Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Cellular Dynamics of Intestinal Antibody-Mediated Immune Response (GutBCells)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Israel
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-05-01
End date: 2021-04-30
Duration (months): 60.0
Total project cost (EUR): 1375000.0
EU funding (EUR): 1375000.0
Participants: 1
Project status: CLOSED

Vaccination is widely used to prevent human diseases by inducing the formation of cellular and antibody-mediated immune responses for induction of long lasting immunological memory. Although most studies focus on immune responses elicited against injected immunizations, the simplest delivery of a vaccine regimen is by oral administration. The cellular and molecular components of the antibody immune response in peripheral lymph nodes in response to immunization are well described, however, much less is known about the dynamics of immune cells in gut associate lymphoid tissues (GALT) and adjust intestinal mucosal tissues. In the proposed research plan I will implicate intravital in vivo imaging for analysis of the cellular component of the antibody immune response in intestinal tissues. My goals are: 1. To track germinal center (GC) T cells for prolong time periods in peripheral lymph nodes and GALT and determine if they enter the memory compartment. For this purpose I will develop a new photoactivation method for permanently labeling immune cells and fate tracing of their daughter cells. 2. To examine T-B interactions and their regulation by intraceullar signaling pathways in GALT and to determine where and when class switch recombination to IgA takes place. For this purpose I will use intravital imaging of fluorescent reporter mice. 3. I will analyze the dynamics of plasma cell migration from Peyer’s patches to the mucosa by implementing state of the art photoactivation and imaging techniques that allow prolonged cell tracking. I will also use photoactivation approaches for sorting plasma cells from specific intestinal layers and perform gene expression analysis. 4. I will develop a new method to study dynamics and fate of B cells specific for commensal microbes in the GC, memory and plasma cell compartments. This research plan will extend our knowledge of the antibody immune response in intestinal tissues towards the future design of improved oral vaccinations.

Keywords: antibodies,germinal center,b cells,payer s patches,plasma cells
An innovative approach for the study of culinary practices in past societies (CUISINE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-05-01
End date: 2019-09-06
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The aim of this project is to develop an innovative methodology for the study of culinary practices (cuisine) in past societies integrating the morpho-typological analysis of cooking pots, the analysis of their lipid content and the analysis of microbotanical remains. By analysing a society's diet and cuisine we can explore, for instance, cultural development expressed through growing complexity in parallel with the development of more complex social and technological structures. This project will explore culinary practices in past societies through the integrated analysis of phytoliths, starch grains and lipids from cooking pottery. In order to interpret the archaeological record, extensive plant reference collections and several experiments will be developed as part of the project. At the same time, the methods developed during the experimentation phase will be tested and validated on two archaeological case studies in the Aegean, an area that has historically been (and still is) a crossroad for people and foodstuffs: the Neolithic site of Stavroupoli (Greek Macedonia, ca. 5600-5000 cal. BC) and the Bronze Age site of Knossos-Gypsades (Minoan Crete, ca. 3650-1100 cal. BC). The development of these integrated analyses on Neolithic and Bronze Age settlements will allow for the study of the emergence of new social practices and cultural identities linked to the origins of food production and the development of complex, urban societies.

Keywords: archaeology,microbotanical remains,lipid analysis,pottery,cuisine
The first microalgae platform for the production of anticancer biopharmaceuticals (MABIOS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Netherlands
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Manufacturing costs remain one of the major obstacles to providing effective treatment of cancer patients. Anticancer agents are often complex biopharmaceuticals that are expensive to manufacture, requiring use of living cell lines with difficult-to-control production processes, limited yields and time-consuming purification steps. There is an urgent unmet need for an improved manufacturing process of biopharmaceuticals, to meet the high demand and lower the price of oncologic treatments. We will revolutionize the way biopharmaceuticals are produced by developing a microalgae based biorefinery platform. These biorefineries will utilize genetically engineered microalgae to efficiently produce pharmaceutical agents. Microalgae are photosynthetic micro-organisms that have unique advantages as biopharmaceutical production systems, including high growth rate, ease of cultivation and low growth costs, enabling cost effective and scalable yield of active ingredients. These will be recombinant proteins, small molecules or therapeutic peptides, starting with Paclitaxel as showcase, one of the world’s best sold anticancer drugs used as the first line treatment of a several solid tumours. Our platform has the potential to become the new manufacturing method of choice for production of highly needed biopharmaceuticals. Microalgae Works is an ambitious Dutch start-up with the mission to make anticancer treatment affordable for every patient through a drastic reduction of manufacturing costs. We are supported by leading companies in the field of biomanufacturing. The MABIOS project will (1) create a clear overview of the market opportunity for micro-algae based production of paclitaxel, (2) develop a de-risked plan for the technical development of our platform, (3) evaluate the necessary regulatory roadmap to enter the market, and (4) formulate an investor-proof business plan. We aim to become the frontrunner in biopharmaceutical production utilizing microalgae.

