Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Beyond submerged landscapes - defining human response to postglacial sea-level rise and climate change (SUBNORDICA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Denmark,Belgium,Netherlands,United Kingdom
Call: ERC Synergy Grants (ERC-2023-SyG, 2023)
Start date: 2024-04-01
End date: 2030-03-31
Duration (months): 72.0
Total project cost (EUR): 13221969.0
EU funding (EUR): 13221969.0
Participants: 8
Project status: SIGNED

The landscapes that extended for millions of square kilometres offshore of the world’s coastlines due to low sea-level during the last glaciation and were then drowned by sea-level rise, are known to preserve valuable archives of landscapes, palaeoclimatic change and stratified archaeological remains, with the potential to transform understanding of human history in this period of dramatic change. The absence of archaeological sites across much of this vast area prevents realisation of this potential. In SUBNORDICA we propose a systematic approach to develop new methods for recreating the submerged landscapes and human settlement of NW Europe and assess the impact of postglacial sea-level rise. We will address two questions: (1) What changes to the topography and environment of the submerged landscape were brought about by rising sea level and climate change? (2) How was the distribution of archaeological settlements and other traces of cultural activity impacted by this changing palaeolandscape, and can we recover them in sufficient detail to investigate human impact and human response? Combining information from 4 regions in the southern North Sea and the southern Baltic, we will use artificial intelligence to develop machine-learning routines to (a) integrate existing and newly acquired geophysical and geological data to map key areas of the changing landscape, and (b) combine this information with data from known underwater archaeological sites to identify new targets of archaeological potential for more detailed investigation. Investigating these targets will use high-resolution geophysical methods, sediment coring, archaeological excavation, and geochronological, palaeoenvironmental, sedimentological and biological analyses of recovered deposits. We will reveal a new chapter in human prehistory, provide a world-leading model for the investigation of submerged landscapes, and offer improved policy guidance for underwater cultural heritage management.

Keywords: submerged landscape archaeology
Proglacial lake impacts on the export of Organic carbon and Nutrients to Downstream ecosystems (POND)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 251578.56
EU funding (EUR): 251578.56
Participants: 2
Project status: SIGNED

Glacier retreat is accelerating in response to climate warming, leading to an increase in the number and total area of proglacial lakes globally. Proglacial lakes have the potential to modulate glacial runoff via sediment immobilization and in-lake biogeochemical cycling, with implications for the productivity and biodiversity of valuable downstream ecosystems. However, a quantitative understanding of the impact of proglacial lake modulation on the export of glacier-derived suspended sediment (SS), nutrients and organic carbon (OC) is currently lacking. POND will fill this critical knowledge gap by quantifying relationships between proglacial lake physical characteristics and changes in riverine fluxes of SS, nutrients and OC in rapidly deglaciating landscapes in Norway using a combination of remote sensing, field sampling, and biogeochemical analyses. Results will be used to inform a novel and globally relevant conceptual model of proglacial lakes as 'biogeochemical modulators' of glacial runoff. POND will be hosted at UiT the Arctic University of Norway, facilitating unrivaled low-carbon impact access to Arctic and temperate glacial field sites. This highly interdisciplinary project unites my track record in glacial dissolved organic matter chemistry with UiT's expertise in glacier biogeochemical cycling and landscape evolution at regional to global sales. A secondment at the Norwegian Water Resources and Energy Directorate will facilitate access to glacier and glacial lake inventories, supporting my training in the use of remote sensing and ensuring close collaboration with a water resource management stakeholder with direct interest in POND research findings. POND's unprecedented quantitative evaluation and conceptual model of the biogeochemical impacts of proglacial lake growth on SS, nutrient and OC export to downstream ecosystems will inform future ecosystem management and policy in glacially-influenced mountain regions worldwide.
Acoustic and mechanical metamaterials for biomedical and energy harvesting applications (MetacMed)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Poland,France,Spain,United Kingdom,Switzerland
Call: MSCA Doctoral Networks 2022 (HORIZON-MSCA-2022-DN-01, 2022)
Start date: 2024-03-01
End date: 2028-02-29
Duration (months): 48.0
Total project cost (EUR): 2023236.0
EU funding (EUR): 2023236.0
Participants: 14
Project status: SIGNED

