Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
PRESCRIPTION OPTICS PROVIDING A UNIVERSAL LENS FOR AUGMENTED REALITY EYEWEAR (POPULAR)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Digital, Industry and Space
Theme: Digital
Destination: A human-centred and ethical development of digital and industrial technologies
Action type: Research and Innovation actions
Countries involved: France,Spain,Germany,Poland
Call: Next Generation eXtended Reality (RIA) (HORIZON-CL4-2023-HUMAN-01-CNECT, 2023)
Start date: 2024-01-01
End date: 2026-12-31
Duration (months): 36.0
Total project cost (EUR): 6732178.75
EU funding (EUR): 6732178.75
Participants: 11
Project status: SIGNED

POPULAR aims at developing the first generic Augmented Reality Eyewear (ARE) platform covering the widest range of users and use cases, in professional context, leisure, or in daily life. The ordinary-looking glasses will provide visual, wearable, vestibular, and social comfort, making them suitable for all-day use, including personal ophthalmic correction. Major innovations are related to compactness and invisible technology, optical quality, ultra-low power consumption and long operation times, integrating cost-efficiency aspects as well. SSH aspects will be considered in all stages of the project by using a dual approach with an interplay between Human Driven Design and multidisciplinary system engineering through iterative prototype testing. POPULAR will develop all critical components, namely ultra-low power microdisplay with related optics and electronics, innovative Holographic Lens Mirror, as well as application software, and perform the integration into eyewear prototypes. Demonstration will be achieved by performing end-user tests with the prototypes in 3 realistic use case scenarios: outdoor sports, healthcare, and logistics. The consortium is a unique combination of cross-functional experts, representing the entire value chain. It consists of 10 partners from 4 EU countries, including 4 RTO/ACA, 3 industrial companies of which 2 SMEs, and 3 use-case partners. In addition, an Advisory Board of stakeholders and ethics experts will guide the POPULAR consortium during the main steps of the project. The innovation provided by the project provides a unique chance to the European industry becoming a leader in a growing market of ARE, building on its worldwide leadership in the Eyewear industry and its strong R&D and Innovation capabilities. Through the project demonstrations and the continuous support of the Advisory Board, guidelines covering user, design, market and societal requirements will be developed, supporting deployment in real scenarios.

Keywords: augmented reality,wearable technology,ophthalmic prescription,holographic optical element,oled,microdisplay,human driven design
Electric bReaker Hammer transforming the mIning aNd cOnstruction industries to zero-emission. (RHINO)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Finland
Call: Green Deal innovations for the Economic Recovery (HORIZON-EIC-2021-ACCELERATORCHALLENGES-01, 2021)
Start date: 2022-07-01
End date: 2024-06-30
Duration (months): 24.0
Total project cost (EUR): 2414250.0
EU funding (EUR): 1666350.0
Participants: 1
Project status: CLOSED

A fully electrical impact hammer (LEH) is proposed in this project in order to address the fundamental limitations from hydraulic breaker hammers (HBHs), as well as fostering opportunities in regard to electric transformation, digitalization (DigiLeka) and data based business in the construction and mining industries. This novel patented technological innovation is based on the tubularic linear permanent magnet motor. Compared to HBHs, LEH reduces CO2 emissions up to 100%, saves energy up to 60%, ends oil spills and excessive consumption of hydraulic oil, is fully adjustable, increases safety, lowers noise and tremor levels, provides significant life-cycle-cost savings (80000 EUR/hammer in 4 years), increases performance and precision, and allows adjusting striking sequence. This project will result in a totally new approach to hammering process in mining and construction providing a ground-breaking cost efficient, digitalized, connected, safe, environmental and user friendly solution.

