Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ERA-NET rare disease research implementing IRDiRC objectives (E-Rare-3)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: ERA-NET Cofund
Partnership: E-Rare-3 (ERA-NET)
Countries involved: Austria,Germany,Italy,Italy,Israel,Germany,Spain,Greece,Hungary,Poland,Switzerland,Türkiye,Belgium,Romania,Latvia,France,Netherlands,Canada,Portugal
Call: ERA NET rare disease research implementing IRDiRC objectives (H2020-HCO-2014, 2014)
Start date: 2014-12-01
End date: 2020-11-30
Duration (months): 72.0
Total project cost (EUR): 23290000.0
EU funding (EUR): 5884310.0
Participants: 27
Project status: CLOSED

Rare diseases (RD) are diseases that affect not more than 5 per 10 000 persons (according to the EU definition). 7000 distinct rare diseases exist, affecting between 6% and 8% of the population (about 30 million EU citizens). The lack of specific health policies for rare diseases and the scarcity of the expertise, translate into delayed diagnosis, few medicinal products and difficult access to care. That is why rare diseases are a prime example of a research area that strongly profits from coordination on a European scale. At present only few European countries fund research on rare diseases through specific dedicated programmes. Therefore, the funding of transnational collaborative research is the most effective joint activity to enhance the cooperation between scientists working on rare diseases in Europe and beyond. The E-Rare consortium was built to link responsible funding bodies that combine the scarce resources and fund rare disease research via Joint Transnational Calls (JTCs). The current E-Rare-3 project proposal will extend and strengthen the transnational cooperation by building on the experience and results of the previous E-Rare-1&2 programmes. The consortium comprises 26 institutions from 17 European, Associated and non-European countries. Its international dimension will be directly translated into close collaboration with IRDiRC and other relevant European and international initiatives. IRDiRC guidelines and policies will be implemented in the four JTCs and representatives of the IRDiRC Scientific Committees will be invited to join the Advisory Board of E-Rare-3. Members of the EUCERD group will be involved in identifying rare disease research needs. Patients’ organizations from Europe (represented by EURORDIS) and beyond will be invited as a key partner towards collaborative efforts for research promotion and funding. The collaboration with European Research Infrastructures will be consolidated to enhance efficient and participative research.

Keywords: cofund,era net,collaboration,irdirc,joint transnational call,harmonization,natural history of rare diseases,disease mecanisms,diagnostic tools
Effective management of pregnant cancer patients through a cloud-based integrative and highly specialized advisory board platform (NIMBUS4CIP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2020-03-01
End date: 2021-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Although cancer in pregnancy (CIP) is rare (one in 1000-2000 pregnancies), it has an important impact on society as it annually affects more than 200,000 pregnant women worldwide. The ERC-CoG project “CRADLE”, has led to the finding that management of cancer in pregnancy requires a specialized multidisciplinary care of not only physicians within the oncology field but also in gynaecology, obstetrics, perinatology and psychology. However, as CIP is a rare event, most physicians are rarely confronted with pregnant women with cancer and therefore, lack the expertise manage these cases. Moreover, many geographical and logistic barriers might impede community-based hospitals and/or patients access to multidisciplinary tumour boards in referral hospitals. This results in a staggering number of patients that are treated with suboptimal care. As a result of these findings, Prof. Amant and his CRADLE team spearheaded the creation of an email-based Dutch-Belgian tumor advisory board, that is highly integrative and specialised in the cancer in pregnancy field. The main aim of this board is to remotely discuss CRADLE cases but also to provide specialized advice to hospitals without specialized resources or with important geographical and logistic barriers. In NIMBUS4CIP, we plan to validate the societal and commercial value of this Dutch-Belgian cancer in pregnancy platform. First, we will technically optimize the board by creating a web-based software (weCRADLE) that will streamline and improve the efficiency of case management. Next, we will validate in a prospective pilot study whether patient management using weCRADLE leads to improved oncological, obstetrical and neonatal outcomes. Finally, we will evaluate weCRADLE’s intellectual property position and the commercialization potential as a tool to remotely offer support to non-specialized physicians.

