Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Full Fairing Rotor Head Aerodynamic Design Optimization (FURADO)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Innovation actions
Partnership: CS2 (Art-187)
Countries involved: Germany
Call: Aerodynamic and functional design study of a full-fairing semi-watertight concept for an articulated rotor head (H2020-CS2-CFP01-2014-01, 2014)
Start date: 2016-03-01
End date: 2020-02-29
Duration (months): 48.0
Total project cost (EUR): 399000.0
EU funding (EUR): 399000.0
Participants: 1
Project status: CLOSED

The project is aimed on the numerical design optimization and flow analysis of a semi-watertight full fairing rotor head with respect to drag reduction of a compound helicopter configuration, namely the Low Impact, Fast and Efficient Rotorcraft (LifeRCraft) demonstrator. It has been shown that fully fairing the structural components of the rotor head as a whole provides significant drag reduction potential. The project first phase concentrates on the method development for all consecutive steps. This includes enhancing the existing CFD and optimizer software to be able to automatically optimize the fairing geometries. The software functionality is demonstrated by performing computations of the rotor head blade sleeve fairings, the full-fairing beanie and the pylon fairing for a series of simplified flow conditions. The second phase of the project is dedicated to pre-development of potential rotor head full fairing configurations. A special focus is on preliminary optimisations of the blade sleeves, beanie and hub fairing for forward flight conditions with a non-spinning rotor head. The following development phase addresses two tasks. The first task comprises a refined aerodynamic optimization of promising full fairing configurations under the effect of rotor rotation. Flow conditions inside the fairing are also thermically analyzed to avoid any overheating of components. The second task is on wake flow analysis of the drag-reducing full fairing geometries performing high precision aerodynamic simulations. Strong unsteady airloads on the empennage due to the rotor head wake must be avoided to ensure proper flight dynamics and structural integrity. Consequently, the project results in a seamless integration of the developed software tools into the topic leaders work flow. The complex, CPU-intensive CFD simulations establish a sound data base for full fairing rotor head design and analysis which is not available today.

Keywords: semi watertight full fairing rotor head,drag reduction,numerical optimization,numerical analysis,mechanical design
smart childhood Obesity CARing solution using IoT potential (OCARIoT)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: Research and Innovation actions
Countries involved: Spain,Spain,Greece,Greece,Portugal
Call: IoT Pilots (H2020-EUB-2017, 2017)
Start date: 2017-11-01
End date: 2021-04-30
Duration (months): 42.0
Total project cost (EUR): 1553402.5
EU funding (EUR): 1553402.5
Participants: 7
Project status: CLOSED

Child obesity is the major pediatric public health concern, affecting around 224 million school-age children in the world. Its prevalence has tripled in many European countries since 1980, increasing in an alarming rate. Childhood obesity already affects more than one in three school-aged children in Brazil, Greece and Spain. The main goal of OCARIoT is to promote the improvement of eating and physical disorders and also the prevention of the obesity onset for children (between 9 and 12 years old). For doing so, OCARIoT will develop an IoT-based personalised coaching solution guiding children to adopt healthy eating and physical activity behaviour. The IoT network will allow observing child activity patterns of daily living, health evolution, physiological & behavioural parameters and environmental data. All this information combined with medical patterns will allows OCARIoT to provide a customised obesity coaching plan while enabling children to remain active and engaged in their well-being and healthy habits management. The proposed solution will be able to empower children (and also educational staff and families) in taking control of their health by collecting real-time information about nutrition and physical activity, and interconnecting doctors and children (including parents and tutors) in order to adapt the individual obesity coaching plan. OCARIoT will demonstrate and validate its results on three specific pilot sites in Spain, Greece and Brazil. The OCARIoT consortium will ensure children’s rights and data privacy, security and confidentiality through an Ethics Board composed by healthcare professionals and children representatives from different EU and Brazil organisations.

Keywords: iot pilot,childhood obesity,smart assisted living and wellbeing,iot data acquisition,ot data monitoring
The mammalian intracellular response to Microsporidia infection (MicroMAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2019-07-01
End date: 2021-12-25
Duration (months): 24.0
Total project cost (EUR): 195454.8
EU funding (EUR): 195454.8
Participants: 1
Project status: CLOSED

