Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
eXperimental Supercritical ElEctrolyser Development (X-SEED)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Spain,Italy,Denmark
Call: Innovative electrolysis cells for hydrogen production (HORIZON-JTI-CLEANH2-2023-1, 2023)
Start date: 2024-01-01
End date: 2027-06-30
Duration (months): 42.0
Total project cost (EUR): 2989495.0
EU funding (EUR): 2989495.0
Participants: 5
Project status: SIGNED

X-SEED aims at developing an innovative alkaline membrane-less electrolyzer that works at supercritical water conditions (>374°C; >220 bar) generating high-quality H2 at pressures over 200 bar. This technology maximizes energetic efficiency, improves circularity, and enhances lifetime, resulting in a more competitive green H2 production. X-SEED validates results at laboratory scale (TRL4) for a single cell and a 5-cell stack. Novel catalysts and electrodes are designed, synthesized, and characterized to ensure high efficiencies. Multiscale modeling and cell design ensure laminar fluid flows, allowing H2 and O2 separation without a membrane. Supercritical conditions and membrane-less configuration reduce the electrochemical work required to generate H2 (as interface resistances across cell components are decreased) and increase system lifetime. This results in an improved voltage and energy efficiency (42 kWh/kg H2), current density (> 3 A/cm2), H2 production rate and robustness (degradation rate < 1%/1000h). X-SEED also integrates circularity and sustainability assessments in decision-making, limiting the use of critical raw materials (below 0.3 mg/W) and using wastewaters both for catalyst production and as a possible electrolyte for the supercritical electrolyser. X-SEED consortium possess extensive technical knowledge and experience in key enabling technologies and areas. These will be utilized to realize multiphysics models of cell and stack (DTU, SNAM, IDN, PMat), manufacture and select the best catalyst and electrodes (LEITAT, PMAT, IDN), and design the cell, the stack, and the test bench to validate the supercritical electrolyzer at a laboratory scale (IDN, PMat, SNAM). In conclusion, X-SEED project's relevance and added value extend beyond the technological dimension: it will accelerate the H2 ecosystem, supporting Europe in meeting climate targets and maintaining its leadership position as a technological developer, producer, and exporter of green energy

Keywords: high pressure green h2,oxygen and hydrogen evolution reactions,catalyst,electrodes,membrane less electrolyser,supercritical conditions,multiphysics modelling,sustainability,circularity
Refugee Political Participation (RPP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: CLOSED

If the 82 million displaced people across the world (UNCHR Global Trends 2020) formed a country, it would be the 20th biggest in the world. But they are not a country. Apart from experiences related to poverty, destitution, insecurity, and violence, refugees experience exclusion from the political community and rights of citizenship. The RPP project’s overall aim is to transform how scholarship and policy conceives of refugees by placing their politics in the centre of the enquiry, and studying how their voices are – and can be – recognised and empowered in a political context. It will be the first interdisciplinary and critical scholarly study of refugee participation bridging work in political science, critical legal studies, and socio-legal studies. This project will bring together Will Jones, a political scientist who has conducted pathbreaking work on algorithmic decision-making and digital identity in the refugee regime, with Thomas Gammeltoft-Hansen, Director of the interdisciplinary Nordic Asylum Law and Data Lab at the University of Copenhagen, to conduct the first systematic study of refugee participation. This ambitious project innovatively combines political science, law, and data science to understand how refugees can and could be included and empowered in the refugee regime as it is transformed by the digital revolution. We propose to conduct the first interdisciplinary and critical scholarly study of refugee participation. This will contribute to scholarship in three key respects. Empirically, it will provide multi-sited knowledge of this important-but-understudied issue. Conceptually, it will move beyond uncritical ‘activist’ or ‘institutional’ approaches by applying rigorously theorised work from political science and law. Methodologically, it will move beyond existing work by pioneering an analytical framework integrating multiple disciplines.

