Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
CAbin NOise from Boundary Layer Excitation (CANOBLE)

Framework: Horizon 2020 — Societal Challenges
Programme: Smart, green and integrated transport
Theme: Public-private partnerships
Destination: Clean Sky 2
Action type: Research and Innovation actions
Partnership: CS2 (Art-187)
Countries involved: France,France,France
Call: Validation of aero-vibro-acoustic model on new aerodynamic configurations. (H2020-CS2-CFP02-2015-01, 2015)
Start date: 2016-09-01
End date: 2019-08-31
Duration (months): 36.0
Total project cost (EUR): 925101.25
EU funding (EUR): 900000.0
Participants: 4
Project status: CLOSED

CANOBLE aims to develop and validate innovative engineering methods and tools up to TRL5 to study, in design phase, the noise generated inside the cockpit and cabin by the external turbulent boundary layer. A unique experimental and numerical data base will be created for the benefit of the European noise community and the European aeronautic industry. A full scale mock-up of a cockpit including a cabin section will be manufactured, instrumented, and tested in a large aeroacoustics Wind Tunnel. To bypass the TBL measurement limitation, an innovative ultra-thin pressure surface array instrumentation will be developed. The array will allow for an accurate measurement thanks to a high density of pressure sensors and the possibility to analysis the acoustic and the aerodynamic contributions of the excitation using a signal separation strategy. In parallel to the test activities, a complete aero/vibro-acoustic modelling strategy will be implemented including a TBL wall-pressure fluctuations model including adverse pressure gradients with the possibility to account for detailed TBL indicators extracted from steady-state computational fluid dynamics analysis. Finally a virtual prototype will be developed, tuned and compared with the WTT results and extended to flight cruising conditions to deliver recommendations for design purpose to the Topic Manager. CANOBLE will be executed by three organisations and will last 36 months.

Keywords: noise,vibration,fuselage,cockpit,turbulent boundary layer excitation,aeroacoustics,vibroacoustics,acoustic transmission,wt testing,modelling,virtual prototype,pressure surface measurement
Protecting patients with enhanced susceptibility to infections (PRONKJEWAIL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Co-funding of regional, national and international programmes (COFUND)-Doctoral programmes
Action type: Marie Skłodowska-Curie actions
Countries involved: Germany,Australia,Italy,Norway,Greece,Sweden,Romania,France,Netherlands,United States,Netherlands,United Kingdom,Denmark
Call: Marie Skłodowska-Curie Co-funding of regional, national and international programmes (COFUND-DP) (H2020-MSCA-COFUND-2015, 2015)
Start date: 2016-09-01
End date: 2021-08-31
Duration (months): 60.0
Total project cost (EUR): 3348480.0
EU funding (EUR): 1674240.0
Participants: 27
Project status: CLOSED

The Microbes in Health and Disease research programme at the University Medical Center Groningen (UMCG) proposes the Doctoral Training Programme PRONKJEWAIL (‘a real gem’) in the field of hospital care and infection. The specific training objective is ‘protecting patients with enhanced susceptibility to infections’. PRONKJEWAIL will recruit 16 international ESRs, who will be trained in research, transferable skills, and network and capacity building. They will be guided by experienced supervisors from the departments of Medical Microbiology, Internal Medicine, Intensive Care, Clinical Pharmacy and Pharmacology, Rheumatology and Immunology, Surgery, Cell Biology, and Pharmacoepidemiology and Pharmacoeconomics at the UMCG. 26 partner organisations, including 14 private sector partners, are committed to support ESR training via mentoring, courses and secondments. Research training builds on four Pillars: 1) vaccines and primary prevention; 2) personalized detection and infection prevention; 3) iatrogenic influence on the microbiome and 4) personalized therapy/stewardship. Each Pillar integrates fundamental, translational and clinical/epidemiological training projects. The high exposure to fundamental, translational and clinical research in academia and industry will increase the ESRs future problem-solving capabilities. Further, ESRs will learn to value mobility through internships at international partner organizations. By providing an excellent scientific working environment PRONKJEWAIL will directly impact on hospital care and, ultimately, it will contribute to enhanced public health. By providing excellent training, PRONKJEWAIL will develop new talent within the next generation of medical researchers thereby strengthening the European Research Area.

