Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Novel Magnesium alloy for bone tissue engineering manufactured by selective laser melting (MACS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain,Poland
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-02-01
End date: 2026-07-31
Duration (months): 30.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 2
Project status: SIGNED

One important health issue in Europe, especially with the aging of the population, is bone (tissue) fracture (damage) as a result of high-energy impact or trauma, tumor resection, infection or osteo-degenerative diseases. This problem is currently managed with fixation devices and porous scaffolds made of bio-inert and biocompatible alloys (Ti, Co-Cr, steels). However, the large elastic modulus mismatch between these permanent materials and the bone tissue leads to osteoporosis and secondary fractures. Moreover, secondary surgeries are often necessary to remove these permanent implants. To overcome these limitations, temporary implants from biodegradable and biocompatible metals, such as magnesium (Mg) have been attracted a lot of attention. However, Mg suffers from fast corrosion rates in body fluids, which also impairs cell proliferation and just a few Mg alloys, fabricated by conventional techniques (extrusion and powder metallurgy) have been approved for bone tissue therapies so far. These techniques do not allow to control the porosity (pore shape, size and connectivity), which is necessary to ensure appropriate cell proliferation and tissue growth. Hence, the project MACS aims at developing a new generation of Mg alloys suitable to manufacture by selective laser melting porous scaffolds with optimum porosity, mechanical properties, corrosion resistance and biocompatibility to be used for bone tissue engineering. Particular emphasis will be paid to the engineering of surface coatings to ensure the appropriate rates of corrosion and cell proliferation so the biodegradable scaffold will be gradually replaced by the tissue. Porous scaffolds will be designed and manufactured by selective laser melting with the new alloy and engineered with surface coatings. The mechanical properties, corrosion resistance as well as bioactivity for bone tissue regeneration will be determined by means of in vitro tests.

Keywords: magnesium alloys additive manufacturing porous scaffold biocompatibility coating
FLUAR - A novel solution for fluorescence-guided surgery based on augmented reality (FLUAR)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Luxembourg
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-04-01
End date: 2025-03-31
Duration (months): 24.0
Total project cost (EUR): 3514695.0
EU funding (EUR): 2458000.0
Participants: 1
Project status: SIGNED

Fluorescence-guided surgery (FGS) uses near-infrared (NIR) sensors to detect and display fluorescent biomarkers indicating the exact location of tumors. But the current cameras and monitors force surgeons to match the images to the body via subjective comparisons. This long, error-prone process reduces the accuracy, and increases operating times and cost. This is a critical problem in cancer surgery where complete tumor removal is key to prevent recurrence, e.g. a yearly incidence of <0.5 M breast cancer patients requires over 2.8 M surgeries. FLUAR are novel augmented reality (AR) glasses with integrated high-end NIR sensors and computer vision algorithms. They detect and display the fluorescent biomarkers in the surgeons’ direct sight, hence show the tumor margins on the target. FLUAR will increase the surgeons’ accuracy and reduce tumor removal times. This project aims to finalize and validate FLUAR’s technical developments and clinical usability according to end-user requirements.

Keywords: computer vision,medical devices,cancer,surgery,fluorescence guided surgery,fluorescent biomarker,indocyanine green,surgical navigation,artificial intelligence,3d visualization,machine learning,augmented reality,mixed reality,extended reality,human computer interaction,assistive technologies,wearable technology,hologram,near infrared imaging
MOBILISING AND PROFESSIONALIZING TRANSNATIONALLY THE HEALTH NCP COMMUNITY, SKILLS AND SERVICES (HNN 3.0)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Staying Healthy in a rapidly changing society
Action type: Coordination and support actions
Countries involved: Italy,Portugal,Belgium,Cyprus,Germany,Greece,Estonia,Poland,Ireland,Spain,Iceland,France,Czechia,Lithuania,United Kingdom,Latvia,Switzerland
Call: Mobilising a network of National Contact Points (NCPs) for the Health Cluster (HORIZON-HLTH-2021-STAYHLTH-01, 2021)
Start date: 2022-06-01
End date: 2029-05-31
Duration (months): 84.0
Total project cost (EUR): 2886727.5
EU funding (EUR): 2886726.75
Participants: 17
Project status: SIGNED

