Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Using a principled causal approach for causal queries: the Ostracism Causal Project (O-Causal)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 1499500.0
EU funding (EUR): 1499500.0
Participants: 1
Project status: SIGNED

Ostracism—being ignored or excluded— manifests in many forms in everyday life, such as ghosting, bullying, microaggressions, and cancel culture. For decades, psychologists have examined its real-world impacts, including depression, suicide risk, violence, extremism, societal divides, and inequalities. However, much of this evidence is not causal due to the absence of tools for quantifying the causal effects of naturally occurring exposures in psychological science. Relying on the existing approach will continue to distort scientific conclusions, impede theory advancement, and misguide policies. Re-thinking the current causal approach is critical and overdue. The O-Causal project aims to address this gap by applying the causal inference framework—a principled and well-established approach for causality—to ostracism research. This project will advance the field in four key ways: 1) establishing a fundamental understanding of the prevalence and distribution of lived ostracism experiences in real-life settings; 2) quantifying the time-varying ostracism effects across a wide range of outcomes in behavioral, economic, health, and wellbeing domains; 3) uncovering inequalities in ostracism and identifying at-risk populations; and 4) reformulating causal questions to generate insights that inform public policies aimed at fostering positive social change. To achieve these goals, I will construct a comprehensive, population-based dataset by integrating large longitudinal panel data, daily diary entries, and ecological momentary assessments. Using advanced causal inference techniques and innovative causal estimands, this project will reveal how everyday experiences of ostracism can escalate into serious societal issues, identify vulnerable groups, and provide a foundation for policy development. Ultimately, this project will reorient ostracism research and psychological science toward a more rigorous causal approach toward scientific rigor and real-world impact.

Keywords: causal inference
Enabling transition towards circular and systemic BIOeconomy model regions by a Regions-to-Regions approach (BIO2REG)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Coordination and support actions
Countries involved: Germany,Spain,Greece,Belgium,France,Sweden,Iceland,Czechia
Call: Supporting the fair and just transition from GHG-intensive economies facing challenges towards circular bioeconomy model regions (HORIZON-CL6-2023-CIRCBIO-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2331982.08
EU funding (EUR): 1977398.33
Participants: 9
Project status: SIGNED

Sustainable bioeconomy transition is an acknowledged pathfinder to achieve the Green Deal ambitions. A regionalised bioeconomy is seen as a promising leverage point for green growth. Many European regions have already adopted bioeconomy strategies. However, the majority of regional stakeholders lack actionable knowledge to translate them into practice and embed them into society, industry and research by simultaneously considering planetary boundaries. Regions heavily relying on GHG-intensive economies - that are particularly critical for realising the Green Deal - face even more challenges to unlock their bioeconomy potential. The concept of bioeconomy model regions tackles the urgent need to concretise bioeconomy into tangible transition measures. Model regions are characterized by a systemic approach, draw on technological and societal innovations, are able to link sectors and contribute to sustainable development in economic, ecological and social dimensions. BIO2REG therefore aims to enable regional stakeholders of GHG-intensive economies to unlock their regions’ bioeconomy potential by transitioning towards model regions. BIO2REG paves the way for regional stakeholder to actively initiate and shape transition based on a regions-to-regions approach. Embedded in a network of regions for regions, interregional exchange and cooperation will be facilitated. Specifically, regional stakeholders will be capacitated by i) provision of a regionalisation concept for model regions, ii) mapping best practices on circular and sustainable bioeconomy, iii) guides for bioeconomy potential assessments, iv) mentoring and training services v) formation of transition alliances and v) policy recommendations to adapt strategies and funding. A key component is the adoption of a multi-actor approach by co-creating tools and guides with regional stakeholders as well as engaging with regions by guided on-site exchanges with stakeholders from other regions.

