Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A global multi-institutional Typhoid fever genomic surveillance network to improve global public health outcomes (TyphiNET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Globally there are ~20 million typhoid fever cases per year, resulting in ~200,000 deaths from infection with the causative agent, Salmonella Typhi. Antimicrobial therapy is the mainstay of typhoid fever control, and genomic epidemiology studies have revealed that drug resistance emerging in one country can rapidly spread to other neighbouring countries and intercontinentally. Genomic and phenotypic surveillance for typhoid and antimicrobial resistance (AMR) is therefore very important for disease control. TyphiNET aims to develop innovative approaches to bring the benefits of typhoid genomic surveillance to LMICs where the disease is endemic through three main goals: (1) to unlock data from travel-associated typhoid cases in high income countries that are adopting genomics for routine Salmonella surveillance (2) to unlock data from project-based genomic surveillance in endemic areas (beginning with five key collaborative projects across Asia and Africa) and (3) develop an open access publicly available platform for synergising, visualising, and disseminating large scale genomic data sourced from sentinel and endemic area surveillance. Research questions will include inferring genomic epidemiology parameters (prevalence of strain types, resistance to specific antimicrobials, and regional transmission patterns) for different countries/regions using data from sentinel surveillance and from endemic area surveillance; comparison of these to demonstrate the utility of sentinel traveller surveillance for predicting endemic area disease patterns; and comparison of disease dynamics between regions. Outcomes will inform management of both endemic disease in LMICs and travel-associated cases elsewhere, including providing region- and country-specific data to inform empirical antimicrobial choice; and will reveal coverage gaps in endemic area surveillance to be targeted in future studies.

Keywords: typhoid fever,genomic epidemiology,antimicrobial resistance,travel associated infection,bacterial pathogens,public health,infectious disease,global health,salmonella
LABEL FREE IMAGING WITH PHI-SCAT (LABELFREE)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Netherlands
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-03, 2018)
Start date: 2019-05-01
End date: 2021-04-30
Duration (months): 24.0
Total project cost (EUR): 106562.5
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

We will launch phi-SCAT, a novel imaging technology, which uniquely allows for label-free imaging of biological structures of interest. We will do this by productizing the interferometric scattering technology that was invented in course of the Chromavision FET-OPEN project. Proof-of-concept data has been obtained in the FET-OPEN project, and proved the technology’s value, complementary to existing imaging methods that are either low contrast or depend on fluorescent labels. The project will focus on the steps needed for the market launch of this novel technology. We will follow two parallel trajectories for exploitation: firstly we will implement and launch a phi-SCAT module on our existing C-Trap single-molecule analysis product line. Secondly we will approach potential licensing partners for implementation of the phi-SCAT technology on existing microscope platforms. This project will result in a valuable valorisation of one of the most significant innovations that stemmed from the Chromavision FET-OPEN project. Besides significant positive impact on our C-Trap product line’s turnover and gross margin, the application of this more effective microscopy method in academic and pharmaceutical research will have profound impact on the understanding of key biological processes and contribute greatly to optimization of the drug discovery process
Digital Hybrid Breast PET/MRI for Enhanced Diagnosis of Breast Cancer (HYPMED)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Austria,Germany,Germany,Germany,Germany,France,Netherlands,Netherlands,Netherlands
Call: Development of new diagnostic tools and technologies: in vivo medical imaging technologies (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2022-06-30
Duration (months): 78.0
Total project cost (EUR): 5861957.5
EU funding (EUR): 5861957.5
Participants: 10
Project status: CLOSED

