Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Arctic Cross-Copernicus forecast products for sea Ice and iceBERGs (ACCIBERG)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Space
Destination: Open Strategic Autonomy in Developing, Deploying and Using Global Space-Based Infrastructures, Services, Applications and Data
Action type: Research and Innovation actions
Countries involved: Norway,France,United Kingdom,Italy,Türkiye,Denmark
Call: Copernicus evolution for cross-services thematic domains (HORIZON-CL4-2021-SPACE-01, 2021)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 2999315.0
EU funding (EUR): 2999315.0
Participants: 7
Project status: SIGNED

Sea ice and icebergs are a major security risk for navigation and fisheries in Arctic waters. Both will remain a significant threat even in a warmer Arctic, where traffic is expected to increase. Sea Ice Services are needed more and more to support less experienced captains with automated high quality forecasts and new information about icebergs that are not available today. To monitor and forecast sea ice types and icebergs ahead of time, adequate forecasts of sea ice, ocean, wind, and wave conditions for the whole Arctic are crucial. The Copernicus Marine and Climate Change Services provide such information products. However their uncertainties are not provided in a consistent and user-friendly manner. Reliable uncertainty estimates can however be based on forecast ensembles across the two Copernicus Services. ACCIBERG will improve the quality of sea ice, and ocean products and their uncertainty estimates in both Copernicus Services. It will also extend the coverage of the satellite detection of icebergs and develop a completely new iceberg forecast service. ACCIBERG will build upon state of the art sea ice and ocean models, remote sensing algorithms, data assimilation and cloud computing to offer probabilistic sea ice and iceberg forecasts based on Copernicus data consistently. National or commercial sea ice services are limited to smaller regions and will benefit from the increased accuracy and consistency across the Copernicus products. The new forecasts will be demonstrated in ACCIBERG by European Ice Services and ships of opportunity. The new iceberg forecasts will be automated and validated, and benefit a wide range of user groups navigating in the Arctic, from fisheries to cruise tourism, including Marine Surveillance under the Copernicus Security Service. We will provide prototype products ready to be implemented in the Copernicus services and accessible from a single entry point: its inherent cloud computing solution.

Keywords: arctic,sea ice,icebergs,forecasting,cross copernicus services
4D scanning transmission electron microscopy for structural biology (4D-BioSTEM)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Synergy grants
Action type: ERC actions
Countries involved: Germany,Switzerland
Call: ERC Synergy Grants (ERC-2023-SyG, 2023)
Start date: 2024-01-01
End date: 2029-12-31
Duration (months): 72.0
Total project cost (EUR): 7489397.0
EU funding (EUR): 7489397.0
Participants: 3
Project status: SIGNED

Electron Microscopy (EM) has transformed research in the Life and Physical Sciences separately. Cryo-EM in Life Sciences allows the 3D structure determination of proteins down to 1.0 Å resolution in case they are large enough and present in high numbers in homogeneous states. For many molecules involved in diseases like neurodegeneration, however, structure determination is still severely hampered due to their insufficient contrast when imaged in vitreous ice or in their native cellular environment. To date, EM in the Physical Sciences generated utmost contrast for light atoms and established a resolution in the range of 0.2 Å limited only by thermal motion. This record was achieved by evolving scanning transmission EM (STEM) from a 2D to a 4D imaging technique combining imaging with diffraction. In this project, we will work out 4D-BioSTEM methodologies and develop a cryo-EM tool that maximizes contrast and resolution by bringing together EM groups from Life and Physical Sciences. 4D-STEM imaging of frozen biological specimens will be approached with unique and specialized hardware, theory and simulation, the development of microscope operation routines, and image reconstruction algorithms. In particular, we will acquire sparse 4D data using ultrafast detectors, employ methods for direct phasing (differential phase contrast, DPC) and establish advanced, so-called ptychographic, techniques to gain maximal signal from noisy 4D cryo-STEM data that are limited in their electron dose budget. We will make use of synergies between recently separated fields in order to make proteins smaller than 50 kDa amenable to structure elucidation. Furthermore, we will expand 4D-STEM to tomography, to obtain high-contrast 3D reconstructions from cellular samples, human brain tissue of neurodegenerative diseases, and vitrified organic energy materials. A new comprehensive structural imaging framework will be put forward and benchmarked as to its utility in Life and Physical Science applications of cryo-EM.

