Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The first portable, low-cost, robotized scanner microscope that converts any smartphone into a high quality and intelligent tele-microscopy image diagnosis system (MicroSpot)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Spain
Call: Open Disruptive Innovation Scheme (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2018-02-01
End date: 2018-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Healthcare accounts for approximately 10% of global gross domestic product. While the average life expectancy increases and some diseases are disappearing, other diseases raise. Cost of healthcare is a major economical challenge leading to unequal distribution of health benefits, which starts with the access to medical diagnosis. This situation and the new industrial revolution creates an opportunity to transform and innovate in the healthcare domain. MicroSpot is the first portable, low-cost, robotized scanner microscope that converts any smartphone into a high quality and intelligent microscopic image diagnostic system. MicroSpot is connected to a cloud ecosystem, capable of real time streaming and remote control and an artificial intelligence assistant for image analysis. MicroSpot aims to replace the actual obsolete equipment and processes used in microscopic medical image diagnosis while revolutionizing current manufacturing methods. MicroSpot democratizes the access to clinical image diagnosis by creating a new generation of medical devices that reduces time, costs and distances bringing microscopic image diagnostics closer to the point of care.

Keywords: microscopy,diagnosis,3d printing,artificial intelligence,remote control,mobile app,collective intelligence
Training network in drug discovery targeting TRIM Ubiquitin ligases in disease (TRIM-NET)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Spain,Italy,Italy,Belgium,France,Netherlands,Netherlands,United Kingdom,United Kingdom
Call: Innovative Training Networks (H2020-MSCA-ITN-2018, 2018)
Start date: 2019-01-01
End date: 2023-06-30
Duration (months): 54.0
Total project cost (EUR): 3203448.48
EU funding (EUR): 3203448.48
Participants: 14
Project status: SIGNED

The TRIM-NET innovative training programme will provide Early-Stage Researchers with the skills to identify novel therapeutic targets and develop the strategies to validate them in preclinical studies. Integrating complementary expertise and multidisciplinary approaches TRIM-NET aims to address this goal, focussing on the Tripartite motif (TRIM) family of Ubiquitin E3 ligases, which plays an important role in many physiological processes. The importance of the role of TRIM proteins in these processes is underpinned by their recognised involvement in many disease processes such as cancer, neurodegeneration and rare genetic diseases. As such, they are excellent targets for therapeutic manipulation. The TRIM-NET consortium created a critical mass with complementary and interdisciplinary expertise, from Life Science to Chemistry, around this family of proteins to identify and exploit common targeting strategies for translational applications. The consortium is designed to train a cohort of researchers in skills and expertise essential for biomedical research in the era of personalised medicine, focussing on determining how: i) TRIM proteins contribute to disease; ii) to develop strategies to modulate TRIM proteins activity; iii) to design high throughput screening assays for drug discovery. The training programme comprises 7 highly integrated work packages: 4 scientific and 3 dedicated to training, dissemination and management. The proposal consists of 12 individual research projects that will form the basis of the research training aspects for the ESR recruited to the programme. As the scientific work packages are highly integrated, recruited ESRs will avail of techniques and training opportunities, including secondments, across the work packages. Through a unique international partnership between academic and non-academic partners the TRIM-NET training programme will provide ESRs with skills that are essential for future biomedical research in industry and academia.

Keywords: ubiquitination,e3 ligases,drug discovery,peptide chemistry,biomaterials synthesis
TACTIle feedback enriched virtual interaction through virtual realITY and beyond (TACTILITY)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Italy,Italy,Spain,Serbia,France,France,France,France,Netherlands,Denmark
Call: Interactive Technologies (H2020-ICT-2018-3, 2018)
Start date: 2019-07-01
End date: 2022-09-30
Duration (months): 39.0
Total project cost (EUR): 3799946.25
EU funding (EUR): 3799946.25
Participants: 12
Project status: CLOSED

