Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Probing local ROS distributions in Calcium signaling microdomains after myocardial infarction (MICROS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-07-18
End date: 2019-07-17
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

An increasing number of people suffer cardiovascular diseases and experience myocardial infarction (MI). The subsequent heart remodeling is characterized by weaker contractility, hypertrophy and lethal arrhythmias. The poorly-understood underlying mechanism is related to calcium (Ca2+) mishandling in cardiomyocytes and oxidative stress. To date, most of the studies described global cellular processes and were unable to propose efficient therapies. This work will decipher the structural and functional local organization of reactive oxygen species (ROS) at Ca2+ signaling microdomains: at the vicinity of ryanodine receptors (RyR). Our knowledge is drastically hampered by the lack of local, quantitative and time-resolved ROS probes. We will thus combine the host laboratory competence in cardiac signaling and physiology, and the applicant expertise in ROS luminescent probes in order to quantify the RyR signaling domains remodeling through: (1) the measurement of local ROS production dynamics by NOX2 complexes, and (2) the imaging of the structural remodeling of the microdomains. This research will propose specific molecular targets to better diagnose and potentially reverse heart remodeling after infarction, contributing thus to solve a major public health issue in Europe. The experienced researcher (ER) will gain new technical and conceptual skills in physiology which will reinforce her multi-disciplinary profile and qualify her to lead, in a close future, her independent research activity.

Keywords: ros signaling,ca signaling,myocardial infraction,luminescent nanoprobe
Disruptive technology for cost-effective and reliable Floating Wind (X1 Wind)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

X1 Wind is developing a disruptive floating wind system with the potential to make a step change in the sector. Europe’s best wind energy resources are located offshore in deep waters with an estimated potential of 4.000GW. This is why the European Commission has identified the development of floating substructures for deeper waters as one of the key strategic targets in the SET-Plan Declaration. However there are several challenges to be overcome, mainly related to the need to reduce its costs: current solutions use “marinized” traditional turbines mounted on the top of existing Oil&Gas platforms resulting in very heavy structures and requiring large and expensive vessels to be installed. Unlike other floating designs, X1 Wind has redesigned an integrated solution which takes advantage of its floatability instead of working against it. By using a downwind configuration and a single point mooring system, we allow the floating platforms to weathervane, self-orientating itself with the wind. By doing this we can remove the active yaw system, the ballast system and the tower which are no longer required, reducing the platform weight by 80% and the maintenance required. The impact is a 50% reduction of the cost of energy. The concept is the result of more than 20 years of combined experience and learning of its founding team in offshore renewables, who have worked in some of the leading companies in the sector. Since its creation in 2017, this innovative SME has received international recognition with the Cleantech Camp prize and the selection into Singularity University Incubator’s program (in NASA Ames research Centre in Silicon Valley). We have also received letters of interest of two leading European utilities (Gas Natural Fenosa and EDP Renewables) and turbine manufacturer Alstom Wind / GE and we are collaborating with of the most experienced R&D centre in the sector (WavEC, Plocan and DTU) to bring our technology to the market.

Keywords: offshore wind,floating wind,cost reduction,enhanced performance,easier installation,improved reliability,clean energy for islands
Development and Validation of an Innovative Solar Compact Selective-Water-Sorbent-Based Heating System (SWS-HEATING)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Low-cost, low-carbon energy supply
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Italy,Italy,Germany,Germany,Sweden,Greece,Russian Federation,Sweden,Greece,United Kingdom,United Kingdom,United Kingdom
Call: Developing the next generation technologies of renewable electricity and heating/cooling (H2020-LCE-2017-RES-RIA-TwoStage, 2017)
Start date: 2018-06-01
End date: 2023-11-30
Duration (months): 66.0
Total project cost (EUR): 5236488.75
EU funding (EUR): 4994926.25
Participants: 16
Project status: SIGNED

