Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Transformations of Island Societies in the Eastern Mediterranean: a Three-Case Study Analysis (1830-1911) (TransISLES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 209483.28
EU funding (EUR): 209483.28
Participants: 1
Project status: SIGNED

During the 19th century, economic changes (expansion of trade networks and industrialisation) and geopolitical shifts (decline of the Ottoman Empire and rise of nation-states) reshaped the socioeconomic structure of Eastern Mediterranean islands, leading to both new opportunities and the decline of traditional economic activities. Transformations of Island Societies in the Eastern Mediterranean (1830-1911): a Three-Case Study Analysis (TransISLES) proposes a pioneering comparative study on the socioeconomic changes of nineteenth-century island societies in the Aegean and Ionian archipelagoes. The project focuses on three small islands – Thera (Santorini), Tinos, and Ithaca – each of which exhibits distinct political, economic, and social characteristics, integrated into different sea regions and trade networks, serving as representative case studies for Eastern Mediterranean. Using as the main indicator of analysis the family unit in its demographic, social, economic, and material context, TransISLES aims to examine how transformative processes in the Eastern Mediterranean affected the socioeconomic fabric of these islands, revealing differences and commonalities across geographical areas and social groups. The project adopts an interdisciplinary approach that combines maritime history, island studies, family history, demographic history, gender studies, and material culture studies, together with the integration of digital humanities tools. Through a two-tiered analysis, merging macro-level quantitative studies of demographic and occupational data with micro-level examinations of individual families, TransISLES will explore the evolution of social and economic hierarchies, patterns of social mobility, cultural perceptions of socioeconomic status, and gender regimes on these islands. TransISLES will address critical research gaps and offer a groundbreaking contribution to understanding how island societies adapted to significant political and economic changes.

Keywords: maritime history,island studies,nineteenth century transformations,industrialisation,nation state building,material culture studies,family history,eastern mediterranean,mediterranean history
Menstrual blood multiomics analysis to better diagnose, understand and treat endometriosis (MultiMENDo)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2022-STG, 2022)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1479399.0
EU funding (EUR): 1479399.0
Participants: 2
Project status: SIGNED

The MensEndoDiag project aims at finding diagnostic biomarkers and prognostic biomarker candidates, as well as investigating new therapeutic approaches for endometriosis using menstrual fluid, an easily accessible yet overlooked biological fluid. Endometriosis is a common gynecological disorder affecting 6-10% of women of childbearing age. It is associated with pelvic pain and infertility. It leads to a reduced quality of life and is an economic burden. It is defined by the presence of endometrial tissue outside the uterus. Endometriotic lesion form from retrograde menstruation (menstrual fluid reflux through the fallopian tubes) but the precise pathogenesis remains unclear. There are no noninvasive biomarkers currently used in clinical care but they are essential to improve the diagnosis delay, currently estimated at 8 years. There is no specific treatment and pharmacological options are contraceptive. Here, I propose to use menstrual fluid as a relevant biological fluid for endometriosis. In Aim 1, single-cell transcriptomics and soluble protein multiplex assays on 64 menstrual fluid samples will be used to identify candidate diagnostic biomarkers that differentiate endometriosis affected women from healthy controls. Validation of these biomarkers will be carried out in menstrual fluid samples from 250 women. In Aim 2, menstrual fluid derived organoids cultured with or without immune cells will be used to assess endometriosis associated functional changes and to test new immunomodulatory treatments. In Aim 3, longitudinal cohorts will be established to identify prognostic candidate biomarkers for response to surgery and in vitro fertilization. Diagnostic and prognostic biomarkers are essential to assess disease establishment, evolution and to choose the most appropriate treatment. This project will enhance our understanding of endometriosis pathophysiology as well as allow the study of a new biological fluid, relevant to gynecologic and reproductive disorders.

