Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Product validation of Software Defined Radio Chip for RRH that supports multiple frequency channels and ranges from Sub-6GHz to millimetre waves (mmWave) (Siklu)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Israel
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-12-01
End date: 2020-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In order to meet the demanding needs of the high 5G capabilities, massive indoor deployment is needed for cellular coverage. This is achieved through Remote Radio Heads (RRH) working at multiple frequency bands – a key component of the 5G infrastructure market (~$10B by 2023). With the ongoing transition to V-RAN (cloud) based network architecture, there is a strong need for new flexible, optimized and cost-effective solutions that will enable the eco-system with sustainable business cases and ROI. To meet this need, Siklu is developing a Software Defined Radio (SDR) Chip for RRH that supports multiple frequency channels and ranges from Sub-6GHz to millimetre waves (mmWave). This highly integrated chip replaces more than 10 existing chips, cuts cost by 80%, and provides future flexibility and scalability, disrupting price and performance for indoor and outdoor RRH at any combination of mmWave, sub 6GHz frequencies and channel bandwidths. This game changer chip is based on Siklu’s unique, patent pending architecture. Siklu will utilize the 5G SDR chip for RRH for its internal portfolio of products, as well as sell the chipset, reference design and firmware / software to ODM / OEM building variety of indoor / outdoor products and solutions. The 5G SDR RRH will be developed in close alignment with lead customers and partners, who will be the first customers for a rapid volume ramp-up. Participation in o-RAN and other eco-system forums will help to accelerate the adoption and deployment of this technology. During phase one of this project, Siklu will complete analysis of both the technological feasibility and economic viability of 5G SDR RRH product, based on extensive market validation process. The purpose of this validation process is to assess all technical and business aspects and conclude the final requirements and specs of this disruptive technology / product with a viable business opportunity, including a strong EU perspective.

Keywords: 5g networks infrastructure,remote radio head,small cells,cloud,virtual radio access networks,5g infrastructure rfic and mixed signal
The consequences of temperature-resource interactions for the future of marine phytoplankton communities (TROPHY)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-04-01
End date: 2020-03-31
Duration (months): 24.0
Total project cost (EUR): 212194.8
EU funding (EUR): 212194.8
Participants: 1
Project status: CLOSED

Temperature, nutrients and light drive the growth of phytoplankton, aquatic photosynthetic microbes responsible for nearly half of global primary production. Because phytoplankton influence global biogeochemical cycles, carbon sequestration and climate, accurately modelling their growth is vital to forecasting our future. However, the models we use for global ecosystem forecasts do not consider how these factors interact, even though the interactions lead to qualitative and quantitative differences in outcomes. My goal is to therefore build a mechanistic understanding of how temperature and resources interact to influence phytoplankton growth, productivity and biogeochemical cycles. This project has three objectives (i) develop statistical models describing how phytoplankton growth changes as a joint function of temperature, nutrients and light, (ii) develop mechanistic models characterising how temperature and resources influence cellular processes in phytoplankton, and ultimately their growth, and (iii) implement dynamic versions of the mechanistic model to forecast how marine phytoplankton communities will respond to future changes in temperature, resources and predation. My work will involve applying machine learning techniques to published laboratory and field datasets to understand complex interactions between the three factors. By combining this understanding with insights from ecological theory, I will generate an accurate mechanistic model of growth, and then test the power of this model to predict patterns in the ocean using independent field datasets. Finally, I will use the validated mechanistic model to forecast changes to global patterns in phytoplankton growth and primary productivity. This project will enable us to generate credible forecasts of phytoplankton productivity and biogeochemical cycles in a warming ocean, and improve our understanding of fundamental ecological processes by uniting major fields of ecological theory.

Keywords: phytoplankton,temperature,nutrients,light,predation,machine learning,statistics,ecological theory
Drug Repurposing for Malaria Chemoprotection (REUSE4MALARIA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Portugal
Call: ERC Proof of Concept Grant (ERC-2015-PoC, 2015)
Start date: 2016-12-01
End date: 2018-05-31
Duration (months): 18.0
Total project cost (EUR): 145500.0
EU funding (EUR): 145500.0
Participants: 1
Project status: CLOSED

