Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Discovery of New Molecular Semiconductors (DINEMOS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Panel: Physical and analytical chemical sciences
Panel description: Analytical chemistry, chemical theory, physical chemistry/chemical physics
Countries involved: United Kingdom
Call: ERC Proof of Concept Grant (ERC-2019-PoC, 2019)
Start date: 2019-07-01
End date: 2021-06-30
Duration (months): 24.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

This project has two main deliverables in the area of organic electronics: (i) A database of molecular semiconductors with predicted high charge mobility. This database contains molecular materials that are characterized structurally but the vast majority of its entries are not tested or intellectually protected as molecular semiconductors. The quality of our predictions was verified in a recent paper published in Nature Materials (doi:10.1038/NMAT4970) and such database is therefore of great commercial value. (ii) A software to predict the charge mobility of newly synthesized molecular materials. Such product will help all developers of new materials to identify their best lead compounds and explore rapidly many variants. Saving time (only the most promising candidates are characterized in full) and reducing the risk of competitors taking advantage of a discovery by minor modification of a good material. The exploitation plan includes intellectual protection (patent) of the best molecules in (i) and copyright of the software (in (ii)), followed by commercialization of both.

Keywords: computed aided materials discovery
Understanding and exploiting epigenetic regulation in CAR T cell therapy (EPI-CART)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Prevention, Diagnosis and Treatment of Human Diseases
Panel description: Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
Countries involved: Austria
Call: ERC CONSOLIDATOR GRANTS (ERC-2020-COG, 2020)
Start date: 2021-12-01
End date: 2026-11-30
Duration (months): 60.0
Total project cost (EUR): 1999913.0
EU funding (EUR): 1999913.0
Participants: 1
Project status: SIGNED

The dramatic efficacy of CAR T cell therapy in certain hematopoietic malignancies provides clinical validation of a groundbreaking paradigm: Human cells can be engineered into purpose-built therapeutic agents by genetically introducing artificial regulatory programs. The EPI-CART project will focus on epigenetic regulation in CAR T cell therapy – an important but underappreciated aspect of all cell-based therapies. We will investigate the regulatory dynamics during CAR T cell therapy in unprecedented molecular detail, by following 40 patients who will receive treatment for two blood cancers (Aim 1). Using single-cell epigenome/transcriptome profiling of CAR T cells and sequential biopsies, clonal tracking, monitoring of immune regulation, and liquid biopsies, we will bioinformatically reconstruct patient-specific trajectories, identify molecular markers for therapy monitoring, and uncover epigenetic drivers of CAR T cell response. To engineer the first “epigenetically boosted” CAR T cells for hard-to-treat cancers (CAR-T-resistant blood cancers, solid tumors), we developed a CAR T cell screening/engineering platform that enables us to functionally test thousands of potential regulators in cellular assays and mouse tumor models (Aim 2). The in vivo experiments leverage our CRISPR single-cell sequencing method (CROP-seq), supporting rational optimization of CAR T cells and quantitative modeling of the underlying regulatory mechanisms. The EPI-CART project will uncover key roles of epigenetic regulation in CAR T cells, advance our understanding of existing CAR T cell therapies, and establish new approaches for areas with unmet clinical need. We will establish preclinical proof-of-concept for the efficacy of “epigenetically boosted” CAR T cells and provide a compelling rationale for subsequent first-in-human clinical trials. More generally, this project will demonstrate the biological roles and translational potential of epigenetic programs in cell-based therapy.

Keywords: car t cells,cell based therapy,immuno oncology,cancer immunotherapy,epigenomics,single cell sequencing,crispr screening,bioinformatics,personalized medicine
Photo(electro)catalytic Nitrogen Fixation (NITROGEN-LIGHT)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Italy,United States
Call: Individual Fellowships (H2020-MSCA-IF-2019, 2019)
Start date: 2021-01-01
End date: 2024-12-30
Duration (months): 36.0
Total project cost (EUR): 251002.56
EU funding (EUR): 251002.56
Participants: 2
Project status: SIGNED

