Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Enabling the transition to 3D digital pathology (3DPATH)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Austria,Switzerland
Call: Transition Open 2024 (HORIZON-EIC-2024-TRANSITION-01, 2024)
Start date: 2025-04-01
End date: 2028-03-31
Duration (months): 36.0
Total project cost (EUR): 3090343.57
EU funding (EUR): 2493683.0
Participants: 3
Project status: SIGNED

Histopathology is a century-old standard for the diagnosis of cancer and other diseases, and for the choice of personalized treatments. Despite its paramount importance for clinical practice, this method is still limited to the analysis of thin slices, presenting a 2D view of the intrinsically 3D structure of biological tissue. Current histopathology practice poses the risk of severely undersampling relevant tissue features: indeed, a growing amount of data demonstrates that traditional 2D analysis produces inconsistent and unreliable results that may have important implications in treatment choice and other clinical decisions. Despite the compelling evidence of the clinical benefits of volumetric tissue analysis, clinical practice is still anchored to 2D imaging. A transition towards 3D inspection would be a quantum leap in the histopathology field but has been prevented hitherto because of technical limitations. Indeed, light-sheet fluorescence microscopy (LSFM) has been hailed in the last decades as a game changer in the field. However, LSFM-based solutions have profound limitations in terms of throughput, reliability and scalability that prevent their use outside specialised research labs. In 3DPATH, we want to leverage several key innovations in LSFM and data analysis technology – developed in previous research projects – to develop a 3D tissue scanner suitable for clinical use. The success of this project will revolutionize histopathology leading to more accurate diagnosis, improving quality of care for patients all over the world, and bringing Europe at the forefront of diagnostic technologies.

Keywords: 3d pathology,light sheet fluorescence microscopy,cancer diagnostics
Climate Neutral and Digitalized Laser Based Surface Functionalization of Parts with Complex Geometry (CLASCO)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Research and Innovation actions
Partnership: Made in Europe (co-programmed)
Countries involved: Germany,Spain,France,Ireland,Austria,United Kingdom
Call: Products with complex functional surfaces (Made in Europe Partnership) (RIA) (HORIZON-CL4-2022-TWIN-TRANSITION-01, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 4829772.5
EU funding (EUR): 4829772.5
Participants: 13
Project status: SIGNED

In the coming years, the European industry must assume the challenge of adopting clean and climate-neutral industrial value chains, producing sustainable products. Adopting digital systems will radically change the industry with products and services through innovative production processes. In particular, fully digitalised laser-based additive manufacturing methods are very versatile and thus can be implemented in different industries. Furthermore, energy saves against conventional manufacturing and material waste but also by design optimization can be achieved. However, these parts also required of additional surface treatments, which are nowadays energy and material-consuming, increasing costs and harming the environment. In addition, new concepts for increasing the added value of AM parts must be developed, for instance, by producing advanced surface functionalities in critical applications. The main objective of the CLASCO project is to develop a universal and digitalised laser-based post-process route for creating functionalised AM parts with complex shapes. While the complex parts will be produced by Laser Powder Bed Fusion, Laser polishing and laser surface micro-structuring using Direct Laser Interference Patterning will be combined in a unique manufacturing system. This route will substitute several resource-consuming processes, reducing the environment's negative impact. The implementation will allow substituting standard environmental non-friendly methods and even obtaining a better performance. In addition, different in-line monitoring methods, specifically plasma sensors and infrared cameras will be implemented. In this way, a virtual representation of the process for each part will be possible (digital twin), creating an entirely digitised product. The project's impacts will be analysed to optimise the sustainability of processes and products across the entire life cycle.

Keywords: surface functionalization,digitalised laser based process additive manufacturing laser polishing laser surface micro structuring in line monitoring sustainability of processes and products
Mechanism and targeting of topoisomerase regulatory interactions to arrest MYC-driven tumors (MYCinTOPshape)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2024-06-01
End date: 2029-05-31
Duration (months): 60.0
Total project cost (EUR): 1996750.0
EU funding (EUR): 1996750.0
Participants: 1
Project status: SIGNED