Keywords: tumor board,software,cancer,pregnancy
An alliance of European marine research infrastructure to meet the evolving needs of the research and industrial communities. (EurofleetsPlus)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Estonia,Iceland,Spain,Germany,Germany,Spain,Italy,Italy,Ireland,Ireland,Sweden,Norway,Norway,Türkiye,Belgium,Finland,Greece,Poland,Romania,New Zealand,Belgium,France,Netherlands,United States,Netherlands,Portugal,Denmark,Canada,Denmark,Faroe Islands,Greenland,United Kingdom
Call: Integrating Activities for Advanced Communities (H2020-INFRAIA-2018-1, 2018)
Start date: 2019-02-01
End date: 2023-10-31
Duration (months): 57.0
Total project cost (EUR): 9999360.58
EU funding (EUR): 9999360.58
Participants: 44
Project status: SIGNED

EurofleetsPlus will facilitate open access to an integrated and advanced research vessel fleet, designed to meet the evolving and challenging needs of the user community. European and international researchers from academia and industry will be able to apply for several access programmes, through a single-entry system. EurofleetsPlus will prioritise support for research on sustainable, clean and healthy oceans, linking with existing ocean observation infrastructures, and support innovation through working closely with industry. The project will enable access to a unique fleet of 27 state-of-the-art research vessels from European and international partners. Through competitive Calls, researchers will be able to access the entire North Atlantic, Mediterranean, Black Sea, North Sea, Baltic Sea, Pacific Southern Ocean and Ross Sea. In addition to ship time, researchers will also have access to new Autonomous Underwater Vehicles and Remotely Operated Vehicles. A unique portable telepresence system will enable remote access by researchers and diverse end users including the public; a first for Europe. In addition to comprehensive transnational activities, the project will undertake joint research activities to meet the evolving challenges of marine research, in particular, deep ocean research and exploration, data management, and virtual access. Multiple networking activities will ensure robust Call processes; wide stakeholder engagement; development of a strategic roadmap and long-term sustainability plan; diverse training and education activities; management of innovation; and widespread dissemination and communication. EurofleetsPlus will facilitate access to unique marine infrastructure, enabling excellent research, increasing ocean literacy, and providing a clear road map for the continued integration and advancement of the European research fleet.

Keywords: research vessels,marine research,telepresence,remote access,deep ocean research,ocean observation,healthy oceans,infrastructure roadmap
Halogen metabolism of brown macroalgae and its biological significance in the context of pathologies - An omics approach (HALOSPATH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-11-23
End date: 2023-01-22
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Macroalgal pathogens are a threat to the sustainable development of macroalgal mariculture and natural populations in marine ecosystems, causing spectacular disease outbreaks and significant losses (10-20% annually). The lack of proper posteriori containment and disease management measures has increased the urgency to study macroalgal pathologies. Nevertheless, the biology of macroalgal pathogens is understudied and limited to their documentation and phylotaxonomy. Elicitor-based short-term studies mimicking pathogen infection complemented with recent transcriptomics and proteomics of Ectocarpus-Eurychasma pathosystem highlighted the induction of haloperoxidases as a generic defense mechanism in brown macroalgae. Nothing is known about the nature of metabolites, in particular halometabolites, involved in macroalgal host-pathogen interactions till date. HALOSPATH intends to elucidate the significance of halogen metabolism in defense and immunity mechanisms of the filamentous brown macroalga Ectocarpus (containing one haloperoxidase gene) and the morphologically complex Laminaria (containing two large multigenic families of bromo- and iodo-peroxidases) against pathologies, using an integrated approach of time-series comparative metabolomics, and RNA-seq transcriptomics. This will generate large metabolomic and transcriptomic datasets, offering unprecedented insights to advance the knowledgebase of disease resistance/infection mechanism in macroalgae, revealing the secrets behind the infective success of these pathogens that could be exploited for resilience of macroalgal ecosystem to pathogens. Potential bioactive halometabolite products will be explored during secondment at MEDINA, envisaging transfer of knowledge across EU. This project will significantly advance the scope of existing research in the host lab and contribute to gender equity in research. I will acquire cutting-edge analytical, molecular skills and expertise to lead my own independent research group.

