Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Investigating macrophage-nerve crosstalk in homeostasis and post-stroke spontaneous urinary tract infection (neUTIbladder)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 2
Project status: SIGNED

UTI is one of the most common bacterial infections, affecting >150 million individuals annually, worldwide. Unexpectedly, UTI is also the most common complication after stroke, occurring in up to 40% of patients. This suggests a dysregulation between the bladder and the brain, however this has never been studied. In other mucosal organs, neurons are in direct contact with tissue-resident macrophages and modulate their function during infection. Indeed, stroke causes striking changes to the immune compartment, including macrophages, in peripheral organs. As a result, stroke patients experience increased susceptibility to infection, alongside systemic inflammation, which is associated with neurological decline. In this project, I will investigate bladder macrophages in homeostasis and during acute stroke recovery. I will assess the impact of stroke on bladder immune cell-nerve crosstalk, including bladder macrophages and susceptibility to UTI. Specifically, I hypothesize that changes in macrophage-nerve crosstalk after stroke alters macrophage response to infection, leading to systemic inflammation and subsequent neurological decline. In collaboration with The University of Edinburgh, I will use a model of ischemic stroke in the lab of Dr Laura McCulloch to test this hypothesis. During this project, I will use state-of-the-art technologies such as spatial transcriptomics, 3D-imaging and spectral flow cytometry. Training at the University of Edinburgh, alongside in the host lab, will provide me with a unique set of skills combining the disciplines of immunology, microbiology and neurobiology. The expertise I will acquire in this project are in line with my career goals to become an independent researcher, and provide me with the tools to address a novel question in a largely unstudied area with clinical importance.

Keywords: macrophage,nerve,neuroinflammation,stroke,urinary tract infection,sex difference
Fostering Outermost regions Capabilities in Research and Innovation and Upgrading Skills complying with 4R principles (FOCUS-4R)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Portugal,Spain,France,Norway,Netherlands
Call: ERA Talents (HORIZON-WIDERA-2024-TALENTS-03, 2024)
Start date: 2025-09-01
End date: 2029-08-31
Duration (months): 48.0
Total project cost (EUR): 2999893.75
EU funding (EUR): 2999893.75
Participants: 12
Project status: SIGNED

The EU outermost regions (ORs) face unique challenges and opportunities in the biomedical sector due to their geographical remoteness, insularity, and specific socio-economic conditions. Despite significant R&I initiatives in the past years, which hold great potential to address the health challenges faced by these ORs, the creation of new businesses and jobs remains low. In addition, the lack of specialized biomedical researchers and innovators hampers the ability of ORs to conduct cutting-edge research. FOCUS-4R aims to enhance the R&I capacities of the ORs, helping them to gain autonomy, competitiveness, and attractiveness in the biomedical field. The FOCUS-4R project brings together 3 emblematic ORs (Reunion Island, Canary Islands and Madeira) to leverage the expertise they have developed over recent years to create growth opportunities and increase the excellence of their institutions. Bringing together an intersectoral and interdisciplinary network of 6 academic institutions and 5 non-academic partners from 4 Widening regions and 4 Advanced countries, the project will offer cross-sectoral training and talent mobility through secondments and workshops. FOCUS-4R aims to develop a relevant path to assess therapeutic effects of molecules rapidly and at a low cost without ignoring the ethical issues by focusing on identified techniques that meet the principles of 4R (Replacement, Reduction, Refinement and Responsibility). Through training and mentoring from advanced partners, FOCUS-4R will develop transferable skills essential to meet the industrial and market needs and enhance entrepreneurship in the ORs. By providing training, lifelong learning opportunities and by consolidating knowledge transfer, FOCUS-4R will contribute to bridge the gap between ORs and advanced regions, developing long-lasting collaborations, creating new employment and career opportunities and leading to the creation of a sustainable R&I ecosystem fostering Excellence and Innovation.