TACTILITY is a multidisciplinary innovation and research action with the overall aim of including rich and meaningful tactile information into the novel interaction systems through technology for closed-loop tactile interaction with virtual environments. By mimicking the characteristics of the natural tactile feedback, it will substantially increase the quality of immersive VR experience used locally or remotely (tele-manipulation). The approach is based on transcutaneous electro-tactile stimulation delivered through electrical pulses with high resolution spatio-temporal distribution. To achieve it, significant development of technologies for transcutaneous stimulation, textile-based multi-pad electrodes and tactile sensation electronic skin, coupled with ground-breaking research of perception of elicited tactile sensations in VR, is needed. The key novelty is in the combination of: 1) the ground-breaking research of perception of electrotactile stimuli for the identification of the stimulation parameters and methods that evoke natural like tactile sensations, 2) the advanced hardware, that will integrate the novel high-resolution electrotactile stimulation system and state of the art artificial electronic skin patches with smart textile technologies and VR control devices in a wearable mobile system, and 3) the novel firmware, that handles real-time encoding and transmission of tactile information from virtual objects in VR, as well as from the distant tactile sensors (artificial skins) placed on robotic or human hands. Proposed research and innovation action would result in a next generation of interactive systems with higher quality experience for both local and remote (e.g., tele-manipulation) applications. Ultimately, TACTILITY will enable high fidelity experience through low-cost, user friendly, wearable and mobile technology.
Single-Crystal Perovskite Tandem Solar Cells For High Efficiency and Low Cost (Crystal Tandem Solar)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United States,United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2019-12-31
Duration (months): 36.0
Total project cost (EUR): 269857.8
EU funding (EUR): 269857.8
Participants: 2
Project status: CLOSED

This project aims to produce next-generation solar cells surpassing 30% power conversion efficiency at low cost, a much needed cheap renewable energy source. Initial rapid progress in the field of perovskite solar cells has slowed; efficiencies are not high enough to make them commercially attractive. Therefore, a step change is needed in how these devices are made. All perovskite solar cells so far are polycrystalline. The project will focus on solution-based epitaxial growth of single crystal perovskites, providing novel high quality thin films. These crystals will be incorporated into Si-based tandem solar cells, to form highly efficient single-crystal-on-single-crystal devices. Fabricating on top of an existing technology offers rapid commercialisation and significantly better power to cost ratio than existing technologies. The project will comprise an outgoing phase in Prof. Michael McGehee’s group at Stanford University, whose unrivalled expertise in fabrication of hybrid tandem solar cells will be combined with the researcher’s skills to fabricate single crystal perovskite-on-Si solar cells. The expertise obtained will then be transferred to the group of Prof. Sir Richard Friend at the University of Cambridge, experts in photophysics. The physical mechanisms occurring in these devices will be elucidated via ultrafast spectroscopy. Based on these findings, devices will be further improved to attain the highest efficiencies. The project addresses Horizon 2020's goals on clean and sustainable energy. The researcher is uniquely suited for this ambitious project, having strong expertise in perovskite and nanocrystal fabrication. It represents a novel combination of the fields of crystal growth, state-of-the-art device manufacture, and device spectroscopy. It will create strong links between the groups and ensure transfer of expertise into the European community. There is strong potential for intellectual property generation and industrial involvement.

Keywords: solar cells,photovoltaics,perovskites,crystal growth,single crystals,shape control,epitaxial growth,tandem solar cells,ultrafast spectroscopy,advanced characterisation,device physics
Extended University Alliance Doctoral Training Alliance in Energy, Applied Biosciences for Health and Social Policy DTA3 (DTA3)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: United Kingdom
Call: Co-funding of regional, national and international programmes (H2020-MSCA-COFUND-2017, 2017)
Start date: 2018-06-01
End date: 2023-11-30
Duration (months): 66.0
Total project cost (EUR): 13027680.0
EU funding (EUR): 6513840.0
Participants: 1
Project status: SIGNED

