Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
European innovation partnership network promoting operational groups dedicated to forestry and agroforestry (FOREST4EU)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Innovative governance, environmental observations and digital solutions in support of the Green Deal
Action type: Coordination and support actions
Countries involved: Italy,Spain,Finland,Germany,Slovenia,France,Portugal,Latvia,Croatia
Call: Broaden EIP Operational Group outcomes across borders by means of thematic networks, compiling and sharing knowledge ready for practice (HORIZON-CL6-2022-GOVERNANCE-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 2006668.75
EU funding (EUR): 2006668.5
Participants: 17
Project status: SIGNED

Innovation is a key priority for the private forestry(F) and agroforestry (AF) sector, and nationally/locally funded EIP-AGRI Operational Groups (OGs) can play a key role in driving innovation at the EU level. However, the results of the OGs in F and AF have not been disseminated to all EU countries because the various local/national OGs have not been linked to the experiences of other countries and the knowledge generated has only been shared locally. In order to disseminate the knowledge generated by the OGs in F and AF to all EU regions, FOREST4EU will set up multi-actor innovation interregional transversal Hubs dealing with 5 innovation topics ('Wood mobilisation', 'Forest adaptation to climate change', 'Improving approaches, models and tools for sustainable forest management and ecosystem service provision to improve economic, environmental and social benefits for rural areas', 'non-wood forest products', 'Agroforestry') to facilitate interregional transfer of knowledge generated by the OGs. FOREST4EU will collect, share and disseminate knowledge related to innovations from F and AF OGs. This will be done by providing tailored and understandable dissemination materials accessible through existing platforms, as well as capacity building materials developed according to identified regional needs and transferred to where the innovation can be applied. FOREST4EU will also discuss and present the benefits of OGs relevant to the Green Deal to EU policy makers. In addition, FOREST4EU will establish connections with policy makers working with CAP and innovation at the local level, particularly in countries where OGs dealing with F and AF are not funded, to promote new initiatives and a greater geographic balance between different EU regions.

Keywords: forest,agroforestry,eip agri operational groups,innovation,digitalization,wood mobilisation,forest adaptation to climate change,forest management,ecosystem services,non wood forest product
Interplay between energy and metabolism in dictating growth constrain and setting final size (SizeGrowth)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

What determines organ and organism size is a fundamental question that remains unanswered. All through development, organ size increases while being scaled to organism size, until growth terminates. This project addresses the question of how growth is regulated and arrests during development. We propose that energy becomes limiting throughout development and thus sets final size. Indeed, Kleiber's law postulates that the cellular metabolic power decreases with increasing organism mass, limiting the energy assigned for growth. Using Drosphila melanogaster as a model organism, we aim to study growth directly as a 3D dynamic process in order to address the question of how organs and organisms form with consistent size and shape. We will track organism growth in terms of mass and volume as well as organ growth during the larval period of development. By correlating size increase to energy fluctuations, we will uncover to what extent fly larvae follow Kleiber’s law and whether individual organs also follow the same rule. Finally, we will consider three pillars that restrict growth capacity of organs by constraining energy: fractal transportation (branching), morphogenetic gradients and mechanics, and demonstrate how growth arrests during development.

Keywords: size,growth,energy,metabolism
Optical formation of ground state ultracold tetratomic molecules (UltracoldTetramers)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Poland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-07
End date: 2027-04-06
Duration (months): 24.0
Total project cost (EUR): 179006.16
EU funding (EUR): 179006.16
Participants: 1
Project status: TERMINATED