Keywords: asylum,refugees,law,politics,digitisation,participation,empowerment
Next-generation vaccines and diagnostics to prevent livestock reproductive diseases of worldwide impact (REPRODIVAC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Innovation actions
Countries involved: Italy,Switzerland,Spain,United Kingdom,Netherlands,France,Germany
Call: Vaccines and diagnostics for priority animal diseases (HORIZON-CL6-2021-FARM2FORK-01, 2021)
Start date: 2022-09-01
End date: 2027-08-31
Duration (months): 60.0
Total project cost (EUR): 3136283.61
EU funding (EUR): 3125324.24
Participants: 18
Project status: SIGNED

Endemic and zoonotic infectious reproductive diseases of livestock cause major economic losses globally and threaten both food security and public health. REPRODIVAC will develop new and improved vaccines and diagnostic tools required to better control four priority abortifacient diseases: porcine reproductive and respiratory syndrome (PRRS), Q fever, ovine enzootic abortion (OEA), and porcine brucellosis. The consortium spans academia and industry with complementary expertise including structural biology, microbiology, immunology, plant and veterinary sciences. This enables us to address reproductive disorders with an interdisciplinary approach: (1) applying reverse and structural vaccinology to select and design vaccine and diagnostic candidate antigens; (2) exploiting relevant protein expression systems for the production of these antigens; (3) producing rationally attenuated and viral vectored vaccines; and (4) developing a suite of molecular and immunological diagnostic tests, including point-of-care tests (PoC) to discriminate vaccinated from infected animals (DIVA). We will develop a broadly protective PRRSV vaccine, and a serological ELISA that will reliably correlate with PRRSV neutralising antibody titres. We will identify protective subunit vaccine candidates for Q fever and validate a companion serological DIVA test. We will further refine an OEA vaccine for commercialisation and pursue a complementary approach towards a DIVA-compatible next-generation subunit vaccine and serological and molecular DIVA/PoC tests. We will develop live attenuated Brucella suis vaccines and brucellosis diagnostic tests with improved specificity. These new vaccines and diagnostics will be further developed by our industrial partners and made accessible to users. Thereby by using the latest technologies in vaccine and diagnostic development REPRODIVAC will improve animal health and welfare, productivity and sustainability of the livestock sector, as well as human health.

Keywords: porcine reproductive and respiratory syndrome q fever ovine enzootic abortion porcine brucellosis
Efficient, portabLe And Secure orchesTration for reliable servICes (ELASTIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Smart Networks and Services
Action type: Research and Innovation actions
Partnership: SNS (JU-JTI)
Countries involved: Greece,Sweden,Finland,France,Belgium,Serbia,Italy,Spain
Call: Reliable Services and Smart Security (HORIZON-JU-SNS-2023, 2023)
Start date: 2024-03-01
End date: 2027-02-28
Duration (months): 36.0
Total project cost (EUR): 4266768.75
EU funding (EUR): 3999990.51
Participants: 13
Project status: SIGNED

The next generation of wireless communication networks, 6G, is set to revolutionize the scope and potential of networked services by offering ultra-high data rates, ultra-low latency, ultra-reliability, and energy efficiency. However, to fully realize the benefits of 6G, it is crucial to ensure efficient and effective orchestration of its broad range of services and resources. ELASTIC proposes a novel approach to 6G service orchestration that utilizes cutting-edge technologies, including WebAssembly (Wasm), Function-as-a-Service (FaaS), and edge Internet of Things (IoT) orchestration, to enable flexible and efficient serverless deployment of services and functions, dynamic scaling and optimization of service delivery, and collaborative processing of large datasets in a privacy-preserving manner. ELASTIC's approach addresses the critical issue of security in 6G orchestration by leveraging Confidential Computing with Trusted Execution Environments (TEEs), and by implementing security policies and service level agreements provided by verticals in edge cloud-native environments and enclaves. To support the development of this approach, ELASTIC will conduct extensive research on executable isolation, early detection of security vulnerabilities, comparative study of Kubernetes eBPF solutions for observability, and assessment of WASM security properties. ELASTIC will also develop a comprehensive infrastructure that includes an open-source framework and interfaces for cross-platform and portable drivers, low-latency, real-time monitoring of cluster-distributed eBPF/XDP and WASM for security issues, high-speed, secure communication algorithms, distributed state synchronization algorithms, and an observability framework for WebAssembly-based serverless/FaaS workloads in Kubernetes. The impact of the ELASTIC will be materialised within the active contribution of the project to referent open-source projects (Linux, Kubernetes, etc), communities, and standards.

