Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mechanisms of co-translational assembly of multi-protein complexes (CoTransComplex)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Netherlands,Switzerland
Call: ERC Synergy Grants (ERC-2022-SYG, 2022)
Start date: 2023-04-01
End date: 2029-03-31
Duration (months): 72.0
Total project cost (EUR): 9458525.0
EU funding (EUR): 9458525.0
Participants: 3
Project status: SIGNED

Most proteins function within larger complexes. How these intricate structures are correctly formed is poorly understood, yet critical to all cellular processes and pathological conditions. Recent breakthroughs suggest that multi-protein complexes form co-translationally, by super-assemblies of multiple ribosomes and other cofactors that are coordinated in time and space. This striking notion contrasts starkly with textbook models and is key to the possibilities and failures of complex formation. However, owing to technical limitations, the mechanisms and scope of actively coordinated protein assembly are poorly understood. Elucidating how these large and transient co-translational formations produce protein complexes throughout the genome is a next-level challenge that cannot be addressed by a single discipline. We propose a unique merging of cutting-edge approaches: 1) Ribosomal profiling to detect interactions between ribosomes engaged in assembly and cofactors genome-wide, 2) Single-molecule force spectroscopy and super-resolution imaging to reveal ribosome movements and nascent chain assembly. 3) Cryo-EM and tomography to elucidate the structural basis of ribosome interactions that enable direct assembly. Our program addresses 1) the coordination of multiple ribosomes in time and space, 2) the folding and assembly of nascent chains, and guidance by chaperones and novel cofactors, 3) the major protein complexes classes of homo-dimers, higher-order oligomers, hetero-dimers, and complexes formed at membranes. This ambitious program will provide insight of unprecedented detail and scope, spanning from the cellular to the atomic level, from in vivo to in vitro, from genome-wide patterns to molecular mechanisms, and from bacteria to human cells. It will impact a vast spectrum of protein complexes, reveal unknown layers of control in protein biogenesis, with implications for ribosome quality control, artificial protein design, and mechanisms of disease.

Keywords: co translational protein folding and assembly,translation,ribosomes,chaperones,cryo em,single molecule biophysics,ribosome profiling
A direct photocatalytic access to chiral β2-amino acids from alkenes using CO2 as the carbon source (SYNERGISTIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-08-01
End date: 2025-07-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 2
Project status: SIGNED

The development of enantioselective strategies is becoming highly important as the global chiral chemicals market is expected to reach 120 billion USD by 2025. Among these chiral molecules, β2-amino acids and their derivatives are highly demanding chemicals because of their extensive uses in the synthesis of pharmaceuticals. My SYNERGISTIC proposal will envisage the functionalization of challenging alkenes and CO2 to achieve chiral β2-amino acids under energy-efficient photocatalytic conditions. To achieve this chemistry, I propose a novel approach by employing two different catalysts to activate simultaneously the double bond of alkene and to insert CO2 into the double bond. I will use a metal-free photocatalyst in combination with a halogen atom transfer (XAT) reagent to activate the double bond of alkene, and a homogeneous chiral transition metal complex to insert the CO2 molecule in a face-selective way. The mild reaction conditions of photoredox catalysis should enable to functionalize a wide range of alkenes as well as for late-stage functionalization of ‘functionally challenging’ molecules found in natural products and complex pharmaceuticals. This proposal will significantly contribute to the advancement of the ‘CO2-valorization’ blueprint as well as will create a groundbreaking ‘green approach’ for the synthesis of chiral β2-amino acids using CO2 as a C1 synthon. More importantly, the fundamental new insights of this novel catalytic system that will be gained during this investigation will be a game-changer for the enhancement of sustainable chemistry.

