Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Structured functional glasses for lasing sensing and health applications (FunctiGlass)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Doctoral Networks
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: France,Finland,Germany,Poland,Italy,Czechia,Kazakhstan,Sweden,Belgium
Call: MSCA Doctoral Networks 2023 (HORIZON-MSCA-2023-DN-01, 2023)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 3560882.4
EU funding (EUR): 3560882.4
Participants: 20
Project status: SIGNED

Over the past four decades, glasses, glass-ceramics and composites have contributed to achieving the most advanced socio-economic breakthroughs steadily as advanced high-tech materials. To highlight the importance of glass, 2022 has been declared International Year of Glass by the United Nations. To compete with emerging economies like China and India, the European glass sector is challenged to seek product leadership by investing more in research and innovation in order to develop new materials and to train specialists for a competitive but promising market. Contributing to this challenge is the main aim of this project “Structured functional glasses for lasing, sensing and health applications” (FunctiGlass), a unique interdisciplinary double-degree research and training program. It aims at impacting advanced high-tech materials for three sectors: Light sources, Sensors and Bio-applications. FunctiGlass program will fully train 11 Doctoral Candidates (DCs) who will participate in a joint research training program built on very strong academia/industry cooperation. It guarantees the exposure of Researchers to 11 academic (universities and research institutes) and 9 non-academic environments (industry and SMEs) representing 9 different countries. Each DC will be supervised by two academic tutors and one mentor (industrial partner) to guarantee inter-sectorial knowledge sharing and acquisition of transferable skills with emphasis on entrepreneurship and innovation. With the multi-dimensional training of FunctiGlass program, the 11 DCs will excel in the future economy by acquiring a multi-faceted perspective and a growing mindset to become the future leaders in glass science and especially in nano/micro-structured glass-based materials. With this program, the DCs will find their own future innovative path in academia or industry. This program will create the grounds for establishing long-term relations between the academic and private sectors for technology and compete

Keywords: glass based materials spectroscopy sensing laser irradiation film optical fiber
integrated urban FOOD policies – developing sustainability Co-benefits, spatial Linkages, social Inclusion and sectoral Connections to transform food systems in city-regions (FOODCLIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Resilient, inclusive, healthy and green rural, coastal and urban communities
Action type: Innovation actions
Countries involved: Netherlands,Denmark,Spain,Hungary,Belgium,Portugal,Germany,South Africa,Romania,Italy,France,United Kingdom
Call: Integrated urban food system policies – how cities and towns can transform food systems for co-benefits (HORIZON-CL6-2021-COMMUNITIES-01, 2021)
Start date: 2022-09-01
End date: 2027-02-28
Duration (months): 54.0
Total project cost (EUR): 11418499.3
EU funding (EUR): 11182035.01
Participants: 28
Project status: SIGNED

Europe’s urban areas face significant challenges to ensure the availability and consumption of healthy, affordable, safe and sustainably produced food. Such challenges converge within local food environments, but are often neglected by public planners. Promising initiatives taken by municipalities to change the architecture of food choice often fail to become embedded in the wider policy context and to reach deprived and vulnerable groups. Key factors responsible for this are: (1) siloed ways of working and (2) fragmentation of knowledge on facilitators and barriers related to food system transformation. These factors hinder the development and implementation of integrated urban food policies. FOODCLIC will create strong science-policy-practice interfaces across eight European city-regions (45 towns and cities). The backbone of such interfaces will be provided by Food Policy Networks, which will manage real-world experimental Living Labs to build a policy-relevant evidence-base through learning-in-action. Activities will be informed by an innovative conceptual framework (the CLIC), which emphasizes four desired outcomes of food system integration (sustainability co-benefits, spatial linkages, social inclusion and sectoral connectivities). Capacity-building and direct support for intensive multi-stakeholder engagement (including deprived and vulnerable groups) will enable policy actors and urban planners across partner city-regions to develop continuously evolving integrated urban food policies and render planning frameworks food-sensitive. Results will be communicated and disseminated amongst others by extending the novel policy practices to another eight city-regions in Europe and Africa, an online Knowledge-Hub, a high-level Think Tank and partners’ networks. In these ways, FOODCLIC aims to contribute to urban food environments that make healthy and sustainable food available, affordable and attractive to all citizens (including deprived and vulnerable groups).

