Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Measles virus Immuno-Therapy for Aggressive Cancers (MITAC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2025 - Short application (HORIZON-EIC-2025-ACCELERATOR-01, 2025)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Despite significant advances in treatment, cancer remains one of the leading causes of death worldwide. Tumors employ diverse survival mechanisms to evade therapies and suppress the host immune system, creating a “cold” immunosuppressive tumor environment. While Immune Checkpoint Inhibitors (ICIs) have demonstrated success in treating several solid cancers, significant challenges remain, including immune-related side effects and resistance of non-infiltrated “cold” tumors, thus limiting their clinical efficacy. Oncovita is developing MVdeltaC, a genetically engineered Oncolytic Virus derived from the safe measles Schwarz attenuated vaccine virus, with specific increased capacity to induce immunogenic cell death and stimulate a specific and strong immune response against cancer. With robust and promising preclinical data, Oncovita is preparing a phase 1/2a clinical study to evaluate the safety and efficacy of MVdeltaC in patients with solid tumors, including Malignant Pleural Mesothelioma and Triple Negative Breast Cancer, two aggressive and difficult-to-treat cancers. With the support of the EIC Accelerator, Oncovita will produce GMP clinical batches, prepare and conduct clinical phase 1/2a, as well as scale-up its manufacturing process to support late clinical phases.

Keywords: oncolytic virus immuno oncology triple negative breast cancer malignant pleural mesothelioma measles vaccine intra tumoral injection
Revolutionising the diagnosis of multiple Sclerosis with the first bioinformatic diagnostic kit that allows early detection with a simple blood test (ALA DIAGNOSTICS MS KIT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-02-01
End date: 2025-07-31
Duration (months): 30.0
Total project cost (EUR): 2010750.0
EU funding (EUR): 1407525.0
Participants: 1
Project status: CLOSED

Multiple Sclerosis affects around 700,000 people in Europe and 2.8 million worldwide. It is the most common chronic neurological disease in young adults in developed countries, and the main cause of disability after traffic accidents. Current diagnosis process takes one year (on average) which makes pharmacological treatment start late producing irreversible damage in patients and a worse prognosis. Combined with the high rate of misdiagnoses (20%), it leads to a healthcare cost of around €20 billion every year. ALA DIAGNOSTICS is revolutionising MS diagnosis with the first MS diagnostic kit, based on our patented recombinant protein, which is the only specific and clinically validated biomarker that exists for the diagnosis of MS in blood. Our diagnostic test is fast, easy, cheap, non-invasive, suitable for early diagnosis of MS and easy to integrate into daily clinical routine.

Keywords: multiple sclerosis,diagnosis,bioinformatics,artificial intelligence
Revolutionizing Battery Diagnostics with a novel impedance signal processing system (PerBatt)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Finland
Call: EIC Accelerator Open 2025 (HORIZON-EIC-2025-ACCELERATOR-02, 2025)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 3569647.14
EU funding (EUR): 2498753.0
Participants: 1
Project status: SIGNED

Global demand for batteries is increasing, driven largely by the imperative to reduce climate change through the electrification of mobility and the broader energy transition. Battery sales have doubled every 2-3 years over the past three decades. By 2030, sales are projected to hit 5.5-8 TWh and a value exceeding €550 billion. Current ineffective battery quality-testing is expensive, slow, inaccurate and allow only to test a small portion of production. This results in significant waste and economic loses. An average gigafactory in Europe producing up to 30% of battery scrap translates into an estimated €720 million in lost revenue annually. The inability to detect defects and predict degradation drive the need for advanced, scalable, and data-driven quality control solutions for all actor in the value chain, from manufacturing to recycling. CeLLife has developed Electrical Fingerprint Platform (EFP) technology, the world’s fastest and most accurate measurement technology for analysing, diagnosing, and grading new or used batteries at an industrial scale, regardless of battery chemistry, form factor, or type. By integrating our solution, manufacturers and recyclers can achieve significant cost savings, enhance production efficiency, ensure superior product quality and reduce up to 30% of scrap. Our prototypes have been successfully tested with world leading companies in the industry, demonstrating their effectiveness and reliability in real-world industrial settings (TRL 6). We target a lucrative market opportunity. Our TAM is estimated to reach €5.7 billion by 2030, considering the projected increase in Lithium-ion battery manufacturing and recycling capacity. CeLLife’s technology will have a huge impact on the battery industry by reducing waste, optimizing resources, and ensuring high-quality production and recycling, but also providing a substantial leap in the quality of commercially available batteries.