Keywords: macroalgae,endophytes,disease,metabolomics,transcriptomics
Computational Literary Studies Infrastructure (CLS INFRA)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Integrating activities and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Ireland,Ireland,Austria,Belgium,Serbia,Poland,France,France,Czechia,Netherlands
Call: Integrating Activities for Starting Communities (H2020-INFRAIA-2020-1, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 4999942.5
EU funding (EUR): 4999941.0
Participants: 14
Project status: SIGNED

The CLS INFRA project brings together and further develops institutional, national and regional efforts to build shared and sustainable infrastructure - high-quality data, tools and knowledge needed to undertake literary studies in the digital age. The resulting improvement in provision will benefit researchers by bridging gaps between greater- and lesser-resourced communities in computational literary studies and beyond. It is a particularly opportune moment for this activity, as projects across the literary genres have defined the requirements for such and infrastructure and organised the user community to be ready to use it. The landscape of literary data is currently very heterogenous, with the long and varied tradition of digital libraries meaning that while many resources are available, they are far from standardised in terms of how they are constructed, accessed and the extent to which they are reusable. CLS INFRA deploys strategies to align these diverse resources with each other, with the tools needed to interrogate them, and with a widened base of users able to create knowledge with and from them. It builds interoperability that integrates common and less common standardisation approaches, workflows to help researchers create, access, share, link, analyse, and interpret heterogenous data across languages and sources; and tools for accessing, harmonising and analysing data, all within a robust suite of stable technical approaches and standards. The project is delivered by a geographically balanced, complementary transnational consortium of key local and national infrastructure providers, covering the full range of the projects defined areas for integration and innovation and aligned so as to create a common infrastructural approach for computational literary studies in a maximally efficient and effective manner. In particular the deep integration of both the CLARIN and DARIAH ERICs ensure the project’s long term stability and sustainability.

Keywords: literary studies,computational literary studies,digital humanities,research infrastructure
ICEBREAKER (ICEBREAKER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2016-10-01
End date: 2017-09-30
Duration (months): 12.0
Total project cost (EUR): 149954.0
EU funding (EUR): 149954.0
Participants: 1
Project status: CLOSED

In the ICEBREAKER Proof of Concept (PoC) we will explore the industrial applicability and potential for commercialization of the computational technology developed in the SAFECON Advanced Grant project (www.cimne.com/safecon ) for the study of the navigation of a ship in an iced-sea and the determination of the ice drag of the vessel and the ice-induced resistance on the vessel hull. Up to date a commercial simulation tool including such features for the study of ice-ship interaction situations is simply not available. The ICEBREAKER PoC will help move the SAFECON software technology towards the initial steps of an innovation process leading to a new simulation software for helping naval architects to improve the design of vessels that should be operating efficiently and safely in iced seas. The activities in the ICEBREAKER PoC will include: a) Benchmarking the SAFECON software technology for simulating the navigation of a ship in an iced-sea. b) Establishing the technical viability of application of the software by public and private organizations and companies specialized in ship design, as well as in shipyards and the maritime transport industry. c) Study the possible implementation of the software in existing commercial ship hydrodynamics analysis codes. d) Perform market research for quantifying the potential for the commercial exploitation of the SAFECON software for ice-ship interaction problems. e) Dissemination plan for the software. f) Definition of IPR position. g) Study different exploitation models for the application of the SAFECON software technology for the enhanced design of ships cruising in iced-seas.

Keywords: breakwater ships,ice ship interaction,icy waters,naval engineering,maritime transport
Detection, simulation, modelling and loading of thunderstorm outflows to design wind-safer and cost-efficient structures (THUNDERR)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-09-01
End date: 2021-10-31
Duration (months): 50.0
Total project cost (EUR): 2236161.66
EU funding (EUR): 2236161.66
Participants: 1
Project status: CLOSED

Wind actions are crucial for the safety and cost of structures. The wind climate of Europe and many parts of the world is dominated by synoptic extra-tropical cyclones and mesoscale thunderstorm outflows. Thunderstorms are frequent events causing wind speeds often higher than cyclones. In spite of an impressive amount of research, there is not yet a model for thunderstorm outflows and their actions on structures like that for cyclones. Thus, thunderstorm actions on structures are still determined using the cyclone model developed half a century ago and engineering practice often leads to unsafe or too expensive construction. This happens because the complexity of thunderstorms makes it difficult to develop realistic and simple models. Their short duration and small size make the available data very poor. There is a great gap between research in wind engineering and atmospheric sciences. The realization of an unprecedented wind monitoring network, the role of the PI and his novel vision, a project team leader in wind engineering with interdisciplinary skill in atmospheric sciences, the chance to simulate large-scale thunderstorms in a new unique laboratory, the recent advance in CFD simulations, the success and synergy of previous and on-going projects, and a top host institution represent extraordinary conditions to overcome these shortcomings. THUNDERR is an acronym of THUNDERstorm that points out the ground-breaking Roar of this project. It aims to detect novel thunderstorm measurements, to create a huge dataset of field acquisitions and a new interpretation of their weather scenarios, to conduct unique wind tunnel tests and CFD analyses, to formulate a thunderstorm model that is physically correct and suitable to develop a loading scheme easily transferable to engineering and codification, to radically change the existing wind loading format and the engineering practice, to design safer and cost-efficient structures producing a deep social and economic impact.

