Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
SINGLE-MOLECULE DNA SEQUENCING THROUGH DNA ORIGAMI NANOANTENNAS. (Origami-SEQ)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany,Germany
Call: Individual Fellowships (H2020-MSCA-IF-2016, 2016)
Start date: 2017-04-01
End date: 2019-03-31
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 2
Project status: CLOSED

The inner working of many fundamental biological nanomachines implies many stochastic changes in conformation and molecular interactions. These changes are reflected as variability in the activity of the same molecule over time, and in heterogeneous activities between different molecules. By the direct observation at the molecular scale of these nanomachines activity, single-molecule fluorescence techniques have gained access to this stochastic information, which is otherwise missed by bulk techniques but is essential for their understanding. However, the widespread use of these techniques in many biological systems has been hampered by the low working concentration (nM) determined by the diffraction limit of light, and current nanophotonic solutions to this problem are technically too demanding. Here, we propose self-assembled DNA origami nanoantennas as nanophotonic platforms aiming to break this concentration barrier by means of fluorescence signal enhancing and reduction of the observation volume. The versatility of DNA origami structures, biocompatibility and ability for site-directed immobilization of biomolecules, make them perfectly suited to perform complex biological assays. In the presented action we aim to achieve single-molecule fluorescence DNA sequencing using DNA origami nanoantennas to probe the potential of these platforms to perform complex bioassays, in the high concentration regime and demanding multiplexing. Moreover, since they avoid the fabrication and instrumental challenges related to other nanophotonic devices, self-assembly DNA origami nanoantennas are amenable, easy to handle and friendly technology to the biological experimenter, and thus we expect to boost their use in biology. Besides, the fulfilment of this action will provide the fellow with a complete formative training that would boost his future scientific career, and will generate also a new DNA-sequencing technology that will impact positively European scientific excellence.

Keywords: single molecule fluorescence,dna origami,optical nanoantennas,nanophotonic devices
Bilateral Coordination for the Enhancement and Development of STI Partnerships between the EU and the USA (BILAT USA 4.0)

Framework: Horizon 2020 — Societal Challenges
Programme: Europe in a changing world - inclusive, innovative and reflective societies
Action type: Coordination and support actions
Countries involved: Austria,Italy,Germany,Switzerland,Greece,Hungary,France,United States,Luxembourg,Portugal
Call: Enhancing and focusing research and innovation cooperation with the Union’s key international partner countries - proposals targeting Australia, USA, Brazil, South Africa, Ukraine (H2020-INT-INCO-2015, 2015)
Start date: 2016-02-01
End date: 2019-03-31
Duration (months): 38.0
Total project cost (EUR): 2427306.52
EU funding (EUR): 1949995.63
Participants: 17
Project status: CLOSED

The EU and the USA have highly-productive, immensely-innovative and excellence-driven research and innovation systems. Acknowledging the particular strengths of each landscape, a balanced transatlantic STI partnership of equals bears great potential and contributes to the ultimate goal of tackling societal challenges and boost economic competitiveness. International cooperation between power nodes results in a constant knowledge exchange and more efficient use of STI investment. BILAT USA 4.0’s targeted transatlantic activities work towards: i) Strategic priority setting for EU-US cooperation through identifying emerging STI fields with a high benefit and added value from cooperation, thus providing evidence-based input for policy decision-making ii) Stronger interaction between EU and US researchers through thematic events promoting funding opportunities on both sides and thus strengthening the quality and quantity of partnerships between STI actors in EU MS/AC and the USA iii) Establishing optimal framework conditions through proposing concrete solutions for eliminating cooperation obstacles deriving from researchers’ and innovators’ feedback, thus, creating an environment that favors joint solutions for global challenges iv) Enhanced coordination and synergies between different policies through analyzing EU, MS/AC and US programmes and detection of duplications, thus, contributing to a greater coherence, joint ownership and resource efficiency v) Ensuring close synergies with calls launched in H2020 and their int. dimension through screening of US-targeted actions in H2020 and liaising with relevant (ERA) projects to guarantee a consistent information exchange Ensuring sustainability, project activities build on former and liaise with existing initiatives. Relevance and exploitation of project actions will be assured by a close coordination with the EC. The project will pursue a targeted communication connecting the diverse range of EU-US STI stakeholders.
Negative capacitor based on a ferroelectric nano-dot (NegCap)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: Israel
Call: ERC-Proof of Concept (ERC-2017-PoC, 2017)
Start date: 2018-05-01
End date: 2019-10-31
Duration (months): 18.0
Total project cost (EUR): 150000.0
EU funding (EUR): 150000.0
Participants: 1
Project status: CLOSED

