Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Clarifying role of the CENTROSOME in abnormal mitotic processes featuring the most common childhood malignancy: paediatric High Hyperdiploid Acute Lymphoblastic Leukaemia (HHDpALL) (CENTR-ALL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-24
End date: 2021-01-23
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Paediatric Acute Lymphoblastic Leukaemia (pALL) still accounts for most cancer-related deaths in children. Although high hyperdiploidy (HHD) is the most frequent pattern, its pathomechanism remains poorly understood. Recently, Experienced Researcher (ER) et al showed that sequential chromosomal gains and chromosomal instability (CIN) are critical features in HHD-pALL evolvement. The most common cause of CIN is centrosome amplification (CA) and recent findings indicate that inhibiting centrosome clustering (mechanism by which tumour cells control CA to retain viability) is a promising therapeutic avenue. Opposed to most solid and hematologic malignancies, the role of CA in HHDpALL has not been clarified thus far. Primary goal of ER is to illuminate this issue, which is expected to result in new diagnostic- and screening methodologies, as well as novel therapeutics. ER will join a leading group in the field of ‘cancer associated centrosome abnormalities’ (headed by Professor Alwin Krämer), in one of Europe’s largest cancer research institutes (DKFZ, Germany), applying state-of the art technologies in genomics and functional cell biology. Centrosomes are mostly visualized by immunocytochemistry, but precise evaluation is error prone and featured with inter-personal/-laboratory variance. A diagnostic and high-throughput screening methodology thus is highly desirable. Accordingly, second aim is to develop a novel automated fluorescence light microscopy (aFLM) application for centrosome analysis, building on ER's previous experience, but in a cross-sector collaboration with a non-academic world leader in image analysis (MetaSystems, Germany). To gain ultrastructural information as well, ER will also align aFLM with scanning electron microscopy for the first time, in collaboration with the Schwab Group (EMBL, Germany) creating high-capacity correlative light electron microscopy (hcCLEM). Commercial potentials of above original developments will also be investigated.

Keywords: childhood acute lymphoblastic leukaemia,chromosomal instability,centrosome aberration,automated microscopy,high throughput image analysis,clem
Anticancer activity of plasma activated medium and its underlying mechanisms: Combined experimental and computational study (Anticancer-PAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

Cold atmospheric plasma (CAP) is gaining increasing interest for cancer treatment, although the application is still in its early stages. Besides direct CAP treatment of cancer cells, plasma can also be used to activate a liquid medium, which seems to have similar anti-cancer effects as the plasma itself. This so-called plasma activated medium (PAM) is very promising for cancer treatment, as it can be more generally used, e.g., it might be directly injected into tissue of patients. However, the anticancer potential of PAM is not yet fully understood. This is exactly the focus of this project. We will measure the reactive oxygen and nitrogen species (RONS) concentrations in PAM, and also calculate them with a model for plasma-liquid interaction. In addition, we will study the effect of PAM on a catalase model protein by experiments, and perform atomic scale simulations for the interaction of RONS with this protein, to better understand the effect of PAM on cancer cells, because catalase aids cancer cells in overcoming oxidative stress created by PAM.

