Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecular characterization of the role of intra-tumor heterogeneity in cancer progression and metastasis (INTRAHETEROSEQ)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Spain
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-10-31
Duration (months): 66.0
Total project cost (EUR): 1498850.0
EU funding (EUR): 1498850.0
Participants: 1
Project status: CLOSED

Cancer is caused by somatically acquired changes in the DNA. Some of these changes fall in “cancer genes”, conferring clonal selective advantage to the cells that carry the mutant alleles. Identifying these genes/pathways is of vital importance for a correct understanding of cancer biology as well as for the diagnosis and treatment of human malignancies. In this respect, the use of genetically modified mice has been extremely useful in the past for characterizing the molecular pathways involved in cancer progression. The remarkable progress made during the last two decades on the genetic modification of mouse genomes offers unique opportunities to investigate different aspects of tumor molecular behavior, impossible to study on human samples. Recently, the advent of next-generation sequencing technologies has provided new strategies for the systematic genome-wide identification of somatic changes in cancer cell genomes. Using these technologies, we and others have characterized the high intra-tumor heterogeneity observed in some human tumors. Although the exact significance of this heterogeneity is uncertain, it seems to be responsible for key aspects in the management of cancer patients such as metastasis predisposition and tissue specificity or treatment resistance. Taking advantage of next-generation sequencing, we propose to finely characterize the intra-tumor heterogeneity evolution during the progression of tumors induced in a mouse model of pancreatic cancer, as well as, for the first time, to purify the different cell populations these primary tumors are composed of. A complete genomic and transcriptomic characterization of these populations followed by posterior functional assays will help us to identify the genes/pathways involved in tumor progression as well as metastatic potential and its tissue specificity. This new knowledge could finally contribute to a better understanding of cancer and to the design of more efficient anti-tumor therapies

Keywords: cancer molecular biology,mouse genetics
Uncovering the origin and mechanisms of Down syndrome-associated leukaemia through human induced pluripotent stem cell-derived haemopoiesis (LEUKEYOLK)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-02-01
End date: 2021-01-31
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

This project aims at dissecting the contribution of yolk sac (YS)-derived haemopoietic progenitors to childhood leukaemias, whose early onset suggests an embryonic origin. Using induced pluripotent stem cell (iPSC) differentiation, we will determine the origin of the Down syndrome-associated transient myeloproliferative disease (DS-TMD), paradigmatic example of perinatal malignancy. TMD, due to megakaryoblast hyperproliferation, has an in utero origin. This supports the compelling hypothesis of a haemopoietic stem cell (HSC)-independent origin of DS-TMD, as during embryogenesis there are at least 3 waves of progenitors with megakaryocytic potential. A first primitive program, followed by the erythromyeloid progenitors (EMP), both YS-derived and devoid of HSC potential; lastly a definitive program, generating HSCs and all haemopoietic lineages. By differentiating iPSCs from a DS-TMD patient through recapitulation of embryonic development, we will interrogate the contribution of primitive, EMP and definitive haemopoiesis to DS-TMD with in vitro/in vivo functional assays. Moreover, we will investigate the molecular mechanisms triggering the disease. As mutations leading to a short GATA1 isoform occur in all cases of DS-TMD, we will analyse how this affects the transcriptional landscape of the cells relevant to the disease. We hypothesise that DS-TMD derives from a rarely appreciated developmental program (the EMP), whose life-long contribution is only beginning to be elucidated. Determining the developmental source and mechanisms of this disorder could help designing new therapies for myeloid malignancies in non-DS patients and could lead to a paradigm shift in the field of haemopoiesis and leukaemogenesis. Research on cancer and childhood leukemias is of broad interest for the EC, as shown by the extensive funding of projects on this topic within the FP7. Our project will further nurture this research area, contributing to increasing European research competitiveness.

