Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
NEW ADVANCED VACCINES IN CHRONIC HEPATITIS B (NAVICHEB)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-04-01
End date: 2015-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Despite effective vaccines, hepatitis B virus (HBV) infection remains a major health problem with 2 billion people infected worldwide. Among them, 350 million are chronically infected, a major risk factor for development of hepatocellular carcinoma (HCC). A new and efficient treatment against chronic infection and HCC is strongly needed, and therefore it is important to understand HBV replication and persistence. In the absence of a good model, woodchuck infection with woodchuck hepatitis virus (WHV) is used as the preferred system to study disease and by homology, HBV nature. In the present proposal we intent to establish a robust WHV reverse genetic system to study the virus replication and pathogenesis. By utilizing this WHV reverse genetic system, we plan to introduce two new strategies to generate virus-attenuated vaccines that could infect and interfere with wild type virus replication. WHV core is a structural protein required for virus replication and growth. We are proposing to construct a core deficient recombinant WHV that could replicate in wild type WHV infected cells, interfering with wild type infection. A second strategy focuses on Hepatitis B virus X (HBx) and woodchuck hepatitis virus X (WHx) multifunctional proteins, which are required for optimal HBV and WHV replication and development of WHV derived HCC. We propose to create recombinant WHV with a mutant WHx protein that will interfere with full-length protein activities if they are co-expressed. As an initial approach to study virus replication, we will utilize woodchuck hepatocyte xenograft transplants in RAG-1 transgenic mice. Finally, woodchuck animal model will be challenged to test the efficacy of recombinant viruses replication and interference with chronic infection and suppress HBV derived HCC. Our ultimate goal is to develop novel effective molecular therapeutic tools that could be combined with other HBV/WHV antiviral strategies to suppress chronic HBV infection and HBV derived HCC.

Keywords: vaccines,dna therapy,biomedical engineering,hepatitis b virus,chronic viral infection,hepatocellular carcinoma,hepatitis,recombinant virus,hepadnaviridae,orthohepadnavirus,woodchuck hepatitis
Quantum Optomechanics for Fundamental Experiments in Space (QOFES)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Austria
Call:  (FP7-PEOPLE-2010-RG, 2010)
Start date: 2011-03-01
End date: 2014-02-28
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Quantum theory has been confirmed to extreme accuracy in a vast variety of experiments over the last century. While most of these experiments have been limited to a microscopic scale, several milestones in demonstrating quantum effects for more and more massive objects have been achieved, in particular by experiments on the interference of large molecules. In the last few years, a new approach to test quantum physics with significantly more massive objects has emerged where the electromagnetic field is used to achieve control over massive mechanical resonators, eventually into the quantum regime. In particular, quantum optomechanics deals with resonators that are coherently controlled via optical fields. Such systems allow for unprecedented levels of accuracy in the measurement of forces. Eventually, by preparing these massive resonators in non-classical states of motion, they may enable the investigation of quantum effects in a regime where gravitation becomes non-negligible. A limiting factor so far has been the coupling of the resonator to its environment. Using nanospheres levitated in optical trapping potentials, promises to overcome that limitation and will allow for high-precision measurements of gravitation as well as novel experiments on the frontier between quantum theory and the theory of relativity. Space provides an ideal environment for such experiments. Using a spacecraft like the one used in the LISA Pathfinder mission, it is possible to combine a micro-gravity environment, which allows for a much higher mass of the levitated spheres and reduces many sources of noise (e. g. seismic), with readily available optical space technology. This research proposal aims at designing possible experiments with levitated optomechanical resonators in space, testing the feasibility of these schemes in ground-based experiments, and investigating the prerequisites of fundamental optomechanical experiments in space.

Keywords: physical sciences,technological sciences,space experiments,foundations of physics,quantum physics,gravitation
HOlistic Performance System Analysis-EU (HOPSA-EU)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: International Cooperation
Action type: Collaborative project
Countries involved: Germany,Spain,Germany,Sweden
Call:  (FP7-ICT-2011-EU-Russia, 2011)
Start date: 2011-02-01
End date: 2013-01-31
Duration (months): 24.0
Total project cost (EUR): 1925138.0
EU funding (EUR): 1399966.0
Participants: 5
Project status: CLOSED

