Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Econometric analyses and indicators on Research, Excellence and Impact of Research and Innovation (INNOVA MEASURE IV)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Theme: Innovative societies
Action type: Coordination and support actions
Countries involved: Belgium
Call: Development of composite indicators on R&I performance and econometric analysis (H2020-IBA-SC6-INNOVAIV-2019, 2019)
Start date: 2019-05-01
End date: 2020-10-31
Duration (months): 18.0
Total project cost (EUR): 400000.0
EU funding (EUR): 400000.0
Participants: 1
Project status: CLOSED

The INNOVA MEASURE IV project continues the research activity carried out by the JRC in support of the work on better evidence for policy-making by the Directorate-General for Research & Innovation. It builds on the outcomes and capacities developed within the framework of the INNOVA MEASURE I-III projects. It focuses on three interrelated research streams, complemented by adequate dissemination: (1) The update and -as necessary- the refinement of the methodologies used for composite indicators measuring R&I performance. This includes the development, enhancement, and production of composite indicators on R&I (including the Innovation Output Indicator and the adjusted Research Excellence Indicator); it also includes a specific angle in support of the statistical work around the European Innovation Scoreboard, led by DG RTD and GROW; (2) Improving the availability of evidence on startup and scale-up of innovative firms, with a focus on “the makers of robots”, or companies in the field of artificial intelligence and robotics; (3) Support to analyses around R&D investments from abroad. This work stream studies European countries and regions as part of a global network of foreign investments in R&I, with the ultimate aim to identify the impact of foreign corporate knowledge ties on local innovation performance. It includes statistical econometric analyses on the internationalization of R&D and on the complex associations between innovation, growth, inequality and competitiveness.

Keywords: indicators,composite indicators,research and innovation,knowledge intensive interactions,foreign direct investment,mergers and acquisitions
Liquid Foam Therapy (LIFT) for Acute Respiratory Distress Syndrome (ARDS) (LIFT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Israel
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-10-01
End date: 2020-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Acute Respiratory Distress Syndrome (ARDS) is an inflammatory lung condition caused e.g. by sepsis, pneumonia and head or chest injury, affecting annually 133,000 people in Europe and 255,000 in the US. ARDS is characterized by the depletion of the lungs’ inner liquid coating (pulmonary surfactant), which reduces surface tension forces and allows the lungs to expand. Patients span across all age groups and lay anesthetized in the intensive care unit with mortality rates at 40%. Although surfactant replacement therapy (SRT) is a life-saving procedure in newborn neonates, current administration methods to treat adults and even children remain inadequate. Endotracheal surfactant liquid instillations used in babies fail in larger lungs: liquid drains into pools, drowning these lung regions while leaving others untreated. Meanwhile, inhalation aerosols can only deliver small doses (<1ml/hr for nebulizers), far from the required ~100ml of surfactant. To overcome such hurdles, we advocate using liquid foam as a surfactant carrier to the lungs, i.e. LIquid Foam Therapy (LIFT). Foam is weakly affected by gravity, distributes homogeneously within lungs and in abundance. LIFT brings a paradigm shift in SRT, and more broadly, in the field of therapeutic pulmonary delivery. Our team bridges expertise in clinical ARDS treatment in neonates, pulmonary medicine, biomedical engineering and business. Together, we have demonstrated the feasibility of our patent pending technology, both in vitro in 3D printed and microfabricated airway models, and ex vivo in excised pig lungs using fluoroscopy. In this PoC, we will optimize the foam formulation, design and construct a delivery device, and run pre-clinical in vivo animal experiments. LIFT has the potential to extend far beyond ARDS treatment and be leveraged for other lung therapies, such as stem cell delivery directly to the lungs to treat Idiopathic Pulmonary Fibrosis (IPF) and Chronic Obstructive Pulmonary Disease (COPD).

