Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
NonEquilibrium MOlecular processes in the ultrastrong coupling regime (NeMo)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,United States
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-05-01
End date: 2029-04-30
Duration (months): 36.0
Total project cost (EUR): 424992.0
EU funding (EUR): 424992.0
Participants: 2
Project status: SIGNED

The manipulation of the electromagnetic environment of molecular systems provides a way to control their properties and dynamics. Specifically, under strong coupling conditions, the formation of hybrid light-matter states delocalized over a large number of molecules has been shown to change the rate of chemical reactions and modify diverse transport phenomena. Despite considerable theoretical and experimental efforts, the ultimate physical mechanism responsible for these effects is not well-understood, mainly because of the complexity of these systems. Molecules present multiple internal degrees of freedom, which makes their theoretical description unmanageable when dealing with macroscopically large ensemble sizes. Besides, the phenomenology when entering the ultrastrong coupling regime is largely unexplored, where new theoretical challenges come into play. The objective of this action is to provide the missing theoretical and computational frameworks to study the dynamics of realistic molecular systems ultrastrongly coupled to a complex electromagnetic environment. Starting from the full multimode cavity QED Hamiltonian, we will first derive the effective model for such physical settings including effects that have been missed so far but are nonetheless important to address the observed (as well as the accessible) phenomenology. Then, we will apply many-body numerical techniques from quantum optics to describe the dynamics of strongly-driven, ultrastrongly-coupled systems. With these tools at hand, we will study nonequilibrium effects in these platforms, specifically energy transport and driven-dissipative phase transitions. The outcomes of this project will thus bring us closer to the definite understanding of the phenomena afforded by molecular strong coupling, and allow us to reliably predict nonequilibrium effects relying on molecular ultrastrong light-matter coupling.

Keywords: cavity qed,polaritonic chemistry,strong coupling,ultrastrong coupling,molecular polaritons,cavity induced mechanisms,energy transfer,plasmonic nanocavities,light matter interactions
Engineered DNA Moiré Superlattices (DMoS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Germany
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2498737.0
EU funding (EUR): 2498737.0
Participants: 1
Project status: SIGNED

Moiré patterns are commonly observed phenomena across all length scales. A moiré pattern arises from the spatial modulation of stacked sublattices, which have slightly different lattice constants and/or orientations. This pattern forms a superlattice with a larger periodicity, spanning multiple unit cells of the sublattices. To date, moiré superlattices comprising sublattices with lattice constants of several nanometers have not been experimentally realized. Moiré superlattices at this length scale do not have counterparts in naturally occurring materials, but represent analogues to twisted van der Waals and twisted nanophotonic systems. This DMoS project aims to underscore a pinnacle in DNA nanotechnology by creating entirely new, artificial moiré superlattices that bridge the gap between the angstrom and submicron length scales. These DNA moiré superlattices with precisely engineered structural features will provide a fertile ground for addressing a fundamental question in nature: ‘How does structure influence function?’ By pushing the boundaries of what is possible in structural control at the nanoscale, DMoS is set to explore the intricate relationship between structure and function in both spintronic and optical systems - fields that require precise manipulation of spin and light. Specifically, DMoS will investigate how the structural features of DNA moiré superlattices influence spin polarization in chirality-induced spin selectivity and explore their structural impact on lattice-dependent optical chirality in moiré chiral metamaterials. This fusion of interdisciplinary expertise opens new frontiers in structural design and functionality, with implications beyond the current state of the art. Ultimately, DMoS aims to transform our understanding of how nanoscale features can be engineered to achieve targeted functionalities, setting the stage for a new generation of nanostructured devices with far-reaching applications in science and technology.
Optimisation of free-form milling with ball-end tools through computational manufacturing (CVISION)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Portugal
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-05-01
End date: 2028-04-30
Duration (months): 24.0
Total project cost (EUR): 191343.12
EU funding (EUR): 191343.12
Participants: 1
Project status: SIGNED

