Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Chimeric Antigen Receptors (CARs) for Advanced Therapies (CARAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Germany,Germany,France,United Kingdom,United Kingdom
Call: Tools and technologies for advanced therapies (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 5989158.75
EU funding (EUR): 5989158.75
Participants: 9
Project status: CLOSED

Chimeric antigen receptors (CARs) are artificial surface receptors that can be introduced into somatic cells by genetic engineering and that act as recognition molecules like antibodies or T-cell receptors. In this respect, CARs are increasingly used for cellular therapy to redirect T-cells specifically towards killing of cancer cells. Recent success stories of cancer therapy with CAR modified T-cells have raised enormous scientific and public expectations to cure severely ill patients. However, there are still many obstacles to overcome for translation into clinics because the technology for GMP-compliant manufacture of genetically modified cellular products is extremely complex and expensive. Moreover, CAR therapy needs to be improved with respect to off-target activity, safety and potency. Consequently, the envisaged project is overall aiming at a particular technological breakthrough in cellular cancer therapy by delivering a comprehensive CARAT platform explicitly tailored for automated, easy-to-handle and cost-efficient manufacture of CAR-modified ATMP. Specifically, we aim: (a) to implement unique next-generation cell processing tools like the CliniMACS Prodigy (b) to develop advanced enabling technologies to obtain more effective and safer cellular products by improved gene delivery and innovative CARs design (c) to assemble tools and technologies towards an integrated CARAT process for automated GMP-compliant manufacture of gene-modified T-cells (d) to demonstrate proof-of-concept and regulatory compliance (e) to disseminate broadly applicable, simplified CAR T-cell technologies In summary, our vision is to overcome current hurdles for translation of cellular therapies and to elevate them to the next level of standard-of-care thus serving patients with so far incurable solid tumours and hematologic malignancies. Thereby, we will empower Europe to become a global leader in the development and commercialisation of CAR T-cell tools and technologies.

Keywords: chimeric antigen receptors,cars,t cells,cell therapy,gene therapy,cell manufacture,atmp,cancer,regulatory compliance,cell isolation,automation,monitoring,logistic control,safety
Modular cell factories for the production of 100 compounds from the shikimate pathway (SHIKIFACTORY100)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Germany,Spain,Switzerland,Netherlands,Denmark,United Kingdom,United Kingdom,Portugal,Portugal,United Kingdom
Call: Synthetic biology to expand diversity of nature's chemical production (RIA) (H2020-NMBP-BIO-2018-two-stage, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 7997537.51
EU funding (EUR): 7995343.75
Participants: 13
Project status: SIGNED

Chemical synthesis is often difficult and may be subject to unclear mechanisms, frequently producing undesired by-products, while the complexity of some compounds may rendered them virtually unattainable. Nature can provide a wealth of products, however typically at very low concentrations, which makes their extraction process expensive. Conversely, microbial production is a well-established process for compounds naturally produced by the hosts or for which there are fully characterised biosynthetic pathways. However, relying on nature’s diversity as a provider for industrial applications typically requires major screenings for pathways, genes and optimisation of cell factories for the efficient production of the target compounds. SHIKIFACTORY100 project aims towards the production of a universe of more than 100 high-added value compounds from the shikimate pathway, a hub in cell metabolism, through the development of an optimised shikimate chassis) and the proposal and implementation of novel biosynthetic routes exploring enzyme promiscuity to propose new pathways for the production of known and newly designed compounds. To champion SHIKIFACTORY100 project a consortium with some of the most relevant players in Europe has been assembled, covering research leading institutions in computational design, rapid prototyping and in vivo implementation of pathways and cell factories. As such, six world-leading research partners, four biotechnology SMEs with complementary focus areas and one large industrial company have been integrated. The research partners will be responsible for novel methods for pathway discovery and compound design, collaborating with the SMEs in the implementation and optimisation of the chassis, while SMEs and industrial partners will lead the assessment of the products and the exploitation of the results for different application areas. The industrial partner will be responsible for the validation of the production.

