Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Multiple-actOrs Virtual Empathic CARgiver for the Elder (MoveCare)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Italy,Spain,Spain,Spain,Cyprus,Sweden,Sweden,Sweden,Slovenia,France,United Kingdom,United Kingdom,United Kingdom
Call: System abilities, development and pilot installations (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2020-03-31
Duration (months): 39.0
Total project cost (EUR): 5933611.25
EU funding (EUR): 5933611.25
Participants: 18
Project status: CLOSED

MoveCare develops and field tests an innovative multi-actor platform that supports the independent living of the elder at home by monitoring, assist and promoting activities to counteract decline and social exclusion. It comprises 3 hierarchical layers: 1) A service layer provides monitoring and intervention. It endows objects of everyday use with advanced processing capabilities and integrates them in a distributed pervasive monitoring system to derive degradation indexes linked to decline. 2) A context-aware Virtual Caregiver, embodied into a service robot, is the core layer. It uses artificial intelligence and machine learning to propose to the elder a personalized mix of physical/cognitive/social activities as exergames. It evaluates the elder status, detects risky conditions, sends alerts and assists in critical tasks, in therapy and diet adherence. 3) The users’ community strongly promotes socialization acting as a bridge towards the elders’ ecosystem: other elders, clinicians, caregivers and family. Gamification glues together monitoring, lifestyle, activities and assistance inside a motivating and rewarding experience. Off-the-shelf components are assembled in a robust and reliable way to get a low-cost multi-actor IP-domotic platform that can be massively deployed at elders home. The use of software/hardware standards assures interoperability and makes MoveCare adaptable to utmost novel components. Full configurability, personalization, adaptation to elder needs applies to all components to maximize elder compliance, even when computer illiterate. On-field testing starting early in the project assures an implementation iterative approach involving all actors. MoveCare identifies functional and technical metrics to characterize and evaluate the system by means of improvement in its abilities as described by the Multi-Annual Roadmap. The metrics lead to the definition of an evaluation framework transferrable to other fields

Keywords: multi actor system evaluation,autonomous robot navigation,active vision,slam,machine learning and artificial intelligence,smart objects,embedded sensors,exer gaming,gamification,ip domotics
To-Euro-5G: Supporting the European 5G Initiative (To-Euro-5G)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Partnership: 5G PPP (cPPP)
Countries involved: Ireland,Italy,Germany,Germany,Belgium,Norway,Switzerland,France,France,France,France,United Kingdom
Call: 5G PPP Research and Validation of critical technologies and systems (H2020-ICT-2016-2, 2016)
Start date: 2017-06-01
End date: 2019-08-31
Duration (months): 27.0
Total project cost (EUR): 2522708.75
EU funding (EUR): 2522708.75
Participants: 13
Project status: CLOSED

The To-Euro-5G project has a clear objective to support the activities of the European 5G Initiative as outlined in the 5G contractual Public Private Partnership (cPPP) during the second phase of the 5G-PPP from June 2017 to June 2019, with the intention of maximising the return on this investment for Europe. . The objectives of To-Euro-5G include: • Progressing the 5G-PPP high level goal of maintaining and enhancing the competitiveness of the European ICT industry, and seeking European leadership in the 5G domain. • Supporting activities where the 5G-PPP can contribute to the implementation of the European 5G Action Plan . • Assembling an overview of the 5G-PPP projects trial/demo/showcase potential and encouraging any organisation performing such an activity to identify the “European 5G” basis of their public showcases. • Responsibility for orchestrating the cross project activities of the 5G-PPP projects selected for Phase 2 of the 5G-PPP, as foreseen by Article 41.4 of their respective grant agreements, for example, in the areas of Standards, Spectrum, Architecture, management, Security and a number of other key strategic aspects of 5G. • Developing and implementing a strategic communications plan, including technical and social media channels, to ensure the best possible impact is achieved with the results of the 5G-PPP projects and the horizontal activities of the 5G-PPP programme. • Stimulating, organising and hosting strategic events and workshops where the European 5G achievements will be promoted on a global level. • Orchestrating an open, transparent and flexible 5G-PPP programme governance structure that facilitates good co-operation between the projects, the commission and the 5G Infrastructure Association. . The To-Euro-5G project also has the underlying ambition to ensure that European society, via the Vertical sectors uptake of 5G, can enjoy the economic and societal benefits these future 5G networks can provide.

