Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ENHANCING WASTEWATER TREATMENT PROCESSES BY CREATING AN INNOVATIVE TURNKEY SOLUTION FOR MARITIME TRANSPORTATION INDUSTRY (WAIT IT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Finland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-05-01
End date: 2019-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

World’s population is about 7.7 billion. Every human being produces an average of 1.3 kilograms of organic waste every day. Organic waste causes difficult and costly challenges everywhere, where there are drain pipes. For example, cruise ships experience major problems due to organic waste. It builds up in drain pipes causing foul odors and blockages ruining customer experience, and at worst, causing fatal accidents. ProtectPipe Oy is a microbiotechnology company. Our disruptive solution literally eats fat, oil, grease and other organic waste from the drain pipes leaving drain pipes clean increasing their lifespan and minimizing the risk of blockages or other sewer related problems. Our microbial liquid consists of five different kind of non-pathogenic microbial strains, which are all hand-picked and particularly chosen to eat different organic waste. At the moment we have approximately 1000 customers in six different customer segments. In this project we will focus on a substantial and our most potential customer segment: Maritime Transportation Industry (MTI). MTI consists of 4281 active cruise ships, 52183 merchant and 5793 naval vessels. Our comprehensive solution for a single ship costs approximately €100,000. Thus, the market potential of the whole industry is huge. Wastewater treatment processes in the industry are old-fashioned. Therefore, we see that our solution fulfills the needs of our potential industry customers. At this point, we have already conducted a several pilot projects with different cruise ships and naval vessels and achieved amazing results with our product. Many of the pilot projects have already led to permanent relationships with our customers. However, we still have not been able to create a comprehensive, breakthrough solution for our MTI customers. Thus, the purpose of this project is to conduct a feasibility study on enhancing wastewater treatment processes by creating a turnkey solution for maritime transportation industry.

Keywords: wastewater treatment,environmentally friendly,microbial strain
FREEWAY : safely and effortless commute in an urban environment (FREEWAY)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: France
Call: Small business innovation research for Transport (H2020-SMEINST-2-2014, 2014)
Start date: 2015-06-01
End date: 2017-11-30
Duration (months): 30.0
Total project cost (EUR): 2364343.75
EU funding (EUR): 1655040.63
Participants: 1
Project status: CLOSED

It is not a bike, it is not a scooter, it is a lot better, it’s FREEWAY: a new revolutionary means of transportation allowing to safely and effortlessly commute in an urban environment. Protected by a worldwide patent, FREEWAY is a small and clean scooter, on three wheels. FREEWAY is unique since it is very light, 14kg, with 2 front wheels for stability and safety, a back wheel that includes the electric engine, and it is fitted with latest generation batteries. FREEWAY may be folded and unfolded within seconds. When folded, it can be carried along, on its two front wheels like a suitcase. Therefore, FREEWAY may be kept with you at all times and is perfectly suitable for intermodal mobility. FREEWAY is an hybrid type of bike with no equivalent product on the market; nevertheless, its market is already very broad. The most direct competition of FREEWAY comes from electric bikes, with a good market growth rate that should be 9.1% over the 2013-2020 period, to reach a market of 1,9 million in Europe. The main objective of FREEWAY business innovation project is the transfer of a new innovative and competitive solution seizing European transport sector opportunities with the view of providing profitability and growth. The specific objectives will be to provide technological and economic viability of FREEWAY electro mobility concept in order to develop a market strategy ensuring Europe wide market uptake, support growth and self-sufficiency at mid-term and participate to Europe bike industry leadership. In addition, FREEWAY business innovation project will address urban environmental and mobility defies by offering the market with an innovative electric powered vehicle which is more light, more practicable, more safe and secure and more trendy for the users, thus, improving users’ quality of life with an innovation offering a door-to-door environmentally-efficient mobility that will quickly and successfully break into European market.

