Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Automated Mechanical Peripheral Stimulation for motor rehabilitation in people living with Parkinson’s Disease (PD) (GONDOLA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Parkinson’s disease (PD) is a neurodegenerative brain disorder, characterised by the inability of a person’s brain to produce a neurotransmitter called dopamine, lessening a person’s ability to regulate body motions. PD affects 10m people globally, its prevalence is expected to double by 2040. There is no cure for PD, current therapies focus on treating symptoms that undermine patients’ quality of life. Costs associated with PD are higher than its prevalence, causing substantial economic burden on individuals, families and society. In 2004, the annual spending in Europe on PD was €10.7b. As costly as they are, these therapies improve motor symptoms in the early stages of PD, but over time, patients have more and more reduced response to medications and become more disabled. Thus, they cannot be considered as ideal with regard to efficacy, long-term effectiveness and safety. NINDS (part of the US NIH) set recommendations addressing Gait as one of the 3 top priorities for advancing basic clinical research on PD. We have aligned ourselves with NINDS’ strategy through development of GondolaTM. GondolaTM is a portable medical device made for people living with PD. It delivers a non-invasive neurostimulation treatment named Automated Mechanical Peripheral Stimulation (AMPS). It is based on physical neurostimulations of specific points in both feet, which allow to increase the afferent inputs from the peripheral nervous system to the spinal cord, and induce a better functioning of the central pattern generator (the mechanism that regulates movements in the body). Four clinical studies have documented that AMPS is effective in improving motor skills in PD, particularly slowness of movements and freezing of gait. Users have derived the following benefits from the device: Reduced Freezing of gait, gait hesitation, slowness of movements, improved independence, self-confidence, fluidity in walking and balance, reducing the risk of falls and improving the quality of life.

Keywords: parkinson s disease,freezing of gait,automated mechanical pheripheral stimulation,clinical trials,neuro rehabilitation,treatment of neurodegenerative diseases
Low-latency Perception and Action for Agile Vision-based Flight (AGILEFLIGHT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and communication engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Switzerland
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Drones are disrupting industries, such as agriculture, package delivery, inspection, and search and rescue. However, they are still either controlled by a human pilot or heavily rely on GPS for navigating autonomously. The alternative to GPS are onboard sensors, such as cameras: from the raw data, a local 3D map of the environment is built, which is then used to plan a safe trajectory to the goal. While the underlying algorithms are well understood, we are still far from having autonomous drones that can navigate through complex environments as good as human pilots. State-of-the-art perception and control algorithms are mature but not robust: coping with unreliable state estimation, low-latency perception, real-time planning in dynamic environments, and tight coupling of perception and action under severe resource constraints are all still unsolved research problems. Another issue is that, because battery energy density is increasing at a very slow rate, drones need to navigate faster in order to accomplish more within their limited flight time. To obtain more agile robots, we need faster sensors and low-latency processing. The goal of this project is to develop novel scientific methods that would allow me to demonstrate autonomous, vision-based, agile quadrotor navigation in unknown, GPS-denied, and cluttered environments with possibly moving obstacles, which can be as effective in terms of maneuverability and agility as those of professional drone pilots. The outcome would not only be beneficial for disaster response scenarios, but also for other scenarios, such as aerial delivery or inspection. To achieve this ambitious goal, I will first develop robust, low-latency, multimodal perception algorithms that combine the advantages of standard cameras with event cameras. Then, I will develop novel methods that unify perception and state estimation together with planning and control to enable agile maneuvers through cluttered, unknown, and dynamic environments.

