Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The First Energy Saving Shower Tray with Graphene (PassiveShowerEcoTray)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain,Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2019-02-01
End date: 2019-06-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 2
Project status: CLOSED

The smart-home is a growing market due to customers’ demand. Furthermore, new regulations from the EC coming into force in 2018 and their transposition into national laws, require the use of energy efficient solutions in hot water supply in buildings, which makes this a key market. The shower-tray market alone, estimated in 29M of trays, gives a European market of about €600M in 2018, with a CAGR of 10%. The SME Cerian Shower developed and patented a built-in system for residual heat recovery in shower trays. It consists in a shower tray with a highly efficient heat-exchanger. This facilitates “doit- yourself” installation for end-users and gives agility and lower costs to both end-users and construction companies. With Cerian Shower system, up to 40% of the energy used to warm up water for a shower is recovered. With the collaboration of Graphenano, a SME producing graphene, we will also include graphene in our solution, which we estimate will increase by another 40% the efficiency in energy use. Following the first prototypes developed by Cerian Shower, the company wants to pursue certification product certification in The Netherlands, testing in real settings, and developing further agreements with customers. This will be done during this 5-month SMEInst-1 project. Progressing further in up-scale production via SMEInst-2, Cerian Shower will reach €56M revenues in 2023, and Graphenano will reach €3M revenues in the same year. About 200 new jobs will be generated as a result of full commercialisation of Passive Shower EcoTray in Europe alone.

Keywords: shower plates,shower trays,residual heat recovery
Development of antibacterial compounds that block essential transport function (VitaminBlock)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Netherlands
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-10-01
End date: 2020-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Development of new antibiotics is crucial in future since antibiotic resistance is a rapidly growing problem, which severely threatens our ability to combat infectious diseases. Despite the numerous efforts by International Organisations and Governments, Pharmaceutical companies are reluctant to carry out the costly drug development, as the returns are uncertain and evolving drug resistance weakens their business case further. New solutions are thus called for. We have obtained fundamental insight in the mechanisms and proteins, which mediate uptake of multiple B-type vitamins that are indispensable for bacterial growth. The proteins are the only route for vitamin acquisition in many notorious pathogens such as Staphylococcus aureus and Streptococcus pneumoniae, against which novel antibiotics are urgently needed. Based on our breakthrough crystal structures, we have designed and synthesized molecules that allosterically inhibit the uptake of multiple vitamins. This has led to the discovery of several compounds having potential as antibiotic medicines. What is exciting, our approach enables to target specific pathogens, without affecting many beneficial strains, thereby being effective without causing adverse drug events, which is a major advantage compared to the traditional antibiotics. In the Proof of Concept project, we aim to explore the potential of the compounds for drug development and test them thoroughly, for obtaining important proof for potential partners and investors. In addition, we will carry out pre-commercialisation studies aiming at perfecting the commercialisation strategy, protecting the IP ad well as strengthen the network for the best possible commercialisation outcome. Given the technological and pre-commercial proof of concept will be successful, we are expecting our approach to raise a lot of interest in Pharmaceutical industry, racing to find new ways to tackle the antimicrobial resistance.

Keywords: antimicrobial compounds,medicinal chemistry,gram positive pathogens
Mapping the cosmic expansion history with Type Ia supernovae (EXP-SN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-09-01
End date: 2023-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: SIGNED

