Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Novel diagnostic and therapeutic approach to inflammatory bowel disease based on functional characterization of patients: the CrUCCial index (CrUCCial)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Belgium
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-09-01
End date: 2022-08-31
Duration (months): 72.0
Total project cost (EUR): 2494500.0
EU funding (EUR): 2494500.0
Participants: 1
Project status: CLOSED

The clinical phenotype and the outcome of Crohn's disease (CD) and ulcerative colitis (UC), the opposite ends of chronic inflammatory bowel diseases (IBD), are heterogeneous and represent the result of a complex interplay of the gut microbiome with the immune system in genetically predisposed individuals. Disease management is much less heterogeneous as all patients are treated using non-specific anti-inflammatory agents, and only 30-50% achieve clinical and mucosal remission -the goal of therapy nowadays- therefore leaving large margins for improvement. The advances in knowledge about the factors triggering disease onset should be translated to approach the disease from a molecular angle. Key cellular pathways have emerged including bacterial recognition, autophagy, endoplasmic reticulum stress and intestinal barrier function. Functional/molecular characterization of these pathways in a given patient, correlation with meaningful clinical outcomes, and tailoring an individual therapeutic approach has never been attempted and will represent a breakthrough in the current paradigm of treating multifactorial inflammatory conditions. This project aims to functionally characterize patients with CD/UC for the major pathways by using integrated (epi)genetic, transcriptomic, immunologic, barrier integrity and metagenomic studies. From these readouts we will construct an index [the Crohn’s and Ulcerative Colitis Characterization and Intervention trial (CrUCCial) index], reflecting the proportional contribution of each of the pathogenic mechanisms in a given patient. We will next study the correlation of this index and its components to meaningful clinical outcomes and finally, the index will be tested in a pilot study of newly diagnosed patients in whom the disease will be targeted individually based on the components of the CrUCCial index. Our approach, from diagnosis over prognosis to therapy, will revolutionize the paradigm of disease management.

Keywords: inflammatory bowel diseases,crohn s disease,ulcerative colitis,immune mediated inflammatory disorders,dysbiosis,intestinal barrier
ASCEMA: Content Aware Technology for IP Protection in Supply Chains (ASCEMA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: United Kingdom
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-06-01
End date: 2016-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Manufacturers increasingly rely upon development in the supply chain; e.g. a typical automotive company has 60% of components manufactured in the supply chain. A significant level of resistance, to sharing and enforcement of IP, is damaging supply chain partnerships and the manufacturing production processes that rely upon them; costs to industry estimated at millions of euro (NFF Symposium, 2013). This project, spanning 6 months, will investigate the feasibility of bringing to market a novel solution for protecting intellectual property across enterprise boundaries and will support a go to market plan for Ascema for Supply Chains, a patented technology that protects high value content across enterprise boundaries. The European Parliament " Recognises that the enforcement of IPR is not merely a driver for jobs and growth across the Union but is essential for the proper functioning of the single market and plays a key role in stimulating innovation, creativity, competitiveness and cultural diversity." (Towards a renewed consensus on the enforcement of IPR: An EU Action Plan, May 15). Ascema offers a disruptive solution where currently no other solutions exist. This project will undertake a feasibility study, including a full business plan, to verify the technological, practical and economic viability of GeoLang’s novel Ascema for Supply Chains data loss prevention platform. A planned Phase 2 project will provide a preproduction prototype of a digital information fingerprinting and tracking mechanism across boundaries with processes and requirements for inclusion within supply chain contractual arrangements identified that will support the market take-up of this novel platform which has won GeoLang Ltd the prize of UK's Most Innovative Small Cyber Security Company 2015. The results will support the uptake by industry of a technology that offers safe sharing of intellectual property in supply chains facilitating growth within the single market.