Keywords: sustainable mining,electric breaker hammer,construction,zero emission
Supply Chain & Automated production Line Expansion for AEM electrolysers (SCALE-AEM)

Framework: Horizon Europe — Global Challenges and European Industrial Competitiveness
Programme: Climate, Energy and Mobility
Theme: Public-private partnerships
Destination: Clean Hydrogen
Action type: Research and Innovation actions
Partnership: CLEANH2 (JU-JTI)
Countries involved: Germany,Israel,Italy,Spain,Belgium
Call: Scale-up and Optimisation of manufacturing processes for electrolyser materials, cells, or stacks (HORIZON-JU-CLEANH2-2025, 2025)
Start date: 2026-01-01
End date: 2028-12-31
Duration (months): 36.0
Total project cost (EUR): 5255199.03
EU funding (EUR): 3999439.1
Participants: 7
Project status: SIGNED

Anion exchange membrane electrolysis (AEMEL) is the most promising technology for affordable, clean hydrogen production in Europe. It avoids use of costly or harmful materials and benefits from dynamic pricing of renewable energy. However, production scale-up is currently hampered by short technical lifespan and lack of manufacturing standardisation and automation. SCALE-AEM aims to resolve these bottlenecks and will: 1. Increase production rates, while reducing production costs by scaling up and automating production processes throughout the supply chain, from raw materials to stack production, while reducing waste and rejection of parts or stacks due to anomalies 2. Enhance performance and operational lifetime, by developing a next generation AEMEL stack, with improved membrane and catalyst lifetime 3. Improve life cycle of the stack and its components with more circularity and sustainability, through integrated life cycle management in development, design, and (dis)assembly SCALE-AEM unites the entire manufacturing supply and production chain for AEMEL electrolysers. It includes 4 innovation-driven SME’s’; BRAM (flow plate/bipolar plate), HYD (membrane), MAT (cathode/anode electrodes) and V2H (system integration and performance optimisation), and large company COMAU (automation and process engineering), guided by leading European institute FRA and supported by network organisation ERIG. SCALE-AEM will validate a production line capable of producing up to 100kW AEMEL stacks at €300 (kg/d) level, translating into clean hydrogen produced at less than ~3.00 €(kg/d), below the costs of Steam Methane Reforming for grey hydrogen. The long-term ambition of the consortium is to obtain investments for a 1GW production line per year, operational by 2030, fulfilling 10% of EU’s need by 2035. By replacing fossil hydrogen to continue AEMEL technology developments, and driving further cost reductions, the EU can be a global leader in electrolyser production.

Keywords: aem electrolyser,manufacturing,assembly,sustainability
MAGHEAT: understanding energy deposition in the solar chromosphere (MAGHEAT)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Consolidator grants
Action type: ERC actions
Panel: Universe Sciences
Panel description: Astro -physics/ -chemistry/ -biology; solar system; planetary systems; stellar, galactic and extragalactic astronomy; cosmology; space sciences; astronomical instrumentation and data
Countries involved: Sweden
Call: ERC CONSOLIDATOR GRANTS (ERC-2022-COG, 2022)
Start date: 2023-07-01
End date: 2028-06-30
Duration (months): 60.0
Total project cost (EUR): 1994937.5
EU funding (EUR): 1994937.5
Participants: 1
Project status: SIGNED

The mechanisms that heat the solar chromosphere and corona, and that drive the solar dynamo, arguably remain some of the foremost questions in solar and stellar physics. Here, we focus on the question of how energy is transported and released in the solar chromosphere. During the past 20 years, numerical simulations of the chromosphere have been used, with increasing degree of sophistication, to validate various proposed heating mechanisms. These studies have gradually come to recognise that the mechanisms that are likely dominant may be different in different parts of chromospheric fine structures. To make progress, we therefore need constraints from highly resolved observational data. Recently, I implemented an inversion code that allows estimates of the overall chromospheric heating from spatially and spectrally resolved observational maps. Our results have unveiled very finely structured heating distributions with much larger amplitudes than the hitherto assumed canonical values. But a limitation is that this implementation cannot directly discriminate between the different heating mechanisms that have been proposed. The goal of MAGHEAT is to identify what mechanisms are heating the chromosphere, characterize the energy flux that is being released into the chromosphere and separate the contribution from each mechanism in active regions and flares. This goal is achievable with the combination of the proposed development of novel non-LTE inversion methods, new hybrid rMHD/particle simulations, and the availability of datasets with unprecedented high spatial resolution, large field-of-view, and high S/N ratio from DKIST, the Sunrise III mission, NASA’s IRIS satellite and updated instrumentation at the Swedish 1-m Solar Telescope. We will use observational data from these facilities to reconstruct new 3D empirical models of the photosphere and chromosphere, which will allow us to identify the mechanisms that are responsible for the energy deposition.

