Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mid Infrared SpectrometerS by an Innovative Optical iNterferometer (MISSION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-06-01
End date: 2016-11-30
Duration (months): 18.0
Total project cost (EUR): 149625.0
EU funding (EUR): 149625.0
Participants: 1
Project status: CLOSED

The MISSION projects aims at bringing to the market a revolutionary concept of mid-infrared (MIR) interferometer, for a new generation of compact, low-cost, rugged spectrometers. Many applications of chemistry, materials science and life sciences require analysis and identification of substances based on their vibrational absorption spectra in the MIR. Time domain vibrational spectroscopy techniques such as FTIR and 2DIR are based on the use of an optical Michelson interferometer, producing two identical phase-shifted replicas of the input beam. Phase determination is technically very challenging and requires tracking with an auxiliary laser beam and in some cases the use of active stabilization approaches, with feedback control on the interferometer arms, greatly increasing device complexity. We have recently introduced a new optical interferometer, called TWINS, which exploits material birefringence to impose highly controllable delays. TWINS has the advantages of being inherently phase stable, compact, rugged, highly reproducible and potentially low cost. The TWINS concept, for which a patent has been filed, was successfully demonstrated in the visible and the MIR spectral ranges. It is the goal of the MISSION project to unleash the innovation potential of TWINS, by developing, technically validating and bringing to the market a TWINS-based MIR interferometer, paving the way to a new generation of compact and low-cost analytical instruments for a wide range of applications. We have identified a suitable material with broad MIR transparency and huge birefringence: calomel. The MISSION project aims at: i) building a TWINS device based on calomel; ii) demonstrating its application to MIR spectroscopy; and iii) turning it into a commercial product, to be sold either as stand-alone device or as part of a spectroscopic instrument. We expect that TWINS will significantly reduce the cost of MIR interferometers, thus widely broadening their application portfolio.

Keywords: vibrational spectroscopy,mid infrared,fourier transform infrared spectroscopy,michelson interferometer,birefringence
Economic Policy in Complex Environments (EPOC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Spain,Italy,Italy,Germany,France,Netherlands,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2020, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 3982061.52
EU funding (EUR): 3982061.52
Participants: 7
Project status: SIGNED

Many of the main current economic and societal challenges in Europe are characterised by complex dynamic patterns stemming from path dependency, irreversibility, systemic risk and (local) interaction of heterogeneous agents. Examples in this respect are the search for appropriate policies to mitigate climate change, to foster a transition to a low-carbon economy, or to govern the development, diffusion and economic implications of new technologies. Designing sound economic policy in such domains is challenging and should be informed by empirical analyses and modelling frameworks that are suitable for capturing the complexity of the (economic) environment. The Innovative Training Network EPOC aims at advancing the state-of-the-art and the applicability of computationally intensive methods for decision and policy analysis and at using these methods in the domains of climate change and innovation. This agenda will be pursued by combining an interdisciplinary research agenda with an innovative European joint doctoral training programme. Early Stage Researchers will gain expertise and skills in data science, network theory, agent-based simulation, and economic modelling, with focus on climate change and innovation, and will apply these skills in their individual research projects. The academic training will be complemented by Transferable Skills Training Measures, Inter-Sectoral Training Measures, provided by non-academic partners, and Career Development Training. Interaction with stakeholders, policy makers and the general public will play an important role in pursuing the EPOC agenda and disseminating the results. The EPOC consortium consists of seven leading European universities and ten partner organisations. Each Early Stage Researcher will be hosted by two universities, will have a secondment with a partner organisation, and will graduate with a double degree.

Keywords: agent based computational economics,network theory,data science,economic policy,innovation
RE-SAMPLE (RE-SAMPLE)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Estonia,Italy,Belgium,Greece,Netherlands
Call: Use of Real-World Data to advance research on the management of complex chronic conditions (H2020-SC1-2020-Single-Stage-RTD, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 5960795.0
EU funding (EUR): 5960795.0
Participants: 11
Project status: SIGNED