Keywords: human haemopoietic development,down syndrome,leukaemia,induced pluripotent stem cells,yolk sac,haemopoietic stem cells
Nuclear magnetic resonance spectroscopy of liquid-liquid phase separation (LLPS-NMR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-09-01
End date: 2024-08-31
Duration (months): 72.0
Total project cost (EUR): 2460278.0
EU funding (EUR): 2460278.0
Participants: 1
Project status: SIGNED

Liquid-liquid phase separation (LLPS) is a phenomenon inherent to the thermodynamics of liquids, is critical for the development of technologically useful fluids and underlies some of the biggest health changes in our society. LLPS is based on transitions between two different forms of liquid that have the same chemical composition, but distinct energy, entropy and density. Despite the importance of LLPS for technology and health, however, only a very low-resolution view primarily through light microscopy is currently available for LLPS states formed by peptides and proteins. Because of this bottleneck, the interactions, which stabilize liquid droplets, and regulate their biogenesis, as well as a rationale for the biochemical function of LLPS, have remained mysterious. To tackle this massive unmet need, I propose to develop powerful methods of NMR spectroscopy that go far beyond the state-of-the-art and team them up with mechanobiology/force microscopy to break the resolution barrier of polypeptide LLPS and push the description of the internal organization of liquid droplets from micrometer to sub-nanometer. Although highly challenging, the novel methods when successful will (i) disentangle the structure and kinetics of intrinsically disordered proteins within LLPS reaction chambers in space and time, (ii) unravel the nature of chemical reactions in liquid droplets, and (iii) decipher LLPS regulation by posttranslational modifications, nucleic acids and critical changes in cellular environment at atomic resolution. The innovative nature of the proposal is designed to unravel the innermost forces in liquid droplets and to transform our knowledge about the chemistry of liquid phase-separated protein states. Findings from this proposal will provide critical guidance in the development of systems to encapsulate bioactive molecules and to develop better treatments for human diseases.
Novel PDA Methodology to energize Public and Private European Energy Efficiency Projects (BundleUP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Portugal,Portugal
Call: Project Development Assistance (H2020-EE-2017-CSA-PPI, 2017)
Start date: 2018-05-01
End date: 2021-04-30
Duration (months): 36.0
Total project cost (EUR): 999437.5
EU funding (EUR): 999437.5
Participants: 8
Project status: CLOSED

Many projects of high energy savings potential, both in the private and public sectors, have been identified by building owners, local energy agencies and ESCOs. However, a large number of them consistently fails to reach implementation stage, as they collide with two main barriers: 1) lack of scale to attract professional investors in this project type and/or 2) restrictive Public Procurement procedures that are expensive to prepare and adapt to each project case. - BundleUP will develop a “Ponto Energia”, will bundle projects according to specific characteristics (investment size, technology, geography) using the currently available framework and consolidated procurement procedures to provide projects with scale, improve bankability, investor-trust and result in a faster time-to-market. The action aims at developing at least 58 Portuguese sustainable energy projects with total estimated investments of EUR 49,9m. These projects will trigger around 155 GWh/year of primary energy savings and generate 3,1 GWh/year of renewable energy. - Innovative approaches will be implemented concerning financing models and sources. BundleUP will strongly focus on energy savings projects, including renewable energy self-consumption. The project will make use of existing and innovative financing instruments, combine them with institutional investors (such as investment funds or ESCOs) while stimulating the engagement of citizens and local communities by using crowdfunding and cooperative business models to share the benefits of sustainable energy investment. - By placing Portuguese local and regional energy agencies in a central role, with regard to potential project identification, dissemination and relation with local authorities, companies and stakeholders, BundleUP will put in practice the Energy Agencies’ objective of “acting as an intermediary between the local authority and local players in the energy market.” Moreover, BundleUP will promote the replication of the developed methodology and business-models with knowledge transfer workshops aimed at sharing the knowledge gathered during the project at EU level.

Keywords: project bundling,portuguese law and regulatory framework,public buildings,solar thermal energy,solar pv electricity,public lighting,private buildings,local energy agencies,covenant of mayors
EnergyMate, the first energy efficiency-based software providing users an easy way to understand their energy consumptions (EnergyMate)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

