Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Variance Aware Determinate assembly Integrated System (VADIS)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: United Kingdom,United Kingdom,United Kingdom
Call: Development and delivery of a flexible assembly system based on reverse engineering, tolerance analysis and Determinant Assembly Approach of wing box (H2020-CS2-CFP03-2016-01, 2016)
Start date: 2017-10-01
End date: 2022-09-30
Duration (months): 60.0
Total project cost (EUR): 1914187.5
EU funding (EUR): 1699987.5
Participants: 3
Project status: CLOSED

The VADIS project aims to develop innovative and ground breaking assembly methods and solutions for cost effective wing manufacture for the future regional aircraft based on reverse engineering, intelligent process adaption, and variability aware processes and tooling. The project will develop and implement new digital design and simulation techniques, combined with future highly efficient, informatics rich and quality-driven cost-effective manufacturing solutions which will be rigorously tested and validated to deliver an integrated future wing box assembly cell. VADIS will produce an integrated wing box assembly cell for future regional aircraft, taking advantage of the latest advances in metrology, digital manufacturing and process adaption to achieve part-to-part assembly. A high tolerance deterministic assembly approach will be applied to reduce parasitic drag caused by traditional panel gaps. Reconfigurable assembly tooling will be used to reduce tooling costs allowing the most efficient response and flexibility in design changes. Low energy low cost mould tooling and out of autoclave processing will be exploited to achieve significant cost reduction. Synergies with current developments of fixed wing airframe ITD will be explored to promote best practice based on the existing strong industrial and research expertise in the consortium. The VADIS project will deliver the following target outcomes: Variability analysis and characterization for process and fixture tolerances; Assembly process capability assessment and investigation of feasible tolerance range widening; Technology benchmarking for optimised design of a self-adaptive fixture, metrology system for reverse engineering, cell layout and software for digital twin creation; Achieve ±0.006 mm accurate reverse engineering solution; Adaptively updating digital twin of spar-rib-skin assembly model; Cell process adaption capability to achieve part-to-part assembly.

Keywords: determinate assembly,fixturing,drilling,metrology
A web-based Decision Support System to score forest understorey dynamics in response to management interventions in a changing world (UnderSCORE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Belgium
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-07-01
End date: 2020-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Currently, forest management models focus predominantly on tree dynamics following interventions, and tend to ignore the plant species found below the trees on the forest floor (the understorey). This is a crucial oversight, as the understorey is the major component of biodiversity, provides vital ecosystem services, and can influence the overall functioning of the forest. As such, there is a need for a user-friendly tool to help predict key understorey plant performance indicators (e.g. biodiversity, share of species of conservation concern) across environmental contexts (e.g. macroclimate space, land-use history) and overstorey tree management (e.g. timber species choice, forest management systems, rotation times). Based on the outcomes and insights from the ERC Consolidator Grant PASTFORWARD we propose to solve the lack of a user-friendly tool for understanding vital understorey dynamics by first creating a prototype web-based Decision Support System (UnderSCORE). Creating this tool will transfer the research output of the ERC PASTFORWARD project into a form that is of direct use for policy makers and forest managers. Such a tool is not currently available but clear legal and societal imperatives (e.g. Natura 2000, European Biodiversity Strategy) require its development, and provide the context for its adoption by potential users. The first stage of this proof-of-concept project is to explore and confirm the understorey output data end users require, the input data they could typically provide, and the type of management interventions that they would typically contemplate. In the second stage, we will use this end user information, in conjunction with the distinctive scientific output of PASTFORWARD, to develop a prototype of the DSS. After the development of a first prototype, the DSS will be evaluated by a panel of end-users and then further optimized in order to guarantee maximal use and impact of UnderSCORE.

Keywords: understorey vegetation,global change,decision support system,forest management,forest policy
High quality real time broadcasting technology that provides reliable and resilient signal. (Os-X)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-01-01
End date: 2019-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Omnistream is an innovative and game changing Israeli start-up that has developed Os-X – an innovative and reliable communication platform, using cellular bonding technology, for transmission of high quality and real time video, audio and data. Os-X has been especially designed to help local enforcement organizations to communicate during events where communications networks may stop functioning such as, popular sport events, live concerts, terror attacks, and big demonstrations. Os-X uses cellular modem (SIM card) or plurality of modems, to create a bigger resilient and secure uplink bandwidth. The platform communicates with all discoverable 3G / 4G cells and select the best antenna to connect to, based on the measurement of uplink performances parameters. Omnistream wishes to leverage specific innovation topics in the security arena that can be funded under SME-Instrument in order to take the product to the market as quickly as possible.

