Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Academic emotions in the AI learning era – Situational, individual and social aspects of emotional processes in technology-mediated learning (AI-EMOTION)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Soci al World and Its Interactions
Panel description: Sociology, social psychology, education  sciences , communication  studies
Countries involved: Finland
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 1498983.0
EU funding (EUR): 1498983.0
Participants: 1
Project status: SIGNED

Emotions are an integral part of learning. While the role of artificial intelligence (AI) in learning processes is constantly growing, critical gaps remain in understanding its impact on students’ emotions, wellbeing, and ultimately, learning outcomes. The AI-EMOTION project aims to uncover the potential and pitfalls of AI that extend beyond cognitive learning outcomes by investigating the affective processes and mechanisms of such technology-mediated learning. By employing a multidisciplinary approach that integrates educational sciences, computer science, and psychophysiology, the project seeks to understand the complex daily dynamics between technology-mediated learning, academic emotions, and students’ well-being. To ensure robust results in real-world settings, students’ emotional experiences and related physiological states are captured across authentic learning situations in real-time using smartphone questionnaires and wearable biometric sensors. The resulting data will provide a rich information source for analysing within-person emotional processes and individual and group-level differences, covering three educational levels from middle school to university. The findings of the AI-EMOTION project are expected to generate new theoretical leads for both academic emotion and human-computer interaction research. Furthermore, the project will develop novel multimodal methods for emotional data collection and analysis, making significant methodological contributions to the interdisciplinary science of human emotions. Ultimately, AI-EMOTION will provide insights for designing AI tools that are not only cognitively effective but also emotionally supportive for learners.

Keywords: academic emotions,digital learning technology,ai in education
Support to the Vice-Presidents of the ERC Scientific Council 2021-2022 (ERC VP CSA)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: ERC other
Action type: Coordination and support actions
Countries involved: Netherlands,Poland,Greece
Call: Support to the Vice-Chairs (HORIZON-ERC-2021-VICECHAIRS-IBA, 2021)
Start date: 2021-04-01
End date: 2023-03-31
Duration (months): 24.0
Total project cost (EUR): 517828.75
EU funding (EUR): 517828.75
Participants: 3
Project status: CLOSED

The European Research Council (ERC) provides a competitive platform for investigator-driven frontier research at the European level. It is led by a Scientific Council (ScC) consisting of 21 eminent scientists and their President, and it is this council that independently establishes and oversees the ERC's scientific management and the implementation of its Work Programme. This project aims to support the ERC Vice-Presidents, who act on an honorary basis, in the efficient and timely achievement of the ScC's goals in 2021 and 2022. This project will provide local administrative and advisory support to the three ERC Vice-Presidents. The staff supported by this project will provide analysis of the output of the ERC and the ScC to the Vice-Presidents, preparatory work for the meetings of the ScC, support with scientific outreach and representation, as well as maintaining a clear and efficient channel of communication between the Vice-Presidents and the ERC's Executive Agency. A key duty of the Vice-Presidents is maintaining the integrity of the ERC's evaluation panels, and the staff supported by this grant will facilitate this by providing detail information and analysis of potential panel members to the Vice-Presidents to allow them to take informed decisions on recruitment. The staff will also coordinate the invitation of new panel members and communicate with them during the recruitment process. The impact of the project will be to ensure the efficient and well-managed operation of the ScC. This support is required, as the duties of the Vice-Presidents demand a considerable portion of their time. By allowing the Vice-Presidents to effectively and efficiently perform their duties, this project will contribute significantly to the continued implementation of the ERC under Horizon Europe.

Keywords: erc scientific council,advisory support,administrative support,panel member recruitment,scientific outreach,liason with the erc executive agency
Developing Multifunctionally Optimal composite Structures for construction and transportation applications with an emphasis on environmental sustainability (MULTIOpStruct)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Belgium,Luxembourg
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-12-01
End date: 2025-11-30
Duration (months): 24.0
Total project cost (EUR): 175920.0
EU funding (EUR): 175920.0
Participants: 2
Project status: SIGNED

