Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
From seed to seedling: Epigenetic mechanisms of priming to design strategies for crop improvement (EpiSeedLink)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,France,Ireland,Germany,Netherlands,Switzerland,United Kingdom
Call: MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 2924165.83
EU funding (EUR): 2689725.6
Participants: 22
Project status: SIGNED

The overreaching mission of EpiSeedLink is to foster a European network that empowers crop improvement through epigenetics by providing expertise, know-how, and creativity in high-end technologies to 11 early stage scientists and enabling them to translate scientific knowledge and skills into innovation. Through international, multidisciplinary, and inter-sectorial training in experimental and computational biology, EpiSeedLink will contribute to excellence in research and also timely address societal and agricultural needs. This original research program combines the unique know-how of academic experts with that of two companies to synergize research and knowledge transfer between a plant model and a crop of enormous agroeconomic importance (oilseed rape). EpiSeedLink will exploit the epigenetic regulation of seed priming mechanisms to improve crop performance under threats caused by climate change (i.e drought) through non-GMO practices. Crop breeding strategies have led to genetic erosion. A critical challenge is to identify new genetic and epigenetic markers for crop selection programs and for bioengineering the intrinsic performance of seeds or their enhancement through farming practices referred to as 'seed priming' strategies. These include chemical osmopriming and biostimulants use, that enhance germination efficiency and drought tolerance. Despite being a broadly adopted agriculture technique, the molecular determinants of seed priming are just starting to emerge and the nature, duration and implementation of plant priming remain poorly understood. These gaps in mechanistic understanding have so far precluded fully exploiting the biotechnological potential of seed priming. EpiSeedLink aims to fill these gaps by 1) understanding which chromatin regulatory layers contribute to improve plant performance to environmental threats through priming and by 2) exploiting epigenome diversity to provide markers of crop traits and strategies to the seed industry.

Keywords: seed priming,seed vigour,biostimulants,crop yield,oilseed rape,drought,stress,arabidopsis,seed germination,seedling establishment,climate change
Pregnancy- and Childbirth-Related Media Use to Support Maternal Mental Health (PACMUM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-01
End date: 2024-10-31
Duration (months): 24.0
Total project cost (EUR): 222727.68
EU funding (EUR): 222727.68
Participants: 1
Project status: CLOSED

This interdisciplinary research project is situated on the crossroads of women’s health and media psychology. The supervisor and the fellow, will combine their expertise to study how exposure to pregnancy- and childbirth-related content on the popular social media platform YouTube can affect pregnancy-related anxiety (PRA). We know from the women’s health literature that pregnancy-related anxiety is a serious issue and many pregnant women seek health information online, and we know from the media psychology literature that seeking online health information can affect cognitions and behaviors, but these two fields of research remain disconnected. By bridging the two research fields, the scattered research will be systematized and extended. We set forth 2 objectives, each comprising three research questions: to improve our understanding of how pregnancy- and childbirth-related content on YouTube can fulfill different needs for women with PRA (objective 1), and to elucidate the underlying processes of the association between exposure to pregnancy- and childbirth-related content and PRA (objective 2). To reach our objectives, we will use a multimethodological approach, in which we combine semi-structured interviews (Work package 1, objective 1) and a longitudinal panel study following a cohort of women throughout their pregnancy (WP2, objective 2). The longitudinal panel study will be incorporated in the large scale mobile application-based Mom2B project currently running at the Uppsala University, which combines automatically collected digital phenotyping data, self-report questionnaires, and objective information from national health registers. This project will significantly improve our understanding of how social media can be strategically used by researchers and health workers to improve public health, but also of how peers and influencers on social media can informally and often unintentionally play a role in their followers’ health behaviors and experiences.

