Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
TWINNING FOR EXCELLENCE TO ADVANCE RESEARCH IN THE ACTIVATION OF ANTI-TUMOR IMMUNE RESPONSE AFTER ELECTROCHEMOTHERAPY COMBINED WITH GENE ELETROTRANSFER OF pDNA ENCODING ICIs (ZAP Cancer)

Framework: Horizon Europe — Widening Participation and Strengthening the European Research Area
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Destination: Improved access to Excellence
Action type: Coordination and support actions
Panel: Life Sciences
Countries involved: Slovenia,France,Austria,Belgium,Italy
Call: Twinning Bottom-Up (HORIZON-WIDERA-2023-ACCESS-02, 2023)
Start date: 2024-10-01
End date: 2027-09-30
Duration (months): 36.0
Total project cost (EUR): 1499101.38
EU funding (EUR): 1499101.38
Participants: 6
Project status: SIGNED

More than a decade has passed since the first immune checkpoint inhibitor (ICI) was approved for the treatment of advanced melanoma, marking the beginning of immunotherapies in cancer treatment. However, even in the best scenarios with a combination of ICIs and standard therapies, durable benefit is not achieved in about half of patients. Therefore, new approaches are needed on how best to exploit the potential of ICIs. The scientific aim of the ZAP cancer project is to determine how a local ablative technique, electrochemotherapy with BLM, CDDP or OXA induced immunogenic cell death (ICD), can be combined with gene electrotransfer of pDNA encoding ICIs to elicit a systemic anti-tumor immune response. The ZAP cancer project plans to improve access to scientific excellence, optimize research management and accelerate the exchange of personnel, knowledge and ideas in the European Research Area (ERA) and the two participating institutions from the widening countries; the Institute of Oncology Ljubljana (IOLJ) and the Faculty of Health Sciences (FHS) of University of Ljubljana. ZAP cancer will expand the existing collaborative network with three leading European institutions: Institute of Pharmacology and Structural Biology, a department of the CNRS (IPBS-CNRS), Toulouse, France, Katholieke Universiteit Leuven (KUL), Leuven, Belgium, The Institute of Translational Pharmacology, Institute of the Italian National Research Council (CNR) and a new partner: The Medical University of Graz (MUG), Graz, Austria. Through the proposed project, a multidisciplinary network of cancer research centers will collaborate to establish a state-of-the-art, high-throughput multi-omics in vitro and in vivo research platform at IOLJ and FHS that will provide them with valuable new expertise and knowledge that will enhance their potential for future successful applications at the European and international levels.

Keywords: immune checkpoint inhibitors,electrochemotherapy,gene therapy,anti tumor immune response,increase of increase of scientific excellence,strengthening of administrative capacity
Young International Academics Postdoctoral Programme (YIA)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Luxembourg
Call: MSCA COFUND 2021 (HORIZON-MSCA-2021-COFUND-01, 2021)
Start date: 2023-05-01
End date: 2028-04-30
Duration (months): 60.0
Total project cost (EUR): 1432800.0
EU funding (EUR): 1432800.0
Participants: 1
Project status: SIGNED

The Young International Academics postdoctoral programme (YIA) is a career development program proposed by the University of Luxembourg (Uni.lu) to nurture early-career postdoctoral applicants to gain momentum in interdisciplinary/intersectoral research. YIA applicants are international talents willing to propose and realize their own interdisciplinary research projects through a bottoms-up approach. YIA will welcome, in two calls, a total of 10 postdoctoral fellows with 36-month contracts over 5 years. YIA is open to all disciplines and sectors, involving Uni.lu in the drive towards an increased interdisciplinarity and intersectorality, which are strategic for Uni.lu, for the country and for Europe. A unique aspect of YIA is its integration into Uni.lu’s Institute for Advanced Studies-Luxembourg (IAS) created in 2019 to promote interdisciplinarity and outreach towards the society. This integration provides the YIA fellows with (1) a supervision for interdisciplinary and intersectoral research with more than 350 potential (co)-supervisors, and with about 350 potential public-private partners, (2) peer and cross-generational interactions/mentoring through the IAS fellows, invited distinguished senior scientists, early career researchers, and a mandatory academic or industrial secondment, and (3) a truly international flavour in an environment that cherishes diversity and excellence. YIA fellows recruited at Uni.lu are offered competitive contracts with mobility fellowships and access to excellent research infrastructures. A professor of Uni.lu provides supervision for the primary discipline of the applicant’s project and a co-supervisor covers the complementary discipline/sector. The YIA fellows are offered an “à la carte” training including mandatory courses, to suits the fellow’s career aspirations, increase the fellow’s interdisciplinarity and employability. The YIA programme will support a rapid ramp into a long-term Uni.lu funding of postdoctoral IAS fellows.