Free-form surfaces are present in key industries such as aerospace, automotive, and energy, fulfilling both aesthetic and functional requirements. Ball-end milling is preferred for manufacturing due to its high efficiency and precision. However, the large number of variables makes the process challenging and not fully understood. The intermittent cutting characteristics, along with changes in tool-workpiece contact and variations in effective cutting speed, are some of the difficult aspects to predict that significantly impact surface quality and part accuracy. Additionally, depending on the tool orientation, the transition between ploughing and shearing as the predominant mechanisms can occur, with the transitional zone not being well understood. This research proposes the development of a robust methodology to integrate predictive mathematical models into commercial CAD/CAM software, enhancing the precision of ball-end milling of free-form geometries. The project will focus on understanding the cutting phenomena, particularly the transition between shearing and ploughing, and implementing cutter workpiece engagement (CWE), and the cutting forces within the CAM software environment for finishing operations with ball-end mills. The expected outcomes include new insights into the milling process, a robust methodology for modelling outputs, and the development of an API capable of predicting machining outcomes. This will provide tools for improving programming efficiency, reducing waste, and aligning with sustainability goals, thereby enhancing the academic understanding of the process and the competitiveness of the industry.

Keywords: ball end milling cad cam api free form modeling and simulation
The evolution and development of mechanochemical patterning systems mediating integumentary appendage emergence (MechChem)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 2
Project status: SIGNED

Biological patterning involves the spatial organisation of cells and tissues from homogenous states into complex forms, and therefore underlies the development of all living systems. Classical research has focused upon chemical (including molecular) patterning processes, such as Turing reaction-diffusion (RD). In such RD systems, interactions of diffusing activatory and inhibitory morphogens produce stable patterns which dictate the spatial organisation of biological structures. Recent work has shown that mechanochemical processes, in which mechanical cues are integrated with chemical signalling, also contribute to patterning. For example, the mechanical contraction of dermal cells triggers chemical RD patterning of feathers in the chicken. The discovery of mechanochemical processes has constituted a paradigm shift in our knowledge of pattern formation. However, to go beyond the state-of-the-art and obtain a comprehensive evolutionary and developmental understanding of mechanochemical patterning, we must examine these systems in evolutionarily diverse species. MechChem will examine the mechanochemical patterning of denticles (or scales) in the embryonic shark. As sharks belong to an early-diverging vertebrate lineage (the cartilaginous fishes), they occupy the sister lineage of bony vertebrates. Previously, I revealed broad conservation of chemical RD dynamics between both denticle and feather patterning. However, integrated mechanochemical systems in the shark remain unexplored. Using state-of-the-art techniques in fluorescent imaging and biophysical analysis, MechChem will characterise and manipulate mechanical elements of denticle development, to elucidate the roles of mechanochemical patterning. Results will be compared to published work regarding feather patterning and new data concerning avian scale patterning, yielding important evolutionary conclusions regarding the role of mechanochemical systems in mediating biological patterning across the vertebrates.

Keywords: evolutionary developmental biology,pattern formation,integumentary appendages,mechanochemical patterning,mechanobiology
Bio-HhOST Project in the ELMs Portfolio (Bio-HhOST in ELM)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: other EIC
Destination: Other destinations
Action type: Coordination and support actions
Countries involved: Italy,United Kingdom,Switzerland,Germany,France
Call: EIC Booster grant for EIC Pathfinder and EIC Transition grants (HORIZON-EIC-2024-BOOSTER-IBA-01, 2024)
Start date: 2024-11-01
End date: 2027-10-31
Duration (months): 36.0
Total project cost (EUR): 57007.32
EU funding (EUR): 49828.75
Participants: 5
Project status: SIGNED

