Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Advanced analysis of multiparametric volumetric ultrafast ultrasound: a novel approach for non-invasive breast cancer diagnosis (MUSCAD)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 1499498.0
EU funding (EUR): 1499498.0
Participants: 1
Project status: SIGNED

Tumour development follows a diversity of complementary biological pathways, including the modification of the tissue structure and vascularization, which are not currently captured by imaging techniques in the clinic. Breast cancer patients undergo a series of imaging sessions using complementary modalities, including ionizing mammographies. In many cases, this imaging is not precise enough for a diagnosis, so that tissue samples in the form of biopsies are used to further characterize the tumour and determine the appropriate treatment. Beyond the pain and stress associated with biopsies, this complex process is costly and time consuming, and delays the time to diagnosis. Ultrasound B-mode imaging is largely used in the diagnostic process of breast cancer, in part because it is low cost, portable and largely available, as well as non-ionizing and non-invasive. Our laboratory, Institute Physics for Medicine Paris has recently developed several quantitative techniques allowing for the measurement of tissue stiffness, fiber organization, and vascular mapping, all relevant to tumour development. In this project, I propose a new approach to diagnosing breast cancer non-invasively by applying machine learning analysis to rich volumetric multiparametric maps of complementary tumour aspects, obtained using these innovative ultrafast ultrasound techniques. The project will tackle the technological challenge of integrating these techniques into a common acquisition and analysis framework, and include the collection of a large clinical dataset and the development and validation of a predictive malignancy model informing on tumour characteristics for the diagnosis. This approach will open the door to fully virtual biopsies, impacting society on a large scale in terms of cost, diagnostic efficacy, and patient comfort.

Keywords: machine learning,predictive models,breast cancer diagnosis,ultrafast ultrasound imaging,3d ultrasound imaging,ultrasound biomarkers
Alternative Water Resources and Deliberation process to renew water supply strategic planing (AWARD)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Land, ocean and water for climate action
Action type: Innovation actions
Countries involved: France,Germany,Romania,Spain,Greece,Italy,Cyprus
Call: Improve the reliability and effectiveness of alternative water resources supply systems and technologies (HORIZON-CL6-2023-CLIMATE-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 3690612.5
EU funding (EUR): 3405762.5
Participants: 16
Project status: SIGNED

AWARD recognises the urgency of action due to water scarcity and climate change impacts as well as the need to engage simultaneously the society, the science and the policy into the development of knowledge and strategic water planning. Therefore, AWARD will provide evidence-based solutions to consider AWRs into water supply strategic plans, based on socio-political engagement. The 4 Demo Cases of AWARD are already implementing AWRs (storm water, rainwater and aquifer recharge in Bucharest in Romania as well as in Milano in Italy; water reuse in Cyprus, storm water and rainwater in an industrial park in Santiago di Compostel in Spain). Through the project activities, Demo Cases will consider scaling up their actions taking in account a broader range of AWRs together with conventional water resources for planning future water supply systems at local or regional level using AWARD instruments (Local Water Fora, Digital Platform for decision making, training and guidance). They will address similar issues in a harmonised and coordinated way. Societal awareness to support the decision process on AWRs supply solutions will lead to the recommendations for further use of AWRs encompassing the 4 dimensions of social innovation (Technological, Capacity development, Governance & Policy, Economics & assessment). The AWARD AWRs catalogue will gather the project results and additional solutions which will be benchmarked. The digital platform provided by AWARD will support the exploration of resilient scenarios that will be promoted beyond the scope of the project thanks to dedicated networking activities. AWARD general objective is to provide evidence-based knowledge and lessons learnt on how to effectively integrate affordable, acceptable and reliable AWRs solutions into water supply strategic planning and implementation considering the effect of global changes.

