Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Boosting immuno-oncology strategies with innovative immuno-stimulants derived from bacteria, to be administrated in combination with therapeutic monoclonal antibodies (ONCO-BOOST)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Passive immunotherapies are widely used in anti-cancer therapies. However, on average the patient response rates are still weak (20%), and the cure rate without relapse are even lesser (10%). In addition, significant differences exist according to patients, and tumor types. HEPHAISTOS-Pharma develops active and non-specific immunotherapies able to potentiate commercialized antibodies, turning cold tumors hot, thus becoming accessible to immunology. We already obtained an impressive proof of concept on two animal models, first by association with Rituximab for lymphoma, then in monotherapy for osteosarcoma. Our strategy aims at developing our products for open use, as add-on for existing immunotherapies, in order to drastically increase response rates and complete remission. With this aim, we have to test our immunotherapy combined to other monoclonal antibodies commercialized in the relevant cancer models, in parallel to our developments in lymphoma. As soon as the target indication will be defined, we will start the clinical research phase I, in order to demonstrate safety, and define the efficient dose for our immunotherapy. A clinical Phase IIa, combined with Rituximab will be performed, to obtain efficacy data. Our immunotherapy will work in synergy with numerous commercialized therapeutic antibodies, and we will look for strategic deals with the main market leaders.

Keywords: cancer,immunotherapy,monoclonal antibody immuno stimulant,natural immuno stimulants,tlr 4 ligand,non specific immune stimulation,immunotherapy combination
Local Ecologies of Knowledge: Towards a Philosophy of Ethnobiology (LOCAL KNOWLEDGE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-01-31
Duration (months): 60.0
Total project cost (EUR): 1499934.0
EU funding (EUR): 1499934.0
Participants: 1
Project status: SIGNED

Indigenous and other local communities possess complex biological knowledge that is increasingly recognized in collaborative approaches in the agricultural, environmental, and health sciences. However, collaborations between local communities and academically trained scientists are commonly challenged by deep differences in epistemologies, ontologies, and value systems. For example, an Indigenous fisher may be an expert on a local marine ecosystem but rely on spiritual fishing norms and metaphysical assumptions that raise questions about compatibility with academic ecology. This project will develop “philosophy of ethnobiology” as an interdisciplinary meeting ground for addressing foundational methodological issues in cross-cultural negotiations of biological and ecological knowledge. As there has been almost no interaction between academic philosophy and ethnobiology, the project develops an equally ambitious and original program. It provides a framework for approaching cross-cultural collaborations despite deep philosophical differences and for expanding current philosophical debates through global and applied considerations. While I am trained as a philosopher of science, the project will develop an interdisciplinary research methodology that integrates philosophical analysis and empirical collaboration with three ethnobiological research teams in Brazil and Mexico. Furthermore, I have already shown the possibility of bringing these fields together in flagship journals of both philosophy of science and ethnobiology. The unique interdisciplinary methodology and published proofs of concept therefore clearly demonstrate the feasibility of developing “philosophy of ethnobiology” as a meeting ground between foundational and applied concerns of global challenges in the life sciences.

Keywords: ethnobiology,ethnoscience,philosophy of biology,philosophy of ecology,philosophy of anthropology,traditional ecological knowledge,knowledge diversity
Functional & Dynamic 3D Nano- MicroDevices by Direct Multi-Photon Lithography (5D NanoPrinting)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Austria,Ireland,Italy,Italy,Italy,Italy,Netherlands
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-09-01
End date: 2025-02-28
Duration (months): 54.0
Total project cost (EUR): 3583800.0
EU funding (EUR): 3583800.0
Participants: 8
Project status: SIGNED

Micro & Nano Electro-Mechanical Systems (MEMS/NEMS) have a huge impact on the market in different areas ranging from consumer to automotive. Nevertheless, their real potential is largely unexplored. This because their development is a long and very expensive process, which often requires long simulation steps. Moreover, arbitrary complex 3D structures cannot be even produced with standard micro/nano-fabrication techniques. 5D NanoPrinting project aims to overcome these limitations, providing an innovative integrated technological approach, based on two-photon 3D direct printing processes. Breakthrough processes for 3D Nano- MicroDevices (NEMS/MEMS) rapid prototyping will be developed, aspiring to become a novel gold standard for micro/nano-technologies, similarly to what 3D printing represented for manufacturing technologies in the last decade. The approach will be based on new ad hoc-developed functional materials, polymerisable via two photon process, exploiting designed/tailored functional properties. In particular, to create complete NEMS/MEMS, a set of basic properties is required, including the possibility to have graded structural, patternable, conductive, and stimuli-responsive materials. Such complex functional materials, compatible with two photon lithographic process, have been not yet demonstrated; then, new suitable materials will be developed combining synthetic and nano-technological approaches. Expected innovation brought by the project will be not limited only to material science, but a great impact at levels of process and system is also expected. Respect to traditional micro/nano-fabrication technologies, the proposed one will be specifically used for: o Rapid prototyping, to test new principles and configurations before final device design o Production of 3D complex or of customizable devices (parametric devices production, e.g. multi-axial nano-force sensors) o Production of low numbers/high added value devices (e.g. cochlear implants).

