Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
A Foundation for Empirical Multimodality Research (FOUNDATIONS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Texts and Concepts
Panel description: Literary studies , literature,  philosophy
Countries involved: Finland
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-05-01
End date: 2029-04-30
Duration (months): 60.0
Total project cost (EUR): 1999974.0
EU funding (EUR): 1999974.0
Participants: 1
Project status: SIGNED

This project lays a foundation for conducting data-driven empirical research on multimodality, that is, how human communication and interaction rely on combinations of 'modes' of expression. Theories of multimodality are rapidly gaining currency in diverse fields concerned with human communication, interaction and cultural production. However, most theories of multimodality are based on conjecture and remain without an empirical foundation due to the lack of large, richly-annotated multimodal corpora and methods for their analysis. FOUNDATIONS solves this problem by developing a novel methodology for conducting empirical research on multimodality in everyday cultural artefacts, such as newspapers, textbooks, magazines and social media videos. This methodology allows critically examining key theoretical concepts in the field – medium, semiotic mode and genre – and their joint contribution to meaning-making, which renews our understanding of key theoretical concepts in multimodality research and places their definitions on a solid empirical foundation. To do so, FOUNDATIONS creates large and reproducible multimodal corpora using microtask crowdsourcing, which breaks complex tasks into piecemeal work and distributes this effort to non-expert workers on online platforms. These crowdsourced descriptions are combined with computational representations into graphs that represent the structure of multimodal discourse. For analysing these corpora, the project develops novel methods based on neuro-symbolic artificial intelligence, which enables combining crowdsourced human insights with the pattern recognition capability of neural networks. The groundbreaking theoretical and methodological advances in FOUNDATIONS go far beyond state of the art by enabling large-scale empirical research while preserving analytical depth needed for multimodality research. This opens up new domains of inquiry for studying multimodality across cultures, situations, artefacts and timescales.

Keywords: multimodality,digital humanities,corpora,crowdsourcing,humanities computing
Revisiting the origin of intrinsic cellular autofluorescence in metabolic imaging (ROICAM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-09-18
End date: 2025-09-17
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: SIGNED

Metabolic dysregulation is a hallmark of numerous diseases. Multiphoton microscopy (MPM) combined with fluorescence lifetime imaging (FLIM) of the metabolic coenzymes NADH and FAD has emerged as a key method for monitoring metabolic processes in live tissue with sub-cellular resolution. However, recent data demonstrates that spectral crosstalk from other cellular components, such as keratin, is substantial. Yet the contributions from endogenous proteins are often neglected, bringing into question the validity of earlier studies. To address this issue, we propose to systematically scrutinize the fluorescence properties of NADH, FAD and keratin in different states and combinations. This will be done by meticulous investigation of the fluorescence lifetime, spectra and related photophysical properties using MPM and time-resolved spectrophotometry under a range of conditions (pH, temperature, viscosity, protein binding), and in combination with computational chemistry. Based on this knowledge, we will develop approaches that can accurately determine the concentration, diffusion and binding state of NADH and FAD even in the presence of spectral crosstalk from keratin. The strategy is to implement phasor-FLIM analysis, fluorescence lifetime correlation spectroscopy (FLCS) and raster lifetime image correlation spectroscopy (RLICS) to separate the fluorescence contributions of bound and unbound NADH and FAD from the protein background and quantify the spatial distribution of each species with unprecedented spatiotemporal resolution. The developed methodologies will be validated by monitoring cellular metabolism in human primary cells and tumour cell lines. This study will solidify our understanding of NADH and FAD autofluorescence in complex cellular environments and substantially expand the analytical toolset by which quantitative information about metabolic dysregulation can be obtained, thereby advancing MPM-FLIM as a research and diagnostic tool for metabolic diseases.