Due to unmitigated global warming, the EU has suffered unprecedented heatwaves in 2022 resulting in over 12,000 deaths and Europe's worst drought in 500 years. This is attributed to the heavily fuel-dependent construction and transportation sectors - collectively responsible for around 60% of EU's greenhouse gas emissions in 2020. The chief reason lies in these industries' over-reliance on legacy/outdated component architectures, with limited life-cycles and non-optimal functional performance. Consequently, there is an urgent ecological-societal need and associated research challenge for tailoring alternative optimized composite structures that are sustainable, eco-friendly and suited for commercial deployment. MultiOpStruct aims to deliver an integrated design environment capable of addressing these concerns by adopting a highly inter-disciplinary methodology inspired by the “material-by-design” outlook; and greatly expanding the current state-of-the-art by coordinating cutting edge research. On the modelling side, the work will develop a novel, rapid and high-fidelity physics-based method custom fit for analysing such complex components. On the design side, the project will deliver the first ever Hybrid Multiscale-Artificial Intelligence Topology Optimization toolbox for multifunctional lightweight Additively Manufactured (AM) Composite structures with increased durability and thermal-vibro-acoustic isolation; and decreased net-costs. This will reduce fuel dependency and associated emissions - and subsequently alleviate problems induced by climate change, e.g., glacier retreat. These goals are strongly aligned with the Circular Economic Action Plan, European Green Deal and Fit for 55 policy. For succesful completion, the proposed research plan brings together an enthusiastic and talented researcher with expertise in computational mechanics with an interdisciplinary team of internationally recognized research groups in applied mechanics and Additive Manufacturing.

Keywords: model order reduction,multiscale,topology optimization,data driven methods
From origins to adaptations: tracing the fundamental steps of Darwin’s finch evolution (EVOFINCH)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 236340.0
EU funding (EUR): 236340.0
Participants: 1
Project status: SIGNED

Rapid environmental and climatic changes threaten the world's biodiversity heritage, underscoring the importance of investigating species' adaptive potential. This task is now facilitated by the development of powerful sequencing technologies and advanced computational methods, together enabling a new wave of research into previously unattainable questions. EVOFINCH will focus on Darwin’s finches, where 18 species originated within the last million years from a common ancestor and has become one of the most iconic adaptive radiations. Due to the addition of a new closely related outgroup species to our genomic dataset and the implementation of new sequencing technologies together with cutting-edge computational methods, EVOFINCH will trace the main steps of the evolutionary history of Darwin’s finches with unprecedented resolution - from their origins to the history of their adaptation. With the support of the MSCA programme, I will first determine the phylogenetic relationship and compare long-read alignments between the new outgroup and Darwin's finches using comparative genomics and phylogenomics. Next, I will assess the severity of the bottleneck during the colonization of the Galapagos by quantifying the amount of lost genetic variability and identify mechanisms behind the recovery of such variability. Finally, I will trace the evolutionary history of the adaptive alleles underlying the key traits in Darwin’s finch evolution: their beak and body size. The project will shed new light on how evolutionary forces interplay to give rise to the observed Darwin’s finch diversity, and will enhance our understanding of species’ adaptive potential as well as their ability to recover from a population decline. EVOFINCH will be implemented at Uppsala University under the supervision of Professor Leif Andersson, and represents a springboard for the fellow to become and independent research leader in evolutionary biology.

Keywords: darwin s finch,adaptive radiation,restoration of genetic diversity,major histocompatibility complex,ancestral recombination graph
The function of B cells in myocardial infarction-accelerated atherosclerosis (The B-MIracle)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology  of ageing , pathophysiology, inter - organ and tissue communication, endocrinology, nutrition,  metabolism, interaction with the microbiome, non -communicable diseases including cancer (and except disorders of the nervous system  and immunity -related diseases)
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1475638.75
EU funding (EUR): 1475638.75
Participants: 1
Project status: SIGNED