Keywords: two photon lithography,direct laser writing,3d micro printing,cochlear implants,mems,nems,functional materials,smart materials,hydrogels,nanomaterials
Electron-lattice-spin correlations and many-body phenomena in 2D semiconductors and related heterostructures (FLATLAND)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-10-01
End date: 2021-09-30
Duration (months): 60.0
Total project cost (EUR): 2640632.89
EU funding (EUR): 2640632.89
Participants: 1
Project status: CLOSED

Two-dimensional crystalline materials exhibit exceptional physical properties and offer fascinating potential as fundamental building blocks for future two-dimensional electronic and optoelectronic devices. Transition metal dichalcogenides (TMDCs) are of particular interest as they show a variety of many-body phenomena and correlation effects. Key properties are: i) additional internal degrees of freedom of the electrons, described as valley pseudospin and layer pseudospin, ii) electronic many-body effects like strongly-bound excitons and trions, and iii) electron-lattice correlations like polarons. While these phenomena represent intriguing fundamental solid state physics problems, they are of great practical importance in view of the envisioned nanoscopic devices based on two-dimensional materials. The experimental research project FLATLAND will address the exotic spin-valley-layer correlations in few-layer thick TMDC crystals and TMDC-based heterostructures. The latter comprise other 2D materials, organic crystals, metals and phase change materials as second constituent. Microscopic coupling and correlation effects, both within pure materials as well as across the interface of heterostructures, will be accessed by time- and angle-resolved extreme ultraviolet-photoelectron spectroscopy, femtosecond electron diffraction, and time-resolved optical spectroscopies. The project promises unprecedented insight into the microscopic coupling mechanisms governing the performance of van der Waals-bonded devices.

Keywords: two dimensional materials,ultrafast photoelectron spectroscopy,time resolved diffraction,van der waals bonded heterostructures
Therapeutic antibody drug monitoring using bioluminescent sensors proteins and a smartphone (LUMABS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-06-01
End date: 2018-11-30
Duration (months): 18.0
Total project cost (EUR): 149750.0
EU funding (EUR): 149750.0
Participants: 1
Project status: CLOSED

Therapeutic antibodies represent an important class of newly introduced drugs and have been particularly successful in cancer therapy and the treatment of inflammatory diseases. The clearance rates of therapeutic antibodies are known to differ per individual and correlate with survival rates. Being able to define a personalized dose per patient based on continuous monitoring of therapeutic antibody levels would therefore be beneficial both for the individual patient and for the hospital’s budget. Our group recently developed a new platform of bioluminescent sensor proteins for antibody detection that allow antibody detection directly in blood plasma using the camera of a smart phone as the sole piece of equipment. The goal of this ERC Proof-of-Concept is to establish LUMABS as a unique, low cost, and easily accessible point-of-care technology for monitoring therapeutic antibodies. To enable clinical and commercial translation a product portfolio will be established that includes the development and validation of a prototype point-of-care assay for the therapeutic antibody Cetuximab. To establish LUMABS as a broadly applicable platform technology, we will use recently developed epitope screening technology to develop specific LUMABS sensors targeting Infliximab and biosimilar antibodies that are used to treat inflammatory conditions such as Crohns’ disease and rheumatoid arthritis. Based on an in-depth market analysis and the feedback we receive from external stakeholders on the performance of our technology, a realistic strategy will be developed for further translation and commercialization. During the project we will continuously assess opportunities for new patent applications. Our IP strategy will be guided by the outcome of our market examination and analysis of the most interesting business opportunities.

Keywords: point of care diagnostics,therapeutic antibodies,therapeutic drug monitoring,biosensor,bioluminescence
A unifying model: bulk chondrite complementarity by individual chondrule-matrix mentality (Complementarity)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

The so far unique role of our Solar System in the universe regarding its capacity for life raises fundamental questions about its formation history relative to exoplanetary systems. Central in this research is the accretion of asteroids and planets from a gas-rich circumstellar disk and the final distribution of their mass around the central star, our Sun. The key building blocks of the planets may be represented by chondrules, once molten silicate spherules that are the main constituents of chondritic meteorites, which in turn are primitive fragments of planetary bodies. Chondrule formation mechanism(s), as well as their subsequent storage and transport in the disk are still poorly understood and their origin and evolution can be probed through their link to unprocessed dust that accreted together with chondrules in chondrites. Contrastingly, while bulk chemical and isotope analyses of this dust (the matrix) and chondrules indicate that these components formed co-genetically in a single reservoir, individual analyses of chondrules suggest that they formed over a range of space and time, requiring storage and transport mechanisms. The candidate proposes to unify these seemingly opposing data in a single model that will result in significant and timely progress on the frontiers of Solar System research, including a bridge to astrophysical simulations that tackle planet formation and physicochemical constraints on the origin of chondrules. This model invokes bulk chondrule-matrix complementarity as a result of genetic relationships between individual chondrules and their dust rims. The necessary development of analytical methods to verify this hypothesis will contribute greatly to the advancement of small sample analyses, including cometary grains from sample return missions and interplanetary dust particles.

