Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PET Imaging of Alpha-Synuclein Fibril Formation (PET-AlphaSy)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany,Germany,Belgium,Sweden,Belgium,Switzerland,Sweden,Netherlands,Netherlands,Netherlands,Denmark,Denmark,Chile,Denmark
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2018-09-01
End date: 2022-11-30
Duration (months): 51.0
Total project cost (EUR): 4100369.95
EU funding (EUR): 4100369.95
Participants: 17
Project status: CLOSED

Too often, physicians have to rely on a trial and error strategy until the most effective treatment for an individual patient is identified. This leads to a critical loss of time, making the healthcare system ineffective and expensive. In respect to drug development, a high failure rate is apparent at all stages of development and ways to reduce this have high priority for the pharmaceutical industry. To this end, drug development and medicinal treatment need to be more personalized and molecular imaging techniques, in particular Positron Emission Tomography (PET) imaging, can be used to achieve this by 1) evaluating the effectiveness of new treatments emerging from the pharmaceutical industry, 2) improving the ability to diagnose diseases, and 3) aid tailoring the treatment based on individual patient pathology. A limiting factor to develop new effective PET imaging probes is the insufficient number of radiopharmaceutical scientists presently available. Our consortium has assembled 6 radiopharmaceutical frontline academic and 10 non-academic partners to address this problem and train the next generation of radiopharmaceutical scientists. Our training will be focused on an unmet scientific need for Parkinson’s Disease (PD). Fibril formation of protein α-synuclein is thought to be the hallmark for PD, but presently, there are no validated PET tracers available for visualization of pathogenic aggregates of this protein. Our scientific goal is to develop such tracer. A successful tracer will have a strong impact on PD-diagnosis and facilitate the development of effective disease modifying treatments. To reach our goals, it is necessary to train our early stage researchers in a highly interdisciplinary fashion spanning from chemistry, over biology, GMP and pharmacy to nuclear medicine. Furthermore, this consortium will train entrepreneurial skills and facilitate start up new enterprises in the current favorable radioisotope market situation.

Keywords: radiopharmaceutical sciences,alpha synuclein,parkinson s disease pd,positron emission tomography pet,molecular imaging you may enter a number of keywords that you consider necess
GridEye Scalable Transactive Distribution Systems (GiSTDS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-12-01
End date: 2022-11-30
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

Coordination of different players in active distribution systems by increasing the penetration of distributed energy resources and rapid advances on the aggregators, microgrids and prosumers with private territory individuals establishes new challenges in control and management systems from the owners’ point of views. Undertaking digitalization of future distribution systems, GiSTDS introduces an edge computing framework based on GridEye, the core production of DEPsys, which provides real time visibility and monitoring. Relevant drawbacks in the distribution system management platforms in handling the scalability of players, look ahead preventive management systems regarding contingency condition and lack of physical boundaries for third party entities (aggregators) will be addressed by GiSTDS. The main novelties of this project in comparison to the GridEye are: 1) Developed P2P trading module provides automated double auction negotiation in real time fashion which enables all private entities with and without specific physical boundaries to participate in local and flexible electricity markets. 2) Modification of GridEye’s modules to address the scalability and resilient operation in both the normal and contingency conditions. 3) To present a look ahead energy managements schemes for the operators, GiSTDS will be equipped to the forecasting module based on auto-regressive with exogenous variables (ARX) and machine learning techniques such as long short term memory (LSTM) and recursive neural network (RNN). Therefore, GiSTDS based on modified and developed modules explores comprehensive distributed framework for control, monitoring and operation of energy systems with multiple dispersed players in different scales. The edge computing solutions in GiSTDS eectively digitalis energy systems and creates major opportunities in terms of avoiding big data concerns and getting a bottom-up monitoring approach for the network supervision.

