Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative espresso machine with new water heating and boiler design to improve efficiency and coffee quality (ESSENCE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Italy,Italy
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-05-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

While it may sound strange considering how often coffee is consumed around the world, current professional espresso machines on the market are highly energy inefficient and struggle to consistently achieve and maintain the desired coffee taste quality that people in the industry refer to as “the god shot”. Realizing this market opportunity, an engineering automation company, Eurek SRL, and coffee machine manufacturer, 8B, have partnered to design a new machine that helps bars, restaurants and coffee shops save 50% of their electricity costs while also ensuring customers are served a delicious cup of coffee at any time of day. There have been significant improvements in control technologies that operate coffee machines but the basic internal construction and process of making espresso has changed very little. A coffee machine utilized in a commercial environment must be left switched on 24 hours a day to ensure that the hot water temperature is maintained. This leads to electricity costs that can exceed €7,000 per year. Our innovative design utilizes a modular approach that takes advantage of heating exchange technology to half electricity costs while also ensuring a premium quality coffee brew. New coffee machine designs have so far been unable to achieve this combination. Our new technology therefore has the potential to completely revolutionize the Espresso Coffee Machine industry, which is worth approximately €536 million in Europe alone with over 180,000 espresso machines sold annually. We expect our machine to generate revenues of €8 million by 2022, resulting in profits of €3.35 million that will be split between our two companies.

Keywords: professional coffee machine,espresso,boiler,heat exchanger,quality,energy,efficiency,inteliigent control
Diverging Destinies: Introducing the Role of Social Environment and Genetic Sensitivity in the Effects of Family Instability (DIVERGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United States,Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2019-06-30
Duration (months): 36.0
Total project cost (EUR): 278227.8
EU funding (EUR): 278227.8
Participants: 2
Project status: CLOSED

Today a substantial share of children experience their parents to separate or divorce, to re-partner with someone new, and potentially have children with this new partner. Whereas we know that such family instability has detrimental consequences for children’s behavior and mental health, it remains unclear the degree to which these negative effects are unevenly distributed. In order to disentangle this question, this project investigates the role of social environment and genetic sensitivity in the effects of family instability from a cross-disciplinary perspective. The project uses new and unique data and combines insights from the social and the developmental sciences in order to advance knowledge on three connected issues: 1. Do negative effects of family instability vary for children born into different family structures, and among children experiencing multiple transitions in family structure during childhood? 2. Are negative effects family instability augmented among children with fewer resources available in their social environment? 3. Are negative effects of family instability concentrated among children with greater genetic sensitivity? It is important to improve our understanding of heterogeneity in effects of family instability because it allows us to more effectively address barriers to children’s’ development and families’ social mobility. The results from this project will help explain why some children overcome the experience of social disadvantage while others don’t. Thereby this project helps to better tailor interventions and programs serving children and families, and thus reduce children’s negative outcomes.

Keywords: family instability,child health,social environment,genetic sensitivity
Postsecular Conflicts and the role of Russian Orthodoxy in the transnational alliances of moral conservative traditionalists (POSEC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Austria,Sweden
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2022-04-30
Duration (months): 72.0
Total project cost (EUR): 1499260.0
EU funding (EUR): 1368010.0
Participants: 2
Project status: CLOSED

The POSEC project proposes the study of a hitherto under-researched phenomenon in the field of religion and politics: the rise of traditionalists, i.e. religious actors who rely on the conservative religious and political establishment in their respective home-countries, co-opt political and civil society actors, and forge transnational alliances, thereby inaugurating a new kind of religious politics which has not yet been studied and theorized in depth. The project will explore the agenda and transnational networks of traditionalist moral conservative actors from the perspective of the Russian Orthodox Church and its connections with the Russian political establishment on the grounds that it is necessary to understand the role and the resources of Russian politics and Orthodox religion in order to assess correctly the scope of this “moralist international” and the challenge it poses to liberal democracy. The research will analyse traditionalist actors and their ideas with regard to the three main areas where religious-moral conflicts emerge – religious symbols & free speech, sexuality & gender, and bioethics & biotechnology – and across four international institutional settings – the United Nations Human Rights Council, the Council of Europe, the European Court of Human Rights, and forums of inter-religious dialogue like the World Council of Churches. Adopting a contextualized political theory approach, the project will develop on the basis of the empirical and theoretical insights drawn from this case-study a reflexive political pluralist model of moral conflicts. This model offers an innovative extension to political liberalism inasmuch as it assesses within the political liberal framework the new reality of majoritarian, transnational traditionalist politics.