Cellular protein homeostasis (proteostasis) is central to health and disease status. It depends on complex regulatory networks of two major interconnected proteolytic degradation pathways: the ubiquitin-proteasome (UPS) and autophagy systems. Here we will investigate whether a novel proteostasis pathway, called the Intracellular Pathogen Response (IPR), recently identified in the model system Caenorhabditis elegans, is also active in mammalian cells. In C. elegans the IPR is upregulated during infection by Microsporidia, a highly successful group of obligate intracellular parasites that infect a broad range of invertebrates and mammals, including humans. Very little is currently known about mammalian intracellular responses to Microsporidia infections. The objective of the project is to dissect the mammalian proteostasis response to Microsporidia infections and compare it to the IPR from C. elegans. To accomplish this a multidisciplinary approach combining genetics, cell biology and proteomics will be applied to Microsporidia-mammalian models developed in the host lab. The proposal involves a promising French researcher with a background in invertebrate parasitology and host responses to infection, moving to a host laboratory in Newcastle, UK, noted for excellent training of young researchers, and for its research on Microsporidia molecular cell biology. Training in analysing Microsporidia infection dynamics in mammalian cells will be supported by host training in dissecting cellular proteostasis pathways to synergistically complement the skills of the researcher in invertebrate parasitology. The project will equip the researcher with strong expertise in molecular cell biology from a comparative perspective. It will also deliver the first detailed insights into the mammalian UPS/autophagy response to Microsporidia infection, with general implications for understanding mammalian proteostasis in health and disease.

Keywords: autophagy,ubiquitylation,cell biology,virus,proteomics
Accelerating Innovation in Microfabricated Medical Devices (Moore4Medical)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Austria,Germany,Germany,Spain,Spain,Ireland,Italy,Italy,Italy,Austria,Austria,Germany,Germany,Germany,Ireland,Italy,Italy,Germany,Spain,Germany,Germany,Germany,Spain,Spain,Finland,Switzerland,Belgium,Finland,Switzerland,Hungary,Romania,Switzerland,Finland,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Netherlands,Portugal,Portugal,Portugal,Portugal
Call: ECSEL-2019-1-IA (H2020-ECSEL-2019-1-IA, 2019)
Start date: 2020-06-01
End date: 2023-09-30
Duration (months): 40.0
Total project cost (EUR): 65224154.71
EU funding (EUR): 16869773.21
Participants: 68
Project status: SIGNED

Compared to the pace of innovation in electronic consumer products, the pace of innovation for medical devices is lagging behind. It is the overarching objective of Moore4Medical to accelerate innovation in electronic medical devices. Moore4Medical emerging medical applications that offer significant new opportunities for the ECS industry including: active implantable devices (bioelectronic medicines), organ-on-chip, drug adherence monitoring, smart ultrasound, radiation free interventions and continuous monitoring. The new technologies will help fighting the increasing cost of healthcare by: reducing the need for hospitalization, helping the development of personalized therapies, and realizing intelligent point-of-care diagnostic tools. Moore4Medical will bring together 68 specialists from 12 countries who will develop open technology platforms for these emerging fields to help them bridge “the Valley of Death” in shorter time and at lower cost. Open technology platforms used by multiple users for multiple applications with the prospect of medium to high volume markets are an attractive proposition for the European ECS industry. The combination of typical MedTech applications with an ECS style platform approach will enhance the competitiveness for the emerging medical domains addressed in Moore4Medical. With value and IP moving from the technology level towards applications and solutions, defragmentation and open technology platforms will be key in acquiring and maintaining a premier position for Europe in the forefront of affordable healthcare

Keywords: open and enabling technology platforms
Predicting Routes Of Tumour Evolution driven by Unstable genomes and Selection (PROTEUS)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Physiology in Health, Disease and Ageing
Panel description: Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, interorgan and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)
Countries involved: United Kingdom
Call: ERC Advanced Grant (ERC-2018-ADG, 2018)
Start date: 2019-06-01
End date: 2024-11-30
Duration (months): 66.0
Total project cost (EUR): 2500000.0
EU funding (EUR): 2500000.0
Participants: 1
Project status: SIGNED

Despite progress in cancer drug development, the majority of patients who present with advanced, metastatic, solid tumours have incurable disease due to underlying cancer genomic diversity that provides a substrate for evolution and selection of drug resistance. The aim of this proposal is to describe, synthesise and model the micro- and macroevolutionary patterns of genomic instability underpinning the evolutionary dynamics of tumour life histories, to improve patient stratification, treatment and survival outcomes. Longitudinal clinical studies such as TRACERx are highlighting the complex processes that generate this intra-tumour heterogeneity (ITH). Genome Instability (GIN) describes aberrant changes within the genome, encompassing genome doubling (GD), numerical or structural chromosomal instability (CIN), and elevated DNA sequence mutational diversity. TRACERx has revealed that elevated DNA copy-number ITH rather than DNA sequence diversity is associated with increased risk of recurrence or death in non-small cell lung cancer (NSCLC). Why macroevolutionary CIN rather than somatic mutational diversity is associated with poor outcome remains unclear. Current animal models of NSCLC do not sufficiently model the multiple distinct patterns of GIN operating in patients. We aim to develop mouse lung cancer models that recapitulate the patterns of GIN observed in NSCLC patients. Using tumour barcode sequencing, a sensitive method of quantifying cellular fitness and individual tumour growth, we will investigate the effects of targeted-, chemo- and immuno-therapy on the newly generated GIN models. We will decipher if distinct patterns of GIN increase metastatic potential and treatment failure, and test if high mutational burden or high CIN increases the frequency of GD in cancer. Finally, we aim to investigate the effects of GIN upon immune surveillance, immune evasion, immunotherapy response, and the interactions between tumours and the tumour microenvironment.

