Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Evolution and success of the multi-drug resistant M. tuberculosis SIT41 (LAM7-TUR) lineage (MDR Tuberculosis)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Career Restart panel
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-10-01
End date: 2017-09-30
Duration (months): 24.0
Total project cost (EUR): 185076.0
EU funding (EUR): 185076.0
Participants: 1
Project status: CLOSED

Mycobacterium tuberculosis (MTB) is the cause of tuberculosis (TB) in humans. Identification of the MTB lineage is of importance to tuberculosis control as it has shown that strain type may play a role in disease outcome, variation in vaccine efficacy and emergence of drug resistance. MTB strains of Beijing and Latin-American-Mediterranean (LAM) lineages were associated with hyper-transmissibility and drug resistance. In 2013 the European Center for Diseases Prevention and Control (ECDC) effectively lunched molecular surveillance of MDR TB at EU level. The typing of M. tuberculosis strains in Bulgaria confirmed strong association between MDR and SIT41 (LAM7-TUR) [SIT – Spoligo International Type] MTB lineage. Statistically 97% of the TB patients infected with drug sensitive SIT41 MTB strain develop MDR tuberculosis. SIT41 is marker genotype for MDR TB. Urgent measures are needed to control and limit the expansion of the SIT41 lineage. We aim to promote personalised treatment of tuberculosis based on the genotype lineage of the TB pathogen and reducing the TB multidrug-resistant burden. The project has two objectives. First: Application of the next-generation sequencing data for genotyping of M. tuberculosis strains based on SNP data for tracking the origins, evolution and success of the SIT41 (LAM7-TUR) lineage, and second: Development of rapid screening methodology to identify the SIT41 (LAM7-TUR) genotype including mutation analysis to first and second line tuberculostatics drug resistance. Objectives will be achieved by fostering radically new technologies, by exploring novel ideas for MTB genotyping and improvement of the classical TB treatment scheme. The project is timely because it has relevance to the Work Program Horizon 2020 focus area: Personalising health and care. For the first time we will promote personalised treatment associated with specific MTB genotype. The proposal is in line with the EU Health Strategy, ECDC, WHO and other TB control programs.

Keywords: multidrug resistant tuberculosis,genotype,lineage,mycobacterium tuberculosis,tuberculosis,mdr tb
High grade PROteins innovatively processed into VEGetal FLAKEs from plant sources with enhanced nutritional benefits (ProVegFlake)

Framework: Horizon 2020 — Societal Challenges
Programme: Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy
Action type: SME instrument
Countries involved: Germany
Call: Resource-efficient eco-innovative food production and processing (H2020-SMEINST-1-2015, 2015)
Start date: 2016-03-01
End date: 2016-08-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Most people require about 0.8 g of protein/kg of body weight, or about 58 g of protein/day for a 72 kg adult. Vegetarians and vegans need to eat 10–20% more protein than recommended for compensating the lower digestibility of plant-based protein. IGV will upgrade the protein-rich production in its modern Technological Centre from a current TRL6-7 to TRL9 level. This will be achieved by optimising an innovative combination of extraction and extrusion, which will broaden the European market penetration of our plant-based proteins. Following sustainability aspects of global emerging markets the main application is to upgrade the production of essential aminoacids (EAAs)-enriched, non-soy, gluten- and GMO-free peabased protein flakes and supply them as innovative alternative components to the breakfast cereals, meat surrogates and health-value drinks industries. The products will be produced for a special market: existing and new customers of finished healthy, vegan/vegetarian products for athletes, sportsmen. Our preliminary calculations prove that optimising and upgrading our production capacity will close the gap between the small- and large-scale markets, supporting also other industrial and SME organisations for sustainable growth. The production will be during the first 3 years in one working shift and from year 4 in two working shifts, generating 6-8 new FTEs. This will be detailed in a realistic Business Plan and Commercialisation Strategy in Phase 2. Maximising impact of our products will mean professional Product Management, Marketing and PR, including product and promotional material design, distribution, press-releases, videos, newsletters and articles. Market penetration of our vegetal proteins will be facilitated by thematic workshops, application trials with farmers, food processors, consumers. We intend besides penetrating niche markets, also to extend our market share with support of Coaching Actions, own resources and Venture Capital of EU as well.

