Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Self-DRiving hydrOPonic System - Develop automated hydroponic systems that use high frequency pulsing-light and intermittent/alternate nutrient supply to optimize resources and plant adaptation. (SunDROPS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Today, reducing energy consumption and utilization of natural resources whilst maintaining high productivity is a necessary step to accomplish both sustainable agricultural and the supply of an increasingly worldwide food demand. For these reasons, improving precision and automation in horticulture farming are the main future challenges. In this context, the project focuses on the development of an automated hydroponic cultivation system driven by the plant “itself” able to optimize the request of light, water and nutrients. The aim is to develop an automated system able to detect the needs of the plants by the interpretation of the electrical signals generated by the plants under specific stresses. For these purpose the project main objectives are to: • Develop a self-driven dynamic and manageable hydroponic system able to modify the flow and the nutrients compositions supply by monitoring the plant status. • Study and optimise light quality and quantity demand by using pulse width modulated-high brightness-light emitting diodes lights (PWM-HB-LEDs) capable of pulsing at high frequency, to investigate the different light spectra required and the optimum values of frequency/duty in the cycle of the flashes. By performing these tasks the project is expected to: i) develop an auto-piloted hydroponic set-up able to interpret and process the plant electrical signals for a crop growing system based on plant’s need, thus able to avoid water and nutrients waste; ii) give new insights on mechanisms influenced by intermittent/alternate nutrient supply using a Flood-Drain-Flow (FDF) hydroponic system to improve adaptation, increase salt stress resistance or modulate plant features; iii) determine the optimal pulsing RGB-light regime supply (in terms of frequency and duty) to reduce energy consumption whilst optimizing plant growth and modulating specific plant traits; iv) build a flexible and modular hydroponic set-up to be scaled-up for automated plant factories.

Keywords: hydroponic system,plant electrical activity,leds,light,plant tolerance,salt stress,drought stress,volatile organic compounds,hydroponic nutrients,automated cultivation,plant growth
Amenability, Approximation and Reconstruction (AMAREC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-10-01
End date: 2024-09-30
Duration (months): 60.0
Total project cost (EUR): 1596017.0
EU funding (EUR): 1596017.0
Participants: 1
Project status: SIGNED

Algebras of operators on Hilbert spaces were originally introduced as the right framework for the mathematical description of quantum mechanics. In modern mathematics the scope has much broadened due to the highly versatile nature of operator algebras. They are particularly useful in the analysis of groups and their actions. Amenability is a finiteness property which occurs in many different contexts and which can be characterised in many different ways. We will analyse amenability in terms of approximation properties, in the frameworks of abstract C*-algebras, of topological dynamical systems, and of discrete groups. Such approximation properties will serve as bridging devices between these setups, and they will be used to systematically recover geometric information about the underlying structures. When passing from groups, and more generally from dynamical systems, to operator algebras, one loses information, but one gains new tools to isolate and analyse pertinent properties of the underlying structure. We will mostly be interested in the topological setting, and in the associated C*-algebras. Amenability of groups or of dynamical systems then translates into the completely positive approximation property. Systems of completely positive approximations store all the essential data about a C*-algebra, and sometimes one can arrange the systems so that one can directly read of such information. For transformation group C*-algebras, one can achieve this by using approximation properties of the underlying dynamics. To some extent one can even go back, and extract dynamical approximation properties from completely positive approximations of the C*-algebra. This interplay between approximation properties in topological dynamics and in noncommutative topology carries a surprisingly rich structure. It connects directly to the heart of the classification problem for nuclear C*-algebras on the one hand, and to central open questions on amenable dynamics on the other.