Keywords: political theory,political liberalism,religion,traditionalism,moral conservatism,conflict,russian orthodox church
Enacting heritage: The aesthetic dynamics of cultural transmission (EnAct)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Aesthetic behaviours and expressive activities carry out a crucial role in human cultural evolution. Aesthetic cognition is important for intersubjective attunement already in early childhood, and attends to cultural emergence and transmission of ideas, practices and norms. However, anthropological scholars haven't ever investigated the cognitive dynamics whereby aesthetic behaviours shape the symbolic processes of constitution and re-enactment of cultural heritage. The proposed research project seeks to address this lacuna by dealing with key issues relating to the role of aesthetic behaviours in cultural transmission. The study focuses on how aesthetic and expressive elements are mobilized in the course of social interaction creatively transforming and communicating knowledge. The originality of the proposed approach lies in the interdisciplinary methodology that has not been used in previous studies of the subject matter. For the first time, a naturalistic and cross-cultural model of aesthetic behaviour will be applied to the context of cultural evolution. Existing naturalistic studies of aesthetics are characterized by a reductionist approach, whereas research on cultural transmission suffers due to the divide between cultural and evolutionary perspectives. This project aims to overcome the traditional opposition of “evolutionary psychology versus ethnography” through an interdisciplinary study of the multimodal, expressive, symbolic, and non-verbal practices whereby human beings collectively perform and share knowledge. The principal result of the project will be the first systematic and comparative analysis of aesthetic behaviours as operative components of cultural transmission. This result will be of interest to a broad scientific audience and will enhance several branches of European research and education, including aesthetics, cultural evolution, anthropology of art, and cultural heritage, by combining research methods derived from different disciplines.

Keywords: aesthetics,cultural transmission,cognitive anthropology,comparative anthropology
Live, In vivo Visualisation of liver Regeneration in Zebrafish After Photoablation of hepatocytes (LIVERZAP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

The specialised tissue architecture of the liver is crucially important for its essential metabolic functions in the body. The liver has the unique regenerative capacity to restore lost architecture when damaged. However, this remodelling process is compromised in chronic liver disease by scarring and cirrhosis. Often the only treatment is organ transplantation, thus the development of novel therapies is of vital importance. The necessary understanding of the dynamic cell rearrangement driving restoration of liver architecture has been limited by temporally static histological analyses of fixed regenerating tissue. Real-time monitoring of the mammalian liver is hindered by tissue opacity and deep organ position, whereas the surface location of the zebrafish liver and larval transparency makes this species uniquely suited for live, in vivo imaging of regeneration. LIVERZAP will generate a detailed map of the different cell behaviours driving restoration of liver architecture by pioneering real-time, in vivo imaging of regeneration in zebrafish. This will be achieved by: i) generating a novel, photoactivatable method for rapid hepatocyte ablation and ii) developing a deep tissue, 2-photon microscopy live imaging protocol. The molecular factors controlling the identified cell behaviours will be screened for using SILAC-based proteomics. To realise LIVERZAP, expertise in liver research, deep tissue microscopy and proteomics within the host environment will be combined with the fellow’s live imaging experience. LIVERZAP will generate excellent new tools for the regeneration community and greatly enhance the fellow’s competencies in specialised techniques, including cutting-edge microscopy systems and optogenetics. The outcomes of LIVERZAP will produce essential insights into the cellular and molecular mechanisms driving restoration of liver architecture following injury, providing a platform for the long-term development of therapies for human liver pathologies.

