Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Understanding the individual host response against Hepatitis D Virus to develop a personalized approach for the management of hepatitis D (D-SOLVE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Germany,France,Sweden,Italy,Romania
Call: Personalised medicine and infectious diseases: understanding the individual host response to viruses (e.g. SARS-CoV-2) (HORIZON-HLTH-2021-DISEASE-04, 2021)
Start date: 2022-10-01
End date: 2026-09-30
Duration (months): 48.0
Total project cost (EUR): 6754010.0
EU funding (EUR): 6754010.0
Participants: 8
Project status: SIGNED

Hepatitis D is by far the most severe form of chronic viral hepatitis frequently leading to liver failure, hepatocellular carcinoma and death. Hepatitis D is caused by coinfection of hepatitis B patients with the hepatitis D virus (HDV). Up to 20 Million individuals are infected with HDV worldwide including about 250.000 patients in the European Union. There is very limited knowledge on disease pathophysiology and host-virus interactions explaining the large interindividual variability in the course of hepatitis D. It is in particular unknown why 20-50% are spontaneously able to control HDV replication, why the majority but not all patients progress to advanced stages of liver disease and why only some patients show off-treatment responses to antiviral treatment with either pegylated interferon alpha or the novel HBV/HDV entry inhibitor bulevirtide. As HDV is an orphan disease, no multicenter cohorts of HDV infected patients are available with appropriate biobanking. There is also no reliable animal model available allowing to study host responses. Thus, there is an urgent clinical, social and economic need to better understand individual factors determining the outcome of infection and to identify subjects benefitting from currently available treatments. Hepatitis D is a protype infection which could hugely benefit from a novel individualized infectious medicine approach. We here aim to perform an unbiased screening of a large multicenter cohort of well-defined HDV-infected patients followed by mechanistic studies to determine the functional role of distinct molecules. Identified specific parameters could have an immediate impact on the personalized surveillance strategies and antiviral treatment approaches. D-SOLVE aims to reduce disease burden, improve patient?s quality of life and safe direct and indirect costs caused by HDV infection by combining exceptional clinical, immunological, bioinformatical and virological expertise from leading centers in Europe.

Keywords: hepatitis d,virological response,liver cirrhosis,hepatic decompensation,antiviral therapy
Altermagnetic Robust Topological Quantum Materials (ART.QM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Czechia,Germany
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2025-07-01
End date: 2027-06-30
Duration (months): 24.0
Total project cost (EUR): 207758.16
EU funding (EUR): 207758.16
Participants: 2
Project status: SIGNED

Topological band theory has revolutionized the understanding of electronic band structure in condensed matter and led to the discovery of novel material classes, such as topological semimetals, topological and magnetic topological insulators. The emerging field of altermagnetism combines the merits of both ferromagnets and antiferromagnets, which were until recently regarded as incompatible. Consequently, they exhibit phenomena unmatched by either of the two traditional magnetic phases. Combining topological protection with altermagnetically lifted spin-degeneracy promises unprecedented robustness and potential mediation of altermagnetic spin-transport properties of bulk to the surface. Understanding the fundamental mechanism of their formation promises far-reaching implications in the fields of spintronics, quantum and neuromorphic computing and superconductivity.

Keywords: altermagnetism,topology,berry curvature,orbital angular momentum,photoemission
SCALING UP CAPACITY TO SUPPORT CONDUCT OF CLINICAL TRIALS IN THE EAST AFRICAN COMMUNITY (SCALE-IT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Public-private partnerships
Destination: Global Health EDCTP3
Action type: Coordination and support actions
Partnership: EDCTP3 (JU-JTI)
Countries involved: Kenya,France,Uganda
Call: Strengthening regulatory capacity for supporting conduct of clinical trials (HORIZON-JU-GH-EDCTP3-2022-01, 2022)
Start date: 2023-06-01
End date: 2026-05-31
Duration (months): 36.0
Total project cost (EUR): 600312.5
EU funding (EUR): 600000.0
Participants: 3
Project status: SIGNED

