Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Framework of Innovation for Engineering of New Durable Solar Surfaces (FRIENDS2)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Austria,Spain,Spain,Germany,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 346500.0
EU funding (EUR): 346500.0
Participants: 6
Project status: CLOSED

Increasing the share of renewables in the European energy mix has a key function for the security of energy supply and the reduction of greenhouse gas emissions from fossil fuels. This proposal is entitled “Framework of Innovation for Engineering of New Durable Solar Surfaces”, (acronym FRIENDS2) and aims at achieving a European network for the transfer of knowledge to establish a shared culture of research and innovation which allows turning creative ideas in the field of surface engineering into innovative solutions for concentrating solar power (CSP) applications. FRIENDS2 will be led by one large European industry (Abengoa) who is a world leader in the development of CSP plants. The other FRIENDS2 participants are two well-recognized academic organizations (the University of Cranfield and the Helmholtz-Zentrum Dresden - Rossendorf e.V.), and one SME (Metal Estalki). The purpose of FRIENDS2 is to strengthen the inter-sectoral capabilities in research and development of coating designs in order to improve the performance of CSP key components (reflectors, receivers and containers for heat storage) for high temperature applications. The methodology of this joint research proposal contains aspects of very high novelty. It includes computer modelling, multi-technique coating deposition, use of advanced characterization techniques, and the possibility of scaling-up new coating developments. Special attention is paid to the intersectoral transfer of knowledge and to the establishment of a long-lasting international network with global impact. It is worth noting that a substantial fraction of secondments (51%) will be carried out from the industrial to the academic sector. With the proposed approach, there will be an effective transfer of knowledge among the partners which will pave the road from fundamental research to applied innovation of surface engineering solutions for further CSP development.

Keywords: thermosolar energy,reflective coatings,heat storage,absorber coatings,surface engineering,csp plants,corrosion resistance,on field evaluation,industrial scale up,in situ characterization
Relative representation theory and distributions on reductive groups over local fields (RelRepDist)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Israel
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-03-01
End date: 2020-12-31
Duration (months): 70.0
Total project cost (EUR): 1196215.0
EU funding (EUR): 1196215.0
Participants: 1
Project status: CLOSED

One can view the representation theory of a topological group as non-commutative harmonic analysis on the group. For compact groups this view is justified by the Peter-Weyl theorem. The relative representation theory of a group is harmonic analyses on spaces with transitive group action. I work in relative representation theory of reductive (algebraic) groups over local fields, e.g. the general linear group over the field of real numbers or the field of p-adic numbers. This theory has applications to the theory of automorphic forms, in particular to the relative trace formula. There are many similarities between the real and p-adic cases, and some results can be formulated uniformly for all local fields, but their proofs are usually specific to each type of local fields. An important tool in this theory, that is applicable for all local fields, is the analysis of equivariant distributions on the group. However, this analysis is quite different for the two kinds of fields. In the first part of this proposal I describe my ongoing work on some tools that will help to approach invariant distributions uniformly for all fields. I also propose to advance, using those tools, towards the proofs of some long-standing conjectures on density of orbital integrals, comparison of Lie algebra homologies, and classification of (non-compact) Gelfand pairs. The second part of this proposal concerns generalized Whittaker models, or equivalently harmonic analyses on the quotient of a reductive group by a unipotent subgroup. In 1987 Moeglen and Waldspurger comprehensively described the role of a representation in this harmonic analyses in terms of a certain collection of nilpotent orbits attached to this representation. This result, as well as previous results on Whittaker models have many applications in representation theory and in the theory of automorphic forms. I propose to obtain an archimedean analog of this result.