Keywords: nlte radiative transfer,chromospheres,nlte inversion methods
Bringing Lithium-Ion Battery Waste tozero (ToZero)

Framework: Horizon Europe — Innovative Europe
Programme: The European Innovation Council (EIC)
Theme: EIC Accelerator
Destination: Challenges
Action type: EIC actions
Countries involved: Germany
Call: Renewable energy sources and their whole value chain including materials development and recycling of components (HORIZON-EIC-2024-ACCELERATOR-02, 2024)
Start date: 2024-12-01
End date: 2026-11-30
Duration (months): 24.0
Total project cost (EUR): 3571360.0
EU funding (EUR): 2499952.0
Participants: 1
Project status: SIGNED

tozero is committed to its mission to truly bring lithium-ion battery waste to zero. With its novel hydrometallurgical (i.e. wet chemical) battery recycling approach, it can maximize the recovery of critical raw materials (lithium, nickel, cobalt, manganese, and graphite) from both lithium-ion batteries that have reached their end of life, and scrap created during the production of new batteries. Proven on a daily basis in an operational pilot plant (commissioned in July 2023) close to Munich, Germany, tozero already now fulfills the recovery rates for critical raw materials from lithium-ion battery waste required by the recently enforced EU Battery Directive for 2027 and 2031 and established itself as one of the leading battery recycling startups in Europe. In addition, the use of less aggressive chemicals than competitors and a mostly closed circular production process reduces the carbon footprint for batteries using tozero’s recycled material compared to batteries using mined materials by up to 80%. Considering an initial pre-seed funding of EUR 3.5mn in 2022, receiving the EIC grant would allow to significantly accelerate tozero´s scale up to industry-scale commercialization and bridge the gap for the next funding round. First, this includes additional funds from the EIC for the purchasing and in-house optimization of chemical reactors tailored to the innovative hydrometallurgical process of tozero. Second, it allows us to largely automate our processing and prepare for industry-scale processing. Third, it supports in the creation of a full lifecycle assessment that is required to officially accredit our CO2e savings and helps to identify the largest lever to further reduce our environmental footprint. All three aspects combined allow to reach an industrial scale proof of our operations and unlock a large equity financing round in 2026.

Keywords: battery recycling,critical raw material provision,circular economy,lithium ion battery recycling,e mobility
ECONOMIC, LEGAL AND IP FEASIBILITY STUDIES OF EXHEUS VITAL TEST (EXHEUSVITAL)

Framework: Horizon Europe — Innovative Europe
Programme: European innovation ecosystems
Theme: Elevating the scalability potential of European business
Destination: Elevating the scalability potential of European business
Action type: Coordination and support actions
Countries involved: Spain
Call: Women TechEU (HORIZON-EIE-2022-SCALEUP-02, 2022)
Start date: 2023-07-01
End date: 2023-12-31
Duration (months): 6.0
Total project cost (EUR): 107142.86
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