Keywords: battery technology,battery diagnostic methods,industrial automation
Re-exposure Effect in Bilinguals under Language Development (REBUILD)-The Acquisition of Heritage Language in Returnee Children and Mutual Effects of Experience and Cognition (REBUILD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 156778.56
EU funding (EUR): 156778.56
Participants: 1
Project status: SIGNED

Many (immigrant) children are heritage speakers (HSs; bilinguals who acquire a minority language at home, different from the majority societal language in which they are growing up). Ultimate attainment of the heritage language (HL) varies considerably amongst individual HSs—much more profoundly that what can be noted in monolingual counterparts—despite being naturalistic natives from birth. Understanding what factors explain/predict such differences in HS outcomes is a necessary first step in assessing and, ultimately, being able to meet the educational/interventional needs for bilingual HL development. Re-exposure Effect in Bilinguals Under Language Development (REBUILD) propose a novel approach that combines offline and online methods and focuses on a severely understudied, yet crucially important group of heritage speaker bilinguals, namely returnees. Returnees are children of immigrant families who spend a significant portion of their formative developmental years (school age) in a foreign majority language context, a typical HL scenario, yet return to their native HL environment, often as older children or teenagers. This research is important for the global reality in which HL bilingualism proliferates and HL returnees increase year-on-year. Examining the development of returnee’s native HL from the point of re-exposure to the native environment opens up new directions. While research shows that HL bilingualism (HLB) grammatical outcomes vary significantly, findings are largely limited to contexts in which children grow up and stay in an environment where the native HL is a minority language. Environment transitions—as in the case of returnees—open an exciting opportunity to tease apart internal (grammatical structure, non-linguistic cognitive abilities) and external factors (input, use) accounting for HLB.

Keywords: bilingualism,heritage language bilingualism,returnee,child language acquisition,executive function,eye tracking
Deconvolving sources and sinks of carbon and sulfur in magmas to reconstruct DEGASsing from Large Igneous Provinces (DEGAS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-07-01
End date: 2030-06-30
Duration (months): 60.0
Total project cost (EUR): 1999401.0
EU funding (EUR): 1999401.0
Participants: 1
Project status: SIGNED

The magnitude and consequences of future climate change depend on how Earth’s climate will respond to atmospheric chemistry alterations – vastly related to human activities. However, the complexity of the climate system makes future scenarios hard to predict. The geological record is our best source of information to constrain these scenarios by studying periods of Earth’s history during which volcanic degassing from outstanding magmatic episodes (Large Igneous Provinces, LIPs) acted as major forcing agents of climate and environmental change. Earth-system models that aim to reconstruct the global consequences of LIPs degassing proliferated in recent years, but they urgently need ground-truth gas emission data. The goal of DEGAS is to offer a new framework for obtaining these data by deconvolving sources and sinks of LIP magmatic volatiles, from the mantle source, across the crustal filter. DEGAS aims to: 1) quantify sulfur and carbon concentrations in LIPs parental magmas, hinging on the S-in-clinopyroxene method, pioneered by the PI; 2) investigate emblematic natural examples of magma-host rock interaction in volcanic basins from a within-sill perspective and with special focus on sulfur; 3) evaluate the role of the “crustal filter” as carbon and sulfur sink, with an unprecedented basin-scale approach. DEGAS investigates carbon and sulfur in LIPs magmas through multiple lenses, from the mineral to the basin-scale, in two natural laboratories, the Skagerrak-centered LIP (Oslo Rift), and the Karoo LIP. Knowing the initial volatile load and the modalities of magma-host-rock interaction is fundamental if we want to gauge the effect of the crustal filter and reconstruct source-sensitive parameters of degassing, such as isotopic signatures. DEGAS will constrain the magmatic side of the intricate volatile exchange between LIP magmas and crust, marking a fundamental step forward towards a full portrait of LIPs degassing, the only past analogue to anthropogenic emissions.