Keywords: cell factories,natural products,metabolic engineering,microbial chassis,bio based chemicals,synthetic biology,rapid prototyping
Localized catalytic hotspot detection, manipulation, and creation for Energy Innovations (LoCatSpot)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-07-01
End date: 2022-06-30
Duration (months): 24.0
Total project cost (EUR): 144980.64
EU funding (EUR): 144980.64
Participants: 1
Project status: CLOSED

Throughout the European Union, questions about the sustainability of our lifestyles have become a strong motivation for innovations in chemical energy conversion and storage. Hydrogen is expected to play the key role in future developments. The electrochemical hydrogen evolution reaction (HER) is an important and future-oriented way of producing hydrogen. Tremendous efforts have been made to develop new materials as substitutes for Pt-based HER catalysts. Two dimensional transition metal dichalcogenide (TMD) are promising replacements due to their admirable catalytic activity and low cost. However, the expectations in TMDs as alternative HER catalysts have not yet been fulfilled. It is well known that local variations in the chemical composition and morphological characteristics (planes, edges) influence catalytic effects and thus change electrochemical activity. The development of advanced nanocomposites of two or more TMDs is therefore a fascinating and targeted approach which faces several challenges. One major challenge, especially for complex materials where modifications can cause multiple changes, is pinpointing the electrochemical activity to individual surface characteristics to identify catalytic hotspots. Another big challenge is the selective creation of catalytic hotspots up to the construction of well divined and highly efficient nanocomposite structures. The scanning electrochemical microscope enables the correlation of electrochemical activity to surface characteristics as well as the template-free chemical structuring of surfaces. In particular, the direct read out after induced modifications will deliver unprecedently detailed information about catalytic hotspots. This project aims to apply localized electrochemistry to provide clear solutions for both challenges and to finally path the way to new advanced 2D materials for further energy related innovations.

Keywords: localized electrochemistry,transition metal dichalcogenides,local deposition
The World's first cost effective, electronically steerable, digital, low profile, phased array antenna to enable high speed satellite communications on the move (Phasor)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-2-2014, 2014)
Start date: 2015-05-01
End date: 2017-03-31
Duration (months): 23.0
Total project cost (EUR): 2925093.75
EU funding (EUR): 1516545.0
Participants: 1
Project status: CLOSED

The demand for mobile communications is growing at compound rate CAGR of 61% p.a. and forecast to do so beyond 2022. Global mobile data traffic grew 81 % in 2013 and reached 1.5 Exabyte’s per month at the end of 2013, up from 820 petabytes per month at the end of 2012. Users now demand fast and affordable connectivity when and wherever they are. The growing use/ownership of laptops, tablet computers and larger smart phones has also led to an increasing demand for high quality content such as HD video on the move. Current satellite communications antennas cannot fully meet this large and growing need: Mechanically steerable antennas which are bulky, heavy, require maintenance and pose considerable vehicle integration challenges. Phased arrays based on military technology are too costly for commercial applications. Existing low cost antennas trade-off the cost of the antenna against the requirement for much more expensive satellite bandwidth per Mbps transmitted. Their performance is also too limited for use in certain geographical areas (particularly at large skew angles). The overall objective of this project therefore is to successfully refine and scale up for market readiness the world’s first cost effective, electronically steerable, digital, low profile phased antenna to enable high speed satellite communications on the move. This will enable us to gain a substantial market share in the € 1.185bn Broadband Satellite Communications-on-the-Move (COTM) market and the associated antenna market which amounts to €0.39bn. Both of which are growing rapidly. We predict that we can achieve a 2.5% market share by 2020, generating total revenues of €134m and a cumulative EBITDA of €63m, creating 781 jobs. Our prototype system technology is demonstrated and proven in a relevant environment and at TRL6. This project will allow us to demonstrate the market disruptive system in an operational environment and then fully scale up the system to market readiness.

Keywords: phased array antenna,ku band,steerable,low profile,high speed,cotm,communications on the move,digital,electronic,phasor,ka band
Setting up high-value Sea cucumber chain in Europe through a new fishing trawl with no environmental impact and advanced processing equipment (TOPBALAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Cross-cutting marine and maritime research
Action type: SME instrument
Countries involved: Iceland
Call: Supporting SMEs efforts for the development - deployment and market replication of innovative solutions for blue growth (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-03-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

