Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
BraiN20®: A paradigm shift in Acute Ischemic Stroke (AIS) patient management (promise)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Spain
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-05-01
End date: 2026-04-30
Duration (months): 36.0
Total project cost (EUR): 5150878.25
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Acute Ischemic Stroke (AIS) represents 85% of strokes and is the 2nd leading cause of death and the leading cause of disability worldwide. Today, AIS patient management lies on imaging tools (multimodal CT/MRI) and scores to select patients for Endovascular treatment (EVT) – the gold standard. Still, its efficacy is limited to 46% due to the lack of tools to guide decision-making. BraiN20® is a non-invasive medical device class IIb that provides real-time monitoring of AIS patients’ brain viability, thereby predicting who will benefit from EVT. Time is Brain has the exclusive right to the IPR of a neurophysiological biomarker: N20, a SEP and surrogate of cerebral blood flow. TiB aims to implement the clinical trials to validate BraiN20®, acquire CE-Mark and FDA clearance, and bring it to market. By providing real-time and continuous monitoring of brain viability, BraiN20® will accelerate stroke management and predict EVT outcome and offer tailored care for each patient.

Keywords: neurophysiological biomarker n20,acute ischemic stroke,mechanical thrombectomy mt,endovascular treatment evt,ischemic penumbra,intraoperative monitoring
A simple, systematic and integrity-preserving model for values in science (SYSVAL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: CLOSED

In the face of controversial debates about appropriate influence of values in the assent phase of science (where hypotheses/theories are accepted or rejected), which provide only complicated guidelines on a case-by-case basis, a confused image of science arises in the view of policy makers, the wider public, and even scientists. Such unsettled debate has a potential negative impact on the trust the general public puts in science. Worse, it can be used by science deniers to support their undermining enterprise. This is why progress on this issue is of paramount importance. A simple and systematic model for incorporating values in the assent phase of science, while at the same time preserving its integrity, is sorely needed. This is what this project aims to achieve. 1. The project will start with a systematic analysis of the philosophical debate about values in science, in order to make an inventory and classify the various positions according to criteria such as value-freedom or value-ladenness, kinds of value, types of influence, priority of some values over others, etc. 2. Among these, a selection, at the conceptual level, will be made of the best candidate for a simple, systematic and integrity-preserving value-laden model -- which is the main methodological assumption of this project. 3. This model will be criticized and optimized, at the conceptual level (for both theoretical and practical goals), by providing: possible adjustments, complementations, objections, or simplifications. 4. This model will be confronted to empirical case studies, to illustrate, expand or revise it. Three case studies will be performed by the researcher: in aeronautical engineering, climate science and interdisciplinary studies in the social sciences. 5. Finally, the conceptual and empirical findings will be synthesized to reach an optimized (simple, systematic and integrity-preserving) model.

Keywords: epistemic and non epistemic values,acceptance rejection of scientific hypotheses,aeronautical engineering,climate science,sts,integrity of science,corpus model
Vehicle-Powered AI: Building Europe's Largest and Most Sustainable AI Computing Network (Skygrid)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Skygrid's mission is to decarbonize the AI revolution. Millions of self-driving ready cars are about to hit the road. They are supercomputers on wheels with their own power source and internet connection - but they will only be used an hour or two every day. Skygrid will unlock this dormant compute power to create a billion dollar marketplace for sustainable AI, turning cars into earning assets. Skygrid can reduce lifetime carbon emissions by more than 75% compared to even the most sustainable data centers. It achieves this by increasing the utilization of existing (but unused) hardware and hence avoids the huge CO2 costs entailed in the manufacture and supply-chain of new AI chips - fully in line with the European Green Deal’s imperative to decouple economic growth from resource use. Skygrid will create a Europe led global AI compute platform - vastly more climate friendly than anything else on the market.

Keywords: ai,distributed computing,inference,software defined vehicles
Breakthrough a glycyl radical enzyme long range activation mechanism (GREAM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-03
End date: 2026-06-02
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: SIGNED

Glycyl radical enzymes (GREs) are one of the most prominent biological catalysts in both strict and facultative anaerobes. They are responsible for a broad range of radical-based chemistry and catalyse reactions involved in diverse metabolic pathways such as acid fermentation, DNA synthesis and the anaerobic metabolism of pollutants. GREs are activated by members of the S-adenosylmethionine (SAM) radical family. Activation of GREs requires the formation of a protein-protein activation complex with the small GRE-AE. All known structures of GREs show that a major conformational change very likely occurs during the glycyl radical generation upon interaction with the GRE-AE. Only a structure of a GRE:AE holocomplex would shed light on the unprecedented conformational changes involved in GRE activation. Glycyl radicals and iron-sulfur clusters are extremely oxygen sensitive, rendering the proteins challenging to work with. GREAM will narrow a significant knowledge gap by studying the anaerobic class III RNR natural fusion (NrdD:NrdG). In order to study the mechanism of activation, GREAM will use an integrative research approach combining biochemical, biophysical and cryo-EM – assisted by X-ray crystallography. With my experience in anaerobic protein characterisation and crystallisation, I will join the Fontecave lab to build up on their experience in spectroscopic characterisation of oxygen-sensitive protein complexes and achieve the first aim or GREAM. During a secondment in the Logan lab, who are expert in structural characterisation of aRNRs and have a long lasting collaboration with the host, I will solve the anaerobic cryo-EM structure of the NrdD:NrdG holocomplex and achieve the final goal of GREAM. This newly established international collaboration will permit combining integrative approaches to successfully answer all GREAM’s questions and allow me to acquire invaluable experience in my future career.