Keywords: intermodal electromobility in urban areas,ultralight vehicle,new mobility concept clean and affordable,portability,quality of life,healthier environment intermodality,safety,patent protected
TRUst-Enhancing certified Solutions for SEcurity and protection of Citizens’ rights in digital Europe (TRUESSEC.EU)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Coordination and support actions
Countries involved: Spain,Spain,Austria,France,United Kingdom,United Kingdom
Call: Assurance and Certification for Trustworthy and Secure ICT systems, services and components (H2020-DS-LEIT-2016, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 999992.49
EU funding (EUR): 999992.49
Participants: 8
Project status: CLOSED

TRUESSEC.EU is a CSA on certification and labelling of trustworthiness properties from a multidisciplinary SSH-ICT perspective and with emphasis on human rights. The current complexity of ICT products and services makes it difficult to appraise their trustworthiness. Thus, certification becomes a must to restore transparency and trust. TRUESSEC.EU aims at exploring the situation, the barriers, and the benefits of security and privacy labels; engaging stakeholders in the discussions, and issuing recommendations that may foster the adoption and acceptance of labels. With that aim, TRUESSEC.EU works and results are sustained by three pillars: 1) A StakeHolders' Online Platform (SHOP), where associated cluster projects and stakeholders from industry, academia, governments and civil society will gather, participate in debates, get informed, and provide their opinions and feedback on the topics of the project. 2) A series of Support Analysis and Studies (SUPPA) from multidisciplinary perspectives on issues of trustworthiness certification and assurance, to study the situation of trust-enhancing labels, barriers/incentives to industry adoption and consumer acceptance. Information will be gathered from both public sources and the interactions with stakeholders through SHOP. Four different approaches will be applied: -Socio-cultural -Legal & ethical -Technological -Business 3) A set of Recommendations on European Trust-Enhancing Labels (ETEL) dealing with: methodological aspects of certification and assurance, a catalogue of criteria for labels and certifications, and regulatory aspects to foster their adoption, plus a strategic agenda. These recommendations reflect the conclusions obtained from the support analysis and from the stakeholders. The community of stakeholders will nourish, among others, from: (a) members of the consortium partners that are stakeholder networks themselves (DIGICAT, APWG, KTN, AUI), and (b) H2020 RIAs & IAs from the associated cluster.

Keywords: privacy,certification,label,assurance
Nose to Brain Delivery of Antibodies via the Olfactory Region for the Treatment of Multiple Sclerosis Using Novel Multi-functional Biomaterials Combined with a Medical Device (N2B-patch)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Advanced materials
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Germany,Germany,Belgium,Switzerland,Greece,Switzerland,France,Czechia,United Kingdom
Call: Biomaterials for diagnosis and treatment of demyelination disorders of the Central Nervous System (H2020-NMBP-2016-two-stage, 2016)
Start date: 2017-01-01
End date: 2021-06-30
Duration (months): 54.0
Total project cost (EUR): 6472998.75
EU funding (EUR): 5325498.75
Participants: 13
Project status: CLOSED

The overall aim of N2B-patch is the development of a new innovative N2B drug delivery technology based on the synthesis of a biomaterial-based innovative galenic formulation that will be applied with the aid of a novel medical device equipped with a container closure system (CCS) as a hydrogel patch to the nasal olfactory region for the chronic treatment of MS. The galenic formulation will consist of drug loaded biodegradable polymer particles (e.g., chitosan, polylactic-co-glycolic acid, PLGA) embedded into a biodegradable hydrogel matrix (e.g., hyaluronic acid (HA)-based) to be deposited as a patch onto the olfactory region. A pH-sensitive, mucoadhesive particle coating (e.g., chitosan, chitosan derivatives) will ensure an environment-specific adhesion to the olfactory epithelium. This novel technology will largely enhance the controlled and sustainable delivery of drugs and increase the drug bioavailabilty to the CNS. NogoA antagonist NG-101 will be used as an active pharmaceutical ingredient (API). Proof of concept studies and initial clinical data have proven the enormous potential of blocking NogoA for spinal cord remyelation and axonal integrity. However, monoclonal antibodies (mAb) like NG-101, do not sufficiently cross the BBB. The sustainable and controlled release of NG-101 to the CNS will be achieved via the transport of embedded polymer particles to the olfactory epithelium, the subsequent release of API and permeation through the olfactory region, the only part of the nasal epithelium which is in direct contact with the brain. The direct transport route from the nasal cavity to the brain, bypassing the BBB, offers an exciting mode of central nervous system (CNS) drug delivery not only for demyelinating disorders but also for other CNS indications, e.g., stroke, neurodegenerative diseases or tumours. The proposed new innovative N2B drug delivery platform is a practical, safe, and minimally invasive technology. It will be exploited for NG-101 and has the potential to be implemented with other APIs with a low CNS bioavailability.