Keywords: flim,multiphoton microscopy,cellular autofluorescence,metabolic imaging
Encouraging a digital and Green transition through Revitalized and Inclusive Union-Employer Negotiations (EGRUiEN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Culture, creativity and inclusive society
Theme: Culture, creativity and inclusive society
Destination: Innovative Research on Social and Economic Transformations
Action type: Research and Innovation actions
Countries involved: Finland,Italy,Austria,Estonia,Norway,Poland,Spain,United Kingdom,Slovakia
Call: Social dialogue in the new world of work (HORIZON-CL2-2024-TRANSFORMATIONS-01, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 2999951.25
EU funding (EUR): 2999951.25
Participants: 11
Project status: SIGNED

The EGRUiEN project aims to answer the question of how best to ensure a just green and digital transition through social dialogue institutions and practices, to protect, represent and include precarious and non-standard workers, and to protect affected workers currently in primary labour market jobs from falling into precarity. Europe is undergoing a period of rapid, fundamental transition, which is affecting production, employment, job design and skill requirements in many industries, such as in the sector cases EGRUiEN investigates, automotive, energy, on-demand transportation/taxi, and care services. This presents contradictory goals: for economic and environmental reasons the transition must occur as quickly as possible, yet this fuels processes of creative destruction that undermines the efficacy of social dialogue. Social dialogue, however, has often been a tool to guide transitions. EGRUiEN will research how past social dialogues have managed similar transitions, and how current social dialogues are faring. Through participatory action research with actual and potential social partners, EGRUiEN will create a research basis to revitalize social dialogue to manage the green and digital transition. This will providing us with research-based tools for more inclusive and effective social dialogue. EGRUiEN has nine work-packages: Management (WP1), history (local longitudinal historical case studies, WP2), four sectoral studies (autos, energy, care, and on-demand transport, WP3-6), EU-level coordination (action research, WP7), New Social Dialogue (cross-country analysis, WP8), and Dissemination (WP9). The historical research provides a basis for the sectoral studies, which provide a basis for EU-level participatory action research (WP7) and cross-national analysis (WP8). Dissemination in is built into the research design through participatory research, but also WP9 enables widespread dissemination among practitioners, policy makers and academics.

Keywords: social dialogue,green and digital transition,precarious workers,
Patent-pending co-fermentation technology that mimics nature to create natural, delicious and nutritious vegan seafood products. (Koralo Vegan Seafood)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Germany
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-08-01
End date: 2024-07-31
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Koralo creates natural, delicious, and nutritious vegan seafood through a patent-pending co-fermentation technology that mimics nature. Starting with a beach walk in the spring of 2021 Koralo was born out of the idea to create a sustainable food source inspired by algae washing up on shore. Sina Albanese, a serial sustainability entrepreneur with the desire to protect our oceanic ecosystems is supported by her father Dr. Guido Albanese with over 25 years of working experience in the food industry in this trans-generational start-up. Koralo mimics with deep-tech the best example we know: Nature. In nature, microalgae are consumed by small fish that are then consumed by larger fish which end up on our plates. At Koralo, we have replaced fish with a unique co-fermentation developed in Germany, where mycelia of edible mushrooms feed on microalgae to create a natural fish alternative product. We have already filed two patent families on this technology and have received positive assessment reports on both our European as well as Global patent applications. We have tested our products with chefs and consumers both in Europe and Asia and are expanding our range to salmon and shellfish such as shrimps and scallops. Koralo is partnering with the largest microalgae producer in Europe in Portugal for scaling up of Koralo's technology with their expertise in microalgae and fermentation and we have successfully reached TRL 5 - 6 on existing equipment. To launch our European production with them we have closed an MoU. Koralo will launch its whole-cut vegan fish in Q1 of 2023 in B2B channels in Korea with further expansion to Singapore, Hong Kong, Europe and the US within the next 5 years. For this end we have closed several MoUs with restaurants and distributors in Korea already. Our biotechnology will allow us to reach price parity with fish already at launch and grow Koralo to a global company with revenues of almost 500 m€ within 5 years having a positive impact.

Keywords: alternative protein sources
Inossia Cement Softener - a new and unique additive to bone cements to revolutionise the treatment of vertebral fractures in osteoporotic patients (SMART-SOFT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-08-01
End date: 2025-07-31
Duration (months): 24.0
Total project cost (EUR): 3283325.25
EU funding (EUR): 2298325.0
Participants: 1
Project status: CLOSED

The Inossia Cement Softener is an additive (a softener) for bone cements that lowers their stiffness by 50-75% and adjusts it to that of the bone it is injected into. This does not alter the spinal biomechanics to the extent that the currently used cements do which in turn reduces the risk of new unnecessary vertebral fractures by 75%. The Inossia Cement Softener has the potential to become a true game-changer and revolutionise the outcome of vertebral augmentation treatments in osteoporotic patients: the patients will experience immediate pain relief, allowing them to go back to everyday life without the risk of rehospitalization, the clinicians will be able to offer an efficient treatment the healthcare payers will save money previously unnecessary spent on the retreatment of already treated patients Our innovation is designed to revolutionise the treatment of osteoporosis, ensuring a healthy and active ageing.

