Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Innovative Laser Solution for Cutting Welding TWIP steel with IMProved Performance (TWIMP)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Action type: SME instrument
Countries involved: Italy
Call: Small business innovation research for Transport (H2020-SMEINST-2-2015, 2015)
Start date: 2015-11-01
End date: 2017-10-31
Duration (months): 24.0
Total project cost (EUR): 2704073.75
EU funding (EUR): 1892851.63
Participants: 1
Project status: CLOSED

Located in Scurzolengo, city with a high concentration of technology, robotics and automation companies,our Company, ELETTROSYSTEM SAS, is an expert for designing and building high technology solutions through assembly and testing process machines. Currently, ELETTROSYSTEM is one of the leaders in automation technology, with 17 products sold last year regarding special assembly machines, testing benches and complete process automatic lines production, where we obtained € 7.4 million turnover in the past year and we offer customized and dedicated solutions to our clients in most of the industrial fields, especially in automotive, aeronautical, energy and biomedical sectors. In addition, ELETTROSYSTEM has experienced an overall growth of 100 % in the last five years (from € 3.7 million to € 7.4 million turnover) thanks to the special relevance that our international expansion has starred, having presence in Germany, France, rest of Europe and North Africa, South America and Asia. TWIMP, is the stand-alone equipment for a complete cutting and welding process for TWIP steel. Our product does not only meet the finishing requirements but also will solve the other two current problems: -Cut and weld complex shapes (required for vehicle’s structural parts) by using a fiber laser head combined with a robotic arm and a CNC controller, which allows the possibility of moving the source to a precise position. -Reduce the total cost of the whole process by avoiding the use of filler material and making a final small and compact process machine (so power consumption will be reduced and no foundations would be required).

Keywords: welding,steel,automotive
Authentication and Authorisation For Research and Collaboration (AARC2)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: e-Infrastructures
Action type: Research and Innovation actions
Countries involved: Germany,Italy,Germany,Spain,Austria,Germany,Germany,Spain,Germany,Italy,Finland,Poland,Greece,Switzerland,Poland,Sweden,Czechia,Czechia,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: User-driven e-infrastructure innovation (H2020-EINFRA-2016-1, 2016)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 2999892.89
EU funding (EUR): 2999892.89
Participants: 29
Project status: CLOSED

The goal of AARC2 is to design an AAI framework to develop interoperable AAI, to enable researchers to access the whole research and infrastructure service portfolio with one login. AARC2's objectives are: 1. enable federated access in research communities participating in AARC2 2. assist research communities to map their requirements to concrete service offerings 3. support research (e-)infrastructures to implement the integrated architecture and policies frameworks developed by AARC project 4. offer different trainings to adopt AARC/AARC2 results 5. enhance the integrated architecture AARC2 objectives will be achieved by: - Piloting selected research community use-cases (SA1) - Showcasing ready-to-use AAI solutions and pilot results to infrastructures (SA1-NA2) - Developing a virtual Competence Centre where infrastructure representatives and AARC2 team discuss AARC2 results deployment and approaches to use-cases (all WPs) - Promoting federated access and adoption of AARC2 results via training and outreach (NA2) - Expand support for new technologies and policies (JRA1 and NA3). - Follow a user-driven approach: development driven by use-cases and continuous community feedback on AARC2 work. Relevance to the work programme: - AARC2 will work with existing e-infrastructures and ESFRI projects to deploy and enhance (JRA1) the integrated AAI (built on eduIGAIN and federated access) delivered by AARC (obj1–Development of a pan-European identity federation) - Use-cases that meet integration (accessing services offered by multiple e-infrastructures) and data-rich aspects included in AARC2 (SA1). AARC2 will work to enable federated access and to map the use-cases to existing AAI services and policy frameworks (obj2–Stimulate AAI services supporting communities in the data-rich era) - AARC2 will liaise with security groups, NRENs and infrastructures to address best practices in cybersecurity and assurance (see NA3). (obj3–Deliver an integrated infrastructure)

Keywords: authentication,authorisation,integrated aai,trust and identity
Plant-soil feedback and local adaptation along soil fertility gradients (PlantSoilGradients)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Estonia
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-09-01
End date: 2022-08-31
Duration (months): 24.0
Total project cost (EUR): 154193.28
EU funding (EUR): 154193.28
Participants: 1
Project status: CLOSED

