Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Deciphering the mechanistic basis of minimal residual disease and treatment resistance in acute myeloid leukemia (MRDAML)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

Acute myeloid leukemia (AML) is one of the most aggressive and deadliest cancers with frequent relapse. Although initial therapies eliminate most AML blast cells, rare cells with leukemic stem cell (LSC) activity can persist and likely generate minimal residual disease (MRD) to re-initiate AML. Thus, targeting resistant LSCs during MRD might provide a unique opportunity to prolong remission and prevent relapse. However, because it is notoriously challenging to identify rare LSCs present within the vast number of normal blood cells during MRD, the phenotype, plasticity, function and mechanisms of LSCs in resistance and relapse remains poorly understood. Previous study from the Trumpp laboratory demonstrated a convergent pathway via hypermethylationn to drive initiation and progression of AML with IDH mutations or BCAT1 overexpression. However, the common and distinct mechanisms driving resistance in the two AML subtypes has not been explored, despite the observation that BCAT1 expression is upregulated in LSCs and upon relapse. Thus, in this proposal, I will first perform systematic phenotypic characterization of IDHmut/BCAT1hi AML cells to develop a high-quality LSC enrichment strategy. Subsequently, I will combine cutting edge single-cell multi-omics technologies to deeply characterize the mutational, transcriptomic and epigenetic dynamics of individual LSCs at diagnosis, MRD-positive remission and relapse. State of the art analytical methods will be used to integrate these data to dissect IDHmut/BCAT1hi AML with unprecedented resolution, examine the contribution of LSCs in MRD, and identify molecular regulators mediating LSC survival and resistance. Functional validation using pharmacological intervention, genomic editing in cell lines and patient-derived xenograft models will be performed to uncover causal relationships of the identified regulators. Overall, this work will lead to better mechanistic insight of MRD and therapy resistance in IDHmut/BCAT1hi AML.

Keywords: leukemic stem cells,acute myeloid leukemia,minimal residual disease,therapy resistance,relapse,single cell multi omics,transcriptomics,epigenetics,genome editing,resistance mechanisms
Ammonia and MOF Based Hydrogen storagE for euRope (AMBHER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Increased Autonomy in Key Strategic Value Chains for Resilient Industry
Action type: Research and Innovation actions
Countries involved: Spain,Netherlands,Italy,France,Belgium,United Kingdom,Germany
Call: Advanced materials for hydrogen storage (RIA) (HORIZON-CL4-2021-RESILIENCE-01, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 4915873.75
EU funding (EUR): 4915870.0
Participants: 18
Project status: SIGNED

AMBHER (Ammonia and MOF based Hydrogen for Europe) is a European project providing a holistic approach to tackle the short and long term energy storage challenges raised by the high degree of electrification our society is aiming for. Firstly, AMBHER is addressing the main societal, economic and technological questions coming together with the use of green ammonia as seasonal renewable energy storage. Simultaneously, AMBHER is developing and demonstrating innovative and cheaper compressed hydrogen storage potentially solving the gap toward local and economically relevant power-to-hydrogen hub. AMBHER will thus increase the number of applications in the energy and transport sectors and the possibilities for success and industrial adoption by key players. For short-term hydrogen storage, novel nanoporous MOFs (Metal Organic Frameworks) of high surface area (>2.500 m2/g) and low cost synthesis will be developed following an original shaping process (3D printing). Furthermore, AMBHER will develop a conformable cryo-vessel that can accommodate stacks of MOF bodies of tailored-made shape. A capacity of 40g/L of usable space at 100 bar is achieved at competitive cost with respect to current high pressure cylinders (600-1.000 euros/kg H2). For long-term storage, advanced materials (both catalysts and membranes) and their combination in an intensified 3D-printed intensified periodic open cell structured reactor will be developed to allow hydrogen storage in the form of ammonia (NH3) in a cost-efficient and resource-effective process at lower temperatures and pressures compared to conventional systems. AMBHER project is validating both short-term and long term solutions at TRL 5 addressing the positioning of the solutions developed in relevant business cases. The project is built around 16 industry and academic leaders in Europe, from 7 different countries. Track record of AMBHER partners proves the synergies and fruitful collaborative nature among all members.