Keywords: micro aerial vehicles,drones,computer vision,event cameras,machine learning
AQUA4D - For an efficient use of irrigation water (AQUA4D)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Switzerland
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2018-12-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Water is becoming scarcer, droughts are becoming a big problem, and together with high levels of soil salinization and nematodes infections, are endangering the agriculture sector all around the world. Planet Horizon Technologies (PHT) presents a Swiss-made innovative, chemical-free and eco-friendly solution to face agricultural problems: AQUA4D. The basic principle of AQUA4D technology is the change of water structure with electromagnetic (EM) waves. This technology has proved to be highly effective in the horticulture and fruit sector. Now, PHT aims to expand the use of this technology to the main crops sector (cereals and grains). To do so, we adapted the current modular system to cope with higher flow-rates of water needed for sprinkler irrigation systems – a market that was valued as 1.57 B€ and it is expected to grow at a CAGR of 14.97% during the period 2017-2022. AQUA4D facilitates a better dissolution and distribution of minerals, promotes water retention in the soil and allows for absorption of minerals by the plants, allowing 25% reduction on water and fertilizer use. At the same time, AQUA4D increases the natural resistance of plants against diseases, avoids nematode attacks in roots and prevents clogging and biofilm in pipes. AQUA4D presents the lowest power consumption (able to be powered with small solar panels) and the lowest running cost from all water treatment technologies in the market, allowing its use in a low margin market such as the main crops production. The result expected will be an improvement of up to 20% in the production yield with a fast payback, between 6 and 24 months. Commercialization of high flow rate AQUA4D is estimated to begin in 2020 and PHT estimates to sell 9,000 units during 2020-2024 period, which will render us a cumulative gross profit of 40.50 M€ by 2024.

Keywords: electro magnetic treatment,agricultural irrigation,irrigated water,water savings,fertilizer savings,brackish water,agricultural production yield,crops,cereals
Cracking the Code for Protein Quality Control Mechanisms Recognizing Exposed Hydrophobicity in Protein Substrates (HyDegronomics)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Israel
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-02-01
End date: 2026-01-31
Duration (months): 60.0
Total project cost (EUR): 1801490.0
EU funding (EUR): 1801490.0
Participants: 1
Project status: SIGNED

Proteostasis is a highly regulated process by which cells maintain a healthy proteome. Loss of proteostasis is a common feature of aging and disease. To preserve proteostasis, the cell has developed protein quality control (PQC) pathways that monitor a proteins’s fate from synthesis to degradation. Exposed hydrophobic residues in aberrant or mislocalized protein substrates is a key feature recognized by distinct PQC mechanisms. If not handled properly, exposed hydrophobicity can result in protein aggregation and subsequent reduced cell fitness. To prevent accumulation of toxic aggregates, cells are equipped both with chaperones and proteolytic pathways. Within the degradation systems, E3 ligases are the major determinants of specificity, which is achieved through their selective recognition of specific short peptide motifs, or degrons, in substrate proteins. Despite the growing list of PQC players and substrates, it has yet to be determined what are the client range, selectivity and specificity of each of the PQC mechanisms. The objective of this proposal is to systematically investigate the exposed hydrophobicity “code” and to advance the state-of-the-art of the PQC field. Here, we utilize the GPS-peptidome method that we recently developed together with genetics, biochemistry, cell biology and proteomic approaches to: (1) map distinct classes of hydrophobic degrons to elucidate the specificity of substrate selection; (2) identify novel E3 ligases playing a role in PQC pathways, explore redundancies among them and identify endogenous substrates proteome- wide; (3) investigate the physiological significance of PQC mechanisms. This work will provide a comprehensive view of PQC pathways that recognize hydrophobicity. This is critical to further our understanding on how aberrant features in proteins are recognized and can provide valuable information for the development of new therapeutic intervention strategies that target abnormal proteins implicated in disease.

Keywords: protein degradation,protein quality control,ubiquitination,e3 ligase,degron,hydrophobic residues
Automatization of perturbative QCD at very high orders. (PertQCD)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Switzerland
Call: ERC Advanced Grant (ERC-2015-AdG, 2015)
Start date: 2016-10-01
End date: 2021-09-30
Duration (months): 60.0
Total project cost (EUR): 2045095.0
EU funding (EUR): 2045095.0
Participants: 1
Project status: CLOSED

In recent months, we broke new ground in perturbative Quantum Chromodynamics computing for the first time a physical cross-section of a hadron collider process - Higgs production - at the fourth order in the strong coupling constant expansion. This breakthrough improved the perturbative precision of a fundamental cross-section by a factor of four, paving the way for a very precise testing of the Standard Model theory against LHC data. The aim of our proposal is to fully automate all calculations which are needed for LHC and future collider physics at similarly high perturbative orders. Our work will improve the precision of theoretical predictions across the spectrum of LHC phenomenology, matching or superseding the accuracy of experimental measurements. In turn, we will be able to draw firm conclusions about the validity of theories which aspire to describe nature at TeV energies and search confidently for signals of new physics through precision measurements at the LHC.
Enabling simpler, cheaper and more efficient energy conversion for power electronics modules (Hey3012)

