Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Commercialisation of Advanced Composite Material Technology: Carbon-Glass Hybrid in PowderEpoxy for Large (60-100m) Wind Turbine Blades (POWDERBLADE)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Ireland,Netherlands,United Kingdom
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2016-1, 2016)
Start date: 2016-11-01
End date: 2019-12-31
Duration (months): 38.0
Total project cost (EUR): 3558500.0
EU funding (EUR): 2731700.0
Participants: 4
Project status: CLOSED

POWDERBLADE aims to gain market acceptance and rapid market take up of an innovative materials technology involving carbon/glass fibres in powder epoxy to be commercialised initially in the production of larger wind turbine blades (60 metre +). The immediate impact of this disruptive materials technology in the wind energy sector will be reduced wind turbine cost (-20%). This in turn will lead to increased productivity of low-carbon energy from more rapid market deployment of large turbines. The reduction in costs and increase in productivity will reduce the Levelised Cost of Electricity (LCOE) for the European citizen – the ultimate beneficiary of this innovation. This ambitious project is led by Éire Composites, an established industry player in composites manufacturing for the Aerospace and Renewable sectors and an experienced FP7/Horizon 2020 participant.In the year after project end, ÉireComposites will generate over €7m in revenue from direct sales of larger blade components using the new materials, increasing to €39m by 2021. The longer term commercial strategy is to focus on recurring revenues from the supply of advanced materials directly to manufacturers to produce blades and other products under license. This revenue stream will generate €60m by 2021. ÉireComposites will employ an additional 78 staff in direct production at project end increasing to 489 employees over both revenue streams three years later. Suzlon, a large wind OEM and end user, is the second industry partner. Their involvement demonstrates early market acceptance of the new technology. Suzlon are committed to investing substantial funds in the commercialisation of this technology in return for the opportunity to gain significantly as the first large industry player to market with light, cost-effective carbon-glass hybrid blades. Technology partner (University of Edinburgh) and innovation specialists (WestBIC) will support the industry partners in achieving the goals of POWDERBLADE.

Keywords: secure clean efficient energy,wind energy,offshore turbines,composites,large wind blades
Unravelling Multi-scale Oral Lubrication Mechanisms (macro-to-nano): A Novel Strategy to Target Satiety (LubSat)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2017-11-01
End date: 2023-10-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Obesity is a serious form of malnutrition that is known to have substantial morbidity and mortality consequences. Hence, to directly promote weight management, there is an immense need to design satiety-enhancing foods that terminate appetite for longer periods after consumption. Although the concept of “satiety cascade” was proposed nearly 20 years ago, the changing dynamics of food properties in the oral mucosa remains the greatest source of uncertainty in food design. In particular, our quantitative multi-scale understanding of lubrication of the human salivary film when exposed to stimuli from food biomolecules, which in turn can have significant appetite suppression consequences, remains poorly understood. The key limitation to accurately measure oral lubrication is the lack of tribo-contact surfaces that effectively emulate the oral surfaces (i.e. the soft, slippery mucous-coated human tongue and the upper palate). I intend to address these deficiencies by proposing a whole hierarchy of scales (from human scale down to nanometres). To do so, I will use a unique combination of in vitro and in vivo experimental approaches to quantitatively establish molecular mechanisms of salivary lubrication and its psychological and physiological consequences. In order to determine the true oral lubrication mechanism of food-saliva mixtures, I propose to develop and deploy new instrument based on novel 3D printing coupled with both surface-patterning and unique biochemical functionalization to emulate the surface topologies and chemistries of oral environments at macro-to-nano scales. The ground-breaking nature of the project will be to discover how food-mediated alteration of salivary lubricity will result in enhanced satiety perception for longer periods. This will bring the paradigm shift in thinking that is needed to underpin the creation of the next generation of weight management foods and allow the development of coordinated public health strategies to tackle obesity.

