Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
European Collaborative Project on Inflamation and Vascular Wall Remodelling in Atherosclerosis (ATHEROREMO)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Finland,Sweden,United Kingdom,Italy,Switzerland,Finland,Germany,Greece,Denmark,Norway,France,France,Netherlands,Germany,United Kingdom,Germany,Germany
Call:  (FP7-HEALTH-2007-A, 2007)
Start date: 2008-05-01
End date: 2013-10-31
Duration (months): 66.0
Total project cost (EUR): 15316907.84
EU funding (EUR): 11691180.0
Participants: 20
Project status: CLOSED

The health of the EC population has never been better. However, serious public health problems remain, which cannot be ignored including high levels of premature death due to cardiovascular diseases. Thus, new preventive, diagnostic and therapeutic strategies against atherosclerotic cardiovascular diseases are needed. The atherosclerotic changes of the vascular wall are central in the development of cardiovascular complications. The traditional view that atherosclerosis is simply a lipid storage disease has recently been challenged by evidence that inflammation plays a central role in all stages of atherosclerosis. However, molecular mechanisms linking inflammation to atherosclerosis development are not fully understood, and this has severely hampered the advance of diagnostic and therapeutic programs. AtheroRemo aims to identify novel inflammatory mechanisms in vascular remodelling by combining the exploration of human biobanks with animal models and established cellular models. This new knowledge will be used to develop new preventive, diagnostic and therapeutic strategies against atherosclerotic cardiovascular disease. AtheroRemo contains several unique strengths: 1) Outstanding expertise on immunity and inflammation. Our expertise facilitates the breakthroughs in the immuno-inflammatory targeted vascular treatments. 2) Finest European cohorts to search for molecular mechanisms behind atherosclerosis development allowing us to combine underlying genetics with lipidomic profiles in multiple cohorts in order to obtain risk factors and biomarker panel related to inflammatory remodelling. 3) Accelerated target validation with novel liposomal-targeted delivery of nucleic acid-based therapeutics in appropriate animal models. Four SME partners able to exploit the new knowledge support AtheroRemo research. Thus, we expect to translate a number of novel findings into potential clinical applications such as new diagnostic tools (biomarkers) and therapeutics.

Keywords: atherosclerosis,remodelling,inflammation,target validation,biomarkers,immunology,liposomes,lipidomics
The Promise and Limits of International Courts and Tribunals – Exploring the Conditions for Effective International Adjudication (SHANYEFFECTIVECOURTS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Individuals, institutions and markets
Countries involved: Israel
Call:  (ERC-2007-StG, 2007)
Start date: 2008-08-01
End date: 2013-07-31
Duration (months): 60.0
Total project cost (EUR): 998400.0
EU funding (EUR): 998400.0
Participants: 1
Project status: CLOSED

The proposed project focuses on the factors that influence the effectiveness of international courts in light of the different social roles that they play in international life. The research hypothesis is that different international courts offer unique combinations of dispute settlement, law-interpretation and law-application services to diverse constituencies, in regard to varying subject areas and pursuant to changing jurisdictional structures. Hence, previous research work on the topic that sought to develop 'one-size-fits all' assessments of efficiency and calls for reform, needs to be supplemented with a more nuanced approach that captures the linkage between the courts' constitutive ethos, their social and political functions and potential impact. As a result, there is need to identify and consider more specific efficiency-enhancing elements and strategies that could help different courts in fulfilling their missions more effectively (e.g., judicial independence, dialogue with other courts, procedural innovations, etc.). The identification of factors influencing the effectiveness of international courts would be facilitated through theoretic research of the law and practice applied by the different courts by a team of junior researchers (post-doctoral, PhD and MA students), headed by a principal investigator, and more practical-oriented research work involving on-site visits, interviews with court officials and litigants and analysis of statistical data. The project will provide national and international decision makers with better tools for measuring the performance of international courts and will serve as the basis for improved decisions relating to the establishment and operation of international courts (e.g., whether to establish new courts, budgetary allocations, selection of cases to be referred, procedural reforms, etc.).

