Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Mediterranean critical Infrastructure Resilience Engineering with Nature based solutions (Med-IREN)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Adaptation to climate change
Destination: Adaptation to climate change
Action type: Innovation actions
Countries involved: Greece,Italy,Finland,Belgium,Portugal,Spain,France,Cyprus,Bulgaria,Germany,Switzerland,United Kingdom
Call: Testing and demonstrating transformative solutions to protect critical infrastructure from climate change, mainstreaming nature based solutions. (HORIZON-MISS-2023-CLIMA-01, 2023)
Start date: 2024-10-01
End date: 2028-09-30
Duration (months): 48.0
Total project cost (EUR): 11466040.0
EU funding (EUR): 10353273.25
Participants: 32
Project status: SIGNED

The Med-IREN project aims to provide actionable demonstration on how to climate proof the Mediterranean critical infrastructures, across critical sectors, by introducing NBS both in terms of improving climate risk management and sustaining their business continuity to extreme climate change. The project will be showcased in five lighthouse regions across the Mediterranean, each corresponding to a present day challenge, that are aligned with regional policies and can constitute the EU as a global leader in the field. Med-IREN will cover different and diverse types of CI (energy, transport, water, ICT, social) , priority climate hazards within the Mediterranean, which is a climate hot-spot, and NBS interventions. In parallel, the interventions and solutions will be replicated into four more regions across the EU, covering the Mediterranean, Black Sea and Boreal regions. Med-IREN will also provide evidence how key enabling conditions, such as participatory governance and citizen engagement, novel forms of financing, innovative urban/landscape planning and capacity building will support regional systemic transformation nd provide the upscaling and replication mechanism within Mediterranean regions and beyond. A high-end digital decision making support toolset will be developed, integrating data from multiple sources, both in-situ and E.O., applying state-of-the-science models, as well as providing unprecedented visualization and sensemaking capabilities for understanding and quantifying resilience through-out the infrastructure and NBS life-cycle. Med-IREN will rely on the integration of the research output of more than 15 European and National projects, that focused on the (climate) resilience of infrastructures, regional adaptation and implementation of NBS. Med-IREN is conceived as a powerful showcase of the EU twin green & digital transition and an immediate success story of the EU Green Deal.

Keywords: critical infrastructures,climate resilience,transformative,more systemic adaptation,disaster risk reduction,nbs
Multifunctional Cavity Mirrors for Next-Generation Ultra-Stable Lasers (MightyMirrors)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Systems and Communication Engineering
Panel description: Electrical, electronic, communication, optical and systems engineering
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-05-01
End date: 2030-04-30
Duration (months): 60.0
Total project cost (EUR): 1972500.0
EU funding (EUR): 1972500.0
Participants: 1
Project status: SIGNED

Ultra-stable laser cavities (USLCs) lie at the heart of humankind’s most precise measurement instruments. Developing compact, multi-wavelength, USLCs will greatly benefit applications such as quantum sensing, spectroscopy, metrology, and quantum computing. In this research program, I propose to explore novel versatile cavity mirrors by integrating low-noise meta-devices with multi-layer photonic integrated circuits into complex laser resonator geometries. I envisage a fully integrated USLC by incorporating all necessary sensors, modulators, and input-output optics within the mirror substrate. Innovative laser resonator topologies will allow for pushing the stability limits into new regimes and gaining access to novel application fields of optical cavities. We have recently demonstrated an optical cavity incorporating an ultra-low-noise meta-mirror with an unprecedented cavity finesse of >11,500. These developments are possible thanks to our theoretical framework to model thermal noise processes in arbitrary optical systems. High-refractive index materials, like silicon, diamond, silicon nitride, and aluminum oxide, are ideal for realizing low-noise meta-devices and integrated photonic circuits. The enormous conceptual and technological challenges lie in simultaneously controlling many properties (optical, optomechanical, thermal) in complex photonic configurations incorporating different materials and addressing various temperature ranges and multiple wavelengths within a single miniaturized cavity. Through its research program, the MightyMirror project will enable a symbiosis of integrated photonics and free-space cavities, opening many new possibilities with a large impact on fundamental and applied science as well as on society.

