Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Efficient, Safe and Multi-Functional Operation of Solar-Roads (ESMOS)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: Germany
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2019)
Start date: 2019-08-01
End date: 2020-01-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

As one of the most innovative suppliers of highly efficient solar panels SOLMOVE intends to face the future demands of innovative transportation. As major aspect of long-term industries an almost functional, energy efficient and smart road infrastructure will contribute significantly to perform sustainable and safe infrastructure concepts. SOLMOVE’s innovation are solar modules which can be installed on the road like a solar carpet. The glass tiles specially developed for this purpose combine photovoltaic elements, connections and stable, durable glass surface. The solar modules applied are extra-ordinary robust and durable and can be quickly and easily installed and connected with a "plug-in system". The road is converting sunlight into electricity, using already existing roads as energy source. SOLMOVE is the most experienced manufacturer for solar panels for road surfaces worldwide, with several test cases already established. The glass surface morphology guides light in a verifiably optimized way to the underlying solar cells in comparison to plane surfaces. The modules are non-slip, resilient through vehicles, have a self-cleaning and nitrogen oxides absorbing coating and a better noise absorption vs. asphalt. Target customers are owners of land, road and parking spaces as well as municipalities. Solar roads can refinance road construction and create new markets for municipalities, energy providers, private investors and cooperatives in public-private partnership models. SOLMOVE is currently working with 6 partners on 3 continents to put into practice concepts for first pilot plants in Asia, Europe, USA and the Middle East. The feasibility study in Phase 1 will evaluate further international market entry strategies. The proposed project ESMOS will enable SOLMOVE to overcome barriers for realizing functional solar roads by production planning and increasing customer involvement activities.

Keywords: multi functional road surface,solar carpet,disruptive changes in transportation,refinance of road construction,smart road infrastructure
Digital Cancer Diagnosis Platform (DCDP)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: SME instrument
Countries involved: United Kingdom
Call: SME instrument (H2020-SMEInst-2018-2020-1, 2018)
Start date: 2018-12-01
End date: 2019-05-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

Chromition have developed innovative and disruptive digital cancer diagnostic platform. The platform uses Chromition’s innovative Luminspheres™ nanotechnology combined with spatial pattern recognition software to diagnose cancer. Luminspheres™ are multicoloured fluorescent nanoparticles that are prepared from carbon-based precursors in water at low temperature using our proprietary and environmentally considerate process. Luminspheres™ bioimaging probes when tethered to biological molecules of interest provide sensitive and non-invasive insight into biological processes and interactions with minimal impact on the system under investigation. Chromition are working with the Manchester University NHS Foundation Trust (MFT), using the Luminspheres™-antibody biomarker conjugates to stain tissue samples. The tissue samples are then analysed by Chromition’s digital platform, which is able to analyse multiple biomarkers in a short space of time using bespoke spatial pattern recognition software. Chromition will use Luminspheres™ in Immunohistochemical Staining (IHC) to rapidly identify multiple biomarkers in a single image. The image will then be analysed by innovative software that facilitates fast and autonomous analysis of multiple samples across a clinical cohort. The development of this technology will enable the identification and analysis of multiple biomarkers at a speed not currently possible using existing technology and relying on human sight. The success of this project has the potential to transform the way clinical pathology is practiced. In this project the platform will be used to identify multiple cancer biomarkers in tissue samples from women with endometrial cancers. Utilising the Chromition method firstly for the identification of endometrial cancers, and using the results to tailor medical intervention, will have a significant impact on the cancer burden for women in the EU and globally.

Keywords: cancer diagnosis,precision medicine,biomarker identification
Remembering Activism: The Cultural Memory of Protest in Europe (ReAct)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Advanced grants
Action type: ERC actions
Panel: Cultures and cultural production
Panel description: Literary studies, cultural studies, study of the arts, philosophy
Countries involved: Netherlands
Call: ERC Advanced Grant (ERC-2017-ADG, 2017)
Start date: 2019-01-01
End date: 2024-06-30
Duration (months): 66.0
Total project cost (EUR): 2498750.0
EU funding (EUR): 2498750.0
Participants: 1
Project status: SIGNED

