Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Early Universe Vacuum Stability and Beyond the Standard Model Physics (EUVSBSMP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Estonia
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 136582.8
EU funding (EUR): 136582.8
Participants: 1
Project status: CLOSED

The discovery of the Higgs boson marks the completion of a vibrant era of discoveries. With it we now posses a framework, the Standard Model (SM) of particle physics, with which to predict the behavior of elementary particles to unrepresented accuracy. Despite its success somewhat surprisingly there already exists strong evidence to suggest that the SM cannot be the complete theory of elementary interactions. For example, the vast majority of matter in the Universe seems to consist of a mysterious invisible component, dark matter, for which the SM gives no explanation. So far the Large Hadron Collider has provided few clues as to how to move the current understanding forward. Perhaps the most unexpected finding has been the implication that the current vacuum state of the Universe as predicted by the SM is not stable but in fact the world as we know it may collapse in a cataclysmic crunch when given enough time. Since the root cause of this vacuum instability lies in quantum mechanics the time it takes for this to happen is extremely long, much longer than the age of the Universe implying that this prediction is not in direct conflict with observations. However, when taking into account the current understanding of cosmology the situation changes drastically, as has been recently discovered: in the extreme conditions of the Early Universe a catastrophic collapse can become likely, which provides a window for probing and constraining elementary interactions by using cosmology and vice versa. In this action we propose to use this window to explore the rich landscape of beyond the SM physics, in particular, we suggest to make full use of its constraining power to obtain state-of-the-art bounds for well-motivated extensions of the SM. We also strive to explore the theoretical implications from the vacuum instability for Early Universe model building, including dark matter generation, as well as to solidify it as a method for obtaining novel observable predictions.

Keywords: vacuum stability,early universe
Predicting clinical response to anticancer drugs using 3D-bioprinted tumor models for personalized therapy (3DCanPredict)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-09-01
End date: 2021-11-30
Duration (months): 27.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Predicting clinical response to novel and existing anticancer drugs remains a major hurdle for successful cancer treatment. Studies indicate that the tumor ecosystem, resembling an organ-like structure, can limit the predictive power of current therapies that were evaluated solely on tumor cells. The interactions of tumor cells with their adjacent microenvironment are required to promote tumor progression and metastasis, determining drug responsiveness. Such interactions do not form in standard research techniques, where cancer cells grow on 2D plastic dishes. Hence, there is a need to develop new cancer models that better mimic the physio-pathological conditions of tumors. Here, we create 3D-bioprinted tumor models based on a library of hydrogels we developed as scaffold for different tumor types, designed according to the mechanical properties of the tissue of origin. As PoC, we bioprinted a vascularized 3D brain tumor model from brain tumor cells co-cultured with stromal cells and mixed with our hydrogels, that resemble the biophysics of the tumor and its microenvironment. Our patient-derived models consist of cells from a biopsy, constructed according to CT/MRI scans, and include functional vessels allowing for patients' serum to flow when connected to a pump. These models will facilitate reproducible, reliable and rapid results, determining which treatment suits best the specific patient's tumor. Taken together, this 3D-printed model could be the basis for potentially replacing cell and animal models. We predict that this powerful platform will be used in translational research for preclinical evaluation of new therapies and for clinical drug screening, which will save critical time, reduce toxicity and significantly decrease costs generating a major societal benefit. Our platform offers a highly attractive business case, as pharmaceutical and biotech companies heavily invest in preclinical predictive tools for novel personalized drug screening strategies.

Keywords: 3d bioprinting,high throughput screening,cancer diagnostics,drug response,drug combinations,tumor host interactions,tumor microenvironment tme,tumor heterogeneity,personalized medicine,companion diagnostics
Matrix glycans as multifunctional pathogenesis factors and therapeutic targets in cancer (GLYCANC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Egypt,Italy,Argentina,Germany,Greece,Hungary,Sweden,Korea, Republic of,Greece,France,Brazil
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-07-01
End date: 2019-06-30
Duration (months): 48.0
Total project cost (EUR): 567000.0
EU funding (EUR): 567000.0
Participants: 13
Project status: CLOSED

