Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
ROAD trailer design - use of Type V theRmoplastic tube with light composite structure for HYdrogen transPort (ROAD TRHYP)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: France,Belgium,Poland,Slovakia
Call: Increased hydrogen capacity of GH 2 road trailers (HORIZON-JTI-CLEANH2-2022-1, 2022)
Start date: 2023-01-01
End date: 2026-06-30
Duration (months): 42.0
Total project cost (EUR): 2642912.59
EU funding (EUR): 2499999.5
Participants: 11
Project status: SIGNED

Nowadays, existing trailer transportation solutions use tubes with a working pressure between 200 and 300 bar. This is not efficient in terms of quantities or cost to address large refuelling stations knowing the upcoming ramp-up of fuel cell-based vehicles. The overall objective of the ROAD TRHYP project is to develop and validate a trailer integrating new thermoplastic composite tubes (Type V) to reach Clean Hydrogen Partnership objectives by maximising the quantity of H2 transported while satisfying end-user requirements (safety, ability to be decontaminated) and enforced regulations with a low TCO. By the end of the project, the consortium will design a trailer capable of handling a payload of 1.5 tonne of H2 with 700 bar tubes and a capex lower than 400 €/kg. This enables the decrease of the number of transport rotations between the site of production and the delivery site, consequently the reduction of the environmental footprint of transporting compressed hydrogen, but also a downsizing of the compressor at the HRS. In the meantime, the project will heavily investigate new fire testing methodologies and safety barriers for type V adoption, results which will be disseminated to key policy makers and regulatory committees. ROAD TRHYP’s overall ambition is to develop Europe’s value chain of type V technologies. More specifically, the project intends to address all manufacturers across Europe who could benefit from the project’s innovative process and materials. Beyond the targeted commercial type V trailers applications, the knowledge developed on composite materials could benefit main actors in the mobility sectors or the hydrogen storage for inter-seasonal energy storage. As a consequence, the project would help achieve the European Green Deal making hydrogen a widespread energy carrier, by 2030.

Keywords: hydrogen transportation,trailer,hydrogen tank,thermoplastic composite,safety,hydrogen refuelling station
Investigation of affective input during object encoding in the perirhinal cortex (EmotionObjectCoding)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Norway
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2023-05-01
End date: 2025-04-30
Duration (months): 24.0
Total project cost (EUR): 226751.04
EU funding (EUR): 226751.04
Participants: 1
Project status: CLOSED

In our everyday life, we ascribe certain emotional value to some objects. More specifically, we ascribe a valence to some objects, which is the degree to which something can be pleasurable or averse, leading to an emotional response when we interact or remember them. In the act of learning and remembering an object, the brain executes a complex set of operations, integrating multiple sensory inputs (vision, smell, touch, sound, etc.) and the corresponding valence of the object to generate a unique mental representation, used to recognize and distinguish one object from another. This is known as object encoding. There is plenty of evidence linking the activity of the main hubs of emotional information processing (Amygdalar nuclei) and object encoding in the brain (perirhinal cortex), but a precise description of how notions of valence are incorporated during object encoding, have not been investigated, in part due to the technical challenges involved. EmotionObjectCoding will make use of Neuropixel, a powerful and new technology, enabling for the first time, the recording of population-level activity with high temporal resolution. This approach will be complemented with in vitro electrophysiological and optogenetic tools, providing a precise description of the neural circuits involved in the incorporation of valence during object encoding. Taken together, these innovative methods, will provide the groundwork for developing new hypothesis for the role of affective input during object encoding. Furthermore, this project will contribute to create a clearer picture about how our emotional well-being affects other important cognitive processes such as learning and potentially, disorders such as PTSD and Alzheimer’s disease.

Keywords: perirhinal cortex,basolateral amygdala,neuropixel,object encoding
Harnessing the Sun: Structural elucidation of the photoprotective Photosystem II interactome (PHOTO-LINK)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-11-15
End date: 2024-11-14
Duration (months): 24.0
Total project cost (EUR): 211754.88
EU funding (EUR): 211754.88
Participants: 2
Project status: CLOSED