Keywords: innovative,vegetal,protein flakes,extraction,extrusion,market penetration,vegan,vegetarian,coaching
HOminin Proteomes in human Evolution (HOPE)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Denmark
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 200194.8
EU funding (EUR): 200194.8
Participants: 1
Project status: CLOSED

This project aims to reconstruct the genetic relationships between our and extinct hominin species from sites and time periods incompatible with ancient DNA preservation through mass-spectrometry based sequencing of ancient hominin proteins. Understanding the evolutionary relationships between extinct and extant hominins is a major goal of palaeoanthropology, including insights into population dynamics and traits selected for/against in particular hominin lineages. Up to recently this was exclusively achieved through ancient DNA analysis. Ancient DNA survives for a limited amount of time, however, and is commonly degraded entirely after 0.5 or 1.0 Ma. A new biomolecular approach to this issue is the analysis of ancient proteins preserved in enamel, dentine and bone from hominin fossils, as recent studies demonstrate that ancient proteins survive for longer stretches of time than DNA. HOPE will advance these developments by applying novel methodological approaches to the extraction and characterization of hominin ancient proteins in samples beyond the survival of ancient DNA. Specific objectives are 1) to test proposed evolutionary hypotheses on hominin evolution through the characterization of ancient enamel protein sequences from a number of extinct hominin populations of significant age, 2) to increase non-collagenous protein sequence recovery from dentine samples, 3) to explore the population proteomic potential of hominin proteomes, and 4) to understand changes in enamel proteome composition throughout hominid evolution. These objectives will be realized by analysing hominin specimens from a range of taxonomic clades present in the Early, Middle and Late Pleistocene of Africa and Eurasia. HOPE thereby provides novel interdisciplinary insights into human evolution and methodological tools of use across palaeonthropology and evolutionary biology.

Keywords: ancient proteins,human evolution
2shRNA branched nanobinders as promising therapeutic tools for combined cancer therapy (2shRNA)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: Spain
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

This project aims to optimize and validate a promising therapeutic tool for combined cancer therapy, 2shRNA, in an ex vivo model system. Combined therapies are of great significance nowadays, due to their key role in fighting, for instances, resistance processes during cancer treatment. Nonetheless, the drug combinations approved to date face several problems, such as cooperative toxicity effects, lack of efficiency and poor bioavailability. We have designed and synthesized 2shRNA, a new bifunctional RNA tool that can simultaneously attack two therapeutic targets involved in drug resistance pathways, and that can additionally bind other molecules such as peptide carriers or fluorophores, to improve delivery and efficacy. The 2shRNA nanostructure displayed low toxicity and excellent anti-proliferative properties in resistant HER2+ breast cancer cell lines. The present proposal is aimed at optimizing and validating this novel and promising RNA tool by combining state-of-the-art bioinformatics design and cycles of chemical refinement with biological evaluation in PDx-derived primary cell cultures and biodistribution studies in PDx mouse models. The proposed strategy presents a novel therapeutic approach with great potential to circumvent drug resistance in breast cancer, which is a major health challenge for our society. The ability of our biostable RNA tool to administer two drugs in a single dose could improve the quality of life of the patients, as fewer doses might be needed to stall disease progression.

Keywords: combined therapy,breast cancer,bifunctional shrna,network medicine,rna synthesis,biostability,peptide carrier,selective delivery,biological evaluation,ex vivo,pdx derived primary cultures
Inverse boundary problems: toward a unified theory (IPTheoryUnified)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Mathematics
Panel description: All areas of mathematics, pure and applied, plus mathematical foundations of computer science, mathematical physics and statistics
Countries involved: Finland
Call: ERC Consolidator Grant (ERC-2017-COG, 2017)
Start date: 2018-05-01
End date: 2023-10-31
Duration (months): 66.0
Total project cost (EUR): 920880.0
EU funding (EUR): 920880.0
Participants: 1
Project status: SIGNED

