Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mechanism-Based Integrated Systems for the Prediction of Drug-Induced Liver Injury (MIP-DILI)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative
Action type: Collaborative project
Partnership: IMI (Art-185)
Countries involved: Sweden,United Kingdom,Netherlands,Germany,Hungary,France,Belgium,Netherlands,Sweden,France,Germany,Germany,Germany,United States,France,Belgium,Denmark,Germany,Finland,France,Netherlands,Germany,United Kingdom,United Kingdom
Call:  (IMI-JU-03-2010, 2010)
Start date: 2012-02-01
End date: 2017-03-31
Duration (months): 62.0
Total project cost (EUR): 32319866.0
EU funding (EUR): 15335538.0
Participants: 28
Project status: CLOSED

The current test systems employed by Industry are poorly predictive for Drug induced liver injury (DILI). The ‘MIP-DILI’ project will address this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological relevance to DILI in humans. An iterative, tiered approach with respect to test compounds, test systems, bioanalysis and systems analysis will be adopted to evaluate existing models and develop new models that can provide validated test systems with respect to the prediction of specific forms of DILI and further elucidation of mechanisms. The approach will encompass completely characterised cell lines, well-defined and physiologically stable hepatocytes, multi-cell type in vitro models including novel bioreactors, animal models and appropriate ex vivo human cell models. A systematic analysis of data and iteration at each stage will select the ‘best’ cell line, animal model or pathway for further investigation moving from simple systems to more complex models with reference to relevant clinical and preclinical data on the various forms of DILI. Triangulation of human, in vitro and animal data will provide a fundamental understanding of how drugs can harm the liver. It will then be possible to define the application of each particular novel test system in the context of drug development, and its use in the prediction of liabilities associated with the various forms of DILI that occur in man. Just as importantly, the project will define those models that are not appropriate as decision-making tools for the prediction of DILI in man. The MIP-DILI consortium contains Key Opinion Leaders from academia, the biotechnology sector and the pharmaceutical industry in the fields of drug development, drug metabolism, drug toxicology, drug hypersensitivity, liver immunology, liver cell biology, pharmacogenetics, systems biology and clinical adverse drug reactions.

Keywords: drug-induced liver injury,improved predictive models,integrated chemistry and function,mechanisms
Chemical Manufacturing Methods for the 21st Century Pharmaceutical Industries (CHEM21)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Innovative Medicines Initiative
Action type: Collaborative project
Partnership: IMI (Art-185)
Countries involved: United Kingdom,United Kingdom,United Kingdom,Austria,Netherlands,United Kingdom,Belgium,Germany,Germany,Switzerland,United Kingdom,France,Finland,Germany,Belgium,United Kingdom
Call:  (IMI-JU-04-2011, 2011)
Start date: 2012-10-01
End date: 2017-06-30
Duration (months): 57.0
Total project cost (EUR): 26710806.0
EU funding (EUR): 9829638.0
Participants: 19
Project status: CLOSED

CHEM21 is a project that will develop a broad based portfolio of sustainable technologies for green chemical intermediate manufacture aimed at the pharmaceutical industry. Initially working with the EFPIA members the collaborators of CHEM21 will analyse a number of projects that are in development to decide which the priorities are for technology development. This analysis will also be used to update the literature of green technology based on updating previous papers. The technology being developed is divided into three work packages based on chemical catalysis and synthetic methods, biocatalysis and synthetic biology. The first effort will investigate the use of a range of catalysts with a main focus on replacing and applying catalysts based on common metals rather than the precious metal based catalysts that have limitations of sustainable supply. Use of continuous reactors and process intensification will also be addressed as well as fluorination chemistry. In biocatalysis a range of projects based on the needs identified by the chemical round table have been chosen including amide synthesis, stereo- and regio-specific hydroxylation of complex molecules as well as other redox reactions. Again process engineering and supercritical solvents will be developed as intensification methods. In the third part the development of the emerging field of synthetic biology will be addressed with the development of enzymatic chemical cascade pathways in fermentation strains with freedom to operate to produce targets of interest. Finally the outcomes of the efforts described will be incorporated into education and training efforts to produce the next generation of process chemists with a good understanding of green and sustainable metrics.

