Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecular mechanisms of arenavirus cell entry and antibody-mediated neutralization (ARENAVIRUS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Over the last decades, multiple arenaviruses have emerged as zoonotic human pathogens. They cross the species barrier from their natural rodent hosts to humans and cause severe human disease. A key determinant of viral zoonotic transmission is the ability to bind the receptor molecules displayed on the surface of the host cell. Despite the threat these viruses cause to public health, little is known of how they infect the host and how they are targeted by the immune response. Furthermore, the treatment and prevention options are currently extremely limited. Using techniques in structural biology, virology, immunology and cell biology, the proposed work aims at demonstrating the molecular mechanisms by which arenaviruses attach to human cells and are neutralized by the humoral immune response. First, crystallographic analysis of viral attachment glycoproteins alone and in complex with functional cellular receptors will be performed. Second, recombinantly derived viral glycoproteins will be used as immunogens for generation of specific monoclonal antibody libraries. The co-crystal structures of viral glycoproteins with cross-reactive, neutralizing antibodies, carefully selected using cell-based assays, will reveal the structural basis of antibody-mediated arenavirus neutralization. Therefore, by analogy to the development of antibody-based therapy against Ebola virus, the outlined multidisciplinary investigation will enable the rational design of antiviral reagents and vaccines. The cross-disciplinary expertise, training and infrastructure available in the host and partner organizations will allow the Researcher to establish herself as a highly-skilled expert in molecular and structural virology. As an independent, multifaceted scientist, she will be able to make a tangible contribution to the development of novel antiviral therapies, thus improving the public health and economy and adding to science base both in Europe and worldwide.

Keywords: arenaviruses,emerging zoonotic viruses,viral hemorrhagic fevers,virus host cell interaction,molecular basis of antibody mediated virus neutralization
Insulation monitoring for IT Aerospace Electrical Systems (IMITAES)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,United Kingdom,United Kingdom
Call: Insulation Monitoring for IT Grounded (Isolation Terra) Aerospace Electrical Systems (H2020-CS2-CFP11-2020-01, 2020)
Start date: 2021-07-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 848257.5
EU funding (EUR): 699999.88
Participants: 3
Project status: SIGNED

The project will develop, validate and demonstrate a roadmap for a monitoring system suitable for insulation monitoring of IT grounded aerospace electrical systems. As aerospace electrical systems move towards higher voltages, it is essential to guarantee reliability of operation and safety for users. IT isolation in electrical distribution systems provides many benefits in terms of safety for high reliability applications. In IT systems the use of insulation monitoring devices is mandatory. However, no insulation monitoring device suitable for aerospace specifications currently exists. The project will demonstrate the first insulation monitoring system for IT electrical installation based on the requirements of the aerospace market. The project, led by the University of Sheffield and Bender, joins two leading academic and industrial partners with significant research and development expertise in the field of insulation and monitoring equipment for electrical power systems.

Keywords: insulation,condition monitoring,electrical systems
Pyrazine Signalling in Commensal and Pathogenic Bacteria (PyraSig)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Germany,Germany
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-06-30
Duration (months): 66.0
Total project cost (EUR): 1499250.0
EU funding (EUR): 1330157.91
Participants: 2
Project status: SIGNED

Quorum sensing (QS) is a bacterial cell–cell communication process involving the production, release, and detection of extracellular signal molecules called autoinducers. QS is key to all microbiology as it enables otherwise solitary bacteria to coordinate complex cooperative tasks such as biofilm formation and pathogenesis. Consequently, targeting QS is a promising new concept for antimicrobial therapy. However, for this concept to become reality, we must first identify QS systems in pathogenic bacteria, discover the relevant autoinducers and study the underlying regulatory principles. I recently identified a new QS pathway in Vibrio cholerae, the causative agent of cholera disease. The autoinducer of the system is DPO (3,5-dimethylpyrazin-2-ol), a new molecule to biology and the first pyrazine involved in QS. DPO production is widespread among microbes including pathogenic and commensal bacteria. V. cholerae synthesizes DPO from host mucins and our preliminary data show that DPO controls collective phenotypes, such as biofilm formation and toxin production in this major human pathogen. I therefore hypothesize that DPO connects virulence, QS and communication with the host microbiota in V. cholerae and related bacteria. The overarching goal of this project is to understand the roles of DPO in host-microbe interaction and collective behaviours. To this end, we will pursue three key research goals. First, we will study the molecular parameters underlying DPO-signalling and probe the global effects of DPO on gene expression. Second, we will focus on the role of DPO in virulence of V. cholerae and other pathogens. Third, we will probe the effect of DPO on microbial behaviours, such as swarming and biofilm formation. This combined work will provide a comprehensive model for DPO-signalling in bacteria, which will not only advance the fundamental understanding of QS-based communication strategies, but might also provide the framework for QS-inspired anti-infectives.

