Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Papyri and LAtin Texts: INsights and Updated Methodologies. Towards a philological, literary, and historical approach to Latin papyri (PLATINUM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Italy
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2022-07-31
Duration (months): 88.0
Total project cost (EUR): 1485712.0
EU funding (EUR): 1485712.0
Participants: 1
Project status: CLOSED

The aim of PLATINUM is to scrutinize Latin texts on papyrus from several points of view in order to highlight their substantial contribution to our knowledge of innovations in ancient Roman literature, language, history, and society, especially in the multilingual and multicultural contexts of the Eastern part of the Empire between the 1st century B.C. and 8th century A.D. The first phase of the project will consist in assembling, updating and publishing critical editions, in order to present a new and more accurate corpus of Latin papyri on an easily accessible online platform. The second phase will be focused on providing the texts with a specific, pluridisciplinary commentary that gives new insights on Roman culture. Coming mainly from Egypt and other Roman provinces (as well as Herculaneum and Ravenna), Latin papyri deserve more scholarly attention not only from papyrologists and paleographers, but also from scholars of Latin language, as well as intellectual and cultural historians of Rome. Latin papyri, tablets, and ostraka (potsherds) are constantly increasing in number through archaeological discoveries. Because they are so rare, they are even more valuable than the Greek papyri, which have garnered much attention. The Latin papyri have hitherto represented a border-line field of study that has not been fully exploited either by papyrologists or by scholars of Latin literature. Moreover, the obsolete bibliography and the considerable number of unpublished texts make the study of Latin papyri (and bilingual Latin-Greek, Latin-Coptic, Latin-Punic texts) - whether literary (e.g. Cicero, Vergil, law), paraliterary (grammar, medicine, magic), or documentary (letters, official registers, receipts) – a pioneering and challenging task. A more through study will reveal the untapped potential of Latin texts on papyrus for renewing our knowledge of the circulation and reception of Latin language and education, as a cultural engine in Mediterranean societies.

Keywords: latin philology and literature,papyrology,manuscript tradition and transmission,education in antiquity,latin greek bilingualism,cultural history of the roman empire,latin documentary sources
Float zone silicon from electron beam grown rods (EBFZ)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Latvia
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-10-01
End date: 2017-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

For the first time a technology for skull (cold crucible) growth of high purity silicon rods of high diameter, which can be used for float zone (FZ) single crystal growth, is developped. This technology enhances economical efficiency of FZ method compared to abandunt use of FZ rods obtained in Siemens process and for the first time enables FZ secondary silicon recycling inside FZ process. As a result, affordability of FZ single crystals enables their use in photovoltaics and for power rectifiers for either volatges over 2,5kV or in 1-2,5kV range where nowadays other types of silicon are used due to their lower price. Employment of this technology shall increase PV modules efficiency and return high efficiency PV production back to Europe from China creating new jobs. Developped technology can also be applied to other high purity materials, e.g. refactory metals. During Phase 1 we plan to update market information by manufacturing sample single crystalline wafers from our material and supply them to potential customers. Also we plan to analyze market by ourselves and buy an expert market review on our market segment, disseminate knowledge about our technology at SEMICON Europa conference. Based on our negotiations with potential customers we plan to find out their requirements for FZ wafers, make such wafers from our material by cooperation and transfer wafers to customers for quality testing and price negotiations. That information shall enable us to prepare a detailed business plan for Phase 2 project realization. During Phase 2 we plan to acquisite FZ furnace for single crystal growth and create up to 60 jobs in vertically integrated FZ production which will have stable cheap feedstock supply thanks to our EB rod growth technology and customer ready product (FZ crystals) with wide client base.

Keywords: advanced technology,silicon,poewr microelectronics,photovoltaic,electron beam,float zone
A Peer learning based pilot scheme for using the H2020 Seal of Excellence at national level (SME-SEALING)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Ireland,Spain,Finland
Call: Peer learning of innovation agencies (H2020-INNOSUP-05-2016-2017, 2016)
Start date: 2016-11-01
End date: 2017-03-31
Duration (months): 5.0
Total project cost (EUR): 50000.0
EU funding (EUR): 50000.0
Participants: 3
Project status: CLOSED