Keywords: ip protection,data loss prevention,supply chain,content aware
Development of functional organization of the visual circuits in mice (CIRCUITASSEMBLY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Denmark
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-04-01
End date: 2020-03-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: CLOSED

The key organizing principles that characterize neuronal systems include asymmetric, parallel, and topographic connectivity of the neural circuits. The main aim of my research is to elucidate the key principles underlying functional development of neural circuits by focusing on those organizing principles. I choose mouse visual system as my model since it contains all of these principles and provides sophisticated genetic tools to label and manipulate individual circuit components. My research is based on the central hypothesis that the mechanisms of brain development cannot be fully understood without first identifying individual functional cell types in adults, and then understanding how the functions of these cell types become established, using cell-type-specific molecular and synaptic mechanisms in developing animals. Recently, I have identified several transgenic mouse lines in which specific cell types in a visual center, the superior colliculus, are labeled with Cre recombinase in both developing and adult animals. Here I will take advantage of these mouse lines to ask fundamental questions about the functional development of neural circuits. First, how are distinct sensory features processed by the parallel topographic neuronal pathways, and how do they contribute to behavior? Second, what are the molecular and synaptic mechanisms that underlie developmental circuit plasticity for forming parallel topographic neuronal maps in the brain? Third, what are the molecular mechanisms that set up spatially asymmetric circuit connectivity without the need for sensory experience? I predict that my insights into the developmental mechanism of asymmetric, parallel, and topographic connectivity and circuit plasticity will be instructive when studying other brain circuits which contain similar organizing principles.

Keywords: retina,superior colliculus,retinal ganglion cells,motion sensitive neural circuits,cell types,computation,two photon imaging,trans synaptic tracing,optogenetics,transcriptome,transgenic mice
Duality For Logic On Words (DFLOW)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Mathematics
Countries involved: Netherlands,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 242929.8
EU funding (EUR): 242929.8
Participants: 2
Project status: CLOSED

Duality For Logic on Words (DFLOW) The mathematical theory of Stone duality underlies a deep connection between syntax and semantics in logic and theoretical computer science, and allows for powerful applications in both of these research fields. The aim of this project is to apply the topological methods provided by Stone duality to the study of the expressive power of logic in describing formal languages of both finite and infinite words. During the outgoing phase of the project, at the Mathematics Department at the City College of the City University of New York, the applicant will perform an in-depth study of profinite semigroups and their applications in formal language theory, through the lens of Stone duality and finite model theory. In particular, recent insights from duality theory will be applied to obtain tractable combinatorial descriptions of the free profinite objects for logic fragments of varying expressive power. During the return phase to Europe, to the Institute for Logic, Language and Computation at the University of Amsterdam, the applicability of duality theory will be extended to streams and data words. To this end, the knowledge and skills obtained during the outgoing phase will be combined with the existing local expertise on logic and coalgebra in Amsterdam. During both phases, the hands-on research training will be complemented by training activities to further enhance the applicant's skills in networking, collaboration, teaching, communication and management. The project, taking place at the interface of mathematics and computer science, has the potential to make a significant impact in three different ways: by advancing the research on Stone duality and formal language theory, by facilitating a new collaboration between the European host institute and a world-leading mathematics department in the USA, and by establishing the applicant's position as a leading young researcher in his field.

Keywords: stone duality,profinite algebra,semigroup theory,automata,coalgebra
Mitochondrial regulation of structural and functional plasticity within adult neurogenic circuits (MITOPLASTICITY)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Neuroscience and Disorders of the Nervous System
Panel description: Nervous system development, homeostasis and ageing, nervous system function and dysfunction, systems neuroscience and modelling, biological basis of cognitive processes and of behaviour, neurological and mental disorders
Countries involved: Germany
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-08-01
End date: 2021-11-30
Duration (months): 64.0
Total project cost (EUR): 1199987.5
EU funding (EUR): 1199987.5
Participants: 1
Project status: CLOSED