The East African Community (EAC) has experienced significant increase in volume and complexity of clinical research driven by epidemics of emerging and remerging infectious diseases such as HIV, Ebola and COVID-19, requiring expertise in scientific and ethical review and conduct of research and a robust and pragmatic research regulatory framework. The overall goal is to strengthen scientific and ethics capacity in EAC for high quality research review, conduct and oversight, at international standards. The specific objectives are: 1. To train NRRA personnel, REC members, researchers and clinicians on scientific and ethics review and conduct of research with emerging and complex study designs including adaptive platform trials 2. To train NRRA personnel and REC members on oversight, monitoring and pharmacovigilance of clinical trials and 3. To train NRRA personnel, REC and research administrators on personal effectiveness and leadership skills (PELS) to manage the increasingly complex research processes. Methods: We will implement this project within a consortium of research scientists from the six partner states collaborating with the EU partner, with the East African Health Research Commission as the strong nucleus for coordination and dissemination of results. The project will be hosted at the Infectious Diseases Institute (IDI), where within a previous NIH funded program (5G11 TW011309-01) we built capacity for REC members, researchers and REC administrators for 7 RECs in Uganda, with significant improvement in knowledge, PELS, quality and turnaround time of research review and researcher satisfaction. This proposal fits within the scope of GH-EDCTP3-2022-01-05 call, whose aim is to strengthen clinical research capacity and improve efficiency of the regulatory environment for effective development, delivery and uptake of new and improved safe health technologies and rapid response to emerging epidemics guaranteeing international standards and attainment of SDG3.

Keywords: scale up
Frontiers Inside Roman Sicily: Culture, Economy and Society between Late Antiquity and the Early Byzantine Period (FIRS)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: France,Canada,Italy
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2026-09-30
Duration (months): 33.0
Total project cost (EUR): 275008.56
EU funding (EUR): 275008.56
Participants: 3
Project status: SIGNED

The Late Antique and Early Byzantine periods are crucial ones for the understanding of Sicily's socio-economic and cultural evolution from Antiquity to the Middle Ages. Recent research has shown that the island still played its centuries-old role then as a Mediterranean linchpin, and this realization has awakened scholars' interest for a period that has been dogged by an adverse historical bias (one of perceived ‘decline and decadence’) for a long time. A raft of new data from archaeological excavations and field surveys have sketched the outlines of the nuanced complexities of Sicilian society and its vibrant economy at this period, and its integration into multiple Mediterranean trade routes. Despite some progress overall, delay in the publication of old excavations, the paucity of syntheses available, and the difficulty in accessing existing datasets, are a hindrance to resolving some key problems about this important transitional phase in Sicilian history. For this reason, many scholars believe that a new multidisciplinary analysis of the period is essential. The FIRS project therefore focuses on four key sites in western Sicily, investigated during the second half of the 20th century but largely unpublished. These comprise the rural settlements of Campanaio and Castagna and the port cities of Palermo and Lilybaeum (Marsala). By analysing the quantity of material culture from the excavations and exploring the distribution of artefacts at a micro-regional scale, we aim to investigate the many and various causes that triggered changes in trading patterns, social behaviour, and cultural practices between the 5th and the 7th centuries AD. The expected results will undoubtedly affect the international scientific community dealing with similar issues in other Mediterranean regions. They will also positively impact Sicilian society and the local economy, promoting an awareness of important but often neglected aspects of the Sicilian Cultural Heritage.

Keywords: mediterranean,sicily,late antiquity,early medieval age,material culture,pottery,legacy data,gis
VAULT (VAULT)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Ireland
Call: EIC Accelerator Challenge: Technologies for Open Strategic Autonomy (HORIZON-EIC-2022-ACCELERATOR-01, 2022)
Start date: 2023-03-01
End date: 2025-02-28
Duration (months): 24.0
Total project cost (EUR): 3545125.0
EU funding (EUR): 2465750.0
Participants: 1
Project status: CLOSED

Techniques and methods of illegally gaining access to digital information have reached new heights and are not expected to slow down. So far, existing solutions showed they are not able to keep data secure. Companies and other organisations are struggling with this issue and fail to keep up with legal regulations and face potential backlash from the public. With our breakthrough solution we will tackle all existing issues concerning data protection. These include: encryption, performance, scalability and key storage issues. Our unique end-to-end encryption technology is based on proprietary code and encryption algorithm (patent pending). The technology has been successfully tested on over 500 million data sets in multi-user environments as well as against existing encryption techniques. For the first time, there will be a tailored end-to-end encryption solution for every type of organisation without any compromises in performance, scalability and data security.