The Seal of Excellence (SoE) is a new initiative launched at European level in October 2015 that aims to foster synergies between H2020 and other funding resources, mainly at regional and national level. The idea behind this SoE is to offer a gateway to companies and organizations across Europe that apply to the Horizon 2020 Programme and despite of meeting all the stringent thresholds of the calls, they can not be funded due to the lack of available budget. The first instrument where the Seal of Excellence has been implanted is the H2020 SME instrument. In that context, this Seal of Excellence linked to the SME instrument proposers offers a clear added value to national and regional authorities as a reliable filter of promising companies with international ambition, meriting an European funding but unable to achieve it, but still worth to be supported. For the phase 1, during 2015, a number of countries and regions have already been able to launch at national or regional level support mechanism for the Seal of Excellence phase 1 holders, mainly channelled through the “de minimis” regime. For the phase 2, the paths are not so direct considering Technology Readiness Level of 6 as starting point. This is the rationale of this proposal: to use the peer learning advanced methodology, proposed by the topic, together with the current tools from the lean start-up methodologies to develop and test different approaches to the valorisation of the Seal of Excellence for the SME instrument phase 2 within a small consortium of national innovation agencies (CDTI (ES), Enterprise Ireland (IE) and TEKES (FI) with a long tradition of collaboration among them, a strong know-how on the SME instrument and in charge of national programmes in support of SMEs through grants, loans and/or equity.

Keywords: seal of excellence,sme instrument,twinning advance
Generating a targeted, brain-permeable and stable polymeric nanoparticle for systemic gene delivery to glioblastoma (TargetGBM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 160932.48
EU funding (EUR): 160932.48
Participants: 1
Project status: CLOSED

Glioblastoma multiforme (GBM) is the most prevalent deadly brain tumour and is currently incurable. Patients die from recurrent tumours that grow from cells surviving the first round of treatment. This is mainly due to the narrow therapeutic window of current drugs and to the low permeability of these drugs across the blood-brain barrier (BBB). Targeted non-viral delivery systems have shown great promise to decrease side effects of therapeutics and to enable the transport across biological barriers. The main objective in this proposal is to generate a dually targeted nanoparticle loaded with mRNA encoding a conditionally toxic protein to treat brain cancer. The nanoparticle will be modified with two ligands: an antibody for targeting tumour cells and a peptide that enables transport across the BBB. In addition, I will develop an acid-labile coating that enhances the stability of the polyplex in blood and is released upon internalization. This coating will present the ligands in a defined orientation using bioorthogonal chemistry, thereby maximising their targeting efficiency. The chemical handles will be introduced using genetic code expansion in the antibody and solid-phase synthesis in the peptide. A variety of formulations will be screened in vitro to evaluate their stability and transfection efficiency, and BBB permeability will be assessed in a human cell-based BBB model. Subsequently, the efficacy of the most promising candidates will be tested in a GBM mouse model. The combination of a polyplex having high transfection efficiency with a sheddable coating and oriented targeting ligands is designed to generate the first efficient non-viral gene delivery system for the systemic treatment of GBM, reaching all tumour cells to provide a more efficient treatment and potentially prevent recurrence.

Keywords: blood brain barrier,glioblastoma,gene delivery,polymeric nanoparticles,bioorthogonal chemistry,peptide chemistry,site specific protein modification
SPin Research IN Graphene (SPRING)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Switzerland,Netherlands,United Kingdom
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2019-10-01
End date: 2024-03-31
Duration (months): 54.0
Total project cost (EUR): 3486536.25
EU funding (EUR): 3486536.25
Participants: 6
Project status: SIGNED

Future Information Technology will take advantage of quantum materials for efficient information processing and communication. In SPRING, we propose to utilize custom-crafted graphene nanostructures as elementary active components of a new generation of nanoscale quantum spintronic devices. Graphene structures can spontaneously develop intrinsic π-paramagnetism from topological frustrations of their structure. This unconventional magnetism is mobile, long-ranged and can be electrically addressable. The targeted long-term vision is the development of an all-graphene platform, where spins can be used for transporting, storing and processing information. This new technology paradigm will combine fast electron mobility with electrically addressable quantum spins, in a customizable semiconducting platform, envisioning clear impact on scientific, technological and societal stakeholders. To advance towards this goal, the interdisciplinary project SPRING combines research in physics, chemistry and engineering to fabricate graphene nanostructures with atomic precision, demonstrate and manipulate their electron and nuclear spin states, and test their potential as basic element in quantum spintronic devices. On-surface synthesis strategies will be utilized to create atomically precise open-shell graphene nanostructures with radical character, including frustrated magnetic states, spin-polarized bands, spin chains, and nuclear spins embedded at specific sites. We will demonstrate the emergence of π-magnetization and unveil the time and energy scales of spins in the open-shell structures through a combination of scanning probe and electron spin resonance spectroscopies, and develop novel predictive models of their quantum functionality. The potential of graphene open-shell platforms as a novel paradigm in spin-based logic devices will be tested by incorporating them into model devices and electrically addressing and manipulating spins.