Framework: Horizon 2020 — Societal Challenges
Action type: SME instrument
Countries involved: France
Call: H2020-EIC Accelerator pilot –SME Instrument - Green Deal (H2020-EIC-SMEInst-2018-2020-4, 2020)
Start date: 2020-07-01
End date: 2023-06-30
Duration (months): 36.0
Total project cost (EUR): 3482500.0
EU funding (EUR): 2437750.0
Participants: 1
Project status: CLOSED

Today’s society relies more and more on electricity, which is essential to power our homes, portable devices, and for our mobility via electric vehicles and bikes. To meet this growing demand for electricity, there are two solutions: increase production, or reduce energy losses in the distribution between production and consumption. The latter solution is becoming possible with the recent advent of wide band gap materials such as silicon carbide in the power electronics industry. SiC promises significant benefits such as high energy conversion efficiency and smaller device size. This leads for example to extended driving ranges in electric vehicles and more efficient generation of solar power. However, the potential of SiC has not yet been fully exploited. With a significant improvement to a key, yet overlooked, mandatory component of all electronic power devices, the gate driver, Heyday Integrated Circuits enables to fully leverage the potential of silicon carbide. HeyDay introduces Hey3012, the only gate driver with the revolutionary patented Power-Thru technology enabling the full potential of silicon carbide devices. Hey3012 delivers 4 key benefits: less conversion losses, less components, less volume and less cost. Heyday is targeting the growing market for isolated gate drivers estimated at €1.8B by 2025. Albeit small, this market has a major impact on the much bigger power electronics market (€40B in 2025). That is due to the ubiquity of power modules: electric vehicles, solar panels, robotics, data servers, power supplies and many other applications. Heyday will start Hey3012 sales in 2022 focusing on 3 key markets: automotive, solar and industrial motors, with respective time-to-markets of 4, 2.5 and 1.5 years. Heyday is a French company founded in 2014 with the mission of enabling the most efficient and safe energy conversion. Heyday has raised €2M in private funding so far and targets 25% of the isolated gate driver market.

Keywords: electricity conversion,silicon carbide,gate driver,power electronics
Cleansing the Library: the Expurgatory Censorship of Books in Europe (Science and Humanities, 16th-18th cent.) (CLEANLIB)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2017-12-31
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

This research project presents the issues related to the Inquisition censorship over books, to cleanse them of danger and impurities during the 16th-18th centuries in Europe. It aims at answering the question of what was actually done, how and why; to assess the effectiveness and tell the history of early modern expurgation, or microcensorship, of the contents, and the connections between the tools used by the control system, the indexes of prohibition and expurgation; to edit the latter, printed in the 17th century. Given the vastness of the bibliographical field, the framework of the research focuses on two disciplines: Science and Humanities. The testing ground of the specific methodological introduction and rare books’ exploration produced objective results and certainties about its accuracy and efficiency. Microcensorship studies can be initiated as a critical contribution to the general history of censorship, with a large historical and geographical perspective. The IEF two year-training project is completed in a research centre in Barcelona. Spain was the dominant country in the early modern expurgation technology; this strategic city is located at the critical crossroads of censoring and correcting cultures using the same means. A systematic exploration of the local and national libraries and archives will provide information on an unprecedented scale. Moreover, censorship studies represent an important part of Spanish research. Thanks to its newness, this project can potentially intensify international cooperation, intra- and extra-European cooperation, to enrich doctoral training. The matter intrinsically interconnects disciplines, cultures and societies, and is related to non academic activities. Being a large-scale undertaking in early stages, the aims of this field of research are to be institutionalized, expanded and internationally adopted. CleanLib meets the demand for knowledge sharing and dissemination, and is relevant to the H2020 Program.

