Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development and Pilot Line Validation of a Modular re-configurable Laser Process Head (ModuLase)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Germany,Spain,Italy,Belgium,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Photonics Laser-based production (H2020-FOF-2016, 2016)
Start date: 2016-09-01
End date: 2021-05-31
Duration (months): 57.0
Total project cost (EUR): 2405924.29
EU funding (EUR): 2184565.0
Participants: 8
Project status: CLOSED

State-of-the-art fibre-delivered laser sources are an industrially accepted tool for performing a range of materials processing applications. Despite the unrivalled capability of fibre-delivered laser sources to perform a wide range of processes, the potential flexibility of the laser source is limited by the need to change the processing head for these processes to be performed. The majority of industrial laser systems are employed to perform low-variety and high-volume manufacturing operations. However, current manufacturing trends (such as increased automation, individualisation and next-shoring) are driving the need to develop manufacturing systems which are capable of performing a higher variety of manufacturing operations. The ModuLase project will develop a re-configurable highly flexible processing head system, which will be capable of covering welding, cladding and cutting. The ModuLase process head system will: • Be capable of welding, cladding and cutting, through the use of three modular end-effectors • Include intelligent sensor technologies for in-process monitoring • Be linked to an intelligent system, in order to achieve adaptive process control, quality assurance, and semi-automated process parameter configuration. The development and pilot line validation of the ModuLase laser process head will unlock the potential flexibility of fibre-delivered laser sources, and address a number of arising industrial challenges; including: • An increasing need for flexible manufacturing systems to support an increasing variety of product mixes. • The need to maximise equipment utilisation rates, by eliminating down-time associated with changing of laser processing heads and equipment stoppages. • Reducing capital investment costs.

Keywords: laser welding,laser cutting,laser cladding,end effector
Non-local dynamics in incompressible fluids (NONFLU)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-09-01
End date: 2024-08-31
Duration (months): 72.0
Total project cost (EUR): 1779369.0
EU funding (EUR): 1779369.0
Participants: 1
Project status: SIGNED

The goal of this project is to pursue new methods in the mathematical analysis of non-local and non-linear partial differential equations. For this purpose we present several physical scenarios of interest in the context of incompressible fluids, from a mathematical point of view as well as for its applications: both from the standpoint of global well-posedness, existence and uniqueness of weak solutions and as candidates for blowup. The equations we consider are the incompressible Euler equations, incompressible porous media equation and the generalized Quasi-geostrophic equation. This research will lead to a deeper understanding of the nature of the set of initial data that develops finite time singularities as well as those solutions that exist for all time for incompressible flows.

Keywords: global existence,singularities,partial differential equations,incompressible fluids,harmonic analysis
Optimal transport techniques in the geometric analysis of spaces with curvature bounds (CURVATURE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: United Kingdom,United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-02-01
End date: 2024-12-31
Duration (months): 71.0
Total project cost (EUR): 1256221.0
EU funding (EUR): 1178128.38
Participants: 2
Project status: SIGNED

The unifying goal of the CURVATURE project is to develop new strategies and tools in order to attack fundamental questions in the theory of smooth and non-smooth spaces satisfying (mainly Ricci or sectional) curvature restrictions/bounds. The program involves analysis and geometry, with strong connections to probability and mathematical physics. The problems will be attacked by an innovative merging of geometric analysis and optimal transport techniques that already enabled the PI and collaborators to solve important open questions in the field. The project is composed of three inter-connected themes: Theme I investigates the structure of non smooth spaces with Ricci curvature bounded below and their link with Alexandrov geometry. The goal of this theme is two-fold: on the one hand get a refined structural picture of non-smooth spaces with Ricci curvature lower bounds, on the other hand apply the new methods to make progress in some long-standing open problems in Alexandrov geometry. Theme II aims to achieve a unified treatment of geometric and functional inequalities for both smooth and non-smooth, finite and infinite dimensional spaces satisfying Ricci curvature lower bounds. The approach will be used also to establish new quantitative versions of classical geometric/functional inequalities for smooth Riemannian manifolds and to make progress in long standing open problems for both Riemannian and sub-Riemannian manifolds. Theme III will investigate optimal transport in a Lorentzian setting, where the Ricci curvature plays a key role in Einstein's equations of general relativity. The three themes together will yield a unique unifying insight of smooth and non-smooth structures with curvature bounds.