Multi-morbid complex chronic conditions (CCCs) are highly prevalent in patients with Chronic Obstructive Pulmonary Disease (COPD). As they have common risk factors and overlapping symptoms, this easily leads to delay of appropriate treatment. Timely and preventive care is essential, as exacerbations of COPD and CCCs are detrimental to patient, health and social outcomes. RE-SAMPLE will take a giant leap in the field of CCC disease management building upon and going beyond existing initiatives, towards evidence-based, inclusive, preventive care and targeted treatment, enabling to “treat a person, not the disease(s)”. RE-SAMPLE will create a knowledge base of multimodal data from health records, clinical studies, expert and patient knowledge and guidelines, and extend this with state-of-the-art Real World Data collection. Predictive modelling through privacy-preserving Artificial Intelligence (AI), will increase the understanding of CCCs including the interdependence of multi-morbidities, and evidence in effective interventions for CCC disease management. The inclusive design and citizen science approach, provides us with credible and accepted RWD tools and a patient-centred eHealth “companionship programme”. GDPR-compliance is carefully integrated from the beginning, and our platform allows for a strong advancement in secure algorithms using multi-party computation. Our AI approach enables statistical validation following clinical standards and useful explanations to build up clinical evidence and trust by the users. As such RE-SAMPLE will act upon the need for diversified, personalized care to alleviate the overall societal and economic burden of these CCCs. The RE-SAMPLE project significantly impact towards this direction not only through the development of the platform and companionship programme, but also through its implementation throughout Europe, enabling and guiding healthcare organizations its uptake in the privacy-sensitive domain of healthcare.

Keywords: gdpr,secure data management,privacy protection,federated learning,ehealth,copd,decision support,chronic disease management,multi morbidity patient centred care,machine learning
Demonstration of a 1-MW wave energy converter integrated in an offshore wind turbine farm (UPWAVE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Innovation actions
Countries involved: Spain,Belgium,Belgium,Belgium,France,France,Denmark,United Kingdom,Denmark
Call: Demonstration of renewable electricity and heating/cooling technologies (H2020-LCE-2015-2, 2015)
Start date: 2016-02-01
End date: 2021-01-31
Duration (months): 60.0
Total project cost (EUR): 28866787.5
EU funding (EUR): 20722489.880000003
Participants: 9
Project status: TERMINATED

The aim is to develop and install a pre-commercial wave energy converter (WEC) of 1MW power, the WAVESTAR C6-1000 device, with main targets the device industrialization and the demonstration of wind and wave energy applications. The utility company Parkwind, which develops, builds and operates wind farms in the North Sea, is committed to the achievement of WAVESTAR’s next development stage. Parkwind provides the installation site with grid connection for the first full-scale WAVESTAR WEC, located within a Belgian offshore wind farm. The UPWAVE project consortium has been developed through the establishment of strong synergies and partnerships, by bringing together key European industrial players and European universities represented by wave energy experts whose overall objectives focus on: 1) Reduction of the device’s cost by introducing new design, components and materials. Cost optimization is achieved through new methods on deployment, installation, operation and maintenance. 2) Improvement of the energy efficiency by developing a more advanced Power Take Off based on a second generation digital hydraulic system and innovative control strategy. 3) Integration of wave energy converters in wind farms by considering the interaction between wave and wind devices in terms of operation, cost reduction and maximization of environmental benefits. Public research programs, industrial cooperation and technology transfer from the offshore industry (offshore wind, oil and gas) ensure the development of manufacturing processes, automation and optimisation of the WAVESTAR C6-1000 WEC. New certificates and standards will be made available for the wave energy industry. After the completion of the UPWAVE project, the cost of wave energy will be significantly reduced to a level in line with the cost of offshore wind energy (around 15 c€/kWh). The WAVESTAR C6-1000 demonstrator device will lead to a commercial WEC and a hybrid renewable energy device (wind and wave).

Keywords: wave energy
Economy of Pre-Roman Adriatic Communities: amphora production and trade patterns in a changing world (EPRAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The proposed EPRAC project focuses on the economy of the Adriatic region during the Pre-Roman periods from time of establishment of Greek settlements in 4th c. BC to consolidation of Roman power toward the end of the last millennium BC. The proposed project focuses on the under-studied eastern Adriatic region and seeks to characterise the nature of trade and interaction between indigenous communities as well as with the Aegean and nearby Italy from 4th till the end of the 2nd c. BC. The objectives of the proposed research project are fourfold. Firstly, to characterize in detail the nature of amphorae production at the sites of Issa and Pharos on the Dalmatian Islands, in southern Croatia, for the first time. This will be compared to amphorae from consumption sites in order to understand the trade patterns and circulation of liquid commodities transported via amphorae. By mapping the scale and direction of movement of amphorae and their goods from these and other more distant sites, the project with shed light on important economic and social developments taking place in this region from the 4th till the 1st c. BC. Key questions in this area include the influence of Issa and Pharos, the extent of participation of Adriatic communities within regional networks and finally, the its degree of contact with the wider Mediterranean. Proposed project will be carried out in seven research activities within four working packages, that will include archaeological and analytical methods in studying amphorae. The project will involve a detailed programme of research and training, theoretical during the attendance of the courses at Institute of Archaeology at UCL and practical hands-on-training in the laboratory within UCL’s Ceramic Technology Research Network. Together with data management and dissemination activities, this will greatly enhance the career prospects of the researcher.