There is currently growing interest in forming ultracold polyatomic molecules. It is anticipated that their rich internal structure will provide powerful platforms for quantum information processing, precision measurements, studies in cold-controlled chemistry, and simulation of quantum many-body systems. In a recent ground-breaking experiment, weakly bound ultracold tetratomic molecules (“tetramers”) have been realized from pairs of ultracold alkali-metal diatoms using external fields [Nature, 626, 283 (2024)]. It also opened a new question on how such weakly bound tetramers can be transferred to their absolute ground state. The main challenge is to mitigate their collisional loss from experimental traps which is expected to be very high due to an immense number of internal degrees of freedom. In this Action, I will propose novel theoretical methods to transfer weakly bound ultracold tetramers to deeply bound states in their ground electronic potential using lasers. To achieve this goal, I will combine two well-established methods for ultracold diatomic molecules: (a) Collisional shielding of molecules against inelastic and reactive loss, and (b) Stimulated Raman Adiabatic Passage (STIRAP) method for transferring weakly bound ultracold molecules to their ground vibronic state. I will implement the method (a) for molecules colliding in an excited electronic state required for STIRAP. I will develop a new method (b) which will enable the creation of deeply bound ultracold tetramers. Successful implementation of this project will create a new indirect method of creating ultracold polyatomic molecules in deeply bound states. The proposed method is near-universal and can be applied to a wide range of molecules. Stable gases of such molecules will allow the creation of a new type of Bose-Einstein Condensate made of polyatomic molecules. This Action will enable me to expand my skillsets in cutting-edge ultracold research and will help to launch my independent career.

Keywords: ultracold molecules,ultracold collisions,stirap,photoassociation,ultracold shielding
Innovative, minimally invasive Medical Prostatic Retraction Device for the treatment of Benign Prostatic Hyperplasia (BPH) Patients in the office settings. (MPRD)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Israel
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 4823931.25
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Butterfly Medical, a medical-device start-up, is developing a fast, simple, and minimally invasive alternative treatment to medication and surgery used for Benign Prostate Hyperplasia (BPH) treatment. Butterfly’s innovative device transfers the procedure from the operating room to the clinic, with the device being placed in 6 to 8 minutes, in doctor’s office, under local anaesthesia. Butterfly’s unique anatomically shaped proprietary nitinol implant is positioned in the prostatic urethra in order to open the urine path in the prostate for improved urine flow thereby relieving BPH symptoms. Implant doesn’t require any resection, cutting, or ablation of prostatic tissue. FIH clinical trials involving 85 patients performed in leading medical centres in Israel show a high degree of safety and effectiveness. Through this EIC project, Butterfly will undertake post-marketing studies in leading medical centres in Europe, and pivotal FDA study in the US.

Keywords: benign prostatic hyperplasia bph,acute urinary retention,urethral implantation,mists,turp,urination,prostate surgery,bph implant,minimally invasive device
FAST ANTIBIOGRAMS FOR EARLIEST DETERMINATION OF THE RIGHT ANTIMICROBIAL TREATMENT (MICAST)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: France
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 24.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Antimicrobial resistance (AMR) is a silent pandemic that is causing over 1.2 million deaths each year worldwide. The World Health Organization predicts this number to rise to 10 million per year by 2050. If not stopped, AMR will create an era of health uncertainty where infections can no longer be treated with humanity’s precious heritage of existing drugs. The medical need to detect AMR at the earliest is huge: saving time to identify AMR means saving lives in the short-term and avoiding follow-up issues. In this context, MOLSID is developing MICAST, a next-generation Antibiotic Susceptibility Test (AST) that drastically speeds up currently employed ASTs based on diffusion disks or strips, the global gold standard. Time-to-result thus shortens from 16-24 hours to only 4 hours. Prior to MICAST, all innovation proposed these past 20 years turned out to be only incremental, gaining a few minutes of time-to-result over the gold standard. MICAST delivers the information on the appropriate antibiotic so fast that the patient’s survival prospects are significantly improved. Its contribution to avoiding the misuse of antibiotic molecules will prove equally important. MICAST makes use of MOLSID’s fluorescence-generating molecular probe, a chemical reactant protected by 5 international patents. The probe’s performance distinguishes itself by staining growing bacteria and by retaining the signal at the site of the growing colony. These features allow for continuous measurement and the earliest determination of result. MOLSID now needs to automatize MICAST to allow for high-throughput operation, for scale-up to industrial production levels, for its validation in a large-scale, multicenter, prospective clinical study, and for regulatory approval. With MICAST, MOLSID addresses the global market of AST (€1.4bn in 2021) that is rapidly growing (CAGR >6%). MOLSID will create a “blue-ocean” market of fast AST, a market and an approach only MOLSID can claim to date.