Keywords: glycyl radical enzyme,x ray diffraction,cryo em,ribonucleotide reductases,oxygen sensitive enzymes,dna synthesis,protein complexes
Matter-Wave Interferometers (MAWI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy,France,Netherlands,Greece,Austria,United Kingdom,Australia,United Arab Emirates
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 2901049.71
EU funding (EUR): 2662308.0
Participants: 18
Project status: SIGNED

The field of matter-wave interferometry is emerging as a highly-promising interdisciplinary field, at the interface between fundamental science and quantum technologies/photonics/semiconductor European industry. The primary goals of MAWI are to use the exquisite control of ultracold quantum matter to implement guided matter-wave interferometers and to train young researchers in the emerging fields of matter-wave interferometry and quantum sensors based on interferometric schemes. The remit of MAWI is in the area of novel quantum sensing devices, with potential sensitivity enhancement of several orders of magnitude with respect to existing devices. Achieving this goal requires training the next generation of “quantum interferometry researchers” to a broad range of topics from fundamental to applied science, including both experimental developments and modelling, with strong connections to industry and emerging technological trends. Our training network focuses on the combination of optimal preparation of initial ultracold atomic sources and potentials to control and guide the atoms; their combination to build integrated guided atom interferometers for precision measurements, e.g., of rotations and accelerations; and technological advances towards their miniaturisation. The end goal of a fully-integrated cold atom quantum device could become a major commercial tool in the coming decade, complementing, or potentially even hybridising with, parallel developments in the photonics and semiconductor industries. Supported by our state-of-the-art facilities, our complementary expertise and skills, the participation of well-known European companies and a broad range of established external partners, we are poised to make lasting contributions to the scientific and technological developments of integrated matter-wave architectures and to the training of the next generation of research leaders who will propel quantum technologies even beyond our current expectations.

Keywords: interferometry quantum technology and quantum devices metrology and measurement photonics applications
From sky to seafloor observation: Achieving eXcellence in Oceanic surveiLlance and cOnservation Through deep Learning (AXOLOTL)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Information Science and Engineering
Countries involved: Cyprus,France,Belgium
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 1496433.13
EU funding (EUR): 1496433.13
Participants: 3
Project status: SIGNED

Technological areas such as Artificial Intelligence (AI) and ecosystems such as shipping, maritime and space have been strategically prioritised by Cyprus to improve its Research and Innovation (R&I) performance. At their intersection lies the need to enhance marine conservation efforts and maritime surveillance by leveraging deep learning (DL) methodologies built on standardized and robust data sets. Indeed, in-situ sampling stands as a cornerstone in marine conservation, offering a direct approach to monitoring marine biodiversity; while remote sensing stands as a pivotal addition to maritime surveillance, expanding the scope beyond traditional Automatic Identification System capabilities. DL, as a cutting-edge AI tool, holds immense potential to enhance the analysis of in-situ samples and remotely sensed data. AXOLOTL is proposed as a transformational international endeavour capable of enhancing the R&I capacity of CMMI, Cyprus and Europe in the interdisciplinary fields of DL-enhanced in-situ biodiversity assessment and DL-enhanced remote sensing for maritime surveillance. The project will contribute to closing the gap between a H2020 Teaming Centre of excellence and 2 strong innovators from France and Belgium through capacity-building, knowledge transfer, networking, and outreach activities at regional and international levels. Activities will go beyond the strictly scientific scope and support the mutual development, consolidation, and reinforcement of administrative, dissemination and entrepreneurial competencies, access to networks of excellence and the sustainable linkage between partners. The project’s R&I component will develop new strategies for improving data quality, standardization, and synchronization issues, devise novel interdisciplinary methodologies, develop robust DL models from state-of-the-art computer vision methods, and validate its proposed solutions in 2 relevant real-world contexts (biodiversity assessment and maritime surveillance).

Keywords: artificial intelligence automatic identification systems autonomous reef monitoring structures computer vision deep learning earth observation marine conservation maritime surveillance
Hydride and hydrogen transfer activity in enzymatic and nonenzymatic systems through the lens of three-component thermodynamics - study of the role of enzymatic microenvironments (MicroEnv)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 150438.72
EU funding (EUR): 150438.72
Participants: 1
Project status: SIGNED