One of the most exciting proposed solutions to the approaching limit of down-scaling in microelectronics (so-called “end of Moore’s law”) consists of the use of negative capacitors, [NegCap]s. When a NegCap is placed between the gate and the channel of a FET (field-effect transistor), the applied voltage on the gate is strongly amplified on the channel. Therefore, it is possible to reduce substantially the applied gate voltage, yet keeping the voltage on the gate sufficiently high for on/off switching of the FET. To continue the scaling down of basic electronic components such as FET, reduction of the applied voltage is essential in order to avoid overheating due to the too high power dissipation in the ultra high-density circuits. On the other hand, due to fundamental laws of physics, a minimum voltage of 60mV/decade is necessary for operation of the FET with currently available technologies. A way to solve these conflicting needs is to reduce the gate voltage and in parallel use a NegCap that will amplify the voltage on the channel. But how to get a negative capacitor? In 2008 Salahuddin and Datta proposed to make NegCap using a ferroelectric capacitor. However, so far, experimental attempts failed to show the stable negative capacitance necessary for the voltage amplification on the FET gate. The key problem is that the ferroelectric splits into domains, which cancels the stabilized negative capacitance effect. In our ERC-AdG project (“MOBILE-W”), we conceived a concept, supported by theory and modelling, that allows the fabrication of negative capacitors in which splitting to domains is prohibited. Here we aim to demonstrate this experimentally providing proof of concept, and find suitable framework and partners to translate our concept into commercial products. We believe that this will solve one of the major road-blocks for further scaling down of microelectronic circuits.

Keywords: negative capacitance,ferroelectrics,transistor,nc fet
North Atlantic Fisheries: An Environmental History, 1400-1700 (NorFish)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: The study of the human past
Panel description: Archaeology, history and memory
Countries involved: Ireland
Call: ERC Advanced Grant (ERC-2014-ADG, 2014)
Start date: 2016-01-01
End date: 2021-06-30
Duration (months): 66.0
Total project cost (EUR): 2499265.0
EU funding (EUR): 2499265.0
Participants: 1
Project status: CLOSED

NorFish aims to understand the restructuring of the North Atlantic fisheries, fish markets and fishery-dependent communities in the late medieval and early modern world. The project exploits a multi-disciplinary, humanities-led approach to marine environmental history, assessing and synthesizing the dynamics and significance of the North Atlantic fish revolution, equipped by methodological advances in which the PI has been to the fore in delivering. It establishes a robust quantitative framework of extractions, supplies and prices, while also charting the qualitative preferences and politics that motivated actors of the fish revolution across the North Atlantic. Fish contributed to environmental and societal change in the North Atlantic for over 300 years, shifting from being a high-priced, limited resource in the late Middle Ages to a low-priced, abundant one by early modern times. Conditioned by market forces, the ‘fish revolution’ of the 1500s and 1600s reshaped alignments in economic power, demography, and politics. With acute consequences in peripheral Atlantic settlements from Newfoundland to Scandinavia, it held strategic importance to all the major western European powers. While the fish revolution catalysed the globalization of the Atlantic world, we lack adequate baselines and trajectories for key questions of natural abundance, supply and demand, cultural preferences, marketing technologies, plus national and regional strategies. In short, the core questions are what were the natural and economic causes of the fish revolution, how did marginal societies adapt to changing international trade and consumption patterns around the North Atlantic, and how did economic and political actors respond? The answers will help explain the historic role of environment and climate change, how markets impacted marginal communities, and how humans perceived long-term change.

Keywords: environmental history
Leveraging the antioxidant role of volatile isoprenoids for improving grapevine resistance to ozone and temperature stress (OVOC)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Global Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Italy,United States
Call: Marie Skłodowska-Curie Individual Fellowships (IF-GF) (H2020-MSCA-IF-2014, 2014)
Start date: 2015-08-01
End date: 2018-07-31
Duration (months): 36.0
Total project cost (EUR): 244269.0
EU funding (EUR): 244269.0
Participants: 2
Project status: CLOSED