Despite the intensive effort on nitrogen photofixation, there is a clear gap in the design of the catalytic system at the molecular/atomic level: at the same time, the majority of literature examples for nitrogen photo(electro)reduction employed only Uv-Vis semiconductor based systems with poor control on the molecular aspects of photo(electro)catalysis. NITROGEN-LIGHT lies in the panorama of nitrogen reduction, but offering a new point of view. This project aims to develop a photoelectrolyser to efficiently convert nitrogen to ammonia, but exploiting semiconductor surfaces decorated with controlled molecular assemblies of visible-light sensitisers and nitrogen-activating multi-redox catalysts. The advantage of the molecular design is the possibility to easily tune the redox properties of active sites and the stabilization of nitrogen-derived intermediates, with the final aim of: syncronizing photo-induced electron/proton transfer (PCET), lowering the energy barrier and optimizing the quantum efficiency. Success in this task will be instrumental for the fabrication of novel photocathodes for N2RR, to be integrated within a PEC device, in combination with photoanodes for water oxidation. The photoelectrode assembly for the final device will build on the state-of-the-art expertise and recent achievements of the CalTech and the Padova group, while frontier studies on the photophysics of selected molecular assemblies, to be performed with secondment visits at the Prague Institute, will guide the overall component choice and synthetic modification.

Keywords: nitrogen reduction,nitrogen photofixation,water oxidation,photo electro catalysis,artificial photosynthesis
Elucidating the role of ice crystal number and ice crystal size for high cloud feedbacks (ELISIR)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Reintegration panel
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Austria
Call: Individual Fellowships (H2020-MSCA-IF-2020, 2020)
Start date: 2021-07-01
End date: 2023-06-30
Duration (months): 24.0
Total project cost (EUR): 174167.04
EU funding (EUR): 174167.04
Participants: 1
Project status: SIGNED

High clouds play an important role in modulating Earth’s radiative balance by (i) reflecting shortwave radiation and (ii) preventing longwave radiation from escaping to space. These interactions with radiation also influence atmospheric circulation at all scales, from global to local. The temperature and height response of high clouds is well understood, but changes in their extent, optical depth and ice properties including ice water content, ice crystal number, and ice crystal size remain uncertain. Ice properties are important because they determine cloud radiative effects and lifetime. However, many climate models cannot interactively simulate ice crystal number and size because they use simple 1-moment microphysical schemes with ice crystal mass as the only prognostic cloud ice variable. The proposed project ELISIR will study the role of ice crystal size and number for high cloud feedbacks and dynamical responses and compare results from 1-moment with more advanced 2-moment cloud microphysical schemes, in which also ice crystal number is a prognostic variable. We hypothesize that a direct link exists between the upper tropospheric stability and the number of nucleated ice crystals, which may lead to changes in cloud optical properties and lifetime, with a significant impact on climate. The research aims will be achieved with the help of global climate model simulations and high resolution limited-domain simulations in a tropical domain, whereby each simulation will be performed once with a 1-moment and once with a 2-moment microphysical scheme. Furthermore, the CMIP6 archive will be analysed to test whether there are systematic differences in simulated cloud radiative effects between models using 1-moment and models using 2-moment microphysical schemes. This will help to better understand the drivers of high cloud feedbacks and therefore to narrow estimates of Earth’s climate sensitivity and uncertainties in the high cloud impact on the atmospheric circulation.

Keywords: high clouds,cloud feedbacks,cloud microphysics,anvil clouds,climate dynamics,climate modelling
Single-cell analysis of intestinal lymphocytes reveals targets for treatment of inflammatory bowel disease (GUT-SEQ)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Immunity, Infection and Immunotherapy
Panel description: The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies
Countries involved: Sweden
Call: ERC Starting Grant (ERC-2019-STG, 2019)
Start date: 2020-09-01
End date: 2025-08-31
Duration (months): 60.0
Total project cost (EUR): 1500000.0
EU funding (EUR): 1500000.0
Participants: 1
Project status: SIGNED

