Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Gestural Origins: Linguistic Features of pan-African Ape Communication (GESTURALORIGINS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC Starting Grant (ERC-2018-STG, 2018)
Start date: 2019-03-01
End date: 2025-05-31
Duration (months): 75.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Understanding the origins of language speaks to the fundamental question of what it means to be human. Other species’ communication contains rich information exchange; but humans do more than broadcast information. Language is used to communicate goals to partners, it goes beyond information: it has meaning. Only great ape gestures show similarly systematic meaningful communication; they are essential to understanding how human language evolved. Beyond meaning, two core features of human language are social learning and syntactic structure. These are universals, present across cultures. We all learn words and how to use them from others, leading to languages and dialects. We all use syntax; expressing different meanings by recombining words. In fact, these two features are common in animal communication: sperm whales learn songs from others; finches re-order notes into different songs. But, in a significant evolutionary puzzle, both appear absent in the communication of our closest relatives. The discovery of meanings in ape gesture resulted from studying ape communication under the challenging natural conditions that allow its full expression. A single study of a single group: it was the tip of the iceberg. Employing pan-African data across 17 ape and 9 human groups. I will tackle three major objectives. (1) Is there cultural variation in ape gesture? We will look at how species, physical environment, and social interaction affect how apes acquire and use gestures. (2) When apes combine signals, does it change their meaning? Moving beyond sequential structure we will look at how apes combine signals to construct meaning, and how the speed, size, and timing of gestures impacts meaning. (3) Human-ape gesture. We will investigate adults’ and children’s use and comprehension of gestures to compare them directly to other apes. Using new and established techniques across a dramatically wider sample I will address the fundamental question of how human language evolved.

Keywords: language evolution,comparative cognition
Elucidation of tumour cell plasticity mechanisms associated to treatment in metastatic prostate cancer (PDX-PC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Australia,Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2019-09-16
End date: 2021-09-15
Duration (months): 24.0
Total project cost (EUR): 166202.88
EU funding (EUR): 166202.88
Participants: 2
Project status: CLOSED

Prostate cancer (PC) is among the top five leading malignancies causing cancer mortality worldwide. Increased prevalence and declined mortality rate have led to an increment in follow-ups with a significant rise in the economic burden. In the last few years, several new options for metastatic disease have been approved leading to clinicians to have multiple choices of therapy sequences. However, not all patients initially respond and most of them eventually develop resistance. The ability of tumour cells to reprogram themselves and survive despite the blocked targets (tumour cell plasticity) may accounts for the absence of durable responses. In addition, the fact that initial treatments may affect the potential benefit of subsequent treatments highlights the need to discover predictive biomarkers for optimal treatment selection, allowing early changes in treatment for non-responding patients. This multidisciplinary project aims to elucidate the molecular mechanisms responsible for tumour cell plasticity associated to treatment response in metastatic PC. Patient-derived xenografts (PDX) in vivo models will be used, since they preserve molecular heterogeneity and therapeutic response observed in the clinic. They will be treated under different regimens. Tumour tissues will be analysed by RNA sequencing before and after treatment. Bioinformatics analysis will be used to establish molecular signatures of treatment response that will be validated in liquid biopsy (circulating tumour cells and cell free DNA) from metastatic PC patients undergoing different treatments. PDX-PC will provide a better understanding of the molecular evolution of the disease that will contribute to design more specific and individualized treatments. In the setting of non-curative therapy, the implementation of such molecular findings at clinical practice may help to guide treatment decisions, improve outcomes, and prevent unnecessary side effects and costly therapies in men with metastatic PC.

