Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Pore-scale simulations to study the interaction of DIffusioPHORESis, flow and transport through porous media (DIPHORES)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-08-01
End date: 2022-07-31
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Flow containing suspended colloidal particles is found in a multitude of situations. Unexpected particle dynamics occur in the presence of local solute concentration gradients, due to cooperating and competing effects of particle migration driven by the solute gradients and advection. This particle migration, referred to as diffusiophoresis, is often accompanied by diffusioosmosis in which the solute gradients impose slip flows over solid surfaces. Recent investigations have shown that it is possible to achieve rapid particle focusing in micro-geometries by manipulating the properties of the solute, particle and flow, as well as the surface chemistry and configuration. This can be exploited for a plethora of applications. Most potential applications involve flow through porous media. Approaches for modelling flow through porous media at the Darcy scale are well established today, but their extension to introduce diffusiophoretic and diffusioosmotic net effects is not straight-forward, owing to their dependence on local effects at the pore scale. The combined study of diffusiophoresis and pore-scale flow dynamics has not been attempted to date. DIPHORES aims to carry out pore-scale simulations to study the interaction of diffusiophoresis and flow through porous media. The project activities include (a) development and implementation of a diffusiophoretic model a finite element code, (b) 2D and 3D pore-scale simulations and (c) upscaling of dynamics to the Darcy scale. The project will be conducted at Universidad Politécnica de Madrid (UPM), with an internationally leading expertise in pore-scale simulations. Secondment at Université de Lausanne (UNIL) is aimed towards defining test cases to be reproduced experimentally in micromodels. Secondment at Repsol S. A., an energy company, is aimed to assess the potential of the research topic towards a practical application.

Keywords: diffusiophoresis,porous media,pore scale simulations,navier stokes and advection diffusion equations,particle trapping,colloidal suspensions
Unravelling the mechanisms that allow endosymbionts to make themselves at home within hosts, from transfer to transit. (Host Sweet Home)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-10-01
End date: 2021-10-31
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

Endosymbiotic bacteria are usually not infectious, they have been thought to exclusively transfer vertically from the host mother to her offspring. Consequently we do often observe congruence between the phylogenetic trees of endosymbiotic bacteria and their host species, but not always. Evidences for the horizontal transfer of endosymbiotic bacteria between highly divergent host species have recently been accumulating, especially from studies in Insects. My own research on this topic led me to hypothesise that endosymbiotic strains not transferring horizontally may have lost the ability to do so and to establish into naïve hosts, contrasting to strains found in divergent host species. Instead of transferring, these strains would transit from a generalist state, able to jump and establish into naïve hosts, towards a more specialist state found in only few host species. Using Wolbachia bacteria-butterfly host associations and a multidisciplinary approach, I aim at (I) testing the evolutionary relevance of horizontal transfer of symbionts, (II) phenotypically characterizing generalist and specialist symbionts, and (III) identifying the molecular bases to the establisment of symbiosis. The novelty of this project lies into solving the dilemma associated to the endosymbiotic lifestyle: to maintain the mechanisms allowing transfer between hosts or to transit towards a specialised relationship with the host. ‘Host Sweet Home’ will to unravel the evolutionary history, and the constraints and outcomes of endosymbiosis. I will produce a large amount of genetic data, which analysis will result in highly significant research in the field of symbiosis, with a potential impact beyond the field of Evolutionary Ecology.
Neuroprotective human antibodies to the flexible tail of the prion protein (NeuroQure)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Switzerland
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2017-09-01
End date: 2019-02-28
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

The misfolding of the cellular prion protein (PrPC) causes infectious neurodegenerative conditions called prion diseases. In the framework of the ERC-funded study “The Prion Protein in Health and Disease” the team of Adriano Aguzzi has discovered that antibodies against the flexible tail (FT) of PrPC are neuroprotective against prion pathologies. Here we propose to clone and express such antibodies from humans and to develop them as antiprion therapeutics. The principal investigator has founded a company (www.Mabylon.com) which has established a high-yield method for cloning paired heavy and light chains from human memory B cells. The proposed research program will identify rare anti-FT immunoreactive individuals among large populations by high-throughput screening. The clinical information of the selected individuals will help to identify antibodies from persons devoid of pathologies that may be related to anti-PrPC autoimmunity. Therefore, the human antibodies generated within this program will represent fast-track investigational new drug (IND) candidates with safety profiles superior to those of murine or humanized antibodies. Completion of the proposed activities will lead to the development of therapies against prion diseases, which are currently considered untreatable and invariably fatal.

