Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
taRgeted thErapy for adVanced colorEctal canceR paTients (REVERT)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Italy,Italy,Germany,Italy,Germany,Germany,Romania,Sweden,Sweden,Luxembourg
Call: Systems approaches for the discovery of combinatorial therapies for complex disorders (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2023-12-31
Duration (months): 48.0
Total project cost (EUR): 5887273.75
EU funding (EUR): 5887273.75
Participants: 23
Project status: SIGNED

The REVERT project will address the specific challenge of understanding at system level the pathophysiology of mCRC cancer in patients responding well or poorly to therapies, in order to design optimal strategy for mCRC on a case by case basis, with therapeutic interventions modulated depending on patient’s features. Accordingly, REVERT will build up an innovative artificial intelligence (AI)-based decision support system using the experience and the real-world data of several general Hospitals operating in the EU healthcare system ultimately aimed at developing an improved and innovative model of combinatorial therapy - based on a personalised medicine approach - that identifies the most efficient and cost-effective therapeutic intervention for patients with unresectable mCRC. This goal will be pursued through the building of the REVERT-DataBase (RDB) thanks to a large number of standardized biobank samples with related structured data, and clinical databases (including known clinical and biological features as well as new, potential prognostic/predictive biomarkers) from several major clinical European centres. The RDB, in turn, will be used to build a sophisticated computational framework based on AI to evaluate its impact on survival and quality of life in a prospective clinical trial through testing of new treatment sequences of the available and authorised molecular targeted drugs in patients with mCRC. In the end, the REVERT will also generate an EU- network among SMEs, Research Institutions, Clinical Centres and Biobanks focused on R&D in the field of AI-Health for the development of personalised medicine. The REVERT software system will ensure the integrity of data and privacy management in respect to national rules, the EU's GDPR (Reg. EU 2016/679) and the EU Charter of Fundamental Rights. The RDB and AI services will be open to all partners during and after project’s completion, available also to EU research Institutions for future studies.

Keywords: unresectable colorectal cancer,new combinatorial therapy,database,computational framework,molecular mechanisms,predictive models,cancer progression,innovative ai based decision support system
gamma-MRI: the future of molecular imaging (GAMMA-MRI)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Spain,Switzerland,Belgium,Switzerland,France,Netherlands
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-04-01
End date: 2024-09-30
Duration (months): 42.0
Total project cost (EUR): 3372392.5
EU funding (EUR): 3372392.5
Participants: 8
Project status: SIGNED

Gamma-MRI will develop a clinical molecular imaging device based on the physical principle of anisotropic gamma emission from hyperpolarised metastable xenon. In the strategic move from “one size fits all” to personalised medicine, molecular imaging plays an essential role. However, despite significant technological advances in the last decades, medical imaging (especially for the brain) relies heavily on very expensive, complex and bulky machines. Moreover, MRI suffers from low sensitivity, only partially compensated by the recent advances in hyperpolarisation. On the other hand, the very sensitive PET and SPECT imaging modalities offer limited spatial resolution. Besides those trade-offs, the limited access to suitable devices still hinders the applicability of medical imaging to address major healthcare challenges in brain-related pathologies, even in Europe. Stroke alone is the second cause of death and the third cause of disability worldwide. The evolution of ischaemic damage varies much among patients. To achieve significant improvement in the outcome of the patients, a careful selection of the treatment path guided by images of the ischaemic brain, in a narrow time window of just a few hours is crucial. Unfortunately, point-of-care molecular imaging that could speed up patient management barely exists. Gamma-MRI is a game-changer imaging technology, combining the high sensitivity of gamma ray detection and the high resolution and flexibility of MRI, bringing down by multiple fold the cost of molecular imaging. Six closely interlinked work packages will cover: production of hyperpolarised gamma-emitting xenon isomers; preserving hyperpolarisation until delivery to targeted organ; developing advanced image acquisition and reconstruction using physics- and artificial intelligence- based approaches; designing and assembling the prototype upon a low field versatile magnet; and implementing the first preclinical Gamma-MRI brain imaging experiment.

