Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Hydrogen-Methanol Ship propulsion system using on-board pre-combustion carbon capture (HyMethShip)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: Innovation actions
Countries involved: Austria,Austria,Austria,Germany,Germany,Germany,Austria,Sweden,Belgium,Netherlands,United Kingdom
Call: Innovations for energy efficiency and emission control in waterborne transport (H2020-MG-2017-Two-Stages, 2017)
Start date: 2018-07-01
End date: 2021-12-31
Duration (months): 42.0
Total project cost (EUR): 9288310.0
EU funding (EUR): 8438110.0
Participants: 15
Project status: CLOSED

The HyMethShip project reduces drastically emissions and improves the efficiency of waterborne transport at the same time. This system will be developed, validated, and demonstrated on shore with a typical engine for marine applications in the range of 2 MW (TRL 6). The HyMethShip system will achieve a reduction in CO2 of more than 97% and will practically eliminate SOx and PM emissions. NOx emissions will be reduced by more than 80%, significantly below the IMO Tier III limit. The energy efficiency of the HyMethShip system is more than 45% better than the best available technology approach (renewable methanol as fuel coupled with conventional post-combustion carbon capturing). The HyMethShip system innovatively combines a membrane reactor, a CO2 capture system, a storage system for CO2 and methanol as well as a hydrogen-fueled combustion engine into one system. The proposed solution reforms methanol to hydrogen, which is then burned in a conventional reciprocating engine that has been upgraded to burn multiple fuel types and specially optimized for hydrogen use. The HyMethShip project will undertake risk and safety assessments to ensure that the system fulfills safety requirements for on-board use. It will also take into account the rules and regulations under development for low flashpoint fuels. The cost effectiveness of the system will be assessed for different ship types and operational cases. For medium and long distance waterborne transport, the HyMethShip concept is considered the best approach available that achieves this level of CO2 reduction and is economically feasible. The HyMethShip consortium includes a globally operating shipping company, a major shipyard, a ship classification society, research institutes and universities, and equipment manufacturers. Further stakeholders will be represented in the External Expert Advisory Board and will be addressed by dissemination activities respectively.

Keywords: maritime on board ccs system,hydrogen ic engine,methanol energy carrier,methanol reformer,waste heat recovery
voCAL articuLations Of Parliamentary Identity and Empire (CALLIOPE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Finland
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2023-02-28
Duration (months): 60.0
Total project cost (EUR): 1499905.0
EU funding (EUR): 1499905.0
Participants: 1
Project status: SIGNED

What did politicians sound like before they were on the radio and television? The fascination with politicians’ vocal characteristics and quirks is often connected to the rise of audio-visual media. But in the age of the printed press, political representatives also had to ‘speak well’ – without recourse to amplification. Historians and linguists have provided sophisticated understandings of the discursive and aesthetic aspects of politicians’ language, but have largely ignored the importance of the acoustic character of their speech. CALLIOPE studies how vocal performances in parliament have influenced the course of political careers and political decision making in the 19th century. It shows how politicians’ voices helped to define the diverse identities they articulated. In viewing parliament through the lens of audibility, the project offers a new perspective on political representation by reframing how authority was embodied (through performances that were heard, rather than seen). It does so for the Second Chamber in Britain and France, and in dialogue with ‘colonial’ modes of speech in Kolkata and Algiers, which, we argue, exerted considerable influence on European vocal culture. The project devises an innovative methodological approach to include the sound of the human voice in studies of the past that precede acoustic recording. Adapting methods developed in sound studies and combining them with the tools of political history, the project proposes a new way to analyse parliamentary reporting, while also drawing on a variety of sources that are rarely connected to the history of politics. The main source material for the study comprise transcripts of parliamentary speech (official reports and renditions by journalists). However, the project also mobilizes educational, satirical and fictional sources to elucidate the convoluted processes that led to the cultivation, exertion, reception and evaluation of a voice ‘fit’ for nineteenth-century politics.