Keywords: wireless networks,6g,service and resource orchestration,wasm,wasi,faas,tee,ebpf,fl
In silico modeling of multi-domain proteins in biological condensates (MMultiDP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: CLOSED

Neurodegenerative disorders are one of the leading causes of disabilities and death in elderly populations worldwide. To this date, no established treatment can either prevent or slow down the progression of these diseases. Their occurrences and progression are strongly correlated with insoluble biological condensates composed of nucleic acids and proteins, where the latter are multi-domain proteins with both folded and disordered domains. The formation and the existence of biological condensates can be described through a combination of density (e.g., liquid-liquid phase separation) and network (percolation) transitions. These phase transitions are highly context-dependent (pH, temperature, etc.) and composition-dependent, i.e., the presence of other biopolymers, where these system variations can either enhance or suppress transitions or have a profound effect on the material properties of condensates formed. Currently, we lack computational approaches that can account for such system variations and predict the phase behavior of biological condensates. In this project, I will develop for the first time a quantitative computational model that will enable scanning a large chemical space, as well as, be temperature-sensitive. Next, I will use this model to identify the role of folded and disordered domains in the formation of condensates for two protein families related to amyotrophic lateral sclerosis, frontotemporal dementia, and autism spectrum disorder through large-scale molecular dynamics simulations. Lastly, I will deliver a microscopic understanding of how certain system variations are linked to neurodegenerative diseases, e.g., pH, the presence of other biopolymers, and changes in protein sequence affect the properties of biological condensates. I will carry out this project in the research group of Prof. Kresten Lindorff-Larsen at the University of Copenhagen (UCPH).

Keywords: multi domain proteins,intrinsically disordered proteins,coarse grained modeling,phase separation
SPATIOMIND SHOP FLOOR TOOLS (SM SHOP-FLOOR TOOLS)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Germany
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

nebumind is a German company founded in 2019 with the vision to use the growing amount of data available in production companies to increase the quality of manufactured products and facilitate the shift toward Industry 4.0 nebumind is the result of the combined experience of its two co-founders Franz and Caroline. They have spent over 13 years working in aerospace manufacturing and have gained an in-depth understanding of production methods, sensor technologies, quality monitoring, and data processing. Before founding nebumind, they jointly built up and managed the Airbus subsidiary InFactory Solutions, developing online sensor systems. During that time, Franz and Caroline sensed that manufacturing quality still had great potential for improvement because is often based on experience and intuition. This gives room for interpretations and results in limited improvements during running production, acceptance of recurring scrap, and flat learning curves. So, they developed Spatiomind, the first software on the market, making quality analyses during manufacturing economical for production companies. Spatiomind’s unique selling point is based on the innovative data search engine, developed internally, which can reduce data/information search by a factor of 1 billion compared to conventional solutions. It enables manufacturers to retrieve quality data very efficiently on any manufactured component, display it in an intuitive 3D visualization for first insights and use it for the implementation of more automated quality control and improvement processes in productions. Spatiomind is suitable for aerospace, automotive and semiconductor’s manufacturing and has raised the interest of industries. It has been validated in pilot with large manufacturing companies, including Airbus, MT Aerospace, Fraunhofer/KUKA, Ariane Group, and Otto Fuchs. Under the WomenTechEU, the company aims to validate the market and improve product development of the three automatic shop-floor tools

Keywords: manufacturing,digital twins,industry4 0
Revival of the Powerhouse: How mitochondrial remodelling controls the energy metabolism of the malaria parasite to enable survival in different hosts (MitoReModel)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Finland
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499408.0
EU funding (EUR): 1499408.0
Participants: 1
Project status: SIGNED

