Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
DosiKit, a first portable field medical device for fast triage of people after external irradiation (DosiKit)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: TERMINATED

Acubens was founded in 2014, to develop and commercialize new game-changer medical diagnostic devices around NRBC emergency. Our team gathers young and experimented doctors, and seasoned business managers, uniting their competencies to develop nuclear/radiological/biological innovative transportable biodosimetry devices. Nuclear/radiological accident can expose individuals to radiation, with the need for fast triage of potentially exposed people requiring immediate medical care. There is today a lack of irradiation biodosimetry tools that can be used in the field, by non-specialist staff, giving immediate results and exposure cartography in case of Partial-Body irradiation (PBI). To fulfil this critical unmet need for better initial crisis management, we invented the DosiKit device and fast test (45 minutes) to identify and classify irradiated individuals, directly in the field. This development was initiated in 2009 by the French Atomic Energy Commission within the European Commission program, BOOSTER (‘BiO-dOSimetric Tools for triagE to Responders’), and then continued by Acubens. DosiKit technology is protected by 3 international patents and has reached TRL6 with a prototype validated in a large-scale exercise performed with the French army. Several collaborations are undergoing for biological validation with French research institute and hospitals. Scientific and technical development was published in 3 scientific publications and many international oral communications. A strong contact has established with French, Germany, Israel, US and Singapore armies (LoI). This DosiKit product will be on the market in 2022, starting in Europe and then extending worldwide. Forecasted sales revenue is 15 M€ in 2024. The objectives of this phase 1 SME-Instrument are: (1) the final Biological and Technological validation of the device, (2) IP, FTO, Regulatory and risk assessment studies and (3) a market survey in Europe and USA to schedule our commercial actions.
Real World Handling of Protein Drugs - Exploration, Evaluation and Education (RealHOPE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative 2
Action type: Research and Innovation actions
Partnership: IMI2 (Art-187)
Countries involved: Italy,Italy,Germany,Germany,Germany,Israel,Italy,Italy,Spain,Sweden,Sweden,Switzerland,Sweden,Sweden,Netherlands,United States,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Handling of protein drug products and stability concerns (H2020-JTI-IMI2-2020-20-two-stage, 2020)
Start date: 2021-07-01
End date: 2025-06-30
Duration (months): 48.0
Total project cost (EUR): 7132608.75
EU funding (EUR): 3139983.75
Participants: 27
Project status: SIGNED

RealHOPE will create an understanding of the real-life handling of protein drugs in hospital pharmacy, clinics and in the hands of patients by applying smart tag technologies. Different parameters will be logged and combined with protein characterisation at different stages, as well as with information from EFPIA partners on their drugs in use. Statistical evaluation of the data will be used to identify patterns in handling that are linked to protein destabilisation occurrence and type of protein degradation. Focus interviews with personnel in hospital pharmacies, clinics and with patients/care givers will be used to understand current handling practice and what the desired handling instructions and limitations are. These insights will be used to design in-use mimicking stability protocols for the protein drugs in the project. Ultra-scaled-down devices for stability assessment will be designed to be used in early phase for efficient development cost effective and safe future protein therapies. Protocols and devices will be validated towards the collected handling data base. Interventions in hospital pharmacies using e.g. compounding robots will be investigated. Techniques to assess e.g. aggregate formation in the final drug preparation situation will be evaluated together with SMEs producing analytical tools and hospital pharmacists. The collected data and interviews will form the base of development of teaching materials directed towards different target groups: hospital pharmacists, nurses and patients/care givers. App developers will be active in this part to design attractive and efficient apps for teaching and collecting therapy performance data.