Keywords: graphene nanostructures,graphene nanoribbons,on surface synthesis,electron transport,quantum physics,nanoscale devices,nuclear spin,quantum spintronic devices
Innovative biomaterials production from wine industry waste (VegeaTextile)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-2-2016-2017, 2017)
Start date: 2018-03-01
End date: 2019-12-31
Duration (months): 22.0
Total project cost (EUR): 801875.0
EU funding (EUR): 561312.0
Participants: 1
Project status: CLOSED

Vegea is a young start-up with a solid chemical background with long experience in natural polymers and industrial processes, constituted by researchers coming from the academy with a strong entrepreneurial inclination. It has already received several awards recognizing the value of its disruptive innovation, such as Start&Cup Award-2015, Start&Re-Start-2016, and H&M Global Change Award-2016 for a total funding of more than €300.000. The main scope of VegeaTextile project is the deployment of an absolute breakthrough innovation demonstrating a novel, cost-effective and eco-friendly process for the production of organic textile and introducing in the European leather goods market a new kind of bio-textile using a non-animal and renewable raw material, considered up today an agricultural waste: the grape marc. In fact, the production process can be classified “low impact” for the environment since it makes minimal use of chemical reagents or additional water, and at the contrary, it produces reusable water from the grape marc exsiccation (60% w/w). Our innovation will allow leather goods manufacturers to answer to the increasing customers’ awareness about environmentalist and animalist concerns, to propose a new product with same quality of common leather and, at the same time, to find an alternative and renewable raw material, helping them to overcome stringent regulations about animal treats and tanning processes. Upon project length we aim at industrializing the process production by 2022, reaching a forecasted production capability of 4.5 million m2/yr, the ambitious business objectives of € 8,64 million net profits over 4 yrs of commercialization (2022), and consequently a greater-than-market ROI (26%) and profitability (22%). For the launch of VegeaTextile by 2019, we foresee a total investment of more than €900.000, of which €801.875 budgeted for the Phase-2.

Keywords: bio based products,agricultural waste recovery,green leather,circular economy
Robotic Assistant for MCI patients at home (RAMCIP)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Spain,Poland,Greece,Greece,United Kingdom
Call: Advancing active and healthy ageing with ICT: service robotics within assisted living environments (H2020-PHC-2014-single-stage, 2014)
Start date: 2015-01-01
End date: 2018-06-30
Duration (months): 42.0
Total project cost (EUR): 3981178.0
EU funding (EUR): 3981178.0
Participants: 8
Project status: CLOSED

RAMCIP will research and develop a novel domestic service robot, with the aim to proactively and discreetly assist older persons, MCI and AD patients in their every day life. Instead of simply being an obedient servant, the RAMCIP robot will have high-level cognitive functions, driven through advanced human activity and home environment modelling and monitoring, enabling it to optimally decide when and how to assist. The robot will provide subtle physical and cognitive user skills training, by maintaining an optimal balance between physical assistance provision and user stimulation to act. The cognitive functions will orchestrate an ensemble of advanced lower-level mechanisms, enabling the robot to (a) communicate with the user and (b) establish dextrous and safe robotic manipulations. Communication will be based on multimodal interfaces, adapted and fused so as to meet the current user’s needs and interaction context. Apart from touch-screen, speech and gestural modalities, RAMCIP will incorporate an augmented reality display, as well as an underlying empathic communication channel, allowing it to sense user affect and moderate it. In the context of robotic manipulations, RAMCIP will introduce advanced dexterity in service robots for assisted living environments; the robot will employ a sophisticated anthropomorphic hand, manipulated though novel grasping and dexterity algorithms, being capable to grasp and manipulate a variety of objects in realistic user homes, supporting also safe handover. Safety will be a major research focus. By establishing safe and dextrous manipulations, emphasis will be paid on physical HRI, enabling novel assistance scenarios that will involve physical contact between the user and the robot. Through multi-faceted proactive assistance enabled through all the above, RAMCIP will advance user independency and quality of life of its user. The robot will be evaluated in two pilot sites that will be deployed in two countries.

