Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
The role of the non-canonical death receptor signalling in cancer and immune cells (CHIRON)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Staff Exchanges
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Türkiye,Sweden,Hungary,France,Greece,Ireland,Switzerland
Call: MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01, 2022)
Start date: 2023-10-01
End date: 2027-09-30
Duration (months): 48.0
Total project cost (EUR): 1764428.57
EU funding (EUR): 1531800.0
Participants: 11
Project status: SIGNED

Immune surveillance refers to the ability of the immune system to efficiently induce cell death (apoptosis) in aberrant cells during the early stages of tumour development. This induction of cell death involves the binding of the death ligand TRAIL (TNF-related apoptosis-inducing ligand) to its death receptors (DRs) DR4 and DR5 on the target cell. However, tumour cells can escape this immune surveillance by switching the signalling downstream of DRs from the canonical pro-apoptotic signal towards a survival signal. Previous work from CHIRON partners highlights that this non-canonical DR-signalling regulates both tumour cell behaviour and immune cell functions, demonstrating its central role in understanding the tumour microenvironment. Yet, many aspects of the DR-signalling pathways remain unresolved, hampering the exploitation for diagnostic and therapeutic purposes. CHIRON will address these gaps via its main scientific aims: (i) to develop novel small molecule inhibitors (SMIs) to inhibit non-canonical DR-signalling (WP1), (ii) to identify new DR4- and DR5-binding partners within tumour and immune cells (WP2), and (iii) to gain a mechanistic understanding of the role of the non-canonical DR-signalling pathway in immune cells and cancer types (WP3). To achieve this, the CHIRON consortium combines the multidisciplinary and complementary expertise and resources of six academic and three private sector partners to (i) generate novel knowledge and innovative tools, (ii) strengthen an efficient network of knowledge exchange for further innovative synergies, and (iii) develop the expertise of early-stage and experienced researchers through excellent training. The outputs of the research will (i) develop novel tools to sensitise tumour cells for TRAIL-induced cell death, (ii) guide future diagnostic and therapeutic strategies to utilize and modulate DR-signalling, and (iii) train the expertise necessary to turn such knowledge into innovative services and products.

Keywords: trail,death receptors,dr4,dr5
European Knowledge Hub and Policy Testbed for Critical Infrastructure Protection (EU-CIP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Civil Security for Society
Theme: Civil Security for Society
Destination: Strengthened Security Research and Innovation
Action type: Coordination and support actions
Countries involved: Italy,Germany,Portugal,Ireland,Norway,Poland,Finland,Cyprus,Belgium,Greece,Spain,Romania,France
Call: Knowledge Networks for Security Research & Innovation (HORIZON-CL3-2021-SSRI-01, 2021)
Start date: 2022-10-01
End date: 2025-09-30
Duration (months): 36.0
Total project cost (EUR): 1999875.0
EU funding (EUR): 1999875.0
Participants: 20
Project status: SIGNED

The main goal of EU-CIP is to establish a novel pan European knowledge network for Resilient Infrastructures, which will enable policy makers to shape and produce data-driven evidence-based policies, while boosting the innovation capacity of Critical Infrastructures (CI) operators, authorities, and innovators (including SMEs). In this direction, the partners have already established the European Cluster for Securing Critical infrastructures (ECSCI), which brings together 22 projects that collaborate in CI Resilience. EU-CIP will leverage the capacity, organization, community, and achievements of the ECSCI cluster towards establishing an EU-wide knowledge network with advanced analytical and innovation support capabilities. The project’s analytics capabilities will fulfil the reporting requirements listed in the call in terms of the number and the (semestrial) frequency of the reports. To facilitate information collection and analysis, the project will establish a FAIR data observatory of research projects, research outcomes, technologies, standards, and policies. Along with analytical capabilities for evidence based policies, the project will organize and offer a rich set of innovation support services to EU projects and other innovators in CI security and resilience. These services will include training, support in business planning and access to finance, as well as support in the validation, standardization, and certification of novel solutions. The projects outcomes will be integrated and made available through a Knowledge Hub, which will provide a singly entry point to the EU-CIP results. EU-CIP will build a vibrant ecosystem of over 1000 stakeholders around this knowledge-hub. To animate and grow the project’s community, EU-CIP will execute an ambitious set of dissemination activities, including the establishment and organization of an annual conference on Critical Infrastructures Resilience, which will become a flagship event for critical infrastructures.