The mitochondrion of the malaria agent Plasmodium falciparum is critical for parasite survival and a confirmed drug target. The dynamic organelle undergoes a Plasmodium-specific membrane remodelling process to adapt to changing metabolic conditions in different hosts. This remarkable transformation is thought to be driven by the arrangement of divergent ATP synthase and respiratory chain complexes into supramolecular assemblies, which shape the internal cristae membranes. However, the structures of both oxidative phosphorylation (OXPHOS) protein complexes and the underlying molecular mechanism are unknown. Having recently pioneered parasite OXPHOS complex structure determination, I will tackle this longstanding enigma by combining state-of-the-art parasitology, high-resolution and in situ structural techniques and functional analysis to reconstruct a stage-resolved molecular model of the parasite’s bioenergetic membrane and reveal the mechanism of membrane remodelling: In Aim 1, we will adapt cutting-edge cultivation methods to unlock structural studies of P. falciparum OXPHOS complexes by generating enough sexual-stage mitochondria to perform electron cryo-tomography and visualize the reorganisation of the inner membrane in situ. In Aim 2, we will develop a stage-resolved molecular model of the P. falciparum inner membrane and reveal its architecture by determining high-resolution cryo-EM structures of both OXPHOS complexes, investigating their membrane-shaping properties and revealing binding mechanisms of investigational cytochrome-b inhibitors to inform antimalarial drug discovery. In Aim 3, we draw on new structural insights to perform functional characterisation in parasites and understand the role of parasite-specific subunits in mitochondrial remodelling, energy conversion and parasite fitness. This integrated approach will deliver novel insights into the plasticity and small-molecule modulation of mitochondrial energy metabolism in malaria parasites.

Keywords: mitochondria,malaria,plasmodium falciparum,mitochondrial remodelling,oxidative phosphorylation,energy metabolism,bioenergetics,small molecule modulation,antimalarial inhibitors,structural biology,cryo em
Commit to Green: Participatory urban greening and renaturing towards climate neutrality and resilience in European cities (Commit2Green/C2G) (Commit2Green)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: Germany,Netherlands,Belgium,Denmark,Spain,Italy,Greece,Poland,Bosnia and Herzegovina,Switzerland
Call: Urban greening and re-naturing for urban regeneration, resilience and climate neutrality (HORIZON-MISS-2023-CLIMA-CITIES-01, 2023)
Start date: 2025-01-01
End date: 2029-06-30
Duration (months): 54.0
Total project cost (EUR): 12268892.5
EU funding (EUR): 11991392.5
Participants: 25
Project status: SIGNED

C2G supports 8 cities to move away from a project-by-project NBS intervention approach towards the development of greening and renaturing strategies that (a) are cross-scalar and participatory (b) inform existing development agendas and policies, and (c) are implemented through demonstrators that create tangible impact on the ground for the local communities and broader ecosystem. This paradigm shift is founded on the operationalisation of Ecosystem Services (ES) in city decision-making at the district and city scale. Specifically, C2G assesses the current supply of ES in cities (e.g. flood and heat risk reduction, recreation) and runs targeted engagement activities to map community vulnerabilities, as perceived by stakeholders themselves. These vulnerabilities translate into key place-based priorities, i.e. the demand for ES. C2G works intensely to bridges this gap between supply and demand using districts as entry points. Considering that citizens experience life and meet their needs in this spatial scale, local greening contributions can significantly improve quality of life. A portfolio of projects is defined in the district scale (zoom-in), while coherence with the broader urban fabric, whether blue, green or grey, is maintained (zoom-out). In this way, C2G achieves cross-scalar ecological connectivity. Ultimately, each city will develop context-specific planning guidelines and nature-inclusion strategies that will be turned into “Design solutions for blue-green-grey infrastructure with biodiversity net-gain”. Demonstrators will apply these solutions with citizens participating along the NBS life cycle, from vulnerability assessments in the early phases through to placemaking activities during implementation. This innovative participation approach ensures that interventions maximise perceived value and minimize trade-off risks (e.g. changes in streetscape uses). Satisfaction assessments shall serve as a validation of the success of the co-design approach.