Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Silica and alumina nanophases – the building blocks for the ground under our feet. (NanoSiAl)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-05-01
End date: 2019-10-30
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Alumina and silica nanophases play a crucial role in rock weathering and their formation and destruction controls Earth’s response to global climate change. The presence of various products of aqueous weathering of aluminosilicates points to a complex activity of water, and is considered as the geological indication for the occurrence of life-habitable conditions. In this regard, a more complete picture of the water-alumina-silica interactions would allow for better specifying the molecular-level conditions for early life. Upon weathering the original Al- and Si-containing phases are dissolved at the solid-water interface, undergo hydrolysis and condensation reactions and form new colloidal nanoparticles. However, quantitative and mechanistic understanding of the underlying processes that lead to the formation and types of Al and Si phases is still lacking, due to the insufficient in situ methodology providing structural information about the colloidal species in solution. Therefore, the main objective of the NanoSiAl project is to develop, test and validate the methods for the direct in situ and real-time structural and kinetic characterisation of the alumina and silica colloid formation pathways at the length-scale of < 100 nm. I will achieve this by utilising state-of-the-art in situ liquid-cell transmission electron microscopy (L-C TEM) complemented with synchrotron-based scattering methods. This way I will be able to fully avoid the usual artefacts of sample varying and hard-vacuum conditions, because the L-C TEM and scattering methods allow for direct in situ characterisation of nano-sized objects in solution with a near-atomic-resolution. This combination of novel techniques will provide unprecedented insights on properties of the molecular building blocks for alumina and silica as they nucleate, grow and assembly with each other.

Keywords: alumina,silica,nucleation and growth,crystallization,electron microscopy,scattering,in situ characterization,saxs,waxs,hexd
Paleozoic Seafloor Spreading (PASS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-04
End date: 2017-09-03
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

It is now recognised that large oceanic detachment faults are fundamentally important along slow-spreading rate portions of the mid-ocean ridge system. These fault systems have been the target of numerous scientific expeditions leading to a new paradigm of “detachment-mode” spreading. However, in the modern oceans this style of spreading can only be documented back to 10-12 Ma. To understand these systems in the deep geological past it is necessary to work on ancient examples of detachment faults in ophiolites, slices of oceanic lithosphere that have been emplaced tectonically onto continental margins and which expose ocean floor structures in 3-D. Recent work in the Mirdita ophiolite of Albania has demonstrated that detachment-mode spreading operated in the Jurassic period. This project will extend this record back to the Palaeozoic, by investigating a detachment system preserved in the Thetford Mines Ophiolite of Canada. An integrated field-based structural and palaeomagnetic investigation will test the hypothesis that this example provides the oldest known analogue for modern oceanic detachment systems. Objectives are to: (i) systematically back-strip successive tectonic events that have affected the ophiolite, in order to recover primary seafloor relationships; (ii) determine whether relative tectonic rotation has occurred across the detachment fault, a defining feature of modern examples; and (iii) quantify the role of large- and small-scale faulting in accommodating displacement within the detachment system. The project will provide: (i) extensive training in field-based tectonic applications of palaeomagnetism, directly complementing the Fellow’s existing expertise and experience in laboratory techniques, thereby allowing her to conduct future investigations in complex tectonic environments; and (ii) engagement with the international oceanic scientific community, opening future opportunities to move into oceanic geodynamic research.

Keywords: oceanic core complex,oceanic detachment fault,ophiolite,ordovician,canada
TItanium COmposite Adhesive JOints (TICOAJO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Greece,Netherlands,Netherlands
Call: Manufacturing of prototype elements for hybridation of titanium and epoxy resin - Characterisation of the Titanium TiCP40 - CFRP adhesive joint (H2020-CS2-CFP03-2016-01, 2016)
Start date: 2017-02-01
End date: 2019-10-31
Duration (months): 33.0
Total project cost (EUR): 694125.0
EU funding (EUR): 694125.0
Participants: 3
Project status: CLOSED