sea cucumbers are considered a delicacy in Asian cuisine, and of cultural and medical importance. They are exploited in >70 countries and exported to SE Asia, where consumers pay from €300 to €1,500/kg for a premium dehydrated product. Sharp rise of Asian demand in the last years has led to overexploitation of 66% of sea cucumber fisheries globally. Current bottom trawls for sea cucumber fishing have low efficacy, high by-catches, and cause irreversible damage to the marine seabed, so they are banned in several European countries. On the other hand, sea cucumbers are very perishable and need to be processed by hand when dried quality individuals are sought to meet Asian standards. High man power costs in Europe to fully process sea cucumbers have hindered exportation of dried sea cucumbers to Asia from the only producing European country, Iceland. Half-processing frozen sea cucumbers are not only 15% less profitable than dried ones, but also imply elevated shipping costs since frozen individuals weigh only 50-70% less than fresh ones after catch, while percentage is reduced to 5% for dried cucumbers. A great market opportunity exists for a profitable fishery and processing industry to be developed by means of TOBALAT novel technology in European countries with high sea cucumber potential such as Norway, Ireland, Scotland, Denmark, Netherlands, or Germany. TOPBALAT consists of (i) A trawl highly-effective (>90%), respectful with the environment (<5% by-catches), and 30% cheaper than current sky-dredges; and (ii) An accurate processing machinery integrating all manipulating steps almost without man-power (<92%) producing top-quality dry sea cucumbers to be exported at competitive cost. Thus, the whole value chain of getting dry Bêche-de-mer is definitively improved. AURORA SEAFOOD, the applying SME, forecasts €35.7 M cumulative revenues (2020-2022), with €5.5 M profit, and staff increase by 15 people. Payback period is 1 year, and profitability ratio by 2022 will

Keywords: sea cucumber,b che de mer,cucumaria frondosa,trawl,dredge,fishing gear,processing machinery,sustainable fishery,asian market
ElectroMechanoActive Polymer-based Scaffolds for Heart-on-Chip (EMAPS-Cardio)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Germany,Lithuania,Switzerland,Hungary,France,Czechia,Portugal
Call: Next generation organ-on-chip (RIA-LS) (H2020-NMBP-TR-IND-2020-twostage, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 6622957.96
EU funding (EUR): 5355921.25
Participants: 9
Project status: SIGNED

Cardiovascular diseases (CVDs) account for 45% of deaths in Europe and are estimated to cost the EU economy €210 billion a year. However, only four drugs targeting cardiovascular diseases have been approved for use in the last decade. Thus, models that could effectively simulate diseased tissues, would enable the accurate assessment of the efficacy of the pharmaceuticals, and would accelerate drug development are urgently needed. The main bottleneck towards such models is the foetal-like state of the human induced pluripotent stem cell (hiPSC) derived cardiomyocytes (CMs). That is hiPSC-CMs do not reach adult-like maturity. The objective of this project is to produce a platform for growth and maturation of cardiac microtissues for adult-like organotypic models in healthy and diseased states. To achieve that, biomimetic microenvironment that provides all the needed stimuli (electrical, mechanical, topological (3D environment) and biochemical (release of active molecules)), during the maturation of hiPSC-CMs will be developed. This will be achieved by combining electro-mechanoactive polymer-based scaffolds (EMAPS) with bioactive membranes. To characterize the effects of CVD drugs, the contractility of the microtissue will be monitored continuously and simultaneously (over 24-wells) using the sensors developed during the project. To increase the sensitivity and accuracy of the model, deep-learning based algorithms to detect the effects of drugs in vitro will be developed and verified. The goals will be achieved by a multidisciplinary consortium with complementary know-how of three academic units and seven small companies. The increased sensitivity and accuracy of organ-on-chip devices is a needed leap in technology that will accelerate new drug development without the need for animal models; the project aims to provide a platform for the realization of such physiologically-relevant organotypic models.

Keywords: growth and maturation of cardiac microtissues,engineered cardiac scaffolds,mechanical and electrical stimulation,electrophysiology,biosensing,drug screening,organ on chip,organotypic models
FAçade bio-CArbon based anti UV coating to prevent DEterioration of wooden buildings (FACADE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Slovenia
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 150040.32
EU funding (EUR): 150040.32
Participants: 1
Project status: CLOSED

