Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Molecular Mechanisms for Host-Mediated Metal Poisoning Detoxification in Mycobacterium tuberculosis (MTB-DETOX)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: France
Call: MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01, 2021)
Start date: 2022-09-01
End date: 2024-08-31
Duration (months): 24.0
Total project cost (EUR): 195914.88
EU funding (EUR): 195914.88
Participants: 4
Project status: CLOSED

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) kills 1.5 million people every year. Major challenges facing TB eradication are the lack of effective and affordable treatments, the slow pace of innovation in TB drug discovery and the emergence of antibiotics resistance. Therefore, new approaches for addressing these challenges are urgently needed. Mtb is highly adapted to survive into human macrophages which expose the bacterium to many stresses including metal ion in-toxification, whereby the host cell increases its metal ion levels resulting in inflow of metal ions into Mtb. The host laboratory has previously demonstrated that the P-ATPase transporter CtpC is part of the metal efflux system involved in zinc detoxification, which is important for Mtb survival in macrophages. Intriguingly, CtpC and two other P-ATPases are encoded together with small proteins containing a domain of unknown function named DUF1490. Unpublished data show that the DUF1490 protein encoded with CtpC binds zinc and confers zinc in-toxification tolerance to Mtb. Additionally, DUF1490 proteins co-localize with CtpC to the plasma membrane into dynamic microdomains, named “metal efflux platforms”. I propose to uncover the function of DUF1490 proteins by testing two hypotheses: 1) DUF1490 proteins are metallochaperones that facilitate the intracellular transport of metal ions to membrane transporters, and 2) DUF1490 proteins are scaffold proteins involved in P-ATPase stabilization and metal efflux platforms assembly. To explore these hypotheses, I will combine genetic, microbiology and molecular biology strategies with high-resolution optical imaging, lipidomics and proteomics. Rigorous execution of the proposed research will generate insights into the role of DUF1490 proteins in Mtb metal detoxification and pathogenicity, as well as into the novel concept of metal efflux platforms, thus yielding opportunities for TB drug development that go beyond traditional targets.

Keywords: tuberculosis,mycobacteria,metal efflux,functional membrane microdomains
Exploiting Modular Biochar and board production plants to locally transform waste from traditional agrifood, feed and forestry industries into bio-materials with rEgional DEmanD. (EMBEDED)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Other Bio-environnement destinations
Action type: Innovation actions
Countries involved: Spain,Portugal,Ireland,Czechia
Call: From silos to diversity – small-scale bio-based demonstration pilots (HORIZON-CL6-2024-CIRCBIO-02, 2024)
Start date: 2025-06-01
End date: 2028-05-31
Duration (months): 36.0
Total project cost (EUR): 6127640.0
EU funding (EUR): 4998945.89
Participants: 15
Project status: SIGNED

The EMBEDED project aims to demonstrate alternative business models in 36 months by transforming waste from Europe traditional agrifood industries into biochar and construction boards, with a long-term carbon sink effect and short resilient value chains. The validation of the km.0 application of biochar on primary producer plantations and the regional market characterization will be conducted. Valorisation streams aim to combine marginal revenues from mainstream residues (olive pomace, olive stones, grape mark) with overlooked or underutilised ones (cork bark left on field, press-cake from fresh grass, grape stems), with five demonstration pilots planned in Portugal, Ireland, Spain, and Czech Republic. Four of the pilots will have pyrolysis for the manufacture of biochar, using a modular method that fits pre- and post-conditioning phases into a single-maned portable unit. In two of the pilots, extractive methods aimed at bio-active chemicals will be evaluated to determine the added benefit of a cascade valorisation. Using a modular but stationary pilot, the Board production plant will capitalize on the cork outputs geographical. The consortium comprises 14 participants, comprising 5 SMEs and 1 LE that includes 2 technological developers and many influential figures in the agri-food industry of each designated region. In order to implement technology replications and technical transfer using the multi-actor strategy, the EMBEDED project will use 15% of the requested grant (750 k€) as financial support.