Keywords: wind engineering,structural engineering,atmospheric sciences,thunderstorm outflows
Systems Medicine of Mitochondrial Parkinson’s Disease (SysMedPD)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Ireland,Germany,Netherlands,Netherlands,United Kingdom,Luxembourg
Call: Understanding disease: systems medicine (H2020-PHC-2015-two-stage, 2015)
Start date: 2015-12-01
End date: 2020-11-30
Duration (months): 60.0
Total project cost (EUR): 5999990.0
EU funding (EUR): 5999990.0
Participants: 9
Project status: CLOSED

The overall objective of this project is to identify novel drug candidates capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multi-modal phenotypic characterisation of cohorts of monogenic PD patients with overt mitochondrial dysfunction will be used as an anchor for the discovery of two extreme cohorts of idiopathic PD patients: with and without detectable mitochondrial dysfunction. A suite of personalised in vitro, in vivo, and in silico models will be generated using induced pluripotent stem cells (iPSCs) from selected subjects and controls. An industrial quality 3D microfluidic cell culture product, specifically designed for the culture of iPSC-derived dopaminergic neurons, will be developed for use in a morphological and bioanalytical screen for lead compounds reduce mitochondrial dysfunction. By monitoring motor behaviour and in situ striatal neurochemistry at high temporal resolution, the in vivo response to lead compounds will be characterised in humanised mouse models with striatally transplants of iPSC-derived dopaminergic neurons derived from PD patients. Personalised computational models of dopaminergic neuronal metabolism and mitochondrial morphology will be developed. These in silico models will be used to accelerate drug development by prioritising pathways for metabolomic assay optimisation, stratifying idiopathic PD patients by degree of mitochondrial dysfunction, predicting new new targets to reduce mitochondrial dysfunction and mechanistic interpretation in vitro and in vivo experimental results. SysMedPD unites a highly experienced multidisciplinary consortium in an ambitious project to develop and apply a systems biomedicine approach to preclinically identify candidate neuroprotectants, for the estimated 1-2 million people worldwide who suffer from PD with mitochondrial dysfunction.

Keywords: parkinson s disease,mitochondrial dysfunction,personalised medicine,microfluidic cell culture,induced pluripotent stem cells,bioanalytical chemistry,computational modelling,drug screening
Reuse of Olive Mill Wastewater for producing new antioxidant tanning chemicals (TANNOW)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy,Italy
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

Olive Mill Wastewater (OMW) is a highly polluted medium produced in large quantities during olive milling, rich of several polyphenolic compounds, which limit OMW biodegradability in conventional treatment processes. For olive oil producers OMW represents a problem and a disposal cost. Such polyphenols are interesting because of their tanning behavior and high antioxidant strength. The innovation proposed is to transform OMW from waste into raw material with a stabilization process, promoting also highly antioxidant phenols enrichment, to be used in tanning step as medium process in place of water and tannin chemicals, and as reaction medium to produce a new class of antioxidant tanning resin. The goal of TANNOW is to start-up a business initiative, where OMW is collected, transformed and used to produce innovative Cr-free leather articles, or to prevent the oxidation of Cr into carcinogenic Cr VI in Cr-tanned leather. TANNOW intends to answer to the needs of the olive oil producers in terms of valorization of OMW from a waste into a new raw material, and to the needs of the leather users who intends to ban Cr-tanned articles by 2020. The removal of chrome salts in tanning process will have positive impacts on workers and consumers health and on downstream wastewater management. Such problems have certainly an EU dimension, because Europe is the main producer of olive oil and the world leader in leather production. The feasibility assessment will prove the soundness of the business model, confirm evidence of the actual market demand and attractiveness of the products, and describe the minimum operative size of the equipment that covers the initial sales plan, in order to start-up and implement in phase two the production of stabilized OMW, derived tanning resins and Cr-free leather for their commercialization.

Keywords: waste management,olive mill wastewater,renewable raw materials,leather,tanning chemicals,antioxidants