The DTA3 will develop 83 early-stage researchers (ESRs) as internationally connected, independent researchers with interdisciplinary and inter-sectoral skills and experience, ready for industrial employment in the European and UK priority challenge areas of healthcare, clean energy and social policy. Building on existing individual doctoral programmes, DTA3 is delivered through a consortium of 12 universities across England and Wales, with associate partners in Europe and Australia. COFUND will support the full integration of three existing individual programmes of training in applied biosciences for health, energy and social policy. This will increase the employability gains for graduate ESRs, who will benefit both from deep subject expertise and a broad understanding of the global challenges in these three key sectors. This responds to identified employer needs and will enable ESRs to transfer quickly and easily into a range of industry roles across the globe after their study. DTA3 provides access to expertise and research equipment across 12 institutions and an additional layer of cross-disciplinary training opportunities. ESRs will graduate from the programme with a solid grasp of the context of their skills and knowledge in the global labour market, and an international professional community of peers and employer networks. Thus, the over-arching ambition of DTA 3 is the development of a mobile, interdisciplinary and international ESR community able to solve grand challenges by working across healthcare, energy and social policy sectors. It seeks to build a cohort with broad connections to professional networks, industry and commerce across these three key sectors. Core objectives have been identified: - Development of a mobile, interdisciplinary & international ESR community able to solve grand challenges - Focus on communication & translation of applied research - Involve supervisors as an integral part of the programme

Keywords: doctoral,training,researcher,career development,energy,applied biosciences for health,social policy
A disruptive machine to enable mass production of composite parts (SIRA)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-09-01
End date: 2020-02-29
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Composite materials have the potential of simplifying aerospace & automotive structures. For example, a metallic car body out of 200 parts can be reduced to only 10 composite elements. This leads to large investment & process costs reductions, boosting the competitiveness of these industries while providing them exceptional lightweight to improve fuel economy and to enhance the electric vehicle market by increasing their range. However, state of art manufacturing technologies are not suitable for a full scale industrialization. AEON-T´s machine, SIRA, is the key to make this possible. AEON-T is a spinoff of Technical University of Madrid (UPM), the result of more than 5 years of technology development focused on solving the problem of industrial production of composite parts. With a highly skilled team, the resources of UPM and other leading research institutions in Madrid such as Carlos III University and Institute IMDEA Materials, AEON-T has managed to be among the 10 finalists out of more than 120 companies worldwide in the leading international startup competition at the JEC World 19 Composites Show. The company is currently opening the automotive market, performing concept tests with Voith Composites, a leading company in this industry, with the goal of introducing SIRA machine in the manufacturing line of said company in München, Germany, and other future customers that AEON-T is currently reaching.

Keywords: composites,preforming,carbon fiber,mass production
Dissecting and Overcoming Innate Immune Barriers for Therapeutically Efficient Hematopoietic Stem Cell Gene Engineering (ImmunoStem)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Italy,Italy
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-03-01
End date: 2025-02-28
Duration (months): 72.0
Total project cost (EUR): 1994375.0
EU funding (EUR): 600000.0
Participants: 2
Project status: SIGNED

The low gene manipulation efficiency of human hematopoietic stem cells (HSC) remains a major hurdle for sustainable and broad clinical application of innovative therapies for a wide range of disorders. Indeed, high vector doses and prolonged ex vivo culture are still required for clinically relevant levels of gene transfer even with the most established lentiviral vector-based delivery platforms. Current and emerging gene transfer and editing technologies expose HSC to components potentially recognized by host antiviral factors and nucleic acid sensors that likely restrict their genetic engineering and contribute to broad individual variability in clinical outcomes observed in recent gene therapy trials. Nevertheless, specific effectors are yet to be identified in HSC. We have recently identified an antiviral factor that potently blocks gene transfer in HSC and have discovered small molecules that efficiently counteract it. This is the first example of how manipulating a single host factor can significantly impact gene transfer efficiencies in HSC but likely represents the mere tip of the iceberg of the plethora of innate sensing mechanisms potentially hampering genetic manipulation of this primitive cell compartment. This proposal aims to identify the antiviral factors and innate sensing pathways that prevent efficient modification of HSC and to mitigate their effects using methods developed through a thorough understanding of their mechanisms of action. My approach builds on the innovative concept that understanding the crosstalk between HSC and viral vectors will instruct us on which immune sensors and effectors to avoid and how, with direct implications for all gene engineering technologies. Successful completion of this project will deliver broadly exportable novel paradigms of innate pathogen recognition that will allow ground-breaking progress in the development of cutting-edge cell and gene therapies and to fight infectious and autoimmune diseases.

