Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reducing the impact of major environmental challenges on mental health (environMENTAL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Germany,Norway,France,Spain,China,United States,United Kingdom,Austria,Netherlands
Call: Towards a molecular and neurobiological understanding of mental health and mental illness for the benefit of citizens and patients (HORIZON-HLTH-2021-STAYHLTH-01, 2021)
Start date: 2022-06-01
End date: 2027-05-31
Duration (months): 60.0
Total project cost (EUR): 9053914.75
EU funding (EUR): 9045288.0
Participants: 28
Project status: SIGNED

The environMENTAL project will investigate how some of the greatest global environmental challenges, climate change, urbanisation, and psychosocial stress caused by the COVID-19-pandemic affect mental health over the lifespan. It will identify their underlying molecular mechanisms and develop preventions and early interventions. Leveraging cohort data of over 1.5 million European citizens and patients enriched with deep phenotyping data from large scale behavioural neuroimaging cohorts, we will identify brain mechanisms related to environmental adversity underlying symptoms of depression, anxiety, stress and substance abuse. By linking population and patient data via geo-location to spatiotemporal environmental data derived from remote sensing satellites, climate models, regional-socioeconomic data and digital health applications, our interdisciplinary team will develop a neurocognitive model of multimodal environmental signatures related to transdiagnostic symptom groups that are characterised by shared brain mechanisms. We will uncover the molecular basis underlying these mechanisms using multi-modal -omics analyses, brain organoids and virtual brain simulations, thus providing an integrated perspective for each individual across the lifespan and spectrum of functioning. The insight gained will be applied to developing risk biomarkers and stratification markers. We will then screen for pharmacological compounds targeting the molecular mechanisms discovered. We will also reduce symptom development and progression using virtual reality interventions based on the adverse environmental features - developed in close collaboration with stakeholders. Overall, this project will lead to objective biomarkers and evidence-based pharmacologic and VR-based interventions that will significantly prevent and improve outcomes of environmentally-related mental illnesses, and empower EU citizens to manage better their mental health and well-being.

Keywords: population,deep phenotyping,environmental adversity,mental illness,molecular characterisation,virtual reality,compound screening,stakeholder participation,biomarkers,prevention
LET´S CARE: BUILDING SAFE AND CARING SCHOOLS TO FOSTER EDUCATIONAL INCLUSION AND SCHOOL ACHIEVEMENT (LET´S CARE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Spain,Austria,Italy,Belgium,Poland,Lithuania,Portugal,Bulgaria
Call: Addressing poor learning outcomes in basic skills and early school leaving at national, regional and local level in Europe (HORIZON-CL2-2021-TRANSFORMATIONS-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 2953671.88
EU funding (EUR): 2953668.25
Participants: 14
Project status: SIGNED

Secure attachment relationships play an important protective role against the intergenerational transmission of social exclusion, not only at early stages, but at all school levels. LET´S CARE aims to comprehensively understand and improve the caring dimension of educational inclusion and school success. The project main objective is to identify determinants affecting student security as a root cause of underachievement, disengagement and school dropout, at 4 different ecological levels: individual, relational, community and political. LET´S CARE will create a theoretical and practical framework to foster Safe Learning, Safe Teaching, Safe Schools and Safe Education in each level as an approach to break the chain of transgenerational transmission of educational and social exclusion. This approach will generate lower rates of school failure, poor learning outcomes and early school leaving. The main proposal breakthrough is based on considering a relational response to educational exclusion and inequality, resulting in a model for understanding the importance of security to address underachievement and early drop out, and a relational approach to inclusive practices at school that will be translated into tools, recommendations and guidelines for action, from ECEC to secondary and Second Chance schools. A multilevel, multistage and intersectional research, exploring different European educational contexts, will be implemented, including120 schools, 18,000 students, and 2,400 teachers from 6 European countries in 4 schools stages, with special attention to multi-disadvantaged learners. LET´S CARE, supported by a expert consortium, will implement a holistic methodological approach, including cocreation mechanisms, and will translate research findings into political approach, through formulation of novel evidence-based policy recommendations, raising awareness on safe/caring schools, combating social exclusion of disadvantaged learners.