Keywords: quorum sensing,regulatory rnas,biofilms
Grid for Vehicles - Analysis of the impact and possibilities of a mass introduction of electric and plug-in hybrid vehicles on the electricity networks in Europe (G4V)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Smart energy networks
Action type: Collaborative project
Countries involved: Germany,Sweden,Netherlands,Portugal,France,United Kingdom,Germany,Germany,Spain,Sweden,Spain,Netherlands,Italy
Call:  (FP7-ENERGY-2009-1, 2009)
Start date: 2010-01-01
End date: 2011-06-30
Duration (months): 18.0
Total project cost (EUR): 3759214.2
EU funding (EUR): 2531257.75
Participants: 14
Project status: CLOSED

Electric and plug-in hybrid vehicles (EV, PHEV) have the potential to contribute significantly to solving contemporary and future environmental and economic challenges of mobility. Various projects in different EU member states are currently addressing the subject in an isolated manner. The G4V consortium consisting of major European electric utilities and distinguished academic institutions are now adopting a holistic European approach to analyse the impact of a mass introduction in detail in order to optimise the grid infrastructure and make use of the inherent opportunities this represents for the operation of smart grids and energy efficiency. The objective of the project is to develop an analytical framework for the planning of technological developments in the grid infrastructure and the definition of related ICT and policy requirements in order to cope with the mass introduction of EV and PHEV. On the one hand, the aim is to clearly understand the effects of a mass introduction under physically given parameters and taking into account local aspects in different EU member states. On the other hand, the opportunities consisting in active demand and storage possibilities will be extensively explored as these also imply options for managing the possible negative impacts on the grid. The project will deliver recommendations on aspects such as possible ICT solutions, grid services anticipating, RES integration, prediction of mobile customers who are potential energy traders and the impact of dedicated tariffs. To ensure an open and holistic approach, the project will take all stakeholders into account and has established an advisory board consisting of institutions along the whole value chain. The project will generate fast and openly available results within 18 months: An analytical framework to evaluate the impact of a large scale introduction on the grid infrastructure and a visionary “road map” for the year 2020 and beyond.

Keywords: electric vehicles plug-in hybrid vehicles grid infrastructure smart grids balancing power standardisation
Development of postcombustion CO2 capture with CaO in a large testing facility: “CaOling” (CAOLING)

Framework: FP7 — Cooperation
Programme: Energy
Destination: CO2 capture and storage technologies for zero emission power generation
Action type: Collaborative project
Countries involved: Spain,Spain,Finland,United Kingdom,Spain,Germany,Canada
Call:  (FP7-ENERGY-2009-1, 2009)
Start date: 2009-12-01
End date: 2013-05-31
Duration (months): 42.0
Total project cost (EUR): 6601095.72
EU funding (EUR): 3733542.0
Participants: 8
Project status: CLOSED

This project is aiming at the scaling-up of one of the most promising concepts for CO2 capture from coal power plants: postcombustion carbonate looping systems. This project focuses on the experimental pilot testing and scaling up of the process at scales in the 1 MW range. The 1 Mw carbonate looping pilot will be built in the Hunosa 50 Mwe CFB coal power plant of “La Pereda”, using a side stream of flue gases of the commercial plant. A parallel research program will be developed along the activities to design, build and test at the pilot, including research activities at lab-scale and fundamental knowledge on sorbent properties. This program will be developed by the scientific leaders in the development of this technology worldwide, and will help with the design of the pilot to a better understand of the results. The scope of this project is the necessary step towards a possible pre-industrial demo plant (10s of Mw scale) .This is clearly in line with the expected level of development for this technology outlined in the European Technology Platform for Zero Emission Fossil Fuel Power Plants and also with wider targets to accelerate the development of breaktrough technologies for CO2 capture under the EU Strategic Enegy Technology Plan.