Keywords: protein aggregation,prion disease,neurotoxicity,immunotherapy
Nanostructured molecular decoders for the quantitative, multiplexed, layer-by-layer detection of disease-associated proteins (Immuno-NanoDecoder)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Research and innovation staff exchange
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Italy,Argentina,Italy,United States,United Kingdom
Call: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) (H2020-MSCA-RISE-2014, 2014)
Start date: 2015-04-01
End date: 2019-03-31
Duration (months): 48.0
Total project cost (EUR): 441000.0
EU funding (EUR): 441000.0
Participants: 5
Project status: CLOSED

The long-range goal of this project is to develop a molecular nanodevice, based on nucleic acid-protein conjugates, for the multiplexed, quantitative imaging of biomarkers in tissue samples and cultured cells. The Immuno-nanodecoder will be used for the accurate molecular characterization of skin cancer (melanoma) and glycogenosis type II cellular models and to evaluate the in vitro response to experimental therapies. The nanodevices (nanodecoders) will consist of self-assembled DNA nanostructures that can reversibly change their fluorescence signal output in response to hybridization to nucleic acid sequences, or to a specific enzymatic reaction. Each nanodevice will be coupled to a specific molecular probe, such as an antibody, peptide, or protein that uniquely recognize disease biomarkers. The coupling will allow the nanodecoder to detect biomarker presence and distribution in cells and tissues, in a layer-by-layer fashion, using optical fluorescence microscopy. The number of biomarkers that can be detected will be limited only by the capacity to design nanodecoders with differing specificities, which is essentially unlimited. The creation of nanodecoders and optimization of their function will greatly advance biomarker imaging, which currently lacks a high-throughput, convenient method for the in situ, quantitative microscopic analysis of altered tissue regions. This project will be driven by knowledge exchange and the expertise of an interdisciplinary team comprised of both early-stage and experienced university and hospital researchers. Complementary research programs, ranging from nanotechnology to molecular medicine and pathology will support each step of the developmental and applicative parts of the project towards the achievement of its objectives. Funding of this program will enable long-term, transformative collaborations that will contribute to the integration and collaboration of research groups between European Countries and key Third Countries.

Keywords: quantitative immunofluorescence imaging,multiplexed protein imaging,skin cancer,glycogenosis type ii rare disease,molecular nanotechnology,dna self assembly,biophysics
Establishment of services enhancing the innovation management capacity of SME's in the Enterprise Europe Network: IRELAND (Ireland-SME-Support)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Coordination and support actions
Countries involved: Ireland
Call: INNOSUP (H2020-Adhoc-2014-20, 2014)
Start date: 2014-07-01
End date: 2014-12-31
Duration (months): 6.0
Total project cost (EUR): 61250.0
EU funding (EUR): 49000.0
Participants: 1
Project status: CLOSED

Our proposal is aimed at providing specialised consulting services for building innovation management capacities in SMEs as well as supporting SME beneficiaries from H2020 funding through the KAM - Key Account Manager - role in overseeing specialist coaching services after assessment on innovation weaknesses.

