Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Widening Synergies for Novel Enzymes Development (WIDEnzymes)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Chemistry
Countries involved: Latvia,Slovakia,Italy,Spain,Greece
Call: Pathways to Synergies (HORIZON-WIDERA-2023-ACCESS-04, 2023)
Start date: 2024-04-01
End date: 2027-03-31
Duration (months): 36.0
Total project cost (EUR): 1199475.0
EU funding (EUR): 1199475.0
Participants: 6
Project status: SIGNED

The "Widening Synergies for Novel Enzymes Development" (WIDEnzymes) project aims to foster the creation of a unique cross-border collaborative ecosystem devoted to advancing enzyme technology in the EU. This endeavor follows the well-established Profiling Regional Innovation Ecosystems methodology and centers its efforts on two key domains: joint internationalization and inclusive talent development. Through the implementation of strong synergies within the consortium, beneficiaries will be able to both enhance their potential and increase the impact of their research projects significantly. Sharing competencies and state-of-the-art equipment will allow the beneficiaries to increase their critical mass and scientific excellence, and therefore to compete in Horizon Europe calls with European countries whose R&I potential is traditionally more established. The inclusion of two non-widening partners, one academic and one SME, with strong expertise in innovations' exploitation, large public-private partnerships, and different EU funding applications is a key accelerator factor to elevate the consortium's preparedness and competitiveness. It is envisioned that the vigorous training and student exchange program implemented by WIDEnzymes will attract students and young researchers alike, thus allowing the creation of a highly educated and competitive workforce that can tackle ambitious research projects and secure funding at the European level. The WIDEnzymes project seeks to bridge borders and boundaries in the pursuit of cutting-edge enzyme technology. By fostering collaboration, leveraging funding opportunities, nurturing talent, adopting a multisector approach, and enhancing visibility, we aim to propel enzyme technology to new heights. Through these endeavors, we aspire to make a lasting impact on science, industry, and the society at large.

Keywords: enzymology,biotechnology,enzyme engineering,molecular simulations,ecosystem,directed evolution,upscaling,knowledge transfer,manufacturing,trans sectoral cooperation,cohesion policy
Multidisciplinary Assessment of Crustacean Sentience (MACS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain,Norway,Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2028-02-29
Duration (months): 30.0
Total project cost (EUR): 206641.2
EU funding (EUR): 206641.2
Participants: 3
Project status: SIGNED

Crustacean sentience (the capacity of this group to experience emotions) has sparked a heated debate across multiple disciplines, particularly as it could impact several major sectors such as fisheries and aquaculture. The outdated argument that animals do not experience negative emotions (such as pain) because they lack conscience, has been proven wrong for vertebrates and some invertebrates (e.g. octopus), but remains controversial for crustaceans. There is evidence of criteria consistent with the idea of pain, as crustaceans have and activate nociceptive pathways, but there is no evidence of the neural pathways integrating the responses nor the demonstration of the awareness thereafter. This is partly due to the ‘dispersed’ central nervous system (CNS) these animals present, with multiple ganglia, but no ‘brain’ as a focal point. To overcome this, MACS aims to apply new technology to measure 9 simultaneous nerve signals (8 ganglia and the heart) to fully understand the nociceptive pathways and how are they integrated in crustaceans’ CNS. This approach will tackle the principle of triangulation by (1) The development of an electroencephalogram (EEG) to record the nervous system of commercially important crustacean species; (2) the characterization of pain and stress through physiological and molecular animal-based indicators; and (3) the evaluation of behaviour and its neurological integration pathway. As such, this multidisciplinary study will only be possible through a combination of my crustacean stress physiology background, my supervisor’s knowledge of the central nervous system anatomy, and my second supervisor's expertise in aquatic species' EEG. The outcome of this fellowship will range from CNS studies to validate current industrial practices (during a non-academic placement), to socio-economic impacts involving the society's concern for animal welfare. The knowledge and skills gained from this project will allow me to become an independent researcher.

