Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The We in Times of Physical Distancing. From face-to-face interactions to enduring we-identities (Enduring We)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 184707.84
EU funding (EUR): 184707.84
Participants: 1
Project status: SIGNED

What does it mean to feel, act, and think as member of a we in times of cultural upheaval and uncertainty, physical distancing and social isolation? In the aftermath of a pandemic crisis with its consequent confinement, a renewed critical reflection on how to maintain the social ties that bind us together is of urgent societal and political significance. As the first multi-level approach to the topic, this project aims to develop a novel theoretical framework to account for the constitution of configurations of the “we” that go beyond the here and now and involve the plural position of you and they. Proceeding from the working hypothesis that in order to meet this goal one need to shift the theoretical focus from the “You” to the “Third” that is to say, from dyadic face-to-face (immediate) relations of reciprocity between I and You, to ternary relations of "mediated reciprocity", involving the figure and the functions of a “third party”, the project will integrate hitherto unrelated phenomenological investigations on the “we” with current social theories on the roles of the “third” in the social sciences. It will also combine theoretical work with the analysis of two very telling case studies and historical examples. In so doing, it will break new ground by elaborating a particular aspect of the relation between the we, the inter-subjective dyad (I-you), and the third and offer a new phenomenological paradigm to account for the complexity of the social relation involved in enduring and normatively mediated configurations of the “we” that is, at the same time, an innovative way of conceiving the “we” in view of the ethical and political stakes it entails and a renovated approach to political questions related to the constitution of shared identities. The project will also explore the implications of this new paradigm in the political field for addressing the question of how we are to cultivate a sense of shared identity (European identity) despite separatist drifts.

Keywords: social phenomenology,we perspective,group identification,collective identities,social ontology,the relation between the we,the i you dyad and the third party,social sciences
Aggressive T cell Lymphomas, integrated clinical and genomic analysis for a precision medicine. (PRECISMEDLYM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-28
End date: 2022-09-27
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Lymphoid leukemias and lymphomas represent frequent areas of the tumour pathology. Recent Integrative clinical and molecular studies allows to identify concrete disorders where a precise recognition leads to a specific treatment with a minimum toxicity and maximum clinical benefit. Even though there have been many progress during last years, there still persist numerous conditions with low survival probability and high side effects of the received treatments. The introduction of the precision medicine in lymphoid neoplasms is new and challenging due to the scarce knowledge about disease pathogenesis, targeted therapies and predictor markers, immunotherapy role and poor experimental models. T-cell lymphoma tumors present a dismal survival probability dismal (25% for Peripheral T-cell lymphoma) in patients, and the molecular mechanism underlying their high rate of lack response to treatments and relapse is poorly understood. Furthermore, patients with lymphoproliferative disorders often have complex (multiclonal) or mixed lymphoproliferative disorders. This project aim the consolidation of the precision medicine in the diagnosis and therapy of these disorders, thus facilitating the treatment of each patient according its disease, with specific therapy according to the integral characterization of its disease, thus reducing toxicity and improving the therapy efficacy. The project focuses on complex lymphoproliferative diseases characterized by clinical aggressiveness with low therapeutic response, tumor heterogeneity and patterns of dependency / interaction with the microenvironment. The success of the project requires in first instance to improve in the knowledge of the molecular basis of the disease and subsequently in the identification of precise tumour types and patient stratification, thus facilitating the identification of markers for targeted therapy, using gene expression and mutational signatures.

