Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
CleanTechBlock (CleanTechBlock)

Framework: Horizon 2020 — Societal Challenges
Programme: Climate action, environment,  resource efficiency and raw materials
Action type: SME instrument
Countries involved: Denmark
Call: Boosting the potential of small businesses for eco-innovation and a sustainable supply of raw materials (H2020-SMEINST-1-2015, 2015)
Start date: 2015-07-01
End date: 2015-11-30
Duration (months): 5.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

The building sector contributes with about 40% of total energy consumption in Europe, thus holding an immense potential for contribution towards CO2 emission reduction and energy savings. Graasten Brickworks aims to address this potential and gain access to a major market opportunity through the development of an innovative building material – CleanTechBlock - which will enable a paradigm shift within the construction process and recycling in Europe. CleanTechBlock is a patented multifunctional sandwich-block solution based on the combination of two clay brick shells and foamed recycled glass. The advantages of CleanTechBlock over bricks are compelling as the insulation, strength properties and construction price are similar to alternative solutions and it offers an overall increase in the inner space (3-5%) and a potential reduction in the overall house wall construction time (5x faster), while reducing maintenance requirements. In addition to the economic benefits, it can contribute to the mitigation of environmental problems – increase of waste recycling and decrease of raw material consumption, energy consumption and CO2 emissions (more than 50%). Our vision is to take the final steps of technological development and maturation towards industrial scale production of CleanTechBlock leveraging on the opportunity provided by the SME instrument. Besides giving the participating companies a technological leap with the consequent competitive advantage and export potential, the project will strengthen GB´s position in the clean-building materials field and assist Europe in achieving objectives for environmental and energy policy, both in terms of waste recycling and general reduction of CO2 emissions.

Keywords: building materials,glass waste recycling,bricks
SupramolecularlY eNgineered arCHitectures for optoelectRonics and photONICS: a multi-site initial training action (SYNCHRONICS)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Germany,Italy,Italy,Germany,Germany,Cyprus,France,United Kingdom,Canada,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-01-01
End date: 2019-12-31
Duration (months): 60.0
Total project cost (EUR): 3650589.0
EU funding (EUR): 3650589.0
Participants: 11
Project status: CLOSED

Photonics will play a major, enabling role in the future of ICT and healthcare. However, to fulfill its potential and deliver on its promises, photonics will heavily rely on novel and more performing materials, that can be manufactured cheaply for the specific requirements of photonic applications. To lead this “photonics revolution” and rip the societal benefits of being at the leading-edge of novel technological and scientific developments, the EC needs a highly-skilled scientific and technical workforce that can effectively implement the transition to a truly “knowledge-based society”. SYNCHRONICS mission is to synergistically address both needs by training a pool of future science-leaders in the synthesis, characterisation and application to photonics of supramolecularly-engineered functional materials within state-of the-art photonic nanostructures fabricated thanks to the top-quality facilities and unique expertise available within the network. This kind of research requires an inter-multidisciplinary, intersectorial approach by specialized and skilled scientists from different disciplines, each one bringing a particular expertise: organic and supramolecular synthesis (UNI-OX,UNI-W, SURFLAY), theory (UNI-GE, IBM, UNI-GE), surface studies (UdS, UCL), photophysics (IIT, IBM, UCL, UNI-GE,UNI-CY, UNI-MO), device fabrication and characterisation (IBM, AMO, SURFLAY, UCL, IIT, UNI-PI, UNI-GE). The SYNCHRONIX Network, through the trans-national and trans-disciplinary coordination and integration of these 12, highly specialised and internationally-leading teams, consolidates the European training efforts in the emerging area of both supramolecular nanoscience and nanophotonics. SYNCHRONICS will deliver 540 person-months of unparalleled multidisciplinary and intersectorial training that is carefully and intensively structured through local, network wide, and extra-network training in both scientific/technical topics, as well as complementary and managerial skills.

