Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Druggable Small Molecule Inhibitor of MEIS Proteins (MEISi)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Türkiye
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

MEISi is the first innovative product of Meinox as a druggable substance, owing to its years of research on MEIS biology (published in prestigious journals like Nature and Cell Stem Cell, and PCT patented - pending national entry in 44 countries). Meinox targets the deadliest noncommunicable diseases (NCDs); cancer, CVDs and diabetes, together accounting for nearly 71% of all deaths globally. Never ending efforts and global targets in tackling these diseases show the importance of the development of more effective therapeutics. MEISi is a druggable target-based small molecule, developed and validated by Meinox. MEISi inhibits the activity of MEIS protein which plays a critical role in cell metabolism and associated with NCDs. The benefit it presents to the targeted drug discovery market is to provide tools to modulate molecular mechanisms of the NCDs. The massive sizes of oncology and cardiovascular drug markets (USD $ 29.3B globally) indicate the significance of the small molecule drug discovery market which motivates Meinox to target €10M market share in 3 years after commercialization. Meinox is a deep-tech startup established in 2018 with the main focus on novel and high-level pharmaceutically active ingredients. The company aims to research, develop, produce and market first-in-class, selective drug-like small molecule inhibitors of MEIS, PBX and TGIF2 proteins and their co-factor HOXA9. Meinox aims to conduct a feasibility study with a risk analysis based on different market regulations. In order to improve the commercialization plan, potential customers of MEISi will be identified and strategies will be developed for each segment by defining proper channels for the MEISi product family. Market entry strategy will be validated by performing market analysis and competitive benchmarking in the target markets.

Keywords: small molecules,meis1,meis2,oncology
Demonstrating sustainable value creation from industrial CO2 by its thermophilic microbial conversion into acetone (PYROCO2)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Germany,Spain,Italy,Italy,Sweden,Switzerland,Norway,Thailand,Norway,Norway,France,France,France,Czechia,Denmark,United Kingdom
Call: Closing the industrial carbon cycle to combat climate change - Industrial feasibility of catalytic routes for sustainable alternatives to fossil resources (H2020-LC-GD-2020-5, 2020)
Start date: 2021-10-01
End date: 2026-09-30
Duration (months): 60.0
Total project cost (EUR): 43887817.75
EU funding (EUR): 39999561.18
Participants: 22
Project status: SIGNED

Achieving climate neutrality by 2050 requires a rapid paradigm shift towards the implementations of new, climate positive solutions that can boost the European market. Emerging new solutions for carbon capture, utilization, and storage (CCUS) have great potential to decarbonize production in the chemical industry, while allowing value creation from own carbon emissions. In this context, the PYROCO2 project will demonstrate the scalability and economic viability of carbon capture and utilization (CCU) to make climate-positive acetone out of industrial CO2 and renewable electricity derived hydrogen. Core of the technology is an energy-efficient thermophilic microbial bioprocess that is projected towards a reduction of 17 Mt CO2eq by 2050. The acetone produced by the PYROCO2 process will be demonstrated as an ideal platform for the catalytic synthesis of a range of chemicals, synthetic fuels, and recyclable polymer materials from CO2, generating a portfolio of viable business cases and pre-developed processes for replication and commercialisation. The PYROCO2 demonstrator plant will be able to produce up to 4000 tonnes acetone annually from 9100 tonnes of industrial CO2 and green hydrogen. It will be located at the industrial cluster of Heroya Industrial Park in southern Norway, a strategic placement that guarantees access to CO2 feedstock and green energy at a competitive price and connects several carbon-intensive industries with chemical production through industrial symbiosis. From here, the PYROCO2 project will represent a key driver for the emergence of CCU Hubs across Europe. Besides the large-scale demonstration and full financial, regulatory, and environmental assessment of the PYROCO2 technology, the project will explore the sphere of public acceptance and market exploitation to further encourage the emergence of the CCU market.