Keywords: food environments,food policies,planning frameworks,science based and integrated,science policy practice interface,city regions,deprived and vulnerable groups,real life interventions,living labs
Chemical Rewiring of Oncogenic Transcription (geNEOMORPH)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2024-COG, 2024)
Start date: 2025-08-01
End date: 2030-07-31
Duration (months): 60.0
Total project cost (EUR): 1999724.0
EU funding (EUR): 1999724.0
Participants: 1
Project status: SIGNED

Many cancers are driven by mutations affecting transcription regulation. Through cancer genome sequencing studies, we understand that these aberrations are pervasive through many layers of gene control. Yet, with few exceptions, this knowledge has not precipitated in effective treatments since pharmacologic inhibition of transcription is often infeasible or functionally inconsequential. To address this limitation, I want to innovate chemical strategies that move beyond loss of function (LOF) approaches. Gene control is organized at the level of proximity. Hence, I hypothesize that transcriptional regulators can be chemically rewired by neomorphic small molecules that recruit functionally opposing gene-regulatory effectors, thereby prompting an acute, deep, and sustained disruption of oncogenic transcriptional circuits. The identification, characterization, and translation of such Neomorphic Transcriptional Compounds (NeoTraCs) will be the subject of the GE|NEomorph proposal. We will focus on NeoTraCs to rewire the repressive PRC2 complex, the p400 chromatin regulator complex, and the non-canonical BAF complex. While these targets have established roles in various cancers, inhibitors are not available or have limited functional impact. To identify NeoTraCs that address these limitations, we will implement a diverse discovery approach that incorporates hypothesis-driven design with phenotypic strategies geared to co-opt undrugged transcriptional effectors via bivalent NeoTraCs, and unligandable effectors via molecular glue-like NeoTraCs. Identified hits will be characterized via multi-omics approaches. Through careful mechanistic investigation, we will deduce general mechanistic principles, understand their impact on oncogenic transcription and investigate associated translational opportunities. GE|NEomorph will significantly advance our ability to understand and disrupt transcriptional dysregulation in cancer and pave the way for novel innovative therapies.

Keywords: proximity inducing pharmacology,chemical genetics,chemical proteomics,transcription,target identification
Cascades for Stereoselective Synthesis of Amino Acids (cassaFLOW)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Transition
Destination: Open to supporting projects in all areas of science, technology,...
Action type: EIC actions
Countries involved: Netherlands,Sweden,Germany
Call: EIC Transition Open 2023 (HORIZON-EIC-2023-TRANSITION-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 2378694.25
EU funding (EUR): 2378694.25
Participants: 5
Project status: SIGNED

Non-natural amino acids are essential building blocks for pharmaceuticals. The COVID-19 drug Paxlovid is a prime example for this. But as for most pharmaceuticals, the synthesis of these amino acids is complex and requires many steps. This is especially true for amino acids with 2 stereocenters, the focus of this application. Of the group of the 20 most common natural amino acids 2 have not one but two chiral centers: isoleucine and threonine. Non-natural isomers of these 2 amino acids are surprisingly difficult to make and commercially not available via an economically viable process. At the same time they are highly important for the production of drugs like Paxlovid. In cassaFLOW, we will develop a cascade for the stereoselective synthesis of amino acids with 2 stereocenters. Based on the scalable breakthrough technology developed in our previous project ONE-FLOW, we will design cascades of reactions shortening the current syntheses. The main objective is to replace an 8-step stereoselective synthesis of an amino acid with a 3-step cascade to the same amino acid. This will be achieved by installing 2 stereocenters in 1 biocatalytic step and by applying flow technology from the ONE-FLOW project. Here, we will telescope long reaction paths with multiple work up steps into short and clean processes. Our innovative technology builds on ONE-FLOW methodology and will be combined with the reaction engineering and commercial expertise of the two SME’s in cassaFLOW, ChiralVision and SpinChem. The outcome of cassaFLOW will be a 3-step TRL 6 synthesis of an isoleucine that will replace the current 8-step production and can be directly placed on the market. Importantly, the cassaFLOW outcome will contribute to the EU Strategic Autonomy 2013-2023 Plan that aims to achieve a greater independence from delivery chains, and is in line with the “Pharmaceutical Strategy for Europe” that aims to produce pharmaceuticals with short production chains in Europe.