To maximise the scientific output of a high-performance computing system, different stakeholders pursue different strategies. While individual application developers are trying to shorten the time to solution by optimising their codes, system administrators are tuning the configuration of the overall system to increase its throughput. Yet, the complexity of today's machines with their strong interrelationship between application and system performance presents serious challenges to achieving these goals. The HOPSA project (HOListic Performance System Analysis) therefore sets out to create an integrated diagnostic infrastructure for combined application and system tuning - with the former being under EU and the latter being under Russian responsibility. Starting from system-wide basic performance screening of individual jobs, an automated workflow will route findings on potential bottlenecks either to application developers or system administrators with recommendations on how to identify their root cause using more powerful diagnostic tools. Developers can choose from a variety of mature performance-analysis tools developed by our consortium. Within this project, the tools will be further integrated and enhanced with respect to scalability, depth of analysis, and support for asynchronous tasking, a node-level paradigm playing an increasingly important role in hybrid programs on emerging hierarchical and heterogeneous systems. Using our infrastructure, the scientific output rate of a system will be increased in three ways: First, the enhanced tool suite will lead to better optimisation results, expanding the potential of the codes to which they are applied. Second, integrating the tools into an automated diagnostic workflow will ensure that they are used both (i) more frequently and (ii) more effectively, further multiplying their benefit. Finally, our holistic approach will lead to a more targeted optimisation of the interactions between application and system.

Keywords: performance analysis tools for high-performance computing
Diffeomorphism Invariant Gauge Theories, Asymptotic Safety and Geometry (DIGT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Fundamental constituents of matter
Countries involved: United Kingdom
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-01-01
End date: 2017-06-30
Duration (months): 66.0
Total project cost (EUR): 1222830.0
EU funding (EUR): 1222830.0
Participants: 1
Project status: CLOSED

The aim of the proposed research is to develop a new description of gravity in four spacetime dimensions. This will (i) serve as a new tool to investigate the conjecture that four-dimensional quantum gravity may be ultra-violet complete (asymptotically safe); (ii) provide new techniques for the problem of classification of geometric structures on four-manifolds. To this end we shall study a certain large class of diffeomorphism invariant SU(2) gauge theories. The low-energy physics of these theories is known to be indistinguishable from that of general relativity (GR). At high energies, they provide an interesting type of deformations of GR, with the key property that the number of propagating degrees of freedom is the same as in general relativity. To test the asymptotic safety conjecture we shall perform perturbative one-loop computations to determine how these theories are renormalized by quantum corrections and then study the resulting renormalization group flow. The same class of theories will also be used to solve some of fundamental conjectures about the geometric structures on four-manifolds. The most optimistic scenario results will prove the asymptotic safety in four-dimensional quantum gravity and explicitly describe the physics occurring around the ultra-violet fixed point. The impact of this on theoretical physics will be comparable to the impact of the 1973 discovery of asymptotic freedom on the high energy physics. The work on the proposal will involve some of the world leading scientists as collaborators and advisors. The project will be carried out in the School of Mathematical Sciences at the University of Nottingham, one of the major mathematics research centres in the UK. Regular long-term research visits to our group by leading scientists, as well as three meetings planned will establish the PI Nottingham research group as one of the leading European centres in the subject area.

Keywords: asymptotic safety conjecture in quantum gravity,classification of geometric structures on 4-manifolds
Integrated and Cost-Effective Solution to reduce the volume of Pig Slurry, minimize Pollutant Emissions and Process Energy Consumption (EFFICIENTHEAT)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: France,Spain,Finland,Spain,Switzerland
Call:  (FP7-SME-2011, 2011)
Start date: 2011-10-01
End date: 2013-09-30
Duration (months): 24.0
Total project cost (EUR): 1372637.8
EU funding (EUR): 1084300.0
Participants: 6
Project status: CLOSED

The increase of EU pig production and the intensification of its practice resulted of an increase of pig waste production. In 2008, more than 930 million m3 of pig slurry was produced in the EU. Pigs are raised indoor and the manure collected is mostly slurry. Pig farmers need to treat a great volume of residue with high viscosity and variable physico-chemical composition. The leaks and air emissions associated to pig slurries storage and handling lead to new socio-economic and environmental challenges. In response to these manure handling problems, guidelines and regulations have been introduced in many EU countries. In order to comply with these regulations, farmers are forced to change farming practices by investing in manure storage and disposal facilities and manure treatments which increase the total production costs. In order to increase their competitiveness, pig farmers in Europe must reduce the waste volume and the costs associated with waste treatment and transport. Besides, this sector faces technical limitations of the treatment equipment, many time associated with fouling formation. Treatment technologies are used on larger farms (e.g. separation, composting systems, evaporation, anaerobic treatments and aeration to reduce nitrogen surplus and odours). None of the current technologies is close to an optimal solution and present important technological and economical obstacles that avoid them to be adopted by the SMEs sized pig farmers. There is a need of finding an integrated and efficient solution to reduce the volume of pig slurry, minimize pollutants emission and optimizing energy consumption during the treatment process. The aims of EfficientHeat is to develop an affordable technology for all types of farmers which reduces the transportation cost, currently accountings for almost 60% of the total processing costs. EfficientHeat will also permit an increase of the energy efficiency up to 20% and the abatement of emissions (N-compounds) reducing foul odours. Additionally, EfficientHeat will also provide for nutrient recovery for recycling and reuse.

