Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The next generation of green, resilient and socially inclusive smart cities (ReGreeneration)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: France,Spain,Romania,Ireland,Belgium,Italy,Slovenia,Finland,Estonia,Portugal,Denmark,Netherlands
Call: Urban greening and re-naturing for urban regeneration, resilience and climate neutrality (HORIZON-MISS-2023-CLIMA-CITIES-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 10819307.32
EU funding (EUR): 9999358.63
Participants: 27
Project status: SIGNED

ReGreeneration is a public-private consortium including 9 European cities that will design & experiment together for 4 years Nature Based Solutions to regenerate deprived neighbourhoods for climate resilience, GES reduction and local ecosystem dynamization through participative methods. A set of mixed skills, covering architecture, landscape design, geomatics and digital twins, project value modelling, urbanism, nature & public space facilities, sociology, economics will be deployed in different projects in Paris (FR), Barcelona (ES), Alverca (PT), Bucharest (RO), followed by replicators located in Roma (IT), Gent (BE), Ljubljana (SL), Segrate (IT), Lappeeranta (FI). Projects are complementary and will contribute to create a replicable knowledge on a large set of cities’ challenges: - How to regenerate quality of life, health and attractiveness in marginalized areas (Bucharest, Paris) - How to capture carbon, create freshness Islands, preserve biodiversity, make a better usage of water, develop low carbon mobility & continuity, prepare resilience to stressed weather events (Alverca, Barcelona, Paris) - How to educate and make local actors (inhabitants, municipality agents, local businesses, political authorities) participate to design & maintain the green areas created ? (the nine cities) - How to analyze the diversity of local contexts to choose the right best practices to replicate in a european territory, and define the required investment & governance model ? (Roma, Gent, Ljubljana, Segrate, Lappeeranta) The knowledge to successfully create for meeting these challenges will focus on some key concepts: 1) Creation of an in-depth territory analysis unifying multiple planning domains and able to simulate evolution scenarios; 2) Extensive use of 15 Mn methodology and pedestrian/green mobility focus to support life quality and impacts analysis; 3) Permanent integration of local climate resilience challenges at each key milestones of the project.
STOP SPREAD BAD BUGS: novel antimicrobial approaches to combat multidrug resistance in bacteria (STOP SPREAD BAD BUGS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands,Ireland,Germany,Norway,Switzerland,Italy,Belgium,United Kingdom,Spain,Austria
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 4812098.06
EU funding (EUR): 3972294.36
Participants: 28
Project status: SIGNED

STOP SPREAD BAD BUGS is a new multi-disciplinary research/training consortium built to combat the alarming problem of global antimicrobial resistance. Multi-drug resistance (MDR) in bacteria is becoming increasingly common thus urgently calling for alternative approaches to develop and implement novel antibiotics. We envision a definitive solution that will require a paradigm shift. Its foundation shall be the training of a new generation of future 15 Early Stage Researchers (ESRs) by world-renowned experts in the field of drug development, infectiology, immunology and pharmacology. A unique state-of the-art teaching/training pipeline shall be developed across 7 academic and 5 SME partners with complementary expertise in the development and testing of novel approaches to antimicrobial therapy in humans. We shall establish knowledge and expertise on carbohydrate and protein chemistry for the discovery of new drug candidates, while characterizing the underlying mechanism of existing compounds for treatment of microbial infections. Computational modelling shall optimize the interactions of the novel entities with selected pathogens. A range of infection models allows partners to simultaneously determine compound efficacy in pre-clinical settings and investigate the potential effects of the novel antimicrobials on host tissues. State-of-the-art imaging tools will be applied to track the bacteria and novel compounds in these test systems. Uniquely, the pipeline will also determine the pharmacokinetics, and the effects of compounds on host microbiota and host immunity. Understanding the mechanisms of action of the novel antimicrobials shall provide insights into new antimicrobial mechanisms, which may be further exploited in spin-off projects. This approach means that the STOP SPREAD BAD BUGS consortium will deliver uniquely trained, multi- and interdisciplinary ESRs that will take the continuing fight against global MDR safely into the future.

Keywords: antimicrobial resistance novel antibiotic solutions antimicrobial peptides non digestible oligosaccharides computational modelling pharmacokinetics mucosal immunology microbiota
Virtual reality emotion training tool (E-Virt)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-11-01
End date: 2025-06-30
Duration (months): 20.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The ERC starting grant project CoPAN (804582) is an innovative, interdisciplinary cross-boundary project. In the project, we study the function, underlying neurophysiological mechanisms, development and evolution of emotional expressions, which has shown us that emotions play a pivotal role in daily life in humans and great apes alike. We also show that emotional expressions in real life are more complex than the acted expressions used in emotion research or applications. I here propose to build on the fundamental knowledge and develop a virtual reality training tool targeting the broader public and clinical populations.
Arctic Pollution in a One Health perspective - from complex challenges to sustainable solutions (ArcSolution-Hop On)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Norway,Faroe Islands
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 42.0
Total project cost (EUR): 599997.5
EU funding (EUR): 599997.5
Participants: 2
Project status: CLOSED