The crucial step for selective cleavage and formation of C-H bonds is a concerted transfer of proton (PT) and electron(s) (ET): hydrogen atom abstraction (HAA) or hydride transfer (HT). The HAA and HT processes can be employed to various chemical transformations: from activation of inert bonds to reduction of CO2. This approach, however, requires a strict control of the regioselectivity of the reaction. Notably, enzymes - catalysts developed by Nature, are characterised by high activity and selectivity. In this project, we would like to provide insight into the interplay of reaction thermodynamics and sterics given by the microenvironment of prototypical enzymatic active sites (employing HAA or HT as a key step in catalysis) and to decipher which of these effects is more important in enzymatic selectivity. The focal point of the project is the novel three component thermodynamic-based model for reactivity, developed for concerted H+/e− abstraction. The model captures the coupled nature of PT and ET by the relative magnitutes of redox potentials and acidity constants of the reactants - their values determine not only the the reaction driving force but also the two novel contributions: asynchronicity and frustration with opposing effects on the barrier for the reaction. An asynchronous process, featuring a large disparity in ET and PT components of the reaction driving force, is more efficient. In contrast, a common large size of these ET and PT components makes HAA more frustrated and hence less effective. Based on this model we would like to look into systems capable of CO2 reduction and C-H bond activation to assess to what extent their reactivity is tweaked by the local conditions given by the enzymatic microenvironment versus the “canonical” factors affecting enzymatic activity, such as sterics and specific interactions. The studies may serve as a guide for design for systems capable of effective reduction of CO2 and rational redesign of C-H activating enzymes.

Keywords: c h bond activation formation hydride transfer hydrogen atom transfer reaction mechanisms enzymatic reactions thermodynamics
Beyond the Big Tech: Contentious Speech on Small Platforms (SMALLPLATFORMS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 1988113.0
EU funding (EUR): 1988113.0
Participants: 1
Project status: SIGNED

In 2022, following Elon Musk’s takeover of Twitter, users of the microblogging platform who feared a rise in far-right discourses with the new owner’s idiosyncratic free speech policies, announced their migration to Mastodon—a free, federated social networking service. In 2021, in India, following Twitter’s actions against hateful speech, religious majoritarian actors rushed to secure their spot on Koo, a new homegrown platform. In the UK, Britain First, a far-right movement known for its anti-immigration rhetoric, migrated to Gab (microblogging) and Telegram (messaging) after facing bans on Twitter and Facebook. Such emerging trends signal the growing importance of smaller social media platforms. Drawing the focus on such platforms, this project sets up small platform discourse as an object of anthropological inquiry. Grounded in anthropology and backed with policy analysis, algorithm auditing and computational natural language processing (NLP) and social network analysis (SNA), SMALLPLATFORMS will be the first study to explore small platforms in a cross-cultural framework spanning on-ground and online inquiries, and the global North (Germany, UK) and the South (Kenya, India). Using a unique conceptual model that considers the restrictive and generative sides of small platform discourse as a dialectical relation, and explicating three structural tensions among global capital, technopolitics and speech regulation that underlie this relation, the project asks whether and in what ways forms of contentious speech are bound up with practices surrounding small platforms. Through this empirical excavation with policy implications, the project will theorize digital discourse beyond the conceptual language of the centralizing Big Tech. With extensive theoretical and comparative work on online speech, the PI will drive this research using networks and knowledge about the selected sites and the profound global dimensions of digital media.

Keywords: online extreme speech,social media,mixed methods,ethnography,anthropology,media theory
Revolutionary energy storage cycle with carbon free aluminium (REVEAL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Countries involved: Iceland,Switzerland,Slovenia,Norway,Netherlands,Czechia,Germany
Call: Emerging technologies for a climate neutral Europe (HORIZON-CL5-2021-D2-01, 2021)
Start date: 2022-07-01
End date: 2026-06-30
Duration (months): 48.0
Total project cost (EUR): 2499468.79
EU funding (EUR): 2499468.75
Participants: 9
Project status: SIGNED

One of the main keys – and possibly THE main key - for a climate neutral Europe are technologies for the storage of renewable energies over longer time at an attractive cost and with an acceptable environmental impact. Renewable electricity and heat can be produced cheaply today and short-term storage solutions for evening out mismatches between production and demand are available at low cost. However, technologies for storing renewables for longer time-spans of months or seasons are scarce and costly and thus not widely used yet. Therefore, the REVEAL project develops a game-changing and unique solution to this challenge, using the conversion of aluminium oxide into aluminium metal (Power-to-Al) in an environmentally friendly way to store renewable energy and produce a "renewable fuel" in the form of aluminium. This ground-breaking technical solution will enable to store large amounts of energy with an unmatched energy storage density of over 15 MWh/m3 at an attractively low cost, without losses and with lower environmental impact than today's solutions. For example: cost for converting electricity into a seasonally storable form will be less than 7 ct/kWh, and the easy transportable energy vector can be used for heat and electricity or hydrogen production wherever and whenever needed, in scalable units from few kW to the MW range. Thus, this breakthrough high-density storage solution will enable to cover energy demands flexibly also in small units and off-grid situations, and – above all – in seasons where the demand is much higher than local renewable production could possibly cover. Therefore, with the emerging technology of carbon free reduction of aluminium oxide to aluminium in combination with the release of energy from an aluminium storage vector this project will provide one of the missing pieces of the puzzle for a climate neutral Europe.

Keywords: renewable energy storage