Keywords: electron microscopy,cryo em,stem,scanning transmission electron microscopy,phase contrast imaging,image processing,automation,imaging neurodegeneration
Interregional Deeptech and Photonics Support Network for Manufacturing (Deepsupport)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Interconnected Innovation Ecosystems
Destination: Interconnected Innovation Ecosystems
Action type: Coordination and support actions
Countries involved: Austria,Hungary,Italy,Finland,Slovenia
Call: Preparatory action for setting up joint programmes among innovation ecosystems actors (HORIZON-EIE-2023-CONNECT-01, 2023)
Start date: 2024-01-01
End date: 2024-12-31
Duration (months): 12.0
Total project cost (EUR): 518298.99
EU funding (EUR): 497566.85
Participants: 6
Project status: CLOSED

In recent years the manufacturing sector has been one of the stable pillars of European economic growth and therefore prosperity. Photonics, as one of the advanced technologies for industry identified by the European Union, is a relevant deep technology that plays a key role in supporting and innovating the manufacturing ecosystem. On the European landscape several initiatives exist that facilitate cooperation on Photonics, ranging from the public private partnership Photonics21, to European wide clusters like EPIC association and the Digital innovation hub Photonhub Europe. However, they focus mainly on support for individual organisations and while there is also the S3 platform partnership on Photonics, there is no support available to coordinate interregional cooperation in deeptech with the focus on Photonics for manufacturing. Goal of the project is the establishment of an interregional deeptech innovation support network for manufacturing with the focus on Photonics. Output will be a joint supra-regional strategy with best-practice measures for the use of Deeptech/Photonics to support European missions and company competitiveness. This strategy will be co-developed by relevant regional stakeholders from the government body, research, industry and makers communities and include tangible steps to use the complementarities and cooperation potential of the regions to ensure cross-fertilisation.
Illuminating Ice Dynamics with Emerging Seismic Technology (IceDEST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Earth System Science
Panel description: Physical geography, geo logy, geophysics, atmospheric sciences, oceanography, climatology, cryology, ecology, global environmental change, biogeochemical cycles, natural resources management
Countries involved: Switzerland
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-04-01
End date: 2031-03-31
Duration (months): 60.0
Total project cost (EUR): 1921250.0
EU funding (EUR): 1921250.0
Participants: 1
Project status: SIGNED

Sea-level rise (SLR) is one of the greatest challenges facing society this century. By 2050, one billion people will be exposed to extreme sea-level rise events. However, how much and how fast sea-levels will rise remains highly uncertain. Much of this uncertainty arises from a lack of observational constraint of ice dynamics models used to estimate future ice loss. Ice dynamics models are sophisticated and satellite-derived surface observations are readily available, but subsurface friction and fracture observational voids remain. I will address this knowledge gap using seismology, one of the few tools that can illuminate the subsurface. I will harness revolutionary emerging technology (fibreoptic sensing and nodes) to interrogate two critical glacier processes (basal slip and hydrofracture) in unprecedented detail. Basal slip dominates accepted uncertainty in SLR projections, while hydrofracture could accelerate SLR far beyond current estimates. Both processes generate seismic energy that can be directly interrogated. I will develop a new seismic source inversion method that harnesses far denser sampling from fibreoptic sensing and nodes to illuminate the physics controlling glacier slip and hydrofracture. This advance will provide new insights, including: (1) direct measurements of ice-bed interface strength, an essential under- constrained model boundary condition; and (2) quantifying ice fracture stress state and extent, essential for assessing whether hydrofracture is as important as hypothesised for accelerating SLR. Excitingly, ice is seismically simpler than rock, so it also provides an ideal testbed for developing new methods. I will capitalise on this to not only realise glaciology impacts, but also simultaneously realise a fundamental step-change in seismology: laying foundations for mechanistic local noise source inversion. This will pave the way both for noise removal (akin to noise-cancelling headphones) and new ways of imaging the subsurface.

