Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
LEJO: Learned Approaches for Spatial Join Processing. (LEJO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark,Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 2
Project status: SIGNED

Arguably 80% of all data is spatial. This calls for highly efficient and effective spatial data operations. Among them, spatial joins are frequently needed as a key primitive in various applications such as traffic management, robotics control, location-based services and even human brain modelling. However, existing spatial join approaches follow the traditional filter-and-refinement paradigm that is data distribution-oblivious. As a result, existing approaches are increasingly inefficient as spatial datasets to be joined become larger and more complex. The project LEJO is intended to make use of machine learning techniques to better understand the distributions of spatial data, and accordingly design learned approaches for highly efficient spatial join processing. Specifically, the research actions of LEJO include (1) learned approaches for binary spatial joins of memory-resident data; (2) learned approaches for binary spatial joins of disk-resident data; (3) learned approaches for multi-way spatial joins. The research actions will mainly concern analysis of the bottlenecks of existing approaches, design of distribution-aware space/data partitioning, design of learned model based indexes and join algorithms, and implementation and evaluation of the proposed techniques. These research actions, as well as project planning and management, will significantly strengthen the fellow’s research profile and manage skill. This in turn will put him in a considerably better position for future career development after the project. Moreover, a two-way knowledge transfer is expected as LEJO combines the fellow’s expertise in machine learning and the host university’s expertise in spatial data management. Focusing on the challenging intersection of spatial data management and machine learning, LEJO will not only advance the frontier research in the academia but also bring about potential impacts on many spatial data application domains in and beyond Europe.

Keywords: spatial join machine learning ai4db
Investigating opportunities for transformative change in biodiversity conservation: from Big Data analytics to Gamification. (BIOBANG)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Human Mobility, Environment, and Space
Panel description: Human geography, demography, health, susta inability science, territorial planning, spatial analysis
Countries involved: Finland
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1999928.0
EU funding (EUR): 1999928.0
Participants: 1
Project status: SIGNED

Human actions are eroding biodiversity and consequently reducing the contributions nature provides to people. Research has thus far had a strong focus on investigating the direct drivers of biodiversity loss, such as land use change, and their impacts on biodiversity. However, we are still lacking information about how sociocultural, economic, and other indirect drivers affect these direct drivers and consequently biodiversity. A key research priority is to investigate how societal values of nature and human behaviour underpin these indirect and direct drivers and consequently affect the transformative potential for positive and durable changes to human relationships with nature of conservation actions. The project draws from the emerging field of conservation culturomics that takes advantage of digital data sources and methods to study human-nature interactions and employs cutting-edge research methods, including Big Data analytics, video games, and online social surveys, to fill knowledge gaps at multiple scales. By combining social media data and online traditional surveys, it will be possible to understand preferences for species, diverse values of biodiversity, and the sentiment of people experiencing nature. Multimodal analyses of videos and video games will be used to study the potential for behaviour change, including for large carnivore conservation in Europe, and to understand what the diverse motivations supporting pro-conservation behaviour are. Biodiversity footprint calculations and a novel framework for species risk assessment will allow exploring impacts of international trade, culture, and other indirect drivers on biodiversity. Large language models and spatial prioritization will help identify priority conservation actions and areas where they should be implemented. When successful, the project will produce transformational knowledge on diverse perspectives and motivations for actions that can bring about change for biodiversity conservation.

Keywords: digital conservation natural language processing social media data spatial conservation planning
Development of a natural therapeutic treatment for late-stage lung cancer patients (CB24)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator Open 2023 (HORIZON-EIC-2023-ACCELERATOR-01, 2023)
Start date: 2023-10-01
End date: 2026-07-31
Duration (months): 34.0
Total project cost (EUR): 3855337.5
EU funding (EUR): 2499999.0
Participants: 1
Project status: SIGNED