Exheus VITAL is a unique, evidence-based innovative solution that supports HCPs in providing personalized treatment plans and recommendations to people suffering from obesity to effectively achieve weight management goals. The proprietary technology is based on individual’s gene activation analysis that is converted into insightful health intelligence reports which provide information on the health status of the individual, allow monitoring of patients’ over-time and a prognosis of possible pathologies. Exheus leads to unparalleled health outcomes, benefiting the individual and the society by driving cost-effectiveness of therapy. Exheus VITAL offers advantages such as: 1.The information provided together by the RNA sequencing and by the Exheus AI technology allows to obtain precise information of the abnormalities in gene expression for each patient. This allow a high level of personalization that can’t be achieved with other methods to provide the best treatment for a given patient. 2.It allows to increase the adherence to the weight loss treatment increasing the effectiveness of the recommendations. 3.It helps HCPs motivate the patient and improve willingness to follow the health recommendations, therefore promoting a change in lifestyle habits sustainable over the time. 4.HCPs (i.e endocrinologist, primary care physicians) can now treat obesity through a clinically validated personalized medicine tool to guide and accompany the patient during its healthy weight loss process. 5.Monitoring the evolution of activated genes over time can be done through repeated tests to determine changes in these parameters. Exheus VITAL is a fast, effective and attractive tool that helps Health Care Professionals (HCPs) to efficiently support patients with obesity in their weight loss goals. It has been demonstrated that the delivery of the scientifically proven insights (expression levels and changes) and recommendations using a digital method will be effective.

Keywords: obesity,healthspan,lifestyle,rna,ai
Understanding temporal shifts in mosquito host-seeking as drivers of behavioral resistance to insecticide-treated bed nets. (MosqBedTiming)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Environment and Geosciences
Countries involved: Netherlands
Call: MSCA Postdoctoral Fellowships 2024 (HORIZON-MSCA-2024-PF-01, 2024)
Start date: 2026-03-01
End date: 2028-02-29
Duration (months): 24.0
Total project cost (EUR): 217076.16
EU funding (EUR): 217076.16
Participants: 1
Project status: SIGNED

Mosquitoes transmit malaria parasites by feeding on humans, claiming approximately half a million lives each year. Insecticide-treated nets (ITNs) have been an effective method to reduce malaria mortality by protecting people from mosquito bites at night. However, mosquitoes are now changing their host-seeking behavior, biting before nightfall reducing ITN effectiveness. This project aims to understand the origins of these behavioral shifts using innovative methodologies. Two mechanisms are hypothesized to drive this shift: genetic evolution or phenotypic plasticity. ITNs may select for mosquitoes genetically hardwired to bite early, or mosquitoes might adapt behaviorally without genetic changes. These mechanisms have different implications for long-term ITN effectiveness and require different countermeasures. We currently lack the tools to accurately test these hypotheses. I recently developed a behavioral assay to longitudinally monitor mosquito activity in the lab continuously over weeks. I now aim to adapt this method for field deployment to investigate temporal shifts in mosquito behavior in malaria-endemic regions with varying levels of ITN use. I will merge lab and field research through three objectives: (1) Develop an assay to monitor mosquito host-seeking rhythms and environmental variables in the field. (2) Deploy the assay in malaria-endemic areas with varying ITN exposure. (3) Dissect the genetic and environmental factors driving host-seeking shifts in lab experiments. The project combines my experience in biophysics and hardware development with Prof. Teun Bousema's expertise in malaria fieldwork, and Dr. Felix Hol's expertise in mosquito behavior to address the urgent issue of mosquito behavioral resistance to ITNs. This work will help design next-generation vector control strategies by understanding the factors driving behavioral shifts that diminish the effectiveness of ITNs.

Keywords: behavior mosquito host seeking malaria vector control anopheles behavioral resistance
Investigating the regulation of the senescence-associated secretory phenotype (SASP) by mitochondrial DNA (mtDNA) metabolism for the development of novel senotherapies. (MitoDNASen)

Framework: Horizon Europe — Excellent Science
Programme: Marie Skłodowska-Curie Actions (MSCA)
Theme: Marie Skłodowska-Curie
Destination: Postdoctoral Fellowships
Action type: Marie Skłodowska-Curie actions
Panel: Life Sciences
Countries involved: Sweden
Call: MSCA Postdoctoral Fellowships 2023 (HORIZON-MSCA-2023-PF-01, 2023)
Start date: 2024-09-20
End date: 2026-09-19
Duration (months): 24.0
Total project cost (EUR): 206887.68
EU funding (EUR): 206887.68
Participants: 1
Project status: SIGNED