MetacMed aims to link basic research on acoustic and mechanical metamaterials (MMs) to health and well-being issues. MMs have some remarkable properties, though to make them properly applicable to the targeted applications, their design must be carefully tailored. This will be achieved by bringing together a range of supervisory expertise and creating a network of 10 doctoral candidates (DCs), some of whom will work in the industry. The team includes beneficiaries and associated partners who, if working separately, would not be able to make the planned advances in research and innovation. DCs will each consider ways in which human health can be improved using MMs, e.g. improvement in the resolution of biomedical ultrasound imaging for e.g cancer diagnostics, the design of better spinal implants, monitoring of bone healing, the use of insoles to aid human walking. Another area of interest is to develop MMs that can be used for energy harvesting, to better power e.g. medical devices and reduce reliance on conventional power sources. These are all backed up by fundamental studies into the MMs themselves to provide the background to achieve these tasks. The balance of the network has thus been carefully considered in terms of basic science and applications, with input from industry in areas such as MMs fabrication and exploitation. Associated with the above is a strong set of training events, where the basic features of acoustic and mechanical MMs and their applications will be considered, together with soft-skills training such as writing, presenting, entrepreneurship, gender balance issues, stress management. Regular meetings of the DCs at various member locations will foster collaboration, and this will be reinforced by a carefully-selected set of secondments. A proper management system for both running the network effectively and properly monitoring and supporting PhD progression is built into the proposal, ensuring that successful outcomes are achieved by DCs.

Keywords: ultrasonic and mechanical metamaterials metamaterial spinal devices health screening via metamaterials biomedical imaging acousto mechanical energy harvesting and insulation fem multi physics
Stochastic dynamics of sINgle cells: Growth, Emergence and Resistance (SINGER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2284998.0
EU funding (EUR): 2284998.0
Participants: 1
Project status: SIGNED

This project aims to introduce new stochastic and deterministic models for biological and medical applications, to analyse them mathematically, to derive qualitative properties of solutions, to quantify the emergence of asymptotic regimes and to determine the limiting equations. Motivated by recent biological experiments involving single cell observations, we emphasize the effects of very small populations in various biological/medical contexts related to evolution such as emergence of leukemia and of antibiotics resistance. Our main mathematical challenge is to quantify such effects in particular on macroscopic approximations. It is our hope that this will possibly shed some light on new therapeutic strategies. In order to track individuals and to take into account small populations, we are naturally led to stochastic multiscale models while the limiting macroscopic equations should involve nonlocal nonlinear partial differential equations (PDE) with constraints and singularities. We shall investigate in particular the impact of various time scales on macroscopic approximations of a new class of birth and death processes leading to a new class of Hamilton-Jacobi (HJ) equations with constraints and singularities. Preliminary numerical simulations indicate that these models should exhibit many surprising asymptotic behaviours such as cyclic behaviours that we shall attempt to derive rigorously. We also plan to study the lineages of sampled individuals at a given observation time by determining mathematically their time reversal paths. This issue is of particular relevance when taking into account the effect of time dependent environments, in which case the survival of individuals may only be explained by a very small number of initial individuals. One long term objective consists in imagining evolutionary scenarii of resistances and better strategies for antibiotics or chemotherapy. It will be closely developed with biologists and medical biologists.

