Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Clinical validation and production upscaling of a novel product for healing of Pressure Ulcers, Leg Ulcers and Diabetic Foot Ulcers. (DERMAREP)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Italy,Ireland,Norway,France,France
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2019)
Start date: 2019-10-01
End date: 2023-03-31
Duration (months): 42.0
Total project cost (EUR): 4284339.29
EU funding (EUR): 2999037.5
Participants: 5
Project status: SIGNED

A chronic wound (such as Leg Ulcer (LU), Pressure Ulcer (PU) and Diabetic Foot Ulcer (DFU) can be defined as one that has failed to proceed through an orderly and timely reparative process to produce anatomic and functional integrity within a period of 3 months or that has proceeded through the repair process without establishing a sustained and anatomic and functional result. Chronic wounds may require several years to heal, and some remain unhealed for decades. During this time, patients can experience severe pain, significant emotional and physical distress, reduced mobility and social isolation. LU, PU and DFU are a major healthcare cost for all developed countries. The main driver for growth in cost is the treatment of chronic and complex wounds in the aging population, complicated by the increase in diabetes and other metabolic disorders. LUs account for $50Bn of global wound care burden in 2015 and are to reach $53Bn in 2020. DFUs account for $52Bn – and are to reach $56Bn by 2020. Further, PUs account for $41Bn of global wound care burden in 2015 – and are to reach $47Bn by 2020. We have developed an innovative wound dressing, DermaRep™, that is based on biomaterial derived from Eggshell Membrane (ESM) – a by-product readily available in the egg industry. The purified form of ESM is called Purified Eggshell Membrane Protein (PEP). DermaRep™ is disruptive and will become the benchmark in the wound healing market as it directly addresses the healthcare needs by providing a novel wound care product that is significantly more effective than current Standard of Care (SoC, relatively non-expensive silicon, foam and hydrocolloid dressings) and at least as effective as existing State of the Art (SoA) collagen-based dressings.

Keywords: ulcer,leg ulcer,pressure ulcer,diabetic foot ulcer,wound dressing,chronic wound
Modulated Composite Structures: A 3D Bulk Approach to Incoherent Hetero-Structure Interface Engineering in Oxides for Future Low Temperature Energy Applications (MODCOMS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-05
End date: 2020-02-04
Duration (months): 24.0
Total project cost (EUR): 178993.8
EU funding (EUR): 178993.8
Participants: 2
Project status: CLOSED

Interfaces between oxides can provide entirely new ways to realize novel properties. The goal of this research project is to further clarify the fundamental relationships between composition, crystal structure and ionic transport properties in a novel system based on the hexagonal YMnO3 type structure. This system shows a remarkably large reversible - oxygen storage capacity (LR-OSC) at very low temperatures 150-400C, and the experienced researcher(ER) hypothesizes that this transition may strongly depend on the energy related to the hetero-structure interface (HSI) formation that is naturally formed in modulated composite structures (MODCOMS); in this case between an YMnO3 and Y2Mn2O7 based structure in 3D (i.e., throughout the bulk material). Here, selected promising compositions from the ER’s preliminary results, where cationic substitutions have stabilized the mentioned transition from previously >100bar O2 gas pressure to 1atm P(O2), and can be synthesized under ambient air conditions will be used to make detailed studies possible at practical conditions. The ER will study the structural, thermogravimetric, electronic, thermodynamic and kinetic properties at the host at Northwestern University who is a well renowned expert in the field of oxides. The results from experiments will be linked to computational modeling studies at the returning host group at Chalmers. The overall goal will be to find an experimental and theoretical guiding principle to design HSI in MODCOMS, to combine the excellent performance achieved from HSI in 2D by thin film techniques, with the low production costs for bulk materials by using interfaces in 3D in MODCOMS. The new insights will lead to new breakthroughs in the design of novel materials systems that can utilize interfacial transport in 3D to realize ionic transport and oxygen storage at very low temperatures; properties highly desirable for clean energy technologies like solid oxide fuel cells and heterogeneous catalysts.

