Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Development of dual-targeting epigenetic modulators for polypharmacology-based cancer therapy (EpiPolyPharma)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-10-01
End date: 2024-09-30
Duration (months): 24.0
Total project cost (EUR): 183970.08
EU funding (EUR): 183970.08
Participants: 2
Project status: CLOSED

Cancer is a multifactorial disorder involving different genetic and epigenetic alterations. Since epigenetic modifications are brought about by multiple enzymes working synergistically, multitargeting compounds may be particularly effective to acutely interfere with aberrant processes. The simultaneous inhibition of two or more enzymes by a single molecule provides improved therapeutic efficacy compared to single-target inhibitors, along with reduced insurgence of drug resistance. Through this project, I aim at developing novel therapeutics targeting protein (de)methylation and (de)acetylation for application in cancer therapy. I will synthesise and evaluate hybrid molecules inhibiting two enzymes at the same time. I will develop two classes of compounds targeting the Lysine-specific histone demethylase 1A (LSD1) and either Protein arginine N-methyltransferase 5 (PRMT5) or Histone deacetylases 1-2 (HDAC1-2). These enzymes cooperate in different pathways that lead to cancer insurgence and progression, hence dual targeting represents a successful strategy to counteract tumour growth. To achieve the outlined aims, I will employ a multidisciplinary approach requiring the fusion of knowledge and tools from medicinal chemistry, biochemistry, biophysics, molecular and cell biology. Through the employment of cutting-edge synthetic approaches, I will prepare LSD1/PRMT5 and LSD1/HDAC1-2 inhibitors which will be assessed through multiple biochemical and biophysical assays. I will also employ native mass spectrometry to investigate their mode of action in the context of the multi-protein complexes formed by the protein targets. The most promising inhibitors will be evaluated in cellular assays to assess their anticancer properties and their effects on transcriptional regulation. This project will open innovative avenues for personalised therapies and provide additional weapons to overcome drug resistance, along with adding new knowledge on the epigenetic mechanisms of cancer.
Franciscan Observants and the Union of Florence: Crafting Church Unity in Ruthenia and Lithuania in the Second Half of the Fifteenth Century (FOUFCCURL)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Czechia,Poland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-07
End date: 2027-07-06
Duration (months): 24.0
Total project cost (EUR): 191918.16
EU funding (EUR): 191918.16
Participants: 2
Project status: SIGNED

The Union of Florence (1439) has been often depicted as a resounding failure of an ambitious undertaking. However, this portrayal does not hold true in Lithuania and Ruthenia, where it acted as a catalyst for religious dialogue and integration, with the Franciscan Observants as its primary supporters. FOUFCCURL will pursue a comprehensive investigation into the role of the Observant Franciscans, known in Poland and Lithuania as ‘Bernardyni’, in utilising the achievements of the Union of Florence as a distinct and practical strategy for Catholicising Lithuania and Ruthenia. FOUFCCURL aims to uncover how the Observants employed the Union of Florence during the latter half of the fifteenth century, drawing on largely understudied sources beyond the important but over-relied Chronicle of Jan of Komorowo. The project will examine papal bulls, the Cismontane Observant Register, the papal ‘Instructio pro Mariano de Jeziorko’, and other lesser-known Franciscan chronicles. Another goal of the research is to bridge the historiographical gap between Western Medieval Studies and the regional historiographies of East Central Europe concerning the Franciscan Observants. To achieve this FOUFCCURL will synthesise the advanced methodologies and insights developed by Western medievalists with the unique historical contexts and sources of Ruthenia and Lithuania. Thus, the project will help illuminate broader patterns of religious and social integration in Europe. FOUFCCURL will also analyse the spatial distribution of Observant foundations in Lithuania and Ruthenia to identify discernible trends in their foundation patterns and create professional maps illustrating their expansion. FOUFCCURL seeks not only to offer a new understanding of the Union’s ‘second life’ in East Central Europe but also to contribute to wider historiographical debates on social and political integration across religious boundaries, enriching our understanding of cross-faith dynamics in the region and beyond.