Façades play crucial roles in the building safety, comfort, and aesthetics. As an envelope for buildings, they are in constant interaction with outside environment. Ultraviolet (UV) solar radiation absorbed by lignin – constituting up to 40% of wood – initiates the weathering of wood. The weathering process induces colour changes, surface fibres to loosen and erode, allowing humidity to penetrate in depth in wood, and causing checks and a raised grain. It is therefore crucial to limit the weathering effects that can then lead to deterioration of wood by using coatings to protect its surface. UV absorbers enhance the durability of wood outdoors by absorbing incident radiation and by converting it into heat, which is then dissipated. Carbon-based materials are potential UV stabilizers thanks to combined effects of physical screen, UV absorbance, and radical trap. Bio-carbon is a carbon-based product obtained from thermal decomposition of organic materials at elevated temperatures. Organic materials can be wastes from the agricultural or forest industries, with currently little or no economic value. Bio-carbon presents a wide range of properties that can be tailored by the manufacturing process. To the best knowledge of the Experienced Researcher (ER), no prior research on using bio-carbon for UV stabilization has been reported. The FACADE project proposes to develop a competitive sustainable bio-sourced anti-UV coating to protect wooden façades, using bio-carbon as UV-stabilizer. The FACADE project tackles challenging concepts with innovative solutions and is expected to provide breakthroughs for advancing the use of bio-carbon in new applications and proving a fundamental understanding of the UV protection mechanisms of nanoscale carbon particles. Through the MSCA program activities, particularly mentoring young researchers, organizing events and managing projects, the ER will make a significant step in her career by gaining professional maturity and independence.

Keywords: bio carbon,carbonized biomass,sustainable carbon,ultraviolet,weathering,facade,wood protection
A platform supercharging residential property valuations. (Geowox)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Ireland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 1560000.0
EU funding (EUR): 1092000.0
Participants: 1
Project status: CLOSED

Geowox provides data-driven residential property valuations in real-time. Our clients are mortgage providers and mortgage investors, who are still served by external manual surveyors, delivering paper or spreadsheet based valuations via e-mail. This process is inaccurate, slow and costly. Geowox brings together the efficiency of big data solutions and the due diligence performed by accredited surveyors. We bring accredited surveyors onto our platform, (supercharging) providing them with Automated Valuation Models (AVMs) and report building modules. We offer specific applications for i) new mortgage valuation (a one time, single unit, home-visit based valuation for new mortgages) and ii) existing mortgage revaluation (a periodic, non-home visit based revaluation during the mortgage lifetime), which are the most common tasks performed by surveyors. The EU/US residential valuation market is worth €1.5bn annually. €500m are served by software solutions, with no accredited surveyor intervention. The remaining €1bn is served by over 150,000 accredited surveyors, performing similar property valuations. The core of our proprietary platform has two main elements: i) a proprietary address encoder, able to enrich uniquely identifiable geo-coordinates and property characteristics to addresses from a wide array of sources. ii) an AVM able to predict residential property value to a Median Absolute Percentage Error (MdAPE) of <10%, with the goal to reduce this to <5% by 2021.

Keywords: real estate,fintech,proptech
Unraveling the regulatory network of developmental programmed cell death in plants (PROCELLDEATH)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cellular, Developmental and Regenerative Biology
Panel description: Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Belgium
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2020-03-31
Duration (months): 60.0
Total project cost (EUR): 1499746.0
EU funding (EUR): 1499746.0
Participants: 1
Project status: CLOSED

Programmed cell death (PCD) is a fundamental biological process that actively terminates a cell’s vital functions by a well-ordered sequence of events. In both animals and plants, various types of PCD are crucial for development, health, and the responses to various stresses. Despite their importance, only little is known about PCD processes and their molecular control in plants. Still, an intricate regulatory network must exist that renders specific plant cell types competent to initiate and execute PCD at precisely determined developmental stages. I recently established a powerful developmental PCD model system in Arabidopsis thaliana, based on a PCD process occurring during root cap development. This root cap model has the potential to revolutionize existing concepts of plant PCD, as it combines a precisely predictable PCD process in easily accessible cells on the root periphery with the abundance of resources available for Arabidopsis research. Exploiting the root cap system will enable me to tackle unresolved fundamental questions about the regulation of developmental PCD in plants: How do cells acquire PCD competency during differentiation? Which signals trigger PCD execution at just the right moment? What are the actual mechanisms that disrupt the vital functions of a plant cell? I will obtain answers to these questions through a comprehensive strategy combining complementary approaches, taking advantage of cell-type specific transcriptomics, forward and reverse genetics, advanced live-cell imaging, biochemistry, and computational modeling. Our unpublished data point to the existence of a common core mechanism controlling PCD not only in the root cap, but also in other vital organs including the vasculature, anthers, or developing seeds. Thus, this project will not only be significant to advance our knowledge on PCD as a general developmental mechanism in plants, but also to generate new leads to tap the so far underexploited potential of PCD in agriculture.

Keywords: developmental programmed cell death in plants,calcium,cell biology of programmed cell death,sub cellular dynamics,transcriptional regulation,computational modelling