Mass demonstrations are newsworthy. But how are they remembered when they are no longer news? Social movements are usually studied in terms of their emergence and subsidence. Despite recognition that activists are ‘inspired’ by precedents, the afterlife of activism in story and image has never been systematically explored. ReAct contends that knowledge about this cultural memory is needed for a full understanding civil resistance. ReAct will provide the first in-depth account of the remembering and forgetting of activism in Europe since the late 19th century. It will reveal continuities and changes in how protest has been depicted in different media regimes; demonstrate the role of texts, images, and commemorative practices in conveying the memory of protest to later generations; and show how this memory feeds back into later movements at home and abroad. The project is designed around case studies from periods of heightened activism in Europe: 1871-1914; 1960-1970; 2011-2012. Work packages follow 3 intersecting lines of inquiry: mediation (what cultural frames have been used to turn activism into transferable knowledge?); afterlives (how has the memory of particular movements been culturally transmitted?); memoryscapes (how have later movements referenced earlier ones?). A key innovation is network visualization to map the reproduction of narratives and references to predecessors. ReAct will effect a major reorientation in cultural memory research: by developing analytic tools with which to capture the cultural transmission of hope, it provides an alternative to the trauma-based models that currently dominate the field. It will also open up a new area of social movement research by revealing traditions of civic memory and how it is culturally produced. Outside of the academy, ReAct will provide critical literacies with which to rethink collective memory and identity in terms of active citizenship rather than ethnic-national grievances.

Keywords: cultural memory,activism,narrative,transmediality,transnationalism
Pan-European twinning to re-establish world-level Neuroscience Centre in Kiev (NEUROTWIN) (NEUROTWIN)

Framework: Horizon 2020 — Spreading excellence and widening participation
Programme: Widening participation and spreading excellence
Theme: Improved access to Excellence
Action type: Coordination and support actions
Countries involved: Germany,Austria,Ukraine,Sweden,United Kingdom,Portugal
Call: Twinning (H2020-WIDESPREAD-2018-03, 2018)
Start date: 2019-08-01
End date: 2022-07-31
Duration (months): 36.0
Total project cost (EUR): 779562.5
EU funding (EUR): 779562.5
Participants: 6
Project status: SIGNED

The overarching goal of the NEUROTWIN proposal is to re-establish the Bogomoletz Institute of Physiology (BIPH) in Kiev, Ukraine as an international centre for excellence in Cellular and Molecular Neuroscience. This goal is set against a sound background of the existing infrastructure, intellectual traditions and the highly educated manpower. That is the adherence to modern procedures and international research environment which all have to be strengthened to achieve the European dimension and to integrate the Institute into European networks. We shall capitalise on the existing potential of international networking for excellence in Cellular and Molecular Neuroscience research, through knowledge transfer and exchange of best practice between BIPH and leading institutions from the UK, Austria, Portugal, Sweden and Germany. The specific objectives of the proposal target several key areas. They include implementing modern research approaches to scientific excellence and innovation capacity of BIPH via infrastructural changes, large scale knowledge transfer between partners, increasing competitiveness of the BIPH researchers in fundraising from international grant bodies. The quality of the scientific output of BIPH will be improved through continuous training of research staff in academic writing and boosting the quality of post-graduate education. NEUROTWIN will help to boost communication with the policy makers and relevant stakeholders in Ukraine to advocate the importance of neuroscience and neurology research for the improvement of public health and biomedical education. NEUROTWIN will step up and stimulate the scientific excellence and innovation capacity in the field of Cellular and Molecular Neuroscience, as well as strengthening scientific collaboration and international standing of the partners involved.

Keywords: knowledge transfer,neuroscience,education,center of excellence
Asymmetric Organocatalytic Fluorination with fluoride salts (ASYMFLU)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: United Kingdom
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-05-01
End date: 2020-04-30
Duration (months): 24.0
Total project cost (EUR): 183454.8
EU funding (EUR): 183454.8
Participants: 1
Project status: CLOSED

Fluorine is a key element in modern pharmaceutical, agrochemicals and anesthetics. It is well-known that fluorine substitution can strongly improve drug efficiency by modifying the properties of compounds such as lipophilicity, metabolic stability, bioavailability and protein binding affinity. The selective installation of fluorine into molecules, especially in a catalytic way, still represents a major challenge for organic synthesis. To date, chemists have developed a range of transformations for carbon-fluorine bond formation yet the vast majority employs fluorine sources derived from F2, a highly toxic and corrosive gas. Only few processes involve the use of cheaper fluoride salts but often require expensive transition metals and suffer from a limited scope. With this proposal, we envision the development of a novel asymmetric metal-free catalytic reaction for carbon-fluorine bond formation by employing cost effective fluoride salts. The organocatalytic process we have designed is mechanistically unprecedented and will be applied to the synthesis of enantiopure fluoroamines which have a direct application in medicinal chemistry. This novel methodology will therefore provide a novel toolbox of reactions for chemists both from academia and industry and has the potential to have a strong impact on society by improving diagnostics, patient care and health-related quality of life.

