Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cultural heritage in South Tunisia. A twinning project promoting interdisciplinary and participatory sciences for an inclusive society. (SfaxForward)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Belgium,Tunisia,France,France,France
Call: Twinning (H2020-WIDESPREAD-2018-03, 2018)
Start date: 2019-10-01
End date: 2023-03-31
Duration (months): 42.0
Total project cost (EUR): 799787.5
EU funding (EUR): 799787.0
Participants: 7
Project status: SIGNED

Since 2011, Tunisia has been the theatre of a profound social, political and economic transformation. The Humanities and Social Sciences can develop tools enabling Tunisian society to appropriate and perpetuate this transformation. Within this context, the “SfaxForward” Twinning project strengthens the capacities of an innovative academic centre regarding Cultural Heritage: the Maghreb House of the Humanities and Social Sciences (MdMSH) at the University of Sfax. SfaxForward postulates that Tangible and Intangible Heritage can play a central role in a territory’s transformation and development. By learning to cherish their Cultural Heritage, people can discover who they are and what they share. The characterization and subsequent participatory management of these common cultural assets should engender a more stable and inclusive society. One that better manages migratory flows thanks to its citizens enjoying greater control over their lives, while constructing and taking possession of their own territory. SfaxForward’s goal is to position the Sfax partner as an international model for mutually beneficial relations between academia and civil society, with Heritage serving as a driving force of regional development and stability. This necessitates establishing the conditions for a fruitful dialogue between researchers and civil society to enlighten public policy and action. Southern Tunisia constitutes the project’s territory-laboratory. To achieve this goal, SfaxForward develops three types of initiatives: multidisciplinary conferences and workshops on the project’s key themes, thematic schools dedicated to young researchers, and an Observatory of Southern Tunisian Heritage constructed in collaboration with civil society. The extensive interdisciplinary experience of the collaborating French and Belgian Houses of the Humanities and Social Sciences benefits MdMSH in constructing its own unique scientific identity, with an ambition for international excellence.

Keywords: cultural heritage,commons,tunisia,transition,inclusive societies,governance,civil society,resources,environment,migrations
Boosting advanced doctoral training in innovative colon targeting drugs (COLOTAN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland,Italy,Greece,Sweden,Belgium,Belgium,Sweden,Belgium,Denmark,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 3533108.04
EU funding (EUR): 3533108.04
Participants: 10
Project status: SIGNED

The Colon Targeting Network (COLOTAN) is a European Training Network that will train 13 Early Stage Researchers (ESRs) in (bio)pharmaceutical sciences to improve targeting of oral drugs to the colon. Oral administration of drugs is the preferred delivery route due to its non-invasiveness and convenience for the patient. However, issues related to solubility, absorption, and metabolism often cause oral drug candidate attrition. Oral formulations that release the drug in a pH- or time-dependent manner in the colon have been developed for local treatment of colonic diseases. However, currently available colon-targeting formulations suffer from an inconsistent performance and lack of efficiency due to intra- and interindividual (patho)physiological variability. Moreover, the available tools to predict drug absorption mainly focus on the upper gastrointestinal tract and fail to recapitulate events occurring in the colon, resulting in a lack of validated models to predict drug and formulation behaviour in the colon. To meet these challenges, we must move beyond traditional, mainly monodisciplinary education and train a new generation of pharmaceutical scientists in diverse disciplines ranging from drug delivery to chemistry, cell biology, microbiology and gastroenterology. In an ambitious intersectoral environment, COLOTAN will deliver this new generation via an advanced research and training programme with a total value of 180 ECTS comprising challenging Individual Research Projects, workshops with joint training in scientific and transferable skills, online training, individual training, dissemination, outreach and career development activities. At the end of the project, all ESRs will obtain a doctoral degree. This new generation of ESRs will become future leaders in academia and industry and will be at the forefront of developing a new generation of innovative colon targeting drugs.

