Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Blending Realities for Interaction across Distributed Group Environments (BRIDGE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Denmark
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 1459998.0
EU funding (EUR): 1459998.0
Participants: 1
Project status: SIGNED

Creative problem-solving in face-to-face collaboration relies on spatiality, which is lacking in current distributed collaboration tools. What if distributed groups could blend their physical spaces to collaborate as if they were face-to-face? Mixed Reality (MR) offers this potential by arranging collaborators’ avatars around shared physical surfaces like desks and whiteboards. Proxemics theory highlights that this spatial arrangement makes collaboration effective. But when distributed space arrangements are dissimilar, it causes spatial incongruencies in collaboration cues, such as pointing gestures. To address this challenge, BRIDGE will develop a novel approach to distributed MR collaboration – Blended Proxemics – that blends people’s real physical surface interactions into a dynamic environment for group collaboration. By supporting MR users in adapting the mapping between surfaces, solutions will be able to scale beyond two users across similar spaces, to groups across dissimilar spaces. Additionally, BRIDGE will address a timely paradox: despite the hype on MR collaboration, we still have no lived experience with how it might change distributed collaboration practices. BRIDGE will establish a novel MR Living Lab to validate the effectiveness of solutions against real work environments with stakeholders. Achieving the goals of BRIDGE requires taking the risk to change both the conceptual, technical, and methodological foundations of the field. Therefore, BRIDGE will (1) develop Blended Proxemics as a new theory for spatial congruency in blended collaboration, providing a taxonomy for researchers to explore solutions, (2) invent new adaptive space mapping techniques and validate their effectiveness for group creativity, and (3) identify real-world barriers to collaborative MR adoption through the Living Lab. BRIDGE results will radically change how we approach distributed MR collaboration research, paving the way for adoption in real-world distributed teamwork.

Keywords: mixed reality,computer supported collaborative work,proxemics
Transforming single-molecule mass measurement by rotating total internal reflection mass photometry (NanoMassPhotometry)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-01
End date: 2027-05-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

We aim to develop a novel label-free optical microscopy approach to transform our ability to characterize and quantify biomolecular dynamics and interactions at the single small-molecule level. The core of the technology, termed rotating total internal reflection mass photometry (RoMP), rests on delivering a step change in label-free detection and quantification of light scattering from individual biomolecules in solution. We will achieve this by leveraging the advantages of total internal reflection to boost optical contrast, and suppress background signatures. This will be enabled for the first time in the context of interferometric microscopy through the use of a specifically-designed optical attenuation optic. Compared to the state-of-the-art Mass Photometry (MP), RoMP will transform the quantitative detection limit and improve mass resolution from ~50 kDa to 10 kDa and from 20 kDa to 2 kDa, respectively. These advances will dramatically expand the range and identity of studies that can be performed by single molecule mass measurement, representing an advance comparable to the change in resolution from 15 to 1.5 Angstrom in cryo-electron microscopy over the past decade. The interdisciplinary and complementary aspects foster two-way transfer of optical nano-imaging knowledge between the applicant (illumination-modulated fluorescence microscopy) and the host (detection-modulated label-free mass microscopy), ultimately catalyzing innovative biochemical investigations and their application by a broad user base for maximum impact.

Keywords: single molecule mass imaging,mass photometry,interferometric scattering microscopy,label free optical microscopy,total internal reflection
CHALLENGES AND INNOVATIVE CHANGES IN RESEARCH ETHICS REVIEWS (CHANGER)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Reforming and enhancing the European R&I System
Theme: Reforming and enhancing the European R&I System
Destination: Reforming and enhancing the European R&I System
Action type: Coordination and support actions
Countries involved: Greece,Croatia,Netherlands,Austria,Italy,Belgium,Germany,Portugal,Norway,Romania,North Macedonia
Call: The future of research ethics review in the changing research environments (HORIZON-WIDERA-2023-ERA-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2879401.25
EU funding (EUR): 2879401.25
Participants: 17
Project status: SIGNED