Keywords: crustacean sentience,animal welfare,nociception,animal based indicators,seafood industry
Healthy Soil to Permanent Crops Living Labs (LivingSoiLL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Research and Innovation actions
Countries involved: Portugal,Italy,Spain,France,Poland,Belgium
Call: Co-creating solutions for soil health in Living Labs (HORIZON-MISS-2023-SOIL-01, 2023)
Start date: 2024-06-01
End date: 2028-11-30
Duration (months): 54.0
Total project cost (EUR): 11999990.0
EU funding (EUR): 11999990.0
Participants: 51
Project status: SIGNED

Healthy soil is at the heart of the European Green Deal and one of the main targets of the Mission Board. The EU is currently struggling with soil degradation which is undoubtedly linked to agriculture intensification. Thus, a new soil management paradigm on soil monitoring, restoration and protection must be an endeavour of farmers, scientists, businesses, politicians and citizens. LivingSoiLL intends to respond to these challenges by establishing 5 Living Labs (LLs) in PT, FR, ES, IT and PL focused on permanent crops (vineyards, olive groves, chestnuts, hazelnuts and apple orchards), comprising at least 50 demonstration sites and 10 lighthouses, and with active participation of more than 2000 local actors. These LLs will focus on improving healthy soils and ecosystem services through co-creating, co-implementing and co-testing (digital) solutions to reduce erosion, improve soil structure, reduce the impacts of the intensive use of fertilizers and pesticides, increase water storage, enhance soil biodiversity, and the overall resilience of soil. By promoting locally adjusted innovative solutions, spreading sustainable soil management practices and enhancing soil literacy, LivingSoilLL will contribute to the overall improvement of soil health and environmental resilience. This approach, applied in real-life settings, will mobilize farmers, farm advisors and local communities, facilitating the assemblage of formal, scientific knowledge with experience-based farmer´s know-how, fostering a forum for the exchange of experiences and best practices. LivingSoilLL is also designed to produce policy recommendations on best soil management practices on permanent crops to reduce erosion while promoting other soil health indicators. With its approach, LivingSoiLL projects intends to contribute to creating the necessary conditions to EU be able to sustain healthy soils for future generations

Keywords: permanent crops monitoring schemes soil health indicators ecosystem services sustainable management practices innovative co creation
ULTRA-LIGHT, SELF-CORRECTING, “LIVE” MIRRORS: Lowering the areal density of mirrors and maximizing performance with non-abrasive, additive, 3D-printed novel technology. (Live-Mirror)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,Spain,Germany,Italy
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-02-01
End date: 2027-01-31
Duration (months): 48.0
Total project cost (EUR): 3334517.5
EU funding (EUR): 3334517.5
Participants: 7
Project status: SIGNED

We propose to develop ultralight, self-correcting mirrors for use in the next generation of large optical telescopes and solar energy concentrators. Presently, the best mirrors have a density of about one-half a metric-ton per square-meter or more in order to provide the stiffness which is necessary to keep the optical shape under the variable conditions given by the changing gravity vector as the telescopes track a position on the sky, as well as to withstand variable wind conditions. We intend to replace such a massive mirror with a “sandwich” of very light, optically perfect, “fire-glass” (window pane) coated sheets stiffened with layers of Electro-active polymers that can be deposited through additive manufacturing 3D printers. The sheets of glass will be heated to ~800o C in a pressurized, tailored made kiln and allowed to relax (their backside) onto a suitable mould, cast to a predetermined off-axis aspheric (parabolic) shape, while keeping the temperature below the de-vitrification temperature of the glass thus preserving the excellent optical surface quality of fire-glass window pane. Using the addressable energy of the Electro-active polymers will provide not only dynamically self-controlled stiffness but also variable push-pull action real-time multi-sensing controlled and calibrated in order to keep the optical surface to a “live-perfect” shape under general operating conditions. These “Live-Mirrors” shall provide optical surfaces of as high a quality as those of the current best telescopes but with larger dynamic range and a reduction in weight and cost of more than one order of magnitude. Such mirrors will allow the development of 50-100 meter-class telescopes as well as of the next generation of space telescopes. On the ground, they will also offer very low cost options for the next generation of solar energy concentrators and for antennas used for optical communications.