Malaria is a serious parasitic disease afflicting 198 million people in 2013, with an estimated death toll of approximately 600 000. Approximately half the world’s population is at risk of malaria. So far there is no cure/vaccine against malaria and current chemoprotective treatments have shortcomings, such as: 1) Limited Number of Drugs effective against malaria parasites; 2) Adverse Side Effects (observed in 32% to 44% of users); 3) Parasite Resistance to most of the drugs used for prevention and treatment; and 4) Limited Use (restrictions on age, genetic traits, pregnancy, etc). Our ERC-funded research uncovered a novel mechanism of action that can be targeted for malaria chemoprotection, with fewer side effects and reduced propensity to generate parasite resistance, on which we filed for IP protection. Furthermore, we have identified a set of likely drug candidates already validated in the clinic, which are likely candidates for malaria chemoprotection. In fact, our preliminary data indicates that a known anti-diabetic drug significantly affects parasite growth. We are seeking funding to initiate pre-clinical studies for repurposing this drug for malaria chemoprotection. This PoC funding will allow us to complete the following aims: 1) in vitro profiling to define therapeutic dose for malaria chemoprotection; 2) in vivo profiling to perform efficacy and toxicity studies; 3) further define IP Strategy; 4) draft early stage Regulatory Approval Roadmap; 5) conduct Market Analysis and develop a Business Case.

Keywords: malaria,nutrient sensing,chemoprotection treatment,metformin
A medical device for airflow simulation of the human upper airways (NASALFLOW)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-06-01
End date: 2019-09-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Nasal airway obstruction (NAO) can be defined as nasal ventilatory difficulty of a patient that is unable to achieve enough air volume in the upper airways to keep a quiet breathing without perception of obstruction or resistance. From 30% to 40% of population suffer from NAO, 259 million people in Europe alone. Some of the patients suffering nasal diseases need to undergo surgery, a procedure that is potentially hazardous for the patient, but also very expensive for patients and governments. The value of the worldwide medical technology market will reach €458.7bn by 2022, growing at a rate of 5.1% per year between 2016 and 2022. Nowadays, the most used tests by the clinicians are Peak nasal inspiratory flow, Acoustic Rhinometry and Rhinomanometry. These tools are rarely used in clinical practise due to its limitations. Hence, there is an upcoming need for new objective and accurate technologies that provide more detailed information about the airflow patterns inside nasal cavity. The revolutionary NASAL~ FLOW® is an automatized medical device based on the Computer Fluids Dynamics (CFD) analysis of human nasal cavities. A standardised procedure is set to study systematically the flow patterns of each patient and provides a huge amount of medical information that traditional methods are not able to obtain. In addition, it embedded a Virtual Surgery tool (VS), where several surgery methodologies can be assessed computationally without invasive procedures for the patient, saving time and money for health system. This approach will help in diagnosis and surgical planning for nasal diseases. N.A.S.A.L. is a Spanish SME founded in 2008, dealing with the improvement and updating of the medical procedures used in the Ear, Nose and Throat field and the patients’ well-being, through the development of applications that facilitate daily work and the decision-making of the doctors. NASAL~ FLOW® will boost the company revenues streams over a new market niche.

Keywords: simulation,airflow,nasal cavity,virtual surgery,diagnostic imaging,rhinometry,rhinology,rhinomanometry,automatisation,segmentation,3d reconstruction,clinical trial,ce mark
QSAR computational models' self-using platform for EC Regulation-REACH (QSAREACH)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Spain
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-09-01
End date: 2019-02-28
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Chemicals substances are presented in daily life like cosmetics, functional food or agro-industry. The EC Regulation 1907/2006 for Registration, Evaluation, Authorization and Restriction of Chemicals (REACH), for the production and use of chemicals when they are produced/imported in/to Europe in an amount greater than 1 ton/year has two major and clear customer paint points: first, REACH implies very high costs due to the experimental and administrative work required, which represents a particularly sensitive issue for SMEs. Second, REACH implies the need for a huge number of animal tests to demonstrate the safety of chemicals under approval. Animal experiments require much time for preparation and execution, and are expensive and ethically questionable. Instead, QSAR computational models represent significant savings in time, resources and money, since the applicability of predictive models is ease and immediate. And this business need from the European chemical industry SMEs is our market opportunity, by the final development of a novel high scalable technological platform of easy access to experienced and non-experienced end-users. These platform will include QSAR models of (eco)toxicology of chemicals -including nanomaterials (NMs)- to comply with the strict EC Regulation, where assays with animals in some specific domains, such as cosmetic, are completely forbidden. This customer self-using platform will include an additional tool for the evaluation of the appropriateness of replacing the chemicals studied for alternative compounds which a safer (eco)toxicological profile. ProtoQSAR is a five years’ company that arises from more than fifteen years of activity and experience of its team members, both academic and industrial sides, currently providing consulting services related to these predictive models used by different industries. Our goal is to make the leap from consulting through the validation and scaling up this high-potential opportunity in its sector.