Keywords: international courts,adjudication,effectiveness,dispute-settlement,international law
Establishment of a European parent- and patient-oriented information and communication platform on Congenital Heart Defects (CHD PLATFORM)

Framework: FP7 — Cooperation
Programme: Health
Destination: Other Actions across the Health Theme
Action type: Coordination and support actions
Countries involved: Germany,Spain,Norway,Sweden,Germany,United Kingdom
Call:  (FP7-HEALTH-2007-A, 2007)
Start date: 2008-02-01
End date: 2010-01-31
Duration (months): 24.0
Total project cost (EUR): 824457.64
EU funding (EUR): 745000.0
Participants: 7
Project status: CLOSED

With this support action we intend the establishment of a European parent- and patient-oriented, web-based information and communication platform that helps to build up a large European network on congenital heart defects (CHD PLATFORM). The aim of this platform is to vertically cross-link medical organisations and facilities, physicians and scientists to patients, parents, patients’/parents’-organisations, and in addition to increase public awareness of the growing number of children/patients in our society suffering from congenital heart defects. The intended CHD platform will provide a comprehensible and target group optimised supply of information and should initiate discussion and dialogue between all groups. Background information about new medical research should be processed in close cooperation between scientists, physicians, editors, patients and parents. The platform will also provide media-oriented events such as news, interviews, fact sheets etc. The website is planned to be offered at least partially in different European languages. In addition, information workshops for all concerned groups should be arranged for dialogue and knowledge-transfer, and press conferences launched to inform the public, politics, non-governmental organisations etc. With the establishment of CHD PLATFORM we intend • an intensified dissemination of knowledge and information • an increased spirit of co-operation • the consideration of patients’ and parents’ opinions and points of view • building up trust within patient and parent communities, and strengthening the willingness to participate in research studies • a higher significance and outcome of medical research and clinical studies CHD PLATFORM would support other projects that are intended in the FP7-Health Programme (2007 B, Calls 2.4.2-4 and 4.2-1, see below) as accompanying measure, and promote medical research in Europe concerning this group of patients which continuously grows in size throughout the world.

Keywords: congenital heart defects,communication platform,network across europe,patient/parent-oriented,patient/parent-organisations
FUEL CELL STACK ASSEMBLY AND DIAGNOSTICS (ELECTROCHEM)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-2007-4-3-IRG, 2007)
Start date: 2008-12-01
End date: 2012-11-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Gebze Institute of Technology is actively engaged in research for promoting hydrogen energy technologies in Turkey. Dr. Yazici will work as Senior Scientist to train graduate students on Electrochemistry and develop capabilities on bipolar plate manufacturing and testing for high power density fuel cells. Specific objectives include: -Completing a state of the art assembly and testing laboratory; -Developing thinner bipolar plate materials to compete with metal plates; -Offering semester classes to graduate students on electrochemistry and fuel cells; -Offering university workshops on hydrogen energy technologies; -Submitting proposals for further funding to become Center of Excellence. The United States Department of Energy (DOE) Hydrogen, Fuel Cells & Infrastructure Program’s roadmap for transportation fuel cells identifies energy density, durability, and cost as the primary drivers for rapid commercialization. Bipolar plates have the highest mass and volume of any component in the fuel cell stack. Reduced stack size and weight by making thinner bipolar plates leads directly to increased energy density and lower cost. In this proposal, Dr. Yazici will obtain new graphite materials and characterize them for physical properties and assemble them into fuel cell stacks that may give higher energy density compare to conventional bipolar plates. Funding of this proposal is going to help us to train graduate students on electrochemistry in general and specifically on fuel cell stack assembly and testing. At the same time, experience gained by local or European machine shops during material preparation and processing will support them in future supply-chain.

Keywords: physical sciences,electrochemistry,chemical engineering,materials engineering
Serotonin and GABA-B receptors in anxiety : from developmental risk factors to treatment. (DEVANX)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: France,Germany,Switzerland,Ireland,Spain,Germany
Call:  (FP7-HEALTH-2007-A, 2007)
Start date: 2008-02-01
End date: 2012-07-31
Duration (months): 54.0
Total project cost (EUR): 3788652.8
EU funding (EUR): 2841578.0
Participants: 6
Project status: CLOSED