Keywords: plasma chemistry,plasma medicine,cold atmospheric plasma,plasma liquid interaction,molecular dynamics simulations,plasma for cancer treatment
high-performance BIOPLAStic PROducts for new markets and applications (BIOPLAS-PRO)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-04-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Environmental awareness, limited oil reserves and EU legislations are driving the need for eco-friendly alternatives to synthetic plastics. In this context, we present BIOPLAS-PRO, project aiming at developing and commercializing high-performance and cost-effective bioplastic products for the civil and advanced composite industry that contain more than 95% of starch-based biopolymers, are 100% eco-friendly, recyclable and O-degradable. Envisioned products include BIO-MAT and BIO-DRAIN, 3D structured mats for soil stabilization, erosion control and water drainage control, and BIO-CORE, a 2D/3D structured spacer and resin flow media used in composite products. Our products are produced by our unique isotropic extrusion-moulding process ensuring the best biopolymer processing conditions and highest quality products. We are the first company in the world to have successfully adapted this extrusion-moulding process to bioplastics. The Phase I feasibility study is required to set-up detailed product and production scale-up requirements and ensure the overall commercial viability of the project. The end users of our products are construction companies and enterprises manufacturing composite products. Their needs are high quality products and low environmental impacts. Our products provide similar or better performance to existing synthetic and/or natural solutions, are made 100% from renewable resources and have controlled biodegradability (100% degradation in 1-5 years). Within the first 5 years, we estimate to sell 13 kton of products, which will generate €30 million of accumulated revenues while reducing plastic waste by 10 kton and CO2 emission by 32 kton. This is perfectly in-line with EU strategies on reducing the use of harmful materials and improving waste management.

Keywords: biopolymer,bioplastic,extrusion process,synthetic plastics,bio degradable,isotropic extrusion,extrusion moulding,environment,bio economy
Rise of the 3rd dimension in nanotemperature mapping (ThermoRise)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Portugal
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1988353.75
EU funding (EUR): 1988353.75
Participants: 1
Project status: SIGNED

The last decades witnessed a quest for devices responding to temperature at a distance with unprecedented space resolution, approaching the nanoscale. Such devices are valuable in both fundamental and applied science, from overheat in micromachines to hyperthermia applied to cells. Despite great advances, the response is still collected in 2D. In real systems, heat flows in 3 dimensions such that 2D nanothermometers give just a plane view of a 3D reality. The restriction to 2D emerges because space resolution is bound to time and temperature resolutions, leading to a trilemma: scanning into the 3rd dimension is time consuming and cannot be achieve without losing temperature and time resolutions. While incremental improvements have been achieved in recent years, adding the 3rd dimension to nanothermometry is crucial for further impact and requires an innovative approach. Herein, I propose the development of nano local probes with tailored magnetic properties recording critical information about local temperature in 3D. These thermometric local probes avoid the resolution trilemma by recording the most relevant temperature information instead of reading the present temperature value. In many applications, including cellular hyperthermia, most part of the current temperature reading is of minor relevance and can be dropped. The key temperature information includes the maximum temperature achieved, the surpass of a given temperature threshold, and the time elapsed after this surpass. Once recorded, this key information can be read in 3D by standard devices (such as confocal microscopes and magnetic resonance imaging scanners) without time constrains and thus keeping a high space and temperature resolution. Moreover, the reading step can be performed in-situ and/or ex-situ, decoupling probes and reading devices if needed. This widens the range of applications of nanothermometers, allowing detection in confined environments and in non-transparent media.

Keywords: magnetic nanoparticles,nanothermometers
TRIDENT ELASTIC HSM PLATFORM (TRIDENT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Hungary
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2020-01-01
End date: 2020-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Although the use of encryption in the business is increasing, most of the data are still stored unencrypted. Companies apply improved security measures but still suffer from cyberattacks and data breaches. Even though hardware security modules (HSM) are the most secure options in cryptographic processing and key management, they are expensive, and their usage is limited to large entities. I4P Ltd. has developed the world’s first multi-party HSM module, which can distribute encryption keys on several devices, thus significantly reducing the security risk. Built on this HSM, I4P develops a scalable cloud-based system (TRIDENT ELASTIC HSM PLATFORM), which offers the most comprehensive crypto security services even for users with a single, entry-level HSM device. Trident platform competes both with the HSM manufacturers (e.g., Thales, nCipher, Utimaco) and the cryptographic service providers (e.g. Google, Microsoft). However, it is well-positioned with the multi-party HSM-based unique service offerings, such as the on-demand performance increase or capacity renting. Besides the large enterprises and organizations, the Trident Platform will be a perfect solution for the more cost-sensitive SMEs. Although HSM-BASED SOLUTIONS are still considered a niche market, it is one of the fastest-growing IT market segments with a CAGR of 10.9%, and an expected 1 billion volume by 2022. The use of HSM is expected to double within the next 12 months. The REVENUE comes from the sale of the HSM units and the Platform services to the value-added distributors. The revenue target for 2026 targeted €15.8M. In the SME Phase 1 project I4P would like to assess the business viability of the service platform and validate the final scalable service options to prepare the phase 2 projects. The team with 60+ years of experience in the IT security industry, and headed by Mr. Zsolt Rózsahegyi, founder of NetLock Ltd, is perfectly aligned to achieve success at the global market.