Keywords: scalable transactive,double auction p2p trading,network supervisory,real time decision making,distributed optimization,forecasting
Evolutionary consequences of novel plant defences (CARDEVOL)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Plant chemical defences play a central role in mediating interactions between plants and their enemies. Phytochemical diversity may be advantageous to reduce herbivore pressure, and plants commonly produce vast numbers of chemicals. However, the diversity of functional classes of defensive chemicals is often more limited and subject to strong phylogenetic constraints. Such functional conservatism may accelerate the evolution of tolerance in specialized herbivores, resulting in plant-herbivore systems dominated by specialists resistant to host plant defences. This presents major challenges for the study of phytochemically-mediated coevolution, as most systems lack the early stages of coevolutionary interactions that are crucially important to predict evolutionary trajectories. Occasionally however, the gain of functionally novel traits allows plants to escape their coevolved herbivores. The genus Erysimum (Brassicaceae) has gained functionally novel cardenolides in addition to ancestral glucosinolate defences, allowing it to escape several glucosinolate-adapted specialists. Making use of the unique natural and emerging molecular resources in this system, CARDEVOL will comprehensively evaluate the ecological, physiological, and evolutionary consequences of novel defences for the plant and its herbivores. CARDEVOL has four main objectives: 1) to characterize the full extent of natural variation in defence of a widespread Erysimum species and to identify environmental drivers; 2) to manipulate both defences and evaluate their contributions to plant fitness in the field; 3) to evaluate tolerance and resistance mechanisms of a community of non-adapted specialist herbivores towards the new defence; and 4), to evolve herbivores under artificial selection for increased resistance. CARDEVOL thus aims at pushing the boundaries of chemical ecology and transforming the field by elucidating the causes and consequences of phytochemical diversification involving gains of function.

Keywords: phytochemical diversification,plant herbivore coevolution,toxin resistance
Setting up Qualification and Continuing Education and Training Scheme for Middle and Senior Level Professionals on Energy Efficiency and Use of Renewable Energy Sources in Buildings (ingREeS)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: Market uptake of energy innovation
Action type: Coordination and support actions
Countries involved: Austria,Austria,Slovakia,Czechia,Czechia
Call: Construction skills (H2020-EE-2014-3-MarketUptake, 2014)
Start date: 2015-03-01
End date: 2018-02-28
Duration (months): 36.0
Total project cost (EUR): 1399622.72
EU funding (EUR): 1399622.72
Participants: 10
Project status: CLOSED

The Project will extend the implementation of the Roadmap established and endorsed under Pillar I Build Up Skills project in Slovakia and the Czech Republic to middle and senior level professionals . These Roadmaps identified key measures for setting up a national qualification and training scheme and other measures for ensuring development of skills essential for the field of buildings to contribute to the fulfillment of the Europe 2020 energy targets. The project will particularly focus on key measure 1.3 and facilitate implementation of key measures 1.1, 1.2, 1.5 and 2.2 of the Roadmap endorsed in Slovakia, and on priority 4.3.1 and measures 1,2 and 4 of the Roadmap endorsed in the Czech Republic. This will strengthen the qualification of professionals identified as target group in the Roadmaps . The project will facilitate further investments in the skills anticipated in the EU Roadmap to a Resource Efficient Europe . Particularly the project will lead to: • Development of 5 education and training programmes for further education and training of middle and senior professionals in the field of buildings; • Setting up permanent network of trainers delivering the training programmes developed under the project; • Training of trainers for delivery of the programmes; • Proposal for financial measures to be established to facilitate and motivate middle and senior level professionals in participating to training programmes and SMEs to invest into further education; • Proposals to Slovak Government for incentives boosting demand for highly qualified professionals; • Reaching financing agreements using ESF for dissemination of training programmes. The project will establish necessary resources and prepare technical, organizational and financial conditions for training and re-training on energy efficiency and use of renewable energy sources for middle and senior level professionals in the field of buildings.

