Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Design of Novel Polyelectrolyte Multilayer Based Delivery Systems for Therapeutic Antibodies and siRNA (DESIRNA)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Industry-Academia Partnerships and Pathways
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain,Germany,Germany
Call:  (FP7-PEOPLE-2009-IAPP, 2009)
Start date: 2010-06-01
End date: 2014-05-31
Duration (months): 48.0
Total project cost (EUR): 672519.0
EU funding (EUR): 672519.0
Participants: 3
Project status: CLOSED

The design and fabrication of biocompatible carrier systems for RNA based medicine and therapeutic antibodies equipped with multiple functions suitable for controlled and targeted delivery is the main scope of this proposal. General strategies for the encapsulation and release of RNA and proteins will be developed on the basis of the Layer by Layer technique (LBL) employing core materials tailored to the physico-chemical properties of the respective medications. Alternatively, RNA and antibodies can be also assembled between polyelectrolyte layers. The multilayers will progressive degrade in extracellular media or after being uptake in cells. The progressive degradation of the multilayer will provide a sustainable delivery of the therapeutic agent. The LBL provides also the means to modify the surface of the carrier to increase circulation or to increase specific uptake, according to the intended therapeutic action. To fulfil this aim biocompatible lipid layers will be engineered onto the surface of the carriers. This lipid coat is furthermore the matrix for the incorporation of targeting functions. The encapsulation of therapeutic antibodies, besides its very general importance, specifically addresses ocular applications, to meet urgent delivery problems. The design of a RNA carriers intended for silencing specific genes addresses a rather challenging problem of delivery. Its solution may help to pave the way for the application of the powerful RNA tools as therapeutic agents. The processing and distribution, in vitro and in vivo, of these carriers will be intensively studied. A comprehensive knowledge of how these processes take place will be paramount for the improvement of the coatings and to enhance their performance. Cyitotoxicity of carriers will also be studied.

Keywords: pharmaceutical chemistry,coloids and surfaces,nanochemestry,drug delivery,self assembly,rna delivery. bio and non-bio interactions
Environmental heterogeneity and AMF genetic diversity (AMFGENDIV)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2010-08-01
End date: 2013-07-31
Duration (months): 36.0
Total project cost (EUR): 243304.0
EU funding (EUR): 243304.0
Participants: 1
Project status: CLOSED

Arbuscular mycorrhizal fungi (AMF) form mutualistic symbiosis with roots of the majority of terrestrial plants. They are ceonocytic, known to harbour genetically different nuclei. However, the dynamic and maintenance of this genetic diversity are unknown. We have recently found two important processes that are likely to play a role in AMF: a) single spores do not necessarily inherit the same genetic material due to unequal segregation of nuclei during spore formation; b) mixing of nuclei between different individuals can occurs through genetic exchange. Under which circumstances these mechanisms could play a role in the maintenance of genetic diversity has been poorly studied and their occurrence in other AMF populations and species is unknown. Recent investigations suggest that environmental heterogeneity could be a process for the maintenance of genetic diversity and needs further investigations. Additionally, studying how plants respond to the dynamic of AMF genetic structure could allow us to understand how plant and fungi co-evolve. Finally, an important point would be to know whether local adaptation, segregation and genetic exchange could explain the genetic structure of AMF populations in the field. The three objectives of the proposed project will be to 1) test the effect of environmental heterogeneity on AMF genetic structure; 2) determine whether segregation and genetic exchange occur in other AMF populations and species; 3) compare our results with field data. It appears clear that understanding the dynamic and the maintenance of genetic diversity of AMF is essential for understanding the ecological importance of this very common symbiosis, for its application in agriculture and environmental management, and for understanding how organisms evolve and coevolve over long periods of time in a mutualistic environment.