Keywords: large igneous provinces,volcanic basins,sulfur,crustal assimilation
Outcomes of plant invasions in deadwood fungi and insect communities (ENTWINE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Lithuania
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 158597.76
EU funding (EUR): 158597.76
Participants: 1
Project status: SIGNED

ENTWINE aims to understand whether and how invasive plants colonize new places, altering the structure of communities of fungus and insects linked with deadwood. The project integrates metabarcoding, phylogenetics, and community ecology to sample empirical and experimental communities that exploit native and invasive deadwood species in native and invaded forests throughout Lithuania. Exploiting long-read sequencing technologies and a bioinformatic pipeline to phase barcoding markers into Operational Taxonomic Units (OTUs), I will obtain normalised OTU richness and relative abundances and compare the β- species, phylogenetic, and functional diversity estimates between communities. Insects and fungi exploiting and living in deadwood form entwined communities that play a critical role in nutrient cycling, wood decomposition, and pathogen control. In addition to abiotic factors like local climate, biotic factors like deadwood species and decay stage influence the structure and strength of the associations with each other and their shared habitat. The abundance and quality of deadwood correlate with the local tree composition, which shifts as the invading Acer negundo spreads and outcompetes local Alnus glutinosa trees. Insect and fungi species turnover or variation in relative abundances might then result from e.g. the local extinction of rare specialists associated with A. glutinosa, the introduction of new species associated with A. negundo deadwood, and/or the increase in abundance of generalist species. Those changes in community structure resulting from A. negundo invasions may contribute to the loss of species and their ecological functions. This indicates the need to control the spread of invasive plants to prevent the extinction of vulnerable or rare species and the importance of learning the ecological roles of undiscovered species before they vanish unnoticed. ENTWINE is developed in collaboration with the Life Sciences Centre at Vilnius University, Lithuania

Keywords: metabarcoding
Closing expanding knowledge gaps in Siberian palaeo-glaciology (SIBERICE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 251578.56
EU funding (EUR): 251578.56
Participants: 1
Project status: SIGNED

Significant research efforts have been directed toward documenting glacial landform signatures for constraining the extents and chronology of past ice masses. Reconstructions show that global ice masses during the last glaciation were larger than present, lowering global sea level by ~114 m. However, ~12% of this ice contributed sea level budget is unaccounted for, suggesting that a “missing” ice mass has yet to be constrained. SIBERICE will test the hypothesis that a Siberian ice sheet existed during the last glacial, with its demise representing the unbudgeted contribution to the last glacial sea levels. To reconstruct past ice masses, I will collate landform data relating to the ice masses that glaciated Siberia and use high-resolution satellite imagery to systematically identify and map glacial landforms. This landform record will be inverted to reconstruct past ice extent and dynamics. Ice mass volumes and sea level equivalents will be calculated from the reconstructed lateral ice extents using a numerical model. I will also develop a novel method for remotely determining the age of ice margins from the morphometry of moraine ridges. To establish the moraine degradation dating curve, dimensions of chronometrically dated moraines will be systematically measured. Establishing this curve will allow the approach to be applied to remote locations around the world. The SIBERICE project at UiT will provide a prestigious platform to gain valuable training in: the leadership of large science projects; morphometric and statistical analysis of large geomorphological datasets; application of numerical models for researching the cryosphere; and teaching experience. SIBERICE targets an area of high uncertainty in palaeo-glaciology and climate change, which is highlighted as of strategic importance by scientific and governmental organisations. SIBERICE will therefore place me in a strong position to become a world leader in palaeo-glaciology and secure a faculty position.

Keywords: siberia,palaeo glaciology,glacial geomorphology,glacial inversion,sea level budget,ice sheet modelling
LEADERSHIP FOR CLIMATE RESILIENT BUILDINGS (CLIMRES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Innovation actions
Partnership: B4P (co-programmed)
Countries involved: Greece,Spain,Cyprus,United Kingdom,Italy,Netherlands,Belgium,Slovenia,Germany,France
Call: Solutions for the identification of vulnerable buildings and people-centric built environment, and for improving their resilience in disruptive events and altered conditions in a changing climate (Built4People Partnership) (HORIZON-CL5-2023-D4-02, 2023)
Start date: 2024-06-01
End date: 2027-05-31
Duration (months): 36.0
Total project cost (EUR): 5827262.5
EU funding (EUR): 4999982.5
Participants: 22
Project status: SIGNED