Keywords: vertebral augmentation,osteoporosis,vertebral fractures,bone cement softener
Eco-evolutionary dynamics in plant-soil interactions during land use transition: consequences for soil functioning and resilience to drought (PlantSoilAdapt)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Estonia
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 1999386.0
EU funding (EUR): 1999386.0
Participants: 1
Project status: SIGNED

European grasslands have been shaped by millennia of low-intensity management and are unique cultural and biodiversity hotspots providing critical ecosystem services. However, the area of traditionally-managed grassland has declined dramatically during the last century, with land-use intensification on productive soil and abandonment of unfertile land both causing species loss and deterioration of ecosystem services. Recent evidence suggests that land-use change also leads to genetic and phenotypic changes in plant populations. How population-level processes mediate the impact of land use on ecosystem functions and affect adaptive potential to future perturbations is entirely unknown. Filling this knowledge gap is urgent as grasslands face additional pressure from climate change, particularly an increasing frequency of droughts. I hypothesise that land use intensification and abandonment lead to evolutionary shifts in plant function away from resource conservation towards fast resource acquisition and low stress tolerance. Combined with the disruption of co-evolved mutualistic plant-microbial interactions, this has cascading effects on essential ecosystem services provided by soils and their resilience to drought-induced perturbation. The hypothesis will be tested using laboratory tests of the mechanisms underlying eco-evolutionary dynamics in plant-soil interactions during land-use change and community-level experiments to uncover the consequences of adaptation for soil functioning and resilience to drought. I will use the world's longest-running fertilization experiment and grassland networks in three European regions, representing different histories and contrasting management regimes. The project will provide a step-change in our understanding of the selective pressures imposed on plant-soil systems by human land use and will inform future policies for sustainable land management and maintenance of adaptive potential in the face of climate change.

Keywords: plant microbial interactions,local adaptation,land use,drought resistance,functional traits,ecosystem functioning,grasslands,adaptive potential
Directing Stem Cell Activity through Mechanical Stimulation of Metamaterial 3D Scaffolds (MECCANO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-10-01
End date: 2030-09-30
Duration (months): 60.0
Total project cost (EUR): 3500000.0
EU funding (EUR): 3500000.0
Participants: 1
Project status: SIGNED

Regenerative medicine aims at repairing damaged tissues in our body. To do so, stem cells are often used. My research has been focused on biofabrication innovations for tissue engineering, which aims to direct stem cell fate to steer tissue regeneration. While mechanical loading play a determinant role in the organization of adult cells and tissue development, and my past work with 3D scaffolds demonstrated the importance of mechanical cues to direct stem cell fate, very little is known about its influence on pluripotent stem cells (PSCs). PSCs are a powerful resource for tissue engineering whose application currently suffers from many limitations. One such limitation is the reliance on added biological factors to induce iPSC differentiation, which do not reflect accurately what occurs in vivo. MECCANO aims to establish a new research program that focuses on the systematic understanding of the influence of mechanical loading on tissue development from PSCs in 3D cultures. I will design mechanically active metamaterial scaffolds, which are porous 3D materials that can morph their shape in response to mechanical loading, thus providing defined dynamic stresses and deformations to cells hosted on them. I will then develop a library of mechanical metamaterial scaffolds able to maintain PSCs undifferentiated or to direct their differentiation into the three germ layers of embryological development (ecto-, meso-, endoderm lineages) through mechanical loading. This knowledge will be fed back into a mathematical model to enable the rational design and fabrication of scaffolds for the regeneration of a targeted tissue, here vascularized and conductive cardiac tissue, which has not yet been accomplished and provides a proof of concept. MECCANO will deliver a new paradigm for PSC differentiation, based on the optimization of 3D scaffolds' mechanical and structural properties. This solution holds the potential to generate more targeted, complex products for tissue replacement.