Trust in science and technology as well as the utility and acceptability of their innovative outcomes is crucially dependent on the ethical qualities of the research. This is the reason why research projects are submitted to an ethical review. Although the existing ethics review infrastructure includes experienced members with expertise in traditional research, this is not the case for new technologies and transformative research that result in new human rights, such as digital rights. Thus, there is a clear need for ethics committees to evolve in order to cover this gap and to be able to support innovation while embedding new human rights. CHANGER aims to promote changes in research ethics reviews that strengthen the capacities of researchers to incorporate ethical judgements in the project design and implementation, and to support ethics committees to address new challenges posed by new technologies and new research practices. CHANGER will review current practices and ethics criteria, will identify and discuss new challenges emerging from new technologies and from new research practices, which are not sufficiently covered in the current review process, will provide innovative training to ethics review experts and researchers, and propose innovative approaches and tools to ethics review reform and new understandings to practice ethics by design, supported by guidelines and a policy roadmap. The CHANGER interdisciplinary consortium has extensive and long-standing experience-based expertise in research ethics reviews, integrity oversight and human rights and is capable of providing novel solutions to the needs in ethics reviews.

Keywords: ethics,ethics review,research ethics committees,ethics by design,new technologies,ai,gene editing,organoids,electronic consent,human rights,training,guidelines,policy making
INTEGRATED CARBON DIOXIDE REMOVAL AND VALORIZATION (CO2REMOVAL)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Estonia
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-06-01
End date: 2024-05-31
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

The world needs outstanding technology and innovative scientific breakthroughs to reach the goal of extracting ca. ten gigatons of carbon dioxide from the atmosphere each year by 2050. Direct air capture (DAC) technology is suitable for offsetting previously over-looked emissions. One cannot overestimate the potential impact of a functional CO2 DAC technology – not only can it help solve environmental problems, but DAC technology can also empower the industry to utilize the captured CO2. The industrial conversion of CO2 into value-added products will cause a slow but steady switch from fossil fuels, turning CO2 from our worst enemy to our best friend. Within the frames of this project, RedoxNRG will develop new electrosorbent materials for the direct air electrocapture of CO2. To advance DAC technology, we suggest augmenting electrocapture with a new class of redox-active and electrically conductive metal-organic materials (ecoMOMs).

Keywords: direct air capture carbon removal metal organic materials mechanochemistry
Building a metabolic atlas of human pluripotency: dissecting the interplay between pluripotency and metabolism in human stem cells. (PLURImet)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 1
Project status: CLOSED

The naïve inner cell mass of the human embryo is characterized by unlimited developmental plasticity as it gives rise to all somatic and extraembryonic lineages. Following implantation, extraembryonic and auto inductive signals prime pluripotent cells for differentiation toward the three germ layers. Concomitantly, metabolic gene expression transits from oxidative phosphorylation towards a glycolytic metabolism. This developmental progression can be recapitulated in vitro using human pluripotent stem cells (hPSCs), a prominent tool for basic and translational research with a great impact on health and economics. Ligands of the JAK/STAT pathway are routinely used for the expansion, generation, and differentiation of naïve hPSCs. In rodents, JAK/STAT signaling controls both pluripotency gene expression and metabolism, but its role in human pluripotency is still unclear. In this project, I will unravel the contribution JAK/STAT pathway to both the transcriptional program and metabolism of human naïve pluripotency. I will study the role of metabolism during the generation, expansion, and differentiation of naïve hPSCs. Moreover, I will produce the first comprehensive computational model of hPSC metabolism to identify metabolic changes associated with human pluripotency transitions. This study is highly interdisciplinary, including scientific expertise encompassing cellular and molecular biology, biophysics, high throughput technologies, and computational biology. The wide scientific and transferable skills training provided by the host institution will allow me to achieve personal and professional maturity, crucial for an independent and competitive scientific career in Europe. The variety of the dissemination and communication measures implemented will definitively ensure maximal reachability to the project, maximizing the scientific and social return of this research.