EnergyMate, the first energy efficiency-based software providing users an easy way to understand their energy consumptions. Residential energy consumption represents the 25% of all EU energy consumption. In this context, is clear that the reduction of energy consumption in the residential sector should play an important role in energy efficiency programs and policies. Currently, energy consumers and energy utilities face various barriers that deter them from adopting energy efficiency measures: (i)Energy bills difficult to understand by energy consumers; (ii) low-optimized energy consumptions; (iii) low quality services by energy utilities, resulting in a large number of unsatisfied customers. At Energintel S.L (Asturias, Spain) we have developed a smart solution to overcome these barriers. EnergyMate provides users information about their energy consumptions in a natural language format easily understandable by users, suggesting personalized recommendations, and allowing to adapt their behavior to the hourly energy prices. It has been estimated an annual reduction of 25% in energy consumption and an increase of 30% of the customer´s satisfaction with EnergyMate. Based on the good performance of our prototypes being currently tested in Spain, we aim to optimize the software and scale-up the technology to fulfill the technical needs of different European markets. This market, depends on the roll-out of smart meters, which is expected to be 200 million by 2020. Additionally, in the first stage of commercialization EnergyMate expects to cover at least the 52% of the market for energy retailers (over 2.000 companies). This market, with such growth potential (predicted to increase at 8.1% CAGR up to 2019), could greatly benefit from our smart solution. €6.64M sales projection has been estimated for the third year. The expected Market share covered by EnergyMate, based on the number of smart meter in Europe (at least 320 millions) will be 3% by 2023.

Keywords: energy consumptions,natural language processing,gamification,big data,saas,energy utilities,smart meter,energy bills,data mining
Metals Technology in North Aegean Societies (ME.Tech.NAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 166320.0
EU funding (EUR): 166320.0
Participants: 1
Project status: CLOSED

The project involves an interdisciplinary study of mining landscapes in northern Greece and archaeological material found therein by employing modern analytical techniques (GIS, archaeometry) in order tο provide quantifiable data on the social, symbolic and economic significance of metal production in the ancient world. The project’s objective is to address three crucial research questions corresponding to different technological breakthroughs: a) the emergence and early development of copper and silver technology within the Late Neolithic/Bronze Age cultural framework (5th-2nd mill. BC), b) the introduction of iron metallurgy associated with increased connectivity between sites of the North Aegean and Anatolia around 1200-700 BC, c) the intensification of mining and extraction of gold and silver during the Archaic and Classical period (700-323 BC), triggered by the establishment of Greek colonies on the Thracian coastline. Its methodology employs interdisciplinary research tools such as archaeological finds recording, field survey, GIS data processing, sampling and archaeometric analysis of finds as well as experimental production of metals using ancient examples. The distinctive feature of this project that will expand research beyond the current state of knowledge will be re-socializing the study of metal production and subsequently to develop new multidisciplinary approaches which will have direct scientific impact on the study of ancient Greek metallurgy and society. Dissemination of the project results will be achieved through publication of scientific articles and a monograph, presentations in international conferences, organisation of a scientific workshop with invited speakers and seminars for students. Workshops for the general public featuring simulation experiments, lectures delivered at science outreach events and a dedicated website will be crucial aspects for communicating the project results more widely.

Keywords: archaeology,mining,metallurgy,colonisation,thrace
INNOADDITIVE: Innovation Challenges for Additive Manufacturing (INNOADDITIVE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Germany,Italy,Sweden
Call: Peer learning of innovation agencies (H2020-INNOSUP-2018-2019-05, 2019)
Start date: 2019-11-01
End date: 2021-04-30
Duration (months): 18.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

Significant advances in Additive Manufacturing (AM) technologies, commonly known as 3D printing, over the past decade have transformed the ways in which products are designed, developed, manufactured, and distributed. This poses new challenges for SMEs, especially in terms of becoming aware of the benefits of AM, as well as acquiring new skills and personnel. While withstanding such transformations, according to the European Commission, public innovation agencies strive at keeping the pace of SME innovation support demand, and seek opportunities to implement programmes pivoted on new approaches. At the same time, new innovation support programs leveraging on Open Innovation working models such as Innovation Prizes and hackathons (a.k.a. Innovation Challenges) has been piloted throughout Europe, gaining evidence for improving SMEs awareness of benefits of novel technologies and innovation methodologies. Project INNOADDITIVE aims at improving the knowledge and know-how of innovation agencies about successful support initiatives that proved to impact on the adoption of Additive Manufacturing technologies in SMEs. A special focus will be given to track initiatives adopting innovative and lean formats of Innovation Challenges. This will be done by tracking existing initiatives in the field (in the three partnering regions and beyond), and then sharing relevant know-how during three peer learning workshops organized by the three project partners, and targeting an audience of innovation professionals. Ultimately, the project will deliver an actionable Guide on how to design novel Innovation Challenges capable of accelerating the adoption of Additive Manufacturing technologies by SMEs.

