Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Identification, homing and monitoring of therapeutic cells for regenerative medicine – Identify, Enrich, Accelerate (IDEA)

Framework: FP7 — Cooperation
Programme: Health
Destination: Biotechnology, generic tools and medical technologies for human health
Action type: Collaborative project
Countries involved: Germany,Germany,Sweden,Austria,United Kingdom,Czechia,Germany,Germany
Call:  (FP7-HEALTH-2011-two-stage, 2011)
Start date: 2012-03-01
End date: 2017-02-28
Duration (months): 60.0
Total project cost (EUR): 7662775.57
EU funding (EUR): 5897395.0
Participants: 12
Project status: CLOSED

Regenerative medicine focuses on repairing or replacing tissue or organ function lost due to damage or congenital defects using appropriate cells for therapy that have healing capacities like stem cells or progenitor cells. Although regenerative medicine has the potential for more effective therapeutic interventions major improvement in three areas are still needed for a wider establishment of such new concepts in clinical practise: identification of the appropriate cells with healing capacity for the use in therapy, homing of these cells to the damaged tissue, and monitoring of the therapeutic intervention and effect. Thus, a multidisciplinary consortium has set up IDEA, a 60 month collaborative project to develop and establish: • Photonic methods that allow a contact and marker-free identification and selection of cells with healing capacity for vascular, musculoskeletal and neuronal tissue defects; • Magnetic cell select devices that capture and transport cells with healing potential through the circulatory system to damaged tissue and organs improving homing; • Tracer and imaging technologies to monitor the therapeutic effects of interventional regenerative medicine by showing anatomic structure AND demonstrating cellular function using magnetic resonance imaging (MRI) and a new imaging technology known as magnetic particle imaging (MPI). The IDEA project is intended to provide collaboration between scientists and clinicians from Karolinska Institute (Stockholm, Sweden), Kings College (London, UK), Paracelsus Medical University (Salzburg, Austria) and Julius-Maximilians-University (Würzburg, Germany) together with experts from SMEs specialized in photonic technologies for tissue engineering, medical device manufacturing with extensive experience in regulatory approval, the design, synthesis and up-scaling of nanoparticles for molecular imaging, and regulatory affairs. This multidisciplinary consortium will address scale-up, regulatory work and exploratory clinical investigations using the developed tools, technologies and devices in the time frame of the project.

Keywords: regenerative medicine,stem cell,nanoparticles,imaging techniques,test devices,mri,mpi,photonic technologies
Drugging the Undruggable: Discovery of Protein-Protein Interaction Modulators Using Diversity-Oriented Synthesis (DOS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Materials and Synthesis
Countries involved: United Kingdom
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 1499723.0
EU funding (EUR): 1499723.0
Participants: 1
Project status: CLOSED

This proposal aims to exploit diversity-oriented synthesis in order to lay the scientific and technological foundations for the development of enzyme inhibition by protein-protein interaction (PPI) modulation as a tool for chemical biology and molecular therapeutics. We will deploy diversity-oriented synthesis lead discovery to explore concepts for PPI modulation in important enzyme families. This work will yield new chemical entities with a spectrum of properties directed against candidate macromolecular interactions important in the regulation of enzymes that mediate key biological pathways. The proposed work has the potential to transform current approaches to drug discovery, and to radically extend the repertoire of tools available for chemical biology. It will help to address the problem of identifying small-molecule inhibitors of PPIs, widely accepted to be of major fundamental and practical significance to biomedical science.

Keywords: diversity-oriented synthesis chemical genetics protein-protein interactions
STRUCTURE AND DYNAMICS OF PORPHYRIN-BASED MATERIALS IN SOLUTION vs. INTERFACES (PORPHDYN)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physical and Analytical Chemical sciences
Countries involved: Germany
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-09-01
End date: 2016-08-31
Duration (months): 60.0
Total project cost (EUR): 1499000.0
EU funding (EUR): 1499000.0
Participants: 1
Project status: CLOSED