Breast cancer represents a leading cause of cancer death in women and a major socio-economic issue. With currently available methods, early diagnosis frequently fails. Moreover, beyond mere detection, there is an ever-increasing need for improved non-invasive characterisation of cancer. Targeted therapies require an in-depth analysis of cancer to select and guide appropriate treatment. Both, PET and MRI can provide molecular and functional information that may be of pivotal importance for tailoring therapy. However, current whole-body PET/MRI systems lack the necessary sensitivity and resolution for this task. HYPMED addresses this by engineering an innovative imaging tool. HYPMED will integrate an innovative fully-digital MRI-transparent PET-detector into a novel multi-channel PET-transparent MRI surface coil. The PET-RF insert will allow unprecedented imaging of breast cancer with high-resolution/ultra-high sensitivity PET, combined with high-level structural and functional MRI, and allow minimal-invasive MR- and PET-guided targeted biopsy. Moreover with such PET-RF inserts, every regular clinical MR-system can, upon demand, be turned into a hybrid system. We will evaluate the impact of this technology on breast cancer diagnosis, prediction, and monitoring/assessment of treatment response by a carefully designed clinical study that employs established and novel PET tracers in 250 patients. Imaging data will be correlated with established and novel molecular biomarkers; results will be compared to those obtained from whole-body PET/MRI and PET/CT. A multidisciplinary consortium of clinical scientists, 3 SMEs and an industry partner will pave the way for commercialization of HYPMED products for advanced clinical decision making in cancer patients. Once HYPMED is successful, we will expand this approach to other applications such as prostate cancer or cardiac hybrid imaging, and thus introduce a paradigm shift in the field of PET/MR hybrid imaging as a whole.

Keywords: breast cancer,simultaneous pet,molecular imaging
The Flexible Genome: understanding the genetic regulation of Phenotypic Plasticity. (FLEXGENOME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-15
End date: 2017-04-14
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

In multicellular animals, complex phenotypic traits such as behaviour, lifespan and diseases are not only determined by genetic factors but also in large part by the environment. Understanding how genes and the environment interact to produce fundamental traits is a major question in biology. Many organisms are capable of expressing multiple phenotypes from a single genome when exposed to different environments. This widespread phenomenon is termed phenotypic plasticity (PP). The genetic programs needed to produce alternative phenotypes are encoded within a single genome, and environmental stimuli determine which form is expressed. PP is highly relevant in nature as it allows organisms to survive and reproduce successfully in variable environments. Nevertheless, the molecular and genetic mechanisms responsible for this flexibility are surprisingly poorly understood. Here, I will investigate the genetic basis of PP by applying advanced genomic and computational techniques to an ecological model of PP, the butterfly Bicyclus anynana. In particular, I will 1) identify the genetic programs that produce alternative phenotypes from a single genome; and 2) assess the potential for evolutionary change in PP by characterising genetic variation in these programs. I will do this by applying RNA-Seq and gene co-expression networks to an ecologically well-characterised insect and developing and integrating methods and concepts across disciplines. Combining my significant expertise on the model system with the host laboratory’s outstanding track record in evolutionary genomics and bioinformatics, this project offers a unique opportunity for obtaining an unprecedented and long-desired insight into the genetic mechanisms of PP. This fellowship will train me in precisely the technical and analytical techniques that are critical for scientific progress in decades to come, and for my career development as a scientist within the European Research Area.

Keywords: phenotypic plasticity,gene environment interaction,evolutionary ecology,evolutionary transcriptomics,bioinformatics,adaptation,life history,genetic architecture,climate change
EQ Supreme is the cost-effective, ultra-thin silage stretch wrap able to completely eliminate feed losses due to mould. (EQ Supreme)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Ireland
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-09-01
End date: 2017-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Since the introduction of the bale wrapping system in the mid 1980's, baled silage has become the handier and most common system to store silage and hay across Europe. Since then, silage stretch wrap has come a long way and now hundreds of millions bales are wrapped every summer in the EU. EQ Supreme by RapFast is the next major advance in this on-going evolution, employing the very latest polymers and film manufacturing technology. EQ Supreme is the first stretch wrap to completely exclude the air, so lactic acid fermentation can take place within the bale, leaving a feed rich in vitamins and carotene. While preserving the nutritional value of the ensiled crop, EQ Supreme’s superior air barrier completely eliminates the spoilage, reducing storage losses. In order to provide the ideal ensiling environment silage stretch films need to offer a number of important elements such as strength, puncture and tear resistance, elasticity, UV stability and the ability to cling in all circumstances. If just one of these features is missing a film will not perform effectively. EQ Supreme optimises these elements to provide the best collective performance, while reducing the film profile thickness. Only 18 μm thick, EQ Supreme is robust enough to withstand the rigorous handling of modern, complex wrapping machinery. Finally, EQ Supreme is specifically designed not to neck down (width reduction) when applied to the bale. This is very unlike traditional stretch films, which can have up to a 25% width reduction, meaning that the bale has to be wrapped with many more revolutions in order to achieve an acceptable wrapped bale. An extra cost that EQ Supreme definitely avoids.