Keywords: drug delivery,new formulations,pharmaceutical technology,biopharmacy,pharmacokinetics,drug,absorption,gastroenterology,colon,gut microbiota,pharmacometrics,pbpk models,in vitro models
Hybrid Node Modes for Highly Efficient Light Concentrators (HyMoCo)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Germany
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-03-01
End date: 2020-02-29
Duration (months): 60.0
Total project cost (EUR): 1485000.0
EU funding (EUR): 1485000.0
Participants: 1
Project status: CLOSED

The meaning of solar energy for future decentralized power supply will largely depend on both efficiency and cost of solar to electrical power conversion. All kinds of conversion strategies including photovoltaics, concentrated solar power, solar to fuel and others would benefit from efficiently collecting solar power on large areas. For this reason luminescent solar concentrators have been developed for over thirty years, but due to waveguide losses their maximum size is still limited to a few centimeters. The proposed project suggests the exploitation of a new type of electromagnetic waveguide in order to realize passive planar concentrators of unsurpassed collection efficiency, size, concentration, lifetime and costs. A dielectric TE1-mode shows a node, a position in the waveguide where no intensity is found. A thin film placed in this node remains largely “invisible” for the propagating mode. Such dielectric node modes (DNMs) have been investigated by the applicant in previous work, but only recently a silver island film (SIF) was for the first time placed in such a node. The resulting extremely low waveguide losses cannot be explained by our current understanding of waveguide modes and hint to a hybridization between the SIF-bound long-range surface plasmon polaritons (LRSPPs) and the DNMs into what we call hybrid node modes (HNMs). The SIFs strongly interact with incident light. An appropriate nanopatterning of SIFs enables efficient excitation of low-loss HNMs modes collecting solar power over square meters and concentrating it. To achieve this goal new technological methods are used that enable patterning on the nanometer scale and low cost roll-to-roll processing at the same time. New measurement techniques and numerical simulation tools will be developed to investigate the HNMs – a novel kind of electromagnetic modes – and their exploitation in the passive solar concentrators.

Keywords: solar concentrators,waveguides,nanotransfer printing,silver island films,coalescence control,surface plasmon polaritons,hybrid modes
Resistance mechanisms to tyrosine kinase inhibitors in solid tumors (TKI resistance)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2016-12-01
End date: 2021-11-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Over the past 10 years, the chemotherapeutic arsenal has been expanded to include molecular-targeted therapies based on the principle that cancer cells become addicted to a single driver oncogene. However, use of these new therapies is limited due to development of acquired resistance. To fully understand how resistance develops, patient-derived models are an absolute pre-requisite, but establishing them remains extremely challenging. Few groups worldwide have successfully implemented a systematic standardized approach to facilitate translational cancer research discovery. My project aims to provide rational therapeutic guidance for combinatorial or adaptive designs to overcome acquired resistance to tyrosine kinase inhibitors (TKIs) in patients with oncogene-addiction. By establishing new laboratory models of resistance directly from patient biopsies (patient derived cell lines and xenografts) I will elucidate the molecular mechanisms whereby cancer cells escape targeted treatments. I will then implement innovative approaches to overcome resistance using TKI combinatorial screens, apoptosis sensitizers and by screening for epigenetic modifiers. Additionally, I will scrutinize the emergence of resistance acquisition in vitro. Current working models involve “persistor” cellular populations able to tolerate the TKI and, in a subsequent step, to become fully resistant to the drug. This drug tolerant persistor stage most probably involves epigenetic reprogrammation. An epigenetic inhibitor screen will be performed to identify agents able to interfere with the emergence of persistors and ultimately with the acquisition of TKI resistance. These results should provide an alternative strategy to validate innovative combinatorial drug strategies to avoid emergence of resistance in patients.

Keywords: tyrosine kinase inhibitor targeted therapy resistance
Feasibility study for scaling UP thermal conversion technology that turns scrap TYREs into high quality resources (UP-TYRE)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Estonia
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

UP-TYRE project proposes an environmentally friendly, efficient and profitable solution for converting scrap tyres into high quality products, such as light heating oil used in heat and power generation. State-of-the-art alternative technologies, for instance tyre pyrolysis, are energy-intensive, costly and yield little varieties of low value products. The thermal conversion reactor proposed by Meratel allows converting tyres into high yield of high quality products without generating additional waste or pollution, while redefining scrap tyres from a costly problem to a valuable resource for tyre management companies. The proposed thermal conversion technology has significant advantages that translate into over 40% cost saving for heat and power plants across Europe when substituting regular fossil fuels with the proposed tyre-derived light heating oil. The European market for light heating oil is substantial in size and looking for alternatives to reduce reliance on fossil fuels. Coupled with stable supply of scrap tyres and environmentally friendly processing method, the proposed technology has ample commercial potential. The proposed technology has already been demonstrated in relevant environment on a small scale, but it is necessary to fully estimate the commercial feasibility of the method to ensure the best possible strategy for a successful commercialization. The work planned in Phase 1 will cover all the aspects regarding this objective: a detailed business plan creation, IPR study, and the final technology configuration to enable scale-up of the proposed technology. The overall objective of the innovation project is scaling up the proposed technology on a European scale. Before this can be done, an appropriate automation and control system needs to be developed and integrated into the technology. Meratel intends to define the specifications for such system during the feasibility study and continue system design and development in Phase 2 project.

