Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Chronic kidney disease and acute kidney injury – evaluation of EU and global epidemiology (CKD AKI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-11-02
Duration (months): 24.0
Total project cost (EUR): 168277.2
EU funding (EUR): 168277.2
Participants: 1
Project status: CLOSED

Chronic kidney disease (CKD) and acute kidney injury (AKI) are widespread in EU and worldwide, and put substantial burden due to disability, mortality, high cost of treatment, and risk for development of cardiovascular diseases (CVD). Both CKD and AKI are projected to grow due to many factors, including general population aging and increase in diabetes prevalence. Evaluating global and EU regional epidemiology of CKD and AKI is extremely important for understanding current trends and future challenges, and revealing differences of kidney disease in diverse populations. The current proposal is aimed to develop a single database and bibliographic web-based tool for collecting available evidence on CKD and AKI epidemiology worldwide; develop and apply bibliographic search strategy to obtain literature sources and extract multiple epidemiologic parameters for CKD, AKI, and their connection to CVD; produce advanced models for CKD and AKI estimates on the global, regional, and country levels; strengthen existing international collaboration in studying CKD and AKI epidemiology; disseminate results to scientific community, public health authorities, and general public; increase future competiveness and prepare ER for tenure-track position in academic institutions in the EU-member states. The proposal assumes inter-disciplinary approach and international cooperation, contains several innovative elements, intended to produce multiple new deliverables, strength EU-based research, provide substantial career development for the researcher. Major issues in the proposal are directly related to consequences of population aging and increasing the burden of chronic diseases, as well as interconnections between acute and chronic diseases. The results are expected to provide important information for public health planning in EU and worldwide for comparing morbidity, mortality, and provision of medical care.

Keywords: chronic kidney disease,acute kidney injury,epidemiology,bibliographic information system,bibliographic search,modelling
Neural mechanisms of cognitive bias and its role in the triggering of the stress response in zebrafish (BIASTRESS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Portugal
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-05-01
End date: 2018-04-30
Duration (months): 24.0
Total project cost (EUR): 160635.6
EU funding (EUR): 160635.6
Participants: 1
Project status: CLOSED

Assessing the stress resilience of optimistic and pessimistic phenotypes is crucial for the study of stress-related mental disorders (SRMD) in humans (e.g., anxiety and depression). However, only by understanding the neural mechanisms of cognitive bias and its role in the triggering of the stress response can these personality traits be meaningfully linked to susceptibility to SRMD. In this way, BIASTRESS will characterize the behavioural and neuroendocrine profiles of “optimistic” and “pessimistic” individuals and will assess if cognitive bias (e.g. pessimistic bias) is mediating the inter-individual variation in the susceptibility to the detrimental effects of stress. Furthermore, genetically manipulations of the neural circuits involved in the cognitive appraisal of stressors will be conducted in order to evaluate its effects on the activation of the stress response. BIASTRESS aims to elucidate this important matter using zebrafish (Danio rerio) as a model. The unique attributes of the zebrafish biological model are being increasingly leveraged by the scientific community to provide critical scientific bases for the development of new clinical tools for the diagnosis and treatment of human diseases. Hence, the multidisciplinary and unique perspective that will be adopted by this project, combining behavioural, neural and physiological sciences, has the potential to provide useful and scientifically-sound information to explain susceptibility to SRMD in humans, which will be extremely useful for developing ways to mitigate the effects of chronic stress. Moreover, this project will also be helpful in the field of antidepressant drug research, since pessimistic and optimistic individuals may diverge in their response to antidepressants. In this way, the goals of BIASTRESS directly address the societal challenge priority of health, demographic change and wellbeing established by the H2020 Work Programme.

