Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Fast quantum ghost microscopy in the mid-infrared (FastGhost)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Sweden,Netherlands
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2019)
Start date: 2020-10-01
End date: 2024-06-30
Duration (months): 45.0
Total project cost (EUR): 2908831.25
EU funding (EUR): 2908831.25
Participants: 5
Project status: SIGNED

Quantum imaging using non-classically correlated photon pairs has been shown to possess a number of fundamental advantages with respect to known imaging modalities based on classical light. These are the possibilities to image with very low photon number while maintaining a high image quality, to have sample interaction and spatial detection on different wavelength channels. Although these advantages signify a large potential for applications, realizations so far only have been on the level of principle demonstrations. The overarching goal of the FastGhost project is to move quantum imaging from a conceptually demonstrated experimental approach to a technology with viable benefits for applications.The strongly linked FastGhost consortium will demonstrate the benefits of quantum imaging in a microscopy lab demonstrator on TRL 4, which will perform measurements with high spatial resolution in the mid-infrared spectral range while employing only spatially resolving detectors for visible light. To this end, photon pair sources optimized for quantum imaging, single-photon detectors for the mid-infrared, and highly resolving single-photon cameras will be developed in the project. The final demonstrator integrates all components and will represent a practically usable imaging device with application-oriented performance parameters. We will show the capabilities of the demonstrator in prototype applications that are targeting imaging in medicine and life sciences. This will enable quantitative assessment of the quantum advantages which will be used to identify marketable application cases.

Keywords: quantum optics,quantum imaging,single photon detection,ghost imaging,mir imaging
OPtimal strategies to retAIN and re-use water and nutrients in small agricultural catchments across different soil-climatic regions in Europe (OPTAIN)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Lithuania,Slovakia,Switzerland,Belgium,Hungary,Lithuania,Poland,Slovenia,Sweden,Hungary,Norway,Norway,Hungary,Poland,Slovenia,Latvia,France,Czechia,Netherlands
Call: Integrated water management in small agricultural catchments (H2020-SFS-2019-2, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 6999856.25
EU funding (EUR): 6999856.25
Participants: 22
Project status: SIGNED

Natural/Small Water Retention Measures (NSWRMs) can help mitigate the conflicts between agricultural water uses (e.g. plant production, animals) and other human and environmental demands for water, including drinking water or maintaining environmental flow. This is crucial, since these conflicts will be probably exacerbated by an increasing number of extreme events such as droughts and heavy rainfall. A more careful management of head watersheds will significantly contribute to a more resilient agriculture and society. Moreover, NSWRMs are contributing simultaneously to the achievement of different Sustainable Development Goals and environmental targets formulated in several water- and agriculture-related European Union policies. Despite a comprehensive set of techniques available to increase water retention on both catchment and farm levels, knowledge is still lacking on the effectiveness of different scale- and region-specific measures across various soil-climatic regions and agricultural systems, especially under changing climate conditions. OPTAIN aims to (i) identify efficient techniques for the retention and reuse of water and nutrients in small agricultural catchments across Continental, Pannonian and Boreal biogeographical regions of Europe, taking into account potential synergies with existing drainage-irrigation systems, and - in close cooperation with local actors - (ii) select NSWRMs at farm and catchment level and optimize their spatial allocation and combination, based on environmental and economic sustainability indicators. By building on existing knowledge and addressing these objectives, OPTAIN will improve the Technological Readiness Level of NSWRMs for the benefit of both humans and ecosystems. All gained knowledge will be translated into a learning environment allowing analysis of trade-offs and synergies between multiple values/goals in the management and design of NSWRMs.

Keywords: natural,small water and nutrient retention,farm and catchment scale,multi actor approach,indicators,integrated assessment,multi objective optimization,policy analysis,learning environment
Proposal for a Horizon 2020 Design Study on the “European Plasma Research Accelerator with eXcellence In Applications“ (EuPRAXIA) (EuPRAXIA)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Italy,France,France,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,United Kingdom,Portugal
Call: Design studies (H2020-INFRADEV-1-2014-1, 2014)
Start date: 2015-11-01
End date: 2019-10-31
Duration (months): 48.0
Total project cost (EUR): 2999900.0
EU funding (EUR): 2999900.0
Participants: 17
Project status: CLOSED