Keywords: biochar,pyrolysis plant,fertilizer,feed ingredient,cork waste,bioactive compounds
Single-shot, high repetition rate detection of the Carrier-Envelope-Phase of ultrashort laser pulses (SICEP)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Sweden,Portugal
Call: ERC PROOF OF CONCEPT GRANTS (ERC-2023-POC, 2023)
Start date: 2023-08-01
End date: 2025-01-31
Duration (months): 18.0
Total project cost (EUR): 182142.86
EU funding (EUR): 150000.0
Participants: 2
Project status: CLOSED

The interaction of short laser pulses with matter often depends on the Carrier-Envelope-Phase (CEP), which is the offset between the maximum of the electric field and the envelope of the pulse. For high-repetition-rate laser systems, this phase can usually only be measured as an average quantity. We propose a novel analog method to measure the CEP of ultrashort laser pulses in single-shot and for every laser shot at high repetition rate (hundreds of kHz to MHz). While conventional approaches use slow array detectors and computationally expensive calculations, we perform the measurement via optical Fourier transform, virtually not imposing any speed limitations. The approach also opens up for new avenues for CEP-stabilization, possibly making most of today’s complicated and expensive stabilization equipment obsolete. A patent application, securing our IP has been submitted. The project will be conducted together with our long-standing commercial partner, Sphere Ultrafast Photonics. Sphere has a strong position on the ultrafast laser market, defining an efficient path for commercialization. We plan to develop two different kinds of CEP detectors, i.e. the analog detector and a simplified digital detector working up to 100 kHz for less demanding applications. The detectors will be extensively tested and benchmarked against each other with a number of ultrafast laser sources in Lund and at Sphere. The original idea for analog CEP detection was inspired by our research in attosecond science, supported by the ERC advanced grant QPAP “Quantum Physics with attosecond Light Pulses” (884900), which requires CEP control. The lack of existing techniques for the challenging repetition rate of our laser source (200 kHz) stimulated the ideas presented in this proposal, which we now would like to explore as a proof-of-concept.
Opening new frontiers in multi-scale evolution of collider events: a dual pathway to precision (JANUS)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Fundamental Constituents of Matter
Panel description: Particle, nuclear, plasma, atomic, molecular, gas, and optical physics
Countries involved: Switzerland
Call: ERC CONSOLIDATOR GRANTS (ERC-2021-COG, 2021)
Start date: 2022-11-01
End date: 2027-10-31
Duration (months): 60.0
Total project cost (EUR): 1993125.0
EU funding (EUR): 1993125.0
Participants: 2
Project status: SIGNED

For the decades to come, the pioneering investigation of the fundamental laws of nature at the Large Hadron Collider (LHC) and at future collider experiments will rely on the interpretation of complex scattering events by means of accurate theoretical calculations, which are instrumental to find small signals of elusive new phenomena. These calculations must describe the evolution of the system from the few particles produced in the high-energy scattering to the tens or hundreds of low-energy particles observed in the detectors. This proposal aims at transforming the core of our theoretical understanding of such a multi-scale evolution, which nowadays is often too inaccurate to cope with the striking experimental precision. The goal of JANUS is to develop innovative ideas and theoretical methods to advance significantly both approaches to the problem: Resummations and Parton-Shower-Monte-Carlo (PSMC) generators. JANUS will establish a deep connection between the two fields, resulting in novel technology for the accurate modelling of multi-scale effects. Its main objectives are: - To formulate new theoretical methods to tackle the resummation of complex collider observables in reactions with more than two emitters and scales with state-of-the-art accuracy. - To lay the theoretical foundations for a new generation of PSMC algorithms, capable of describing accurately the hard scattering and subsequent parton-shower evolution for reactions with different jet multiplicities with a new standard of precision. This technology will be applied to obtain state-of-the-art theoretical predictions for a broad range of critical observables in the important fields of Higgs and jet physics, enabling their optimal exploration at the LHC and future collider experiments.

Keywords: perturbative qcd,resummation,parton showers,event generators,collider phenomenology
Fostering agroecology transition in North Africa through multi-actor, evaluation, and networking (NATAE)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Food, Bioeconomy Natural Resources, Agriculture and Environment
Theme: Bio-Environment
Destination: Fair, healthy and environmentally-friendly food systems from primary production to consumption
Action type: Research and Innovation actions
Countries involved: France,Tunisia,Greece,Italy,Germany,Netherlands,Morocco,Portugal,Algeria,Libya,Lebanon,South Africa,Switzerland,Mauritania
Call: Agro-ecological approaches in African agriculture systems (HORIZON-CL6-2022-FARM2FORK-01, 2022)
Start date: 2022-12-01
End date: 2026-11-30
Duration (months): 48.0
Total project cost (EUR): 6999185.01
EU funding (EUR): 6999185.01
Participants: 24
Project status: SIGNED