Keywords: additive manufacturing,electro active polymers force actuator,hybrid meta material,large lightweight optical mirror,multi sensing control,glass slumping,aspheric shape determination
Learning to Donate (LEARN-DO)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Netherlands
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-03-01
End date: 2025-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Background. Without blood donors, there are no blood products to transfuse and no plasma for pharmaceutical drug production. Four million patients are annually treated with blood derived products in Europe alone, given by voluntary donors. Yet, as little as 2-3% of the population is registered as blood donor and donor numbers are decreasing during the last decades. At the same time, the demand for specific blood products is increasing. Hence, it is crucial that a country’s donor pool is sufficient to ensure access to every needed blood type and plasma product. Targeted recruitment and retention of donors is vital to meet these demands. Aim. LEARN-DO intends to develop and market a fun and interactive knowledge intervention to stimulate key motivators and overcome key barriers for individuals to become a blood donor. Approach. We target two main stakeholder groups with this intervention. Individuals (children and adults) who can be potential future donors and blood collection agencies that need to recruit future donors to meet the demands for blood products. We propose three installation elements that manipulate key barriers and motivators of blood donation. A Donor Picture Pillar that provides information about blood donation and shows patient and donor stories. A "Donation Experience" to decrease fears and psychological distance towards blood donation and a Conversation Couch to stimulate talking about donation among participants. Organisation and Impact. The project is organised in four work Packages (WP). The overarching project management (WP1, led by the PI at the host institute) will ensure that the impact proposition will include all scientific (WP2), technical/education (WP3) and business (WP4) aspects. LEARN-DO can thoroughly change the recruitment of future donors and improve the recruitment strategy of blood collection agencies by making them more evidence-based, fun and interactive and targeted to specific groups, including families and members from ethnic minorities.
DIGITAL and DEEPTECH SCALE-UP ACTION FOR LEADERSHIP OF EUROPE IN TRANSPORT, LOGISTICS, TRADE AND SMART CITIES (D2XCEL)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: other EIC
Destination: Other destinations
Action type: Coordination and support actions
Countries involved: Bulgaria,Belgium,Finland,Greece,Germany,France,Poland,Netherlands
Call: Enhancing synergies between the EIC and Startup Europe (HORIZON-EIC-2022-STARTUPEU-01, 2022)
Start date: 2023-11-01
End date: 2026-04-30
Duration (months): 30.0
Total project cost (EUR): 1993088.75
EU funding (EUR): 1993088.75
Participants: 13
Project status: SIGNED

D2XCEL establishes and deploys a sustainable scaling platform, acting as catalyst to strengthen the effectiveness and efficiency of the existing European startup ecosystem to support deep tech and digital ventures successfully provide market-ready applications, flourish, grow strongly and increase the market footprint of European deep tech Startups and scaleups that contribute substantially to the sustainability and European sovereignty of key sectors such as Transport, logistics & trade and adjacent areas of Smart Cities (mobility, utilities, sustainable construction). D2XCEL supports the existing startup ecosystem actors with state-of-the-art methodologies, best practices, tools and especially pan-European networks. These will be developed and deployed in a program with 100 selected high-potential ventures, assuring both direct impact on the success of those ventures as well as hands-on experience of the ecosystem actors. D2XCEL first builds a network of 300 active key stakeholders and identifies market opportunities holding significant demand and growth potential and builds the needed knowledge to scale related companies. It then launches an open call to attract in 2 rounds 100 best companies (10 in each area) and provides them efficient mentoring to help them address their individual challenges and build strategic plans. It then connects them with active investors, corporate partners, lead customers (private and public) and talent. Raising visibility on the supported companies is also delivered to the portfolio companies as service. D2XCEL brings together a wide consortium of 13 partners from 8 countries, widening countries well represented. It will result in min. 25 companies raising avg €2Mln investment and 25 companies closing partnership with avg value €2 Mln (Total 100 Mln) while hands-on experience by the participating ecosystems builds their capabilities to scale deep tech companies and expand their networks.