Keywords: ammonia,mofs,hydrogen,storage,nanoporous,catalyst,membrane,membrane reactor
Operationalizing Climate Change Adaptation and Mitigation for aquaculture (OCCAM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Innovation actions
Countries involved: Norway,Belgium,Denmark,Faroe Islands,Germany,Iceland,Poland,Spain,Sweden,United Kingdom
Call: Minimising climate impact on aquaculture: mitigation and adaptation solutions for future climate regimes (HORIZON-CL6-2024-FARM2FORK-02, 2024)
Start date: 2025-05-01
End date: 2029-04-30
Duration (months): 48.0
Total project cost (EUR): 4935535.0
EU funding (EUR): 4500000.0
Participants: 22
Project status: SIGNED

The Operationalizing Climate Change Adaptation and Mitigation for aquaculture (OCCAM) consortium consists of 22 industry and research partners from across Europe. The OCCAM objective is to implement, test, and evaluate innovative solutions for climate change adaptation and mitigation in the aquaculture sector, and to deliver scalable, replicable, and exploitable solutions with accompanying recommendations ready for deployment in a wide variety of aquaculture supply chains. Some solutions are generic in nature with application across countries and sectors; this includes a Good Practice recommendation for self-assessment of CO2 emissions, guidelines for how to meet sustainability reporting requirements, templates for requesting and providing scientific advice, and a policy recommendation focusing on gaps and opportunities for climate-resilient aquaculture production. Other solutions are specific for sectors, species, and production methods, including solutions for carp, rainbow trout, salmon, bivalves, and seaweed (Ulva). To reduce emissions and contribute to aquaculture sector mitigation of climate change, sediments from freshwater aquaculture are upcycled, sludge is used to produce biochar, a digital tool for self-assessment of emissions from bivalve production is developed, and nets and pens with significantly reduced emissions are produced. Adaptation solutions include assessment of water availability and quality for freshwater aquaculture, selective breeding of more resilient rainbow trout, digital tools for forecasting and managing sea lice and Harmful Algal Blooms, and change of deployment parameters for oysters and seaweed given the expected changes in temperature and other environmental conditions. A prototype or proof of concept is developed for each solution, and where possible the proposed solution is also evaluated at a different site, and general recommendations are provided to other industry actors wishing to implement similar solutions.

Keywords: climate change,adaptation,mitigation
Investigation of host factors regulating virus proliferation in plant stem cells and germline (VirITAS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-09-01
End date: 2027-08-31
Duration (months): 24.0
Total project cost (EUR): 173847.36
EU funding (EUR): 173847.36
Participants: 1
Project status: SIGNED

With this proposal I will address a long-known but still not understood phenomenon in plant virology. Despite extreme replication rates in infected somatic tissues, many plant viruses are excluded from stem cells in the shoot apical meristem and subsequently from the progeny of flowering plants, suggesting that reproductive cells possess an exceptionally efficient antiviral defense. Yet some viruses overcome this barrier and pose a substantial agricultural risk of spreading viral diseases through seeds over great distances. Insight into the molecular basis of virus exclusion from stem cells and germline/progeny is therefore of utmost importance. Recent work by the host group leader indicates that RNA interference and plant defense hormones prevent viruses from entering the meristematic stem cells. If this exclusion is sufficient to prevent virus entry to the germline, which factors restrict seed transmission of different viruses, and at what stage of development they are relevant, will be addressed in this action by two independent unbiased screens. First, I will identify candidates regulating virus exclusion from plant germlines and vertical transmission by performing cell-specific transcriptomic analysis of gametes from healthy and infected plants aiming to identify enriched and depleted transcripts suggesting involvement of their products in antiviral defense. Second, I will compare viral seed transmission rates in natural accessions of Arabidopsis to perform a genome-wide association study and identify underlying genomic polymorphisms. The proposed work is expected to deliver ground-breaking insight into the mechanisms of transgenerational antiviral defense and novel mechanisms of antiviral immunity, with a high potential to contribute to disease control in plants.