Keywords: green transition,bioeconomy model region,bioeconomy regionalisation,ghg intensive economies,green growth,multi actor approach,sustainable bioeconomy
Open(ing) Research in Central Asia: consolidating a culture of research ethics, data management, and open science, in Eurasia and beyond (ORCA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Latvia,Lithuania,Estonia,Germany,Georgia,Ireland,Italy,Moldova, Republic of,Türkiye,Tajikistan,Uzbekistan,Kyrgyzstan,Turkmenistan,Kazakhstan,Azerbaijan
Call: MSCA Staff Exchanges 2023 (HORIZON-MSCA-2023-SE-01, 2023)
Start date: 2025-03-01
End date: 2029-02-28
Duration (months): 48.0
Total project cost (EUR): 1656000.0
EU funding (EUR): 1656000.0
Participants: 18
Project status: SIGNED

With a focus on five Central Asian countries (Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan), ORCA is a pilot programme dealing with science performance and science management with a specific focus on economics and social sciences. Across the world, the academic ranking business has turned into a multi-million industry with dozens of surveys implemented to rank universities, bringing with it pressure to improve performance on these same rankings. As a result, most universities have been attempting to improve their performance measured against the metrics and criteria used. While debates advance within the EU and high-performing countries, training paths to increased research performance remain limitedly available. Central Asia is a good starting point to address this gap, given the excellent tradition it has in hard sciences (especially engineering) that has resulted in continued international collaborations, while research in the economic and social sciences has remained largely under-developed. ORCA will produce a generation of experts in research policy with focus on the region as a pilot attempt to a) contribute to informing EU (and member state) policies and attitudes towards the region, and how to enhance excellent and open science, and b) act as multipliers and contribute to the formation of further specialists that will then be able to explore and operate in other regions. ORCA brings together 18 leading institutions and organisations across Eurasia, with experience on science excellence and sufficient links with national governments to influence the development of science in the region, including policies on ethics, integrity, open access and data management. The effects of ORCA will live on through the formation of a dense network based on secondments and knowledge exchange, building a vibrant community of researchers interested in enhancing collaboration, knowledge exchange, co-authorship, seminars, presentations and future projects.

Keywords: open science,anti predatory training,research management,open access,research culture
Safe, ClimAte Resilient Infrastructure (SAFARI)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Innovation actions
Countries involved: France,Greece,Spain,Finland,Norway,Belgium,Portugal,Lebanon,Italy,United Kingdom
Call: Climate resilient and safe maritime ports (HORIZON-CL5-2023-D6-01, 2023)
Start date: 2024-05-01
End date: 2027-10-31
Duration (months): 42.0
Total project cost (EUR): 7307464.58
EU funding (EUR): 6240265.33
Participants: 26
Project status: SIGNED

SAFARI’s project aims to develop a generic digital platform for resilient port infrastructure, connected to large port communities, facing extreme weather events, with emergency management modules fed by operational, maintenance and analytical modules. The implementation of the SAFARI project will allow to: Maintain the port operation at 80% of capacity during the disruption periods; Optimize the allocation of multi-modal transport assets before and after the disrupting event to reach 20% of modal cargo shift with less environmental footprint and to minimize the downtime during extreme weather events; Develop resilience measures to strengthen existing port infrastructure against extreme weather events. Ensure the safety of personnel, vessels and protect the biodiversity; Build a governance model and guidelines to address climate risks and hazards for port infrastructure. The SAFARI consortium aims to deploy new measures reaching a TRL 7 by the end of the project in different maritime and inland infrastructures of port partners, from North Sea, Atlantic Ocean and Mediterranean Sea, that can minimize the impacts of the disturbances issued from the extreme weather events. Three pilot demonstrators are selected from the littorals of Europe, namely Port of Dunkirk (FR), Port of Seville (ES) and Port of Lisbon (PT).

Keywords: port capacity,model shift,bio diversity,extreme weather events,large scale digital platform,maintenance,safety
Sensitive periods for audition: Teenagers with Normal Hearing & Hearing Loss (SensationaHL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1476432.0
EU funding (EUR): 1476432.0
Participants: 1
Project status: SIGNED

