Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Public Administration and Technology (PATECH)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-29
End date: 2019-05-28
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

Digital technologies are in the centre of the ongoing industrial revolution that is bound to change not only markets, but also societies and governments. Central to these developments is the evolution of public sector technological capacities, that is, an ability of public organizations to explore, develop and/or adapt new technological solutions in public service design, delivery and evaluation. One of the central questions that has so far fallen in between different research strands is how technology affects the evolution of work organization and administrative capacities in public sector. In the context of increasing dependence on technological developments, and thus, related opportunities as well as uncertainties and risks, the conventional public administration accounts fall short in fully grasping the influence of technology on public sector change. The research objectives of the project are to: a) develop a coherent and novel conceptual framework on public sector technological capacities and provide novel and empirically grounded explanations on the co-evolutionary development mechanisms of public organizations and technology through comparative cross-country analysis. In order to map and understand different co-evolutionary patterns, the project will use a comparative approach by studying two different fields (with high and low/moderate level of technological complexity) in two different small states (in an advanced (Belgium) and less advanced (Estonia) socio-economic contexts).

Keywords: public administration and technology,public sector innovation,organizational change,public sector change,technological capacity,evolutionary economics,institutional theory
Development of alga-based photovoltaic devices: Electron transport from photosynthesis via the cell wall to electrodes (EnergUP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Hungary
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2023-07-30
Duration (months): 24.0
Total project cost (EUR): 139850.88
EU funding (EUR): 139850.88
Participants: 1
Project status: SIGNED

The aim of the EnergUP project is to substantially improve the efficiency of the alga-based photovoltaic devices and thereby to contribute to the development of a climate-neutral technology. We will apply various strategies to enhance the current production by photosynthetic organisms using bio-photo electrochemical cells (BPEC). We seek for sustainable solutions without the usage of toxic chemicals or invasive cell treatments. In our experimental photovoltaic device, the electric current is transferred form the cells towards the electrode by a soluble electron mediator molecule. The electric current production of the cells is strongly limited 1) by the donation of electrons from algal cells towards the meditator molecule, 2) by the diffusion capacity of the mediator molecule through the multi-layer cell wall and 3) by the distance between the cells and the electrode surface. In this project, we will use two evolutionarily different alga species, the prokaryotic cyanobacteria, Synechocystis sp. PCC 6803 and the eukaryotic green algae, Chlamydomonas reinhardtii that are both excellent model organisms to study photosynthetic energy conversion. We will study 1) the contribution of the linear and the alternative photosynthetic electron transport pathways to the reduction of the mediator molecule by employing a range of photosynthetic mutants, and 2) the limiting effect of the cell wall on the diffusion of the mediator molecule by biochemical removal of specific cell wall layers and by employing cell-wall mutants. For the experiments, we will develop a specific measuring cuvette allowing photosynthetic activity measurements in the BPEC. We will also establish immobilization for alga-based photovoltaic devices, ensuring a close distance between the cells and the electrode surface, thereby enabling a more efficient electron transfer. Another advantage of this approach is that changing the culture media and removal of the cells from the BPEC becomes more economical.

Keywords: photovoltaics,bioenergy,current production,bio photo electrochemical cell,photosynthetic electron transport
Biomechanical Stimulation based on 4D Printed Magneto-Active Polymers (4D-BIOMAP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Spain
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-01-01
End date: 2025-12-31
Duration (months): 60.0
Total project cost (EUR): 1499625.0
EU funding (EUR): 1499625.0
Participants: 1
Project status: SIGNED

