Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Translational specialization of cellular identity in embryonic development and disease (TRANSCEND)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Cell Biology, Development, Stem Cells and R egeneration
Panel description: For all organisms : Structure and function of the cell, cell -cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approaches
Countries involved: Germany
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2023-03-01
End date: 2028-02-29
Duration (months): 60.0
Total project cost (EUR): 1981555.0
EU funding (EUR): 1981555.0
Participants: 2
Project status: SIGNED

A central question in developmental biology is how the genetic information is differentially interpreted to program cell-fate decisions essential for embryogenesis. The success of developmental cell-fate decisions relies on the accurate rewiring of the proteome to support rapid cellular identity changes. Here, we will address the fundamental question: How is the developmental transcriptome differentially translated in time and space to program cell-fate decisions? I hypothesize that the developmental competence for cell-fate decisions is controlled by fate-specific translational specialization factors (TSFs). TSFs program the selective and privileged translation of developmental genes in defined time windows to enable the acquisition of cell fate and maintenance of cellular identity. Notably, in a proof-of-principle study, we discovered that translational specialization in pluripotency poises future lineage choices in humans. The research program TRANSCEND has four work packages: (1) identifying candidate TSFs engineering cardiac fate at critical cell-fate transitions by cell-fate specific, systematic cataloging TSFs on ribosomal complexes; (2) dissecting the molecular and functional role of TSFs in cardiac cell-fate specification by combining targeted CRISPR screens and tethered functional approaches; (3) decoding the mechanisms, modalities, and design principles by which TSFs program cardiac identity by using a holistic approach, including loss-of-function studies in cardiac 2D, organoid, and mouse models along with systems-wide methods such as eCLIP-seq and TCP-seq; and (4) engineering translation specialization modules to ameliorate pathological cardiac hypertrophy using patient-derived in vitro and murine in vivo models. Ultimately, the proposed research program TRANSCEND aims at transforming our current understanding of translational control over cell-fate decisions and opening up innovative avenues for controlled therapeutic restoration of cardiac function.

Keywords: cell fate specification,regulation of translation,rna binding protein,cardiac development,gene regulation,cardiac hypertrophy,cell fate decisions,regulation of cellular identity
Ethical design of holography with dense wireless networks for palliative care (HOLDEN-CARE)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Research and Innovation actions
Countries involved: Finland,Czechia
Call: Hop on Facility (HORIZON-WIDERA-2023-ACCESS-06, 2023)
Duration (months): 17.0
Total project cost (EUR): 570113.75
EU funding (EUR): 570113.75
Participants: 2
Project status: CLOSED

Ubiquitous perception, by sensing objects, subjects and gestures, is a pivotal challenge for future technology: it enables personalized services such as smart living, automated logistics or interaction through free-space gestures. However, it also challenges ethical and moral boundaries and threatens privacy. HOLDEN proposes a radically new approach to perception by concisely analysing ethical constraints and privacy risks while re-thinking RF-based sensing. We establish necessary conditions for privacy-preserving and ethically compliant sensing and develop new paradigms respecting these constraints. We will utilise technology developed in the HOLDEN project in the frame of a specific case study with people in palliative care. Particularly, in collaboration with medical experts and bioethicists based in the Czech Republic, we will install the technology in in-home care environments to measure patient movement and autonomy. The purpose of the study is to understand the transparency and information needs expected and required by individuals towards the technology. The study aims to understand how to design the technology in an ethically acceptable way, in which it also benefits the individual and so that it can be used in health care.

Keywords: value based design,bioethics,healthcare,palliative care
Reducing nutrition-related noncommunicable diseases in adolescence and youth: interventions and policies to boost nutrition fluency and diet quality in Africa (ARISE-NUTRINT)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Health
Theme: Health
Destination: Tackling diseases and reducing disease burden
Action type: Research and Innovation actions
Countries involved: Germany,Netherlands,Spain,Serbia,Burkina Faso,Ethiopia,Tanzania, United Republic of,Nigeria,Uganda,South Africa,United States,Ghana
Call: Non-communicable diseases risk reduction in adolescence and youth (Global Alliance for Chronic Diseases - GACD) (HORIZON-HLTH-2022-DISEASE-07, 2022)
Start date: 2023-01-01
End date: 2026-12-31
Duration (months): 48.0
Total project cost (EUR): 4291236.25
EU funding (EUR): 4291236.0
Participants: 14
Project status: SIGNED