Keywords: resilient infrastructures,knowledge network,knowledge hub,cluster,information collection,information analysis,evidence based policies,exploitation of research outcomes,innovation support,vali
MAximising the synergy of European research Governance and Innovation for Climate Action (MAGICA)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Climate
Destination: Climate sciences and responses for the transformation towards climate neutrality
Action type: Coordination and support actions
Countries involved: Italy,Belgium,Portugal,Norway,Ireland,Austria,United Kingdom,Greece,Germany,Finland,France,Netherlands
Call: Maximising the impact and synergy of European climate change research and innovation (HORIZON-CL5-2021-D1-01, 2021)
Start date: 2022-06-01
End date: 2026-05-31
Duration (months): 48.0
Total project cost (EUR): 4827581.25
EU funding (EUR): 4827579.0
Participants: 26
Project status: SIGNED

This proposal will address area b of the call "Maximizing the synergy of climate change research and innovation in Europe ". MAGICA maximizes the synergies between infrastructure investments and initiatives of climate change research and innovation across the European Research Area (ERA) by building upon and further implementing the Mission of JPI Climate in support to the international and European climate agenda (including the European Green Deal and Adaptation Strategy). MAGICA aims to accelerate the development, provision and exchange of knowledge from research and innovation to inform and support policy-making and climate actions via a better coordination of on-going and future initiatives and a more efficient use of resources. MAGICA will be based on a circular and iterative interactions among the strategic, scientific and societal components of climate change research and innovation. A scientific arena will be created to enhance the debate and discussion within the scientific community on climate R&I priorities, that will be synthesized in a Joint Strategic Research and Innovation Agenda on climate change for ERA 2025-2034. In addition, the creation of a regular forum with European Ministries of Research and Climate and other funding bodies will foster the coordination of the different national research policies in order to meet the ERA-wide priorities and needs identified by the scientific community. Finally, a multi-directional dialogue with different relevant social actors (from policy-makers to the younger generation) will be enhanced through different international conferences (e.g. ECCA, Climate Neutrality Forum), workshops and other innovative formats in order to inform citizens but also to detect the social needs concerning the transition to climate-neutrality and climate science. They will be incorporated into scientific community’s priorities for research, thus closing the feedback loop.

Keywords: era,climate neutrality,climate adaptation,science policy society dialogue,open science,research funding,randi
Multi-functionalization of wood with bio-based approach MULTI-WOOD (MULTI-WOOD)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Slovenia
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-09-01
End date: 2025-08-31
Duration (months): 24.0
Total project cost (EUR): 155559.36
EU funding (EUR): 155559.36
Participants: 2
Project status: CLOSED

Wood is recognized as an attractive alternative to several traditional building solutions, and it is often called a “building material of the 21st century” since it can efficiently sequester carbon, balancing emissions from other materials. As a biological material, wood is sensitive to environmental conditions and microorganisms; therefore, it requires protective measures to extend its service life in outdoor applications. Despite the current demand for improvement of wood performance and considering technologies with low environmental impact, there is limited research on treatments and formulations that use green alternatives and improve critical properties simultaneously. The ambition of the MULTI-WOOD project is to provide multi-functional treatments to entirely protect wood from nano- to microscale using alternative sources of chemicals generated during the lignocellulosic bioconversion and/or from the pulp and paper industries. The project aims to develop innovative strategies for the improvement of four key wood properties: hygroscopicity, resistance against fire, UV, and biotic factors based on alternative, recently underutilized bio-based formulations. Proposed methodology and treatments target reduction in the toxicity of the modification processes, extend service life, elongate maintenance cycles, and thus, lower the negative impact on the environment. The MULTI-WOOD project will stimulate innovation and knowledge transfer between the host and ER by building a solid research and industrial network, organizing events, mentoring young researchers and managing projects, the ER will gain research and scientific skills and acquire a new set of competencies to reach professional maturity and independence after the fellowship.

Keywords: forest biomass residues,wood durability,biomaterials,bioactive compounds,fireproof products,multi functional properties,chemical modification,building materials
BIOS: The bio-intelligent DBTL cycle, a key enabler catalysing the industrial transformation towards sustainable biomanufacturing (BIOS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: Digital & Emerging Technologies for Competitiveness and Fit for the Green Deal
Action type: Research and Innovation actions
Countries involved: Germany,United Kingdom,Netherlands,France,Finland,Estonia
Call: Development of technologies/devices for bio-intelligent manufacturing (RIA) (HORIZON-CL4-2021-DIGITAL-EMERGING-01, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 6285668.25
EU funding (EUR): 6285167.75
Participants: 9
Project status: SIGNED