Keywords: lymphoma,precision medicine,microenvironment
A distributional MOdel of Reference to Entities (AMORE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: Spain
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-02-01
End date: 2023-01-31
Duration (months): 72.0
Total project cost (EUR): 1499805.0
EU funding (EUR): 1499805.0
Participants: 1
Project status: CLOSED

When I asked my seven-year-old daughter "Who is the boy in your class who was also new in school last year, like you?", she instantly replied "Daniel", using the descriptive content in my utterance to identify an entity in the real world and refer to it. The ability to use language to refer to reality is crucial for humans, and yet it is very difficult to model. AMORE breaks new ground in Computational Linguistics, Linguistics, and Artificial Intelligence by developing a model of linguistic reference to entities implemented as a computational system that can learn its own representations from data. This interdisciplinary project builds on two complementary semantic traditions: 1) Formal semantics, a symbolic approach that can delimit and track linguistic referents, but does not adequately match them with the descriptive content of linguistic expressions; 2) Distributional semantics, which can handle descriptive content but does not associate it to individuated referents. AMORE synthesizes the two approaches into a unified, scalable model of reference that operates with individuated referents and links them to referential expressions characterized by rich descriptive content. The model is a distributed (neural network) version of a formal semantic framework that is furthermore able to integrate perceptual (visual) and linguistic information about entities. We test it extensively in referential tasks that require matching noun phrases (“the Medicine student”, “the white cat”) with entity representations extracted from text and images. AMORE advances our scientific understanding of language and its computational modeling, and contributes to the far-reaching debate between symbolic and distributed approaches to cognition with an integrative proposal. I am in a privileged position to carry out this integration, since I have contributed top research in both distributional and formal semantics.

Keywords: computational semantics,semantic theory,distributional semantics,semantics,reference,neural networks,distributed representations
Approximation of Functions and Fourier Multipliers and their applications (AFFMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-11-01
End date: 2018-10-31
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

This research project is concerned with the following three topics in approximation theory and Fourier analysis: 1) Simultaneous approximation of functions and their derivatives in Lp, 0<p<1. We expect to investigate classes of functions and different methods of approximation for which the problem of simultaneous approximation is solvable, and to obtain estimates for the errors of the best approximation of functions and their derivatives for particular methods of approximation in Lp, 0<p<1; 2) New inequalities for moduli of smoothness of functions in Lp, 0<p<1. We expect to find the classes of functions for which the direct and inverse inequalities for moduli of smoothness of functions and their derivatives hold, and to investigate the sharp Ulyanov inequality for different concepts of smoothness; 3) Fourier multipliers and families of multiplier operators in Lp, p>0. We expect to obtain sufficient conditions of the boundedness for such operators in terms of the simultaneous behavior of a multiplier and its derivatives in different functional spaces, and to apply such conditions for solving problems from this proposal. In our approaches we will combine the methods from approximation theory and Fourier analysis simultaneously, contrary to the previous research concerning the mentioned tasks. Moreover, by using and developing the newly introduced concepts of families of multiplier operators in Lp, 0<p<1, we will provide powerful and universal tools for solving the problems of this proposal as well as for further analysis of operators and related questions in the spaces Lp, 0<p<1. Working on the proposed research tasks in the teams of very qualified specialists will allow the experienced researcher to enhance his competence in terms of skills acquisition through advanced training, international and intersectoral mobility, to develop a long-lasting research cooperation and to increase the impact of his future activities on European and Ukrainian society.