In response to various stresses such as DNA damage, telomere erosion, or oncogene activation, human cells can enter senescence. This process is characterized by irreversible proliferative arrest, deep transcriptional reprogramming, and expression of a collection of inflammatory factors termed the SASP (senescence-associated secretory phenotype). As it limits the proliferation of cells potentially bearing neoplastic potential, the triggering of cellular senescence is an essential tumor suppressing mechanism. However, the persistence and accumulation of senescent cells in aging and pathological contexts can have deleterious effects, particularly due to the SASP. It is thus fundamental to understand the basic physiology of senescent cells to develop so-called senomorphic drugs that modulate SASP expression. Changes in mitochondrial physiology elicited during cellular senescence onset strongly suggest that the maintenance and integrity of their mitochondrial DNA (mtDNA) may be altered. For instance, cytosolic leakage of mtDNA has been shown to take place in senescent cells and participate in SASP expression via immune pathways activation, but the contribution of mtDNA metabolism and replication in SASP expression has not yet been explored. My preliminary results show that mtDNA copy number increases continuously during senescence progression, accompanied by recomposing of the mitochondrial replisome. I also showed that this increase in mtDNA copy number promotes SASP expression. In the present project, I will characterize in details the alterations in mtDNA maintenance and integrity during senescence; profile the evolution of mitochondrial replisome composition; and characterize how the previous regulate SASP expression. The perspective of this project is to identify new senomorphic targets for controlling SASP expression and hereby alleviate the adverse effects of senescent cells in pathological contexts.

Keywords: cellular senescence sasp dna maintenance mitochondrial dna mtdna mtdna deletions mitochondrial replisome stalling bioid
Unraveling novel Archaeal Metabolic Pathways impacting Greenhouse Gas Emissions (ARCHAEBOLIC)

Framework: Horizon Europe — Excellent Science
Programme: European Research Council (ERC)
Theme: European research council
Destination: Starting grants
Action type: ERC actions
Panel: Environmental B iology, Ecology  and E volution
Panel description: For all organisms : Ecology, biodiversity, environmental change , evolutionary biology, behavioural ecology, microbial ecology , marine biology, ecophysiology, theoretical developments and mod elling
Countries involved: Germany
Call: ERC STARTING GRANTS (ERC-2024-STG, 2024)
Start date: 2025-03-01
End date: 2030-02-28
Duration (months): 60.0
Total project cost (EUR): 1485968.0
EU funding (EUR): 1485968.0
Participants: 2
Project status: SIGNED

Archaea are remarkable microorganisms that form next to bacteria and eukaryotes one of the three domains of life and have shaped Earth’s biogeochemistry and climate for billions of years. These microorganisms are the main producers of the greenhouse gas methane. Especially in view of climate change, it is crucial to understand all factors impacting greenhouse gas emissions. Methanogenic archaea are at the center of my research. Recent breakthroughs in this field have been driven by the discovery of many new archaeal lineages via (meta)genomic sequencing. However, physiological characterization and isolation attempts of archaea lag far behind and the evolution of methanogenic archaea is still heavily debated. Now is the right time to investigate the still underexplored metabolic capabilities of (methanogenic) archaea, their impact on greenhouse gas emissions and to enrich novel archaea. I recently discovered a metabolic pathway enabling archaea to produce methane and/or CO2 from wood components and, in silico, from prevalent methylated compounds such as chloromethane. The novel enzyme systems involved are widespread and new metabolic pathways involving a variety of methylated substrates can be predicted, suggesting an important role of archaea in anaerobic conversions of lignin and various methylated compounds to methane and/or CO2. Therefore, I aim to (i) characterize these novel enzyme systems biochemically and in regard to their evolution, (ii) study the physiology of the archaea using these systems and (iii) evaluate the role of these archaea in the environment and for methane and CO2 emissions. This proposal has the potential to revolutionize our view on the metabolic versatility of archaea by unraveling novel mechanisms of methane and CO2 production in a ground-breaking manner. Identifying new archaeal substrates involved in methane and CO2 production enables us to assess the impact of these conversions on the environment and global methane and CO2 budgets.

Keywords: microbial metabolic pathways,methanogenesis,methane and co2 emissions,archaea