Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Optimal Immigration Policy (OPIMPOL)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Individuals, Markets and Organisations
Panel description: Economics, finance , management
Countries involved: Spain
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2025-02-01
End date: 2030-01-31
Duration (months): 60.0
Total project cost (EUR): 1703225.0
EU funding (EUR): 1703225.0
Participants: 2
Project status: SIGNED

International migration affects the lives of millions, both at origin and at destination. It is known to generate aggregate benefits for destination countries even though labor market prospects of some natives may be worsened. Depending on the type of migrants, it can also benefit or harm origin countries. The design of immigration policies that maximize benefits, foster immigrant integration, and compensate potential losers is key for overall welfare. This project develops a systematic framework to design optimal immigration policies and provides a comprehensive evaluation of such policies’ welfare effects. We build our analysis focusing on five policy goals: i) redistribution policies that transfer some of the benefits from winners to losers; ii) optimal methods to assign immigrant visas; iii) preferential tax schemes for high-earning foreigners that encourage positive self-selection in skills; iv) selective immigration policies that are not detrimental, or even foster, origin countries’ economic development; and v) spatial allocation policies for immigrants that incentivize the accumulation of skills and assimilation. We develop and estimate a dynamic equilibrium framework to achieve these goals. The framework features, among others: human capital and labor supply decisions both at origin and destination; endogenous migration and return migration decisions; multiple sources of observed and unobserved heterogeneity; a worldwide general equilibrium that accounts for aggregate and idiosyncratic uncertainty; and the presence of knowledge spillovers and externalities from using skilled labor and capital equipment in production. The richness of the model and the variety of datasets used in estimation are unprecedented, which poses important methodological challenges. We develop novel estimation algorithms that allow us to address these challenges. We use the estimated model to design and evaluate optimal policies through simulations.

Keywords: immigration,migration decisions,optimal policy,labor markets,structural microeconometrics,equilibrium,dynamic discrete choice,taxation,ccp estimation
Exoteric and cryptic nitrogen, sulfur cycling in sponges along the oxic-anoxic continuum (SpongeMetabOxygen)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 247553.28
EU funding (EUR): 247553.28
Participants: 1
Project status: SIGNED

Sponges are considered to be one of the most ancient lineages of metazoans and are believed to have emerged amongst these early branching animal lineages at a time before the oceans became fully oxic around the middle to late Neoproterozoic Era (850-542 Mya). Sponges appear to retain some sort of ancestral memory of the hypoxic milieu from which they evolved and can still tolerate harsh hypoxic or anoxic conditions for relatively long periods. They express specialized anaerobic pathways that have been mostly lost in higher order animals such as fish and mammals, and yet remnants of these pathways persist primarily in the way they use the endogenously generated gases hydrogen sulfide and nitric oxide (NO) as signaling molecules for cellular homeostasis or as key players in cytoprotection during periods of hypoxic stress. Extensive sequencing of sponge microbiomes has primarily demonstrated the ubiquitous presence and expression of sponge symbiome pathways involved in NO generation via ammonia-oxidation and denitrification as well as the oxidation of reduced sulfur compounds, hinting at an active anaerobic lifestyle within sponges. Experimental demonstrations of these processes are rare in sponge holobionts and lacking in sponges sensu stricto who also express the relevant anerobic energy metabolisms. I will thus aim to demonstrate, disentangle, and integrate sponge holobiont metabolisms along the oxic-anoxic continuum by combining my expertise in sponge holobiont biogeochemistry and metabolic pathways with the expertise of the host in sponge physiology, nano-oxic O2 measurements at multiple spatial scales and dimensions, and advanced bioimaging techniques. The proposed multimethod and interdisciplinary study will thus provide an unprecedented view of sponge holobiont metabolism at the thermodynamic limit of animal life thereby providing further insights into higher animal responses to hypoxia and the future of animal life on a planet experiencing ocean deoxygenation.