Keywords: organic photonics,organic lasers,all optical switching,supramolecular functional materials,rotaxanes,j aggregates,photonic crystals,opals,nanofabrication,scanning probes,self assembly,dbrs
Validation and Molecular Characterization of Novel Glucagon-Thyroid Hormone Conjugates for the Efficient Management of Dyslipidemia and Fatty Liver Disease (GCG-T3 Dyslipidemia)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-04-01
End date: 2018-05-30
Duration (months): 24.0
Total project cost (EUR): 171460.8
EU funding (EUR): 171460.8
Participants: 1
Project status: CLOSED

Cardiovascular disease (CVD) is a leading cause of death worldwide. Compelling evidence indicates that dyslipidemia represent a key risk factor for CVD. Among approved lipid-lowering agents, statins are the most effective therapy for CVD. However, a substantial portion of high-risk patients treated with statins fail to achieve target cholesterol levels required for preventing CVD. Thus, sufficiently efficacious and safe alternatives are urgently required. In addition, non-alcoholic fatty liver disease (NAFLD), the most frequent liver disease, contributes to dyslipidemia and accelerates CVD progression. However, limited therapeutic options are available for the treatment of NAFLD. Interestingly, the host group has developed a novel strategy of peptide-nuclear hormone conjugates that allows for peptide-mediated selective tissue targeting of nuclear hormones, which enables for synergistic benefits in target tissues while avoiding adverse effects in off-target tissues. The current project, aims to develop a novel poly-pharmaceutical therapy for the treatment of dyslipidemia and NAFLD by combining two key hormones in the control of lipid metabolism: glucagon and thyroid hormone (T3). To this end, the host group synthesized a series of glucagon-T3 conjugates to allow liver specific delivery of T3 aiming to reduce serum lipid levels and reverse hepatic steatosis, without causing adverse cardiovascular effects. During the implementation of this project the applicant will assess the in vivo efficacy of the conjugates in a series of rodent models of the metabolic syndrome, hypercholesterolemia and NAFLD. In addition, the applicant will characterize the molecular mechanisms by which the conjugates induce their metabolic benefits, while carefully assessing the potential adverse effects that the conjugates may cause in off-target tissues. This project may ultimately facilitate the discovery and the development of a novel and more effective therapy against dyslipidemia and NAFLD.

Keywords: cardiovascular disease atherosclerosis dyslipidemia thyroid hormone glucagon fatty liver disease ldl cholesterol polypharmacological therapy
MSCA FIRE: Fellows with Industrial Research Enhancement (MSCA FIRE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Co-funding of regional, national and international programmes (COFUND-DP) (H2020-MSCA-COFUND-2014, 2014)
Start date: 2015-09-28
End date: 2021-03-27
Duration (months): 66.0
Total project cost (EUR): 4185600.0
EU funding (EUR): 2092800.0
Participants: 1
Project status: CLOSED

MSCA FIRE: Fellows with Industrial Research Enhancement The FIRE programme is an integrated 4 year Doctoral Training programme, bringing together two national Centres for Doctoral Training: the Centre for Sustainable Chemical Technologies and the Centre for Digital Entertainment. The objectives of MSCA FIRE are to increase the international aspects of these successful intersectoral and inter-disciplinary programmes and to develop the elements of transnational mobility and career development, common to our industry facing doctoral programmes. Objectives are to: - Offer FIRE Fellows the benefits of two established national Doctoral Training Centres, as they expand their international company placement activities. - Bring Fellows the benefits of the cross-sectoral reach of both Centre, with vibrant industries. - Enhance interdisciplinarity and offer added-value training practices beyond their specialised research area, to all fellows. - Use these synergies to fire-up the fellows to become autonomous, creative, highly-skilled and fully ready for careers in international industries. This will be achieved by: - Implementing a combined 4 year doctoral training programme, - using two existing national Doctoral Training Centres and their already engaged industrial partners. MSCA FIRE will deliver: - 20 autonomous, creative, highly-skilled scientists and engineers fully ready for careers in international industries, and - A model for intersectoral, interdisciplinary doctoral training in an international environment. Industrial partners ensure that research carried out is relevant and will enhance employability of graduates, both in Europe and globally.

