Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Towards enhanced coordination of disaster risk management and governance through a holistic framework for multi-level interaction and communication (TOGETHER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Disaster-Resilient Society for Europe
Action type: Research and Innovation actions
Countries involved: Norway,United Kingdom,Greece,Belgium,Germany,Spain,Italy,Türkiye,France,Netherlands,Portugal
Call: Open Topic (HORIZON-CL3-2024-DRS-01, 2024)
Start date: 2025-11-01
End date: 2028-10-31
Duration (months): 36.0
Total project cost (EUR): 2999962.5
EU funding (EUR): 2999962.5
Participants: 20
Project status: SIGNED

The midterm review of the Sendai Framework highlights persistent challenges in disaster risk reduction (DRR), particularly the lack of coordination between disaster risk agencies, sectoral ministries, stakeholders, and policies, hindering coordinated planning and effective decision-making. Recent disasters, such as the 2024 Spain Valencia flood and the 2020 Gjerdrum quick clay landslide in Norway, reveal governance weaknesses, inadequate risk management, and communication barriers, intensifying disaster impacts. These events demonstrate the need for integrated, multi-sectoral coordination, decentralisation, and better risk-informed decision-making. A positive example is Greece's wildfire risk management system, which integrates science and technology for improved governance in DRR. However, gaps in local- and regional-level implementation persist. The TOGETHER project aims to address these challenges, focusing on multi-level and cross-sectoral coordination to build a disaster-resilient society amidst climate change and multi-hazard risks. The final outcome of this project is a toolkit that embodies three innovations: (1) Five interoperability frameworks (legal, organisational, technical, semantic, and cross-domain) to provide FAIR data, (2) a multi-tool system (MTS)- an intelligent AI agent to generate insights using the FAIR data for Disaster Risk Management Governance (DRMG), and (3) DRMG that comprises innovative solutions and existing systems and best practices to enhance multi-level and cross-sectoral interactions within the existing governance systems and protocols for more efficient disaster management coordination. The tool will implement a novel public-private-civic partnership (PPCP) approach in three Disaster Risk Management Innovation Hubs ( Norway, Greece, Spain) to co-create, co-evaluate, and demonstrate the functionalities. Two replication studies in Portugal and Türkiye will showcase the robustness of the toolkit for DRM.

Keywords: disaster risk management,multi hazard governance,public private civic partnership,cross domain interoperability,disaster risk and recovery
Mechanisms of cellular response to errors in mitosis: a new, non-genetic approach to an old question (MitErrA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-07-01
End date: 2029-06-30
Duration (months): 60.0
Total project cost (EUR): 1498111.0
EU funding (EUR): 1498111.0
Participants: 1
Project status: SIGNED

One of the holy grails in cancer biology is to understand how genomic instability, a hallmark source of mutagenesis, arises. However, surprisingly little is known about non-genetic drivers of tumorigenesis. My proposal will delve into the old question of how Mitotic Errors and nuclear Abnormalities (MitErrA) affect cellular homeostasis, from a fresh perspective: the elucidation of non-genetic effects on genome function and cellular adaptation. I recently discovered that micronuclei, a prominent type of errors in mitosis, are a previously unappreciated source of epigenetic instability. This discovery, together with the novel technologies that I developed, will serve as the springboard to address four fundamental questions: 1) How is chromatin state affected in abnormally segregated chromosomes? 2) What are the mechanisms of transcriptional (dys)regulation following errors in mitosis? 3) How is genome organization perturbed in imbalanced genomes? 4) What is the physiological significance of abnormal chromosomes generated by mitotic errors? I will combine cutting edge techniques, such as targeted chromosome manipulation and single-cell genomics, with advanced systems to track mis-segregated chromosomes by live-cell imaging over multiple generations. I will identify additional sources of inherited abnormal nuclear structures (termed “Mit-bodies”) and characterize their DNA damage/repair dynamics and epigenetic alterations. I will study how transcription dynamics are perturbed in daughter cells upon abnormal mitosis and define higher-order genome organization, nuclear positioning and lamina association of mis-segregated chromosomes. Finally, I will investigate long-term cellular adaptations and assess the tumorigenic potential of these abnormal chromosomes. Altogether, these studies will offer the first comprehensive assessment of the non-genetic mechanisms by which errors in mitosis may drive cellular adaptation and tumorigenesis.