Keywords: voice,rhetoric,political culture
Compliant Actuation Robotic Platform for Flexible Endoscopy (CARPE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-07-01
End date: 2016-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Prof Alfred Cuschieri, the overall coordinator of ERC grant Colonic Disease Investigation by Robotic Hydro-colonoscopy (CODIR - grant agreement 268519) has recently submitted the mid-term scientific report on behalf of the two participating Universities (Dundee and Leeds), which highlights several novel IPR (intellectual property rights) issues resulting from the CODIR research, which are pertinent to robotic flexible endoscopy. One of these is based on the ‘active tether robot’ (ATR) idea for the provision of snake like locomotion; i.e., instead of the locomotive power for the active colonoscope being supplied to the back of the robot via a power cable, the design is turned on its head, and replaced by a motile segmented ‘active tether’, which is itself an endoscope, and which can operate in both a gas and aqueous environment. The platform is based on a Mini Compliant Joint (MCJ), with two degree of freedoms (DoFs) using Shape Memory Alloy (SMA) wires as actuators and torsional springs, a synergistic combination which increases the energy efficiency and mechanical bandwidth performance; and at the same time, reduces heat production and stress on the SMA wires. The MJCs actuates by current-induced contraction of SMA wires, two hollow articulating rings with 2 DoFs. As the rings have intersecting axes, the two torsional springs provide roll and pitch. Such a chain of active MCJs provides sinusoidal motor-less locomotion. In essence, CARPE is a generic modular system (capable of translation into any type of flexible endoscope in current clinical use) consisting of independent segments (much like a biomimetic vertebral column), mechanics and electronics. The big advance of CARPE, when used to construct a colonoscope over the current equivalent endoscope, is that once, the end of the CARPE colonoscope is inserted through the anus, it would travel by its intrinsic snake-like locomotion to the caecum.

Keywords: flexible endoscopy,compliant actuators,active endoscopes,mini robots,enteroscopy
A next generation medical device that enhances patient care and treatment following colorectal surgery (CG-100)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: SME instrument
Countries involved: Israel
Call: Supporting innovative SMEs in the healthcare biotechnology sector (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-03-01
End date: 2017-06-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cologuard Ltd is a clinical stage medical device company founded in Dec 2010. Cologuard's novel and proprietary technology for colorectal surgery was developed in order to prevent the profound clinical and economic pains associated with anastomotic leaks and diverting colonic stomas. Anastomotic leakage (AL) is a life threatening complication, which can occur following colorectal surgery for colorectal cancer or other diseases. In order to prevent AL, surgeons use a procedure called diverting stoma, which result in an ostomy bag for external bypass of waste. This solution leads to a low quality of life for patients, causing many clinical complications, including sepsis, parastomal hernia, ulcers, chronic depression and skin infections. In addition, this procedure has a high economic cost for the patient and the healthcare system. The Cologuard team have developed the CG-100, a single use intraluminal device composed of silicon, which functions as an internal bypass for colonic content, reducing contact between faecal content and the anastomosis site. The device allows healing to take place without the need for an external diverting stoma and ostomy bag. The CG-100 device improves patient care through the reduction of risky complications associated with ostomy bags, improving the healing process and providing a better quality of life. Healthcare costs will be greatly reduced by up to 50%. The company is composed of a strong team comprising top doctors and medical advisors as well as entrepreneurs with vast experience in the medical device sector. The company received CE mark for its lead product in 2014 and is confidently moving towards pre-marketing clinical trials in the EU. Cologuard has received over 4.2 M EUR funding to date. The company is headquartered in Israel and employ 5 full time employees and multiple subcontractors. The company is currently in talks with companies in the EU who have shown an active interest in the project.

Keywords: cancer,colon cancer,surgical device,medical device,ostomy bag,anastomotic leakage
Multilevel Selection for Specificity and Divergence in Bacteria (MultiLevelLandscape)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Israel
Call: ERC Consolidator Grant (ERC-2016-COG, 2016)
Start date: 2017-03-01
End date: 2023-02-28
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: CLOSED