Keywords: interdisciplinary,intersectoral,international,doctoral training,industry partners,digital entertainment,sustainable chemical technologies
fAcilitating Public & Private secuRity operAtors to mitigate terrorIsm Scenarios against soft targEts (APPRAISE)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure societies - protecting freedom and security of Europe and its citizens
Theme: Fight crime, illegal trafficking and terrorism, including understanding and tackling terrorist ideas and beliefs
Action type: Innovation actions
Countries involved: Spain,Spain,Italy,Spain,Italy,Germany,Germany,Spain,Italy,Poland,Slovenia,Greece,Greece,Greece,Poland,France,France,France,United Kingdom,Portugal,United Kingdom
Call: Information and data stream management to fight against (cyber)crime and terrorism (H2020-SU-SEC-2020, 2020)
Start date: 2021-09-01
End date: 2024-02-29
Duration (months): 30.0
Total project cost (EUR): 9425581.75
EU funding (EUR): 7999101.25
Participants: 29
Project status: SIGNED

Ensuring public spaces safety while preserving the freedom of citizens represents a challenge for European societies. Soft targets like malls, stadiums or big events continue to face a variety of evolving cyber and physical threats. To secure public spaces and other soft targets requires an integral security approach and new concepts involving all the security actors along with private operators. APPRAISE aims to build on the latest advances in big data analysis, artificial intelligence, and advanced visualisation to create an integral security framework that will improve both the cyber/physical security and safety of public spaces by enabling a proactive, integrated, risk-based, and resilience-oriented approach. This framework will be designed to support the secured private-public collaboration and optimise the coordination of operations involving private security staff, private operators, and law enforcement agencies. APPRAISE will offer unprecedented capabilities to predict and identify criminal and terrorist acts and enhance the operational collaboration of security actors before, during, and after an incident occurs. Social, Ethical, Legal, and Privacy observatories bringing together LEAs, private operators, technology experts, psychologists, sociologists, and society representatives will ensure full conformity of the developed tools with current EU legislation and citizens’ acceptance, preparing the ground for successful exploitation. The consortium consists of world-class research centres, industries, SMEs, LEAs of different types (national police, municipal police, elite tactical unit) as well as private security practitioners and operators, coordinated by a large industrial company with a leading position in the security market. APPRAISE will demonstrate its solutions in four complementary pilot sites: a tennis tournament in Italy, a transnational cycling tour with stages in France and Spain, an international fair in Poland, and a mall in Slovenia.

Keywords: soft targets and public space protection,societal acceptance,internet content analysis,real time threat detection,actionable intelligence,public private collaboration,big data,digital twin
Deciphering the mechanism of irreversible replication fork arrest (Irrev Fork Arrest)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2020-04-01
End date: 2022-03-31
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

DNA replication is essential for cell proliferation. Obstacles to replication generate replication stress by stalling replication forks. In response to replication stress, cells activate the DNA damage checkpoint pathway that coordinates a cellular response to prevent DNA damage and ensure cell survival. One essential function of the checkpoint is to stabilise stalled replication forks and ensure that replication will resume after obstacles are removed. Specifically, the yeast checkpoint effector kinase Rad53 and its human counterpart Chk1 are essential to prevent irreversible replication fork arrest (IRFA), DNA damage and cell death under replication stress. A screen to identify factors required to promote IRFA has revealed a role for unrestricted recombination events in promoting IRFA. However, mechanistic studies are still required to understand how the checkpoint stabilises stalled forks and prevents IRFA. Recently, in vitro replication reconstitution with yeast purified proteins in the lab has helped uncover important mechanisms of DNA replication. I will use this system to reconstitute IRFA in vitro and determine the proteins and enzymatic activities required to promote IRFA in the absence of the checkpoint. I will then look for phosphorylation targets of Rad53 to understand how the checkpoint prevents IRFA. I will study changes at the DNA and replisome of stalled replication forks by 2D electrophoresis, mass spectrometry and cryo-EM to understand the causes of the irreversibility of IRFA. We seek to better characterise an essential function of the DNA damage checkpoint and define a new role for unrestricted recombination in promoting DNA damage. Main challenges of current cancer therapies include the appearance of surviving checkpoint-deficient cancer cells. Despite constant replication stress, it is unknown why these cells do not suffer irreversible fork arrest. Understanding IRFA could help design new therapies to target checkpoint-deficient cancer cells.