Keywords: plant virus transgenerational antiviral barriers shoot apical meristem transcriptomics natural variation polymorphism arabidopsis thaliana
From Caterpillar to BUTTERFLY: supporting transformation of DCs in a paediatric oncology network (Maxima Butterfly)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Netherlands,United Kingdom,Germany,Italy,Switzerland,United States,France,Belgium,Austria,Spain,Australia,Slovakia,Czechia,Sweden
Call: MSCA COFUND 2021 (HORIZON-MSCA-2021-COFUND-01, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 3763200.0
EU funding (EUR): 3763200.0
Participants: 50
Project status: SIGNED

Every year, around 600 children in the Netherlands get cancer and one in four children dies from this illness. More than ten years ago, a group of parents and healthcare professionals in the Netherlands started working towards one national children’s cancer centre that could accelerate advances in treatment by centralizing all patient care and research in one building. Those efforts led to the creation of the Princess Máxima Centre for paediatric oncology: a unique centre that brings together all the highly complex care and research for children with cancer in the Netherlands. This concentration and integration of specialized paediatric oncology reflects our mission: ‘To provide a cure for every child with cancer while maintaining an optimal quality of life’. Only with innovative research we will be able to improve survival and quality of life for children with cancer. Our research covers the entire spectrum: from fundamental research to expose genetic and molecular characteristics of tumour cells to clinical trials to test improved treatment options. And from translational experiments to develop personalized therapy to psychosocial studies that monitor the wellbeing of the whole family. Collaborations within our center, between researchers and clinicians, but also partnerships with other institutes, nationally and internationally, are crucial to reach our goals. To contribute to this effort, the MAXIMA-BUTTERFLY programme will train the next generation of multi-disciplinary scientists in the field of paediatric oncology. For a successful implementation and to achieve a radical change in the society, the work needs to be translated to the academic community, the industry, health policy makers, regulatory authorities, insurance companies, doctors, patients, patients advocates, and the general public. Therefore, a multidisciplinary research team of scientists based in the Princess Máxima Centre are applying for a Marie Skłodowska-Curie COFUND grant for 28 DCs.

Keywords: paediatric oncology,preclinical and clinical research,personalised medicine,paediatric brain tumours and solid tumours,paediatric haematological malignancies,quality of life,cancer
Tracing knowledge graph provenance from textual knowledge sources (KG-PROVENANCE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Denmark,Netherlands
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 2
Project status: SIGNED

Knowledge Graphs (KGs) play a vital role in modern computer systems by organizing information efficiently through structured relations between concepts or entities. They provide a structured framework for storing and retrieving information, facilitating easier navigation and analysis of large volumes of data. This is crucial in interdisciplinary knowledge-intensive applications like disease diagnosis, drug discovery, ecological data interpretation, and specialized search engines. The knowledge in KGs is predominantly derived from unstructured textual sources, such as scientific articles and news feeds. However, verifying the origin of KG knowledge in these textual sources, known as the provenance of KG knowledge, is currently challenging. Provenance detection is essential for explaining and validating the knowledge stored in KGs and identifying potential inconsistencies with textual sources. To address the lack of efficient KG provenance detection models, my method will tackle two major scientific challenges. Firstly, dealing with a large volume of text as a source of information requires significant computational power, which poses a scalability problem. To overcome this, I will design subsampling methods to focus only on the most relevant textual passages that represent the knowledge in a KG. Secondly, the scalability problem is further complicated by the dynamic and evolving nature of knowledge, with millions of new textual sources appearing daily. This presents a challenge in efficiently identifying textual sources that contribute to knowledge shifts and using them as provenance to define KG updates. To address this, I will develop a novel scalable architecture to efficiently align knowledge shifts in text to concrete changes in KGs. Finally, I will closely collaborate with interdisciplinary industrial researchers to demonstrate the effectiveness of the developed methodology in real-world scenarios.

Keywords: knowledge graphs,information extraction,natural language processing
3D-printed Geopolymer using Waste-derived Alkaline Activators (3DGPWAA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: United Kingdom
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-08-01
End date: 2028-07-31
Duration (months): 24.0
Total project cost (EUR): 260347.92
EU funding (EUR): 260347.92
Participants: 1
Project status: SIGNED

In recent years, 3D printing has gained tremendous attention as the most popular additive manufacturing (AM) technology in the construction industry. The application of 3D printing could help increase revenue for construction companies while simultaneously enabling productivity through rapid automated construction. Moreover, 3D printing helps in reducing waste, labor, and environmental impacts that are associated with conventional construction methods. 3D printing of cement-based materials generates high carbon emissions which is a major challenge for the construction industry. In this regard, despite being relatively new, the 3D printed geopolymers (3DGP) hold relevance in the evolving landscape of low-carbon construction that eliminates the need for traditional cement. The main ingredients in geopolymers include precursor materials and alkaline activators. The precursor material comprises aluminosilicate wastes such as fly ash, slag, etc. while the activator is typically a combination of sodium hydroxide and sodium silicate solution. However, the high cost and environmental impacts associated with commercially available sodium silicate solutions limit the applications of 3DGP. Thus an affordable and environmentally friendly substitute for traditional activators is highly desirable. This research aims to develop innovative low-cost 3DGP mortar using alternative agricultural waste-derived alkaline activators. The proposal investigates the fresh and hardened properties such as setting time, workability, compressive strength, microstructure, and durability of the printed geopolymer mortar. Additionally, the sustainability of the printed geopolymer mortar will be assessed through the life cycle assessment (LCA) methodology. The use of waste-derived activators in making 3DGP will streamline the production process, offering a cost-effective construction technique that is essential to the future of Europe and the world leading to a greener future.