Observations of distant Type Ia supernovae indicate that the expansion of the universe is accelerating, driven by a mysterious cosmic component called dark energy. Since the discovery, a standard model of cosmology has been established, wherein ordinary matter only consists of 5% of the energy density, the rest being dark matter (~25%) and dark energy (~70%). Recent, precision measurements of the local expansion rate, the Hubble constant, are in disagreement with the value inferred from the early universe, presenting the strongest challenge to standard cosmology. In this proposal, I will, for the first time, use gravitationally lensed Type Ia supernovae to measure the Hubble constant. Strongly lensed Type Ia supernovae are powerful probes of cosmology since the delay time between their multiple images directly measures the Hubble constant. Wide-field transient surveys like the Zwicky Transient Facility are designed to find tens of such events and hence, it is extremely timely to use them as precision probes in cosmology. Moreover, I will use the Hubble diagram of unlensed Type Ia supernovae in the near infrared to understand the nature of dark energy. Supernova cosmology in the conventional optical wavelengths is limited by systematic uncertainties. Hence, the near infrared is an exciting wavelength regime to improve them as cosmological probes. Type Ia supernovae are more uniform in the near infrared than the optical and there is significantly less extinction from host galaxy dust. Additionally, I will quantify the constraints on dark energy from future experiment, e.g. the Large Synoptic Survey Telescope.
A Universal Acoustic MEMS Gas Sensor with Machine Learning (SmartGas)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Other Widening
Action type: Marie Skłodowska-Curie actions
Countries involved: Türkiye
Call: Widening Fellowships (H2020-WF-03-2020, 2020)
Start date: 2021-05-01
End date: 2023-04-30
Duration (months): 24.0
Total project cost (EUR): 157355.52
EU funding (EUR): 157355.52
Participants: 1
Project status: CLOSED

I am proposing a novel acoustic MEMS gas sensor with machine learning for the first time that can revolutionize the gas sensing field. Gas sensors targeting only a specific type of gas are developed due to the nature of the existing sensing technologies. Current gas sensors either rely on the detection of the electrical property changes upon the reaction of an active material with the gas or infrared (IR) transmission/absorption characteristics of the gases. I am proposing to couple the acoustic resonance in a cavity with a MEMS resonator and use the coupled resonance and damping as a gas sensor. Acoustic frequency and the damping are a function of the gas inside the cavity, and together can be used to detect any gas with machine learning. Since the frequency and damping change with multiple gases in the proposed approach, machine learning algorithms can extract the gas changes in a smart way. Proposed sensor solves the problems of the current gas sensors. It can be manufactured with standard MEMS fabrication flows, can be used with any gas, does not saturate, and has immediate response time. The sensors will be fabricated in the fully equipped clean room UNAM in Bilkent University. I will apply the sensor on human health by working with a pulmonologist to measure CO in human breath and indoor air quality. My supervisor Prof. Hilmi Volkan Demir will guide me throughout the project and help me to improve my technical and soft skills. I will also be able to improve my network and knowledge during my secondment in Fraunhofer EMFT, Germany. Collaborating with Analog Devices and Fraunhofer will be the key for further product technology development. In summary, this fellowship will establish me as a recognized European leader by demonstrating a proof of concept with interdisciplinary research (MEMS, machine learning, and medical application), by patenting and publishing my innovation, and by enabling the path for low cost universal gas sensor productization.

Keywords: mems,gas sensing,acoustic resonance
Modulating Human Subjective Time Experience (ChronoPilot)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Belgium,Greece,Luxembourg
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-09-01
End date: 2025-08-31
Duration (months): 48.0
Total project cost (EUR): 2993965.0
EU funding (EUR): 2993965.0
Participants: 6
Project status: SIGNED

Although time can be measured objectively, human time perception is remarkably subjective and influenced by individual motivations, cognitive states, and social factors. In stressful conditions, we often experience a lack of time, whereas on more relaxing occasions we might lose track of time. On the basis of fundamental knowledge from psychology, ChronoPilot will develop a prototype technology to extend or compress human subjective time adaptively, whenever required. Using mixed reality technologies, people will be presented with visual, auditory, and haptic stimulation patterns that directly or indirectly influence their subjective time. We aim at a comprehensive understanding, through modeling of key parameters and the interplay of the different senses in subjective human time perception. Going beyond individual settings, ChronoPilot will also investigate how to coordinate time plasticity in collaborative settings where the actions of one group member affects the perception of the other members. The research will be validated in two scenarios (precision farming and industrial production), where humans alone or humans and robots have to collaborate in realistic and virtual environments. Such scenarios embed the research in our vision of a future man-machine society where robots have become additional stressors in our daily life that alter our time perception. The improved understanding of the psychology of time perception and the complementing technological means to modulate time will have a profound impact on both technology and society. Time will no longer constitute a passive, constant and immutable factor; instead, it will be a novel focal point around which future socio-technical approaches related to human-human and human-machine interaction revolve.

