Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Preterm Feeding Maturity Measurement and Evaluation (PREMADES)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: SME instrument
Countries involved: Türkiye
Call: New business models for inclusive, innovative and reflective societies (H2020-SMEINST-2-2016-2017, 2016)
Start date: 2017-03-01
End date: 2020-01-31
Duration (months): 35.0
Total project cost (EUR): 2081250.0
EU funding (EUR): 1456875.0
Participants: 1
Project status: CLOSED

PREMADES is a medical diagnostic device, developed to provide health care practitioners an objective yet noninvasive means for the assessment of feeding maturity, by analyzing the swallowing patterns acquired using sensors placed around their hyoid regions. It is also intended to monitor the improvements by regular measurements and analysis of feeding maturity in the preterm infants and compare past evaluations. This non-invasive design will be painless for infants and user friendly for the medical staff. Currently, in practice, doctors utilize observational, trial-and-error techniques or nursing assessment for identification of feeding skills in preterm infants, which are mostly subjective. Efforts aimed at more objective assessment techniques have focused on invasive, pressure measurement methods that can be particularly painful for infants. However, such methods are not well suited for regular and real-time monitoring of feeding maturity, thus are not preferred in practice. As a H2020 SME Phase-1 beneficiary, an intensive feasibility study, including market, profitability analyses, possible improvements required for the prototype and a work plan has been successfully prepared. PREMADES, will meet a highly important need, particularly in the neonatal medicine. The product is expected to be proper for point of care usage, marketable globally. Total available market size of our product is €716M/year. According to the results of our detailed financial feasibility study, we are planning to achieve €67M revenue creating a total of 65 new jobs at the end of the fourth year. In Phase-2, further technical improvements will be made on the prototype and intensive commercialization activities will be implemented. To ensure a successful entrance and fast penetration into the European markets, the outcomes of the Phase 1 studies will be carefully used in Phase 2, which will help in terms of the design, production and marketing procedures to be conducted in a right manner.

Keywords: neonatal,preterm infants,feeding maturity,non invasive
Investigating protective mechanisms of gut bacteria in C. elegans models of Parkinson’s disease (Gut_Fights_PD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The recent discovery that the composition of the gut microbiota can influence the symptoms of neurodegenerative diseases is a paradigm shift in how we view these conditions. In Parkinson’s disease (PD), patients frequently experience gastrointestinal symptoms years before the development of motor deficits and recent studies reveal clear alterations in the gut microbiota composition at advanced stages, which correlate with severity of their symptoms. Therefore, understanding the molecular mechanisms by which gut bacteria interact with the host to affect the nervous system may uncover novel prognostic and therapeutic strategies for neurological diseases. To address this gap of knowledge, we propose a single bacteria-worm model as a genetically tractable system to mechanistically investigate the connection between bacterial metabolites produced in the gut and neurodegeneration. Preliminary data from the lab on a protein aggregation model of PD in C. elegans, show a strong protective effect of a human probiotic bacterial species on α-synuclein aggregation, a well-established factor in Parkinson’s disease. The aim of this project is to understand the mechanisms through which the probiotic bacteria act to protect from α-syn aggregation and the nature of the response induced in the nematode. We are proposing a bidirectional strategy, manipulating genetically both players in this interaction, the bacteria and the nematode. Using a candidate molecular approach based on available data and an unbiased high-throughput analysis, we expect to elucidate new metabolic pathways employed by the bacteria to modulate protein aggregation as well as the molecular mechanisms that elicit this response in the nematode. By directly testing on various C. elegans models of PD the pharmacological effect of the discovered beneficial metabolites, we will identify specific neuroprotective compounds with future therapeutic potential.

Keywords: c elegans,gut microbiota,protein aggregation,parkinson s disease,probiotics
Isolation and characterization of mobile sRNA/target pairs in plants by using a viral protein as a probe (GeminiDECODER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,China
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-06-01
End date: 2023-06-30
Duration (months): 36.0
Total project cost (EUR): 237065.28
EU funding (EUR): 237065.28
Participants: 2
Project status: CLOSED

