Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
X-Chromosome Inactivation and Plasticity in pre-implantation mouse embryo (XCIP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2007-2-2-ERG, 2007)
Start date: 2008-03-01
End date: 2010-02-28
Duration (months): 24.0
Total project cost (EUR): 30000.0
EU funding (EUR): 30000.0
Participants: 1
Project status: CLOSED

In mammals, one of the two X chromosomes is inactivated in females to enable dosage compensation for X-linked gene products. In mice, the first changes associated with X-inactivation occur during early pre-implantation embryogenesis. At the morula-blastocyst transition, paternal and maternal X chromosomes are differentially reprogrammed in the three cell lineages constitutive of the late blastocyst. In order to characterise the factors and epigenetic marks involved in this reprogramming process, we propose to compare the X chromatin structures in model cell lines derived from blastocysts where the paternal and maternal X chromosomes can be distinguished. To do this, we will analyse chromatin modifications and chromatin compaction using a polymorphic tiling array covering 3,5Mb around the X-inactivation centre – a genomic region on the X chromosome controlling initiation of X-inactivation. We will also study the nuclear organisation of the two X chromosomes using three-dimensional Fluorescence In Situ Hybridisation (3D FISH) techniques. These experiments will be repeated in pre-implantation embryos per se. This project addresses important early developmental decisions in mammalian embryology and should help to characterise the molecular principles involved in epigenetic reprogramming and genome plasticity during early embryogenesis.

Keywords: cell biology,developmental biology,molecular genetics
Combined application of targeted therapy and immunotherapy in chronic myeloid leukaemia (IMMUNOTHERAPY IN CML)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2008-11-03
End date: 2012-11-02
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Chronic myeloid leukaemia (CML) is a disease of the haemopoietic stem cell, arising from a translocation t(9;22)(q34;q11). This translocation gives rise to a Philadelphia chromosome together with a BCR-ABL fusion gene that codes for a fusion protein with greatly enhanced tyrosine kinase activity. CML is a paradigm for the use of immunotherapy as well as being a model disease for the use of molecularly targeted therapies (tyrosine kinase inhibitors-TKI) in malignant disease. In patients with newly diagnosed chronic-phase CML, treatment with TKI results in a high rate of durable complete cytogenetic responses (CcyR), but 15% of patients never achieve a CCyR and a further 15-20% of patients achieve a CCyR but subsequently lose it. Moreover in the majority of patients who do respond well, BCR-ABL transcripts can still be detected in the blood and marrow for many years. These and others lines of evidence suggest that leukaemia stem cells persist in all or almost all patients and could pose a risk for relapse after many years of apparently successful treatment. In this study we propose to exploit this status of ‘minimal residual disease’ achieved with TKI by using a multi-epitope vaccine approach to eliminate all persisting leukaemia. Furthermore, we will investigate if the addition of immunomodulatory agents such as interferon-alpha will further enhance this vaccine-induced immune effect.

Keywords: health sciences,leukaemia,immunotherapy,targeted therapy,immunomodulation
FUSENET - The European Fusion Education Network (FUSENET)

Framework: FP7 — Euratom
Programme: Fusion Energy
Destination: Support Actions
Action type: Coordination and support actions
Countries involved: Netherlands,Netherlands,Austria,Belgium,Belgium,Czechia,Denmark,Finland,France,France,France,Germany,Germany,Germany,Hungary,Hungary,Italy,Poland,Portugal,Bulgaria,Romania,Spain,Switzerland,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Greece
Call:  (FP7-Fusion-2007, 2007)
Start date: 2008-10-01
End date: 2013-09-30
Duration (months): 60.0
Total project cost (EUR): 2478290.8
EU funding (EUR): 2000000.0
Participants: 38
Project status: CLOSED

This aim of the FUSENET project is the establishment of a European Fusion Education Network (FUSENET) for education in fusion science and technology, as part of a comprehensive package of coordination actions, in order to increase, enhance, and broaden fusion training and education activities in Europe. The project consists of eleven focused work packages, with a total proposed budget of 2,000,000 €. The project brings together a broad representation of the European fusion community with 36 participants from 18 countries, of which 22 Universities and 14 Euratom Associations. The project consists of four groups of coordination actions: the establishment and running of the FUSENET network; development of individual learning opportunities and common educational goals; development of educational materials and hands-on experiments; and funding of joint educational activities. The FUSENET project will cover all education levels, from secondary school through Bachelor and Master level, to PhD. The actions of FUSENET build upon the already strongly coordinated European Fusion Research programme, coor-dinated under the European Fusion Development Agreement EFDA. The network will be given a permanent identity by the establishment of the FUSENET Association, which will provide a platform for the coordination of existing actions, the initiation, development and implementation of new EU-wide actions, and for the exchange and dissemination of fusion education information. The envisioned concrete end result of the FUSENET project is an integrated fusion education system in Europe, with strong links between fusion institutes and higher education institutes. Through a central website, the pro-gramme will offer a transparent structure of coherent educational actions, accessible and inviting, in which stu-dents and teachers can easily find their way to a variety of attractive ways to participate in the fusion research programme.

