Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Teaming conductivity and chemical functionality in metal-organic frameworks for zinc‑ion batteries (Z-ION)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Czechia,Greece
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-01-01
End date: 2025-02-28
Duration (months): 26.0
Total project cost (EUR): 166832.91
EU funding (EUR): 166832.91
Participants: 2
Project status: CLOSED

Zinc-ion batteries (ZIBs) are among the most promising electrochemical energy storage (EES) technologies that could meet the future demand for green and safe storage of electric power, which is vital for a low carbon and fossil-fuel independent civilization. However, the low cost, Earth-abundance and superior safety/stability of zinc (Zn) in comparison to lithium-ion batteries, comes with formidable challenges, such as slow zinc ion migration and dendrite growth, limiting their charging/discharging time and life-span. Recent advances have expanded the design toolbox of metal organic frameworks (MOFs) and of tailored graphene derivatives – the core expertise of the applicant and of the host institution, respectively– which could drive the developments towards the next generation of ZIBs. The Z-ION project comes to meet the fundamental need for decarbonisation enabling safe, sustainable and low-cost batteries via the exploration of 3D and 2D conductive MOFs (CMOFs) and hybrids thereof with tailored graphene derivatives as hosts for Zn, which have so far remained largely unexplored in ZIBs. The conductivity and open framework of these materials, in comparison to the present insulating and low porosity cathodes, can boost Zn ion migration. Functionalization of both materials with chemical groups suitable for Zn coordination can streamline a homogeneous and dendrite-free deposition of metallic Zn at the anode through directed nucleation in their frameworks and at coordination sites. Importantly, tailored graphene derivatives with dense out-of-plane functionalities can facilitate the formation of covalent hybrids with CMOFs, ascribing hierarchical porosity and conductive bridges between the CMOF particles or sheets. The Z-ION project will thus offer indispensable knowledge for the advancement of low-cost, sustainable, and safe ZIBs, which also offer one of the highest volumetric energy densities, necessary for storing a lot of energy in small-sized batteries.

Keywords: metal organic frameworks,conductive,graphene,covalent hybrids,zinc ion batteries,sustainable
Universal GPCR Activity Sensor for Next Generation Drug Discovery (UniSens)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Germany,Spain,Czechia,France,Netherlands,Switzerland
Call: EIC Pathfinder Open (HORIZON-EIC-2023-PATHFINDEROPEN-01, 2023)
Start date: 2023-11-01
End date: 2027-10-31
Duration (months): 48.0
Total project cost (EUR): 2965384.75
EU funding (EUR): 2965384.75
Participants: 8
Project status: SIGNED

This project by a consortium of academic labs and small biotech companies concerns a new key innovation for the development of drugs targeting G protein-coupled receptors (GPCRs). GPCRs are the most important class of therapeutic targets, both for current drugs and those under development, covering about a third of the €1.2 trillion pharmaceutical market. Recent research has revealed that GPCRs do not function as simple on/off switches but instead can adopt multiple conformations leading to complex textures of downstream effects. Functionally selective drugs modulate the GPCR structure to stimulate certain downstream pathways over others. In the search for this next generation of better drugs, the pharmaceutical industry currently employs multiple (10+) distinct GPCR assays, performed in non-identical cellular contexts, and misleading readouts from this approach contribute significantly to costly drug failure. Here we propose a radically new single-assay technology platform that will enable detection and functional classification of drug candidates with superior confidence compared to today's approaches. Its unique design supports streamlined drug discovery from the test tube to the native disease-relevant cell, as well as the capacity to efficiently harness artificial intelligence (AI) in the design of better drugs. The technology is based upon highly informative fluorescent sensor reagents that react to different receptor conformations with subtle, flexible changes in their structure. In this Pathfinder project, our main objective is to demonstrate that the conformational fingerprints generated by these sensors correlate to specific cellular signalling profiles, i.e. GPCR activity states (proof of principle). We believe that the UniSens platform will become the standard tool for early drug development and could be a game-changer in the search for safer, more effective drugs.