Keywords: fluorination,organocatalysis,fluoride metals,fluoride salts,fluoroamines,positron emission tomography,radiolabelling
Cyber Physical Systems for Europe (CPS4EU)

Framework: Horizon 2020 — Industrial Leadership
Programme: Information and Communication Technologies
Theme: Public-private partnerships
Destination: Electronic Components and Systems
Action type: Innovation actions
Partnership: ECSEL (Art-187)
Countries involved: Germany,Germany,Italy,Germany,Germany,Spain,Italy,Italy,Italy,Spain,Germany,Germany,Spain,Spain,Hungary,France,France,France,France,France,France,France,France,France,France,France,France
Call: ECSEL-2018-1-IA (H2020-ECSEL-2018-1-IA-two-stage, 2018)
Start date: 2019-07-01
End date: 2022-09-30
Duration (months): 39.0
Total project cost (EUR): 52458154.46
EU funding (EUR): 12827005.77
Participants: 46
Project status: SIGNED

In recent years, Cyber Physical Systems (CPS) technologies have become a game changer in strategic sectors such as Automotive, Energy and Industry Automation, where Europe is a world leader. In fact, CPS is a key driver for the innovation capacity of European industries, large and small, generating economic growth and supporting meaningful jobs for citizens. CPS4EU aims to arm Europe with extensive value chain across key sectors by: 1. Strengthening CPS Technology providers, mainly European SMEs, to increase their market share and their competitiveness to become world leaders 2. Improve design efficiency and productivity and enable secure certification 3. Enabling the creation of innovative European CPS products that will strengthen the leadership and competitiveness of Europe by both large groups and SMEs 4. Large Dissemination of CPS technologies. To achieve these goals CPS4EU will: 1. Develop 4 key enabling technologies (computing, connectivity, sensing, cooperative systems) 2. Incorporate these CPS modules through pre-integrated architectures and design tools 3. Instantiate these architectures in dedicated use cases from strategic application: automotive, smart grid and industry automation 4. Improve CPS awareness and usage for all industrial sectors CPS4EU gathers major large companies (BMW, VALEO, THALES, TRUMPF, RTE, ABENGOA, LEONARDO, and SCHNEIDER ELECTRIC), a large set of innovative SMEs and world-class research centres (FHG, CEA, DLR, INRIA, KIT, CNRS) to significantly reduce the development time and certification efforts through pan European collaboration, knowledge exchange and access to the strong value chain in strategic markets, CPS4EU builds on a strong foundation in European and national initiatives. It will enable the European industry to lead strategic markets thanks to high level sharing of CPS technologies across sectors all along the value chain.

Keywords: cyber physical systems,system architecture,automated driving,aerospace automation,energy automation,manufacturing automation,value chain
Static Analysis for the VErification of Spreadsheets (SPARKs)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: France
Call: ERC Proof of Concept Grant (ERC-2018-PoC, 2018)
Start date: 2019-01-01
End date: 2020-12-31
Duration (months): 24.0
Total project cost (EUR): 149533.0
EU funding (EUR): 149533.0
Participants: 1
Project status: CLOSED

Spreadsheet applications (such as Microsoft Excel + VBA) are heavily used in a wide range of fields including engineering, finance, management, statistics and health. However, they do not ensure robustness properties, thus spreadsheet errors are hard to avoid, common and potentially very costly. According to estimates, the annual cost of spreadsheet errors is around 7 billion dollars. For instance, in 2013, a series of basic spreadsheet errors at JPMorgan incurred 6 billion dollars trading losses. To avoid such problems, spreadsheet users need better support from rigorous tools, since the development of industrial spreadsheets typically involves multiple tabs, formulas, macros and data read from external sources (e.g., the internet). However, as of today, spreadsheet environment offer almost no verification support, and third party tools do not allow to reason correctly over macros, and future uses of existing formulas. The MemCAD ERC StG project opened the way to novel formal analysis techniques for spreadsheet applications. Indeed, the MemCAD project led to the design of powerful abstraction techniques to reason over complex data-structures such as tables as found in spreadsheets. During this project, we have implemented AiXL, a prototype that was able to analyze large public benchmarks. It uncovered defects that are beyond the scope of other approaches. We propose to leverage these results into a toolbox able to safely verify, optimize and maintain spreadsheets, so as to reduce the likelihood of errors. The envisioned toolbox relies on automatic and conservative semantic static analysis, so that it will report all occurrences of certain classes of errors. It will have an open architecture with plugins, and will easily extend to user specific properties. This works will take place in a partnership with MatrixLEAD, a startup created based on the results of the ERC MemCAD project. MatrixLEAD will provide industrial use-cases and commercialization plans.

Keywords: spreadsheet,software reliability,verification
Eastern Romanian Business Support Network support for innovative SMEs (ERBSN 4 H2020)

Framework: Horizon 2020 — Industrial Leadership
Programme: Innovation in SMEs
Action type: Specific Grant agreement
Countries involved: Romania,Romania,Romania,Romania,Romania,Romania
Call: EEN H2020 SGA3 (H2020-EEN-SGA3-2018, 2018)
Start date: 2019-01-01
End date: 2019-12-31
Duration (months): 12.0
Total project cost (EUR): 63005.0
EU funding (EUR): 63005.0
Participants: 6
Project status: CLOSED

ERBSN 4 H2020 services in Romania RO2 region will ensure the delivery of “Key Account Management” (KAM) support services for the beneficiaries of the SME Instrument, FTI and FET-Open, as well as services designed to enhance innovation management capacities of SMEs and develop project partners capacities for delivering these consulting services.