Keywords: enterprise europe network ireland innovation support
Garibaldinism and radicalism: Traditions of transnational war volunteering in Southern Europe, 1861-1936 (Garibaldinism)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-09-01
End date: 2018-08-31
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

This project’s overall objective is to carry out a transnational study of the legacies and the survival of the myth of the so-called Garibaldinism between the experience of the the Italian unification (1861) and the Spanish Civil War (1936-39). Following both a social and cultural history perspective, it will analyse how the legacy of Giuseppe Garibaldi in Southern Europe was very strong and was linked with social and political claims. In our approach Garibaldinism will refer to a political and cultural phenomenon aimed at encouraging a board and consciously “popular” type of aggregation strictly linked to the tradition of armed voluntarism and the attempt to form an ideal homogeneous block that goes beyond the single ideological matrices and political formations of which it is composed. Between 19th and 20th Century several European generations, the last was the antifascist one, claimed for themselves the cultural, political, and ideal heritage of Garibaldinism. There were radical volunteers wearing the traditional red shirt in Poland (1863), at Crete (1866-67), in France (1870-71), in the Balkans (1876), in Greece (1897), in Serbia (1912 and 1914), in France again (1914) and in Spain (1936-39). A significant part of those volunteers were republicans, anarchists or socialists. There are three main questions addressed by this research project: • Is it possible to identify a long-term tradition of international armed volunteering linked with political radicalism between the 19th and the 20th Century? • Is it right to speak about a transnational Garibaldinism? • Is it possible to identify Garibaldinism as a bridge between different radical political creeds (e.g. Anarchism, Socialism and, later on, Communism)? The deliverables will be two papers published in leading journals and a book published in English. The fellowship will be highly beneficial to establish the PI as one of the leading European experts on International armed volunteers in European history.

Keywords: transnational war volunteering,transnational history,social history,political radicalism,southern europe,19th century,20th century,garibaldi,transnational networks
Controller Tools and Team Organisation for the Provision of Separation in Air Traffic Management (PJ10 PROSA)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Austria,Spain,Ireland,Italy,Italy,Australia,Germany,Germany,Italy,Italy,Germany,Malta,Poland,Poland,Switzerland,Serbia,Belgium,Bulgaria,Croatia,Hungary,Lithuania,Slovakia,Sweden,Norway,Belgium,France,France,France,Czechia,Czechia,Netherlands,Denmark,United Kingdom,Denmark
Call: Separation Management En-Route and TMA (H2020-SESAR-2015-2, 2015)
Start date: 2016-11-01
End date: 2019-12-31
Duration (months): 38.0
Total project cost (EUR): 43248874.13
EU funding (EUR): 26388518.93
Participants: 54
Project status: CLOSED

Single European Sky – the vision is clearly described in the ATM Masterplan. Reaching the goals for the European Airspace is only possible with focused technical developments on European level. The air traffic controller is the main player in the traffic management at tactical level. This project aims at providing the air traffic controller with more automated tools, thus freeing capacity for situations where human intervention is crucial. This provides even safer service for an increasing amount of traffic and with lower costs, as required by airspace users. This project is a part of the SESAR programme and addresses separation management. It will not only improve current conflict detection tools, but also develop new tools aiding the air traffic controller with resolution advisory and monitoring of flight trajectory. The project also addresses new ways of working together. Air traffic controllers traditionally work in pairs and in specific airspace. Could we change this to multi-planner setup, sector less airspace and seamless cross-border operations? Our project will ensure the research is developed to a stage where it can be used in operational air traffic management systems in Europe. This ensures that anyone can fly safer, cheaper and quicker in Europe in 10 years. Another really important issue is the integration of “Remotely Piloted Aircraft Systems” – drones. Drones are new to European Air Traffic Management, and it is urgent to address concepts and technological developments needed to handle this kind of traffic safely. The companies involved in this project are the only ones that can deliver this kind of result. Not on their own – but as the unique cooperation between air navigation service providers and air and ground industry. The capabilities to provide sustainable results usable throughout Europe by fast-time, real-time simulations and live trials ensures that developed prototypes are working in the context of future traffic and ATM systems.