Keywords: nuclear fusion,education,network,science and technology,educational materials
Nanodesigning of Atomic and MolEcular QUAntum Matter (NAME-QUAM)

Framework: FP7 — Cooperation
Programme: Information and Communication Technologies
Destination: Future and emerging technologies
Action type: Collaborative project
Countries involved: Italy,Germany,Switzerland,Austria,Spain,Germany,Poland,Lithuania
Call:  (FP7-ICT-2007-C, 2007)
Start date: 2009-01-01
End date: 2011-12-31
Duration (months): 40.0
Total project cost (EUR): 3230625.0
EU funding (EUR): 2440755.0
Participants: 9
Project status: CLOSED

The Project investigates ultracold atom/molecule quantum matter technology for quantum information computational tasks. Our efforts concentrate on atoms/molecules confined in periodic nanostructures, either externally imposed by optical lattices, or self-generated by atomic/molecular interactions. Parallel quantum processing in periodic nanostructures is expected to lead to significant advances in different areas of quantum information. The Project aims at developing novel techniques for quantum engineering and quantum control of ultracold atoms and molecules confined in the periodic nanostructures. An innovative aspect is the development of appropriate tools for achieving quantum control of strongly correlated many body systems at the nanoscale by exploiting moderate- and long-range quantum mechanical interactions. Strongly correlated interacting systems offer a level of computational power that cannot be reached with traditional qubits based on spin, or hyperfine atomic states. Moderate and long, range interactions will be exploited in few body quantum systems in order to produce fast quantum gates using novel robust qubit and/or qudit concepts and using quantum states with topological order, all of them highly relevant for next generation quantum information implementations. The objectives rely on the nanodesign of atomic/molecular quantum matter at the mesoscopic scale of few-body systems. Generation and detection of multiparticle quantum entanglement, robusteness of non-traditional qubits, quantum memories characterise our investigation. The Project will implement new quantum information technologies by achieving the following breakthroughs: characterizing long range interacting systems for optimal quantum information; realizing individual manipulation integrated in proper algorithms; designing new protected qubits or quantum information processors based on long range interactions; developing techniques for topological quantum computation; creating multi-partimulti-particle entanglement for quantum simulation investigations. At the present stage of the quantum information development our objectives are unique for the optical lattice quantum matter technology. As far as the visionary aspects are concerned, the technological and conceptual advances resulting from the planned investigations on multiparticle entanglement, topological structures and nano-optical engineering may lead to the identification of new directions and alternative approaches towards scalable and miniaturisable quantum information processing.

Keywords: quantum information// atomic and molecular quantum matter// long range interactions // mesoscopic systems
Innovative and Novel First Responders Applications (INFRA)

Framework: FP7 — Cooperation
Programme: Security
Destination: Security systems integration, interconnectivity and Interoperability
Action type: Collaborative project
Countries involved: Ireland,Spain,Greece,United Kingdom,Israel,Netherlands
Call:  (FP7-ICT-SEC-2007-1, 2007)
Start date: 2009-04-01
End date: 2011-03-31
Duration (months): 24.0
Total project cost (EUR): 3809464.91
EU funding (EUR): 2642894.69
Participants: 11
Project status: CLOSED