Keywords: green chemistry,sustainable chemistry,sustainability,synthetic biology,biocatalysis
Nanoelectronics for Safe, Fuel Efficient and Environment Friendly Automotive Solutions (SE2A)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Electronic Numerical Integrator and Computer
Action type: Collaborative project
Partnership: ENIAC (Art-185)
Countries involved: Greece,Greece,Hungary,Poland,Portugal,Romania,Netherlands,Netherlands,Netherlands,Sweden,Poland,Poland,Sweden
Call:  (JU-ENIAC-2008-1, 2008)
Start date: 2009-01-01
End date: 2011-12-01
Duration (months): 35.0
Total project cost (EUR): 21656394.0
EU funding (EUR): 3616618.0
Participants: 21
Project status: CLOSED

The societal need for a transport infrastructure based upon the availability of safe, fuel-efficient and environmental-friendly cars is clearly recognized by the European citizens and the European Commission. The fulfillment of this ambition is not to be taken for granted, as it requires the development of a host of automotive technologies, systems, software and tools. It is the objective of this project to create an integrated automotive control platform, enabled by breakthroughs in the areas of efficient fuel consumption, reduced CO2 emission and safe driving, to be achieved by the development of nanoelectronic components, subsystems and architectures. The project goals are in line with the targets defined in the ENIAC Strategic Research Agenda. The target parameters for 2011 are the following: • A reduction of the annual socio-economic costs caused by road accidents by 1-2% (of an estimated € 200B in Europe). • An improvement of fuel consumption efficiency by 5-10%. • A reduction of CO2 emission by 9% (in line with –30% reduction in 2020). The project work plan is subdivided in the following workpackages: • The definition of carriers and specifications • The design and development of optimized control systems. • The development of novel automotive process technologies and their integration into (sub)systems. • Design for reliability, test and yield • Prototyping and functional verification of the project objectives. • The dissemination of project results, and the release of the project deliverables. The project will be executed by a consortium incorporating the major European industrial, institutional and academic players in the field of R&D and innovation for automotive applications. It has 48 partners, located in 10 European companies. As such, it constitutes a new globally competitive team with the best qualifications for the job.

Keywords: automotive,fuel efficiency,co2 reduction,safety,relibility
Consumerizing Solid State Lighting (CSSL)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Electronic Numerical Integrator and Computer
Action type: Collaborative project
Partnership: ENIAC (Art-185)
Countries involved: Netherlands,Italy,United Kingdom,Belgium,Netherlands,Netherlands,Czechia,Italy,France,Spain,United Kingdom,Spain,France,France,United Kingdom,France,Belgium,Italy,Netherlands,Belgium,Belgium,France
Call:  (ENIAC-2009-1, 2009)
Start date: 2010-02-01
End date: 2013-01-01
Duration (months): 35.0
Total project cost (EUR): 27092103.0
EU funding (EUR): 4524384.0
Participants: 25
Project status: CLOSED

Light-emitting diode (LED) lamps are a rapidly-emerging technology to replace incandescent light bulbs that is gaining acceptance as an alternative to the compact fluorescent lamp. Commercial versions are already available, although there is frequently no single LED retrofit product that meets all consumer requirements. The ENIAC JU project CSSI aims to develop and demonstrate inexpensive smart solid-state light sources through advances in technology and application opportunities. The project will also work vertically across the entire European value chain to achieve substantial cost reductions.
Micro and Nano Technologies Based on Wide Band Gap Materials for Future Transmitting Receiving and Sensing Systems (MERCURE)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Electronic Numerical Integrator and Computer
Action type: Collaborative project
Partnership: ENIAC (Art-185)
Countries involved: France,Poland,Greece,Poland,Romania,Sweden,France,Germany
Call:  (ENIAC-2009-1, 2009)
Start date: 2010-02-01
End date: 2013-01-01
Duration (months): 35.0
Total project cost (EUR): 3297691.0
EU funding (EUR): 550714.0
Participants: 9
Project status: CLOSED

The ENIAC JU project MERCURE is developing advanced semiconductor materials to provide functionality not available before with silicon-based micro- or nanoelectronics. It will enable future ambient intelligence systems to achieve autonomous and self-reconfigurable operations with real-time and efficient self-optimisation of performance. Key applications will include the future wireless communications market which will expand to higher frequencies as new applications and frequency bands are allocated. This will require an always-connected, multi-standard, multi-service communications environment.
Secure Memories and Applications Related Technologies (SMART)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Electronic Numerical Integrator and Computer
Action type: Collaborative project
Partnership: ENIAC (Art-185)
Countries involved: France,Italy,Greece,France,France,Portugal,Germany,Germany,Portugal
Call:  (ENIAC-2009-1, 2009)
Start date: 2010-01-01
End date: 2013-12-01
Duration (months): 47.0
Total project cost (EUR): 19929984.0
EU funding (EUR): 2907467.0
Participants: 15
Project status: CLOSED

