Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Reducing Non-Human Primates in Non-Clinical Safety Assessment: The European Initiative on Minipig and Micropig Models (NHPig)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Innovative Health Initiative
Action type: Research and Innovation actions
Partnership: IHI (JU-JTI)
Countries involved: Germany,Belgium,Austria,Denmark,Italy,France,Hungary,Sweden,Czechia,Switzerland,United States,United Kingdom
Call: Expanding translational knowledge in minipigs: a path to reduce and replace non-human primates in non-clinical safety assessment (HORIZON-JU-IHI-2023-04-two-stage, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 17522696.5
EU funding (EUR): 8499555.5
Participants: 32
Project status: SIGNED

NHPig is an Innovative Health Initiative (IHI) project based on the public-private partnership of the European Union and Europe’s health industries. Its objective is to expand, share and implement biological knowledge of mini-/micropig models with the aim to reduce non-human primates (NHPs) in non-clinical safety studies. The transnational consortium includes experts in porcine medical models, veterinary pathology, computational animal science, non-clinical science, OMICs profiling, new approach methods (NAMs), as well as bioinformatics and artificial intelligence. NHPig will i) characterise humanised minipigs, micropigs and tailored disease models, including systematic biobanking, multi-OMICs profiling, and state-of-the-art imaging modalities; ii) develop, validate and implement biosensors, medical devices, and ‘intelligent’ animal housing for automated data collection and analysis in minipig safety studies; iii) fill significant knowledge gaps in the (patho)physiology of the porcine immune system; iv) validate known toxicity and efficacy biomarkers and discover novel biomarker candidates for non-clinical safety assessment; v) overcome the shortage of laboratory tools and reagents, such as validated antibodies; vi) gain experience in using mini-/micropigs for safety testing of biologicals and new therapeutic modalities; vii) Investigate in vitro to in vivo extrapolation of liver and kidney toxicity in pigs and NHP/humans to provide a comparative link to human new approach methodologies (NAMs); and viii) provide a publicly available database and IT platform for compiling, integrating and analysing existing data in NHPs/humans with data in mini-/micropig models (existing data and data generated within the NHPig programme). The establishment of a regulatory advisory board and an ethics- and animal welfare advisory board will expedite regulatory interactions and ensure compliance with the 3R principles. NHPig will generate the scientific basis for de-selection of NHPs in non-clinical safety assessment, which is an ethical requirement and also imperative according to EU legislation.

Keywords: minipig model,micropig,humanized pig,multi omics analysis,novel biomarkers,3r,translatability between species,in vitro in vivo correlation
Modulating feeding behavior in obesity: from brain lesions to non-invasive brain stimulation targets (FoodConnect)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Portugal
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-07-01
End date: 2026-12-31
Duration (months): 30.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Altered feeding behaviors impair physical and psychosocial health and may lead to overweight or obesity. Obesity is a major global health challenge but current treatments are either ineffective in the long-term or carry important risks. Hence, novel therapeutic approaches are needed. The main ERC StG aims to explore the neural basis of eating patterns by exploring post-ingestive reinforcement of food-seeking behavior. In that context, we are studying the contribution of gut-brain communication towards activity in brain circuits controlling feeding behavior. Another strategy to clarify the neuroanatomy and neural correlates underlying dysfunctional human behaviors has been to study their occurrence when associated with a brain insult. We have used this approach for neuropsychiatric disorders, and believe it may also be used for feeding behavior. Indeed, changes in weight regulation concurrent with brain lesions have been described, raising the question of whether such lesions follow a particular distribution in the brain or impact specific functional networks. Several neuroimaging analysis methods can be used to explore if specific brain areas and/or connectivity networks are associated with specific lesional syndromes. In addition, these methods have also been proposed to offer the opportunity for development of novel strategies for therapeutic brain stimulation, such as transcranial magnetic stimulation (TMS). In this project, we aim to identify TMS targets that potentially modulate feeding behavior, supported by lesion topography and/or connectivity networks involving lesions associated with changes in feeding behavior and weight regulation. We will then conduct a TMS protocol targeting the identified regions to modulate feeding behavior in patients with obesity. We are convinced that FoodConnect will contribute to the understanding of the pathophysiology of obesity, and the development of innovative therapeutic approaches for such a highly prevalent and socially impactful condition.
From Keyboard Warrior to Digital Army: Mapping Far-Right Networked Publics (MAFNET)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 203464.32
EU funding (EUR): 203464.32
Participants: 2
Project status: CLOSED

