Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Evolution of multicellularity and somatic cell specialization (EVOSOM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-05-01
End date: 2023-04-30
Duration (months): 72.0
Total project cost (EUR): 2128602.0
EU funding (EUR): 2128602.0
Participants: 1
Project status: SIGNED

The evolution of multicellularity allowed specialization of cells into functions that support rather than cause propagation. While yielding immense gain of function, the organisation of these somatic cells into tissues and organs required novel cell-cell signalling systems. We seek to identify the genetic changes that caused transitions to multicellularity and enabled cell specialization. We use genetically tractable Dictyostelia with multicellular structures that contain from 1 to 5 cell-types to address these fundamental questions. Dictyostelia evolved from unicellular Amoebozoa and are subdivided into 4 major groups, with most novel cell-types appearing in group 4. We found that gene expression patterns changed most frequently at the transition between groups 3 and 4, and that across groups ~10% of genes were alternatively spliced in the 5’UTR, indicative of promoter elaboration. Among known genes essential for multicellular development, those involved in intracellular signal processing were mostly conserved between Dictyostelia and unicellular Amoebozoa, while those encoding exposed and secreted proteins (ESPs) were unique to Dictyostelia or groups within Dictyostelia. Starting from a hypothesis that diversification of ESPs and gene regulatory mechanisms are major drivers of multicellular evolution, we will place unicellular relatives of Dictyostelia under selection to induce multicellularity, establish which genes are most changed in evolved populations and whether this involves ESP families that are also most changed in Dictyostelia. We will overexpress altered genes in unicellular forms to assess whether this induces multicellularity. We will retrace evolution of cell specialization by lineage analysis and phenotyping and seek correlations between cell-type innovation and alternative splice events and with emergence of novel signalling genes. Causality will be assessed by replacement of genes or promoters with ancestral forms in evolved species and vice versa

Keywords: evolution of multicellularity,evolution of development,dictyostelium,social amoeba,evolution of sociality
Spatio-temporal control of the Src kinase activation through Optogenetics in Cell invasion (OSS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Cell signaling is a complex system that coordinates cell actions in response to environmental inputs. Signaling pathways are often seen and investigated as on/off networks, but the reality of the intensities and spatio-temporal organization of these networks has been poorly integrated with the dynamics of cellular outputs in response to specific environmental inputs. In the OSS project we aim to approach this general problem by focusing on a specific cellular function, cell invasion (the hosts area of expertise). We propose to 1) use the formation of invadosomes, characteristic acto-adhesive structures important for cell invasion as a specific cellular function, to address these fundamental questions 2) and target the pleiotropic tyrosine kinase Src that has the ability to induce cell invasion globally by acting on cell adhesion, migration, contractility and invadosome dynamics independently of any environmental regulation, to investigate how a biological signal can be dynamically encoded into specific multifarious cellular outputs. Our hypothesis is that specific spatio-temporal patterns of Src activation could be the basis of its pleiotropicity. Thus, the first step of the OSS project will be to use Src biosensors to observe different patterns of Src activation and correlate them with the dynamics of Src-dependent cellular outputs (such as induction of invadosomes). Secondly, we will directly control spatio-temporal Src activity in live cells using optogenetics, a powerful and innovative approach that will allow us to mimic the observed patterns of Src activation and to create new patterns in order to explore dynamic equilibrium between Src signaling and its specific cellular outputs. This project is at the cross-road of signaling theory in biology, cell biology of acto-adhesive structures and biotechnology fields. The goal of the OSS project is to actively manipulate signals in space and time with the ultimate aim to control dynamic process of cell invasion.