The Arctic is undergoing rapid environmental changes due to climate change and pollution, significantly affecting human health and society. The Faroe Islands and Greenland, both hunter societies, are particularly impacted. To address these challenges, the hop-on partner will bring over 40 years of research experience on marine pollutants' health effects. The hop-on partner’s contribution will enhance the ArcSolution project, by focusing on human exposure and the cultural implications of environmental contaminants. The new WP7 will re-examine a birth cohort at age 40 to assess long-term health outcomes, as well as incorporating a gender perspective through a cross-sectional study of mercury levels in the broader Faroese population. Collaboration with the Faroese Whalers’ Association and East Greenland hunters will enable us to assess PFAS exposure's impact on immune response in these two groups. WP7's community-based approach, involving local stakeholders and citizen science projects, aims to strengthen community resilience and develop sustainable strategies for reducing pollutant exposure. The project's findings will inform public health and environmental management strategies, contributing to the preservation of traditional lifestyles while at the same time informing about health risks. The hop-on partner's involvement will strengthen the ArcSolution project, and generate actionable knowledge and influence policies, benefiting Arctic communities.

Keywords: marine,coastal and ocean pollution
Functionalized Graphene Based Electrode Material for Lithium Sulfur Batteries (FunGraB)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Czechia
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-04-01
End date: 2023-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

FunGraB project addresses the pressing need for ecofriendly, sustainable, and rechargeable batteries with high capacity, energy density, and long lifespan, which will significantly expand the energy storage market. With the rapid development and broad application of mobile devices, electric and unmanned vehicles, as well as with the rise of smart grids and networks for “the internet of things”, the demand for batteries with higher performance, lower cost, and lower environmental burden is rapidly growing. In order to address the aforementioned challenges, various strategies emerged over the past few years for the development of advanced composite cathodes designed for high sulfur utilization and stability. In particular, the pinning of sulfur is pursued by engineering materials as high-affinity hosts for sulfur to hinder the shuttling of lithium polysulfides. FunGraB project aims to deliver the upscaling of an industrially-relevant one-step novel manufacturing process for a lithium-sulfur batteries electrode material, enabling a significant boost in the cycling stability, without sacrificing its performance (i.e., capacity). This will be achieved through the implementation of cost-effective materials and processes along with taking our Technology Readiness Level from 2 to 4, thus shaping a significant business opportunity (enabling us to continue development within an EIC Transition project).
Personalized Genetic Risk Profile: A New Tool to Guide Prevention of Serious Mental Illness (PersonalRiskProfile)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499891.25
EU funding (EUR): 1499891.0
Participants: 1
Project status: SIGNED

Serious mental illness (SMI) has devastating effects. The key clinical challenge is to identify individuals at increased risk for SMI for personalized prevention. However, the specialized clinical teams aiming to identify at-risk individuals face major challenges: risk assessment is suboptimal as only clinical characteristics are considered, and only psychosis is considered ignoring risk for SMI disorders without psychosis. Genetics has great potential to significantly improve identification of at-risk individuals. However, the major current problem preventing clinical implementation is that no appropriate method exists to accurately assess genetic risk of multiple SMI disorders. In this ambitious PersonalRiskProfile-project, my team and I will develop this much-needed method and software: the personalized genetic risk profile (PGRP)-method. PGRP will use advanced genetic techniques to simultaneously compute the risk for multiple SMI disorders that regularly but not always include psychosis: schizophrenia, bipolar disorder and major depressive disorder. Specifically, we aim to Optimize Prediction & Generalize to Diverse Ancestries (Aim 1), by including polygenic risk scores for SMI-disorders and auxiliary helper-traits, including rare genetic variants, and accounting for time-since-risk-assessment effects and family information; and to Validate & Prepare for Implementation (Aim 2), by validating PGRP in clinical cohorts, determining the best strategy to integrate PGRP with clinical risk assessment, investigating the stakeholders’ perspective, and developing an Online Dashboard to intuitively present PGRP-results. This ambitious interdisciplinary project provides a key step towards personalized prevention using genetics. I am uniquely qualified to lead, having established myself as international expert in statistical genetics through development of high-impact innovative methods and prestigious fellowships, combined with my clinical expertise as psychiatrist.
DIGITAL PASSPORT SOLUTIONS FOR DYMAN TECHNOLOGIES & HPCS (DPP4DYMAN)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Spain,Türkiye
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 27.0
Total project cost (EUR): 391875.0
EU funding (EUR): 391875.0
Participants: 2
Project status: CLOSED