Keywords: tumour evolution,genomic instability,chromosomal instability,genome doubling,mutation,immune escape,nsclc,lung cancer
Nanomaterial FAte and Speciation in the Environment (NanoFASE)

Framework: Horizon 2020 — Industrial Leadership
Programme: Nanotechnologies, Advanced Materials, Advanced Manufacturing and Processing, and Biotechnology
Theme: Ensuring the safe and sustainable development and application of nanotechnologies
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Spain,Germany,Germany,Germany,Switzerland,Switzerland,Slovenia,Sweden,Sweden,Sweden,Switzerland,Bulgaria,Poland,France,France,Czechia,Czechia,Netherlands,Netherlands,Netherlands,Netherlands,United Kingdom,United Kingdom,United Kingdom,Portugal,United Kingdom,United Kingdom,United Kingdom,United Kingdom
Call: Assessment of environmental fate of nanomaterials (H2020-NMP-2014-two-stage, 2014)
Start date: 2015-09-01
End date: 2019-09-30
Duration (months): 49.0
Total project cost (EUR): 11321076.25
EU funding (EUR): 9954475.5
Participants: 38
Project status: CLOSED

Concept: NanoFASE will deliver an integrated Exposure Assessment Framework, including methods, parameter values, model and guidance that will allow Industry to assess the full diversity of industrial nano-enabled products to a standard acceptable in regulatory registrations. Methods to assess how use phases, waste streams and environmental compartments (air, soil, water biota) act as “reactors” in modifying and transporting ENMs will be developed and used to derive parameter values. Our nanospecific models will be integrated with the existing multi-media fate model SimpleBox4Nano for use in EUSES and also develop into a flexible multi-media model for risk assessment at different scales and complexities. Information on release form, transformation and transport processes for product relevant ENMs will allow grouping into Functional Fate Groups according to their “most probable” fate pathways as a contribution to safe-by-design based on fate. Methodology: Inventories of material release forms along the product value chain are established. We then study how released ENMs transform from initial reactive states to modified forms with lower energy states in which nanospecific properties may be lost. Transport studies assess material fluxes within/between compartments. The experimental work underpins models describing ENM transformation and transport. Open access is provided to the models suitable for incorporation into existing exposure assessment tools (e.g. SimpleBox4Nano) and for more detailed assessment. Framework completeness is validated by case studies. Impact: Identified links between ENM material properties and fate outcome (e.g. safe-by-design). Improved representation of nanospecific processes in existing key fate and exposure assessment tools (e.g. SimpleBox4Nano in EUSES). Contribution to standardization. GIS framework to support predictive assessment, catchment and point source management of ENM releases.

Keywords: industry nm product value chains,release and environmentally relevant nm forms,transformation and transport processes,integrated predictive multimedia environmental nm fate models
Multi-channel time-to-digital converter sensor with ultra high resolution (MCTDC)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Action type: SME instrument
Countries involved: Hungary
Call: Open Disruptive Innovation Scheme (implemented through the SME instrument) (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

In measurements, time-to-digital converter has a fundamental importance with numerous applications. The TDC (Time-to-Digital Converter) executes an analogue-digital transformation. The input analogue value is the time delay between two signals. Whereas the output is a discreet range value, which equals the quantization of the input value. The unity of conversion or the resolution of TDC is the shortest time that changes the output value. At present, the value of this time is in picoseconds range. The aim of this project is to create a TDC which is FPGA (field-programmable gate array) based, made of common electronic parts having many channels. Our goal is the implementation of a special complex electronic circuit whose time resolution is much better than the one of a digitally controlled FPGA. The upcoming product will provide a dynamically configured multi-channel time measuring tool, which overcomes the limitations of the prior art solutions. Its device can be produced cost efficiently, it is not sensitive to quality change and configuration stemming from mass production, and by which the absolute timing of a signal associated with an event can be measured with a high accuracy of 20 ps. MedioTrade Ltd. has already executed significant part of the innovation. We possess a functioning breadboard, which obtained promising results, moreover, both national and international patents were accepted. The huge need and interest from the research centres and companies guarantees a flourishing partnership and significant market share for us. We expecting the rise of research activities and increasing competitiveness of Europe in the global sensor industry. In the framework of the project, we will deepen the existing knowledge about our primary market segments, our competitors and their solutions. We will build up our Intellectual Property and marketing strategy, extensively analyse the return on investment and establish the business plan along with the financial projection