Keywords: spect,hyperpolarisation,xenon,radiotracers,gamma detectors,low field mri,seop,polarised radioactive nuclei,stroke,brain,pre clinical imaging
Fiber Nano-Engineering (FINE)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Coordination and support actions
Countries involved: Germany
Call: FET Innovation Launchpad (H2020-FETOPEN-2018-2019-2020-4, 2020)
Start date: 2021-07-01
End date: 2022-12-31
Duration (months): 18.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Tunable optical-fiber-based micro-cavities offer a variety of applications such as for absorption microscopy, sensing, manipulation of solid-state systems, and quantum information processing. The key enabling technological element in these systems are optical fibers that feature a precisely shaped depression in the fiber end facet and are currently not commercially available. The FET-Open project SQUARE has taken initial steps towards the commercialization of fiber-based micro-resonators. During an initial supply of cavity fibers as standalone product, we recognized the high demand of this key technological element. The proposed FET project Fiber Nano Engineering (FINE) aims at identifying the relevant market segments by an in-depth market study and the development of an IP strategy to protect innovations in the manufacturing process. The arrival of additional inquiries about cavity fibers prompt us to advance the fiber manufacturing process to gain more throughput, less workload and more flexible products. The intended improvements include new strategies in the manufacturing process itself for increasing the quality and quantity of the production as well as software-based solutions to meet the specific inquiries. The supply with the final customized products will happen through a university spin-off, which is currently in formation.

Keywords: micro resonators
A Universal Micro-Server Ecosystem by Exceeding the Energy and Performance Scaling Boundaries (UniServer)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Ireland,Germany,Spain,Cyprus,Greece,Greece,United Kingdom,United Kingdom
Call: Customised and low power computing (H2020-ICT-2015, 2015)
Start date: 2016-02-01
End date: 2019-07-31
Duration (months): 42.0
Total project cost (EUR): 4815810.0
EU funding (EUR): 4815810.0
Participants: 10
Project status: CLOSED

The project’s principal aim is the development of UniServer: a universal system architecture and software ecosystem for servers. UniServer will facilitate the evolution of the Internet from an infrastructure where data is aggregated to centralized data-centres to an infrastructure where data are handled in a distributed and localized manner close to the data sources. UniServer will realize its bold goal by greatly improving the energy efficiency, performance, dependability and security of the current state-of-the-art micro-servers, while reinforcing the supported system software. UniServer will develop effective means to expose the intrinsic hardware heterogeneity caused by process variations, harness it and use it to its advantage for improving energy efficiency or performance. Lightweight, only software, mechanisms will be embedded for exposing to the system software the pessimistic voltage/frequency margins currently adopted in commercial processor and memory, which will be enhanced with new margin/fault-aware runtime and resource management policies. The UniServer technology will be ported on the world-first 64-bit ARM based Server-on-Chip and evaluated using smart emerging applications deployed in classical cloud business data-centres as well as in new environments closer to the data sources. UniServer aspires to deliver a unique fully working prototype that will turn the opportunities in the emerging Big Data and IoT markets into real, smarter products that can improve the everyday life and lead to a substantial financial and employment growth. The unique blend of expertise of UniServer’s consortium consisting of world leading low-power processor and Server-on-Chip suppliers (ARM, APM) as well as system software developer (IBM), and a set of emerging application drivers and established research organisations guarantees the successful realization of the ambitious goals, while reinforcing Europe’s strong position in traditional and new multi-billion euro market.

Keywords: micro servers,server on chip,energy efficiency,dependability,security,fog computing,cloud computing,internet sustainability
THE ROLE OF THE INFORMAL RECYCLING SECTOR ON CLOSING THE LOOPS TO SUSTAINABLE CITIES (IRS-CESC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-06-01
End date: 2020-07-07
Duration (months): 18.0
Total project cost (EUR): 146591.1
EU funding (EUR): 146591.1
Participants: 1
Project status: CLOSED

