Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
IDENTITY COMPRESSION: a fundamental breakthrough in social identity, social information, and social polarization (ID-COMPRESSION)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Ireland
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1999980.0
EU funding (EUR): 1999980.0
Participants: 1
Project status: SIGNED

The breakthrough to be pursued in ID-COMPRESSION is that social polarization is information compressibility, where attitudes provide redundant information about group membership. ID-COMPRESSION proposes that a polarized social information system is a socially comprehensible one, where it is easy to categorize people into groups and identify social outliers. Since comprehensibility depends on regularities, this will consequently be a compressible social information system. If successful, this radical theory of social normativity will explain how: (1) social identity becomes embedded in social information via social interaction; (2) information thereby becomes comprehensible in social identity terms; (3) comprehensibility of identity-laden social information is a form of information compressibility; (4) compressibility facilitates group processes, making positions comprehensible and socially meaningful; (5) the structure of the social information system provides conversion pathways, where (a) the probability of someone taking a new position depends on the ones they already hold, (b) taking a new position shifts the holder’s identity and makes a new range of positions accessible, (c) chains of transition probabilities form pathways through the identity-information space, and (d) the structured social information system is dynamically constituted by the positions expressed by the people within it. (6) Compressible social information systems are ripe for pernicious polarization, particularly in situations of intergroup threat, affective polarization, or zero-sum outcomes. (7) Social media interlocks with psychosocial processes in ways that can accelerate pernicious polarization. This radical new understanding of social normativity will show how social identity dynamically interfaces with social information, allowing us to understand how important social issues (e.g. climate change; global health crises) become identity-charged and polarized.

Keywords: polarization information theory compression social identity social psychology comprehensibility
Forum for Emerging Enabling Technologies in Support to the Digital and Green Transitions through Value Sensitive Innovations (FORGING)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Coordination and support actions
Countries involved: Portugal,France,Italy,Spain,Finland
Call: Academia-Industry Forum on Emerging Enabling Technologies (CSA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 2494092.5
EU funding (EUR): 2494092.5
Participants: 6
Project status: SIGNED

Technological breakthroughs empowered by enabling technologies hold a transformation potential that can be funneled to address industrial and societal grand challenges, like greening and digitalisation. To exploit this transformative potential, the innovation journey that leads new emerging technologies to their market-uptake shall embed since its early value-sensitive considerations, such as environmental and societal implications. With FORGING we propose a new methodology based on a value-sensitive innovation journey that breaks linear innovation trajectories to stimulate new technological visions and pathways attentive to the environment and society, and human-centred in alignment with Industry 5.0. technological frameworks. The value-sensitive innovation journey will be deployed in three phases: the technological uncovering with tech experts from academia and industry to detect early signals of emerging technologies; the societal confluence exploring the desirability and societal impact, and implications of novel technologies; the full-fledged co-creation opening to the broader community to develop concrete use cases for tech uptake. We will develop 6 Technological Pathways to transfer ideas and help industry navigate through issues related to the absorption and deployment of the use cases. FORGING methodology will be implemented by catalysing stakeholders’ community with 600 active members, from academia to industry, to CSS, to policy makers and to the broader society. We aim to organise 24 co-creation sessions, consultations with 20 policy bodies, 6 scenario workshops and Tech. and Innovation campaigns to drive tech. adoption. The FORGING Playbook and Toolbox will gather a set of facilitation guidance and materials for exploration, reflection, co-creation and evaluation of emerging technologies. These assets, jointly with the FORGING community, will sustain FORGING as a new flagship initiative on emerging enabling technologies.

Keywords: value sensitive innovation,design research,horizon scanning,future scenarios,co creation,rri,participatory research
INTEGRATED, CIRCULAR, AND DIGITALLY SUPPORTED SUSTAINABLE SOLUTIONS FOR WASTE MINIMIZATION AND CARBON CAPTURE IN BUILDINGS AND THE CONSTRUCTION SECTOR (WOODCIRCLES)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Circular economy and bioeconomy sectors
Action type: Innovation actions
Countries involved: Denmark,Netherlands,Italy,Estonia,Austria,United Kingdom,Finland,Romania,Spain,Sweden
Call: Integrated solutions for circularity in buildings and the construction sector (HORIZON-CL6-2022-CIRCBIO-02-two-stage, 2022)
Start date: 2023-06-01
End date: 2027-05-31
Duration (months): 48.0
Total project cost (EUR): 7056273.56
EU funding (EUR): 6295867.75
Participants: 23
Project status: SIGNED