This proposal is concerned with the mathematical theory of inverse problems. This is a vibrant research field at the intersection of pure and applied mathematics, drawing techniques from PDE, geometry, and harmonic analysis as well as generating new research questions inspired by applications. Prominent questions include the Calderón problem related to electrical imaging, the Gel'fand problem related to seismic imaging, and geometric inverse problems such as inversion of the geodesic X-ray transform. Recently, exciting new connections between these different topics have begun to emerge in the work of the PI and others, such as - the explicit appearance of the geodesic X-ray transform in the Calderón problem - an unexpected connection between the Calderón and Gel’fand problems involving control theory - pseudo-linearization as a potential unifying principle for reducing nonlinear problems to linear ones - the introduction of microlocal normal forms in inverse problems for PDE These examples strongly suggest that there is a larger picture behind various different inverse problems, which remains to be fully revealed. This project will explore the possibility of a unified theory for several inverse boundary problems. Particular objectives include: 1. The use of normal forms and pseudo-linearization as a unified point of view, including reductions to questions in integral geometry and control theory 2. The solution of integral geometry problems, including the analysis of convex foliations, invertibility of ray transforms, and a systematic Carleman estimate approach to uniqueness results 3. A theory of inverse problems for nonlocal models based on control theory arguments Such a unified theory could have remarkable consequences even in other fields of mathematics, including controllability methods in transport theory, a solution of the boundary rigidity problem in geometry, or a general pseudo-linearization approach for solving nonlinear operator equations.

Keywords: inverse problems,microlocal analysis
IFR RPAS Control in Airports and TMA (INVIRCAT)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (Art-187)
Countries involved: Spain,Italy,Italy,Italy,Germany,Belgium,Netherlands
Call: Control of IFR RPAS in the TMA (H2020-SESAR-2019-2, 2019)
Start date: 2020-07-01
End date: 2022-12-31
Duration (months): 30.0
Total project cost (EUR): 1614613.75
EU funding (EUR): 1416055.0
Participants: 7
Project status: CLOSED

This proposal addresses the topic “Control of RPAS in the TMA” of the H2020 call “SESAR-ER4-28-2019”. Its objective is to provide means for a safe and efficient integration of RPAS (Remotely Piloted Aircraft Systems) into the existing Air Traffic Control (ATC) procedures and infrastructures within Terminal Manoeuvring Areas (TMA) under Instrument Flight Rules (IFR). The main goals of the INVIRCAT project are the creation of a concept of operations for remotely piloted aircraft systems in the terminal manoeuvring area of airports, assessing it through simulations and draft a set of recommendations for rulemakers and standardization bodies. In INVIRCAT a CONOPS will be elaborated for full accommodation of RPAS in TMA environments, including Automatic Take-Off and Landing (ATOL) procedures. These CONOPS will serve as a basis for implementing a cooperative, heterogeneous and distributed simulation infrastructure to enable a full IFR RPAS flight from one airport to another including all phases of flight. Based on the results of the simulations and the validation of the CONOPS a set of high level operational and technical requirements will be defined. To meet the objectives, the INVIRCAT consortium is formed of a balanced group representing the most innovative research arms of the ATM, ATC, UAS, UTM and UAM industries. In addition, a close collaboration with related projects on the topics “SESAR-ER4-29-2019: Remain Well Clear for IFR RPAS Integration in Class D-G Airspace” and “SESAR-ER4-30-2019: RPAS for Manned Flight Contingency Management” will be established, to feed their results into the concept of INVIRCAT. An Advisory Board will be set-up to validate the requirements and to explore the challenges presented by the co-existence of conventional manned aviation, drones and UAM aircraft in aerodrome environments.

Keywords: rpas,rpas integration,rpas guidance
Beta-decay studies with laser-polarised beams of exotic nuclei (BeLaPEx)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Switzerland
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2022-02-01
End date: 2024-01-31
Duration (months): 24.0
Total project cost (EUR): 191149.44
EU funding (EUR): 191149.44
Participants: 1
Project status: SIGNED

The goal of the BeLaPEx project is to study β decay of exotic nuclei relevant to the astrophysical r-process. We will build the first European β-decay spectroscopy station dedicated to measurements with spin-polarised radioactive beams. Our setup, DeVITO, will be coupled to the new beamline for laser-induced nuclear orientation, called Versatile Ion-Polarised Techniques Online (VITO). We will apply a novel technique that utilises anisotropic β decay of spin-polarised nuclei, allowing to firmly assign spins and parities of excited states populated through allowed transitions based on the β-decay asymmetries measured in coincidence with the delayed radiations. The BeLaPEx project will help to clarify the sensitivity of β-delayed neutron emission to the details of nuclear structure. We will provide experimental data that can benchmark nuclear models and improve the understanding of β-delayed neutron emission. The BeLaPEx project will be carried out at the Isotope Mass Separator On-Line facility (ISOLDE) at CERN, where a wide range of radioactive ion beams is available, including those relevant to the r-process. The first part of the project will focus on the construction and commissioning of the DeVITO station allowing for measurements of β-particle, γ-ray and neutron emission from spin-polarised nuclei. Subsequently, we will start the physics program aimed at studying neutron-rich indium isotopes around N=82. These nuclei are important for the r-process calculations since the A=130 peak in the r-process abundance pattern is linked to the closure of the N=82 shell.