Keywords: reach registration,chemoinformatics,computational models,qsar,nanomaterials
Layer-by-layer Assembly of Two-dimensional Polymer/ Graphene Heterostructures as Wafer-scale Flexible Opto-electronics (2DvdWHs)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-02-01
End date: 2022-05-03
Duration (months): 24.0
Total project cost (EUR): 212933.76
EU funding (EUR): 212933.76
Participants: 1
Project status: CLOSED

Van der Waals heterostructures (vdWHs) of atomically thin, two-dimensional (2D) materials have been attracting a wide range of research interests since their unique structures enable tunable and customized optical, electronic and magnetic properties. The vertical layer-by-layer assembly strategies make it feasible to mix and match different 2D materials into various vdWHs without the restraint of lattice matching and processing compatibility. Currently, however, most of 2D vdWHs (termed ‘2DvdWHs’) are predominantly based on inorganic sandwich complexes, especially on graphene, transition metal dichalcogenides (TMDCs) and hexagonal boron-nitride (hBN). What’s more, the vertical assembly method for 2DvdWHs mainly limits to small-scale proof-of-concept demonstrations. Consequently, I will develop a new generation of vdWHs through layer-by-layer assembling monolayer 2D polymers (2DPs) with monolayer graphene (Gr) for wafer-scale, flexible opto-electronics. The 2D organic-inorganic interface can engineer the field-induced charge-carrier transport within the 2DP-Gr heterostructures, and thus tailor their opto-electronic properties. The core technology is the advanced monolayer 2DPs synthesized at the air/water interface via Langmuir–Blodgett (LB) techniques based on photo-active conjugated monomers, such as porphyrin and pyrene derivatives. The resulting 2DPs are designed to be freestanding, monolayer semi-conductors with tuned band gaps and photo responses. Importantly, this technology can be extended to other 2D materials (e.g. TMDCs and hBN) and monomers, which structures can be further optimized for the better flexibility of the band gaps, higher enhancement of the charge transfer, and the new introduction of the photoactivity. A critical aspect of the work will be the use of customized 2DPs to integrate with Gr as wafer-scale, tunable 2DvdWHs and to study the unique quantum phenomena that arise from the organic-inorganic interlayer coupling.

Keywords: two dimensional polymers,graphene,van der waals heterostructures,opto electronics,water interfaces,layer by layer assembly,wafer scale
High Throughput Bioprinting of Tumour Models for Drug Development and Oncology Research (TUMOURPRINT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-2, 2018)
Start date: 2018-09-01
End date: 2021-01-31
Duration (months): 29.0
Total project cost (EUR): 3500467.5
EU funding (EUR): 2450327.25
Participants: 1
Project status: CLOSED

CELLINK will develop and commercialise TumourPrint - a high throughput platform for bioprinting of live tumour models for pharmaceutical drug development and large-scale cancer research. Bioprinting constitutes the most advanced method for fabricating fidel tissue models, using live cells in combination with cell-instructive bioinks (specially formulated hydrogels that provide cells with an optimal environment for survival, growth and proper 3D development). The high throughput platform - completely new to the market - is designed according to user needs. It will revolutionise drug development processes through serial production of fidel cancer models in an automated, precise and reproducible way. The platform offers unparalleled printing capacity and is integrated with robotics and none-destructive analytical methods capable of scoring drug responses in printed constructs. Current oncology approaches principally rely on unsatisfactory 2D mono-cell cultures and animal models to predict outcomes in humans, resulting in exasperatingly high attrition rates of cancer drug candidates in clinical trials. The economic and ethically challenging implications of failed trials provide CELLINK with a unique value proposition to drive willingness-to-pay for their disruptive platform. TumourPrint will address today’s pharmaceutical challenges by producing tumour models capable of mimicking size, heterogeneity and vascularity of the human tumour microenvironment in a fidel way. CELLINK has a proven track-record of successfully developing and commercialising products according to user needs; they developed the world’s first universal bioink, have commercialized three generations of bioprinters and optimised 18 cell-specific bioinks. Since the company’s establishment in 2016, CELLINK has commercialised its technology in over 40 countries, grown its organisation ten-fold and secured collaborations with several global pharmaceutical giants.