Keywords: storage losses,food safety,waste reduction,productivity
Preserving Wooden Heritage. Methods for monitoring wooden structures: 3D laser scanner survey and application of BIM systems on point cloud models (PresWoodenHeritage)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Finland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-01
End date: 2019-10-07
Duration (months): 24.0
Total project cost (EUR): 179325.6
EU funding (EUR): 179325.6
Participants: 1
Project status: CLOSED

Wooden Heritage has been recognized today as an object of growing interest in scientific research even on international scale, not only from the architectural point of view but also from theoretical approaches. Over the times many technological systems concerning timber have evolved, refined and defined in the use of mixed solutions. Wooden Architecture represents one of the oldest building systems adopted by the majority of people who developed construction techniques respecting the local traditions. Today this vast and unique wooden heritage needs urgently survey and cataloguing. Fires and abandonment are the main factors jeopardizing the preservation of this architecture; every year too many wooden buildings still disappear because of this negligence. This important challenge has the purpose to obtain new technical methods, procedures and protocols that don’t exist yet, fundamental for technicians and operators. The research project wants to address a new scientific approach on wooden buildings. This is aimed for practical interventions for with respect to the scientific and epistemic foundations, by improving 3D laser scanner survey and photo-modelling activities through post production phases with parameterization of the point cloud to create 3D digital models queried and enriched by informative content and increase BIM (Building Information Modeling) knowledge. The main and most important contribution of this project is the accomplishment of scientific, technical and operational systems and tools for the documentation of wooden structures. During the process of analysis different experts belonging from the best host companies chosen, will guide, check and develop jointly with the applicant all the methods, procedures and theoretical background for achieving the best results in a successful project. In this way the triangle Research-Theory-Practice will offer new insights to timber architecture, to the preservation and maintenance of the wooden heritage.

Keywords: laser scanner,wooden architecture,cultural heritage,digital models,bim systems,timber structures,block bau,survey,operative protocols
Turning the cortically blind brain to see: from neural computations to system dynamics generating visual awareness in humans and monkeys (LIGHTUP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Italy,Belgium,Netherlands,United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-08-01
End date: 2024-07-31
Duration (months): 72.0
Total project cost (EUR): 1994212.0
EU funding (EUR): 1054564.37
Participants: 4
Project status: SIGNED

Visual awareness affords flexibility and experiential richness, and its loss following brain damage has devastating effects. However, patients with blindness following cortical damage may retain visual functions, despite visual awareness is lacking (blindsight). But, how can we translate non-conscious visual abilities into conscious ones after damage to the visual cortex? To place our understanding of visual awareness on firm neurobiological and mechanistic bases, I propose to integrate human and monkey neuroscience. Next, I will translate this wisdom into evidence-based clinical intervention. First, LIGHTUP will apply computational neuroimaging methods at the micro-scale level, estimating population receptive fields in humans and monkeys. This will enable analyzing fMRI signal similar to the way tuning properties are studied in neurophysiology, and to clarify how brain areas translate visual properties into responses associated with awareness. Second, LIGHTUP leverages a behavioural paradigm that can dissociate nonconscious visual abilities from awareness in monkeys, thus offering a refined animal model of visual awareness. Applying behavioural-Dynamic Causal Modelling to combine fMRI and behavioral data, LIGHTUP will build up a Bayesian framework that specifies the directionality of information flow in the interactions across distant brain areas, and their causal role in generating visual awareness. In the third part, I will devise a rehabilitation protocol that combines brain stimulation and visual training to promote the (re)emergence of lost visual awareness. LIGHTUP will exploit non-invasive transcranial magnetic stimulation (TMS) in a novel protocol that enables stimulation of complex cortical circuits and selection of the direction of connectivity that is enhanced. This associative stimulation has been proven to induce Hebbian plasticity, and we have piloted its effects in fostering visual awareness in association with visual restoration training.