Keywords: carbon dioxide,gas fermentation,industrial biotechnology,process scale up,chemical catalysis,acetone,c3 platform chemical production,decarbonization,synthetic fuels,polymer materials
Innovation-fuelled, Sustainable, Inclusive Growth (ISIGrowth)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Switzerland,Slovenia,France,United States,United Kingdom,United Kingdom
Call: The European growth agenda (H2020-EURO-SOCIETY-2014, 2014)
Start date: 2015-05-01
End date: 2018-06-30
Duration (months): 38.0
Total project cost (EUR): 3073610.0
EU funding (EUR): 2498610.0
Participants: 8
Project status: CLOSED

ISIGrowth aims to offer comprehensive diagnostics of the relationships between innovation, employment dynamics and growth in an increasingly globalized and financialised world economy, and, on the grounds of such analysis, elaborate a set of policy scenarios and deliver a coherent policy toolkit able to achieve the Europe 2020 objectives of smart, sustainable and inclusive growth. ISIGrowth brings together researchers from eight international institutions that have contributed to some of the most cutting edge areas of innovation studies (e.g. systems of innovation; technological trajectories/paradigms; industry dynamics) and areas that connect understanding of economic growth at the macro, meso and micro level. Key individuals leading the work packages have shaped these areas internationally and have expertise in managing successful international projects (including EU ones) at the highest level. The research agenda is ambitious and transformative, while building solidly on the foundations of the EC 2020 strategy (and the Innovation Union in particular), so to create policy recommendations that can both improve the EC2020 strategy as well as connect it to the fundamental need facing policy makers today in the face of one the largest financial and economic crisis in history: the relationship between innovation policy, financial market reform, and macroeconomic stimulus policy. ISIGrowth will be policy focussed, with policies emerging from a strong interaction between key theoretical insights (e.g. from Schumpeterian economics of innovation and Keynesian demand policies), with key empirical studies (using cutting edge methods in complexity science, non parametric statistics, as well as detailed case studies of business and industry histories). This theoretical and empirical interaction will be embedded in a dynamic process of engagement with stakeholders in our cutting edge and innovative Civil Action Network (CAN) and Business Forum (BF).

Keywords: structural change,inequality,globalization,de industrialisation,financialisation,innovation policies,aggregate demand management policies
Phenylene-Bridged Grossly Warped Radical Nanographenes (NanoRad)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Here, I propose the exploitation of hitherto unknown grossly warped cationic nanographenes and investigate their unique properties with a view to energy storage and luminescent devices. This Action combines aspects of odd-numbered ring (heptagonal) aromatic cations and open-shell aromatic systems, which are both underutilised in contemporary chemistry. The project will lend new fundamental insights into their self-assembly, optoelectronics, and redox chemistry, bringing them into the mainstream. Investigating these materials will also give insights into the roles of heptagonal defects in carbon nanomaterials, e.g., graphene. The primary objectives of this proposal are (1) to develop scalable synthetic routes to as yet unexplored open-shell warped nanographene ions containing tropylium cation (TP) cores, (2) to investigate and characterise their optical and electronic spin properties and (3) to carry out in depth DFT calculations.

Keywords: polycyclic aromatic hydrocarbon,graphene,radicals,molecular materials
Characterizing Underground storage organs For their Archaeological investigation (CHUFA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

The aim of this proposal is to stablish a systematic methodology for the study of Underground Storage Organs (USOs), commonly known as roots, tubers or bulbs, creating a digital reference collection database and developing experimental archaeology. By doing this, the CHUFA project will remarkably contribute to the advance in the study of food plants among hunter-gatherer Prehistoric groups. Underground Storage Organs (USOs) are plant structures that store mostly carbohydrates and water and they had a key role in different capital moments of human history. However, they are not always well represented in the archaeological record, due to recovery and methodological constrains. This project will deal with the methodological aspects of USOs analysis. The identification of USOs is based on the detailed description of their anatomical structures: outer features of small-sized tubers, and inner cell organization for smaller fragments, for which till date SEM has been used. However, there are serious limitations when dealing with these remains: very few reference materials available, there is no reference collection for other markers such as use-wear or starches and the SEM observation implies sample coating, hindering the possibility of observing the remains from several angles. The main objectives of this proposal are: a) Application of new methods to study parenchymatous tissue remains (ESEM, 3Dscanner and microCT), b) Creation and publication of a botanical reference collection of USOs using the new methods and c) Creation of a data base on use-wear traces and residues on experimental material related to USOs labour. Through its interdisciplinary approach this project will provide archaeobotanists and use-wear analysis specialists with reference material for the identification of USOs and their processing in archaeological sites and fill in this gap in Hunter-Gatherer investigation.