Keywords: media effects media psychology women s mental health health communication
A web-platform interfaced software for spectroscopic molecular characterization and early diagnosis of Parkinson's disease (SEMISOFT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Italy
Call: ERC PROOF OF CONCEPT GRANTS2 (ERC-2022-POC2, 2022)
Start date: 2022-11-01
End date: 2024-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

The goal of this proposal is the production of the SEMISOFT software and an associate web platform for spectroscopic molecular characterization and early diagnosis of Parkinson’s disease. SEMISOFT will be designed to decipher complex IR/Raman spectra which are currently hampering development of new clinical protocols and other technological advances. This will be achieved upon implementation of the innovative semiclassically approximate quantum dynamics methods, developed in the parent ERC-CoG SEMICOMPLEX project, which allow for a simplification of complex spectra and unprecedented quantum mechanical accuracy. To further increase the level of accuracy in SEMISOFT simulations, a new machine-learning based force field for biological systems will be developed and incorporated in the software. The SEMISOFT web platform will be accessible to non-expert users from any browser without desktop installation and based on a flexible drop-down menu instructing the user step by step. The user will be able to reproduce IR/Raman spectra and identify molecular species in gas, liquid, or solid state. The web platform will find immediate application in a “freemium” version thanks to an industrial partner laboratory whose goal is to find biomarkers of Parkinson’s disease in human saliva. This pilot test will allow the team to tune the web platform for future commercialization. An analysis of economic, social and market prospects will be performed to define a value proposition and an appropriate business model, by comparing the feasibility and relative impact of licensing, paid access through a user account, and spin-off. The definition of an appropriate intellectual property protection strategy will be also part of the project. SEMISOFT is expected to have a long-term impact too. Raman and related spectroscopies are widespread in laboratories for chemical characterization and this computational tool will boost spectroscopy applications in material, physics and chemical sciences.
Unleashing AI potential to foster space accessibility and novel Earth Observation services creation. (Edge SpAIce)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Innovation actions
Countries involved: France,Switzerland,Bulgaria,Greece
Call: End-to-end Earth observation systems and associated services (HORIZON-CL4-2023-SPACE-01, 2023)
Start date: 2023-12-01
End date: 2026-11-30
Duration (months): 36.0
Total project cost (EUR): 3098625.38
EU funding (EUR): 2453522.1
Participants: 4
Project status: SIGNED

Satellites have become one of most prominent technologies for Earth Observation, progressively attracting large investments from both the private and public sector and potentially becoming the next life-changing trend in world economics. Resulting from technological advancements and gradual reduction in manufacturing and in-orbit deployment costs, data captured drastically increased along, revealing significant impairments in current data management infrastructure to maximise associated added value. With the purpose of achieving a more efficient data management to further approach novel EO applications requiring continuous data flow between capturing and processing, Deep Neural Networks (DNNs) deployment "at the edge" has been investigated as valid approach to allow autonomous and reliable data payload and latency reduction while keeping high added value from data captured. However, deployment of accurate DNNs models present several limitations, with the major ones being high computational power and cumbersome architectures. In this project proposal, Edge SpAIce develops an extremely efficient approach to resize complex DNNs while ensuring compatibility requirements for on-board satellites hardware are met. With this scope, Edge SpAIce will further target a challenging demonstration of Edge-AI potential by design and deployment of a DNN for marine plastic litter remote monitoring from in-orbit representative satellite, paving the way towards next generation EO and moving European leadership in the global space market.

Keywords: deep neural networks
Efficient Methanol from Pumped Heat and Calcium Looping (EMPHATICAL)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Industry
Destination: Climate neutral, Circular and Digitised Production
Action type: Innovation actions
Partnership: Processes4Planet (co-programmed)
Countries involved: Netherlands,Italy,Spain,Sweden,France,Belgium,United Kingdom,Poland,Finland,Switzerland,Germany
Call: Turning CO2 emissions from the process industry to feedstock (Processes4Planet partnership) (IA) (HORIZON-CL4-2024-TWIN-TRANSITION-01, 2024)
Start date: 2024-11-01
End date: 2029-04-30
Duration (months): 54.0
Total project cost (EUR): 19737818.75
EU funding (EUR): 17295057.0
Participants: 21
Project status: SIGNED