Keywords: multifunctional particles,hydrogel matrix,galenic development,nose to brain delivery,hyaluronic acid,chitosan,pgla,scale up,numerical simulation
BIOHYBRID AND BIODEGRADABLE NANOVACCINES FOR CANCER IMMUNOTHERAPY (iNANOVAC4CANCER)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Finland
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-01-01
End date: 2020-06-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The innovation of the biohybrid and biodegradable nanovaccines to be taken to proof-of-concept lies in the combination of different parts of the nanovaccine. A biohybrid and biodegradable nanovaccine shows potential to: (i) enhance cancer treatment efficacy; (ii) to be universally applicable to all cancers, regardless of the tumour in question; (iii) prolonging the survival rate of cancer patients; (iv) increase the amount of complete tumor remissions; and (v) boost of tumor-specific immune responses. This will allow in the future towards a personalized patient cancer therapy/treatment. More importantly, the applicability of biohybrid and biodegradable nanovaccines extends beyond the cancer treatment, as it can be applied for other type of diseases.

Keywords: nanomedicine,nanoparticles,nanoplatform,nanovaccine,biodegradable,biocompatible,cancer,immunotherapy
Visualising Engineered Landscapes: an archaeological approach to unlock environmental resilience and sustainability in antiquity (VEiL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-07-20
End date: 2017-09-05
Duration (months): 24.0
Total project cost (EUR): 180277.2
EU funding (EUR): 180277.2
Participants: 1
Project status: CLOSED

Contemporary anthropogenic landscapes were shaped by centuries of human action. Land surveying and division were the first forms of widespread landscape engineering performed by pre-industrial societies. Among those, the most complex was unquestionably the Roman Centuriation, which still characterise the rural landscapes of many European countries. Notwithstanding its impact on modern European land organisation, the principles underlying the design approach used by Roman land commissioners are still largely ambiguous. The proposed project thus aims to illuminate the process of landscape engineering undertaken in antiquity by the Roman surveyors and contribute to the discipline of landscape engineering by injecting a new body of evidence into the debate about past land division and design in order to inform models of sustainable practice for contemporary landscape management. The project integrates archaeological, historical and geospatial information to investigate the forms, impact and endurance of complex engineering on the landscape of Aquileia (Italy), a major city of the Roman Empire. Imprinted with the Roman 'spatial signature', the Aquileian countryside provides an unparalleled opportunity to expand our current understanding and perception of the origins and advances of landscape engineering and its efforts to build sustainable responses to long-term environmental and socio-economic pressures. To achieve its research agenda, this study will develop new methods based on Artificial Intelligence for digitally identifying, collecting, integrating, managing and sharing diverse spatial and archaeological data that are key for the identification of the centurial system elements where they are no longer readily identifiable and will apply a novel approach for defining models of land division application and dynamics in antiquity.

Keywords: land division,centuriation,roman archaeology,remote sensing in archaeology
Enzyme-conjugated DNA nanoswitches for biosensing applications (ENZYME-SWITCHES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-10-01
End date: 2022-09-30
Duration (months): 24.0
Total project cost (EUR): 168369.6
EU funding (EUR): 168369.6
Participants: 2
Project status: CLOSED

WHY: Diagnostic markers detection plays a crucial role in the diagnosis of human disorders. Unfortunately, however, current methods routinely used for the detection of these biomarkers still require sophisticated equipment, washing intensive, reagent-intensive multi-step processes. In attempt to overcome the cited limitations, the development of platforms supporting the sensitive, specific, rapid and easy to use measurement for several diagnostic biomarkers, directly in real samples, is urgently needed. WHAT: ENZYME-SWITCHES is a multidisciplinary and interdisciplinary programme with the principal aim to develop a new generation of enzyme-based biosensors that could prove transformative for diagnostic applications. To achieve this goal, I will join the high specificity and sensitivity of enzymes, and the high programmability and versatility of synthetic responsive DNA nanodevices to develop DNA-conjugated enzymes able to provide sensitive detection of a wide range of diagnostic markers. HOW: This challenging objective will be reached thanks to the multidisciplinary and complementary approach of the outgoing and incoming research groups. I will join the expertise of Prof. Plaxco (outgoing supervisor) in molecular biology, enzymes, biosensor technology, bioengineering device and biophysic with that of Prof. Ricci (incoming supervisor) in the DNA-Nanotechnology field, analytical chemistry and electrochemistry to optimize the proposed new biosensors platform. I have already a promising research profile demonstrated by a strong publication track-record, by several awards received and by fruitful international mobility. Thanks to this MSC Fellowship, I will further strengthen my CV and diversify my scientific knowledge acquiring cutting-edge competences as well as complementary skills, which will boost my scientific independence and my future career.