Keywords: seismology,cryosphere,glaciology,geophysical inversion
Development and commercialization of a kit for profiling enzyme activity in liquid biopsies (PTMActKit)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC PROOF OF CONCEPT GRANTS1 (ERC-2022-POC1, 2022)
Start date: 2022-07-01
End date: 2023-12-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Ubiquitination is a post-translational modification (PTM) that is critical for numerous biological processes, including cell cycle, autoimmunity, immune responses, and cancer. This has instigated vast interest in targeting the ubiquitin machinery, and in elucidating ubiquitin-dependent events in pathologies. However, a key constraint is the lack of high-throughput methodologies for monitoring ubiquitination in clinical samples. Current tools mostly provide a qualitative sense of ubiquitin substrates and are limited by the need for unique expertise and large amounts of biological material. To address this gap, we have established a PTM-profiling tool that utilizes enzymatic activity in biological samples (e.g. liquid biopsies), enabling readouts of several PTMs, across thousands of proteins, for multiple samples simultaneously. We will employ our platform technology to the discovery and development of ubiquitin-related diagnostics and therapeutic agents in the field of autoimmunity.
Fully automated label-free bio-sensing technology for drug discovery (DRUGSENSE)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Other destinations
Action type: EIC actions
Countries involved: Sweden
Call: EIC Accelerator 2024 - Short application (HORIZON-EIC-2024-ACCELERATOR-01, 2024)
Duration (months): 18.0
Total project cost (EUR): 8490000.0
EU funding (EUR): 8490000.0
Participants: 1
Project status: SIGNED

InSingulo is a Swedish life science company founded in 2017 following a five-year research collaboration between Chalmers University and AstraZeneca. InSingulo provides the most sensitive label-free biosensing technology for drug development, diagnostics, and quality control. We invented a unique, single-molecule microscopy-based method for biophysical interaction analysis of drug candidates with their targets. Our proprietary solution, dISA (dynamic Inhibition in Solution Assay), allows us to validate potential drug candidates at an early stage of the drug development process, eliminating unnecessary sendings. The setup combines an optical biosensor with automated liquid handling, and the assay takes minutes to complete. In contrast to conventional biophysical methods, InSingulo’s patented technology allows keeping membrane proteins in their native environment, which is a key driver of successful early-stage drug development.

Keywords: single molecule microscopy,drug discovery,biophysics,early drug development,membrane proteins,label free technology,optical biosensor,health related biotechnology
The InDx CMC Implant. A new treatment for thumb base joint arthritis. (InDx CMC Implant)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator Open (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2022-11-01
End date: 2024-04-30
Duration (months): 18.0
Total project cost (EUR): 3658337.5
EU funding (EUR): 2500000.0
Participants: 1
Project status: CLOSED

The InDx CMC Implant is for the treatment of thumb base joint arthritis. It is the first evidence-based, surgeon-led innovation, implant solution for this major clinical problem. The potential market is estimated at over €700M per year. The implant meets a major unmet clinical need for an ageing EU population. The implant re-creates the natural joint biomechanics to give a more reliable and clinically superior outcome for patients. This disruptive technology can change the treatment landscape for this condition. The implant provides an exciting new treatment option for an under-served population. It has been shown to eliminate pain and restore full joint mobility. The InDx Implant is smarter, safer, and simpler to insert than any current treatment options. The InDx Implant is patented, with a clear pathway to regulatory clearance in the EU and US. The company is led by a physician-innovator and is supported by medical device industry veterans and world-leading hand surgeons.
MetAbolomics in pRecision Childhood nutritiOn: a way for precision nutrition? (MARCO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-07-10
End date: 2024-10-09
Duration (months): 15.0
Total project cost (EUR): 113220.6
EU funding (EUR): 113220.6
Participants: 1
Project status: CLOSED

The high prevalence of childhood obesity in several parts of the world indicates a worrying future health scenario, making prevention a high priority. This prevention should focus on diet and physical activity. Regarding food, the beginning of establishing eating habits and preferences occurs in childhood, being necessary that this prevention and treatment is individualized. In this context, precision nutrition offers a new paradigm for health, where the focus is to prevention and treatment strategies based on an individual's unique characteristics. Metabolomics (which is in the omics group - transcriptomics, genomics and proteomics) is being considered an important aspect in precision nutrition, reflecting more realistically effect of food on health and disease. Therefore, the aim of this project is to identify, the metabolomic profile in children aged 3-6 years, and through a longitudinal intervention, if eating behaviour and physical inactivity modify the profile of metabolites that can lead to obesity. The data for this proposal will be derived from a multicenter, parallel, randomized and controlled clinical trial that will be carried out with a cohort of children, followed initially by one year of intervention, with the intention of 10 years in total. The intervention will be based on healthy eating and physical activity. Metabolomics data, anthropometric, dietary, socioeconomic, behavioural, metabolic, biochemical and food environment variables will be collected. Similar studies to this are not available in the literature, and have the potential to increase knowledge about nutritional metabolomics, especially in early childhood and serve as a database for other studies with this population. This can reduce childhood obesity, minimize nutritional and metabolic risks in childhood and reduce the economic, environmental and social impact this disease.