Keywords: adriatic,pre roman period,amphorae,archaeometry,production,trade
Exploring the non-genetic (i.e. ePIgenetic) mechanisms that contribute to therapy Escape in melanoma (EscaPI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

Resistance to anticancer drugs, which often develops from a heterogeneous pool of drug-tolerant cells known as minimal residual disease (MRD), is thought to mainly occur through acquisition of genetic alterations. Emerging evidence indicates that drug resistance may also be acquired in absence of a genetic cause. It remains unclear, however, whether genetic versus non-genetic mechanisms of resistance are selected in a stochastic manner, and what are the epigenomics mechanisms underlying the transition from drug-tolerance to resistance. This project aims at identifying the drug-tolerant subpopulation(s) that drive non-genetic resistance by performing lineage tracing and depletion experiments in pre-clinical models. Taking advantage of up-to-date technologies combining in vivo barcoding and single-cell multi-omics approaches, this project aims to provide a dynamic and integrated view of the evolution of epigenomic profiles -at single-cell resolution- before, during and after acquisition of drug resistance phenotypes in a in vivo clinically-relevant context. A third objective of this proposal is to search for predictive biomarkers of non-genetic resistance and to assess the percentage of melanoma patients that undergo non-genetic resistance through combination of multiplexed staining and targeted DNA sequencing. The success of this project is ensured by my personal background in epigenetics and related data computational analysis, the achievements of the JCM lab in melanoma epigenetic reprogramming and the close collaborations with experts in single-cell multi-omics fields. I anticipate that my involvement in this project will broaden my skills and knowledge and help me become a high-qualified European independent scientist.

Keywords: non genetic mechanisms of resistance to cancer treatment,cancer,melanoma,single cell multi omics,epigenomics,enhancers,lineage tracing,barcoding,biomarkers
An Icelander among the Gaels: A Study of Grímur Thorkelin (1752-1829) and his Gaelic Manuscripts (Thorkelin)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-08-01
End date: 2022-07-31
Duration (months): 24.0
Total project cost (EUR): 207312.0
EU funding (EUR): 207312.0
Participants: 1
Project status: CLOSED

This project focuses on the Icelandic-Danish scholar Grímur Thorkelin (1752-1829) and his contact with the literature and culture of the Gaelic-speaking world in the late-eighteenth century. Commissioned by the King of Denmark to travel through Britain and Ireland in search of historical material relating to the history of Scandinavia, Thorkelin took a particular interest in the Gaelic culture of Ireland, Scotland and the Isle of Man. This contact is primarily evidenced by his substantial collection of Gaelic-language manuscripts, both medieval and early modern, now preserved in Copenhagen's Royal Library. This project, in the first instance, seeks to document and catalogue these manuscripts and to open their contents up to further study. It also addresses a number of questions raised by the collection. These include the dynamic between manuscript and print in Gaelic and in Thorkelin's native Icelandic. Thorkelin's role as as international patron of scribes and collector of manuscripts will also be addressed. As an historian, Thorkelin's framing of Gaelic history, and indeed his framing of Icelandic and Scandinavian history in Britain and Ireland, exerted considerable influence on the eighteenth-century conceptions of ethnic and cultural identity, this will be addressed in relation to Scotland in particular. This project therefore takes Thorkelin and his important collection of Gaelic manuscripts, using them as a prism though which to examine questions relating to contemporary eighteenth-century concerns, most especially around literary and scribal culture. Home to experts on manuscript studies, textual philology and Icelandic Studies, the Arnamagnæan Institute, within the Department of Nordic Studies and Linguistics at UCPH is the only place where I would want to carry out this research which will push the intellectual, national and disciplinary boundaries of the current 'state of the art' of Gaelic manuscript studies.

