeling and operating in the S/G2 phase of the cell cycle (Andang et al., Nature 2009). This involves the DNA damage response (DDR) pathway proteins. The DDR pathway is activated physiologically by GABA acting by the GABAA receptor leading to Cl- influx, cell swelling, and by unknown mechanism, activation of the PI3K related kinases ATR/ATM which phosphorylates histone H2AX. Combined, the data suggests that the DDR pathway is operating in a ligand-dependent manner under normal physiological conditions and that it may serve as a new molecular mechanism regulating cell proliferation in eukaryotic cells. We propose a homeostatic mechanism of stem cell proliferation where negative feedback control of the cell cycle adjusts stem cell numbers. The demonstration of normal, physiological, ligand-induced activation of these pathways in stem cell niches opens fundamentally new insight into the mechanisms of stem cell proliferation and surveillance against cancer. Once characterized, we propose that these mechanisms may be exploited to induce self repair following brain damage and to manipulate cell survival in tumor initiating cells of the brain (that share many characteristics with stem cells). The potential benefit of this proposed research could be vast, involving potentially a unifying mechanism how all stem cell niches in the embryo and in the adult individual is regulated and can be manipulated.

Keywords: neurogenesis,development,adult subventricular zone,neural stem cells