Keywords: high throughput 3d bioprinting,tumour models,drug discovery
Dynamic electromechanical control of semiconductor nanostructures by acoustic fields (SAWTrain)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Innovative Training Networks (ITN)-European Training Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Spain,Spain,Germany,Italy,Germany,Sweden,France,Netherlands,United Kingdom
Call: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) (H2020-MSCA-ITN-2014, 2014)
Start date: 2015-06-01
End date: 2019-05-31
Duration (months): 48.0
Total project cost (EUR): 3855693.24
EU funding (EUR): 3855693.24
Participants: 10
Project status: CLOSED

The dynamic modulation of semiconductor structures using vibrations provides a powerful tool for the control of the materials properties required for novel functionalities. Surface acoustic waves (SAWs) with GHz-frequencies and micrometre-size wavelength can be generated using piezoelectric transducers fabricated with standard integrated circuit technology. Their small propagation velocity and high sensitivity to disturbances confined to a superficial region have long been exploited in electronic signal processing and sensor applications. The SAW-induced modulation of the electro-optical properties of semiconductor structures is now been used for a wide range of applications including advanced sensors, the control of chemical processes, as well as the coherent control of carriers, spins, photons, and phonons down to the single-particle level. The latter are presently been exploited for different functionalities including advanced waveguide modulators, tuneable optical resonators, and single-electron pumps and single-photon sources. SAWTrain puts together leading groups from Europe, Asia and North America working on SAWs on semiconductor and related nanostructures to create a PhD training network. The synergy resulting from the expertise of these groups will provide PhD students with training opportunities far superior to those offered in existing PhD programmes. Training in research skills with secondments at different hosts will cover state-of-the-art research in the interdisciplinary areas of basic physics, materials, technology, and device concepts related to SAWs. This will be achieved by exposing the trainees to multiple secondments, mandatory co-supervision from different institutions, including a non-academic mentorship. The coordinated training will further contain topical courses, schools, conferences, and workshops and be complemented by measures to develop key competences and transferable skills, fostering the future career plan of the young researchers.

Keywords: semiconductors,acoustics,quantum information,single photon sources
Transgenerational epigenetic inheritance of chromatin states : the role of Polycomb and 3D chromosome architecture (3DEpi)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Integrative Biology: from Genes and Genomes to Systems
Panel description: Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicine
Countries involved: France
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-11-01
End date: 2024-10-31
Duration (months): 72.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 2
Project status: SIGNED

Epigenetic inheritance entails transmission of phenotypic traits not encoded in the DNA sequence and, in the most extreme case, Transgenerational Epigenetic Inheritance (TEI) involves transmission of memory through multiple generations. Very little is known on the mechanisms governing TEI and this is the subject of the present proposal. By transiently enhancing long-range chromatin interactions, we recently established isogenic Drosophila epilines that carry stable alternative epialleles, defined by differential levels of the Polycomb-dependent H3K27me3 mark. Furthermore, we extended our paradigm to natural phenotypes. These are ideal systems to study the role of Polycomb group (PcG) proteins and other components in regulating nuclear organization and epigenetic inheritance of chromatin states. The present project conjugates genetics, epigenomics, imaging and molecular biology to reach three critical aims. Aim 1: Analysis of the molecular mechanisms regulating Polycomb-mediated TEI. We will identify the DNA, protein and RNA components that trigger and maintain transgenerational chromatin inheritance as well as their mechanisms of action. Aim 2: Role of 3D genome organization in the regulation of TEI. We will analyze the developmental dynamics of TEI-inducing long-range chromatin interactions, identify chromatin components mediating 3D chromatin contacts and characterize their function in the TEI process. Aim 3: Identification of a broader role of TEI during development. TEI might reflect a normal role of PcG components in the transmission of parental chromatin onto the next embryonic generation. We will explore this possibility by establishing other TEI paradigms and by relating TEI to the normal PcG function in these systems and in normal development. This research program will unravel the biological significance and the molecular underpinnings of TEI and lead the way towards establishing this area of research into a consolidated scientific discipline.

Keywords: polycomb,3d chromosome organization,chromatin,gene expression,hi c,microscopy,drosophila genetics