Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A feasibility study for SYT-510, a first-in-class drug to treat neuropsychiatric disorders through restoring overall balance in brain chemistry (TWO-BIRDS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

PTSD affects over 15 million people in Europe. So far, 70% never find relief. New drugs that restore the endocannabinoid (endoCx) neural circuit hold potential to change this paradigm. Post-traumatic stress disorder, known as PTSD, is one of the most unforgiving psychological disorders. As victims of trauma, PTSD patients are coerced by their dysregulated brain chemistries to relive their traumatic experiences, where specific triggers provoke symptoms such as flashbacks, intrusive thoughts, nightmares and severe anxiety. Unfortunately, current drugs address only specific downstream neural circuits and are highly ineffective. The endoCx is highly dysregulated in PTSD, and as a 'master neuroregulator', drugs that restore its function in a safe and sustainable manner have strong potential to be the first effective treatment for PTSD. Synendos is a pharmaceutical start-up who have identified a new family of drugs that modulate the endoCx via a new mechanism-of-action. Termed SERIs, or, ‘selective endocannabinoid reuptake inhibitors’, these small molecule drugs regulate the endoCx system in a self-limiting manner, thereby restoring balance to brain chemistry without risk of drug dependency or cognitive disrepair. Our lead compound SYT-510 is at the stage of preclinical development, where it has demonstrated effective anti-anxiety activity, favourable pharmacokinetic characteristics and a strong safety profile. We aim to commercialize SYT-510 through establishing partnering deals with pharma companies for its co-development and eventual sales. With a patient population of over 30 million (in EU/US combined), PTSD is an attractive market for drug development. TWO-BIRDS project: The main aims of this feasibility study are to 1) work to further understand clinician and patient needs, 2) define a detailed plan for final preclinical, clinical and regulatory activities and 3) consolidate new information into an investor-ready business plan.

Keywords: ptsd,small molecule,endocannabinoid system,neuropsychiatric disorders,first in class,orally available,new mechanism of action,membrane transporter protein,tourette s syndrome
GNSS NAVIGATION THREATS MANAGEMENT (GATEMAN)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Italy,Spain,Finland
Call: Enabling Aviation Infrastructure: CNS (H2020-SESAR-2016-2, 2016)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 565743.75
EU funding (EUR): 565743.75
Participants: 5
Project status: CLOSED

GNSS will become the primary means of navigation in the mid and long term. However, GNSS signals are vulnerable to threats, specially to jamming and spoofing, which may cause the total loss of navigation, and hence the management of those threaths is a safety must. This project will research multiple measures that could be deployed on most aircrafts to enable the management of those threats, either on their own or in a collaborative fashion with other aircrafts. The measures to be researched will cover the threats detection, localisation and mitigation, the latter either to keep the GNSS-based navigation operative or to revert to an alternate PNT technology based on 5G cellular stations networks.
PJ24 VLD Network Collaborative Management (PJ24 NCM)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Austria,Germany,Germany,Spain,Ireland,Switzerland,Norway,Serbia,Croatia,Sweden,Sweden,Belgium,France,France,France,France,Netherlands,Denmark,United Kingdom,United Kingdom
Call: Network Collaborative Management (H2020-SESAR-2015-2, 2015)
Start date: 2016-11-01
End date: 2019-12-31
Duration (months): 38.0
Total project cost (EUR): 9454085.22
EU funding (EUR): 3760701.5300000003
Participants: 25
Project status: CLOSED

The Network Collaborative Management (NCM) project is based on a collaborative approach involving the whole spectrum of ATM actors: Airspace Users (AUs), Airports, Air Navigation Service Providers (ANSPs) and Network Manager (NM). In Air Traffic Flow and Capacity Management (ATFCM), the performance targets and expectations at the network and local level could to be better achieved only through a collaborative synchronised effort of all the involved actors. An important part of improving the performance of network operations is the effective and efficient planning of network resources, by linking local optimization processes (including airport processes) with network optimization processes, taking into account stakeholders’ preferences where possible. This facilitates also the innovative usage and application of fine-tuned tailored measures (including target times) to further enhance of performance. NCM is divided into four main focus areas: • Network perspective (with local input and support): Scenario Management (including Hotspot Awareness) • Local perspective (facilitated by network support): Tactical Capacity Management • Airspace User Preferences: feeding both local and network perspectives • Local-network integration: Airport Network Integration. NM can act as a reliable, dynamic and flexible binder between the building elements (ANSPs, Airports and AUs) of the new improved and highly interactive ATM system, where each element brings its own unique sine qua non contribution to the robustness of the entire structure. NCM is a trust building exercise designed to demonstrate the maturity of the integrated network and local concept elements including the interactions between all ATM actors. It will pave the way for the SESAR Deployment activities and the implementation of the future performance driven ATM environment in Europe, while fulfilling in the same time stakeholders’ different operational needs and requirements.