Cancer is a leading cause of mortality within the aging European population. Therapeutic targeting is hampered by the complexity of the disease, which includes not only molecular changes within the tumor cell itself, but also within its microenvironment. Tumor angiogenesis, tumor-stroma interactions, interactions with immune cells, with the extracellular matrix and cancer stem cell niches allow for malignant cell survival and promote metastasis, the leading cause for cancer-associated mortality. Proteoglycans (PGs) and glycosaminoglycans (GAGs) – structurally diverse carbohydrates of the extracellular matrix and cell surfaces - have emerged as novel biomarkers and molecular players both within tumor cells and their microenvironment, as they integrate signals from growth factors, chemokines and integrins, and cell-cell as well as matrix adhesion. Importantly, their expression is dysregulated in numerous tumor entities, and has been shown to modulate each of the hallmarks of cancer as defined by Hanahan and Weinberg (Cell 2011). We hypothesize that dysregulated function of PGs and GAGs simultaneously affects all molecular steps towards cancer metastasis as a general principle applicable to multiple tumor entities. Pharmacological modulation of their function thus emerges as an attractive multitargeted antitumoral approach which simultaneously acts at multiple levels of disease progression. Besides providing extensive knowledge transfer and training for researchers, the combined expertise of the GLYCANC consortium aims at performing a detailed structural analysis of PG and GAG glycans in disease using state-of-the art methodology, analysing their regulation via epigenetic mechanisms and microRNAs, and elucidating molecular mechanisms underlying aberrant PG and GAG function. GLYCANC will lead to a deeper understanding of glycan structures and glycan-dependent mechanisms promoting cancer progression, providing the basis for rational multitargeted anticancer approaches.

Keywords: proteoglycans,glycosaminoglycans,heparan sulfate,hyaluronan,glycobiology,metastasis
COmbined suN-Driven Oxidation and CO2 Reduction for renewable energy storage (CONDOR)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Italy,Italy,Belgium,France,Czechia,Netherlands,United States,Netherlands
Call: Developing the next generation of renewable energy technologies (H2020-LC-SC3-2020-RES-RIA, 2020)
Start date: 2020-11-01
End date: 2024-10-31
Duration (months): 48.0
Total project cost (EUR): 4087866.25
EU funding (EUR): 3989116.25
Participants: 11
Project status: SIGNED

Conversion of sunlight into fuels and mitigation of anthropogenic climate change are big scientific challenges. CONDOR addresses both of them by developing highly efficient solar-driven conversion of CO2 into fuels and added-value chemicals. We propose a photosynthetic device made of two compartments (a) a photoelectrochemical cell that splits water and CO2 and generates oxygen and syngas, a mixture of H2 and CO; (b) a (photo)reactor that converts syngas into methanol and dimethylether (DME), via bi-functional heterogeneous catalysts. The proposed modular approach enables different configurations depending on the target product. The oxidation process is not limited to O2 production, but entails chlorine and small organic molecules, such as 2,5-furandicarboxylic acid, derived from the oxidation of low-cost and easily available precursors like salt water or alcohol derived biomass, respectively. Employed materials will be obtained through low energy/low temperature routes, mainly based on wet chemical procedures, such as sol-gel chemistry, mild hydrothermal processes, electrochemical processes at ambient temperature. Raw materials/precursors will not be limited by availability on a global scale, making use of organic species, silicon, earth abundant metal oxides, first row transition metals. The final target is a full photosynthetic device with 8% solar-to-syngas and 6% solar-to-DME efficiencies with three-months continuous outdoor operation. This represents a large progress with respect to the state of the art and requires an international collaboration and a multidisciplinary approach, which integrates expertise in nanomaterials preparation and characterisation by operando microscopy and spectroscopy, homogeneous and heterogeneous catalysis, photochemistry/photoelectrochemistry, PEC engineering and assessment of the environmental and socio-economic impact of the proposed technology, including life cycle assessment.

Keywords: artificial photosynthesis,photoelectrochemical cell,heterogeneous catalysis,syngas,solar fuel,electrocatalysis
The World of the Gáidhealtachd and the origins of the Early Modern British State, 1513-1594. (GEMS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