Keywords: 5g ppp,networks,radio interface,fronthaul,backhaul,architecture,infrastructure
Applying human lung tissue models to develop a personalised treatment for critically ill (ALGORITM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Acute respiratory distress syndrome (ARDS) is a major cause of mortality in the critically ill patients with no effective pharmacological treatment. Recently, two distinct endotypes of ARDS were identified and validated in four large randomized controlled trials: a hyper-inflammatory and a hypo-inflammatory endotype. These endotypes have strikingly different clinical characteristics, biomarker profiles, clinical outcomes, and treatment responses. While these data are highly promising, the biology of these endotypes is not understood. Mesenchymal Stem Cells (MSCs) hold significant therapeutic promise for ARDS and are rapidly progressing to clinical trials across the world. However, concern for the use of stem cells, specifically the risk of tumor formation, remains unresolved. Accumulating evidence suggests that MSCs exert their therapeutic benefit through the release of extracellular vesicles (EVs). MSC EVs are being actively developed as a cell free therapy for ARDS, but for the effective clinical translation it is important to establish EV therapeutic potential for both biological endotypes of patients. In this project, I am going to use cutting edge technology and employ the most physiological human lung tissue models to date to study the biology of ARDS endotypes and to test therapeutic potential of MSC EVs. The main objectives are: i) To reveal how endotype–specific environments alter human lung tissue and how these changes are affected by EV treatment at a single cell level, using single cell RNA-Seq transcriptomic profiling of precision-cut human lung tissue slices, ii) to study how endotype-specific environments (with or without EV treatment) alter functional properties of the alveolar epithelial-endothelial barrier using lung-on-a-chip microfluidic model, iii) to study how endotype-specific environments (with or without EVs) alter metabolism of the primary human pulmonary cells involved in ARDS pathophysiology using Seahorse Metabolic Analyser.

Keywords: acute respiratory distress syndrome,mesenchymal stem cells,extracellular vesicles,human lung tissue models,regenerative medicine
The Mexican leech Haementeria officinalis and its nutritional symbiont as a model system for the study of strict blood-feeding animal-microbe symbioses and bacteriocyte development (LEECHSYMBIO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-15
End date: 2023-08-11
Duration (months): 24.0
Total project cost (EUR): 186167.04
EU funding (EUR): 186167.04
Participants: 1
Project status: SIGNED

Strict blood-feeding leeches are confronted with a strong B-vitamin deficiency and thus rely on bacterial symbionts to supplement their unbalanced diet. Recent evidence showed that the Mexican leech Haementeria officinalis houses in a distinct specialised organ intracellular Providencia siddallii symbionts, which have a highly reduced genome but maintained genes required for B vitamin biosynthesis. The aim of this proposal is to establish this leech as a model system for studying the intricacies of nutritional blood-feeding symbioses. The genomes of Providencia symbionts of 4 additional Haementeria species will be sequenced and analysed to identify core-metabolic pathways and to reconstruct the evolutionary history of this symbiosis. A draft genome sequence of the Mexican leech Ha. officinalis will be determined, providing unique insights into metabolic complementarity. Comparison with the available genome of the related non-blood-feeding leech Helobdella robusta will facilitate identification of genomic determinants of the acquisition/loss of the bacteriome and the blood feeding habit. Bacteriome development and colonization will be investigated using different developmental stages and advanced microscopy techniques. Host control and nutritional role of the symbiont will be studied using isotope probing experiments and state-of-the-art chemical imaging and metabolomics methods. This project will provide comprehensive insights into a nutritional symbiosis in medically relevant blood-feeding animals, including the evolution of specialised symbiosis organs and metabolic interactions between both partners. It will bring together a postdoc with a strong background in bioinformatics and bacterial symbionts with a host lab focused on experimental and molecular analysis of microbe-host interactions. This set-up ensures both an ideal environment for the postdoc on his way to an truly independent researcher, and an efficient two-way transfer of knowledge.