Keywords: time perception,multisensory perception,mixed reality
Nacht der Wissenschaft in der Kiel Region 2020 (SCIENCE4FUTURE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Germany
Call: European Researchers' Night (H2020-MSCA-NIGHT-2020, 2020)
Start date: 2020-05-01
End date: 2021-01-31
Duration (months): 9.0
Total project cost (EUR): 89775.0
EU funding (EUR): 89775.0
Participants: 1
Project status: CLOSED

Following the huge success of the Researchers NIGHTs 2016-2019, SCIENCE4FUTURE will significantly expand its scope. In 2020, Kiel Region’s 17 research organisations comprising all academic disciplines will be supported by researchers and visitors from neighbouring Denmark, marking the first Danish participation in the ERN since 2009. Together they will showcase their scientists and work to the public not only during the NIGHT in Kiel, but also throughout the year with a series of targeted pre-events across 6 regional cities (Kiel, Rendsburg, Eckernförde, Plön, Preetz and Flensburg). Supported by 40 public, private and non-governmental institutions, it will be the largest regional event dedicated to science. A multifaceted awareness campaign and live broadcasts during the NIGHT will reach 80% of the households. More than 150 activities will give the public a chance to personally talk, work and play with scientists thus breaking down stereotypes. SCIENCE4FUTURE will focus on the themes of Sustainability and Europe, both ideally suited to explain the social, environmental and economic benefits that our researchers achieve every day. Free shuttles buses and ferries will allow visitors (>20,000 expected) to see a broad range of local, national and European research projects in a variety of venues (malls, cinemas, night clubs). A targeted publicity campaign and a fun-filled programme aim at attracting children and young people to participate, including those less interested in academia. Simple “take-home” experiments for teachers, nursery staff and parents will ensure that the interest for research sparked during the NIGHT is kept alive afterwards. Moreover, academic support services (e.g.student admissions or diversity offices) will offer advice on career options. With the strong support of all stakeholders and the active involvement of over 300 researchers in the design and delivery of the programme SCIENCE4FUTURE is set to become a flagship event in Northern Germany.

Keywords: outreach,education,research,inclusion,diversity,sustainability,europe,mobility,teachers,ethics,non formal education,innovation,non governmental sector,public sector,science
NeuroCOGNitive impact of Air pollution exposures in Childhood: Assessment of air pollution effects on the development of cognition and behaviour in children (COGNAC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-09-30
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

Neurological disorders such as Autism Spectral Disorders (ASD) in children are lifelong conditions for which there is no cure,treatment options are very limited AND create huge burdens on children, families and society. Potential long-term consequences of poor cognitive performance and presence of autistic traits are poor social development, low educational achievement, diminished economic productivity and unemployment, mental health issues, and increased risk of antisocial behaviour. In the case of ASD, a lifelong disorder, there is no cure and limited treatment options are available. Therefore, it is essential to identify modifiable risk factors to prevent their onset and prevalence. Air pollution is postulated as a risk factor since it is believed to cause neuroinflammation, oxidative stress and neurodegenerative pathology. Traffic noise shows inconclusive associations with cognitive performance. The experience in cognitive and neurobehavioral development epidemiologic analysis and wide-scale modelling at the host institution, with different modelling approaches and existing models available for UK and London at the partner´s institutions, and the experience of exposure assessment methods of the fellow dovetail nicely to accomplish the goal of the COGNAC project. This is to explore the associations between air pollution and noise with cognitive performance and the presence of autistic traits in children using a large children cohort. The innovative aspects of this proposal are combining multi-pollutant and noise exposure, using very detailed maps of these environmental stressors and assessing effects at critical windows of exposure. The scientific impact of this fellowship results from the identification of the effect of air pollution and noise in cognitive development and the presence of autistic traits in children. The skills acquired in this fellowship will be decisive fo establishing me in one of the leaders in environmental health applied to neurocognition.
A people-centred approach through Self-Management and Reciprocal learning for the prevention and management of Type-2-Diabetes (SMART2D)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Treating and managing disease
Action type: Research and Innovation actions
Countries involved: Uganda,South Africa,Belgium,Sweden,Finland,Sweden
Call: Global Alliance for Chronic Diseases: prevention and treatment of type 2 diabetes (H2020-HCO-2014, 2014)
Start date: 2015-01-01
End date: 2019-12-31
Duration (months): 60.0
Total project cost (EUR): 3344981.25
EU funding (EUR): 3344979.0
Participants: 6
Project status: CLOSED