Keywords: gpcr,biased agonism,biosensor,machine learning
EOSC-ENTRUST: A European Network of TRUSTed research environments (EOSC-ENTRUST)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: EOSC ecosystem
Action type: Research and Innovation actions
Partnership: EOSC (co-programmed)
Countries involved: Germany,Finland,Spain,Netherlands,Czechia,Denmark,Portugal,Estonia,Luxembourg,Slovenia,France,Belgium,Norway,Hungary,Greece,Sweden,United Kingdom
Call: Trusted environments for sensitive data management in EOSC (HORIZON-INFRA-2023-EOSC-01, 2023)
Start date: 2024-03-01
End date: 2027-02-28
Duration (months): 36.0
Total project cost (EUR): 4303452.61
EU funding (EUR): 4218809.75
Participants: 34
Project status: SIGNED

The mission of EOSC-ENTRUST is to create a European network of trusted research environments for sensitive data and to drive European interoperability by joint development of a common blueprint for federated data access and analysis. Countries and institutions have made significant investments in secure and trusted data environments to meet the need for research and policy-driven analysis of sensitive datasets such as people's health and socio-economic status, the habitats of vulnerable species and geo-spatial locations of protected sites. There are now a large number of such secure environments in operation - linked to national centres, individual organisations or specific research communities. This fragmented landscape poses challenges for both users and providers: researchers are faced with a large number of different systems and access procedures; providers need to manage federated access across multiple, potentially incompatible, technology and governance frameworks. EOSC-ENTRUST brings together providers of operational Trusted Research Environments from 15 European countries with a shared goal to implement, validate and promote their capabilities through a common European framework using shared standards and common legal, operational and technical language. This blueprint for interoperability is anchored in the EOSC Interoperability Framework spanning the four dimensions of Legal, Organisational, Technical and Semantic interoperability. EOSC-ENTRUST has identified four driver projects covering Genomics, Clinical trials, Social science, and public-private partnerships to benchmark capabilities, inform blueprint design and demonstrate secure data analysis using federated workflows. Targeted outreach activities will expand this open network with further providers and develop policy papers and guidelines for the full range of stakeholders to create a long-term operational TRE framework within the European Open Science Cloud.

Keywords: blueprint,fair workflows,eosc,ehds,tre providers,european network,sensitive data management,federated data access
Production of superior meat analogues by bridging the benefits of plant proteins and mycelium protein biomass produced from circular substrates (PLANTOMYC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: Sweden,United Kingdom,Netherlands,Denmark,Serbia,Spain,Switzerland
Call: New healthy and sustainable food products and processes (HORIZON-CL6-2024-FARM2FORK-01, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 4618367.5
EU funding (EUR): 4618367.5
Participants: 12
Project status: SIGNED

PLANTOMYC is a transformative initiative aiming to reshape the landscape of the alternative protein sector. It aims to bridge the versatile benefits of plant-based proteins with the functional and organoleptic (taste, aroma, texture) advantages of mycelial protein biomass (MPB) and develop innovative minimally processed hybrid meat analogues that are both healthy, and tasty. The project promotes sustainability by upcycling underutilized circular substrates such as starch rich pea protein by-product, and brewers spent grains to produce MPB by submerged fermentation (SmF) and solid-state fermentation (SSF), respectively. Envisioning a near-zero waste process design, PLANTOMYC proposes converting the broth from SmF into a Gamma-aminobutyric acid (GABA) enriched beverage and / or a flavorful bouillon. Adopting a multi-actor approach, the project addresses challenges related to consumer preferences, technological scaling, and regulatory requirements. Notably, the impact of PLANTOMYC’s product prototypes on nutritional, functional (gut health & metabolic syndrome), techno-functional, and sensory properties will be assessed thoroughly. Moreover, to advance PLANTOMYC’s TRL, we perform a comprehensive impact assessment for the adoption of these products, utilizing our consortium’s industrial end-users. PLANTOMYC will significantly increase the competitiveness of European alternative protein initiatives. It will accelerate the sector by offering an open-access knowledge platform, introducing new production concepts for hybrid meat analogues, increasing resource independence and efficiency, providing new market opportunities for industrial partners like Millow, BRØL, and Lantmännen, increasing the affordability of alternative proteins, and reducing the environmental footprint of protein production