Keywords: safe education,underachievement,school dropout,disengagement,educational exclusion,secure attachment,safe communities
Excellence hub in green technologies: Introducing innovation ecosystems in the Mediterranean food value chain (EXCEL4MED)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Greece,Malta,France
Call: Excellence Hubs (HORIZON-WIDERA-2022-ACCESS-04, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 3743545.0
EU funding (EUR): 3720420.5
Participants: 14
Project status: SIGNED

The excellence hub EXCEL4MED is an initiative to strengthen Mediterranean innovation excellence in innovation ecosystems focusing on the production of nutritious food products and the valorization of food industrial side-streams. It is a cross-border collaboration between Greece, Malta and France on a common strategy on strengthening the Mediterranean food added-value chains. EXCEL4MED innovation ecosystems will be interconnected with umbrella company organizations, research institutions, governmental bodies and societal actors that will be mutually reinforcing each other in a Mediterranean context and together will raise the level of innovation excellence in their regional fabric.

Keywords: green technologies,ecosystem,food innovation,resilient food chain,business plan
International Conference on Research Infrastructures (ICRI) 2026 in Rome (Italy) (ICRI 2026)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Other destinations
Action type: Coordination and support actions
Countries involved: Italy
Call: International Conference on Research Infrastructures – ICRI 2026 (HORIZON-INFRA-2025-ICRI-IBA, 2025)
Start date: 2025-10-01
End date: 2027-03-31
Duration (months): 18.0
Total project cost (EUR): 300000.0
EU funding (EUR): 300000.0
Participants: 1
Project status: SIGNED

The International Conference on Research Infrastructures (ICRI) is a significant event that convenes policy experts, facility managers, leading researchers, and various other stakeholders to discuss challenges and emerging trends for research infrastructures (RIs) in the global context. The aim of the project is to facilitate the organization of the ICRI 2026 conference in Rome, Italy, in October 2026. The conference will be organized by the Consiglio Nazionale delle Ricerche (CNR), the largest public research institution in Italy, which coordinates scientific research across disciplines, sectors, and regions. This effort will be in collaboration with the Italian Ministry of University and Research (MUR) and under the auspices of the European Commission (EC). The overall objectives of ICRI 2026 are to explore and promote the dual role of research infrastructures as: -Drivers of socio-economic impact, through developing frameworks that measure their contributions to research, innovation, regional and global development, public services, workforce skills, and broader societal benefits. -Instruments of science diplomacy, by demonstrating how RIs facilitate international collaboration, foster trust among nations, support global scientific responses, and contribute to peace, openness, and mutual understanding. Improved policy and management in the area of research infrastructures may have widespread impact across regional economies and significantly contribute to addressing global challenges. ICRI 2026 will facilitate the sharing of knowledge and the dissemination of best practices on effectively organizing RIs.

Keywords: research infrastructures,international cooperation,randi policy
Simulation-Based Imaging: A New Tool for Revolutionizing the Diagnosis and Treatment of Cardiovascular Disease (SBI-Cardio)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Cyprus,Sweden,United States
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 164328.0
EU funding (EUR): 164328.0
Participants: 3
Project status: SIGNED

The 3D, time-resolved blood flow measurement technique known as 4D Flow Magnetic Resonance Imaging (MRI) is highly valuable for research and can play a crucial role in cardiovascular disease (CVD) diagnosis and treatment planning. However, it is limited by the fundamental trade-off between resolution, image quality, and scan time since current 4D Flow MRI methods use compressed sensing or spatiotemporal acceleration to achieve only a spatial resolution of 1-3mm and temporal resolution of 25-100ms in a scan time of ~10 minutes. To overcome this challenge, simulation-based imaging (SBI) may provide a method to augment 4D flow MRI data by fitting computational fluid dynamics (CFD) simulation to low-resolution and noisy 4D Flow MRI data. The primary objective of SBI is to generate a high-resolution velocity field by optimizing the simulation to closely match the available data. This approach overcomes the aforementioned limitations of 4D Flow MRI, which often suffers from inherent errors in resolution and scan time, leading to both quantitative and qualitative discrepancies. By utilizing SBI, a more precise and comprehensive visualization of blood flow can be achieved. Therefore, the ultimate goal of this project is to develop a novel SBI method for MRI that will be used to address a wide range of cardiovascular (CVDs) such as heart attacks, strokes, and congenital heart defects; providing high-quality images of structure and function with ultra-high resolution and fast scan time. The long-term impact of the proposed SBI framework is expected to revolutionize clinical diagnosis and surgical decision-making leading to more effective treatments and improved outcomes for CVD patients.