Orienting oneself in a crowded playground, understanding the teacher’s explanation despite the surrounding chatter, lip-reading to support auditory perception in noisy backgrounds: these are all complex but essential skills for navigating lively schools. In children with normal hearing, the auditory system is functionally mature by 6 months of age. Yet complex auditory processing remains immature until mid to late adolescence. Strikingly, adolescence is characterized by the onset of puberty, which triggers a cascade of hormonal changes that drive neural plasticity, and vice-versa. The overarching hypothesis of SensationaHL is that adolescence might present a second sensitive period for complex auditory processing. Just like puberty is a gradual process spanning years, sensitive periods unfold over time. In this project, I propose a multi-method approach to advance our understanding of maturation of complex auditory processing at adolescence. Specifically, I will combine neuroendocrinology, neuroimaging and psychophysics to identify the mechanisms that govern sensitive periods as they unfold over time. First, I will zoom in on the onset of puberty as a potential trigger for heightened plasticity associated with sensitive periods. Next, I will investigate the effect of altered auditory input (due to hearing loss, noise exposition or auditory training) on maturation of complex auditory processing in adolescents. Last, I will focus on the braking factors that contribute to a decrease in plasticity observed at the end of adolescence. SensationaHL uses an innovative multidisciplinary perspective to tackle a remaining challenge in the field of (developmental) auditory cognitive neuroscience. It will have significant impacts on public health (i.e., prevention and clinical management of hearing loss), language education (i.e., speech perception in challenging backgrounds in children) and theoretical understanding of sensitive periods across the lifespan.

Keywords: psychoneuroendocrinology auditory processing hearing loss
Nonlinear inversion of correlation waveforms with hierarchical reconstructions (INCORWAVE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1416541.0
EU funding (EUR): 1416541.0
Participants: 1
Project status: SIGNED

Waves propagating through a complex medium provide a non-invasive way to probe its interior structures. In ambient noise imaging, the input data are the cross-correlation of the stochastic wavefields. To reconstruct the properties of the medium, the waveform inversion is formulated as an optimization problem involving a misfit function whose convexity plays a critical role in the achievable spatial resolution of the inversion results, especially in the absence of a priori information about the medium. Current inversions are often limited by computational cost, cross-talk between the physical quantities, and the use of single-scattering approximations. Project INCORWAVE proposes to create a new mathematical and computational framework for nonlinear inversion of full waveform cross-correlation. Two specific problems are considered: first, for the reconstruction of geophysical visco-elasticity tensors with applications to Earth's subsurface monitoring; secondly, for the reconstruction of three-dimensional flows in the Sun to characterize the poorly understood properties of deep solar convection. To improve the convexity of misfit functions, the inversion procedure of project INCORWAVE will follow a hierarchical progression which is established by selecting subsets of input data, unknown parameters, and frequencies. The choice of each of these subsets, as well as the associated misfit function, is controlled by criteria in form of convergence estimates. Indispensable to meaningful inversion is accurate modeling operators that describe the physics under consideration and that are adapted to the treatment of real data. For the reconstruction of the elasticity tensor, the project will develop a solver in terms of P- and S-potentials for heterogeneous media. A 3D global Sun vector-wave solver is created for the inversion of the convection component of the solar flow that does not bear symmetry.

Keywords: inverse problems wave equations helioseismology convergence estimates hybridizable discontinuous galerkin discretization time harmonic waves
Prime editing to Repair Inherited Metabolic Errors: in vivo gene correction for human genetic disease (PRIME)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1499968.75
EU funding (EUR): 1499968.75
Participants: 1
Project status: SIGNED

Treatment options are insufficient for the majority of genetic metabolic diseases. Methylmalonic acidemia (MMA) is one such severe metabolic disease. With current therapeutic strategies, patients still develop metabolic decompensations, brain damage, kidney failure, and have a lifelong risk to acutely become blind. Repair of the genetic cause of disease would revolutionize outcomes for these patients, especially with increasing detection in neonatal screening programs. This makes it possible to correct the cause of disease prior to the onset of irreversible damage. However, efficiency, safety, versatility and delivery of precise gene editing is not yet sufficient for in vivo gene-correction therapies. The aim of this proposal is to develop an in vivo gene-editing therapy program for patients with metabolic diseases targeting the liver, where most metabolic genes are highly expressed. As a proof-of-principle, I will repair genetic causes of MMA, validate this in personalized cells and mouse models, and lay the groundwork for human trials. To this end, I will: (1) Generate a clinically applicable gene-editing technique. I recently demonstrated that the novel gene-editing technique prime editing could accurately correct different mutations in patient-derived organoids. Using an innovative reporter and patient-derived organoids, I will develop prime editing into an efficient and safe strategy that can correct >90% of patient mutations. (2) Create a system for in vivo delivery of the prime-editing machinery with lipid nanoparticles to target the liver, using patient-derived liver organoids and an existing MMA mouse model. (3) Develop a roadmap to tailor gene-correction therapies to individual patients, using the reporter with the patient mutation and mutational context, patient-derived organoids, and a mutation-specific animal model for a common MMA mutation. This foundational work will lay the basis for broad clinical application of precise gene-editing therapies.