A fundamental question in neuroscience is to reveal the energy constrains governing the plasticity of brain circuits. Mitochondrial energy metabolism is increasingly recognized for regulating the activity and integrity of existing synaptic terminals, however it is unclear how changes in mitochondrial function are coupled with the generation of new neurons and the ensuing circuit remodelling, e.g. in response to experience or disease. We have recently shown that a regionalized restructuring of the mitochondrial network in astrocytes upon cortical injury underlies their ability to enter a state of reactivity and sustain cellular energy metabolism, suggesting that local changes in mitochondrial network architecture govern cellular adaptations in register with local metabolic demand. Here, I focus on the adult hippocampal circuitry and its almost unique structural plasticity to broaden this fundamental concept and evaluate whether local mitochondrial remodelling orchestrates the metabolic changes underlying the directed genesis of new neurons and their evolving connectivity in face of experience. First, we will utilize state-of-the-art imaging and genetic techniques to investigate the precise role of mitochondria in regulating adult neural stem cells (NSCs) quiescence, mode of division and neurogenic potential in response to experience. This will set the stage for examining whether state-specific energy metabolism programs regulate the fate plasticity of adult NSCs, as following their directed differentiation towards distinct lineages in vivo (Aim I). We will then elucidate whether mitochondria contribute to mechanisms of metabolic and synaptic competition in new neurons, in particular to their critical period of heightened structural and functional synaptic plasticity (Aim II). Lastly, we will use novel tracing techniques to dissect the local energy needs for activity- and experience-dependent remodelling of new neuron functional connectivity (Aim III).

Keywords: synaptic plasticity,adult neurogenesis
Holistic Approach of Spray Injection through a Generalized Multi-phase Framework (HAoS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Australia,Germany,Germany,Sweden,Greece,France,United States,United Kingdom,United Kingdom,Luxembourg,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2015, 2015)
Start date: 2015-11-01
End date: 2019-10-31
Duration (months): 48.0
Total project cost (EUR): 3857734.84
EU funding (EUR): 3857734.84
Participants: 14
Project status: CLOSED

Development of fuel injection equipment (FIE) able to reduce pollutant emissions from liquid-fueled transportation and power generation systems is a top industrial priority in order to meet the forthcoming EU 2020 emission legislations. However, design of new FIE is currently constrained by the incomplete physical understanding of complex micro-scale processes, such as in-nozzle cavitation, primary and secondary atomization. Unfortunately, today’s computing power does not allow for an all-scale analysis of these processes. The proposed program aims to develop a large eddy simulation (LES) CFD model that will account for the influence of unresolved sub-grid-scale (SGS) processes to engineering scales at affordable computing time scales. The bridging parameter between SGS and macro-scales flow processes is the surface area generation/destruction occurring during fuel atomisation; relevant SGS closure models will be developed through tailored experiments and DNS and will be implemented into the LES model predicting the macroscopic spray development as function of the in-nozzle flow and surrounding air conditions. Validation of the new simulation tool, currently missing from today’s state-of-the-art models, will be performed against new benchmark experimental data to be obtained as part of the programme, in addition to those provided by the industrial partners. This will demonstrate the applicability of the model as an engineering design tool suitable for IC engines, gas turbines, fuel burners and even rocket engine fuel injectors. The proposed research and training programme will be undertaken by 15ESRs funded by the EU and one ESR funded independently from an Australian partner; ESRs will be recruited/seconded by universities, research institutes and multinational fuel injection and combustion systems manufacturers that will represent in the best possible way the international, interdisciplinary and intersectoral requirements of the Marie Curie Action guidelines.

Keywords: automotive ic engines,aero engines,rocket engines
Communists into Liberals: The Transformation and Demise of the Left as Precursor to the Illiberal Turn in Poland (COMLIB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-10-01
End date: 2021-09-30
Duration (months): 24.0
Total project cost (EUR): 175673.28
EU funding (EUR): 175673.28
Participants: 1
Project status: CLOSED

Communists into Liberals: The Transformation and Demise of the Left as Precursor to the Illiberal Turn in Poland ‘Communists into Liberals’ (COMLIB) seeks a historically grounded explanation to the recent ‘illiberal turn’ in Poland by pursuing a new line of inquiry into the country’s transition from state socialism to a European liberal democracy. Rather than focusing on relatively short-term political and economic structural contingencies, the project aims to bring both historical process and agency of key protagonists to the fore as a factor precipitating the developments of the past years. In doing so, three historical processes spanning from 1968 to the mid-2000s are placed in correlation to each other: the demise of communism and transition to liberal democracy in Poland, exchanges of ideas that transcended the Cold War divide of Europe, and the political trajectory of the Polish and European Left. Within this framework, the project examines the agency of a particular group of politicians and activists from the Polish Left and investigates how their ideas and policies set the stage for the recent so-called ‘illiberal turn’ fueled by populism of the Right. In doing so, it aims to re-examine the dynamics of reform communism prior to 1989 as well as its impact on the transition afterwards highlighting two issues: the ‘social-democratisation’ of communism and the ‘neoliberalisation’ of social democracy. COMLIB’s working hypothesis is that the Polish Left’s gradual abandonment of social democratic values during the post-communist transition contributed to their demise in the mid-2000s and facilitated the ‘illiberal turn’. The project’s methodological framework adopts a collective biography approach based on oral history, archival research and qualitative analysis of written sources.