Keywords: business plan development,freedom to operate study,tyre recycling,light heating oil,energy recovery,tyre derived fuels
Enhancing biological drug production through protein secretion (SECReTE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-12-01
End date: 2020-05-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Biotherapeutics are bio-materials, which are used among others to treat cancer, diabetes, and rare diseases. It is expected that these medicines will make up half of the medicines in future. Already now, 350 million patients are treated with biotherapeutics, produced from proteins. The proteins that are injected to humans must be “clean” and pure. However, harvesting a protein from cells and purifying it is a daunting challenge. Current harvesting methods are complicated and expensive. We made a discovery, which would significantly improve the harvesting and purification process, therefore lowering drug production costs. In this process, biological cells are producing desired proteins from a gene that was planted into the cell’s genome. The key is that after the protein has been produced within cells, we will then induce the cells to send the protein outside – to the liquid medium. This makes the harvesting and purification process much more efficient. The innovation lies in encoding the protein with RNA-based tag. When attached to a gene of interest, the tag will make the producing cell secrete the encoded protein to the medium. If we program proteins to be secreted to the extracellular medium more efficiently protein harvesting and purification process in Pharma, Biotech and Agricultural industries could be revolutionized. This is extremely important for the Pharma industry, which is struggling on low return on investment, already threatening the sector’s viability. Quicker drug development process, cheaper and higher quality production and improved ROI will create also societal benefit. In the end, new drugs can be discovered and brought to markets quicker. In the PoC, we will characterize and discover the best tags for protein production and secretion and use it to secret key drugs essential for the Pharma industry, and demonstrate the feasibility of our technology and carry out pre-commercialization actions in order to shorten our innovation’s time to market.

Keywords: drug development,biotechnology,heterologous protein expression,rna localization,commercialization,protein purification,biotherapeutics
The refinement, miniaturisation and demonstration of an ultra low flush toilet capable of saving 2.8 billion litres of clean, potable water being unnecessarily wasted in Europe every day. (Propelair)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: United Kingdom
Call: Boosting the potential of small businesses in the areas of climate action, environment, resource efficiency and raw materials (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2017-10-01
End date: 2021-03-31
Duration (months): 42.0
Total project cost (EUR): 1271786.5
EU funding (EUR): 890250.0
Participants: 1
Project status: CLOSED

As reported by the European Environment Agency, 70million people in Europe are living in water stressed areas. In the Mediterranean region that figure rises to 53%. Water shortages affect almost every country in Europe and the problem is getting worse. Water consumption per person is increasing significantly; by 55% in the last 25 years. European flushing toilets (WCs) waste valuable, potable water on an unprecedented scale. The 392m installed base of toilets across the EU currently ‘flush’ away 102bn litres of clean water every day. That is enough to drain Lake Geneva every 20 hours. There is clearly a pressing need for a novel technology to reduce the volume of water used in flushing toilets. Existing toilets including the latest ultra low, dual flush units, do not offer the level of water reduction required. Since water volume is integral to their operational mode, they are compromised and all require significant flush volumes to clean effectively. This project will demonstrate and bring to market readiness a 1.5L ultralow flush toilet that will reduce average toilet water consumption by 75% and directly save 2.8bn litres of water being unnecessarily wasted per day. Propelair also provides attractive economic benefits and rapid payback to customers. It reduces water bills on average by 60%, (typically €344 per unit p.a.) delivering a payback within just 1.2 years. This Dedicated SME Instrument project is essential for us to refine, miniaturise, demonstrate and cost reduce our prototype to overcome current barriers to market, including purchase price and lack of a proven long term demonstration. A successful project delivery will allow us to achieve cumulative sales of €80.7m and an EBITDA of €31.5m by 2023. At a modest 0.5% market penetration, we will our save customers 2.8bn litres of water day or 1.04bn m3 p.a. worth over €1.98bn. This proposal builds upon a previous proposal 755830 which scored 13.66 and received a Seal of Excellence.