Celtic Biotech Ireland has developed CB24(Crotoxin). A naturally derived receptor binding protein, delivered as monotherapy at home using infusion pumps, is hailed as a life changing treatment of Non-Small Cell Lung Cancer (NSCLC). Delivered intravenously, CB24 induces predictable and consistent apoptosis (cell death) and autophagy (degradation) in human lung carcinoma cells. CB24 outclass the competitive NSCLC treatment solutions (surgery, chemotherapy, and radiotherapy) through its efficacy, safety, minimal side-effects, easy to use home based treatment and suitability for all patients including those at stage 3 & 4. Celtic have already proven the efficacy of CB24 through pre-clinical and FIH clinical trials. Through the proposed 24months EIC project, the company aims to undertake Phase I Part 3 clinical trials involving 24 patients with the ultimate goal of garnering the regulatory approvals (EMA, FDA) to market the drug as a verified cancer therapeutic.

Keywords: snake venom,intravenously administered drug,crotoxin,late stage cancer treatment,cancer treatment,non small cell lung cancer nsclc
Non-linear Existential Arithmetic Theories (NEAT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 1
Project status: SIGNED

Arithmetic theories are logical theories about systems of numbers that found important applications in several areas of computer science. For instance, those theories have a fundamental role in Satisfiability Modulo Theory (SMT), abstract interpretation and symbolic execution, the three most prominent algorithmic techniques to type check or bug test programs against rich specification languages. In optimisation, Integer Linear Programming offers a general framework to model many scheduling, planning and network problems using linear integer arithmetic. In Theoretical Computer Science, several computational problems stemming from formal logic and automata theory require arithmetic theories procedures to be solved. Arithmetic theories are simple to describe, but their algorithms are based on profound mathematical theories. The goal of this proposal is to achieve a major advance in algorithms for decision and optimisation problems of existential arithmetic theories featuring the non-linear operators of exponentiation and divisibility. We choose to focus on these two operators for both theoretical and practical reasons. On the theory side, whereas multiplication often causes decidability issues (see e.g. the undecidability of Hilbert’s 10th problem), exponentiation and divisibility are much more algorithmically robust. On the practical side, these two non-linear operators have recently found several applications in the aforementioned areas of computer science. To achieve our goal, our methodology combines several areas of mathematics and theoretical computer science: automata theory, combinatorics, non-convex geometry, model theory and number theory. While the content of the proposal is foundational in nature, the long-term goal is for algorithms developed during the project to serve as a basis to expand the capabilities of SMT solvers, static analysers and optimization tools, making them able to handle very expressive languages of arithmetic.

Keywords: arithmetic theories,mathematical programming,non linear optimization,decision procedures,computational logic
Photoswitchable Supramolecular Polymer Networks. Toward Spatial and Temporal Control of Self-healing Function (LightHeal)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-12-01
End date: 2026-11-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

Self healing polymers, i.e., materials which the ability to repair themselves, have emerged as an attractive alternative to traditional materials due to the advantages they offer to society in terms of durability, reliability and cost and energy efficiencies. A fruitful approach towards these novel materials is based on the introduction of supramolecular cross-links into polymer frameworks, which, due to their reversible and dynamic nature, can be dissociated and reconnected multiple times to heal the damaged area. However, polymer toughness and autonomous healing exhibit an inverse relationship and, for practical reasons, the healing process must be activated in conditions that are different from the working conditions, or otherwise the material becomes too soft. Such activation is typically carried out through thermal heating, which accelerates the dynamics of the non-covalent bonds and enhances polymer chain diffusion. In LightHeal we plan to make a groundbreaking impact in the field of dynamic polymer networks by developing phtotoswitchable supramolecular cross-links that exploit the extraordinary attributes of Light as an external stimulus. Concretely, we want to be able to switch on/off cooperative noncovalent cross-links in polymer networks, so that the material can reversibly alternate, on demand, between a mechanically tough state and a soft, healable state. Moreover, we want to achieve such control with spatial precision, temporal precision, and wavelength orthogonality. For such goal, we will combine the knowledge of the host group in G-quadruplex polymer networks with the experience of the candidate in state-of-the art azobenzene photoswitches. LightHeal introduces fundamental challenges and unprecedented approaches in the expanding field of stimuli-responsive polymer materials with “smart” functionalities, and constitutes the best research scenario for the candidate to learn from different fields and further develop his career.