Keywords: mutualistic symbiosis,amf,genetic diversity,segregation,genetic exchange,environmental heterogeneity,coevolution
Long Term Research on Sea Turtle Ecology and Conservation (RESET-ECO)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Spain
Call:  (FP7-PEOPLE-2009-RG, 2009)
Start date: 2010-04-01
End date: 2013-03-31
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

Long term monitoring and conservation management are mandated for adequate estimations of sea turtle population size, conservation status and trends. In this multidisciplinary project, a former Marie Curie postdoctoral scientist experienced in reproductive ecology of marine turtles will fuse his expertise, enhanced during his postdoctoral fellowship, with an integrated approach using state-of-the-art technological tools. The applicant will perform electronic nest monitoring, satellite tracking, molecular genetics analyses and remotely sensed oceanography to study the ecology and conservation status of marine turtles nesting populations in the Dominican Republic (DR), as a continuation of his research in the past two years. The true quality of this bid lies on two aspects: First, in its broad-reaching and integrated approach to the study of these populations of critically endangered migratory marine vertebrates; and second, in the transfer of knowledge and use of novel techniques learnt by the applicant from the team and the country where he was placed for his fellowship, to the new host institution. The scientific literature, conservationists, local and regional stakeholders in Dominican Republic, the new host institution and the applicant will all benefit immensely.

Keywords: marine biodiversity,animal ecology,sea turtles,conservation,global climate change,migration
Christianity in China. Western Culture in front of the Far East. Adaptionism, Syncretism and Simulation. The specific case of a small and important group of French Jesuits: the Figurists. (CHINACQR)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-05-01
End date: 2012-04-30
Duration (months): 24.0
Total project cost (EUR): 215030.4
EU funding (EUR): 215030.4
Participants: 1
Project status: CLOSED

The Society of Jesus was the link between Europe and the Far East. This was possible thanks to the elaboration of an entirely new model of evangelization based on the assumption that cultural differences were to be “ironed out” in favor of similarities that allowed the Jesuits to enter, like a Trojan horse, the alien culture: this model was called accommodatio. The second step of this strategy was the extraordinary production of books and pamphlets written by Jesuits in the centuries of their missionary activity in the Far East. Chronicles, travel accounts, and polemical treatises accompanied the Jesuits’ mission, and found a Western audience among Enlightenment thinkers, to the point that the “discovery” of China became a fundamental point of reference of Western culture. This is the traditional account but it is necessary and possible now to verify it by using a new approach. First, it is necessary to read again the documents regarding the first penetration of Christianity in China, in the prospective of sixteenth-century European culture: literary culture of simulation or honest dissimulation in the European courts, nicodemism in religious thinking, and in the specific contest of Society of Jesus (in Europe and outside); from Matteo Ricci onwards, specially the writings of first Jesuits in China, and the regulations and discussions inside the Society. Finally, we need to look at them through the Figurists, when nicodemism or similar is replaced by a new way of cultural interpretation that really joins together the Western and Far East worlds. A bibliographical investigation of the Figurists’ writings (often not printed), their contact with European philosophes and the role they had in the Enlightenment’s evolution of concepts of China will complete the study.

Keywords: humanities history modern history religious sciences church studies non-christian religions,intellectual and cultural history,enlightenment,comparaison,idea of europe,idea of china
Development of molecules for the stabilization of quadruplex DNA and regulation of oncogene expression: a potential route to novel anticancer drugs (DMSQD)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-01-01
End date: 2012-12-31
Duration (months): 24.0
Total project cost (EUR): 172240.8
EU funding (EUR): 172240.8
Participants: 1
Project status: CLOSED

In this project we aim to develop a series of metal-containing molecules with the ability to interact with specific DNA sequences. More specifically, we will target what is called quadruplex DNA. It has been recently identified that there are approximately 350,000 sequences in the human genome that can potentially form quadruplex DNA structures. More interestingly, some of these regions have already been identified as potential targets for the development of cancer drugs. Therefore, we will aim to develop metal complexes that can selectively interact with these specific quadruplex DNA structures. The project will involve the design (aided by computational methods), development and characterisation of the new molecules. The DNA binding properties of these molecules will be evaluated using a range of techniques (e.g. FRET, FID, SPR and CD). This will allow us to identify lead molecules (those that interact more strongly and selectively with specific quadruplex DNA structures) so that their biological activity can be evaluated.