Keywords: biofabrication,additive manufacturing,scaffolds,stem cells,mechanical metamaterials
Rebranding the Patriarchs: The Aramaic Dead Sea Scrolls as the Missing Link in Redefining the Occupational Dimensions of Patriarchs in Early Judaism (REBRAOD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-08-01
End date: 2024-07-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: CLOSED

The project provides a comprehensive picture of the developing depictions of patriarchal figures in mid Second Temple period Jewish sources (ca. 300 - 100 BCE). Instead of the patriarchs being merely the forefathers of Israel, they gain further occupational dimensions and/or existing dimensions become more explicitly formulated. Such occupational dimensions are in earlier sources related to priests, prophets, scribal scholars, and wisdom teachers. This rebranding process of patriarchal literary figures produced various kinds of hybrid figures. The sources cover the ancient versions of Genesis, the Aramaic Dead Sea Scrolls and the Book of Jubilees. The main method used in textual analysis is comparative close reading, but theories of literary growth connected with these works and any text critical evidence of variant literary versions are included. Central part of the methodological conversation is definitions of key concepts and terminology. The scientific novelty of this project placing the Aramaic Dead Sea Scrolls into their proper place in the transmission and reception history of the patriarchal tradition and the focus on occupational agency. Adding this evidence, missing in previous studies, has major repercussions on our understanding of the development and growth of the patriarchal traditions. The project will clarify the early reception of patriarchal figures and how and why the broader, multi occupational, literary depictions of the patriarchs were formed and transmitted. The project provides a significant addition to the study of the mechanisms and motifs of literary transmission and editorial processes. The results are crucial for future studies on sources, transmission processes, and social structures of the wider Mediterranean cultural sphere. Moreover, the project provides a basis for analyzing patriarchal traditions in Judaism, Christianity, and Islam with the full appreciation of the early background, religious dialogue and further innovations.

Keywords: patriarchs,aramaic dead sea scrolls,book of jubilees,genesis,rewriting,reinterpretation,second temple jewish literature,second temple judaism
FLEXIBLE LIGHTWEIGHT MULTI-JUNCTION SOLAR CELLS AND MODULES WITH ENHANCED PERFORMANCE FOR EFFICIENT LIGHT HARVESTING IN OUTER SPACE (JUMP INTO SPACE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Challenges
Action type: EIC actions
Countries involved: Italy,Poland,Germany,France,Portugal
Call: EIC Pathfinder Challenge: In-space solar energy harvesting for innovative space applications (HORIZON-EIC-2023-PATHFINDERCHALLENGES-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 3993001.25
EU funding (EUR): 3993001.25
Participants: 8
Project status: SIGNED

The exponential growth of satellite launches and, in general, of in-orbit activities calls for technological breakthroughs in cost-effective solar energy harvesting technologies for Space deployment. JUMP INTO SPACE envisions a high-efficient, lightweight and flexible, stable and sustainable alternative to currently available photovoltaic systems for in-space energy harvesting, via an unexplored synergetic coupling of groundbreaking concepts. All-perovskite tandem solar cells, based on advanced contact materials and finely tuned perovskite absorbers, will be developed to ensure high efficiency (30% at AM0 targeted here, but capable of overcoming the single-junction Shockley–Queisser limit). The devices will be endowed with a pioneering, lightweight and flexible, multi-purpose photonic substrate, designed and optimized to embody the dual function of environment shielding and light management boost, while being remarkably stable against high-energy radiation and atomic oxygen erosion. The optimized all-perovskite tandem solar cells will be manufactured on the multi-purpose photonic substrates and thoroughly tested to deliver unprecedentedly high specific power and prove their stability for Space operation in low-orbit conditions. JUMP INTO SPACE all-perovskite tandem cells on innovative multi-purpose photonic flexible substrates will be game-changers for the next generation of Space Solar Power, e.g. allowing lightweight stowing in rollable platforms, for powering novel propulsion apparatus for in-space mobility and a wide range of spacecrafts and applications e.g. systems for active debris removal, micro- and cube-sats. They could also be deployed in Space-Based Solar Power plants and, through novel, properly designed transmission technologies, power various in-space applications, such as Moon or Mars human bases, or even provide Earth with continuous energy from space.

Keywords: flexible and rollable high efficient tandem perovskite solar cells and modules,light management,space environment stability,sustainability