Keywords: optimal transport,differential geometry,metric geometry,metric measure spaces,ricci curvature,isoperimetric inequalities,sectional curvature,alexandrov spaces,lorenzian geometry
An intersectoral innovative solution involving DIGItal tools, empowering families and integrating community CARE services for the prevention and management of type 2 diabetes and hypertension (DigiCare4You)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Methods and data
Action type: Research and Innovation actions
Countries involved: Albania,Spain,Italy,Australia,Italy,Belgium,Belgium,Bulgaria,Greece,Greece,Greece,France,United States,Netherlands
Call: Implementation research for scaling up and transfer of innovative solutions involving digital tools for people-centred care (H2020-SC1-2020-Two-Stage-RTD, 2020)
Start date: 2021-04-01
End date: 2025-09-30
Duration (months): 54.0
Total project cost (EUR): 4408368.75
EU funding (EUR): 3972161.25
Participants: 18
Project status: SIGNED

DigiCare4You Consortium will jointly work with local stakeholders to deliver an intersectoral innovation involving digital tools for early screening, prevention and management of type 2 diabetes (T2D) and hypertension (HTN). An implementation study will be conducted, targeting more than 10,000 families in two Middle Income Countries (Albania and Bulgaria) and two High Income Countries (Greece and Spain), considering vulnerable groups. Schools will be used as an entry point to the community and building on an existing procedure for children’s periodic growth assessment (conducted via school nurses or in collaboration with local community health centres), parents/ caregivers will be screened via a non-invasive self-reported digital screening tool. Those identified at high risk for T2D will be referred for glycaemia testing and blood pressure (BP) measurements at local community health centres. Parents/ caregivers confirmed to have pre-diabetes or diabetes (and possibly high BP) will be invited to join a mHealth self-management intervention coordinated by the community healthcare workforce. The goal of this intervention is not only to improve the health status of the users, but also empower the entire family in adopting a healthy lifestyle. To this end, schools and communities will also be actively engaged to promote health literacy, well-being and support lifestyle changes creating a more supportive social and physical environment for the entire community. Regular monitoring will be ongoing during the implementation to allow corrective actions and ensure effective adaptation and uptake. Based on the study outcomes, the in-depth health economic evaluation and budget impact analysis, and data deriving from a Scalability Assessment and Decision-Support tool, national and international stakeholders will be invited to evaluate, through a series of webinars and workshops, the scalability potential of the DigiCare4You solution in other regions or countries in Europe.

Keywords: community,primary healthcare,families,m health application,diabetes,hypertension,screening,lifestyle intervention,self management,people centred care,scaling up
Single cell profiling of breast tumors and the residing immune cells leveraged by integration with multi-dimensional molecular data from thousands of tumors (SCISSORS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2022-12-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

Breast cancer is the most common type of cancer in Europe, responsible for the highest women cancer mortalities each year. Characterisation of breast tumours teased them apart to distinct subtypes and facilitated targeted treatments that improved survival rates significantly, yet some aggressive subtypes remain difficult to treat. New therapies that harness the patient own immune system to fight the tumour show remarkable success in several cancers but limited one in breast cancer. Single cell genomics is the cutting-edge method to profile tissues at the highest resolution. As a computational biologist experienced in this technique, I will use it to analyse breast tumours with their residing immune cells. I aim to dissect the dynamic processes that shape the clonal development of the tumour as it emerges from a healthy tissue, with an emphasis on the immune system response to the evolving tumour. Single cell genomics, being the main driving tool, will be leveraged by integration with vast data from thousands of deeply profiled tumour samples available in the Host lab. The project includes generation of a healthy breast single cell expression atlas; a computational method to infer somatic mutations clones from single cell genomics data; single cell profiling of breast tumours together with adjacent normal tissues; and lastly, integration of the results with data from the large tumours biobank that holds years of clinical history which may reveal new progression markers and improve risk stratification. This plan is unique by accounting for multiple aspects of the tumours, including normal to malignant transition, interplay of breast and immune cells, and tumour clonal dynamics. By tackling common cancer immune mechanisms, it may provide novel insights of relevance to all cancer types. Pursuing this grand project in a leading lab that covers all aspects of breast cancer research will increase my research versatility on my way to become an independent researcher.

