Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Transformations of STate cApitalism in a poSt coronavIruS world (STASIS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-01-17
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 191852.16
EU funding (EUR): 191852.16
Participants: 1
Project status: SIGNED

States are currently designing new strategies and modalities of intervention in order to adapt to the lasting impacts that the covid-19 Great Lockdown will have on industrial structures, financial systems, global and regional value chains, the nature of business competition, and the world of work. While the forms of reassertion of state authority are likely to be extremely diverse, STASIS focuses in particular on the repositioning of European states with respect to investment from state enterprises, state-owned banks, and state-sponsored investment funds, or what commentators increasingly refer to as ‘state capitalist’ investment. There are concerns that firms impacted by covid-19 may be targeted by 'predatory' state-sponsored investors from beyond Europe, as the crisis is being seized as a strategic opportunity to acquire underpriced assets. STASIS offers an original study of how European states are seeking to regulate state capitalist investment from abroad, in light of the tension between attracting foreign capital and retaining control of critical firms and assets, and as parts of broader attempts to construct new regimes of competition, profitability and growth. It proposes to advance scholarly understandings of the political economy of these investments and regulations, by scrutinising the actors, processes, and multiple forms of contestation they involve within and across economic sectors and European states. It uses mixed methods involving 60 semi-structured interviews with key stakeholders, a close reading of policy documents and public reports, and economic analysis, in order to explore empirically-grounded case studies (a comparison of the regulations implemented by Germany and France, and a comparison of 2 economic sectors: Health & Biotech; Artificial Intelligence & Robotics). The study, grounded in geographical political economy, brings together recent literature on state capitalism, economic geographies of crisis transition, and labour mobilisations.

Keywords: geographical political economy,state capitalism,investment regulation,competition regimes,labour,state power,international political economy,covid 19 crisis,territorialisation of production
4D Skyways (PJ18-W2 4D Skyways)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Austria,Germany,Spain,Ireland,Italy,Australia,Germany,Switzerland,Bulgaria,Croatia,Lithuania,Slovakia,Sweden,Norway,Poland,Belgium,France,France,France,France,France,Czechia,Czechia,Netherlands,Denmark,United Kingdom,Denmark
Call: PJ.18 W2 4D skyways (H2020-SESAR-2019-1, 2019)
Start date: 2019-12-01
End date: 2023-06-30
Duration (months): 43.0
Total project cost (EUR): 39185498.81
EU funding (EUR): 18336854.44
Participants: 38
Project status: SIGNED

The PJ18-W2 4D Skyway project aims to continue the research on Trajectory Management (TM) to enable the deployment of the SESAR Trajectory Based Operations (TBO). PJ18-W2 will deliver mature TM operational improvements to accelerate their deployment and to get the associated benefits and will also work on a longer term on the definition of the consolidated TM solution to drive the coherence and efficiency of the research on TM and on architecture alternatives to address the European ATM fragmentation. In details, PJ18-W2 will: • Prepare the deployment of improvements to the ground trajectory prediction and separation management/ monitoring tools by using aircraft trajectory data, more precise meteo data, improved algorithms and machine learning techniques. This will decrease trajectory uncertainty and thus will reduce ATCO workload and increase airspace capacity. • Prepare the deployment of complex CPDLC clearances sent in advance of the horizontal, vertical and longitudinal trajectory change to enhance the synchronisation of the airborne trajectory with the ground trajectory. Automation will keep the flight crew and the ATCO workload to a low level. It will decrease trajectory uncertainty and increase airspace capacity. • Define the Ground-Ground and Air-Ground TM exchanges between the European ATM actors by consolidating the different initiatives and bridging the gaps. This will drive the current and the future TM research and the ICAO FF-ICE discussions. Also, explore new automation for Trajectory exchanges (big data, machine learning, voice recognition…). • Define a trajectory common service as an alternative architecture for Trajectory exchanges between ground ATM actors compared to the current European ATM fragmented approach to improve its cost effectiveness. PJ18-W2 will work on the definition and validation of operational TM solutions using prototypes and the expertise of European ANSPs, Ground and airborne industries, Research centres and EUROCONTROL.

