Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Persistent Personal Data Vaults Empowering a Secure and Privacy Preserving Data Storage, Analysis, Sharing and Monetisation Platform (DataVaults)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Innovation actions
Countries involved: Austria,Germany,Spain,Italy,Italy,Spain,Spain,Ireland,Italy,Germany,Cyprus,Greece,Greece,Belgium,Belgium,Greece,Denmark
Call: Supporting the emergence of data markets and the data economy (H2020-ICT-2019-2, 2019)
Start date: 2020-01-01
End date: 2023-04-30
Duration (months): 40.0
Total project cost (EUR): 7664755.0
EU funding (EUR): 5999995.0
Participants: 19
Project status: SIGNED

A strong data economy is emerging in Europe, where both large companies and SMEs acknowledge the fundamental value of Big Data to cause disruptive change in markets and business models . Nevertheless, the growth of the data economy is hampered by the lack of trusted, secure and ethical-driven personal data platforms and privacy-aware analytics methods capable of, on the one hand, securing the sharing of personal data and proprietary/commercial/industrial data and, on the other hand, of strictly and fairly defining how value can be captured, produced, released and cashed out for the benefit of all the stakeholders involved. Addressing this kind of concerns on privacy, ethics and IPR ownership over the DataVaults value chain is one of the cornerstones of the project. Its goal to set, sustain and mobilize an ever-growing ecosystem for personal data and insights sharing and for enhanced collaboration between stakeholders (data owners and data seekers) relies exactly on DataVaults personal data platform’s extra functionalities and methods for retaining data ownership, safeguarding security and privacy, notifying individuals of their risk exposure, as well as on securing value flow based on smart contract. DataVaults aims to deliver a framework and a platform that has personal data, coming from diverse sources in its centre and that defines secure, trusted and privacy preserving mechanisms allowing individuals to take ownership and control of their data and share them at will, through flexible data sharing and fair compensation schemes with other entities (companies or not). The overall approach will rejuvenate the personal data value chain, which could from now on be seen as a multi-sided and multi-tier ecosystem governed and regulated by smart contracts which safeguard personal data ownership, privacy and usage and attributes value to the ones who produce it.

Keywords: data vault,data platform,personal data,data protection,security,personal data business model,fair remuneration,data control,data ownership,data brokerage
Advanced material for the regeneration of joints in veterinary medicine (VETBIOMAT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Nanotechnologies
Action type: SME instrument
Countries involved: Spain
Call: Accelerating the uptake of nanotechnologies, advanced materials or advanced manufacturing and processing technologies by SMEs (H2020-SMEINST-1-2014, 2014)
Start date: 2015-02-01
End date: 2015-07-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The main objective of VetBiomat is to undertake a technical and market feasibility study on an innovative regenerative medicine treatment for osteoarthritis (OA) in horses and dogs based on a new advanced material, HR007. The use of this material is expected to significantly increase treatment efficiency over currently marketed products and address the unmet need of achieving a cure for this disease in horses and dogs. Osteoarthritis, a progressive deterioration of the joint cartilage, is a major economic problem in veterinary medicine. Currently, there is no cure for OA, and therapies available rely on reducing symptoms (corticosteroids, NSAIDs, and analgesics) or on the administration of glycosaminoglycans by different routes. No sound scientific evidence of efficacy for most glycosaminoglycans based commercial treatments has yet been obtained, especially when administered orally, nutraceuticals, which actually have the largest market share. Therefore, the market potential for a new efficacious, complex, and regenerative intra-articular product of non-bovine origin is very large. ArtinVet Innovative Therapies, S.L., a new SME specialized in veterinary regenerative medicine, has a novel and unique multiple GAGs rich material of natural origin, HR007, for inclusion in new regenerative medicine based products for veterinary medicine. This advanced material has shown in vitro superior qualities to any other tested products in promoting cartilage regeneration and chondrocytes and mesenchymal cells migration. HR007 production has been standardized and industrialized. Successful completion of Phase 1 of VetBiomat will yield a robust business plan for a much larger project that will seek funding under Phase 2 of the SEM Instrument, when clinical studies and product authorization procedures will be accomplished. Successful accomplishment of phases 1 and 2 will be essential for accelerating the growth of the SME ArtinVet and its international market positioning.