Keywords: simultaneous approximation,moduli of smoothness,lp spaces,0 p 1,fourier multipliers
Novel metrology tool for more flexible and affordable 3D validation of large industrial components (NIPUNA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Finland
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-07-01
End date: 2016-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In every year, European machine industry companies import >€300 billion worth of components and parts, most of which need to meet strict accuracy requirements. In many cases, the services of independent quality-checking subcontractors are used, costing up to 25% of the total cost of procurement. Sampo has been involved in many projects in the area of industrial metrology and defectoscopy. During these projects, a total of 10 machine industry companies (incl. 6 existing customers) have expressed their need for a tool that could precisely verify the key measurements of large industrial components, but be both more mobile and affordable compared to currently available systems. Sampo is well-positioned to develop such solution based on its proprietary SignSense technology which can identify and measure complex objects with up to 0.01 mm precision, and has already been used to build customized machine vision solutions. We are currently evaluating the feasibility of a solution that would scan the product with a manual contactless scanner in a short time, transfer data to a computer and get relevant measurements by software processing. Due to mobility and affordability advantages, it is assessed to reduce the cost of quality-check down to 8-9% of the total procurement, saving up to €1M in case of €5M procurement. NIPUNA project is aiming to estimate the size of the target market, validate the advantages of the proposed solution, specify end-user needs (precision, mobility, cost), evaluate off-the-shelf hardware components for the system, update the business plan and provide high-quality input for SME Phase 2 project. 3D metrology market is expected to reach $2.2 billion by 2020, growing at CAGR of 7%. Sales of the proposed measurement system would be immediate and could generate nearly €1M within first year by just serving our existing customers. Commercialization of the solution would mean breakthrough for Sampo, increasing revenues by an estimated €16.5M in 2022.

Keywords: metrology,defectoscopy,verification,industry
TECHNOLOGY FOR THE IMPROVEMENT OF SPORTS PERFORMANCE IN NON-PROFESSIONAL CONTEXTS (WIMUACT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Realtrack Systems is a company specialising in the development and commercialisation of sports and health-oriented innovative technological solutions whose goal is to improve performance and well-being by monitoring and analyzing various parameters related to participation in sports activities. The use of technology applied to sports has been a growing trend in the recent years, particularly significant among non-professional athletes who are increasingly interested in using technology to improve their personal performance. These individuals demand products in this line that are adapted to their needs, that is, products with high-tech features that are reasonably priced, easy to use and adapt to any sports discipline. WIMU Active is the solution developed by Realtrack Systems for this market segment; consists of a small and robust wearable device with associated software, for enhanced data capture and advanced monitoring analysis used in performance improvement of key parameters related to participation in competitive team sports activities, cost effective to specifically fill the elite amateur and sub professional sportsman segment need.

Keywords: technology for sports,sports innovation,high performance sports,sports monitoring,sports analysis
Transforming the Customer Experience through Smart, Interactive and Pervasive Proximity Services (bubbleOn)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: France
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

bubbleOn is a fully integrated ecosystem to provide proximity services (marketing, custbubbleOn is a fully integrated ecosystem to provide proximity services (marketing, customer satisfaction, etc.) based on a non-intrusive device (presented as a charging station, the bubble) and a service platform that seamlessly allows creating and using adaptive content depending on each user profile, location, time and context. All of this enables advanced marketing features that fosters marketing intelligence strategy. bubbleOn is the only solution including a proximity service multi-technology device, a content management system (CMS) and an orchestrator to provide a non-intrusive, seamless, turnkey solution for retailers to deliver proximity marketing services in their stores. bubbleOn project follows three principles: 1. Extreme User Experience: from our physical device –the bubble–, designed by a prestigious studio in Paris, to our content management system (CMS) and including the service portfolio designed for end users (i.e. 1/X promotion described in section 1.3), everything is created to impact positively in the mind of people, to ease common and not so common actions and to be pretty, friendly and appealing. 2. Omni-channel, one step further: our solution integrates the offline world with online resources to provide individuals with the most exciting experience (one can go to a supermarket and get his full basket refunded, suddenly!). We mix proximity technologies (beacons, GPS, Wi-Fi…) with marketing techniques (coupons, promotions, loyalty programs, sales…) and produce automated campaigns in real time. 3. Taylor made marketing: thanks to our business intelligence orchestration, implemented in our orchestrator, we are able to deliver absolute customised content to each individual entering a shop, a bank branch or a station. This opens a new door to deliver valuable content to the customers, by mean of non-intrusive marketing, gamification and other innovative methods.