Keywords: high precision optical metrology,ultra stable laser cavities,precision spectroscopy,quantum technologies
Support for the organisation of EU-US symposia in the field of Transport Research (SYMPEUS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Mobility
Destination: Clean and competitive solutions for all transport modes
Action type: Coordination and support actions
Countries involved: Sweden,Belgium,Germany
Call: Support for the organisation of EU-US symposia in the field of Transport Research (HORIZON-CL5-2023-D5-01, 2023)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 749397.59
EU funding (EUR): 622744.01
Participants: 3
Project status: SUSPENDED

Support for the organisation of EU-US symposia in the field of Transport Research The main objective of the SYMPEUS CSA is to strengthen collaboration in transport research between the EU and the US. The project is closely working with the EC in organising four EU-US Transport Research Symposia: in Washington DC (2024, 2026), in Brussels (2025, 2027). The project will support the symposia participation of the European transport community and will work together with DG RTD and DG MOVE for managing these 3-day events in terms of organisation, content development, reporting. At each event, 25 experts from EU and US, respectively, will discuss and elaborate R&I recommendations on a theme agreed between the EC and US DoT. SYMPEUS will involve and collaborate with all relevant European actors – researchers, industry, users, innovation leaders, etc., and consult key transport players including European Technology Platforms in transport and relevant Horizon Europe partnerships. For each symposium SYMPEUS’s will: • Define overall planning on the EU side (preparation, execution, dissemination of the symposia) • Consult with stakeholders to identify EU expert candidates, to be proposed to the EC, • Manage expert invitations, registrations, travel costs reimbursements, • Prepare communication material, • Provide support in drafting of preparatory documents, design of symposia, programme, • Offer facilitation for the symposium and its break-out sessions. • Provide support in editing, quality management, dissemination of the conference proceedings reports. Additionally, for the two symposia to be held in Brussels, SYMPEUS will manage the overall local organisation including selecting and covering costs for venue, catering and logistics. The lump sum project is managed by a consortium of 3 organisations with complementary competences, experiences and structures: VTI (Swedish public institute), ECTRI (European association) and VDI/VDE-IT (German private research agency).

Keywords: transport mobility research sustainability competitiveness open strategic autonomy horizon europe international collaboration european union united states of america
Evasion-aware Detection Sandbox (EVADES)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2024-03-01
End date: 2025-08-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Mobile malware is getting harder and harder to detect. This is one of the reasons why malicious apps regularly appear on the official Play Store, despite the considerable effort Google and the security industry put into early detection and validation of each application. To mitigate this problem, EVADES aims to combine a number of novel techniques developed as part of the ERC BitCrumbs project into the first evasion-resilient, scalable, and maintainable sandbox to analyze Android applications. Our current prototype outperforms all open-source and commercial competitors, showing a significant technological advantage over the current market. We already performed preliminary experiments and the results we obtained are as worrisome for users as they are encouraging to justify a business idea. In fact, 70% of the Android malware we tested with our technology implemented some form of evasion targeting existing malware analysis tools. This shows that the data we are using today to decide whether applications are benign or malicious is completely unreliable. The EVADES project will focus on transforming our prototype server-side component into production software, developing the missing client-side components required to produce an MVP, and exploring different ways we could sell and monetize our technology. We are certain that our solution has the potential to revolutionize the Android security market by providing a more accurate and scalable way to collect information about the behavior of applications. This is paramount for any mobile security solution, as well as for existing and future machine learning-based approaches that today struggle to use the ‘unreliable‘ information provided by existing dynamic analysis systems.
Governance and business models for living labs: rural regeneration hubs for tackling soil health challenges in the Mediterranean region (GOV4ALL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Mission
Theme: Soil health and food
Destination: Soil health and food
Action type: Research and Innovation actions
Countries involved: Spain,Netherlands,Greece,France,Switzerland,Serbia
Call: Co-creating solutions for soil health in Living Labs (HORIZON-MISS-2023-SOIL-01, 2023)
Start date: 2024-06-01
End date: 2028-11-30
Duration (months): 54.0
Total project cost (EUR): 11953240.43
EU funding (EUR): 11953115.0
Participants: 37
Project status: SIGNED

In the EU, 60-70% of soils are degraded as a direct result of unsustainable management. However, tackling this multifaceted challenge is not an easy task, mainly because farmers' decisions are influenced by a wide range of factors, making it difficult to define regenerative soil management practices that are simultaneously effective, economical, have demonstrable yield benefits and are easy to implement. In this context, the goal is to foster a collective awareness, at the the level of five Mediterranean regions, that soils and humans must be understood as social-ecological systems and that no organisation/solution alone is capable of sustainably transforming the system. The desired change can only emerge when the innovation process is supported by an exploration phase enabling actors to identify their personal (from individuals to organisations) drivers, ultimately aligning purposes and behaviours toward impactful collective actions. To demonstrate this, the project will apply co-creation tools to multi-actor governance structures, emphasising the building up of a shared awareness of soil threats over the identification of specific technologies. The main objectives of the proposed plan are: 1) to explore regional needs and drivers, and to validate governance models for operating multi-actor co-creation processes; 2) to establish a network of five agro-innovation hubs sustained by underlying business models; 3) to define harmonised regional baselines for 7 out of the 8 indicators found in the Soil Mission Implementation plan; 4) to kick-start the multi-actor co-design and validation of solutions for soil health that are practical and scalable; 5) to facilitate the diffusion of innovation through a plethora of communication and dissemination actions. GOV4ALL concentrates on 3 Mediterranean pedo-climatic zones, where the hubs will serve as sustainable innovation centres, aiding the Soil Mission's objectives and inspiring soil regeneration regionally and beyond.