Keywords: simulation based imaging 4d flow mri blood flow computational fluid dynamics high resolution imaging cardiovascular disease diagnosis wall shear stress
Flow-Reactor Coupled 3D Printing: Achieving Voxel-Level Control of Out-of-Equilibrium Materials (FloR3D)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Netherlands,United States
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-01-31
Duration (months): 24.0
Total project cost (EUR): 183174.24
EU funding (EUR): 183174.24
Participants: 2
Project status: SIGNED

Nature has optimized the properties of its building blocks by spatially varying hierarchical microstructures within complex form factors. Additive manufacturing techniques, in particular direct ink writing (DIW), are promising pathways towards replicating these systems synthetically, leading to printed materials with tarilored materials properties. However, current DIW techniques do not offer access to out-of-equilibrium materials, greatly limiting printable microstructures. To overcome this limitation, a new DIW technique, termed FloR3D, will be developed in this project. By integrating an evolving chemical reaction into the printing process itself, this Flow-Reactor coupled 3D printing technique allows for out-of-equilibrium microstructures to be generated within the nozzle, which is subsequently trapped upon deposition. Through on-the-fly variations of the relative flow rates into the flow reactor, FloR3D will allow for voxel-level control of the material composition and microstructure, resulting in optimized and spatially-varied hierarchical structures. By incorporating a polymerization-induced microphase separation (PIMS) process, spinodally-decomposed bicontinuous microstructures, which was previously unachievable by DIW, will be printed. Printing these bicontinuous systems, commonly used in nature to exhibit structural coloration, will result in angular-independent structural colored materials with arbitrary form factor. Furthermore, by including photoresponsive monomers within the PIMS system and an in-situ UV source, the materials' refractive indices can be tuned independently of the microstructural feature size, resulting in materials with gradient and spatially-patterned optical properties. Ultimately, beyond the complex photonic materials produced in this proposal, the design of FloR3D can be broadened to incorporate a variety of other chemical reactions, leading to a new pathway towards free-form high-performance materials.

Keywords: additive manufacturing,structural color,photochemistry
Establishing of Cancer Mission Hubs: Networks and Synergies (ECHoS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Cancer
Destination: Cancer
Action type: Coordination and support actions
Countries involved: Portugal,Finland,Germany,Greece,Hungary,Ireland,Israel,Italy,Austria,Lithuania,Luxembourg,Malta,Netherlands,Norway,Poland,Belgium,Romania,Slovakia,Slovenia,Spain,Sweden,France,Cyprus,Czechia,Estonia,Türkiye,Latvia,Croatia,Bulgaria,Denmark
Call: Establishing of national cancer mission hubs and creation of network to support the Mission on Cancer (HORIZON-MISS-2022-CANCER-01, 2022)
Start date: 2023-04-01
End date: 2026-03-31
Duration (months): 36.0
Total project cost (EUR): 6185678.76
EU funding (EUR): 6096147.5
Participants: 63
Project status: SIGNED

Cancer- healthcare, research and innovation face core common challenges, such as fragmentation of initiatives and distancing from important stakeholders, requiring coordinated solutions. These challenges are recognized in Horizon Europe’s Cancer Mission Implementation Plan and in Europe’s Beating Cancer Plan. The proposal Establishing of Cancer Mission Hubs: Networks and Synergies (ECHoS) represents a unique opportunity to coordinate R&I and Healthcare actions on cancer with policy-making processes creating transnational communication & collaboration networks aligned with Cancer Mission objectives. Experiences shows that the setup and implementation of innovative health solutions are more likely to be successful when a broad range of stakeholders and decision-makers from the public and private sectors are part of the process. By fostering the creation of National Cancer Mission Hubs (NCMHs) in member states and associated countries ECHoS will create the conditions for organized stakeholders and individual citizens to collaborate and engage in policy dialogues. The implementation of the Cancer Mission objectives will promote more resilient and people-centric healthcare and research systems. ECHoS will produce (i) general models and guidelines for the creation of sustainable NCMHs, (ii) a knowledge exchange programme to support development of NCMHs competences, (iii) impact models and training sets to help efficiently engaging with distinct stakeholders, (iv) a toolkit for synergies to help NCMH engaging in collaborative work with individual European Initiatives, (v) a business continuity model envisaging long-term sustainability of a EU network of NCMHs and (vi) a calendar of events to create awareness on NCMHs and to help closing the gap in citizens’ participation in cancer policy. In summary, ECHoS will create conditions for NCMHs to be Mission Cancer advocates in MS/AC and set the pace for the development of a transnational network of NCMHs in a second phase.