Keywords: metastatic prostate cancer,treatment resistance,tumour cell plasticity
Soccermatics: data for football fans and clubs (SOCCERMATICS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-08-01
End date: 2019-01-31
Duration (months): 18.0
Total project cost (EUR): 125318.75
EU funding (EUR): 125318.75
Participants: 1
Project status: CLOSED

Data plays an increasingly important role in sport, from monitoring of fitness of athletes to success statistics in baseball. In football (soccer) the team performance is more important than the performance of any one individual. While every team has its star players, it is the ability of the team to function as a unit that is the key to its success. For the data analyst, this presents a challenge: how to measure, understand and improve team performance. My research during an ERC funded action (IDCAB) has revolved around devising exactly this type of analysis methods. Starting with my work on measuring and understanding animal groups in the ERC action, I have gone on to develop a set of tools for looking at the collective action on the football pitch. In May 2016 my popular science book, Soccermatics, will be published by Bloomsbury press. This book details some of the work on football analysis I have done up until now, and will give me, and Soccermatics, significant name recognition. But it is jus a starting point: the idea of this PoC proposal is to develop a set of commercial tools for both clubs and fans to better understand football. I will use data provided by sports performance company Opta to provide consultancy to football clubs, online football analysis for fans and copyright protected applications for visualising football. I will build the business through three initial projects: (1) visualisation for online content; (2) a ‘manage your own team’ app; (3) football club analysis tools. The business will be focussed first on the UK market and scale up to a European and World market. The main innovation highlights of the action are: 1, Methodology for data analysis established during ERC starting-grant action. 2, Visually striking and intuitive approach to football data. Giving fans and clubs what they want. 3, Multiple avenues for commercialisation. 4, Scalability through delivery of copyrighted software.

Keywords: football,collective motion,visualisation,online content
PROs GRowing Europe through best practice SolutionS for Technology Transfer (PROGRESS-TT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Access to risk finance
Action type: Coordination and support actions
Countries involved: Italy,Spain,Germany,Italy,Switzerland,Finland,Netherlands,Netherlands,United Kingdom
Call: Capacity-Building in Technology Transfer (H2020-CBTT-2014, 2014)
Start date: 2015-01-01
End date: 2017-12-31
Duration (months): 36.0
Total project cost (EUR): 2331748.5
EU funding (EUR): 2239373.5
Participants: 9
Project status: CLOSED

Innovation is at the heart of Europe’s growth strategy. However, Europe lags behind its international competitors in converting investment in Public Research Organisation PRO research into commercial returns via innovation. The solution lies in improving the transfer of technology from PROs to industry but there are many barriers to effective technology transfer, including: Most Technology Transfer Offices (TTOs) in PROs are small, underfunded and under-skilled; a small investor pool and long timescales make it difficult to secure finance and; there is poor understanding between IP creators, exploiters, funders and end-users. To address these barriers, PROGRESS-TT will transfer the expertise of Europe’s leading PROs to those with the greatest potential to grow. We will gather best practice from leading PROs and thought leaders and formulate it into Europe’s most definitive TT tools, methods and insight. We will then begin a programme of knowledge transfer tailored to the audience’s level of ‘readiness’ to grow. This will include: • Training, workshops, boot camps and e-learning delivered to emerging PROs and TT funds to develop their core skills • Intensive coaching and mentoring for high potential PROs to accelerate their TT activity. We will form ‘teams’ comprising experienced TTO performers, industry, funds and high potential PROs to develop capability, capacity, opportunity, desire, and to build a supportive TT environment. • Improving access to finance by bringing established and emerging funds together to share best practice and identify cross-border opportunities We will continuously improve best practice based on our trial activities, in order to create a validated legacy programme to continue supporting PROs across Europe beyond project end. Through this support, we estimate a typical high potential PRO will improve its performance by 500% in the five years following intensive support, delivering at least €6 million to the European economy per PRO supported

Keywords: best practice,commercialisation,public research organisations,knowledge transfer,capacity building,teaming,coaching,training,clustering,legacy
Circularly Polarized Antenna Arrays for Broadband Satellite Data Terminals Using Substrate Integrated Waveguides enhanced with Metamaterials (SIW-SAT-ANTENNAS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-06-16
End date: 2017-06-15
Duration (months): 24.0
Total project cost (EUR): 170121.6
EU funding (EUR): 170121.6
Participants: 1
Project status: CLOSED