GABAergic and serotoninergic systems are key players in the control of anxiety states but the precise bases for their action has remained elusive. New findings, brought about by members of this consortium, are radically changing our views on the neurobiological action of these two transmitters and will be the focus of the present proposal. The first original dimension is the discovery of a developmental role of serotonin (5-HT) in the genesis of anxiety disorders, and the finding of interactions between 5-HT-related genes and environmental risk factors. The second new dimension is the discovery that metabotropic GABA-B receptors play a critical role in mediating the anxiolytic effects of GABA, a starting point for the conception and design of novel therapeutic approaches. Finally, recent evidence point to strong reciprocal interactions between the two systems. In this proposal , researchers that are at the forefront of these research domains will build on and extend these promising new findings. The project associates specialists of development, neuronal plasticity, neurobehaviour, neuropharmacology and mouse genetics. The consortium will explore the neuronal circuits mediating the developmental effects of 5-HT by using existing models and by creating new models for site- and time-specific invalidation of 5-HT related genes (Tph2, pet1,VMAT2,5-HT1A-R), focusing on the hippocampus, amygdala and raphe nuclei. They will explore the role of GABA-B receptors in anxiety and the interaction of these receptors with the 5-HT system. The developmental effects of GABA-B receptors and a new generation of GABA-B modulators that produce anxiolytic effects in animal models will be explored. Finally they will investigate how exposure to adverse environments interacts with 5-HT-genes and GABA-B receptor genes to produce anxiety phenotypes. The proposal will bring new knowledge on the neurobiological basis of anxiety, and open up novel therapeutic approaches in anxiety disorders

Keywords: 5-ht,gaba,development,neuronal circuits,genetic factors,5-ht1a receptors,gaba-b receptors,parental care,prenatal stress,hippocampus,amygdala,raphe,anxiety,fear conditionning,innate fear.
The role of striatum in selection of behaviour and motor learning - neuronal code, microcircuits and modelling (SELECT-AND-ACT)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: Sweden,United Kingdom,Israel
Call:  (FP7-HEALTH-2007-A, 2007)
Start date: 2008-08-01
End date: 2012-01-31
Duration (months): 42.0
Total project cost (EUR): 3253587.0
EU funding (EUR): 2495781.0
Participants: 4
Project status: CLOSED

The input layer of the basal ganglia, the striatum, plays a critical role in the control of motor behaviour and cognitive function. It serves as a filter for cortical and thalamic signals and takes part in determining which actions should be performed at a given instant. Our goal is to define the cellular and network organisation underlying decision-making by analysing the microcircuitry of subpopulations of neurons in striatum (interneurons and projection neurons) concerned with the control of different patterns of behaviour, and their input from cortex (pallium), thalamus and the modulatory inputs from dopaminergic, histaminergic and 5-HT neurons. The microcircuitry will be studied in slices of striatum with patch electrode recordings from three or more identified subtypes of neurons at the same time, while synaptic and membrane properties are investigated and also the synaptic response to the different input systems. Specific synaptic connections of the recorded neurons will be identified by electron microscopy and quantitative aspects of the connections of the different classes of neurons will be defined. Striatal neuronal activity will also be studied in behaving animals with multiunit neuronal recording in relation to defined motor behaviours utilizing several vertebrate model systems (lamprey, rodent and primate). The primary focus will be on striato-pallidal projections indirectly controlling motor programs at the brainstem/spinal cord level, rather than via the thalamo-cortical forebrain projections since these projections cannot as easily be interpreted. Neuronal function and synaptic interaction at the microcircuit level will be subjected to a detailed computer modelling based directly on the outcome of the experimental analyses. Plasticity underlying motor learning/synaptic plasticity, particularly in relation to the dopaminergic, 5-HT and histaminergic inputs will also be characterized.

Keywords: striatum,microcircuitry,behaviour,selection,neuronal code
Self assembly into biofunctional molecules, translating instructions into function (BIOFUNCTION)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physical and Analytical Chemical sciences
Countries involved: France
Call:  (ERC-2007-StG, 2007)
Start date: 2008-07-01
End date: 2013-06-30
Duration (months): 60.0
Total project cost (EUR): 1249980.0
EU funding (EUR): 1249980.0
Participants: 1
Project status: CLOSED

The overall objective of the proposal is to develop enabling chemical technologies to address two important problems in biology: detect in a nondestructive fashion gene expression or microRNA sequences in vivo and, secondly, study the role of multivalency and spatial organization in carbohydrate recognition. Both of these projects exploit the programmable pre-organization of peptide nucleic acid (PNA) to induce a chemical reaction in the first case or modulate a ligand-receptor interaction in the second case. For nucleic acid detection, a DNA or RNA fragment will be utilized to bring two PNA fragments bearing reactive functionalities in close proximity thereby promoting a reaction. Two types of reactions are proposed, the first one to release a fluorophore for imaging purposes and the second one to release a drug as an “intelligent” therapeutic. If affinities are programmed such that hybridization is reversible, the template can work catalytically leading to large amplifications. As a proof of concept, this method will be used to measure the transcription level of genes implicated in stem cell differentiation and detect mutations in oncogenes. For the purpose of studying multivalent carbohydrate ligand architectures, the challenge of chemical synthesis has been a limiting factor. A supramolecular approach is proposed herein where different arrangements of carbohydrates can be displayed in a well organized fashion by hybridizing PNA-tagged carbohydrates to DNA templates. This will be used not only to control the distance between multiple ligands or to create combinatorial arrangements of hetero ligands but also to access more complex architectures such as Hollyday junctions. The oligosaccharide units will be prepared using de novo organoctalytic reactions. This technology will be first applied to probe the recognition events between HIV and dendritic cells which promote HIV infection.