Keywords: cancer,mission,hubs,policy,citizens,research,health,
Next-generation fungicides for crop protection based on artificial small RNAs derived from viral vectors (FunSynVIGS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-12-01
End date: 2026-11-30
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Plants are threatened by a plethora of pathogens, with fungi accounting for important crop and post-harvest losses worldwide. Despite widespread spraying of fungicides, losses keep rising in the current warming world and the increasing use of chemical (and toxic) fungicides favours the emergence of resistant fungi strains. Hence, there is an urgent need to develop a new generation of highly efficient and environmental-friendly fungicides for securing present and future food availability. Classic RNA interference (RNAi) tools based on double-stranded RNA have been used for inducing antifungal resistance in plants, despite their lack of high specificity. More modern and highly specific RNAi tools are based on artificial small RNAs (art-sRNAs). Art-sRNA tools have been optimized mainly for high efficacy and transgenic use but are not well adapted for GMO-free application and have not been used yet for inducing antifungal resistance in plants. FunSynVIGS seeks to develop a novel, GMO-free RNAi technology consisting in systemic, viral vector-based fungicides expressing art-sRNAs for plant immunization against pathogenic fungi. The specific objectives are: (1) The development and optimization of viral vector-based fungicides expressing art-sRNAs against Botrytis cinerea, the causal agent of the gray mold disease, in the model plant species Nicotiana benthamiana. (2) The application of viral vector-based fungicides for immunizing tomato plants against B. cinerea. Successful completion of these objectives will provide a novel class of mobile RNAi-based fungicides for inducing highly efficient antifungal resistance in crops.

Keywords: rnai artificial small rnas pathogenic fungi next generation fungicides plant
Unity and diversity in southern African hunter-gatherers: the ethnographic, rock art and excavated archaeological evidence (SAHUD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Project SAHUD uses a regional case study to advance the global understanding of small-scale image-making societies. The rich and mutually illuminating relationships between ethnographic, rock art and excavated archaeological data in southern Africa are unavailable to rock art researchers in most other contexts, such as the European Upper Palaeolithic, where analogies often employ southern African ethnographies. However, despite the potential offered by this wealth of data, previous southern African archaeological research has focused on an overly small sample of local ethnographies to interpret inter-group differences in technological and subsistence adaptations to a range of environments and wild plants and animals. Simultaneously, ethnographic and rock art evidence has been used to emphasise practices and beliefs that transcend multiple hunter-gatherer groups across time and space. A novel, holistic integration is needed that is sensitive to all the available evidence and varied theoretical frameworks. The project’s key question is: does the evidence for diversity across ethnographic and mid- to late Holocene archaeological hunter-gatherers in southern Africa eclipse the widespread parallels and continuities in beliefs and practices? This question will be addressed in three interrelated ‘work packages’ that draw on published literature and archives in the United Kingdom and South Africa. The project uniquely analyses diversity across three traditionally independent research fields. The outcomes — including a novel database of ethnographic southern African hunter-gatherer diversity for archaeological investigations, and testing its potential for guiding studies of rock art diversity and for enriching discussion of archaeological diversity among southern African hunter-gatherers — will collectively constitute a new integrated synthesis of southern African hunter-gatherers between ~8,000 and 2,000 years ago.

Keywords: archaeology hunter gatherers rock art diversity ethnography southern africa
Chip-scale Optical Atomic Clock (CSOC)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Belgium,Germany,Denmark,Switzerland,Poland
Call: EIC Pathfinder Open 2021 (HORIZON-EIC-2021-PATHFINDEROPEN-01, 2021)
Start date: 2022-10-01
End date: 2026-03-31
Duration (months): 42.0
Total project cost (EUR): 2687263.75
EU funding (EUR): 2687263.75
Participants: 6
Project status: SIGNED

Optical atomic clocks are at the heart of modern technology. From time-keeping to navigation to global positioning systems. This project will develop the world’s first all optical atomic clock that is chip scale. It will create this based on recent advances in Kerr soliton micro-comb technology, ps mode locked lasers that are heterogeneously integrated on a chip, and using novel on chip frequency doublers with vastly improved efficiency. Exploiting the Rb85 two photon transition enables to obtain a clock signal that is vastly improved compared to today’s radio frequency transition based clocks. This clock can revolutionize timekeeping in both mobile, airborne or space application and used in future GPS networks such as Galileo. Moreover the underlying clockwork - a chipscale comb - can have applications ranging from distance measurements, to time and frequency metrology. This consortium brings together the leading groups in Europe in the domain of Frequency combs, micro-comb technology and photonic chipscale laser integration.

Keywords: atomic clock,frequency comb,photonic chip