Keywords: outermost regions,widening advanced network,cross sectoral mobility,4rs principles,entrepreneurship,biomedical ecosystem,animal welfare,lifelong learning,brain circulation,employability
AI powered Data Curation & Publishing Virtual Assistant (AIDAVA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Netherlands,Belgium,Germany,Bulgaria,Switzerland,Austria,Estonia,Romania,Spain,Croatia
Call: Innovative tools for use and re-use of health data (in particular of electronic health records and/or patient registries) (HORIZON-HLTH-2021-TOOL-06, 2021)
Start date: 2022-09-01
End date: 2026-08-31
Duration (months): 48.0
Total project cost (EUR): 7720615.23
EU funding (EUR): 7720615.0
Participants: 16
Project status: SIGNED

Integrated, high-quality personal health data (PHD) represents a potential wealth of knowledge for healthcare systems, but there is no reliable conduit for this data to become interoperable, AI-ready and reuse-ready at scale across institutions, at national and EU level. AIDAVA will fill this gap by prototyping and testing an AI-powered, virtual assistant maximizing automation of data curation & publishing of unstructured and structured, heterogeneous data. The assistant includes a backend with a library of AI-based data curation tools and a frontend based on human-AI interaction modules that will help users when automation is not possible, while adapting to users? preferences. The interdisciplinary team of the consortium will develop and test two versions of this virtual assistant with hospitals and emerging personal data intermediaries, around breast cancer patient registries and longitudinal health records for cardio-vascular patients, in three languages. The team will work around four technology pillars: 1) automation of quality enhancement and FAIRification of collected health data, in compliance with EU data privacy; 2) knowledge graphs with ontology-based standards as universal representation, to increase interoperability and portability; 3) deep learning for information extraction from narrative content; and 4) AI-generated explanations during the process to increase users? confidence. By increasing automation of data quality enhancement, AIDAVA will decrease the workload of clinical data stewards; by providing high-quality data, AIDAVA will improve the effectiveness of clinical care and support clinical research. In the long-term, AIDAVA has the potential to democratise participation in data curation & publishing by citizens/patients leading to overall savings in health care costs (through disease prevention, early diagnosis, personalized medicine) and supporting delivery of the European Health Data Space.

Keywords: patient centricity,data intermediaries,intelligent virtual assistant,personal health knowledge graph,explainability and trustworthiness,deep learning nlp and machine learning models,data curation
Measuring U-Space Social and Environmental Impact (MUSE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Spain,Serbia,Belgium,France
Call: Fundamental Science and Outreach for U-space and Urban Air Mobility (HORIZON-SESAR-2022-DES-ER-01, 2022)
Start date: 2023-06-01
End date: 2025-11-30
Duration (months): 30.0
Total project cost (EUR): 999731.25
EU funding (EUR): 999731.25
Participants: 6
Project status: SIGNED

The goal of MUSE is to develop a set of key performance indicators, methods and tools for the comprehensive and rigorous assessment of the impact of UAM operations on the liveability and quality of life in European cities, with particular focus on drone-generated noise and visual pollution. This general goal translates into the following specific objectives: 1. To define a set of U-Space social and environmental KPIs able to capture the full range of UAM's impacts on citizens’ quality of life with the highest possible level of geographical, temporal, demographic, socioeconomic and behavioural resolution 2. To develop new methods and tools for the measurement and forecasting of the proposed KPIs. The new toolset will provide accurate drone 4D trajectory generation in urban areas, modelling of UAM’s noise and visual footprints, high-resolution dynamic population mapping and calculation of population exposure indicators segmented by type of day and time of the day, citizens’ sociodemographic profile, type of activity being performed and other relevant variables. 3. To showcase and evaluate the capabilities of the new methods and tools developed by MUSE through their application to a set of case studies in one or more European cities. 4. To create the conditions for the transfer of the project results to the subsequent stages of the R&I cycle by outlining a new SESAR Solution, the MUSE U-Space Environmental and Social Impact Assessment Framework, that serves as an enabler of a future U-Space service aimed at optimising the social and environmental performance of UAM operations.