Keywords: controller support tools,team organisation,separation management,rpas,automation in atm,controller license,validation,simulation,multi sector planner,flight centric atc,collaborative control
Closure of the Cloud Phase (C2Phase)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth system science
Panel description: Physical geography, geology, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Germany
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-04-01
End date: 2023-09-30
Duration (months): 78.0
Total project cost (EUR): 1499548.75
EU funding (EUR): 1499548.75
Participants: 1
Project status: SIGNED

Whether and where clouds consist of liquid water, ice or both (i.e. their thermodynamic phase distribution), has major impacts on the clouds’ dynamical development, their radiative properties, their efficiency to form precipitation, and their impacts on the atmospheric environment. Cloud ice formation in the temperature range between 0 and -37°C is initiated by aerosol particles acting as heterogeneous ice nuclei and propagates through the cloud via a multitude of microphysical processes. Enormous progress has been made in recent years concerning the understanding and model parameterization of primary ice formation. In addition, high-resolution atmospheric models with complex cloud microphysics schemes can now be employed for realistic case studies of clouds. Finally, new retrieval schemes for the cloud (top) phase have recently been developed for various satellites, including passive polar orbiting and geostationary sensors, which provide a good spatial and temporal coverage and a long data record. We propose here to merge the bottom-up, forward modeling approach for the cloud phase distribution with the top-down view of satellites. C2Phase will conduct systematic closure studies for variables related to the cloud phase distribution such as the cloud ice area fraction, its distribution as function of temperature and its temporal evolution, with a focus on Europe. For this, we will (1) use clustering techniques to separate different cloud regimes in model and satellite data, (2) explore the parameters and processes which the simulated phase distribution is most sensitive to, (3) investigate whether closure is reached between state-of-the art cloud resolving models and satellite observations, and how this closure can be improved by consistent and physically justified changes in microphysical parameterizations, and (4) use our results to improve the representation of mixed-phase clouds in weather and climate models and to quantify the impacts of these improvements.
Leggett-Garg test of a vibrating carbon nanotube (LeGaNa)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-03-01
End date: 2018-02-28
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Despite the undeniable success of quantum mechanics, the boundary between quantum and classical mechanics remains unclear. Leggett and Garg devised a class of inequalities that provide the script for a quantitative test to determine whether a macroscopic object would indeed be at all times in one of its distinct states or whether quantum mechanics would prevail. I will perform the first Leggett-Garg test on a massive moving object: a carbon nanotube resonator. This ambitious experiment would be a key accomplishment in mapping the persistence of quantum features in systems of increasing macroscopicity.

Keywords: qubit,nanotubes,quantum foundations,nanomechanics
Pulsed plasma technology for 2D materials integration (PULSE2D)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-09-01
End date: 2019-08-31
Duration (months): 24.0
Total project cost (EUR): 160800.0
EU funding (EUR): 160800.0
Participants: 1
Project status: CLOSED

Atomically thin layers of transition metal dichalcogenides (TMD) are gaining increasing attention as new materials for future Beyond-CMOS electronics. Recently, a great progress has been made in deposition of high quality layers of TMDs paving the way towards wafer scale device manufacturing. However, many fundamental and technological challenges still have to be addressed. Precise tuning of the number of layers, doping, surface functionalization and selective low damage etching of TMDs are among the most critical technological steps. Plasma processing is an enabling technology used for doping, etching and deposition of ultrathin layers in microelectronics industry. However, the application of plasmas for integration of 2D materials remains marginal and poorly controlled. The major challenge for plasma treatment of atomically thin materials is the need for unprecedented control of fluxes and energies of plasma species at the substrate. Pulsed plasma technology holds promise of reaching conditions required for low damage processing of 2D materials with a single atomic layer precision. The ambition of PULSE2D is to develop highly controlled pulsed-plasma technology for integration of TMDs in nano-electronic devices on a wafer-scale. A fundamental study of the mechanisms of interaction between pulsed plasmas and atomically thin TMD materials will be performed. Defect production, adsorption and etching processes will be quantified as a function of plasma parameters. This information will be used to perform atomic layer etching, functionalization and defect healing of TMDs using pulsed plasmas. The research and training activities will enhance technical skills of the candidate in the emerging area of plasma processing of 2D materials, industry-relevant nano-fabrication and measurement of TMDs transport characteristics. High fundamental and technological interest and timeliness of this subject will provide a powerful thrust for the future research career of the candidate.

Keywords: transition metal dichalcogenides,2d materials,pulsed plasma treatment,doping,atomic layer,etching,defect healing,ion energy control,high k dielectric gates,atomic layer deposition