Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Structural basis for the coordination of chromosome architecture by condensin complexes (CondStruct)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany,Germany
Call: ERC Consolidator Grant (ERC-2015-CoG, 2015)
Start date: 2016-07-01
End date: 2021-12-31
Duration (months): 66.0
Total project cost (EUR): 1982479.0
EU funding (EUR): 125000.0
Participants: 2
Project status: CLOSED

Chromosomes undergo dramatic changes in their three-dimensional organisation during all aspects of genome function, ranging from the regulation of gene expression during cellular differentiation to chromosome duplication and partitioning over the course of a cell division cycle. The multi-subunit condensin protein complex plays major roles for these changes in DNA topology. Despite its fundamental importance, the mechanisms of condensin’s action are not understood. Here, I propose a comprehensive research program that aims to reveal the elusive mechanisms behind the functions of the condensin complex. We intend to unravel how the condensin complex engages DNA, how this interaction activates large-scale ATPase-dependent conformational rearrangements within the complex, and how condensin eventually encircles chromatin fibres within its ring-shaped architecture. Insights from these mechanistic studies will be invaluable for understanding how networks of condensin-mediated linkages can shape linear DNA helices into higher-order chromosome structures. To achieve this ambitious and timely goal, we will combine an integrative structural biology approach with biochemical and cell biological methods. By applying complementary technologies, including X-ray protein crystallography, electron microscopy, cross-linking mass spectrometry, single molecule fluorescence microscopy and reconstitution experiments, we anticipate to build the first model of the entire condensin complex at near-atomic resolution and explain how dynamic conformational changes confer function. The insights gained from this research program will provide an in-depth mechanistic comprehension of the core molecular machinery that determines the architecture of our genomes and will have major implications for understanding how genomic integrity is affected in various disease conditions.

Keywords: chromosome biology
Design for Resource and Energy efficiency in cerAMic kilns (DREAM)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries
Action type: Research and Innovation actions
Countries involved: Spain,Italy,Germany,Italy,Germany,Italy,United Kingdom,United Kingdom
Call: Industrial furnace design addressing energy efficiency in new and existing furnaces (H2020-SPIRE-2016, 2016)
Start date: 2016-10-01
End date: 2019-09-30
Duration (months): 36.0
Total project cost (EUR): 5076105.0
EU funding (EUR): 5076105.0
Participants: 14
Project status: CLOSED

The DREAM project aims to design, develop and demonstrate a radically improved architecture for ceramic industrial furnaces, characterised by optimised energy consumption, reduced emissions, and lower operating costs compared to currently available technological solutions. This will be obtained by substantially enhancing specific furnace parts (control system, refractories, emissions abatement system) and by adding new modules and sub-systems (CHP unit, heat pipes) to the current furnace architecture. DREAM Specific objectives will be: O1 – To design innovative hardware furnace components improving energy efficiency (biofuel-fed CHP unit, heat pipes, emission abatement system) O2 – To introduce substantial improvements on current hardware-software kiln parts (kiln control tool, refractory materials) O3 – To test the DREAM solutions in a variety of industrial settings (retrofitting and pilot kiln demonstrators) O4 – To pave the way for a full seizure of DREAM related market opportunities (dissemination, exploitation within the ceramic sector and market replication) DREAM will develop and demonstrate technologies enabling a significant advancement in the sustainability of ceramics processes, implementing 5 synergic lines of research and 3 industrial demonstrators, which will act as technological showcases for market deployment. Such approach will enable to advance, in the five lines of research, from TRL4 to TRL6. DREAM will strongly contribute to both the sustainability and competitiveness of the European ceramics and process industries. In particular, the DREAM technologies will earn an overall 20% OPEX and energy consumption reduction for industrial furnaces, with an average investment payback time for end users lower than 3 years. The DREAM coordinator and industrial partners are technology and market leaders in the ceramics equipment field, and this will streamline the translation of the DREAM research results into successful products and services.