Keywords: blindsight,visual awareness,cortical blindness,striate cortex,fmri,computational neuroimaging
Secure and Resilient Cloud Architecture (SafeCloud)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Action type: Innovation actions
Countries involved: Germany,Germany,Estonia,Switzerland,Portugal,Portugal,Portugal
Call: Privacy (H2020-DS-2014-1, 2014)
Start date: 2015-09-01
End date: 2018-08-31
Duration (months): 36.0
Total project cost (EUR): 3298987.5
EU funding (EUR): 2150810.0
Participants: 7
Project status: CLOSED

Cloud infrastructures, despite all their advantages and importance to the competitiveness of modern economies, raise fundamental questions related to the privacy, integrity, and security of offsite data storage and processing tasks. These questions are currently not answered satisfactorily by existing technologies. Furthermore, recent developments in the wake of the expansive and sometimes unauthorized government access to private and sensitive data raise major privacy and security concerns about data located in the cloud, especially when data is physically located, processed, or must transit outside the legal jurisdiction of its rightful owner. This is exacerbated by providers of cloud services that frequently move and process data without notice in ways that are detrimental to the users and their privacy. SafeCloud will re-architect cloud infrastructures to ensure that data transmission, storage, and processing can be (1) partitioned in multiple administrative domains that are unlikely to collude, so that sensitive data can be protected by design; (2) entangled with inter-dependencies that make it impossible for any of the domains to tamper with its integrity. These two principles (partitioning and entanglement) are thus applied holistically across the entire data management stack, from communication to storage and processing. Users will control the choice of non-colluding domains for partitioning and the tradeoffs between entanglement and performance, and thus will have full control over what happens to their data. This will make users less reluctant to manage their personal data online due to privacy concerns and will generate positive business cases for privacy-sensitive online applications such as the distributed cloud infrastructure and medical record storage platform that we address.

Keywords: cloud computing,data storage and management,integrity,availability
Solution Processed OLEDs for Lighting (SOLEDLIGHT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Micro- and nanoelectronics and photonics: Key enabling technologies related to micro- and nanoelectronics and to photonics, covering also quantum technologies
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Switzerland,Belgium,France,France,Netherlands,United Kingdom
Call: Development of novel materials and systems for OLED lighting (H2020-ICT-2014-1, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 4467521.25
EU funding (EUR): 3692521.25
Participants: 9
Project status: CLOSED

Highly efficient organic electroluminescent devices (OLEDs) are a technology that promises to reduce significantly the electricity consumption. The estimated market for OLED lighting products is large ($8 billion) and European lighting manufacturers are ideally positioned to capture a large part of it. Glass OLED products prepared by vacuum evaporation techniques have been demonstrated with good performances, yet the main bottle neck for larger market introduction is the high cost. At high production volumes the cost of OLED production is directly related to the efficiency of materials usage which is estimated to be 70 % for vacuum deposition and 90 % via solution processing. Hence, roll-to-roll solution processed OLEDs, will lead to a significant price reduction due to more efficient organic material usage, lower capital investments and higher throughput. Additionally, these OLEDs will be produced directly on flexible substrates allowing for new light weight and space saving designs. SOLEDLIGHT will develop hybrid and fully S2S and R2R solution processed multilayer OLEDs with power efficiencies > 100 lm/W and lifetimes > 15000 hours at 3,000 cd/m2. This will be addressed by: • New emitter and charge transport materials • Methods to control multilayer stack formation. • Interface and emitting layer morphology control. • Implementing large-area roll-to-roll solution processing. • Demonstration of flexible OLEDs integrated into a luminaire. SOLEDLIGHT will scale up both the chemical synthesis of these material systems and the R2R coating technology to a pilot production line. SOLEDLIGHT has assembled a consortium comprising a Osram (leading OLED manufacturer and integrator), Solvay (leading OLED materials manufacturer), TNO/Holst Centre (an excellence centre for organic devices with a state-of-the-art R2R line and leading universities in the field (Univ. Valencia, EPFL and Imperial College). The participation of Osram ensures a rapid transfer to future products.

Keywords: solution processed,oleds,lighting,high performance