Keywords: leech symbiosis,b vitamin production,host microbe interactions,bacteriome development,blood,feeding parasite
Towards local circular economy: biomass-based pyrogasification process for the production of green hydrogen (Hydrogreen)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-11-01
End date: 2019-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Hydrogen is meant to be one of the most important renewable energy sources of the future since it is a flexible energy carrier that will facilitate significant reductions in energy-related CO2 emissions, what would favour to meet requirements of EU energy policies and fight against climate change. However, it is necessary to overcome infrastructure challenges and high productive cost to achieve a competitive alternative to other renewable energies. T’AIR ENERGIES is a French SME which aims at bringing to market an innovative energetic model where the local biomass and waste are valorised to produce and distribute green hydrogen for mobility (fuel cell electric cars), energy (electricity/gas) and industrial applications. Our innovative solution, called Hydrogreen, is a pyrogasification-based process where biomass (wood, wood waste, straw) is converted, with optimum efficiency, into energetic hydrogen and decarbonated CO2. Our methodology proposes an integral process based on the valorisation of locally available material and agricultural surpluses through a decentralized process that guarantees huge savings in terms of logistical costs (-66%) for the system's inputs. In addition, thanks to the optimization of the resources used and the introduction of waste/products at the end of their life in the productive cycle, it is fully aligned with the principles of the circular economy. Finally, the distribution of H2, in which the traditional service stations are complemented with a personalized system where our logistics partners directly transport the fuel to the end users, solves a key mobility bottleneck, further boosting the growth of the number of vehicles based on clean hydrogen energy. As Hydrogreen will enable us to offer green hydrogen to local actors at a competitive price below €7/kg, we expect, after 5 years of exploitation to reach €25 million revenues, with 4 industrial sites commissioned and +88 new employees.

Keywords: hydrogen production,green hydrogen,pyrogasification,biomass feedstock,circular economy,energy valorisation,decentralisation,local fuelling service,straw surpluses,rural revitalisation
Cancer heterogeneity and therapy profiling using bioresponsive nanohydrogels for the delivery of multicolor logic genetic circuits. (GelGeneCircuit)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Portugal
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-02-01
End date: 2025-01-31
Duration (months): 60.0
Total project cost (EUR): 1435312.0
EU funding (EUR): 1435312.0
Participants: 2
Project status: SIGNED

Conventional cancer therapies suffer from poor efficacy owing to the lack of efficient delivery systems and to the inherent tumor heterogeneity that requires multi-modal approach to abrogate cancer progression. Nanotechnology holds promise to address these drawbacks, as the use of (bio)nanomaterials for diagnostics and therapy has been gaining momentum over the last years. The main goal of this project is to develop a novel and facile platform capable of profiling both the therapy outcome and heterogeneity in cancer, by using bioresponsive nanohydrogels for the delivery of logic multicolor synthetic gene circuits. These logic synthetic gene circuits will be designed as a biobarcode of multicolor RNA circuits embedded in hybrid nanoparticles and doped in hydrogels for local therapy in breast cancer in vivo. Using cell-type specific promoters, the multicolor miRNA circuits will be expressed specifically to each type of the cells of the tumor microenvironment. Subsequently, this will permit to evaluate the therapeutic efficacy in a cell-by-cell basis and to profile the tumor heterogeneity across different breast cancer types. In order to potentiate the translation of this ground-breaking platform into clinics and precision medicine, novel de-regulated miRNA targets will be identified based on screens performed in breast cancer patient-derived tumors that better reflect the heterogeneous tumor microenvironment in a patient-by-patient basis. In sum, the material platforms developed herein and newly identified biological targets can be harnessed to design effective cancer treatments that go beyond breast cancer. The project is highly versatile and multidisciplinary and this system can be easily adapted to target any cancer cell type and molecular mechanisms and translated to clinical testing.

Keywords: cancer,nanotechnology,tumor microenvironment,tumor heterogeneity,biomaterials,micrornas,gene therapy,nanoparticles
Targeted complete next-generation sequencing for companion diagnostics and personalized treatment of cancer (SEQURE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Biotechnology
Action type: SME instrument
Countries involved: Netherlands
Call: Dedicated support to biotechnology SMEs closing the gap from lab to market (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 1851000.0
EU funding (EUR): 1295700.0
Participants: 1
Project status: CLOSED