Inhibitors of DNA topoisomerases (TOPs, TOP1, TOP2) are mainstays of anticancer therapy. While they have proven effective, the toxicity of current TOP drugs, caused by DNA damage-induced apoptosis of non-cancer cells, limits their use in clinic. Development of tumour-specific TOP inhibitors will require a better knowledge of the mechanisms of TOPs. This research program aims to define how TOP are regulated during transcription and replication and develop drugs that target these regulatory mechanisms for anticancer treatment. TOPs promote transcription and replication by removing DNA supercoiling generated during polymerase elongation. In my works published in Cell and Molecular Cell, I have discovered that the activity of TOPs in the cell is regulated. The oncoprotein MYC joins TOP1 and TOP2 in a topoisome complex and stimulates their activities to remove the supercoiling produced during transcription and replication, thus boosting cellular proliferation. Therefore, I propose that targeting the mechanism of the topoisome instead of the single TOPs, will selectively halt MYC oncogenic function while preserving physiological TOP activity, avoiding the generation of DNA damage associated to current TOP drugs. By using new genomic tools to analyse DNA topology, advanced biochemical and microscopy approaches, as well as drug screens, I will define the mechanism of MYC-driven transcriptional/replicational acceleration via topoisome assembly, and develop drugs blocking topoisome activity to arrest tumour growth. I predict this proposal is feasible based on my excellent background, compelling preliminary data, and strong collaborations with scientists at KI and National Institutes of Health. The work will identify novel strategies to target TOPs that can be put forward in clinical trials for the benefit of society. This new way of targeting TOPs to affect MYC activity constitutes a beyond the state-of-the-art and ground-breaking approach to the field of cancer biology.

Keywords: topoisomerases,dna topology,myc,anti cancer drugs
FETALIX - REJUVENATING THE SPINE TO SET YOU FREE (FETALIX)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Portugal
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Joana Caldeira is a forward-thinking researcher, PhD in Biomedicine and FETALDISC’s CEO, whose passion is to contribute to the generalized life quality improvement of an increasingly ageing society. Following her expertise as a researcher in the field of extracellular matrix modulation, improving current regenerative therapies, namely intervertebral disc disease, Joana was faced with a problem that is many times overlooked: Low Back Pain (LBP). Although it may pose as a straightforward health condition to address, LBP, frequently caused by intervertebral disc degeneration (IVDD), affects up to 80% of the population, having a tremendous socioeconomic impact. This condition often requires expensive, lengthy, and invasive treatment, which rarely treats the underlying disease, impacting patient’s life quality by affecting mobility, ability to work and sleep. Moreover, this health challenge is also prevalent in the canines, with many breeds suffering from continuous pain, limited mobility, and immobilization at older ages. To address this challenge, Joana founded FETALDISC, LDA to mainstream innovative, and sustainable deep tech biomedical solutions, especially for IVDD treatment, having FETALIX as its core product – THE FIRST REGENERATIVE FETAL-INSPIRED BIOMATERIAL TO TREAT LBP. The solution will change the market dynamics, by achieving better intervertebral disc regenerative results, being more affordable and eliminating existing treatments setbacks. The company’s biggest challenge is to master business and market insights to track investors’ interest, undertake clinical trials, and certification, and thus launch FETALIX into the market. Women TechEU support will be paramount for the company’s business and market robustness, as well as its scale-up through consolidating its business model and plan, thus allowing the company to be fully prepared for the commercialization stage. Women TechEU will be part of the journey of REJUVENATING THE SPINE TO SET PATIENTS FREE.

Keywords: intervertebral disc degeneration lower back pain health deep tech fetal inspired biomaterial sustainable solution
Harnessing Non-Classical Carbocations for Stereoselective Synthesis (StereoCPC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-09-01
End date: 2030-08-31
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Stereoselective synthesis is a central aspect of modern organic chemistry, enabling the precise formation of specific stereoisomers in complex molecular architectures. Key to this process are reactive intermediates such as carbenes, radicals, and carbocations. However, achieving complete stereocontrol over non-classical carbocations in the stereoselective synthesis of acyclic molecules remains a formidable challenge. These fascinating carbocations, despite decades of research, exhibit unpredictable reactivity, making the controlled creation of stereocenters particularly difficult. In this proposal, our primary goal is to achieve comprehensive stereocontrol over non-classical carbocations. We plan to accomplish this by first identifying the specific substitution pattern necessary to generate these carbocations as a single isomer. Then, we will focus on precisely controlling their reactivity to form stereodefined adjacent C–X and C–C bonds at distant positions from the initial carbocation, through molecular rearrangement. This approach not only aims to tame the unpredictable nature of non-classical carbocations but also to harness their reactivities to create highly complex and defined acyclic molecular structures. Additionally, we aim to pioneer new strategies for synthesizing polysubstituted cyclobutanes, and strained fused ring system utilizing bismetalated species, an accomplishment that has never been achieved, despite the growing use of these structures as potential bioisosteres. These methods represent a significant advancement in the stereocontrolled synthesis of complex molecules, addressing longstanding challenges in regioselectivity, substitution patterns, and stereochemistry. By harnessing the unique reactivity of strained rings and non-classical carbocations, this research is set to unlock novel pathways to molecular architectures previously deemed unattainable, significantly enriching the synthetic toolbox of organic chemistry.