Keywords: breast cancer,single cell transcriptomics,comparing tumors and adjacent normal tissue,immunotherapy,dysfunctional t cells,somatic mutation clones,single cell multiomics
Eco-friendly food packaging with enhanced barrier properties (BIOCOMPLACK)

Framework: Horizon 2020 — Societal Challenges
Action type: Innovation actions
Countries involved: Italy,Spain,France,Netherlands
Call: Fast Track to Innovation Pilot (H2020-FTIPilot-2015-1, 2015)
Start date: 2016-06-01
End date: 2019-05-31
Duration (months): 36.0
Total project cost (EUR): 2735212.5
EU funding (EUR): 2023425.0
Participants: 6
Project status: CLOSED

BIOCOMPLACK is a biobased, biodegradable and compostable food packaging with enhances barrier properties. BIOCOMPLACK is a food biopackaging with three main points of innovation: the use of cellulose nanocrystals (CNCs), the multilayer structure and the PLA biopolymer reinforced with organoclays which contain natural food preservatives. These three innovations will enhance the barrier properties to oxygen (more than 100 times compared with common biopackaging) and water vapour as well as will improve the shelf-life of food. BIOCOMPLACK is an alternative to common bio-packaging products that enhances 300% the shelf-life of food. This international project is born in a consortium integrated by two large enterprises (Sapici and Goglio), two small-medium enterprises (SMEs) (NaturePlast and Tecnopackaging) and a research institution (Packlab, University of Milan) from four different countries which together cover the supply chain of the food packaging industry. BIOCOMPLACK will have strong impact in the society and in the environment. BIOCOMPLACK will be an eco-friendly packaging from natural renewable sources instead of fossil fuels, will reduce the plastic packaging waste thanks to its biodegradability in the nature and will generate at the end of its useful life an added value product, the compost (to improve the quality of soils and provide nutrients). Our BIOCOMPLACK solution will provide a loop cycle of sustainability. European Union will be also impacted by BIOCOMPLACK because it will make a substantial contribution to innovation in the European economy, will reduce the import of biopackaging from outside the EU and we will export at international level. This consortium will also be benefited by bringing into the market the BIOCOMPLACK food packaging in 36 months. The profitability of the project presents for the first 5 years a ROI of 2.47 and the pay-back of the project will be achieved after 2 years and 9 months after the beginning of the commercialization

Keywords: biopackaging,biofilm,barrier properties,long term food preservation,cellullose nanocrystals
Evolutionary Stability of Ubiquitous Root Symbiosis (HeteroDynamic)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-04-01
End date: 2022-03-31
Duration (months): 72.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

Virtually all terrestrial plants depend on symbiotic interactions with fungi. Arbuscular mycorrhizal (AM) fungi evolved over 450 million years ago, are obligate biotrophs and cannot complete their lifecycle without obtaining carbon from host roots. Mediating nutrient uptake and sequestering carbon in soil this symbiosis lie at the core of all terrestrial ecosystems. Plants on the other hand are facultative mycotrophs but under natural conditions all host roots are colonized as a result of multiple beneficial effects of AM fungi. In the symbiosis, both plants and fungi are promiscuous, forming interactions across individuals and species. In the absence of host-symbiont specificity and given their inability to discriminate among partners prior to interaction, evolutionary theory predicts that “free riders” would evolve and spread. Yet AM fungi remain evolutionary and ecologically successful. I propose that this is thanks to their unique genomic organization, a temporally dynamic heterokaryosis. Unlike other eukaryotes, AM fungi have no single nucleate stage in their life cycle, instead they reproduce asexually by forming large multinucleate spores. Genetic variation is high and nuclei can migrate and mix within extensive mycelial networks. My group has recently established a single nucleus genomics method to study genetic variation among nuclei within AM fungi. With this method I can resolve the extent of heterokaryosis in AM fungi and its temporal dynamics. I will study the emergence of “free riders” upon intra organismal segregation of genetically distinct nuclei during AM fungal adaptation to host. Further I will study how hyphal fusion and nuclear mixing counteract segregation to stabilize the symbiosis. The research program has great potential for novel discoveries of fundamental importance to evolutionary and environmental biology and will also contribute to agricultural practice and management of terrestrial ecosystems.

