Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The Human-Tech Nexus - Building a Safe Haven to cope with Climate Extremes (The HuT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Disaster-Resilient Society for Europe
Action type: Innovation actions
Countries involved: Italy,Finland,Iceland,Spain,Switzerland,United Kingdom,Germany,Austria,Slovakia,Lithuania,Hungary,Norway
Call: Integrated Disaster Risk Reduction for extreme climate events: from early warning systems to long term adaptation and resilience building (HORIZON-CL3-2021-DRS-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 4928531.25
EU funding (EUR): 4793643.5
Participants: 27
Project status: SIGNED

The HuT will employ innovative disaster risk reduction solutions, accounting for the potential variations induced by climate change. This will involve integrating and leveraging best practices and successful multi-disciplinary experiences that have been recently developed within various territorial contexts by leading European research groups, institutions, and stakeholders, to deal with extreme climate events. The project’s main ambition beyond the state of the art is to promote the “best set” of trans-disciplinary risk management tools and approaches that could be adopted and used extensively across Europe, in as many situations as possible. The activities of the project will be developed considering the following main critical dimensions: trans-disciplinarity, systemic risk, co-production, cross-fertilization, transferability, and long-term legacy. A set of ten demonstrators will constitute a multi-hazard arena wherein possible disastrous events associated with climate extremes will be dealt with jointly by representatives of the scientific and technical communities, practitioners, policy-makers and local communities. The events associated to climate extremes that will be considered in this project are: forest fires, including wildland urban interface fires; meteorological/hydrological/agricultural droughts, including associated water shortage; heatwaves; weather-induced landslides, including debris flows; fluvial and pluvial floods; storms, including heavy rain, hail, thunderstorms, and storm surges. The HuT will mainly focus on the prevention and preparedness phases of the disaster risk management cycle, explicitly considering climate change scenarios and integrating the proposed set of solutions, for the various events considered, over short- (from days to several months) and long-term (from years to decades) time horizons.

Keywords: risk awareness,community engagement,multi hazard,systemic risk,transferability,cross fertilization,environmental and economic sustainability
Pulmonary drug delivery using low shear nebulization sprays (SprayDelivery)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-08-31
Duration (months): 28.0
Total project cost (EUR): 237375.04
EU funding (EUR): 237375.04
Participants: 2
Project status: SIGNED

Respiratory diseases are one of the leading causes of death worldwide. The recent global pandemic of severe acute respiratory syndrome (SARS-CoV-2) has made us realize that effective and widely acceptable therapies against such diseases are still lacking and urgently needed. Administering drugs through aerosolization directly to the lungs, i.e. pulmonary delivery, enables targeted therapeutic effects while minimizing side effects by reducing systemic drug exposure. However, generically aerosol delivery is not very efficient, with only 5-15% of the initial medication deposited in the lungs. This is primarily linked with a wide aerosol drop size distribution, leading to inefficient aerosol deposition in the upper rather than lower respiratory tract. In addition, degradation of the medication during nebulization is also a challenge. This project aims to bridge the gap between aerosol generation and the deposition and transport of medication into the respiratory tract. We first propose an innovative soft nebulization method that reduces aerosol droplet coalescence by charging aerosols through friction. We will then use this optimized nebulization method to investigate how medication aerosols impact on the mucus in the respiratory tract, and devise strategies to enhance targeted aerosol deposition. In addition, we will investigate the transport of drug formulations within the airways in relation to their different rheological properties related to typical various respiratory diseases. This project will establish transformable and applicable technologies for advancing aerosol drug delivery to the respiratory tract.

Keywords: aerosols,spray,fluid dynamics,drug delivery,lipid nanoparticles,mucus,respiratory diseases
The Writers and the Totalitarians: The Scandinavian-speaking Writers’ Associations in the European Schism, 1933-1953 (WatTs)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark,Norway
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-05-01
End date: 2028-04-30
Duration (months): 24.0
Total project cost (EUR): 263393.28
EU funding (EUR): 263393.28
Participants: 2
Project status: SIGNED