Keywords: supramolecular polymers,g quadruplexes,photoswitches,self healing materials
New Space for the Extreme Right. An Alternative History of Western Europe in the Early Phase of the Cold War (1945 to mid 1950s) (NEXTRIGHT)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-06-01
End date: 2026-05-31
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 1
Project status: SIGNED

NEXTRIGHT illuminates how Western European democracies dealt with and were impacted by the re-emergence of fascism and, more generally, the extreme right, in the immediate aftermath of World War II (from 1945 to the mid-1950s). These years were marked by the early stages of the Cold War which encouraged some governments to adopt anti-communist measures, but that season was also signed by the re-emergence of a renewed threat, that posed by the extreme right. The latter maintained its strength and economic resources in many Western European countries (beyond the right-wing Portuguese and Spanish dictatorships) as attested by the foundation of new parties, periodicals and transnational networks. Yet, this side of post-1945 Western European history is often underestimated. NEXTRIGHT reverses this trend by investigating how democratic governments in Western Europe responded to the renewed extreme-right activism, relocating this issue within a broader narrative of post-1945 Western European history. Finally, it assesses whether the Cold War context played a role in conditioning the approaches of governments and in what terms the initial phase of decolonisation influenced the revival of the extreme right. In an era when democracy seems particularly fragile, democratic governments are reconsidering their approaches to confronting extremist movements, NEXTRIGHT, therefore, underscores the importance of developing comprehensive responses to such delicate issues, which are associated with profound ethical questions (for example, whether it is right to tolerate the intolerant). NEXTRIGHT is a multi-archival research focused on four case studies, namely those of France, Italy, Switzerland and the United Kingdom. The aim is to explore and compare the national debates and measures undertaken in each country and to investigate the response of the fascists, who developed a narrative that allowed them to continue to influence the European public sphere.

Keywords: post 1945 fascism extreme right democratic cultures western european history cold war studies history of the circulation of political ideas freedom of expression militant democracy
Decarbonizing energy: Mapping and modelling the global energy sector's Asset owners, investment choices, technological pathways, and Political influence (MAP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 226420.56
EU funding (EUR): 226420.56
Participants: 1
Project status: SIGNED

The urgent need for rapid decarbonization of the global energy sector to meet Paris Agreement goals requires more robust policies based on a deep understanding of the sector’s key economic actors, investment decisions and incentives, and influence on policymaking. However, these factors have not yet been thoroughly studied. The MAP project addresses this critical research gap by examining, at the global level, primary energy supply firms' physical investment, categorized by technology - dirty, clean, or options like CCS potentially diverting resources from cleaner alternatives. These investments will be traced to the firms’ ultimate owners, whether governments or shareholders. Additionally, MAP will analyze how ownership, control, and board structures influence energy and climate policies. Ultimately, the project aims to identify the most effective policy mixes for achieving rapid decarbonization of energy, considering these dynamics. MAP will employ empirical, econometric and network analysis to study investment patterns, ownership structures, and their influence on climate and energy policymaking. It will also develop an agent-based model to simulate policy scenarios and assess policies' effectiveness. The project will provide insights into energy decarbonization's industrial and political economy dimensions by integrating economics, network analysis, energy system modelling, and political science. Hosted at UniCA within a leading multidisciplinary research group and supervised by Prof. Mauro Napoletano, an expert in agent-based models and network analysis, the project will produce cutting-edge research. The fellow, expert in climate economics, innovation, and concentration, will contribute to the group's research and knowledge exchange. This fellowship will broaden the applicant's expertise, research capabilities - enhanced through advanced courses at UniCA - and professional networks, positioning her for a tenured role at a leading EU institution.