Keywords: symbiosis
Neuronal and dendritic recruitment on neocortical area borders (DENDRITESONBORDERS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

One of the most striking features of cortex is the elaborate and electrically active dendritic arbors of its neurons. Besides serving as a scaffold for synaptic inputs, dendrites can amplify inputs and act as computational subunits within a neuron. However, the principles governing the relationship between dendritic processing and information flow through cortical networks remain to be elucidated in vivo. These basic principles must be discovered as part of the effort to generate useful theories that relate sub-cellular processes like synaptic integration to computations performed by large populations of neurons. Such theories that link different scales of neural function are an important step for the larger scientific and societal goal to interpret, predict and manipulate neuronal and cortical function in health and disease. We seek to uncover principles describing the relationships between local network activity, dendritic recruitment, and neuronal output in neocortex in vivo in the anatomical context of a visual cortical area border in the mouse brain. Cortical area borders are poorly understood, but offer unique experimental opportunities. Our goal is to exploit the functional asymmetry present at borders to perform strong experiments that ask: Do functionally similar inputs cluster in dendritic arbors? How is the recruitment of individual dendrites related to local network activity? Do different dendritic branches perform separable computational operations in vivo? Going further, we will determine if different streams of information are segregated or integrated at borders. This basic feature of cortex is interesting both computationally and developmentally. The answers will speak to the constraints faced by cortex in managing information flow and creating functional specialization. We hope the innovative approach of leveraging the unique features of an understudied anatomical special case will yield results and a perspective that is original and useful.

Keywords: cortex,neural circuits,dendritic integration,visual system,calcium imaging
Coding for terabit-per-second fiber-optical communications (TERA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Sweden,United States
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2020-03-31
Duration (months): 36.0
Total project cost (EUR): 265059.0
EU funding (EUR): 265059.0
Participants: 2
Project status: CLOSED

The goal of this project is to improve the performance and efficiency of fiber-optic communication systems that operate at terabit-per-second data rates. This goal will be realized by analyzing and optimizing the error-correcting codes used by these systems. Our first objective is to derive a finite-length scaling law which characterizes the code performance as a function of the code length (in bits). As a major novelty, we consider deterministic codes, which can fulfill the stringent requirements of terabit-per-second systems in terms of target bit error rates and hardware implementation. A scaling law can be used, for example, to rapidly assess the code performance in order to identify trade-offs and optimize system parameters. It thus constitutes a fundamental tool in order to design next-generation systems and to further push the limits of fiber-optic data transport. Our second objective is to reduce the decoding complexity. Current algorithms waste resources (power) because they do not exploit valuable information that is exposed during the decoding process. We minimize complexity by designing efficient component code selection strategies. We will also theoretically analyze the expected complexity savings, in particular in the regime where the noise level approaches the code’s threshold. The development of low-complexity decoding algorithms plays an important role in the design of energy-efficient fiber-optic systems decoding contributes substantially to the overall energy consumption. Therefore, this work will help to ensure that future data traffic demands can be met in a sustainable way. Our results are broadly applicable also for Flash memory systems, vehicular communication networks, and the computation of sparse fast Fourier transforms.

Keywords: error correcting codes,fiber optic communications,finite length scaling,low complexity decoding