Keywords: governance
Intelligent design of adenovirus vectors (iAds) (iAds)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: France,Netherlands,Spain,Sweden,United Kingdom,Lithuania
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-05-01
End date: 2027-04-30
Duration (months): 48.0
Total project cost (EUR): 3959506.68
EU funding (EUR): 3959506.68
Participants: 9
Project status: SIGNED

Advanced therapies, and in particular gene therapies, hold great potential for treating diseases for which few options exist. Efficient gene transfer is inherently and intransigently linked to vector efficacy. Partially due to the lack of suitable delivery systems for particular applications, the success of too many gene therapies is limited. Over the last two decades, immense progress has been made in the development of viral vectors. Importantly, this progress has also identified vector characteristics and biological factors that decrease efficacy. While limited efficacy is relevant for all vector platforms, it is more pressing in the case of adenoviruses because they have so much potential. In some cases, host responses and imperfect targeting have stunted adenovirus vector development for therapies that require long-term transgene expression. Our multi-faceted consortium proposes an innovative approach to overcome these limitations and to construct a pathway for developing improved vectors for clinical gene transfer. By synergising French, Dutch, British, Spanish and Swedish expertise in structural biology, receptor engagement, neurobiology, cardiobiology, and bioprocessing, we will create in silico designed intelligent adenovirus vectors (iAds). Our disruptive concept abandons the classical approach of developing vectors from naturally occurring adenoviruses. Instead, a proprietorial adenovirus type will be serially stripped of unwanted elements to create a bank of iAds, which will then be engineered for heart- and brain-specific targeting. Our consortium blends academic ingenuity and SME/pharma manufacturing that will allow seamless clinical translation. With the support of the EIC Programme, our ground-breaking approach should revolutionise gene transfer and generate solutions in areas of unmet medical need via a platform that exploits the full potential of viral vectors.

Keywords: gene therapy,adenoviral vectors,technological innovation,cardiovascular disease,neurodegenerative disorders
A bioprinting platform for the rapid, reliable, controlled and quantifiable patterning of cellular aggregates and microtissues into macroscale regenerative grafts with programmable architectures (m2M)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Unlocking the full potential of new tools, technologies and digital solutions for a healthy society
Action type: Research and Innovation actions
Countries involved: Ireland,Netherlands,Finland,Germany,Portugal,Austria,New Zealand,Switzerland
Call: Bio-printing of living cells for regenerative medicine (HORIZON-HLTH-2024-TOOL-11, 2024)
Start date: 2024-12-01
End date: 2028-11-30
Duration (months): 48.0
Total project cost (EUR): 7999068.75
EU funding (EUR): 7999068.75
Participants: 13
Project status: SIGNED

A fundamental limitation with current approaches aiming to bioprint tissues and organs is an inability to generate constructs with truly biomimetic composition and structure, resulting in the development of engineered tissues that cannot execute their specific function in vivo. This is perhaps unsurprising, as many tissues and organs continue to mature postnatally, often taking many years to attain the compositional and structural complexity that is integral to their function. A potential solution to this challenge is to engineer tissues that are more representative of an earlier stage of development, using bioprinting to not only generate such constructs, but to also provide them with guiding structures and biochemical cues that supports their maturation into fully functional tissues or organs within damaged or diseased in vivo environments. It has recently been demonstrated that such developmental processes are better recapitulated in ‘microtissues’ or ‘organoids formed from self-organizing (multi)cellular aggregates, motivating their use as biological building blocks for the engineering of larger scale tissues and organ. The main goal of micro2MACRO (m2M) is to develop a new bioprinting platform capable of spatially patterning numerous cellular aggregates or microtissues into scaled-up, personalised durable load-bearing grafts and guiding their (re)modelling into fully functional tissues in vivo within damaged or diseased environments. This will be achieved using a converged bioprinting approach capable of rapidly depositing cells and microtissues into guiding scaffold structures with high spatial resolution in a rapid, reliable, reproducible and quantifiable manner. These guiding structures will then function to direction the fusion and remodelling of cellular aggregates and microtissues into structurally organised tissues in vitro and in vivo, as well as providing medium-term (3-5 years) mechanical support to the regenerating tissue.