Keywords: sponges anaerobic energy metabolism hypoxia anoxia oxygen host symbiont interactions hydrogen sulfide sulfur oxidation nitrite reduction nitric oxide ammonia oxidation denitrification
Artificial metalloenzymes Using SPY protein (U-SPY)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 1
Project status: SIGNED

Protein redesign allows to devise enzymes with new structure and functions, however, the introduction of artificial metal cofactors to a protein and tailoring the second coordination sphere of the metal centre remains challenging. SPY technology is a way to tackle these problems. In U-SPY this technology will be used to devise new artificial metalloenzymes capable for photostimulated reactions. This tagging system has been widely used but no examples are reported about SPY-based metalloenzymes. The SPY proteins will be obtained by the fusion of the SpyCatcher protein and the metalated SpyTag peptides containing copper and ruthenium metal centres. The computational design of the SPY systems will be followed by the synthesis, covalent modification and metalation of peptides (SpyTags). By the fusion of the various SpyTags and SpyCathers a library of SPY-based metalloenzymes will be developed, characterized and tested as catalysts for photostimulated reactions including atom transfer radical addition and isomerization reactions. This fellowship will give the opportunity to the candidate to spend 24 months in the University of Parma, under the supervision of Prof. Tegoni, who has a proven track record in the multidisciplinary field of bioinorganic and coordination chemistry, peptide design and photocatalysis. One of the project main expected results will be to prove the suitability of SPY technology for devising artificial metalloenzymes and the possibility to use these biocatalysts in the industry. The implementation of the project will exploit the researcher’s synthetic skills and will give him the chance to be an independent researcher in the future. It will also give the possibility to integrate him in the academic system by a tenure track position after the fellowship.

Keywords: peptide metal complex interaction,photocatalytic metal complexes,protein redesign
The Dance of Molecules: Rhythmic Systems through Organic Catalysis (DansMol)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Synthetic Chemistry and Materials
Panel description: New materials and new synthetic approaches, structure -properties relations, solid state chemistry, molecular architecture, organic chemistry
Countries involved: Netherlands
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Inspired by natural oscillatory systems that govern countless processes, from circadian rhythms to cellular metabolism, and the essential role of catalysis in both bio- and synthetic chemistry, this project aims to systematically design and construct modular, tunable organic chemical oscillators with catalytic functions. These oscillators will not only serve as time-keeping systems but also autonomously control and catalyze additional chemical reactions. The Belousov-Zhabotinsky reaction demonstrated that sustained chemical oscillations are possible, sparking decades of research. However, most existing chemical oscillators are based on redox chemistry and their harsh conditions and lack of versatility make them unsuitable for broader applications. In preliminary studies we developed the first catalytic oscillator based on small organic molecules. Building on this proof-of-concept, we propose to develop methods that allow the construction of biocompatible chemical oscillators tunable to a wide range of potential applications. The project is structured into three closely interconnected Work Packages (WP1-WP3). WP1 focuses on streamlining the design and optimization of oscillators using predictive models and parameter estimation techniques. WP2 will explore a variety of organic catalysts and solvents to create a versatile suite of oscillators with a diverse range of catalytic functions adaptable to various conditions. WP3 will explore a number of promising use cases of biocompatible catalytic oscillators to demonstrate their potential in real-world scenarios, including time-controlled polymerization processes and periodic drug synthesis. Integrating innovative computational modeling with automated experimental workflows will overcome the current limitations in oscillator design and pave the way for the systematic development of catalytic oscillators with specific, tailored properties, opening new frontiers in chemical synthesis, materials science, and beyond.
Recyclable polymers based on hybrid bicyclic lactones prepared by selective sp3 C-H activation (RePolHyCA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-10-01
End date: 2027-09-30
Duration (months): 24.0
Total project cost (EUR): 209914.56
EU funding (EUR): 209914.56
Participants: 1
Project status: SIGNED