Keywords: ceramic kilns,refractory materials,simulation,heat pipes,ceramic tile manufacturing
3DTransducers: Functional 3D Printed Transducer and Sensor Systems (3DTransducers)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2018-07-01
End date: 2019-12-31
Duration (months): 18.0
Total project cost (EUR): 146334.0
EU funding (EUR): 146334.0
Participants: 1
Project status: CLOSED

Sensors are ubiquitous in the modern technological world. From the numerous sensors everyone carries within their smartphone, through the pervasive nature of sensors within human machines, to the oncoming explosion of the “Internet of Things” promising immense interconnected networks of sensor enabled systems in virtually every aspect of human life. Micro-electro-mechanical systems (MEMS) as silicon integrated circuits (ICs) are the base technology for nearly all such sensors. In 2017 the worldwide market for MEMS sensors was valued at 10.3€ Billion up from 8.5€ Billion in 2016. It is forecast to grow to 48.4€ Billion in 2024. The use of MEMS ICs provides large-scale manufacture of very cheap sensors. However, there are also many disadvantages. They do not easily provide for rapid and localised/distributed manufacture and implementation. Prototyping requires multi-user foundry platforms or the availability of local facilities, both of which can be relatively expensive, and time consuming, for short runs of prototypes. There are also limitations to what can be achieved. For example, it is very difficult and expensive to make 3D MEMS silicon structures, and there are many issues with liquid interfacing of such systems. 3D printing to make relatively small structures is not new, and various groups have recently reported functionalized polymers. This project will produce 3D printed transducers using 3D printing techniques from the SASATIN ERC project. The 3D printing arrangement does not rely on specific materials purchased from the printer manufacturer.

Keywords: sensors,3d printing,transducers,internet of things,sound,vibration,magnetic,biomedical
Edu*Select: Developing a Commercial Platform to Deliver Teacher Selection Tools (EduSelect)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: The Human Mind and Its Complexity
Panel description: Cognitive science, psychology, linguistics, theoretical philosophy
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-12-01
End date: 2021-05-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Teacher selection presents a significant international challenge: UNESCO predicts that countries will need to select and train almost 69 million teachers by 2030 (UNESCO 2016). However, current teacher selection methods are largely ineffective (Goldhaber et al., 2014; Klassen & Kim, 2019), resulting in the suboptimal quality of the teacher workforce. Improving the ways in which prospective teachers are selected benefits children’s educational outcomes and a country’s social and economic health (Chetty et al., 2014). Our ERC-funded research (2015-2020) represents the first large-scale project to systematically develop and test a suite of selection tools using models from organisational psychology and medical education. Our results suggest that using innovative tools that are built on sound theory and research (especially using a situational judgment test [SJT] methodology) can reliably and validly assess the difficult-to-measure non-cognitive attributes of prospective teachers in multiple contexts (e.g., Klassen & Kim, 2018; Klassen & Rushby, 2019; Klassen et al., 2017; Durksen & Klassen, 2018). The goal of Edu*Select is to explore various commercial platforms (e.g., spin-out company, other start-up, licensing arrangement) from which to leverage our teacher selection research into widespread international application. The short-term impact of the proposal will be to establish the viability of commercial platforms from which to improve the ways in which education organisations (initial teacher education [ITE] programs and potential employers) can gather and use data to make decisions about selecting prospective teachers. The longer-term impact is the improvement of the quality of the teacher workforce, leading to social and economic benefits through enhanced educational outcomes. The ERC PoC project Edu*Select will lead to the market introduction of the first research-led teacher selection tools for international use.

Keywords: education,teaching,personnel recruitment and selection,teacher education,organisational psychology
Revolutionary nano coatings, for enhanced heat transfer in heating and cooling applications (NanoFLUX)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2020-01-01
End date: 2020-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Heat exchangers are core components of many energy intensive applications in heating and cooling. They have not benefited from much improvement in performance for many decades. However, European legislation to limit greenhouse gas emissions and the prospect of bans on refrigerants (and the side effect of rising refrigerant prices) is driving change. Oxford nanoSystems is uniquely positioned to help manufacturers and system integrators meet the ambitious timetable of regulations, while saving them money and resources. Oxford NanoSystems has devised NanoFLUX, a novel process for the application of nanostructured heat transfer coatings, which greatly improves the efficiency of heat exchangers. Heat exchangers, and by extension systems such as air conditioning or refrigeration units, are made more efficient (-40% energy), more compact (-50% size and weight), with and require -70% less refrigerant – which both cuts costs and reducing greenhouse gas emissions. The cost effective NanoFLUX process treats pre-manufactured components, so the innovation can be easily integrated into existing volume plant lines with low upfront investment, achieving scale quickly. The company aims to penetrate a servicable market of over €2.2bn, within an overall €26bn heat exchanger market, growing at CAGR 8.2%. The innovation has already gained significant market interest: NanoFLUX has achieved step-change improvements in tests on the most efficient devices of manufacturers such as SWEP and Alfa Laval. The team includes experienced entrepreneurs, first class engineers, and decades of commercial experience in heat transfer industries. Oxford NanoSystems aims to build from existing R&D revenues, reaching scale commercial contracts by 2021, achieving €30 million revenue and over 200 job creation by 2024. It will contribute to boosting the declining EU leadership position in sustainable and innovative heat transfer technologies.