Keywords: representation theory,theory of distributions,microlocal analysis,harmonic analysis,relative trace formula
Development of a mobile device for the quick on-site measurement of soil nutrients (MobiLab)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Austria
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Today the application of fertilisers to agricultural crops is mainly based on calculations, estimations and recommendations and not on analyses of the actual demand of soil and plants. The resulting over-fertilisation has substantial disadvantages: pollutions of the groundwater, the eutrophication of surface water bodies, emissions of greenhouse gas from the soil, the depletion of finite natural resources, reduced yields and unnecessary expenses for fertilisers. It is estimated that up to 35 % of the applied fertiliser could be saved if a method for the quick and simple determination of the fertiliser demand existed. Pessl GmbH, an Austrian SME specialised in the development of innovative products in the field of precision farming, has developed a lab-on-a-chip sensor for the quick on-site determination of the concentrations of the most important plant nutrients (ammonia, nitrate, phosphate and potassium) in the soil. This sensor will enable farmers to determine the fertiliser requirements of their fields within just a few minutes and without the need for any special knowledge. Based on the results of the EU project OPTIFERT Pessl has developed a first prototype of the sensor which has demonstrated the proper functioning and the great potentials of the technology. However, improvements and adaptations are required to achieve the market breakthrough. In this proposed project a feasibility study will reveal the technical feasibility of the envisaged improvements and the optimal way of implementation, while a business plan will show the optimal way of commercialisation. Pessl’s new nutrient sensor will help European farmers to save up to 35 % of their applied fertiliser, leading to total annual savings of up to 6 billion € or 500 € per average farmer. At the same time Pessl GmbH will be able to significantly grow in terms of turnover, profit and employees and to further expand its leading position on the European market for precision farming products.

Keywords: fertilisation,precision farming,lab on a chip
Aging Lungs in European Cohorts (ALEC)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Iceland,Germany,Italy,Australia,Spain,Norway,Switzerland,France,United Kingdom,United Kingdom,United Kingdom
Call: Understanding health, ageing and disease: determinants, risk factors and pathways (H2020-PHC-2014-two-stage, 2014)
Start date: 2015-05-01
End date: 2019-04-30
Duration (months): 48.0
Total project cost (EUR): 7271433.75
EU funding (EUR): 5534094.25
Participants: 13
Project status: CLOSED

This programme of work will advance the understanding of the combined effects of factors that cause poor lung function, respiratory disability and the development of COPD . This will be achieved by examination of determinants of lung growth and lung function decline within existing cohorts that cover the whole life course, and which have followed, in detail, the respiratory health status of over 25000 European children and adults from the early 1990’s to the present day. Following a comprehensive programme of risk factor identification we will generate a predictive risk score. The programme includes 1) identification of behavioural, environmental, occupational, nutritional, other modifiable lifestyle, genetic determinant of poor lung growth, excess lung function decline and occurrence of low lung function, respiratory disability and COPD within existing child and adult cohorts 2) generation of new data to fill gaps in knowledge on pre-conception and transgenerational determinants and risk factors 3) validation of the role of risk factors by integration of data from relevant disciplines, integration of data from the cohort-related population-based biobanks and exploitation of appropriate statistical techniques 4) generation of information on change in DNA methylation patterns to identify epigenetic changes associated with both disease development and exposure to specific risk factors 5) generation of a predictive risk score for individual risk stratification that takes account of the combined effects of factors that cause poor lung growth, lung function decline, respiratory disability, and COPD and 6) implementation of an online interactive tool for personalised risk prediction based which will be disseminated freely and widely to the population, patients and health care providers. The work will provide an evidence base for risk identification at individual and population level that can underpin future preventive and therapeutic strategies and policies.