MAPs are polymer-based composites that respond to magnetic fields with large deformation or tuneable mechanical properties. I aim to apply heterogeneous 3D printed MAPs as modifiable substrates to support biological structures which can have their deformation state and stiffness controlled by the external application of magnetic stimuli. Such mechanical stimulation has an important role on biological structures leading to alterations in functional responses, morphological changes and activation of growth or healing processes. Current bottlenecks preventing progress in this field are a lack of: a) appropriate experimental methodologies to enable characterisation of the behaviour of these materials; b) fundamental theoretical underpinnings to support the design and application of these new materials. The first step is to undertake in depth characterisation and assessment of 4D printed MAPs to create a detailed understanding of the underlying physics controlling the interactions between the polymeric matrices and embedded magnetic particles during application of mechanical and/or magnetic loadings. I will then culture biological structures on the novel 4D printed MAPs to create a ‘designed’ biostructure with specified and controllable responses to a given magnetic stimulus. These novel biostructures will be assessed using three applications: a) astrocyte cellular networks, b) neuronal circuits and c) astrocyte-neuronal networks. The evaluation of cellular damage, morphological and physiological alterations will validate the performance of the new biostructures and also contribute new understanding to the effects of deformation and stiffness gradients during glial scarring on physiological functions of central nervous system cells. The resulting deep understanding of magneto-mechanics of MAPs and their further development for controllable stimulation devices, will enable the international consolidation of my research group within the mechanics and bioengineering fields.

Keywords: magneto active polymers,constitutive modelling,finite element method,4d printing,biomechanics,mechanical behaviour,biological stimulation,neuron mechanics,magnetoelasticity,solid mechanics
Management Accounting and CReativity: Analysis of MEanings (MACRAME)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2020-09-30
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

MACRAME project aims at discovering the meanings that inform management accounting practices in the Creative and Cultural Industries (CCIs). The CCIs are an increasingly relevant economic sector, with high potential of growth, innovation and social inclusion. The European Commission, especially through the Creative Europe framework programme, is investing to unlock such potential. MACRAME aims at contributing to the European strategy by providing an original and innovative interpretation of the peculiarities of creative organizations, and, in particular, of the management technologies and skills used to account and control for creative processes and outputs. The research adopts an inductive case research strategy for theory building. First, a within case analysis will be made through a fieldwork in a partner organization in the CCIs, with the aim of uncovering and interpreting the contextual role of management accounting practices in a creative setting. Second, a cross-case comparison will be made, by analyzing and comparing field materials collected by the researcher during the project and during two previous stages of fieldwork in the CCIs. From the cross-case comparison, a general theorization of the meanings of management accounting in creative settings will be provided. The research project, which will last 24 months, will mainly be conducted at the Department of Operations Management (DOM) of the Copenhagen Business School (CBS), under the supervision of Professor Jan Mouritsen, while the fieldwork will be conducted during the secondment period in a partner organization. MACRAME results will be disseminated and the action communicated with tailored measures to a wide audience, including the academic community, the industry, policy makers and the general public.

Keywords: management accounting,cultural and creative industries
Muon campus in US and Europe contribution (MUSE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Italy,Italy,Italy,Greece,United States,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2015, 2015)
Start date: 2016-01-01
End date: 2019-12-31
Duration (months): 48.0
Total project cost (EUR): 1732500.0
EU funding (EUR): 1732500.0
Participants: 8
Project status: CLOSED

The Muon Campus at FNAL, USA, will host in the next few years two world class experiments dedicated to the search for signals of new physics. Muon g-2 will determine with unprecedented precision the anomalous magnetic moment of the muon while Mu2e will improve by four orders of magnitude the sensitivity on the search for the as-yet unobserved Charged Lepton Flavour Violating process of a neutrinoless conversion of a muon to an electron. European research institutions have a leading role in both detector development and construction and in the calibration and analysis of the data. The results from the FNAL experiments will complement those from similar CLFV searches being carried out in Europe and will produce very fruitful collaborations in this field. Through an involvement in both the US and the European programmes European institutes will be at the forefront of the search for evidence of new physics in the muon sector. The goal of this proposal is to establish new collaborations among European groups participating in the Muon Campus activities and to strengthen the already existing partnership with FNAL. State-of-the-art detectors will be designed, built, commissioned. The Mu2e crystal calorimeter will provide unprecedented timing performance for low energy electrons in the presence of a strong magnetic field exploiting solid state photosensors and the Mu2e high-purity germanium detector will record X-rays at rates and in radiation levels surpassing previous experiments. The Muon g-2 straw-tracking system will measure the muon beam profile with an accuracy in the vertical plane of better than 10 mrad and will efficiently identify pileup and lost-muon events. A laser monitor system will be a common effort of the two experiments, with the need for Muon g-2 to reach an accuracy at the sub-per mil level. The existing EU infrastructures for testing radiation hardness and characterizing the detector components will make the European contribution significantly stronger