The question driving the project From Keyboard Warrior to Digital Army: Mapping Far-Right Networked Publics (MAFNET) focuses on how far-right online communities recruit, radicalize, and mobilize in response to policy regulations on extremism and terrorism by technology companies. In this project, I will study the effects of tech company policy responses on far-right users by utilizing a comparative focus across North America, Europe, and India. Studying across these contexts will illustrate the differing ways in which far-right users adapt and respond to policies aimed to hinder their activity online. Although tech companies operate globally, policy teams develop local approaches for addressing extremist content on their platforms, often guided by national and regional legal frameworks. This project utilizes an innovative research design in determining the reciprocal relationship between how far-right users act on platforms (shifting from individual to collective action) and the ways in which tech company policies react to far-right activity on their platforms, thus shaping far-right adaptation techniques online. I combine a digital ethnographic approach towards studying online behaviour of far-right users with qualitative interviews and focus groups of tech company policy employees. This project will elucidate the processes of far-right online community building, contributing to scholarship on digital cultures, media governance and regulation, and social movements. It will provide insight for policymakers, practitioners, and tech companies on countering radicalization and recruitment into the far-right, as well as effective approaches to challenging far-right propaganda.

Keywords: far right extremism platform governance
The Ethics of Synthetic Data in the Age of Machine Learning and AI (SYNDATA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: United Kingdom
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1248460.0
EU funding (EUR): 1248460.0
Participants: 1
Project status: SIGNED

SYNDATA develops a novel approach to understanding the ethical consequences of synthetic data for contemporary societies. Machine learning algorithms and AI models such as Gemini and GPT-4 are increasingly used to generate data (called ‘synthetic data’), which is in turn used to train other algorithmic models. This is leading to transformations in social and political life, because synthetic data embody a promise to address an array of ethical challenges associated with AI, such as the lack of ethnic diversity and gender representation in large training datasets, in addition to issues of privacy and confidentiality in sensitive datasets. In short, if some data cannot be collected in the real world, it can be generated via algorithms. This is particularly relevant in societal domains – such as healthcare, finance, and government – where an ethical question in the use of sensitive personal data is common. While there is a substantive literature outlining the various effects of data and algorithms on society, the area of synthetic data remains both under-researched and under-theorised. As such, SYNDATA will pioneer the first large-scale, systematic social science study of synthetic data. By examining the three pressing issues of generativity, representation, and resistance, the project will take seriously the ways that synthetic data are generated whilst also transforming how contemporary algorithms and AI models are trained and deployed in society. In order to do this, the project will conduct both archival research into the historical antecedents of synthetic data as well as path-defining studies of different areas where synthetic data is currently being generated and deployed as a way to train algorithmic systems: biometrics and facial recognition as well as weapons ammunition detection. SYNDATA will provide cutting-edge social science knowledge on how the emergence of synthetic data is transforming the relationships between data, AI, and ethics in society.

Keywords: ai,algorithms,bias,data,ethics,synthetic,society,technology
European Training Network on Post-Digital Computing + (POSTDIGITAL+) (POSTDIGITAL Plus)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Switzerland,France,United Kingdom,Belgium,Germany
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-02-01
End date: 2029-01-31
Duration (months): 48.0
Total project cost (EUR): 4134929.14
EU funding (EUR): 3681576.0
Participants: 15
Project status: SIGNED

The future economic growth in Europe requires engineers and researchers capable to design, develop and implement new information technologies to support explosive data-driven transformation of economy, public and government activities. The analysis of this data demands a massive increase in processing power and communication bandwidth. Current information, computing and processing technologies strongly rely on the classical digital approaches and architectures developed by von Neumann. However, technological progress rates of digital technologies are flattening out and are about to hit their ultimate, physical ceilings (“end of Moore’s law”). This growing gap between what is demanded and what can be delivered becomes exacerbated by the increasingly inacceptable energy consumption of the global ICT infrastructure, whose relevance is amplified by the pressing and approaching climate crisis. In this situation, both academic and industrial ICT research has started to investigate and invest in so-called “unconventional”, nature-inspired approaches to computing which radically depart from the classical digital paradigm. European Doctoral Network on POSTDIGITAL Plus brings together internationally leading teams from academia, research centres and leaders of industry, including IBM, Thales, Hewlett Packard Enterprise Belgium and three regarded start-ups NcodiN, Akhetronics and VLC Photonics in the field of optical computing to train a cohort of 15 doctoral candidates in the inter-disciplinary fields of emerging disruptive neuromorphic computational technologies and their applications. POST-DIGITAL Plus has the ambition and the vision to create a new generation of scientific and industrial leaders that will greatly contribute to strengthening Europe’s human resources and industry competitiveness in future digital and post digital economy and technology.