Keywords: susceptibility to infections,microbiome,vaccines,personalized detection,personalized treatment,antimicrobial resistance
mARs: Mobile DNA driven antibiotic resistance spreading: molecular strategies, control and evolution for broad distribution (mARs)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Molecules of Life: Biological Mechanisms, Structures and Functions
Panel description: Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modelling
Countries involved: Germany,Switzerland
Call: ERC Consolidator Grant (ERC-2019-COG, 2019)
Start date: 2021-07-01
End date: 2026-06-30
Duration (months): 60.0
Total project cost (EUR): 1999118.0
EU funding (EUR): 1999118.0
Participants: 2
Project status: SIGNED

Antibiotic resistance (AR) is spreading rapidly, leading to the development of highly virulent pathogens and multidrug-resistant ‘superbugs’, a major health concern of our era. Mobile DNA elements, transposons and integrons, effectively drive the spread of AR genes in microbial interaction hotspots, such as bacterial communities in humans and natural environments. Yet, our knowledge of their mechanisms remains very sparse. It is unclear how DNA movement occurs on the molecular level and how it is controlled in cells and communities; biochemical and structural data are rare and our view on their diversity and evolution is limited. Here I propose an integrated approach combining bioinformatics, genetics, microbiology, biochemistry, and structural biology to elucidate the mechanisms and diversity of mobile DNA driven resistance spreading. I want to (a) investigate the molecular mechanisms and regulation of AR gene movement in vitro, in model bacteria and in gut bacterial communities; (b) dissect the structure of the underlying molecular machineries to reveal how protein-DNA interplay promotes gene transfer; and (c) characterize the diversity, evolution and functional success of distinct molecular pathways. Mechanistic work will focus on selected mobile elements that confer resistance to last resort drugs and promiscuous gene carriers with high prevalence in health care. Bioinformatic quests will draw on recent (meta)genomic data to chart the clinical significance of molecular insights in situ. By bridging disciplines, I want to provide functionally annotated molecular movies of gene movement and explain how specific molecular strategies evolved to enable broad dissemination of resistance determinants. The insights gained in this research will provide in-depth knowledge on major AR transfer pathways and will have key implications for the development of novel intervention strategies and preventive measures aimed at reducing dissemination of drug resistance in bacteria.

Keywords: mobile genetic elements,multi drug resistant bacteria,antibiotic resistance transmission,gene transfer,molecular mechanism,microbiome
Plant Particle based Hybrid Bicontinuous Oleogels (PlantOleogels)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Society and Enterprise panel
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Netherlands
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-11-01
End date: 2020-10-31
Duration (months): 24.0
Total project cost (EUR): 165598.8
EU funding (EUR): 165598.8
Participants: 1
Project status: CLOSED

Cardiovascular diseases (CVDs) continue to be the major cause of death in the EU, it accounts for over 1.8 million deaths and estimated economic burden of €210 billion a year to EU. One main dietary risk factor long associated with CVDs is the consumption of hardstock fats. Substitution of saturated fats by unsaturated fats is not always possible since it brings major technological challenges such as products that leak oil and have overall poor quality. To overcome this, a promising strategy is to promote oil gelation to form a type of soft condensed matter termed ‘oleogel’. Despite major breakthroughs in this field, there is a strong need for: creating oleogels derived from all-natural and economical biomaterials that display excellent rheology, shear stability and temperature-responsiveness, while meeting increasing consumer expectations for “clean” and natural labels and establishing structure-rheology relationships in such systems. This proposal aims to create novel hybrid oleogels using plant derived native cellulose- and starch- colloidal particles via two main soft matter approaches: colloidal glass-gel networks and bicontinuous gel with interpenetrated particle networks. Colloidal classes and gels are two types of colloidal systems, with differing structure and that display solid-like characteristics which we seek to exploit under these schemes. To incorporate temperature responsiveness, we will prepare oil continuous colloidal gel and glass in coexistence with fat crystal network. Such hybrid systems will be prepared by simultaneous addition of plant particles at high volume fraction and fat particles at low volume fraction (plant particles entrapped within the fat network), and gel-gel networks will be made by separate aggregation, first of the plant particles and then of fat particles. Structure, rheology, physical properties and phase behaviour will be investigated to identify formulations and soft matter systems with potential for food oil structuring.

Keywords: colloids,colloidal gel,colloidal glass,oleogel,oil gel,lipid gels,bicontinuous gels,hybrid gels,structure,rheology,linear,nonlinear,viscoelasticity
Wave Energy Transition to Future by Evolution of Engineering and Technology (WETFEET)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Theme: New knowledge and technologies
Action type: Research and Innovation actions
Countries involved: Austria,Italy,Italy,Italy,France,Netherlands,Netherlands,United Kingdom,United Kingdom,Portugal,United Kingdom
Call: New knowledge and technologies (H2020-LCE-2014-1, 2014)
Start date: 2015-05-01
End date: 2018-04-30
Duration (months): 36.0
Total project cost (EUR): 3456883.75
EU funding (EUR): 3456883.25
Participants: 14
Project status: CLOSED