Noncommunicable diseases (NCDs) are a major public health problem, resulting in over 70% of global deaths each year; the majority (85%) of deaths occur in low-and middle-income countries. While cost-effective, evidence-based best practices are available, implementation of these interventions has remained a critical challenge, particularly ones targeted at promoting health behaviors among adolescents and youth. Despite the importance, few studies have been undertaken to identify the facilitators and barriers to the implementation of evidence-based interventions that promote healthy behaviors among adolescents and youth in sub-Saharan Africa (SSA). "Reducing nutrition-related noncommunicable diseases in adolescence and youth: From nutrition literacy to fluency" will take a major step towards improving the implementation of evidence-based interventions – nutrition education and SSB policy - that promote healthy behaviors among adolescents and youth in SSA to reduce the impact of NCDs. With the use of a multi-disciplinary approach, innovative design, and cutting-edge tools, the proposed project aims to establish a global alliance to prevent and reduce nutrition-related NCDs among adolescence and youth in SSA region, by shaping individuals’ health behaviors through nutrition literacy and fluency, assessing the impact and performance of the nutrition-related policy and promotion programs, and providing flexible, cost-effective, scalable, reliable, secure and easy-to-use tools. The establishment of an Africa Think Tank for Adolescents and Youth Health, and annual forums will help facilitate continuous engagement with key stakeholders to enhance buy-in, acceptance and relevance of the project outputs. Ultimately, the expected wider effects of this project include improved NCD prevention policy adoption and implementation, improved policies and evidence-informed decision making amongst key stakeholders, and ultimately decreased avoidable mortality due to NCDs.

Keywords: adolescent and youth nutrition,nutrition related ncds,health literacy,nutrition fluency,diet quality,behavioral intervention,policy,healthy lifestyles,implementation science,sub saharan africa
Atomistic Modeling of Advanced Porous Materials for Energy, Environment, and Biomedical Applications (STARLET)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Products and Processes Engineering
Panel description: Product and process design, chemical, civil, environmental, mechanical, vehicle engineering, energy processes and relevant computational methods
Countries involved: Türkiye
Call: ERC CONSOLIDATOR GRANTS (ERC-2023-COG, 2023)
Start date: 2024-04-01
End date: 2029-03-31
Duration (months): 60.0
Total project cost (EUR): 2000000.0
EU funding (EUR): 2000000.0
Participants: 1
Project status: SIGNED

Metal organic frameworks (MOFs) are advanced porous materials with multifunctional tunable properties offering great potential for energy, environment, and biomedical technologies. The number of MOFs is increasing at an exponential rate. Studying millions of MOFs for different applications by random material selection using iterative experimental testing or brute-force computational simulations is impossible. The full potential of MOFs for target applications can only be unlocked if the storage and transport properties for important chemical and biological guest molecules trapped in the pores of each MOF are known. In this project, I will create a materials intelligence ecosystem for precisely assessing guest storage and transport properties of all MOFs by combining state-of-the-art atomistic calculations, molecular simulations, machine learning, and data science, integrated with past and future experiments. I will focus on ten critical guest molecules to address the key societal challenges of our world: hydrogen and methane to use MOFs for clean energy storage; ammonia, carbon monoxide, carbon dioxide, nitrous oxide to use MOFs for capturing toxic gas and combatting global warming; fluorouracil, methotrexate, nitrogen, oxygen to use MOFs as nanocarriers for anti-cancer drug therapy and biomedicine. The ground-breaking gains of my project will include the creation of the world’s first database for guest storage and transport properties of millions of MOFs; accurate assessments of new technologies by precise MOF-application matching; and generating design guidelines for high-performing MOFs to accelerate discovery of new materials. My novel methodology synergizing theory and data-driven science will greatly extend the reach of current experimental and computational studies by discovering new thermodynamic theories that will be extendible to other material classes and providing atomic-level insights into MOF-guest interactions that determine materials’ performances.

