Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding resistance to immune checkpoint inhibitors by mapping the tumor-host ecosystem at single-cell resolution (cellsIMPACT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Belgium
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-05-01
End date: 2022-04-30
Duration (months): 24.0
Total project cost (EUR): 178320.0
EU funding (EUR): 178320.0
Participants: 1
Project status: CLOSED

The fashion for tanned skin (in western countries) goes hand in hand with a high risk of getting melanoma: the most dangerous skin cancer. The recent development of novel classes of immunotherapies such as immune checkpoint blockade (ICB) for oncology has brought up hopes for the treatment of advanced-stage melanoma patients. Targeting immune checkpoints has reached remarkable clinical benefit in multiple cancers (especially in melanoma), enabling life extension and even complete remission in some cases. However, one of the current major limitations of ICB is that they cause durable clinical responses only in a relatively small number of patients and the reason behind this is still poorly understood. The central goal of this project is to discover novel and robust biomarkers predicting response to ICB as well as to understand the molecular mechanisms underlying therapy resistance (either intrinsic or acquired). I propose to establish dynamic maps of the evolving tumor ecosystem, including the tumor microenvironment (TME) landscape, at single-cell resolution during adaptive response to ICB. Pre- and on-treatment biopsies and blood samples from stage IV melanoma patients are currently being serially collected. I will analyze single cell RNA/DNA sequencing data obtained from these samples and integrate them with staining data from multiplex immunohistochemistry of the melanoma tissue. I will apply novel bioinformatic and statistical approaches to reach the ultimate aim: integration of the above-mentioned data with patient’s clinical characteristics and identification of unknown patterns (biomarkers) associated with responses to ICB, an urgent unmet clinical need. My expertise in melanoma immunology and in the analysis of large clinical datasets will be instrumental for the successful completion of this project.

Keywords: melanoma,single cell sequencing,checkpoint blockade
Exploiting supramolecular interactions in phthalocyanine chemistry (PhthaloSupra)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-10-01
End date: 2019-10-22
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

The present project aims at realizing a significant step forward in the use of noncovalent interactions as a “tool” to self-assemble phthalocyanines (Pc), planar and aromatic macrocycles which possess several unique physicochemical properties such as an intense absorption in the red/near-infrared region of the solar spectrum, a rich redox chemistry, and a tuneable bandgap. In PhthaloSupra, the fellow will prepare stable Pc-based supramolecular polymers self-assembled though the combination of pi-stacking, and hydrogen or halogen bonding interactions, noncovalent interactions which have never been used “simultaneously” to self-assemble in a controlled fashion Pc derivatives into supramolecular polymers. For such ensembles, he will study some fundamental properties such as their self-assembly mechanism, light-harvesting capability, and helical chirality, all aspects that are raising nowadays a great deal of scientific attention. The photovoltaic properties of some of the prepared architectures will also be investigated contributing to address the European and international growing interest towards reducing energy consumption through the realization of smart materials for low-cost optoelectronic technologies. Diffusion of the PhthaloSupra achievements will be given not only to specialized researchers, but also, an importantly, to the general public in the form of several outreach activities. Undoubtedly, the opportunity for the candidate to work in a group of the highest scientific quality such as the one of Prof. Torres, and in a highly multidisciplinary and challenging project such as PhthaloSupra will strengthen his potential to mature further to an independent, highly trained researcher. Moreover, he will develop transferable skills, such as research management and organization, competencies which will help him to function more effectively in multidisciplinary and multicultural environments, thus improving his career perspectives.