Keywords: endometriosis,gynecology,fertility
Increasing Self-Knowledge to Promote Moral Behavior (KNOW-THYSELF)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 1499130.0
EU funding (EUR): 1499130.0
Participants: 1
Project status: SIGNED

The functioning of societies and the quality of interpersonal relationships heavily depend on moral behaviors such as fairness, cooperation, and honesty, whereas immoral behaviors bear tremendous societal costs. A long-standing puzzle facing the social sciences and the humanities is how to promote moral behavior. The prevalent approach is to modify the situation, e.g., through implementing rewards for moral and sanctions for immoral behavior or through nudging. Community and organizational policies invariably resort to such interventions to foster moral action. However, situation-based approaches are distinctly limited: they inhibit more consistent behavior change that extends to situations where the intervention is absent, and they often fail or even backfire. In KNOW-THYSELF, I pursue a person-centered approach that can more widely and sustainably promote moral behavior than existing approaches. I draw on a yet unexploited resource for desirable behavior change rooted in ancient Greek philosophy: self-knowledge, defined as an accurate representation of what one is like. In the moral domain in particular, self-knowledge is restricted by self-enhancement – the pervasive bias to see oneself more favorably than implied by one's actions. I propose that increasing self-knowledge about moral character can promote moral behavior across contexts and even give rise to long-term change of personality traits that underlie moral action. Adopting a multi-disciplinary perspective and combining rigorous experiments with cutting-edge field methods (e.g., experience sampling), I address three key challenges: (1) How to advance self-knowledge most effectively (2) Increase self-knowledge to promote moral behavior (3) Increase self-knowledge to initiate long-term personality change Tackling these challenges offers ground-breaking insights for theory, research, and practice into how self-knowledge can be advanced and utilized to boost moral behavior – in the short- and long-term.

Keywords: self knowledge moral behavior moral character moral identity self perception personality change prosocial behavior ethical behavior
Participative Assistive AI-powered Tools for Supporting Trustworthy Online Activity of Citizens and Debunking Disinformation (AI4Debunk)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Innovation actions
Countries involved: Latvia,Belgium,Ukraine,Italy,Ireland,Netherlands,Spain,Greece
Call: Through AI from Disinformation to Trust (IA) (HORIZON-CL4-2023-HUMAN-01-CNECT, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 5245887.87
EU funding (EUR): 4895182.51
Participants: 14
Project status: SIGNED

AI4Deunk aims to develop 4 human-centered AI-powered interfaces: a web plug-in, a collaborative platform, a smartphone app, and an AR interface. All these solutions will be built upon a "debunking" API. To develop such an API, AI4Debunk will focus on 2 peculiar disinformation topics: the war in Ukraine and disinformation related to climate change. By deeply analysing these case studies thanks to sociological experts (targets groups, sources, way of diffusion...), we will map disinformation contents on knowledge graphs, and compare them to existing databases thanks to AI methods such as NLP. These knowledge graphs will be the skeleton of our technical work: one will be multimodal meaning that all types of modalities (written content, image, video) will be directly embedded, while the monomodal will be only about written content (the different modalities will be previously embedded into written content). Then debunking modules will be developed, for each type of modality, based on AI and ML methods that could detect and examine questionable content, by comparing it to the context extracted from the knowledge graphs. RNN, CNN, multi-modal language interpretation, and transformers methods will be used to that extent. The goal of such modules is to give a score of fakeness, which we will call Disinofscore, for content given as input. The API will then integrate this method and will be the bases of the 4 interfaces abovementioned. The plugin will allow people to be instantly noticed when a content they are considering is fake or true, the collaborative platform - also called Disinfopedia, will allow more proactive online users to report questionable content, that will be checked by a debunking committee chaired by a senior analyst, the app interface will allow people to check content in their everyday life, while the AR interface will allow citizens to have hindsight on the incoming generation of fake news and social media.