The Writers and the Totalitarians (WatTs) analyzes dynamics of great relevance to our current era by exploring how totalitarian cultural diplomacy and soft power was exercised, received, and negotiated by writers and intellectuals in the Scandinavian democracies during the political polarization that marked “the European schism” of the interwar, Second World War, and early Cold War years. The political and ideological dividing lines that came to define European political life with ever-greater starkness from the early 1930s onwards could not but make a mark on Scandinavian intellectual life. WatTs examines how the national writers’ associations in Denmark, Norway, and Sweden as well as the Swedish-speaking writers’ association in Finland reacted to and interacted with the German National Socialist and Soviet Communist regimes from 1933 and into the immediate post-war period. Despite their importance as fora for shaping, legitimizing, and discussing the attitudes and actions of Scandinavian-speaking writers, historical research has paid little attention to the writers’ associations, and even less to their roles and reactions vis-á-vis the epochal political, ideological, and cultural developments taking place in the Nordic countries’ Southern and Eastern neighbor states in the interwar years and beyond. By utilizing several understudied archival collections located across the Nordic region, which have never been studied in conjunction, WatTs heeds the transnational turn in historical studies and explores how the leaders and memberships of the Scandinavian-speaking national writers’ associations reacted to, interacted with, and positioned themselves vis-á-vis the Third Reich and the Soviet Union and their respective cultural diplomatic efforts, and how, in doing so, they both acted according to and shaped the norms of an important but overlooked transnational Nordic literary-intellectual field.

Keywords: literature and politics,national socialist germany,the soviet union,history of the nordic countries,scandinavia,cultural diplomacy,cultural sociology,soft power
Performance Estimation, Assessment, Reporting and simuLation (PEARL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Coordination and support actions
Partnership: SESAR (JU-JTI)
Countries involved: Spain,Portugal,Lithuania,Norway,United Kingdom,Belgium,France,Italy,Sweden
Call: Performance Management & Network impact Assessment (HORIZON-SESAR-2022-DES-IR-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 9862263.76
EU funding (EUR): 1989359.27
Participants: 22
Project status: SIGNED

PEARL project aims at carrying out the SESAR performance management process, under the leadership of SESAR 3 JU. This implies to reconcile and map the performance assessments and results delivered by the R&I projects with the SESAR performance ambitions in the ATM Master Plan. To achieve this goal, PEARL Project will conduct the following activities: -A priori estimation of performance contributions from SESAR Solutions -Consolidation of performance assessments coming from SESAR Solutions to deliver PAGAR report -Provision support and guidance to Solutions through Communities of Practice (in performance domains as Operational Performance, Safety, (cyber) Security, Human Performance, Environment, CBA, Digitalisation and U-Space), as part of a Quality Assurance process -Conduct multi-SESAR Solution network impact simulations, looking for indications of cross-effects of joint deployment Complementarily, on specific request from SESAR 3 JU, PEARL project will maintain SESAR Performance Framework and related material, as well as providing support to Maturity Gates. It will also be flexible for the provision of additional ad-hoc activities, to be agreed with SESAR 3 JU.

Keywords: atm performance,network impact simulation,sesar performance framework,digitalisation,u space
Materials-GRoWL: Gauging the Rest-of-World’s Lifecycles of construction materials (Materials-GRoWL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

This project, Materials-GRoWL, will assess the current and future construction material uses that compose human settlements of the Global South, which is sometimes indiscreetly aggregated as the Rest of the World (RoW) in global studies. This is crucial, because construction materials have global environmental impacts: half of yearly consumption of all raw materials, significant shares of carbon emissions, and major contributors to land use change. Most of their future demands and thus environmental and societal impacts will occur in the global south. This is also challenging, because understanding the lifecycles of construction materials – how many and which materials, where are they used, to what ends, and with which impacts – has been daunting due to limited data and research frameworks. The Global South has been neglected so far, and the little understanding we have is incomplete, uncertain, and incoherent. Thus the environmental and socioeconomic risks related to construction material use in the RoW countries now and in upcoming decades are only generically studied or remain unknown. Materials-GRoWL will: 1. Develop novel methodologies to produce high-resolution construction material data in the Global South and link these to the societal services and human needs they provide; 2. Compare future material use developments to 2070 under a suite of different socioeconomic and wellbeing pathways; 3. Identify environmental and socioeconomic risks imposed on and by construction material accumulation; and 4. Form an exchange framework for cross-transfer of material use knowledge. Materials-GRoWL will overcome the severe data and methodological challenges that held back the study of construction material use in the Global South. It will provide data and methods crucial for addressing the SDGs and material prerequisites of decent living standards. The results will link the development of the built environment with its impacts to inform further research, policy and action