Keywords: nanoionics,oxide ion conductors,hetero structure interphases,oxygen storage,interfaces,storage,ion transport
Structural and biochemical characterization of pre-recombination complexes (BRCA2Interact)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 2
Project status: CLOSED

Homologous recombination (HR) is an essential DNA repair mechanism and defects in different HR factors are linked with disease and cancer pre-disposition. The RAD51 recombinase plays a central role in HR, forming nucleoprotein filaments at sites of DNA damage and promoting homologous pairing and DNA strand exchange. RAD51 filament formation is mediated by the BRCA2 tumour suppressor, mutations in which lead to a high incidence of developing breast cancer. BRCA2 interacts with other HR factors, such as PALB2 and members of the RAD51 paralog family. Many of these proteins also function as tumour suppressors. The host laboratory has purified full-length BRCA2 protein and shown that it facilitates RAD51-mediated HR by acting as a molecular chaperone for RAD51 filament formation. This offers a unique position to extend our understanding of pre-recombinational protein assembly by inclusion of additional critical HR factors, and answer the important question how PALB2 and the RAD51 paralogs coordinate their activities with BRCA2 to promote the assembly of RAD51 filaments. To achieve this, I propose to: i) Characterize the biochemical and structural properties of RAD51 paralog complexes ii) Define the interplay between BRCA2, PALB2, and the RAD51 paralogs in forming pre-recombination complexes for RAD51 assembly, using biochemical approaches and electron microscopic visualisation. Given the importance of HR and its role in tumour avoidance, I anticipate our results to provide significant new insights into the molecular mechanisms underlying genome instability. Also, they may uncover novel targets for therapeutic intervention for breast cancer. Together, the proposed research will not only substantially advance knowledge of DNA repair but will also provide me with invaluable training in biochemistry, electron microscopy and project management in a world-class research environment. As such, it forms the perfect platform from which to launch my independent research career.

Keywords: dna repair,homologous recombination,rad51 paralogs,brca2 rad51 palb2,cancer
BioNetIllustration: User centric illustrations of biological networks (BioNetIllustration)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-06-20
Duration (months): 24.0
Total project cost (EUR): 166156.8
EU funding (EUR): 166156.8
Participants: 1
Project status: CLOSED

In living systems, one molecule is commonly involved in several distinct physiological functions. The roles of molecules are commonly summarized in pathway diagrams, which, however, are abstract, hierarchically nested and thus is difficult to comprehend especially by non-expert audience. The primary goal of this research in visualization is to intuitively support the comprehensive understanding of relationships among biological networks using interactively computed illustrations. Illustrations, especially in textbooks of biology are carefully designed to clearly present reactions between organs as well as interactions within cells. Automatic generation of illustrative visualizations of biological networks is thus the technical content of this proposal. Automatic generation of hand-drawn illustrations has been a challenging task due to the difficulty of algorithmically describing a human creative process such as evaluating and selecting significant information and composing meaningful explanations in a visually plausible manner. Our high-level idea in BioNetIllustration is to simulate this process by decomposing the entire problem into multiple steps including content-driven layout and illustration design as well as spatio-temporal event transitions across multiple representations. As a pioneer study on illustrations, a new visualization framework for these network illustrations will be developed. This study can be achieved by matching the unique competences of the researcher and the host research group and allows an innovative synthesis to produce hand-drawn like illustrations of biological networks. The project also involves experts from several disciplines including network and medical visualization, data mining, systems biology as well as perceptual psychology. The result will provide a new direction for physiological process analysis and accelerate the knowledge transfer not only within experts but also to the public.

Keywords: information visualization,illustrations,graph,biological network
From Aquileia to Singidunum (Belgrade), reconstructing the paths of Roman travelers (RecRoad)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-02-01
End date: 2018-01-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

The RecRoad project aims to reconstruct the Roman road going from Aquileia, in the north-east of Italy, to Singidunum, on the Danube river. This was one of the main road axes of the Empire and it connected the Venetian area with the Pannonia Superior and the Danubian limes: the road was longer than 450 miles, passing through the Alps, it ran along the river Sava, crossing its course several times. The road's general layout can be followed in the itinerary sources but an attempt to accurately reconstruct the course of the road on the ground has never been tried before and may greatly improve our knowledge of the evolution of the territories that it crossed over the time. After an in-depth study of the original itinerary of the road, the project aims also at the analysis of the consequences of its construction on the landscape from different point of view (culture, settlement dynamics, religion, trade, …), so that better comprehension of the territorial and cultural connections, will be possible. To reach these goals, the project will consider and use all the sources and the new technologies avalaible to archaeologists, in a multi-disciplinary approach. All the collected and generated information will be geo-referenced and published in an online Atlas. The main output of the project will be an interactive atlas available online, where it will be possible to visualize the reconstructed route in its geographical context, the reliability degree of the individual segments and the sources that were identified with reference to the single stretch of the road to which they pertain. In addition, new strategies and initiatives for the protection and knowledge dissemination will be developed. For the first time, all the sources today avalaible to archaeologists will be used to identify the original track of a Roman road and to study the importance of the consequences that its presence had on the territory and on the way ancient people conceived the landscape where they lived.