Keywords: decarbonization primary energy supply political influence agent based modelling ownership and control networks
Tackling the limits of pertinent material properties of wafers and photonic devices based on epitaxial barium titanate thin films (PHOENIX HopOn FZU)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Belgium,Czechia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 8.0
Total project cost (EUR): 201125.0
EU funding (EUR): 201125.0
Participants: 2
Project status: CLOSED

The goal of the HopOn partner FZU is to contribute in tackling the limits of pertinent material properties of wafers and photonic devices based on epitaxial barium titanate thin films integrated on a silicon platform. To this end, we will use broadband dielectric measurements with emphasis on the phase-sensitive terahertz time-domain spectroscopy. The experiments will be supported by computational studies of lattice dynamics and domain walls in barium titanate using atomistic and phase field modelling. Such a comprehensive research strategy will allow bringing an important feedback to optimize the novel Phoenix technology. As a member of the consortium with forefront industrial and academic players in the field of photonics, FZU will expand its know-how on the knowledge transfer to industry, enlarge its network of collaborators and acquire experience for new participations in joint EC projects.

Keywords: photonic devices dielectric measurements barium titanate epitaxial silicon terahertz time domain spectroscopy atomistic and phase field modelling
Astrovalues of Work at the Observatories in Kazakhstan (AWOKAZ)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

Space exploration is driven by work and values. AWOKAZ investigates the role of work and values in creating, maintaining and disrupting social relations in and around the observatories and laboratories of the Fesenkov Institute of Astrophysics (FAI) in Kazakhstan. The research aim of AWOKAZ is to advance understanding of how astronomers, herders and tourist guides value and construct their lives in relation to space and space research infrastructures. "Astrovalues" in this research are the multifaceted economic, imaginative and moral forces that motivate actors' everyday practices of engagement with cosmic events and processes. These diverse forms of engagement include, but are not limited to, scientific passions of abstraction, touristic forms of commodification and consumption of the night sky, and various relations to the stars as guides or mythological figures. The project will provide a robust analysis of how the work of astronomers, guides and shepherds is mediated by the economic forces of the free market as well as the moral socio-cultural values of relating to cosmic processes. AWOKAZ will focus on the histories, contemporary practices and biographical trajectories of the astronomers, tour guides and shepherds who live and work in or around the astrophysical observatories of the Fesenkov Astrophysical Institute (FAI).

Keywords: social studies of outer space,central asian studies,infrastructure studies,anthropology of value,infrastructure studies
Linking metabolism and RNA biology in neurodevelopment through a new pathway (MetaboSplicing)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: CLOSED

Neurodevelopmental disorders (NDDs) affect 3-8 percent of children across Europe and cause a life-long alteration of cognitive abilities or social interactions with little therapeutic possibilities. Recent studies have uncovered that dysfunctional mitochondria and metabolism are involved in NDDs like intellectual disability and autism spectrum disorder. Notably, neuronal circuit development, a crucial process during the formation of the brain, is characterized by an increase in metabolic activity supporting a period of intense remodelling. However, the knowledge of molecular processes controlling metabolic homeostasis during neural circuit development is still incomplete. We recently defined the autism-associated kinase NUAK1 as a critical regulator of local mitochondrial metabolism in neurons, supporting axon morphogenesis. However it is not clear how NUAK1 controls metabolic processes in neurons. We have identified a novel substrate of NUAK1 and hypothesize that NUAK1 controls an alternative splicing program through this new interactor, thereby regulating metabolism, which in turn affects neuronal development. We will: 1. Perform a phenotypical characterization of the novel substrate’s role in developing neurons in vitro and in vivo; 2. Investigate its effect on neuronal and axonal metabolism; 3. Characterize its associated transcriptomic signature in developing neurons; and 4. Assess the role of NUAK1 in controlling its novel substrate functionally. For this, we will use state-of-the-art techniques like microfluidic devices and deep-sequencing of mRNA. This ambitious project aspires to describe a new cellular pathway, integrating RNA biology and metabolism in developing neurons and will provide the first characterization of a novel interactor of NUAK1 and its control by the latter in developing neurons.