The goal of the proposed project is to perform a systematic study of the electronic structure and the dynamic behaviour of specifically selected metalloporphyrin materials in solution, and at liquid-solid interfaces, with a time resolution covering the range from sub-femtosecond up to picoseconds which is fundamental for their biochemical properties. Metalloporphyrins play a key role in a wide range of processes, such as the light energy conversion in photosynthesis, or in haem proteins performing the transport of small ligands like oxygen. Because of their peculiar optical, electronic and magnetic properties, they are potential candidates for technological applications like in molecular electronics. It is of fundamental importance to gain a detailed understanding of the structural and dynamic properties of these materials under realistic conditions (i.e. ambient pressure, room temperature, and in heterogeneous environments). Soft X-ray spectroscopy is an ideal tool for this purpose, which has recently been implemented by the PI for the investigation of applied materials in the liquid phase, drawing on international recognition of his achievements. Taking advantage from his broad expertise, the PI extended the soft X-ray spectroscopy to biochemical systems in solutions for the first time. Since last year the PI became the youngest group leader at HZB, and Junior Professor at the Freie Universität Berlin. Here, the PI proposes to use the laser pump / soft X-ray probe spectroscopy at first in the sub-picosecond domain. The experiments will extended to femtosecond resolution at the X-ray Free Electron Laser facility. To address sub-femtosecond processes, the systematic scanning of the systems with core-clock spectroscopy is intended. The study will provide fundamental knowledge about the electronic structure and dynamics of metalloporphyrin materials which are essential for different applications, thus helping significantly to enhance their performance.

Keywords: ultrafast dynamics - solution - interfaces - synchrotron - xfel
ENTANGLING AND DISENTANGLING EXTENDED QUANTUM SYSTEMS IN AND OUT OF EQUILIBRIUM (EDEQS)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Fundamental constituents of matter
Countries involved: Italy
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-09-01
End date: 2016-08-31
Duration (months): 60.0
Total project cost (EUR): 1108000.0
EU funding (EUR): 1108000.0
Participants: 2
Project status: CLOSED

It is nowadays well established that many-body quantum systems in one and two spatial dimensions exhibit unconventional collective behavior that gives rise to intriguing novel states of matter. Examples are topological states exhibiting nonabelian statistics in 2D and spin-charge separated metals and Mott insulators in 1D. An important focus of current research is to characterize both equilibrium and non-equilibrium dynamics of such systems. The latter has become experimentally accessible only during the last decade and constitutes one of the main frontiers of modern theoretical physics. In recent years it has become clear that entanglement is a useful concept for characterizing different states of matter as well as non-equilibrium time evolution. One main aim of this proposal is to utilize entanglement measures to fully classify states of matter in low dimensional systems. This will be achieved by carrying out a systematic study of the entanglement of several disconnected regions in 1D quantum critical systems. In addition, entanglement measures will be used to benchmark the performance of numerical algorithms based on tensor network states (both in 1D and 2D) and identify the "optimal" algorithm for finding the ground state of a given strongly correlated many-body system. The second main aim of this proposal is to utilize the entanglement to identify the most important features of the the non equilibrium time evolution after a "quantum quench", with a view to solve exactly the quench dynamics in strongly interacting integrable models. A particular question we will address is which observables "thermalize", which is an issue of tremendous current experimental and theoretical interest. By combining analytic and numerical techniques we will then study the non equilibrium dynamics of non integrable models, in order to quantify the effects of integrability.

Keywords: low dimensional quantum systems,entanglement,quantum quenches,tensor network algorithms,cft,bethe ansatz
New tools for nanoscale optical spectroscopy - Functional imaging of single nanostructures using antennas (NEWNANOSPEC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physical and Analytical Chemical sciences
Countries involved: Germany
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-10-01
End date: 2016-09-30
Duration (months): 60.0
Total project cost (EUR): 1488077.0
EU funding (EUR): 1488077.0
Participants: 1
Project status: CLOSED

Optical microscopy forms the basis of most of the natural sciences. Besides the direct visualization of objects hidden to the unaided human eye, optical spectroscopy – or in other words “colour vision”- is of prime importance providing information on electronic and vibronic properties. In addition, experiments using ultrafast laser pulses provide the highest possible temporal resolution enabling real-time observations of photo-induced processes. Conventional microscopy, however, suffers from diffraction resulting in limited spatial resolution of about 300 nm and low signal levels. The aim of this proposal is to develop novel spectroscopic tools with sub-diffraction resolution. Our approach is based on the localization and enhancement of light-matter interactions using optical antennas. We have shown that antenna-enhanced microscopy provides 10 nm resolution combined with enormous signal amplification and now envision new techniques that extend existing schemes into the femtosecond time-domain with further improved image contrast. Semiconductor nanowires and carbon nanotubes possess unique properties crucial to many areas of technology including communications, alternative energy and the biological sciences. At present, there is a significant lack of understanding regarding the physics of these materials. For example, the correlation between local atomic structure and the resulting optical and functional properties. We will first address fundamental scientific questions arising from highly localized optical probing and explore new phenomena including antenna-enhanced single photon emission and energy transfer. Using our newly developed tools, we will study functional properties of single nanostructures and demonstrate antenna-enhanced light-detection and generation. In summary, our work will lead to fundamentally new optical tools providing unprecedented insights into nanostructures and will substantially advance our understanding of light-matter interactions.