Splitting of water molecules by Photosystem II (PSII) in oxygenic photosynthetic organisms sustains oxygen evolution on Earth, making this complex central for life on this planet. Sunlight is arguably the most variable source of energy in natural environments, with variations in quantity and quality occurring in the range of seconds to hours, and photosynthetic organisms evolved an ensemble of photosynthetic mechanisms to thrive in every ecosystem. Consequently, the ecological success of photosynthesis relies on the interaction of a conserved PSII catalytic core with a plethora of interacting proteins - its interactome - to optimize light harvesting and drive the disassemble/repair cycle of excess light-damaged PSII. The structural association of PSII with its interactome is inevitably transient and therefore recalcitrant to classic approaches for structural determination. PHOTO-LINK will employ a novel multidisciplinary approach that combines structural proteomics, spectroscopy and cryo-electron microscopy (EM) to provide a complete picture of how photosynthetic organisms adapt their PSII interactome to ever-changing environmental conditions. The methodological approach will be developed initially using two ecologically divergent model organisms, the vascular plant Arabidopsis thaliana (At) and marine phytoplanktonic diatom Phaeodactylum tricornutum (Pt). The subsequent structural elucidation of the photoprotective mechanisms in the organism of choice will provide cutting-edge scientific knowledge, along with valuable directions for biotechnological improvement of light-use-efficiency in globally relevant crops to increase their productivity (thanks to data acquired in At) and/or to optimise CO2 sequestration and transformation in marine phytoplankton (thanks to data acquired in Pt).

Keywords: photosynthesis,photosystem ii,cross linking mass spectrometry,top down mass spectrometry,photoprotection,spectroscopy,interactome,protein protein interactions
Widening INNovations for ORGANIC food (WINN-ORGANIC)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Innovation actions
Countries involved: Italy,Sweden,Belgium,Spain,France,United Kingdom,Germany,Portugal,Netherlands,Hungary,Switzerland
Call: Sustainable organic food innovation labs: reinforcing the entire value chain (HORIZON-CL6-2024-FARM2FORK-02, 2024)
Start date: 2025-09-01
End date: 2029-08-31
Duration (months): 48.0
Total project cost (EUR): 6003750.0
EU funding (EUR): 5434499.5
Participants: 19
Project status: SIGNED

WINN-Organic will establish Organic Food Innovation Hubs (OFIHs) across 7 European countries (5 Member States:taly, Spain, Portugal, The Netherlands, Hungary;1 Associated Country: UK and 1 Third Country: Switzerland) that will address systemic imbalances in the organic food value chain and contribute to stimulating demand for organic food. Based on an Open and Systemic innovation ecosystem model, OFIHs will be the place for co-creating, testing, implementing and upscaling innovative solutions focusing on processing (small scale-controlled fermentation, low heat pasteurization and low pressure drying); sustainable packaging (new biodegradable/compostable bioplastics); and open-source digital infrastructure (short-supply chains, food procurement and an open food supply network) applicable in the organic fruit, vegetable and dairy sectors in Europe and adaptable to the needs of organic operators. Co-learning and knowledge exchange (Community of Practice, training, capacity building, cross-fertilisation) will drive replication that will trigger innovation up-scaling and out-scaling and connect multiple actors within local organic food systems. The MAA will be based on the adoption of the Living Lab and quintuple helix approaches for setting up OFIHs and steer their rolling out. New business and financial models will be identified and adapted, and strategies will be designed to maximize impact. The sustainability impacts of the WINN-Organic innovative solutions and approaches will be assessed by a holistic framework and serve as input for further developments. WINN-Organic will provide policy recommendations for post-2030.

Keywords: organic food,organic food innovation hub,open innovation
Molecular mechanisms, functions and applications of RNA-guided DNA transposons (BROADCAST)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Molecules of Life: B iological  Mechanisms , Structures  and Functions
Panel description: For all organisms : Molecular biology , biochemistry, structural biology, molecular biophysics , synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Austria
Call: ERC STARTING GRANTS (ERC-2023-STG, 2023)
Start date: 2024-01-01
End date: 2028-12-31
Duration (months): 60.0
Total project cost (EUR): 1499403.29
EU funding (EUR): 1499403.29
Participants: 1
Project status: SIGNED

