Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative FRET-based toolkit for screening of drugs to fight miRNA-related diseases and its use in the development of cancer treatment with miRNA-96 as a therapeutic target (DrugSearchTool)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-09-01
End date: 2020-08-31
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

The overall goal of this project is to develop a universal FRET-based toolkit for screening of drugs targeting microRNA (miRNA). Specific outcome will be a high-throughput assay for finding drugs targeting miRNA-96, a tumor-suppressing miRNA in pancreatic cancer cells. FRET is the technique of choice and recently, Prof. Marcus Wilhelmsson, Chalmers University of Technology (CHALMERS; project main supervisor) pioneered the development and photophysical characterization of fluorescent base analogues (FBAs) optimized for high-resolution FRET analysis of nucleic acid systems. There is an urgent need in pharmaceutical industry for an in vitro, cell-free, pre-miRNA-small molecule interaction high-throughput assay and also to increase the understanding of the nature of miRNAs. In this project, the unique FRET FBAs will be utilized to develop such assays and to provide new knowledge regarding miRNA structure, dynamics and interactions with other biological molecules or drugs. Apart from taking on the new research field stated above and developing my professional skills, I will bring in new competences to CHALMERS in RNA biochemistry (from the University of Warsaw and Max Planck Institute in Göttingen). Moreover, as part of my training, I will carry out research at AstraZeneca (AZ) and Gothenburg University (UGOT) through secondments. CHALMERS/AZ/UGOT have an established collaboration and I will take full advantage of their R&T capacities in order to gain interdisciplinary and intersectoral expertise as well as to master my skills in scientific communication, scientific writing, coordinating research projects, results exploitation, critical assessment, mentoring, supervision, presentation and networking with other researchers across the globe. This MSCA Postdoctoral Fellowship will help me reaching a position of professional maturity invaluable for starting up my own research group or taking leading roles in industrial R&D organizations.

Keywords: fluorescent nucleobase analogues,fret,mirna,drug assay,pancreatic cancer mirna 96,nucleic acid
Reconstructing community dynamics and ecosystem functioning after glacial retreat (IceCommunities)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Italy,France
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-04-01
End date: 2024-01-31
Duration (months): 70.0
Total project cost (EUR): 1845773.0
EU funding (EUR): 1720738.0
Participants: 2
Project status: SIGNED

Glaciers show a pattern of retreat at the global scale. Increasing areas are exposed and colonized by multiple organisms, but lack of global studies hampers a complete understanding of the future of recently deglaciated terrains. What will be the fate of these areas? How do animals, plants and microorganisms colonize them? How do they interact to perform successful colonization? Which are the climatic, geological and biogeographical processes determining colonization patterns? How does ecosystem functioning evolves through time? Until now, the complete reconstruction of soil communities was hampered by the complexity of identification of organisms, thus analyses at broad geographical and taxonomic scale have been so far impossible. IceCommunities will combine innovative methods and a global approach to boost our understanding of the evolution of ecosystems in recently deglaciated areas. I will investigate chronosequences ranging from recently deglaciated terrains to late successional stages of soil pedogenesis. Through environmental DNA metabarcoding I will identify species from multiple taxonomic groups (bacteria, fungi, protists, soil invertebrates, plants), to obtain a complete reconstruction of biotic communities along glacier forelands over multiple mountain areas across the globe. This will allow measuring the rate of colonization at an unprecedented detail. Information on assemblages will be combined with analyses of soil, landscape and climate to identify the drivers of community changes. I will also identify the impact of eco-geographical factors (climate, regional pool of potential colonizers) on colonization. Analysis of functional traits will allow reconstructing how functional diversity emerges during community formation, and how it scales to the functioning of food webs. IceCommunities will help to predict the future development of these increasingly important ecosystems, providing a supported rationale for the appropriate management of these areas

Keywords: environmental dna,dna metabarcoding,global change biology,functional traits
Single-cell map of the composition and evolution of T-cell acute lymphoblastic leukemia (scTALLmap)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-04-01
End date: 2021-03-31
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