The objective of HNN3.0 is to facilitate the transnational co-operation between National Contact Points (NCPs) for the CL1 in order to achieve a consistent and harmonized level of NCP support. Action will last 7 years to bridge NCPs to next programme. Next to developing support for the facilitation of daily challenges for all NCPs, we put the focus on lowering the entry barriers for new NCPs and offer particular support services for Widening Country NCPs and applicants. The role of the NCP has become progressively more visible and consistent alongside the 7th and 8th Framework Programmes. Moreover, since more than a decade, the EC is providing funding to develop joint actions that helps NCPs getting organized in international networks, thus contributing to best achieve its R&I and outreach objectives. NCPs are again an essential component for the brand new programme Horizon Europe?s implementation. They can be envisaged as the ?ambassadors? of the world?s greatest collaborative research programme in the Member States (MS), Associated Countries (AC) and Third Countries (TC). By spreading awareness, giving specialist advice, and providing on-the-ground guidance, they must ensure that the new programme becomes known and readily accessible to all potential applicants, irrespective of sector or discipline. HNN3.0) Health NCP Net has been made to give continuity to the previous network set up under H2020 and to maintain its identity and recognizability within both the NCP community and the wider applicants community, and because CL1 is sometimes referred to only as ?Health?, for shortening and simplification reasons. Four major target groups are addressed in the 7 years project activities: i.) appointed CL1 NCPs, ii.) their clients/applicants, iii.) other NCPs and important stakeholders, and iv.) the European Commission/HaDEA.

Keywords: national contact points,transnational cooperation,capacity building,matchmaking
An Atlas of Organisation of Lipids in Extracellular Vesicles To Navigate Their Roles in Cancer Metastasis (CanExCell)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Materials Engineering
Panel description: Advanced materials development: performance enhancement, modelling, large -scale preparation, modification, tailoring, optimisation, novel  and combined use of materials, etc.
Countries involved: Sweden
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 2499818.0
EU funding (EUR): 2499818.0
Participants: 1
Project status: SIGNED

It is estimated that up to 90% of cancer deaths are caused not by the primary cancer but after it has metastasised, i.e. spread to other organs in the body, and it is well known that the locations of metastasised tumours are specific to the location of the primary cancer. Communication and transfer of material between cells is a fundamental process in cell biology, for which nature uses extracellular vesicles (EVs). These nanometre-sized vesicles are excreted by cells and contain signature combinations of membrane lipids, nucleic acids, proteins and surface markers. EVs excreted by cancer cells play an important role in communication between tumours and distant organs where metastases can take hold. While more is now understood about the role of EV nucleic acids, proteins and surface markers in these processes, the role of EV lipid composition, and especially the role of asymmetric lipid distribution across the membrane, remains overlooked. I address this fundamental research question by developing an interdisciplinary approach for mapping the asymmetric lipid composition of EVs with varying pro-metastatic nature from a library of cancer cell lines. I will create an atlas of asymmetric lipid compositions of EVs excreted by cancer cell lines, including quantitative data on the asymmetric lipid distribution between the inner and outer membrane leaflets (asymmetric lipid distribution). To study the role of EV lipid composition on selective uptake in cells from the original tumour and pre-metastatic environment, I will apply neutron scattering and super-resolution microscopy techniques. Taken together, the atlas of cancer-derived EV asymmetric lipid compositions that I will develop represents a significant advance to the state of the art, and a ground-breaking combination of cell biology with engineering-based tools for chemical and biophysical in-depth characterisation of complex, asymmetric membranes.

Keywords: lipid self assembly,vesicles,extracellular vesicles,lipidomics,neutron scattering,neutron reflectometry,lipid phase behaviour,liposomal formulations,cancer
ORBital-based electronIcS (ORBIS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,Germany,France,Netherlands,Portugal,Sweden,Switzerland,Estonia
Call: MSCA Doctoral Networks 2024 (HORIZON-MSCA-2024-DN-01, 2024)
Start date: 2026-02-01
End date: 2030-01-31
Duration (months): 48.0
Total project cost (EUR): 4904112.45
EU funding (EUR): 4513458.24
Participants: 24
Project status: SIGNED