The first aim of the project is to prove a general mechanism for plant protection from abiotic stresses (such as temperature and ozone stress) exerted by volatile isoprenoids (VIPs). Recent studies advanced the hypothesis that VIPs may function as effective antioxidants in plants by directly reacting with reactive oxygen species (ROS) that accumulate upon abiotic stress, producing oxidized VIPs. However, this mechanism is yet to be confirmed. During the outgoing phase (Harvard University, Cambridge MA, USA) the objective described above will be addressed via a comprehensive experimental approach that will be carried out on the model plant Arabidopsis (wild-type and isoprene-emitting transgenic Arabidopsis), on a plant species (Quercus rubra) that emits very large quantities of VIPs and on grapevine, a crop of outmost importance in the European economy. During the return phase (FEM, Trento, Italy) the multidisciplinary expertise gained in the outgoing period will be fully employed to study the grapevine germplasm owned by the return institution and new grapevine varieties selected or genetically modified for the emission of specific VIPs, which have recently been developed by a partner research group, in collaboration with the applicant. The final objectives of the project are 1) to prove that VIPs act as effective antioxidant on grapevine leading to an improved ozone stress resistance and 2) to integrate screening for VIP emission in the host institution grapevine breeding program in order to improve stress resistance of new grapevine varieties.

Keywords: volatile isoprenoids,antioxidant,plants,grapevine
Algebraic Methods for Stronger Crypto (ALGSTRONGCRYPTO)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Computer science and informatics
Panel description: Informatics and information systems, computer science, scientific computing, intelligent systems
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2016-ADG, 2016)
Start date: 2017-10-01
End date: 2022-09-30
Duration (months): 60.0
Total project cost (EUR): 2447439.0
EU funding (EUR): 2447439.0
Participants: 2
Project status: SIGNED

Our field is cryptology. Our overarching objective is to advance significantly the frontiers in design and analysis of high-security cryptography for the future generation. Particularly, we wish to enhance the efficiency, functionality, and, last-but-not-least, fundamental understanding of cryptographic security against very powerful adversaries. Our approach here is to develop completely novel methods by deepening, strengthening and broadening the algebraic foundations of the field. Concretely, our lens builds on the arithmetic codex. This is a general, abstract cryptographic primitive whose basic theory we recently developed and whose asymptotic part, which relies on algebraic geometry, enjoys crucial applications in surprising foundational results on constant communication-rate two-party cryptography. A codex is a linear (error correcting) code that, when endowing its ambient vector space just with coordinate-wise multiplication, can be viewed as simulating, up to some degree, richer arithmetical structures such as finite fields (or products thereof), or generally, finite-dimensional algebras over finite fields. Besides this degree, coordinate-localities for which simulation holds and for which it does not at all are also captured. Our method is based on novel perspectives on codices which significantly widen their scope and strengthen their utility. Particularly, we bring symmetries, computational- and complexity theoretic aspects, and connections with algebraic number theory, -geometry, and -combinatorics into play in novel ways. Our applications range from public-key cryptography to secure multi-party computation. Our proposal is subdivided into 3 interconnected modules: (1) Algebraic- and Number Theoretical Cryptanalysis (2) Construction of Algebraic Crypto Primitives (3) Advanced Theory of Arithmetic Codices

Keywords: cryptology,public key cryptography,secure computation,algebraic methods
Ground-breaking roof tile solution for solar energy collection (TilePlus)

Framework: Horizon 2020 — Industrial Leadership
Action type: Innovation actions
Countries involved: Germany,Sweden,Norway,Denmark
Call: Fast Track to Innovation (FTI) (H2020-EIC-FTI-2018-2020, 2020)
Start date: 2021-06-01
End date: 2023-11-30
Duration (months): 30.0
Total project cost (EUR): 3331071.38
EU funding (EUR): 2430749.95
Participants: 5
Project status: SIGNED

The overall objective of the project is to mature, qualify and enable a swift market launch and scale-up of our revolutionary solar roof technology with the overarching aim to become the new reference for solar roof technology in Europe and beyond. Our disruptive E-Tile+ solution is the first solar system made of real roof tiles, having the same size, shape and appearance as normal roof tiles. These features, in contrast to standard solar panels or tiles, entail high ease of installment (40% lower installation time), reliability (i.e. 30% higher lifetime and lower maintenance costs) and safety (<120V operations vs. 400V), as well as increased exploitation of available roof area (30% more). With E-Tile+, 20-30 million roofs across the EU, which cannot be served with standard solar panels today, could be targeted to harvest solar energy. Furthermore, our unique and patented tiles contacting approach (plug-and-play and parallel connection) provides more power output (20% higher conversion efficiency) than today’s solar panels. The latter are connected in-series and thus suffer from shadow effects, high additional costs and danger (high-voltage operations that require specially qualified electricians). Hence, E-Tile+ is a solar system specifically designed for the needs of construction companies, complying with upcoming energy regulations and solving the current issues of traditional PV roof panels. This FTI project will mature E-Tile+ in terms of performance, manufacturing cost, production yield and ensure full qualification of our product for its launch in our target markets, with a Business Plan adapted to guarantee a fast and sustained market entry. TilePlus project will address the solar roof market.