Keywords: amenable group,c algebra
Early childhood education eLearning framework, leveraging novel technology for a whole new way of learning music. (Pomelody 2.0)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Poland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-03-01
End date: 2018-07-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Scientific research proves that early music education, specifically by children ages 0 to 5, is a powerful tool for attaining children’s full intellectual, social and creative potential. Numerous research studies show indisputable evidence that learning music at an early age speeds the development of speech and reading skills, leading to improved comprehension. Musically trained children develop to their full potential, in contrast to the outdated, normative learning models. The early childhood educational paradigm has not experienced changes in decades. Current model is qualitative, teacher-centred and universal. On top of that, formal early childhood education suffers many challenges, including budget cuts, very low attendance in ECE by children and inadequate music qualifications of early childhood educators. Today, professional early childhood music education is purchased by parents in the form of private music classes, or one-off music performances. The burden is on the parents to take up private tuition, and the high costs of private, stationary lessons is a major barrier. Pomelody is the world’s first and only, eLearning framework for comprehensive music education for infants, toddlers and pre-schoolers, which we describe as analogous to a combination of Netflix and Spotify. Pomelody combines our eLearning web application, with assisted learning software tools to track, analyse and enhance children’s learning processes, increasing learning impact and the final performance. Pomelody is a direct response to the “gap” between research and practice on early childhood music education, and fills a significant market gap within the edTech and eLearning segments. Pomelody partakes in the rise of a next giant market opportunity, where according to forecast the global eLearning market for kids is poised to grow over the next decade to reach $325 billion by 2025.

Keywords: elearning,music education,early childhood education
Advanced Innovation Support Services for SMEs (AISS4SME)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Luxembourg
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 37192.5
EU funding (EUR): 37192.0
Participants: 3
Project status: CLOSED

The AISS4SME project aims at offering new services to enhance the innovation management capacities of luxembourg SMEs. 2 target group of SMEs will be address : first, the beneficiaries of the SME instrument and, second, innovative SMEs. This proposal is a response to the Consultation of Enterprise Europe Network partners on the work programme for 2019 H-2020 activities H2020-EEN-SGA3-2019 “Enhancing the innovation management capacity of SMEs” in the Enterprise Europe Network”, and concerns the set up of coaching and mentoring services for SMEs. It’s our confidence that the AISS4SME proposal is 100% in line with the challenge and scope defined by the EC. Moreover, by pursuing the defined strategic objectives, the project will automatically produce the expected overall impact of: • Enhancing the commercial potential and impact of SME participation in the dedicated Horizon 2020 instrument by ensuring that the project is aligned with and developed as an integral part of the company's innovation strategy, • Achieving tangible organizational change and improved results, • Improving the skill's levels of managers, leaving a legacy such that the SME is better able to overcome the barriers to growth post-Horizon 2020 participation.

Keywords: innovation,advisory,key account management,h2020,fast track to innovation,future emerging technologies,innovation management capacity
Deacetylase inhibitors for autism spectrum disorders: an integrated preclinical validation pipeline in brain organoids and in vivo models (DUPDOWN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-07-01
End date: 2022-12-31
Duration (months): 30.0
Total project cost (EUR): 167852.14
EU funding (EUR): 108345.0
Participants: 2
Project status: CLOSED

ASD is a very prevalent neurodevelopmental condition affecting more than 1% individuals, and represents a major unmet medical need since no effective treatment is available. Despite the phenotypic convergence of its core symptoms (impaired language, restriction in sociability and stereotypies, invariably coupled to anxiety and often associated to varying degrees of intellectual disability), ASD is genetically highly heterogeneous, with hundreds of bona fide causative genetic lesions. This genetic architecture breaks down ASD into a collection of rare and highly penetrant genetic syndromes, presenting key challenges but also decisive applicative opportunities: i) the accelerated regulatory path for drug approval/repurposing; and ii) the possibility that few paradigmatic syndromes may yield generalizable therapeutic inroads for ASD treatment. Duplication at 7q11.23 (7Dup), encompassing 26-28 genes, is one of best characterized ASD-causing copy number variations and offers unique translational opportunities, also because hemydeletion of the same interval causes Williams-Beuren syndrome, a condition characterized by hypersociability and language strengths, thereby providing a unique reference standard to validate treatments for the core ASD symptoms. Within my ERC-Consolidator project we successfully completed a high-throughput screening on 7q11.23 CNV patient-derived neurons and discovered that deacetylase inhibition lowers the abnormal levels of a key gene underlying the cognitive/behavioral traits of 7Dup. Having defined robust 7Dup neurodevelopmental and electrophysiological phenotypes, both in patients’ neuronal lineages and in mouse models, we now aim to generate proof of concept for the preclinical validation of selected deacetylase inhibitors in rescuing ASD phenotypes in vitro and in vivo. For this we pursue an integrated experimental and business plan, buttressed by key industrial partnerships, to advance the most inhibitors towards ASD treatment.