Keywords: in use protein drug handling,printed electronic tags,destabilisation triggers,protein analytics,real life mimicking stability protocols,compounding robot,pharmacy qc instrument,training modules
The critical role of sedimentary trace element fluxes in ocean biogeochemistry (SedTraceFlux)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

Trace elements and isotopes (TEIs) are powerful tools for studying the ocean system and tracing its interaction with the other Earth System components. Many TEIs exert influence on the surface environment by participating in the global carbon and oxygen cycles. Incorporating TEIs into state-of-the-art global models is thus crucial to better predict future changes of ocean biogeochemistry and climate. This effort, however, is hampered by our limited understanding of the source and sink fluxes of TEIs across the sediment-water interface, which are recently hypothesised to play much greater roles in setting the distributions of TEIs in the ocean than previously assumed. Yet insufficient knowledge results in large uncertainties in model implementations of sedimentary fluxes, severely limiting the applications of marine TEIs. The objectives of SedTraceFlux are to constrain the sedimentary TEI fluxes and provide robust parameterizations of such fluxes suitable for global models. This project will focus on iron, neodymium, zinc and their respective isotopes, which are among the most useful TEI tools in oceanography. I will model the chemical speciation and the processes controlling the distributions of these TEIs in sediment pore water and solid phases. The resulting mechanistic parameterizations of sedimentary fluxes will be fine-tuned using Transport Matrix Methods in global biogeochemical modelling. The modelling effort will be complemented by generation of sedimentary Fe data from under-sampled locations. This project represents an ideal synergy between my ability in geochemical modelling and sediment geochemistry, and the expertise of the host group in a broad range of chemical, isotopic and global modelling approaches. It will enhance my innovative potential toward an independent researcher and strengthen the host’s international network and mobility. The results will also help inform the ocean and climate policy-making of the European Union.

Keywords: biogeochemical cycles of trace elements and isotopes in the ocean,trace element flux across the sediment water interface,sedimentary cycles of iron,neodymium and zinc,sediment diagenesis
Modern ATM via Human/Automation Learning Optimisation (MAHALO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Italy,Sweden,Netherlands,Netherlands
Call: Digitalisation and Automation principles for ATM (H2020-SESAR-2019-2, 2019)
Start date: 2020-06-01
End date: 2022-11-30
Duration (months): 30.0
Total project cost (EUR): 997212.5
EU funding (EUR): 997212.5
Participants: 5
Project status: CLOSED

MAHALO asks a simple but profound question: in the emerging age of Machine Learning (ML), should we be developing automation that matches human behavior (i.e., conformal), or automation that is understandable to the human (i.e., transparent)? Further, what tradeoffs exist, in terms of controller trust, acceptance, and performance? To answer these questions, MAHALO will: • Develop an individually-tuned ML system comprised of layered deep learning and reinforcement models, trained on controller performance (context-specific solutions), strategies (eye tracking), and physiological data, which learns to solve ATC conflicts; • Couple this to an enhanced en-route CD&R prototype display to present machine rationale with regards to ML output; • Evaluate in realtime simulations the relative impact of ML conformance, transparency, and traffic complexity, on controller understanding, trust, acceptance, workload, and performance; and • Define a framework to guide design of future AI systems, including guidance on the effects of conformance, transparency, complexity, and non-nominal conditions. Building on the collective experience within the team, past research, and recent advances in the areas of ML and ecological interface design (EID), MAHALO will take a bold step forward: to create a system that learns from the individual operator, but also provides the operator insight into what the machine has learnt. Several models will be trained and evaluated to reflect a continuum from individually-matched to group-average. Most recent work in areas of automation transparency, Explainable AI (XAI) and ML interpretability will be explored to afford understanding of ML advisories. The user interface will present ML outputs, in terms of: current and future (what-if) traffic patterns; intended resolution maneuvers; and rule-based rationale. The project’s output will add knowledge and design principles on how AI and transparency can be used to improve ATM performance, capacity, and safety.

Keywords: machine learning,cdandr,transparency,interpretability,conformance,automation,eye tracking,human machine interaction
The peace-building agency of stigmatized civilian actors in European cities dealing with the consequences of terrorist violence (URPEACE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2023-06-12
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: SIGNED

This study aims to contribute to knowledge about peace-building agency of civilian actors in marginalized social-housing neighborhoods that deal with the consequences of terrorist violence in European cities. The bulk of peace and conflict studies literature has provided insight in the dynamics of violence rather than peace. The innovative character of this study therefore is that it interprets existing and new data on dealing with violence with a novel approach, that of geographies of peace. This approach views peace as an everyday and relational process that is concerned with the building of ever-expanding networks that share life-affirming rather than life destructing values. As a result, peace is always in the making and in interaction with, rather than opposite to, violence. This innovative approach breaks with the tendency of peace and conflict studies to focus on the Global South, state processes and armed conflict and makes it very relevant for studying initiatives in European cities that deal with the aftermaths of paroxysmal violence. With the guidance of swisspeace, a leading institute in peace studies, research results will be translated to practice-oriented recommendations with the objective of gaining more insight into how policy-makers can integrate urban peacebuilding initiatives of civilian actors in security policy.