The construction sector is responsible for over 35% of the EU’s total waste generation, and accounts for about 50% of all extracted resources and an estimated at 5-12% of total GHG emissions. WOODCIRCLES will contribute significantly to decreasing these numbers by developing innovative circular solutions for sustainable wood construction to help reduce Europe’s dependence on non-renewable resources, cut GHG emissions, reduce waste generation, and offer long-term carbon sinks and substitution of fossil-based and carbon-intensive products. WOODCIRCLES will combine the considerable innovation power of the expert consortium consisting of key stakeholders from all parts of the value chain to release the full circular and sustainable potential of wood construction. Based on identified needs and market potentials, the consortium will develop new value-added value chains for upcycling of wood waste materials and optimized design-for-disassembly building system solutions to significantly increase recycling rates of wood in construction. An ‘Urban Sawmill’ sorting and production facility capable of turning in-homogenous low value wood construction waste into a standardized homogenous value-added, cost-effective baseline product, will be prototyped. WOODCIRCLES will integrate digital tools and solutions in all developments and create digital twins for the large-scale, real-life demonstrators – the Urban Sawmill and the building system prototypes to demonstrate the benefits of digital technology for circular construction. Active involvement of partner cities and their building ecosystems through technical and thematic co-engagement activities will increase deployment. All developed materials, components and system prototypes will be demonstrated, piloted and fully documented – including sustainability assessment – for immediate market uptake. Based on developments, recommendations for new or updated European harmonised technical specifications and Eurocodes will be provided.

Keywords: digitalization for design and construction,renewable construction materials,design for manufacture and disassembly
DigitAl, technologIcal and Social innovation mixes enabling transformation for biodiversity and equitY (DAISY)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: United Kingdom,Hungary,Lithuania,Germany,Greece,Netherlands
Call: Transformative action of policy mixes, governance and digitalisation addressing biodiversity loss (HORIZON-CL6-2024-BIODIV-01, 2024)
Start date: 2025-01-01
End date: 2027-12-31
Duration (months): 36.0
Total project cost (EUR): 2044085.0
EU funding (EUR): 2044085.0
Participants: 9
Project status: SIGNED

DAISY (DigitAl, technologIcal and Social innovation mixes enabling transformation for biodiversity and equitY) aims to understand how interventions (innovations, regulations, financial incentives and tools affecting social norms and emotions) and their mixes can drive systemic change and transformation for biodiversity and equity, offering concrete policy recommendations. For this, DAISY will 1) Investigate processes supporting current innovations and identify emerging ones in key domains of agri-food, energy, education and urban and regional development; 2) Develop, test and provide intervention mixes for transformative change across practical, political and personal spheres, and 3) Engage and enhance the response-ability of civil society, policymakers, and businesses to implement and amplify transformative action. To achieve these goals, DAISY will analyse social, economic, and political processes, map existing innovations, assess their transformative potential, and develop, test and assess interventions to be taken up by policies to address biodiversity loss and equity. DAISY will conduct case studies (spanning from using digital apps through commons governance to degrowth models), workshops, and (social science) experiments, working collaboratively with a range of participants. The project will provide recommendations to decision-makers and build capacity among stakeholders. Additionally, it will foster collaboration with key networks and across a range of domains to amplify its impact.