Keywords: mitosis,nuclear structures,chromosome segregation,micronuclei,aneuploidy,genome organization,cell adaptation
Advancing Sodium-ion Battery Cycle Life: Understanding Degradation in Hard Carbon Anodes (EISNMR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 276187.92
EU funding (EUR): 276187.92
Participants: 1
Project status: SIGNED

Na-ion battery (NIB) is the most promising technology among the next generation battery technologies. The main issue facing NIB is in their low cycle life. Limited cycle life of Na batteries results from degradation mechanisms occurring at both the cathode and the anode. While multiple cathode materials have been developed, the best-performing anode material remains hard carbon. Despite hard carbon's acceptable energy density, it suffers from inadequate cycle life. Significant efforts have been made to understand Na storage mechanisms in hard carbon. However, little effort has been devoted to understanding the degradation mechanisms and strategies to mitigate them. I propose research spanning multiple scales to evaluate the mechanisms causing degradation in hard carbon anodes and develop strategies to inhibit them, focusing on SEI and charge transfer mechanisms, and their influence by various operating parameters. This work will involve intensive mechanistic studies of Na-ion charge transfer and interfacial processes by conducting in-situ Electrochemical Impedance Spectroscopy (EIS) and Nuclear Magnetic Resonance Spectroscopy (NMR) measurements, which will identify and quantify the contributions of both Na-ion charge transfer and interface to hard carbon degradation. I will employ hard carbon symmetric cell configuration that allows for detailed analysis without the contribution from other electrodes. I will scale this mechanistic work with various parameters including electrolyte composition and temperature. The results will identify the primary contributors to the low cycle life of hard carbon anodes and bring strategies to extend their cycle life.

Keywords: na ion storage,solid electrolyte interphase,electrochemical impedance spectroscopy,nuclear magnetic resonance spectroscopy,cycle life
LAgrangian Climate Risk and Impact Attribution (LACRIMA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Belgium
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 1999590.0
EU funding (EUR): 1999590.0
Participants: 1
Project status: SIGNED

Under a continued increase in global warming, extreme events such as heatwaves will further rise in frequency, intensity, and duration over the next decades. Climate change impact studies routinely assess hazard and exposure change across discrete time windows, but thereby fail to grasp how vulnerability and climate risk evolve across a person’s lifetime. Conversely, demographic research has a long tradition of assessing population processes and vulnerability from a cohort perspective, but generally ignores climate impacts. This project will develop novel concepts and methodologies to express climate change impacts and risk from a cohort perspective. More specifically, the project pursues (i) to reconstruct two iconic climate change impacts on people around the world using machine learning (heat-related mortality and burned area), (ii) to uncover age-specific vulnerability to climate extremes including heatwaves, wildfires, river floods, droughts, tropical cyclones, and crop failures, (iii) to detect and attribute changes in lifetime extreme event exposure and climate impacts on mortality across generations and regions, (iv) to quantify how these attributable cohort impacts change country-level life expectancy around the world under a range of warming scenarios, and finally (v) to project how lifetime exposure to extreme events including compound events may trigger irreversible impacts under scenarios of temporary overshooting of long-term warming targets. By bridging physical climate science, demography, and planetary health, LACRIMA will comprehensively identify whether and where people will live an unprecedented life in terms of climate impacts, and how collective mitigation choices can alter the climate change burden on current young generations around the world.

Keywords: detection and attribution climate extremes inter sectoral impact modelling isimip community land model
Harmony within society (HWS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1597750.0
EU funding (EUR): 1597750.0
Participants: 1
Project status: SIGNED

Our living together is confronted with new challenges, as our modern world widens our public sphere and smushes together groups with different value systems. In turn, agents take refuge in safe spaces, where their behavior and speech are protected from bad inferences. This ambitious project aims at proposing a unified framework- building on the role of the dissemination of personal information- to study social interactions, and at fostering the academic community’s engagement on the study of these new challenges. The first part will build a framework for divisive behaviors (for which agents do not agree on what’s right and wrong). It will endogenize safe spaces and investigate their dark side (externalities, tribal behaviors, outings) as well as their (in)ability to foster the learning of social norms. It will also study theoretically and empirically how society and organizations create a common identity by defining legitimate conversation and designing common narratives. The second part will challenge the received wisdom that transparency is beneficial for consensual behaviors and will bring evidence in this regard; the argument will be based on the first modelling of moral licensing, then applied to the coexistence of public and private spheres; and on the formalization of when the right to oblivion is desirable. Finally, and in line with the commonality argument, the project will investigate coopetition, with implications for international cooperation in innovation and competition policy.