Keywords: oral processing,satiety,tribology,lubrication,food colloids,biopolymer gels,mucins,sensory,saliva
High Precision Process Chains for the Mass Production of Functional Structured Surfaces (ProSurf)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Technologies for Factories of the Future
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Germany,Belgium,China,Netherlands,Denmark,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal
Call: New product functionalities through advanced surface manufacturing processes for mass production (H2020-FOF-2017, 2017)
Start date: 2018-01-01
End date: 2021-06-30
Duration (months): 42.0
Total project cost (EUR): 5213365.0
EU funding (EUR): 4995727.0
Participants: 17
Project status: CLOSED

The ProSurf project aims to enhance the surface functionalities of six demonstrator parts by using a wide range of high precision manufacturing technologies, such as diamond machining techniques, enabling the mass production of cost effective, structured parts with accurate replication technolo-gies, like micro injection moulding. By implementing these technologies to manufacture a variety of benefiting functionalities, it is critical to assess the parts quality in a safe and fast manner. Therefore, the ProSurf project incorporates the development of robust in-process metrology as well as the derivation of the surfaces’ functions to three dimensional parameters for a fast measurement of functional relevant surface characteristics and specific function testing of the produced demonstrators. Due to the spectrum of surface functionalities linked to the part demonstrators and their varied application fields that range from optical to medical, ProSurf makes possible to reach a high impact on several areas of the society by, e.g. increasing the safety of medical procedures and the performance of moulds for ceramic injection moulding as well as cleaning rolls for electronic parts.

Keywords: functional surface structures,precision machining,mass production,process chain
In Blockchain We Trust(Less): The Future of Distributed Governance (BlockchainGov)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Italy,France
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1997000.0
EU funding (EUR): 1436999.3
Participants: 2
Project status: SIGNED

The general malaise of liberal democracies—characterized by a gradual erosion of trust in traditional institutions (such as banks) and new intermediaries (e.g. social media)—has spurred the development of new blockchain-based applications (like Bitcoin) that allegedly obviate the need for trust. Often described as a “trustless” technology, blockchain’s potential for disintermediation has been touted as a catalyst of innovation that could displace existing power structures. But is it shifting power away from former centers of power only to create new ones, or can it lead to an actual new organisation of power? BlockchainGov is an interdisciplinary project that will study the impact of blockchain technology on new and existing governance structures, and its consequences for legitimacy and trust. First, it will investigate the governance of existing blockchain systems, and analyse the power dynamics at play within these systems. Second, it will examine the legitimacy and long-term sustainability of existing attempts at distributed governance, through the lenses of legal and political theory. Third, it will explore the potential of blockchain technology to support new models of distributed governance providing an architecture for decentralized and participatory decision-making with attributes of transparency and accountability. Last, it will experiment with these new models at different levels of governance, from the community level to the global governance level. The project will open a new field of scholarship on “distributed governance” that uniquely combines the disciplines of computer science, political science and law. It will provide key empirical and theoretical contributions to science, with important policy implications to the broader questions of global governance. Bringing this project to life requires a funding scheme compatible with a high-risk/high-gain vision to finance a fully dedicated and highly motivated research team with multidisciplinary skills.

Keywords: blockchain technology,internet governance,commons governance,legal theory
c-GMP compliance of C-stem, an IPSc based cell therapies production technology (C-stemGMP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2019)
Start date: 2019-11-01
End date: 2021-10-31
Duration (months): 24.0
Total project cost (EUR): 3382855.0
EU funding (EUR): 2367998.0
Participants: 1
Project status: CLOSED