Keywords: roman archaeology,landscape archaeology,ancient route,remote sensing,ancient,landscape,danube,upper moesia,webmapping,geomatics,roman road,aquileia,singidunum
A Unified Framework of Business Cycles and Household Portfolios: Income Risks, Asset Liquidity, and Inequality (LiquidHouseCycle)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-06-01
End date: 2023-05-31
Duration (months): 72.0
Total project cost (EUR): 1277830.0
EU funding (EUR): 1277830.0
Participants: 1
Project status: SIGNED

Households face large idiosyncratic income risks and use their wealth to self insure. In doing so, they make portfolio choices we can summarize grosso modo as choices between liquid (safe and nominal) and illiquid (risky and real) assets. These choices have the potential to create strong aggregate repercussions as investments in real assets create an immediate demand for goods, while liquid nominal savings only when someone else uses the funds to invest or consume. As a result, portfolio choices are key for economic dynamics and important for the propagation of monetary and fiscal policy. Moreover, household portfolio positions and the liquidity of assets itself become an important determinant of aggregate savings and investment. Yet, they are widely disregarded in standard business cycle models today. The proposed research therefore develops a novel framework that allows us to understand this nexus--a framework that studies business cycles, household portfolios, income risks, and asset liquidity in unison. This new framework allows us to address a wide array of important macroeconomic questions of our time: how wealth inequality and stabilization policies interact, how monetary policy redistributes, how a housing freeze can create a recession as big as the last one, and finally, why crises are particularly severe in times of high household debt. To develop this framework, empirical and theoretical work has to go hand in hand: First, I document the historical movements in the distribution of household (and firm) portfolios to understand how and whose portfolio positions change over the cycle and in response to shocks. Second, I document the cyclical movements in asset liquidity. Third, I develop a theoretical framework that allows us to understand the implications of changes in asset liquidity in a setup with incomplete markets and nominal rigidities. Finally, I make liquidity fluctuations endogenous and augment the model with a structure of overlapping generations.

Keywords: macroeconomics,business cycles,household portfolios,liquidity,incomplete markets,income risks,inequality
Next Generation Modelling and Forecasting of Variable Renewable Generation for Large-scale Integration in Energy Systems and Markets (Smart4RES)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Greece,France,France,France,Netherlands,Netherlands,Denmark,United Kingdom,Portugal,Portugal
Call: Research on advanced tools and technological development (H2020-LC-SC3-2019-ES-SCC, 2019)
Start date: 2019-11-01
End date: 2023-04-30
Duration (months): 42.0
Total project cost (EUR): 3999915.0
EU funding (EUR): 3999915.0
Participants: 16
Project status: SIGNED

The Smart4RES project aims to bring substantial performance improvements to the whole model and value chain in renewable energy (RES) forecasting, with particular emphasis placed on optimizing synergies with storage and to support power system operation and participation in electricity markets. For that, it concentrates on a number of disruptive proposals to support ambitious objectives for the future of renewable energy forecasting. This is thought of in a context with steady increase in the quantity of data being collected and computational capabilities. And, this comes in combination with recent advances in data science and approaches to meteorological forecasting. Smart4RES concentrates on novel developments towards very high-resolution and dedicated weather forecasting solutions. It makes optimal use of varied and distributed sources of data e.g. remote sensing (sky imagers, satellites, etc), power and meteorological measurements, as well as high-resolution weather forecasts, to yield high-quality and seamless approaches to renewable energy forecasting. The project accommodates the fact that all these sources of data are distributed geographically and in terms of ownership, with current restrictions preventing sharing. Novel alternative approaches are to be developed and evaluated to reach optimal forecast accuracy in that context, including distributed and privacy-preserving learning and forecasting methods, as well as the advent of platform-enabled data-markets, with associated pricing strategies. Smart4RES places a strong emphasis on maximizing the value from the use of forecasts in applications through advanced decision making and optimization approaches. This also goes through approaches to streamline the definition of new forecasting products balancing the complexity of forecast information and the need of forecast users. Focus is on developing models for applications involving storage, the provision of ancillary services, as well as market participation.