Keywords: innovative co2 capture
Geothermal Engineering Integrating Mitigation of Induced Seismicity in Reservoirs (GEISER)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable electricity generation
Action type: Collaborative project
Countries involved: Germany,France,Iceland,Netherlands,Switzerland,Norway,France,Netherlands,Italy,Italy
Call:  (FP7-ENERGY-2009-1, 2009)
Start date: 2010-01-01
End date: 2013-06-30
Duration (months): 42.0
Total project cost (EUR): 7115977.46
EU funding (EUR): 5308869.0
Participants: 13
Project status: CLOSED

The project contributes to the improvement of the concept of Enhanced Geothermal Systems by investigating the role of induced seismicity, which is twofold: (i) an instrument to image fluid pathways induced by hydraulic stimulation treatments, which has been done to some extent in previous projects; and (ii) an implication of such treatments to potential seismic hazards. The mitigation of induced seismicity to an acceptable level is the major intent of this project. For this purpose, we set as our goals (1) to understand why seismicity is induced in some cases but not in others; (2) to determine the potential hazards depending on geological setting and geographical location; (3) to work out licensing and monitoring guidelines for local authorities, which should include a definition of what level of ground motion is acceptable; and (4) to develop strategies to fulfil the task of the stimulation and improve the hydraulic properties of the geothermal reservoir without producing large magnitude events. To accomplish the project goals a high quality database of case studies will be assembled. This will include data on seismicity and ground motion, geomechanics, reservoir characteristics, injection/production, and surface deformation, as well as information on the local stress field and local geology. The interpretation will be based on data from the sites: Soultz-sous-forêts (France), Basel (Switzerland), Groß Schönebeck (Germany), KTB (Germany), Larderello/Latera (Italy), Campi Flegrei (Italy), Hengill, Krafla, Reykjanes (Iceland), Groningen (Netherlands), and others (Berlin, El Salvador; The Geysers, USA). The GEISER-project will overcome shortcomings of previous work by including model based forecast of stimulation and/or production induced seismicity. Developing soft stimulation strategies and guidelines on how to react on induced seismicity will support the acceptance of geothermal applications.

Keywords: geothermal energy,enhanced geothermal systems,induced seismicity,soft stimulation strategies
Biowaste and Algae Knowledge for the Production of 2nd Generation Biofuels (BIOWALK4BIOFUELS)

Framework: FP7 — Cooperation
Programme: Energy
Destination: Renewable fuel production
Action type: Collaborative project
Countries involved: Italy,Denmark,Denmark,India,Jordan,Latvia,Spain,Sweden
Call:  (FP7-ENERGY-2009-1, 2009)
Start date: 2010-04-01
End date: 2015-03-31
Duration (months): 60.0
Total project cost (EUR): 4077440.52
EU funding (EUR): 2902000.2
Participants: 12
Project status: CLOSED

The Biowalk4Biofuels Project aims to develop an alternative and innovative system for biowaste energy recovery and use of GHG emissions to produce biofuels, using macroalgae as a catalyser, in a multidisciplinary approach. The objectives of the project are: production of a cost-efficient biogas without using cereal crops; optimise the production of biogas per amount of biowaste and CO2 used, with low land use for plant facilities; and increase and optimize the types of biowastes that can be utilised for biogas production. To achieve the underlined objectives, research activities are to be carried out on the selection of adequate macroalgae species that can reach high output biomass yields and high carbohydrate content. Pre-cultivation of protoplasts will allow to obtain easily available biomass for feeding the cultivation open floating ponds within shorter periods, thanks to the rapid proliferation of germplasm, diminishing the life-cycle of macroalgae. In addition, the relationship between growth and energy potential of selected species with the amounts/characteristic of GHG emissions and biowaste introduced in the cultivation medium is to be studied. . After fermenting the algal biomass and other biowastes, the cycle is closed by producing biogas to be used for electricity and heat generation and as a transport fuel. A high quality biogas is expected, hence a purification step will proceed the final product. Furthermore, organic residues output from the methanation biodigestor are to be used as fertilizer after solid/liquid separation. The liquid fraction of the digestate will be treated in a biological oxidation system .A portion of the unseparated outlet effluent from the oxidation system (solids + liquid) will be fed to the macroalgae cultivation (instead of the enrichment with chemical N-P-K fertilizers). Meanwhile, the other portion will be reused as feeding for the AD plant section. This process solution will permit to feed with several critical biowastes the biodigester, transforming them into a resource. The expected impact is to produce a cost-efficient, low energy-intensive, purified biogas, to reduce negative environmental impacts from industry (GHG emissions) and biowaste. The multidisciplinary approach solution to reduce GHG emission and process biowaste, while producing energy, seeking for the future replications in other locations.