Keywords: collaborative,network,integration,local,airport,management
Dual Fuel Euro6 Engine Conversion Feasibility Study (E6 Evolution)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: United Kingdom
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

G-Volution has been a pioneer of the use of dual fuel technology in heavy road haulage vehicles in the UK and Europe, with current operators using dual fuel on a daily basis reporting real world CO2 emissions reduction of at least 15%, with consequent reductions in NOx and particulate emissions. The Company has invested heavily in development for more than 8 years, producing a range of patented technology. The new Euro 6 solution has been developed from GV’s patented Euro 5 solution, itself installed on a significant number of vehicle fleets, and demonstrated as part of the current Innovate UK Low carbon truck and refuelling infrastructure trial. Commercial developments over the last year or so have led to initial sales success through the acceptance of the technology as a solution that provides the qualities demanded for future transport Worldwide The objective of the overall project is to develop the current prototype Euro 6 prototype vehicle to provide the first commercially available retrofit solution for Euro6 engines. The strategic intent is to accelerate growth and increase penetration across Europe, USA and Asia by reducing the cost & increasing the reliability of the system while developing strategic partners in key European and World markets. This first part proposal intends to examine the feasibility and route to: Refine design for components and controls in line with OEM quality standards. Re-engineer ancilliary items to comply with OEM acceptable safety and other standards. Set targets for cost reduction based on market sizes and expectations and operating cost savings. Investigate, and set up, a suitable professional supply chain to meet cost targets and quality. Investigate certification and homologation routes for various territories/continents. Produce a marketing and delivery plan that addresses business model by territory. Carry out an IP inventory, both current and arising. Raise TRL from 5-6 to 8-9, market ready.

Keywords: road transport,heavy duty vehicles,alternative fuels,co2 reduction,lower pollutants nox,smoke,particulates,design for volume production,reduced capital cost,oem acceptance
NATIVE ROOTSTOCK (PISTACIA TEREBINTHUS) COMMERCIALISATION FOR SUSTAINABLE AND ECOLOGICAL MEDITERRANEAN CROPS, TO INCREASE EUROPEAN PISTACHIO MARKET COMPETITIVENESS (EUROPISTACIA)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Spain
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2016-04-01
End date: 2016-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

INCREASE EUROPEAN PISTACHIO MARKET COMPETITIVENESS, THROUGHT THE RECUPERATION AND COMMERCIALISATION OF NATIVE ROOTSTOCK (PISTACIA TEREBINTHUS) FOR THE MEDITERRANEAN CLIMATE Pistachio plant cultivation represents an important opportunity for European farmers, especially in the Mediterranean area, where there is a native rootstock that facilitates crop acclimation in arid areas with poor and dry soils, with easy operation, low probability of fungal diseases. These characteristics make the pistachio tree a competitive and suitable option for a sustainable cultivation in environmentally respectful methods of production. The biggest obstacle for expanding its cultivation is based on the absence of plant material which meets the requirements of the European market. Commercial varieties (selected male and female cultivars of Pistacia vera) are obtained by vegetative propagation and because the cuttings do not root a rootstock is needed. The recommended rootstock, Pistacia terebinthus, presents not only a lack of vigor and homogeneity but also a low germination rate (about 20 - 30% of seeds) which makes the start of cultivation more expensive and complicated. Furthermore, the grafting of the variety is traditionally performed in the field, when the rootstock has the size to match with the bud of the grafted variety. These technical difficulties prevent many potential new pistachio farmers from making the investment. Laimund has dedicated big efforts to the study of Pistacia terebinthus (or terebinth). The research was focussed on the in-vitro culture and resulted in various protocols for the initiation, multiplication and rooting of terebinth, concluding with the acclimatization of plants that are characterized by a high degree of homogeneity. The overall objective of Laimund is to become worldwide leader in commercializing pistachio plants adapted to Mediterranean climates which can be grown organically.