As the world increasingly recognizes the urgency of sustainable resource management, the role of plastics has come under intense scrutiny. While commercial plastics offer essential benefits to modern society, their inherent drawbacks in end-of-life management have caused severe and long-lasting environmental damage. The REPOLHYCA project seeks to contribute to the crucial effort of developing next-generation plastics that combine high performance with full recyclability, aligning with the Plastics Strategy of the European Green Deal. The project will focus on aliphatic polyesters derived from bicyclic "hybrid" γ-butyrolactone monomers, which hold significant potential as useful and fully recyclable materials, capable of complete depolymerization back to their monomers, thus enabling a truly circular plastic economy. However, these materials’ performance and production costs are still unsatisfactory for commercial viability, mainly due to the complex and inefficient multistep processes required to access the monomers. The REPOLHYCA project aims to overcome these limitations by leveraging the expertise of Supervisor (Prof. Miquel Costas) in selective C-H functionalization and Fellow (Dr. Francesco Zaccaria) in catalytic polymerization. The project will develop an unprecedented library of structurally diverse hybrid lactone monomers using streamlined synthetic methodologies developed by the Supervisor’s group, enabling selective one-step γ-lactonization of abundant substrates (carboxylic acids) with earth-abundant metal catalysts (Mn) and environmentally friendly oxidants (hydrogen peroxide) under mild conditions. The Fellow’s expertise will then be applied to convert these new monomers into polyesters and assess their material properties and recyclability. The resulting structure-properties database will prove essential for identifying and designing advanced, sustainable polymers.

Keywords: c h oxidation,recyclable polymers,depolymerization,polyesters,ring opening polymerization
Evolution in the Gut in Health and Disease (EvoInHi)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Denmark,Portugal
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-09-01
End date: 2028-08-31
Duration (months): 60.0
Total project cost (EUR): 2499821.0
EU funding (EUR): 2499821.0
Participants: 3
Project status: SIGNED

The mammalian gut is an exquisite system to study ecology and evolution of microbes, and these processes are key for host-microbiome homeostasis. How microbiome diversity is maintained or lost is a critical question underlying the proper balance of this duet. Yet, our knowledge of the eco-evolutionary mechanisms structuring microbiomes is still in its infancy. Here, we seek to identify dominant modes of natural selection and host factors that modulate the evolution of their microbes. By leveraging knowledge on gene functions in specific strains and the power of mouse genetics and husbandry, we will unravel how natural selection operates to shape diversity in the bacteria that inhabit the guts of healthy and sick hosts. Microbiome evolution will be studied in several mouse models of disease with a focus on Escherichia coli as a pathobiont model, for which a deeper understanding of molecular mechanisms in health vs disease can be reached. Using long-term experimental evolution in vivo, high-throughput sequencing and theoretical modelling we will quantify the relative roles of directional, diversifying and fluctuating selection in gut evolution. We posit that resource competition drives the dominant selection mode in the healthy gut and that strong fluctuations in the environment, due to phage-bacteria co-evolution and/or due to hostmicrobe interactions, drive the selection mode in the gut of diseased hosts. We will further test the hypothesis that fluctuating selection leads to an Anna Karenina effect whereby the microbiomes of unhealthy individuals are much more distinct between one another than those of heathy ones. EvoInHi seeks to find the first empirical evidence that the predictability of evolution is higher in health than in disease, which will have a profound impact on understanding bacteria diversity and rates of specialization and how these can be used to modulate host health.

Keywords: natural selection,microbiome evolution,mouse models
Leverage synergy by cyber-physical systems for the convergence of the eco systems mobility, infrastructure and energy in the circular economy for the Society 5.0 (Cynergy4MIE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Public-private partnerships
Destination: Chips for Europe Initiative
Action type: Research and Innovation actions
Partnership: CHIPS (JU-JTI)
Countries involved: Austria,Czechia,Germany,Latvia,Finland,Greece,Cyprus,Netherlands,Slovakia,Belgium,Israel,Italy,Sweden,Lithuania,Taiwan, Province of China,United States,Japan
Call: Global call according to SRIA 2023 (RIA) (HORIZON-KDT-JU-2023-2-RIA, 2023)
Start date: 2024-09-01
End date: 2027-08-31
Duration (months): 36.0
Total project cost (EUR): 32600425.9
EU funding (EUR): 10288885.02
Participants: 45
Project status: SIGNED