Keywords: metal organic frameworks,computational modeling,porous materials
Elucidating the genomic architecture of genetic load (SV-Load)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France,Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-05-01
End date: 2027-04-30
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 2
Project status: SIGNED

How can we accurately measure and predict genetic load? In SV-load, I aim to understand how an often overlooked, but high impact class of genomic variation contributes to genetic load. Structural variants (SVs) have been shown to have significant implications for individual and population fitness and impact more genomic content overall than traditional whole-genomic markers (i.e., single nucleotide polymorphisms, SNPs). However, whole-genome SVs are underrepresented in population studies as they have historically been difficult to characterise and genotype at the population-scale. As a result, the dynamics of SV diversity in the face of fundamental evolutionary processes (e.g., selection, recombination, and population size) is relatively unresolved and hinders the study of genetic load across disciplines. To address this gap, I will implement in-silico approaches to forecast and experimentally test how SVs respond to different demographic parameters in a non-model species (Coelopa frigida). During my PhD and first postdoc I honed the sequencing and bioinformatic skills necessary to study genome-wide SVs at the population-scale. I will bring this expertise to the host lab of Dr. Mérot and Dr. Glémin at the Université de Rennes (UR, France), experts in the field of evolutionary biology and ecology. Training with the host lab, and a secondment with A/Prof Bataillon at Aarhus University (AU, Denmark) will broaden my modelling and experimental skills. Through these collaborations, I will learn new multidisciplinary approaches in modelling, statistical genomics and experimentation. This project will not only complement my existing skills but enable me to gain a competitive advantage in establishing my European career in the exciting and dynamic field of evolutionary biology. Finally, this project will aid in advancing our understanding of genetic load, which remains a fundamental challenge for biologists in the agriculture, conservation, and evolution research sectors.

Keywords: evolution functional genomics genome evolution population genomics modelling
Toward Perovskite-based Electrically Pumped Laser via Facile Facet Engineering (PELFE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

Beyound traditional III-V laser diodes, solution-processable solid-state lasing (SPSSL) has been in spotlight due to promising versatility and simplified fabrication for integration into various platforms. Among the classes of optical gain media, organic materials, colloidal quantum dots (CQDs), and perovskites have been extensively explored. While organic materials have shown promise, challenges remain in addressing triplet and polaron losses. CQDs, on the other hand, have demonstrated significant progress in suppressing undesirable loss mechanisms. Perovskites, a rising material, present distinct advantages including ease of formation through room-temperature processes and remarkable optical properties (low threshold of ASE and continuous wave lasing). However, two primary challenges face perovskite implementation. Firstly, there is a notable gap in fundamental studies, specifically in understanding the correlation between auger recombination and optical properties. Secondly, the soft-ionic nature of perovskites poses a challenge for surface shell modification, necessitating the development of suitable treatment methods. The research aims to achieve electrically pumped amplified spontaneous emission through a comprehensive study of perovskites and the introduction of a novel modification strategy. The project encompasses three objectives: understanding the correlation between compositions and ASE thresholds, maximizing the optical properties of perovskite nanocrystals (PNCs) through surface etching and facet reconstruction, and implementing PNCs into LEDs with a focus on modulating Joule heating and introducing distributed bragg reflectors. Overall, this research endeavors achieve world’s first electrically pumped ASE using perovskite, offering a promising avenue towards efficient, cost-effective, and widely applicable laser diode technology.

Keywords: perovskite,perovskite nanocrystals,facet reconstruction,perovskite leds,electrically pumped ase,laser
Tailored Bacterial Magnetic Nanoparticles For Biomedical Imaging (BacToMagicle)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Germany
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-11-01
End date: 2025-04-30
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