It is widely recognized that waste recycling can reduce both natural resource scarcity and negative environmental impacts of increasing trash production. Expanding the waste recycling is a key to construct Circular Economy (CE) approaches, contributing significantly to the global climate-change mitigation effort, at both local and national scales. Integrated Sustainable Waste Management (ISWM), of which waste recycling encompasses one part, is essential on a global scale. Innovative, low-cost methods of waste recycling was developed by vulnerable and marginalized waste pickers , which have led to the creation of an informal waste recycling sector (IRS) which are currently being used in Brazil and others LMIC, and have the potential to be more widely deployed. The IRS has developed work procedures that diverge from those deployed in EU recycling, setting a social technology (ST). This IRS ST is beneficial to ISWM, as it diminishes overall costs and amplifies quantities recovered, besides providing income to a poor, jobless population. This research will validate the possible gains from disseminating the Brazilian IRS ST to other LMIC countries as an ISWM policy and in support to CE strategies, which will involve a comparison of the Brazilian IRS with the EU recycling model; as such, it will consider how to make social and ecological value visible in value-analysis methods. The research will be carried on by the ER, whose ten years’ research has driven to a crossing point of economics, engineering, and environmental disciplines, the same scope of University of Leeds’ Cities theme. These will enable the ER to acquire the new skills and experience to achieve a position of an independent and professionally mature researcher in the field of CE at international level, leading interdisciplinary action-research groups to support international organizations on initiatives to more sustainable and inclusive cities, in direction to a Green Economy.

Keywords: waste recycling,informal recycling sector,resource recovery,inclusive waste management,sustainable cities
Quantification of volcanic halogen impacts in the troposphere through WRF-Chem modelling, satellite and in-situ observations (WCVolcano)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-01-03
End date: 2021-01-02
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

This project delivers a multi-faceted approach to understanding the halogen, ozone, and mercury chemistry of volcanic plumes in the troposphere. Small eruptions and continuous degassing volcanoes release halogens that are converted into reactive forms (e.g. BrO) in the plume and are known to have significant impacts such as the destruction of ozone and conversion of mercury into more toxic forms. However, at present, we lack the tools to quantify these impacts. By combining novel model and measurement approaches to this problem, this project will provide a very first quantification of the local-to-regional impacts on tropospheric ozone and mercury. To deliver this break-through the ER, Host and academic and industry partners each bring complementary expertise in high- and low-temperature plume models, multi-phase chemistry, satellite remote sensing, small sensors, and in-situ measurement of volcanic plume gases. The resulting ER’s training-by-research will place him at the centre of an EU collaborative activity on volcanic halogens. Central to this project is the ER’s development of a new atmospheric chemistry model of volcanic halogen impacts, WCV, with initialization based on high-temperature emissions. This tool will be an extension of the free and open-source community 3D model WRF-Chem and will be made available under the same terms. The ER will evaluate WCV through analyzing data from the newly-launched Sentinel 5-P satellite to trace volcanic BrO-SO2 at unprecedented resolution. Two field campaigns will make in-situ measurements of volcanic emissions and plume mercury, by industry mini-sensors and sampling methods. The combined WCV model-observation approach will make some very first case study assessments of volcanic halogen impacts on tropospheric ozone and mercury over local-to-regional scales. It will fill a critical gap in our understanding and quantification of volcanic plume hazards, bringing tools of strong interest to both research and policy groups.

Keywords: volcano,volcanic,halogen,modeling,satellite,troposphere,plume,bromine,chlorine,ozone,atmospheric chemistry,spectroscopy,mercury,aerosol,multi phase reactions
Microaggressions on College Campuses (MOCC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands,United States
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-12-01
End date: 2024-11-30
Duration (months): 36.0
Total project cost (EUR): 253052.16
EU funding (EUR): 253052.16
Participants: 2
Project status: CLOSED

Increases in cultural and linguistic diversity worldwide pose major challenges for universities to promote diversity, equity, and inclusion (DEI). Universities prioritize safety on campuses, but that process is severely hindered as many students of color face racial microaggressions daily, which impairs interethnic relationships and socio-academic adjustment. Thus although diversity is often expected to enhance inclusion and academic excellence of ethnic minorities, it is paradoxically linked to their exclusion and academic failure instead. This raises the question: How can universities create sustainable academic communities that promote DEI for all students? A promising method is living-learning communities (LLCs) which, unlike traditional residential housings, are specialized social settings centered on distinct academic themes that connect students’ experiences. LLC advocates argue that students develop a strong sense of belonging, learn how to think critically about social justice, and take multiple perspectives and develop a greater connection and better communication with other students. If this is true, do LLCs help prevent racial microaggressions among students who participate in such communities? And if so, how? That is, what are the key mechanisms? This study answers these questions through an innovative social network approach. Findings and mechanisms may be applicable to develop network interventions for integrated communities.