Survivors of acute myocardial infarction (MI) are at a particularly high risk for accelerated atherosclerosis and recurrent atherothromobosis. Nevertheless, mechanistic preclinical studies in atherosclerosis research world-wide are typically conducted in unchallenged (without MI) atherosclerosis-prone mice and thus do not address the specific pathophysiology of post-MI atherosclerotic cardiovascular disease. We conducted a single-cell RNA sequencing coupled to B cell receptor (BCR) sequencing analysis of sorted CD45+ splenocytes from atherosclerosis-prone mice that were fed an atherogenic diet for eight weeks in total and were subjected four weeks after the initiation of the atherogenic diet feeding either to sham microsurgery or to permanent ligation of the left anterior descending coronary artery to induce MI. We found that splenic mature B lymphocytes from atherosclerotic mice that suffered an MI display altered glucocorticoid-induced responses and a more diversified BCR repertoire, which contains twelve unique clonotypes (named B-MIracle clones) that are not present in atherosclerotic mice without MI. Here, I aim a) to investigate the effect of glucocorticoid-induced signaling in B cells in post-MI atherosclerosis in vivo by employing mouse models that allow the inducible genetic manipulation of different components of the glucocorticoid-induced signaling axis, b) by utilizing the full heavy and light chain nucleotide sequences from our single cell BCR-seq data, to clone and produce the respective antibodies of the B-MIracle clones and examine their effect in accelerated atherosclerosis after MI in vivo, and c) to address the relevance of these findings in atherosclerosis progression in patients with a recent MI, by analyzing sorted peripheral B cell subsets and serum samples. These studies may lead to the identification of precise therapeutic targets for secondary prevention of cardiovascular disease.

Keywords: atherosclerosis,myocardial infarction,b lymphocytes
Ecosystems for Higher Education Inclusion: connecting underserved communities with higher education through participatory engagement and research methodologies (EHEI) (EHEI)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Romania,Spain,Italy,Austria,Greece,Hungary,Colombia,Mexico
Call: MSCA Staff Exchanges 2024 (HORIZON-MSCA-2024-SE-01, 2024)
Start date: 2025-10-01
End date: 2029-09-30
Duration (months): 48.0
Total project cost (EUR): 1357710.0
EU funding (EUR): 1357710.0
Participants: 16
Project status: SIGNED

The EHEI project is aimed at creating a sustainable network of ecosystems that bring together CSOs and Latin American and European academic institutions to better understand how persons from underserved communities envision their transitions to and from higher education, as well as their inclusion within higher education and how universities and educational and social services could be improved to better facilitate these transitions. The project will contribute to both knowledge production and social innovation through: (1) Enhancing the understanding of transitions to and from higher education as individual and collective processes from the perspective of underserved groups in an intersectional and global perspective, (2) creating reflective teaching and guidance practices to enhance inclusivity and effectiveness of pre-university and university services for underserved groups enhanced by a whole university approach to inclusive transformation, (3) crafting reflective spaces for underserved groups in relation to higher education inclusion and (4) refining interdisciplinary and intersectionally inclusive research methodologies to better study educational transition and inclusion processes. These will lead up to the emergence of a sustainable ecosystemic network that will work beyond the project to facilitate processes of higher education inclusion. Intersectoral, interdisciplinary and extra-European Staff exchanges are at the core of the project as they facilitate the creation of a European-Latin American ecosystemic network that will enhance intersectoral, interdisciplinary and international innovation and translate this innovation directly into social and educational impact through on the spot activities. Staff exchanges will allow partners to transfer immersive knowledge from the civil society to the academic sector, while research methodologies from the academic sector will enhance and catalyse research and innovation activities of civil society actors.
Deciphering Neurodegenerative Disease with fast 3D imaging & functional nanoscopy (QScope)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Condensed Matter Physics
Panel description: Structure, electronic properties, fluids, nanosciences, biological physics
Countries involved: Netherlands
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2024-11-01
End date: 2029-10-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Neurodegenerative diseases are incurable, progressive brain disorders associated with accumulation of aberrant protein aggregates with severe effects on movement and mental functioning. The mechanism leading to neurotoxicity is far from understood, due to our lack of insight into early processes. Recently, aberrant liquid-liquid phase separation has emerged as a new concept to explain protein aggregation in neurodegenerative disease. Here, I will investigate the biophysical basis of the formation of different material states of aggregates, by capitalizing on my expertise at the interface of single-molecule biophysics and quantitative, high-resolution imaging in cells. I propose to address the following key questions, with the use of cellular models of Huntington’s Disease (HD) complemented with well-controlled in vitro experiments: How do the physico-chemical properties of protein variants and the cellular environment influence aggregation and toxicity? What role does phase separation play in Huntington’s disease? How does prion-like spreading of extracellular protein interfere with local protein assemblies in cells? HD is caused by a gene defect resulting in aggregation-prone huntingtin protein. The diverse sizes (nm-μm) and conformations of the aggregates pose a remarkable challenge, and multiple complementary approaches are needed to unravel their morphology and physico-chemical properties. I will develop multimodal AI-informed quantitative microscopy and functional nanoscopy to decipher how aggregates in neurodegenerative disease form and mature. Importantly, we will work without tags and exploit virtually stained quantitative phase imaging to assess mechanical properties and cell pathophysiology, therefore minimizing interference with aggregation processes. The QScope project is expected to elucidate the role of protein aggregation and phase transitions, relevant for a broad variety of diseases, and to establish new label-free and super-resolution imaging.