Background: Type 2 diabetes mellitus (T2DM) and pre-diabetes contribute increasingly to the global burden of disease with the health systems struggling to effectively manage prevention and control. This necessitates contextually appropriate, policy relevant solutions with high scale-up potential. The study is built on a consortium experienced in implementation and cross-cultural translation of disease prevention and management. We aim to strengthen capacity for T2DM care including prevention in high-risk population, through proven strategies like task shifting to community health workers, and expanding care networks through community-based peer support groups. Methods: A phased, participatory approach with built-in on-going policy dialogue will be used for implementing and testing a complex intervention in three countries representing low-, middle- and high-income settings: rural Uganda, urban South Africa and vulnerable immigrant populations in urban Sweden. These actions will follow an iterative process with modifications and improvements within and between the stages of formative research to implementation and evaluation. The testing will be conducted with a controlled design in two arms, a facility-only strategy vs. a combined facility and community strategy evaluated in terms of health systems, disease-related and equity outcomes. Outcomes: The study has a strong social innovations component that will leverage existing networks and platforms, to empower patients, their families and communities through the self-management approach. It will embed research into policy and practice from the beginning; and enable cross-lessons from other chronic conditions and reciprocal learning. It will re-introduce the essential but ‘missing’ community component still existing in low- and middle-income countries back to the health system of a high-income country in a contextually appropriate form, which is relevant for Europe in tackling T2DM and other chronic conditions.

Keywords: self management,reciprocal learning,people centered health systems
IgA-based oral therapy for protection of piglets against infection with enterotoxigenic E. coli. (ImmunoFarm)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-08-13
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

Postweaning diarrhoea (PWD) in pigs is responsible for important economic losses in the global pig rearing industry. This illness is predominantly caused by enterotoxigenic E. coli strains carrying the F4 (ETEC-F4) and F18 (ETEC-F18) fimbriae. There is no treatment available to fight PWD except using antibiotics. However, the prophylactic use of antibiotics is forbidden in Europe and is expected to become forbidden in the rest of the world because of increasing abundance of resistance genes. Delivery of sIgA to mucosal surfaces as passive immunotherapy agent is a very promising strategy to prolong maternal lactogenic immunity against post-weaning infections. The aim of this project is to produce sIgA-like anti-ETEC antibodies in a cost-effective platform. Twenty different anti ETEC-F18 antibodies in a sIgA-like format will be engineered from phage display-selected variable domains (VHHs) currently available in the host institute. The synergistic or additive neutralisation effect of oligoclonal antibody cocktails will be evaluated using ETEC-F18 in vitro villus adhesion assays. The different antibodies will be produced first by transient expression in Nicotiana benthamiana and second in seeds of Arabidopsis thaliana transformants. An in vivo ETEC-F18 challenge will then be performed using two groups of piglets, one receiving the most effective seed-derived feed formulations and the other one receiving regular feed (negative control group). The sIgA antibodies of the elite oligoclonal formulation will then be transferred to biosafe soya seeds as production platform. These steps will lead towards the development of scalable procedures to obtain a cost effective bulk production of a feed based prophylaxis against ETEC.

Keywords: immunoglobulin a,enterotoxigenic e cili,postweaning diarrhea