Keywords: smart coatings,heat exchanger,heating,cooling,efficient heat transfer,energy efficiency
Towards outstanding research and training in tumour biology at IMM (ReTuBi)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,France,Portugal
Call: Twinning (H2020-TWINN-2015, 2015)
Start date: 2016-01-01
End date: 2018-12-31
Duration (months): 36.0
Total project cost (EUR): 999975.0
EU funding (EUR): 999975.0
Participants: 3
Project status: CLOSED

Cancer is a major societal health issue in Europe. In 2012, cancer accounted for around 1.3 million deaths and an estimated economic impact of around € 126 billion in the European Union (EU). The Instituto de Medicina Molecular (IMM) aims to fight this destructive disease by reinforcing its capacity for outstanding pre-clinical and translation research, and by creating a dynamic cluster of excellence within the Lisbon region in the field of cancer research. Towards this goal, IMM is building up a network for outstanding research and innovation with two leading research institutes, the Institut Curie (the largest European cancer research centre), and the DFKZ - Deutsches Krebsforschungszentrum (the largest cancer research institute in Germany), the ReTuBi consortium. ReTuBi targets 4 specific scientific areas: Cancer Stem Cells; Cancer Signalling; Cancer Invasion and Metastasis; and Tumour Angiogenesis. ReTuBi is designed to stimulate the establishment of novel and long-lasting interactions between groups at IMM, Institut Curie and DFKZ. The dynamic and intensive research framework is focused on promoting the exchange of know-how in research excellence and cutting-edge technologies to tackle current and future challenges in tumour biology. Through this initiative, ReTuBi expects an increase of 30% in multiple indicators until 2020, including the number of citations per publication; h-index of IMM researchers; percentage of publications in top 10% impact journals; number of filed patents; and number of international collaborative projects. ReTuBi will also have an impact in the entire IMM community and Lisbon area, through organisation of open scientific meetings, summer schools, and workshops. ReTuBi extensive dynamic network of interactions will provide a channel of knowledge transfer to potentiate already existent scientific and innovative capacity within IMM, promoting an overall increase in competitiveness of Portugal and EU.

Keywords: tumour biology,training and research innovation,cluster of research excellence,long lasting international collaborations,research capacity building
Structure of a large non-crystalline multiprotein assembly by solid-state nuclear magnetic resonance with ultra-fast magic-angle spinning (COMPLEX-fastMAS-NMR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2016-01-01
End date: 2018-01-18
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Extrapolating from protein structure to function is an operation difficult to accomplish, as most functions in the cell are not carried out by single proteins, but by macromolecular complexes containing multiple subunits endowed with specific functions. Despite the many advances in structural and biochemical studies of isolated molecules, a comprehensive portrait of cell biochemistry must thus include insights of the supramolecular network of interactions among the individual constituents. The structure determination of large and dynamical protein ensembles presents a great deal of challenges for X-ray diffraction techniques, and for solution nuclear magnetic resonance (NMR) due to the large size of these objects. Consequently, there is little information available today on the overall organization of the assembly subunits, their interactions, and sometimes their precise function within the cell. High-resolution solid-state NMR (ssNMR) has recently developed as a powerful structural tool for studying structure and dynamics of solid biological samples at atomic resolution. A number of issues remain however to be addressed before ssNMR is ready to cope with large-sized multi-domain functional assemblies. The proposed project aims to capitalize on new concepts recently introduced by the host institution, to implement innovative solid-state NMR methodologies. Sophisticated experimental approaches will be introduced at high magnetic field, in combination with ultra-fast magic angle spinning (MAS), enabling the structure characterization of non-crystalline assemblies that cannot be currently carried out by any other experimental technique, and notably, the determination at atomic level of the structural details that govern protein-protein interactions in functional assemblies. As a benchmark, we will tackle the interaction mode of the ring-shaped hexameric DnaB helicase with its partner DnaC, an assembly that controls the origin of the DNA replication in E. coli.