Keywords: haematopoietic stem and progenitor cells,innate immunity,viral vectors,nucleic acid sensing,genetics
Between rediscovery and recreation: Renaissance accounts of medieval Italian vernacular literary tradition (1476-1530) (ReMedIt)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-01
End date: 2021-08-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

ReMedIt aims to provide the first historical reconstruction of the evolution of views on the medieval Italian vernacular literary tradition in Italy during the period that leads to the formation of an established canon of vernacular literary authors (1476-1530). The project focuses on the reception of the poetic tradition, in particular the extensive Italian lyric tradition (c. 1230-c. 1330) preceding Petrarch, one encompassing over two hundred authors. The project interrogates three main interrelated research strands: 1) the differing value judgements concerning the vernacular poetic past before Petrarch, both implicit ones (such as the selection of poets, their ordering, and the amount of attention afforded them in different poetic anthologies) and explicit comments and judgements; 2) the complex processes – material, interpretative, exegetical and cultural – that bring about the recovery of the medieval lyric tradition and generate knowledge related to it; and 3) the literary influence that this tradition exercised upon verse production during the same period 1476-1530 in the output of nine authors. In order to reconstruct the differing views regarding the genesis and historical development of the earlier Italian literary tradition, the project offers a novel interdisciplinary approach. It does this by integrating the study of how Renaissance poets were influenced by thirteenth- and fourteenth-century authors with an assessment of their critical reception and of the contemporary processes of recovery of their texts. In doing so, ReMedIt will offer a fuller and enriched understanding of this seminal period in the development of the history and codification of the vernacular literary tradition, thereby providing a case study that will be valuable for the study of other national literatures. Through a carefully constructed training-through-research programme the experienced researcher will expand her research interests broadening her chronological range.
General readout electronics for cross-sectoral application in European research infrastructure (GenEl)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-04-08
End date: 2022-06-08
Duration (months): 24.0
Total project cost (EUR): 174806.4
EU funding (EUR): 174806.4
Participants: 1
Project status: CLOSED

To attract the brightest minds and host outstanding research projects, facilities like the European Organisation for Nuclear Research CERN or the currently constructed European Spallation Source ESS are key. Experimental setups use cutting edge technology and process enormous amounts of data to reveal new discoveries. Infrastructures as detectors and computing centers are work horses but cannot operate without readout systems with high-end electronics. The goal of this project is to develop general readout electronics for cross-sectoral application. This approach overcomes the shortcoming that most experiments have to develop readout systems on their own and allows groups with little knowledge and capabilities in electronics to build world-leading experiments. The successful and well suited Scalable Readout System with the VMM chip, implemented by the candidate at CERN within the Horizon2020 projects AIDA2020 and BrightnESS as a prototype, will be transferred to the host institute. Indispensable knowledge on instrumentation and involvement in future experiments is provided in return. Upcoming European R&D projects and experiments across disciplines like particle and nuclear physics at CERN, neutron science at ESS, medical instrumentation as well as groups in the USA, China, Russia and Japan intend to use the final system. With a professor as experienced supervisor, the outstanding research infrastructure at the host institute and a secondment in a company, the system will be completed and commercialised. The implementation in world-leading experiments will be supported and results disseminated to scientific communities and general public. The project strengthens the European research infrastructure and demonstrates its capabilities globally. It is in line with the European Strategy for Particle Physics, ESS and other users' timelines. In addition, training on teaching, management and supervision will boost the applicant's career in direction of an independent group.

Keywords: cross sectoral readout electronics