Keywords: cascade reactions,flow chemistry,pharmaceuticals,biocatalysis,stereochemistry
Frozen in time – Unravelling Younger Dryas climate variability, environmental dynamics and their impact on human recolonization in Western Europe (FROST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Study of the Human Past
Panel description: Archaeology and history
Countries involved: Belgium
Call: ERC STARTING GRANTS (ERC-2025-STG, 2025)
Start date: 2026-02-01
End date: 2031-01-31
Duration (months): 60.0
Total project cost (EUR): 1557358.0
EU funding (EUR): 1557358.0
Participants: 1
Project status: SIGNED

The Late Glacial period, at the end of the Pleistocene, is marked by dynamic climatic and environmental changes. During this time, hunter-gatherers gradually recolonized Western Europe after a retreat of several millennia, representing a pivotal phase in the region’s population history. However, during the final climatic cooling of the Late Glacial, known as the Younger Dryas (ca. 12,850 to 11,650 cal BP; YD), the number of archaeological sites drastically reduced, raising questions about population decline, migration, and adaptation to severe environmental stress. Despite its significance, the human responses to these climatic shifts remain poorly understood. The FROST project aims to bridge this gap by investigating the impact of climate fluctuations within the YD on human populations, mobility, subsistence strategies, and the ecosystems they depended on. The project uses a multi-proxy approach, integrating palaeoclimate, palaeoecological, and archaeological data from 30 key sites across Western Europe. This includes high-resolution analysis of speleothems (isotopes, trace elements), pollen, sedaDNA, sediments (granulometry, MS, LOI, micromorphology), and reindeer remains (isotopes) from archaeological sites. These data will be anchored with high-resolution dating using 14C, OSL, U/Th and tephrochronology. FROST tackles four core challenges: (1) reconstructing regional climate variability within the YD, (2) assessing ecosystem responses to these climate shifts, (3) tracking reindeer herd movements, and (4) refining the timing and spatial dynamics of human occupation patterns. By integrating these datasets into demographic and spatiotemporal models, FROST will explore how prehistoric populations adapted to environmental changes. This will not only significantly advance our understanding of human recolonization during a crucial phase in Western Europe, but also provide insights relevant to contemporary climate challenges.

Keywords: geoarchaeology,prehistoric archaeology,younger dryas,final palaeolithic,palaeoenvironmental dynamics,climate change,geochronology,human behaviour,human migration,reindeer migration
Developing a Culture of Whistleblowing and Empirical Examination of Whistleblowing Mechanisms (WHISTLEBLOWING)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Economic Sciences
Countries involved: Türkiye
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 148478.4
EU funding (EUR): 148478.4
Participants: 1
Project status: SIGNED

Whistleblowing is one of the most effective means of exposing and deterring wrongdoing, even though those who blow the whistle on such misconduct are often subjected to social and organizational stigma, despite their vital role in uncovering corruption. They face reprisal, demotion, harassment, and even dismissal from their jobs. As whistleblowers disclose organizational misconduct internally and/or externally to create and sustain a culture of integrity and transparency, organizations must establish effective whistleblowing channels that encourage speaking up without fear of retaliation. This project aims to positively transform perceptions toward whistleblowers through normative ethics training, compare the effectiveness of whistleblowing mechanisms across the world, and develop internal reporting mechanisms that consider the psychology of potential whistleblowers to create a culture of whistleblowing. This project fills significant gaps in examining the psychology behind whistleblowing and moves beyond existing scholarship by integrating global and local perspectives and mechanisms for whistleblowing and connecting business ethics, organizational behavior, and law literature to foster a culture of whistleblowing. Through investigating the psychological perspectives on whistleblowing and integrating the whistleblowing mechanisms in the European Union, the United States, and beyond, the project offers unique opportunities for internal whistleblowing mechanisms in Turkey and Europe.