Keywords: real time broadcasting,cellular modem,antenna,cell bonding
Integrating biology and behaviour for precision stratification of mental disorders (MENTALPRECISION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

In many areas of medicine, biomarkers have revolutionised diagnosis and personalised treatment allocation (‘precision medicine’). Psychiatry lags behind: disorders are still diagnosed by symptoms and no biomarkers have been found. However, addressing this is a formidable task because of a lack of analysis tools to understand the complex disruptions of mental disorders at multiple levels –from neurobiology to behaviour– and to tackle their extreme heterogeneity at every level. My vision is to provide a set of principled, next generation analysis tools to stratify mental disorders on the basis of biomarkers derived from population-scale neuroimaging and quantitative measures of behaviour from smartphone-based digital phenotyping. I will build generative models to chart variation in brain organisation across massive neuroimaging samples from more than 40,000 individuals based on ‘brain growth charting’ methodology I have pioneered. This will provide a universal platform to understand shared and distinct mechanisms of mental disorders at the level of the individual, simulate clinical brain states and test putative interventions using synthetic data. I will develop innovative machine learning tools to: (1) learn latent dynamics of digital phenotyping measures; (2) parse the dynamic interplay between brain systems and the behaviours they underpin; (3) integrate complementary information from distinct data modalities and (4) stratify mental disorders in a way that cuts across diagnostic classifications and accommodates different mechanisms converging on the same symptoms. These innovations will have far-reaching impact; here, I will showcase them by predicting trajectories of resilience and risk in major depression and bipolar disorder which are a leading cause of worldwide disease burden. This will bring precision medicine within reach for psychiatry allowing early, personalized intervention, preventative treatments and a better understanding of disorder entities.
Reassessing Late Ottoman Literatures within a Mediterranean Framework (OttMed)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Türkiye
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-05-31
Duration (months): 24.0
Total project cost (EUR): 145845.6
EU funding (EUR): 145845.6
Participants: 1
Project status: CLOSED

Arslan’s project proposes a new paradigm for studying late Ottoman literatures that were written in the nineteenth and early twentieth century and in different languages such as Arabic, Ottoman Turkish, and French by situating these literatures in a multilingual and multicultural Mediterranean framework instead of their respective national communities. His project will build upon three dimensions that constitute the objectives of his study. (i) The history dimension will map out literary and cultural exchanges within the nineteenth-century and early twentieth-century Mediterranean through archival research and digital humanities techniques. (ii) The criticism dimension will demonstrate that thematic preoccupations of Mediterranean literatures—including but not limited to diaspora, travel, imperialism, cultural hybridity, and fluidity of borders and identities—were also defining characteristics of late Ottoman literatures via a close reading of canonical late Ottoman works. (iii) The theory dimension will draw upon the latest debates in postcolonial studies, migration and diaspora studies, and world literature to examine how the Mediterranean can be used as a category of analysis in cultural and literary studies. Building upon these three objectives, Arslan’s project will put two fields—Mediterranean studies and Ottoman studies—in dialogue with each other to generate a disciplinary transformation of both, while undermining the ways in which late Ottoman literatures have been categorised and studied. Having just finished his Ph.D., Arslan hopes to have an advantageous start at his career by the end of this fellowship through completing a substantial portion of a sole-authored monograph, publishing peer-reviewed articles and policy briefs, organising conference panels and communication activities, and joining networks of scholars in North Africa, Europe, and the Middle East who work on Mediterranean and Ottoman studies.

Keywords: ottoman literatures,mediterranean studies,digital humanities,nineteenth century,modernity,middle eastern literatures,french literature,greek literature,arabic literature,turkish literature
Quotanda - a lending-as-a-service (LaaS) platform that enables schools and lenders to set up student financing programs to make education more affordable (Quotanda)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-08-01
End date: 2017-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Quotanda is a lending as a service (LaaS) platform providing a suite of student loan services. Its technology and staff supervise all aspects of partners’ online lending programs, including: program set-up, marketing, compliance to selection requirements, origination, automated credit decisions, loan disbursement, extended servicing (collecting interest and principal), and default management. As a B2B2C LaaS platform, two are the main groups Quotanda is addressing to: banks and schools through which students, which are the final users, are eventually pointed. Quotanda manages all aspects of loan programs for banks or extended payment plans for schools. It supports economic growth via wage premiums for educated (or re-skilled workers) and helps to reduce deficiencies of inequality and social exclusion. Quotanda is challenging the status-quo with a technology that broadens financial inclusion and access to education by helping schools to introduce flexible and affordable financing programs for students, as shown by the 2 successful loan programs running in Spain in collaboration with IESE Business School MBA and IronHack – Spain’s first code bootcamp. On the other side it helps banks to acquire millennial customers with high Lifetime Value efficiently while making students and families loan decision faster. Having proved online origination and servicing capabilities, Quotanda sees this feasibility study as an opportunity to help grow and test its turnkey platform on a larger level, by bringing superior efficiency at scale to various banks and schools. Its concept greatest ambition is to set a standard the education lending market with an increasing share that will arrive to count at least for 1.75% of the entire online education lending market in the forthcoming 4 years, by closing partnerships with 11 lenders and 40 among universities, schools and code bootcamps by the end of 2017.