Keywords: industrial ecology,material flow analysis,social economic metabolism,material stocks,sustainable resource use,build environment
Flight Centric ATC Project (FCA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Germany,Czechia,Spain,Denmark,Belgium,Ukraine
Call: Industrial Research & Validation for Master Plan Phase C Connected and Automated ATM (HORIZON-SESAR-2022-DES-IR-01, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 4007036.25
EU funding (EUR): 2555672.89
Participants: 9
Project status: SIGNED

The Flight Centric ATC project (FCA) addresses Industrial Research & Validation for Master Plan Phase C Connected and Automated ATM (HORIZON-SESAR-2022-DES-IR-01-WA6-1). The main objective of FCA is to finally develop (V3 Maturity level) the Flight Centric ATC concept for an ECAC-wide implementation in medium density traffic areas considering the existing national boundaries. Furthermore, the project includes the development of ECAC-wide deployment scenarios, which are consistent with the limitations of the VHF spectrum for voice communications. ECAC-wide benefits of the concept in each of the deployment scenarios will be analyzed as well, based on the exiting SESAR2020, PJ.10-W2-73 FCA Cost-Benefit Analysis. Two different exercises and workshops will be conducted during the project to address the remaining gaps and to take the final step from a V3 on-going solution to a V3 completed solution. Therefore, an analysis will be conducted to validate the Key Performance Indicators: Cost Efficiency (CEF2), Capacity (CAP), Predictability (PRD) and Fuel Efficiency (FEFF), as well as Human Performance and Safety. In addition, final validations will take place to validate e.g. the change from a sectorised airspace to Flight Centric ATC and vice versa, to assess the possibility of a fallback scenario, to evaluate an appropriate allocation strategy and an acceptable approach for the opening and closing of CWPs. The final results will be dissiminated across the relevant stakeholders and the S3JU via scientific papers, open days and a project website specificly designated to the Industrial Research Flight Centric ATC project.

Keywords: flight centric atc,fca,sectorless
Towards high-affinity ligands for orphan receptors GPR3, GPR6 & GPR12 (ToBeLi-for-GPR3-6-12)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-06-01
End date: 2024-07-31
Duration (months): 26.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: CLOSED

The family of G protein-coupled receptors (GPCRs) comprises more than 800 human cell surface receptors that perceive and transmit extracellular stimuli into the cell interior. Due to their involvement in numerous biochemical processes, GPCRs represent prime targets for the treatment of various diseases and are modulated by more than 30% of approved drugs today. However, a large proportion of the druggable GPCRome remains pharmacologically untapped, including the so-called ‘orphan’ GPCRs (oGPCRs) - receptors for which the endogenous ligands remain unknown. GPR3, 6 and 12 constitute a cluster of orphan GPCRs that is involved in numerous (patho-)physiological processes including neurodegenerative disorders such as Parkinson’s and Alzheimer’s dementia. GPR3 and GPR12 further mediate meiotic arrest in oocytes and suppress the development of metabolic diseases. Other physiological processes and diseases associated with GPR3/6/12 are neuropathic pain perception, addiction and different forms of cancer. Although these receptors represent promising pharmacological targets and researchers have been trying to discover molecules targeting these receptors for more than two decades, only a limited set of five ligands is currently available. Modern GPR3/6/12-targeted drug discovery is still hampered by the lack of verified endogenous ligands, our poor understanding of their structural organization and signalling cascades promoted by these receptors, and a limited panel of assays revealing GPR3/6/12 activity in living cells. Here, I propose to implement an interdisciplinary research approach combining computational methodologies with advanced biosensor technology in order to discover advanced ligands for these attractive drug targets. These novel compounds will aid in developing advanced therapeutics tackling severe human diseases and our reseach will highlight the power of interdisciplinary drug discovery approaches, promoting their implementation in the GPCR field and beyond.