The evolution of specificity between interacting biological molecules underlies the diversification and expansion of biological pathways. A shift in specificity poses a serious theoretical problem; it requires coordinated mutations in the interacting partners, but mutation in one partner may lead to loss of interaction and functional failure. While some theoretical suggestions were proposed to solve this 'specificity valley crossing' problem, it remains a challenge to study this problem empirically at the molecular level. In bacteria, there are numerous divergent evolving pathways. Many of these pathways are involved in mediating conflicts between selfish genes, cells and populations. We and others have speculated that such multilevel selection can facilitate pathway divergence. Here we propose to study this link using the Rap-Phr cell-cell communication system, which has diversified to ~100 specific systems in the B. subtilis lineage. These systems consist of a receptor (Rap) and its cognate peptide pheromone (Phr) that influence multiple levels of selection. They promote their own horizontal transfer, modulate core cellular pathways, and manipulate cooperation between cells. Combining modelling with deep mutational scanning, competition assays and time-lapse microscopy we will quantitatively study all these levels of selection and their implication for diversification on a large fitness landscape. Specifically, we will (1) map the Rap-Phr interaction landscape at unprecedented resolution, constructing and screening libraries of ~106 Phr peptide variants and ~104 Rap variants. (2) Quantify the fitness effects of these systems at multiple levels of selection in biofilms. (3) Theoretically generate and experimentally verify predictions about how Rap-Phr co-evolve and diversify. Our work will pioneer the study of fitness landscapes under multilevel selection and provide a direct, quantitative, and predictive framework for understanding the evolution of specificity.

Keywords: multi level selection,social evolution,fitness landscapes,diversification,microbial systems biology,microbial development,biofilms,quorum sensing,mobile genetic elements,protein interactions
Adaptive Neuro Care System (Neuro Care System)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Hungary
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2016-10-31
Duration (months): 3.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The objective of the overall innovation project is the development and introduction of a medical instrument family and telemetric solution built on mobile information-technology basis. The currently known potential application areas include the diagnostics and treatment of the most common symptoms of Parkinson’s disease, essential tremor and dystonia, and the support of implementation of therapeutic goals-related symptomatic treatment. According to OECD, the economic and social impact of chronic brain disorders will be the number one public-health problem worldwide, affecting 100 million people by 2050. From the perspective of society, this is the most expensive disease group. The diagnostics of the typical symptoms of neuro-degenerative diseases is only partially objective at present, as in many respects it is based on the personal conclusions of the patient. The large scale dissemination of the envisaged innovation may prove to be a significant leap forward in resolving these issues. The large number of people concerned, the elevated expenses of their care, and the aging trend typical of developed societies may in the long run result in a major business opportunity and at the same time a serious growth potential for the enterprise. The innovation Neuro Care is built on invasive technology and offers a new, adaptive therapeutic procedure for patients showing advanced symptoms. In addition this system ensures simultaneous telemetric condition monitoring for a large number of patients and their specialists without the need of physical contact between them. The desired achievement of the Phase 1 is the elaboration of a Feasibility Study containing: Market Analysis, Business Plan, Marketing Plan, Legal and Organization Plan, Technological Plan.

Keywords: intelligent implant,treatment supervision,adaptive stimulation therapy,remote health services,telemedicine,drug protocol optimization,cloud service,wireless recharging methods,tremor
A Global Anthropology of Transforming Marriage (AGATM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 2297584.0
EU funding (EUR): 2297584.0
Participants: 1
Project status: SIGNED

This research will create a new theoretical vision of the importance of marriage as an agent of transformation in human sociality. Marriage globally is undergoing profound change, provoking intense debate and anxiety. These concerns refract wider instabilities in political, economic, and familial institutions. They signal the critical role of marriage in bringing together - and separating - intimate, personal, and familial life with wider state institutions. But we have little up to date comparative research or general theory of how marriage changes or the long-term significance of such change. Paradoxically, social scientific and public discourse emphasise the conservative and normative aspects of marriage. This underlines the need for a new theoretical frame that takes account of cultural and historical specificity to grasp the importance of marriage as both vehicle of and engine for transformation. AGATM overturns conventional understandings by viewing marriage as inherently transformative, indeed at the heart of social and cultural change. The research will investigate current transformations of marriage in two distinct senses. First, it will undertake an ethnographic investigation of new forms of marriage in selected sites in Europe, N. America, Asia, and Africa. Second, it will subject ‘marriage’ to a rigorous theoretical critique that will denaturalise marriage and reintegrate it into the new anthropology of kinship. Research on five complementary and contrastive sub-projects examining emerging forms of marriage in different locations will be structured through the themes of care, property, and ritual forms. The overarching analytic of temporality will frame the theoretical vision of the research and connect the themes. The resulting six monographs, journal articles, and exhibition will together revitalise the study of kinship by placing the moral, practical, political, and imaginative significance of marriage over time at its centre.