The objective of project INFRA is to research and develop novel technologies for personal digital support systems as part of an integral, secure emergency management system to support First Responders (FR) in crises occurring in various types of Critical Infrastructures (CI) under all circumstances. Project INFRA will focus on innovation at 2 levels: A. Create an open, standards based interoperability layer that will allow: • Full (voice and data) communication interoperability between all FR teams, their command posts and the CI site control centre • Full interoperability of FR applications in use by the FR teams B. Provide practical and useful novel applications for FR teams, all integrated within the open interoperability layer: • Thermal imaging applications • Video annotation • Advanced fibre optic sensors • Indoor navigation system Both the communications interoperability layer and the FR applications in INFRA are novel and go well beyond the current state of the art for the technology in use by FR teams. Unfortunately, due to historic and organizational reasons, communications and digital personal safety applications are currently fragmented and operate in “islands”, with only very basic cooperation between the different FR teams and the CI control centre; usually in the form of voice communications (sometimes even their voice systems are not compatible with each other). Each type of FR (Police, Fire, and Medical) has their own equipment and their own applications. In a similar manner, there is no standardization of CI sites. So FR teams cannot rely on a standardised environment that is common to all CI sites. This situation is quite typical in Europe and globally. Project INFRA will provide a major step towards a standard, seamless, effective and efficient FR environment, which will ensure interoperability with the CI control centre, will save lives and reduce the financial damages of catastrophic events in CI sites

Keywords: first responders,broadband interoperability,therman imaging,video annotation,visuo-intertial navigation,perosnal digital support devices
World Input-Output Database: Construction and Applications (WIOD)

Framework: FP7 — Cooperation
Programme: Socio-economic sciences and Humanities
Destination: Combining economic, social and environmental objectives in a European perspective
Action type: Collaborative project
Countries involved: Netherlands,European organisations area,Austria,Germany,Germany,United States,Netherlands,Greece,France
Call:  (FP7-SSH-2007-1, 2007)
Start date: 2009-05-01
End date: 2012-04-30
Duration (months): 36.0
Total project cost (EUR): 5601953.93
EU funding (EUR): 3991449.0
Participants: 10
Project status: CLOSED

How has the increase in Chinese exports of textile products affected the employment of low skilled workers in German retail trade? What would be the effects of a change in the European Union’s agricultural policy on global CO2 emissions? Economic and environmental policies are designed at a detailed level of industries and products, while production is characterized by an interdependent structure. Due to globalization, these interdependencies cross borders and the inclusion of trade is more than ever essential. Analyzing policy issues therefore requires an all-encompassing database. Its construction is at the heart of this project and the following three aspects are crucial. • Input-output (IO) tables provide a description of the interdependent production structure. Taking the reach of internationalization into full consideration requires a worldwide set of national IO tables (covering at least 80% of world GDP) that are fully linked through bilateral trade data. • Taking the dynamics of internationalization into account requires a time series (1995-2006) of such linked IO tables, in current and constant international prices. • Taking the effects of internationalization into consideration requires that other relevant information is appended. These so-called satellite accounts include labor data for different skill types, investment flows, and environmental and resources data. The first part of the project constructs such a unique database. The second part of the project applies the database to analyze the international interaction of socio-economic and environmental objectives from a policy perspective. These are applications that use the database by directly employing IO and econometric techniques, and applications that use large-scale models that employ the database. The project builds on several previous, EU-sponsored projects and is carried out by Europe’s leading experts in IO theory, data construction, interindustry models, and policy applications.

Keywords: input-output tables,policy modeling,database,socio-economic and environmental accounts
Processes Influencing Democratic Ownership and Participation (PIDOP)

Framework: FP7 — Cooperation
Programme: Socio-economic sciences and Humanities
Destination: The Citizen in the European Union
Action type: Collaborative project
Countries involved: United Kingdom,Belgium,Czechia,Germany,Italy,Portugal,Sweden,Türkiye,United Kingdom
Call:  (FP7-SSH-2007-1, 2007)
Start date: 2009-05-01
End date: 2012-04-30
Duration (months): 36.0
Total project cost (EUR): 1933585.0
EU funding (EUR): 1499839.0
Participants: 9
Project status: CLOSED

This project will examine the processes which influence democratic ownership and participation in eight European states. It will draw on the disciplines of Politics, Sociology, Social Policy, Psychology and Education to examine macro-level contextual factors (including historical, political, electoral, economic and policy factors), proximal social factors (including familial, educational and media factors) and psychological factors (including motivational, cognitive, attitudinal and identity factors) which facilitate and/or inhibit civic and political engagement and participation. The research will be ground-breaking in incorporating the psychology of the individual citizen within its scope, and it will be distinctive in addressing the psychological processes through which political, societal and social factors have their effects upon citizens’ civic and political engagement and participation. Young people, women, minorities and migrants will be examined as four specific groups at risk of political disengagement. The research will focus on the differences, as well as the overlap, between civic and political engagement, and on both direct and representative participation. An innovative multi-level process model of civic and political engagement and participation will be constructed, which will explain how and why different forms and interpretations of democratic ownership and participation develop or are hampered amongst citizens living in different European countries and contexts, with particular attention being paid to the relevant phenomena at regional, national and EU levels. Appropriate stakeholders at regional, national and EU levels will be involved in all stages of the work, to ensure that the research addresses issues of direct concern to these stakeholders, and to ensure that the policy implications and recommendations which emerge from the research meet the needs of these stakeholders and are disseminated appropriately to them.