Keywords: chemistry,inorganic chemistry
Emission analysis. Tools required to perform the emission analysis and evaluation methodology (EMICOPTER)

Framework: FP7 — Cooperation
Programme: Joint Technology Initiatives (Annex IV-SP1)
Theme: Public-private partnerships
Destination: Clean Sky
Action type: Article 171 of the Treaty
Partnership: CLEAN-SKY (Art-185)
Countries involved: Italy
Call:  (SP1-JTI-CS-2009-01, 2009)
Start date: 2009-12-01
End date: 2012-11-30
Duration (months): 36.0
Total project cost (EUR): 399391.0
EU funding (EUR): 299543.0
Participants: 1
Project status: CLOSED

The project aims to define an effective procedure to determine pollutant emission from helicopter engines during different flying conditions. The basis strategy is to couple detailed kinetics, needed to determine those components which are present in a low or very low concentration, with detailed fluidynamics necessary to describe in an accurate way the thermal and fluid flow fields, which control the pollutant formation/reduction. After an accurate analysis of the state of the art, starting point of the activity is the definition of the helicopter surrogate fuel and the development, tuning and validation of their combustion kinetics. The resulting detailed mechanism is the starting point for the construction of an optimized global few step kinetic mechanism to be used in CFD computations. The CFD simulations are based on the global mechanism, the combustor geometry and flying conditions. The temperature and flow field coming from CFD and the detailed kinetic scheme are the input for the postprocessing activity for the pollutant emission estimation. Effective and parallel numerical algorithms increase the performances of such a time consuming activity. Several CFD and postprocessing computations in the different flying allow to compare with experimental results. In this procedure some iterations could be necessary. The fluidynamic results can show the need of detailed and/or global kinetic refinements. As a consequence, the output of CFD computations can impact on detailed kinetic scheme development and validation and/or to the global few step mechanism. Again, over- or under-estimations of the emissions from postprocessor could require to revise either the kinetics or the CFD.

Keywords: emissions. nox. co. unburned hydrocarbons. co2. gasturbines. detailed kinetics. global mechanisms. cfd
Novel Experimental and Modelling approach for Optimisation of Light alloys (NEMOLIGHT)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Outgoing Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-IOF, 2009)
Start date: 2010-08-11
End date: 2012-08-10
Duration (months): 24.0
Total project cost (EUR): 138821.8
EU funding (EUR): 138821.8
Participants: 1
Project status: CLOSED

We propose a novel multi-disciplinary approach for the optimisation of light alloys for structural applications in the objective of weight savings and reduction of greenhouse gas emissions for transportation applications. This approach will combine advanced experimental investigations in the fields of physical metallurgy and materials electrochemistry and the development of a mesoscopic modelling tool, and will be applied to precipitation-hardening Aluminium alloys. The development of nano-scale, multi-phase precipitate microstructures will be quantitatively characterised by advanced experimental techniques, including time-resolved synchrotron X-ray scattering, nuclear magnetic resonance, atom probe tomography and electron microscopy. It will be modelled by a physically-based approach, going well beyond the state-of-the-art by addressing the complexity of the sequence of metastable phases and of the competitive formation of multiple phases in multi-constituent alloys. The project will be carried out first on a model Al-Cu-Sn alloy and then applied on industrial alloys. The project will be carried out in two institutions that are world leading in their respective fields of physical metallurgy and design of light alloys. It will involve active training of the main researcher on multi-disciplinary experimental research tools, on modelling of phase transformations in metals, and on research administration. The project will improve the excellence of the return host (Grenoble Institute of Technology) in the field of light alloy research, improve its international links and recognition, and will impact Europe’s capabilities in the design and production of high performance light alloys. The project will improve the prospects of the main researcher to reach a prominent academic position in his field of research and teaching.

Keywords: materials engineering,light alloys,aluminium,precipitation strengthening,alloy optimisation
The use of potentially protective bacteria in aquaculture against fish pathogenic Flavobacterium spp. (AQUABAC)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: United Kingdom
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2010-05-01
End date: 2012-04-30
Duration (months): 24.0
Total project cost (EUR): 173240.8
EU funding (EUR): 173240.8
Participants: 1
Project status: CLOSED