Keywords: analog computing paradigms,non algorithmic computing,novel electronic and photonic technologies,reservoir computing
GRIP on MASH: Global Research Initiative for Patient Screening on MASH (GRIPonMASH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Innovative Health Initiative
Action type: Research and Innovation actions
Partnership: IHI (JU-JTI)
Countries involved: Netherlands,Belgium,Italy,Romania,Greece,Czechia,Denmark,France,Sweden,United Kingdom,Spain,Portugal,Switzerland,Germany
Call: Screening platform and biomarkers for prediction and prevention of diseases of unmet public health need (HORIZON-JU-IHI-2022-03-single-stage, 2022)
Start date: 2023-12-01
End date: 2027-11-30
Duration (months): 48.0
Total project cost (EUR): 26164763.25
EU funding (EUR): 14035277.25
Participants: 35
Project status: SIGNED

GRIP on MASH will address the unmet public health need of reducing disease burden and comorbidities associated with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD). Together with seven medical technology, pharmaceutical and biotechnology companies, we will devise a sustainable and scalable GRIP on MASH Platform that will enable access to at-risk patients developing or having MASLD through the early detection of this condition at the primary care level. This Platform will allow A) the early detection of patients with MASLD: distributed in 12 European Centers of Excellence (CoEs), 10,000 patients at high risk of MASLD - defined as patients with type-2 diabetes mellitus, metabolic syndrome, obesity or arterial hypertension - will be screened and characterized; B) better patients’ stratification: the Platform will comprise artificial intelligence-based decision support tools that will make use of existing and novel biomarkers/biomarker combinations. Their predictive accuracy will be tested at the primary care level; there we will perform multi-OMICs analysis (proteomics, lipidomics, metabolomics, genomics, metagenomics and fluxomics) in fasted blood samples and we will explore imaging biomarkers/organ-on-a-chip to find future non-invasive diagnostic alternatives for the current standard (liver biopsies); and C) personalized lifestyle advice, by exploring evidence-based lifestyle features and the effect of nutritional recommendations: among the cohorts at the CoEs, we will use validated questionnaires to assess physical activity, diet, sleep, smoking, alcohol consumption, and perception of stress. Integrating patients’ perspectives with the participation of two patient organizations, the trustworthiness and sustainability of our GRIP on MASH Platform will be assessed by investigating potential economic, ethical and regulatory barriers to its future adoption. GRIP on MASH will change healthcare practice in MASLD and reduce the disease burden for patients.

Keywords: risk factors
Accelerating ERA by Sharing Unique Talents for healThy Life and Environment (ERA_SHUTTLE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Coordination and support actions
Countries involved: Croatia,Poland,Malta,Germany,Italy,Netherlands,Romania,Slovenia
Call: Fostering balanced brain circulation – ERA Talents (HORIZON-WIDERA-2022-TALENTS-03, 2022)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 3093030.0
EU funding (EUR): 3093030.0
Participants: 18
Project status: SIGNED

ERA_SHUTLLE is creating a cross-sectoral framework for collaboration and possibilities for talents from different backgrounds to address contemporary health and environmental challenges and produce innovative solutions for the benefit of society. The ERA_SHUTTLE's main goal is to foster R&I capacity in the ERA to benefit the participating widening countries Poland, Croatia, and Malta. This will be accomplished by bolstering R&I support capacities, boosting cross-sectoral collaboration, and implementing cross-sectoral knowledge valorisation and talent circulation experiments while boosting the attractiveness of regional R&I ecosystems. This action is designed by leading research universities from widening countries with underdeveloped RI landscapes and strong non-academic institutions and associations from non-widening countries such as Steinbeis, CERIC-ERIC and ASTP. The ERA_SHUTTLE brings universities, non-academic, and private organisations together to eliminate existing barriers and work toward a common objective by offering training and secondment opportunities that celebrate diversity. Project partners will develop their core capacities and benefit from ERA knowledge and expertise exchange. The project supports industry-research needs by cross-fertilizing ideas to address hurdles and low levels of research valorisation. Following the European Industrial Strategy and the European Skills Agenda, ERA_SHUTTLE will help R&I talents from Widening countries deepen their capacity and broaden their skill set to improve research, knowledge valorisation, and cross-sectoral collaboration. Through specific objectives, project will: identify research institutions' strengths and weaknesses and increase access, integration, and use of research equipment and knowledge, improve research conditions, employability, and career possibilities to attract and retain top research and innovation talent in expanding countries and implement cross-sectoral talent mobilities.