Keywords: biodiversity transformative equity digital technological social economic innovation policy intervention mixes response ability amplification transdisciplinary
Secure Hardware with AdvaNced NONvolatile memories (SHANNON)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-11-01
End date: 2024-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Over the recent years, the explosive growth of digital technologies allowed to implement disruptive business models driven by data collection and processing. In particular, the internet of things (IoT) opens unprecedented opportunities for consumers (smart society), organisations/companies (industry 4.0/ smart factories) and governments (smart nations). However, as every adoption of new technologies involves some risks, security attacks are amongst the most severe challenges for IoT: only in 2021, the inflicted damages have been valued $6 trillion globally and 1,097 organizations were hit by ransomware attacks. Secure IoT is generally enabled by the physical unclonable function (PUF), namely a hardware function which is embedded in the chip and capable of generating a random, unique response to a given challenge. Improvements in attack methods over the years have recently moved the field of PUFs from the conventional, silicon-based CMOS technology, toward emerging non-volatile memories (NVMs). The latter allows for high density, low cost, highly scalable PUF with the capability of reconfiguration. Currently a truly tamper-resistant and reliable weak PUF leveraging stochastic switching of NVMs for secure IoT is still missing and highly requested by the market. Within the ERC-COG project RESCUE (2015-2020), a novel method for true random number generation (TRNG) based on NVMs was developed and patented. The TRNG scheme allows for iPUF (invisible PUF), namely a digital, highly reliable PUF, which is 100% robust to physical attacks. Within the SHANNON project, we will address the technical and commercial feasibility of iPUF, validating the concept with industry grade embedded NVMs and elevating its technology readiness level via experimental tests and simulations. New architecture and algorithms will be developed to strengthen the IP position of iPUF as a scalable security primitive for IoT systems.
Identifying principles and mechanisms of cell cycle control in Bacteroides species. (BACPRO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 200400.0
EU funding (EUR): 200400.0
Participants: 1
Project status: SIGNED

The gut hosts a complex community of bacteria, archaea, and viruses, which together play a key role in shaping human health. The microbiome has featured in extensive metagenomic studies, uncovering tremendous diversity. However, there is remarkably little research on the cell biology of the microbiome’s constituent members. Among the most influential members of the gut microbiome is the genus Bacteroides, which has been implicated in digesting complex carbohydrates, maturation and regulation of the immune system, and regulating intestinal neurotransmitters. There is also significant interest in engineering Bacteroides spp. as promising candidates for diagnostic and therapeutic purposes. Despite their clear relevance for human health, we lack knowledge on fundamental aspects of Bacteroides proliferation (i.e., their cellular organisation, mechanisms underlying their growth, cell division, DNA replication, or their growth preferences). Such information is essential and represents previously unexplored bacterial cell biology, given Bacteroides must adapt to an incredibly transient environment that shifts rapidly from feast to famine while contending with a constant stream of variable stressors. This project seeks to advance our knowledge of Bacteroides spp. by examining intraspecific diversity, utilising tractable Bacteroides strains, and leveraging the Gover’s lab high-throughput single cell phenomics (HTSCP) methodology. I hypothesise that Bacteroides spp. utilise simple rules of cell cycle control, similar to those recently identified in Escherichia coli by Govers et al., to ensure robust cellular replication across many conditions. Such unifying principles integrate cell cycle and growth rate with cell size, while enabling plasticity, allowing cells to respond to their environments. Understanding these rules and identifying their underlying mechanisms will provide indispensable information for furthering studies of the Bacteroides and developing their utility.

Keywords: anaerobic bacteria,cell cycle dynamics,high throughput single cell phenotyping
Illuminating Charge Transport in Feldspar to Measure Rates of Earth Surface Processes (LUMIN)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Denmark
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2998010.0
EU funding (EUR): 2998010.0
Participants: 1
Project status: SIGNED

LUMIN will enable unprecedented quantitative measurements of rates of Earth surface processes, through a new understanding of the charge transfer that records these rates in natural minerals. Earth surface processes sculpt landscapes, disperse nutrients and affect climates and ecosystems; knowledge of the rates of these processes is fundamental to understanding and predicting landscape evolution. Quantifying such rates has proven very challenging over 0.0001-100 m spatial and 10-100,000 year temporal scales. Recently, luminescence dating techniques based on feldspar, the most dominant mineral in Earth’s crust, have shown a unique potential to quantify rates over such scales. These techniques rely on mathematical models of charge transport in feldspar when exposed to ionising radiation, heat and light in Earth surface environments. However, despite extensive efforts, our models yield inconsistent results, and remain controversial because of our inability to observe these charge transfer processes. The prime objective of LUMIN is to close this acute knowledge gap by applying novel innovations in luminescence physics. Using our recent breakthrough discovery which enables imaging of trapped electrons, LUMIN will for the first time: a) observe the spatial and temporal evolution of atomic states participating in luminescence, b) develop a unified mathematical model of charge transport in feldspar from first principles, and c) validate this model for measuring rates of Earth surface processes. LUMIN will provide a paradigm shift in our knowledge of charge transport processes in feldspar, and thus enable quantification of mass removal and transport on unprecedented spatial and temporal scales. Such data are essential for i) resolving the roles of climate, tectonics, and anthropogenic forcing in shaping our landscapes, and ii) further developing and field-testing landscape evolution models for assessing and addressing the challenge of global warming.