Keywords: citizenship,political and civic participation,psychological processes,political institutions
EuroPolis: A deliberative polity-making project (EUROPOLIS)

Framework: FP7 — Cooperation
Programme: Socio-economic sciences and Humanities
Destination: The Citizen in the European Union
Action type: Collaborative project
Countries involved: Italy,United Kingdom,Germany,France,Norway,Spain,Romania,Belgium,Italy
Call:  (FP7-SSH-2007-1, 2007)
Start date: 2008-09-01
End date: 2010-08-31
Duration (months): 24.0
Total project cost (EUR): 1834810.3
EU funding (EUR): 1249909.0
Participants: 10
Project status: CLOSED

EuroPolis explores the forms of democratic deficit that directly affecting EU citizens. We test the hypothesis that citizen involvement in inclusive, informed, and thoughtful deliberation about the EU increases access to politically relevant information, citizens’ political engagement in EU public affairs, perceptions of the legitimacy of EU institutions, a sense of belonging to the EU, and voter turnout in EU parliamentary elections. We draw our hypothesis from the theory of deliberative democracy that suggests that democratic legitimacy rests on open deliberation, and prescribes that citizens should become involved in politics. EuroPolis intends to assess the political outcomes of deliberative democratic practices by experimenting what would happen if EU citizens became substantially more informed about EU institutional arrangements, decision-making processes, and policy issues, as well as more aware of the policy preferences of other EU citizens. Would this make them evaluate EU policy alternatives differently from the way they would with limited information? Would their policy preferences change? Would their electoral choices be more aligned with their policy preferences and be more or less likely to vote in second-order elections? Would their electoral choices change? And if EU citizens had equal opportunity to engage in a thoughtful dialogue with citizens of other EU nationalities to discuss what they expect from their Union, would they identify the interests and problems they share with other EU citizens? Would they develop stronger bonds with fellow EU citizens and feel part of the Union they formally belong to? Would there be an increase in civic engagement? EuroPolis will seek to answer these questions through a carefully designed experiment that will assess how political and social attitudes toward EU issues change as a result of exposure to politically relevant information, and what difference this makes for political participation and voter turnout.

Keywords: european deliberative experiment,public sphere and identity,participation,information and inclusiveness,deliberative polling,democratic deficit
Historical Patterns of Development and Underdevelopment: Origins and Persistence of the Great Divergence (HI-POD)

Framework: FP7 — Cooperation
Programme: Socio-economic sciences and Humanities
Destination: Europe in the world
Action type: Collaborative project
Countries involved: United Kingdom,United Kingdom,Netherlands,Spain,Ireland,Uruguay,Germany
Call:  (FP7-SSH-2007-1, 2007)
Start date: 2008-11-01
End date: 2012-10-31
Duration (months): 48.0
Total project cost (EUR): 1695343.0
EU funding (EUR): 1343507.0
Participants: 7
Project status: CLOSED

Understanding the ‘great’ and ‘little’ divergences between Northwest Europe and the rest of Europe, and between Europe and the rest of the world, implies considerable challenges, both in terms of quantification and analysis. In terms of quantification, the major European challenges are to be found in the pre-1800 period, although much work remains to be done in quantifying post-1800 performance elsewhere. This proposed research project fits very tightly with the objectives of this call. We will be explicitly exploring the “relations between world regions and the factors shaping different development paths in a historical perspective” (Area 8.4.1). We will be explicitly focussing on the experiences of Asia, Africa and Latin America, and will be drawing not only upon European-based scholars but on a Latin American partner to this end (Activity 8.4). In terms of the specific topic addressed, “SSH-2007-4.1.2”, the proposal focuses explicitly on the way in which “development processes have and are being affected by relations between world regions and countries”, and on the links between uneven development and such relationships. The project will indeed look at whether and how uneven development is linked to such relations, both past and present; at “the extent to which historical relationships such as colonial and post-colonial relations affect today’s development paths”; at “the role of urbanisation”; and at “gender and development relations”, to which we will be devoting an entire work package.

Keywords: little divergence,great divergence,economic growth,intercontinental trade,industrial revolution,gender,demography,development,unified growth models