Keywords: research and innovation support staff,research and innovation ecosystems in widening countries,randi in health and environment,capacity building research support
Mathematics of Scattering Amplitudes (MaScAmp)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Ireland,United Kingdom,Sweden
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-06-01
End date: 2031-05-31
Duration (months): 72.0
Total project cost (EUR): 9986500.0
EU funding (EUR): 9986500.0
Participants: 4
Project status: SIGNED

MaScAmp proposes a new paradigm for fundamental interactions in physics in the form of a unified mathematical approach to scattering amplitudes. The project brings together a multidisciplinary team with expertise in pure mathematics and theoretical physics who will develop a set of novel and efficient algorithmic methods with applications in mathematics, particle physics and gravity. Discoveries in many areas of fundamental physics depend upon a detailed understanding of the scattering of particles. Modern experiments, such as particle colliders and gravitational-wave detectors, demand high-precision theoretical computations to make new discoveries. These are deduced from physical models by a highly labour-intensive process relying on the calculation of scattering amplitudes, which assign probabilities to particle interactions. Despite a tremendous worldwide effort over many decades, the methods used to compute increasingly complex scattering amplitudes remain disparate and fragmented. The work of the PIs in distinct domains suggests unexpected symmetries and universal rules obeyed by scattering amplitudes in different-looking areas of physics. This calls for a radically new way of studying scattering amplitudes. MaScAmp will create a unified framework for the calculation of general scattering amplitudes by building upon the latest research in mathematics, notably in algebraic geometry and number theory. As a result, MaScAmp will overcome longstanding computational bottlenecks, push the boundaries of numerous areas of theoretical physics, such as quantum field theory, gravity and string theory, and inspire new mathematical research. A widely applicable computer software implementation will enable physicists to make previously inaccessible predictions for present and future experiments. A project of MaScAmp’s scope and ambition is only achievable by combining the unique expertise of the PIs in complementary areas of mathematics and physics.

Keywords: scattering amplitudes,feynman integrals,iterated integrals,periods,motivic galois theory,string theory,symbolic integration,moduli spaces,modular forms,polylogarithms
Superhydrophobic membranes for clean water production (SuperClean)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Greece,Germany,Belgium,Netherlands
Call: EIC Transition Open 2022 (HORIZON-EIC-2022-TRANSITION-01, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 2497750.0
EU funding (EUR): 2497750.0
Participants: 6
Project status: SIGNED

Our world faces an urgent need for a greener industry with reduced water consumption and zero pollution, alleviating water scarcity problems. Membrane distillation (MD) is being explored for production of clean water from industrial waste streams in the steel, textile, food and other industries. Several challenges need to be overcome to achieve a full commercial market breakthrough for MD: Membrane wetting, scaling, and fouling. We plan to accept the challenges by using superhydrophobic membranes. Such membranes are also useful in oil-water separation, and a range of environmental applications. During the FET “HARMONIC” project, two RORs Max Planck-MPIP and NCSR-Demokritos developed complementary technologies for membrane superhydrophobicity, which impart extreme antiwetting, antiscaling and antifouling membranes. The technologies are based on plasma activation or plasma nanotexturing (NCSRD) followed by wet nanofilament growth (MPIP) or plasma deposition (NCSRD) for hydrophobization. Both institutions will advance their technology readiness level so the technology is validated - demonstrated in relevant environment (TRL 5-6), and will design, build, and test small scale pilot equipment for fabricating rolls of superhydrophobic membranes in a roll-to-roll format. For the upscaling of the technology NCSRD and MPIP, will cooperate with two industrial partners, namely Europlasma and SolSep respectively companies with large experience with roll-to-roll plasma or wet processes respectively. Moreover, they will team up with Aquastill, a manufacturer of commercial MD modules for industrial wastewater treatment. A market search and a business plan will be elaborated, for creating a spin-off company commercializing the superhydrophobic membranes, and processes. The range of applications will go well beyond MD.

Keywords: cleaning of industrial waste clean water production membrane distillation membrane desalination plasma processing superhydrophobic membranes entrepreneurship spin off creation