Keywords: lending as a service,education,student financing,tertiary education
Learning in emotionally vulnerable people (LEARNVUL)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Italy,Belgium,Romania
Call: Twinning (H2020-WIDESPREAD-2020-5, 2020)
Start date: 2020-10-01
End date: 2023-09-30
Duration (months): 36.0
Total project cost (EUR): 900000.0
EU funding (EUR): 900000.0
Participants: 3
Project status: SIGNED

Neuroticism is a non-pathological personality trait established as a risk factor for emotional problems, but the cause of this relationship is unclear. The proposed project aims at making steps towards clarifying this effect from an evaluative learning perspective and at raising West University of Timisoara (UVT) as a leading contributor to this topic. UVT has a proved potential for excellency but needs to upgrade its research practices in order to further translate it into actual scientific excellency. In this regard, a collaborative network will be set with two internationally-leading research institutions: University of Milan Bicocca (UNIMIB) and Ghent University (UGENT). In order to reach the overarching aim, we set three specific objectives. The first goal is to increase the scientific profile of early-stage researchers. This will be reached through direct knowledge transfer and peer learning (facilitated through joint research activities, advanced training, summer-schools, and short-term mobility), and by enriching their publication portfolios with impactful scientific outputs. Furthermore, we aim at strengthening UVT’s research excellency on the chosen topic by increasing the international visibility and reputation of the early-career and mid-career researchers. This will be reached through network enriching activities (e.g., expert meetings with top scientists on the topic) and through disseminating the scientific results to the international community (e.g., presentations at international conferences and publications in international We direct our effort towards a better understanding of the learning mechanisms through which people react less adaptively. The focus will lay on how neuroticism shapes evaluative conditioning or attribute conditioning, two classes of conditioning whose relationship with neuroticism is still unclear. Based on this research, we aim to gather more cues to explain why neuroticism is considered a risk factor for emotional problems.

Keywords: conditioning,evaluative conditioning,neuroticism,experimental clinical psychology,personality
Cereal yield response to climate change in key grain producing areas of the Northern Hemisphere (CLIMRES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 219312.0
EU funding (EUR): 219312.0
Participants: 1
Project status: CLOSED

Vulnerability mapping is a field of increasing importance as we search for an ecologically and economically sustainable climate smart land use system, which is necessary for the development of green infrastructure and agricultuVulnerability mapping is a growing field with an increasing importance in developing an ecologically and economically sustainable climate smart land use system, which may serve the advancement of green infrastructure and agricultural production. The transformation of the climatic regime has an undeniable impact on plant production, but we rarely have long enough data series to scrutinise the unfolding effects of the microregional patterns of global climate-cereal yield relationship. To fill this gap, I will analyse three regions of the Northern Hemisphere under continental climate, which represent key landscapes concerning global food production and security, contributing a multi-way knowledge transfer through training, teaching and different form of communication activities. The relationship between climate indices, maize and wheat yields will be analysed applying high geographical resolution data from Northern China, Hungary and northern states of the US Midwest at a landscape scale by Köppen-Geiger zones using linear, local and spatial regression and bootstrap resampling tests and developed data visualisation techniques. This offers a unique opportunity to comparatively analyse the differences in climate-cereal yield associations by landscape types and regions. The expected results will provide highly supportive factors for planning and managing an ecologically and economically sustainable land use system. The intended publications, lectures and collaborative actions will have a positive impact on domestic and EU research. The planned training and the expected results of the action will further strengthen my career opportunities and put me in a position where I will be considered for a tenured position at a research institution in Hungary.

Keywords: wheat,maize,northern china,north america,cereal yield stagnation,climate warming,climate sensitivity,food security,grain yield impact,temperature cereal yield association
Restriction of HIV and coronavirus infections by the innate immunity protein Shiftless (RIBOSFL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

Programmed ribosomal frameshifting (PRF) is a mechanism of recoding that allows synthesis of multiple proteins from the same mRNA by shifting the translation reading frame. Many viruses, including medically important HIV and coronaviruses rely on PRF to increase their coding capacity and modulate appropriate stoichiometric ratios of viral proteins. An interferon-inducible restriction factor Shiftless (SFL) can block the frameshifting required for viral translation and infectivity. Understanding the mechanism of action of SFL will undoubtedly guide the design of new antiviral therapeutics. However, most structural and functional aspects of SFL and its role in viral infections are unknown. We intend to characterise the role of SFL in HIV and coronavirus infections using a three-pronged approach: (i) We will elucidate the mechanism of inhibition of PRF on viral mRNAs by SFL using a state-of-the-art in vitro reconstituted translation system and depletion/deletion of SFL in human cell lines. (ii) We will determine the interaction of SFL, translating ribosome and frameshifting viral mRNAs using cryo-electron microscopy. (iii) Based on the structural data obtained, we will generate mutants of SFL and characterise their activities by in vitro and cellular translation assays to identify specific domains and amino acid residues required for the antiviral activity of SFL. The results expected from our proposed study should not only be crucial for understanding the molecular mechanism of SFL but should also provide vital inputs to the development of antiviral therapeutic agents by either mimicking or upregulating SFL expression against critically important viruses such as HIV and SARS-CoV-2. Importantly, our research should continue to be relevant for the treatment of any future frameshifting virus.

Keywords: protein synthesis,ribosome,frameshifting,viral translation