Keywords: cloud security,network security,cryptography
DYNamic Management of Aircraft Configuration and Route Structures (DYN-MARS)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Single European Sky Air Traffic Management Research
Action type: Research and Innovation actions
Partnership: SESAR (JU-JTI)
Countries involved: Germany,Belgium,Netherlands,France,Switzerland,United Kingdom
Call: Industrial Research & Validation for Aviation Green Deal (HORIZON-SESAR-2022-DES-IR-01, 2022)
Start date: 2023-09-01
End date: 2026-08-31
Duration (months): 36.0
Total project cost (EUR): 6192794.0
EU funding (EUR): 3770315.68
Participants: 8
Project status: SIGNED

The DYN-MARS project aims to minimise the environmental footprint of flights during climb, descent and approach through novel avionic functions and improved arrival routes and procedures. It enables, for the first time, a complete holistic solution that combines airborne with Air Traffic Management (ATM) improvements connected by enhanced communication capabilities. DYN-MARS builds on previous SESAR work through the development of the permanent resume trajectory function, the concept of dynamic deployment of arrival route structures, the DYNCAT project’s Flight Management System (FMS) energy management function and new air–ground data exchanges in order to enable the visibility of the flight plan at both ends. The DYN-MARS solution will consist of both an enhanced FMS for aircraft and new airspace management techniques for Air Traffic Control (ATC). This solution opens the path for more environmentally friendly routing of aircraft in the terminal manoeuvring area whilst maintaining today’s safety level. Based on the uplink of dynamically assigned routes and other information, DYN-MARS aims to allow pilots to better plan their optimum vertical and speed profile in descent and approach while maintaining the required runway throughput. Downlink of the FMS computed trajectory allows for further improvement in the trajectory optimisation process between the aircraft and ATC. Increased flexibility in ATM will make it possible accommodate these optimised flight profiles. DYN-MARS will conduct 5 different exercises to validate its solution from both avionics and ATM points of view with related human performance aspects. DYN-MARS includes relevant aspects of air traffic management with new aircraft flight procedures to sustainably reduce the environmental impact of aviation (CO2, fuel burn and the noise exposure of communities) whilst supporting the demand for high airport capacity and without compromising safety standards.

Keywords: dyncat,aircraft energy management,dynamic routes,performance based navigation,flight management system,datalink,aircraft noise reduction,sustainable aviation,4d trajectory based operation
Oral antibiotic outpatient therapy vs. placebo in the treatment of uncomplicated acute appendicitis: a randomized double-blind placebo-controlled noninferiority trial (APPAC IV)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention,  Diagnosis and T reatment of Human Diseases
Panel description: Medical technologies  and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions , pharmacology, preventative  medicine, epidemiology and public health , digital medicine
Countries involved: Finland
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-03-01
End date: 2029-02-28
Duration (months): 60.0
Total project cost (EUR): 1994895.0
EU funding (EUR): 1994895.0
Participants: 2
Project status: SIGNED

Acute appendicitis is one of the most common surgical emergencies worldwide. For over a century, surgical removal of the appendix has been considered the only treatment option. Landmark trials by our experienced APPAC team have shown that imaging confirmed uncomplicated acute appendicitis is not a surgical emergency defining antibiotics to safe and effective also with only oral antibiotics avoiding unnecessary surgeries resulting in major cost and resource savings. However, the role of antibiotics remains a major knowledge gap. Our pilot APPAC III showed that even symptomatic treatment (placebo) may be sufficient warranting a larger noninferiority trial to assess whether antibiotics are needed in the treatment of uncomplicated acute appendicitis. APPAC IV is a randomized double-blind multicenter clinical trial comparing oral moxifloxacin with placebo in an outpatient setting. APPAC IV aims to evaluate whether antibiotics and hospitalization or both can be omitted in the treatment of uncomplicated appendicitis further significantly increasing cost savings and patient satisfaction; almost 2/3 of all appendectomies (approx. 550.000 operations in Europe), the associated hospital stays, and potentially also antibiotics could be avoided. The growing global health issue of antibiotic resistance threatens effective prevention and treatment of infections. Studies on rational use of antibiotics are warranted and especially in the changing treatment paradigm of such a common disease. The translational MAPPAC II (Microbiology APPAC) substudy includes serum, rectal and fecal samples of the APPAC IV trial patients pre- and post-therapy. The effects of antibiotics on gut microbiota, gut health and correlation to serum cytokines are evaluated in this unique real-life randomized patient cohort. The development of antibiotic resistance and the underlying bacterial defence mechanisms will be evaluated in E. coli and microbiome using microbial single-cell technologies and metagenomics.