Keywords: dynamic cell signalling,cell invasion,invadosomes,src kinase,optogenetics,mechanotransduction
EU eHealth Interoperability Conformity Assessment Scheme (EURO-CAS)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Coordination and support actions
Countries involved: Italy,Germany,Italy,Austria,Belgium,Greece,Croatia,Poland,France,Netherlands,Luxembourg,Denmark,Portugal
Call: EU eHealth Interoperability conformity assessment (H2020-SC1-2016-CNECT, 2016)
Start date: 2016-12-01
End date: 2018-11-30
Duration (months): 24.0
Total project cost (EUR): 995287.5
EU funding (EUR): 995287.5
Participants: 16
Project status: CLOSED

EURO-CAS, European eHealth Interoperability Conformity Assessment Scheme aims at maintaining and developing the adoption and take-up of testing the interoperability of ICT solutions against identified eHealth standards and profiles defined in the eHealth European Interoperability Framework (eEIF). The key deliverable is a sustainable Conformity Assessment Scheme (CAS) for Europe. Based on recommendations of the Antilope project and the state-of-art in interoperability testing in eHealth, EURO-CAS is committed to putting in place an operational CAS based on ISO/IEC 17025 that will meet the interoperability requirements of European eHealth projects as well as national and regional eHealth programs. This will allow testing the interoperability capabilities of products and services for a single digital market in eHealth in Europe in line with the Digital Agenda for Europe and based on international profiles and standards. The project will gather a multi-disciplinary consortium of high-level expertise, including organizations focused on implementing international standards as well as industry stakeholders and healthcare providers that will 1) review the state of the art of existing interoperability CAS, 2) collect the requirements and needs from cross border, national/regional levels, 3) establish the CAS for Europe with implementation guidelines and governance, 4) propose business models for the CAS for Europe, 5) validate results and foresee national/regional adoption, 6) inform and educate eHealth stakeholders and motivate industry and projects to participate in a European accreditation process. The CAS for Europe will provide a comprehensive framework completing the eEIF and aligned with the international CAS. Its flexibility will allow better sustainability and harmonization at European, national and regional levels.

Keywords: ehealth interoperability,eeif,accreditation,antilope,identified standards and profiles,testing,iec 17025
Peptide Dynamic Amphiphiles for Gene Therapy and Macromolecular Delivery (TraffikGene)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The delivery of exogenous nucleic acids and related macromolecules is one of the most encouraging tools for the future of human health. However, the delivery of the required genetic cargo still constitutes an important challenge. Although non-viral vectors are still in their preliminary clinical steps they are rising up as a real alternative for gene therapeutics. Oligopeptides and polymer cell penetrating materials constitute one of the most promising alternatives for the protection, transport and controlled release of different macromolecular cargos. Under the framework of the ERC-Stg_DYNAP we have methodology that employs dynamic covalent bonds to connect peptide/polymer scaffolds with different aldehyde tails (cationic, hydrophobic, glycans, PEGs, etc.). This key synthetic advantage allows the quick identification of different peptide vehicles for customized cargos. The recent interest of important industrial partners in our technology confirms the strong interest and potential impact of our platform. TraffikGene will diversify the potential market applications of this technology and will allow us to reach a higher level of control for the market transference. We will optimize peptide libraries for the delivery of new nucleic acids (i.e. mRNA) in in vitro and in vivo. The potential commercial success will be maximized by diversification of the applications in gene therapy, cytosolic delivery, antibody transport, cell targeting, blood brain barrier crossing, etc. A market analysis will identify industrial needs, market niches, financial requirements and stakeholders for commercialization. The best future IPR strategy will be carefully evaluated and decided (i.e. product licensing, product development, spin-off, etc.). TraffikGene will allow us to identify and solve challenges required to improve, diversify and exploit the strong potential market applications of our discoveries in the field of gene and macromolecular controlled delivery.

Keywords: peptide chemistry,supramolecular chemistry,penetrating peptides,membranes,gene delivery,gene therapy,macromolecular delivery
Migrant and Refugee Rights Index for the Middle East and North Africa (MRRI-MENA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-08-05
End date: 2021-08-04
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