Keywords: veterinary regenerative medicine,cartilage regeneration,joint diseases,osteoarthritis,glycosaminoglycans,hyaluronic acid,heparin,chondroitin,ketaran,dermatan or heparan sulfate
Automatic Hydraulic Jack with improved capacity, safety and efficiency for agricultural implements (Novel Jack)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Theme: Sustainable agriculture and forestry
Action type: SME instrument
Countries involved: Italy
Call: Stimulating the innovation potential of SMEs for sustainable and competitive agriculture, forestry, agri-food and bio-based sectors (H2020-SMEINST-1-2016-2017, 2017)
Start date: 2017-12-01
End date: 2018-03-31
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Following comprehensive research and consultations with the actual users of jacks in the agricultural sector, the health and safety of the operators relating to physical, repetitive manual jack activities and the potential for lost time and injuries was a major concern. Statistics show that 49% of critical injuries in agriculture are a direct result of being crushed under a tractor or being crushed between a hydraulically mounted machine and vehicle. The removal of manual operations would be an obvious benefit to both employers and employees within the agricultural sector. Simol is an award winning European leading manufacturer of support feet with over 50 years’ experience in the production of supplies for the agricultural sector. We aim to respond to these concerns by producing a simpler, quicker and less labour intensive alternative to the current state of the art, Novel Jack. Novel Jack is a fully automatic hydraulic jack with increased capacity and minimum encumbrance unlike current state of the art. It is also ISOBUS compliant, ensuring that it will be compactable with implements from different brands thus making it a universal solution. Our innovation is 40% cheaper than current solutions and has 64% more lifting capacity with the same functionalities. Novel Jack will result in a 90% reduction in jack related accidents and 80% of jack related downtime of agricultural implements. Novel Jack currently stands at a TRL6, with a first real scale prototype having been developed by our internal team of experts and lab tested. The next steps are to optimise our initial designs, as well as test it in real world conditions before commercialisation. The commercialisation of Novel Jack will consolidate Simol’s position as a global leader in the manufacture and distribution of jacks in the agricultural sector.

Keywords: hydraulic jack,safety,agricultural machinery,lifting capacity
Programming with Big Code (AutoCode)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-05-01
End date: 2018-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Software synthesis aims to automate the creation of software by generating parts of software from a higher-level description. Until recently it was believed to be impossible to practically synthesize software beyond very small fragments. However, synthesis based on learning from existing large code-bases (“Big Code”) is making synthesis into a practical reality . The purpose of this PoC is to develop a platform that would lead to commercialization of our technology to improve programming productivity and code quality. We target two closely related applications: (1) Providing automatic assistance in programming tasks by learning from existing code, and (2) Providing on-line assessment of code quality as it is being developed using learned models. These applications have the potential to dramatically reduce time-to-market of new software, and improve its quality and security.

Keywords: programming questions,semantic code search,big code,program analysis,static analysis,computer programming
High Performance Alexandrite Crystals and Coatings for High Power Space Applications (GALACTIC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Space
Theme: Enabling European competitiveness, non-dependence and innovation of the European space sector
Action type: Research and Innovation actions
Countries involved: Italy,Germany,Lithuania
Call: Technologies for European non-dependence and competitiveness (H2020-SPACE-2019, 2019)
Start date: 2020-01-01
End date: 2023-04-30
Duration (months): 40.0
Total project cost (EUR): 1999127.5
EU funding (EUR): 1999127.5
Participants: 4
Project status: SIGNED

Space-based earth observation missions are an essential building block gaining the data to understand our planet. In particular, space missions which are enhanced by laser-based instruments enable new ways of monitoring the atmosphere or the planet’s surface. The availability of space-qualified TRL 6 high performance coated Alexandrite laser crystals within Europe is a major enabling technology for future earth observation space missions. For this reason, the GALACTIC project aims for the creation of the complete supply chain solely by European industry for high performance, high quality, high power, coated Alexandrite laser crystals. For this goal, two industrial partners and a research institute team up to combine their complementing expertise and reach this ambitious goal. Optomaterials S.r.l. (Italy) as expert in single crystal growth will advance Alexandrite crystal growth and machining techniques to produce high-quality Alexandrite laser crystals. Altechna Coatings (Lithuania) will contribute its expertise on high performance optical coatings and characterization methods to develop space-compliant, highly durable optical coatings specifically tailored for Alexandrite pulsed laser operation. Laser Zentrum Hannover e.V. (Germany) as a research institute with strong experience in the development of laser sources for space applications will develop demonstrator laser systems based on the newly developed Alexandrite crystals proving their superior lasing performance. The combined forces of these outstanding partners will enable a detailed TRL 6 qualification of the coated Alexandrite crystals within the GALACTIC project making these crystals a new purely European product to be utilized in future space missions by the space industry. The development will by accompanied by strategic dissemination activities promoting the activities of GALACTIC to a broad audience.