EuPRAXIA will produce a conceptual design report for the worldwide first 5 GeV plasma-based accelerator with industrial beam quality and user areas. EuPRAXIA is the required intermediate step between proof-of-principle experiments and ground-breaking, ultra-compact accelerators for science, industry, medicine or the energy frontier (“plasma linear collider”). The study will design accelerator technology, laser systems and feedbacks for improving the quality of plasma-accelerated beams. Two user areas will be developed for a novel Free Electron Laser and High Energy Physics detector science. An implementation model will be proposed, including a comparative study of possible sites in Europe, a cost estimate and a model for distributed construction and installation at one central site. EuPRAXIA will be a new large research infrastructure with an estimated footprint of about 250 m. If the design study is approved, then it will lay the foundation for a possible decision on construction in 2020. A consortium of 16 laboratories and universities from 5 EU member states has formed for preparing this proposal. 18 associated partners from 8 countries have joined with in-kind commitments (linking 3 additional EU member states). The scientists represent expertise from accelerator operation for photon science and HEP, design and construction of leading accelerators like LHC and Soleil, advanced acceleration test facilities like SPARC and frontier laser projects like CLF, CILEX-APOLLON and ELI. A project with 14 work packages has been defined, 8 of them with funding requested from EU. The proposal has been discussed in the European Steering Group for Accelerator R&D (ESGARD). A statement of strong support has been received. The EuPRAXIA technology is closely linked to EU industry. The director of the THALES Laser Business Unit and the CEO of Amplitude Technologies have sent letters of strong support for the EuPRAXIA proposal.

Keywords: large research infrastructure,user facility,novel accelerator technology,laser technology,plasma accelerator,european industry,free electron laser,photon science,particle physics,design study
Self-OrganizatioN towards reduced cost and eNergy per bit for future Emerging radio Technologies (SONNET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Cyprus,Greece,United Kingdom,Portugal
Call: Research and Innovation Staff Exchange (H2020-MSCA-RISE-2016, 2016)
Start date: 2017-01-01
End date: 2022-06-30
Duration (months): 66.0
Total project cost (EUR): 886500.0
EU funding (EUR): 886500.0
Participants: 4
Project status: CLOSED

A revelation in today´s mobile is networks is SON (Self-Organizing technology) technology, which is seen as a playing pivotal role towards reducing the management costs of networks. In legacy networks, still many network elements and associated parameters are manually configured. The associated operations costs are significant. Specialized expertise must be maintained to tune these network parameters, and the existing manual process is time-consuming and potentially error-prone. In addition, this manual tuning process inherently results in comparatively long delays in updating values in response to the often rapidly changing network topologies and operating conditions, resulting in sub-optimal network performance. SON is capable of collecting information from the network, so as to perform self-configuration, self-optimization, self-healing and etc, so as to reduce the operation cost through less human involvement, and to optimize the service quality through robust and prompt network optimization. In this proposal, we aim to drive further cost savings in the way networks are managed today by amplifying further the coverage zone of SON within the network. We believe that key technologies such as network sharing and Coordinated Multipoint (CoMP) can benefit from SON technology solutions. We will consider a complex context-aware heterogeneous network that is slowly becoming a 5G reality, and investigate the notion of SON CoMP and SO network sharing, as key technologies to reduce cost and energy per bit in legacy and future emerging mobile technologies.

Keywords: self organization,coordinated multipoint transmission,context aware
Paternity leave and the gender gap in pay and earnings (PAGE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-03-01
End date: 2021-05-02
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

This project will estimate the impact of the gender split in parental leave on gender gaps in labour market outcomes and domestic work. I will address this topic, which is of Europe-wide policy relevance, by examining the parental leave policy in Germany. To provide causal estimates, I will make use of variation in the gender split in leave that is due to a cap in the income-related benefit payments at 1,800€ per month. A preliminary step for the analysis, is to confirm empirically that the cap in parental leave benefits does in fact induce variation in the gender split of leave. Following on from this, the main analysis will make use of differences in the gender split in leave that result specifically from the benefit cap in order to answer two questions: Question 1. What is the impact of the gender split in parental leave on the within-household gender gap in labour market outcomes (pay, hours, earnings and employment)? Question 2. What is the impact of the gender split in parental leave on the household division of domestic work and childcare? By answering these questions in a causal sense I address a literature gap in three areas. Firstly, there is currently no evidence on the effect of the gender split of parental leave on the gender gap in pay and only non-causal evidence for the effects on other labour market outcomes such as employment. Secondly, there is only non-causal evidence on the effects of the split of leave on the gender gaps in domestic work and childcare. Finally, there is no evidence on the effect of financial incentives on the split of leave and subsequent gender gaps in labour market outcomes and the division of domestic work and childcare.