Keywords: global health solution,live saving antibiograms,right treatment in time,antimicrobial resistance,amr,rapid antimicrobial susceptibility testing,ast,biomed,fast diagnostics,rapid dx tests
3D-assembly of interactive microgels to grow in vitro vascularized, structured, and beating human cardiac tissues in high-throughput (Heartbeat)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-10-01
End date: 2029-03-31
Duration (months): 78.0
Total project cost (EUR): 2969219.0
EU funding (EUR): 2969219.0
Participants: 3
Project status: SIGNED

Generating 3D in vitro functional tissues and organs in the millimeter scale remains an unmet dream of modern medicine. Irrespective of great efforts in the field of tissue engineering to design injectable/pipettable hydrogels or implantable/non-pipettable scaffolds for 3D cell growth, it is not yet possible to generate functional and personalized tissues with native-like structures and mature blood vessels. The main reason for this limitation is that current materials do not recapitulate the complexity and dynamics of the native cell environment. To create personalized human tissues, patient-derived induced pluripotent stem cells can differentiate in any cell type but controlling stem cell expansion, differentiation, and organization inside the same 3D scaffold is not possible up to now, as it requires biomimetic and interactive materials beyond simple hydrogels. HEARTBEAT will break with traditional ways to make 3D biomaterials by assembling and crosslinking a variety of unique pre-programmed, rod-shaped, and interactive microgels instead of molecular building blocks. The main aim is to achieve macroporous, aligned, actuatable, and on-demand degradable constructs after automatically pipetting/mixing different microgels and cells, which is not possible with conventional hydrogels. A compatible high-throughput system will be used to screen the innumerable combinations of design parameters to systematically study (stem)cell-material and cell-cell interactions to grow complex tissue. In HEARTBEAT, I will focus on using the interactive bottom-up microgel assemblies to generate millimeter-scale vascularized beating heart tissues. The project will elucidate how material properties, architectures, and actuation affect human heart tissue formation and vascularization and how the construct has to adapt to the growing tissue over time to provide the right extracellular environment.

Keywords: microgels,cardiac tissue,induced pluripotent stem cells,vasculogenesis,hydrogels,tissue engineering,in vitro tissue models,high throughput screening,hts
Loam Walls with Algorithmically Generated 3D Natural Reinforcement (AlgoLoam)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Germany,Netherlands,Austria,Sweden,Serbia
Call: EIC Pathfinder Challenge: AEC digitalisation for a new triad of design, fabrication, and materials (HORIZON-EIC-2023-PATHFINDERCHALLENGES-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 4532625.0
EU funding (EUR): 4532625.0
Participants: 10
Project status: SIGNED

We aim to develop Loam Walls with Algorithmically generated 3d Natural Fibre Reinforcement (AlgoLoam), as the first completely biodegradable, made of exclusively natural materials, self-supporting reinforced light loam wall solution, totally or partially prefabricated. AlgoLoam will be developed by an interdisciplinary team of architects, material scientists, textile technology experts, biomimetics experts, sustainability experts, mechanical engineers, loam/clay product developers and programmers, through collaborative, iterative processes to create critical interactions between disciplines. We will explore the applicability and limitations of using exclusively natural and sustainable, CO2 negative, materials to create a wall solution with multiple applications in architecture and interior design with the potential to reduce relative and absolute contributions of greenhouse gas emissions embodied in new buildings. The natural 3D reinforcement embedded in the wall elements will act as a biomimetic/ textile inspired skeleton, making the wall solution a symbiotic, mutually interdependent and enabling natural composite material system. Optimal usage of materials and improved mechanical properties and load-bearing capabilities of the loam volume will be ensured by applying topology optimisation and through algorithmic and parametric variation of the natural composite. AlgoLoam will be optimised for a CO2 neutral production process as digital fabrication, digitally enabled and optimised by the use of computational models. We will modell and generate algorithmically digital twins of the wall elements to will include information about material choices implications and consequences, such as heritage, sourcing to end of life cycle (cradle to cradle) and Life Cycle Assessment analysis, through which we aim for a holistic approach to building design, construction, operation and decommissioning.