Genome engineering has transformed life science research and enabled revolutionary applications in biotechnology and medicine. Despite recent advances brought by the development of CRISPR-associated genome editing nucleases, a universal strategy for efficient site-specific gene editing and insertion in a range of organisms or cell types is currently unavailable. Transposons are natural genome remodelers and gene delivery vectors that modify and transfer genetic information across the tree of life by moving within and between their host genomes. To this end, they encode a vast and diverse reservoir of nucleic acid-targeting and -processing enzymes, whose molecular mechanisms are yet mostly unexplored. Building on our recent structural and biochemical studies, the goal of this project is to advance our mechanistic knowledge of RNA-guided DNA transposons in order to understand their biology and guide their repurposing as next-generation genetic tools. Specifically, the proposed studies will investigate (i) the mechanisms of RNA-directed DNA mobilization of CRISPR-associated transposons (CASTs), aiming not only to provide insights into their molecular function but also to inform their technological development, (ii) the molecular activities and architectures of TnpB-like transposon proteins, recently identified putative RNA-guided endonucleases of prokaryotic and eukaryotic origin, with the ultimate goal of supporting their application as ultra-compact, broadly applicable genome editors, and (iii) the translation of designer CASTs into a novel programmable DNA insertion technology for precision genomic profiling and engineering. Altogether, the proposed studies will not only make key contributions to the molecular understanding and harnessing of RNA-guided transposons in nature and technologies, but hold the long-term potential to address current challenges in genome editing, biotechnologies and precision medicine.

Keywords: mobile genetic elements,crispr cas systems,genome editing,cryo electron microscopy,x ray crystallography
New Digital Twins for Biological Innovation (NEWTON)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Spain
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2025-POC, 2025)
Start date: 2025-10-01
End date: 2027-03-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: SIGNED

Computational analysis of experimental measurements is crucial for advancing fields ranging from basic biotechnology to applied biomedicine. However, the rapid generation of increasingly complex data by laboratory equipment has outpaced the development of computational tools, leading to significant loss of valuable information. NEWTON addresses this challenge by developing Digital Twins (DTs) for (i) laboratory equipment and (ii) experimental procedures. These DTs will serve as computational mirrors, replicating the equipment used for sample characterization and the protocols employed in experiments. By capturing the intrinsic features of the equipment, how it derives experimental values from living cells, and the impact of protocols on samples, DTs will unlock unprecedented insights from experimental data. Existing computational tools could be integrated with DTs to enhance their analytical capabilities. Importantly, DTs are not intended to replace existing tools but to augment them, enabling comparisons and predictions that are currently unattainable, thus overcoming current bottlenecks. A preliminary test using a DT of a flow cytometer has already demonstrated its potential within our laboratory, allowing us to investigate bacterial phenotypes in novel ways and revolutionizing our approach to cytometry data analysis. Building on this success, NEWTON will advance initial conceptual studies to practical validation in small- and large-scale setups. Use cases during this validation phase will span biomedical applications, industrial cytometry fabrication, and bioengineering research. Looking ahead, NEWTON will assess the scalability of this technology, with a long-term vision of creating a modular DT of an entire molecular biology laboratory—where NEWTON DTs serve as foundational components. A comprehensive exploitation plan will ensure the project’s impact extends well beyond its lifespan, driving innovation across multiple domains.
Mechanisms of human mRNA packaging and export (mRNApackex)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Austria
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-05-01
End date: 2026-04-30
Duration (months): 24.0
Total project cost (EUR): 284915.66
EU funding (EUR): 199440.96
Participants: 1
Project status: SIGNED

The export of mRNA from the nucleus to the cytoplasm is an essential step in eukaryotic gene expression. This process requires that only fully processed mRNAs are exported, while undesirable RNAs are degraded in the nucleus. This selectivity is proposed to be mediated by the packaging of mature mRNA by export factors, protecting mRNA from nuclear degradation and licensing it for export to the cytoplasm. However, this model has not been directly and thoroughly tested. Furthermore, the full range of factors that promote the selective packaging and export of mRNA is not yet known. In this proposal, I propose an interdisciplinary and collaborative project that addresses these two major outstanding topics in gene expression. To address the role of mRNA packaging as a key driver of nuclear export versus degradation, I propose to employ a time-resolved transcriptomics and modeling approach to simultaneously measure nuclear mRNA export and degradation rates, modulating mRNA compaction state with rapid protein degradation. Next, I will employ ORF-tag, a novel genome-wide gain-of-function screening method that will determine the full list of proteins sufficient to drive nuclear mRNA export. I will then characterize promising novel export factors using transcriptomic and biochemical approaches to integrate these proteins into our structural understanding of nuclear mRNA packaging. The diverse methodology of this project, the technical support both within the host labs and the facilities on campus, and the high quality of training resources and supervision available will facilitate my own development as a scientist and prepare me perfectly to establish my own independent research group. Through my relocation from the UK to Austria, I will expand the European RNA biology network, forging future international collaborations. My background in molecular and computational biology will allow me to execute this impactful project and answer fundamental questions in gene expression.