Keywords: cartilage osteochondral maxillofacial bioink microtissue melt electrowriting inkjet extrusion
Kefiran: Harnessing Exopolysaccharide bioActivities beneficiaL To Health (KHEALTH) (KHEALTH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-02-23
End date: 2028-02-22
Duration (months): 24.0
Total project cost (EUR): 252728.64
EU funding (EUR): 252728.64
Participants: 1
Project status: SIGNED

KHEALTH will unlock the potential of kefiran, an exopolysaccharide (EPS) from kefir grains, a symbiotic microbial community used as a starter culture to produce the fermented beverage kefir. Thanks to recent scientific evidence of its health benefits, the popularity of kefir is rising, especially post-COVID-19. Although many studies document the health benefits of consuming kefir, the health-related attributes of kefiran have not been extensively studied. Kefiran is an EPS composed of D-glucose and D-galactose whose structure and bioactivities are strictly related to the producing microbial strain. Despite the general lack of research, preliminary studies of EPS from lactic acid bacteria show promising bioactivities such as antimicrobial and prebiotic effects. KHEALTH will screen ~200 strains from the kefir collection of Teagasc Food Research Centre to identify high-yield kefiran producers, followed by in vitro/ex vivo assays to assess bioactivities (e.g., antimicrobial, antioxidant, prebiotic, cholesterol-lowering). Structural analysis of kefiran will correlate with its bioactivities, filling knowledge gaps relating to EPS structure-function relationships. The project will proceed to develop scalable kefiran production strategies, including the exploitation of dairy industry by-products as fermentation substrates for kefiran production, thereby aligning with the EU's Circular Economy Action Plan. Genetic engineering approaches will be applied to further investigate approaches to enhance kefiran production. KHEALTH will also involve an in vivo animal study of kefiran's health benefits, with the final aim of harnessing its health-promoting potential. A comprehensive Dissemination, Exploitation & Communication plan will ensure the findings reach both the scientific community and society. The implementation of KHEALTH will also greatly contribute to the career development of the researcher in academia through implementation of a detailed Career Development Plan.

Keywords: kefir,exopolysaccharide,kefiran,bioactivities,yield optimization
Towards the next generation of high performance li-ion battery cells (NEXTCELL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Energy
Destination: Cross-sectoral solutions for the climate transition
Action type: Research and Innovation actions
Partnership: Batteries (co-programmed)
Countries involved: Germany,Belgium,France,Austria,Italy,Slovenia,Spain,Norway,Portugal
Call: Advanced high-performance Generation 3b (high capacity / high voltage) Li-ion batteries supporting electro mobility and other applications (Batteries Partnership) (HORIZON-CL5-2021-D2-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 7995015.47
EU funding (EUR): 7995015.47
Participants: 21
Project status: SIGNED

The Li-ion battery (LIB) market is now entering a period where energy density improvements and cost reductions are levelling off for the current generation 3a. To continue with this trend while keeping pace with the increasing industry demands for cost reduction, user-friendliness of electric vehicles and safety, breakthrough innovations at material level and cell design are needed. Within this context, NEXTCELL overarching goal is to provide a new 3b LIB cell generation for both high capacity and high voltage applications developing and validating a ground-breaking gellified cell concept. The project workplan revolves around a three dimension-based methodology: (i) Prototyping the gellified cell concept up to TRL6 (20Ah), (ii) Modelling the gellified cell concept, and (iii) Evaluation of technical, safety, sustainability, and costs improvements. NEXTCELL’s approach will not only provide Europe with cutting edge 3b cells but will also tackle three key parameters hindering a greater market penetration of LIBs technology: (i) Costs: optimising its manufacturing processes, reducing capital and operating costs of future Giga-factories by avoiding evaporation of solvents and the electrolyte-filling step. (ii) Safety: Producing intrinsically safe cells, avoiding the presence of low boiling point components in cell components. (iii) Sustainability: Reducing energy consumption by 50% against SoA and avoiding the use of toxic organic solvents (NMP). The project is led by the electric vehicle industry, from the project coordination by FEV (leading vehicle and powertrain international service provider) to key industry manufacturers along the value chain, such as SOLVAY (polymer, binders, and separators), ABEE (cathode production), VARTA (LIB manufacturer) or CRF (research centre for the Fiat Chrysler Automobiles group). Thus, NEXTCELL has a solid determination towards fast and successful commercialisation of the novel cell design and its new components after the project.

Keywords: electrochemisty,li ion batteries,cell design,high energy density