Keywords: gene editing,metabolic disease,liver,organoids
Identifying and interpreting underground conditions in Southern European countries for thermal storage through Aquifer Thermal Energy Storage systems. (ATES-SEUM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands,Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-02
End date: 2026-09-01
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 2
Project status: SIGNED

The ATES-SEUM project addresses knowledge gaps regarding Aquifer Thermal Energy Storage (ATES) systems' viability in Southern European Union Member (SEUM) states. ATES systems store thermal energy in aquifers for building heating and cooling but face challenges like groundwater fluctuations, climate change impacts, and complex legislation. The project aims to develop a common methodology for SEUM countries to evaluate ATES systems' potential, considering the specific impacts of climate change. To achieve its goals, the project works with experts at Delft University of Technology (TUD) and the Geological and Mining Institute of Spain, with knowledge sharing in Italy and Greece. It responds to the need for renewable alternatives to heating and cooling, especially in water-scarce SEUM countries. Challenges include excessive groundwater demands for irrigation, climate change effects, and legislative complexities in SEUM states. Spain is the primary study region, with additional case studies planned in Italy and Greece. Through interdisciplinary research, training, and knowledge dissemination, ATES-SEUM aims to enhance methods and knowledge related to ATES system suitability in water-scarce regions. It aligns with EU sustainability goals and emphasizes the integration of renewables and technologies to reduce energy consumption and emissions. Additionally, it aligns with the EU Water Framework Directive by studying groundwater aquifers' current and future states. The project's objectives include assessing climate change impacts on groundwater, evaluating aquifer suitability, generating suitability maps, and transferring results to influence energy policies and regulations in SEUM states.

Keywords: hydrogeology,climate change,heat pumps,energy policies,geothermal energy
Isotopic Labeling of Biotherapeutics (ISOBIOTICS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France,United Kingdom,Germany,Sweden,Denmark,Portugal,Spain
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-02-01
End date: 2027-01-31
Duration (months): 48.0
Total project cost (EUR): 3178994.4
EU funding (EUR): 2703924.0
Participants: 19
Project status: SIGNED

Biological drugs such as peptides, proteins, oligonucleotides and analogs provide the patients with more efficacious and less toxic treatments and have lower attrition rates than chemical drugs since 1 on 9 new biological entities entering clinical trials reaches the market (1 on 16 for chemical drugs). Consequently, 15 on 24 top blockbuster drugs were biotherapeutics in 2020 (world-market share of about 40% of $175 billion of revenue per year). In order to reduce the immunogenicity of biodrugs, to overcome their fragility and to increase their capacity to reach quickly and massively their target, reduced-size biologics are extensively developed. However, radiolabeling of large molecules by grafting bifunctional chelating agents which do not alter significantly their biological activity is thus no longer possible with smaller biodrugs. It is therefore of paramount importance to devise new radiolabeling approaches carried out on tiny quantities in aqueous media and very soft conditions. It is also crucial to train a new generation of radiochemists in order to implement these methods and to meet the needs of the European industry. ISOBIOTICS ambitions: 1) to develop new chemically-benign strategies for the last-stage radiolabeling of large peptides, small/medium-size proteins, oligonucleotides and analogs with deuterium, tritium and carbon-14 (preclinical and phase 0 clinical evaluation), and fluorine-18 (phase I-III clinical trials); 2) to educate a new generation of young talented PhD students specialized in the radiolabeling of biologics through a combination of interdisciplinary lab research, transdisciplinary and intersectorial secondments, technical taught courses, scientific lectures and complementary skills workshops; 3) to ensure the appropriate dissemination, exploitation and communication of all ISOBIOTICS outputs in order to maximize the project’s impact and radiance; 4) to secure the students employment and the sustainability of training structures.

Keywords: biological drugs,peptide,protein,antibody fragment,oligonucleotide,radiolabeling,deuterium,tritium,carbon 14,fluorine 18,drug innovation,therapeutics,diagnostics,theranostics,imaging