Keywords: trajectory management,trajectory prediction,cdandr,conflict detection and resolution,ads c epp,complex clearance,cpdlc,atn b1,ff ice,common service,machine learning
Air To Air Automatic Refuelling (A3R)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain,Spain
Call: Small business innovation research for Transport (H2020-SMEINST-1-2015, 2015)
Start date: 2016-02-01
End date: 2016-06-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

In-Flight-Refuelling (IFR) is an important method for extending the range of manned and unmanned aircrafts traveling long distances over areas with no feasible landing or refuelling points. We will focus in the flying boom, the preferred solution in an Airbus, EU, NATO context where we need new mechanisms that add safety through automation. We are MESUREX Aeronautics, an ISO9001:2008 and EN9100:2009 certified company, established in 2006 in Malaga (Spain). Since then, we design, develop and manufacture electronic devices and systems for the Aerospace market and special industrial uses. We specialize in high quality mechanical design, enclosures and embedded developments for critical avionics systems. DEFENSYA, is an innovative technological company founded in July 2001, with headquarters in Madrid, Spain, and commercial offices in Puerto Rico (US) and Bogotá (Colombia). They specialise in Aerospace consultancy and engineering services, a sector where they offer their customers’ services in the field of electronics and communications embedded systems, and particularly Vision Systems for Avionics where their experts hold an impressive patents record. Our proposal A3R – Automatic Air-2-Air Refuelling System, intends to: (1) Develop a semi-automatic solution to improve the flying-boom in-flight refuelling (2) Process (patent pending) (3) Develop a new augmented reality haptic user interface that will provide the boomer a more natural and intuitive mean to operate the boom (patent pending). (4) Develop a fully automatic solution to improve the flying-boom in-flight refuelling process (patent pending). A3R will allow MESUREX Aeronautics leading of automatic in-flight refuelling systems segment, a most demanded solution that will let us make ~€102 million sales with expected RoI of 2.19 within 1st 4 years of business based on our preliminary approach to main customers: Boeing and Airbus

Keywords: aircrafts,refuelling,in flight,automation,safety
BreAking the Link betweeN myo10 and CancEr (BALaNCE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Finland
Call: ERC Proof of Concept Grant (ERC-2014-PoC, 2014)
Start date: 2015-05-01
End date: 2016-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Breast cancer is the most frequently diagnosed cancer form and the leading cause of death among women while pancreatic cancer is the fourth commonest cause of cancer-related mortality across the world and very difficult to treat due to its aggressive nature and the relative lack of curative options. A major impediment in the identification of new therapeutic targets lies in our limited understanding of the exact mechanisms taking place within the tumor microenvironment that are responsible for the development of cancer, progression and metastasis. Based on our recent experiments, we have found that high expression of an actin-binding protein correlates with poor clinical prognosis in breast and pancreatic cancer patients. Drawing upon our recent findings, the target of the PoC project is two-fold. First, to (i) validate the clinical application of our novel therapeutic concept by conducting a series of in-vitro and in-vivo tests on a set of 22 Myo10 inhibitory lead-compounds (i.e. “hits”) which were identified via High-Throughput Screening (HTS). Second, to (ii) take the necessary steps towards the definition of the best business path in view of the strong pre-commercialization potential.

Keywords: novel therapeutic concept,myo10,breast cancer,pancreatic cancer
promoting Research Excellence in NAture-based soluTions for innovation, sUstainable economic GRowth and human wEll-being in Malta (RENATURE)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Ireland,Italy,Malta,Bulgaria,United Kingdom,United Kingdom
Call: Twinning (H2020-WIDESPREAD-05-2017-Twinning, 2017)
Start date: 2018-09-01
End date: 2021-08-31
Duration (months): 36.0
Total project cost (EUR): 995905.0
EU funding (EUR): 995885.0
Participants: 6
Project status: CLOSED

The RENATURE proposal aims to establish and implement a strategy and research cluster to step-up and stimulate scientific excellence and innovation capacity in the area of nature-based solutions for sustainable development. Nature-based solutions, defined as living solutions that address societal challenges in a resource-efficient and adaptable manner and to provide simultaneously economic, social, and environmental benefits, are a priority for the key priority for the European Union research and innovation agenda. RENATURE will establish twinning between the Malta College of Arts, Science and Technology (MCAST), as a tertiary and research organisation from a Widening country, and internationally leading research institutions from other member states. The proposed activities include various types of training and networking events aimed at building up the research capacity and at promoting research excellence in the field of nature-based solutions. The research team is composed of three leading research intensive institutions within this rapidly developing field and one private entity; that is the Trinity College Dublin (Ireland); University of Trento (Italy); University of East Anglia (United Kingdom), and Pensoft Publishers (Bulgaria). The project team possesses multidisciplinary skills and complementary knowledge, which is considered as being critical to offer new nature-based solutions for sustainable development. This collaboration is expected to offer the widening institution MCAST an opportunity to increase the research capacity within this sector, link up with existing initiatives and projects led by, or receiving input from, the research-intensive institutions, develop a national research cluster with strong international collaborations, and provide practical solutions based on cutting-edge science and developed through international collaboration.