The recent experience with ocean wave energy have revealed issues with reliability of technical components, survivability, high development costs and risks, long time to market, as well as industrial scalability of proposed and tested technologies. However the potential of wave energy is vast, and also positive conclusions have been drawn, in particular that wave energy is generally technically feasible. Having substantial insight into successes and drawbacks in past developments and existing concepts, the promoters have identified ‘breakthrough features’ that address the above mentioned obstacles, i.e. components, systems and processes, as well as the respective IP. These breakthroughs are applied to two wave concepts, the OWC and the Symphony, under development by members of the consortium. The following main avenues have been identified: 1. Survivability breakthrough via device submergence under storm conditions; 2. O&M (operation and maintenance) breakthrough via continuous submergence and adaption of components and strategies; 3. PTO breakthrough via dielectric membrane alternatives to the “classical” electro-mechanical power take-off equipment; 4. Array breakthrough via sharing of mooring and electrical connections between nearby devices, as well as integral approach to device interaction and compact aggregates; WETFEET addressees Low-carbon Energies specific challenges by targeting a set of breakthroughs for wave energy technology, an infant clean energy technology with vast potential. The breakthrough features of WETFEET are developed and tested on the platform of two specific converter types (OWC and Symphony) with near-term commercial interest, and a large part of the results can make a general contribution to the sector, being implemented in other technologies.

Keywords: wave energy,breakthrough concepts and components,dielectric membrane,water turbine,reliability improvement,structural survivability,economic competitiveness
Organic-Inorganic Hybrid Heterojunctions in Extremely Thin Absorber Solar Cells Based on Arrays of Parallel Cylindrical Nanochannels (HYBRICYL)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Chemistry
Countries involved: Germany
Call: Individual Fellowships (H2020-MSCA-IF-2017, 2017)
Start date: 2018-07-01
End date: 2020-06-30
Duration (months): 24.0
Total project cost (EUR): 159460.8
EU funding (EUR): 159460.8
Participants: 1
Project status: CLOSED

HYBRICYL project presents novel preparative methods developed towards the fabrication of organic-inorganic heterojunctions in coaxial geometry using arrays of parallel cylindrical nanochannels. The aim of this project is to provide new experimental insight into the function of photovoltaic (PV) systems and optimize the geometrical parameters to improve their efficiency. The goal structures will be achieved based on three different elements: a) nanoporous anodic aluminum oxide (AAO) films, b) atomic layer deposition (ALD) of inorganic semiconductors, and c) the use of organic semiconductors as hole transporter materials and bulk heterojunctions. Nanoporous AAO will be used as template due to the great geometrical flexibility achievable, diameter = 20 - 400 nm; interpore distance = 50- 500 nm; length = 0.1 - 10 um, in self-ordered domains of nanopores. The ALD will be used to coat homogeneously the nanochannels of the AAO with electron conductor materials (TiO2) and light absorber (Sb2S3). The thickness of these layers will be ranging from 5 to 50 nm. Finally, organic hole transporter materials and bulk heterojunction will be infiltrated into the nanochannels in contact with the light absorber to form coaxial organic-inorganic heterojunctions in arrays hexagonally ordered nanochannels. The optical and electrical properties of these PV structures will be studied for a better understanding of the physical process involved. In particular, a series of organic semiconductors will be systematically investigated. This will allow us to optimize the geometrical parameters in function of the charge carriers transport distances (hole mobility) and quantity of light absorbed (absorption coefficient). We will identify the limiting factors of the solar cell efficiency. We will be able to fabricate devices with tailor made geometries to improve the charge generation and collection, and reduce the recombination processes at the interfaces, thereby improving their efficiencies.

Keywords: photovoltaic,extremely thin absorber,polymeric semiconductors,hybrid heterojunction,solar energy conversion
An ultra compact greenhouse gas remote sensing system for ranges between 500 and 2000 m (CarbSens)

Framework: Horizon 2020 — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Proof of concept grants
Action type: ERC actions
Countries involved: United Kingdom
Call: ERC-Proof of Concept-2016 (ERC-2016-PoC, 2016)
Start date: 2017-01-01
End date: 2018-06-30
Duration (months): 18.0
Total project cost (EUR): 149817.0
EU funding (EUR): 149817.0
Participants: 1
Project status: CLOSED