Keywords: mathematics for evolutionary biology measure valued birth and death processes multiscale stochastic processes hamilton jacobi equations ancestral lineages time reversed trajectories environmental impacts mathematics for leukemic mutant invasion law of diagnosis hitting times growth fragmentation models modeling of bacterial response to antibiotics
Unraveling pacemaker (dys)function using novel stem cell-derived human heart models (Beat-to-Beat)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 1797105.0
EU funding (EUR): 1797105.0
Participants: 1
Project status: SIGNED

The pacemaker cells of the sinoatrial node (SAN) trigger three billion heartbeats in an average human life span. At the start of each beat, the SAN must generate enough current to drive the surrounding atrial tissue, which contains 10,000 times as many cells as the SAN itself. This extraordinary biological feat is a result of intrinsic features such as SAN tissue architecture. In addition, SAN function is modulated by extrinsic inputs from the autonomic nervous system, which adjusts the pace from beat-to-beat, for example during exercise. Any disturbances to these core activities result in SAN dysfunction, which include abnormal heart rate (brady or tachycardias), SAN exit block (lack of atrial activation) and chronotropic incompetence (inability to increase heart rate). SAN dysfunction is also a major trigger for atrial fibrillation, the most common form of arrhythmia. The goal of this ERC-StG proposal is to make significant leaps in our understanding of the intrinsic and extrinsic factors that regulate SAN function in health and disease using innovative multi cell type as well as multi organ in vitro models created from human pluripotent stem cells. The first objective is to determine the role of SAN subpopulations, particularly transitional cells in facilitating impulse propagation at the pacemaker-atrial interface by evaluating an SCN5A loss-of-function mutation. The second objective is to gain insights into the relationship between SAN-dysfunction and atrial fibrillation by assessing MYH6 variants associated with both these diseases. Lastly, the third objective will unravel how damage to autonomic function in the higher orders of the brain, for e.g., in neurodegenerative diseases such as Huntington’s disrupts electrical activity of pacemaker cells. This research will provide exquisite knowledge of the fundamental principles that regulate pacemaker function which is essential to effectively address SAN dysfunction and atrial arrhythmias.

Keywords: ipsc,cardiomyocyte,pacemaker cell,arrhythmia,atrial fibrillation,sinus node dysfunction,brain heart axis
Ottoman Sea Borders, Fortresses and Geo-political Considerations in the Eastern Mediterranean, 1699-1832 (SEABORD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Cyprus,Greece
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 164328.0
EU funding (EUR): 164328.0
Participants: 2
Project status: CLOSED

SEABORD will explore the frontier fortresses of Eastern Mediterranean in a comparative perspective in order to assign their role in defence, socio-economic development and geo-political considerations during the Ottoman rule. This research will focus on fortress-towns of Peloponnese, Cyprus and Crete, considering their similar historical trajectory in establishing Ottoman sea borders in the Eastern Mediterranean. This project will be based on a research conducted and collected qualitative data in various archives (in Istanbul, Athens, London, Vienna and Nantes), and on other primary sources, and on-site fieldwork facilitated by advanced digital tools and methods. Combining use of unpublished archival material with development of new digital reproductions (3D images, GIS based maps), this research offers an innovative approach to share and engage with cultural heritage in Europe. Main outcomes of this project will be a monograph, conference papers (will be published in edited collective volumes or as journal articles), and a digital museum, which will contribute to disseminate the project results in a wider audience. During two years period of the MSCA European Fellowship (EP), the researcher will base her research and training activities at Science and Technology in Archaeology and Culture Research Center (STARC), at the Cyprus Institute (Cyl). As part of her fellowship, she intends to complete a 3-month secondment at the Department of History and Archaeology, at the University of Crete, to enhance her training and expand her research. Overall, this project aims address a significant societal challenge, primarily resulting from derision of systematic research on such monuments during the Ottoman rule in Greece, and elsewhere in Europe in general. Thus, dissemination, communication and outreach activities are designed fulfilling this aim promoting research on fortresses and castles, and other examples of built military heritage of the Ottoman past in Europe.