The SWS-HEATING project will develop an innovative seasonal thermal energy storage (STES) unit with a novel storage material and creative configuration, i.e. a sorbent material embedded in a compact multi-modular sorption STES unit. This will allow to store and shift the harvested solar energy available abundantly during the summer to the less sunny and colder winter period thus covering a large fraction of heating and domestic hot water demand in buildings. The targeted benefit of this next generation solar heating technology is to reach and overcome a solar fraction of 60% in central/north Europe, reaching 80% in the sunnier south of Europe, with a compact and high-performing STES system at low cost, realising solar-active houses throughout EU. The SWS-heating system is based on a multi-modular sorption seasonal thermal energy storage (STES) unit, using novel sorbent materials of Selective Water Sorbents (SWS) family characterised by superior heat storage density compared to the state of the art, making it possible to drastically decrease the storage volume with negligible thermal losses. These materials are employed in a sorption module with dedicated heat exchangers. Solar heat is provided to the storage modules by high-efficiency evacuated tube solar thermal collectors. Intensive research activities will deal with an advanced vacuum combi-storage tank, with the aim to further minimise thermal losses. A smart and adaptive control will be developed for efficiently managing heat supply and demand sides, including advanced features aiming at user-friendliness. A building prototype will be commissioned including the SWS-heating system, which will be tested and validated in Germany and Sweden and proof all challenging objectives. The project also includes dissemination and communication activities to ensure outreach of its results. Moreover, exploitation activities include long-term deployment path development through a technology roadmap.

Keywords: sorbent material,multi modular sorption seasonal storage unit,heat exchangers,solar collectors,heating,compact,solar active house
DIGITAL-WATER.city - Leading urban water management to its digital future (DWC)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Theme: Protection of the environment, sustainable management of natural resources, water , biodiversity and ecosystems
Action type: Innovation actions
Countries involved: Italy,Italy,Germany,Spain,Germany,Spain,Italy,Spain,Israel,Bulgaria,Norway,Norway,Belgium,France,France,Netherlands,Denmark,Denmark
Call: Digital solutions for water: linking the physical and digital world for water solutions (H2020-SC5-2018-2, 2018)
Start date: 2019-06-01
End date: 2022-11-30
Duration (months): 42.0
Total project cost (EUR): 5897782.7
EU funding (EUR): 4997161.66
Participants: 28
Project status: CLOSED

digital-water.city’s (DWC) main goal is to boost the integrated management of waters systems in five major European urban and peri-urban areas, Berlin, Milan, Copenhagen, Paris and Sofia, by leveraging the potential of data and smart digital technologies. DWC will create linkages between the digital and the physical worlds by developing and demonstrating 18 advanced digital solutions to address current and future water-related challenges; namely the protection of human health, the increase of performance and return on investment of water infrastructures and the involvement of citizens in urban water management. Areas of application of DWC digital solutions range from groundwater management, sewer maintenance and operation, wastewater treatment and reuse to urban bathing water management. DWC combines cutting-edge digital technologies such as augmented reality, open source software, cloud computing, real-time sensors, artificial intelligence, predictive analytics and decision support systems. DWC integrates the development of digital solutions in a dedicated guiding protocol to cover the existing gaps regarding ICT governance, interoperability, ontology and cybersecurity. Ultimately, DWC will provide an interoperable free flow of information among stakeholders and across the water value chain. DWC will generate the necessary conditions for co-creation and open innovation by the establishment of Community of Practices aiming at integrating stakeholder knowledge, ensuring the transferability of the digital solutions in other European or international contexts, supporting knowledge transfer beyond DWC and creating durable binding between European cities. The large scale assessment and communication of the benefits provided by the digital solutions in five major cities will serve as lighthouse, raising the awareness of European cities for a necessary digital transformation, and opening new market opportunities for DWC partners and European providers of digital solutions.