DYMAN (GA: 101161930) is an ongoing EIC-Pathfinder project aiming to develop a new adsorption chiller design with new low-T absorbents and adsorption heat exchangers, that are dynamically managed in data centres. It started in July 2024 and will continue for 36 months. The current DYMAN consortium consists of 10 entities (6 SMEs, 1 public university, 1 RTO and 2 non-profit organisations), from 4 different EU countries. Ekodenge (EKO) from Türkiye, who has successfully collaborated with some partners in the consortium and who develops SW services aiming to enhance the novel solutions of DYMAN, has proposed to collaborate with the consortium, which has been shared with the scope of actions and EKO’s possible involvement has been approved by the consortium in September 2024. DYMAN is developing new cooling generating technologies, materials to improve the cooling efficiency of data centres. With this hop-on proposal, EKO will develop digital tools for the enhancement of management & monitoring of cooling systems while addressing the unique requirements of cooling technologies and data centres: 1) dynamic Digital Product Passports (DPPs) for cooling technology developers that enables EU market compliance, life cycle traceability, and exchange of product information. 2) digital twin and DPP-linked Digital Building Logbooks (DBLs) for data centres which is a centralized repository for data on energy performance, sustainability metrics, used materials and components. This proof-of-concept application will contribute to EKO’s international visibility in competitive sustainability/ circular economy markets and will enable Türkiye to advance in the EU R&I environment. In addition to 5 existing specific objectives of DYMAN project, this Hop-On project addresses: - A new specific objective (SO): Development of interoperable, dynamic digital tools (DPPs and DBLs) for enhanced management / tracking of DYMAN cooling technologies and HPCs - 2 sub-objective supporting existing SO

Keywords: digital building logbook dbl,digital product passport dpp
Investigting the effects of psychedelics on Lateral Habenula-Dorsal Raphe Nuclei circuitry in a Chronic Unpredictable Stress model of depression (PsyHab)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 236340.0
EU funding (EUR): 236340.0
Participants: 1
Project status: SIGNED

The lateral habenula (LHb) and dorsal raphe nuclei (DRN) are key structures in the brain involved in mood regulation, reward processing, and aversive signaling. The LHb is a small, yet critical brain region that acts as a major negative regulator of midbrain dopamine systems. It plays a significant role in processing aversive stimuli and encoding negative reward prediction errors, which are crucial for adaptive behaviors and decision-making processes. The DRN, on the other hand, is the primary source of serotonergic projections to various brain regions and is a key structure involved in mood regulation and the pathophysiology of depression. Understanding the precise anatomical and functional connections between the LHb and DRN is essential, as disruptions in the LHb-DRN circuitry are believed to contribute to various neuropsychiatric disorders, including depression and anxiety. Psychedelics have garnered significant interest in both clinical and neuropharmacological research due to their profound effects on perception, cognition, and mood. Their influence on the activity of the LHb is not yet fully understood, but we hypothesize that it could potentially reduce the hyperactivity of the LHb by altering its neural inputs or by modulating the overall excitability of the neurons within the LHb. The proposed research is aimed at examining how psychedelics affect LHb-DRN circuitry in the chronic mild stress model of depression. We will combine viral tracing, in situ sequencing, fiber photometry, chemogenetics, and unsupervised learning in order to evaluate the effects that psychedelics exert on projections from DRN to LHb, and how those translate into changes in animal behavior. The proposed research will contribute to a better understanding of the antidepressant potential of psychedelics and help to improve pharmacotherapy of affective disorders. The applicant will acquire new skills, and the experience to launch and lead his own research group in the future.

Keywords: lateral habenula,dorsal raphe nuclei,psychedelics,animal models of depression,in situ sequencing,fiber photometry,dreadds,unsupervised learning,psilocybin,doi
Magnetic memory supraparticles for perceptual matter (SmartRust)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 1999250.0
EU funding (EUR): 1999250.0
Participants: 1
Project status: SIGNED

So far, materials are seen as passive items. This project aims at providing a solution that can turn objects into matter that can perceive and communicate trigger events. If materials are turned capable of reporting their encountered history, this will significantly contribute to i) ensuring product safety and reliability, ii) making predictive maintenance possible, iii) making complex recycling fates of materials transparent, and iv) enabling autonomous, robot-controlled, resilient manufacturing (Industry 4.0). The key to realize this vision is to make use of smart magnetic particles, largely based on iron oxide (SmartRust). To achieve SmartRust, micron-sized (1-10 µm) supraparticles are composed of magnetic nano building blocks, the “signal transducers”, which are combined with other non-magnetic moieties, the “sensitizers”. A toolbox-like approach using spray-drying allows for nanoparticle assembly of a transducer and a sensitizer type of choice to specifically target a desired type of stimulus. The SmartRust particles are then integrated in materials` matrices. It is hypothesized – and yet an open research question! - that there is an interplay of two magnetic interaction principles: on a hierarchical level I, a trigger event will alter the intra-supraparticle magnetic interactions of the nanoparticles within individual supraparticles. On a hierarchical level II, a trigger event will alter the inter-supraparticle magnetic interactions among the supraparticles when the matrix of the materials, where the supraparticles are embedded in, is altered. The scientific idea is that this magnetic interaction information can be read out fast, easily, in a non-destructive way and from within a material, enabled by the technique magnetic particle spectroscopy (MPS). If this endeavour is successful in obtaining a meaningful signal-structure-trigger correlation, ultimately, design rules could be deduced how to create conscious matter using SmartRust.

Keywords: supraparticles nanoparticle assemblies magnetic nanomaterials perceptual matter magnetic interaction recorders signal transducers sustainable use of materials smart materials interactive materials 3d printing environmental influences