Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Dissecting the regulatory logic of cell fate reprogramming through integrative and single cell genomics (CellKarma)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: Italy
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2024-08-31
Duration (months): 78.0
Total project cost (EUR): 1497250.0
EU funding (EUR): 1497250.0
Participants: 1
Project status: SIGNED

The concept that any cell type, upon delivery of the right “cocktail” of transcription factors, can acquire an identity that otherwise it would never achieve, revolutionized the way we approach the study of developmental biology. In light of this, the discovery of induced pluripotent stem cells (IPSCs) and cell fate conversion approaches stimulated new research directions into human regenerative biology. However, the chance to successfully develop patient-tailored therapies is still very limited because reprogramming technologies are applied without a comprehensive understanding of the molecular processes involved. Here, I propose a multifaceted approach that combines a wide range of cutting-edge integrative genomic strategies to significantly advance our understanding of the regulatory logic driving cell fate decisions during human reprogramming to pluripotency. To this end, I will utilize single cell transcriptomics to isolate reprogramming intermediates, reconstruct their lineage relationships and define transcriptional regulators responsible for the observed transitions (AIM 1). Then, I will dissect the rules by which transcription factors modulate the activity of promoters and enhancer regions during reprogramming transitions, by applying synthetic biology and genome editing approaches (AIM 2). Then, I will adopt an alternative approach to identify reprogramming modulators by the analysis of reprogramming-induced mutagenesis events (AIM 3). Finally, I will explore my findings in multiple primary reprogramming approaches to pluripotency, with the ultimate goal of improving the quality of IPSC derivation (Aim 4). In summary, this project will expose novel determinants and yet unidentified molecular barriers of reprogramming to pluripotency and will be essential to unlock the full potential of reprogramming technologies for shaping cellular identity in vitro and to address pressing challenges of regenerative medicine.

Keywords: cellular reprogramming,single cell genomics
Epithelial/Mesenchymal Cross-talk in response to injury and early tumorigenesis; a spatiotemporal perspective (OESOPHAGEAL FATE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-06-01
End date: 2021-05-31
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Epithelial tissues have evolutionarily adapted to rapidly react to tissue disruption in order to restore the epithelial barrier and ensure survival. The dynamic behaviour of epithelial cells in response to injury represents a decisive mechanism to recover tissue integrity. Following injury, not only cycling but also differentiating epithelial cells are able to revert back, reacquiring stem cell-like behaviour and contributing to tissue regeneration. Although this cellular plasticity is normally a strictly controlled and limited process, if inadequately activated in cells with pre-existing tumour-initiating mutations it will have implications for cancer development. In this proposal, I will investigate the little-known mechanisms governing the dynamic changes in epithelial cell behaviour in the events after tissue injury using the uncomplicated architecture of the oesophagus as a model. The aim is to identify molecular regulators governing cell fate switching following the early wound response, and ultimately, reveal their potential relevance for early epithelial tumour formation. Given the increasing relevance of the mesenchymal compartment both in tissue maintenance and disease, I will particularly focus on the contribution of epithelial-mesenchymal cross-talk in the regulation of epithelial fate changes. To this end, I present an innovative approach that combines precise lineage tracing cell fate data with spatiotemporal single-cell whole transcriptomics. This approach relies on cutting-edge techniques and transgenic animal models widely established in the host laboratory that, when combined, will enable the identification of rules regulating behaviour of epithelial cells with temporal and spatial resolution.