Keywords: alexandrite crystals,space qualified laser crystals,optical coatings,trl 6,alexandrite laser systems
LOcalized Targeted Therapy to Avoid REcurrent GlioBlastoma Multiforme (Lottare GBM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Portugal
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

TargTex is a newly founded Portuguese startup with a novel concept to tackle the most lethal type of brain tumor – Glioblastoma Multiforme (GBM). GBM is the most common and aggressive type of primary brain tumor, with a survival rate lower than 5% after 2 years. The aggressiveness of the disease combined with the lack of effective treatments translates into a terrible prognosis to GBM patients, with a life expectancy of no more than 12 to 18 months after being diagnosed. TargTex team has developed a concerted approach, taking into consideration the needs and contributions from key stakeholders: patients, doctors and scientists. This innovative treatment (for which we have IP protecting the application) is based on a hydrogel formulation to be used as adjunct to surgery, applied after tumor resection. With a slow release from the hydrogel – over several weeks – the molecule is able to selectively kill GBM tumor cells that were not fully removed during surgery, thus offering a safer solution to neurosurgeons, who often deal with the conundrum of removing unaffected brain tissue to avoid tumor recurrence. In addition, this approach brings added benefits to the patients since the single treatment does not require further chemotherapy cycles. Most importantly, the active drug is a small molecule that binds to a specific target in GBM cells, and therefore, covers the whole patient population since it is not a personalized medicine. Our goal for the Phase 1 is to assess the technical, commercial and financial feasibility of TargTex. For that purpose, we will a) assess the regulatory framework and IP strategy to develop an adjunct to surgery in the context of GBM; 2) design the Toxicology & Safety Pharmacology experiments needed for an EMA’s Clinical Trial application; 3) assess the willingness to adoption of our solution from neuro-oncologists and neurosurgeons and 4) evaluate competition and assess the interest of investors and pharma towards our unique product.

Keywords: glioblastoma multiforme,adjunct to surgery,localized treatment,selectivity,hydrogel formulation
Explaining the winds of cool giant and supergiant stars with global 3D models (EXWINGS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe sciences
Panel description: Astro-physics/-chemistry/-biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Sweden
Call: ERC Advanced Grant (ERC-2019-ADG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 2456383.0
EU funding (EUR): 2456383.0
Participants: 1
Project status: SIGNED

Without stellar winds, life as we know it would not exist. Critical elements like carbon are produced inside luminous cool giant stars, transported to the surface by turbulent gas flows, and ejected into interstellar space by massive outflows of gas and dust. Direct evidence for this scenario comes in the form of dust grains produced in the stellar winds, and detected in meteorites by their isotopic composition. Nevertheless, the current understanding of stellar winds is far from sufficient to draw a realistic, quantitative picture of their effects on stellar evolution and their contribution to the enrichment of the interstellar medium with newly-produced elements and dust. Project EXWINGS aims at a breakthrough in understanding the winds of cool giant and supergiant stars with a novel modeling approach. We will produce global radiation-hydrodynamical ‘star-and-wind-in-a-box’ simulations, based on our recently-developed prototype. For the first time, it will be possible to follow the flow of matter, in full 3D geometry, all the way from the convective, pulsating interior of a cool giant, through its atmosphere and dust-formation zone, into the dust-driven wind region. Extending our unique approach to the warmer, more luminous red supergiants, we will explore alternative driving scenarios for their still enigmatic winds, involving magneto-hydrodynamic waves and radiation pressure on molecules and dust. The current progress in high-angular-resolution instruments, giving resolved views of the stellar atmospheres where the winds originate, presents an excellent opportunity for testing the new models. An ultimate goal is a predictive theory of mass loss and dust production in evolved stars, based on first physical principles. The results of EXWINGS will have a major impact on understanding stellar and galactic chemical evolution, on tracing the origin of building blocks for terrestrial planets, and on constraining physical properties of supernova progenitors.