Keywords: whistleblowing organizational behavior management business ethics
FILTERING FUTURES: CONTAMINANT FLOWS, LANDSCAPE GOVERNANCE AND THE MAKING OF NEW ANTHROPOLOGICAL KNOWLEDGE FOR PLANETARY HEALTH (FILTERSCAPE)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Studies of Cultures and Arts
Panel description: Social anthropology, studies of cultur es, stud ies of arts
Countries involved: Denmark
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2025-12-01
End date: 2030-11-30
Duration (months): 60.0
Total project cost (EUR): 2317071.0
EU funding (EUR): 2317071.0
Participants: 1
Project status: SIGNED

Filtering contaminating flows in water ecologies is a critical problem for planetary health. Current approaches e.g. One Health, favour collaboration among disciplines, governmental bodies, citizens and ecological (more-than-human) actors, to innovate new thinking and sustain interventions. Despite aspirations, efforts to pull human and ecological forces into play remain obstructed by disciplinary silos, vested interests, epistemic uncertainty and a lack of a shared vocabulary. FILTERSCAPE offers a groundbreaking research agenda for anthropology to address these limitations and drive new thinking in planetary health forward. It captures the overlooked human and more-than-human filtering work within water ecologies. Filtration is a mechanism that can mediate, exacerbate and ameliorate environmental contamination. Enacted in the relations between people, organisms and infrastructures, it works to separate and absorb wanted from unwanted matter. In doing so, it interrupts flows of contamination, to reveal their sources, effects and politics. FILTERSCAPE will analyze ecological (wetland), infrastructural (waste and water treatment) and embodied (kidneys; macroinvertebrates) filtering relations in Danish and Mexican water ecologies. By studying their histories, diagnostic capacities, governance and embodiments, this project will produce groundbreaking theoretical, methodological and empirical knowledge. It will connect the distinct subfields of medical and environmental anthropology and offer valuable insights for policy makers, practitioners and citizens. It will do this by reconceptualizing planetary health as a filtering assemblage, excavating the role it must play in shaping liveable landscapes. FILTERSCAPE provides a pluralistic, legible and collaborative platform. Anchored in an anthropology sensitive to space and time, it will ally with ecoscience, agroecology, engineering, environmental management and public health – fields where filtration is integral.

Keywords: anthropology,health,environment,contamination,filtration,
Using the In-Vivo Brillouin Microscope to assess the neuropathological features of Frontotemporal dementia models (ivBM-4FTD)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Italy,Portugal
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 28.0
Total project cost (EUR): 535425.0
EU funding (EUR): 535425.0
Participants: 2
Project status: SIGNED

The ivBM-4PAP project aims to develop a fast-scan Brillouin Microscope capable of sub-millisecond acquisition time to be suitable for In-Vivo measurements in cells and tissues, applicable to the field of biomedicine. This represents a major breakthrough in the field of microscopy since the long acquisition time of the today standard techniques has limited their use only to fixed samples. Thus, the ivBM will allow the measurement of the dynamic changes of mechanical properties of sub-cellular structures in living cells in real time. This will be extremely relevant to uncover the protein aggregates and the pathophysiological mechanism of different neurodegenerative diseases. Among them, within this proposal, we aim to shed light on the mechanism driving the onset and the progression of frontotemporal dementia (FTD), the most common cause of dementia in younger people with a devastating prognosis and no effective treatment. Indeed, the poor translation of findings obtained from animal models to humans has contributed for the yet poorly understood disease mechanism and thereby for the failure rate in drug development. Hence, in this proposal, the UC partner will provide the consortium with in-vitro models (iPSCs and patient-derived brain organoids), that better address the specific neuropathological features of FTD patients. Also, to detect early disease phases, we will model genetic (GRN and C9orf72) mediated forms of FTD, where at-risk individuals, still asymptomatic, can be assessed prior to clinical conversion. These models will be used to test ivBM, performance in terms of reliability, spatial resolution and acquisition time. Moreover, ivBM will be used to assess the mechanical properties of the existing structures, their nature, changes in their mechanical properties and their relationship with FTD. Indeed, applying ivBM to this protein aggregation-based pathology could increase our capability for an early detection, improving patient’s prognosis and management

Keywords: ipscs,brain organoids,frontotemporal dementia,ftd,protein aggregates,ivbm,lysosomal dysfunction