Keywords: wall,loam,natural reinforcement,digital twin,algorithmic,natural composite,clay,natural fibers,biomimicry,biomimetics,prefabricated,modules,topology,computational design,textile
Optimality and Resetting: Investigation On Nonequilibrium (ORION)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

ORION project (Optimality & Resetting: Investigation On Nonequilibrium) poses three different problems, relevant at both the fundamental and applied level. Apart from their independent relevance, the solution of all three problems will serve to a greater purpose: providing a solid basis for the innovative use of optimal control theory to push the boundaries of knowledge within the general field of Nonequilibrium Statistical Mechanics. This action will involve the integration of the researcher in the very active group of Interdisciplinary and Nonequilibrium Physics (FINE) at University of Seville, with a strong background on the theory of mesoscopic systems—e.g. colloidal particles, for which fluctuations are important and the dynamics is thus stochastic. More specifically, the research objectives of ORION splits into: (i) the generalization of optimal control theory to connecting nonequilibrium steady states; (ii) the optimization of stochastic heat engines; and (iii) the minimization of first passage time in resetting systems with stochastic return. The achievement of these objectives will provide not only specific answers to pertinent questions for the above hot topics in the field, but also shed light on the future of investigation on nonequilibrium systems. Remarkably, the impact of our research transcends the purely theoretical interest, focusing on problems with future technological potential like the optimization of nanodevices—maximizing their power and/or efficiency.

Keywords: nonequilibrium statististical mechanics stochastic processes optimal control shortcuts to adiabaticity stochastic thermodynamics fokker planck eq stochastic heat engines stochastic resetting
Upgrade of the Centre of Excellence LignoSilva (LignoSilva)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Slovakia,Germany
Call: Teaming for Excellence (HORIZON-WIDERA-2022-ACCESS-01-two-stage, 2022)
Start date: 2024-01-01
End date: 2029-12-31
Duration (months): 72.0
Total project cost (EUR): 14710000.0
EU funding (EUR): 14710000.0
Participants: 3
Project status: SIGNED

The LIGNOSILVA Centre of Excellence for Forest-based industry stands for a systematic and structural change in the research landscape of the forest-based sector (FBS). The EU has made a strategic turn towards a circular bioeconomy, striving for a low-carbon society based on renewable sources, including wood biomass. It requires to transfer of knowledge and brings new innovation into FBS practice. FBS research landscape in Slovakia - as well as in countries with similar political histories - is highly fragmented and loses much of its potential due to insufficiently organised structures and strategies. Moreover, it is not linked to collaboration with Western/Northern EU countries. In the long run, this affects the entire value chain. The overall objective of the CoE is to contribute to overcoming these shortcomings by upgrading the existing LignoSilva Center of Excellence (CoE). The essence of upgrade lies in institutional reform that introduces European science management standards, increases excellence, expands research capacities, digital transformation based on the implementation of Forestry 4.0 and Pulp & Paper 4.0 into CoE research-innovation activities, support for open science and more efficient knowledge transfer to FBS. The main goal is to bring excellent research and applicable innovation into FBS in three research areas: - Intelligent technologies and systems supporting wood production and industrial wood processing. - Pulp and paper technologies for biodegradable packaging and special papers development with multifunctional properties - Recycling technologies and use of cellulose sludge and wood ash CoE LignoSilva's objective will be reached by concentrating the research and infrastructure capacities of the National Forestry Centre and the Pulp and Paper Research Institute in Bratislava. They will build up and foster cooperation with the advanced partners Fraunhofer Wilhelm-Klauditz-Institute (Germany).

Keywords: forestry 4 0,3d scanning,wood biomass,wood flow,pulp paper technologies,biodegradable packaging,smart packaging,special papers,pulp and paper 4 0,recycling,cellulose sludges,wood ash