Keywords: gaelic,irish,scottish,manx,manuscripts,celtic studies,iceland,scribes,palaeography,republic of letters,scandinavian studies,print,books
A Novel Eco-Friendly, dually Efficient and Resistance-free Treatment of vaginITIs (NEFERTITI)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Germany,Norway,Sweden,Sweden,Denmark,United Kingdom,United Kingdom
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2019)
Start date: 2020-01-01
End date: 2022-06-30
Duration (months): 30.0
Total project cost (EUR): 4629606.95
EU funding (EUR): 2991774.0
Participants: 7
Project status: CLOSED

Bacterial vaginosis (BV) and vulvovaginal candidiasis (VCC) are common vaginal infections caused by Gardnerella and other anaerobic bacteria. or by Candida fungi. The infection can occur once - the acute form - or recur repeatedly over the course of a year. About 68m women in Europe and the US are infected each year. They cause intense physical discomfort, adversely affects quality of life and have heavy socioeconomic costs. Many women opt to self-treat with non-prescription over-the-counter antifungals which fail because the causative microorganism has not been properly identified. Antibiotics for BV are encountering increasing levels of drug resistance. Combination of misdiagnosis, misuse, non-compliance, overconsumption leads to low efficacy and high recurrence rates for both VVC and BV. NEFERTITI FTI will demonstrate in clinical trials a pessary based on glucono-δ-lactone –trademarked as pHyph - as a highly effective cure for acute and recurrent BV and VVC, and as a far better alternative to antibiotics or antifungals. pHyph restores the vaginal mucosa to pH4 and disrupts Candida biofilms, promotes the proliferation of natural and protective aerobic lactobacilli, and displaces Gardnerella and other anaerobic pathogenic bacteria. pHyph is a single solution for both pathogens and infections, and with both curative and protective effects, and does not trigger drug resistance in the microbiome. These features are unmatched by any other product on the market – whether as over the counter or prescribed. NEFERTITI FTI will also develop a post-project business plan for the rapid scale up of production and commercialisation of pHyph in Europe in 2022 as an over-the-counter product into a market for BV and VVC treatments worth €1.7bn in 2022 and will be commercialised through a major drug distributor. The same plan will also mark the regulatory steps and commercial partners needed for pHyph to reach the US market in 2024.

Keywords: candida,gardnerella,vaginal thrush,vaginal bacteriosis,recurrence,self treatment,antimicrobial resistance,vaginal microflora,pessary,lactobacilli,over the counter medicines
Active Monitoring of Cancer As An Alternative To Surgery (CAST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Italy,Germany,Germany,Sweden,France,France,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,Portugal,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2019, 2019)
Start date: 2019-11-01
End date: 2024-10-31
Duration (months): 60.0
Total project cost (EUR): 4102371.36
EU funding (EUR): 4102371.36
Participants: 14
Project status: SIGNED

When a patient is discovered to have cancer, one of the primary goals is to have the tumour removed by surgery. Although this provides excellent oncological control, it is associated with morbidity and functional problems in cancer survivors. Recent studies have shown that the immediacy to perform a resection does not always lead to improved clinical outcome. Furthermore, cancer surgery can often lead to complications where the quality of life for the patient is compromised by toxic side effects and /or damage to nerves, organs or healthy tissues. A number of recent clinical trials in the field of cancer surgery have advocated the concept of watch and wait, watchful waiting, active monitoring or surveillance, which are terms used to describe a monitoring strategy for cancer. The concept may be antithetical but the functional advantage of these alternatives is clear even though there is some concern about the risk. Though the evidence is still weak, current studies suggest that with adequate selection and follow-up, this oncological risk is small. A major consideration for clinicians is now to maintain quality of life for all patients. Our objective in this proposal is to implement novel approaches so that cancer surgery can be avoided, where we aim to (a) develop new monitoring technologies from industry so that the surveillance window can be increased to allow for better treatment options over time and to avoid surgery, (b) develop new ‘watch and wait’ strategies in order to study the behaviour of the cancer so that any risks to the patient can be minimised leading to a better clinical outcome and (c) train a new generation of preclinical and clinical scientists to be able to implement this new concept as standard of care and to maximise the benefits of an active monitoring policy.

Keywords: tool development,physical sciences,rectal cancer,active monitoring,surveillance,imaging,watchandwait,diagnostics