Inflammatory bowel disease (IBD) constitutes an increasing global health burden, yet effective treatments are lacking. Hampering rationale treatment strategies, the human intestinal immune system remains largely unexplored. I have made seminal contributions to the discovery and characterization of innate lymphoid cells (ILCs) (Nat Immunol 2011, 2013 and 2016, Immunity 2012), revealing that in addition to antigen-specific adaptive T cells, innate equivalents play important roles in mucosal immunity. Determining the complementarity and redundancy of these two lymphocyte systems, acting in concert, is important for our understanding of inflammatory diseases and the development of novel therapies. For this proposal, I am in the beneficial position of having access to unique patient samples as well as established methods for single-cell RNA-sequencing to perform an ambitious and comprehensive molecular dissection of the human intestinal lymphocyte compartments in IBD. With this approach, I will determine parallels between known, and identify novel, subsets of tissue-resident, inflammation-associated, innate and adaptive lymphocytes. Building on this unprecedented molecular characterization, we will take on some of the most pressing clinical problems in IBD by performing longitudinal assessments of intestinal lymphocytes from IBD patients on conventional and biological treatments. As only a fraction of patients respond to treatment, this approach provides a golden opportunity to unveil immunological signatures of treatment response and “drug-induced transformation” of inflammation in non-responders. Furthermore, we will unfold critical disease mechanisms and reveal novel therapy targets and how they can be used to personalize treatment. In summary, my ambitious, yet feasible, proposal combines state-of-the-art technology with access to unique patient materials. My studies are likely to advance our understanding of the complex intestinal lymphocyte network in IBD.
Party do not stop. Having fun with researchers (Party do not stop)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European researchers' Night
Action type: Marie Skłodowska-Curie actions
Countries involved: Italy,Italy,Italy,Italy
Call: European Researchers' Night (NIGHT) (H2020-MSCA-NIGHT-2014, 2014)
Start date: 2014-05-01
End date: 2015-12-31
Duration (months): 20.0
Total project cost (EUR): 160531.25
EU funding (EUR): 160000.0
Participants: 8
Project status: CLOSED

"Party do not stop" includes the proposal of two editions of the Researchers' Night to be carried out in Liguria in 2014 and 2015. The partnership of "Party don't stop" has decided to organize a big party where all citizens are invited on the 26th September 2014 and the 25th September 2015. The festival will take place in three cities, which together cover the entire coast of Liguria: Genoa, La Spezia and Albenga. The locations of the Night are of great interest to the general public and of great importance in the imagination of the population. The magnificent Villa Bombrini and its park in the district of Cornigliano (Genoa), the Port of Genoa, one of the main crossroads in the Mediterranean area, the Port of La Spezia, the "Giardino Letterario Delfino" (a literary garden in Albenga) and the downtown of Albenga. The partners have focused the program of the Nights on a topic: "The researchers change the world." The activities aim at attracting and involving people of any age, origin, social and cultural background in a friendly way and researchers worked in order to fully involve little girls, teen girls and women and turn them into the protagonists of the events. We really do believe that the experiments, workshops, talks, observation of stars and of sea animals, contests, sports, skill, imagination and costume competitions, cooking courses and tests, theater performances and concerts, which are planned and proposed by researchers, will make " Party do not stop " and unforgettable experience for everyone.

Keywords: entertainment,interactivities,energy saving,environmental protection,climate change
Supersolids and Beyond: Exploring New States of Matter with Laser-Cooled Dipolar Molecules (NEWMAT)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Fundamental constituents of matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2020-STG, 2020)
Start date: 2021-04-01
End date: 2026-03-31
Duration (months): 60.0
Total project cost (EUR): 1499915.0
EU funding (EUR): 1499915.0
Participants: 1
Project status: SIGNED

Quantum mechanics becomes most fascinating when its counterintuitive phenomena are observable on a macroscopic scale. The goal of this project is to realize and study novel states of matter that are paradigmatic examples of such behaviour. My primary focus is the paradoxical supersolid state of matter, which combines the crystal structure of a solid with the frictionless flow of a superfluid. The very existence of this state has been debated intensively for over 60 years. After decades of inconclusive efforts in helium, I have recently observed evidence for this state in magnetic quantum gases. This discovery has raised a plethora of new questions, which can be addressed with neither magnetic atoms nor helium, and thus require fundamentally new experimental approaches. In this project I will use laser-cooled dipolar molecules to explore supersolidity far beyond the state of the art. Starting from an ultracold gas of molecules, I will study - from few to many-body - long-discussed scenarios for supersolidity. The use of flexible optical potentials will allow me to investigate the role of doping, defects, dimensionality and disorder on the formation and dynamics of a supersolid. By using high-resolution, single-molecule imaging, I will be able to follow the corresponding dynamics down to the most elementary level, where correlations and entanglement become accessible. A particular significant generalization of this scenario arises when the spatial ordering competes with magnetic ordering. The molecules employed exhibit both electric and magnetic dipole moments and thus naturally feature the additional degree of freedom required to realize spin models. This will enable studying further exotic states of matter in which topological effects are expected to emerge. The extraordinary clean and tunable experimental approach will facilitate a precise comparison with theory, and thus promises unprecedented insights into the nature of these new states of matter.