Keywords: epithelial plasticity,epithelial mesenchymal cross talk,wound healing,oesophageal,tumorigenesis,lineage tracing
HEI10-mediated elevations in bread wheat recombination (HEIREC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-04-01
End date: 2019-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The increasing demand for food, in the context of a changing climate and deteriorating environments, will be one of the major challenges facing society in the coming decades. However, as breeding a new crop variety currently takes on average 10 years, the predicted changes in food demand and climate are only several breeding cycles away. Meiotic recombination and crossover is a major tool used in crop breeding when diverse strains are hybridized in order to combine useful traits. Therefore, in the current climate of change, there is an urgent need to reduce the time needed to produce new crop varieties, and meiotic recombination is one target to achieve this. In my ERC Consolidator grant SynthHotSpot, we are investigating the molecular control of meiotic recombination using the model plant Arabidopsis. We have identified the gene HEI10, which encodes a conserved meiotic ubiquitin E3 ligase, as a major regulator of crossover numbers. Importantly, during this work we discovered that HEI10 is highly dosage-sensitive and introduction of additional copies of this gene more than doubled crossovers throughout the Arabidopsis chromosome arms. As HEI10 is conserved between plants, fungi and animals, this may provide a gene target to manipulate crossover numbers in diverse species. In light of the demands on breeding companies to develop new, high yielding crop varieties, HEIREC will fast-track the development of a new platform technology to increase recombination frequency during breeding, via introduction of additional HEI10 copies. Within HEIREC we will generate proof of concept data where we increase HEI10 copy number within bread wheat, in order to increase recombination and thereby accelerate crop improvement. Bread wheat is a major crop globally where recombination level limits strain improvement. Therefore, by increasing recombination frequency during breeding, HEIREC will accelerate the development of new crop varieties and contribute to ensuring food security.

Keywords: meiosis,crossover,recombination,breeding,crops,food security
Advancing Sustainable Circular Bioeconomy in Central and Eastern European countries: BIOEASTsUP (BIOEASTsUP)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable and competitive bio-based industries and supporting the development of a European bio-economy
Action type: Coordination and support actions
Countries involved: Germany,Estonia,Lithuania,Poland,Slovenia,Slovakia,Hungary,Bulgaria,Finland,Croatia,Hungary,Poland,Romania,Slovakia,Slovakia,Poland,Latvia,Latvia,Czechia
Call: Support to the BIOEAST initiative: boosting knowledge and innovation-based bioeconomies (H2020-RUR-2019-1, 2019)
Start date: 2019-10-01
End date: 2023-03-31
Duration (months): 42.0
Total project cost (EUR): 3000000.0
EU funding (EUR): 2999837.5
Participants: 28
Project status: CLOSED

The overall objective of BIOEASTsUP project is to support the BIOEAST initiative and Action Plan for transition of 11 Central and Eastern European (CEE) to bioeconomy. The specific objectives are: SO1: To trigger strategic thinking at governmental level and transnational peer-to-peer development of national circular bioeconomy strategies in BIOEAST countries. SО2: To emphasize the role of multi-actor approach in developing new value chains to advance bioeconomies. SO3: To develop in a multi-stakeholder driven approach a consolidated BIOEAST Strategic Research and Innovation Agenda (SRIA). SO4: To set-up and maintain a macro-regional framework in support of the BIOEAST initiative and the SRIA development and sustainability. SO5: To facilitate evidence-based policy making. SO6: To increase the visibility of the bioeconomy within the quintuple helix in the BIOEAST region. BIOEASTsUP methodology was developed to support a parallel setup: the project structure and the structure of the BIOEAST Initiative. Two work packages focus on the national bioeconomy deployment (WP1, WP2), two are dedicated to the impact at the macro-regional and the EU level (WP3, WP4) whereas dissemination activity complements all the components (WP5). The work plan is as follows: WP 1: Framework for National Bioeconomy Strategies Development WP 2: Capacity building for BIOEAST stakeholders WP 3: Establishing macro-regional structures in support of the BIOEAST initiative WP 4: BIOEAST SRIA development and positioning the macro-regional economies WP 5: Communication, Dissemination and Exploitation WP 6: Project Management and Evaluation BIOEASTsUP has been initiated directly by the BIOEAST Initiative’s ministries. In total 26 ministries support the project. In addition associations, industrial chambers, innovation centres, other research organisations and NGOs have committed to the project. BIOEASTsUP will further engage all stakeholders in the bioeconomy value chain to coordinate efforts to maximize the impact.