Keywords: liver,regeneration,live imaging,zebrafish,tissue architecture,cell ablation,injury,optogenetics,cell behaviours,morphogenesis
PROgrade metamorphism MOdeling: a new petrochronological and compuTING framework (PROMOTING)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-06-01
End date: 2025-11-30
Duration (months): 66.0
Total project cost (EUR): 1993125.0
EU funding (EUR): 1993125.0
Participants: 1
Project status: SIGNED

Prograde metamorphism produces large amounts of fluids that have an important role for earthquake generation, arc magmatism, the growth of continental crust and for global geochemical cycles. Despite recent efforts, it remains challenging to recognize and quantify fluid fluxes in natural rocks and to model fluid pathways. The existing petrological modeling techniques are all based on the thermodynamic analysis of single rock types and neglect the chemical changes caused by fluid expulsion and the possible interactions with other rocks. The next frontier in metamorphic petrology is therefore to move our modeling capabilities from an isolated single rock system to an open and multi rock system, in which fluids can flow in, react and flow out. This concept introduces several challenges from the quantification of fluid-rock interactions in natural samples to the integration of aqueous thermodynamics and fluid dynamics in the petrological models. Based on the developments of high-resolution techniques such as quantitative compositional mapping, I have demonstrated that the petrological models can be inverted to quantify prograde metamorphism based on preserved mineral relics that partially re-equilibrated in the presence of fluids. The primary objective of PROMOTING is to develop a brand-new framework for petrological modeling of fluid-rock interactions in different, coupled rock types during prograde metamorphism. The models will be calibrated on two key tectonic settings that shaped Earth: subduction of oceanic crust and differentiation of the continental crust. A cutting-edge petrochronological strategy is required to identify at which conditions and when fluid-rock interactions occurred in natural rocks. The outcomes of this project will not only form the basis for a new generation of models integrating element mobility from rock scale to crustal sections, but they will also bring new constraints to test the validity of the most advanced subduction models.

Keywords: petrochronology,petrological modeling,aqueous thermodynamics,fluid dynamics
Nanomechanical intervention of bacterial mechanotransduction (NIOBMT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-08-01
End date: 2023-07-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Mechanical force is a ubiquitous perturbation that operates at all levels of life, from single molecules to organs. At the tissue level, cells are constantly exposed to forces exerted by their surrounding environment—body fluids, neighboring cells, or the extracellular matrix. The process by which cells sense and convert physical stimuli into a biochemical signal is known as mechanotransduction. When mechanical forces reach the nucleus, they can activate several force-induced transcriptional pathways that control cell functionality. The failure of these pathways has been linked to several human pathologies, such as cancer. While most of our knowledge in mechanobiology is focused on mammalian cells, comparatively little is known on how prokaryotes detect, interpret, and generate a response to physical inputs. Understanding how bacteria sense mechanical forces and how these signals are integrated to promote colonization, biofilm formation, or virulence development is crucial to develop therapeutic strategies that target the pathogenesis onset. Here we propose a cross-scale approach that first employs single-molecule force spectroscopy techniques to study in vitro the dynamics under force of PilY1 —from the Gram-negative opportunistic pathogen Pseudomonas aeruginosa— and how antibody binding affects its mechanical stability. Our goal is to implement a molecular-based strategy that disrupts the PilY-triggered mechanotransduction pathway, which we will probe at the cellular level. Using a combination of optical microscopy and single-cell mechanical techniques, we will monitor in vivo the downstream events that lead to the expression of genes that promote virulence after PilY1 mechanical stimulation in the absence and presence of antibodies that disrupt the activity of this protein.