Keywords: mycelium protein biomass,hybrid meat analogues,solid state fermentation,hybrid product design,pea protein starch by product
High energy density and long cycle life near-neutral Zn-air rechargeable batteries using polyoxometalates nanoclusters as homogenous catalysts (POMZAB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: CLOSED

Even though Li-ion batteries have dominated the market so far, they lack the desired properties for large scale electric grids or electric vehicles. Besides, there are some concerns regarding the safety and raw-materials availability in the future. In this context, Zn-air batteries emerge as the most promising candidates to be the post-lithium technology for their lower weight and volume, and inherently safety. However, their cycle life is still below the required standards. Therefore, the goal of this proposal is to develop efficient electrically rechargeable Zn-air batteries with high energy density and cycling stability. To achieve this, near neutral electrolytes will be used instead of traditional highly alkaline solution employed in non-rechargeable devices. The latter leads to significant improvements in Zn anode cyclability increasing battery life. However, to fully exploit the potential of this technology, bifunctional catalytic materials specifically design to operate in this pH conditions are necessary and still missing. This project seeks to address this matter using metal oxide nanoclusters, known as polyoxometalates (POM), as homogenous bifunctional catalyst to promote both oxygen evolution and reduction reactions. These materials have outstanding electrochemical properties including an excellent reversibility, which makes them ideal for rechargeable energy storage devices. This research plan will investigate the electrocatalytic activity of various POMs in near neutral electrolytes using several electrochemical techniques. These will be later test in lab-scale Zn-air batteries to assess the performance of POMs as bifunctional catalyst in real operating conditions. The combination of near-neutral electrolytes and POM-based air cathodes is expected to allow fabrication of ZAB devices with increased cycle life, specific and volumetric energy density and power density. These improvements will consolidate ZAB secondary batteries as a post-lithium technology

Keywords: zinc polyoxometalates electrocatalysis bifunctional air cathode energy storage
Twinning to skyrocket scientific excellence towards individual radiosensitivity prediction by raising the bar in knowledge transfer, networking, and technological innovation in radiobiology (RadExIORSBoost)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Life Sciences
Countries involved: Serbia,Germany,Austria,Slovenia,United Kingdom
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 1223641.27
EU funding (EUR): 1223641.27
Participants: 5
Project status: SIGNED

Prostate cancer patients receiving radiotherapy (RT) may develop radiation-induced side effects, which significantly impact quality of life. One of the main challenges in radiobiology is to predict individual patient's normal tissue radiosensitivity to tailor personalized RT. Although the Institute for Oncology and Radiology of Serbia (IORS) is a highly specialized health, scientific, and educational institution it is necessary to develop a strategic action plan and sustainable knowledge transfer networking with top-class leading European institutions. Through the 6 Specific Objectives, RadExIORSBoost project aims to develop and implement institutional Scientific Strategy on radiobiology, to investigate individual radiosensitivity by transcriptome profiling, radiation-induced lymphocyte apoptosis, and measurement of DNA damage levels, to design a high-quality clinical study, and to raise the research capacity of IORS and partner institutions through 5 international workshops, 8 short-term visits, and 6 trainings. RadExIORSBoost project aims to strengthen the administrative and research management skills of IORS. RadExIORSBoost project realization will increase the scientific excellence of IORS to approach high-ranking partner institutions, Medical Faculty Mannheim, Heidelberg University (UHEI), Germany, the University of Leicester (ULEIC), United Kingdom, Medical University of Vienna, Center for Cancer Research, (MUW) Austria, and the Institute of Oncology Ljubljana (IOL) from Slovenia. Artificial intelligence-based models, such as machine learning may give directions towards the clinical application of peripheral blood mononuclear cell transcriptome, and list potential biomarkers predicting radiotoxicity, not only in cancer patients, but also in healthy individuals at risk. RadExIORSBoost project may blaze the trail for technological innovations in modern radiation oncology to significantly reduce the side effects of RT and its harmful effects on the environment.