Keywords: acceleration deep tech ecosystem building
Stable solutions and nonstandard diffusions: PDE questions arising in Mathematical Physics (SSNSD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-10-01
End date: 2029-09-30
Duration (months): 60.0
Total project cost (EUR): 1682500.0
EU funding (EUR): 1682500.0
Participants: 1
Project status: SIGNED

The concept of diffusion is ubiquitous in the physical sciences. From the mathematical point of view, its study started in the early 19th century with the development of PDE theory, and has many connections to Physics, Probability, Geometry, and Functional Analysis. This project aims to answer several outstanding questions related to the mathematics of diffusion. The proposal is divided into two blocks. The first one corresponds to the study of stable solutions to reaction-diffusion PDE, and more precisely the classification of global stable solutions in the physical space (i.e., in 3D) for a general class of problems including the Allen-Cahn, the Alt-Phillips, or the thin Alt-Caffarelli equations. We will also investigate the same question for complex-valued solutions in 2D, which arises in the construction of travelling waves for the Gross-Pitaevskii equation. The second block corresponds to nonstandard diffusions. In particular, we will study the Boltzmann equation (a fundamental model in statistical mechanics), nonlocal diffusions (deeply related to Lévy processes and "anomalous diffusions''), as well as the porous medium equation (a classical nonlinear PDE that arises in various physical models in which diffusion is "slow''). The highly ambitious goals of the project are motivated by some recent results obtained by the PI in these areas.
Researchers and citizen creating together a better future (NIGHTMADRID)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: European Researchers' Night
Action type: Coordination and support actions
Countries involved: Spain
Call: European Researchers' Night and Researchers at Schools 2024-2025 (HORIZON-MSCA-2023-CITIZENS-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 337424.15
EU funding (EUR): 337424.15
Participants: 14
Project status: SIGNED

The project will bring together researchers to the general public and will increase awareness of research and innovation activities, with a view to supporting the public recognition of researchers. The European Researchers' Night in Madrid will bring together researchers to the general public and will increase awareness of research and innovation activities, with a view to supporting the public recognition of researchers, creating an understanding of the impact of researchers' work on citizen's daily life, and encouraging young people to embark on scientific careers. The project will implement it by means of a set of festive activities to be carried out in the Region of Madrid on the morning and evening of the last Friday of September. The activities will be addressed to public at large, science-addicts and science-reluctant, children, families, teachers, elderly, people regardless their scientific background with a special focus on young people: secondary and primary school students with the main purpose of encouraging STEM subjects and science careers, university students and also vocational education and training students. The event will involve researchers, benefited by EU funds, especially the Marie Sklodowska-Curie Actions (MSCA). Their presence in the activities at the European corners will point out the transnational and diversity aspects of research, showing the attractiveness of their jobs that can be done everywhere in Europe. Regional and Academic authorities, stakeholders and managers from universities, research centres, museums, hospitals, NGOs, foundations and industry (Spin offs, SME or Large Companies) in the Region of Madrid will be at the core of the project.

Keywords: night,european dimension,european missions,scientific vocation
Spatiotemporal regulation of metastatic breast cancer cell fate (METspread)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-05-01
End date: 2031-04-30
Duration (months): 60.0
Total project cost (EUR): 2028936.0
EU funding (EUR): 2028936.0
Participants: 1
Project status: SIGNED

Breast cancer is the most common malignancy in women with globally over 600’000 deaths per year. While cancer diagnosis before metastasis is often associated with a favourable prognosis, due to surgical and new therapeutic approaches, once metastasis is initiated, the survival rates decline significantly. However, the understanding of this last and most detrimental phase of cancer remains at a low resolution, reflected by the lack of metastasis-targeted therapeutic options. In fact, most of the studies have focused on the understanding of primary tumour states and their relationship to metastasis. Recently, it has emerged, however, that secondary seeding from metastatic deposits to new sites plays a role in cancer spread. We made an unexpected discovery that the cancer cells metastasised to different sites display dramatically distinct molecular and functional properties, thereby having diverse impacts on cancer progression. This highlights a previously underappreciated role of secondary seeding and emphasises the need to study metastasis at a higher resolution. Indeed, metastasis is an evolutionary process that occurs across various organs and timescales, yet its spatiotemporal progression is a black box. To this end, we will use cutting-edge technologies such as evolving barcodes and niche-labelling systems and state-of-the-art in vivo models to identify 1) different spatiotemporally controlled metastatic behaviours, together with 2) the associated alterations in the metastatic niche and 3) specific niche-cancer crosstalk that guides the cancer expansion and metastatic properties. This project will create a first spatiotemporal cellular model of metastasis, which will reveal how the metastatic behaviour at different sites is shaped during metastatic progression. Our research has a long-term ambition to design new therapeutic approaches informed by the metastatic profile and temporal biomarkers in patients.

Keywords: cancer,metastasis,metastatic niche,breast cancer,niche