Scaling-up cell therapy manufacturing provides many benefits: the capacity to replace failing tissues in patients suffering from incurable chronic or degenerative diseases, affordable treatments and the economic viability of the development of cell therapies for rare diseases. The baseline of TreeFrog Therapeutics (TFT), “Cell Therapy for All”, encapsulates this vision.TFT has already obtained outstanding results with its C-StemTM stem cell culture technology, fully scalable and allowing a high cell multiplication factor. The cell therapy market has boomed since 2012. In 2018, 1,028 clinical trials were underway according to the Alliance for Regenerative Medicine and big pharmas invested €6.2bn in cell therapy programs. The FDA anticipates to approve « 10 to 20 cell and gene therapy products a year » by 2025. A critical bottleneck remains for the cell therapies that will reach the market within 5 to 10 years: the industrial production of human induced pluripotent stem cells, the raw material for cell therapies. Current manufacturing models do not meet the standards of regulatory authorities and healthcare systems in terms of safety, cost, volume and lead time. With C-StemTM, TFT is in the best position to become the global supplier of stem cells for cell therapy’s industry. Tailored for cost-killing mass-production of stem cells, while defining a new quality standard for cellular products, C-StemTM needs to be certified for “Good Manufacturing Practices” (GMP) to be used in clinical settings and capture its market. This project requires, within 24 months, to develop a GMP encapsulation device, to replace non-compliant materials, while developing relations with EU/US regulatory agencies and clients from the pharmaceutical industry. TFT has a “go-global” strategy and aims at leading its market within 7 years. Funding from the H2020 Instrument PME Phase 2 would secure the project and consolidate TFT on the financial level, a key element to outpace non-european players.

Keywords: encapsulation,cell therapy,micro fluidics
Genomes, food and microorganisms in the (pre)history of cat-human interactions (FELIX)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Italy
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 1999420.0
EU funding (EUR): 1999420.0
Participants: 1
Project status: SIGNED

Pest-control agent, object and symbol of value in past civilisations, companion animal, and iconic celebrity of the web in the modern society, the domestic cat has an intricate bond with humans. This relationship started more than 10,000 years ago, when cats began scavenging and hunting pests that infested granaries of early farming communities in the Near East. Later in history, cats from Egypt dispersed in the Mediterranean following routes of human trade and connectivity. Cats established a unique and intimate bond with humans, and this, together with their adaptability, determined their global dispersal. Yet, the biological and cultural trajectories behind the development of cat-human interactions, and the implications of the global dispersal and evolutionary success of the domestic cat remain enigmatic. By generating a complementary set of unique and as yet unexplored multidisciplinary data, from paleogenetics, to organic chemistry and microscopy, FELIX will dig deeply into the past of the cat-human relationship by tackling three fundamental variables strongly influenced by the domestication process: genomes, food, and microorganisms. It will unravel how the increasing bond with humans across a wide spectrum of socio-cultural contexts, from prehistoric farming communities to the ancient Egyptian and Medieval societies, shaped the cat genome, leading to behavioural changes that turned cats into pets. It will examine how cats changed their nutritional behaviour while adapting to anthropized ecosystems, and document the temporal trajectories of pathogen infections in cats, shedding light on the rise of zoonotic diseases. This will offer unprecedented evolutionary insights on the debate about animal domestication, and will raise public awareness on the role of the cat as cherished pet, but also as one of the world’s most invasive alien species in natural ecosystems and host of infectious diseases recognized today as public health threats.

Keywords: domestication,paleogenomics,metagenomics,stable isotopes,paleodiet,zoonoses
E-FREE (Smart Solutions): Towards a more ECO, HEALTHY and SAFE environment in every single lighting scenario. (E-FREE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-04-01
End date: 2018-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

EKIONA is a company specialized in personalized solar lighting solutions. It develops, manufactures and commercializes Solar street lights located mainly in urban, residential, industrial, sports and recreational venues. EKIONA offers top lighting solutions for bicycle paths, pedestrian malls, country sides, sports fields, parks, rural paths, housing developments, roundabouts, roads, parking lots and similar applications. Since its foundation in 2010, several Solar Street Light projects have been carried out between EKIONA and some of the regions of Spain, including San Sebastian, Bilbao, Logroño, Madrid, Barcelona and Canary Islands. Currently, EKIONA is having traction from customers to include other packs in its Solar Street Lights. Spanish customers and also international customers, mainly customers from the Middle East (Qatar and UAE), are interested in integral solutions. Service Packs that are being requested are related to the improvement of the quality of life for citizen. Health care, security, sustainability and economy are being the figures that are considered in these service packs. The service packs are aimed to be sensor based systems that collect data from the environment, record it, analyse it and create results when possible. It is envisaged Solar Street Lights and add-on Systems on-line connected to Smart Cities and their frameworks. EKIONA is planning to perform pilot projects to check the logic and requirements of these systems. Pilot projects have been agreed with local governments from San Sebastian, Vitoria, Logroño and Madrid regions. The main objective in Phase I is to analyse possible ways to monetize those on-top services of the B2B and B2G business models that EKIONA has with Solar Street Lights and its potential markets.