Keywords: autism spectrum disorder asd,sociability,preclinical validation,hdac inhibitors,induced pluripotent stem cells ipsc,brain organoids,gtf2i
3D Sound Navigator Assistant for Visually Impaired People (NAV4VIP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Spain
Call: SME Instrument (H2020-SMEINST-1-2015, 2015)
Start date: 2015-06-01
End date: 2015-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Ensuring that a visual impaired people can walk safely along a given path in a hazardous environment is a dedicated and slow task demanding continuous assistance from other people. Many technical developments and research have already implemented autonomous mobility solutions for visual impaired people. However, a solution providing virtual lead-line including track perception and safety guidance is not available in the market. NAV4VIP is the first device that integrates Galileo-based navigation and 3D acoustic reality to improve autonomy and safety of visual impairment people. It implements a new and innovative eyes/hands/mind-free 3D Sound Navigator Assistant providing a personal guidance system that allows autonomous and safety movement along predefined paths. The instrument provides route perception based on the combination and deep integration of accurate GNSS positioning, including high-precession Galileo signals, and 3D Augmented Acoustic Reality based on binaural technology sounds audio. The state of the solution and technology developed is classified as TRL-7. Prototype demonstration in operational environment has been successfully accomplished with two previous research projects (ARGUS in FP7-EC and ACOUSTIC TRAIL in MINETUR-Spain). NAV4VIP concept has been awarded with the GSA Special Topic Prize in the 2012 European Satellite Navigation Competition Galileo Masters. Patent process has already started The SME instrument project will decisively impact on the company growth and evolution enabling the international commercialisation of NAV4VIP. With a market of 1.9% of the global population, the company expects to double turnover during the first year of commercialisation, keeping linear growing during next years. The SME instrument Phase 1 will produce a consolidated business plan, enabling a Phase 2 to support the required investment and to increase company staff up to 15 employees. Estimated ROI is greater than 25% during the product life.

Keywords: gnss,galileo,egnos,binaural,blind,visual,impairement
Functionalized AuNPs and their use for biological applications (AuNP-PhotoBioDrug)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-13
End date: 2017-05-12
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The development of gold nanostructures is a topic of high interest due to their extensive use in biomedical applications, biosensing and bioimaging because of their specific properties: high stability, ease of detection, facile synthesis and functionalization, etc. It would be of potential interest to predict the photobehaviour of AuNPs before introducing them in a biological environment. In this respect, when NPs interact in a living milieu, proteins will adsorb onto its surface generating a protein corona; this may provoke changes in the biological function of the protein and in the photophysical properties of the AuNP; thus, the photophysical behaviour of AuNPs in solution cannot be directly extrapolated to the biological media. These effects have been barely investigated up to now. The design of new gold nanoparticles whose photophysical behaviour can be extrapolated in a greater degree to a biological environment is of potential interest for in vivo applications due to the fact that their photobehaviour would be predictable within cells. Functionalization of AuNPs with nonsteroidal anti-inflammatory 2-arylpropionic drugs is proposed. These drugs are widely prescribed and are able to generate cytotoxic singlet oxygen, which induces cell tumour death. Their photophysical properties have been well characterised in solution. However, to the best of our knowledge, functionalization of AuNPs with drugs of this family has never been performed. The photophysical properties of the new nanomaterials will be studied in different microenvironments that tend to mimic cellular milieus, such as micellar or microemulsion media. Investigation of their photobehaviour in the presence of proteins is also planned. Finally, studies in an intracellular environment and in vivo will also be performed in order to check the potential application of the new conjugates as biosensors or photodynamic therapy agents.