Keywords: non conventional water resources,reuse,artificial recharge,storm water,rain water,participatory decision maiking
Dispatchable concentrated Solar-to-X energy solution for high penetration of renewable energy (SOLARX)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Sustainable, secure and competitive energy supply
Action type: Research and Innovation actions
Countries involved: Spain,Netherlands,Denmark,Germany,France,Switzerland,Cyprus
Call: Next generation of renewable energy technologies (HORIZON-CL5-2021-D3-03, 2021)
Start date: 2022-11-01
End date: 2025-10-31
Duration (months): 36.0
Total project cost (EUR): 3036451.25
EU funding (EUR): 3036451.25
Participants: 13
Project status: SIGNED

Current energetic infrastructures are inefficient and hardly capable of integrating a large share of intermittent renewable energy sources. Carbon-neutral and high efficiency energy production adapted to local demands would be a breakthrough. SOLARX integrates 3 high concentration solar technologies and AI based smart resource management, to produce - either directly with high efficiencies or through storage stages for maximizing revenues - mainly electricity, heat for storage and/or SHIP and green H2 or Syngas in a carbon neutral way. Three Key Technological Elements will be developed: a smart solar resource management algorithm which aims to meet local instantaneous energy demands, a high efficiency CPV receiver and a carbon negative bi-energy H2 receiver. SOLARX’s main goal is to demonstrate the technical, economic and social relevance, at the laboratory scale, of the synergetic efficient production of heat, electricity and H2 from solar resource in a single facility, considering energy demands and market prices for a wide range of locations and application scenarios. SOLARX global assessment will demonstrate its role as a Game-changing RES within the framework of future implementation in a carbon-negative energy system. SOLARX will also provide power-to-X for larger integration of intermittent energy sources into the electric grid. The high efficiency concentration technologies allow to reduce the environmental impacts with respect to current technologies, as LCA study will demonstrate. Also, social acceptance and socioeconomic impacts will be assessed, on the base of, among others, previous high concentration experiences. The regulatory frameworks will be considered within the roadmap towards the technology commercialization and policy recommendations will be published. The share of SOLARX in the SHIP, electricity and renewable H2 global market by 2050 is expected to be 2-5%, 2-5% and 1-3%, respectively, while reducing by 1.5 GtCO2/year the emissions.

Keywords: green hydrogen,heliostat,solar concentration,cpv,renewable energy,energy collection,conversion and storage,ship
VARIFN: Understanding variation in the type I interferon response and its impact on infection susceptibility in humans. (VARIFN)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 1
Project status: SIGNED

Both antiviral immunity and susceptibility to viral infections are remarkably variable. Factors such as older age, increased body mass index, and male sex can increase the risk of developing severe viral disease, yet the impact of these features on antiviral immunity, particularly the type I interferon system (IFN-I), is not understood. Here we propose to use a systems immunology approach to identify features that influence IFN-I responses and understand their impact on infection susceptibility. We will use datasets and samples from the Milieu Interieur (MI) cohort of 1000 donors consisting 500 males and 500 females aged 20-69 years old. Using Simoa digital ELISAs, we have quantified IFN-I (IFNa and IFNb) in the supernatants of whole blood from the 1000 donors that was stimulated ex vivo with 7 agonists that activate the IFN-I system. Preliminary analysis of these results shows interesting age and sex differences in the IFN-I response. We will integrate the IFN-I cytokine data with existing demographic, microbiome, immune cell phenotyping and plasma protein data from the cohort and determine their associations with IFN-I levels. To investigate sex differences in IFN-I we will quantify sex hormones in the plasma of the 1000 donors. We will perform RNA-sequencing on IFNa-stimulated whole blood on a subset (n=200) of the donors to investigate the factors that shape the response to IFNa itself. We will perform genome wide association studies of the IFN-I response in the cohort to identify variants that influence IFN-I production using SNP genotyping data from MI. To determine the impact of these features on IFN-I and influenza infectivity in vitro, we will develop an organ on chip model encompassing features that we find to be associated with IFN-I levels in MI. Results from this project will identify novel regulators of IFN-I and shed light on new strategies to boost the antiviral response to better protect against viral infection.