Keywords: privacy public sphere divisive behaviors safe spaces moral preferences and narratives coopetition innovation
BIOMASS VALORIZATION FOR SUSTAINABLE AND HIGH QUALITY FIBER MATERIALS (Bio-LUSH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Public-private partnerships
Destination: Circular Bio-based Europe
Action type: Research and Innovation actions
Partnership: CBE (JU-JTI)
Countries involved: Sweden,Finland,France,Serbia,Italy,Netherlands,Germany,Switzerland
Call: Sustainable fibres biorefineries feedstock (HORIZON-JU-CBE-2022, 2022)
Start date: 2023-05-01
End date: 2027-04-30
Duration (months): 48.0
Total project cost (EUR): 4479506.25
EU funding (EUR): 4479506.25
Participants: 13
Project status: SIGNED

Bio-LUSH addresses a growing need and demand to utilize underexploited biomass feedstocks for sustainable and high-quality fibre extraction. Within the project, we will establish innovative processes for optimal biomass refining and fibrillation to nanoscale to convert obtained sustainable fibres into functional biobased materials. Along with hemp hurd and forest residues, selection of other green underexplored biomass feedstocks (nettle and seagrasses) was based on availability in Europe as well as ecological benefits such as utilization of marginal lands, biodiversity protection and without competing with food production. Also, traditional breeding through crosses will be used to improve the agronomical and fiber yield properties of the identified “novel crops”. Certification procedures and a standardization roadmap will be established in a form of nanocellulose quality index to assure effective benchmarking within the obtained (nano)fibres. Moreover, the results of advanced characterization of feedstock, fibers and biobased products will be collected in dataset to employ machine learning tools to design biobased materials based on fibres properties. We will demonstrate the biomass processing and manufacturing (both at TRL5) of biobased products such as edible packaging, antibacterial textiles and 3D printable bio(nano)composite filaments for impact resistant car interior products. The Bio-LUSH consortium brings together actors from the entire value chain, comprised of 12 partners from 8 countries including 7 industry partners (3 SMEs, 4 LEs), who will ensure that the developed solutions will be industrially viable (environmentally, economically, socially). Bio-LUSH includes activities on enhancement of social acceptance of the materials to facilitate the route to market, which will be supported by a dedicated business plan. Integration of Agro sector/farmer communities and access to EU feedstock is ensured through advisory board member, Bast Fibre Technology.

Keywords: biomass valorisation,,nanocellulose,fibers,textiles,packaging,sustainability
PREVENTING GROUNDWATER CONTAMINATION RELATED TO GLOBAL AND CLIMATE CHANGE THROUGH A HOLISTIC APPROACH BASED ON MANAGED AQUIFER RECHARGE (MAR2PROTECT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Clean Environment and zero pollution
Action type: Research and Innovation actions
Countries involved: Portugal,Italy,Spain,South Africa,Switzerland,Netherlands,Lithuania,Tunisia
Call: Preventing groundwater contamination and protecting its quality against harmful impacts of global and climate change (HORIZON-CL6-2022-ZEROPOLLUTION-01, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 4143681.25
EU funding (EUR): 3995749.0
Participants: 16
Project status: SIGNED

The impact climate and global change (CC and GC) is endangering human health, food security and biodiversity. Urgent action is needed to achieve 2030 zero pollution goals. MAR2PROTECT will provide a holistic approach to prevent groundwater (GW) contamination from GC and CC impacts based on a new-generation managed aquifer recharge (MAR). The core of the innovative MAR is the M-AI-R DSS that will incorporate technological and societal engagement information using an AI-based evaluation to improve GW quality. To ensure a high replication potential, M-AI-R DSS will collect information from 5 demo sites in EU (PT, IT, ES, NL) and 2 in non-EU countries (TN, ZA) which were carefully chosen by their degree of maturity from previous successful projects and a wide range of settings in terms of climatic conditions, water sources, type of pollution, MAR scheme and political/societal context. All technologies will be tested and validated until TRL5. MAR2PROTECT will ensure a strong engagement of civil society in GW prevention actions, up to a SRL equal to 6. The project will involve national and EU policy makers that, in collaboration with a Community of Practice formed by worldwide experts, will guarantee the strengthening EU policy for the prevention of GW contamination. Thanks to its holistic approach and to the high replicability of its results, MAR2PROTECT will lead to a marked enhancement in GW protection across the EU and beyond, and to the generation of knowledge for the transition to a sustainable water management. The consortium includes 8 partners and 1 affiliated entity from 6 different EU-countries and Switzerland and 2 international partners from Tunisia and South Africa: 2 Universities (UNIBO, KTU), 7 RTOs (NOVA-COO, CIIMAR, CETAND +AQUA, IHE, IT, ISSBAT, SUWI) and 1 Association (FEUGA). In addition, the inclusion of 3 large water utilities as associated partners and a policy maker from ZA will lead to a relevant enhancement of the project impact.