Keywords: urban water systems
Alpha-synuclein and mitochondrial dysfunction: key links between Gaucher’s disease and Parkinson’s? (MitSyn)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-04-13
End date: 2017-04-12
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Recent studies have highlighted a strong genetic association between Parkinson’s disease (PD) and Gaucher’s disease (GD), a lysosomal storage disorder that causes severe neurodegeneration in children and shares some pathophysiological features of PD. GD results from mutations that reduce activity of the enzyme glucocerebrosidase (GCase), causing impaired lysosomal function. It was recently shown that GCase mutations cause several defects associated with impaired cellular quality control - impaired autophagy, mitochondrial dysfunction and accumulation of oligomeric alpha-synuclein, a protein strongly involved in sporadic and genetic PD forms. In fact, alpha-synuclein aggregates are the main constituent of Lewy Bodies, characteristic proteins inclusions found in parkinsonian brains. While PD shows similar features and involves defects in the same pathways, it remains unclear how these diverse findings relate to each other. In the present study we propose to identify the specific interactions between intracellular signaling pathways, cellular quality control pathways and alpha-synuclein oligomerization in an attempt to generate a unifying hypothesis that brings together known features of GD and PD pathophysiology. We will use primary neuronal cultures from gba knockout mice and inducible pluripotent stem cells derived from the GD mouse model and from patients, in which alpha-synuclein will be overexpressed or silenced. Mitochondrial (dys)function, impaired clearance mechanisms and alpha-synuclein oligomerization will be quantitatively characterized in these models by means of an array of biochemical, biophysical and advanced imaging techniques. The results of the work will give us further insights into PD molecular mechanisms and may provide new therapeutic targets.

Keywords: parkinson s disease gaucher s disease alpha synuclein mitochondria live imaging autophagy protein aggregation
European Joint Doctorate in Organocatalysis and Sustainable Polymers (SUSPOL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Joint Doctorates
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany,Spain,Spain,Belgium,France,Netherlands,United States,United Kingdom,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-EJD) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2018-12-31
Duration (months): 48.0
Total project cost (EUR): 2590353.72
EU funding (EUR): 2590353.7199999997
Participants: 10
Project status: CLOSED

SUSPOL-EJD is an European Joint Doctorate in “Organocatalysis and Sustainable Polymers”. SUSPOL-EJD is set up by a consortium formed by four Academic beneficiaries: University of Bordeaux (FR), University of the Basque Country (SP), University of Mons (B) and University of Warwick (UK). Furthermore, six industrial organizations: BASF (D), Purac Corbion (NL), Critical Pharma (UK), Synthomer (UK), IBM (CH and USA) and FORESA (SP) will act as partners collaborating in the research and training activities. SUSPOL-EJD will offer to 10 early stage researchers the possibility of being awarded with double doctoral degrees in two different countries. SUSPOL-EJD will aim at excellence in developing high quality training opportunities for early stage researchers in the area of Sustainable Organocatalysis and Polymers. The final objective is to create scientists who will be the future leaders to make the transition of organocatalysis between the lab and sustainable industrial processes and products. Research and training areas include organic chemistry, catalysis, modelling, polymer engineering, green chemistry, sustainable processes, renewable products, polymer latexes, coatings, biomaterials, pharmaceutical and adhesives. The presence of a high number of industrial partners makes the project highly intersectoral. The research and training programme is very innovative combining frontier research projects and industrial developments

Keywords: organocatalysis,sustainable polymers and procesess
Quantum magnonics in insulators (QUMIN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Condensed matter physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-06-01
End date: 2020-05-31
Duration (months): 60.0
Total project cost (EUR): 2399381.99
EU funding (EUR): 2399381.99
Participants: 1
Project status: CLOSED