Keywords: type i interferon,systems immunology,innate immunity,sex differences,inter individual variation
Firms’ Social Impact: Balancing Profits and Externalities (BALANCE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Italy
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1499420.0
EU funding (EUR): 1499420.0
Participants: 1
Project status: SIGNED

Firms conFirms contribute to society not only through profit-oriented activities such as innovation and job creation, but also by engaging in “altruistic” behavior by prioritizing broader social objectives, such as reducing pollution, improving labor conditions, and other pressing social issues. While economic theory suggests that externalities can be addressed through government interventions like taxes or property rights, incomplete information or political challenges often hamper these approaches. As a result, stakeholders must negotiate with firms, playing a key role in determining their social impact. Despite the importance of these negotiations, we know little about what drives them or how they influence a firm’s objectives. BALANCE breaks new ground both theoretically and empirically to assess how firms impact society and the underlying mechanisms. BALANCE’s overarching goal is achieved through four interrelated projects, each addressing distinct frictions that hinder stakeholders from demanding change. Project 1 examines prosocial banks, revealing how their entry affects borrowers’ productivity and long-term local economic growth. Project 2 examines how competition interacts with social impact—either differentiating a firm’s products or reducing its profit margins. Project 3 tackles information frictions in financial markets, where shareholders often lack awareness of whether others share their views on a firm’s green stance, potentially undermining coordinated efforts. Project 4 investigates information asymmetries in global value chains, where competitive pressures and opaque green certifications can lead to biodiversity loss. By integrating industrial organization and trade models with insights from finance and strategy, BALANCE pushes the research frontier while offering new policy tools. As public and private institutions tie financial support to sustainability, understanding how firms internalize their impacts on society is vital to fostering change.

Keywords: externalities,firm s social impact,theory of the firm,environmental economics,market structure,information frictions,structural estimation,ethical banking
Nonlinear analysis for virtual design of composite deployable space booms and membranes (NOVITAS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-03-15
End date: 2026-03-14
Duration (months): 36.0
Total project cost (EUR): 288859.2
EU funding (EUR): 288859.2
Participants: 2
Project status: SIGNED

NOVITAS aims to generate novel advances in the mathematical modelling of deployable and ultra-thin structures. They consist of booms and membranes that are first flat and coiled around a cylinder, and then they passively deploy, releasing the elastic strain energy stored during the furling phase. During history, deployable structures were adopted for various space applications, for instance, for telescopes, photovoltaic surfaces and antennas. The adoption of deployable booms allows larger structures to be easily and efficiently packaged for launch and reliably deployed on orbit. Despite the reliability of this kind of structure, there are still some issues to be tackled, including the development of a mathematical model able to deal with the accurate definition of the multiscale three-dimensional stress state and failure identification, the material viscoelastic effects, the effects of new composite materials and the multibody simulation for the deployment phase. We will address these issues with an innovative and interdisciplinary approach that combines theoretical, numerical and experimental investigations. The mathematical models formulated by NOVITAS will be able to accurately describe the nonlinear (mainly geometrical) behaviour that this kind of structure typically show during their services, whereas current models fall short due to their time-consuming analyses. We will compare and validate the numerical results with those obtained by experiments, which consists of the creation of a prototype at the Space Structures Laboratory at Caltech, for the viscoelastic and thermal multiphysics testing and simulation of deployment phases to be simulated with a multibody approach. The developed modelling technique will provide engineers with an efficient way for the design of space structures, consistently with the space-based technological innovation necessary for the always more ambitious needs of our society and to encourage a sustainable European economy.

Keywords: composites deployable structures nonlinear mechanics multibody analysis
Intensity Correlations for Stars (IC4Stars)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: France
Call: ERC ADVANCED GRANTS (ERC-2023-ADG, 2023)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 3499421.0
EU funding (EUR): 3499421.0
Participants: 1
Project status: SIGNED

The pioneering experiments of intensity correlations by Hanbury-Brown and Twiss more than 50 years ago not only allowed to measure the angular diameter of many bright stars, but it also motivated Roy Glauber to develop his quantum formalism of photon statistics. The advent of direct optical interferences of light collected by different telescopes developed in the beginning of the 70s, with superior performances in terms of signal to noise ratio and correspondingly reduced required observation time put an end to these first attempts of intensity correlation imaging for astrophysics. State of the art optical interference imaging is however limited by accessible baselines and the required mechanical precision for optical delay lines are limited in particular due to atmospheric fluctuations and at short wavelengths. In IC4Stars we will use modern photon counting techniques to perform quantum optics measurements and probe quantum systems in astrophysics. A first target will be a quantum degenerate Fermi gaz of electrons (a white dwarf) whose angular diameter is out of reach for direct optical imaging techniques. A second goal will be the search for quantum sources of radiation by looking for random lasing in astrophysics, to be detected by second order photon correlation.