Keywords: phthalocyanine,self assembly,supramolecular interactions,hydrogen bonding,halogen bonding,pi stacking,donor acceptor ensembles,photovoltaics,supramolecular polymers,chirality
Studies of Materials and Catalysts by Dynamic Nuclear Polarization Enhanced Solid-state NMR (DNPMAT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-05-01
End date: 2019-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Recent innovations in dynamic nuclear polarization (DNP) have transformed the sensitivity of solid-state nuclear magnetic resonance (NMR), resulting in a reduction in experiment time of up to 100,000-fold. This means that previously unobtainable structural details can be quickly obtained by NMR, even for dilute species, such as binding sites in catalysts or functionalizing molecules at surfaces. The objectives of the action are the improved sample preparation protocols, new experimental approaches and proof of principle studies necessary to make DNP-enhanced solid-state NMR the method of choice for the molecular-level characterization of the surfaces of materials. These objectives will be achieved by knowledge exchange between Dr S. Chaudhari, an experienced researcher with a background in developing DNP, and researchers at the University of Nottingham involved in solid-state NMR studies of materials and catalysts. The action is designed to train Dr Chaudhari though high-quality research into applications of DNP-enhanced solid-state NMR to four technologically useful materials: mesocellular silica foams, alumina catalyst supports, surface-coated hydroxyapatite nanoparticles and model catalytic converters. The training will take place at the state-of-the-art UK Facility for DNP-enhanced solid-state NMR operational at the University of Nottingham since November 2015. The Facility’s instrumentation is unique in the UK and is available to external users from both industry and academia, resulting in a vibrant research environment and a ready-made network of collaborators for Dr Chaudhari. In addition, a secondment at a leading sustainable technology company (Johnson Matthey) will ensure that industrial and commercial aspects are fully integrated into the action. The training will transform Dr Chaudhari into a creative and independent scientist working at the frontiers of DNP-enhanced NMR by providing him with the necessary research knowledge and transferable skills.

Keywords: solid state nuclear magnetic resonance,dynamic nuclear polarization
Understanding the role of the rainbow trout metagenome on growth and health in aquaculturally farmed fish (HappyFish)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-08-01
End date: 2020-07-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Aquaculture is the fastest growing food-producing sector world-wide: >50% of consumed fish are farmed and the increasing human demand for high quality protein will continue. The most important challenge for securing continued development of green aquaculture is sustainable solutions to improve feed efficiency as feed makes up >50% of the total cost for producing a fish. Further, animal protein is increasingly substituting plant based ingredients for fish feed; this has yet unknown effects on related metabolic processes affecting growth and health. Promising solutions for optimizing feed efficiency and fish health stem from recent studies that sequence metagenomes (combined microbial DNA in the host gut) to detail out how the complete gut microbiome (the microbial community in the gut) interacts with metabolic and immunological pathways in human and mice; results that have revolutionized the way we understand how microbes affects human health. Identification of beneficial bacteria holds a huge potential for optimizing feed efficiency and boost immunity in farmed fishes. The aim of this project is to pursue this potential. I will apply a multidisciplinary approach using metagenomics to describe, for the first time, the complete metagenome of the rainbow trout gut. This combined genomic resource will be coupled with carefully planned feeding experiments to identify associations with the host trout gut-microbiota and i) animal vs. plant based diets, ii) genes of the host fish, and iii) individual growth and metabolic traits such as growth rate and fat content of the host trout. Results will yield new knowledge on microbe-host interactions in rainbow trout and may lead to new products (e.g. probiotics and fish feed) enhancing fish health by actively modulating the microbiota. The project will additionally establish trout as a general model for the study of how modulation of the microbiota can give rise to increased health and meat quality in any farmed animal.

Keywords: metagenomics,green aquaculture
Gut microbiota-dependent tryptophan metabolism: role in disease pathogenesis and therapeutic target (MODulATE)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: France
Call: ERC Starting Grant (ERC-2016-STG, 2016)
Start date: 2017-03-01
End date: 2022-08-31
Duration (months): 66.0
Total project cost (EUR): 1495525.0
EU funding (EUR): 533816.25
Participants: 3
Project status: CLOSED

Tryptophan (Trp) is an essential amino acid required for protein biosynthesis and is also a biochemical precursor of metabolites which have major effects on mammalian physiology. In the gastrointestinal tract, Trp metabolism can follow three major pathways, all of which are under the control of the gut microbiota: (i) the kynurenin pathway in immune and epithelial cells via indoleamine 2,3-Dioxygenase 1, (ii) the serotonin production pathway in enterochromaffin cells via Trp hydroxylase 1 and (iii) the direct use of Trp by the microorganisms of the gut microbiota into several molecules including ligands of the Aryl Hydrocarbon Receptor. The end products of these pathways play key roles in modulating the immune response, intestinal and metabolic functions and behaviour. Several diseases which involve the gut microbiota in their pathogenesis are also impacted by Trp metabolite. This suggests that the effect of the microbiota in these diseases could be at least partially mediated by impaired Trp metabolism. We recently observed that impaired Trp metabolism by the gut microbiota is involved in inflammatory bowel disease pathogenesis and preliminary data suggest a potential role in other major human diseases. The aims of the current proposal are (i) to identify the components of the gut microbiota, including both bacteria and fungi, involved in the control of the 3 Trp metabolism pathways in the gut, (ii) to decipher the reciprocal equilibrium between the pathways and to evaluate the potential of its modulation as a therapeutic target, and finally (iii) to assess the relevance of these phenomena in human patients. This challenging project will involve multi-disciplinary aspects, from microbiology to metabolism, inflammation and medicine, the use of multiple cutting edge technologies and translational analysis from mice to human. Beside scientific importance, it will have societal impact by identifying new therapeutic strategies in several human diseases with unmet needs.