Keywords: nature based solutions,ecosystem services,landscape ecology,urban ecology,sustainable development
Qur'anic Commentary: An Integrative Paradigm (QuCIP)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Germany,United Kingdom,United Kingdom
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-10-01
End date: 2025-03-31
Duration (months): 78.0
Total project cost (EUR): 1777962.0
EU funding (EUR): 1740135.75
Participants: 3
Project status: SIGNED

QuCIP will deliver the first historical-critical commentary on a sizable portion of the Qur’an in English, covering the three longest and most complex compositions in the Islamic scripture, surahs 2–4, as well as the short opening surah 1. The project will thereby put forward a pioneering proof of concept for an integrative exegetical approach capable of addressing three core dimensions of the Qur’an: the compositional structure of Qur’anic texts, the intricate processes of literary growth and redactional expansion by which many of them have been shaped, and the theological concerns governing the Qur’an’s appropriation of antecedent (especially Jewish and Christian) ideas, traditions, and literary forms. Pre-modern Islamic exegesis will be critically scrutinised as a valuable repository of close scriptural reading, even if its premises and conclusions are not always persuasive to a modern historian. The result will be a paradigmatic benchmark transforming the methodological toolkit of the discipline. In realising this ambitious project, the PI will be supported by three postdoctoral scholars. Two of them will undertake foundational research into the Qur'an's compositional grammar and into Qur’anic law. The third postdoctoral researcher will support the PI’s engagement with the voluminous Islamic exegetical literature and write a reception history of surah 4. The project team will furthermore produce an edited volume or special journal issue.

Keywords: qur an,islam,scripture
Innovative Therapeutic Strategies for Mixed Lineage Leukemia-rearranged B-cell Acute Lymphoblastic Leukemia (InTheMLLrBALL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 158121.6
EU funding (EUR): 158121.6
Participants: 1
Project status: CLOSED

B-cell acute lymphoblastic leukemia (B-ALL) is the commonest cancer in children and B-ALL with mixed-lineage leukemia rearrangements (MLLr) has a particularly dismal prognosis compared with other B-ALLs. Many MLLrB-ALL patients are refractory to chemotherapy and eventually relapse. Thus, MLLrB-ALL remains clinically challenging. Adoptive transfer of T cells engineered to express artificial chimeric antigen (Ag) receptors (CARs) targeting tumor cell surface-specific Ag is an exciting new approach for cancer immunotherapy. Clinical trials in patients with advanced B-ALL treated with CAR-T cells against CD19 have shown impressive disease remission; however relapse still occurs with loss of CD19. Importantly, the B-ALL patients who have not responded to CD19 CAR-T cells were mainly those carrying MLLr. A strategy to offset tumor Ag-loss relapse is to modify T cells with one CAR molecule containing two different binding domains in tandem (bispecific CAR). By using both in vitro and in vivo approaches, I plan to improve CD19 CAR-T cell therapy for MLLrB-ALL by i)developing a novel bispecific CD19/NG2 CAR, which we expect will reduce single-Ag immune pressure, and ii)through the combination of CD19 CAR-T cell therapy with P-D1/PD-L1 blockade. How to achieve a long-term persistence of CAR-T cells in the host still remains a major challenge in adoptive T cell immunotherapy, and therefore understanding the interplay between T cells, MLLrB-ALL blasts and mesenchymal stromal cells/stroma is fundamental to improve the efficiency of this immunotherapy. We will thus address in vitro and in vivo the contribution of the leukemia microenvironment to CAR-T cell efficacy, as a potential tumor microenvironment (PD1/PD1L)-mediated indirect mechanism of immune escape to CAR T-cells. This cutting-edge proposal will increase my scientific potential and I will be benefited with the complementary/leadership training activities already planned to reach in a near future an independent position.