In plants, RNA interference (RNAi) is involved in processes ranging from development to stress responses. The core element of this regulatory mechanism, the small RNA (sRNA), has been characterized as a mobile molecule able to spread the RNAi beyond the initiation sites, acting as a cell non-autonomous process. Examples of mobile sRNAs are known: mobile small interfering RNAs (siRNAs) deriving from viruses spread throughout the plant, and are responsible for the activation of the viral silencing in uninfected tissues; other siRNAs, together with microRNAs (miRNAs), have been described to move through different cell layers, acting as morphogens; finally, some miRNAs have been shown to move through the vasculature under stress conditions, activating protective responses. Mobile sRNAs are therefore of capital importance for plant biology, and many approaches have been followed to analyze them; however, the number of mobile sRNA/target pairs fully characterized is scarce. Recently, the C4 protein from Tomato yellow leaf curl virus (TYLCV) has been shown to interfere specifically with the cell-to-cell movement of RNAi, affecting neither accumulation nor activity of the sRNAs. In this project, C4 will be used as a novel and powerful tool to isolate mobile sRNAs and their targets, under different conditions (basal vs viral infection) and in different plants (Arabidopsis and tomato), in a large scale and with unprecedented resolution. By using C4-expressing plants, out-of-location mobile sRNAs as well as increased levels of their unprocessed targets are expected to be easily detected. Thanks to this viral probe, a whole picture of the different populations of mobile sRNAs and their targets will be obtained, and the biological relevance of the most prominent candidates will be assessed. As a result, relevant new knowledge about the regulation of key biological processes in plants will be obtained, which may open new avenues for the design of more productive crops.

Keywords: rnai,silencing,mobile srna,cell to cell movement,systemic movement,sirna,mirna,tomato,tylcv,geminivirus,plant pathogen interactions,srna seq,rna seq,arabidopsis,grafting
InP on SiN Photonic Integrated circuits REalized through wafer-scale micro-transfer printing (INSPIRE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Ireland,Belgium,France,Czechia,Netherlands,United Kingdom
Call: Advancing photonics technologies and application driven photonics components and the innovation ecosystem (H2020-ICT-2020-2, 2020)
Start date: 2021-01-01
End date: 2024-06-30
Duration (months): 42.0
Total project cost (EUR): 4982281.75
EU funding (EUR): 4982281.75
Participants: 7
Project status: SIGNED

INSPIRE aims to revolutionize photonic integrated circuit technology by combining two technologies, InP photonics and SiN photonics, in a single platform through wafer-scale micro-transfer printing technology. This platform will allow to combine high-performance III-V opto-electronic components (semiconductor optical amplifiers, high-speed phase modulators and photodetectors) operating in the C-band with the high-performance passive functionality of the SiN platform (high performance filters, 5dB/m waveguide loss), on 200mm wafers. The micro-transfer printing integration approach enables high-throughput integration of III-V devices on SiN photonic integrated circuits with better than 1 um alignment accuracy, resulting in high-performance, low-cost photonic integrated circuits. While being applicable in a wide range of mega-markets, the INSPIRE technology will be validated by three use cases: the case of a distributed fiber sensing readout unit based, the case of a microwave photonics RF pulse generator and a datacenter switch fabric. Compact models of the III-V opto-electronic components will be developed enabling designers to exploit this platform for a wide range of applications. INSPIRE will sustain Europe’s industrial leadership in photonics by combining the generic integrated foundry technology at the pioneering pure-play foundry SmartPhotonics, and the silicon photonics pioneer IMEC, with the micro-transfer printing technology at X-Celeprint, making this a world-first platform combining the strengths of all known PIC manufacturing platforms. It will also strengthen the European manufacturing base by developing and implementing processing steps that are key to removing expensive assembly steps in photonic IC based product realization. The methods will be developed for silicon nitride – indium phosphide integration. Since the optical coupling happens through a silicon intermediate layer the developed technology can be ported to silicon CMOS photonics as well.

Keywords: indium phosphide,silicon photonic,hybrid platform,micro transfer printing
Effective Equations for Fermionic Systems (EFFECT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-01
End date: 2023-11-15
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