Keywords: h2020,key account management,innovation management
Unravelling the role of lysine acetylation in the regulation of glycolysis in cancer cells through the development of synthetic biology-based tools (AcetyLys)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Biotechnology and Biosystems Engineering
Panel description: Biotechnology using all organisms, biotechnology for environment and food applications, applied plant and animal sciences, bioengineering and synthetic biology, biomass and biofuels, biohazards
Countries involved: Israel
Call: ERC Starting Grant (ERC-2015-STG, 2015)
Start date: 2016-07-01
End date: 2022-06-30
Duration (months): 72.0
Total project cost (EUR): 1499375.0
EU funding (EUR): 1499375.0
Participants: 1
Project status: CLOSED

Synthetic biology is an emerging discipline that offers powerful tools to control and manipulate fundamental processes in living matter. We propose to develop and apply such tools to modify the genetic code of cultured mammalian cells and bacteria with the aim to study the role of lysine acetylation in the regulation of metabolism and in cancer development. Thousands of lysine acetylation sites were recently discovered on non-histone proteins, suggesting that acetylation is a widespread and evolutionarily conserved post translational modification, similar in scope to phosphorylation and ubiquitination. Specifically, it has been found that most of the enzymes of metabolic processes—including glycolysis—are acetylated, implying that acetylation is key regulator of cellular metabolism in general and in glycolysis in particular. The regulation of metabolic pathways is of particular importance to cancer research, as misregulation of metabolic pathways, especially upregulation of glycolysis, is common to most transformed cells and is now considered a new hallmark of cancer. These data raise an immediate question: what is the role of acetylation in the regulation of glycolysis and in the metabolic reprogramming of cancer cells? While current methods rely on mutational analyses, we will genetically encode the incorporation of acetylated lysine and directly measure the functional role of each acetylation site in cancerous and non-cancerous cell lines. Using this methodology, we will study the structural and functional implications of all the acetylation sites in glycolytic enzymes. We will also decipher the mechanism by which acetylation is regulated by deacetylases and answer a long standing question – how 18 deacetylases recognise their substrates among thousands of acetylated proteins? The developed methodologies can be applied to a wide range of protein families known to be acetylated, thereby making this study relevant to diverse research fields.

Keywords: acetylation,genetic code expansion,glycolysis,metabolism,photo labile protecting groups,organic synthesis,directed evolution,enzyme substrate recognition
Unraveling key genetic innovations behind the emergence of the root-nodule symbiosis (EvoNIN)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Germany
Call: Marie Skłodowska-Curie Individual Fellowships (IF-EF) (H2020-MSCA-IF-2015, 2015)
Start date: 2017-09-01
End date: 2022-03-30
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

Today's world relies on usage of man-made inorganic nitrogen fertilizer. It is estimated, that 48% of the world's population could only be sustained through application of the nitrogen fertilizer. However, use of nitrogen fertilizer has profound multiple negative effects onto environment and human health. Therefore, development of the improved crops, which can use atmospheric nitrogen as a direct source of N and, therefore, do not rely on fertilizer has became the European and Global political priority. Atmospheric N2 is the largest reservoir of nitrogen on Earth, but it is unavailable to most of the land plants. However, a few plant species (mainly legumes) evolved an ability to form symbiosis with nitrogen-fixing bacteria and use atmospheric nitrogen as the primary source of N. The idea of transferring so-called root-nodule symbiosis to non-symbiotic plants has first appeared in the 1970es, when close to nothing was known about the molecular pathways behind nodulation. A significant international research effort over the past decades has resulted in unraveling the key genes involved in root nodule symbiosis in a number of legume model plants. Surprisingly, most of the discovered symbiotic genes were also found in non-symbiotic plants, making it difficult to elucidate key evolutionary innovations responsible for emergence of symbiosis. However, a long-needed detailed comparative study between nitrogen-fixers and non-fixers was not possible until now. The availability of completely sequenced plant genomes of species with nodal positions within and outside the nitrogen-fixing clade gives me the unique opportunity to compare the key symbiotic regulatory network in symbiotic and related non-symbiotic plants and elucidate which genes, regulatory connections or cis-regulatory elements are missing from the non-symbiotic plants. This knowledge will be ultimately exploited for the experimental transfer of nodulation to important non-symbiotic crops.

Keywords: regulatory network evolution,gene duplication,neofunctionalization,transcriptor factor evolution,root nodule symbiosis,development of novel crops