By 1603 the political power of the Gaelic world, or Gáidhealtachd, had been broken in the face of the recently created British state. Though certain Gaelic dynasties (i.e., the Campbells and O’Briens) actively worked with the state, little research has been undertaken on how dynasties such as the O’Donnells and O’Neills possessed the capacity not only to resist but also to threaten this process of state formation throughout the 16th century. Using a series of case studies and drawing upon a broad base of primary material, this project explores the political and military development of the Gáidhealtachd during two key phases of Anglo-Scottish relations. The first section investigates how certain Gaelic lords manipulated the course of Anglo-Scottish hostilities from 1513-59 in order to enhance their position within ‘British’ politics. The second section explores how the Gaelic lords reacted to the development of Anglo-Scottish peace and amity from 1560-94. The main objective of this project is therefore to uncover the basis for the strong level of Gaelic political and military resilience within ‘British’ politics throughout the 16th century and how significant a factor this was in contributing to the outbreak of the Nine Years War (1594-1603). This is an interdisciplinary project, involving Gaelic, English, Scottish, and Latin historical material as well as elements of literature and archaeology. The project will be strengthened by the experienced interdisciplinary research team at the University of Glasgow and will involve both the transfer of knowledge to the host institution and the training of the researcher in new competences. Ultimately, this project will make a major intervention in the history of Early Modern Ireland and Britain and will result in a series of high-impact publications. The proposal also entails a secondment to BBC Scotland and a detailed public engagement strategy aimed at changing public perceptions of 16th century Ireland and Britain.

Keywords: late medieval,early modern irish and british history,gaelic irish and gaelic scottish history,atlantic world history,state formation in early modern ireland and britain
Merging organo- and gold-catalysis to design cascade reactions: a shortcut toward molecular complexity (ORGANO-GOLD CAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-01
End date: 2017-05-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

We are in a changing era for drug discovery: the growing perception is that basic chemical research will play a greater role in pharmaceutical development. One current challenge is to develop a new kind of chemistry that yields a screening collection comprising optimal chiral molecules that increase the probability of success in identifying drug-candidate structures. The proposed research aims to develop conceptually innovative catalytic methods to rapidly generate, in one single step, architecturally complex chiral natural-like compounds. Natural products have been selected in evolution and their underlying structural scaffolds define biologically relevant fractions of chemical space. Consequently, compound libraries inspired by natural structures deliver lead candidates with a higher hit-rate than conventional lead generation strategies. We will pursue the proposed research project under the guiding principle that compound development should be driven by discoveries and innovation in chemical methodology. The goal of the research project is to combine the potential of asymmetric organocatalysis and gold catalysis, powerful fields of molecule activation, to find cost-effective synthetic methods for reproducing the rich structural diversity of natural molecules. Since the vast majority of natural products and drug-like compounds possess heterocyclic moieties, we will focus on preparing diverse heterocyclic compounds, especially based on the furan unit. The resulting synthetic platform will be used as an ideal starting point for assembling enantiopure chiral 2,3-furan fused carbocycles, which, along with biological screening carried out in collaboration with a world-wide recognized pharma-company (Lundbeck A/S), will increase the probability of success in identifying drug-candidate structures. The multi-cultural nature of this project will greatly contribute to broaden the fellow competencies and will place him in an excellent position for the next career move

Keywords: cascade reactions,gold catalysis,organocatalysis,enantioselective catalysis,drug discovery
Smart Technologies for personAlised Nutrition and Consumer Engagement (Stance4Health)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive agri-food sector for a safe and healthy diet
Action type: Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Italy,Germany,Germany,Spain,Spain,Italy,Belgium,Greece,Greece,Greece,Romania,Denmark,United Kingdom
Call: Personalized Nutrition (H2020-SFS-2018-1, 2018)
Start date: 2018-10-01
End date: 2023-06-30
Duration (months): 57.0
Total project cost (EUR): 6921141.08
EU funding (EUR): 6393489.51
Participants: 19
Project status: SIGNED

The overall objective of Stance4Health is to develop a complete Smart Personalised Nutrition (SPN) service based on the use of mobile technologies as well as tailored food production that will optimize the gut microbiota activity and long-term consumer engagement. The Stance4Health consortium consists of 19 partners from 8 European countries (Spain, Germany, Denmark, Romania, Italy, Greece, Belgium, UK). Six SMEs will be in charge of the development and future commercialisation of the novel SPN service, including 2 new apps for personalised nutrition, integration of a wearable device for daily analysis of one’s body composition, 9 tailored cereal-derived foods for specific (vulnerable) consumer groups (overweight, coeliac disease or food allergy, adults, children), 6 individualised dietary supplements for adults, and 1 nutraceutical and 1 in vitro diagnostic test to control the gut microbiota activity. These novel tools and services have the potential to directly impact more than 67 million European adults and 8 million children by 2022, at a monthly cost of only 0.99€ (for the app).