Keywords: rootstock,pistacia terebinthus plant,pistachio fruit,mediterranean,in vitro,plant,nursery
FIRE+ online interoperability and performance test tools to support emerging technologies from research to standardization and market launch The standards and innovations accelerating tool (F-Interop)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Switzerland,Switzerland,Belgium,France,France,France,France,Luxembourg,United Kingdom
Call: Integrating experiments and facilities in FIRE+ (H2020-ICT-2015, 2015)
Start date: 2015-11-01
End date: 2018-10-31
Duration (months): 36.0
Total project cost (EUR): 3897885.0
EU funding (EUR): 2998260.0
Participants: 14
Project status: CLOSED

F-Interop will develop and provide remotely accessible tools to support and accelerate standardisation processes and products developments, by offsetting several cost and time barriers. It will research and develop a new FIRE experimental platform to support the development of new technologies and standards, from their genesis to the market for: online interoperability tests and validation tools, remote compliance and conformance tests, scalability tests, Quality of Service (QoS) tests, SDN/NFV interoperability tools, Online privacy test tools, energy efficiency tools. F-Interop gathers standardisation partners together with 3 FIRE federations (Fed4FIRE, IoT Lab, OneLab) to build a common experimental platform as a service. Following an end-user driven methodology, it will directly address the needs of 3 emerging standards: oneM2M led by ETSI, 6TiSCH (IETF) chaired by our Inria partner, Web of Things WG (start Feb 2015) led by ERCIM-W3C, one of the project members. The open call will extend the platform to other standardisation activities, as well as to additional tools extensions and SME products validations. F-Interop will: - Provide online interoperability tools enabling research and development teams to test their products development and implementations at any time, without having to wait until the next face-to-face interop meeting. - Provide an online platform for standards compliance and labelling to be used by the IPv6 Forum Ready Logo Program and other similar labelling bodies, including ETSI, IETF and W3C. - Enable SME to accelerate interoperability and the development of their products and services. - Extend FIRE testbeds and bring them closer to the market. To achieve this ambitious objective, F.-Interop gathers a formidable combination of leading industry experts form standardisation bodies, research centres, FIRE testbeds and SMEs from Europe and Japan. The F-Interop Ecosystem will enable sustainable impact, commercial uptake and synergies at EU level.

Keywords: interoperability tests,testbed as a service,conformance tests,preformance tests,scalability tests,fire,testbeds federation,standardisation
Saving COOPerative Energy (SCOoPE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Spain,Spain,Spain,Spain,Spain,Italy,Spain,Spain,Spain,Spain,Italy,Greece,Sweden,France,Denmark,Portugal
Call: Organisational innovation to increase energy efficiency in industry (H2020-EE-2015-3-MarketUptake, 2015)
Start date: 2016-04-01
End date: 2019-03-31
Duration (months): 36.0
Total project cost (EUR): 1796003.75
EU funding (EUR): 1796003.75
Participants: 19
Project status: CLOSED

SCOoPE project will work directly with energy-intense agro-food industries to implement cross-cutting and collaborative energy management systems addressed to reduce their energy consumption, and will further spread this knowledge within technicians, businesses managers, and energy and agro-food institutions. The project SCOoPE aims at achieving the challenges of the topic EE 16-2014/2015. Regarding the use of cost-effective energy solutions, the project objective is to reduce energy consumption at a short term in a range between 10% and 15% directly in 81 businesses belonging to the agro-food target sectors of the project (namely crop drying, meat and poultry, dairy, and fruit and vegetables transformation). This reduction must be achieved without any decrease in the production capacity of the companies and maintaining correct socioeconomic and environmental conditions. In order to do that, the project will work with the uptake of specific and cross-cutting innovative technologies and techniques, which efficacy has been proven in other industrial sectors, different from agro-food sector, but that are not yet familiar to project’s target sectors. On the other hand, the project pursues larger savings in the medium term with new affordable energy solutions, specifically by developing the concept of “Collaborative Energy Management Systems”. It will take advantage of complementarities and synergies between analysed industrial sites with similar characteristics and will use them for the improvement of their joint energy efficiency. For this purpose, 6 pilot industrial clusters will be run in order to prove the improvements of total energy consumptions and its associated costs, achieved by using common procedures based on ISO 50.001 and supported by an specific software (Dashboard) developed by the project. All these experiences will be promoted to encourage target groups to reduce their energy consumption, following the example of the directly involved companies.