Future aircraft will have to be more fuel efficient in order to accomplish sustainable air transport growth. One of the key enablers to achieve this fuel efficiency is drag reduction by improved aerodynamic efficiency. On its turn, a key enabler within this aerodynamic efficiency is air foil drag reduction by laminar flow control. The relevant technologies involve a hybrid joining of titanium and CFRP for the leading edge design. For a successful implementation of this concept the fracture properties (i.e. strain energy release rates) of this joint must be reliably determined experimentally to pave the way towards more precise numerical tools development for the critical design of such joints. A full experimental characterization of the mode I, II and mixed mode fracture properties of three different joining technologies under quasi-static, fatigue and high strain rate loading in ambient, hot/wet and low-temperature conditions is thus required and targeted in this project. The objectives set and the activities envisaged in TICOAJO are summarized as follows: • Investigate manufacturing parameters to improve properties, focus on pre-treatment of metal and composite parts • Preselect four different joining technologies already verified in industrial level • Manufacture coupons with optimal adhesion characteristics for four union types • Explore joint properties by static testing for all four union types at three environmental conditions (CTD, Ambient, HTW). At high strain rate perform tests at ambient conditions,for the best union type only • Screen for the best union-type and characterize fatigue properties at three environmental conditions (cold-dry, Ambient, hot-wet), resulting in in-depth knowledge of the damage tolerance (DT) capabilities • Validate the coupon results and in-depth DT-knowledge by manufacture two subcomponents, using the best manufacturing technique, predict its damage tolerance capabilities, test it in realistic (ambient) loading conditions, and correlate prediction and result. Perform a static test.

Keywords: fracture properties,hybrid joint,industrial manufacturing,advanced pre treatment,extensive testing
Common mechanisms of host membrane trafficking subversion by intracellular pathogens to rupture bacterial containing vacuoles (EndoSubvert)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: France
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2017-01-01
End date: 2022-12-31
Duration (months): 72.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

A common strategy of bacterial pathogens is active or passive uptake into host cells. There, they can localize within a bacterial containing vacuole (BCV) or access the host cytoplasm through BCV rupture. Hence, intracellular pathogens are often classified as vacuole-bound or cytoplasmic. Recently, this definition has been challenged by the discovery that many vacuole-bound pathogens, including Mycobacterium tuberculosis and Salmonella enterica, access the host cytoplasm, and by the insight that cytoplasmic bacteria, like Shigella flexneri or Listeria monocytogenes, do not always escape the BCV. Despite this increasing complexity, a precise understanding lacks for why and how a pathogen “chooses” between a BCV or the cytoplasm and yet this is very important: because of differential pathogen sensing in membrane-bound and cytoplasmic compartments, intracellular localization leads to induction of different host responses. Therefore, a comprehensive understanding of the processes controlling BCV integrity is not only essential, but can provide new therapeutic targets. Our previous research has implemented innovative fluorescence microscopy to track the invasion steps of pathogenic bacteria. We have further integrated a large-volume, correlative, light/electron microscopy (CLEM) workflow via focused ion beam scanning electron microscopy. This uncovered the subversion of host Rab cascades by Shigella to rupture its BCV. Starting with the Shigella model of epithelial cell invasion, we will delineate the precise molecular mechanisms controlling BCV integrity in different host cell types. We will analyze (i) the scaffolds of host pathways for membrane remodeling, (ii) their subversion by various pathogens, and (iii) their differential regulation depending on pathophysiological conditions. Together, this will allow development of novel, rational antimicrobial strategies and will yield fundamental insight into understudied cell biological mechanisms of membrane trafficking.
INCREASING EXCELLENCE ON ADVANCED ADDITIVE MANUFACTURING (INEX-ADAM)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Austria,Spain,Sweden,Croatia,United Kingdom
Call: Twinning (H2020-WIDESPREAD-05-2017-Twinning, 2017)
Start date: 2018-09-01
End date: 2022-02-28
Duration (months): 42.0
Total project cost (EUR): 997426.25
EU funding (EUR): 997426.25
Participants: 5
Project status: CLOSED