Keywords: super resolution imaging
Bacteria Biofilm as bio-factory for tissue regeneration (BIOACTION)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Pathfinder
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Italy,Belgium,Spain,Lithuania,Switzerland
Call: EIC Pathfinder Open 2022 (HORIZON-EIC-2022-PATHFINDEROPEN-01, 2022)
Start date: 2023-04-01
End date: 2027-03-31
Duration (months): 48.0
Total project cost (EUR): 2903862.5
EU funding (EUR): 2903862.5
Participants: 7
Project status: SIGNED

BIOACTION aims at developing a new methodology in implant technology based on functionalized bio-hydrogels that will convert the negative occurrence of biofilm-associated infections, the primary cause of implant infections and failure, into a positive resource. The main goal of BIOACTION is to transform implant-associated bacteria for the programmable production of specific proteins for in vivo cell recruitment and tissue regeneration, exploiting gene sequences loaded on engineered liposomes and phages, bound to hydrogel scaffolds. BIOACTION will develop new biomimetic substrates that can transform biofilm into extracellular matrix for the regeneration of target tissues. It will establish a high versatile technology to be used as injectable materials and implant coatings for periodontal and peri-implant infection treatments. The proposed approach will be validated in two clinically relevant animal models: dental implant and permanent transcutaneous bone. BIOACTION, would radically advance the future of infection treatment by revolutionizing the classical approaches leading to the improvement of state of care, health outcomes and to achieve huge socio-economic benefits. The project isstrongly interdisciplinary in nature involving expertise biomaterials, synthetic biology, phage and liposome technology, medicine. As a results, this innovative approach will bring the research and knowledge far beyond the current state-of-the-art and will lead, through the planned validation, as proof-of-concept of new materials and technique with a broader application in regenerative medicine.

Keywords: bio hydrogels,bactofection,liposome,phages,hard tissue regeneration,processing technologies
Reconstructing fragmented bones, reconstructing fragmented lives (RECONSTRUCT)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Attracting and mobilising the best talents
Destination: Attracting and mobilising the best talents
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Cyprus,United Kingdom
Call: Fostering balanced brain circulation – ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04, 2022)
Start date: 2023-06-01
End date: 2025-05-31
Duration (months): 24.0
Total project cost (EUR): 164328.0
EU funding (EUR): 164328.0
Participants: 2
Project status: CLOSED

Human skeletal remains can offer key information on diverse aspects of past life but, like all archaeological materials, they only give a glimpse into the life of past individuals; hence, a fragmented perspective into our ancestors’ lives. Their interpretative potential is greatly inhibited by the fact that such remains are often found fragmented due to several anthropogenic and natural taphonomic agents, such as funerary treatment, animal activity, soil pressure and others. This fragmentation severely limits the information that may be extracted from human bones in terms of metric analysis, geometry and morphology. RECONSTRUCT aims at producing 3D morphable models for the main elements of the lower and upper limbs of the human skeleton, which will be then used to infer the missing morphology of fragmented or incomplete bones. In order to achieve this aim and address a major current limitation in human skeletal analysis, RECONSTRUCT will integrate approaches from osteoarchaeology, forensic anthropology, biology, engineering, and data science. The results of the project will maximize the information that may be extracted from bioarchaeological research, contributing to a more comprehensive assessment of past life parameters. RECONSTRUCT will also have major implications in forensic anthropology since the study of modern skeletal remains suffers from similar limitations in terms of partial preservation as those witnessed in archaeological bones. Finally, the source code and raw data emanating from RECONSTRUCT will be made open access, greatly enhancing the extension of this approach to zooarchaeology, palaeoanthropology, and the prosthetic implants industry.

Keywords: bioarchaeology forensic anthropology human osteology