Keywords: climate change,global change,groundwater,mar,aquifer,pollution,social,removal,biodegradation,water
Neural mechanisms of self-tickle cancellation in humans (NeuroSelfTickle)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 232916.16
EU funding (EUR): 232916.16
Participants: 1
Project status: SIGNED

In perception, neural responses are never identical, even to the same sensory stimuli. This variability is particularly evident in the somatosensory domain: why does the same tactile input feel ticklish when applied by others but not by ourselves? The phenomenon of self-tickle cancellation has intrigued philosophers, biologists, and psychologists for centuries. Motor control theories propose that self-generated movements elicit top-down predictions in the cerebellum that suppress bottom-up tactile input in the somatosensory cortex. However, how these top-down and bottom-up signals interact in the somatosensory cortex – and particularly across its different layers – to cancel self-tickle is unclear. NeuroSelfTickle aims to unravel these complexities with advanced electroencephalography, psychophysical modelling and laminar magnetoencephalography. The project seeks to identify neural markers of tickle sensation, map layer-specific cortical activity in top-down and bottom-up signal integration, and apply these insights to understand the neurocognitive mechanisms of self-tickle cancellation. This interdisciplinary approach combines well-established motor control theories with cutting-edge neuroimaging techniques and state-of-the-art haptic robotics, allowing for highly controlled yet naturalistic self-touch stimulation. The findings are expected to provide fundamental insights into how self-generated predictions influence neural computations and enhance our understanding of brain disorders where self-tickle cancellation fails, such as schizophrenia and autism. NeuroSelfTickle will create a synergy between the applicant's expertise in somatosensory neural oscillations and excitability fluctuations, and the host lab's pioneering research on tickle perception and self-tickle cancellation. The Donders Institute, along with Dr. Kilteni's lab, will provide the necessary theoretical knowledge in sensorimotor control, as well as technical expertise and support in neuroimaging.

Keywords: somatosensory perception,neural variability,motor control,eeg,meg,layer specific cortical dynamics
Illuminating the enteroviral life cycle (VIRLUMINOUS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Immunity, Infection and I mmunotherapy
Panel description: The immune system , related disorders  and their mechanisms , biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases , innovative imm unological tools and approaches , including  therapies
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2023-04-01
End date: 2028-03-31
Duration (months): 60.0
Total project cost (EUR): 2478311.25
EU funding (EUR): 2396392.0
Participants: 1
Project status: SIGNED

Enteroviruses are highly prevalent pathogens that have enormous clinical and socio-economic impact. Well-known examples are poliovirus, coxsackievirus, enterovirus-A71, enterovirus-D68, and rhinovirus. Although important insights have been obtained in the enteroviral life cycle, many important questions remain unanswered due to shortcomings of current imaging and biochemical methodologies. There is a high need for novel technologies that allow sensitive and real-time observation of the dynamics and localisation of viral RNA, viral proteins, and host factors at the single-cell level. My long-term goal is to understand enterovirus replication and translate knowledge into the development of antiviral drugs. My lab has a long-standing track record and has made many important contributions to understanding the molecular mechanisms of enterovirus replication and the formation of viral replication organelles. Recently, we constructed a reporter virus that in combination with high-resolution microscopy allowed for the first time to visualize translation, and the regulation thereof, of single (entero)viral RNAs in living cells. The goal of this project is to visualize and dissect the spatial and temporal regulation of different phases of the enterovirus life cycle. As a first step, novel recombinant reporter viruses for application in real-time imaging technologies will be developed. These viruses will be used to study viral RNA replication, virus assembly, and pre-lytic virus release in living cells. Moreover, they will be instrumental to study the structure and composition of the viral replication organelles and the associated replication complexes through advanced cryo-electron microscopy and tomography technologies, and proteomics/lipidomics analysis, respectively. This project will lead to important new insights into the molecular interplay between enteroviruses and their hosts, which is essential for developing urgently needed antiviral drugs.

Keywords: enterovirus,replication,encapsidation,release,replication organelles,host factors,virus host interactions