Data-Gouv-ML/pcri-informations-sur-les-projets-laureats huggingface dataset:
Determination of the role of P. gingivalis and P. intermedia proteases in mono- and synergistic mixed microbial infections in a mouse model of periodontal disease. (PERIOPAIN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Poland
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2008-10-01
End date: 2012-09-30
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Periodontitis is a chronic inflammatory disease of the supporting structures of the teeth caused by a polymicrobial infection and, despite the general improvement of oral health status and advances in treatment; it continues to afflict a large percentage of adults worldwide. If morbidity caused by tooth loss due to advanced periodontitis was not enough, mounting evidence suggests a causative link between periodontal and cardiovascular diseases. It is now generally accepted that a relatively small consortium of anaerobic Gram-negative bacteria (P. gingivalis, T. denticola and T. forsythia) described as the “red complex” is strongly associated with the pathological changes in the periodontium. Each of these bacteria is well equipped with virulence factors among which, proteolytic enzymes are the best studied. In the case of P. gingivalis, gingipains were shown to significantly contribute to bacterial virulence in vivo. Proteolytic activity produced by P. intermedia may also add to the destructive potential of the red complex consortium since the presence of this bacterium strongly correlates with the presence of P. gingivalis and T. forsythia in the subgingival communities. We hypothesize that different proteases affect host defense system at different non-redundant sites and these concerted multiple assaults should lead to a significantly greater effect than the additive action of individual proteases. Therefore, we postulate that this kind of interaction occurs in the periodontal pocket and may be experimentally verified using specific mice models of periodontal disease using monomicrobial and synergistic mixed microbial infections with a combination of P. gingivalis and P. intermedia wild-type and protease-deficient mutants. Our proposed hypothesis of combined proteolytic periodontopathogen activity may have significant potential importance for the treatment and prevention of periodontal disease in the future.

Keywords: periodontitis,p. gingivalis,p. intermedia,proteolytic enzymes,gingipains.
Improving Life Cycle analysis tools for sustainability assessment in forestry, agriculture and environment technologies (ECOTOOL)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Research Staff Exchange Scheme
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: France
Call:  (FP7-PEOPLE-IRSES-2008, 2008)
Start date: 2009-06-01
End date: 2011-11-30
Duration (months): 30.0
Total project cost (EUR): 23400.0
EU funding (EUR): 23400.0
Participants: 1
Project status: CLOSED

To comply with the Integrated Product Policy (IPP) advocated by the European Union (2003), being able to measuring the environmental impacts of technologies or processes is now compulsory. IPP is largely based on a life-cycle management (LCM) approach in which Life Cycle Analysis (LCA) are the most popular evaluation methodology. But although numerous advances have been carried out, LCA has still not reached the full fame and level of diffusion that should be necessary with regard to IPP objectives, especially in the case of agro-bioprocesses (agriculture and food, forestry, environment industries). Three main objectives will be followed by ECO-TOOL to encourage its diffusion: 1- Carrying out research for making LCA a more relevant and user- friendly tool in the sector of agro-bioprocesses: the bottlenecks of LCA for agro-bioprocesses will be identified; the feasibility of fast measurement devices for acquiring validated data on soil quality assessment will be tested; LCA software packages will be benchmarked; specific LCA analysis will be carried out on second-generation biofuel production; a simplified LCA-tool will be designed; 2- Encouraging in France the emergence of research and higher education on LCA for agro-bioprocesses, 3- Having ECOTOOL partners turned into major actors of the international community on LCA dedicated to agro-bioprocesses.

Keywords: life cycle analysis,agriculture,organic wastes,agricultural products,forest sciences,environmental impact
String-gauge correspondence as a tool for Nature (STONE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Denmark
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2008-09-30
End date: 2011-09-29
Duration (months): 36.0
Total project cost (EUR): 45000.0
EU funding (EUR): 45000.0
Participants: 1
Project status: CLOSED