Keywords: dna nanotechnology,enzymatic biosensors,biosensors,dna sensors,aptamers,electrochemical,sensors,point of care sensors
Decoding the organization and regeneration of locomotor neuronal networks in tetrapods by integrating genomics, systems neuroscience, numerical modeling, and biorobotics (SALAMANDRA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Switzerland,Sweden,Canada
Call: ERC Synergy Grant (ERC-2020-SyG, 2020)
Start date: 2021-09-01
End date: 2027-08-31
Duration (months): 72.0
Total project cost (EUR): 9559650.0
EU funding (EUR): 9559650.0
Participants: 3
Project status: SIGNED

The goals of this project are to decipher how the interplay between central and peripheral mechanisms controls locomotion in four legged animals (tetrapods) and to the delineate the reorganization of motor circuits linked to functional regeneration after spinal cord lesion. We will take advantage of the evolutionarily conserved traits of neural structures in vertebrates to address these two fundamental questions by using salamanders as model organisms. Salamanders are best suited to these aims for two main reasons: First, because they have an anatomically simplified nervous system, which yet possesses the main features of all tetrapods; second, because they have unique regeneration abilities among vertebrates and can functionally repair their spinal cord after full transection. Taking an interdisciplinary approach, we will investigate the dynamic interactions between the nervous system, the body, and its environment before and after spinal cord lesion. We will combine numerical models of locomotor neural circuits, robotics, and advanced functional analyses in genetically modified salamanders in a way that will allow us to test biological data in neuromechanical models (simulations and robots) and, conversely, to validate model-based predictions in animals. Through the concerted and tightly collaborative activities in our laboratories, implementing state of the art assays ranging from the molecular to the organism level, we expect to create a blueprint of tetrapod locomotion control: how appropriate movements are generated in response to various environmental or intrinsic stimuli, and how such function can be recovered after injury. The synergy between our groups of complementary expertise will boost scientific research at multiple levels, not only in the field of neuroscience but also in regeneration research, robotics, and numerical modeling.

Keywords: salamander,locomotion,regeneration,spinal cord,descending pathways,transgenic newts,musculoskeletal system,biorobotics
Magma-Assisted Tectonics: two-phase dynamics of oceanic and continental rifts (RIFT-O-MAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2019-03-01
End date: 2024-08-31
Duration (months): 66.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

There is widespread recognition of the central role of magma at divergent plate boundaries. However in almost all models, magmatism is treated as a by-product and is excluded from the dynamics. A thorough understanding of continental rifts and mid-ocean ridges, which are fundamental to plate tectonics, requires consistent models of magma intrusion into the lithosphere and crust. This is a proposal to develop models in which magmatism is an integral thermal, chemical, and mechanical component, and hence to better understand the basic functioning of plate tectonics. Diverse insight and constraints on divergent boundaries come from decades of careful observation. But lacking adequate models of magmatism, old and new issues remain unresolved. For continents, a comparison of available tectonic force to inherent lithospheric strength indicates that magmatic intrusion is required to weaken plates sufficiently for rifting. For mid-ocean ridges, bathymetric analysis suggests that modest variation in the magma supply may be recorded by crustal emplacement and faulting. These phenomena cannot be understood and modelled in the context of single-phase flow. The proposed work breaks new ground in applying a theory that is innately two-phase; one where interpenetrating liquid and solid continua are governed by conservation of mass, momentum, and energy. This theory will incorporate a viscoelastic-plastic/frictional rheology, modelling rock failure under tensile effective stress. Hence it will allow for dikes that interact consistently with faults. The open-source code will be validated by comparison with measurements of surface deformation/relief, products of seismic tomography, and geochemistry of lavas. In collaboration with distinguished project partners, models will be tailored to investigate the East African Rift System and Juan de Fuca ridge. Outreach will support mathematics in Africa. The proposed research will transform our understanding of magma-assisted tectonics.

Keywords: tectonophysics,geodynamics,magmatism,continental rifting,mid ocean ridges