Spaniards have their daily siesta, Germans like sausages and Belgians love beer. Stereotypes can certainly be misleading, just like judging a cell by its membership to a particular cell type, the so-called population-based analysis. Nowadays we know that tumors are tremendously heterogeneous and, in the era of single-cell sequencing, we have the exquisite opportunity to study each individual cell with unprecedented resolution. Acute lymphoblastic leukemia (ALL), which is the most common cancer in children, shows extensive genetic intratumoral heterogeneity. This heterogeneity might be the underlying reason for an incomplete response to treatment and for the development of relapse. In order to envision its clinical implementation, it is essential to first i) generate a single-cell map and ii) accumulate evidence on how the subclonal composition affects the response to treatment. With this aim, I will build a comprehensive single-cell overview of the composition, development and response to therapy for the aggressive subtype T-cell ALL. I will perform integrative single-cell genome and transcriptome profiling of ex vivo carefully selected pediatric samples at diagnosis, during drug treatment and in case of relapse. This approach will provide realtime temporal information about the sensitivity of each cell type to the therapy and about how relapse can develop. I will use state-of-the-art single-cell technologies to which the host institute has early access. Moreover, I will apply my previous single-cell expertise and bring a unique mix of experimental and computational skills to the lab. The results of scTALLmap, will have significant impact in leukemia by paving the way for improved risk-stratification based on the cellular heterogeneity and the presence of high-risk subclones at diagnosis. Ultimately, it will permit the design of novel and more personalized therapeutic modalities sparing toxicity and targeting the full complement of leukemia subclones.

Keywords: t all,leukemia,single cell sequencing,integrative bioinformatics
Mechanisms of TET2 DNA demethylase recruitment to specific genomic regions (TET2rec)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-03-01
End date: 2020-02-29
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

TET2 (Tet Methylcytosine Dioxygenase 2) is a DNA demethylase frequently mutated in patients with Acute Myeloid Leukemia (AML). DNA methylation is an epigenetic modification with key roles in the specification of cellular identity, and, when deregulated, in cancer. DNA methylation is a reversible process and, only recently, it was discovered that TET (Ten-eleven Translocation) proteins mediate DNA demethylation. Mammals have three TET homologues (TET1-3). While TET1 and TET3 share an N-terminal DNA-binding domain (CXXC motif), TET2 has lost its CXXC motif during evolution. Therefore, it is not understood how TET2 binds DNA. Due to the lack of a known DNA-binding domain in TET2, I hypothesize that TET2 may require to interact with proteins to be recruited to DNA, which is essential for its function. Hence, the main goal of my proposal is to understand how TET2 binds to DNA and to identify interacting proteins that participate in this recruitment. I also aim to unveil whether cancer-associated mutations affect TET2 recruitment. To achieve these goals, I will perform a structural-functional analysis of TET2. First, I will perform Chromatin Immunoprecipitation (ChIP) followed by whole genome sequencing of wildtype and truncated TET2. Thus, I will identify the region(s) required for the binding of TET2 to DNA. Next, I will seek proteins that interact with TET2 through the previously identified region by Mass Spectrometry and I will test their involvement in TET2 recruitment to DNA. Furthermore, I will perform similar experiments to inspect the impact of TET2 missense mutations found in human cancer on TET2 recruitment to DNA. Altogether, this project will yield a better understanding of how TET2 is recruited to DNA. The results obtained will significantly impact the epigenetic field and allow for a better understanding of the mechanisms by which TET2 exerts its function in normal cells and how TET2 mutations contribute to cancer.

Keywords: tet2,dna binding,dna methylation,chromatin immunoprecipitation chip,mass spectrometry,es cells
PrOcess intensification and innovation in olefin ProducTIon by Multiscale Analysis and design (OPTIMA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Belgium
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-09-01
End date: 2025-02-28
Duration (months): 66.0
Total project cost (EUR): 1995000.0
EU funding (EUR): 1995000.0
Participants: 1
Project status: SIGNED