Keywords: lungs,respiratory distress syndrome,pulmonary therapy,biomedical engineering,medical devices
Correlated frontiers of many-body quantum mathematics and condensed matter physics (CORFRONMAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: France
Call: ERC Starting Grant (ERC-2017-STG, 2017)
Start date: 2018-01-01
End date: 2023-12-31
Duration (months): 72.0
Total project cost (EUR): 1056664.0
EU funding (EUR): 1056664.0
Participants: 1
Project status: SIGNED

One of the main challenges in condensed matter physics is to understand strongly correlated quantum systems. Our purpose is to approach this issue from the point of view of rigorous mathematical analysis. The goals are twofold: develop a mathematical framework applicable to physically relevant scenarii, take inspiration from the physics to introduce new topics in mathematics. The scope of the proposal thus goes from physically oriented questions (theoretical description and modelization of physical systems) to analytical ones (rigorous derivation and analysis of reduced models) in several cases where strong correlations play the key role. In a first part, we aim at developing mathematical methods of general applicability to go beyond mean-field theory in different contexts. Our long-term goal is to forge new tools to attack important open problems in the field. Particular emphasis will be put on the structural properties of large quantum states as a general tool. A second part is concerned with so-called fractional quantum Hall states, host of the fractional quantum Hall effect. Despite the appealing structure of their built-in correlations, their mathematical study is in its infancy. They however constitute an excellent testing ground to develop ideas of possible wider applicability. In particular, we introduce and study a new class of many-body variational problems. In the third part we discuss so-called anyons, exotic quasi-particles thought to emerge as excitations of highly-correlated quantum systems. Their modelization gives rise to rather unusual, strongly interacting, many-body Hamiltonians with a topological content. Mathematical analysis will help us shed light on those, clarifying the characteristic properties that could ultimately be experimentally tested.

Keywords: calculus of variations,partial differential equations,spectral theory,schr dinger operators,bose einstein condensates,mott insulators,fractional quantum hall effect,fractional statistics
BIO-PHOTONIC IMAGING OF THE INFANT BRAIN, THE MISSING LINK BETWEEN THE CELLULAR BRAIN DAMAGE AND THE NEUROVASCULAR UNIT DURING ACUTE ILLNESS (TinyBrains)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Partnership: Photonics (cPPP)
Countries involved: Spain,Ireland,France
Call: Disruptive photonics technologies (H2020-ICT-2020-2, 2020)
Start date: 2021-01-01
End date: 2024-12-31
Duration (months): 48.0
Total project cost (EUR): 3773357.5
EU funding (EUR): 3773357.5
Participants: 7
Project status: SIGNED

The brain of the newborn is very different from the adult posing a major problem in assessing the origins of its injuries and in developing therapeutics. This is further complicated when the newborn was born prematurely or its in-utero development has been compromised. In these situations, their interplay between contributing factors become complex to understand with current tools since they are technically and ethically difficult to employ widely. TinyBrains will develop a neuro-imager and focus on congenital heart-defects (CHD). CHD is the most prevalent congenital malformation with about a million births worldwide annually. Advances in surgical techniques and perioperative management have dramatically reduced mortality rates with more than 85% surviving to adulthood. However, significant neurodevelopmental problems are observed in about 50% due to brain injury. It being so prevalent and also having accepted accionable points in its care and therapy, TinyBrains chose CHD as its target to provide a research platform to improve the understanding of the cellular origin of the brain injury by enabling the assessment of the link between energy demand and oxygen supply. To so, we will combine advanced biophotonics technologies and electroencephalography into a disruptive research tool enabling research into new brain-oriented therapies and management strategies. TinyBrains will measure cerebral hemodynamics, oxygen metabolism and electrophysiology simultaneously. In vivo imaging in three-dimensions, i.e. tomography, will greatly increase the brain specificity and penetration as well as, for the first time, providing spatial resolution to this class of measurements. This plethora of information will enable us to carry out pre-clinical animal and clinical studies in infants with and without CHD to gain a peek at the cellular origins of brain injury. By bringing together academia, clinics and industry, TinyBrains further seeks to create the path for exploitation.

Keywords: neuro imaging,biophotonics,near infrared spectroscopy,pediatrics,congenital heart defects,brain,biomedical optics,diffuse optics,neurosciences,cerebral blood flow
Bioprinting on-chip microphysiological models of humanized kidney tubulointerstitium (BIRDIE)

Framework: Horizon 2020 — Excellent Science
Programme: Future and Emerging Technologies (FET)
Theme: EIC Pathfinder
Destination: Novel ideas for radically new technologies
Action type: Research and Innovation actions
Countries involved: Germany,Sweden,France,France,Netherlands
Call: FET-Open Challenging Current Thinking (H2020-FETOPEN-2018-2019-2020-01, 2020)
Start date: 2021-03-01
End date: 2025-02-28
Duration (months): 48.0
Total project cost (EUR): 2999425.0
EU funding (EUR): 2999425.0
Participants: 6
Project status: SIGNED