Keywords: carbon nanotubes,nanowires,near-field optical microscopy,raman scattering,photoluminescence,optoelectronics,scanning-probe microscopy
Impurities in Colloidal Materials - tuning the properties of crystals, powders and glasses (IMCOLMAT)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Condensed matter physics
Countries involved: United Kingdom
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-01-01
End date: 2016-12-31
Duration (months): 60.0
Total project cost (EUR): 1499979.0
EU funding (EUR): 1499979.0
Participants: 1
Project status: CLOSED

We aim to establish an multidisciplinary research programme that is focussed on the underlying structural and dynamical processes which determine the intimate relation between impurities and material properties. We propose to exploit the advantages of colloidal model systems and study the impact of impurities on the structural and dynamical properties of crystalline, polycrystalline and amorphous colloidal solids using a combination of state-of-the art fast confocal microscopy and three-dimensional holographic optical laser tweezers. We plan to achieve control over the subtle interplay between glass formation and crystallisation by the tuned addition of impurities. We envisage that our approach will not only offer a direct entry into key mechanisms like impurity drag, but will also allow us to directly and quantitatively measure the central forces at play such as the Zener pinning force. We also aim to study the glass transition from a completely new point of view by tuning the structure using impurities and subsequently ‘freezing-in’ part of the system using holographic optical tweezing. This approach could lead to the determination of a thermodynamic signature of the glass transition, which would put the glass transition in a completely new perspective. In addition, we will investigate the relation between the presence of impurities and the (micro)mechanical properties of doped colloidal materials using (micro)rheological techniques. This ambitious project opens up a huge range of exciting possibilities to gain deep and fundamental understanding of the relation between the (micro)mechanical properties of glasses, polycrystals and crystals and the presence of impurities; a prerequisiute for exploiting these effects in tailoring the properties of materials.

Keywords: optical tweezing,colloids,confocal microscopy
Programmed Nanostructuration of Organic Materials (PROGRAM-NANO)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Materials and Synthesis
Countries involved: Spain
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-11-01
End date: 2016-10-31
Duration (months): 60.0
Total project cost (EUR): 1300932.0
EU funding (EUR): 1300932.0
Participants: 1
Project status: CLOSED

“Program-Nano” aims at establishing unconventional and versatile strategies towards organic architectures whose size, composition, internal structure, and function can be rationally predesigned and controlled. In a bio-inspired manner, we will “program” functional molecules with the required information to self-assemble into unique, well-defined nanofibers or nanotubes. We want to focus on two main ambitious objectives for the application of such organic nanostructured materials. 1) The design and preparation of optoelectronic devices, such as plastic solar cells, where nanostructured fibers are integrated within the active layers. The major goal is to determine the influence of the molecular organization and the morphology at the nanoscale on the performance of the device, and to try in this way to set new records in device efficiency. 2) The fabrication of plastic nanoporous materials for the separation, storage or catalytic transformation of (bio)molecules in which the size, the shape ratio, and the internal functionalization of the nanopores can be custom-tailored.

Keywords: soft condensed matter,nanostructures,plastic electronics,optoelectronic devices,molecular recognition and catalysis
Theoretical multiphoton spectroscopy for understanding surfaces and interfaces (SURFSPEC)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Physical and Analytical Chemical sciences
Countries involved: Norway
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-09-01
End date: 2016-08-31
Duration (months): 60.0
Total project cost (EUR): 1498500.0
EU funding (EUR): 1498500.0
Participants: 1
Project status: CLOSED

The project will develop new methods for calculating nonlinear spectroscopic properties, both in the electronic as well as in the vibrational domain. The methods will be used to study molecular interactions at interfaces, allowing for a direct comparison of experimental observations with theoretical calculations. In order to explore different ways of modeling surface and interface interactions, we will develop three different ab initio methods for calculating these nonlinear molecular properties: 1) Multiscale methods, in which the interface region is partitioned into three different layers. The part involving interface-absorbed molecules will be described by quantum-chemical methods, the closest surrounding part of the system where specific interactions are important will be described by classical, polarizable force fields, and the long-range electrostatic interactions will be described by a polarizable continuum. 2) Periodic-boundary conditions: We will extend a response theory framework recently developed in our group to describe periodic systems using Gaussian basis sets. This will be achieved by deriving the necessary formulas, and interface our response framework to existing periodic-boundary codes. 3) Time-domain methods: Starting from the equation of motion for the reduced single-electron density matrix, we will propagate the electron density and the classical nuclei in time in order to model time-resolved vibrational spectroscopies. The novelty of the project is in its focus on nonlinear molecular properties, both electronic and vibrational, and the development of computational models for surfaces and interfaces that may help rationalize experimental observations of interface phenomena and molecular adsorption at interfaces. In the application of the methods developed, particular attention will be given to nonlinear electronic and vibrational spectroscopies that selectively probe surfaces and interfaces in a non-invasive manner, such as SFG.