Flavobacterium psychrophilum and F. columnare cause high mortalities in salmonid culture as the cause of various surface and systemic infections. Traditionally, Flavobacterium infections have been treated with antibiotics, but this is an emotive issue because of the perceived problems associated with tissue residues and the development and spread of antibiotic-resistant bacteria. Indeed the high susceptibility of Flavobacterium for the antibiotics commonly used in EU fish farms has been recorded. Alternative methods of disease control are needed for which the use of bacteria as probiotics and/or water treatments is gaining attention. Thus, the role of the beneficial bacteria is to exclude pathogens and promote the good indigenous microbial flora in fish. The aim of this research is to optimize protective bacteria which work as biological control agents against Flavobacterium infections. The research will focus on three bacterial cultures which have been highlighted in preliminary in vitro and in vivo work by the researcher, to determine their mode of action for disease control in salmonid culture. As Flavobacterium usually affects the host through external surfaces, it is proposed to study how the beneficial bacteria exclude the pathogen from these surfaces. Furthermore, the role of bacterial subcellular components will be investigated by means of immunoproteomics. Although immunoproteomics is extensively used in vaccine production, their use here would lead to more precise information about the nature of similar or shared antigens between the protective bacteria and pathogenic Flavobacterium. Apart from enabling research on a topic of relevance to European aquaculture, this Fellowship would be greatly advantageous to the researcher’s career development, by the provision of training and a personalized research programme with high quality outputs in the laboratories of well known and respected academics in the Institute of Aquaculture at the University of Stirling.

Keywords: aquaculture,probiotics,potentially protective bacteria,fish diseases,flavobacterium,immunology,rainbow trout
The Development of a Novel Tin-Free Radical Methodology and its Application to the Asymmetric Total Synthesis of (+)-Ineleganolide. (RADICALS 2009)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Incoming Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-IIF, 2009)
Start date: 2011-01-01
End date: 2012-12-31
Duration (months): 24.0
Total project cost (EUR): 166645.6
EU funding (EUR): 166645.6
Participants: 1
Project status: CLOSED

Preliminary work in the Zard&amp;apos;s group has shown that cyclopropylacyl radicals can be generated from the corresponding xanthates. These unique species do not easily undergo decarbonylation or ring opening processes. These features can be exploited because the products, cyclopropyl ketones, have been found to be exceptional substrates in organic synthesis. Additionally, control of the decarbonylation and/or ring-opening processes can be combined with the powerful nature of the xanthate transfer technology in a synergistic way to provide complex skeletal diversity. The first part of the project will not only exploit the observed reactivity pattern for cyclopropylacyl radicals but will expand significantly their chemical reactivity and scope. The second part of the project will apply these findings to the asymmetric total synthesis of the natural product (+)-Ineleganolide.

Keywords: radicals,total synthesis,organic chemistry,xanthate,synthetic methodology
Determination of the Fate of Inorganic Components upon Gasification of Sewage Sludge (INORGASS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Intra-European Fellowships
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-2009-IEF, 2009)
Start date: 2011-10-01
End date: 2013-09-30
Duration (months): 24.0
Total project cost (EUR): 229747.2
EU funding (EUR): 229747.2
Participants: 1
Project status: CLOSED

Gasification is a promising technology for the production of renewable energy resources from biomass and waste streams, offering the advantage of providing a safe disposal route for organic pollutants. However, a major concern is the unclear fate of inorganic components during gasification, which brings about several environmental and technological issues. Because of its elevated content in N, P, S and heavy metals, sewage sludge forms an excellent model compound for a biomass waste stream with high inorganic loading. Hence, the current study focuses on elucidating the distribution and environmental risks of a series of target inorganic components into the gas phase, char residue and condensate, upon sewage sludge gasification. Hereto, an experimental study will be performed on bench scale, including advanced and complimentary chemical analyses, both on-line and off-line (GC-TCD, FTIR, ICP-AES, X-ray microfluorescence, X-ray diffraction and elemental analysis). The obtained experimental data will be used to develop strategies for clean gas production by operation at selected temperature stages and to extend existing gasification models with reaction mechanisms for inorganic components. Finally, the gathered know-how will be verified and updated through a pilot scale study. In view of the project management, a detailed workplan is set up, split into five subobjectives. The project results will contribute to European excellence by the dissemination of research results through international publications, possible patents and a workshop, allowing an immediate and clear impact on technology and legislation development. The scientific project and its many complimentary training aspects will allow the candidate to pursue and consolidate a European research career in the fields of wastewater treatment and renewable resources on the long term.

Keywords: bio-fuels,biomass gasification,environmental chemistry,inorganic chemistry,instrumental techniques,reaction mechanisms and dynamics,renewable energies,waste conversion