Keywords: ion exchange,heat exchanger,struvite precipitation,nitrogen,phosporus,slurry management
A new TAXI application guided by SATellite (TAXISAT)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Support to the European global satellite navigation system (Galileo) and EGNOS
Action type: Collaborative project
Countries involved: France,Spain,France,Belgium
Call:  (FP7-GALILEO-2011-GSA-1-b, 2011)
Start date: 2012-01-04
End date: 2014-03-03
Duration (months): 24.0
Total project cost (EUR): 769685.04
EU funding (EUR): 480076.0
Participants: 4
Project status: CLOSED

Automatic and driverless vehicles do operate already, making use of anti-collision devices which enable their perfectly safe movings. But currently, most of these systems are guided by railways, fiberglass or magnetic wires. More recently, a few demonstrations have been undertaken in order to demonstrate the capabilities of satellite based navigation systems to clear the roads from such heavy infrastructures. Particularly, ROBOSOFT and M3SYSTEMS designed several transportation platforms which guidance was based on Differential GPS hybridized with inertial systems. Although such vehicles are operational today, their GNSS based navigation equipment are seen as being very expensive for allowing a larger vehicle deployment. Moreover, the vehicles have to go very slowly when going along buildings as soon as ‘light’ canyoning effects are observed. As a result, pilot users explained they were not confident enough in the reliability of the service they got. In this context, the TAXISAT project aims at developing a driverless GNSS based taxi application capable to operate cost effectively, safely and with a high reliability within private circumscribed sites whatever their topographic configurations are. Indeed, the TAXISAT consortium is convinced that considerable gains could be achieved with the new EGNOS and GALILEO capabilities in order to reach the 1-meter accuracy positioning asked for the sake of transportation safety, while making use of future mass market GNSS systems. The current GPS receiver developed by M3SYSTEMS will be improved through the development of specific EGNOS/EDAS processing filters and the hybridation with SLAM video in masked areas. The use of the “the expected path of the vehicle” will also be used to improve the navigation filter performance. The TAXISAT service will be integrated and tested in real conditions for a few weeks on one or two sites of demonstration. Experimentations with the IOV GALILEO signals will be also conducted.

Keywords: transport system,automatic and driverless vehicle,gnss algorithms hybridized with inertial sensors and odometers,1-meter accuracy positioning
WalkEGNOS: a social web 2.0 mapping solution generating and leveraging on the brand EGNOS Certification Inside (WALKEGNOS)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Support to the European global satellite navigation system (Galileo) and EGNOS
Action type: Collaborative project
Countries involved: Italy,Austria,France,Italy
Call:  (FP7-GALILEO-2011-GSA-1-b, 2011)
Start date: 2012-01-04
End date: 2014-01-03
Duration (months): 24.0
Total project cost (EUR): 368807.5
EU funding (EUR): 296980.0
Participants: 4
Project status: CLOSED

In outdoor applications a critical issue in using GNSS is the availability of trustable maps of routes and path. Three ways were followed to face this issue: 1. Digital maps based on available traditional maps (very inaccurate, not up-to-date); 2. Survey of tracks with geodetic GPS terminals (very expensive); 3. Voluntary upload of tracks by users (not validated, not using EGNOS), like e.g. www.walkGPS.com. WalkEGNOS sets up a solution consisting of: • A web site, www.walkEGNOS.eu, to collect and share routes and tracks acquired by hikers using GPS. • A post processing EGNOS/EDAS-based server to post-process raw GPS data sent by users, measuring the “reliability” of the data provided and evaluating tracks quality. Those data will be the core of: o A section for leisure users with free tracks available; o A section for professional users targeted at private/ institutional users requiring security, higher precision and/ or additional info. • An aggressive marketing approach to foster the diffusion of EGNOS/EDAS concepts while generating revenues, by: o Offering free low-cost receivers to institutions (e.g. rescue services) in exchange of a certain number of “walkings” to reach a critical tracks mass; o Generating an “EGNOS Certification Inside” brand and promoting it via a web community; o Offering internet ads, online receivers sale and value added and/or consulting services to professional users as a way to generate revenues. • A built-in evolution towards Galileo with the sister site www.walkGALILEO.eu. The database containing information on reliable routes will open new opportunities for high quality leisure/ touristic services and will be of great value for search and rescue operations. Organisations entrusted with the maintenance of paths will also profit from this database. At the same time EGNOS will benefit from an awareness campaign making EGNOS and EDAS the centre of a social network including professional and leisure users