Keywords: orphan gpcrs,ligand discovery,virtual screening,biosensors
Broad-spectrum Antiviral siRNAs: Influenza Strains Targeted by Anticipation (BARISTA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-04-01
End date: 2026-09-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Fighting emerging viruses has been a major challenge in the development of novel therapeutics. With the current global changes and massive modification of the biosphere, the issue will surely increase in the future. To overcome this challenge, we will demonstrate on influenza that we are capable to produce active antiviral against a strain that is not yet existing. The BARISTA project will allow to develop a novel therapeutic approach allowing to preserve therapeutic activities over a wide range of influenza strains and we will demonstrate its efficacy on the influenza strain of the next outreach. This achievement will be obtained by guiding the design of chemically optimized siRNA by detailed NMR structural analysis. Those molecules will be tested both in vitro and ex vivo and their broad-spectrum activity will be demonstrated on past, present and future influenza strains. This project will therefore open the way to therapies that can be designed and optimized, even before the appearance of a novel strain, providing an invaluable help in fighting emerging viruses.
Consortium for the AdVent of aero-Engine Demonstration and aircraft Integration Strategy with Hydrogen (CAVENDISH)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Aviation
Action type: Innovation actions
Partnership: CLEAN-AVIATION (JU-JTI)
Countries involved: Germany,France,Spain,United Kingdom,Brazil,Netherlands,Portugal
Call: Direct Combustion of Hydrogen in Aero-engines (HORIZON-JU-Clean-Aviation-2022-01, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 25676275.34
EU funding (EUR): 19236881.35
Participants: 22
Project status: SIGNED

In line with the European Green Deal target of reaching carbon neutrality in the aviation industry by 2050, breakthrough technologies related to direct (100% hydrogen) combustion systems will be researched, prototyped and integrated onto a modern donor aeroengine for ground testing (starting in late 2024) in Project CAVENDISH. This aeroengine test on liquid hydrogen will be a first of a kind in Europe and the cornerstone to further in-flight demonstration, eventually leading to product development aimed at meeting Europe’s and the industry’s ambition for the entry in service (EIS) of commercial, mass-transport, hydrogen-fuelled aircraft in 2035. CAVENDISH’s second objective will be to work on system and powerplant aircraft integration with several established airframers and a supplemental type certificate organisation to define certification pathways and formulate a route to permit to fly. This activity will directly benefit the flight test of the donor engine scheduled for the next phase of the Clean Aviation programme. CAVENDISH will also explore alternative enabling technologies in the form of a dual fuel combustor system (capable of operating on 100% hydrogen and 100% SAF) and in the form of a cryo-compressed tank system. Both these technologies will offer flexibility and could ease the introduction of hydrogen in aviation. CAVENDISH brings together expertise-leading European organizations in aeronautics, power and propulsion, combustion, fuel and controls systems and aircraft. It builds on multiple national technology programmes heralding from the UK, Germany, France and the Netherlands, and is in effect the marriage and acceleration of these technology pathways into an early demonstration and a first minimum viable product (MVP) of a liquid hydrogen combusting aeroengine. The project is also connected to activities in other Clean Aviation calls, on SMR and Certification activities specifically, notably project proposals HEAVEN and CONCERTO.

Keywords: hydrogen,green deal,sustainable aviation,aeroengines,fuels,electrical power,combustor,donor engine,safety of flight,thermal management,propulsion,gas turbine,exhaust
Retina-Seal: Gene therapy mediated regulation of the blood retina barrier (Retina-Seal)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Ireland
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2024-POC, 2024)
Start date: 2025-05-01
End date: 2026-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Age-related macular degeneration (AMD) is the leading cause of irreversible central blindness in the world. The number of people with AMD is predicted to be 288 million by 2040, with an estimated 1 in 10 people over the age of 55 already showing early signs of the condition. At the inner blood retina barrier (iBRB), claudin-5 is the most enriched component of the tight junctions of endothelial cells, regulating the paracellular diffusion of molecules into and out of the retina. As part of the on-going ERC Consolidator grant Retina-Rhythm, we now have a very large body of data suggesting “leaky” or “CLDN-5 depleted” retinal vasculature drives the accumulation of waste material known as drusen, the hallmark diagnostic feature of AMD. Therefore, methods aimed at enhancing CLDN-5 expression can potentially stabilize vascular integrity and prevent the onset of AMD (both dry and wet AMD). Here, we will develop novel adeno-associated viruses (AAV) that will directly regulate the expression of 2 novel target genes and effectively "seal" the blood retina barrier and stabilise disease progression.