Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Predicting mixed forests responses to climate change and drought stress with a plant hydraulics model (FORECAST)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-03-08
End date: 2023-03-07
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

The frequency and intensity of droughts are expected to increase in many regions of the world due to global climate change. Droughts can lead to widespread tree mortality, leading to a loss of carbon stored in forests that will feedback to exacerbate climate change. Thus, modelling forest responses to drought is critical for predicting climate change socio-economic and ecological impacts and informing conservation strategies. However, current models are not capable of adequately representing forest responses to drought, especially for mixed forests due to their diversity in species and functional traits. The proposed research intends to solve this problem by developing a model for mixed forests based on known biophysical constraints, plant functional traits and optimization theory. The model’s performance will be evaluated with (1) detailed measurements at Hayedo de Montejo (HM), a mixed Mediterranean forest with diverse functional traits, (2) data from a network of eddy-covariance towers that measure ecosystem fluxes, and (3) mortality data from two national forest inventories that span a wide range of forest types. Next, the model will be used for forecasting the vulnerability of HM to different climate change scenarios for guiding the conservation of this World Heritage Site. I will develop this project at Universidad Politécnica de Madrid, one of Europe’s leading academic institutions. A secondment at Centro de Investigación Ecológica y Aplicaciones Forestales (Barcelona) will allow me to learn new modelling approaches, gain access to global plant databases, and establish new collaborations. A secondment at Dirección General de Medio Ambiente y Sostenibilidad de la Comunidad de Madrid, a non-academic institution in charge of HM’s management, will ensure intersectoral transfer of knowledge among scientists, educators, managers and policy makers. This MSCA will facilitate my return to Europe and enhance my chances of obtaining a permanent position in Europe.

Keywords: climate change,competition,conservation,drought stress,ecophysiology,forest,management,modelling,plant functional traits,plant hydraulics,protected areas,water resources
Stimulating eco-sustainable home renovation to maximize social, environmental and economic impact on the Balearic Islands (REGENERATE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Reducing energy consumption and carbon foorpint by smart and sustainable use
Action type: Coordination and support actions
Countries involved: Spain,Spain,Spain,Spain
Call: Aggregation - Project Development Assistance (H2020-LC-SC3-EE-2020-2, 2020)
Start date: 2021-06-01
End date: 2025-05-31
Duration (months): 48.0
Total project cost (EUR): 1867181.35
EU funding (EUR): 1867181.35
Participants: 4
Project status: SIGNED

REGENERATE galvanizes clean energy transition on the three Balearic Islands: Palma, Ibiza and Menorca by triggering an investment of €44M in eco-sustainable renovation of 3,000+ homes in 4 years. The Islands have an urgent need to transform their tourism-dependent economy into a resilient and green one, as they are especially vulnerable to climate change and are highly dependent on fossil fuels. The REGENERATE’s renovation formula combines a market-driven, people-centric support with affordable financing, via in local One-Stop-Shop renovation offices on each island. REGENERATE’s pipeline approach is grounded in the realities of the islands building stock, defined energy efficiency & renewable energy upgrades, residents’ ability and willingness to pay. Thus, a realistic assessment of the pipeline supports the design of a self-sustainable business model for the OSS offices and enables the financing instrument to raise private capital to invest in individual home renovation projects. Stimulating bottom-up demand is at the core of this approach; REGENERATE will build upon the existing citizen engagement strategies on the islands and enhance their reach and scope. The impact goes well beyond energy savings, by boosting health, wellbeing and comfort of families, resulting in the reduction of more than 25,727 tCO2-eq/year and creating more than 4,000 jobs, 5 years after the project is completed.