Keywords: solar tiles,solar laminates,residential house roofs,public buildings,parallel circuit,concrete tiles,building integrated photovoltaic,carbon neutrality,renewable energy,energy administration
Over-The-Counter Test Strip for Early-Stage Cancer Screening (BiomStrip)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Hungary
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-07-01
End date: 2019-12-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Cancer is the second leading cause of death globally, causing 1 in 6 deaths. If cancer is diagnosed at early stage, it is highly likely to be treated successfully. Once it has grown and spread, therapy is vastly more difficult and costly, and survival rate drops rapidly. Screening is a vital healthcare element for early detection but suffers from burdens of cost, capacity, compliance, and detection sensitivity problems. BiomStrip introduces a pioneering screening solution that can carry out cancer screening in the fashion of the common pregnancy tests. Building on our recent breakthrough results in biomarker validation granting TRL6 stage, we have designed a diagnostic device that is low-cost, non-invasive, accurate, can be handled by consumer, and bought over-the counter. The diagnostic method is based on detecting dysbiosis of gut microbial flora, a highly sensitive indicator of pathophysiological processes able to selectively show disease onset at super-early stage, even before histological changes are observable. The method is ultimately able to detect most cancer types and even other diseases, making it a future platform technology. For highest scalability, fastest time-to-market, explosive growth, low resource-intensity, and minimised risk and overheads, we will license production and commercialisation to established multinational companies, keeping our focus as high-tech SME. Breast cancer will be our market entry point and other diseases will be covered subsequently form own resources. To engineer this Workplan, a feasibility study will assess entry use cases and their markets, analyse business model and partnership options, and evaluate IPR strategies in a Strategic Business Plan. The disruptive approach offers to transform cancer screening from top-down to bottom-up: empowering patients, gradually alleviating healthcare systems large effort and sums spent on preventive cancer diagnostics, and drastically improving therapeutical effectiveness.

Keywords: breast cancer,screening,diagnostics,dysbiosis,biomarker,licensing
Middleware for collaborative Applications and Global vIrtual Communities (MAGIC)

Framework: Horizon 2020 — Excellent Science
Programme: Research Infrastructures
Theme: Research infrastructures
Destination: Support and infrastructures
Action type: Coordination and support actions
Countries involved: Germany,Ecuador,South Africa,Uruguay,Greece,Grenada,Hungary,Korea, Republic of,Colombia,France,Czechia,Netherlands,Netherlands,Kyrgyzstan,Chile,Ghana,Mexico,Brazil,United Kingdom
Call: e-Infrastructure policy development and international cooperation (H2020-INFRASUPP-2014-2, 2014)
Start date: 2015-05-01
End date: 2017-04-30
Duration (months): 24.0
Total project cost (EUR): 1821872.5
EU funding (EUR): 1355972.0
Participants: 22
Project status: CLOSED

The MAGIC Project seeks to establish a set of agreements for Europe, Latin America and other participating World Regions, aiming at consolidating and completing the building blocks of middleware necessary for the establishment of a marketplace of services and real-time applications for international and inter-continental research groups which facilitates mobility and the work of global science communities. More specifically, the project specific goals are: -To foster the deployment of the platforms that enable mobility of people and seamless access to services by promoting the establishment of identity federations interconnected via eduGAIN, creating awareness of privacy and security issues and spreading eduroam by: sharing experiences, carrying out training and making available shared infrastructure to ease the process in the partner world regions. -To develop a model for inter-operation between NREN cloud application markets of participating world regions, based on cloud provisioning and taking advantage of applications developed and run by NRENs across different continents to create a model for a worldwide application market for collaboration tools and services -To seek consensus among participating world regions on the importance of interoperability of real-time applications and work towards the adoption of standards such as those proposed by the Global CEO Forum to promote the creation of a worldwide environment for these applications. -To foster the collaborative work of Global Science Communities by actively promoting the participation of Latin American and other regions’ researchers in European Commission Calls and those of other international funding agencies with high impact in the participating regions and other networking activities.

Keywords: eduroam,edugain,cloud computing,collaboration,virtual communities