Keywords: benchmarikng,key performance indicators,collective energy management,key actors direct involvement,diagnosis ict tool,dashboard ict tool,drying arable crops,steam generation and pasteurization
Enhancing the innovation management capacity of SMEs in West Poland (KAM2WP_2020_2021)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Poland,Poland,Poland,Poland,Poland,Poland,Poland,Poland
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 91450.0
EU funding (EUR): 91450.0
Participants: 9
Project status: CLOSED

The objective of the project is to contribute to and enhance the innovation potential and innovation management skills within SMEs in the West Poland area. The project will follow a developed methodology to help the regional businesses to increase their innovation capacity and to innovate profitably. The project will be implemented via 2 specific schemes: 1) Service ‘Key account management for SME Instrument beneficiaries’ of Phase II /EIC Pilot. This service will be aimed at SMEs which will be successful in applying for the SME Instrument Programme under the Horizon 2020 (Phase II). Upon the receipt of the information from the EC/ EASME, the project partner will contact the potential beneficiary in order to explain the service and convince the SME to apply for the coaching scheme. 2) Service: ‘Enhancing the innovation management capacity of SME’s’. This service will be aimed at promising SMEs capable of growth and successful internationalisation that have real potential for innovation via proper development of their products, processes, services or business model but who lack the right skills, knowledge and experience to manage the innovation activities. The aim of this scheme is to first of all support those SMEs in order to make them unlock their potential for better management of the processes linked to innovation.

Keywords: mentoring,coaching,sme instrument,innovation management,support to innovation management,enhancing innovation,eimc,innovation and smes
Preparing for invasion: novel techniques for early detection of emerald ash borer (Agrilus planipennis) and discovering resistance traits in host plants. (EMERALD)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: SIGNED

Ash trees (Fraxinus spp.) in Europe are threatened by two alien invasive organisms; a deadly fungal pathogen Hymenoscyphus fraxineus that has been causing a slow, steady decline in Europe’s ash population, and emerald ash borer (EAB; Agrilus planipennis), a buprestid beetle that is quickly killing trees in eastern Europe, and moving west. There are fears that EAB will follow the same path as it did recently in USA – killing millions of ash trees, unless active research is undertaken to prevent the spread of EAB and protect the ash resource. EMERALD is a multidisciplinary and innovative project that approaches this invasion through the combination of molecular biology, analytical chemistry, sensor technology, insect ecology, and tree physiology to understand host-pest interactions and improve the options for integrated pest management in European forests. In this project, naïve and a co-evolved ash species will be investigated to understand their attractive volatile chemistry and influence on EAB’s behaviour and host preference (antixenosis), differences in host chemical defenses that either promote or deter EAB performance (antibiosis), and the confounding effect of H. fraxineus in relation to both interactions. Novel early detection tools will be developed including new lure traps and molecular assays based on optimized environmental DNA protocols of samples filtered from stem flow and canopy foliage, and portable loop mediated isothermal amplification (LAMP) to achieve point-of-use and real-time detection of EAB. The training-through-research will diversify and expand the skillset of the applicant, while also providing reciprocal teaching and new insights for the host unit. The results of this project will have tremendous value for European stakeholders and the general public for those concerned with saving the economically and ecological valuable ash in urban and rural forested environments by developing an arsenal of tools to manage the impending EAB invasion.

Keywords: host plant resistance,host plant volatiles,chemical ecology,forest entomology,secondary metabolites,insect performance,environmental dna,early detection,invasion biology