Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Terrace Archaeology and Culture in Europe (TerrACE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Austria,Spain,Italy,Norway,Belgium,United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-12-01
End date: 2024-05-31
Duration (months): 66.0
Total project cost (EUR): 2681429.0
EU funding (EUR): 1757066.5
Participants: 7
Project status: SIGNED

Large areas of agricultural terracing have been abandoned and are being destroyed in Europe. TerrACE will develop a transferrable methodology of archaeological protocols for understanding the creation, maintenance and use of terraces over the longue durée, thereby informing strategies for the sustainable management of these environmental-fragility hotspots. Terraces and lynchets are hallmarks of complex Prehistoric to Post-Medieval societies and were critical for the sustainability of many European societies (including the Greeks & Romans). However, we typically know less about them than any other archaeological site type, although they were one of the first transformations of natural into cultural landscapes, which in many cases persisted to the 20th century. Key archaeological questions are: how old are terrace systems, how were they used, did they reduce soil erosion and are they carbon sinks? The answers to these questions have high relevance in Europe today as terraces can combine high yields with decreased erosion and fire risk, whilst increasing social resilience and food security in the face of environmental change. TerrACE will be a step-change in our archaeological approach by integrating a raft of new and innovative scientific techniques through an exemplary study of the creation, operation and abandonment of terraced landscapes on a N-S climatic transect of well-known/excavated terraces across Europe. TerrACE has 5 objectives; 1) improving terrace-landscape mapping, 2) multiple dating typical terrace systems, 3) determining history of use and management, 4) understanding the role of terraces in carbon storage, and 5) outreach to promote terraces as part of Globally Important Agricultural Heritage Landscapes (UNESCO GIAHS). TerrACE is only now feasible due to the development of techniques including LiDAR, direct sediment dating, palaeoenvironmental proxies, soil carbon modelling and the innovatory use of ancient DNA on terrace palaeosols.

Keywords: environmental history,complex societies,social change,palaeoecology,archaelogical survey,biomolecular methods,sediment dating,agricultural history,rural sustainability
Service Design for Innovation (SDIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Germany,Italy,Germany,Sweden,Sweden,Netherlands,Netherlands,United Kingdom,United Kingdom,Portugal,Portugal,Portugal
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 2283926.12
EU funding (EUR): 2283925.68
Participants: 14
Project status: CLOSED

Service Design for Innovation (SDIN)-ETN aims to integrate service design and service innovation approaches that are now dispersed into an innovative research training framework; doing so leverages the creative power of service design to foster innovation. Specific objectives are: creating a mass of researchers who can drive widespread application of service design to leapfrog innovation in European organisations; and developing interdisciplinary competences in the key SDIN area and in key service sectors -ICT, public services and utilities. SDIN training programme comprises: individual research projects with interdisciplinary supervision (design and management) and non-academic involvement; substantial non-academic training (through hosts and secondments); development of competences in at least one key service sector, with exposure to other sectors; and network wide training with innovative courses, workshops, transferable skills training, and network wide training events. A strong consortium with unique combination of expertise will implement SDIN. Academic beneficiaries provide a rich training experience and research competences in service design and service innovation. The three non-academic beneficiaries are innovation leaders in ICT, public services and utilities, providing a rich ground for application of SDIN results to multiple sectors. SDIN will have significant impacts on ESRs, partners, and the pursuit of the Innovation Union: SDIN will develop interdisciplinary and multi sectorial competences in ESRs, which are highly valued and have a strong innovation impact on organisations. Beneficiaries will integrate their expertise to build enduring interdisciplinary and multi-sector competences in SDIN. SDIN’s extensive dissemination will ensure that the results achieved are shared with wider communities, thus producing spill over effects to other sectors. SDIN can make a significant and timely contribution to the Innovation Union strategy.