Keywords: archaeobotany,experimental archaeology,archaeological hunter gatherer economy,use wear analysis,starches analysis,underground storage organs usos
Air Launch space Transportation using an Automated aircraft and an Innovative Rocket (ALTAIR)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Switzerland,Norway,Belgium,France,France,France
Call: Independent access to space (H2020-COMPET-2015, 2015)
Start date: 2015-12-01
End date: 2019-11-30
Duration (months): 48.0
Total project cost (EUR): 4275671.25
EU funding (EUR): 3503748.75
Participants: 9
Project status: CLOSED

ALTAIR’s strategic objective is to demonstrate the feasibility of a new cost effective and reliable space launch system for the access to Low-Earth Orbit (400-1000 km) of small satellites ranging from 50 to 150 kg. The ALTAIR launch system aims to be the expected answer to the needs of small satellites users, providing an affordable and adapted access to space service, without the constraints of current rideshare launch options. ALTAIR will boost space applications to the benefit of an increased spectrum of users, from classic satellite operators to academics and research centres. To support this ambitious goal, the ALTAIR system combines an innovative semi-reusable concept and the integration of relevant technologies in all parts of the system. ALTAIR is an innovative air-launch system using a reusable unmanned aircraft carrier optimised specifically for this mission. The expendable rocket launch vehicle, which is released at high altitude, associates green propellant hybrid propulsion, lightweight composite structure, innovative avionics and a versatile upper-stage, providing mission flexibility. Cost-effective ground operations are obtained through innovative ground systems architecture. ALTAIR will pave the way for a feasible system ready to address the market’s need through an original approach associating a cost-oriented preliminary design of the whole system (carrier vehicle, launch vehicle and ground segment) using advanced Multidisciplinary Design Optimisation techniques, and the definition of a credible development roadmap and business model, supported by market analyses. The design will be supported by flight experimentations for key technologies using the existing small scale demonstrator EOLE. The 36-month ALTAIR project benefits from a solid and proven heritage, and gathers the experience of 8 partners from 6 countries (including industrial companies, research centres and a technical centre of a space agency), for a total EC contribution of 3.5 M€.

Keywords: semi reusable system,air launch,hybrid propulsion,light weight structures
The European plug-in to the global Research Data Alliance (RDA Europe 4.0)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Coordination and support actions
Countries involved: Germany,Ireland,Italy,United Kingdom,United Kingdom,United Kingdom
Call: Policy and international cooperation measures for research infrastructures (H2020-INFRASUPP-2017-1, 2017)
Start date: 2018-03-01
End date: 2020-09-30
Duration (months): 31.0
Total project cost (EUR): 3584141.5
EU funding (EUR): 3500000.0
Participants: 7
Project status: CLOSED

RDA Europe 4.0 addresses the INFRASUPP-02-2017 call targeting the area “European support to the Research Data Alliance, RDA” designing Europe’s contribution to implementation of an effective governance model and strategy in RDA global, while ensuring that RDA delivers on locally relevant issues. RDA Europe 4.0 focuses on the need for open and interoperable sharing of research data & on the need to build social, technical and cross-disciplinary links to enable such sharing on a global scale. It strives to do this with its community-driven and bottom-up approach launched since 2012. In fact, RDA Europe 4.0 directly builds on the current RDA Europe effort, by efficiently bringing in the organisations that implemented RDA Europe since 2012. The scope of RDA Europe 4.0 is to become the centrepiece for an EU Open Science Strategy through a consolidated European network of National Nodes, bringing forward an RDA legacy in Europe, providing skilled, voluntary resources from the EU investment to address DSM issues, by means also of an open cascading grant process. The ambitious, 27-month project is implemented by 5 beneficiaries (Trust-IT Services, Gottingen State University Library, the Digital Repository of Ireland at the Royal Irish Academy, the Digital Curation Centre and the RDA Foundation), skillfully supported by 9 National Nodes which carry out specific operational activities & act as national champions for their respective region. One of the specific goals of RDA Europe 4.0 is to complete a capillary European network by on-boarding additional 13 nodes by project end. Main Outputs: Expansion from 9 to 22 national nodes in EU; 7500+ individual members & 75 organisational members; 9 RDA recommendations as ICT technical specifications; consolidated programme for experts, early careers, ambassadors & adoption projects; 5 international RDA plenary meetings; integration with EOSC, ESFRI & other pan-EU initiatives; RDA Europe self-sustained after project completion.