The goal of this project is to substantially improve the understanding of the non-equilibrium dynamics of large fermionic systems and their interaction with the quantized electromagnetic field. Fermionic systems play a significant role in the description of molecules and condensed matter. Their time evolution is determined by the Schrödinger equation which, however, is very challenging to analyze for large systems with many particles. For this reason simpler effective equations are used to approximately predict the time evolution. These are easier to investigate but less exact. In physics, effective equations are derived by heuristic arguments. Beyond that, a mathematical analysis is essential to prove the range of validity of the applied approximation. In the scope of this project new mathematical tools will be developed to rigorously derive effective evolution equations for fermionic systems at zero and finite temperature. The Hartree-Fock equation with Coulomb potential will be derived from the Schrödinger equation in a many-fermion mean-field limit which is coupled to a semiclassical limit. In the same scaling limit the use of the (fermionic) Maxwell-Schrödinger equations as approximate time evolution of the Pauli-Fierz Hamiltonian will be justified. Moreover, it will be proven that the quantum fluctuations around the effective equations are described by Bogoliubov theory. Explicit estimates for the error caused by the approximation will be provided. In total, this will enhance the understanding about the creation of correlations among fermions and the emergence of classical field theories from quantum field theories. The derivations are long outstanding and there is an extensive need for new mathematical methods in semiclassical analysis and many-body quantum mechanics. It is expected that the new techniques will also have a strong impact on studies about dilute Bose gases at positive temperature and fermionic systems in the kinetic regime.

Keywords: many body quantum mechanics,effective evolution equations,mean field limit,hartree fock equation,maxwell schr dinger equations,fermionic systems,pauli fierz hamiltonian
lOw Power heterogeneous architecture for nExt generation of smaRt infrastructure and platforms in industrial and societal Applications (OPERA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Israel,Italy,Italy,France,France,France,Netherlands,United Kingdom
Call: Customised and low power computing (H2020-ICT-2015, 2015)
Start date: 2015-12-01
End date: 2018-11-30
Duration (months): 36.0
Total project cost (EUR): 6502496.25
EU funding (EUR): 6502496.25
Participants: 12
Project status: CLOSED

OPERA project aims at supporting these ambitious challenges with technological innovation on three main aspects: • Design next generation Low Power (LP) and Ultra-Low Power (ULP) systems, • improve energy efficiency in computing by means of heterogeneous architectures, • and provide smart and energy efficient solution for the interaction between embedded smart systems and remote small form-factor data centers OPERA project fits into the mission and scope of the H2020 ICT workplan for 2014 and 2015 aspiring to the European leadership in industrial technologies for the Ultra-Low Power computing devices and sensors enabling an ecosystem of heterogeneous devices and small form factor data centers In this context, OPERA’s vision is to deliver innovation on highly parallel, heterogeneous, reliable, low power, and secure systems leveraging both low power server-class processors and reconfigurable devices. While the former provide energy efficient processing power for the majority of the workloads, the latter offer the possibility of customizing and adapting hardware solutions over time to specific needs. The targets of innovation in OPERA are next generation LP servers and highly parallel embedded computer systems based on ULP architectures. Adopting a mechanism for selecting the best processing element for a specific task is fundamental for achieving good levels in energy efficiency. OPERA aims at exploiting such kind of mechanisms to orchestrate both general-purpose and reconfigurable devices. The OPERA vision is to integrate ULP smart devices into a platform that uses next-generation LP servers to remotely process the data and offering cloud-based services. OPERA's added value to the project is the validation of the technological solutions on three different real-life workloads use-cases. By integrating and optimizing computing systems for energy efficiency at different levels of the computing continuum, OPERA envisages the creation of big opportunities for Europe

Keywords: 3d integrated circuits,ultra low power computing platforms,heterogeneous systems,reconfigurable devices,fpgas,high density mini servers
Making Wind Energy More Bankable…Faster! (ZephyCloud)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: France
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-07-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

At Meteopole we set our sights on making the wind energy sector more profitable by maximising the economic value of the wind energy site through optimising wind “quality” and “quantity” and de-risking market and performance uncertainties. Meteopole specialising in wind power optimisation. We realised there was a need in the wind energy sector to provide both technical and technological expertise to an industry suffering from a lack of confidence and reliability. Our ZephyWDG (Wind Data Generator) and ZephyCDF (Computational Fluid Dynamics) products are currently sold as desktop packages to utility companies, Green Field developers, consultancies, certification bodies and research institutions and banks. These analytical tools reduce uncertainties at each and every stage of a wind project development to ensure that a wind farm project (onshore and offshore) deployment will be profitable with optimum power performance for all key players mentioned. These industry-proven tools also rectify and optimise performance on existing wind energy projects. However, these tools, in their current format as desktop packages are holding us back and do not give us the benefits of being on the Cloud. This is why need this Phase 1 to carry out a feasibility study and draft a business plan to be full our ambitions to our platform and tools on the Cloud (to offer it as a SaaS to scale-up our products and offer it as a worldwide service, to offer the platform as Opensource, and to be able to analyse and gather big data to for our customers to be use when analysing and evaluating similar “case studies”). We will also define a pricing strategy for our 3 types of users (free users who pay for what they calculate), active users who pay an annual fee and also get premium services and academic users). Together with our know-how, products and service and this Phase 1, we will de-risk the wind energy market to make wind energy a force to be reckoned with!