Keywords: gastroenterology,intestinal homeostasis,microbiota,inflammatory bowel disease
Feasibility Study for INTELEG® S HF – a Wide Pressure Range Process Gas Analysis System (INTELEG S HF)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Lithuania
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-11-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The fast growing thin and ultra-thin film industries largely rely on modern vacuum-based processes, which often exhibit fast and slow process gas composition changes and drifts. Such changes are undesirable and can result in reproducibility and product quality issues. Various control strategies, relying on proper monitoring systems (such as Gas Analysis Systems [GAS]), can be employed to stabilise production processes at the desired working point by regulating gas flow and thus adjusting gas composition. However, currently existing GAS are rather limited and there is no solution available on the market that provides gas composition information reliably in the process pressure range between 0.1 and 10,000 mTorr as well as provide 24/7 non-stop operation. Furthermore, ultra-thin film market has been exponentially growing: by 2024 it is expected to grow at CAGR of 15.1%; up to €99.78 bn. Due to the growing demand for reliable wide-range GAS solving the existing shortcomings, Nova Fabrica has developed a miniature high-frequency plasma-OES-based gas analysis system INTELEG® S HF. It enables to measure the gas composition of vacuum-based processes in the pressure range from 0.1 up to 10,000 mTorr. It is expected that INTELEG® S HF will be the first single GAS instrument in the world capable to provide process gas analysis for PVD, CVD, ALD, IAD, etc., as well as for processes taking place in even lower vacuum at pressures up to 10,000 mTorr. Comparing to competing solutions, a breakthrough INTELEG® S HF solution offers a true global “down-stream” process gas analysis, 24/7 operation, 100,000 hours of mean time before failure, fulfilment of industry 4.0 requirements, competitive price, has no production downtime and is maintenance-free. The main objectives of Phase 1 of SME Instrument are to develop an elaborate feasibility study including technical feasibility testing, IPR strategy and business plan – crucial steps towards successful commercialisation of the solution.

Keywords: miniature plasma,gas analysis,high frequency,quality monitoring,thin films,ultra thin films,vacuum based processes
Unification of treatments and Interventions for Tinnitus patients (UNITI)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Understanding health, wellbeing and disease
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Spain,Spain,Italy,Germany,Cyprus,Belgium,Greece,Sweden,Switzerland,Hungary
Call: Systems approaches for the discovery of combinatorial therapies for complex disorders (H2020-SC1-2019-Two-Stage-RTD, 2019)
Start date: 2020-01-01
End date: 2023-09-30
Duration (months): 45.0
Total project cost (EUR): 5989343.75
EU funding (EUR): 5989343.75
Participants: 15
Project status: SIGNED

Tinnitus is the perception of a phantom sound and the patient’s reaction to it. Tinnitus remains a scientific and clinical enigma of iTinnitus is the perception of a phantom sound and the patient’s reaction to it. Although much progress has been made, tinnitus remains a scientific and clinical enigma of high prevalence and high economic burden. It affects more than 10% of the general population, whereas 1% of the population considers tinnitus their major health issue. Recent cohort studies show that tinnitus prevalence tends to increase over time and with older age. Assuming that there is no cure to be found, the prevalence estimates in Europe would double by 2050. A large variety of patient characteristics - including genotyping, aetiology, and phenotyping - are poorly understood, because integrated systems approaches are still missing to correlate patient`s characteristics to predict responses to combinatorial therapies. Although genetic causes of tinnitus have been neglected for decades, recent findings of genetic analysis in specific subgroups (gender and phenotype) have highlighted that bilateral tinnitus in men reached a heritability of 0.68. This heritability is close to autism, schizophrenia and Attention Deficit Hyperactive Disorder (ADHD). There is no current consensus on tinnitus treatment. UNITI’s overall aim is to deliver a predictive computational model based on existing and longitudinal data attempting to address the question which treatment approach is optimal for a specific patient based on specific parameters. Clinical, epidemiological, medical, genetic and audiological data, including signals reflecting ear-brain communication, will be analysed from existing databases. Predictive factors for different patient groups will be extracted and their prognostic relevance will be tested in a randomized controlled trial (RCT) in which different groups of patients will undergo a combination of therapies targeting the auditory and central nervous systems.