Keywords: polish history and politics,eastern europe,communism,post communism,social democracy,liberal democracy,neoliberalism,party reformers,post 1989 transition,european left,illiberal turn
EXperimentation and simulation based PLatform for beyond 5G Optical-wireless network Research and development (EXPLOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Greece,United Kingdom,Portugal
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2019, 2019)
Start date: 2020-01-01
End date: 2024-08-31
Duration (months): 56.0
Total project cost (EUR): 883200.0
EU funding (EUR): 883200.0
Participants: 4
Project status: SIGNED

The EXPLOR project proposes the development of a comprehensive modular software with fully validated state of the art (SOTA) component and system level numerical models, cognitive and adaptive features, as well as libraries with novel use cases and scenarios targeting Next Generation (NG) converged Optical Wireless Networks (OWN). EXPLOR platform will be modelled to enable deep academic and techno-economic considerations of relevant beyond 5G (B5G) features in an integrated fashion, such as high mm-Wave (MMW) frequency Optical Front-haul (OFH), femtocell based communications, network cognition and Cloud-RAN (CRAN) environment functionalities. Novel, beyond SOTA models and system architectures will be pursued and included in the integrated EXPLOR platform. Relevant interface and feedback functionalities designed to enable modular inclusion of external, user generated scripts and satisfactory latency versus accuracy trade-offs will be pursued. As such, the platform development will lead to a number of relevant research outcomes in the field, as well as act as an extensive enabler of future innovation beyond 5G networks.

Keywords: beyond 5g networks,optical wireless networks,thz communications,mmwave transmission,software defined transceivers,machine learning,artificial intelligence,cloud ran,network virtualization
Mechano-activated Extracellular Vesicle Based Repair of Bone (EVERBONE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Ireland
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 149891.25
EU funding (EUR): 149891.0
Participants: 1
Project status: CLOSED

Every 30 seconds a person suffers an osteoporosis-related bone fracture in Europe, resulting in significant morbidity, mortality and healthcare costs estimated at €36billion annually. Current anti-catabolic therapeutics are associated with severe side effects and are purely preventative, while the only anabolic treatment plateaus at 6 months. This has resulted in a crisis in osteoporosis treatment. Therefore, the aim of EVERBONE is to develop and commercialise a new anabolic multitargeted medicinal product for bone regeneration that mimics the beneficial effects of physical exercise, by recruiting endogenous cells to promote angiogenesis, osteogenesis and bone formation. Building on the discovery that osteocyte-derived mechanically activated extracellular vesicles (MAEVs) mediate the anabolic bone forming response to physical exercise, this project will develop novel bioreactor systems to increase MAEV yield in vitro and scale up for clinical use. Secondly, it will identify a standard mechanical conditioning procedure to generate optimised angiogenically and osteogenically primed MAEVs. Finally, preclinical evaluation of MAEV treatment will be performed in a model of osteoporosis and bone healing, whereby it is expected that MAEVs will localize to bone and mobilise endogenous endothelial and stem cell populations to enhance bone regeneration in osteoporosis and improved healing rates in bone defects. This regrowth of bone will overcome current limitations of anti-resorptive treatments, reducing the risk of fracture and thus the financial burden of treatment. The project will leverage the applicants experience in bone mechanobiology to develop a new product with significant commercial potential. Therefore, the impact of EVERBONE will be multifaceted: it will transform how osteoporosis is treated, it will create economic value through the commercialisation of IP, and most importantly it will improve patient experience and their long-term health and well-being.

Keywords: bone,mechanobiology,osteocyte,extracellular vesicle,osteoporosis,regenerative medicine