As of 2000 the stock of migrants in the Global South has been growing at a faster rate than in the Global North, and as of 2016 countries in the Global South host eighty-four per cent of the world’s refugees. Yet the majority of academic literature on migration examines movement from the Global South to the Global North, and there is significantly less theorization about how host countries in the Global South treat migrants and refugees. My project addresses this gap through an examination of host state policies toward and treatment of migrants and refugees in the Middle East and North Africa (MENA), a region that has seen increasing patterns of migrant and refugee settlement in the last three decades. My project will develop an index that rigorously measures host state policies toward migrants and refugees using a minority rights framework. The results of this study will provide MENA host states, European donor states, and international humanitarian organizations with a useful index tool for highlighting areas in which legal and social measures should be strengthened via targeted funding and capacity-building to counteract exclusion and provide stronger protection for migrants and refugees. This project directly corresponds to the Horizon 2020 policy priority of creating inclusive, innovative and reflective societies through the promotion of coherent and effective cooperation with third countries, and by addressing issues of identities, tolerance and cultural heritage. Completing this research as a postdoctoral scholar at the Institute for Minority Rights at EURAC will equip me with skills in the use of a multi and interdisciplinary approach combining legal, political and sociological research in order to address the complex issue of minority and migrant rights for this project and going forward as a scholar. In particular, I will gain exposure to the Institute’s use of theoretical frameworks for developing indicators that measure minority rights protection.

Keywords: migration,refugees,minority rights,middle east and north africa
Microfluidic Multi-Micropollutant Remediation (M3R)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-01
End date: 2023-02-28
Duration (months): 24.0
Total project cost (EUR): 196707.84
EU funding (EUR): 196707.84
Participants: 1
Project status: CLOSED

The rapidly growing impact of xenobiotic chemicals (Endocrine disrupting compounds) on the environment has prompted the development of new processes for the treatment of wastewaters produced by industries and municipalities. Recently, European Commission voted to re-examine its drinking water and commission decided to include three Endocrine disrupting compounds (Bisphenol A, Nonylphenol, and 17β-Estradiol) in the list of benchmark parameters for drinking-water monitoring, in line with latest recommendations of the World Health Organisation (WHO). Recently, the capability of lignin-modifying enzymes for degradation of xenobiotics and recalcitrant pollutants has generated a considerable research interest in this area of industrial/environmental microbiology. Lignin-modifying enzymes can be also used to break down and reduce the harmful activity of hazardous substances, due to the similarity of their chemical structure with that of lignin. The goal of this innovative project is to relate the expertise of the ER in ligninolytic enzymes with the expertise of a start-up in microfluidics and microfluidic systems. By combining these two technologies, we aim at creating a superior, more efficient system able to rapidly perform the treatment of wastewaters. The resulting system should be small, energy-efficient (involving low pressures, typically below 200 Pa), and made of a high number of microfluidic layers to allow for a high wastewater volume treatment (typically up to 50 m3/day). The high-volume high-efficiency target will be made possible using a microfluidic technology developed and patented by the host company. The resulting technology is foreseen to address the current challenge of increasing water pollution and bring affordable, sustainable solutions for all communities, large and urban or small and rural alike.

Keywords: water treatment,purification,endocrine disrupting compounds,laccase enzyme,microsystem,microfluidics
SoBigData++: European Integrated Infrastructure for Social Mining and Big Data Analytics (SoBigData-PlusPlus)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Spain,Spain,Estonia,Italy,Italy,Italy,Italy,Germany,Italy,Italy,Belgium,Greece,Switzerland,Finland,Hungary,Sweden,Bulgaria,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2019-1, 2019)
Start date: 2020-01-01
End date: 2024-12-31
Duration (months): 60.0
Total project cost (EUR): 9997172.5
EU funding (EUR): 9997172.5
Participants: 32
Project status: SIGNED

SoBigData++ strives to deliver a distributed, Pan-European, multi-disciplinary research infrastructure for big social data analytics, coupled with the consolidation of a cross-disciplinary European research community, aimed at using social mining and big data to understand the complexity of our contemporary, globally-interconnected society. SoBigData++ is set to advance on such ambitious tasks thanks to SoBigData, the predecessor project that started this construction in 2015. Becoming an advanced community, SoBigData++ will strengthen its tools and services to empower researchers and innovators through a platform for the design and execution of large-scale social mining experiments. It will be open to users with diverse background, accessible on project cloud (aligned with EOSC) and also exploiting supercomputing facilities. Pushing the FAIR principles further, SoBigData++ will render social mining experiments more easily designed, adjusted and repeatable by domain experts that are not data scientists. SoBigData++ will move forward from a starting community of pioneers to a wide and diverse scientific movement, capable of empowering the next generation of responsible social data scientists, engaged in the grand societal challenges laid out in its exploratories: Societal Debates and Online Misinformation, Sustainable Cities for Citizens, Demography, Economics & Finance 2.0, Migration Studies, Sport Data Science, Social Impact of Artificial Intelligence and Explainable Machine Learning. SoBigData++ will advance from the awareness of ethical and legal challenges to concrete tools that operationalise ethics with value-sensitive design, incorporating values and norms for privacy protection, fairness, transparency and pluralism. SoBigData++ will deliver an accelerator of data-driven innovation that facilitates the collaboration with industry to develop joint pilot projects, and will consolidate an RI ready for the ESFRI Roadmap and sustained by a SoBigData Association.