Keywords: one stop shop,project developments,home renovation,energy efficiency,renewable energy,renovation loans,public private partnership,financing innovation,financing instruments
SCIENCE MEETS CITY (SCIENCEHOTEL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Netherlands
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-06-01
End date: 2021-05-31
Duration (months): 12.0
Total project cost (EUR): 150562.5
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Science Hotel is a festival where the general public in Rotterdam and its region meets with scientific researchers and is introduced in their research and its relevance for daily life. The theme of Science Hotel is ‘Science Meets City’ featuring the relevance of research for many aspects our lives in an urbanized world, such as sustainability, health, digitalization, AI, security and privacy, transport and mobility, trade and employment. The festival facilitates personal and interactive encounters between the audience and researchers in the form of interactive lectures, games, demo’s, tours and simulations. It invites the audience to step into the daily life of researchers and discuss research topics and their perception by societal stakeholders with the researchers, emphasizing that everyone is co-creating science one way or another. Dialogue is stimulated, enriched and sometimes distorted, by artists’ interventions arranged by Science Gallery Rotterdam. Pre-events mediated by the Science Street promotion team take place all over town during the month of September on places where members of the potential audience are: cultural festivals, social cultural centers in the neighborhoods of Rotterdam and shopping areas. Special pre-events will be offered for school pupils in primary and secondary education. You’re invited. Check in to Science Hotel!

Keywords: open science,science festival,co creation public engagement in science
ULTRAfast growth of ultrahigh performance SUPERconducting TAPEs (ULTRASUPERTAPE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2015-12-01
End date: 2022-05-31
Duration (months): 78.0
Total project cost (EUR): 2496652.0
EU funding (EUR): 2496652.0
Participants: 1
Project status: CLOSED

ULTRASUPERTAPE aims to demonstrate an unprecedented approach for fabrication of low cost / high throughput / high performance High Temperature Superconducting (HTS) tapes, or Coated Conductors, to push the emerging HTS industry to market. The breakthrough idea is the use of Transient Liquid Assisted Growth from low cost Chemical Solution Deposition of Y, Ba, Cu metallorganic precursors to reach ultrafast growth rates. The key concept relies on the discovery of a tool to control the ignition effect of the transient liquid formation through the decomposition of barium carbonate even for thick films. The capability to modulate the transient liquid state with composition variations and low cost capital investment equipment enriches its potentiality. Innovative Additive Manufacturing and Digital Printing methodologies are identified to devise an integrated system able to address the full manufacturing process from solution deposition by ink jet printing to ultrafast epitaxial crystallization of the superconducting phase. A combinatorial chemistry strategy ensures fast screening operation. Furthermore, ULTRASUPERTAPE will boost Coated Conductor performances up to outstanding limits at high and ultrahigh fields, by smartly designing and engineering the local strain and electronic state properties of nanocomposite superconducting films. The digital-printing additive-manufacturing approach developed will be cleverly adapted to create unique superconducting nanocomposites from nanoparticle colloids with unlimited concentrations. This new instrument is foreseen to be transferable to many other functional applications of advanced nanocoatings, where long length or large area production of functional epitaxial films or multilayer structures are required. Consequently, wise ideas and technology emerged from this proposal are foreseen to penetrate the new energy paradigm beyond the clean, efficient and smart limits that Superconductivity offers.

Keywords: high temperature superconductors,coated conductors,epitaxial nanocomposites,transient liquid growth,additive manufacturing,ink jet printing,chemical solutions deposition,electrical energy
In situ stress analysis of lithium-ion battery cell (LIB STRESS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-07-30
End date: 2020-07-29
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Lithium-ion batteries (LIB) are found in many applications such as consumer electronics, electric vehicles and airplanes. However, despite of the high safety standards being imposed, there have been many reported accidents as well as recalls by some manufacturers. Most accidents can be sourced to runaway reactions, which could happen if the LIBs are overheated or overcharged. Thermal runaway can cause rapid temperature rise in the LIB, resulting in excessive thermal stress in the electrodes and the separator, a permeable membrane placed between the anode and cathode. Such mechanical degradation can cause the fading of battery capacity, and in extreme cases result in cell rupture, releasing of flammable gases, fire and explosions. The proposed research is aimed at analysing the thermal behaviour and structure response of LIB cells during charge and discharge cycles as well as abnormal conditions such as overcharging and under impact by a projectile. The cutting edge phase field model (PFM) will be combined with multi-physics finite element code COMSOL to analyse the deformation induced stresses induced by insertion of lithium in the electrodes under constraints and high temperatures as well as the resulting crack or microfracture in the electrode materials. The PFM is different from discrete fracture and continuum damage models and ideal for dealing with branch crack and multiple crack problems. The specific objectives of the research include: - Investigate LIB cell temperature changes under abnormal conditions such as overcharging and under impact by a projectile. - Implement the PFM in COMSOL to handle the electrochemical reaction on surfaces, phase interfaces and crack surfaces in lithium ion battery electrode particles. - Validate the above with published results and new data to be generated by partner organisation. - Investigate the combined effects of electrochemical, mechanical and thermal on LIB behaviour and performance. - Final analysis and report.