Keywords: inquisition,print culture,correction,book market
Defining hormonal cross-talk and the role of mutations in estrogen receptor positive breast cancer (ER_disease)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: United Kingdom
Call: ERC Consolidator Grant (ERC-2014-CoG, 2014)
Start date: 2015-06-01
End date: 2020-05-31
Duration (months): 60.0
Total project cost (EUR): 1987273.75
EU funding (EUR): 1987273.75
Participants: 1
Project status: CLOSED

Estrogen Receptor (ER) is the driving transcription factor in ~75% of all breast cancers. ER antagonists are routinely used for treatment, but significant variability exists in clinical response. We are interested in explaining this heterogeneity and exploiting the mechanistic insight. We have recently identified important, but previously uncharacterised cross-talk between ER and the progesterone receptor (PR) and androgen receptor (AR) pathways, both of which are commonly expressed in ER+ tumours. Recently, ER has been shown to be mutated in ~18-55% of metastatic breast cancers. In addition, two key ER-chromatin regulatory proteins, FoxA1 and GATA3, are mutated in primary ER+ disease. Finally we have discovered three previously unknown phosphorylation events on FoxA1. Aim 1: We will comprehensively explore the cross-talk that exists between ER and PR and AR pathways to determine the physiological effects on ER function. Aim 2: We will recapitulate the key mutations observed in ER, FoxA1 and GATA3, to assess the impact on ER-DNA interactions, ER transcriptional activity and cell growth and drug response. This will be explored under different hormonal contexts to identify how the mutational spectrum influences the cross-talk between ER and the parallel PR and AR pathways. Aim 3: We will identify upstream kinase pathways that influence FoxA1 and GATA3 function. Aim 4: We will establish a novel single locus chromatin purification method for isolation of specific chromatin loci, followed by Mass Spectrometry to characterise the potential role of PR and AR variants and to identify unknown regulatory factors. Given recent biological discoveries and technological advances, we are perfectly positioned to apply cutting-edge tools to glean mechanistic insight into the factors that determine variability within ER+ disease. This proposal aims to advance our understanding of ER+ tumour heterogeneity, revealing ways of exploiting this in a clinically meaningful manner.

Keywords: biochemistry and molecular mechanisms of signal transduction,proteomics,epigenetics and gene regulation
models, EXperiments and high PERformance computing for Turbine mechanical Integrity and Structural dynamics in Europe (EXPERTISE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Germany,Germany,Spain,Italy,Türkiye,France,Czechia,Czechia,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2017-03-01
End date: 2021-08-31
Duration (months): 54.0
Total project cost (EUR): 3815947.44
EU funding (EUR): 3815947.44
Participants: 12
Project status: CLOSED

Energy and Mobility are two primary driving forces in the 21st century. Development of incremental and disruptive technologies will have key impacts on the world’s societies, and on safety, security and competitiveness of Europe. Amongst those technologies, gas turbines will play a major role. Recovery of shale gas depends decisively on compressors. Modern gas supplied power plants are bridging towards the age of renewable energies. Aeroengines are to undergo the most massive changes in their history with the advent of composite materials, gear boxes, and turbine-electric concepts separating generation of power and thrust. A technological commonalities of the upcoming challenges is the need for full model based development and computer system simulation. There is agreement on this in the computational fluid dynamics (CFD) community. The structural dynamics and vibration questions are at present far from being addressed adequately. While US agencies and Asian powers have already started to prepare themselves, European research organisations and companies still seem to be too fragmented to reach critical research ressources and start corresponding initiatives. There are two main reasons for this. First, the physics of mechanical joining technologies that dominate the damping behavior of the large-scale structures under debate, are still poorly understood. Second, there is a lack of high performance computing (HPC) capabilities in structural dynamics, which goes back to the lack of knowledge of effective HPC technologies for structural dynamics. Since the US, China and India have started efforts in the field, we propose a European contribution through a Marie Curie ETN to allow a first generation of early stage researchers to catch up on the topics, ideally open up new fields of insight and approaches, and finally form a seed group for the upcoming challenges of the European turbine industry with respect to nonlinear structural dynamics and HPC.

Keywords: structural dynamics,friction damping,joints modeling,turbomachinery,parallel computing