Keywords: fish,neuroendocrinology,stress physiology,chronic stress,wellbeing,cognition
City-centered approach to catalyze nature-based solutions through the EU Regenerative Urban Lighthouse for pollution alleviation and regenerative development (Upsurge)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Fighting and adapting to climate change
Action type: Innovation actions
Countries involved: Austria,Germany,Italy,Spain,Spain,Italy,Germany,Italy,Hungary,North Macedonia,Belgium,Greece,Poland,Slovenia,Belgium,Croatia,Netherlands,United Kingdom,United Kingdom
Call: Innovative nature-based solutions for carbon neutral cities and improved air quality (H2020-LC-CLA-2020-2, 2020)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 9703462.5
EU funding (EUR): 9320400.0
Participants: 26
Project status: SIGNED

Air pollution and ambient pollution, carbon-related issues ranging from GHG emissions to carbon shortages in soil, the opportunities provided by NBS and the intricacies of urban ecosystems present an extremely complex set of interdependent problems and opportunities that have to be addressed as such – interactively, mutually and innovatively. Upsurge is considering all these aspects and is providing evidence-based targeted responses that will enable EU cities to transition into a more regenerative future. At its core, Upsurge is presenting the European Regenerative Urban Lighthouse, which will enable cities to unlock their regenerative potential and provide them with knowledge and guidance in regenerative transition. Supported by an innovative continuous self-check progress mechanism (Regenerative Index) and by the Clearing House as a knowledge nerve centre, Upsurge will motivate cities and other clients through its networking activities to engage and step aboard the regenerative transition under Lighthouse’s leadership. Upsurge is demonstrating technical excellence through a multimodal adaptable sensing system, through integrated and integrative digitalisation environment supported by IoT and AI, several real-life demonstrations and based on extrapolated criteria conducted simulative demonstrations showcasing the viability, feasibility and implementability of proposed technical solutions. The knowledge core of Upsurge will be introduced within the quintuple helix verification model bringing together all relevant factors affecting the implementation of NBS and thus regenerative change. Quintuple helix approach will truly enable the assessment and exploration of complementary beneficial effects provided by project solutions.

Keywords: urban regenerative transition,nbs based redevelopment,city centred approach
Investigating eukaryotic replisome dynamics at the single molecule level (SMI REP)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 2
Project status: CLOSED

For cells to reproduce, an accurate duplicate of the genome must be created. This is no small task. The genetic information stored in each cell consists of ~6 billion pairs of nucleobases (base pairs, bp) assembled as a polymer 2 metres long and 2 nanometres in diameter, with the structural form of a double helix. For a mammalian cell to divide, this deoxyribonucleic acid (DNA) must be copied in a time frame on the order of 1 day, or ~70,000bp a second. DNA replication is common to all 3 domains of life, bacteria, archaea and eukarya and is accomplished by a complex of proteins. This proposal brings together a researcher of great proficiency in single molecule methods and multidisciplinary research with the Single Molecule Imaging group at the London Research Institute, one of the world leading centres in DNA replication. Combined, we will build unique instruments and develop single molecule assays to understand the molecular gymnastics of DNA replication in eukaryotes. We will elucidate rates of DNA unwinding by eukaryotic helicases and establish enhancements by association with other proteins. We will also study replisome dynamics by observing synthesis of DNA on custom templates in real time. This will allow detection of replication loops and stalling that may occur. We will also examine the mechanism of lesion bypass. The insight gained is impossible with classical biochemical techniques, as individual replisomes are observed in real time rather than measuring an average of a population. Our methods will reveal heterogeneities and obtain precise quantitative details of the dynamics. Features such as pauses and back slips will enable the study of intermediate states and conformational changes linked to replisome dynamics. This proposal will satisfy academic curiosity of understanding life at the most fundamental level but will also increase our knowledge of the how the cell works and thus becomes the building blocks for disease treatment and cures of the future.