The background of this project is the relation between gauge theory and string theory, called the AdS/CFT correspondence. The power of the AdS/CFT correspondence relies on the fact that it represents a tool to describe the behavior of gauge theories, including QCD, in the strong coupling regime, a situation which is in general extremely difficult to analyze. Within this context, one of the main ideas in this project is to use the recently found decoupling limits of the AdS/CFT correspondence (found by T. Harmark and M. Orselli). The importance and advantage of using these decoupling limits is that they provide a decoupled sector of the theory in which the dynamics of gauge theory and string theory greatly simplify. Thus the resulting theory is much less complicated than the full theory but it retains the central features of the full theory. Employing this new technique can yield important progress that goes substantially beyond our current understanding of the following subjects: • The confinement/deconfinement transition in gauge theories. • String theory above the Hagedorn temperature. • A quantum description of black holes. To make progress in each of the subjects listed above is a major undertaking and will require a serious effort to complete. For this reason it is important that the research is carried on in an environment with a broad range of interest and expertise in high energy physics such as the Niels Bohr Institute.

Keywords: string theory,ads/cft correspondence
DBS LNB-STB Optical Fibre Transmission Link (OPTOSAT)

Framework: FP7 — Capacities
Programme: Research for the benefit of SMEs
Destination: Research for SMEs
Action type: Research for the benefit of specific groups
Countries involved: United Kingdom,United Kingdom,France,Finland,United Kingdom,Spain,Germany
Call:  (FP7-SME-2008-1, 2008)
Start date: 2010-01-01
End date: 2011-12-31
Duration (months): 24.0
Total project cost (EUR): 1419776.77
EU funding (EUR): 1086120.69
Participants: 8
Project status: CLOSED

There is an approaching crisis in Direct Broadcast by Satellite (DBS). It is evident in the inefficiency and installation problems with coaxial transmission of the ever-increasing number of terrestrial and satellite broadcast channels available to individual homes and Multiple Dwelling Units. The distribution of signals from DBS Low Noise Blocks to Set Top Boxes is currently based on IF signalling on multiple coaxial cables. In the UK, BSKYB alone installs around 10,000 multi-way switched systems p.a. into Multiple Dwelling Units with 100s of coax cable runs in each. Across Europe there are several 100 million individual installed satellite TV systems with each STB requiring connection of 2 or 4 cables. DBS is also threatened by the growing availability of TV over cable and internet links. The aim of this project is to develop a new high-bandwidth optical technology able to transmit multiple, full satellite data bands on a single fibre cable assembly link with essentially unlimited future capacity. Our proposed technology will also enable the full integration of Sat-TV with very high bandwidth home networking in a single solution, providing future proof connectivity and high quality coomunication at reduced costs. OptoSat will exploit and satisfy a European market worth £5Bn over 5 years.

Keywords: diode lasers
Bridging the Gap conference (BTG2008)

Framework: FP7 — Cooperation
Programme: Environment (including Climate Change)
Destination: Environment (including Climate Change)
Action type: Coordination and support actions
Countries involved: Slovenia
Call:  (FP7-Adhoc-2007-13, 2007)
Start date: 2008-04-01
End date: 2008-08-31
Duration (months): 5.0
Total project cost (EUR): 304897.0
EU funding (EUR): 200000.0
Participants: 1
Project status: CLOSED

The Environmental Agency of the Republic of Slovenia is delighted to host the 4th Bridging the Gap conference: Responding to Environmental Change – from Words to Deeds at the occasion of 10th anniversary of Bridging the Gap conferences. Conference will gather participants from policy, research, business and civil society communities. It will look at the past ten years of Bridging the Gap conference progress and will seek to close the gaps in most prioritised and emerging issues in European Union. It will address gaps in policy, research and in capacities of society to respond to emerging issues and uncertainties to be better prepared for the future and to move toward more sustainable development. Well being gaps will be addressed by looking at environment related impacts to human health and at the provision of ecosystem services. Three headline issues will be the common thread through five themes of the conference. The headline issues of the conference: • Need for urgent action • To put environment in the hearth of economic decision making • To improve communication between scientists, policy-makers, politicians, business and civil society Main themes of the conference: 1. Information gathering and sharing 2. Adaptation to climate change 3. Biodiversity and ecosystem services 4. Sustainable consumption and production 5. Energy and the environment Participants will have an opportunity to follow the conference through various ways of interaction: from listening to presentations and round table discussions of the most distinguished experts and high level politicians to participation at the café discussions in freely brainstorming style and five parallel topic sessions where they will be contributing to conclusions of the conference in respective theme.