SMART Secure memories and applications-related technologies Growth in digital multimedia and in wired and wireless Internet- based services focuses attention on the need for protection of personal data and identification. Various electronic certification devices have been used – from magnetic-strip cards to increasingly sophisticated smart cards. Convergence of applications such as personal or private data, connectivity and multimedia requires high performance, large storage capacity, rapid data transfer and extended security against fraud. The ENIAC JU project SMART is developing a new generation of small, portable smart secure devices with enhanced performance.
Nanoelectronics for Mobile AAL Systems (MAS)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Electronic Numerical Integrator and Computer
Action type: Collaborative project
Partnership: ENIAC (Art-185)
Countries involved: Germany,Spain,Austria,Norway,Spain,Austria,Germany,Germany,Germany,France,Austria,Austria,Spain,Germany,Netherlands,Germany,Slovakia,Germany,Czechia,Czechia,United Kingdom,Netherlands
Call:  (ENIAC-2009-1, 2009)
Start date: 2010-04-01
End date: 2013-03-01
Duration (months): 35.0
Total project cost (EUR): 27386185.0
EU funding (EUR): 4573493.0
Participants: 30
Project status: CLOSED

The ENIAC JU project MAS is developing nanoelectronics components for applications in the field of health and wellness, and to create a development platform for the design of complete flexible, robust and safe mobile ambient-assisted-living systems. The project covers remote patient supervision using multi- parameter biosensors and telecommunications networks to improve the quality of the clinical environment as well as to encourage therapy at home. Implementation will require novel nanoelectronics technologies, interfaces, component designs and architectures for a common architectural approach.
RAS superfamily and the interactions with their effectors: functional specificity (RAS:EFFECTORS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2007-09-01
End date: 2009-08-31
Duration (months): 24.0
Total project cost (EUR): 30000.0
EU funding (EUR): 30000.0
Participants: 1
Project status: CLOSED

Ras genes code for small GTPases that act as GDP/GTP-regulated molecular switches. This exchange induces a conformational change that allows them to interact with their downstream effectors, and thus participate as central control elements in signal transduction. Mutated forms of the Ras oncoprotein are found in more than 30% of all human cancers, justifying the extensive research on them. Ras effectors have convergently developed a common subdomain in their unrelated overall structure for their interaction with Ras. Although detailed knowledge about the thermodynamics and dynamics of the interaction with Ras has accumulated, the molecular mechanism at atomic detail of effector activation and thus specificity is still elusive. Crystallographic, NMR, and other spectroscopic studies show that the flexibility of their so-called “switch regions” majorly contributes to the adaptability of the Ras proteins to their various partners, including disorder-to-order transitions upon binding to their partners, and “structural polymorphism” in their different complexes and in the unbound forms. This incorporates another degree of difficulty on the understanding of the Ras:effector association. Although some studies have been previously carried out in order to rationalize the specificity of the Ras proteins towards their different effectors, they have been based only in the availability of Ras:effector crystal structures and taking a rather static point of view. In this work we intend to extend this to a large-scale bioinformatics and computational study, including driven-docking of Ras proteins and their effectors for which no complex structure is available but biological data supports complex formation. In a further step, Molecular Dynamics simulations both on the unbound partners and on their complexes will yield information accounting both for the binding affinity and for the intrinsic plasticity crucial in the recognition and regulation of Ras pathways

Keywords: health sciences,computational biology,structural biology,computational chemistry,biological sciences
Researchers as Guides to Glory of Ancient Europe (REGGAE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Bulgaria,Bulgaria,Bulgaria,Bulgaria
Call:  (FP7-PEOPLE-2007-5-1-1-NIGHT, 2007)
Start date: 2007-06-01
End date: 2007-11-30
Duration (months): 6.0
Total project cost (EUR): 93248.0
EU funding (EUR): 85000.0
Participants: 6
Project status: CLOSED

The project REGGAE sets as its main goal to enhance public recognition of researchers and their role in society and to encourage young people in Bulgaria to embark on scientific career. For achieving its main goal, the following project objectives are: -to disclose to the public the hidden sides of life and work of researchers, and show them as professionals and ordinary people; -to raise the public awareness on the contribution of researchers to society, to its progress and development; -to highlight the EU emphasis on its researchers and the opportunities for them in the large European labour market; -to make science and the respective career attractive for young people. The project REGGAE will aim to provide various opportunities to Bulgarians to interact and have fun with researchers. The project activities will take place in several Bulgarian cities, where researchers will guide the public into the secrets of archaeology and history, and the technology supporting them, will interact with young people in the Atelier of young talents, and enjoy the public with life performances, jokes on researchers, experiments and joined games. The project aims to prepare high visible activities designed in accordance with the target audience. Most of them are focused on facilitating the dialogue between researchers and the public at large, and especially providing young people with opportunity to interact with researchers in a not traditional environment, and to learn more on scientific and technology issues of the day. For the first time an accent will be put also on the visualisation of the researchers through specific tasks as presentations, multimedia, photographs which will ameliorate public acceptance of the “normal” image of the researchers and will facilitate the interaction with the media.