Keywords: marriage,social transformation
MinWaterCSP - Minimized water consumption in CSP plants (MinWaterCSP)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Italy,South Africa,Germany,Germany,Germany,Germany,Spain,Italy,Belgium,Morocco
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2015-1-two-stage, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 5861371.75
EU funding (EUR): 5861371.75
Participants: 14
Project status: CLOSED

MinWaterCSP addresses the challenge of significantly reducing the water consumption of CSP plants while maintaining their overall efficiency. Its objective is to reduce evaporation losses and mirror cleaning water usage for small- and large-scale CSP plants through a holistic combination of next generation technologies in the fields of i) hybrid dry/wet cooling systems ii) wire structure heat transfer surfaces iii) axial flow fans iv) mirror cleaning techniques and v) optimized water management. MinWaterCSP will reduce water evaporation losses by 75 to 95% compared to wet cooling systems. It aims to increase the net efficiency of the steam Rankine cycle by 2%, or alternatively reduce the capital cost of a dry-cooling system by 25%, while maintaining cycle efficiency. To complement this, mirror cleaning water consumption will be reduced by 25% through an improved mirror cleaning process for parabolic trough collectors, the development of a cleaning robot for linear Fresnel collectors and a reduced number of cleaning cycles enabled by an enhanced monitoring of the reflectance of the mirrors. Also, comprehensive water management plans for CSP plants in various locations will be developed and combined with plant performance simulations to maximize the impact of the achieved design improvements in a complete system context. Zero liquid discharge and the option of making use of solar energy or low grade waste heat for water treatment will be considered. MinWaterCSP will improve the cost-competitiveness of CSP. This will make CSP more attractive for investment purposes and drives growth in the CSP plant business as well as job creation at European companies which provide technologically advanced CSP plant components. In addition, by making CSP technology more attractive MinWaterCSP contributes to solve the global climate challenge by reducing carbon-dioxide emissions and increasing energy generation from renewable resources.

Keywords: increase of electrical efficiency of a csp plant,reduction of water usage during mirror cleaning,usage of dry and hybrid dry,wet cooling systems,improved cost benefit ratio of csp
Organ-on-a-chip Drug screenIng device to tArget braiN diseAse (DIANA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-11-01
End date: 2022-04-30
Duration (months): 18.0
Total project cost (EUR): 171428.57
EU funding (EUR): 100000.0
Participants: 2
Project status: CLOSED

The commitment to drug development for brain pathologies is experiencing a fast rate decreasing, a critical situation in a worldwide scenario where the number of patients affected by brain pathologies like Alzheimer’s (AD) or Parkinson’s (PD) disease are expected to greatly increase in the next decades. One critical point is that the development of new drugs is a three-phase process that currently requires 10-15 years and investment of 1-3 billion euros against a failure rate of about 99.6% for AD new drugs. The reasons of this discouraging scenario are multifaceted, but an important percentage of failure depends on weak quality of biological target validation assays, mainly due to the presence of the blood-brain barrier and the complexity of brain physiology that make challenging brain disease modelling. Hence, it is particularly crucial to implement an innovative, reliable in vitro cell model able to predict the potential of a new drug to cross the blood-brain barrier and effectively target the brain. DIANA (Organ-on-a-chip Drug screenIng device to tArget braiN disease) project aims to perform the technical and commercial feasibility of the integrated stand-alone BBB-brain model in-vitro, Chip4D Brain, based on patented organ on chip technology, providing the basis for a new generation of innovative devices. DIANA will be run by a consortium between Politecnico di Milano and an industrial partner, Neuro-Zone srl (Contract Research Organization – CRO - specialized in R&D for drug development in brain diseases for pharma) combining a solid technological expertise and an in-depth knowledge of the market.

Keywords: bioengineering,drug screening,in vitro cell model,organ on a chip,miniaturization