Keywords: photocatalysis,co2 chemistry,chiral ni catalysis,late stage functionalization,flow chemistry
EARLY COLORECTAL CANCER: PATIENT-TARGETED AND ORGAN PRESERVING TREATMENT ECOPOP (ECOPOP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Norway,Poland,Belgium,Germany,France,Italy,Sweden,United States,Spain,Switzerland
Call: Comparative effectiveness research for healthcare interventions in areas of high public health need (HORIZON-HLTH-2024-DISEASE-03-two-stage, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 7183718.21
EU funding (EUR): 6999931.25
Participants: 18
Project status: SIGNED

Incidence and mortality of colorectal cancer (CRC) is the second leading cause of cancer death in Europe. With current screening programs in most European countries, many CRCs are detected in an early and curable stage with excellent prognosis. The current standard treatment for early CRC is surgical tumour removal. This is considered as overly invasive especially for the growing number of elderly and frail patients. Expanding technical possibilities of local tumour removal by flexible endoscopy along with initial data supporting its oncological safety open the way to organ preserving therapy. This may result in avoiding surgery and improved patients´ quality of life (QoL). However, high-quality, long-term oncological outcome data of endoscopic removal as compared to surgery are lacking, and precise oncological risk criteria prior to the start of the therapy are urgently needed. The current project has two major aims: a) to assess oncological efficacy, safety, and patient QoL of local endoscopic removal of early CRC as compared to surgery in 3 randomized trials, and b) to develop and test criteria in this patient population to primarily identify high-risk lesions based on novel biomarkers, endoscopic imaging, and other clinical criteria, also within an artificial intelligence-guided treatment algorithm. We propose to provide state-of-the-art assessment of new, sustainable, less invasive treatment modalities for early-stage CRC and determine patient preferences around these therapies. We will perform large, international head-to-head randomized clinical trials. These trials will allow carbon cost effectiveness analyses, biomarker research and development of clinical practice guidelines to carve out the next-generation best clinical practice for patients with early-stage CRC. Our proposal aims at less invasive, sustainable organ-preserving therapies maintaining high oncological efficacy and helping physicians and patients to perform individual shared decision-making.

Keywords: colorectal cancer endoscopy surgery quality of life
Optical Camera Communication For SATellites (OCC4SAT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Spain,Italy,France,Switzerland
Call: Future Space Ecosystem and Enabling Technologies (HORIZON-CL4-2023-SPACE-01, 2023)
Start date: 2024-01-01
End date: 2026-06-30
Duration (months): 30.0
Total project cost (EUR): 1987375.0
EU funding (EUR): 1619125.0
Participants: 5
Project status: SIGNED

OCC4SAT aims to develop an enabling communications technology for the space industry, providing a solution to some current needs of the space sector, such as the intra-satellite communication links and the reduction of the dry mass of data transfer cables, connectors, and shielding. The project proposes the integration of Optical Camera Communications (OCC) into the intra-satellite environment providing the flexibility of this technology for enabling new unprecedented flexible design opportunities thanks to the inherent spatial multiplexing capabilities of OCC, its cost efficiency, and the possibility of grasping reflections on the inner walls (and objects) of the satellite to establish NLOS links. OCC4SAT addresses Area 2 of the call. The project will provide two main technology demonstrators (which will be discussed in more detail in the Implementation section): (i) an intra-satellite OCC network simulator that could serve as a tool for speeding up satellite design while providing performance estimates and (ii) a physical demonstrator based on a satellite mock-up able to showcase the flexibility, robustness, and performance provided by the OCC technology. The project's main objectives are a link range of around 1 m suitable for the mini satellites, a data rate above 3 kbps enough for the satellite operation, or a mass below 300 g using lightweight COTS cameras and discrete LED devices, to name a few. OCC4SAT will address several relevant challenges related to both the space and communications fields, such as the limited power supply, weight, space, and clearances in smallsats, or the high spatial multiplexation order of the OCC nodes, the increase of the data rate and the developed of links based on reflections on the payload surfaces, among other.