Keywords: towards 100 renewable integration,weather forecasting,renewable energy forecasting,data science,digital energy transition,storage management,ancillary services,smart grid
Bringing the human being into the digital loop (Digital Iris)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Austria
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-02-01
End date: 2019-09-30
Duration (months): 20.0
Total project cost (EUR): 3299267.14
EU funding (EUR): 2309487.0
Participants: 1
Project status: CLOSED

In the era of the digital revolution, pushing the smart wearables to the forefront, bridging the gap between the human being and digital or other machines is the key of future applications. The existing technical solutions are still limited in their impact as they are unable to react to natural human behavior. The biggest disruptive digitizing step aims at detecting and interpreting directly individual behavior in conjunction with the situational environment – wherever, whenever, in whatever situation -, without the need of additional interactions with a device. Eye Tracking (ET) technology measures the eye activity to better understand sight, perception, reaction, and emotions, providing a complete bi-directional interaction with the environment. Existing head-worn ET solutions are only able to work in artificial, controlled lab environments. Viewpointsystem, based on its patented Eye Hyper Tracking (EHT) system, is the only company able to provide a solution that works under uncontrolled real-life environments. “Digital Iris” is the definitive tool to integrate the human being into the digital world. It represents a disruptive leap forward, providing total robustness, reliability and every-day-usability and allowing its use in professional applications whatever the conditions are. The disruptive leap is based on existing know-how, coming from the embedded gaze image processing previously used in the safety-critical automotive world by Viewpointsystem´s experts. Adding to a head worn, functionally robust EHT a robust Augmented Reality element, Digital Iris will generate real-time useful information based on users’ situational environment and reactions. This intuitive ‘Human Machine Interface’ will immerse the user into a complete digital loop, opening up complete new and disruptive applications in industry, mobility and medicine, among others. Digital Iris is a big market opportunity able to generate sales in excess of 100 M€ by 2021 and creating 130 direct jobs

Keywords: eye tracking,human machine interface,perception,emotion,augmented reality,mixed reality
TOWARDS NOVEL NANO-SCALE TECHNOLOGIES BASED ON PHORETIC FLOW EFFECTS (NANOPHLOW)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,France,France,France,Netherlands,United Kingdom
Call: FET-Open research and innovation actions (H2020-FETOPEN-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2021-10-31
Duration (months): 45.0
Total project cost (EUR): 3299670.01
EU funding (EUR): 3299670.0
Participants: 8
Project status: CLOSED

Most devices that transport bulk fluids make use of pressure gradients (`pumps’) or external forces (e.g. gravity powers hydro-electric turbines). Increasingly, modern technology is addressing problems where fluid transport takes place in sub-micron sized channels, or in pores. The physical laws of transport in such channels are qualitatively different from those that determine bulk flow; they are poorly understood and, importantly, barely exploited. The aim of the proposed research is to lay the basis for an entire novel technology where thermal gradients and concentration gradients along nano-sized channels are harnessed to drive devices that have no equivalent on the macroscopic scale. Such gradient-driven surface flows offer a huge scope for fundamental advances with very significant technological implications. We envisage breakthroughs in the area of energy extraction from salinity gradients (`blue energy’), ultra-filtration and desalination, and the development of novel, highly sensitive protein-separation devices. This new approach will surpass the intrinsic limitations of current technologies. The expected huge improvement in efficiency will be a game changer and will break the current barriers in the development of technologies such as e.g osmotic energy harvesting. All the applications share the same underlying science and can therefore be addressed by the proposal team. We will engage with industrial partners inside the team and with new partners that we will approach through our Knowledge Transfer Facilitator, to translate basic science into proofs-of-principle, pilot plants and, subsequently, full scale applications. The potential economic impact of phoretic technologies is difficult to over-estimate: the research is truly high-risk, high-yield. By targeting two diverse applications, we exploit the generic nature of the underlying science. The quality and interdisciplinary nature of the team mitigates the risk of failure.

Keywords: nanofluidics,microfluidics,blue energy,statistical physics,fluid dynamics