Keywords: single molecule studies of dna replication in eukaryotes
Tuning of 2D materials properties through controlled functionalization with opto-electroactive complexes (Terpy2DMat)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-11-01
End date: 2020-10-03
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Ultrathin two-dimensional nanosheets of layered transition metal dichalcogenides (TMDCs) are the fascinating materials for several applications in electronics, opto-electronics, spintronics, sensing, catalysis, energy storage and conversion, to name a few. The fields have witnessed huge attention world-wide in recent years. In spite of advancement of the 2D materials, there is a lack of proper chemical functionalization. Therefore, apposite functionalization of TMDCs to tune electronic charge and spin properties beyond current systems is extremely crucial. Herein, we propose chemical functionalization of 2D-TMDCs by optical and electroactive functional terpyridyl (tpy) complexes. The functional terpyridyl complexes offer numerous advantages including (i) much more robustness due to strong metal-to-ligand back bonding through [dπ(M)-pπ(L)] as compared to the organic ligands, (ii) versatile coordination modes, (iii) tunable, and reversible redox properties, and (iv) switchable metal-to-ligand charge-transfer (MLCT) band in the visible region. Through this functionalization we will be able to: I-Modify 2D materials properties at different level depending on: (i) The strength of the new interaction between complex and 2D crystal, from soft modification by electrostatic interaction to strong modification by covalent one; and (ii) the degree of functionalization, from low coverage of the 2D crystal to highly packed coverage giving rise to self-assembled monolayers (SAMs) formation. II-Tuning of the 2D crystals properties through the effect of light on the opto-electroactive complexes attached on them. The contribution from light-driven action to the electronic and magnetic properties will be deeply studied by the implementation of functionalized 2D-TMDCs into solid state devices, exploring their potential as logic gates and circuits or spintronic devices.

Keywords: transition metal dichalcogenides,terpyridyl complex,electro active,self assembled monolayers,chemical functionalization,charge transport,opto electronic devices
Application relevant validation of c-Si based tandem solar cell processes with 30 % efficiency target (SiTaSol)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Austria,Germany,Netherlands,Denmark,United Kingdom
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2016-RES-CCS-RIA, 2016)
Start date: 2017-05-01
End date: 2021-01-31
Duration (months): 45.0
Total project cost (EUR): 4298201.25
EU funding (EUR): 4298201.25
Participants: 7
Project status: CLOSED

Crystalline silicon wafer solar cells have been dominating the photovoltaic market so far due to the availability and stability of c-Si and the decades of Si technology development. However, without new ways to improve the conversion efficiencies further significant cost reductions will be difficult and the c-Si technology will not be able to maintain its dominant role. In the SiTaSol project we want to increase conversion efficiencies of c-Si solar cells to 30 % by combining it with III-V top absorbers. Such a tandem solar cell will result in huge savings of land area and material consumption for photovoltaic electricity generation and offers clear advantages compared to today’s products. The III-V/Si tandem cell with an active Si bottom junction with one front and back contact is a drop-in-replacement for today’s Si flat plate terrestrial PV. To make this technology cost competitive, the additional costs for the 2-5 µm Ga(In)AsP epitaxy and processing must remain below 1 €/wafer to enable module costs <0.5 €/Watt-peak. It is the intention of the SiTaSol project to evaluate processes which can meet this challenging cost target and to proof that such a solar cell can be produced in large scale. Key priorities are focused on the development of a new growth reactor with efficient use of the precursor gases, enhanced waste treatment, recycling of metals and low cost preparation of the c-Si growth substrate. High performance devices will be demonstrated in an industrial relevant environment. The project SiTaSol approaches these challenges with a strong industrial perspective and brings together some of the most well-known European partners in the field of Si PV and III-V compound semiconductors. Furthermore SiTaSol will support the competitiveness of the European industry by providing innovative solutions for lowering manufacturing costs of III-V materials which are essential in today’s electronic products including laptops, photonic sensors and light emitting diodes.