Keywords: ab initio theory,molecular properties,nonlinear optics,vibrational spectroscopy,surfaces,interfaces
Charge radius experiment with muonic atoms (CREMA)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Fundamental constituents of matter
Countries involved: Germany
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2011-11-01
End date: 2016-10-31
Duration (months): 60.0
Total project cost (EUR): 1499976.0
EU funding (EUR): 1499976.0
Participants: 1
Project status: CLOSED

A measurement of the 2S-2P transition frequencies (Lamb shift) in the muonic helium-3 and 4 ions by means of laser spectroscopy is proposed. This will lead to a ten times more accurate determination of the root-mean-square (rms) charge radii of the He-3 and He-4 nuclei. The radius of the magnetic moment distribution inside the He-3 nucleus will result from the hyperfine structure in muonic 3He. In the muonic helium ion, a single negative muon orbits the helium nucleus. The muon is a point-like lepton, just as the electron, except it is about 200 times heavier. This gives a factor of 200^3 = 10^7 enhancement of nuclear finite size effects on the energy levels of muonic vs. regular (electonic) Helium ions. Muonic helium is the ideal sytem to study the He nuclear size. The CREMA project has four main aims: (1) Solve the "proton size puzzle" created by our recently completed muonic hydrogen project [R. Pohl et al., "The size of the proton", Nature 466, 213 (2010)]. Our tenfold improvement of the proton charge radius resulted in a five sigma discrepancy with the 2006 CODATA value, which is mostly based on hydrogen spectroscopy. This poses a serious challenge to bound-state QED, and may even point towards new physics. CREMA will help to clarify this. (2) Absolute nuclear charge radii of all helium isotopes He-3,4,6,8 will result from CREMA. The charge radius differences are precisely known, but the absolute size of the He-4 anchor nucleus can best be measured in muonic helium. Absolute charge radii are a more stringent benchmark for few-nucleon nuclear models than the radius difference. (3) Test of bound-state QED: Spectroscopy of regular He+ ions is underway. He+ (Z=2) is more sensitive than hydrogen (Z=1) to higher-order QED contributions which scale as Z^5. An accurate He charge radius from CREMA is mandatory for this. (4) An improved value of the Rydberg constant will result from the He+ spectroscopy only with the improved charge radius from CREMA.

Keywords: laser spectroscopy of exotic atoms muonic helium nuclear charge radii of helium
Accretion and Differentiation of Terrestrial Planets (EARLYEARTH)

Framework: FP7 — Ideas
Programme: European Research Council
Theme: European research council
Destination: Starting grants
Action type: Support for frontier research (ERC)
Panel: Earth system science
Countries involved: Switzerland
Call:  (ERC-2011-StG_20101014, 2011)
Start date: 2012-04-01
End date: 2017-12-31
Duration (months): 69.0
Total project cost (EUR): 1994545.0
EU funding (EUR): 1994545.0
Participants: 1
Project status: CLOSED

This proposal aims to constrain the late accretion history of the Earth and the differentiation of the earliest silicate reservoirs in planets. Highly siderophile elements (HSE) constrain the late accretion of material onto the Earth; a process that potentially delivered water to Earth. During core formation, HSE strongly partition into metal. Once core formation ceases, newly accreted HSE-rich material will significantly contribute to the HSE budget of the Earth’s mantle. The HSE are more abundant in the Earth’s mantle than predicted from low temperature partitioning experiments and feature nearly chondritic relative abundances. This implies a significant late accretion of chondritic material (“the late veneer”). This idea is challenged by high pressure/temperature experiments indicating that the HSE were left in the behind in the mantle during core formation, thereby calling into question the late veneer. To address this issue, I propose the setup of new isotopic tracers and utilize (i) nucleosynthetic anomalies and (ii) stable isotope systematics of the HSE to determine the origin of HSE in the Earth’s mantle. Unravelling this issue is a major advance in understanding planetary accretion. Formation of the earliest silicate reservoirs probably occurred contemporary to late accretion. Global differentiation in terrestrial silicate reservoirs may have taken place within the first 30 million years of the Earth’s formation based on Sm-Nd isotope data. This timing has been debated on various grounds. The 92Nb-92Zr decay system is a potentially powerful chronometer to further constrain this issue. Its usefulness, however, has been hindered by uncertainties of the initial 92Nb abundance in the solar system. I propose to obtain unequivocal evidence from old differentiated meteorites to settle this debate. The results will have implications for understanding early silicate differentiation on asteroids and - depending on the initial 92Nb abundance - the Earth and Mars.

Keywords: terrestrial accretion,silicate differentiation,core fromation,isotope cosmochemisrty,early earth