Keywords: fun with researchers,society
Researchers Night 2007 in the Czech Republic (RN07CZECHREP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Czechia,Czechia,Czechia,Czechia
Call:  (FP7-PEOPLE-2007-5-1-1-NIGHT, 2007)
Start date: 2007-06-01
End date: 2007-11-30
Duration (months): 6.0
Total project cost (EUR): 83902.0
EU funding (EUR): 63148.0
Participants: 5
Project status: CLOSED

The purpose of this project is to plan, prepare and implement Researcher’s Night in three major cities and twenty three other locations throughout the Czech Republic. This project aims to: present researchers as “normal” people to the general public, show research professions as interesting and fun thus making them appealing to young people, promote science in elementary and secondary schools, and demonstrate how Europe supports its researchers and the sciences. Eliminating gaps and building bridges between researchers and the general public is also a focus of this project. The Project is based on a partnership made up of five organisations. The participants have a wealth of experience with 5th and 6th Framework Programmes and with activities promoting researchers and science. Some of the partners also took part in Researcher’s Night 2006 in the Czech Republic. When planning the programme and the individual activities, emphasis was placed on interactivity and entertainment. Hands-on practical experiments, scientific demonstrations, guided tours through different research workplaces, competitions, and games are the main types of attractions prepared for the public. Researchers will be also presented in unexpected professions such as musicians, photographers, or writers and this will help to change the public perception of researchers as “mad” people closed up in their secretive, distant labs. The compulsory drawing competition and the EU stand will also be implemented in the three major locations. European support of research and development will be also demonstrated and researchers who have benefited from the support will give testimony in person. All in all, Researcher’s Night 2007 is a great opportunity for the public and the researchers to meet face to face and for proving that science plays an important part in our lives and that it can be also fun.

Keywords: researchers,science,people,public,youth,partnership,career,embark,fun,competition,quiz,hands-on,experiments,interactive,entertaining,tours,labs,demonstration
AlleGria Oltre la RicercA (AGORA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Italy
Call:  (FP7-PEOPLE-2007-5-1-1-NIGHT, 2007)
Start date: 2007-06-01
End date: 2007-11-30
Duration (months): 6.0
Total project cost (EUR): 343000.0
EU funding (EUR): 207000.0
Participants: 1
Project status: CLOSED

AGORA’ project is a continuation, a deepening and an enlargement of the very successful COME IN project which took part to the Researchers’ Night 2006 FP6 programme. Based on the success of the 2006 edition (more than 4.000 participants, twice more than anticipated, - http://www.infn.it/nottedellaricerca/ for details) the 2007 edition intends to re-propose all the successful activities held in 2006 (as visits to the Institutes; activities for children; Saperi/Sapori festival; researchers’ hobby exhibit; concert with researchers as artists) and to realize new activities meant to bring the total number of potential participants to more than 10.000 (could even be double). In order to do this, new activities will be performed outside the Research Institutes – in the main squares, in cinemas, restaurants, parks, streets, libraries, etc of Castelli Romani towns, completing the activities held in the research Institutes. This enlargement is going to “close the circle”, so reflecting better the spirit of Researchers’ Night objectives: public comes into researchers’ homes and researchers go to public places. The multi-facets of researchers in society will be explored and exploited in a more complete way. AGORA’ addressed to the general public, with well-identified parallel and correlated activities, dedicated to the very young children, to teenagers and for el/older public. The researchers from Laboratori Nazionali di Frascati – the biggest one of the INFN Institute, the organizing Institute, will actively participate, together with researchers from Institutes in the Frascati area, as ENEA, ESRIN, CNR and INAF, and of Roman Universities. A strong contribution will also come from territorial/regional administrations, INFN administration, from various libraries, cinemas, radio-stations and editing houses, as well as and from local producers strongly involved in the AGORA’ activities.

Keywords: people,reserach,education