Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Self-reported vision status and associated risk factors in Europe: prevalence and temporal change (EUROVISION)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-09-17
End date: 2020-09-16
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The European Coalition for Vision (ECV) exists to raise the profile of eye health and vision, help prevent avoidable visual impairment and secure an equal and inclusive society for those with irreversible blindness or low vision in Europe. Members of the group have assessed the evidence base for prevalence of vision impairment and blindness in Europe [ref: Bourne, Jonas et al. Br J Ophthalmol 2014 May;98(5):629-38] by collating prevalence data from all population-based surveys of eye disease. While these efforts have established estimates of numbers of people affected by vision loss, we are unaware of the self-reported visual problems of European Union citizens. This Research Fellowship (supported by ECV) will involve analysis of Eurostat data which provides an opportunity for us to investigate the prevalence of self-reported visual difficulties and also to relate this to potential risk factors that are also collected by the Eurostat program. The primary objective is to estimate the prevalence of self-reported distance and near vision impairment in Europe, and change over past 10 years. Secondary objectives include estimation of prevalence of refractive correction in Europe, demographic, environmental and healthrelated risk factors for self-reported vision loss and to investigate the association between self-reported vision loss and selfreported hearing loss. Additionally, access to health services for those with these impairments will be investigated. This is relevant given the importance of social inclusion in European policies of health goals and universal health coverage. The Fellow will be supported by Professor Rupert Bourne, who coordinates the Vision Loss Expert Group of the Global Burden Disease Study, in Cambridge, UK, and a team of researchers that include bioinformatics, public health and statistics expertise at Anglia Ruskin University with collaborations with Queens University Belfast and University of Ulster.

Keywords: eye health,vision,visual impairment,eurostat data,self reported vision loss,access to health services,social inclusion
Diagnosing platform for neurological and mental disorders based on the analysis of ocular and oculocephalic movements. (OSCANN)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: Spain
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The first product that AURA will launch to the market will be OSCANN, a diagnosis platform that will allow better, faster and more accurate diagnosis of neurological disorders affecting Europe’s population in general, but specially youngsters (e.g. ADHD) and elders (e.g. Parkinson). OSCANN allows for the measurement and analysis of ocular and oculocephalic movements (OM/OCM) and combines the result with data obtained from other sources (clinical histories, medical explorations, complementary tests and biomarkers) using Artificial Intelligence (AI) techniques to improve significantly the quality of medical diagnosis in early stages.

Keywords: diagnostics,biomarkers,medical devices,mental disorders
Astronomy ESFRI and Research Infrastructure Cluster (ASTERICS)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Spain,Spain,Spain,Germany,Germany,Italy,France,France,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Implementation and operation of cross-cutting services and solutions for clusters of ESFRI and other relevant research infrastructure initiatives (H2020-INFRADEV-1-2014-1, 2014)
Start date: 2015-05-01
End date: 2019-04-30
Duration (months): 48.0
Total project cost (EUR): 14991194.0
EU funding (EUR): 14991194.0
Participants: 31
Project status: CLOSED

ASTERICS (Astronomy ESFRI & Research Infrastructure Cluster) aims to address the cross-cutting synergies and common challenges shared by the various Astronomy ESFRI facilities (SKA, CTA, KM3Net & E-ELT). It brings together for the first time, the astronomy, astrophysics and particle astrophysics communities, in addition to other related research infrastructures. The major objectives of ASTERICS are to support and accelerate the implementation of the ESFRI telescopes, to enhance their performance beyond the current state-of-the-art, and to see them interoperate as an integrated, multi-wavelength and multi-messenger facility. An important focal point is the management, processing and scientific exploitation of the huge datasets the ESFRI facilities will generate. ASTERICS will seek solutions to these problems outside of the traditional channels by directly engaging and collaborating with industry and specialised SMEs. The various ESFRI pathfinders and precursors will present the perfect proving ground for new methodologies and prototype systems. In addition, ASTERICS will enable astronomers from across the member states to have broad access to the reduced data products of the ESFRI telescopes via a seamless interface to the Virtual Observatory framework. This will massively increase the scientific impact of the telescopes, and greatly encourage use (and re-use) of the data in new and novel ways, typically not foreseen in the original proposals. By demonstrating cross-facility synchronicity, and by harmonising various policy aspects, ASTERICS will realise a distributed and interoperable approach that ushers in a new multi-messenger era for astronomy. Through an active dissemination programme, including direct engagement with all relevant stakeholders, and via the development of citizen scientist mass participation experiments, ASTERICS has the ambition to be a flagship for the scientific, industrial and societal impact ESFRI projects can deliver.