Keywords: photovoltaics,si tandem solar cells,hvpe,semiconductor bonding,next generation si cells
Unravelling species barriers of coronaviruses (COV RESTRIC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2019-08-30
Duration (months): 24.0
Total project cost (EUR): 187419.6
EU funding (EUR): 187419.6
Participants: 1
Project status: CLOSED

Human coronaviruses (CoVs) are distributed worldwide and cause a significant percentage of all common colds. Most of these viruses presumably emerged through zoonotic transmission, have adapted to the human host, and are now known to cause mild upper respiratory tract infections. However, the more recent zoonotic transmission of the highly pathogenic Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) have demonstrated the potential of coronaviruses to also cause highly severe human diseases and are associated with a high mortality. The precise mechanisms that allow coronaviruses to jump across species barriers are only poorly understood. "COV RESTRIC" aims to unravel species barriers of coronavirus infections and to uncover basic host cell mechanisms preventing a transmission across different species. We hypothesize that conserved restriction factors exist between different species which limit viral replication and which need to be overcome via viral evasion and adaptation strategies in order to establish a zoonotic infection. These may include the lack or genetic incompatibility of essential viral replication co-factors as well as the presence of antiviral restriction mechanisms. We will use two complementary genetic screening approaches to identify unknown coronavirus restriction factors. Once we have identified possible candidates, we will analyze them for their cross-conservation employing coronaviruses from different species, such as human, bat and camel virus isolates, as well as the respective primary cell culture material originating from the authentic host. This approach will help to rigorously define species barriers to viral transmission which should promote future development of preventive and therapeutic strategies to combat emerging RNA virus infections in humans.

Keywords: coronavirus,species barriers,interferon stimulated genes,viral restriction,cross species transmission
Innovative and Affordable Pick and Place Robots with 10µm high mechanical accuracy and Advanced Computer Vision Algorithms for automatic electronics assembly manufacturing (VisionBot)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Romania
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-03-01
End date: 2017-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Millions of electronic devices remained at the prototype stage and disappeared because the creators didn't afford to buy expensive factory machines or got refused by the Chinese mass-production factories. In the last 2 years, we designed and manufactured 10 units of VisionBot – a breakthrough, affordable electronics assembly robot that can facilitate millions of makers, electrical engineers, students and SMEs to start electronic production in garages. Like 3D printers, Pick and Place robots existed even 30 years ago. But the market has only high-volume machines that are very expensive and prohibitive - cost more than a €100,000 VisionBot was designed to use the mechanical technology from 3D Printers and to be suited for an electronic production line in a "garage" or startup. We want to build and sell affordable midsize €2,500 robots that assembly electronic products by placing ICs, chips, and passives onto circuit boards. Our most disruptive competitive advantage is the Computer Vision Algorithms that process images from two digital microscopes allowing the robot to place with 10µm high precision electronic components in devices, consumer, industrial, medical, IoT, automotive, etc. So far we built 12 units(10 prototypes) and sold 2 VisionBot units to UK and Romania. With the funds we will test the product's market and feasibility by building and selling 20 new VisionBot units. Many breakthrough electronic devices can be created with VisionBot in EU garages. If 3D printers started a revolution in prototyping, VisionBot can start the next technological revolution making electronic production affordable. VisionBot reduces market entry barriers for millions of makers who were struggling to bring their ideas to the world. The expected outcome is the technical and economic validation of the VisionBot machines with market and costs analysis and a detailed step-by-step strategy ready for commercialization across European and international markets Web http://visionbot.net

Keywords: electronics,robots,production,mini factories,assembly,disruptive pick and place robots,computer vision,electronics manufacturing,high accuracy
EEN Northern Netherlands - H2020 SGA4 - Period 2020/21 (H2020 SGA4)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Netherlands,Netherlands
Call: H2020 ENTREPRISE EUROPE NETWORK SGA4 2020-2021 (H2020-EEN-SGA4-2020-2021, 2019)
Start date: 2020-01-01
End date: 2021-12-31
Duration (months): 24.0
Total project cost (EUR): 95471.25
EU funding (EUR): 95437.0
Participants: 7
Project status: CLOSED

H2020 SGA4 - period 2020/2021 This is the plan for the period 2020-2021 of EEN Northern Netherlands for the face to face support of organizations in the provinces of Groningen, Drenthe and Friesland. It describes how we plan to support organizations with KAM and EIMC services in order to help grow the economy. It also describes how synergy is sought with the EEN COSME plan of EEN Northern Netherlands.

Keywords: innovation support,eimc,northern netherlands