Keywords: microaggression,race,ethnicity,diversity,intergroup relations,higher education
Unraveling the ecology of a widespread fungal group by genomic, isotopic and physiological analyses (Mycena)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 208400.4
EU funding (EUR): 208400.4
Participants: 1
Project status: CLOSED

This proposal aims to shed light on the life strategy of Mycena (or bonnet mushrooms), a widespread group of macrofungi and with important functions in forests and other terrestrial ecosystems. While its members have traditionally been uniformly assumed to be degraders of litter, wood and other dead biological matter, very recent research has suggested that several members could in fact be parasitically or mutualistically biotrophic with plants. In numerous studies, environmental sequences with affinity to Mycena have been observed associated with plant roots. To solve this puzzle, we will use a multifaceted, interdisciplinary approach where we combine traditional knowledge about fungal cultivation with advanced DNA sequencing technology and isotope analyses techniques. The rapidly developing high throughput DNA sequencing technology (HTS) produces millions of DNA strands within hours, and by applying this to plant roots, we will quickly obtain an overview of the presence of Mycena in or on plant roots (indicating a possible biotrophic relationship). We will create a database of Mycena sequences from our own sequencing as well as sequences already publicly available. By sequencing the entire genome of five carefully selected species of Mycena, we will be able to analyse the genomic content associated with different life strategies. As molecular identification of Mycena associated with plant roots does not indicate an ecological interaction per se, we will employ innovative research techniques designed to quantify potential interactions. Isotopic fractionation of carbon/nitrogen of Mycenas and plants at field sites can reveal the mushroom´s source of carbon, and co-culturing of biotrophic Mycenas together with plants will provide direct evidence for the nature of their relationship(s). This research will clarify the ecology of a prominent and widespread genus of fungi, thereby illuminating its role in forest and general plant ecology.

Keywords: ecology,saprotroph,mycorrhiza,symbiosis,plant roots,nutritional mode,ecosystem function,high throughput sequencing,comparative genomics,bioinformatics
Illuminating Functional Networks and Keystone Species in the Gut (FunKeyGut)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: Austria
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2022-09-30
Duration (months): 66.0
Total project cost (EUR): 1498279.0
EU funding (EUR): 1498279.0
Participants: 1
Project status: CLOSED

We live in an intimate symbiosis with our gut microbiota, which provides us services such as vitamin production, breakdown of dietary compounds, and immune training. Sequencing-based approaches that have been applied to catalogue the gut microbiota have revealed intriguing discoveries associating the microbiome with diet and disease. The next outstanding challenge is to unravel the many activities and interactions that define gut microbiota function. The gut microbiota is a diverse community of cooperating and competing microbes. These interactions form a network that links organisms with each other and their environment. Interactions in such a “functional network” are based partially, though not exclusively, on food webs. Certain “keystone species”, such as Rumonicoccus bromii, are thought to play a major role in these networks. Though some evidence exists for the presence of keystone species, their identity and activity remains largely unknown. As keystone species are vital to networks they are ideal targets for manipulating the gut microbiota to improve metabolic health and protect against enteropathogen infection. Given the complexity of the gut microbiota, networks can only be elucidated directly in the native community. This project aims to identify functional networks and keystone species in the human gut using novel approaches that are uniquely and ideally suited for studying microbial activity in complex communities. Using state-of-the-art methods such as stable isotope labeling, Raman microspectroscopy, and secondary ion mass spectrometry (NanoSIMS) we will illuminate functional networks in situ. This will allow us to identify what factors shape gut microbiota activity, reveal important food webs, and ultimately use network knowledge to target the microbiota with prebiotic/probiotic treatments rationally designed to promote health.