Keywords: service design,service innovation,service research,service development,value co creation,complex service systems,design research
Leukocyte immunoglobulin-like receptors (LILRs) on neutrophils (NEUTRO-LILR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-03
End date: 2018-10-02
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Neutrophils provide the first-line of antimicrobial defence and orchestrate inflammation. They are tightly regulated by ligand-receptor interactions to ensure pathogen clearance and to prevent host damage. Targeting receptors, with natural or synthetic ligands, that control neutrophil functions is a promising strategy to control infections and inflammation. However, basic knowledge on the role of certain receptors in neutrophil biology, and their interactions with pathogens, has been neglected. This includes leukocyte immunoglobulin-like receptors (LILRs), a family of surface receptors that are potent regulators of immune cell activity and potential targets of immunotherapeutic strategies. The major aim of this project is to comprehensively understand how LILRs regulate neutrophil functions, to identify bacterial ligands of LILRs and to test whether each bacteria-derived LILR ligand has pro- or anti-inflammatory properties that could be exploited in future immunotherapeutic strategies. For the first time, we will extensively characterise the functional role of four representative LILRs in controlling neutrophil functions. We will screen our newly developed high-throughput bacteria secretome phage display libraries, representative of 20 pathogens and the entire human gut microbiome, for identifying bacterial molecules that bind to LILRs. Finally, we will determine whether each of the ligands acts as a LILR agonist or antagonist. These experiments build upon expertise and preliminary results of the applicant, and upon unique resources of the host. The proposed experiments will expand knowledge of the function of poorly studied LILRs on neutrophils. This will advance knowledge of neutrophils, immune responses and bacterial pathogenesis, paving the way for identifying new strategies for treatment of infection and inflammation.

Keywords: neutrophils,immune receptors,host pathogen interactions,staphylococcus aureus,escherichia coi
Outsourcing cancer immunity to healthy donors (OUTSOURCE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Norway
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 2
Project status: SIGNED

Despite recent advances in cancer immunotherapy, most patients with metastatic cancer are not cured. Major reasons are lack of homogeneously and highly expressed molecules that can be safely targeted and evoke efficient T-cell responses. I propose that the strong T-cell responses leading to rejection of transplanted organs can be exploited to “reject” cancer by specific recognition of tissue-restricted targets. To this end, I recently demonstrated that healthy donor blood provides a rich source of T cells expressing TCRs that specifically and strongly react to peptides from tissue-restricted self-proteins, when presented on mismatched, foreign Human Leukocyte Antigens (HLA). I propose that patient T cells genetically equipped with such donor TCRs (dTCR T cell therapy) may “reject” cancer-affected organs, including metastases. A high and homogeneous expression of tissue-specific antigens is often maintained on both primary tumor and metastatic cancer cells. Here, I will identify peptides from tissue-restricted proteins as novel candidate TCR targets. Next, I will identify donor T cells that recognize such self-peptides in complex with foreign HLA by use of my patented method, and sequence reactive TCRs. Finally, I will establish a preclinical pipeline to characterize safety and efficacy of TCRs in vitro and in vivo in innovative mouse models. Outsourcing cancer immunity to dTCR T cells may bypass major limitations in current immunotherapies, including checkpoint inhibition and T cells gene-modified with chimeric antigen receptors (CARs). Thus, dTCRs can recognize i) intracellular targets and thus manifold more targets than CARs, ii) tumor-associated self-antigens with high affinity in contrast to patient-derived TCRs, and iii) self-antigens, which are more homogeneously expressed than mutations. dTCR T cell therapy could treat malignancies in organs that are non-essential for survival, such as prostate, or that can be replaced by a transplant, such as bone marrow.