Keywords: templated reactions,oligosaccharides,multivalent ligands
Agricultural Revolution in Southern Europe? (ARISE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2007-10-01
End date: 2010-09-30
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

ARISE will provide a detailed survey of the dietary status of Southern Europe’s prehistoric inhabitants in order to examine key issues relating to the transition to farming in this region. The domestication of plants and animals and the spread of ways of life based on these resources was one of the most important events in human history. In Sothern Europe, there is good archaeological evidence for cereal cultivation and animal husbandry between 9,000 to 7,000 years ago; practices that can be traced to their origin in the Near East over a millennia earlier. However key questions remain unanswered or are keenly disputed: Was it a rapid event or a series of drawn-out processes? Did farming arrive as a complete package or were some elements introduced earlier than others? Was this process driven by the movement of people or of ideas? Recent methodological advances in molecular biology and mass spectrometry have provided new analytical tools that are now available to address these questions. Stable isotope analysis of human bones and chemical analysis of food remains on archaeological artefacts have provided spectacular insights into changes in human diets and subsistence practices. However, these have only been applied to sites in Northern Europe; the South has been surprisingly neglected. To re-address this balance, ARISE will apply these state-of-the-art methodologies to bones and artefacts from some of the most important early agricultural sites in the Mediterranean in order to produce a new synthesis of the origins of agriculture in this region. Additionally, ARISE will provide the potential for long-lasting collaboration between the applicant’s new and previous host departments (Universities of York & Rome) and promote his transition to independence as he establishes a new palaeodietary research group at York. To assist this process, the University of York are willing to make additional financial contributions towards the applicant’s reintegration.

Keywords: archaeology,physical anthropology,cultural anthropology,organic chemistry,environmental chemistry,nutritional sciences
Hybrid Fluorescence Molecular Tomography and X-ray Computed Tomography system and method. (FMTXCT)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: Germany,France,Greece,United Kingdom,Switzerland,Spain,Germany
Call:  (FP7-HEALTH-2007-A, 2007)
Start date: 2008-03-01
End date: 2012-08-31
Duration (months): 54.0
Total project cost (EUR): 5839676.0
EU funding (EUR): 4512141.0
Participants: 8
Project status: CLOSED

This proposal offers to combine X-ray CT (XCT) and Fluorescence Molecular Tomography (FMT) into a hybrid, quantitative system and method. The project builds on state-of the-art knowledge that only recently became available in different European states as represented by the partners herein. In return it delivers the first such hybrid system worldwide. The system will operate by 1) co-registering XCT images with highly performing FMT images for merging anatomical, functional and molecular contrast and by 2) combining XCT information into the FMT inversion to provide a system with superior imaging performance. XCT-based correction, as explained in this proposal, can improve FMT performance in a more radical way than corresponding “correction methods” used for improving PET or SPECT images. In this way FMT-XCT can reach the imaging accuracy of radio-nuclei-based tomography hybrid systems. By using fluorescence, FMT-XCT can then enable high flexibility in targeting physiology and molecular function, especially in multi-spectral mode, and high dissemination potential because virtually any biomedical laboratory has access to fluorescence reporting, compared to radio-nuclei based research that requires access to radiochemistry and cyclotron facilities. FMT-XCT aims in advancing small animal imaging and drug discovery with a view towards the clinical application on non-invasive breast cancer imaging. For this reason, focus herein is given to imaging breast cancer and response to therapy. Overall the technology is ideally suited for commercial translation and has the potential to become the method of choice for in-vivo imaging in most biomedical laboratories and in select clinical applications. While it appreciates the value of nuclear imaging methods, this proposal will hopefully raise the funding necessary to establish on European ground a new potent paradigm of in-vivo imaging with high dissemination and application potential and large social and health-care impact .

Keywords: free-space 360-degree fluorescence tomography anatomical functional and molecular imaging