Orbitronics, an emerging field that focuses on the study and manipulation of the electron's orbital angular momentum (OAM), provides a challenging and innovative framework to train doctoral candidates (DCs) with excellent career prospects in academia, industry and beyond. In this promising area, ORBIS proposes a multidisciplinary network composed of 12 universities, 4 research centres and 8 companies, which will provide DCs with state-of-the-art training combining fundamental and applied Orbitronics. The overarching scientific and technological goal of ORBIS is to understand the mechanisms behind orbital effects, to find emerging materials enabling efficient generation, transport and control of OAM, and to build devices based on these phenomena, including enhanced THz emitters, magnetic random-access memory and beyond-CMOS logic. These orbital-based technologies will be cheap, low power, scalable and environmentally sustainable, thus having the potential to bring about revolutionary advances in microelectronics with enormous societal impact. ORBIS will train 16 DCs through research in the physics of orbital currents, orbital torques, 2D and low-symmetry materials, orbital phenomena in the time domain, magnetic excitations, and topology. The DCs will apply cutting-edge methodologies in new materials, device nanofabrication and characterization, ultrafast spectroscopies, and theoretical calculations and models. Interdisciplinary secondments will enable the exposure of each DC to academia and industry for a total of 6 months. ORBIS will organise 5 focus topic workshops from basic research to applications and open them to researchers outside the consortium. It will also organize 5 transferable skills workshops that will increase the employability of the DCs. Ultimately, the project’s impact will stem from training the next-generation workforce essential for Europe's growing technology sector and vital for strengthening its industrial competitiveness.

Keywords: orbitronics,spin orbit torques,spin hall effect,rasbha effect,edelstein effect,mram,spin based logic,terahertz emission,magnonics
Identification of novel viral entry factors and development of antiviral approaches (DEFENDER)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Germany,Switzerland,United Kingdom,France
Call: Pandemic preparedness and response: Host-pathogen interactions of infectious diseases with epidemic potential (HORIZON-HLTH-2024-DISEASE-08, 2024)
Start date: 2025-01-01
End date: 2029-12-31
Duration (months): 60.0
Total project cost (EUR): 7949326.25
EU funding (EUR): 7949326.25
Participants: 12
Project status: SIGNED

DEFENDER will address the need for innovative intervention strategies against viruses with epidemic potential, by adopting a comprehensive and integrative platform approach. DEFENDER’s revolutionary Research and Innovation pipeline will focus on preventing virus entry through a host-directed bottom-up approach based on functional genetics in parallel to a top-down virus glycoprotein-centered approach. We will identify novel host dependency and restriction factors, including receptors and proteins involved in viral attachment and binding, endosomal uptake and virus genome uncoating, as targets for antiviral therapy. In parallel, we will use recombinant viral glycoproteins to identify broadly neutralizing nanobodies and novel epitopes for the AI-based design of next generation immunogens and the improvement of therapeutic antibodies. The host bottom-up functional genetic approach will be applied to Nipah, Lassa, Zika, Dengue, Yellow fever, and Chikungunya viruses. Host factors will be identified using a unique arrayed CRISPR perturbation platform, combined with advanced statistical and machine learning approaches and mathematical modelling, mechanistic experiments, and cutting-edge imaging techniques. In parallel, the virus top-down glycoprotein-centered approach will lead to the identification and structural characterization of broadly neutralizing nanobodies targeting conserved epitopes of the glycoproteins of Nipah and Lassa viruses in pre-fusion conformation. DEFENDER will deliver innovative antiviral candidates that induce target degradation, next generation immunogens, and a novel concept to improve the activity of therapeutic antibodies, with proof-of-concept preclinical evaluation in mice. It will define the most vulnerable virus-host interactions, to deliver a robust development pipeline for novel antivirals, therapeutic antibodies, and immunogens and increase antiviral options against a wide range of priority (re-) emerging viruses.

Keywords: virus entry,virus host interactions,functional genetics,virus glycoproteins,neutralizing nanobodies,immunogens,therapeutic antibodies,antiviral options
MindGuide – Improving the Mental Health of Adolescents with digitized screening process and feedback loop optimisation (MindGuide)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Slovenia
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-03-31
Duration (months): 9.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