There is a currently increasing interest for broadband mobile satellite communications that can fulfil the Digital Agenda 2020 objective for fast Internet everywhere. Furthermore,European regulators have recently agreed to harmonize the spectrum for Earth Stations on Mobile Platforms that will use parts of the Ka-Band (17-30 GHz). Operators such as Inmarsat are planning to launch Ka-Band broadband satellite data services. New antennas and related components are required for the mobile terminals. It is proposed that broadband and miniaturized Circularly Polarized (CP) Antenna Arrays Using Substrate Integrated Waveguides(SIW) enhanced with metamaterials will be developed. SIW is a progressively important technology for millimeter waves and metamaterials (artificially macroscopic structures that mimic materials) have been transforming many wireless system components. Few papers have reported SIW CP antenna arrays and no compact flat antenna designs have yet been published for such applications. Antenna arrays with at least 8x8 elements are expected to satisfy link budget requirements. A synthetic approach is proposed that combines SIW with metamaterials for miniaturization and broadbanding. Moreover, evolutionary algorithms are exploited for efficient array geometry optimization in order to reach the desired broadband performance. Complementary circuit components will also be investigated; waveguide transitions and couplers that affect the size of the feeding network and consequently the array size. The innovative antennas coming out of this project can contribute to a competitive advantage for European industry and have an impact on the adoption of broadband mobile satellite Internet. The IPR potential is significant and offers future research opportunities on antennas for emergent millimeter wave applications. Moreover, the training plan arms the experienced researcher with research management skills that are critical to arrive at a leading independent position.

Keywords: antennas,satellite communications,broadband internet
Novel Materials and Manifacturing Process Enabling Wristed Micro-Instruments: Business Feasibility Of Surgical Applications (MicroInstrmntsBP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Italy
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2015-01-01
End date: 2015-05-31
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

MicroInstrmntsBP aims at planning the best business approach to the commercialization of micro-surgical instruments with the same dexterity of state-of-the-art instruments but smaller in size. The reduction in size allows the instruments to be introduced and used in smaller surgical fields and will open up robotic micro-surgery and endoscopic applications, that are currently beyond the capabilities of state-of-the-art products and have an estimated market size 10x the current 2014 market size for wristed surgical instruments (0.5 Billion USD). Micro-wristed instruments are enabled by a proprietary, integrated design and a proprietary manufacturing process. Medra's design & manufacturing process for 3d micro parts allows parts to mate together with high precision. Current manufacturing technologies are limited in the fabrication of small 3d parts, especially parts for assemblies, by limits on the achievable geometry of the parts and their tolerances. We have overcome such limitations and are able produce very precise small parts in very hard and high yield strength materials. Such an approach allows to counter the weakening of the parts due to the scaling down of the dimensions. 5 month out goals are international IP filings and definition of first viable product based on surgical procedure-specific market size and risk-adjusted business opportunity.

Keywords: micro fabrication technologies,wire edm,polymer fibers,technical fibers,surgical instruments microsurgery
Geographies and Histories of the Ottoman Supernatural Tradition Exploring Magic, the Marvelous, and the Strange in Ottoman Mentalities (GHOST)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Greece
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-03-01
End date: 2024-02-29
Duration (months): 72.0
Total project cost (EUR): 1289737.75
EU funding (EUR): 1289737.75
Participants: 1
Project status: SIGNED

The project aims to explore Ottoman notions and belief systems concerning the supernatural. Its major objectives will be to explore the meaning and content of the perceptions of the “supernatural”, to localize such beliefs in the various Ottoman systems of thought, to analyze the changes that took place and to associate them with emerging or declining layers of culture and specific social groups. The project will address larger debates in recent historiography about the relevance of the “disenchantment” and “enlightenment” paradigms, integrating Ottoman intellectual history into the broader early modern cultural history. The research team, composed of the PI, three post-doctoral fellows, four collaborating researchers, five post-graduate students and a technical assistant, will explore these objectives and produce a web portal (containing crowd-sourced dictionaries and bibliographies, open access papers and other material), three international meetings, monographs and papers, and an annual open-access periodical journal. Specific research modules will study the rationalist trends in Ottoman science, various aspects of the Ottoman occult and magic, and the formation and development of the Ottoman cosmological culture. A monograph will be written by the PI and dwell in: the various conceptions of the supernatural/preternatural and their development, the presence of spirits/jinn in Ottoman world image, theory and practice of Ottoman magic, attitudes toward folklore traditions, saintly miracles, and “marvelous geographies”. Monographs will also be produced by the post-doctoral fellows. The project proposes an innovative approach in many ways, in a subject very much in the frontiers of the field; by exploring the supernatural and the occult in the context of the Ottoman Weltanschauung, the project will address a wider problématique on the Ottoman culture and its place in early modernity, especially as it will focus to the role of different cultural and social layers.