Keywords: esfri,astronomy,astroparticle physics,km3net,big data,science 2 0,virtual observatory,citizen science
SCIENCzEch 2021: Time for Change (SCIENCzEch 2021)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Czechia
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020bis, 2020)
Start date: 2021-05-01
End date: 2022-02-28
Duration (months): 10.0
Total project cost (EUR): 199000.0
EU funding (EUR): 198575.0
Participants: 1
Project status: CLOSED

SCIENCzEch 2021: Time for Change is a proposal of The European Researchers? Night in the Czech Republic in 2021. The common main objective of the European Researchers' Night is to give public and local communities the opportunity to meet with researchers, learn about their passion for science, the motivation that inspires them, the methods they use, and the results they achieve. It opens doors to the places where scientists work and also brings research to unusual places. At this event children, young people and adults can get insights into research work, careers and what kind of cutting-edge technology is used in modern research. The specific objective of the event is to show research careers as interesting, enriching and useful job that might entail a career path for everyone and to motivate and inspire the youth to enjoy, understand and pursue science and technology. One of the political priorities of the European Commission is the European Green Deal for the European Union and its citizens, with an aim to tackle climate and environmental-related challenges. This strategy and series of initiatives that will protect the environment, boost the green economy and improve the well-being of people under the European Green Deal for the European Union and its citizens will be promoted by a wide range of activities during the ERN 2021. . "The TIME" with subtitle ?TIME for Change? is going to be the main topic for the Researchers' Night in 2021. The topic refers to the to time in many ways. We are in a time of change, the situation with COVID-19 has shown us how vulnerable a global society is. At the same time, we are facing problems linked to climate change and environmental crises. We question how much time is left for our planet and how to deal with this time responsibly. We perceive that right now is the time for change and science is an important ally and condition for sustainable development.

Keywords: european researchers night,european green deal,science career,popularization of science
Unique patented technology for recycling mixed plastic waste and other hard-to-recycle waste streams to REMATerialize them to valuable products (REMAT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-EIC-SMEInst-2018-2020-3, 2019)
Start date: 2020-03-01
End date: 2022-03-31
Duration (months): 25.0
Total project cost (EUR): 3358281.25
EU funding (EUR): 2350796.88
Participants: 2
Project status: CLOSED