Transforming agriculture in the context of climate change is a central challenge in North-Africa, the most food-import-dependent region worldwide and a climate change hotspot. Tackling these issues, Agro-Ecology (AE) appears as an answer to meet both the challenges of global sustainability and local resilience. In this context, NATAE consortium brings together high-level research institutions, international organisations and NGOs with strong experience on AE approaches and exceptional capacity to induce transformational change by informing policies and education. NATAE project aims to foster the adoption of science-based, locally-tailored and co-designed AE strategies in North Africa by creating a comprehensive and quantitative baseline on AE, providing a shared understanding, multidimensional performance measures, and analyses of AE potential for meeting consumers demand on the market. To achieve this goal, NATAE will set-up and inform a unique multi-actor community of knowledge and capacity building on AE in the Mediterranean, with ground breaking findings on the performances of AE-Practices (AEP) in North Africa. An original multi-dimensional, multi-scale evaluation framework covering dimensions currently overlooked, and a replicable methodological guidebook will be designed. An integrated modelling approach combining a biophysical, a household/regional bio-economic indicator modelling chain will be used to develop a unique Integrated Assessment of Agricultural Systems to assess the resilience of AEP-based farming systems. Participatory approaches via Living Labs will be elaborated to develop, test and capitalize alternative public policies and foster AE transitions. An integrated group of dissemination activities, will further test, advance and communicate a range of existing AE innovations from farm to fork, including innovative farm practices, value-chain innovations, and innovations in food system governance, advancing their respective readiness level.

Keywords: bio economic modelling,living lab,participatory approaches
Mesoscopic light-matter entanglement in hybrid solid-state networks (enQnet)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Physics
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-10-01
End date: 2026-09-30
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

Hybrid quantum systems couple together multiple distinct physical degrees of freedom. They are essential to the quantum technological revolution as, for instance, the light-matter coupling provides a way to transfer information from electronic to optical systems or vice versa. They also allow studying fundamental physics of quantum information. I propose a theoretical project involving hybrid quantum networks consisting of coupled photonic and electronic systems. It will lead to a state-of-the-art blueprint for a quantum simulator and a set of new tools for understanding quantum mechanical entanglement in practice. Currently, there are efforts to build quantum computers and simulators. These systems are often based on superconducting circuits or trapped ions with one type of a system: a qubit which is a two-level system. However, simulating modes with multiple levels, optical or vibrational systems for example, is inefficient with qubits. This project aims to provide novel theoretical tools for a hybrid quantum network that would fare better because it already contains optical modes. The theoretical tools developed combine condensed matter physics and quantum optics including phase-space methods. I tackle the scientific objective in the following way: First, I focus on specific light-matter interactions of quantum dots and microwave cavities. I look into the smallest possible network of a quantum dot coupled to two cavities. In this simple network, I characterize the non-classical and non-local correlations of the two cavities, their entanglement, by studying the cross-correlations of the photons emitted by the cavities. Second, I expand the network by connecting quantum dots to the two cavities. This allows seeing the propagation of entanglement from the cavities to the terminating quantum dots. Finally, I extend the investigations to large hybrid networks which I will use for quantum simulation and to find new effective descriptions of entanglement propagation.
Understanding Under Uncertainty: Symbiotic Relations Between the Storyline Approach and the Philosophy of Scientific Understanding (UN3)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Social Sciences and Humanities
Countries involved: Italy,Netherlands
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2023-12-20
End date: 2025-12-19
Duration (months): 24.0
Total project cost (EUR): 172750.08
EU funding (EUR): 172750.08
Participants: 2
Project status: SIGNED

In the last decade, the "storyline" approach has been introduced and developed in the subfield of attribution and detection in climate studies. In spite of its merits, it has been met with harsh criticism, especially from advocates of probabilistic approaches. The overall aim of UN3 is to explore and exploit the symbiotic relations between the storyline approach and the philosophy of scientific understanding, to foster the legitimation of the former and advance internal philosophical debates in the latter. UN3 is organized into three research work packages with a specific objective. WP1 investigates the "factivity" of storyline-based understanding. Its specific objective is to characterize and evaluate storyline-based scientific understanding, emphasising its complementarities with and divergences from probabilistic understanding, particularly in terms of their factivity. WP2 investigates the "effectiveness" of storyline-based understanding. Its specific objective is to assess the effectiveness/factivity ratio of storyline-based understanding in successful decision-making under deep uncertainty, particularly in terms of informing robust and/or adaptive strategies and exploiting their relations. WP3 investigates the "transdisciplinarity" of storyline-based understanding. Its specific objective is to identify, characterize, and develop transdisciplinary means in which storyline-based understanding may be advanced by local knowledge and, in turn, advance epistemic justice in climate science, particularly in terms of conveying actionable knowledge. The overall methodology is inter- and transdisciplinary, involving theoretical and empirical components, and including collaborations with academic researchers from various centres and with non-academic stakeholders. UN3 will be conducted at Politecnico di Milano with Prof. Giovanni Valente as supervisor and Prof. Massimo Tavoni as co-supervisor. A secondment is planned at TU Delft, with Prof. Behnam Taebi as host.