Keywords: cosmochemistry,meteorites,chondrules
INnovative laser machine For INdustrial engravIng and 3d TExturing (INFINITE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-2-2015, 2015)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 1833562.5
EU funding (EUR): 1282793.75
Participants: 2
Project status: CLOSED

Created 15 years ago, the innovative Italian company ML Engraving SRL is one of the leaders in laser engraving and texturing on moulds/dies and parts for automotive and consumer goods industries in one of the most industrialised regions in Europe, Lombardia. ML Engraving is also part of the partner´s alliance “Cactooos, The Engraving Network”, which gathers the best companies – ML Engraving, DS4 and 2 other Italian SMEs (Jockoo and NovaTex) – specialized in services connected to the creation and engraving and texturing on moulds. With INFINITE project, they are developing an innovative laser machine for high precision engraving and 3D surface texturing, fully adapted to these industries in terms of design requirements, productivity, repeatability, easy operability & price. This new technology will allow ML Engraving to consolidate its position in the laser engraving/texturing services (+32% services in 5 years) while extending its business – in partnership with DS4 – as laser machine supplier for these markets and other production lines industries in Europe and Worldwide (€25 million accumulated sales for 2017-2021).

Keywords: laser,engraving,etching,texture,robot,artificial vision
Last Letters from the World Wars: Forming Italian Language, Identity and Memory in Texts of Conflict (LAST_LETTERS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 175866.0
EU funding (EUR): 175866.0
Participants: 1
Project status: CLOSED

What are the final wishes of those who are about to die, in a period of war? Can we identify patterns in wartime letter writing in the context of the two World Wars? The proposed research project consists of a thematic and linguistic analysis of the last letters of Italians sentenced to death during the two world wars. These letters are an invaluable testimony of the changes that occurred in Italian society when the Italian Republic was born, after the fall of Totalitarianism. These missives are the most illuminating tokens of a turning point in Italian language, politics, gender perception and culture. Indeed, they describe the advent of Italian as a national language, born of a mixture of several registers and regional traits. Furthermore, anti-war ideas, laying the foundations of the Italian constitution, are clearly expressed in the last words of most writers, who wanted to leave their political convictions as a legacy for the future of the country. Moreover, these letters demonstrate a deep change in traditional gender distinctions, as they expose new conceptions of the family during wartime – considering that the majority of these letters was sent to the writers’ next of kin. The purpose of the study is to interpret these last letters through the lens of new gender, identity, and conflict theories, categorising and arranging the searchability of these texts via digital technologies to make them available to the wider public. The research is supported by Europeana14-18 and the Italian Institute for the History of the Resistance, and is hosted by University College Cork. It is supervised by Dr Silvia Ross, Senior Lecturer in Italian, with an international research record in contemporary Italian literature and particular interests in gender, identity, alterity and conflict. The Researcher has also secured targeted international secondments with two other partners (U of Reading and the Italian Central Archive) and one external partnership (NYU).

Keywords: letters,gender,conflict,language,identity
An Implantable Peritoneal Ultrafiltration Device that actively and continuously prevents fluid overload in congestive heart failure patients (IPUD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-08-01
End date: 2022-07-31
Duration (months): 36.0
Total project cost (EUR): 2957025.48
EU funding (EUR): 2036849.5
Participants: 1
Project status: CLOSED

Pathologic fluid overload (congestion) is a medical condition when high volume of fluid (water) accumulates in the body leading to congestive heart failure (CHF). CHF is a severe global health problem affecting each year ~26 million people worldwide, of which 8 million are chronic and diuretic resistant patients. Current solutions for fluid overload in diuretic resistant patients such as infusion pump for intravenous (IV) diuresis, catheter-based device for ultrafiltration therapy and peritoneal dialysis all carry complications and are acute treatments which do not prevent recurrence. Paragate developed IPUD a unique implantable peritoneal ultrafiltration system for continuous monitoring and removal of extracellular fluids in CHF patients. It is minimally invasive (laparoscopic approach) and continuously (24/7) and slowly absorbs systemic isotonic extracellular fluid and drains it to the urinary system preventing recurred accumulation. In addition, IPUD guarantees a continuous monitoring of the fluid as well as the urinary system function thanks to a sensing system (embedded into the implantable system) and a treatment management platform. In this way, physicians have a direct control of the treatment and patient’s condition. The controlled, moderate non-aggressive fluid removal eliminates the main complications associated with the acute and aggressive treatments that lead to hemodynamic shock, worsening of renal function, arrhythmia and metabolic instability. Thanks to IPUD, patients will improve their quality of life eliminating frequent hospitalizations with a more effective treatment and healthcare systems will significantly reduce the €100 billion/year cost for frequent hospitalizations and treatment costs. The Phase 2 project will enable Paragate to scale-up production, perform validation and verification activities including a preclinical study; and validate the safety and efficacy of IPUD in a pilot clinical trial.

Keywords: congestive heart failure,continuous fluid congestion removal,ultrafiltration device,minimally invasive,management platform