Keywords: audacious and advanced studies,open science,citizen science,interdisciplinarity,intersectorality,international,outreach to society
From conformal symmetries and integrability to the Electron-Ion Collider (Conformal-EIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany,Hungary
Call: ERC ADVANCED GRANTS (ERC-2022-ADG, 2022)
Start date: 2023-10-01
End date: 2028-09-30
Duration (months): 60.0
Total project cost (EUR): 2264563.0
EU funding (EUR): 2264563.0
Participants: 2
Project status: SIGNED

The primary goal of this research proposal is to lay the foundations for precision predictions for the physics program in deep-inelastic scattering (DIS) at the Electron-Ion-Collider (EIC). The commissioning of the EIC will open a new era in the exploration of the strong interaction physics and the hadron structure at an unprecedented level of detail. This is expected to lead, among other results, to the clarification of the proton spin puzzle. The crucial ingredient for the success of this undertaking is the ability to confront experimental data to precise predictions for a those benchmark processes, which will form a core part of the EIC physics program: inclusive lepton-hadron DIS, including polarized beams; DIS charm- or bottom-quark production; deeply-virtual Compton scattering in off-forward kinematics. Capitalizing on recent theoretical advances, driven to a significant extent by the work of the PI, this proposal outlines a challenging and ambitious program to advance quantum chromodynamics (QCD) perturbation theory in order to achieve a theoretical description of the key observables at the EIC at percent level precision. The proposal puts forward a novel research methodology based on the systematic use of conformal symmetry and integrability, as realized in gauge theories with extended supersymmetry, such as the N=4 supersymmetric Yang-Mills (SYM) theory to reveal structural information on QCD results. Observables in lepton-hadron DIS are particularly well suited to turn the connections between N=4 SYM theory and QCD into a powerful computational tool, which leads to significant simplifications due to the hidden symmetries underlying integrable systems. Progress in this direction will open new avenues for research and will establish new bridges between the scientific communities in phenomenology and mathematical physics. The new QCD results will be used in the course of the project to explore precision phenomenology at the EIC.

Keywords: quantum chromodynamics,deep inelastic scattering,operator product expansion,perturbation theory
LiV is a platform that leverages the power of Blockchain to democratise access to inheritance management, reducing inefficiencies and ensuring compliance. (LIV)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Spain
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2024-06-30
Duration (months): 12.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

LiV is a platform that leverages the power of Blockchain to democratise access to inheritance processes, reducing complexity, inefficiencies and ensuring legal compliance. LiV allows any person to: -Make informed and simple decisions about their inheritance plan - Protect their assets and inheritance from getting lost - Prevent families’ fights and protect them from fraud - Complete simple inheritance processes after death - Manage, recover and regularise crypto inheritance LiV also allows 3rd parties, Financial Institutions and Governments to manage inheritance processes more effectively and to better support their customers’ during distressful times. LiV is creating a new seamless ecosystem which will completely reformulate the way these entities interact, work and engage. This will mean instant, transparent, cheaper and secure transactions for people and institutions. Our research has revealed that our blockchain approach is a game changing innovation that can potentially: - Increase inheritance planning adoption from a current 50% to a 75% (3/4 interviewees would use LiV) Part B - Page 2 of 10 - Reduce dormant assets (€50bn) and crypto (20%) to potentially “0” - Reduce time, costs and eliminate errors during inheritance processes by an average of 90% - Enable web3 compliance - Avoid sanctions to Financial Services and other entities With this, LiV will set the foundations for further legal-tech services that will put the EU at the vanguard of legal- tech innovation in a market valued at ~$500 Bn (2028). LiV provides access to legal services and contributes to build stronger institutions. With this LiV aims to contribute to the 16th United Nations Sustainable Development Goal and the European 2030 Digital Agenda. LiV also provides a sustainable non-paper-based process, which we estimate could reduce CO2 emissions by 5 million kg per year just in the EU. www.livcare.co