Keywords: anomalous magnetic moment of the muon,charged lepton flavour violation,particle detectors,crystal calorimeter,silicon photosensors,fpga,laser calibration systems,tracking,straw tubes
Effects of Prenatal Exposure to Acrylamide on Health: Prospective Biomarker-Based Studies (CHIPS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Sweden,Denmark
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-07-01
End date: 2025-06-30
Duration (months): 84.0
Total project cost (EUR): 1499531.0
EU funding (EUR): 820366.74
Participants: 3
Project status: SIGNED

Background: Acrylamide is a chemical formed in many commonly consumed foods and beverages. It is neurotoxic, crosses the placenta and has been associated with restriction of fetal growth in humans. In animals, acrylamide causes heritable mutations, tumors, developmental toxicity, reduced fertility and impaired growth. Therefore, the discovery of acrylamide in food in 2002 raised concern about human health effects worldwide. Still, epidemiological studies are limited and effects on health of prenatal exposure have never been evaluated. Research gaps: Epidemiological studies have mostly addressed exposure during adulthood, focused on cancer risk in adults, and relied on questionnaires entailing a high degree of exposure misclassification. Biomarker studies on prenatal exposure to acrylamide from diet are critically needed to improve exposure assessment and to determine whether acrylamide leads to major diseases later in life. Own results: I have first authored a prospective European study showing that prenatal exposure to acrylamide, estimated by measuring hemoglobin adducts in cord blood, was associated with fetal growth restriction, for the first time. Objectives: To determine the effects of prenatal exposure to acrylamide alone and in combination with other potentially toxic adduct-forming exposures on the health of children and young adults. Methods: Both well-established and innovative biomarker methods will be used for characterization of prenatal exposure to acrylamide and related toxicants in blood from pregnant women and their offspring in prospective cohort studies with long-term follow-up. Risk of neurological disorders, impaired cognition, disturbed reproductive function and metabolic outcomes such as obesity and diabetes will be evaluated. Perspectives: CHIPS project will provide a better understanding of the impact of prenatal exposure to acrylamide from diet on human health urgently needed for targeted strategies for the protection of the health.

Keywords: epidemiology,diet,prenatal exposure,biomarkers
Advancing cancer detection through metabolism-based diagnostics (AURORAX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-05-01
End date: 2022-12-31
Duration (months): 44.0
Total project cost (EUR): 3346674.0
EU funding (EUR): 2342671.0
Participants: 1
Project status: CLOSED

Former cancer patients receive regular follow-ups to detect recurrences at early stages and optimize treatment outcomes. The follow-up frequency is currently limited by costs and radiation risks of imaging approaches used to surveil for recurrences, resulting in recurrences being detected too late – often resulting in terminal disease. Of the 139.000 annual Renal Cell Carcinoma (RCC) patients, 20% are diagnosed with a metastatic recurrence within 5 years after surgery. Once metastatic, RCC survival rates drop to 12% over 5 years survival. Elypta, Sweden, has developed the first metabolism-based liquid biopsy to detect early-stage recurrences. The quantification of a metabolite signature in blood or urine and an algorithmic analysis allows for exceptional sensitivity, a low cost of the platform and significantly improves on imaging approaches in cost and risk, enabling frequent patient follow-up. Elypta’s technology has been demonstrated in small clinical trials and its cost effectiveness assessed by two independent companies. Elypta’s platform is easily scalable to other cancer indications and applications such as treatment monitoring, as demonstrated in multiple small trials. Starting in the niche RCC market with limited competition, Elypta now requires clinical evidence for a product launch within RCC. The business strategy focuses on distribution and sales through clinical laboratories, which will benefit financially off sales. During the AURORAX, Elypta will 1) perform a clinical validation trial (AUR87A) to generate strong clinical evidence, 2) obtain regulatory clearance in the EU and the US and 3) introduce the product for research use only (RUO) and after clinical validation enter the RCC diagnostics market in EU. As users of the platform, oncologist and urologists have all signed letters of support. A pharmaceutical partner has also signed a letter of support, expressing their interest in RUO use of the platform, providing a solid basis in the emerging liquid biopsy market (€200B market).