Keywords: use renewable energy sources,qualification scheme,continuing education,construction professionals
Wonder Ants — A new eco-friendly-innovation solution to persistent invasive ants. (WONDANTS)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Italy
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Wonder Ants is a brand new eco-friendly-innovation solution to a very persistent problem: invasive ants. Till today, it was quite impossible to solve the problem of invasive ants unless you used chemical pesticides and even in that case ants came back after a short period. Chemical pesticides, though, represent a threat for natural biodiversity, putting at risk people’s animals’ and pets’ health, and a negative impact on the environment, standing as a crucial pollution factor for natural resources. Unlike baits, Wonder Ants is a revolutionary bio-repellent introducing an original formula based on a well-balanced mixture of essential oils and natural elements that cannot be uncovered, representing a strong inhibitor factor to invasive ants, preventing the environment from pollution and respecting the eco-system. Wonder Ants provides people with a disruptive solution to the problem: the product can be used indoor and outdoor, has a pleasant scent and it is no toxic or hazardous for people, wild animal, pets and plants. And it does not kill ants, but just flee them from the treated environment with a long residual, respecting their valuable role in the planet eco- system. The new product could be applied both in domestic and several industrial contexts, thus meeting some important aims wanted by the European Commission, which provided for the gradual banning of pesticides and toxic components, harmful to the environment, animals and humans.

Keywords: bio repellent,eco friendly innovation,invasive ants,chemical pesticides,biodiversity,environment,essential oils,pollution,anto colony optimization
Photovoltaic with superior crack resistance (PHYSIC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-01-01
End date: 2018-06-30
Duration (months): 18.0
Total project cost (EUR): 149500.0
EU funding (EUR): 149500.0
Participants: 1
Project status: CLOSED

Cracks in silicon solar cells composing photovoltaic (PV) modules are induced during production (soldering of busbars onto solar cells, other defects), transportation, installation and exposure to the environment. The economic impact of cracking in PV modules has been assessed in about 6 Euro/(kWp year) due to the cost of repair/substitution and the missing production while cracks are not yet observable with the naked eye. This has a clear huge technological and economic impact on the market that can be estimated in 180 MEuro/year of losses, by considering a conservative amount of 30 GWp of new installations in the World per year. If cracking cannot be avoided due to the brittleness of Silicon, the proposed idea to be taken to proof of concept is to limit its effect as much as possible. A new generation of PV modules displaying a superior resistance against cracking is proposed, starting from the fundamental discovery within the CA2PVM ERC StG project that residual thermo-mechanical compressive stresses in Silicon cells are beneficial to induce crack face contact and electric recovery. An innovative pre-stressing technique will be designed to increase the residual compressive stresses in Silicon and achieve the crack closure state for any crack and therefore avoid electrical power-losses. An exploitation strategy based on patenting of the technical solution, writing of a business plan, and founding a spin-off/start-up company with a team with interdisciplinary skills will be implemented. This will allow for fund raising and exploitation of the idea also based on the already established industrial contacts.

Keywords: photovoltaics,cracks,durability,optimized residual stresses,innovative pre stressing technique,increase lifetime and energy production
Hybrid Volumetric Optoacoustic-Ultrasound Tomography for Noninvasive Large-Scale Recording of Brain Activity with High Spatiotemporal Resolution (OPTOACOUSTOGENETICS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Germany,Switzerland
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-10-01
End date: 2021-09-30
Duration (months): 60.0
Total project cost (EUR): 1997715.0
EU funding (EUR): 1689061.83
Participants: 2
Project status: CLOSED

Non-invasive observation of fast spatiotemporal activity patterns of large neural populations distributed over entire brains is a longstanding goal of neuroscience. Not only would such abilities significantly promote our knowledge on brain function and its pathophysiology but they are also expected to accelerate development of novel therapies targeting neurological and neuropsychiatric disorders. The progress is hampered by the limited capacity of state-of-the-art functional neuroimaging tools, which do not permit simultaneous monitoring of whole-brain activity with an adequate spatiotemporal resolution. Our recently developed five-dimensional optoacoustic tomography technique is ideally poised to overcome these limitations – it has shown excellent capacity for imaging intrinsic contrast in entire brains of vertebrates and rodents non-invasively; delivers unmatched temporal resolution in the milliseconds range for true volumetric imaging in real time; capable of label-free observations of hemodynamic changes and sensitive to genetic markers of neural activity. Yet, several fundamental challenges ought to be addressed before true potential of optoacoustic functional neuroimaging is unveiled. First, optoacoustic monitoring of fast neural activation under physiologically relevant stimuli and in real disease models has not been achieved. Furthermore, a variety of acoustic effects introduced by the skull compromise performance of optoacoustics in transcranial imaging of murine models, further hindering its clinical translation potential. Finally, technology needs to be developed that can deliver information from single neurons while maintaining high volumetric imaging speed. By resolving those challenges, the current project will yield a unique and groundbreaking functional neuroimaging method that can truly transform the existing paradigms in neuroscience by delivering real time information from hundreds of thousands or even millions of neurons simultaneously.