Keywords: lithium ion battery,thermal runaway,mechanical degradation,cell rupture,thermal behaviour,structure response,smoothed finite element and phase field model
The Effect of DNA Topology on Eukaryotic Replication (TOPOREF)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

The replication of DNA is one of the fundamental processes that drives all life. Errors in replication are responsible for a host of human diseases as well as for all adaptation and evolution, and hence the mechanisms, regulation, and fidelity of this process are of great interest to both fundamental biology and medical research. A complete, active replisome was recently reconstituted in yeast, allowing unprecedented probing and control of eukaryotic DNA replication in in vitro experiments. In this fellowship, I will take the exciting new opportunity offered by this breakthrough to study how torque and twist in the DNA double helix affect replisome activity. I will measure how DNA supercoiling affects replisome assembly and how the progressive buildup of torque impacts its progression along DNA. At the torque that fully stalls the replisome, I will determine its still-unknown composition. Finally, I will examine how such torque buildup impacts the disruption of nucleosomes present on the DNA to assess whether this effect can play a significant role in vivo. To achieve these scientific insights, I will both make use of the biological expertise and single-molecule instrumentation that are available in the host laboratory (e.g. TIRF microscopy, magnetic tweezers), and use my expertise to develop and exploit an integrated instrument that facilitates evaluation of replisome composition on different DNA substrates. These experiments will shed light on the functioning of the eukaryotic replisome, particularly its dynamic response to force and torque. The use of single-molecule techniques to study the full replisome is unprecedented, and the development of an integrated tweezers/TIRF instrument will be unparalleled in the depth of insight it can offer. In doing so, I will answer key questions about the structure and dynamics of the replisome, examine the role of DNA topology in replication, and open up a wealth of avenues for future investigation.

Keywords: dna replication,eukaryotic replication,yeast replication,nucleosomes,fluorescence microscopy,force and torque spectroscopy,magnetic tweezers,single molecule biophysics
Single-molecule visualization of transcription dynamics to understand regulatory mechanisms of transcriptional bursting and its effects on cellular fitness (BURSTREG)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Netherlands
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2022-12-31
Duration (months): 60.0
Total project cost (EUR): 1950775.0
EU funding (EUR): 1950775.0
Participants: 1
Project status: SIGNED

Transcription in single cells is a stochastic process that arises from the random collision of molecules, resulting in heterogeneity in gene expression in cell populations. This heterogeneity in gene expression influences cell fate decisions and disease progression. Interestingly, gene expression variability is not the same for every gene: noise can vary by several orders of magnitude across transcriptomes. The reason for this transcript-specific behavior is that genes are not transcribed in a continuous fashion, but can show transcriptional bursting, with periods of gene activity followed by periods of inactivity. The noisiness of a gene can be tuned by changing the duration and the rate of switching between periods of activity and inactivity. Even though transcriptional bursting is conserved from bacteria to yeast to human cells, the origin and regulators of bursting remain largely unknown. Here, I will use cutting-edge single-molecule RNA imaging techniques to directly observe and measure transcriptional bursting in living yeast cells. First, bursting properties will be quantified at different endogenous and mutated genes to evaluate the contribution of cis-regulatory promoter elements on bursting. Second, the role of trans-regulatory complexes will be characterized by dynamic depletion or gene-specific targeting of transcription regulatory proteins and observing changes in RNA synthesis in real-time. Third, I will develop a new technology to visualize the binding dynamics of single transcription factor molecules at the transcription site, so that the stability of upstream regulatory factors and the RNA output can directly be compared in the same cell. Finally, I will examine the phenotypic effect of different bursting patterns on organismal fitness. Overall, these approaches will reveal how bursting is regulated at the molecular level and how different bursting patterns affect the heterogeneity and fitness of the organism.
NextPerception - Next generation smart perception sensors and distributed intelligence for proactive human monitoring in health, wellbeing, and automotive systems (NextPerception)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Research and Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Germany,Germany,Spain,Italy,Italy,Italy,Italy,Germany,Germany,Spain,Spain,Germany,Spain,Spain,Spain,Italy,Italy,Italy,Belgium,Belgium,Belgium,Belgium,Belgium,Belgium,Finland,Finland,Finland,Finland,Czechia,Czechia,Netherlands,Netherlands,Netherlands,Netherlands
Call: ECSEL-2019-2-RIA (H2020-ECSEL-2019-2-RIA, 2019)
Start date: 2020-05-01
End date: 2023-07-31
Duration (months): 39.0
Total project cost (EUR): 28707669.5
EU funding (EUR): 8728813.49
Participants: 44
Project status: SIGNED