Keywords: franciscan order,observant franciscans,the union of florence,religious history,east central europe,grand duchy of lithuania,medieval rus
PROstate Focal THerapy (PROFTH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-01-01
End date: 2025-06-30
Duration (months): 18.0
Total project cost (EUR): 214285.71
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

The PROFTH project aims at developing the robotics and AI technologies to enable focal therapies for prostate cancer (PCa) using the robotic positioned developed during the ERC-PoC PROST. PCa therapy is lagging about 10 years from e.g. kidney and breast therapies, that has shifted from invasive surgery to percutaneous ablation of the tumour. Several trials are acquiring the clinical evidence to support the shift from radical prostatectomy to PCa focal therapy, considering the multifocal aspect of PCa and the need to preserve the surrounding anatomical structures. Key to focal therapies is the ability to accurately and repeatably positioning the ablation device in the PCa area and to achieve the minimal tissue removal that satisfies the safety margins around the tumor and leaves the other structures untouched. The problem of accurately positioning a biopsy needle in the PCa area has been solved by the PROST project, thus we want to build on this capability to set the basis of PCa focal therapy. To achieve this goal, PROFTH will address three main objectives: 1. definition of the joint requirements between clinical needs, capabilities of the current ablation devices and positioning accuracy of PROST; 2. development of the digital twin of the pelvic area to integrate the medical information of the patient; and 3. develop a planning algorithm that will compute the position of the ablation devices in the patient PCa. We will test the developed algorithms with laboratory and ex-vivo experiments using the ablation systems available at the University Hospital of Verona.
Long-range and high-data-rate wireless communication using chirp spread spectrum modulated spintronic oscillators. (LoRaSpin)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-05-01
End date: 2025-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Wireless communication is an indispensable facet of modern society, offering remarkable performance and societal benefits. It promotes vast network coverage, scalability, and the ability to connect multiple devices simultaneously and in easily reconfigurable ways. These advantages have facilitated the growth of many sectors, including the Internet of Things (IoT), wireless sensor networks, telemedicine, and mobile commerce. The wireless communication market is valued at approximately €930B globally. With the continued integration of wireless technology into every aspect of our daily lives, this figure is expected to grow to over €1200B by 2027. There is particularly intense development in long-range wireless communication, where the LoRa communication protocol demonstrates the fastest market expansion thanks to its unique time-shifted chirp spread spectrum (CSS) modulation methods. CSS uses a correlation decoding technique for signal transmission over very long distances, largely immune to the significant reduction of amplitude below the noise level of the receiver. The main weak point of LoRa and other modern long-range wireless communication technologies is the relatively narrow bandwidth and slow chirp rate, which are limited by the physical properties of their CMOS local oscillator. The proposed project, LoRaSpin, will deliver a rapid, energy-efficient, affordable, long-range wireless communication system based on spintronic oscillators. LoRaSpin will combine the high data rates of Wi-Fi and Cellular 5G with the extremely long range of LoRa but without the high cost. The technology developed in LoRaSpin hence delivers a unique combination of high data rate, ultra-long communication range, and low cost that no other technology can match today.
Privileged Mobility and Transnational Conjugality in Islamic countries: reconsidering global power relations from a gender perspective in Southeast Asia and West Africa (PriMCo)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Belgium
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 1
Project status: SIGNED