Keywords: early childhood precision nutrition
Palestinian youth at the crossroad: comparative perspectives on Palestinian transnational youth politics (PYC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,United States
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-07-15
End date: 2026-07-14
Duration (months): 36.0
Total project cost (EUR): 288859.2
EU funding (EUR): 288859.2
Participants: 2
Project status: SIGNED

This research project explores the political potential of contemporary Palestinian transnational youth activism in the United States and Europe. It compares student political engagement namely by examining the formation and development of the General Union of Palestinian Students (GUPS) during what is regarded as the “golden age” of the Palestinian revolution (1960s-1970s) with contemporary initiatives, efforts and strategies of mobilization amongst Palestinian youth in Diaspora. By implementing both cross-generational and transnational comparative frameworks, this project provides a comprehensive mapping of youth and student experiences in the U.S. and Europe in order to evaluate what kind of initiatives are emerging and what capacity they hold in re-structuring the Palestinian national movement. By looking to the past through a historical continuum that has molded present day Palestinian youth activism, this project proposes that new futures can only be made through methodologies that tether together time and space. How have Palestinian new generations responded to the political transformations that have informed the Palestinian as well as the regional and international scenarios? Is there space for Palestinian youth to contribute to the revitalization of a paralyzed national movement, within a transnational framework able to appreciate the diverse socio-political, economic and cultural backgrounds that characterize contemporary Palestinian society? This project address these questions by providing a comparative analysis of two different political moments of Palestinian history, the pre-Oslo and the post Oslo periods. This comparison allows the understanding of how youth politics has evolved over time and across space and what mechanisms can or cannot be reproduced within the broader Palestinian political context. In doing so, the study will allow new, empirically-based, deductions on the general state of Palestinian politics and its future perspectives

Keywords: palestine,transnational movements,anti colonial movements,diaspora,middle east studies
Multilingual and Cross-cultural interactions for context-aware, and bias-controlled dialogue systems for safety-critical applications (ELOQUENCE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Partnership: AI-DATA-ROBOTICS (co-programmed)
Countries involved: Slovenia,Cyprus,Greece,Switzerland,United Kingdom,Italy,Spain,Serbia,Czechia,France
Call: Natural Language Understanding and Interaction in Advanced Language Technologies (AI Data and Robotics Partnership) (RIA) (HORIZON-CL4-2023-HUMAN-01-CNECT, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 5072543.75
EU funding (EUR): 5072543.75
Participants: 16
Project status: SIGNED

ELOQUENCE is focused on the research and development of innovative technologies for collaborative voice/chat bots. Voice assistant-powered dialogue engines have previously been deployed in a number of commercial and governmental technological pipelines, with a diverse level of complexity. In our concept, such a complexity can be understood as a problem of analysing unstructured dialogues. ELOQUENCE’s key objective is to better comprehend those unstructured dialogues and translate them into explainable, safe, knowledge-grounded, trustworthy and bias-controlled language models. We envision to develop a technology capable of learning by its own, by adapting from a very data-limited corpora to efficiently support most of the EU languages; from a sustainable computational framework to efficient and green-power architectures and, in essence, that may serve as a guidance for all European citizens whilst being respectful and showing the best of our European values, specifically supporting safety-critical applications by involving humans-in-the-loop. Overall, ELOQUENCE’s project considers building on top and to improve of prior achievements in the domain of conversational agents, e.g. recently launched and public-domain Large Language Models (LLMs), such as chatGPT (e.g., more recent versions), or LaMDa most of them developed in non-EU countries. While including key industrial enterprises from Europe (i.e., Omilia, Telefonica, Synelixis), ELOQUENCE will validate the developed technology through (i) safety-critical scenarios with human-in-the-loop for security-critical applications (i.e., emergency services in call centres) and (ii) smart home assistants via information retrieval and fact-checking against an online knowledge base for lesser risky autonomous systems (i.e., home-assistants). ELOQUENCE will target the R&D of these novel conversational AI technologies in multilingual and multimodal environments and demonstrated in several pilots.

Keywords: distributed and federated adaptation of large language models,multiliinguality,multimodality,human in the loop,bias mitigation,grounding