Keywords: naive pluripotency,jak stat pathway,proliferation,differentiation,oxidative phosphorylation,glycolysis,mitochondria,transcriptomics,metabolomics,in silico modeling
Dynamic engIneered heart tiSsue to Study intEr-individual susCeptibily and improve Treatment of Heart Failure (DISSECT-HF)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Netherlands
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 1998775.0
EU funding (EUR): 1998775.0
Participants: 1
Project status: SIGNED

The objective of DISSECT-HF is to generate engineered heart tissue (EHT) with the use of human induced pluripotent stem cells (hiPSC) from specific forms of heart failure (HF). It focusses on three etiologies of HF with a clear trigger and a large inter-individual susceptibility (pregnancy induced HF, anthracycline cardiotoxicity and PLN cardiomyopathy) to unravel common pathophysiological mechanisms involved in the development of HF. The rationale is: - Better understanding of molecular pathways leading to HF and knowledge about inter-individual susceptibility is needed to improve treatment. - For detection of changes on a molecular level cardiac tissue is needed. - Using innovative experimental approaches, such as dynamic loaded EHT (dyn-EHT), patient specific cells, unbiased target finding and deep phenotyping, I will dissect common disease pathways in the development of HF. SPECIFIC OBJECTIVES: 1. Construction of dyn-EHT from patient specific hiPSC derived cardiomyocytes, endothelial cells and fibroblasts. 2. Generation and deep-phenotyping of dyn-EHT from: A) Females with pregnancy induced HF (susceptible) and siblings with a normal pregnancy (resilience) B) Cancer patients with severe HF after anthracyclines (susceptibility) and patients who could resist high dose anthracyclines (resilience) C) Patients with an early PLN cardiomyopathy phenotype (susceptible) versus elderly asymptomatic PLN mutation carriers (resilience) 3. Identify overlapping and diverse factors. 4. Validate discoveries and apply in unique human cohorts with data on incident HF. WORKPACKAGES: WP1: Optimize construction of dyn-EHT from patient specific hiPSC. WP2: Phenotyping of dyn-EHT from the three HF etiologies focussing on susceptibility and resilience. WP3: Explore the transcriptome and proteome and apply a systems biology approach. WP4: Validate results and explore human relevance in a large cohort with unique phenotyping.

Keywords: heart failure,pluripotent stem cells,disease modeling
Resolving metabolic interactions between the gut microbiota and the host with multi-omics-based modelling (MetaboGutModel)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Integrative B iology : from Genes and Genomes to S ystems
Panel description: For all organis ms: Genetics, epigenetics, genomics  and other ‘omics studies , bioinformatics, systems biology , genetic diseases , gene editing, innovative methods and modelling,  ‘omics for personalised  medicine
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499323.75
EU funding (EUR): 1499323.75
Participants: 1
Project status: SIGNED

The gut microbiota is essential to human health: microorganisms in the human body help to digest nutrients, engage in host metabolism, immunity, behaviour and brain functions. Since the gut microbiota, in contrast to the human genome, can be modified through dietary and therapeutic interventions, modulating the microbiota is a promising path to improve human health and to prevent or treat diseases. However, predicting the effects of microbiota perturbations on the host metabolic phenotype remains extremely challenging due to our limited understanding of bacterial metabolic functions, molecular interactions within microbial communities, and the mechanisms of microbial interactions with the host. I propose to tackle these challenges with a combination of experimental and computational approaches in a synthetic community of 14 common human gut bacteria, which has been associated with > 150 health-relevant metabolites involved in amino acid, vitamin, and hormone metabolism in vivo. We will follow a bottom-up strategy to i) systematically characterize the capacity of single bacteria to consume and produce metabolites of interest and identify the responsible enzymes; ii) investigate the metabolism of these compounds in compositionally diverse synthetic communities; and iii) quantify and modulate microbiota contribution to the host metabolism of these compounds in mouse models. To this aim, we will combine high-throughput bacterial culturing, metabolomics, transcriptomics and proteomics assays with genome-scale metabolic modelling, graph-based multi-omics integration methods and physiology-based models of microbiota-host interactions. This project will provide a generalized framework to systematically resolve microbiota contributions to the host metabolic phenotype, and elucidate the fundamental principles governing microbiota-host metabolic interactions, thus enabling targeted microbiota interventions to modulate the host metabolic phenotype and improve human health.