WIMAO is flipping the “take, make and dispose of” model on its head with REMAT: a breakthrough process to repurpose 230 millions of tons of plastic waste that are being sent to landfills and incinerators every year. Furthermore, countries where we have been previously been exporting the majority our waste have put a ban on the import of foreign waste which means than billions of tons of waste have nowhere to go and threaten EU’s ambitious targets to recycle up to 75% of waste by 2023. Our patented recycling technology gives second life to these plastic waste streams in the form of new composite products that have the same properties as the billions of cubic meters of products manufactured every year from virgin raw materials. WIMAO is uniquely positioned to create a new standard operating mode for the recycling industry because we have the only technology versatile enough to handle the volumes of waste that Material Recovery Facilities (MRF) collect exactly as they receive it, without the need to separate waste streams, effectively surmounting the key barrier for recycling. We already have developed a proof of concept REMAT plant that started production in January 2019 turning mixed plastic waste that is not wanted by the plastic recycling industry and wood waste into composite decking tiles and half euro pallets. Now we are preparing to develop the next generation of our technology to 1) consistently process new types of plastic waste streams 2) manufacture larger and more complex composite products and 3) create automated process controls to accommodate fluctuations in waste materials. This will set the stage for licensing our technology where we expect to have 26 plants and modules diverting 168,000 tons of waste per year from landfills and generating €48.75M in turnover for Wimao by 2024.
Water, Sanitation and Hygiene in sub-Saharan Africa: Understanding Policy and Practice (WaSH-UPP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-08-15
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Science underpins Water, Sanitation and Hygiene (WaSH) policies by promoting improved understanding of ‘processes’ and ‘practices’ and providing evidence enabling effectiveness, or ‘impact’ to be evaluated. However, knowledge exchange between stakeholders rarely runs smoothly, without translational challenges. This project, ‘Water, Sanitation and Hygiene: Understanding Policy and Practice’ (WaSH-UPP) will explore the grand challenge of ‘water and sanitation for all’, recently codified in UNESCO’s Sustainable Development Goal 6 with particular focus on sub-Saharan Africa (SSA), exploring how formal and informal institutions intersect to shape policy practices. This will be achieved through comparative analysis of two globally significant exemplars (Nigeria and Malawi) (i) mapping the critical actors in the WaSH-UPP-nexus;( ii) evaluating the features of science-policy discourse in both countries; (iii) revealing knowledge co-production practices; and (iv) elaborating how institutional processes interact to shape change. Despite the centrality of WaSH to human wellbeing and societal development, widespread improvements in practices in SSA remains slow, with well-recognized barriers including cultural/religious beliefs, weakly developed water services infrastructure and socio-economic factors including gender relations. WaSH-UPP will use a range of discourses, theories, and methods to compare issues across diverse field contexts. A five month secondment (split into two phases) to the Scottish Government’s Hydro Nation Scholars Programme in the SG Water Industry Team in Edinburgh. This will enable a broadening of the WaSH stakeholder base to include international innovation services and draw in expertise from small-medium and micro-enterprises that help bridge capacity gaps leading to greater impact. A WaSH science-policy context for each country will be developed to draw out commonalities/differences as a diagnostic to answer what is working, and what is not, and why.

Keywords: water management
Safe human-robot interaction in logistic applications for highly flexible warehouses (SafeLog)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Robotics SPARC (cPPP)
Countries involved: Germany,Germany,Germany,Croatia,Czechia
Call: Robotics (H2020-ICT-2015, 2015)
Start date: 2016-01-01
End date: 2020-12-31
Duration (months): 60.0
Total project cost (EUR): 4618462.5
EU funding (EUR): 4618462.5
Participants: 6
Project status: CLOSED

The European market for e-commerce is growing rapidly, with more than 16% just in the year 2014. With the internationalization of distribution chains, the key for success lies within efficient logistics. In such facilities, goods for the end-user or products in the B2B sector are stored, commissioned and shipped. To manage the supply chains, many new warehouses have been erected and more will follow. With the growing markets, the need for larger warehouses and their automation increases. To advance the position of the European trade sector, technical restrictions on the size of warehouses should be avoided and new automation paradigm should be implemented to ensure their efficient operation. Therefore the European robotic and automation companies should be able to provide appropriate solutions, making scalable systems and scalable software mandatory. Current automation solutions based on strict separation of humans and robots cannot provide such efficient operation of large warehouses. SafeLog aims to overcome this issue by enabling much more efficient warehouse concepts joining human and robot workforce. Given that, the overall objective of SafeLog is the conception and implementation of a large-scale flexible warehouse system which enables safe and efficient collaboration of humans and robots in the same area and at the same time. On the way to reach this objective SaveLog will develop, integrate and test: (1) a holistic and certifiable safety concept based on the safety vest, which allows the collaboration of robots and humans in a flexible warehouse system, (2) planning and scheduling algorithms for a heterogeneous fleet manager, which allow the adhoc reactive planning and scheduling for human and robot workforce in a flexible warehouse system, and (3) augmented reality based interaction strategies to support workers in a robotized warehouse system with information about their current task and environment.