Keywords: hanburry brown and twiss,intensity correlations,random lasing
Infrastructure for the EXtension of ODDs - applied in connected and aUtomated driving and Standardization procedures (iEXODDUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Safe, Resilient Transport and Smart Mobility services for passengers and goods
Action type: Innovation actions
Partnership: CCAM (co-programmed)
Countries involved: Austria,Spain,France,Germany,Türkiye,Switzerland
Call: Infrastructure-enabled solutions for improving the continuity or extension of Operational Design Domains (ODDs) (CCAM Partnership) (HORIZON-CL5-2023-D6-01, 2023)
Start date: 2024-12-01
End date: 2027-11-30
Duration (months): 36.0
Total project cost (EUR): 7358956.25
EU funding (EUR): 5991893.75
Participants: 14
Project status: SIGNED

The rapid advancement of autonomous vehicle technology promises enhanced efficiency and safety in transportation. However, operational constraints within Operational Design Domains (ODDs), including issues in sensing, behaviour prediction, and reliability, limit the potential of automated vehicles. Expanding the ODD framework is critical to enable these vehicles to navigate challenging scenarios like construction zones, unmarked roads, and adverse weather conditions. This expansion involves robust perception and decision-making algorithms, reducing the need for human intervention and facilitating integration with human-driven vehicles. While the benefits are substantial, challenges like data collection, sensor technology, and regulatory frameworks must be addressed through interdisciplinary collaboration. The iEXODDUS project is at the forefront of advancing digital technologies and navigation services, aligning with goals for increased safety, security, and sustainability in the mobility sector, ultimately paving the way for safer and more reliable automated transportation. iEXODDUS shall meticulously assess existing ODDs to unveil limitations and areas for improvement, fostering a deep understanding of ODD challenges and opportunities. This analysis serves as the foundation for a framework to assess and categorize ODDs across diverse automated driving scenarios. A key focus area is the enhancement of sensor technologies and perception capabilities through cutting-edge data fusion methods, expanding ODDs beyond current limits while considering environmental factors like weather conditions and road infrastructure. iEXODDUS envisions autonomous vehicles travelling across Europe, resolving harmonization and legal issues, and making policy recommendations. Collaboration with industry stakeholders and aiming for real-world demonstrations will enable an industry-tailored approach towards automated driving systems with extended ODDs.

Keywords: odd
Physics of the first mammalian epithelium (EpiPhys)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: France
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1999838.0
EU funding (EUR): 1999838.0
Participants: 1
Project status: SIGNED

Epithelia operate major biological functions throughout the human body. Forming de novo during preimplantation development, the trophectoderm (TE) is our first epithelium. The TE mediates the formation of the first mammalian lumen, which involves considerable physical challenges. Indeed, pressurized fluid, pumped through the TE, fractures intercellular contacts before cells squeeze this fluid into a single lumen. We recently found that cell adhesion and cell contractility determine the position of this lumen, which then controls further differentiation of the TE. This suggests that physical cues can determine the first mammalian axis of symmetry and TE patterning. However, most physical properties of epithelia controlling this process remain unknown, as their study in vivo has been so far very limited. In this project, we will investigate how the physics of the TE shapes and patterns the mouse preimplantation embryo, by using novel approaches, such as microfluidics and optical tweezers, that allow direct measurement of physical properties in vivo. First, we will determine epithelial transport properties of the TE and their regulation during lumen opening. We will next map plasma membrane reservoirs and membrane mechanics during preimplantation development. We will then characterize how the nuclear envelope and chromatin regulate nuclear mechanics during epithelial thinning. With this broad and unprecedented in vivo physical characterization, we will determine how epithelial transport, plasma membrane and nuclear mechanics influence epithelial stretching and patterning during lumen growth and positioning. Finally, we will determine the relative contributions of these physical properties in this process, and investigate their relationship. Together, we will build an integrated view of how uncharted physical properties of epithelia control stretching and patterning, in the context of a process that is key to the fertility of the ageing European population.