Keywords: leukemia,immunotherapy,car t cells
Ingenious Science shops to promote Participatory Innovation, Research and Equity in Science. (InSPIRES)

Framework: Horizon 2020 — Science with and for Society
Programme: Integrate society in science and innovation issues, policies and activities in order to integrate citizens' interests and values and to increase the quality, relevance, social acceptability and sustainability of research and innovation outcomes in various fields of activity from social innovation to areas such as biotechnology and nanotechnology
Action type: Research and Innovation actions
Countries involved: Italy,Spain,Tunisia,Bolivia, Plurinational State of,Hungary,France,Netherlands
Call: Participatory research and innovation via Science Shops (H2020-SwafS-2016-1, 2016)
Start date: 2017-04-01
End date: 2021-06-30
Duration (months): 51.0
Total project cost (EUR): 2995606.25
EU funding (EUR): 2995606.25
Participants: 9
Project status: CLOSED

InSPIRES brings together practitioners and experts from across and beyond Europe to co-design, jointly pilot, implement and roll out innovative models for Science Shops (SS). The InSPIRES models integrate Responsible Research and Innovation, Open Science and Impact Evaluation as part of their DNA in order to open the research process up in a more strategic way to civil society and other stakeholders. The inputs from systematic impact evaluation studies will be continuously integrated in order to make InSPIRES SS 2.0 models more accurate and responsive to civil society needs and concerns. Concentrating most of its efforts on Research & Innovation in the health sector, with a strong focus on the environmental and social determinants, and giving special attention to gender parity and vulnerable groups (women, the elderly, adolescents, migrants and refugees), InSPIRES brings Science Cafés and other public engagement initiatives into its models together with a “glocal” international focus, for more inclusive, context relevant and culturally adapted community-based participatory research and innovation. Building on a comprehensive communication plan, with a strong effort dedicated to the development and implementation of a sustainability strategy, InSPIRES outcomes will: a) give evidence and support political bodies and decision-makers, in order to propose changes in local, regional, national and international policies; b) nurture the debate about the place and role of society in science, encouraging the systematic and ethical involvement of civil society actors and their societal concerns in the research and innovation processes, and c) support the development of new Responsible Research and Innovation (RRI) and Open Science (OSc) strategies and guidelines, in the context of safe spaces to involve and engage civil society in the whole science process.

Keywords: science shops,community based participatory research,global health,migration,research action,citizen science,social innovation,social cohesion,sustainability
naX2ceLL: AN ADVANCED TOOL FOR ENGINEERING SIMULATION, TAKING NASTRAN RESULTS TO EXCEL CELLS (nax2ceLL)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Spain
Call: Small business innovation research for Transport and Smart Cities Mobility (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-07-01
End date: 2016-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Simulation Analysis is a powerful tool that helps engineers to analyze and predict product performance minimizing the need for building costly prototypes. This allows companies to become more competitive on a global scale while mitigating the risks associated with cost-effectively bringing products to market. In Aerospace Industry, where European companies are globally challenged, the Simulation Analysis is usually conducted by using the NASTRAN Finite Element solver. The results must be read and transformed into another useful format that allows later Post-Processing work, where simulations are repeated for the same parts due to changes in boundary conditions, dimensions and designs. Currently engineers read NASTRAN results from text format by using commercial Post-Processors or “handmade” solutions. Afterwards they have to transform and export manually to Excel sheets for further calculations, entailing tedious and time-consuming tasks, unnecessary additional costs, and human bias. The project naX2ceLL proposes a solution to these inefficient and costly methods. IDAERO aims at delivering an innovative software, naX2ceLL, able to read directly from NASTRAN binary files and transform and put automatically the results by mean of useful and powerful functions in MS Excel cells. naX2ceLL also adds a unique 3D function that allows inserting post-processed Simulation Models into Adobe pdf reports and consulting and managing them without the need to open an external postprocessor. These unique features allow reducing the Post- Processing work (representing 40% of time consuming), up to 50%, which is translated into huge savings (M€ order) when developing a new aircraft (ca. 5-6 years). In Phase 1 we will assess the technical, economic and legal viability of the project through a Business case: testing functions of the software with real end users, and conduct Market Studies, Business Plan, Risk assessment, etc., to pave the way for reaching TRL9 in later Phase 2

Keywords: aerospace industry,simulation analyses,nastran software,binary files reading,finite elements,calculation post processing,prototyping efficiency,automation,3d visualization,business case