Eight hundred and fifty million people worldwide are currently affected by chronic kidney disease (CKD), which is also the 11th leading cause of mortality worldwide. CKD can occur from a multitude of causes including diabetes and high-blood pressure. Moreover, recent clinical and experimental studies have shown that CKD is closely interconnected with acute kidney injury (AKI) as well. Currently available in vitro models show limited relevance to study AKI, especially drug- and virus- induced AKI, due to the poor functionality and relevance compared to a diseased human tissue. BIRDIE aims at developing three-dimensional (3D) in vitro human renal tubulointerstitium (TI) models to enable viral infection and nephrotoxicity studies while creating a robust platform to address other diseases and treatment innovations in the future. Two enabling technologies, bioprinting and organ-on-chip, will be combined to build a microphysiological relevant TI model. Primary human cells and induced pluripotent stem cells will be used to generate kidney models, and combined with the aforementioned techniques model envisioning a reliable screening platform for future patient specific therapies. Our ambition is to create a new 3D renal in vitro model allowing an unprecedented degree of mimicry and function compared to a human kidney. While developing the model focusing on the applications mentioned before, our goal is to make it broadly applicable to the multitude of kidney-related diseases.

Keywords: bioprinting,organ on chip,microphysiological in vitro models,bk polyomavirus,drug induced toxicity,human cells,organoids
Integrin specificity in rigidity sensitive proliferation, activation and directional migration of endothelial cells (ISPADMEC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-09-01
End date: 2018-06-26
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Cells have the extraordinary ability to regulate their morphology, functions and fate to minimal changes in the extracelullar microenvironment. Through multi-protein, cell-matrix adhesions they are able to recognize and respond not only to the chemical diversity of the extracellular matrix (ECM), but also to its physical and topographical features. Mechanical and structural cues encoded in the ECM have an essential role in healthy tissue function where contractility, spreading and proliferation are intricately regulated by cell-cell and cell-matrix adhesion and tension. Unsurprisingly, abnormal ECM mechanics are directly associated with disease and tissue malformation (atherosclerosis, wound healing and tumor formation). Understanding the mechanisms cells use to sense and transduce mechanical signals, as well as the contribution of key players in the process is a pressing, unmet challenge. To achieve this goal, I here propose the development of an in vitro strategy that allows precise regulation of both biochemical and mechanical parameters in order to isolate their contribution on fundamental endothelial cell (EC) functions. The proposed work will exploit advances in materials science and nanotechnology to modulate with high precision the presentation of highly selective integrin ligands at the nanometer and micrometer length scales, on substrates with tunable viscoelasticity and mechanics. The anticipated effects of integrin engagement and substrate mechanics on ECs will shed light on how the microenvironment affects their proliferation, activation and directional migration, and help correlate these finding with pathological scenarios where blood vessel mechanics and EC integrin expression are deregulated. In summary, the proposed interdisciplinary approach will contribute both advanced tools to study cells in vitro and crucial answers for specific questions relating to EC biology.

Keywords: mecanotransduction,extracellular matrix,integrins,hydrogels,micro,nanopatterning
Modulation of juvenile hormone signaling by receptor phosphorylation (JHSIGNAL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Czechia
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 154720.8
EU funding (EUR): 154720.8
Participants: 1
Project status: CLOSED

Juvenile hormones (JHs) are lipophilic signals of vital importance to insects and related arthropods, representing the most successful group of animals on our planet. Among species relying on regulation by JH are beneficial pollinators and crustaceans, as well as agricultural pests and disease vectors. Manipulation of JH signaling is a good target for insecticide control. Therefore, knowledge of JH signaling is important both for fundamental science and for practical use. The intracellular JH receptor has been identified, largely through work in the host laboratory, but its action is still poorly understood. Current evidence suggests that activity of this JH receptor is modulated by JH-induced phosphorylation. The objective of this proposal is to identify the phosphorylation target sites and to determine their significance for the JH receptor function. To achieve this goal, the status of amino acid residues potentially phosphorylated in response to JH will be determined using mass spectrometry of the JH receptor protein expressed in insect cell lines. The key residues will be mutated either to prevent phosphorylation or to mimic a constitutively phosphorylated state, and the mutant receptors will be examined for capacity to bind JH, induce JH-response genes, and sustain normal insect development in vivo. The approach thus ranges from protein biochemistry through cell-based assays to developmental genetics employing the Drosophila model. The goals are achievable through the combined expertise of the Applicant, extensively trained in protein chemistry and molecular biology at the top-ranking US universities, and the host laboratory of Dr. Marek Jindra, who is among the leaders in insect developmental endocrinology and JH research in particular. This project will enable the Applicant to fully expand her potential and learn insect developmental genetics while permanently integrating to European science.