Keywords: bioeconomy,circular economy,bioeast
Furthering Improvements in Integrated Mobility Management (I2M), Noise and Vibration, and Energy in Shift2Rail (FINE-2)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: European rail initiative
Action type: Innovation actions
Partnership: Shift2Rail (Art-187)
Countries involved: Austria,Germany,Germany,Germany,Germany,Germany,Germany,Spain,Spain,Italy,Germany,Sweden,Switzerland,Sweden,France,Netherlands,United Kingdom
Call: Integrated mobility management (I2M), Energy and Noise & Vibration (H2020-S2RJU-CFM-2019, 2019)
Start date: 2019-12-01
End date: 2023-09-30
Duration (months): 46.0
Total project cost (EUR): 5023184.98
EU funding (EUR): 3635174.5700000003
Participants: 23
Project status: SIGNED

Formed of three discrete workstreams, the FINE-2 project will investigate means of enabling Integrated Mobility Management (I2M), saving Energy, and reducing inconvenient and disruptive Noise and Vibration (N&V) within the Rail Sector. As a Cross Cutting Activity of the Shift2Rail Programme, FINE-2 will work alongside multiple existing projects to achieve more impactful results through collaboration and shared learning. The I2M workstream will help to enhance the business case for intermodal freight transportation by tackling many of the issues present today, such as accurate ETA, control of hazardous material, and reduced resource waste. I2M will also look at improving Rail Operations through the new forms of data combination and representation. The Energy workstream will develop tools to help understand the energy saving potential, thus Whole Life Cost benefits, of specific enhancements within the industry. It will also optimise tunnel resistance characteristic methodologies, and seek to enhance energy norms to reflect existing state of the art and future developments. Finally the N&V will develop and enhance existing models and simulation tools from across the S2R programme to better understand the source of external noise, whether the train is at standstill or in motion, to help pinpoint the means of reducing it.

Keywords: noise and vibration,energy,integrated mobility management,cross cutting activities,freight,passenger trains
Nano-Enabled Conducting Materials Accelerating Device Applicability (NECOMADA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: Innovation actions
Countries involved: Germany,Germany,Spain,Germany,Spain,Belgium,Belgium,Finland,United Kingdom,Denmark,United Kingdom,United Kingdom
Call: Pilot lines for manufacturing of materials with customized thermal/electrical conductivity properties (H2020-NMBP-PILOTS-2016, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 8101378.75
EU funding (EUR): 6820288.75
Participants: 13
Project status: CLOSED

The project targets the incorporation of advanced functional materials to deliver customised conductive inks and flexible adhesives compatible with high volume manufacturing platforms. Specifically the development of these enabling materials will support high speed roll to roll integration of hybrid and large area electronics to address internet of things opportunities The consortium will integrate materials development with end application requirements in terms of technical performance (thermal/electrical conductivity, processing conditions, materials integrity and adhesion) and unit cost of production to facilitate market adoption. The project will utilise and build on existing CPI pilot facilities (R2R print line) to demonstrate technology integration, manufacturability and produce components for end user evaluation to enable the direct comparison of production techniques. The project delivers a supply chain to support future commercialisation: incorporating materials suppliers of inks and adhesives, supporting RTO in Formulation and nano-particle production, established high fidelity print equipment manufacturers, electronic device manufacturers, established pilot line facilities and potential end users from the apparel, packaging and healthcare sector – relating to the internet of things.

Keywords: conductive adhesives,electrical conductivity,high volume manufacturing,printed electronics
The first high-performance, all-in-one optical sensor technology to monitor the health of our oceans (AquapHOx)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Austria,Germany
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-11-01
End date: 2021-01-31
Duration (months): 27.0
Total project cost (EUR): 1746410.0
EU funding (EUR): 1222487.0
Participants: 2
Project status: CLOSED

AquapHOx is a new optical sensor technology for aqueous environments that measures critical parameters essential to monitor the health of our oceans. Oceans cover more than 70% of the earth surface and are responsible for the basic biogeochemical cycles. Today, CO2 emissions have already led to a dramatic acidification of the oceans. A slight change of the pH value in water has a serious effect on the complete ecosystem and thereby our climate. To get a comprehensive overview of the oceans’ status, marine R&D companies and organisations are urgently looking for technologies to measure under deep-sea conditions i.a. pH values, O2, O2 traces, CO2. In addition, aquaculture is a booming market requiring highly precise measurement of such parameters to monitor water quality and guarantee healthy and environmentally-sustainable farming conditions. Yet, current systems are either non-existent or have very low performance. AquapHOx enables, for the first time, pH measurement under deep-sea conditions, exceeds the state-of-the-art for O2 measurement and allows for the first time to measure several parameters with a single instrument, enabling large-scale, stable, accurate measurements and a reduction of up to 80% of purchasing, maintenance, transport and renting costs. In addition, it is extendable to the measurement of further parameters (CO2, ammonium). By the end of the project, PyroScience will introduce 2 product versions of AquapHOx to the market: one for OEMs and one for end users. The AquapHOx series will be first offered to the marine R&D (especially oceanography) and the aquaculture markets. In a second step, PyroScience will address growth markets of bioprocessing and of water quality control, where further strong market potential has been assessed. Further promising application is expected in medical applications, i.e. blood gas and breath gas analyses. AquapHOx will largely contribute to the PyroScience group’s growth: €28.61M turnover and +52 employees by 2024.