Keywords: dna replication,replication stress,dna damage,dna damage checkpoint pathway,fork stalling,ssdna,in vitro reconstitution,helicase,kinase,phosphorylation,fork restart,fork reversal
Resolving m6A-mediated post-transcriptional control in the human malaria parasite (PlasmoEpiRNA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: France
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-06-01
End date: 2026-05-31
Duration (months): 60.0
Total project cost (EUR): 1499553.0
EU funding (EUR): 1499553.0
Participants: 1
Project status: SIGNED

Post-transcriptional regulation in malaria parasites is key to the progression through different developmental stages of the complex life cycle within the human and mosquito host. This includes the asexual proliferation within human red blood cells that is responsible for all clinical symptoms of the disease and the preparation for the environmental changes accompanying transmission from host to vector and vice versa. Although the process that controls the destiny of mRNA are of critical importance to parasite survival and transmission, the molecular mechanisms orchestrating post-transcriptional regulation on a transcriptome-wide level remain largely unknown. We recently identified extensive methylation of adenosines (m6A) at internal mRNA positions as a new layer of post-transcriptional regulation of gene expression in Plasmodium falciparum. With m6A, the parasite dynamically modulates its transcriptome through selective mRNA degradation and/or translational repression of modified transcripts during blood-stage development. This new epitranscriptomic layer provides a previously missing link between the transcriptional program and the observed post-transcriptional events throughout P. falciparum development. The proposed project aims to elucidate how m6A mediates different outcomes of mRNA at key developmental stages of the parasite life cycle. We will 1) characterize m6A-binding proteins and elucidate how different m6A ‘readers’ translate this mRNA modification into distinct biological pathways (i.e. degradation, repression) during blood-stage development and 2) investigate how m6A and its specific reader proteins designate mRNAs to facilitate transient quiescence in transmission stages (i.e. gametocytes and sporozoites) to ‘prime’ the transcriptome for new host/vector environments. Overall, exploring the epitranscriptome of this parasite will reveal novel principles and molecular determinants of post-transcriptional control that can be targeted to combat malaria.

Keywords: m6a mrna methylation,plasmodium falciparum,host vector transmission,post transcriptional regulation,rna protein interaction
Intermolecular Asymmetric Halogenations of Olefins (AsymHalogenation)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 185857.2
EU funding (EUR): 185857.2
Participants: 1
Project status: CLOSED

The main goal of this project is the development and optimization of the first general methodology for intermolecular asymmetric halogenation of olefins and the application of NMR spectroscopy to understand and control this process. The carefully controlled application of nucleophiles in intermolecular asymmetric halogenation would be extremely desirable because it could be used as a powerful tool to generate a wide array of structural motifs of exceptional impact for the society. In this project, the asymmetric catalysis is proposed by stabilizing a bispyridine halonium complex in a chiral environment during both reaction with the olefin and subsequent attack of the nucleophile, i.e. a stoichiometric amount of stabilized complex will react with the double bond and then be exposed to the incoming nucleophile, all under the regime of the generated chiral environment. Thus, the project will encompass the synthesis of structurally diverse bispyridine ligands and their halonium complexes and then, the elucidation of the influencing factors on the kinetics of the halogenation reaction by UV and NMR spectroscopy. Ultimately, the knowledge gained in this part of the project will be transferred to the design of bispyridine ligands containing asymmetric centers to induce chirality in the halogenation reaction. One or several series of ligands will be produced and screened for chiral induction via chiral HPLC of the product mixture. The applicability of the approach on several different model reactions will be proven. The chiral products should be obtained with a high degree of regio- and enantioselectivity. The bispyridine ligand used to form the stabilized complex can be recovered by extraction or precipitation and therefore its use is expected to be feasible in large scale reactions. Chiral haloalkanes, the products of asymmetric halogenation, are crucial building blocks and intermediates for the synthesis of pharmaceuticals and functional materials, for example.

Keywords: asymmetric catalysis,halogenation,intermolecular nucleophilic addition,olefins,chirality,synthetic methods,nmr spectroscopy