The CO2Volc project (ERC n.279802) has produced an active remote sensing instrument based on the differential absorption LIDAR principle, called CO2DIAL. It is designed to measure column averaged CO2 concentrations for path lengths between 500 and 2000 m. A key advantage over other open-path techniques is that no retroreflector or separate active source is required for fence-line monitoring. It therefore fills a key operational gap in CO2 sensing technologies. In addition, through a laser replacement, the instrument can be used to measure also CH4, allowing both main carbon gas species to be quantified, and producing the name of this project, CarbSens. An affordable greenhouse gas (GHG) sensing platform with spatial coverage of 2000 m that fits into a backpack, can be mounted on an aircraft, car, mast or even a drone would have a wide variety of commercially attractive applications. These include efficient monitoring of CO2 leakage from CO2 storage sites or urban traffic, quantification of fugitive CH4 upon hydraulic fracturing (fracking), CH4 leakage from pipelines or biogas tanks, or refining regional GHG budgets for improved climate modeling. A system with the features of the CO2DIAL is not commercially available. We believe that our technology has the potential to create a new market for affordable, man-portable remote gas sensors, and carbon quantification services. In the initial project phase we will define an adequate commercialization strategy, focusing on user groups in the hydrocarbon and carbon sequestration industries. A commercial prototype will then be derived from the CO2DIAL. A focus will be to make the system affordable (<40 k€) and even more compact and lightweight (< 10 kg) to arrive at an instrument that is suitable for a large group of users. The final goal of the proposal is to produce a portfolio consisting of a working commercial prototype and a marketing strategy, including either secured licensing or the initiation of a spin-out company.

Keywords: carbon,remote sensing,compact,light weight,portable,greenhouse gas,monitoring,fence line monitoring,volcanic co2,carbon quantification services
Bertha G - better enzymes - than gas (BERTHA-G)

Framework: Horizon 2020 — Societal Challenges
Programme: Secure, clean and efficient energy
Action type: SME instrument
Countries involved: Germany
Call: Stimulating the innovation potential of SMEs for a low carbon energy system (H2020-SMEINST-1-2014, 2014)
Start date: 2015-05-01
End date: 2015-10-31
Duration (months): 6.0
Total project cost (EUR): 71429.0
EU funding (EUR): 50000.0
Participants: 1
Project status: CLOSED

BERTHA-G stands for “Better enzymes than gas”. Our first-of-its-class system enables independence from centralized supply of fossil fuel (i.e. natural gas, oil) for residential heating purposes (15’000 kWh therm. p.a). Applied at a national level, our approach can help disrupt the conventional energy supply and shift the demand from limited oil / natural gas from external suppliers to synthetic fuels which are cost-efficient and non-volatile (price), not limited by nature and CO2 neutral.This will be achieved by a cutting-edge proprietary technology: using the platform technology of Gensoric GmbH, an electro-biocatalytical process converts plain water, CO2 from ambient air and electricity into preferably Methanol. In contrast to alternative CO2-to-fuel-technologies, this process runs under mild conditions: no high pressure, no high temperatures. Owing to the selectivity of the enzymatic process, CO2 can be taken from ambient air, there is no need for a refined or concentrated volume streams. All steps can be carried out at ambient conditions which makes it suitable for residential applications. All educts needed are available, even the electrolytic production of hydrogen can be waived, as the enzymes take the needed hydrogen directly from plain water. The electrical energy can be taken from installed renewable energies, an effect which can make installed system more economically viable, especially for storing purposes, which will dramatically increase the efficiency. To facilitate the usage, our system is compatible to already existing infrastructure. Through our solution, we empower the customer to become a “prosumer” or producer and consumer of energy to mitigate the volatility of energy prices, to become energy independent, and contribute to a CO2 neutral economy. In contrast to conventional device sellers, we can enhance the attractiveness of the underlying business model by introducing revolving sales through consumables.

Keywords: enzymes,independence
A Data-drivEn computational mEthod for PersonalizeD healthcare in chronic REspiratory diseases through big-dAta analytics and dynamical Modelling. (DEEPDREAM)

Framework: Horizon 2020 — Excellent Science
Programme: Marie-Sklodowska-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: Individual Fellowships (IF)-Standard European Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Information Science and Engineering
Countries involved: Spain
Call: Individual Fellowships (H2020-MSCA-IF-2018, 2018)
Start date: 2020-03-01
End date: 2022-02-28
Duration (months): 24.0
Total project cost (EUR): 172932.48
EU funding (EUR): 172932.48
Participants: 1
Project status: CLOSED

Prediction is crucial to reduce the risk of cardiovascular complications caused by CRDs, a significant public health issue. Intermittent hypoxia caused by obstructive sleep apnea (OSA) is known to contribute to impaired autonomic cardiac function, but the impact of apneas severity on autonomic cardiac function remains unclear. Prediction is performed by using biomarkers, which can be proposed only if the pathophysiological mechanisms which link the severity of sleep apneas with heart rate variability alterations become clearer. A crucial condition to clarify these mechanisms is a close and continuous interaction between experimental observations and data analysis/modeling. This project, which combined advanced computational modeling and signal processing and interpretation techniques to assess the activation of the neural mechanisms related to intermittent hypoxia, offers a concrete possibility to go one step further in the prevention of cardiovascular diseases in OSA.

Keywords: obstructive sleep apneas,biomedical signal interpretation,data driven modeling