Keywords: appendicitis uncomplicated acute appendicitis antibiotic therapy symptomatic therapy placebo appendiceal microbiota antibiotic resistance gut microbiota dysbiosis
Second implementation project for the ERIC Forum (ERIC Forum 2)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Other destinations
Action type: Coordination and support actions
Countries involved: Austria,France,Italy,Norway,Netherlands,Czechia,United Kingdom,Germany,Finland,Sweden,Spain,Poland
Call: Coordination and Monitoring of the European Research Infrastructure Consortia (ERICs) (HORIZON-INFRA-2023-ERIC-ART195-IBA, 2023)
Start date: 2023-09-01
End date: 2027-08-31
Duration (months): 48.0
Total project cost (EUR): 2999463.88
EU funding (EUR): 2999463.88
Participants: 26
Project status: SIGNED

The ERICs (European Research Infrastructure Consortia), under the umbrella of the ERIC Forum, represent one of the leading science policy voices in Europe and play a key role in structuring the research infrastructure landscape. Following the successful set-up and implementation of the ERIC Forum (2019-2022), further efforts are needed to consolidate its achievements and expand the coordination and monitoring of the ERICs. This project aims to structure the cooperation between ERICs, support the implementation of the ERIC Regulation and ERICs services, and consolidate the integration of the ERICs in the European Research Area by deepening the ERIC Forum’s contribution to research policies. To reach its objectives, the project relies on a multi-disciplinary consortium involving all identified ERICs, both multi- and single-sited, and representing the five science clusters of the ERICs. The project is structured in four thematic pillars: 1) Monitoring and Reporting, 2) Reinforcing European research infrastructure policy and international cooperation; 3) Implementing the ERIC Regulation, strengthening capacities and identifying possible shared resources; 4) Coordinating the project, ERIC Forum Executive Board secretariat and communication. The activities carried out within the project will ensure the implementation of specific results on three key target groups: the ERICs and ERICs-to-be, in order to increase their knowledge and propose solutions for key aspects of the ERIC Regulation implementation; the policy-makers and stakeholders by setting-up and managing the new ERIC Forum monitoring and reporting platform, thus ensuring an easy access to updated and consolidated data and information about the ERICs, as well a further strengthened role in the European science policy; and finally the users, as the project will investigate the sustainability and open access of its services, as well as address the challenges related to the commercial aspects of service provision.
Model Transfer and its Challenges in Science: The Case of Economics (MODEL TRANSFER)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: The Human Mind and Its Compl exity
Panel description: Cognitive science, psychology, linguistics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2021-STG, 2021)
Start date: 2023-04-01
End date: 2029-03-31
Duration (months): 72.0
Total project cost (EUR): 1499476.25
EU funding (EUR): 1499476.0
Participants: 1
Project status: SIGNED

How can a single model be used to study predator-prey interactions in biology, the growth of cancer in medicine, and the business cycle in economics? And how is this practice supposed to contribute to progress in science? To answer those questions, we need to understand how models are transferred across domains. While model transfer is one of the most pertinent phenomena in modern science, philosophers have not yet given it due attention. Our project will fill this lacuna in a ground-breaking way: we will provide a comprehensive philosophical investigation of model transfer, its challenges, and its implications for scientific progress by innovatively combining approaches from philosophy and history of science with computational methods that are themselves new to philosophy. Because the literature so far neglects model transfer in the social sciences, we will focus on economics as an exemplary case that provides insights for the social and natural sciences alike. The main objectives of this project are to: (1) develop methodological and conceptual tools to study model transfer across scientific domains; (2) apply those tools to philosophically investigate model transfer and its challenges in science; (3) explore the implications of our results for the relationship between model transfer and scientific progress. This project will place model transfer upfront on the philosophical agenda. Thereby, our research will impact an extensive literature on scientific models and modelling in philosophy of science and the social sciences. By applying computational methods to study model transfer, it will push their use in empirical philosophy of science and Integrated History and Philosophy of Science. It will challenge established philosophical concepts of progress in light of such model transfers. Finally, it will inform scientific and science policy debates about how to overcome challenges to model transfer so that progress in model-based science can be ensured.

Keywords: model transfer in science,integrated history and philosophy of science,philosophy of the social sciences,philosophy of economics,empirical philosophy of science in practice,economics,scientific progress