Keywords: cancer immunotherapy adoptive t cell therapy t cell receptor engineered t cells
Chirality via Cross-Coupling: New Asymmetric C-C Bond Formations Driven by Atom and Step Economy (ChiCC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure-properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1999890.0
EU funding (EUR): 1999890.0
Participants: 1
Project status: SIGNED

Over 60% of the world’s top selling small molecule drug compounds are chiral and, of these, approximately 80% are marketed as single enantiomers. Surprisingly, and despite the tremendous advances made in catalysis over the past several decades, the average “chiral complexity” of drug discovery libraries has actually decreased, while, at the same time the “chiral complexity” of marketed drugs has increased. Consequently, there is now an urgent need to provide efficient processes that access directly privileged chiral “3D” building blocks. It is our philosophy that catalysis holds the key here and new processes should be based upon atom and step economical platforms that exert control over both absolute and relative stereochemistry. Palladium catalysed cross-coupling reactions of aryl (pseudo)halides with organo-nucleophiles (esp. the Suzuki coupling) have become mainstays of the pharmaceutical industry. Here, multiple “concession” steps are usually required to prepare the reaction partners, thereby detracting from atom and step economy. Further, these processes predominantly provide planar “2D” structures and are not well suited to the production of chiral “3D” building blocks. Consequently, methods that allow feedstock precursors (e.g. alkenes and aryl C-H bonds) to be combined directly in enantioselective or enantiospecific C-C bond formations are highly desirable. Cross-couplings of this type would circumvent “concession” steps, thereby minimising cost, effort and waste; however, such processes are highly challenging because of issues associated with regio- and stereocontrol. Recently, we developed prototype catalyst systems that can address this. In the proposed ERC project, these exciting preliminary results will be developed into a wider family of processes where asymmetric C-C bond formations are achieved directly by C-H activation. The new methods, which fulfil modern reaction ideals of atom and step economy, will likely find broad use in applied settings.

Keywords: synthetic methodology,cross coupling,enantioselective,catalysis,atom and step economy
Scale-up of INNER MAGIC and INNER REFLECTION: Virtual Ultrasound Sensors for Smart Devices. (IMIR-UP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Norway
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2019-02-01
End date: 2020-05-31
Duration (months): 16.0
Total project cost (EUR): 3087495.0
EU funding (EUR): 2161246.5
Participants: 1
Project status: CLOSED

Smart device manufacturers require constant innovation in order to improve their products while simultaneously reducing costs. Hardware-based solutions are expensive, requiring dedicated sensors and long deployment times to fully integrate them into devices, since they must be manually tuned and calibrated for each new type of application. This makes it difficult to customise such devices for different market segments and end-user needs. Furthermore, extra hardware requirements often compromise a device’s design, increasing their bulk and rendering them old-fashioned. Many hardware-based solutions also increase the risk to a user’s privacy and data security, such as those solutions involving cameras. As a result, manufacturers are adopting software-only solutions instead of hardware. However, they do not yet have a presence detection or gesture recognition solution ready for mass commercialization. Elliptic Labs is the world leader in ultrasound sensing software for smart devices, enabling touchless interactions and gesture interpretation. INNER MAGIC and INNER REFLECTION (IMIR products) are the first-of-their-kind integrated solutions for non-intrusive user presence detection and intuitive gesture recognition, transforming smart devices into genius devices. The aim of the IMIR-UP Phase 2 project is to fully mature our award-winning and patented technology for easy, mass-scale (“plug-n-play”) deployment in any consumer electronic smart device without requiring supplemental hardware (software only). Bringing our innovative IMIR products to the mass market will positively disrupt existing touchless sensing technologies, resulting in an improved user ability to intuitively interact with their smart devices via a natural extension of normal human behaviour. We estimate that we will reach 651.21m smart devices (just 2.87% of our TAM) after the first 5 years of commercialisation, representing accumulated revenues and gross profits of €195.36m and €105.15m, respectively.

Keywords: gesture recognition,presence sensing,smart device manufacturers,consumer electronics,touchless control,user experience,interactive,software only,ultrasound,privacy,speaker,microphone
Breeding Invertebrates for Next Generation BioControl (BINGO) (BINGO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria,Germany,Germany,Italy,Spain,Greece,France,Czechia,Netherlands,Netherlands,Netherlands,United Kingdom,Portugal
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 3288069.0
EU funding (EUR): 3288069.0
Participants: 13
Project status: CLOSED