Keywords: nanoparticles,fluorescence,laser flash photolysis,biosensors,intracellular analysis,photodynamic therapy
The Proton Size Puzzle: Testing QED at Extreme Wavelengths (QED-PROTONSIZE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 2497664.0
EU funding (EUR): 2497664.0
Participants: 1
Project status: CLOSED

A key component of the Standard Model is Quantum Electrodynamics (QED). QED explains e.g. the anomalous magnetic moment of the electron and small energy shifts in the energy structure of atoms and molecules due to vacuum fluctuations. After decades of precision measurements, especially laser spectroscopy in atomic hydrogen, QED is considered the most successful and best-tested theory in physics. However, in 2010 precision spectroscopy in muonic-hydrogen (where the electron is replaced with a muon) has lead to discrepancies in energy level structure that cannot be accounted for. If QED is considered correct, then one way of interpreting the results is that the size of the proton is different in normal (electronic) hydrogen by as much as 4% (a 7 sigma effect) compared to muonic hydrogen. Despite great theoretical and experimental efforts, this 'proton size puzzle' is still unsolved. I propose to perform precision spectroscopy in the extreme ultraviolet near 30 nm in the helium+ ion, to establish an exciting new platform for QED tests and thereby shed light on the proton-size puzzle. The advantages of helium ions over hydrogen atoms are that they can be trapped (observed longer), QED effects are more than an order of magnitude larger, and the nuclear size of the alpha particle is better known than the proton. Moreover, the CREMA collaboration has recently measured the 2S-2P transition in muonic He+ (both 3He and 4He isotopes) at the Paul Scherrer Institute. Evaluation of the measurements is ongoing, but could lead to an 8 fold (or more) improved alpha-particle radius, so that it is no longer limiting QED theory in normal He+. I will use several ground-breaking methods such as Ramsey-comb spectroscopy in the extreme ultraviolet to measure the 1S-2S transition in trapped normal electronic He+, with (sub) kHz spectroscopic accuracy. This will provide a unique and timely opportunity for a direct comparison of QED in electronic and muonic systems at an unprecedented level.
Cosmology with future large-scale surveys (COSMOFLAGS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

New challenges for large galaxy surveys: Forthcoming galaxy surveys will probe volumes much larger than current ones, and measuring galaxy clustering at these scales will represent a new challenge that has not been properly analyzed so far. This project aims at developing a theoretical understanding and a pipeline to maximize the scientific output of forthcoming galaxy surveys, by modeling and making available to the scientific community a way to fully use the cosmological volumes probed, without introducing any bias due to an incorrect treatment of large-scale galaxy clustering. This project plans to develop and apply an improved formalism to data from current and future galaxy surveys to perform precise cosmological tests using galaxy clustering analyses. We will also perform an accurate forecasting of performances of instruments in different configurations and for different observing strategies; this will help defining and optimizing the survey strategy and final implementation of next generation experiments like Euclid and the SKA. The interaction between the researcher and the host institution will allow the development of a formalism for describing and measuring the large-scale galaxy bispectrum, a fundamental ingredient of next generation measurements from cosmological surveys. Finally, we will investigate the optimal way to combine two future experiments of great interest for the European scientific community: Euclid and the SKA.

Keywords: cosmology,astrophysics,galaxy surveys,telescopes,general relativity,dark energy,primordial universe,statistical analysis,mission planning