Europe has witnessed a significant rise in the frequency and severity of extreme weather events, and especially the broader Mediterranean region showcases the devastating consequences of climate-related disruptions. CLIMRES aims to foster a ‘Leadership foEurope has witnessed a significant rise in the frequency and severity of extreme weather events, and especially the broader Mediterranean region showcases the devastating consequences of climate-related disruptions. Unseasonably warm temperatures during the winter months are increasingly becoming a pattern, disrupting traditional weather patterns and ecosystems. CLIMRES aims to foster a ‘Leadership for Climate Resilient Buildings’, by addressing the identification and systematic categorisation of buildings’ vulnerabilities and estimating their impact in the buildings' ecosystem considering the interlinkages within the urban context. The project will deliver vulnerability assessment and impact evaluation methodologies along with an inventory hub of measures for building materials and design against climate risks and a decision support toolkit addressing three levels of decision making at strategic, tactical and operational levels. CLIMRES solutions will be tested in 3 large scale pilots in Spain, Greece, Italy and Slovenia evaluating their efficacy against heatwaves, extreme flooding, fires and earthquakes and one multi-hazard replication multiplier pilot in France. The experiences and lessons learnt from the extensive pilot evaluation will consult the replication roadmap of the project as well as a capacity building programme that will train the next frontier leaders for climate resilient buildings. Overall, the CLIMRES Leadership will provide valuable insights and guidance for building owners, policymakers, and stakeholders involved in building climate resilience and sustainable development, through the co-creation, development, deployment and demonstration at TRL 6-8 highly cost-effective and replicable solutions.

Keywords: hazards,vulnerability,sustainable materials,decision support services
Maintenance-oriented Digital Twin for Underground Infrastructure with Sensing, Machine Learning, BIM and Simulation (M-Twin4US)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 4
Project status: SIGNED

As buried pipelines face increasing maintenance challenges due to ageing, climate change, and infrastructure deterioration, failures can lead to severe economic losses and public safety risks. The M-Twin4US project aims to develop a novel, maintenance-oriented Digital Twin (DT) platform tailored for buried pipelines, with the flexibility to expand to other underground infrastructure. M-Twin4US will integrate advanced sensing technologies, Ground-Penetrating Radar (GPR) and closed-circuit television (CCTV), with state-of-the-art machine learning methods like Multi-task Transformers and Segment Anything Models (SAM). The project will address critical challenges in soil-pipe interaction analysis, GPR response prediction, and condition assessment by coupling digital modelling, machine learning, numerical modelling (hydro-mechanical and electromagnetic modelling) and real-scale testing. The project will develop a customisable surrogate model to predict future pipeline performance and offer an AI-aided toolkit for stakeholders to prioritise actions such as rehabilitation, excavation, or new construction. The project will be implemented in collaboration with key industry partners and will contribute to transforming underground infrastructure maintenance from a reactive to a proactive paradigm, supporting sustainability, safety, and resilience goals.

Keywords: underground infrastructure,digital twin,building information modelling,monitoring,maintenance,machine learning,numerical modelling
Novel nano coating process to empower the green hydrogen revolution (Naco Tech)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Latvia
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-08-01
End date: 2026-01-31
Duration (months): 30.0
Total project cost (EUR): 3333750.0
EU funding (EUR): 2333625.0
Participants: 1
Project status: SIGNED

Hydrogen is a major opportunity in the switch to an eco-friendly economy. Today, it is produced from fossil fuels with high carbon emissions. A green alternative is converting excess solar and wind energy into hydrogen via a water electrolysis process. Hydrogen produced in this process is very aggressive chemically, so electrolyser components need protection with advanced coatings. Currently, most widely used coating deposition methods are outdated and not scalable due to high production costs and usage of precious and scarce metals (e.g. of the platinum group). Naco Tech developed a breakthrough proprietary high-speed ion-plasma magnetron sputtering technology (HMS) that enables efficient application of various types of coatings. Our solution stands out with better coating quality which doubles the lifespan of electrolysers. It reduces usage on scarce metals by up to 10X, and ultimately lowers costs of green hydrogen.

Keywords: green hydrogen,nano coatings,magnetron sputtering,water electrolysis,pem membranes