Keywords: hardware security module,multi party computation,cybersecurity for sme,data protection,security key management,cryptography management
ERA-Net Smart Grids Plus: support deep knowledge sharing between regional and European Smart Grids initiatives (ERANet SmartGridPlus)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: ERA-NET Cofund
Partnership: ERANet SmartGridPlus (ERA-NET)
Countries involved: Austria,Spain,Italy,Germany,Switzerland,Norway,Belgium,Belgium,Finland,Croatia,Poland,Romania,Slovenia,Sweden,Türkiye,Latvia,France,Netherlands,Denmark,Denmark,United Kingdom,Portugal
Call: Supporting Joint Actions on demonstration and validation of innovative energy solutions (H2020-LCE-2014-3, 2014)
Start date: 2015-01-30
End date: 2020-04-29
Duration (months): 63.0
Total project cost (EUR): 30853961.72
EU funding (EUR): 9149908.26
Participants: 28
Project status: SIGNED

"From local trials to a European knowledge community". The challenges of modernising the electricity grids in Europe lies in enabling an increased flexibility of the European power system, efficiently providing increased transfer capacity and enabling an active participation of users and new market actors (by providing the information, services, market architectures and privacy guarantees). To address these challenges, innovation is needed in system integration, interoperable technologies, services, tools, co-ordination schemes, business processes, market architectures and regulatory regimes to plan, build, monitor, control and safely operate end-to-end networks in an open, competitive, decarbonised, sustainable and climate-change resilient market, under normal and emergency conditions. The major challenge is now to overcome the fragmentation of knowledge and accelerate knowledge exchange between the already existing demonstration projects and R&D initiatives with the goal to enable them to develop European wide interoperable solutions, according to a common reference architecture. With this, critical masses shall be reached in the development of a European market for smart grids technology providers and smart grids service providers. This initiative does not intend to find the final specifications for smart grids, but to organise the learning down to regional Smart Grids stakeholders, beyond the demonstration phase towards implementation. The overall goal of the “ERA-Net Smart Grids Plus” is to support deep knowledge sharing between regional and European Smart Grids initiatives by financing 15-20 transnational projects on applied research, piloting and demonstration in the field of Smart Grids, taking a next step in Smart Grids development building on the knowledge base, R&D initiatives as well as research and demonstration facilities already in place at regional, national and European level. It will coordinate during 2015-19 national and regional RDD budgets of more than 30 M€.

Keywords: smart grids,renewable integration,innovation
Identification and characterization of new cytosolic ligands of Sortilin (SORT1LIG)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Protein trafficking is crucial to maintain organelle function and cellular homeostasis, and is regulated by sorting receptors. Sortilin is a membrane receptor that sorts proteins to the predisposed cellular compartments through both secretory and endocytic routes. To accomplish this function Sortilin is endowed with an ectodomain that binds a great variety of cargo proteins, and a cytosolic domain that recruits adaptor proteins to direct the receptor trafficking activities. In the last 15 years more than 20 cargo proteins of Sortilin have been identified leading to the discovery of key Sortilin functions related to lipoprotein metabolism, neurotrophic factor signaling and lysosomal trafficking. However, little is known about the specific mechanisms that regulate Sortilin intracellular trafficking and function, since few cytosolic adaptors, shared with other sorting receptors, have been identified. Based on this, the aim of the present project is to identify and characterize new cytosolic adaptors of Sortilin and shed light on these fundamental aspects. In particular, I will isolate, validate and characterize new adaptors and their binding sites, starting from the outcome of a large-scale analysis of candidate Sortilin adaptors performed by the host research group. To this aim I will use multiple techniques developed for the study of protein-protein interaction and cell biology. The results of this study will provide new knowledge about the Sortilin binding ability, intracellular trafficking and function. Importantly, elucidating the machinery and the molecular/regulatory mechanisms of protein trafficking is crucial to understand cellular physiology and pathology. In addition, since Sortilin is emerging as a major disease gene in cardiovascular, neurological, and neurodegenerative disorders, the results from the present project will provide new knowledge about the etiology of these complex diseases and propose novel therapeutic perspectives for their treatment.