Keywords: u space,urban air mobility,social acceptance,environmental impact,performance framework,noise,visual pollution,safety,privacy
Green Aviation – Lean Arrivals And Dynamicity (GALAAD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Italy,Czechia,France,Germany,Belgium
Call: Industrial Research & Validation for Aviation Green Deal (HORIZON-SESAR-2022-DES-IR-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 7075172.5
EU funding (EUR): 3848817.01
Participants: 10
Project status: SIGNED

The GALAAD “Green Aviation – Lean Arrivals And Dynamicity” project proposal contributes to the SESAR 3 IR Aviation Green Deal topic. The project proposes to develop and validate a concept for dynamic RNP route allocation in the terminal area in order to make ATC operations more sustainable, resilient, responsive and adaptative towards operational condition changes and traffic demand variations. The research addresses the development of the end-to-end concept, including relevant decision support tools evolution and cross-border aspects. The idea is to move away from fixed RNP arrival route stuctures towards a flexible approach able to provide agile responses to variations of operational conditions in the terminal area, such as traffic density, airspace availability or environmental/weather constraints, and to develop the best eco-friendly routes structures. As operational improvements, the introduction of the GALAAD-proposed concept related to a dynamicity in the use of RNP route structures within the terminal area is expected to provide greater fuel efficiency and environmental sustainability without negatively impacting capacity while improving safety and cost efficiency.

Keywords: green,rnp,sustainability,aman,dynamicity,digital,resilience,aviation,sesar
FInding ExoeaRths: tackling the ChallengEs of stellar activity (FIERCE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Portugal
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2458705.0
EU funding (EUR): 2458705.0
Participants: 3
Project status: SIGNED

FIERCE aims at providing the long-needed step forward to tackle the challenges of stellar activity on the search for Exoearths. The detection and characterisation of other Earths, planets with the physical conditions to hold liquid water and thus potential life-sustaining environments, is a bold objective of present day astrophysics. This goal continuously pushes the development of new ground- and space-based instrumentation. However, the quest for other Earths is severely limited by astrophysical ``noise'' from the host stars, whose signatures distort the spectra that are used to detect and characterise them. Existing methods usually circumvent the problem without a detailed understanding of the individual sources of variability. This is insufficient to reach the required precision levels. To enable the full scientific success of major exoplanet research facilities a new approach is clearly needed. With FIERCE, the PI will employ his competitive team, together with the strong participation in cutting-edge ESO and ESA projects and missions, to break through in this obstacle. The ultimate goal is to i) develop novel approaches to identify, model, and correct stellar spurious signals in radial velocity measurements down to 10 cm/s, and ii) obtain a comprehensive understanding of the impact of stellar granulation and activity on the detection of exoplanet atmospheres. To this end, FIERCE will approach the problem of stellar ``noise'' from a whole new angle, building a dedicated facility, the Paranal solar Espresso Telescope (PoET). PoET will connect to the recently commissioned ESPRESSO spectrograph and, using the Sun as a proxy, allow to unambiguously identify and understand the sources of relevant variability in solar-type stars. Ambitious, timely, and feasible, this project will provide crucial information for the success of present and future major efforts aiming at detecting and characterising other Earths.
Improving Peptide-Based Anti-Cancer Vaccines with Phosphatase Inhibitors (PhosPepPres)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-08-01
End date: 2025-01-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Peptides have great potential for vaccines. Peptide-based vaccines aim to increase the population and activity of pathogen/cancer-recognizing T cells by administering antigenic peptides carrying epitopes for major histocompatibility (MHC) class I and II. These peptides are endocytosed by dendritic cells (DCs), followed by intracellular proteolytic processing to release the epitopes, the loading of the epitopes on MHC, and finally the presentation to antigen-specific T cells. Despite numerous studies showing immunogenicity in preclinical settings, peptide-based vaccines have failed to show efficacy in clinical trials. One reason for this limited efficacy is that too low amounts of epitopes are presented on MHC. Thus, one way to improve peptide-based vaccines is to improve their intracellular processing for MHC presentation by DCs. In this project, we will explore a novel approach for increasing the cross-presentation efficiency. Moreover, we will perform pre-commercialization studies aimed at protecting the intellectual property, defining the commercialization strategy, and enhancing our industrial network. We expect that our strategy will raise interest, as many pharmaceutical companies are developing peptide-based vaccines.
ANTI-GENDER BACKLASH & DEMOCRATIC PUSHBACK (PushBackLash)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Democracy and Governance
Action type: Research and Innovation actions
Countries involved: Austria,Netherlands,United Kingdom,Germany,Hungary,Belgium,Spain,Poland
Call: Feminisms for a new age of democracy (HORIZON-CL2-2021-DEMOCRACY-01, 2021)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2168131.25
EU funding (EUR): 2158756.0
Participants: 11
Project status: SIGNED