Keywords: additive manufacturing,3d printing,computer aided engineering,sme support,small and medium sized enterprises,innovation challenges,innovation prizes,digital innovation hubs,industry 4 0
Aerial Data Collection and Analysis, and Automated Ground Intervention for Precision Farming (Flourish)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Advanced interfaces and robots: Robotics and smart spaces
Action type: Research and Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Germany,Germany,Italy,Germany,Italy,Switzerland,France,France
Call: Robotics (H2020-ICT-2014-1, 2014)
Start date: 2015-03-01
End date: 2018-08-31
Duration (months): 42.0
Total project cost (EUR): 4780047.5
EU funding (EUR): 3560870.0
Participants: 8
Project status: CLOSED

To feed a growing world population with the given amount of available farmland, we must develop new methods of sustainable farming that increase yield while reducing reliance on herbicides and pesticides. Precision agricultural techniques seek to address this challenge by monitoring key indicators of crop health and targeting treatment only to plants that need it. This is a time consuming and expensive activity and while there has been great progress on autonomous farm robots, most systems have been developed to solve only specialized tasks. This lack of flexibility poses a high risk of no return on investment for farmers. The goal of the Flourish project is to bridge the gap between the current and desired capabilities of agricultural robots by developing an adaptable robotic solution for precision farming. By combining the aerial survey capabilities of a small autonomous multi-copter Unmanned Aerial Vehicle (UAV) with a multi-purpose agricultural Unmanned Ground Vehicle, the system will be able to survey a field from the air, perform targeted intervention on the ground, and provide detailed information for decision support, all with minimal user intervention. The system can be adapted to a wide range of crops by choosing different sensors and ground treatment packages. This development requires improvements in technological abilities for safe accurate navigation within farms, coordinated multi-robot mission planning that enables large field survey even with short UAV flight times, multispectral three-dimensional mapping with high temporal and spatial resolution, ground intervention tools and techniques, data analysis tools for crop monitoring and weed detection and user interface design to support agricultural decision making. As these aspects are addressed in Flourish, the project will unlock new prospects for commercial agricultural robotics in the near future.

Keywords: remote sensing,crop health analysis,autonomous perception,planning,navigation
To understand the redox variations and interactions between hydro-, bio- and atmosphere: the power of bromine stable isotopes. (BRISOACTIONS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

The stable isotope geochemistry of chlorine (Cl) and bromine (Br) are considerably different. While most Cl isotope data are in the range from -1.21 to +0.40‰, Br isotope data are from -0.06 to +1.48‰. Interesting is that Br isotope variations are of the same magnitude as Cl isotope variations. Also Br isotope values of ancient evaporites are very positive (+0.6‰), impossible to explain from oceans with a modern isotope composition. These data are unexpected considering the small fractionation factors for Br compared to Cl. The research we propose aims at understanding these observations and developing halogen stable isotopes to study fluid transport processes in porous media. This research has a great potential to understand the history and the migration of fluids in deep porous reservoirs which are considered for geological storage of CO2, H2 and hydrocarbons. First we aim to study historical variations of Br isotope compositions in the earth's surface reservoirs. We will study Br isotope variations in ancient evaporites that reflect Br isotope ratios of the oceans at the moment they were deposited. Second to study the geochemical processes that affect Cl and Br isotope variations. Isotope fractionation during ion-filtration that has never been studied in detail. This process is important to understand subsurface fluid flow and fractionation of ions and isotopes during fluid transport. We aim at studying Cl and Br isotope variations during this process. Also redox processes have hardly been studied. Oxidation processes can increase Br isotopes values more than Cl in spite of Br's much smaller isotope fractionation factors. Third to understand our observations we will compare the data obtained during this study with the geochemical cycles of Cl and Br. This will allow us to develop future research to continue to improve our knowledge on Cl and Br isotope variations as proxies to understand chemical cycles on earth, especially in fluids in deep porous reservoirs.

Keywords: bromine,chlorine,isotopes,redox reactions,historical variation