Keywords: beta decay,beta delayed neutron emission,neutron rich nuclei,laser polarised beams
FUnerals as public Services in long Eighteenth century London (FuSEL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: United Kingdom
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2016-07-01
End date: 2018-06-30
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

The research aims to understand the organization and functioning of services for the community in early modern London through a concrete case study, namely the ways in which funerals and burials were managed during the long eighteenth century (1670-1852). I selected the case of London in order to complete a long-term comparative study that began with my doctoral research. By extending my research to London, I will be able to compare it with Paris and Naples, which I analysed in my previous research experiences. These three capitals were the most populous cities in Europe during the study period. How did these multifaceted societies solve issues of collective interest before the birth of modern public services? Which elements did modern public services inherit from them? In order to ask to these questions, I will make use of an interdisciplinary methodology taking advantage of expertise acquired at Birkbeck, University of London, under the guidance of an excellent supervisor (Professor Vanessa Harding). Working in a large, many-faceted academic entity such as the University of London will be a considerable milestone in my career. I will acquire a strong comparative methodology that is essential for my long-term research purpose. Furthermore, I will attain important competences in both educational and research policies, as well as a better understanding of administrative issues, in English-speaking countries, which still differ considerably from the countries where I worked until now (Italy and France). Parallel to the program of research and training, I will put in place a series outreach activities that will enable me to engage with a wider public and share the relevance of historical research for an understanding of today’s problems and the development of adequate responses to these by decision-makers and those working in our institutions and society.

Keywords: public services,funerals and burials,london,early modern history,new institutional economics
'Feeling European'. The Visual Construction of EU Identity. (EVI)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Netherlands
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2017-07-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

European Visual Identity - Summary This project uses virtual ethnography and semiotic deconstruction to critically investigate how the formation of a European identity is reliant upon political symbols with which EU citizens can emotionally identify, and suggests directions for reforming the Union’s ‘symbolic capital’1 to encourage greater citizen affiliation with the EU.

Keywords: european identity,political symbols,european iconography,numismatics,eu flag,cartography,monuments,visual identity,political communication
Innovation and opportunity in the evolution of life (INNOVATION)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Environmental Biology, Ecology and Evolution
Panel description: Ecology, biodiversity, environmental change, evolutionary biology, behavioural ecology, microbial ecology, marine biology, ecophysiology, theoretical developments and modelling
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2018-10-01
End date: 2024-09-30
Duration (months): 72.0
Total project cost (EUR): 2482225.0
EU funding (EUR): 2482225.0
Participants: 1
Project status: SIGNED

The aim is to produce a complete evolutionary tree of tetrapods and use this to explore two core questions in macroevolution: the balance between innovation and external processes in driving the evolution of life; and, identifying the best model for morphological evolution. Biodiversity today is unbalanced, with a small number of highly successful groups, like birds and beetles, and many others of equal antiquity but with far fewer species. Why are those groups so successful – was it chance or do they have some remarkable adaptation(s)? The core of the project is to construct a complete evolutionary tree of all 30,000 living species of tetrapods (amphibians, reptiles, birds, mammals) and add the 10,000 fossil species; this will generate a database of key characters, the homologies, shared by major groups. The probability of different drivers of diversification will be tested, focusing on those key, highly successful groups (e.g. lizards, birds, neornithines, passerines, rodents) that show explosive evolution to very high species diversity. The proposal goes to the roots of macroevolutionary understanding, and encompasses key questions about origins and modern biodiversity. The project is ambitious, but is possible because of advances in knowledge of relationships of all key tetrapod groups based on phylogenomic and morphological data, increasing precision of geological dating, and the availability of a range of computational methods to construct large phylogenetic trees, to assess likelihood of trees, to explore innovation and evolutionary rates and models, and Bayesian modelling techniques that can map trait data onto large trees and evaluate multiple models of drivers and bias. A unique outcome will be the chance to explore waiting time between major morphological changes, assessing distribution and magnitude, and use this information to inform the construction of a meaningful model of morphological evolution for computational phylogenetics.

Keywords: macroevolution,drivers of evolution,evolutionary models,mass extinctions,adaptive radiations