Keywords: research data,international cooperation,data management,interoperability,data infrastructure
Smart Distribution Grid: a Market Driven Approach for the Next Generation of Advanced Operation Models and Services (DOMINOES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Research and Innovation actions
Countries involved: Spain,Finland,Finland,United Kingdom,United Kingdom,Portugal,Portugal,Portugal,United Kingdom,Portugal
Call: Next generation innovative technologies enabling smart grids, storage and energy system integration with increasing share of renewables: distribution network (H2020-LCE-2017-SGS, 2017)
Start date: 2017-10-01
End date: 2021-06-30
Duration (months): 45.0
Total project cost (EUR): 3996125.0
EU funding (EUR): 3996125.0
Participants: 11
Project status: CLOSED

The DOMINOES project aims to enable the discovery and development of new demand response, aggregation, grid management and peer-to-peer trading services by designing, developing and validating a transparent and scalable local energy market solution. The market can be leveraged to share local value, increase renewable energy accessibility and make better use of local grids by Distribution System Operators (DSO), Prosumers/Consumers, Energy Retailers and other key stakeholders. The project will show how DSOs can dynamically and actively manage grid balance in the emerging future where microgrids, ultra-distributed generation and energy independent communities will be prevalent. Best value will only emerge if these resources and stakeholders can be connected to both DSO activities and the centralized market mechanism. The project will establish solutions for this challenge by addressing the following steps: 1. Design and develop a local energy market architecture 2. Develop and demonstrate ICT components enabling the local market concept 3. Develop and demonstrate balancing and demand response services supporting the local markets 4. Design and validate local market enabled business models 5. Analyze and develop solutions for secure data handling related to local market enabled transactions With these steps, the DOMINOES project is able to address all the requirements of the LCE-01-2017 call. The project will deliver 1. new business models for demand response and virtual power plant (VPP) operations; 2. tools and technology validation for demand response services; 3. services based on smart metering; 4. methods to utilize VPPs and microgrids as active balancing assets; 5. secure data handling procedures in local markets. These results will be validated in three validation sites in Portugal and Finland. A DSO environment in Évora (Portugal), a VPP site distributed across bank branches in Portugal and a microgrid site in Lappeenranta (Finland).

Keywords: transparent local energy markets
Disruptive targeted drug delivery system via synergistic combination of intelligent DNA molecular machines and gated mesoporous nanoparticles (SMARTRIOX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-06-01
End date: 2021-10-31
Duration (months): 41.0
Total project cost (EUR): 2847667.5
EU funding (EUR): 1993367.25
Participants: 1
Project status: CLOSED

Although there are Triple Negative Breast Cancer (TNBC), the most aggressive type of Breast Cancer (BC), accounts for 15-25% of all BCs. Yearly 200,000 women are diagnosed with TNBC, of which 100,000 are diagnosed with metastatic disease at the primary diagnosis. TNBC lacks a recognized molecular target, making it an orphan disease: no effective treatment is available to date. The poor prognosis of patients suffering from TNBC makes it extremely challenging for both oncologists and patients. TNBC is more aggressive because all its receptors (Estrogen/Progesterone/Herceptin) are negative, and targeted and endocrine therapies are not helpful. TNBC shows a shortened disease-free interval in the neoadjuvant and adjuvant settings and a more aggressive course in the metastatic setting.The mainstay treatment for TNBC is Doxorubicin, a potent anthracycline chemotherapy, which nonetheless, has substantial toxicities (cardiac, immune, digestive and epithelial) that limit its maximal dose and render the tumour cells resistant to it. As a result, patients cannot be treated with a high enough and effective dose.In response, Triox Nano has developed TXN770: an innovative bionanoparticle based anticancer treatment. TXN770 has a DNAzyme machine cap that recognizes cancer cells and releases the chemotherapy exclusively inside them, responding to pre-programmed threshold levels of Mg2+ and ATP that are present primarily at the target TNBC cells. This allows using 4 times lower concentrations of Doxorubicin, which in turn causes less side effects and achieves a higher effectiveness. It also prevents cancer cells from becoming resistant to Doxorubicin.TrioxNano will address a BC world market of $10.4 billion, expected to grow to $17.2 billion in 2021. TrioxNano projects €547M in profit, with a ROI of €15 per euro invested in the project and in turn will help ease the economic burden of TNBC in National Health Services while positioning itself as a leading company in treatment of TNBC.

Keywords: targeted rug de ivery system,nanoparticles,dna molecular machines