Keywords: smart cities,environment,pollutionandclimate,energy economics,energy efficiency,energy systems,green procurement,zero carbon communities,photovoltaics,renewable energies,sustainable energies
Scalable Kinetic Models: From Molecular Dynamics to Cellular Signaling (ScaleCell)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-05-01
End date: 2024-04-30
Duration (months): 72.0
Total project cost (EUR): 1987500.0
EU funding (EUR): 1987500.0
Participants: 1
Project status: SIGNED

Biological processes are inherently multi-scalar: exchanging a single amino acid of a protein can affect the macroscopic behavior of a cell. A computational model that can cover these scales and simulate the time evolution of locations, interactions, and atomistic structures of biomolecules in a cell would be transformative for the understanding of biology and the optimization of biotechnological processes. This ERC project will lay the methodological groundwork for such a model. Recent breakthroughs in the long-standing problem of sampling rare transition events in molecular dynamics (MD) simulation have enabled us to simulate biomolecular processes such as folding and binding with atomistic models. The PI has co-pioneered the widely-used Markov State Models (MSMs) that combine extensive distributed MD simulations towards models of the molecular kinetics. Using these methods, we have demonstrated that protein-protein association can be simulated and timescales of seconds can be reached in all-atom models of small protein systems. However, these methods have fundamental limitations to scale to the large biomolecules and the long length-scales involved in cellular signaling. To address these limitations, we will develop the following key technologies and disseminate them in open software: 1. A model that describes protein kinetics as a network of local switches which will overcome scaling limitations of MSMs that suffer from an exponential increase of parameters for large systems. 2. An “effective force field for cells” that predicts structure and kinetics of multi-body protein interactions based on simulations of relatively few protein interactions. 3. A multi-scale method to embed atomistic kinetic models in whole-cell reaction-diffusion simulations. We will employ these methods and, in collaboration with leading experimentalists, investigate how the mechanochemical protein dynamin couples atomic-detail structure changes to membrane constriction in endocytosis.

Keywords: theory and method development in chemical physics and computational chemistry
eXtreme DataCloud (XDC)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: e-Infrastructures
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Italy,Poland,Switzerland,France,Netherlands
Call: Platform-driven e-infrastructure innovation (H2020-EINFRA-2017, 2017)
Start date: 2017-11-01
End date: 2020-04-30
Duration (months): 30.0
Total project cost (EUR): 3396875.0
EU funding (EUR): 3077000.0
Participants: 8
Project status: CLOSED

The eXtreme DataCloud (XDC) project will develop scalable technologies for federating storage resources and managing data in highly distributed computing environments. The services provided will be capable of operating at the unprecedented scale required by the most demanding, data intensive, research experiments in Europe and Worldwide. XDC will be based on existing tools (TRL8+) that the project will enrich with new functionalities and plugins already available as prototypes (TRL6). The targeted platforms are the current and next generation e-Infrastructures deployed in Europe, such as the European Open Science Cloud (EOSC), the European Grid Infrastructure (EGI), the Worldwide LHC Computing Grid (WLCG) and the computing infrastructures that will be funded by the upcoming H2020 EINFRA-12 call. The main high-level topics addressed by the project include: federation of storage resources with standard protocols, smart caching solutions, policy driven data management based on Quality of Service, data lifecycle management, metadata handling and manipulation, data preprocessing and encryption during ingestion, optimized data management based on access patterns. All the developments will be driven and tested against real life use cases provided by the consortium partners representing research communities belonging to a variety of scientific domains: Life Science, Astrophysics, High Energy Physics, Photon Science and Clinical Research. The XDC software will be released as Open Source platforms available for general exploitation.

Keywords: data management,access patterns,quality of service,police driven,orchestration,grid,cloud,onedata,dynafed,encryption,e infrastructures,dcache,paas,smart caching