Keywords: sea borders,fortresses,port towns,eastern mediterranean,ottoman empire,peloponnese,crete,cyprus
APOBEC Mutagenesis: a novel Achilles heel of Breast cancer (AMBER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2499990.0
EU funding (EUR): 2499990.0
Participants: 1
Project status: SIGNED

APOBEC mutagenesis is a cellular mechanism by which genetic alterations are acquired somatically, driven by APOBEC enzyme family members. This mechanism is prominently observed in 15% of primary and 25% of recurrent breast cancer, the most common cause of cancer-related death in middle-aged women. Current evidence suggests APOBEC mutagenesis contributes to all disease stages, i.e. cancer initiation, progression and treatment resistance. The core idea of the AMBER project is that unravelling the mechanism of APOBEC mutagenesis induction and maintenance will turn this mechanism into breast cancer’s Achilles heel. To prove this, I will answer several challenging research questions: Why is APOBEC mutagenesis operational in breast cancer? How does APOBEC contribute to disease progression? Can we target APOBEC mutagenesis or APOBEC driven tumours specifically? First, I will reveal epidemiological and molecular evidence for factors inducing APOBEC mutagenesis in breast cancer. This may help to prevent APOBEC mutagenesis from occurring, potentially decreasing breast cancer incidence. Second, using global and single cell genomics, I will secure a link between APOBEC mutagenesis and disease progression, giving leads to delay progression. Third, I will exploit a potential vulnerability of APOBEC driven breast cancer, since I have found that these tumors may depend on a proficient homologous DNA repair (HR) pathway. When experimentally confirmed, targeting HR may extinguish APOBEC driven disease. Finally, I have observed that APOBEC mutagenesis associates with a profound immune response. I hypothesize that this is due to a new type of neo-epitopes being produced. If proven true, targeting these neo-epitopes provide another effective means to eradicate APOBEC driven tumors. I am confident AMBER will provide the fundamental insights into APOBEC mutagenesis needed to turn it into an Achilles heel which may help to prevent, delay or cure APOBEC driven breast cancer.

Keywords: breast cancer,apobec mutagenesis,disease progression,tumor evolution,therapeutic strategies,immune editing
An integrated typology-based approach to guide the future development of European historic buildings towards a clean energy transition (FuturHist)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Efficient, sustainable and inclusive energy use
Action type: Research and Innovation actions
Countries involved: Italy,Sweden,Austria,Denmark,France,Germany,United Kingdom,Poland,Spain
Call: Future-proofing historical buildings for the clean energy transition (HORIZON-CL5-2023-D4-01, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 3896051.25
EU funding (EUR): 3896051.25
Participants: 18
Project status: SIGNED

The process of future proofing the built heritage faces the paradox of needing standardised approaches but having a heterogeneous stock with very specific needs. FUTURHIST will rely on the identification and characterisation of local uniform building typologies, as a lowest common denominator, to develop tailored intervention approaches that can be standardised and replicated in all buildings of that category with minor modifications. The standardised approach will then serve as a basis for the adaptation to other typologies in the same context (climate, regulations, etc.) or even similar typologies (in terms of materials, configuration, etc.) in different contexts. Although considerable progress has been done in recent years in terms of development of materials and solutions compatible with conservation of historic buildings, several challenges remain still open. FUTURHIST will develop both passive and active solutions with a focus on an efficient use of energy and resources, improved wellbeing, enhanced durability, revalorization of existing materials and techniques, integration of renewable energy systems, and smart solutions for decarbonising heating, cooling, and ventilation. Mentioned here, just as examples, be a clay-biochar-insulation, self-healing lime plaster and hybrid original-vacuum glazing. Demonstration is at the core of the project. The solutions developed as well as the approach will be implemented and tested in four cases in Spain, Poland, Sweden, and the UK. The diversity and geographical distribution of the demo cases will ensure the validation under different climates, construction typologies and socio-economic environments. The demo case owners, as members of the consortium, will facilitate a rapid uptake of the results to be implemented in their large portfolios immediately after the completion of the project. Moreover, the involvement of heritage authorities and partnership with ICOMOS and INTBAU will ensure trust and widespread replication

Keywords: standardised approach multi dimension decision making methods real life demonstrators internal insulation bio based materials window retrofit hvac res integrated pv sri