Keywords: optical sensor technology,marine randd,aqueous environments,oxygen,water quality,control,seawater,freshwater,wastewater,bioprocessing,life sciences,blood gas and breath gas,analyses
Photonics for High-Dimensional Quantum Networking (PIQUaNT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 2050758.0
EU funding (EUR): 2050758.0
Participants: 1
Project status: SIGNED

Humanity’s reliance on the rapid and free flow of information cannot be understated. Over the last two decades, control over the spectral, temporal, and spatial structure of light has led to a massive increase in optical data transfer rates via signal multiplexing. For example, the simultaneous encoding of information in 84,236 spatial and frequency channels was recently used for achieving a record 10 Petabit/sec data transmission rate. As quantum technologies mature, so will the needs of a quantum infrastructure that relies on the efficient and noise-robust transfer of information. Precise control over the photonic degrees of freedom (DOFs) of space, time, and frequency offer the potential to enable similar breakthroughs for the fields of quantum communication and networking, and in parallel unlock key functionalities for quantum imaging and sensing with light. PIQUaNT will develop methods for the coherent control and measurement of the high-dimensional position-momentum and time-frequency DOFs of a photon, and drive forward the creation of techniques for combating sources of noise that inhibit the long-distance transfer of multi-mode quantum information. PIQUaNT will in turn apply these techniques in demonstrations of noise-resilient, high-capacity entanglement distribution in multiple photonic DOFs over commercially available multi-mode and multi-core fibres. Through the realisation of a prototype entanglement-based high-dimensional quantum communications network, PIQUaNT will serve as a blueprint for the future development of noise-robust quantum information networks that saturate the information carrying capacity of a photon.

Keywords: entanglement,spatial modes,temporal modes,quantum communication
The Shrinking Space for Civil Society in Europe (CIVILSPACE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Institutions, Governance and Legal Systems
Panel description: Political science, international relations, law
Countries involved: Germany,Italy,Hungary
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2022-03-01
End date: 2027-02-28
Duration (months): 60.0
Total project cost (EUR): 1912100.0
EU funding (EUR): 1616726.25
Participants: 3
Project status: SIGNED

Long considered a problem of ‘third countries’, concerns about ‘shrinking civil society space’ have moved to the heart of the European Union: confronted with the challenges of domestic terrorism, financial crisis and populist government numerous member states have passed legislation constraining civil society organizations (CSOs) (e.g. EC 2018; CoE 2018; FRA 2018). Indeed, since the early 2000s, government control over and repression of civil society increased in 2/3rds of member states. This project proposes the first theoretization and comprehensive assessment of the drivers and repercussions of the ‘shrinking of legal space’ for CSOs in the EU. It asks: How and why have EU member states altered the legal environments of CSOs over the last two decades? How do legal differences shape CSO activities central to assuring legal and political equality within organized civil society? The theoretical framework on the drivers and organizational repercussions of ‘legally defined’ civil society space will be examined through a sophisticated, interdisciplinary, mixed-methods design. Work package 1 examines the impact on CSO law of major challenges (domestic terrorism, financial crises, populist governments) as mediated by member states’ historically grown dispositions towards or against restricting civil society. This is done through the first comprehensive statistical assessment of the changing legal restrictiveness in both framework legislation and ‘organization-specific legal regimes’ tailored to six CSO types (e.g. unions, religious, pro-immigrant CSOs) in 12 EU member states (2000-22). On that basis, Work package 2 examines in a subset of six countries through qualitative case studies how public authorities implement CSO legislation and through large-scale CSO surveys with an in-built experiment CSOs’ political engagement and their resistance against government through public contestation and legal action considering law-conforming and chilling effects of regulation.

Keywords: civil society restrictions,cross national research,legislative reform,organizational response