Keywords: profitability,reliability,cloud,platform,investor confidence,faster results,optimization,power,performance,market de risk,opensource,beta version,forecast revenue,big data
Magnetic approaches for Tissue Mechanics and Engineering (MaTissE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-07-01
End date: 2020-12-31
Duration (months): 66.0
Total project cost (EUR): 1589000.0
EU funding (EUR): 1589000.0
Participants: 3
Project status: CLOSED

While magnetic nanomaterials are increasingly used as clinical agents for imaging and therapy, their use as a tool for tissue engineering opens up challenging perspectives that have rarely been explored. Lying at the interface between biophysics and nanomedicine, and based on magnetic techniques, the proposed project aims to magnetically design functional tissues and to explore the tissular fate of nanomaterials. Magnetic nanoparticles will be safely introduced into therapeutic cells, thus allowing them to be remotely manipulated by external magnets. 3D manipulations of the magnetized cells (patented in 2012) will be used to form tissues with a controlled size and shape through the development of a unique magnetic bioreactor. In a self-integrating all-in-one process, 3D tissue will be shaped from cellular "bricks" without the need for a scaffold. The magnetic tissue will be amenable to mechanical stimulation and in situ imaging at each step of its maturation. The project is inherently multidisciplinary: 1) From a biophysics standpoint, controlled tissue stimulation, forced cell alignment, and mapping of cell-cell forces, will be used to answer pressing questions on the role of physical stresses in cell and tissue functions, such as differentiation. 2) From a regenerative medicine standpoint, this magnetic technology will be applied to cartilage and cardiac tissue repair. The functionality of the constructs and their centimetric size range, combined with a surgeon-friendly tissue handling with a dedicated magnetic tool, and the inherent magnetic resonance imaging properties of the constructs will be major advantages for clinical translation. 3) From a nanomaterials standpoint, nanomaterial fate will be explored in situ using nanomagnetic methods, both at the tissue scale (macroscopic) and at the nanoscale. This is a necessary corollary for the use of nanomaterials in regenerative medicine, and one that is largely unexplored.

Keywords: nanomagnetism,iron oxide nanoparticles,nanobiodegradation,nanomedicine,magnetic manipulation,tissue engineering,stem cells,tissue mechanics
Innovative dual cycle tracking system for contraception and conception on a single device (ILO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Women usually track their menstrual cycle for three main reasons: As a natural contraceptive tool, to increase the chances of conceiving or for health-related reasons. However, monitoring every stage of the cycle in an accurate manner has proven challenging, due to the many variables influencing its progression (e.g. irregular periods, stress, etc.). Currently, there are two main approached to cycle tracking: Cycle tracking devices (which represent the old-fashioned approach, fairly reliable but require self-assessment and expertise to get accuracy), and “cutting edge” app-based cycle tracking methods (which are user-friendly, but rely in subjective facts related to the period - e.g. length or amount of bleeding-, traditional measurements -e.g. core body temperature- and algorithms, and lack accuracy. Hence, none of these approaches fulfils the “golden” criteria of being reliable, precise, simple and non-invasive. At Carbomed, we strive to overcome the limitations of both approaches thanks to our innovative ILO system, the seamlessly combination of a handheld device and an app, that reliably predicts the time of ovulation by relying on a scientifically-based method: Measuring the CO2 levels from exhaled air. ILO conveys the best features from both approaches, being accurate, simple and non-invasive while providing a user-friendly experience thanks to our bespoke app. ILO can be used as a dual cycle tracking device predicting the most fertile window, as a natural contraceptive method, but also as a tracking device for those who want to get pregnant. For Carbomed, ILO represents a large business opportunity, aimed initially at the child wish market and subsequently (and most importantly) at the contraception market valued at €17.6 billion back in 2016. In this way, we expect to sell 180,500 ILO units in the first three years of commercialization, reaching cumulative profits of €23.39 million by 2023. To reach this goal, we will increase our staff count by 700%.

Keywords: cycle tracking,ovulation,respiration,simple,convenient