The goal of PUSH*BACK*LASH is twofold: (1) Firstly, to systematically inquire into the present-day contestation of gender equality issues and policies at both elite and citizen levels. Approaching democracy from a global feminist perspective, we employ a rigorous, comparative, multi-method design (e.g., experiments, surveys, interviews, participatory theatre). Our project enables: (a) identifying anti-gender strategies as well as best practices in counter-acting them across space and time; and (b) assessing the effects of anti-gender discourses by focusing on parties, social media and the public opinion. Secondly, to (2) develop and test strategies that can effectively counteract anti-gender and anti-feminist discursive strategies. Aiming at supporting the quality of democratic governance in more inclusive European societies, we acknowledge intersections between gender and other social categories at all stages of the project (composition of consortium and advisory board; theory formulation, empirical investigation, and policy recommendations) and thus engage with stakeholders. To develop sustainable solutions, we bring together gender activists, EU experts and researchers from several fields of political science (political theory, public policy, political parties, public opinion, political behavior), anthropology, communication and media, philosophy, sociology and social psychology. PUSH*BACK*LASH is a transdisciplinary, gender-diverse consortium aiming at equipping pro-equality actors with practical toolkits for responding to anti-gender equality and anti-feminist discursive strategies and backlash tactics.

Keywords: engendering democracy,intersectionality,inclusive feminism,countering anti gender discourse,multimethod
Searching New Physics using Flavour (SNPF)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 210789.12
EU funding (EUR): 210789.12
Participants: 1
Project status: SIGNED

After ten years from the discovery of the Higgs boson at CERN, which established the Standard Model (SM) of particle physics as the most accurate description of nature at its fundamental level, no direct sign of new physics (NP) beyond the SM has been observed. In order to make further progress in high-energy physics, it is necessary to improve the precision of theoretical SM predictions and search NP effects indirectly by looking for tiny discrepancies with experimental measurements. This proposal will make use of a combination of formal and numerical tools, in particular methods of numerical lattice quantum chromodynamics (QCD), to achieve this aim in the context of flavour physics. Two projects are proposed, which have the common goal of improving the precision on theoretical predictions of relevant flavour observables and share the difficulty of being dominated by hadronic effects that require non-perturbative lattice calculations. In the first project, I will study the leading electromagnetic and strong isospin breaking corrections to kaon semi-leptonic decays, providing a method to extract the relevant decay amplitudes from finite-volume (FV) Euclidean correlation functions evaluated on the lattice and computing analytically their FV dependence. This aims to determine the CKM matrix element Vus with sub-percent precision and hence to test the CKM matrix unitarity predicted by the SM. The goal of the second project is instead to obtain a first non-perturbative estimate of long-distance contributions to the mixing of neutral D mesons, which are dominant but poorly known, thus representing a limiting factor in the study of CP violation and NP effects in this process. This will be done by applying advanced reconstruction techniques to FV lattice spectral functions. This proposal will have a relevant impact on flavour physics and phenomenology, delivering new conceptual and algorithmic methods which will provide the foundations for future scientific progress.

Keywords: theoretical physics,lattice field theory,lattice qcd,flavour physics,qed,meson mixing,scientific computing