In a process known as plant-soil feedback, plants can modify soil microbial communities in ways that differentially affect the performance of subsequent generations of plants. Recent studies suggest that plant-soil feedbacks may play an important role in plant community assembly and functioning, affecting plant species co-existence, primary productivity, succession and plant invasions. However, we still lack a basic understanding of how plant-soil feedbacks vary between different habitats and soil types. Moreover, plant-soil feedbacks may not only affect community and ecosystem-level processes but may also contribute to evolutionary dynamics within species and affect genetic diversity. The overarching aim of this project is to assess variation in the strength and direction of plant-soil feedbacks along soil fertility gradients in temperate grassland ecosystems at local through to large spatial scales. The proposal includes high-quality training and knowledge exchange between three countries. By combining concepts and experimental approaches from different disciplines, such as plant ecology, soil science, population biology and evolutionary and microbial ecology, we will build a mechanistic framework to predict plant-soil feedbacks in different environmental contexts and to assess their contribution to the maintenance of genetic diversity within grassland plant species. Collectively, improved knowledge of plant-soil feedbacks along soil gradients will enhance our capacity to identify those ecosystems most vulnerable to human impacts, such as invasions and land use change, and will enhance conservation and restoration of natural habitats. This proposal contributes to addressing one of the most pertinent societal challenges – maintenance of biodiversity in the face of global change – and includes a range of activities to engage with different audiences and stakeholders on the topic of soil biodiversity.

Keywords: plant soil interactions,grasslands,local adaptation
Wireless, Scalable and Implantable Optogenetics for Neurological Disorders Cure (WiseCure)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-09-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 224933.76
EU funding (EUR): 224933.76
Participants: 1
Project status: CLOSED

This WiseCure Fellowship aims to bring novel wireless, scalable, MRI-compatible, and bio-integrated neural implants for optogenetics to treat epilepsy. Neurological diseases such as epilepsy is a life-threatening progressive disorder causing uncontrolled activity of the brain (seizure). The ability to decipher brain functions and understand the neuronal communication networking properties to develop innovative solutions to treat neurological diseases remains one of the biggest challenges to date. A recent approach to study the brain is optogenetics. Optogenetics is a neural modulation technique which utilizes light to stimulate genetically engineered neurons, providing a better option for controlling the cells compared to conventional electrical stimulation. Scientists pursuing optogenetic therapies still face some technical challenges (e.g. size and multifunctional capability, biointegration, wireless capability, Magnetic Resonance Imaging (MRI) compatibility) that keeping optogenetics from clinical trials for brain diseases. I will combine the innovative wireless power transfer (WPT) approaches with ultrathin, soft and flexible biocompatible polymeric platforms to fabricate and characterize neural implants that are small enough to promote scalability, chronic reliability, and MRI compatibility. By associating the ability to wirelessly monitor (e.g. neural activities) and control (stimulation or inhibition) through these neural implants using a smartphone establishes a novel approach for versatile optogenetics to treat epilepsy. This Fellowship will act as a platform to realize my futuristic vision by integrating the wireless optogenetics system into smart healthcare using mobile and electronic technology for better diagnosis of the brain diseases, improved treatment of the patients, and enhanced quality of lives.

Keywords: metamaterials,biointegration,wireless neural interface
MECHANISMS BEHIND RESIDUAL DISEASE IN COLORECTAL CANCER and MODELLING OF THERAPIES THAT PREVENT RELAPSE (residualCRC)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: Spain
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Disease relapse is a major complication in colorectal cancer (CRC). At the time of diagnosis, the majority of patients will present with locoregional disease that can be effectively resected by surgery. This intervention is sufficient to cure the primary disease in most cases. Yet, over the course of the following months or years, around 40% of the patients that underwent resection of the primary tumor with curative intention will relapse, generally in the form of metastatic disease. As these metastases eventually interfere with the function of vital organs such as the liver and lungs, patients that undergo relapse have poor prognosis. Recurrent cancer arises from clinically occult tumor cells that have disseminated to foreign organs (disseminated tumor cells or DTCs) before surgical removal of the primary CRC. Although the time window between surgery and relapse offers a good opportunity to prevent metastasis, current therapies are not effective at eliminating DTCs. Thus, there is an important unmet need to develop strategies to target residual disease. Advances in this area will benefit a large proportion of patients. Despite its clinical relevance, the study of residual disease in CRC has been largely neglected and the principles that govern the behavior of DTCs remain unknown. The main reason for this important knowledge gap is that residual tumor cells are difficult to study in patients, as they remain clinically occult. We have recently generated a unique set of compound mutant mice and organoids that reproduce key features of human metastatic CRC. We propose to leverage these new models to study the biology of residual disease. We will characterize the features of DTCs using single cell transcriptional profiling, analyze the influence of driver mutations on DTC behavior, explore mechanisms of immune evasion during the latency phase, and model DTC latency in vivo and in vitro. Our ultimate goal is to design therapies that prevent disease relapse in CRC.