Keywords: luminescence geochronology,mineral physics
Ruthenium Peptide Bioconjugates for Photoactivated Chemotherapy (pepRu4PACT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 1
Project status: CLOSED

One of the most severe limitations of current anticancer chemotherapy are the serious side effects caused by toxic drugs affecting not only tumors but also healthy organs. Local activation of drugs by light irradiation of the tumor is a promising approach to control where the toxicity is delivered. Metal complexes are well suited for photoactivated chemotherapy, but their activation wavelength is often too low to afford high tissue penetration of light; also, their ability to enter cancer cells is often controlled by lipophilicity tuning, which is unselective; finally, their phototoxicity often relies on oxygen-dependent mechanisms, while many tumor tissues show low dioxygen concentrations. The aim of this proposal is to develop new metallodrugs that are activated by red or near-infrared light, enter cells by controlled mechanisms, and deliver strong phototoxicity to cancer cells also under low oxygen conditions. The design is based on connecting multiple Ru(II) metal complexes to a biologically active antitumoral peptide. The ruthenium complexes will have a tuned coordination environment to allow red/near-IR light activation; meanwhile, the peptides will rely on methionine residues to coordinate ruthenium, and allow controlled cellular uptake of the prodrug into cancer cells. Both components will cage each other in the dark, thus affording low toxicity; while light-induced cleavage of the ruthenium-thioether bonds will release two bioactive components, which will kill cancer cells. The novelty of this proposal is to combine metal-based photoactivated chemotherapy with therapeutic peptides to enhance phototoxicity by creating synergies between both photoproducts. By combining light activation, resulting in timely- and spatially-resolved toxicity release, and bioactive peptides, which will improve uptake in cancer cells, this project will deliver new fundamental knowledge on the interaction between peptides and metals, and between metallopeptides and cells.

Keywords: chemotherapy,photoactivated chemotherapy,bioconjugate,phototherapy,ruthenium,metallodrug,cancer
DESIGNED ADENOVIRUS VECTORS FOR CELL-SPECIFIC DELIVERY OF GENOME EDITING TOOLS (iAds Hop-On)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: France,Lithuania
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 24.0
Total project cost (EUR): 516370.0
EU funding (EUR): 516369.5
Participants: 2
Project status: CLOSED

The discovery of CRISPR/Cas systems provides new opportunities to treat human disorders at the genome level, including neuropathologies, which have an immense and still increasing burden on our society. However, the advancement of gene editing therapies for human disease has been lagging behind the development of relevant molecular tools, in part, due to the lack of suitable delivery vectors for CRISPR/Cas systems in vivo. The development of intelligently designed adenovirus vectors opens new avenues for the delivery of state-of-the-art genome editing tools into the tissue of interest to revert disease-causing gene mutations. Therefore, this Hop-On project aims to join the iAds consortium that develops improved vectors for clinical gene transfer and to contribute to its aims by developing clinically relevant test of iAds vectors using human tissue and incorporating genome editing tools in vectors targeting the heart and brain. The introduction of the widening partner will complement the existing expertise of the iAds consortium and provide critical support for the optimization of AdV vectors suitable for gene transfer in humans. Through seamless integration into the project, the widening partner will immediately contribute to the characterization iAd vectors in the context of the brain tissue, thus providing essential information on iAds tropism and innate immune responses in situ. Such results will provide critical information for the development of therapeutic vectors for clinical use, ensuring the translatability of novel vectors developed in iAds to human applications. Proof-of-concept delivery of genome editing tools with helper-dependent vectors will pave the path to address unmet needs to bring the advances of CRISPR/Cas molecular tools to clinical development.

Keywords: crsipr cas,organotypic brain slices,brain organotypic cultures,adenoviral vectors,gene editing,postsurgical tissu