Main goal of the INEX-ADAM project is to reduce networking gaps and deficiencies among UNIZAG FSB and internationally leading EU institutions, by significantly strengthening the excellence and innovative capacity for research in the field of Additive Manufacturing (AM) within the Centre of Additive Technologies (CATeh), as integral part of UNIZAG FSB. INEX-ADAM project will increasing S&T capacity and help raise staff's research profiles in advanced fields of AM through intensive collaboration research with institutions: LTH, MUL, AIDIMME and UBRUN. Project specific objectives will encompass strengthening the synergy among research institutions, strengthening scientific and innovation capacity and raise staff's research profile of the CATeh, within three strategic research domains: Advanced Design for Additive Manufacturing – products and tools, Medical Modelling for Additive Manufacturing and Material Modelling for Additive Manufacturing, and increasing CATeh and UNIZAG FSB, national and international impact and visibility. In INEX-ADAM project, CATeh (UNIZAG FSB) is the participant with needs in advanced knowledge from strategic AM research domains. In order to be able to keep up with world trends in AM field, CATeh researchers will during INEX-ADAM project, through cooperation with project partners, leading international institutions, acquire additional knowledge for advanced application of AM. INEX-ADAM will rely on intensive knowledge transfer and training of CATeh researchers with international leading institutions and their resources as well as on ADAM - joint platform of five EU institutions, project partners. Platform will serve as driver for new level of cooperation, knowledge, expertise and business opportunities through strong synergy effect and impact on all members and stakeholders, thus foster more advanced application of AM in the fields of engineering, design and medicine.

Keywords: advanced additive manufacturing,product topology optimisation,simulation,material modelling,functionally graded materials
Disorders of Consciousness (DoC): enhancing the transfer of knowledge and professional skills on evidence-based interventions and validated technology for a better management of patients (DoCMA)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany,Spain,Italy,Italy,Germany,Italy,Italy,Austria,Austria,Spain,Belgium,Greece
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017, 2017)
Start date: 2018-01-01
End date: 2023-01-31
Duration (months): 61.0
Total project cost (EUR): 1129500.0
EU funding (EUR): 1129500.0
Participants: 13
Project status: CLOSED

The overall goal of DoCMA is to enhance international research on Disorders of Consciousness (DoC) by strengthen the collaboration among project participants to leverage the shared scientific and expert know-how in the field. The partnerships will be instrumental in addressing, therefore, the following specific objectives: Specific Objective 1) Consolidating of a joint international scientific and innovation programme for developing research projects on DoC diagnosis, evaluation and management of patients. Specific Objective 2) Establishing a standardised methodology, common approach and data sharing resources to enable data access and research collaborations concerning DoC. Specific Objective 3) Contributing to transfer of knowledge and quality of life of the individuals, by generating new services, technologies and/or products to respond to the society needs concerning DoC. In short, this action will increase the scientific competence of the consortium members at the international level in DoC research and clinical practice, enhancing the transfer of knowledge and professional skills on evidence-based interventions and validated technology for a better management of patients. To reach the mentioned goal, the partnership is composed by ten partners from different countries in Europe (Austria, Belgium, Germany, Italy, and Spain), covering a wide range of expertise, and bringing together academic and non-academic entities.

Keywords: disorders of consciousness,diagnosis and assessment techniques,prognosis,consensus based care management,non invasive brain stimulation techniques controlled trial
SHOW MOTION: Real time intelligent system for biomechanical motion and muscular diagnosis (SHOW MOTION)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Italy
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-10-01
End date: 2020-01-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The lack of an efficient and affordable solution for assessing the health of a movement and related muscular structures motivated NCS to develop S-HOW MOTION, a very unique and innovative anatomic motion analysis platform, based on wearable sensors, surface electromyography, biomechanical analytics, and virtual model comparison parameters, representing the first objective non-invasive smart tool for musculoskeletal physiotherapy, orthopaedics, pre- or post-surgical rehabilitation, ergonomics and sport analysis applications. S-How Motion's Competitive/Innovative advantages includes: a) Real-time analytics, allowing for a deep on-site understanding of the movement; b) Creation of a Virtual Body model, to be compared with other models, in order to mimic standardized movements (e.g.: healthy/pathological, precise sport movements); and c) Informs about the status and relation between muscular stress and motion, allowing diagnosis and follow up of motion conditions and treatments. S-How Motion market potential is huge since the global Physiotherapy Equipment Market was valued at ~€14 B in 2016, growing at 7.1% CAGR by 2022 and the global 3D motion capture system market is projected to expand at a CAGR of 11.31% to reach ~€155 M by 2022, from €91 M in 2017. A significant share of these two markets combined constitute the target niche of the S-How Motion Platform: In-Depth movement understanding for diagnosis (Physiotherapy, rehabilitation, Orthopaedics), Movement comparison (Sport analysis) and Ergonomic studies (product design and risk prevention). Our business model primarily consists of a sale + maintenance fee for the sensors, and a monthly fee for the cloud servers. We have estimated that in 5 years after the end of Phase 2 project, we would have accumulated ~406 S-How Motion tools sales (revenue €39M) accounting for ~1% of the EU and USA market. We expect to hire ~40 new technical and sales employees and earn ~€16.5M profit, thus generating a ROI of 6.2%.