Keywords: bridging the gap conference need for urgent action economic decision making communication between scientists,policy-makers,politicians and civil society
Connections between algorithmic and geometric properties of groups (LCFRI)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: European Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Switzerland
Call:  (FP7-PEOPLE-ERG-2008, 2008)
Start date: 2008-10-01
End date: 2012-08-31
Duration (months): 47.0
Total project cost (EUR): 58750.0
EU funding (EUR): 58750.0
Participants: 1
Project status: CLOSED

The topic of this project is the study of groups from a variety of perspectives: algorithmic, combinatorial, geometric and algebraic. The common thread of this work will be solving equations in groups, and understanding what kind of role the nature of the solutions obtained plays in determining the properties of the groups. We will solve problems in areas that range from fixed point theory in free groups and the Post Correspondence Problem in free groups, to properties of a large class of relatively hyperbolic groups. The topic we suggest and the specific questions are of interest to both mathematicians in group theory, geometry and logic, and to computer scientists. Thus the work we propose will bring many different communities together, and will employ techniques from diverse fields.

Keywords: free groups,equations,complexity,post correspondence problem,actions on trees,fixed point theory,limit groups,hyperbolic groups,cat(0)
Designing metallopeptides for the removal of superoxide radicals (MFROSPEP)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Portugal
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-04-01
End date: 2013-03-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

Oxidative stress results from an imbalance between the generation of reactive oxygen species and the antioxidant defense mechanisms. In recent years, oxidative stress has been implicated in a variety of detrimental health conditions including cardiovascular diseases, neurodegenerative disorders, and other types of age-related diseases. Evidence shows that the formation of superoxide radicals is a common denominator associated with all these conditions. Considering that cardiovascular diseases are the number one cause of death globally and neurodegenerative diseases are becoming a major health burden due to the aging of the global population, it is not surprising that a great deal of interest has been shown to develop new therapeutic approaches for scavenging these dangerous radicals. Superoxide dismutases (SODs) are endogenous metalloenzymes that catalyze the dismutation of these radicals into the less toxic dioxygen and hydrogen peroxide. Thus, they play a key role in cellular protection against oxidative stress conditions. The present proposal will focus on the design, synthesis and characterization of Mn/Fe SOD peptide mimics. The working hypothesis is that by designing peptides that contain the same metal binding sites as those present in the native SODs there is potential for developing novel structural and functional SOD mimics. To this aim, different native-like protein/peptide scaffolds will be prepared. Mn and Fe binding affinities, redox potentials and SOD activity will be determined for the different constructs with the objective of obtaining crucial structure-activity-redox relationships. The completion of this research will increase our understanding of the structural basis needed for the dismutation of superoxide radicals. As this understanding evolves and is further refined, it should allow us and other research groups to make inroads in designing more effective SOD mimics.

Keywords: metallopeptides,de novo peptides,manganese,iron,reactive oxygen species,superoxide dismutases
Hierarchical Motif Vectors for Protein Alignment and Functional Classification (MOTIF VECTORS)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Türkiye
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2009-11-11
End date: 2012-11-10
Duration (months): 36.0
Total project cost (EUR): 75000.0
EU funding (EUR): 75000.0
Participants: 1
Project status: CLOSED

This proposal introduces hierarchical motif vectors for numerical analysis of sequence motifs, and develops a novel framework for alignment and functional classification of proteins. Hierarchical motif vectors will be computed using multi-scale decompositions of property sequences obtained by converting amino acid sequences into numeric sequences of various amino acid properties. These hierarchical motif vectors will capture the variations of amino acid properties in the vicinity of each amino acid in the sequence of a given protein. We will develop alignment algorithms for amino acid sequences that match their hierarchical motif vectors. We will also use unsupervised statistical learning algorithms to identify hierarchical motif vectors specific to functional protein groups, notably the antigen binding proteins, transcription factors, growth factors, and glycosylation proteins. We will then apply these methods to protein classification, using the overlap scores from the hierarchical motif vector-based sequence alignment as well as the presence and extent of hierarchical motif vectors specific to the protein group in consideration. We will validate all methods developed in this project against existing sequence alignment, motif detection, and protein classification algorithms in the literature. Among the innovations of the project is the use of hierarchical motif vectors for characterization of local physico-chemical variations along an amino acid sequence. This allows analyzing sequence motifs by general machine learning methods via the embedded vector space arrangement. Next, sequence alignment can be tuned to different amino acid properties at various scales, improving the potential for sequence alignment-based protein similarity in functional classification. Furthermore, group-specific hierarchical motif vectors will be identified as those that occur exclusively among the members of a protein group, increasing their likelihood of bearing functional specificity.