Keywords: tinnitus,personalized medicine,complex disorder,biobank
Renewable Energy and Connectivity Hub (REACH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 2584375.0
EU funding (EUR): 1809062.5
Participants: 1
Project status: CLOSED

While in the developed regions availability of electricity power has paved the way of sustainable development, it is still not available to ca. 18% of the world population, living in rural areas in developing countries and refugee camps worldwide. No access to power indicates exhausting effort for covering basic needs, which impedes sustainable social and economic development. Nearly 700 million people worldwide have mobile phone connections but no access to the electricity. In India, people belong to off-grid communities need to travel approximately 15 km to get their mobile phone charged. We have developed a unique solar power based Hub system and remote payment control mechanism by which electronic devices can be charged under the control of a central server to ensure accountability and transparency. This will enable EU companies to enter in €8 to 10 billion untouched market by delivering essential internet-based services (e.g., e-health, e-education, e-governance etc). BuffaloGrid supplies Hubs free of cost to local agents. This will stimulate local enterprise, encourage entrepreneurship and boost economic development. During SMEi Phase – 1 feasibility study, we have identified several technical improvements that are mainly focused on further development of the Hub, PCB and server designs. For commercial feasibility of the project, we have successfully performed market research, environmental impact assessment, partnership establishment, risk analysis and competitor analysis. During this project, we aim to reach from TRL7 to TRL9 and will make the product ready for mass scale deployment. We will focus on technical design improvement of the Hub for cost reduction (60%) and will finalise optimised system for mass scale production. We will also validate Hub functionality and server operations and will trial online services of EU SMEs in the field. Our commercialization plan is to deploy minimum 50,000 hubs across India, Sub-Sahara Africa and Refugee camps by 2021.

Keywords: social business,off grid internet,community economic development,micro enterprise
EARTH OBSERVATION FARMING (EO-FARM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Action type: SME instrument
Countries involved: Italy
Call: SME Instrument (H2020-SMEINST-1-2014, 2014)
Start date: 2014-10-01
End date: 2015-03-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

EOFARM project will cover the topic of Precision Farming (PF), one of the main applications of Earth Observation in the agriculture industry; it makes use of satellite images to help farmers in monitoring and managing crops from planting to harvesting. One of the main needs of farmers, in particular smaller ones which account for 80% of the UAA in EU27, is the possibility to increase yields while reducing the costs and environmental impacts of current crop production processes. EOFARM main objective is to launch in the market an innovative PF service which targets small farms (average size between 5-30ha), addressing a clear user need, and to enter in the emerging market of commercial applications of EO downstream services in agriculture, estimated to be worth approximately € 43 million in 2015. EOFARM will be based on: -an innovative algorithm able to integrate the algorithm indexes derived from NDVI(Normalized Difference Vegetation Index), LAI (LEAF AREA INDEX) and OSAVI (Optimized Soil-Adjusted Vegetation Index) for the production of 3 different kind of maps at the same time: crop vigor maps, vegetation status maps, green leaf maps, - free satellite data derived from the constellation Copernicus (sentinel 2) and Landsat 8 - Open Geo, an open source solution The impact on the EU Market of agriculture will be huge, considering that the current market for commercial applications of EO downstream services in agriculture is about € 34 million and the estimated EO downstream services Total Addressable Market (TAM) for the Agriculture sector amounts to approximately € 0,4 billion. In this context The EOFARM project is expected to boost IPTSAT growth in terms of turnover, EBIDTA and employment opportunity. Additionally EOFARM will have positive impacts on the small farmers by increasing productivity and sustainability by means of improved resource efficiency: it will possible to use less water, energy, fertilisers (especially phosphorus and nitrogen) and pesticides

Keywords: precision farming pf,earth observation,agriculture industry,constellation copernicus,sentinel2,open geo open source solution,innovative algorithm,ndvi,lai and osavi