New manufacturing techniques such as 3D printing have the potential to drastically transform the chemical industry. Novel, complex, integrated reactor designs can now be created, that will allow to unlock alternative chemical routes, such as for methane activation. Driven by process intensification and the power of high performance computing, this project will enhance heat and mass transfer in advanced chemical reactors by multiscale modelling and experimentation. OPTIMA aims to: (1) develop in silico novel 3D reactor technologies and concepts with significantly improved selectivity and heat transfer by the use of additive manufacturing; (2) generate new fundamental understanding of kinetics, heat transfer and mass transfer by using advanced measuring techniques for processes of both current and future importance; (3) demonstrate the practical applicability of an open-source multiscale large eddy simulation (LES) platform in combination with finite rate chemistry for turbulent reacting flows; (4) transform the chemical industry by valorising methane and converting it to a platform molecule through oxidative coupling of methane. OPTIMA will focus on two olefin production processes of industrial and social importance in Europe, the exothermal oxidative coupling of methane and the endothermic steam cracking, demonstrating the universality of the proposed new paradigm. Starting from fundamental experiments and kinetic modelling (WP1), detailed chemistry will be implemented in an open-source LES multiscale modelling framework (WP2) generating in silico novel 3D reactor technologies with significantly improved selectivity (WP3). The power of the approach will be ultimately demonstrated in a novel, 3D integrated reactor, in which the studied exothermic and endothermic processes are cleverly combined (WP4). OPTIMA will pave the way for designing the 3D reactors of tomorrow and promote the new techniques and tools that will be driving innovation in the next decades.

Keywords: oxidative coupling of methane revolution,rotor reactor,turbulator reactor,olefin production
Direct and transgenerational consequences of divergent reproductive strategies on ageing trajectories of parents and their offspring (REPRODAGEING)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2022-09-30
Duration (months): 36.0
Total project cost (EUR): 319400.64
EU funding (EUR): 319400.64
Participants: 1
Project status: CLOSED

Understanding why we age and die, and why individuals differ in their ageing trajectories remains one of the big challenges for science. REPRODAGEING uses a combination of complementary approaches and cutting-edge techniques from evolutionary biology, behavioural ecology and ecophysiology and an innovative avian life history model – Japanese quail (Coturnix japonica) artificial selection lines that differ genetically in their pace of life – to quantify how divergent reproductive strategies influence individual, sex-specific and transgenerational ageing trajectories. I will use biomarkers of oxidative stress and ageing to quantify within-individual mosaics of physiological damage accumulation across somatic and reproductive tissues and test if these within-body mosaics of ageing are shaped by an individual’s life history strategy. Furthermore, I will quantify how parental physiological states at conception affect the next generation and if these transgenerational effects are shaped by the quality of the early life environment. I will be hosted at the Centre for Ecology & Conservation, University of Exeter, UK, which is one of the leading departments for evolutionary whole-organism research in Europe. The host complements my own research strengths in an ideal way, ensuring a successful implementation of the project, and allowing me to develop my research profile. At the same time, I will enhance the host’s expertise and capacity in ecophysiological research. Thus, this fellowship will enhance my skills and career prospects through a two-way transfer of knowledge. REPRODAGEING is highly relevant for fundamental evolutionary biology, but has also implications for biomedicine, assisted reproduction, animal breeding and wildlife conservation, and it will contribute to enhance the European science excellence and competitiveness.

Keywords: life history evolution,costs of reproduction,evolution of ageing,oxidative stress,transgenerational effects
Markets and their limits (MARKLIM)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance and management
Countries involved: France
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2016-04-01
End date: 2022-09-30
Duration (months): 78.0
Total project cost (EUR): 2096500.0
EU funding (EUR): 2096500.0
Participants: 2
Project status: CLOSED

This project aims at investigating new frontiers in the regulation of individuals, firms and the state. It will build on traditional tools, game theory, information economics and mechanism design, further these tools and apply them to a wide range of important economic issues. It will be organized around five topics: - Morality and markets. The goal is to organize the disparate evidence from economics and psychology on how moral behavior is generated, to provide a coherent framework on how to think about moral issues to study their implications for organizations and to run experiments on the matter. - Intellectual property and public policy with the writing of a monograph and an empirical analysis of the standards-patent pool interface. - Industrial organization, and more specifically two-sided markets and merger policy. The research will apply two-sided market economics to shed light on the “must-join platform” argument and on potential regulations of the intermediation activity. - Debt crises including various and yet little studied aspects of banking and sovereign debt crises. - Investigate the political economy of regulation, and much more generally political science. Finally, the project will emphasize methodological aspects. It will extend the concept of Markov Perfect Equilibrium to games of imperfect information. On the mechanism design front, it will pursue a new line of research on “positive selection”. This methodological project will branch into a more applied project. It will consider an organization or a country run by a ruler/dominant group that is hostile toward a minority on religious, ethnic, linguistic, cultural, wealth or sexual-orientation grounds. It will investigate the dynamics of compositional change in such environments. Also, the project will complete and extend research on cognitive games, defined as games in which a normal- or extensive-form game is preceded by players’ selecting their or their rivals’ information structures.