Keywords: computational biology,biomedical engineering,protein alignment,protein function prediction,sequence motifs
Theory of Dynamical Processes in Semiconductor Nanostructures (NANODYN)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Germany
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2008-11-01
End date: 2012-10-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

We envision to develop a computational method base on first-principles (i.e., ab-initio) and empirical pseudopotentials that is, unlike any other method, able to treat the relevant size range of semiconductor nanostructres (i.e., between 1000 and one million atoms), on an atomistic footing, including dynamical effects at the many-body level. The method will be developed following a bottom-up approach, i.e., starting from the most accurate description available such as density functional theory. The vibrational and electronic properties obtained this way for small clusters consitute the back-bone of the method and will be used to construct a robust and accurate desciption based on classical force fields (for the phonons) and semiempirical pseudopotenitals (for the electrons). The results obtained, including electron-phonon coupling, will then be used in a configuration interaction approach that will give us access to the correlated many-body wave functions of the excitation. The developments lean on developments undertaken by the P.I. in the last 6 years and will be accurate and general; being able to deal with arbitrary shapes and a wide range of materials. From the resulting many-body wave functions (including phonons) a wide range of new physical effects will be available, such as electronic relaxation times, spin relaxation times, temperature effects, Raman spectra, Polaron couplings, photon linewidth, which are key components in fields such as quantum information/computing, spintronics, lasers, nano-electronic devices, photovoltaic and even medicine. Besides its relevance for nanotechnology, the development presented here will have a significant impact for basic science research. Many of the concepts valid in solid-state physics are challenged in the nanometer scale and many fundamental discoveries can be expected that cross the boundary of physics to chemistry and biology.

Keywords: nanostructures,semiconductors,phonons,electron-phonon coupling,optical properties,density functional theory,empirical pseudopotential
Constraining Dark Energy: an observational study of the properties of dark energy and dark matter (CODE)

Framework: FP7 — People
Programme: Marie-Curie Actions
Theme: Marie Skłodowska-Curie
Destination: International Re-integration Grants
Action type: Support for training and career development of researchers (Marie Curie)
Countries involved: Netherlands
Call:  (FP7-PEOPLE-IRG-2008, 2008)
Start date: 2008-09-01
End date: 2012-08-31
Duration (months): 48.0
Total project cost (EUR): 100000.0
EU funding (EUR): 100000.0
Participants: 1
Project status: CLOSED

The recent discovery that the expansion of the universe is accelerating due to an unknown “dark energy” highlights the limited understanding of the major constituents of the universe. This surprising result, along with the finding that most matter is invisible, sets the stage for research in cosmology at the start of the 21st century: the study of the distribution of “dark matter” and the properties of the dark energy are among the most important problems in astronomy. It is a data-driven endeavour since we lack a clear theoretical framework. The objective of this proposal is to advance observational constraints to a level where physical mechanisms that could underlie the dark energy can be distinguished. The method of choice for this proposal is a relatively new technique called “weak gravitational lensing”, which allows one to “map” the distribution of dark matter and how it evolves with time. It also provides a unique way to study the mass distribution in massive clusters of galaxies. Understanding the formation and physical properties of these rare systems is mandatory, if their number density as a function of mass and redshift is to be used as a cosmological tool. The aim of this proposal is to fully exploit the large amounts of world-class data the applicant has access to. The resulting measurements of the dark energy properties will be among the most accurate ones available, and this work will be an important step forward to reach the ultimate goal of percent level accuracy. In addition, a number of ancillary projects, in particular the study of dark matter halos around galaxies, will provide unique constraints on the properties of dark matter.

Keywords: physical sciences,astronomy,cosmology,dark matter,dark energy