Keywords: peace,fear,agency,peacebuilding,security policy,geographies of peace
Thermionic Energy Conversion & Storage Applied to Sunlight: Taking Concentrating Solar Power to the next level (TECSAS)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Italy
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-4, 2020)
Start date: 2021-03-01
End date: 2022-08-31
Duration (months): 18.0
Total project cost (EUR): 116071.43
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

Concentrating Solar Power (CSP) has long been seen as one of the main routes for moving towards carbon neutrality, characterised by both overall system efficiency and Levelised Cost of Energy comparable with photovoltaics. Unfortunately, CSP is currently only implemented through very large centralized plant scales (>100 MW capacity), as process economics make this technology unsustainable at a smaller scale. That’s why, apart from few demo-plants, there is no commercial plant available in the 50 kW – 1 MW range. In the AMADEUS FET-OPEN project we have developed a thermionic-based converter, that is applied in TECSAS to concentrated solar energy and is able to selectively absorb the radiation to produce electrical power by exploiting efficiently sunlight and excess heat. When applied in substitution of state of the art traditional passive receiver elements, the proposed TECSAS technology allows a maximum increase of the CSP conversion efficiency from 20% up to 45%, potentially more than twice as much state of the art performances, regardless of the plant size. This can make existing and under construction CSP plants much more efficient, and at the same time allows thinking of scaling down CSP plants to sizes that are currently econonically unsustainable (≤1 MW). The aim of the TECSAS Launchpad project is to evaluate the technological and business feasibility of downscaled CSP plants (≤ 1 MW) powered by our thermionic converter, as well as to assess the willingness to pay of large scale plant owners which want to integrate TECSAS for performance enhancement. If successful, we will prove that CSP can be applied to benefit several industrial settings, small rural communities and other residential applications.

Keywords: concentrating solar power,thermionic energy conversion,business plan,competitivity,innovation
Extracellular Vesicle-Inspired CArdiac Repair (EVICARE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-09-01
End date: 2023-08-31
Duration (months): 72.0
Total project cost (EUR): 1997297.99
EU funding (EUR): 1997297.99
Participants: 1
Project status: SIGNED

More than 3.5 million people are newly diagnosed with heart failure every year in Europe with a long-term prognosis of 50% mortality within 4 years. There is a major need for more innovative, regenerative therapies that have the potential to change the course of disease. My hypothesis is that we can recondition heart failure by stimulating cardiac repair with extracellular vesicles that are derived from progenitor cells. In my laboratory, extracellular released vesicles containing a cocktail of stimulating factors, are amongst the most potent vectors for cardiac repair. To achieve a sustainable and long-term therapeutic effect of these vesicles and enhance cardiac function by stimulating myocardial repair, we will 1) improve local cardiac delivery of progenitor cell-derived extracellular vesicles, 2) understand the mechanism of action of extracellular vesicles, and 3) stimulate extracellular vesicles release and/or production by progenitor cells. These questions form the rationale for the current proposal in which we will co-inject extracellular vesicles and slow-release biomaterials into the damaged myocardium. By subsequent genetic tracing, we will determine fate mapping of injected vesicles in vivo, and perform further mechanistic understanding in in vitro culture models of targeted and identified myocardial cell types. Moreover, we will upscale the vesicles production by progenitor cells further via bioreactor culturing and medium-throughput screening on factors that stimulate vesicles release. The use of stem cell-derived extracellular vesicles to stimulate cardiac repair will potentially allow for an off-the shelf approach, including mechanistic understanding and future clinical use. Additionally, since these vesicles act as a natural carrier system outperforming current artificial drug delivery, we might understand and mimic their characteristics to enhance local (RNA-based) drug delivery systems for cardiovascular application.