Keywords: family economics,policy evaluation,gender pay gap
A scientifically proven Microbiome immunotherapy for the treatment of colorectal cancer (Oncarin)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-05-01
End date: 2018-08-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Following 30 years of research, ZMD has developed ONCARIN; an immunotherapy treatment for the treatment and to boost to immune system of patients with colorectal cancer. The treatment consists of special developed capsules containing a lyophilized mixture of live bacteria (colon flora) with a high oncolytic activity. ONCARIN has the unique ability to both induce cancer cell destruction and activate the immune system. Furthermore the technology allows for an easy synthesis and manufacture enabling the commercialization of a cost-effective product (90% lower than competitor’s prices). No other oncologic drug, currently marketed, is able to address therapy effectiveness, absence of side effects, and healthcare costsavings. In addition, Oncarin can be easily implemented for a wide range of immune conditions including cancer, Crohn’s disease, colities and immune system disorders after long-term treatment with antibiotics. This will improve patient outcomes and greatly reduce healthcare costs. Moreover, ONCARIN costs 90% less than current solutions. ZMD will exclusively license the further development and commercialization of ONCARIN to a pharmaceutical company. Oncarin now has a TRL 6, since successfully completing proof of concept in animal models. The next step to advance TRL is to conduct a phase I trial in order to demonstrate safety and pharmaceutics of Oncarin. Z.M.D Medical Ltd is part of ZMD group ,which includes ZMD Diagnostics Ltd. ZMD Medical develops and commercializes therapeutic remedies to cure cancer of all types using the immune system- first focus- colorectal cancer. Z.M.D Medical has set a goal to produce the drug to rehabilitate distressed colon microflora in order to eliminate cancer from patients’ immune systems. Barak Zigdon, an MBA with significant entrepreneurial experience, leads the team. The team boasts more than 30 years of experience in Cancer research and product development.

Keywords: microbiome,immunotherapy,immune system,cancer,oncology,colon cancer,probiotic
The virulence potential of human pathogens: how Acinetobacter baumannii survives Acanthamoeba castellanii predation (ACtIVAtE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-01-01
End date: 2019-12-31
Duration (months): 24.0
Total project cost (EUR): 172800.0
EU funding (EUR): 172800.0
Participants: 1
Project status: CLOSED

The human pathogen Acinetobacter baumannii represents a deadly threat to human health. Despite its established clinical relevance, the pathogenicity of this nosocomial superbug is poorly understood. The biphasic amoeba Acanthamoeba castellanii is a cellular infection model broadly used to decipher the virulence mechanisms of human pathogens, as bacterial resistance upon amoebal predation (grazing) are often correlated with their pathogenicity potential in human. However, high-throughput screening approaches to investigate the virulence mechanisms of A. baumannii using this amoeba in an infection context are still lacking. This project aims at applying original large-scale screening approaches to identify A. baumannii virulence factors using the amoeba A. castellanii as host-pathogen system. The proposed experimental set up allows monitoring the outcome of the bacteria-amoebae interactions in qualitative and quantitative manners, at both population and single cell levels. Virulence induction of A. baumannii, as well as the use of successful clinical isolates will be tested using several complementary grazing assays. Precise localization of A. baumannii reporter strains will be done on both trophozoite and cyst stages of A. castellanii, complemented with (i) real-time and live-cell fluorescence imaging as well as (ii) electron microscopy techniques. Viability assays for both bacteria and amoebae will be done to understand the symbiotic outcome of this interaction. The global resistance potential of A. baumannii will be assessed by (i) Tn-seq analysis and (ii) high-throughput screen of individual mutant strains, followed by in depth mechanistic studies on validated attenuated strains. This project will shed light on the yet unknown global virulence mechanisms of A. baumannii by generating original screening methods using A. castellanii as an infection cellular model.