The usage of fossil resources leading to increasing atmospheric CO2 levels and global climate change should be rapidly replaced by implementing a circular economy. Circular bioeconomy converting sustainable substrates in moderately operating bioprocesses offers a plenitude of solutions. While synthetic biology provides a multitude of tools for strain engineering, their rapid use in hosts for optimal performance under industrial conditions is still challenging. Promising innovations are often trapped in the ‘valley-of-death’ as strain engineering faces a too complex space of putative manipulations. Novel approaches are needed to increase speed and success rate of strain and bioprocess engineering. The bio-intelligent approach, rigorously applied in BIOS, aims to accelerate and improve the conventional ‘design-build-test-learn’ (DBTL) cycle for strain and bioprocess engineering. Interdisciplinary collaboration will bridge microbiology, molecular biology, biochemical engineering with informatics, automation engineering, and mechanical engineering. Novel innovative metrics, biosensors, and bioactuators are developed for bi-directionally communication at biological-technical interfaces. Digital twins are created mimicking cellular and process levels. Integrating AI not only improves prediction quality but also enables hybrid learning, the key reason to increase speed and success rate in the novel bio-intelligent DBTL cycle (biDBTL). The power of biDBTL will be showcased by creating P. putida producer strains for terpenes, polyolefines, and methylacrylate. All are highly attractive products with a high potential for reducing anthropogenic greenhouse footprint. BIOS will open the door to a de-centralized, networked collaboration for strain and process engineering that efficiently links individual expertise for the sake of a symbiotic and rapid progress. BIOS also paves the way to de-centralized bio-manufacturing by implementing autonomous, self-controlled bioprocesses.

Keywords: bio intelligent,dbtl,ai,digital twin,biosensor,ale,p putida,terpenoid,polyolefine,methacrylate
Multiomics Profiling of Plants in Polluted Environments (MPOPPE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-06-16
End date: 2027-06-15
Duration (months): 24.0
Total project cost (EUR): 194074.56
EU funding (EUR): 194074.56
Participants: 1
Project status: SIGNED

Rice is a staple food for over half of the world’s population, making it vital to understand how pesticides affect its growth, productivity, and resilience. Current research often relies on single-omics methods, such as metabolomics or transcriptomics, which provide limited insight of the complete picture of the metabolic pathways impacted by pesticides. As a result, the complex interactions and adaptive mechanisms in rice remain poorly understood. Multi-omics approaches offer the potential to reveal these intricate metabolic networks and regulatory mechanisms affected by pesticides. The Multiomics Profiling of Plants in Polluted Environments (MPOPPE) Project aims to bridge this knowledge gap by investigating the molecular effects of commonly used pesticides on rice through an integrated analysis of transcriptomics, proteomics, and metabolomics. MPOPPE will examine gene expression changes, identify responsive proteins, and track metabolic alterations in rice plants exposed to selected pesticides. The project’s primary focus is to uncover the molecular pathways involved in stress response and detoxification mechanisms in rice. The MPOPPE project has three core objectives: (1) developing a multi-omics approach to elucidate plant adaptation and detoxification mechanisms in response to pollutants; (2) evaluating how diverse abiotic stress factors affect these mechanisms using multi-omics approaches; and (3) exploring the role of external detoxification agents in mitigating the harmful effects of pollutants on environmental systems. This research is expected to provide critical data that can guide the development of integrated pest management strategies to improve rice yield and promote environmental sustainability by advancing sustainable agricultural practices.

Keywords: multi omics approaches pesticide molecular mechanisms stress response environmental agriculture,integrated management strategies
Integrative breeding strategies for the transition of EUropean AQUAculture towards sustainable ORGanic production (EUAqua.Org) (EUAqua.Org)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Biodiversity and Ecosystem Services
Action type: Research and Innovation actions
Countries involved: Italy,United Kingdom,Spain,France,Portugal,Netherlands,Croatia
Call: Selective breeding programme for organic aquaculture (HORIZON-CL6-2024-BIODIV-01, 2024)
Start date: 2025-01-01
End date: 2028-12-31
Duration (months): 48.0
Total project cost (EUR): 2999312.25
EU funding (EUR): 2999312.25
Participants: 12
Project status: SIGNED

EUAqua.Org is aimed at boosting organic fish production in Europe by developing highly innovative solutions to fill key knowledge gaps and overcome the most relevant factors limiting the competitiveness for organic farming of Atlantic salmon, European sea bass, gilthead sea bream, and rainbow trout. Key technological advancements in phenotyping, genotyping, and genomic prediction methods will be developed by EUAqua.Org through the integration of different disciplines and approaches. This will provide essential tools for cost-effective, welfare- and environment-friendly organic aquaculture. The implementation of these tools at the industry level will be ensured by a comprehensive scientific, public, and industrial communication and dissemination programme, with exploitation of the project objectives and key results to create impact, including a multi-module open-access online training course that will be co-developed with key stakeholders (breeding companies, fish farmers, feed producers). In parallel, a tailored set of intervention strategies will be designed to promote awareness and acceptance of OA products in European consumers, through a behavioural economics approach. The project will build upon outputs of completed and ongoing national and EU projects, fully exploiting existing knowledge and leveraging the direct involvement of EUAqua.Org partners in multi-disciplinary research on advanced fish genomics, fish nutrition, fish health and welfare, consumer studies.