Keywords: colorectal cancer,metastasis,residual disease,disseminated tumor cells,tumor microenvironment,immune evasion,therapies,tumor organoids
Reconstructing habitat type and mobility patterns of Rangifer tarandus during the Late Pleistocene in Southwestern France: an ecomorphological study. (EmorphProject)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,Canada
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2021-03-31
Duration (months): 30.0
Total project cost (EUR): 210754.8
EU funding (EUR): 210754.8
Participants: 2
Project status: CLOSED

An animal´s habitat and mobility patterns hypothetically affect bone density and limb bone morphometry. The goals of this project are two: 1) test this ecomorphological hypothesis for a given taxon (Rangifer tarandus), and; 2) establish a reference sample for this taxon that will enable a reconstruction of its habitat type and degree of mobility using bone samples recovered from archaeological sites. This project quantifies the link between habitat type and mobility and bone density and morphology using X-rays and Computer Tomography (CT) and geometric morphometry (GMM). The study will focus on reindeer because it is a key prey species in many prehistoric contexts in both Europe and North America. Modern reference samples will be collected in North America, where Rangifer tarandus (caribou, aka reindeer) herds still exist in woodland (non-migratory) and tundra (migratory) habitats, making the creation of a referential framework possible. Once the relationship between habitat, mobility and bone structure has been quantified, the information collected will be applied to faunal assemblages from Upper Palaeolithic archaeological sites in Southwestern France and used to reconstruct prey mobility. Prey mobility is thought to influence the seasonal mobility of human predators and their hunting strategies. There is also a long-standing debate as to the migratory behaviour of reindeer in Western Europe during the Late Pleistocene and its influence on human systems. This project will develop an effective methodology to apply to archaeological faunas that will enable us to test whether human beings were hunting animals which migrated long or short distances, which will allow us to gain a better knowledge of their hunting strategies, the mobility of human systems and potentially their technological choices.

Keywords: rangifer tarandus,ecomorphology,statistics,migration patterns,prehistory,upper palaeolithic,magdalenian,southwestern france
Radiation risk appraisal for detrimental effects from medical exposure during management of patients with lymphoma or brain tumour (SINFONIA)

Framework: Horizon 2020 — Euratom
Programme: Nuclear fission and radiation protection
Theme: Radiation protection
Action type: Research and Innovation actions
Countries involved: Spain,Germany,Austria,Switzerland,Belgium,Greece,Poland,Sweden,Sweden,Belgium,Poland,Belgium
Call: Improving low-dose radiation risk appraisal in medicine (NFRP-2019-2020, 2019)
Start date: 2020-09-01
End date: 2024-08-31
Duration (months): 48.0
Total project cost (EUR): 5999998.75
EU funding (EUR): 5999997.5
Participants: 15
Project status: SIGNED

Reinforced risk appraisal of medical exposure is needed due to an extensive use of ionising radiation for diagnosis and therapy. The main objective of the 4-year SINFONIA project is to develop novel methodologies and tools that will provide a comprehensive a risk appraisal for detrimental effects of radiation exposure on patients, workers, carers and comforters, the public and the environment during the management of patients suspected or diagnosed with lymphoma and brain tumours. The scientific work will (1) develop novel AI-powered personalised dosimetry and risk appraisal methods and tools to estimate the radiation burden on patients undergoing state-of-the-art radiological, nuclear medicine and radiation therapy procedures, (2) reinforce risk appraisal for exposed staff, comforters, the public and the environment during nuclear medicine and proton therapy procedures, (3) determine the degree of patient variability in radiation sensitivity for the risk of developing secondary malignancies and (4) design and develop data management techniques for managing data from imaging and non-imaging examinations and radiation therapy sessions. A data repository will be developed for storing data as well as for the deployment of AI algorithms on an online platform. SINFONIA research outcomes for the two clinical examples, lymphoma and brain tumours, will be also applicable to other diseases. AI-powered personalised dosimetry tools will provide advanced knowledge on parameters affecting radiation detriment. This will help balancing risks and benefits of ionising radiation procedures and developing dose optimisation strategies. Additionally, radiation biology studies will identify individuals with increased susceptibility of developing cancer from ionising radiation exposure. SINFONIA also will organise high-level multidisciplinary training in the field of radiation dosimetry, risk appraisal and radiation protection and develop recommendations on radiological protection.