Keywords: proximity marketing,proximity services,smart city,smart cities,beacon,omnichannel,adaptive content,customized marketing,customised marketing,marketing intelligence
Host Protective Engineering of Cancer Immunity by Targeting the Intracellular Immune Checkpoint NR2F6 (HOPE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Austria
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 2484325.0
EU funding (EUR): 2484325.0
Participants: 1
Project status: SIGNED

Because of its biological complexity, cancer is still poorly understood. Chronic inflammation has been shown, both experimentally and epidemiologically, to be a predisposition to, and also an inseparable aspect of clinically prevalent cancer entities. Therefore, a detailed understanding of both tumour and immune cell functions in cancer progression is a prerequisite for more successful therapeutic startegies. My team was the first to reveal the lymphocyte-intrinsic PKC/NR2F6 axis as an essential signalling node at the crossroads between inflammation and cancer. It is the mission of this project to identify molecular signatures that influence the risk of developing tumours employing established research tools and state-of-the-art genetic, biochemical, proteomic and transcriptomic as well as large scale CRISPR/Cas9 perturbation screening-based functional genomic technologies. Defining this as yet poorly elucidated effector pathway with its profoundly relevant role would enable development of preventive and immune-therapeutic strategies against NSCLC lung cancer and potentially also against other entities. Our three-pronged approach to achieve this goal is to: (i) delineate biological and clinical properties of the immunological PKC/NR2F6 network, (ii) validate NR2F6 as an immune-oncology combination target needed to overcome limitations to "first generation anti-PD-1 checkpoint inhibitors" rendering T cells capable of rejecting tumours and their metastases at distal organs and (iii) exploit human combinatorial T cell therapy concepts for prevention of immune-related adverse events as well as of tumour recurrence by reducing opportunities for the tumour to develop resistance in the clinic. Insight into the functions of NR2F6 pathway and involved mechanisms is a prerequisite for understanding how the microenvironment at the tumour site either supports tumour growth and spread or prevents tumour initiation and progression, the latter by host-protective cancer immunity.

Keywords: nsclc lung carcinoma,tumour immunity,cd4 and cd8 effector t cells,orphan nuclear receptor nr2f6,intracellular immune checkpoint,innovative immune based human cancer therapy regimen
Innovative Electrochemical Multiplex Biosensor for Detection and Quantification of Clinically Relevant Circulating miRNAs (INFORM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

Radical prostatectomy is currently the most used curative procedure in the treatment of localised prostate cancer (PCa). However, in 30-50% of interventioned patients Prostate Specific Antigen (PSA) increases on post-operatory, meaning that the cancer has spread. The rise in PSA is due to imprecision in preoperative staging, suggesting patients already had distant, undetectable disease. Another issue is that elevated serum PSA is not specific to malignant prostate disease, it cannot differentiate between indolent tumours or those that are/will become life threatening. Fatal cancer is most often due to metastatic disease but histopathological examination of biopsy or traditional imaging methods fail to detect the early disseminated circulating biological information highlighting the need for approaches that can detect biomarkers of cancer spreading at an early stage. Circulating amounts of non-coding microRNA (miRNA) have been shown to have a biological impact and to be clinically associated with cancer and are now seen as a new class of biomarkers that will allow earlier and more accurate diagnosis. The objective of INFORM is to develop an innovative electrochemical multiplex biosensor for detection and quantification of a panel of clinically relevant circulating miRNAs in intermediate-risk PCa patients that will be submitted to potentially curative surgery. By focusing on the development, optimisation and validation of a biosensor for miRNA profiling in PCa, discrimination of patients with local disease from those with more advanced PCa will be possible. The biosensor will rely on the selectivity of the sandwich assays and on the sensitivity of the photoelectrochemical detection to quantify, at the sub-fM level, circulating miRNAs that are associated with PCa. The quantification of these overexpressed miRNAs will lead to a better overall management of the disease and allow for a more informed decision by the medical doctor, providing personalised medicine.

Keywords: biosensor,mirna,prostate cancer,multiplex,liquid biopsy,photosensitiser