There is a significant societal challenge of high levels of mental illness in adolescents (aged 13-20). As many as 70% of young people with mental health conditions do not receive adequate professional help. Negative stigmas associated with being mentally ill; overburdened healthcare systems with long waiting times and a traditional approach that is largely un-digitized are some of the largest barriers to adolescents accessing help. Zamax founder and CEO, Dr. Lina Klanšek, is a specialist in adolescent psychiatry. She is acutely aware of the obstacles that prevent young people from accessing mental health support, and is using her knowledge in the field to develop MindGuide. MindGuide is a unique interactive platform for youth mental health. We are developing a chatbot to detect likely mental health conditions in the user. Based on these results, MindGuide will offer a clinical treatment suggestion, providing connections to access these. Following the treatment process, MindGuide will conduct a follow-up with the user. Within this, it discovers whether the suggested treatments were engaged with, if they were successful, and if not, why. The data collected in this stage will create a feedback loop to inform and optimise the entire platform, particularly the screening process and the treatments suggested. Leveraging the proposed BES support, the objectives of the project include: • Developing and incorporating feedback loop • Further understanding and developing the market opportunity in the context of latest conditions and drivers and alongside final technical solution development. • Refining a detailed and rigorously reviewed business plan. • Clearly defining the product offer and most effective routes for dissemination to target market/s. • Establishing clear plans for scaling the business opportunity and operations

Keywords: mental health,adolescent psychiatry,health screening,personalised support
Biodiversity change across time and space in the Anthropocene: Leveraging metacommunity modelling, land-use change, and open data to achieve deeper understanding (MetaChange)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany,United Kingdom
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 2439071.0
EU funding (EUR): 2439071.0
Participants: 2
Project status: SIGNED

Despite connections between metacommunity level processes that maintain biodiversity and anthropogenic pressures that erode those processes, these have not been well integrated. I propose a multifaceted approach that (1) builds on metacommunity theory to develop expectations for the influence of anthropogenic drivers on scale-explicit biodiversity change; (2) uses this theory to develop an analytical pipeline to disentangle local and landscape factors driving this change; (3) use the derived results to develop scale-explicit projections of future biodiversity change that can aide biodiversity policy decisions. With theoretical expectations and analytical procedures in hand, we will synthesize biodiversity change across scales, and the relative influence of local versus landscape-level drivers on those changes. We will apply our analytical pipeline to the largest compilation of metacommunity time series to provide a comprehensive analysis of biodiversity change. We will complement this with a data collection campaign to ‘resurvey’ zooplankton metacommunities from ponds that had been surveyed 10-50 years previously, but which have experienced different levels of background ‘change’ (e.g., loss of nearby habitat). We will also compile a database to explore the potential influence of habitat restoration via local and landscape processes, and its influence on scale-explicit biodiversity change. We will analyse these synthetic datasets together with geospatial driver data using our novel analytical pipeline. Finally, we will develop a unique pipeline integrating metacomunity theory with our synthetic results and machine learning to develop projections of biodiversity change in the face of scenarios of anthropogenic change. With the information gained, we will contribute not only to a better understanding of the most important feature of life on this planet—its biodiversity—but by developing this understanding, we can provide an avenue to mitigate the changes.

Keywords: metacommunity theory,synthesis,restoration,land use,habitat loss,dispersal limitation,resurvey,pond,wetland,forest,grassland
Pre-Hellenic Loanwords in Greek: Lexicon of the Substrate Analysed (PHILOGLOSSA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-01
End date: 2025-08-31
Duration (months): 26.0
Total project cost (EUR): 214934.4
EU funding (EUR): 214934.4
Participants: 1
Project status: SIGNED

PHILOGLOSSA aims to provide a critical reassessment and analysis of the loanwords borrowed into the Ancient Greek language of from the prehistoric languages early Greek speakers encountered in the Bronze Age Aegean. These 'Pre-Hellenic' (or 'Pre-Greek') loanwords have long been recognised to constitute a significant layer in the Greek lexicon, the earliest of which are already present in Mycenaean Greek attested by Linear B documents. Despite the phenomenon being well known, the historical origins and linguistic interpretation of these loanwords have remained controversial, and attempts to explain them as from a single source (as per the interpretational framework of the latest, controversial Etymological Dictionary of Greek [2010, Leiden] by Robert Beekes) has been fraught with methodological problems. PHILOGLOSSA will build an open-access linguistic database to facilitate a fresh analysis of the material that will be conducted as the main research activities of the project. As new archaeogenetic studies have provided new evidence strongly suggesting intensive and sustained social and cultural interaction between the incoming early Greek speakers and the earlier inhabitants of the Aegean, it is of crucial importance to re-evaluate the linguistic evidence for these exchanges preserved in the Ancient Greek language. As such the results of PHILOGLOSSA will be of interest not only to those interested in the history of the Greek language, but also to Indo-European comparative linguists, Aegean prehistorians, archaeologists, and geneticists more broadly.

Keywords: ancient greek linguistics,loanword studies,indo european studies,linguistic and cultural prehistory,lexicography