Keywords: multi robot planning,planning of heterogeneous agents
INTEGRATION OF PLANT ORGANELLE COMMUNICATION UNDER ENVIRONMENTAL STRESS (IN-PLANTO_CUES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-03-12
End date: 2020-03-11
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

Environmental challenges such as drought, temperature and light extremes can impose oxidative stress in multiple organelles, thus negatively affecting the function of plant cells. Both chloroplasts and mitochondria can invoke signaling pathways to the nucleus that trigger stress responses and adjustment of cellular homeostasis, resulting in physiological outcomes such as enhanced stress tolerance, or conversely programmed cell death. These pathways include the 3'-phosphoadenosine 5'-phosphate (PAP)-SAL1 pathway for chloroplasts and the ANAC013 mobile transcription factor for mitochondria. However, the mechanisms by which plant cells coordinate different signals from chloroplasts and mitochondria for whole-cell acclimation to oxidative stress are still enigmatic. Whether there is any cross-talk between chloroplast and mitochondrial signaling is also intriguing. My project will investigate these fundamental questions using an exemplar model system consisting of three components that combine my research with the Hosts’. The first goal is to take my PNAS findings that SAL1 is a redox-regulated initiator of chloroplast signaling and determine if a similar mechanism occurs in the mitochondria, where SAL1 is also localized. This would reveal how two distinct organelles can integrate oxidative stress sensing and response by using the same pathway. Second, the interaction between SAL1-redox sensing and the mitochondrial signaling transducer ANAC013 will be investigated to understand integration between these two apparently distinct pathways. Third, ANAC013 targets a biosynthetic enzyme for PAP hinting at crosstalk between mitochondrial and chloroplast signaling at the level of signal metabolism. Thus, my research on SAL1-PAP and VIB’s on ANAC013 collectively present a unique opportunity to reveal how the two pathways are linked at different levels enabling cellular signaling to be coordinated across scales to facilitate a harmonic, not discordant acclimation response.

Keywords: retrograde signalling,drought,high light,plant cell responses to environment,oxidative stress,redox regulated protein
Rational combination therapies for metastatic cancer (CombaTCancer)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Austria
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-03-01
End date: 2024-05-31
Duration (months): 75.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Targeted therapy (TT) is frequently used to treat metastatic cancer. Although TT can achieve effective tumor control for several months, durable treatment responses are rare, due to emergence of aggressive, drug-resistant clones (RCs) with high metastatic competence. Tumor heterogeneity and plasticity result in multifaceted resistance mechanisms and targeting RCs poses a daunting challenge. To better understand the clinical emergence of RCs, my work focuses on the poorly understood events during TT-induced tumor regression. We recently reported that during this phase drug-responsive cancer cells release a therapy-induced secretome, which remodels the tumor microenvironment (TME) and propagates disease relapse by promoting the survival of drug-sensitive cells and stimulating the outgrowth of RCs. Consequently, intervening with combination therapies during the tumor regression period has the potential to prevent the clinical emergence of RCs in the first place. Here, we outline strategies to (1) understand how RCs emerge and (2) to leverage our findings on the TME remodeling for combination therapies. First, we will develop a novel and innovative parental clone-lookup method, that will allow us to identify and isolate treatment-naïve, parental clones (PCs) that gave rise to RCs. In functional experiments, we will assess (i) whether PCs were already resistant before or developed resistance during TT, (ii) whether PCs have a higher susceptibility to develop resistance than random clones, and (iii) the mechanistic basis for metastatic competence in different clones. Second, we will study the TT-induced TME remodeling, focusing on the effects on tumor vasculature and immune cells. We will utilize our results to target PCs and RCs by combining TT in the phase of tumor regression with other therapies, such as immunotherapies. Our study will provide new mechanistic insights into the biological processes during tumor regression and aims for novel therapeutic strategies.

Keywords: metastasis,tumor microenvironment,targeted therapy,therapy resistance
The Enterprise Europe Network Baden-Wuerttemberg - Feeding the Innovation Pipeline in Baden-Wuerttemberg through targeted services to SME (BW-KAM3)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Germany,Germany,Germany,Germany,Germany,Germany
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 275278.0
EU funding (EUR): 275278.0
Participants: 10
Project status: CLOSED

By providing Key Account Management and Enhanced Innovation Management Capacity services, the overall objective of the BW-KAM3 project is to enhance the innovation management capacity of SMEs in the geographical region of Baden-Württemberg, Germany, which is also the geographical area covered by the Enterprise Europe Network Baden-Württemberg. BW-KAM3 will target SME beneficiaries in the SME Instrument, which are located in Baden-Württemberg as well as high potential SME with strong innovation activities and high potential for internationalisation and growth.

Keywords: innovation management