Keywords: sort1
PlotLab - Plot combines with integrated lab equipment for lean breading (PlotLab)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Denmark
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2014, 2014)
Start date: 2015-04-01
End date: 2015-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In order to feed the larger, more urban and richer population, food production must increase by 70%, and annual cereal production will need to rise to about 3 billion tonnes from 2.1 billion today. However, there are limited opportunities to expand the area of agricultural land without huge detrimental impact on the natural environment. As a consequence, sustainable increase of food supply must be based on productivity improvements. Plant breeding has significantly contributed to and will continue to be a major contributor to increased food security. The breeding and seed production process comprises many different stages. An important part is the process where varieties are selected for field tests and planted in small 10-15 m2 plots, often 10-thousind of such plots. The following step, where crop is harvested and the quality of the crops in individual plots are determined, is a resource and time consuming process. The process involves both specialised field equipment – the so-called plot combines for harvesting of the plots - and subsequent lab testing of the yield and quality parameters of crop to determine the 5%-20% candidates for further field testing. This project will bring new machinery to market which by integrating the field equipment (the plot combine) with lab equipment can shorten the time span of the breeding and seed production process, and has the potential to shorten the variety testing and selection process by a whole season. Moreover, by determining the quality parameters (water content, oil, protein, digestibility, sugar, etc.) at the time of the harvest, only the crop from fewer candidates plots needs to be packaged and handled for further processing, saving both significant labour efforts and reducing the risk of handling-related errors in the process.

Keywords: breeding,variety testing,crop yield
The Social Epistemology of Argumentation (SEA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Netherlands
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-07-01
End date: 2024-06-30
Duration (months): 72.0
Total project cost (EUR): 1683384.0
EU funding (EUR): 1683384.0
Participants: 1
Project status: SIGNED

Argumentation -the practice of giving and asking for reasons to support claims - is a key component of scientific inquiry, legal procedures, and political life. But in many instances, argumentation does not achieve its presumed goal of fostering consensus and circulation of reliable information. Recent events in world politics - Brexit, US elections, refugee crisis - demonstrate that a better grasp of what argumentation can and cannot do for us is urgently needed. The key question of this project is: ‘what does it take for a process of argumentation to improve our epistemic situation?’ Prior theories fail because they are based on overly idealized assumptions. This project develops a more realistic approach: argumentation is viewed as a practice interwoven with power relations, occurring in situations of epistemic and social diversity, and involving agents who are not ‘purely rational’. We will formulate the first comprehensive account of the social epistemology of argumentation, i.e. of the role of argumentation in processes of circulation and production of knowledge, evidence, and justification. To this end, we will bring together two research traditions that so far remain largely disconnected: social epistemology and argumentation theory. Our innovative hypothesis is that argumentation is a form of social exchange that can be successful to various degrees. What is exchanged are epistemic resources such as knowledge, evidence, justification, critical objections. Insights from social exchange theory will inform the investigation, a suitable framework for our purposes because it emphasizes the interplay between self-interest and interdependence. The result will be a realistic theory of the processes through which epistemic resources are shared and produced through argumentation. It will offer concrete prescriptions on how to optimize these processes, with wide-ranging applications wherever argumentation is crucial: scientific, legal, and political/public discourse.

Keywords: argumentation