Keywords: optical camera communications,occ,intra satellite communications,harnessing reduction
AI-based Total-Carbon-Footprint for a low-carbon European manufacturing sector (TCF - Tanso Total Carbon Footprint)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Challenge: Technologies for ‘Fit for 55’ (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 4234903.75
EU funding (EUR): 2499999.0
Participants: 1
Project status: CLOSED

To date, we have developed Tanso, an AI-powered automated carbon accounting software that enables industrial companies to calculate and report their carbon emissions accurately and efficiently. Our ISO14064 and GHG Protocol compatible CCF calculation uses available primary data mapped with our 13k emission factor database, completing it through a supply chain model of industrial averages. We have a unique data foundation to break down corporate emissions onto product level and have developed a user-centric statistical allocation model where users can set up an interpretable digital twin of production processes and allocate the right emissions per product line. Our goal is to achieve standard-compliant PCF estimations at scale. Through the probabilistic approach, we provide transparency on data quality, incentivizing companies to improve primary data sources and initiate effective carbon reduction initiatives, and providing reliable information to stakeholders.

Keywords: advanced computing,automation,e learning,user modelling,collaborative systems,environmental protection,corporate social responsibility,supply chain management
TRANSOPP - The Dynamics of Transnational Support to Opposition Movements in Lebanon and Iraq (TRANSOPP)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-09-01
End date: 2028-08-31
Duration (months): 24.0
Total project cost (EUR): 193643.28
EU funding (EUR): 193643.28
Participants: 1
Project status: SIGNED

In my research project, I aim to investigate the inter- and transnational dynamics of opposition to regimes in ethno-religiously divided societies, with a specific focus on how groups within the Lebanese and Iraqi diaspora populations contribute to challenging the regimes in their countries of origin. By uncovering novel aspects of diaspora communities’ role as drivers of change, the project will provide significant contributions to the scientific debates on increasing stability, prosperity, and democratic accountability in countries with a history of sectarian conflict and authoritarian rule. Furthermore, it will generate relevant knowledge for policymakers and EU institutions on how to engage diaspora communities in promoting stability in the Middle East during times of increased unrest. So far, most studies of Lebanon's and Iraq's diasporas have focused on how these communities challenge regimes in their countries of origin through direct forms of activism such as mobilizing expat voters or organizing solidarity demonstrations in support of anti-regime uprisings. Less is known about how they use initiatives, such as social entrepreneurship, cultural engagement, reconstruction, and charity work, to exercise more indirect forms of oppositional engagement. Given the limited success of direct political campaigns, these indirect forms of engagement provide an alternative way to achieve impact. The project seeks to uncover the nature, potential, and significance of indirect oppositional diaspora engagement.
Scaling Up secure Processing, Anonymization and generation of Health Data for EU cross border collaborative research and Innovation (SECURED)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Maintaining an innovative, sustainable and globally competitive health industry
Action type: Research and Innovation actions
Countries involved: Netherlands,Hungary,Spain,Belgium,France,Greece,Ireland,Italy,Cyprus
Call: Scaling up multi-party computation, data anonymisation techniques, and synthetic data generation (HORIZON-HLTH-2022-IND-13, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 6999723.75
EU funding (EUR): 6999723.25
Participants: 18
Project status: SIGNED

The overall goal of the SECURED project is to scale up multiparty computation, data anonymization and synthetic data generation, by increasing efficiency and improving security, with a focus on private and unbiased artificial intelligence and data analytics, health-related data and data hubs, and cross-border cooperation. The project will address the limitations that are currently preventing the widespread use of secure multiparty computation and effective anonymization, namely: the limited practical capabilities of current cryptographic schemes for secure multi-party computation protocols, and their performance; the lack of well understood and standardized data anonymization methods for health data; the absence of dynamic and on demand services for generating synthetic data; the complex and ad-hoc nature of current federation protocols for machine learning and AI-based data analytics; the lack of support for health technology providers to implement privacy enhancing technologies, in particular SMEs. SECURED will tackle these challenges by focusing on scaling up privacy technologies via algorithmic improvements and implementation efficiency (HW and SW), as well as the generalization of primitives and definitions, with the aim of speeding up and facilitating privacy preserving data-driven tools and services for wellbeing, prevention, diagnosis, treatment and follow-up care. SECURED will also analyse the current ethical and legal challenges to data sharing, and is targeted at overcoming current limited adoption of advanced multi-party computation and data anonymization technologies by providing direct support to health technology SMEs through a funding call. To ensure relevance to real-world settings, SECURED will showcase the technologies developed in four health-related use cases provided by partner hospitals and health stakeholders, namely: real-time tumor classification; telemonitoring for children; synthetic data generation for education; access to genomic data.