In the QUMIN proposal we will build on recent developments in spintronics, circuit quantum electrodynamics and superconducting quantum computing in order to advance the fledgling research field of quantum magnonics. We will employ micro-scale magnonic resonators fabricated from YIG thin films and planar superconducting microwave resonators and superconducting transmon qubits. The combination of these basic elements will enable us to create hybrid magnon/photon and magnon/qubit quantum states and probe and control their joint coherence. An end goal of the project is to controllably entangle a superconducting qubit and a magnet. The concept of circuit quantum electrodynamics, developed in superconducting quantum computing, has enabled strong light-matter coupling at microwave frequencies and has been one of the driving forces behind the advances in quantum computing. Over the same time frame there has been an intense development of microwave spintronics partly motivated by the discovery of spin-transfer torque and spin pumping. Most recently, motivated by its exceptional magnetic properties, there has been a renaissance of research in magnetic insulator YIG. Initial experiments show strong coupling between electromagnetic resonators and magnetic resonators. But this is just the start and a wide variety of increasingly sophisticated experiments are to follow. An important aspect of our proposal is to use the non-uniform modes of micro-scale magnonic resonators, enabling experiments close to or at zero magnetic field to ensure compatibility with superconducting qubits. Furthermore we place an emphasis on the use of microwave spintronic techniques, using the spin-Hall effect in order to control and measure the magnonic resonator. As well as exploring this new quantum magnonics avenue, our proposal will further understanding into the room-temperature magnetic phenomena that make YIG an essential material for microwave electronics.
Places of Togetherness: Investigating the relationship between urban space and social cohesion through the Asia Minor refugee’s courtyards in Nikea (PLAofTOGETHER)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Greece
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-11-29
End date: 2024-05-30
Duration (months): 24.0
Total project cost (EUR): 165085.44
EU funding (EUR): 165085.44
Participants: 1
Project status: SIGNED

Europe has never been homogeneous and is increasingly becoming more culturally, ethnically, and religiously diverse over the last century. In 2018, 2.4 million people migrated to Europe from outside of the continent, while 1.4 million migrated internally. The diversification of European cities can be an opportunity for increased tolerance and bilateral exchange or might lead to conflict and fear. Understanding how our urban neighborhoods and their public spaces facilitate tolerance, rather than fear should be a critical research field within the built environment disciplines, bringing together knowledge from design, geography, and social sciences, all the while informing policy and local government priorities. Current literature supports that inter-group contact can lead to greater levels of tolerance, and spatial conditions can play a significant role in facilitating or inhibiting these interactions. Well-integrated urban spaces such as streets, squares, courtyards etc. within neighborhoods have the potential to enrich public life and in the long run reduce discrimination and fear. At present, there is limited research investigating the types of urban spaces and spatial practices that support positive contact between diverse groups, through a multi-level approach looking at different levels of the system. Moreover, there is limited exploration of the impact and agency of intentional urban commoning practices on facilitating encounters, exchanges, and supporting social cohesion and what role communities and local government can play in nurturing social cohesion through local action. My project, ‘Places of togetherness’ (PLAofTOGETHER) will use transition design and participatory research methods to a. investigate the role urban space play in community cohesion and the social integration of immigrants and b. to develop an innovative participatory tool that can be used to advance marginal urban spaces into places of togetherness by communities and local government.

Keywords: urban space,public space,social integration,urban commons,refugees,participation,communities
GReen Energy Transition Actions (GRETA)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Robust decision making and public engagement
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Germany,Spain,Finland,Finland,Netherlands,Portugal
Call: Social Sciences and Humanities (SSH) aspects of the Clean-Energy Transition (H2020-LC-SC3-2020-NZE-RES-CC, 2020)
Start date: 2021-05-01
End date: 2023-10-31
Duration (months): 30.0
Total project cost (EUR): 3098372.5
EU funding (EUR): 3098371.7800000003
Participants: 8
Project status: SIGNED

The GRETA project aims to improve understanding on the conditions and barriers for energy citizenship emergence. Energy citizenship has come to represent a form of active participation within energy systems that ultimately supports local and global decarbonisation goals. It can manifest in many different ways, such as individual homeowners choosing renewable energy solutions or electric vehicles, participation in energy communities, or advocating for climate change. But not everyone has the possibility to participate. This can be due to a range of factors, including being unaware of issues or their practical solutions; being excluded from debates and decision-making; being prevented from taking action due to lack of resource or lack of power. Through a multinational survey and six participatory case studies, GRETA will develop frameworks and models aimed to reveal what factors affect energy citizenship. These will be utilized within case studies to identify problems, frame solutions and reach consensus on roadmaps for change, formalized through Energy Citizenship Contracts. Findings throughout the project will be utilized to inform and encourage policymakers to advocate energy citizenship.

Keywords: energy citizenship,participation,decarbonisation,models,inclusion,policy