Keywords: bacterial mechanotransduction,mechanopharmacology and mechanomedicine
HPC for Energy (HPC4E)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Spain,France,France,United Kingdom,United Kingdom,United Kingdom
Call: High Performance Computing (HPC) (H2020-EUB-2015, 2015)
Start date: 2015-12-01
End date: 2017-11-30
Duration (months): 24.0
Total project cost (EUR): 1998176.25
EU funding (EUR): 1998176.25
Participants: 9
Project status: CLOSED

This project aims to apply the new exascale HPC techniques to energy industry simulations, customizing them, and going beyond the state-of-the-art in the required HPC exascale simulations for different energy sources: wind energy production and design, efficient combustion systems for biomass-derived fuels (biogas), and exploration geophysics for hydrocarbon reservoirs. For wind energy industry HPC is a must. The competitiveness of wind farms can be guaranteed only with accurate wind resource assessment, farm design and short-term micro-scale wind simulations to forecast the daily power production. The use of CFD LES models to analyse atmospheric flow in a wind farm capturing turbine wakes and array effects requires exascale HPC systems. Biogas, i.e. biomass-derived fuels by anaerobic digestion of organic wastes, is attractive because of its wide availability, renewability and reduction of CO2 emissions, contribution to diversification of energy supply, rural development, and it does not compete with feed and food feedstock. However, its use in practical systems is still limited since the complex fuel composition might lead to unpredictable combustion performance and instabilities in industrial combustors. The next generation of exascale HPC systems will be able to run combustion simulations in parameter regimes relevant to industrial applications using alternative fuels, which is required to design efficient furnaces, engines, clean burning vehicles and power plants. One of the main HPC consumers is the oil & gas (O&G) industry. The computational requirements arising from full wave-form modelling and inversion of seismic and electromagnetic data is ensuring that the O&G industry will be an early adopter of exascale computing technologies. By taking into account the complete physics of waves in the subsurface, imaging tools are able to reveal information about the Earth’s interior with unprecedented quality.

Keywords: wind energy,biomass derived fuels,exploration geophysics
Portable photonic miniaturised smart system for on-the-spot food quality sensing (PhasmaFOOD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Greece,Serbia,Greece,Belgium,Netherlands,Luxembourg
Call: SSI - Smart System Integration (H2020-ICT-2016-1, 2016)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 3095825.0
EU funding (EUR): 3095825.0
Participants: 10
Project status: CLOSED

The main objective of the project is to design and implement a parameterized, knowledge-based, multi-target food sensitive mini-portable system, with heterogeneous micro-scale photonics for on-the-spot food quality sensing and shelf-life prediction. In particular, the miniaturized smart integrated system will be able to detect food hazards, spoilage (incl. early sign of spoilage) and food fraud through the combined bio-chemical data analysis and additionally will be able to perform food components/additives analysis, food identification and prediction of food shelf-life. The following use case will be addressed during the project: Use case 1: Detection of mycotoxins in various grains and nuts. Aflatoxins detection. A simple, convenient ultraviolet test makes it possible to detect the possible presence of aflatoxin. Use case 2: Detection of early sign of spoilage and spoilage in fruits, vegetables, meat, fish: combined with estimation on product expiration date. Use case 3: Detection of food fraud: Adulteration of alcoholic beverages, oil, milk and meat. 3 sensor devices will be integrated in the miniaturised smart sensor node: i) a MEMS-based near IR spectrometer (950-1900 nm), ii) a UV-VIS spectrometer (450-900 nm) and iii) a micro-camera. Moreover 3 light sources will also be integrated to support the sensing functionality: i) UV-LED, ii) white LED and iii) a miniaturised IR emitter. Smart signal processing of the spectrum images will be performed by an advanced microcontroller, integrated in the sensing device. The data will be communicated to a smartphone device, where the spectroscopy analysis will take place with the help of a cloud-base application connected to a reference database. Advanced detection algorithms will be deployed both in the level of cloud and the smartphone application. PhasmaFOOD system will enable common consumers for on the spot food quality sensing and shelf-life prediction.

Keywords: smart sensing,internet of things,food adulteration,food hazards,near infrared spectroscopy,visible spectroscopy,image analysis,cloud based service,micro scale photonics