Keywords: in vitro diagnostics,oncology,urology
Global measure of biodiversity by understanding biogeochemical cycling of environmental DNA in lakes (LeDNA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Switzerland
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-03-01
End date: 2025-02-28
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

The global loss and redistribution of biodiversity is a hallmark of the Anthropocene. Our challenge is to generate information about how altered biodiversity influences ecosystems and use this information to change our impact on the biosphere. To meet this challenge, we must know where species are, how their distributions change in time and why. However, current methods for determining species distributions is expensive, time intensive and hard to do for multiple species and large geographic regions- rendering global trend analysis near infeasible. We therefore need a paradigm shift. I will utilize the biotechnology of the fourth industrial revolution (i.e., inexpensive sequencing and computational power) to empirically change how we sample animal and plant biodiversity to solve the infeasibility problem of tracking multiple species distributions on large spatial scales. I am among the first to show that DNA shed from animals into the environment (‘eDNA’) is transported in rivers (10-12 km) and that it is from aquatic and terrestrial species. Building on these observations, I hypothesize that transported eDNA allows for sampling multiple species on large spatial scales and will test my hypothesis by determining if lakes act as accumulators of eDNA in the landscape by receiving transported eDNA from rivers. Thus, my proposed research will investigate (1) how chemical, physical, and biotic processes cause eDNA decay to understand its transport potential in the environment, (2) how much eDNA from a catchment is transported into a lake, and (3) in a global set of lakes, test whether eDNA measures seasonal turnover of biodiversity for large spatial scales. If lakes accumulate eDNA from their catchments, sampling them will provide the paradigm shift needed to vastly change the cost, speed and geographic scale with which species can be surveyed through time to understand what effect their change has on the biosphere.

Keywords: environmental dna,animals and plants,metabarcoding
Evidence-based probiotic for Chronic Fatigue Syndrome (Help4ME)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-04-01
End date: 2019-09-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Let’s imagine being tired to the point where any activity causes weeks of weakness and pain. Common noises and daylight become an unbearable torture and a “brain fog” doesn’t let you think clearly. In spite of the tiredness, you wake up without being refreshed, if you can fall asleep at all. Days pass as well as doctors check-ups, and no one is able to tell you what is wrong. Finally, after few years of trying to pull yourself up, the answer is Chronic Fatigue Syndrome (CFS). Happy of the fact of being diagnosed, you quickly learn that it means that there are no measures able to cure you and chances of full recovery are only 5%. Indeed, the reality of CFS patients’ life is tough and contrary to many beliefs it is not a rare disease. The world count of diagnosed CFS is estimated for up to 24 million cases and considered to be only 10% of the whole CFS population. Although frequently triggered by infection, cause of CFS is not yet known. Researches look for its source in the guts, which are inhabited by billions of microorganisms and form a complex ecosystem with profound impact on the whole body. Imbalance of gut microflora, damaged gut barrier functions and dysfunctional immune responses are known in CFS and shared with another disease - Irritable Bowel Syndrome (IBS), which frequently accompany CFS. GutMagnific™ is an evidence-based probiotic scientifically designed and shown to be effective in correcting the gut microflora disbalance – a source of CFS and IBS symptoms. The novelty of the product lies in the unique combination of 5 lactobacilli strains with evidence-based efficacy and shows a life-changing promise to severely underserved population of CFS patients.

Keywords: probiotic,lactobacilli,chronic fatigue syndrome