To achieve the 2050 climate goals, industries must transition to zero-emission and circular processes, crucial for the metallurgical industry facing challenges due to carbon dependence and difficult to abate emissions. Key to this transition is the integration of fluctuating renewable electricity sources, circular processes, and the production of versatile products like methanol. However, to overcome the challenges in e-methanol production, there is a need for technological breakthroughs for competitive renewable electricity and efficient CO2 utilisation. Energy-intensive sectors require low-cost, environmentally friendly CO2 capture systems. The integration of Power-to-Value systems presents a unique opportunity for a seamless transition to circular economies. EMPHATICAL targets residual CO/CO2 containing gases from highly electrified metallurgical industry, namely electrical and submerged arc furnace processes (EAF & SAF), through the energy efficient integration of innovative oxy-blown calcium-looping capture technology, purification, and conversion of CO2 to e-methanol with green H2 as a feedstock. Culminating in a first of a kind TRL7 demonstrator to establish economic viability and sustainability for achieving net zero in electrified metallurgical and methanol production. EMPHATICAL will demonstrate integrated concept at relevant scale for making decisions for the FOAK, taking overall conversion process from TRL5 to demonstration TRL7. The objective is to achieve a 25% reduction of the specific energy consumption and 25% decrease of the production costs. In this project, risks are mitigated from the start; each unit can be implemented as a stand-alone function within a modified state-of-the-art technology chain and thus provide immediate performance and energy efficiency improvements. The project evaluates EMPHATICAL concept integration in two industrial sites. The expected overall CO2 reduction for EMPHATICAL plants is projected to be 41 Mt/year by 2050.

Keywords: carbon capture and utilisation,metallurgical industry,industrial symbiosis,e methanol
Accelerating Local Innovation Ecosystems in Europe (ACCELERO)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Portugal,Belgium,Germany,Bulgaria,France,Poland
Call: Expanding Acceleration Ecosystems (HORIZON-EIE-2021-SCALEUP-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 1291678.57
EU funding (EUR): 998750.0
Participants: 6
Project status: CLOSED

Europe has been in the forefront for research and innovation, even though at different paces depending on specific location. In this context, ACCELERO – Accelerating Local Innovation Ecosystems in Europe aims at contributing to reverse the unbalanced business activity in Europe by increasing the attractiveness of (less advanced) ecosystems: making ‘modest’ and ‘moderate’ innovation ecosystems more attractive to local startups that will benefit from a strong local support and avoid relocation to EU hubs as well to international companies interested in setting up their businesses outside the established and well-known centres. It also aims at tapping into the potential of local ecosystems through co-designed programmes of activities proposed jointly by business acceleration entities located in less connected innovation ecosystems (‘modest’ and ‘moderate’) and innovation hubs (‘strong innovators’ and innovation leaders’), to improve the quality of business acceleration services, their network outreach and scale-up support. ACCELERO has the ambition of creating a pan-European community of business support organisations (BSOs) as the one-stop shop for all BSOs and its “customers”, the startups and SMEs, as well as for peer-to-peer exchange, networking and connectedness for all stakeholders engaged in the broader innovation ecosystem. This will be achieved with an initial ACCELERO extended community apart from consortium members to co-create and pilot-test high-quality business acceleration services with European BSOs from emerging and moderate innovators together with experts from strong and leader innovation regions or Member States, followed by the launch of the community inside Euroquity platform.
DROPLET MICROFLUIDIC 3D BIOFABRICATED HIGH-PERFORMANCE DNA-CARBON NANOTUBE DIGITAL ELECTRONICKS (3D-BRICKS-DROP)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Italy,Estonia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 28.0
Total project cost (EUR): 595000.0
EU funding (EUR): 595000.0
Participants: 2
Project status: SIGNED

Given current market demand and limitations of silicon complementary metal-oxide-semiconductor (CMOS) technology, alternative solutions for downscaling physical size and upscaling production volumes are needed. 3D-BRICKS proposes nanolithography-free biofabrication of 3D CNT-FETs, assembled into digital integrated circuits (ICs). State-of-the art CNT-FETs use planar layouts, but 3D-BRICKS increases integration via 3D stacked transistors. Upscaling fabrication needs innovative automated methods with built-in quality control, which are currently not available. Hence, 3D-BRICKS-DROP aims to take an interdisciplinary approach combining fluidics, electronics, biotechnology, material science and optics to build a platform that performs CNT-FET assembly in droplets, sorts them based on quality criteria and deposits high quality products on the target substrate.