Next-generation sequencing (NGS)-based genetic tests are at the forefront of the adoption of personalized medicine in cancer. However, current tests rely on the sequencing of short fragments covering only a fraction of the complete sequence of genes of interest. By missing clinically relevant genetic variants, including structural changes such as gene fusions, genetic diagnostics for personalized medicine is suboptimal and ineffective. There is therefore an unmet need for a cost-effective technology, providing the complete sequence information and enabling detection of all genetic variants relevant for therapeutic decisions. Dutch biotechnology company Cergentis has developed the proprietary TLA (Targeted Locus Amplification) sequencing technology platform, enabling targeted NGS sequencing of complete genes, across all gene regions (exons and introns) and all types of genetic variants (including structural changes) in a single rapid analytical procedure. Cergentis seeks to finalize the platform development for the analysis of tumor biopsies and validate customizable companion diagnostic kit, that will be offered to pharmaceutical companies to improve effectiveness of drug development in oncology clinical trials. Company will perform validation of a dedicated in-vitro companion diagnostic BRCA SEQURE kit, markedly improving diagnosis and personalized treatment of breast and ovarian cancer. The project will position Cergentis’ technology for a co-licensing agreement with a global diagnostic/pharmaceutical company to ensure effective large scale clinical implementation of the TLA-based in-vitro companion diagnostic kits. By closing the gap from lab to market, SEQURE project will accelerate the commercialization of a unique diagnostic technology answering an unmet need in the personalized treatment of oncologic disorders. The project will also realize a strategic move of a high growth potential biotechnology SME to the attractive genetic diagnostic market.

Keywords: next generation sequencing,companion genetic diagnostics,in vitro diagnostic kit,oncology,breast and ovarian cancer,personalized medicine,gene fusions,minimal residual disease tests
Collaborative Engagement on Societal Issues (COESO)

Framework: Horizon 2020 — Science with and for Society
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Spain,Italy,Italy,Belgium,France,France,France,France,Portugal
Call: Hands-on citizen science and frugal innovation (H2020-SwafS-2020-1, 2020)
Start date: 2021-01-01
End date: 2023-12-31
Duration (months): 36.0
Total project cost (EUR): 2193418.75
EU funding (EUR): 2193418.75
Participants: 16
Project status: SIGNED

The COESO (Collaborative Engagement on Societal Issues) project facilitates and supports participatory research in SSH, through a service-first approach. COESO supports ten Citizen Science pilots presenting a variety of disciplines, societal challenges and types of engagement with citizens in different European countries. COESO project will specifically support collaborative practices in Citizen Science by developing a Virtual Ecosystem for Research Activation (VERA), a platform envisioned as a "collaboratory” providing a set of tools to discover potential partners, to define and co-design the activities, to co-create new knowledge and solutions, and to deliver them to society. COESO will furthermore collaborate with research funding organizations to enhance financial support to Citizen Science projects in the SSH and explore the frontiers of innovation in SSH public engagement by achieving a complete mutual learning with the teams involved in the Pilots. Finally, “Cooperation analytics” will be designed to measure the quality of collaboration between researchers and citizens in VERA. Those analytics will be useful to the project teams themselves but they will also be a major contribution to funders, policy makers, research organizations and other stakeholders supporting Citizen Science policies. COESO’s overall objective is to overcome the obstacles that hinder the development of Citizen Science in the SSH. COESO will enable a dramatic growth of Citizen Science projects in these disciplines and will intensify the collaborations between SSH researchers and citizens to tackle together the many societal challenges European societies face today. VERA will be one of the core services offered by OPERAS Research Infrastructure to the scientific community.

Keywords: citizen science,open science,social sciences and the humanities
Innovative indicators of resilience to protect the health status of seagrass meadows: from ecological theory to conservation (HEALSEA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-09
End date: 2020-10-11
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Seagrasses are key ecosystem engineers that create structurally complex habitats in coastal areas, thereby increasing biodiversity and providing important ecosystem services. Their documented and worldwide loss calls for effective conservation measures. Our capacity to succeed in this task largely depends on our aptitude to anticipate their decline. Ecological theory and some evidence suggest that seagrass loss is often sudden, and cannot be predicted without exactly knowing the trajectory of their response to increasing stress or their behaviour before and after decline. Ecological theory also proposes that systems close to decline become more stochastic and slow in recovering from disturbance, a phenomenon known as critical slowing down. Such theory can be applied to complex ecological systems, providing appropriate experimental tests on suitable signals of this phenomenon, called indicators of resilience. Yet, knowledge on seagrass response patterns and the identification of these theoretical indicators of resilience is lacking. By means of a field manipulative experiment and model simulation based on literature and experimental data, the proposed research aims at (1) identifying what are the response patterns of seagrass traits to a gradient of stress; and (2) testing for the existence of indicators of resilience in seagrasses. In addition, the project will (3) implement the results into a protocol of action to be used by practitioners as innovative tools to anticipate potential changes in seagrass resilience. The development of this project will contribute significantly to seagrass conservation using an innovative approach that combines experimental work with ecological theories and modeling.

Keywords: seagrass,experimental ecology,indicators of resilience,stress,disturbance