The Bio-HhOST project (bio-hybrid hierarchical organoid-synthetic tissue) deals with the creation of bio-hybrid materials that comprise living & artificial cells, in dynamic communication, such that artificial cells may influence the proliferation, differentiation and function of living cells. In this way the project fits perfectly into the EIC Engineered Living Materials (ELMs) Initiative. This makes Bio-HhOST the ideal candidate to engage with the ELMs portfolio reinforcing its coordination and management through the collaboration in reaching the EMLs portfolio objectives by an active involvement in its main governing body and Working Groups. Bio-HhOST will also help re-evaluate and update the objectives of the Portfolio by widening the fields of bio-printing, organoid development and tumor targeted therapies. We are applying to enter this Initiative to exploit our EIC Pathfinder project results, navigate pathways to commercialization, and impact the future of innovative reseaThe Bio-HhOST project (bio-hybrid hierarchical organoid-synthetic tissue) deals with the creation of bio-hybrid materials that comprise living & artificial cells, in dynamic communication, such that artificial cells may influence the proliferation, differentiation and function of living cells. In this way the project fits perfectly into the EIC Engineered Living Materials (ELMs) Initiative. This makes Bio-HhOST the ideal candidate to engage with the ELMs portfolio reinforcing its coordination and management through the collaboration in reaching the EMLs portfolio objectives by an active involvement in its main governing body and Working Groups. Bio-HhOST will also help re-evaluate and update the objectives of the Portfolio by widening the fields of bio-printing, organoid development and tumor targeted therapies. We are applying to enter this Initiative to exploit our EIC Pathfinder project results, navigate pathways to commercialization, and impact the future of innovative research in Europe.

Keywords: bio hybrid tissue,organoids,mammalian cells,artificial cells
Microplastic contamination in agricultural soil ecosystems and the effect on soil and plant health (MiCoS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems E ngineering
Panel description: Biotechnology using all organisms , biotechnology for environment  and food applications, applied plant and animal sciences , bioengineering and synthetic biology , biomass and biofuels , biohazards
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1498813.0
EU funding (EUR): 1498813.0
Participants: 2
Project status: SIGNED

Plastics are found in nearly every environment and disrupt key ecosystem services. While the effect of plastic in marine and freshwater ecosystems has been studied extensively, effects of plastic on soil ecosystem functions such as plant growth, microbial biomass and water permeability have been mostly overlooked, particularly for the smallest particles, the microplastics (MPs; ≤ 5 mm). The lack of appropriate techniques and methodologies for sampling, extraction and detection hamper the research concerning MP distribution in soil ecosystems. This research gap has led to fragmentary knowledge and even contradictory results in MP studies on soil ecosystems, as different concentrations, sizes, shapes and MP polymer types were considered. Therefore fundamental insights in the role of MPs on soil and plant health are missing. We will advance the field by working in a three step approach to mechanistically define how MP pollution outbalances the soil (and plant) ecosystem. First, the risk of MP pollution in soil will be assessed by correlating MP concentrations of 240 soils with soil health indicators. To measure the MP concentration, a fast, cost-effective and standardized method to detect, identify and quantify MPs (≥ 1 µm) in soils will be developed. Second, these correlations between MPs and the soil health indicators will be validated and tested in greenhouse experiments, to understand the biological underpinnings that drive these correlations. MP induced changes in plant growth, plant disease susceptibility, soil texture, soil chemical composition and the microbial community will be studied. Third, to reduce the risk (introduction and accumulation) of MPs in soil ecosystems, we will actively search for biodegrading organisms making use of a novel sequencing approach. With this multidisciplinary approach, we will be able to mechanistically define the effects of MPs on soil and plant health and advance the field by identifying plastic-biodegrading microorganisms.

Keywords: microplastics,soil health,plant development,dna stable isotope probing,statistical modelling
Real-Time high-content Super-Resolution Imaging of ES Cell States (RT-SuperES)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel,France,Germany,Portugal
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-07-01
End date: 2027-06-30
Duration (months): 48.0
Total project cost (EUR): 3488483.13
EU funding (EUR): 3488483.0
Participants: 10
Project status: SIGNED