Keywords: extracellular vesicles,microrna therapeutics
Read the fine print: Zooming into paleoenvironmental and biogeochemical processes through molecular imaging of biomarker distributions in sediments (ZOOMecular)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-11-01
End date: 2021-04-30
Duration (months): 66.0
Total project cost (EUR): 3000000.0
EU funding (EUR): 3000000.0
Participants: 1
Project status: CLOSED

Lipid biomarkers provide unique information to disciplines such as paleoceanography, paleoecology and biogeochemistry. Factors limiting their scope include high sample demand and analytical complexity, constraining resolution of time and space to decadal and centimeter scales, respectively. However, dynamic interactions between physical, chemical and biological processes are recorded within sedimentary matrices at finer scales; lipid biomarkers could decode this sedimentary fine print if the limitations of resolution could be overcome. In a recent PNAS paper, we have demonstrated that this can be done and shown that µm-scale molecular images of paleoenvironmental and geobiological processes can be obtained directly on surfaces of cut sediment cores via laser desorption ionization coupled to mass spectrometry. The project ZOOMecular will build on this innovation by interrogating laminated sediment archives of Late Quaternary climate change and dissecting the complex environmental and ecological responses at subannual resolution. Through analysis of spatial associations of lipid biomarkers with the sedimentary matrix, we will provide a new view of the mechanisms underlying delivery to and preservation of molecular signals in sedimentary records. ZOOMecular will seek to examine the microbial habitat niches at sedimentary interfaces that are home to globally important biogeochemical processes but that are largely known from studies of cm3-scale samples. To enable these pioneering studies, we will develop innovative analytical protocols for a suite of informative biomarkers and for the acquisition of congruent molecular and elemental maps of geological samples. ZOOMecular will unlock otherwise inaccessible information of broad geoscientific relevance; its goals go far beyond the state-of-the-art and its outcome has the potential to transform biomarker research. Such a project can be successfully realized only within a frontier research scheme as provided by the ERC.

Keywords: analytical geochemistry,palaeoclimatology,palaeoecology,palaeoenvironment,geomicrobiology
Instabilities and homoclinic phenomena in Hamiltonian systems (HamInstab)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Spain
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 1100347.5
EU funding (EUR): 227152.32
Participants: 2
Project status: SIGNED

A fundamental problem in the study of dynamical systems is to ascertain whether the effect of a perturbation on an integrable Hamiltonian system accumulates over time and leads to a large effect (instability) or it averages out (stability). Instabilities in nearly integrable systems, usually called Arnold diffusion, take place along resonances and by means of a framework of partially hyperbolic invariant objects and their homoclinic and heteroclinic connections. The goal of this project is to develop new techniques, relying on the role of invariant manifolds in the global dynamics, to prove the existence of physically relevant instabilities and homoclinic phenomena in several problems in celestial mechanics and Hamiltonian Partial Differential Equations. The N body problem models the interaction of N puntual masses under gravitational force. Astronomers have deeply analyzed the role of resonances in this model. Nevertheless, mathematical results showing instabilities along them are rather scarce. I plan to develop a new theory to analyze the transversal intersection between invariant manifolds along mean motion and secular resonances to prove the existence of Arnold diffusion. I will also apply this theory to construct oscillatory motions. Several Partial Differential Equations such as the nonlinear Schrödinger, the Klein-Gordon and the wave equations can be seen as infinite dimensional Hamiltonian systems. Using dynamical systems techniques and understanding the role of invariant manifolds in these Hamiltonian PDEs, I will study two type of solutions: transfer of energy solutions, namely solutions that push energy to arbitrarily high modes as time evolves by drifting along resonances; and breathers, spatially localized and periodic in time solutions, which in a proper setting can be seen as homoclinic orbits to a stationary solution.

Keywords: hamiltonian systems,arnold diffusion,celestial mechanics,hamiltonian partial differential equations