Keywords: genomic selection,functional genome annotation,cross generation genomic prediction,ai assisted phenotyping
Automated Synthesis of Algal Polysaccharides (ASAP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-12-01
End date: 2028-11-30
Duration (months): 60.0
Total project cost (EUR): 1962685.0
EU funding (EUR): 1962685.0
Participants: 1
Project status: SIGNED

Through photosynthesis, marine algae convert gigatonnes of carbon dioxide into carbohydrates every year. In the form of algal polysaccharides, these structurally complex biomolecules determine to a large extent how much carbon is stored in the oceans. Specialised marine bacteria unlock this carbon energy by breaking down the polysaccharides through the action of carbohydrate-active enzymes (CAZymes) and releasing the carbon dioxide back into the atmosphere. However, some of the polysaccharides are not recycled quickly, but sink into the deep sea and sediments, where they can store carbon for millennia. To better understand these processes, great efforts are needed to further explore the marine carbon cycle. The same advances are also important to support emerging efforts to use algal biomass as a new sustainable resource for the bioeconomy. The enzymatic machinery responsible for the degradation of polysaccharides by marine bacteria has remained largely unexplored because of the size and heterogeneity of algal polysaccharides. Pure and defined oligosaccharides needed for systematic screenings of marine CAZymes are currently not available. Since conventional chemical synthesis is time-consuming and often not general enough, ASAP aims to obtain collections of oligosaccharides related to different classes of algal polysaccharides by using automated glycan assembly (AGA) technology. Oligosaccharides with many different sequences and sulfation patterns will be prepared from small sets of monosaccharide building blocks. Incubation of the synthetic oligosaccharides with samples containing carbohydrate-degrading activity and subsequent HPLC-MS analysis of the degradation products will provide information on: 1) the collective enzyme activities of a bacterial community in seawater and sediment samples; 2) the abilities of individual bacterial strains to degrade specific polysaccharides; 3) the substrate specificities of purified CAZymes.

Keywords: synthetic carbohydrate chemistry,automated glycan assembly,carbohydrate active enzymes,polysaccharide degradation,marine polysaccharides,carrageenan,ulvan,fucoidan,alginate
The Microbiota-Root-Shoot Axis in Plant Health and Disease (MICROBIOSIS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-06-01
End date: 2028-05-31
Duration (months): 60.0
Total project cost (EUR): 1999975.25
EU funding (EUR): 1999975.0
Participants: 1
Project status: SIGNED

Since 450 million years, roots of healthy plant are colonised by diverse communities of bacteria, fungi, and oomycetes which are known to extend host functions by protecting roots from disease or by promoting water and nutrient acquisition. More remarkably, recent evidence suggests that bidirectional signalling between belowground microbial commensals and distant aboveground host organs is likely critical for maintaining host-microbe homeostasis and plant health. Reminiscent of the critical role of the microbiota-gut-brain axis for modulating brain functions in animals, we recently obtained evidence supporting the role of the microbiota-root-shoot axis for integrating response to microbes belowground and response to light aboveground. MICROBIOSIS aims at thoroughly dissecting the bi-directional connections between microbial root commensals and shoot developmental processes using Arabidopsis and tomato as model plant systems. By testing the hypothesis that co-evolutionary history between microbial root commensals and their hosts have shaped complex regulatory circuits modulating plant health, MICROBIOSIS aims at unravelling the physiological relevance of the microbiota-root-shoot axis for maintaining host-microbe homeostasis and for integrating multiple stress responses occurring in distant root and shoot organs. Using multi-kingdom synthetic microbial communities, cutting-edge metabolome, microbiome and grafting techniques, as well as several innovative and advanced gnotobiotic plant systems in which below-ground and aboveground organs are physically separated, MICROBIOSIS has the ambition to 1) bridge the gap between functional biology and ecology, 2) decrypt root microbiota-dependant regulatory circuits promoting plant health, and 3) design synthetic multi-kingdom microbial communities with modular functions favouring resistance to multiple aboveground stresses.

Keywords: plant microbiome,microbiota root shoot axis,synthetic communities,synthetic ecosystems,exudates,biotic and abiotic stresses,bacteria,fungi,oomycetes