Keywords: microalgae platform,photobioreactor,metabolic engineering,biomanufacturing,biopharmaceuticals,anti cancer agents,paclitaxel,taxol,biosimilars
Molecularly defined models of human childhood brain tumors (Medulloblastoma)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2014-STG, 2014)
Start date: 2015-05-01
End date: 2020-04-30
Duration (months): 60.0
Total project cost (EUR): 1497059.0
EU funding (EUR): 1497059.0
Participants: 1
Project status: CLOSED

MYC proteins like MYC and MYCN are transcription factors that are mis-regulated in more than half of all types of human cancer including medulloblastoma, the most common brain malignancy in children. The two main challenges that can guide research in the field of pediatric brain tumors is improving survival and reducing long-term detriments due to treatment toxicities, especially from craniospinal radiotherapy. Medulloblastoma is suggested to originate from specific cells in the small brain, cerebellum. These brain tumors have recently been classified into four distinct molecular subgroups and subgroup-specific driver genes have been suggested. However, the precise role of such drivers in tumor initiation and their importance in specifying particular subgroups has not been sufficiently evaluated in proper cells of medulloblastoma origin. We have generated clinically relevant animal models that carefully resemble some of the defined subgroups of medulloblastoma. In this proposal we intend to use the models to identify the specific cell type these brain tumors originates from. We also aim to refine our medulloblastoma models and develop novel models to define and study cells involved in brain metastasis and tumor recurrence; the main cause of death in brain tumor patients. We have managed to culture normal human cerebellar stem cells and we now plan to model human medulloblastoma development by overexpressing oncogenes or silencing suppressor genes that are defined as clinically relevant medulloblastoma drivers. We will use a forward genetics screen to identify novel drivers and specifiers of various subtypes of medulloblastoma. We hope these combined efforts will help us better model human medulloblastoma formation and we expect to generate tumors that correlate well, both pathologically and molecularly, with primary cell cultures derived from medulloblastoma patients.

Keywords: medulloblastoma,mycn,neural stem cells,cerebellum
PRObes of Gravitational-wave progENITORs (PROGENITOR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-10-01
End date: 2023-09-30
Duration (months): 24.0
Total project cost (EUR): 175572.48
EU funding (EUR): 175572.48
Participants: 1
Project status: SIGNED

Stars initially ten times more massive than our Sun play a vital role in the evolution of the Cosmos. Their death is marked by the sudden collapse of their cores into neutron stars or black holes. Somehow, tight couples of massive black holes in the distant Universe occasionally merge, unleashing powerful gravitational waves that are now regularly being measured. The underlying processes that lead to the formation of these pairs remain shrouded in mystery, entailing an intricate story about the life cycle of their PROGENITORs -- the most massive and evolved stars. This reminded the astrophysical community of huge gaps in our knowledge of key processes governing massive-star evolution, related to binary interactions, mass-loss, and mixing. To mitigate this, we must obtain robust empirical constraints on the multiplicity, configuration, and stellar properties of the direct progenitors of black holes in regions that approach the conditions of the distant Universe: the Wolf-Rayet populations of the Magellanic Clouds. The MSCA fellowship offers an ideal platform for achieving this, relying on my unique skills, data, and tools in massive-star spectroscopy with training in state-of-the-art evolution models of stellar populations that I will receive at the University of Amsterdam. I will exploit brand new multi-epoch, multiwavelength monitoring spectroscopy obtained with the Hubble Space Telescope (HST) and Very Large Telescope (VLT). I will establish the physical and orbital properties of entire populations of Wolf-Rayet stars and binaries in the Magellanic Clouds relying on state-off-the-art tools and novel analysis techniques. I will compute population-synthesis models to constrain the evolutionary paths of gravitational-wave mergers. Through this, I will push our understanding of massive stars and gravitational wave sources throughout the Cosmos to new frontiers.