Of tremendous biomedical and clinical interest are magnetic iron oxide nanoparticles (MNP) that can be tailored to fulfil specific functions, for instance as actuated drug carriers, tracers for magnetic imaging modalities, or heat generators in magnetic hyperthermia for cancer therapy. However, their use in real-world applications has been hampered by lack of precise size control and magnetic tunability as well as by poor biocompatibility associated with their conventional synthesis. I propose a step-change approach for the light-powered bioproduction of high-quality magnetic nanoparticles by novel synthetic microbes generated in ERC-AdG Syntomagx, crafted precisely for their use in biomedical applications. Compared to commercial, chemically synthesized MNP, these novel bacterial MNP are expected to exhibit superior applicability and versatility, owing to their genetically tuned and uniform physicochemical and magnetic characteristics, available at high cost-efficiency and under sustainable manufacturing conditions. First, bacterial production and purification of the particles will be set up at large lab scale. In addition, their anticipated superior biocompatibility will be thoroughly assessed. Then, we will explore and demonstrate their performance in collaboration with various biomedical end users. As proof-of-concept we will deliver a formulation of bacterial MNP tailored as potent tracers in high-resolution magnetic particle imaging (MPI). With respect to the long-term goal of future commercial exploitation, we will explore patenting options and thoroughly assess the demand for such high quality biogenic MNP. I envision that our idea will revolutionize the biomedical MNP-market by opening it for the wealth of genetically tailored and highly functionalized bacterial MNP, suitable for a wide range of applications.
The Role of Military Equipment in Peacekeeping Operations: Advancing Knowledge on Mission Performance (ROMEO)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2025-04-01
End date: 2027-03-31
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

When are peacekeeping operations (POs) successful? A leading answer from quantitative peacekeeping research is that mission size and personnel composition matter. The larger the deployment, the higher the number of uniformed troops, and the more culturally different the peacekeepers, the better peacekeeping performance. Practitioners, on the other hand, oftentimes highlight that adequate military equipment is crucial in this regard. Due to the lack of structured cross-sectional, time-varying data on how POs are equipped, peacekeeping scholars have, thus far, not been able to directly evaluate these appeals in a systematic manner. Consequently, it is unclear whether POs are indeed under-equipped, whether and to which extent this varies across cases and what role equipment deficiencies play for peacekeeping performance. ROMEO addresses this significant research gap in three ways. First, it systematically synthesizes and structures information on how POs are equipped (RO1), recording which country contributes material to which PO, supporting which operational function, with how many items of equipment, using which specific system for 87 UN and non-UN POs in Sub-Saharan Africa between 1991 and 2023 (WP1). Second, ROMEO establishes basic empirical knowledge on military peacekeeping equipment (RO2) by descriptively exploring the new equipment data from WP1 and other sources along four dimensions – availability, suitability, state-of-the-art, and technical interoperability – to compare equipment deficiency over time (a), across UN and non-UN POs (b), and within different actors over time (c). Third, it advances our understanding on the conditions under which peacekeeping works (RO3) as it uses the multidimensional information from WP2 to statistically model the relation between military equipment deficiencies and the ability of POs to limit conflict-related violence, especially against civilians (WP3).

Keywords: peacekeeping,military equipment,civil conflicts,effectiveness,protection of civilians
Gender and Social dominance In the Modern World (GENSDOM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Denmark
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-04-01
End date: 2026-03-31
Duration (months): 24.0
Total project cost (EUR): 230774.4
EU funding (EUR): 230774.4
Participants: 1
Project status: SIGNED

Prior research has focused on how organizations achieve gender equality in terms of numbers, and found mixed results regarding the benefits of gender diversity to performance. In this project, I delve deep into the dynamics of gender and social dominance to understand the drivers of women representation in top management teams and the strategic implications of gender difference in social dominance across countries. Attempting to shed light on this urging topic, I combine insights from the social psychology, behavioral strategy, and international business literatures in order to develop and test novel hypotheses about how social dominance affects gender equality in top management teams and organizations' strategic decision-making. I will focus on four related research questions: 1) Is there a gender difference in social dominance among TMT members? 2) How do gender differences in social dominance influence top managers' contribution to strategic decision-making? 3) Do social dominant CEOs invest less in diversity and inclusion (D&I) policies? 4) How do gender differences in social dominance affect strategic decision-making, and D&I policies across different countries? In order to test my predictions, I use different research methodologies across different countries, to collect a novel large-scale database from a variety of sources including supervised machine learning based indicators of social dominance, surveys, databases and Glassdoor.com. The ambitious goal of this interdisciplinary project is to open a research stream which explores how gender differences in social dominance influence top executives, top management teams and organizations. The results have both an ethical and a business impact as they may help organizations to create more diverse top management teams, enrich managerial behaviors throughout the firm, motivate women in middle management, and improve firm performance.

Keywords: gender,diversity,inclusion,social dominance,top management teams