Keywords: lipophilic hormones,juvenile hormone,intracellular hormone receptors,bhlh pas proteins,transcription factors,protein phosphorylation,insects,development,drosophila,tribolium
Assessing cellular compartmentation of brain lactate using diffusion MR spectroscopy in vivo (LactaDiff)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: France
Call: ERC Consolidator Grant (ERC-2018-COG, 2018)
Start date: 2019-05-01
End date: 2025-10-31
Duration (months): 78.0
Total project cost (EUR): 1999868.0
EU funding (EUR): 1999868.0
Participants: 1
Project status: SIGNED

The idea has emerged that compartmentation of brain lactate, i.e. its distribution between different cell types and the extracellular space, plays a critical role in neurotransmission and brain plasticity. Dysregulations of lactate metabolism have also been reported in neurodegenerative diseases such as Alzheimer's disease. However, these notions remain challenged, and even fundamental mechanisms such as the astrocyte-to-neuron lactate shuttle, whereby astrocytes are supposed to export lactate to neurons to sustain neuronal energy needs, are still fiercely debated. This is largely due the lack of tools to evaluate cell-specific compartmentation of lactate in the living brain, in particular in Humans. In this project, we will develop new nuclear magnetic resonance spectroscopy techniques to non-invasively measure lactate diffusion, including in cortical regions. We will then take advantage of the unique ability of these methods to differentiate between metabolites diffusing in different environments, based on diffusion properties imposed by the microstructure, to quantify lactate in the extracellular space and, most importantly, in neurons and astrocytes. After validation in rodent models, these methods will be transposed on a clinical MRI system at ultra-high magnetic field, to gain unprecedented access to lactate compartmentation in the Human brain and its modifications during brain activity, plasticity, and in Alzheimer's disease. This will open a new research field for magnetic resonance spectroscopy in vivo.

Keywords: magnetic resonance spectroscopy,novel nmr sequences,diffusion,diffusion modeling,numerical simulations,lactate,brain metabolites,astrocyte,neuron,lactate shuttle,biomarkers,alzheimer
EXTREME LOADING ANALYSIS OF PETROCHEMICAL PLANTS AND DESIGN OF METAMATERIAL-BASED SHIELDS FOR ENHANCED RESILIENCE (XP-RESILIENCE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Italy,Italy,Austria,Germany,Italy,Greece,Poland,Slovenia,Poland,Switzerland,France,United Kingdom,Luxembourg
Call: Innovative Training Networks (H2020-MSCA-ITN-2016, 2016)
Start date: 2016-09-01
End date: 2020-08-31
Duration (months): 48.0
Total project cost (EUR): 3393811.98
EU funding (EUR): 3393811.98
Participants: 15
Project status: CLOSED

The tremendous impact of natural hazards, such as earthquakes, tsunamis, flooding, etc, which triggered technological accidents, referred to as natural-technological (NaTech) events, was demonstrated by: i) the recent Tohoku earthquake and the following Fukushima disaster in 2011; ii) the UK’s 2015 winter floods which topped £5bn, with thousands of families and businesses that faced financial problems because of inadequate or non-existent insurance. The NaTech problem is quite relevant as up to 10% of industrial accidents, involving the release of Chemical, Biological, Radiological, Nuclear and high-yield Explosives (CBRNE) substances, were triggered by natural hazards. To implement and support the Seveso II Directive 2012/18/EU which regulates the control of major accident hazards involving dangerous substances, XP-RESILIENCE intends to establish a network of individual research projects working towards Advanced Modelling and Protection –via metamaterial-based isolators/layouts- of Complex Engineering Systems for Disaster Reduction and Resilient Communities. In fact, today there is a stronger need than ever to grow researchers that combine a robust academic foundation in reliability/resilience with practical experiences, technological expertise with awareness of the socio-economical context and conviction to furthering research with an entrepreneurial spirit. Hence, the objective of XP-RESILIENCE is to offer innovative research training ground as well as attractive career development and knowledge exchange opportunities for Early Stage Researchers (ESRs) through cross-border and cross-sector mobility for future growth in Europe. XP-RESILIENCE is an inter/multi-disciplinary and intersectoral programme as it includes seven academic partners, one Institute of Applied Science and seven private companies from ten different European countries.

Keywords: risk based framework,special risk facilities,community disaster resilience,metamaterial based shields,second generation of en eurocodes