Keywords: personalized nutrition,gut microbiota,consumer engagement,intersectional analysis
A cybersecurity framework to GUArantee Reliability and trust for Digital service chains (GUARD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Germany,Italy,Italy,Germany,Austria,Spain,Italy,Cyprus,Greece,Poland,Bulgaria
Call: Dynamic countering of cyber-attacks (H2020-SU-ICT-2018, 2018)
Start date: 2019-05-01
End date: 2022-04-30
Duration (months): 36.0
Total project cost (EUR): 5448071.43
EU funding (EUR): 4684700.0
Participants: 16
Project status: CLOSED

Evolving business models are progressively reshaping the scope and structure of ICT services, with massive introduction of virtualization paradigms and tight integration with the physical environment. Several market forces are already driving towards the creation of multi-domain and complex business service chains, which undoubtedly bring more agility in service deployment and operation but introduce additional security and privacy concerns that have not been addressed in a satisfactory way yet. Tackling conflicting trends in the cybersecurity market, like fragmentation or vendor lock-ins, GUARD will develop an open and extensible platform for advanced assurance and protection of trustworthy and reliable business chains spanning multiple administrative domains and heterogeneous infrastructures. The purpose of GUARD is manifold: i) to increase the information base for analysis and detection, while preserving privacy, ii) to improve the detection capability by data correlation between domains and sources, iii) to verify reliability and dependability by formal methods that take into account configuration and trust properties of the whole chain, and iv) to increase awareness by better propagation of knowledge to the humans in the loop. The distinctive approach of GUARD will be the architectural separation between analysis and data sources, mediated by proper abstraction; this paradigm will result in an open, modular, pluggable, extendable, and scalable security framework. This holistic solution will blend security-by-design with enhanced inspection and detection techniques, raising situational awareness at different levels of the companies’ structure by tailored informative contents, so to enable quick and effective reaction to cyber-threats. Demonstration and validation in two challenging scenarios is envisioned to bring the technology to an acceptable level of maturity, as well as direct involvement of relevant stakeholders for concrete business planning.

Keywords: digital service chains,cross domain programmatic security and trustworthiness,user centric awareness and mitigation,threat detection and information sharing
Strengthening European integration through the analysis of conflict discourses: revisiting the past, anticipating the future (RePAST)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Reflective societies - cultural heritage and European identity
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Ireland,Cyprus,Norway,Belgium,Greece,Slovenia,Poland,Greece,United Kingdom,Denmark
Call: Improving mutual understanding among Europeans by working through troubled pasts (H2020-SC6-CULT-COOP-2017-two-stage, 2017)
Start date: 2018-05-01
End date: 2021-10-31
Duration (months): 42.0
Total project cost (EUR): 2497359.66
EU funding (EUR): 2497359.66
Participants: 13
Project status: CLOSED

RePAST aims at investigating how European societies deal with their troubled pasts today through the analysis of conflict discourses rooted in those pasts, with a view on the impact of those discourses on European integration. It will implement actions and propose strategies, both at the levels of policy-making and civil society, for reflecting upon these discourses to strengthen European integration. The project addresses directly the specific challenge and scope of the topic CULT-COOP-02-2017, focusing on civil society, informal education and political discourses. The methodological approach of RePAST is based on (i) multidisciplinarity, (ii) cross-country comparative analysis and (iii) innovative actions for citizens’ engagement with troubled pasts. First, conflict discourses rooted in troubled pasts will be studied in four fundamental spaces of civil society and sources of informal education: (a) history (oral and official), (b) media (journalistic- and citizen-led media), (c) art and culture, (d) politics (formal and informal politics). It will also take into account how the current crisis in its multiple forms (economic crisis, refugee crisis, political crisis) mediates these narratives. RePAST brings the various disciplines in dialogue with each other on the ground of an empirical study across the geographical and historical spectrum. Second, RePAST will study comparatively eight cases of countries whose troubled pasts sit squarely on legacies that still endanger European integration today: Cyprus, Germany, Poland, Greece, Bosnia, Kosovo, Ireland, and Spain. Lastly, RePAST emphasizes the active engagement of memory agents through a series of innovative actions for creating participatory experiences, i.e. interactive storytelling, research tool for analysis on memory and conflict, webinars for cultural tourism professionals, a quiz game tour to discover troubled pasts, and digital games for renegotiating troubled pasts.

Keywords: memory conflict contested past integration crisis