Keywords: mild cognitive impairments mci,alzheimer s disease ad,dementia,proactive and discreet assistance,robot cognitive functions,dextrous robotic manipulations,physical hri,safety
Mechanobiology of nuclear import of transcription factors modeled within a bioengineered stem cell niche. (NICHOID)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Italy
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-05-01
End date: 2020-07-31
Duration (months): 63.0
Total project cost (EUR): 1903330.0
EU funding (EUR): 1802830.0
Participants: 2
Project status: CLOSED

Many therapeutic applications of stem cells require accurate control of their differentiation. To this purpose there is a major ongoing effort in the development of advanced culture substrates to be used as “synthetic niches” for the cells, mimicking the native ones. The goal of this project is to use a synthetic niche cell culture model to test my revolutionary hypothesis that in stem cell differentiation, nuclear import of gene-regulating transcription factors is controlled by the stretch of the nuclear pore complexes. If verified, this idea could lead to a breakthrough in biomimetic approaches to engineering stem cell differentiation. I investigate this question specifically in mesenchymal stem cells (MSC), because they are adherent and highly mechano-sensitive to architectural cues of the microenvironment. To verify my hypothesis I will use a combined experimental-computational model of mechanotransduction. I will a) scale-up an existing three-dimensional synthetic niche culture substrate, fabricated by two-photon laser polymerization, b) characterize the effect of tridimensionality on the differentiation fate of MSC cultured in the niches, c) develop a multiphysics/multiscale computational model of nuclear import of transcription factors within differentially-spread cultured cells, and d) integrate the numerical predictions with experimentally-measured import of fluorescently-labelled transcription factors. This project requires the synergic combination of several advanced bioengineering technologies, including micro/nano fabrication and biomimetics. The use of two-photon laser polymerization for controlling the geometry of the synthetic cell niches is very innovative and will highly impact the fields of bioengineering and biomaterial technology. A successful outcome will lead to a deeper understanding of bioengineering methods to direct stem cell fate and have therefore a significant impact in tissue repair technologies and regenerative medicine.

Keywords: mechanobiology,multiphysics,multiscale,mesenchymal,stem cell,differentiation,microfabrication,two photon polymerization,synthetic niche,substrate,cell culture
Feasibility study of internationalisation of dust control products using innovative cleantech technology (DS Products study)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Finland
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-07-01
End date: 2015-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

JMV Urakointi Ltd (JMV), specialising in deconstruction and renovation jobs, has been developing novel dust control products to improve deconstruction and renovation process. According to preliminary studies by patent office, there are no similar products and methods on the EU market. The aim is to be the first company on the EU market providing reusable and affordable dust protection solution, which meet the legislative requirements also in the future. For the purpose of internationalisation of the dust control products, the principal owner of JMV and three other key persons established Dust Shelter Finland Ltd (DSF) in August 2013. The existing dust protection markets in the EU are estimated at 4% of the renovation, i.e. approx. EUR 24 billion per year, which can be expected to increase as the regulations tighten. DSF's turnover target for 2020 is EUR 120 million, representing approx.1% of the European market for dust protection. Today, the dust protection methods used at the construction sites are designed for a single use and they are built at the location. This takes a lot of time and materials, and when dust protections are dismantled after use, they generate waste. In addition, they will not meet tightening requirements in the future. The competitive advantages of the novel dust control products are, among other things that they meet the EU legislation and are reusable offering energy and material efficiency both to construction and deconstruction. In addition, they are easy to dismantle and reinstall, hence the construction work will also proceed faster. Using past customer feedback JMV has identified the key problems in the current dust protection process. The objective of this feasibility study is to systematically survey, by means of the market studies and customer pilots, the needs and the willingness of the potential customers (equipment rental or construction companies) to deploy dust control products and to demonstrate the advantages of products.

Keywords: dust shelter products,doors,walls,frames,compartementation,dust protection,dust control system,deconstruction,renovation,construction,occupational health,resource efficiency