While attention on privileged mobility has predominantly centered on retirees, tourists, lifestyle migrants or obligatory short-term expatriates, scant consideration has been given to the dynamics of medium- or long-term settlement linked to transnational conjugality. Yet, privileged migrants often marry citizens of the host country, and these migratory and matrimony flows are gendered. Whereas European women tend to form conjugal relationships with African men, European men are predominantly involved with South-East Asian women. How can we comprehend these cartographies of desire? Particularly in Islamic countries, what motivates European men and women to establish permanent residences and families in settings where gender norms significantly differ from their countries of origin? How do they adapt to these normative regimes and in what ways do they challenge power relations within the conjugal experience and their host societies? Furthermore, how do they navigate their positions between the two countries to which they belong? To tackle these issues, the project “Privileged Mobility and Transnational Conjugality in Islamic countries: reconsidering global power relations from gender perspective in Southeast Asia and West Africa” (PriMCo) relies on a comparative case study encompassing the Mauritanian and Malaysian capitals based on anthropological (ethnography), sociological (semi-structured, biographical interviews, focus group) and visual methods (filmmaking). This research critically examines the notion of white privilege, shedding a light on the renegotiation of race, gender, and class relations within intimate and global contexts. In addition, at a societal level, by documenting the experiences of individuals from diverse national, racial, and religious backgrounds who engage in relationships, PriMCo fights against racist prejudice and raises awareness of the existence, diversity and richness of transnational families.

Keywords: transnational conjugality privileged migration mobility gender power relations islamic countries globalization ethnography
Chirality detection enabled by colossal optical anisotropy of 2D layered materials (2Dchiral)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-12-01
End date: 2027-05-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Molecular chirality plays a fundamental role in pharmaceuticals, toxicology, and environmental sciences, as enantiomers of the same molecule can have vastly different biological effects. Current chiroptical detection methods, such as circular dichroism and Raman optical activity, require complex, expensive setups with limited sensitivity, often making real-time and field applications impractical. The 2Dchiral project aims to revolutionize chiral detection by leveraging the colossal optical anisotropy of novel 2D materials to create fiber-based chiroptical probes. These functionalized optical fibers will replace bulky polarization optics, improving compactness and portability together with enhancing detection sensitivity by over 10X while reducing costs by 2 – 5X. Our approach is based on the principle that chiral interactions can be significantly amplified if the illuminating light’s polarization state is tailored to match the symmetry of the target molecule. Instead of using conventional circularly polarized light, we will design custom polarization states via 2D-material-integrated optical fiber probes, ensuring optimal enantiomer-specific signal enhancement. This will enable fast, real-time enantiomeric discrimination in pharmaceuticals, environmental monitoring, and food safety. The potential impact is significant: improved enantioselective drug screening, detection of chiral pollutants, and real-time quality control in food and chemical industries. Through IP protection, commercialization strategies, and industry engagement, 2Dchiral aims to establish a new standard for low-cost, high-precision chiral analysis, democratizing access to advanced optical sensing worldwide.
The Ethics of Stigma (TES)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 217965.12
EU funding (EUR): 217965.12
Participants: 1
Project status: SIGNED

Stigma is a familiar feature of human life – and, often, a clearly objectionable one. Opposition to stigmas that reinforce oppressive norms (for example, racist, sexist, or ableist norms) should be amongst the few uncontroversial starting points for a liberal egalitarian politics. But intuitions are significantly more divided in other cases: is it sometimes permissible to stigmatize unjust behaviour (e.g., employers who pay poverty wages) or to use stigma to help secure important social goods (e.g., a stigma against smoking that promotes public health)? My project will develop an account of the moral risks of stigma that helps to answer these questions. Stigma is undertheorized in philosophy. The literature that does presently exist on the topic largely focuses on the objection that stigmatizers treat others as their inferior – and it typically understands stigma in terms of this complaint. Stigma is theorized as a way of (objectionably) treating someone as less than one’s equal. This project aims to fill the large gaps left by the narrow focus of the current literature. In a word, not all stigmas are wrong to the same degree – and the reasons why they are wrong can vary from context to context. We cannot make progress with the large disagreements that exist about the morality of stigma if we theorize stigma in terms of a single kind of wrong. Instead, we need a broader and disaggregative account of its moral risks. This is what my project will offer. This project builds on my recently published work which has started to correct the lack of attention given to stigma within philosophy – thus demonstrating the substantial potential for the growth of this research programme. Stigma is an issue of vast public concern, as well as the subject of large literatures in the social sciences and psychology. The findings of this project will thus be of great interest to an interdisciplinary and general audience, in addition to a philosophical one.
Decentralized microfluidic in vitro diagnostic patch for pandemic control (DECIPHER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Innovation actions
Countries involved: Belgium,Austria,United States,Germany,Guinea,Congo, The Democratic Republic of the
Call: Pandemic preparedness and response: In vitro diagnostic devices to tackle cross-border health threats (HORIZON-HLTH-2023-TOOL-05, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 7053633.03
EU funding (EUR): 6864578.5
Participants: 11
Project status: SIGNED