Keywords: biowaste,macroalgae,biogas
Innovative CO2 capture (ICAP)

Framework: FP7 — Cooperation
Programme: Energy
Destination: CO2 capture and storage technologies for zero emission power generation
Action type: Collaborative project
Countries involved: Norway,France,Netherlands,Denmark,Germany,Denmark,Germany,France,China,Australia,Sweden,Denmark,Netherlands
Call:  (FP7-ENERGY-2009-1, 2009)
Start date: 2010-01-01
End date: 2013-12-31
Duration (months): 48.0
Total project cost (EUR): 6059305.0
EU funding (EUR): 4325202.0
Participants: 14
Project status: CLOSED

In post-combustion CO2 capture, a main bottleneck causing significant reduction in power plant efficiency and preventing cost effectiveness is the low flue gas CO2 partial pressure, limiting membrane flux, solvent selection and capacity. In pre-combustion CO2 capture, key bottlenecks are number of processing steps, possible low hydrogen pressure, and high hydrogen fraction in the fuel Global deployment of CO2 capture is restrained by a general need for prior removal of SO2. iCap seeks to remove these barriers by developing new technologies with potential for reducing the current energy penalty to 4-5% points in power plant efficiency, to combine SO2 and CO2 removal, and to reduce the avoidance cost to 15 €/tonne CO2. iCap will: Develop solvents forming CO2 hydrates or two liquid phases enabling drastically increased liquid phase CO2 capacity, radically decreasing solvent circulation rates, introducing a new regime in desorption energy requirement, and allowing CO2 desorption at elevated pressures; Develop combined SO2 and CO2 capture systems increasing dramatically the potential for large scale deployment of CCS in BRIC countries and for retrofit in Europe. Develop high permeability/ high selectivity low temperature polymer membranes, by designing ultra thin composite membranes from a polymeric matrix containing ceramic nano particles. Develop mixed proton-electron conducting dense ceramic-based H2 membranes offering the combined advantages of theoretically infinite selectivity, high mechanical strength and good stability. Develop and evaluate novel coal and gas-based power cycles that allows post-combustion CO2 captures at elevated pressures, thus reducing the separation costs radically. Integrate the improved separation technologies in brownfield and greenfield power plants, and in novel power cycles in order to meet the performance and cost targets of the project

Keywords: co2 capture,post-combustion,phase-change solvents,combined so2 and co2 removal,pre-combustion,membranes,novel power cycles
The effects of antibiotic administration on the emergence and persistence of antibiotic-resistant bacteria in humans and on the composition of the indigenous microbiotas at various body sites (ANTIRESDEV)

Framework: FP7 — Cooperation
Programme: Health
Destination: Translating research for human health
Action type: Collaborative project
Countries involved: United Kingdom,Sweden,Italy,Switzerland,Germany,Netherlands,Netherlands,Germany,United Kingdom
Call:  (FP7-HEALTH-2009-single-stage, 2009)
Start date: 2009-11-01
End date: 2013-04-30
Duration (months): 42.0
Total project cost (EUR): 7080080.31
EU funding (EUR): 5368088.0
Participants: 11
Project status: CLOSED

The objective of the HEALTH-2009-2.3.1-2 call is to study the impact of different antibiotics on the prevalence of resistant bacteria in the human host. In ANTIRESDEV we will achieve this objective using the approaches suggested in the call as follows. We will use culture-based and culture-independent approaches to investigate the impact of four different types of antibiotics (with different modes of action, antimicrobial spectra and pharmacokinetic properties) on the emergence of antibiotic-resistant organisms and their persistence at several body sites. Disruption of the indigenous microbiota is recognized as an important factor in the persistence and transmission of antibiotic-resistant organisms, therefore we will also study the ecological impact of the antibiotics on the indigenous microbiotas of several body sites using culture-dependent and -independent techniques. We will then identify, using state-of-the-art microarrays, the genes responsible for resistance in the antibiotic-resistant organisms isolated. The genetic elements involved in resistance transfer by a number of these organisms will also be determined as knowledge of these elements is essential to fully understand the mechanisms underlying resistance transmission. By using state-of-the-art 454 pyrosequencing we will determine the full complement of resistance genes (the “resistome”) present in cultivable and not-yet-cultivated members of the oral and faecal microbiotas and the effect on these resistomes of antibiotic administration. Another important aspect of the dynamics and transmission of resistance is the fitness cost associated with resistance acquisition by an organism and we will investigate this in a variety of clinically-important organisms. We will ensure that the results of this study are made available to appropriate governmental and healthcare agencies so that they can be used to help in the formulation of measures designed to reduce the spread of antibiotic resistance.

Keywords: antibiotic resistance genetic determinants microarrays ecology fitness cost resistome pyrosequencing