Keywords: gut microbiota,microbiota host interactions,metabolic modelling,physiology based modelling,multi omics integration
A Novel Understanding of Pandemic Disease in Preindustrial Europe (1300-1800): Combining History, Machine Learning and Natural Sciences (EUROpest)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: United States,Germany,Poland,Latvia,Spain,France
Call: ERC SYNERGY GRANTS (ERC-2024-SyG, 2024)
Start date: 2025-07-01
End date: 2031-06-30
Duration (months): 72.0
Total project cost (EUR): 9999375.0
EU funding (EUR): 9999375.0
Participants: 12
Project status: SIGNED

Born from years of interdisciplinary collaboration, EUROpest aims to articulate the complex ways in which social-ecological systems shape epidemics. It builds on resilience and actor-network theories to advance its own eco-bio-social paradigm that embraces a multi-causal understanding of disease transmission and disease impacts on human societies and ecosystems. While striving to develop and validate a general theoretical model, it takes the well-documented and highly diverse world of late medieval and early modern Europe as its laboratory – investigating its interconnected climatic, cultural, demographic, economic, ecological, and pathogenic history. With regard to the latter, EUROpest assumes malaria, smallpox, tuberculosis and enteric diseases were major components of a disease baseline over which the most devastating disease, plague (Y. pestis), occurred. EUROpest will carry out regional case studies – from Spain to Lithuania, Greece to England – selected on the basis of available and procurable written, scientific and archaeological data. It will holistically consider the contexts of plague outbreaks identified in those regions, to understand how context both facilitated outbreaks and also shaped them, and their short- and medium-term impacts. EUROpest combines archival source analysis with archaeology, archaeogenetics, paleoecology and paleoclimatology, and subjects case studies to novel human-supervised machine-learning to identify the causal role of factors influencing regional outbreaks. As the contemporary imagination is guided in its understanding of epidemic disease by the outbreaks of the past, EUROpest’s contribution will be critical to developing more nuanced and realistic scenarios of future pandemics, academic as well as popular. With EUROpest PIs already engaging policy makers, the mathematical precision of the eco-bio-social analysis EUROpest proposes will help design more successful and targeted interventions for future pandemic response.

Keywords: adna studies,palaeogenomics,environmental history,interdisciplinary history,disease history,climate history,plague,smallpox,machine learning in historical applications
Shift2SDV - a common Software development framework and hardware independent microservice-oriented middleware architecture for the stepwise migration to the Software Defined Vehicle of the Future (Shift2SDV)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: Italy,Spain,Portugal,France,Austria,Germany,Finland,Denmark,Poland,Greece,Romania,United Kingdom,Türkiye,Netherlands,Sweden
Call: Topic 3 Focus topic on “Service Oriented Framework for the Software Defined Vehicle of the future” (HORIZON-JU-Chips-2024-1-IA, 2024)
Start date: 2025-07-01
End date: 2028-06-30
Duration (months): 36.0
Total project cost (EUR): 68428573.74
EU funding (EUR): 19241483.51
Participants: 83
Project status: SIGNED

The Shift2SDV project aims to revolutionize the European automotive domain by creation of an SDV ecosystem around middleware & API framework enabling collaboration across the automotive value chain. This ambitious endeavour envisions a comprehensive shift towards a modular framework that transcends the limitations of current monolithic systems, fostering agility and innovation through the development of complementary middleware services and software development solutions. Central to Shift2SDV is the development of a cutting-edge middleware framework that provides micro-services to build automotive applications upon, abstracting from underlying hardware components – supporting stepwise migration, open source and proprietary components, in-vehicle safety critical and off-vehicle cloud functionality. It is specifically designed to streamline software development and integration while ensuring compatibility and flexibility with existing and emerging technologies. Key technical objectives include the development of a modern, flexible micro-services-based architecture, middleware framework that simplifies the brand-specific application development, and establishment of a safe and secure system architecture compliant with functional safety standards. Additionally, the project aims to develop an orchestration for efficient resource management, integrate edge and cloud computing, and demonstrate the practical viability of the developed middleware through concrete use cases. To maximize impact, Shift2SDV prioritizes active communication, dissemination, and exploitation of project outcomes, fostering collaboration among stakeholders and existing projects and initiatives aligning technological advancements with market demands. Through these concerted efforts, Shift2SDV seeks to propel European leadership in Software Defined Vehicles, driving innovation and economic growth in the automotive industry.

Keywords: sdv middleware and api framework flexible micro services based architecture,