BACKGROUND Secure and sustainable food production in terms of quantity and quality is a major challenge facing human societies. However, food security is continuously threatened by current and invasive pest species. EU regulations for the use of pesticides are getting stricter to ensure food safety and protect ecosystem health. Biocontrol of agricultural pests by using natural enemies has great potential to deal with these two demands. CHALLENGE Controlling novel exotic pests often involves importing non-native natural enemies. Such practices are undesirable as it poses risks to local biodiversity. Optimizing existing and native biocontrol agents can reduce the dependence on imported natural enemies. OBJECTIVE BINGO will advance current knowledge in biocontrol practice through the use of natural genetic variation and by simultaneously training 13 young researchers in an extensive suite of interdisciplinary skills. This will allow them to improve the efficiency of biological pest control through selective breeding of natural enemies in a broad range of agricultural systems and environmental conditions. HOW The research projects will address current bottlenecks in biocontrol, for rearing, monitoring and performance, that include a broad range of scientific disciplines and in which state-of-the-art population genomics will be applied. Industry has a pivotal role by providing the problems for research, training, and by translating the results to capacity building and increased competitiveness. RELEVANCE BINGO will deliver improved biocontrol agents, knowledge on the genetic organisation of traits related to agents’ performance, genetic markers for monitoring and risk assessment, and guidelines and protocols for genetic improvement of natural enemies. Crucially, BINGO will deliver eager ESRs that have the potential to thrive in professional environments in science, industry and public bodies to ensure that the biocontrol potential is met and implemented.

Keywords: biocontrol,pest management,sustainable agriculture,life history of natural enemies,population genomics,genetic markers,risk and monitoring,genetic improvement
Concerted Action EED - Support to Member States and participating countries for the implementation of the Energy Efficiency Directive (CA-EED 2)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: Coordination and support actions
Countries involved: Austria,Germany,Germany,Spain,Estonia,Ireland,Italy,Cyprus,Malta,Poland,Norway,Belgium,Bulgaria,Croatia,Hungary,Lithuania,Romania,Slovakia,Slovenia,Sweden,Greece,Finland,Latvia,France,Czechia,Netherlands,Denmark,Luxembourg,Portugal,United Kingdom
Call: Concerted Action EED: support to Member States and participating countries for the implementation of the Energy Efficiency Directive (H2020-IBA-Energy-EED-2016-17-1, 2016)
Start date: 2017-04-15
End date: 2022-05-14
Duration (months): 61.0
Total project cost (EUR): 4696181.6
EU funding (EUR): 4696181.6
Participants: 32
Project status: CLOSED

The objective of the 2nd Concerted Action for the Energy Efficiency Directive (CA-EED 2) is to foster exchange of information and experience among Member States and other participating countries (Norway) with a view to facilitating to the implementation of the Directive 2012/27/EU of the European Parliament and of the Council on energy efficiency (EED), including the implementation of the foreseen re-cast of this Directive. The specific objectives of the Action are: • To enhance and structure the sharing of information and experiences from national implementation whilst promoting good practice concepts in activities to improve and strengthen MS implementation of the EED. • To encourage dialogue between MS on common approaches for the effective implementation of particular parts of the EED. • To complement the work of the EED Committee assisting the European Commission. The expected impact of the Action consists of a more harmonized approach and improved implementation of the EED in all MS, as well as the transfer of good practices between countries. The objectives of the CA-EED 2 will be achieved by organising information exchange via amongst others 8 structured plenary meetings for coverage of the various topics. The meetings will allow experts from implementing bodies and ministries in the MS to discuss and exchange views, and aim to achieve as much convergence of objectives and methodologies as appropriate, avoiding redundant efforts and maximizing the benefits that can be obtained from the work otherwise required from individual MS working on their own. A large part of the work in the CA-EED 2 will be done in the sessions during the plenary meetings, focussing on good practice examples, but also through Working Groups that interact between the meetings and exchange of information through the forum on the CA-EED website. In order to structure the topics covered by the EED Expert Areas have been identified encompassing the main areas of the EED.

Keywords: energy efficiency,energy,directive,member states,implementation