Keywords: lung growth,lung function decline,copd,cohorts,risk factors
Complement-mediated phagocytosis in neutrophils (CR-PHAGOCYTOSIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-01
End date: 2017-03-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Complement-mediated phagocytosis plays a crucial role in bacterial killing. Activation of complement yields a variety of opsonin molecules that can rapidly coat bacterial surfaces, which interact with complement receptors on neutrophils to facilitate phagocytosis. However the molecular details and functional outcomes of these interactions are not well understood. In the proposed work, we aim to elucidate the molecular details of complement opsonin-receptor interactions. We have developed a novel model for examining molecular complement interactions, by site-specifically attaching complement opsonins to bacteria-sized beads in their correct orientation. We will, for the first time, be able to adequately characterize complement opsonin-receptor interactions at a molecular level. This methodology will also be extended to two model gram-positive bacteria, Staphylococcus aureus (S. aureus) and Group B Streptococcus (GBS), in which complement opsonins will be site-specifically attached to their cell walls. Using wild-type and complement receptor (CR) knockdown neutrophils, we aim to determine the roles of opsonin-receptor pairs in neutrophil activation and bacterial killing. Finally, we will use our model systems to examine the synergy between antibodies and complement in neutrophil phagocytosis. The proposed work will provide a comprehensive picture of the role of complement in neutrophil phagocytosis. As the role of complement in human disease is becoming increasingly apparent, the need for new therapeutics is imminent. The work proposed herein paves the way for several therapeutic applications, including targeted complement-dependent cytotoxicity (CDC) immunotherapeutics in cancer and complement inhibitors for a wide array of age-related, autoimmune, and rare/neglected disorders.

Keywords: complement,phagocytosis,neutrophil,gram positive bacteria,opsonization
Discovery and validation of ‘epidrivers’ of cancer evolution and resistance to therapy (METCLL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2021-08-31
Duration (months): 36.0
Total project cost (EUR): 264668.4
EU funding (EUR): 264668.4
Participants: 2
Project status: CLOSED

Intra-tumoral heterogeneity allows all form of cancers to undergo an evolutionary process in response to selective pressures, such as therapy, which results in a more aggressive disease. As chronic lymphocytic leukemia (CLL) are particularly amenable to evolutionary investigations, it has been shown that CLL’s capacity to escape therapy is linked in to genetic evolution, which is fueled by intra-tumoral heterogeneity. Aberrant DNA methylation can also dysregulates genes involved in CLL pathogenesis. Like genetic alterations, DNA methylation modifications are heritable and subject to natural selection. Landau et al have studied sub-population DNA methylation heterogeneity in CLL and uncovered a large amount of stochastic variation. The acquisition of stochastic DNA methylation alterations enhances epigenetic plasticity and creates a non–genetically encoded source of heterogeneity, fuelling tumour cells in their search for superior evolutionary trajectories. These new data modify the way we understand cancer epigenetics, and offer a new field of investigation: identify “epidrivers”, i.e. somatic epigenetic alterations leading to cancer-heterogeneity and which are positively selected through cancer evolution. Thus, I will pursue in this project four independent yet complementary aims. During my outgoing period I will robustly identify epidrivers from bulk next-generation sequencing (NGS) (Aim 1) and from single-cell NGS (Aim 2) of a large CLL cohort. Candidate epidrivers uncovered from the first two aims, will be further validated in a large-scale epigenome editing screen (Aim 3). Then building upon technological development from Aim 2 and 3, during my returning period at Curie Institute, I will extend this important paradigm to solid tumor by exploring breast cancer evolution (Aim 4). This integrative analysis of epigenetic heterogeneity will enable the reconstruction of tumor epigenetic population complexity and how it shapes disease relapse and evolution.

Keywords: dna methylation,clonal evolution,breast cancer
Eruption Source Parameters for Explosive Eruptions in Iceland Over the Last 3 ka (ESPSI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Iceland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-06-15
End date: 2019-06-14
Duration (months): 24.0
Total project cost (EUR): 179325.6
EU funding (EUR): 179325.6
Participants: 1
Project status: CLOSED

Eruption source parameters (ESPs)—such as erupted volume/mass, plume height, magma discharge, tephra dispersal, and total grain size distribution (TDGS)—are key information for characterizing explosive eruptions and essential input parameters in tephra dispersal models used for real-time forecasting by the Volcanic Ash Advisory Centers (VAACs) and for long-term hazard assessments. Iceland is one of the volcanically most active regions of the world, with over 20 events per century. About ~700 events are preserved in the post-glacial soil and lake sediments in Iceland. ESPs, however, have yet to be determined for most of the eruptions. ESPs are traditionally derived using empirical approaches, requiring detailed field measurements of the deposits. The objective of this action is to estimate, to the first order, the ESPs for explosive eruptions in Iceland using inversion modelling. The advantage of this approach is that it bypasses the compilation of detailed isopach maps through the use of optimization algorithms. It requires only a limited number of thickness measurements and grain size analyses. Consequently, ESPs can be established for a larger number of eruptions in a shorter time, than when using traditional empirical methods. This will result in a statistically robust data set on ESPs used for determining the magnitude and intensities of explosive eruptions in Iceland as well as for assessing risk and mitigating hazards associated with such events.