Keywords: non classical carbocation,stereochemistry,acyclic systems,cyclopropyl carbinyl cation,nucleophilic substitution,cyclobutene,housane,bicyclobutane,bicyclopentane,gembismetallated species
EVOLUTION OF THE COPERNICUS LAND SERVICE PORTFOLIO INTEGRATING NOVEL EO DATA AND LATEST MACHINE LEARNING ALGORITHMS TO CONTINUOUSLY MONITOR THE STATUS, DYNAMICS AND BIOMASS OF THE LAND SURFACE (EVOLAND)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Belgium,France,Austria,Germany,Slovenia
Call: Copernicus Land Monitoring Service evolution (HORIZON-CL4-2022-SPACE-01, 2022)
Start date: 2023-01-01
End date: 2025-12-31
Duration (months): 36.0
Total project cost (EUR): 4999531.26
EU funding (EUR): 4999531.25
Participants: 14
Project status: SIGNED

The Horizon Europe EvoLand (Evolution of the Copernicus Land Service portfolio) proposal aims at developing innovative methods, algorithms and candidate Copernicus Land Monitoring Service (CLMS) prototypes monitoring the status and changes of land use/land cover and various land surface characteristics at high spatial and temporal resolution. Specifically, EvoLand will address eleven next-generation CLMS product candidates by integrating innovative approaches in data fusion, Machine Learning, continuous monitoring and biomass mapping, as well as through integration of novel EO and in-situ data. EvoLand will analyse policy, data and infrastructure requirements for the prototype services by interacting with the relevant Entrusted Entities as well as the main Copernicus Land stakeholders and users. These requirements will steer all methodological developments. Algorithms will be developed, tested and implemented in an efficient, modular and scalable way on open-source infrastructure on various representative test sites, located both within and outside Europe. In a subsequent demonstration phase, the candidate services will be prototypically implemented over larger regions, focusing on key thematic domains such as agriculture, forest, water, urban and general land cover. Finally, all candidate services will be regularly analysed in view of their innovation and policy support potential, technical excellence, and operational readiness, and a strategy to transferring these services to operations will be proposed. The ambition of EvoLand is thus to support the Entrusted Entities by dedicated research, providing tangible proof of the evolution potential of the CLMS in terms of improved information content, quality and timeliness, and enable well-informed and facts-based decision-making on the future of the CLMS.

Keywords: copernicus land monitoring service,evolution,data fusion,machine learning,artificial intelligence,sentinel satellites,novel eo data,biomass mapping,open source
Dry-processing of metal halide perovskites into thin films (APERITIF)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2023-11-01
End date: 2025-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Perovskite semiconductors are promising for photovoltaics with a potentially very large market. Industrial compatible deposition processes that do not employ solvents are unavailable currently. We have developed a new deposition process, that is completely solvent free, compatible with a wide range of perovskite precursors, operates at moderate vacuum levels and leads to high quality films with crystal grains in the order of 500 nm. In the APERITIF project we aim to attract industrial sponsors, both equipment manufacturers and photovoltaic module producers to license this novel process and use it to build a larger scale prototype and implement it for larger area solar cells. To do this we will protect this process and the novel perovskite compositions and subsequent solar cells by filing patents. In view of the superior perovskite film quality we expect to obtain more efficient and stable photovoltaic devices. As the processing method is compatible with continuous operation it allows for high speed production, something that is urgently needed to address the enormous growth scenarios of photovoltaic panels
CArdiovascular Risk Assessment in MEnopausaL women via multimodal data analysis enabling personalized prevention strategies (CARAMEL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Research and Innovation actions
Countries involved: Spain,Colombia,Ireland,Lithuania,Finland,Israel,Belgium,Croatia,Greece,Italy,Portugal
Call: Personalised prevention of non-communicable diseases - addressing areas of unmet needs using multiple data sources (HORIZON-HLTH-2024-STAYHLTH-01-two-stage, 2024)
Start date: 2024-12-01
End date: 2029-11-30
Duration (months): 60.0
Total project cost (EUR): 14351412.63
EU funding (EUR): 11998512.63
Participants: 25
Project status: SIGNED