Keywords: legaltech
Energy-efficient hardware implementation of memristor-based in-memory computing (EEHIMIC)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Italy,Switzerland,Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 188590.08
EU funding (EUR): 188590.08
Participants: 3
Project status: SIGNED

Neuromorphic engineering is an emerging bio-inspired discipline that morphs the biological brain on custom silicon. Although memristors rose as a potential synapse to solve the density challenge in a memristive crossbar, the scalability of the crossbar is limited by its power dissipation and chip area. To contribute to low power dissipation, I focus on improving the energy efficiency of the synapses (non-filamentary category) and neurons, which are the fundamental constituents of the neural network-enabled IOTs. The energy efficiency of the synapses will be improved by applying fast switching pulses on the bulk-based synapses that result in low switching currents. The energy efficiency of the neurons will be improved by taking advantage of the FDSOI28nm technology node by which the neurons are designed. A dedicated PCB will be designed, assembled and mounted that house both the synapses, and the neurons, which will be energy-efficiently used to recognize digits or letters by unsupervised learning rule.

Keywords: neuromorphic engineering,neural network,unsupervised learning
Preservation and RecognItion of Spatial patterns using Machine learning (PRISM)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Germany
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-08-14
End date: 2026-08-13
Duration (months): 24.0
Total project cost (EUR): 189687.36
EU funding (EUR): 189687.36
Participants: 1
Project status: SIGNED

Ecological research necessitates the production of spatial maps representing an array of critical variables such as biodiversity, climate, land cover, and soil carbon storage. While current machine learning methods, such as the well-known random forest (RF), have been effective in generating maps for these variables, they often overlook the intricate spatial patterns inherent in ecological processes. The PRISM project seeks to introduce a novel approach that addresses this limitation by integrating and validating spatial patterns within machine learning models. The project will draw upon insights from various fields, including geography, landscape ecology, statistics, and computer science. To ensure the widespread dissemination and accessibility of its findings, PRISM will adopt a comprehensive open science approach, including manuscript publications, the development of open-source software, and the sharing of repositories containing data and code, enabling others to reproduce and build upon the project's results. Through this project, an exchange of knowledge is anticipated between the researcher and the host institution, fostering a collaborative partnership. Under the supervisor's mentorship, the researcher will acquire essential skills in group organization, grant preparation, and research leadership. The researcher will enrich the host institution by creating innovative methods for spatial data analysis, implementing impactful teaching methodologies, and sharing the principles of open science. Ultimately, the PRISM project is poised to fuel the researcher's interdisciplinary growth, positioning him as a valuable asset in both academia and industry. The project's outcomes have the potential to improve how ecological research is conducted, leading to more accurate predictions and a deeper understanding of complex spatial patterns in ecological systems.

Keywords: spatial ecology,landscape ecology,spatial machine learning,spatial autocorrelation
Rapidemic – A lysis buffer for a novel molecular point-of-care diagnostic device for sexually transmitted infections (Rapidemic)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Netherlands
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-06-01
End date: 2023-12-31
Duration (months): 7.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Sexually transmitted infections (STI) are some of the most prevalent endemic infections in Europe. Current diagnostic techniques for STI’s have important shortcomings, as they rely on central diagnostic laboratories with extensive high-throughput facilities with expensive equipment and trained personnel. Due to this, the turnover of patient samples can take up to a week. In the meantime, patients are experiencing shame and pain. This delay in diagnosis can also have more important consequences, such as continued spread of the infections, of the development of pelvic inflammatory disease, which can lead to infertility. This is why Rapidemic develops an innovative molecular point-of-care diagnostic device for fast and accurate diagnosis of chlamydia and gonorroea. With this test, patient samples no longer have to travel to a lab, but patients can immediately get tested at a sexual health clinic. This single-visit testing provides an opportunity for immediate treatment administration and to drastically reduce the patients discomfort, therby decreasing the barrier to test. To detect a pathogen’s DNA in the Rapidemic test, the bacteria first have to release the DNA. In this project, Rapidemic will be working on the research and development of a novel lysis buffer for gram negative bacteria, suitable for integration in a molecular point-of-care diagnostic device.