Keywords: explosive eruptions,eruption source parameters,inversion modelling,tephrochronology
A next generation nanomedia that can be tailored to capture and recycle specific micropollutants in contaminated industrial waste discharge (CGM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Accelerating the uptake of nanotechnologies advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-06-01
End date: 2017-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Customem Ltd is a company founded in 2014 with the long term vision to harness nature’s capacity to make biomaterials to promote human health in alignment with sustainable development goals.A next generation nanomedia that can be tailored to capture and recycle specific micropollutants in contaminated industrial waste dischargeLack of access to clean water is predicted to affect 47% of the world’s population by 2030. Contamination of water supplies by micropollutants such as metal ions, pesticides and pharmaceuticals is a major contributor to this water stress. These pollutants are released by industrial processes in the textile and manufacturing industries. Existing water treatment removes 99.96% of contaminants, but does not remove the 0.04% of micropollutants. Although the remaining contaminants seem small, they are a major problem as they are exceptionally difficult to capture but also highly toxic to humans and animals. CustoMem have developed a customisable selective nanocellulose media called CustoMem Granular Media (CGM) that is bioengineered to capture and remove all micropollutants including the 0.04% that cannot currently be removed.Customers benefit from a simple, low cost, low energy solution that is low maintenance. It allows removal of all micropollutants resulting in clean water supplies. The company is headquartered in the Imperial College Incubator UK and employ 5 full time employees and multiple subcontractors. The company is currently in talks with companies in the EU who have shown an active interest in the project.

Keywords: nano materials,micropollutants,clean water,filtration,heavy metals,contaminants
GaN mm-wave Radar Components Embedded (GRACE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Sweden,France,France
Call: Development of 94 GHz (W-band) Radar Components (H2020-CS2-CFP07-2017-02, 2017)
Start date: 2018-11-01
End date: 2021-08-31
Duration (months): 34.0
Total project cost (EUR): 1742815.0
EU funding (EUR): 1742815.0
Participants: 4
Project status: CLOSED

The GRACE project aims at development of surface mount technology (SMT) components for mm-wave (mmW) frequencies, with particular focus on radar systems in the W-band. Low-cost high-performance radars are critical for future Enhanced Flight Vison System (EFVS) combining IR sensors and a mmW radar. Key radar components are Power Amplifier (PAs) and Signal Sources (SSs), two functionalities that require high power. The most promising technology to deliver the required power levels in an area-effective package with potential to be cost-effective in volume production is a short-gate length GaN HEMT monolithic microwave integrated circuit (MMIC) technology. The GRACE project aims at utilizing the D01GH and the D006GHG processes from OMMIC, which are two only commercially open European MMIC processes with capability of delivering sufficient gain in the W frequency band. The GRACE project also aims at packaging the designed MMICs using a fan-out wafer level (FOWL) packaging approach offered by Fraunhofer IZM. FOWL packaging (FOWLP) is one of the latest packaging trends in microelectronics with advantages such as significant package miniaturization, substrate-less package, lower thermal resistance, and higher performance with lower loss and low parasitic coupling The specific objectives of the GRACE project are: *Design of a 93-100 GHz Power Amplifier (PA) MMIC with an output power in the range of 500mW to 1W *Design of a signal-source MMIC covering 93-100 GHz with state-of-the art far-carrier phase noise performance *Development of a FOWL packaging flow for the PA MMIC *Development of a FOWL packaging flow for the signal source MMIC

Keywords: mm wave radar components,surface mount technology smt,gan hemt,mmic,signal source,phase noise,power amplifier pa,packaging,fan out wafer level fowl package