Women’s cardiovascular health is an urgent clinical unmet need as reported by the European Society of Cardiology (ESC), as cardiovascular disease (CVD) risk in women still tends to be underestimated by clinicians and women themselves. CVD is under-diagnosed, under-treated and poorly understood, more so in women in the 40-60 age group, when personalised risk assessment and prevention can have a positive impact on their health. In this context, CARAMEL will deliver an innovative personalised prevention model aimed at women 40-60yrs based upon a risk assessment stratification model considering sex and gender specific risk factors and a self-assessment and self-management approach using innovative digital technologies, empowering women to optimise their cardiovascular health. The proposed CVD-Risk Assessment and Stratification scheme will only be possible by the cumulative risk factors analysis, fueled by AI, emerging from a wide number of different data sources, including clinical data from EHR, medical imaging, biomarkers, metabolomics, lifestyle information (sleep, physical activity, diet) from large cohorts and biobanks. A consortium composed by 25 partners and Affiliated Entities coming from 11 countries, composed by 9 clinical entities, 6 research organisations and 10 industry and SMEs will develop, test and validate the personalised prevention program in observational and interventional studies in clinical sites in Colombia, Croatia, Greece, Lithuania and Spain. To that end, engagement of women aged 40-60, will take place from the onset on the co-design and co-creation of the studies and the self-management app ecosystem to be developed. Likewise, Gender in research will be mainstreamed all along the intervention. CARAMEL will also deliver policy recommendation and clinical guidelines supporting the design and update of CVD Plans by health authorities and healthcare providers, considering novel AI based risk models, applicable to women aged 40-60 yrs.

Keywords: artificial intelligence,ai,ml,big data,deep learning,diagnostics,women,risk models,mhealth,imaging
Incentivizing Citizen Exposure to Quality News Online: Framework and Tools (NEWSUSE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Poland
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-12-01
End date: 2029-11-30
Duration (months): 60.0
Total project cost (EUR): 1993125.0
EU funding (EUR): 1993125.0
Participants: 1
Project status: SIGNED

Populism, polarisation, and wavering support for democratic norms are pressing threats to the EU. NEWSUSE seeks to explain and remedy these threats by bringing the problem of insufficient news consumption to the forefront. Rather than focusing on echo chambers, misinformation, or filter bubbles, I argue that very low news use among citizens is a drastically overlooked problem, which leads to voting misaligned with individual interests and susceptibility to manipulative, populist and misinformed rhetoric. Brexit and the 2016 US election are key examples. Because greater news exposure can make citizens more resilient to the various democratic threats, it is urgent to address the fundamental question: How to sustainably incentivize the use of quality news? Toward this end, NEWSUSE advances a theoretically driven and applicable model that accounts for individual, algorithmic and social factors influencing news (non-)use and – therefore – also the approaches to promoting news intake. Building on this model, NEWSUSE designs validated computational tools to increase people’s consumption of quality news, pinpoints whether it is the citizens, social contexts, and/or recommender systems that need to be tweaked, and tests the democratic effects of increased news use across political contexts and social media platforms. NEWSUSE relies on cutting-edge multidisciplinary methods, combining quantitative and qualitative, observational and over-time experimental designs and incorporating the latest advances in computer and computational social science, the first project to apply these innovative approaches conjointly and comparatively. NEWSUSE advances academic knowledge and its findings will be crucial for scholars across disciplines, (non-)governmental organizations, and policymakers working on algorithmic transparency. It is only when we know how different factors together prevent or enhance news exposure, will we be able to make citizens and democracies more resilient.

Keywords: news media,news avoidance,media exposure,media effects,social media,digital platforms,algorithms,polarization,misinformation,software tools,attitudes,democracy,democratic resilience,citizenship