Keywords: optoacoustic tomography,brain,functional imaging,real time,ultrasound
Bimetallic catalytic arylation of simple arenes (BiMetArylation)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-10-01
End date: 2018-09-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

The development of new methodologies for the preparation of biologically and industrially interesting compounds remains one of the fundamental challenges in chemistry. Aryl-aryl bond formation is one of the most important tools in modern organic synthesis. These biaryl motifs are very often found in pharmaceutical, agrochemicals, organic materials and natural products. Given the abundance of C–H bonds in organic molecules, the selective activation and use of these bonds in controlled synthetically useful transformations is an immensely important topic. In this context, direct C–H arylation has emerged as a powerful methodology for the synthesis of biaryls. However, in most methodologies described so far, the arene substrate must fulfil certain requirements such as containing strong electron-withdrawing or electron-donating groups, or bearing special directing groups. Substrates lacking this feature either are unreactive or must be used in large excess (often as solvents). The coupling of ‘simple arenes’, which are not considered as pi-electron-deficient or -rich remains challenging. The research outlined in this proposal aims at developing a new bimetallic catalytic methodology able to couple equimolecular amounts of ‘simple arenes’ under mild conditions. To do so, we envision a strategy involving a bimetallic double catalytic system. The pi-coordination of the non-activated arene to a metal fragment facilitates the C-H arylation catalysed by palladium complexes which followed by a ligand exchange gives the desired biaryl product, regenerating the initial arene catalyst. The realisation of the objectives of this project would result in a powerful tool for the synthesis of biaryls, coming from simple arenes, improving atom economy, efficiency and sustainability of the reactions, while reducing waste production.

Keywords: c h activation,biaryls,bimetallic catalysis
Co-designed Citizen Observatories Services for the EOS-Cloud (COS4CLOUD)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: EOSC ecosystem
Action type: Research and Innovation actions
Countries involved: Germany,Spain,Germany,Germany,Spain,Greece,Sweden,Colombia,France,Netherlands,United Kingdom,United Kingdom,United Kingdom
Call: Prototyping new innovative services (H2020-INFRAEOSC-2019-1, 2019)
Start date: 2019-11-01
End date: 2023-02-28
Duration (months): 40.0
Total project cost (EUR): 5999055.75
EU funding (EUR): 5999055.75
Participants: 15
Project status: SIGNED

COS4CLOUD (Co-designed citizen observatories for the EOS-Cloud) aims to design, prototyped and implemented services that address the Open Science challenges shared by Citizen observatories of biodiversity, based on the experience of platforms like: Artportalen, Natusfera, iSpot, as well as other environmental quality monitoring platforms like: FreshWater Watch, KdUINO, OdourCollect, iSpex and CanAir.io. The innovative services will be designed, prototyped and implemented for improving the data and information quality using deep machine learning, automatic video recognition, advanced mobile app interfaces, and other cutting-edge technologies, based on data models and data protocols validated by traditional science. The new services will provide mechanisms to ensure the visibility and recognition of data contributors and the tools to improve networking between various stakeholders. Novel innovative digital services will be developed through the integration of CS products, generated by different providers, following open standards to ensure their interoperability, and offered in agile, fit-for-purpose and sustainable site available through EOSC hub, including a discovery service, to both traditional and citizen scientists. The design of new services will be user oriented, engaging a wide range of stakeholders in society, government, industry, academia, agencies, and research to co-design service requirements. As a result, COS4CLOUD will integrate citizen science in the European Open Science Cloud, bringing Citizen Science (CS) projects as a service for the scientific community and society at large.

Keywords: open science,biodiversity,environmental quality monitoring,citizen observatories,eosc,citizen science,big data,cloud services,community based monitoring,artportalen,natusfera,ispot