Keywords: case studies,multimodal knowledge graph,human centered interfaces,web plug in,collaborative platform
Novel approach for the accurate quantitation of micro/nanoplastics in environmental compartments: a spatial-temporal distribution study in Valencia, Spain (AQUPLAST)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: CLOSED

Plastic pollution is an issue of environmental concern intensively discussed in the scientific literature and public media in recent years. Particularly, microplastics (MPs) and/or nanoplastics (NPs) are a kind of pollutants potentially hazardous for ecosystems and human health that can be ingested by aquatic fauna. In this context, the presence of MPs and a lesser extent of NPs have been reported in the environment and biota. However, the detection of these pollutants generally it happens through techniques that allow its identification and characterization but have not enough sensitivity and/or accuracy to provide quantitative reliable results. Therefore, this project will focus on developing an accurate and reliable analytical procedure by liquid chromatography coupled to high resolution mass spectrometry for monitoring the occurrence and spatial-temporal distribution of MPs and NPs in environmental compartments and the further risk assessment in environmental and human health. This project shows an interdisciplinary nature that involves environmental, analytical chemistry and social sciences research field. This latter, considering the anthropogenic approach of this action. In addition, this proposal includes a two-way transfer of knowledge between the researcher and the host institution, as well as the training of the researcher in new advanced techniques both at the host as partner institution. The results of this project will allow to correlate the presence of MPs and NPs with anthropogenic and seasonal factors through accurate analytical methodologies. Moreover, it will allow a better understanding of risks of MPs and NPs pollution for environmental and human health, providing data that could be used by policymakers. To emphasize, this project is aligned with the European Union strategy of developing accurate analytical methods for quantify MPs and NPs in environmental matrices and biota in order to perform appropriate risk assessment.

Keywords: micro nanoplastics,analytical methodologhy development,liquid chromatography coupled to high resolution mass spectrometry,spatial temporal monitoring,environmental and human health risk assessment
European Social Science Genetics Network (ESSGN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Netherlands,France,United Kingdom,Norway,Germany,Sweden
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2023-03-01
End date: 2027-02-28
Duration (months): 48.0
Total project cost (EUR): 2766103.2
EU funding (EUR): 2766103.2
Participants: 16
Project status: SIGNED

The European Social Science Genetics Network (ESSGN) brings together seven academic beneficiaries with a shared interest in social science genetics, i.e., in incorporating genetic information to improve our understanding of age-old questions in the social sciences, such as the origins of inequality, the ‘nature versus nurture’ debate, and the extent to which the interplay between environments and genes is important in shaping individuals’ lives. The consortium consists of an interdisciplinary group of academics, as well as seven non-academic partners committed to using data science to address inequalities in life chances. There is an urgent need for training in social science genetics due to recent technological advances in genetics, the intricacies of using genetic data, and the growing availability of such data in surveys traditionally studied by social scientists. Our aim is to train the next generation of social scientists in the responsible and technically correct use of genetic data and in objective communication about what can and cannot be learned from working with genetic data in the social sciences. The project will go beyond the state-of-the-art (i) by using Europe’s most comprehensive multigenerational databases to separate direct genetic effects from parental genetic and socio-economic factors that shape the rearing environment; and (ii) by exploiting the large toolbox of causal inference methods used in econometrics and statistics to estimate the extent to which environments causally protect individuals with genetic disadvantages. We will (1) analyse to what extent genetic (‘nature’) and environmental (‘nurture’) factors contribute to equality of opportunity and intergenerational mobility, and (2) establish how nature and nurture jointly shape inequalities in life chances. As such, our programme of research provides novel and exciting opportunities to social scientists to deepen our understanding of how inequalities in life chances are shaped.