Keywords: motion analysis,sensors,surface electromyography,3d modelling,data screening algorithms,treatment efficacy assessment,ergonomics,high level sport
Empowered control of drugs's dosage in chronic diseases. (INSULCLOCK)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-06-01
End date: 2015-10-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

INSULCLOCK addresses the opportunity of providing a new product within the growing market for diabetes care, a very serious and painful disease with an expected global patient pool of 380 million by 2025. More specifically, INSULCLOCK approaches the insulin pens market which totaled above 8 billion € in 2013, with a 9% CAGR for the next years. More than 25% of diabetics depend on insulin injections daily, and it is estimated that two-thirds of insulin volume is injected via a modern pen devices. In case treatment fails, there is high risk of complications related to vascular and nerve affection and even death. The goal of our project is to launch market uptake of INCULCLOCK, an integral solution to really help diabetics and their caregivers in self-managing their disease. Thanks to the unique integration of smart electronic devices and mobile&wearable technologies, we create new demand both from patients already using insulin pens and those not doing so because of reliability issues. Also, around their caregivers, not involved today in business, creating an uncontested market space. In the current market there are smart/memory insulin pen devices however several reasons make INSULCLOCK really unique: 1. It automatically records all critical information related to insulin in-taking for diabetes treatment. 2. It stores data taking full advantage of possibilities offered by the Cloud and mobile application technologies, assuring security and privacy. 3. It integrates wireless communication. 4. It is universal, reusable and even smaller and lighter than competitors. 5. It fulfils these advantages altogether. We plan to undertake detailed studies for identifying key action points for the internationalization and growth of the company as well as industrialization process, purposes of Phase 2, for which we estimate a total budget of 1M€ for 12 months. In Phase 3 we will focus in further private investment.

Keywords: medical device,insulin pens,treatment management
A Sustainable Soil Solution: Scaling up Novihum, an innovation to convert bad soil into better, make brown coal clean and barren land green, and profitably advance food security in Europe and beyond (Scaling up Novihum)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Germany
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-2-2015, 2015)
Start date: 2015-12-01
End date: 2018-05-31
Duration (months): 30.0
Total project cost (EUR): 3468000.0
EU funding (EUR): 2427600.0
Participants: 1
Project status: CLOSED

Soil is a vital – though often neglected – tool for increasing the resilience and security of food production, as recognized by the UN’s declaration of 2015 as the International Year of Soils; improving it can reduce erosion and enhance drought tolerance, crop yields, water and nutrient efficiency, and long-term land fertility. Novihum is a uniquely scalable innovative soil conditioning technology that replaces natural humus in degraded and arid soils, significantly increasing crop yields while reducing water use and pollution. It is produced by enriching abundant lignite (brown coal) in a highly efficient industrial process, and is affordable, easy to use, long-lasting (>10 years), and good for the environment. Its unique set of properties make it novel to the market and highly competitive with all other soil conditioners, which are typically difficult to use, transport, or scale up. Novihum Technologies GmbH was founded in 2012 to commercialize the patented technology, and has attracted venture capital investment from the EU and US. The objective of the Project is to scale up the Novihum production technology from prototype to a Pilot Facility in Germany, where an industrial production line suitable for scaling up to profitable commercial scale can be tested and refined. It will also demonstrate Novihum’s high-value impacts to potential customers and expand the product line. It will result in the know-how and proof of performance necessary to scale up to commercial production, and a sophisticated global customer and partner network that will facilitate successful market entry. The commercial potential for Novihum is very large – as are its impacts on the security and resilience of food production and on the environment – with more than 3.5 million sq km of land in need of its benefits and expected global annual sales of up to EUR 360 million in the agriculture, horticulture, recultivation, urban farming, and landscape sectors in the EU, US, and Middle East.

Keywords: soil fertility,food security,recultivation,carbon sequestration,clean coal,eutrophication,desertification,climate change