In vitro diagnostic (IVD) technologies have revolutionized healthcare, yet remain confined to the laboratories. This traditional approach massively failed to manage viral outbreak during the COVID-19 pandemic because it lacked quick and cost-effective diagnosis. Moreover, an urgent need was evident for bringing quantitative lab-quality diagnosis to the hands of end users (i.e., point-of-care, POC). Despite high expectations from Lab-on-Chip technologies, they failed so far to disrupt the IVD market due to their complexity, high cost, off-chip sample preparation, poor scalability, to mention a few. The DECIPHER consortium aims to revolutionize the POC IVD field by developing innovative microfluidic-based DECIPHER patch capable of both biofluids (self-)sampling via hollow microneedles (HMNs) and immediate analysis of this sample on the very same patch in a completely self-powered manner, producing quantitative result to be read out with a re-purposed glucose meter. Ebola and Lassa viruses are selected as relevant model systems because they are highly contagious with human-to-human transmission, high mortality rate and no vaccine/treatment available, thus having meaningful potential for new pandemic threats. To offer such a genuine sample-to-result quantitative POC solution, the DECIPHER value chain, from lab to market, will cover: (1) investigation of high-throughput manufacturing processes with (2) novel polymers, innovations in the fields of (3) microfluidics, (4) HMNs and (5) quantitative molecular bioassays, (6) DECIPHER patch analytical and clinical validation (both retrospective and prospective), as well as (7) AI-based models, (8) socio-economic/systems analysis and (9) life cycle assessment of DECIPHER patch. This true interdisciplinarity will be represented by highly experienced DECIPHER consortium with partners from 3 universities, 5 research institutes, 1 SME, 1 large company and 1 non-governmental organization from 6 countries.

Keywords: polymers,roll to roll,microfluidics,microneedles,microsampling,in vitro diagnostics,point of care testing,infectious disease diagnosis,socio economic systems,artificial intelligence
Paramagnetic NMR Method Development for a New Materials Age in Battery Research (pNMR-dev)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

Magnetic resonance spectroscopy leverages spin—electronic or nuclear—to reveal information about a system otherwise inaccessible to bulk structural characterisation techniques. As applied to device materials, magnetic resonance offers information about local chemical and magnetic structures—e.g., in energy storage and generation, spintronics, and multiferroics—their defects, degradation and failure mechanisms. From a physics-based understanding of spin interactions, one can derive accurate pictures of chemical structure and directly connect it with material properties. Almost all device materials rely on an intimate network of interacting electron and nuclear spins: redox reactions in battery materials, catalysts and photovoltaics; encoding of information in spintronics; and sensing of magnetic, electric and/or strain fields in multiferroics. The unpaired (paramagnetic) electron spins in these systems, however, limit the application of traditional nuclear magnetic resonance (NMR) spectroscopic methods to study their structures. Through understanding and careful control of the interactions between electron and nuclear spins and their influence on device properties, one can design, develop and optimise materials for device applications. This project will develop novel experimental and theoretical methods in paramagnetic NMR to quantitatively assign spectra and extract a structural model, here, applied to lithium- and sodium-ion battery cathodes. The work packages include: (1) design and implementation of state-of-the-art NMR techniques to probe local material structures; (2) development a revolutionary “NMR Rietveld” software for fitting and refining structural models against spectra; and (3) application of the methods developed in (1) and (2) to investigate an ‘unseen’ system. These projects will ultimately guide the future study of materials using paramagnetic NMR, with wide-ranging benefits for the physics, chemistry and materials science fields.

Keywords: solid state nmr,batteries,computational models,local structure,statistical mechanics,epr