Keywords: droplet microfluidic dna origami cnt fet nanoelectronics
Improving mental health, wellbeing, and resilience of healthcare workers in Changing Environments (APOLLO2028)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Ensuring access to innovative, sustainable and high-quality health-care
Action type: Research and Innovation actions
Countries involved: France,Italy,Lithuania,Sweden,Finland,Ireland,Hungary,United States
Call: Resilience and mental wellbeing of the health and care workforce (HORIZON-HLTH-2023-CARE-04, 2023)
Start date: 2024-01-01
End date: 2027-12-31
Duration (months): 48.0
Total project cost (EUR): 5626338.75
EU funding (EUR): 5626338.75
Participants: 12
Project status: SIGNED

The overall objective of the APOLLO2028 project is to provide health and care workers, organisations, and healthcare system funders and policy makers with research-backed innovative solutions to help improve mental health, wellbeing, and capacity to be more resilient to changing environments (especially daily pressures and extreme events) at the workplace. The originality of the project is to consider resilience in health care in a holistic approach to build individual, team and organizational capabilities to face the next extreme events and daily pressures. Therefore, we will study individual factors affecting resilience, group factors, organizational factors, and develop a model involving all types of factors. This model will serve as a basis for the production of guidelines to be disseminated to health and care workers, their managers, as well as policy makers and health systems funders. We will also develop an AI-based system to support in the identification of stress factors and recommend actions. We will involve all the stakeholders in a co-design work to finalise our solutions. We will also review the cost effectiveness of our solutions. The main impact of our project will be a reduction of stress factors at the workplace, and an improvement of resilience of all the health and care workers. We will ensure our solutions are disseminated to all EU member states and adapted to the specifics of each of their health care systems.

Keywords: resilience,individual resilience,organizational resilience
Friends with benefits – the role of endophytic bacteria in legume nodules containing nitrogen-fixing rhizobia (FITTER)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 199440.96
EU funding (EUR): 199440.96
Participants: 1
Project status: SIGNED

From shoot to root plants are exposed to a diverse range of microorganisms, which can play a major role in plant health, growth and development. A small fraction of bacteria can cause disease, the vast majority of bacteria has no known effect on the host, but there are bacteria that are beneficial to the plant. These microbes are able to protect plants from pathogens, modulate immune responses or assist in nutrient uptake. The best studied beneficial relationship for both plant and bacteria, is the long-term biological interaction (symbiosis) between legumes and nitrogen-fixing bacteria. These bacteria called rhizobia, are hosted in root nodules of legumes such as clover or alfalfa, where they fix atmospheric nitrogen. However, rhizobia are not the sole occupants of nodules and despite early findings of the presence of other nodule associated bacteria (NAB), the diversity and role of NAB in symbiosis and plant growth has remained neglected. Legumes are important crop in agriculture worldwide and as such, the potential of plant growth promoting bacteria and increase of nitrogen-fixation abilities is a major topic of research aiming to enhance agricultural productivity. Investigating the genetic material of all the microbes, the so-called microbiome, of legume root nodules, will allow investigation of genetic features of those bacteria, which contribute to increased plant growth and nutrient availability. Here, I will use a holistic sequencing approach to (i) unravel the diversity and metabolic properties of NAB in legume nodules and (ii) gain insights into the environmental factors affecting NAB community composition, (iii) determine to what extent the bacterial community in the soil (rhizosphere) drives nodule community composition. The proposed research will provide a better understanding of the biological role of all co-occurring bacteria in nodules, in the otherwise binary interaction of legume-rhizobia symbiosis.

Keywords: metagenomics,microbiome,symbiosis,rhizobia