Keywords: preternatural,supernatural,ottoman empire,disenchantment,enlightenment,islamic studies,witchcraft,occult,worldview
Electron Transfer Across Solid/Liquid Interfaces: Elucidating Elementary Processes from Femtoseconds to Seconds (SOLWET)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-08-01
End date: 2024-07-31
Duration (months): 72.0
Total project cost (EUR): 2250000.0
EU funding (EUR): 1594312.5
Participants: 2
Project status: SIGNED

Building fuel cells, electrolyzers or photoelectrochemical cells based on water (photo)electrolysis is extremely challenging. One origin of this challenge is the complexity of the underlying physical chemistry. Most such devices require transfer of electrons between solid(s) and water and thus building the best possible devices requires understanding the link between transient changes in bulk solid electronic structure, interfacial electronic structure and interfacial chemistry. Essentially all existing approaches address only part of this picture: e.g. they only probe electronic structure (optical absorption), or extracted current or provide elemental insight but are insensitive to the presence of hydrogen (x-ray absorption). In SOLWET, I will address this gap using interface-specific optical spectroscopies, in the visible and infrared, to probe interfacial electronic and vibrational transitions and their coupling. By combining these probes with an additional intense laser pulse I will watch (photo)electrolysis of water in real time as it happens. In particular, I will directly probe the coupling of transiently perturbed solid electronic structure to interfacial electronic structure and watch how this perturbation drives water’s oxidation, for a hematite photoanode, or reduction, for a Pt cathode, through the interfacial vibrational response. By describing how these couplings change with solid modification (e.g. an alumina overlayer on hematite) or changes in aqueous solution composition (e.g. changing the pH in contact with Pt) the results of SOLWET will offer the physical insights necessary to build the best possible hematite and Pt containing photoelectrochemical devices. Moreover, because the novel all-optical tools developed in SOLWET are not system-specific, the approach demonstrated in this work will be widely applicable.
In vivo functions of nuclear envelope rupture and antiviral specialization in dendritic cells (DCBIO)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2018-02-01
End date: 2020-01-31
Duration (months): 24.0
Total project cost (EUR): 173076.0
EU funding (EUR): 173076.0
Participants: 1
Project status: CLOSED

Dendritic cells (DCs) function at the interface between innate and adaptive immunity and have a crucial role in the induction of immune responses. The goal of this project is to uncover the in vivo functions of two novel molecular mechanisms that were recently identified in vitro in DCs. DCs are rapidly activated when DNA is exposed to the cytosol, which can occur in viral infections. Recent work has revealed that DNA is also transiently accessible to the cytosol in migrating DCs due to rupture of the nuclear envelope, and is detected by the cytosolic DNA sensor cGAS. In the first aim of this project we will investigate the immune consequences of nuclear envelope rupture in DCs in vivo. The second aim of this project is to investigate antiviral specialization of DC subsets. Viral infection of DCs impairs their immune functions. Unpublished data has revealed that in humans, the CD141+ DC subset is constitutively resistant to a broad range of enveloped viruses. Resistance was associated with the expression of the GTPase, RAB15. We will investigate the function of RAB15 in DC biology in vivo to study the division of antiviral labor among DC subsets.

Keywords: dendritic cells,dna sensor,cgas,nuclear envelope,antiviral response