Keywords: mrna packaging,mrna export,mrna degradation,high throughput screening
Meta-complexity: A Unified Approach to the Complexity of Proofs and Computation (METACOMP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer Science and Informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: United Kingdom
Call: ERC ADVANCED GRANTS (ERC-2024-ADG, 2024)
Start date: 2026-01-01
End date: 2030-12-31
Duration (months): 60.0
Total project cost (EUR): 2454938.0
EU funding (EUR): 2454938.0
Participants: 1
Project status: SIGNED

One of the most fundamental questions in computer science is the P vs NP question, which asks if every computational problem with efficiently verifiable solutions is efficiently solvable. Equivalently, it asks if all propositional tautologies have proofs that can be found efficiently. The answer is widely believed to be negative, but we lack a rigorous justification for this belief. The field of computational complexity approaches P vs NP and related questions by showing lower bounds (i.e., impossibility results) on efficient computations, while the field of proof complexity approaches these questions by showing lower bounds on efficient proofs for propositional tautologies. Despite much effort, the best known lower bounds in both computational complexity and proof complexity are quite far from resolving the P vs NP question, and there are significant barriers to the success of known techniques. In this project, we will approach fundamental lower bound questions in computational complexity and proof complexity using the recently developed conceptual framework of "meta-complexity". Meta-complexity studies the complexity of computational problems and propositional statements that are themselves about complexity, eg., the Minimum Circuit Size Problem, which asks if a given Boolean function has small Boolean circuits. Concepts and techniques from meta-complexity have been instrumental in major recent advances in theoretical cryptography and average-case complexity, overcoming known barriers. We will extend this methodology to attack some of the deepest questions in theoretical computer science, by showing new lower bounds on both proofs and computation, establishing strong connections between computational complexity and proof complexity, and giving applications to explicit constructions, learning and hardness of approximation. A key aspect of our approach is that meta-complexity is a unifying framework, which applies equally well to proofs and computation.

Keywords: computational complexity,proof complexity,pseudorandomness,lower bounds
European Research Infrastructure for Marine Bioprospecting (EUREMAP)

Framework: Horizon Europe — Excellent Science
Programme: Research infrastructures
Theme: Research infrastructures
Destination: Development and infrastructures
Action type: Research and Innovation actions
Countries involved: Norway,Germany,Spain,Belgium,Israel,Italy,Portugal,France
Call: Consolidation of the RI landscape – development of complementarities, synergies and/or integration between a set of pan- European research infrastructures (HORIZON-INFRA-2023-DEV-01, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 4997568.13
EU funding (EUR): 4997568.13
Participants: 13
Project status: SIGNED

The main objective of the EUREMAP consortium is to optimise the marine bioprospecting pipeline in Europe to enable state-of-the-art research and capacity for both academia and industry. The ambition is to leverage strengths available within European Research Infrastructures (RIs) and to align capacities and resources of the multidisciplinary field of marine bioprospecting. Hence, to increase the competitiveness of marine natural products in the field of drug discovery and to strengthen the blue bioeconomy in Europe, we will assemble a new pipeline that aligns and integrates the existing technical capacities and multidisciplinary expertise of the three European RIs - EU-OPENSCREEN (EU-OS), EMBRC and ELIXIR - in the field of marine natural products discovery. EUREMAP will develop a unique trans-RI integrated service in an European priority area, the blue economy. The pipeline will be an important part of the European blue growth strategy to stimulate economic growth through innovations in marine biotechnology. The potential for innovations and value creation in the blue biotechnology sector is high, and the sector is characterised by being multidisciplinary, knowledge-intensive and built on technology. Building a new European transnational RI service platform to support the competitiveness of an academic and industrial community in all aspects of this multidisciplinary field. EUREMAP will bring together an experienced, multidisciplinary consortium across three RIs to support and enable the discovery of novel bioactive natural products from marine organisms by utilizing novel technology to improve the capacity of European RIs.

Keywords: marine bioprospecting,blue bioeconomy,drug discovery,bioinformatics,marine organisms,bioactivity screening,biotechnology,ri,sustainability,user platform,service integration