Keywords: time to digital converter,fpga,time measuring device,multi channel
Ears, Eyes and Mind: The ‘SENSE-Cog Project’ to improve mental well-being for elderly Europeans with sensory impairment (SENSE-Cog)

Framework: Horizon 2020 — Societal Challenges
Programme: Health, demographic change and wellbeing
Theme: Active ageing and self-management of health
Action type: Research and Innovation actions
Countries involved: Germany,Germany,Germany,Ireland,Cyprus,Norway,Greece,France,France,France,France,Netherlands,United States,United Kingdom,United Kingdom,United Kingdom
Call: Promoting mental wellbeing in the ageing population (H2020-PHC-2015-two-stage, 2015)
Start date: 2016-01-01
End date: 2022-06-30
Duration (months): 78.0
Total project cost (EUR): 6868286.25
EU funding (EUR): 6541591.25
Participants: 26
Project status: CLOSED

Mental, cognitive, vision and hearing health problems in elderly people are amongst the top 10 public health challenges in Europe. They frequently occur co-concurrently and have an additive negative effect on quality of life and mental well-being. To address this negative impact, and promote mental well-being, particularly from a gender and minority community perspective, SENSE-Cog's aim is to: (1) understand the inter-relationship of sensory impairments and cognitive and mental health functioning; (2) identify novel means of screening/detection for diagnostic and therapeutic purposes; and (3) translate this knowledge into clinical applications for the mental well-being of EU citizens. Methods: SENSE-Cog will use a ‘mixed methods’ approach with a trans-EU, UK-led, multidisciplinary collaboration of 7 EU countries with academics, SMEs, city government and ‘patient-public voice’ members. We will deliver linked Work Packages (WPs) reflecting 7 themes: (1) exploration: an epidemiological analysis of 5 large EU longitudinal databases to detect risk profiles for good and poor mental health outcomes; (2) assessment: the adaptation/validation of assessment tools for cognition and sensory impairment for vulnerable populations, including the development of a composite e-screen for sensory, cognitive and mental functioning; (3) intervention: a clinical trial of a newly developed ‘sensory support’ intervention; (4) participation: an EU ‘patient and public voice’ and innovative public engagement network to inform the WPs and communicate findings; (5) valuation: health economic and cost effectiveness analyses; & (6) management, governance/ethics. Impact: SENSE-Cog will promote earlier detection of sensory, cognitive and mental impairments to enable swift interventions, prevent deterioration and limit negative impacts.

Keywords: mental health,elderly,dementia,hearing and vision impairment,quality of life,health checks,cognitive impairment,longitudinal database,dementia screen,hearing rehabilitation
Intelligent Power Supply Regulator (GESINNE PRO)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Spain
Call: Stimulating the innovation potential of SMEs for a low carbon and efficient energy system (H2020-SMEINST-1-2016-2017, 2016)
Start date: 2016-11-01
End date: 2017-02-28
Duration (months): 4.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Power Quality (PQ) is a key issue for the electricity sector and consumers. The power supplied by the utility generally does not have an ideal sinusoidal voltage because it is affected by events on electricity network (faults, harmonics, lightning strikes, etc.) resulting in PQ distortion and consumers indirect costs. Indirect costs associated with poor PQ, or voltage quality to be more precise, although not obvious are significant for industrial and commercial consumers. These costs show up in the form of energy and efficiency loss, unscheduled downtime, equipment aging, production loss, etc. There is a lack of proper technologies in the market to improve PQ at the consumer's side. Current products just focus on a specific PQ disturbance. There is a need to create new all-inclusive systems at the end-user's side. GESINNE PRO is an intelligent power supply regulator system targeted to the industry, commerce, corporate and administration (low voltage facilities with power installed up to 1.600 kVA) aiming to improve the overall quality of the power supplied by the electricity grid in order to reduce energy consumption, protect loads, and prevent shutdowns. GESINNE PRO can achieve reductions on the energy bill between 6% and 17% and an average annual cost reduction associated to voltage dips of around 45.000 € by intelligently improving the PQ. GESINNE PRO will be developed by GESINNE S.L., a Spanish SME company founded in October 2014, which, in spite of its youth, has been able to achieve a significant business success by identifying and covering the need of improving the PQ to consumers. The current GESINNE GSC will be modified and improved in order to create GESINNE PRO. The proposed project will be profitable with an IRR of 24.48 %, a payback period of 6 years. The estimated total market size for the voltage regulation systems will grow from $1.9 billion in 2014 to $2.4 billion in 2019 at a CAGR of 4.7%. GESINNE PRO aims to get 0.3% of the total market in 2024

Keywords: power quality,voltage dips,smart voltage regulation,voltage disturbances