Keywords: radiobiology,individual radiosensitivity,prostate cancer radiotherapy,increase of iors scientific excellence,strengthening of iors administrative capacity
Regulation of DNA replication origins during normal development and tumorigenesis (HS_MSCA_2021)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-02, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 166278.72
EU funding (EUR): 166278.72
Participants: 1
Project status: SIGNED

The development of the human body starts from a single cell, fertilized egg, which divides about ten trillion times to form an adult human. During every cell division, the genome is duplicated with great accuracy by DNA replication and distributed with one copy to each of the two daughter cells. Understanding how the cell regulates DNA replication remains one of the most fundamental questions in biomedicine, because up to two-thirds of all cancers are caused by accumulation of errors during DNA replication. Pre-replicative complexes (pre-RCs) serve as essential precursors for DNA replication and their accurate levels are critical to alleviate genome instability associated with severe diseases, including cancer. Indeed, the overexpression of pre-RCs has been reported at early stages of variety of cancers making them an attractive target for cancer therapy. On the other hand, programmed genetic instability is part of the normal mammalian development, including heart cells. The aim of this project is to map differences in the mechanisms that regulate pathological and physiological genetic instability, an area that remains largely unexplored. We will identify signaling pathways responsible for optimal levels of pre-RCs and understand their contribution to genome instability during oncogene-induced tumorigenesis and programmed polyploidy during cardiomyocytes maturation in normal mammalian development. By combining physiologically relevant mammalian cellular models with state-of-the-art CRISPR-Cas9 genome editing, quantitative cell biology, genomics, and proteomics approaches we will address mechanism regulating accurate pre-RC formation and its role in physiological and oncogenic cellular transformation. Our findings will lay the foundations for the development of new anticancer drug targets and thereby expand therapeutic strategies for treatment of cancer associated with misregulated pre-RC levels and poor prognosis.

Keywords: dna replication,cell cycle,genome stability,cancer,cardiomyogenesis
Surface-enhanced Raman spectroscopy in liquid biopsy for breast cancer (SIREN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Italy,Singapore
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 3
Project status: SIGNED

Despite current large-scale mammography screening programmes, breast cancer is still the leading cause of cancer death in women in the vast majority of countries. It is recognizable that cancer deaths could be prevented through earlier diagnosis and adequate treatment. Therefore, new vigilant diagnostic tools that could provide an earlier diagnostic should be developed. The progress regarding sensitive, robust, fast, and cost-effective biosensors is a very active research field. Surface-enhanced Raman scattering (SERS) spectroscopy is a powerful technique for ultrasensitive label-free analysis of chemical and biological samples with wide applicability, vastly demonstrated for cancer. Nevertheless, translation of SERS to the clinics and industry is limited due to the lack of reproducible substrates and automation routines to analyze complex spectra. Liquid biopsy is the most commonly used practice for clinical preliminary disease screening. Some groups have already shown noteworthy work addressing the potential of SERS in blood plasma and urine, making it suitable for rapid and minimally invasive cancer diagnosis. SERS can be applied to sense subtle changes in composition and structure of biomolecules in plasma/urine from cancer subjects. Allied to this, discriminant analysis models (DAM) have been applied to SERS. These studies demonstrate that a powerful diagnostic system can be built for cancer screening with very high specificity and sensitivity.The main objective of SIREN is the development of a liquid biopsy test on which highly sensitive solid SERS substrates will detect changes in biomolecular profile between cancer and no cancer samples. Blood plasma and serum, and urine will be used in a label-free detection. Combining with new developed clinical decision-support systems based on SERS spectral analysis the project will provide a classification system for early diagnosis progression and breast cancer in patients.

Keywords: sers,nanomaterials,breast cancer,liquid biopsy