Keywords: information,markets,incentives,morality,standardization
COOPERATION OF RESEARCH INFRASTRUCTURES TO ADDRESS GLOBAL CHALLENGES IN THE ENVIRONMENT FIELD (COOP_PLUS)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Coordination and support actions
Countries involved: Germany,Spain,Italy,Ireland,Italy,Spain,Finland,Sweden,France
Call: International cooperation for research infrastructures (H2020-INFRASUPP-2014-2, 2014)
Start date: 2016-03-01
End date: 2018-12-31
Duration (months): 34.0
Total project cost (EUR): 1997990.0
EU funding (EUR): 1997990.0
Participants: 10
Project status: CLOSED

The COOP+ project is motivated by the interest of several Research Infrastructures in Europe to benefit from extending international collaboration with other Research Infrastructures in their areas of expertise at global, worldwide level.The general goal of COOP+ is to strengthen the links and coordination of the ESFRI Research Infrastructures related to marine science, Arctic research and biodiversity with international counterparts and to leverage international scientfic cooperation and data exchange with non-EU countries aiming at creating a common ground for the development of a global network of research infrastructures that are able to address Global environmental challenges. The project will be the central hub for worldwide collaboration of the RIs involved, coordinating all their common activities and fostering international agreements. As the EC communication emphasized, Global Challenges are very important drivers for research and innovation, and COOP+ will focus on them, and, according to the experience in COOPEUS (FP7), will try to reinforce the cross-disciplinary view, adding participants for other regions. COOP+ will use the methodology of case studies to assess the cooperation capabilities of international RIs, and to learn how to cope with global environmental challenges.This cross-disciplinary and global collaboration among Research Infrastructures tha is required to address these challenges implies a significant effort on common practices including access and sharing of data. COOP+ will promote an open coordination framework for Global Cooperation, with initial participation from relevant RI from EU, US, Canada, Australia and Brazil, and providing support to new agreements on reciprocal use or access to RI, openness, joint development of new resources including co-financing.

Keywords: cooperation,synergies,biodiversity,artic,marine,research infrastructure,global challenges
The European Research Infrastructure for Heritage Science Preparatory Phase (E-RIHS PP)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Coordination and support actions
Countries involved: Italy,Germany,Spain,Spain,Ireland,Italy,Italy,Italy,Israel,Cyprus,Hungary,Poland,Hungary,Belgium,Greece,Greece,Slovenia,France,France,Czechia,Netherlands,United Kingdom,Portugal,Portugal
Call: Preparatory Phase and support to early phase of ESFRI projects (H2020-INFRADEV-2016-2, 2016)
Start date: 2017-02-01
End date: 2020-09-30
Duration (months): 44.0
Total project cost (EUR): 3999449.0
EU funding (EUR): 3999449.0
Participants: 29
Project status: CLOSED

E-RIHS PP is a coordination and support action addressing the topic “Preparatory Phase and support to early phase of ESFRI projects” within the call H2020-INFRADEV-02-2016. The specific action addressed by this project is the preparation of E-RIHS, the European Research Infrastructure for Heritage Science (HS), one of the six new projects which entered the ESFRI Roadmap in 2016, and the only research infrastructure project in the Social and Cultural Innovation section of the Roadmap. E-RIHS will help the preservation of the World’s Heritage by enabling cutting-edge research in HS, liaising with governments and heritage institutions to promote its constant development and, finally, raising the appreciation of the large public for cultural and natural heritage and the recognition of its historic, social and economic significance. E-RIHS PP will start in 2017 and will last three years (2017-2020). The first two will be used to address governance, financial aspects, legal documents and logistics. This will lead to a business plan ready for application to ERIC, or to another suitable legal form, by 2019. The last year will be devoted to negotiations with stakeholders, based on the agreed instruments, further strategic planning and to start up of activities for entering the transition phase. E-RIHS will hopefully be launched as a stand-alone RI in 2021.

Keywords: research infrastructure,heritage science