We put our lives increasingly in the hands of smart complex systems making decisions that directly affect our health and wellbeing. This is very evident in healthcare - where systems watch over your health - as well as in traffic - where autonomous driving solutions are gradually taking over control of the car. The accuracy and timeliness of the decisions depend on the systems’ ability to build a good understanding of both you and your environment, which relies on observations and the ability to reason on them. This project will bring perception sensing technologies like Radar, LiDAR and Time of Flight cameras to the next level, enhancing their features to allow for more accurate detection of human behaviour and physiological parameters. Besides more accurate automotive solutions ensuring driver vigilance and pedestrian and cyclist safety, this innovation will open up new opportunities in health and wellbeing to monitor elderly people at home or unobtrusively assess health state. To facilitate building the complex smart sensing systems envisioned and ensure their secure and reliable operation, the new Distributed Intelligence paradigm will be embraced, enhanced and supported by tools. It leverages the advantages of Edge and Cloud computing, building on the distributed computational resources increasingly available in sensors and edge components to distribute also the intelligence. The goal of this project is to develop next generation smart perception sensors and enhance the distributed intelligence paradigm to build versatile, secure, reliable, and proactive human monitoring solutions for the health, wellbeing, and automotive domains The project brings together major industrial players and research partners to address top challenges in health, wellbeing, and automotive domains through three use cases: integral vitality monitoring for elderly and exercise, driver monitoring, and providing safety and comfort for vulnerable road users at intersections.

Keywords: perception sensors,radar,lidar,time of flight,distributed intelligence,edge computing,explainable ai,human monitoring
Peptide-Drug Conjugates for Targeted Delivery in Tumor Therapy (MAGICBULLET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Germany,Italy,Italy,Germany,Italy,Italy,Germany,Finland,Hungary,Hungary
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3746420.28
EU funding (EUR): 3746420.28
Participants: 14
Project status: CLOSED

Many tumor cells are characterized by the overexpression of certain antigens. Molecules that specifically recognize these structures are suitable as homing devices in tumor therapy. Conjugates of anticancer drugs with such a delivery vector targeting tumors would be a “magic bullet” according to the Nobel laureate Paul Ehrlich. Three antibody-drug conjugates (ADC) have already been approved for anticancer therapy. However, ADC have e.g. limitations with respect to tumor penetration, high manufacturing costs, and require challenging conjugation chemistry. Peptide-drug conjugates can have a high drug loading, easily penetrate tissue, and can be easily prepared in a homogenous form with straightforward and well-defined conjugation chemistry. The ETN MAGICBULLET will focus on chemistry-driven approaches toward conjugates between peptides (delivery vectors) that recognize tumors and anticancer drugs (payloads or warheads) in order to selectively fight cancer, a topic with a high demand of research activities. The ETN will develop and validate an array of new peptide-drug conjugates combining either known tumor-specific peptides or newly discovered tumor-homing peptides with potent cytotoxic drugs. The tumor-selective peptides are designed for cellular uptake mediated either by endocytosis or by cell-penetrating peptides. The consortium of the ETN MAGICBULLET covers tumor biology, biochemistry, pharmacology, synthetic chemistry, medicinal chemistry, spectroscopy, conformational analysis, and computational chemistry. The training program focuses on multidisciplinary research to explore and validate molecular targets for innovative treatment or investigations on the molecular mechanisms in organ-specific metastatic growth processes. It aims at scientific multilingualism and relies e.g. on concerted learning, a combination of introductory training, hands-on learning “on the bench”, teaching by peers, and training in additional skills.

Keywords: peptide drug conjugates tumor targeting homing device cytotoxic drug natural products drug delivery