The development of super-resolution (SR) microscopy in recent years has revolutionized cell biology, breaking the diffraction limit of light microscopy by order of magnitude. However, SR is currently incompatible with high-content imaging. RT-SuperES will provide a groundbreaking and affordable technology with automated SR capabilities beyond the state-of-the-art. To this end, we will generate a library of endogenously-labelled SNAP-tag fusion proteins in mouse embryonic stem cells (ESCs), and deploy a real-time decision-making module, which will continuously monitor our SNAP-tagged cells using fast fluorescence imaging, and, once a change is detected, will fix the desired cells, and switch to SR mode. By bringing together seven world-leading experts from four different countries, combining basic and applied research and industry, we propose several firsts: a) The first endogenously-labelled clone library of SNAP-tag fusion proteins; b) Utilize machine learning (ML) for real-time automated decision making, autonomously switching from fast conventional to SR imaging; c) Combine high content with SR imaging; d) Integrate novel, cutting-edge technologies, namely SR Radial Fluctuations (SRRF), NanoJ-Fluidics, Single Molecule Localization Microscopy (SMLM) and Structured Illumination Microscopy (SIM); e) Collect large scale imaging datasets of cell states in ESCs, and f) Provide cell-cycle stage-dependent nanoscale localization of selected nuclear and chromatin proteins (e.g. H3.3), during early ESC differentiation. RT-SuperES will provide the scientific community with the first-of-its-kind commercial real-time SR-highcontent imaging system, and the first library of endogenously SNAP-tagged ESC clones, which are ideal, among many other things, for SR imaging.

Keywords: super resolution high content stem cells machine learning microscopy robotics artificial intelligence pluripotent stem cells
LIACFLASH: a life changing IOeRT technology for oncology care (LIAC FLASH)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-12-01
End date: 2025-05-31
Duration (months): 30.0
Total project cost (EUR): 3571375.0
EU funding (EUR): 2499962.5
Participants: 1
Project status: CLOSED

Radiation Therapy is, along with surgery, the most effective therapeutic approach for the treatment of solid tumours. Unfortunately, biological effects of radiation dose to healthy organs at risk (often surrounding targeted tumour mass) represent a major dose-limiting constraint in Radiation Therapy. This implies that tumours cannot be always successfully treated, as delivered dose might not be enough for an effective treatment, decreasing survival of these cancer patients. LIACFLASH is an IOeRT system for cancer treatment built on a breakthrough scientific discovery: the FLASH effect, which enables delivery of high radiation dose with significantly reduced associated radiocytotoxicity, while achieving efficient tumour killing, widening the therapeutic window.

Keywords: flash radiotherapy,radiocitotoxicity,therapeutic window,solid tumours,surgery,ioert,cancer treatment,medical linear accelerator
PHOTOelectrocatalytic systems for Solar fuels energy INTegration into the industry with local resources (PHOTOSINT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Spain,Slovenia,Italy,Greece,Estonia,Romania,Sweden,France
Call: Direct renewable energy integration into process energy demands of the chemical industry (HORIZON-CL5-2022-D3-02, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 4993752.51
EU funding (EUR): 4993752.5
Participants: 17
Project status: SIGNED

The PHOTOSINT project presents solutions to the challenges chemical industries are facing in integrating renewable energy sources into their processes. The project will deliver sustainable processes to produce hydrogen and methanol as energy vectors using only sunlight as an energy source and wastewater and CO2 as feedstocks, making the industries more auto-sufficient. The pathway is based on solar-driven artificial photosynthesis, and aims to develop new catalytic earth-abundant materials and modifications of existing ones to improve catalytic processes. Design parameters of the PEC cell will be tuned to maximize solar to fuel (STF) efficiency. Moreover to improve the conversion for industrial implementation, PHOTOSINT will develop a novel way to concentrate and illuminate the semiconductor surface to maximize overall energy efficiency. Perovskite solar PV cells will be integrated to harvest the light to supply the external electrical voltage. PHOTOSINT is an ambitious project due to precedents in research conducted to date and the low production rate of the desired products. For integrating sunlight energy into the industry, the catalyst will be studied, and then the best one/s will be implemented in prototypes. The obtained results will be used for making scale-up in pilots with tandem PEC cells. These steps are necessary to assess the industrial scale-up feasibility, promoting the increased competitiveness of renewable process energy technologies and energy independence. MeOH and H2 will be tested in engines. Also, an HTPEM fuel cell will be used for electricity generation, and hydrogen will be tested as an alternative fuel for energy generation instead natural gas in melting furnaces avoiding CO2 emissions.

Keywords: solar fuels co2 reduction water oxidation artificial photosynthesis,hydrogen methanol energy security energy supply,catalyst process design