Keywords: solid state nmr,magic angle spinning,structure determination,e coli replisome,protein protein interactions,dna replication
Enhancing Innovation Management Capacities and Key Account Management (KAM) services for Greek SMEs (Enhancement SGA2)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Greece,Greece,Greece,Greece,Greece,Greece,Greece,Greece
Call: H2020 2D CONSULTATION EEN (H2020-EEN-SGA2-2017-2018, 2016)
Start date: 2017-01-01
End date: 2018-12-31
Duration (months): 24.0
Total project cost (EUR): 136377.09
EU funding (EUR): 136376.89
Participants: 13
Project status: CLOSED

The need for supporting innovation-driven entrepreneurship in Europe as a vehicle for boosting its competitiveness and growth has been evidenced and adopted as one of the key targets and priorities of EU policy and initiatives for the coming years (The Global Competitiveness Report 2013-2014, 2014, WEF). Statistics show that only 50% of EU SMEs innovate and that only a fraction of those export, whereas one of the reasons identified in this respect is constraints relating to innovation management capacity (Regional policy for smart growth of SMEs, 2013, EC). Innovative SMEs have been already identified as one of the groups which EU funding tools should support, however the majority of EU SMEs still lag behind in innovation capacity and innovation management capacity skills. As expected, the above are applicable at a superlative degree to Greek SMEs, for which the 2013 SBA Fact Sheet clearly shows relevant bottlenecks such as e.g. deterioration in their capacity to convert new-to-market and new-to-firm innovations into sales. Under this frame, the Enterprise Europe Network-Hellas (FPA 671771), a well-placed and experienced network of experts and organisations, working in close proximity to Greek SMEs, will advance its support to the innovative companies by providing complementary services for the enhancement of their innovation management capacity. The proposed action aims to: •Identify SMEs with the capacity to innovate and internationalise, provide them with the tailored services to improve their capacity to manage innovation processes •Support SMEs to utilize the opportunities offered under the SME Instrument programme •Support business innovators with international ambitions to translate their ideas into market success •Foster the innovation potential of SMEs that, compared to large companies, have limited capacity for risky/costly R&D activities and consulting services •Offer targeted assistance on innovation management that is not available to Greek SMEs.

Keywords: innovation management,sme instrument
Large Surface Heating and Cooling Element (Large enHANCEMENT)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Germany
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2017-01-01
End date: 2017-06-30
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

More than 15% of CO2 emissions in Europe result from space heatings in buildings. An energy-efficient heat and cold supply on the basis of renewable energy is one of the greatest challenges for our society. The use of geothermal energy or solar thermal energy is a good solution for energy savings and the reduction of greenhouse emissions. Both technologies could not yet establish well on the market because of the lack of inexpensive and efficient low-temperature heating systems (flow temperature 20-30°C). Established underfloor heatings are very expensive and only installed in new buildings. Therefore the market is looking for new and innovative renewable solutions, especially for the renovation. In order to meet this demand we have developed a new surface heating and cooling element (FHKE/TRL6). Objective of the SME Phase 1 project is the implementation of a feasibility study. The new developed heating and cooling panel shall enable a large scale application of low-temperature heating systems. Our element is characterized by the following advantages and therefore perfectly fits the requirements of our target customers (e.g. municipal companies, public estate administration offices, private owners of houses): -reduced heating costs by at least 20% -low costs per m² -rapid mounting -nearly no dust or dirt at renovation -small mass – easy handling, low transport costs -efficient and even heat distribution The current market volume for low-temperature heating system amounts to 500 – 1,000 million Euros. On the basis of imputed assumptions that within the next 15 years about 50% of the nearly 218 million European households need to be energetically redeveloped, this amounts to a market potential of at least 100 billion Euros related to sales. The project „Large enHANCEMENT“ is an integral part of the company’s strategy of Freitec and will lead to significant increase in turnover and employees and in the long-term to a CO2 reduced heat supply in Europe and worldwide.

Keywords: large surface low temperature heating and cooling systems,efficient heating with renewable energy