Keywords: sustainable construction,geopolymer,additive manufacturing,waste derived activators,rice husk ash,sustainability,circular economy
African Union Soil Observatory (AUSO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Innovation actions
Countries involved: Ghana,Netherlands,Nigeria,Uganda,United Kingdom,Italy,Lebanon,Senegal,Cameroon,Madagascar,Hungary,Switzerland,France,Central African Republic,Ethiopia,Kenya,Malawi,Zambia,Zimbabwe,Cabo Verde
Call: Assessment of Soil Health in Africa (HORIZON-MISS-2024-SOIL-01, 2024)
Start date: 2025-07-01
End date: 2030-06-30
Duration (months): 60.0
Total project cost (EUR): 7686631.38
EU funding (EUR): 7686631.38
Participants: 23
Project status: SIGNED

Africa's soils are in crisis, with widespread degradation threatening agricultural productivity, biodiversity, and water regulation. Unsustainable farming practices, climate change, and population growth exacerbate this issue, leading to reduced crop yields, food insecurity, and economic hardship for millions. Women and youth are particularly affected, facing increased workloads and limited educational and economic opportunities. Addressing these challenges requires accurate and accessible soil health data, which is often unavailable or hard to obtain across the continent. This hampers policymakers and researchers in monitoring soil conditions, tracking changes, and implementing targeted interventions. The AUSO project aims to tackle these issues by establishing a continental African Union Soil Observatory (AUSO), which includes an African Soil Data Center (ASDAC) and a Soil Health Dashboard to fill existing data gaps. Managed by FARA and owned by the African Union Commission, the AUSO will consolidate soil data from various national and international sources, creating a user-friendly platform for soil health monitoring. Through efforts to address data shortages and develop national soil health strategies in 12 countries, AUSO will empower stakeholders in the public and private sectors to make informed decisions, prioritize interventions, and support evidence-based soil and land management policies that promote sustainable agriculture. AUSO will build on the Soils4Africa SIS and draw insights from the EU Soil Observatory and other initiatives, ensuring relevance and adaptability to the African context. The project will adopt a co-development approach, engaging stakeholders from national agricultural institutes, government departments, and other key organizations.

Keywords: soil health,soil degradation,soil health policies and practices,soil health descriptors,sustainable land management
ViEWS – a political Violence Early Warning System (ViEWS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Norway
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-09-01
End date: 2024-02-29
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

This application presents a plan to explore the societal potential and financial viability of ViEWS – a political Violence Early Warning System, which has been developed as part of the ERC-AdG project no. 694640 at the Department of Peace and Conflict Research, Uppsala University, and Peace Research Institute Oslo (PRIO). It is a rigorous and transparent prediction system of unprecedented scope and performance that is positioned at the forefront of research on theoretical and methodological foundations for high-quality forecasts of political violence. The proposal describes how the research from the AdG project, as well as research conducted as extensions to the AdG project in collaboration with the UNHCR, UN ESCWA, and UK FCDO, can be applied to maximise the usefulness of the forecasting system for individuals and organisations that are dedicated to conflict prevention and mitigation, while simultaneously strengthening the system’s focus on transparency and open-access publication strategies. Planned activities include measures to solidify ViEWS’ reputation as a high-quality open-source early-warning system, and strategies to transform ViEWS into a financially viable and self-sustaining entity. The proposal also details concerted efforts to clarify our IPR position and strategy, incorporate recent user-specified developments into the early-warning system built under the AdG project, apply a user-centric approach to evaluate the predictive performance of the forecasting system (as a complement to current evaluation metrics), and a number of activities aimed at assessing, validating, and maximising the usefulness of the project's outcomes to the full target audience.