Keywords: social science genetics,inequalities
Pro-active Pandemic Crisis Ethics and Integrity Framework (PREPARED)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Netherlands,France,Germany,Cyprus,Finland,China,Lithuania,United Kingdom,Switzerland,Kenya,Ireland,India,Korea, Republic of,South Africa
Call: The challenges of research ethics and integrity in response to crisis: the coronavirus pandemic and beyond (HORIZON-WIDERA-2021-ERA-01, 2021)
Start date: 2022-09-01
End date: 2025-08-31
Duration (months): 36.0
Total project cost (EUR): 4201758.75
EU funding (EUR): 4201758.75
Participants: 16
Project status: SIGNED

The overall goal of the PREPARED project is to develop an operational ethics and integrity framework, which safeguards key ethical values, supports a rapid and effective research response to crises and improves overall pandemic preparedness. European Commission president Ursula von der Leyen outlined plans to cope with "an era of pandemics" by developing "Europe-wide fast-reaction system designed to respond more quickly to emerging medical threats". Fast reaction systems, including accelerated research, are likely to face significant ethics and integrity challenges. The PREPARED project will create an international network of research funders (private and public), researchers, policy makers, publishers and citizens (a) to identify, analyse and validate the emergent research ethics and integrity challenges in the context of sudden, unexpected and global crisis, (b) to facilitate bottom-up, solution-focused, participatory dialogue, (c) to develop a values-based framework for research ethics and integrity in a global crisis which supports rapid and effective decision-making whilst maintaining scientific reliability and avoiding short-cuts in the protection of research participants, (d) to propose policy options at the EU level and tailored support for relevant stakeholders in the form of operational guidelines and short complements to existing codes and (e) to achieve influential strategic engagement through high-level synergy building and the provision of engaging training material to ensure uptake of the project's outputs so as to improve overall preparedness for global crises. Given that this is a Coordination and Support Action, the high-level consortium consists to 47% of research institutions (given that this is a CSA) and to 53% of organisations which can significantly contribute to and then leverage results (e.g. UNESCO, EDCTP, RIS).

Keywords: pandemic ethics,research integrity,research ethics,public health ethics
Protein nanocage-scaffolded proteoliposomes: de novo design of a platform for bacterial vaccines (ProNanovoVax)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-04-01
End date: 2028-03-31
Duration (months): 24.0
Total project cost (EUR): 200400.0
EU funding (EUR): 200400.0
Participants: 1
Project status: CLOSED

Pathogenic bacteria pose significant threats to the global healthcare and the economy. Amid growing concerns over antimicrobial resistance, many healthcare programs have pivoted to vaccine development, while new vaccine platforms are in a high demand for disease control and swift responses in the case of health emergencies. A major type of bacterial immunogen is transmembrane beta-barrel (TMB) proteins, which are found on the outer membrane of Gram-negative bacteria and play key roles in virulence. The native folding and trafficking of TMBs requires specific machineries that do not exist in eukaryotic cell membranes. Consequently, there has been few vaccine platforms for TMB immunogens. To address this need, I aim to construct protein nanocage-scaffolded proteoliposomes (PNC-PL) that can act as highly potent nanoparticle vaccine platforms for TMBs. Such nanomaterial will be developed using two cutting-edge strategies in vaccine formulation: multivalent presentation and immune targeting. Combining my strong background in PNC engineering and my host lab’s expertise in TMBs and their computation-assisted design, (1) I will multivalently present computationally engineered TMB immunogens on PNCs in a well-controlled manner, resulting in vaccines composed of PNC-PL nanoparticles that mimic the structures of enveloped viruses. (2) I will design transmembrane anchors using computation-assisted methods to host soluble protein ligands that recognize immune cells. The resultant complexes will be subsequently co-presented with TMB immunogens on PNC-PLs for immune targeting, which will further increase the vaccine potency. (3) With my co-host lab’s rich immunological resources, I will assess immune cell activation induced by the vaccines as a criterion of potency. This novel nanosystem will hold great promise to advance vaccine design with challenging immunogens and serve as a versatile technology for biomaterial design in drug delivery, artificial cells, and other applications.

Keywords: membrane protein,protein nanocage,proteoliposome,computational protein design,nanoparticle,immune targeting