Keywords: host pathogen interactions,high throughput screening approach,human pathogen,virulence factors,pathogenicity,gram negative bacterium,amoeba,macrophages,epithelial cells
Boosting future careers, education and research activities in the European bio-based industry (UrBIOfuture)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Public-private partnerships
Destination: Bio-based Industries
Action type: Coordination and support actions
Partnership: BBI (Art-187)
Countries involved: Spain,Italy,Spain,Spain,Belgium,Finland,Poland,Netherlands,Denmark
Call: Identify opportunities to promote careers, education and research activities in the European bio-based industry (H2020-BBI-JTI-2018, 2018)
Start date: 2019-05-01
End date: 2020-04-30
Duration (months): 12.0
Total project cost (EUR): 996385.0
EU funding (EUR): 946567.65
Participants: 9
Project status: CLOSED

UrBIOfuture main goal is to bring Europe to the forefront of the bio-based sector by boosting careers, new educational programmes and research activities. This approach is intended to be developed in this project as a 3-step methodology: (1) An identification step, involving career mapping of programmes involving bio-based activities and pointing of skills mismatch between them and the bioindustry needs as main KPIs, alongside with a previous methodology and work terminology developed and aligned between the educational sector and the industry needs. (2) An interaction step, in which the constant contact and contributions of the education sector, academia and industry will be sought throughout the project. The KPIs involved will be (a) building a comprehensive stakeholder network and a working group involving representatives from each sector of the bio-based value chain. The project has already received the support of 72 organizations from bio-based industries (38 LOIs), educational institutions and networks (15 LOIs), and from innovation and research centres (19 LOIs); and (b) the organisation of two workshops in which this group will participate. The first will seek dialogue between the different profiles to validate the common terminology and methodology, and the second will consist of a co-creation exercise to set the basis for promoting careers in the bio-based sector. (3) The implementation of UrBIOfuture, through an appropriate Communication and Dissemination plan; the organization of promotional events, train-the-trainer and train-the-student workshops; and the development of an afterlife plan will ensure the broader impact of the results materialised in the project among the European bio-based sector. The results of UrBIOfuture will help building a bio-based industrial sector with the adequately skilled people, that are able to operate innovative value chains while establishing and sustaining a solid bio-based industry in Europe.

Keywords: bio based industry,bioeconomy,bio based competences,map of career paths,educational programmes,professional skill needs and gaps,co creation workshop,european bio based stakeholders
Full human-based multi-scale constructs with jammed regenerative pockets for bone engineering (REBORN)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Products and processes engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Portugal
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2021-11-01
End date: 2026-10-31
Duration (months): 60.0
Total project cost (EUR): 2499683.0
EU funding (EUR): 2499683.0
Participants: 1
Project status: SIGNED

Engineered bone tissue has been viewed as a potential alternative to the traditional use of bone grafts, due to their limitless supply and no disease transmission. However, bone tissue engineering practices have not proceeded to clinical practice as it was not yet possible to fully recreate the right conditions to produce relevant large vascularized grafts and enabling their in vivo integration and remodelling. REBORN proposes rather unique toolboxes combining bionstructive biomaterials only based on human proteins obtained from the amniotic membrane (AM) and cells from the umbilical/blood cord for the ground-breaking advances of engineering totally time-self-regulated complex 3D devices, able to adjust the cascade of processes leading to faster high-quality and vascularized new bone tissue formation with minimum pre-processing of cells. Proteins from AM will be chemically modified with bioorthogonal clickable moieties enabling their selective association during the fabrication of liquified pockets or hydrogels. Perm-selective AM-protein membranes will be formed at the interface of aqueous-based emulsions to produce liquified pockets confining all necessary ingredients for internal in vitro tissue development to recreate the bone niche including: (i) the correct cells’ ratio, (ii) hydrogel MicroBlocks that will provide geometrical, mechanical and topographic cues to control cellular behaviour and (iii) bioactive soluble factors. Jammed liquified pockets will be assembled into a final desired implantable device, bound by the developed hydrogels, with clinically relevant size, shape and structural integrity, using non-conventional 3D bioprinting processing methodologies or by physical fixation in bioinspired, periosteum-like, regenerative membranes. Advanced techniques will be employed to characterise the new tissue developed in the hybrid devices, from the ultrastructure of the mineral/organic component, including under distinctive dynamic culturing conditions.

Keywords: bone engineering,bioprinting,biomaterials design,biomimetics,macromolecular design,human proteins,structural hydrogels,biomaterials processing,microfabrication