Keywords: e infrastructures,social mining,big data,platform,eosc,open science,multidisciplinary,ethics
Secretion, Autophagy and their role in Neurodegeneration (SAND)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Germany,Italy,Germany,Ireland,Switzerland,Switzerland,Sweden,Norway,France,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 4076578.42
EU funding (EUR): 4076578.42
Participants: 17
Project status: SIGNED

Neurodegenerative disorders are among the leading causes of mortality and will become more relevant in our continuously aging societies. Most neurodegenerative disorders exhibit alterations in proteostasis, i.e. an imbalance between protein production, sorting and degradation. The secretory and the autophagic pathways are two major regulators of cellular proteostasis and their crosstalk is likely to be relevant for neurodegeneration. Thus, there is a need to train a new generation of early stage researchers that will exploit and translate the fundamental biology principles of autophagy, secretion and their crosstalk in human diseases. Our ETN will explore the links between Secretion, Autophagy and their role in NeuroDegeneration (SAND) and will consolidate the position of Europe as a leader in this field by: (i) providing a framework for training and supervision of students to provide them with a repertoire of transferrable and scientific skills that will equip them for careers in academia and industry. (ii) bringing together leading experts in the fields of autophagy, secretion and neurodegeneration from academia and industry into a consortium that involves 22 participants from 12 countries (12 academic beneficiaries from 13 institutions, 3 industry beneficiaries, 4 non-academic partners and 3 academic partner institutions) (iii) using a unifying strategy such as a common stock of cell lines for screening and a common electronic custom-made database tailored to the needs of our consortium (iv) combining complementary expertise such as systems biology, chemical biology, model organisms (zebrafish, drosophila and mouse models), cellular models (neuronal cell lines, primary neurons and patient-derived iPSC neurons) and techniques (e.g. EM, intravital imaging, proteomics, microfluidics) (v) exploiting the translational potential because the network contains three clinically active neurologists, non-academic partners interested in development of drugs and diagnost

Keywords: autophagy,neurodegeneration,secretion,golgi apparatus,secretone
A novel characterization- and reliability-oriented simulation software for dielectric-based nano-electronic devices (MDLab Ginestra)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Italy
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

MDLab (Modeling Dielectric Laboratory) has developed a novel micro- and nano-electronic devices simulation software focused on the physical phenomena occurring in the dielectric layers i.e. charge and ion transport, charge trapping, and structural degradation. The MDLab software has several distinctive features (i.e., automatic interpretation and calibration, full reliability simulation, focus on dielectric-based devices with a multi-scale atomic approach, flexible graphical interface resembling a measurement instrument) compared to the TCAD software available on the market, which represents a great opportunity to successfully enter the market by responding to needs currently not covered by competitive commercial TCAD tools. Thanks to a novel user interface concept designed to be intuitive, a broad adoption of the software is expected from non-simulation-experts, who can benefit from the Graphical User Interface (GUI) simplicity, allowing connecting the electrical curves to the atomic/physical properties of the dielectric materials in an intuitive simulation environment. MDLab aims at becoming an European and worldwide company developing simulation software for electronic devices, changing the way simulation tools are used in the semiconductor industry, thanks to the friendly and flexible interface connecting electronic device performance/reliability to atomic device properties.

Keywords: modeling and simulation,dielectric,micro and nano electronic device semiconductor