Keywords: health,medtech,healthtech,diagnostics,medical devices,momecular,point of care,std
Tackling the paradox of growth and sustainability - A SDG indicator framework for water, energy, land, and materials based on postgrowth and resource nexus thinking (PostReNex)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Spain
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-10-01
End date: 2025-09-30
Duration (months): 24.0
Total project cost (EUR): 165312.96
EU funding (EUR): 165312.96
Participants: 1
Project status: SIGNED

The United Nations' Sustainable Development Goals (SDGs) suggest a useful framework; however, they lack well-defined indicators, failing to account for resource interlinkages. Resource nexus thinking has gained traction recently since it targets synergies and helps avoid competition of resources. Additionally, decoupling economic growth from emissions and resource use has been sought after, and attempted through 'sustainable growth' and 'green growth' within the SDGs. This is a paradox since growth and climate mitigation are not compatible; growth has significant environmental and social costs. Consequently, critics of green growth (and subsequently the SDGs) are gravitating towards degrowth (which is not mentioned in the SDGs), whose goal is to reduce economic activity, reaching a level that is ecologically sustainable. Although degrowth has the virtue of recognising the concrete limits of global growth, it is still under development and has faced criticism, since it rarely presents implementable actions, with most research concentrating on conceptual essays. This project will integrate the postgrowth and resource nexus literatures to construct an analytical framework of indicators, to improve on existing SDG indicators (regarding water, energy, land, and materials), in a move away from green growth and decoupling principles, and towards principles of equity and sufficiency. The framework will consist of critical indicators accounting for embodied resource use to help towards an equitable downscaling of resource throughput. The extent of North and South’s “unequal exchange” will be quantified, critical resources and degrowth potential for different countries will be identified, while the limits to growth will be tested. Finally, this project will inform a meaningful discussion around green growth/postgrowth within the SDGs and elaborate specific and practical policy recommendations for the improvement of SDG indicators for both 2030 and beyond.

Keywords: resource nexus,water energy land materials nexus,postgrowth,degrowth,ecological economics,indicators,sdgs,global south,global north,unequal exchange
Tibetan Obsolete Mortuary practices and afterlife Beliefs. Language conservatism of religious writings in the service of Proto-Bodish reconstruction (TOMB)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Ireland
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-01
End date: 2026-08-31
Duration (months): 24.0
Total project cost (EUR): 199694.4
EU funding (EUR): 199694.4
Participants: 1
Project status: SIGNED

TOMB (Tibetan Obsolete Mortuary practices and afterlife Beliefs. Language conservatism of religious writings in the service of Proto-Bodish reconstruction) aims to yield a range of new contributions to our understanding of the Old Tibetan language and funerary practices on the Tibetan Plateau by investigating ancient records concerned with non-Buddhist funerary rituals. In addition, the project will uncover important linguistic links to other regional language communities and will establish the first testable hypotheses about the genetic relationship of Tibetan languages. The synchronic perspective of the philological study will be complemented with historico-linguistic analysis. TOMB will specifically focus on translating documents from the Old Tibetan funerary corpus that have never been translated before. These manuscripts are remarkable for several reasons: 1) they provide insights into funerary rituals that did not survive beyond the Tibetan Empire; 2) they reflect elements of ritual culture shared with other non-Tibetan speaking groups in the region; 3), they offer evidence of earlier, pre-historical stages of the Tibetan language; and 4) they give us an opportunity to enhance our understanding of Tibetan languages and to uncover their genetic links to related languages. Through a comprehensive analysis of the corpus from both historical and text-linguistic perspectives, we will gain insights into archaisms that can be identified as features of pre-historical Tibetan. This foundational work will set the stage for reconstructing Proto-Tibetan. Identifying and describing these features will in turn contribute to the reconstruction of Proto-Bodish, the presumed ancestral language of Tibetan, East-Bodish, and Tamangic languages. The innovative approach to ritual textual sources as reservoirs of pre-historical linguistic forms tackles thus far unexplored fields of research and promises to enrich our understanding of the Tibetan non-Buddhist religious culture.

Keywords: tibetan languages bodish,sino tibetan,old tibetan,funerary practices,historical linguistics,linguistic phylogeny