Keywords: massive stars,magellanic clouds,wolf rayet stars,black holes,binaries,stellar evolution,gravitational waves
Integrated Climate forcing and Air pollution Reduction in Urban Systems (ICARUS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Italy,Spain,Italy,Greece,Greece,Switzerland,Greece,Slovenia,Belgium,Greece,Greece,Czechia,Czechia,Denmark,United Kingdom,United Kingdom
Call: Improving the air quality and reducing the carbon footprint of European cities (H2020-SC5-2015-two-stage, 2015)
Start date: 2016-05-01
End date: 2020-10-31
Duration (months): 54.0
Total project cost (EUR): 6815765.0
EU funding (EUR): 6472015.0
Participants: 21
Project status: CLOSED

ICARUS will develop innovative tools for urban impact assessment in support of air quality and climate change governance in the EU. This will lead to designing and implementing win-win strategies to improve the air quality and reduce the carbon footprint in European cities. An integrated approach will be used for air pollution monitoring and assessment combining ground-based measurements, atmospheric transport and chemical transformation modelling and air pollution indicators derived from satellite, airborne and personal remote sensing. The ICARUS methodology and toolkit will be applied in nine EU cities of variable size, socio-economic condition and history. Technological and non-technological measures and policy options will be analyzed and proposed to the responsible authorities for air pollution and/or climate change at the city level. Based on the advanced monitoring and assessment tools outlined above, a cloud-based solution will be developed to inform citizens of environment-conscious alternatives that may have a positive impact on air quality and carbon footprint and finally on their health and motivate them to adopt alternative behaviours. Agent-based modelling will be used to capture the interactions of population subgroups, industries and service providers in response to the policies considered in the project. Thus, social and cultural factors, socio-economic status (SES) and societal dynamics will be explicitly taken into account to assess overall policy impact. Our findings will be translated into a web-based guidebook for sustainable air pollution and climate change governance in all EU cities. ICARUS will develop a vision of a future green city: a visionary model that will seek to minimize environmental and health impacts. Transition pathways will be drawn that will demonstrate how current cities could be transformed towards cities with close to zero or negative carbon footprint and maximal wellbeing within the next 50 years.

Keywords: life cycle assessment,agent based modeling,remote sensing,data fusion,cost benefit analysis,green smart cities,citizens involvement,socioeconomic dynamics,environmental justice
Phylogenomics, evolution, biogeography and key traits for breeders in yams (Dioscorea, Dioscoreaceae) (Yamnomics)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-09
End date: 2019-01-08
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Biodiversity conservation has become a priority concern for both science and society. Human population growth and resource exploitation have impacted on worldwide species richness, and affecting evolutionary trajectories of species and the stability of ecosystems. The increased focus on understanding biodiversity and its sustainable use have evolved concurrently with the new genomic (next-generation sequencing, NGS) and bioinformatic techniques that have revolutionized the availability of DNA sequence data for comparative biodiversity studies and lead to the emergence of Phylogenomics, in which evolutionary relationships are recovered based on comparative analyses of genome-scale data. The overarching goal of the proposed project, YAMNOMICS, is to elucidate the evolutionary relationships within the highly diverse genus Dioscorea (Dioscoreaceae). The genomic-scale methods proposed in this project constitute the key for this goal and open up opportunities for the researcher and YAMNOMICS participants to generate substantial and long-term career outputs in biodiversity science. Dioscorea contains 600 species distributed in the tropics and with a low representation in temperate regions, and includes crops that feed tens of millions worldwide. Its economic importance is complemented by other species which accumulate secondary steroidal compounds of pharmacological interest. Molecular studies in yams have focused on studying species of agricultural interest.Additionally, Dioscorea constitutes a focus of interest in evolutionary studies due to its high diversity and the enormous distribution range of its lineages. Several studies focused on the phylogeographic patterns at low taxonomic levels for endangered species. Broader molecular approaches have dealt with phylogenetic relationships des, establishing a Cretaceous Laurasian origin. However traditional molecular methods remain insufficient to determine evolutionary relationships among recently derived species.