Cynergy4MIE is a visionary project poised to revolutionize Europe's industrial landscape by bridging the gap between foundational technology layers, cross-sectional technologies, and key application areas. The project addresses the pressing need for efficient resource utilization and synergy creation across ecosystems. By actively managing requirements from various key application areas, Cynergy4MIE aims to steer developments in foundational technology layers and cross-sectional technologies, enabling unparalleled collaboration and resource optimization. This approach promises faster time-to-market, efficient resource utilization, and enhanced technological exchange between key application areas. Cynergy4MIE's strategy aligns with the EU's agenda and emphasizes urgency, resilience, technological partnerships, and cross-domain integration to champion European competitiveness. The project's long-term impact rests on embracing urgency, fostering competitive resilience, strengthening technological partnerships, harnessing ecosystem synergies, promoting cross-domain integration, advancing AI competence, prioritizing sustainability, enhancing productivity, and ensuring user-centric digitalization while forming strategic alliances. Cynergy4MIE envisions a future where emergent cyber-physical systems serve human-centric needs, drive domain convergence, and secure Europe's position as a global technology leader.

Keywords: ecosystem synergies,key application areas,digital ecs,synergetic ai,synergetic cps
Fine Line Dispensing Process to apply Narrow Metal Contacts onto Solar Cells (HighLine)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Germany
Call: EIC Accelerator Challenge: Technologies for ‘Fit for 55’ (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-02-01
End date: 2025-05-31
Duration (months): 28.0
Total project cost (EUR): 3575916.25
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

HighLine Technology GmbH is a ISE spin-off from Fraunhofer Institute for Solar Energy Systems with exclusive IP rights to redefine the standard METALLIZATION process to apply the small contact lines made of silver onto Si-solar cells. With silver costs for metallization as the 2nd most expensive step in solar cell production, the PV industry is being responsible for >10% of the global silver demand. When it comes to cell efficiency, mainstream PERC cells have achieved max 23.5% efficiency and €0.05/kW cost limits. The promising next step in cell technology/efficiency with Heterojunction cells (HJT) requires more than double the silver laydown compromising industry adoption despite its efficiency benefits above 26%. Designed to streamline metallization for today (PERC) and future (HJT) cells, HighLine FINE-LINE DISPENSING TECHNOLOGY enables cell producers the precise application of thinner contacts at 25% lower silver needs, 1% efficiency gains and 50% higher throughput.

Keywords: solar cell manufacturing
Final act of the autophagy symphony: Whole-organism orchestration of autophagy termination (FINALphagy)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Norway
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-01-01
End date: 2027-12-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 2
Project status: SIGNED

When an organism experiences physiological stresses, such as nutrient starvation, it activates several mechanisms to promote its survival. One of these mechanisms is autophagy, which is a catabolic pathway conserved from yeast to man that functions as a recycling system during normal physiology, and which helps provide nutrients to sustain essential cellular processes during starvation. Although autophagy is an intensively studied process that plays a major role both in normal development and in a wide variety of diseases, several important aspects of autophagy remain to be elucidated. For instance, whereas the vast majority of studies have focused on how cells regulate the activation of autophagy, it remains largely unknown how cells and organisms shut off autophagy in response to returning nutrient availability. The limited knowledge of autophagy termination is partly due to a lack of available tools and appropriate methods. Addressing these challenges will not only provide important insight in this fundamental aspect of the autophagic process, but may potentially also identify new targets for development of drugs to manipulate this phase of autophagy. In FINALphagy I will develop new genetic and computational tools to quantify and manipulate the temporal dynamics of autophagy in an entire organism. I will unravel key mechanism of autophagy termination in individual cells within a tissue and dissect how this connects to systemic signaling and behavioral changes. This will generate a comprehensive toolbox for time- and space-resolved manipulation and quantification of autophagy levels, produce a whole-organism map of autophagy responses at the tissue-level, and conceptualize our understanding of the dynamics of autophagy regulation in an entire organism during changing nutrient levels.

Keywords: autophagy,drosophila,in vivo imaging,machine learning,metabolism,systemic signaling,mathematical modeling