Keywords: toilet,water saving,propelair,waste water,ultra,flush
Citizens Acting on Mitigation Pathways through Active Implementation of a Goal-setting Network (CAMPAIGNers)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Ireland,Azerbaijan,South Africa,Austria,Austria,Ireland,Italy,Italy,Germany,Germany,Germany,Germany,Belgium,Norway,Türkiye,Finland,Switzerland,Finland,Greece,Lithuania,Greece,Sweden,France,Peru
Call: Scientific support to designing mitigation pathways and policies (H2020-LC-CLA-2020-2, 2020)
Start date: 2021-05-01
End date: 2024-04-30
Duration (months): 36.0
Total project cost (EUR): 4999670.0
EU funding (EUR): 4999670.0
Participants: 31
Project status: SIGNED

Climate change is a human problem, caused by humans, affecting humans, and requiring a human-centric solution. CAMPAIGNers aims to make low-carbon lifestyles a major part of the solution by identifying lifestyle transformation potential, and associated barriers and enablers across 5 continents and 16 major cities with over 20 mil. residents. Feasible pathways to GHG mitigation are developed to include the empirically validated lifestyle changes, and are applied to the principal integrated modelling tools used in the EU to provide robust insights into the system-level impacts of large-scale lifestyle transformation. CAMPAIGNers builds on previous consortium-led projects that substantially improved the understanding of societal structures and interventions that encourage lifestyle shifts, and identified limitations to the existing evidence-base. Namely, current lifestyle transformation research is either limited to narrow, specific contexts or groups, or deals in hypothetical behaviours where most citizens do not have real experiences to draw on. CAMPAIGNers’ ground-breaking approach overcomes these drawbacks by implementing a ‘goal-setting network’, where over 100,000 citizens receive and create challenges to try out tailored adaptations to their daily routines via an engaging app. Their responses to these challenges, associated treatments, and short questionnaires will deliver unprecedented data of behavioural processes, (local) barriers to change, and motivators, allowing for empirically-based scientific support of cities in crafting policies to encourage low-carbon lifestyles. Together with local, national and EU policy makers insights are analysed regarding the ‘right-level-to-act’ and policy-ready recommendations are jointly derived. A workshop in the EU Parliament, hosted by First-Vice President Ms. McGuinness, and supported by 9 more MEPs from 6 countries and 4 political parties, will ensure high-level feedback and contribute to consensus building.

Keywords: lifestyle transformation,behavioural modelling,climate pathway modelling,integrated assessment modelling,smart phone app,citizen science,citizen movement,multi disciplinary research
RENewAble Integration and SuStainAbility iN energy CommunitiEs (RENAISSANCE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: A single, smart European electricity grid
Action type: Innovation actions
Countries involved: Spain,Spain,Spain,Spain,Spain,Italy,Greece,Belgium,Greece,Poland,Belgium,Netherlands,United Kingdom
Call: Integrated local energy systems (Energy islands) (H2020-LC-SC3-2018-ES-SCC, 2018)
Start date: 2019-05-01
End date: 2022-10-31
Duration (months): 42.0
Total project cost (EUR): 6858606.78
EU funding (EUR): 5935937.5
Participants: 18
Project status: SIGNED

Leading smart grid solution providers and research groups join forces to integrate a range of consumer-focused innovations into existing service platforms. The project will support Industry leaders ABB (analytical and design tools) and ATOS (energy management platform) deliver services with clear market focus, that are widely replicable across Europe. The suite of tools will be demonstrated in real-life pilots in Belgium, Greece, France and the Netherlands. RENAISSANCE aims to demonstrate highly replicable design and management approaches for integrated local energy systems, that achieve high participation of local consumers (15-20%), exceed at local level EU targets for renewable energy sources (37-80%) while decreasing the energy price for community members (5-10% below current market prices). The methodology and each of the pilots will cover key energy vectors (electricity, heat, transport), involve different actors (households, SMEs, institutions), and valorises flexibility services within and between communities, and with DSOs. In total, over 1.000 households and 50 companies will be connected in a system that totals 30752MW capacity. Main innovations include; multi-actor multi-criteria of technical design, geo-locations , interoperable management platform. To demonstrate replicability and open the role to market, the approach will be applied to 10 more locations across the globe - including in India, the US, the UK and Poland.

Keywords: smart energy communities,smart contracts,decentralisation,interoperable,replicable,global