Keywords: phylogenetics,phylogenomics,biodiversity,evolution,systematics,biogeography,polyploidy
Culture Labs: recipes for social innovation (CultureLabs)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Italy,Greece,Finland,Greece,United Kingdom,United Kingdom
Call: Participatory approaches and social innovation in culture (H2020-SC6-CULT-COOP-2017-two-stage, 2017)
Start date: 2018-04-01
End date: 2021-07-31
Duration (months): 40.0
Total project cost (EUR): 2479974.38
EU funding (EUR): 2479949.38
Participants: 9
Project status: CLOSED

The proposal’s central concept is CultureLabs, an open and evolving ICT-empowered infrastructure which comprises a rich variety of resources including guidelines, methodologies, digital tools, existing community engagement projects, as well as novel ideas and approaches that can facilitate social innovation in culture. The infrastructure is addressed to both institutional stakeholders and community members to make use of existing shared, and in many cases commonly created, resources, according to their missions and needs. Different resources, the “ingredients”, can be combined in various ways to form a “recipe” that describes how to carry out a participatory project to address the needs of a specific target audience. The primary focus will be on approaches that build positive awareness about communities’ own heritage and memories, and engage their members as bearers and producers of culture. CultureLabs’ case studies focus on different immigrants communities (e.g. refugees, second generation immigrants, female immigrants etc). CultureLabs toolkits and infrastructure are reusable and extensible, and its ingredients can be easily combined and adjusted to meet the needs of different stakeholders and target groups. At least 20 concrete recipes will be designed through the collaboration between different stakeholders, including museums, civil organisations, and policy makers. Four of these recipes will be implemented and evaluated as pilots in three different countries. Research outcomes and the empirical evidence gained from the project’s activities, including the recipes’ design and implementation, will be consolidated into general-purpose methodological guidelines and best practices that can be adopted by any stakeholder who wishes to organise participatory approaches to CH with a social impact.

Keywords: participatory approaches,toolkits,recipes,community,grassroots ch,community engagement,social inclusion
Technology, training and knowledge for Early-Warning / Early-Action led policing in fighting Organised Crime and Terrorism (COPKIT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Ireland,Spain,Austria,Ireland,Belgium,Bulgaria,Romania,Greece,Latvia,France,France,France,Netherlands,Denmark,United Kingdom
Call: Technologies for prevention, investigation, and mitigation in the context of fight against crime and terrorism (H2020-SEC-2016-2017-2, 2017)
Start date: 2018-06-01
End date: 2021-09-30
Duration (months): 40.0
Total project cost (EUR): 4986973.75
EU funding (EUR): 4986973.75
Participants: 20
Project status: CLOSED

The COPKIT project addresses the problem of analysing, preventing, investigating and mitigating the use of new information and communication technologies by organised crime and terrorist groups. This question is a key challenge for policy-makers and LEAs due to the complexity of the phenomenon, the quantity of factors and actors involved, and the great set of criminal and terrorist technological activities in support of OC and terrorist actions. It is a clear VUCA world effect (volatility, uncertainty, complexity and ambiguity). EUROPOL who is involved in COPKIT as head of its Advisory Board, in this year’s SOCTA 2017 report "Crime in the Age of Technology" states that "This is now, perhaps, the greatest challenge facing LEAs around the world". COPKIT proposes an intelligence-led Early Warning (EW) / Early Action (EA) system, directly related to the methodological approach used by EUROPOL in SOCTA. “Intelligence-led policing” offers a framework to guide operations, prioritizing needs and optimizing resources. EW explain how crimes are evolving, identifying "weak signals", warnings, new trends, and being a basis for assisting decision makers, both strategic and operational levels, in order to develop EA (preparedness, mitigation, prevention and other security policies). Our project, with 18 European organizations from 13 countries participating (9 of them LEAs from 8 countries, one of them leader of EMPACT firearms) and with EUROPOL leading support, aims to create such a technological intelligence and knowledge ecosystem for LEAs, to fight OCT. COPKIT will comprise several phases: (1) developing and applying a EW/EA system and applying it to use-cases, (2) developing a toolkit for knowledge production and exploitation, tested by LEAs in their premises, (3) ensuring respects to EU legal and ethical principles, (4) developing innovative curricula for all aspects of the EW/EA methodology and eco-system to facilitate the uptake by LEAs.

Keywords: information extraction,knowledge discovery,spatial temporal prediction,knowledge management,deep learning,counter terrorism,early warning,early action,osint,intelligence led decision support