Keywords: storylines,scientific understanding,deep uncertainty,scientific representations,decision making,epistemic justice,inter and trans disciplinarity
Machine learning for diagnosis of bipolar disorder: detection of physiological digital biomarkers (AI-DIAGNOSE)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Spain,Israel
Call: MSCA Postdoctoral Fellowships 2022 (HORIZON-MSCA-2022-PF-01, 2022)
Start date: 2024-01-01
End date: 2026-03-31
Duration (months): 27.0
Total project cost (EUR): 181152.96
EU funding (EUR): 181152.96
Participants: 2
Project status: SIGNED

Bipolar disorder (BD) is a chronic and debilitating mental disorder, that affects 2-3% of the population. It impacts quality of life, cognition, and is a leading cause of suicide and all-cause mortalities. Most patients are taken into clinical care during acute episodes, which puts the burden on psychiatrists to make fast, yet accurate diagnostic decisions. However, unlike most medical conditions, psychiatric diagnoses are subjective. This paired with the complexity of its clinical presentation, BD is the most misdiagnosed and underdiagnosed psychiatric condition. More objective scales used in research lack clinical application, due to time constraints and high burden on the patient. AI-DIAGNOSE wants to disrupt the state of the art of BD diagnosis through a completely novel approach: developing an automatized and fast tool for objective detection of BD and psychotic symptoms based on physiological audiovisual biomarkers and machine learning (ML). The timing of the project is supported through recent evidence, from the host, the applicant, and others, showing that speech and eye movement are promising physiological biomarkers. In a pilot study, I found that ML algorithms based on speech patterns could predict the presence of psychiatric diagnosis, and differentiate patients with and without psychosis. Eye‐tracking datasets provide insights regarding information processing patterns, and have shown potential as diagnostic biomarkers. Although eye movement and speech patterns are promising biomarkers as they can be acquired fast and without putting high burden on the patient, they have not been combined yet for psychiatric diagnostic purposes. The project will be the first to develop such a multi-modal ML diagnostic tool for BD and psychosis in BD. We will test its accuracy against the research gold standard in the field within a large patient cohort (140 patients, 70 controls). If successful, this will a major step towards precision medicine within BD and psychiatry

Keywords: psychiatric diagnosis,bipolar disorder,digital biomarkers,psychotic symptoms,speech analysis
Relativistic Jets in the Multimessenger Era (MultiJets)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Israel
Call: ERC ADVANCED GRANTS (ERC-2021-ADG, 2021)
Start date: 2022-10-01
End date: 2027-09-30
Duration (months): 60.0
Total project cost (EUR): 2498750.0
EU funding (EUR): 2498750.0
Participants: 1
Project status: SIGNED

The birth of multimessenger Astronomy is unfolding in front of our eyes, largely thanks to incredible observational developments. The new observations challenge theory on numerous frontiers and my goal is to address some of those and to open others. Relativistic jets are the classical multimessenger sources, typically dominating the observed signature of the objects that launch them. Relativistic jets even have their own gravitational waves signature, Jet-GW, that arises from the jet acceleration. This signal, largely ignored so far, is a memory type wave that enable us to “see” directly the jet launching process, and is probably the only way to do so. Detection of Jet-GWs is extremely challenging and they may be easily missed if they are not looked for. In this program, I aim to achieve the understanding of these signals essential for their detection. In addition I propose to explore observational implications of relativistic jets as they are manifested in binary neutron star mergers (BNS), gamma-ray bursts (GRBs) and a subpopulation of supernovae (SNe) that harbor hidden jets, and tidal disruption events (TDEs). I will study the basic physics involved, carry out large scale simulations and probe new observational results. I will focus on new physics, for example photodissociation of heavy nuclei during jet propagation within BNS ejecta, that hasn’t been considered so far. Powerful jets appears in some TDEs, but not in others. This makes TDEs natural laboratories to pursue the major open question: under which conditions are powerful jets launched? Although BNS, GRBs, SNe and TDEs appear to be very different, their jets have a lot in common. Understanding them requires analysis of the same basic physics and application of similar numerical tools. This joint study that breaks artificial conceptual barriers will be highly beneficial and fruitful.