Keywords: agb stars,red supergiants,stellar winds,stellar atmospheres,convection,mass loss,circumstellar matter,radiation hydrodynamics,numerical simulations,high angular resolution techniques,imaging,spectroscopy
SACCSCAN - personalising clinical management of major psychiatric disorders (SACCSCAN)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: SME instrument
Countries involved: United Kingdom
Call: Accelerating market introduction of ICT solutions for Health, Well-Being and Ageing Well (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-07-01
End date: 2016-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

1 in 5 of us experience mental health problems during our lifetime but more than 50% of patients don’t receive adequate care. Currently, when patients’ symptoms and behaviour don’t meet the criteria set out in the diagnostic manual, it may take up to 10 years to diagnose the illness. Delays in receiving a diagnosis can significantly impede delivery of the most effective treatment plan, exposing the patient to risk of further deterioration in well-being, reduction in quality of life leading to job loss, family breakdown, and self-harming. Mental ill health is now recognised as the largest cause of short and long term disability worldwide costing the global economy US$2.5T with a projected increase to over US$6T by 2030. SaccScan is a novel point-of-care (PoC) software diagnostic system which has been demonstrated to detect schizophrenia with better than 95% accuracy and has been extended with the same precision to bipolar disorder and major depression illnesses. The software diagnostic tool successfully utilises eye-movement abnormalities as clinical diagnostic biomarkers for serious mental illnesses. The test can be performed within 30 minutes and results produced over the internet at near real-time speed. Early economic modelling showed that introducing SaccScan into health care services could produce savings of €33 474 per patient in the case of suspected schizophrenia. The global market for this test is in excess of €5 billion with early-adopter customer segments making up over 10% of the total market - creating a potential initial market share of €100 million per annum. The purpose of this Phase 1 application is to demonstrate proof of business and develop the necessary partnerships for bringing a minimum viable version to market. Further support from H2020 SME Instrument, will help complete clinical validation and fully commercialise SaccScan in Phase 2 and Phase 3, while addressing the EU challenge of reducing healthcare costs through personalising medicine.

Keywords: personalised medicine,software diagnostic systems,mental health,major psychiatric disorders
Temporal mapping of environmental sensing transcription dynamics in Arabidopsis thaliana (plaNET-seq)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-05-11
End date: 2019-09-20
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

A common challenge for all organisms is to interact favourably with their environments. The blueprint to do so is in their DNA. We understand relatively well DNA units that code for proteins but cutting-edge genomic technologies have identified predominantly non-coding regions that respond to environmental cues. Thus, how widespread non-coding transcription may be functional represents a key question in modern biology. My proposal addresses this topic by studying nascent transcription by RNA Polymerase II (Pol II) during plant environmental interaction. The novel and innovative approach promises unprecedented detail and down to single nucleotide resolution of active Pol II transcription dynamics in response to environmental cues. It will capture non-coding transcripts before they are degraded, enabling us to investigate the molecular events in largely mysterious yet abundant components of the genomic blueprints of life. Owing to their sessile life-style, plants are experts in mediating compensatory regulation to respond to the environment. Hence, they are particularly promising models to yield answers to this contemporary scientific question. A major interest of the action will be how plants respond to low temperature. I will generate genomic maps of Pol II in the act of transcription that will reveal the dynamics of transcription in response to low temperatures. In a targeted approach, I will identify and characterise the dynamics of coding and non-coding transcription in the genomic regions responsible for cold acclimation. My strong background and solid track record, the expertise and potential of the host supervisor together with the infrastructure and encouraging scientific atmosphere at the host department will synergistically contribute to maximise the output of the proposal. It will strengthen the competitiveness of Europe and develop and diversify my skills as an independent researcher and prepare me for a successful career within academia.

Keywords: nascent elongation transcription sequencing,cold acclimation,arabidopsis thaliana,pol ii transcription,plant molecular biology