Keywords: anonymization,synthetic data generations,multi party computation federated learning
Impacts of antibody cross-reactivity on gut community ecology and vaccine immunogenicity (SUGAR)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-08-01
End date: 2027-07-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

Antimicrobial resistance (AMR) is a looming global threat, rendering antibiotic treatments useless, and making bacterial infections difficult to treat. With diminishing antibiotic options to control infectious outbreaks, we must develop new strategies to prevent widespread mortality. Our group develops novel vaccines to leverage the body’s natural immune responses to fight bacterial infections. To do this, it is crucial to understand how our immune systems recognize harmful bacteria (“pathogens”), and how they distinguish them from the ‘good’ gut-resident microbes which promote human health. Oral vaccines typically induce protective immune responses which recognize sugar structures on the outer membrane of harmful bacteria, promoting their elimination. However, some of these sugar structures use the same molecular building blocks as those found on the surface of beneficial bacteria. In fact, some pathogens mimic the sugar structures of beneficial microbes to evade the immune system. In turn, this may lead to inappropriate recognition of good bacteria by the immune system. I plan to combine vaccination studies in mice with molecular tools to study direct surface sugar-immune interactions, focusing on immune responses to World Health Organization AMR priority pathogens Salmonella and Shigella. I will answer fundamental questions about immune-bacterial recognition: (1) Can immune antibodies induced in response to harmful pathogens also recognize good bacteria? (2) Does this recognition impact the composition and host-beneficial functions of gut resident microbial communities? (3) Does non-specificity of bacterial immune targeting reduce vaccine-mediated protection? Outcomes will contribute to fundamental scientific knowledge of immune-bacterial interactions and provide valuable public health insights, including explaining individual variation in vaccine protectiveness. Ultimately, this work will inform the design of effective human vaccines to combat AMR.

Keywords: glycobiology immune bacteria recognition surface glycans commensal microbiota pathogens microbial ecology infection dynamics vaccination cross reactive antibodies immunoglobulin a iga seq
Longitudinal multi-omic profiling to provide a molecular map of human stroke (MAP-STROKE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 202125.12
EU funding (EUR): 202125.12
Participants: 1
Project status: SIGNED

Stroke is a leading and increasingly important cause of death and disability in the EU. Yet, we have only few effective treatments and an unsatisfactory understanding of human stroke pathophysiology. Current diagnostic algorithms fail to capture pathophysiological mechanisms in daily clinical practice, hindering the allocation of patients to treatments and the development of novel therapies. While stroke care algorithms rely on clinical and single-timed imaging assessments, thousands of proteins and metabolites circulate within the blood representing a neglected window into our body. With MAP-STROKE, I aim to leverage serial multi-omics, longitudinal imaging, and deep clinical phenotyping data from the recently completed PROMISE study (N>500) to create a molecular map of human ischemic stroke and to identify novel clinically meaningful molecular biomarkers. By combining multiple unique project features including i) a novel molecular conceptualization of stroke, ii) the integration of genomic, proteomic and metabolomic data, iii) high-frequency serial assessments, iv) longitudinal imaging and phenotyping, and v) novel bioinformatics methodology including multi-omic factor analysis, MAP-STROKE goes considerably beyond the current state-of-the art and will advance personalized medicine in stroke. The MSCA fellowship under the mentorship of Dr. Steffen Tiedt at the Institute for Stroke and Dementia Research at LMU Munich would give me the exceptional opportunity to apply and expand my bioinformatics expertise in molecular modeling towards more complex multimodal biomedical data and to develop the skillset needed to become an expert and eventually independent group leader in medical bioinformatics in Europe. I envision the identified molecular biomarkers to drive precision medicine in stroke and to reduce its societal and economical burden.

Keywords: stroke,muti omics,molecular map,proteomics,metabolomics