Keywords: hiking,egnos,edas,galileo,web 2.0,outdoor,lbs,mountain
Marine Park Enhanced applications baseD on Use of integrated GNSS SErvices (MEDUSE)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Support to the European global satellite navigation system (Galileo) and EGNOS
Action type: Collaborative project
Countries involved: Belgium,Italy,United Kingdom,Italy
Call:  (FP7-GALILEO-2011-GSA-1-b, 2011)
Start date: 2012-02-01
End date: 2013-09-30
Duration (months): 20.0
Total project cost (EUR): 519207.01
EU funding (EUR): 368775.0
Participants: 5
Project status: CLOSED

Marine parks are areas which deserve an extremely accurate care of the ecosystem and as such are usually subject to severe restrictions applied to their end users, first of all leisure boats and local operators. Those restrictions are often different in different areas depending onto the level of threat that anthropogenic activities may exercise on local environment. As an example, in some areas boat transit may be fully prohibited, in others fishing and anchorage, in others night anchorage, etc. In order to limit and control the access to restricted areas, very often parks management organisations force users to request for a permit (e.g. daily or weekly, free of charge or not) without which the boats are not allowed to enter the marine park. In compliance with the different ways for accessing the park, also permits are different (e.g. transit and anchorage, shore fishing, sea fishing, scuba diving…). The main objectives of the Meduse Project can be summarised as follows: a) To develop a prototype service infrastructure for the delivery of location based services within restricted access maritime areas (parks, reserves) to the following customer categories: i. Institutional – Marine parks and restricted marine areas management institutions; ii. Private - Marine parks and restricted marine areas users (leisure boats); iii. Commercial – Commercial operators acting within restricted areas (e.g. cruise boats); iv. Law Enforcement – Maritime police authorities (Coast Guard). b) To demonstrate a subset of services and applications (with limited functionality) that shall be enabled by the service infrastructure for all the above listed customer categories; c) To analyse commercial sustainability of the service infrastructure in order to identify and characterise the critical mass of applications and services that shall bring sustainability and define associated service models towards the different customer categories.

Keywords: marine protected park,lbs,maritime,environmental monitoring
EGNOS and EDAS Enhanced Tracking of Animal Movement and Behaviour (E-TRACK)

Framework: FP7 — Cooperation
Programme: Transport (including Aeronautics)
Destination: Support to the European global satellite navigation system (Galileo) and EGNOS
Action type: Collaborative project
Countries involved: Netherlands,Netherlands,Germany,Netherlands,United Kingdom
Call:  (FP7-GALILEO-2011-GSA-1-b, 2011)
Start date: 2012-01-01
End date: 2013-12-31
Duration (months): 24.0
Total project cost (EUR): 727948.05
EU funding (EUR): 473991.0
Participants: 6
Project status: CLOSED

For many years, scientists and wildlife managers have used radio tracking and satellite tracking to follow the location of freely moving animals in the wild. However, existing technology suffers from limited temporal and spatial resolution: positioning data are too coarse to determine how animals behave relative to their environment and each other. In other words: one can measure where an animal approximately is, but not what it is doing. Current GNSS-based tracking systems are not able to track moving objects at short time intervals. Furthermore, software tools capable of processing large volumes of GNSS data and converting those into meaningful metrics describing animal behaviour are missing. The E-TRACK project concerns the development of a system for measurement and analysis of movement, behaviour and interactions of wildlife. The system will consist of EGNOS-enabled GNSS receivers, efficient data communication and an innovative software application. E-TRACK will take advantage of EGNOS and EDAS to provide adequate resolution for behaviour analysis. In addition, EGNOS and EDAS data will be used in post-processing to analyse the data points. In order to execute the project, a consortium has been formed of six partners, including three SME companies: a software company (Noldus Information Technology) with many years experience in measurement and analysis of animal behaviour; a manufacturer of wildlife telemetry hardware (Biotrack); a consulting firm in the domain of remote sensing and geo-informatics (AeroVision); a university group with expertise in behaviour and ecology of large mammals (Resource Ecology Group, Wageningen University); and two research institutes with expertise in behavioural ecology of birds (NIOO and IZW). The project will develop a fully working end-to-end system that will be tested, validated and demonstrated by the scientific partners. The project will also develop a business plan how to launch the system in the market.

Keywords: gnss,gps,egnos,edas,animal behaviour,movement tracking,behaviour recognition,widlife management