Keywords: low dose radiation risk appraisal,medicine,lymphoma,brain tumour
Nanoparticle Enhanced Hadron-therapy: a Comprehensive Mechanistic description (NanoEnHanCeMent)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Italy
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-11-01
End date: 2022-10-31
Duration (months): 24.0
Total project cost (EUR): 171473.28
EU funding (EUR): 171473.28
Participants: 1
Project status: CLOSED

NanoEnHanCeMent (Nanoparticle Enhanced Hadron-therapy: a comprehensive Mechanistic description) is an action aimed to apply basic Physics and Chemistry methods to uncover the microscopic mechanisms behind nanoparticle enhancement of hadron-therapy for cancer treatment (or ion beam cancer therapy). Hadron-therapy (radiotherapy using accelerated ion beams) is one of the most advanced radiotherapies available, with superior dose delivery and biological effectiveness as compared to conventional radiotherapy. The increased effectiveness of hadron-therapy relies on physico-chemical phenomena occurring on the nanoscale. There is experimental evidence pointing out to nanoparticles enhancing the biological effects of ion beams. Since nanoparticles can be tuned to target cancer cells, they might be used to further improve hadron-therapy. However, it is still unknown how nanoparticles produce this effect. A proper exploitation of the nanoparticle radioenhancement in hadron-therapy depends on improving the understanding of the physico-chemical mechanisms responsible for it. In this project, a theory and modelling approach is proposed, in which a series of semiempirical and ab initio methods will be extended and interfaced with Monte Carlo track-structure simulation tools, in order to advance the basic understanding of the nanoparticle enhanced hadron-therapy physical and chemical mechanisms. The action also encompasses an integral training program for the Experienced Researcher, with a deepening in already mastered methods and learning of new methodologies, together with the acquisition of complementary and transferable skills, all this in an environment where theory, experiment and clinical applications meet. A complete communication and outreach program is also envisaged, to disseminate the results to the scientific community and also to show to the citizenship how the investment in basic science and European cooperation pave the way for addressing societal challenges.

Keywords: nanoparticle radiosensitisation,particle radiation therapy,radiation biophysics,track structure,simulation,radiation physics and chemistry,biophysical modelling
TRANsport with QUantum nuclei in Ionic Liquids (TRANQUIL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Duration (months): 24.0
Total project cost (EUR): 203149.44
EU funding (EUR): 203149.44
Participants: 1
Project status: CLOSED

Transport coefficients govern the irreversible flow of extensive, conserved quantities, like mass, momentum, charge and energy. They are fundamental in both science and technology, governing from battery- and fuel-cell-efficiency to the lifecycle of planets. During the last decades, transport coefficients have been successfully extracted from equilibrium molecular dynamics (MD) simulations, according to the Green-Kubo theory of linear response. The theory has been also recently reformulated in ab-initio framework, thanks to the widespread use of density functional theory and new theoretical advancements, like the so-called gauge-invariance principle or novel data-analysis techniques. Despite these great advancements, when light nuclei are present, nuclear quantum effects can arise -like quantum tunnelling and zero-point energy effects-, which are not considered with standard molecular dynamics simulations with classical, point-like nuclei, and may strongly affect transport coefficients. In TRANQUIL we shall employ imaginary-time path integral molecular dynamics techniques to include NQEs in the transport properties of complex ionic liquids, relevant in energy-management technology and planetary science. Machine learning models will be exploited to construct ab-initio accurate force fields for faster MD simulations, as well as to define the atomic properties that are necessary to obtain well-defined microscopic fluxes needed in GK theory, like the dynamical charge or the local energy of each atom. TRANQUIL will also develop new, highly-scalable, and open-source software platform to manage the massively parallel MD simulations required, through the deployment of a targeted secondment. Within TRANQUIL, the experienced researcher will extend his scientific network of collaborations, and learn new leadership skills to boost his career as EU scientist in Condensed Matter theory and reach a full scientific independence.

Keywords: nuclear quantum effects,liquid insulators,path integral molecular dynamics,ring polymer,molecular dynamics,machine learning models,green kubo theory,statistical analysis of time series