Keywords: supersolid,quantum many body physics,ultracold molecules,laser cooling
ASSESSMENT OF ADDITIVE MANUFACTURING LIMITS FOR ECO-DESIGN OPTIMIZATION IN HEAT EXCHANGERS (AManECO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany,Spain,Germany,Spain,France
Call: Additive manufacturing boundary limits assessment for Eco Design process optimization [ECO] (H2020-CS2-CFP09-2018-02, 2018)
Start date: 2019-10-01
End date: 2023-03-31
Duration (months): 42.0
Total project cost (EUR): 1501232.5
EU funding (EUR): 1501232.5
Participants: 7
Project status: SIGNED

Selective Laser Melting (SLM) is key for improved design and production process of aviation parts. Applied to heat exchangers (HX), it could dramatically improve global eco‐efficiency through access to radically new designs and open horizons in terms of shape, weight, efficiency. Nevertheless, some questions need to be solved regarding capability of Additive Manufacturing (AM) to manufacture thin walls, small holes/gaps, low overhang angle, resulting surface roughness and mechanical strength. AManECO aims to enhance knowledge of metal AM and, specifically, the capability of SLM process to manufacture thin layers and wall thickness with adequate surface finish using AlSi7Mg0.6 and INCO 718 materials. In particular, to investigate aerothermal and mechanical performance of thin walls, to predict them in the design of AM-HX and consequently, be able to optimize the HX´s design process in an Eco-friendly way after knowing the limits of the metal AM technology. For this purpose, testing samples will be designed and manufactured to characterize in terms of surface properties, pressure resistance and gas tightness evaluation, equivalent stiffness and aerothermal properties. Besides, numerical studies based on FEM and CFD simulations will be done. Then, a representative design of HX based on the initial SOA of AM limitations will be optimized with the gained knowledge. These designs, before and after optimization, will be processed and characterized. Then, a Life Cycle Inventory (LCI) database will be created to evaluate the ECO potential of the innovative HX. AManECO will enable to: - Increase efficiency of HX up to 10%. - Reduce the overall of HX manufacturing costs by 30%. - Reduce material waste and scraps by 15 % per component. - Reduce time-to market up to 1 month. A multidisciplinary consortium, with experts in HX design and AM (TUHH, LORTEK, FIT), samples characterization (CIDETEC, MU-ENG), numerical simulation (EPSILON, TUHH), and life cycle assessment and eco-design (CTME), has been defined.

Keywords: selective laser melting,heat exchanger,eco designed data base,finite element models,aerothermal characterization,design optimization,computational fluid dynamics,life cycle inventory
Deep Forestry Drones - revolutionising forestry mapping and analysis with artificial intelligence (DFD)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Sweden
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2020-01-01
End date: 2020-04-30
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Forestry mapping is key for the economy, yet most of the mapping work is manual today, allowing assessments of only 5-10% of trees. The results of improper forestry mapping range from the inability to react to crisis events such as wildfires or diseases, lower productivity and inaccurate valuations. To solve this problem, many companies have launched mobile phone-based platforms and above canopy LiDAR or photogrammetry, but these products often come with several drawbacks, e.g. they do not provide an accurate understanding of the most desirable forestry characteristics such as wood value (quality) class, species type, volume estimation and bad wood estimates. They are also unable to provide a detailed map of the terrain (boggy areas, small streams, boulders, dead-wood, fallen trees, etc.). These drawbacks cause the existing solutions to become difficult to use and time-consuming, while providing very little added advantage over traditional methods. In turn, this forces companies to create less value and leads to smaller ROI. Deep Forestry AB built the first agile, light-weight, autonomous drone to fly below the canopy of commercial forests, that is, in-between the trees. Flying below the canopy provides our customers with analytical tools which were previously unavailable: precision analytics, robust classification algorithms, and optimized harvesting routes. They will help companies to cut their costs and increase revenue while mitigating risks and eliminating human error. Our new (Drone + AI) technology will provide more data to the front-end of the forestry value chain than has ever been thought possible. The key objective of our project is to transform an initial business plan into a robust strategy for international commercialization. With this goal in mind, our Phase 1 project will focus on a more precise market evaluation, assessing technical requirements for further scaling and optimizing our go-to-market strategy.

Keywords: drones,lidar,forest mapping,3d model